Gene Ontology Analyses GO Category: BP GO File Creation Date: 07/15/20 Deduplicate Gene Sets: true Data Source: Kidney_10-2 FTOH_Male Work Source: Kidney_10-2 FTOH_Male_williams_0.05_NOMTC_foldfilter1.5_BMD BMDExpress2 Version: BMDExpress 2.30.0507 BETA Timestamp (Start Time): 02/12/2021 22:59.28 Remove Promiscuous Probes: true Remove BMD > Highest Dose from Category Descriptive Statistics: true Remove BMD with p-Value < Cutoff: 0.1 Remove genes with BMDU/BMDL >: 40.0 Identify conflicting probe sets: 0.5 Category Count: 2858 Total Run Time: 0 seconds GO/Pathway/Gene Set/Gene ID GO Level GO/Pathway/Gene Set/Gene Name All Genes (Expression Data) All Genes (Platform) Input Genes Genes with BMD <= Highest Dose Genes with BMD p-Value >= Genes with BMDU/BMDL <= Genes That Passed All Filters Fisher's A Parameter Fisher's B Parameter Fisher's C Parameter Fisher's D Parameter Fisher's Exact Left P-Value Fisher's Exact Right P-Value Fisher's Exact Two Tail Percentage Entrez Gene IDs Gene Symbols Probe IDs Genes with Conflicting Probesets BMD Mean BMD Median BMD Minimum BMD Standard Deviation BMD wMean BMD wSD BMDL Mean BMDL Median BMDL Minimum BMDL Standard Deviation BMDL wMean BMDL wSD BMDU Mean BMDU Median BMDU Minimum BMDU Standard Deviation BMDU wMean BMDU wSD 5th Percentile Index BMD at 5th Percentile of Total Genes 10th Percentile Index BMD at 10th Percentile of Total Genes BMD List BMDL List BMDU List Probes with Adverse Direction Up Probes with Adverse Direction Down Genes with Adverse Direction Up Genes Up List Genes Up Probes List Genes Up BMD Mean Genes Up BMD Median Genes Up SD Genes Up BMDL Mean Genes Up BMDL Median Genes Up BMDL SD Genes Up BMDU Mean Genes Up BMDU Median Genes Up BMDU SD BMD list (up) BMDL List (up) BMDU List (up) Genes with Adverse Direction Down Genes Down List Genes Down Probes List Genes Down BMD Mean Genes Down BMD Median Genes Down SD Genes Down BMDL Mean Genes Down BMDL Median Genes Down BMDL SD Genes Down BMDU Mean Genes Down BMDU Median Genes Down BMDU SD BMD list (down) BMDL List (down) BMDU List (down) Genes with Adverse Conflict Count Genes Conflict List Genes Conflict Probes List BMD list (Conflict) BMDL list (Conflict) BMDU list (Conflict) Model Counts Mean Fold Change Total Fold Change Min Fold Change Max Fold Change Standard Deviation Fold Change Median Fold Change Lower bound of the 95% confidence interval - BMD Upper bound of the 95% confidence interval - BMD Lower bound of the 95% confidence interval - BMDL Upper bound of the 95% confidence interval - BMDL Lower bound of the 95% confidence interval - BMDU Upper bound of the 95% confidence interval - BMDU Overall Direction Percent Genes With Overall Direction Up Percent Genes With Overall Direction Down Percent Genes With Overall Direction Conflict GO:0000083 7 regulation of transcription involved in G1/S transition of mitotic cell cycle 3 3 1 1 1 0 0 0 59 3 2485 0.93208 1.0 1.0 0.0 0 0 0 0 0 GO:0000096 6 sulfur amino acid metabolic process 12 14 1 1 1 0 0 0 59 14 2474 0.71967 1.0 1.0 0.0 0 0 0 0 0 GO:0000132 8 establishment of mitotic spindle orientation 8 8 1 1 1 0 0 0 59 8 2480 0.82882 1.0 1.0 0.0 0 0 0 0 0 GO:0000209 10 protein polyubiquitination 28 29 1 1 0 1 0 0 59 29 2459 0.50486 1.0 1.0 0.0 0 0 0 0 0 GO:0000281 5 mitotic cytokinesis 13 16 1 1 0 1 0 0 59 16 2472 0.68652 1.0 1.0 0.0 0 0 0 0 0 GO:0000738 7 DNA catabolic process, exonucleolytic 2 2 1 1 1 0 0 0 59 2 2486 0.9542 1.0 1.0 0.0 0 0 0 0 0 GO:0000910 4 cytokinesis 16 19 1 1 0 1 0 0 59 19 2469 0.63961 1.0 1.0 0.0 0 0 0 0 0 GO:0001503 3 ossification 29 30 2 2 2 0 0 0 59 30 2458 0.49303 1.0 1.0 0.0 0 0 0 0 0 GO:0001550 3 ovarian cumulus expansion 2 2 1 1 0 1 0 0 59 2 2486 0.9542 1.0 1.0 0.0 0 0 0 0 0 GO:0001776 5 leukocyte homeostasis 24 26 1 1 1 0 0 0 59 26 2462 0.54204 1.0 1.0 0.0 0 0 0 0 0 GO:0001836 8 release of cytochrome c from mitochondria 13 13 1 1 0 1 0 0 59 13 2475 0.73682 1.0 1.0 0.0 0 0 0 0 0 GO:0001894 6 tissue homeostasis 38 39 1 1 1 0 0 0 59 39 2449 0.39812 1.0 1.0 0.0 0 0 0 0 0 GO:0001937 8 negative regulation of endothelial cell proliferation 16 17 2 2 2 0 0 0 59 17 2471 0.67052 1.0 1.0 0.0 0 0 0 0 0 GO:0001977 6 renal system process involved in regulation of blood volume 4 5 1 1 1 0 0 0 59 5 2483 0.88934 1.0 1.0 0.0 0 0 0 0 0 GO:0002021 5 response to dietary excess 3 3 1 1 1 0 0 0 59 3 2485 0.93208 1.0 1.0 0.0 0 0 0 0 0 GO:0002040 5 sprouting angiogenesis 14 14 1 1 1 0 0 0 59 14 2474 0.71967 1.0 1.0 0.0 0 0 0 0 0 GO:0002070 5 epithelial cell maturation 7 8 1 1 1 0 0 0 59 8 2480 0.82882 1.0 1.0 0.0 0 0 0 0 0 GO:0002088 4 lens development in camera-type eye 8 8 1 1 1 0 0 0 59 8 2480 0.82882 1.0 1.0 0.0 0 0 0 0 0 GO:0002260 6 lymphocyte homeostasis 22 24 1 1 1 0 0 0 59 24 2464 0.56832 1.0 1.0 0.0 0 0 0 0 0 GO:0002521 5 leukocyte differentiation 80 87 2 2 1 1 0 0 59 87 2401 0.1256 1.0 0.2659 0.0 0 0 0 0 0 GO:0002573 6 myeloid leukocyte differentiation 36 39 1 1 0 1 0 0 59 39 2449 0.39812 1.0 1.0 0.0 0 0 0 0 0 GO:0002691 6 regulation of cellular extravasation 15 15 1 1 1 0 0 0 59 15 2473 0.7029 1.0 1.0 0.0 0 0 0 0 0 GO:0002763 8 positive regulation of myeloid leukocyte differentiation 25 28 1 1 0 1 0 0 59 28 2460 0.51696 1.0 1.0 0.0 0 0 0 0 0 GO:0002931 4 response to ischemia 27 28 1 1 1 0 0 0 59 28 2460 0.51696 1.0 1.0 0.0 0 0 0 0 0 GO:0003013 4 circulatory system process 81 84 3 3 3 0 0 0 59 84 2404 0.13508 1.0 0.26292 0.0 0 0 0 0 0 GO:0003014 4 renal system process 24 25 1 1 1 0 0 0 59 25 2463 0.55503 1.0 1.0 0.0 0 0 0 0 0 GO:0003015 5 heart process 9 10 1 1 1 0 0 0 59 10 2478 0.79074 1.0 1.0 0.0 0 0 0 0 0 GO:0003018 5 vascular process in circulatory system 70 73 2 2 2 0 0 0 59 73 2415 0.17625 1.0 0.41437 0.0 0 0 0 0 0 GO:0003071 5 renal system process involved in regulation of systemic arterial blood pressure 6 7 1 1 1 0 0 0 59 7 2481 0.84853 1.0 1.0 0.0 0 0 0 0 0 GO:0003093 7 regulation of glomerular filtration 3 3 1 1 1 0 0 0 59 3 2485 0.93208 1.0 1.0 0.0 0 0 0 0 0 GO:0003104 7 positive regulation of glomerular filtration 2 2 1 1 1 0 0 0 59 2 2486 0.9542 1.0 1.0 0.0 0 0 0 0 0 GO:0003151 4 outflow tract morphogenesis 14 16 1 1 0 1 0 0 59 16 2472 0.68652 1.0 1.0 0.0 0 0 0 0 0 GO:0003158 6 endothelium development 5 5 1 1 1 0 0 0 59 5 2483 0.88934 1.0 1.0 0.0 0 0 0 0 0 GO:0003254 5 regulation of membrane depolarization 11 11 1 1 1 0 0 0 59 11 2477 0.77235 1.0 1.0 0.0 0 0 0 0 0 GO:0003294 4 atrial ventricular junction remodeling 1 1 1 1 1 0 0 0 59 1 2487 0.97684 1.0 1.0 0.0 0 0 0 0 0 GO:0006109 6 regulation of carbohydrate metabolic process 61 66 1 1 1 0 0 0 59 66 2422 0.20864 1.0 0.40396 0.0 0 0 0 0 0 GO:0006110 6 regulation of glycolytic process 22 23 1 1 1 0 0 0 59 23 2465 0.58192 1.0 1.0 0.0 0 0 0 0 0 GO:0006140 6 regulation of nucleotide metabolic process 30 33 1 1 1 0 0 0 59 33 2455 0.45915 1.0 1.0 0.0 0 0 0 0 0 GO:0006308 6 DNA catabolic process 5 5 1 1 1 0 0 0 59 5 2483 0.88934 1.0 1.0 0.0 0 0 0 0 0 GO:0006325 5 chromatin organization 88 101 1 1 0 0 0 0 59 101 2387 0.089327 1.0 0.17135 0.0 0 0 0 0 0 GO:0006334 7 nucleosome assembly 12 19 1 1 0 0 0 0 59 19 2469 0.63961 1.0 1.0 0.0 0 0 0 0 0 GO:0006338 6 chromatin remodeling 22 24 1 1 0 0 0 0 59 24 2464 0.56832 1.0 1.0 0.0 0 0 0 0 0 GO:0006417 7 regulation of translation 60 67 1 1 0 1 0 0 59 67 2421 0.20367 1.0 0.40499 0.0 0 0 0 0 0 GO:0006486 6 protein glycosylation 32 33 1 1 0 0 0 0 59 33 2455 0.45915 1.0 1.0 0.0 0 0 0 0 0 GO:0006493 7 protein O-linked glycosylation 12 13 1 1 0 0 0 0 59 13 2475 0.73682 1.0 1.0 0.0 0 0 0 0 0 GO:0006513 10 protein monoubiquitination 10 10 1 1 0 1 0 0 59 10 2478 0.79074 1.0 1.0 0.0 0 0 0 0 0 GO:0006707 6 cholesterol catabolic process 4 4 1 1 1 0 0 0 59 4 2484 0.91046 1.0 1.0 0.0 0 0 0 0 0 GO:0006722 7 triterpenoid metabolic process 1 1 1 1 0 0 0 0 59 1 2487 0.97684 1.0 1.0 0.0 0 0 0 0 0 GO:0006797 5 polyphosphate metabolic process 1 1 1 1 1 0 0 0 59 1 2487 0.97684 1.0 1.0 0.0 0 0 0 0 0 GO:0006798 5 polyphosphate catabolic process 1 1 1 1 1 0 0 0 59 1 2487 0.97684 1.0 1.0 0.0 0 0 0 0 0 GO:0006801 5 superoxide metabolic process 12 13 2 2 2 0 0 0 59 13 2475 0.73682 1.0 1.0 0.0 0 0 0 0 0 GO:0006857 7 oligopeptide transport 5 5 1 1 1 0 0 0 59 5 2483 0.88934 1.0 1.0 0.0 0 0 0 0 0 GO:0006862 7 nucleotide transport 7 7 1 1 1 0 0 0 59 7 2481 0.84853 1.0 1.0 0.0 0 0 0 0 0 GO:0006897 5 endocytosis 72 75 2 2 1 1 0 0 59 75 2413 0.16794 1.0 0.41859 0.0 0 0 0 0 0 GO:0006898 6 receptor-mediated endocytosis 38 39 2 2 1 1 0 0 59 39 2449 0.39812 1.0 1.0 0.0 0 0 0 0 0 GO:0006997 6 nucleus organization 16 16 1 1 0 0 0 0 59 16 2472 0.68652 1.0 1.0 0.0 0 0 0 0 0 GO:0007005 6 mitochondrion organization 66 71 1 1 0 1 0 0 59 71 2417 0.18496 1.0 0.41066 0.0 0 0 0 0 0 GO:0007043 7 cell-cell junction assembly 20 20 1 1 1 0 0 0 59 20 2468 0.62468 1.0 1.0 0.0 0 0 0 0 0 GO:0007178 7 transmembrane receptor protein serine/threonine kinase signaling pathway 41 43 2 2 1 1 0 0 59 43 2445 0.36193 1.0 0.6246 0.0 0 0 0 0 0 GO:0007179 8 transforming growth factor beta receptor signaling pathway 27 29 2 2 1 1 0 0 59 29 2459 0.50486 1.0 1.0 0.0 0 0 0 0 0 GO:0007249 6 I-kappaB kinase/NF-kappaB signaling 15 16 1 1 1 0 0 0 59 16 2472 0.68652 1.0 1.0 0.0 0 0 0 0 0 GO:0007265 7 Ras protein signal transduction 42 44 1 1 0 1 0 0 59 44 2444 0.35341 1.0 0.62477 0.0 0 0 0 0 0 GO:0007289 5 spermatid nucleus differentiation 3 3 1 1 0 0 0 0 59 3 2485 0.93208 1.0 1.0 0.0 0 0 0 0 0 GO:0007512 6 adult heart development 6 7 1 1 1 0 0 0 59 7 2481 0.84853 1.0 1.0 0.0 0 0 0 0 0 GO:0007569 4 cell aging 31 33 1 1 1 0 0 0 59 33 2455 0.45915 1.0 1.0 0.0 0 0 0 0 0 GO:0007589 5 body fluid secretion 28 29 1 1 1 0 0 0 59 29 2459 0.50486 1.0 1.0 0.0 0 0 0 0 0 GO:0008406 5 gonad development 45 49 3 3 2 0 0 0 59 49 2439 0.31364 1.0 0.62839 0.0 0 0 0 0 0 GO:0008544 5 epidermis development 10 10 1 1 0 0 0 0 59 10 2478 0.79074 1.0 1.0 0.0 0 0 0 0 0 GO:0008584 6 male gonad development 41 45 3 3 2 0 0 0 59 45 2443 0.34508 1.0 0.62513 0.0 0 0 0 0 0 GO:0008637 7 apoptotic mitochondrial changes 27 27 1 1 0 1 0 0 59 27 2461 0.52936 1.0 1.0 0.0 0 0 0 0 0 GO:0008643 6 carbohydrate transport 15 17 1 1 0 1 0 0 59 17 2471 0.67052 1.0 1.0 0.0 0 0 0 0 0 GO:0010001 5 glial cell differentiation 30 32 1 1 1 0 0 0 59 32 2456 0.47018 1.0 1.0 0.0 0 0 0 0 0 GO:0010226 6 response to lithium ion 21 24 1 1 0 1 0 0 59 24 2464 0.56832 1.0 1.0 0.0 0 0 0 0 0 GO:0010232 5 vascular transport 6 6 1 1 1 0 0 0 59 6 2482 0.8687 1.0 1.0 0.0 0 0 0 0 0 GO:0010470 6 regulation of gastrulation 12 12 2 2 2 0 0 0 59 12 2476 0.75438 1.0 1.0 0.0 0 0 0 0 0 GO:0010543 6 regulation of platelet activation 17 18 1 1 1 0 0 0 59 18 2470 0.65488 1.0 1.0 0.0 0 0 0 0 0 GO:0010544 7 negative regulation of platelet activation 9 9 1 1 1 0 0 0 59 9 2479 0.80956 1.0 1.0 0.0 0 0 0 0 0 GO:0010596 7 negative regulation of endothelial cell migration 17 18 1 1 1 0 0 0 59 18 2470 0.65488 1.0 1.0 0.0 0 0 0 0 0 GO:0010633 6 negative regulation of epithelial cell migration 18 21 1 1 1 0 0 0 59 21 2467 0.61009 1.0 1.0 0.0 0 0 0 0 0 GO:0010643 4 cell communication by chemical coupling 1 1 1 1 1 0 0 0 59 1 2487 0.97684 1.0 1.0 0.0 0 0 0 0 0 GO:0010644 4 cell communication by electrical coupling 2 2 1 1 1 0 0 0 59 2 2486 0.9542 1.0 1.0 0.0 0 0 0 0 0 GO:0010645 6 regulation of cell communication by chemical coupling 1 1 1 1 1 0 0 0 59 1 2487 0.97684 1.0 1.0 0.0 0 0 0 0 0 GO:0010649 6 regulation of cell communication by electrical coupling 4 4 1 1 1 0 0 0 59 4 2484 0.91046 1.0 1.0 0.0 0 0 0 0 0 GO:0010652 7 positive regulation of cell communication by chemical coupling 1 1 1 1 1 0 0 0 59 1 2487 0.97684 1.0 1.0 0.0 0 0 0 0 0 GO:0010675 6 regulation of cellular carbohydrate metabolic process 47 50 1 1 1 0 0 0 59 50 2438 0.30623 1.0 0.62961 0.0 0 0 0 0 0 GO:0010677 7 negative regulation of cellular carbohydrate metabolic process 17 20 1 1 1 0 0 0 59 20 2468 0.62468 1.0 1.0 0.0 0 0 0 0 0 GO:0010770 8 positive regulation of cell morphogenesis involved in differentiation 40 44 1 1 1 0 0 0 59 44 2444 0.35341 1.0 0.62477 0.0 0 0 0 0 0 GO:0010799 9 regulation of peptidyl-threonine phosphorylation 13 15 1 1 1 0 0 0 59 15 2473 0.7029 1.0 1.0 0.0 0 0 0 0 0 GO:0010801 10 negative regulation of peptidyl-threonine phosphorylation 4 5 1 1 1 0 0 0 59 5 2483 0.88934 1.0 1.0 0.0 0 0 0 0 0 GO:0010872 6 regulation of cholesterol esterification 4 4 1 1 1 0 0 0 59 4 2484 0.91046 1.0 1.0 0.0 0 0 0 0 0 GO:0010873 7 positive regulation of cholesterol esterification 4 4 1 1 1 0 0 0 59 4 2484 0.91046 1.0 1.0 0.0 0 0 0 0 0 GO:0010874 9 regulation of cholesterol efflux 9 10 1 1 1 0 0 0 59 10 2478 0.79074 1.0 1.0 0.0 0 0 0 0 0 GO:0010875 9 positive regulation of cholesterol efflux 9 9 1 1 1 0 0 0 59 9 2479 0.80956 1.0 1.0 0.0 0 0 0 0 0 GO:0010877 7 lipid transport involved in lipid storage 1 1 1 1 1 0 0 0 59 1 2487 0.97684 1.0 1.0 0.0 0 0 0 0 0 GO:0010894 8 negative regulation of steroid biosynthetic process 5 5 1 1 1 0 0 0 59 5 2483 0.88934 1.0 1.0 0.0 0 0 0 0 0 GO:0010896 7 regulation of triglyceride catabolic process 9 11 1 1 1 0 0 0 59 11 2477 0.77235 1.0 1.0 0.0 0 0 0 0 0 GO:0010898 8 positive regulation of triglyceride catabolic process 5 7 1 1 1 0 0 0 59 7 2481 0.84853 1.0 1.0 0.0 0 0 0 0 0 GO:0010921 7 regulation of phosphatase activity 30 35 1 1 1 0 0 0 59 35 2453 0.43785 1.0 1.0 0.0 0 0 0 0 0 GO:0010922 8 positive regulation of phosphatase activity 12 14 1 1 1 0 0 0 59 14 2474 0.71967 1.0 1.0 0.0 0 0 0 0 0 GO:0010939 6 regulation of necrotic cell death 13 13 1 1 1 0 0 0 59 13 2475 0.73682 1.0 1.0 0.0 0 0 0 0 0 GO:0010940 7 positive regulation of necrotic cell death 3 3 1 1 1 0 0 0 59 3 2485 0.93208 1.0 1.0 0.0 0 0 0 0 0 GO:0010948 7 negative regulation of cell cycle process 56 60 1 1 1 0 0 0 59 60 2428 0.241 1.0 0.40147 0.0 0 0 0 0 0 GO:0014005 6 microglia development 3 3 1 1 1 0 0 0 59 3 2485 0.93208 1.0 1.0 0.0 0 0 0 0 0 GO:0014012 8 peripheral nervous system axon regeneration 7 7 1 1 1 0 0 0 59 7 2481 0.84853 1.0 1.0 0.0 0 0 0 0 0 GO:0014047 6 glutamate secretion 3 3 1 1 1 0 0 0 59 3 2485 0.93208 1.0 1.0 0.0 0 0 0 0 0 GO:0014066 7 regulation of phosphatidylinositol 3-kinase signaling 27 30 1 0 0 0 0 0 59 30 2458 0.49303 1.0 1.0 0.0 0 0 0 0 0 GO:0014068 8 positive regulation of phosphatidylinositol 3-kinase signaling 22 25 1 0 0 0 0 0 59 25 2463 0.55503 1.0 1.0 0.0 0 0 0 0 0 GO:0014910 7 regulation of smooth muscle cell migration 45 50 2 2 2 0 0 0 59 50 2438 0.30623 1.0 0.62961 0.0 0 0 0 0 0 GO:0014911 8 positive regulation of smooth muscle cell migration 32 35 2 2 2 0 0 0 59 35 2453 0.43785 1.0 1.0 0.0 0 0 0 0 0 GO:0015721 7 bile acid and bile salt transport 18 18 2 2 1 1 0 0 59 18 2470 0.65488 1.0 1.0 0.0 0 0 0 0 0 GO:0015722 7 canalicular bile acid transport 4 4 1 1 0 1 0 0 59 4 2484 0.91046 1.0 1.0 0.0 0 0 0 0 0 GO:0015748 6 organophosphate ester transport 28 28 2 2 2 0 0 0 59 28 2460 0.51696 1.0 1.0 0.0 0 0 0 0 0 GO:0015850 6 organic hydroxy compound transport 49 50 3 3 2 1 0 0 59 50 2438 0.30623 1.0 0.62961 0.0 0 0 0 0 0 GO:0015865 8 purine nucleotide transport 7 7 1 1 1 0 0 0 59 7 2481 0.84853 1.0 1.0 0.0 0 0 0 0 0 GO:0015867 6 ATP transport 5 5 1 1 1 0 0 0 59 5 2483 0.88934 1.0 1.0 0.0 0 0 0 0 0 GO:0015868 7 purine ribonucleotide transport 7 7 1 1 1 0 0 0 59 7 2481 0.84853 1.0 1.0 0.0 0 0 0 0 0 GO:0015909 8 long-chain fatty acid transport 19 21 1 1 1 0 0 0 59 21 2467 0.61009 1.0 1.0 0.0 0 0 0 0 0 GO:0015914 7 phospholipid transport 20 20 1 1 1 0 0 0 59 20 2468 0.62468 1.0 1.0 0.0 0 0 0 0 0 GO:0015918 7 sterol transport 19 19 1 1 1 0 0 0 59 19 2469 0.63961 1.0 1.0 0.0 0 0 0 0 0 GO:0016032 4 viral process 22 23 1 1 1 0 0 0 59 23 2465 0.58192 1.0 1.0 0.0 0 0 0 0 0 GO:0016104 7 triterpenoid biosynthetic process 1 1 1 1 0 0 0 0 59 1 2487 0.97684 1.0 1.0 0.0 0 0 0 0 0 GO:0016127 6 sterol catabolic process 4 4 1 1 1 0 0 0 59 4 2484 0.91046 1.0 1.0 0.0 0 0 0 0 0 GO:0016202 6 regulation of striated muscle tissue development 55 57 1 1 1 0 0 0 59 57 2431 0.25898 1.0 0.64188 0.0 0 0 0 0 0 GO:0016264 8 gap junction assembly 2 2 1 1 1 0 0 0 59 2 2486 0.9542 1.0 1.0 0.0 0 0 0 0 0 GO:0016311 6 dephosphorylation 44 50 1 1 1 0 0 0 59 50 2438 0.30623 1.0 0.62961 0.0 0 0 0 0 0 GO:0017038 6 protein import 28 30 1 1 1 0 0 0 59 30 2458 0.49303 1.0 1.0 0.0 0 0 0 0 0 GO:0017148 8 negative regulation of translation 21 22 1 1 0 1 0 0 59 22 2466 0.59584 1.0 1.0 0.0 0 0 0 0 0 GO:0017185 8 peptidyl-lysine hydroxylation 4 4 1 1 0 0 0 0 59 4 2484 0.91046 1.0 1.0 0.0 0 0 0 0 0 GO:0018126 7 protein hydroxylation 9 9 1 1 0 0 0 0 59 9 2479 0.80956 1.0 1.0 0.0 0 0 0 0 0 GO:0018193 7 peptidyl-amino acid modification 169 184 1 1 0 0 0 0 59 184 2304 0.011365 1.0 0.019797 0.0 0 0 0 0 0 GO:0018205 8 peptidyl-lysine modification 36 39 1 1 0 0 0 0 59 39 2449 0.39812 1.0 1.0 0.0 0 0 0 0 0 GO:0018931 5 naphthalene metabolic process 1 1 1 1 1 0 0 0 59 1 2487 0.97684 1.0 1.0 0.0 0 0 0 0 0 GO:0018979 5 trichloroethylene metabolic process 1 1 1 1 1 0 0 0 59 1 2487 0.97684 1.0 1.0 0.0 0 0 0 0 0 GO:0019068 5 virion assembly 3 3 1 1 1 0 0 0 59 3 2485 0.93208 1.0 1.0 0.0 0 0 0 0 0 GO:0019229 7 regulation of vasoconstriction 30 31 1 1 1 0 0 0 59 31 2457 0.48147 1.0 1.0 0.0 0 0 0 0 0 GO:0019934 8 cGMP-mediated signaling 4 5 1 1 1 0 0 0 59 5 2483 0.88934 1.0 1.0 0.0 0 0 0 0 0 GO:0021782 5 glial cell development 22 22 1 1 1 0 0 0 59 22 2466 0.59584 1.0 1.0 0.0 0 0 0 0 0 GO:0022602 3 ovulation cycle process 24 29 1 1 0 1 0 0 59 29 2459 0.50486 1.0 1.0 0.0 0 0 0 0 0 GO:0022898 5 regulation of transmembrane transporter activity 58 60 1 1 1 0 0 0 59 60 2428 0.241 1.0 0.40147 0.0 0 0 0 0 0 GO:0030098 5 lymphocyte differentiation 53 58 1 1 1 0 0 0 59 58 2430 0.25285 1.0 0.64408 0.0 0 0 0 0 0 GO:0030099 5 myeloid cell differentiation 58 64 1 1 0 1 0 0 59 64 2424 0.21892 1.0 0.40241 0.0 0 0 0 0 0 GO:0030111 6 regulation of Wnt signaling pathway 60 63 1 1 1 0 0 0 59 63 2425 0.22424 1.0 0.40189 0.0 0 0 0 0 0 GO:0030178 7 negative regulation of Wnt signaling pathway 31 31 1 1 1 0 0 0 59 31 2457 0.48147 1.0 1.0 0.0 0 0 0 0 0 GO:0030193 5 regulation of blood coagulation 45 46 1 1 1 0 0 0 59 46 2442 0.33694 1.0 0.62569 0.0 0 0 0 0 0 GO:0030195 6 negative regulation of blood coagulation 26 26 1 1 1 0 0 0 59 26 2462 0.54204 1.0 1.0 0.0 0 0 0 0 0 GO:0030198 6 extracellular matrix organization 60 68 1 1 1 0 0 0 59 68 2420 0.19883 1.0 0.40618 0.0 0 0 0 0 0 GO:0030199 6 collagen fibril organization 14 16 1 1 1 0 0 0 59 16 2472 0.68652 1.0 1.0 0.0 0 0 0 0 0 GO:0030217 6 T cell differentiation 40 44 1 1 1 0 0 0 59 44 2444 0.35341 1.0 0.62477 0.0 0 0 0 0 0 GO:0030224 7 monocyte differentiation 8 8 1 1 0 1 0 0 59 8 2480 0.82882 1.0 1.0 0.0 0 0 0 0 0 GO:0030278 5 regulation of ossification 54 58 2 2 2 0 0 0 59 58 2430 0.25285 1.0 0.64408 0.0 0 0 0 0 0 GO:0030279 6 negative regulation of ossification 16 19 1 1 1 0 0 0 59 19 2469 0.63961 1.0 1.0 0.0 0 0 0 0 0 GO:0030301 8 cholesterol transport 18 18 1 1 1 0 0 0 59 18 2470 0.65488 1.0 1.0 0.0 0 0 0 0 0 GO:0030330 7 DNA damage response, signal transduction by p53 class mediator 13 14 1 1 1 0 0 0 59 14 2474 0.71967 1.0 1.0 0.0 0 0 0 0 0 GO:0030336 7 negative regulation of cell migration 73 78 2 2 2 0 0 0 59 78 2410 0.1562 1.0 0.26067 0.0 0 0 0 0 0 GO:0030500 6 regulation of bone mineralization 18 20 2 2 2 0 0 0 59 20 2468 0.62468 1.0 1.0 0.0 0 0 0 0 0 GO:0030502 7 negative regulation of bone mineralization 4 5 1 1 1 0 0 0 59 5 2483 0.88934 1.0 1.0 0.0 0 0 0 0 0 GO:0030510 6 regulation of BMP signaling pathway 17 19 1 0 1 0 0 0 59 19 2469 0.63961 1.0 1.0 0.0 0 0 0 0 0 GO:0030512 8 negative regulation of transforming growth factor beta receptor signaling pathway 19 20 1 1 1 0 0 0 59 20 2468 0.62468 1.0 1.0 0.0 0 0 0 0 0 GO:0031623 7 receptor internalization 21 22 1 1 0 1 0 0 59 22 2466 0.59584 1.0 1.0 0.0 0 0 0 0 0 GO:0031952 9 regulation of protein autophosphorylation 18 21 1 1 0 1 0 0 59 21 2467 0.61009 1.0 1.0 0.0 0 0 0 0 0 GO:0031953 10 negative regulation of protein autophosphorylation 7 8 1 1 0 1 0 0 59 8 2480 0.82882 1.0 1.0 0.0 0 0 0 0 0 GO:0032006 7 regulation of TOR signaling 19 20 1 1 1 0 0 0 59 20 2468 0.62468 1.0 1.0 0.0 0 0 0 0 0 GO:0032007 8 negative regulation of TOR signaling 11 11 1 1 1 0 0 0 59 11 2477 0.77235 1.0 1.0 0.0 0 0 0 0 0 GO:0032024 8 positive regulation of insulin secretion 27 29 1 1 1 0 0 0 59 29 2459 0.50486 1.0 1.0 0.0 0 0 0 0 0 GO:0032069 6 regulation of nuclease activity 9 10 1 1 0 0 0 0 59 10 2478 0.79074 1.0 1.0 0.0 0 0 0 0 0 GO:0032075 7 positive regulation of nuclease activity 6 6 1 1 0 0 0 0 59 6 2482 0.8687 1.0 1.0 0.0 0 0 0 0 0 GO:0032092 6 positive regulation of protein binding 30 33 1 1 1 0 0 0 59 33 2455 0.45915 1.0 1.0 0.0 0 0 0 0 0 GO:0032231 6 regulation of actin filament bundle assembly 27 30 1 1 1 0 0 0 59 30 2458 0.49303 1.0 1.0 0.0 0 0 0 0 0 GO:0032233 7 positive regulation of actin filament bundle assembly 21 24 1 1 1 0 0 0 59 24 2464 0.56832 1.0 1.0 0.0 0 0 0 0 0 GO:0032276 6 regulation of gonadotropin secretion 5 5 1 1 1 0 0 0 59 5 2483 0.88934 1.0 1.0 0.0 0 0 0 0 0 GO:0032277 7 negative regulation of gonadotropin secretion 3 3 1 1 1 0 0 0 59 3 2485 0.93208 1.0 1.0 0.0 0 0 0 0 0 GO:0032369 6 negative regulation of lipid transport 13 14 1 1 1 0 0 0 59 14 2474 0.71967 1.0 1.0 0.0 0 0 0 0 0 GO:0032371 7 regulation of sterol transport 17 18 1 1 1 0 0 0 59 18 2470 0.65488 1.0 1.0 0.0 0 0 0 0 0 GO:0032372 7 negative regulation of sterol transport 6 7 1 1 1 0 0 0 59 7 2481 0.84853 1.0 1.0 0.0 0 0 0 0 0 GO:0032373 7 positive regulation of sterol transport 12 12 1 1 1 0 0 0 59 12 2476 0.75438 1.0 1.0 0.0 0 0 0 0 0 GO:0032374 8 regulation of cholesterol transport 17 18 1 1 1 0 0 0 59 18 2470 0.65488 1.0 1.0 0.0 0 0 0 0 0 GO:0032375 8 negative regulation of cholesterol transport 6 7 1 1 1 0 0 0 59 7 2481 0.84853 1.0 1.0 0.0 0 0 0 0 0 GO:0032376 8 positive regulation of cholesterol transport 12 12 1 1 1 0 0 0 59 12 2476 0.75438 1.0 1.0 0.0 0 0 0 0 0 GO:0032409 4 regulation of transporter activity 61 63 1 1 1 0 0 0 59 63 2425 0.22424 1.0 0.40189 0.0 0 0 0 0 0 GO:0032465 6 regulation of cytokinesis 27 28 2 2 1 1 0 0 59 28 2460 0.51696 1.0 1.0 0.0 0 0 0 0 0 GO:0032466 7 negative regulation of cytokinesis 3 3 1 1 1 0 0 0 59 3 2485 0.93208 1.0 1.0 0.0 0 0 0 0 0 GO:0032479 6 regulation of type I interferon production 21 21 1 1 0 0 0 0 59 21 2467 0.61009 1.0 1.0 0.0 0 0 0 0 0 GO:0032481 7 positive regulation of type I interferon production 16 16 1 1 0 0 0 0 59 16 2472 0.68652 1.0 1.0 0.0 0 0 0 0 0 GO:0032489 10 regulation of Cdc42 protein signal transduction 4 5 1 1 1 0 0 0 59 5 2483 0.88934 1.0 1.0 0.0 0 0 0 0 0 GO:0032506 4 cytokinetic process 6 9 1 1 0 1 0 0 59 9 2479 0.80956 1.0 1.0 0.0 0 0 0 0 0 GO:0032507 5 maintenance of protein location in cell 15 15 1 1 1 0 0 0 59 15 2473 0.7029 1.0 1.0 0.0 0 0 0 0 0 GO:0032648 7 regulation of interferon-beta production 16 16 1 1 0 0 0 0 59 16 2472 0.68652 1.0 1.0 0.0 0 0 0 0 0 GO:0032728 8 positive regulation of interferon-beta production 12 12 1 1 0 0 0 0 59 12 2476 0.75438 1.0 1.0 0.0 0 0 0 0 0 GO:0032782 7 bile acid secretion 3 3 1 1 1 0 0 0 59 3 2485 0.93208 1.0 1.0 0.0 0 0 0 0 0 GO:0032803 7 regulation of low-density lipoprotein particle receptor catabolic process 2 2 1 1 1 0 0 0 59 2 2486 0.9542 1.0 1.0 0.0 0 0 0 0 0 GO:0032805 8 positive regulation of low-density lipoprotein particle receptor catabolic process 1 1 1 1 1 0 0 0 59 1 2487 0.97684 1.0 1.0 0.0 0 0 0 0 0 GO:0032875 7 regulation of DNA endoreduplication 2 2 1 1 1 0 0 0 59 2 2486 0.9542 1.0 1.0 0.0 0 0 0 0 0 GO:0032877 8 positive regulation of DNA endoreduplication 2 2 1 1 1 0 0 0 59 2 2486 0.9542 1.0 1.0 0.0 0 0 0 0 0 GO:0032941 5 secretion by tissue 4 4 1 1 1 0 0 0 59 4 2484 0.91046 1.0 1.0 0.0 0 0 0 0 0 GO:0032943 5 mononuclear cell proliferation 30 34 1 1 1 0 0 0 59 34 2454 0.44837 1.0 1.0 0.0 0 0 0 0 0 GO:0032956 6 regulation of actin cytoskeleton organization 79 82 1 1 1 0 0 0 59 82 2406 0.14179 1.0 0.2616 0.0 0 0 0 0 0 GO:0032970 5 regulation of actin filament-based process 88 91 1 1 1 0 0 0 59 91 2397 0.11397 1.0 0.27162 0.0 0 0 0 0 0 GO:0032984 6 protein-containing complex disassembly 18 21 1 1 1 0 0 0 59 21 2467 0.61009 1.0 1.0 0.0 0 0 0 0 0 GO:0033077 7 T cell differentiation in thymus 14 17 1 1 1 0 0 0 59 17 2471 0.67052 1.0 1.0 0.0 0 0 0 0 0 GO:0033135 9 regulation of peptidyl-serine phosphorylation 38 46 1 1 1 0 0 0 59 46 2442 0.33694 1.0 0.62569 0.0 0 0 0 0 0 GO:0033137 10 negative regulation of peptidyl-serine phosphorylation 12 12 1 1 1 0 0 0 59 12 2476 0.75438 1.0 1.0 0.0 0 0 0 0 0 GO:0033206 4 meiotic cytokinesis 4 4 1 1 0 1 0 0 59 4 2484 0.91046 1.0 1.0 0.0 0 0 0 0 0 GO:0033344 9 cholesterol efflux 12 12 1 1 1 0 0 0 59 12 2476 0.75438 1.0 1.0 0.0 0 0 0 0 0 GO:0033700 8 phospholipid efflux 5 5 1 1 1 0 0 0 59 5 2483 0.88934 1.0 1.0 0.0 0 0 0 0 0 GO:0034063 7 stress granule assembly 4 4 1 1 0 1 0 0 59 4 2484 0.91046 1.0 1.0 0.0 0 0 0 0 0 GO:0034103 5 regulation of tissue remodeling 28 28 2 2 2 0 0 0 59 28 2460 0.51696 1.0 1.0 0.0 0 0 0 0 0 GO:0034105 6 positive regulation of tissue remodeling 16 16 1 1 1 0 0 0 59 16 2472 0.68652 1.0 1.0 0.0 0 0 0 0 0 GO:0034219 5 carbohydrate transmembrane transport 6 8 1 1 0 1 0 0 59 8 2480 0.82882 1.0 1.0 0.0 0 0 0 0 0 GO:0034248 6 regulation of cellular amide metabolic process 83 90 2 2 1 1 0 0 59 90 2398 0.11677 1.0 0.27001 0.0 0 0 0 0 0 GO:0034249 7 negative regulation of cellular amide metabolic process 28 29 2 2 1 1 0 0 59 29 2459 0.50486 1.0 1.0 0.0 0 0 0 0 0 GO:0034250 7 positive regulation of cellular amide metabolic process 35 39 1 1 1 0 0 0 59 39 2449 0.39812 1.0 1.0 0.0 0 0 0 0 0 GO:0034367 6 protein-containing complex remodeling 10 10 1 1 1 0 0 0 59 10 2478 0.79074 1.0 1.0 0.0 0 0 0 0 0 GO:0034368 7 protein-lipid complex remodeling 10 10 1 1 1 0 0 0 59 10 2478 0.79074 1.0 1.0 0.0 0 0 0 0 0 GO:0034369 7 plasma lipoprotein particle remodeling 10 10 1 1 1 0 0 0 59 10 2478 0.79074 1.0 1.0 0.0 0 0 0 0 0 GO:0034370 8 triglyceride-rich lipoprotein particle remodeling 5 5 1 1 1 0 0 0 59 5 2483 0.88934 1.0 1.0 0.0 0 0 0 0 0 GO:0034372 9 very-low-density lipoprotein particle remodeling 4 4 1 1 1 0 0 0 59 4 2484 0.91046 1.0 1.0 0.0 0 0 0 0 0 GO:0034374 8 low-density lipoprotein particle remodeling 3 3 1 1 1 0 0 0 59 3 2485 0.93208 1.0 1.0 0.0 0 0 0 0 0 GO:0034375 8 high-density lipoprotein particle remodeling 8 8 1 1 1 0 0 0 59 8 2480 0.82882 1.0 1.0 0.0 0 0 0 0 0 GO:0034377 7 plasma lipoprotein particle assembly 7 7 1 1 1 0 0 0 59 7 2481 0.84853 1.0 1.0 0.0 0 0 0 0 0 GO:0034380 8 high-density lipoprotein particle assembly 4 4 1 1 1 0 0 0 59 4 2484 0.91046 1.0 1.0 0.0 0 0 0 0 0 GO:0034381 3 plasma lipoprotein particle clearance 11 11 1 1 1 0 0 0 59 11 2477 0.77235 1.0 1.0 0.0 0 0 0 0 0 GO:0034382 5 chylomicron remnant clearance 4 4 1 1 1 0 0 0 59 4 2484 0.91046 1.0 1.0 0.0 0 0 0 0 0 GO:0034384 4 high-density lipoprotein particle clearance 5 5 1 1 1 0 0 0 59 5 2483 0.88934 1.0 1.0 0.0 0 0 0 0 0 GO:0034405 4 response to fluid shear stress 18 20 1 1 1 0 0 0 59 20 2468 0.62468 1.0 1.0 0.0 0 0 0 0 0 GO:0034447 4 very-low-density lipoprotein particle clearance 3 3 1 1 1 0 0 0 59 3 2485 0.93208 1.0 1.0 0.0 0 0 0 0 0 GO:0034599 5 cellular response to oxidative stress 95 101 2 2 1 1 0 0 59 101 2387 0.089327 1.0 0.17135 0.0 0 0 0 0 0 GO:0034614 6 cellular response to reactive oxygen species 66 70 2 2 1 1 0 0 59 70 2418 0.18947 1.0 0.40902 0.0 0 0 0 0 0 GO:0034635 6 glutathione transport 3 3 1 1 1 0 0 0 59 3 2485 0.93208 1.0 1.0 0.0 0 0 0 0 0 GO:0034728 6 nucleosome organization 18 25 1 1 0 0 0 0 59 25 2463 0.55503 1.0 1.0 0.0 0 0 0 0 0 GO:0034775 6 glutathione transmembrane transport 2 2 1 1 1 0 0 0 59 2 2486 0.9542 1.0 1.0 0.0 0 0 0 0 0 GO:0034976 5 response to endoplasmic reticulum stress 55 58 1 1 0 1 0 0 59 58 2430 0.25285 1.0 0.64408 0.0 0 0 0 0 0 GO:0035023 9 regulation of Rho protein signal transduction 18 19 2 2 1 0 0 0 59 19 2469 0.63961 1.0 1.0 0.0 0 0 0 0 0 GO:0035025 10 positive regulation of Rho protein signal transduction 9 9 1 1 0 0 0 0 59 9 2479 0.80956 1.0 1.0 0.0 0 0 0 0 0 GO:0035026 6 leading edge cell differentiation 2 2 1 1 0 1 0 0 59 2 2486 0.9542 1.0 1.0 0.0 0 0 0 0 0 GO:0035050 5 embryonic heart tube development 2 2 1 1 1 0 0 0 59 2 2486 0.9542 1.0 1.0 0.0 0 0 0 0 0 GO:0035051 5 cardiocyte differentiation 10 10 1 1 1 0 0 0 59 10 2478 0.79074 1.0 1.0 0.0 0 0 0 0 0 GO:0035150 5 regulation of tube size 54 57 2 2 2 0 0 0 59 57 2431 0.25898 1.0 0.64188 0.0 0 0 0 0 0 GO:0035296 6 regulation of tube diameter 54 57 2 2 2 0 0 0 59 57 2431 0.25898 1.0 0.64188 0.0 0 0 0 0 0 GO:0035303 8 regulation of dephosphorylation 40 45 1 1 1 0 0 0 59 45 2443 0.34508 1.0 0.62513 0.0 0 0 0 0 0 GO:0035306 9 positive regulation of dephosphorylation 19 21 1 1 1 0 0 0 59 21 2467 0.61009 1.0 1.0 0.0 0 0 0 0 0 GO:0035437 7 maintenance of protein localization in endoplasmic reticulum 4 4 1 1 1 0 0 0 59 4 2484 0.91046 1.0 1.0 0.0 0 0 0 0 0 GO:0035443 6 tripeptide transmembrane transport 2 2 1 1 1 0 0 0 59 2 2486 0.9542 1.0 1.0 0.0 0 0 0 0 0 GO:0035519 11 protein K29-linked ubiquitination 1 1 1 1 0 1 0 0 59 1 2487 0.97684 1.0 1.0 0.0 0 0 0 0 0 GO:0035581 8 sequestering of extracellular ligand from receptor 2 2 1 1 1 0 0 0 59 2 2486 0.9542 1.0 1.0 0.0 0 0 0 0 0 GO:0035583 7 sequestering of TGFbeta in extracellular matrix 2 2 1 1 1 0 0 0 59 2 2486 0.9542 1.0 1.0 0.0 0 0 0 0 0 GO:0035637 3 multicellular organismal signaling 10 10 1 1 1 0 0 0 59 10 2478 0.79074 1.0 1.0 0.0 0 0 0 0 0 GO:0035640 3 exploration behavior 5 5 1 1 1 0 0 0 59 5 2483 0.88934 1.0 1.0 0.0 0 0 0 0 0 GO:0035641 4 locomotory exploration behavior 3 3 1 1 1 0 0 0 59 3 2485 0.93208 1.0 1.0 0.0 0 0 0 0 0 GO:0035672 5 oligopeptide transmembrane transport 4 4 1 1 1 0 0 0 59 4 2484 0.91046 1.0 1.0 0.0 0 0 0 0 0 GO:0035994 5 response to muscle stretch 14 14 1 1 0 1 0 0 59 14 2474 0.71967 1.0 1.0 0.0 0 0 0 0 0 GO:0036119 4 response to platelet-derived growth factor 12 13 1 1 1 0 0 0 59 13 2475 0.73682 1.0 1.0 0.0 0 0 0 0 0 GO:0036120 6 cellular response to platelet-derived growth factor stimulus 12 13 1 1 1 0 0 0 59 13 2475 0.73682 1.0 1.0 0.0 0 0 0 0 0 GO:0036314 5 response to sterol 18 18 1 1 1 0 0 0 59 18 2470 0.65488 1.0 1.0 0.0 0 0 0 0 0 GO:0036315 6 cellular response to sterol 9 9 1 1 1 0 0 0 59 9 2479 0.80956 1.0 1.0 0.0 0 0 0 0 0 GO:0036363 3 transforming growth factor beta activation 1 1 1 1 1 0 0 0 59 1 2487 0.97684 1.0 1.0 0.0 0 0 0 0 0 GO:0036364 4 transforming growth factor beta1 activation 1 1 1 1 1 0 0 0 59 1 2487 0.97684 1.0 1.0 0.0 0 0 0 0 0 GO:0038061 6 NIK/NF-kappaB signaling 8 8 1 1 1 0 0 0 59 8 2480 0.82882 1.0 1.0 0.0 0 0 0 0 0 GO:0038179 6 neurotrophin signaling pathway 9 10 1 1 1 0 0 0 59 10 2478 0.79074 1.0 1.0 0.0 0 0 0 0 0 GO:0040001 7 establishment of mitotic spindle localization 10 10 1 1 1 0 0 0 59 10 2478 0.79074 1.0 1.0 0.0 0 0 0 0 0 GO:0040013 5 negative regulation of locomotion 80 86 2 2 2 0 0 0 59 86 2402 0.12868 1.0 0.26478 0.0 0 0 0 0 0 GO:0040019 6 positive regulation of embryonic development 15 15 1 1 1 0 0 0 59 15 2473 0.7029 1.0 1.0 0.0 0 0 0 0 0 GO:0040038 4 polar body extrusion after meiotic divisions 4 4 1 1 0 1 0 0 59 4 2484 0.91046 1.0 1.0 0.0 0 0 0 0 0 GO:0042098 6 T cell proliferation 19 21 1 1 1 0 0 0 59 21 2467 0.61009 1.0 1.0 0.0 0 0 0 0 0 GO:0042126 5 nitrate metabolic process 2 2 1 1 1 0 0 0 59 2 2486 0.9542 1.0 1.0 0.0 0 0 0 0 0 GO:0042157 5 lipoprotein metabolic process 11 11 1 1 1 0 0 0 59 11 2477 0.77235 1.0 1.0 0.0 0 0 0 0 0 GO:0042158 6 lipoprotein biosynthetic process 3 3 1 1 1 0 0 0 59 3 2485 0.93208 1.0 1.0 0.0 0 0 0 0 0 GO:0042159 6 lipoprotein catabolic process 4 4 1 1 1 0 0 0 59 4 2484 0.91046 1.0 1.0 0.0 0 0 0 0 0 GO:0042196 5 chlorinated hydrocarbon metabolic process 1 2 1 1 1 0 0 0 59 2 2486 0.9542 1.0 1.0 0.0 0 0 0 0 0 GO:0042197 4 halogenated hydrocarbon metabolic process 1 2 1 1 1 0 0 0 59 2 2486 0.9542 1.0 1.0 0.0 0 0 0 0 0 GO:0042311 8 vasodilation 12 13 1 1 1 0 0 0 59 13 2475 0.73682 1.0 1.0 0.0 0 0 0 0 0 GO:0042554 6 superoxide anion generation 6 6 1 1 1 0 0 0 59 6 2482 0.8687 1.0 1.0 0.0 0 0 0 0 0 GO:0042632 8 cholesterol homeostasis 34 35 1 1 1 0 0 0 59 35 2453 0.43785 1.0 1.0 0.0 0 0 0 0 0 GO:0042770 6 signal transduction in response to DNA damage 22 24 1 1 1 0 0 0 59 24 2464 0.56832 1.0 1.0 0.0 0 0 0 0 0 GO:0042771 8 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 12 12 1 1 1 0 0 0 59 12 2476 0.75438 1.0 1.0 0.0 0 0 0 0 0 GO:0042939 8 tripeptide transport 3 3 1 1 1 0 0 0 59 3 2485 0.93208 1.0 1.0 0.0 0 0 0 0 0 GO:0043029 7 T cell homeostasis 12 13 1 1 1 0 0 0 59 13 2475 0.73682 1.0 1.0 0.0 0 0 0 0 0 GO:0043062 5 extracellular structure organization 60 68 1 1 1 0 0 0 59 68 2420 0.19883 1.0 0.40618 0.0 0 0 0 0 0 GO:0043087 6 regulation of GTPase activity 76 81 1 1 0 1 0 0 59 81 2407 0.14526 1.0 0.26115 0.0 0 0 0 0 0 GO:0043113 5 receptor clustering 15 15 1 1 1 0 0 0 59 15 2473 0.7029 1.0 1.0 0.0 0 0 0 0 0 GO:0043388 6 positive regulation of DNA binding 21 22 1 1 0 0 0 0 59 22 2466 0.59584 1.0 1.0 0.0 0 0 0 0 0 GO:0043403 5 skeletal muscle tissue regeneration 10 10 1 1 1 0 0 0 59 10 2478 0.79074 1.0 1.0 0.0 0 0 0 0 0 GO:0043413 4 macromolecule glycosylation 32 33 1 1 0 0 0 0 59 33 2455 0.45915 1.0 1.0 0.0 0 0 0 0 0 GO:0043467 6 regulation of generation of precursor metabolites and energy 45 48 1 1 1 0 0 0 59 48 2440 0.32123 1.0 0.62732 0.0 0 0 0 0 0 GO:0043470 6 regulation of carbohydrate catabolic process 24 25 1 1 1 0 0 0 59 25 2463 0.55503 1.0 1.0 0.0 0 0 0 0 0 GO:0043537 8 negative regulation of blood vessel endothelial cell migration 13 14 1 1 1 0 0 0 59 14 2474 0.71967 1.0 1.0 0.0 0 0 0 0 0 GO:0043547 7 positive regulation of GTPase activity 63 68 1 1 0 1 0 0 59 68 2420 0.19883 1.0 0.40618 0.0 0 0 0 0 0 GO:0043588 5 skin development 13 14 1 1 1 0 0 0 59 14 2474 0.71967 1.0 1.0 0.0 0 0 0 0 0 GO:0043691 9 reverse cholesterol transport 7 7 1 1 1 0 0 0 59 7 2481 0.84853 1.0 1.0 0.0 0 0 0 0 0 GO:0043900 4 regulation of multi-organism process 30 31 1 1 1 0 0 0 59 31 2457 0.48147 1.0 1.0 0.0 0 0 0 0 0 GO:0043901 5 negative regulation of multi-organism process 11 12 1 1 1 0 0 0 59 12 2476 0.75438 1.0 1.0 0.0 0 0 0 0 0 GO:0043923 6 positive regulation by host of viral transcription 6 6 1 1 0 1 0 0 59 6 2482 0.8687 1.0 1.0 0.0 0 0 0 0 0 GO:0044314 11 protein K27-linked ubiquitination 1 1 1 1 0 1 0 0 59 1 2487 0.97684 1.0 1.0 0.0 0 0 0 0 0 GO:0044403 3 symbiotic process 38 40 1 1 1 0 0 0 59 40 2448 0.38875 1.0 1.0 0.0 0 0 0 0 0 GO:0044788 5 modulation by host of viral process 11 12 1 1 1 0 0 0 59 12 2476 0.75438 1.0 1.0 0.0 0 0 0 0 0 GO:0044794 6 positive regulation by host of viral process 8 9 1 1 1 0 0 0 59 9 2479 0.80956 1.0 1.0 0.0 0 0 0 0 0 GO:0045071 7 negative regulation of viral genome replication 17 18 1 1 1 0 0 0 59 18 2470 0.65488 1.0 1.0 0.0 0 0 0 0 0 GO:0045124 5 regulation of bone resorption 18 18 1 1 1 0 0 0 59 18 2470 0.65488 1.0 1.0 0.0 0 0 0 0 0 GO:0045185 4 maintenance of protein location 25 26 2 2 2 0 0 0 59 26 2462 0.54204 1.0 1.0 0.0 0 0 0 0 0 GO:0045453 7 bone resorption 12 12 1 1 1 0 0 0 59 12 2476 0.75438 1.0 1.0 0.0 0 0 0 0 0 GO:0045541 8 negative regulation of cholesterol biosynthetic process 2 2 1 1 1 0 0 0 59 2 2486 0.9542 1.0 1.0 0.0 0 0 0 0 0 GO:0045639 7 positive regulation of myeloid cell differentiation 40 45 2 2 0 1 0 0 59 45 2443 0.34508 1.0 0.62513 0.0 0 0 0 0 0 GO:0045646 5 regulation of erythrocyte differentiation 19 21 1 1 0 0 0 0 59 21 2467 0.61009 1.0 1.0 0.0 0 0 0 0 0 GO:0045648 6 positive regulation of erythrocyte differentiation 15 16 1 1 0 0 0 0 59 16 2472 0.68652 1.0 1.0 0.0 0 0 0 0 0 GO:0045652 7 regulation of megakaryocyte differentiation 7 8 1 1 0 0 0 0 59 8 2480 0.82882 1.0 1.0 0.0 0 0 0 0 0 GO:0045654 8 positive regulation of megakaryocyte differentiation 2 2 1 1 0 0 0 0 59 2 2486 0.9542 1.0 1.0 0.0 0 0 0 0 0 GO:0045655 8 regulation of monocyte differentiation 7 7 1 1 0 1 0 0 59 7 2481 0.84853 1.0 1.0 0.0 0 0 0 0 0 GO:0045657 9 positive regulation of monocyte differentiation 4 4 1 1 0 1 0 0 59 4 2484 0.91046 1.0 1.0 0.0 0 0 0 0 0 GO:0045773 8 positive regulation of axon extension 16 16 1 1 1 0 0 0 59 16 2472 0.68652 1.0 1.0 0.0 0 0 0 0 0 GO:0045780 6 positive regulation of bone resorption 11 11 1 1 1 0 0 0 59 11 2477 0.77235 1.0 1.0 0.0 0 0 0 0 0 GO:0045820 7 negative regulation of glycolytic process 7 7 1 1 1 0 0 0 59 7 2481 0.84853 1.0 1.0 0.0 0 0 0 0 0 GO:0045843 7 negative regulation of striated muscle tissue development 21 21 1 1 1 0 0 0 59 21 2467 0.61009 1.0 1.0 0.0 0 0 0 0 0 GO:0045844 7 positive regulation of striated muscle tissue development 30 32 1 1 1 0 0 0 59 32 2456 0.47018 1.0 1.0 0.0 0 0 0 0 0 GO:0045907 7 positive regulation of vasoconstriction 19 20 1 1 1 0 0 0 59 20 2468 0.62468 1.0 1.0 0.0 0 0 0 0 0 GO:0045912 6 negative regulation of carbohydrate metabolic process 20 23 1 1 1 0 0 0 59 23 2465 0.58192 1.0 1.0 0.0 0 0 0 0 0 GO:0045939 7 negative regulation of steroid metabolic process 5 5 1 1 1 0 0 0 59 5 2483 0.88934 1.0 1.0 0.0 0 0 0 0 0 GO:0045980 7 negative regulation of nucleotide metabolic process 8 9 1 1 1 0 0 0 59 9 2479 0.80956 1.0 1.0 0.0 0 0 0 0 0 GO:0045992 6 negative regulation of embryonic development 7 8 1 1 1 0 0 0 59 8 2480 0.82882 1.0 1.0 0.0 0 0 0 0 0 GO:0045995 6 regulation of embryonic development 34 36 2 2 2 0 0 0 59 36 2452 0.42756 1.0 1.0 0.0 0 0 0 0 0 GO:0046006 9 regulation of activated T cell proliferation 9 9 1 1 1 0 0 0 59 9 2479 0.80956 1.0 1.0 0.0 0 0 0 0 0 GO:0046164 5 alcohol catabolic process 12 13 1 1 1 0 0 0 59 13 2475 0.73682 1.0 1.0 0.0 0 0 0 0 0 GO:0046578 8 regulation of Ras protein signal transduction 34 36 2 2 1 0 0 0 59 36 2452 0.42756 1.0 1.0 0.0 0 0 0 0 0 GO:0046579 9 positive regulation of Ras protein signal transduction 15 16 1 1 0 0 0 0 59 16 2472 0.68652 1.0 1.0 0.0 0 0 0 0 0 GO:0046620 5 regulation of organ growth 36 37 1 1 1 0 0 0 59 37 2451 0.41752 1.0 1.0 0.0 0 0 0 0 0 GO:0046621 6 negative regulation of organ growth 14 14 1 1 1 0 0 0 59 14 2474 0.71967 1.0 1.0 0.0 0 0 0 0 0 GO:0046651 5 lymphocyte proliferation 29 33 1 1 1 0 0 0 59 33 2455 0.45915 1.0 1.0 0.0 0 0 0 0 0 GO:0046697 4 decidualization 10 11 1 1 1 0 0 0 59 11 2477 0.77235 1.0 1.0 0.0 0 0 0 0 0 GO:0046777 8 protein autophosphorylation 52 55 1 1 1 0 0 0 59 55 2433 0.2717 1.0 0.63777 0.0 0 0 0 0 0 GO:0046849 4 bone remodeling 6 6 1 1 1 0 0 0 59 6 2482 0.8687 1.0 1.0 0.0 0 0 0 0 0 GO:0046850 6 regulation of bone remodeling 20 20 2 2 2 0 0 0 59 20 2468 0.62468 1.0 1.0 0.0 0 0 0 0 0 GO:0046852 7 positive regulation of bone remodeling 11 11 1 1 1 0 0 0 59 11 2477 0.77235 1.0 1.0 0.0 0 0 0 0 0 GO:0046887 6 positive regulation of hormone secretion 46 50 1 1 1 0 0 0 59 50 2438 0.30623 1.0 0.62961 0.0 0 0 0 0 0 GO:0048011 7 neurotrophin TRK receptor signaling pathway 6 7 1 1 1 0 0 0 59 7 2481 0.84853 1.0 1.0 0.0 0 0 0 0 0 GO:0048145 6 regulation of fibroblast proliferation 37 41 1 1 0 1 0 0 59 41 2447 0.3796 1.0 1.0 0.0 0 0 0 0 0 GO:0048146 7 positive regulation of fibroblast proliferation 27 30 1 1 0 1 0 0 59 30 2458 0.49303 1.0 1.0 0.0 0 0 0 0 0 GO:0048514 5 blood vessel morphogenesis 31 32 2 2 2 0 0 0 59 32 2456 0.47018 1.0 1.0 0.0 0 0 0 0 0 GO:0048520 5 positive regulation of behavior 10 10 1 1 1 0 0 0 59 10 2478 0.79074 1.0 1.0 0.0 0 0 0 0 0 GO:0048534 5 hematopoietic or lymphoid organ development 55 60 1 1 1 0 0 0 59 60 2428 0.241 1.0 0.40147 0.0 0 0 0 0 0 GO:0048535 6 lymph node development 4 5 1 1 1 0 0 0 59 5 2483 0.88934 1.0 1.0 0.0 0 0 0 0 0 GO:0048536 6 spleen development 11 12 1 1 1 0 0 0 59 12 2476 0.75438 1.0 1.0 0.0 0 0 0 0 0 GO:0048538 6 thymus development 16 19 1 1 1 0 0 0 59 19 2469 0.63961 1.0 1.0 0.0 0 0 0 0 0 GO:0048592 6 eye morphogenesis 16 16 1 1 1 0 0 0 59 16 2472 0.68652 1.0 1.0 0.0 0 0 0 0 0 GO:0048634 6 regulation of muscle organ development 56 58 1 1 1 0 0 0 59 58 2430 0.25285 1.0 0.64408 0.0 0 0 0 0 0 GO:0048635 6 negative regulation of muscle organ development 22 22 1 1 1 0 0 0 59 22 2466 0.59584 1.0 1.0 0.0 0 0 0 0 0 GO:0048636 6 positive regulation of muscle organ development 30 32 1 1 1 0 0 0 59 32 2456 0.47018 1.0 1.0 0.0 0 0 0 0 0 GO:0048709 6 oligodendrocyte differentiation 10 11 1 1 1 0 0 0 59 11 2477 0.77235 1.0 1.0 0.0 0 0 0 0 0 GO:0048771 3 tissue remodeling 36 39 1 1 1 0 0 0 59 39 2449 0.39812 1.0 1.0 0.0 0 0 0 0 0 GO:0048844 6 artery morphogenesis 16 17 1 1 1 0 0 0 59 17 2471 0.67052 1.0 1.0 0.0 0 0 0 0 0 GO:0050434 6 positive regulation of viral transcription 7 7 1 1 0 1 0 0 59 7 2481 0.84853 1.0 1.0 0.0 0 0 0 0 0 GO:0050667 7 homocysteine metabolic process 5 7 1 1 1 0 0 0 59 7 2481 0.84853 1.0 1.0 0.0 0 0 0 0 0 GO:0050680 7 negative regulation of epithelial cell proliferation 40 44 2 2 2 0 0 0 59 44 2444 0.35341 1.0 0.62477 0.0 0 0 0 0 0 GO:0050728 7 negative regulation of inflammatory response 47 48 1 1 1 0 0 0 59 48 2440 0.32123 1.0 0.62732 0.0 0 0 0 0 0 GO:0050730 9 regulation of peptidyl-tyrosine phosphorylation 89 95 2 2 2 0 0 0 59 95 2393 0.1034 1.0 0.16997 0.0 0 0 0 0 0 GO:0050731 10 positive regulation of peptidyl-tyrosine phosphorylation 66 72 1 1 1 0 0 0 59 72 2416 0.18055 1.0 0.41245 0.0 0 0 0 0 0 GO:0050732 10 negative regulation of peptidyl-tyrosine phosphorylation 24 24 1 1 1 0 0 0 59 24 2464 0.56832 1.0 1.0 0.0 0 0 0 0 0 GO:0050772 9 positive regulation of axonogenesis 21 21 1 1 1 0 0 0 59 21 2467 0.61009 1.0 1.0 0.0 0 0 0 0 0 GO:0050795 4 regulation of behavior 19 20 2 2 2 0 0 0 59 20 2468 0.62468 1.0 1.0 0.0 0 0 0 0 0 GO:0050818 5 regulation of coagulation 48 49 1 1 1 0 0 0 59 49 2439 0.31364 1.0 0.62839 0.0 0 0 0 0 0 GO:0050819 6 negative regulation of coagulation 27 27 1 1 1 0 0 0 59 27 2461 0.52936 1.0 1.0 0.0 0 0 0 0 0 GO:0051000 8 positive regulation of nitric-oxide synthase activity 8 10 1 1 1 0 0 0 59 10 2478 0.79074 1.0 1.0 0.0 0 0 0 0 0 GO:0051052 6 regulation of DNA metabolic process 84 88 3 3 2 0 0 0 59 88 2400 0.12259 1.0 0.26715 0.0 0 0 0 0 0 GO:0051053 7 negative regulation of DNA metabolic process 19 19 1 1 1 0 0 0 59 19 2469 0.63961 1.0 1.0 0.0 0 0 0 0 0 GO:0051054 7 positive regulation of DNA metabolic process 56 60 2 2 1 0 0 0 59 60 2428 0.241 1.0 0.40147 0.0 0 0 0 0 0 GO:0051055 7 negative regulation of lipid biosynthetic process 19 19 1 1 1 0 0 0 59 19 2469 0.63961 1.0 1.0 0.0 0 0 0 0 0 GO:0051056 7 regulation of small GTPase mediated signal transduction 38 40 2 2 1 0 0 0 59 40 2448 0.38875 1.0 1.0 0.0 0 0 0 0 0 GO:0051057 8 positive regulation of small GTPase mediated signal transduction 17 18 1 1 0 0 0 0 59 18 2470 0.65488 1.0 1.0 0.0 0 0 0 0 0 GO:0051099 5 positive regulation of binding 56 61 2 2 1 0 0 0 59 61 2427 0.23528 1.0 0.40142 0.0 0 0 0 0 0 GO:0051103 7 DNA ligation involved in DNA repair 2 4 1 1 0 0 0 0 59 4 2484 0.91046 1.0 1.0 0.0 0 0 0 0 0 GO:0051146 6 striated muscle cell differentiation 23 24 1 1 1 0 0 0 59 24 2464 0.56832 1.0 1.0 0.0 0 0 0 0 0 GO:0051181 5 cofactor transport 10 10 1 1 1 0 0 0 59 10 2478 0.79074 1.0 1.0 0.0 0 0 0 0 0 GO:0051225 5 spindle assembly 18 18 1 1 0 1 0 0 59 18 2470 0.65488 1.0 1.0 0.0 0 0 0 0 0 GO:0051271 6 negative regulation of cellular component movement 81 87 2 2 2 0 0 0 59 87 2401 0.1256 1.0 0.2659 0.0 0 0 0 0 0 GO:0051293 6 establishment of spindle localization 10 10 1 1 1 0 0 0 59 10 2478 0.79074 1.0 1.0 0.0 0 0 0 0 0 GO:0051294 7 establishment of spindle orientation 8 8 1 1 1 0 0 0 59 8 2480 0.82882 1.0 1.0 0.0 0 0 0 0 0 GO:0051340 5 regulation of ligase activity 5 5 1 1 1 0 0 0 59 5 2483 0.88934 1.0 1.0 0.0 0 0 0 0 0 GO:0051351 6 positive regulation of ligase activity 4 4 1 1 1 0 0 0 59 4 2484 0.91046 1.0 1.0 0.0 0 0 0 0 0 GO:0051492 7 regulation of stress fiber assembly 24 27 1 1 1 0 0 0 59 27 2461 0.52936 1.0 1.0 0.0 0 0 0 0 0 GO:0051495 8 positive regulation of cytoskeleton organization 51 55 1 1 1 0 0 0 59 55 2433 0.2717 1.0 0.63777 0.0 0 0 0 0 0 GO:0051496 8 positive regulation of stress fiber assembly 18 21 1 1 1 0 0 0 59 21 2467 0.61009 1.0 1.0 0.0 0 0 0 0 0 GO:0051503 9 adenine nucleotide transport 5 5 1 1 1 0 0 0 59 5 2483 0.88934 1.0 1.0 0.0 0 0 0 0 0 GO:0051651 4 maintenance of location in cell 23 23 2 2 2 0 0 0 59 23 2465 0.58192 1.0 1.0 0.0 0 0 0 0 0 GO:0051653 4 spindle localization 12 12 1 1 1 0 0 0 59 12 2476 0.75438 1.0 1.0 0.0 0 0 0 0 0 GO:0051668 4 localization within membrane 22 22 1 1 1 0 0 0 59 22 2466 0.59584 1.0 1.0 0.0 0 0 0 0 0 GO:0051782 6 negative regulation of cell division 7 7 1 1 1 0 0 0 59 7 2481 0.84853 1.0 1.0 0.0 0 0 0 0 0 GO:0051865 10 protein autoubiquitination 13 13 1 1 0 1 0 0 59 13 2475 0.73682 1.0 1.0 0.0 0 0 0 0 0 GO:0051896 7 regulation of protein kinase B signaling 44 47 1 1 1 0 0 0 59 47 2441 0.32899 1.0 0.62642 0.0 0 0 0 0 0 GO:0051897 8 positive regulation of protein kinase B signaling 32 35 1 1 1 0 0 0 59 35 2453 0.43785 1.0 1.0 0.0 0 0 0 0 0 GO:0051899 5 membrane depolarization 10 10 1 1 0 1 0 0 59 10 2478 0.79074 1.0 1.0 0.0 0 0 0 0 0 GO:0055007 6 cardiac muscle cell differentiation 7 7 1 1 1 0 0 0 59 7 2481 0.84853 1.0 1.0 0.0 0 0 0 0 0 GO:0055021 7 regulation of cardiac muscle tissue growth 28 29 1 1 1 0 0 0 59 29 2459 0.50486 1.0 1.0 0.0 0 0 0 0 0 GO:0055022 8 negative regulation of cardiac muscle tissue growth 11 11 1 1 1 0 0 0 59 11 2477 0.77235 1.0 1.0 0.0 0 0 0 0 0 GO:0055024 7 regulation of cardiac muscle tissue development 35 37 1 1 1 0 0 0 59 37 2451 0.41752 1.0 1.0 0.0 0 0 0 0 0 GO:0055026 8 negative regulation of cardiac muscle tissue development 14 14 1 1 1 0 0 0 59 14 2474 0.71967 1.0 1.0 0.0 0 0 0 0 0 GO:0055081 7 anion homeostasis 21 21 1 1 1 0 0 0 59 21 2467 0.61009 1.0 1.0 0.0 0 0 0 0 0 GO:0055088 6 lipid homeostasis 50 52 1 1 1 0 0 0 59 52 2436 0.29193 1.0 0.63248 0.0 0 0 0 0 0 GO:0055089 7 fatty acid homeostasis 7 7 1 1 1 0 0 0 59 7 2481 0.84853 1.0 1.0 0.0 0 0 0 0 0 GO:0055090 7 acylglycerol homeostasis 18 18 1 1 1 0 0 0 59 18 2470 0.65488 1.0 1.0 0.0 0 0 0 0 0 GO:0055092 7 sterol homeostasis 34 35 1 1 1 0 0 0 59 35 2453 0.43785 1.0 1.0 0.0 0 0 0 0 0 GO:0060004 4 reflex 5 5 1 1 1 0 0 0 59 5 2483 0.88934 1.0 1.0 0.0 0 0 0 0 0 GO:0060043 6 regulation of cardiac muscle cell proliferation 14 15 1 1 1 0 0 0 59 15 2473 0.7029 1.0 1.0 0.0 0 0 0 0 0 GO:0060044 7 negative regulation of cardiac muscle cell proliferation 6 6 1 1 1 0 0 0 59 6 2482 0.8687 1.0 1.0 0.0 0 0 0 0 0 GO:0060156 6 milk ejection reflex 1 1 1 1 1 0 0 0 59 1 2487 0.97684 1.0 1.0 0.0 0 0 0 0 0 GO:0060249 5 anatomical structure homeostasis 62 66 1 1 1 0 0 0 59 66 2422 0.20864 1.0 0.40396 0.0 0 0 0 0 0 GO:0060306 5 regulation of membrane repolarization 4 4 1 1 1 0 0 0 59 4 2484 0.91046 1.0 1.0 0.0 0 0 0 0 0 GO:0060307 7 regulation of ventricular cardiac muscle cell membrane repolarization 2 2 1 1 1 0 0 0 59 2 2486 0.9542 1.0 1.0 0.0 0 0 0 0 0 GO:0060348 5 bone development 20 20 1 1 1 0 0 0 59 20 2468 0.62468 1.0 1.0 0.0 0 0 0 0 0 GO:0060371 6 regulation of atrial cardiac muscle cell membrane depolarization 2 2 1 1 1 0 0 0 59 2 2486 0.9542 1.0 1.0 0.0 0 0 0 0 0 GO:0060373 6 regulation of ventricular cardiac muscle cell membrane depolarization 2 2 1 1 1 0 0 0 59 2 2486 0.9542 1.0 1.0 0.0 0 0 0 0 0 GO:0060395 5 SMAD protein signal transduction 24 24 1 1 0 1 0 0 59 24 2464 0.56832 1.0 1.0 0.0 0 0 0 0 0 GO:0060420 6 regulation of heart growth 30 31 1 1 1 0 0 0 59 31 2457 0.48147 1.0 1.0 0.0 0 0 0 0 0 GO:0060544 8 regulation of necroptotic process 10 10 1 1 1 0 0 0 59 10 2478 0.79074 1.0 1.0 0.0 0 0 0 0 0 GO:0060545 9 positive regulation of necroptotic process 2 2 1 1 1 0 0 0 59 2 2486 0.9542 1.0 1.0 0.0 0 0 0 0 0 GO:0060706 4 cell differentiation involved in embryonic placenta development 11 11 1 1 1 0 0 0 59 11 2477 0.77235 1.0 1.0 0.0 0 0 0 0 0 GO:0060707 5 trophoblast giant cell differentiation 6 6 1 1 1 0 0 0 59 6 2482 0.8687 1.0 1.0 0.0 0 0 0 0 0 GO:0060718 5 chorionic trophoblast cell differentiation 4 4 1 1 1 0 0 0 59 4 2484 0.91046 1.0 1.0 0.0 0 0 0 0 0 GO:0060828 7 regulation of canonical Wnt signaling pathway 45 47 1 1 1 0 0 0 59 47 2441 0.32899 1.0 0.62642 0.0 0 0 0 0 0 GO:0060999 10 positive regulation of dendritic spine development 13 14 1 1 1 0 0 0 59 14 2474 0.71967 1.0 1.0 0.0 0 0 0 0 0 GO:0061000 10 negative regulation of dendritic spine development 2 2 1 1 1 0 0 0 59 2 2486 0.9542 1.0 1.0 0.0 0 0 0 0 0 GO:0061029 4 eyelid development in camera-type eye 6 6 1 1 0 1 0 0 59 6 2482 0.8687 1.0 1.0 0.0 0 0 0 0 0 GO:0061045 7 negative regulation of wound healing 33 35 2 2 2 0 0 0 59 35 2453 0.43785 1.0 1.0 0.0 0 0 0 0 0 GO:0061097 8 regulation of protein tyrosine kinase activity 24 26 2 2 2 0 0 0 59 26 2462 0.54204 1.0 1.0 0.0 0 0 0 0 0 GO:0061098 9 positive regulation of protein tyrosine kinase activity 12 14 1 1 1 0 0 0 59 14 2474 0.71967 1.0 1.0 0.0 0 0 0 0 0 GO:0061099 9 negative regulation of protein tyrosine kinase activity 12 12 1 1 1 0 0 0 59 12 2476 0.75438 1.0 1.0 0.0 0 0 0 0 0 GO:0061117 7 negative regulation of heart growth 11 11 1 1 1 0 0 0 59 11 2477 0.77235 1.0 1.0 0.0 0 0 0 0 0 GO:0061136 9 regulation of proteasomal protein catabolic process 49 50 1 1 1 0 0 0 59 50 2438 0.30623 1.0 0.62961 0.0 0 0 0 0 0 GO:0061337 7 cardiac conduction 4 4 1 1 1 0 0 0 59 4 2484 0.91046 1.0 1.0 0.0 0 0 0 0 0 GO:0061515 5 myeloid cell development 17 18 1 1 1 0 0 0 59 18 2470 0.65488 1.0 1.0 0.0 0 0 0 0 0 GO:0061640 5 cytoskeleton-dependent cytokinesis 16 19 1 1 0 1 0 0 59 19 2469 0.63961 1.0 1.0 0.0 0 0 0 0 0 GO:0061771 4 response to caloric restriction 4 4 1 1 1 0 0 0 59 4 2484 0.91046 1.0 1.0 0.0 0 0 0 0 0 GO:0061952 6 midbody abscission 2 2 1 1 0 1 0 0 59 2 2486 0.9542 1.0 1.0 0.0 0 0 0 0 0 GO:0062014 6 negative regulation of small molecule metabolic process 34 38 2 2 2 0 0 0 59 38 2450 0.4077 1.0 1.0 0.0 0 0 0 0 0 GO:0062098 7 regulation of programmed necrotic cell death 10 10 1 1 1 0 0 0 59 10 2478 0.79074 1.0 1.0 0.0 0 0 0 0 0 GO:0062100 8 positive regulation of programmed necrotic cell death 2 2 1 1 1 0 0 0 59 2 2486 0.9542 1.0 1.0 0.0 0 0 0 0 0 GO:0062197 5 cellular response to chemical stress 112 118 2 2 1 1 0 0 59 118 2370 0.0589 1.0 0.11178 0.0 0 0 0 0 0 GO:0065005 7 protein-lipid complex assembly 7 7 1 1 1 0 0 0 59 7 2481 0.84853 1.0 1.0 0.0 0 0 0 0 0 GO:0070167 5 regulation of biomineral tissue development 22 25 2 2 2 0 0 0 59 25 2463 0.55503 1.0 1.0 0.0 0 0 0 0 0 GO:0070168 6 negative regulation of biomineral tissue development 7 9 1 1 1 0 0 0 59 9 2479 0.80956 1.0 1.0 0.0 0 0 0 0 0 GO:0070228 9 regulation of lymphocyte apoptotic process 20 22 1 1 1 0 0 0 59 22 2466 0.59584 1.0 1.0 0.0 0 0 0 0 0 GO:0070232 10 regulation of T cell apoptotic process 11 11 1 1 1 0 0 0 59 11 2477 0.77235 1.0 1.0 0.0 0 0 0 0 0 GO:0070235 8 regulation of activation-induced cell death of T cells 2 2 1 1 1 0 0 0 59 2 2486 0.9542 1.0 1.0 0.0 0 0 0 0 0 GO:0070265 4 necrotic cell death 9 9 1 1 1 0 0 0 59 9 2479 0.80956 1.0 1.0 0.0 0 0 0 0 0 GO:0070266 6 necroptotic process 8 8 1 1 1 0 0 0 59 8 2480 0.82882 1.0 1.0 0.0 0 0 0 0 0 GO:0070301 6 cellular response to hydrogen peroxide 41 45 1 1 1 0 0 0 59 45 2443 0.34508 1.0 0.62513 0.0 0 0 0 0 0 GO:0070328 8 triglyceride homeostasis 18 18 1 1 1 0 0 0 59 18 2470 0.65488 1.0 1.0 0.0 0 0 0 0 0 GO:0070534 11 protein K63-linked ubiquitination 5 5 1 1 0 1 0 0 59 5 2483 0.88934 1.0 1.0 0.0 0 0 0 0 0 GO:0070661 4 leukocyte proliferation 32 36 1 1 1 0 0 0 59 36 2452 0.42756 1.0 1.0 0.0 0 0 0 0 0 GO:0070723 6 response to cholesterol 17 17 1 1 1 0 0 0 59 17 2471 0.67052 1.0 1.0 0.0 0 0 0 0 0 GO:0070848 5 response to growth factor 153 159 3 3 3 0 0 0 59 159 2329 0.02131 1.0 0.049351 0.0 0 0 0 0 0 GO:0070936 11 protein K48-linked ubiquitination 11 11 1 1 0 1 0 0 59 11 2477 0.77235 1.0 1.0 0.0 0 0 0 0 0 GO:0070979 11 protein K11-linked ubiquitination 3 3 1 1 0 1 0 0 59 3 2485 0.93208 1.0 1.0 0.0 0 0 0 0 0 GO:0071277 7 cellular response to calcium ion 24 25 1 1 0 1 0 0 59 25 2463 0.55503 1.0 1.0 0.0 0 0 0 0 0 GO:0071361 6 cellular response to ethanol 11 15 1 1 1 0 0 0 59 15 2473 0.7029 1.0 1.0 0.0 0 0 0 0 0 GO:0071363 6 cellular response to growth factor stimulus 136 141 3 3 3 0 0 0 59 141 2347 0.03337 1.0 0.075207 0.0 0 0 0 0 0 GO:0071374 6 cellular response to parathyroid hormone stimulus 5 6 1 1 1 0 0 0 59 6 2482 0.8687 1.0 1.0 0.0 0 0 0 0 0 GO:0071397 7 cellular response to cholesterol 8 8 1 1 1 0 0 0 59 8 2480 0.82882 1.0 1.0 0.0 0 0 0 0 0 GO:0071478 5 cellular response to radiation 59 61 1 1 1 0 0 0 59 61 2427 0.23528 1.0 0.40142 0.0 0 0 0 0 0 GO:0071479 6 cellular response to ionizing radiation 24 24 1 1 1 0 0 0 59 24 2464 0.56832 1.0 1.0 0.0 0 0 0 0 0 GO:0071480 7 cellular response to gamma radiation 15 15 1 1 1 0 0 0 59 15 2473 0.7029 1.0 1.0 0.0 0 0 0 0 0 GO:0071559 4 response to transforming growth factor beta 37 41 1 1 1 0 0 0 59 41 2447 0.3796 1.0 1.0 0.0 0 0 0 0 0 GO:0071560 6 cellular response to transforming growth factor beta stimulus 33 37 1 1 1 0 0 0 59 37 2451 0.41752 1.0 1.0 0.0 0 0 0 0 0 GO:0071671 6 regulation of smooth muscle cell chemotaxis 3 3 1 1 1 0 0 0 59 3 2485 0.93208 1.0 1.0 0.0 0 0 0 0 0 GO:0071673 7 positive regulation of smooth muscle cell chemotaxis 2 2 1 1 1 0 0 0 59 2 2486 0.9542 1.0 1.0 0.0 0 0 0 0 0 GO:0071694 5 maintenance of protein location in extracellular region 2 2 1 1 1 0 0 0 59 2 2486 0.9542 1.0 1.0 0.0 0 0 0 0 0 GO:0071825 6 protein-lipid complex subunit organization 13 13 1 1 1 0 0 0 59 13 2475 0.73682 1.0 1.0 0.0 0 0 0 0 0 GO:0071827 6 plasma lipoprotein particle organization 13 13 1 1 1 0 0 0 59 13 2475 0.73682 1.0 1.0 0.0 0 0 0 0 0 GO:0071830 4 triglyceride-rich lipoprotein particle clearance 4 4 1 1 1 0 0 0 59 4 2484 0.91046 1.0 1.0 0.0 0 0 0 0 0 GO:0071831 5 intermediate-density lipoprotein particle clearance 1 1 1 1 1 0 0 0 59 1 2487 0.97684 1.0 1.0 0.0 0 0 0 0 0 GO:0071930 8 negative regulation of transcription involved in G1/S transition of mitotic cell cycle 3 3 1 1 1 0 0 0 59 3 2485 0.93208 1.0 1.0 0.0 0 0 0 0 0 GO:0072331 6 signal transduction by p53 class mediator 28 29 2 2 2 0 0 0 59 29 2459 0.50486 1.0 1.0 0.0 0 0 0 0 0 GO:0072332 7 intrinsic apoptotic signaling pathway by p53 class mediator 19 19 1 1 1 0 0 0 59 19 2469 0.63961 1.0 1.0 0.0 0 0 0 0 0 GO:0072337 6 modified amino acid transport 7 8 1 1 1 0 0 0 59 8 2480 0.82882 1.0 1.0 0.0 0 0 0 0 0 GO:0072358 5 cardiovascular system development 2 3 1 1 1 0 0 0 59 3 2485 0.93208 1.0 1.0 0.0 0 0 0 0 0 GO:0072578 6 neurotransmitter-gated ion channel clustering 1 1 1 1 1 0 0 0 59 1 2487 0.97684 1.0 1.0 0.0 0 0 0 0 0 GO:0072593 4 reactive oxygen species metabolic process 40 44 3 3 3 0 0 0 59 44 2444 0.35341 1.0 0.62477 0.0 0 0 0 0 0 GO:0072595 6 maintenance of protein localization in organelle 10 10 1 1 1 0 0 0 59 10 2478 0.79074 1.0 1.0 0.0 0 0 0 0 0 GO:0085020 11 protein K6-linked ubiquitination 2 2 1 1 0 1 0 0 59 2 2486 0.9542 1.0 1.0 0.0 0 0 0 0 0 GO:0090066 4 regulation of anatomical structure size 103 112 2 2 2 0 0 0 59 112 2376 0.068249 1.0 0.11095 0.0 0 0 0 0 0 GO:0090083 6 regulation of inclusion body assembly 9 9 1 1 1 0 0 0 59 9 2479 0.80956 1.0 1.0 0.0 0 0 0 0 0 GO:0090090 8 negative regulation of canonical Wnt signaling pathway 23 23 1 1 1 0 0 0 59 23 2465 0.58192 1.0 1.0 0.0 0 0 0 0 0 GO:0090101 7 negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 24 26 1 1 1 0 0 0 59 26 2462 0.54204 1.0 1.0 0.0 0 0 0 0 0 GO:0090206 7 negative regulation of cholesterol metabolic process 2 2 1 1 1 0 0 0 59 2 2486 0.9542 1.0 1.0 0.0 0 0 0 0 0 GO:0090209 7 negative regulation of triglyceride metabolic process 8 8 1 1 1 0 0 0 59 8 2480 0.82882 1.0 1.0 0.0 0 0 0 0 0 GO:0090261 7 positive regulation of inclusion body assembly 2 2 1 1 1 0 0 0 59 2 2486 0.9542 1.0 1.0 0.0 0 0 0 0 0 GO:0090277 7 positive regulation of peptide hormone secretion 36 38 1 1 1 0 0 0 59 38 2450 0.4077 1.0 1.0 0.0 0 0 0 0 0 GO:0090288 6 negative regulation of cellular response to growth factor stimulus 32 35 1 1 1 0 0 0 59 35 2453 0.43785 1.0 1.0 0.0 0 0 0 0 0 GO:0090329 9 regulation of DNA-dependent DNA replication 14 15 1 1 1 0 0 0 59 15 2473 0.7029 1.0 1.0 0.0 0 0 0 0 0 GO:0090370 9 negative regulation of cholesterol efflux 1 2 1 1 1 0 0 0 59 2 2486 0.9542 1.0 1.0 0.0 0 0 0 0 0 GO:0090420 5 naphthalene-containing compound metabolic process 1 1 1 1 1 0 0 0 59 1 2487 0.97684 1.0 1.0 0.0 0 0 0 0 0 GO:0090596 5 sensory organ morphogenesis 17 17 1 1 1 0 0 0 59 17 2471 0.67052 1.0 1.0 0.0 0 0 0 0 0 GO:0097006 4 regulation of plasma lipoprotein particle levels 2 2 1 1 1 0 0 0 59 2 2486 0.9542 1.0 1.0 0.0 0 0 0 0 0 GO:0097113 8 AMPA glutamate receptor clustering 1 1 1 1 1 0 0 0 59 1 2487 0.97684 1.0 1.0 0.0 0 0 0 0 0 GO:0097114 7 NMDA glutamate receptor clustering 1 1 1 1 1 0 0 0 59 1 2487 0.97684 1.0 1.0 0.0 0 0 0 0 0 GO:0097201 9 negative regulation of transcription from RNA polymerase II promoter in response to stress 8 8 1 1 0 1 0 0 59 8 2480 0.82882 1.0 1.0 0.0 0 0 0 0 0 GO:0097300 5 programmed necrotic cell death 9 9 1 1 1 0 0 0 59 9 2479 0.80956 1.0 1.0 0.0 0 0 0 0 0 GO:0097306 6 cellular response to alcohol 47 52 1 1 1 0 0 0 59 52 2436 0.29193 1.0 0.63248 0.0 0 0 0 0 0 GO:0097527 5 necroptotic signaling pathway 4 6 1 1 1 0 0 0 59 6 2482 0.8687 1.0 1.0 0.0 0 0 0 0 0 GO:0097688 7 glutamate receptor clustering 1 1 1 1 1 0 0 0 59 1 2487 0.97684 1.0 1.0 0.0 0 0 0 0 0 GO:0097746 6 regulation of blood vessel diameter 54 57 2 2 2 0 0 0 59 57 2431 0.25898 1.0 0.64188 0.0 0 0 0 0 0 GO:0097755 7 positive regulation of blood vessel diameter 27 28 2 2 2 0 0 0 59 28 2460 0.51696 1.0 1.0 0.0 0 0 0 0 0 GO:0098801 6 regulation of renal system process 11 12 1 1 1 0 0 0 59 12 2476 0.75438 1.0 1.0 0.0 0 0 0 0 0 GO:0098869 4 cellular oxidant detoxification 38 46 1 1 1 0 0 0 59 46 2442 0.33694 1.0 0.62569 0.0 0 0 0 0 0 GO:0099623 6 regulation of cardiac muscle cell membrane repolarization 3 3 1 1 1 0 0 0 59 3 2485 0.93208 1.0 1.0 0.0 0 0 0 0 0 GO:0106119 9 negative regulation of sterol biosynthetic process 2 2 1 1 1 0 0 0 59 2 2486 0.9542 1.0 1.0 0.0 0 0 0 0 0 GO:0110020 7 regulation of actomyosin structure organization 31 34 1 1 1 0 0 0 59 34 2454 0.44837 1.0 1.0 0.0 0 0 0 0 0 GO:0110053 7 regulation of actin filament organization 56 59 1 1 1 0 0 0 59 59 2429 0.24685 1.0 0.64638 0.0 0 0 0 0 0 GO:0110149 4 regulation of biomineralization 22 25 2 2 2 0 0 0 59 25 2463 0.55503 1.0 1.0 0.0 0 0 0 0 0 GO:0110150 5 negative regulation of biomineralization 7 9 1 1 1 0 0 0 59 9 2479 0.80956 1.0 1.0 0.0 0 0 0 0 0 GO:0120009 6 intermembrane lipid transfer 11 11 1 1 1 0 0 0 59 11 2477 0.77235 1.0 1.0 0.0 0 0 0 0 0 GO:0120161 4 regulation of cold-induced thermogenesis 48 55 1 1 1 0 0 0 59 55 2433 0.2717 1.0 0.63777 0.0 0 0 0 0 0 GO:0120162 5 positive regulation of cold-induced thermogenesis 37 42 1 1 1 0 0 0 59 42 2446 0.37066 1.0 0.62464 0.0 0 0 0 0 0 GO:0120188 7 regulation of bile acid secretion 7 8 1 1 0 1 0 0 59 8 2480 0.82882 1.0 1.0 0.0 0 0 0 0 0 GO:0150200 6 regulation of transport across blood-brain barrier 1 1 1 1 1 0 0 0 59 1 2487 0.97684 1.0 1.0 0.0 0 0 0 0 0 GO:0150201 6 positive regulation of transport across blood-brain barrier 1 1 1 1 1 0 0 0 59 1 2487 0.97684 1.0 1.0 0.0 0 0 0 0 0 GO:0150202 6 negative regulation of transport across blood-brain barrier 1 1 1 1 1 0 0 0 59 1 2487 0.97684 1.0 1.0 0.0 0 0 0 0 0 GO:1900006 9 positive regulation of dendrite development 24 27 1 1 1 0 0 0 59 27 2461 0.52936 1.0 1.0 0.0 0 0 0 0 0 GO:1900046 4 regulation of hemostasis 45 46 1 1 1 0 0 0 59 46 2442 0.33694 1.0 0.62569 0.0 0 0 0 0 0 GO:1900047 5 negative regulation of hemostasis 26 26 1 1 1 0 0 0 59 26 2462 0.54204 1.0 1.0 0.0 0 0 0 0 0 GO:1900115 6 extracellular regulation of signal transduction 2 2 1 1 1 0 0 0 59 2 2486 0.9542 1.0 1.0 0.0 0 0 0 0 0 GO:1900116 7 extracellular negative regulation of signal transduction 2 2 1 1 1 0 0 0 59 2 2486 0.9542 1.0 1.0 0.0 0 0 0 0 0 GO:1900221 5 regulation of amyloid-beta clearance 8 9 1 1 1 0 0 0 59 9 2479 0.80956 1.0 1.0 0.0 0 0 0 0 0 GO:1900223 6 positive regulation of amyloid-beta clearance 2 2 1 1 1 0 0 0 59 2 2486 0.9542 1.0 1.0 0.0 0 0 0 0 0 GO:1900272 7 negative regulation of long-term synaptic potentiation 3 4 1 1 1 0 0 0 59 4 2484 0.91046 1.0 1.0 0.0 0 0 0 0 0 GO:1900542 7 regulation of purine nucleotide metabolic process 30 32 1 1 1 0 0 0 59 32 2456 0.47018 1.0 1.0 0.0 0 0 0 0 0 GO:1900543 8 negative regulation of purine nucleotide metabolic process 8 8 1 1 1 0 0 0 59 8 2480 0.82882 1.0 1.0 0.0 0 0 0 0 0 GO:1901163 5 regulation of trophoblast cell migration 6 6 1 1 1 0 0 0 59 6 2482 0.8687 1.0 1.0 0.0 0 0 0 0 0 GO:1901164 6 negative regulation of trophoblast cell migration 4 4 1 1 1 0 0 0 59 4 2484 0.91046 1.0 1.0 0.0 0 0 0 0 0 GO:1901264 6 carbohydrate derivative transport 18 18 1 1 1 0 0 0 59 18 2470 0.65488 1.0 1.0 0.0 0 0 0 0 0 GO:1901605 7 alpha-amino acid metabolic process 67 72 1 1 1 0 0 0 59 72 2416 0.18055 1.0 0.41245 0.0 0 0 0 0 0 GO:1901626 8 regulation of postsynaptic membrane organization 3 4 1 1 1 0 0 0 59 4 2484 0.91046 1.0 1.0 0.0 0 0 0 0 0 GO:1901627 8 negative regulation of postsynaptic membrane organization 1 1 1 1 1 0 0 0 59 1 2487 0.97684 1.0 1.0 0.0 0 0 0 0 0 GO:1901629 7 regulation of presynaptic membrane organization 1 1 1 1 1 0 0 0 59 1 2487 0.97684 1.0 1.0 0.0 0 0 0 0 0 GO:1901631 7 positive regulation of presynaptic membrane organization 1 1 1 1 1 0 0 0 59 1 2487 0.97684 1.0 1.0 0.0 0 0 0 0 0 GO:1901861 5 regulation of muscle tissue development 56 58 1 1 1 0 0 0 59 58 2430 0.25285 1.0 0.64408 0.0 0 0 0 0 0 GO:1901862 6 negative regulation of muscle tissue development 21 21 1 1 1 0 0 0 59 21 2467 0.61009 1.0 1.0 0.0 0 0 0 0 0 GO:1901863 6 positive regulation of muscle tissue development 31 33 1 1 1 0 0 0 59 33 2455 0.45915 1.0 1.0 0.0 0 0 0 0 0 GO:1901987 7 regulation of cell cycle phase transition 80 85 1 1 1 0 0 0 59 85 2403 0.13184 1.0 0.26379 0.0 0 0 0 0 0 GO:1901988 8 negative regulation of cell cycle phase transition 40 41 1 1 1 0 0 0 59 41 2447 0.3796 1.0 1.0 0.0 0 0 0 0 0 GO:1901990 7 regulation of mitotic cell cycle phase transition 75 79 1 1 1 0 0 0 59 79 2409 0.15246 1.0 0.26068 0.0 0 0 0 0 0 GO:1901991 8 negative regulation of mitotic cell cycle phase transition 37 38 1 1 1 0 0 0 59 38 2450 0.4077 1.0 1.0 0.0 0 0 0 0 0 GO:1902003 7 regulation of amyloid-beta formation 12 13 1 1 1 0 0 0 59 13 2475 0.73682 1.0 1.0 0.0 0 0 0 0 0 GO:1902004 8 positive regulation of amyloid-beta formation 7 8 1 1 1 0 0 0 59 8 2480 0.82882 1.0 1.0 0.0 0 0 0 0 0 GO:1902410 5 mitotic cytokinetic process 4 4 1 1 0 1 0 0 59 4 2484 0.91046 1.0 1.0 0.0 0 0 0 0 0 GO:1902430 8 negative regulation of amyloid-beta formation 6 6 1 1 1 0 0 0 59 6 2482 0.8687 1.0 1.0 0.0 0 0 0 0 0 GO:1902806 8 regulation of cell cycle G1/S phase transition 42 44 1 1 1 0 0 0 59 44 2444 0.35341 1.0 0.62477 0.0 0 0 0 0 0 GO:1902807 9 negative regulation of cell cycle G1/S phase transition 19 19 1 1 1 0 0 0 59 19 2469 0.63961 1.0 1.0 0.0 0 0 0 0 0 GO:1902905 7 positive regulation of supramolecular fiber organization 50 53 1 1 1 0 0 0 59 53 2435 0.28503 1.0 0.63412 0.0 0 0 0 0 0 GO:1902931 7 negative regulation of alcohol biosynthetic process 4 4 1 1 1 0 0 0 59 4 2484 0.91046 1.0 1.0 0.0 0 0 0 0 0 GO:1902947 8 regulation of tau-protein kinase activity 9 10 1 1 1 0 0 0 59 10 2478 0.79074 1.0 1.0 0.0 0 0 0 0 0 GO:1902951 8 negative regulation of dendritic spine maintenance 3 3 1 1 1 0 0 0 59 3 2485 0.93208 1.0 1.0 0.0 0 0 0 0 0 GO:1902991 7 regulation of amyloid precursor protein catabolic process 14 15 1 1 1 0 0 0 59 15 2473 0.7029 1.0 1.0 0.0 0 0 0 0 0 GO:1902992 8 negative regulation of amyloid precursor protein catabolic process 6 6 1 1 1 0 0 0 59 6 2482 0.8687 1.0 1.0 0.0 0 0 0 0 0 GO:1902993 8 positive regulation of amyloid precursor protein catabolic process 8 9 1 1 1 0 0 0 59 9 2479 0.80956 1.0 1.0 0.0 0 0 0 0 0 GO:1902994 8 regulation of phospholipid efflux 2 2 1 1 1 0 0 0 59 2 2486 0.9542 1.0 1.0 0.0 0 0 0 0 0 GO:1902995 8 positive regulation of phospholipid efflux 2 2 1 1 1 0 0 0 59 2 2486 0.9542 1.0 1.0 0.0 0 0 0 0 0 GO:1902996 7 regulation of neurofibrillary tangle assembly 3 3 1 1 1 0 0 0 59 3 2485 0.93208 1.0 1.0 0.0 0 0 0 0 0 GO:1902998 8 positive regulation of neurofibrillary tangle assembly 2 2 1 1 1 0 0 0 59 2 2486 0.9542 1.0 1.0 0.0 0 0 0 0 0 GO:1902999 8 negative regulation of phospholipid efflux 1 1 1 1 1 0 0 0 59 1 2487 0.97684 1.0 1.0 0.0 0 0 0 0 0 GO:1903000 7 regulation of lipid transport across blood-brain barrier 1 1 1 1 1 0 0 0 59 1 2487 0.97684 1.0 1.0 0.0 0 0 0 0 0 GO:1903001 7 negative regulation of lipid transport across blood-brain barrier 1 1 1 1 1 0 0 0 59 1 2487 0.97684 1.0 1.0 0.0 0 0 0 0 0 GO:1903002 7 positive regulation of lipid transport across blood-brain barrier 1 1 1 1 1 0 0 0 59 1 2487 0.97684 1.0 1.0 0.0 0 0 0 0 0 GO:1903035 6 negative regulation of response to wounding 34 36 2 2 2 0 0 0 59 36 2452 0.42756 1.0 1.0 0.0 0 0 0 0 0 GO:1903050 8 regulation of proteolysis involved in cellular protein catabolic process 56 58 1 1 1 0 0 0 59 58 2430 0.25285 1.0 0.64408 0.0 0 0 0 0 0 GO:1903131 6 mononuclear cell differentiation 8 8 1 1 0 1 0 0 59 8 2480 0.82882 1.0 1.0 0.0 0 0 0 0 0 GO:1903224 6 regulation of endodermal cell differentiation 2 2 1 1 1 0 0 0 59 2 2486 0.9542 1.0 1.0 0.0 0 0 0 0 0 GO:1903225 7 negative regulation of endodermal cell differentiation 2 2 1 1 1 0 0 0 59 2 2486 0.9542 1.0 1.0 0.0 0 0 0 0 0 GO:1903362 7 regulation of cellular protein catabolic process 64 67 1 1 1 0 0 0 59 67 2421 0.20367 1.0 0.40499 0.0 0 0 0 0 0 GO:1903364 8 positive regulation of cellular protein catabolic process 44 46 1 1 1 0 0 0 59 46 2442 0.33694 1.0 0.62569 0.0 0 0 0 0 0 GO:1903365 5 regulation of fear response 4 4 2 2 2 0 0 0 59 4 2484 0.91046 1.0 1.0 0.0 0 0 0 0 0 GO:1903367 6 positive regulation of fear response 3 3 1 1 1 0 0 0 59 3 2485 0.93208 1.0 1.0 0.0 0 0 0 0 0 GO:1903524 6 positive regulation of blood circulation 30 32 1 1 1 0 0 0 59 32 2456 0.47018 1.0 1.0 0.0 0 0 0 0 0 GO:1903537 4 meiotic cell cycle process involved in oocyte maturation 2 2 1 1 0 1 0 0 59 2 2486 0.9542 1.0 1.0 0.0 0 0 0 0 0 GO:1903578 5 regulation of ATP metabolic process 33 35 1 1 1 0 0 0 59 35 2453 0.43785 1.0 1.0 0.0 0 0 0 0 0 GO:1903579 6 negative regulation of ATP metabolic process 12 13 1 1 1 0 0 0 59 13 2475 0.73682 1.0 1.0 0.0 0 0 0 0 0 GO:1903845 7 negative regulation of cellular response to transforming growth factor beta stimulus 20 21 1 1 1 0 0 0 59 21 2467 0.61009 1.0 1.0 0.0 0 0 0 0 0 GO:1904421 5 response to D-galactosamine 1 1 1 1 1 0 0 0 59 1 2487 0.97684 1.0 1.0 0.0 0 0 0 0 0 GO:1904486 5 response to 17alpha-ethynylestradiol 6 6 1 1 0 1 0 0 59 6 2482 0.8687 1.0 1.0 0.0 0 0 0 0 0 GO:1904707 8 positive regulation of vascular smooth muscle cell proliferation 18 19 2 2 1 1 0 0 59 19 2469 0.63961 1.0 1.0 0.0 0 0 0 0 0 GO:1905332 6 positive regulation of morphogenesis of an epithelium 13 14 1 1 1 0 0 0 59 14 2474 0.71967 1.0 1.0 0.0 0 0 0 0 0 GO:1905770 6 regulation of mesodermal cell differentiation 1 1 1 1 1 0 0 0 59 1 2487 0.97684 1.0 1.0 0.0 0 0 0 0 0 GO:1905772 7 positive regulation of mesodermal cell differentiation 1 1 1 1 1 0 0 0 59 1 2487 0.97684 1.0 1.0 0.0 0 0 0 0 0 GO:1905809 7 negative regulation of synapse organization 8 8 1 1 1 0 0 0 59 8 2480 0.82882 1.0 1.0 0.0 0 0 0 0 0 GO:1905853 5 regulation of heparan sulfate binding 1 1 1 1 1 0 0 0 59 1 2487 0.97684 1.0 1.0 0.0 0 0 0 0 0 GO:1905855 6 positive regulation of heparan sulfate binding 1 1 1 1 1 0 0 0 59 1 2487 0.97684 1.0 1.0 0.0 0 0 0 0 0 GO:1905858 6 regulation of heparan sulfate proteoglycan binding 1 1 1 1 1 0 0 0 59 1 2487 0.97684 1.0 1.0 0.0 0 0 0 0 0 GO:1905860 7 positive regulation of heparan sulfate proteoglycan binding 1 1 1 1 1 0 0 0 59 1 2487 0.97684 1.0 1.0 0.0 0 0 0 0 0 GO:1905867 5 epididymis development 3 3 1 1 1 0 0 0 59 3 2485 0.93208 1.0 1.0 0.0 0 0 0 0 0 GO:1905890 5 regulation of cellular response to very-low-density lipoprotein particle stimulus 1 1 1 1 1 0 0 0 59 1 2487 0.97684 1.0 1.0 0.0 0 0 0 0 0 GO:1905902 6 regulation of mesoderm formation 1 1 1 1 1 0 0 0 59 1 2487 0.97684 1.0 1.0 0.0 0 0 0 0 0 GO:1905904 7 positive regulation of mesoderm formation 1 1 1 1 1 0 0 0 59 1 2487 0.97684 1.0 1.0 0.0 0 0 0 0 0 GO:1905906 7 regulation of amyloid fibril formation 6 6 1 1 1 0 0 0 59 6 2482 0.8687 1.0 1.0 0.0 0 0 0 0 0 GO:1905907 8 negative regulation of amyloid fibril formation 4 4 1 1 1 0 0 0 59 4 2484 0.91046 1.0 1.0 0.0 0 0 0 0 0 GO:1905953 5 negative regulation of lipid localization 19 22 1 1 1 0 0 0 59 22 2466 0.59584 1.0 1.0 0.0 0 0 0 0 0 GO:1990000 5 amyloid fibril formation 8 8 1 1 1 0 0 0 59 8 2480 0.82882 1.0 1.0 0.0 0 0 0 0 0 GO:1990441 10 negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress 4 4 1 1 0 1 0 0 59 4 2484 0.91046 1.0 1.0 0.0 0 0 0 0 0 GO:1990748 3 cellular detoxification 40 50 1 1 1 0 0 0 59 50 2438 0.30623 1.0 0.62961 0.0 0 0 0 0 0 GO:2000045 8 regulation of G1/S transition of mitotic cell cycle 38 40 1 1 1 0 0 0 59 40 2448 0.38875 1.0 1.0 0.0 0 0 0 0 0 GO:2000105 9 positive regulation of DNA-dependent DNA replication 4 4 1 1 1 0 0 0 59 4 2484 0.91046 1.0 1.0 0.0 0 0 0 0 0 GO:2000106 8 regulation of leukocyte apoptotic process 31 33 1 1 1 0 0 0 59 33 2455 0.45915 1.0 1.0 0.0 0 0 0 0 0 GO:2000134 9 negative regulation of G1/S transition of mitotic cell cycle 18 18 1 1 1 0 0 0 59 18 2470 0.65488 1.0 1.0 0.0 0 0 0 0 0 GO:2000142 8 regulation of DNA-templated transcription, initiation 10 12 1 1 0 1 0 0 59 12 2476 0.75438 1.0 1.0 0.0 0 0 0 0 0 GO:2000144 9 positive regulation of DNA-templated transcription, initiation 9 10 1 1 0 1 0 0 59 10 2478 0.79074 1.0 1.0 0.0 0 0 0 0 0 GO:2000146 6 negative regulation of cell motility 77 82 2 2 2 0 0 0 59 82 2406 0.14179 1.0 0.2616 0.0 0 0 0 0 0 GO:2000171 9 negative regulation of dendrite development 8 8 1 1 1 0 0 0 59 8 2480 0.82882 1.0 1.0 0.0 0 0 0 0 0 GO:2000241 4 regulation of reproductive process 54 57 1 1 1 0 0 0 59 57 2431 0.25898 1.0 0.64188 0.0 0 0 0 0 0 GO:2000242 5 negative regulation of reproductive process 18 21 1 1 1 0 0 0 59 21 2467 0.61009 1.0 1.0 0.0 0 0 0 0 0 GO:2000278 7 regulation of DNA biosynthetic process 42 46 2 2 2 0 0 0 59 46 2442 0.33694 1.0 0.62569 0.0 0 0 0 0 0 GO:2000279 8 negative regulation of DNA biosynthetic process 13 13 1 1 1 0 0 0 59 13 2475 0.73682 1.0 1.0 0.0 0 0 0 0 0 GO:2000380 5 regulation of mesoderm development 1 1 1 1 1 0 0 0 59 1 2487 0.97684 1.0 1.0 0.0 0 0 0 0 0 GO:2000382 6 positive regulation of mesoderm development 1 1 1 1 1 0 0 0 59 1 2487 0.97684 1.0 1.0 0.0 0 0 0 0 0 GO:2000407 7 regulation of T cell extravasation 1 1 1 1 1 0 0 0 59 1 2487 0.97684 1.0 1.0 0.0 0 0 0 0 0 GO:2000449 8 regulation of CD8-positive, alpha-beta T cell extravasation 1 1 1 1 1 0 0 0 59 1 2487 0.97684 1.0 1.0 0.0 0 0 0 0 0 GO:2000452 9 regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation 1 1 1 1 1 0 0 0 59 1 2487 0.97684 1.0 1.0 0.0 0 0 0 0 0 GO:2000542 7 negative regulation of gastrulation 3 3 1 1 1 0 0 0 59 3 2485 0.93208 1.0 1.0 0.0 0 0 0 0 0 GO:2000543 7 positive regulation of gastrulation 2 2 1 1 1 0 0 0 59 2 2486 0.9542 1.0 1.0 0.0 0 0 0 0 0 GO:2000573 8 positive regulation of DNA biosynthetic process 29 33 1 1 1 0 0 0 59 33 2455 0.45915 1.0 1.0 0.0 0 0 0 0 0 GO:2000644 6 regulation of receptor catabolic process 5 5 1 1 1 0 0 0 59 5 2483 0.88934 1.0 1.0 0.0 0 0 0 0 0 GO:2000646 7 positive regulation of receptor catabolic process 3 3 1 1 1 0 0 0 59 3 2485 0.93208 1.0 1.0 0.0 0 0 0 0 0 GO:2000810 7 regulation of bicellular tight junction assembly 6 8 1 1 1 0 0 0 59 8 2480 0.82882 1.0 1.0 0.0 0 0 0 0 0 GO:2000822 5 regulation of behavioral fear response 4 4 2 2 2 0 0 0 59 4 2484 0.91046 1.0 1.0 0.0 0 0 0 0 0 GO:2000987 6 positive regulation of behavioral fear response 3 3 1 1 1 0 0 0 59 3 2485 0.93208 1.0 1.0 0.0 0 0 0 0 0 GO:2001057 4 reactive nitrogen species metabolic process 8 11 1 1 1 0 0 0 59 11 2477 0.77235 1.0 1.0 0.0 0 0 0 0 0 GO:2001138 7 regulation of phospholipid transport 4 4 1 1 1 0 0 0 59 4 2484 0.91046 1.0 1.0 0.0 0 0 0 0 0 GO:2001139 7 negative regulation of phospholipid transport 1 1 1 1 1 0 0 0 59 1 2487 0.97684 1.0 1.0 0.0 0 0 0 0 0 GO:2001140 7 positive regulation of phospholipid transport 4 4 1 1 1 0 0 0 59 4 2484 0.91046 1.0 1.0 0.0 0 0 0 0 0 GO:2001235 7 positive regulation of apoptotic signaling pathway 58 59 1 1 1 0 0 0 59 59 2429 0.24685 1.0 0.64638 0.0 0 0 0 0 0 GO:2001244 8 positive regulation of intrinsic apoptotic signaling pathway 24 24 1 1 1 0 0 0 59 24 2464 0.56832 1.0 1.0 0.0 0 0 0 0 0 GO:0010720 7 positive regulation of cell development 166 176 6 6 6 5 5 5 54 171 2317 0.78032 0.38667 0.59995 2.84 24494;24408;304729;25311;502902 il1b;grin1;gli2;dcc;clec7a IL1B_8892;GRIN1_32381;GLI2_8713;DCC_32537;CLEC7A_32927 279.78319999999997 273.717 153.991 94.22763290670105 286.39421809285477 97.90746817784803 210.09879999999998 183.659 109.464 88.76726219558655 216.45144500056028 92.2714342088552 465.1228 447.21 258.668 226.52586494416042 459.0718580286109 219.19199753643076 153.991;310.025;273.717;248.198;412.985 109.464;254.954;163.744;183.659;338.673 258.668;447.21;831.582;299.409;488.745 3 2 3 24494;24408;502902 IL1B_8892;GRIN1_32381;CLEC7A_32927 292.33366666666666 310.025 130.40019350190138 234.36366666666666 254.954 115.98345912384804 398.2076666666667 447.21 122.6163854724699 153.991;310.025;412.985 109.464;254.954;338.673 258.668;447.21;488.745 2 304729;25311 GLI2_8713;DCC_32537 260.9575 260.9575 18.044657949100255 173.7015 173.7015 14.082031547329832 565.4955 565.4955 376.30313706438864 273.717;248.198 163.744;183.659 831.582;299.409 0 Exp 2,1(0.2);Linear,2(0.4);Poly 2,2(0.4) 2.1790707092513713 11.020082592964172 1.9169143438339233 2.8712503910064697 0.390986660046484 2.0998549461364746 197.1890381249944 362.37736187500553 132.2908640812156 287.9067359187844 266.56412479058497 663.6814752094151 UP 0.6 0.4 0.0 GO:0044087 5 regulation of cellular component biogenesis 211 228 10 10 10 6 6 6 53 222 2266 0.7269 0.43595 0.64713 2.63 366669;313506;25595;24494;24408;502902 syne2;stil;map2;il1b;grin1;clec7a SYNE2_9977;STIL_33274;MAP2_32650;IL1B_8892;GRIN1_32381;CLEC7A_32927 268.47183333333334 293.39099999999996 145.437 102.74817923917996 295.56990401402965 100.74652233632862 191.65516666666667 171.06099999999998 104.718 90.39811211395217 214.5244153936087 94.90063995603319 596.0841666666666 467.97749999999996 237.081 405.2969749274804 634.6018325019486 399.8843947849609 276.757;311.636;145.437;153.991;310.025;412.985 164.88;177.242;104.718;109.464;254.954;338.673 858.911;1285.89;237.081;258.668;447.21;488.745 4 2 4 25595;24494;24408;502902 MAP2_32650;IL1B_8892;GRIN1_32381;CLEC7A_32927 255.6095 232.00799999999998 129.3475859058323 201.95225 182.209 114.76109204887345 357.92600000000004 352.93899999999996 128.50539289072634 145.437;153.991;310.025;412.985 104.718;109.464;254.954;338.673 237.081;258.668;447.21;488.745 2 366669;313506 SYNE2_9977;STIL_33274 294.1965 294.1965 24.663177421006036 171.06099999999998 171.06099999999998 8.741254029028616 1072.4005 1072.4005 301.91974632425126 276.757;311.636 164.88;177.242 858.911;1285.89 0 Exp 2,1(0.17);Linear,4(0.67);Poly 2,1(0.17) 2.031123085346785 12.39672589302063 1.6343638896942139 2.8712503910064697 0.4387128557513657 2.008384644985199 186.25616702890045 350.6874996377662 119.32161219257074 263.9887211407626 271.77904426380127 920.3892890695317 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0061402 9 positive regulation of transcription from RNA polymerase II promoter in response to acidic pH 2 2 1 1 1 1 1 1 58 1 2487 0.99947 0.045801 0.045801 50.0 362282 pck1 PCK1_9439 227.854 227.854 227.854 227.85399999999998 148.568 148.568 148.568 148.568 506.507 506.507 506.507 506.50699999999995 0.0 227.854 0.0 227.854 227.854 148.568 506.507 1 0 1 362282 PCK1_9439 227.854 227.854 148.568 148.568 506.507 506.507 227.854 148.568 506.507 0 0 Exp 2,1(1) 2.162810802459717 2.162810802459717 2.162810802459717 2.162810802459717 0.0 2.162810802459717 227.854 227.854 148.568 148.568 506.507 506.507 UP 1.0 0.0 0.0 GO:0002704 7 negative regulation of leukocyte mediated immunity 17 18 2 2 2 2 2 2 57 16 2472 0.99248 0.063657 0.063657 11.11 294228;24451 rt1-s3;hmox1 RT1-S3_9763;HMOX1_8815 140.2423 140.2423 61.2776 111.67294968872272 164.77974639084508 106.14459544137327 90.6557 90.6557 39.7754 71.95561031761179 106.46621575704224 68.3934575757992 312.67499999999995 312.67499999999995 140.784 243.0905834498738 366.0883125 231.05641704474402 0.0 61.2776 0.5 140.2423 219.207;61.2776 141.536;39.7754 484.566;140.784 1 1 1 24451 HMOX1_8815 61.2776 61.2776 39.7754 39.7754 140.784 140.784 61.2776 39.7754 140.784 1 294228 RT1-S3_9763 219.207 219.207 141.536 141.536 484.566 484.566 219.207 141.536 484.566 0 Linear,1(0.5);Poly 2,1(0.5) 1.6859956628584412 3.377495050430298 1.5923793315887451 1.7851157188415527 0.1362852064078567 1.688747525215149 -14.52851199999995 295.013112 -9.069688000000014 190.381088 -24.231359999999995 649.5813599999999 CONFLICT 0.5 0.5 0.0 GO:0002684 5 positive regulation of immune system process 239 264 11 11 9 10 9 9 50 255 2233 0.92183 0.15106 0.19749 3.41 29142;294228;24494;24451;245920;502902;24232;298566;29650 vnn1;rt1-s3;il1b;hmox1;cxcl10;clec7a;c3;c1qa;adam10 VNN1_10157;RT1-S3_9763;IL1B_8892;HMOX1_8815;CXCL10_8408;CLEC7A_32927;C3_8175;C1QA_8167;ADAM10_7983 239.42473333333334 233.741 61.2776 109.78486981087151 245.42270240454405 110.23396404508833 151.4891111111111 147.819 39.7754 86.86714363325824 158.88249768381192 90.75341749102577 699.6101111111111 488.745 140.784 633.3951668302034 689.477348122436 638.7676239348127 233.741;219.207;153.991;61.2776;344.076;412.985;144.319;268.455;316.771 147.819;141.536;109.464;39.7754;187.725;338.673;57.6936;161.753;178.963 556.851;484.566;258.668;140.784;2052.67;488.745;153.26;786.937;1374.01 6 3 6 29142;24494;24451;502902;24232;298566 VNN1_10157;IL1B_8892;HMOX1_8815;CLEC7A_32927;C3_8175;C1QA_8167 212.4614333333333 193.866 122.24281942955454 142.52966666666666 128.6415 107.4417578415891 397.5408333333333 373.7065 256.98644503974657 233.741;153.991;61.2776;412.985;144.319;268.455 147.819;109.464;39.7754;338.673;57.6936;161.753 556.851;258.668;140.784;488.745;153.26;786.937 3 294228;245920;29650 RT1-S3_9763;CXCL10_8408;ADAM10_7983 293.35133333333334 316.771 65.64622898791167 169.40800000000002 178.963 24.532212476659943 1303.7486666666666 1374.01 786.4095815319985 219.207;344.076;316.771 141.536;187.725;178.963 484.566;2052.67;1374.01 0 Exp 5,1(0.12);Linear,6(0.67);Poly 2,2(0.23) 1.9798892408175344 18.13533067703247 1.5923793315887451 2.8712503910064697 0.41954083347313964 1.929691195487976 167.69861839023062 311.150848276436 94.73591060404908 208.24231161817312 285.7919354487116 1113.4282867735105 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0060284 6 regulation of cell development 252 266 12 12 11 9 9 9 50 257 2231 0.91861 0.15609 0.2008 3.38 338475;25595;24494;24408;304729;84488;25311;502902;29650 nrep;map2;il1b;grin1;gli2;fgf13;dcc;clec7a;adam10 NREP_9364;MAP2_32650;IL1B_8892;GRIN1_32381;GLI2_8713;FGF13_32529;DCC_32537;CLEC7A_32927;ADAM10_7983 254.76777777777775 248.198 145.437 84.80830337115852 268.42199969538365 89.14449239739339 178.55844444444446 163.744 104.718 75.47856112352552 195.30365185123642 84.99809054440648 546.4124444444444 483.266 237.081 357.99021300487783 485.82954429398245 247.70875261544262 222.026;145.437;153.991;310.025;273.717;209.76;248.198;412.985;316.771 142.777;104.718;109.464;254.954;163.744;130.074;183.659;338.673;178.963 497.741;237.081;258.668;447.21;831.582;483.266;299.409;488.745;1374.01 4 5 4 25595;24494;24408;502902 MAP2_32650;IL1B_8892;GRIN1_32381;CLEC7A_32927 255.6095 232.00799999999998 129.3475859058323 201.95225 182.209 114.76109204887345 357.92600000000004 352.93899999999996 128.50539289072634 145.437;153.991;310.025;412.985 104.718;109.464;254.954;338.673 237.081;258.668;447.21;488.745 5 338475;304729;84488;25311;29650 NREP_9364;GLI2_8713;FGF13_32529;DCC_32537;ADAM10_7983 254.0944 248.198 42.843002500992014 159.8434 163.744 23.051224334078178 697.2016 497.741 424.24038784903547 222.026;273.717;209.76;248.198;316.771 142.777;163.744;130.074;183.659;178.963 497.741;831.582;483.266;299.409;1374.01 0 Exp 2,2(0.23);Linear,5(0.56);Poly 2,2(0.23) 1.9657747797389975 17.98795747756958 1.5347857475280762 2.8712503910064697 0.4018413914539392 1.933887243270874 199.35968624195428 310.1758693136013 129.2457845104078 227.87110437848114 312.52550528125767 780.2993836076312 CONFLICT 0.4444444444444444 0.5555555555555556 0.0 GO:0015939 5 pantothenate metabolic process 1 1 1 1 1 1 1 1 58 0 2488 1.0 0.023165 0.023165 100.0 29142 vnn1 VNN1_10157 233.741 233.741 233.741 233.741 147.819 147.819 147.819 147.819 556.851 556.851 556.851 556.851 0.0 233.741 0.0 233.741 233.741 147.819 556.851 1 0 1 29142 VNN1_10157 233.741 233.741 147.819 147.819 556.851 556.851 233.741 147.819 556.851 0 0 Linear,1(1) 1.929691195487976 1.929691195487976 1.929691195487976 1.929691195487976 0.0 1.929691195487976 233.741 233.741 147.819 147.819 556.851 556.851 UP 1.0 0.0 0.0 GO:0071276 7 cellular response to cadmium ion 18 20 3 3 2 3 2 2 57 18 2470 0.98983 0.076772 0.076772 10.0 24567;24451 mt1;hmox1 MT1A_9255;HMOX1_8815 227.0153 227.0153 61.2776 234.3885031365233 226.12862281189814 234.38514886764523 125.5852 125.5852 39.7754 121.35338294452283 125.12612766959128 121.35164628990783 3375.6369999999997 3375.6369999999997 140.784 4574.772984883294 3358.3309171838214 4574.707516575582 0.0 61.2776 1.0 392.753 392.753;61.2776 211.395;39.7754 6610.49;140.784 2 0 2 24567;24451 MT1A_9255;HMOX1_8815 227.0153 227.0153 234.3885031365233 125.5852 125.5852 121.35338294452283 3375.6369999999997 3375.6369999999997 4574.772984883294 392.753;61.2776 211.395;39.7754 6610.49;140.784 0 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.7453413752828657 3.505376100540161 1.5923793315887451 1.912996768951416 0.22671076412579774 1.7526880502700806 -97.83059199999994 551.861192 -42.602008 293.772408 -2964.6748800000005 9715.94888 UP 1.0 0.0 0.0 GO:0051336 5 regulation of hydrolase activity 294 317 8 8 6 5 4 4 55 313 2175 0.12406 0.94798 0.23158 1.26 25595;24408;502902;24232 map2;grin1;clec7a;c3 MAP2_32650;GRIN1_32381;CLEC7A_32927;C3_8175 253.1915 227.731 144.319 131.9447648209912 297.2180461332196 132.49273522916175 189.00965000000002 179.836 57.6936 130.5076790556402 226.7461051983668 136.0251707872163 331.57399999999996 342.14549999999997 153.26 162.06913893150676 372.26444499969534 167.28484839880753 145.437;310.025;412.985;144.319 104.718;254.954;338.673;57.6936 237.081;447.21;488.745;153.26 4 0 4 25595;24408;502902;24232 MAP2_32650;GRIN1_32381;CLEC7A_32927;C3_8175 253.1915 227.731 131.9447648209912 189.00965000000002 179.836 130.5076790556402 331.57399999999996 342.14549999999997 162.06913893150676 145.437;310.025;412.985;144.319 104.718;254.954;338.673;57.6936 237.081;447.21;488.745;153.26 0 0 Exp 2,1(0.25);Exp 5,1(0.25);Linear,1(0.25);Poly 2,1(0.25) 1.9602729588919157 7.86818540096283 1.7257766723632812 2.1256394386291504 0.1857544672929263 2.008384644985199 123.88563047542866 382.49736952457135 61.11212452547257 316.90717547452743 172.7462438471235 490.4017561528765 UP 1.0 0.0 0.0 GO:0071216 4 cellular response to biotic stimulus 97 103 6 6 4 5 4 4 55 99 2389 0.91244 0.21401 0.29908 3.88 24494;24450;245920;502902 il1b;hmgcs2;cxcl10;clec7a IL1B_8892;HMGCS2_8812;CXCL10_8408;CLEC7A_32927 295.127 306.766 153.991 110.85258003613038 314.3200150781927 116.72647206371656 199.499 174.9295 109.464 98.33696117940603 217.386806377668 106.04220252276369 898.8165 641.9639999999999 258.668 800.013862160942 982.5196799449851 898.5148602615991 153.991;269.456;344.076;412.985 109.464;162.134;187.725;338.673 258.668;795.183;2052.67;488.745 3 1 3 24494;24450;502902 IL1B_8892;HMGCS2_8812;CLEC7A_32927 278.8106666666667 269.456 129.7501651264203 203.42366666666666 162.134 120.05339999489121 514.1986666666667 488.745 269.16166734201465 153.991;269.456;412.985 109.464;162.134;338.673 258.668;795.183;488.745 1 245920 CXCL10_8408 344.076 344.076 187.725 187.725 2052.67 2052.67 344.076 187.725 2052.67 0 Linear,3(0.75);Poly 2,1(0.25) 2.308891837863427 9.34952974319458 1.9080781936645508 2.8712503910064697 0.425603806429558 2.28510057926178 186.49147156459236 403.76252843540766 103.12877804418213 295.86922195581786 114.80291508227697 1682.830084917723 UP 0.75 0.25 0.0 GO:0006915 5 apoptotic process 137 149 5 5 5 3 3 3 56 146 2342 0.54316 0.68151 1.0 2.01 25247;84488;25311 nsg1;fgf13;dcc NSG1_32675;FGF13_32529;DCC_32537 224.80999999999997 216.472 209.76 20.53074874426193 226.96809133703363 22.336261959577378 159.99 166.237 130.074 27.333254709236353 158.1821030703295 30.478643037103485 375.08366666666666 342.576 299.409 96.14265653877766 384.2712371249912 105.8376071586624 216.472;209.76;248.198 166.237;130.074;183.659 342.576;483.266;299.409 1 2 1 25247 NSG1_32675 216.472 216.472 166.237 166.237 342.576 342.576 216.472 166.237 342.576 2 84488;25311 FGF13_32529;DCC_32537 228.97899999999998 228.97899999999998 27.17977045524866 156.8665 156.8665 37.89031686988112 391.3375 391.3375 130.00653146861526 209.76;248.198 130.074;183.659 483.266;299.409 0 Exp 2,2(0.67);Poly 2,1(0.34) 2.2281057875853065 7.0352702140808105 1.6639630794525146 3.437419891357422 0.9555642784734669 1.933887243270874 201.57727070423852 248.0427292957615 129.05951055015566 190.92048944984435 266.28800894545964 483.8793243878738 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:1902975 9 mitotic DNA replication initiation 4 4 1 1 1 1 1 1 58 3 2485 0.99693 0.089539 0.089539 25.0 316273 mcm3 MCM3_9207 229.093 229.093 229.093 229.093 133.518 133.518 133.518 133.518 614.889 614.889 614.889 614.889 0.0 229.093 0.0 229.093 229.093 133.518 614.889 0 1 0 1 316273 MCM3_9207 229.093 229.093 133.518 133.518 614.889 614.889 229.093 133.518 614.889 0 Exp 2,1(1) 1.8518693447113037 1.8518693447113037 1.8518693447113037 1.8518693447113037 0.0 1.8518693447113037 229.093 229.093 133.518 133.518 614.889 614.889 DOWN 0.0 1.0 0.0 GO:0051050 5 positive regulation of transport 286 308 11 11 11 8 8 8 51 300 2188 0.72083 0.4225 0.68641 2.6 79212;294228;25595;24494;24408;245920;502902;24232 slc6a1;rt1-s3;map2;il1b;grin1;cxcl10;clec7a;c3 SLC6A1_32594;RT1-S3_9763;MAP2_32650;IL1B_8892;GRIN1_32381;CXCL10_8408;CLEC7A_32927;C3_8175 234.43562500000002 186.599 144.319 107.09074000109506 244.3602459953983 107.2299272207681 162.4357 125.5 57.6936 93.45333478345529 168.42747744494358 92.94021348863123 544.9126249999999 352.93899999999996 153.26 622.7256552438155 601.3320520653008 654.0744776099506 145.445;219.207;145.437;153.991;310.025;344.076;412.985;144.319 104.722;141.536;104.718;109.464;254.954;187.725;338.673;57.6936 237.101;484.566;237.081;258.668;447.21;2052.67;488.745;153.26 6 2 6 79212;25595;24494;24408;502902;24232 SLC6A1_32594;MAP2_32650;IL1B_8892;GRIN1_32381;CLEC7A_32927;C3_8175 218.70033333333333 149.71800000000002 115.36070984987337 161.7041 107.09299999999999 109.59482003187924 303.6775 247.8845 132.9438691128703 145.445;145.437;153.991;310.025;412.985;144.319 104.722;104.718;109.464;254.954;338.673;57.6936 237.101;237.081;258.668;447.21;488.745;153.26 2 294228;245920 RT1-S3_9763;CXCL10_8408 281.6415 281.6415 88.29571665998316 164.63049999999998 164.63049999999998 32.66055511622566 1268.618 1268.618 1108.81697200575 219.207;344.076 141.536;187.725 484.566;2052.67 0 Exp 2,1(0.13);Exp 5,1(0.13);Linear,5(0.63);Poly 2,1(0.13) 2.0972335972949407 16.996662259101868 1.7257766723632812 2.8712503910064697 0.37988196519438894 2.0508097410202026 160.2255283120814 308.6457216879186 97.67584298511967 227.1955570148803 113.38576203109682 976.4394879689032 UP 0.75 0.25 0.0 GO:0006631 6 fatty acid metabolic process 129 145 10 9 9 8 8 8 51 137 2351 0.99467 0.01699 0.01699 5.52 362282;497009;25315;171142;29740;50549;25086;24232 pck1;naaa;ephx1;ehhadh;eci1;cyp4a1;cyp2e1;c3 PCK1_9439;NAAA_32484;EPHX1_8567;EHHADH_8534;ECI1_8520;CYP4A1_33111;CYP2E1_8421;C3_8175 214.3893 211.806 12.5094 118.30060136270295 226.8342950648682 101.60243055273405 124.319825 139.673 3.282 66.48400419834086 132.7618405884815 54.63460487451567 1071.8100749999999 447.254 61.3966 1427.4523826303537 1094.1153025915078 1419.2884599731494 6.5 366.4905 227.854;151.002;12.5094;250.691;195.758;375.605;357.376;144.319 148.568;107.821;3.282;157.555;130.778;197.092;191.769;57.6936 506.507;250.969;61.3966;636.947;388.001;3966.72;2610.68;153.26 8 0 8 362282;497009;25315;171142;29740;50549;25086;24232 PCK1_9439;NAAA_32484;EPHX1_8567;EHHADH_8534;ECI1_8520;CYP4A1_33111;CYP2E1_8421;C3_8175 214.3893 211.806 118.30060136270295 124.319825 139.673 66.48400419834086 1071.8100749999999 447.254 1427.4523826303537 227.854;151.002;12.5094;250.691;195.758;375.605;357.376;144.319 148.568;107.821;3.282;157.555;130.778;197.092;191.769;57.6936 506.507;250.969;61.3966;636.947;388.001;3966.72;2610.68;153.26 0 0 Exp 2,2(0.25);Exp 5,1(0.13);Hill,1(0.13);Linear,4(0.5) 1.8160825847629567 14.66382372379303 1.5261523723602295 2.162810802459717 0.26789086801148176 1.7673457264900208 132.41116570682652 296.36743429317346 78.24876059509994 170.39088940490007 82.63604061275919 2060.984109387241 UP 1.0 0.0 0.0 GO:0071705 5 nitrogen compound transport 239 254 7 7 7 5 5 5 54 249 2239 0.4553 0.71588 0.82875 1.97 79212;29483;84487;25247;311024 slc6a1;slc1a3;slc17a6;nsg1;kif5c SLC6A1_32594;SLC1A3_32817;SLC17A6_32912;NSG1_32675;KIF5C_8965 258.36 256.817 145.445 85.02907397472923 261.55008060137106 99.59453477687552 166.37939999999998 166.237 104.722 39.013298223810835 158.43740120817213 42.8913418099521 479.35119999999995 372.239 237.101 297.1409260102015 434.4353246792914 257.4681802411687 145.445;303.435;369.631;216.472;256.817 104.722;189.179;163.45;166.237;208.309 237.101;992.735;452.105;342.576;372.239 5 0 5 79212;29483;84487;25247;311024 SLC6A1_32594;SLC1A3_32817;SLC17A6_32912;NSG1_32675;KIF5C_8965 258.36 256.817 85.02907397472923 166.37939999999998 166.237 39.013298223810835 479.35119999999995 372.239 297.1409260102015 145.445;303.435;369.631;216.472;256.817 104.722;189.179;163.45;166.237;208.309 237.101;992.735;452.105;342.576;372.239 0 0 Exp 2,3(0.6);Hill,1(0.2);Linear,1(0.2) 2.1923921111454936 11.334226131439209 1.6762725114822388 3.437419891357422 0.6991288751862139 2.0017645359039307 183.8287305272296 332.89126947277043 132.1827363528742 200.5760636471258 218.8956946932301 739.80670530677 UP 1.0 0.0 0.0 GO:0050770 8 regulation of axonogenesis 44 46 4 4 4 3 3 3 56 43 2445 0.97946 0.088879 0.088879 6.52 25595;24408;84488 map2;grin1;fgf13 MAP2_32650;GRIN1_32381;FGF13_32529 221.74066666666667 209.76 145.437 82.94549244132148 242.29838384635627 68.57392045026917 163.24866666666668 130.074 104.718 80.42470270590582 175.41703709550123 76.8913348014177 389.1856666666667 447.21 237.081 132.95443204471718 447.87611847759365 82.82900192776549 1.5 259.8925 145.437;310.025;209.76 104.718;254.954;130.074 237.081;447.21;483.266 2 1 2 25595;24408 MAP2_32650;GRIN1_32381 227.731 227.731 116.38129090193146 179.836 179.836 106.23289437834215 342.14549999999997 342.14549999999997 148.58364082394812 145.437;310.025 104.718;254.954 237.081;447.21 1 84488 FGF13_32529 209.76 209.76 130.074 130.074 483.266 483.266 209.76 130.074 483.266 0 Exp 2,2(0.67);Linear,1(0.34) 1.8926864112233497 5.706516861915588 1.6639630794525146 2.1256394386291504 0.2311909629044151 1.9169143438339233 127.87900598410305 315.6023273492303 72.23954810343601 254.25778522989737 238.73356348996285 539.6377698433704 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0010468 6 regulation of gene expression 723 775 22 22 18 17 14 14 45 761 1727 0.1615 0.90119 0.31641 1.81 360243;311715;78968;294228;291773;362282;681410;24494;24451;24408;304729;316098;502902;24232 top2a;tcfl5;srebf1;rt1-s3;taf4b;pck1;loc681410;il1b;hmox1;grin1;gli2;exosc7;clec7a;c3 TOP2A_10059;TCFL5_9994;SREBF1_32750;RT1-S3_9763;RGD1562997_32695;PCK1_9439;LOC681410_33126;IL1B_8892;HMOX1_8815;GRIN1_32381;GLI2_8713;EXOSC7_8580;CLEC7A_32927;C3_8175 232.73061428571432 223.53050000000002 61.2776 102.85016518347192 234.23641651704315 105.61271643056195 161.1692857142857 145.05200000000002 39.7754 94.84543659837678 164.29722373022625 97.5695840290444 452.0397142857143 465.888 140.784 216.5134976820786 434.99193922450456 205.6608998326462 203.468;270.921;177.986;219.207;279.902;227.854;410.591;153.991;61.2776;310.025;273.717;111.985;412.985;144.319 108.442;228.673;117.256;141.536;166.045;148.568;326.66;109.464;39.7754;254.954;163.744;54.886;338.673;57.6936 572.253;338.867;348.781;484.566;888.462;506.507;495.344;258.668;140.784;447.21;831.582;373.527;488.745;153.26 9 5 9 311715;362282;681410;24494;24451;24408;316098;502902;24232 TCFL5_9994;PCK1_9439;LOC681410_33126;IL1B_8892;HMOX1_8815;GRIN1_32381;EXOSC7_8580;CLEC7A_32927;C3_8175 233.7720666666667 227.854 127.26207586822555 173.2607777777778 148.568 117.52834252355657 355.8791111111111 373.527 143.83374207782776 270.921;227.854;410.591;153.991;61.2776;310.025;111.985;412.985;144.319 228.673;148.568;326.66;109.464;39.7754;254.954;54.886;338.673;57.6936 338.867;506.507;495.344;258.668;140.784;447.21;373.527;488.745;153.26 5 360243;78968;294228;291773;304729 TOP2A_10059;SREBF1_32750;RT1-S3_9763;RGD1562997_32695;GLI2_8713 230.856 219.207 44.5073423212395 139.4046 141.536 26.248348763303245 625.1288 572.253 229.6133464907913 203.468;177.986;219.207;279.902;273.717 108.442;117.256;141.536;166.045;163.744 572.253;348.781;484.566;888.462;831.582 0 Exp 2,5(0.36);Exp 5,1(0.08);Linear,4(0.29);Poly 2,4(0.29) 1.915970027660161 27.162678480148315 1.5889767408370972 2.8712503910064697 0.3381773328809693 1.8807859420776367 178.85440304516214 286.6068255262664 111.48620773126949 210.85236369730194 338.6230083743367 565.456420197092 UP 0.6428571428571429 0.35714285714285715 0.0 GO:1901652 5 response to peptide 225 236 8 8 8 5 5 5 54 231 2257 0.52995 0.6512 1.0 2.12 78968;362282;24494;24450;24408 srebf1;pck1;il1b;hmgcs2;grin1 SREBF1_32750;PCK1_9439;IL1B_8892;HMGCS2_8812;GRIN1_32381 227.86239999999998 227.854 153.991 64.0807293287149 217.1926473560729 71.54401561286721 158.4752 148.568 109.464 58.139527115380005 157.32055970643086 67.25363866749046 471.26980000000003 447.21 258.668 204.29349406111783 398.10759658304755 162.42023633644868 177.986;227.854;153.991;269.456;310.025 117.256;148.568;109.464;162.134;254.954 348.781;506.507;258.668;795.183;447.21 4 1 4 362282;24494;24450;24408 PCK1_9439;IL1B_8892;HMGCS2_8812;GRIN1_32381 240.3315 248.65500000000003 66.62279487032441 168.78000000000003 155.351 61.63613764667595 501.892 476.8585 222.25281715949833 227.854;153.991;269.456;310.025 148.568;109.464;162.134;254.954 506.507;258.668;795.183;447.21 1 78968 SREBF1_32750 177.986 177.986 117.256 117.256 348.781 348.781 177.986 117.256 348.781 0 Exp 2,3(0.6);Linear,2(0.4) 2.0487133742865855 10.448030471801758 1.5889767408370972 2.8712503910064697 0.48211287703382705 1.9169143438339233 171.69316420390595 284.03163579609406 107.51365755460472 209.43674244539528 292.19865708800927 650.3409429119909 UP 0.8 0.2 0.0 GO:0048646 3 anatomical structure formation involved in morphogenesis 166 174 5 5 4 4 3 3 56 171 2317 0.41815 0.78001 0.79534 1.72 313506;24451;304729 stil;hmox1;gli2 STIL_33274;HMOX1_8815;GLI2_8713 215.54353333333333 273.717 61.2776 134.9368232939154 217.402705974494 134.22875735048808 126.92046666666666 163.744 39.7754 75.77101018366676 127.95534122539506 75.3502810178925 752.7520000000001 831.582 140.784 576.6086753457668 760.7170180205156 574.9242373641212 311.636;61.2776;273.717 177.242;39.7754;163.744 1285.89;140.784;831.582 1 2 1 24451 HMOX1_8815 61.2776 61.2776 39.7754 39.7754 140.784 140.784 61.2776 39.7754 140.784 2 313506;304729 STIL_33274;GLI2_8713 292.67650000000003 292.67650000000003 26.812782035812145 170.493 170.493 9.544527332455957 1058.736 1058.736 321.2442675472976 311.636;273.717 177.242;163.744 1285.89;831.582 0 Linear,2(0.67);Poly 2,1(0.34) 1.788487444008585 5.42491888999939 1.5923793315887451 2.1981756687164307 0.33828873943246296 1.6343638896942139 62.84814327875674 368.23892338790995 41.177496939099285 212.66343639423403 100.25785910121385 1405.246140898786 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0000819 5 sister chromatid segregation 14 14 2 2 2 2 2 2 57 12 2476 0.99642 0.040155 0.040155 14.29 360243;500545 top2a;cdca8 TOP2A_10059;CDCA8_33310 328.683 328.683 203.468 177.08075121254717 373.95736741573035 165.10013858325783 166.331 166.331 108.442 81.86740891221612 187.26210134831462 76.32857023875889 523.523 523.523 474.793 68.91462689444103 505.9035460674157 64.25212437137918 0.0 203.468 0.5 328.683 203.468;453.898 108.442;224.22 572.253;474.793 0 2 0 2 360243;500545 TOP2A_10059;CDCA8_33310 328.683 328.683 177.08075121254717 166.331 166.331 81.86740891221612 523.523 523.523 68.91462689444103 203.468;453.898 108.442;224.22 572.253;474.793 0 Exp 2,1(0.5);Power,1(0.5) 2.033539176560457 4.068149566650391 1.9873988628387451 2.0807507038116455 0.06600971978818605 2.0340747833251953 83.26159999999999 574.1043999999999 52.86855999999999 279.79344 428.0122 619.0338 DOWN 0.0 1.0 0.0 GO:0035176 3 social behavior 6 6 2 2 2 2 2 2 57 4 2484 0.99978 0.0074544 0.0074544 33.33 24494;24408 il1b;grin1 IL1B_8892;GRIN1_32381 232.00799999999998 232.00799999999998 153.991 110.3326994956618 226.9445783015822 110.10008219528241 182.209 182.209 109.464 102.8769655948308 177.4877391023571 102.66006741217737 352.93899999999996 352.93899999999996 258.668 133.31932673847408 346.82066903454955 133.03824613393877 0.0 153.991 0.0 153.991 153.991;310.025 109.464;254.954 258.668;447.21 2 0 2 24494;24408 IL1B_8892;GRIN1_32381 232.00799999999998 232.00799999999998 110.3326994956618 182.209 182.209 102.8769655948308 352.93899999999996 352.93899999999996 133.31932673847408 153.991;310.025 109.464;254.954 258.668;447.21 0 0 Exp 2,1(0.5);Linear,1(0.5) 2.3460479661036477 4.788164734840393 1.9169143438339233 2.8712503910064697 0.6748174904864724 2.3940823674201965 79.09468000000004 384.9213199999999 39.62880000000001 324.7892 168.16784 537.7101599999999 UP 1.0 0.0 0.0 GO:0006732 5 coenzyme metabolic process 61 67 3 2 2 2 2 2 57 65 2423 0.79868 0.46391 0.66758 2.99 29142;24450 vnn1;hmgcs2 VNN1_10157;HMGCS2_8812 251.5985 251.5985 233.741 25.254318690077955 246.46191900311527 24.1870147770432 154.9765 154.9765 147.819 10.122233572685554 152.91769678089304 9.694445374026726 676.017 676.017 556.851 168.526173373752 641.7397601246106 161.40388088596217 233.741;269.456 147.819;162.134 556.851;795.183 2 0 2 29142;24450 VNN1_10157;HMGCS2_8812 251.5985 251.5985 25.254318690077955 154.9765 154.9765 10.122233572685554 676.017 676.017 168.526173373752 233.741;269.456 147.819;162.134 556.851;795.183 0 0 Linear,2(1) 1.918854265080359 3.837769389152527 1.9080781936645508 1.929691195487976 0.015282700151141242 1.9188846945762634 216.5978 286.5992 140.9478 169.00519999999997 442.45164000000005 909.5823600000001 UP 1.0 0.0 0.0 GO:0051094 5 positive regulation of developmental process 376 396 12 12 10 9 8 8 51 388 2100 0.41842 0.71962 0.85554 2.02 29142;24494;24451;24408;304729;25311;502902;24232 vnn1;il1b;hmox1;grin1;gli2;dcc;clec7a;c3 VNN1_10157;IL1B_8892;HMOX1_8815;GRIN1_32381;GLI2_8713;DCC_32537;CLEC7A_32927;C3_8175 229.7817 240.9695 61.2776 109.36787076431546 239.09500179362846 116.22927540487944 161.97275 155.7815 39.7754 99.35919894476665 172.13530896814223 105.90289449842359 397.063625 373.30949999999996 140.784 232.70692341160898 391.2753894102925 229.28934005405674 233.741;153.991;61.2776;310.025;273.717;248.198;412.985;144.319 147.819;109.464;39.7754;254.954;163.744;183.659;338.673;57.6936 556.851;258.668;140.784;447.21;831.582;299.409;488.745;153.26 6 2 6 29142;24494;24451;24408;502902;24232 VNN1_10157;IL1B_8892;HMOX1_8815;GRIN1_32381;CLEC7A_32927;C3_8175 219.38976666666667 193.866 127.13134446424559 158.06316666666666 128.6415 117.0816920683617 340.91966666666667 352.93899999999996 179.8955680862279 233.741;153.991;61.2776;310.025;412.985;144.319 147.819;109.464;39.7754;254.954;338.673;57.6936 556.851;258.668;140.784;447.21;488.745;153.26 2 304729;25311 GLI2_8713;DCC_32537 260.9575 260.9575 18.044657949100255 173.7015 173.7015 14.082031547329832 565.4955 565.4955 376.30313706438864 273.717;248.198 163.744;183.659 831.582;299.409 0 Exp 2,1(0.13);Exp 5,1(0.13);Linear,3(0.38);Poly 2,3(0.38) 2.0044002331095854 16.267929792404175 1.5923793315887451 2.8712503910064697 0.3885723037427814 1.931789219379425 153.99363219984625 305.5697678001537 93.12033791983441 230.82516208016557 235.8059542980609 558.321295701939 UP 0.75 0.25 0.0 GO:0032526 5 response to retinoic acid 42 45 5 5 5 3 3 3 56 42 2446 0.98092 0.084422 0.084422 6.67 78968;362282;58827 srebf1;pck1;mest SREBF1_32750;PCK1_9439;MEST_9219 226.02266666666665 227.854 177.986 47.14768262951372 214.18808380681816 50.88714361625429 154.8886666666667 148.568 117.256 41.158619623759606 146.58760984848485 43.57848735633211 466.192 506.507 348.781 103.33062315209374 432.7818667140151 111.57909745181155 1.5 250.041 177.986;227.854;272.228 117.256;148.568;198.842 348.781;506.507;543.288 2 1 2 362282;58827 PCK1_9439;MEST_9219 250.041 250.041 31.37715630837219 173.705 173.705 35.549086317372506 524.8975 524.8975 26.00809451882127 227.854;272.228 148.568;198.842 506.507;543.288 1 78968 SREBF1_32750 177.986 177.986 117.256 117.256 348.781 348.781 177.986 117.256 348.781 0 Exp 2,3(1) 1.9568605449511038 5.932224631309509 1.5889767408370972 2.1804370880126953 0.3365069485418755 2.162810802459717 172.67004124134596 279.3752920919874 108.3133040329346 201.46402930039875 349.2623923389096 583.1216076610904 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0071902 9 positive regulation of protein serine/threonine kinase activity 93 101 4 4 3 2 2 2 57 99 2389 0.58282 0.68777 1.0 1.98 313506;24494 stil;il1b STIL_33274;IL1B_8892 232.81350000000003 232.81350000000003 153.991 111.47184852015332 232.38093750000002 111.47016996428779 143.353 143.353 109.464 47.92628341526173 143.16702378048782 47.92556173579553 772.279 772.279 258.668 726.3556419840078 769.4604030487806 726.3447044375371 311.636;153.991 177.242;109.464 1285.89;258.668 1 1 1 24494 IL1B_8892 153.991 153.991 109.464 109.464 258.668 258.668 153.991 109.464 258.668 1 313506 STIL_33274 311.636 311.636 177.242 177.242 1285.89 1285.89 311.636 177.242 1285.89 0 Linear,2(1) 2.166256669310303 4.505614280700684 1.6343638896942139 2.8712503910064697 0.8746108326359996 2.252807140350342 78.32140000000004 387.3056 76.93056000000001 209.77544 -234.39855999999997 1778.95656 CONFLICT 0.5 0.5 0.0 GO:0071496 4 cellular response to external stimulus 143 149 6 6 5 5 4 4 55 145 2343 0.73916 0.45684 0.77533 2.68 78968;362282;24494;24451 srebf1;pck1;il1b;hmox1 SREBF1_32750;PCK1_9439;IL1B_8892;HMOX1_8815 155.27715 165.9885 61.2776 69.81084110239135 139.81629668695933 63.81535275694381 103.76585 113.36 39.7754 45.88559467585298 94.33107780839474 43.06466304753074 313.685 303.72450000000003 140.784 154.20082035017415 272.05860262736303 126.45846367648254 177.986;227.854;153.991;61.2776 117.256;148.568;109.464;39.7754 348.781;506.507;258.668;140.784 3 1 3 362282;24494;24451 PCK1_9439;IL1B_8892;HMOX1_8815 147.70753333333334 153.991 83.46577576619852 99.26913333333334 109.464 55.10815668713058 301.98633333333333 258.668 186.66999406528447 227.854;153.991;61.2776 148.568;109.464;39.7754 506.507;258.668;140.784 1 78968 SREBF1_32750 177.986 177.986 117.256 117.256 348.781 348.781 177.986 117.256 348.781 0 Exp 2,2(0.5);Linear,1(0.25);Poly 2,1(0.25) 1.9909640461188547 8.215417265892029 1.5889767408370972 2.8712503910064697 0.6080236235828169 1.877595067024231 86.86252571965647 223.69177428034354 58.79796721766408 148.73373278233592 162.56819605682938 464.8018039431706 UP 0.75 0.25 0.0 GO:0031175 7 neuron projection development 77 81 5 5 4 4 3 3 56 78 2410 0.88411 0.28881 0.43407 3.7 338475;288280;25595 nrep;ncam2;map2 NREP_9364;NCAM2_32618;MAP2_32650 227.29866666666666 222.026 145.437 84.62129025448237 285.9275616075072 68.69172436832747 169.77366666666668 142.777 104.718 81.9594163249918 231.3029855161159 70.50320010330012 383.43833333333333 415.493 237.081 133.253649636073 407.22371032231746 77.54845913313557 222.026;314.433;145.437 142.777;261.826;104.718 497.741;415.493;237.081 2 1 2 288280;25595 NCAM2_32618;MAP2_32650 229.935 229.935 119.49821759340176 183.27200000000002 183.27200000000002 111.09213217865612 326.287 326.287 126.15633504505426 314.433;145.437 261.826;104.718 415.493;237.081 1 338475 NREP_9364 222.026 222.026 142.777 142.777 497.741 497.741 222.026 142.777 497.741 0 Exp 2,1(0.34);Linear,2(0.67) 1.7803945644954813 5.3902870416641235 1.5347857475280762 2.1256394386291504 0.3010544434411658 1.729861855506897 131.54066223977304 323.05667109356034 77.02785615406373 262.5194771792696 232.64763357707497 534.2290330895916 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0060627 5 regulation of vesicle-mediated transport 135 149 6 6 6 4 4 4 55 145 2343 0.73916 0.45684 0.77533 2.68 24494;24451;502902;24232 il1b;hmox1;clec7a;c3 IL1B_8892;HMOX1_8815;CLEC7A_32927;C3_8175 193.14315 149.155 61.2776 152.35446690866448 214.13554111170137 162.934920659816 136.4015 83.5788 39.7754 138.047003278014 156.30017614333318 147.70854344963232 260.36424999999997 205.964 140.784 161.17423366525853 283.43307205292894 170.9467730447588 153.991;61.2776;412.985;144.319 109.464;39.7754;338.673;57.6936 258.668;140.784;488.745;153.26 4 0 4 24494;24451;502902;24232 IL1B_8892;HMOX1_8815;CLEC7A_32927;C3_8175 193.14315 149.155 152.35446690866448 136.4015 83.5788 138.047003278014 260.36424999999997 205.964 161.17423366525853 153.991;61.2776;412.985;144.319 109.464;39.7754;338.673;57.6936 258.668;140.784;488.745;153.26 0 0 Exp 5,1(0.25);Linear,1(0.25);Poly 2,2(0.5) 2.017543337515886 8.28926134109497 1.5923793315887451 2.8712503910064697 0.5743063253380907 1.912815809249878 43.835772429508836 342.45052757049115 1.1154367875462867 271.6875632124537 102.41350100804672 418.3149989919533 UP 1.0 0.0 0.0 GO:0016999 5 antibiotic metabolic process 46 51 2 2 2 2 2 2 57 49 2439 0.88741 0.33198 0.33198 3.92 362282;50549 pck1;cyp4a1 PCK1_9439;CYP4A1_33111 301.72950000000003 301.72950000000003 227.854 104.47573402709348 336.2981249302845 92.33200605076561 172.83 172.83 148.568 34.31164945029603 184.18293809258225 30.323437821790527 2236.6135 2236.6135 506.507 2446.7400766498467 3046.1836915783597 2162.343453871298 227.854;375.605 148.568;197.092 506.507;3966.72 2 0 2 362282;50549 PCK1_9439;CYP4A1_33111 301.72950000000003 301.72950000000003 104.47573402709348 172.83 172.83 34.31164945029603 2236.6135 2236.6135 2446.7400766498467 227.854;375.605 148.568;197.092 506.507;3966.72 0 0 Exp 2,1(0.5);Linear,1(0.5) 1.84916962670435 3.7438220977783203 1.5810112953186035 2.162810802459717 0.41139437679047236 1.8719110488891602 156.93352000000004 446.52548 125.27648000000002 220.38352 -1154.3952399999998 5627.62224 UP 1.0 0.0 0.0 GO:0035295 4 tube development 61 65 4 4 4 3 3 3 56 62 2426 0.9383 0.18938 0.18938 4.62 313506;24450;304729 stil;hmgcs2;gli2 STIL_33274;HMGCS2_8812;GLI2_8713 284.9363333333333 273.717 269.456 23.220533592778867 289.90251387137454 23.684766901944457 167.70666666666668 163.744 162.134 8.296985074912696 169.494026481715 8.446037282104989 970.8849999999999 831.582 795.183 273.40873124134197 1027.3115636822195 281.47493921709406 311.636;269.456;273.717 177.242;162.134;163.744 1285.89;795.183;831.582 1 2 1 24450 HMGCS2_8812 269.456 269.456 162.134 162.134 795.183 795.183 269.456 162.134 795.183 2 313506;304729 STIL_33274;GLI2_8713 292.67650000000003 292.67650000000003 26.812782035812145 170.493 170.493 9.544527332455957 1058.736 1058.736 321.2442675472976 311.636;273.717 177.242;163.744 1285.89;831.582 0 Linear,3(1) 1.8996303851862628 5.740617752075195 1.6343638896942139 2.1981756687164307 0.28194555839548147 1.9080781936645508 258.65982594511974 311.212840721547 158.31774419639822 177.09558913693508 661.4938950212744 1280.276104978726 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0006935 4 chemotaxis 73 79 5 5 4 4 4 4 55 75 2413 0.96578 0.10822 0.10822 5.06 361680;24494;245920;24232 lsp1;il1b;cxcl10;c3 LSP1_32853;IL1B_8892;CXCL10_8408;C3_8175 218.48025 192.763 144.319 92.38230942258372 230.5082938186588 103.69777926958733 124.09615 125.483 57.6936 54.696107803846516 129.47111549434334 58.89971099679291 761.37575 419.7865 153.26 879.8731687004193 926.2513218560421 993.9473341404062 2.5 287.8055 231.535;153.991;344.076;144.319 141.502;109.464;187.725;57.6936 580.905;258.668;2052.67;153.26 2 2 2 24494;24232 IL1B_8892;C3_8175 149.155 149.155 6.839136787636285 83.5788 83.5788 36.607200904740054 205.964 205.964 74.5347115913116 153.991;144.319 109.464;57.6936 258.668;153.26 2 361680;245920 LSP1_32853;CXCL10_8408 287.8055 287.8055 79.57850426151533 164.6135 164.6135 32.68459674678586 1316.7875 1316.7875 1040.6950118130196 231.535;344.076 141.502;187.725 580.905;2052.67 0 Exp 2,1(0.25);Exp 5,1(0.25);Linear,2(0.5) 2.1456894965952324 8.798998951911926 1.7257766723632812 2.8712503910064697 0.568015898593834 2.1009859442710876 127.94558676586796 309.01491323413205 70.4939643522304 177.69833564776957 -100.89995532641103 1623.6514553264115 CONFLICT 0.5 0.5 0.0 GO:1901135 4 carbohydrate derivative metabolic process 159 175 4 3 3 3 3 3 56 172 2316 0.41348 0.78339 0.7954 1.71 303872;24494;24450 pigz;il1b;hmgcs2 PIGZ_32744;IL1B_8892;HMGCS2_8812 259.51466666666664 269.456 153.991 100.92090165239978 263.50615323178266 115.62976013949492 161.35933333333332 162.134 109.464 51.51236885771549 164.83118452037874 59.22778099321662 504.48033333333336 459.59 258.668 271.0598510040417 415.66019036640597 202.12615876105394 355.097;153.991;269.456 212.48;109.464;162.134 459.59;258.668;795.183 3 0 3 303872;24494;24450 PIGZ_32744;IL1B_8892;HMGCS2_8812 259.51466666666664 269.456 100.92090165239978 161.35933333333332 162.134 51.51236885771549 504.48033333333336 459.59 271.0598510040417 355.097;153.991;269.456 212.48;109.464;162.134 459.59;258.668;795.183 0 0 Linear,2(0.67);Poly 2,1(0.34) 2.162273316536721 6.624618172645569 1.8452895879745483 2.8712503910064697 0.5750708159428223 1.9080781936645508 145.31191558435614 373.71741774897714 103.06760048120259 219.65106618546406 197.74723656371395 811.2134301029527 UP 1.0 0.0 0.0 GO:0098609 4 cell-cell adhesion 84 86 3 3 3 3 3 3 56 83 2405 0.8639 0.32099 0.44967 3.49 29142;24494;29182 vnn1;il1b;cdh22 VNN1_10157;IL1B_8892;CDH22_32502 231.59800000000004 233.741 153.991 76.55799825622395 213.50966716477384 78.64595130191618 157.99133333333336 147.819 109.464 54.332445705428405 146.8310150428372 54.19168611671224 524.4246666666667 556.851 258.668 251.11861482640705 462.155746264196 260.8170069436576 233.741;153.991;307.062 147.819;109.464;216.691 556.851;258.668;757.755 3 0 3 29142;24494;29182 VNN1_10157;IL1B_8892;CDH22_32502 231.59800000000004 233.741 76.55799825622395 157.99133333333336 147.819 54.332445705428405 524.4246666666667 556.851 251.11861482640705 233.741;153.991;307.062 147.819;109.464;216.691 556.851;258.668;757.755 0 0 Exp 2,1(0.34);Linear,2(0.67) 2.1133284492913242 6.504441499710083 1.7034999132156372 2.8712503910064697 0.6193191682837635 1.929691195487976 144.96446943237436 318.23153056762567 96.50838311196401 219.47428355470265 240.25720292430475 808.5921304090286 UP 1.0 0.0 0.0 GO:0007268 7 chemical synaptic transmission 38 38 4 4 3 4 3 3 56 35 2453 0.98934 0.056163 0.056163 7.89 84487;25247;24408 slc17a6;nsg1;grin1 SLC17A6_32912;NSG1_32675;GRIN1_32381 298.7093333333333 310.025 216.472 77.20397045705188 331.46589512242144 65.17750780737633 194.88033333333337 166.237 163.45 52.043980558113724 189.3859003277424 49.98726349924273 413.9636666666667 447.21 342.576 61.8719602916646 435.3449072681705 46.01903927383336 0.5 263.2485 369.631;216.472;310.025 163.45;166.237;254.954 452.105;342.576;447.21 3 0 3 84487;25247;24408 SLC17A6_32912;NSG1_32675;GRIN1_32381 298.7093333333333 310.025 77.20397045705188 194.88033333333337 166.237 52.043980558113724 413.9636666666667 447.21 61.8719602916646 369.631;216.472;310.025 163.45;166.237;254.954 452.105;342.576;447.21 0 0 Exp 2,2(0.67);Hill,1(0.34) 2.309015982293717 7.222629547119141 1.8682953119277954 3.437419891357422 0.8922306200457578 1.9169143438339233 211.34481640659519 386.07385026007137 135.98702521087702 253.77364145578966 343.9489525244891 483.97838080884424 UP 1.0 0.0 0.0 GO:0032502 2 developmental process 992 1073 42 41 39 30 29 29 30 1044 1444 0.89185 0.16538 0.2874 2.7 246118;365377;360243;311715;313506;78968;29483;84487;294228;362282;338475;24584;25595;24503;24494;24451;24450;24408;304729;84488;80841;25315;25311;50549;25279;29182;24232;298566;29650 tubb3;trim72;top2a;tcfl5;stil;srebf1;slc1a3;slc17a6;rt1-s3;pck1;nrep;mylpf;map2;ina;il1b;hmox1;hmgcs2;grin1;gli2;fgf13;fabp7;ephx1;dcc;cyp4a1;cyp24a1;cdh22;c3;c1qa;adam10 TUBB3_32820;TRIM72_33144;TOP2A_10059;TCFL5_9994;STIL_33274;SREBF1_32750;SLC1A3_32817;SLC17A6_32912;RT1-S3_9763;PCK1_9439;NREP_9364;MYLPF_32295;MAP2_32650;INA_32322;IL1B_8892;HMOX1_8815;HMGCS2_8812;GRIN1_32381;GLI2_8713;FGF13_32529;FABP7_8592;EPHX1_8567;DCC_32537;CYP4A1_33111;CYP24A1_32574;CDH22_32502;C3_8175;C1QA_8167;ADAM10_7983 235.96809655172416 248.198 12.5094 89.79664990726262 239.32659501106355 85.89850267007557 153.1302275862069 162.134 3.282 62.82781010143574 154.9827339478903 60.21302113360986 687.4248137931036 459.059 61.3966 773.9994895742723 624.2802059383349 711.7056036048806 282.273;82.0928;203.468;270.921;311.636;177.986;303.435;369.631;219.207;227.854;222.026;353.211;145.437;305.642;153.991;61.2776;269.456;310.025;273.717;209.76;227.998;12.5094;248.198;375.605;189.111;307.062;144.319;268.455;316.771 238.208;49.3056;108.442;228.673;177.242;117.256;189.179;163.45;141.536;148.568;142.777;200.468;104.718;249.176;109.464;39.7754;162.134;254.954;163.744;130.074;194.92;3.282;183.659;197.092;127.579;216.691;57.6936;161.753;178.963 354.06;193.467;572.253;338.867;1285.89;348.781;992.735;452.105;484.566;506.507;497.741;2217.36;237.081;459.059;258.668;140.784;795.183;447.21;831.582;483.266;274.42;61.3966;299.409;3966.72;364.247;757.755;153.26;786.937;1374.01 20 9 20 246118;365377;311715;29483;84487;362282;24584;25595;24503;24494;24451;24450;24408;80841;25315;50549;25279;29182;24232;298566 TUBB3_32820;TRIM72_33144;TCFL5_9994;SLC1A3_32817;SLC17A6_32912;PCK1_9439;MYLPF_32295;MAP2_32650;INA_32322;IL1B_8892;HMOX1_8815;HMGCS2_8812;GRIN1_32381;FABP7_8592;EPHX1_8567;CYP4A1_33111;CYP24A1_32574;CDH22_32502;C3_8175;C1QA_8167 233.01529 268.95550000000003 104.17400434250128 154.85418 162.79199999999997 74.02536308484937 687.89108 405.7285 903.9808893185866 282.273;82.0928;270.921;303.435;369.631;227.854;353.211;145.437;305.642;153.991;61.2776;269.456;310.025;227.998;12.5094;375.605;189.111;307.062;144.319;268.455 238.208;49.3056;228.673;189.179;163.45;148.568;200.468;104.718;249.176;109.464;39.7754;162.134;254.954;194.92;3.282;197.092;127.579;216.691;57.6936;161.753 354.06;193.467;338.867;992.735;452.105;506.507;2217.36;237.081;459.059;258.668;140.784;795.183;447.21;274.42;61.3966;3966.72;364.247;757.755;153.26;786.937 9 360243;313506;78968;294228;338475;304729;84488;25311;29650 TOP2A_10059;STIL_33274;SREBF1_32750;RT1-S3_9763;NREP_9364;GLI2_8713;FGF13_32529;DCC_32537;ADAM10_7983 242.5298888888889 222.026 48.76235424855005 149.29922222222226 142.777 27.880282785410046 686.3886666666667 497.741 394.9120707214455 203.468;311.636;177.986;219.207;222.026;273.717;209.76;248.198;316.771 108.442;177.242;117.256;141.536;142.777;163.744;130.074;183.659;178.963 572.253;1285.89;348.781;484.566;497.741;831.582;483.266;299.409;1374.01 0 Exp 2,12(0.42);Exp 5,1(0.04);Hill,2(0.07);Linear,11(0.38);Poly 2,3(0.11) 1.9327628754554413 58.12034022808075 1.5347857475280762 5.283818244934082 0.7018572064378739 1.84465754032135 203.28545077920103 268.6507423242473 130.26323795653585 175.9972172158779 405.7177437409978 969.1318838452091 UP 0.6896551724137931 0.3103448275862069 0.0 GO:1990778 6 protein localization to cell periphery 38 42 3 3 3 3 3 3 56 39 2449 0.98491 0.071664 0.071664 7.14 25247;24408;84488 nsg1;grin1;fgf13 NSG1_32675;GRIN1_32381;FGF13_32529 245.41899999999998 216.472 209.76 56.05099609284398 245.52946881703343 57.417784842927716 183.75500000000002 166.237 130.074 64.2566248958034 179.45567959005322 68.96514583251364 424.3506666666667 447.21 342.576 73.0775674563222 446.37744085167236 61.56782460911975 1.5 263.2485 216.472;310.025;209.76 166.237;254.954;130.074 342.576;447.21;483.266 2 1 2 25247;24408 NSG1_32675;GRIN1_32381 263.2485 263.2485 66.15196070034504 210.59550000000002 210.59550000000002 62.73239230652676 394.89300000000003 394.89300000000003 73.98741094267318 216.472;310.025 166.237;254.954 342.576;447.21 1 84488 FGF13_32529 209.76 209.76 130.074 130.074 483.266 483.266 209.76 130.074 483.266 0 Exp 2,3(1) 2.22156824789317 7.01829731464386 1.6639630794525146 3.437419891357422 0.9592593085200167 1.9169143438339233 181.99132694220185 308.8466730577981 111.0417838256144 256.46821617438565 341.6556143111106 507.04571902222284 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0043490 6 malate-aspartate shuttle 2 2 1 1 1 1 1 1 58 1 2487 0.99947 0.045801 0.045801 50.0 29483 slc1a3 SLC1A3_32817 303.435 303.435 303.435 303.435 189.179 189.179 189.179 189.179 992.735 992.735 992.735 992.735 0.0 303.435 0.0 303.435 303.435 189.179 992.735 1 0 1 29483 SLC1A3_32817 303.435 303.435 189.179 189.179 992.735 992.735 303.435 189.179 992.735 0 0 Exp 2,1(1) 1.6762725114822388 1.6762725114822388 1.6762725114822388 1.6762725114822388 0.0 1.6762725114822388 303.435 303.435 189.179 189.179 992.735 992.735 UP 1.0 0.0 0.0 GO:0000165 8 MAPK cascade 43 45 2 2 2 2 2 2 57 43 2445 0.91558 0.28006 0.28006 4.44 24494;84488 il1b;fgf13 IL1B_8892;FGF13_32529 181.8755 181.8755 153.991 39.43463807999272 184.6859980914296 39.233823181741236 119.769 119.769 109.464 14.573470760254779 120.80764809597383 14.499257576353877 370.967 370.967 258.668 158.81476884093638 382.2856940834318 158.00602877894042 153.991;209.76 109.464;130.074 258.668;483.266 1 1 1 24494 IL1B_8892 153.991 153.991 109.464 109.464 258.668 258.668 153.991 109.464 258.668 1 84488 FGF13_32529 209.76 209.76 130.074 130.074 483.266 483.266 209.76 130.074 483.266 0 Exp 2,1(0.5);Linear,1(0.5) 2.185784674321412 4.535213470458984 1.6639630794525146 2.8712503910064697 0.8536810448402777 2.267606735229492 127.22188000000003 236.52911999999995 99.57119999999999 139.9668 150.86096 591.07304 CONFLICT 0.5 0.5 0.0 GO:0046394 6 carboxylic acid biosynthetic process 88 95 3 3 3 3 3 3 56 92 2396 0.82423 0.37897 0.48237 3.16 29483;24494;50549 slc1a3;il1b;cyp4a1 SLC1A3_32817;IL1B_8892;CYP4A1_33111 277.677 303.435 153.991 113.03007198086713 267.6096977844359 116.50565429080473 165.245 189.179 109.464 48.469514779910874 160.54937128439644 50.17567388239038 1739.3743333333332 992.735 258.668 1963.5465691539714 1632.1628428605218 1957.4779352098576 303.435;153.991;375.605 189.179;109.464;197.092 992.735;258.668;3966.72 3 0 3 29483;24494;50549 SLC1A3_32817;IL1B_8892;CYP4A1_33111 277.677 303.435 113.03007198086713 165.245 189.179 48.469514779910874 1739.3743333333332 992.735 1963.5465691539714 303.435;153.991;375.605 189.179;109.464;197.092 992.735;258.668;3966.72 0 0 Exp 2,1(0.34);Linear,2(0.67) 1.9669057703607475 6.128534197807312 1.5810112953186035 2.8712503910064697 0.7189997399047565 1.6762725114822388 149.7714327300343 405.58256726996575 110.3965806848827 220.09341931511733 -482.58778159079384 3961.3364482574602 UP 1.0 0.0 0.0 GO:0065007 2 biological regulation 1742 1890 61 59 52 44 39 39 20 1851 637 0.10088 0.94077 0.17436 2.06 29142;286989;246118;365377;360243;311715;366669;313506;78968;79212;29483;84487;294228;291773;362282;25247;338475;24567;58827;25595;361680;681410;24494;24451;24416;24408;304729;84488;80841;316098;316137;25311;245920;502902;363198;24232;298566;29650;170924 vnn1;ugt2b7;tubb3;trim72;top2a;tcfl5;syne2;stil;srebf1;slc6a1;slc1a3;slc17a6;rt1-s3;taf4b;pck1;nsg1;nrep;mt1;mest;map2;lsp1;loc681410;il1b;hmox1;grm3;grin1;gli2;fgf13;fabp7;exosc7;adgre1;dcc;cxcl10;clec7a;cenpq;c3;c1qa;adam10;abcc4 VNN1_10157;UGT2B7_33032;TUBB3_32820;TRIM72_33144;TOP2A_10059;TCFL5_9994;SYNE2_9977;STIL_33274;SREBF1_32750;SLC6A1_32594;SLC1A3_32817;SLC17A6_32912;RT1-S3_9763;RGD1562997_32695;PCK1_9439;NSG1_32675;NREP_9364;MT1A_9255;MEST_9219;MAP2_32650;LSP1_32853;LOC681410_33126;IL1B_8892;HMOX1_8815;GRM3_33234;GRIN1_32381;GLI2_8713;FGF13_32529;FABP7_8592;EXOSC7_8580;EMR1_8558;DCC_32537;CXCL10_8408;CLEC7A_32927;CENPQ_8290;C3_8175;C1QA_8167;ADAM10_7983;ABCC4_32768 232.14773256410257 233.741 4.13867 97.91024691397479 234.03356699898754 103.80026813311716 153.6066635897436 161.753 1.39768 74.089674225756 154.84383781464845 78.34660156009052 684.5572717948718 483.266 16.5686 1048.2466393611596 671.1030218121201 1063.6410302889087 233.741;4.13867;282.273;82.0928;203.468;270.921;276.757;311.636;177.986;145.445;303.435;369.631;219.207;279.902;227.854;216.472;222.026;392.753;272.228;145.437;231.535;410.591;153.991;61.2776;286.986;310.025;273.717;209.76;227.998;111.985;119.065;248.198;344.076;412.985;39.9715;144.319;268.455;316.771;244.652 147.819;1.39768;238.208;49.3056;108.442;228.673;164.88;177.242;117.256;104.722;189.179;163.45;141.536;166.045;148.568;166.237;142.777;211.395;198.842;104.718;141.502;326.66;109.464;39.7754;241.819;254.954;163.744;130.074;194.92;54.886;89.1701;183.659;187.725;338.673;12.1775;57.6936;161.753;178.963;152.355 556.851;16.5686;354.06;193.467;572.253;338.867;858.911;1285.89;348.781;237.101;992.735;452.105;484.566;888.462;506.507;342.576;497.741;6610.49;543.288;237.081;580.905;495.344;258.668;140.784;363.86;447.21;831.582;483.266;274.42;373.527;178.281;299.409;2052.67;488.745;177.403;153.26;786.937;1374.01;619.152 25 14 25 29142;286989;246118;365377;311715;79212;29483;84487;362282;25247;24567;58827;25595;681410;24494;24451;24416;24408;80841;316098;316137;502902;24232;298566;170924 VNN1_10157;UGT2B7_33032;TUBB3_32820;TRIM72_33144;TCFL5_9994;SLC6A1_32594;SLC1A3_32817;SLC17A6_32912;PCK1_9439;NSG1_32675;MT1A_9255;MEST_9219;MAP2_32650;LOC681410_33126;IL1B_8892;HMOX1_8815;GRM3_33234;GRIN1_32381;FABP7_8592;EXOSC7_8580;EMR1_8558;CLEC7A_32927;C3_8175;C1QA_8167;ABCC4_32768 227.95004279999998 233.741 109.94706992191051 158.9854952 161.753 86.57590058202827 638.4753840000001 363.86 1262.3189235213315 233.741;4.13867;282.273;82.0928;270.921;145.445;303.435;369.631;227.854;216.472;392.753;272.228;145.437;410.591;153.991;61.2776;286.986;310.025;227.998;111.985;119.065;412.985;144.319;268.455;244.652 147.819;1.39768;238.208;49.3056;228.673;104.722;189.179;163.45;148.568;166.237;211.395;198.842;104.718;326.66;109.464;39.7754;241.819;254.954;194.92;54.886;89.1701;338.673;57.6936;161.753;152.355 556.851;16.5686;354.06;193.467;338.867;237.101;992.735;452.105;506.507;342.576;6610.49;543.288;237.081;495.344;258.668;140.784;363.86;447.21;274.42;373.527;178.281;488.745;153.26;786.937;619.152 14 360243;366669;313506;78968;294228;291773;338475;361680;304729;84488;25311;245920;363198;29650 TOP2A_10059;SYNE2_9977;STIL_33274;SREBF1_32750;RT1-S3_9763;RGD1562997_32695;NREP_9364;LSP1_32853;GLI2_8713;FGF13_32529;DCC_32537;CXCL10_8408;CENPQ_8290;ADAM10_7983 239.64360714285718 239.8665 74.90305520064908 144.00160714285715 153.26049999999998 45.309585227282774 766.8463571428572 576.579 508.7338484740035 203.468;276.757;311.636;177.986;219.207;279.902;222.026;231.535;273.717;209.76;248.198;344.076;39.9715;316.771 108.442;164.88;177.242;117.256;141.536;166.045;142.777;141.502;163.744;130.074;183.659;187.725;12.1775;178.963 572.253;858.911;1285.89;348.781;484.566;888.462;497.741;580.905;831.582;483.266;299.409;2052.67;177.403;1374.01 0 Exp 2,14(0.36);Exp 4,1(0.03);Exp 5,1(0.03);Hill,2(0.06);Linear,15(0.39);Poly 2,6(0.16) 2.0605573306441087 83.93673276901245 1.5347857475280762 5.283818244934082 0.755315686712393 1.9169143438339233 201.41848589330996 262.8769792348952 130.35353180015395 176.8597953793333 355.5638255720244 1013.5507180177192 UP 0.6410256410256411 0.358974358974359 0.0 GO:0001649 5 osteoblast differentiation 27 27 3 3 3 2 2 2 57 25 2463 0.97672 0.12813 0.12813 7.41 304729;25279 gli2;cyp24a1 GLI2_8713;CYP24A1_32574 231.414 231.414 189.111 59.82547632906908 218.4513514482363 56.94758206497359 145.6615 145.6615 127.579 25.572516741611658 140.12059055061655 24.34235521570326 597.9145 597.9145 364.247 330.45574758581535 526.313202681388 314.5592306022563 0.5 231.414 273.717;189.111 163.744;127.579 831.582;364.247 1 1 1 25279 CYP24A1_32574 189.111 189.111 127.579 127.579 364.247 364.247 189.111 127.579 364.247 1 304729 GLI2_8713 273.717 273.717 163.744 163.744 831.582 831.582 273.717 163.744 831.582 0 Linear,2(1) 2.1765047200251115 4.353223085403442 2.1550474166870117 2.1981756687164307 0.030496279470724617 2.176611542701721 148.50011999999998 314.32788 110.21979999999999 181.1032 139.92620000000005 1055.9027999999998 CONFLICT 0.5 0.5 0.0 GO:0010604 6 positive regulation of macromolecule metabolic process 704 754 23 23 20 16 15 15 44 739 1749 0.28985 0.8025 0.56452 1.99 360243;313506;78968;294228;291773;362282;25247;681410;24494;24408;304729;84488;25311;502902;24232 top2a;stil;srebf1;rt1-s3;taf4b;pck1;nsg1;loc681410;il1b;grin1;gli2;fgf13;dcc;clec7a;c3 TOP2A_10059;STIL_33274;SREBF1_32750;RT1-S3_9763;RGD1562997_32695;PCK1_9439;NSG1_32675;LOC681410_33126;IL1B_8892;GRIN1_32381;GLI2_8713;FGF13_32529;DCC_32537;CLEC7A_32927;C3_8175 253.34073333333336 227.854 144.319 81.4894934713028 253.11794526878012 82.97504886500178 172.68317333333331 163.744 57.6936 78.43211305049078 173.5659691116679 80.22140197216757 525.7679333333333 484.566 153.26 285.8052367456019 513.896198760746 286.00974201178605 203.468;311.636;177.986;219.207;279.902;227.854;216.472;410.591;153.991;310.025;273.717;209.76;248.198;412.985;144.319 108.442;177.242;117.256;141.536;166.045;148.568;166.237;326.66;109.464;254.954;163.744;130.074;183.659;338.673;57.6936 572.253;1285.89;348.781;484.566;888.462;506.507;342.576;495.344;258.668;447.21;831.582;483.266;299.409;488.745;153.26 7 8 7 362282;25247;681410;24494;24408;502902;24232 PCK1_9439;NSG1_32675;LOC681410_33126;IL1B_8892;GRIN1_32381;CLEC7A_32927;C3_8175 268.03385714285713 227.854 112.30970130911592 200.32137142857144 166.237 108.4168231547379 384.61571428571426 447.21 137.25573599515405 227.854;216.472;410.591;153.991;310.025;412.985;144.319 148.568;166.237;326.66;109.464;254.954;338.673;57.6936 506.507;342.576;495.344;258.668;447.21;488.745;153.26 8 360243;313506;78968;294228;291773;304729;84488;25311 TOP2A_10059;STIL_33274;SREBF1_32750;RT1-S3_9763;RGD1562997_32695;GLI2_8713;FGF13_32529;DCC_32537 240.48424999999997 233.7025 45.439415045122104 148.49975 152.64 28.211725215641422 649.276125 528.4095 331.4574341710681 203.468;311.636;177.986;219.207;279.902;273.717;209.76;248.198 108.442;177.242;117.256;141.536;166.045;163.744;130.074;183.659 572.253;1285.89;348.781;484.566;888.462;831.582;483.266;299.409 0 Exp 2,6(0.4);Exp 5,1(0.07);Linear,5(0.34);Poly 2,3(0.2) 1.982493175648338 30.470144510269165 1.5889767408370972 3.437419891357422 0.5101358623457349 1.9169143438339233 212.1013597222494 294.5801069444173 132.99104769341875 212.375298973248 381.1305275025211 670.4053391641457 CONFLICT 0.4666666666666667 0.5333333333333333 0.0 GO:0070374 9 positive regulation of ERK1 and ERK2 cascade 75 80 6 6 5 4 3 3 56 77 2411 0.88798 0.28241 0.43123 3.75 24494;25311;24232 il1b;dcc;c3 IL1B_8892;DCC_32537;C3_8175 182.16933333333336 153.991 144.319 57.38663182600396 187.9896591501564 59.1891596998317 116.93886666666667 109.464 57.6936 63.31449852169198 123.55914449947862 63.87621480952622 237.11233333333334 258.668 153.26 75.4212677189487 244.2979227059437 73.81715455130899 153.991;248.198;144.319 109.464;183.659;57.6936 258.668;299.409;153.26 2 1 2 24494;24232 IL1B_8892;C3_8175 149.155 149.155 6.839136787636285 83.5788 83.5788 36.607200904740054 205.964 205.964 74.5347115913116 153.991;144.319 109.464;57.6936 258.668;153.26 1 25311 DCC_32537 248.198 248.198 183.659 183.659 299.409 299.409 248.198 183.659 299.409 0 Exp 5,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 2.1240379406806507 6.530914306640625 1.7257766723632812 2.8712503910064697 0.6102007484643234 1.933887243270874 117.2302461613798 247.10842050528686 45.29176684706084 188.5859664862725 151.76513446182392 322.45953220484273 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0007411 5 axon guidance 40 45 4 4 4 4 4 4 55 41 2447 0.99663 0.019077 0.019077 8.89 246118;311024;304729;25311 tubb3;kif5c;gli2;dcc TUBB3_32820;KIF5C_8965;GLI2_8713;DCC_32537 265.25125 265.267 248.198 15.528026326075775 267.1186535506044 16.208585086193253 198.48 195.98399999999998 163.744 32.15159385370093 205.01736768737692 33.09753951559505 464.3225 363.1495 299.409 246.78816334459813 434.6624555353902 221.68540205447815 1.5 265.267 282.273;256.817;273.717;248.198 238.208;208.309;163.744;183.659 354.06;372.239;831.582;299.409 2 2 2 246118;311024 TUBB3_32820;KIF5C_8965 269.545 269.545 18.00011022188407 223.2585 223.2585 21.14178565069658 363.1495 363.1495 12.854494175189998 282.273;256.817 238.208;208.309 354.06;372.239 2 304729;25311 GLI2_8713;DCC_32537 260.9575 260.9575 18.044657949100255 173.7015 173.7015 14.082031547329832 565.4955 565.4955 376.30313706438864 273.717;248.198 163.744;183.659 831.582;299.409 0 Exp 2,2(0.5);Linear,1(0.25);Poly 2,1(0.25) 2.245701780974249 9.027956247329712 1.933887243270874 2.545419454574585 0.2580602663438514 2.2743247747421265 250.03378420044479 280.4687157995553 166.97143802337317 229.9885619766268 222.4700999222939 706.1749000777061 CONFLICT 0.5 0.5 0.0 GO:1902531 6 regulation of intracellular signal transduction 377 399 11 10 8 5 4 4 55 395 2093 0.033866 0.98867 0.06784 1.0 29142;24494;25311;24232 vnn1;il1b;dcc;c3 VNN1_10157;IL1B_8892;DCC_32537;C3_8175 195.06225 193.866 144.319 53.48264088078802 194.3554202199282 54.90990224108274 124.65889999999999 128.6415 57.6936 53.95256689018604 126.93461811041291 56.71139450000104 317.047 279.0385 153.26 171.3197268948713 287.78600796678637 140.60976371289627 233.741;153.991;248.198;144.319 147.819;109.464;183.659;57.6936 556.851;258.668;299.409;153.26 3 1 3 29142;24494;24232 VNN1_10157;IL1B_8892;C3_8175 177.35033333333334 153.991 49.07461014958076 104.99219999999998 109.464 45.228803629103474 322.92633333333333 258.668 209.32814878160394 233.741;153.991;144.319 147.819;109.464;57.6936 556.851;258.668;153.26 1 25311 DCC_32537 248.198 248.198 183.659 183.659 299.409 299.409 248.198 183.659 299.409 0 Exp 5,1(0.25);Linear,2(0.5);Poly 2,1(0.25) 2.073689154931465 8.460605502128601 1.7257766723632812 2.8712503910064697 0.5133389214075275 1.931789219379425 142.64926193682777 247.47523806317224 71.78538444761767 177.53241555238236 149.153667643026 484.94033235697407 UP 0.75 0.25 0.0 GO:0033036 3 macromolecule localization 295 315 10 10 9 8 7 7 52 308 2180 0.55147 0.60788 1.0 2.22 366669;313506;78968;25247;311024;24408;84488 syne2;stil;srebf1;nsg1;kif5c;grin1;fgf13 SYNE2_9977;STIL_33274;SREBF1_32750;NSG1_32675;KIF5C_8965;GRIN1_32381;FGF13_32529 251.35042857142858 256.817 177.986 51.770391534341755 251.92011813291137 51.87116512459237 174.136 166.237 117.256 46.60803269466184 173.70841348101266 47.85538427157967 591.2675714285715 447.21 342.576 354.77011255499764 598.6803706329114 358.02696858701654 276.757;311.636;177.986;216.472;256.817;310.025;209.76 164.88;177.242;117.256;166.237;208.309;254.954;130.074 858.911;1285.89;348.781;342.576;372.239;447.21;483.266 3 4 3 25247;311024;24408 NSG1_32675;KIF5C_8965;GRIN1_32381 261.1046666666667 256.817 46.923650927153396 209.83333333333334 208.309 44.37813894625732 387.3416666666667 372.239 53.92713968247619 216.472;256.817;310.025 166.237;208.309;254.954 342.576;372.239;447.21 4 366669;313506;78968;84488 SYNE2_9977;STIL_33274;SREBF1_32750;FGF13_32529 244.03474999999997 243.2585 61.04061628880143 147.363 147.477 28.313370810743503 744.212 671.0885 420.7253288318482 276.757;311.636;177.986;209.76 164.88;177.242;117.256;130.074 858.911;1285.89;348.781;483.266 0 Exp 2,5(0.72);Linear,2(0.29) 1.974575840414724 14.340814709663391 1.5889767408370972 3.437419891357422 0.6655847710878617 1.748702883720398 212.99838581406124 289.7024713287959 139.608286189748 208.663713810252 328.4501941112746 854.0849487458681 CONFLICT 0.42857142857142855 0.5714285714285714 0.0 GO:0030162 7 regulation of proteolysis 214 230 6 6 6 4 4 4 55 226 2262 0.3722 0.79465 0.81671 1.74 24494;24408;502902;24232 il1b;grin1;clec7a;c3 IL1B_8892;GRIN1_32381;CLEC7A_32927;C3_8175 255.33 232.00799999999998 144.319 129.66582316606534 269.88508254311404 135.24415051814583 190.19615 182.209 57.6936 129.5036163235993 204.2530877118852 133.12439895457356 336.97074999999995 352.93899999999996 153.26 158.1866782494132 351.31556188276903 157.9794770263033 153.991;310.025;412.985;144.319 109.464;254.954;338.673;57.6936 258.668;447.21;488.745;153.26 4 0 4 24494;24408;502902;24232 IL1B_8892;GRIN1_32381;CLEC7A_32927;C3_8175 255.33 232.00799999999998 129.66582316606534 190.19615 182.209 129.5036163235993 336.97074999999995 352.93899999999996 158.1866782494132 153.991;310.025;412.985;144.319 109.464;254.954;338.673;57.6936 258.668;447.21;488.745;153.26 0 0 Exp 2,1(0.25);Exp 5,1(0.25);Linear,1(0.25);Poly 2,1(0.25) 2.113303712964004 8.613796353340149 1.7257766723632812 2.8712503910064697 0.5023157781496055 2.008384644985199 128.25749329725593 382.40250670274406 63.28260600287274 317.10969399712724 181.94780531557518 491.9936946844247 UP 1.0 0.0 0.0 GO:0051129 6 negative regulation of cellular component organization 177 187 6 6 6 5 5 5 54 182 2306 0.73731 0.4387 0.61797 2.67 360243;25595;24494;84488;245920 top2a;map2;il1b;fgf13;cxcl10 TOP2A_10059;MAP2_32650;IL1B_8892;FGF13_32529;CXCL10_8408 211.3464 203.468 145.437 79.55410656465202 234.67912332589282 85.71492540169302 128.0846 109.464 104.718 34.78322691758203 139.13912541852676 37.687067336602844 720.7876 483.266 237.081 758.273757438763 917.711900018601 858.2068115213871 203.468;145.437;153.991;209.76;344.076 108.442;104.718;109.464;130.074;187.725 572.253;237.081;258.668;483.266;2052.67 2 3 2 25595;24494 MAP2_32650;IL1B_8892 149.714 149.714 6.048591406270443 107.09100000000001 107.09100000000001 3.3559287835111813 247.8745 247.8745 15.264314085473336 145.437;153.991 104.718;109.464 237.081;258.668 3 360243;84488;245920 TOP2A_10059;FGF13_32529;CXCL10_8408 252.43466666666666 209.76 79.42605238417278 142.08033333333333 130.074 40.98246640129577 1036.063 572.253 881.5310634793308 203.468;209.76;344.076 108.442;130.074;187.725 572.253;483.266;2052.67 0 Exp 2,2(0.4);Linear,3(0.6) 2.2056492220262403 11.211949825286865 1.6639630794525146 2.8712503910064697 0.4532562973112982 2.1256394386291504 141.61415105421295 281.078648945787 97.59575733311058 158.5734426668894 56.1313464625938 1385.443853537406 DOWN 0.4 0.6 0.0 GO:0055085 4 transmembrane transport 188 198 9 9 7 7 5 5 54 193 2295 0.69216 0.48986 0.80424 2.53 79212;29483;84487;24408;170924 slc6a1;slc1a3;slc17a6;grin1;abcc4 SLC6A1_32594;SLC1A3_32817;SLC17A6_32912;GRIN1_32381;ABCC4_32768 274.63759999999996 303.435 145.445 84.69824152720061 270.75584384283013 100.21699540233661 172.93200000000002 163.45 104.722 55.130524317296185 161.52093687550632 54.03593607902812 549.6605999999999 452.105 237.101 282.3343331465376 478.74296874156084 259.2773931581951 145.445;303.435;369.631;310.025;244.652 104.722;189.179;163.45;254.954;152.355 237.101;992.735;452.105;447.21;619.152 5 0 5 79212;29483;84487;24408;170924 SLC6A1_32594;SLC1A3_32817;SLC17A6_32912;GRIN1_32381;ABCC4_32768 274.63759999999996 303.435 84.69824152720061 172.93200000000002 163.45 55.130524317296185 549.6605999999999 452.105 282.3343331465376 145.445;303.435;369.631;310.025;244.652 104.722;189.179;163.45;254.954;152.355 237.101;992.735;452.105;447.21;619.152 0 0 Exp 2,2(0.4);Hill,1(0.2);Linear,2(0.4) 1.7928746516493566 9.00474762916565 1.5415009260177612 2.0017645359039307 0.18786158205046144 1.8682953119277954 200.39631795322975 348.8788820467703 124.60796479659754 221.2560352034025 302.18364557128996 797.1375544287101 UP 1.0 0.0 0.0 GO:1903539 7 protein localization to postsynaptic membrane 6 6 2 2 2 2 2 2 57 4 2484 0.99978 0.0074544 0.0074544 33.33 25247;24408 nsg1;grin1 NSG1_32675;GRIN1_32381 263.2485 263.2485 216.472 66.15196070034504 278.6974221405604 62.4399192335304 210.59550000000002 210.59550000000002 166.237 62.73239230652676 225.2458268259072 59.21223600142323 394.89300000000003 394.89300000000003 342.576 73.98741094267318 412.17178870004597 69.8356921646679 0.0 216.472 0.0 216.472 216.472;310.025 166.237;254.954 342.576;447.21 2 0 2 25247;24408 NSG1_32675;GRIN1_32381 263.2485 263.2485 66.15196070034504 210.59550000000002 210.59550000000002 62.73239230652676 394.89300000000003 394.89300000000003 73.98741094267318 216.472;310.025 166.237;254.954 342.576;447.21 0 0 Exp 2,2(1) 2.566951401083217 5.354334235191345 1.9169143438339233 3.437419891357422 1.0751597834856301 2.6771671175956726 171.56656 354.93044 123.65284000000001 297.53816 292.3516800000001 497.43431999999996 UP 1.0 0.0 0.0 GO:0009968 6 negative regulation of signal transduction 284 297 11 11 9 6 5 5 54 292 2196 0.298 0.83576 0.54212 1.68 29142;365377;24494;24451;304729 vnn1;trim72;il1b;hmox1;gli2 VNN1_10157;TRIM72_33144;IL1B_8892;HMOX1_8815;GLI2_8713 160.96388 153.991 61.2776 92.48837494697378 145.42671670521403 91.03657788832376 102.02159999999999 109.464 39.7754 56.1605108076841 91.93828403327245 55.60071818668028 396.2704 258.668 140.784 291.8129787694509 358.31987839318316 290.2841244947048 233.741;82.0928;153.991;61.2776;273.717 147.819;49.3056;109.464;39.7754;163.744 556.851;193.467;258.668;140.784;831.582 4 1 4 29142;365377;24494;24451 VNN1_10157;TRIM72_33144;IL1B_8892;HMOX1_8815 132.7756 118.0419 78.15543362249363 86.591 79.3848 51.166211407920365 287.4425 226.0675 185.96507014759518 233.741;82.0928;153.991;61.2776 147.819;49.3056;109.464;39.7754 556.851;193.467;258.668;140.784 1 304729 GLI2_8713 273.717 273.717 163.744 163.744 831.582 831.582 273.717 163.744 831.582 0 Linear,3(0.6);Poly 2,2(0.4) 2.0038928288036546 10.257610321044922 1.5923793315887451 2.8712503910064697 0.5166372517942167 1.929691195487976 79.89424494411064 242.03351505588932 52.794741831699454 151.24845816830054 140.48504635988354 652.0557536401164 UP 0.8 0.2 0.0 GO:1901576 4 organic substance biosynthetic process 397 444 13 13 11 11 10 10 49 434 2054 0.54405 0.59409 1.0 2.25 78968;29483;291773;303872;362282;24494;24450;25315;50549;64564 srebf1;slc1a3;taf4b;pigz;pck1;il1b;hmgcs2;ephx1;cyp4a1;bbox1 SREBF1_32750;SLC1A3_32817;RGD1562997_32695;PIGZ_32744;PCK1_9439;IL1B_8892;HMGCS2_8812;EPHX1_8567;CYP4A1_33111;BBOX1_8133 261.00834 274.679 12.5094 125.94149651008776 271.87146034589864 108.71968564298018 156.4957 164.0895 3.282 69.81207276212652 164.12675074378004 56.51310856237073 876.9213599999999 498.839 61.3966 1123.1655895717277 962.713300630987 1247.4658848735755 177.986;303.435;279.902;355.097;227.854;153.991;269.456;12.5094;375.605;454.248 117.256;189.179;166.045;212.48;148.568;109.464;162.134;3.282;197.092;259.457 348.781;992.735;888.462;459.59;506.507;258.668;795.183;61.3966;3966.72;491.171 8 2 8 29483;303872;362282;24494;24450;25315;50549;64564 SLC1A3_32817;PIGZ_32744;PCK1_9439;IL1B_8892;HMGCS2_8812;EPHX1_8567;CYP4A1_33111;BBOX1_8133 269.024425 286.44550000000004 138.86663931974186 160.207 175.6565 77.57245126055659 941.496325 498.839 1255.9051169410798 303.435;355.097;227.854;153.991;269.456;12.5094;375.605;454.248 189.179;212.48;148.568;109.464;162.134;3.282;197.092;259.457 992.735;459.59;506.507;258.668;795.183;61.3966;3966.72;491.171 2 78968;291773 SREBF1_32750;RGD1562997_32695 228.944 228.944 72.06549471140809 141.6505 141.6505 34.499032747310494 618.6215 618.6215 381.61209477753727 177.986;279.902 117.256;166.045 348.781;888.462 0 Exp 2,3(0.3);Hill,1(0.1);Linear,4(0.4);Poly 2,1(0.1);Power,1(0.1) 1.9700271990122529 20.151053071022034 1.5810112953186035 2.8712503910064697 0.4726979051957938 1.8766838908195496 182.94899174320318 339.06768825679677 113.22572901127849 199.76567098872152 180.77611529578576 1573.0666047042143 UP 0.8 0.2 0.0 GO:0051253 7 negative regulation of RNA metabolic process 238 250 8 8 6 6 5 5 54 245 2243 0.47156 0.70224 1.0 2.0 311715;78968;681410;24494;304729 tcfl5;srebf1;loc681410;il1b;gli2 TCFL5_9994;SREBF1_32750;LOC681410_33126;IL1B_8892;GLI2_8713 257.4412 270.921 153.991 101.1391870157162 239.88586948906567 93.11779089498204 189.1594 163.744 109.464 90.32598996855779 171.03069789320924 81.29598485691632 454.64840000000004 348.781 258.668 227.35249438987904 461.02459865885993 246.63561907057993 270.921;177.986;410.591;153.991;273.717 228.673;117.256;326.66;109.464;163.744 338.867;348.781;495.344;258.668;831.582 3 2 3 311715;681410;24494 TCFL5_9994;LOC681410_33126;IL1B_8892 278.50100000000003 270.921 128.46782593318838 221.59900000000002 228.673 108.77066107641342 364.29300000000006 338.867 120.36919602207172 270.921;410.591;153.991 