Alimentary System |
Liver |
Hepatocyte |
5 MG/KG |
10 |
5 |
21 |
93 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
5 MG/KG |
10 |
5 |
22 |
93 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
5 MG/KG |
10 |
5 |
23 |
93 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
5 MG/KG |
10 |
5 |
24 |
93 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
5 MG/KG |
10 |
5 |
25 |
93 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
5 MG/KG |
10 |
6 |
26 |
93 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
5 MG/KG |
10 |
6 |
27 |
93 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
5 MG/KG |
10 |
6 |
28 |
93 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
5 MG/KG |
10 |
6 |
29 |
93 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
50 MG/KG |
10 |
7 |
31 |
93 |
1 |
Hypertrophy |
Moderate |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
50 MG/KG |
10 |
7 |
32 |
93 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
50 MG/KG |
10 |
7 |
33 |
93 |
1 |
Hypertrophy |
Moderate |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
50 MG/KG |
10 |
7 |
34 |
93 |
1 |
Hypertrophy |
Moderate |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
50 MG/KG |
10 |
7 |
35 |
93 |
1 |
Hypertrophy |
Moderate |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
50 MG/KG |
10 |
8 |
36 |
93 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
50 MG/KG |
10 |
8 |
37 |
93 |
1 |
Hypertrophy |
Moderate |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
50 MG/KG |
10 |
8 |
38 |
93 |
1 |
Hypertrophy |
Moderate |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
50 MG/KG |
10 |
8 |
39 |
93 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
50 MG/KG |
10 |
8 |
40 |
93 |
1 |
Hypertrophy |
Moderate |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
100 MG/KG |
10 |
10 |
46 |
93 |
1 |
Hypertrophy |
Moderate |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
100 MG/KG |
10 |
10 |
47 |
93 |
1 |
Hypertrophy |
Moderate |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
100 MG/KG |
10 |
10 |
48 |
93 |
1 |
Hypertrophy |
Moderate |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
100 MG/KG |
10 |
10 |
49 |
93 |
1 |
Hypertrophy |
Marked |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
100 MG/KG |
10 |
10 |
50 |
93 |
1 |
Hypertrophy |
Moderate |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
100 MG/KG |
10 |
9 |
41 |
93 |
1 |
Hypertrophy |
Marked |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
100 MG/KG |
10 |
9 |
42 |
93 |
1 |
Hypertrophy |
Marked |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
100 MG/KG |
10 |
9 |
43 |
93 |
1 |
Hypertrophy |
Moderate |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
100 MG/KG |
10 |
9 |
44 |
93 |
1 |
Hypertrophy |
Moderate |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
100 MG/KG |
10 |
9 |
45 |
93 |
1 |
Hypertrophy |
Marked |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
500 MG/KG |
10 |
11 |
51 |
93 |
1 |
Hypertrophy |
Marked |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
500 MG/KG |
10 |
11 |
52 |
93 |
1 |
Hypertrophy |
Marked |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
500 MG/KG |
10 |
11 |
53 |
93 |
1 |
Hypertrophy |
Marked |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
500 MG/KG |
10 |
11 |
54 |
93 |
1 |
Hypertrophy |
Marked |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
500 MG/KG |
10 |
11 |
55 |
93 |
1 |
Hypertrophy |
Marked |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
500 MG/KG |
10 |
12 |
56 |
93 |
1 |
Hypertrophy |
Marked |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
500 MG/KG |
10 |
12 |
57 |
93 |
1 |
Hypertrophy |
Moderate |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
500 MG/KG |
10 |
12 |
58 |
93 |
1 |
Hypertrophy |
Moderate |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
500 MG/KG |
10 |
12 |
59 |
93 |
1 |
Hypertrophy |
Moderate |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
500 MG/KG |
10 |
12 |
60 |
93 |
1 |
Hypertrophy |
Marked |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
50 MG/KG |
10 |
7 |
31 |
93 |
1 |
Vacuolization Cytoplasmic |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
50 MG/KG |
10 |
7 |
32 |
93 |
1 |
Vacuolization Cytoplasmic |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
50 MG/KG |
10 |
7 |
33 |
93 |
1 |
Vacuolization Cytoplasmic |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
50 MG/KG |
10 |
7 |
34 |
93 |
1 |
Vacuolization Cytoplasmic |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
50 MG/KG |
10 |
7 |
35 |
93 |
1 |
Vacuolization Cytoplasmic |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
50 MG/KG |
10 |
8 |
36 |
93 |
1 |
Vacuolization Cytoplasmic |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
50 MG/KG |
10 |
8 |
37 |
93 |
1 |
Vacuolization Cytoplasmic |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
50 MG/KG |
10 |
8 |
38 |
93 |
1 |
Vacuolization Cytoplasmic |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
50 MG/KG |
10 |
8 |
39 |
93 |
1 |
Vacuolization Cytoplasmic |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
50 MG/KG |
10 |
8 |
40 |
93 |
1 |
Vacuolization Cytoplasmic |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
100 MG/KG |
10 |
10 |
46 |
93 |
1 |
Vacuolization Cytoplasmic |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
100 MG/KG |
10 |
10 |
47 |
93 |
1 |
Vacuolization Cytoplasmic |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
100 MG/KG |
10 |
10 |
48 |
93 |
1 |
Vacuolization Cytoplasmic |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
100 MG/KG |
10 |
10 |
49 |
93 |
1 |
Vacuolization Cytoplasmic |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
100 MG/KG |
10 |
10 |
50 |
93 |
1 |
Vacuolization Cytoplasmic |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
100 MG/KG |
10 |
9 |
41 |
93 |
1 |
Vacuolization Cytoplasmic |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
100 MG/KG |
10 |
9 |
42 |
93 |
1 |
Vacuolization Cytoplasmic |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
100 MG/KG |
10 |
9 |
43 |
93 |
1 |
Vacuolization Cytoplasmic |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
100 MG/KG |
10 |
9 |
44 |
93 |
1 |
Vacuolization Cytoplasmic |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
100 MG/KG |
10 |
9 |
45 |
93 |
1 |
Vacuolization Cytoplasmic |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
500 MG/KG |
10 |
11 |
51 |
93 |
1 |
Vacuolization Cytoplasmic |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
500 MG/KG |
10 |
11 |
52 |
93 |
1 |
Vacuolization Cytoplasmic |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
500 MG/KG |
10 |
11 |
53 |
93 |
1 |
Vacuolization Cytoplasmic |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
500 MG/KG |
10 |
11 |
54 |
93 |
1 |
Vacuolization Cytoplasmic |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
500 MG/KG |
10 |
11 |
55 |
93 |
1 |
Vacuolization Cytoplasmic |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
500 MG/KG |
10 |
12 |
56 |
93 |
1 |
Vacuolization Cytoplasmic |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
500 MG/KG |
10 |
12 |
57 |
93 |
1 |
Vacuolization Cytoplasmic |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
500 MG/KG |
10 |
12 |
58 |
93 |
1 |
Vacuolization Cytoplasmic |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
500 MG/KG |
10 |
12 |
59 |
93 |
1 |
Vacuolization Cytoplasmic |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
500 MG/KG |
10 |
12 |
60 |
93 |
1 |
Vacuolization Cytoplasmic |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
|
5 MG/KG |
10 |
5 |
23 |
93 |
1 |
Hepatodiaphragmatic Nodule |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
50 MG/KG |
10 |
8 |
40 |
93 |
1 |
Hepatodiaphragmatic Nodule |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 MG/KG |
10 |
12 |
59 |
93 |
1 |
Hepatodiaphragmatic Nodule |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
50 MG/KG |
10 |
7 |
34 |
93 |
1 |
Necrosis |
Minimal, Focal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 MG/KG |
10 |
10 |
47 |
93 |
1 |
Necrosis |
Minimal, Focal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 MG/KG |
10 |
10 |
48 |
93 |
1 |
Necrosis |
Minimal, Focal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 MG/KG |
10 |
12 |
58 |
93 |
1 |
Necrosis |
Minimal, Focal |
Terminal Sacrifice |
Alimentary System |
Salivary Glands |
|
500 MG/KG |
10 |
11 |
51 |
93 |
1 |
Necrosis |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Glandular |
5 MG/KG |
10 |
5 |
24 |
93 |
1 |
Erosion |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Glandular |
50 MG/KG |
10 |
7 |
35 |
93 |
1 |
Erosion |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Glandular |
50 MG/KG |
10 |
8 |
39 |
93 |
1 |
Erosion |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Glandular |
100 MG/KG |
10 |
10 |
47 |
93 |
1 |
Erosion |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Glandular |
100 MG/KG |
10 |
10 |
48 |
93 |
1 |
Erosion |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Glandular |
100 MG/KG |
10 |
10 |
49 |
93 |
1 |
Erosion |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Glandular |
500 MG/KG |
10 |
11 |
51 |
93 |
1 |
Erosion |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Glandular |
500 MG/KG |
10 |
11 |
53 |
93 |
1 |
Erosion |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Glandular |
500 MG/KG |
10 |
11 |
54 |
93 |
1 |
Erosion |
Mild |
Terminal Sacrifice |
Alimentary System |
Stomach |
Glandular |
500 MG/KG |
10 |
12 |
57 |
93 |
1 |
Erosion |
Mild |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
10 |
1 |
1 |
93 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
10 |
1 |
4 |
93 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
10 |
2 |
6 |
93 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Endocrine System |
Pituitary Gland |
Pars Distalis |
Vehicle Control |
10 |
2 |
8 |
93 |
1 |
Cyst |
|
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
Follicle |
100 MG/KG |
10 |
10 |
47 |
93 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
Follicle |
500 MG/KG |
10 |
11 |
51 |
93 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
Follicle |
500 MG/KG |
10 |
11 |
52 |
93 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
Follicle |
500 MG/KG |
10 |
11 |
54 |
93 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
Follicle |
500 MG/KG |
10 |
11 |
55 |
93 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
Follicle |
500 MG/KG |
10 |
12 |
56 |
93 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
Follicle |
500 MG/KG |
10 |
12 |
57 |
93 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
Follicle |
500 MG/KG |
10 |
12 |
58 |
93 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
Follicle |
500 MG/KG |
10 |
12 |
59 |
93 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Endocrine System |
Thyroid Gland |
Follicle |
500 MG/KG |
10 |
12 |
60 |
93 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Genital System |
Epididymis |
|
500 MG/KG |
10 |
11 |
51 |
93 |
1 |
Hypospermia |
Minimal |
Terminal Sacrifice |
Genital System |
Epididymis |
|
500 MG/KG |
10 |
11 |
52 |
93 |
1 |
Hypospermia |
Mild |
Terminal Sacrifice |
Genital System |
Epididymis |
|
500 MG/KG |
10 |
11 |
54 |
93 |
1 |
Hypospermia |
Mild |
Terminal Sacrifice |
Genital System |
Epididymis |
|
500 MG/KG |
10 |
11 |
55 |
93 |
1 |
Hypospermia |
Mild |
Terminal Sacrifice |
Genital System |
Epididymis |
|
500 MG/KG |
10 |
12 |
56 |
93 |
1 |
Hypospermia |
Mild |
Terminal Sacrifice |
Genital System |
Epididymis |
|
500 MG/KG |
10 |
12 |
57 |
93 |
1 |
Hypospermia |
Mild |
Terminal Sacrifice |
Genital System |
Epididymis |
|
500 MG/KG |
10 |
12 |
58 |
93 |
1 |
Hypospermia |
Mild |
Terminal Sacrifice |
Genital System |
Epididymis |
|
500 MG/KG |
10 |
12 |
59 |
93 |
1 |
Hypospermia |
Mild |
Terminal Sacrifice |
Genital System |
Epididymis |
|
500 MG/KG |
10 |
12 |
60 |
93 |
1 |
Hypospermia |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Bone Marrow |
|
500 MG/KG |
10 |
11 |
51 |
93 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Bone Marrow |
|
500 MG/KG |
10 |
12 |
59 |
93 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mediastinal |
50 MG/KG |
10 |
7 |
31 |
93 |
1 |
Hemorrhage |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mediastinal |
100 MG/KG |
10 |
9 |
42 |
93 |
1 |
Hemorrhage |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mediastinal |
50 MG/KG |
10 |
7 |
31 |
93 |
1 |
Hyperplasia |
Mild, Lymphoid |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mediastinal |
100 MG/KG |
10 |
9 |
42 |
93 |
1 |
Hyperplasia |
Marked, Lymphoid |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Pancreatic |
0.01 MG/KG |
10 |
3 |
14 |
93 |
1 |
Hemorrhage |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Pancreatic |
0.01 MG/KG |
10 |
3 |
14 |
93 |
1 |
Hyperplasia |
Minimal, Lymphoid |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
Vehicle Control |
10 |
1 |
4 |
93 |
1 |
Hemorrhage |
Minimal |
Terminal Sacrifice |
Hematopoietic System |
Thymus |
|
100 MG/KG |
10 |
9 |
42 |
93 |
1 |
Hemorrhage |
Mild |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolar Epith |
500 MG/KG |
10 |
11 |
51 |
93 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Respiratory System |
Lung |
|
100 MG/KG |
10 |
9 |
43 |
93 |
1 |
Hemorrhage |
Minimal |
Terminal Sacrifice |
Respiratory System |
Lung |
|
100 MG/KG |
10 |
9 |
43 |
93 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
|
500 MG/KG |
10 |
12 |
60 |
93 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
|
Vehicle Control |
10 |
1 |
1 |
93 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Respiratory System |
Lung |
|
Vehicle Control |
10 |
2 |
9 |
93 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Special Senses System |
Harderian Gland |
|
Vehicle Control |
10 |
2 |
10 |
93 |
1 |
Inflammation |
Mild, Chronic |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
1 |
3 |
93 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
500 MG/KG |
10 |
11 |
51 |
93 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
500 MG/KG |
10 |
12 |
57 |
93 |
1 |
Nephropathy |
Minimal |
Terminal Sacrifice |