If this is the first time you are viewing this file, please choose 'Save As' from the 'File' menu
and resave this file as an Excel file type. This will greatly speed up future viewings of this file.
Short-Term Individual Animal Non Neoplastic Diagnosis
Study Information:
Chemical Name: | Tetrabromobisphenol A |
CASRN: | ="79-94-7" |
Study Number: | C20320 |
Exposure Route: | GAVAGE |
TDMS Number: | 2032002 |
Sex: | Male |
Strain and Species: | B6C3F1/N Mice |
Male Individual Animal Non Neoplastic Diagnoses
System |
Organ |
Site |
Treatment Group |
Number Examined |
Cage Number |
Animal Number |
Days on Study |
Lesion Found |
Lesion Name |
Lesion Qualifier |
Removal Reason |
Alimentary System |
Liver |
|
100 mg/kg |
10 |
337 |
337 |
93 |
1 |
Fatty Change |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
10 |
352 |
352 |
93 |
1 |
Tension Lipidosis |
Minimal |
Terminal Sacrifice |
Alimentary System |
Pancreas |
|
Vehicle Control |
10 |
305 |
305 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Urinary System |
Kidney |
Cortex |
50 mg/kg |
10 |
325 |
325 |
93 |
1 |
Regeneration |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
Pelvis |
Vehicle Control |
10 |
303 |
303 |
93 |
1 |
Dilatation |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
Pelvis |
10 mg/kg |
10 |
313 |
313 |
93 |
1 |
Dilatation |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
Pelvis |
50 mg/kg |
10 |
327 |
327 |
93 |
1 |
Dilatation |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
500 mg/kg |
10 |
341 |
341 |
93 |
1 |
Cytoplasmic Alteration |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
500 mg/kg |
10 |
342 |
342 |
93 |
1 |
Cytoplasmic Alteration |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
500 mg/kg |
10 |
343 |
343 |
93 |
1 |
Cytoplasmic Alteration |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
500 mg/kg |
10 |
344 |
344 |
93 |
1 |
Cytoplasmic Alteration |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
500 mg/kg |
10 |
345 |
345 |
93 |
1 |
Cytoplasmic Alteration |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
500 mg/kg |
10 |
346 |
346 |
93 |
1 |
Cytoplasmic Alteration |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
500 mg/kg |
10 |
347 |
347 |
93 |
1 |
Cytoplasmic Alteration |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
500 mg/kg |
10 |
348 |
348 |
93 |
1 |
Cytoplasmic Alteration |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
500 mg/kg |
10 |
349 |
349 |
93 |
1 |
Cytoplasmic Alteration |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
500 mg/kg |
10 |
350 |
350 |
93 |
1 |
Cytoplasmic Alteration |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
1000 mg/kg |
10 |
351 |
351 |
93 |
1 |
Cytoplasmic Alteration |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
1000 mg/kg |
10 |
352 |
352 |
93 |
1 |
Cytoplasmic Alteration |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
1000 mg/kg |
10 |
353 |
353 |
93 |
1 |
Cytoplasmic Alteration |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
1000 mg/kg |
10 |
354 |
354 |
93 |
1 |
Cytoplasmic Alteration |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
1000 mg/kg |
10 |
355 |
355 |
93 |
1 |
Cytoplasmic Alteration |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
1000 mg/kg |
10 |
356 |
356 |
93 |
1 |
Cytoplasmic Alteration |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
1000 mg/kg |
10 |
357 |
357 |
93 |
1 |
Cytoplasmic Alteration |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
1000 mg/kg |
10 |
358 |
358 |
93 |
1 |
Cytoplasmic Alteration |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
1000 mg/kg |
10 |
359 |
359 |
93 |
1 |
Cytoplasmic Alteration |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
1000 mg/kg |
10 |
360 |
360 |
93 |
1 |
Cytoplasmic Alteration |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
Vehicle Control |
10 |
302 |
302 |
93 |
1 |
Regeneration |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
100 mg/kg |
10 |
331 |
331 |
93 |
1 |
Regeneration |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
100 mg/kg |
10 |
338 |
338 |
93 |
1 |
Regeneration |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
500 mg/kg |
10 |
341 |
341 |
93 |
1 |
Regeneration |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
1000 mg/kg |
10 |
358 |
358 |
93 |
1 |
Regeneration |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
306 |
306 |
93 |
1 |
Casts Protein |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
100 mg/kg |
10 |
338 |
338 |
93 |
1 |
Casts Protein |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
500 mg/kg |
10 |
341 |
341 |
93 |
1 |
Casts Protein |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
1000 mg/kg |
10 |
352 |
352 |
93 |
1 |
Casts Protein |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
1000 mg/kg |
10 |
360 |
360 |
93 |
1 |
Casts Protein |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
1000 mg/kg |
10 |
352 |
352 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Urinary System |
Urinary Bladder |
|
Vehicle Control |
10 |
305 |
305 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |