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Short-Term Individual Animal Non Neoplastic Diagnosis
Study Information:
Chemical Name: | Gum Guggul Extract |
CASRN: | ="GUMGUGGULEXT" |
Study Number: | C20605 |
Exposure Route: | GAVAGE |
TDMS Number: | 2060599 |
Sex: | MALE |
Strain and Species: | HSD Rats |
MALE Individual Animal Non Neoplastic Diagnoses
System |
Organ |
Site |
Treatment Group |
Number Examined |
Cage Number |
Animal Number |
Days on Study |
Lesion Found |
Lesion Name |
Lesion Qualifier |
Removal Reason |
Alimentary System |
Stomach, Forestomach |
|
62.5 mg/kg |
2 |
27 |
133 |
28 |
1 |
Mineralization |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach, Forestomach |
|
62.5 mg/kg |
2 |
28 |
139 |
28 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
10 |
25 |
124 |
28 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
125 mg/kg |
1 |
29 |
145 |
28 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
10 |
26 |
127 |
28 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
1000 mg/kg |
10 |
35 |
172 |
28 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
1000 mg/kg |
10 |
35 |
174 |
28 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
1000 mg/kg |
10 |
36 |
178 |
28 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
1000 mg/kg |
10 |
36 |
180 |
28 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
1000 mg/kg |
10 |
35 |
171 |
28 |
1 |
Vacuolization Cytoplasmic |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
1000 mg/kg |
10 |
36 |
177 |
28 |
1 |
Vacuolization Cytoplasmic |
Minimal |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
|
Vehicle Control |
10 |
26 |
127 |
28 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Genital System |
Epididymis |
|
Vehicle Control |
10 |
25 |
125 |
28 |
1 |
Degeneration |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
250 mg/kg |
2 |
31 |
152 |
28 |
1 |
Hemorrhage |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
250 mg/kg |
2 |
32 |
160 |
28 |
1 |
Hemorrhage |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
250 mg/kg |
2 |
31 |
152 |
28 |
1 |
Inflammation |
Moderate, Chronic |
Terminal Sacrifice |
Urinary System |
Kidney |
|
1000 mg/kg |
10 |
35 |
172 |
28 |
1 |
Developmental Malformation |
Moderate |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
25 |
122 |
28 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
26 |
126 |
28 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
26 |
128 |
28 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
1000 mg/kg |
10 |
35 |
172 |
28 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
1000 mg/kg |
10 |
35 |
174 |
28 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
1000 mg/kg |
10 |
35 |
175 |
28 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
1000 mg/kg |
10 |
36 |
177 |
28 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
1000 mg/kg |
10 |
36 |
179 |
28 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
1000 mg/kg |
10 |
36 |
180 |
28 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |