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Short-Term Individual Animal Non Neoplastic Diagnosis
Study Information:
Chemical Name: | Gum Guggul Extract |
CASRN: | ="GUMGUGGULEXT" |
Study Number: | C20605 |
Exposure Route: | GAVAGE |
TDMS Number: | 2060599 |
Sex: | FEMALE |
Strain and Species: | HSD Rats |
FEMALE Individual Animal Non Neoplastic Diagnoses
System |
Organ |
Site |
Treatment Group |
Number Examined |
Cage Number |
Animal Number |
Days on Study |
Lesion Found |
Lesion Name |
Lesion Qualifier |
Removal Reason |
Alimentary System |
Liver |
|
1000 mg/kg |
10 |
48 |
240 |
28 |
1 |
Fatty Change |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
62.5 mg/kg |
1 |
40 |
200 |
28 |
1 |
Fibrosis |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Blood Vessel |
|
Vehicle Control |
10 |
37 |
185 |
28 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
10 |
37 |
181 |
28 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
1000 mg/kg |
10 |
47 |
232 |
28 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
1000 mg/kg |
10 |
47 |
234 |
28 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
1000 mg/kg |
10 |
48 |
239 |
28 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
1000 mg/kg |
10 |
48 |
240 |
28 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
10 |
38 |
186 |
28 |
1 |
Vacuolization Cytoplasmic |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
10 |
38 |
189 |
28 |
1 |
Vacuolization Cytoplasmic |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
1000 mg/kg |
10 |
48 |
237 |
28 |
1 |
Vacuolization Cytoplasmic |
Minimal |
Terminal Sacrifice |
Genital System |
Uterus |
|
Vehicle Control |
10 |
37 |
183 |
28 |
1 |
Hyperplasia |
Minimal, Cystic |
Terminal Sacrifice |
Genital System |
Uterus |
|
1000 mg/kg |
10 |
47 |
232 |
28 |
1 |
Hyperplasia |
Mild, Cystic |
Terminal Sacrifice |
Genital System |
Uterus |
|
1000 mg/kg |
10 |
47 |
234 |
28 |
1 |
Hyperplasia |
Mild, Cystic |
Terminal Sacrifice |
Genital System |
Uterus |
|
1000 mg/kg |
10 |
48 |
239 |
28 |
1 |
Hyperplasia |
Mild, Cystic |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
62.5 mg/kg |
2 |
39 |
191 |
28 |
1 |
Hemorrhage |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
62.5 mg/kg |
2 |
39 |
192 |
28 |
1 |
Hemorrhage |
Marked |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
125 mg/kg |
1 |
41 |
203 |
28 |
1 |
Hemorrhage |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
250 mg/kg |
3 |
43 |
212 |
28 |
1 |
Hemorrhage |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
250 mg/kg |
3 |
43 |
213 |
28 |
1 |
Hemorrhage |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
250 mg/kg |
3 |
44 |
217 |
28 |
1 |
Hemorrhage |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
500 mg/kg |
2 |
45 |
224 |
28 |
1 |
Hemorrhage |
Marked |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
500 mg/kg |
2 |
46 |
227 |
28 |
1 |
Hemorrhage |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
1000 mg/kg |
1 |
47 |
234 |
28 |
1 |
Hemorrhage |
Marked |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
62.5 mg/kg |
2 |
39 |
192 |
28 |
1 |
Inflammation |
Marked, Chronic |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
500 mg/kg |
2 |
45 |
224 |
28 |
1 |
Inflammation |
Marked, Chronic |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
1000 mg/kg |
1 |
47 |
234 |
28 |
1 |
Inflammation |
Marked, Chronic |
Terminal Sacrifice |
Musculoskeletal System |
Skeletal Muscle |
|
62.5 mg/kg |
1 |
40 |
200 |
28 |
1 |
Degeneration |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
37 |
181 |
28 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
37 |
183 |
28 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
37 |
185 |
28 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
38 |
186 |
28 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
1000 mg/kg |
10 |
48 |
237 |
28 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |