If this is the first time you are viewing this file, please choose 'Save As' from the 'File' menu and resave this file as an Excel file type. This will greatly speed up future viewings of this file.
Chemical Name: | Milk Thistle Extract |
---|---|
CASRN: | ="84604-20-6" |
Study Number: | C20008 |
Study Length (Year Completed): | 13 Weeks (N/A) |
Exposure Route: | FEED |
TDMS Number: | 2000802.fixtime |
Sex: | Female |
Strain and Species: | B6C3F1 Mice |
Hematology Individual Animal Data | |||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Measurement Time | Animal Number | Dose Group (ppm) | Control Code | Erythrcyt (million/uL) | Hgb (g/dL) | HCT (Automated) (%) | HCT (spun) (%) | MCV (fL) | MCH (pg) | MCHC (g/dL) | Retics (million/uL) | Retics (%) | Platelet (1000/mL) | Leukocytes (1000/mL) | Neut (1000/mL) | Lymph (1000/mL) | Mono (1000/mL) | EOS (1000/mL) | Basophils (1000/mL) | NRBC (per 100 WC) | LUC (1000/mL) |
Day 93 | 0061 | 0 | U | 10.74 | 16.7 | 48.6 | 48.0 | 45.2 | 15.5 | 34.3 | .239 | 2.2 | 668 | 5.87 | 0.66 | 4.82 | 0.06 | 0.26 | 0.01 | 0 | 0.05 |
Day 93 | 0062 | 0 | U | 10.58 | 16.0 | 46.6 | 46.3 | 44.0 | 15.2 | 34.5 | .267 | 2.5 | 1191 | 7.78 | 1.43 | 5.99 | 0.10 | 0.19 | 0.03 | 0 | 0.05 |
Day 93 | 0063 | 0 | U | 10.49 | 16.1 | 47.2 | 46.8 | 45.0 | 15.3 | 34.1 | .231 | 2.2 | 849 | 6.04 | 0.65 | 5.07 | 0.06 | 0.22 | 0.02 | 0 | 0.03 |
Day 93 | 0064 | 0 | U | 10.34 | 15.7 | 45.5 | 43.8 | 44.0 | 15.2 | 34.5 | .227 | 2.2 | 1172 | 5.95 | 0.59 | 5.03 | 0.07 | 0.21 | 0.01 | 0 | 0.05 |
Day 93 | 0065 | 0 | U | 10.38 | 16.3 | 46.9 | 45.8 | 45.2 | 15.7 | 34.7 | .228 | 2.2 | 795 | 3.96 | 0.34 | 3.11 | 0.06 | 0.43 | 0.01 | 0 | 0.02 |
Day 93 | 0066 | 0 | U | 10.69 | 16.1 | 48.1 | 47.5 | 45.0 | 15.1 | 33.4 | .213 | 2.0 | 812 | 5.49 | 0.43 | 4.68 | 0.05 | 0.30 | 0.01 | 0 | 0.02 |
Day 93 | 0067 | 0 | U | 10.92 | 16.8 | 48.4 | 49.0 | 44.3 | 15.4 | 34.7 | .287 | 2.6 | 720 | 5.49 | 0.68 | 4.36 | 0.07 | 0.34 | 0.02 | 0 | 0.03 |
Day 93 | 0068 | 0 | U | 10.48 | 16.0 | 46.6 | 47.3 | 44.4 | 15.3 | 34.4 | .263 | 2.5 | 1168 | 8.62 | 1.06 | 7.15 | 0.10 | 0.18 | 0.05 | 0 | 0.07 |
