Defined Category Analyses Deduplicate Gene Sets: false Data Source: IPP mg_kg Work Source: IPP mg_kg_williams_0.05_NOMTC_foldfilter1.5_BMD BMDExpress2 Version: BMDExpress 2.20.0151 BETA Timestamp (Start Time): 05/02/2018 07:58.45 Remove Promiscuous Probes: true Remove BMD > Highest Dose from Category Descriptive Statistics: true Remove BMD with p-Value < Cutoff: 0.1 Remove genes with BMDU/BMDL >: 40.0 Identify conflicting probe sets: 0.5 Probe File: S:\BMDExpress Data\Aromatic Phosphate w repeated samples\04122018 Analysis\Individual Gene Defined Category Files for Gene Level BMD Analysis of Array Platform GPL1355\Probe File_Rat230_2_ProbeSetID_EntrezGeneID_Match.txt Category File: S:\BMDExpress Data\Aromatic Phosphate w repeated samples\04122018 Analysis\Individual Gene Defined Category Files for Gene Level BMD Analysis of Array Platform GPL1355\Category_File_Rat_Individual_Gene_Category_File.txt Category Count: 645 Total Run Time: 6 seconds GO/Pathway/Gene Set ID GO/Pathway/Gene Set Name All Genes (Expression Data) All Genes (Platform) Input Genes Genes with BMD <= Highest Dose Genes with BMD p-Value >= Genes with BMDU/BMDL <= Genes That Passed All Filters Fisher's Exact Left P-Value Fisher's Exact Right P-Value Fisher's Exact Two Tail Percentage Entrez Gene IDs Gene Symbols Probe IDs Genes with Conflicting Probesets BMD Mean BMD Median BMD Minimum BMD Standard Deviation BMD wMean BMD wSD BMDL Mean BMDL Median BMDL Minimum BMDL Standard Deviation BMDL wMean BMDL wSD BMDU Mean BMDU Median BMDU Minimum BMDU Standard Deviation BMDU wMean BMDU wSD 5th Percentile Index BMD at 5th Percentile of Total Genes 10th Percentile Index BMD at 10th Percentile of Total Genes BMD List BMDL List BMDU List Probes with Adverse Direction Up Probes with Adverse Direction Down Genes with Adverse Direction Up Genes Up List Genes Up Probes List Genes Up BMD Mean Genes Up BMD Median Genes Up SD Genes Up BMDL Mean Genes Up BMDL Median Genes Up BMDL SD Genes Up BMDU Mean Genes Up BMDU Median Genes Up BMDU SD BMD list (up) BMDL List (up) BMDU List (up) Genes with Adverse Direction Down Genes Down List Genes Down Probes List Genes Down BMD Mean Genes Down BMD Median Genes Down SD Genes Down BMDL Mean Genes Down BMDL Median Genes Down BMDL SD Genes Down BMDU Mean Genes Down BMDU Median Genes Down BMDU SD BMD list (down) BMDL List (down) BMDU List (down) Genes with Adverse Conflict Count Genes Conflict List Genes Conflict Probes List BMD list (Conflict) BMDL list (Conflict) BMDU list (Conflict) Model Counts Mean Fold Change Total Fold Change Min Fold Change Max Fold Change Standard Deviation Fold Change Median Fold Change Lower bound of the 95% confidence interval - BMD Upper bound of the 95% confidence interval - BMD Lower bound of the 95% confidence interval - BMDL Upper bound of the 95% confidence interval - BMDL Lower bound of the 95% confidence interval - BMDU Upper bound of the 95% confidence interval - BMDU Overall Direction Percent Genes With Overall Direction Up Percent Genes With Overall Direction Down Percent Genes With Overall Direction Conflict Category 36 Aldh1a1 1 1 1 1 1 1 1 1.0 0.042769 0.042769 100.0 24188 1387022_at 23.4691 23.4691 23.4691 23.4691 10.3468 10.3468 10.3468 10.3468 61.8804 61.8804 61.8804 61.880399999999995 0.0 23.4691 0.0 23.4691 23.4691 10.3468 61.8804 1 0 1 24188 1387022_at 23.4691 23.4691 10.3468 10.3468 61.8804 61.8804 23.4691 10.3468 61.8804 0 0 Hill,1(1) 2.3373465538024902 2.3373465538024902 2.3373465538024902 2.3373465538024902 0.0 2.3373465538024902 NaN NaN NaN NaN NaN NaN UP 1.0 0.0 0.0 Category 78 Cbs 1 1 1 1 1 1 1 1.0 0.042769 0.042769 100.0 24250 1387178_a_at 43.6974 43.6974 43.6974 43.697399999999995 19.7927 19.7927 19.7927 19.7927 122.115 122.115 122.115 122.115 0.0 43.6974 0.0 43.6974 43.6974 19.7927 122.115 0 1 0 1 24250 1387178_a_at 43.6974 43.6974 19.7927 19.7927 122.115 122.115 43.6974 19.7927 122.115 0 Exp 4,1(1) 1.649901270866394 1.649901270866394 1.649901270866394 1.649901270866394 0.0 1.649901270866394 NaN NaN NaN NaN NaN NaN DOWN 0.0 1.0 0.0 Category 105 Cyp1a1 1 1 1 1 1 1 1 1.0 0.042769 0.042769 100.0 24296 1370269_at 223.304 223.304 223.304 223.30399999999997 155.45 155.45 155.45 155.45 405.808 405.808 405.808 405.80800000000005 0.0 223.304 0.0 223.304 223.304 155.45 405.808 1 0 1 24296 1370269_at 223.304 223.304 155.45 155.45 405.808 405.808 223.304 155.45 405.808 0 0 Exp 2,1(1) 2.6619012355804443 2.6619012355804443 2.6619012355804443 2.6619012355804443 0.0 2.6619012355804443 NaN NaN NaN NaN NaN NaN UP 1.0 0.0 0.0 Category 113 Dbp 1 1 1 1 1 1 1 1.0 0.042769 0.042769 100.0 24309 1387874_at 11.8966 11.8966 11.8966 11.8966 8.10261 8.10261 8.10261 8.10261 19.7027 19.7027 19.7027 19.7027 0.0 11.8966 0.0 11.8966 11.8966 8.10261 19.7027 1 0 1 24309 1387874_at 11.8966 11.8966 8.10261 8.10261 19.7027 19.7027 11.8966 8.10261 19.7027 0 0 Exp 4,1(1) 18.413969039916992 18.413969039916992 18.413969039916992 18.413969039916992 0.0 18.413969039916992 NaN NaN NaN NaN NaN NaN UP 1.0 0.0 0.0 Category 115 Ddc 1 1 1 1 1 1 1 1.0 0.042769 0.042769 100.0 24311 1368064_a_at 24311(0.2421) 69.1966 69.1966 69.1966 69.1966 44.3457 44.3457 44.3457 44.3457 151.833 151.833 151.833 151.833 0.0 69.1966 0.0 69.1966 69.1966 44.3457 151.833 1 0 1 24311 1368064_a_at 69.1966 69.1966 44.3457 44.3457 151.833 151.833 69.1966 44.3457 151.833 0 0 Poly 2,1(1) 1.643884301185608 1.643884301185608 1.643884301185608 1.643884301185608 0.0 1.643884301185608 NaN NaN NaN NaN NaN NaN UP 1.0 0.0 0.0 Category 117 Nqo1 1 1 1 1 1 1 1 1.0 0.042769 0.042769 100.0 24314 1387599_a_at 238.721 238.721 238.721 238.721 156.296 156.296 156.296 156.29600000000002 500.172 500.172 500.172 500.172 