Alimentary System |
Liver |
Bile Duct |
62.5 mg/kg |
10 |
4 |
17 |
93 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
62.5 mg/kg |
10 |
3 |
11 |
93 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
1 |
1 |
93 |
1 |
Hepatodiaphragmatic Nodule |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
62.5 mg/kg |
10 |
3 |
11 |
93 |
1 |
Hepatodiaphragmatic Nodule |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
10 |
10 |
47 |
93 |
1 |
Hepatodiaphragmatic Nodule |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
10 |
11 |
52 |
93 |
1 |
Hepatodiaphragmatic Nodule |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
10 |
12 |
59 |
93 |
1 |
Hepatodiaphragmatic Nodule |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
1 |
1 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
1 |
2 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
1 |
3 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
1 |
5 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
2 |
6 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
2 |
7 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
2 |
9 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
62.5 mg/kg |
10 |
3 |
11 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
62.5 mg/kg |
10 |
3 |
12 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
62.5 mg/kg |
10 |
3 |
13 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
62.5 mg/kg |
10 |
3 |
14 |
93 |
1 |
Infiltration Cellular |
Mild, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
62.5 mg/kg |
10 |
3 |
15 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
62.5 mg/kg |
10 |
4 |
16 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
62.5 mg/kg |
10 |
4 |
17 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
62.5 mg/kg |
10 |
4 |
19 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
62.5 mg/kg |
10 |
4 |
20 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
125 mg/kg |
10 |
5 |
21 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
125 mg/kg |
10 |
5 |
23 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
125 mg/kg |
10 |
5 |
24 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
125 mg/kg |
10 |
6 |
26 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
125 mg/kg |
10 |
6 |
27 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
125 mg/kg |
10 |
6 |
28 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
125 mg/kg |
10 |
6 |
29 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
250 mg/kg |
10 |
7 |
34 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
250 mg/kg |
10 |
8 |
37 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
250 mg/kg |
10 |
8 |
38 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
250 mg/kg |
10 |
8 |
39 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
250 mg/kg |
10 |
8 |
40 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
10 |
10 |
46 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
10 |
10 |
47 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
10 |
10 |
48 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
10 |
10 |
49 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
10 |
10 |
50 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
10 |
9 |
42 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
10 |
9 |
43 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
10 |
9 |
45 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
10 |
11 |
51 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
10 |
11 |
52 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
10 |
11 |
53 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
10 |
11 |
55 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Alimentary System |
Stomach |
Glandular |
1000 mg/kg |
10 |
12 |
59 |
93 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
10 |
1 |
1 |
93 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
10 |
1 |
2 |
93 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
10 |
1 |
3 |
93 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
10 |
1 |
5 |
93 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
10 |
2 |
10 |
93 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
10 |
2 |
6 |
93 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
10 |
2 |
7 |
93 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
10 |
2 |
8 |
93 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
10 |
2 |
9 |
93 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
1000 mg/kg |
10 |
11 |
51 |
93 |
1 |
Cardiomyopathy |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
1000 mg/kg |
10 |
11 |
52 |
93 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
1000 mg/kg |
10 |
11 |
53 |
93 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
1000 mg/kg |
10 |
11 |
54 |
93 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
1000 mg/kg |
10 |
11 |
55 |
93 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
1000 mg/kg |
10 |
12 |
57 |
93 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
1000 mg/kg |
10 |
12 |
58 |
93 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
1000 mg/kg |
10 |
12 |
60 |
93 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
10 |
1 |
2 |
93 |
1 |
Vacuolization Cytoplasmic |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
10 |
2 |
10 |
93 |
1 |
Vacuolization Cytoplasmic |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
10 |
2 |
7 |
93 |
1 |
Vacuolization Cytoplasmic |
Minimal |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
|
Vehicle Control |
10 |
2 |
6 |
93 |
1 |
Ultimobranchial Cyst |
|
Terminal Sacrifice |
Genital System |
Epididymis |
|
Vehicle Control |
10 |
1 |
4 |
93 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Genital System |
Preputial Gland |
|
Vehicle Control |
10 |
1 |
1 |
93 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Genital System |
Preputial Gland |
|
Vehicle Control |
10 |
1 |
2 |
93 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Genital System |
Preputial Gland |
|
Vehicle Control |
10 |
1 |
3 |
93 |
1 |
Inflammation |
Mild |
Terminal Sacrifice |
Genital System |
Preputial Gland |
|
Vehicle Control |
10 |
1 |
4 |
93 |
1 |
Inflammation |
Mild |
Terminal Sacrifice |
Genital System |
Preputial Gland |
|
Vehicle Control |
10 |
1 |
5 |
93 |
1 |
Inflammation |
Mild |
Terminal Sacrifice |
Genital System |
Preputial Gland |
|
Vehicle Control |
10 |
2 |
10 |
93 |
1 |
Inflammation |
Mild |
Terminal Sacrifice |
Genital System |
Preputial Gland |
|
Vehicle Control |
10 |
2 |
6 |
93 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Genital System |
Preputial Gland |
|
Vehicle Control |
10 |
2 |
7 |
93 |
1 |
Inflammation |
Mild |
Terminal Sacrifice |
Genital System |
Preputial Gland |
|
Vehicle Control |
10 |
2 |
8 |
93 |
1 |
Inflammation |
Mild |
Terminal Sacrifice |
Genital System |
Preputial Gland |
|
1000 mg/kg |
10 |
11 |
51 |
93 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Genital System |
Preputial Gland |
|
1000 mg/kg |
10 |
11 |
52 |
93 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Genital System |
Preputial Gland |
|
1000 mg/kg |
10 |
11 |
53 |
93 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Genital System |
Preputial Gland |
|
1000 mg/kg |
10 |
11 |
54 |
93 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Genital System |
Preputial Gland |
|
1000 mg/kg |
10 |
11 |
55 |
93 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Genital System |
Preputial Gland |
|
1000 mg/kg |
10 |
12 |
56 |
93 |
1 |
Inflammation |
Mild |
Terminal Sacrifice |
Genital System |
Preputial Gland |
|
1000 mg/kg |
10 |
12 |
57 |
93 |
1 |
Inflammation |
Moderate |
Terminal Sacrifice |
Genital System |
Preputial Gland |
|
1000 mg/kg |
10 |
12 |
59 |
93 |
1 |
Inflammation |
Moderate |
Terminal Sacrifice |
Genital System |
Preputial Gland |
|
1000 mg/kg |
10 |
12 |
60 |
93 |
1 |
Inflammation |
Mild |
Terminal Sacrifice |
Genital System |
Testes |
Seminif Tub |
Vehicle Control |
10 |
1 |
2 |
93 |
1 |
Degeneration |
Minimal |
Terminal Sacrifice |
Genital System |
Testes |
Seminif Tub |
Vehicle Control |
10 |
2 |
6 |
93 |
1 |
Degeneration |
Minimal |
Terminal Sacrifice |
Genital System |
Testes |
Seminif Tub |
Vehicle Control |
10 |
2 |
8 |
93 |
1 |
Degeneration |
Minimal |
Terminal Sacrifice |
Genital System |
Testes |
Seminif Tub |
62.5 mg/kg |
10 |
3 |
13 |
93 |
1 |
Degeneration |
Minimal |
Terminal Sacrifice |
Genital System |
Testes |
Seminif Tub |
125 mg/kg |
10 |
5 |
23 |
93 |
1 |
Degeneration |
Minimal |
Terminal Sacrifice |
Genital System |
Testes |
Seminif Tub |
125 mg/kg |
10 |
5 |
24 |
93 |
1 |
Degeneration |
Minimal |
Terminal Sacrifice |
Genital System |
Testes |
Seminif Tub |
250 mg/kg |
10 |
7 |
31 |
93 |
1 |
Degeneration |
Minimal |
Terminal Sacrifice |
Genital System |
Testes |
Seminif Tub |
250 mg/kg |
10 |
7 |
35 |
93 |
1 |
Degeneration |
Minimal |
Terminal Sacrifice |
Genital System |
Testes |
Seminif Tub |
250 mg/kg |
10 |
8 |
38 |
93 |
1 |
Degeneration |
Minimal |
Terminal Sacrifice |
Genital System |
Testes |
Seminif Tub |
500 mg/kg |
10 |
10 |
47 |
93 |
1 |
Degeneration |
Minimal |
Terminal Sacrifice |
Genital System |
Testes |
Seminif Tub |
500 mg/kg |
10 |
9 |
41 |
93 |
1 |
Degeneration |
Minimal |
Terminal Sacrifice |
Genital System |
Testes |
Seminif Tub |
500 mg/kg |
10 |
9 |
43 |
93 |
1 |
Degeneration |
Minimal |
Terminal Sacrifice |
Genital System |
Testes |
Seminif Tub |
1000 mg/kg |
10 |
11 |
52 |
93 |
1 |
Degeneration |
Minimal |
Terminal Sacrifice |
Genital System |
Testes |
Seminif Tub |
1000 mg/kg |
10 |
11 |
54 |
93 |
1 |
Degeneration |
Minimal |
Terminal Sacrifice |
Genital System |
Testes |
Seminif Tub |
1000 mg/kg |
10 |
11 |
55 |
93 |
1 |
Degeneration |
Minimal |
Terminal Sacrifice |
Genital System |
Testes |
Seminif Tub |
1000 mg/kg |
10 |
12 |
57 |
93 |
1 |
Degeneration |
Minimal |
Terminal Sacrifice |
Genital System |
Testes |
Seminif Tub |
1000 mg/kg |
10 |
12 |
58 |
93 |
1 |
Degeneration |
Minimal |
Terminal Sacrifice |
Genital System |
Testes |
Seminif Tub |
1000 mg/kg |
10 |
12 |
59 |
93 |
1 |
Degeneration |
Minimal |
Terminal Sacrifice |
Genital System |
Testes |
Seminif Tub |
1000 mg/kg |
10 |
12 |
60 |
93 |
1 |
Degeneration |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
125 mg/kg |
10 |
6 |
26 |
93 |
1 |
Ectasia |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
Vehicle Control |
10 |
1 |
1 |
93 |
1 |
Hyperplasia |
Mild, Lymphoid |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
Vehicle Control |
10 |
1 |
1 |
93 |
1 |
Hyperplasia |
Mild, Plasma Cell |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
Vehicle Control |
10 |
1 |
2 |
93 |
1 |
Hyperplasia |
Minimal, Plasma Cell |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
Vehicle Control |
10 |
1 |
5 |
93 |
1 |
Hyperplasia |
Minimal, Plasma Cell |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
Vehicle Control |
10 |
2 |
10 |
93 |
1 |
Hyperplasia |
Mild, Lymphoid |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
Vehicle Control |
10 |
2 |
10 |
93 |
1 |
Hyperplasia |
Minimal, Plasma Cell |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
Vehicle Control |
10 |
2 |
6 |
93 |
1 |
Hyperplasia |
Moderate, Lymphoid |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
Vehicle Control |
10 |
2 |
9 |
93 |
1 |
Hyperplasia |
Mild, Plasma Cell |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
62.5 mg/kg |
10 |
3 |
11 |
93 |
1 |
Hyperplasia |
Minimal, Plasma Cell |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
62.5 mg/kg |
10 |
3 |
12 |
93 |
1 |
Hyperplasia |
Mild, Plasma Cell |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
62.5 mg/kg |
10 |
3 |
13 |
93 |
1 |
Hyperplasia |
Mild, Plasma Cell |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
62.5 mg/kg |
10 |
3 |
14 |
93 |
1 |
Hyperplasia |
Minimal, Plasma Cell |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
62.5 mg/kg |
10 |
3 |
15 |
93 |
1 |
Hyperplasia |
Minimal, Plasma Cell |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
62.5 mg/kg |
10 |
4 |
16 |
93 |
1 |
Hyperplasia |
Minimal, Plasma Cell |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
62.5 mg/kg |
10 |
4 |
17 |
93 |
1 |
Hyperplasia |
Mild, Plasma Cell |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
62.5 mg/kg |
10 |
4 |
18 |
93 |
1 |
Hyperplasia |
Mild, Plasma Cell |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
62.5 mg/kg |
10 |
4 |
19 |
93 |
1 |
Hyperplasia |
Minimal, Plasma Cell |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
62.5 mg/kg |
10 |
4 |
20 |
93 |
1 |
Hyperplasia |
Minimal, Plasma Cell |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
125 mg/kg |
10 |
5 |
21 |
93 |
1 |
Hyperplasia |
Minimal, Plasma Cell |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
125 mg/kg |
10 |
5 |
22 |
93 |
1 |
Hyperplasia |
Mild, Plasma Cell |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
125 mg/kg |
10 |
5 |
23 |
93 |
1 |
Hyperplasia |
Minimal, Plasma Cell |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
125 mg/kg |
10 |
5 |
24 |
93 |
1 |
Hyperplasia |
Minimal, Plasma Cell |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
125 mg/kg |
10 |
5 |
25 |
93 |
1 |
Hyperplasia |
Moderate, Lymphoid |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
125 mg/kg |
10 |
6 |
26 |
93 |
1 |
Hyperplasia |
Mild, Plasma Cell |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
125 mg/kg |
10 |
6 |
27 |
93 |
1 |
Hyperplasia |
Mild, Plasma Cell |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
125 mg/kg |
10 |
6 |
29 |
93 |
1 |
Hyperplasia |
Mild, Plasma Cell |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
125 mg/kg |
10 |
6 |
30 |
93 |
1 |
Hyperplasia |
Mild, Lymphoid |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
250 mg/kg |
10 |
7 |
31 |
93 |
1 |
Hyperplasia |
Minimal, Plasma Cell |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
250 mg/kg |
10 |
7 |
32 |
93 |
1 |
Hyperplasia |
Mild, Plasma Cell |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
250 mg/kg |
10 |
7 |
33 |
93 |
1 |
Hyperplasia |
Minimal, Plasma Cell |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
250 mg/kg |
10 |
7 |
34 |
93 |
1 |
Hyperplasia |
Minimal, Plasma Cell |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
250 mg/kg |
10 |
8 |
36 |
93 |
1 |
Hyperplasia |
Minimal, Plasma Cell |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
250 mg/kg |
10 |
8 |
37 |
93 |
1 |
Hyperplasia |
Mild, Plasma Cell |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
250 mg/kg |
10 |
8 |
38 |
93 |
1 |
Hyperplasia |
Minimal, Plasma Cell |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
250 mg/kg |
10 |
8 |
39 |
93 |
1 |
Hyperplasia |
Minimal, Plasma Cell |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
250 mg/kg |
10 |
8 |
40 |
93 |
1 |
Hyperplasia |
Minimal, Plasma Cell |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
500 mg/kg |
10 |
10 |
46 |
93 |
1 |
Hyperplasia |
Minimal, Plasma Cell |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
500 mg/kg |
10 |
10 |
48 |
93 |
1 |
Hyperplasia |
Minimal, Plasma Cell |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
500 mg/kg |
10 |
10 |
49 |
93 |
1 |
Hyperplasia |
Minimal, Plasma Cell |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
500 mg/kg |
10 |
10 |
50 |
93 |
1 |
Hyperplasia |
Mild, Plasma Cell |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
500 mg/kg |
10 |
9 |
41 |
93 |
1 |
Hyperplasia |
Minimal, Lymphoid |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
500 mg/kg |
10 |
9 |
41 |
93 |
1 |
Hyperplasia |
Mild, Plasma Cell |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
500 mg/kg |
10 |
9 |
43 |
93 |
1 |
Hyperplasia |
Minimal, Plasma Cell |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
500 mg/kg |
10 |
9 |
44 |
93 |
1 |
Hyperplasia |
Mild, Plasma Cell |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
500 mg/kg |
10 |
9 |
45 |
93 |
1 |
Hyperplasia |
Minimal, Plasma Cell |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
1000 mg/kg |
10 |
11 |
51 |
93 |
1 |
Hyperplasia |
Mild, Plasma Cell |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
1000 mg/kg |
10 |
11 |
52 |
93 |
1 |
Hyperplasia |
Minimal, Plasma Cell |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
1000 mg/kg |
10 |
11 |
53 |
93 |
1 |
Hyperplasia |
Minimal, Lymphoid |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
1000 mg/kg |
10 |
11 |
53 |
93 |
1 |
Hyperplasia |
Mild, Plasma Cell |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
1000 mg/kg |
10 |
11 |
54 |
93 |
1 |
Hyperplasia |
Moderate, Plasma Cell |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
1000 mg/kg |
10 |
12 |
56 |
93 |
1 |
Hyperplasia |
Minimal, Plasma Cell |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
1000 mg/kg |
10 |
12 |
57 |
93 |
1 |
Hyperplasia |
Minimal, Plasma Cell |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
1000 mg/kg |
10 |
12 |
58 |
93 |
1 |
Hyperplasia |
Mild, Plasma Cell |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
1000 mg/kg |
10 |
12 |
59 |
93 |
1 |
Hyperplasia |
Mild, Lymphoid |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
1000 mg/kg |
10 |
12 |
60 |
93 |
1 |
Hyperplasia |
Mild, Plasma Cell |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
62.5 mg/kg |
10 |
4 |
18 |
93 |
1 |
Hyperplasia |
Mild, Lymphoid |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
62.5 mg/kg |
10 |
3 |
13 |
93 |
1 |
Infiltration Cellular |
Mild, Histiocyte |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
62.5 mg/kg |
10 |
3 |
14 |
93 |
1 |
Infiltration Cellular |
Mild, Histiocyte |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
125 mg/kg |
10 |
5 |
22 |
93 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
125 mg/kg |
10 |
5 |
24 |
93 |
1 |
Infiltration Cellular |
Mild, Histiocyte |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
125 mg/kg |
10 |
5 |
25 |
93 |
1 |
Infiltration Cellular |
Mild, Histiocyte |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
125 mg/kg |
10 |
6 |
26 |
93 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
125 mg/kg |
10 |
6 |
27 |
93 |
1 |
Infiltration Cellular |
Mild, Histiocyte |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
125 mg/kg |
10 |
6 |
28 |
93 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
250 mg/kg |
10 |
7 |
31 |
93 |
1 |
Infiltration Cellular |
Mild, Histiocyte |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
250 mg/kg |
10 |
7 |
32 |
93 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
250 mg/kg |
10 |
7 |
33 |
93 |
1 |
Infiltration Cellular |
Mild, Histiocyte |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
250 mg/kg |
10 |
7 |
34 |
93 |
1 |
Infiltration Cellular |
Mild, Histiocyte |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
250 mg/kg |
10 |
7 |
35 |
93 |
1 |
Infiltration Cellular |
Mild, Histiocyte |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
250 mg/kg |
10 |
8 |
37 |
93 |
1 |
Infiltration Cellular |
Mild, Histiocyte |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
250 mg/kg |
10 |
8 |
38 |
93 |
1 |
Infiltration Cellular |
Mild, Histiocyte |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
500 mg/kg |
10 |
10 |
47 |
93 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
500 mg/kg |
10 |
10 |
48 |
93 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
500 mg/kg |
10 |
10 |
49 |
93 |
1 |
Infiltration Cellular |
Mild, Histiocyte |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
500 mg/kg |
10 |
10 |
50 |
93 |
1 |
Infiltration Cellular |
Mild, Histiocyte |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
500 mg/kg |
10 |
9 |
41 |
93 |
1 |
Infiltration Cellular |
Mild, Histiocyte |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
500 mg/kg |
10 |
9 |
42 |
93 |
1 |
Infiltration Cellular |
Mild, Histiocyte |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
500 mg/kg |
10 |
9 |
43 |
93 |
1 |
Infiltration Cellular |
Mild, Histiocyte |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
1000 mg/kg |
10 |
11 |
52 |
93 |
1 |
Infiltration Cellular |
Mild, Histiocyte |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
1000 mg/kg |
10 |
11 |
53 |
93 |
1 |
Infiltration Cellular |
Mild, Histiocyte |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
1000 mg/kg |
10 |
11 |
54 |
93 |
1 |
Infiltration Cellular |
Mild, Histiocyte |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
1000 mg/kg |
10 |
11 |
55 |
93 |
1 |
Infiltration Cellular |
Mild, Histiocyte |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
1000 mg/kg |
10 |
12 |
58 |
93 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
1000 mg/kg |
10 |
12 |
59 |
93 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
1000 mg/kg |
10 |
12 |
60 |
93 |
1 |
Infiltration Cellular |
Mild, Histiocyte |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
250 mg/kg |
10 |
7 |
31 |
93 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
1000 mg/kg |
10 |
11 |
51 |
93 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
1000 mg/kg |
10 |
11 |
53 |
93 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
1000 mg/kg |
10 |
11 |
54 |
93 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
1000 mg/kg |
10 |
11 |
55 |
93 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
1000 mg/kg |
10 |
12 |
59 |
93 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Respiratory System |
Lung |
|
Vehicle Control |
10 |
1 |
1 |
93 |
1 |
Hemorrhage |
Minimal |
Terminal Sacrifice |
Respiratory System |
Lung |
|
Vehicle Control |
10 |
1 |
2 |
93 |
1 |
Hemorrhage |
Minimal |
Terminal Sacrifice |
Respiratory System |
Lung |
|
Vehicle Control |
10 |
1 |
3 |
93 |
1 |
Hemorrhage |
Minimal |
Terminal Sacrifice |
Respiratory System |
Lung |
|
Vehicle Control |
10 |
1 |
4 |
93 |
1 |
Hemorrhage |
Mild |
Terminal Sacrifice |
Respiratory System |
Lung |
|
Vehicle Control |
10 |
1 |
5 |
93 |
1 |
Hemorrhage |
Minimal |
Terminal Sacrifice |
Respiratory System |
Lung |
|
Vehicle Control |
10 |
2 |
9 |
93 |
1 |
Hemorrhage |
Minimal |
Terminal Sacrifice |
Respiratory System |
Lung |
|
Vehicle Control |
10 |
1 |
1 |
93 |
1 |
Inflammation |
Mild |
Terminal Sacrifice |
Respiratory System |
Lung |
|
Vehicle Control |
10 |
1 |
2 |
93 |
1 |
Inflammation |
Moderate |
Terminal Sacrifice |
Respiratory System |
Lung |
|
Vehicle Control |
10 |
1 |
3 |
93 |
1 |
Inflammation |
Mild |
Terminal Sacrifice |
Respiratory System |
Lung |
|
Vehicle Control |
10 |
1 |
4 |
93 |
1 |
Inflammation |
Moderate |
Terminal Sacrifice |
Respiratory System |
Lung |
|
Vehicle Control |
10 |
1 |
5 |
93 |
1 |
Inflammation |
Moderate |
Terminal Sacrifice |
Respiratory System |
Lung |
|
Vehicle Control |
10 |
2 |
10 |
93 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Lung |
|
Vehicle Control |
10 |
2 |
6 |
93 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Lung |
|
Vehicle Control |
10 |
2 |
8 |
93 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Lung |
|
Vehicle Control |
10 |
2 |
9 |
93 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Lung |
|
1000 mg/kg |
10 |
11 |
52 |
93 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Lung |
|
1000 mg/kg |
10 |
11 |
53 |
93 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Lung |
|
1000 mg/kg |
10 |
11 |
54 |
93 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Lung |
|
1000 mg/kg |
10 |
11 |
55 |
93 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Lung |
|
1000 mg/kg |
10 |
12 |
58 |
93 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Lung |
|
1000 mg/kg |
10 |
12 |
59 |
93 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Lung |
|
1000 mg/kg |
10 |
12 |
60 |
93 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Glands, Olfactory Epi |
500 mg/kg |
10 |
10 |
46 |
93 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Glands, Olfactory Epi |
500 mg/kg |
10 |
9 |
42 |
93 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Glands, Olfactory Epi |
500 mg/kg |
10 |
9 |
45 |
93 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Glands, Olfactory Epi |
1000 mg/kg |
10 |
11 |
51 |
93 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Glands, Olfactory Epi |
1000 mg/kg |
10 |
11 |
52 |
93 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Glands, Olfactory Epi |
1000 mg/kg |
10 |
11 |
53 |
93 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Glands, Olfactory Epi |
1000 mg/kg |
10 |
11 |
54 |
93 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Glands, Olfactory Epi |
1000 mg/kg |
10 |
12 |
56 |
93 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Glands, Olfactory Epi |
1000 mg/kg |
10 |
12 |
57 |
93 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Glands, Olfactory Epi |
1000 mg/kg |
10 |
12 |
60 |
93 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
1000 mg/kg |
10 |
11 |
51 |
93 |
1 |
Pigmentation |
Mild, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Nose |
Lamina Propria |
1000 mg/kg |
10 |
11 |
52 |
93 |
1 |
Pigmentation |
Mild, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Nose |
Nasopharyn Dct |
500 mg/kg |
10 |
10 |
46 |
93 |
1 |
Degeneration |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Nasopharyn Dct |
500 mg/kg |
10 |
10 |
47 |
93 |
1 |
Degeneration |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Nasopharyn Dct |
500 mg/kg |
10 |
10 |
49 |
93 |
1 |
Degeneration |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Nasopharyn Dct |
1000 mg/kg |
10 |
11 |
53 |
93 |
1 |
Degeneration |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Nasopharyn Dct |
1000 mg/kg |
10 |
12 |
58 |
93 |
1 |
Degeneration |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Nasopharyn Dct |
1000 mg/kg |
10 |
12 |
59 |
93 |
1 |
Degeneration |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Nasopharyn Dct |
500 mg/kg |
10 |
10 |
46 |
93 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Nasopharyn Dct |
500 mg/kg |
10 |
10 |
47 |
93 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Nasopharyn Dct |
1000 mg/kg |
10 |
11 |
53 |
93 |
1 |
Inflammation |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Nasopharyn Dct |
1000 mg/kg |
10 |
12 |
58 |
93 |
1 |
Inflammation |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Nasopharyn Dct |
1000 mg/kg |
10 |
12 |
59 |
93 |
1 |
Inflammation |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
500 mg/kg |
10 |
10 |
46 |
93 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
500 mg/kg |
10 |
10 |
47 |
93 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
500 mg/kg |
10 |
9 |
41 |
93 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
500 mg/kg |
10 |
9 |
42 |
93 |
1 |
Atrophy |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
500 mg/kg |
10 |
9 |
45 |
93 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
1000 mg/kg |
10 |
11 |
51 |
93 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
1000 mg/kg |
10 |
11 |
52 |
93 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
1000 mg/kg |
10 |
11 |
53 |
93 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
1000 mg/kg |
10 |
11 |
54 |
93 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
1000 mg/kg |
10 |
11 |
55 |
93 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
1000 mg/kg |
10 |
12 |
56 |
93 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
1000 mg/kg |
10 |
12 |
57 |
93 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
1000 mg/kg |
10 |
12 |
58 |
93 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
1000 mg/kg |
10 |
12 |
59 |
93 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Nerve |
1000 mg/kg |
10 |
12 |
60 |
93 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
125 mg/kg |
10 |
6 |
28 |
93 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
125 mg/kg |
10 |
6 |
29 |
93 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
250 mg/kg |
10 |
7 |
34 |
93 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
500 mg/kg |
10 |
10 |
46 |
93 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
500 mg/kg |
10 |
10 |
47 |
93 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
500 mg/kg |
10 |
9 |
42 |
93 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
10 |
11 |
51 |
93 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
10 |
11 |
52 |
93 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
10 |
11 |
53 |
93 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
10 |
11 |
54 |
93 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
10 |
12 |
56 |
93 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
10 |
12 |
57 |
93 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
10 |
12 |
58 |
93 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
10 |
12 |
59 |
93 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
10 |
12 |
60 |
93 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
500 mg/kg |
10 |
9 |
42 |
93 |
1 |
Hyperplasia, Basal Cell |
Minimal, Basal Cell |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
10 |
11 |
51 |
93 |
1 |
Hyperplasia, Basal Cell |
Minimal, Basal Cell |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
125 mg/kg |
10 |
6 |
28 |
93 |
1 |
Metaplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
500 mg/kg |
10 |
10 |
46 |
93 |
1 |
Metaplasia |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
500 mg/kg |
10 |
10 |
47 |
93 |
1 |
Metaplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
500 mg/kg |
10 |
10 |
49 |
93 |
1 |
Metaplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
500 mg/kg |
10 |
9 |
41 |
93 |
1 |
Metaplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
500 mg/kg |
10 |
9 |
42 |
93 |
1 |
Metaplasia |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
500 mg/kg |
10 |
9 |
45 |
93 |
1 |
Metaplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
10 |
11 |
51 |
93 |
1 |
Metaplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
10 |
11 |
52 |
93 |
1 |
Metaplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
10 |
11 |
53 |
93 |
1 |
Metaplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
10 |
11 |
54 |
93 |
1 |
Metaplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
10 |
11 |
55 |
93 |
1 |
Metaplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
10 |
12 |
56 |
93 |
1 |
Metaplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
10 |
12 |
57 |
93 |
1 |
Metaplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
10 |
12 |
58 |
93 |
1 |
Metaplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
10 |
12 |
59 |
93 |
1 |
Metaplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
10 |
12 |
60 |
93 |
1 |
Metaplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
500 mg/kg |
10 |
10 |
47 |
93 |
1 |
Necrosis |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
10 |
11 |
51 |
93 |
1 |
Necrosis |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
10 |
12 |
58 |
93 |
1 |
Necrosis |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
10 |
12 |
59 |
93 |
1 |
Necrosis |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
500 mg/kg |
10 |
10 |
46 |
93 |
1 |
Pigmentation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
500 mg/kg |
10 |
10 |
47 |
93 |
1 |
Pigmentation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
500 mg/kg |
10 |
9 |
41 |
93 |
1 |
Pigmentation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
500 mg/kg |
10 |
9 |
42 |
93 |
1 |
Pigmentation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
10 |
11 |
51 |
93 |
1 |
Pigmentation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
10 |
11 |
52 |
93 |
1 |
Pigmentation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
10 |
11 |
53 |
93 |
1 |
Pigmentation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
10 |
12 |
57 |
93 |
1 |
Pigmentation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
10 |
12 |
60 |
93 |
1 |
Pigmentation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
1000 mg/kg |
10 |
12 |
58 |
93 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
Vehicle Control |
10 |
2 |
8 |
93 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
500 mg/kg |
10 |
10 |
46 |
93 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
500 mg/kg |
10 |
10 |
47 |
93 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
1000 mg/kg |
10 |
11 |
53 |
93 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
1000 mg/kg |
10 |
11 |
54 |
93 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
1000 mg/kg |
10 |
12 |
56 |
93 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
1000 mg/kg |
10 |
12 |
59 |
93 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
1000 mg/kg |
10 |
12 |
56 |
93 |
1 |
Metaplasia |
Minimal, Squamous |
Terminal Sacrifice |
Respiratory System |
Nose |
Respirat Epith |
1000 mg/kg |
10 |
12 |
58 |
93 |
1 |
Necrosis |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
|
Vehicle Control |
10 |
1 |
2 |
93 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
|
Vehicle Control |
10 |
1 |
3 |
93 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
|
62.5 mg/kg |
10 |
3 |
14 |
93 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
|
62.5 mg/kg |
10 |
4 |
17 |
93 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
|
62.5 mg/kg |
10 |
4 |
20 |
93 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
|
125 mg/kg |
10 |
5 |
22 |
93 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
|
250 mg/kg |
10 |
7 |
33 |
93 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
|
250 mg/kg |
10 |
8 |
39 |
93 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
|
500 mg/kg |
10 |
10 |
47 |
93 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
|
500 mg/kg |
10 |
10 |
49 |
93 |
1 |
Inflammation |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
|
500 mg/kg |
10 |
9 |
44 |
93 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
|
1000 mg/kg |
10 |
11 |
52 |
93 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
|
1000 mg/kg |
10 |
11 |
53 |
93 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
|
1000 mg/kg |
10 |
12 |
56 |
93 |
1 |
Inflammation |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
|
1000 mg/kg |
10 |
12 |
58 |
93 |
1 |
Inflammation |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
|
1000 mg/kg |
10 |
12 |
59 |
93 |
1 |
Inflammation |
Moderate |
Terminal Sacrifice |
Respiratory System |
Trachea |
|
Vehicle Control |
10 |
2 |
10 |
93 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Special Senses System |
Harderian Gland |
|
Vehicle Control |
10 |
1 |
1 |
93 |
1 |
Inflammation |
Mild |
Terminal Sacrifice |
Urinary System |
Kidney |
|
1000 mg/kg |
10 |
12 |
56 |
93 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
1000 mg/kg |
10 |
12 |
58 |
93 |
1 |
Mineralization |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
1 |
1 |
93 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
1 |
3 |
93 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
1 |
4 |
93 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
1 |
5 |
93 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
2 |
10 |
93 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
2 |
6 |
93 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
2 |
8 |
93 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
2 |
9 |
93 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
1000 mg/kg |
10 |
11 |
55 |
93 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
1000 mg/kg |
10 |
12 |
56 |
93 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
1000 mg/kg |
10 |
12 |
57 |
93 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
1000 mg/kg |
10 |
12 |
58 |
93 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
1000 mg/kg |
10 |
12 |
59 |
93 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |