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Chemical Name: | alpha/beta Thujone Mixture |
---|---|
CASRN: | ="76231-76-0" |
Study Number: | C99037B |
Study Length (Year Completed): | 13 Weeks (N/A) |
Exposure Route: | GAV |
TDMS Number: | 9903798.ss |
Sex: | Male |
Strain and Species: | Fischer 344 Rats |
Clinical Chemistry Individual Animal Data | ||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Measurement Time | Animal Number | Dose Group (mg/kg) | Control Code | BUN (mg_dL) | Creat (U per L) | TP (g_dL) | ALB (g_dL) | Creat Kinase (IU_L) | ALT (IU_L) | SDH (IU_L) | ALP (IU_L) | TBA (umol per g) |
Day 4 | 0121 | 0 | 18.0 | 0.5 | 5.4 | 4.1 | 657 | 47 | 4.0 | 595 | 24.6 | |
Day 4 | 0122 | 0 | 17.4 | 0.5 | 5.6 | 4.0 | 629 | 50 | 10.0 | 694 | 30.0 | |
Day 4 | 0123 | 0 | 16.5 | 0.5 | 5.9 | 4.2 | 535 | 52 | 11.4 | 660 | 20.0 | |
Day 4 | 0124 | 0 | 16.1 | 0.5 | 5.8 | 4.1 | 603 | 54 | 4.6 | 657 | 19.1 | |
Day 4 | 0125 | 0 | 14.4 | 0.5 | 5.6 | 4.0 | 426 | 48 | 8.0 | 602 | 26.6 | |
Day 4 | 0126 | 0 | 17.0 | 0.5 | 5.8 | 4.2 | 413 | 50 | 7.3 | 593 | 29.1 | |
Day 4 | 0127 | 0 | 15.7 | 0.5 | 5.8 | 4.2 | 702 | 62 | 2.0 | 722 | 26.5 | |
Day 4 | 0128 | 0 | 14.5 | 0.5 | 5.8 | 4.3 | 628 | 54 | 1.5 | 611 | 17.9 | |
Day 4 | 0129 | 0 | 15.7 | 0.5 | 5.6 | 4.1 | 694 | 52 | 3.7 | 611 | 34.1 | |
Day 4 | 0130 | 0 | 14.0 | 0.5 | 5.6 | 4.0 | 598 | 61 | 1.7 | 655 | 29.4 | |
Day 4 | 0131 | 12.5 | 16.1 | 0.5 | 5.4 | 4.0 | 628 | 48 | 4.0 | 620 | 24.3 | |
Day 4 | 0132 | 12.5 | 19.4 | 0.5 | 5.8 | 4.2 | 527 | 58 | 6.3 | 608 | 21.8 | |
Day 4 | 0133 | 12.5 | 16.7 | 0.5 | 5.6 | 4.0 | 652 | 54 | 5.3 | 620 | 17.6 | |
Day 4 | 0134 | 12.5 | 15.6 | 0.5 | 5.8 | 4.1 | 366 | 52 | 10.5 | 579 | 20.2 | |
Day 4 | 0135 | 12.5 | 15.5 | 0.5 | 5.5 | 4.0 | 435 | 60 | 8.5 | 633 | 25.2 | |
Day 4 | 0136 | 12.5 | 14.7 | 0.5 | 5.7 | 4.1 | 579 | 52 | 3.5 | 617 | 27.9 | |
Day 4 | 0137 | 12.5 | 14.1 | 0.5 | 5.7 | 4.2 | 574 | 63 | 4.2 | 629 | 19.1 | |
Day 4 | 0138 | 12.5 | 14.9 | 0.5 | 5.8 | 4.3 | 483 | 61 | 5.9 | 639 | 27.3 | |
Day 4 | 0139 | 12.5 | 14.5 | 0.5 | 5.7 | 4.2 | 471 | 53 | 7.0 | 641 | 24.8 | |
Day 4 | 0140 | 12.5 | 12.8 | 0.4 | 5.7 | 4.0 | 696 | 58 | 0.5 | 637 | 28.8 | |
Day 4 | 0141 | 25 | 17.1 | 0.5 | 5.4 | 4.0 | 616 | 46 | 6.3 | 656 | 19.1 | |
Day 4 | 0142 | 25 | 15.4 | 0.5 | 5.6 | 4.1 | 468 | 55 | 12.2 | 668 | 20.6 | |
Day 4 | 0143 | 25 | 16.0 | 0.5 | 5.8 | 4.1 | 472 | 59 | 9.6 | 659 | 20.1 | |
Day 4 | 0144 | 25 | 17.3 | 0.5 | 5.8 | 4.1 | 430 | 57 | 8.7 | 583 | 19.5 | |
Day 4 | 0145 | 25 | 14.3 | 0.5 | 5.8 | 4.2 | 530 | 61 | 5.4 | 623 | 20.1 | |
Day 4 | 0146 | 25 | 15.3 | 0.5 | 5.7 | 4.1 | 808 | 53 | 0.0 | 608 | 23.8 | |
Day 4 | 0147 | 25 | 15.1 | 0.5 | 5.7 | 4.2 | 601 | 54 | 4.7 | 581 | 19.9 | |
Day 4 | 0148 | 25 | 16.1 | 0.5 | 5.8 | 4.2 | 398 | 54 | 11.5 | 630 | 19.2 | |
Day 4 | 0149 | 25 | 16.0 | 0.6 | 6.1 | 4.4 | 452 | 68 | 10.4 | 607 | 25.1 | |
Day 4 | 0150 | 25 | 15.2 | 0.5 | 6.0 | 4.2 | 470 | 58 | 4.9 | 605 | 22.0 | |
Day 4 | 0151 | 50 | 17.0 | 0.5 | 5.5 | 4.0 | 614 | 49 | 9.3 | 591 | 20.9 | |
Day 4 | 0152 | 50 | 17.0 | 0.5 | 6.1 | 4.3 | 496 | 57 | 16.8 | 626 | 30.5 | |
Day 4 | 0153 | 50 | 17.6 | 0.5 | 5.9 | 4.3 | 420 | 54 | 8.0 | 611 | 30.7 | |
Day 4 | 0154 | 50 | 16.6 | 0.5 | 6.2 | 4.2 | 583 | 60 | 4.9 | 618 | 21.5 | |
Day 4 | 0155 | 50 | 16.4 | 0.5 | 5.5 | 4.1 | 464 | 53 | 9.2 | 631 | 26.5 | |
Day 4 | 0156 | 50 | 13.4 | 0.4 | 5.4 | 4.0 | 477 | 54 | 3.3 | 603 | 34.3 | |
Day 4 | 0157 | 50 | 14.6 | 0.5 | 5.9 | 4.3 | 658 | 53 | 0.4 | 662 | 27.2 | |
Day 4 | 0158 | 50 | 16.3 | 0.5 | 5.7 | 4.2 | 498 | 56 | 6.9 | 611 | 20.5 | |
Day 4 | 0159 | 50 | 17.4 | 0.5 | 6.3 | 4.3 | 473 | 52 | 9.3 | 626 | 26.4 | |
Day 4 | 0160 | 50 | 15.0 | 0.5 | 5.8 | 4.1 | 720 | 53 | 2.8 | 584 | 20.3 | |
Day 4 | 0161 | 75 | 16.1 | 0.4 | 5.4 | 3.9 | 724 | 54 | 5.7 | 599 | 22.4 | |
Day 4 | 0162 | 75 | 17.8 | 0.5 | 5.5 | 3.9 | 738 | 49 | 6.3 | 554 | 22.6 | |
Day 4 | 0163 | 75 | 16.4 | 0.5 | 5.9 | 4.1 | 591 | 63 | 4.2 | 579 | 18.6 | |
Day 4 | 0164 | 75 | 18.1 | 0.5 | 6.3 | 4.6 | 301 | 61 | 11.2 | 673 | 25.1 | |
Day 4 | 0165 | 75 | 15.4 | 0.5 | 5.6 | 4.1 | 518 | 59 | 3.0 | 595 | 21.6 | |
