Alimentary System |
Esophagus |
Epithelium |
125 MG/KG |
10 |
42 |
42 |
93 |
1 |
Degeneration |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
250 MG/KG |
10 |
51 |
51 |
3 |
1 |
Fatty Change |
Mild |
Natural Death |
Alimentary System |
Liver |
Hepatocyte |
250 MG/KG |
10 |
52 |
52 |
3 |
1 |
Fatty Change |
Mild |
Natural Death |
Alimentary System |
Liver |
Hepatocyte |
250 MG/KG |
10 |
54 |
54 |
3 |
1 |
Fatty Change |
Mild |
Natural Death |
Alimentary System |
Liver |
Hepatocyte |
250 MG/KG |
10 |
55 |
55 |
3 |
1 |
Fatty Change |
Mild |
Natural Death |
Alimentary System |
Liver |
Hepatocyte |
250 MG/KG |
10 |
56 |
56 |
3 |
1 |
Fatty Change |
Mild |
Natural Death |
Alimentary System |
Liver |
Hepatocyte |
250 MG/KG |
10 |
57 |
57 |
5 |
1 |
Fatty Change |
Moderate |
Natural Death |
Alimentary System |
Liver |
Hepatocyte |
250 MG/KG |
10 |
58 |
58 |
3 |
1 |
Fatty Change |
Mild |
Natural Death |
Alimentary System |
Liver |
Hepatocyte |
250 MG/KG |
10 |
60 |
60 |
5 |
1 |
Fatty Change |
Moderate |
Natural Death |
Alimentary System |
Liver |
Hepatocyte |
250 MG/KG |
10 |
53 |
53 |
9 |
1 |
Necrosis |
Mild |
Natural Death |
Alimentary System |
Liver |
Hepatocyte |
250 MG/KG |
10 |
55 |
55 |
3 |
1 |
Necrosis |
Mild |
Natural Death |
Alimentary System |
Liver |
Hepatocyte |
250 MG/KG |
10 |
57 |
57 |
5 |
1 |
Necrosis |
Mild |
Natural Death |
Alimentary System |
Liver |
Hepatocyte |
250 MG/KG |
10 |
60 |
60 |
5 |
1 |
Necrosis |
Mild |
Natural Death |
Alimentary System |
Liver |
Hepatocyte |
Vehicle Control |
10 |
1 |
1 |
93 |
1 |
Vacuolization Cytoplasmic |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
Vehicle Control |
10 |
10 |
10 |
93 |
1 |
Vacuolization Cytoplasmic |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
Vehicle Control |
10 |
2 |
2 |
93 |
1 |
Vacuolization Cytoplasmic |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
Vehicle Control |
10 |
3 |
3 |
93 |
1 |
Vacuolization Cytoplasmic |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
Vehicle Control |
10 |
5 |
5 |
93 |
1 |
Vacuolization Cytoplasmic |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
Vehicle Control |
10 |
6 |
6 |
93 |
1 |
Vacuolization Cytoplasmic |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
Vehicle Control |
10 |
7 |
7 |
93 |
1 |
Vacuolization Cytoplasmic |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
Vehicle Control |
10 |
8 |
8 |
93 |
1 |
Vacuolization Cytoplasmic |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
Vehicle Control |
10 |
9 |
9 |
93 |
1 |
Vacuolization Cytoplasmic |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
15 MG/KG |
10 |
11 |
11 |
93 |
1 |
Vacuolization Cytoplasmic |
Moderate |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
15 MG/KG |
10 |
12 |
12 |
93 |
1 |
Vacuolization Cytoplasmic |
Moderate |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
15 MG/KG |
10 |
13 |
13 |
93 |
1 |
Vacuolization Cytoplasmic |
Moderate |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
15 MG/KG |
10 |
14 |
14 |
93 |
1 |
Vacuolization Cytoplasmic |
Moderate |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
15 MG/KG |
10 |
15 |
15 |
93 |
1 |
Vacuolization Cytoplasmic |
Moderate |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
15 MG/KG |
10 |
16 |
16 |
93 |
1 |
Vacuolization Cytoplasmic |
Moderate |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
15 MG/KG |
10 |
17 |
17 |
93 |
1 |
Vacuolization Cytoplasmic |
Moderate |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
15 MG/KG |
10 |
18 |
18 |
93 |
1 |
Vacuolization Cytoplasmic |
Moderate |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
15 MG/KG |
10 |
19 |
19 |
93 |
1 |
Vacuolization Cytoplasmic |
Moderate |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
15 MG/KG |
10 |
20 |
20 |
93 |
1 |
Vacuolization Cytoplasmic |
Moderate |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
30 MG/KG |
10 |
21 |
21 |
93 |
1 |
Vacuolization Cytoplasmic |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
30 MG/KG |
10 |
22 |
22 |
93 |
1 |
Vacuolization Cytoplasmic |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
30 MG/KG |
10 |
23 |
23 |
93 |
1 |
Vacuolization Cytoplasmic |
Moderate |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
30 MG/KG |
10 |
24 |
24 |
93 |
1 |
Vacuolization Cytoplasmic |
Moderate |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
30 MG/KG |
10 |
26 |
26 |
93 |
1 |
Vacuolization Cytoplasmic |
Moderate |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
30 MG/KG |
10 |
27 |
27 |
93 |
1 |
Vacuolization Cytoplasmic |
Moderate |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
30 MG/KG |
10 |
28 |
28 |
93 |
1 |
Vacuolization Cytoplasmic |
Marked |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
30 MG/KG |
10 |
29 |
29 |
93 |
1 |
Vacuolization Cytoplasmic |
Moderate |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
30 MG/KG |
10 |
30 |
30 |
93 |
1 |
Vacuolization Cytoplasmic |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
60 MG/KG |
10 |
31 |
31 |
93 |
1 |
Vacuolization Cytoplasmic |
Moderate |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
60 MG/KG |
10 |
32 |
32 |
93 |
1 |
Vacuolization Cytoplasmic |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
60 MG/KG |
10 |
33 |
33 |
93 |
1 |
Vacuolization Cytoplasmic |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
60 MG/KG |
10 |
34 |
34 |
93 |
1 |
Vacuolization Cytoplasmic |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
60 MG/KG |
10 |
35 |
35 |
93 |
1 |
Vacuolization Cytoplasmic |
Moderate |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
60 MG/KG |
10 |
36 |
36 |
93 |
1 |
Vacuolization Cytoplasmic |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
60 MG/KG |
10 |
37 |
37 |
93 |
1 |
Vacuolization Cytoplasmic |
Moderate |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
60 MG/KG |
10 |
38 |
38 |
93 |
1 |
Vacuolization Cytoplasmic |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
60 MG/KG |
10 |
39 |
39 |
93 |
1 |
Vacuolization Cytoplasmic |
Marked |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
60 MG/KG |
10 |
40 |
40 |
93 |
1 |
Vacuolization Cytoplasmic |
Moderate |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
125 MG/KG |
10 |
41 |
41 |
93 |
1 |
Vacuolization Cytoplasmic |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
125 MG/KG |
10 |
42 |
42 |
93 |
1 |
Vacuolization Cytoplasmic |
Moderate |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
125 MG/KG |
10 |
44 |
44 |
93 |
1 |
Vacuolization Cytoplasmic |
Moderate |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
125 MG/KG |
10 |
46 |
46 |
93 |
1 |
Vacuolization Cytoplasmic |
Moderate |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
125 MG/KG |
10 |
47 |
47 |
93 |
1 |
Vacuolization Cytoplasmic |
Moderate |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
125 MG/KG |
10 |
48 |
48 |
93 |
1 |
Vacuolization Cytoplasmic |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
125 MG/KG |
10 |
50 |
50 |
93 |
1 |
Vacuolization Cytoplasmic |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
250 MG/KG |
10 |
59 |
59 |
93 |
1 |
Vacuolization Cytoplasmic |
Moderate |
Terminal Sacrifice |
Alimentary System |
Liver |
|
30 MG/KG |
10 |
24 |
24 |
93 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
|
60 MG/KG |
10 |
31 |
31 |
93 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
1 |
1 |
93 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
10 |
10 |
93 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
2 |
2 |
93 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
3 |
3 |
93 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
4 |
4 |
93 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
6 |
6 |
93 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
7 |
7 |
93 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
8 |
8 |
93 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
9 |
9 |
93 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Liver |
|
15 MG/KG |
10 |
11 |
11 |
93 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Liver |
|
15 MG/KG |
10 |
12 |
12 |
93 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Liver |
|
15 MG/KG |
10 |
13 |
13 |
93 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Liver |
|
15 MG/KG |
10 |
14 |
14 |
93 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Liver |
|
15 MG/KG |
10 |
15 |
15 |
93 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Liver |
|
15 MG/KG |
10 |
16 |
16 |
93 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Liver |
|
15 MG/KG |
10 |
17 |
17 |
93 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Liver |
|
15 MG/KG |
10 |
18 |
