If this is the first time you are viewing this file, please choose 'Save As' from the 'File' menu
and resave this file as an Excel file type. This will greatly speed up future viewings of this file.
Current Search Critera
Short-Term Study
Individual Animal Clinical Observations
Study Information:
Chemical Name: | Tetrahydrofuran |
CASRN: | ="109-99-9" |
Study Number: | C60560B |
Exposure Route: | RESPIRATORY EXPOSURE WHOLE BODY |
TDMS Number: | 0518102 |
Sex: | Male |
Strain and Species: | B6C3F1 Mice |
Animal Number |
Dose Group |
Clinical Observation |
Qualifier |
Incident Number |
Observation Date |
First Dose Date |
Days On Study |
Removal Observation |
8 |
Vehicle Control |
Ruffled Fur |
|
|
02/23/1987 |
02/12/87 |
12.00 |
No |
10 |
Vehicle Control |
Alopecia |
Body Ventral, 3- 5 Mm |
|
03/16/1987 |
02/12/87 |
33.00 |
No |
10 |
Vehicle Control |
Alopecia |
Body Ventral, 16-20 Mm |
|
03/23/1987 |
02/12/87 |
40.00 |
No |
10 |
Vehicle Control |
Alopecia |
Body Ventral, 26 Or Gr |
|
03/30/1987 |
02/12/87 |
47.00 |
No |
10 |
Vehicle Control |
Alopecia |
Body Ventral, 26 Or Gr |
|
04/06/1987 |
02/12/87 |
54.00 |
No |
10 |
Vehicle Control |
Alopecia |
Body Ventral, 21-25 Mm |
|
04/13/1987 |
02/12/87 |
61.00 |
No |
10 |
Vehicle Control |
Alopecia |
Body Ventral, 26 Or Gr |
|
04/20/1987 |
02/12/87 |
68.00 |
No |
10 |
Vehicle Control |
Alopecia |
Body Ventral, 26 Or Gr |
|
04/27/1987 |
02/12/87 |
75.00 |
No |
10 |
Vehicle Control |
Alopecia |
Body Ventral, 26 Or Gr |
|
05/04/1987 |
02/12/87 |
82.00 |
No |
10 |
Vehicle Control |
Alopecia |
Body Ventral, 26 Or Gr |
|
05/11/1987 |
02/12/87 |
89.00 |
No |
201 |
66 PPM |
Alopecia |
Body Ventral, 16-20 Mm |
|
03/16/1987 |
02/12/87 |
33.00 |
No |
201 |
66 PPM |
Alopecia |
Body Ventral, 21-25 Mm |
|
03/23/1987 |
02/12/87 |
40.00 |
No |
201 |
66 PPM |
Alopecia |
Body Ventral, 16-20 Mm |
|
03/30/1987 |
02/12/87 |
47.00 |
No |
201 |
66 PPM |
Alopecia |
Body Ventral, 3- 5 Mm |
|
04/06/1987 |
02/12/87 |
54.00 |
No |
201 |
66 PPM |
Alopecia |
Body Ventral, 3- 5 Mm |
|
04/27/1987 |
02/12/87 |
75.00 |
No |
201 |
66 PPM |
Alopecia |
Body Ventral, 3- 5 Mm |
|
05/11/1987 |
02/12/87 |
89.00 |
No |
201 |
66 PPM |
Alopecia |
Body Ventral, 3- 5 Mm |
|
05/15/1987 |
02/12/87 |
93.00 |
Yes |
202 |
66 PPM |
Alopecia |
Body Ventral, 3- 5 Mm |
|
03/30/1987 |
02/12/87 |
47.00 |
No |
202 |
66 PPM |
Alopecia |
Body Ventral, 6-10 Mm |
|
04/13/1987 |
02/12/87 |
61.00 |
No |
202 |
66 PPM |
Alopecia |
Body Ventral, 3- 5 Mm |
|
04/20/1987 |
02/12/87 |
68.00 |
No |
202 |
66 PPM |
Alopecia |
Body Ventral, 6-10 Mm |
|
05/04/1987 |
02/12/87 |
82.00 |
No |
202 |
66 PPM |
Alopecia |
Body Ventral, 3- 5 Mm |
|
05/11/1987 |
02/12/87 |
89.00 |
No |
204 |
66 PPM |
Ruffled Fur |
|
|
03/02/1987 |
02/12/87 |
19.00 |
No |
204 |
66 PPM |
Ruffled Fur |
|
|
03/09/1987 |
02/12/87 |
26.00 |
No |
204 |
66 PPM |
Ruffled Fur |
|
|
03/30/1987 |
02/12/87 |
47.00 |
No |
208 |
66 PPM |
Alopecia |
Body Ventral, 3- 5 Mm |
|
03/30/1987 |
02/12/87 |
47.00 |
No |
208 |
66 PPM |
Ruffled Fur |
|
|
04/06/1987 |
02/12/87 |
54.00 |
No |
208 |
66 PPM |
Alopecia |
Body Ventral, 3- 5 Mm |
|
04/06/1987 |
02/12/87 |
54.00 |
No |
208 |
66 PPM |
Ruffled Fur |
|
|
04/20/1987 |
02/12/87 |
68.00 |
No |
208 |
66 PPM |
Alopecia |
Body Ventral, 11-15 Mm |
|
04/20/1987 |
02/12/87 |
68.00 |
No |
208 |
66 PPM |
Alopecia |
Body Ventral, 6-10 Mm |
|
04/27/1987 |
02/12/87 |
75.00 |
No |
208 |
66 PPM |
Alopecia |
Body Ventral, 11-15 Mm |
|
05/04/1987 |
02/12/87 |
82.00 |
No |
208 |
66 PPM |
Alopecia |
Body Ventral, 11-15 Mm |
|
05/11/1987 |
02/12/87 |
89.00 |
No |
209 |
66 PPM |
Ruffled Fur |
|
|
03/30/1987 |
02/12/87 |
47.00 |
No |
209 |
66 PPM |
Ruffled Fur |
|
|
04/06/1987 |
02/12/87 |
54.00 |
No |
210 |
66 PPM |
Ruffled Fur |
|
|
02/23/1987 |
02/12/87 |
12.00 |
No |
210 |
66 PPM |
Ruffled Fur |
|
|
03/02/1987 |
02/12/87 |
19.00 |
No |
210 |
66 PPM |
Ruffled Fur |
|
|
03/09/1987 |
02/12/87 |
26.00 |
No |
210 |
66 PPM |
Ruffled Fur |
|
|
03/30/1987 |
02/12/87 |
47.00 |
No |
210 |
66 PPM |
Ruffled Fur |
|
|
04/06/1987 |
02/12/87 |
54.00 |
No |
210 |
66 PPM |
Ruffled Fur |
|
|
04/13/1987 |
02/12/87 |
61.00 |
No |
403 |
200 PPM |
Ruffled Fur |
|
|
03/02/1987 |
02/12/87 |
19.00 |
No |
406 |
200 PPM |
Alopecia |
Body Ventral, 3- 5 Mm |
|
03/30/1987 |
02/12/87 |
47.00 |
No |
406 |
200 PPM |
Alopecia |
Body Ventral, 3- 5 Mm |
|
04/13/1987 |
02/12/87 |
61.00 |
No |
406 |
200 PPM |
Alopecia |
Body Ventral, 16-20 Mm |
|
04/20/1987 |
02/12/87 |
68.00 |
No |
406 |
200 PPM |
Alopecia |
Body Ventral, 16-20 Mm |
|
04/27/1987 |
02/12/87 |
75.00 |
No |
406 |
200 PPM |
Alopecia |
Body Ventral, 16-20 Mm |
|
05/04/1987 |
02/12/87 |
82.00 |
No |
406 |
200 PPM |
Alopecia |
Body Ventral, 21-25 Mm |
|
05/11/1987 |
02/12/87 |
89.00 |
No |
406 |
200 PPM |
Alopecia |
Body Ventral, 21-25 Mm |
|
05/15/1987 |
02/12/87 |
93.00 |
Yes |
407 |
200 PPM |
Alopecia |
Body Ventral, 3- 5 Mm |
|
04/06/1987 |
02/12/87 |
54.00 |
No |
407 |
200 PPM |
Ruffled Fur |
|
|
04/13/1987 |
02/12/87 |
61.00 |
No |
407 |
200 PPM |
Alopecia |
Body Ventral, 11-15 Mm |
|
04/13/1987 |
02/12/87 |
61.00 |
No |
407 |
200 PPM |
Ruffled Fur |
|
|
04/20/1987 |
02/12/87 |
68.00 |
No |
407 |
200 PPM |
Alopecia |
Body Ventral, 6-10 Mm |
|
04/20/1987 |
02/12/87 |
68.00 |
No |
407 |
200 PPM |
Alopecia |
Body Ventral, 11-15 Mm |
|
05/04/1987 |
02/12/87 |
82.00 |
No |
407 |
200 PPM |
Alopecia |
Body Ventral, 16-20 Mm |
|
05/11/1987 |
02/12/87 |
89.00 |
No |
410 |
200 PPM |
Ruffled Fur |
|
|
02/23/1987 |
02/12/87 |
12.00 |
No |
410 |
200 PPM |
Ruffled Fur |
|
|
03/02/1987 |
02/12/87 |
19.00 |
No |
410 |
200 PPM |
Ruffled Fur |
|
|
03/09/1987 |
02/12/87 |
26.00 |
No |
410 |
200 PPM |
Ruffled Fur |
|
|
03/30/1987 |
02/12/87 |
47.00 |
No |
410 |
200 PPM |
Ruffled Fur |
|
|
04/06/1987 |
02/12/87 |
54.00 |
No |
602 |
600 PPM |
Ruffled Fur |
|
|
03/02/1987 |
02/12/87 |
19.00 |
No |
602 |
600 PPM |
Ruffled Fur |
|
|
04/06/1987 |
02/12/87 |
54.00 |
No |
605 |
600 PPM |
Alopecia |
Body Ventral, 3- 5 Mm |
|
05/04/1987 |
02/12/87 |
82.00 |
No |
605 |
600 PPM |
Alopecia |
Body Ventral, 21-25 Mm |
|
05/15/1987 |
02/12/87 |
93.00 |
Yes |
606 |
600 PPM |
Alopecia |
Groin, 11-15 Mm |
|
05/11/1987 |
02/12/87 |
89.00 |
No |
606 |
600 PPM |
Alopecia |
Groin, 6-10 Mm |
|
05/15/1987 |
02/12/87 |
93.00 |
Yes |
608 |
600 PPM |
Alopecia |
Body Ventral, 3- 5 Mm |
|
05/04/1987 |
02/12/87 |
82.00 |
No |
608 |
600 PPM |
Alopecia |
Body Ventral, 6-10 Mm |
|
05/15/1987 |
02/12/87 |
93.00 |
Yes |
609 |
600 PPM |
Swelling |
Left Rear Leg |
|
05/04/1987 |
02/12/87 |
82.00 |
No |
610 |
600 PPM |
Alopecia |
Body Ventral, 16-20 Mm |
|
03/09/1987 |
02/12/87 |
26.00 |
No |
610 |
600 PPM |
Alopecia |
Body Ventral, 6-10 Mm |
|
03/16/1987 |
02/12/87 |
33.00 |
No |
610 |
600 PPM |
Alopecia |
Body Ventral, 16-20 Mm |
|
03/23/1987 |
02/12/87 |
40.00 |
No |
610 |
600 PPM |
Alopecia |
Body Ventral, 26 Or Gr |
|
03/30/1987 |
02/12/87 |
47.00 |
No |
610 |
600 PPM |
Alopecia |
Body Ventral, 26 Or Gr |
|
04/06/1987 |
02/12/87 |
54.00 |
No |
610 |
600 PPM |
Alopecia |
Right Front Leg, 6-10 Mm |
|
04/06/1987 |
02/12/87 |
54.00 |
No |
610 |
600 PPM |
Alopecia |
Body Ventral, 16-20 Mm |
|
04/13/1987 |
02/12/87 |
61.00 |
No |
610 |
600 PPM |
Alopecia |
Body Ventral, 26 Or Gr |
|
04/20/1987 |
02/12/87 |
68.00 |
No |
610 |
600 PPM |
Alopecia |
Body Ventral, 16-20 Mm |
|
04/27/1987 |
02/12/87 |
75.00 |
No |
610 |
600 PPM |
Alopecia |
Body Ventral, 3- 5 Mm |
|
05/04/1987 |
02/12/87 |
82.00 |
No |
610 |
600 PPM |
Alopecia |
Body Ventral, 26 Or Gr |
|
05/11/1987 |
02/12/87 |
89.00 |
No |
610 |
600 PPM |
Alopecia |
Body Ventral, 6-10 Mm |
|
05/15/1987 |
02/12/87 |
93.00 |
Yes |
801 |
1800 PPM |
Alopecia |
Body Ventral, 6-10 Mm |
|
05/15/1987 |
02/12/87 |
93.00 |
Yes |
803 |
1800 PPM |
Ruffled Fur |
|
|
03/16/1987 |
02/12/87 |
33.00 |
No |
803 |
1800 PPM |
Ruffled Fur |
|
|
03/30/1987 |
02/12/87 |
47.00 |
No |
803 |
1800 PPM |
Alopecia |
Head, 6-10 Mm |
|
04/06/1987 |
02/12/87 |
54.00 |
No |
803 |
1800 PPM |
Ruffled Fur |
|
|
04/06/1987 |
02/12/87 |
54.00 |
No |
803 |
1800 PPM |
Ruffled Fur |
|
|
04/13/1987 |
02/12/87 |
61.00 |
No |
803 |
1800 PPM |
Ruffled Fur |
|
|
04/20/1987 |
02/12/87 |
68.00 |
No |
803 |
1800 PPM |
Ruffled Fur |
|
|
05/04/1987 |
02/12/87 |
82.00 |
No |
808 |
1800 PPM |
Alopecia |
Body Dorsal, 6-10 Mm |
|
05/15/1987 |
02/12/87 |
93.00 |
Yes |
1001 |
5000 PPM |
Hypoactivity |
|
|
02/12/1987 |
02/12/87 |
1.00 |
No |
1002 |
5000 PPM |
Hypoactivity |
|
|
02/12/1987 |
02/12/87 |
1.00 |
No |
1003 |
5000 PPM |
Hypoactivity |
|
|
02/12/1987 |
02/12/87 |
1.00 |
No |
1004 |
5000 PPM |
Hypoactivity |
|
|
02/12/1987 |
02/12/87 |
1.00 |
No |
1004 |
5000 PPM |
Emaciated |
|
|
02/16/1987 |
02/12/87 |
5.00 |
No |
1005 |
5000 PPM |
Hypoactivity |
|
|
02/12/1987 |
02/12/87 |
1.00 |
No |
1008 |
5000 PPM |
Emaciated |
|
|
02/16/1987 |
02/12/87 |
5.00 |
No |
1010 |
5000 PPM |
Emaciated |
|
|
03/05/1987 |
02/12/87 |
22.00 |
Yes |
1010 |
5000 PPM |
Abnormal Posture |
|
|
03/05/1987 |
02/12/87 |
22.00 |
Yes |
1010 |
5000 PPM |
Dyspnea |
|
|
03/05/1987 |
02/12/87 |
22.00 |
Yes |
1010 |
5000 PPM |
Hypoactivity |
|
|
03/05/1987 |
02/12/87 |
22.00 |
Yes |