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Chemical Name: | Sodium Cyanide |
---|---|
CASRN: | ="143-33-9" |
Study Number: | C62124B |
Study Length (Year Completed): | 13 Weeks (N/A) |
Exposure Route: | WATER |
TDMS Number: | 0515906.ss |
Sex: | Male |
Strain and Species: | B6C3F1 Mice |
Clinical Chemistry Individual Animal Data | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Measurement Time | Animal Number | Dose Group (ppm) | Control Code | BUN (mg_dL) | Creat (U per L) | TP (g_dL) | ALB (g_dL) | Creat Kinase (IU_L) | ALT (IU_L) | SDH (IU_L) | ALP (IU_L) | 5'Nuc (IU_L) |
Week 13 | 0001 | 0 | U | 26.6 | 0.36 | 6.2 | 3.4 | 764 | 123 | 36 | 79 | |
Week 13 | 0002 | 0 | U | 31.7 | 5.6 | 3.1 | 246 | 47 | 38 | 64 | ||
Week 13 | 0003 | 0 | U | 28.2 | 265 | 67 | ||||||
Week 13 | 0004 | 0 | U | 34.8 | 0.47 | 5.9 | 3.3 | 116 | 33 | 36 | 72 | 30 |
Week 13 | 0005 | 0 | U | 36.6 | 0.4 | 5.4 | 3.1 | 179 | 30 | 40 | 71 | |
Week 13 | 0006 | 0 | U | 25.5 | 5.6 | 158 | 51 | 29 | 63 | |||
Week 13 | 0007 | 0 | U | 29.2 | 0.42 | 6.4 | 3.4 | 270 | 38 | 38 | 72 | 33 |
Week 13 | 0008 | 0 | U | 22 | 0.34 | 6.7 | 3.8 | 407 | 35 | 41 | 70 | |
Week 13 | 0009 | 0 | U | 29.1 | 0.38 | 5.9 | 3.4 | 655 | 132 | 43 | 71 | 56 |
Week 13 | 0010 | 0 | U | 33.8 | 3.2 | 152 | 76 | |||||
Week 13 | 0011 | 3 | 32.2 | 6 | 3.2 | 62 | 28 | 35 | 71 | |||
Week 13 | 0012 | 3 | 28.8 | 113 | 33 | 58 | ||||||
Week 13 | 0013 | 3 | 31 | 0.45 | 5.8 | 3.2 | 375 | 26 | 37 | 73 | ||
Week 13 | 0014 | 3 | 30.4 | 0.36 | 5.4 | 3.2 | 107 | 28 | 34 | 70 | 32 | |
Week 13 | 0015 | 3 | 30.3 | 0.34 | 5.6 | 3 | 198 | 32 | 33 | 65 | 31 | |
Week 13 | 0016 | 3 | 32.1 | 5.7 | 355 | 38 | 35 | 61 | ||||
Week 13 | 0017 | 3 | 33.5 | 0.36 | 6.1 | 3.8 | 282 | 30 | 56 | 71 | 39 | |
Week 13 | 0018 | 3 | 26.3 | 0.31 | 5.4 | 2.9 | 289 | 56 | 43 | 70 | ||
Week 13 | 0019 | 3 | 30.1 | 347 | 31 | 45 | 81 | 42 | ||||
Week 13 | 0020 | 3 | 28.6 | 0.33 | 5.5 | 3.1 | 83 | 27 | 38 | 65 | 32 | |
Week 13 | 0021 | 10 | 28.7 | 0.33 | 5.7 | 286 | 69 | 33 | 67 | |||
Week 13 | 0022 | 10 | 28.1 | 6 | 3.2 | 653 | 31 | 36 | 71 | |||
Week 13 | 0023 | 10 | 1347 | 96 | 37 | 73 | ||||||
Week 13 | 0024 | 10 | 28.9 | 0.34 | 5.9 | 896 | 54 | 46 | 79 | |||
Week 13 | 0025 | 10 | 31.2 | 0.35 | 5.7 | 3.2 | 223 | 25 | 35 | 64 | 39 | |
Week 13 | 0026 | 10 | 29.9 | 601 | 42 | 58 | ||||||
Week 13 | 0027 | 10 | 32.2 | 6 | 3.4 | 607 | 35 | 34 | 72 | |||
Week 13 | 0028 | 10 | 33.4 | 697 | 366* | 77 | ||||||
Week 13 | 0029 | 10 | 37.5 | 3 | 200 | 29 | 70 | |||||
Week 13 | 0030 | 10 | 35.5 | 5.8 | 888 | 65 | ||||||
Week 13 | 0031 | 30 | 63 | 60 | ||||||||
Week 13 | 0032 | 30 | 31.2 | 416 | 50 | 46 | 71 | |||||
Week 13 | 0033 | 30 | 33 | 0.45 | 6 | 3.3 | 202 | 26 | 38 | 63 | 39 | |
Week 13 | 0034 | 30 | 258 | |||||||||
Week 13 | 0035 | 30 | 26.2 | 0.35 | 6 | 3.4 | 101 | 31 | 31 | 64 | 33 | |
Week 13 | 0036 | 30 | 28.2 | 0.4 | 5.9 | 3.3 | 393 | 34 | 37 | 77 | 34 | |
Week 13 | 0037 | 30 | 27.5 | 0.43 | 5.6 | 2.9 | 648 | 55 | 39 | 67 | 34 | |
Week 13 | 0038 | 30 | 28 | 0.31 | 5.8 | 2.9 | 182 | 38 | 40 | 71 | ||
Week 13 | 0039 | 30 | 29.5 | 5.8 | 385 | 36 | 46 | 67 | ||||
Week 13 | 0040 | 30 | 29.2 | 0.45 | 5.8 | 752 | 79 | 37 | 76 | 45 | ||
Week 13 | 0041 | 100 | 32.6 | 0.33 | 5.9 | 3.2 | 278 | 32 | 36 | 63 | 40 | |
Week 13 | 0042 | 100 | 29.8 | 0.36 | 6 | 3.2 | 207 | 27 | 35 | 71 | 31 | |
Week 13 | 0043 | 100 | 27.4 | 5.5 | 3 | 64 | 42 | 32 | 70 | |||
Week 13 | 0044 | 100 | 26.6 | 6.2 | 3.4 | 384 | 193* | 46 | 84 | |||
Week 13 | 0045 | 100 | 29.5 | 0.41 | 5.8 | 3.2 | 522 | 37 | 39 | 69 | ||
Week 13 | 0046 | 100 | 32.5 | 6 | 3.2 | 299 | 36 | 35 | 68 | |||
Week 13 | 0047 | 100 | 34.6 | 0.46 | 5.9 | 3.1 | 315 | 31 | 36 | 74 | 35 | |
Week 13 | 0048 | 100 | 33.2 | 0.38 | 5.6 | 3 | 208 | 31 | 35 | 68 | 28 | |
Week 13 | 0049 | 100 | 31 | 0.34 | 6.1 | 3.5 | 351 | 37 | 43 | 79 | 31 | |
Week 13 | 0050 | 100 | 29.3 | 5.8 | 3.3 | 410 | 69 | |||||
Week 13 | 0051 | 300 | 25.3 | 5.9 | 3.1 | 1284 | 74 | 54 | 76 | |||
Week 13 | 0052 | 300 | 26.4 | 0.3 | 5.6 | 3 | 163 | 30 | 42 | 63 | ||
Week 13 | 0053 | 300 | 26.6 | 0.43 | 6 | 3.2 | 207 | 42 | 39 | 72 | 31 | |
Week 13 | 0054 | 300 | 29.4 | 6.2 | 3.4 | 1170 | 102 | 34 | 78 | |||
Week 13 | 0055 | 300 | 29 | 0.26 | 5.8 | 3.4 | 165 | 26 | 44 | 76 | 37 | |
Week 13 | 0056 | 300 | 30 | 0.34 | 5.8 | 230 | 25 | 52 | 72 | 42 | ||
Week 13 | 0057 | 300 | 21.6 | 0.23 | 6.7 | 3.7 | 342 | 24 | 36 | 70 | 33 | |
Week 13 | 0058 | 300 | 22.8 | 0.35 | 5.9 | 142 | 38 | 39 | 71 | |||
Week 13 | 0059 | 300 | 30.3 | 0.44 | 5.6 | 3.3 | 325 | 41 | 45 | 75 | 59 | |
Week 13 | 0060 | 300 | 31 | 0.44 | 5.9 | 3.3 | 930 | 137 | 45 | 80 | ||
Abbreviations: | ||||||||||||
NA: Not Available, U: Untreated Control, BUN: Urea Nitrogen, Creat: Creatinine, TP: Protein Total, ALB: Albumin, Creat Kinase: Creatine Kinase, ALT: Alanine Aminotransferase, SDH: Sorbitol Dehydrogenase, ALP: Alkaline Phosphatase, 5'Nuc: 5 Prime Nucleotidase |