0.0 238.721 0.0 238.721 238.721 156.296 500.172 1 0 1 24314 1387599_a_at 238.721 238.721 156.296 156.296 500.172 500.172 238.721 156.296 500.172 0 0 Power,1(1) 2.0368752479553223 2.0368752479553223 2.0368752479553223 2.0368752479553223 0.0 2.0368752479553223 NaN NaN NaN NaN NaN NaN UP 1.0 0.0 0.0 Category 125 Egr1 1 1 1 1 1 0 0 0.95723 1.0 1.0 0.0 0 0 0 0 0 Category 126 Cela1 1 1 1 1 1 1 1 1.0 0.042769 0.042769 100.0 24331 1387819_at 27.7679 27.7679 27.7679 27.7679 5.8495 5.8495 5.8495 5.849499999999999 96.8218 96.8218 96.8218 96.8218 0.0 27.7679 0.0 27.7679 27.7679 5.8495 96.8218 0 1 0 1 24331 1387819_at 27.7679 27.7679 5.8495 5.8495 96.8218 96.8218 27.7679 5.8495 96.8218 0 Hill,1(1) 1.7382792234420776 1.7382792234420776 1.7382792234420776 1.7382792234420776 0.0 1.7382792234420776 NaN NaN NaN NaN NaN NaN DOWN 0.0 1.0 0.0 Category 151 Gck 1 1 1 1 1 1 1 1.0 0.042769 0.042769 100.0 24385 1387312_a_at 3.39134E-13 3.39134E-13 3.39134E-13 3.39134E-13 3.39134E-13 3.39134E-13 3.39134E-13 3.39134E-13 3.39135E-13 3.39135E-13 3.39135E-13 3.3913500000000005E-13 0.0 3.39134E-13 0.0 3.39134E-13 3.39134E-13 3.39134E-13 3.39135E-13 0 1 0 1 24385 1387312_a_at 3.39134E-13 3.39134E-13 3.39134E-13 3.39134E-13 3.39135E-13 3.39135E-13 3.39134E-13 3.39134E-13 3.39135E-13 0 Hill,1(1) 6.0660367012023935 6.066036701202393 6.066036701202393 6.066036701202393 0.0 6.066036701202393 NaN NaN NaN NaN NaN NaN DOWN 0.0 1.0 0.0 Category 179 Gsta2 1 1 1 1 1 1 1 1.0 0.042769 0.042769 100.0 24422 1368180_s_at 23.8335 23.8335 23.8335 23.8335 10.03 10.03 10.03 10.03 67.6576 67.6576 67.6576 67.6576 0.0 23.8335 0.0 23.8335 23.8335 10.03 67.6576 1 0 1 24422 1368180_s_at 23.8335 23.8335 10.03 10.03 67.6576 67.6576 23.8335 10.03 67.6576 0 0 Hill,1(1) 1.8944933414459229 1.8944933414459229 1.8944933414459229 1.8944933414459229 0.0 1.8944933414459229 NaN NaN NaN NaN NaN NaN UP 1.0 0.0 0.0 Category 182 Gstp1 1 1 1 1 1 1 1 1.0 0.042769 0.042769 100.0 24426 1388122_at 251.347 251.347 251.347 251.34699999999998 162.484 162.484 162.484 162.484 596.79 596.79 596.79 596.79 0.0 251.347 0.0 251.347 251.347 162.484 596.79 1 0 1 24426 1388122_at 251.347 251.347 162.484 162.484 596.79 596.79 251.347 162.484 596.79 0 0 Power,1(1) 1.6438429355621338 1.6438429355621338 1.6438429355621338 1.6438429355621338 0.0 1.6438429355621338 NaN NaN NaN NaN NaN NaN UP 1.0 0.0 0.0 Category 187 Hbb 1 1 1 1 1 1 1 1.0 0.042769 0.042769 100.0 24440 1367553_x_at 425.379 425.379 425.379 425.37899999999996 233.601 233.601 233.601 233.601 574.462 574.462 574.462 574.462 0.0 425.379 0.0 425.379 425.379 233.601 574.462 0 1 0 1 24440 1367553_x_at 425.379 425.379 233.601 233.601 574.462 574.462 425.379 233.601 574.462 0 Power,1(1) 3.0856900215148926 3.0856900215148926 3.0856900215148926 3.0856900215148926 0.0 3.0856900215148926 NaN NaN NaN NaN NaN NaN DOWN 0.0 1.0 0.0 Category 203 Hspa1a 1 1 1 1 1 1 1 1.0 0.042769 0.042769 100.0 24472 1368247_at 102.437 102.437 102.437 102.437 58.3999 58.3999 58.3999 58.3999 339.783 339.783 339.783 339.783 0.0 102.437 0.0 102.437 102.437 58.3999 339.783 0 1 0 1 24472 1368247_at 102.437 102.437 58.3999 58.3999 339.783 339.783 102.437 58.3999 339.783 0 Poly 2,1(1) 1.6570297479629517 1.6570297479629517 1.6570297479629517 1.6570297479629517 0.0 1.6570297479629517 NaN NaN NaN NaN NaN NaN DOWN 0.0 1.0 0.0 Category 209 Igf1 1 1 1 1 1 1 1 1.0 0.042769 0.042769 100.0 24482 1382599_at 24482(0.3136) 206.061 206.061 206.061 206.061 137.727 137.727 137.727 137.727 396.735 396.735 396.735 396.735 0.0 206.061 0.0 206.061 206.061 137.727 396.735 0 1 0 1 24482 1382599_at 206.061 206.061 137.727 137.727 396.735 396.735 206.061 137.727 396.735 0 Exp 2,1(1) 1.6018880605697632 1.6018880605697632 1.6018880605697632 1.6018880605697632 0.0 1.6018880605697632 NaN NaN NaN NaN NaN NaN DOWN 0.0 1.0 0.0 Category 211 Igfbp3 1 1 1 1 1 1 1 1.0 0.042769 0.042769 100.0 24484 1367652_at,1386881_at 210.0905 210.0905 210.0905 210.0905 143.6565 143.6565 143.6565 143.6565 280.80150000000003 280.80150000000003 280.80150000000003 280.80150000000003 0.0 210.0905 0.0 210.0905 210.0905 143.6565 280.80150000000003 0 2 0 1 24484 1367652_at,1386881_at 210.0905 210.0905 143.6565 143.6565 280.80150000000003 280.80150000000003 210.0905 143.6565 280.80150000000003 0 Hill,2(1) 1.8107841416370256 3.625913381576538 1.7242281436920166 1.9016852378845215 0.1254811146731801 1.812956690788269 0.002494191493655068 0.002594302960553121 1.3880105521152319E-13 1.9858480755760508E-13 2.4151028719776922E-29 3.69746702691652E-29 DOWN 0.0 1.0 0.0 Category 224 Irf1 1 1 1 1 1 1 1 1.0 0.042769 0.042769 100.0 24508 1368073_at 37.9818 37.9818 37.9818 37.9818 27.1461 27.1461 27.1461 27.146099999999997 61.5232 61.5232 61.5232 61.52320000000001 0.0 37.9818 0.0 37.9818 37.9818 27.1461 61.5232 0 1 0 1 24508 1368073_at 37.9818 37.9818 27.1461 27.1461 61.5232 61.5232 37.9818 27.1461 61.5232 0 Poly 2,1(1) 2.2532479763031006 2.2532479763031006 2.2532479763031006 2.2532479763031006 0.0 2.2532479763031006 NaN NaN NaN NaN NaN NaN DOWN 0.0 1.0 0.0 Category 229 Junb 1 1 1 1 1 1 1 1.0 0.042769 0.042769 100.0 24517 1387788_at 72.6042 72.6042 72.6042 72.6042 39.3669 39.3669 39.3669 39.3669 83.0136 83.0136 83.0136 83.0136 0.0 72.6042 0.0 72.6042 72.6042 39.3669 83.0136 0 1 0 1 24517 1387788_at 72.6042 72.6042 39.3669 39.3669 83.0136 83.0136 72.6042 39.3669 83.0136 0 Hill,1(1) 2.1577696800231934 2.1577696800231934 2.1577696800231934 2.1577696800231934 0.0 2.1577696800231934 NaN NaN NaN NaN NaN NaN DOWN 0.0 1.0 0.0 Category 242 Lpl 1 1 1 1 1 1 1 1.0 0.042769 0.042769 100.0 24539 1386965_at 42.7776 42.7776 42.7776 42.7776 30.1149 30.1149 30.1149 30.1149 71.8337 71.8337 71.8337 71.8337 0.0 42.7776 0.0 42.7776 42.7776 30.1149 71.8337 0 1 0 1 24539 1386965_at 42.7776 42.7776 30.1149 30.1149 71.8337 71.8337 42.7776 30.1149 71.8337 0 Poly 2,1(1) 2.4388160705566406 2.4388160705566406 2.4388160705566406 2.4388160705566406 0.0 2.4388160705566406 NaN NaN NaN NaN NaN NaN DOWN 0.0 1.0 0.0 Category 247 Me1 1 1 1 1 1 1 1 1.0 0.042769 0.042769 100.0 24552 1370067_at 290.612 290.612 290.612 290.612 180.572 180.572 180.572 180.572 733.264 733.264 733.264 733.264 0.0 290.612 0.0 290.612 290.612 180.572 733.264 1 0 1 24552 1370067_at 290.612 290.612 180.572 180.572 733.264 733.264 290.612 180.572 733.264 0 0 Linear,1(1) 1.543191909790039 1.543191909790039 1.543191909790039 1.543191909790039 0.0 1.543191909790039 NaN NaN NaN NaN NaN NaN UP 1.0 0.0 0.0 Category 259 Mx1 1 1 1 1 0 1 0 0.95723 1.0 1.0 0.0 0 0 0 0 0 Category 269 Mme 1 1 1 1 1 0 0 0.95723 1.0 1.0 0.0 0 0 0 0 0 Category 296 Pdgfrb 1 1 1 1 1 1 1 1.0 0.042769 0.042769 100.0 24629 1370642_s_at 24629(-0.1598) 30.8138 30.8138 30.8138 30.8138 16.3782 16.3782 16.3782 16.3782 70.3004 70.3004 70.3004 70.3004 0.0 30.8138 0.0 30.8138 30.8138 16.3782 70.3004 0 1 0 1 24629 1370642_s_at 30.8138 30.8138 16.3782 16.3782 70.3004 70.3004 30.8138 16.3782 70.3004 0 Exp 4,1(1) 1.7460671663284302 1.7460671663284302 1.7460671663284302 1.7460671663284302 0.0 1.7460671663284302 NaN NaN NaN NaN NaN NaN DOWN 0.0 1.0 0.0 Category 304 Abcb1b 1 1 1 1 1 1 1 1.0 0.042769 0.042769 100.0 24646 1370583_s_at 197.653 197.653 197.653 197.65299999999996 138.459 138.459 138.459 138.459 345.621 345.621 345.621 345.621 0.0 197.653 0.0 197.653 197.653 138.459 345.621 1 0 1 24646 1370583_s_at 197.653 197.653 138.459 138.459 345.621 345.621 197.653 138.459 345.621 0 0 Exp 2,1(1) 1.8305906057357788 1.8305906057357788 1.8305906057357788 1.8305906057357788 0.0 1.8305906057357788 NaN NaN NaN NaN NaN NaN UP 1.0 0.0 0.0 Category 324 Ppp3ca 1 1 1 1 1 1 1 1.0 0.042769 0.042769 100.0 24674 1373479_at 24674(-0.6341) 21.5237 21.5237 21.5237 21.5237 5.95061 5.95061 5.95061 5.95061 65.0759 65.0759 65.0759 65.0759 0.0 21.5237 0.0 21.5237 21.5237 5.95061 65.0759 1 0 1 24674 1373479_at 21.5237 21.5237 5.95061 5.95061 65.0759 65.0759 21.5237 5.95061 65.0759 0 0 Hill,1(1) 1.6709486246109009 1.6709486246109009 1.6709486246109009 1.6709486246109009 0.0 1.6709486246109009 NaN NaN NaN NaN NaN NaN UP 1.0 0.0 0.0 Category 349 Rbp2 1 1 1 1 0 0 0 0.95723 1.0 1.0 0.0 0 0 0 0 0 Category 369 Sdc4 1 1 1 1 1 1 1 1.0 0.042769 0.042769 100.0 24771 1367721_at 22.023 22.023 22.023 22.023 9.26277 9.26277 9.26277 9.26277 52.3889 52.3889 52.3889 52.3889 0.0 22.023 0.0 22.023 22.023 9.26277 52.3889 0 1 0 1 24771 1367721_at 22.023 22.023 9.26277 9.26277 52.3889 52.3889 22.023 9.26277 52.3889 0 Exp 4,1(1) 2.0138542652130127 2.0138542652130127 2.0138542652130127 2.0138542652130127 0.0 2.0138542652130127 NaN NaN NaN NaN NaN NaN DOWN 0.0 1.0 0.0 Category 370 Cxcl12 1 1 1 1 1 1 1 1.0 0.042769 0.042769 100.0 24772 1369633_at 24772(0.486) 82.7397 82.7397 82.7397 82.7397 26.2288 26.2288 26.2288 26.2288 363.056 363.056 363.056 363.056 0.0 82.7397 0.0 82.7397 82.7397 26.2288 363.056 1 0 1 24772 1369633_at 82.7397 82.7397 26.2288 26.2288 363.056 363.056 82.7397 26.2288 363.056 0 0 Exp 4,1(1) 1.5639930963516235 1.5639930963516235 1.5639930963516235 1.5639930963516235 0.0 1.5639930963516235 NaN NaN NaN NaN NaN NaN UP 1.0 0.0 0.0 Category 409 Tf 1 1 1 1 1 1 1 1.0 0.042769 0.042769 100.0 24825 1391323_at 109.38 109.38 109.38 109.38000000000001 76.2941 76.2941 76.2941 76.2941 176.032 176.032 176.032 176.032 0.0 109.38 0.0 109.38 109.38 76.2941 176.032 1 0 1 24825 1391323_at 109.38 109.38 76.2941 76.2941 176.032 176.032 109.38 76.2941 176.032 0 0 Hill,1(1) 1.7038202285766602 1.7038202285766602 1.7038202285766602 1.7038202285766602 0.0 1.7038202285766602 NaN NaN NaN NaN NaN NaN UP 1.0 0.0 0.0 Category 416 Spink3 1 1 1 1 1 0 0 0.95723 1.0 1.0 0.0 0 0 0 0 0 Category 417 Tk1 1 1 1 1 1 1 1 1.0 0.042769 0.042769 100.0 24834 1389858_at 24834(0.3424) 252.04 252.04 252.04 252.04000000000002 136.261 136.261 136.261 136.261 441.603 441.603 441.603 441.603 0.0 252.04 0.0 252.04 252.04 136.261 441.603 1 0 1 24834 1389858_at 252.04 252.04 136.261 136.261 441.603 441.603 252.04 136.261 441.603 0 0 Exp 3,1(1) 1.9516631364822388 1.9516631364822388 1.9516631364822388 1.9516631364822388 0.0 1.9516631364822388 NaN NaN NaN NaN NaN NaN UP 1.0 0.0 0.0 Category 428 Tpm4 1 1 1 1 1 1 1 1.0 0.042769 0.042769 100.0 24852 1371653_at 37.7629 37.7629 37.7629 37.7629 27.0595 27.0595 27.0595 27.0595 60.6879 60.6879 60.6879 60.6879 0.0 37.7629 0.0 37.7629 37.7629 27.0595 60.6879 0 1 0 1 24852 1371653_at 37.7629 37.7629 27.0595 27.0595 60.6879 60.6879 37.7629 27.0595 60.6879 0 Poly 2,1(1) 1.6312376260757446 1.6312376260757446 1.6312376260757446 1.6312376260757446 0.0 1.6312376260757446 NaN NaN NaN NaN NaN NaN DOWN 0.0 1.0 0.0 Category 439 Vipr1 1 1 1 1 1 1 1 1.0 0.042769 0.042769 100.0 24875 1383695_at 24875(0.3085) 170.256 170.256 170.256 170.256 50.2817 50.2817 50.2817 50.2817 303.452 303.452 303.452 303.452 0.0 170.256 0.0 170.256 170.256 50.2817 303.452 0 1 0 1 24875 1383695_at 170.256 170.256 50.2817 50.2817 303.452 303.452 170.256 50.2817 303.452 0 Hill,1(1) 1.5456511974334717 1.5456511974334717 1.5456511974334717 1.5456511974334717 0.0 1.5456511974334717 NaN NaN NaN NaN NaN NaN DOWN 0.0 1.0 0.0 Category 444 Yes1 1 1 1 1 1 1 1 1.0 0.042769 0.042769 100.0 24884 1374751_at 579.348 579.348 579.348 579.348 217.096 217.096 217.096 217.096 601.196 601.196 601.196 601.196 0.0 579.348 0.0 579.348 579.348 217.096 601.196 1 0 1 24884 1374751_at 579.348 579.348 217.096 217.096 601.196 601.196 579.348 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