Day 93 | 0069 | 0 | U | 10.13 | 15.5 | 45.9 | 45.3 | 45.3 | 15.4 | 33.9 | .25 | 2.5 | 826 | 6.06 | 0.78 | 5.03 | 0.06 | 0.13 | 0.02 | 0 | 0.03 |
Day 93 | 0070 | 0 | U | 10.25 | 15.8 | 46.0 | 46.3 | 44.8 | 15.5 | 34.5 | .28 | 2.7 | 997 | 8.99 | 1.09 | 7.34 | 0.09 | 0.39 | 0.01 | 0 | 0.07 |
Day 93 | 0071 | 3125 | 10.52 | 16.1 | 47.7 | 47.8 | 45.3 | 15.3 | 33.8 | .177 | 1.7 | 1104 | 5.52 | 1.00 | 4.28 | 0.04 | 0.13 | 0.03 | 0 | 0.04 | |
Day 93 | 0072 | 3125 | 9.80 | 15.1 | 44.3 | 43.8 | 45.2 | 15.4 | 34.2 | .17 | 1.7 | 1184 | 4.79 | 0.68 | 3.84 | 0.07 | 0.15 | 0.01 | 0 | 0.03 | |
Day 93 | 0073 | 3125 | 11.12 | 17.1 | 50.5 | 50.3 | 45.4 | 15.3 | 33.8 | .322 | 2.9 | 361 | 4.65 | 0.49 | 4.00 | 0.04 | 0.08 | 0.02 | 0 | 0.02 | |
Day 93 | 0074 | 3125 | 10.89 | 16.9 | 49.0 | 48.5 | 45.0 | 15.5 | 34.4 | .243 | 2.2 | 820 | 5.34 | 0.80 | 3.78 | 0.05 | 0.65 | 0.02 | 0 | 0.04 | |
Day 93 | 0075 | 3125 | 10.63 | 16.4 | 48.1 | 47.3 | 45.2 | 15.4 | 34.0 | .256 | 2.4 | 965 | 3.22 | 0.40 | 2.54 | 0.03 | 0.23 | 0.01 | 0 | 0.02 | |
Day 93 | 0076 | 3125 | 10.08 | 15.7 | 45.8 | 45.5 | 45.5 | 15.6 | 34.4 | .234 | 2.3 | 1167 | 10.27 | 1.36 | 8.49 | 0.11 | 0.17 | 0.03 | 0 | 0.11 | |
Day 93 | 0077 | 3125 | 10.62 | 16.4 | 47.7 | 47.3 | 44.9 | 15.4 | 34.3 | .166 | 1.6 | 759 | 5.83 | 0.95 | 4.39 | 0.06 | 0.36 | 0.01 | 0 | 0.05 | |
Day 93 | 0078 | 3125 | 10.58 | 16.1 | 47.4 | 47.0 | 44.8 | 15.3 | 34.1 | .228 | 2.2 | 726 | 8.01 | 1.35 | 6.01 | 0.14 | 0.43 | 0.03 | 0 | 0.06 | |
Day 93 | 0079 | 3125 | 10.17 | 15.8 | 45.7 | 46.0 | 45.0 | 15.6 | 34.6 | .292 | 2.9 | 1253 | 9.49 | 1.53 | 7.54 | 0.07 | 0.25 | 0.02 | 0 | 0.08 | |
Day 93 | 0080 | 3125 | 10.68 | 16.3 | 47.8 | 48.0 | 44.7 | 15.3 | 34.2 | .27 | 2.5 | 858 | 7.16 | 1.01 | 5.79 | 0.07 | 0.22 | 0.03 | 0 | 0.04 | |
Day 93 | 0081 | 6250 | 9.72 | 15.1 | 44.5 | 45.3 | 45.7 | 15.5 | 33.9 | .271 | 2.8 | 1033 | 4.39 | 0.66 | 3.54 | 0.05 | 0.10 | 0.02 | 0 | 0.03 | |
Day 93 | 0082 | 6250 | 10.46 | 16.2 | 47.2 | 47.3 | 45.1 | 15.4 | 34.2 | .242 | 2.3 | 1032 | 6.97 | 0.72 | 5.85 | 0.10 | 0.25 | 0.02 | 0 | 0.05 | |
Day 93 | 0083 | 6250 | 9.77 | 14.9 | 44.2 | 44.5 | 45.2 | 15.3 | 33.8 | .256 | 2.6 | 1063 | 5.07 | 0.54 | 4.31 | 0.06 | 0.12 | 0.01 | 0 | 0.04 | |
Day 93 | 0084 | 6250 | 10.31 | 15.9 | 46.4 | 47.0 | 45.0 | 15.4 | 34.2 | .244 | 2.4 | 965 | 5.06 | 0.87 | 3.97 | 0.05 | 0.12 | 0.02 | 0 | 0.03 | |
Day 93 | 0085 | 6250 | 10.64 | 16.6 | 47.9 | 48.5 | 45.0 | 15.6 | 34.7 | .224 | 2.1 | 672 | 5.66 | 0.84 | 4.60 | 0.05 | 0.13 | 0.01 | 0 | 0.03 | |
Day 93 | 0086 | 6250 | 10.21 | 15.6 | 45.9 | 46.3 | 44.9 | 15.3 | 34.1 | .257 | 2.5 | 1005 | 10.40 | 1.67 | 8.38 | 0.09 | 0.14 | 0.04 | 0 | 0.08 | |
Day 93 | 0087 | 6250 | 10.34 | 15.8 | 46.9 | 47.0 | 45.3 | 15.3 | 33.6 | .355 | 3.4 | 1024 | 11.33 | 1.78 | 9.11 | 0.16 | 0.19 | 0.03 | 0 | 0.07 | |
Day 93 | 0088 | 6250 | 10.12 | 15.8 | 45.8 | 46.5 | 45.3 | 15.6 | 34.6 | .262 | 2.6 | 1103 | 9.26 | 1.34 | 7.54 | 0.12 | 0.17 | 0.03 | 0 | 0.05 | |
Day 93 | 0089 | 6250 | 10.27 | 15.5 | 45.5 | 46.0 | 44.3 | 15.1 | 34.0 | .224 | 2.2 | 1154 | 6.28 | 1.01 | 5.06 | 0.06 | 0.10 | 0.01 | 0 | 0.03 | |
Day 93 | 0090 | 6250 | 10.67 | 16.1 | 47.4 | 47.0 | 44.4 | 15.1 | 34.0 | .313 | 2.9 | 829 | 9.50 | 1.19 | 7.77 | 0.08 | 0.41 | 0.01 | 0 | 0.05 | |
Day 93 | 0091 | 12500 | 10.65 | 16.2 | 47.8 | 49.0 | 44.8 | 15.2 | 34.0 | .223 | 2.1 | 830 | 4.90 | 0.57 | 4.08 | 0.04 | 0.17 | 0.03 | 0 | 0.03 | |
Day 93 | 0092 | 12500 | 10.17 | 15.9 | 45.4 | 47.0 | 44.6 | 15.7 | 35.1 | .232 | 2.3 | 867 | 5.54 | 0.83 | 4.46 | 0.05 | 0.15 | 0.02 | 0 | 0.03 | |
Day 93 | 0093 | 12500 | 7.93 | 12.2 | 35.4 | 35.3 | 44.7 | 15.3 | 34.4 | .169 | 2.1 | 769 | 6.98 | 2.25 | 4.27 | 0.07 | 0.33 | 0.01 | 0 | 0.04 | |
Day 93 | 0094 | 12500 | 10.24 | 15.5 | 45.9 | 46.0 | 44.8 | 15.2 | 33.8 | .255 | 2.5 | 992 | 6.53 | 0.77 | 5.42 | 0.11 | 0.15 | 0.03 | 0 | 0.05 | |
Day 93 | 0095 | 12500 | 10.41 | 15.1 | 45.2 | 44.8 | 43.5 | 14.5 | 33.4 | .235 | 2.3 | 679 | 6.06 | 0.85 | 4.94 | 0.06 | 0.17 | 0.01 | 0 | 0.03 | |
Day 93 | 0096 | 12500 | 10.48 | 16.2 | 47.5 | 48.5 | 45.3 | 15.4 | 34.1 | .245 | 2.3 | 863 | 6.71 | 0.82 | 5.55 | 0.09 | 0.18 | 0.03 | 0 | 0.04 | |
Day 93 | 0097 | 12500 | 10.34 | 15.6 | 45.9 | 46.0 | 44.4 | 15.0 | 33.9 | .331 | 3.2 | 922 | 9.58 | 1.00 | 7.94 | 0.14 | 0.40 | 0.03 | 0 | 0.06 | |
Day 93 | 0098 | 12500 | 10.56 | 15.9 | 46.8 | 47.0 | 44.3 | 15.0 | 33.9 | .305 | 2.9 | 946 | 7.02 | 1.02 | 5.58 | 0.10 | 0.27 | 0.01 | 0 | 0.04 | |
Day 93 | 0099 | 12500 | 10.32 | 15.4 | 45.5 | 44.3 | 44.1 | 15.0 | 33.9 | .198 | 1.9 | 1190 | 7.99 | 0.94 | 6.62 | 0.10 | 0.23 | 0.03 | 0 | 0.07 | |
Day 93 | 0100 | 12500 | 10.18 | 15.7 | 45.9 | 47.3 | 45.1 | 15.4 | 34.2 | .166 | 1.6 | 728 | 5.75 | 0.62 | 4.87 | 0.08 | 0.14 | 0.01 | 0 | 0.04 | |
Day 93 | 0101 | 25000 | 10.24 | 15.3 | 46.2 | 47.0 | 45.1 | 14.9 | 33.1 | .26 | 2.5 | 1069 | 5.89 | 0.87 | 4.63 | 0.09 | 0.25 | 0.02 | 0 | 0.05 | |
Day 93 | 0102 | 25000 | 10.08 | 15.5 | 45.6 | 45.8 | 45.2 | 15.4 | 34.0 | .26 | 2.6 | 1045 | 7.12 | 1.02 | 5.74 | 0.05 | 0.24 | 0.02 | 0 | 0.05 | |
Day 93 | 0103 | 25000 | 9.63 | 14.8 | 43.8 | 43.8 | 45.5 | 15.4 | 33.8 | .251 | 2.6 | 1072 | 7.68 | 0.81 | 6.51 | 0.06 | 0.24 | 0.01 | 1 | 0.05 | |
Day 93 | 0104 | 25000 | 9.98 | 15.5 | 45.1 | 45.5 | 45.2 | 15.5 | 34.3 | .241 | 2.4 | 878 | 5.42 | 0.37 | 4.72 | 0.04 | 0.24 | 0.01 | 0 | 0.02 | |
Day 93 | 0105 | 25000 | 10.14 | 15.7 | 46.3 | 46.5 | 45.6 | 15.4 | 33.8 | .355 | 3.5 | 764 | 5.91 | 0.57 | 5.03 | 0.05 | 0.20 | 0.02 | 0 | 0.04 | |
Day 93 | 0106 | 25000 | 9.81 | 14.9 | 44.6 | 44.0 | 45.4 | 15.2 | 33.5 | .297 | 3.0 | 1154 | 9.18 | 0.80 | 7.97 | 0.11 | 0.16 | 0.06 | 0 | 0.07 | |
Day 93 | 0107 | 25000 | 10.19 | 15.7 | 46.3 | 47.0 | 45.4 | 15.4 | 34.0 | .333 | 3.3 | 1047 | 10.44 | 1.37 | 8.32 | 0.11 | 0.53 | 0.02 | 0 | 0.09 | |
Day 93 | 0108 | 25000 | 10.56 | 15.8 | 47.1 | 47.0 | 44.6 | 15.0 | 33.6 | .253 | 2.4 | 1041 | 6.21 | 0.73 | 5.13 | 0.09 | 0.20 | 0.01 | 0 | 0.05 | |
Day 93 | 0109 | 25000 | 10.07 | 15.4 | 45.2 | 45.8 | 44.9 | 15.3 | 34.1 | .244 | 2.4 | 1217 | 7.16 | 0.74 | 6.06 | 0.08 | 0.22 | 0.02 | 0 | 0.04 | |
Day 93 | 0110 | 25000 | 10.44 | 15.8 | 47.2 | 46.8 | 45.2 | 15.1 | 33.5 | .269 | 2.6 | 905 | 7.58 | 0.72 | 6.34 | 0.12 | 0.34 | 0.02 | 0 | 0.05 | |
Day 93 | 0111 | 50000 | 10.84 | 16.3 | 48.6 | 48.3 | 44.8 | 15.0 | 33.5 | .288 | 2.7 | 644 | 6.08 | 0.90 | 4.67 | 0.06 | 0.39 | 0.02 | 0 | 0.04 | |
Day 93 | 0112 | 50000 | 10.35 | 15.5 | 46.5 | 46.0 | 44.9 | 14.9 | 33.3 | .304 | 2.9 | 1164 | 7.61 | 1.20 | 6.08 | 0.08 | 0.16 | 0.02 | 0 | 0.07 | |
Day 93 | 0113 | 50000 | 10.43 | 15.8 | 47.0 | 46.3 | 45.0 | 15.1 | 33.6 | .211 | 2.0 | 1173 | 6.46 | 0.69 | 5.36 | 0.08 | 0.25 | 0.03 | 0 | 0.05 | |
Day 93 | 0114 | 50000 | 10.04 | 15.6 | 45.6 | 46.0 | 45.4 | 15.5 | 34.2 | .211 | 2.1 | 1128 | 4.84 | 0.76 | 3.93 | 0.03 | 0.08 | 0.01 | 0 | 0.04 | |
Day 93 | 0115 | 50000 | 11.04 | 16.5 | 48.5 | 48.0 | 44.0 | 15.0 | 34.0 | .312 | 2.8 | 881 | 10.12 | 1.44 | 7.87 | 0.08 | 0.63 | 0.04 | 0 | 0.07 | |
Day 93 | 0116 | 50000 | 10.78 | 16.3 | 46.9 | 47.3 | 43.5 | 15.1 | 34.7 | .263 | 2.4 | 835 | 7.19 | 0.90 | 5.75 | 0.05 | 0.43 | 0.01 | 0 | 0.04 | |
Day 93 | 0117 | 50000 | 11.09 | 16.5 | 49.3 | 49.0 | 44.4 | 14.9 | 33.5 | .291 | 2.6 | 760 | 8.40 | 0.81 | 7.07 | 0.08 | 0.37 | 0.02 | 0 | 0.05 | |
Day 93 | 0118 | 50000 | 11.03 | 16.3 | 47.8 | 47.5 | 43.3 | 14.8 | 34.1 | .303 | 2.8 | 661 | 7.94 | 1.18 | 6.08 | 0.08 | 0.51 | 0.03 | 0 | 0.06 | |
Day 93 | 0119 | 50000 | 10.53 | 16.0 | 47.3 | 46.0 | 44.9 | 15.2 | 33.8 | .295 | 2.8 | 1055 | 7.45 | 1.23 | 5.85 | 0.09 | 0.20 | 0.03 | 0 | 0.06 | |
Day 93 | 0120 | 50000 | 10.52 | 15.5 | 45.3 | 46.3 | 43.1 | 14.8 | 34.3 | .294 | 2.8 | 1080 | 7.40 | 1.11 | 5.99 | 0.06 | 0.18 | 0.02 | 0 | 0.04 | |
Abbreviations: | |||||||||||||||||||||
NA: Not Available, U: Untreated Control, Erythrcyt: Red Blood Cell Count, Hgb: Hemoglobin, HCT (Automated): Hematocrit, HCT (spun): Hematocrit Manual, MCV: Mean Corpuscular Volume, MCH: Mean Cell Hemoglobin, MCHC: Mean Cell Hemoglobin Concentration, Retics: Reticulocyte Count, Retics: Reticulocyte Percentage, Platelet: Platelet Count, Leukocytes: White Blood Cell Count, Neut: Neutrophil Count, Lymph: Lymphocyte Count, Mono: Monocyte Count, EOS: Eosinophil Count, Basophils: Basophil Count, NRBC: Nucleated Rbc Per 100 Wbc, LUC: Large Unstained Cells Count |