Alimentary System |
Esophagus |
|
1000 mg/kg |
50 |
177 |
177 |
451 |
1 |
Inflammation |
Moderate |
Dosing Accident |
Alimentary System |
Gallbladder |
|
Vehicle Control |
50 |
21 |
21 |
732 |
1 |
Pigmentation |
Moderate, Hematoidin |
Terminal Sacrifice |
Alimentary System |
Intestine Large |
Colon |
500 mg/kg |
50 |
106 |
106 |
513 |
1 |
Diverticulum |
Marked |
Natural Death |
Alimentary System |
Intestine Large |
Colon |
250 mg/kg |
50 |
83 |
83 |
730 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Alimentary System |
Intestine Small |
Ileum |
Vehicle Control |
50 |
31 |
31 |
730 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Intestine Small |
Jejunum |
250 mg/kg |
50 |
75 |
75 |
708 |
1 |
Diverticulum |
Mild |
Moribund Sacrifice |
Alimentary System |
Intestine Small |
Jejunum, Peyers Patch |
500 mg/kg |
50 |
117 |
117 |
731 |
1 |
Hyperplasia |
Mild, Lymphoid |
Terminal Sacrifice |
Alimentary System |
Intestine Small |
Jejunum, Peyers Patch |
1000 mg/kg |
50 |
161 |
161 |
731 |
1 |
Hyperplasia |
Mild, Lymphoid |
Terminal Sacrifice |
Alimentary System |
Liver |
Bile Duct |
500 mg/kg |
50 |
107 |
107 |
731 |
1 |
Cyst |
|
Terminal Sacrifice |
Alimentary System |
Liver |
Bile Duct |
500 mg/kg |
50 |
129 |
129 |
732 |
1 |
Cyst |
|
Terminal Sacrifice |
Alimentary System |
Liver |
Bile Duct |
500 mg/kg |
50 |
134 |
134 |
732 |
1 |
Cyst |
|
Terminal Sacrifice |
Alimentary System |
Liver |
Bile Duct |
1000 mg/kg |
50 |
157 |
157 |
511 |
1 |
Cyst |
|
Moribund Sacrifice |
Alimentary System |
Liver |
Bile Duct |
1000 mg/kg |
50 |
167 |
167 |
688 |
1 |
Cyst |
|
Moribund Sacrifice |
Alimentary System |
Liver |
Bile Duct |
1000 mg/kg |
50 |
154 |
154 |
686 |
1 |
Cyst |
|
Natural Death |
Alimentary System |
Liver |
Bile Duct |
1000 mg/kg |
50 |
166 |
166 |
730 |
Multiple |
Cyst |
|
Terminal Sacrifice |
Alimentary System |
Liver |
Bile Duct |
1000 mg/kg |
50 |
172 |
172 |
730 |
1 |
Cyst |
|
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
250 mg/kg |
50 |
87 |
87 |
673 |
1 |
Atrophy |
Mild |
Natural Death |
Alimentary System |
Liver |
Hepatocyte |
Vehicle Control |
50 |
43 |
43 |
661 |
1 |
Hypertrophy |
Minimal |
Natural Death |
Alimentary System |
Liver |
Hepatocyte |
Vehicle Control |
50 |
21 |
21 |
732 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
250 mg/kg |
50 |
81 |
81 |
700 |
1 |
Necrosis |
Minimal |
Moribund Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
250 mg/kg |
50 |
68 |
68 |
732 |
1 |
Necrosis |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
500 mg/kg |
50 |
111 |
111 |
577 |
1 |
Necrosis |
Mild |
Natural Death |
Alimentary System |
Liver |
Kupffer Cell |
500 mg/kg |
50 |
115 |
115 |
730 |
1 |
Pigmentation |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Kupffer Cell |
500 mg/kg |
50 |
118 |
118 |
731 |
1 |
Pigmentation |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Oval Cell |
500 mg/kg |
50 |
115 |
115 |
730 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Periportal |
500 mg/kg |
50 |
128 |
128 |
540 |
1 |
Vacuolization Cytoplasmic |
Moderate |
Moribund Sacrifice |
Alimentary System |
Liver |
Periportal |
1000 mg/kg |
50 |
195 |
195 |
408 |
1 |
Vacuolization Cytoplasmic |
Mild |
Natural Death |
Alimentary System |
Liver |
Periportal |
1000 mg/kg |
50 |
198 |
198 |
340 |
1 |
Vacuolization Cytoplasmic |
Mild |
Natural Death |
Alimentary System |
Liver |
Serosa |
500 mg/kg |
50 |
129 |
129 |
732 |
1 |
Inflammation |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
48 |
48 |
640 |
1 |
Amyloid Deposition |
Minimal |
Moribund Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
50 |
199 |
199 |
522 |
1 |
Amyloid Deposition |
Moderate |
Moribund Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
101 |
101 |
731 |
1 |
Angiectasis |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
107 |
107 |
731 |
1 |
Angiectasis |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
50 |
183 |
183 |
731 |
1 |
Angiectasis |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
23 |
23 |
555 |
1 |
Basophilic Focus |
|
Moribund Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
13 |
13 |
683 |
1 |
Basophilic Focus |
|
Natural Death |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
26 |
26 |
640 |
1 |
Basophilic Focus |
|
Natural Death |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
20 |
20 |
732 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
22 |
22 |
732 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
3 |
3 |
730 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
31 |
31 |
730 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
36 |
36 |
730 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
4 |
4 |
732 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
250 mg/kg |
50 |
75 |
75 |
708 |
1 |
Basophilic Focus |
|
Moribund Sacrifice |
Alimentary System |
Liver |
|
250 mg/kg |
50 |
81 |
81 |
700 |
1 |
Basophilic Focus |
|
Moribund Sacrifice |
Alimentary System |
Liver |
|
250 mg/kg |
50 |
59 |
59 |
403 |
1 |
Basophilic Focus |
|
Natural Death |
Alimentary System |
Liver |
|
250 mg/kg |
50 |
56 |
56 |
732 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
250 mg/kg |
50 |
63 |
63 |
732 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
250 mg/kg |
50 |
68 |
68 |
732 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
250 mg/kg |
50 |
78 |
78 |
732 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
250 mg/kg |
50 |
84 |
84 |
732 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
250 mg/kg |
50 |
90 |
90 |
732 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
106 |
106 |
513 |
1 |
Basophilic Focus |
|
Natural Death |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
101 |
101 |
731 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
133 |
133 |
730 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
135 |
135 |
732 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
137 |
137 |
731 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
149 |
149 |
732 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
50 |
177 |
177 |
451 |
1 |
Basophilic Focus |
|
Dosing Accident |
Alimentary System |
Liver |
|
1000 mg/kg |
50 |
165 |
165 |
511 |
1 |
Basophilic Focus |
|
Moribund Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
50 |
167 |
167 |
688 |
1 |
Basophilic Focus |
|
Moribund Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
50 |
170 |
170 |
633 |
1 |
Basophilic Focus |
|
Moribund Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
50 |
158 |
158 |
686 |
1 |
Basophilic Focus |
|
Natural Death |
Alimentary System |
Liver |
|
1000 mg/kg |
50 |
163 |
163 |
718 |
1 |
Basophilic Focus |
|
Natural Death |
Alimentary System |
Liver |
|
1000 mg/kg |
50 |
200 |
200 |
704 |
1 |
Basophilic Focus |
|
Natural Death |
Alimentary System |
Liver |
|
1000 mg/kg |
50 |
159 |
159 |
731 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
50 |
161 |
161 |
731 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
10 |
10 |
673 |
1 |
Clear Cell Focus |
|
Natural Death |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
26 |
26 |
640 |
1 |
Clear Cell Focus |
|
Natural Death |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
1 |
1 |
730 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
19 |
19 |
731 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
31 |
31 |
730 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
32 |
32 |
731 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
35 |
35 |
730 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
38 |
38 |
732 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
4 |
4 |
732 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
45 |
45 |
732 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
49 |
49 |
732 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
250 mg/kg |
50 |
88 |
88 |
714 |
1 |
Clear Cell Focus |
|
Moribund Sacrifice |
Alimentary System |
Liver |
|
250 mg/kg |
50 |
58 |
58 |
732 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
250 mg/kg |
50 |
77 |
77 |
732 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
250 mg/kg |
50 |
78 |
78 |
732 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
250 mg/kg |
50 |
82 |
82 |
730 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
250 mg/kg |
50 |
83 |
83 |
730 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
250 mg/kg |
50 |
84 |
84 |
732 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
250 mg/kg |
50 |
86 |
86 |
732 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
250 mg/kg |
50 |
89 |
89 |
732 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
250 mg/kg |
50 |
96 |
96 |
732 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
101 |
101 |
731 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
104 |
104 |
731 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
105 |
105 |
731 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
107 |
107 |
731 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
110 |
110 |
731 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
113 |
113 |
731 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
118 |
118 |
731 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
121 |
121 |
732 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
125 |
125 |
732 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
126 |
126 |
732 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
129 |
129 |
732 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
130 |
130 |
731 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
131 |
131 |
732 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
133 |
133 |
730 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
134 |
134 |
732 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
135 |
135 |
732 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
137 |
137 |
731 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
138 |
138 |
731 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
139 |
139 |
732 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
140 |
140 |
732 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
141 |
141 |
731 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
142 |
142 |
731 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
144 |
144 |
732 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
146 |
146 |
730 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
149 |
149 |
732 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
50 |
154 |
154 |
686 |
1 |
Clear Cell Focus |
|
Natural Death |
Alimentary System |
Liver |
|
1000 mg/kg |
50 |
173 |
173 |
411 |
1 |
Clear Cell Focus |
|
Natural Death |
Alimentary System |
Liver |
|
1000 mg/kg |
50 |
194 |
194 |
424 |
1 |
Clear Cell Focus |
|
Natural Death |
Alimentary System |
Liver |
|
1000 mg/kg |
50 |
200 |
200 |
704 |
1 |
Clear Cell Focus |
|
Natural Death |
Alimentary System |
Liver |
|
1000 mg/kg |
50 |
153 |
153 |
732 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
50 |
172 |
172 |
730 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
50 |
176 |
176 |
730 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
50 |
183 |
183 |
731 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
15 |
15 |
644 |
1 |
Eosinophilic Focus |
|
Moribund Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
18 |
18 |
714 |
1 |
Eosinophilic Focus |
|
Moribund Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
24 |
24 |
595 |
1 |
Eosinophilic Focus |
|
Moribund Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
16 |
16 |
631 |
1 |
Eosinophilic Focus |
|
Natural Death |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
42 |
42 |
619 |
1 |
Eosinophilic Focus |
|
Natural Death |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
1 |
1 |
730 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
17 |
17 |
731 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
19 |
19 |
731 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
2 |
2 |
731 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
20 |
20 |
732 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
29 |
29 |
731 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
33 |
33 |
731 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
35 |
35 |
730 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
36 |
36 |
730 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
37 |
37 |
732 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
45 |
45 |
732 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
46 |
46 |
730 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
49 |
49 |
732 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
5 |
5 |
731 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
7 |
7 |
732 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
250 mg/kg |
50 |
57 |
57 |
665 |
1 |
Eosinophilic Focus |
|
Moribund Sacrifice |
Alimentary System |
Liver |
|
250 mg/kg |
50 |
65 |
65 |
693 |
1 |
Eosinophilic Focus |
|
Moribund Sacrifice |
Alimentary System |
Liver |
|
250 mg/kg |
50 |
70 |
70 |
613 |
1 |
Eosinophilic Focus |
|
Moribund Sacrifice |
Alimentary System |
Liver |
|
250 mg/kg |
50 |
73 |
73 |
697 |
1 |
Eosinophilic Focus |
|
Moribund Sacrifice |
Alimentary System |
Liver |
|
250 mg/kg |
50 |
75 |
75 |
708 |
1 |
Eosinophilic Focus |
|
Moribund Sacrifice |
Alimentary System |
Liver |
|
250 mg/kg |
50 |
81 |
81 |
700 |
1 |
Eosinophilic Focus |
|
Moribund Sacrifice |
Alimentary System |
Liver |
|
250 mg/kg |
50 |
88 |
88 |
714 |
1 |
Eosinophilic Focus |
|
Moribund Sacrifice |
Alimentary System |
Liver |
|
250 mg/kg |
50 |
94 |
94 |
687 |
1 |
Eosinophilic Focus |
|
Moribund Sacrifice |
Alimentary System |
Liver |
|
250 mg/kg |
50 |
54 |
54 |
526 |
1 |
Eosinophilic Focus |
|
Natural Death |
Alimentary System |
Liver |
|
250 mg/kg |
50 |
62 |
62 |
633 |
1 |
Eosinophilic Focus |
|
Natural Death |
Alimentary System |
Liver |
|
250 mg/kg |
50 |
71 |
71 |
589 |
1 |
Eosinophilic Focus |
|
Natural Death |
Alimentary System |
Liver |
|
250 mg/kg |
50 |
76 |
76 |
608 |
1 |
Eosinophilic Focus |
|
Natural Death |
Alimentary System |
Liver |
|
250 mg/kg |
50 |
52 |
52 |
732 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
250 mg/kg |
50 |
53 |
53 |
731 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
250 mg/kg |
50 |
56 |
56 |
732 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
250 mg/kg |
50 |
58 |
58 |
732 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
250 mg/kg |
50 |
61 |
61 |
732 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
250 mg/kg |
50 |
64 |
64 |
730 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
250 mg/kg |
50 |
67 |
67 |
731 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
250 mg/kg |
50 |
68 |
68 |
732 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
250 mg/kg |
50 |
72 |
72 |
731 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
250 mg/kg |
50 |
74 |
74 |
732 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
250 mg/kg |
50 |
77 |
77 |
732 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
250 mg/kg |
50 |
79 |
79 |
731 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
250 mg/kg |
50 |
80 |
80 |
732 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
250 mg/kg |
50 |
82 |
82 |
730 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
250 mg/kg |
50 |
83 |
83 |
730 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
250 mg/kg |
50 |
84 |
84 |
732 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
250 mg/kg |
50 |
86 |
86 |
732 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
250 mg/kg |
50 |
89 |
89 |
732 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
250 mg/kg |
50 |
90 |
90 |
732 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
250 mg/kg |
50 |
91 |
91 |
730 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
250 mg/kg |
50 |
96 |
96 |
732 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
102 |
102 |
568 |
1 |
Eosinophilic Focus |
|
Moribund Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
119 |
119 |
613 |
1 |
Eosinophilic Focus |
|
Moribund Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
123 |
123 |
674 |
1 |
Eosinophilic Focus |
|
Moribund Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
127 |
127 |
714 |
1 |
Eosinophilic Focus |
|
Moribund Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
106 |
106 |
513 |
1 |
Eosinophilic Focus |
|
Natural Death |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
145 |
145 |
522 |
1 |
Eosinophilic Focus |
|
Natural Death |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
101 |
101 |
731 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
103 |
103 |
731 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
105 |
105 |
731 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
108 |
108 |
731 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
109 |
109 |
731 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
110 |
110 |
731 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
112 |
112 |
732 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
113 |
113 |
731 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
115 |
115 |
730 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
117 |
117 |
731 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
118 |
118 |
731 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
120 |
120 |
731 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
121 |
121 |
732 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
122 |
122 |
730 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
125 |
125 |
732 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
129 |
129 |
732 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
130 |
130 |
731 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
132 |
132 |
731 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
133 |
133 |
730 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
134 |
134 |
732 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
135 |
135 |
732 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
136 |
136 |
730 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
137 |
137 |
731 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
138 |
138 |
731 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
139 |
139 |
732 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
140 |
140 |
732 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
141 |
141 |
731 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
142 |
142 |
731 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
143 |
143 |
732 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
144 |
144 |
732 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
146 |
146 |
730 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
148 |
148 |
730 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
149 |
149 |
732 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
150 |
150 |
731 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
50 |
157 |
157 |
511 |
1 |
Eosinophilic Focus |
|
Moribund Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
50 |
167 |
167 |
688 |
1 |
Eosinophilic Focus |
|
Moribund Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
50 |
190 |
190 |
528 |
1 |
Eosinophilic Focus |
|
Moribund Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
50 |
163 |
163 |
718 |
1 |
Eosinophilic Focus |
|
Natural Death |
Alimentary System |
Liver |
|
1000 mg/kg |
50 |
169 |
169 |
537 |
1 |
Eosinophilic Focus |
|
Natural Death |
Alimentary System |
Liver |
|
1000 mg/kg |
50 |
174 |
174 |
543 |
1 |
Eosinophilic Focus |
|
Natural Death |
Alimentary System |
Liver |
|
1000 mg/kg |
50 |
187 |
187 |
704 |
1 |
Eosinophilic Focus |
|
Natural Death |
Alimentary System |
Liver |
|
1000 mg/kg |
50 |
197 |
197 |
547 |
1 |
Eosinophilic Focus |
|
Natural Death |
Alimentary System |
Liver |
|
1000 mg/kg |
50 |
151 |
151 |
731 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
50 |
159 |
159 |
731 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
50 |
161 |
161 |
731 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
50 |
172 |
172 |
730 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
50 |
184 |
184 |
732 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
50 |
186 |
186 |
730 |
1 |
Eosinophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
1 |
1 |
730 |
1 |
Fatty Change |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
250 mg/kg |
50 |
85 |
85 |
426 |
1 |
Fatty Change |
Moderate |
Natural Death |
Alimentary System |
Liver |
|
250 mg/kg |
50 |
53 |
53 |
731 |
1 |
Fatty Change |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
|
250 mg/kg |
50 |
96 |
96 |
732 |
1 |
Fatty Change |
Minimal, Focal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
130 |
130 |
731 |
1 |
Fatty Change |
Mild, Focal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
131 |
131 |
732 |
1 |
Fatty Change |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
143 |
143 |
732 |
1 |
Fatty Change |
Minimal, Focal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
50 |
165 |
165 |
511 |
1 |
Fatty Change |
Minimal, Focal |
Moribund Sacrifice |
Alimentary System |
Liver |
|
250 mg/kg |
50 |
73 |
73 |
697 |
1 |
Fibrosis |
Minimal |
Moribund Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
144 |
144 |
732 |
1 |
Hemorrhage |
Marked, Chronic |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
48 |
48 |
640 |
1 |
Inflammation |
Minimal |
Moribund Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
50 |
158 |
158 |
686 |
1 |
Inflammation |
Mild, Granulomatous |
Natural Death |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
34 |
34 |
645 |
1 |
Mixed Cell Focus |
|
Moribund Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
2 |
2 |
731 |
1 |
Mixed Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
25 |
25 |
731 |
1 |
Mixed Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
37 |
37 |
732 |
1 |
Mixed Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
38 |
38 |
732 |
1 |
Mixed Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
47 |
47 |
730 |
1 |
Mixed Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
5 |
5 |
731 |
1 |
Mixed Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
250 mg/kg |
50 |
88 |
88 |
714 |
1 |
Mixed Cell Focus |
|
Moribund Sacrifice |
Alimentary System |
Liver |
|
250 mg/kg |
50 |
94 |
94 |
687 |
1 |
Mixed Cell Focus |
|
Moribund Sacrifice |
Alimentary System |
Liver |
|
250 mg/kg |
50 |
52 |
52 |
732 |
1 |
Mixed Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
250 mg/kg |
50 |
58 |
58 |
732 |
1 |
Mixed Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
250 mg/kg |
50 |
61 |
61 |
732 |
1 |
Mixed Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
250 mg/kg |
50 |
80 |
80 |
732 |
1 |
Mixed Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
250 mg/kg |
50 |
82 |
82 |
730 |
1 |
Mixed Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
250 mg/kg |
50 |
84 |
84 |
732 |
1 |
Mixed Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
101 |
101 |
731 |
1 |
Mixed Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
105 |
105 |
731 |
1 |
Mixed Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
117 |
117 |
731 |
1 |
Mixed Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
122 |
122 |
730 |
1 |
Mixed Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
130 |
130 |
731 |
1 |
Mixed Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
133 |
133 |
730 |
1 |
Mixed Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
135 |
135 |
732 |
1 |
Mixed Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
137 |
137 |
731 |
1 |
Mixed Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
139 |
139 |
732 |
1 |
Mixed Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
140 |
140 |
732 |
1 |
Mixed Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
142 |
142 |
731 |
1 |
Mixed Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
149 |
149 |
732 |
1 |
Mixed Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
50 |
170 |
170 |
633 |
1 |
Mixed Cell Focus |
|
Moribund Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
50 |
191 |
191 |
667 |
1 |
Mixed Cell Focus |
|
Moribund Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
50 |
154 |
154 |
686 |
1 |
Mixed Cell Focus |
|
Natural Death |
Alimentary System |
Liver |
|
1000 mg/kg |
50 |
163 |
163 |
718 |
1 |
Mixed Cell Focus |
|
Natural Death |
Alimentary System |
Liver |
|
1000 mg/kg |
50 |
162 |
162 |
730 |
1 |
Mixed Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
50 |
184 |
184 |
732 |
1 |
Mixed Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
43 |
43 |
661 |
1 |
Necrosis |
Mild |
Natural Death |
Alimentary System |
Liver |
|
250 mg/kg |
50 |
69 |
69 |
729 |
1 |
Necrosis |
Mild |
Moribund Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
50 |
167 |
167 |
688 |
1 |
Necrosis |
Mild |
Moribund Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
50 |
164 |
164 |
653 |
1 |
Necrosis |
Mild |
Natural Death |
Alimentary System |
Liver |
|
1000 mg/kg |
50 |
169 |
169 |
537 |
1 |
Necrosis |
Moderate |
Natural Death |
Alimentary System |
Liver |
|
1000 mg/kg |
50 |
174 |
174 |
543 |
1 |
Necrosis |
Mild |
Natural Death |
Alimentary System |
Liver |
|
1000 mg/kg |
50 |
182 |
182 |
548 |
1 |
Necrosis |
Mild |
Natural Death |
Alimentary System |
Liver |
|
1000 mg/kg |
50 |
189 |
189 |
661 |
1 |
Necrosis |
Marked |
Natural Death |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
21 |
21 |
732 |
1 |
Pigmentation |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
18 |
18 |
714 |
1 |
Tension Lipidosis |
Minimal |
Moribund Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
34 |
34 |
645 |
1 |
Tension Lipidosis |
Minimal |
Moribund Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
50 |
4 |
4 |
732 |
1 |
Tension Lipidosis |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
128 |
128 |
540 |
1 |
Tension Lipidosis |
Moderate |
Moribund Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
145 |
145 |
522 |
1 |
Tension Lipidosis |
Minimal |
Natural Death |
Alimentary System |
Liver |
|
500 mg/kg |
50 |
107 |
107 |
731 |
1 |
Tension Lipidosis |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
50 |
175 |
175 |
465 |
1 |
Tension Lipidosis |
Minimal |
Natural Death |
Alimentary System |
Liver |
|
1000 mg/kg |
50 |
153 |
153 |
732 |
1 |
Tension Lipidosis |
Minimal |
Terminal Sacrifice |
Alimentary System |
Mesentery |
Fat |
Vehicle Control |
3 |
13 |
13 |
683 |
1 |
Necrosis |
Marked |
Natural Death |
Alimentary System |
Mesentery |
Fat |
Vehicle Control |
3 |
17 |
17 |
731 |
1 |
Necrosis |
Marked |
Terminal Sacrifice |
Alimentary System |
Mesentery |
Fat |
250 mg/kg |
3 |
94 |
94 |
687 |
1 |
Necrosis |
Marked |
Moribund Sacrifice |
Alimentary System |
Mesentery |
Fat |
250 mg/kg |
3 |
55 |
55 |
664 |
1 |
Necrosis |
Marked |
Natural Death |
Alimentary System |
Mesentery |
Fat |
500 mg/kg |
4 |
109 |
109 |
731 |
1 |
Necrosis |
Marked |
Terminal Sacrifice |
Alimentary System |
Mesentery |
Fat |
500 mg/kg |
4 |
138 |
138 |
731 |
1 |
Necrosis |
Marked |
Terminal Sacrifice |
Alimentary System |
Mesentery |
Fat |
1000 mg/kg |
2 |
200 |
200 |
704 |
1 |
Necrosis |
Marked |
Natural Death |
Alimentary System |
Mesentery |
|
500 mg/kg |
4 |
108 |
108 |
731 |
1 |
Hemorrhage |
Marked |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Acinus |
250 mg/kg |
50 |
89 |
89 |
732 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Acinus |
500 mg/kg |
50 |
128 |
128 |
540 |
1 |
Atrophy |
Mild |
Moribund Sacrifice |
Alimentary System |
Pancreas |
Arteriole |
250 mg/kg |
50 |
99 |
99 |
713 |
1 |
Fibrosis |
Mild |
Moribund Sacrifice |
Alimentary System |
Pancreas |
|
500 mg/kg |
50 |
113 |
113 |
731 |
1 |
Basophilic Focus |
|
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
500 mg/kg |
50 |
148 |
148 |
730 |
1 |
Hyperkeratosis |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
1000 mg/kg |
50 |
171 |
171 |
385 |
1 |
Hyperkeratosis |
Marked |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
Vehicle Control |
50 |
10 |
10 |
673 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
Vehicle Control |
50 |
41 |
41 |
699 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
Vehicle Control |
50 |
21 |
21 |
732 |
1 |
Infiltration Cellular |
Mild, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
Vehicle Control |
50 |
29 |
29 |
731 |
1 |
Infiltration Cellular |
Mild, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
Vehicle Control |
50 |
31 |
31 |
730 |
1 |
Infiltration Cellular |
Mild, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
250 mg/kg |
50 |
69 |
69 |
729 |
1 |
Infiltration Cellular |
Moderate, Mononuclear Cl |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach |
250 mg/kg |
50 |
70 |
70 |
613 |
1 |
Infiltration Cellular |
Mild, Mononuclear Cl |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach |
250 mg/kg |
50 |
93 |
93 |
657 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
250 mg/kg |
50 |
52 |
52 |
732 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
250 mg/kg |
50 |
63 |
63 |
732 |
1 |
Infiltration Cellular |
Mild, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
250 mg/kg |
50 |
68 |
68 |
732 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
250 mg/kg |
50 |
74 |
74 |
732 |
1 |
Infiltration Cellular |
Mild, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
250 mg/kg |
50 |
83 |
83 |
730 |
1 |
Infiltration Cellular |
Mild, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
500 mg/kg |
50 |
102 |
102 |
568 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach |
500 mg/kg |
50 |
119 |
119 |
613 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach |
500 mg/kg |
50 |
123 |
123 |
674 |
1 |
Infiltration Cellular |
Mild, Mononuclear Cl |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach |
500 mg/kg |
50 |
128 |
128 |
540 |
1 |
Infiltration Cellular |
Mild, Mononuclear Cl |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach |
500 mg/kg |
50 |
147 |
147 |
668 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach |
500 mg/kg |
50 |
111 |
111 |
577 |
1 |
Infiltration Cellular |
Moderate, Mononuclear Cl |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
500 mg/kg |
50 |
114 |
114 |
535 |
1 |
Infiltration Cellular |
Moderate, Mononuclear Cl |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
500 mg/kg |
50 |
116 |
116 |
722 |
1 |
Infiltration Cellular |
Mild, Mononuclear Cl |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
500 mg/kg |
50 |
104 |
104 |
731 |
1 |
Infiltration Cellular |
Mild, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
500 mg/kg |
50 |
108 |
108 |
731 |
1 |
Infiltration Cellular |
Mild, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
500 mg/kg |
50 |
110 |
110 |
731 |
1 |
Infiltration Cellular |
Mild, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
500 mg/kg |
50 |
112 |
112 |
732 |
1 |
Infiltration Cellular |
Moderate, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
500 mg/kg |
50 |
117 |
117 |
731 |
1 |
Infiltration Cellular |
Moderate, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
500 mg/kg |
50 |
120 |
120 |
731 |
1 |
Infiltration Cellular |
Mild, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
500 mg/kg |
50 |
121 |
121 |
732 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
500 mg/kg |
50 |
122 |
122 |
730 |
1 |
Infiltration Cellular |
Mild, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
500 mg/kg |
50 |
124 |
124 |
731 |
1 |
Infiltration Cellular |
Moderate, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
500 mg/kg |
50 |
125 |
125 |
732 |
1 |
Infiltration Cellular |
Mild, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
500 mg/kg |
50 |
129 |
129 |
732 |
1 |
Infiltration Cellular |
Mild, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
500 mg/kg |
50 |
130 |
130 |
731 |
1 |
Infiltration Cellular |
Mild, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
500 mg/kg |
50 |
135 |
135 |
732 |
1 |
Infiltration Cellular |
Moderate, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
1000 mg/kg |
50 |
156 |
156 |
585 |
1 |
Infiltration Cellular |
Mild, Mononuclear Cl |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach |
1000 mg/kg |
50 |
170 |
170 |
633 |
1 |
Infiltration Cellular |
Moderate, Mononuclear Cl |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach |
1000 mg/kg |
50 |
178 |
178 |
613 |
1 |
Infiltration Cellular |
Mild, Mononuclear Cl |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach |
1000 mg/kg |
50 |
180 |
180 |
213 |
1 |
Infiltration Cellular |
Marked, Mononuclear Cl |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach |
1000 mg/kg |
50 |
191 |
191 |
667 |
1 |
Infiltration Cellular |
Mild, Mononuclear Cl |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach |
1000 mg/kg |
50 |
154 |
154 |
686 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
1000 mg/kg |
50 |
155 |
155 |
609 |
1 |
Infiltration Cellular |
Mild, Mononuclear Cl |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
1000 mg/kg |
50 |
158 |
158 |
686 |
1 |
Infiltration Cellular |
Mild, Mononuclear Cl |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
1000 mg/kg |
50 |
160 |
160 |
421 |
1 |
Infiltration Cellular |
Mild, Mononuclear Cl |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
1000 mg/kg |
50 |
163 |
163 |
718 |
1 |
Infiltration Cellular |
Moderate, Mononuclear Cl |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
1000 mg/kg |
50 |
169 |
169 |
537 |
1 |
Infiltration Cellular |
Moderate, Mononuclear Cl |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
1000 mg/kg |
50 |
171 |
171 |
385 |
1 |
Infiltration Cellular |
Moderate, Mononuclear Cl |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
1000 mg/kg |
50 |
173 |
173 |
411 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
1000 mg/kg |
50 |
179 |
179 |
233 |
1 |
Infiltration Cellular |
Mild, Mononuclear Cl |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
1000 mg/kg |
50 |
182 |
182 |
548 |
1 |
Infiltration Cellular |
Mild, Mononuclear Cl |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
1000 mg/kg |
50 |
187 |
187 |
704 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
1000 mg/kg |
50 |
189 |
189 |
661 |
1 |
Infiltration Cellular |
Mild, Mononuclear Cl |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
1000 mg/kg |
50 |
200 |
200 |
704 |
1 |
Infiltration Cellular |
Mild, Mononuclear Cl |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
1000 mg/kg |
50 |
151 |
151 |
731 |
1 |
Infiltration Cellular |
Mild, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
1000 mg/kg |
50 |
153 |
153 |
732 |
1 |
Infiltration Cellular |
Marked, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
1000 mg/kg |
50 |
159 |
159 |
731 |
1 |
Infiltration Cellular |
Moderate, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
1000 mg/kg |
50 |
161 |
161 |
731 |
1 |
Infiltration Cellular |
Mild, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
1000 mg/kg |
50 |
172 |
172 |
730 |
1 |
Infiltration Cellular |
Moderate, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
1000 mg/kg |
50 |
176 |
176 |
730 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
1000 mg/kg |
50 |
181 |
181 |
731 |
1 |
Infiltration Cellular |
Mild, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
1000 mg/kg |
50 |
184 |
184 |
732 |
1 |
Infiltration Cellular |
Moderate, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
1000 mg/kg |
50 |
186 |
186 |
730 |
1 |
Infiltration Cellular |
Mild, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
Vehicle Control |
50 |
14 |
14 |
501 |
1 |
Inflammation |
Minimal |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach |
Vehicle Control |
50 |
34 |
34 |
645 |
1 |
Inflammation |
Mild |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach |
Vehicle Control |
50 |
48 |
48 |
640 |
1 |
Inflammation |
Minimal |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach |
Vehicle Control |
50 |
10 |
10 |
673 |
1 |
Inflammation |
Minimal |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
Vehicle Control |
50 |
41 |
41 |
699 |
1 |
Inflammation |
Mild |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
Vehicle Control |
50 |
21 |
21 |
732 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
Vehicle Control |
50 |
29 |
29 |
731 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
Vehicle Control |
50 |
31 |
31 |
730 |
1 |
Inflammation |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
Vehicle Control |
50 |
36 |
36 |
730 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
250 mg/kg |
50 |
69 |
69 |
729 |
1 |
Inflammation |
Mild |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach |
250 mg/kg |
50 |
51 |
51 |
602 |
1 |
Inflammation |
Minimal |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
250 mg/kg |
50 |
55 |
55 |
664 |
1 |
Inflammation |
Minimal |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
250 mg/kg |
50 |
71 |
71 |
589 |
1 |
Inflammation |
Moderate |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
250 mg/kg |
50 |
93 |
93 |
657 |
1 |
Inflammation |
Minimal |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
250 mg/kg |
50 |
52 |
52 |
732 |
1 |
Inflammation |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
250 mg/kg |
50 |
63 |
63 |
732 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
250 mg/kg |
50 |
68 |
68 |
732 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
250 mg/kg |
50 |
74 |
74 |
732 |
1 |
Inflammation |
Moderate |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
250 mg/kg |
50 |
83 |
83 |
730 |
1 |
Inflammation |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
500 mg/kg |
50 |
119 |
119 |
613 |
1 |
Inflammation |
Minimal |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach |
500 mg/kg |
50 |
123 |
123 |
674 |
1 |
Inflammation |
Mild |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach |
500 mg/kg |
50 |
128 |
128 |
540 |
1 |
Inflammation |
Moderate |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach |
500 mg/kg |
50 |
111 |
111 |
577 |
1 |
Inflammation |
Moderate |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
500 mg/kg |
50 |
114 |
114 |
535 |
1 |
Inflammation |
Mild |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
500 mg/kg |
50 |
116 |
116 |
722 |
1 |
Inflammation |
Mild |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
500 mg/kg |
50 |
145 |
145 |
522 |
1 |
Inflammation |
Minimal |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
500 mg/kg |
50 |
104 |
104 |
731 |
1 |
Inflammation |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
500 mg/kg |
50 |
108 |
108 |
731 |
1 |
Inflammation |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
500 mg/kg |
50 |
109 |
109 |
731 |
1 |
Inflammation |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
500 mg/kg |
50 |
110 |
110 |
731 |
1 |
Inflammation |
Moderate |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
500 mg/kg |
50 |
112 |
112 |
732 |
1 |
Inflammation |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
500 mg/kg |
50 |
117 |
117 |
731 |
1 |
Inflammation |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
500 mg/kg |
50 |
120 |
120 |
731 |
1 |
Inflammation |
Moderate |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
500 mg/kg |
50 |
122 |
122 |
730 |
1 |
Inflammation |
Moderate |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
500 mg/kg |
50 |
124 |
124 |
731 |
1 |
Inflammation |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
500 mg/kg |
50 |
125 |
125 |
732 |
1 |
Inflammation |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
500 mg/kg |
50 |
129 |
129 |
732 |
1 |
Inflammation |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
500 mg/kg |
50 |
130 |
130 |
731 |
1 |
Inflammation |
Moderate |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
500 mg/kg |
50 |
135 |
135 |
732 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
1000 mg/kg |
50 |
156 |
156 |
585 |
1 |
Inflammation |
Minimal |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach |
1000 mg/kg |
50 |
170 |
170 |
633 |
1 |
Inflammation |
Mild |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach |
1000 mg/kg |
50 |
178 |
178 |
613 |
1 |
Inflammation |
Moderate |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach |
1000 mg/kg |
50 |
180 |
180 |
213 |
1 |
Inflammation |
Moderate |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach |
1000 mg/kg |
50 |
191 |
191 |
667 |
1 |
Inflammation |
Minimal |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach |
1000 mg/kg |
50 |
155 |
155 |
609 |
1 |
Inflammation |
Mild |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
1000 mg/kg |
50 |
158 |
158 |
686 |
1 |
Inflammation |
Mild |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
1000 mg/kg |
50 |
160 |
160 |
421 |
1 |
Inflammation |
Mild |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
1000 mg/kg |
50 |
163 |
163 |
718 |
1 |
Inflammation |
Marked |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
1000 mg/kg |
50 |
169 |
169 |
537 |
1 |
Inflammation |
Marked |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
1000 mg/kg |
50 |
171 |
171 |
385 |
1 |
Inflammation |
Mild |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
1000 mg/kg |
50 |
173 |
173 |
411 |
1 |
Inflammation |
Moderate |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
1000 mg/kg |
50 |
179 |
179 |
233 |
1 |
Inflammation |
Moderate |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
1000 mg/kg |
50 |
182 |
182 |
548 |
1 |
Inflammation |
Moderate |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
1000 mg/kg |
50 |
187 |
187 |
704 |
1 |
Inflammation |
Mild |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
1000 mg/kg |
50 |
189 |
189 |
661 |
1 |
Inflammation |
Mild |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
1000 mg/kg |
50 |
193 |
193 |
484 |
1 |
Inflammation |
Minimal |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
1000 mg/kg |
50 |
151 |
151 |
731 |
1 |
Inflammation |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
1000 mg/kg |
50 |
153 |
153 |
732 |
1 |
Inflammation |
Moderate |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
1000 mg/kg |
50 |
159 |
159 |
731 |
1 |
Inflammation |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
1000 mg/kg |
50 |
161 |
161 |
731 |
1 |
Inflammation |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
1000 mg/kg |
50 |
172 |
172 |
730 |
1 |
Inflammation |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
1000 mg/kg |
50 |
176 |
176 |
730 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
1000 mg/kg |
50 |
181 |
181 |
731 |
1 |
Inflammation |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
1000 mg/kg |
50 |
184 |
184 |
732 |
1 |
Inflammation |
Moderate |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
1000 mg/kg |
50 |
186 |
186 |
730 |
1 |
Inflammation |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
Vehicle Control |
50 |
14 |
14 |
501 |
1 |
Ulcer |
Mild |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach |
Vehicle Control |
50 |
34 |
34 |
645 |
1 |
Ulcer |
Mild |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach |
Vehicle Control |
50 |
48 |
48 |
640 |
1 |
Ulcer |
Minimal |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach |
Vehicle Control |
50 |
10 |
10 |
673 |
1 |
Ulcer |
Minimal |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
Vehicle Control |
50 |
41 |
41 |
699 |
1 |
Ulcer |
Mild |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
Vehicle Control |
50 |
21 |
21 |
732 |
1 |
Ulcer |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
Vehicle Control |
50 |
29 |
29 |
731 |
1 |
Ulcer |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
Vehicle Control |
50 |
31 |
31 |
730 |
1 |
Ulcer |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
Vehicle Control |
50 |
36 |
36 |
730 |
1 |
Ulcer |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
250 mg/kg |
50 |
69 |
69 |
729 |
1 |
Ulcer |
Moderate |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach |
250 mg/kg |
50 |
70 |
70 |
613 |
1 |
Ulcer |
Mild |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach |
250 mg/kg |
50 |
55 |
55 |
664 |
1 |
Ulcer |
Minimal |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
250 mg/kg |
50 |
71 |
71 |
589 |
1 |
Ulcer |
Marked |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
250 mg/kg |
50 |
93 |
93 |
657 |
1 |
Ulcer |
Mild |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
250 mg/kg |
50 |
52 |
52 |
732 |
1 |
Ulcer |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
250 mg/kg |
50 |
68 |
68 |
732 |
1 |
Ulcer |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
250 mg/kg |
50 |
74 |
74 |
732 |
1 |
Ulcer |
Marked |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
250 mg/kg |
50 |
83 |
83 |
730 |
1 |
Ulcer |
Moderate |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
500 mg/kg |
50 |
119 |
119 |
613 |
1 |
Ulcer |
Minimal |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach |
500 mg/kg |
50 |
123 |
123 |
674 |
1 |
Ulcer |
Moderate |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach |
500 mg/kg |
50 |
128 |
128 |
540 |
1 |
Ulcer |
Mild |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach |
500 mg/kg |
50 |
111 |
111 |
577 |
1 |
Ulcer |
Moderate |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
500 mg/kg |
50 |
114 |
114 |
535 |
1 |
Ulcer |
Mild |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
500 mg/kg |
50 |
116 |
116 |
722 |
1 |
Ulcer |
Mild |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
500 mg/kg |
50 |
104 |
104 |
731 |
1 |
Ulcer |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
500 mg/kg |
50 |
108 |
108 |
731 |
1 |
Ulcer |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
500 mg/kg |
50 |
109 |
109 |
731 |
1 |
Ulcer |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
500 mg/kg |
50 |
110 |
110 |
731 |
1 |
Ulcer |
Moderate |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
500 mg/kg |
50 |
112 |
112 |
732 |
1 |
Ulcer |
Moderate |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
500 mg/kg |
50 |
117 |
117 |
731 |
1 |
Ulcer |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
500 mg/kg |
50 |
120 |
120 |
731 |
1 |
Ulcer |
Moderate |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
500 mg/kg |
50 |
122 |
122 |
730 |
1 |
Ulcer |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
500 mg/kg |
50 |
124 |
124 |
731 |
1 |
Ulcer |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
500 mg/kg |
50 |
125 |
125 |
732 |
1 |
Ulcer |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
500 mg/kg |
50 |
129 |
129 |
732 |
1 |
Ulcer |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
500 mg/kg |
50 |
130 |
130 |
731 |
1 |
Ulcer |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
500 mg/kg |
50 |
135 |
135 |
732 |
1 |
Ulcer |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
1000 mg/kg |
50 |
156 |
156 |
585 |
1 |
Ulcer |
Mild |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach |
1000 mg/kg |
50 |
170 |
170 |
633 |
1 |
Ulcer |
Mild |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach |
1000 mg/kg |
50 |
178 |
178 |
613 |
1 |
Ulcer |
Marked |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach |
1000 mg/kg |
50 |
180 |
180 |
213 |
1 |
Ulcer |
Moderate |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach |
1000 mg/kg |
50 |
191 |
191 |
667 |
1 |
Ulcer |
Mild |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach |
1000 mg/kg |
50 |
154 |
154 |
686 |
1 |
Ulcer |
Minimal |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
1000 mg/kg |
50 |
155 |
155 |
609 |
1 |
Ulcer |
Mild |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
1000 mg/kg |
50 |
158 |
158 |
686 |
1 |
Ulcer |
Mild |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
1000 mg/kg |
50 |
160 |
160 |
421 |
1 |
Ulcer |
Mild |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
1000 mg/kg |
50 |
163 |
163 |
718 |
1 |
Ulcer |
Marked |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
1000 mg/kg |
50 |
169 |
169 |
537 |
1 |
Ulcer |
Moderate |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
1000 mg/kg |
50 |
171 |
171 |
385 |
1 |
Ulcer |
Mild |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
1000 mg/kg |
50 |
173 |
173 |
411 |
1 |
Ulcer |
Moderate |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
1000 mg/kg |
50 |
179 |
179 |
233 |
1 |
Ulcer |
Mild |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
1000 mg/kg |
50 |
182 |
182 |
548 |
1 |
Ulcer |
Moderate |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
1000 mg/kg |
50 |
187 |
187 |
704 |
1 |
Ulcer |
Moderate |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
1000 mg/kg |
50 |
189 |
189 |
661 |
1 |
Ulcer |
Moderate |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
1000 mg/kg |
50 |
193 |
193 |
484 |
1 |
Ulcer |
Minimal |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
1000 mg/kg |
50 |
195 |
195 |
408 |
1 |
Ulcer |
Minimal |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
1000 mg/kg |
50 |
200 |
200 |
704 |
1 |
Ulcer |
Mild |
Natural Death |
Alimentary System |
Stomach |
Forestomach |
1000 mg/kg |
50 |
151 |
151 |
731 |
1 |
Ulcer |
Moderate |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
1000 mg/kg |
50 |
153 |
153 |
732 |
1 |
Ulcer |
Moderate |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
1000 mg/kg |
50 |
159 |
159 |
731 |
1 |
Ulcer |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
1000 mg/kg |
50 |
161 |
161 |
731 |
1 |
Ulcer |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
1000 mg/kg |
50 |
172 |
172 |
730 |
1 |
Ulcer |
Moderate |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
1000 mg/kg |
50 |
176 |
176 |
730 |
1 |
Ulcer |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
1000 mg/kg |
50 |
184 |
184 |
732 |
1 |
Ulcer |
Moderate |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
1000 mg/kg |
50 |
186 |
186 |
730 |
1 |
Ulcer |
Moderate |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
Vehicle Control |
50 |
14 |
14 |
501 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
Vehicle Control |
50 |
34 |
34 |
645 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
Vehicle Control |
50 |
48 |
48 |
640 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
Vehicle Control |
50 |
13 |
13 |
683 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Alimentary System |
Stomach |
Forestomach, Epithelium |
Vehicle Control |
50 |
41 |
41 |
699 |
1 |
Hyperplasia |
Moderate |
Natural Death |
Alimentary System |
Stomach |
Forestomach, Epithelium |
Vehicle Control |
50 |
21 |
21 |
732 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
Vehicle Control |
50 |
29 |
29 |
731 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
Vehicle Control |
50 |
31 |
31 |
730 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
Vehicle Control |
50 |
33 |
33 |
731 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
Vehicle Control |
50 |
36 |
36 |
730 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
250 mg/kg |
50 |
69 |
69 |
729 |
1 |
Hyperplasia |
Moderate |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
250 mg/kg |
50 |
70 |
70 |
613 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
250 mg/kg |
50 |
51 |
51 |
602 |
1 |
Hyperplasia |
Mild |
Natural Death |
Alimentary System |
Stomach |
Forestomach, Epithelium |
250 mg/kg |
50 |
71 |
71 |
589 |
1 |
Hyperplasia |
Moderate |
Natural Death |
Alimentary System |
Stomach |
Forestomach, Epithelium |
250 mg/kg |
50 |
76 |
76 |
608 |
1 |
Hyperplasia |
Mild |
Natural Death |
Alimentary System |
Stomach |
Forestomach, Epithelium |
250 mg/kg |
50 |
52 |
52 |
732 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
250 mg/kg |
50 |
53 |
53 |
731 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
250 mg/kg |
50 |
63 |
63 |
732 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
250 mg/kg |
50 |
68 |
68 |
732 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
250 mg/kg |
50 |
74 |
74 |
732 |
1 |
Hyperplasia |
Marked |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
250 mg/kg |
50 |
77 |
77 |
732 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
250 mg/kg |
50 |
82 |
82 |
730 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
250 mg/kg |
50 |
83 |
83 |
730 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
500 mg/kg |
50 |
102 |
102 |
568 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
500 mg/kg |
50 |
119 |
119 |
613 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
500 mg/kg |
50 |
123 |
123 |
674 |
1 |
Hyperplasia |
Marked |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
500 mg/kg |
50 |
128 |
128 |
540 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
500 mg/kg |
50 |
147 |
147 |
668 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
500 mg/kg |
50 |
111 |
111 |
577 |
1 |
Hyperplasia |
Moderate |
Natural Death |
Alimentary System |
Stomach |
Forestomach, Epithelium |
500 mg/kg |
50 |
114 |
114 |
535 |
1 |
Hyperplasia |
Marked |
Natural Death |
Alimentary System |
Stomach |
Forestomach, Epithelium |
500 mg/kg |
50 |
116 |
116 |
722 |
1 |
Hyperplasia |
Marked |
Natural Death |
Alimentary System |
Stomach |
Forestomach, Epithelium |
500 mg/kg |
50 |
145 |
145 |
522 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Alimentary System |
Stomach |
Forestomach, Epithelium |
500 mg/kg |
50 |
104 |
104 |
731 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
500 mg/kg |
50 |
108 |
108 |
731 |
1 |
Hyperplasia |
Marked |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
500 mg/kg |
50 |
109 |
109 |
731 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
500 mg/kg |
50 |
110 |
110 |
731 |
1 |
Hyperplasia |
Marked |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
500 mg/kg |
50 |
112 |
112 |
732 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
500 mg/kg |
50 |
117 |
117 |
731 |
1 |
Hyperplasia |
Marked |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
500 mg/kg |
50 |
120 |
120 |
731 |
1 |
Hyperplasia |
Marked |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
500 mg/kg |
50 |
121 |
121 |
732 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
500 mg/kg |
50 |
122 |
122 |
730 |
1 |
Hyperplasia |
Marked |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
500 mg/kg |
50 |
124 |
124 |
731 |
1 |
Hyperplasia |
Marked |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
500 mg/kg |
50 |
125 |
125 |
732 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
500 mg/kg |
50 |
129 |
129 |
732 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
500 mg/kg |
50 |
130 |
130 |
731 |
1 |
Hyperplasia |
Marked |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
500 mg/kg |
50 |
135 |
135 |
732 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
500 mg/kg |
50 |
137 |
137 |
731 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
500 mg/kg |
50 |
142 |
142 |
731 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
500 mg/kg |
50 |
149 |
149 |
732 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
500 mg/kg |
50 |
150 |
150 |
731 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
1000 mg/kg |
50 |
156 |
156 |
585 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
1000 mg/kg |
50 |
170 |
170 |
633 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
1000 mg/kg |
50 |
178 |
178 |
613 |
1 |
Hyperplasia |
Marked |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
1000 mg/kg |
50 |
180 |
180 |
213 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
1000 mg/kg |
50 |
191 |
191 |
667 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
1000 mg/kg |
50 |
154 |
154 |
686 |
1 |
Hyperplasia |
Moderate |
Natural Death |
Alimentary System |
Stomach |
Forestomach, Epithelium |
1000 mg/kg |
50 |
155 |
155 |
609 |
1 |
Hyperplasia |
Moderate |
Natural Death |
Alimentary System |
Stomach |
Forestomach, Epithelium |
1000 mg/kg |
50 |
158 |
158 |
686 |
1 |
Hyperplasia |
Mild |
Natural Death |
Alimentary System |
Stomach |
Forestomach, Epithelium |
1000 mg/kg |
50 |
160 |
160 |
421 |
1 |
Hyperplasia |
Moderate |
Natural Death |
Alimentary System |
Stomach |
Forestomach, Epithelium |
1000 mg/kg |
50 |
163 |
163 |
718 |
1 |
Hyperplasia |
Marked |
Natural Death |
Alimentary System |
Stomach |
Forestomach, Epithelium |
1000 mg/kg |
50 |
169 |
169 |
537 |
1 |
Hyperplasia |
Moderate |
Natural Death |
Alimentary System |
Stomach |
Forestomach, Epithelium |
1000 mg/kg |
50 |
171 |
171 |
385 |
1 |
Hyperplasia |
Moderate |
Natural Death |
Alimentary System |
Stomach |
Forestomach, Epithelium |
1000 mg/kg |
50 |
173 |
173 |
411 |
1 |
Hyperplasia |
Mild |
Natural Death |
Alimentary System |
Stomach |
Forestomach, Epithelium |
1000 mg/kg |
50 |
179 |
179 |
233 |
1 |
Hyperplasia |
Moderate |
Natural Death |
Alimentary System |
Stomach |
Forestomach, Epithelium |
1000 mg/kg |
50 |
182 |
182 |
548 |
1 |
Hyperplasia |
Moderate |
Natural Death |
Alimentary System |
Stomach |
Forestomach, Epithelium |
1000 mg/kg |
50 |
187 |
187 |
704 |
1 |
Hyperplasia |
Marked |
Natural Death |
Alimentary System |
Stomach |
Forestomach, Epithelium |
1000 mg/kg |
50 |
189 |
189 |
661 |
1 |
Hyperplasia |
Mild |
Natural Death |
Alimentary System |
Stomach |
Forestomach, Epithelium |
1000 mg/kg |
50 |
193 |
193 |
484 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Alimentary System |
Stomach |
Forestomach, Epithelium |
1000 mg/kg |
50 |
194 |
194 |
424 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Alimentary System |
Stomach |
Forestomach, Epithelium |
1000 mg/kg |
50 |
200 |
200 |
704 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Alimentary System |
Stomach |
Forestomach, Epithelium |
1000 mg/kg |
50 |
151 |
151 |
731 |
1 |
Hyperplasia |
Marked |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
1000 mg/kg |
50 |
153 |
153 |
732 |
1 |
Hyperplasia |
Marked |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
1000 mg/kg |
50 |
159 |
159 |
731 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
1000 mg/kg |
50 |
161 |
161 |
731 |
1 |
Hyperplasia |
Marked |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
1000 mg/kg |
50 |
172 |
172 |
730 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
1000 mg/kg |
50 |
176 |
176 |
730 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
1000 mg/kg |
50 |
184 |
184 |
732 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
1000 mg/kg |
50 |
186 |
186 |
730 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Alimentary System |
Stomach |
Glandular |
Vehicle Control |
50 |
49 |
49 |
732 |
1 |
Cyst |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Glandular |
Vehicle Control |
50 |
38 |
38 |
732 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Glandular |
500 mg/kg |
50 |
128 |
128 |
540 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Alimentary System |
Stomach |
Glandular |
500 mg/kg |
50 |
122 |
122 |
730 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Glandular |
500 mg/kg |
50 |
143 |
143 |
732 |
1 |
Hyperplasia |
Mild, Focal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Glandular |
1000 mg/kg |
50 |
153 |
153 |
732 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Tooth |
|
Vehicle Control |
14 |
14 |
14 |
501 |
1 |
Dysplasia |
Mild |
Moribund Sacrifice |
Alimentary System |
Tooth |
|
Vehicle Control |
14 |
15 |
15 |
644 |
1 |
Dysplasia |
Mild |
Moribund Sacrifice |
Alimentary System |
Tooth |
|
Vehicle Control |
14 |
34 |
34 |
645 |
1 |
Dysplasia |
Moderate |
Moribund Sacrifice |
Alimentary System |
Tooth |
|
Vehicle Control |
14 |
40 |
40 |
730 |
1 |
Dysplasia |
Moderate |
Moribund Sacrifice |
Alimentary System |
Tooth |
|
Vehicle Control |
14 |
26 |
26 |
640 |
1 |
Dysplasia |
Marked |
Natural Death |
Alimentary System |
Tooth |
|
Vehicle Control |
14 |
43 |
43 |
661 |
1 |
Dysplasia |
Minimal |
Natural Death |
Alimentary System |
Tooth |
|
Vehicle Control |
14 |
20 |
20 |
732 |
1 |
Dysplasia |
Marked |
Terminal Sacrifice |
Alimentary System |
Tooth |
|
Vehicle Control |
14 |
25 |
25 |
731 |
1 |
Dysplasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Tooth |
|
Vehicle Control |
14 |
31 |
31 |
730 |
1 |
Dysplasia |
Moderate |
Terminal Sacrifice |
Alimentary System |
Tooth |
|
Vehicle Control |
14 |
37 |
37 |
732 |
1 |
Dysplasia |
Marked |
Terminal Sacrifice |
Alimentary System |
Tooth |
|
Vehicle Control |
14 |
7 |
7 |
732 |
1 |
Dysplasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Tooth |
|
250 mg/kg |
9 |
65 |
65 |
693 |
1 |
Dysplasia |
Mild |
Moribund Sacrifice |
Alimentary System |
Tooth |
|
250 mg/kg |
9 |
66 |
66 |
535 |
1 |
Dysplasia |
Mild |
Moribund Sacrifice |
Alimentary System |
Tooth |
|
250 mg/kg |
9 |
75 |
75 |
708 |
1 |
Dysplasia |
Minimal |
Moribund Sacrifice |
Alimentary System |
Tooth |
|
250 mg/kg |
9 |
88 |
88 |
714 |
1 |
Dysplasia |
Minimal |
Moribund Sacrifice |
Alimentary System |
Tooth |
|
250 mg/kg |
9 |
99 |
99 |
713 |
1 |
Dysplasia |
Marked |
Moribund Sacrifice |
Alimentary System |
Tooth |
|
250 mg/kg |
9 |
74 |
74 |
732 |
1 |
Dysplasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Tooth |
|
250 mg/kg |
9 |
82 |
82 |
730 |
1 |
Dysplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Tooth |
|
250 mg/kg |
9 |
96 |
96 |
732 |
1 |
Dysplasia |
Moderate |
Terminal Sacrifice |
Alimentary System |
Tooth |
|
500 mg/kg |
9 |
101 |
101 |
731 |
1 |
Dysplasia |
Moderate |
Terminal Sacrifice |
Alimentary System |
Tooth |
|
500 mg/kg |
9 |
105 |
105 |
731 |
1 |
Dysplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Tooth |
|
500 mg/kg |
9 |
125 |
125 |
732 |
1 |
Dysplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Tooth |
|
500 mg/kg |
9 |
126 |
126 |
732 |
1 |
Dysplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Tooth |
|
500 mg/kg |
9 |
129 |
129 |
732 |
1 |
Dysplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Tooth |
|
500 mg/kg |
9 |
130 |
130 |
731 |
1 |
Dysplasia |
Mild |
Terminal Sacrifice |
Alimentary System |
Tooth |
|
500 mg/kg |
9 |
133 |
133 |
730 |
1 |
Dysplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Tooth |
|
500 mg/kg |
9 |
141 |
141 |
731 |
1 |
Dysplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Tooth |
|
500 mg/kg |
9 |
149 |
149 |
732 |
1 |
Dysplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Tooth |
|
1000 mg/kg |
2 |
172 |
172 |
730 |
1 |
Dysplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Tooth |
|
1000 mg/kg |
2 |
183 |
183 |
731 |
1 |
Dysplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Tooth |
|
Vehicle Control |
14 |
5 |
5 |
731 |
1 |
Inflammation |
Moderate |
Terminal Sacrifice |
Alimentary System |
Tooth |
|
250 mg/kg |
9 |
74 |
74 |
732 |
1 |
Inflammation |
Moderate |
Terminal Sacrifice |
Alimentary System |
Tooth |
|
500 mg/kg |
9 |
149 |
149 |
732 |
1 |
Inflammation |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Blood Vessel |
|
Vehicle Control |
50 |
36 |
36 |
730 |
1 |
Inflammation |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Blood Vessel |
|
1000 mg/kg |
50 |
160 |
160 |
421 |
1 |
Inflammation |
Mild |
Natural Death |
Cardiovascular System |
Blood Vessel |
|
1000 mg/kg |
50 |
169 |
169 |
537 |
1 |
Inflammation |
Mild |
Natural Death |
Cardiovascular System |
Heart |
Atrium |
250 mg/kg |
50 |
73 |
73 |
697 |
1 |
Thrombosis |
Marked |
Moribund Sacrifice |
Cardiovascular System |
Heart |
Atrium |
500 mg/kg |
50 |
123 |
123 |
674 |
1 |
Thrombosis |
Marked |
Moribund Sacrifice |
Cardiovascular System |
Heart |
Myocardium |
Vehicle Control |
50 |
14 |
14 |
501 |
1 |
Necrosis |
Mild |
Moribund Sacrifice |
Cardiovascular System |
Heart |
Pericardium |
Vehicle Control |
50 |
34 |
34 |
645 |
1 |
Fibrosis |
Mild |
Moribund Sacrifice |
Cardiovascular System |
Heart |
Valve |
500 mg/kg |
50 |
117 |
117 |
731 |
1 |
Degeneration |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
Valve |
Vehicle Control |
50 |
41 |
41 |
699 |
1 |
Inflammation |
Marked |
Natural Death |
Cardiovascular System |
Heart |
Valve |
Vehicle Control |
50 |
50 |
50 |
374 |
1 |
Inflammation |
Marked |
Natural Death |
Cardiovascular System |
Heart |
Valve |
250 mg/kg |
50 |
59 |
59 |
403 |
1 |
Inflammation |
Marked |
Natural Death |
Cardiovascular System |
Heart |
Valve |
250 mg/kg |
50 |
85 |
85 |
426 |
1 |
Inflammation |
Marked |
Natural Death |
Cardiovascular System |
Heart |
|
Vehicle Control |
50 |
18 |
18 |
714 |
1 |
Cardiomyopathy |
Minimal |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
50 |
40 |
40 |
730 |
1 |
Cardiomyopathy |
Minimal |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
50 |
48 |
48 |
640 |
1 |
Cardiomyopathy |
Minimal |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
50 |
17 |
17 |
731 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
50 |
19 |
19 |
731 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
50 |
2 |
2 |
731 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
50 |
20 |
20 |
732 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
50 |
21 |
21 |
732 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
50 |
22 |
22 |
732 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
50 |
27 |
27 |
732 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
50 |
28 |
28 |
731 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
50 |
29 |
29 |
731 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
50 |
3 |
3 |
730 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
50 |
32 |
32 |
731 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
50 |
35 |
35 |
730 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
50 |
36 |
36 |
730 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
50 |
4 |
4 |
732 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
50 |
44 |
44 |
732 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
50 |
45 |
45 |
732 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
50 |
46 |
46 |
730 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
50 |
49 |
49 |
732 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
50 |
5 |
5 |
731 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
50 |
7 |
7 |
732 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
50 |
9 |
9 |
731 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
250 mg/kg |
50 |
69 |
69 |
729 |
1 |
Cardiomyopathy |
Minimal |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
250 mg/kg |
50 |
73 |
73 |
697 |
1 |
Cardiomyopathy |
Minimal |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
250 mg/kg |
50 |
81 |
81 |
700 |
1 |
Cardiomyopathy |
Minimal |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
250 mg/kg |
50 |
88 |
88 |
714 |
1 |
Cardiomyopathy |
Minimal |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
250 mg/kg |
50 |
93 |
93 |
657 |
1 |
Cardiomyopathy |
Mild |
Natural Death |
Cardiovascular System |
Heart |
|
250 mg/kg |
50 |
97 |
97 |
470 |
1 |
Cardiomyopathy |
Minimal |
Natural Death |
Cardiovascular System |
Heart |
|
250 mg/kg |
50 |
53 |
53 |
731 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
250 mg/kg |
50 |
61 |
61 |
732 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
250 mg/kg |
50 |
63 |
63 |
732 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
250 mg/kg |
50 |
68 |
68 |
732 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
250 mg/kg |
50 |
74 |
74 |
732 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
250 mg/kg |
50 |
77 |
77 |
732 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
250 mg/kg |
50 |
78 |
78 |
732 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
250 mg/kg |
50 |
80 |
80 |
732 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
250 mg/kg |
50 |
82 |
82 |
730 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
250 mg/kg |
50 |
83 |
83 |
730 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
250 mg/kg |
50 |
84 |
84 |
732 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
250 mg/kg |
50 |
89 |
89 |
732 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
250 mg/kg |
50 |
91 |
91 |
730 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
250 mg/kg |
50 |
95 |
95 |
732 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
500 mg/kg |
50 |
119 |
119 |
613 |
1 |
Cardiomyopathy |
Minimal |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
500 mg/kg |
50 |
147 |
147 |
668 |
1 |
Cardiomyopathy |
Mild |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
500 mg/kg |
50 |
116 |
116 |
722 |
1 |
Cardiomyopathy |
Minimal |
Natural Death |
Cardiovascular System |
Heart |
|
500 mg/kg |
50 |
145 |
145 |
522 |
1 |
Cardiomyopathy |
Minimal |
Natural Death |
Cardiovascular System |
Heart |
|
500 mg/kg |
50 |
105 |
105 |
731 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
500 mg/kg |
50 |
109 |
109 |
731 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
500 mg/kg |
50 |
112 |
112 |
732 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
500 mg/kg |
50 |
115 |
115 |
730 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
500 mg/kg |
50 |
121 |
121 |
732 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
500 mg/kg |
50 |
125 |
125 |
732 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
500 mg/kg |
50 |
129 |
129 |
732 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
500 mg/kg |
50 |
132 |
132 |
731 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
500 mg/kg |
50 |
135 |
135 |
732 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
500 mg/kg |
50 |
136 |
136 |
730 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
500 mg/kg |
50 |
137 |
137 |
731 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
500 mg/kg |
50 |
142 |
142 |
731 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
500 mg/kg |
50 |
148 |
148 |
730 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
500 mg/kg |
50 |
149 |
149 |
732 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
1000 mg/kg |
50 |
177 |
177 |
451 |
1 |
Cardiomyopathy |
Minimal |
Dosing Accident |
Cardiovascular System |
Heart |
|
1000 mg/kg |
50 |
199 |
199 |
522 |
1 |
Cardiomyopathy |
Minimal |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
1000 mg/kg |
50 |
164 |
164 |
653 |
1 |
Cardiomyopathy |
Minimal |
Natural Death |
Cardiovascular System |
Heart |
|
1000 mg/kg |
50 |
200 |
200 |
704 |
1 |
Cardiomyopathy |
Minimal |
Natural Death |
Cardiovascular System |
Heart |
|
1000 mg/kg |
50 |
153 |
153 |
732 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
1000 mg/kg |
50 |
159 |
159 |
731 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
1000 mg/kg |
50 |
162 |
162 |
730 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
1000 mg/kg |
50 |
184 |
184 |
732 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
1000 mg/kg |
50 |
194 |
194 |
424 |
1 |
Inflammation |
Mild |
Natural Death |
Cardiovascular System |
Heart |
|
250 mg/kg |
50 |
51 |
51 |
602 |
1 |
Mineralization |
Minimal |
Natural Death |
Cardiovascular System |
Heart |
|
250 mg/kg |
50 |
60 |
60 |
598 |
1 |
Mineralization |
Minimal |
Natural Death |
Cardiovascular System |
Heart |
|
1000 mg/kg |
50 |
169 |
169 |
537 |
1 |
Mineralization |
Minimal |
Natural Death |
Cardiovascular System |
Heart |
|
Vehicle Control |
50 |
43 |
43 |
661 |
1 |
Necrosis |
Minimal |
Natural Death |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
50 |
48 |
48 |
640 |
1 |
Amyloid Deposition |
Mild |
Moribund Sacrifice |
Endocrine System |
Adrenal Cortex |
|
1000 mg/kg |
50 |
199 |
199 |
522 |
1 |
Amyloid Deposition |
Minimal |
Moribund Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
50 |
20 |
20 |
732 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
50 |
25 |
25 |
731 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
50 |
39 |
39 |
731 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
250 mg/kg |
50 |
75 |
75 |
708 |
1 |
Hyperplasia |
Moderate |
Moribund Sacrifice |
Endocrine System |
Adrenal Cortex |
|
250 mg/kg |
50 |
94 |
94 |
687 |
1 |
Hyperplasia |
Marked |
Moribund Sacrifice |
Endocrine System |
Adrenal Cortex |
|
500 mg/kg |
50 |
130 |
130 |
731 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
1000 mg/kg |
50 |
184 |
184 |
732 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
50 |
15 |
15 |
644 |
1 |
Hypertrophy |
Mild |
Moribund Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
50 |
5 |
5 |
731 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
250 mg/kg |
50 |
79 |
79 |
731 |
1 |
Vacuolization Cytoplasmic |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Medulla |
|
Vehicle Control |
50 |
11 |
11 |
731 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Medulla |
|
250 mg/kg |
50 |
88 |
88 |
714 |
1 |
Hyperplasia |
Marked |
Moribund Sacrifice |
Endocrine System |
Adrenal Medulla |
|
500 mg/kg |
50 |
147 |
147 |
668 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Endocrine System |
Adrenal Medulla |
|
500 mg/kg |
50 |
116 |
116 |
722 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Endocrine System |
Adrenal Medulla |
|
1000 mg/kg |
50 |
156 |
156 |
585 |
1 |
Hyperplasia |
Marked |
Moribund Sacrifice |
Endocrine System |
Islets |
Pancreatic |
Vehicle Control |
50 |
35 |
35 |
730 |
1 |
Angiectasis |
Mild |
Terminal Sacrifice |
Endocrine System |
Islets |
Pancreatic |
Vehicle Control |
50 |
1 |
1 |
730 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Endocrine System |
Islets |
Pancreatic |
250 mg/kg |
50 |
76 |
76 |
608 |
1 |
Hyperplasia |
Moderate |
Natural Death |
Endocrine System |
Islets |
Pancreatic |
250 mg/kg |
50 |
83 |
83 |
730 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
Follicle |
250 mg/kg |
50 |
94 |
94 |
687 |
1 |
Cyst |
|
Moribund Sacrifice |
Endocrine System |
Thyroid Gland |
Follicle |
500 mg/kg |
50 |
101 |
101 |
731 |
1 |
Cyst |
|
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
|
1000 mg/kg |
50 |
199 |
199 |
522 |
1 |
Fibrosis |
Mild |
Moribund Sacrifice |
Endocrine System |
Thyroid Gland |
|
Vehicle Control |
50 |
36 |
36 |
730 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
General Body System |
Peritoneum |
|
250 mg/kg |
2 |
55 |
55 |
664 |
1 |
Inflammation |
Moderate, Suppurative |
Natural Death |
Genital System |
Coagulating Gland |
|
250 mg/kg |
4 |
83 |
83 |
730 |
1 |
Inflammation |
Marked, Chronic Active |
Terminal Sacrifice |
Genital System |
Coagulating Gland |
|
500 mg/kg |
1 |
119 |
119 |
613 |
1 |
Inflammation |
Marked |
Moribund Sacrifice |
Genital System |
Epididymis |
|
Vehicle Control |
50 |
5 |
5 |
731 |
1 |
Degeneration |
Minimal |
Terminal Sacrifice |
Genital System |
Epididymis |
|
500 mg/kg |
50 |
138 |
138 |
731 |
1 |
Granuloma Sperm |
Mild |
Terminal Sacrifice |
Genital System |
Epididymis |
|
250 mg/kg |
50 |
83 |
83 |
730 |
1 |
Inflammation |
Mild, Chronic Active |
Terminal Sacrifice |
Genital System |
Preputial Gland |
|
500 mg/kg |
50 |
106 |
106 |
513 |
1 |
Atrophy |
Moderate |
Natural Death |
Genital System |
Preputial Gland |
|
Vehicle Control |
50 |
10 |
10 |
673 |
1 |
Ectasia |
Moderate |
Natural Death |
Genital System |
Preputial Gland |
|
Vehicle Control |
50 |
9 |
9 |
731 |
1 |
Ectasia |
Moderate |
Terminal Sacrifice |
Genital System |
Preputial Gland |
|
250 mg/kg |
50 |
71 |
71 |
589 |
1 |
Ectasia |
Marked |
Natural Death |
Genital System |
Preputial Gland |
|
250 mg/kg |
50 |
93 |
93 |
657 |
1 |
Ectasia |
Moderate |
Natural Death |
Genital System |
Preputial Gland |
|
500 mg/kg |
50 |
111 |
111 |
577 |
1 |
Ectasia |
Marked |
Natural Death |
Genital System |
Preputial Gland |
|
1000 mg/kg |
50 |
155 |
155 |
609 |
1 |
Ectasia |
Marked |
Natural Death |
Genital System |
Preputial Gland |
|
1000 mg/kg |
50 |
164 |
164 |
653 |
1 |
Ectasia |
Moderate |
Natural Death |
Genital System |
Preputial Gland |
|
1000 mg/kg |
50 |
174 |
174 |
543 |
1 |
Ectasia |
Moderate |
Natural Death |
Genital System |
Preputial Gland |
|
1000 mg/kg |
50 |
189 |
189 |
661 |
1 |
Ectasia |
Moderate |
Natural Death |
Genital System |
Preputial Gland |
|
1000 mg/kg |
50 |
198 |
198 |
340 |
1 |
Ectasia |
Moderate |
Natural Death |
Genital System |
Preputial Gland |
|
Vehicle Control |
50 |
48 |
48 |
640 |
1 |
Inflammation |
Mild |
Moribund Sacrifice |
Genital System |
Preputial Gland |
|
Vehicle Control |
50 |
49 |
49 |
732 |
1 |
Inflammation |
Moderate |
Terminal Sacrifice |
Genital System |
Preputial Gland |
|
Vehicle Control |
50 |
7 |
7 |
732 |
1 |
Inflammation |
Marked |
Terminal Sacrifice |
Genital System |
Preputial Gland |
|
250 mg/kg |
50 |
100 |
100 |
713 |
1 |
Inflammation |
Moderate |
Natural Death |
Genital System |
Preputial Gland |
|
250 mg/kg |
50 |
87 |
87 |
673 |
1 |
Inflammation |
Moderate |
Natural Death |
Genital System |
Preputial Gland |
|
500 mg/kg |
50 |
104 |
104 |
731 |
1 |
Inflammation |
Moderate |
Terminal Sacrifice |
Genital System |
Preputial Gland |
|
500 mg/kg |
50 |
112 |
112 |
732 |
1 |
Inflammation |
Mild |
Terminal Sacrifice |
Genital System |
Preputial Gland |
|
500 mg/kg |
50 |
132 |
132 |
731 |
1 |
Inflammation |
Marked |
Terminal Sacrifice |
Genital System |
Preputial Gland |
|
1000 mg/kg |
50 |
167 |
167 |
688 |
1 |
Inflammation |
Mild |
Moribund Sacrifice |
Genital System |
Preputial Gland |
|
1000 mg/kg |
50 |
169 |
169 |
537 |
1 |
Inflammation |
Moderate |
Natural Death |
Genital System |
Preputial Gland |
|
1000 mg/kg |
50 |
188 |
188 |
616 |
1 |
Inflammation |
Mild |
Natural Death |
Genital System |
Preputial Gland |
|
1000 mg/kg |
50 |
197 |
197 |
547 |
1 |
Inflammation |
Moderate |
Natural Death |
Genital System |
Prostate |
Epithelium |
Vehicle Control |
50 |
1 |
1 |
730 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Genital System |
Prostate |
|
Vehicle Control |
50 |
35 |
35 |
730 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Genital System |
Prostate |
|
500 mg/kg |
50 |
142 |
142 |
731 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Genital System |
Prostate |
|
250 mg/kg |
50 |
51 |
51 |
602 |
1 |
Inflammation |
Mild |
Natural Death |
Genital System |
Prostate |
|
250 mg/kg |
50 |
55 |
55 |
664 |
1 |
Inflammation |
Moderate |
Natural Death |
Genital System |
Prostate |
|
250 mg/kg |
50 |
83 |
83 |
730 |
1 |
Inflammation |
Marked, Chronic Active |
Terminal Sacrifice |
Genital System |
Prostate |
|
500 mg/kg |
50 |
147 |
147 |
668 |
1 |
Inflammation |
Moderate |
Moribund Sacrifice |
Genital System |
Prostate |
|
1000 mg/kg |
50 |
199 |
199 |
522 |
1 |
Inflammation |
Moderate |
Moribund Sacrifice |
Genital System |
Seminal Vesicle |
|
1000 mg/kg |
50 |
199 |
199 |
522 |
1 |
Inflammation |
Moderate |
Moribund Sacrifice |
Genital System |
Testes |
Germinal Epith |
Vehicle Control |
50 |
16 |
16 |
631 |
1 |
Degeneration |
Minimal |
Natural Death |
Genital System |
Testes |
Germinal Epith |
Vehicle Control |
50 |
17 |
17 |
731 |
1 |
Degeneration |
Minimal |
Terminal Sacrifice |
Genital System |
Testes |
Germinal Epith |
Vehicle Control |
50 |
21 |
21 |
732 |
1 |
Degeneration |
Mild |
Terminal Sacrifice |
Genital System |
Testes |
Germinal Epith |
Vehicle Control |
50 |
37 |
37 |
732 |
1 |
Degeneration |
Mild |
Terminal Sacrifice |
Genital System |
Testes |
Germinal Epith |
Vehicle Control |
50 |
7 |
7 |
732 |
1 |
Degeneration |
Minimal |
Terminal Sacrifice |
Genital System |
Testes |
Germinal Epith |
250 mg/kg |
50 |
98 |
98 |
613 |
1 |
Degeneration |
Moderate |
Natural Death |
Genital System |
Testes |
Germinal Epith |
250 mg/kg |
50 |
56 |
56 |
732 |
1 |
Degeneration |
Mild |
Terminal Sacrifice |
Genital System |
Testes |
Germinal Epith |
250 mg/kg |
50 |
96 |
96 |
732 |
1 |
Degeneration |
Moderate |
Terminal Sacrifice |
Genital System |
Testes |
Germinal Epith |
500 mg/kg |
50 |
119 |
119 |
613 |
1 |
Degeneration |
Mild |
Moribund Sacrifice |
Genital System |
Testes |
Germinal Epith |
500 mg/kg |
50 |
123 |
123 |
674 |
1 |
Degeneration |
Moderate |
Moribund Sacrifice |
Genital System |
Testes |
Germinal Epith |
500 mg/kg |
50 |
147 |
147 |
668 |
1 |
Degeneration |
Mild |
Moribund Sacrifice |
Genital System |
Testes |
Germinal Epith |
500 mg/kg |
50 |
115 |
115 |
730 |
1 |
Degeneration |
Minimal |
Terminal Sacrifice |
Genital System |
Testes |
Germinal Epith |
500 mg/kg |
50 |
121 |
121 |
732 |
1 |
Degeneration |
Minimal |
Terminal Sacrifice |
Genital System |
Testes |
Germinal Epith |
1000 mg/kg |
50 |
165 |
165 |
511 |
1 |
Degeneration |
Minimal |
Moribund Sacrifice |
Genital System |
Testes |
Germinal Epith |
1000 mg/kg |
50 |
167 |
167 |
688 |
1 |
Degeneration |
Mild |
Moribund Sacrifice |
Genital System |
Testes |
Germinal Epith |
1000 mg/kg |
50 |
190 |
190 |
528 |
1 |
Degeneration |
Mild |
Moribund Sacrifice |
Genital System |
Testes |
Interstit Cell |
250 mg/kg |
50 |
84 |
84 |
732 |
1 |
Hyperplasia |
Marked |
Terminal Sacrifice |
Hematopoietic System |
Bone Marrow |
|
500 mg/kg |
50 |
128 |
128 |
540 |
1 |
Atrophy |
Minimal |
Moribund Sacrifice |
Hematopoietic System |
Bone Marrow |
|
1000 mg/kg |
50 |
171 |
171 |
385 |
1 |
Atrophy |
Mild |
Natural Death |
Hematopoietic System |
Bone Marrow |
|
Vehicle Control |
50 |
48 |
48 |
640 |
1 |
Hyperplasia |
Moderate |
Moribund Sacrifice |
Hematopoietic System |
Bone Marrow |
|
250 mg/kg |
50 |
55 |
55 |
664 |
1 |
Hyperplasia |
Marked |
Natural Death |
Hematopoietic System |
Bone Marrow |
|
500 mg/kg |
50 |
147 |
147 |
668 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Hematopoietic System |
Bone Marrow |
|
1000 mg/kg |
50 |
156 |
156 |
585 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Hematopoietic System |
Bone Marrow |
|
1000 mg/kg |
50 |
199 |
199 |
522 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
Vehicle Control |
50 |
38 |
38 |
732 |
1 |
Hyperplasia |
Moderate, Lymphoid |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
1000 mg/kg |
50 |
191 |
191 |
667 |
1 |
Atrophy |
Moderate |
Moribund Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
Vehicle Control |
50 |
21 |
21 |
732 |
1 |
Hemorrhage |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
250 mg/kg |
50 |
93 |
93 |
657 |
1 |
Hemorrhage |
Marked |
Natural Death |
Hematopoietic System |
Lymph Node |
Mesenteric |
Vehicle Control |
50 |
38 |
38 |
732 |
1 |
Hyperplasia |
Moderate, Lymphoid |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
250 mg/kg |
50 |
75 |
75 |
708 |
1 |
Hyperplasia |
Moderate, Lymphoid |
Moribund Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
500 mg/kg |
50 |
116 |
116 |
722 |
1 |
Hyperplasia |
Mild, Lymphoid |
Natural Death |
Hematopoietic System |
Lymph Node |
Mesenteric |
500 mg/kg |
50 |
145 |
145 |
522 |
1 |
Hyperplasia |
Moderate, Lymphoid |
Natural Death |
Hematopoietic System |
Lymph Node |
Mesenteric |
500 mg/kg |
50 |
103 |
103 |
731 |
1 |
Hyperplasia |
Mild, Lymphoid |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
500 mg/kg |
50 |
117 |
117 |
731 |
1 |
Hyperplasia |
Moderate, Lymphoid |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
1000 mg/kg |
50 |
166 |
166 |
730 |
1 |
Hyperplasia |
Moderate, Lymphoid |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
1000 mg/kg |
50 |
183 |
183 |
731 |
1 |
Hyperplasia |
Mild, Lymphoid |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
500 mg/kg |
50 |
106 |
106 |
513 |
1 |
Infiltration Cellular |
Mild, Histiocyte |
Natural Death |
Hematopoietic System |
Lymph Node |
Mesenteric |
500 mg/kg |
50 |
114 |
114 |
535 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Natural Death |
Hematopoietic System |
Lymph Node |
Mesenteric |
250 mg/kg |
50 |
66 |
66 |
535 |
1 |
Inflammation |
Moderate |
Moribund Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
1000 mg/kg |
50 |
167 |
167 |
688 |
1 |
Inflammation |
Moderate |
Moribund Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
1000 mg/kg |
50 |
191 |
191 |
667 |
1 |
Inflammation |
Mild |
Moribund Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
250 mg/kg |
50 |
66 |
66 |
535 |
1 |
Necrosis |
Marked |
Moribund Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
1000 mg/kg |
50 |
167 |
167 |
688 |
1 |
Necrosis |
Mild, Lymphoid |
Moribund Sacrifice |
Hematopoietic System |
Spleen |
Lymph Follic |
Vehicle Control |
50 |
10 |
10 |
673 |
1 |
Atrophy |
Moderate |
Natural Death |
Hematopoietic System |
Spleen |
Lymph Follic |
Vehicle Control |
50 |
26 |
26 |
640 |
1 |
Atrophy |
Moderate |
Natural Death |
Hematopoietic System |
Spleen |
Lymph Follic |
Vehicle Control |
50 |
43 |
43 |
661 |
1 |
Atrophy |
Mild |
Natural Death |
Hematopoietic System |
Spleen |
Lymph Follic |
250 mg/kg |
50 |
69 |
69 |
729 |
1 |
Atrophy |
Mild |
Moribund Sacrifice |
Hematopoietic System |
Spleen |
Lymph Follic |
250 mg/kg |
50 |
98 |
98 |
613 |
1 |
Atrophy |
Mild |
Natural Death |
Hematopoietic System |
Spleen |
Lymph Follic |
500 mg/kg |
50 |
128 |
128 |
540 |
1 |
Atrophy |
Moderate |
Moribund Sacrifice |
Hematopoietic System |
Spleen |
Lymph Follic |
1000 mg/kg |
50 |
190 |
190 |
528 |
1 |
Atrophy |
Mild |
Moribund Sacrifice |
Hematopoietic System |
Spleen |
Lymph Follic |
1000 mg/kg |
50 |
191 |
191 |
667 |
1 |
Atrophy |
Mild |
Moribund Sacrifice |
Hematopoietic System |
Spleen |
Lymph Follic |
1000 mg/kg |
50 |
154 |
154 |
686 |
1 |
Atrophy |
Mild |
Natural Death |
Hematopoietic System |
Spleen |
Lymph Follic |
1000 mg/kg |
50 |
155 |
155 |
609 |
1 |
Atrophy |
Mild |
Natural Death |
Hematopoietic System |
Spleen |
Lymph Follic |
1000 mg/kg |
50 |
194 |
194 |
424 |
1 |
Atrophy |
Mild |
Natural Death |
Hematopoietic System |
Spleen |
Lymph Follic |
1000 mg/kg |
50 |
197 |
197 |
547 |
1 |
Atrophy |
Mild |
Natural Death |
Hematopoietic System |
Spleen |
|
Vehicle Control |
50 |
48 |
48 |
640 |
1 |
Amyloid Deposition |
Mild |
Moribund Sacrifice |
Hematopoietic System |
Spleen |
|
1000 mg/kg |
50 |
199 |
199 |
522 |
1 |
Amyloid Deposition |
Marked |
Moribund Sacrifice |
Hematopoietic System |
Spleen |
|
1000 mg/kg |
50 |
170 |
170 |
633 |
1 |
Angiectasis |
Mild |
Moribund Sacrifice |
Hematopoietic System |
Spleen |
|
1000 mg/kg |
50 |
170 |
170 |
633 |
1 |
Fibrosis |
Mild |
Moribund Sacrifice |
Hematopoietic System |
Spleen |
|
Vehicle Control |
50 |
42 |
42 |
619 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Natural Death |
Hematopoietic System |
Spleen |
|
250 mg/kg |
50 |
81 |
81 |
700 |
1 |
Hematopoietic Cell Proliferation |
Moderate |
Moribund Sacrifice |
Hematopoietic System |
Spleen |
|
250 mg/kg |
50 |
85 |
85 |
426 |
1 |
Hematopoietic Cell Proliferation |
Moderate |
Natural Death |
Hematopoietic System |
Spleen |
|
250 mg/kg |
50 |
67 |
67 |
731 |
1 |
Hematopoietic Cell Proliferation |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
1000 mg/kg |
50 |
156 |
156 |
585 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Moribund Sacrifice |
Hematopoietic System |
Spleen |
|
1000 mg/kg |
50 |
167 |
167 |
688 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Moribund Sacrifice |
Hematopoietic System |
Spleen |
|
1000 mg/kg |
50 |
185 |
185 |
594 |
1 |
Hematopoietic Cell Proliferation |
Moderate |
Moribund Sacrifice |
Hematopoietic System |
Spleen |
|
1000 mg/kg |
50 |
191 |
191 |
667 |
1 |
Hematopoietic Cell Proliferation |
Mild |
Moribund Sacrifice |
Hematopoietic System |
Spleen |
|
1000 mg/kg |
50 |
169 |
169 |
537 |
1 |
Hematopoietic Cell Proliferation |
Moderate |
Natural Death |
Hematopoietic System |
Spleen |
|
250 mg/kg |
50 |
78 |
78 |
732 |
1 |
Hyperplasia |
Moderate, Lymphoid |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
1000 mg/kg |
50 |
163 |
163 |
718 |
1 |
Hyperplasia |
Mild, Lymphoid |
Natural Death |
Hematopoietic System |
Spleen |
|
1000 mg/kg |
50 |
166 |
166 |
730 |
1 |
Hyperplasia |
Moderate, Lymphoid |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
|
250 mg/kg |
50 |
75 |
75 |
708 |
1 |
Pigmentation |
Moderate, Hemosiderin |
Moribund Sacrifice |
Hematopoietic System |
Spleen |
|
250 mg/kg |
50 |
94 |
94 |
687 |
1 |
Pigmentation |
Marked, Hemosiderin |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
Epithel Cell |
250 mg/kg |
50 |
58 |
58 |
732 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
Vehicle Control |
50 |
14 |
14 |
501 |
1 |
Atrophy |
Mild |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
Vehicle Control |
50 |
15 |
15 |
644 |
1 |
Atrophy |
Marked |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
Vehicle Control |
50 |
18 |
18 |
714 |
1 |
Atrophy |
Moderate |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
Vehicle Control |
50 |
23 |
23 |
555 |
1 |
Atrophy |
Mild |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
Vehicle Control |
50 |
24 |
24 |
595 |
1 |
Atrophy |
Mild |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
Vehicle Control |
50 |
34 |
34 |
645 |
1 |
Atrophy |
Marked |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
Vehicle Control |
50 |
40 |
40 |
730 |
1 |
Atrophy |
Marked |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
Vehicle Control |
50 |
48 |
48 |
640 |
1 |
Atrophy |
Marked |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
Vehicle Control |
50 |
10 |
10 |
673 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Thymus |
|
Vehicle Control |
50 |
13 |
13 |
683 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Thymus |
|
Vehicle Control |
50 |
16 |
16 |
631 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Thymus |
|
Vehicle Control |
50 |
26 |
26 |
640 |
1 |
Atrophy |
Moderate |
Natural Death |
Hematopoietic System |
Thymus |
|
Vehicle Control |
50 |
41 |
41 |
699 |
1 |
Atrophy |
Moderate |
Natural Death |
Hematopoietic System |
Thymus |
|
Vehicle Control |
50 |
42 |
42 |
619 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Thymus |
|
Vehicle Control |
50 |
50 |
50 |
374 |
1 |
Atrophy |
Moderate |
Natural Death |
Hematopoietic System |
Thymus |
|
Vehicle Control |
50 |
1 |
1 |
730 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
Vehicle Control |
50 |
17 |
17 |
731 |
1 |
Atrophy |
Marked |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
Vehicle Control |
50 |
19 |
19 |
731 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
Vehicle Control |
50 |
2 |
2 |
731 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
Vehicle Control |
50 |
20 |
20 |
732 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
Vehicle Control |
50 |
25 |
25 |
731 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
Vehicle Control |
50 |
27 |
27 |
732 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
Vehicle Control |
50 |
28 |
28 |
731 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
Vehicle Control |
50 |
29 |
29 |
731 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
Vehicle Control |
50 |
3 |
3 |
730 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
Vehicle Control |
50 |
31 |
31 |
730 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
Vehicle Control |
50 |
32 |
32 |
731 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
Vehicle Control |
50 |
33 |
33 |
731 |
1 |
Atrophy |
Marked |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
Vehicle Control |
50 |
35 |
35 |
730 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
Vehicle Control |
50 |
36 |
36 |
730 |
1 |
Atrophy |
Marked |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
Vehicle Control |
50 |
38 |
38 |
732 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
Vehicle Control |
50 |
39 |
39 |
731 |
1 |
Atrophy |
Marked |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
Vehicle Control |
50 |
4 |
4 |
732 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
Vehicle Control |
50 |
44 |
44 |
732 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
Vehicle Control |
50 |
45 |
45 |
732 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
Vehicle Control |
50 |
46 |
46 |
730 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
Vehicle Control |
50 |
47 |
47 |
730 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
Vehicle Control |
50 |
49 |
49 |
732 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
Vehicle Control |
50 |
5 |
5 |
731 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
Vehicle Control |
50 |
7 |
7 |
732 |
1 |
Atrophy |
Marked |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
Vehicle Control |
50 |
9 |
9 |
731 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
250 mg/kg |
50 |
57 |
57 |
665 |
1 |
Atrophy |
Marked |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
250 mg/kg |
50 |
66 |
66 |
535 |
1 |
Atrophy |
Marked |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
250 mg/kg |
50 |
69 |
69 |
729 |
1 |
Atrophy |
Marked |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
250 mg/kg |
50 |
70 |
70 |
613 |
1 |
Atrophy |
Moderate |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
250 mg/kg |
50 |
75 |
75 |
708 |
1 |
Atrophy |
Marked |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
250 mg/kg |
50 |
81 |
81 |
700 |
1 |
Atrophy |
Moderate |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
250 mg/kg |
50 |
88 |
88 |
714 |
1 |
Atrophy |
Marked |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
250 mg/kg |
50 |
99 |
99 |
713 |
1 |
Atrophy |
Marked |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
250 mg/kg |
50 |
100 |
100 |
713 |
1 |
Atrophy |
Moderate |
Natural Death |
Hematopoietic System |
Thymus |
|
250 mg/kg |
50 |
55 |
55 |
664 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Thymus |
|
250 mg/kg |
50 |
59 |
59 |
403 |
1 |
Atrophy |
Minimal |
Natural Death |
Hematopoietic System |
Thymus |
|
250 mg/kg |
50 |
62 |
62 |
633 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Thymus |
|
250 mg/kg |
50 |
71 |
71 |
589 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Thymus |
|
250 mg/kg |
50 |
76 |
76 |
608 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Thymus |
|
250 mg/kg |
50 |
85 |
85 |
426 |
1 |
Atrophy |
Minimal |
Natural Death |
Hematopoietic System |
Thymus |
|
250 mg/kg |
50 |
87 |
87 |
673 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Thymus |
|
250 mg/kg |
50 |
93 |
93 |
657 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Thymus |
|
250 mg/kg |
50 |
98 |
98 |
613 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Thymus |
|
250 mg/kg |
50 |
52 |
52 |
732 |
1 |
Atrophy |
Marked |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
250 mg/kg |
50 |
53 |
53 |
731 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
250 mg/kg |
50 |
56 |
56 |
732 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
250 mg/kg |
50 |
58 |
58 |
732 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
250 mg/kg |
50 |
61 |
61 |
732 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
250 mg/kg |
50 |
63 |
63 |
732 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
250 mg/kg |
50 |
64 |
64 |
730 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
250 mg/kg |
50 |
67 |
67 |
731 |
1 |
Atrophy |
Marked |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
250 mg/kg |
50 |
68 |
68 |
732 |
1 |
Atrophy |
Marked |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
250 mg/kg |
50 |
72 |
72 |
731 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
250 mg/kg |
50 |
77 |
77 |
732 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
250 mg/kg |
50 |
78 |
78 |
732 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
250 mg/kg |
50 |
79 |
79 |
731 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
250 mg/kg |
50 |
80 |
80 |
732 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
250 mg/kg |
50 |
82 |
82 |
730 |
1 |
Atrophy |
Marked |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
250 mg/kg |
50 |
83 |
83 |
730 |
1 |
Atrophy |
Marked |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
250 mg/kg |
50 |
84 |
84 |
732 |
1 |
Atrophy |
Marked |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
250 mg/kg |
50 |
86 |
86 |
732 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
250 mg/kg |
50 |
89 |
89 |
732 |
1 |
Atrophy |
Marked |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
250 mg/kg |
50 |
90 |
90 |
732 |
1 |
Atrophy |
Marked |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
250 mg/kg |
50 |
91 |
91 |
730 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
250 mg/kg |
50 |
92 |
92 |
731 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
250 mg/kg |
50 |
95 |
95 |
732 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
250 mg/kg |
50 |
96 |
96 |
732 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
500 mg/kg |
50 |
102 |
102 |
568 |
1 |
Atrophy |
Marked |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
500 mg/kg |
50 |
123 |
123 |
674 |
1 |
Atrophy |
Marked |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
500 mg/kg |
50 |
128 |
128 |
540 |
1 |
Atrophy |
Marked |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
500 mg/kg |
50 |
106 |
106 |
513 |
1 |
Atrophy |
Moderate |
Natural Death |
Hematopoietic System |
Thymus |
|
500 mg/kg |
50 |
111 |
111 |
577 |
1 |
Atrophy |
Mild |
Natural Death |
Hematopoietic System |
Thymus |
|
500 mg/kg |
50 |
114 |
114 |
535 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Thymus |
|
500 mg/kg |
50 |
116 |
116 |
722 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Thymus |
|
500 mg/kg |
50 |
145 |
145 |
522 |
1 |
Atrophy |
Mild |
Natural Death |
Hematopoietic System |
Thymus |
|
500 mg/kg |
50 |
101 |
101 |
731 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
500 mg/kg |
50 |
103 |
103 |
731 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
500 mg/kg |
50 |
104 |
104 |
731 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
500 mg/kg |
50 |
105 |
105 |
731 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
500 mg/kg |
50 |
107 |
107 |
731 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
500 mg/kg |
50 |
108 |
108 |
731 |
1 |
Atrophy |
Marked |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
500 mg/kg |
50 |
110 |
110 |
731 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
500 mg/kg |
50 |
117 |
117 |
731 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
500 mg/kg |
50 |
118 |
118 |
731 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
500 mg/kg |
50 |
120 |
120 |
731 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
500 mg/kg |
50 |
121 |
121 |
732 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
500 mg/kg |
50 |
124 |
124 |
731 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
500 mg/kg |
50 |
125 |
125 |
732 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
500 mg/kg |
50 |
126 |
126 |
732 |
1 |
Atrophy |
Marked |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
500 mg/kg |
50 |
129 |
129 |
732 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
500 mg/kg |
50 |
130 |
130 |
731 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
500 mg/kg |
50 |
131 |
131 |
732 |
1 |
Atrophy |
Marked |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
500 mg/kg |
50 |
132 |
132 |
731 |
1 |
Atrophy |
Marked |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
500 mg/kg |
50 |
133 |
133 |
730 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
500 mg/kg |
50 |
134 |
134 |
732 |
1 |
Atrophy |
Marked |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
500 mg/kg |
50 |
135 |
135 |
732 |
1 |
Atrophy |
Marked |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
500 mg/kg |
50 |
136 |
136 |
730 |
1 |
Atrophy |
Marked |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
500 mg/kg |
50 |
137 |
137 |
731 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
500 mg/kg |
50 |
138 |
138 |
731 |
1 |
Atrophy |
Marked |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
500 mg/kg |
50 |
140 |
140 |
732 |
1 |
Atrophy |
Marked |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
500 mg/kg |
50 |
142 |
142 |
731 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
500 mg/kg |
50 |
143 |
143 |
732 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
500 mg/kg |
50 |
144 |
144 |
732 |
1 |
Atrophy |
Marked |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
500 mg/kg |
50 |
146 |
146 |
730 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
500 mg/kg |
50 |
148 |
148 |
730 |
1 |
Atrophy |
Marked |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
500 mg/kg |
50 |
149 |
149 |
732 |
1 |
Atrophy |
Marked |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
500 mg/kg |
50 |
150 |
150 |
731 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
1000 mg/kg |
50 |
177 |
177 |
451 |
1 |
Atrophy |
Marked |
Dosing Accident |
Hematopoietic System |
Thymus |
|
1000 mg/kg |
50 |
156 |
156 |
585 |
1 |
Atrophy |
Moderate |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
1000 mg/kg |
50 |
167 |
167 |
688 |
1 |
Atrophy |
Marked |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
1000 mg/kg |
50 |
168 |
168 |
502 |
1 |
Atrophy |
Moderate |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
1000 mg/kg |
50 |
178 |
178 |
613 |
1 |
Atrophy |
Marked |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
1000 mg/kg |
50 |
180 |
180 |
213 |
1 |
Atrophy |
Mild |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
1000 mg/kg |
50 |
190 |
190 |
528 |
1 |
Atrophy |
Moderate |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
1000 mg/kg |
50 |
191 |
191 |
667 |
1 |
Atrophy |
Marked |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
1000 mg/kg |
50 |
199 |
199 |
522 |
1 |
Atrophy |
Marked |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
1000 mg/kg |
50 |
154 |
154 |
686 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Thymus |
|
1000 mg/kg |
50 |
155 |
155 |
609 |
1 |
Atrophy |
Moderate |
Natural Death |
Hematopoietic System |
Thymus |
|
1000 mg/kg |
50 |
158 |
158 |
686 |
1 |
Atrophy |
Moderate |
Natural Death |
Hematopoietic System |
Thymus |
|
1000 mg/kg |
50 |
163 |
163 |
718 |
1 |
Atrophy |
Moderate |
Natural Death |
Hematopoietic System |
Thymus |
|
1000 mg/kg |
50 |
164 |
164 |
653 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Thymus |
|
1000 mg/kg |
50 |
169 |
169 |
537 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Thymus |
|
1000 mg/kg |
50 |
171 |
171 |
385 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Thymus |
|
1000 mg/kg |
50 |
173 |
173 |
411 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Thymus |
|
1000 mg/kg |
50 |
175 |
175 |
465 |
1 |
Atrophy |
Moderate |
Natural Death |
Hematopoietic System |
Thymus |
|
1000 mg/kg |
50 |
179 |
179 |
233 |
1 |
Atrophy |
Mild |
Natural Death |
Hematopoietic System |
Thymus |
|
1000 mg/kg |
50 |
182 |
182 |
548 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Thymus |
|
1000 mg/kg |
50 |
187 |
187 |
704 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Thymus |
|
1000 mg/kg |
50 |
189 |
189 |
661 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Thymus |
|
1000 mg/kg |
50 |
192 |
192 |
130 |
1 |
Atrophy |
Moderate |
Natural Death |
Hematopoietic System |
Thymus |
|
1000 mg/kg |
50 |
193 |
193 |
484 |
1 |
Atrophy |
Moderate |
Natural Death |
Hematopoietic System |
Thymus |
|
1000 mg/kg |
50 |
195 |
195 |
408 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Thymus |
|
1000 mg/kg |
50 |
196 |
196 |
459 |
1 |
Atrophy |
Mild |
Natural Death |
Hematopoietic System |
Thymus |
|
1000 mg/kg |
50 |
197 |
197 |
547 |
1 |
Atrophy |
Moderate |
Natural Death |
Hematopoietic System |
Thymus |
|
1000 mg/kg |
50 |
198 |
198 |
340 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Thymus |
|
1000 mg/kg |
50 |
200 |
200 |
704 |
1 |
Atrophy |
Mild |
Natural Death |
Hematopoietic System |
Thymus |
|
1000 mg/kg |
50 |
151 |
151 |
731 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
1000 mg/kg |
50 |
153 |
153 |
732 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
1000 mg/kg |
50 |
159 |
159 |
731 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
1000 mg/kg |
50 |
161 |
161 |
731 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
1000 mg/kg |
50 |
162 |
162 |
730 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
1000 mg/kg |
50 |
166 |
166 |
730 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
1000 mg/kg |
50 |
176 |
176 |
730 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
1000 mg/kg |
50 |
181 |
181 |
731 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
1000 mg/kg |
50 |
183 |
183 |
731 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
1000 mg/kg |
50 |
184 |
184 |
732 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
1000 mg/kg |
50 |
186 |
186 |
730 |
1 |
Atrophy |
Marked |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
Vehicle Control |
50 |
3 |
3 |
730 |
1 |
Cyst |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
Vehicle Control |
50 |
22 |
22 |
732 |
1 |
Hyperplasia |
Minimal, Lymphoid |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
250 mg/kg |
50 |
75 |
75 |
708 |
1 |
Thrombosis |
Mild |
Moribund Sacrifice |
Integumentary System |
Skin |
Subcut Tiss |
250 mg/kg |
50 |
83 |
83 |
730 |
1 |
Necrosis |
Marked |
Terminal Sacrifice |
Integumentary System |
Skin |
|
500 mg/kg |
50 |
104 |
104 |
731 |
1 |
Inflammation |
Marked |
Terminal Sacrifice |
Integumentary System |
Skin |
|
Vehicle Control |
50 |
17 |
17 |
731 |
1 |
Ulcer |
Marked |
Terminal Sacrifice |
Integumentary System |
Skin |
|
Vehicle Control |
50 |
3 |
3 |
730 |
1 |
Ulcer |
Moderate |
Terminal Sacrifice |
Integumentary System |
Skin |
|
250 mg/kg |
50 |
57 |
57 |
665 |
1 |
Ulcer |
Marked |
Moribund Sacrifice |
Integumentary System |
Skin |
|
250 mg/kg |
50 |
73 |
73 |
697 |
1 |
Ulcer |
Marked |
Moribund Sacrifice |
Integumentary System |
Skin |
|
250 mg/kg |
50 |
81 |
81 |
700 |
1 |
Ulcer |
Marked |
Moribund Sacrifice |
Integumentary System |
Skin |
|
250 mg/kg |
50 |
52 |
52 |
732 |
1 |
Ulcer |
Marked |
Terminal Sacrifice |
Integumentary System |
Skin |
|
500 mg/kg |
50 |
102 |
102 |
568 |
1 |
Ulcer |
Marked |
Moribund Sacrifice |
Integumentary System |
Skin |
|
500 mg/kg |
50 |
119 |
119 |
613 |
1 |
Ulcer |
Marked |
Moribund Sacrifice |
Integumentary System |
Skin |
|
500 mg/kg |
50 |
147 |
147 |
668 |
1 |
Ulcer |
Marked |
Moribund Sacrifice |
Integumentary System |
Skin |
|
1000 mg/kg |
50 |
156 |
156 |
585 |
1 |
Ulcer |
Marked |
Moribund Sacrifice |
Integumentary System |
Skin |
|
1000 mg/kg |
50 |
158 |
158 |
686 |
1 |
Ulcer |
Mild |
Natural Death |
Integumentary System |
Skin |
|
1000 mg/kg |
50 |
169 |
169 |
537 |
1 |
Ulcer |
Mild |
Natural Death |
Integumentary System |
Skin |
|
1000 mg/kg |
50 |
197 |
197 |
547 |
1 |
Ulcer |
Marked |
Natural Death |
Musculoskeletal System |
Bone |
Femur |
250 mg/kg |
50 |
75 |
75 |
708 |
1 |
Callus |
Minimal |
Moribund Sacrifice |
Musculoskeletal System |
Bone |
Femur |
250 mg/kg |
50 |
59 |
59 |
403 |
1 |
Callus |
Mild |
Natural Death |
Musculoskeletal System |
Bone |
Joint |
1000 mg/kg |
50 |
154 |
154 |
686 |
1 |
Degeneration |
Moderate |
Natural Death |
Musculoskeletal System |
Bone |
Joint |
1000 mg/kg |
50 |
173 |
173 |
411 |
1 |
Degeneration |
Mild |
Natural Death |
Musculoskeletal System |
Bone |
Joint |
1000 mg/kg |
50 |
187 |
187 |
704 |
1 |
Degeneration |
Minimal |
Natural Death |
Musculoskeletal System |
Bone |
Joint |
1000 mg/kg |
50 |
200 |
200 |
704 |
1 |
Degeneration |
Mild |
Natural Death |
Musculoskeletal System |
Bone |
Vertebra |
500 mg/kg |
50 |
144 |
144 |
732 |
1 |
Fracture |
|
Terminal Sacrifice |
Musculoskeletal System |
Bone |
|
Vehicle Control |
50 |
11 |
11 |
731 |
1 |
Fibro-Osseous Lesion |
|
Terminal Sacrifice |
Musculoskeletal System |
Bone |
|
1000 mg/kg |
50 |
185 |
185 |
594 |
1 |
Fibro-Osseous Lesion |
|
Moribund Sacrifice |
Musculoskeletal System |
Bone |
|
1000 mg/kg |
50 |
166 |
166 |
730 |
1 |
Fibrosis |
Minimal |
Terminal Sacrifice |
Musculoskeletal System |
Bone |
|
Vehicle Control |
50 |
48 |
48 |
640 |
1 |
Fibrous Osteodystrophy |
Mild |
Moribund Sacrifice |
Nervous System |
Brain |
|
250 mg/kg |
50 |
85 |
85 |
426 |
1 |
Inflammation |
Minimal, Suppurative |
Natural Death |
Nervous System |
Peripheral Nerve |
Axon, Sciatic |
1000 mg/kg |
2 |
190 |
190 |
528 |
1 |
Degeneration |
Moderate |
Moribund Sacrifice |
Nervous System |
Spinal Cord |
Axon |
1000 mg/kg |
2 |
165 |
165 |
511 |
1 |
Degeneration |
Moderate |
Moribund Sacrifice |
Nervous System |
Spinal Cord |
Axon |
1000 mg/kg |
2 |
190 |
190 |
528 |
1 |
Degeneration |
Mild |
Moribund Sacrifice |
Respiratory System |
Lung |
Alveolar Epith |
Vehicle Control |
50 |
15 |
15 |
644 |
1 |
Hyperplasia |
Moderate |
Moribund Sacrifice |
Respiratory System |
Lung |
Alveolar Epith |
Vehicle Control |
50 |
11 |
11 |
731 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolar Epith |
Vehicle Control |
50 |
2 |
2 |
731 |
1 |
Hyperplasia |
Marked |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolar Epith |
Vehicle Control |
50 |
22 |
22 |
732 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolar Epith |
Vehicle Control |
50 |
32 |
32 |
731 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolar Epith |
250 mg/kg |
50 |
96 |
96 |
732 |
1 |
Hyperplasia |
Marked |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolar Epith |
500 mg/kg |
50 |
113 |
113 |
731 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolar Epith |
500 mg/kg |
50 |
133 |
133 |
730 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolar Epith |
500 mg/kg |
50 |
138 |
138 |
731 |
1 |
Hyperplasia |
Moderate |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolar Epith |
500 mg/kg |
50 |
141 |
141 |
731 |
1 |
Hyperplasia |
Marked |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolar Epith |
500 mg/kg |
50 |
142 |
142 |
731 |
1 |
Hyperplasia |
Marked |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolar Epith |
500 mg/kg |
50 |
143 |
143 |
732 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolar Epith |
1000 mg/kg |
50 |
170 |
170 |
633 |
1 |
Hyperplasia |
Marked |
Moribund Sacrifice |
Respiratory System |
Lung |
Alveolar Epith |
1000 mg/kg |
50 |
153 |
153 |
732 |
1 |
Hyperplasia |
Marked |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolar Epith |
Vehicle Control |
50 |
40 |
40 |
730 |
1 |
Hypertrophy |
Minimal |
Moribund Sacrifice |
Respiratory System |
Lung |
Alveolar Epith |
Vehicle Control |
50 |
3 |
3 |
730 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolar Epith |
500 mg/kg |
50 |
107 |
107 |
731 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolar Epith |
1000 mg/kg |
50 |
163 |
163 |
718 |
1 |
Hypertrophy |
Mild |
Natural Death |
Respiratory System |
Lung |
Arteriole |
500 mg/kg |
50 |
132 |
132 |
731 |
1 |
Thrombosis |
Minimal |
Terminal Sacrifice |
Respiratory System |
Lung |
Bronchiole |
250 mg/kg |
50 |
90 |
90 |
732 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Respiratory System |
Lung |
Interstitium |
250 mg/kg |
50 |
75 |
75 |
708 |
1 |
Fibrosis |
Minimal |
Moribund Sacrifice |
Respiratory System |
Lung |
|
Vehicle Control |
50 |
50 |
50 |
374 |
1 |
Hemorrhage |
Moderate |
Natural Death |
Respiratory System |
Lung |
|
Vehicle Control |
50 |
34 |
34 |
645 |
1 |
Infiltration Cellular |
Marked, Histiocyte |
Moribund Sacrifice |
Respiratory System |
Lung |
|
500 mg/kg |
50 |
123 |
123 |
674 |
1 |
Infiltration Cellular |
Moderate, Histiocyte |
Moribund Sacrifice |
Respiratory System |
Lung |
|
Vehicle Control |
50 |
48 |
48 |
640 |
1 |
Inflammation |
Mild |
Moribund Sacrifice |
Respiratory System |
Lung |
|
1000 mg/kg |
50 |
177 |
177 |
451 |
1 |
Inflammation |
Marked |
Dosing Accident |
Respiratory System |
Lung |
|
1000 mg/kg |
50 |
194 |
194 |
424 |
1 |
Inflammation |
Moderate |
Natural Death |
Respiratory System |
Lung |
|
500 mg/kg |
50 |
123 |
123 |
674 |
1 |
Pigmentation |
Minimal, Hemosiderin |
Moribund Sacrifice |
Respiratory System |
Lung |
|
Vehicle Control |
50 |
48 |
48 |
640 |
1 |
Thrombosis |
Mild |
Moribund Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
Vehicle Control |
50 |
14 |
14 |
501 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
Vehicle Control |
50 |
15 |
15 |
644 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
Vehicle Control |
50 |
18 |
18 |
714 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
Vehicle Control |
50 |
34 |
34 |
645 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
Vehicle Control |
50 |
40 |
40 |
730 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
Vehicle Control |
50 |
48 |
48 |
640 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
Vehicle Control |
50 |
10 |
10 |
673 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Respiratory System |
Nose |
Respirat Epith |
Vehicle Control |
50 |
16 |
16 |
631 |
1 |
Hyperplasia |
Mild |
Natural Death |
Respiratory System |
Nose |
Respirat Epith |
Vehicle Control |
50 |
26 |
26 |
640 |
1 |
Hyperplasia |
Mild |
Natural Death |
Respiratory System |
Nose |
Respirat Epith |
Vehicle Control |
50 |
42 |
42 |
619 |
1 |
Hyperplasia |
Mild |
Natural Death |
Respiratory System |
Nose |
Respirat Epith |
Vehicle Control |
50 |
1 |
1 |
730 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
Vehicle Control |
50 |
2 |
2 |
731 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
Vehicle Control |
50 |
21 |
21 |
732 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
Vehicle Control |
50 |
25 |
25 |
731 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
Vehicle Control |
50 |
27 |
27 |
732 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
Vehicle Control |
50 |
30 |
30 |
732 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
Vehicle Control |
50 |
31 |
31 |
730 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
Vehicle Control |
50 |
33 |
33 |
731 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
Vehicle Control |
50 |
35 |
35 |
730 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
Vehicle Control |
50 |
37 |
37 |
732 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
Vehicle Control |
50 |
38 |
38 |
732 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
Vehicle Control |
50 |
39 |
39 |
731 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
Vehicle Control |
50 |
4 |
4 |
732 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
Vehicle Control |
50 |
46 |
46 |
730 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
Vehicle Control |
50 |
47 |
47 |
730 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
Vehicle Control |
50 |
5 |
5 |
731 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
Vehicle Control |
50 |
7 |
7 |
732 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
250 mg/kg |
50 |
66 |
66 |
535 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
250 mg/kg |
50 |
70 |
70 |
613 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
250 mg/kg |
50 |
75 |
75 |
708 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
250 mg/kg |
50 |
88 |
88 |
714 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
250 mg/kg |
50 |
94 |
94 |
687 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
250 mg/kg |
50 |
99 |
99 |
713 |
1 |
Hyperplasia |
Mild |
Moribund Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
250 mg/kg |
50 |
100 |
100 |
713 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Respiratory System |
Nose |
Respirat Epith |
250 mg/kg |
50 |
55 |
55 |
664 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Respiratory System |
Nose |
Respirat Epith |
250 mg/kg |
50 |
93 |
93 |
657 |
1 |
Hyperplasia |
Mild |
Natural Death |
Respiratory System |
Nose |
Respirat Epith |
250 mg/kg |
50 |
97 |
97 |
470 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Respiratory System |
Nose |
Respirat Epith |
250 mg/kg |
50 |
98 |
98 |
613 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Respiratory System |
Nose |
Respirat Epith |
250 mg/kg |
50 |
56 |
56 |
732 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
250 mg/kg |
50 |
61 |
61 |
732 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
250 mg/kg |
50 |
63 |
63 |
732 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
250 mg/kg |
50 |
64 |
64 |
730 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
250 mg/kg |
50 |
67 |
67 |
731 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
250 mg/kg |
50 |
72 |
72 |
731 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
250 mg/kg |
50 |
78 |
78 |
732 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
250 mg/kg |
50 |
80 |
80 |
732 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
250 mg/kg |
50 |
83 |
83 |
730 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
250 mg/kg |
50 |
84 |
84 |
732 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
250 mg/kg |
50 |
89 |
89 |
732 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
250 mg/kg |
50 |
90 |
90 |
732 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
250 mg/kg |
50 |
91 |
91 |
730 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
250 mg/kg |
50 |
96 |
96 |
732 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
500 mg/kg |
50 |
114 |
114 |
535 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Respiratory System |
Nose |
Respirat Epith |
500 mg/kg |
50 |
103 |
103 |
731 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
500 mg/kg |
50 |
104 |
104 |
731 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
500 mg/kg |
50 |
105 |
105 |
731 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
500 mg/kg |
50 |
107 |
107 |
731 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
500 mg/kg |
50 |
108 |
108 |
731 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
500 mg/kg |
50 |
113 |
113 |
731 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
500 mg/kg |
50 |
120 |
120 |
731 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
500 mg/kg |
50 |
121 |
121 |
732 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
500 mg/kg |
50 |
122 |
122 |
730 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
500 mg/kg |
50 |
129 |
129 |
732 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
500 mg/kg |
50 |
130 |
130 |
731 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
500 mg/kg |
50 |
136 |
136 |
730 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
500 mg/kg |
50 |
137 |
137 |
731 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
500 mg/kg |
50 |
138 |
138 |
731 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
500 mg/kg |
50 |
139 |
139 |
732 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
500 mg/kg |
50 |
141 |
141 |
731 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
500 mg/kg |
50 |
142 |
142 |
731 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
500 mg/kg |
50 |
144 |
144 |
732 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
500 mg/kg |
50 |
146 |
146 |
730 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
1000 mg/kg |
50 |
165 |
165 |
511 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
1000 mg/kg |
50 |
167 |
167 |
688 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
1000 mg/kg |
50 |
190 |
190 |
528 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
1000 mg/kg |
50 |
191 |
191 |
667 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
1000 mg/kg |
50 |
199 |
199 |
522 |
1 |
Hyperplasia |
Minimal |
Moribund Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
1000 mg/kg |
50 |
154 |
154 |
686 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Respiratory System |
Nose |
Respirat Epith |
1000 mg/kg |
50 |
189 |
189 |
661 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Respiratory System |
Nose |
Respirat Epith |
1000 mg/kg |
50 |
194 |
194 |
424 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Respiratory System |
Nose |
Respirat Epith |
1000 mg/kg |
50 |
159 |
159 |
731 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
1000 mg/kg |
50 |
176 |
176 |
730 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
1000 mg/kg |
50 |
183 |
183 |
731 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
1000 mg/kg |
50 |
186 |
186 |
730 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
500 mg/kg |
50 |
111 |
111 |
577 |
1 |
Necrosis |
Minimal |
Natural Death |
Respiratory System |
Nose |
|
Vehicle Control |
50 |
12 |
12 |
448 |
1 |
Inflammation |
Mild |
Moribund Sacrifice |
Respiratory System |
Nose |
|
Vehicle Control |
50 |
18 |
18 |
714 |
1 |
Inflammation |
Mild |
Moribund Sacrifice |
Respiratory System |
Nose |
|
Vehicle Control |
50 |
34 |
34 |
645 |
1 |
Inflammation |
Mild |
Moribund Sacrifice |
Respiratory System |
Nose |
|
Vehicle Control |
50 |
43 |
43 |
661 |
1 |
Inflammation |
Moderate |
Natural Death |
Respiratory System |
Nose |
|
Vehicle Control |
50 |
7 |
7 |
732 |
1 |
Inflammation |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
|
250 mg/kg |
50 |
93 |
93 |
657 |
1 |
Inflammation |
Mild |
Natural Death |
Respiratory System |
Nose |
|
250 mg/kg |
50 |
72 |
72 |
731 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
|
500 mg/kg |
50 |
119 |
119 |
613 |
1 |
Inflammation |
Minimal |
Moribund Sacrifice |
Respiratory System |
Nose |
|
500 mg/kg |
50 |
128 |
128 |
540 |
1 |
Inflammation |
Minimal |
Moribund Sacrifice |
Respiratory System |
Nose |
|
500 mg/kg |
50 |
136 |
136 |
730 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
|
1000 mg/kg |
50 |
174 |
174 |
543 |
1 |
Inflammation |
Minimal |
Natural Death |
Respiratory System |
Nose |
|
1000 mg/kg |
50 |
197 |
197 |
547 |
1 |
Inflammation |
Minimal |
Natural Death |
Respiratory System |
Nose |
|
250 mg/kg |
50 |
65 |
65 |
693 |
1 |
Polyp, Inflammatory |
Moderate |
Moribund Sacrifice |
Special Senses System |
Eye |
Cornea |
Vehicle Control |
50 |
40 |
40 |
730 |
1 |
Inflammation |
Minimal |
Moribund Sacrifice |
Special Senses System |
Eye |
Cornea |
250 mg/kg |
50 |
95 |
95 |
732 |
1 |
Inflammation |
Mild |
Terminal Sacrifice |
Special Senses System |
Eye |
Cornea |
500 mg/kg |
50 |
138 |
138 |
731 |
1 |
Inflammation |
Moderate |
Terminal Sacrifice |
Special Senses System |
Eye |
|
250 mg/kg |
50 |
75 |
75 |
708 |
1 |
Atrophy |
Marked |
Moribund Sacrifice |
Special Senses System |
Eye |
|
500 mg/kg |
50 |
146 |
146 |
730 |
1 |
Atrophy |
Marked |
Terminal Sacrifice |
Special Senses System |
Eye |
|
Vehicle Control |
50 |
10 |
10 |
673 |
1 |
Cataract |
Mild |
Natural Death |
Special Senses System |
Eye |
|
Vehicle Control |
50 |
41 |
41 |
699 |
1 |
Cataract |
Minimal |
Natural Death |
Special Senses System |
Eye |
|
500 mg/kg |
50 |
109 |
109 |
731 |
1 |
Cataract |
Minimal |
Terminal Sacrifice |
Special Senses System |
Eye |
|
1000 mg/kg |
50 |
171 |
171 |
385 |
1 |
Cataract |
Mild |
Natural Death |
Special Senses System |
Eye |
|
Vehicle Control |
50 |
23 |
23 |
555 |
1 |
Inflammation |
Marked |
Moribund Sacrifice |
Special Senses System |
Eye |
|
1000 mg/kg |
50 |
157 |
157 |
511 |
1 |
Inflammation |
Moderate |
Moribund Sacrifice |
Special Senses System |
Harderian Gland |
|
Vehicle Control |
50 |
17 |
17 |
731 |
1 |
Fibrosis |
Minimal |
Terminal Sacrifice |
Special Senses System |
Harderian Gland |
|
Vehicle Control |
50 |
2 |
2 |
731 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Special Senses System |
Harderian Gland |
|
250 mg/kg |
50 |
88 |
88 |
714 |
1 |
Hyperplasia |
Marked |
Moribund Sacrifice |
Special Senses System |
Harderian Gland |
|
1000 mg/kg |
50 |
176 |
176 |
730 |
1 |
Hyperplasia |
Marked |
Terminal Sacrifice |
Urinary System |
Kidney |
Glomerulus |
Vehicle Control |
50 |
48 |
48 |
640 |
1 |
Amyloid Deposition |
Marked |
Moribund Sacrifice |
Urinary System |
Kidney |
Glomerulus |
1000 mg/kg |
50 |
199 |
199 |
522 |
1 |
Amyloid Deposition |
Mild |
Moribund Sacrifice |
Urinary System |
Kidney |
Papilla |
500 mg/kg |
50 |
117 |
117 |
731 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
Papilla |
Vehicle Control |
50 |
24 |
24 |
595 |
1 |
Necrosis |
Minimal |
Moribund Sacrifice |
Urinary System |
Kidney |
Papilla |
Vehicle Control |
50 |
47 |
47 |
730 |
1 |
Necrosis |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
Papilla |
Vehicle Control |
50 |
49 |
49 |
732 |
1 |
Necrosis |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
Papilla |
250 mg/kg |
50 |
92 |
92 |
731 |
1 |
Necrosis |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
Pelvis |
500 mg/kg |
50 |
147 |
147 |
668 |
1 |
Inflammation |
Moderate |
Moribund Sacrifice |
Urinary System |
Kidney |
Pelvis |
1000 mg/kg |
50 |
199 |
199 |
522 |
1 |
Inflammation |
Mild |
Moribund Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
Vehicle Control |
50 |
18 |
18 |
714 |
1 |
Cyst |
|
Moribund Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
Vehicle Control |
50 |
13 |
13 |
683 |
1 |
Cyst |
|
Natural Death |
Urinary System |
Kidney |
Renal Tubule |
Vehicle Control |
50 |
1 |
1 |
730 |
1 |
Cyst |
|
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
Vehicle Control |
50 |
29 |
29 |
731 |
1 |
Cyst |
|
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
Vehicle Control |
50 |
3 |
3 |
730 |
1 |
Cyst |
|
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
Vehicle Control |
50 |
36 |
36 |
730 |
1 |
Cyst |
|
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
250 mg/kg |
50 |
65 |
65 |
693 |
1 |
Cyst |
|
Moribund Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
250 mg/kg |
50 |
96 |
96 |
732 |
1 |
Cyst |
|
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
500 mg/kg |
50 |
105 |
105 |
731 |
1 |
Cyst |
|
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
500 mg/kg |
50 |
117 |
117 |
731 |
1 |
Cyst |
|
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
500 mg/kg |
50 |
125 |
125 |
732 |
1 |
Cyst |
|
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
500 mg/kg |
50 |
137 |
137 |
731 |
1 |
Cyst |
|
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
500 mg/kg |
50 |
150 |
150 |
731 |
1 |
Cyst |
|
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
1000 mg/kg |
50 |
157 |
157 |
511 |
1 |
Cyst |
|
Moribund Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
1000 mg/kg |
50 |
199 |
199 |
522 |
1 |
Cyst |
|
Moribund Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
1000 mg/kg |
50 |
161 |
161 |
731 |
1 |
Cyst |
|
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
1000 mg/kg |
50 |
172 |
172 |
730 |
1 |
Cyst |
|
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
1000 mg/kg |
50 |
176 |
176 |
730 |
1 |
Cyst |
|
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
1000 mg/kg |
50 |
181 |
181 |
731 |
Multiple |
Cyst |
|
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
1000 mg/kg |
50 |
186 |
186 |
730 |
1 |
Cyst |
|
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
250 mg/kg |
50 |
70 |
70 |
613 |
1 |
Cytoplasmic Alteration |
Minimal |
Moribund Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
250 mg/kg |
50 |
73 |
73 |
697 |
1 |
Cytoplasmic Alteration |
Mild |
Moribund Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
250 mg/kg |
50 |
94 |
94 |
687 |
1 |
Cytoplasmic Alteration |
Minimal |
Moribund Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
250 mg/kg |
50 |
99 |
99 |
713 |
1 |
Cytoplasmic Alteration |
Mild |
Moribund Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
250 mg/kg |
50 |
100 |
100 |
713 |
1 |
Cytoplasmic Alteration |
Mild |
Natural Death |
Urinary System |
Kidney |
Renal Tubule |
250 mg/kg |
50 |
51 |
51 |
602 |
1 |
Cytoplasmic Alteration |
Moderate |
Natural Death |
Urinary System |
Kidney |
Renal Tubule |
250 mg/kg |
50 |
55 |
55 |
664 |
1 |
Cytoplasmic Alteration |
Moderate |
Natural Death |
Urinary System |
Kidney |
Renal Tubule |
250 mg/kg |
50 |
71 |
71 |
589 |
1 |
Cytoplasmic Alteration |
Minimal |
Natural Death |
Urinary System |
Kidney |
Renal Tubule |
250 mg/kg |
50 |
87 |
87 |
673 |
1 |
Cytoplasmic Alteration |
Mild |
Natural Death |
Urinary System |
Kidney |
Renal Tubule |
250 mg/kg |
50 |
93 |
93 |
657 |
1 |
Cytoplasmic Alteration |
Mild |
Natural Death |
Urinary System |
Kidney |
Renal Tubule |
250 mg/kg |
50 |
98 |
98 |
613 |
1 |
Cytoplasmic Alteration |
Mild |
Natural Death |
Urinary System |
Kidney |
Renal Tubule |
250 mg/kg |
50 |
52 |
52 |
732 |
1 |
Cytoplasmic Alteration |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
250 mg/kg |
50 |
53 |
53 |
731 |
1 |
Cytoplasmic Alteration |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
250 mg/kg |
50 |
56 |
56 |
732 |
1 |
Cytoplasmic Alteration |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
250 mg/kg |
50 |
58 |
58 |
732 |
1 |
Cytoplasmic Alteration |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
250 mg/kg |
50 |
67 |
67 |
731 |
1 |
Cytoplasmic Alteration |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
250 mg/kg |
50 |
74 |
74 |
732 |
1 |
Cytoplasmic Alteration |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
250 mg/kg |
50 |
79 |
79 |
731 |
1 |
Cytoplasmic Alteration |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
250 mg/kg |
50 |
92 |
92 |
731 |
1 |
Cytoplasmic Alteration |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
250 mg/kg |
50 |
95 |
95 |
732 |
1 |
Cytoplasmic Alteration |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
500 mg/kg |
50 |
102 |
102 |
568 |
1 |
Cytoplasmic Alteration |
Moderate |
Moribund Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
500 mg/kg |
50 |
119 |
119 |
613 |
1 |
Cytoplasmic Alteration |
Mild |
Moribund Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
500 mg/kg |
50 |
123 |
123 |
674 |
1 |
Cytoplasmic Alteration |
Moderate |
Moribund Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
500 mg/kg |
50 |
127 |
127 |
714 |
1 |
Cytoplasmic Alteration |
Mild |
Moribund Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
500 mg/kg |
50 |
128 |
128 |
540 |
1 |
Cytoplasmic Alteration |
Moderate |
Moribund Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
500 mg/kg |
50 |
147 |
147 |
668 |
1 |
Cytoplasmic Alteration |
Moderate |
Moribund Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
500 mg/kg |
50 |
106 |
106 |
513 |
1 |
Cytoplasmic Alteration |
Moderate |
Natural Death |
Urinary System |
Kidney |
Renal Tubule |
500 mg/kg |
50 |
111 |
111 |
577 |
1 |
Cytoplasmic Alteration |
Mild |
Natural Death |
Urinary System |
Kidney |
Renal Tubule |
500 mg/kg |
50 |
114 |
114 |
535 |
1 |
Cytoplasmic Alteration |
Moderate |
Natural Death |
Urinary System |
Kidney |
Renal Tubule |
500 mg/kg |
50 |
116 |
116 |
722 |
1 |
Cytoplasmic Alteration |
Moderate |
Natural Death |
Urinary System |
Kidney |
Renal Tubule |
500 mg/kg |
50 |
145 |
145 |
522 |
1 |
Cytoplasmic Alteration |
Moderate |
Natural Death |
Urinary System |
Kidney |
Renal Tubule |
500 mg/kg |
50 |
101 |
101 |
731 |
1 |
Cytoplasmic Alteration |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
500 mg/kg |
50 |
103 |
103 |
731 |
1 |
Cytoplasmic Alteration |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
500 mg/kg |
50 |
104 |
104 |
731 |
1 |
Cytoplasmic Alteration |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
500 mg/kg |
50 |
105 |
105 |
731 |
1 |
Cytoplasmic Alteration |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
500 mg/kg |
50 |
107 |
107 |
731 |
1 |
Cytoplasmic Alteration |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
500 mg/kg |
50 |
108 |
108 |
731 |
1 |
Cytoplasmic Alteration |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
500 mg/kg |
50 |
110 |
110 |
731 |
1 |
Cytoplasmic Alteration |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
500 mg/kg |
50 |
112 |
112 |
732 |
1 |
Cytoplasmic Alteration |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
500 mg/kg |
50 |
113 |
113 |
731 |
1 |
Cytoplasmic Alteration |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
500 mg/kg |
50 |
115 |
115 |
730 |
1 |
Cytoplasmic Alteration |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
500 mg/kg |
50 |
117 |
117 |
731 |
1 |
Cytoplasmic Alteration |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
500 mg/kg |
50 |
118 |
118 |
731 |
1 |
Cytoplasmic Alteration |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
500 mg/kg |
50 |
120 |
120 |
731 |
1 |
Cytoplasmic Alteration |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
500 mg/kg |
50 |
121 |
121 |
732 |
1 |
Cytoplasmic Alteration |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
500 mg/kg |
50 |
122 |
122 |
730 |
1 |
Cytoplasmic Alteration |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
500 mg/kg |
50 |
124 |
124 |
731 |
1 |
Cytoplasmic Alteration |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
500 mg/kg |
50 |
125 |
125 |
732 |
1 |
Cytoplasmic Alteration |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
500 mg/kg |
50 |
126 |
126 |
732 |
1 |
Cytoplasmic Alteration |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
500 mg/kg |
50 |
129 |
129 |
732 |
1 |
Cytoplasmic Alteration |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
500 mg/kg |
50 |
130 |
130 |
731 |
1 |
Cytoplasmic Alteration |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
500 mg/kg |
50 |
131 |
131 |
732 |
1 |
Cytoplasmic Alteration |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
500 mg/kg |
50 |
132 |
132 |
731 |
1 |
Cytoplasmic Alteration |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
500 mg/kg |
50 |
133 |
133 |
730 |
1 |
Cytoplasmic Alteration |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
500 mg/kg |
50 |
134 |
134 |
732 |
1 |
Cytoplasmic Alteration |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
500 mg/kg |
50 |
135 |
135 |
732 |
1 |
Cytoplasmic Alteration |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
500 mg/kg |
50 |
136 |
136 |
730 |
1 |
Cytoplasmic Alteration |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
500 mg/kg |
50 |
137 |
137 |
731 |
1 |
Cytoplasmic Alteration |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
500 mg/kg |
50 |
139 |
139 |
732 |
1 |
Cytoplasmic Alteration |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
500 mg/kg |
50 |
140 |
140 |
732 |
1 |
Cytoplasmic Alteration |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
500 mg/kg |
50 |
141 |
141 |
731 |
1 |
Cytoplasmic Alteration |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
500 mg/kg |
50 |
142 |
142 |
731 |
1 |
Cytoplasmic Alteration |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
500 mg/kg |
50 |
143 |
143 |
732 |
1 |
Cytoplasmic Alteration |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
500 mg/kg |
50 |
144 |
144 |
732 |
1 |
Cytoplasmic Alteration |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
500 mg/kg |
50 |
146 |
146 |
730 |
1 |
Cytoplasmic Alteration |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
500 mg/kg |
50 |
148 |
148 |
730 |
1 |
Cytoplasmic Alteration |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
500 mg/kg |
50 |
150 |
150 |
731 |
1 |
Cytoplasmic Alteration |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
1000 mg/kg |
50 |
177 |
177 |
451 |
1 |
Cytoplasmic Alteration |
Moderate |
Dosing Accident |
Urinary System |
Kidney |
Renal Tubule |
1000 mg/kg |
50 |
156 |
156 |
585 |
1 |
Cytoplasmic Alteration |
Mild |
Moribund Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
1000 mg/kg |
50 |
157 |
157 |
511 |
1 |
Cytoplasmic Alteration |
Moderate |
Moribund Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
1000 mg/kg |
50 |
165 |
165 |
511 |
1 |
Cytoplasmic Alteration |
Moderate |
Moribund Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
1000 mg/kg |
50 |
167 |
167 |
688 |
1 |
Cytoplasmic Alteration |
Moderate |
Moribund Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
1000 mg/kg |
50 |
168 |
168 |
502 |
1 |
Cytoplasmic Alteration |
Moderate |
Moribund Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
1000 mg/kg |
50 |
170 |
170 |
633 |
1 |
Cytoplasmic Alteration |
Moderate |
Moribund Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
1000 mg/kg |
50 |
178 |
178 |
613 |
1 |
Cytoplasmic Alteration |
Moderate |
Moribund Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
1000 mg/kg |
50 |
180 |
180 |
213 |
1 |
Cytoplasmic Alteration |
Moderate |
Moribund Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
1000 mg/kg |
50 |
185 |
185 |
594 |
1 |
Cytoplasmic Alteration |
Moderate |
Moribund Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
1000 mg/kg |
50 |
190 |
190 |
528 |
1 |
Cytoplasmic Alteration |
Moderate |
Moribund Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
1000 mg/kg |
50 |
191 |
191 |
667 |
1 |
Cytoplasmic Alteration |
Mild |
Moribund Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
1000 mg/kg |
50 |
199 |
199 |
522 |
1 |
Cytoplasmic Alteration |
Moderate |
Moribund Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
1000 mg/kg |
50 |
154 |
154 |
686 |
1 |
Cytoplasmic Alteration |
Minimal |
Natural Death |
Urinary System |
Kidney |
Renal Tubule |
1000 mg/kg |
50 |
158 |
158 |
686 |
1 |
Cytoplasmic Alteration |
Moderate |
Natural Death |
Urinary System |
Kidney |
Renal Tubule |
1000 mg/kg |
50 |
160 |
160 |
421 |
1 |
Cytoplasmic Alteration |
Moderate |
Natural Death |
Urinary System |
Kidney |
Renal Tubule |
1000 mg/kg |
50 |
163 |
163 |
718 |
1 |
Cytoplasmic Alteration |
Moderate |
Natural Death |
Urinary System |
Kidney |
Renal Tubule |
1000 mg/kg |
50 |
164 |
164 |
653 |
1 |
Cytoplasmic Alteration |
Mild |
Natural Death |
Urinary System |
Kidney |
Renal Tubule |
1000 mg/kg |
50 |
169 |
169 |
537 |
1 |
Cytoplasmic Alteration |
Moderate |
Natural Death |
Urinary System |
Kidney |
Renal Tubule |
1000 mg/kg |
50 |
173 |
173 |
411 |
1 |
Cytoplasmic Alteration |
Moderate |
Natural Death |
Urinary System |
Kidney |
Renal Tubule |
1000 mg/kg |
50 |
174 |
174 |
543 |
1 |
Cytoplasmic Alteration |
Moderate |
Natural Death |
Urinary System |
Kidney |
Renal Tubule |
1000 mg/kg |
50 |
175 |
175 |
465 |
1 |
Cytoplasmic Alteration |
Moderate |
Natural Death |
Urinary System |
Kidney |
Renal Tubule |
1000 mg/kg |
50 |
179 |
179 |
233 |
1 |
Cytoplasmic Alteration |
Mild |
Natural Death |
Urinary System |
Kidney |
Renal Tubule |
1000 mg/kg |
50 |
182 |
182 |
548 |
1 |
Cytoplasmic Alteration |
Mild |
Natural Death |
Urinary System |
Kidney |
Renal Tubule |
1000 mg/kg |
50 |
187 |
187 |
704 |
1 |
Cytoplasmic Alteration |
Moderate |
Natural Death |
Urinary System |
Kidney |
Renal Tubule |
1000 mg/kg |
50 |
189 |
189 |
661 |
1 |
Cytoplasmic Alteration |
Moderate |
Natural Death |
Urinary System |
Kidney |
Renal Tubule |
1000 mg/kg |
50 |
192 |
192 |
130 |
1 |
Cytoplasmic Alteration |
Moderate |
Natural Death |
Urinary System |
Kidney |
Renal Tubule |
1000 mg/kg |
50 |
193 |
193 |
484 |
1 |
Cytoplasmic Alteration |
Mild |
Natural Death |
Urinary System |
Kidney |
Renal Tubule |
1000 mg/kg |
50 |
194 |
194 |
424 |
1 |
Cytoplasmic Alteration |
Mild |
Natural Death |
Urinary System |
Kidney |
Renal Tubule |
1000 mg/kg |
50 |
195 |
195 |
408 |
1 |
Cytoplasmic Alteration |
Mild |
Natural Death |
Urinary System |
Kidney |
Renal Tubule |
1000 mg/kg |
50 |
196 |
196 |
459 |
1 |
Cytoplasmic Alteration |
Mild |
Natural Death |
Urinary System |
Kidney |
Renal Tubule |
1000 mg/kg |
50 |
197 |
197 |
547 |
1 |
Cytoplasmic Alteration |
Moderate |
Natural Death |
Urinary System |
Kidney |
Renal Tubule |
1000 mg/kg |
50 |
198 |
198 |
340 |
1 |
Cytoplasmic Alteration |
Moderate |
Natural Death |
Urinary System |
Kidney |
Renal Tubule |
1000 mg/kg |
50 |
200 |
200 |
704 |
1 |
Cytoplasmic Alteration |
Mild |
Natural Death |
Urinary System |
Kidney |
Renal Tubule |
1000 mg/kg |
50 |
151 |
151 |
731 |
1 |
Cytoplasmic Alteration |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
1000 mg/kg |
50 |
153 |
153 |
732 |
1 |
Cytoplasmic Alteration |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
1000 mg/kg |
50 |
159 |
159 |
731 |
1 |
Cytoplasmic Alteration |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
1000 mg/kg |
50 |
161 |
161 |
731 |
1 |
Cytoplasmic Alteration |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
1000 mg/kg |
50 |
162 |
162 |
730 |
1 |
Cytoplasmic Alteration |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
1000 mg/kg |
50 |
166 |
166 |
730 |
1 |
Cytoplasmic Alteration |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
1000 mg/kg |
50 |
172 |
172 |
730 |
1 |
Cytoplasmic Alteration |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
1000 mg/kg |
50 |
176 |
176 |
730 |
1 |
Cytoplasmic Alteration |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
1000 mg/kg |
50 |
181 |
181 |
731 |
1 |
Cytoplasmic Alteration |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
1000 mg/kg |
50 |
183 |
183 |
731 |
1 |
Cytoplasmic Alteration |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
1000 mg/kg |
50 |
184 |
184 |
732 |
1 |
Cytoplasmic Alteration |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
1000 mg/kg |
50 |
186 |
186 |
730 |
1 |
Cytoplasmic Alteration |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
1000 mg/kg |
50 |
164 |
164 |
653 |
1 |
Inflammation |
Mild |
Natural Death |
Urinary System |
Kidney |
Renal Tubule |
1000 mg/kg |
50 |
195 |
195 |
408 |
1 |
Inflammation |
Minimal |
Natural Death |
Urinary System |
Kidney |
Renal Tubule |
1000 mg/kg |
50 |
198 |
198 |
340 |
1 |
Inflammation |
Minimal |
Natural Death |
Urinary System |
Kidney |
Renal Tubule |
1000 mg/kg |
50 |
200 |
200 |
704 |
1 |
Inflammation |
Minimal |
Natural Death |
Urinary System |
Kidney |
Renal Tubule |
Vehicle Control |
50 |
14 |
14 |
501 |
1 |
Mineralization |
Moderate |
Moribund Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
500 mg/kg |
50 |
125 |
125 |
732 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
1000 mg/kg |
50 |
157 |
157 |
511 |
1 |
Mineralization |
Minimal |
Moribund Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
1000 mg/kg |
50 |
167 |
167 |
688 |
1 |
Mineralization |
Minimal |
Moribund Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
1000 mg/kg |
50 |
180 |
180 |
213 |
1 |
Necrosis |
Minimal |
Moribund Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
1000 mg/kg |
50 |
169 |
169 |
537 |
1 |
Necrosis |
Minimal |
Natural Death |
Urinary System |
Kidney |
Renal Tubule |
1000 mg/kg |
50 |
195 |
195 |
408 |
1 |
Necrosis |
Mild |
Natural Death |
Urinary System |
Kidney |
Renal Tubule |
1000 mg/kg |
50 |
198 |
198 |
340 |
1 |
Necrosis |
Moderate |
Natural Death |
Urinary System |
Kidney |
Renal Tubule |
250 mg/kg |
50 |
57 |
57 |
665 |
1 |
Pigmentation |
Moderate |
Moribund Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
250 mg/kg |
50 |
66 |
66 |
535 |
1 |
Pigmentation |
Mild |
Moribund Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
250 mg/kg |
50 |
100 |
100 |
713 |
1 |
Pigmentation |
Marked |
Natural Death |
Urinary System |
Kidney |
Renal Tubule |
250 mg/kg |
50 |
51 |
51 |
602 |
1 |
Pigmentation |
Mild |
Natural Death |
Urinary System |
Kidney |
Renal Tubule |
250 mg/kg |
50 |
79 |
79 |
731 |
1 |
Pigmentation |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
500 mg/kg |
50 |
132 |
132 |
731 |
1 |
Pigmentation |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
1000 mg/kg |
50 |
167 |
167 |
688 |
1 |
Pigmentation |
Moderate |
Moribund Sacrifice |
Urinary System |
Kidney |
Renal Tubule |
1000 mg/kg |
50 |
158 |
158 |
686 |
1 |
Pigmentation |
Moderate |
Natural Death |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
43 |
43 |
661 |
1 |
Cyst |
Minimal |
Natural Death |
Urinary System |
Kidney |
|
250 mg/kg |
50 |
94 |
94 |
687 |
1 |
Hydronephrosis |
Marked |
Moribund Sacrifice |
Urinary System |
Kidney |
|
250 mg/kg |
50 |
52 |
52 |
732 |
1 |
Hydronephrosis |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
|
250 mg/kg |
50 |
95 |
95 |
732 |
1 |
Hydronephrosis |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
|
1000 mg/kg |
50 |
172 |
172 |
730 |
1 |
Hydronephrosis |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
|
250 mg/kg |
50 |
72 |
72 |
731 |
1 |
Infarct |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
250 mg/kg |
50 |
56 |
56 |
732 |
1 |
Infiltration Cellular |
Moderate, Lymphocyte |
Terminal Sacrifice |
Urinary System |
Kidney |
|
500 mg/kg |
50 |
108 |
108 |
731 |
1 |
Infiltration Cellular |
Marked, Lymphocyte |
Terminal Sacrifice |
Urinary System |
Kidney |
|
500 mg/kg |
50 |
148 |
148 |
730 |
1 |
Infiltration Cellular |
Moderate, Lymphocyte |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
15 |
15 |
644 |
1 |
Nephropathy |
Minimal |
Moribund Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
18 |
18 |
714 |
1 |
Nephropathy |
Minimal |
Moribund Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
24 |
24 |
595 |
1 |
Nephropathy |
Minimal |
Moribund Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
34 |
34 |
645 |
1 |
Nephropathy |
Minimal |
Moribund Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
40 |
40 |
730 |
1 |
Nephropathy |
Minimal |
Moribund Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
48 |
48 |
640 |
1 |
Nephropathy |
Moderate |
Moribund Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
16 |
16 |
631 |
1 |
Nephropathy |
Minimal |
Natural Death |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
26 |
26 |
640 |
1 |
Nephropathy |
Minimal |
Natural Death |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
42 |
42 |
619 |
1 |
Nephropathy |
Minimal |
Natural Death |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
50 |
50 |
374 |
1 |
Nephropathy |
Mild |
Natural Death |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
1 |
1 |
730 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
11 |
11 |
731 |
1 |
Nephropathy |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
17 |
17 |
731 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
19 |
19 |
731 |
1 |
Nephropathy |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
2 |
2 |
731 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
20 |
20 |
732 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
21 |
21 |
732 |
1 |
Nephropathy |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
22 |
22 |
732 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
25 |
25 |
731 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
27 |
27 |
732 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
28 |
28 |
731 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
29 |
29 |
731 |
1 |
Nephropathy |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
3 |
3 |
730 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
30 |
30 |
732 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
31 |
31 |
730 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
32 |
32 |
731 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
33 |
33 |
731 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
35 |
35 |
730 |
1 |
Nephropathy |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
36 |
36 |
730 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
37 |
37 |
732 |
1 |
Nephropathy |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
38 |
38 |
732 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
39 |
39 |
731 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
4 |
4 |
732 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
44 |
44 |
732 |
1 |
Nephropathy |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
45 |
45 |
732 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
46 |
46 |
730 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
47 |
47 |
730 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
49 |
49 |
732 |
1 |
Nephropathy |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
5 |
5 |
731 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
7 |
7 |
732 |
1 |
Nephropathy |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
50 |
9 |
9 |
731 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
250 mg/kg |
50 |
66 |
66 |
535 |
1 |
Nephropathy |
Mild |
Moribund Sacrifice |
Urinary System |
Kidney |
|
250 mg/kg |
50 |
69 |
69 |
729 |
1 |
Nephropathy |
Moderate |
Moribund Sacrifice |
Urinary System |
Kidney |
|
250 mg/kg |
50 |
73 |
73 |
697 |
1 |
Nephropathy |
Moderate |
Moribund Sacrifice |
Urinary System |
Kidney |
|
250 mg/kg |
50 |
75 |
75 |
708 |
1 |
Nephropathy |
Minimal |
Moribund Sacrifice |
Urinary System |
Kidney |
|
250 mg/kg |
50 |
81 |
81 |
700 |
1 |
Nephropathy |
Minimal |
Moribund Sacrifice |
Urinary System |
Kidney |
|
250 mg/kg |
50 |
88 |
88 |
714 |
1 |
Nephropathy |
Minimal |
Moribund Sacrifice |
Urinary System |
Kidney |
|
250 mg/kg |
50 |
94 |
94 |
687 |
1 |
Nephropathy |
Marked |
Moribund Sacrifice |
Urinary System |
Kidney |
|
250 mg/kg |
50 |
99 |
99 |
713 |
1 |
Nephropathy |
Moderate |
Moribund Sacrifice |
Urinary System |
Kidney |
|
250 mg/kg |
50 |
100 |
100 |
713 |
1 |
Nephropathy |
Mild |
Natural Death |
Urinary System |
Kidney |
|
250 mg/kg |
50 |
55 |
55 |
664 |
1 |
Nephropathy |
Mild |
Natural Death |
Urinary System |
Kidney |
|
250 mg/kg |
50 |
62 |
62 |
633 |
1 |
Nephropathy |
Moderate |
Natural Death |
Urinary System |
Kidney |
|
250 mg/kg |
50 |
87 |
87 |
673 |
1 |
Nephropathy |
Minimal |
Natural Death |
Urinary System |
Kidney |
|
250 mg/kg |
50 |
93 |
93 |
657 |
1 |
Nephropathy |
Moderate |
Natural Death |
Urinary System |
Kidney |
|
250 mg/kg |
50 |
97 |
97 |
470 |
1 |
Nephropathy |
Minimal |
Natural Death |
Urinary System |
Kidney |
|
250 mg/kg |
50 |
52 |
52 |
732 |
1 |
Nephropathy |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
|
250 mg/kg |
50 |
53 |
53 |
731 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
250 mg/kg |
50 |
56 |
56 |
732 |
1 |
Nephropathy |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
|
250 mg/kg |
50 |
61 |
61 |
732 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
250 mg/kg |
50 |
67 |
67 |
731 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
250 mg/kg |
50 |
68 |
68 |
732 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
250 mg/kg |
50 |
72 |
72 |
731 |
1 |
Nephropathy |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
|
250 mg/kg |
50 |
74 |
74 |
732 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
250 mg/kg |
50 |
77 |
77 |
732 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
250 mg/kg |
50 |
82 |
82 |
730 |
1 |
Nephropathy |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
|
250 mg/kg |
50 |
83 |
83 |
730 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
250 mg/kg |
50 |
84 |
84 |
732 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
250 mg/kg |
50 |
89 |
89 |
732 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
250 mg/kg |
50 |
92 |
92 |
731 |
1 |
Nephropathy |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
|
250 mg/kg |
50 |
95 |
95 |
732 |
1 |
Nephropathy |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
|
250 mg/kg |
50 |
96 |
96 |
732 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
500 mg/kg |
50 |
102 |
102 |
568 |
1 |
Nephropathy |
Minimal |
Moribund Sacrifice |
Urinary System |
Kidney |
|
500 mg/kg |
50 |
123 |
123 |
674 |
1 |
Nephropathy |
Moderate |
Moribund Sacrifice |
Urinary System |
Kidney |
|
500 mg/kg |
50 |
147 |
147 |
668 |
1 |
Nephropathy |
Moderate |
Moribund Sacrifice |
Urinary System |
Kidney |
|
500 mg/kg |
50 |
106 |
106 |
513 |
1 |
Nephropathy |
Mild |
Natural Death |
Urinary System |
Kidney |
|
500 mg/kg |
50 |
114 |
114 |
535 |
1 |
Nephropathy |
Minimal |
Natural Death |
Urinary System |
Kidney |
|
500 mg/kg |
50 |
101 |
101 |
731 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
500 mg/kg |
50 |
104 |
104 |
731 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
500 mg/kg |
50 |
109 |
109 |
731 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
500 mg/kg |
50 |
110 |
110 |
731 |
1 |
Nephropathy |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
|
500 mg/kg |
50 |
113 |
113 |
731 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
500 mg/kg |
50 |
115 |
115 |
730 |
1 |
Nephropathy |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
|
500 mg/kg |
50 |
117 |
117 |
731 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
500 mg/kg |
50 |
118 |
118 |
731 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
500 mg/kg |
50 |
120 |
120 |
731 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
500 mg/kg |
50 |
121 |
121 |
732 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
500 mg/kg |
50 |
122 |
122 |
730 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
500 mg/kg |
50 |
124 |
124 |
731 |
1 |
Nephropathy |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
|
500 mg/kg |
50 |
125 |
125 |
732 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
500 mg/kg |
50 |
126 |
126 |
732 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
500 mg/kg |
50 |
129 |
129 |
732 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
500 mg/kg |
50 |
130 |
130 |
731 |
1 |
Nephropathy |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
|
500 mg/kg |
50 |
131 |
131 |
732 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
500 mg/kg |
50 |
132 |
132 |
731 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
500 mg/kg |
50 |
133 |
133 |
730 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
500 mg/kg |
50 |
134 |
134 |
732 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
500 mg/kg |
50 |
135 |
135 |
732 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
500 mg/kg |
50 |
137 |
137 |
731 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
500 mg/kg |
50 |
138 |
138 |
731 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
500 mg/kg |
50 |
139 |
139 |
732 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
500 mg/kg |
50 |
140 |
140 |
732 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
500 mg/kg |
50 |
142 |
142 |
731 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
500 mg/kg |
50 |
149 |
149 |
732 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
1000 mg/kg |
50 |
156 |
156 |
585 |
1 |
Nephropathy |
Mild |
Moribund Sacrifice |
Urinary System |
Kidney |
|
1000 mg/kg |
50 |
157 |
157 |
511 |
1 |
Nephropathy |
Mild |
Moribund Sacrifice |
Urinary System |
Kidney |
|
1000 mg/kg |
50 |
165 |
165 |
511 |
1 |
Nephropathy |
Mild |
Moribund Sacrifice |
Urinary System |
Kidney |
|
1000 mg/kg |
50 |
167 |
167 |
688 |
1 |
Nephropathy |
Moderate |
Moribund Sacrifice |
Urinary System |
Kidney |
|
1000 mg/kg |
50 |
168 |
168 |
502 |
1 |
Nephropathy |
Mild |
Moribund Sacrifice |
Urinary System |
Kidney |
|
1000 mg/kg |
50 |
170 |
170 |
633 |
1 |
Nephropathy |
Minimal |
Moribund Sacrifice |
Urinary System |
Kidney |
|
1000 mg/kg |
50 |
178 |
178 |
613 |
1 |
Nephropathy |
Minimal |
Moribund Sacrifice |
Urinary System |
Kidney |
|
1000 mg/kg |
50 |
180 |
180 |
213 |
1 |
Nephropathy |
Minimal |
Moribund Sacrifice |
Urinary System |
Kidney |
|
1000 mg/kg |
50 |
185 |
185 |
594 |
1 |
Nephropathy |
Mild |
Moribund Sacrifice |
Urinary System |
Kidney |
|
1000 mg/kg |
50 |
190 |
190 |
528 |
1 |
Nephropathy |
Minimal |
Moribund Sacrifice |
Urinary System |
Kidney |
|
1000 mg/kg |
50 |
191 |
191 |
667 |
1 |
Nephropathy |
Moderate |
Moribund Sacrifice |
Urinary System |
Kidney |
|
1000 mg/kg |
50 |
199 |
199 |
522 |
1 |
Nephropathy |
Moderate |
Moribund Sacrifice |
Urinary System |
Kidney |
|
1000 mg/kg |
50 |
154 |
154 |
686 |
1 |
Nephropathy |
Moderate |
Natural Death |
Urinary System |
Kidney |
|
1000 mg/kg |
50 |
155 |
155 |
609 |
1 |
Nephropathy |
Mild |
Natural Death |
Urinary System |
Kidney |
|
1000 mg/kg |
50 |
158 |
158 |
686 |
1 |
Nephropathy |
Mild |
Natural Death |
Urinary System |
Kidney |
|
1000 mg/kg |
50 |
160 |
160 |
421 |
1 |
Nephropathy |
Moderate |
Natural Death |
Urinary System |
Kidney |
|
1000 mg/kg |
50 |
163 |
163 |
718 |
1 |
Nephropathy |
Mild |
Natural Death |
Urinary System |
Kidney |
|
1000 mg/kg |
50 |
164 |
164 |
653 |
1 |
Nephropathy |
Mild |
Natural Death |
Urinary System |
Kidney |
|
1000 mg/kg |
50 |
169 |
169 |
537 |
1 |
Nephropathy |
Mild |
Natural Death |
Urinary System |
Kidney |
|
1000 mg/kg |
50 |
171 |
171 |
385 |
1 |
Nephropathy |
Mild |
Natural Death |
Urinary System |
Kidney |
|
1000 mg/kg |
50 |
173 |
173 |
411 |
1 |
Nephropathy |
Moderate |
Natural Death |
Urinary System |
Kidney |
|
1000 mg/kg |
50 |
174 |
174 |
543 |
1 |
Nephropathy |
Mild |
Natural Death |
Urinary System |
Kidney |
|
1000 mg/kg |
50 |
175 |
175 |
465 |
1 |
Nephropathy |
Minimal |
Natural Death |
Urinary System |
Kidney |
|
1000 mg/kg |
50 |
179 |
179 |
233 |
1 |
Nephropathy |
Minimal |
Natural Death |
Urinary System |
Kidney |
|
1000 mg/kg |
50 |
182 |
182 |
548 |
1 |
Nephropathy |
Moderate |
Natural Death |
Urinary System |
Kidney |
|
1000 mg/kg |
50 |
187 |
187 |
704 |
1 |
Nephropathy |
Minimal |
Natural Death |
Urinary System |
Kidney |
|
1000 mg/kg |
50 |
189 |
189 |
661 |
1 |
Nephropathy |
Mild |
Natural Death |
Urinary System |
Kidney |
|
1000 mg/kg |
50 |
192 |
192 |
130 |
1 |
Nephropathy |
Minimal |
Natural Death |
Urinary System |
Kidney |
|
1000 mg/kg |
50 |
193 |
193 |
484 |
1 |
Nephropathy |
Minimal |
Natural Death |
Urinary System |
Kidney |
|
1000 mg/kg |
50 |
194 |
194 |
424 |
1 |
Nephropathy |
Mild |
Natural Death |
Urinary System |
Kidney |
|
1000 mg/kg |
50 |
195 |
195 |
408 |
1 |
Nephropathy |
Mild |
Natural Death |
Urinary System |
Kidney |
|
1000 mg/kg |
50 |
196 |
196 |
459 |
1 |
Nephropathy |
Minimal |
Natural Death |
Urinary System |
Kidney |
|
1000 mg/kg |
50 |
200 |
200 |
704 |
1 |
Nephropathy |
Mild |
Natural Death |
Urinary System |
Kidney |
|
1000 mg/kg |
50 |
153 |
153 |
732 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
1000 mg/kg |
50 |
159 |
159 |
731 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
1000 mg/kg |
50 |
161 |
161 |
731 |
1 |
Nephropathy |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
|
1000 mg/kg |
50 |
162 |
162 |
730 |
1 |
Nephropathy |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
|
1000 mg/kg |
50 |
166 |
166 |
730 |
1 |
Nephropathy |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
|
1000 mg/kg |
50 |
172 |
172 |
730 |
1 |
Nephropathy |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
|
1000 mg/kg |
50 |
176 |
176 |
730 |
1 |
Nephropathy |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
|
1000 mg/kg |
50 |
181 |
181 |
731 |
1 |
Nephropathy |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
|
1000 mg/kg |
50 |
184 |
184 |
732 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Urinary Bladder |
Transit Epithe |
Vehicle Control |
50 |
32 |
32 |
731 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Urinary System |
Urinary Bladder |
Transit Epithe |
250 mg/kg |
50 |
75 |
75 |
708 |
1 |
Hyperplasia |
Moderate |
Moribund Sacrifice |
Urinary System |
Urinary Bladder |
Transit Epithe |
1000 mg/kg |
50 |
199 |
199 |
522 |
1 |
Hyperplasia |
Marked |
Moribund Sacrifice |
Urinary System |
Urinary Bladder |
|
1000 mg/kg |
50 |
199 |
199 |
522 |
1 |
Inflammation |
Mild |
Moribund Sacrifice |