Alimentary System |
Esophagus |
|
50 MG/KG |
10 |
34 |
34 |
93 |
1 |
Inflammation |
Mild |
Terminal Sacrifice |
Alimentary System |
Esophagus |
|
50 MG/KG |
10 |
36 |
36 |
93 |
1 |
Inflammation |
Mild |
Terminal Sacrifice |
Alimentary System |
Esophagus |
|
50 MG/KG |
10 |
37 |
37 |
93 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Alimentary System |
Esophagus |
|
50 MG/KG |
10 |
39 |
39 |
93 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Alimentary System |
Esophagus |
|
50 MG/KG |
10 |
40 |
40 |
93 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Alimentary System |
Esophagus |
|
500 MG/KG |
10 |
60 |
60 |
34 |
1 |
Inflammation |
Minimal |
Natural Death |
Alimentary System |
Esophagus |
|
500 MG/KG |
10 |
57 |
57 |
93 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Alimentary System |
Intestine Small |
Ileum |
5 MG/KG |
1 |
23 |
23 |
93 |
1 |
Diverticulum |
|
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
5 MG/KG |
10 |
22 |
22 |
93 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
50 MG/KG |
10 |
31 |
31 |
93 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
50 MG/KG |
10 |
32 |
32 |
93 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
50 MG/KG |
10 |
33 |
33 |
93 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
50 MG/KG |
10 |
34 |
34 |
93 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
50 MG/KG |
10 |
35 |
35 |
93 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
50 MG/KG |
10 |
36 |
36 |
93 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
50 MG/KG |
10 |
37 |
37 |
93 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
50 MG/KG |
10 |
38 |
38 |
93 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
50 MG/KG |
10 |
39 |
39 |
93 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
50 MG/KG |
10 |
40 |
40 |
93 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
100 MG/KG |
10 |
41 |
41 |
93 |
1 |
Hypertrophy |
Moderate |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
100 MG/KG |
10 |
42 |
42 |
93 |
1 |
Hypertrophy |
Moderate |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
100 MG/KG |
10 |
43 |
43 |
93 |
1 |
Hypertrophy |
Moderate |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
100 MG/KG |
10 |
44 |
44 |
93 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
100 MG/KG |
10 |
45 |
45 |
93 |
1 |
Hypertrophy |
Moderate |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
100 MG/KG |
10 |
46 |
46 |
93 |
1 |
Hypertrophy |
Moderate |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
100 MG/KG |
10 |
47 |
47 |
93 |
1 |
Hypertrophy |
Moderate |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
100 MG/KG |
10 |
48 |
48 |
93 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
100 MG/KG |
10 |
49 |
49 |
93 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
100 MG/KG |
10 |
50 |
50 |
93 |
1 |
Hypertrophy |
Moderate |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
500 MG/KG |
10 |
54 |
54 |
79 |
1 |
Hypertrophy |
Marked |
Moribund Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
500 MG/KG |
10 |
55 |
55 |
66 |
1 |
Hypertrophy |
Moderate |
Moribund Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
500 MG/KG |
10 |
56 |
56 |
59 |
1 |
Hypertrophy |
Moderate |
Moribund Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
500 MG/KG |
10 |
51 |
51 |
27 |
1 |
Hypertrophy |
Mild |
Natural Death |
Alimentary System |
Liver |
Hepatocyte |
500 MG/KG |
10 |
52 |
52 |
26 |
1 |
Hypertrophy |
Mild |
Natural Death |
Alimentary System |
Liver |
Hepatocyte |
500 MG/KG |
10 |
58 |
58 |
33 |
1 |
Hypertrophy |
Moderate |
Natural Death |
Alimentary System |
Liver |
Hepatocyte |
500 MG/KG |
10 |
60 |
60 |
34 |
1 |
Hypertrophy |
Mild |
Natural Death |
Alimentary System |
Liver |
Hepatocyte |
500 MG/KG |
10 |
53 |
53 |
93 |
1 |
Hypertrophy |
Marked |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
500 MG/KG |
10 |
57 |
57 |
93 |
1 |
Hypertrophy |
Marked |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
500 MG/KG |
10 |
59 |
59 |
93 |
1 |
Hypertrophy |
Marked |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
100 MG/KG |
10 |
43 |
43 |
93 |
1 |
Necrosis |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
500 MG/KG |
10 |
54 |
54 |
79 |
1 |
Necrosis |
Mild |
Moribund Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
500 MG/KG |
10 |
55 |
55 |
66 |
1 |
Necrosis |
Minimal |
Moribund Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
500 MG/KG |
10 |
56 |
56 |
59 |
1 |
Necrosis |
Mild |
Moribund Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
500 MG/KG |
10 |
51 |
51 |
27 |
1 |
Necrosis |
Minimal |
Natural Death |
Alimentary System |
Liver |
Hepatocyte |
500 MG/KG |
10 |
52 |
52 |
26 |
1 |
Necrosis |
Minimal |
Natural Death |
Alimentary System |
Liver |
Hepatocyte |
500 MG/KG |
10 |
58 |
58 |
33 |
1 |
Necrosis |
Minimal |
Natural Death |
Alimentary System |
Liver |
Hepatocyte |
500 MG/KG |
10 |
60 |
60 |
34 |
1 |
Necrosis |
Minimal |
Natural Death |
Alimentary System |
Liver |
Hepatocyte |
500 MG/KG |
10 |
53 |
53 |
93 |
1 |
Necrosis |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
500 MG/KG |
10 |
57 |
57 |
93 |
1 |
Necrosis |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
500 MG/KG |
10 |
59 |
59 |
93 |
1 |
Necrosis |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
500 MG/KG |
10 |
54 |
54 |
79 |
1 |
Vacuolization Cytoplasmic |
Minimal |
Moribund Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
500 MG/KG |
10 |
55 |
55 |
66 |
1 |
Vacuolization Cytoplasmic |
Minimal |
Moribund Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
500 MG/KG |
10 |
56 |
56 |
59 |
1 |
Vacuolization Cytoplasmic |
Mild |
Moribund Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
500 MG/KG |
10 |
53 |
53 |
93 |
1 |
Vacuolization Cytoplasmic |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
500 MG/KG |
10 |
57 |
57 |
93 |
1 |
Vacuolization Cytoplasmic |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
500 MG/KG |
10 |
59 |
59 |
93 |
1 |
Vacuolization Cytoplasmic |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
100 MG/KG |
10 |
47 |
47 |
93 |
1 |
Infarct |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 MG/KG |
10 |
54 |
54 |
79 |
1 |
Necrosis |
Mild, Focal |
Moribund Sacrifice |
Alimentary System |
Liver |
|
500 MG/KG |
10 |
56 |
56 |
59 |
1 |
Necrosis |
Mild, Focal |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach |
500 MG/KG |
10 |
54 |
54 |
79 |
1 |
Erosion |
Marked |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach |
500 MG/KG |
10 |
56 |
56 |
59 |
1 |
Inflammation |
Mild, Chronic |
Moribund Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
5 MG/KG |
10 |
25 |
25 |
93 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
50 MG/KG |
10 |
39 |
39 |
93 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach |
Forestomach, Epithelium |
500 MG/KG |
10 |
54 |
54 |
79 |
1 |
Hyperplasia |
Moderate |
Moribund Sacrifice |
Alimentary System |
Stomach |
Glandular |
500 MG/KG |
10 |
54 |
54 |
79 |
1 |
Erosion |
Moderate |
Moribund Sacrifice |
Alimentary System |
Stomach |
Glandular |
500 MG/KG |
10 |
56 |
56 |
59 |
1 |
Erosion |
Mild |
Moribund Sacrifice |
Endocrine System |
Adrenal Cortex |
Zona Fascult |
500 MG/KG |
10 |
54 |
54 |
79 |
1 |
Hypertrophy |
Minimal |
Moribund Sacrifice |
Endocrine System |
Adrenal Cortex |
Zona Fascult |
500 MG/KG |
10 |
51 |
51 |
27 |
1 |
Hypertrophy |
Minimal |
Natural Death |
Endocrine System |
Adrenal Cortex |
Zona Fascult |
500 MG/KG |
10 |
52 |
52 |
26 |
1 |
Hypertrophy |
Minimal |
Natural Death |
Endocrine System |
Adrenal Cortex |
Zona Fascult |
500 MG/KG |
10 |
58 |
58 |
33 |
1 |
Hypertrophy |
Minimal |
Natural Death |
Endocrine System |
Adrenal Cortex |
Zona Fascult |
500 MG/KG |
10 |
60 |
60 |
34 |
1 |
Hypertrophy |
Minimal |
Natural Death |
Endocrine System |
Adrenal Cortex |
|
500 MG/KG |
10 |
54 |
54 |
79 |
1 |
Degeneration |
Minimal, Fatty |
Moribund Sacrifice |
Endocrine System |
Adrenal Cortex |
|
500 MG/KG |
10 |
56 |
56 |
59 |
1 |
Degeneration |
Mild, Fatty |
Moribund Sacrifice |
Endocrine System |
Adrenal Cortex |
|
500 MG/KG |
10 |
52 |
52 |
26 |
1 |
Degeneration |
Minimal, Fatty |
Natural Death |
Endocrine System |
Adrenal Cortex |
|
500 MG/KG |
10 |
58 |
58 |
33 |
1 |
Degeneration |
Minimal, Fatty |
Natural Death |
Endocrine System |
Parathyroid Gland |
|
500 MG/KG |
10 |
55 |
55 |
66 |
1 |
Cyst |
|
Moribund Sacrifice |
Genital System |
Epididymis |
Lumen |
500 MG/KG |
10 |
54 |
54 |
79 |
1 |
Cellular Alteration |
Mild |
Moribund Sacrifice |
Genital System |
Testes |
|
5 MG/KG |
10 |
23 |
23 |
93 |
1 |
Abnormal Residual Body |
Mild |
Terminal Sacrifice |
Genital System |
Testes |
|
100 MG/KG |
10 |
45 |
45 |
93 |
1 |
Abnormal Residual Body |
Mild |
Terminal Sacrifice |
Genital System |
Testes |
|
500 MG/KG |
10 |
54 |
54 |
79 |
1 |
Abnormal Residual Body |
Mild |
Moribund Sacrifice |
Genital System |
Testes |
|
500 MG/KG |
10 |
60 |
60 |
34 |
1 |
Abnormal Residual Body |
Mild |
Natural Death |
Genital System |
Testes |
|
500 MG/KG |
10 |
53 |
53 |
93 |
1 |
Abnormal Residual Body |
Mild |
Terminal Sacrifice |
Genital System |
Testes |
|
500 MG/KG |
10 |
57 |
57 |
93 |
1 |
Abnormal Residual Body |
Mild |
Terminal Sacrifice |
Genital System |
Testes |
|
500 MG/KG |
10 |
59 |
59 |
93 |
1 |
Abnormal Residual Body |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
Lymph Follic |
0.01 MG/KG |
10 |
20 |
20 |
93 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
Lymph Follic |
5 MG/KG |
10 |
29 |
29 |
93 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Spleen |
Lymph Follic |
500 MG/KG |
10 |
56 |
56 |
59 |
1 |
Atrophy |
Mild |
Moribund Sacrifice |
Hematopoietic System |
Spleen |
Lymph Follic |
500 MG/KG |
10 |
52 |
52 |
26 |
1 |
Atrophy |
Mild |
Natural Death |
Hematopoietic System |
Spleen |
Lymph Follic |
500 MG/KG |
10 |
58 |
58 |
33 |
1 |
Atrophy |
Mild |
Natural Death |
Hematopoietic System |
Thymus |
|
500 MG/KG |
9 |
55 |
55 |
66 |
1 |
Atrophy |
Minimal |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
500 MG/KG |
9 |
56 |
56 |
59 |
1 |
Atrophy |
Moderate |
Moribund Sacrifice |
Hematopoietic System |
Thymus |
|
500 MG/KG |
9 |
51 |
51 |
27 |
1 |
Atrophy |
Mild |
Natural Death |
Hematopoietic System |
Thymus |
|
500 MG/KG |
9 |
52 |
52 |
26 |
1 |
Atrophy |
Moderate |
Natural Death |
Hematopoietic System |
Thymus |
|
500 MG/KG |
9 |
58 |
58 |
33 |
1 |
Atrophy |
Moderate |
Natural Death |
Hematopoietic System |
Thymus |
|
500 MG/KG |
9 |
60 |
60 |
34 |
1 |
Atrophy |
Moderate |
Natural Death |
Hematopoietic System |
Thymus |
|
100 MG/KG |
10 |
49 |
49 |
93 |
1 |
Cyst |
|
Terminal Sacrifice |
Nervous System |
Brain |
|
100 MG/KG |
10 |
41 |
41 |
93 |
1 |
Cyst Epithelial Inclusion |
|
Terminal Sacrifice |
Nervous System |
Brain |
|
500 MG/KG |
10 |
55 |
55 |
66 |
1 |
Cyst Epithelial Inclusion |
|
Moribund Sacrifice |
Respiratory System |
Lung |
Alveolus |
0.01 MG/KG |
10 |
12 |
12 |
93 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Respiratory System |
Lung |
|
500 MG/KG |
10 |
58 |
58 |
33 |
1 |
Foreign Body |
|
Natural Death |
Respiratory System |
Lung |
|
0.01 MG/KG |
10 |
19 |
19 |
93 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Lung |
|
5 MG/KG |
10 |
24 |
24 |
93 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |
Respiratory System |
Lung |
|
500 MG/KG |
10 |
59 |
59 |
93 |
1 |
Inflammation |
Minimal |
Terminal Sacrifice |