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Long-Term Study
Organ Weights Individual Animal
Study Information:
Chemical Name: | Milk thistle extract |
CASRN: | ="84604-20-6" |
Study Number: | C20008 |
Study Length (Year Completed): |
(N/A) |
Exposure Route: | |
TDMS Number: | 2000804 |
Sex: | Female |
Strain and Species: | B6C3F1 Mice |
Organ Weights Individual Animal Data |
Measurement Time |
Animal Number |
Dose Group (PPM) |
Control Code |
Final Body Weight |
Final Body Weight (g) |
Day 196 |
373 |
50000 |
|
|
|
Day 371 |
287 |
12500 |
|
29 |
|
Day 406 |
276 |
12500 |
|
|
|
Day 450 |
263 |
12500 |
|
24.4 |
|
Day 549 |
241 |
0 |
|
|
|
Day 560 |
202 |
0 |
|
25.9 |
|
Day 582 |
229 |
0 |
|
30.1 |
|
Day 602 |
340 |
25000 |
|
|
|
Day 618 |
206 |
0 |
|
24.4 |
|
Day 629 |
250 |
0 |
|
|
|
Day 632 |
354 |
50000 |
|
|
|
Day 637 |
328 |
25000 |
|
|
|
Day 644 |
224 |
0 |
|
|
|
Day 649 |
277 |
12500 |
|
|
|
Day 659 |
306 |
25000 |
|
14.1 |
|
Day 659 |
370 |
50000 |
|
27.6 |
|
Day 661 |
319 |
25000 |
|
|
|
Day 664 |
280 |
12500 |
|
|
|
Day 665 |
347 |
25000 |
|
|
|
Day 674 |
330 |
25000 |
|
|
|
Day 675 |
262 |
12500 |
|
|
|
Day 685 |
214 |
0 |
|
|
|
Day 688 |
317 |
25000 |
|
43.7 |
|
Day 688 |
368 |
50000 |
|
25.3 |
|
Day 697 |
333 |
25000 |
|
|
|
Day 705 |
242 |
0 |
|
|
|
Day 717 |
208 |
0 |
|
|
|
Day 721 |
355 |
50000 |
|
22.1 |
|
Day 725 |
289 |
12500 |
|
|
|
Day 728 |
221 |
0 |
|
|
|
Day 729 |
356 |
50000 |
|
36.9 |
|
Day 729 |
357 |
50000 |
|
46.7 |
|
Day 729 |
358 |
50000 |
|
37 |
|
Day 729 |
359 |
50000 |
|
35.1 |
|
Day 729 |
360 |
50000 |
|
34.1 |
|
Day 729 |
371 |
50000 |
|
33 |
|
Day 729 |
372 |
50000 |
|
34.4 |
|
Day 729 |
374 |
50000 |
|
32.9 |
|
Day 729 |
375 |
50000 |
|
32.5 |
|
Day 732 |
216 |
0 |
|
52 |
|
Day 732 |
217 |
0 |
|
56.4 |
|
Day 732 |
218 |
0 |
|
62.5 |
|
Day 732 |
219 |
0 |
|
35 |
|
Day 732 |
220 |
0 |
|
44 |
|
Day 732 |
226 |
0 |
|
48.3 |
|
Day 732 |
227 |
0 |
|
44.3 |
|
Day 732 |
228 |
0 |
|
59.7 |
|
Day 732 |
230 |
0 |
|
50 |
|
Day 732 |
231 |
0 |
|
45.6 |
|
Day 732 |
232 |
0 |
|
50 |
|
Day 732 |
233 |
0 |
|
37.1 |
|
Day 732 |
234 |
0 |
|
47.8 |
|
Day 732 |
235 |
0 |
|
44 |
|
Day 732 |
243 |
0 |
|
55.3 |
|
Day 732 |
244 |
0 |
|
48.2 |
|
Day 732 |
245 |
0 |
|
41.7 |
|
Day 732 |
246 |
0 |
|
52.6 |
|
Day 732 |
247 |
0 |
|
58.1 |
|
Day 732 |
248 |
0 |
|
64.5 |
|
Day 732 |
249 |
0 |
|
60.9 |
|
Day 732 |
281 |
12500 |
|
45.1 |
|
Day 732 |
282 |
12500 |
|
35.2 |
|
Day 732 |
283 |
12500 |
|
41.2 |
|
Day 732 |
284 |
12500 |
|
46.5 |
|
Day 732 |
285 |
12500 |
|
54.8 |
|
Day 732 |
296 |
12500 |
|
46 |
|
Day 732 |
297 |
12500 |
|
43.5 |
|
Day 732 |
298 |
12500 |
|
52.4 |
|
Day 732 |
299 |
12500 |
|
50.3 |
|
Day 732 |
300 |
12500 |
|
47.2 |
|
Day 732 |
307 |
25000 |
|
32.1 |
|
Day 732 |
308 |
25000 |
|
36.8 |
|
Day 732 |
309 |
25000 |
|
56.4 |
|
Day 732 |
310 |
25000 |
|
32.6 |
|
Day 732 |
321 |
25000 |
|
41.8 |
|
Day 732 |
322 |
25000 |
|
45.6 |
|
Day 732 |
323 |
25000 |
|
31.6 |
|
Day 732 |
324 |
25000 |
|
48.7 |
|
Day 732 |
325 |
25000 |
|
41.3 |
|
Day 732 |
336 |
25000 |
|
39.1 |
|
Day 732 |
337 |
25000 |
|
43.5 |
|
Day 732 |
338 |
25000 |
|
51.5 |
|
Day 732 |
339 |
25000 |
|
49.8 |
|
Day 733 |
288 |
12500 |
|
27.4 |
|
Day 735 |
201 |
0 |
|
45.7 |
|
Day 735 |
203 |
0 |
|
57.1 |
|
Day 735 |
204 |
0 |
|
47.8 |
|
Day 735 |
205 |
0 |
|
52.3 |
|
Day 735 |
207 |
0 |
|
47.1 |
|
Day 735 |
209 |
0 |
|
41.1 |
|
Day 735 |
210 |
0 |
|
49.8 |
|
Day 735 |
222 |
0 |
|
45.7 |
|
Day 735 |
223 |
0 |
|
51.4 |
|
Day 735 |
225 |
0 |
|
51.3 |
|
Day 735 |
236 |
0 |
|
58.4 |
|
Day 735 |
237 |
0 |
|
52.6 |
|
Day 735 |
238 |
0 |
|
52 |
|
Day 735 |
239 |
0 |
|
54.4 |
|
Day 735 |
240 |
0 |
|
53.2 |
|
Day 735 |
251 |
12500 |
|
46.9 |
|
Day 735 |
252 |
12500 |
|
40.9 |
|
Day 735 |
253 |
12500 |
|
46.9 |
|
Day 735 |
254 |
12500 |
|
38.2 |
|
Day 735 |
255 |
12500 |
|
44.5 |
|
Day 735 |
256 |
12500 |
|
38.5 |
|
Day 735 |
257 |
12500 |
|
48.3 |
|
Day 735 |
258 |
12500 |
|
47.6 |
|
Day 735 |
259 |
12500 |
|
45 |
|
Day 735 |
260 |
12500 |
|
48.2 |
|
Day 735 |
261 |
12500 |
|
46.4 |
|
Day 735 |
264 |
12500 |
|
40 |
|
Day 735 |
265 |
12500 |
|
54.7 |
|
Day 735 |
278 |
12500 |
|
46.4 |
|
Day 735 |
279 |
12500 |
|
45.7 |
|
Day 735 |
291 |
12500 |
|
43 |
|
Day 735 |
292 |
12500 |
|
43.8 |
|
Day 735 |
293 |
12500 |
|
44.4 |
|
Day 735 |
294 |
12500 |
|
53.1 |
|
Day 735 |
295 |
12500 |
|
54.4 |
|
Day 735 |
316 |
25000 |
|
39.8 |
|
Day 735 |
318 |
25000 |
|
36.2 |
|
Day 735 |
320 |
25000 |
|
50.9 |
|
Day 735 |
326 |
25000 |
|
49.7 |
|
Day 735 |
327 |
25000 |
|
48.3 |
|
Day 735 |
329 |
25000 |
|
43.6 |
|
Day 735 |
341 |
25000 |
|
44.6 |
|
Day 735 |
342 |
25000 |
|
39.4 |
|
Day 735 |
343 |
25000 |
|
46.6 |
|
Day 735 |
344 |
25000 |
|
35.5 |
|
Day 735 |
345 |
25000 |
|
50.8 |
|
Day 735 |
346 |
25000 |
|
43.1 |
|
Day 735 |
348 |
25000 |
|
46.9 |
|
Day 735 |
349 |
25000 |
|
45.9 |
|
Day 735 |
350 |
25000 |
|
53.3 |
|
Day 735 |
351 |
50000 |
|
41.1 |
|
Day 735 |
352 |
50000 |
|
46.6 |
|
Day 735 |
353 |
50000 |
|
41 |
|
Day 735 |
396 |
50000 |
|
38.2 |
|
Day 735 |
397 |
50000 |
|
56.2 |
|
Day 735 |
398 |
50000 |
|
41.7 |
|
Day 735 |
399 |
50000 |
|
35.1 |
|
Day 735 |
400 |
50000 |
|
37.8 |
|
Day 736 |
211 |
0 |
|
47.9 |
|
Day 736 |
212 |
0 |
|
50.8 |
|
Day 736 |
213 |
0 |
|
51.4 |
|
Day 736 |
215 |
0 |
|
47.2 |
|
Day 736 |
266 |
12500 |
|
43.9 |
|
Day 736 |
267 |
12500 |
|
47.4 |
|
Day 736 |
268 |
12500 |
|
35 |
|
Day 736 |
269 |
12500 |
|
45.1 |
|
Day 736 |
270 |
12500 |
|
45.9 |
|
Day 736 |
271 |
12500 |
|
|
|
Day 736 |
272 |
12500 |
|
53.9 |
|
Day 736 |
273 |
12500 |
|
55 |
|
Day 736 |
274 |
12500 |
|
51.1 |
|
Day 736 |
275 |
12500 |
|
59.9 |
|
Day 736 |
286 |
12500 |
|
43.8 |
|
Day 736 |
290 |
12500 |
|
59.2 |
|
Day 736 |
301 |
25000 |
|
38.8 |
|
Day 736 |
302 |
25000 |
|
28.8 |
|
Day 736 |
303 |
25000 |
|
41.2 |
|
Day 736 |
304 |
25000 |
|
41.6 |
|
Day 736 |
305 |
25000 |
|
43.8 |
|
Day 736 |
311 |
25000 |
|
40.1 |
|
Day 736 |
312 |
25000 |
|
38.7 |
|
Day 736 |
313 |
25000 |
|
33.5 |
|
Day 736 |
314 |
25000 |
|
42.2 |
|
Day 736 |
315 |
25000 |
|
45.1 |
|
Day 736 |
331 |
25000 |
|
54.9 |
|
Day 736 |
332 |
25000 |
|
41.4 |
|
Day 736 |
334 |
25000 |
|
50.6 |
|
Day 736 |
335 |
25000 |
|
35.1 |
|
Day 736 |
361 |
50000 |
|
51 |
|
Day 736 |
362 |
50000 |
|
41.9 |
|
Day 736 |
363 |
50000 |
|
31.9 |
|
Day 736 |
364 |
50000 |
|
40.9 |
|
Day 736 |
365 |
50000 |
|
39.6 |
|
Day 736 |
366 |
50000 |
|
34.5 |
|
Day 736 |
367 |
50000 |
|
30.2 |
|
Day 736 |
369 |
50000 |
|
35.7 |
|
Day 736 |
376 |
50000 |
|
29.7 |
|
Day 736 |
377 |
50000 |
|
33.2 |
|
Day 736 |
378 |
50000 |
|
36.2 |
|
Day 736 |
379 |
50000 |
|
32.8 |
|
Day 736 |
380 |
50000 |
|
32.8 |
|
Day 736 |
381 |
50000 |
|
29.1 |
|
Day 736 |
382 |
50000 |
|
32.7 |
|
Day 736 |
383 |
50000 |
|
31.3 |
|
Day 736 |
384 |
50000 |
|
35.9 |
|
Day 736 |
385 |
50000 |
|
33.3 |
|
Day 736 |
386 |
50000 |
|
35.9 |
|
Day 736 |
387 |
50000 |
|
31.3 |
|
Day 736 |
388 |
50000 |
|
43.4 |
|
Day 736 |
389 |
50000 |
|
32.8 |
|
Day 736 |
390 |
50000 |
|
32.5 |
|
Day 736 |
391 |
50000 |
|
40.8 |
|
Day 736 |
392 |
50000 |
|
40.8 |
|
Day 736 |
393 |
50000 |
|
30.5 |
|
Day 736 |
394 |
50000 |
|
31.6 |
|
Day 736 |
395 |
50000 |
|
27.2 |
|
Abbreviations: |
NA: Not Available
|