If this is the first time you are viewing this file, please choose 'Save As' from the 'File' menu
and resave this file as an Excel file type. This will greatly speed up future viewings of this file.
Short-Term Individual Animal Non Neoplastic Diagnosis
Study Information:
Chemical Name: | Nanoscale material (Fullerene-C60 1 micron) |
CASRN: | ="99685-96-8" |
Study Number: | C20701 |
Exposure Route: | RESPIRATORY EXPOSURE NASAL |
TDMS Number: | 2070102 |
Sex: | Male |
Strain and Species: | B6C3F1 Mice |
Male Individual Animal Non Neoplastic Diagnoses
System |
Organ |
Site |
Treatment Group |
Number Examined |
Cage Number |
Animal Number |
Days on Study |
Lesion Found |
Lesion Name |
Lesion Qualifier |
Removal Reason |
Alimentary System |
Liver |
|
30 mg/m3 |
10 |
68 |
1608 |
89 |
1 |
Inflammation |
Minimal, Granulomatous |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
4 |
1004 |
89 |
1 |
Necrosis |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
2 mg/m3 |
1 |
27 |
1207 |
63 |
1 |
Hyperplasia |
Mild, Squamous |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach |
2 mg/m3 |
1 |
27 |
1207 |
63 |
1 |
Ulcer |
Minimal |
Moribund Sacrifice |
Genital System |
Testes |
Germinal Epith |
15 mg/m3 |
10 |
48 |
1408 |
89 |
1 |
Degeneration |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Bronchial |
Vehicle Control |
10 |
1 |
1001 |
89 |
1 |
Pigmentation |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Bronchial |
Vehicle Control |
10 |
6 |
1006 |
89 |
1 |
Pigmentation |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Bronchial |
2 mg/m3 |
10 |
29 |
1209 |
89 |
1 |
Pigmentation |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Bronchial |
15 mg/m3 |
10 |
41 |
1401 |
89 |
1 |
Pigmentation |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Bronchial |
15 mg/m3 |
10 |
42 |
1402 |
89 |
1 |
Pigmentation |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Bronchial |
30 mg/m3 |
10 |
61 |
1601 |
89 |
1 |
Pigmentation |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Bronchial |
30 mg/m3 |
10 |
62 |
1602 |
89 |
1 |
Pigmentation |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Bronchial |
30 mg/m3 |
10 |
63 |
1603 |
89 |
1 |
Pigmentation |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Bronchial |
30 mg/m3 |
10 |
64 |
1604 |
89 |
1 |
Pigmentation |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Bronchial |
30 mg/m3 |
10 |
66 |
1606 |
89 |
1 |
Pigmentation |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Bronchial |
30 mg/m3 |
10 |
67 |
1607 |
89 |
1 |
Pigmentation |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Bronchial |
30 mg/m3 |
10 |
68 |
1608 |
89 |
1 |
Pigmentation |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Bronchial |
30 mg/m3 |
10 |
69 |
1609 |
89 |
1 |
Pigmentation |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Bronchial |
30 mg/m3 |
10 |
70 |
1610 |
89 |
1 |
Pigmentation |
Mild |
Terminal Sacrifice |
Respiratory System |
Larynx |
Squam Epithel |
2 mg/m3 |
10 |
27 |
1207 |
63 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Respiratory System |
Larynx |
|
Vehicle Control |
10 |
10 |
1010 |
89 |
1 |
Metaplasia |
Minimal, Squamous |
Terminal Sacrifice |
Respiratory System |
Larynx |
|
15 mg/m3 |
10 |
43 |
1403 |
89 |
1 |
Metaplasia |
Minimal, Squamous |
Terminal Sacrifice |
Respiratory System |
Larynx |
|
15 mg/m3 |
10 |
45 |
1405 |
89 |
1 |
Metaplasia |
Minimal, Squamous |
Terminal Sacrifice |
Respiratory System |
Larynx |
|
15 mg/m3 |
10 |
47 |
1407 |
89 |
1 |
Metaplasia |
Minimal, Squamous |
Terminal Sacrifice |
Respiratory System |
Larynx |
|
15 mg/m3 |
10 |
48 |
1408 |
89 |
1 |
Metaplasia |
Minimal, Squamous |
Terminal Sacrifice |
Respiratory System |
Larynx |
|
15 mg/m3 |
10 |
49 |
1409 |
89 |
1 |
Metaplasia |
Minimal, Squamous |
Terminal Sacrifice |
Respiratory System |
Larynx |
|
30 mg/m3 |
10 |
61 |
1601 |
89 |
1 |
Metaplasia |
Minimal, Squamous |
Terminal Sacrifice |
Respiratory System |
Larynx |
|
30 mg/m3 |
10 |
62 |
1602 |
89 |
1 |
Metaplasia |
Minimal, Squamous |
Terminal Sacrifice |
Respiratory System |
Larynx |
|
30 mg/m3 |
10 |
63 |
1603 |
89 |
1 |
Metaplasia |
Minimal, Squamous |
Terminal Sacrifice |
Respiratory System |
Larynx |
|
30 mg/m3 |
10 |
65 |
1605 |
89 |
1 |
Metaplasia |
Minimal, Squamous |
Terminal Sacrifice |
Respiratory System |
Larynx |
|
30 mg/m3 |
10 |
66 |
1606 |
89 |
1 |
Metaplasia |
Mild, Squamous |
Terminal Sacrifice |
Respiratory System |
Larynx |
|
30 mg/m3 |
10 |
67 |
1607 |
89 |
1 |
Metaplasia |
Minimal, Squamous |
Terminal Sacrifice |
Respiratory System |
Larynx |
|
30 mg/m3 |
10 |
68 |
1608 |
89 |
1 |
Metaplasia |
Minimal, Squamous |
Terminal Sacrifice |
Respiratory System |
Larynx |
|
30 mg/m3 |
10 |
69 |
1609 |
89 |
1 |
Metaplasia |
Minimal, Squamous |
Terminal Sacrifice |
Respiratory System |
Larynx |
|
30 mg/m3 |
10 |
70 |
1610 |
89 |
1 |
Metaplasia |
Minimal, Squamous |
Terminal Sacrifice |
Respiratory System |
Lung |
|
2 mg/m3 |
10 |
26 |
1206 |
89 |
1 |
Hemorrhage |
Minimal |
Terminal Sacrifice |
Respiratory System |
Lung |
|
15 mg/m3 |
10 |
41 |
1401 |
89 |
1 |
Infiltration Cellular |
Marked, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
|
15 mg/m3 |
10 |
42 |
1402 |
89 |
1 |
Infiltration Cellular |
Marked, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
|
15 mg/m3 |
10 |
43 |
1403 |
89 |
1 |
Infiltration Cellular |
Moderate, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
|
15 mg/m3 |
10 |
44 |
1404 |
89 |
1 |
Infiltration Cellular |
Marked, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
|
15 mg/m3 |
10 |
45 |
1405 |
89 |
1 |
Infiltration Cellular |
Mild, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
|
15 mg/m3 |
10 |
46 |
1406 |
89 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
|
15 mg/m3 |
10 |
47 |
1407 |
89 |
1 |
Infiltration Cellular |
Mild, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
|
15 mg/m3 |
10 |
48 |
1408 |
89 |
1 |
Infiltration Cellular |
Mild, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
|
15 mg/m3 |
10 |
49 |
1409 |
89 |
1 |
Infiltration Cellular |
Moderate, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
|
15 mg/m3 |
10 |
50 |
1410 |
89 |
1 |
Infiltration Cellular |
Marked, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
|
30 mg/m3 |
10 |
61 |
1601 |
89 |
1 |
Infiltration Cellular |
Marked, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
|
30 mg/m3 |
10 |
62 |
1602 |
89 |
1 |
Infiltration Cellular |
Marked, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
|
30 mg/m3 |
10 |
63 |
1603 |
89 |
1 |
Infiltration Cellular |
Marked, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
|
30 mg/m3 |
10 |
64 |
1604 |
89 |
1 |
Infiltration Cellular |
Moderate, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
|
30 mg/m3 |
10 |
65 |
1605 |
89 |
1 |
Infiltration Cellular |
Marked, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
|
30 mg/m3 |
10 |
66 |
1606 |
89 |
1 |
Infiltration Cellular |
Marked, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
|
30 mg/m3 |
10 |
67 |
1607 |
89 |
1 |
Infiltration Cellular |
Marked, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
|
30 mg/m3 |
10 |
68 |
1608 |
89 |
1 |
Infiltration Cellular |
Marked, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
|
30 mg/m3 |
10 |
69 |
1609 |
89 |
1 |
Infiltration Cellular |
Marked, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
|
30 mg/m3 |
10 |
70 |
1610 |
89 |
1 |
Infiltration Cellular |
Marked, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
|
15 mg/m3 |
10 |
41 |
1401 |
89 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
15 mg/m3 |
10 |
42 |
1402 |
89 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
15 mg/m3 |
10 |
43 |
1403 |
89 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
15 mg/m3 |
10 |
44 |
1404 |
89 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
15 mg/m3 |
10 |
45 |
1405 |
89 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
15 mg/m3 |
10 |
46 |
1406 |
89 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
15 mg/m3 |
10 |
47 |
1407 |
89 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
15 mg/m3 |
10 |
48 |
1408 |
89 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
15 mg/m3 |
10 |
49 |
1409 |
89 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
15 mg/m3 |
10 |
50 |
1410 |
89 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
30 mg/m3 |
10 |
61 |
1601 |
89 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
30 mg/m3 |
10 |
62 |
1602 |
89 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
30 mg/m3 |
10 |
63 |
1603 |
89 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
30 mg/m3 |
10 |
64 |
1604 |
89 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
30 mg/m3 |
10 |
65 |
1605 |
89 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
30 mg/m3 |
10 |
66 |
1606 |
89 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
30 mg/m3 |
10 |
67 |
1607 |
89 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
30 mg/m3 |
10 |
68 |
1608 |
89 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
30 mg/m3 |
10 |
69 |
1609 |
89 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
30 mg/m3 |
10 |
70 |
1610 |
89 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
15 mg/m3 |
10 |
41 |
1401 |
89 |
1 |
Pigmentation |
Marked |
Terminal Sacrifice |
Respiratory System |
Lung |
|
15 mg/m3 |
10 |
42 |
1402 |
89 |
1 |
Pigmentation |
Marked |
Terminal Sacrifice |
Respiratory System |
Lung |
|
15 mg/m3 |
10 |
43 |
1403 |
89 |
1 |
Pigmentation |
Moderate |
Terminal Sacrifice |
Respiratory System |
Lung |
|
15 mg/m3 |
10 |
44 |
1404 |
89 |
1 |
Pigmentation |
Mild |
Terminal Sacrifice |
Respiratory System |
Lung |
|
15 mg/m3 |
10 |
45 |
1405 |
89 |
1 |
Pigmentation |
Moderate |
Terminal Sacrifice |
Respiratory System |
Lung |
|
15 mg/m3 |
10 |
46 |
1406 |
89 |
1 |
Pigmentation |
Moderate |
Terminal Sacrifice |
Respiratory System |
Lung |
|
15 mg/m3 |
10 |
47 |
1407 |
89 |
1 |
Pigmentation |
Moderate |
Terminal Sacrifice |
Respiratory System |
Lung |
|
15 mg/m3 |
10 |
48 |
1408 |
89 |
1 |
Pigmentation |
Moderate |
Terminal Sacrifice |
Respiratory System |
Lung |
|
15 mg/m3 |
10 |
49 |
1409 |
89 |
1 |
Pigmentation |
Moderate |
Terminal Sacrifice |
Respiratory System |
Lung |
|
15 mg/m3 |
10 |
50 |
1410 |
89 |
1 |
Pigmentation |
Marked |
Terminal Sacrifice |
Respiratory System |
Lung |
|
30 mg/m3 |
10 |
61 |
1601 |
89 |
1 |
Pigmentation |
Marked |
Terminal Sacrifice |
Respiratory System |
Lung |
|
30 mg/m3 |
10 |
62 |
1602 |
89 |
1 |
Pigmentation |
Marked |
Terminal Sacrifice |
Respiratory System |
Lung |
|
30 mg/m3 |
10 |
63 |
1603 |
89 |
1 |
Pigmentation |
Marked |
Terminal Sacrifice |
Respiratory System |
Lung |
|
30 mg/m3 |
10 |
64 |
1604 |
89 |
1 |
Pigmentation |
Moderate |
Terminal Sacrifice |
Respiratory System |
Lung |
|
30 mg/m3 |
10 |
65 |
1605 |
89 |
1 |
Pigmentation |
Marked |
Terminal Sacrifice |
Respiratory System |
Lung |
|
30 mg/m3 |
10 |
66 |
1606 |
89 |
1 |
Pigmentation |
Marked |
Terminal Sacrifice |
Respiratory System |
Lung |
|
30 mg/m3 |
10 |
67 |
1607 |
89 |
1 |
Pigmentation |
Marked |
Terminal Sacrifice |
Respiratory System |
Lung |
|
30 mg/m3 |
10 |
68 |
1608 |
89 |
1 |
Pigmentation |
Marked |
Terminal Sacrifice |
Respiratory System |
Lung |
|
30 mg/m3 |
10 |
69 |
1609 |
89 |
1 |
Pigmentation |
Marked |
Terminal Sacrifice |
Respiratory System |
Lung |
|
30 mg/m3 |
10 |
70 |
1610 |
89 |
1 |
Pigmentation |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
30 mg/m3 |
10 |
67 |
1607 |
89 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
30 mg/m3 |
10 |
64 |
1604 |
89 |
1 |
Accumulation, Hyaline Droplet |
Minimal |
Terminal Sacrifice |
Special Senses System |
Harderian Gland |
|
Vehicle Control |
10 |
1 |
1001 |
89 |
1 |
Inflammation |
Mild, Acute |
Terminal Sacrifice |
Special Senses System |
Harderian Gland |
|
Vehicle Control |
10 |
10 |
1010 |
89 |
1 |
Inflammation |
Mild, Acute |
Terminal Sacrifice |
Special Senses System |
Harderian Gland |
|
Vehicle Control |
10 |
2 |
1002 |
89 |
1 |
Inflammation |
Minimal, Acute |
Terminal Sacrifice |
Special Senses System |
Harderian Gland |
|
Vehicle Control |
10 |
3 |
1003 |
89 |
1 |
Inflammation |
Minimal, Acute |
Terminal Sacrifice |
Special Senses System |
Harderian Gland |
|
Vehicle Control |
10 |
4 |
1004 |
89 |
1 |
Inflammation |
Moderate, Acute |
Terminal Sacrifice |
Special Senses System |
Harderian Gland |
|
Vehicle Control |
10 |
5 |
1005 |
89 |
1 |
Inflammation |
Mild, Acute |
Terminal Sacrifice |
Special Senses System |
Harderian Gland |
|
Vehicle Control |
10 |
8 |
1008 |
89 |
1 |
Inflammation |
Mild, Acute |
Terminal Sacrifice |
Special Senses System |
Harderian Gland |
|
30 mg/m3 |
10 |
61 |
1601 |
89 |
1 |
Inflammation |
Minimal, Acute |
Terminal Sacrifice |
Special Senses System |
Harderian Gland |
|
30 mg/m3 |
10 |
64 |
1604 |
89 |
1 |
Inflammation |
Mild, Acute |
Terminal Sacrifice |
Special Senses System |
Harderian Gland |
|
30 mg/m3 |
10 |
66 |
1606 |
89 |
1 |
Inflammation |
Minimal, Acute |
Terminal Sacrifice |
Special Senses System |
Harderian Gland |
|
30 mg/m3 |
10 |
67 |
1607 |
89 |
1 |
Inflammation |
Mild, Acute |
Terminal Sacrifice |
Special Senses System |
Harderian Gland |
|
30 mg/m3 |
10 |
68 |
1608 |
89 |
1 |
Inflammation |
Minimal, Acute |
Terminal Sacrifice |
Special Senses System |
Harderian Gland |
|
30 mg/m3 |
10 |
69 |
1609 |
89 |
1 |
Inflammation |
Mild, Acute |
Terminal Sacrifice |
Special Senses System |
Harderian Gland |
|
30 mg/m3 |
10 |
70 |
1610 |
89 |
1 |
Inflammation |
Minimal, Acute |
Terminal Sacrifice |
Urinary System |
Kidney |
Papilla |
Vehicle Control |
10 |
7 |
1007 |
89 |
1 |
Infiltration Cellular |
Mild, Polymorphnuclr |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
Vehicle Control |
10 |
9 |
1009 |
89 |
1 |
Necrosis |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
15 mg/m3 |
10 |
44 |
1404 |
89 |
1 |
Necrosis |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
30 mg/m3 |
10 |
62 |
1602 |
89 |
1 |
Necrosis |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
30 mg/m3 |
10 |
63 |
1603 |
89 |
1 |
Necrosis |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
30 mg/m3 |
10 |
69 |
1609 |
89 |
1 |
Necrosis |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
3 |
1003 |
89 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
2 mg/m3 |
10 |
24 |
1204 |
89 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
2 mg/m3 |
10 |
29 |
1209 |
89 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
30 mg/m3 |
10 |
64 |
1604 |
89 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
30 mg/m3 |
10 |
68 |
1608 |
89 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |