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Chemical Name: | Gum Guggul Extract |
---|---|
CASRN: | ="GUMGUGGULEXT" |
Study Number: | C20605 |
Exposure Route: | GAVAGE |
TDMS Number: | 2060502 |
Sex: | Male |
Strain and Species: | B6C3F1 Mice |
System | Organ | Site | Treatment Group | Number Examined | Cage Number | Animal Number | Days on Study | Lesion Found | Lesion Name | Lesion Qualifier | Removal Reason |
---|---|---|---|---|---|---|---|---|---|---|---|
Alimentary System | Liver | Centrilobular, Hepatocyte | 250 mg/kg | 10 | 89 | 89 | 92 | 1 | Vacuolization Cytoplasmic | Mild, Diffuse | Terminal Sacrifice |
Alimentary System | Liver | Vehicle Control | 10 | 10 | 10 | 92 | 1 | Infiltration Cellular | Minimal, Mixed Cell | Terminal Sacrifice | |
Alimentary System | Liver | Vehicle Control | 10 | 11 | 11 | 92 | 1 | Infiltration Cellular | Minimal, Mixed Cell | Terminal Sacrifice | |
Alimentary System | Liver | 250 mg/kg | 10 | 83 | 83 | 92 | 1 | Infiltration Cellular | Minimal, Mixed Cell | Terminal Sacrifice | |
Alimentary System | Liver | 250 mg/kg | 10 | 84 | 84 | 92 | 1 | Infiltration Cellular | Minimal, Mixed Cell | Terminal Sacrifice | |
Alimentary System | Liver | 250 mg/kg | 10 | 86 | 86 | 92 | 1 | Infiltration Cellular | Minimal, Mixed Cell | Terminal Sacrifice | |
Alimentary System | Liver | 250 mg/kg | 10 | 90 | 90 | 92 | 1 | Infiltration Cellular | Minimal, Mixed Cell | Terminal Sacrifice | |
Alimentary System | Stomach | Forestomach | 250 mg/kg | 10 | 88 | 88 | 92 | 1 | Hyperkeratosis | Minimal, Focal | Terminal Sacrifice |
Alimentary System | Stomach | Forestomach | 250 mg/kg | 10 | 88 | 88 | 92 | 1 | Hyperplasia | Minimal, Focal | Terminal Sacrifice |
Urinary System | Kidney | Vehicle Control | 10 | 9 | 9 | 92 | 1 | Nephropathy | Minimal | Terminal Sacrifice |