18 |
93 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Liver |
|
15 MG/KG |
10 |
19 |
19 |
93 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Liver |
|
15 MG/KG |
10 |
20 |
20 |
93 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Liver |
|
30 MG/KG |
10 |
21 |
21 |
93 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Liver |
|
30 MG/KG |
10 |
22 |
22 |
93 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Liver |
|
30 MG/KG |
10 |
23 |
23 |
93 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Liver |
|
30 MG/KG |
10 |
24 |
24 |
93 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Liver |
|
30 MG/KG |
10 |
25 |
25 |
93 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Liver |
|
30 MG/KG |
10 |
26 |
26 |
93 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Liver |
|
30 MG/KG |
10 |
27 |
27 |
93 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Liver |
|
30 MG/KG |
10 |
28 |
28 |
93 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Liver |
|
30 MG/KG |
10 |
29 |
29 |
93 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Liver |
|
30 MG/KG |
10 |
30 |
30 |
93 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Liver |
|
60 MG/KG |
10 |
31 |
31 |
93 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Liver |
|
60 MG/KG |
10 |
32 |
32 |
93 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Liver |
|
60 MG/KG |
10 |
33 |
33 |
93 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Liver |
|
60 MG/KG |
10 |
34 |
34 |
93 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Liver |
|
60 MG/KG |
10 |
35 |
35 |
93 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Liver |
|
60 MG/KG |
10 |
36 |
36 |
93 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Liver |
|
60 MG/KG |
10 |
37 |
37 |
93 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Liver |
|
60 MG/KG |
10 |
38 |
38 |
93 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Liver |
|
60 MG/KG |
10 |
39 |
39 |
93 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Liver |
|
60 MG/KG |
10 |
40 |
40 |
93 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Liver |
|
125 MG/KG |
10 |
41 |
41 |
93 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Liver |
|
125 MG/KG |
10 |
42 |
42 |
93 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Liver |
|
125 MG/KG |
10 |
44 |
44 |
93 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Liver |
|
125 MG/KG |
10 |
46 |
46 |
93 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Liver |
|
125 MG/KG |
10 |
47 |
47 |
93 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Liver |
|
125 MG/KG |
10 |
48 |
48 |
93 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Liver |
|
125 MG/KG |
10 |
50 |
50 |
93 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Liver |
|
250 MG/KG |
10 |
59 |
59 |
93 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Liver |
|
250 MG/KG |
10 |
55 |
55 |
3 |
1 |
Tension Lipidosis |
Mild |
Natural Death |
Alimentary System |
Mesentery |
Artery, Fat |
125 MG/KG |
1 |
43 |
43 |
77 |
1 |
Thrombosis |
Marked |
Moribund Sacrifice |
Alimentary System |
Mesentery |
Fat |
125 MG/KG |
1 |
43 |
43 |
77 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Alimentary System |
Mesentery |
Fat |
125 MG/KG |
1 |
43 |
43 |
77 |
1 |
Necrosis |
Marked |
Moribund Sacrifice |
Alimentary System |
Stomach |
Glandular |
Vehicle Control |
10 |
8 |
8 |
93 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Tooth |
|
Vehicle Control |
1 |
9 |
9 |
93 |
1 |
Malformation |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
125 MG/KG |
10 |
43 |
43 |
77 |
1 |
Mineralization |
Minimal |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
250 MG/KG |
10 |
53 |
53 |
9 |
1 |
Mineralization |
Minimal |
Natural Death |
Cardiovascular System |
Heart |
|
250 MG/KG |
10 |
60 |
60 |
5 |
1 |
Mineralization |
Minimal |
Natural Death |
Endocrine System |
Adrenal Cortex |
Subcapsular |
Vehicle Control |
10 |
1 |
1 |
93 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
Subcapsular |
Vehicle Control |
10 |
2 |
2 |
93 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
Subcapsular |
125 MG/KG |
10 |
41 |
41 |
93 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
Subcapsular |
125 MG/KG |
10 |
47 |
47 |
93 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
125 MG/KG |
10 |
43 |
43 |
77 |
1 |
Accessory Adrenal Cortical Nodule |
Minimal |
Moribund Sacrifice |
Endocrine System |
Adrenal Cortex |
|
250 MG/KG |
10 |
52 |
52 |
3 |
1 |
Accessory Adrenal Cortical Nodule |
Mild |
Natural Death |
Genital System |
Coagulating Gland |
|
125 MG/KG |
1 |
43 |
43 |
77 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Genital System |
Epididymis |
|
125 MG/KG |
10 |
43 |
43 |
77 |
1 |
Inflammation |
Moderate, Chronic Active |
Moribund Sacrifice |
Genital System |
Epididymis |
|
125 MG/KG |
10 |
43 |
43 |
77 |
1 |
Necrosis |
Moderate |
Moribund Sacrifice |
Genital System |
Preputial Gland |
|
125 MG/KG |
10 |
43 |
43 |
77 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Genital System |
Preputial Gland |
|
125 MG/KG |
10 |
43 |
43 |
77 |
1 |
Necrosis |
Marked |
Moribund Sacrifice |
Genital System |
Prostate |
|
125 MG/KG |
10 |
43 |
43 |
77 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Genital System |
Prostate |
|
125 MG/KG |
10 |
43 |
43 |
77 |
1 |
Necrosis |
Marked |
Moribund Sacrifice |
Genital System |
Seminal Vesicle |
|
125 MG/KG |
10 |
43 |
43 |
77 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Genital System |
Testes |
Germinal Epith |
125 MG/KG |
10 |
43 |
43 |
77 |
1 |
Degeneration |
Mild |
Moribund Sacrifice |
Hematopoietic System |
Lymph Node |
Bronchial |
250 MG/KG |
10 |
58 |
58 |
3 |
1 |
Atrophy |
Mild |
Natural Death |
Hematopoietic System |
Lymph Node |
Inguinal |
250 MG/KG |
10 |
51 |
51 |
3 |
1 |
Necrosis |
Mild, Lymphoid |
Natural Death |
Hematopoietic System |
Lymph Node |
Mandibular |
125 MG/KG |
10 |
45 |
45 |
8 |
1 |
Atrophy |
Mild |
Natural Death |
Hematopoietic System |
Lymph Node |
Mandibular |
125 MG/KG |
10 |
49 |
49 |
9 |
1 |
Atrophy |
Mild |
Natural Death |
Hematopoietic System |
Lymph Node |
Mandibular |
250 MG/KG |
10 |
53 |
53 |
9 |
1 |
Atrophy |
Mild |
Natural Death |
Hematopoietic System |
Lymph Node |
Mandibular |
250 MG/KG |
10 |
57 |
57 |
5 |
1 |
Atrophy |
Mild |
Natural Death |
Hematopoietic System |
Lymph Node |
Mandibular |
250 MG/KG |
10 |
51 |
51 |
3 |
1 |
Necrosis |
Mild, Lymphoid |
Natural Death |
Hematopoietic System |
Lymph Node |
Mandibular |
250 MG/KG |
10 |
52 |
52 |
3 |
1 |
Necrosis |
Mild, Lymphoid |
Natural Death |
Hematopoietic System |
Lymph Node |
Mandibular |
250 MG/KG |
10 |
54 |
54 |
3 |
1 |
Necrosis |
Mild, Lymphoid |
Natural Death |
Hematopoietic System |
Lymph Node |
Mandibular |
250 MG/KG |
10 |
55 |
55 |
3 |
1 |
Necrosis |
Mild, Lymphoid |
Natural Death |
Hematopoietic System |
Lymph Node |
Mandibular |
250 MG/KG |
10 |
56 |
56 |
3 |
1 |
Necrosis |
Mild, Lymphoid |
Natural Death |
Hematopoietic System |
Lymph Node |
Mesenteric |
125 MG/KG |
10 |
45 |
45 |
8 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Lymph Node |
Mesenteric |
125 MG/KG |
10 |
50 |
50 |
93 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
250 MG/KG |
10 |
57 |
57 |
5 |
1 |
Atrophy |
Mild |
Natural Death |
Hematopoietic System |
Lymph Node |
Mesenteric |
250 MG/KG |
10 |
58 |
58 |
3 |
1 |
Atrophy |
Mild |
Natural Death |
Hematopoietic System |
Lymph Node |
Mesenteric |
250 MG/KG |
10 |
51 |
51 |
3 |
1 |
Necrosis |
Mild, Lymphoid |
Natural Death |
Hematopoietic System |
Lymph Node |
Mesenteric |
250 MG/KG |
10 |
52 |
52 |
3 |
1 |
Necrosis |
Mild, Lymphoid |
Natural Death |
Hematopoietic System |
Lymph Node |
Mesenteric |
250 MG/KG |
10 |
54 |
54 |
3 |
1 |
Necrosis |
Mild, Lymphoid |
Natural Death |
Hematopoietic System |
Lymph Node |
Mesenteric |
250 MG/KG |
10 |
55 |
55 |
3 |
1 |
Necrosis |
Mild, Lymphoid |
Natural Death |
Hematopoietic System |
Lymph Node |
Mesenteric |
250 MG/KG |
10 |
56 |
56 |
3 |
1 |
Necrosis |
Minimal, Lymphoid |
Natural Death |
Hematopoietic System |
Spleen |
Lymph Follic |
250 MG/KG |
10 |
51 |
51 |
3 |
1 |
Necrosis |
Mild |
Natural Death |
Hematopoietic System |
Spleen |
Lymph Follic |
250 MG/KG |
10 |
52 |
52 |
3 |
1 |
Necrosis |
Mild |
Natural Death |
Hematopoietic System |
Spleen |
Lymph Follic |
250 MG/KG |
10 |
54 |
54 |
3 |
1 |
Necrosis |
Mild |
Natural Death |
Hematopoietic System |
Spleen |
Lymph Follic |
250 MG/KG |
10 |
55 |
55 |
3 |
1 |
Necrosis |
Mild |
Natural Death |
Hematopoietic System |
Spleen |
Lymph Follic |
250 MG/KG |
10 |
56 |
56 |
3 |
1 |
Necrosis |
Mild |
Natural Death |
Hematopoietic System |
Spleen |
Lymph Follic |
250 MG/KG |
