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Chemical Name: | Riddelliine |
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CASRN: | ="23246-96-0" |
Study Number: | C20328 |
Study Length (Year Completed): | 24 hour (N/A) |
Exposure Route: | GAV |
TDMS Number: | 2032802.ss |
Sex: | Male |
Strain and Species: | Fischer 344 Rats |
Clinical Chemistry Individual Animal Data | |||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Measurement Time | Animal Number | Dose Group (mg/kg) | Control Code | BUN (mg_dL) | Creat (U per L) | TP (g_dL) | ALB (g_dL) | ALT (IU_L) | SDH (IU_L) | AST (IU per L) | LDH (IU PER L) | ALP (IU_L) | TBA (umol per g) | Tot Bilirubin (mg per dL) | Dir Bilirubin (mg per dL) | Cholesterol (mg per dL) | Triglyceride (mg per dL) |
Hour 3 | 0001 | 0 | V | 16 | 0.2 | 7.9 | 3.1 | 62 | 2.7 | 92 | 285 | 329 | 4.4 | 0.3 | 0.1 | 63 | 124 |
Hour 3 | 0002 | 0 | V | 15 | 0.4 | 7.1 | 3.1 | 57 | 2.5 | 85 | 321 | 323 | 3.3 | 0.2 | 0.1 | 63 | 90 |
Hour 3 | 0003 | 0 | V | 13 | 0.3 | 7.1 | 3.7 | 43 | 1.3 | 70 | 204 | 325 | 3.7 | 0.3 | 0.1 | 58 | 112 |
Hour 3 | 0004 | 0 | V | 13 | 0.2 | 6.7 | 3.3 | 39 | 2.8 | 74 | 190 | 324 | 4.1 | 0.3 | 0.1 | 39 | 126 |
Hour 3 | 0005 | 0 | V | 16 | 0.3 | 6.5 | 3.1 | 44 | 4.9 | 76 | 229 | 283 | 5.1 | 0.2 | 0.1 | 65 | 93 |
Hour 3 | 0006 | 0 | V | 16 | 0.3 | 7.7 | 4.3 | 61 | 5.7 | 80 | 181 | 282 | 3.9 | 0.5 | 0.2 | 72 | 218 |
Hour 6 | 0025 | 0 | V | 12 | 0.4 | 5.9 | 3.0 | 36 | 2 | 83 | 321 | 260 | 4.3 | 0.2 | 0.1 | 59 | 92 |
Hour 6 | 0026 | 0 | V | 10 | 0.5 | 6.5 | 2.9 | 39 | 3 | 79 | 350 | 237 | 7.2 | 0.3 | 0.1 | 66 | 186 |
Hour 6 | 0027 | 0 | V | 10 | 0.4 | 6.1 | 2.8 | 33 | 9.5 | 67 | 146 | 225 | 6.1 | 0.3 | 0.1 | 66 | 148 |
Hour 6 | 0028 | 0 | V | 9 | 0.4 | 6.1 | 3.0 | 34 | 9.2 | 78 | 152 | 238 | 6.0 | 0.3 | 0.1 | 63 | 139 |
Hour 6 | 0029 | 0 | V | 10 | 0.4 | 5.9 | 3.2 | 36 | 5.7 | 70 | 189 | 277 | 5.3 | 0.3 | 0.1 | 61 | 177 |
Hour 6 | 0030 | 0 | V | 11 | 0.5 | 6.2 | 3.2 | 48 | 0.5 | 155 | 476 | 277 | 4.9 | 0.5 | 0.2 | 62 | 2.6 |
Hour 24 | 0049 | 0 | V | 12 | 0.2 | 6.2 | 3.3 | 38 | 3.7 | 67 | 583 | 260 | 7.0 | 0.8 | 0.4 | 57 | 228 |
Hour 24 | 0050 | 0 | V | 12 | 0.3 | 6.7 | 3.2 | 45 | 3.9 | 93 | 796 | 3.5 | 5.7 | 0.8 | 0.4 | 59 | 228 |
Hour 24 | 0051 | 0 | V | 12 | 0.3 | 6.5 | 3.2 | 44 | 3.4 | 66 | 432 | 286 | 7.3 | 1.0 | 0.5 | 54 | 238 |
Hour 24 | 0052 | 0 | V | 13 | 0.3 | 6.4 | 3.3 | 43 | 3.0 | 71 | 463 | 330 | 5.5 | 0.9 | 0.4 | 59 | 196 |
Hour 24 | 0053 | 0 | V | 14 | 0.3 | 6.4 | 3.2 | 43 | 10.7 | 67 | 333 | 349 | 7.0 | 0.6 | 0.3 | 66 | 176 |
Hour 24 | 0054 | 0 | V | 13 | 0.3 | 6.5 | 3.3 | 47 | 12.5 | 71 | 339 | 281 | 5.3 | 0.5 | 0.2 | 67 | 162 |
Hour 3 | 0007 | 0.5 | 17 | 0.4 | 7.0 | 3.0 | 48 | 3.6 | 80 | 222 | 319 | 6.5 | 0.2 | 0.1 | 63 | 80 | |
Hour 3 | 0008 | 0.5 | 14 | 0.3 | 6.9 | 3.3 | 46 | 1.7 | 85 | 215 | 296 | 3.4 | 0.3 | 0.1 | 67 | 140 | |
Hour 3 | 0009 | 0.5 | 14 | 0.3 | 7.6 | 3.3 | 53 | 5.7 | 83 | 255 | 326 | 4.2 | 0.5 | 0.2 | 69 | 168 | |
Hour 3 | 0010 | 0.5 | 14 | 0.3 | 7.4 | 3.6 | 48 | 5.7 | 95 | 217 | 335 | 7.6 | 0.3 | 0.1 | 64 | 101 | |
Hour 3 | 0011 | 0.5 | 14 | 0.3 | 7.0 | 4.3 | 39 | 0.7 | 86 | 206 | 304 | 4.7 | 0.4 | 0.2 | 59 | 164 | |
Hour 3 | 0012 | 0.5 | 14 | 0.3 | 7.3 | 2.8 | 43 | 5.6 | 72 | 221 | 288 | 4.0 | 0.4 | 0.1 | 59 | 181 | |
Hour 6 | 0031 | 0.5 | 11 | 0.6 | 8.3 | 3.0 | 44 | 7.4 | 72 | 227 | 337 | 4.9 | 0.3 | 0.1 | 65 | 212 | |
Hour 6 | 0032 | 0.5 | 13 | 0.4 | 6.6 | 2.7 | 40 | 5.8 | 74 | 274 | 281 | 4.6 | 0.4 | 0.1 | 71 | 222 | |
Hour 6 | 0033 | 0.5 | 10 | 0.5 | 6.4 | 3.0 | 36 | 8.8 | 74 | 223 | 282 | 5.2 | 0.5 | 0.1 | 65 | 204 | |
Hour 6 | 0034 | 0.5 | 9 | 0.4 | 5.7 | 3.3 | 33 | 0.6 | 77 | 472 | 281 | 3.8 | 0.3 | 0.1 | 63 | 113 | |
Hour 6 | 0035 | 0.5 | 11 | 0.4 | 6.0 | 3.5 | 42 | 7.4 | 69 | 210 | 280 | 5.6 | 0.3 | 0.1 | 68 | 254 | |
Hour 6 | 0036 | 0.5 | 13 | 0.4 | 6.0 | 3.4 | 43 | 9.5 | 84 | 175 | 325 | 7.1 | 0.3 | 0.1 | 69 | 242 | |
Hour 24 | 0055 | 0.5 | 13 | 0.2 | 6.8 | 2.7 | 43 | 4.2 | 71 | 462 | 270 | 6.1 | 0.6 | 0.3 | 66 | 166 | |
Hour 24 | 0056 | 0.5 | 14 | 0.3 | 7.0 | 3.5 | 45 | 3.7 | 73 | 753 | 265 | 6.0 | 0.7 | 0.3 | 71 | 187 | |
Hour 24 | 0057 | 0.5 | 16 | 0.4 | 6.7 | 3.4 | 54 | 4.3 | 88 | 461 | 322 | 6.9 | 0.6 | 0.2 | 64 | 143 | |
Hour 24 | 0058 | 0.5 | 13 | 0.3 | 6.9 | 3.8 | 49 | 3.0 | 94 | 523 | 277 | 6.1 | 0.5 | 0.3 | 63 | 150 | |
Hour 24 | 0059 | 0.5 | 12 | 0.4 | 6.1 | 3.1 | 46 | 4.3 | 70 | 321 | 335 | 6.7 | 0.5 | 0.2 | 53 | 135 | |
Hour 24 | 0060 | 0.5 | 12 | 0.3 | 6.0 | 3.2 | 42 | 5.9 | 72 | 326 | 275 | 7.1 | 0.4 | 0.1 | 58 | 95 | |
Hour 3 | 0013 | 1 | 14 | 0.3 | 7.5 | 2.8 | 47 | 6.1 | 70 | 178 | 250 | 4.8 | 0.3 | 0.1 | 65 | 134 | |
Hour 3 | 0014 | 1 | 13 | 0.3 | 7.8 | 2.7 | 49 | 4.3 | 84 | 309 | 268 | 3.6 | 0.4 | 0.2 | 63 | 128 | |
Hour 3 | 0015 | 1 | 13 | 0.3 | 7.5 | 2.7 | 36 | qns | 59 | 136 | 253 | 3.8 | 0.3 | 0.1 | 64 | 107 | |
Hour 3 | 0016 | 1 | 12 | 0.3 | 7.7 | 2.8 | 49 | 1.8 | 81 | 208 | 298 | 5.2 | 0.2 | 0.1 | 64 | 87 | |
Hour 3 | 0017 | 1 | 11 | 0.2 | 7.3 | 2.8 | 39 | 0.5 | 70 | 129 | 343 | 8.4 | 0.2 | 0.1 | 61 | 110 | |
Hour 3 | 0018 | 1 | 11 | 0.4 | 7.4 | 2.7 | 37 | 1.2 | 63 | 154 | 251 | 3.9 | 0.2 | 0.1 | 61 | 100 | |
Hour 6 | 0037 | 1 | 9 | 0.4 | 6.3 | 3.6 | 37 | 9.1 | 76 | 279 | 260 | 4.0 | 0.4 | 0.1 | 61 | 261 | |
Hour 6 | 0038 | 1 | 13 | 0.4 | 6.4 | 3.5 | 47 | 10.8 | 70 | 260 | 258 | 4.8 | 0.4 | 0.1 | 71 | 320 | |
Hour 6 | 0039 | 1 | 8 | 0.3 | 6.1 | 3.1 | 47 | 6.5 | 94 | 249 | 301 | 4.4 | 0.2 | 0.1 | 65 | 185 | |
Hour 6 | 0040 | 1 | 10 | 0.4 | 5.7 | 2.9 | 37 | 5.5 | 78 | 251 | 333 | 4.4 | 0.3 | 0.1 | 57 | 210 | |
Hour 6 | 0041 | 1 | 9 | 0.4 | 6.1 | 3.2 | 32 | 5.4 | 74 | 167 | 254 | 3.8 | 0.2 | <0.1 | 69 | 168 | |
Hour 6 | 0042 | 1 | 9 | 0.4 | 6.4 | 3.4 | 33 | 8.4 | 70 | 183 | 274 | 4.6 | 0.2 | 0.1 | 63 | 139 | |
Hour 24 | 0061 | 1 | 14 | 0.4 | 7.0 | 3.6 | 57 | 3.3 | 69 | 583 | 301 | 6.2 | 0.8 | 0.4 | 67 | 199 | |
Hour 24 | 0062 | 1 | 14 | 0.3 | 7.8 | 3.4 | 39 | 9.2 | 72 | 620 | 290 | 5.8 | 0.8 | 0.4 | 66 | 166 | |
Hour 24 | 0063 | 1 | 13 | 0.3 | 7.0 | 3.6 | 32 | 5.7 | 57 | 440 | 318 | 7.1 | 0.6 | 0.3 | 55 | 154 | |
Hour 24 | 0064 | 1 | 12 | 0.3 | 7.4 | 3.6 | 46 | 2.2 | 70 | 496 | 289 | 9.8 | 0.6 | 0.3 | 60 | 210 | |
Hour 24 | 0065 | 1 | 13 | 0.3 | 6.2 | 3.1 | 46 | 2.4 | 92 | 519 | 296 | 10.6 | 0.4 | 0.2 | 67 | 162 | |
Hour 24 | 0066 | 1 | 12 | 0.3 | 7.0 | 3.1 | 45 | qns | 69 | 460 | 285 | 5.7 | 0.4 | 0.1 | 67 | 200 | |
Hour 3 | 0019 | 5 | 13 | 0.2 | 6.6 | 2.7 | 40 | 2.7 | 67 | 228 | 277 | 6.4 | 0.4 | 0.2 | 62 | 162 | |
Hour 3 | 0020 | 5 | 15 | 0.3 | 6.5 | 2.8 | 42 | 4.8 | 79 | 187 | 305 | 9.7 | 0.3 | 0.1 | 57 | 149 | |
Hour 3 | 0021 | 5 | 13 | 0.3 | 6.3 | 2.6 | 45 | qns | 80 | 336 | 291 | 6.2 | 0.3 | 0.1 | 64 | 110 | |
Hour 3 | 0022 | 5 | 13 | 0.3 | 6.8 | 2.7 | 51 | 2.2 | 101 | 211 | 271 | 7.1 | 0.3 | 0.1 | 63 | 85 | |
Hour 3 | 0023 | 5 | 11 | 0.3 | 6.7 | 2.7 | 37 | qns | 76 | 165 | 272 | 4.9 | 0.3 | 0.1 | 59 | 129 | |
Hour 3 | 0024 | 5 | 12 | 0.3 | 6.4 | 3.1 | 44 | 8.4 | 63 | 128 | 312 | 10.1 | 0.3 | 0.1 | 57 | 129 | |
Hour 6 | 0043 | 5 | 9 | 0.4 | 7.1 | 3.7 | 42 | 6.1 | 87 | 173 | 312 | 6.6 | 0.2 | 0.1 | 66 | 162 | |
Hour 6 | 0044 | 5 | 11 | 0.4 | 7.1 | 3.3 | 41 | 8.0 | 67 | 195 | 281 | 6.4 | 0.3 | 0.1 | 68 | 207 | |
Hour 6 | 0045 | 5 | 12 | 0.4 | 7.9 | 3.9 | 37 | 3.9 | 73 | 341 | 286 | 5.4 | 0.4 | 0.1 | 69 | 334 | |
Hour 6 | 0046 | 5 | 11 | 0.3 | 7.4 | 3.1 | 34 | 6.4 | 56 | 237 | 295 | 5.8 | 0.2 | 0.1 | 59 | 193 | |
Hour 6 | 0047 | 5 | 10 | 0.8 | 9.9 | 4.2 | 51 | 1.1 | 112 | 800 | 282 | 5.5 | 1.4 | 0.4 | 61 | 343 | |
Hour 6 | 0048 | 5 | 13 | 0.4 | 8.5 | 4.2 | 39 | 7.3 | 85 | 236 | 298 | 5.3 | 0.3 | 0.1 | 59 | 319 | |
Hour 24 | 0067 | 5 | 13 | 0.3 | 8.4 | 3.2 | 26 | qns | 57 | 769 | 309 | 6.9 | 0.7 | 0.3 | 65 | 316 | |
Hour 24 | 0068 | 5 | 15 | 0.4 | 8.5 | 2.8 | 39 | qns | 67 | 715 | 316 | 6.9 | 0.7 | 0.3 | 66 | 324 | |
Hour 24 | 0069 | 5 | 13 | 0.5 | 8.5 | 3.2 | 36 | qns | 68 | 798 | 291 | 9.0 | 0.9 | 0.3 | 68 | 373 | |
Hour 24 | 0070 | 5 | 12 | 0.6 | 8.8 | 2.8 | 45 | 1.0 | 65 | 519 | 285 | 4.4 | 0.8 | 0.3 | 69 | 331 | |
Hour 24 | 0071 | 5 | 12 | 0.3 | 8.5 | 3.7 | 27 | 4.8 | 43 | 325 | 282 | 4.8 | 0.5 | 0.2 | 69 | 325 | |
Hour 24 | 0072 | 5 | 13 | 0.4 | 8.5 | 3.6 | 52 | 4.8 | 76 | 310 | 282 | 3.7 | 0.5 | 0.2 | 71 | 363 | |
Abbreviations: | |||||||||||||||||
NA: Not Available, V: Vehicle Control, BUN: Urea Nitrogen, Creat: Creatinine, TP: Protein Total, ALB: Albumin, ALT: Alanine Aminotransferase, SDH: Sorbitol Dehydrogenase, AST: Aspartate Aminotransferase, LDH: Lactate Dehydrogenase, ALP: Alkaline Phosphatase, TBA: Bile Acids Per G Tissue, Tot Bilirubin: Bilirubin Total, Dir Bilirubin: Bilirubin Direct, Triglyceride: Triglycerides |