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Short-Term Individual Animal Non Neoplastic Diagnosis
Study Information:
Chemical Name: | Pentabromodiphenyl Oxide (Technical) (DE 71) |
CASRN: | ="32534-81-9" |
Study Number: | C20209 |
Exposure Route: | GAVAGE |
TDMS Number: | 2020902 |
Sex: | Female |
Strain and Species: | B6C3F1 Mice |
Female Individual Animal Non Neoplastic Diagnoses
System |
Organ |
Site |
Treatment Group |
Number Examined |
Cage Number |
Animal Number |
Days on Study |
Lesion Found |
Lesion Name |
Lesion Qualifier |
Removal Reason |
Alimentary System |
Esophagus |
|
50 MG/KG |
10 |
67 |
91 |
7 |
1 |
Foreign Body |
|
Dosing Accident |
Alimentary System |
Esophagus |
|
Vehicle Control |
10 |
62 |
70 |
5 |
1 |
Inflammation |
Minimal |
Dosing Accident |
Alimentary System |
Esophagus |
|
Vehicle Control |
10 |
61 |
65 |
93 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Alimentary System |
Esophagus |
|
Vehicle Control |
10 |
62 |
68 |
93 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Alimentary System |
Esophagus |
|
50 MG/KG |
10 |
67 |
91 |
7 |
1 |
Inflammation |
Marked |
Dosing Accident |
Alimentary System |
Esophagus |
|
50 MG/KG |
10 |
67 |
93 |
93 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Alimentary System |
Esophagus |
|
50 MG/KG |
10 |
67 |
95 |
93 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Alimentary System |
Esophagus |
|
50 MG/KG |
10 |
68 |
100 |
93 |
1 |
Inflammation |
Moderate |
Terminal Sacrifice |
Alimentary System |
Esophagus |
|
50 MG/KG |
10 |
68 |
96 |
93 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Alimentary System |
Esophagus |
|
50 MG/KG |
10 |
68 |
97 |
93 |
1 |
Inflammation |
Mild |
Terminal Sacrifice |
Alimentary System |
Esophagus |
|
50 MG/KG |
10 |
68 |
99 |
93 |
1 |
Inflammation |
Mild |
Terminal Sacrifice |
Alimentary System |
Esophagus |
|
100 MG/KG |
10 |
70 |
106 |
5 |
1 |
Inflammation |
Moderate |
Dosing Accident |
Alimentary System |
Esophagus |
|
500 MG/KG |
10 |
71 |
111 |
6 |
1 |
Inflammation |
Moderate |
Dosing Accident |
Alimentary System |
Esophagus |
|
500 MG/KG |
10 |
71 |
113 |
93 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Alimentary System |
Esophagus |
|
500 MG/KG |
10 |
71 |
115 |
93 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Alimentary System |
Esophagus |
|
500 MG/KG |
10 |
72 |
118 |
4 |
1 |
Perforation |
|
Dosing Accident |
Alimentary System |
Liver |
Hepatocyte |
100 MG/KG |
10 |
69 |
101 |
93 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
100 MG/KG |
10 |
69 |
102 |
93 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
100 MG/KG |
10 |
69 |
103 |
93 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
100 MG/KG |
10 |
69 |
104 |
93 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
100 MG/KG |
10 |
69 |
105 |
93 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
100 MG/KG |
10 |
70 |
107 |
93 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
100 MG/KG |
10 |
70 |
108 |
93 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
100 MG/KG |
10 |
70 |
109 |
93 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
100 MG/KG |
10 |
70 |
110 |
93 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
500 MG/KG |
10 |
71 |
112 |
79 |
1 |
Hypertrophy |
Mild |
Moribund Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
500 MG/KG |
10 |
71 |
113 |
93 |
1 |
Hypertrophy |
Moderate |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
500 MG/KG |
10 |
71 |
114 |
93 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
500 MG/KG |
10 |
71 |
115 |
93 |
1 |
Hypertrophy |
Moderate |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
500 MG/KG |
10 |
72 |
116 |
93 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
500 MG/KG |
10 |
72 |
117 |
93 |
1 |
Hypertrophy |
Moderate |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
500 MG/KG |
10 |
71 |
112 |
79 |
1 |
Necrosis |
Mild |
Moribund Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
500 MG/KG |
10 |
71 |
113 |
93 |
1 |
Necrosis |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
500 MG/KG |
10 |
71 |
114 |
93 |
1 |
Necrosis |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
500 MG/KG |
10 |
71 |
115 |
93 |
1 |
Necrosis |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
500 MG/KG |
10 |
72 |
116 |
93 |
1 |
Necrosis |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
500 MG/KG |
10 |
72 |
117 |
93 |
1 |
Necrosis |
Minimal |
Terminal Sacrifice |
Alimentary System |
Salivary Glands |
|
500 MG/KG |
10 |
71 |
115 |
93 |
1 |
Hyperplasia |
Minimal, Lymphoid |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach |
500 MG/KG |
10 |
71 |
112 |
79 |
1 |
Ulcer |
Mild |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
500 MG/KG |
10 |
71 |
112 |
79 |
1 |
Hyperplasia |
Moderate |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
500 MG/KG |
10 |
72 |
119 |
32 |
1 |
Hyperplasia |
Mild |
Natural Death |
Alimentary System |
Stomach |
Glandular |
500 MG/KG |
10 |
71 |
112 |
79 |
1 |
Erosion |
Minimal |
Moribund Sacrifice |
Cardiovascular System |
Heart |
|
500 MG/KG |
10 |
71 |
111 |
6 |
1 |
Mineralization |
Minimal |
Dosing Accident |
Endocrine System |
Adrenal Cortex |
|
500 MG/KG |
10 |
71 |
112 |
79 |
1 |
Degeneration |
Minimal, Fatty |
Moribund Sacrifice |
Endocrine System |
Adrenal Cortex |
|
500 MG/KG |
10 |
72 |
119 |
32 |
1 |
Degeneration |
Moderate, Fatty |
Natural Death |
Endocrine System |
Thyroid Gland |
Follicle |
100 MG/KG |
10 |
69 |
103 |
93 |
1 |
Cyst |
|
Terminal Sacrifice |
Genital System |
Ovary |
|
0.01 MG/KG |
1 |
64 |
76 |
93 |
1 |
Cyst |
|
Terminal Sacrifice |
Genital System |
Uterus |
Endometrial Gl |
Vehicle Control |
10 |
61 |
65 |
93 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Bone Marrow |
|
Vehicle Control |
10 |
62 |
70 |
5 |
1 |
Hyperplasia |
Mild |
Dosing Accident |
Hematopoietic System |
Bone Marrow |
|
50 MG/KG |
1 |
67 |
91 |
7 |
1 |
Hyperplasia |
Mild |
Dosing Accident |
Hematopoietic System |
Bone Marrow |
|
500 MG/KG |
10 |
71 |
111 |
6 |
1 |
Hyperplasia |
Mild |
Dosing Accident |
Hematopoietic System |
Lymph Node |
Mandibular |
500 MG/KG |
10 |
72 |
116 |
93 |
1 |
Hemorrhage |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
Vehicle Control |
10 |
62 |
69 |
93 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mesenteric |
100 MG/KG |
10 |
69 |
105 |
93 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
Lymph Follic |
Vehicle Control |
10 |
62 |
70 |
5 |
1 |
Atrophy |
Minimal |
Dosing Accident |
Hematopoietic System |
Spleen |
Lymph Follic |
100 MG/KG |
10 |
70 |
106 |
5 |
1 |
Atrophy |
Minimal |
Dosing Accident |
Hematopoietic System |
Spleen |
Lymph Follic |
500 MG/KG |
10 |
72 |
118 |
4 |
1 |
Atrophy |
Moderate |
Dosing Accident |
Hematopoietic System |
Spleen |
Lymph Follic |
500 MG/KG |
10 |
71 |
115 |
93 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
50 MG/KG |
10 |
67 |
91 |
7 |
1 |
Atrophy |
Mild |
Dosing Accident |
Hematopoietic System |
Thymus |
|
500 MG/KG |
10 |
72 |
118 |
4 |
1 |
Atrophy |
Moderate |
Dosing Accident |
Hematopoietic System |
Thymus |
|
500 MG/KG |
10 |
71 |
112 |
79 |
1 |
Atrophy |
Marked |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
500 MG/KG |
10 |
72 |
119 |
32 |
1 |
Atrophy |
Moderate |
Natural Death |
Integumentary System |
Skin |
Subcut Tiss |
100 MG/KG |
10 |
69 |
101 |
93 |
1 |
Proliferation Connective Tissue |
Mild |
Terminal Sacrifice |
Respiratory System |
Lung |
|
50 MG/KG |
10 |
67 |
91 |
7 |
1 |
Foreign Body |
|
Dosing Accident |
Respiratory System |
Lung |
|
5 MG/KG |
10 |
66 |
87 |
93 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Lung |
|
50 MG/KG |
10 |
67 |
91 |
7 |
1 |
Inflammation |
Marked |
Dosing Accident |
Respiratory System |
Lung |
|
50 MG/KG |
10 |
67 |
95 |
93 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
|
500 MG/KG |
10 |
71 |
112 |
79 |
1 |
Inflammation |
Minimal, Chronic |
Moribund Sacrifice |
Respiratory System |
Pleura |
|
Vehicle Control |
10 |
62 |
70 |
5 |
1 |
Foreign Body |
|
Dosing Accident |
Respiratory System |
Pleura |
|
5 MG/KG |
10 |
66 |
89 |
93 |
1 |
Foreign Body |
|
Terminal Sacrifice |
Respiratory System |
Pleura |
|
Vehicle Control |
10 |
62 |
70 |
5 |
1 |
Inflammation |
Marked |
Dosing Accident |
Respiratory System |
Pleura |
|
5 MG/KG |
10 |
66 |
89 |
93 |
1 |
Inflammation |
Marked |
Terminal Sacrifice |
Respiratory System |
Pleura |
|
50 MG/KG |
10 |
67 |
91 |
7 |
1 |
Inflammation |
Marked |
Dosing Accident |
Respiratory System |
Pleura |
|
50 MG/KG |
10 |
68 |
98 |
93 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Pleura |
|
100 MG/KG |
10 |
70 |
106 |
5 |
1 |
Inflammation |
Marked |
Dosing Accident |
Respiratory System |
Pleura |
|
500 MG/KG |
10 |
71 |
111 |
6 |
1 |
Inflammation |
Marked |
Dosing Accident |
Respiratory System |
Pleura |
|
500 MG/KG |
10 |
72 |
118 |
4 |
1 |
Inflammation |
Marked |
Dosing Accident |
Respiratory System |
Pleura |
|
500 MG/KG |
10 |
72 |
120 |
4 |
1 |
Inflammation |
Moderate |
Dosing Accident |