10 |
58 |
58 |
3 |
1 |
Necrosis |
Moderate |
Natural Death |
Hematopoietic System |
Spleen |
|
125 MG/KG |
10 |
43 |
43 |
77 |
1 |
Atrophy |
Moderate |
Moribund Sacrifice |
Hematopoietic System |
Spleen |
|
125 MG/KG |
10 |
45 |
45 |
8 |
1 |
Atrophy |
Moderate |
Natural Death |
Hematopoietic System |
Spleen |
|
125 MG/KG |
10 |
49 |
49 |
9 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Spleen |
|
250 MG/KG |
10 |
51 |
51 |
3 |
1 |
Atrophy |
Moderate |
Natural Death |
Hematopoietic System |
Spleen |
|
250 MG/KG |
10 |
52 |
52 |
3 |
1 |
Atrophy |
Moderate |
Natural Death |
Hematopoietic System |
Spleen |
|
250 MG/KG |
10 |
53 |
53 |
9 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Spleen |
|
250 MG/KG |
10 |
54 |
54 |
3 |
1 |
Atrophy |
Mild |
Natural Death |
Hematopoietic System |
Spleen |
|
250 MG/KG |
10 |
56 |
56 |
3 |
1 |
Atrophy |
Moderate |
Natural Death |
Hematopoietic System |
Spleen |
|
250 MG/KG |
10 |
57 |
57 |
5 |
1 |
Atrophy |
Moderate |
Natural Death |
Hematopoietic System |
Spleen |
|
250 MG/KG |
10 |
58 |
58 |
3 |
1 |
Atrophy |
Moderate |
Natural Death |
Hematopoietic System |
Spleen |
|
250 MG/KG |
10 |
60 |
60 |
5 |
1 |
Atrophy |
Moderate |
Natural Death |
Hematopoietic System |
Spleen |
|
125 MG/KG |
10 |
44 |
44 |
93 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
Thymocyte |
125 MG/KG |
10 |
43 |
43 |
77 |
1 |
Necrosis |
Mild |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
Thymocyte |
125 MG/KG |
10 |
41 |
41 |
93 |
1 |
Necrosis |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
Thymocyte |
125 MG/KG |
10 |
42 |
42 |
93 |
1 |
Necrosis |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
Thymocyte |
125 MG/KG |
10 |
44 |
44 |
93 |
1 |
Necrosis |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
Thymocyte |
125 MG/KG |
10 |
46 |
46 |
93 |
1 |
Necrosis |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
Thymocyte |
125 MG/KG |
10 |
47 |
47 |
93 |
1 |
Necrosis |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
Thymocyte |
125 MG/KG |
10 |
48 |
48 |
93 |
1 |
Necrosis |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
Thymocyte |
125 MG/KG |
10 |
50 |
50 |
93 |
1 |
Necrosis |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
Thymocyte |
250 MG/KG |
10 |
51 |
51 |
3 |
1 |
Necrosis |
Marked |
Natural Death |
Hematopoietic System |
Thymus |
Thymocyte |
250 MG/KG |
10 |
52 |
52 |
3 |
1 |
Necrosis |
Marked |
Natural Death |
Hematopoietic System |
Thymus |
Thymocyte |
250 MG/KG |
10 |
54 |
54 |
3 |
1 |
Necrosis |
Marked |
Natural Death |
Hematopoietic System |
Thymus |
Thymocyte |
250 MG/KG |
10 |
55 |
55 |
3 |
1 |
Necrosis |
Marked |
Natural Death |
Hematopoietic System |
Thymus |
Thymocyte |
250 MG/KG |
10 |
56 |
56 |
3 |
1 |
Necrosis |
Marked |
Natural Death |
Hematopoietic System |
Thymus |
Thymocyte |
250 MG/KG |
10 |
58 |
58 |
3 |
1 |
Necrosis |
Marked |
Natural Death |
Hematopoietic System |
Thymus |
Thymocyte |
250 MG/KG |
10 |
60 |
60 |
5 |
1 |
Necrosis |
Mild |
Natural Death |
Hematopoietic System |
Thymus |
|
125 MG/KG |
10 |
43 |
43 |
77 |
1 |
Atrophy |
Moderate |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
125 MG/KG |
10 |
45 |
45 |
8 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Thymus |
|
125 MG/KG |
10 |
49 |
49 |
9 |
1 |
Atrophy |
Moderate |
Natural Death |
Hematopoietic System |
Thymus |
|
250 MG/KG |
10 |
53 |
53 |
9 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Thymus |
|
250 MG/KG |
10 |
57 |
57 |
5 |
1 |
Atrophy |
Moderate |
Natural Death |
Hematopoietic System |
Thymus |
|
250 MG/KG |
10 |
60 |
60 |
5 |
1 |
Atrophy |
Moderate |
Natural Death |
Integumentary System |
Skin |
Subcut Tiss |
125 MG/KG |
10 |
43 |
43 |
77 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Integumentary System |
Skin |
Subcut Tiss |
125 MG/KG |
10 |
43 |
43 |
77 |
1 |
Necrosis |
Marked |
Moribund Sacrifice |
Respiratory System |
Lung |
Alveolus |
125 MG/KG |
10 |
47 |
47 |
93 |
1 |
Infiltration Cellular |
Mild, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolus |
125 MG/KG |
10 |
50 |
50 |
93 |
1 |
Infiltration Cellular |
Mild, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
Bronchiole, Epithelium |
60 MG/KG |
10 |
36 |
36 |
93 |
1 |
Degeneration |
Mild |
Terminal Sacrifice |
Respiratory System |
Lung |
Bronchiole, Epithelium |
125 MG/KG |
10 |
43 |
43 |
77 |
1 |
Degeneration |
Moderate |
Moribund Sacrifice |
Respiratory System |
Lung |
Bronchiole, Epithelium |
125 MG/KG |
10 |
45 |
45 |
8 |
1 |
Degeneration |
Marked |
Natural Death |
Respiratory System |
Lung |
Bronchiole, Epithelium |
125 MG/KG |
10 |
49 |
49 |
9 |
1 |
Degeneration |
Marked |
Natural Death |
Respiratory System |
Lung |
Bronchiole, Epithelium |
125 MG/KG |
10 |
41 |
41 |
93 |
1 |
Degeneration |
Moderate |
Terminal Sacrifice |
Respiratory System |
Lung |
Bronchiole, Epithelium |
125 MG/KG |
10 |
42 |
42 |
93 |
1 |
Degeneration |
Moderate |
Terminal Sacrifice |
Respiratory System |
Lung |
Bronchiole, Epithelium |
125 MG/KG |
10 |
44 |
44 |
93 |
1 |
Degeneration |
Moderate |
Terminal Sacrifice |
Respiratory System |
Lung |
Bronchiole, Epithelium |
125 MG/KG |
10 |
46 |
46 |
93 |
1 |
Degeneration |
Moderate |
Terminal Sacrifice |
Respiratory System |
Lung |
Bronchiole, Epithelium |
125 MG/KG |
10 |
47 |
47 |
93 |
1 |
Degeneration |
Moderate |
Terminal Sacrifice |
Respiratory System |
Lung |
Bronchiole, Epithelium |
125 MG/KG |
10 |
48 |
48 |
93 |
1 |
Degeneration |
Minimal |
Terminal Sacrifice |
Respiratory System |
Lung |
Bronchiole, Epithelium |
125 MG/KG |
10 |
50 |
50 |
93 |
1 |
Degeneration |
Minimal |
Terminal Sacrifice |
Respiratory System |
Lung |
Bronchiole, Epithelium |
250 MG/KG |
10 |
52 |
52 |
3 |
1 |
Degeneration |
Moderate |
Natural Death |
Respiratory System |
Lung |
Bronchiole, Epithelium |
250 MG/KG |
10 |
53 |
53 |
9 |
1 |
Degeneration |
Marked |
Natural Death |
Respiratory System |
Lung |
Bronchiole, Epithelium |
250 MG/KG |
10 |
54 |
54 |
3 |
1 |
Degeneration |
Mild |
Natural Death |
Respiratory System |
Lung |
Bronchiole, Epithelium |
250 MG/KG |
10 |
55 |
55 |
3 |
1 |
Degeneration |
Mild |
Natural Death |
Respiratory System |
Lung |
Bronchiole, Epithelium |
250 MG/KG |
10 |
57 |
57 |
5 |
1 |
Degeneration |
Mild |
Natural Death |
Respiratory System |
Lung |
Bronchiole, Epithelium |
250 MG/KG |
10 |
58 |
58 |
3 |
1 |
Degeneration |
Moderate |
Natural Death |
Respiratory System |
Lung |
Bronchiole, Epithelium |
250 MG/KG |
10 |
60 |
60 |
5 |
1 |
Degeneration |
Marked |
Natural Death |
Respiratory System |
Lung |
Bronchiole, Epithelium |
250 MG/KG |
10 |
59 |
59 |
93 |
1 |
Degeneration |
Marked |
Terminal Sacrifice |
Respiratory System |
Lung |
Bronchiole, Epithelium |
60 MG/KG |
10 |
36 |
36 |
93 |
1 |
Regeneration |
Mild |
Terminal Sacrifice |
Respiratory System |
Lung |
Bronchiole, Epithelium |
125 MG/KG |
10 |
43 |
43 |
77 |
1 |
Regeneration |
Moderate |
Moribund Sacrifice |
Respiratory System |
Lung |
Bronchiole, Epithelium |
125 MG/KG |
10 |
45 |
45 |
8 |
1 |
Regeneration |
Mild |
Natural Death |
Respiratory System |
Lung |
Bronchiole, Epithelium |
125 MG/KG |
10 |
41 |
41 |
93 |
1 |
Regeneration |
Moderate |
Terminal Sacrifice |
Respiratory System |
Lung |
Bronchiole, Epithelium |
125 MG/KG |
10 |
42 |
42 |
93 |
1 |
Regeneration |
Moderate |
Terminal Sacrifice |
Respiratory System |
Lung |
Bronchiole, Epithelium |
125 MG/KG |
10 |
44 |
44 |
93 |
1 |
Regeneration |
Moderate |
Terminal Sacrifice |
Respiratory System |
Lung |
Bronchiole, Epithelium |
125 MG/KG |
10 |
46 |
46 |
93 |
1 |
Regeneration |
Moderate |
Terminal Sacrifice |
Respiratory System |
Lung |
Bronchiole, Epithelium |
125 MG/KG |
10 |
47 |
47 |
93 |
1 |
Regeneration |
Moderate |
Terminal Sacrifice |
Respiratory System |
Lung |
Bronchiole, Epithelium |
125 MG/KG |
10 |
48 |
48 |
93 |
1 |
Regeneration |
Minimal |
Terminal Sacrifice |
Respiratory System |
Lung |
Bronchiole, Epithelium |
125 MG/KG |
10 |
50 |
50 |
93 |
1 |
Regeneration |
Moderate |
Terminal Sacrifice |
Respiratory System |
Lung |
Bronchiole, Epithelium |
250 MG/KG |
10 |
53 |
53 |
9 |
1 |
Regeneration |
Marked |
Natural Death |
Respiratory System |
Lung |
Bronchiole, Epithelium |
250 MG/KG |
10 |
60 |
60 |
5 |
1 |
Regeneration |
Mild |
Natural Death |
Respiratory System |
Lung |
Bronchiole, Epithelium |
250 MG/KG |
10 |
59 |
59 |
93 |
1 |
Regeneration |
Marked |
Terminal Sacrifice |
Respiratory System |
Lung |
Bronchus, Epithelium |
125 MG/KG |
10 |
49 |
49 |
9 |
1 |
Regeneration |
Moderate |
Natural Death |
Respiratory System |
Lung |
Peribronchiolr |
125 MG/KG |
10 |
43 |
43 |
77 |
1 |
Inflammation |
Mild, Chronic Active |
Moribund Sacrifice |
Respiratory System |
Lung |
Peribronchiolr |
125 MG/KG |
10 |
45 |
45 |
8 |
1 |
Inflammation |
Moderate, Chronic Active |
Natural Death |
Respiratory System |
Lung |
Peribronchiolr |
125 MG/KG |
10 |
49 |
49 |
9 |
1 |
Inflammation |
Marked, Chronic Active |
Natural Death |
Respiratory System |
Lung |
Peribronchiolr |
125 MG/KG |
10 |
41 |
41 |
93 |
1 |
Inflammation |
Moderate, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
Peribronchiolr |
125 MG/KG |
10 |
42 |
42 |
93 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
Peribronchiolr |
125 MG/KG |
10 |
44 |
44 |
93 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
Peribronchiolr |
125 MG/KG |
10 |
46 |
46 |
93 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
Peribronchiolr |
125 MG/KG |
10 |
47 |
47 |
93 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
Peribronchiolr |
125 MG/KG |
10 |
50 |
50 |
93 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
Peribronchiolr |
250 MG/KG |
10 |
52 |
52 |
3 |
1 |
Inflammation |
Minimal, Chronic Active |
Natural Death |
Respiratory System |
Lung |
Peribronchiolr |
250 MG/KG |
10 |
53 |
53 |
9 |
1 |
Inflammation |
Mild, Chronic Active |
Natural Death |
Respiratory System |
Lung |
Peribronchiolr |
250 MG/KG |
10 |
56 |
56 |
3 |
1 |
Inflammation |
Minimal, Chronic Active |
Natural Death |
Respiratory System |
Lung |
Peribronchiolr |
250 MG/KG |
10 |
57 |
57 |
5 |
1 |
Inflammation |
Mild, Chronic Active |
Natural Death |
Respiratory System |
Lung |
Peribronchiolr |
250 MG/KG |
10 |
58 |
58 |
3 |
1 |
Inflammation |
Mild, Chronic Active |
Natural Death |
Respiratory System |
Lung |
Peribronchiolr |
250 MG/KG |
10 |
60 |
60 |
5 |
1 |
Inflammation |
Mild, Chronic Active |
Natural Death |
Respiratory System |
Nose |
Glands |
125 MG/KG |
10 |
41 |
41 |
93 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Glands |
125 MG/KG |
10 |
42 |
42 |
93 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Glands |
125 MG/KG |
10 |
44 |
44 |
93 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Glands |
125 MG/KG |
10 |
46 |
46 |
93 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Glands |
125 MG/KG |
10 |
47 |
47 |
93 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Glands |
125 MG/KG |
10 |
48 |
48 |
93 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Glands |
125 MG/KG |
10 |
50 |
50 |
93 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Glands |
250 MG/KG |
10 |
59 |
59 |
93 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
125 MG/KG |
10 |
43 |
43 |
77 |
1 |
Degeneration |
Marked |
Moribund Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
125 MG/KG |
10 |
45 |
45 |
8 |
1 |
Degeneration |
Moderate |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
125 MG/KG |
10 |
41 |
41 |
93 |
1 |
Degeneration |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
125 MG/KG |
10 |
42 |
42 |
93 |
1 |
Degeneration |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
125 MG/KG |
10 |
44 |
44 |
93 |
1 |
Degeneration |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
125 MG/KG |
10 |
46 |
46 |
93 |
1 |
Degeneration |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
125 MG/KG |
10 |
47 |
47 |
93 |
1 |
Degeneration |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
125 MG/KG |
10 |
48 |
48 |
93 |
1 |
Degeneration |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
125 MG/KG |
10 |
50 |
50 |
93 |
1 |
Degeneration |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
250 MG/KG |
10 |
53 |
53 |
9 |
1 |
Degeneration |
Mild |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
250 MG/KG |
10 |
59 |
59 |
93 |
1 |
Degeneration |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
125 MG/KG |
10 |
41 |
41 |
93 |
1 |
Metaplasia |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
125 MG/KG |
10 |
42 |
42 |
93 |
1 |
Metaplasia |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
125 MG/KG |
10 |
44 |
44 |
93 |
1 |
Metaplasia |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
125 MG/KG |
10 |
46 |
46 |
93 |
1 |
Metaplasia |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
125 MG/KG |
10 |
48 |
48 |
93 |
1 |
Metaplasia |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
125 MG/KG |
10 |
50 |
50 |
93 |
1 |
Metaplasia |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
250 MG/KG |
10 |
59 |
59 |
93 |
1 |
Metaplasia |
Marked |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
250 MG/KG |
10 |
57 |
57 |
5 |
1 |
Necrosis |
Marked |
Natural Death |
Respiratory System |
Nose |
Respirat Epith |
125 MG/KG |
10 |
43 |
43 |
77 |
1 |
Degeneration |
Mild |
Moribund Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
250 MG/KG |
10 |
51 |
51 |
3 |
1 |
Degeneration |
Mild |
Natural Death |
Respiratory System |
Nose |
Respirat Epith |
250 MG/KG |
10 |
57 |
57 |
5 |
1 |
Necrosis |
Marked |
Natural Death |
Respiratory System |
Nose |
|
250 MG/KG |
10 |
59 |
59 |
93 |
1 |
Foreign Body |
|
Terminal Sacrifice |
Respiratory System |
Nose |
|
125 MG/KG |
10 |
49 |
49 |
9 |
1 |
Inflammation |
Minimal, Chronic Active |
Natural Death |
Respiratory System |
Nose |
|
250 MG/KG |
10 |
51 |
51 |
3 |
1 |
Inflammation |
Mild, Chronic Active |
Natural Death |
Respiratory System |
Nose |
|
250 MG/KG |
10 |
52 |
52 |
3 |
1 |
Inflammation |
Mild, Chronic Active |
Natural Death |
Respiratory System |
Nose |
|
250 MG/KG |
10 |
53 |
53 |
9 |
1 |
Inflammation |
Moderate, Chronic Active |
Natural Death |
Respiratory System |
Nose |
|
250 MG/KG |
10 |
54 |
54 |
3 |
1 |
Inflammation |
Mild, Chronic Active |
Natural Death |
Respiratory System |
Nose |
|
250 MG/KG |
10 |
55 |
55 |
3 |
1 |
Inflammation |
Mild, Chronic Active |
Natural Death |
Respiratory System |
Nose |
|
250 MG/KG |
10 |
56 |
56 |
3 |
1 |
Inflammation |
Mild, Chronic Active |
Natural Death |
Respiratory System |
Nose |
|
250 MG/KG |
10 |
58 |
58 |
3 |
1 |
Inflammation |
Mild, Chronic Active |
Natural Death |
Respiratory System |
Nose |
|
250 MG/KG |
10 |
60 |
60 |
5 |
1 |
Inflammation |
Moderate, Chronic Active |
Natural Death |
Respiratory System |
Trachea |
Epithelium |
125 MG/KG |
10 |
42 |
42 |
93 |
1 |
Degeneration |
Minimal |
Terminal Sacrifice |
Respiratory System |
Trachea |
Epithelium |
125 MG/KG |
10 |
44 |
44 |
93 |
1 |
Degeneration |
Minimal |
Terminal Sacrifice |
Respiratory System |
Trachea |
Epithelium |
125 MG/KG |
10 |
49 |
49 |
9 |
1 |
Hyperplasia |
Marked |
Natural Death |
Respiratory System |
Trachea |
Epithelium |
125 MG/KG |
10 |
43 |
43 |
77 |
1 |
Necrosis |
Marked |
Moribund Sacrifice |
Respiratory System |
Trachea |
Epithelium |
125 MG/KG |
10 |
45 |
45 |
8 |
1 |
Necrosis |
Marked |
Natural Death |
Respiratory System |
Trachea |
Epithelium |
250 MG/KG |
10 |
51 |
51 |
3 |
1 |
Necrosis |
Marked |
Natural Death |
Respiratory System |
Trachea |
Epithelium |
250 MG/KG |
10 |
52 |
52 |
3 |
1 |
Necrosis |
Marked |
Natural Death |
Respiratory System |
Trachea |
Epithelium |
250 MG/KG |
10 |
54 |
54 |
3 |
1 |
Necrosis |
Marked |
Natural Death |
Respiratory System |
Trachea |
Epithelium |
250 MG/KG |
10 |
55 |
55 |
3 |
1 |
Necrosis |
Marked |
Natural Death |
Respiratory System |
Trachea |
Epithelium |
250 MG/KG |
10 |
56 |
56 |
3 |
1 |
Necrosis |
Marked |
Natural Death |
Respiratory System |
Trachea |
Epithelium |
250 MG/KG |
10 |
57 |
57 |
5 |
1 |
Necrosis |
Marked |
Natural Death |
Respiratory System |
Trachea |
Epithelium |
250 MG/KG |
10 |
58 |
58 |
3 |
1 |
Necrosis |
Marked |
Natural Death |
Respiratory System |
Trachea |
Epithelium |
250 MG/KG |
10 |
60 |
60 |
5 |
1 |
Necrosis |
Marked |
Natural Death |
Respiratory System |
Trachea |
|
250 MG/KG |
10 |
53 |
53 |
9 |
1 |
Inflammation |
Mild, Chronic |
Natural Death |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
4 |
4 |
93 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Urinary System |
Kidney |
|
60 MG/KG |
10 |
31 |
31 |
93 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Urinary System |
Kidney |
|
250 MG/KG |
10 |
59 |
59 |
93 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
7 |
7 |
93 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
125 MG/KG |
10 |
43 |
43 |
77 |
1 |
Mineralization |
Minimal |
Moribund Sacrifice |
Urinary System |
Kidney |
|
250 MG/KG |
10 |
60 |
60 |
5 |
1 |
Mineralization |
Minimal |
Natural Death |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
10 |
10 |
93 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
60 MG/KG |
10 |
33 |
33 |
93 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
125 MG/KG |
10 |
46 |
46 |
93 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
125 MG/KG |
10 |
48 |
48 |
93 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |