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Long-Term Study
Organ Weights Individual Animal
Study Information:
Chemical Name: | Milk thistle extract |
CASRN: | ="84604-20-6" |
Study Number: | C20008 |
Study Length (Year Completed): |
(N/A) |
Exposure Route: | |
TDMS Number: | 2000804 |
Sex: | Male |
Strain and Species: | B6C3F1 Mice |
Organ Weights Individual Animal Data |
Measurement Time |
Animal Number |
Dose Group (PPM) |
Control Code |
Final Body Weight |
Final Body Weight (g) |
Day 389 |
18 |
0 |
|
|
|
Day 427 |
24 |
0 |
|
|
|
Day 437 |
99 |
12500 |
|
18.7 |
|
Day 460 |
102 |
25000 |
|
|
|
Day 588 |
48 |
0 |
|
|
|
Day 633 |
85 |
12500 |
|
|
|
Day 638 |
115 |
25000 |
|
|
|
Day 642 |
75 |
12500 |
|
|
|
Day 657 |
119 |
25000 |
|
|
|
Day 659 |
132 |
25000 |
|
|
|
Day 663 |
112 |
25000 |
|
|
|
Day 693 |
142 |
25000 |
|
26 |
|
Day 693 |
155 |
50000 |
|
22.8 |
|
Day 699 |
7 |
0 |
|
|
|
Day 712 |
13 |
0 |
|
|
|
Day 712 |
113 |
25000 |
|
|
|
Day 716 |
86 |
12500 |
|
|
|
Day 729 |
11 |
0 |
|
48.6 |
|
Day 729 |
19 |
0 |
|
50.8 |
|
Day 729 |
22 |
0 |
|
35.1 |
|
Day 729 |
29 |
0 |
|
40.9 |
|
Day 729 |
34 |
0 |
|
55.2 |
|
Day 729 |
36 |
0 |
|
53.3 |
|
Day 729 |
42 |
0 |
|
51.7 |
|
Day 729 |
50 |
0 |
|
32.9 |
|
Day 729 |
63 |
12500 |
|
58 |
|
Day 729 |
66 |
12500 |
|
52.4 |
|
Day 729 |
70 |
12500 |
|
44 |
|
Day 729 |
71 |
12500 |
|
43.6 |
|
Day 729 |
72 |
12500 |
|
53.3 |
|
Day 729 |
78 |
12500 |
|
43.8 |
|
Day 729 |
81 |
12500 |
|
45.9 |
|
Day 729 |
82 |
12500 |
|
57 |
|
Day 729 |
95 |
12500 |
|
34.4 |
|
Day 729 |
97 |
12500 |
|
37.7 |
|
Day 729 |
101 |
25000 |
|
40.9 |
|
Day 729 |
103 |
25000 |
|
43.8 |
|
Day 729 |
104 |
25000 |
|
56 |
|
Day 729 |
120 |
25000 |
|
43 |
|
Day 729 |
121 |
25000 |
|
41 |
|
Day 729 |
125 |
25000 |
|
28.9 |
|
Day 729 |
126 |
25000 |
|
48.1 |
|
Day 729 |
130 |
25000 |
|
40.3 |
|
Day 729 |
136 |
25000 |
|
46.3 |
|
Day 729 |
140 |
25000 |
|
55.7 |
|
Day 729 |
143 |
25000 |
|
46.9 |
|
Day 729 |
144 |
25000 |
|
34.8 |
|
Day 729 |
148 |
25000 |
|
32.2 |
|
Day 729 |
150 |
25000 |
|
44.5 |
|
Day 729 |
156 |
50000 |
|
32.5 |
|
Day 729 |
163 |
50000 |
|
38 |
|
Day 729 |
170 |
50000 |
|
35.3 |
|
Day 729 |
172 |
50000 |
|
38.7 |
|
Day 729 |
173 |
50000 |
|
26.6 |
|
Day 729 |
181 |
50000 |
|
36.2 |
|
Day 729 |
185 |
50000 |
|
42.5 |
|
Day 729 |
187 |
50000 |
|
43.1 |
|
Day 729 |
190 |
50000 |
|
38.3 |
|
Day 729 |
192 |
50000 |
|
30.1 |
|
Day 729 |
195 |
50000 |
|
35 |
|
Day 730 |
14 |
0 |
|
56.9 |
|
Day 730 |
17 |
0 |
|
57.9 |
|
Day 730 |
2 |
0 |
|
53.4 |
|
Day 730 |
20 |
0 |
|
50.1 |
|
Day 730 |
26 |
0 |
|
37.9 |
|
Day 730 |
28 |
0 |
|
55.5 |
|
Day 730 |
31 |
0 |
|
45.3 |
|
Day 730 |
37 |
0 |
|
43 |
|
Day 730 |
38 |
0 |
|
55.8 |
|
Day 730 |
41 |
0 |
|
51.6 |
|
Day 730 |
44 |
0 |
|
49.4 |
|
Day 730 |
45 |
0 |
|
51.8 |
|
Day 730 |
46 |
0 |
|
37.7 |
|
Day 730 |
49 |
0 |
|
37.2 |
|
Day 730 |
5 |
0 |
|
41 |
|
Day 730 |
6 |
0 |
|
57 |
|
Day 730 |
9 |
0 |
|
54 |
|
Day 730 |
52 |
12500 |
|
39.9 |
|
Day 730 |
55 |
12500 |
|
52.6 |
|
Day 730 |
58 |
12500 |
|
39.4 |
|
Day 730 |
59 |
12500 |
|
52.3 |
|
Day 730 |
60 |
12500 |
|
47.5 |
|
Day 730 |
61 |
12500 |
|
42.7 |
|
Day 730 |
62 |
12500 |
|
41.7 |
|
Day 730 |
64 |
12500 |
|
38 |
|
Day 730 |
67 |
12500 |
|
43.2 |
|
Day 730 |
68 |
12500 |
|
35 |
|
Day 730 |
74 |
12500 |
|
42.4 |
|
Day 730 |
77 |
12500 |
|
55.2 |
|
Day 730 |
80 |
12500 |
|
42.1 |
|
Day 730 |
83 |
12500 |
|
37.8 |
|
Day 730 |
84 |
12500 |
|
33.2 |
|
Day 730 |
87 |
12500 |
|
46.7 |
|
Day 730 |
88 |
12500 |
|
42.8 |
|
Day 730 |
90 |
12500 |
|
45.4 |
|
Day 730 |
91 |
12500 |
|
39.2 |
|
Day 730 |
94 |
12500 |
|
37 |
|
Day 730 |
96 |
12500 |
|
40 |
|
Day 730 |
98 |
12500 |
|
53.3 |
|
Day 730 |
106 |
25000 |
|
40.3 |
|
Day 730 |
107 |
25000 |
|
46.9 |
|
Day 730 |
108 |
25000 |
|
44.5 |
|
Day 730 |
114 |
25000 |
|
39.2 |
|
Day 730 |
118 |
25000 |
|
45.6 |
|
Day 730 |
124 |
25000 |
|
48 |
|
Day 730 |
127 |
25000 |
|
49.5 |
|
Day 730 |
135 |
25000 |
|
47.8 |
|
Day 730 |
137 |
25000 |
|
43 |
|
Day 730 |
145 |
25000 |
|
52.7 |
|
Day 730 |
147 |
25000 |
|
46.3 |
|
Day 730 |
154 |
50000 |
|
42 |
|
Day 730 |
161 |
50000 |
|
39.2 |
|
Day 730 |
162 |
50000 |
|
32.3 |
|
Day 730 |
167 |
50000 |
|
41.7 |
|
Day 730 |
169 |
50000 |
|
39.6 |
|
Day 730 |
171 |
50000 |
|
37.5 |
|
Day 730 |
175 |
50000 |
|
34.7 |
|
Day 730 |
178 |
50000 |
|
39 |
|
Day 730 |
179 |
50000 |
|
43.8 |
|
Day 730 |
188 |
50000 |
|
42.1 |
|
Day 730 |
196 |
50000 |
|
40.5 |
|
Day 730 |
198 |
50000 |
|
28.2 |
|
Day 731 |
10 |
0 |
|
54.9 |
|
Day 731 |
12 |
0 |
|
41 |
|
Day 731 |
15 |
0 |
|
38.9 |
|
Day 731 |
16 |
0 |
|
47.2 |
|
Day 731 |
21 |
0 |
|
41.8 |
|
Day 731 |
25 |
0 |
|
44.7 |
|
Day 731 |
27 |
0 |
|
48.2 |
|
Day 731 |
3 |
0 |
|
52.8 |
|
Day 731 |
30 |
0 |
|
45.3 |
|
Day 731 |
33 |
0 |
|
34.4 |
|
Day 731 |
35 |
0 |
|
37.9 |
|
Day 731 |
4 |
0 |
|
29.7 |
|
Day 731 |
40 |
0 |
|
52 |
|
Day 731 |
47 |
0 |
|
55.6 |
|
Day 731 |
8 |
0 |
|
39.7 |
|
Day 731 |
100 |
12500 |
|
41.5 |
|
Day 731 |
53 |
12500 |
|
53.6 |
|
Day 731 |
54 |
12500 |
|
48.8 |
|
Day 731 |
56 |
12500 |
|
58.1 |
|
Day 731 |
57 |
12500 |
|
46.7 |
|
Day 731 |
65 |
12500 |
|
40.3 |
|
Day 731 |
69 |
12500 |
|
40.5 |
|
Day 731 |
73 |
12500 |
|
31.9 |
|
Day 731 |
89 |
12500 |
|
46.4 |
|
Day 731 |
92 |
12500 |
|
33.9 |
|
Day 731 |
93 |
12500 |
|
58.4 |
|
Day 731 |
105 |
25000 |
|
38 |
|
Day 731 |
109 |
25000 |
|
33 |
|
Day 731 |
110 |
25000 |
|
40.3 |
|
Day 731 |
111 |
25000 |
|
38.4 |
|
Day 731 |
116 |
25000 |
|
40.9 |
|
Day 731 |
117 |
25000 |
|
37.2 |
|
Day 731 |
123 |
25000 |
|
34.3 |
|
Day 731 |
129 |
25000 |
|
40.7 |
|
Day 731 |
131 |
25000 |
|
48.6 |
|
Day 731 |
133 |
25000 |
|
40.1 |
|
Day 731 |
134 |
25000 |
|
43.3 |
|
Day 731 |
138 |
25000 |
|
44.5 |
|
Day 731 |
139 |
25000 |
|
32.3 |
|
Day 731 |
149 |
25000 |
|
39.7 |
|
Day 731 |
151 |
50000 |
|
36.9 |
|
Day 731 |
152 |
50000 |
|
40.2 |
|
Day 731 |
153 |
50000 |
|
40.1 |
|
Day 731 |
157 |
50000 |
|
31.3 |
|
Day 731 |
158 |
50000 |
|
39 |
|
Day 731 |
159 |
50000 |
|
37.1 |
|
Day 731 |
164 |
50000 |
|
30.5 |
|
Day 731 |
165 |
50000 |
|
36.5 |
|
Day 731 |
166 |
50000 |
|
38.7 |
|
Day 731 |
168 |
50000 |
|
31.5 |
|
Day 731 |
174 |
50000 |
|
35.7 |
|
Day 731 |
177 |
50000 |
|
38 |
|
Day 731 |
180 |
50000 |
|
39.4 |
|
Day 731 |
182 |
50000 |
|
36 |
|
Day 731 |
183 |
50000 |
|
36.7 |
|
Day 731 |
186 |
50000 |
|
38.5 |
|
Day 731 |
189 |
50000 |
|
35.6 |
|
Day 731 |
191 |
50000 |
|
44.3 |
|
Day 731 |
193 |
50000 |
|
30.6 |
|
Day 731 |
194 |
50000 |
|
41.3 |
|
Day 731 |
197 |
50000 |
|
40.9 |
|
Day 731 |
199 |
50000 |
|
41.7 |
|
Day 732 |
1 |
0 |
|
53.7 |
|
Day 732 |
23 |
0 |
|
47.5 |
|
Day 732 |
32 |
0 |
|
53 |
|
Day 732 |
39 |
0 |
|
36.1 |
|
Day 732 |
43 |
0 |
|
39.2 |
|
Day 732 |
51 |
12500 |
|
46.1 |
|
Day 732 |
76 |
12500 |
|
41.5 |
|
Day 732 |
79 |
12500 |
|
39.7 |
|
Day 732 |
122 |
25000 |
|
32.8 |
|
Day 732 |
128 |
25000 |
|
42.4 |
|
Day 732 |
141 |
25000 |
|
44.1 |
|
Day 732 |
146 |
25000 |
|
46.1 |
|
Day 732 |
160 |
50000 |
|
40.5 |
|
Day 732 |
176 |
50000 |
|
43.2 |
|
Day 732 |
184 |
50000 |
|
45 |
|
Day 732 |
200 |
50000 |
|
43.1 |
|
Abbreviations: |
NA: Not Available
|