Day 4 | 0166 | 75 | 15.2 | 0.5 | 5.5 | 4.0 | 609 | 50 | 0.3 | 606 | 27.1 | |
Day 4 | 0167 | 75 | 15.9 | 0.5 | 6.0 | 4.4 | 517 | 56 | 7.9 | 593 | 21.0 | |
Day 4 | 0168 | 75 | 14.8 | 0.5 | 5.7 | 4.1 | 714 | 49 | 0.8 | 639 | 25.0 | |
Day 4 | 0169 | 75 | 16.4 | 0.5 | 5.8 | 4.2 | 630 | 61 | 4.8 | 610 | 21.2 | |
Day 4 | 0170 | 75 | 13.1 | 0.4 | 5.7 | 4.2 | 629 | 66 | 0.5 | 621 | 21.2 | |
Day 4 | 0171 | 100 | 16.1 | 0.5 | 5.4 | 4.0 | 537 | 53 | 6.6 | 589 | 20.6 | |
Day 4 | 0172 | 100 | 17.9 | 0.5 | 5.7 | 4.2 | 557 | 56 | 8.6 | 638 | 17.7 | |
Day 4 | 0173 | 100 | 18.3 | 0.5 | 6.3 | 4.4 | 596 | 49 | 8.1 | 603 | 23.7 | |
Day 4 | 0174 | 100 | 20.0 | 0.5 | 6.1 | 4.2 | 518 | 52 | 3.8 | 552 | 24.1 | |
Day 4 | 0175 | 100 | 14.5 | 0.5 | 6.0 | 4.2 | 437 | 61 | 9.5 | 613 | 30.8 | |
Day 4 | 0176 | 100 | 16.3 | 0.5 | 5.8 | 3.9 | 375 | 79 | 16.2 | 477 | 24.7 | |
Day 4 | 0177 | 100 | 16.6 | 0.5 | 6.0 | 4.3 | 493 | 53 | 5.1 | 582 | 19.8 | |
Day 4 | 0178 | 100 | 13.5 | 0.5 | 5.6 | 4.1 | 525 | 56 | 3.5 | 577 | 20.0 | |
Day 4 | 0179 | 100 | 14.4 | 0.5 | 5.6 | 4.1 | 592 | 62 | 2.2 | 640 | 19.0 | |
Day 4 | 0180 | 100 | 12.9 | 0.5 | 6.1 | 4.3 | 403 | 63 | 7.2 | 603 | 23.1 | |
Day 25 | 0121 | 0 | 21.5 | 0.6 | 5.9 | 4.1 | 208 | 55 | 12.4 | 375 | 26.3 | |
Day 25 | 0122 | 0 | 22.4 | 0.6 | 6.2 | 4.3 | 216 | 61 | 12.7 | 392 | 17.8 | |
Day 25 | 0123 | 0 | 20.5 | 0.5 | 6.2 | 4.3 | 266 | 67 | 6.8 | 417 | 15.9 | |
Day 25 | 0124 | 0 | 21.6 | 0.6 | 6.5 | 4.4 | 157 | 61 | 12.7 | 412 | 19.3 | |
Day 25 | 0125 | 0 | 23.7 | 0.6 | 6.4 | 4.3 | 337 | 63 | 12.5 | 409 | 23.6 | |
Day 25 | 0126 | 0 | 19.6 | 0.6 | 6.1 | 4.2 | 162 | 59 | 14.2 | 377 | 25.2 | |
Day 25 | 0127 | 0 | 22.0 | 0.6 | 6.4 | 4.3 | 363 | 61 | 11 | 378 | 35.1 | |
Day 25 | 0128 | 0 | 21.3 | 0.6 | 6.8 | 4.5 | 166 | 67 | 14.7 | 399 | 21.8 | |
Day 25 | 0129 | 0 | 22.6 | 0.6 | 6.1 | 4.3 | 334 | 69 | 9.7 | 419 | 28.8 | |
Day 25 | 0130 | 0 | 19.5 | 0.7 | 6.5 | 4.3 | 222 | 58 | 15.3 | 422 | 38.9 | |
Day 25 | 0131 | 12.5 | 18.4 | 0.6 | 6.2 | 4.3 | 211 | 49 | 13.4 | 388 | 30.8 | |
Day 25 | 0132 | 12.5 | 14.9 | 0.6 | 6.0 | 4.2 | 295 | 53 | 11.3 | 378 | 29.2 | |
Day 25 | 0133 | 12.5 | 18.7 | 0.6 | 6.4 | 4.3 | 231 | 61 | 9.0 | 421 | 18.8 | |
Day 25 | 0134 | 12.5 | 15.9 | 0.7 | 6.3 | 4.1 | 310 | 54 | 10.1 | 367 | 19.0 | |
Day 25 | 0135 | 12.5 | 17.7 | 0.6 | 6.1 | 4.3 | 181 | 56 | 14.2 | 384 | 19.4 | |
Day 25 | 0136 | 12.5 | 18.0 | 0.6 | 6.0 | 4.2 | 196 | 53 | 15.6 | 381 | 28.3 | |
Day 25 | 0137 | 12.5 | 16.6 | 0.6 | 5.9 | 4.1 | 334 | 60 | 7.9 | 377 | 16.6 | |
Day 25 | 0138 | 12.5 | 18.8 | 0.6 | 6.6 | 4.3 | 382 | 53 | 12.9 | 388 | 25.8 | |
Day 25 | 0139 | 12.5 | 18.3 | 0.6 | 6.4 | 4.2 | 270 | 57 | 14.4 | 409 | 24.3 | |
Day 25 | 0140 | 12.5 | 19.3 | 0.6 | 6.3 | 4.2 | 346 | 56 | 8.8 | 404 | 21.0 | |
Day 25 | 0141 | 25 | 21.8 | 0.6 | 6.4 | 4.3 | 161 | 56 | 13.8 | 389 | 30.7 | |
Day 25 | 0142 | 25 | 20.7 | 0.6 | 6.6 | 4.3 | 199 | 59 | 17.1 | 388 | 19.5 | |
Day 25 | 0143 | 25 | 20.6 | 0.6 | 6.4 | 4.4 | 232 | 61 | 12.1 | 411 | 18.7 | |
Day 25 | 0144 | 25 | 22.0 | 0.6 | 6.6 | 4.4 | 281 | 69 | 10.6 | 390 | 27.0 | |
Day 25 | 0145 | 25 | 22.3 | 0.6 | 6.6 | 4.4 | 297 | 70 | 14.6 | 418 | 21.8 | |
Day 25 | 0146 | 25 | 19.0 | 0.6 | 6.2 | 4.2 | 166 | 55 | 13.1 | 384 | 31.9 | |
Day 25 | 0147 | 25 | 17.3 | 0.6 | 6.3 | 4.3 | 209 | 52 | 16.1 | 372 | 20.9 | |
Day 25 | 0148 | 25 | 17.6 | 0.6 | 6.3 | 4.2 | 304 | 58 | 17.8 | 405 | 24.3 | |
Day 25 | 0149 | 25 | 17.8 | 0.6 | 6.4 | 4.3 | 361 | 57 | 7.6 | 406 | 25.3 | |
Day 25 | 0150 | 25 | 17.8 | 0.6 | 6.4 | 4.2 | 277 | 59 | 14.6 | 430 | 31.5 | |
Day 25 | 0151 | 50 | 18.9 | 0.6 | 6.2 | 4.3 | 176 | 59 | 15.9 | 415 | 16.6 | |
Day 25 | 0152 | 50 | 19.7 | 0.6 | 6.5 | 4.4 | 167 | 65 | 14.0 | 377 | 30.1 | |
Day 25 | 0153 | 50 | 20.3 | 0.6 | 6.4 | 4.3 | 208 | 57 | 13.8 | 411 | 26.3 | |
Day 25 | 0154 | 50 | 21.4 | 0.6 | 6.5 | 4.3 | 312 | 56 | 8.3 | 386 | 24.1 | |
Day 25 | 0155 | 50 | 20.5 | 0.6 | 6.2 | 4.3 | 212 | 54 | 11.5 | 398 | 29.5 | |
Day 25 | 0156 | 50 | 17.2 | 0.5 | 5.9 | 4.2 | 171 | 52 | 11.1 | 352 | 19.7 | |
Day 25 | 0157 | 50 | 17.6 | 0.6 | 6.3 | 4.2 | 298 | 56 | 18.3 | 379 | 25.5 | |
Day 25 | 0158 | 50 | 16.8 | 0.6 | 6.4 | 4.2 | 421 | 55 | 13.1 | 380 | 19.5 | |
Day 25 | 0159 | 50 | 17.3 | 0.6 | 6.3 | 4.3 | 206 | 54 | 15.4 | 401 | 23.5 | |
Day 25 | 0160 | 50 | 15.8 | 0.6 | 6.3 | 4.3 | 350 | 51 | 6.9 | 385 | 22.0 | |
Day 25 | 0161 | 75 | 21.2 | 0.6 | 6.0 | 4.1 | 266 | 67 | 15.9 | 368 | 26.9 | |
Day 25 | 0162 | 75 | 21.0 | 0.7 | 6.5 | 4.4 | 324 | 67 | 8.3 | 378 | 30.8 | |
Day 25 | 0163 | 75 | 21.3 | 0.6 | 6.1 | 4.3 | 250 | 62 | 11.1 | 384 | 30.9 | |
Day 25 | 0164 | 75 | 22.0 | 0.6 | 6.3 | 4.4 | 200 | 64 | 9.4 | 383 | 27.3 | |
Day 25 | 0165 | 75 | 23.3 | 0.6 | 6.1 | 4.2 | 299 | 65 | 7.6 | 398 | 20.0 | |
Day 25 | 0166 | 75 | 17.2 | 0.6 | 6.1 | 4.2 | 274 | 56 | 7.5 | 367 | 24.7 | |
Day 25 | 0167 | 75 | 17.3 | 0.6 | 6.3 | 4.2 | 259 | 59 | 16.3 | 356 | 23.4 | |
Day 25 | 0168 | 75 | 16.6 | 0.6 | 6.5 | 4.5 | 177 | 57 | 15.7 | 391 | 17.5 | |
Day 25 | 0169 | 75 | 17.8 | 0.6 | 6.0 | 4.2 | 400 | 52 | 8.5 | 353 | 33.2 | |
Day 25 | 0170 | 75 | 18.1 | 0.6 | 6.3 | 4.3 | 403 | 56 | 6.2 | 390 | 23.7 | |
Day 25 | 0171 | 100 | 16.8 | 0.6 | 6.0 | 4.2 | 210 | 54 | 12.8 | 411 | 30.6 | |
Day 25 | 0172 | 100 | 17.7 | 0.6 | 6.3 | 4.3 | 193 | 58 | 11.4 | 407 | 19.0 | |
Day 25 | 0173 | 100 | 17.9 | 0.7 | 6.7 | 4.4 | 250 | 55 | 8.1 | 347 | 18.4 | |
Day 25 | 0174 | 100 | 19.6 | 0.6 | 6.3 | 4.3 | 263 | 58 | 5.6 | 373 | 22.7 | |
Day 25 | 0175 | 100 | 18.5 | 0.6 | 6.0 | 4.3 | 246 | 57 | 8.8 | 375 | 29.5 | |
Day 25 | 0176 | 100 | 21.5 | 0.6 | 6.3 | 4.2 | 266 | 64 | 11.1 | 378 | 25.3 | |
Day 25 | 0177 | 100 | 19.8 | 0.6 | 6.6 | 4.4 | 215 | 61 | 16.2 | 388 | 19.4 | |
Day 25 | 0178 | 100 | 20.0 | 0.6 | 6.1 | 4.2 | 230 | 67 | 15.8 | 369 | 30.0 | |
Day 25 | 0179 | 100 | 21.1 | 0.7 | 6.3 | 4.2 | 272 | 59 | 11.6 | 382 | 20.1 | |
Day 25 | 0180 | 100 | 18.3 | 0.6 | 6.4 | 4.2 | 256 | 63 | 12.5 | 402 | 24.3 | |
Abbreviations: | ||||||||||||
NA: Not Available, BUN: Urea Nitrogen, Creat: Creatinine, TP: Protein Total, ALB: Albumin, Creat Kinase: Creatine Kinase, ALT: Alanine Aminotransferase, SDH: Sorbitol Dehydrogenase, ALP: Alkaline Phosphatase, TBA: Bile Acids Per G Tissue |