228.673;326.66;109.464 338.867;495.344;258.668 2 78968;304729 SREBF1_32750;GLI2_8713 225.8515 225.8515 67.69203926976942 140.5 140.5 32.8719800438003 590.1815 590.1815 341.3918610636464 177.986;273.717 117.256;163.744 348.781;831.582 0 Exp 2,2(0.4);Linear,2(0.4);Poly 2,1(0.2) 2.000671991458596 10.2357177734375 1.5889767408370972 2.8712503910064697 0.5127820476276057 1.84465754032135 168.78879383636752 346.09360616363244 109.98517894777358 268.3336210522264 255.36515213451565 653.9316478654844 UP 0.6 0.4 0.0 GO:0022603 5 regulation of anatomical structure morphogenesis 271 280 11 11 11 8 8 8 51 272 2216 0.80637 0.31939 0.52528 2.86 25595;24494;24451;24408;84488;245920;24232;29650 map2;il1b;hmox1;grin1;fgf13;cxcl10;c3;adam10 MAP2_32650;IL1B_8892;HMOX1_8815;GRIN1_32381;FGF13_32529;CXCL10_8408;C3_8175;ADAM10_7983 210.707075 181.8755 61.2776 102.20093225344658 213.36994358001263 104.59038655727116 132.920875 119.769 39.7754 71.41869227709729 133.35427964217945 73.33979095181748 643.3686250000001 352.93899999999996 140.784 695.900261308213 689.2715010692449 769.4216900203085 145.437;153.991;61.2776;310.025;209.76;344.076;144.319;316.771 104.718;109.464;39.7754;254.954;130.074;187.725;57.6936;178.963 237.081;258.668;140.784;447.21;483.266;2052.67;153.26;1374.01 5 3 5 25595;24494;24451;24408;24232 MAP2_32650;IL1B_8892;HMOX1_8815;GRIN1_32381;C3_8175 163.00992 145.437 90.41902123686145 113.321 104.718 84.63474117807652 247.4006 237.081 122.86862571380867 145.437;153.991;61.2776;310.025;144.319 104.718;109.464;39.7754;254.954;57.6936 237.081;258.668;140.784;447.21;153.26 3 84488;245920;29650 FGF13_32529;CXCL10_8408;ADAM10_7983 290.20233333333334 316.771 70.99026341924176 165.58733333333336 178.963 31.065910486147388 1303.3153333333332 1374.01 787.0867364689443 209.76;344.076;316.771 130.074;187.725;178.963 483.266;2052.67;1374.01 0 Exp 2,2(0.25);Exp 5,1(0.13);Linear,4(0.5);Poly 2,1(0.13) 1.9593308321748333 16.009756088256836 1.5923793315887451 2.8712503910064697 0.4604896533691859 1.8213455080986023 139.885442204801 281.528707795199 83.43024621964142 182.41150378035857 161.13434707548265 1125.6029029245174 UP 0.625 0.375 0.0 GO:0048731 4 system development 102 110 5 5 4 2 2 2 57 108 2380 0.52693 0.73278 1.0 1.82 24503;304729 ina;gli2 INA_32322;GLI2_8713 289.67949999999996 289.67949999999996 273.717 22.5743839893812 288.8570842391304 22.544402345872488 206.45999999999998 206.45999999999998 163.744 60.40954653032924 204.25919739130433 60.32931499491033 645.3205 645.3205 459.059 263.41353944795634 654.9170164130435 263.06369287677916 305.642;273.717 249.176;163.744 459.059;831.582 1 1 1 24503 INA_32322 305.642 305.642 249.176 249.176 459.059 459.059 305.642 249.176 459.059 1 304729 GLI2_8713 273.717 273.717 163.744 163.744 831.582 831.582 273.717 163.744 831.582 0 Exp 2,1(0.5);Linear,1(0.5) 1.9382891794886759 3.907304286956787 1.7091286182403564 2.1981756687164307 0.3458084857109119 1.9536521434783936 258.393 320.96599999999995 122.73664000000001 290.18335999999994 280.2479600000001 1010.3930399999999 CONFLICT 0.5 0.5 0.0 GO:0070887 4 cellular response to chemical stimulus 594 635 24 24 20 15 13 13 46 622 1866 0.36452 0.74495 0.76066 2.05 78968;362282;24567;25595;361680;24503;24494;24451;24450;24408;304729;25315;245920 srebf1;pck1;mt1;map2;lsp1;ina;il1b;hmox1;hmgcs2;grin1;gli2;ephx1;cxcl10 SREBF1_32750;PCK1_9439;MT1A_9255;MAP2_32650;LSP1_32853;INA_32322;IL1B_8892;HMOX1_8815;HMGCS2_8812;GRIN1_32381;GLI2_8713;EPHX1_8567;CXCL10_8408 223.55838461538463 231.535 12.5094 110.28984783371074 246.13143347055507 107.55090144135067 145.66872307692307 148.568 3.282 73.4005516044005 159.1488087316376 70.15176343579768 1025.4089692307693 459.059 61.3966 1752.1400462110075 1285.3511334098882 1956.499327759839 177.986;227.854;392.753;145.437;231.535;305.642;153.991;61.2776;269.456;310.025;273.717;12.5094;344.076 117.256;148.568;211.395;104.718;141.502;249.176;109.464;39.7754;162.134;254.954;163.744;3.282;187.725 348.781;506.507;6610.49;237.081;580.905;459.059;258.668;140.784;795.183;447.21;831.582;61.3966;2052.67 9 4 9 362282;24567;25595;24503;24494;24451;24450;24408;25315 PCK1_9439;MT1A_9255;MAP2_32650;INA_32322;IL1B_8892;HMOX1_8815;HMGCS2_8812;GRIN1_32381;EPHX1_8567 208.77166666666665 227.854 124.90873279374829 142.60737777777777 148.568 87.78329476349383 1057.3754 447.21 2094.1136823673496 227.854;392.753;145.437;305.642;153.991;61.2776;269.456;310.025;12.5094 148.568;211.395;104.718;249.176;109.464;39.7754;162.134;254.954;3.282 506.507;6610.49;237.081;459.059;258.668;140.784;795.183;447.21;61.3966 4 78968;361680;304729;245920 SREBF1_32750;LSP1_32853;GLI2_8713;CXCL10_8408 256.82849999999996 252.62599999999998 70.12666786370717 152.55675000000002 152.623 30.167923465992676 953.4845 706.2435 758.8479842605718 177.986;231.535;273.717;344.076 117.256;141.502;163.744;187.725 348.781;580.905;831.582;2052.67 0 Exp 2,6(0.47);Hill,1(0.08);Linear,5(0.39);Poly 2,1(0.08) 1.9942793545679383 26.289740681648254 1.5889767408370972 2.8712503910064697 0.36289864792874915 1.9169143438339233 163.6041403850748 283.51262884569445 105.76772870648213 185.56971744736407 72.9347903323877 1977.8831481291504 UP 0.6923076923076923 0.3076923076923077 0.0 GO:0032386 6 regulation of intracellular transport 104 109 3 3 3 3 3 3 56 106 2382 0.75587 0.46697 0.73891 2.75 78968;25595;24451 srebf1;map2;hmox1 SREBF1_32750;MAP2_32650;HMOX1_8815 128.23353333333333 145.437 61.2776 60.22609157710079 121.19785628543498 68.56586389674709 87.24980000000001 104.718 39.7754 41.58923361303976 80.44471233626588 46.10731955201609 242.21533333333332 237.081 140.784 104.09351101933943 242.30934740957966 120.96464220663563 177.986;145.437;61.2776 117.256;104.718;39.7754 348.781;237.081;140.784 2 1 2 25595;24451 MAP2_32650;HMOX1_8815 103.35730000000001 103.35730000000001 59.50968244059112 72.2467 72.2467 45.92135284788549 188.9325 188.9325 68.09226170792091 145.437;61.2776 104.718;39.7754 237.081;140.784 1 78968 SREBF1_32750 177.986 177.986 117.256 117.256 348.781 348.781 177.986 117.256 348.781 0 Exp 2,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 1.7520690735834292 5.306995511054993 1.5889767408370972 2.1256394386291504 0.30886479528158495 1.5923793315887451 60.081294972148044 196.3857716945186 40.187151765117605 134.31244823488237 124.4224367818319 360.00822988483475 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0002675 8 positive regulation of acute inflammatory response 13 17 3 3 3 3 3 3 56 14 2474 0.99951 0.0063741 0.0063741 17.65 294228;24494;24232 rt1-s3;il1b;c3 RT1-S3_9763;IL1B_8892;C3_8175 172.50566666666668 153.991 144.319 40.73263798642701 183.51939238845142 42.92450095873512 102.89786666666667 109.464 57.6936 42.30511304385479 112.65620774278214 41.31889001853474 298.8313333333333 258.668 153.26 169.2652841469076 343.62205052493437 174.88248319126717 0.0 144.319 0.5 149.155 219.207;153.991;144.319 141.536;109.464;57.6936 484.566;258.668;153.26 2 1 2 24494;24232 IL1B_8892;C3_8175 149.155 149.155 6.839136787636285 83.5788 83.5788 36.607200904740054 205.964 205.964 74.5347115913116 153.991;144.319 109.464;57.6936 258.668;153.26 1 294228 RT1-S3_9763 219.207 219.207 141.536 141.536 484.566 484.566 219.207 141.536 484.566 0 Exp 5,1(0.34);Linear,2(0.67) 2.0681117969491942 6.382142782211304 1.7257766723632812 2.8712503910064697 0.6448927157052297 1.7851157188415527 126.4123476343827 218.59898569895063 55.025124594891125 150.7706087384422 107.28963289464926 490.3730337720174 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0031669 5 cellular response to nutrient levels 87 92 4 4 3 4 3 3 56 89 2399 0.83789 0.35969 0.47092 3.26 78968;362282;24451 srebf1;pck1;hmox1 SREBF1_32750;PCK1_9439;HMOX1_8815 155.70586666666668 177.986 61.2776 85.49402034793619 133.23698937887033 80.64208977869633 101.86646666666667 117.256 39.7754 56.005229718780164 87.30700517920809 53.116389351497794 332.024 348.781 140.784 183.43643577272212 278.2739630324638 161.73578124497368 177.986;227.854;61.2776 117.256;148.568;39.7754 348.781;506.507;140.784 2 1 2 362282;24451 PCK1_9439;HMOX1_8815 144.5658 144.5658 117.78730202564284 94.1717 94.1717 76.92798520291561 323.64549999999997 323.64549999999997 258.60521333588775 227.854;61.2776 148.568;39.7754 506.507;140.784 1 78968 SREBF1_32750 177.986 177.986 117.256 117.256 348.781 348.781 177.986 117.256 348.781 0 Exp 2,2(0.67);Poly 2,1(0.34) 1.7622230087924078 5.344166874885559 1.5889767408370972 2.162810802459717 0.3303253877775054 1.5923793315887451 58.96027516917741 252.45145816415595 38.490583136504156 165.2423501968292 124.44613187776943 539.6018681222306 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0044271 5 cellular nitrogen compound biosynthetic process 201 229 4 4 3 4 3 3 56 226 2262 0.20825 0.91186 0.36332 1.31 78968;291773;64564 srebf1;taf4b;bbox1 SREBF1_32750;RGD1562997_32695;BBOX1_8133 304.0453333333333 279.902 177.986 139.70450447044763 260.3318924235066 132.40755795914038 180.91933333333336 166.045 117.256 72.2579784129983 158.7579061437591 67.98533155944672 576.138 491.171 348.781 279.69347285376546 508.57520519669737 270.7462218087148 177.986;279.902;454.248 117.256;166.045;259.457 348.781;888.462;491.171 1 2 1 64564 BBOX1_8133 454.248 454.248 259.457 259.457 491.171 491.171 454.248 259.457 491.171 2 78968;291773 SREBF1_32750;RGD1562997_32695 228.944 228.944 72.06549471140809 141.6505 141.6505 34.499032747310494 618.6215 618.6215 381.61209477753727 177.986;279.902 117.256;166.045 348.781;888.462 0 Exp 2,1(0.34);Linear,1(0.34);Power,1(0.34) 1.93371853394304 6.004921793937683 1.5889767408370972 2.7777180671691895 0.6725537713065656 1.6382269859313965 145.95480413782147 462.1358625288451 99.15173328916153 262.6869333775051 259.6350403883025 892.6409596116973 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0050729 7 positive regulation of inflammatory response 47 52 4 4 4 4 4 4 55 48 2440 0.99366 0.030759 0.030759 7.69 294228;24494;502902;24232 rt1-s3;il1b;clec7a;c3 RT1-S3_9763;IL1B_8892;CLEC7A_32927;C3_8175 232.62550000000002 186.599 144.319 124.75446273246766 244.7427263360462 122.20727162916951 161.84165000000002 125.5 57.6936 122.84391221257155 172.9593690494327 120.1529606994696 346.30975 371.61699999999996 153.26 167.68211336210942 382.34206129976343 159.45388135108433 1.5 186.599 219.207;153.991;412.985;144.319 141.536;109.464;338.673;57.6936 484.566;258.668;488.745;153.26 3 1 3 24494;502902;24232 IL1B_8892;CLEC7A_32927;C3_8175 237.09833333333336 153.991 152.39906997528993 168.6102 109.464 149.53615127092178 300.22433333333333 258.668 171.55973576668075 153.991;412.985;144.319 109.464;338.673;57.6936 258.668;488.745;153.26 1 294228 RT1-S3_9763 219.207 219.207 141.536 141.536 484.566 484.566 219.207 141.536 484.566 0 Exp 5,1(0.25);Linear,2(0.5);Poly 2,1(0.25) 2.076002311978457 8.481997728347778 1.7257766723632812 2.8712503910064697 0.5267325346805143 1.9424853324890137 110.36612652218166 354.8848734778183 41.45461603167982 282.2286839683202 181.98127890513268 510.6382210948672 UP 0.75 0.25 0.0 GO:0007224 6 smoothened signaling pathway 6 6 2 2 2 2 2 2 57 4 2484 0.99978 0.0074544 0.0074544 33.33 313506;304729 stil;gli2 STIL_33274;GLI2_8713 292.67650000000003 292.67650000000003 273.717 26.812782035812145 292.7856194244604 26.812337951071804 170.493 170.493 163.744 9.544527332455957 170.53184316546762 9.544369251920418 1058.736 1058.736 831.582 321.2442675472976 1060.0433611510791 321.2389469626017 0.0 273.717 0.0 273.717 311.636;273.717 177.242;163.744 1285.89;831.582 0 2 0 2 313506;304729 STIL_33274;GLI2_8713 292.67650000000003 292.67650000000003 26.812782035812145 170.493 170.493 9.544527332455957 1058.736 1058.736 321.2442675472976 311.636;273.717 177.242;163.744 1285.89;831.582 0 Linear,2(1) 1.8954205169709875 3.8325395584106445 1.6343638896942139 2.1981756687164307 0.3986751322594607 1.9162697792053223 255.51587999999998 329.8371200000001 157.26496 183.72104 613.5141600000001 1503.95784 DOWN 0.0 1.0 0.0 GO:0048519 4 negative regulation of biological process 1024 1094 33 33 30 23 21 21 38 1073 1415 0.15322 0.90212 0.28769 1.92 29142;365377;360243;311715;313506;78968;79212;294228;24567;25595;681410;24494;24451;24408;304729;84488;80841;316098;245920;24232;29650 vnn1;trim72;top2a;tcfl5;stil;srebf1;slc6a1;rt1-s3;mt1;map2;loc681410;il1b;hmox1;grin1;gli2;fgf13;fabp7;exosc7;cxcl10;c3;adam10 VNN1_10157;TRIM72_33144;TOP2A_10059;TCFL5_9994;STIL_33274;SREBF1_32750;SLC6A1_32594;RT1-S3_9763;MT1A_9255;MAP2_32650;LOC681410_33126;IL1B_8892;HMOX1_8815;GRIN1_32381;GLI2_8713;FGF13_32529;FABP7_8592;EXOSC7_8580;CXCL10_8408;C3_8175;ADAM10_7983 226.05701904761904 219.207 61.2776 97.8815030462836 217.94062935063008 97.13558214740078 147.14131428571426 141.536 39.7754 72.83354448679741 139.99185183706837 67.82897916082734 845.2422857142857 447.21 140.784 1403.6470547834003 854.9619208908799 1437.4241363626704 233.741;82.0928;203.468;270.921;311.636;177.986;145.445;219.207;392.753;145.437;410.591;153.991;61.2776;310.025;273.717;209.76;227.998;111.985;344.076;144.319;316.771 147.819;49.3056;108.442;228.673;177.242;117.256;104.722;141.536;211.395;104.718;326.66;109.464;39.7754;254.954;163.744;130.074;194.92;54.886;187.725;57.6936;178.963 556.851;193.467;572.253;338.867;1285.89;348.781;237.101;484.566;6610.49;237.081;495.344;258.668;140.784;447.21;831.582;483.266;274.42;373.527;2052.67;153.26;1374.01 13 8 13 29142;365377;311715;79212;24567;25595;681410;24494;24451;24408;80841;316098;24232 VNN1_10157;TRIM72_33144;TCFL5_9994;SLC6A1_32594;MT1A_9255;MAP2_32650;LOC681410_33126;IL1B_8892;HMOX1_8815;GRIN1_32381;FABP7_8592;EXOSC7_8580;C3_8175 206.96741538461538 153.991 112.54334719444655 144.9988923076923 109.464 91.04943576272605 793.6207692307692 274.42 1752.5199421185462 233.741;82.0928;270.921;145.445;392.753;145.437;410.591;153.991;61.2776;310.025;227.998;111.985;144.319 147.819;49.3056;228.673;104.722;211.395;104.718;326.66;109.464;39.7754;254.954;194.92;54.886;57.6936 556.851;193.467;338.867;237.101;6610.49;237.081;495.344;258.668;140.784;447.21;274.42;373.527;153.26 8 360243;313506;78968;294228;304729;84488;245920;29650 TOP2A_10059;STIL_33274;SREBF1_32750;RT1-S3_9763;GLI2_8713;FGF13_32529;CXCL10_8408;ADAM10_7983 257.077625 246.462 62.32188364322188 150.62275 152.64 30.37356516422983 929.12725 701.9175 592.5310922963694 203.468;311.636;177.986;219.207;273.717;209.76;344.076;316.771 108.442;177.242;117.256;141.536;163.744;130.074;187.725;178.963 572.253;1285.89;348.781;484.566;831.582;483.266;2052.67;1374.01 0 Exp 2,7(0.34);Exp 5,1(0.05);Linear,9(0.43);Poly 2,4(0.2) 1.9877579863717656 43.59396946430206 1.5889767408370972 5.283818244934082 0.7989570004930723 1.912996768951416 184.19240867535885 267.9216294198793 115.98989274973063 178.292735821698 244.8925238099215 1445.5920476186502 UP 0.6190476190476191 0.38095238095238093 0.0 GO:0021817 7 nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration 1 1 1 1 1 1 1 1 58 0 2488 1.0 0.023165 0.023165 100.0 366669 syne2 SYNE2_9977 276.757 276.757 276.757 276.757 164.88 164.88 164.88 164.88 858.911 858.911 858.911 858.9109999999998 0.0 276.757 0.0 276.757 276.757 164.88 858.911 0 1 0 1 366669 SYNE2_9977 276.757 276.757 164.88 164.88 858.911 858.911 276.757 164.88 858.911 0 Linear,1(1) 1.748702883720398 1.748702883720398 1.748702883720398 1.748702883720398 0.0 1.748702883720398 276.757 276.757 164.88 164.88 858.911 858.911 DOWN 0.0 1.0 0.0 GO:0001815 10 positive regulation of antibody-dependent cellular cytotoxicity 1 1 1 1 1 1 1 1 58 0 2488 1.0 0.023165 0.023165 100.0 294228 rt1-s3 RT1-S3_9763 219.207 219.207 219.207 219.207 141.536 141.536 141.536 141.536 484.566 484.566 484.566 484.5659999999999 0.0 219.207 0.0 219.207 219.207 141.536 484.566 0 1 0 1 294228 RT1-S3_9763 219.207 219.207 141.536 141.536 484.566 484.566 219.207 141.536 484.566 0 Linear,1(1) 1.7851157188415527 1.7851157188415527 1.7851157188415527 1.7851157188415527 0.0 1.7851157188415527 219.207 219.207 141.536 141.536 484.566 484.566 DOWN 0.0 1.0 0.0 GO:0007420 5 brain development 75 79 5 5 5 4 4 4 55 75 2413 0.96578 0.10822 0.10822 5.06 360243;84487;24450;29182 top2a;slc17a6;hmgcs2;cdh22 TOP2A_10059;SLC17A6_32912;HMGCS2_8812;CDH22_32502 287.40425 288.259 203.468 69.55836708057966 320.8813568815441 73.79536352685503 162.67925 162.79199999999997 108.442 44.19592657983313 162.24708407972753 36.65633815103272 644.3240000000001 665.004 452.105 161.00455753797758 553.662691055885 154.24859846769058 2.5 338.3465 203.468;369.631;269.456;307.062 108.442;163.45;162.134;216.691 572.253;452.105;795.183;757.755 3 1 3 84487;24450;29182 SLC17A6_32912;HMGCS2_8812;CDH22_32502 315.383 307.062 50.6032304996432 180.75833333333333 163.45 31.12555805657673 668.3476666666667 757.755 188.20436222716341 369.631;269.456;307.062 163.45;162.134;216.691 452.105;795.183;757.755 1 360243 TOP2A_10059 203.468 203.468 108.442 108.442 572.253 572.253 203.468 108.442 572.253 0 Exp 2,2(0.5);Hill,1(0.25);Linear,1(0.25) 1.8853889810698339 7.560624122619629 1.7034999132156372 2.0807507038116455 0.15488267663346192 1.888186752796173 219.23705026103192 355.57144973896806 119.36724195176353 205.99125804823646 486.5395336127819 802.1084663872182 UP 0.75 0.25 0.0 GO:0008202 5 steroid metabolic process 95 104 7 7 6 5 5 5 54 99 2389 0.96877 0.09041 0.09041 4.81 286989;78968;24450;25086;25279 ugt2b7;srebf1;hmgcs2;cyp2e1;cyp24a1 UGT2B7_33032;SREBF1_32750;HMGCS2_8812;CYP2E1_8421;CYP24A1_32574 199.613534 189.111 4.13867 130.91547047477158 190.7878461095719 115.54034910240503 120.027136 127.579 1.39768 72.55608300061738 118.35001519170613 63.733962652440056 827.0919200000001 364.247 16.5686 1034.668959947882 712.9045312896595 977.7216586148992 4.13867;177.986;269.456;357.376;189.111 1.39768;117.256;162.134;191.769;127.579 16.5686;348.781;795.183;2610.68;364.247 4 1 4 286989;24450;25086;25279 UGT2B7_33032;HMGCS2_8812;CYP2E1_8421;CYP24A1_32574 205.0204175 229.2835 150.52215103307512 120.71992 144.85649999999998 83.76145041755343 946.6696499999999 579.715 1154.1494352233985 4.13867;269.456;357.376;189.111 1.39768;162.134;191.769;127.579 16.5686;795.183;2610.68;364.247 1 78968 SREBF1_32750 177.986 177.986 117.256 117.256 348.781 348.781 177.986 117.256 348.781 0 Exp 2,1(0.2);Hill,1(0.2);Linear,3(0.6) 2.1137579373872306 11.031176567077637 1.5889767408370972 3.570159435272217 0.7890942006847608 1.9080781936645508 84.86106461512132 314.3660033848787 56.42892516196502 183.62534683803497 -79.83541043176876 1734.0192504317688 UP 0.8 0.2 0.0 GO:0051939 7 gamma-aminobutyric acid import 1 1 1 1 1 1 1 1 58 0 2488 1.0 0.023165 0.023165 100.0 79212 slc6a1 SLC6A1_32594 145.445 145.445 145.445 145.445 104.722 104.722 104.722 104.722 237.101 237.101 237.101 237.101 0.0 145.445 0.0 145.445 145.445 104.722 237.101 1 0 1 79212 SLC6A1_32594 145.445 145.445 104.722 104.722 237.101 237.101 145.445 104.722 237.101 0 0 Linear,1(1) 2.0017645359039307 2.0017645359039307 2.0017645359039307 2.0017645359039307 0.0 2.0017645359039307 145.445 145.445 104.722 104.722 237.101 237.101 UP 1.0 0.0 0.0 GO:0098719 7 sodium ion import across plasma membrane 1 1 1 1 1 1 1 1 58 0 2488 1.0 0.023165 0.023165 100.0 79212 slc6a1 SLC6A1_32594 145.445 145.445 145.445 145.445 104.722 104.722 104.722 104.722 237.101 237.101 237.101 237.101 0.0 145.445 0.0 145.445 145.445 104.722 237.101 1 0 1 79212 SLC6A1_32594 145.445 145.445 104.722 104.722 237.101 237.101 145.445 104.722 237.101 0 0 Linear,1(1) 2.0017645359039307 2.0017645359039307 2.0017645359039307 2.0017645359039307 0.0 2.0017645359039307 145.445 145.445 104.722 104.722 237.101 237.101 UP 1.0 0.0 0.0 GO:0010629 7 negative regulation of gene expression 355 375 12 12 9 8 6 6 53 369 2119 0.21228 0.88648 0.45521 1.6 311715;78968;24494;24451;304729;316098 tcfl5;srebf1;il1b;hmox1;gli2;exosc7 TCFL5_9994;SREBF1_32750;IL1B_8892;HMOX1_8815;GLI2_8713;EXOSC7_8580 174.97959999999998 165.9885 61.2776 85.20545827210842 174.99501853538465 85.18014737849121 118.96640000000001 113.36 39.7754 70.01614780091805 118.00089506461539 65.00137914908267 382.0348333333333 343.824 140.784 236.0320561715436 387.31657924102564 256.50221414220374 270.921;177.986;153.991;61.2776;273.717;111.985 228.673;117.256;109.464;39.7754;163.744;54.886 338.867;348.781;258.668;140.784;831.582;373.527 4 2 4 311715;24494;24451;316098 TCFL5_9994;IL1B_8892;HMOX1_8815;EXOSC7_8580 149.54365 132.988 89.35656623414229 108.1996 82.175 85.71201764342422 277.9615 298.76750000000004 103.33142530872846 270.921;153.991;61.2776;111.985 228.673;109.464;39.7754;54.886 338.867;258.668;140.784;373.527 2 78968;304729 SREBF1_32750;GLI2_8713 225.8515 225.8515 67.69203926976942 140.5 140.5 32.8719800438003 590.1815 590.1815 341.3918610636464 177.986;273.717 117.256;163.744 348.781;831.582 0 Exp 2,2(0.34);Linear,2(0.34);Poly 2,2(0.34) 1.9601031955811412 12.020570874214172 1.5889767408370972 2.8712503910064697 0.4823093733920943 1.8848943710327148 106.80103395155461 243.1581660484454 62.94181361660368 174.99098638339632 193.1698538169952 570.8998128496714 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0034330 5 cell junction organization 75 80 5 5 5 4 4 4 55 76 2412 0.96413 0.11202 0.11202 5.0 84488;24232;298566;29650 fgf13;c3;c1qa;adam10 FGF13_32529;C3_8175;C1QA_8167;ADAM10_7983 234.82624999999996 239.1075 144.319 74.53346915033119 224.23501311134234 61.054197228287386 132.1209 145.9135 57.6936 53.59059764461172 128.88639699271593 48.10597165186427 699.36825 635.1015 153.26 518.8911831950735 579.2198502601457 360.57254490972 3.0 316.771 209.76;144.319;268.455;316.771 130.074;57.6936;161.753;178.963 483.266;153.26;786.937;1374.01 2 2 2 24232;298566 C3_8175;C1QA_8167 206.387 206.387 87.7774073893732 109.7233 109.7233 73.5811073862034 470.0985 470.0985 448.07730378194793 144.319;268.455 57.6936;161.753 153.26;786.937 2 84488;29650 FGF13_32529;ADAM10_7983 263.2655 263.2655 75.66820376155377 154.51850000000002 154.51850000000002 34.56974342542905 928.638 928.638 629.8511227012301 209.76;316.771 130.074;178.963 483.266;1374.01 0 Exp 2,1(0.25);Exp 5,1(0.25);Linear,2(0.5) 1.7566013401432448 7.050655961036682 1.6434866189956665 2.0174295902252197 0.17340828581025755 1.694869875907898 161.78345023267565 307.8690497673243 79.6021143082805 184.6396856917195 190.854890468828 1207.881609531172 CONFLICT 0.5 0.5 0.0 GO:0051310 5 metaphase plate congression 15 16 2 2 2 2 2 2 57 14 2474 0.99466 0.051414 0.051414 12.5 363198;500545 cenpq;cdca8 CENPQ_8290;CDCA8_33310 246.93475 246.93475 39.9715 292.6902350628135 214.17311585747032 288.99986913102066 118.19875 118.19875 12.1775 149.9366896497485 101.41591824685699 148.0462225786811 326.098 326.098 177.403 210.2864856570673 302.5600473015211 207.6351020794133 0.0 39.9715 0.5 246.93475 39.9715;453.898 12.1775;224.22 177.403;474.793 0 2 0 2 363198;500545 CENPQ_8290;CDCA8_33310 246.93475 246.93475 292.6902350628135 118.19875 118.19875 149.9366896497485 326.098 326.098 210.2864856570673 39.9715;453.898 12.1775;224.22 177.403;474.793 0 Exp 4,1(0.5);Power,1(0.5) 1.9427873872066204 3.8865761756896973 1.8991773128509521 1.9873988628387451 0.06238205624315639 1.9432880878448486 -158.71322000000004 652.5827200000001 -89.60289999999998 326.00039999999996 34.6558 617.5401999999999 DOWN 0.0 1.0 0.0 GO:0044419 2 interspecies interaction between organisms 272 296 18 18 16 13 12 12 47 284 2204 0.98466 0.035125 0.06011 4.05 29142;294228;362282;25211;24451;24450;304729;25086;245920;502902;24232;298566 vnn1;rt1-s3;pck1;lyz2;hmox1;hmgcs2;gli2;cyp2e1;cxcl10;clec7a;c3;c1qa VNN1_10157;RT1-S3_9763;PCK1_9439;LYZ2_32611;HMOX1_8815;HMGCS2_8812;GLI2_8713;CYP2E1_8421;CXCL10_8408;CLEC7A_32927;C3_8175;C1QA_8167 252.2648833333334 251.098 61.2776 94.33823603617908 259.0092311118772 98.24726387656531 156.72716666666665 155.1605 39.7754 73.58014125785613 163.4053551870367 80.03033877917036 822.6746666666668 531.679 140.784 747.7186924742039 829.147929512153 739.786554514066 233.741;219.207;227.854;214.715;61.2776;269.456;273.717;357.376;344.076;412.985;144.319;268.455 147.819;141.536;148.568;139.536;39.7754;162.134;163.744;191.769;187.725;338.673;57.6936;161.753 556.851;484.566;506.507;464.331;140.784;795.183;831.582;2610.68;2052.67;488.745;153.26;786.937 9 3 9 29142;362282;25211;24451;24450;25086;502902;24232;298566 VNN1_10157;PCK1_9439;LYZ2_32611;HMOX1_8815;HMGCS2_8812;CYP2E1_8421;CLEC7A_32927;C3_8175;C1QA_8167 243.35317777777774 233.741 104.40286514020804 154.19122222222222 148.568 85.33438402006801 722.5864444444445 506.507 744.3513512361131 233.741;227.854;214.715;61.2776;269.456;357.376;412.985;144.319;268.455 147.819;148.568;139.536;39.7754;162.134;191.769;338.673;57.6936;161.753 556.851;506.507;464.331;140.784;795.183;2610.68;488.745;153.26;786.937 3 294228;304729;245920 RT1-S3_9763;GLI2_8713;CXCL10_8408 279.0 273.717 62.6019117679324 164.335 163.744 23.100170800234235 1122.9393333333335 831.582 823.6530583135917 219.207;273.717;344.076 141.536;163.744;187.725 484.566;831.582;2052.67 0 Exp 2,1(0.09);Exp 5,1(0.09);Linear,8(0.67);Poly 2,2(0.17) 1.9219020878498596 23.260817885398865 1.5622447729110718 2.470346212387085 0.2664263910489343 1.9188846945762634 198.88800148237803 305.64176518428866 115.09528259167743 198.35905074165592 399.6129900561319 1245.7363432772013 UP 0.75 0.25 0.0 GO:0023056 5 positive regulation of signaling 428 452 14 13 10 8 6 6 53 446 2042 0.079357 0.96461 0.1657 1.33 29483;25247;24494;24408;25311;24232 slc1a3;nsg1;il1b;grin1;dcc;c3 SLC1A3_32817;NSG1_32675;IL1B_8892;GRIN1_32381;DCC_32537;C3_8175 229.40666666666667 232.335 144.319 71.31250018521762 228.11432700775435 72.19732157782141 160.19776666666667 174.94799999999998 57.6936 68.53696333225356 159.1233316525737 69.92642924679211 415.64300000000003 320.9925 153.26 298.78646907515736 397.49372473989797 288.12076619595155 303.435;216.472;153.991;310.025;248.198;144.319 189.179;166.237;109.464;254.954;183.659;57.6936 992.735;342.576;258.668;447.21;299.409;153.26 5 1 5 29483;25247;24494;24408;24232 SLC1A3_32817;NSG1_32675;IL1B_8892;GRIN1_32381;C3_8175 225.64840000000004 216.472 79.0626750799641 155.50552 166.237 75.54148090719434 438.88980000000004 342.576 327.930769829853 303.435;216.472;153.991;310.025;144.319 189.179;166.237;109.464;254.954;57.6936 992.735;342.576;258.668;447.21;153.26 1 25311 DCC_32537 248.198 248.198 183.659 183.659 299.409 299.409 248.198 183.659 299.409 0 Exp 2,3(0.5);Exp 5,1(0.17);Linear,1(0.17);Poly 2,1(0.17) 2.1749258465212464 13.561521053314209 1.6762725114822388 3.437419891357422 0.7225142071516703 1.9254007935523987 172.34478233960138 286.4685509937319 105.3567743632718 215.03875897006154 176.56403218121284 654.7219678187872 UP 0.8333333333333334 0.16666666666666666 0.0 GO:0040011 2 locomotion 209 224 10 10 9 7 7 7 52 217 2271 0.85822 0.25837 0.35462 3.12 366669;361680;24494;84488;25311;245920;24232 syne2;lsp1;il1b;fgf13;dcc;cxcl10;c3 SYNE2_9977;LSP1_32853;IL1B_8892;FGF13_32529;DCC_32537;CXCL10_8408;C3_8175 229.80514285714284 231.535 144.319 69.595339775564 235.10087696496 73.80344664457267 139.28537142857144 141.502 57.6936 45.838113153783326 143.0371006176634 46.641172976110816 669.5841428571429 483.266 153.26 653.6846743839693 730.2790152513098 734.6816969455747 276.757;231.535;153.991;209.76;248.198;344.076;144.319 164.88;141.502;109.464;130.074;183.659;187.725;57.6936 858.911;580.905;258.668;483.266;299.409;2052.67;153.26 2 5 2 24494;24232 IL1B_8892;C3_8175 149.155 149.155 6.839136787636285 83.5788 83.5788 36.607200904740054 205.964 205.964 74.5347115913116 153.991;144.319 109.464;57.6936 258.668;153.26 5 366669;361680;84488;25311;245920 SYNE2_9977;LSP1_32853;FGF13_32529;DCC_32537;CXCL10_8408 262.0652 248.198 51.965966263507596 161.568 164.88 25.385461715320414 855.0322 580.905 699.3611932862017 276.757;231.535;209.76;248.198;344.076 164.88;141.502;130.074;183.659;187.725 858.911;580.905;483.266;299.409;2052.67 0 Exp 2,2(0.29);Exp 5,1(0.15);Linear,3(0.43);Poly 2,1(0.15) 1.9799361928745032 14.145552158355713 1.6639630794525146 2.8712503910064697 0.4663584947163151 1.748702883720398 178.24819364969136 281.3620920645944 105.32802199603358 173.24272086110923 185.32775926036214 1153.8405264539235 DOWN 0.2857142857142857 0.7142857142857143 0.0 GO:0043254 6 regulation of protein-containing complex assembly 110 120 4 4 4 2 2 2 57 118 2370 0.46767 0.77635 1.0 1.67 25595;502902 map2;clec7a MAP2_32650;CLEC7A_32927 279.211 279.211 145.437 189.18500509289845 377.94312953773834 127.65147608189453 221.6955 221.6955 104.718 165.43116699249867 308.03094398015145 111.62371270478471 362.913 362.913 237.081 177.9533209805313 455.78352285191954 120.07296289515871 145.437;412.985 104.718;338.673 237.081;488.745 2 0 2 25595;502902 MAP2_32650;CLEC7A_32927 279.211 279.211 189.18500509289845 221.6955 221.6955 165.43116699249867 362.913 362.913 177.9533209805313 145.437;412.985 104.718;338.673 237.081;488.745 0 0 Linear,1(0.5);Poly 2,1(0.5) 2.1127078569712805 4.225494384765625 2.0998549461364746 2.1256394386291504 0.01823238949102467 2.1127471923828125 17.013959999999997 541.40804 -7.5803999999999405 450.9713999999999 116.28227999999999 609.54372 UP 1.0 0.0 0.0 GO:0065009 3 regulation of molecular function 643 686 16 16 13 9 8 8 51 678 1810 0.01048 0.99603 0.017312 1.17 313506;25595;24494;24451;24408;84488;502902;24232 stil;map2;il1b;hmox1;grin1;fgf13;clec7a;c3 STIL_33274;MAP2_32650;IL1B_8892;HMOX1_8815;GRIN1_32381;FGF13_32529;CLEC7A_32927;C3_8175 218.67882500000002 181.8755 61.2776 116.29580755968497 235.70705263897517 122.56486979075797 151.57425 119.769 39.7754 101.48592423626327 164.96049853795637 109.37346528311714 436.86300000000006 352.93899999999996 140.784 371.3986362137434 466.66593984271555 372.353726071781 311.636;145.437;153.991;61.2776;310.025;209.76;412.985;144.319 177.242;104.718;109.464;39.7754;254.954;130.074;338.673;57.6936 1285.89;237.081;258.668;140.784;447.21;483.266;488.745;153.26 6 2 6 25595;24494;24451;24408;502902;24232 MAP2_32650;IL1B_8892;HMOX1_8815;GRIN1_32381;CLEC7A_32927;C3_8175 204.67243333333332 149.714 130.21163398347582 150.87966666666668 107.09100000000001 119.14005280379334 287.62466666666666 247.8745 147.59814559494524 145.437;153.991;61.2776;310.025;412.985;144.319 104.718;109.464;39.7754;254.954;338.673;57.6936 237.081;258.668;140.784;447.21;488.745;153.26 2 313506;84488 STIL_33274;FGF13_32529 260.698 260.698 72.0372104401611 153.65800000000002 153.65800000000002 33.35281265500693 884.5780000000001 884.5780000000001 567.5408731430714 311.636;209.76 177.242;130.074 1285.89;483.266 0 Exp 2,2(0.25);Exp 5,1(0.13);Linear,3(0.38);Poly 2,2(0.25) 1.9186003967819252 15.630142092704773 1.5923793315887451 2.8712503910064697 0.42470174573535635 1.8213455080986023 138.08994193396137 299.26770806603867 81.24809248200296 221.90040751799705 179.49687569362982 694.2291243063703 UP 0.75 0.25 0.0 GO:0061024 5 membrane organization 110 116 4 4 3 3 2 2 57 114 2374 0.49096 0.7597 1.0 1.72 365377;366669 trim72;syne2 TRIM72_33144;SYNE2_9977 179.4249 179.4249 82.0928 137.6483758742543 146.71569501782454 129.64293733053117 107.0928 107.0928 49.3056 81.72344197156653 87.67296450743413 76.97051998371425 526.189 526.189 193.467 470.53996489990084 414.3751985914268 443.17401344971523 82.0928;276.757 49.3056;164.88 193.467;858.911 1 1 1 365377 TRIM72_33144 82.0928 82.0928 49.3056 49.3056 193.467 193.467 82.0928 49.3056 193.467 1 366669 SYNE2_9977 276.757 276.757 164.88 164.88 858.911 858.911 276.757 164.88 858.911 0 Linear,1(0.5);Poly 2,1(0.5) 1.7069088703504112 3.4148166179656982 1.6661137342453003 1.748702883720398 0.058399347646270944 1.7074083089828491 -11.34601600000002 370.195816 -6.170111999999989 220.35571199999998 -125.94611999999995 1178.3241199999998 CONFLICT 0.5 0.5 0.0 GO:0009612 4 response to mechanical stimulus 121 126 5 5 4 4 3 3 56 123 2365 0.66631 0.56613 0.76667 2.38 24494;304729;245920 il1b;gli2;cxcl10 IL1B_8892;GLI2_8713;CXCL10_8408 257.2613333333333 273.717 153.991 96.10498702113928 266.18067866918074 96.90773200178795 153.64433333333332 163.744 109.464 40.09611552673575 157.12143184721123 40.165770457854 1047.64 831.582 258.668 916.3086753512703 1153.6169892342316 947.7247665844195 153.991;273.717;344.076 109.464;163.744;187.725 258.668;831.582;2052.67 1 2 1 24494 IL1B_8892 153.991 153.991 109.464 109.464 258.668 258.668 153.991 109.464 258.668 2 304729;245920 GLI2_8713;CXCL10_8408 308.8965 308.8965 49.751326017504255 175.7345 175.7345 16.957127719634624 1442.126 1442.126 863.4396052255192 273.717;344.076 163.744;187.725 831.582;2052.67 0 Linear,3(1) 2.4982185501936516 7.539772272109985 2.1981756687164307 2.8712503910064697 0.3385829654757891 2.470346212387085 148.5083026841777 366.01436398248893 108.27130727140774 199.0173593952589 10.739121665302946 2084.5408783346975 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0071695 4 anatomical structure maturation 44 46 4 4 4 3 3 3 56 43 2445 0.97946 0.088879 0.088879 6.52 24408;24232;298566 grin1;c3;c1qa GRIN1_32381;C3_8175;C1QA_8167 240.933 268.455 144.319 86.21319488338199 246.13407473049512 78.37487611593484 158.13353333333333 161.753 57.6936 98.67999673821102 158.48089866617943 88.26577971070374 462.46900000000005 447.21 153.26 317.1139588428739 526.970581399598 325.72540616570944 1.5 289.24 310.025;144.319;268.455 254.954;57.6936;161.753 447.21;153.26;786.937 3 0 3 24408;24232;298566 GRIN1_32381;C3_8175;C1QA_8167 240.933 268.455 86.21319488338199 158.13353333333333 161.753 98.67999673821102 462.46900000000005 447.21 317.1139588428739 310.025;144.319;268.455 254.954;57.6936;161.753 447.21;153.26;786.937 0 0 Exp 2,1(0.34);Exp 5,1(0.34);Linear,1(0.34) 1.8827611545125937 5.660120606422424 1.7257766723632812 2.0174295902252197 0.148154395091576 1.9169143438339233 143.3735859037082 338.4924140962917 46.4666048796758 269.80046178699087 103.62077417662641 821.3172258233737 UP 1.0 0.0 0.0 GO:0071407 6 cellular response to organic cyclic compound 197 209 8 8 8 5 5 5 54 204 2284 0.64562 0.53946 0.81254 2.39 362282;24494;24450;304729;25315 pck1;il1b;hmgcs2;gli2;ephx1 PCK1_9439;IL1B_8892;HMGCS2_8812;GLI2_8713;EPHX1_8567 187.50548 227.854 12.5094 108.9990428400727 205.08678838984295 86.01860676500219 117.4384 148.568 3.282 67.46523542388331 130.04599955966532 49.01394532267188 490.66732 506.507 61.3966 334.402657509494 527.0502268017026 321.88664437767835 227.854;153.991;269.456;273.717;12.5094 148.568;109.464;162.134;163.744;3.282 506.507;258.668;795.183;831.582;61.3966 4 1 4 362282;24494;24450;25315 PCK1_9439;IL1B_8892;HMGCS2_8812;EPHX1_8567 165.95260000000002 190.9225 112.89026033323987 105.862 129.01600000000002 71.93972297231437 405.43865 382.5875 317.29167737707314 227.854;153.991;269.456;12.5094 148.568;109.464;162.134;3.282 506.507;258.668;795.183;61.3966 1 304729 GLI2_8713 273.717 273.717 163.744 163.744 831.582 831.582 273.717 163.744 831.582 0 Exp 2,1(0.2);Hill,1(0.2);Linear,3(0.6) 2.226650950740398 11.24173355102539 1.9080781936645508 2.8712503910064697 0.36579129438570207 2.162810802459717 91.96360644505683 283.0473535549432 58.30251380987468 176.57428619012535 197.55046697325878 783.7841730267412 UP 0.8 0.2 0.0 GO:1905952 5 regulation of lipid localization 57 62 5 5 5 4 4 4 55 58 2430 0.98676 0.053482 0.053482 6.45 78968;58827;24494;24232 srebf1;mest;il1b;c3 SREBF1_32750;MEST_9219;IL1B_8892;C3_8175 187.131 165.9885 144.319 58.47009884832876 175.99469598680597 49.32783004298156 120.81389999999999 113.36 57.6936 58.34962308967104 111.26659478345854 50.97826908640127 325.99925 303.72450000000003 153.26 165.43453360443416 298.4776195101093 145.89503334374092 2.5 225.107 177.986;272.228;153.991;144.319 117.256;198.842;109.464;57.6936 348.781;543.288;258.668;153.26 3 1 3 58827;24494;24232 MEST_9219;IL1B_8892;C3_8175 190.17933333333335 153.991 71.2206056723287 121.99986666666666 109.464 71.40433229470982 318.4053333333333 258.668 201.7594407737425 272.228;153.991;144.319 198.842;109.464;57.6936 543.288;258.668;153.26 1 78968 SREBF1_32750 177.986 177.986 117.256 117.256 348.781 348.781 177.986 117.256 348.781 0 Exp 2,2(0.5);Exp 5,1(0.25);Linear,1(0.25) 2.035537888634873 8.366440892219543 1.5889767408370972 2.8712503910064697 0.5779860458753348 1.9531068801879883 129.83030312863784 244.43169687136216 63.63126937212243 177.9965306278776 163.8734070676545 488.1250929323455 UP 0.75 0.25 0.0 GO:0031323 5 regulation of cellular metabolic process 979 1054 29 29 24 19 16 16 43 1038 1450 0.015577 0.99262 0.031499 1.52 360243;311715;313506;78968;291773;362282;25247;681410;24494;24451;24408;304729;84488;25311;502902;24232 top2a;tcfl5;stil;srebf1;taf4b;pck1;nsg1;loc681410;il1b;hmox1;grin1;gli2;fgf13;dcc;clec7a;c3 TOP2A_10059;TCFL5_9994;STIL_33274;SREBF1_32750;RGD1562997_32695;PCK1_9439;NSG1_32675;LOC681410_33126;IL1B_8892;HMOX1_8815;GRIN1_32381;GLI2_8713;FGF13_32529;DCC_32537;CLEC7A_32927;C3_8175 244.5689125 238.026 61.2776 92.2925094128581 244.80911767095876 97.82610795508577 169.8225 164.8945 39.7754 83.99230292954236 170.90508088408257 88.80864200313415 492.60025 465.238 140.784 295.23214955116254 482.9650064610731 306.5031584194999 203.468;270.921;311.636;177.986;279.902;227.854;216.472;410.591;153.991;61.2776;310.025;273.717;209.76;248.198;412.985;144.319 108.442;228.673;177.242;117.256;166.045;148.568;166.237;326.66;109.464;39.7754;254.954;163.744;130.074;183.659;338.673;57.6936 572.253;338.867;1285.89;348.781;888.462;506.507;342.576;495.344;258.668;140.784;447.21;831.582;483.266;299.409;488.745;153.26 9 7 9 311715;362282;25247;681410;24494;24451;24408;502902;24232 TCFL5_9994;PCK1_9439;NSG1_32675;LOC681410_33126;IL1B_8892;HMOX1_8815;GRIN1_32381;CLEC7A_32927;C3_8175 245.38173333333336 227.854 119.27868160987519 185.63311111111113 166.237 109.06555604429433 352.44011111111115 342.576 143.72901897967952 270.921;227.854;216.472;410.591;153.991;61.2776;310.025;412.985;144.319 228.673;148.568;166.237;326.66;109.464;39.7754;254.954;338.673;57.6936 338.867;506.507;342.576;495.344;258.668;140.784;447.21;488.745;153.26 7 360243;313506;78968;291773;304729;84488;25311 TOP2A_10059;STIL_33274;SREBF1_32750;RGD1562997_32695;GLI2_8713;FGF13_32529;DCC_32537 243.52385714285714 248.198 48.19368428341558 149.49457142857142 163.744 30.320203868362224 672.8061428571428 572.253 350.7238128049993 203.468;311.636;177.986;279.902;273.717;209.76;248.198 108.442;177.242;117.256;166.045;163.744;130.074;183.659 572.253;1285.89;348.781;888.462;831.582;483.266;299.409 0 Exp 2,7(0.44);Exp 5,1(0.07);Linear,4(0.25);Poly 2,4(0.25) 1.9595414929931383 32.12206566333771 1.5889767408370972 3.437419891357422 0.5034054350073183 1.8807859420776367 199.34558288769955 289.79224211230047 128.66627156452427 210.97872843547572 347.93649671993035 637.2640032800697 CONFLICT 0.5625 0.4375 0.0 GO:0009117 6 nucleotide metabolic process 89 101 3 2 2 2 2 2 57 99 2389 0.58282 0.68777 1.0 1.98 362282;24450 pck1;hmgcs2 PCK1_9439;HMGCS2_8812 248.65500000000003 248.65500000000003 227.854 29.417056310922636 248.2171623260792 29.41053889922133 155.351 155.351 148.568 9.592610593576623 155.20822547270782 9.590485330195891 650.845 650.845 506.507 204.1247571658077 647.8068473064574 204.07953288956105 227.854;269.456 148.568;162.134 506.507;795.183 2 0 2 362282;24450 PCK1_9439;HMGCS2_8812 248.65500000000003 248.65500000000003 29.417056310922636 155.351 155.351 9.592610593576623 650.845 650.845 204.1247571658077 227.854;269.456 148.568;162.134 506.507;795.183 0 0 Exp 2,1(0.5);Linear,1(0.5) 2.031455667543723 4.070888996124268 1.9080781936645508 2.162810802459717 0.18012315506840187 2.035444498062134 207.88504000000003 289.42496000000006 142.05632000000003 168.64567999999997 367.94252000000006 933.74748 UP 1.0 0.0 0.0 GO:0042127 5 regulation of cell population proliferation 436 466 17 17 15 11 10 10 49 456 2032 0.47382 0.65986 1.0 2.15 311715;294228;291773;24494;24451;304729;245920;502902;29650;170924 tcfl5;rt1-s3;taf4b;il1b;hmox1;gli2;cxcl10;clec7a;adam10;abcc4 TCFL5_9994;RT1-S3_9763;RGD1562997_32695;IL1B_8892;HMOX1_8815;GLI2_8713;CXCL10_8408;CLEC7A_32927;ADAM10_7983;ABCC4_32768 257.74996000000004 272.31899999999996 61.2776 98.30629451517774 257.8211324511549 105.26991569149759 170.69534 164.8945 39.7754 77.51856874180676 173.41178892487184 85.65943310236541 747.7506000000001 553.9485 140.784 582.0964557545806 725.751989212259 624.4887888661351 270.921;219.207;279.902;153.991;61.2776;273.717;344.076;412.985;316.771;244.652 228.673;141.536;166.045;109.464;39.7754;163.744;187.725;338.673;178.963;152.355 338.867;484.566;888.462;258.668;140.784;831.582;2052.67;488.745;1374.01;619.152 5 5 5 311715;24494;24451;502902;170924 TCFL5_9994;IL1B_8892;HMOX1_8815;CLEC7A_32927;ABCC4_32768 228.76531999999997 244.652 131.91826421997837 173.78807999999998 152.355 114.84310370427997 369.2432 338.867 188.4663650142911 270.921;153.991;61.2776;412.985;244.652 228.673;109.464;39.7754;338.673;152.355 338.867;258.668;140.784;488.745;619.152 5 294228;291773;304729;245920;29650 RT1-S3_9763;RGD1562997_32695;GLI2_8713;CXCL10_8408;ADAM10_7983 286.7346 279.902 47.34538143578533 167.6026 166.045 17.541039145387252 1126.258 888.462 607.2004925689702 219.207;279.902;273.717;344.076;316.771 141.536;166.045;163.744;187.725;178.963 484.566;888.462;831.582;2052.67;1374.01 0 Exp 2,1(0.1);Linear,7(0.7);Poly 2,2(0.2) 1.9287650496611473 19.684994339942932 1.5415009260177612 2.8712503910064697 0.43770723364395 1.8148866295814514 196.81908739614107 318.6808326038589 122.64883331663327 218.7418466833667 386.96347885320336 1108.5377211467967 CONFLICT 0.5 0.5 0.0 GO:2001056 9 positive regulation of cysteine-type endopeptidase activity 48 51 2 2 2 2 2 2 57 49 2439 0.88741 0.33198 0.33198 3.92 24408;502902 grin1;clec7a GRIN1_32381;CLEC7A_32927 361.505 361.505 310.025 72.80371419096703 372.3214633148468 71.17857151360343 296.8135 296.8135 254.954 59.19827261415673 305.6085999636331 57.87683399910012 467.97749999999996 467.97749999999996 447.21 29.369680156584604 472.3409596326939 28.7140828265114 310.025;412.985 254.954;338.673 447.21;488.745 2 0 2 24408;502902 GRIN1_32381;CLEC7A_32927 361.505 361.505 72.80371419096703 296.8135 296.8135 59.19827261415673 467.97749999999996 467.97749999999996 29.369680156584604 310.025;412.985 254.954;338.673 447.21;488.745 0 0 Exp 2,1(0.5);Poly 2,1(0.5) 2.0063005921894206 4.016769289970398 1.9169143438339233 2.0998549461364746 0.12935854044248532 2.008384644985199 260.6042 462.4058 214.76888 378.85812 427.2732 508.68179999999995 UP 1.0 0.0 0.0 GO:0043066 8 negative regulation of apoptotic process 279 296 10 10 8 8 7 7 52 289 2199 0.6221 0.53821 0.83945 2.36 29142;313506;24567;24494;24451;24408;304729 vnn1;stil;mt1;il1b;hmox1;grin1;gli2 VNN1_10157;STIL_33274;MT1A_9255;IL1B_8892;HMOX1_8815;GRIN1_32381;GLI2_8713 248.16294285714284 273.717 61.2776 110.61759669399886 248.01186315687102 114.25187470972729 157.7704857142857 163.744 39.7754 69.63049572027646 157.04390466495934 71.08470217562035 1447.3535714285713 556.851 140.784 2308.5566312819687 1501.1016945570072 2358.7088103879773 233.741;311.636;392.753;153.991;61.2776;310.025;273.717 147.819;177.242;211.395;109.464;39.7754;254.954;163.744 556.851;1285.89;6610.49;258.668;140.784;447.21;831.582 5 2 5 29142;24567;24494;24451;24408 VNN1_10157;MT1A_9255;IL1B_8892;HMOX1_8815;GRIN1_32381 230.35751999999997 233.741 129.56707910866868 152.68148000000002 147.819 84.47798968993045 1602.8006 447.21 2804.038975856042 233.741;392.753;153.991;61.2776;310.025 147.819;211.395;109.464;39.7754;254.954 556.851;6610.49;258.668;140.784;447.21 2 313506;304729 STIL_33274;GLI2_8713 292.67650000000003 292.67650000000003 26.812782035812145 170.493 170.493 9.544527332455957 1058.736 1058.736 321.2442675472976 311.636;273.717 177.242;163.744 1285.89;831.582 0 Exp 2,2(0.29);Linear,4(0.58);Poly 2,1(0.15) 1.9726391345753655 14.055771589279175 1.5923793315887451 2.8712503910064697 0.4315026028425809 1.9169143438339233 166.2162804427536 330.10960527153213 106.1874926185261 209.35347881004532 -262.84911405814296 3157.556256915286 UP 0.7142857142857143 0.2857142857142857 0.0 GO:0042737 5 drug catabolic process 55 60 3 3 3 2 2 2 57 58 2430 0.83953 0.40777 0.64877 3.33 362282;25086 pck1;cyp2e1 PCK1_9439;CYP2E1_8421 292.615 292.615 227.854 91.58588451284383 321.903084784689 81.68470126828983 170.1685 170.1685 148.568 30.547720054040145 179.93730028708137 27.245261650463735 1558.5935 1558.5935 506.507 1487.874997089641 2034.3983611483256 1327.0235397986517 227.854;357.376 148.568;191.769 506.507;2610.68 2 0 2 362282;25086 PCK1_9439;CYP2E1_8421 292.615 292.615 91.58588451284383 170.1685 170.1685 30.547720054040145 1558.5935 1558.5935 1487.874997089641 227.854;357.376 148.568;191.769 506.507;2610.68 0 0 Exp 2,1(0.5);Linear,1(0.5) 1.9779637075151246 3.971725583076477 1.8089147806167603 2.162810802459717 0.2502422768800971 1.9858627915382385 165.68344000000008 419.54655999999994 127.83152000000001 212.50547999999998 -503.49603999999954 3620.6830399999994 UP 1.0 0.0 0.0 GO:0006996 5 organelle organization 397 425 14 14 10 12 9 9 50 416 2072 0.46649 0.67172 0.86133 2.12 246118;360243;313506;316273;25595;24503;84488;500545;170924 tubb3;top2a;stil;mcm3;map2;ina;fgf13;cdca8;abcc4 TUBB3_32820;TOP2A_10059;STIL_33274;MCM3_9207;MAP2_32650;INA_32322;FGF13_32529;CDCA8_33310;ABCC4_32768 265.0954444444444 244.652 145.437 88.4899195899047 278.81829344395913 81.88010923139576 168.66144444444444 152.355 104.718 56.107925396309035 179.31896537022715 53.801386079762665 566.7158888888889 483.266 237.081 296.4788462750946 574.1036565236473 275.75137744253334 282.273;203.468;311.636;229.093;145.437;305.642;209.76;453.898;244.652 238.208;108.442;177.242;133.518;104.718;249.176;130.074;224.22;152.355 354.06;572.253;1285.89;614.889;237.081;459.059;483.266;474.793;619.152 4 5 4 246118;25595;24503;170924 TUBB3_32820;MAP2_32650;INA_32322;ABCC4_32768 244.50100000000003 263.4625 70.66032541202537 186.11424999999997 195.2815 69.41560721900616 417.338 406.5595 162.24079200373737 282.273;145.437;305.642;244.652 238.208;104.718;249.176;152.355 354.06;237.081;459.059;619.152 5 360243;313506;316273;84488;500545 TOP2A_10059;STIL_33274;MCM3_9207;FGF13_32529;CDCA8_33310 281.571 229.093 105.6069812654448 154.6992 133.518 46.195486047881396 686.2182 572.253 340.4307565345704 203.468;311.636;229.093;209.76;453.898 108.442;177.242;133.518;130.074;224.22 572.253;1285.89;614.889;483.266;474.793 0 Exp 2,5(0.56);Linear,3(0.34);Power,1(0.12) 1.8824809781053455 17.140034317970276 1.5415009260177612 2.545419454574585 0.31645630132063424 1.8518693447113037 207.28203031237348 322.90885857651546 132.0042665188559 205.31862237003298 373.01637598916057 760.4154017886173 CONFLICT 0.4444444444444444 0.5555555555555556 0.0 GO:0060341 5 regulation of cellular localization 248 267 8 8 8 7 7 7 52 260 2228 0.72648 0.42505 0.66781 2.62 78968;25595;24451;24408;245920;363198;29650 srebf1;map2;hmox1;grin1;cxcl10;cenpq;adam10 SREBF1_32750;MAP2_32650;HMOX1_8815;GRIN1_32381;CXCL10_8408;CENPQ_8290;ADAM10_7983 199.36344285714287 177.986 39.9715 125.70520185871196 181.20433778459127 138.47675299538838 127.93841428571429 117.256 12.1775 85.7685948466459 113.39883913497292 95.47492597844582 682.5627142857144 348.781 140.784 738.157495181463 686.9858489790591 815.2987979511788 177.986;145.437;61.2776;310.025;344.076;39.9715;316.771 117.256;104.718;39.7754;254.954;187.725;12.1775;178.963 348.781;237.081;140.784;447.21;2052.67;177.403;1374.01 3 4 3 25595;24451;24408 MAP2_32650;HMOX1_8815;GRIN1_32381 172.24653333333333 145.437 126.52225321995071 133.14913333333334 104.718 110.37075917766143 275.02500000000003 237.081 156.69726775218504 145.437;61.2776;310.025 104.718;39.7754;254.954 237.081;140.784;447.21 4 78968;245920;363198;29650 SREBF1_32750;CXCL10_8408;CENPQ_8290;ADAM10_7983 219.701125 247.3785 140.1600988396098 124.03037499999999 148.1095 80.89407960555066 988.216 861.3955 884.7210801049108 177.986;344.076;39.9715;316.771 117.256;187.725;12.1775;178.963 348.781;2052.67;177.403;1374.01 0 Exp 2,2(0.29);Exp 4,1(0.15);Linear,3(0.43);Poly 2,1(0.15) 1.8684349565684484 13.23691999912262 1.5889767408370972 2.470346212387085 0.32483107075548423 1.8991773128509521 106.23972612205154 292.4871595922342 64.40015005188359 191.47667851954498 135.72798930413148 1229.3974392672972 CONFLICT 0.42857142857142855 0.5714285714285714 0.0 GO:0051046 6 regulation of secretion 220 238 8 8 7 6 5 5 54 233 2255 0.5215 0.6588 1.0 2.1 78968;79212;294228;24494;24451 srebf1;slc6a1;rt1-s3;il1b;hmox1 SREBF1_32750;SLC6A1_32594;RT1-S3_9763;IL1B_8892;HMOX1_8815 151.58132 153.991 61.2776 58.02728355706474 159.6991990753554 56.28593600285136 102.55068000000001 109.464 39.7754 37.846221789129714 107.99292430494403 35.693424434583974 293.98 258.668 140.784 129.68938410486803 311.6652757894075 136.32062034801362 177.986;145.445;219.207;153.991;61.2776 117.256;104.722;141.536;109.464;39.7754 348.781;237.101;484.566;258.668;140.784 3 2 3 79212;24494;24451 SLC6A1_32594;IL1B_8892;HMOX1_8815 120.23786666666668 145.445 51.239567846082856 84.6538 104.722 38.93808843433378 212.18433333333334 237.101 62.76774308777837 145.445;153.991;61.2776 104.722;109.464;39.7754 237.101;258.668;140.784 2 78968;294228 SREBF1_32750;RT1-S3_9763 198.5965 198.5965 29.147648627290792 129.39600000000002 129.39600000000002 17.168552647209175 416.6735 416.6735 96.01449428341554 177.986;219.207 117.256;141.536 348.781;484.566 0 Exp 2,1(0.2);Linear,3(0.6);Poly 2,1(0.2) 1.9180631464089364 9.839486718177795 1.5889767408370972 2.8712503910064697 0.5327282228926705 1.7851157188415527 100.71816337136498 202.44447662863502 69.37700395208509 135.7243560479149 180.30224270312232 407.6577572968777 UP 0.6 0.4 0.0 GO:2000026 5 regulation of multicellular organismal development 487 514 19 19 17 13 12 12 47 502 1986 0.58886 0.54069 1.0 2.33 29142;338475;25595;24494;24451;24408;304729;84488;25311;245920;24232;29650 vnn1;nrep;map2;il1b;hmox1;grin1;gli2;fgf13;dcc;cxcl10;c3;adam10 VNN1_10157;NREP_9364;MAP2_32650;IL1B_8892;HMOX1_8815;GRIN1_32381;GLI2_8713;FGF13_32529;DCC_32537;CXCL10_8408;C3_8175;ADAM10_7983 221.94488333333337 227.88350000000003 61.2776 84.0098769683425 225.13856484129303 87.81694746050174 141.7805 145.298 39.7754 59.24219279297489 143.74058296783932 62.60372638552334 611.0443333333334 465.238 140.784 568.8766522797096 643.0799492850854 645.0396648057113 233.741;222.026;145.437;153.991;61.2776;310.025;273.717;209.76;248.198;344.076;144.319;316.771 147.819;142.777;104.718;109.464;39.7754;254.954;163.744;130.074;183.659;187.725;57.6936;178.963 556.851;497.741;237.081;258.668;140.784;447.21;831.582;483.266;299.409;2052.67;153.26;1374.01 6 6 6 29142;25595;24494;24451;24408;24232 VNN1_10157;MAP2_32650;IL1B_8892;HMOX1_8815;GRIN1_32381;C3_8175 174.7984333333333 149.714 85.87370843748789 119.07066666666667 107.09100000000001 76.99859435139491 298.97566666666665 247.8745 167.44337657210173 233.741;145.437;153.991;61.2776;310.025;144.319 147.819;104.718;109.464;39.7754;254.954;57.6936 556.851;237.081;258.668;140.784;447.21;153.26 6 338475;304729;84488;25311;245920;29650 NREP_9364;GLI2_8713;FGF13_32529;DCC_32537;CXCL10_8408;ADAM10_7983 269.09133333333335 260.9575 53.083578883367366 164.49033333333333 171.3535 23.551031634870277 923.1129999999999 664.6614999999999 670.9692163174104 222.026;273.717;209.76;248.198;344.076;316.771 142.777;163.744;130.074;183.659;187.725;178.963 497.741;831.582;483.266;299.409;2052.67;1374.01 0 Exp 2,2(0.17);Exp 5,1(0.09);Linear,7(0.59);Poly 2,2(0.17) 1.933782422208242 23.606295943260193 1.5347857475280762 2.8712503910064697 0.39731624198795823 1.9233027696609497 174.4118207527186 269.4779459139481 108.26107396272045 175.2999260372796 289.1720667705376 932.9165998961291 CONFLICT 0.5 0.5 0.0 GO:0006357 8 regulation of transcription by RNA polymerase II 343 364 12 12 10 10 9 9 50 355 2133 0.66913 0.47253 0.85023 2.47 360243;311715;78968;291773;362282;24494;24451;24408;304729 top2a;tcfl5;srebf1;taf4b;pck1;il1b;hmox1;grin1;gli2 TOP2A_10059;TCFL5_9994;SREBF1_32750;RGD1562997_32695;PCK1_9439;IL1B_8892;HMOX1_8815;GRIN1_32381;GLI2_8713 217.6824 227.854 61.2776 78.08091156768083 208.57790425864124 84.78406684100732 148.5468222222222 148.568 39.7754 65.40836561583271 144.1084214922083 69.9355939840235 481.4571111111111 447.21 140.784 250.47772338595533 448.00594963720425 252.22383598330356 203.468;270.921;177.986;279.902;227.854;153.991;61.2776;310.025;273.717 108.442;228.673;117.256;166.045;148.568;109.464;39.7754;254.954;163.744 572.253;338.867;348.781;888.462;506.507;258.668;140.784;447.21;831.582 5 4 5 311715;362282;24494;24451;24408 TCFL5_9994;PCK1_9439;IL1B_8892;HMOX1_8815;GRIN1_32381 204.81372000000002 227.854 98.93938425062082 156.28688000000002 148.568 87.75226365953185 338.4072 338.867 146.2096719259708 270.921;227.854;153.991;61.2776;310.025 228.673;148.568;109.464;39.7754;254.954 338.867;506.507;258.668;140.784;447.21 4 360243;78968;291773;304729 TOP2A_10059;SREBF1_32750;RGD1562997_32695;GLI2_8713 233.76824999999997 238.59249999999997 50.839584579833144 138.87175 140.5 30.27774027648035 660.2695 701.9175 249.12632646711597 203.468;177.986;279.902;273.717 108.442;117.256;166.045;163.744 572.253;348.781;888.462;831.582 0 Exp 2,5(0.56);Linear,3(0.34);Poly 2,1(0.12) 1.9545537942627562 17.894142508506775 1.5889767408370972 2.8712503910064697 0.40729944940219415 1.9169143438339233 166.66953777578183 268.69526222421814 105.81335668654484 191.28028775789957 317.8116651656204 645.1025570566019 CONFLICT 0.5555555555555556 0.4444444444444444 0.0 GO:0052695 9 cellular glucuronidation 3 10 1 1 1 1 1 1 58 9 2479 0.97893 0.20926 0.20926 10.0 286989 ugt2b7 UGT2B7_33032 4.13867 4.13867 4.13867 4.13867 1.39768 1.39768 1.39768 1.39768 16.5686 16.5686 16.5686 16.5686 0.0 4.13867 0.0 4.13867 4.13867 1.39768 16.5686 1 0 1 286989 UGT2B7_33032 4.13867 4.13867 1.39768 1.39768 16.5686 16.5686 4.13867 1.39768 16.5686 0 0 Hill,1(1) 3.570159435272217 3.570159435272217 3.570159435272217 3.570159435272217 0.0 3.570159435272217 4.13867 4.13867 1.39768 1.39768 16.5686 16.5686 UP 1.0 0.0 0.0 GO:0031103 7 axon regeneration 17 18 3 3 2 2 1 1 58 17 2471 0.93634 0.34512 0.34512 5.56 338475 nrep NREP_9364 222.026 222.026 222.026 222.026 142.777 142.777 142.777 142.777 497.741 497.741 497.741 497.741 0.0 222.026 222.026 142.777 497.741 0 1 0 1 338475 NREP_9364 222.026 222.026 142.777 142.777 497.741 497.741 222.026 142.777 497.741 0 Linear,1(1) 1.5347857475280762 1.5347857475280762 1.5347857475280762 1.5347857475280762 0.0 1.5347857475280762 222.026 222.026 142.777 142.777 497.741 497.741 DOWN 0.0 1.0 0.0 GO:0045927 5 positive regulation of growth 71 75 3 3 3 2 2 2 57 73 2415 0.74935 0.52421 0.69215 2.67 24232;29650 c3;adam10 C3_8175;ADAM10_7983 230.54500000000002 230.54500000000002 144.319 121.94197862918249 178.48934716157206 97.21246919572687 118.3283 118.3283 57.6936 85.7504150904239 81.72241670305677 68.36045863129611 763.635 763.635 153.26 863.2006031334779 395.1444159388646 688.1458131577687 144.319;316.771 57.6936;178.963 153.26;1374.01 1 1 1 24232 C3_8175 144.319 144.319 57.6936 57.6936 153.26 153.26 144.319 57.6936 153.26 1 29650 ADAM10_7983 316.771 316.771 178.963 178.963 1374.01 1374.01 316.771 178.963 1374.01 0 Exp 5,1(0.5);Linear,1(0.5) 1.684129112747571 3.3692632913589478 1.6434866189956665 1.7257766723632812 0.05818785476044328 1.6846316456794739 61.542039999999986 399.54796000000005 -0.5157119999999793 237.17231199999998 -432.6999999999998 1959.9699999999998 CONFLICT 0.5 0.5 0.0 GO:0006468 7 protein phosphorylation 190 202 5 4 4 3 3 3 56 199 2289 0.29889 0.85974 0.62354 1.49 24494;84488;29650 il1b;fgf13;adam10 IL1B_8892;FGF13_32529;ADAM10_7983 226.84066666666664 209.76 153.991 82.72329768773344 196.58151306649026 56.52497158710793 139.50033333333332 130.074 109.464 35.69551190742801 126.04509254052267 23.647482811352102 705.3146666666667 483.266 258.668 589.895034745448 471.59993235196816 371.39630723837047 153.991;209.76;316.771 109.464;130.074;178.963 258.668;483.266;1374.01 1 2 1 24494 IL1B_8892 153.991 153.991 109.464 109.464 258.668 258.668 153.991 109.464 258.668 2 84488;29650 FGF13_32529;ADAM10_7983 263.2655 263.2655 75.66820376155377 154.51850000000002 154.51850000000002 34.56974342542905 928.638 928.638 629.8511227012301 209.76;316.771 130.074;178.963 483.266;1374.01 0 Exp 2,1(0.34);Linear,2(0.67) 1.9875907878945527 6.178700089454651 1.6434866189956665 2.8712503910064697 0.7030132547273692 1.6639630794525146 133.23044301766464 320.4508903156687 99.10705905244788 179.8936076142188 37.78559474300687 1372.8437385903264 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0018960 5 4-nitrophenol metabolic process 1 1 1 1 1 1 1 1 58 0 2488 1.0 0.023165 0.023165 100.0 25086 cyp2e1 CYP2E1_8421 357.376 357.376 357.376 357.376 191.769 191.769 191.769 191.76900000000003 2610.68 2610.68 2610.68 2610.68 0.0 357.376 0.0 357.376 357.376 191.769 2610.68 1 0 1 25086 CYP2E1_8421 357.376 357.376 191.769 191.769 2610.68 2610.68 357.376 191.769 2610.68 0 0 Linear,1(1) 1.8089147806167603 1.8089147806167603 1.8089147806167603 1.8089147806167603 0.0 1.8089147806167603 357.376 357.376 191.769 191.769 2610.68 2610.68 UP 1.0 0.0 0.0 GO:0030324 5 lung development 38 42 3 3 3 3 3 3 56 39 2449 0.98491 0.071664 0.071664 7.14 78968;24450;304729 srebf1;hmgcs2;gli2 SREBF1_32750;HMGCS2_8812;GLI2_8713 240.38633333333334 269.456 177.986 54.082254301511234 232.79580508474575 57.35525715722813 147.71133333333333 162.134 117.256 26.38737427887302 143.9308996088657 27.909154018013293 658.5153333333333 795.183 348.781 268.85449546982375 623.2987855280312 287.49266833194383 1.5 271.5865 177.986;269.456;273.717 117.256;162.134;163.744 348.781;795.183;831.582 1 2 1 24450 HMGCS2_8812 269.456 269.456 162.134 162.134 795.183 795.183 269.456 162.134 795.183 2 78968;304729 SREBF1_32750;GLI2_8713 225.8515 225.8515 67.69203926976942 140.5 140.5 32.8719800438003 590.1815 590.1815 341.3918610636464 177.986;273.717 117.256;163.744 348.781;831.582 0 Exp 2,1(0.34);Linear,2(0.67) 1.8818804688164477 5.695230603218079 1.5889767408370972 2.1981756687164307 0.30471451555989176 1.9080781936645508 179.18650133778908 301.5861653288776 117.85120835282835 177.57145831383832 354.2778312819398 962.7528353847267 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0001975 5 response to amphetamine 19 21 2 2 2 2 2 2 57 19 2469 0.98833 0.083624 0.083624 9.52 24408;25311 grin1;dcc GRIN1_32381;DCC_32537 279.1115 279.1115 248.198 43.718290960420795 274.1875962841107 43.160158814505 219.3065 219.3065 183.659 50.41317796469505 213.62856454422297 49.76957514807678 373.30949999999996 373.30949999999996 299.409 104.51108936615302 361.53862492742405 103.17684236567621 0.5 279.1115 310.025;248.198 254.954;183.659 447.21;299.409 1 1 1 24408 GRIN1_32381 310.025 310.025 254.954 254.954 447.21 447.21 310.025 254.954 447.21 1 25311 DCC_32537 248.198 248.198 183.659 183.659 299.409 299.409 248.198 183.659 299.409 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.9253820909064732 3.8508015871047974 1.9169143438339233 1.933887243270874 0.012001652288265163 1.9254007935523987 218.52104000000003 339.70195999999993 149.4374 289.17560000000003 228.46452 518.1544799999999 CONFLICT 0.5 0.5 0.0 GO:0022607 5 cellular component assembly 355 395 15 15 11 11 8 8 51 387 2101 0.42171 0.71683 0.85547 2.03 365377;313506;25247;316273;24408;84488;29650;170924 trim72;stil;nsg1;mcm3;grin1;fgf13;adam10;abcc4 TRIM72_33144;STIL_33274;NSG1_32675;MCM3_9207;GRIN1_32381;FGF13_32529;ADAM10_7983;ABCC4_32768 240.06272499999997 236.8725 82.0928 77.89396092072417 219.88759454393892 82.60221188601444 155.331075 159.296 49.3056 57.874508759550494 140.23036148425066 61.75735170270867 670.0575 549.0775 193.467 430.84110990612646 583.7474961226603 362.2612549077847 82.0928;311.636;216.472;229.093;310.025;209.76;316.771;244.652 49.3056;177.242;166.237;133.518;254.954;130.074;178.963;152.355 193.467;1285.89;342.576;614.889;447.21;483.266;1374.01;619.152 4 4 4 365377;25247;24408;170924 TRIM72_33144;NSG1_32675;GRIN1_32381;ABCC4_32768 213.31044999999997 230.562 95.85416702475698 155.7129 159.296 84.24832658223347 400.60125 394.89300000000003 179.0794358776296 82.0928;216.472;310.025;244.652 49.3056;166.237;254.954;152.355 193.467;342.576;447.21;619.152 4 313506;316273;84488;29650 STIL_33274;MCM3_9207;FGF13_32529;ADAM10_7983 266.815 270.3645 55.325540473335366 154.94924999999998 155.38 26.781233670551316 939.5137500000001 950.3895 455.4509616928224 311.636;229.093;209.76;316.771 177.242;133.518;130.074;178.963 1285.89;614.889;483.266;1374.01 0 Exp 2,4(0.5);Linear,3(0.38);Poly 2,1(0.13) 1.854787181434783 15.355631828308105 1.5415009260177612 3.437419891357422 0.6254751766284238 1.6650384068489075 186.08496397908658 294.0404860209134 115.22608655031596 195.43606344968399 371.49984298001067 968.6151570199893 CONFLICT 0.5 0.5 0.0 GO:1901700 4 response to oxygen-containing compound 599 638 25 25 22 17 15 15 44 623 1865 0.5956 0.5241 1.0 2.35 78968;79212;362282;24567;58827;25595;681410;24494;24451;24450;24408;25086;25279;245920;24232 srebf1;slc6a1;pck1;mt1;mest;map2;loc681410;il1b;hmox1;hmgcs2;grin1;cyp2e1;cyp24a1;cxcl10;c3 SREBF1_32750;SLC6A1_32594;PCK1_9439;MT1A_9255;MEST_9219;MAP2_32650;LOC681410_33126;IL1B_8892;HMOX1_8815;HMGCS2_8812;GRIN1_32381;CYP2E1_8421;CYP24A1_32574;CXCL10_8408;C3_8175 240.12837333333337 227.854 61.2776 105.83447984000733 230.02895016297205 106.28522338711689 156.217 148.568 39.7754 75.1687894689203 147.41986551942534 70.57495133207406 1053.4196 447.21 140.784 1694.289681096215 1089.2802277593262 1757.0156606431376 177.986;145.445;227.854;392.753;272.228;145.437;410.591;153.991;61.2776;269.456;310.025;357.376;189.111;344.076;144.319 117.256;104.722;148.568;211.395;198.842;104.718;326.66;109.464;39.7754;162.134;254.954;191.769;127.579;187.725;57.6936 348.781;237.101;506.507;6610.49;543.288;237.081;495.344;258.668;140.784;795.183;447.21;2610.68;364.247;2052.67;153.26 13 2 13 79212;362282;24567;58827;25595;681410;24494;24451;24450;24408;25086;25279;24232 SLC6A1_32594;PCK1_9439;MT1A_9255;MEST_9219;MAP2_32650;LOC681410_33126;IL1B_8892;HMOX1_8815;HMGCS2_8812;GRIN1_32381;CYP2E1_8421;CYP24A1_32574;C3_8175 236.91258461538467 227.854 108.78568349700117 156.7903076923077 148.568 79.89048248273448 1030.7571538461539 447.21 1795.5257304849854 145.445;227.854;392.753;272.228;145.437;410.591;153.991;61.2776;269.456;310.025;357.376;189.111;144.319 104.722;148.568;211.395;198.842;104.718;326.66;109.464;39.7754;162.134;254.954;191.769;127.579;57.6936 237.101;506.507;6610.49;543.288;237.081;495.344;258.668;140.784;795.183;447.21;2610.68;364.247;153.26 2 78968;245920 SREBF1_32750;CXCL10_8408 261.031 261.031 117.44336528727376 152.4905 152.4905 49.829107763434735 1200.7255 1200.7255 1204.831466289165 177.986;344.076 117.256;187.725 348.781;2052.67 0 Exp 2,5(0.34);Exp 5,1(0.07);Linear,7(0.47);Poly 2,2(0.14) 1.985467882433111 30.153990149497986 1.5889767408370972 2.8712503910064697 0.34004370531053135 1.9169143438339233 186.5687367576832 293.6880099089835 118.17634395035392 194.2576560496461 195.990719444536 1910.8484805554644 UP 0.8666666666666667 0.13333333333333333 0.0 GO:0006066 4 alcohol metabolic process 93 100 7 7 6 5 5 5 54 95 2393 0.97366 0.079322 0.079322 5.0 78968;362282;497009;24450;25315 srebf1;pck1;naaa;hmgcs2;ephx1 SREBF1_32750;PCK1_9439;NAAA_32484;HMGCS2_8812;EPHX1_8567 167.76148 177.986 12.5094 98.03254010965951 166.46315303908275 60.21255448912882 107.8122 117.256 3.282 62.50528245036576 111.9475865491308 37.14381973727647 392.56732 348.781 61.3966 276.91289618382166 334.7047483910738 189.63908100868534 4.0 269.456 177.986;227.854;151.002;269.456;12.5094 117.256;148.568;107.821;162.134;3.282 348.781;506.507;250.969;795.183;61.3966 4 1 4 362282;497009;24450;25315 PCK1_9439;NAAA_32484;HMGCS2_8812;EPHX1_8567 165.20535 189.428 113.0056630879916 105.45124999999999 128.1945 71.91698834709828 403.5139 378.738 318.49984616308166 227.854;151.002;269.456;12.5094 148.568;107.821;162.134;3.282 506.507;250.969;795.183;61.3966 1 78968 SREBF1_32750 177.986 177.986 117.256 117.256 348.781 348.781 177.986 117.256 348.781 0 Exp 2,2(0.4);Hill,1(0.2);Linear,2(0.4) 1.9695089856010846 9.91181194782257 1.5889767408370972 2.162810802459717 0.24253142749653395 2.1014184951782227 81.83216991266805 253.69079008733195 53.02390427935778 162.60049572064224 149.84246459236002 635.29217540764 UP 0.8 0.2 0.0 GO:0072503 8 cellular divalent inorganic cation homeostasis 114 121 6 6 6 4 4 4 55 117 2371 0.85414 0.30692 0.36163 3.31 24567;24494;24408;245920 mt1;il1b;grin1;cxcl10 MT1A_9255;IL1B_8892;GRIN1_32381;CXCL10_8408 300.21125 327.0505 153.991 103.22267674748926 302.2223709943678 101.36567153150635 190.8845 199.56 109.464 61.00508640269273 188.44862444163914 58.31318037323822 2342.2595 1249.94 258.668 2957.150645805463 2311.73492649058 2813.6977606382825 392.753;153.991;310.025;344.076 211.395;109.464;254.954;187.725 6610.49;258.668;447.21;2052.67 3 1 3 24567;24494;24408 MT1A_9255;IL1B_8892;GRIN1_32381 285.5896666666667 310.025 121.24206076000738 191.9376666666667 211.395 74.67111818054771 2438.789333333333 447.21 3614.028480884086 392.753;153.991;310.025 211.395;109.464;254.954 6610.49;258.668;447.21 1 245920 CXCL10_8408 344.076 344.076 187.725 187.725 2052.67 2052.67 344.076 187.725 2052.67 0 Exp 2,2(0.5);Linear,2(0.5) 2.258325084057431 9.171507716178894 1.912996768951416 2.8712503910064697 0.46607152868151475 2.193630278110504 199.0530267874605 401.3694732125395 131.09951532536118 250.66948467463882 -555.7481328893537 5240.267132889354 UP 0.75 0.25 0.0 GO:1902932 7 positive regulation of alcohol biosynthetic process 13 14 2 2 2 2 2 2 57 12 2476 0.99642 0.040155 0.040155 14.29 78968;24494 srebf1;il1b SREBF1_32750;IL1B_8892 165.9885 165.9885 153.991 16.967027214571576 165.45927300548755 16.950511793941885 113.36 113.36 109.464 5.5097760390058435 113.18814183199662 5.504412915124088 303.72450000000003 303.72450000000003 258.668 63.71951337306309 301.73699292950613 63.65748986403344 0.0 153.991 0.5 165.9885 177.986;153.991 117.256;109.464 348.781;258.668 1 1 1 24494 IL1B_8892 153.991 153.991 109.464 109.464 258.668 258.668 153.991 109.464 258.668 1 78968 SREBF1_32750 177.986 177.986 117.256 117.256 348.781 348.781 177.986 117.256 348.781 0 Exp 2,1(0.5);Linear,1(0.5) 2.135965844396558 4.460227131843567 1.5889767408370972 2.8712503910064697 0.9067043933715901 2.2301135659217834 142.47340000000003 189.50359999999995 105.72384 120.99616 215.41376000000005 392.03524000000004 CONFLICT 0.5 0.5 0.0 GO:0006464 6 cellular protein modification process 420 450 12 11 9 9 8 8 51 442 2046 0.25991 0.84432 0.49129 1.78 365377;303872;362282;24494;84488;171142;297594;29650 trim72;pigz;pck1;il1b;fgf13;ehhadh;cdca3;adam10 TRIM72_33144;PIGZ_32744;PCK1_9439;IL1B_8892;FGF13_32529;EHHADH_8534;CDCA3_8260;ADAM10_7983 222.43635 218.80700000000002 82.0928 87.34508121342607 206.67702543307294 93.154317999842 137.24257500000002 139.32100000000003 49.3056 49.510688891122975 128.3591240508975 55.015260891482576 539.984625 471.428 193.467 365.00243351828186 436.20290680113925 235.75666860209645 82.0928;355.097;227.854;153.991;209.76;250.691;183.234;316.771 49.3056;212.48;148.568;109.464;130.074;157.555;111.531;178.963 193.467;459.59;506.507;258.668;483.266;636.947;407.422;1374.01 5 3 5 365377;303872;362282;24494;171142 TRIM72_33144;PIGZ_32744;PCK1_9439;IL1B_8892;EHHADH_8534 213.94516000000004 227.854 103.01347079594971 135.47452 148.568 60.60210534752072 411.0358 459.59 182.3871293860945 82.0928;355.097;227.854;153.991;250.691 49.3056;212.48;148.568;109.464;157.555 193.467;459.59;506.507;258.668;636.947 3 84488;297594;29650 FGF13_32529;CDCA3_8260;ADAM10_7983 236.58833333333337 209.76 70.69548920782229 140.18933333333334 130.074 34.835450798480196 754.8993333333334 483.266 537.5049685996709 209.76;183.234;316.771 130.074;111.531;178.963 483.266;407.422;1374.01 0 Exp 2,4(0.5);Linear,2(0.25);Poly 2,2(0.25) 1.884165495478916 15.352951765060425 1.6072115898132324 2.8712503910064697 0.4266911958945565 1.7557016611099243 161.90929675528275 282.96340324471726 102.9334180209921 171.55173197900794 287.0508430274382 792.9184069725617 UP 0.625 0.375 0.0 GO:0009893 5 positive regulation of metabolic process 777 837 25 25 22 17 16 16 43 821 1667 0.21058 0.86306 0.40106 1.91 360243;313506;78968;294228;291773;362282;25247;681410;24494;24451;24408;304729;84488;25311;502902;24232 top2a;stil;srebf1;rt1-s3;taf4b;pck1;nsg1;loc681410;il1b;hmox1;grin1;gli2;fgf13;dcc;clec7a;c3 TOP2A_10059;STIL_33274;SREBF1_32750;RT1-S3_9763;RGD1562997_32695;PCK1_9439;NSG1_32675;LOC681410_33126;IL1B_8892;HMOX1_8815;GRIN1_32381;GLI2_8713;FGF13_32529;DCC_32537;CLEC7A_32927;C3_8175 241.3367875 223.53050000000002 61.2776 92.21361337808263 240.48650433490772 93.90169698592653 164.3764375 156.156 39.7754 82.73765585876744 164.75672896525626 84.61329845892904 501.70643750000005 483.916 140.784 292.4077297808588 489.32918344522136 291.9065062576932 203.468;311.636;177.986;219.207;279.902;227.854;216.472;410.591;153.991;61.2776;310.025;273.717;209.76;248.198;412.985;144.319 108.442;177.242;117.256;141.536;166.045;148.568;166.237;326.66;109.464;39.7754;254.954;163.744;130.074;183.659;338.673;57.6936 572.253;1285.89;348.781;484.566;888.462;506.507;342.576;495.344;258.668;140.784;447.21;831.582;483.266;299.409;488.745;153.26 8 8 8 362282;25247;681410;24494;24451;24408;502902;24232 PCK1_9439;NSG1_32675;LOC681410_33126;IL1B_8892;HMOX1_8815;GRIN1_32381;CLEC7A_32927;C3_8175 242.189325 222.163 127.10257116828069 180.253125 157.4025 115.3122333257435 354.13675 394.89300000000003 153.55640618422362 227.854;216.472;410.591;153.991;61.2776;310.025;412.985;144.319 148.568;166.237;326.66;109.464;39.7754;254.954;338.673;57.6936 506.507;342.576;495.344;258.668;140.784;447.21;488.745;153.26 8 360243;313506;78968;294228;291773;304729;84488;25311 TOP2A_10059;STIL_33274;SREBF1_32750;RT1-S3_9763;RGD1562997_32695;GLI2_8713;FGF13_32529;DCC_32537 240.48424999999997 233.7025 45.439415045122104 148.49975 152.64 28.211725215641422 649.276125 528.4095 331.4574341710681 203.468;311.636;177.986;219.207;279.902;273.717;209.76;248.198 108.442;177.242;117.256;141.536;166.045;163.744;130.074;183.659 572.253;1285.89;348.781;484.566;888.462;831.582;483.266;299.409 0 Exp 2,6(0.38);Exp 5,1(0.07);Linear,5(0.32);Poly 2,4(0.25) 1.9555272760677738 32.06252384185791 1.5889767408370972 3.437419891357422 0.5049083335381396 1.851015031337738 196.15211694473953 286.5214580552605 123.83498612920397 204.91788887079605 358.4266499073792 644.986225092621 CONFLICT 0.5 0.5 0.0 GO:0043086 5 negative regulation of catalytic activity 212 228 5 5 5 3 3 3 56 225 2263 0.21118 0.91029 0.48429 1.32 25595;24494;24232 map2;il1b;c3 MAP2_32650;IL1B_8892;C3_8175 147.91566666666665 145.437 144.319 5.291005323503429 149.0470812976731 5.802900995704146 90.6252 104.718 57.6936 28.618155739320425 86.97559691030223 30.908547494066056 216.33633333333333 237.081 153.26 55.68184185471355 211.72537018441636 62.08003020622273 145.437;153.991;144.319 104.718;109.464;57.6936 237.081;258.668;153.26 3 0 3 25595;24494;24232 MAP2_32650;IL1B_8892;C3_8175 147.91566666666665 145.437 5.291005323503429 90.6252 104.718 28.618155739320425 216.33633333333333 237.081 55.68184185471355 145.437;153.991;144.319 104.718;109.464;57.6936 237.081;258.668;153.26 0 0 Exp 5,1(0.34);Linear,2(0.67) 2.192039724772518 6.722666501998901 1.7257766723632812 2.8712503910064697 0.5813684953413886 2.1256394386291504 141.928330504963 153.90300282837032 58.2407081571777 123.00969184282232 153.32639762109892 279.34626904556774 UP 1.0 0.0 0.0 GO:0007611 5 learning or memory 75 79 6 6 5 5 4 4 55 75 2413 0.96578 0.10822 0.10822 5.06 79212;24494;24408;84488 slc6a1;il1b;grin1;fgf13 SLC6A1_32594;IL1B_8892;GRIN1_32381;FGF13_32529 204.80525 181.8755 145.445 75.72201930031095 193.15476584148115 70.01502708883883 149.80349999999999 119.769 104.722 70.95890294858482 139.2382552111504 63.815980077007964 356.56125000000003 352.93899999999996 237.101 126.6558713927229 341.53955564801333 128.76596864993198 2.5 259.8925 145.445;153.991;310.025;209.76 104.722;109.464;254.954;130.074 237.101;258.668;447.21;483.266 3 1 3 79212;24494;24408 SLC6A1_32594;IL1B_8892;GRIN1_32381 203.15366666666668 153.991 92.6518750233007 156.38 109.464 85.40050789076143 314.32633333333337 258.668 115.58475471416347 145.445;153.991;310.025 104.722;109.464;254.954 237.101;258.668;447.21 1 84488 FGF13_32529 209.76 209.76 130.074 130.074 483.266 483.266 209.76 130.074 483.266 0 Exp 2,2(0.5);Linear,2(0.5) 2.069224504201611 8.453892350196838 1.6639630794525146 2.8712503910064697 0.5251665860326813 1.959339439868927 130.59767108569525 279.01282891430475 80.26377511038694 219.34322488961303 232.43849603513138 480.68400396486857 UP 0.75 0.25 0.0 GO:0032101 5 regulation of response to external stimulus 254 266 12 12 11 8 8 8 51 258 2230 0.84391 0.27008 0.39055 3.01 294228;24494;24408;80841;245920;502902;24232;29650 rt1-s3;il1b;grin1;fabp7;cxcl10;clec7a;c3;adam10 RT1-S3_9763;IL1B_8892;GRIN1_32381;FABP7_8592;CXCL10_8408;CLEC7A_32927;C3_8175;ADAM10_7983 266.1715 269.01149999999996 144.319 95.02039665551524 268.5596062790009 98.96692101934734 182.991075 183.344 57.6936 86.5370855882155 186.22588878961398 91.26966345900028 691.693625 465.888 153.26 666.8919175419951 681.117687209991 683.4942660730504 219.207;153.991;310.025;227.998;344.076;412.985;144.319;316.771 141.536;109.464;254.954;194.92;187.725;338.673;57.6936;178.963 484.566;258.668;447.21;274.42;2052.67;488.745;153.26;1374.01 5 3 5 24494;24408;80841;502902;24232 IL1B_8892;GRIN1_32381;FABP7_8592;CLEC7A_32927;C3_8175 249.8636 227.998 112.95719064229601 191.14092 194.92 112.17331649029545 324.4606 274.42 139.82055695354686 153.991;310.025;227.998;412.985;144.319 109.464;254.954;194.92;338.673;57.6936 258.668;447.21;274.42;488.745;153.26 3 294228;245920;29650 RT1-S3_9763;CXCL10_8408;ADAM10_7983 293.35133333333334 316.771 65.64622898791167 169.40800000000002 178.963 24.532212476659943 1303.7486666666666 1374.01 786.4095815319985 219.207;344.076;316.771 141.536;187.725;178.963 484.566;2052.67;1374.01 0 Exp 2,2(0.25);Exp 5,1(0.13);Linear,4(0.5);Poly 2,1(0.13) 2.2928372986366132 19.796563148498535 1.6434866189956665 5.283818244934082 1.2087406856845069 2.008384644985199 200.32572451037277 332.0172754896273 123.02393415732308 242.9582158426769 229.56110373180434 1153.8261462681958 UP 0.625 0.375 0.0 GO:0051272 6 positive regulation of cellular component movement 192 200 12 12 10 10 8 8 51 192 2296 0.96204 0.086868 0.13348 4.0 366669;25595;24494;24451;24408;245920;502902;29650 syne2;map2;il1b;hmox1;grin1;cxcl10;clec7a;adam10 SYNE2_9977;MAP2_32650;IL1B_8892;HMOX1_8815;GRIN1_32381;CXCL10_8408;CLEC7A_32927;ADAM10_7983 252.66495000000003 293.39099999999996 61.2776 119.46439144288972 270.4781098069917 127.0273298035339 172.39405 171.92149999999998 39.7754 93.29479383801193 188.75951504621963 103.84216623758121 732.259875 467.97749999999996 140.784 668.8214204540141 777.2830557345457 737.2605433274807 276.757;145.437;153.991;61.2776;310.025;344.076;412.985;316.771 164.88;104.718;109.464;39.7754;254.954;187.725;338.673;178.963 858.911;237.081;258.668;140.784;447.21;2052.67;488.745;1374.01 5 3 5 25595;24494;24451;24408;502902 MAP2_32650;IL1B_8892;HMOX1_8815;GRIN1_32381;CLEC7A_32927 216.74312 153.991 141.7782633419947 169.51688 109.464 123.03595946458907 314.4976 258.668 147.70022557294902 145.437;153.991;61.2776;310.025;412.985 104.718;109.464;39.7754;254.954;338.673 237.081;258.668;140.784;447.21;488.745 3 366669;245920;29650 SYNE2_9977;CXCL10_8408;ADAM10_7983 312.5346666666667 316.771 33.858851580249464 177.18933333333334 178.963 11.525316756312437 1428.5303333333334 1374.01 598.7440918959722 276.757;344.076;316.771 164.88;187.725;178.963 858.911;2052.67;1374.01 0 Exp 2,1(0.13);Linear,5(0.63);Poly 2,2(0.25) 2.020481614189958 16.468574166297913 1.5923793315887451 2.8712503910064697 0.43783945696693716 2.008384644985199 169.88035032640033 335.4495496735997 107.74405625518604 237.04404374481396 268.7902764302646 1195.7294735697353 UP 0.625 0.375 0.0 GO:0016043 4 cellular component organization 805 877 31 31 26 24 20 20 39 857 1631 0.52589 0.58416 1.0 2.28 246118;365377;360243;366669;313506;25247;338475;288280;316273;25595;24503;24408;304729;84488;25311;500545;24232;298566;29650;170924 tubb3;trim72;top2a;syne2;stil;nsg1;nrep;ncam2;mcm3;map2;ina;grin1;gli2;fgf13;dcc;cdca8;c3;c1qa;adam10;abcc4 TUBB3_32820;TRIM72_33144;TOP2A_10059;SYNE2_9977;STIL_33274;NSG1_32675;NREP_9364;NCAM2_32618;MCM3_9207;MAP2_32650;INA_32322;GRIN1_32381;GLI2_8713;FGF13_32529;DCC_32537;CDCA8_33310;C3_8175;C1QA_8167;ADAM10_7983;ABCC4_32768 252.95623999999998 258.3265 82.0928 79.34700962596877 256.9725521611788 83.23921735752249 165.18725999999998 164.312 49.3056 60.14117301823147 170.2990513514335 64.76748866539037 565.05195 479.0295 153.26 327.08884665331726 534.1309847171972 282.5231763616141 282.273;82.0928;203.468;276.757;311.636;216.472;222.026;314.433;229.093;145.437;305.642;310.025;273.717;209.76;248.198;453.898;144.319;268.455;316.771;244.652 238.208;49.3056;108.442;164.88;177.242;166.237;142.777;261.826;133.518;104.718;249.176;254.954;163.744;130.074;183.659;224.22;57.6936;161.753;178.963;152.355 354.06;193.467;572.253;858.911;1285.89;342.576;497.741;415.493;614.889;237.081;459.059;447.21;831.582;483.266;299.409;474.793;153.26;786.937;1374.01;619.152 10 10 10 246118;365377;25247;288280;25595;24503;24408;24232;298566;170924 TUBB3_32820;TRIM72_33144;NSG1_32675;NCAM2_32618;MAP2_32650;INA_32322;GRIN1_32381;C3_8175;C1QA_8167;ABCC4_32768 231.38008 256.5535 81.79460322714587 169.62261999999998 163.995 80.55644458299348 400.8295 384.7765 194.13192840222518 282.273;82.0928;216.472;314.433;145.437;305.642;310.025;144.319;268.455;244.652 238.208;49.3056;166.237;261.826;104.718;249.176;254.954;57.6936;161.753;152.355 354.06;193.467;342.576;415.493;237.081;459.059;447.21;153.26;786.937;619.152 10 360243;366669;313506;338475;316273;304729;84488;25311;500545;29650 TOP2A_10059;SYNE2_9977;STIL_33274;NREP_9364;MCM3_9207;GLI2_8713;FGF13_32529;DCC_32537;CDCA8_33310;ADAM10_7983 274.5324 260.9575 74.60948936845921 160.7519 164.312 33.20765960320333 729.2744 593.571 358.1107907692502 203.468;276.757;311.636;222.026;229.093;273.717;209.76;248.198;453.898;316.771 108.442;164.88;177.242;142.777;133.518;163.744;130.074;183.659;224.22;178.963 572.253;858.911;1285.89;497.741;614.889;831.582;483.266;299.409;474.793;1374.01 0 Exp 2,8(0.4);Exp 5,1(0.05);Linear,8(0.4);Poly 2,2(0.1);Power,1(0.05) 1.8980019771630527 38.692588567733765 1.5347857475280762 3.437419891357422 0.4341488094545037 1.8002861142158508 218.18087976234074 287.7316002376593 138.82922878139303 191.54529121860693 421.6989424234309 708.4049575765691 CONFLICT 0.5 0.5 0.0 GO:0009967 6 positive regulation of signal transduction 363 381 10 9 7 5 4 4 55 377 2111 0.045898 0.9839 0.094002 1.05 24494;24408;25311;24232 il1b;grin1;dcc;c3 IL1B_8892;GRIN1_32381;DCC_32537;C3_8175 214.13325 201.0945 144.319 79.26065574787617 214.91578271028035 76.43008578002099 151.44265000000001 146.5615 57.6936 86.22370945756931 152.55037023567655 82.3711051049379 289.63675 279.0385 153.26 121.76823258790989 289.06885239739944 114.95656909488821 153.991;310.025;248.198;144.319 109.464;254.954;183.659;57.6936 258.668;447.21;299.409;153.26 3 1 3 24494;24408;24232 IL1B_8892;GRIN1_32381;C3_8175 202.77833333333334 153.991 93.00415329077153 140.70386666666667 109.464 102.27347312012698 286.3793333333333 258.668 148.92141928323588 153.991;310.025;144.319 109.464;254.954;57.6936 258.668;447.21;153.26 1 25311 DCC_32537 248.198 248.198 183.659 183.659 299.409 299.409 248.198 183.659 299.409 0 Exp 2,1(0.25);Exp 5,1(0.25);Linear,1(0.25);Poly 2,1(0.25) 2.0702480266014955 8.447828650474548 1.7257766723632812 2.8712503910064697 0.5149149363618195 1.9254007935523987 136.45780736708136 291.80869263291856 66.94341473158204 235.94188526841793 170.30388206384828 408.96961793615174 UP 0.75 0.25 0.0 GO:0044249 4 cellular biosynthetic process 372 415 12 12 10 10 9 9 50 406 2082 0.49937 0.64183 1.0 2.17 78968;29483;291773;303872;362282;24494;24450;50549;64564 srebf1;slc1a3;taf4b;pigz;pck1;il1b;hmgcs2;cyp4a1;bbox1 SREBF1_32750;SLC1A3_32817;RGD1562997_32695;PIGZ_32744;PCK1_9439;IL1B_8892;HMGCS2_8812;CYP4A1_33111;BBOX1_8133 288.6193333333333 279.902 153.991 96.26676421018833 280.99144074049013 98.15254592343499 173.51944444444447 166.045 109.464 47.144486406448145 169.78255472451605 47.83254242950314 967.5352222222222 506.507 258.668 1151.8751013004598 994.4064119060511 1264.0256637054363 177.986;303.435;279.902;355.097;227.854;153.991;269.456;375.605;454.248 117.256;189.179;166.045;212.48;148.568;109.464;162.134;197.092;259.457 348.781;992.735;888.462;459.59;506.507;258.668;795.183;3966.72;491.171 7 2 7 29483;303872;362282;24494;24450;50549;64564 SLC1A3_32817;PIGZ_32744;PCK1_9439;IL1B_8892;HMGCS2_8812;CYP4A1_33111;BBOX1_8133 305.66942857142857 303.435 99.82288694959875 182.62485714285714 189.179 48.26837906410563 1067.2248571428572 506.507 1301.0159150194163 303.435;355.097;227.854;153.991;269.456;375.605;454.248 189.179;212.48;148.568;109.464;162.134;197.092;259.457 992.735;459.59;506.507;258.668;795.183;3966.72;491.171 2 78968;291773 SREBF1_32750;RGD1562997_32695 228.944 228.944 72.06549471140809 141.6505 141.6505 34.499032747310494 618.6215 618.6215 381.61209477753727 177.986;279.902 117.256;166.045 348.781;888.462 0 Exp 2,3(0.34);Linear,4(0.45);Poly 2,1(0.12);Power,1(0.12) 1.9559449627355552 18.04963457584381 1.5810112953186035 2.8712503910064697 0.5003388908659999 1.8452895879745483 225.72504738267693 351.51361928398967 142.71837999223163 204.32050889665726 214.9768227059218 1720.0936217385229 UP 0.7777777777777778 0.2222222222222222 0.0 GO:0006721 6 terpenoid metabolic process 29 34 3 3 2 2 2 2 57 32 2456 0.9575 0.18526 0.18526 5.88 24450;25086 hmgcs2;cyp2e1 HMGCS2_8812;CYP2E1_8421 313.416 313.416 269.456 62.168828201921244 334.025972899729 54.912851265845305 176.9515 176.9515 162.134 20.95510946046303 183.89845799457999 18.509353358317505 1702.9315 1702.9315 795.183 1283.7502399238333 2128.515485094851 1133.918525188679 0.5 313.416 269.456;357.376 162.134;191.769 795.183;2610.68 2 0 2 24450;25086 HMGCS2_8812;CYP2E1_8421 313.416 313.416 62.168828201921244 176.9515 176.9515 20.95510946046303 1702.9315 1702.9315 1283.7502399238333 269.456;357.376 162.134;191.769 795.183;2610.68 0 0 Linear,2(1) 1.8578349891990769 3.716992974281311 1.8089147806167603 1.9080781936645508 0.07011912181169525 1.8584964871406555 227.25440000000003 399.57759999999996 147.9092 205.99380000000002 -76.2555599999996 3482.1185599999994 UP 1.0 0.0 0.0 GO:0019730 4 antimicrobial humoral response 29 34 2 2 2 2 2 2 57 32 2456 0.9575 0.18526 0.18526 5.88 294228;245920 rt1-s3;cxcl10 RT1-S3_9763;CXCL10_8408 281.6415 281.6415 219.207 88.29571665998316 272.5232037714066 87.34899500438 164.63049999999998 164.63049999999998 141.536 32.66055511622566 161.2576453723302 32.31036310259011 1268.618 1268.618 484.566 1108.81697200575 1154.1105018279777 1096.9280482934005 0.5 281.6415 219.207;344.076 141.536;187.725 484.566;2052.67 0 2 0 2 294228;245920 RT1-S3_9763;CXCL10_8408 281.6415 281.6415 88.29571665998316 164.63049999999998 164.63049999999998 32.66055511622566 1268.618 1268.618 1108.81697200575 219.207;344.076 141.536;187.725 484.566;2052.67 0 Linear,2(1) 2.0999652032147766 4.255461931228638 1.7851157188415527 2.470346212387085 0.4845311286618506 2.127730965614319 159.26988 404.01312 119.36528 209.89571999999998 -268.12391999999977 2805.35992 DOWN 0.0 1.0 0.0 GO:0030182 5 neuron differentiation 63 68 4 4 4 3 3 3 56 65 2423 0.92945 0.20735 0.20735 4.41 246118;360243;304729 tubb3;top2a;gli2 TUBB3_32820;TOP2A_10059;GLI2_8713 253.15266666666665 273.717 203.468 43.24032678337818 266.6458791163476 34.98613924611267 170.13133333333334 163.744 108.442 65.11837075152705 195.27147134020615 61.90399062290406 585.965 572.253 354.06 239.0561217141281 526.6467585861561 254.4338167212112 282.273;203.468;273.717 238.208;108.442;163.744 354.06;572.253;831.582 1 2 1 246118 TUBB3_32820 282.273 282.273 238.208 238.208 354.06 354.06 282.273 238.208 354.06 2 360243;304729 TOP2A_10059;GLI2_8713 238.59249999999997 238.59249999999997 49.67354427157392 136.093 136.093 39.10441921317853 701.9175 701.9175 183.37329445832617 203.468;273.717 108.442;163.744 572.253;831.582 0 Exp 2,2(0.67);Linear,1(0.34) 2.2664558763106384 6.824345827102661 2.0807507038116455 2.545419454574585 0.24162088663013126 2.1981756687164307 204.2216306225343 302.083702710799 96.44295992346868 243.81970674319797 315.44753220276374 856.4824677972363 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0045471 5 response to ethanol 109 117 7 7 6 6 5 5 54 112 2376 0.94891 0.13167 0.19203 4.27 78968;24494;24450;24408;25086 srebf1;il1b;hmgcs2;grin1;cyp2e1 SREBF1_32750;IL1B_8892;HMGCS2_8812;GRIN1_32381;CYP2E1_8421 253.76679999999996 269.456 153.991 86.37699679717986 244.40213035921204 91.94585584838799 167.1154 162.134 109.464 59.49344014090965 164.86413367744655 64.63889431851403 892.1043999999999 447.21 258.668 981.9965462868491 832.0789519119352 1004.6958885598582 177.986;153.991;269.456;310.025;357.376 117.256;109.464;162.134;254.954;191.769 348.781;258.668;795.183;447.21;2610.68 4 1 4 24494;24450;24408;25086 IL1B_8892;HMGCS2_8812;GRIN1_32381;CYP2E1_8421 272.712 289.7405 86.92051971389354 179.58024999999998 176.9515 60.69164678589094 1027.93525 621.1965 1078.3117161320206 153.991;269.456;310.025;357.376 109.464;162.134;254.954;191.769 258.668;795.183;447.21;2610.68 1 78968 SREBF1_32750 177.986 177.986 117.256 117.256 348.781 348.781 177.986 117.256 348.781 0 Exp 2,2(0.4);Linear,3(0.6) 1.976792651921726 10.094134449958801 1.5889767408370972 2.8712503910064697 0.49449760117599967 1.9080781936645508 178.05402407993597 329.479575920064 114.96710046280765 219.26369953719234 31.346475782374 1752.8623242176259 UP 0.8 0.2 0.0 GO:0003006 3 developmental process involved in reproduction 220 234 9 9 8 5 5 5 54 229 2259 0.53844 0.64349 1.0 2.14 311715;24494;304729;50549;29650 tcfl5;il1b;gli2;cyp4a1;adam10 TCFL5_9994;IL1B_8892;GLI2_8713;CYP4A1_33111;ADAM10_7983 278.201 273.717 153.991 81.35787127254491 265.2305520617692 88.76171098617098 175.5872 178.963 109.464 44.17152242904923 168.10093744754658 47.11911196537394 1353.9694 831.582 258.668 1527.242118857976 1314.4476172998377 1615.6418342973468 270.921;153.991;273.717;375.605;316.771 228.673;109.464;163.744;197.092;178.963 338.867;258.668;831.582;3966.72;1374.01 3 2 3 311715;24494;50549 TCFL5_9994;IL1B_8892;CYP4A1_33111 266.839 270.921 110.86337669401922 178.40966666666668 197.092 61.761384410757245 1521.4183333333333 338.867 2118.0729804830457 270.921;153.991;375.605 228.673;109.464;197.092 338.867;258.668;3966.72 2 304729;29650 GLI2_8713;ADAM10_7983 295.244 295.244 30.443775357204643 171.3535 171.3535 10.761458102878318 1102.796 1102.796 383.55451710545674 273.717;316.771 163.744;178.963 831.582;1374.01 0 Exp 2,1(0.2);Linear,4(0.8) 1.9776529073808684 10.13858151435852 1.5810112953186035 2.8712503910064697 0.529455965482612 1.84465754032135 206.88768157732557 349.5143184226745 136.86915348616378 214.3052465138362 15.282659220039022 2692.656140779961 UP 0.6 0.4 0.0 GO:1905340 7 regulation of protein localization to kinetochore 2 2 1 1 1 1 1 1 58 1 2487 0.99947 0.045801 0.045801 50.0 363198 cenpq CENPQ_8290 39.9715 39.9715 39.9715 39.9715 12.1775 12.1775 12.1775 12.1775 177.403 177.403 177.403 177.40299999999996 0.0 39.9715 0.0 39.9715 39.9715 12.1775 177.403 0 1 0 1 363198 CENPQ_8290 39.9715 39.9715 12.1775 12.1775 177.403 177.403 39.9715 12.1775 177.403 0 Exp 4,1(1) 1.8991773128509521 1.8991773128509521 1.8991773128509521 1.8991773128509521 0.0 1.8991773128509521 39.9715 39.9715 12.1775 12.1775 177.403 177.403 DOWN 0.0 1.0 0.0 GO:1905342 7 positive regulation of protein localization to kinetochore 2 2 1 1 1 1 1 1 58 1 2487 0.99947 0.045801 0.045801 50.0 363198 cenpq CENPQ_8290 39.9715 39.9715 39.9715 39.9715 12.1775 12.1775 12.1775 12.1775 177.403 177.403 177.403 177.40299999999996 0.0 39.9715 0.0 39.9715 39.9715 12.1775 177.403 0 1 0 1 363198 CENPQ_8290 39.9715 39.9715 12.1775 12.1775 177.403 177.403 39.9715 12.1775 177.403 0 Exp 4,1(1) 1.8991773128509521 1.8991773128509521 1.8991773128509521 1.8991773128509521 0.0 1.8991773128509521 39.9715 39.9715 12.1775 12.1775 177.403 177.403 DOWN 0.0 1.0 0.0 GO:0043569 7 negative regulation of insulin-like growth factor receptor signaling pathway 1 1 1 1 1 1 1 1 58 0 2488 1.0 0.023165 0.023165 100.0 365377 trim72 TRIM72_33144 82.0928 82.0928 82.0928 82.0928 49.3056 49.3056 49.3056 49.3056 193.467 193.467 193.467 193.467 0.0 82.0928 0.0 82.0928 82.0928 49.3056 193.467 1 0 1 365377 TRIM72_33144 82.0928 82.0928 49.3056 49.3056 193.467 193.467 82.0928 49.3056 193.467 0 0 Poly 2,1(1) 1.6661137342453003 1.6661137342453003 1.6661137342453003 1.6661137342453003 0.0 1.6661137342453003 82.0928 82.0928 49.3056 49.3056 193.467 193.467 UP 1.0 0.0 0.0 GO:0031343 6 positive regulation of cell killing 21 30 2 2 2 2 2 2 57 28 2460 0.96923 0.15209 0.15209 6.67 294228;502902 rt1-s3;clec7a RT1-S3_9763;CLEC7A_32927 316.096 316.096 219.207 137.02173784476682 301.9315230611329 135.5495917666172 240.1045 240.1045 141.536 139.3969095227724 225.69449220604272 137.89924486833195 486.65549999999996 486.65549999999996 484.566 2.9549992385982184 486.3500300853165 2.923251060478388 0.5 316.096 219.207;412.985 141.536;338.673 484.566;488.745 1 1 1 502902 CLEC7A_32927 412.985 412.985 338.673 338.673 488.745 488.745 412.985 338.673 488.745 1 294228 RT1-S3_9763 219.207 219.207 141.536 141.536 484.566 484.566 219.207 141.536 484.566 0 Linear,1(0.5);Poly 2,1(0.5) 1.936100222518298 3.8849706649780273 1.7851157188415527 2.0998549461364746 0.22255424192565337 1.9424853324890137 126.19355999999999 505.99844 46.910240000000044 433.29875999999996 482.5600799999999 490.75092 CONFLICT 0.5 0.5 0.0 GO:0050905 5 neuromuscular process 23 24 3 3 3 3 3 3 56 21 2467 0.99805 0.016914 0.016914 12.5 29483;24408;80841 slc1a3;grin1;fabp7 SLC1A3_32817;GRIN1_32381;FABP7_8592 280.486 303.435 227.998 45.57520853490405 283.2782965131295 44.43709170116293 213.01766666666666 194.92 189.179 36.43119282062197 215.5003519586741 37.452395942224825 571.455 447.21 274.42 374.9289597043685 573.3073852776582 367.6438314779849 0.5 265.7165 1.5 306.73 303.435;310.025;227.998 189.179;254.954;194.92 992.735;447.21;274.42 3 0 3 29483;24408;80841 SLC1A3_32817;GRIN1_32381;FABP7_8592 280.486 303.435 45.57520853490405 213.01766666666666 194.92 36.43119282062197 571.455 447.21 374.9289597043685 303.435;310.025;227.998 189.179;254.954;194.92 992.735;447.21;274.42 0 0 Exp 2,3(1) 2.570189037264624 8.877005100250244 1.6762725114822388 5.283818244934082 2.01694226448799 1.9169143438339233 228.9127965246395 332.0592034753605 171.79189106217166 254.2434422711617 147.18294180788502 995.7270581921148 UP 1.0 0.0 0.0 GO:0060033 3 anatomical structure regression 10 11 2 2 2 2 2 2 57 9 2479 0.99829 0.025371 0.025371 18.18 84487;304729 slc17a6;gli2 SLC17A6_32912;GLI2_8713 321.674 321.674 273.717 67.82143981072646 336.1748798586572 64.6467065259289 163.59699999999998 163.59699999999998 163.45 0.20788939370116855 163.5525512367491 0.1981580553385498 641.8435 641.8435 452.105 268.33076000432783 584.4717879858658 255.77015088871175 0.0 273.717 0.5 321.674 369.631;273.717 163.45;163.744 452.105;831.582 1 1 1 84487 SLC17A6_32912 369.631 369.631 163.45 163.45 452.105 452.105 369.631 163.45 452.105 1 304729 GLI2_8713 273.717 273.717 163.744 163.744 831.582 831.582 273.717 163.744 831.582 0 Hill,1(0.5);Linear,1(0.5) 2.0265343068047614 4.066470980644226 1.8682953119277954 2.1981756687164307 0.23326063726548174 2.033235490322113 227.67827999999997 415.66972 163.30887999999996 163.88512 269.95604 1013.7309599999999 CONFLICT 0.5 0.5 0.0 GO:0001906 3 cell killing 31 37 3 3 3 3 3 3 56 34 2454 0.9903 0.05257 0.05257 8.11 25211;245920;24232 lyz2;cxcl10;c3 LYZ2_32611;CXCL10_8408;C3_8175 234.37 214.715 144.319 101.31857692940619 248.8467765318134 103.12421544853864 128.31820000000002 139.536 57.6936 65.73751230553216 137.0649459265225 64.58063433734411 890.087 464.331 153.26 1018.7692161019589 1034.4742888916423 1054.8732867115862 0.5 179.517 214.715;344.076;144.319 139.536;187.725;57.6936 464.331;2052.67;153.26 2 1 2 25211;24232 LYZ2_32611;C3_8175 179.517 179.517 49.77748896840822 98.6148 98.6148 57.87131602858189 308.7955 308.7955 219.96041353048057 214.715;144.319 139.536;57.6936 464.331;153.26 1 245920 CXCL10_8408 344.076 344.076 187.725 187.725 2052.67 2052.67 344.076 187.725 2052.67 0 Exp 5,1(0.34);Linear,2(0.67) 1.8814694274868962 5.758367657661438 1.5622447729110718 2.470346212387085 0.4840410978501917 1.7257766723632812 119.71723697835914 349.02276302164086 53.9292019661075 202.7071980338925 -262.7588950707975 2042.9328950707975 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0033762 6 response to glucagon 17 18 3 3 3 3 3 3 56 15 2473 0.99938 0.0075242 0.0075242 16.67 78968;362282;24450 srebf1;pck1;hmgcs2 SREBF1_32750;PCK1_9439;HMGCS2_8812 225.09866666666667 227.854 177.986 45.79720647958041 204.835147299509 44.6672633138662 142.65266666666665 148.568 117.256 23.016344134839077 131.7650136388434 23.16417105944548 550.157 506.507 348.781 226.37950056487023 463.09761893071465 208.84097931353347 0.0 177.986 0.5 202.92000000000002 177.986;227.854;269.456 117.256;148.568;162.134 348.781;506.507;795.183 2 1 2 362282;24450 PCK1_9439;HMGCS2_8812 248.65500000000003 248.65500000000003 29.417056310922636 155.351 155.351 9.592610593576623 650.845 650.845 204.1247571658077 227.854;269.456 148.568;162.134 506.507;795.183 1 78968 SREBF1_32750 177.986 177.986 117.256 117.256 348.781 348.781 177.986 117.256 348.781 0 Exp 2,2(0.67);Linear,1(0.34) 1.871733784987281 5.659865736961365 1.5889767408370972 2.162810802459717 0.28751810651925186 1.9080781936645508 173.274248867994 276.92308446533934 116.60722140192648 168.69811193140686 293.9844794433241 806.329520556676 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0001558 5 regulation of cell growth 111 120 6 6 6 3 3 3 56 117 2371 0.69841 0.53233 0.75598 2.5 25595;84488;29650 map2;fgf13;adam10 MAP2_32650;FGF13_32529;ADAM10_7983 223.98933333333335 209.76 145.437 86.54877430867133 216.1442673048601 54.75928386291477 137.91833333333332 130.074 104.718 37.73897428830487 133.48686855670107 24.09177409767603 698.119 483.266 237.081 598.1414936843959 572.0112946735395 398.0477803250062 145.437;209.76;316.771 104.718;130.074;178.963 237.081;483.266;1374.01 1 2 1 25595 MAP2_32650 145.437 145.437 104.718 104.718 237.081 237.081 145.437 104.718 237.081 2 84488;29650 FGF13_32529;ADAM10_7983 263.2655 263.2655 75.66820376155377 154.51850000000002 154.51850000000002 34.56974342542905 928.638 928.638 629.8511227012301 209.76;316.771 130.074;178.963 483.266;1374.01 0 Exp 2,1(0.34);Linear,2(0.67) 1.7980419465699296 5.4330891370773315 1.6434866189956665 2.1256394386291504 0.2726523083635865 1.6639630794525146 126.05017536885194 321.92849129781473 95.21266368331877 180.62400298334794 21.25818131134531 1374.9798186886546 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0022402 3 cell cycle process 177 191 8 8 7 6 5 5 54 186 2302 0.7211 0.45744 0.8002 2.62 360243;313506;316273;363198;500545 top2a;stil;mcm3;cenpq;cdca8 TOP2A_10059;STIL_33274;MCM3_9207;CENPQ_8290;CDCA8_33310 247.61329999999998 229.093 39.9715 151.70630318216845 232.7618553669464 158.776846017898 131.1199 133.518 12.1775 79.78441150719854 123.43807777497317 84.3807268435117 625.0456 572.253 177.403 406.9905641692446 572.7825787530763 390.51767618228394 203.468;311.636;229.093;39.9715;453.898 108.442;177.242;133.518;12.1775;224.22 572.253;1285.89;614.889;177.403;474.793 0 5 0 5 360243;313506;316273;363198;500545 TOP2A_10059;STIL_33274;MCM3_9207;CENPQ_8290;CDCA8_33310 247.61329999999998 229.093 151.70630318216845 131.1199 133.518 79.78441150719854 625.0456 572.253 406.9905641692446 203.468;311.636;229.093;39.9715;453.898 108.442;177.242;133.518;12.1775;224.22 572.253;1285.89;614.889;177.403;474.793 0 Exp 2,2(0.4);Exp 4,1(0.2);Linear,1(0.2);Power,1(0.2) 1.8845425185473375 9.45356011390686 1.6343638896942139 2.0807507038116455 0.16789716007194294 1.8991773128509521 114.6368622400357 380.58973775996435 61.185779871434335 201.05402012856567 268.30264146809895 981.7885585319011 DOWN 0.0 1.0 0.0 GO:0009056 3 catabolic process 364 413 15 15 15 10 10 10 49 403 2085 0.6433 0.49399 0.8583 2.42 365377;362282;497009;24451;316098;25315;171142;29740;25086;25279 trim72;pck1;naaa;hmox1;exosc7;ephx1;ehhadh;eci1;cyp2e1;cyp24a1 TRIM72_33144;PCK1_9439;NAAA_32484;HMOX1_8815;EXOSC7_8580;EPHX1_8567;EHHADH_8534;ECI1_8520;CYP2E1_8421;CYP24A1_32574 163.96568 170.0565 12.5094 102.04065217698287 168.29532427760577 89.72406204562205 101.1319 117.69999999999999 3.282 60.95151967517573 106.35007305641555 52.6210187529348 552.65256 368.887 61.3966 743.1464662313304 515.5773842965256 678.2991581561839 82.0928;227.854;151.002;61.2776;111.985;12.5094;250.691;195.758;357.376;189.111 49.3056;148.568;107.821;39.7754;54.886;3.282;157.555;130.778;191.769;127.579 193.467;506.507;250.969;140.784;373.527;61.3966;636.947;388.001;2610.68;364.247 10 0 10 365377;362282;497009;24451;316098;25315;171142;29740;25086;25279 TRIM72_33144;PCK1_9439;NAAA_32484;HMOX1_8815;EXOSC7_8580;EPHX1_8567;EHHADH_8534;ECI1_8520;CYP2E1_8421;CYP24A1_32574 163.96568 170.0565 102.04065217698287 101.1319 117.69999999999999 60.95151967517573 552.65256 368.887 743.1464662313304 82.0928;227.854;151.002;61.2776;111.985;12.5094;250.691;195.758;357.376;189.111 49.3056;148.568;107.821;39.7754;54.886;3.282;157.555;130.778;191.769;127.579 193.467;506.507;250.969;140.784;373.527;61.3966;636.947;388.001;2610.68;364.247 0 0 Exp 2,2(0.2);Hill,1(0.1);Linear,4(0.4);Poly 2,3(0.3) 1.8530338478635988 18.69570744037628 1.5261523723602295 2.162810802459717 0.26075559230275297 1.86702299118042 100.72022853757616 227.21113146242382 63.35375671166417 138.91004328833583 92.04560819430367 1013.2595118056963 UP 1.0 0.0 0.0 GO:0016567 9 protein ubiquitination 75 76 3 3 2 3 2 2 57 74 2414 0.74304 0.53143 0.69537 2.63 365377;297594 trim72;cdca3 TRIM72_33144;CDCA3_8260 132.6634 132.6634 82.0928 71.51762837734488 119.98576301481361 69.23385161655872 80.4183 80.4183 49.3056 44.00000230204542 72.61859985349179 42.594947562229976 300.4445 300.4445 193.467 151.28903136876775 273.6261132182973 146.4579095622833 82.0928;183.234 49.3056;111.531 193.467;407.422 1 1 1 365377 TRIM72_33144 82.0928 82.0928 49.3056 49.3056 193.467 193.467 82.0928 49.3056 193.467 1 297594 CDCA3_8260 183.234 183.234 111.531 111.531 407.422 407.422 183.234 111.531 407.422 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.7758556614619303 3.5589396953582764 1.6661137342453003 1.892825961112976 0.16030975299603653 1.7794698476791382 33.545024 231.78177599999998 19.437407999999998 141.399192 90.76860000000002 510.1204 CONFLICT 0.5 0.5 0.0 GO:0043090 7 amino acid import 8 8 2 2 2 2 2 2 57 6 2482 0.99939 0.013505 0.013505 25.0 79212;29483 slc6a1;slc1a3 SLC6A1_32594;SLC1A3_32817 224.44 224.44 145.445 111.71580035966258 193.41439083039435 102.73871325508102 146.9505 146.9505 104.722 59.720117418672245 130.36508400128247 54.921219731529746 614.918 614.918 237.101 534.3139254951157 466.52882879127924 491.37834579270793 0.0 145.445 0.0 145.445 145.445;303.435 104.722;189.179 237.101;992.735 2 0 2 79212;29483 SLC6A1_32594;SLC1A3_32817 224.44 224.44 111.71580035966258 146.9505 146.9505 59.720117418672245 614.918 614.918 534.3139254951157 145.445;303.435 104.722;189.179 237.101;992.735 0 0 Exp 2,1(0.5);Linear,1(0.5) 1.8318031733774673 3.6780370473861694 1.6762725114822388 2.0017645359039307 0.23015761769071566 1.8390185236930847 69.6098 379.2702 64.18263999999999 229.71836000000002 -125.60331999999994 1355.43932 UP 1.0 0.0 0.0 GO:0032774 6 RNA biosynthetic process 71 78 3 3 2 3 2 2 57 76 2412 0.73036 0.54566 0.70186 2.56 78968;291773 srebf1;taf4b SREBF1_32750;RGD1562997_32695 228.944 228.944 177.986 72.06549471140809 209.0318074619991 66.33584780990687 141.6505 141.6505 117.256 34.499032747310494 132.11817964071855 31.75614897364078 618.6215 618.6215 348.781 381.61209477753727 513.1794498694918 351.2716029072813 177.986;279.902 117.256;166.045 348.781;888.462 0 2 0 2 78968;291773 SREBF1_32750;RGD1562997_32695 228.944 228.944 72.06549471140809 141.6505 141.6505 34.499032747310494 618.6215 618.6215 381.61209477753727 177.986;279.902 117.256;166.045 348.781;888.462 0 Exp 2,1(0.5);Linear,1(0.5) 1.6134139508683603 3.2272037267684937 1.5889767408370972 1.6382269859313965 0.034825182281278545 1.6136018633842468 129.06632000000002 328.82167999999996 93.83728000000002 189.46371999999997 89.73411999999996 1147.5088799999999 DOWN 0.0 1.0 0.0 GO:0006810 4 transport 570 605 16 16 14 13 11 11 48 594 1894 0.22136 0.86307 0.4391 1.82 365377;366669;79212;29483;84487;25247;311024;24408;84488;29650;170924 trim72;syne2;slc6a1;slc1a3;slc17a6;nsg1;kif5c;grin1;fgf13;adam10;abcc4 TRIM72_33144;SYNE2_9977;SLC6A1_32594;SLC1A3_32817;SLC17A6_32912;NSG1_32675;KIF5C_8965;GRIN1_32381;FGF13_32529;ADAM10_7983;ABCC4_32768 248.3507090909091 256.817 82.0928 82.3755367504874 236.16481078427879 96.57320201431583 160.22078181818182 164.88 49.3056 53.75688873217677 148.3544375920327 58.551475237115625 579.3429090909091 452.105 193.467 359.1645292849657 467.17261444069 270.5498094040276 82.0928;276.757;145.445;303.435;369.631;216.472;256.817;310.025;209.76;316.771;244.652 49.3056;164.88;104.722;189.179;163.45;166.237;208.309;254.954;130.074;178.963;152.355 193.467;858.911;237.101;992.735;452.105;342.576;372.239;447.21;483.266;1374.01;619.152 8 3 8 365377;79212;29483;84487;25247;311024;24408;170924 TRIM72_33144;SLC6A1_32594;SLC1A3_32817;SLC17A6_32912;NSG1_32675;KIF5C_8965;GRIN1_32381;ABCC4_32768 241.07122499999997 250.7345 92.93305350845304 161.06395 164.8435 62.8041580635959 457.07312500000006 409.7245 253.9706155283308 82.0928;145.445;303.435;369.631;216.472;256.817;310.025;244.652 49.3056;104.722;189.179;163.45;166.237;208.309;254.954;152.355 193.467;237.101;992.735;452.105;342.576;372.239;447.21;619.152 3 366669;84488;29650 SYNE2_9977;FGF13_32529;ADAM10_7983 267.7626666666667 276.757 54.069511319534946 157.97233333333335 164.88 25.165859300515322 905.3956666666667 858.911 447.18769723722653 276.757;209.76;316.771 164.88;130.074;178.963 858.911;483.266;1374.01 0 Exp 2,5(0.46);Hill,1(0.1);Linear,4(0.37);Poly 2,1(0.1) 1.9040525284376046 21.514907717704773 1.5415009260177612 3.437419891357422 0.5405128944026325 1.748702883720398 199.66987775283835 297.03154042897984 128.45249068634837 191.98907295001533 367.09023599818397 791.5955821836342 UP 0.7272727272727273 0.2727272727272727 0.0 GO:0043627 3 response to estrogen 45 49 3 3 2 3 2 2 57 47 2441 0.89717 0.31475 0.31475 4.08 24451;24232 hmox1;c3 HMOX1_8815;C3_8175 102.7983 102.7983 61.2776 58.71913705922455 101.47127927512356 58.68913944650658 48.7345 48.7345 39.7754 12.670080726656805 48.44816303130148 12.663608012755047 147.022 147.022 140.784 8.821864202083367 146.82263064250412 8.817357411298824 61.2776;144.319 39.7754;57.6936 140.784;153.26 2 0 2 24451;24232 HMOX1_8815;C3_8175 102.7983 102.7983 58.71913705922455 48.7345 48.7345 12.670080726656805 147.022 147.022 8.821864202083367 61.2776;144.319 39.7754;57.6936 140.784;153.26 0 0 Exp 5,1(0.5);Poly 2,1(0.5) 1.6577367414668984 3.3181560039520264 1.5923793315887451 1.7257766723632812 0.09432616425392723 1.6590780019760132 21.41772800000001 184.17887199999996 31.174663999999993 66.294336 134.79551999999998 159.24848 UP 1.0 0.0 0.0 GO:0007196 7 adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway 1 1 1 1 1 1 1 1 58 0 2488 1.0 0.023165 0.023165 100.0 24416 grm3 GRM3_33234 286.986 286.986 286.986 286.986 241.819 241.819 241.819 241.819 363.86 363.86 363.86 363.86 0.0 286.986 0.0 286.986 286.986 241.819 363.86 1 0 1 24416 GRM3_33234 286.986 286.986 241.819 241.819 363.86 363.86 286.986 241.819 363.86 0 0 Exp 2,1(1) 3.6677837371826176 3.667783737182617 3.667783737182617 3.667783737182617 0.0 3.667783737182617 286.986 286.986 241.819 241.819 363.86 363.86 UP 1.0 0.0 0.0 GO:0019538 4 protein metabolic process 588 639 14 13 11 10 9 9 50 630 1858 0.048454 0.97725 0.093713 1.41 365377;303872;362282;25247;24494;84488;171142;297594;29650 trim72;pigz;pck1;nsg1;il1b;fgf13;ehhadh;cdca3;adam10 TRIM72_33144;PIGZ_32744;PCK1_9439;NSG1_32675;IL1B_8892;FGF13_32529;EHHADH_8534;CDCA3_8260;ADAM10_7983 221.77364444444444 216.472 82.0928 81.72802712985171 207.20647697478992 89.92177085931317 140.4641777777778 148.568 49.3056 47.31071015409129 130.40655150271874 53.859738092079965 518.0503333333334 459.59 193.467 347.71173085366263 431.14205546218494 228.6035610134568 82.0928;355.097;227.854;216.472;153.991;209.76;250.691;183.234;316.771 49.3056;212.48;148.568;166.237;109.464;130.074;157.555;111.531;178.963 193.467;459.59;506.507;342.576;258.668;483.266;636.947;407.422;1374.01 6 3 6 365377;303872;362282;25247;24494;171142 TRIM72_33144;PIGZ_32744;PCK1_9439;NSG1_32675;IL1B_8892;EHHADH_8534 214.3663 222.163 92.14382391533361 140.6016 153.06150000000002 55.640038048153755 399.62583333333333 401.08299999999997 165.50883966896353 82.0928;355.097;227.854;216.472;153.991;250.691 49.3056;212.48;148.568;166.237;109.464;157.555 193.467;459.59;506.507;342.576;258.668;636.947 3 84488;297594;29650 FGF13_32529;CDCA3_8260;ADAM10_7983 236.58833333333337 209.76 70.69548920782229 140.18933333333334 130.074 34.835450798480196 754.8993333333334 483.266 537.5049685996709 209.76;183.234;316.771 130.074;111.531;178.963 483.266;407.422;1374.01 0 Exp 2,5(0.56);Linear,2(0.23);Poly 2,2(0.23) 2.0143348282476348 18.790371656417847 1.6072115898132324 3.437419891357422 0.6445500176284621 1.8452895879745483 168.37800005294133 275.16928883594755 109.5545138104381 171.3738417451175 290.878669175607 745.2219974910597 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0006796 5 phosphate-containing compound metabolic process 383 419 11 9 9 7 7 7 52 412 2076 0.22104 0.87591 0.47573 1.67 303872;362282;24494;24451;24450;84488;29650 pigz;pck1;il1b;hmox1;hmgcs2;fgf13;adam10 PIGZ_32744;PCK1_9439;IL1B_8892;HMOX1_8815;HMGCS2_8812;FGF13_32529;ADAM10_7983 227.7438 227.854 61.2776 99.46397000562564 213.5998130847004 109.13010956716452 140.20834285714287 148.568 39.7754 55.39318507863752 133.12715780321804 62.17909412906633 574.0011428571428 483.266 140.784 408.6412249485803 427.13574676423144 281.13822907356007 355.097;227.854;153.991;61.2776;269.456;209.76;316.771 212.48;148.568;109.464;39.7754;162.134;130.074;178.963 459.59;506.507;258.668;140.784;795.183;483.266;1374.01 5 2 5 303872;362282;24494;24451;24450 PIGZ_32744;PCK1_9439;IL1B_8892;HMOX1_8815;HMGCS2_8812 213.53512 227.854 111.91491817077834 134.48428 148.568 64.50189316130184 432.14639999999997 459.59 251.52784455860944 355.097;227.854;153.991;61.2776;269.456 212.48;148.568;109.464;39.7754;162.134 459.59;506.507;258.668;140.784;795.183 2 84488;29650 FGF13_32529;ADAM10_7983 263.2655 263.2655 75.66820376155377 154.51850000000002 154.51850000000002 34.56974342542905 928.638 928.638 629.8511227012301 209.76;316.771 130.074;178.963 483.266;1374.01 0 Exp 2,2(0.29);Linear,3(0.43);Poly 2,2(0.29) 1.9172219118488525 13.687258005142212 1.5923793315887451 2.8712503910064697 0.4491054507779831 1.8452895879745483 154.0598598670995 301.42774013290045 99.17249708430522 181.2441886299805 271.27548699157387 876.7267987227119 UP 0.7142857142857143 0.2857142857142857 0.0 GO:0044260 4 cellular macromolecule metabolic process 676 733 22 21 16 16 13 13 46 720 1768 0.15543 0.90662 0.30835 1.77 365377;360243;78968;303872;362282;25247;316273;24494;84488;316098;171142;297594;29650 trim72;top2a;srebf1;pigz;pck1;nsg1;mcm3;il1b;fgf13;exosc7;ehhadh;cdca3;adam10 TRIM72_33144;TOP2A_10059;SREBF1_32750;PIGZ_32744;PCK1_9439;NSG1_32675;MCM3_9207;IL1B_8892;FGF13_32529;EXOSC7_8580;EHHADH_8534;CDCA3_8260;ADAM10_7983 209.11498461538466 209.76 82.0928 74.0001100758398 204.63028087094878 76.18262007505493 129.0984307692308 130.074 49.3056 45.79209991849731 125.93776544343017 46.38316305924605 505.531 459.59 193.467 292.5526735356102 458.80890071183313 202.12685074233173 82.0928;203.468;177.986;355.097;227.854;216.472;229.093;153.991;209.76;111.985;250.691;183.234;316.771 49.3056;108.442;117.256;212.48;148.568;166.237;133.518;109.464;130.074;54.886;157.555;111.531;178.963 193.467;572.253;348.781;459.59;506.507;342.576;614.889;258.668;483.266;373.527;636.947;407.422;1374.01 7 6 7 365377;303872;362282;25247;24494;316098;171142 TRIM72_33144;PIGZ_32744;PCK1_9439;NSG1_32675;IL1B_8892;EXOSC7_8580;EHHADH_8534 199.7404 216.472 92.58953627230235 128.3565142857143 148.568 60.244831568509625 395.8974285714286 373.527 151.40988636243574 82.0928;355.097;227.854;216.472;153.991;111.985;250.691 49.3056;212.48;148.568;166.237;109.464;54.886;157.555 193.467;459.59;506.507;342.576;258.668;373.527;636.947 6 360243;78968;316273;84488;297594;29650 TOP2A_10059;SREBF1_32750;MCM3_9207;FGF13_32529;CDCA3_8260;ADAM10_7983 220.052 206.61399999999998 50.87705267013808 129.964 123.665 25.992346004160563 633.4368333333333 527.7595 376.08483784668414 203.468;177.986;229.093;209.76;183.234;316.771 108.442;117.256;133.518;130.074;111.531;178.963 572.253;348.781;614.889;483.266;407.422;1374.01 0 Exp 2,8(0.62);Linear,2(0.16);Poly 2,3(0.24) 1.963218823311924 26.237099647521973 1.5889767408370972 3.437419891357422 0.5470871354496332 1.8518693447113037 168.88806654722282 249.34190268354638 104.20556169508212 153.9912998433794 346.49755509190993 664.56444490809 CONFLICT 0.5384615384615384 0.46153846153846156 0.0 GO:0065003 6 protein-containing complex assembly 203 233 10 10 8 7 6 6 53 227 2261 0.70815 0.4573 0.8177 2.58 365377;25247;316273;24408;84488;29650 trim72;nsg1;mcm3;grin1;fgf13;adam10 TRIM72_33144;NSG1_32675;MCM3_9207;GRIN1_32381;FGF13_32529;ADAM10_7983 227.36896666666664 222.7825 82.0928 85.27801579825062 202.3471439234202 84.34990469253691 152.17526666666666 149.8775 49.3056 67.67201923237302 132.8939559148826 69.14396762296056 575.9029999999999 465.238 193.467 415.773249906244 468.32159000064684 258.131332649668 82.0928;216.472;229.093;310.025;209.76;316.771 49.3056;166.237;133.518;254.954;130.074;178.963 193.467;342.576;614.889;447.21;483.266;1374.01 3 3 3 365377;25247;24408 TRIM72_33144;NSG1_32675;GRIN1_32381 202.86326666666665 216.472 114.57386336513811 156.8322 166.237 103.14627381985252 327.751 342.576 127.51946118534241 82.0928;216.472;310.025 49.3056;166.237;254.954 193.467;342.576;447.21 3 316273;84488;29650 MCM3_9207;FGF13_32529;ADAM10_7983 251.87466666666668 229.093 57.02711444859642 147.51833333333332 133.518 27.286270912921484 824.055 614.889 480.8004056269087 229.093;209.76;316.771 133.518;130.074;178.963 614.889;483.266;1374.01 0 Exp 2,4(0.67);Linear,1(0.17);Poly 2,1(0.17) 1.9536346813434453 12.17976701259613 1.6434866189956665 3.437419891357422 0.6987329207686765 1.758991539478302 159.13234250564594 295.60559082768737 98.02637378551293 206.32415954782044 243.21511175013592 908.5908882498641 CONFLICT 0.5 0.5 0.0 GO:0003062 7 regulation of heart rate by chemical signal 1 1 1 1 1 1 1 1 58 0 2488 1.0 0.023165 0.023165 100.0 78968 srebf1 SREBF1_32750 177.986 177.986 177.986 177.986 117.256 117.256 117.256 117.256 348.781 348.781 348.781 348.781 0.0 177.986 0.0 177.986 177.986 117.256 348.781 0 1 0 1 78968 SREBF1_32750 177.986 177.986 117.256 117.256 348.781 348.781 177.986 117.256 348.781 0 Exp 2,1(1) 1.5889767408370972 1.5889767408370972 1.5889767408370972 1.5889767408370972 0.0 1.5889767408370972 177.986 177.986 117.256 117.256 348.781 348.781 DOWN 0.0 1.0 0.0 GO:0050804 6 modulation of chemical synaptic transmission 117 127 9 9 8 8 7 7 52 120 2368 0.99207 0.025449 0.025449 5.51 79212;29483;25247;24494;24416;24408;25311 slc6a1;slc1a3;nsg1;il1b;grm3;grin1;dcc SLC6A1_32594;SLC1A3_32817;NSG1_32675;IL1B_8892;GRM3_33234;GRIN1_32381;DCC_32537 237.79314285714287 248.198 145.445 68.38623473923317 232.0784707365903 71.56042934119085 178.5762857142857 183.659 104.722 58.24469820139367 176.7692863940095 63.088354971806325 420.2227142857143 342.576 237.101 262.02221286099274 381.79958259015626 229.4832370494611 5.5 306.73 145.445;303.435;216.472;153.991;286.986;310.025;248.198 104.722;189.179;166.237;109.464;241.819;254.954;183.659 237.101;992.735;342.576;258.668;363.86;447.21;299.409 6 1 6 79212;29483;25247;24494;24416;24408 SLC6A1_32594;SLC1A3_32817;NSG1_32675;IL1B_8892;GRM3_33234;GRIN1_32381 236.05899999999997 251.72899999999998 74.74457578981902 177.72916666666666 177.708 63.75661465735668 440.35833333333335 353.218 281.0356659605088 145.445;303.435;216.472;153.991;286.986;310.025 104.722;189.179;166.237;109.464;241.819;254.954 237.101;992.735;342.576;258.668;363.86;447.21 1 25311 DCC_32537 248.198 248.198 183.659 183.659 299.409 299.409 248.198 183.659 299.409 0 Exp 2,4(0.58);Linear,2(0.29);Poly 2,1(0.15) 2.393708507670308 17.505292654037476 1.6762725114822388 3.667783737182617 0.8131764721759489 2.0017645359039307 187.13191119551556 288.4543745187701 135.42800945819408 221.72456197037735 226.11394258830956 614.331485983119 UP 0.8571428571428571 0.14285714285714285 0.0 GO:0030855 5 epithelial cell differentiation 87 96 4 4 3 3 2 2 57 94 2394 0.61462 0.66024 1.0 2.08 362282;304729 pck1;gli2 PCK1_9439;GLI2_8713 250.7855 250.7855 227.854 32.43003830555837 263.2463629546905 27.224275442127844 156.156 156.156 148.568 10.73105251128723 160.27928142948306 9.008473150683045 669.0445 669.0445 506.507 229.8627368942172 757.3665684428845 192.96451037546004 227.854;273.717 148.568;163.744 506.507;831.582 1 1 1 362282 PCK1_9439 227.854 227.854 148.568 148.568 506.507 506.507 227.854 148.568 506.507 1 304729 GLI2_8713 273.717 273.717 163.744 163.744 831.582 831.582 273.717 163.744 831.582 0 Exp 2,1(0.5);Linear,1(0.5) 2.1804215376857767 4.3609864711761475 2.162810802459717 2.1981756687164307 0.02500673674587769 2.1804932355880737 205.83976000000004 295.73123999999996 141.28352 171.02848 350.471 987.6179999999999 CONFLICT 0.5 0.5 0.0 GO:0010038 5 response to metal ion 201 215 10 10 8 9 7 7 52 208 2280 0.88058 0.22622 0.33876 3.26 79212;24567;24451;24450;24408;24232;298566 slc6a1;mt1;hmox1;hmgcs2;grin1;c3;c1qa SLC6A1_32594;MT1A_9255;HMOX1_8815;HMGCS2_8812;GRIN1_32381;C3_8175;C1QA_8167 227.3900857142857 268.455 61.2776 114.62871300762632 217.38990296720164 112.25167555237367 141.7752857142857 161.753 39.7754 78.86334683124201 136.88204461688764 75.03873047594661 1310.1378571428572 447.21 140.784 2353.5242326874695 1205.588703196092 2269.8597267957666 145.445;392.753;61.2776;269.456;310.025;144.319;268.455 104.722;211.395;39.7754;162.134;254.954;57.6936;161.753 237.101;6610.49;140.784;795.183;447.21;153.26;786.937 7 0 7 79212;24567;24451;24450;24408;24232;298566 SLC6A1_32594;MT1A_9255;HMOX1_8815;HMGCS2_8812;GRIN1_32381;C3_8175;C1QA_8167 227.3900857142857 268.455 114.62871300762632 141.7752857142857 161.753 78.86334683124201 1310.1378571428572 447.21 2353.5242326874695 145.445;392.753;61.2776;269.456;310.025;144.319;268.455 104.722;211.395;39.7754;162.134;254.954;57.6936;161.753 237.101;6610.49;140.784;795.183;447.21;153.26;786.937 0 0 Exp 2,2(0.29);Exp 5,1(0.15);Linear,3(0.43);Poly 2,1(0.15) 1.8621824560940916 13.075339436531067 1.5923793315887451 2.0174295902252197 0.1540778498039828 1.912996768951416 142.471946751125 312.30822467744645 83.35250079764974 200.19807063092173 -433.3772936485864 3053.653007934301 UP 1.0 0.0 0.0 GO:0045664 8 regulation of neuron differentiation 157 165 9 9 9 8 8 8 51 157 2331 0.98778 0.034052 0.052388 4.85 338475;25595;24494;24408;304729;84488;25311;29650 nrep;map2;il1b;grin1;gli2;fgf13;dcc;adam10 NREP_9364;MAP2_32650;IL1B_8892;GRIN1_32381;GLI2_8713;FGF13_32529;DCC_32537;ADAM10_7983 234.990625 235.11200000000002 145.437 64.78294636914768 235.76085198261808 57.28469363074034 158.544125 153.26049999999998 104.718 48.894713051726896 162.91218620994022 49.91068700642885 553.620875 465.238 237.081 382.0087349302137 485.1708548003802 276.4307110876178 222.026;145.437;153.991;310.025;273.717;209.76;248.198;316.771 142.777;104.718;109.464;254.954;163.744;130.074;183.659;178.963 497.741;237.081;258.668;447.21;831.582;483.266;299.409;1374.01 3 5 3 25595;24494;24408 MAP2_32650;IL1B_8892;GRIN1_32381 203.15099999999998 153.991 92.6543665241957 156.37866666666667 109.464 85.40171769544997 314.3196666666667 258.668 115.59143637109665 145.437;153.991;310.025 104.718;109.464;254.954 237.081;258.668;447.21 5 338475;304729;84488;25311;29650 NREP_9364;GLI2_8713;FGF13_32529;DCC_32537;ADAM10_7983 254.0944 248.198 42.843002500992014 159.8434 163.744 23.051224334078178 697.2016 497.741 424.24038784903547 222.026;273.717;209.76;248.198;316.771 142.777;163.744;130.074;183.659;178.963 497.741;831.582;483.266;299.409;1374.01 0 Exp 2,2(0.25);Linear,5(0.63);Poly 2,1(0.13) 1.9496282845802972 15.888102531433105 1.5347857475280762 2.8712503910064697 0.42766676011941823 1.9254007935523987 190.0983335307887 279.88291646921135 124.66181750021445 192.42643249978556 288.9023273971847 818.3394226028154 DOWN 0.375 0.625 0.0 GO:0050776 5 regulation of immune response 176 199 9 8 7 5 5 5 54 194 2294 0.68797 0.49445 0.80491 2.51 294228;24494;24451;24232;298566 rt1-s3;il1b;hmox1;c3;c1qa RT1-S3_9763;IL1B_8892;HMOX1_8815;C3_8175;C1QA_8167 169.44991999999996 153.991 61.2776 78.81872404087758 186.0311134860051 77.630884925841 102.0444 109.464 39.7754 52.49803727359718 113.7679767860638 51.17149667634171 364.843 258.668 140.784 273.28550709834576 423.42911880994325 276.7250573658937 219.207;153.991;61.2776;144.319;268.455 141.536;109.464;39.7754;57.6936;161.753 484.566;258.668;140.784;153.26;786.937 4 1 4 24494;24451;24232;298566 IL1B_8892;HMOX1_8815;C3_8175;C1QA_8167 157.01065 149.155 85.15643697546686 92.1715 83.5788 54.99906842277724 334.91225 205.964 305.95363355076654 153.991;61.2776;144.319;268.455 109.464;39.7754;57.6936;161.753 258.668;140.784;153.26;786.937 1 294228 RT1-S3_9763 219.207 219.207 141.536 141.536 484.566 484.566 219.207 141.536 484.566 0 Exp 5,1(0.2);Linear,3(0.6);Poly 2,1(0.2) 1.9530501306497097 9.991951704025269 1.5923793315887451 2.8712503910064697 0.5115897713148451 1.7851157188415527 100.362262256762 238.537577743238 56.027841428600226 148.06095857139977 125.2976913141382 604.3883086858618 UP 0.8 0.2 0.0 GO:0045329 7 carnitine biosynthetic process 2 2 1 1 1 1 1 1 58 1 2487 0.99947 0.045801 0.045801 50.0 64564 bbox1 BBOX1_8133 454.248 454.248 454.248 454.248 259.457 259.457 259.457 259.457 491.171 491.171 491.171 491.171 0.0 454.248 0.0 454.248 454.248 259.457 491.171 1 0 1 64564 BBOX1_8133 454.248 454.248 259.457 259.457 491.171 491.171 454.248 259.457 491.171 0 0 Power,1(1) 2.7777180671691895 2.7777180671691895 2.7777180671691895 2.7777180671691895 0.0 2.7777180671691895 454.248 454.248 259.457 259.457 491.171 491.171 UP 1.0 0.0 0.0 GO:0050793 4 regulation of developmental process 584 616 22 22 20 16 15 15 44 601 1887 0.65536 0.46168 0.8777 2.44 29142;365377;311715;338475;25595;24494;24451;24408;304729;84488;25311;245920;502902;24232;29650 vnn1;trim72;tcfl5;nrep;map2;il1b;hmox1;grin1;gli2;fgf13;dcc;cxcl10;clec7a;c3;adam10 VNN1_10157;TRIM72_33144;TCFL5_9994;NREP_9364;MAP2_32650;IL1B_8892;HMOX1_8815;GRIN1_32381;GLI2_8713;FGF13_32529;DCC_32537;CXCL10_8408;CLEC7A_32927;C3_8175;ADAM10_7983 228.62249333333335 233.741 61.2776 98.35031700629757 229.6067526302851 109.94481346375693 154.5345066666667 147.819 39.7754 80.6379082370379 156.50706831059486 91.09991684473107 556.9074 447.21 140.784 519.565302121852 559.9627341599065 569.9902170427732 233.741;82.0928;270.921;222.026;145.437;153.991;61.2776;310.025;273.717;209.76;248.198;344.076;412.985;144.319;316.771 147.819;49.3056;228.673;142.777;104.718;109.464;39.7754;254.954;163.744;130.074;183.659;187.725;338.673;57.6936;178.963 556.851;193.467;338.867;497.741;237.081;258.668;140.784;447.21;831.582;483.266;299.409;2052.67;488.745;153.26;1374.01 9 6 9 29142;365377;311715;25595;24494;24451;24408;502902;24232 VNN1_10157;TRIM72_33144;TCFL5_9994;MAP2_32650;IL1B_8892;HMOX1_8815;GRIN1_32381;CLEC7A_32927;C3_8175 201.64326666666668 153.991 114.53841393205164 147.89728888888888 109.464 104.44506398481029 312.7703333333333 258.668 152.974500907831 233.741;82.0928;270.921;145.437;153.991;61.2776;310.025;412.985;144.319 147.819;49.3056;228.673;104.718;109.464;39.7754;254.954;338.673;57.6936 556.851;193.467;338.867;237.081;258.668;140.784;447.21;488.745;153.26 6 338475;304729;84488;25311;245920;29650 NREP_9364;GLI2_8713;FGF13_32529;DCC_32537;CXCL10_8408;ADAM10_7983 269.09133333333335 260.9575 53.083578883367366 164.49033333333333 171.3535 23.551031634870277 923.1129999999999 664.6614999999999 670.9692163174104 222.026;273.717;209.76;248.198;344.076;316.771 142.777;163.744;130.074;183.659;187.725;178.963 497.741;831.582;483.266;299.409;2052.67;1374.01 0 Exp 2,3(0.2);Exp 5,1(0.07);Linear,7(0.47);Poly 2,4(0.27) 1.9191697928692844 29.216922163963318 1.5347857475280762 2.8712503910064697 0.36391528318185773 1.9169143438339233 178.85036572501085 278.39462094165583 113.7260946451268 195.3429186882065 293.97107904833945 819.8437209516607 UP 0.6 0.4 0.0 GO:0001817 5 regulation of cytokine production 196 207 7 7 6 5 5 5 54 202 2286 0.65415 0.53059 0.81088 2.42 294228;24494;24451;502902;24232 rt1-s3;il1b;hmox1;clec7a;c3 RT1-S3_9763;IL1B_8892;HMOX1_8815;CLEC7A_32927;C3_8175 198.35592 153.991 61.2776 132.45670064452005 215.66411348470027 131.8853345808423 137.4284 109.464 39.7754 119.57426125040455 151.85015253871325 119.77703202889245 305.2046 258.668 140.784 171.86080163550957 344.05591130528654 172.58786299487127 219.207;153.991;61.2776;412.985;144.319 141.536;109.464;39.7754;338.673;57.6936 484.566;258.668;140.784;488.745;153.26 4 1 4 24494;24451;502902;24232 IL1B_8892;HMOX1_8815;CLEC7A_32927;C3_8175 193.14315 149.155 152.35446690866448 136.4015 83.5788 138.047003278014 260.36424999999997 205.964 161.17423366525853 153.991;61.2776;412.985;144.319 109.464;39.7754;338.673;57.6936 258.668;140.784;488.745;153.26 1 294228 RT1-S3_9763 219.207 219.207 141.536 141.536 484.566 484.566 219.207 141.536 484.566 0 Exp 5,1(0.2);Linear,2(0.4);Poly 2,2(0.4) 1.9687545401721847 10.074377059936523 1.5923793315887451 2.8712503910064697 0.5136803874280826 1.7851157188415527 82.25250280713709 314.4593371928629 32.616938806032366 242.23986119396767 154.56196543115416 455.8472345688458 UP 0.8 0.2 0.0 GO:0010832 9 negative regulation of myotube differentiation 9 9 2 2 2 2 2 2 57 7 2481 0.9991 0.017107 0.017107 22.22 365377;245920 trim72;cxcl10 TRIM72_33144;CXCL10_8408 213.08440000000002 213.08440000000002 82.0928 185.25009727695155 203.71219765690378 184.77532894734657 118.5153 118.5153 49.3056 97.87729638777319 113.56347627615064 97.62645149648657 1123.0685 1123.0685 193.467 1314.6550489023728 1056.5572629707112 1311.2857843743168 0.0 82.0928 0.0 82.0928 82.0928;344.076 49.3056;187.725 193.467;2052.67 1 1 1 365377 TRIM72_33144 82.0928 82.0928 49.3056 49.3056 193.467 193.467 82.0928 49.3056 193.467 1 245920 CXCL10_8408 344.076 344.076 187.725 187.725 2052.67 2052.67 344.076 187.725 2052.67 0 Linear,1(0.5);Poly 2,1(0.5) 2.028762616177403 4.136459946632385 1.6661137342453003 2.470346212387085 0.5686782389445177 2.0682299733161926 -43.65913599999993 469.82793599999997 -17.135711999999984 254.16631199999998 -698.9504399999998 2945.0874400000002 CONFLICT 0.5 0.5 0.0 GO:0034762 5 regulation of transmembrane transport 122 128 4 4 4 3 3 3 56 125 2363 0.65555 0.57708 1.0 2.34 24494;245920;24232 il1b;cxcl10;c3 IL1B_8892;CXCL10_8408;C3_8175 214.12866666666665 153.991 144.319 112.64155084307635 230.36170395353196 117.57700139320545 118.2942 109.464 57.6936 65.46388752984346 127.75338381112985 66.51790007939482 821.5326666666666 258.668 153.26 1067.4980382939038 975.5587787146337 1113.9654747710888 153.991;344.076;144.319 109.464;187.725;57.6936 258.668;2052.67;153.26 2 1 2 24494;24232 IL1B_8892;C3_8175 149.155 149.155 6.839136787636285 83.5788 83.5788 36.607200904740054 205.964 205.964 74.5347115913116 153.991;144.319 109.464;57.6936 258.668;153.26 1 245920 CXCL10_8408 344.076 344.076 187.725 187.725 2052.67 2052.67 344.076 187.725 2052.67 0 Exp 5,1(0.34);Linear,2(0.67) 2.3046474262255012 7.067373275756836 1.7257766723632812 2.8712503910064697 0.5812655733351719 2.470346212387085 86.66275245234016 341.5945808809932 44.21483754839312 192.37356245160686 -386.45508167936396 2029.520415012697 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0042221 3 response to chemical 909 981 40 40 35 30 27 27 32 954 1534 0.90104 0.15344 0.27909 2.75 360243;78968;79212;29483;362282;24567;58827;25595;361680;681410;24503;24494;24451;24450;24408;304729;84488;25315;25311;25086;25279;245920;502902;24232;298566;29650;170924 top2a;srebf1;slc6a1;slc1a3;pck1;mt1;mest;map2;lsp1;loc681410;ina;il1b;hmox1;hmgcs2;grin1;gli2;fgf13;ephx1;dcc;cyp2e1;cyp24a1;cxcl10;clec7a;c3;c1qa;adam10;abcc4 TOP2A_10059;SREBF1_32750;SLC6A1_32594;SLC1A3_32817;PCK1_9439;MT1A_9255;MEST_9219;MAP2_32650;LSP1_32853;LOC681410_33126;INA_32322;IL1B_8892;HMOX1_8815;HMGCS2_8812;GRIN1_32381;GLI2_8713;FGF13_32529;EPHX1_8567;DCC_32537;CYP2E1_8421;CYP24A1_32574;CXCL10_8408;CLEC7A_32927;C3_8175;C1QA_8167;ADAM10_7983;ABCC4_32768 245.66862962962963 248.198 12.5094 99.26737002843468 248.87189018858425 94.7374345666291 160.891 161.753 3.282 75.82299296720366 164.40008169143772 73.7318348671647 864.8423555555556 495.344 61.3966 1280.7508649935178 878.7077004230331 1329.4670976160846 203.468;177.986;145.445;303.435;227.854;392.753;272.228;145.437;231.535;410.591;305.642;153.991;61.2776;269.456;310.025;273.717;209.76;12.5094;248.198;357.376;189.111;344.076;412.985;144.319;268.455;316.771;244.652 108.442;117.256;104.722;189.179;148.568;211.395;198.842;104.718;141.502;326.66;249.176;109.464;39.7754;162.134;254.954;163.744;130.074;3.282;183.659;191.769;127.579;187.725;338.673;57.6936;161.753;178.963;152.355 572.253;348.781;237.101;992.735;506.507;6610.49;543.288;237.081;580.905;495.344;459.059;258.668;140.784;795.183;447.21;831.582;483.266;61.3966;299.409;2610.68;364.247;2052.67;488.745;153.26;786.937;1374.01;619.152 19 8 19 79212;29483;362282;24567;58827;25595;681410;24503;24494;24451;24450;24408;25315;25086;25279;502902;24232;298566;170924 SLC6A1_32594;SLC1A3_32817;PCK1_9439;MT1A_9255;MEST_9219;MAP2_32650;LOC681410_33126;INA_32322;IL1B_8892;HMOX1_8815;HMGCS2_8812;GRIN1_32381;EPHX1_8567;CYP2E1_8421;CYP24A1_32574;CLEC7A_32927;C3_8175;C1QA_8167;ABCC4_32768 243.55484210526313 268.455 113.70910708950038 164.8785263157895 161.753 88.7009526630091 884.6246105263157 488.745 1492.049312067442 145.445;303.435;227.854;392.753;272.228;145.437;410.591;305.642;153.991;61.2776;269.456;310.025;12.5094;357.376;189.111;412.985;144.319;268.455;244.652 104.722;189.179;148.568;211.395;198.842;104.718;326.66;249.176;109.464;39.7754;162.134;254.954;3.282;191.769;127.579;338.673;57.6936;161.753;152.355 237.101;992.735;506.507;6610.49;543.288;237.081;495.344;459.059;258.668;140.784;795.183;447.21;61.3966;2610.68;364.247;488.745;153.26;786.937;619.152 8 360243;78968;361680;304729;84488;25311;245920;29650 TOP2A_10059;SREBF1_32750;LSP1_32853;GLI2_8713;FGF13_32529;DCC_32537;CXCL10_8408;ADAM10_7983 250.68887499999997 239.8665 57.54757555384083 151.420625 152.623 31.250622366088297 817.8595 576.579 603.7380007484325 203.468;177.986;231.535;273.717;209.76;248.198;344.076;316.771 108.442;117.256;141.502;163.744;130.074;183.659;187.725;178.963 572.253;348.781;580.905;831.582;483.266;299.409;2052.67;1374.01 0 Exp 2,10(0.38);Exp 5,1(0.04);Hill,1(0.04);Linear,11(0.41);Poly 2,4(0.15) 1.9258134558402755 52.55148422718048 1.5415009260177612 2.8712503910064697 0.2990424487571113 1.9169143438339233 208.2247616619565 283.1124975973027 132.2904020717529 189.49159792824702 381.7403425319047 1347.9443685792064 UP 0.7037037037037037 0.2962962962962963 0.0 GO:0042493 4 response to drug 436 472 21 21 18 17 15 15 44 457 2031 0.93455 0.11559 0.17506 3.18 360243;78968;79212;29483;362282;25595;24494;24451;24450;24408;25311;25086;24232;29650;170924 top2a;srebf1;slc6a1;slc1a3;pck1;map2;il1b;hmox1;hmgcs2;grin1;dcc;cyp2e1;c3;adam10;abcc4 TOP2A_10059;SREBF1_32750;SLC6A1_32594;SLC1A3_32817;PCK1_9439;MAP2_32650;IL1B_8892;HMOX1_8815;HMGCS2_8812;GRIN1_32381;DCC_32537;CYP2E1_8421;C3_8175;ADAM10_7983;ABCC4_32768 220.64604000000006 227.854 61.2776 82.65290377300535 207.81592812064554 83.98645351807119 140.24346666666668 148.568 39.7754 56.19268226561007 135.69765103448276 59.76400379579872 639.5209333333333 447.21 140.784 642.9781100687937 549.7820915777404 632.243006269031 203.468;177.986;145.445;303.435;227.854;145.437;153.991;61.2776;269.456;310.025;248.198;357.376;144.319;316.771;244.652 108.442;117.256;104.722;189.179;148.568;104.718;109.464;39.7754;162.134;254.954;183.659;191.769;57.6936;178.963;152.355 572.253;348.781;237.101;992.735;506.507;237.081;258.668;140.784;795.183;447.21;299.409;2610.68;153.26;1374.01;619.152 11 4 11 79212;29483;362282;25595;24494;24451;24450;24408;25086;24232;170924 SLC6A1_32594;SLC1A3_32817;PCK1_9439;MAP2_32650;IL1B_8892;HMOX1_8815;HMGCS2_8812;GRIN1_32381;CYP2E1_8421;C3_8175;ABCC4_32768 214.8425090909091 227.854 91.19016495352386 137.75745454545455 148.568 62.62171751225548 636.2146363636363 447.21 710.1807271992494 145.445;303.435;227.854;145.437;153.991;61.2776;269.456;310.025;357.376;144.319;244.652 104.722;189.179;148.568;104.718;109.464;39.7754;162.134;254.954;191.769;57.6936;152.355 237.101;992.735;506.507;237.081;258.668;140.784;795.183;447.21;2610.68;153.26;619.152 4 360243;78968;25311;29650 TOP2A_10059;SREBF1_32750;DCC_32537;ADAM10_7983 236.60575 225.833 60.814562764604254 147.07999999999998 148.1095 39.736276247278155 648.6132500000001 460.51700000000005 497.9539199058314 203.468;177.986;248.198;316.771 108.442;117.256;183.659;178.963 572.253;348.781;299.409;1374.01 0 Exp 2,5(0.34);Exp 5,1(0.07);Linear,7(0.47);Poly 2,2(0.14) 1.8808936550397999 28.57840323448181 1.5415009260177612 2.8712503910064697 0.33613535168726166 1.9080781936645508 178.81789954240477 262.4741804575952 111.80604584779147 168.6808874855419 314.1291143964118 964.9127522702547 UP 0.7333333333333333 0.26666666666666666 0.0 GO:0032879 4 regulation of localization 652 690 22 22 19 17 14 14 45 676 1812 0.33672 0.76595 0.65723 2.03 366669;78968;79212;294228;58827;25595;24494;24451;24408;245920;502902;363198;24232;29650 syne2;srebf1;slc6a1;rt1-s3;mest;map2;il1b;hmox1;grin1;cxcl10;clec7a;cenpq;c3;adam10 SYNE2_9977;SREBF1_32750;SLC6A1_32594;RT1-S3_9763;MEST_9219;MAP2_32650;IL1B_8892;HMOX1_8815;GRIN1_32381;CXCL10_8408;CLEC7A_32927;CENPQ_8290;C3_8175;ADAM10_7983 215.74829285714287 198.5965 39.9715 109.67609334350404 207.62898308378777 117.25606335013548 143.6699642857143 129.39600000000002 12.1775 86.5907113695726 139.1707999773355 94.07466703840282 557.3198571428571 397.9955 140.784 543.153647382064 528.2148370706141 557.8691315567512 276.757;177.986;145.445;219.207;272.228;145.437;153.991;61.2776;310.025;344.076;412.985;39.9715;144.319;316.771 164.88;117.256;104.722;141.536;198.842;104.718;109.464;39.7754;254.954;187.725;338.673;12.1775;57.6936;178.963 858.911;348.781;237.101;484.566;543.288;237.081;258.668;140.784;447.21;2052.67;488.745;177.403;153.26;1374.01 8 6 8 79212;58827;25595;24494;24451;24408;502902;24232 SLC6A1_32594;MEST_9219;MAP2_32650;IL1B_8892;HMOX1_8815;GRIN1_32381;CLEC7A_32927;C3_8175 205.71345000000002 149.71800000000002 115.16343780194673 151.10525 107.09299999999999 103.78705494467296 313.267125 247.8845 156.5622461628395 145.445;272.228;145.437;153.991;61.2776;310.025;412.985;144.319 104.722;198.842;104.718;109.464;39.7754;254.954;338.673;57.6936 237.101;543.288;237.081;258.668;140.784;447.21;488.745;153.26 6 366669;78968;294228;245920;363198;29650 SYNE2_9977;SREBF1_32750;RT1-S3_9763;CXCL10_8408;CENPQ_8290;ADAM10_7983 229.1280833333333 247.982 111.0468114726473 133.75625 153.208 64.8677720410914 882.7235000000001 671.7384999999999 714.3955863432386 276.757;177.986;219.207;344.076;39.9715;316.771 164.88;117.256;141.536;187.725;12.1775;178.963 858.911;348.781;484.566;2052.67;177.403;1374.01 0 Exp 2,3(0.22);Exp 4,1(0.08);Exp 5,1(0.08);Linear,7(0.5);Poly 2,2(0.15) 1.9472582696256395 27.649822235107422 1.5889767408370972 2.8712503910064697 0.36094424633885236 1.9080458283424377 158.29644178357063 273.2001439307151 98.31097581063827 189.0289527607903 272.7985771796139 841.8411371061004 CONFLICT 0.5714285714285714 0.42857142857142855 0.0 GO:0030154 4 cell differentiation 405 432 17 16 16 10 9 9 50 423 2065 0.44384 0.69181 0.86114 2.08 246118;360243;78968;362282;24503;304729;80841;25279;24232 tubb3;top2a;srebf1;pck1;ina;gli2;fabp7;cyp24a1;c3 TUBB3_32820;TOP2A_10059;SREBF1_32750;PCK1_9439;INA_32322;GLI2_8713;FABP7_8592;CYP24A1_32574;C3_8175 225.81866666666667 227.854 144.319 53.19676149447433 229.01439535881173 55.531404397815585 156.1762888888889 148.568 57.6936 62.554351888986176 163.45912255807127 65.13573637596886 429.35211111111107 364.247 153.26 195.47219047504214 410.77721634799883 187.06537185381288 282.273;203.468;177.986;227.854;305.642;273.717;227.998;189.111;144.319 238.208;108.442;117.256;148.568;249.176;163.744;194.92;127.579;57.6936 354.06;572.253;348.781;506.507;459.059;831.582;274.42;364.247;153.26 6 3 6 246118;362282;24503;80841;25279;24232 TUBB3_32820;PCK1_9439;INA_32322;FABP7_8592;CYP24A1_32574;C3_8175 229.53283333333331 227.926 59.11789344493493 169.35743333333332 171.744 72.67915606889414 351.9255 359.1535 127.28274497157899 282.273;227.854;305.642;227.998;189.111;144.319 238.208;148.568;249.176;194.92;127.579;57.6936 354.06;506.507;459.059;274.42;364.247;153.26 3 360243;78968;304729 TOP2A_10059;SREBF1_32750;GLI2_8713 218.3903333333333 203.468 49.57936177819692 129.814 117.256 29.71288144896082 584.2053333333333 572.253 241.6223191353262 203.468;177.986;273.717 108.442;117.256;163.744 572.253;348.781;831.582 0 Exp 2,6(0.67);Exp 5,1(0.12);Linear,2(0.23) 2.2263505453225108 21.449904322624207 1.5889767408370972 5.283818244934082 1.128251082605509 2.1550474166870117 191.06344915694336 260.57388417639 115.30744565475126 197.04513212302655 301.6436133340837 557.0606088881386 UP 0.6666666666666666 0.3333333333333333 0.0 GO:1901568 4 fatty acid derivative metabolic process 46 57 5 5 5 4 4 4 55 53 2435 0.99064 0.041221 0.041221 7.02 24450;25315;50549;25086 hmgcs2;ephx1;cyp4a1;cyp2e1 HMGCS2_8812;EPHX1_8567;CYP4A1_33111;CYP2E1_8421 253.7366 313.416 12.5094 167.36257417865758 317.29183321185855 125.1024006889775 138.56925 176.9515 3.282 91.49328413012982 170.545518368955 66.48233215056203 1858.4949 1702.9315 61.3966 1767.3511246567577 2631.7652539544956 1559.934405262512 1.5 313.416 269.456;12.5094;375.605;357.376 162.134;3.282;197.092;191.769 795.183;61.3966;3966.72;2610.68 4 0 4 24450;25315;50549;25086 HMGCS2_8812;EPHX1_8567;CYP4A1_33111;CYP2E1_8421 253.7366 313.416 167.36257417865758 138.56925 176.9515 91.49328413012982 1858.4949 1702.9315 1767.3511246567577 269.456;12.5094;375.605;357.376 162.134;3.282;197.092;191.769 795.183;61.3966;3966.72;2610.68 0 0 Hill,1(0.25);Linear,3(0.75) 1.8402017935889152 7.399422764778137 1.5810112953186035 2.1014184951782227 0.21650802255716237 1.8584964871406555 89.72127730491559 417.75192269508443 48.90583155247279 228.23266844752723 126.49079783637762 3590.499002163622 UP 1.0 0.0 0.0 GO:0032880 5 regulation of protein localization 255 275 8 8 8 6 6 6 53 269 2219 0.54325 0.62595 1.0 2.18 78968;294228;25595;24494;363198;29650 srebf1;rt1-s3;map2;il1b;cenpq;adam10 SREBF1_32750;RT1-S3_9763;MAP2_32650;IL1B_8892;CENPQ_8290;ADAM10_7983 175.5605833333333 165.9885 39.9715 91.22318874738849 150.8462796809986 85.97484082959075 110.68575 113.36 12.1775 55.493550992660396 94.95535062413315 60.370805379353136 480.08483333333334 303.72450000000003 177.403 450.7894298740452 360.66739722607485 258.2506513453281 177.986;219.207;145.437;153.991;39.9715;316.771 117.256;141.536;104.718;109.464;12.1775;178.963 348.781;484.566;237.081;258.668;177.403;1374.01 2 4 2 25595;24494 MAP2_32650;IL1B_8892 149.714 149.714 6.048591406270443 107.09100000000001 107.09100000000001 3.3559287835111813 247.8745 247.8745 15.264314085473336 145.437;153.991 104.718;109.464 237.081;258.668 4 78968;294228;363198;29650 SREBF1_32750;RT1-S3_9763;CENPQ_8290;ADAM10_7983 188.483875 198.5965 114.84428262969449 112.483125 129.39600000000002 71.525384930078 596.19 416.6735 533.5596294154946 177.986;219.207;39.9715;316.771 117.256;141.536;12.1775;178.963 348.781;484.566;177.403;1374.01 0 Exp 2,1(0.17);Exp 4,1(0.17);Linear,4(0.67) 1.9443720871738825 11.913646221160889 1.5889767408370972 2.8712503910064697 0.47455285524845714 1.8421465158462524 102.56683005403737 248.5543366126293 66.28166124393529 155.08983875606475 119.37816568702686 840.7915009796397 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0019233 6 sensory perception of pain 16 17 2 2 2 2 2 2 57 15 2473 0.99363 0.05742 0.05742 11.76 24416;24408 grm3;grin1 GRM3_33234;GRIN1_32381 298.5055 298.5055 286.986 16.29103313175765 294.7677756006531 15.409626638211346 248.3865 248.3865 241.819 9.28784757088496 246.25554770235595 8.78533989725605 405.53499999999997 405.53499999999997 363.86 58.93735021189937 392.0127408444134 55.74861670623134 0.0 286.986 0.5 298.5055 286.986;310.025 241.819;254.954 363.86;447.21 2 0 2 24416;24408 GRM3_33234;GRIN1_32381 298.5055 298.5055 16.29103313175765 248.3865 248.3865 9.28784757088496 405.53499999999997 405.53499999999997 58.93735021189937 286.986;310.025 241.819;254.954 363.86;447.21 0 0 Exp 2,2(1) 2.6515707148567906 5.5846980810165405 1.9169143438339233 3.667783737182617 1.2380516210088381 2.7923490405082703 275.92728 321.08371999999997 235.5142 261.2588 323.85200000000003 487.2179999999999 UP 1.0 0.0 0.0 GO:0007409 9 axonogenesis 28 30 3 3 3 3 3 3 56 27 2461 0.99546 0.030767 0.030767 10.0 25595;304729;25311 map2;gli2;dcc MAP2_32650;GLI2_8713;DCC_32537 222.45066666666665 248.198 145.437 67.90532733396802 249.91956551141166 41.68835748752417 150.707 163.744 104.718 41.053536960900274 168.82327066779374 26.563524004146444 456.02400000000006 299.409 237.081 326.7323880777661 511.71718402366866 326.4617727216069 0.5 196.8175 2.0 273.717 145.437;273.717;248.198 104.718;163.744;183.659 237.081;831.582;299.409 1 2 1 25595 MAP2_32650 145.437 145.437 104.718 104.718 237.081 237.081 145.437 104.718 237.081 2 304729;25311 GLI2_8713;DCC_32537 260.9575 260.9575 18.044657949100255 173.7015 173.7015 14.082031547329832 565.4955 565.4955 376.30313706438864 273.717;248.198 163.744;183.659 831.582;299.409 0 Linear,2(0.67);Poly 2,1(0.34) 2.0828646444071928 6.257702350616455 1.933887243270874 2.1981756687164307 0.13655205413106816 2.1256394386291504 145.60855499594166 299.2927783373917 104.2505495934985 197.16345040650148 86.29149686905157 825.7565031309484 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0051171 5 regulation of nitrogen compound metabolic process 917 985 26 26 22 17 15 15 44 970 1518 0.021773 0.98947 0.041669 1.52 360243;311715;313506;78968;291773;362282;681410;24494;24451;24408;304729;84488;25311;502902;24232 top2a;tcfl5;stil;srebf1;taf4b;pck1;loc681410;il1b;hmox1;grin1;gli2;fgf13;dcc;clec7a;c3 TOP2A_10059;TCFL5_9994;STIL_33274;SREBF1_32750;RGD1562997_32695;PCK1_9439;LOC681410_33126;IL1B_8892;HMOX1_8815;GRIN1_32381;GLI2_8713;FGF13_32529;DCC_32537;CLEC7A_32927;C3_8175 246.44204 248.198 61.2776 95.2164991008596 245.78843685092127 99.56967135732472 170.06153333333333 163.744 39.7754 86.93465994923737 171.0664078474132 90.52699759811009 502.60186666666675 483.266 140.784 302.7755617735133 487.8167930217122 311.2390320220776 203.468;270.921;311.636;177.986;279.902;227.854;410.591;153.991;61.2776;310.025;273.717;209.76;248.198;412.985;144.319 108.442;228.673;177.242;117.256;166.045;148.568;326.66;109.464;39.7754;254.954;163.744;130.074;183.659;338.673;57.6936 572.253;338.867;1285.89;348.781;888.462;506.507;495.344;258.668;140.784;447.21;831.582;483.266;299.409;488.745;153.26 8 7 8 311715;362282;681410;24494;24451;24408;502902;24232 TCFL5_9994;PCK1_9439;LOC681410_33126;IL1B_8892;HMOX1_8815;GRIN1_32381;CLEC7A_32927;C3_8175 248.99545 249.3875 126.98649355971462 188.057625 188.6205 116.3364141831752 353.673125 393.0385 153.60188982323044 270.921;227.854;410.591;153.991;61.2776;310.025;412.985;144.319 228.673;148.568;326.66;109.464;39.7754;254.954;338.673;57.6936 338.867;506.507;495.344;258.668;140.784;447.21;488.745;153.26 7 360243;313506;78968;291773;304729;84488;25311 TOP2A_10059;STIL_33274;SREBF1_32750;RGD1562997_32695;GLI2_8713;FGF13_32529;DCC_32537 243.52385714285714 248.198 48.19368428341558 149.49457142857142 163.744 30.320203868362224 672.8061428571428 572.253 350.7238128049993 203.468;311.636;177.986;279.902;273.717;209.76;248.198 108.442;177.242;117.256;166.045;163.744;130.074;183.659 572.253;1285.89;348.781;888.462;831.582;483.266;299.409 0 Exp 2,6(0.4);Exp 5,1(0.07);Linear,4(0.27);Poly 2,4(0.27) 1.8874810029328768 28.684645771980286 1.5889767408370972 2.8712503910064697 0.3402380473892736 1.84465754032135 198.25584306723113 294.6282369327689 126.0665252816308 214.05654138503587 349.37629143737814 655.8274418959554 CONFLICT 0.5333333333333333 0.4666666666666667 0.0 GO:0031640 4 killing of cells of other organism 20 23 2 2 2 2 2 2 57 21 2467 0.98496 0.097858 0.097858 8.7 25211;245920 lyz2;cxcl10 LYZ2_32611;CXCL10_8408 279.3955 279.3955 214.715 91.47204032107292 288.10482248167716 90.63900685863845 163.63049999999998 163.63049999999998 139.536 34.0747686785987 166.8748591273223 33.76445065754689 1258.5005 1258.5005 464.331 1123.1252777230593 1365.4365669848303 1112.8970053945386 0.5 279.3955 214.715;344.076 139.536;187.725 464.331;2052.67 1 1 1 25211 LYZ2_32611 214.715 214.715 139.536 139.536 464.331 464.331 214.715 139.536 464.331 1 245920 CXCL10_8408 344.076 344.076 187.725 187.725 2052.67 2052.67 344.076 187.725 2052.67 0 Linear,2(1) 1.9645064157651377 4.032590985298157 1.5622447729110718 2.470346212387085 0.642124685858754 2.0162954926490784 152.62172000000004 406.16928 116.40527999999998 210.85572 -298.0717199999999 2815.07272 CONFLICT 0.5 0.5 0.0 GO:0006635 7 fatty acid beta-oxidation 29 33 2 2 2 2 2 2 57 31 2457 0.96062 0.17686 0.17686 6.06 171142;29740 ehhadh;eci1 EHHADH_8534;ECI1_8520 223.2245 223.2245 195.758 38.84349681092073 238.19315116955664 32.5683313792441 144.16649999999998 144.16649999999998 130.778 18.934198279832433 151.46294425695334 15.875379268236333 512.4739999999999 512.4739999999999 388.001 176.03140474926673 580.3091052019086 147.59353801061917 0.5 223.2245 250.691;195.758 157.555;130.778 636.947;388.001 2 0 2 171142;29740 EHHADH_8534;ECI1_8520 223.2245 223.2245 38.84349681092073 144.16649999999998 144.16649999999998 18.934198279832433 512.4739999999999 512.4739999999999 176.03140474926673 250.691;195.758 157.555;130.778 636.947;388.001 0 0 Exp 2,1(0.5);Linear,1(0.5) 1.5661576487309063 3.133363962173462 1.5261523723602295 1.6072115898132324 0.05731752233869332 1.566681981086731 169.39016 277.05884000000003 117.92503999999997 170.40796 268.5069199999999 756.4410799999999 UP 1.0 0.0 0.0 GO:0002250 4 adaptive immune response 53 57 2 2 2 2 2 2 57 55 2433 0.85615 0.38289 0.38289 3.51 294228;316137 rt1-s3;adgre1 RT1-S3_9763;EMR1_8558 169.136 169.136 119.065 70.81108728158323 196.96387923378322 58.86788901175191 115.35305 115.35305 89.1701 37.02828299293666 129.90470606007838 30.78298804897547 331.4235 331.4235 178.281 216.57620047572172 416.53526121027426 180.04784591844052 219.207;119.065 141.536;89.1701 484.566;178.281 1 1 1 316137 EMR1_8558 119.065 119.065 89.1701 89.1701 178.281 178.281 119.065 89.1701 178.281 1 294228 RT1-S3_9763 219.207 219.207 141.536 141.536 484.566 484.566 219.207 141.536 484.566 0 Linear,2(1) 2.348228186344938 4.874089479446411 1.7851157188415527 3.0889737606048584 0.9219668630354462 2.4370447397232056 70.99683999999999 267.27516 64.034468 166.671632 31.264200000000017 631.5827999999999 CONFLICT 0.5 0.5 0.0 GO:0032355 5 response to estradiol 114 121 5 5 5 4 4 4 55 117 2371 0.85414 0.30692 0.36163 3.31 79212;25595;24494;24232 slc6a1;map2;il1b;c3 SLC6A1_32594;MAP2_32650;IL1B_8892;C3_8175 147.298 145.441 144.319 4.493240107836127 147.40387403517983 4.5353497534257174 94.1494 104.72 57.6936 24.40653944827086 95.07119943292203 23.790250915862607 221.5275 237.091 153.26 46.63444206806817 223.301294145445 45.56265830151915 145.445;145.437;153.991;144.319 104.722;104.718;109.464;57.6936 237.101;237.081;258.668;153.26 4 0 4 79212;25595;24494;24232 SLC6A1_32594;MAP2_32650;IL1B_8892;C3_8175 147.298 145.441 4.493240107836127 94.1494 104.72 24.40653944827086 221.5275 237.091 46.63444206806817 145.445;145.437;153.991;144.319 104.722;104.718;109.464;57.6936 237.101;237.081;258.668;153.26 0 0 Exp 5,1(0.25);Linear,3(0.75) 2.1428391032714633 8.724431037902832 1.7257766723632812 2.8712503910064697 0.48951131318415997 2.0637019872665405 142.89462469432064 151.70137530567936 70.2309913406946 118.0678086593054 175.82574677329325 267.22925322670676 UP 1.0 0.0 0.0 GO:1901564 4 organonitrogen compound metabolic process 832 911 22 20 18 16 15 15 44 896 1592 0.059223 0.96799 0.10032 1.65 29142;365377;29483;303872;362282;25247;497009;24494;24451;24450;84488;171142;297594;64564;29650 vnn1;trim72;slc1a3;pigz;pck1;nsg1;naaa;il1b;hmox1;hmgcs2;fgf13;ehhadh;cdca3;bbox1;adam10 VNN1_10157;TRIM72_33144;SLC1A3_32817;PIGZ_32744;PCK1_9439;NSG1_32675;NAAA_32484;IL1B_8892;HMOX1_8815;HMGCS2_8812;FGF13_32529;EHHADH_8534;CDCA3_8260;BBOX1_8133;ADAM10_7983 231.2748266666667 227.854 61.2776 102.11303608751749 204.2330744757263 98.2894394109845 144.6908666666667 148.568 39.7754 57.257788087394246 129.26168801705893 57.243029680455216 526.0097333333333 483.266 140.784 325.60884337092625 435.3639098313345 260.5269410003956 233.741;82.0928;303.435;355.097;227.854;216.472;151.002;153.991;61.2776;269.456;209.76;250.691;183.234;454.248;316.771 147.819;49.3056;189.179;212.48;148.568;166.237;107.821;109.464;39.7754;162.134;130.074;157.555;111.531;259.457;178.963 556.851;193.467;992.735;459.59;506.507;342.576;250.969;258.668;140.784;795.183;483.266;636.947;407.422;491.171;1374.01 12 3 12 29142;365377;29483;303872;362282;25247;497009;24494;24451;24450;171142;64564 VNN1_10157;TRIM72_33144;SLC1A3_32817;PIGZ_32744;PCK1_9439;NSG1_32675;NAAA_32484;IL1B_8892;HMOX1_8815;HMGCS2_8812;EHHADH_8534;BBOX1_8133 229.94645000000003 230.7975 111.14177288628413 145.81625 153.06150000000002 62.80949090830864 468.78733333333327 475.3805 254.05945941392736 233.741;82.0928;303.435;355.097;227.854;216.472;151.002;153.991;61.2776;269.456;250.691;454.248 147.819;49.3056;189.179;212.48;148.568;166.237;107.821;109.464;39.7754;162.134;157.555;259.457 556.851;193.467;992.735;459.59;506.507;342.576;250.969;258.668;140.784;795.183;636.947;491.171 3 84488;297594;29650 FGF13_32529;CDCA3_8260;ADAM10_7983 236.58833333333337 209.76 70.69548920782229 140.18933333333334 130.074 34.835450798480196 754.8993333333334 483.266 537.5049685996709 209.76;183.234;316.771 130.074;111.531;178.963 483.266;407.422;1374.01 0 Exp 2,6(0.4);Linear,5(0.34);Poly 2,3(0.2);Power,1(0.07) 1.997068156591007 30.82503867149353 1.5923793315887451 3.437419891357422 0.5515846834204051 1.892825961112976 179.59850047550935 282.951152857824 115.71442793212157 173.66730540121182 361.22892330688165 690.790543359785 UP 0.8 0.2 0.0 GO:0007346 6 regulation of mitotic cell cycle 146 155 3 3 3 2 2 2 57 153 2335 0.29231 0.88418 0.58039 1.29 360243;24494 top2a;il1b TOP2A_10059;IL1B_8892 178.7295 178.7295 153.991 34.98552221276678 172.03981317411404 33.68208640869992 108.953 108.953 108.442 0.7226631303695091 109.09118258859785 0.6957392790540705 415.4605 415.4605 258.668 221.7380799783835 373.0612954545455 213.47690980601493 203.468;153.991 108.442;109.464 572.253;258.668 1 1 1 24494 IL1B_8892 153.991 153.991 109.464 109.464 258.668 258.668 153.991 109.464 258.668 1 360243 TOP2A_10059 203.468 203.468 108.442 108.442 572.253 572.253 203.468 108.442 572.253 0 Exp 2,1(0.5);Linear,1(0.5) 2.444249633713008 4.952001094818115 2.0807507038116455 2.8712503910064697 0.5589676893413048 2.4760005474090576 130.24204000000003 227.21695999999997 107.95143999999999 109.95456000000001 108.14720000000005 722.7737999999999 CONFLICT 0.5 0.5 0.0 GO:0007584 4 response to nutrient 144 154 6 6 6 6 6 6 53 148 2340 0.93778 0.14284 0.16698 3.9 24494;24451;24450;24408;25279;245920 il1b;hmox1;hmgcs2;grin1;cyp24a1;cxcl10 IL1B_8892;HMOX1_8815;HMGCS2_8812;GRIN1_32381;CYP24A1_32574;CXCL10_8408 221.32276666666667 229.2835 61.2776 106.2439369854425 217.7911955668348 105.64045511434475 146.93856666666667 144.85649999999998 39.7754 73.24595338287752 143.60913794853673 69.70538038490348 676.4603333333333 405.7285 140.784 709.8704905737853 705.3867374795208 783.6225970667164 153.991;61.2776;269.456;310.025;189.111;344.076 109.464;39.7754;162.134;254.954;127.579;187.725 258.668;140.784;795.183;447.21;364.247;2052.67 5 1 5 24494;24451;24450;24408;25279 IL1B_8892;HMOX1_8815;HMGCS2_8812;GRIN1_32381;CYP24A1_32574 196.77212 189.111 97.92451579952794 138.78128 127.579 78.7854819461809 401.21840000000003 364.247 248.41342102692437 153.991;61.2776;269.456;310.025;189.111 109.464;39.7754;162.134;254.954;127.579 258.668;140.784;795.183;447.21;364.247 1 245920 CXCL10_8408 344.076 344.076 187.725 187.725 2052.67 2052.67 344.076 187.725 2052.67 0 Exp 2,1(0.17);Linear,4(0.67);Poly 2,1(0.17) 2.113108780425195 12.914015889167786 1.5923793315887451 2.8712503910064697 0.45751774855302546 2.0359808802604675 136.30991159961042 306.3356217337229 88.32959757283376 205.54753576049953 108.44564144744982 1244.475025219217 UP 0.8333333333333334 0.16666666666666666 0.0 GO:0032570 5 response to progesterone 36 40 3 3 3 3 3 3 56 37 2451 0.98725 0.063691 0.063691 7.5 78968;25595;24232 srebf1;map2;c3 SREBF1_32750;MAP2_32650;C3_8175 155.914 145.437 144.319 19.123084714553872 159.7731902605896 20.41293453003674 93.22253333333333 104.718 57.6936 31.401101714005733 89.58046817587282 35.135175124534754 246.37400000000002 237.081 153.26 98.09120881608095 250.81378529027066 113.65882905109036 1.0 145.437 177.986;145.437;144.319 117.256;104.718;57.6936 348.781;237.081;153.26 2 1 2 25595;24232 MAP2_32650;C3_8175 144.878 144.878 0.7905453813722293 81.20580000000001 81.20580000000001 33.25127212122867 195.1705 195.1705 59.27039750583753 145.437;144.319 104.718;57.6936 237.081;153.26 1 78968 SREBF1_32750 177.986 177.986 117.256 117.256 348.781 348.781 177.986 117.256 348.781 0 Exp 2,1(0.34);Exp 5,1(0.34);Linear,1(0.34) 1.7996880981500738 5.440392851829529 1.5889767408370972 2.1256394386291504 0.2788701323533968 1.7257766723632812 134.27419250894008 177.5538074910599 57.68884165956657 128.75622500710008 135.3733478024037 357.3746521975963 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0000070 6 mitotic sister chromatid segregation 13 13 1 1 1 1 1 1 58 12 2476 0.96507 0.26318 0.26318 7.69 500545 cdca8 CDCA8_33310 453.898 453.898 453.898 453.8980000000001 224.22 224.22 224.22 224.22 474.793 474.793 474.793 474.79299999999995 0.0 453.898 453.898 224.22 474.793 0 1 0 1 500545 CDCA8_33310 453.898 453.898 224.22 224.22 474.793 474.793 453.898 224.22 474.793 0 Power,1(1) 1.9873988628387451 1.9873988628387451 1.9873988628387451 1.9873988628387451 0.0 1.9873988628387451 453.898 453.898 224.22 224.22 474.793 474.793 DOWN 0.0 1.0 0.0 GO:0001764 5 neuron migration 31 35 4 4 4 2 2 2 57 33 2455 0.95426 0.19371 0.19371 5.71 84488;25311 fgf13;dcc FGF13_32529;DCC_32537 228.97899999999998 228.97899999999998 209.76 27.17977045524866 228.87369915324587 27.179362491849506 156.8665 156.8665 130.074 37.89031686988112 156.71970396812216 37.88974814313314 391.3375 391.3375 299.409 130.00653146861526 391.84117599203057 130.00458009428016 0.5 228.97899999999998 209.76;248.198 130.074;183.659 483.266;299.409 0 2 0 2 84488;25311 FGF13_32529;DCC_32537 228.97899999999998 228.97899999999998 27.17977045524866 156.8665 156.8665 37.89031686988112 391.3375 391.3375 130.00653146861526 209.76;248.198 130.074;183.659 483.266;299.409 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.7938553377089632 3.5978503227233887 1.6639630794525146 1.933887243270874 0.19086520664207046 1.7989251613616943 191.30975999999998 266.64824 104.35320000000003 209.3798 211.15763999999996 571.51736 DOWN 0.0 1.0 0.0 GO:0007568 3 aging 181 193 7 7 6 5 4 4 55 189 2299 0.53324 0.66552 1.0 2.07 360243;78968;362282;298566 top2a;srebf1;pck1;c1qa TOP2A_10059;SREBF1_32750;PCK1_9439;C1QA_8167 219.44074999999998 215.661 177.986 38.50023601118148 228.8374033638958 45.50478909853152 134.00475 132.912 108.442 25.27204280590172 139.17414281377134 26.834594627986988 553.6195 539.38 348.781 181.62476140567045 605.0424649341187 214.45489381874444 203.468;177.986;227.854;268.455 108.442;117.256;148.568;161.753 572.253;348.781;506.507;786.937 2 2 2 362282;298566 PCK1_9439;C1QA_8167 248.15449999999998 248.15449999999998 28.709242422955093 155.1605 155.1605 9.323202909944063 646.722 646.722 198.29395464814385 227.854;268.455 148.568;161.753 506.507;786.937 2 360243;78968 TOP2A_10059;SREBF1_32750 190.72699999999998 190.72699999999998 18.018494998195845 112.84899999999999 112.84899999999999 6.2324391693785035 460.51700000000005 460.51700000000005 158.0185666053199 203.468;177.986 108.442;117.256 572.253;348.781 0 Exp 2,3(0.75);Linear,1(0.25) 1.9488958315804485 7.849967837333679 1.5889767408370972 2.162810802459717 0.2560237822894477 2.0490901470184326 181.71051870904222 257.17098129095774 109.23814805021622 158.77135194978376 375.62723382244315 731.6117661775569 CONFLICT 0.5 0.5 0.0 GO:1903508 9 positive regulation of nucleic acid-templated transcription 309 333 12 12 10 9 8 8 51 325 2163 0.63629 0.5147 0.84587 2.4 360243;78968;291773;362282;24494;24408;304729;25311 top2a;srebf1;taf4b;pck1;il1b;grin1;gli2;dcc TOP2A_10059;SREBF1_32750;RGD1562997_32695;PCK1_9439;IL1B_8892;GRIN1_32381;GLI2_8713;DCC_32537 234.392625 238.026 153.991 53.683688536084105 232.493707730641 56.60356872528629 156.5165 156.156 108.442 48.84281874397854 159.28408102773193 51.347053605058875 519.1089999999999 476.8585 258.668 235.22718736939055 476.6868241594667 233.48564786538319 203.468;177.986;279.902;227.854;153.991;310.025;273.717;248.198 108.442;117.256;166.045;148.568;109.464;254.954;163.744;183.659 572.253;348.781;888.462;506.507;258.668;447.21;831.582;299.409 3 5 3 362282;24494;24408 PCK1_9439;IL1B_8892;GRIN1_32381 230.62333333333333 227.854 78.0538544489209 170.99533333333338 148.568 75.29325325242172 404.12833333333333 447.21 129.41431521409586 227.854;153.991;310.025 148.568;109.464;254.954 506.507;258.668;447.21 5 360243;78968;291773;304729;25311 TOP2A_10059;SREBF1_32750;RGD1562997_32695;GLI2_8713;DCC_32537 236.6542 248.198 44.498775906759526 147.8292 163.744 32.9959955100615 588.0974 572.253 269.4290351767976 203.468;177.986;279.902;273.717;248.198 108.442;117.256;166.045;163.744;183.659 572.253;348.781;888.462;831.582;299.409 0 Exp 2,4(0.5);Linear,3(0.38);Poly 2,1(0.13) 2.017145331528922 16.390992879867554 1.5889767408370972 2.8712503910064697 0.400600156942135 2.0073189735412598 197.19172680108787 271.5935231989121 122.67015342078997 190.36284657921 356.1048754778322 682.1131245221679 DOWN 0.375 0.625 0.0 GO:0002274 4 myeloid leukocyte activation 50 53 3 3 2 3 2 2 57 51 2437 0.87731 0.3491 0.3491 3.77 298566;29650 c1qa;adam10 C1QA_8167;ADAM10_7983 292.613 292.613 268.455 34.16457123980878 274.4634645426516 22.547874697294425 170.358 170.358 161.753 12.169307704220154 163.89319527235352 8.031478672499327 1080.4735 1080.4735 786.937 415.1232993515297 859.9440226104831 273.97235785588504 268.455;316.771 161.753;178.963 786.937;1374.01 1 1 1 298566 C1QA_8167 268.455 268.455 161.753 161.753 786.937 786.937 268.455 161.753 786.937 1 29650 ADAM10_7983 316.771 316.771 178.963 178.963 1374.01 1374.01 316.771 178.963 1374.01 0 Linear,2(1) 1.8208839985844951 3.6609162092208862 1.6434866189956665 2.0174295902252197 0.26441761073346315 1.8304581046104431 245.26331999999996 339.96268000000003 153.4922 187.2238 505.14196000000004 1655.8050400000002 CONFLICT 0.5 0.5 0.0 GO:0007389 3 pattern specification process 49 53 4 4 4 4 4 4 55 49 2439 0.99312 0.032708 0.032708 7.55 313506;304729;24232;298566 stil;gli2;c3;c1qa STIL_33274;GLI2_8713;C3_8175;C1QA_8167 249.53175 271.086 144.319 72.73164450854026 254.22292364136666 66.6979296313167 140.10815 162.74849999999998 57.6936 55.372176539817055 144.63896047695485 50.9946334957955 764.41725 809.2595 153.26 465.6412266981059 780.7324760376061 428.0574467829514 1.5 271.086 311.636;273.717;144.319;268.455 177.242;163.744;57.6936;161.753 1285.89;831.582;153.26;786.937 2 2 2 24232;298566 C3_8175;C1QA_8167 206.387 206.387 87.7774073893732 109.7233 109.7233 73.5811073862034 470.0985 470.0985 448.07730378194793 144.319;268.455 57.6936;161.753 153.26;786.937 2 313506;304729 STIL_33274;GLI2_8713 292.67650000000003 292.67650000000003 26.812782035812145 170.493 170.493 9.544527332455957 1058.736 1058.736 321.2442675472976 311.636;273.717 177.242;163.744 1285.89;831.582 0 Exp 5,1(0.25);Linear,3(0.75) 1.880609102507328 7.5757458209991455 1.6343638896942139 2.1981756687164307 0.2604276500722107 1.8716031312942505 178.2547383816306 320.80876161836943 85.84341699097928 194.3728830090207 308.0888478358563 1220.7456521641436 CONFLICT 0.5 0.5 0.0 GO:0010883 4 regulation of lipid storage 20 22 3 3 3 3 3 3 56 19 2469 0.99861 0.013298 0.013298 13.64 78968;58827;24232 srebf1;mest;c3 SREBF1_32750;MEST_9219;C3_8175 198.17766666666662 177.986 144.319 66.30200315475662 185.52308219537818 58.924542061638526 124.5972 117.256 57.6936 70.8599860197559 112.04718270308126 64.70428377702892 348.443 348.781 153.26 195.0142196841041 315.71660653011213 181.21900325381284 0.5 161.15249999999997 1.5 225.107 177.986;272.228;144.319 117.256;198.842;57.6936 348.781;543.288;153.26 2 1 2 58827;24232 MEST_9219;C3_8175 208.2735 208.2735 90.44532127479015 128.26780000000002 128.26780000000002 99.80699079363124 348.274 348.274 275.79144365262675 272.228;144.319 198.842;57.6936 543.288;153.26 1 78968 SREBF1_32750 177.986 177.986 117.256 117.256 348.781 348.781 177.986 117.256 348.781 0 Exp 2,2(0.67);Exp 5,1(0.34) 1.815022020004313 5.495190501213074 1.5889767408370972 2.1804370880126953 0.30963840661464725 1.7257766723632812 123.14988710301495 273.20544623031833 44.41157727357282 204.7828227264272 127.76363602837228 569.1223639716277 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0071103 7 DNA conformation change 30 32 3 3 2 2 2 2 57 30 2458 0.96361 0.16853 0.16853 6.25 360243;316273 top2a;mcm3 TOP2A_10059;MCM3_9207 216.2805 216.2805 203.468 18.11961126790528 223.22387512092874 15.228243377360439 120.97999999999999 120.97999999999999 108.442 17.731409645033985 127.77461754272814 14.901987548515404 593.571 593.571 572.253 30.1482047226699 605.1236923573041 25.337419888279463 0.5 216.2805 203.468;229.093 108.442;133.518 572.253;614.889 0 2 0 2 360243;316273 TOP2A_10059;MCM3_9207 216.2805 216.2805 18.11961126790528 120.97999999999999 120.97999999999999 17.731409645033985 593.571 593.571 30.1482047226699 203.468;229.093 108.442;133.518 572.253;614.889 0 Exp 2,2(1) 1.9629769337348963 3.932620048522949 1.8518693447113037 2.0807507038116455 0.161843561107045 1.9663100242614746 191.168 241.39299999999997 96.40551999999998 145.55448 551.78772 635.35428 DOWN 0.0 1.0 0.0 GO:0009749 8 response to glucose 89 93 5 5 5 3 3 3 56 90 2398 0.83338 0.36613 0.47469 3.23 78968;362282;24494 srebf1;pck1;il1b SREBF1_32750;PCK1_9439;IL1B_8892 186.61033333333333 177.986 153.991 37.67917244756488 173.64547034014853 29.203769692022615 125.096 117.256 109.464 20.697340505485357 117.8299844136793 15.289345434112445 371.31866666666673 348.781 258.668 125.4472091930837 328.6028478958467 99.04435031117433 177.986;227.854;153.991 117.256;148.568;109.464 348.781;506.507;258.668 2 1 2 362282;24494 PCK1_9439;IL1B_8892 190.9225 190.9225 52.22902817878198 129.01600000000002 129.01600000000002 27.650703571518648 382.5875 382.5875 175.24863754249296 227.854;153.991 148.568;109.464 506.507;258.668 1 78968 SREBF1_32750 177.986 177.986 117.256 117.256 348.781 348.781 177.986 117.256 348.781 0 Exp 2,2(0.67);Linear,1(0.34) 2.144876935639448 6.623037934303284 1.5889767408370972 2.8712503910064697 0.6423132536409956 2.162810802459717 143.97233583666326 229.24833083000345 101.67475437979155 148.51724562020846 229.36178587310675 513.2755474602266 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0003002 4 regionalization 36 40 3 3 3 3 3 3 56 37 2451 0.98725 0.063691 0.063691 7.5 304729;24232;298566 gli2;c3;c1qa GLI2_8713;C3_8175;C1QA_8167 228.83033333333333 268.455 144.319 73.2362359582559 237.61210394985807 67.88414537379612 127.73020000000001 161.753 57.6936 60.661643770343 135.20621021759698 56.36622554530176 590.593 786.937 153.26 379.39874627230915 634.5796990302745 350.7007382080939 1.0 268.455 273.717;144.319;268.455 163.744;57.6936;161.753 831.582;153.26;786.937 2 1 2 24232;298566 C3_8175;C1QA_8167 206.387 206.387 87.7774073893732 109.7233 109.7233 73.5811073862034 470.0985 470.0985 448.07730378194793 144.319;268.455 57.6936;161.753 153.26;786.937 1 304729 GLI2_8713 273.717 273.717 163.744 163.744 831.582 831.582 273.717 163.744 831.582 0 Exp 5,1(0.34);Linear,2(0.67) 1.97067553794848 5.941381931304932 1.7257766723632812 2.1981756687164307 0.23835945584445792 2.0174295902252197 145.95573066526268 311.7049360014039 59.085087933826216 196.37531206617376 161.26290215057247 1019.9230978494274 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0006396 7 RNA processing 67 78 2 2 2 2 2 2 57 76 2412 0.73036 0.54566 0.70186 2.56 681410;316098 loc681410;exosc7 LOC681410_33126;EXOSC7_8580 261.288 261.288 111.985 211.1463275029902 270.55508275862064 210.73920843613737 190.77300000000002 190.77300000000002 54.886 192.17323835019275 199.20736551724139 191.80270200037108 434.4355 434.4355 373.527 86.13762676380146 438.21602758620685 85.971541610232 410.591;111.985 326.66;54.886 495.344;373.527 2 0 2 681410;316098 LOC681410_33126;EXOSC7_8580 261.288 261.288 211.1463275029902 190.77300000000002 190.77300000000002 192.17323835019275 434.4355 434.4355 86.13762676380146 410.591;111.985 326.66;54.886 495.344;373.527 0 0 Poly 2,2(1) 1.826360557323673 3.657788634300232 1.7326574325561523 1.9251312017440796 0.13609950739331772 1.828894317150116 -31.345879999999966 553.92188 -75.56551999999994 457.11152 315.05484 553.81616 UP 1.0 0.0 0.0 GO:0007155 3 cell adhesion 145 150 4 4 4 4 4 4 55 146 2342 0.73466 0.46209 0.7761 2.67 29142;288280;24494;29182 vnn1;ncam2;il1b;cdh22 VNN1_10157;NCAM2_32618;IL1B_8892;CDH22_32502 252.30675000000002 270.4015 153.991 74.98551440722834 257.032103915236 80.3614647458809 183.95000000000002 182.255 109.464 68.28923246993868 196.42174712448298 76.21874502153939 497.19175000000007 486.172 258.668 212.1482959525795 442.03278395376515 187.3584892643405 233.741;314.433;153.991;307.062 147.819;261.826;109.464;216.691 556.851;415.493;258.668;757.755 4 0 4 29142;288280;24494;29182 VNN1_10157;NCAM2_32618;IL1B_8892;CDH22_32502 252.30675000000002 270.4015 74.98551440722834 183.95000000000002 182.255 68.28923246993868 497.19175000000007 486.172 212.1482959525795 233.741;314.433;153.991;307.062 147.819;261.826;109.464;216.691 556.851;415.493;258.668;757.755 0 0 Exp 2,2(0.5);Linear,2(0.5) 2.0101483288407476 8.23430335521698 1.7034999132156372 2.8712503910064697 0.5511149229297716 1.8297765254974365 178.82094588091616 325.7925541190839 117.02655217946004 250.87344782053992 289.28641996647195 705.0970800335281 UP 1.0 0.0 0.0 GO:0051384 7 response to glucocorticoid 119 133 6 6 6 5 5 5 54 128 2360 0.91561 0.19215 0.23284 3.76 362282;24494;24450;25315;24232 pck1;il1b;hmgcs2;ephx1;c3 PCK1_9439;IL1B_8892;HMGCS2_8812;EPHX1_8567;C3_8175 161.62588 153.991 12.5094 98.24337478106092 159.6360474840861 66.64481678941125 96.22832000000001 109.464 3.282 65.92064743092259 93.53082428008487 49.78937725388012 355.00292 258.668 61.3966 297.02579130899056 290.5911697787208 230.06640778168486 227.854;153.991;269.456;12.5094;144.319 148.568;109.464;162.134;3.282;57.6936 506.507;258.668;795.183;61.3966;153.26 5 0 5 362282;24494;24450;25315;24232 PCK1_9439;IL1B_8892;HMGCS2_8812;EPHX1_8567;C3_8175 161.62588 153.991 98.24337478106092 96.22832000000001 109.464 65.92064743092259 355.00292 258.668 297.02579130899056 227.854;153.991;269.456;12.5094;144.319 148.568;109.464;162.134;3.282;57.6936 506.507;258.668;795.183;61.3966;153.26 0 0 Exp 2,1(0.2);Exp 5,1(0.2);Hill,1(0.2);Linear,2(0.4) 2.121468472565 10.769334554672241 1.7257766723632812 2.8712503910064697 0.43621761567143824 2.1014184951782227 75.51176517501925 247.73999482498078 38.44632487967484 154.0103151203252 94.64833470847293 615.3575052915271 UP 1.0 0.0 0.0 GO:0050808 6 synapse organization 39 44 3 3 3 3 3 3 56 41 2447 0.98232 0.080066 0.080066 6.82 84488;24232;298566 fgf13;c3;c1qa FGF13_32529;C3_8175;C1QA_8167 207.51133333333328 209.76 144.319 62.09854265869171 218.67703562958468 60.22988039623599 116.50686666666667 130.074 57.6936 53.33985388293948 125.87865220892394 50.20291291878059 474.4876666666667 483.266 153.26 316.92969162628685 531.4824682587833 307.7646608873802 1.5 239.1075 209.76;144.319;268.455 130.074;57.6936;161.753 483.266;153.26;786.937 2 1 2 24232;298566 C3_8175;C1QA_8167 206.387 206.387 87.7774073893732 109.7233 109.7233 73.5811073862034 470.0985 470.0985 448.07730378194793 144.319;268.455 57.6936;161.753 153.26;786.937 1 84488 FGF13_32529 209.76 209.76 130.074 130.074 483.266 483.266 209.76 130.074 483.266 0 Exp 2,1(0.34);Exp 5,1(0.34);Linear,1(0.34) 1.7960105723180044 5.407169342041016 1.6639630794525146 2.0174295902252197 0.1887771697900956 1.7257766723632812 137.24021710558642 277.78244956108017 56.147139830879865 176.86659350245347 115.84795882840785 833.1273745049255 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0010193 5 response to ozone 6 6 2 2 2 2 2 2 57 4 2484 0.99978 0.0074544 0.0074544 33.33 24494;25086 il1b;cyp2e1 IL1B_8892;CYP2E1_8421 255.68349999999998 255.68349999999998 153.991 143.81491269162592 242.2695367806887 142.5582698197545 150.6165 150.6165 109.464 58.19842362555879 145.18819288410938 57.68989058934974 1434.674 1434.674 258.668 1663.1236346321339 1279.55045372383 1648.5913971792434 0.0 153.991 0.0 153.991 153.991;357.376 109.464;191.769 258.668;2610.68 2 0 2 24494;25086 IL1B_8892;CYP2E1_8421 255.68349999999998 255.68349999999998 143.81491269162592 150.6165 150.6165 58.19842362555879 1434.674 1434.674 1663.1236346321339 153.991;357.376 109.464;191.769 258.668;2610.68 0 0 Linear,2(1) 2.2790013758537433 4.68016517162323 1.8089147806167603 2.8712503910064697 0.7511847140025137 2.340082585811615 56.36620000000002 455.0007999999999 69.9576 231.2754 -870.2977599999999 3739.64576 UP 1.0 0.0 0.0 GO:0016192 4 vesicle-mediated transport 163 173 4 4 3 3 2 2 57 171 2317 0.2234 0.9189 0.43182 1.16 365377;25247 trim72;nsg1 TRIM72_33144;NSG1_32675 149.2824 149.2824 82.0928 95.02044357042334 111.86861665653494 78.92592937797134 107.7713 107.7713 49.3056 82.68298587363665 75.21532358662614 68.6781839634952 268.0215 268.0215 193.467 105.435985035945 226.50665379939213 87.57729175065717 82.0928;216.472 49.3056;166.237 193.467;342.576 2 0 2 365377;25247 TRIM72_33144;NSG1_32675 149.2824 149.2824 95.02044357042334 107.7713 107.7713 82.68298587363665 268.0215 268.0215 105.435985035945 82.0928;216.472 49.3056;166.237 193.467;342.576 0 0 Exp 2,1(0.5);Poly 2,1(0.5) 2.3931428063027473 5.103533625602722 1.6661137342453003 3.437419891357422 1.2525025952514652 2.551766812801361 17.590783999999985 280.974016 -6.821472 222.364072 121.89468 414.14832 UP 1.0 0.0 0.0 GO:0002933 6 lipid hydroxylation 3 3 2 2 2 2 2 2 57 1 2487 0.99999 0.0015595 0.0015595 66.67 50549;25086 cyp4a1;cyp2e1 CYP4A1_33111;CYP2E1_8421 366.4905 366.4905 357.376 12.8898495142487 366.671801084991 12.88729918691829 194.4305 194.4305 191.769 3.7639293962582445 194.48344122965645 3.7631846822053427 3288.7 3288.7 2610.68 958.8650795602043 3302.1868354430376 958.675362852025 0.0 357.376 0.0 357.376 375.605;357.376 197.092;191.769 3966.72;2610.68 2 0 2 50549;25086 CYP4A1_33111;CYP2E1_8421 366.4905 366.4905 12.8898495142487 194.4305 194.4305 3.7639293962582445 3288.7 3288.7 958.8650795602043 375.605;357.376 197.092;191.769 3966.72;2610.68 0 0 Linear,2(1) 1.691128232992363 3.3899260759353638 1.5810112953186035 1.8089147806167603 0.16115209991037527 1.6949630379676819 348.62607999999994 384.35492000000005 189.21396 199.64704 1959.7808 4617.619199999999 UP 1.0 0.0 0.0 GO:0010524 10 positive regulation of calcium ion transport into cytosol 20 21 2 2 2 2 2 2 57 19 2469 0.98833 0.083624 0.083624 9.52 24408;245920 grin1;cxcl10 GRIN1_32381;CXCL10_8408 327.0505 327.0505 310.025 24.077693006183818 330.63017289337336 23.53948139728109 221.3395 221.3395 187.725 47.53808179239053 214.27192991546227 46.47545725111569 1249.94 1249.94 447.21 1135.2316529237544 1418.7168830106355 1109.855681303848 0.5 327.0505 310.025;344.076 254.954;187.725 447.21;2052.67 1 1 1 24408 GRIN1_32381 310.025 310.025 254.954 254.954 447.21 447.21 310.025 254.954 447.21 1 245920 CXCL10_8408 344.076 344.076 187.725 187.725 2052.67 2052.67 344.076 187.725 2052.67 0 Exp 2,1(0.5);Linear,1(0.5) 2.1761070949658263 4.387260556221008 1.9169143438339233 2.470346212387085 0.3913354271786826 2.193630278110504 293.68051999999994 360.42048000000005 155.45507999999998 287.22392 -323.4107999999999 2823.2907999999998 CONFLICT 0.5 0.5 0.0 GO:0009267 5 cellular response to starvation 53 55 3 3 2 3 2 2 57 53 2435 0.86688 0.36608 0.36608 3.64 78968;362282 srebf1;pck1 SREBF1_32750;PCK1_9439 202.92000000000002 202.92000000000002 177.986 35.2620009642106 189.95934026845637 30.123932522934062 132.912 132.912 117.256 22.140927532513246 124.77403221476509 18.91474643374748 427.644 427.644 348.781 111.52912416942948 386.6511184563758 95.27808175808747 177.986;227.854 117.256;148.568 348.781;506.507 1 1 1 362282 PCK1_9439 227.854 227.854 148.568 148.568 506.507 506.507 227.854 148.568 506.507 1 78968 SREBF1_32750 177.986 177.986 117.256 117.256 348.781 348.781 177.986 117.256 348.781 0 Exp 2,2(1) 1.8538220140940467 3.751787543296814 1.5889767408370972 2.162810802459717 0.40576195624917355 1.875893771648407 154.04936 251.79064000000002 102.22623999999999 163.59776000000002 273.07252000000005 582.21548 CONFLICT 0.5 0.5 0.0 GO:0006875 8 cellular metal ion homeostasis 132 139 7 7 7 5 5 5 54 134 2354 0.90058 0.21711 0.25218 3.6 24567;24494;24451;24408;245920 mt1;il1b;hmox1;grin1;cxcl10 MT1A_9255;IL1B_8892;HMOX1_8815;GRIN1_32381;CXCL10_8408 252.42451999999997 310.025 61.2776 139.31636144635704 257.4703138214597 137.1812261803149 160.66268 187.725 39.7754 85.77882865726254 160.83469195066024 82.30702985057309 1901.9644 447.21 140.784 2743.6934653694098 1908.511733138294 2633.3491785034216 392.753;153.991;61.2776;310.025;344.076 211.395;109.464;39.7754;254.954;187.725 6610.49;258.668;140.784;447.21;2052.67 4 1 4 24567;24494;24451;24408 MT1A_9255;IL1B_8892;HMOX1_8815;GRIN1_32381 229.51164999999997 232.00799999999998 149.59523391903232 153.89710000000002 160.42950000000002 97.49627057571651 1864.288 352.93899999999996 3166.6504440972535 392.753;153.991;61.2776;310.025 211.395;109.464;39.7754;254.954 6610.49;258.668;140.784;447.21 1 245920 CXCL10_8408 344.076 344.076 187.725 187.725 2052.67 2052.67 344.076 187.725 2052.67 0 Exp 2,2(0.4);Linear,2(0.4);Poly 2,1(0.2) 2.105903532748318 10.76388704776764 1.5923793315887451 2.8712503910064697 0.5109367663360728 1.9169143438339233 130.30834500778184 374.5406949922182 85.47422157208517 235.8511384279148 -502.9889584112823 4306.917758411282 UP 0.8 0.2 0.0 GO:0009059 5 macromolecule biosynthetic process 162 182 5 5 4 4 3 3 56 179 2309 0.38156 0.80586 0.79667 1.65 78968;291773;24494 srebf1;taf4b;il1b SREBF1_32750;RGD1562997_32695;IL1B_8892 203.95966666666664 177.986 153.991 66.85333574574524 185.27204528795815 54.68551957817544 130.92166666666665 117.256 109.464 30.666190248110926 122.3389277486911 24.873826258503932 498.637 348.781 258.668 340.5917441174991 403.3131198080279 276.46403731220107 177.986;279.902;153.991 117.256;166.045;109.464 348.781;888.462;258.668 1 2 1 24494 IL1B_8892 153.991 153.991 109.464 109.464 258.668 258.668 153.991 109.464 258.668 2 78968;291773 SREBF1_32750;RGD1562997_32695 228.944 228.944 72.06549471140809 141.6505 141.6505 34.499032747310494 618.6215 618.6215 381.61209477753727 177.986;279.902 117.256;166.045 348.781;888.462 0 Exp 2,1(0.34);Linear,2(0.67) 1.9551836688904223 6.098454117774963 1.5889767408370972 2.8712503910064697 0.7265211648698959 1.6382269859313965 128.30799554416706 279.61133778916627 96.21960560492312 165.6237277284102 113.22115910599553 884.0528408940045 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0070291 7 N-acylethanolamine metabolic process 2 2 1 1 1 1 1 1 58 1 2487 0.99947 0.045801 0.045801 50.0 497009 naaa NAAA_32484 151.002 151.002 151.002 151.002 107.821 107.821 107.821 107.82099999999998 250.969 250.969 250.969 250.969 0.0 151.002 0.0 151.002 151.002 107.821 250.969 1 0 1 497009 NAAA_32484 151.002 151.002 107.821 107.821 250.969 250.969 151.002 107.821 250.969 0 0 Linear,1(1) 2.1505277156829834 2.1505277156829834 2.1505277156829834 2.1505277156829834 0.0 2.1505277156829834 151.002 151.002 107.821 107.821 250.969 250.969 UP 1.0 0.0 0.0 GO:0009987 2 cellular process 2111 2325 82 79 70 61 55 55 4 2270 218 0.77054 0.40473 0.81492 2.37 29142;286989;246118;365377;360243;366669;313506;78968;79212;29483;84487;294228;291773;303872;362282;25247;338475;288280;497009;24567;316273;25595;25211;361680;681410;311024;24503;24494;24451;24450;24416;24408;304729;84488;80841;316098;25315;316137;171142;29740;25311;50549;25086;25279;245920;502902;363198;29182;500545;297594;24232;298566;64564;29650;170924 vnn1;ugt2b7;tubb3;trim72;top2a;syne2;stil;srebf1;slc6a1;slc1a3;slc17a6;rt1-s3;taf4b;pigz;pck1;nsg1;nrep;ncam2;naaa;mt1;mcm3;map2;lyz2;lsp1;loc681410;kif5c;ina;il1b;hmox1;hmgcs2;grm3;grin1;gli2;fgf13;fabp7;exosc7;ephx1;adgre1;ehhadh;eci1;dcc;cyp4a1;cyp2e1;cyp24a1;cxcl10;clec7a;cenpq;cdh22;cdca8;cdca3;c3;c1qa;bbox1;adam10;abcc4 VNN1_10157;UGT2B7_33032;TUBB3_32820;TRIM72_33144;TOP2A_10059;SYNE2_9977;STIL_33274;SREBF1_32750;SLC6A1_32594;SLC1A3_32817;SLC17A6_32912;RT1-S3_9763;RGD1562997_32695;PIGZ_32744;PCK1_9439;NSG1_32675;NREP_9364;NCAM2_32618;NAAA_32484;MT1A_9255;MCM3_9207;MAP2_32650;LYZ2_32611;LSP1_32853;LOC681410_33126;KIF5C_8965;INA_32322;IL1B_8892;HMOX1_8815;HMGCS2_8812;GRM3_33234;GRIN1_32381;GLI2_8713;FGF13_32529;FABP7_8592;EXOSC7_8580;EPHX1_8567;EMR1_8558;EHHADH_8534;ECI1_8520;DCC_32537;CYP4A1_33111;CYP2E1_8421;CYP24A1_32574;CXCL10_8408;CLEC7A_32927;CENPQ_8290;CDH22_32502;CDCA8_33310;CDCA3_8260;C3_8175;C1QA_8167;BBOX1_8133;ADAM10_7983;ABCC4_32768 243.38836309090908 244.652 4.13867 104.07810096621417 245.08333368062878 101.81507665526291 157.41634327272732 161.753 1.39768 71.91644606911976 159.91478354032196 72.05852292212367 723.7538945454546 464.331 16.5686 1029.953880140256 688.1231348615242 1002.9898223254801 233.741;4.13867;282.273;82.0928;203.468;276.757;311.636;177.986;145.445;303.435;369.631;219.207;279.902;355.097;227.854;216.472;222.026;314.433;151.002;392.753;229.093;145.437;214.715;231.535;410.591;256.817;305.642;153.991;61.2776;269.456;286.986;310.025;273.717;209.76;227.998;111.985;12.5094;119.065;250.691;195.758;248.198;375.605;357.376;189.111;344.076;412.985;39.9715;307.062;453.898;183.234;144.319;268.455;454.248;316.771;244.652 147.819;1.39768;238.208;49.3056;108.442;164.88;177.242;117.256;104.722;189.179;163.45;141.536;166.045;212.48;148.568;166.237;142.777;261.826;107.821;211.395;133.518;104.718;139.536;141.502;326.66;208.309;249.176;109.464;39.7754;162.134;241.819;254.954;163.744;130.074;194.92;54.886;3.282;89.1701;157.555;130.778;183.659;197.092;191.769;127.579;187.725;338.673;12.1775;216.691;224.22;111.531;57.6936;161.753;259.457;178.963;152.355 556.851;16.5686;354.06;193.467;572.253;858.911;1285.89;348.781;237.101;992.735;452.105;484.566;888.462;459.59;506.507;342.576;497.741;415.493;250.969;6610.49;614.889;237.081;464.331;580.905;495.344;372.239;459.059;258.668;140.784;795.183;363.86;447.21;831.582;483.266;274.42;373.527;61.3966;178.281;636.947;388.001;299.409;3966.72;2610.68;364.247;2052.67;488.745;177.403;757.755;474.793;407.422;153.26;786.937;491.171;1374.01;619.152 38 17 38 29142;286989;246118;365377;79212;29483;84487;303872;362282;25247;288280;497009;24567;25595;25211;681410;311024;24503;24494;24451;24450;24416;24408;80841;316098;25315;316137;171142;29740;50549;25086;25279;502902;29182;24232;298566;64564;170924 VNN1_10157;UGT2B7_33032;TUBB3_32820;TRIM72_33144;SLC6A1_32594;SLC1A3_32817;SLC17A6_32912;PIGZ_32744;PCK1_9439;NSG1_32675;NCAM2_32618;NAAA_32484;MT1A_9255;MAP2_32650;LYZ2_32611;LOC681410_33126;KIF5C_8965;INA_32322;IL1B_8892;HMOX1_8815;HMGCS2_8812;GRM3_33234;GRIN1_32381;FABP7_8592;EXOSC7_8580;EPHX1_8567;EMR1_8558;EHHADH_8534;ECI1_8520;CYP4A1_33111;CYP2E1_8421;CYP24A1_32574;CLEC7A_32927;CDH22_32502;C3_8175;C1QA_8167;BBOX1_8133;ABCC4_32768 241.18748605263156 247.67149999999998 111.92273833108698 162.43703631578947 161.94349999999997 80.87053804754896 725.6187157894738 431.3515 1204.9325372886597 233.741;4.13867;282.273;82.0928;145.445;303.435;369.631;355.097;227.854;216.472;314.433;151.002;392.753;145.437;214.715;410.591;256.817;305.642;153.991;61.2776;269.456;286.986;310.025;227.998;111.985;12.5094;119.065;250.691;195.758;375.605;357.376;189.111;412.985;307.062;144.319;268.455;454.248;244.652 147.819;1.39768;238.208;49.3056;104.722;189.179;163.45;212.48;148.568;166.237;261.826;107.821;211.395;104.718;139.536;326.66;208.309;249.176;109.464;39.7754;162.134;241.819;254.954;194.92;54.886;3.282;89.1701;157.555;130.778;197.092;191.769;127.579;338.673;216.691;57.6936;161.753;259.457;152.355 556.851;16.5686;354.06;193.467;237.101;992.735;452.105;459.59;506.507;342.576;415.493;250.969;6610.49;237.081;464.331;495.344;372.239;459.059;258.668;140.784;795.183;363.86;447.21;274.42;373.527;61.3966;178.281;636.947;388.001;3966.72;2610.68;364.247;488.745;757.755;153.26;786.937;491.171;619.152 17 360243;366669;313506;78968;294228;291773;338475;316273;361680;304729;84488;25311;245920;363198;500545;297594;29650 TOP2A_10059;SYNE2_9977;STIL_33274;SREBF1_32750;RT1-S3_9763;RGD1562997_32695;NREP_9364;MCM3_9207;LSP1_32853;GLI2_8713;FGF13_32529;DCC_32537;CXCL10_8408;CENPQ_8290;CDCA8_33310;CDCA3_8260;ADAM10_7983 248.30797058823532 231.535 86.91165538574033 146.1936176470588 142.777 46.237169912152915 719.5854705882352 572.253 471.9727672316113 203.468;276.757;311.636;177.986;219.207;279.902;222.026;229.093;231.535;273.717;209.76;248.198;344.076;39.9715;453.898;183.234;316.771 108.442;164.88;177.242;117.256;141.536;166.045;142.777;133.518;141.502;163.744;130.074;183.659;187.725;12.1775;224.22;111.531;178.963 572.253;858.911;1285.89;348.781;484.566;888.462;497.741;614.889;580.905;831.582;483.266;299.409;2052.67;177.403;474.793;407.422;1374.01 0 Exp 2,19(0.35);Exp 4,1(0.02);Exp 5,1(0.02);Hill,3(0.06);Linear,22(0.4);Poly 2,7(0.13);Power,2(0.04) 2.0016099867863146 114.16031086444855 1.5261523723602295 5.283818244934082 0.6679159632208569 1.8991773128509521 215.8819420790211 270.894784102797 138.40980851765812 176.4228780277964 451.5511469265095 995.9566421643992 UP 0.6909090909090909 0.3090909090909091 0.0 GO:0010556 6 regulation of macromolecule biosynthetic process 567 609 19 19 16 13 11 11 48 598 1890 0.21309 0.86908 0.43957 1.81 360243;311715;78968;291773;362282;24494;24451;24408;304729;25311;502902 top2a;tcfl5;srebf1;taf4b;pck1;il1b;hmox1;grin1;gli2;dcc;clec7a TOP2A_10059;TCFL5_9994;SREBF1_32750;RGD1562997_32695;PCK1_9439;IL1B_8892;HMOX1_8815;GRIN1_32381;GLI2_8713;DCC_32537;CLEC7A_32927 238.21132727272732 248.198 61.2776 91.22035519300591 243.8399682572614 103.33613447738749 169.02303636363635 163.744 39.7754 81.85037204786883 177.91559098172507 92.3809488068107 465.56981818181816 447.21 140.784 230.7229681981479 434.34440315176124 219.3556990518555 203.468;270.921;177.986;279.902;227.854;153.991;61.2776;310.025;273.717;248.198;412.985 108.442;228.673;117.256;166.045;148.568;109.464;39.7754;254.954;163.744;183.659;338.673 572.253;338.867;348.781;888.462;506.507;258.668;140.784;447.21;831.582;299.409;488.745 6 5 6 311715;362282;24494;24451;24408;502902 TCFL5_9994;PCK1_9439;IL1B_8892;HMOX1_8815;GRIN1_32381;CLEC7A_32927 239.50893333333337 249.3875 122.69371774539495 186.68456666666668 188.6205 108.18726334465929 363.4635 393.0385 144.46011058385648 270.921;227.854;153.991;61.2776;310.025;412.985 228.673;148.568;109.464;39.7754;254.954;338.673 338.867;506.507;258.668;140.784;447.21;488.745 5 360243;78968;291773;304729;25311 TOP2A_10059;SREBF1_32750;RGD1562997_32695;GLI2_8713;DCC_32537 236.6542 248.198 44.498775906759526 147.8292 163.744 32.9959955100615 588.0974 572.253 269.4290351767976 203.468;177.986;279.902;273.717;248.198 108.442;117.256;166.045;163.744;183.659 572.253;348.781;888.462;831.582;299.409 0 Exp 2,5(0.46);Linear,3(0.28);Poly 2,3(0.28) 1.9654364617388207 21.927884697914124 1.5889767408370972 2.8712503910064697 0.36636824988333905 1.933887243270874 184.30354225640258 292.11911228905194 120.65255753216381 217.39351519510888 329.22125714368167 601.9183792199548 CONFLICT 0.5454545454545454 0.45454545454545453 0.0 GO:0008355 8 olfactory learning 1 1 1 1 1 1 1 1 58 0 2488 1.0 0.023165 0.023165 100.0 24408 grin1 GRIN1_32381 310.025 310.025 310.025 310.025 254.954 254.954 254.954 254.954 447.21 447.21 447.21 447.21 0.0 310.025 0.0 310.025 310.025 254.954 447.21 1 0 1 24408 GRIN1_32381 310.025 310.025 254.954 254.954 447.21 447.21 310.025 254.954 447.21 0 0 Exp 2,1(1) 1.9169143438339233 1.9169143438339233 1.9169143438339233 1.9169143438339233 0.0 1.9169143438339233 310.025 310.025 254.954 254.954 447.21 447.21 UP 1.0 0.0 0.0 GO:1903506 8 regulation of nucleic acid-templated transcription 474 508 15 15 13 11 10 10 49 498 1990 0.34803 0.76821 0.62495 1.97 360243;311715;78968;291773;362282;24494;24451;24408;304729;25311 top2a;tcfl5;srebf1;taf4b;pck1;il1b;hmox1;grin1;gli2;dcc TOP2A_10059;TCFL5_9994;SREBF1_32750;RGD1562997_32695;PCK1_9439;IL1B_8892;HMOX1_8815;GRIN1_32381;GLI2_8713;DCC_32537 220.73396000000002 238.026 61.2776 74.24517318313534 214.71777369932474 78.91631011410553 152.05803999999998 156.156 39.7754 62.659230822799714 150.2375179468605 65.64767115748789 463.2523 397.9955 140.784 243.06836774503046 424.97809336920807 237.29189134737635 203.468;270.921;177.986;279.902;227.854;153.991;61.2776;310.025;273.717;248.198 108.442;228.673;117.256;166.045;148.568;109.464;39.7754;254.954;163.744;183.659 572.253;338.867;348.781;888.462;506.507;258.668;140.784;447.21;831.582;299.409 5 5 5 311715;362282;24494;24451;24408 TCFL5_9994;PCK1_9439;IL1B_8892;HMOX1_8815;GRIN1_32381 204.81372000000002 227.854 98.93938425062082 156.28688000000002 148.568 87.75226365953185 338.4072 338.867 146.2096719259708 270.921;227.854;153.991;61.2776;310.025 228.673;148.568;109.464;39.7754;254.954 338.867;506.507;258.668;140.784;447.21 5 360243;78968;291773;304729;25311 TOP2A_10059;SREBF1_32750;RGD1562997_32695;GLI2_8713;DCC_32537 236.6542 248.198 44.498775906759526 147.8292 163.744 32.9959955100615 588.0974 572.253 269.4290351767976 203.468;177.986;279.902;273.717;248.198 108.442;117.256;166.045;163.744;183.659 572.253;348.781;888.462;831.582;299.409 0 Exp 2,5(0.5);Linear,3(0.3);Poly 2,2(0.2) 1.952477239468569 19.82802975177765 1.5889767408370972 2.8712503910064697 0.3843900423145911 1.9254007935523987 174.7163249036571 266.7515950963429 113.22144637648239 190.89463362351756 312.5969648341145 613.9076351658856 CONFLICT 0.5 0.5 0.0 GO:0010646 5 regulation of cell communication 678 722 29 27 23 18 15 15 44 707 1781 0.36705 0.73822 0.66402 2.08 29142;365377;78968;79212;29483;25247;338475;24494;24451;24416;24408;304729;25311;24232;29650 vnn1;trim72;srebf1;slc6a1;slc1a3;nsg1;nrep;il1b;hmox1;grm3;grin1;gli2;dcc;c3;adam10 VNN1_10157;TRIM72_33144;SREBF1_32750;SLC6A1_32594;SLC1A3_32817;NSG1_32675;NREP_9364;IL1B_8892;HMOX1_8815;GRM3_33234;GRIN1_32381;GLI2_8713;DCC_32537;C3_8175;ADAM10_7983 211.76549333333335 222.026 61.2776 81.681513889072 198.91465109695272 84.82838953225168 143.15784 147.819 39.7754 64.55054370386047 139.43447951970475 71.42440687892163 469.20233333333334 348.781 140.784 346.9694278151621 383.12928765820044 268.2478989385638 233.741;82.0928;177.986;145.445;303.435;216.472;222.026;153.991;61.2776;286.986;310.025;273.717;248.198;144.319;316.771 147.819;49.3056;117.256;104.722;189.179;166.237;142.777;109.464;39.7754;241.819;254.954;163.744;183.659;57.6936;178.963 556.851;193.467;348.781;237.101;992.735;342.576;497.741;258.668;140.784;363.86;447.21;831.582;299.409;153.26;1374.01 10 5 10 29142;365377;79212;29483;25247;24494;24451;24416;24408;24232 VNN1_10157;TRIM72_33144;SLC6A1_32594;SLC1A3_32817;NSG1_32675;IL1B_8892;HMOX1_8815;GRM3_33234;GRIN1_32381;C3_8175 193.77844 185.2315 89.89687286815813 136.09686 128.6415 77.32977687719008 368.6512 300.622 256.0777234568529 233.741;82.0928;145.445;303.435;216.472;153.991;61.2776;286.986;310.025;144.319 147.819;49.3056;104.722;189.179;166.237;109.464;39.7754;241.819;254.954;57.6936 556.851;193.467;237.101;992.735;342.576;258.668;140.784;363.86;447.21;153.26 5 78968;338475;304729;25311;29650 SREBF1_32750;NREP_9364;GLI2_8713;DCC_32537;ADAM10_7983 247.73960000000002 248.198 52.36201763969748 157.2798 163.744 27.47746809114694 670.3046 497.741 444.95248545243567 177.986;222.026;273.717;248.198;316.771 117.256;142.777;163.744;183.659;178.963 348.781;497.741;831.582;299.409;1374.01 0 Exp 2,5(0.34);Exp 5,1(0.07);Linear,6(0.4);Poly 2,3(0.2) 2.0090053181867877 31.38467836380005 1.5347857475280762 3.667783737182617 0.6816223526617079 1.9169143438339233 170.42894398324293 253.10204268342378 110.49075771485171 175.8249222851482 293.61157609869144 644.7930905679752 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0002703 6 regulation of leukocyte mediated immunity 69 79 5 5 5 4 4 4 55 75 2413 0.96578 0.10822 0.10822 5.06 294228;24494;24451;24232 rt1-s3;il1b;hmox1;c3 RT1-S3_9763;IL1B_8892;HMOX1_8815;C3_8175 144.69865 149.155 61.2776 64.79983977724537 158.5349696684939 67.40134617796413 87.11725 83.5788 39.7754 46.78952706133428 97.7604435917515 48.56986783803747 259.3195 205.964 140.784 159.20185563721716 302.16493918037065 174.7851223255194 2.5 186.599 219.207;153.991;61.2776;144.319 141.536;109.464;39.7754;57.6936 484.566;258.668;140.784;153.26 3 1 3 24494;24451;24232 IL1B_8892;HMOX1_8815;C3_8175 119.86253333333333 144.319 50.96599558777727 68.97766666666666 57.6936 36.18871181588722 184.23733333333334 153.26 64.75998571134289 153.991;61.2776;144.319 109.464;39.7754;57.6936 258.668;140.784;153.26 1 294228 RT1-S3_9763 219.207 219.207 141.536 141.536 484.566 484.566 219.207 141.536 484.566 0 Exp 5,1(0.25);Linear,2(0.5);Poly 2,1(0.25) 1.9372788714483977 7.974522113800049 1.5923793315887451 2.8712503910064697 0.590605130405191 1.755446195602417 81.19480701829957 208.2024929817004 41.2635134798924 132.9709865201076 103.3016814755272 415.33731852447283 UP 0.75 0.25 0.0 GO:0010970 6 transport along microtubule 17 20 2 2 2 2 2 2 57 18 2470 0.98983 0.076772 0.076772 10.0 366669;311024 syne2;kif5c SYNE2_9977;KIF5C_8965 266.78700000000003 266.78700000000003 256.817 14.09970921685928 264.7547458033573 13.803683775008206 186.59449999999998 186.59449999999998 164.88 30.708940400150816 191.0207170263789 30.064201738459293 615.5749999999999 615.5749999999999 372.239 344.1290714136195 565.9741366906474 336.90403160237474 0.0 256.817 1.0 276.757 276.757;256.817 164.88;208.309 858.911;372.239 1 1 1 311024 KIF5C_8965 256.817 256.817 208.309 208.309 372.239 372.239 256.817 208.309 372.239 1 366669 SYNE2_9977 276.757 276.757 164.88 164.88 858.911 858.911 276.757 164.88 858.911 0 Exp 2,1(0.5);Linear,1(0.5) 2.027382660823596 4.09917676448822 1.748702883720398 2.3504738807678223 0.4255163527336236 2.04958838224411 247.24580000000003 286.32820000000004 144.03408 229.15491999999998 138.63643999999994 1092.5135599999999 CONFLICT 0.5 0.5 0.0 GO:1901615 4 organic hydroxy compound metabolic process 134 145 9 9 8 7 7 7 52 138 2350 0.98301 0.047559 0.077773 4.83 78968;362282;497009;24450;25315;25086;25279 srebf1;pck1;naaa;hmgcs2;ephx1;cyp2e1;cyp24a1 SREBF1_32750;PCK1_9439;NAAA_32484;HMGCS2_8812;EPHX1_8567;CYP2E1_8421;CYP24A1_32574 197.8992 189.111 12.5094 106.84335006048187 198.41522070930748 80.12199494636863 122.62985714285715 127.579 3.282 59.902937105032876 127.23444240738834 38.75495291765594 705.3948 364.247 61.3966 870.1074343906503 640.407689271123 834.972721623507 177.986;227.854;151.002;269.456;12.5094;357.376;189.111 117.256;148.568;107.821;162.134;3.282;191.769;127.579 348.781;506.507;250.969;795.183;61.3966;2610.68;364.247 6 1 6 362282;497009;24450;25315;25086;25279 PCK1_9439;NAAA_32484;HMGCS2_8812;EPHX1_8567;CYP2E1_8421;CYP24A1_32574 201.21806666666666 208.48250000000002 116.64508898614923 123.52550000000001 138.0735 65.5690168379853 764.8304333333332 435.377 937.4596220512576 227.854;151.002;269.456;12.5094;357.376;189.111 148.568;107.821;162.134;3.282;191.769;127.579 506.507;250.969;795.183;61.3966;2610.68;364.247 1 78968 SREBF1_32750 177.986 177.986 117.256 117.256 348.781 348.781 177.986 117.256 348.781 0 Exp 2,2(0.29);Hill,1(0.15);Linear,4(0.58) 1.9709081971655615 13.875774145126343 1.5889767408370972 2.162810802459717 0.22180700389458466 2.1014184951782227 118.74853861970522 277.04986138029483 78.25314031582423 167.00657396989007 60.810192114289066 1349.9794078857108 UP 0.8571428571428571 0.14285714285714285 0.0 GO:1901740 7 negative regulation of myoblast fusion 3 3 1 1 1 1 1 1 58 2 2486 0.99844 0.067922 0.067922 33.33 245920 cxcl10 CXCL10_8408 344.076 344.076 344.076 344.076 187.725 187.725 187.725 187.725 2052.67 2052.67 2052.67 2052.67 0.0 344.076 0.0 344.076 344.076 187.725 2052.67 0 1 0 1 245920 CXCL10_8408 344.076 344.076 187.725 187.725 2052.67 2052.67 344.076 187.725 2052.67 0 Linear,1(1) 2.470346212387085 2.470346212387085 2.470346212387085 2.470346212387085 0.0 2.470346212387085 344.076 344.076 187.725 187.725 2052.67 2052.67 DOWN 0.0 1.0 0.0 GO:0051186 4 cofactor metabolic process 111 126 4 3 3 3 3 3 56 123 2365 0.66631 0.56613 0.76667 2.38 29142;24451;24450 vnn1;hmox1;hmgcs2 VNN1_10157;HMOX1_8815;HMGCS2_8812 188.1582 233.741 61.2776 111.32342654859313 144.70800898245614 113.71775526203909 116.57613333333332 147.819 39.7754 66.89539809772668 90.74898212865496 69.17513453548679 497.606 556.851 140.784 331.19781146468955 366.4777529824561 319.358639854567 233.741;61.2776;269.456 147.819;39.7754;162.134 556.851;140.784;795.183 3 0 3 29142;24451;24450 VNN1_10157;HMOX1_8815;HMGCS2_8812 188.1582 233.741 111.32342654859313 116.57613333333332 147.819 66.89539809772668 497.606 556.851 331.19781146468955 233.741;61.2776;269.456 147.819;39.7754;162.134 556.851;140.784;795.183 0 0 Linear,2(0.67);Poly 2,1(0.34) 1.803198366126326 5.430148720741272 1.5923793315887451 1.929691195487976 0.18881745456522783 1.9080781936645508 62.18388384151413 314.1325161584858 40.87686417876475 192.27540248790189 122.82039461585936 872.3916053841406 UP 1.0 0.0 0.0 GO:0050708 6 regulation of protein secretion 128 139 5 5 5 3 3 3 56 136 2352 0.59633 0.63423 1.0 2.16 78968;294228;24494 srebf1;rt1-s3;il1b SREBF1_32750;RT1-S3_9763;IL1B_8892 183.72799999999998 177.986 153.991 32.98499032893609 191.54195594785443 34.54395562187167 122.752 117.256 109.464 16.727456710450678 126.94478305268875 17.685747578146053 364.00500000000005 348.781 258.668 113.71589261400511 390.4602058120586 118.69454091224665 177.986;219.207;153.991 117.256;141.536;109.464 348.781;484.566;258.668 1 2 1 24494 IL1B_8892 153.991 153.991 109.464 109.464 258.668 258.668 153.991 109.464 258.668 2 78968;294228 SREBF1_32750;RT1-S3_9763 198.5965 198.5965 29.147648627290792 129.39600000000002 129.39600000000002 17.168552647209175 416.6735 416.6735 96.01449428341554 177.986;219.207 117.256;141.536 348.781;484.566 0 Exp 2,1(0.34);Linear,2(0.67) 2.0119552978394277 6.24534285068512 1.5889767408370972 2.8712503910064697 0.6906982866020579 1.7851157188415527 146.40196963056837 221.05403036943164 103.82310079611248 141.68089920388752 235.32335362480424 492.6866463751958 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0051592 6 response to calcium ion 51 56 3 3 2 3 2 2 57 54 2434 0.86155 0.37451 0.37451 3.57 79212;24408 slc6a1;grin1 SLC6A1_32594;GRIN1_32381 227.73499999999999 227.73499999999999 145.445 116.37563404768197 200.30499999999998 109.72 179.838 179.838 104.722 106.23006595121745 154.79933333333332 100.15466666666674 342.15549999999996 342.15549999999996 237.101 148.56949868832447 307.13733333333334 140.0726666666666 145.445;310.025 104.722;254.954 237.101;447.21 2 0 2 79212;24408 SLC6A1_32594;GRIN1_32381 227.73499999999999 227.73499999999999 116.37563404768197 179.838 179.838 106.23006595121745 342.15549999999996 342.15549999999996 148.56949868832447 145.445;310.025 104.722;254.954 237.101;447.21 0 0 Exp 2,1(0.5);Linear,1(0.5) 1.9588800759240728 3.918678879737854 1.9169143438339233 2.0017645359039307 0.0599981461976832 1.959339439868927 66.44660000000002 389.0233999999999 32.61064000000002 327.06536000000006 136.24868 548.0623199999999 UP 1.0 0.0 0.0 GO:1901360 4 organic cyclic compound metabolic process 507 567 21 20 16 15 13 13 46 554 1934 0.55701 0.56879 1.0 2.29 286989;360243;78968;291773;362282;316273;681410;24451;24450;316098;25315;25086;25279 ugt2b7;top2a;srebf1;taf4b;pck1;mcm3;loc681410;hmox1;hmgcs2;exosc7;ephx1;cyp2e1;cyp24a1 UGT2B7_33032;TOP2A_10059;SREBF1_32750;RGD1562997_32695;PCK1_9439;MCM3_9207;LOC681410_33126;HMOX1_8815;HMGCS2_8812;EXOSC7_8580;EPHX1_8567;CYP2E1_8421;CYP24A1_32574 194.98059 203.468 4.13867 123.40283075824058 195.5308611378519 107.65627138158624 121.63939076923079 127.579 1.39768 87.2173857278072 121.72057594875571 73.87177907936976 599.1247846153846 495.344 16.5686 658.0376046356138 590.055077799607 649.2895375748092 4.13867;203.468;177.986;279.902;227.854;229.093;410.591;61.2776;269.456;111.985;12.5094;357.376;189.111 1.39768;108.442;117.256;166.045;148.568;133.518;326.66;39.7754;162.134;54.886;3.282;191.769;127.579 16.5686;572.253;348.781;888.462;506.507;614.889;495.344;140.784;795.183;373.527;61.3966;2610.68;364.247 9 4 9 286989;362282;681410;24451;24450;316098;25315;25086;25279 UGT2B7_33032;PCK1_9439;LOC681410_33126;HMOX1_8815;HMGCS2_8812;EXOSC7_8580;EPHX1_8567;CYP2E1_8421;CYP24A1_32574 182.69985222222223 189.111 146.9037101200529 117.33900888888888 127.579 105.3622822653473 596.0263555555555 373.527 794.4114825622473 4.13867;227.854;410.591;61.2776;269.456;111.985;12.5094;357.376;189.111 1.39768;148.568;326.66;39.7754;162.134;54.886;3.282;191.769;127.579 16.5686;506.507;495.344;140.784;795.183;373.527;61.3966;2610.68;364.247 4 360243;78968;291773;316273 TOP2A_10059;SREBF1_32750;RGD1562997_32695;MCM3_9207 222.61224999999996 216.2805 43.520570127814366 131.31525 125.387 25.376207483585958 606.09625 593.571 221.48305629607395 203.468;177.986;279.902;229.093 108.442;117.256;166.045;133.518 572.253;348.781;888.462;614.889 0 Exp 2,4(0.31);Hill,2(0.16);Linear,4(0.31);Poly 2,3(0.24) 1.9630930030877787 26.1164208650589 1.5889767408370972 3.570159435272217 0.5116695870263543 1.9080781936645508 127.89804705238208 262.0631329476179 74.22747981131394 169.0513017271476 241.41146796872908 956.8381012620403 UP 0.6923076923076923 0.3076923076923077 0.0 GO:0006766 4 vitamin metabolic process 19 23 2 2 2 2 2 2 57 21 2467 0.98496 0.097858 0.097858 8.7 29142;25279 vnn1;cyp24a1 VNN1_10157;CYP24A1_32574 211.426 211.426 189.111 31.558175644355806 198.65999490984385 25.883907704908147 137.69899999999998 137.69899999999998 127.579 14.311841251215824 131.9095323095505 11.738523234312137 460.549 460.549 364.247 136.19159448365397 405.4563796911397 111.70387989236299 0.5 211.426 233.741;189.111 147.819;127.579 556.851;364.247 2 0 2 29142;25279 VNN1_10157;CYP24A1_32574 211.426 211.426 31.558175644355806 137.69899999999998 137.69899999999998 14.311841251215824 460.549 460.549 136.19159448365397 233.741;189.111 147.819;127.579 556.851;364.247 0 0 Linear,2(1) 2.0392586951733307 4.084738612174988 1.929691195487976 2.1550474166870117 0.1593509121924137 2.042369306087494 167.68859999999995 255.16340000000002 117.8638 157.53419999999997 271.79708 649.3009199999999 UP 1.0 0.0 0.0 GO:0071222 6 cellular response to lipopolysaccharide 81 86 5 5 3 4 3 3 56 83 2405 0.8639 0.32099 0.44967 3.49 24494;24450;245920 il1b;hmgcs2;cxcl10 IL1B_8892;HMGCS2_8812;CXCL10_8408 255.841 269.456 153.991 95.77109676201906 263.7177127774353 108.90213254150697 153.10766666666666 162.134 109.464 39.90365961078422 155.18276672318126 44.921175929747484 1035.507 795.183 258.668 920.8297957456632 1235.7618574291 1044.1706672637144 153.991;269.456;344.076 109.464;162.134;187.725 258.668;795.183;2052.67 2 1 2 24494;24450 IL1B_8892;HMGCS2_8812 211.7235 211.7235 81.64608448970486 135.79899999999998 135.79899999999998 37.243314165095626 526.9255 526.9255 379.37339470830045 153.991;269.456 109.464;162.134 258.668;795.183 1 245920 CXCL10_8408 344.076 344.076 187.725 187.725 2052.67 2052.67 344.076 187.725 2052.67 0 Linear,3(1) 2.3830968143742033 7.2496747970581055 1.9080781936645508 2.8712503910064697 0.4838336778696284 2.470346212387085 147.4658017475708 364.2161982524292 107.95242497550919 198.26290835782413 -6.510007685110168 2077.5240076851105 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0044255 4 cellular lipid metabolic process 218 243 15 14 13 11 11 11 48 232 2256 0.99177 0.021175 0.023684 4.53 303872;362282;497009;24451;24450;25315;171142;29740;50549;25086;24232 pigz;pck1;naaa;hmox1;hmgcs2;ephx1;ehhadh;eci1;cyp4a1;cyp2e1;c3 PIGZ_32744;PCK1_9439;NAAA_32484;HMOX1_8815;HMGCS2_8812;EPHX1_8567;EHHADH_8534;ECI1_8520;CYP4A1_33111;CYP2E1_8421;C3_8175 218.26772727272729 227.854 12.5094 120.03080969705312 227.48491879233686 114.01437564162154 128.0861818181818 148.568 3.282 68.65472154539434 134.34209854512443 63.97779606506934 906.3670545454545 459.59 61.3966 1236.1392446135314 894.2589281035406 1237.1505813421352 355.097;227.854;151.002;61.2776;269.456;12.5094;250.691;195.758;375.605;357.376;144.319 212.48;148.568;107.821;39.7754;162.134;3.282;157.555;130.778;197.092;191.769;57.6936 459.59;506.507;250.969;140.784;795.183;61.3966;636.947;388.001;3966.72;2610.68;153.26 11 0 11 303872;362282;497009;24451;24450;25315;171142;29740;50549;25086;24232 PIGZ_32744;PCK1_9439;NAAA_32484;HMOX1_8815;HMGCS2_8812;EPHX1_8567;EHHADH_8534;ECI1_8520;CYP4A1_33111;CYP2E1_8421;C3_8175 218.26772727272729 227.854 120.03080969705312 128.0861818181818 148.568 68.65472154539434 906.3670545454545 459.59 1236.1392446135314 355.097;227.854;151.002;61.2776;269.456;12.5094;250.691;195.758;375.605;357.376;144.319 212.48;148.568;107.821;39.7754;162.134;3.282;157.555;130.778;197.092;191.769;57.6936 459.59;506.507;250.969;140.784;795.183;61.3966;636.947;388.001;3966.72;2610.68;153.26 0 0 Exp 2,2(0.19);Exp 5,1(0.1);Hill,1(0.1);Linear,5(0.46);Poly 2,2(0.19) 1.805205066757198 20.009570837020874 1.5261523723602295 2.162810802459717 0.23746676673766054 1.8089147806167603 147.3340516605956 289.20140288485896 87.51383410484475 168.65852953151887 175.85544331707138 1636.8786657738378 UP 1.0 0.0 0.0 GO:0051240 5 positive regulation of multicellular organismal process 484 516 14 14 12 10 9 9 50 507 1981 0.21402 0.87353 0.41319 1.74 29142;294228;24494;24451;24408;304729;25311;502902;24232 vnn1;rt1-s3;il1b;hmox1;grin1;gli2;dcc;clec7a;c3 VNN1_10157;RT1-S3_9763;IL1B_8892;HMOX1_8815;GRIN1_32381;GLI2_8713;DCC_32537;CLEC7A_32927;C3_8175 228.60673333333338 233.741 61.2776 102.3649826898338 235.3379306605769 104.18333898133515 159.702 147.819 39.7754 93.1913400651584 166.3547493318109 95.4775622064484 406.7861111111111 447.21 140.784 219.62283306582924 408.8990533494037 208.508483273274 233.741;219.207;153.991;61.2776;310.025;273.717;248.198;412.985;144.319 147.819;141.536;109.464;39.7754;254.954;163.744;183.659;338.673;57.6936 556.851;484.566;258.668;140.784;447.21;831.582;299.409;488.745;153.26 6 3 6 29142;24494;24451;24408;502902;24232 VNN1_10157;IL1B_8892;HMOX1_8815;GRIN1_32381;CLEC7A_32927;C3_8175 219.38976666666667 193.866 127.13134446424559 158.06316666666666 128.6415 117.0816920683617 340.91966666666667 352.93899999999996 179.8955680862279 233.741;153.991;61.2776;310.025;412.985;144.319 147.819;109.464;39.7754;254.954;338.673;57.6936 556.851;258.668;140.784;447.21;488.745;153.26 3 294228;304729;25311 RT1-S3_9763;GLI2_8713;DCC_32537 247.04066666666665 248.198 27.27342278360646 162.97966666666665 163.744 21.071899210401874 538.5189999999999 484.566 270.1577689776849 219.207;273.717;248.198 141.536;163.744;183.659 484.566;831.582;299.409 0 Exp 2,1(0.12);Exp 5,1(0.12);Linear,4(0.45);Poly 2,3(0.34) 1.978761937376152 18.053045511245728 1.5923793315887451 2.8712503910064697 0.3727859557248328 1.929691195487976 161.72827797597517 295.4851886906915 98.81699115742987 220.58700884257019 263.29919350810263 550.2730287141196 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0045596 6 negative regulation of cell differentiation 184 195 8 8 8 6 6 6 53 189 2299 0.83903 0.29536 0.45283 3.08 365377;25595;24494;304729;84488;245920 trim72;map2;il1b;gli2;fgf13;cxcl10 TRIM72_33144;MAP2_32650;IL1B_8892;GLI2_8713;FGF13_32529;CXCL10_8408 201.5123 181.8755 82.0928 95.15217498207805 205.98324059263058 104.57862178610974 124.17176666666667 119.769 49.3056 48.66111759019381 123.61891683930345 55.198717784912176 676.1223333333334 370.967 193.467 715.0141726513306 757.3830298560113 774.7013453535084 82.0928;145.437;153.991;273.717;209.76;344.076 49.3056;104.718;109.464;163.744;130.074;187.725 193.467;237.081;258.668;831.582;483.266;2052.67 3 3 3 365377;25595;24494 TRIM72_33144;MAP2_32650;IL1B_8892 127.17360000000001 145.437 39.27469446704841 87.8292 104.718 33.44670307698507 229.73866666666666 237.081 33.21483093940634 82.0928;145.437;153.991 49.3056;104.718;109.464 193.467;237.081;258.668 3 304729;84488;245920 GLI2_8713;FGF13_32529;CXCL10_8408 275.851 273.717 67.18342378146563 160.51433333333333 163.744 28.960878963410885 1122.506 831.582 824.157029416118 273.717;209.76;344.076 163.744;130.074;187.725 831.582;483.266;2052.67 0 Exp 2,1(0.17);Linear,4(0.67);Poly 2,1(0.17) 2.1242462944008587 12.99548852443695 1.6639630794525146 2.8712503910064697 0.46788808154566935 2.1619075536727905 125.37470297011063 277.6498970298894 85.23476325288172 163.10877008045162 103.99183859434868 1248.2528280723182 CONFLICT 0.5 0.5 0.0 GO:0071495 4 cellular response to endogenous stimulus 313 332 12 12 10 6 5 5 54 327 2161 0.19901 0.90046 0.43133 1.51 78968;362282;24450;24408;25315 srebf1;pck1;hmgcs2;grin1;ephx1 SREBF1_32750;PCK1_9439;HMGCS2_8812;GRIN1_32381;EPHX1_8567 199.56608 227.854 12.5094 115.4793073763954 225.05679642941408 94.61032506947447 137.2388 148.568 3.282 90.75892053787331 163.3528316162013 84.72044260057163 431.81552 447.21 61.3966 265.4979475091135 424.84491147463626 188.99527902638295 177.986;227.854;269.456;310.025;12.5094 117.256;148.568;162.134;254.954;3.282 348.781;506.507;795.183;447.21;61.3966 4 1 4 362282;24450;24408;25315 PCK1_9439;HMGCS2_8812;GRIN1_32381;EPHX1_8567 204.9611 248.65500000000003 132.61442469620974 142.23450000000003 155.351 104.00254205066332 452.57415 476.8585 301.84887285785373 227.854;269.456;310.025;12.5094 148.568;162.134;254.954;3.282 506.507;795.183;447.21;61.3966 1 78968 SREBF1_32750 177.986 177.986 117.256 117.256 348.781 348.781 177.986 117.256 348.781 0 Exp 2,3(0.6);Hill,1(0.2);Linear,1(0.2) 1.9247285978927953 9.67819857597351 1.5889767408370972 2.162810802459717 0.22381622013055208 1.9169143438339233 98.34400413502054 300.78815586497944 57.68509857222294 216.7925014277771 199.0963082613169 664.5347317386831 UP 0.8 0.2 0.0 GO:0006952 4 defense response 257 279 16 16 15 9 9 9 50 270 2218 0.89571 0.19082 0.28894 3.23 29142;294228;25211;361680;681410;24494;245920;24232;298566 vnn1;rt1-s3;lyz2;lsp1;loc681410;il1b;cxcl10;c3;c1qa VNN1_10157;RT1-S3_9763;LYZ2_32611;LSP1_32853;LOC681410_33126;IL1B_8892;CXCL10_8408;C3_8175;C1QA_8167 246.73666666666668 231.535 144.319 85.1977546681836 243.58236462262053 77.1109961014899 157.0765111111111 141.536 57.6936 73.09336262822438 150.95063451657273 58.95331720738069 648.1702222222223 495.344 153.26 557.3718260048173 717.623808736744 619.8694046877113 233.741;219.207;214.715;231.535;410.591;153.991;344.076;144.319;268.455 147.819;141.536;139.536;141.502;326.66;109.464;187.725;57.6936;161.753 556.851;484.566;464.331;580.905;495.344;258.668;2052.67;153.26;786.937 6 3 6 29142;25211;681410;24494;24232;298566 VNN1_10157;LYZ2_32611;LOC681410_33126;IL1B_8892;C3_8175;C1QA_8167 237.6353333333333 224.228 97.06527140366256 157.15426666666667 143.6775 90.90399139062411 452.5651666666667 479.8375 224.42291122380232 233.741;214.715;410.591;153.991;144.319;268.455 147.819;139.536;326.66;109.464;57.6936;161.753 556.851;464.331;495.344;258.668;153.26;786.937 3 294228;361680;245920 RT1-S3_9763;LSP1_32853;CXCL10_8408 264.9393333333333 231.535 68.81100133215135 156.92100000000002 141.536 26.677051954816736 1039.3803333333333 580.905 878.855654906045 219.207;231.535;344.076 141.536;141.502;187.725 484.566;580.905;2052.67 0 Exp 2,1(0.12);Exp 5,1(0.12);Linear,6(0.67);Poly 2,1(0.12) 1.945201749386756 17.8261376619339 1.5622447729110718 2.8712503910064697 0.4240712492295804 1.7851157188415527 191.07413361678675 302.39919971654666 109.32218086067115 204.83084136155105 284.02062923240817 1012.3198152120361 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0045765 6 regulation of angiogenesis 105 108 4 4 4 4 4 4 55 104 2384 0.89773 0.23904 0.31431 3.7 24494;24451;245920;24232 il1b;hmox1;cxcl10;c3 IL1B_8892;HMOX1_8815;CXCL10_8408;C3_8175 175.91590000000002 149.155 61.2776 119.58096892694365 192.00364125742433 127.22607929421812 98.6645 83.5788 39.7754 66.31978740949037 107.79488422425032 69.64812418209245 651.3455 205.964 140.784 935.7115267536606 786.1835355642474 1007.8539747251644 153.991;61.2776;344.076;144.319 109.464;39.7754;187.725;57.6936 258.668;140.784;2052.67;153.26 3 1 3 24494;24451;24232 IL1B_8892;HMOX1_8815;C3_8175 119.86253333333333 144.319 50.96599558777727 68.97766666666666 57.6936 36.18871181588722 184.23733333333334 153.26 64.75998571134289 153.991;61.2776;144.319 109.464;39.7754;57.6936 258.668;140.784;153.26 1 245920 CXCL10_8408 344.076 344.076 187.725 187.725 2052.67 2052.67 344.076 187.725 2052.67 0 Exp 5,1(0.25);Linear,2(0.5);Poly 2,1(0.25) 2.101188446183538 8.659752607345581 1.5923793315887451 2.8712503910064697 0.6090532188972142 2.098061442375183 58.726550451595216 293.1052495484048 33.67110833869941 163.65789166130057 -265.6517962185875 1568.3427962185874 UP 0.75 0.25 0.0 GO:0009653 3 anatomical structure morphogenesis 282 299 10 10 9 6 5 5 54 294 2194 0.2916 0.84019 0.54197 1.67 313506;29483;25595;304729;25311 stil;slc1a3;map2;gli2;dcc STIL_33274;SLC1A3_32817;MAP2_32650;GLI2_8713;DCC_32537 256.4846 273.717 145.437 66.97613343049893 274.5256295646239 43.306075510286796 163.70839999999998 177.242 104.718 34.31400877630016 174.5909243820389 20.355686578786507 729.3394000000001 831.582 237.081 451.867746948485 785.2349586563308 435.7114255116164 311.636;303.435;145.437;273.717;248.198 177.242;189.179;104.718;163.744;183.659 1285.89;992.735;237.081;831.582;299.409 2 3 2 29483;25595 SLC1A3_32817;MAP2_32650 224.436 224.436 111.72145721391212 146.9485 146.9485 59.72294584579704 614.908 614.908 534.3280676307393 303.435;145.437 189.179;104.718 992.735;237.081 3 313506;304729;25311 STIL_33274;GLI2_8713;DCC_32537 277.8503333333333 273.717 31.92034295450729 174.88166666666666 177.242 10.165145662179794 805.6270000000001 831.582 493.75240491464933 311.636;273.717;248.198 177.242;163.744;183.659 1285.89;831.582;299.409 0 Exp 2,1(0.2);Linear,3(0.6);Poly 2,1(0.2) 1.8999199592245464 9.568338751792908 1.6343638896942139 2.1981756687164307 0.25527080040292427 1.933887243270874 197.7774306094888 315.1917693905112 133.63084516790212 193.7859548320979 333.2598563855377 1125.4189436144623 DOWN 0.4 0.6 0.0 GO:0010647 6 positive regulation of cell communication 426 450 13 12 9 7 5 5 54 445 2043 0.036568 0.98643 0.081567 1.11 29483;24494;24408;25311;24232 slc1a3;il1b;grin1;dcc;c3 SLC1A3_32817;IL1B_8892;GRIN1_32381;DCC_32537;C3_8175 231.99359999999996 248.198 144.319 79.41441413748521 229.19891421025727 76.92986446588958 158.98991999999998 183.659 57.6936 76.5552250126143 158.4606296302607 74.57547449592728 430.25640000000004 299.409 153.26 331.64748857981715 402.6098034588516 306.82933301756844 303.435;153.991;310.025;248.198;144.319 189.179;109.464;254.954;183.659;57.6936 992.735;258.668;447.21;299.409;153.26 4 1 4 29483;24494;24408;24232 SLC1A3_32817;IL1B_8892;GRIN1_32381;C3_8175 227.9425 228.71300000000002 91.101351009009 152.82265 149.32150000000001 86.95229635048939 462.96825 352.93899999999996 373.52328089725535 303.435;153.991;310.025;144.319 189.179;109.464;254.954;57.6936 992.735;258.668;447.21;153.26 1 25311 DCC_32537 248.198 248.198 183.659 183.659 299.409 299.409 248.198 183.659 299.409 0 Exp 2,2(0.4);Exp 5,1(0.2);Linear,1(0.2);Poly 2,1(0.2) 1.9846632508279989 10.124101161956787 1.6762725114822388 2.8712503910064697 0.48663874364207943 1.9169143438339233 162.38379686534307 301.6034031346569 91.88630663288892 226.0935333671111 139.55455901962983 720.9582409803702 UP 0.8 0.2 0.0 GO:0009410 4 response to xenobiotic stimulus 123 132 6 6 6 5 5 5 54 127 2361 0.91799 0.1881 0.22981 3.79 79212;362282;24494;24408;25311 slc6a1;pck1;il1b;grin1;dcc SLC6A1_32594;PCK1_9439;IL1B_8892;GRIN1_32381;DCC_32537 217.1026 227.854 145.445 68.62028602607255 204.13123350393698 71.3714324298896 160.27339999999998 148.568 104.722 61.87865517123011 152.42446999999999 62.914183608932774 349.779 299.409 237.101 119.9907794895091 307.10691933070865 98.38898947265933 145.445;227.854;153.991;310.025;248.198 104.722;148.568;109.464;254.954;183.659 237.101;506.507;258.668;447.21;299.409 4 1 4 79212;362282;24494;24408 SLC6A1_32594;PCK1_9439;IL1B_8892;GRIN1_32381 209.32875 190.9225 76.65141820986307 154.42700000000002 129.01600000000002 69.83853760400959 362.3715 352.93899999999996 134.68448008215336 145.445;227.854;153.991;310.025 104.722;148.568;109.464;254.954 237.101;506.507;258.668;447.21 1 25311 DCC_32537 248.198 248.198 183.659 183.659 299.409 299.409 248.198 183.659 299.409 0 Exp 2,2(0.4);Linear,2(0.4);Poly 2,1(0.2) 2.151331264941157 10.886627316474915 1.9169143438339233 2.8712503910064697 0.3998875585750418 2.0017645359039307 156.95426731760742 277.25093268239254 106.03436730689737 214.51243269310265 244.60244447220188 454.9555555277981 UP 0.8 0.2 0.0 GO:0048584 5 positive regulation of response to stimulus 502 537 17 16 13 10 9 9 50 528 1960 0.17184 0.90244 0.33286 1.68 294228;24494;24408;25311;245920;502902;24232;298566;29650 rt1-s3;il1b;grin1;dcc;cxcl10;clec7a;c3;c1qa;adam10 RT1-S3_9763;IL1B_8892;GRIN1_32381;DCC_32537;CXCL10_8408;CLEC7A_32927;C3_8175;C1QA_8167;ADAM10_7983 268.66966666666667 268.455 144.319 88.04615828217607 268.9247190625555 87.37232018278692 179.38006666666666 178.963 57.6936 81.09602220972369 181.62319078731923 81.40740112765852 705.0527777777778 484.566 153.26 622.5400443430884 679.9639419423567 613.2258585430425 219.207;153.991;310.025;248.198;344.076;412.985;144.319;268.455;316.771 141.536;109.464;254.954;183.659;187.725;338.673;57.6936;161.753;178.963 484.566;258.668;447.21;299.409;2052.67;488.745;153.26;786.937;1374.01 5 4 5 24494;24408;502902;24232;298566 IL1B_8892;GRIN1_32381;CLEC7A_32927;C3_8175;C1QA_8167 257.95500000000004 268.455 112.4471982665641 184.50752 161.753 112.87246137589096 426.96399999999994 447.21 243.4362218518437 153.991;310.025;412.985;144.319;268.455 109.464;254.954;338.673;57.6936;161.753 258.668;447.21;488.745;153.26;786.937 4 294228;25311;245920;29650 RT1-S3_9763;DCC_32537;CXCL10_8408;ADAM10_7983 282.063 282.4845 58.160617815380014 172.97075 181.31099999999998 21.26011248598336 1052.66375 929.288 815.1490015902513 219.207;248.198;344.076;316.771 141.536;183.659;187.725;178.963 484.566;299.409;2052.67;1374.01 0 Exp 2,1(0.12);Exp 5,1(0.12);Linear,5(0.56);Poly 2,2(0.23) 2.0216054351562853 18.464061737060547 1.6434866189956665 2.8712503910064697 0.39153528922181907 1.933887243270874 211.14617658897836 326.1931567443551 126.39733215631384 232.3628011770195 298.3266154736267 1111.7789400819288 CONFLICT 0.5555555555555556 0.4444444444444444 0.0 GO:0002694 5 regulation of leukocyte activation 146 156 6 6 6 5 5 5 54 151 2337 0.85078 0.29268 0.40627 3.21 29142;294228;24494;24451;502902 vnn1;rt1-s3;il1b;hmox1;clec7a VNN1_10157;RT1-S3_9763;IL1B_8892;HMOX1_8815;CLEC7A_32927 216.24031999999997 219.207 61.2776 129.3367373653442 228.6268252435592 131.97688332338913 155.45347999999998 141.536 39.7754 111.0380841272579 166.4619252435592 115.39850331778108 385.9228 484.566 140.784 177.34581378115467 393.4377905390777 163.21350894470794 233.741;219.207;153.991;61.2776;412.985 147.819;141.536;109.464;39.7754;338.673 556.851;484.566;258.668;140.784;488.745 4 1 4 29142;24494;24451;502902 VNN1_10157;IL1B_8892;HMOX1_8815;CLEC7A_32927 215.49865 193.866 149.3329222927416 158.93285 128.6415 127.9006179222368 361.262 373.7065 194.63046141341798 233.741;153.991;61.2776;412.985 147.819;109.464;39.7754;338.673 556.851;258.668;140.784;488.745 1 294228 RT1-S3_9763 219.207 219.207 141.536 141.536 484.566 484.566 219.207 141.536 484.566 0 Linear,3(0.6);Poly 2,2(0.4) 2.013224546177946 10.278291583061218 1.5923793315887451 2.8712503910064697 0.4926540887512332 1.929691195487976 102.87167119911697 329.608968800883 58.12430795364351 252.78265204635653 230.4723403052451 541.3732596947549 UP 0.8 0.2 0.0 GO:1901566 5 organonitrogen compound biosynthetic process 169 188 4 4 4 3 3 3 56 185 2303 0.3554 0.82358 0.7988 1.6 29483;24494;64564 slc1a3;il1b;bbox1 SLC1A3_32817;IL1B_8892;BBOX1_8133 303.8913333333333 303.435 153.991 150.12902015377753 257.5898413654619 135.33301182769517 186.03333333333333 189.179 109.464 75.04596209212941 163.0496147446931 68.59520449087093 580.8580000000001 491.171 258.668 375.16184320770134 562.860815547906 409.0570843692444 303.435;153.991;454.248 189.179;109.464;259.457 992.735;258.668;491.171 3 0 3 29483;24494;64564 SLC1A3_32817;IL1B_8892;BBOX1_8133 303.8913333333333 303.435 150.12902015377753 186.03333333333333 189.179 75.04596209212941 580.8580000000001 491.171 375.16184320770134 303.435;153.991;454.248 189.179;109.464;259.457 992.735;258.668;491.171 0 0 Exp 2,1(0.34);Linear,1(0.34);Power,1(0.34) 2.3733836782859874 7.325240969657898 1.6762725114822388 2.8712503910064697 0.6645678721667142 2.7777180671691895 134.00435414337528 473.77831252329145 101.11083275898196 270.9558339076847 156.3224093153404 1005.3935906846596 UP 1.0 0.0 0.0 GO:0045917 7 positive regulation of complement activation 2 3 2 2 2 2 2 2 57 1 2487 0.99999 0.0015595 0.0015595 66.67 24494;24232 il1b;c3 IL1B_8892;C3_8175 149.155 149.155 144.319 6.839136787636285 149.43417896087234 6.827730971238656 83.5788 83.5788 57.6936 36.607200904740054 85.07313483001924 36.546150069625476 205.964 205.964 153.26 74.5347115913116 209.00656574727387 74.4104080041701 0.0 144.319 0.0 144.319 153.991;144.319 109.464;57.6936 258.668;153.26 2 0 2 24494;24232 IL1B_8892;C3_8175 149.155 149.155 6.839136787636285 83.5788 83.5788 36.607200904740054 205.964 205.964 74.5347115913116 153.991;144.319 109.464;57.6936 258.668;153.26 0 0 Exp 5,1(0.5);Linear,1(0.5) 2.226013689381293 4.597027063369751 1.7257766723632812 2.8712503910064697 0.80997223412357 2.2985135316848755 139.67643999999999 158.63356000000002 32.84380800000002 134.31379199999998 102.66416 309.26384 UP 1.0 0.0 0.0 GO:0009605 3 response to external stimulus 571 616 26 25 24 19 18 18 41 598 1890 0.90102 0.15985 0.28073 2.92 29142;78968;294228;362282;25211;681410;24494;24451;24450;24408;304729;80841;25086;25279;245920;502902;24232;298566 vnn1;srebf1;rt1-s3;pck1;lyz2;loc681410;il1b;hmox1;hmgcs2;grin1;gli2;fabp7;cyp2e1;cyp24a1;cxcl10;clec7a;c3;c1qa VNN1_10157;SREBF1_32750;RT1-S3_9763;PCK1_9439;LYZ2_32611;LOC681410_33126;IL1B_8892;HMOX1_8815;HMGCS2_8812;GRIN1_32381;GLI2_8713;FABP7_8592;CYP2E1_8421;CYP24A1_32574;CXCL10_8408;CLEC7A_32927;C3_8175;C1QA_8167 249.82670000000002 230.86950000000002 61.2776 92.65543977451199 247.37254154086534 92.61377302413618 167.3088333333333 155.1605 39.7754 77.52217356557159 164.92854221410354 76.87005906494278 670.0425555555555 486.65549999999996 140.784 643.1592284488868 671.768585797661 639.0122785670433 233.741;177.986;219.207;227.854;214.715;410.591;153.991;61.2776;269.456;310.025;273.717;227.998;357.376;189.111;344.076;412.985;144.319;268.455 147.819;117.256;141.536;148.568;139.536;326.66;109.464;39.7754;162.134;254.954;163.744;194.92;191.769;127.579;187.725;338.673;57.6936;161.753 556.851;348.781;484.566;506.507;464.331;495.344;258.668;140.784;795.183;447.21;831.582;274.42;2610.68;364.247;2052.67;488.745;153.26;786.937 14 4 14 29142;362282;25211;681410;24494;24451;24450;24408;80841;25086;25279;502902;24232;298566 VNN1_10157;PCK1_9439;LYZ2_32611;LOC681410_33126;IL1B_8892;HMOX1_8815;HMGCS2_8812;GRIN1_32381;FABP7_8592;CYP2E1_8421;CYP24A1_32574;CLEC7A_32927;C3_8175;C1QA_8167 248.70675714285713 230.86950000000002 100.14436880344844 171.5212857142857 155.1605 86.96471705944326 595.9404999999999 476.538 612.6785263500126 233.741;227.854;214.715;410.591;153.991;61.2776;269.456;310.025;227.998;357.376;189.111;412.985;144.319;268.455 147.819;148.568;139.536;326.66;109.464;39.7754;162.134;254.954;194.92;191.769;127.579;338.673;57.6936;161.753 556.851;506.507;464.331;495.344;258.668;140.784;795.183;447.21;274.42;2610.68;364.247;488.745;153.26;786.937 4 78968;294228;304729;245920 SREBF1_32750;RT1-S3_9763;GLI2_8713;CXCL10_8408 253.7465 246.462 71.85835572151657 152.56525000000002 152.64 30.16377497788794 929.39975 658.074 775.9509358932324 177.986;219.207;273.717;344.076 117.256;141.536;163.744;187.725 348.781;484.566;831.582;2052.67 0 Exp 2,4(0.23);Exp 5,1(0.06);Linear,10(0.56);Poly 2,3(0.17) 2.0579123766262772 38.8094824552536 1.5622447729110718 5.283818244934082 0.8472005705278963 1.9233027696609497 207.02207067812552 292.63132932187443 131.49541631458308 203.12225035208363 372.9181510338639 967.166960077247 UP 0.7777777777777778 0.2222222222222222 0.0 GO:0007017 3 microtubule-based process 97 110 8 8 7 7 6 6 53 104 2384 0.98769 0.039614 0.039614 5.45 246118;366669;313506;25595;311024;84488 tubb3;syne2;stil;map2;kif5c;fgf13 TUBB3_32820;SYNE2_9977;STIL_33274;MAP2_32650;KIF5C_8965;FGF13_32529 247.11333333333332 266.78700000000003 145.437 60.17579756901177 262.79408777561616 42.76338018403057 170.57183333333333 171.06099999999998 104.718 49.09671017254284 188.2848533398184 46.55407973351582 598.5745000000001 427.7525 237.081 398.789766608297 589.3730439040207 375.8668997532942 4.5 296.95450000000005 282.273;276.757;311.636;145.437;256.817;209.76 238.208;164.88;177.242;104.718;208.309;130.074 354.06;858.911;1285.89;237.081;372.239;483.266 3 3 3 246118;25595;311024 TUBB3_32820;MAP2_32650;KIF5C_8965 228.17566666666667 256.817 72.77545743815931 183.745 208.309 70.05310554857653 321.1266666666666 354.06 73.35103662753085 282.273;145.437;256.817 238.208;104.718;208.309 354.06;237.081;372.239 3 366669;313506;84488 SYNE2_9977;STIL_33274;FGF13_32529 266.051 276.757 51.77493284399326 157.39866666666668 164.88 24.45777621398411 876.0223333333333 858.911 401.58550725883197 276.757;311.636;209.76 164.88;177.242;130.074 858.911;1285.89;483.266 0 Exp 2,3(0.5);Linear,3(0.5) 1.9812326498813966 12.068562626838684 1.6343638896942139 2.545419454574585 0.3860251122787564 1.9371711611747742 198.96266702303032 295.26399964363634 131.28628326246624 209.85738340420042 279.4762286742525 917.6727713257476 CONFLICT 0.5 0.5 0.0 GO:0010975 8 regulation of neuron projection development 121 127 6 6 6 5 5 5 54 122 2366 0.92927 0.16835 0.21554 3.94 25595;24408;84488;25311;29650 map2;grin1;fgf13;dcc;adam10 MAP2_32650;GRIN1_32381;FGF13_32529;DCC_32537;ADAM10_7983 246.03820000000002 248.198 145.437 71.65684465352902 248.59853424954005 52.82708743129232 170.47359999999998 178.963 104.718 57.74683818444096 178.29718596472244 55.29799263208944 568.1952 447.21 237.081 461.8090823822112 454.32789627745916 274.9163896501042 145.437;310.025;209.76;248.198;316.771 104.718;254.954;130.074;183.659;178.963 237.081;447.21;483.266;299.409;1374.01 2 3 2 25595;24408 MAP2_32650;GRIN1_32381 227.731 227.731 116.38129090193146 179.836 179.836 106.23289437834215 342.14549999999997 342.14549999999997 148.58364082394812 145.437;310.025 104.718;254.954 237.081;447.21 3 84488;25311;29650 FGF13_32529;DCC_32537;ADAM10_7983 258.243 248.198 54.20807180669678 164.232 178.963 29.674733815149818 718.895 483.266 574.7456798715411 209.76;248.198;316.771 130.074;183.659;178.963 483.266;299.409;1374.01 0 Exp 2,2(0.4);Linear,2(0.4);Poly 2,1(0.2) 1.8479348789585792 9.283890724182129 1.6434866189956665 2.1256394386291504 0.2028050142536046 1.9169143438339233 183.22820632621415 308.8481936737859 119.85626457889259 221.09093542110742 163.40169167329748 972.9887083267025 DOWN 0.4 0.6 0.0 GO:0031099 4 regeneration 111 120 8 8 6 4 3 3 56 117 2371 0.69841 0.53233 0.75598 2.5 338475;24503;24451 nrep;ina;hmox1 NREP_9364;INA_32322;HMOX1_8815 196.3152 222.026 61.2776 124.19450037872046 183.94392262218318 141.60468470071902 143.90946666666665 142.777 39.7754 104.70489329851462 140.8569258804019 120.4792754991608 365.86133333333333 459.059 140.784 195.8798835162338 317.68504916593497 199.7952589106107 222.026;305.642;61.2776 142.777;249.176;39.7754 497.741;459.059;140.784 2 1 2 24503;24451 INA_32322;HMOX1_8815 183.4598 183.4598 172.79172432058198 144.4757 144.4757 148.06858424453176 299.92150000000004 299.92150000000004 225.05441078214844 305.642;61.2776 249.176;39.7754 459.059;140.784 1 338475 NREP_9364 222.026 222.026 142.777 142.777 497.741 497.741 222.026 142.777 497.741 0 Exp 2,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 1.6104837432017007 4.836293697357178 1.5347857475280762 1.7091286182403564 0.08882834891595918 1.5923793315887451 55.77589267797032 336.8545073220297 25.424725937184448 262.39420739614883 144.20237851855026 587.5202881481164 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0048732 5 gland development 137 157 6 6 5 5 4 4 55 153 2335 0.7027 0.49833 0.78227 2.55 24451;24450;304729;25315 hmox1;hmgcs2;gli2;ephx1 HMOX1_8815;HMGCS2_8812;GLI2_8713;EPHX1_8567 154.24 165.3668 12.5094 136.96599453285233 166.96318369328645 128.00208361352247 92.23384999999999 100.95469999999999 3.282 82.99408235504907 100.84985796082371 75.9640912003328 457.2364 467.9835 61.3966 412.7847709645306 488.74497818516664 403.11476008667563 61.2776;269.456;273.717;12.5094 39.7754;162.134;163.744;3.282 140.784;795.183;831.582;61.3966 3 1 3 24451;24450;25315 HMOX1_8815;HMGCS2_8812;EPHX1_8567 114.41433333333335 61.2776 136.46619777400312 68.39713333333333 39.7754 83.203919320266 332.45453333333336 140.784 402.6956856206103 61.2776;269.456;12.5094 39.7754;162.134;3.282 140.784;795.183;61.3966 1 304729 GLI2_8713 273.717 273.717 163.744 163.744 831.582 831.582 273.717 163.744 831.582 0 Hill,1(0.25);Linear,2(0.5);Poly 2,1(0.25) 1.935550075978257 7.800051689147949 1.5923793315887451 2.1981756687164307 0.2671882625155795 2.0047483444213867 20.013325357804746 288.46667464219524 10.899649292051933 173.5680507079481 52.707324454760055 861.76547554524 UP 0.75 0.25 0.0 GO:0021846 5 cell proliferation in forebrain 4 4 1 1 1 1 1 1 58 3 2485 0.99693 0.089539 0.089539 25.0 80841 fabp7 FABP7_8592 227.998 227.998 227.998 227.998 194.92 194.92 194.92 194.92000000000002 274.42 274.42 274.42 274.42 0.0 227.998 0.0 227.998 227.998 194.92 274.42 1 0 1 80841 FABP7_8592 227.998 227.998 194.92 194.92 274.42 274.42 227.998 194.92 274.42 0 0 Exp 2,1(1) 5.283818244934082 5.283818244934082 5.283818244934082 5.283818244934082 0.0 5.283818244934082 227.998 227.998 194.92 194.92 274.42 274.42 UP 1.0 0.0 0.0 GO:0006950 3 response to stress 773 821 33 32 28 21 18 18 41 803 1685 0.44826 0.66061 0.8881 2.19 29142;360243;78968;29483;294228;362282;338475;316273;25211;361680;681410;24494;24451;24450;25086;245920;24232;298566 vnn1;top2a;srebf1;slc1a3;rt1-s3;pck1;nrep;mcm3;lyz2;lsp1;loc681410;il1b;hmox1;hmgcs2;cyp2e1;cxcl10;c3;c1qa VNN1_10157;TOP2A_10059;SREBF1_32750;SLC1A3_32817;RT1-S3_9763;PCK1_9439;NREP_9364;MCM3_9207;LYZ2_32611;LSP1_32853;LOC681410_33126;IL1B_8892;HMOX1_8815;HMGCS2_8812;CYP2E1_8421;CXCL10_8408;C3_8175;C1QA_8167 237.3667555555556 228.4735 61.2776 82.15238508953384 233.86996907000514 80.372880277651 147.0615 142.1565 39.7754 60.26307017989591 142.51299736075623 54.18219807030826 717.3936111111111 531.679 140.784 631.8729611070044 743.0592322304549 654.7819791473412 233.741;203.468;177.986;303.435;219.207;227.854;222.026;229.093;214.715;231.535;410.591;153.991;61.2776;269.456;357.376;344.076;144.319;268.455 147.819;108.442;117.256;189.179;141.536;148.568;142.777;133.518;139.536;141.502;326.66;109.464;39.7754;162.134;191.769;187.725;57.6936;161.753 556.851;572.253;348.781;992.735;484.566;506.507;497.741;614.889;464.331;580.905;495.344;258.668;140.784;795.183;2610.68;2052.67;153.26;786.937 11 7 11 29142;29483;362282;25211;681410;24494;24451;24450;25086;24232;298566 VNN1_10157;SLC1A3_32817;PCK1_9439;LYZ2_32611;LOC681410_33126;IL1B_8892;HMOX1_8815;HMGCS2_8812;CYP2E1_8421;C3_8175;C1QA_8167 240.4736909090909 233.741 98.9431242456539 152.21372727272728 148.568 75.59713182211462 705.570909090909 506.507 686.6181276663841 233.741;303.435;227.854;214.715;410.591;153.991;61.2776;269.456;357.376;144.319;268.455 147.819;189.179;148.568;139.536;326.66;109.464;39.7754;162.134;191.769;57.6936;161.753 556.851;992.735;506.507;464.331;495.344;258.668;140.784;795.183;2610.68;153.26;786.937 7 360243;78968;294228;338475;316273;361680;245920 TOP2A_10059;SREBF1_32750;RT1-S3_9763;NREP_9364;MCM3_9207;LSP1_32853;CXCL10_8408 232.4844285714286 222.026 52.540115939654825 138.96514285714287 141.502 25.29070769029987 735.9721428571429 572.253 587.2365023595486 203.468;177.986;219.207;222.026;229.093;231.535;344.076 108.442;117.256;141.536;142.777;133.518;141.502;187.725 572.253;348.781;484.566;497.741;614.889;580.905;2052.67 0 Exp 2,6(0.34);Exp 5,1(0.06);Linear,9(0.5);Poly 2,2(0.12) 1.865210544332065 34.03097581863403 1.5347857475280762 2.8712503910064697 0.34152861240251614 1.7970152497291565 199.4142899450829 275.31922116602817 119.22138195484085 174.90161804515913 425.4831960882827 1009.3040261339397 UP 0.6111111111111112 0.3888888888888889 0.0 GO:0048608 4 reproductive structure development 101 108 6 6 5 2 2 2 57 106 2382 0.53917 0.72327 1.0 1.85 304729;50549 gli2;cyp4a1 GLI2_8713;CYP4A1_33111 324.661 324.661 273.717 72.04569572153515 319.50571075697206 71.67585547198935 180.418 180.418 163.744 23.580596939008974 178.73067091633465 23.459548016252057 2399.151 2399.151 831.582 2216.87733975563 2240.5205115537847 2205.4971946916257 273.717;375.605 163.744;197.092 831.582;3966.72 1 1 1 50549 CYP4A1_33111 375.605 375.605 197.092 197.092 3966.72 3966.72 375.605 197.092 3966.72 1 304729 GLI2_8713 273.717 273.717 163.744 163.744 831.582 831.582 273.717 163.744 831.582 0 Linear,2(1) 1.8642265316573523 3.779186964035034 1.5810112953186035 2.1981756687164307 0.4364011135363501 1.889593482017517 224.81075999999996 424.51124000000004 147.73696 213.09904 -673.2842399999995 5471.586239999999 CONFLICT 0.5 0.5 0.0 GO:1901361 5 organic cyclic compound catabolic process 75 89 5 5 5 3 3 3 56 86 2402 0.85112 0.34035 0.45999 3.37 24451;316098;25279 hmox1;exosc7;cyp24a1 HMOX1_8815;EXOSC7_8580;CYP24A1_32574 120.7912 111.985 61.2776 64.37007385206263 140.7965886607531 70.15378444152867 74.08013333333334 54.886 39.7754 46.94336064933287 91.56587867998265 50.61033930243053 292.85266666666666 364.247 140.784 131.77704328271045 300.45605564170955 125.47143740677413 61.2776;111.985;189.111 39.7754;54.886;127.579 140.784;373.527;364.247 3 0 3 24451;316098;25279 HMOX1_8815;EXOSC7_8580;CYP24A1_32574 120.7912 111.985 64.37007385206263 74.08013333333334 54.886 46.94336064933287 292.85266666666666 364.247 131.77704328271045 61.2776;111.985;189.111 39.7754;54.886;127.579 140.784;373.527;364.247 0 0 Linear,1(0.34);Poly 2,2(0.67) 1.8763818858335208 5.672557950019836 1.5923793315887451 2.1550474166870117 0.2828959310929573 1.9251312017440796 47.94960424616086 193.63279575383916 20.95871999451962 127.20154667214706 143.73290429858642 441.97242903474694 UP 1.0 0.0 0.0 GO:0016339 6 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules 8 8 1 1 1 1 1 1 58 7 2481 0.98649 0.17118 0.17118 12.5 29182 cdh22 CDH22_32502 307.062 307.062 307.062 307.062 216.691 216.691 216.691 216.691 757.755 757.755 757.755 757.755 0.0 307.062 0.0 307.062 307.062 216.691 757.755 1 0 1 29182 CDH22_32502 307.062 307.062 216.691 216.691 757.755 757.755 307.062 216.691 757.755 0 0 Exp 2,1(1) 1.7034999132156372 1.7034999132156372 1.7034999132156372 1.7034999132156372 0.0 1.7034999132156372 307.062 307.062 216.691 216.691 757.755 757.755 UP 1.0 0.0 0.0 GO:0016042 5 lipid catabolic process 77 87 6 6 6 5 5 5 54 82 2406 0.98593 0.048796 0.048796 5.75 362282;497009;171142;29740;25279 pck1;naaa;ehhadh;eci1;cyp24a1 PCK1_9439;NAAA_32484;EHHADH_8534;ECI1_8520;CYP24A1_32574 202.88320000000002 195.758 151.002 38.213961698572916 195.70739809530866 41.75188183753501 134.4602 130.778 107.821 19.383990138771892 130.5490561031646 20.912928480016724 429.33419999999995 388.001 250.969 147.32416415917663 407.6343175720744 163.00721334483322 3.5 239.2725 227.854;151.002;250.691;195.758;189.111 148.568;107.821;157.555;130.778;127.579 506.507;250.969;636.947;388.001;364.247 5 0 5 362282;497009;171142;29740;25279 PCK1_9439;NAAA_32484;EHHADH_8534;ECI1_8520;CYP24A1_32574 202.88320000000002 195.758 38.213961698572916 134.4602 130.778 19.383990138771892 429.33419999999995 388.001 147.32416415917663 227.854;151.002;250.691;195.758;189.111 148.568;107.821;157.555;130.778;127.579 506.507;250.969;636.947;388.001;364.247 0 0 Exp 2,2(0.4);Linear,3(0.6) 1.8973098928173902 9.601749897003174 1.5261523723602295 2.162810802459717 0.32415248437159955 2.1505277156829834 169.38718570934768 236.3792142906523 117.46938350681214 151.45101649318784 300.19887645100334 558.4695235489967 UP 1.0 0.0 0.0 GO:0048518 4 positive regulation of biological process 1152 1238 40 39 34 29 26 26 33 1212 1276 0.28346 0.79863 0.51193 2.1 29142;360243;366669;313506;78968;79212;29483;294228;291773;362282;25247;25595;681410;24494;24451;24408;304729;84488;25311;245920;502902;363198;24232;298566;29650;170924 vnn1;top2a;syne2;stil;srebf1;slc6a1;slc1a3;rt1-s3;taf4b;pck1;nsg1;map2;loc681410;il1b;hmox1;grin1;gli2;fgf13;dcc;cxcl10;clec7a;cenpq;c3;c1qa;adam10;abcc4 VNN1_10157;TOP2A_10059;SYNE2_9977;STIL_33274;SREBF1_32750;SLC6A1_32594;SLC1A3_32817;RT1-S3_9763;RGD1562997_32695;PCK1_9439;NSG1_32675;MAP2_32650;LOC681410_33126;IL1B_8892;HMOX1_8815;GRIN1_32381;GLI2_8713;FGF13_32529;DCC_32537;CXCL10_8408;CLEC7A_32927;CENPQ_8290;C3_8175;C1QA_8167;ADAM10_7983;ABCC4_32768 237.69727307692307 239.19650000000001 39.9715 91.28118591926184 230.1211019754918 98.36183973092399 155.16594230769232 157.05399999999997 12.1775 72.81711868078368 150.39146654474357 77.81354829379018 612.3136153846153 492.04449999999997 140.784 440.1346805589471 595.3753351340874 469.5191195950929 233.741;203.468;276.757;311.636;177.986;145.445;303.435;219.207;279.902;227.854;216.472;145.437;410.591;153.991;61.2776;310.025;273.717;209.76;248.198;344.076;412.985;39.9715;144.319;268.455;316.771;244.652 147.819;108.442;164.88;177.242;117.256;104.722;189.179;141.536;166.045;148.568;166.237;104.718;326.66;109.464;39.7754;254.954;163.744;130.074;183.659;187.725;338.673;12.1775;57.6936;161.753;178.963;152.355 556.851;572.253;858.911;1285.89;348.781;237.101;992.735;484.566;888.462;506.507;342.576;237.081;495.344;258.668;140.784;447.21;831.582;483.266;299.409;2052.67;488.745;177.403;153.26;786.937;1374.01;619.152 14 12 14 29142;79212;29483;362282;25247;25595;681410;24494;24451;24408;502902;24232;298566;170924 VNN1_10157;SLC6A1_32594;SLC1A3_32817;PCK1_9439;NSG1_32675;MAP2_32650;LOC681410_33126;IL1B_8892;HMOX1_8815;GRIN1_32381;CLEC7A_32927;C3_8175;C1QA_8167;ABCC4_32768 234.1914 230.7975 102.06662382533051 164.46935714285715 150.4615 89.1210521440164 447.35364285714286 467.97749999999996 244.51756081992187 233.741;145.445;303.435;227.854;216.472;145.437;410.591;153.991;61.2776;310.025;412.985;144.319;268.455;244.652 147.819;104.722;189.179;148.568;166.237;104.718;326.66;109.464;39.7754;254.954;338.673;57.6936;161.753;152.355 556.851;237.101;992.735;506.507;342.576;237.081;495.344;258.668;140.784;447.21;488.745;153.26;786.937;619.152 12 360243;366669;313506;78968;294228;291773;304729;84488;25311;245920;363198;29650 TOP2A_10059;SYNE2_9977;STIL_33274;SREBF1_32750;RT1-S3_9763;RGD1562997_32695;GLI2_8713;FGF13_32529;DCC_32537;CXCL10_8408;CENPQ_8290;ADAM10_7983 241.78745833333335 260.9575 81.18709987807006 144.31195833333334 164.312 49.24849528133194 804.7669166666668 701.9175 542.7442193508931 203.468;276.757;311.636;177.986;219.207;279.902;273.717;209.76;248.198;344.076;39.9715;316.771 108.442;164.88;177.242;117.256;141.536;166.045;163.744;130.074;183.659;187.725;12.1775;178.963 572.253;858.911;1285.89;348.781;484.566;888.462;831.582;483.266;299.409;2052.67;177.403;1374.01 0 Exp 2,7(0.27);Exp 4,1(0.04);Exp 5,1(0.04);Linear,13(0.5);Poly 2,4(0.16) 1.9294898211148548 51.11653506755829 1.5415009260177612 3.437419891357422 0.42670412574925154 1.9080458283424377 202.60991482602438 272.7846313278218 127.17594300804771 183.15594160733687 443.1312909012756 781.495939867955 CONFLICT 0.5384615384615384 0.46153846153846156 0.0 GO:0009611 4 response to wounding 115 120 7 7 6 5 4 4 55 116 2372 0.85775 0.30159 0.35766 3.33 29483;338475;24494;24451 slc1a3;nrep;il1b;hmox1 SLC1A3_32817;NREP_9364;IL1B_8892;HMOX1_8815 185.18240000000003 188.00850000000003 61.2776 102.73985134750123 168.45369361964032 107.79287958855656 120.29884999999999 126.12049999999999 39.7754 62.852107537907344 110.43547283047253 66.28954318090867 472.48199999999997 378.2045 140.784 377.28909821249806 430.40592204062096 398.6794333448306 303.435;222.026;153.991;61.2776 189.179;142.777;109.464;39.7754 992.735;497.741;258.668;140.784 3 1 3 29483;24494;24451 SLC1A3_32817;IL1B_8892;HMOX1_8815 172.90120000000002 153.991 122.18121108304663 112.80613333333334 109.464 74.75785119071662 464.0623333333333 258.668 461.6224114190443 303.435;153.991;61.2776 189.179;109.464;39.7754 992.735;258.668;140.784 1 338475 NREP_9364 222.026 222.026 142.777 142.777 497.741 497.741 222.026 142.777 497.741 0 Exp 2,1(0.25);Linear,2(0.5);Poly 2,1(0.25) 1.8519424857772309 7.67468798160553 1.5347857475280762 2.8712503910064697 0.6377038663157119 1.634325921535492 84.49734567944873 285.86745432055125 58.70378461285082 181.8939153871492 102.73868375175186 842.2253162482481 UP 0.75 0.25 0.0 GO:0072659 7 protein localization to plasma membrane 31 33 2 2 2 2 2 2 57 31 2457 0.96062 0.17686 0.17686 6.06 25247;84488 nsg1;fgf13 NSG1_32675;FGF13_32529 213.11599999999999 213.11599999999999 209.76 4.74610071532653 211.5408011646245 4.190819640366161 148.15550000000002 148.15550000000002 130.074 25.57110252804896 139.6686234380687 22.579352004543274 412.92100000000005 412.92100000000005 342.576 99.48285304513519 445.9386883416232 87.84362562617116 0.5 213.11599999999999 216.472;209.76 166.237;130.074 342.576;483.266 1 1 1 25247 NSG1_32675 216.472 216.472 166.237 166.237 342.576 342.576 216.472 166.237 342.576 1 84488 FGF13_32529 209.76 209.76 130.074 130.074 483.266 483.266 209.76 130.074 483.266 0 Exp 2,2(1) 2.3915977479071233 5.1013829708099365 1.6639630794525146 3.437419891357422 1.2540233378394354 2.5506914854049683 206.53823999999997 219.69376 112.71576000000005 183.59524 275.04480000000007 550.7972 CONFLICT 0.5 0.5 0.0 GO:0006644 5 phospholipid metabolic process 58 63 3 3 3 3 3 3 56 60 2428 0.94385 0.17765 0.17765 4.76 303872;24451;24450 pigz;hmox1;hmgcs2 PIGZ_32744;HMOX1_8815;HMGCS2_8812 228.6102 269.456 61.2776 151.10838655521408 229.18383648285135 169.19831915553445 138.1298 162.134 39.7754 88.81931619034228 138.4684900134499 99.45307957710499 465.1856666666667 459.59 140.784 327.2353838055007 372.3911943510424 261.3168318094145 355.097;61.2776;269.456 212.48;39.7754;162.134 459.59;140.784;795.183 3 0 3 303872;24451;24450 PIGZ_32744;HMOX1_8815;HMGCS2_8812 228.6102 269.456 151.10838655521408 138.1298 162.134 88.81931619034228 465.1856666666667 459.59 327.2353838055007 355.097;61.2776;269.456 212.48;39.7754;162.134 459.59;140.784;795.183 0 0 Linear,1(0.34);Poly 2,2(0.67) 1.7765158114131563 5.345747113227844 1.5923793315887451 1.9080781936645508 0.1671186097285328 1.8452895879745483 57.61496339725278 399.6054366027472 37.62128202100408 238.6383179789959 94.88397028685307 835.4873630464801 UP 1.0 0.0 0.0 GO:0044281 3 small molecule metabolic process 449 498 22 21 20 15 15 15 44 483 2005 0.90288 0.16185 0.24665 3.01 29142;286989;78968;29483;362282;497009;24494;24450;25315;171142;29740;50549;25086;25279;24232 vnn1;ugt2b7;srebf1;slc1a3;pck1;naaa;il1b;hmgcs2;ephx1;ehhadh;eci1;cyp4a1;cyp2e1;cyp24a1;c3 VNN1_10157;UGT2B7_33032;SREBF1_32750;SLC1A3_32817;PCK1_9439;NAAA_32484;IL1B_8892;HMGCS2_8812;EPHX1_8567;EHHADH_8534;ECI1_8520;CYP4A1_33111;CYP2E1_8421;CYP24A1_32574;C3_8175 203.13153799999998 195.758 4.13867 105.97088855336212 204.5710380999638 94.04655036389008 123.29248533333335 130.778 1.39768 61.24012051476964 126.01566968157469 52.71009208640939 793.8342799999999 388.001 16.5686 1077.3775502772507 763.3016098978014 1060.930656128946 233.741;4.13867;177.986;303.435;227.854;151.002;153.991;269.456;12.5094;250.691;195.758;375.605;357.376;189.111;144.319 147.819;1.39768;117.256;189.179;148.568;107.821;109.464;162.134;3.282;157.555;130.778;197.092;191.769;127.579;57.6936 556.851;16.5686;348.781;992.735;506.507;250.969;258.668;795.183;61.3966;636.947;388.001;3966.72;2610.68;364.247;153.26 14 1 14 29142;286989;29483;362282;497009;24494;24450;25315;171142;29740;50549;25086;25279;24232 VNN1_10157;UGT2B7_33032;SLC1A3_32817;PCK1_9439;NAAA_32484;IL1B_8892;HMGCS2_8812;EPHX1_8567;EHHADH_8534;ECI1_8520;CYP4A1_33111;CYP2E1_8421;CYP24A1_32574;C3_8175 204.92764785714283 211.806 109.73399545511899 123.72366285714286 139.2985 63.528243929107916 825.6238 447.254 1110.7230129547759 233.741;4.13867;303.435;227.854;151.002;153.991;269.456;12.5094;250.691;195.758;375.605;357.376;189.111;144.319 147.819;1.39768;189.179;148.568;107.821;109.464;162.134;3.282;157.555;130.778;197.092;191.769;127.579;57.6936 556.851;16.5686;992.735;506.507;250.969;258.668;795.183;61.3966;636.947;388.001;3966.72;2610.68;364.247;153.26 1 78968 SREBF1_32750 177.986 177.986 117.256 117.256 348.781 348.781 177.986 117.256 348.781 0 Exp 2,4(0.27);Exp 5,1(0.07);Hill,2(0.14);Linear,8(0.54) 1.9675378409237911 30.36329960823059 1.5261523723602295 3.570159435272217 0.5511274511369275 1.9080781936645508 149.50286909080347 256.76020690919654 92.30070832853741 154.28426233812922 248.6060128525993 1339.0625471474004 UP 0.9333333333333333 0.06666666666666667 0.0 GO:0046942 7 carboxylic acid transport 73 76 8 8 7 5 4 4 55 72 2416 0.97043 0.097163 0.097163 5.26 79212;29483;84487;170924 slc6a1;slc1a3;slc17a6;abcc4 SLC6A1_32594;SLC1A3_32817;SLC17A6_32912;ABCC4_32768 265.79075 274.0435 145.445 95.09615024235563 264.0080109968355 110.18105101187288 152.4265 157.90249999999997 104.722 35.345854264208434 145.46582507911393 36.13774478504101 575.2732500000001 535.6285 237.101 319.2337418949474 484.16145039556966 289.4152047794269 2.5 336.533 145.445;303.435;369.631;244.652 104.722;189.179;163.45;152.355 237.101;992.735;452.105;619.152 4 0 4 79212;29483;84487;170924 SLC6A1_32594;SLC1A3_32817;SLC17A6_32912;ABCC4_32768 265.79075 274.0435 95.09615024235563 152.4265 157.90249999999997 35.345854264208434 575.2732500000001 535.6285 319.2337418949474 145.445;303.435;369.631;244.652 104.722;189.179;163.45;152.355 237.101;992.735;452.105;619.152 0 0 Exp 2,1(0.25);Hill,1(0.25);Linear,2(0.5) 1.7631397309338885 7.087833285331726 1.5415009260177612 2.0017645359039307 0.20359935926107642 1.772283911705017 172.59652276249153 358.9849772375085 117.78756282107565 187.06543717892436 262.42418294295146 888.1223170570487 UP 1.0 0.0 0.0 GO:0051346 6 negative regulation of hydrolase activity 118 128 3 3 3 2 2 2 57 126 2362 0.42292 0.8067 0.76737 1.56 25595;24232 map2;c3 MAP2_32650;C3_8175 144.878 144.878 144.319 0.7905453813722293 144.52627430683918 0.6144428968891456 81.20580000000001 81.20580000000001 57.6936 33.25127212122867 66.4118020702403 25.844193703587123 195.1705 195.1705 153.26 59.27039750583753 168.8001964879852 46.067279123781894 145.437;144.319 104.718;57.6936 237.081;153.26 2 0 2 25595;24232 MAP2_32650;C3_8175 144.878 144.878 0.7905453813722293 81.20580000000001 81.20580000000001 33.25127212122867 195.1705 195.1705 59.27039750583753 145.437;144.319 104.718;57.6936 237.081;153.26 0 0 Exp 5,1(0.5);Linear,1(0.5) 1.9153012705685675 3.8514161109924316 1.7257766723632812 2.1256394386291504 0.28274567357060754 1.9257080554962158 143.78235999999995 145.97364000000002 35.12188800000002 127.28971200000001 113.02592000000001 277.31507999999997 UP 1.0 0.0 0.0 GO:1903900 6 regulation of viral life cycle 36 38 3 3 3 2 2 2 57 36 2452 0.94384 0.21936 0.21936 5.26 360243;24451 top2a;hmox1 TOP2A_10059;HMOX1_8815 132.37279999999998 132.37279999999998 61.2776 100.54379605962768 114.86069144448867 97.44591850847303 74.1087 74.1087 39.7754 48.55461850102418 65.65175105451651 47.05859121188153 356.5185 356.5185 140.784 305.09465577177855 303.3789633903701 295.6943156002963 0.5 132.37279999999998 203.468;61.2776 108.442;39.7754 572.253;140.784 1 1 1 24451 HMOX1_8815 61.2776 61.2776 39.7754 39.7754 140.784 140.784 61.2776 39.7754 140.784 1 360243 TOP2A_10059 203.468 203.468 108.442 108.442 572.253 572.253 203.468 108.442 572.253 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.8202594361624387 3.6731300354003906 1.5923793315887451 2.0807507038116455 0.3453307090361924 1.8365650177001953 -6.973792000000003 271.71939199999997 6.8154320000000155 141.40196799999998 -66.32111999999995 779.35812 CONFLICT 0.5 0.5 0.0 GO:0099185 6 postsynaptic intermediate filament cytoskeleton organization 3 3 1 1 1 1 1 1 58 2 2486 0.99844 0.067922 0.067922 33.33 24503 ina INA_32322 305.642 305.642 305.642 305.642 249.176 249.176 249.176 249.176 459.059 459.059 459.059 459.059 0.0 305.642 0.0 305.642 305.642 249.176 459.059 1 0 1 24503 INA_32322 305.642 305.642 249.176 249.176 459.059 459.059 305.642 249.176 459.059 0 0 Exp 2,1(1) 1.7091286182403564 1.7091286182403564 1.7091286182403564 1.7091286182403564 0.0 1.7091286182403564 305.642 305.642 249.176 249.176 459.059 459.059 UP 1.0 0.0 0.0 GO:0003012 4 muscle system process 68 71 2 2 2 2 2 2 57 69 2419 0.7743 0.49461 0.67957 2.82 365377;24584 trim72;mylpf TRIM72_33144;MYLPF_32295 217.6519 217.6519 82.0928 191.70951772309058 157.7708488834678 171.99144926413794 124.8868 124.8868 49.3056 106.88795810043337 91.50002109213736 95.89411647851496 1205.4135 1205.4135 193.467 1431.1084646959855 758.4024170576095 1283.9134009651282 82.0928;353.211 49.3056;200.468 193.467;2217.36 2 0 2 365377;24584 TRIM72_33144;MYLPF_32295 217.6519 217.6519 191.70951772309058 124.8868 124.8868 106.88795810043337 1205.4135 1205.4135 1431.1084646959855 82.0928;353.211 49.3056;200.468 193.467;2217.36 0 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.633677895810013 3.2679872512817383 1.601873517036438 1.6661137342453003 0.04542469321328328 1.6339936256408691 -48.043935999999974 483.347736 -23.252352000000002 273.02595199999996 -778.0016399999997 3188.8286399999997 UP 1.0 0.0 0.0 GO:0033280 6 response to vitamin D 17 20 3 3 3 3 3 3 56 17 2471 0.99905 0.010172 0.010172 15.0 24494;25279;245920 il1b;cyp24a1;cxcl10 IL1B_8892;CYP24A1_32574;CXCL10_8408 229.05933333333334 189.111 153.991 101.143357707431 230.52366545981175 97.1861525123977 141.58933333333334 127.579 109.464 40.968440418611586 142.58151107892832 39.03516944486468 891.8616666666667 364.247 258.668 1006.6745856344706 881.6272847212165 988.2618276686069 0.0 153.991 1.0 189.111 153.991;189.111;344.076 109.464;127.579;187.725 258.668;364.247;2052.67 2 1 2 24494;25279 IL1B_8892;CYP24A1_32574 171.551 171.551 24.833590155271636 118.5215 118.5215 12.80923934119406 311.4575 311.4575 74.65562685089476 153.991;189.111 109.464;127.579 258.668;364.247 1 245920 CXCL10_8408 344.076 344.076 187.725 187.725 2052.67 2052.67 344.076 187.725 2052.67 0 Linear,3(1) 2.481772150487251 7.496644020080566 2.1550474166870117 2.8712503910064697 0.35895315187092736 2.470346212387085 114.60484952704269 343.513817139624 95.22917872956276 187.94948793710392 -247.2978656180701 2031.0211989514034 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0009719 3 response to endogenous stimulus 481 515 20 20 16 12 10 10 49 505 1983 0.32871 0.78381 0.62419 1.94 360243;78968;79212;362282;25595;24494;24450;24408;25315;24232 top2a;srebf1;slc6a1;pck1;map2;il1b;hmgcs2;grin1;ephx1;c3 TOP2A_10059;SREBF1_32750;SLC6A1_32594;PCK1_9439;MAP2_32650;IL1B_8892;HMGCS2_8812;GRIN1_32381;EPHX1_8567;C3_8175 179.04904000000002 165.9885 12.5094 81.74213776133931 180.54265875552727 66.7974074667578 117.12336 108.953 3.282 65.78204426408978 121.26082972168433 61.335051178400036 361.74406000000005 303.72450000000003 61.3966 220.09789494493475 326.0150564839166 169.09027606576683 203.468;177.986;145.445;227.854;145.437;153.991;269.456;310.025;12.5094;144.319 108.442;117.256;104.722;148.568;104.718;109.464;162.134;254.954;3.282;57.6936 572.253;348.781;237.101;506.507;237.081;258.668;795.183;447.21;61.3966;153.26 8 2 8 79212;362282;25595;24494;24450;24408;25315;24232 SLC6A1_32594;PCK1_9439;MAP2_32650;IL1B_8892;HMGCS2_8812;GRIN1_32381;EPHX1_8567;C3_8175 176.12955 149.71800000000002 92.1725018924067 118.19194999999999 107.09299999999999 74.50884649924849 337.05082500000003 247.8845 235.01600208439143 145.445;227.854;145.437;153.991;269.456;310.025;12.5094;144.319 104.722;148.568;104.718;109.464;162.134;254.954;3.282;57.6936 237.101;506.507;237.081;258.668;795.183;447.21;61.3966;153.26 2 360243;78968 TOP2A_10059;SREBF1_32750 190.72699999999998 190.72699999999998 18.018494998195845 112.84899999999999 112.84899999999999 6.2324391693785035 460.51700000000005 460.51700000000005 158.0185666053199 203.468;177.986 108.442;117.256 572.253;348.781 0 Exp 2,4(0.4);Exp 5,1(0.1);Hill,1(0.1);Linear,4(0.4) 2.024895334691762 20.48338031768799 1.5889767408370972 2.8712503910064697 0.34226453629767367 2.041257619857788 128.3847381171305 229.71334188286954 76.35122655275842 157.89549344724153 225.32597137804697 498.162148621953 UP 0.8 0.2 0.0 GO:0008150 1 biological_process 2293 2547 87 84 75 65 59 59 0 2488 0 1.0 1.0 1.0 2.32 29142;286989;246118;365377;360243;311715;366669;313506;78968;79212;29483;84487;294228;291773;303872;362282;25247;338475;288280;497009;24584;24567;58827;316273;25595;25211;361680;681410;311024;24503;24494;24451;24450;24416;24408;304729;84488;80841;316098;25315;316137;171142;29740;25311;50549;25086;25279;245920;502902;363198;29182;500545;297594;24232;298566;64564;286921;29650;170924 vnn1;ugt2b7;tubb3;trim72;top2a;tcfl5;syne2;stil;srebf1;slc6a1;slc1a3;slc17a6;rt1-s3;taf4b;pigz;pck1;nsg1;nrep;ncam2;naaa;mylpf;mt1;mest;mcm3;map2;lyz2;lsp1;loc681410;kif5c;ina;il1b;hmox1;hmgcs2;grm3;grin1;gli2;fgf13;fabp7;exosc7;ephx1;adgre1;ehhadh;eci1;dcc;cyp4a1;cyp2e1;cyp24a1;cxcl10;clec7a;cenpq;cdh22;cdca8;cdca3;c3;c1qa;bbox1;akr1b8;adam10;abcc4 VNN1_10157;UGT2B7_33032;TUBB3_32820;TRIM72_33144;TOP2A_10059;TCFL5_9994;SYNE2_9977;STIL_33274;SREBF1_32750;SLC6A1_32594;SLC1A3_32817;SLC17A6_32912;RT1-S3_9763;RGD1562997_32695;PIGZ_32744;PCK1_9439;NSG1_32675;NREP_9364;NCAM2_32618;NAAA_32484;MYLPF_32295;MT1A_9255;MEST_9219;MCM3_9207;MAP2_32650;LYZ2_32611;LSP1_32853;LOC681410_33126;KIF5C_8965;INA_32322;IL1B_8892;HMOX1_8815;HMGCS2_8812;GRM3_33234;GRIN1_32381;GLI2_8713;FGF13_32529;FABP7_8592;EXOSC7_8580;EPHX1_8567;EMR1_8558;EHHADH_8534;ECI1_8520;DCC_32537;CYP4A1_33111;CYP2E1_8421;CYP24A1_32574;CXCL10_8408;CLEC7A_32927;CENPQ_8290;CDH22_32502;CDCA8_33310;CDCA3_8260;C3_8175;C1QA_8167;BBOX1_8133;AKR1B8_8013;ADAM10_7983;ABCC4_32768 247.12950796610167 250.691 4.13867 101.77225898392594 247.04114461705976 100.67866873818255 160.98743864406785 163.45 1.39768 70.73529652412593 161.72111893279876 71.38566993261226 738.7651220338984 474.793 16.5686 1014.4095777654031 699.5798736366645 998.1258656926242 233.741;4.13867;282.273;82.0928;203.468;270.921;276.757;311.636;177.986;145.445;303.435;369.631;219.207;279.902;355.097;227.854;216.472;222.026;314.433;151.002;353.211;392.753;272.228;229.093;145.437;214.715;231.535;410.591;256.817;305.642;153.991;61.2776;269.456;286.986;310.025;273.717;209.76;227.998;111.985;12.5094;119.065;250.691;195.758;248.198;375.605;357.376;189.111;344.076;412.985;39.9715;307.062;453.898;183.234;144.319;268.455;454.248;297.921;316.771;244.652 147.819;1.39768;238.208;49.3056;108.442;228.673;164.88;177.242;117.256;104.722;189.179;163.45;141.536;166.045;212.48;148.568;166.237;142.777;261.826;107.821;200.468;211.395;198.842;133.518;104.718;139.536;141.502;326.66;208.309;249.176;109.464;39.7754;162.134;241.819;254.954;163.744;130.074;194.92;54.886;3.282;89.1701;157.555;130.778;183.659;197.092;191.769;127.579;187.725;338.673;12.1775;216.691;224.22;111.531;57.6936;161.753;259.457;212.377;178.963;152.355 556.851;16.5686;354.06;193.467;572.253;338.867;858.911;1285.89;348.781;237.101;992.735;452.105;484.566;888.462;459.59;506.507;342.576;497.741;415.493;250.969;2217.36;6610.49;543.288;614.889;237.081;464.331;580.905;495.344;372.239;459.059;258.668;140.784;795.183;363.86;447.21;831.582;483.266;274.42;373.527;61.3966;178.281;636.947;388.001;299.409;3966.72;2610.68;364.247;2052.67;488.745;177.403;757.755;474.793;407.422;153.26;786.937;491.171;681.163;1374.01;619.152 42 17 42 29142;286989;246118;365377;311715;79212;29483;84487;303872;362282;25247;288280;497009;24584;24567;58827;25595;25211;681410;311024;24503;24494;24451;24450;24416;24408;80841;316098;25315;316137;171142;29740;50549;25086;25279;502902;29182;24232;298566;64564;286921;170924 VNN1_10157;UGT2B7_33032;TUBB3_32820;TRIM72_33144;TCFL5_9994;SLC6A1_32594;SLC1A3_32817;SLC17A6_32912;PIGZ_32744;PCK1_9439;NSG1_32675;NCAM2_32618;NAAA_32484;MYLPF_32295;MT1A_9255;MEST_9219;MAP2_32650;LYZ2_32611;LOC681410_33126;KIF5C_8965;INA_32322;IL1B_8892;HMOX1_8815;HMGCS2_8812;GRM3_33234;GRIN1_32381;FABP7_8592;EXOSC7_8580;EPHX1_8567;EMR1_8558;EHHADH_8534;ECI1_8520;CYP4A1_33111;CYP2E1_8421;CYP24A1_32574;CLEC7A_32927;CDH22_32502;C3_8175;C1QA_8167;BBOX1_8133;AKR1B8_8013;ABCC4_32768 246.65251119047622 262.63599999999997 108.1833400686159 166.9754138095238 164.8435 78.20695419731858 746.5283142857143 449.6575 1169.8513183901512 233.741;4.13867;282.273;82.0928;270.921;145.445;303.435;369.631;355.097;227.854;216.472;314.433;151.002;353.211;392.753;272.228;145.437;214.715;410.591;256.817;305.642;153.991;61.2776;269.456;286.986;310.025;227.998;111.985;12.5094;119.065;250.691;195.758;375.605;357.376;189.111;412.985;307.062;144.319;268.455;454.248;297.921;244.652 147.819;1.39768;238.208;49.3056;228.673;104.722;189.179;163.45;212.48;148.568;166.237;261.826;107.821;200.468;211.395;198.842;104.718;139.536;326.66;208.309;249.176;109.464;39.7754;162.134;241.819;254.954;194.92;54.886;3.282;89.1701;157.555;130.778;197.092;191.769;127.579;338.673;216.691;57.6936;161.753;259.457;212.377;152.355 556.851;16.5686;354.06;193.467;338.867;237.101;992.735;452.105;459.59;506.507;342.576;415.493;250.969;2217.36;6610.49;543.288;237.081;464.331;495.344;372.239;459.059;258.668;140.784;795.183;363.86;447.21;274.42;373.527;61.3966;178.281;636.947;388.001;3966.72;2610.68;364.247;488.745;757.755;153.26;786.937;491.171;681.163;619.152 17 360243;366669;313506;78968;294228;291773;338475;316273;361680;304729;84488;25311;245920;363198;500545;297594;29650 TOP2A_10059;SYNE2_9977;STIL_33274;SREBF1_32750;RT1-S3_9763;RGD1562997_32695;NREP_9364;MCM3_9207;LSP1_32853;GLI2_8713;FGF13_32529;DCC_32537;CXCL10_8408;CENPQ_8290;CDCA8_33310;CDCA3_8260;ADAM10_7983 248.30797058823532 231.535 86.91165538574033 146.1936176470588 142.777 46.237169912152915 719.5854705882352 572.253 471.9727672316113 203.468;276.757;311.636;177.986;219.207;279.902;222.026;229.093;231.535;273.717;209.76;248.198;344.076;39.9715;453.898;183.234;316.771 108.442;164.88;177.242;117.256;141.536;166.045;142.777;133.518;141.502;163.744;130.074;183.659;187.725;12.1775;224.22;111.531;178.963 572.253;858.911;1285.89;348.781;484.566;888.462;497.741;614.889;580.905;831.582;483.266;299.409;2052.67;177.403;474.793;407.422;1374.01 0 Exp 2,23(0.39);Exp 4,1(0.02);Exp 5,1(0.02);Hill,3(0.06);Linear,22(0.38);Poly 2,7(0.12);Power,2(0.04) 1.9893287662206198 121.52000308036804 1.5261523723602295 5.283818244934082 0.6496862734395398 1.892825961112976 221.1602536183573 273.098762313846 142.93789424819977 179.03698303993576 479.9179607270198 997.6122833407771 UP 0.711864406779661 0.288135593220339 0.0 GO:0034097 5 response to cytokine 230 247 7 7 6 6 5 5 54 242 2246 0.4839 0.69173 1.0 2.02 362282;361680;24503;24494;29650 pck1;lsp1;ina;il1b;adam10 PCK1_9439;LSP1_32853;INA_32322;IL1B_8892;ADAM10_7983 247.15859999999998 231.535 153.991 66.26303731568619 233.4670746670445 73.84828697992414 165.5346 148.568 109.464 52.8808785933063 167.16055419382263 65.17360079496173 635.8298000000001 506.507 258.668 429.57830108107174 483.958787900255 317.5444430177556 227.854;231.535;305.642;153.991;316.771 148.568;141.502;249.176;109.464;178.963 506.507;580.905;459.059;258.668;1374.01 3 2 3 362282;24503;24494 PCK1_9439;INA_32322;IL1B_8892 229.16233333333335 227.854 75.83396503106849 169.06933333333333 148.568 72.07696745378045 408.07800000000003 459.059 131.54975960069243 227.854;305.642;153.991 148.568;249.176;109.464 506.507;459.059;258.668 2 361680;29650 LSP1_32853;ADAM10_7983 274.153 274.153 60.270953601216284 160.23250000000002 160.23250000000002 26.488927130029076 977.4575 977.4575 560.809923692957 231.535;316.771 141.502;178.963 580.905;1374.01 0 Exp 2,3(0.6);Linear,2(0.4) 1.9770466027412654 10.1183021068573 1.6434866189956665 2.8712503910064697 0.5163618529651096 1.7316256761550903 189.07648691327617 305.2407130867239 119.18246621613787 211.88673378386216 259.28781711255 1012.37178288745 UP 0.6 0.4 0.0 GO:0021965 12 spinal cord ventral commissure morphogenesis 2 2 2 2 2 2 2 2 57 0 2488 1.0 5.2771E-4 5.2771E-4 100.0 304729;25311 gli2;dcc GLI2_8713;DCC_32537 260.9575 260.9575 248.198 18.044657949100255 259.59870222591667 17.94204608505694 173.7015 173.7015 163.744 14.082031547329832 174.7619043132908 14.001953359611386 565.4955 565.4955 299.409 376.30313706438864 537.1591432529787 374.1632701603821 0.0 248.198 0.0 248.198 273.717;248.198 163.744;183.659 831.582;299.409 0 2 0 2 304729;25311 GLI2_8713;DCC_32537 260.9575 260.9575 18.044657949100255 173.7015 173.7015 14.082031547329832 565.4955 565.4955 376.30313706438864 273.717;248.198 163.744;183.659 831.582;299.409 0 Linear,1(0.5);Poly 2,1(0.5) 2.0618011262483895 4.132062911987305 1.933887243270874 2.1981756687164307 0.1868801378216684 2.0660314559936523 235.94888 285.96611999999993 154.18480000000002 193.2182 43.965959999999995 1087.02504 DOWN 0.0 1.0 0.0 GO:0072347 5 response to anesthetic 42 44 3 3 3 3 3 3 56 41 2447 0.98232 0.080066 0.080066 6.82 79212;24494;24408 slc6a1;il1b;grin1 SLC6A1_32594;IL1B_8892;GRIN1_32381 203.15366666666668 153.991 145.445 92.6518750233007 187.5615015851827 84.77167867690666 156.38 109.464 104.722 85.40050789076143 142.32511930585684 77.8976686199578 314.32633333333337 258.668 237.101 115.58475471416347 293.80078558318036 106.62607667471222 1.5 232.00799999999998 145.445;153.991;310.025 104.722;109.464;254.954 237.101;258.668;447.21 3 0 3 79212;24494;24408 SLC6A1_32594;IL1B_8892;GRIN1_32381 203.15366666666668 153.991 92.6518750233007 156.38 109.464 85.40050789076143 314.32633333333337 258.668 115.58475471416347 145.445;153.991;310.025 104.722;109.464;254.954 237.101;258.668;447.21 0 0 Exp 2,1(0.34);Linear,2(0.67) 2.2251651786730724 6.789929270744324 1.9169143438339233 2.8712503910064697 0.528198589271534 2.0017645359039307 98.3082000948393 307.9991332384941 59.74022780946275 253.01977219053725 183.5298704063926 445.122796260274 UP 1.0 0.0 0.0 GO:0048585 5 negative regulation of response to stimulus 377 396 15 15 13 9 8 8 51 388 2100 0.41842 0.71962 0.85554 2.02 29142;365377;294228;24494;24451;24408;304729;80841 vnn1;trim72;rt1-s3;il1b;hmox1;grin1;gli2;fabp7 VNN1_10157;TRIM72_33144;RT1-S3_9763;IL1B_8892;HMOX1_8815;GRIN1_32381;GLI2_8713;FABP7_8592 195.25617499999998 223.6025 61.2776 88.57100283110644 185.56012184707527 88.96856465715157 137.68975 144.6775 39.7754 71.7317383440552 128.40477636091387 70.53299390479026 398.4435 360.815 140.784 228.60444790448486 387.8276372264889 224.53271932419565 233.741;82.0928;219.207;153.991;61.2776;310.025;273.717;227.998 147.819;49.3056;141.536;109.464;39.7754;254.954;163.744;194.92 556.851;193.467;484.566;258.668;140.784;447.21;831.582;274.42 6 2 6 29142;365377;24494;24451;24408;80841 VNN1_10157;TRIM72_33144;IL1B_8892;HMOX1_8815;GRIN1_32381;FABP7_8592 178.18756666666664 190.99450000000002 96.37010986511673 132.70633333333333 128.6415 83.87546932071773 311.90000000000003 266.544 158.65386580225518 233.741;82.0928;153.991;61.2776;310.025;227.998 147.819;49.3056;109.464;39.7754;254.954;194.92 556.851;193.467;258.668;140.784;447.21;274.42 2 294228;304729 RT1-S3_9763;GLI2_8713 246.462 246.462 38.544390642478525 152.64 152.64 15.70342739659099 658.074 658.074 245.37736678023134 219.207;273.717 141.536;163.744 484.566;831.582 0 Exp 2,2(0.25);Linear,4(0.5);Poly 2,2(0.25) 2.2172960119230387 19.24345862865448 1.5923793315887451 5.283818244934082 1.230706334770231 1.9233027696609497 133.87960141599913 256.63274858400086 87.98219136280709 187.3973086371929 240.0286997837854 556.8583002162146 UP 0.75 0.25 0.0 GO:0007188 7 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 35 35 4 4 3 3 3 3 56 32 2456 0.99204 0.045736 0.045736 8.57 24416;316137;245920 grm3;adgre1;cxcl10 GRM3_33234;EMR1_8558;CXCL10_8408 250.04233333333332 286.986 119.065 116.96629176960926 284.2600005077574 88.95108470784227 172.90470000000002 187.725 89.1701 77.39607636611815 199.53346533709447 63.2200654422128 864.937 363.86 178.281 1032.7836902163976 971.4197258674188 1029.7960824564598 0.5 203.0255 286.986;119.065;344.076 241.819;89.1701;187.725 363.86;178.281;2052.67 2 1 2 24416;316137 GRM3_33234;EMR1_8558 203.0255 203.0255 118.73807780362625 165.49455 165.49455 107.93907233066714 271.07050000000004 271.07050000000004 131.22416934581827 286.986;119.065 241.819;89.1701 363.86;178.281 1 245920 CXCL10_8408 344.076 344.076 187.725 187.725 2052.67 2052.67 344.076 187.725 2052.67 0 Exp 2,1(0.34);Linear,2(0.67) 3.036164193283827 9.22710371017456 2.470346212387085 3.667783737182617 0.5988290877744014 3.0889737606048584 117.6825140563129 382.4021526103538 85.32279477256962 260.48660522743035 -303.7677654597409 2033.6417654597408 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0050789 3 regulation of biological process 1644 1779 58 56 50 42 37 37 22 1742 746 0.14385 0.90981 0.2508 2.08 29142;246118;365377;360243;311715;366669;313506;78968;79212;29483;294228;291773;362282;25247;338475;24567;58827;25595;361680;681410;24494;24451;24416;24408;304729;84488;80841;316098;316137;25311;245920;502902;363198;24232;298566;29650;170924 vnn1;tubb3;trim72;top2a;tcfl5;syne2;stil;srebf1;slc6a1;slc1a3;rt1-s3;taf4b;pck1;nsg1;nrep;mt1;mest;map2;lsp1;loc681410;il1b;hmox1;grm3;grin1;gli2;fgf13;fabp7;exosc7;adgre1;dcc;cxcl10;clec7a;cenpq;c3;c1qa;adam10;abcc4 VNN1_10157;TUBB3_32820;TRIM72_33144;TOP2A_10059;TCFL5_9994;SYNE2_9977;STIL_33274;SREBF1_32750;SLC6A1_32594;SLC1A3_32817;RT1-S3_9763;RGD1562997_32695;PCK1_9439;NSG1_32675;NREP_9364;MT1A_9255;MEST_9219;MAP2_32650;LSP1_32853;LOC681410_33126;IL1B_8892;HMOX1_8815;GRM3_33234;GRIN1_32381;GLI2_8713;FGF13_32529;FABP7_8592;EXOSC7_8580;EMR1_8558;DCC_32537;CXCL10_8408;CLEC7A_32927;CENPQ_8290;C3_8175;C1QA_8167;ADAM10_7983;ABCC4_32768 234.59437567567565 233.741 39.9715 90.24235261219717 231.60664222170067 96.99182202518988 157.45438378378378 161.753 12.1775 71.643481576928 157.67480315055883 77.9777433967739 708.8935135135134 484.566 140.784 1070.2160006622917 697.0751156950188 1098.1944410039732 233.741;282.273;82.0928;203.468;270.921;276.757;311.636;177.986;145.445;303.435;219.207;279.902;227.854;216.472;222.026;392.753;272.228;145.437;231.535;410.591;153.991;61.2776;286.986;310.025;273.717;209.76;227.998;111.985;119.065;248.198;344.076;412.985;39.9715;144.319;268.455;316.771;244.652 147.819;238.208;49.3056;108.442;228.673;164.88;177.242;117.256;104.722;189.179;141.536;166.045;148.568;166.237;142.777;211.395;198.842;104.718;141.502;326.66;109.464;39.7754;241.819;254.954;163.744;130.074;194.92;54.886;89.1701;183.659;187.725;338.673;12.1775;57.6936;161.753;178.963;152.355 556.851;354.06;193.467;572.253;338.867;858.911;1285.89;348.781;237.101;992.735;484.566;888.462;506.507;342.576;497.741;6610.49;543.288;237.081;580.905;495.344;258.668;140.784;363.86;447.21;831.582;483.266;274.42;373.527;178.281;299.409;2052.67;488.745;177.403;153.26;786.937;1374.01;619.152 23 14 23 29142;246118;365377;311715;79212;29483;362282;25247;24567;58827;25595;681410;24494;24451;24416;24408;80841;316098;316137;502902;24232;298566;170924 VNN1_10157;TUBB3_32820;TRIM72_33144;TCFL5_9994;SLC6A1_32594;SLC1A3_32817;PCK1_9439;NSG1_32675;MT1A_9255;MEST_9219;MAP2_32650;LOC681410_33126;IL1B_8892;HMOX1_8815;GRM3_33234;GRIN1_32381;FABP7_8592;EXOSC7_8580;EMR1_8558;CLEC7A_32927;C3_8175;C1QA_8167;ABCC4_32768 231.5209304347826 233.741 99.92321909452842 165.64303043478262 161.753 83.67034946233088 673.6178695652173 363.86 1310.6707289780127 233.741;282.273;82.0928;270.921;145.445;303.435;227.854;216.472;392.753;272.228;145.437;410.591;153.991;61.2776;286.986;310.025;227.998;111.985;119.065;412.985;144.319;268.455;244.652 147.819;238.208;49.3056;228.673;104.722;189.179;148.568;166.237;211.395;198.842;104.718;326.66;109.464;39.7754;241.819;254.954;194.92;54.886;89.1701;338.673;57.6936;161.753;152.355 556.851;354.06;193.467;338.867;237.101;992.735;506.507;342.576;6610.49;543.288;237.081;495.344;258.668;140.784;363.86;447.21;274.42;373.527;178.281;488.745;153.26;786.937;619.152 14 360243;366669;313506;78968;294228;291773;338475;361680;304729;84488;25311;245920;363198;29650 TOP2A_10059;SYNE2_9977;STIL_33274;SREBF1_32750;RT1-S3_9763;RGD1562997_32695;NREP_9364;LSP1_32853;GLI2_8713;FGF13_32529;DCC_32537;CXCL10_8408;CENPQ_8290;ADAM10_7983 239.64360714285718 239.8665 74.90305520064908 144.00160714285715 153.26049999999998 45.309585227282774 766.8463571428572 576.579 508.7338484740035 203.468;276.757;311.636;177.986;219.207;279.902;222.026;231.535;273.717;209.76;248.198;344.076;39.9715;316.771 108.442;164.88;177.242;117.256;141.536;166.045;142.777;141.502;163.744;130.074;183.659;187.725;12.1775;178.963 572.253;858.911;1285.89;348.781;484.566;888.462;497.741;580.905;831.582;483.266;299.409;2052.67;177.403;1374.01 0 Exp 2,14(0.38);Exp 4,1(0.03);Exp 5,1(0.03);Linear,15(0.41);Poly 2,6(0.17) 2.0355556493657154 78.49827802181244 1.5347857475280762 5.283818244934082 0.736982498526706 1.9169143438339233 205.5163029679393 263.67244838341213 134.3692767799609 180.53949078760667 364.04635716804785 1053.7406698589793 UP 0.6216216216216216 0.3783783783783784 0.0 GO:1901570 5 fatty acid derivative biosynthetic process 18 23 2 2 2 2 2 2 57 21 2467 0.98496 0.097858 0.097858 8.7 24450;50549 hmgcs2;cyp4a1 HMGCS2_8812;CYP4A1_33111 322.5305 322.5305 269.456 75.05867771617103 348.2297315789474 65.67270432229255 179.613 179.613 162.134 24.719038856719312 188.07651578947366 21.627960675076757 2380.9515 2380.9515 795.183 2242.615319484039 3148.7972999999993 1962.179687497866 0.5 322.5305 269.456;375.605 162.134;197.092 795.183;3966.72 2 0 2 24450;50549 HMGCS2_8812;CYP4A1_33111 322.5305 322.5305 75.05867771617103 179.613 179.613 24.719038856719312 2380.9515 2380.9515 2242.615319484039 269.456;375.605 162.134;197.092 795.183;3966.72 0 0 Linear,2(1) 1.7368630275686026 3.4890894889831543 1.5810112953186035 1.9080781936645508 0.2312712217220705 1.7445447444915771 218.50448 426.55652000000003 145.35415999999998 213.87184000000002 -727.1547599999994 5489.05776 UP 1.0 0.0 0.0 GO:0009636 4 response to toxic substance 240 257 15 15 12 12 9 9 50 248 2240 0.93242 0.13412 0.18707 3.5 78968;79212;24494;24451;24450;24408;25315;25311;25086 srebf1;slc6a1;il1b;hmox1;hmgcs2;grin1;ephx1;dcc;cyp2e1 SREBF1_32750;SLC6A1_32594;IL1B_8892;HMOX1_8815;HMGCS2_8812;GRIN1_32381;EPHX1_8567;DCC_32537;CYP2E1_8421 192.9182222222222 177.986 12.5094 113.76667273672219 195.2090164818152 97.30945732581112 129.66837777777778 117.256 3.282 78.07115987952557 135.28406424202433 68.25529932690861 577.6902888888889 299.409 61.3966 790.7621206717928 517.1553686048577 737.7359756421981 177.986;145.445;153.991;61.2776;269.456;310.025;12.5094;248.198;357.376 117.256;104.722;109.464;39.7754;162.134;254.954;3.282;183.659;191.769 348.781;237.101;258.668;140.784;795.183;447.21;61.3966;299.409;2610.68 7 2 7 79212;24494;24451;24450;24408;25315;25086 SLC6A1_32594;IL1B_8892;HMOX1_8815;HMGCS2_8812;GRIN1_32381;EPHX1_8567;CYP2E1_8421 187.1542857142857 153.991 129.11975111277425 123.72862857142857 109.464 87.02952495656697 650.1460857142857 258.668 897.7610127584353 145.445;153.991;61.2776;269.456;310.025;12.5094;357.376 104.722;109.464;39.7754;162.134;254.954;3.282;191.769 237.101;258.668;140.784;795.183;447.21;61.3966;2610.68 2 78968;25311 SREBF1_32750;DCC_32537 213.09199999999998 213.09199999999998 49.64738132066996 150.45749999999998 150.45749999999998 46.95401159113043 324.095 324.095 34.91127600074178 177.986;248.198 117.256;183.659 348.781;299.409 0 Exp 2,2(0.23);Hill,1(0.12);Linear,4(0.45);Poly 2,2(0.23) 1.9409895683889085 17.723584055900574 1.5889767408370972 2.8712503910064697 0.37950766945762116 1.9169143438339233 118.59066270089708 267.24578174354735 78.66188665648772 180.67486889906783 61.059036716650894 1094.321541061127 UP 0.7777777777777778 0.2222222222222222 0.0 GO:0000302 5 response to reactive oxygen species 109 115 5 5 4 4 3 3 56 112 2376 0.72481 0.50313 0.74775 2.61 24494;24451;25086 il1b;hmox1;cyp2e1 IL1B_8892;HMOX1_8815;CYP2E1_8421 190.88153333333332 153.991 61.2776 151.45708701758835 178.99845120916737 145.21119634511575 113.66946666666666 109.464 39.7754 76.08401982448966 108.33803282982366 73.57530555602166 1003.3773333333332 258.668 140.784 1393.212315503037 881.4609530471017 1329.6970261684914 153.991;61.2776;357.376 109.464;39.7754;191.769 258.668;140.784;2610.68 3 0 3 24494;24451;25086 IL1B_8892;HMOX1_8815;CYP2E1_8421 190.88153333333332 153.991 151.45708701758835 113.66946666666666 109.464 76.08401982448966 1003.3773333333332 258.668 1393.212315503037 153.991;61.2776;357.376 109.464;39.7754;191.769 258.668;140.784;2610.68 0 0 Linear,2(0.67);Poly 2,1(0.34) 2.0222983875264884 6.272544503211975 1.5923793315887451 2.8712503910064697 0.6844652092940948 1.8089147806167603 19.491705011182148 362.2713616554845 27.572293186338726 199.7666401469946 -573.1908172388679 2579.9454839055343 UP 1.0 0.0 0.0 GO:0001774 5 microglial cell activation 18 19 2 2 1 2 1 1 58 18 2470 0.92989 0.36039 0.36039 5.26 298566 c1qa C1QA_8167 268.455 268.455 268.455 268.455 161.753 161.753 161.753 161.753 786.937 786.937 786.937 786.9370000000001 0.0 268.455 268.455 161.753 786.937 1 0 1 298566 C1QA_8167 268.455 268.455 161.753 161.753 786.937 786.937 268.455 161.753 786.937 0 0 Linear,1(1) 2.0174295902252197 2.0174295902252197 2.0174295902252197 2.0174295902252197 0.0 2.0174295902252197 268.455 268.455 161.753 161.753 786.937 786.937 UP 1.0 0.0 0.0 GO:0051234 3 establishment of localization 596 632 18 18 16 15 13 13 46 619 1869 0.37247 0.73819 0.76038 2.06 365377;366669;79212;29483;84487;25247;311024;24408;84488;363198;500545;29650;170924 trim72;syne2;slc6a1;slc1a3;slc17a6;nsg1;kif5c;grin1;fgf13;cenpq;cdca8;adam10;abcc4 TRIM72_33144;SYNE2_9977;SLC6A1_32594;SLC1A3_32817;SLC17A6_32912;NSG1_32675;KIF5C_8965;GRIN1_32381;FGF13_32529;CENPQ_8290;CDCA8_33310;ADAM10_7983;ABCC4_32768 248.13286923076924 256.817 39.9715 113.11066013203897 231.68190153057606 128.91797399492742 153.75585384615385 164.88 12.1775 67.30985890091455 138.78622907386693 74.13174860248535 540.3821538461539 452.105 177.403 346.7401451538424 433.61707436249594 258.684695363297 82.0928;276.757;145.445;303.435;369.631;216.472;256.817;310.025;209.76;39.9715;453.898;316.771;244.652 49.3056;164.88;104.722;189.179;163.45;166.237;208.309;254.954;130.074;12.1775;224.22;178.963;152.355 193.467;858.911;237.101;992.735;452.105;342.576;372.239;447.21;483.266;177.403;474.793;1374.01;619.152 8 5 8 365377;79212;29483;84487;25247;311024;24408;170924 TRIM72_33144;SLC6A1_32594;SLC1A3_32817;SLC17A6_32912;NSG1_32675;KIF5C_8965;GRIN1_32381;ABCC4_32768 241.07122499999997 250.7345 92.93305350845304 161.06395 164.8435 62.8041580635959 457.07312500000006 409.7245 253.9706155283308 82.0928;145.445;303.435;369.631;216.472;256.817;310.025;244.652 49.3056;104.722;189.179;163.45;166.237;208.309;254.954;152.355 193.467;237.101;992.735;452.105;342.576;372.239;447.21;619.152 5 366669;84488;363198;500545;29650 SYNE2_9977;FGF13_32529;CENPQ_8290;CDCA8_33310;ADAM10_7983 259.43149999999997 276.757 151.6864861688411 142.0629 164.88 80.07180741247193 673.6766 483.266 460.1296075827984 276.757;209.76;39.9715;453.898;316.771 164.88;130.074;12.1775;224.22;178.963 858.911;483.266;177.403;474.793;1374.01 0 Exp 2,5(0.39);Exp 4,1(0.08);Hill,1(0.08);Linear,4(0.31);Poly 2,1(0.08);Power,1(0.08) 1.909961080624371 25.40148389339447 1.5415009260177612 3.437419891357422 0.4937697354758994 1.8682953119277954 186.6452139677701 309.6205244937683 117.16579774472869 190.34590994757906 351.89206382127304 728.8722438710347 UP 0.6153846153846154 0.38461538461538464 0.0 GO:0042981 7 regulation of apoptotic process 428 455 17 17 15 12 11 11 48 444 2044 0.64102 0.49125 0.86361 2.42 29142;360243;313506;24567;24494;24451;24408;304729;245920;502902;29650 vnn1;top2a;stil;mt1;il1b;hmox1;grin1;gli2;cxcl10;clec7a;adam10 VNN1_10157;TOP2A_10059;STIL_33274;MT1A_9255;IL1B_8892;HMOX1_8815;GRIN1_32381;GLI2_8713;CXCL10_8408;CLEC7A_32927;ADAM10_7983 274.04005454545455 310.025 61.2776 104.4614621095872 283.0661327288985 111.07699786952851 174.3814909090909 177.242 39.7754 79.0953032371134 184.05169365551376 87.08851764684765 1329.013909090909 572.253 140.784 1840.626902661452 1379.6039385306408 1899.313098786929 233.741;203.468;311.636;392.753;153.991;61.2776;310.025;273.717;344.076;412.985;316.771 147.819;108.442;177.242;211.395;109.464;39.7754;254.954;163.744;187.725;338.673;178.963 556.851;572.253;1285.89;6610.49;258.668;140.784;447.21;831.582;2052.67;488.745;1374.01 6 5 6 29142;24567;24494;24451;24408;502902 VNN1_10157;MT1A_9255;IL1B_8892;HMOX1_8815;GRIN1_32381;CLEC7A_32927 260.7954333333333 271.883 137.80022423612633 183.68006666666668 179.607 107.12002075068257 1417.1246666666666 467.97749999999996 2548.9136854375956 233.741;392.753;153.991;61.2776;310.025;412.985 147.819;211.395;109.464;39.7754;254.954;338.673 556.851;6610.49;258.668;140.784;447.21;488.745 5 360243;313506;304729;245920;29650 TOP2A_10059;STIL_33274;GLI2_8713;CXCL10_8408;ADAM10_7983 289.93359999999996 311.636 54.456215855492765 163.2232 177.242 31.803527189605827 1223.2810000000002 1285.89 568.2848746509089 203.468;311.636;273.717;344.076;316.771 108.442;177.242;163.744;187.725;178.963 572.253;1285.89;831.582;2052.67;1374.01 0 Exp 2,3(0.28);Linear,6(0.55);Poly 2,2(0.19) 2.001229917268077 22.350210070610046 1.5923793315887451 2.8712503910064697 0.3835727612121586 1.929691195487976 212.30727538690195 335.77283370400727 127.63915370062726 221.12382811755452 241.27292020748973 2416.7548979743287 CONFLICT 0.5454545454545454 0.45454545454545453 0.0 GO:1903827 6 regulation of cellular protein localization 137 147 4 4 4 4 4 4 55 143 2345 0.74809 0.4463 0.77389 2.72 78968;25595;363198;29650 srebf1;map2;cenpq;adam10 SREBF1_32750;MAP2_32650;CENPQ_8290;ADAM10_7983 170.04137500000002 161.7115 39.9715 114.18734251321013 108.97906885486998 98.84971597502594 103.278625 110.987 12.1775 68.8597086054622 62.33780867705061 67.58848211203501 534.31875 292.931 177.403 564.2826669394071 320.40273387258503 351.9860680867291 177.986;145.437;39.9715;316.771 117.256;104.718;12.1775;178.963 348.781;237.081;177.403;1374.01 1 3 1 25595 MAP2_32650 145.437 145.437 104.718 104.718 237.081 237.081 145.437 104.718 237.081 3 78968;363198;29650 SREBF1_32750;CENPQ_8290;ADAM10_7983 178.24283333333332 177.986 138.3999287304128 102.79883333333333 117.256 84.32738584578163 633.398 348.781 647.0874791162321 177.986;39.9715;316.771 117.256;12.1775;178.963 348.781;177.403;1374.01 0 Exp 2,1(0.25);Exp 4,1(0.25);Linear,2(0.5) 1.8019166837455105 7.257280111312866 1.5889767408370972 2.1256394386291504 0.24771232302019316 1.7713319659233093 58.13777933705404 281.94497066294593 35.79611056664703 170.76113943335298 -18.67826360061906 1087.315763600619 DOWN 0.25 0.75 0.0 GO:0051100 5 negative regulation of binding 52 53 3 3 2 3 2 2 57 51 2437 0.87731 0.3491 0.3491 3.77 25595;24451 map2;hmox1 MAP2_32650;HMOX1_8815 103.35730000000001 103.35730000000001 61.2776 59.50968244059112 76.08410380634976 45.318294793000824 72.2467 72.2467 39.7754 45.92135284788549 51.20101441852306 34.970400114828955 188.9325 188.9325 140.784 68.09226170792091 157.72592089107172 51.85416998792295 145.437;61.2776 104.718;39.7754 237.081;140.784 2 0 2 25595;24451 MAP2_32650;HMOX1_8815 103.35730000000001 103.35730000000001 59.50968244059112 72.2467 72.2467 45.92135284788549 188.9325 188.9325 68.09226170792091 145.437;61.2776 104.718;39.7754 237.081;140.784 0 0 Linear,1(0.5);Poly 2,1(0.5) 1.839789202186751 3.7180187702178955 1.5923793315887451 2.1256394386291504 0.37707183782453474 1.8590093851089478 20.881088000000005 185.833512 8.602952000000009 135.890448 94.56144000000002 283.30356 UP 1.0 0.0 0.0 GO:0019637 4 organophosphate metabolic process 156 173 5 4 4 4 4 4 55 169 2319 0.62756 0.57714 1.0 2.31 303872;362282;24451;24450 pigz;pck1;hmox1;hmgcs2 PIGZ_32744;PCK1_9439;HMOX1_8815;HMGCS2_8812 228.42115 248.65500000000003 61.2776 123.3800603196886 229.04104395587905 150.7149113901043 140.73935 155.351 39.7754 72.7082271169501 139.55293503414123 88.66181752235484 475.516 483.0485 140.784 267.98419248779084 386.7920135814512 237.6554880495568 355.097;227.854;61.2776;269.456 212.48;148.568;39.7754;162.134 459.59;506.507;140.784;795.183 4 0 4 303872;362282;24451;24450 PIGZ_32744;PCK1_9439;HMOX1_8815;HMGCS2_8812 228.42115 248.65500000000003 123.3800603196886 140.73935 155.351 72.7082271169501 475.516 483.0485 267.98419248779084 355.097;227.854;61.2776;269.456 212.48;148.568;39.7754;162.134 459.59;506.507;140.784;795.183 0 0 Exp 2,1(0.25);Linear,1(0.25);Poly 2,2(0.5) 1.8660850792919508 7.508557915687561 1.5923793315887451 2.162810802459717 0.2342847741704764 1.8766838908195496 107.50869088670517 349.33360911329487 69.48528742538889 211.9934125746111 212.89149136196494 738.140508638035 UP 1.0 0.0 0.0 GO:0008037 3 cell recognition 38 40 2 2 2 2 2 2 57 38 2450 0.93631 0.23663 0.23663 5.0 288280;502902 ncam2;clec7a NCAM2_32618;CLEC7A_32927 363.709 363.709 314.433 69.68678749949639 360.4068931725781 69.5301411835234 300.2495 300.2495 261.826 54.33903481384253 297.6746460815926 54.216888135503766 452.119 452.119 415.493 51.79698593547631 449.6646010093929 51.680553433470415 1.0 412.985 314.433;412.985 261.826;338.673 415.493;488.745 2 0 2 288280;502902 NCAM2_32618;CLEC7A_32927 363.709 363.709 69.68678749949639 300.2495 300.2495 54.33903481384253 452.119 452.119 51.79698593547631 314.433;412.985 261.826;338.673 415.493;488.745 0 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.9059010922445523 3.8297168016433716 1.729861855506897 2.0998549461364746 0.2616246233763432 1.9148584008216858 267.12804 460.28996 224.93944000000005 375.55956 380.33204 523.90596 UP 1.0 0.0 0.0 GO:0048666 5 neuron development 37 39 2 2 2 2 2 2 57 37 2451 0.94013 0.22798 0.22798 5.13 25595;304729 map2;gli2 MAP2_32650;GLI2_8713 209.577 209.577 145.437 90.70765789061029 251.68534931506844 68.42260617603199 134.231 134.231 104.718 41.73768486631722 153.6064866438356 31.483573060075376 534.3315 534.3315 237.081 420.3756885221837 729.4784892123287 317.09781567085355 0.5 209.577 145.437;273.717 104.718;163.744 237.081;831.582 1 1 1 25595 MAP2_32650 145.437 145.437 104.718 104.718 237.081 237.081 145.437 104.718 237.081 1 304729 GLI2_8713 273.717 273.717 163.744 163.744 831.582 831.582 273.717 163.744 831.582 0 Linear,2(1) 2.1616033157031036 4.323815107345581 2.1256394386291504 2.1981756687164307 0.05129086017642356 2.1619075536727905 83.86260000000006 335.29139999999995 76.38552 192.07648 -48.27947999999992 1116.94248 CONFLICT 0.5 0.5 0.0 GO:0051649 4 establishment of localization in cell 242 254 9 9 9 8 8 8 51 246 2242 0.8728 0.22995 0.37471 3.15 366669;79212;84487;25247;311024;24408;363198;500545 syne2;slc6a1;slc17a6;nsg1;kif5c;grin1;cenpq;cdca8 SYNE2_9977;SLC6A1_32594;SLC17A6_32912;NSG1_32675;KIF5C_8965;GRIN1_32381;CENPQ_8290;CDCA8_33310 258.6270625 266.78700000000003 39.9715 128.63226416539885 249.6896587681655 143.1591152755983 162.3686875 165.55849999999998 12.1775 75.98036439245223 148.20621935443748 81.4411690558976 420.29225 409.7245 177.403 206.32723943203135 385.98068984389573 189.64692694983194 276.757;145.445;369.631;216.472;256.817;310.025;39.9715;453.898 164.88;104.722;163.45;166.237;208.309;254.954;12.1775;224.22 858.911;237.101;452.105;342.576;372.239;447.21;177.403;474.793 5 3 5 79212;84487;25247;311024;24408 SLC6A1_32594;SLC17A6_32912;NSG1_32675;KIF5C_8965;GRIN1_32381 259.678 256.817 85.94853789332318 179.5344 166.237 56.01008309492136 370.2462 372.239 88.20649799022749 145.445;369.631;216.472;256.817;310.025 104.722;163.45;166.237;208.309;254.954 237.101;452.105;342.576;372.239;447.21 3 366669;363198;500545 SYNE2_9977;CENPQ_8290;CDCA8_33310 256.87550000000005 276.757 207.6782183625668 133.7591666666667 164.88 109.39325917113597 503.70233333333334 474.793 341.6725050122314 276.757;39.9715;453.898 164.88;12.1775;224.22 858.911;177.403;474.793 0 Exp 2,3(0.38);Exp 4,1(0.13);Hill,1(0.13);Linear,2(0.25);Power,1(0.13) 2.1028194083850553 17.21014702320099 1.748702883720398 3.437419891357422 0.5482019461332552 1.9521566033363342 169.4894511546818 347.76467384531827 109.7169812190507 215.0203937809493 277.3147676570279 563.269732342972 UP 0.625 0.375 0.0 GO:0070507 6 regulation of microtubule cytoskeleton organization 50 53 4 4 4 3 3 3 56 50 2438 0.96729 0.12269 0.12269 5.66 313506;25595;84488 stil;map2;fgf13 STIL_33274;MAP2_32650;FGF13_32529 222.2776666666667 209.76 145.437 83.80361498368273 246.068843624498 70.11915151340571 137.34466666666665 130.074 104.718 36.80461369629268 147.2561415662651 31.69088560896919 668.7456666666667 483.266 237.081 548.4542913318605 791.1906717704151 510.87880765356306 1.5 260.698 311.636;145.437;209.76 177.242;104.718;130.074 1285.89;237.081;483.266 1 2 1 25595 MAP2_32650 145.437 145.437 104.718 104.718 237.081 237.081 145.437 104.718 237.081 2 313506;84488 STIL_33274;FGF13_32529 260.698 260.698 72.0372104401611 153.65800000000002 153.65800000000002 33.35281265500693 884.5780000000001 884.5780000000001 567.5408731430714 311.636;209.76 177.242;130.074 1285.89;483.266 0 Exp 2,1(0.34);Linear,2(0.67) 1.7947088915206235 5.423966407775879 1.6343638896942139 2.1256394386291504 0.27549133006269155 1.6639630794525146 127.44494891367644 317.1103844196569 95.69632556171615 178.99300777161716 48.111210498902665 1289.3801228344307 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0044092 4 negative regulation of molecular function 276 297 7 7 6 5 4 4 55 293 2195 0.16424 0.9269 0.30601 1.35 25595;24494;24451;24232 map2;il1b;hmox1;c3 MAP2_32650;IL1B_8892;HMOX1_8815;C3_8175 126.25614999999999 144.878 61.2776 43.5339155964252 121.65810599800731 47.176320616378824 77.91275 81.20580000000001 39.7754 34.531503953491516 72.24650191962805 34.955519284138376 197.44825 195.1705 140.784 59.11021155082535 189.58770448356032 61.62170652237232 145.437;153.991;61.2776;144.319 104.718;109.464;39.7754;57.6936 237.081;258.668;140.784;153.26 4 0 4 25595;24494;24451;24232 MAP2_32650;IL1B_8892;HMOX1_8815;C3_8175 126.25614999999999 144.878 43.5339155964252 77.91275 81.20580000000001 34.531503953491516 197.44825 195.1705 59.11021155082535 145.437;153.991;61.2776;144.319 104.718;109.464;39.7754;57.6936 237.081;258.668;140.784;153.26 0 0 Exp 5,1(0.25);Linear,2(0.5);Poly 2,1(0.25) 2.023708464587623 8.315045833587646 1.5923793315887451 2.8712503910064697 0.5748629070740646 1.9257080554962158 83.59291271550339 168.91938728449662 44.071876125578314 111.75362387442169 139.52024268019107 255.37625731980893 UP 1.0 0.0 0.0 GO:0051301 3 cell division 78 79 4 4 3 4 3 3 56 76 2412 0.89178 0.27602 0.42848 3.8 360243;500545;297594 top2a;cdca8;cdca3 TOP2A_10059;CDCA8_33310;CDCA3_8260 280.2 203.468 183.234 150.76670750533756 308.94221076797754 160.41822964970999 148.06433333333334 111.531 108.442 65.97082426598399 161.4463374805599 69.37522766781389 484.8226666666667 474.793 407.422 82.87195122798342 472.33244656742943 72.86598403901625 203.468;453.898;183.234 108.442;224.22;111.531 572.253;474.793;407.422 0 3 0 3 360243;500545;297594 TOP2A_10059;CDCA8_33310;CDCA3_8260 280.2 203.468 150.76670750533756 148.06433333333334 111.531 65.97082426598399 484.8226666666667 474.793 82.87195122798342 203.468;453.898;183.234 108.442;224.22;111.531 572.253;474.793;407.422 0 Exp 2,2(0.67);Power,1(0.34) 1.9855092912497607 5.960975527763367 1.892825961112976 2.0807507038116455 0.09396303251121578 1.9873988628387451 109.59140964044119 450.8085903595588 73.4113179620238 222.71734870464286 391.04422570116446 578.6011076321689 DOWN 0.0 1.0 0.0 GO:0043603 5 cellular amide metabolic process 114 134 4 3 3 3 3 3 56 131 2357 0.62322 0.6089 1.0 2.24 29142;24450;29650 vnn1;hmgcs2;adam10 VNN1_10157;HMGCS2_8812;ADAM10_7983 273.3226666666667 269.456 233.741 41.64983263271684 261.95809168184576 40.20126180029927 162.97199999999998 162.134 147.819 15.588902046007242 158.6581005869257 15.158788387251189 908.6813333333333 795.183 556.851 420.2363758319044 803.1326545233759 391.70837439072386 233.741;269.456;316.771 147.819;162.134;178.963 556.851;795.183;1374.01 2 1 2 29142;24450 VNN1_10157;HMGCS2_8812 251.5985 251.5985 25.254318690077955 154.9765 154.9765 10.122233572685554 676.017 676.017 168.526173373752 233.741;269.456 147.819;162.134 556.851;795.183 1 29650 ADAM10_7983 316.771 316.771 178.963 178.963 1374.01 1374.01 316.771 178.963 1374.01 0 Linear,3(1) 1.8222867554224136 5.481256008148193 1.6434866189956665 1.929691195487976 0.15936796145959484 1.9080781936645508 226.19144418555078 320.4538891477826 145.33149668643964 180.61250331356032 433.1391073020812 1384.2235593645855 UP 0.6666666666666666 0.3333333333333333 0.0 GO:1901214 6 regulation of neuron death 149 157 9 9 8 7 6 6 53 151 2337 0.93232 0.15246 0.17486 3.82 24567;24494;24451;24408;25311;298566 mt1;il1b;hmox1;grin1;dcc;c1qa MT1A_9255;IL1B_8892;HMOX1_8815;GRIN1_32381;DCC_32537;C1QA_8167 239.11659999999998 258.3265 61.2776 117.00293657203656 240.50655351602416 109.55562668109357 160.16673333333333 172.706 39.7754 76.4567908980404 159.7432044341229 70.91916427422574 1423.9163333333333 373.30949999999996 140.784 2550.6467155734967 1314.0413195231458 2391.543436330549 392.753;153.991;61.2776;310.025;248.198;268.455 211.395;109.464;39.7754;254.954;183.659;161.753 6610.49;258.668;140.784;447.21;299.409;786.937 5 1 5 24567;24494;24451;24408;298566 MT1A_9255;IL1B_8892;HMOX1_8815;GRIN1_32381;C1QA_8167 237.30032 268.455 130.71865746828945 155.46828 161.753 84.50730805730355 1648.8178 447.21 2784.4017870569974 392.753;153.991;61.2776;310.025;268.455 211.395;109.464;39.7754;254.954;161.753 6610.49;258.668;140.784;447.21;786.937 1 25311 DCC_32537 248.198 248.198 183.659 183.659 299.409 299.409 248.198 183.659 299.409 0 Exp 2,2(0.34);Linear,2(0.34);Poly 2,2(0.34) 2.0072925820876253 12.244857668876648 1.5923793315887451 2.8712503910064697 0.4322931372348008 1.9254007935523987 145.49475228382005 332.73844771617996 98.9885591435164 221.34490752315025 -617.0261026385551 3464.858769305222 UP 0.8333333333333334 0.16666666666666666 0.0 GO:0045087 5 innate immune response 79 87 5 5 4 3 3 3 56 84 2404 0.8597 0.32744 0.45304 3.45 29142;24232;298566 vnn1;c3;c1qa VNN1_10157;C3_8175;C1QA_8167 215.505 233.741 144.319 64.0456899096263 224.9539301271041 66.84445600281647 122.42186666666665 147.819 57.6936 56.48761340553639 127.87144068704912 56.970517953600734 499.016 556.851 153.26 320.7729734578648 555.8667273102028 340.3118219382304 233.741;144.319;268.455 147.819;57.6936;161.753 556.851;153.26;786.937 3 0 3 29142;24232;298566 VNN1_10157;C3_8175;C1QA_8167 215.505 233.741 64.0456899096263 122.42186666666665 147.819 56.48761340553639 499.016 556.851 320.7729734578648 233.741;144.319;268.455 147.819;57.6936;161.753 556.851;153.26;786.937 0 0 Exp 5,1(0.34);Linear,2(0.67) 1.8869349648204445 5.672897458076477 1.7257766723632812 2.0174295902252197 0.14963320885286055 1.929691195487976 143.0304792328743 287.9795207671257 58.50011460775742 186.3436187255759 136.02720935367643 862.0047906463235 UP 1.0 0.0 0.0 GO:0050896 2 response to stimulus 1203 1308 53 52 47 39 35 35 24 1273 1215 0.91517 0.134 0.23692 2.68 29142;360243;78968;79212;29483;294228;362282;338475;24584;24567;58827;316273;25595;25211;361680;681410;24503;24494;24451;24450;24408;304729;84488;80841;25315;316137;25311;25086;25279;245920;502902;24232;298566;29650;170924 vnn1;top2a;srebf1;slc6a1;slc1a3;rt1-s3;pck1;nrep;mylpf;mt1;mest;mcm3;map2;lyz2;lsp1;loc681410;ina;il1b;hmox1;hmgcs2;grin1;gli2;fgf13;fabp7;ephx1;adgre1;dcc;cyp2e1;cyp24a1;cxcl10;clec7a;c3;c1qa;adam10;abcc4 VNN1_10157;TOP2A_10059;SREBF1_32750;SLC6A1_32594;SLC1A3_32817;RT1-S3_9763;PCK1_9439;NREP_9364;MYLPF_32295;MT1A_9255;MEST_9219;MCM3_9207;MAP2_32650;LYZ2_32611;LSP1_32853;LOC681410_33126;INA_32322;IL1B_8892;HMOX1_8815;HMGCS2_8812;GRIN1_32381;GLI2_8713;FGF13_32529;FABP7_8592;EPHX1_8567;EMR1_8558;DCC_32537;CYP2E1_8421;CYP24A1_32574;CXCL10_8408;CLEC7A_32927;C3_8175;C1QA_8167;ADAM10_7983;ABCC4_32768 241.48882857142857 231.535 12.5094 91.73703373583508 243.64979333571168 85.96450686901596 158.1086028571429 148.568 3.282 68.41771544877602 159.96742286984556 65.94136135550126 818.2623600000001 495.344 61.3966 1160.8673243015405 817.2140643664038 1185.244880080601 233.741;203.468;177.986;145.445;303.435;219.207;227.854;222.026;353.211;392.753;272.228;229.093;145.437;214.715;231.535;410.591;305.642;153.991;61.2776;269.456;310.025;273.717;209.76;227.998;12.5094;119.065;248.198;357.376;189.111;344.076;412.985;144.319;268.455;316.771;244.652 147.819;108.442;117.256;104.722;189.179;141.536;148.568;142.777;200.468;211.395;198.842;133.518;104.718;139.536;141.502;326.66;249.176;109.464;39.7754;162.134;254.954;163.744;130.074;194.92;3.282;89.1701;183.659;191.769;127.579;187.725;338.673;57.6936;161.753;178.963;152.355 556.851;572.253;348.781;237.101;992.735;484.566;506.507;497.741;2217.36;6610.49;543.288;614.889;237.081;464.331;580.905;495.344;459.059;258.668;140.784;795.183;447.21;831.582;483.266;274.42;61.3966;178.281;299.409;2610.68;364.247;2052.67;488.745;153.26;786.937;1374.01;619.152 24 11 24 29142;79212;29483;362282;24584;24567;58827;25595;25211;681410;24503;24494;24451;24450;24408;80841;25315;316137;25086;25279;502902;24232;298566;170924 VNN1_10157;SLC6A1_32594;SLC1A3_32817;PCK1_9439;MYLPF_32295;MT1A_9255;MEST_9219;MAP2_32650;LYZ2_32611;LOC681410_33126;INA_32322;IL1B_8892;HMOX1_8815;HMGCS2_8812;GRIN1_32381;FABP7_8592;EPHX1_8567;EMR1_8558;CYP2E1_8421;CYP24A1_32574;CLEC7A_32927;C3_8175;C1QA_8167;ABCC4_32768 240.678 239.19650000000001 106.57296468028069 162.69187916666667 157.05399999999997 80.84898577336469 854.1296083333333 476.538 1367.0186355672583 233.741;145.445;303.435;227.854;353.211;392.753;272.228;145.437;214.715;410.591;305.642;153.991;61.2776;269.456;310.025;227.998;12.5094;119.065;357.376;189.111;412.985;144.319;268.455;244.652 147.819;104.722;189.179;148.568;200.468;211.395;198.842;104.718;139.536;326.66;249.176;109.464;39.7754;162.134;254.954;194.92;3.282;89.1701;191.769;127.579;338.673;57.6936;161.753;152.355 556.851;237.101;992.735;506.507;2217.36;6610.49;543.288;237.081;464.331;495.344;459.059;258.668;140.784;795.183;447.21;274.42;61.3966;178.281;2610.68;364.247;488.745;153.26;786.937;619.152 11 360243;78968;294228;338475;316273;361680;304729;84488;25311;245920;29650 TOP2A_10059;SREBF1_32750;RT1-S3_9763;NREP_9364;MCM3_9207;LSP1_32853;GLI2_8713;FGF13_32529;DCC_32537;CXCL10_8408;ADAM10_7983 243.25790909090912 229.093 49.85348838437389 148.10872727272726 141.536 26.848606113133407 740.0065454545455 572.253 523.4102159915036 203.468;177.986;219.207;222.026;229.093;231.535;273.717;209.76;248.198;344.076;316.771 108.442;117.256;141.536;142.777;133.518;141.502;163.744;130.074;183.659;187.725;178.963 572.253;348.781;484.566;497.741;614.889;580.905;831.582;483.266;299.409;2052.67;1374.01 0 Exp 2,13(0.38);Exp 5,1(0.03);Hill,1(0.03);Linear,16(0.46);Poly 2,4(0.12) 1.967437818777693 71.18985652923584 1.5347857475280762 5.283818244934082 0.6635752729336359 1.912996768951416 211.09630637524688 271.88135076761023 135.4417817194903 180.77542399479537 433.66647234296767 1202.858247657032 UP 0.6857142857142857 0.3142857142857143 0.0 GO:2001237 8 negative regulation of extrinsic apoptotic signaling pathway 46 48 3 3 2 2 2 2 57 46 2442 0.90191 0.3061 0.3061 4.17 24494;24451 il1b;hmox1 IL1B_8892;HMOX1_8815 107.63430000000001 107.63430000000001 61.2776 65.55827384686086 108.83106706065321 65.53642320866362 74.6197 74.6197 39.7754 49.27728163139686 75.51925735614307 49.260857464177576 199.726 199.726 140.784 83.35657579339495 201.24767527216176 83.3287929633701 153.991;61.2776 109.464;39.7754 258.668;140.784 2 0 2 24494;24451 IL1B_8892;HMOX1_8815 107.63430000000001 107.63430000000001 65.55827384686086 74.6197 74.6197 49.27728163139686 199.726 199.726 83.35657579339495 153.991;61.2776 109.464;39.7754 258.668;140.784 0 0 Linear,1(0.5);Poly 2,1(0.5) 2.1382515704319744 4.463629722595215 1.5923793315887451 2.8712503910064697 0.9042983983774973 2.2318148612976074 16.775168000000022 198.49343199999998 6.324871999999985 142.91452800000002 84.19968 315.25232 UP 1.0 0.0 0.0 GO:1901701 5 cellular response to oxygen-containing compound 359 378 16 16 14 8 7 7 52 371 2117 0.33314 0.79489 0.71001 1.85 78968;362282;24567;24494;24450;24408;245920 srebf1;pck1;mt1;il1b;hmgcs2;grin1;cxcl10 SREBF1_32750;PCK1_9439;MT1A_9255;IL1B_8892;HMGCS2_8812;GRIN1_32381;CXCL10_8408 268.02014285714284 269.456 153.991 87.3988559220097 276.6550864007448 95.81217476445674 170.2137142857143 162.134 109.464 51.98128743664802 173.56734993554855 55.041419327323304 1574.2155714285714 506.507 258.668 2303.706034506346 1826.4080595817813 2426.8251355566154 177.986;227.854;392.753;153.991;269.456;310.025;344.076 117.256;148.568;211.395;109.464;162.134;254.954;187.725 348.781;506.507;6610.49;258.668;795.183;447.21;2052.67 5 2 5 362282;24567;24494;24450;24408 PCK1_9439;MT1A_9255;IL1B_8892;HMGCS2_8812;GRIN1_32381 270.81579999999997 269.456 89.30515287316851 177.30300000000003 162.134 56.67863568400349 1723.6115999999997 506.507 2738.6202988315667 227.854;392.753;153.991;269.456;310.025 148.568;211.395;109.464;162.134;254.954 506.507;6610.49;258.668;795.183;447.21 2 78968;245920 SREBF1_32750;CXCL10_8408 261.031 261.031 117.44336528727376 152.4905 152.4905 49.829107763434735 1200.7255 1200.7255 1204.831466289165 177.986;344.076 117.256;187.725 348.781;2052.67 0 Exp 2,4(0.58);Linear,3(0.43) 2.083721748329662 14.831373453140259 1.5889767408370972 2.8712503910064697 0.42816126779941927 1.9169143438339233 203.27416431760628 332.7661213966794 131.7054376575399 208.72199091388865 -132.39374168014888 3280.824884537292 UP 0.7142857142857143 0.2857142857142857 0.0 GO:0009615 5 response to virus 66 68 4 4 4 2 2 2 57 66 2422 0.79265 0.47168 0.67051 2.94 304729;245920 gli2;cxcl10 GLI2_8713;CXCL10_8408 308.8965 308.8965 273.717 49.751326017504255 314.4669445797807 49.123667766843695 175.7345 175.7345 163.744 16.957127719634624 177.63311753958587 16.74319812272349 1442.126 1442.126 831.582 863.4396052255192 1538.801663824604 852.546528888684 273.717;344.076 163.744;187.725 831.582;2052.67 0 2 0 2 304729;245920 GLI2_8713;CXCL10_8408 308.8965 308.8965 49.751326017504255 175.7345 175.7345 16.957127719634624 1442.126 1442.126 863.4396052255192 273.717;344.076 163.744;187.725 831.582;2052.67 0 Linear,2(1) 2.3302907409538154 4.668521881103516 2.1981756687164307 2.470346212387085 0.19245363706874902 2.334260940551758 239.94467999999998 377.84832000000006 152.23312 199.23587999999998 245.4597600000002 2638.79224 DOWN 0.0 1.0 0.0 GO:0032501 2 multicellular organismal process 609 640 24 23 23 17 16 16 43 624 1864 0.70055 0.40992 0.76135 2.5 365377;313506;79212;29483;288280;24584;24494;24450;24416;24408;304729;84488;80841;24232;298566;29650 trim72;stil;slc6a1;slc1a3;ncam2;mylpf;il1b;hmgcs2;grm3;grin1;gli2;fgf13;fabp7;c3;c1qa;adam10 TRIM72_33144;STIL_33274;SLC6A1_32594;SLC1A3_32817;NCAM2_32618;MYLPF_32295;IL1B_8892;HMGCS2_8812;GRM3_33234;GRIN1_32381;GLI2_8713;FGF13_32529;FABP7_8592;C3_8175;C1QA_8167;ADAM10_7983 248.23317500000002 271.5865 82.0928 79.05000299243086 235.1067624808762 82.87690754161117 164.89132500000002 170.493 49.3056 62.879943710868496 161.98591876927557 69.59193428138495 694.4026250000001 465.238 153.26 557.9450932672945 569.2308418125745 468.9456607298269 82.0928;311.636;145.445;303.435;314.433;353.211;153.991;269.456;286.986;310.025;273.717;209.76;227.998;144.319;268.455;316.771 49.3056;177.242;104.722;189.179;261.826;200.468;109.464;162.134;241.819;254.954;163.744;130.074;194.92;57.6936;161.753;178.963 193.467;1285.89;237.101;992.735;415.493;2217.36;258.668;795.183;363.86;447.21;831.582;483.266;274.42;153.26;786.937;1374.01 12 4 12 365377;79212;29483;288280;24584;24494;24450;24416;24408;80841;24232;298566 TRIM72_33144;SLC6A1_32594;SLC1A3_32817;NCAM2_32618;MYLPF_32295;IL1B_8892;HMGCS2_8812;GRM3_33234;GRIN1_32381;FABP7_8592;C3_8175;C1QA_8167 238.32056666666668 268.95550000000003 86.18556341036717 165.68651666666668 175.6565 72.44848211830919 594.6411666666667 389.67650000000003 578.005376619352 82.0928;145.445;303.435;314.433;353.211;153.991;269.456;286.986;310.025;227.998;144.319;268.455 49.3056;104.722;189.179;261.826;200.468;109.464;162.134;241.819;254.954;194.92;57.6936;161.753 193.467;237.101;992.735;415.493;2217.36;258.668;795.183;363.86;447.21;274.42;153.26;786.937 4 313506;304729;84488;29650 STIL_33274;GLI2_8713;FGF13_32529;ADAM10_7983 277.971 292.67650000000003 49.36128463347232 162.50574999999998 170.493 22.666787838524417 993.6870000000001 1058.736 415.0645756200671 311.636;273.717;209.76;316.771 177.242;163.744;130.074;178.963 1285.89;831.582;483.266;1374.01 0 Exp 2,7(0.44);Exp 5,1(0.07);Linear,7(0.44);Poly 2,1(0.07) 2.0632493375201064 35.206926584243774 1.601873517036438 5.283818244934082 0.9876865716118257 1.8189700245857239 209.49867353370888 286.96767646629115 134.08015258167438 195.70249741832555 421.0095292990258 967.7957207009745 UP 0.75 0.25 0.0 GO:0043524 8 negative regulation of neuron apoptotic process 75 76 5 5 4 4 3 3 56 73 2415 0.90284 0.25696 0.25696 3.95 24567;24451;24408 mt1;hmox1;grin1 MT1A_9255;HMOX1_8815;GRIN1_32381 254.68519999999998 310.025 61.2776 172.52783920086637 252.74994220598975 174.40018642760285 168.70813333333334 211.395 39.7754 113.76328016479366 166.32205735573413 114.09195966946568 2399.4946666666665 447.21 140.784 3650.0459581196146 2434.5975888970047 3670.0368336464617 392.753;61.2776;310.025 211.395;39.7754;254.954 6610.49;140.784;447.21 3 0 3 24567;24451;24408 MT1A_9255;HMOX1_8815;GRIN1_32381 254.68519999999998 310.025 172.52783920086637 168.70813333333334 211.395 113.76328016479366 2399.4946666666665 447.21 3650.0459581196146 392.753;61.2776;310.025 211.395;39.7754;254.954 6610.49;140.784;447.21 0 0 Exp 2,2(0.67);Poly 2,1(0.34) 1.8007544300978204 5.4222904443740845 1.5923793315887451 1.9169143438339233 0.18624977078596375 1.912996768951416 59.45157096556366 449.91882903443627 39.972862896338 297.4434037703287 -1730.9211656240695 6529.9104989574025 UP 1.0 0.0 0.0 GO:0010557 7 positive regulation of macromolecule biosynthetic process 371 401 14 14 12 10 9 9 50 392 2096 0.5461 0.59784 1.0 2.24 360243;78968;291773;362282;24494;24408;304729;25311;502902 top2a;srebf1;taf4b;pck1;il1b;grin1;gli2;dcc;clec7a TOP2A_10059;SREBF1_32750;RGD1562997_32695;PCK1_9439;IL1B_8892;GRIN1_32381;GLI2_8713;DCC_32537;CLEC7A_32927 254.23622222222224 248.198 153.991 77.88203431757832 264.47543066723466 89.09738946480864 176.75611111111112 163.744 108.442 75.98812437717554 191.07047156398104 86.10268621426903 515.7352222222222 488.745 258.668 220.2675472157541 478.8234437935993 210.1874692801981 203.468;177.986;279.902;227.854;153.991;310.025;273.717;248.198;412.985 108.442;117.256;166.045;148.568;109.464;254.954;163.744;183.659;338.673 572.253;348.781;888.462;506.507;258.668;447.21;831.582;299.409;488.745 4 5 4 362282;24494;24408;502902 PCK1_9439;IL1B_8892;GRIN1_32381;CLEC7A_32927 276.21375 268.9395 111.24543659666826 212.91475000000003 201.76100000000002 103.96313111667672 425.2825 467.97749999999996 113.8216663220729 227.854;153.991;310.025;412.985 148.568;109.464;254.954;338.673 506.507;258.668;447.21;488.745 5 360243;78968;291773;304729;25311 TOP2A_10059;SREBF1_32750;RGD1562997_32695;GLI2_8713;DCC_32537 236.6542 248.198 44.498775906759526 147.8292 163.744 32.9959955100615 588.0974 572.253 269.4290351767976 203.468;177.986;279.902;273.717;248.198 108.442;117.256;166.045;163.744;183.659 572.253;348.781;888.462;831.582;299.409 0 Exp 2,4(0.45);Linear,3(0.34);Poly 2,2(0.23) 2.0261720133822827 18.49084782600403 1.5889767408370972 2.8712503910064697 0.3751122603632752 2.0807507038116455 203.35329313473775 305.11915130970675 127.11053651802303 226.40168570419917 371.8270913745962 659.6433530698482 CONFLICT 0.4444444444444444 0.5555555555555556 0.0 GO:0031667 5 response to nutrient levels 239 256 11 10 10 9 8 8 51 248 2240 0.86821 0.23648 0.37693 3.12 78968;362282;24494;24451;24450;24408;25279;245920 srebf1;pck1;il1b;hmox1;hmgcs2;grin1;cyp24a1;cxcl10 SREBF1_32750;PCK1_9439;IL1B_8892;HMOX1_8815;HMGCS2_8812;GRIN1_32381;CYP24A1_32574;CXCL10_8408 216.72207500000002 208.48250000000002 61.2776 91.17508445239925 213.31876822777645 95.51579909918641 143.431925 138.0735 39.7754 62.803760084789936 140.58243919221331 63.01898797216774 614.25625 405.7285 140.784 612.3588658476451 654.1676620291731 712.2768199810758 177.986;227.854;153.991;61.2776;269.456;310.025;189.111;344.076 117.256;148.568;109.464;39.7754;162.134;254.954;127.579;187.725 348.781;506.507;258.668;140.784;795.183;447.21;364.247;2052.67 6 2 6 362282;24494;24451;24450;24408;25279 PCK1_9439;IL1B_8892;HMOX1_8815;HMGCS2_8812;GRIN1_32381;CYP24A1_32574 201.95243333333335 208.48250000000002 88.50074865811399 140.41240000000002 138.0735 70.58105303209918 418.7665 405.7285 226.30730672848367 227.854;153.991;61.2776;269.456;310.025;189.111 148.568;109.464;39.7754;162.134;254.954;127.579 506.507;258.668;140.784;795.183;447.21;364.247 2 78968;245920 SREBF1_32750;CXCL10_8408 261.031 261.031 117.44336528727376 152.4905 152.4905 49.829107763434735 1200.7255 1200.7255 1204.831466289165 177.986;344.076 117.256;187.725 348.781;2052.67 0 Exp 2,3(0.38);Linear,4(0.5);Poly 2,1(0.13) 2.0450710445222 16.6658034324646 1.5889767408370972 2.8712503910064697 0.43521516180406067 2.0359808802604675 153.54096491828324 279.90318508171674 99.91113965283137 186.95271034716865 189.91320557063835 1038.5992944293616 UP 0.75 0.25 0.0 GO:0010648 6 negative regulation of cell communication 320 334 14 14 12 8 7 7 52 327 2161 0.48168 0.67205 1.0 2.1 29142;365377;78968;79212;24494;24451;304729 vnn1;trim72;srebf1;slc6a1;il1b;hmox1;gli2 VNN1_10157;TRIM72_33144;SREBF1_32750;SLC6A1_32594;IL1B_8892;HMOX1_8815;GLI2_8713 161.17862857142856 153.991 61.2776 76.09934667747845 149.3256084517458 71.86893467011686 104.5837142857143 109.464 39.7754 46.20505021630672 97.90016824256512 44.38302242249947 366.74771428571427 258.668 140.784 245.6651774670248 329.3633733030479 232.72507871309185 233.741;82.0928;177.986;145.445;153.991;61.2776;273.717 147.819;49.3056;117.256;104.722;109.464;39.7754;163.744 556.851;193.467;348.781;237.101;258.668;140.784;831.582 5 2 5 29142;365377;79212;24494;24451 VNN1_10157;TRIM72_33144;SLC6A1_32594;IL1B_8892;HMOX1_8815 135.30947999999998 145.445 67.92132649479105 90.2172 104.722 45.047003502785806 277.37420000000003 237.101 162.61644692558005 233.741;82.0928;145.445;153.991;61.2776 147.819;49.3056;104.722;109.464;39.7754 556.851;193.467;237.101;258.668;140.784 2 78968;304729 SREBF1_32750;GLI2_8713 225.8515 225.8515 67.69203926976942 140.5 140.5 32.8719800438003 590.1815 590.1815 341.3918610636464 177.986;273.717 117.256;163.744 348.781;831.582 0 Exp 2,1(0.15);Linear,4(0.58);Poly 2,2(0.29) 1.9382719567087807 13.84835159778595 1.5889767408370972 2.8712503910064697 0.45581186336916 1.929691195487976 104.8034436233613 217.5538135194958 70.35453407318661 138.81289449824195 184.75640398315144 548.7390245882772 UP 0.7142857142857143 0.2857142857142857 0.0 GO:0034622 7 cellular protein-containing complex assembly 125 146 4 4 3 3 3 3 56 143 2345 0.55899 0.6678 1.0 2.05 25247;316273;84488 nsg1;mcm3;fgf13 NSG1_32675;MCM3_9207;FGF13_32529 218.44166666666663 216.472 209.76 9.815850056583747 220.96749314837692 10.999674771864198 143.27633333333333 133.518 130.074 19.958943968390177 136.3653317421094 13.824634808781077 480.24366666666674 483.266 342.576 136.18165576293012 536.6761830281928 115.43147418885152 216.472;229.093;209.76 166.237;133.518;130.074 342.576;614.889;483.266 1 2 1 25247 NSG1_32675 216.472 216.472 166.237 166.237 342.576 342.576 216.472 166.237 342.576 2 316273;84488 MCM3_9207;FGF13_32529 219.42649999999998 219.42649999999998 13.670495400679757 131.796 131.796 2.4352757544071686 549.0775 549.0775 93.07151586011662 229.093;209.76 133.518;130.074 614.889;483.266 0 Exp 2,3(1) 2.196151036773022 6.95325231552124 1.6639630794525146 3.437419891357422 0.9742029532037313 1.8518693447113037 207.33398666857926 229.54934666475407 120.69066205446767 165.862004612199 326.13961606436953 634.3477172689638 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0045944 9 positive regulation of transcription by RNA polymerase II 241 260 10 10 8 8 7 7 52 253 2235 0.75027 0.39724 0.66171 2.69 360243;78968;291773;362282;24494;24408;304729 top2a;srebf1;taf4b;pck1;il1b;grin1;gli2 TOP2A_10059;SREBF1_32750;RGD1562997_32695;PCK1_9439;IL1B_8892;GRIN1_32381;GLI2_8713 232.4204285714286 227.854 153.991 57.67112740027744 228.71781921085375 63.018240608881456 152.63899999999998 148.568 108.442 51.409120867150946 153.42345546501824 55.96282510114336 550.4947142857143 506.507 258.668 235.2868024048623 519.3109226909645 241.03234942022365 203.468;177.986;279.902;227.854;153.991;310.025;273.717 108.442;117.256;166.045;148.568;109.464;254.954;163.744 572.253;348.781;888.462;506.507;258.668;447.21;831.582 3 4 3 362282;24494;24408 PCK1_9439;IL1B_8892;GRIN1_32381 230.62333333333333 227.854 78.0538544489209 170.99533333333338 148.568 75.29325325242172 404.12833333333333 447.21 129.41431521409586 227.854;153.991;310.025 148.568;109.464;254.954 506.507;258.668;447.21 4 360243;78968;291773;304729 TOP2A_10059;SREBF1_32750;RGD1562997_32695;GLI2_8713 233.76824999999997 238.59249999999997 50.839584579833144 138.87175 140.5 30.27774027648035 660.2695 701.9175 249.12632646711597 203.468;177.986;279.902;273.717 108.442;117.256;166.045;163.744 572.253;348.781;888.462;831.582 0 Exp 2,4(0.58);Linear,3(0.43) 2.029328422721616 14.45710563659668 1.5889767408370972 2.8712503910064697 0.42977757163084623 2.0807507038116455 189.69705951106852 275.14379763178863 114.55459029821606 190.7234097017839 376.19181182283353 724.797616748595 CONFLICT 0.42857142857142855 0.5714285714285714 0.0 GO:0034613 5 cellular protein localization 184 195 7 7 7 5 5 5 54 190 2298 0.70464 0.47604 0.80238 2.56 366669;313506;25247;24408;84488 syne2;stil;nsg1;grin1;fgf13 SYNE2_9977;STIL_33274;NSG1_32675;GRIN1_32381;FGF13_32529 264.93 276.757 209.76 49.3629265086664 266.3147994177857 50.56790579639391 178.67739999999998 166.237 130.074 46.172509058962824 176.3341902995586 48.77741542301909 683.5706 483.266 342.576 389.16529223814416 713.2000570945629 391.66900774757323 276.757;311.636;216.472;310.025;209.76 164.88;177.242;166.237;254.954;130.074 858.911;1285.89;342.576;447.21;483.266 2 3 2 25247;24408 NSG1_32675;GRIN1_32381 263.2485 263.2485 66.15196070034504 210.59550000000002 210.59550000000002 62.73239230652676 394.89300000000003 394.89300000000003 73.98741094267318 216.472;310.025 166.237;254.954 342.576;447.21 3 366669;313506;84488 SYNE2_9977;STIL_33274;FGF13_32529 266.051 276.757 51.77493284399326 157.39866666666668 164.88 24.45777621398411 876.0223333333333 858.911 401.58550725883197 276.757;311.636;209.76 164.88;177.242;130.074 858.911;1285.89;483.266 0 Exp 2,3(0.6);Linear,2(0.4) 1.9916304273405296 10.401364088058472 1.6343638896942139 3.437419891357422 0.7665868120889756 1.748702883720398 221.66148717725187 308.19851282274817 138.20541137255424 219.14938862744572 342.45218121220006 1024.6890187878 DOWN 0.4 0.6 0.0 GO:0048661 7 positive regulation of smooth muscle cell proliferation 52 55 4 4 3 3 2 2 57 53 2435 0.86688 0.36608 0.36608 3.64 24451;170924 hmox1;abcc4 HMOX1_8815;ABCC4_32768 152.9648 152.9648 61.2776 129.66528173601444 142.96492124645894 128.89177684208155 96.06519999999999 96.06519999999999 39.7754 79.60579858326902 89.92594419263456 79.1309183843045 379.968 379.968 140.784 338.25725670264643 353.8813597733711 336.23941784890843 61.2776;244.652 39.7754;152.355 140.784;619.152 2 0 2 24451;170924 HMOX1_8815;ABCC4_32768 152.9648 152.9648 129.66528173601444 96.06519999999999 96.06519999999999 79.60579858326902 379.968 379.968 338.25725670264643 61.2776;244.652 39.7754;152.355 140.784;619.152 0 0 Linear,1(0.5);Poly 2,1(0.5) 1.5667336130356029 3.1338802576065063 1.5415009260177612 1.5923793315887451 0.03597646559520212 1.5669401288032532 -26.742111999999963 332.67171199999996 -14.262807999999993 206.39320800000002 -88.83264000000003 848.76864 UP 1.0 0.0 0.0 GO:0043065 8 positive regulation of apoptotic process 196 210 9 9 8 7 6 6 53 204 2284 0.79096 0.35866 0.62818 2.86 360243;24494;24451;24408;502902;29650 top2a;il1b;hmox1;grin1;clec7a;adam10 TOP2A_10059;IL1B_8892;HMOX1_8815;GRIN1_32381;CLEC7A_32927;ADAM10_7983 243.0862666666667 256.74649999999997 61.2776 127.54432829893554 246.92177194595916 142.55069051837413 171.7119 144.2135 39.7754 109.67493415498365 186.89454940994548 125.45911064226686 546.945 467.97749999999996 140.784 434.99004723418676 417.44851086514205 278.34036510113674 203.468;153.991;61.2776;310.025;412.985;316.771 108.442;109.464;39.7754;254.954;338.673;178.963 572.253;258.668;140.784;447.21;488.745;1374.01 4 2 4 24494;24451;24408;502902 IL1B_8892;HMOX1_8815;GRIN1_32381;CLEC7A_32927 234.56965 232.00799999999998 157.10781901640036 185.7166 182.209 135.77281358200298 333.85175000000004 352.93899999999996 163.06416333532619 153.991;61.2776;310.025;412.985 109.464;39.7754;254.954;338.673 258.668;140.784;447.21;488.745 2 360243;29650 TOP2A_10059;ADAM10_7983 260.1195 260.1195 80.11731962877924 143.7025 143.7025 49.865877316056626 973.1315 973.1315 566.9278115637828 203.468;316.771 108.442;178.963 572.253;1374.01 0 Exp 2,2(0.34);Linear,2(0.34);Poly 2,2(0.34) 1.9944170157731609 12.204636335372925 1.5923793315887451 2.8712503910064697 0.46233088116243565 1.9988325238227844 141.02954885331843 345.14298448001495 83.95367542400274 259.47012457599726 198.88047142178243 895.0095285782174 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0033092 11 positive regulation of immature T cell proliferation in thymus 1 1 1 1 1 1 1 1 58 0 2488 1.0 0.023165 0.023165 100.0 24494 il1b IL1B_8892 153.991 153.991 153.991 153.991 109.464 109.464 109.464 109.464 258.668 258.668 258.668 258.668 0.0 153.991 0.0 153.991 153.991 109.464 258.668 1 0 1 24494 IL1B_8892 153.991 153.991 109.464 109.464 258.668 258.668 153.991 109.464 258.668 0 0 Linear,1(1) 2.8712503910064697 2.8712503910064697 2.8712503910064697 2.8712503910064697 0.0 2.8712503910064697 153.991 153.991 109.464 109.464 258.668 258.668 UP 1.0 0.0 0.0 GO:0044283 4 small molecule biosynthetic process 144 161 7 7 6 6 6 6 53 155 2333 0.92461 0.16574 0.26871 3.73 29483;362282;24494;24450;25315;50549 slc1a3;pck1;il1b;hmgcs2;ephx1;cyp4a1 SLC1A3_32817;PCK1_9439;IL1B_8892;HMGCS2_8812;EPHX1_8567;CYP4A1_33111 223.8084 248.65500000000003 12.5094 127.28268555306337 248.28101480181545 113.84386400342169 134.95316666666665 155.351 3.282 71.71168767339586 149.75529984871406 57.33459778318742 1096.8682666666666 650.845 61.3966 1446.4587372861026 1366.4335852586987 1629.5937663111774 303.435;227.854;153.991;269.456;12.5094;375.605 189.179;148.568;109.464;162.134;3.282;197.092 992.735;506.507;258.668;795.183;61.3966;3966.72 6 0 6 29483;362282;24494;24450;25315;50549 SLC1A3_32817;PCK1_9439;IL1B_8892;HMGCS2_8812;EPHX1_8567;CYP4A1_33111 223.8084 248.65500000000003 127.28268555306337 134.95316666666665 155.351 71.71168767339586 1096.8682666666666 650.845 1446.4587372861026 303.435;227.854;153.991;269.456;12.5094;375.605 189.179;148.568;109.464;162.134;3.282;197.092 992.735;506.507;258.668;795.183;61.3966;3966.72 0 0 Exp 2,2(0.34);Hill,1(0.17);Linear,3(0.5) 2.010232632283851 12.300841689109802 1.5810112953186035 2.8712503910064697 0.4625119815440235 2.0047483444213867 121.96103998593244 325.6557600140676 77.57186582473975 192.3344675085936 -60.53977451152946 2254.2763078448625 UP 1.0 0.0 0.0 GO:0070935 8 3'-UTR-mediated mRNA stabilization 5 5 1 1 1 1 1 1 58 4 2484 0.99496 0.11066 0.11066 20.0 681410 loc681410 LOC681410_33126 410.591 410.591 410.591 410.591 326.66 326.66 326.66 326.66 495.344 495.344 495.344 495.344 0.0 410.591 0.0 410.591 410.591 326.66 495.344 1 0 1 681410 LOC681410_33126 410.591 410.591 326.66 326.66 495.344 495.344 410.591 326.66 495.344 0 0 Poly 2,1(1) 1.7326574325561523 1.7326574325561523 1.7326574325561523 1.7326574325561523 0.0 1.7326574325561523 410.591 410.591 326.66 326.66 495.344 495.344 UP 1.0 0.0 0.0 GO:0009966 5 regulation of signal transduction 594 626 22 20 17 12 10 10 49 616 1872 0.10757 0.94203 0.21998 1.6 29142;365377;338475;24494;24451;24408;304729;25311;24232;29650 vnn1;trim72;nrep;il1b;hmox1;grin1;gli2;dcc;c3;adam10 VNN1_10157;TRIM72_33144;NREP_9364;IL1B_8892;HMOX1_8815;GRIN1_32381;GLI2_8713;DCC_32537;C3_8175;ADAM10_7983 204.61584 227.88350000000003 61.2776 90.22931541512808 183.9117831561262 92.60928716728607 132.81546 145.298 39.7754 68.90599962216156 122.22507207968316 73.94794894743903 475.2982 373.30949999999996 140.784 382.3127519632759 367.95773558142326 284.938124879044 233.741;82.0928;222.026;153.991;61.2776;310.025;273.717;248.198;144.319;316.771 147.819;49.3056;142.777;109.464;39.7754;254.954;163.744;183.659;57.6936;178.963 556.851;193.467;497.741;258.668;140.784;447.21;831.582;299.409;153.26;1374.01 6 4 6 29142;365377;24494;24451;24408;24232 VNN1_10157;TRIM72_33144;IL1B_8892;HMOX1_8815;GRIN1_32381;C3_8175 164.24106666666665 149.155 93.73895854208469 109.83526666666667 83.5788 82.21110322584573 291.70666666666665 226.0675 171.56370280646982 233.741;82.0928;153.991;61.2776;310.025;144.319 147.819;49.3056;109.464;39.7754;254.954;57.6936 556.851;193.467;258.668;140.784;447.21;153.26 4 338475;304729;25311;29650 NREP_9364;GLI2_8713;DCC_32537;ADAM10_7983 265.178 260.9575 40.35330500301897 167.28574999999998 171.3535 18.41796498666487 750.6855 664.6614999999999 470.0032182673504 222.026;273.717;248.198;316.771 142.777;163.744;183.659;178.963 497.741;831.582;299.409;1374.01 0 Exp 2,1(0.1);Exp 5,1(0.1);Linear,5(0.5);Poly 2,3(0.3) 1.8694785372382303 19.012460947036743 1.5347857475280762 2.8712503910064697 0.396288913262943 1.8213455080986023 148.691130907809 260.540549092191 90.10707896168046 175.52384103831955 238.33830135273138 712.2580986472685 UP 0.6 0.4 0.0 GO:0019932 6 second-messenger-mediated signaling 68 74 6 6 5 4 4 4 55 70 2418 0.9733 0.090113 0.090113 5.41 24567;24408;316137;245920 mt1;grin1;adgre1;cxcl10 MT1A_9255;GRIN1_32381;EMR1_8558;CXCL10_8408 291.47974999999997 327.0505 119.065 119.85186550453308 316.8413896153846 98.2288467018081 185.81102500000003 199.56 89.1701 70.18647175870733 196.00232890659342 57.90541292004925 2322.16275 1249.94 178.281 2976.2422458591836 2570.7503725824176 2862.290331068804 2.5 368.4145 392.753;310.025;119.065;344.076 211.395;254.954;89.1701;187.725 6610.49;447.21;178.281;2052.67 3 1 3 24567;24408;316137 MT1A_9255;GRIN1_32381;EMR1_8558 273.94766666666663 310.025 140.3654545154659 185.17303333333334 211.395 85.94631479419782 2411.9936666666667 447.21 3638.4899749099673 392.753;310.025;119.065 211.395;254.954;89.1701 6610.49;447.21;178.281 1 245920 CXCL10_8408 344.076 344.076 187.725 187.725 2052.67 2052.67 344.076 187.725 2052.67 0 Exp 2,2(0.5);Linear,2(0.5) 2.299970397808545 9.389231085777283 1.912996768951416 3.0889737606048584 0.5594853131357197 2.193630278110504 174.0249218055577 408.93457819444234 117.02828267646673 254.59376732353326 -594.5546509420001 5238.880150941999 UP 0.75 0.25 0.0 GO:1903530 5 regulation of secretion by cell 205 222 6 6 6 4 4 4 55 218 2270 0.40473 0.77054 0.81492 1.8 78968;294228;24494;24451 srebf1;rt1-s3;il1b;hmox1 SREBF1_32750;RT1-S3_9763;IL1B_8892;HMOX1_8815 153.1154 165.9885 61.2776 66.88695567677354 165.05840288211874 67.15427836792044 102.00785 113.36 39.7754 43.67857112540047 109.22270578154752 43.156770309314254 308.19975 303.72450000000003 140.784 145.18186249982017 339.69948160810105 153.1006258403194 177.986;219.207;153.991;61.2776 117.256;141.536;109.464;39.7754 348.781;484.566;258.668;140.784 2 2 2 24494;24451 IL1B_8892;HMOX1_8815 107.63430000000001 107.63430000000001 65.55827384686086 74.6197 74.6197 49.27728163139686 199.726 199.726 83.35657579339495 153.991;61.2776 109.464;39.7754 258.668;140.784 2 78968;294228 SREBF1_32750;RT1-S3_9763 198.5965 198.5965 29.147648627290792 129.39600000000002 129.39600000000002 17.168552647209175 416.6735 416.6735 96.01449428341554 177.986;219.207 117.256;141.536 348.781;484.566 0 Exp 2,1(0.25);Linear,2(0.5);Poly 2,1(0.25) 1.8976904778351935 7.837722182273865 1.5889767408370972 2.8712503910064697 0.6147529868370853 1.688747525215149 87.56618343676197 218.66461656323807 59.202850297107545 144.81284970289246 165.9215247501763 450.47797524982366 CONFLICT 0.5 0.5 0.0 GO:0031324 6 negative regulation of cellular metabolic process 513 545 15 15 12 9 7 7 52 538 1950 0.043517 0.98133 0.077292 1.28 311715;78968;681410;24494;24451;304729;24232 tcfl5;srebf1;loc681410;il1b;hmox1;gli2;c3 TCFL5_9994;SREBF1_32750;LOC681410_33126;IL1B_8892;HMOX1_8815;GLI2_8713;C3_8175 213.25751428571428 177.986 61.2776 114.40275646118884 196.55993288641363 104.85719991766145 149.038 117.256 39.7754 100.8016920452562 132.66044280803078 89.64757381521261 366.75514285714286 338.867 140.784 238.75576206130856 362.6744570613311 252.555294948915 270.921;177.986;410.591;153.991;61.2776;273.717;144.319 228.673;117.256;326.66;109.464;39.7754;163.744;57.6936 338.867;348.781;495.344;258.668;140.784;831.582;153.26 5 2 5 311715;681410;24494;24451;24232 TCFL5_9994;LOC681410_33126;IL1B_8892;HMOX1_8815;C3_8175 208.21992 153.991 135.55591853708196 152.4532 109.464 122.14868685327731 277.3846 258.668 146.37566133001755 270.921;410.591;153.991;61.2776;144.319 228.673;326.66;109.464;39.7754;57.6936 338.867;495.344;258.668;140.784;153.26 2 78968;304729 SREBF1_32750;GLI2_8713 225.8515 225.8515 67.69203926976942 140.5 140.5 32.8719800438003 590.1815 590.1815 341.3918610636464 177.986;273.717 117.256;163.744 348.781;831.582 0 Exp 2,2(0.29);Exp 5,1(0.15);Linear,2(0.29);Poly 2,2(0.29) 1.8960263543391596 13.553873777389526 1.5889767408370972 2.8712503910064697 0.46112447196756123 1.7326574325561523 128.5067662746681 298.00826229676045 74.36306151184561 223.7129384881544 189.88239911772175 543.6278865965639 UP 0.7142857142857143 0.2857142857142857 0.0 GO:0071396 6 cellular response to lipid 195 209 10 10 8 7 6 6 53 203 2285 0.79433 0.35438 0.62746 2.87 78968;362282;24494;24450;25315;245920 srebf1;pck1;il1b;hmgcs2;ephx1;cxcl10 SREBF1_32750;PCK1_9439;IL1B_8892;HMGCS2_8812;EPHX1_8567;CXCL10_8408 197.64540000000002 202.92000000000002 12.5094 113.2066955143555 228.64360328410515 103.61653456420888 121.40483333333334 132.912 3.282 64.66508674831157 138.20850117647058 50.381475418865186 670.5342666666667 427.644 61.3966 720.687049900209 921.3255366908635 890.968977204913 177.986;227.854;153.991;269.456;12.5094;344.076 117.256;148.568;109.464;162.134;3.282;187.725 348.781;506.507;258.668;795.183;61.3966;2052.67 4 2 4 362282;24494;24450;25315 PCK1_9439;IL1B_8892;HMGCS2_8812;EPHX1_8567 165.95260000000002 190.9225 112.89026033323987 105.862 129.01600000000002 71.93972297231437 405.43865 382.5875 317.29167737707314 227.854;153.991;269.456;12.5094 148.568;109.464;162.134;3.282 506.507;258.668;795.183;61.3966 2 78968;245920 SREBF1_32750;CXCL10_8408 261.031 261.031 117.44336528727376 152.4905 152.4905 49.829107763434735 1200.7255 1200.7255 1204.831466289165 177.986;344.076 117.256;187.725 348.781;2052.67 0 Exp 2,2(0.34);Hill,1(0.17);Linear,3(0.5) 2.1462432705863246 13.102880835533142 1.5889767408370972 2.8712503910064697 0.44536754567871584 2.1321146488189697 107.06117777091455 288.2296222290855 69.66198754264994 173.14767912401675 93.86452474750456 1247.204008585829 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0042982 5 amyloid precursor protein metabolic process 5 5 3 3 3 2 2 2 57 3 2485 0.99989 0.0050446 0.0050446 40.0 25247;29650 nsg1;adam10 NSG1_32675;ADAM10_7983 266.6215 266.6215 216.472 70.92210304622951 249.8131510989011 66.81993351491634 172.6 172.6 166.237 8.998640897379936 170.46734615384614 8.47815505549217 858.293 858.293 342.576 729.3339757463656 685.4427967032967 687.1489377264413 0.0 216.472 0.0 216.472 216.472;316.771 166.237;178.963 342.576;1374.01 1 1 1 25247 NSG1_32675 216.472 216.472 166.237 166.237 342.576 342.576 216.472 166.237 342.576 1 29650 ADAM10_7983 316.771 316.771 178.963 178.963 1374.01 1374.01 316.771 178.963 1374.01 0 Exp 2,1(0.5);Linear,1(0.5) 2.3768368886643145 5.080906510353088 1.6434866189956665 3.437419891357422 1.2685023818831709 2.540453255176544 168.32848 364.91452000000004 160.12852 185.07147999999998 -152.5123199999997 1869.0983199999996 CONFLICT 0.5 0.5 0.0 GO:0006506 7 GPI anchor biosynthetic process 4 4 1 1 1 1 1 1 58 3 2485 0.99693 0.089539 0.089539 25.0 303872 pigz PIGZ_32744 355.097 355.097 355.097 355.097 212.48 212.48 212.48 212.48 459.59 459.59 459.59 459.59000000000003 0.0 355.097 0.0 355.097 355.097 212.48 459.59 1 0 1 303872 PIGZ_32744 355.097 355.097 212.48 212.48 459.59 459.59 355.097 212.48 459.59 0 0 Poly 2,1(1) 1.8452895879745483 1.8452895879745483 1.8452895879745483 1.8452895879745483 0.0 1.8452895879745483 355.097 355.097 212.48 212.48 459.59 459.59 UP 1.0 0.0 0.0 GO:0030029 3 actin filament-based process 87 94 2 2 2 2 2 2 57 92 2396 0.62744 0.64871 1.0 2.13 366669;24503 syne2;ina SYNE2_9977;INA_32322 291.1995 291.1995 276.757 20.424779374573653 292.1616271849407 20.379407132201216 207.028 207.028 164.88 59.60627322690124 209.83580589170026 59.473861991206526 658.985 658.985 459.059 282.7380606710033 645.6663751375136 282.10997751859986 276.757;305.642 164.88;249.176 858.911;459.059 1 1 1 24503 INA_32322 305.642 305.642 249.176 249.176 459.059 459.059 305.642 249.176 459.059 1 366669 SYNE2_9977 276.757 276.757 164.88 164.88 858.911 858.911 276.757 164.88 858.911 0 Exp 2,1(0.5);Linear,1(0.5) 1.7288025171678718 3.4578315019607544 1.7091286182403564 1.748702883720398 0.02798323148141405 1.7289157509803772 262.8922 319.5068 124.41792 289.63808 267.1300400000001 1050.8399599999998 CONFLICT 0.5 0.5 0.0 GO:0097120 6 receptor localization to synapse 5 5 2 2 2 2 2 2 57 3 2485 0.99989 0.0050446 0.0050446 40.0 25247;311024 nsg1;kif5c NSG1_32675;KIF5C_8965 236.6445 236.6445 216.472 28.5282230869715 245.73226193467335 25.469288928775168 187.273 187.273 166.237 29.749396498080337 196.74977085427133 26.559522216170773 357.4075 357.4075 342.576 20.974908450335256 364.08912801507535 18.72587724610933 0.0 216.472 0.0 216.472 216.472;256.817 166.237;208.309 342.576;372.239 2 0 2 25247;311024 NSG1_32675;KIF5C_8965 236.6445 236.6445 28.5282230869715 187.273 187.273 29.749396498080337 357.4075 357.4075 20.974908450335256 216.472;256.817 166.237;208.309 342.576;372.239 0 0 Exp 2,2(1) 2.8424576816317573 5.787893772125244 2.3504738807678223 3.437419891357422 0.7685868948715707 2.893946886062622 197.1064 276.1826 146.04244 228.50356 328.33776000000006 386.47724 UP 1.0 0.0 0.0 GO:0021775 8 smoothened signaling pathway involved in ventral spinal cord interneuron specification 1 1 1 1 1 1 1 1 58 0 2488 1.0 0.023165 0.023165 100.0 304729 gli2 GLI2_8713 273.717 273.717 273.717 273.717 163.744 163.744 163.744 163.744 831.582 831.582 831.582 831.582 0.0 273.717 0.0 273.717 273.717 163.744 831.582 0 1 0 1 304729 GLI2_8713 273.717 273.717 163.744 163.744 831.582 831.582 273.717 163.744 831.582 0 Linear,1(1) 2.1981756687164307 2.1981756687164307 2.1981756687164307 2.1981756687164307 0.0 2.1981756687164307 273.717 273.717 163.744 163.744 831.582 831.582 DOWN 0.0 1.0 0.0 GO:0021776 8 smoothened signaling pathway involved in spinal cord motor neuron cell fate specification 1 1 1 1 1 1 1 1 58 0 2488 1.0 0.023165 0.023165 100.0 304729 gli2 GLI2_8713 273.717 273.717 273.717 273.717 163.744 163.744 163.744 163.744 831.582 831.582 831.582 831.582 0.0 273.717 0.0 273.717 273.717 163.744 831.582 0 1 0 1 304729 GLI2_8713 273.717 273.717 163.744 163.744 831.582 831.582 273.717 163.744 831.582 0 Linear,1(1) 2.1981756687164307 2.1981756687164307 2.1981756687164307 2.1981756687164307 0.0 2.1981756687164307 273.717 273.717 163.744 163.744 831.582 831.582 DOWN 0.0 1.0 0.0 GO:0043270 6 positive regulation of ion transport 88 94 5 5 5 4 4 4 55 90 2398 0.93582 0.17117 0.27712 4.26 79212;24494;24408;245920 slc6a1;il1b;grin1;cxcl10 SLC6A1_32594;IL1B_8892;GRIN1_32381;CXCL10_8408 238.38425 232.00799999999998 145.445 103.38128121142954 229.85396042377013 105.36923262489746 164.21625 148.59449999999998 104.722 71.46881666095129 154.5928172187043 66.91989941057928 748.9122500000001 352.93899999999996 237.101 874.280408607511 769.072435216756 905.9719491612399 145.445;153.991;310.025;344.076 104.722;109.464;254.954;187.725 237.101;258.668;447.21;2052.67 3 1 3 79212;24494;24408 SLC6A1_32594;IL1B_8892;GRIN1_32381 203.15366666666668 153.991 92.6518750233007 156.38 109.464 85.40050789076143 314.32633333333337 258.668 115.58475471416347 145.445;153.991;310.025 104.722;109.464;254.954 237.101;258.668;447.21 1 245920 CXCL10_8408 344.076 344.076 187.725 187.725 2052.67 2052.67 344.076 187.725 2052.67 0 Exp 2,1(0.25);Linear,3(0.75) 2.284079137406684 9.260275483131409 1.9169143438339233 2.8712503910064697 0.44352210386021745 2.236055374145508 137.0705944127991 339.6979055872009 94.17680967226775 234.25569032773225 -107.88255043536094 1605.707050435361 UP 0.75 0.25 0.0 GO:0031329 6 regulation of cellular catabolic process 171 183 6 6 6 4 4 4 55 179 2309 0.58017 0.62287 1.0 2.19 78968;681410;24494;24451 srebf1;loc681410;il1b;hmox1 SREBF1_32750;LOC681410_33126;IL1B_8892;HMOX1_8815 200.9614 165.9885 61.2776 148.53756052473733 174.5296256431634 128.6020011267009 148.28885000000002 113.36 39.7754 123.91104704567978 125.93089216293473 106.19949666179984 310.89425 303.72450000000003 140.784 149.57962700487207 286.89099386612673 136.69825362677696 177.986;410.591;153.991;61.2776 117.256;326.66;109.464;39.7754 348.781;495.344;258.668;140.784 3 1 3 681410;24494;24451 LOC681410_33126;IL1B_8892;HMOX1_8815 208.61986666666667 153.991 180.9508155821723 158.63313333333335 109.464 149.62919562656663 298.26533333333333 258.668 180.56622055449162 410.591;153.991;61.2776 326.66;109.464;39.7754 495.344;258.668;140.784 1 78968 SREBF1_32750 177.986 177.986 117.256 117.256 348.781 348.781 177.986 117.256 348.781 0 Exp 2,1(0.25);Linear,1(0.25);Poly 2,2(0.5) 1.8835925382536352 7.785263895988464 1.5889767408370972 2.8712503910064697 0.6202462205967924 1.6625183820724487 55.394590685757436 346.52820931424264 26.856023895233804 269.7216761047662 164.30621553522533 457.4822844647747 UP 0.75 0.25 0.0 GO:0052548 7 regulation of endopeptidase activity 137 148 4 4 4 3 3 3 56 145 2343 0.54842 0.67698 1.0 2.03 24408;502902;24232 grin1;clec7a;c3 GRIN1_32381;CLEC7A_32927;C3_8175 289.10966666666667 310.025 144.319 135.54867489331411 307.09967597040117 136.52143878268717 217.10686666666666 254.954 57.6936 144.2624688969842 234.69068455147342 143.6037309658115 363.0716666666667 447.21 153.26 182.88518435984165 381.065496235233 177.8512351446979 310.025;412.985;144.319 254.954;338.673;57.6936 447.21;488.745;153.26 3 0 3 24408;502902;24232 GRIN1_32381;CLEC7A_32927;C3_8175 289.10966666666667 310.025 135.54867489331411 217.10686666666666 254.954 144.2624688969842 363.0716666666667 447.21 182.88518435984165 310.025;412.985;144.319 254.954;338.673;57.6936 447.21;488.745;153.26 0 0 Exp 2,1(0.34);Exp 5,1(0.34);Poly 2,1(0.34) 1.9080607546518753 5.742545962333679 1.7257766723632812 2.0998549461364746 0.1870541046217963 1.9169143438339233 135.7219013482809 442.49743198505246 53.8585151734643 380.35521815986897 156.11759824160657 570.0257350917268 UP 1.0 0.0 0.0 GO:0015672 7 monovalent inorganic cation transport 52 53 4 4 4 4 4 4 55 49 2439 0.99312 0.032708 0.032708 7.55 79212;29483;84487;84488 slc6a1;slc1a3;slc17a6;fgf13 SLC6A1_32594;SLC1A3_32817;SLC17A6_32912;FGF13_32529 257.06775 256.59749999999997 145.445 99.19352910808577 254.73885893621653 108.69191496863424 146.85625 146.762 104.722 37.074279695183236 141.14057151150132 35.12275958399329 541.30175 467.68550000000005 237.101 320.23651883920115 465.48076024961904 270.24842366226363 1.5 256.59749999999997 145.445;303.435;369.631;209.76 104.722;189.179;163.45;130.074 237.101;992.735;452.105;483.266 3 1 3 79212;29483;84487 SLC6A1_32594;SLC1A3_32817;SLC17A6_32912 272.837 303.435 115.18254577842937 152.45033333333333 163.45 43.289614370346754 560.647 452.105 389.3349583738919 145.445;303.435;369.631 104.722;189.179;163.45 237.101;992.735;452.105 1 84488 FGF13_32529 209.76 209.76 130.074 130.074 483.266 483.266 209.76 130.074 483.266 0 Exp 2,2(0.5);Hill,1(0.25);Linear,1(0.25) 1.7971598435475862 7.2102954387664795 1.6639630794525146 2.0017645359039307 0.16244097772416746 1.772283911705017 159.8580914740759 354.2774085259241 110.52345589872054 183.18904410127942 227.469961537583 855.1335384624172 UP 0.75 0.25 0.0 GO:0001798 10 positive regulation of type IIa hypersensitivity 4 5 2 2 2 2 2 2 57 3 2485 0.99989 0.0050446 0.0050446 40.0 294228;24232 rt1-s3;c3 RT1-S3_9763;C3_8175 181.76299999999998 181.76299999999998 144.319 52.953812629498216 194.4688682257702 49.81192725902831 99.6148 99.6148 57.6936 59.28552959095497 113.83991598830673 55.76796723136359 318.913 318.913 153.26 234.2687192477903 375.12401349224194 220.36895594059973 0.0 144.319 0.0 144.319 219.207;144.319 141.536;57.6936 484.566;153.26 1 1 1 24232 C3_8175 144.319 144.319 57.6936 57.6936 153.26 153.26 144.319 57.6936 153.26 1 294228 RT1-S3_9763 219.207 219.207 141.536 141.536 484.566 484.566 219.207 141.536 484.566 0 Exp 5,1(0.5);Linear,1(0.5) 1.7551954492436908 3.510892391204834 1.7257766723632812 1.7851157188415527 0.04195904215392949 1.755446195602417 108.37275999999999 255.15323999999998 17.44924800000001 181.780352 -5.766879999999901 643.5928799999999 CONFLICT 0.5 0.5 0.0 GO:0002886 7 regulation of myeloid leukocyte mediated immunity 26 28 3 3 3 3 3 3 56 25 2463 0.99649 0.025647 0.025647 10.71 294228;24451;24232 rt1-s3;hmox1;c3 RT1-S3_9763;HMOX1_8815;C3_8175 141.60119999999998 144.319 61.2776 78.99977008650087 159.78110404124396 80.63231503501974 79.66833333333334 57.6936 39.7754 54.32284608609286 94.55087024779644 57.53190598156693 259.53666666666663 153.26 140.784 194.98093057869366 314.09350274405455 206.88657755028785 0.5 102.7983 1.5 181.76299999999998 219.207;61.2776;144.319 141.536;39.7754;57.6936 484.566;140.784;153.26 2 1 2 24451;24232 HMOX1_8815;C3_8175 102.7983 102.7983 58.71913705922455 48.7345 48.7345 12.670080726656805 147.022 147.022 8.821864202083367 61.2776;144.319 39.7754;57.6936 140.784;153.26 1 294228 RT1-S3_9763 219.207 219.207 141.536 141.536 484.566 484.566 219.207 141.536 484.566 0 Exp 5,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 1.6991530529243914 5.103271722793579 1.5923793315887451 1.7851157188415527 0.09871110029941955 1.7257766723632812 52.20454449029474 230.9978555097053 18.19624610386679 141.14042056279987 38.89497286401979 480.1783604693135 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0098964 9 anterograde dendritic transport of messenger ribonucleoprotein complex 1 1 1 1 1 1 1 1 58 0 2488 1.0 0.023165 0.023165 100.0 311024 kif5c KIF5C_8965 256.817 256.817 256.817 256.817 208.309 208.309 208.309 208.309 372.239 372.239 372.239 372.239 0.0 256.817 0.0 256.817 256.817 208.309 372.239 1 0 1 311024 KIF5C_8965 256.817 256.817 208.309 208.309 372.239 372.239 256.817 208.309 372.239 0 0 Exp 2,1(1) 2.3504738807678223 2.3504738807678223 2.3504738807678223 2.3504738807678223 0.0 2.3504738807678223 256.817 256.817 208.309 208.309 372.239 372.239 UP 1.0 0.0 0.0 GO:0002720 7 positive regulation of cytokine production involved in immune response 22 25 2 2 2 2 2 2 57 23 2465 0.98109 0.11272 0.11272 8.0 294228;24494 rt1-s3;il1b RT1-S3_9763;IL1B_8892 186.599 186.599 153.991 46.114675841861924 195.96490274475906 44.171518646650604 125.5 125.5 109.464 22.67832868621497 130.10597449751458 21.722720590581996 371.61699999999996 371.61699999999996 258.668 159.7340076564789 404.0590188026799 153.00321576363416 0.5 186.599 219.207;153.991 141.536;109.464 484.566;258.668 1 1 1 24494 IL1B_8892 153.991 153.991 109.464 109.464 258.668 258.668 153.991 109.464 258.668 1 294228 RT1-S3_9763 219.207 219.207 141.536 141.536 484.566 484.566 219.207 141.536 484.566 0 Linear,2(1) 2.263959850729602 4.6563661098480225 1.7851157188415527 2.8712503910064697 0.7680131919696405 2.3281830549240112 122.68732000000001 250.51067999999998 94.06944 156.93056 150.23696 592.99704 CONFLICT 0.5 0.5 0.0 GO:0010817 4 regulation of hormone levels 159 176 4 4 4 3 3 3 56 173 2315 0.40883 0.78672 0.7955 1.7 286989;78968;24494 ugt2b7;srebf1;il1b UGT2B7_33032;SREBF1_32750;IL1B_8892 112.03855666666668 153.991 4.13867 94.21108832435611 121.29639793378298 88.98050835889235 76.03922666666666 109.464 1.39768 64.75877687691558 82.58456046597179 61.18347006715194 208.00586666666666 258.668 16.5686 171.802964159101 223.66974127835687 162.66199261263617 4.13867;177.986;153.991 1.39768;117.256;109.464 16.5686;348.781;258.668 2 1 2 286989;24494 UGT2B7_33032;IL1B_8892 79.064835 79.064835 105.96159871960432 55.430839999999996 55.430839999999996 76.41442768987542 137.6183 137.6183 171.19012746119446 4.13867;153.991 1.39768;109.464 16.5686;258.668 1 78968 SREBF1_32750 177.986 177.986 117.256 117.256 348.781 348.781 177.986 117.256 348.781 0 Exp 2,1(0.34);Hill,1(0.34);Linear,1(0.34) 2.534887790237938 8.030386567115784 1.5889767408370972 3.570159435272217 1.0048038311700735 2.8712503910064697 5.428674145426015 218.64843918790734 2.757772032601565 149.32068130073176 13.592510961194819 402.4192223721385 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0010819 8 regulation of T cell chemotaxis 4 4 2 2 2 2 2 2 57 2 2486 0.99995 0.0030725 0.0030725 50.0 245920;29650 cxcl10;adam10 CXCL10_8408;ADAM10_7983 330.4235 330.4235 316.771 19.307550660299945 340.2372257939582 13.422484292482878 183.344 183.344 178.963 6.195669616756994 186.49316189000774 4.307189429435527 1713.3400000000001 1713.3400000000001 1374.01 479.8850881200616 1957.2580790085203 333.6130082379698 0.0 316.771 0.0 316.771 344.076;316.771 187.725;178.963 2052.67;1374.01 0 2 0 2 245920;29650 CXCL10_8408;ADAM10_7983 330.4235 330.4235 19.307550660299945 183.344 183.344 6.195669616756994 1713.3400000000001 1713.3400000000001 479.8850881200616 344.076;316.771 187.725;178.963 2052.67;1374.01 0 Linear,2(1) 2.0149394393739977 4.1138328313827515 1.6434866189956665 2.470346212387085 0.5846780255762234 2.0569164156913757 303.6646 357.1824 174.75724 191.93076 1048.2532 2378.4268 DOWN 0.0 1.0 0.0 GO:1901951 9 regulation of anterograde dense core granule transport 1 1 1 1 1 1 1 1 58 0 2488 1.0 0.023165 0.023165 100.0 25595 map2 MAP2_32650 145.437 145.437 145.437 145.437 104.718 104.718 104.718 104.718 237.081 237.081 237.081 237.081 0.0 145.437 0.0 145.437 145.437 104.718 237.081 1 0 1 25595 MAP2_32650 145.437 145.437 104.718 104.718 237.081 237.081 145.437 104.718 237.081 0 0 Linear,1(1) 2.1256394386291504 2.1256394386291504 2.1256394386291504 2.1256394386291504 0.0 2.1256394386291504 145.437 145.437 104.718 104.718 237.081 237.081 UP 1.0 0.0 0.0 GO:0007600 5 sensory perception 62 65 4 4 4 4 4 4 55 61 2427 0.98397 0.061699 0.061699 6.15 29483;288280;24416;24408 slc1a3;ncam2;grm3;grin1 SLC1A3_32817;NCAM2_32618;GRM3_33234;GRIN1_32381 303.71975 306.73 286.986 12.03646369371108 302.290589653751 13.633438492415427 236.9445 248.3865 189.179 32.90762258707436 242.2283733305853 28.023035766260747 554.8245000000001 431.3515 363.86 293.954187911994 493.1769687963726 250.6232824784377 2.5 312.229 303.435;314.433;286.986;310.025 189.179;261.826;241.819;254.954 992.735;415.493;363.86;447.21 4 0 4 29483;288280;24416;24408 SLC1A3_32817;NCAM2_32618;GRM3_33234;GRIN1_32381 303.71975 306.73 12.03646369371108 236.9445 248.3865 32.90762258707436 554.8245000000001 431.3515 293.954187911994 303.435;314.433;286.986;310.025 189.179;261.826;241.819;254.954 992.735;415.493;363.86;447.21 0 0 Exp 2,4(1) 2.1249103814438057 8.990832448005676 1.6762725114822388 3.667783737182617 0.9523204448780757 1.8233880996704102 291.92401558016417 315.5154844198358 204.69502986466702 269.19397013533296 266.74939584624576 842.8996041537544 UP 1.0 0.0 0.0 GO:0007608 7 sensory perception of smell 5 6 1 1 1 1 1 1 58 5 2483 0.99255 0.1313 0.1313 16.67 288280 ncam2 NCAM2_32618 314.433 314.433 314.433 314.433 261.826 261.826 261.826 261.826 415.493 415.493 415.493 415.493 0.0 314.433 0.0 314.433 314.433 261.826 415.493 1 0 1 288280 NCAM2_32618 314.433 314.433 261.826 261.826 415.493 415.493 314.433 261.826 415.493 0 0 Exp 2,1(1) 1.729861855506897 1.729861855506897 1.729861855506897 1.729861855506897 0.0 1.729861855506897 314.433 314.433 261.826 261.826 415.493 415.493 UP 1.0 0.0 0.0 GO:0010769 7 regulation of cell morphogenesis involved in differentiation 72 76 5 5 5 4 4 4 55 72 2416 0.97043 0.097163 0.097163 5.26 25595;24408;84488;29650 map2;grin1;fgf13;adam10 MAP2_32650;GRIN1_32381;FGF13_32529;ADAM10_7983 245.49824999999998 259.8925 145.437 82.73045111031773 248.790593179635 66.36239354415248 167.17725000000002 154.51850000000002 104.718 66.13488946778892 175.726159221902 69.27158000643814 635.39175 465.238 237.081 504.2363822800936 528.612573567083 310.7612853748727 2.5 313.398 145.437;310.025;209.76;316.771 104.718;254.954;130.074;178.963 237.081;447.21;483.266;1374.01 2 2 2 25595;24408 MAP2_32650;GRIN1_32381 227.731 227.731 116.38129090193146 179.836 179.836 106.23289437834215 342.14549999999997 342.14549999999997 148.58364082394812 145.437;310.025 104.718;254.954 237.081;447.21 2 84488;29650 FGF13_32529;ADAM10_7983 263.2655 263.2655 75.66820376155377 154.51850000000002 154.51850000000002 34.56974342542905 928.638 928.638 629.8511227012301 209.76;316.771 130.074;178.963 483.266;1374.01 0 Exp 2,2(0.5);Linear,2(0.5) 1.827050456556523 7.350003480911255 1.6434866189956665 2.1256394386291504 0.22882834097411844 1.790438711643219 164.42240791188868 326.57409208811134 102.36505832156682 231.9894416784332 141.2400953655083 1129.5434046344917 CONFLICT 0.5 0.5 0.0 GO:0002252 3 immune effector process 125 137 5 5 5 3 3 3 56 134 2354 0.60707 0.62423 1.0 2.19 245920;24232;298566 cxcl10;c3;c1qa CXCL10_8408;C3_8175;C1QA_8167 252.28333333333333 268.455 144.319 100.85562386071162 266.1243169442665 92.07780651218596 135.72386666666668 161.753 57.6936 68.81263025821153 146.50133590647022 61.902952244400424 997.6223333333334 786.937 153.26 967.0733267370854 1087.6721079436259 927.3976922542215 344.076;144.319;268.455 187.725;57.6936;161.753 2052.67;153.26;786.937 2 1 2 24232;298566 C3_8175;C1QA_8167 206.387 206.387 87.7774073893732 109.7233 109.7233 73.5811073862034 470.0985 470.0985 448.07730378194793 144.319;268.455 57.6936;161.753 153.26;786.937 1 245920 CXCL10_8408 344.076 344.076 187.725 187.725 2052.67 2052.67 344.076 187.725 2052.67 0 Exp 5,1(0.34);Linear,2(0.67) 2.048866214942581 6.213552474975586 1.7257766723632812 2.470346212387085 0.37518410837417654 2.0174295902252197 138.15445102620515 366.4122156404615 57.85504508434637 213.59268824898692 -96.72415588148237 2091.9688225481495 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0035690 5 cellular response to drug 160 174 7 7 6 4 3 3 56 171 2317 0.41815 0.78001 0.79534 1.72 362282;24494;24451 pck1;il1b;hmox1 PCK1_9439;IL1B_8892;HMOX1_8815 147.70753333333334 153.991 61.2776 83.46577576619852 124.2086236728061 72.08192503118823 99.26913333333334 109.464 39.7754 55.10815668713058 84.95702827735644 49.85333723921388 301.98633333333333 258.668 140.784 186.66999406528447 240.68665086673892 142.33922467619084 227.854;153.991;61.2776 148.568;109.464;39.7754 506.507;258.668;140.784 3 0 3 362282;24494;24451 PCK1_9439;IL1B_8892;HMOX1_8815 147.70753333333334 153.991 83.46577576619852 99.26913333333334 109.464 55.10815668713058 301.98633333333333 258.668 186.66999406528447 227.854;153.991;61.2776 148.568;109.464;39.7754 506.507;258.668;140.784 0 0 Exp 2,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 2.146406837469116 6.626440525054932 1.5923793315887451 2.8712503910064697 0.6406754118632053 2.162810802459717 53.25711664413144 242.15795002253526 36.90838350152986 161.62988316513682 90.74934953982643 513.2233171268402 UP 1.0 0.0 0.0 GO:0032103 6 positive regulation of response to external stimulus 125 131 8 8 7 6 6 6 53 125 2363 0.97042 0.079679 0.12243 4.58 294228;24494;245920;502902;24232;29650 rt1-s3;il1b;cxcl10;clec7a;c3;adam10 RT1-S3_9763;IL1B_8892;CXCL10_8408;CLEC7A_32927;C3_8175;ADAM10_7983 265.2248333333334 267.98900000000003 144.319 109.37678714684694 267.37114546177617 110.72651570098041 169.00910000000002 160.2495 57.6936 95.84021567077149 176.16634262901894 99.78275497221522 801.9865 486.65549999999996 153.26 749.1778396497723 755.5348623390131 755.94566636988 219.207;153.991;344.076;412.985;144.319;316.771 141.536;109.464;187.725;338.673;57.6936;178.963 484.566;258.668;2052.67;488.745;153.26;1374.01 3 3 3 24494;502902;24232 IL1B_8892;CLEC7A_32927;C3_8175 237.09833333333336 153.991 152.39906997528993 168.6102 109.464 149.53615127092178 300.22433333333333 258.668 171.55973576668075 153.991;412.985;144.319 109.464;338.673;57.6936 258.668;488.745;153.26 3 294228;245920;29650 RT1-S3_9763;CXCL10_8408;ADAM10_7983 293.35133333333334 316.771 65.64622898791167 169.40800000000002 178.963 24.532212476659943 1303.7486666666666 1374.01 786.4095815319985 219.207;344.076;316.771 141.536;187.725;178.963 484.566;2052.67;1374.01 0 Exp 5,1(0.17);Linear,4(0.67);Poly 2,1(0.17) 2.0554451297929393 12.59583055973053 1.6434866189956665 2.8712503910064697 0.48571190696334954 1.9424853324890137 177.70517604983831 352.74449061682833 92.3209557576504 245.69724424234965 202.51937831075793 1401.453621689242 CONFLICT 0.5 0.5 0.0 GO:0032496 5 response to lipopolysaccharide 176 189 8 8 6 6 5 5 54 184 2304 0.72923 0.44809 0.62169 2.65 362282;681410;24494;24450;245920 pck1;loc681410;il1b;hmgcs2;cxcl10 PCK1_9439;LOC681410_33126;IL1B_8892;HMGCS2_8812;CXCL10_8408 281.1936 269.456 153.991 99.82643560851 283.2885376211454 106.46801134031685 186.91020000000003 162.134 109.464 83.0851502688657 180.99549303964758 78.13728191458434 821.6744000000001 506.507 258.668 713.9415571181579 1060.6089850807637 902.9936433049526 227.854;410.591;153.991;269.456;344.076 148.568;326.66;109.464;162.134;187.725 506.507;495.344;258.668;795.183;2052.67 4 1 4 362282;681410;24494;24450 PCK1_9439;LOC681410_33126;IL1B_8892;HMGCS2_8812 265.473 248.65500000000003 107.88655105866215 186.7065 155.351 95.93702605876418 513.9255 500.9255 219.59240947491767 227.854;410.591;153.991;269.456 148.568;326.66;109.464;162.134 506.507;495.344;258.668;795.183 1 245920 CXCL10_8408 344.076 344.076 187.725 187.725 2052.67 2052.67 344.076 187.725 2052.67 0 Exp 2,1(0.2);Linear,3(0.6);Poly 2,1(0.2) 2.1929627707559245 11.145143032073975 1.7326574325561523 2.8712503910064697 0.45399926068202606 2.162810802459717 193.69187117892352 368.6953288210766 114.08285478258827 259.7375452174117 195.87703335812614 1447.4717666418742 UP 0.8 0.2 0.0 GO:0051128 5 regulation of cellular component organization 515 547 18 18 18 13 13 13 46 534 1954 0.61513 0.51013 0.87346 2.38 360243;366669;313506;78968;25595;24494;24408;84488;25311;245920;502902;24232;29650 top2a;syne2;stil;srebf1;map2;il1b;grin1;fgf13;dcc;cxcl10;clec7a;c3;adam10 TOP2A_10059;SYNE2_9977;STIL_33274;SREBF1_32750;MAP2_32650;IL1B_8892;GRIN1_32381;FGF13_32529;DCC_32537;CXCL10_8408;CLEC7A_32927;C3_8175;ADAM10_7983 250.41607692307693 248.198 144.319 85.7718994809893 262.05208693145084 88.5763594548345 162.5956615384615 164.88 57.6936 73.21160256195216 173.52233878278497 79.59057988333774 681.5503076923077 483.266 153.26 563.6004200404137 699.7455774170437 605.5695907707144 203.468;276.757;311.636;177.986;145.437;153.991;310.025;209.76;248.198;344.076;412.985;144.319;316.771 108.442;164.88;177.242;117.256;104.718;109.464;254.954;130.074;183.659;187.725;338.673;57.6936;178.963 572.253;858.911;1285.89;348.781;237.081;258.668;447.21;483.266;299.409;2052.67;488.745;153.26;1374.01 5 8 5 25595;24494;24408;502902;24232 MAP2_32650;IL1B_8892;GRIN1_32381;CLEC7A_32927;C3_8175 233.3514 153.991 122.57737785904867 173.10052000000002 109.464 118.48920966126829 316.9928 258.668 144.09323826155062 145.437;153.991;310.025;412.985;144.319 104.718;109.464;254.954;338.673;57.6936 237.081;258.668;447.21;488.745;153.26 8 360243;366669;313506;78968;84488;25311;245920;29650 TOP2A_10059;SYNE2_9977;STIL_33274;SREBF1_32750;FGF13_32529;DCC_32537;CXCL10_8408;ADAM10_7983 261.0815 262.4775 60.7276644983864 156.030125 171.06099999999998 32.21331436106815 909.3987500000001 715.582 615.1496418428259 203.468;276.757;311.636;177.986;209.76;248.198;344.076;316.771 108.442;164.88;177.242;117.256;130.074;183.659;187.725;178.963 572.253;858.911;1285.89;348.781;483.266;299.409;2052.67;1374.01 0 Exp 2,4(0.31);Exp 5,1(0.08);Linear,6(0.47);Poly 2,2(0.16) 1.9322552570019824 25.503913164138794 1.5889767408370972 2.8712503910064697 0.3748248600195844 1.9169143438339233 203.78994123981587 297.042212606338 122.79738103752479 202.3939420393983 375.1736293750494 987.926986009566 DOWN 0.38461538461538464 0.6153846153846154 0.0 GO:0010942 6 positive regulation of cell death 222 238 12 12 11 8 7 7 52 231 2257 0.81951 0.31092 0.49417 2.94 360243;24494;24451;24408;502902;298566;29650 top2a;il1b;hmox1;grin1;clec7a;c1qa;adam10 TOP2A_10059;IL1B_8892;HMOX1_8815;GRIN1_32381;CLEC7A_32927;C1QA_8167;ADAM10_7983 246.71037142857145 268.455 61.2776 116.82566219927473 252.04294286334598 123.10864102987803 170.2892 161.753 39.7754 100.18979245385566 180.9152242788909 108.61416783476825 581.2295714285714 488.745 140.784 407.3184346351379 505.322641957695 293.7328255655852 203.468;153.991;61.2776;310.025;412.985;268.455;316.771 108.442;109.464;39.7754;254.954;338.673;161.753;178.963 572.253;258.668;140.784;447.21;488.745;786.937;1374.01 5 2 5 24494;24451;24408;502902;298566 IL1B_8892;HMOX1_8815;GRIN1_32381;CLEC7A_32927;C1QA_8167 241.34672 268.455 136.90067014442258 180.92388 161.753 118.07007879209701 424.4688 447.21 246.98115267505742 153.991;61.2776;310.025;412.985;268.455 109.464;39.7754;254.954;338.673;161.753 258.668;140.784;447.21;488.745;786.937 2 360243;29650 TOP2A_10059;ADAM10_7983 260.1195 260.1195 80.11731962877924 143.7025 143.7025 49.865877316056626 973.1315 973.1315 566.9278115637828 203.468;316.771 108.442;178.963 572.253;1374.01 0 Exp 2,2(0.29);Linear,3(0.43);Poly 2,2(0.29) 1.9976883846116558 14.222065925598145 1.5923793315887451 2.8712503910064697 0.4220954855784216 2.0174295902252197 160.16470972824982 333.2560331288931 96.06756307277821 244.51083692722176 279.4838523406974 882.9752905164453 UP 0.7142857142857143 0.2857142857142857 0.0 GO:0030155 5 regulation of cell adhesion 210 219 4 4 4 4 4 4 55 215 2273 0.4173 0.76097 0.81459 1.83 29142;294228;24494;29650 vnn1;rt1-s3;il1b;adam10 VNN1_10157;RT1-S3_9763;IL1B_8892;ADAM10_7983 230.9275 226.474 153.991 66.9169072482184 208.8727859025788 47.930542930742654 144.44549999999998 144.6775 109.464 28.489815964071745 135.67237014326648 21.610304404417732 668.5237500000001 520.7085 258.668 487.1700051059348 486.30547908309455 293.4327246856097 233.741;219.207;153.991;316.771 147.819;141.536;109.464;178.963 556.851;484.566;258.668;1374.01 2 2 2 29142;24494 VNN1_10157;IL1B_8892 193.866 193.866 56.391765799627166 128.6415 128.6415 27.121080592409903 407.7595 407.7595 210.84722133454832 233.741;153.991 147.819;109.464 556.851;258.668 2 294228;29650 RT1-S3_9763;ADAM10_7983 267.98900000000003 267.98900000000003 68.98816599968421 160.2495 160.2495 26.464885499468785 929.288 929.288 628.9318838856873 219.207;316.771 141.536;178.963 484.566;1374.01 0 Linear,4(1) 2.007926712143168 8.229543924331665 1.6434866189956665 2.8712503910064697 0.5550150189095682 1.8574034571647644 165.34893089674597 296.50606910325405 116.52548035520988 172.36551964479014 191.09714499618372 1145.9503550038162 CONFLICT 0.5 0.5 0.0 GO:0051955 7 regulation of amino acid transport 16 17 2 2 2 2 2 2 57 15 2473 0.99363 0.05742 0.05742 11.76 79212;24494 slc6a1;il1b SLC6A1_32594;IL1B_8892 149.71800000000002 149.71800000000002 145.445 6.042934552019437 148.54562794279428 5.811036527072162 107.09299999999999 107.09299999999999 104.722 3.353100356387069 106.44247480748075 3.224424901869356 247.8845 247.8845 237.101 15.25017194985087 244.9258587458746 14.664945562762448 0.0 145.445 0.5 149.71800000000002 145.445;153.991 104.722;109.464 237.101;258.668 2 0 2 79212;24494 SLC6A1_32594;IL1B_8892 149.71800000000002 149.71800000000002 6.042934552019437 107.09299999999999 107.09299999999999 3.353100356387069 247.8845 247.8845 15.25017194985087 145.445;153.991 104.722;109.464 237.101;258.668 0 0 Linear,2(1) 2.397408435460475 4.8730149269104 2.0017645359039307 2.8712503910064697 0.6148193442887893 2.4365074634552 141.34292 158.09308000000004 102.44583999999999 111.74015999999999 226.74884 269.02016000000003 UP 1.0 0.0 0.0 GO:1901653 6 cellular response to peptide 127 135 6 6 6 4 4 4 55 131 2357 0.79965 0.38217 0.55191 2.96 78968;362282;24450;24408 srebf1;pck1;hmgcs2;grin1 SREBF1_32750;PCK1_9439;HMGCS2_8812;GRIN1_32381 246.33025 248.65500000000003 177.986 56.58070876411846 243.97052929085302 67.5308880281234 170.728 155.351 117.256 59.21203789771129 177.59688729016784 70.89948665237713 524.42025 476.8585 348.781 191.87141541385637 457.186706235012 156.28016204906345 177.986;227.854;269.456;310.025 117.256;148.568;162.134;254.954 348.781;506.507;795.183;447.21 3 1 3 362282;24450;24408 PCK1_9439;HMGCS2_8812;GRIN1_32381 269.1116666666667 269.456 41.08658216904056 188.552 162.134 57.90447557831788 582.9666666666667 506.507 186.16085155674725 227.854;269.456;310.025 148.568;162.134;254.954 506.507;795.183;447.21 1 78968 SREBF1_32750 177.986 177.986 117.256 117.256 348.781 348.781 177.986 117.256 348.781 0 Exp 2,3(0.75);Linear,1(0.25) 1.8829280986260053 7.576780080795288 1.5889767408370972 2.162810802459717 0.23524564941643472 1.912496268749237 190.88115541116386 301.7793445888362 112.70020286024294 228.75579713975708 336.3862628944207 712.4542371055793 UP 0.75 0.25 0.0 GO:0021953 6 central nervous system neuron differentiation 21 22 2 2 2 2 2 2 57 20 2468 0.9867 0.090657 0.090657 9.09 360243;304729 top2a;gli2 TOP2A_10059;GLI2_8713 238.59249999999997 238.59249999999997 203.468 49.67354427157392 247.7235890856994 47.965690078617854 136.093 136.093 108.442 39.10441921317853 143.28125162802814 37.759948080794594 701.9175 701.9175 572.253 183.37329445832617 735.6255414170357 177.06863360898996 0.5 238.59249999999997 203.468;273.717 108.442;163.744 572.253;831.582 0 2 0 2 360243;304729 TOP2A_10059;GLI2_8713 238.59249999999997 238.59249999999997 49.67354427157392 136.093 136.093 39.10441921317853 701.9175 701.9175 183.37329445832617 203.468;273.717 108.442;163.744 572.253;831.582 0 Exp 2,1(0.5);Linear,1(0.5) 2.138657422258962 4.278926372528076 2.0807507038116455 2.1981756687164307 0.08303198896476593 2.139463186264038 169.74847999999997 307.43652 81.89703999999999 190.28895999999997 447.7750800000001 956.0599199999999 DOWN 0.0 1.0 0.0 GO:0051241 5 negative regulation of multicellular organismal process 326 344 10 10 10 6 6 6 53 338 2150 0.29674 0.82866 0.56464 1.74 25595;24494;24451;304729;84488;245920 map2;il1b;hmox1;gli2;fgf13;cxcl10 MAP2_32650;IL1B_8892;HMOX1_8815;GLI2_8713;FGF13_32529;CXCL10_8408 198.0431 181.8755 61.2776 100.60042150120442 215.63013595999718 105.59719314974966 122.5834 119.769 39.7754 51.65692241858784 129.89781502943472 54.05510900287992 667.3418333333333 370.967 140.784 722.4118925821796 808.3009891127032 795.3752120140053 145.437;153.991;61.2776;273.717;209.76;344.076 104.718;109.464;39.7754;163.744;130.074;187.725 237.081;258.668;140.784;831.582;483.266;2052.67 3 3 3 25595;24494;24451 MAP2_32650;IL1B_8892;HMOX1_8815 120.2352 145.437 51.2376002299093 84.65246666666667 104.718 38.93705771438481 212.17766666666668 237.081 62.76377436334859 145.437;153.991;61.2776 104.718;109.464;39.7754 237.081;258.668;140.784 3 304729;84488;245920 GLI2_8713;FGF13_32529;CXCL10_8408 275.851 273.717 67.18342378146563 160.51433333333333 163.744 28.960878963410885 1122.506 831.582 824.157029416118 273.717;209.76;344.076 163.744;130.074;187.725 831.582;483.266;2052.67 0 Exp 2,1(0.17);Linear,4(0.67);Poly 2,1(0.17) 2.108281108647231 12.921754121780396 1.5923793315887451 2.8712503910064697 0.4843205505991404 2.1619075536727905 117.5459978082909 278.5402021917091 81.24925347469477 163.91754652530523 89.29192982475365 1245.3917368419131 CONFLICT 0.5 0.5 0.0 GO:0008610 5 lipid biosynthetic process 109 122 4 4 3 3 3 3 56 119 2369 0.68775 0.54375 0.75946 2.46 78968;303872;24450 srebf1;pigz;hmgcs2 SREBF1_32750;PIGZ_32744;HMGCS2_8812 267.513 269.456 177.986 88.57148534940573 276.6766733179841 101.16470576394794 163.95666666666668 162.134 117.256 47.63815833272035 169.81399778289415 54.47152420575394 534.518 459.59 348.781 232.44212244986915 456.05794875074616 163.8864798189626 177.986;355.097;269.456 117.256;212.48;162.134 348.781;459.59;795.183 2 1 2 303872;24450 PIGZ_32744;HMGCS2_8812 312.2765 312.2765 60.557331847596956 187.307 187.307 35.59999800561807 627.3865 627.3865 237.30008601873718 355.097;269.456 212.48;162.134 459.59;795.183 1 78968 SREBF1_32750 177.986 177.986 117.256 117.256 348.781 348.781 177.986 117.256 348.781 0 Exp 2,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 1.7752495580902217 5.342344522476196 1.5889767408370972 1.9080781936645508 0.16904852449755003 1.8452895879745483 167.2849290183513 367.74107098164865 110.0490157339622 217.8643175993711 271.4849769438177 797.5510230561824 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0010506 7 regulation of autophagy 61 65 2 2 2 2 2 2 57 63 2425 0.81062 0.44817 0.66188 3.08 78968;24451 srebf1;hmox1 SREBF1_32750;HMOX1_8815 119.6318 119.6318 61.2776 82.52530106143205 118.5629954264658 82.51145756103925 78.5157 78.5157 39.7754 54.78705767040244 77.80613993714098 54.777867220387414 244.7825 244.7825 140.784 147.07608916645842 242.87768299555648 147.05141736433274 177.986;61.2776 117.256;39.7754 348.781;140.784 1 1 1 24451 HMOX1_8815 61.2776 61.2776 39.7754 39.7754 140.784 140.784 61.2776 39.7754 140.784 1 78968 SREBF1_32750 177.986 177.986 117.256 117.256 348.781 348.781 177.986 117.256 348.781 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.590677126410083 3.1813560724258423 1.5889767408370972 1.5923793315887451 0.002405994994092897 1.5906780362129211 5.257568000000006 234.006032 2.584711999999996 154.446688 40.94543999999999 448.61956 CONFLICT 0.5 0.5 0.0 GO:0051049 5 regulation of transport 454 483 14 14 13 11 10 10 49 473 2015 0.42115 0.70666 0.86642 2.07 78968;79212;294228;25595;24494;24451;24408;245920;502902;24232 srebf1;slc6a1;rt1-s3;map2;il1b;hmox1;grin1;cxcl10;clec7a;c3 SREBF1_32750;SLC6A1_32594;RT1-S3_9763;MAP2_32650;IL1B_8892;HMOX1_8815;GRIN1_32381;CXCL10_8408;CLEC7A_32927;C3_8175 211.47486000000004 165.9885 61.2776 109.63438260801415 223.2029562320003 111.33172341947993 145.6517 113.36 39.7754 91.53287715546678 153.18627075935984 92.42528699647588 484.8866 303.72450000000003 140.784 565.7116476899201 541.0451783930589 606.6050359639424 177.986;145.445;219.207;145.437;153.991;61.2776;310.025;344.076;412.985;144.319 117.256;104.722;141.536;104.718;109.464;39.7754;254.954;187.725;338.673;57.6936 348.781;237.101;484.566;237.081;258.668;140.784;447.21;2052.67;488.745;153.26 7 3 7 79212;25595;24494;24451;24408;502902;24232 SLC6A1_32594;MAP2_32650;IL1B_8892;HMOX1_8815;GRIN1_32381;CLEC7A_32927;C3_8175 196.21137142857145 145.445 120.95599062096528 144.28571428571428 104.722 110.14984464094702 280.40700000000004 237.101 136.08455755154583 145.445;145.437;153.991;61.2776;310.025;412.985;144.319 104.722;104.718;109.464;39.7754;254.954;338.673;57.6936 237.101;237.081;258.668;140.784;447.21;488.745;153.26 3 78968;294228;245920 SREBF1_32750;RT1-S3_9763;CXCL10_8408 247.08966666666666 219.207 86.48441680634339 148.83900000000003 141.536 35.79763046627511 962.0056666666666 484.566 946.9798876218722 177.986;219.207;344.076 117.256;141.536;187.725 348.781;484.566;2052.67 0 Exp 2,2(0.2);Exp 5,1(0.1);Linear,5(0.5);Poly 2,2(0.2) 1.9844211739227469 20.17801833152771 1.5889767408370972 2.8712503910064697 0.4036314030774383 1.959339439868927 143.52276565409554 279.4269543459045 88.91903497046484 202.38436502953516 134.25488810497166 835.5183118950284 UP 0.7 0.3 0.0 GO:0001970 8 positive regulation of activation of membrane attack complex 1 1 1 1 1 1 1 1 58 0 2488 1.0 0.023165 0.023165 100.0 24232 c3 C3_8175 144.319 144.319 144.319 144.319 57.6936 57.6936 57.6936 57.6936 153.26 153.26 153.26 153.26 0.0 144.319 0.0 144.319 144.319 57.6936 153.26 1 0 1 24232 C3_8175 144.319 144.319 57.6936 57.6936 153.26 153.26 144.319 57.6936 153.26 0 0 Exp 5,1(1) 1.7257766723632812 1.7257766723632812 1.7257766723632812 1.7257766723632812 0.0 1.7257766723632812 144.319 144.319 57.6936 57.6936 153.26 153.26 UP 1.0 0.0 0.0 GO:0001701 7 in utero embryonic development 63 65 4 4 4 3 3 3 56 62 2426 0.9383 0.18938 0.18938 4.62 313506;304729;29650 stil;gli2;adam10 STIL_33274;GLI2_8713;ADAM10_7983 300.708 311.636 273.717 23.515476116804372 295.1998979572973 23.728097834335614 173.31633333333332 177.242 163.744 8.334424655207421 171.38049181994637 8.431880366701211 1163.8273333333334 1285.89 831.582 291.0867649710884 1091.6460665495886 288.08100642780306 311.636;273.717;316.771 177.242;163.744;178.963 1285.89;831.582;1374.01 0 3 0 3 313506;304729;29650 STIL_33274;GLI2_8713;ADAM10_7983 300.708 311.636 23.515476116804372 173.31633333333332 177.242 8.334424655207421 1163.8273333333334 1285.89 291.0867649710884 311.636;273.717;316.771 177.242;163.744;178.963 1285.89;831.582;1374.01 0 Linear,3(1) 1.8074201056744998 5.476026177406311 1.6343638896942139 2.1981756687164307 0.32291559481135546 1.6434866189956665 274.0977337263279 327.3182662736722 163.8850439896127 182.74762267705393 834.4316499906874 1493.2230166759794 DOWN 0.0 1.0 0.0 GO:0071398 6 cellular response to fatty acid 37 38 3 3 3 3 3 3 56 35 2453 0.98934 0.056163 0.056163 7.89 78968;24494;24450 srebf1;il1b;hmgcs2 SREBF1_32750;IL1B_8892;HMGCS2_8812 200.47766666666666 177.986 153.991 60.92986015356795 178.61225138274338 44.50319777080784 129.618 117.256 109.464 28.42791775702191 119.37856563421829 20.417181557728227 467.54400000000004 348.781 258.668 287.2987537964619 364.14554028392325 207.3775689496755 0.5 165.9885 177.986;153.991;269.456 117.256;109.464;162.134 348.781;258.668;795.183 2 1 2 24494;24450 IL1B_8892;HMGCS2_8812 211.7235 211.7235 81.64608448970486 135.79899999999998 135.79899999999998 37.243314165095626 526.9255 526.9255 379.37339470830045 153.991;269.456 109.464;162.134 258.668;795.183 1 78968 SREBF1_32750 177.986 177.986 117.256 117.256 348.781 348.781 177.986 117.256 348.781 0 Exp 2,1(0.34);Linear,2(0.67) 2.0571293092896488 6.368305325508118 1.5889767408370972 2.8712503910064697 0.6675517623934665 1.9080781936645508 131.5290391904233 269.42629414291 97.44878269974643 161.78721730025356 142.43485482922677 792.6531451707732 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0002376 2 immune system process 352 390 17 17 15 11 10 10 49 380 2108 0.71384 0.41697 0.71434 2.56 29142;294228;24584;24494;24451;316137;245920;24232;298566;29650 vnn1;rt1-s3;mylpf;il1b;hmox1;adgre1;cxcl10;c3;c1qa;adam10 VNN1_10157;RT1-S3_9763;MYLPF_32295;IL1B_8892;HMOX1_8815;EMR1_8558;CXCL10_8408;C3_8175;C1QA_8167;ADAM10_7983 221.41135999999997 226.474 61.2776 100.27048898480336 221.35694789035895 94.75703600436728 131.43671 144.6775 39.7754 55.36846242711841 131.9328521635133 52.86545516193025 820.3387 520.7085 140.784 788.4334854909097 788.1124983622806 760.1354163820932 233.741;219.207;353.211;153.991;61.2776;119.065;344.076;144.319;268.455;316.771 147.819;141.536;200.468;109.464;39.7754;89.1701;187.725;57.6936;161.753;178.963 556.851;484.566;2217.36;258.668;140.784;178.281;2052.67;153.26;786.937;1374.01 7 3 7 29142;24584;24494;24451;316137;24232;298566 VNN1_10157;MYLPF_32295;IL1B_8892;HMOX1_8815;EMR1_8558;C3_8175;C1QA_8167 190.57994285714287 153.991 99.7401378748271 115.16329999999998 109.464 58.03464063514139 613.1629999999999 258.668 747.9146795399416 233.741;353.211;153.991;61.2776;119.065;144.319;268.455 147.819;200.468;109.464;39.7754;89.1701;57.6936;161.753 556.851;2217.36;258.668;140.784;178.281;153.26;786.937 3 294228;245920;29650 RT1-S3_9763;CXCL10_8408;ADAM10_7983 293.35133333333334 316.771 65.64622898791167 169.40800000000002 178.963 24.532212476659943 1303.7486666666666 1374.01 786.4095815319985 219.207;344.076;316.771 141.536;187.725;178.963 484.566;2052.67;1374.01 0 Exp 2,1(0.1);Exp 5,1(0.1);Linear,7(0.7);Poly 2,1(0.1) 2.0146616547370244 20.726323008537292 1.5923793315887451 3.0889737606048584 0.5468895933929145 1.8574034571647644 159.26306705100265 283.5596529489974 97.11898144501484 165.75443855498517 331.6625628514677 1309.0148371485323 UP 0.7 0.3 0.0 GO:0045860 8 positive regulation of protein kinase activity 136 148 6 6 5 3 3 3 56 145 2343 0.54842 0.67698 1.0 2.03 313506;24494;84488 stil;il1b;fgf13 STIL_33274;IL1B_8892;FGF13_32529 225.129 209.76 153.991 79.93835829562691 223.76289538248616 77.13508272105598 138.92666666666665 130.074 109.464 34.74538244620915 138.17889141922495 33.570823070615674 675.9413333333333 483.266 258.668 540.0362000619342 660.4271050578762 523.3655501043332 311.636;153.991;209.76 177.242;109.464;130.074 1285.89;258.668;483.266 1 2 1 24494 IL1B_8892 153.991 153.991 109.464 109.464 258.668 258.668 153.991 109.464 258.668 2 313506;84488 STIL_33274;FGF13_32529 260.698 260.698 72.0372104401611 153.65800000000002 153.65800000000002 33.35281265500693 884.5780000000001 884.5780000000001 567.5408731430714 311.636;209.76 177.242;130.074 1285.89;483.266 0 Exp 2,1(0.34);Linear,2(0.67) 1.9839063635549632 6.169577360153198 1.6343638896942139 2.8712503910064697 0.7057274003704732 1.6639630794525146 134.67023194610854 315.5877680538915 99.60856508617269 178.24476824716066 64.8328441966487 1287.049822470018 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0050790 4 regulation of catalytic activity 528 565 14 14 11 8 7 7 52 558 1930 0.032092 0.98677 0.056855 1.24 313506;25595;24494;24408;84488;502902;24232 stil;map2;il1b;grin1;fgf13;clec7a;c3 STIL_33274;MAP2_32650;IL1B_8892;GRIN1_32381;FGF13_32529;CLEC7A_32927;C3_8175 241.16471428571427 209.76 144.319 105.16538708262392 261.0737007893515 107.94622801889894 167.5455142857143 130.074 57.6936 98.15905280471125 183.16571732549139 104.60478887801669 479.15999999999997 447.21 153.26 379.7746264049246 514.0577786720321 376.13872014297976 311.636;145.437;153.991;310.025;209.76;412.985;144.319 177.242;104.718;109.464;254.954;130.074;338.673;57.6936 1285.89;237.081;258.668;447.21;483.266;488.745;153.26 5 2 5 25595;24494;24408;502902;24232 MAP2_32650;IL1B_8892;GRIN1_32381;CLEC7A_32927;C3_8175 233.3514 153.991 122.57737785904867 173.10052000000002 109.464 118.48920966126829 316.9928 258.668 144.09323826155062 145.437;153.991;310.025;412.985;144.319 104.718;109.464;254.954;338.673;57.6936 237.081;258.668;447.21;488.745;153.26 2 313506;84488 STIL_33274;FGF13_32529 260.698 260.698 72.0372104401611 153.65800000000002 153.65800000000002 33.35281265500693 884.5780000000001 884.5780000000001 567.5408731430714 311.636;209.76 177.242;130.074 1285.89;483.266 0 Exp 2,2(0.29);Exp 5,1(0.15);Linear,3(0.43);Poly 2,1(0.15) 1.9703668903121807 14.037762761116028 1.6343638896942139 2.8712503910064697 0.43076328407239695 1.9169143438339233 163.25710527502352 319.0723232964051 94.8282703434558 240.26275822797277 197.81901959842963 760.5009804015704 UP 0.7142857142857143 0.2857142857142857 0.0 GO:0051726 5 regulation of cell cycle 252 268 6 6 4 5 3 3 56 265 2223 0.11677 0.95696 0.20145 1.12 360243;313506;24494 top2a;stil;il1b TOP2A_10059;STIL_33274;IL1B_8892 223.03166666666667 203.468 153.991 80.62282118813098 225.90339981074052 86.30963217785414 131.716 109.464 108.442 39.42998387014628 135.38736976579133 40.63432965117697 705.6036666666668 572.253 258.668 526.4342879660608 725.2788533238704 563.1844715704474 203.468;311.636;153.991 108.442;177.242;109.464 572.253;1285.89;258.668 1 2 1 24494 IL1B_8892 153.991 153.991 109.464 109.464 258.668 258.668 153.991 109.464 258.668 2 360243;313506 TOP2A_10059;STIL_33274 257.552 257.552 76.4863263073863 142.84199999999998 142.84199999999998 48.64894654563456 929.0715 929.0715 504.61756200562445 203.468;311.636 108.442;177.242 572.253;1285.89 0 Exp 2,1(0.34);Linear,2(0.67) 2.1373712266028577 6.586364984512329 1.6343638896942139 2.8712503910064697 0.6263703856879861 2.0807507038116455 131.79835593570954 314.26497739762385 87.09677286891967 176.33522713108027 109.88719004567247 1301.3201432876608 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0000122 9 negative regulation of transcription by RNA polymerase II 174 180 6 6 5 5 4 4 55 176 2312 0.59436 0.60947 1.0 2.22 311715;78968;24494;304729 tcfl5;srebf1;il1b;gli2 TCFL5_9994;SREBF1_32750;IL1B_8892;GLI2_8713 219.15374999999997 224.4535 153.991 62.17706986435331 214.14984693348686 62.47055978217107 154.78425 140.5 109.464 54.778703601399755 147.5675528937518 50.09692521270001 444.47450000000003 343.824 258.668 261.20647133190755 455.8505017564065 272.7528469393682 270.921;177.986;153.991;273.717 228.673;117.256;109.464;163.744 338.867;348.781;258.668;831.582 2 2 2 311715;24494 TCFL5_9994;IL1B_8892 212.45600000000002 212.45600000000002 82.6819959241429 169.0685 169.0685 84.29349227846713 298.76750000000004 298.76750000000004 56.70925674437989 270.921;153.991 228.673;109.464 338.867;258.668 2 78968;304729 SREBF1_32750;GLI2_8713 225.8515 225.8515 67.69203926976942 140.5 140.5 32.8719800438003 590.1815 590.1815 341.3918610636464 177.986;273.717 117.256;163.744 348.781;831.582 0 Exp 2,2(0.5);Linear,2(0.5) 2.0739185151422403 8.503060340881348 1.5889767408370972 2.8712503910064697 0.5562238195217594 2.0214166045188904 158.2202215329338 280.0872784670662 101.10112047062829 208.46737952937167 188.49215809473057 700.4568419052695 CONFLICT 0.5 0.5 0.0 GO:0010628 7 positive regulation of gene expression 455 488 16 16 14 12 11 11 48 477 2011 0.5392 0.59394 1.0 2.25 360243;78968;294228;291773;362282;681410;24494;24408;304729;502902;24232 top2a;srebf1;rt1-s3;taf4b;pck1;loc681410;il1b;grin1;gli2;clec7a;c3 TOP2A_10059;SREBF1_32750;RT1-S3_9763;RGD1562997_32695;PCK1_9439;LOC681410_33126;IL1B_8892;GRIN1_32381;GLI2_8713;CLEC7A_32927;C3_8175 255.82227272727275 227.854 144.319 92.85279618524237 254.92454002987776 95.84754601748115 175.7305090909091 148.568 57.6936 91.66343530771097 177.79454962863215 94.67188447164742 497.7616363636364 488.745 153.26 216.9256475934888 473.23691897237353 201.18060862446237 203.468;177.986;219.207;279.902;227.854;410.591;153.991;310.025;273.717;412.985;144.319 108.442;117.256;141.536;166.045;148.568;326.66;109.464;254.954;163.744;338.673;57.6936 572.253;348.781;484.566;888.462;506.507;495.344;258.668;447.21;831.582;488.745;153.26 6 5 6 362282;681410;24494;24408;502902;24232 PCK1_9439;LOC681410_33126;IL1B_8892;GRIN1_32381;CLEC7A_32927;C3_8175 276.6275 268.9395 120.48160419873243 206.0021 201.76100000000002 117.61792110006029 391.6223333333333 467.97749999999996 148.97847397616437 227.854;410.591;153.991;310.025;412.985;144.319 148.568;326.66;109.464;254.954;338.673;57.6936 506.507;495.344;258.668;447.21;488.745;153.26 5 360243;78968;294228;291773;304729 TOP2A_10059;SREBF1_32750;RT1-S3_9763;RGD1562997_32695;GLI2_8713 230.856 219.207 44.5073423212395 139.4046 141.536 26.248348763303245 625.1288 572.253 229.6133464907913 203.468;177.986;219.207;279.902;273.717 108.442;117.256;141.536;166.045;163.744 572.253;348.781;484.566;888.462;831.582 0 Exp 2,4(0.37);Exp 5,1(0.1);Linear,4(0.37);Poly 2,2(0.19) 1.9543473663612276 21.80051040649414 1.5889767408370972 2.8712503910064697 0.3656912429723546 1.9169143438339233 200.9497767330624 310.694768721483 121.56088045954931 229.90013772226888 369.56677075217897 625.9565019750936 CONFLICT 0.5454545454545454 0.45454545454545453 0.0 GO:0048545 5 response to steroid hormone 158 177 9 9 8 7 7 7 52 170 2318 0.95138 0.11129 0.1861 3.95 78968;362282;25595;24494;24450;25315;24232 srebf1;pck1;map2;il1b;hmgcs2;ephx1;c3 SREBF1_32750;PCK1_9439;MAP2_32650;IL1B_8892;HMGCS2_8812;EPHX1_8567;C3_8175 161.65034285714287 153.991 12.5094 80.76382433422482 163.31317746689447 54.888509629187254 100.44508571428571 109.464 3.282 54.42410194008501 99.86743566851771 41.83372296821821 337.26808571428575 258.668 61.3966 246.52244789129875 301.79744064502347 189.20076329129876 177.986;227.854;145.437;153.991;269.456;12.5094;144.319 117.256;148.568;104.718;109.464;162.134;3.282;57.6936 348.781;506.507;237.081;258.668;795.183;61.3966;153.26 6 1 6 362282;25595;24494;24450;25315;24232 PCK1_9439;MAP2_32650;IL1B_8892;HMGCS2_8812;EPHX1_8567;C3_8175 158.92773333333335 149.714 88.11973969155078 97.64326666666666 107.09100000000001 59.06299899756756 335.34926666666667 247.8745 269.9945427194162 227.854;145.437;153.991;269.456;12.5094;144.319 148.568;104.718;109.464;162.134;3.282;57.6936 506.507;237.081;258.668;795.183;61.3966;153.26 1 78968 SREBF1_32750 177.986 177.986 117.256 117.256 348.781 348.781 177.986 117.256 348.781 0 Exp 2,2(0.29);Exp 5,1(0.15);Hill,1(0.15);Linear,3(0.43) 2.0362314922793643 14.483950734138489 1.5889767408370972 2.8712503910064697 0.41448470457580666 2.1014184951782227 101.81966450386051 221.48102121042524 60.12714677706775 140.7630246515037 154.6417005940141 519.8944708345574 UP 0.8571428571428571 0.14285714285714285 0.0 GO:0019835 3 cytolysis 7 7 1 1 1 1 1 1 58 6 2482 0.98972 0.15147 0.15147 14.29 25211 lyz2 LYZ2_32611 214.715 214.715 214.715 214.715 139.536 139.536 139.536 139.536 464.331 464.331 464.331 464.331 0.0 214.715 0.0 214.715 214.715 139.536 464.331 1 0 1 25211 LYZ2_32611 214.715 214.715 139.536 139.536 464.331 464.331 214.715 139.536 464.331 0 0 Linear,1(1) 1.5622447729110718 1.5622447729110718 1.5622447729110718 1.5622447729110718 0.0 1.5622447729110718 214.715 214.715 139.536 139.536 464.331 464.331 UP 1.0 0.0 0.0 GO:0046486 5 glycerolipid metabolic process 62 68 3 3 3 2 2 2 57 66 2422 0.79265 0.47168 0.67051 2.94 303872;25086 pigz;cyp2e1 PIGZ_32744;CYP2E1_8421 356.2365 356.2365 355.097 1.6114963543286953 355.99580727650726 1.5751363514786747 202.1245 202.1245 191.769 14.644888545153865 204.31185717255718 14.31445764600651 1535.135 1535.135 459.59 1521.0503259425705 1307.9512744282745 1486.731046195209 355.097;357.376 212.48;191.769 459.59;2610.68 2 0 2 303872;25086 PIGZ_32744;CYP2E1_8421 356.2365 356.2365 1.6114963543286953 202.1245 202.1245 14.644888545153865 1535.135 1535.135 1521.0503259425705 355.097;357.376 212.48;191.769 459.59;2610.68 0 0 Linear,1(0.5);Poly 2,1(0.5) 1.8270116612122025 3.6542043685913086 1.8089147806167603 1.8452895879745483 0.02572087294704628 1.8271021842956543 354.00307999999995 358.46992 181.82772000000003 222.42128 -572.9331999999999 3643.2031999999995 UP 1.0 0.0 0.0 GO:0000226 5 microtubule cytoskeleton organization 73 80 6 6 5 5 4 4 55 76 2412 0.96413 0.11202 0.11202 5.0 246118;313506;25595;84488 tubb3;stil;map2;fgf13 TUBB3_32820;STIL_33274;MAP2_32650;FGF13_32529 237.2765 246.0165 145.437 74.71205120326991 261.9091204291967 53.74313597453091 162.5605 153.65800000000002 104.718 58.70609902159519 187.0499872935197 56.714177273633176 590.07425 418.663 237.081 474.6488249097959 599.9344312202927 439.5366451992268 3.0 311.636 282.273;311.636;145.437;209.76 238.208;177.242;104.718;130.074 354.06;1285.89;237.081;483.266 2 2 2 246118;25595 TUBB3_32820;MAP2_32650 213.85500000000002 213.85500000000002 96.75766351044244 171.463 171.463 94.39168422059228 295.5705 295.5705 82.7166441564213 282.273;145.437 238.208;104.718 354.06;237.081 2 313506;84488 STIL_33274;FGF13_32529 260.698 260.698 72.0372104401611 153.65800000000002 153.65800000000002 33.35281265500693 884.5780000000001 884.5780000000001 567.5408731430714 311.636;209.76 177.242;130.074 1285.89;483.266 0 Exp 2,2(0.5);Linear,2(0.5) 1.9585531001450083 7.969385862350464 1.6343638896942139 2.545419454574585 0.43191199749565556 1.8948012590408325 164.05868982079568 310.4943101792044 105.02852295883676 220.09247704116322 124.91840158840012 1055.2300984116 CONFLICT 0.5 0.5 0.0 GO:0060134 7 prepulse inhibition 4 4 2 2 2 2 2 2 57 2 2486 0.99995 0.0030725 0.0030725 50.0 24408;80841 grin1;fabp7 GRIN1_32381;FABP7_8592 269.01149999999996 269.01149999999996 227.998 58.00184794038909 273.5231422000767 57.64984417860081 224.937 224.937 194.92 42.45044850175302 228.238985051744 42.19282364853179 360.815 360.815 274.42 122.18098072122359 370.3187811422001 121.4394842627481 0.0 227.998 0.0 227.998 310.025;227.998 254.954;194.92 447.21;274.42 2 0 2 24408;80841 GRIN1_32381;FABP7_8592 269.01149999999996 269.01149999999996 58.00184794038909 224.937 224.937 42.45044850175302 360.815 360.815 122.18098072122359 310.025;227.998 254.954;194.92 447.21;274.42 0 0 Exp 2,2(1) 3.1825503898486085 7.200732588768005 1.9169143438339233 5.283818244934082 2.3807605800713634 3.6003662943840027 188.62503999999998 349.3979599999999 166.10368 283.77032 191.48080000000004 530.1492 UP 1.0 0.0 0.0 GO:0051251 7 positive regulation of lymphocyte activation 82 87 4 4 4 4 4 4 55 83 2405 0.9512 0.1403 0.1403 4.6 29142;294228;24494;502902 vnn1;rt1-s3;il1b;clec7a VNN1_10157;RT1-S3_9763;IL1B_8892;CLEC7A_32927 254.981 226.474 153.991 110.8980925474676 262.78596063607927 114.86353727945901 184.373 144.6775 109.464 104.2289975102898 192.32103610531803 108.83215023098678 447.2075 486.65549999999996 258.668 129.9870013770608 445.0091977320125 115.30573249899986 233.741;219.207;153.991;412.985 147.819;141.536;109.464;338.673 556.851;484.566;258.668;488.745 3 1 3 29142;24494;502902 VNN1_10157;IL1B_8892;CLEC7A_32927 266.9056666666667 233.741 132.64386282573847 198.65200000000002 147.819 122.7688349582254 434.7546666666667 488.745 156.2513758094093 233.741;153.991;412.985 147.819;109.464;338.673 556.851;258.668;488.745 1 294228 RT1-S3_9763 219.207 219.207 141.536 141.536 484.566 484.566 219.207 141.536 484.566 0 Linear,3(0.75);Poly 2,1(0.25) 2.1347825201989394 8.685912251472473 1.7851157188415527 2.8712503910064697 0.48392421314283224 2.0147730708122253 146.30086930348182 363.66113069651817 82.22858243991601 286.517417560084 319.8202386504804 574.5947613495196 UP 0.75 0.25 0.0 GO:0007026 8 negative regulation of microtubule depolymerization 9 10 2 2 2 2 2 2 57 8 2480 0.99874 0.021069 0.021069 20.0 25595;84488 map2;fgf13 MAP2_32650;FGF13_32529 177.5985 177.5985 145.437 45.48322948626225 200.62046621334466 31.760074115833646 117.39600000000002 117.39600000000002 104.718 17.929399543766014 126.47121376965579 12.51975870654435 360.1735 360.1735 237.081 174.07908292641025 448.2860375407282 121.55611283998655 0.0 145.437 0.0 145.437 145.437;209.76 104.718;130.074 237.081;483.266 1 1 1 25595 MAP2_32650 145.437 145.437 104.718 104.718 237.081 237.081 145.437 104.718 237.081 1 84488 FGF13_32529 209.76 209.76 130.074 130.074 483.266 483.266 209.76 130.074 483.266 0 Exp 2,1(0.5);Linear,1(0.5) 1.880687519527653 3.789602518081665 1.6639630794525146 2.1256394386291504 0.32645448428731527 1.8948012590408325 114.56196000000003 240.63503999999998 92.54712 142.24488000000002 118.91219999999998 601.4348 CONFLICT 0.5 0.5 0.0 GO:0097327 5 response to antineoplastic agent 75 80 5 5 5 4 4 4 55 76 2412 0.96413 0.11202 0.11202 5.0 362282;24494;24451;29650 pck1;il1b;hmox1;adam10 PCK1_9439;IL1B_8892;HMOX1_8815;ADAM10_7983 189.97340000000003 190.9225 61.2776 108.58163329882265 141.44663664611593 90.74528766445768 119.1926 129.01600000000002 39.7754 60.103111830475726 93.3723594081381 54.514249417472534 569.99225 382.5875 140.784 557.2603908972148 342.14075092478424 394.94337823289953 3.0 316.771 227.854;153.991;61.2776;316.771 148.568;109.464;39.7754;178.963 506.507;258.668;140.784;1374.01 3 1 3 362282;24494;24451 PCK1_9439;IL1B_8892;HMOX1_8815 147.70753333333334 153.991 83.46577576619852 99.26913333333334 109.464 55.10815668713058 301.98633333333333 258.668 186.66999406528447 227.854;153.991;61.2776 148.568;109.464;39.7754 506.507;258.668;140.784 1 29650 ADAM10_7983 316.771 316.771 178.963 178.963 1374.01 1374.01 316.771 178.963 1374.01 0 Exp 2,1(0.25);Linear,2(0.5);Poly 2,1(0.25) 2.0078236963177183 8.269927144050598 1.5923793315887451 2.8712503910064697 0.5945939330343734 1.9031487107276917 83.56339936715379 296.38340063284625 60.291550406133815 178.0936495938662 23.877066920729476 1116.1074330792705 UP 0.75 0.25 0.0 GO:0001822 5 kidney development 48 53 3 3 3 3 3 3 56 50 2438 0.96729 0.12269 0.12269 5.66 24450;304729;50549 hmgcs2;gli2;cyp4a1 HMGCS2_8812;GLI2_8713;CYP4A1_33111 306.25933333333336 273.717 269.456 60.092887635171714 312.745033080634 61.41332106076864 174.32333333333335 163.744 162.134 19.734669020110893 176.4888049620951 20.13155300837716 1864.495 831.582 795.183 1820.6712181964647 2045.2853962784286 1876.557496426133 1.5 324.661 269.456;273.717;375.605 162.134;163.744;197.092 795.183;831.582;3966.72 2 1 2 24450;50549 HMGCS2_8812;CYP4A1_33111 322.5305 322.5305 75.05867771617103 179.613 179.613 24.719038856719312 2380.9515 2380.9515 2242.615319484039 269.456;375.605 162.134;197.092 795.183;3966.72 1 304729 GLI2_8713 273.717 273.717 163.744 163.744 831.582 831.582 273.717 163.744 831.582 0 Linear,3(1) 1.878730614789509 5.687265157699585 1.5810112953186035 2.1981756687164307 0.3087666769630014 1.9080781936645508 238.257829422339 374.2608372443277 151.99145304991984 196.6552136167468 -195.78843514580467 3924.7784351458045 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0050778 6 positive regulation of immune response 121 142 5 5 4 4 4 4 55 138 2350 0.77002 0.41973 0.56849 2.82 294228;24494;24232;298566 rt1-s3;il1b;c3;c1qa RT1-S3_9763;IL1B_8892;C3_8175;C1QA_8167 196.493 186.599 144.319 58.375227394275136 208.61132639852053 56.178939104294415 117.61165 125.5 57.6936 45.37763846900072 127.1605305594082 41.69199264888268 420.85775 371.61699999999996 153.26 280.4679596726098 474.58749329634765 271.47201521802873 219.207;153.991;144.319;268.455 141.536;109.464;57.6936;161.753 484.566;258.668;153.26;786.937 3 1 3 24494;24232;298566 IL1B_8892;C3_8175;C1QA_8167 188.92166666666665 153.991 69.04744911532455 109.63686666666666 109.464 52.02991537811042 399.62166666666667 258.668 339.54025857375643 153.991;144.319;268.455 109.464;57.6936;161.753 258.668;153.26;786.937 1 294228 RT1-S3_9763 219.207 219.207 141.536 141.536 484.566 484.566 219.207 141.536 484.566 0 Exp 5,1(0.25);Linear,3(0.75) 2.055323110474399 8.399572372436523 1.7257766723632812 2.8712503910064697 0.5294148348097313 1.9012726545333862 139.28527715361034 253.70072284638965 73.14156430037932 162.08173569962068 145.99914952084242 695.7163504791577 UP 0.75 0.25 0.0 GO:1903047 4 mitotic cell cycle process 136 146 7 7 6 5 4 4 55 142 2346 0.75252 0.44101 0.57884 2.74 360243;313506;316273;500545 top2a;stil;mcm3;cdca8 TOP2A_10059;STIL_33274;MCM3_9207;CDCA8_33310 299.52375 270.3645 203.468 112.79082899590432 301.58725282582634 111.7269448358983 160.8555 155.38 108.442 50.91853340058667 163.15766578181191 48.06517530863667 736.95625 593.571 474.793 370.6235311933798 713.9315309556432 346.0779912260349 203.468;311.636;229.093;453.898 108.442;177.242;133.518;224.22 572.253;1285.89;614.889;474.793 0 4 0 4 360243;313506;316273;500545 TOP2A_10059;STIL_33274;MCM3_9207;CDCA8_33310 299.52375 270.3645 112.79082899590432 160.8555 155.38 50.91853340058667 736.95625 593.571 370.6235311933798 203.468;311.636;229.093;453.898 108.442;177.242;133.518;224.22 572.253;1285.89;614.889;474.793 0 Exp 2,2(0.5);Linear,1(0.25);Power,1(0.25) 1.880901474919043 7.554382801055908 1.6343638896942139 2.0807507038116455 0.19379391891125125 1.9196341037750244 188.98873758401376 410.0587624159863 110.95533726742497 210.755662732575 373.74518943048804 1100.1673105695122 DOWN 0.0 1.0 0.0 GO:0007610 2 behavior 142 151 7 7 6 6 5 5 54 146 2342 0.86648 0.26985 0.39503 3.31 79212;29483;24494;24408;84488 slc6a1;slc1a3;il1b;grin1;fgf13 SLC6A1_32594;SLC1A3_32817;IL1B_8892;GRIN1_32381;FGF13_32529 224.53119999999998 209.76 145.445 79.03121960466004 208.16901761132874 75.88126224226477 157.67860000000002 130.074 104.722 63.92542867122596 146.03750551701827 60.537688649132825 483.796 447.21 237.101 304.91751402059526 430.1974409661072 275.2631640978961 145.445;303.435;153.991;310.025;209.76 104.722;189.179;109.464;254.954;130.074 237.101;992.735;258.668;447.21;483.266 4 1 4 79212;29483;24494;24408 SLC6A1_32594;SLC1A3_32817;IL1B_8892;GRIN1_32381 228.22400000000002 228.71300000000002 90.75791839099573 164.57975 149.32150000000001 71.63175342623323 483.9285 352.93899999999996 352.08825139018774 145.445;303.435;153.991;310.025 104.722;189.179;109.464;254.954 237.101;992.735;258.668;447.21 1 84488 FGF13_32529 209.76 209.76 130.074 130.074 483.266 483.266 209.76 130.074 483.266 0 Exp 2,3(0.6);Linear,2(0.4) 1.9838782443104355 10.130164861679077 1.6639630794525146 2.8712503910064697 0.49505436676851405 1.9169143438339233 155.2572816827523 293.80511831724766 101.64549123212728 213.71170876787275 216.52401475892373 751.0679852410763 UP 0.8 0.2 0.0 GO:0002690 7 positive regulation of leukocyte chemotaxis 36 37 3 3 3 3 3 3 56 34 2454 0.9903 0.05257 0.05257 8.11 24494;245920;29650 il1b;cxcl10;adam10 IL1B_8892;CXCL10_8408;ADAM10_7983 271.6126666666667 316.771 153.991 102.77418502879665 267.6491789175136 111.61450286791897 158.71733333333336 178.963 109.464 42.879030939765045 156.47163318364454 46.10154643341802 1228.4493333333332 1374.01 258.668 905.8155026059851 1295.2455428976602 1039.365752083544 0.5 235.38100000000003 153.991;344.076;316.771 109.464;187.725;178.963 258.668;2052.67;1374.01 1 2 1 24494 IL1B_8892 153.991 153.991 109.464 109.464 258.668 258.668 153.991 109.464 258.668 2 245920;29650 CXCL10_8408;ADAM10_7983 330.4235 330.4235 19.307550660299945 183.344 183.344 6.195669616756994 1713.3400000000001 1713.3400000000001 479.8850881200616 344.076;316.771 187.725;178.963 2052.67;1374.01 0 Linear,3(1) 2.267418509230916 6.985083222389221 1.6434866189956665 2.8712503910064697 0.6260757179287637 2.470346212387085 155.3127280181111 387.9126053152222 110.19514202423252 207.23952464243413 203.422597772558 2253.4760688941087 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0043632 6 modification-dependent macromolecule catabolic process 69 71 2 2 2 2 2 2 57 69 2419 0.7743 0.49461 0.67957 2.82 365377;316098 trim72;exosc7 TRIM72_33144;EXOSC7_8580 97.0389 97.0389 82.0928 21.1369773245845 89.00733390695348 17.825815622463196 52.0958 52.0958 49.3056 3.9459386817335886 50.596433896948476 3.3277972681699968 283.497 283.497 193.467 127.32164702044957 235.11769734867434 107.37638450768806 82.0928;111.985 49.3056;54.886 193.467;373.527 2 0 2 365377;316098 TRIM72_33144;EXOSC7_8580 97.0389 97.0389 21.1369773245845 52.0958 52.0958 3.9459386817335886 283.497 283.497 127.32164702044957 82.0928;111.985 49.3056;54.886 193.467;373.527 0 0 Poly 2,2(1) 1.7909459889817925 3.59124493598938 1.6661137342453003 1.9251312017440796 0.18315300771415302 1.79562246799469 67.74454399999999 126.333256 46.62700799999999 57.564592000000005 107.03820000000005 459.95579999999995 UP 1.0 0.0 0.0 GO:0071345 6 cellular response to cytokine stimulus 172 189 4 4 4 3 3 3 56 186 2302 0.35116 0.8264 0.79924 1.59 362282;361680;24503 pck1;lsp1;ina PCK1_9439;LSP1_32853;INA_32322 255.0103333333333 231.535 227.854 43.88691937620302 270.899025990099 46.12485544413606 179.7486666666667 148.568 141.502 60.22954465487282 200.8947113861386 64.12862995918736 515.4903333333333 506.507 459.059 61.41772657249158 501.93499554455445 64.35138867271921 227.854;231.535;305.642 148.568;141.502;249.176 506.507;580.905;459.059 2 1 2 362282;24503 PCK1_9439;INA_32322 266.748 266.748 55.00442229493933 198.872 198.872 71.14059904161608 482.783 482.783 33.550802553738734 227.854;305.642 148.568;249.176 506.507;459.059 1 361680 LSP1_32853 231.535 231.535 141.502 141.502 580.905 580.905 231.535 141.502 580.905 0 Exp 2,3(1) 1.8567314670066994 5.603565096855164 1.7091286182403564 2.162810802459717 0.2556867403155683 1.7316256761550903 205.3476088904552 304.67305777621146 111.59252078013412 247.90481255319924 445.98963303283347 584.9910336338334 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0034641 4 cellular nitrogen compound metabolic process 478 543 18 17 14 15 13 13 46 530 1958 0.62662 0.4982 0.8727 2.39 29142;360243;78968;291773;362282;497009;316273;681410;24451;24450;316098;64564;29650 vnn1;top2a;srebf1;taf4b;pck1;naaa;mcm3;loc681410;hmox1;hmgcs2;exosc7;bbox1;adam10 VNN1_10157;TOP2A_10059;SREBF1_32750;RGD1562997_32695;PCK1_9439;NAAA_32484;MCM3_9207;LOC681410_33126;HMOX1_8815;HMGCS2_8812;EXOSC7_8580;BBOX1_8133;ADAM10_7983 240.56727692307692 229.093 61.2776 109.95798064198698 209.94340075071364 98.52270880308576 150.1034153846154 147.819 39.7754 76.64087620112656 132.71081266323526 68.9088259136662 569.9023846153846 506.507 140.784 314.92272989087843 476.04763884830635 252.01187765239735 233.741;203.468;177.986;279.902;227.854;151.002;229.093;410.591;61.2776;269.456;111.985;454.248;316.771 147.819;108.442;117.256;166.045;148.568;107.821;133.518;326.66;39.7754;162.134;54.886;259.457;178.963 556.851;572.253;348.781;888.462;506.507;250.969;614.889;495.344;140.784;795.183;373.527;491.171;1374.01 8 5 8 29142;362282;497009;681410;24451;24450;316098;64564 VNN1_10157;PCK1_9439;NAAA_32484;LOC681410_33126;HMOX1_8815;HMGCS2_8812;EXOSC7_8580;BBOX1_8133 240.01932499999998 230.7975 137.48144218720424 155.89005 148.1935 97.13120269595582 451.29200000000003 493.2575 199.49051160751617 233.741;227.854;151.002;410.591;61.2776;269.456;111.985;454.248 147.819;148.568;107.821;326.66;39.7754;162.134;54.886;259.457 556.851;506.507;250.969;495.344;140.784;795.183;373.527;491.171 5 360243;78968;291773;316273;29650 TOP2A_10059;SREBF1_32750;RGD1562997_32695;MCM3_9207;ADAM10_7983 241.44399999999996 229.093 56.51286630936376 140.8448 133.518 30.61087299800523 759.6790000000001 614.889 393.3565350385065 203.468;177.986;279.902;229.093;316.771 108.442;117.256;166.045;133.518;178.963 572.253;348.781;888.462;614.889;1374.01 0 Exp 2,4(0.31);Linear,5(0.39);Poly 2,3(0.24);Power,1(0.08) 1.8986027838074269 24.982304334640503 1.5889767408370972 2.7777180671691895 0.327407964244277 1.9080781936645508 180.7934377532096 300.3411160929443 108.44096049832976 191.76587027090105 398.7084385504546 741.0963306803145 UP 0.6153846153846154 0.38461538461538464 0.0 GO:0016046 6 detection of fungus 1 1 1 1 1 1 1 1 58 0 2488 1.0 0.023165 0.023165 100.0 502902 clec7a CLEC7A_32927 412.985 412.985 412.985 412.985 338.673 338.673 338.673 338.673 488.745 488.745 488.745 488.745 0.0 412.985 0.0 412.985 412.985 338.673 488.745 1 0 1 502902 CLEC7A_32927 412.985 412.985 338.673 338.673 488.745 488.745 412.985 338.673 488.745 0 0 Poly 2,1(1) 2.0998549461364746 2.0998549461364746 2.0998549461364746 2.0998549461364746 0.0 2.0998549461364746 412.985 412.985 338.673 338.673 488.745 488.745 UP 1.0 0.0 0.0 GO:1901342 6 regulation of vasculature development 120 124 5 5 5 5 5 5 54 119 2369 0.93557 0.15694 0.20775 4.03 24494;24451;245920;24232;29650 il1b;hmox1;cxcl10;c3;adam10 IL1B_8892;HMOX1_8815;CXCL10_8408;C3_8175;ADAM10_7983 204.08692000000002 153.991 61.2776 121.21360458435352 198.23685777594275 123.85583264172558 114.7242 109.464 39.7754 67.73703176239717 111.35035161023946 67.97778483795355 795.8783999999999 258.668 140.784 872.4195331873307 815.5505884943572 961.8781277100455 153.991;61.2776;344.076;144.319;316.771 109.464;39.7754;187.725;57.6936;178.963 258.668;140.784;2052.67;153.26;1374.01 3 2 3 24494;24451;24232 IL1B_8892;HMOX1_8815;C3_8175 119.86253333333333 144.319 50.96599558777727 68.97766666666666 57.6936 36.18871181588722 184.23733333333334 153.26 64.75998571134289 153.991;61.2776;144.319 109.464;39.7754;57.6936 258.668;140.784;153.26 2 245920;29650 CXCL10_8408;ADAM10_7983 330.4235 330.4235 19.307550660299945 183.344 183.344 6.195669616756994 1713.3400000000001 1713.3400000000001 479.8850881200616 344.076;316.771 187.725;178.963 2052.67;1374.01 0 Exp 5,1(0.2);Linear,3(0.6);Poly 2,1(0.2) 2.000438654155404 10.303239226341248 1.5923793315887451 2.8712503910064697 0.5767076450049735 1.7257766723632812 97.83851101782935 310.3353289821707 55.350073815005295 174.0983261849947 31.16896260664214 1560.5878373933579 UP 0.6 0.4 0.0 GO:0010941 5 regulation of cell death 479 511 20 20 18 14 13 13 46 498 1990 0.71517 0.40217 0.74185 2.54 29142;360243;313506;24567;24494;24451;24408;304729;25311;245920;502902;298566;29650 vnn1;top2a;stil;mt1;il1b;hmox1;grin1;gli2;dcc;cxcl10;clec7a;c1qa;adam10 VNN1_10157;TOP2A_10059;STIL_33274;MT1A_9255;IL1B_8892;HMOX1_8815;GRIN1_32381;GLI2_8713;DCC_32537;CXCL10_8408;CLEC7A_32927;C1QA_8167;ADAM10_7983 271.62258461538465 273.717 61.2776 95.63167239767573 277.8691469512688 97.93181305406702 174.12372307692308 177.242 39.7754 72.34486685543246 181.24445414676018 76.65290659248778 1208.1153076923079 572.253 140.784 1708.8737387175693 1201.215712925324 1703.6134973861003 233.741;203.468;311.636;392.753;153.991;61.2776;310.025;273.717;248.198;344.076;412.985;268.455;316.771 147.819;108.442;177.242;211.395;109.464;39.7754;254.954;163.744;183.659;187.725;338.673;161.753;178.963 556.851;572.253;1285.89;6610.49;258.668;140.784;447.21;831.582;299.409;2052.67;488.745;786.937;1374.01 7 6 7 29142;24567;24494;24451;24408;502902;298566 VNN1_10157;MT1A_9255;IL1B_8892;HMOX1_8815;GRIN1_32381;CLEC7A_32927;C1QA_8167 261.8896571428571 268.455 125.82712789043637 180.54762857142856 161.753 98.13732326167099 1327.097857142857 488.745 2338.9886557100863 233.741;392.753;153.991;61.2776;310.025;412.985;268.455 147.819;211.395;109.464;39.7754;254.954;338.673;161.753 556.851;6610.49;258.668;140.784;447.21;488.745;786.937 6 360243;313506;304729;25311;245920;29650 TOP2A_10059;STIL_33274;GLI2_8713;DCC_32537;CXCL10_8408;ADAM10_7983 282.97766666666666 292.67650000000003 51.60129462975401 166.62916666666666 178.1025 29.6441415285832 1069.3023333333333 1058.736 632.941338305744 203.468;311.636;273.717;248.198;344.076;316.771 108.442;177.242;163.744;183.659;187.725;178.963 572.253;1285.89;831.582;299.409;2052.67;1374.01 0 Exp 2,3(0.24);Linear,7(0.54);Poly 2,3(0.24) 1.997205710568067 26.30152690410614 1.5923793315887451 2.8712503910064697 0.3512016663866711 1.933887243270874 219.6366153199337 323.6085539108355 134.7966054731385 213.4508406807076 279.16096146534653 2137.069653919269 CONFLICT 0.5384615384615384 0.46153846153846156 0.0 GO:0040008 4 regulation of growth 171 186 8 8 8 5 5 5 54 181 2307 0.74132 0.43399 0.61616 2.69 24567;25595;84488;24232;29650 mt1;map2;fgf13;c3;adam10 MT1A_9255;MAP2_32650;FGF13_32529;C3_8175;ADAM10_7983 241.808 209.76 144.319 109.79798889323975 245.46144666627916 110.88377066331452 136.56872 130.074 57.6936 60.56851794201341 135.12007557984074 64.14998786866657 1771.6214 483.266 153.26 2748.0225458694476 2096.2461413125616 3086.9667641004944 392.753;145.437;209.76;144.319;316.771 211.395;104.718;130.074;57.6936;178.963 6610.49;237.081;483.266;153.26;1374.01 3 2 3 24567;25595;24232 MT1A_9255;MAP2_32650;C3_8175 227.50300000000001 145.437 143.11178971699007 124.6022 104.718 78.75637210867448 2333.6103333333335 237.081 3704.123547125599 392.753;145.437;144.319 211.395;104.718;57.6936 6610.49;237.081;153.26 2 84488;29650 FGF13_32529;ADAM10_7983 263.2655 263.2655 75.66820376155377 154.51850000000002 154.51850000000002 34.56974342542905 928.638 928.638 629.8511227012301 209.76;316.771 130.074;178.963 483.266;1374.01 0 Exp 2,2(0.4);Exp 5,1(0.2);Linear,2(0.4) 1.8055921488724693 9.071862578392029 1.6434866189956665 2.1256394386291504 0.20389216040621572 1.7257766723632812 145.565819352444 338.050180647556 83.47807322141503 189.659366778585 -637.1265647763178 4180.369364776318 UP 0.6 0.4 0.0 GO:0019752 6 carboxylic acid metabolic process 287 320 15 14 14 12 12 12 47 308 2180 0.97214 0.058689 0.074089 3.75 29142;286989;29483;362282;497009;24494;25315;171142;29740;50549;25086;24232 vnn1;ugt2b7;slc1a3;pck1;naaa;il1b;ephx1;ehhadh;eci1;cyp4a1;cyp2e1;c3 VNN1_10157;UGT2B7_33032;SLC1A3_32817;PCK1_9439;NAAA_32484;IL1B_8892;EPHX1_8567;EHHADH_8534;ECI1_8520;CYP4A1_33111;CYP2E1_8421;C3_8175 200.8683391666667 211.806 4.13867 117.52304858538426 208.32758939672843 108.0431824501925 120.20152333333334 139.2985 1.39768 67.9751344052273 125.48949066870229 60.85556190189143 866.6086 447.254 16.5686 1198.6439576659495 882.5907947568155 1205.270258964569 233.741;4.13867;303.435;227.854;151.002;153.991;12.5094;250.691;195.758;375.605;357.376;144.319 147.819;1.39768;189.179;148.568;107.821;109.464;3.282;157.555;130.778;197.092;191.769;57.6936 556.851;16.5686;992.735;506.507;250.969;258.668;61.3966;636.947;388.001;3966.72;2610.68;153.26 12 0 12 29142;286989;29483;362282;497009;24494;25315;171142;29740;50549;25086;24232 VNN1_10157;UGT2B7_33032;SLC1A3_32817;PCK1_9439;NAAA_32484;IL1B_8892;EPHX1_8567;EHHADH_8534;ECI1_8520;CYP4A1_33111;CYP2E1_8421;C3_8175 200.8683391666667 211.806 117.52304858538426 120.20152333333334 139.2985 67.9751344052273 866.6086 447.254 1198.6439576659495 233.741;4.13867;303.435;227.854;151.002;153.991;12.5094;250.691;195.758;375.605;357.376;144.319 147.819;1.39768;189.179;148.568;107.821;109.464;3.282;157.555;130.778;197.092;191.769;57.6936 556.851;16.5686;992.735;506.507;250.969;258.668;61.3966;636.947;388.001;3966.72;2610.68;153.26 0 0 Exp 2,3(0.25);Exp 5,1(0.09);Hill,2(0.17);Linear,6(0.5) 1.9928425569980202 24.71119725704193 1.5261523723602295 3.570159435272217 0.6043478891935828 1.8693029880523682 134.37341470464472 267.3632636286886 81.74097042921554 158.66207623745115 188.41193661146463 1544.8052633885354 UP 1.0 0.0 0.0 GO:0071702 5 organic substance transport 316 335 10 10 9 7 6 6 53 329 2159 0.32474 0.8082 0.69542 1.79 79212;29483;84487;25247;311024;170924 slc6a1;slc1a3;slc17a6;nsg1;kif5c;abcc4 SLC6A1_32594;SLC1A3_32817;SLC17A6_32912;NSG1_32675;KIF5C_8965;ABCC4_32768 256.0753333333333 250.7345 145.445 76.25793694735445 259.63150791215406 92.0633079126642 164.042 164.8435 104.722 35.361145105892675 157.74681811071 39.62362462801372 502.6513333333333 412.172 237.101 271.83002263963914 455.4076692238267 246.0362503073915 145.445;303.435;369.631;216.472;256.817;244.652 104.722;189.179;163.45;166.237;208.309;152.355 237.101;992.735;452.105;342.576;372.239;619.152 6 0 6 79212;29483;84487;25247;311024;170924 SLC6A1_32594;SLC1A3_32817;SLC17A6_32912;NSG1_32675;KIF5C_8965;ABCC4_32768 256.0753333333333 250.7345 76.25793694735445 164.042 164.8435 35.361145105892675 502.6513333333333 412.172 271.83002263963914 145.445;303.435;369.631;216.472;256.817;244.652 104.722;189.179;163.45;166.237;208.309;152.355 237.101;992.735;452.105;342.576;372.239;619.152 0 0 Exp 2,3(0.5);Hill,1(0.17);Linear,2(0.34) 2.0673903775521807 12.87572705745697 1.5415009260177612 3.437419891357422 0.691890410121209 1.935029923915863 195.05627544293876 317.09439122372794 135.7471910048824 192.3368089951176 285.14201493613723 720.1606517305296 UP 1.0 0.0 0.0 GO:2001234 7 negative regulation of apoptotic signaling pathway 88 93 4 4 3 3 3 3 56 90 2398 0.83338 0.36613 0.47469 3.23 29142;24494;24451 vnn1;il1b;hmox1 VNN1_10157;IL1B_8892;HMOX1_8815 149.66986666666668 153.991 61.2776 86.31286248209668 134.37965540618558 79.8136257965717 99.01946666666667 109.464 39.7754 54.77381749205848 90.30716348041237 52.18661853063404 318.7676666666667 258.668 140.784 214.44559816497355 273.98138622680415 187.09309147025957 233.741;153.991;61.2776 147.819;109.464;39.7754 556.851;258.668;140.784 3 0 3 29142;24494;24451 VNN1_10157;IL1B_8892;HMOX1_8815 149.66986666666668 153.991 86.31286248209668 99.01946666666667 109.464 54.77381749205848 318.7676666666667 258.668 214.44559816497355 233.741;153.991;61.2776 147.819;109.464;39.7754 556.851;258.668;140.784 0 0 Linear,2(0.67);Poly 2,1(0.34) 2.066340105045107 6.393320918083191 1.5923793315887451 2.8712503910064697 0.662800145696124 1.929691195487976 51.997668065077946 247.3420652682554 37.03705725044318 161.00187608289016 76.09962796559415 561.4357053677393 UP 1.0 0.0 0.0 GO:0051173 6 positive regulation of nitrogen compound metabolic process 649 698 20 20 17 13 12 12 47 686 1802 0.13823 0.91962 0.24059 1.72 360243;313506;78968;291773;362282;24494;24408;304729;84488;25311;502902;24232 top2a;stil;srebf1;taf4b;pck1;il1b;grin1;gli2;fgf13;dcc;clec7a;c3 TOP2A_10059;STIL_33274;SREBF1_32750;RGD1562997_32695;PCK1_9439;IL1B_8892;GRIN1_32381;GLI2_8713;FGF13_32529;DCC_32537;CLEC7A_32927;C3_8175 246.1534166666667 238.026 144.319 76.927104681177 252.56687390860642 84.96495835619389 162.98454999999998 156.156 57.6936 74.02274021820475 171.702266247118 82.42332970219564 547.00275 486.0055 153.26 316.51387420146807 526.8470799410363 321.2962218005178 203.468;311.636;177.986;279.902;227.854;153.991;310.025;273.717;209.76;248.198;412.985;144.319 108.442;177.242;117.256;166.045;148.568;109.464;254.954;163.744;130.074;183.659;338.673;57.6936 572.253;1285.89;348.781;888.462;506.507;258.668;447.21;831.582;483.266;299.409;488.745;153.26 5 7 5 362282;24494;24408;502902;24232 PCK1_9439;IL1B_8892;GRIN1_32381;CLEC7A_32927;C3_8175 249.8348 227.854 112.96417745551014 181.87052 148.568 113.68804051065355 370.878 447.21 156.5751477549998 227.854;153.991;310.025;412.985;144.319 148.568;109.464;254.954;338.673;57.6936 506.507;258.668;447.21;488.745;153.26 7 360243;313506;78968;291773;304729;84488;25311 TOP2A_10059;STIL_33274;SREBF1_32750;RGD1562997_32695;GLI2_8713;FGF13_32529;DCC_32537 243.52385714285714 248.198 48.19368428341558 149.49457142857142 163.744 30.320203868362224 672.8061428571428 572.253 350.7238128049993 203.468;311.636;177.986;279.902;273.717;209.76;248.198 108.442;177.242;117.256;166.045;163.744;130.074;183.659 572.253;1285.89;348.781;888.462;831.582;483.266;299.409 0 Exp 2,5(0.42);Exp 5,1(0.09);Linear,4(0.34);Poly 2,2(0.17) 1.931806638336416 23.514951467514038 1.5889767408370972 2.8712503910064697 0.3636490370291184 1.9254007935523987 202.62780976292362 289.67902357040964 121.10224198868849 204.86685801131154 367.9181669369804 726.0873330630195 CONFLICT 0.4166666666666667 0.5833333333333334 0.0 GO:0046951 5 ketone body biosynthetic process 1 1 1 1 1 1 1 1 58 0 2488 1.0 0.023165 0.023165 100.0 24450 hmgcs2 HMGCS2_8812 269.456 269.456 269.456 269.456 162.134 162.134 162.134 162.134 795.183 795.183 795.183 795.183 0.0 269.456 0.0 269.456 269.456 162.134 795.183 1 0 1 24450 HMGCS2_8812 269.456 269.456 162.134 162.134 795.183 795.183 269.456 162.134 795.183 0 0 Linear,1(1) 1.9080781936645508 1.9080781936645508 1.9080781936645508 1.9080781936645508 0.0 1.9080781936645508 269.456 269.456 162.134 162.134 795.183 795.183 UP 1.0 0.0 0.0 GO:0045321 3 leukocyte activation 139 149 6 6 5 4 3 3 56 146 2342 0.54316 0.68151 1.0 2.01 294228;298566;29650 rt1-s3;c1qa;adam10 RT1-S3_9763;C1QA_8167;ADAM10_7983 268.14433333333335 268.455 219.207 48.78274192102481 246.5588093946074 36.518614614966246 160.75066666666666 161.753 141.536 18.733621815691148 152.60275479057148 14.538570513093878 881.8376666666667 786.937 484.566 452.2524291635517 670.3771663557742 284.08036965789375 219.207;268.455;316.771 141.536;161.753;178.963 484.566;786.937;1374.01 1 2 1 298566 C1QA_8167 268.455 268.455 161.753 161.753 786.937 786.937 268.455 161.753 786.937 2 294228;29650 RT1-S3_9763;ADAM10_7983 267.98900000000003 267.98900000000003 68.98816599968421 160.2495 160.2495 26.464885499468785 929.288 929.288 628.9318838856873 219.207;316.771 141.536;178.963 484.566;1374.01 0 Linear,3(1) 1.808882307711195 5.446031928062439 1.6434866189956665 2.0174295902252197 0.18879525174661635 1.7851157188415527 212.94146414070613 323.3472025259606 139.55157793422242 181.9497553991109 370.0658656969588 1393.6094676363746 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:1904862 8 inhibitory synapse assembly 1 1 1 1 1 1 1 1 58 0 2488 1.0 0.023165 0.023165 100.0 84488 fgf13 FGF13_32529 209.76 209.76 209.76 209.76 130.074 130.074 130.074 130.074 483.266 483.266 483.266 483.266 0.0 209.76 0.0 209.76 209.76 130.074 483.266 0 1 0 1 84488 FGF13_32529 209.76 209.76 130.074 130.074 483.266 483.266 209.76 130.074 483.266 0 Exp 2,1(1) 1.6639630794525146 1.6639630794525146 1.6639630794525146 1.6639630794525146 0.0 1.6639630794525146 209.76 209.76 130.074 130.074 483.266 483.266 DOWN 0.0 1.0 0.0 GO:0033089 10 positive regulation of T cell differentiation in thymus 4 4 2 2 2 2 2 2 57 2 2486 0.99995 0.0030725 0.0030725 50.0 29142;24494 vnn1;il1b VNN1_10157;IL1B_8892 193.866 193.866 153.991 56.391765799627166 180.62086400969437 53.18988621154036 128.6415 128.6415 109.464 27.121080592409903 122.27137848391007 25.581167218102 407.7595 407.7595 258.668 210.84722133454832 358.23631021946954 198.87548388985292 0.0 153.991 0.0 153.991 233.741;153.991 147.819;109.464 556.851;258.668 2 0 2 29142;24494 VNN1_10157;IL1B_8892 193.866 193.866 56.391765799627166 128.6415 128.6415 27.121080592409903 407.7595 407.7595 210.84722133454832 233.741;153.991 147.819;109.464 556.851;258.668 0 0 Linear,2(1) 2.353853563747455 4.800941586494446 1.929691195487976 2.8712503910064697 0.6657828920396772 2.400470793247223 115.71100000000001 272.021 91.05360000000002 166.2294 115.54016000000001 699.97884 UP 1.0 0.0 0.0 GO:0051179 2 localization 693 737 22 22 20 18 16 16 43 721 1767 0.44163 0.67021 0.88463 2.17 365377;366669;313506;78968;79212;29483;84487;25247;311024;24494;24408;84488;363198;500545;29650;170924 trim72;syne2;stil;srebf1;slc6a1;slc1a3;slc17a6;nsg1;kif5c;il1b;grin1;fgf13;cenpq;cdca8;adam10;abcc4 TRIM72_33144;SYNE2_9977;STIL_33274;SREBF1_32750;SLC6A1_32594;SLC1A3_32817;SLC17A6_32912;NSG1_32675;KIF5C_8965;IL1B_8892;GRIN1_32381;FGF13_32529;CENPQ_8290;CDCA8_33310;ADAM10_7983;ABCC4_32768 241.83376875000002 250.7345 39.9715 106.67999530647226 228.9016504117841 120.50149386737709 150.17425625 164.165 12.1775 62.186690167998336 138.14615909925172 68.31043466190587 557.3941875 449.6575 177.403 375.052885677068 467.97722982257994 316.8632508419942 82.0928;276.757;311.636;177.986;145.445;303.435;369.631;216.472;256.817;153.991;310.025;209.76;39.9715;453.898;316.771;244.652 49.3056;164.88;177.242;117.256;104.722;189.179;163.45;166.237;208.309;109.464;254.954;130.074;12.1775;224.22;178.963;152.355 193.467;858.911;1285.89;348.781;237.101;992.735;452.105;342.576;372.239;258.668;447.21;483.266;177.403;474.793;1374.01;619.152 9 7 9 365377;79212;29483;84487;25247;311024;24494;24408;170924 TRIM72_33144;SLC6A1_32594;SLC1A3_32817;SLC17A6_32912;NSG1_32675;KIF5C_8965;IL1B_8892;GRIN1_32381;ABCC4_32768 231.39564444444443 244.652 91.64897769144935 155.3306222222222 163.45 61.21402137569833 435.0281111111111 372.239 246.60146612319872 82.0928;145.445;303.435;369.631;216.472;256.817;153.991;310.025;244.652 49.3056;104.722;189.179;163.45;166.237;208.309;109.464;254.954;152.355 193.467;237.101;992.735;452.105;342.576;372.239;258.668;447.21;619.152 7 366669;313506;78968;84488;363198;500545;29650 SYNE2_9977;STIL_33274;SREBF1_32750;FGF13_32529;CENPQ_8290;CDCA8_33310;ADAM10_7983 255.2542142857143 276.757 129.91772500569263 143.54464285714286 164.88 67.68008052639654 714.722 483.266 468.2318419878484 276.757;311.636;177.986;209.76;39.9715;453.898;316.771 164.88;177.242;117.256;130.074;12.1775;224.22;178.963 858.911;1285.89;348.781;483.266;177.403;474.793;1374.01 0 Exp 2,6(0.38);Exp 4,1(0.07);Hill,1(0.07);Linear,6(0.38);Poly 2,1(0.07);Power,1(0.07) 1.9180768600917038 31.49607491493225 1.5415009260177612 3.437419891357422 0.5163392922108492 1.8084990978240967 189.56057104982858 294.10696645017146 119.70277806768081 180.64573443231922 373.6182735182366 741.1701014817633 CONFLICT 0.5625 0.4375 0.0 GO:0030903 6 notochord development 1 1 1 1 1 1 1 1 58 0 2488 1.0 0.023165 0.023165 100.0 313506 stil STIL_33274 311.636 311.636 311.636 311.636 177.242 177.242 177.242 177.242 1285.89 1285.89 1285.89 1285.89 0.0 311.636 0.0 311.636 311.636 177.242 1285.89 0 1 0 1 313506 STIL_33274 311.636 311.636 177.242 177.242 1285.89 1285.89 311.636 177.242 1285.89 0 Linear,1(1) 1.6343638896942139 1.6343638896942139 1.6343638896942139 1.6343638896942139 0.0 1.6343638896942139 311.636 311.636 177.242 177.242 1285.89 1285.89 DOWN 0.0 1.0 0.0 GO:0032764 8 negative regulation of mast cell cytokine production 1 1 1 1 1 1 1 1 58 0 2488 1.0 0.023165 0.023165 100.0 24451 hmox1 HMOX1_8815 61.2776 61.2776 61.2776 61.2776 39.7754 39.7754 39.7754 39.7754 140.784 140.784 140.784 140.784 0.0 61.2776 0.0 61.2776 61.2776 39.7754 140.784 1 0 1 24451 HMOX1_8815 61.2776 61.2776 39.7754 39.7754 140.784 140.784 61.2776 39.7754 140.784 0 0 Poly 2,1(1) 1.5923793315887451 1.5923793315887451 1.5923793315887451 1.5923793315887451 0.0 1.5923793315887451 61.2776 61.2776 39.7754 39.7754 140.784 140.784 UP 1.0 0.0 0.0 GO:0014074 6 response to purine-containing compound 89 91 7 7 6 6 5 5 54 86 2402 0.98271 0.057282 0.057282 5.49 78968;79212;362282;24494;24450 srebf1;slc6a1;pck1;il1b;hmgcs2 SREBF1_32750;SLC6A1_32594;PCK1_9439;IL1B_8892;HMGCS2_8812 194.9464 177.986 145.445 52.55944061060774 168.2296435827729 38.675773021989 128.4288 117.256 104.722 25.43685981405725 115.29757352029378 18.51665080761411 429.24799999999993 348.781 237.101 230.41827260657962 321.2188594457957 162.25777655104477 3.5 248.65500000000003 177.986;145.445;227.854;153.991;269.456 117.256;104.722;148.568;109.464;162.134 348.781;237.101;506.507;258.668;795.183 4 1 4 79212;362282;24494;24450 SLC6A1_32594;PCK1_9439;IL1B_8892;HMGCS2_8812 199.18650000000002 190.9225 59.694807783703716 131.222 129.01600000000002 28.472770758510073 449.36475 382.5875 260.944852917719 145.445;227.854;153.991;269.456 104.722;148.568;109.464;162.134 237.101;506.507;258.668;795.183 1 78968 SREBF1_32750 177.986 177.986 117.256 117.256 348.781 348.781 177.986 117.256 348.781 0 Exp 2,2(0.4);Linear,3(0.6) 2.066537351539963 10.532880663871765 1.5889767408370972 2.8712503910064697 0.4759687732616089 2.0017645359039307 148.87601903064467 241.0167809693553 106.13240931008106 150.72519068991892 227.27747904389543 631.2185209561046 UP 0.8 0.2 0.0 GO:0071548 6 response to dexamethasone 48 52 3 3 3 2 2 2 57 50 2438 0.8824 0.34055 0.34055 3.85 362282;24494 pck1;il1b PCK1_9439;IL1B_8892 190.9225 190.9225 153.991 52.22902817878198 170.56327234242713 43.57608384049936 129.01600000000002 129.01600000000002 109.464 27.650703571518648 118.23756914393228 23.069726148394878 382.5875 382.5875 258.668 175.24863754249296 314.27439840075266 146.21465473844188 227.854;153.991 148.568;109.464 506.507;258.668 2 0 2 362282;24494 PCK1_9439;IL1B_8892 190.9225 190.9225 52.22902817878198 129.01600000000002 129.01600000000002 27.650703571518648 382.5875 382.5875 175.24863754249296 227.854;153.991 148.568;109.464 506.507;258.668 0 0 Exp 2,1(0.5);Linear,1(0.5) 2.4919814128992774 5.0340611934661865 2.162810802459717 2.8712503910064697 0.5009424371224166 2.5170305967330933 118.53676000000003 263.30824 90.69408000000001 167.33792000000003 139.70527999999996 625.46972 UP 1.0 0.0 0.0 GO:0098700 5 neurotransmitter loading into synaptic vesicle 4 4 1 1 1 1 1 1 58 3 2485 0.99693 0.089539 0.089539 25.0 84487 slc17a6 SLC17A6_32912 369.631 369.631 369.631 369.631 163.45 163.45 163.45 163.45 452.105 452.105 452.105 452.105 0.0 369.631 0.0 369.631 369.631 163.45 452.105 1 0 1 84487 SLC17A6_32912 369.631 369.631 163.45 163.45 452.105 452.105 369.631 163.45 452.105 0 0 Hill,1(1) 1.8682953119277954 1.8682953119277954 1.8682953119277954 1.8682953119277954 0.0 1.8682953119277954 369.631 369.631 163.45 163.45 452.105 452.105 UP 1.0 0.0 0.0 GO:0031401 8 positive regulation of protein modification process 319 340 11 11 9 7 6 6 53 334 2154 0.309 0.81978 0.56482 1.76 313506;78968;24494;84488;25311;24232 stil;srebf1;il1b;fgf13;dcc;c3 STIL_33274;SREBF1_32750;IL1B_8892;FGF13_32529;DCC_32537;C3_8175 207.64833333333334 193.873 144.319 63.6109068027383 210.42610576860682 61.911374547836935 129.23143333333334 123.665 57.6936 46.73308991631806 132.4351822464473 45.78687366790395 471.5456666666667 324.095 153.26 413.42929780298186 471.9568860229706 402.5438274965865 311.636;177.986;153.991;209.76;248.198;144.319 177.242;117.256;109.464;130.074;183.659;57.6936 1285.89;348.781;258.668;483.266;299.409;153.26 2 4 2 24494;24232 IL1B_8892;C3_8175 149.155 149.155 6.839136787636285 83.5788 83.5788 36.607200904740054 205.964 205.964 74.5347115913116 153.991;144.319 109.464;57.6936 258.668;153.26 4 313506;78968;84488;25311 STIL_33274;SREBF1_32750;FGF13_32529;DCC_32537 236.89499999999998 228.97899999999998 57.505226997204616 152.05775 153.65800000000002 33.30331573457314 604.3365000000001 416.0235 460.9637126604074 311.636;177.986;209.76;248.198 177.242;117.256;130.074;183.659 1285.89;348.781;483.266;299.409 0 Exp 2,2(0.34);Exp 5,1(0.17);Linear,2(0.34);Poly 2,1(0.17) 1.8600136544211319 11.41821801662445 1.5889767408370972 2.8712503910064697 0.48944571871825615 1.694869875907898 156.74900717746817 258.5476594891985 91.8371733631289 166.6256933035378 140.73333071741104 802.3580026159224 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:1903531 6 negative regulation of secretion by cell 58 60 5 5 5 3 3 3 56 57 2431 0.95164 0.16047 0.16047 5.0 78968;24494;24451 srebf1;il1b;hmox1 SREBF1_32750;IL1B_8892;HMOX1_8815 131.08486666666667 153.991 61.2776 61.63384513279485 130.92805388739947 61.251432395402155 88.8318 109.464 39.7754 42.662355791962526 88.8553450825455 42.503770718972824 249.41099999999997 258.668 140.784 104.30703254814613 248.3888088754057 103.1631602452405 2.0 177.986 177.986;153.991;61.2776 117.256;109.464;39.7754 348.781;258.668;140.784 2 1 2 24494;24451 IL1B_8892;HMOX1_8815 107.63430000000001 107.63430000000001 65.55827384686086 74.6197 74.6197 49.27728163139686 199.726 199.726 83.35657579339495 153.991;61.2776 109.464;39.7754 258.668;140.784 1 78968 SREBF1_32750 177.986 177.986 117.256 117.256 348.781 348.781 177.986 117.256 348.781 0 Exp 2,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 1.936771473575814 6.052606463432312 1.5889767408370972 2.8712503910064697 0.7393407511829624 1.5923793315887451 61.339605192589545 200.8301281407438 40.5547997025238 137.1088002974762 131.37648109271538 367.4455189072847 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0016071 7 mRNA metabolic process 53 60 3 3 3 3 3 3 56 57 2431 0.95164 0.16047 0.16047 5.0 78968;681410;316098 srebf1;loc681410;exosc7 SREBF1_32750;LOC681410_33126;EXOSC7_8580 233.52066666666667 177.986 111.985 156.85808940036637 226.23270451421925 143.41467823968253 166.26733333333334 117.256 54.886 142.36172191053794 159.96878486097896 129.97857908575844 405.884 373.527 348.781 78.45641993489113 395.39424516333656 76.70240306595778 2.0 410.591 177.986;410.591;111.985 117.256;326.66;54.886 348.781;495.344;373.527 2 1 2 681410;316098 LOC681410_33126;EXOSC7_8580 261.288 261.288 211.1463275029902 190.77300000000002 190.77300000000002 192.17323835019275 434.4355 434.4355 86.13762676380146 410.591;111.985 326.66;54.886 495.344;373.527 1 78968 SREBF1_32750 177.986 177.986 117.256 117.256 348.781 348.781 177.986 117.256 348.781 0 Exp 2,1(0.34);Poly 2,2(0.67) 1.7435330853880482 5.246765375137329 1.5889767408370972 1.9251312017440796 0.1686663938992875 1.7326574325561523 56.01902879251767 411.02230454081564 5.169879537331809 327.3647871293349 317.102203068635 494.66579693136504 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0001775 3 cell activation 161 172 8 8 7 6 5 5 54 167 2321 0.79529 0.3677 0.59456 2.91 294228;24494;245920;298566;29650 rt1-s3;il1b;cxcl10;c1qa;adam10 RT1-S3_9763;IL1B_8892;CXCL10_8408;C1QA_8167;ADAM10_7983 260.5 268.455 153.991 76.26259596289658 253.086851203277 71.60875525201375 155.8882 161.753 109.464 31.39114564172517 153.29916600102408 29.1372723727592 991.3702 786.937 258.668 725.9935306717272 914.9649167434715 737.8059984848531 219.207;153.991;344.076;268.455;316.771 141.536;109.464;187.725;161.753;178.963 484.566;258.668;2052.67;786.937;1374.01 2 3 2 24494;298566 IL1B_8892;C1QA_8167 211.223 211.223 80.93827060173687 135.6085 135.6085 36.973906481463416 522.8025 522.8025 373.54259219063636 153.991;268.455 109.464;161.753 258.668;786.937 3 294228;245920;29650 RT1-S3_9763;CXCL10_8408;ADAM10_7983 293.35133333333334 316.771 65.64622898791167 169.40800000000002 178.963 24.532212476659943 1303.7486666666666 1374.01 786.4095815319985 219.207;344.076;316.771 141.536;187.725;178.963 484.566;2052.67;1374.01 0 Linear,5(1) 2.11160151363987 10.787628531455994 1.6434866189956665 2.8712503910064697 0.5073982406262957 2.0174295902252197 193.65288730425402 327.347112695746 128.37264766577448 183.40375233422554 355.00881276363236 1627.7315872363674 DOWN 0.4 0.6 0.0 GO:0045595 5 regulation of cell differentiation 433 456 19 19 17 14 13 13 46 443 2045 0.84384 0.24669 0.39159 2.85 29142;365377;311715;338475;25595;24494;24408;304729;84488;25311;245920;502902;29650 vnn1;trim72;tcfl5;nrep;map2;il1b;grin1;gli2;fgf13;dcc;cxcl10;clec7a;adam10 VNN1_10157;TRIM72_33144;TCFL5_9994;NREP_9364;MAP2_32650;IL1B_8892;GRIN1_32381;GLI2_8713;FGF13_32529;DCC_32537;CXCL10_8408;CLEC7A_32927;ADAM10_7983 247.98006153846157 248.198 82.0928 89.1797318395977 250.44653407998848 102.68008954993263 170.81143076923078 163.744 49.3056 73.62212094186759 174.08162366789915 85.73272174599587 619.9666923076923 483.266 193.467 531.624034626349 627.1552862297483 589.028118528061 233.741;82.0928;270.921;222.026;145.437;153.991;310.025;273.717;209.76;248.198;344.076;412.985;316.771 147.819;49.3056;228.673;142.777;104.718;109.464;254.954;163.744;130.074;183.659;187.725;338.673;178.963 556.851;193.467;338.867;497.741;237.081;258.668;447.21;831.582;483.266;299.409;2052.67;488.745;1374.01 7 6 7 29142;365377;311715;25595;24494;24408;502902 VNN1_10157;TRIM72_33144;TCFL5_9994;MAP2_32650;IL1B_8892;GRIN1_32381;CLEC7A_32927 229.88468571428575 233.741 112.82785556778408 176.2295142857143 147.819 101.5087170384138 360.127 338.867 139.33661937074066 233.741;82.0928;270.921;145.437;153.991;310.025;412.985 147.819;49.3056;228.673;104.718;109.464;254.954;338.673 556.851;193.467;338.867;237.081;258.668;447.21;488.745 6 338475;304729;84488;25311;245920;29650 NREP_9364;GLI2_8713;FGF13_32529;DCC_32537;CXCL10_8408;ADAM10_7983 269.09133333333335 260.9575 53.083578883367366 164.49033333333333 171.3535 23.551031634870277 923.1129999999999 664.6614999999999 670.9692163174104 222.026;273.717;209.76;248.198;344.076;316.771 142.777;163.744;130.074;183.659;187.725;178.963 497.741;831.582;483.266;299.409;2052.67;1374.01 0 Exp 2,3(0.24);Linear,7(0.54);Poly 2,3(0.24) 1.962897771016278 25.89876616001129 1.5347857475280762 2.8712503910064697 0.37112666530321015 1.929691195487976 199.50140708273813 296.45871599418496 130.7899899349187 210.83287160354286 330.9725751089141 908.9608095064705 CONFLICT 0.5384615384615384 0.46153846153846156 0.0 GO:0033563 6 dorsal/ventral axon guidance 1 1 1 1 1 1 1 1 58 0 2488 1.0 0.023165 0.023165 100.0 25311 dcc DCC_32537 248.198 248.198 248.198 248.198 183.659 183.659 183.659 183.659 299.409 299.409 299.409 299.409 0.0 248.198 0.0 248.198 248.198 183.659 299.409 0 1 0 1 25311 DCC_32537 248.198 248.198 183.659 183.659 299.409 299.409 248.198 183.659 299.409 0 Poly 2,1(1) 1.933887243270874 1.933887243270874 1.933887243270874 1.933887243270874 0.0 1.933887243270874 248.198 248.198 183.659 183.659 299.409 299.409 DOWN 0.0 1.0 0.0 GO:0033564 6 anterior/posterior axon guidance 1 1 1 1 1 1 1 1 58 0 2488 1.0 0.023165 0.023165 100.0 25311 dcc DCC_32537 248.198 248.198 248.198 248.198 183.659 183.659 183.659 183.659 299.409 299.409 299.409 299.409 0.0 248.198 0.0 248.198 248.198 183.659 299.409 0 1 0 1 25311 DCC_32537 248.198 248.198 183.659 183.659 299.409 299.409 248.198 183.659 299.409 0 Poly 2,1(1) 1.933887243270874 1.933887243270874 1.933887243270874 1.933887243270874 0.0 1.933887243270874 248.198 248.198 183.659 183.659 299.409 299.409 DOWN 0.0 1.0 0.0 GO:0050870 8 positive regulation of T cell activation 64 67 3 3 3 3 3 3 56 64 2424 0.93247 0.20132 0.20132 4.48 29142;294228;24494 vnn1;rt1-s3;il1b VNN1_10157;RT1-S3_9763;IL1B_8892 202.313 219.207 153.991 42.47435758195769 201.69100268932218 38.94625958114427 132.93966666666665 141.536 109.464 20.571806345903163 132.79091449177923 18.99437870059863 433.3616666666667 484.566 258.668 155.546418108336 427.2192237638286 139.28234690388405 233.741;219.207;153.991 147.819;141.536;109.464 556.851;484.566;258.668 2 1 2 29142;24494 VNN1_10157;IL1B_8892 193.866 193.866 56.391765799627166 128.6415 128.6415 27.121080592409903 407.7595 407.7595 210.84722133454832 233.741;153.991 147.819;109.464 556.851;258.668 1 294228 RT1-S3_9763 219.207 219.207 141.536 141.536 484.566 484.566 219.207 141.536 484.566 0 Linear,3(1) 2.1465536735771438 6.5860573053359985 1.7851157188415527 2.8712503910064697 0.5897915328305651 1.929691195487976 154.2487397041447 250.37726029585528 109.66047632087978 156.21885701245358 257.3443245886599 609.3790087446733 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0048638 5 regulation of developmental growth 94 100 5 5 5 3 3 3 56 97 2391 0.80062 0.41085 0.50239 3.0 25595;84488;24232 map2;fgf13;c3 MAP2_32650;FGF13_32529;C3_8175 166.5053333333333 145.437 144.319 37.463810835702965 178.98078702250135 39.885558518691504 97.49520000000001 104.718 57.6936 36.72679139157135 100.03628058608061 41.84929158719762 291.20233333333334 237.081 153.26 171.53083993945037 334.8916761730334 194.2074979776689 145.437;209.76;144.319 104.718;130.074;57.6936 237.081;483.266;153.26 2 1 2 25595;24232 MAP2_32650;C3_8175 144.878 144.878 0.7905453813722293 81.20580000000001 81.20580000000001 33.25127212122867 195.1705 195.1705 59.27039750583753 145.437;144.319 104.718;57.6936 237.081;153.26 1 84488 FGF13_32529 209.76 209.76 130.074 130.074 483.266 483.266 209.76 130.074 483.266 0 Exp 2,1(0.34);Exp 5,1(0.34);Linear,1(0.34) 1.8275641340748467 5.515379190444946 1.6639630794525146 2.1256394386291504 0.25061797379575057 1.7257766723632812 124.11104044244321 208.89962622422348 55.93492312306589 139.05547687693414 97.09691517113936 485.3077514955273 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0097176 5 epoxide metabolic process 2 2 1 1 1 1 1 1 58 1 2487 0.99947 0.045801 0.045801 50.0 25315 ephx1 EPHX1_8567 12.5094 12.5094 12.5094 12.509399999999998 3.282 3.282 3.282 3.282 61.3966 61.3966 61.3966 61.3966 0.0 12.5094 0.0 12.5094 12.5094 3.282 61.3966 1 0 1 25315 EPHX1_8567 12.5094 12.5094 3.282 3.282 61.3966 61.3966 12.5094 3.282 61.3966 0 0 Hill,1(1) 2.1014184951782227 2.1014184951782227 2.1014184951782227 2.1014184951782227 0.0 2.1014184951782227 12.5094 12.5094 3.282 3.282 61.3966 61.3966 UP 1.0 0.0 0.0 GO:0048511 2 rhythmic process 111 122 5 5 3 5 3 3 56 119 2369 0.68775 0.54375 0.75946 2.46 360243;78968;24408 top2a;srebf1;grin1 TOP2A_10059;SREBF1_32750;GRIN1_32381 230.49299999999997 203.468 177.986 70.04525215173409 233.13127727505545 73.29856729020466 160.21733333333333 117.256 108.442 82.16263540888487 166.18203192760797 83.57439765673168 456.08133333333336 447.21 348.781 111.99981746562496 439.48097677992143 105.91171556442242 203.468;177.986;310.025 108.442;117.256;254.954 572.253;348.781;447.21 1 2 1 24408 GRIN1_32381 310.025 310.025 254.954 254.954 447.21 447.21 310.025 254.954 447.21 2 360243;78968 TOP2A_10059;SREBF1_32750 190.72699999999998 190.72699999999998 18.018494998195845 112.84899999999999 112.84899999999999 6.2324391693785035 460.51700000000005 460.51700000000005 158.0185666053199 203.468;177.986 108.442;117.256 572.253;348.781 0 Exp 2,3(1) 1.8506037270468758 5.586641788482666 1.5889767408370972 2.0807507038116455 0.2504086842775713 1.9169143438339233 151.22933543689263 309.7566645631073 67.24155877886182 253.19310788780484 329.3416087979169 582.8210578687499 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0051259 7 protein complex oligomerization 47 55 3 3 2 3 2 2 57 53 2435 0.86688 0.36608 0.36608 3.64 365377;24408 trim72;grin1 TRIM72_33144;GRIN1_32381 196.0589 196.0589 82.0928 161.17240427076834 164.41902239960086 154.83662418589316 152.1298 152.1298 49.3056 145.41537818016363 123.58319620853081 139.69901587064155 320.3385 320.3385 193.467 179.4233959786181 285.11575629832873 172.3701588928687 82.0928;310.025 49.3056;254.954 193.467;447.21 2 0 2 365377;24408 TRIM72_33144;GRIN1_32381 196.0589 196.0589 161.17240427076834 152.1298 152.1298 145.41537818016363 320.3385 320.3385 179.4233959786181 82.0928;310.025 49.3056;254.954 193.467;447.21 0 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.7871198380728466 3.5830280780792236 1.6661137342453003 1.9169143438339233 0.17734281176583522 1.7915140390396118 -27.31465599999993 419.4324559999999 -49.405632 353.66523199999995 71.67036000000004 569.00664 UP 1.0 0.0 0.0 GO:0046683 5 response to organophosphorus 70 72 6 6 5 5 4 4 55 68 2420 0.97598 0.083323 0.083323 5.56 78968;362282;24494;24450 srebf1;pck1;il1b;hmgcs2 SREBF1_32750;PCK1_9439;IL1B_8892;HMGCS2_8812 207.32175 202.92000000000002 153.991 51.59778237078936 184.35090618128513 43.45312778916426 134.3555 132.912 109.464 25.070699305497342 122.78031500936558 21.079004134271088 477.28475000000003 427.644 258.668 235.3860194041198 380.7364067106442 191.19169256033217 2.5 248.65500000000003 177.986;227.854;153.991;269.456 117.256;148.568;109.464;162.134 348.781;506.507;258.668;795.183 3 1 3 362282;24494;24450 PCK1_9439;IL1B_8892;HMGCS2_8812 217.10033333333334 227.854 58.4788215197034 140.05533333333335 148.568 27.347419354179 520.1193333333333 506.507 268.5164017715369 227.854;153.991;269.456 148.568;109.464;162.134 506.507;258.668;795.183 1 78968 SREBF1_32750 177.986 177.986 117.256 117.256 348.781 348.781 177.986 117.256 348.781 0 Exp 2,2(0.5);Linear,2(0.5) 2.083055428998278 8.531116127967834 1.5889767408370972 2.8712503910064697 0.5454213215281325 2.035444498062134 156.7559232766265 257.8875767233735 109.78621468061257 158.92478531938744 246.60645098396265 707.9630490160374 UP 0.75 0.25 0.0 GO:1901362 5 organic cyclic compound biosynthetic process 212 234 5 5 3 4 3 3 56 231 2257 0.19406 0.91937 0.36302 1.28 78968;291773;24450 srebf1;taf4b;hmgcs2 SREBF1_32750;RGD1562997_32695;HMGCS2_8812 242.448 269.456 177.986 56.06952658976159 219.54569359543433 59.2722382451126 148.47833333333332 162.134 117.256 27.10995304926476 137.3409704502219 28.617632381639357 677.4753333333333 795.183 348.781 288.45314443481703 562.2484252377932 305.91805490417073 177.986;279.902;269.456 117.256;166.045;162.134 348.781;888.462;795.183 1 2 1 24450 HMGCS2_8812 269.456 269.456 162.134 162.134 795.183 795.183 269.456 162.134 795.183 2 78968;291773 SREBF1_32750;RGD1562997_32695 228.944 228.944 72.06549471140809 141.6505 141.6505 34.499032747310494 618.6215 618.6215 381.61209477753727 177.986;279.902 117.256;166.045 348.781;888.462 0 Exp 2,1(0.34);Linear,2(0.67) 1.7061973431247535 5.135281920433044 1.5889767408370972 1.9080781936645508 0.1717900841887574 1.6382269859313965 178.9993577109297 305.8966422890703 117.80053349953967 179.156133167127 351.0598721807836 1003.890794485883 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0007519 7 skeletal muscle tissue development 20 23 1 1 1 1 1 1 58 22 2466 0.90214 0.41808 0.41808 4.35 24584 mylpf MYLPF_32295 353.211 353.211 353.211 353.211 200.468 200.468 200.468 200.468 2217.36 2217.36 2217.36 2217.36 353.211 200.468 2217.36 1 0 1 24584 MYLPF_32295 353.211 353.211 200.468 200.468 2217.36 2217.36 353.211 200.468 2217.36 0 0 Exp 2,1(1) 1.601873517036438 1.601873517036438 1.601873517036438 1.601873517036438 0.0 1.601873517036438 353.211 353.211 200.468 200.468 2217.36 2217.36 UP 1.0 0.0 0.0 GO:0048856 3 anatomical structure development 699 756 34 33 31 23 22 22 37 734 1754 0.92247 0.12609 0.19682 2.91 246118;365377;360243;313506;78968;29483;84487;294228;338475;24584;25595;24503;24451;24450;24408;304729;84488;25315;50549;29182;24232;29650 tubb3;trim72;top2a;stil;srebf1;slc1a3;slc17a6;rt1-s3;nrep;mylpf;map2;ina;hmox1;hmgcs2;grin1;gli2;fgf13;ephx1;cyp4a1;cdh22;c3;adam10 TUBB3_32820;TRIM72_33144;TOP2A_10059;STIL_33274;SREBF1_32750;SLC1A3_32817;SLC17A6_32912;RT1-S3_9763;NREP_9364;MYLPF_32295;MAP2_32650;INA_32322;HMOX1_8815;HMGCS2_8812;GRIN1_32381;GLI2_8713;FGF13_32529;EPHX1_8567;CYP4A1_33111;CDH22_32502;C3_8175;ADAM10_7983 238.93394545454547 271.5865 12.5094 100.97403907334525 245.25348414887233 97.27899592327331 149.37093636363636 162.79199999999997 3.282 68.72116260803192 153.8908070749102 67.47439600612987 777.5574818181819 483.916 61.3966 867.9984663893092 699.4405924278657 817.3334987004908 282.273;82.0928;203.468;311.636;177.986;303.435;369.631;219.207;222.026;353.211;145.437;305.642;61.2776;269.456;310.025;273.717;209.76;12.5094;375.605;307.062;144.319;316.771 238.208;49.3056;108.442;177.242;117.256;189.179;163.45;141.536;142.777;200.468;104.718;249.176;39.7754;162.134;254.954;163.744;130.074;3.282;197.092;216.691;57.6936;178.963 354.06;193.467;572.253;1285.89;348.781;992.735;452.105;484.566;497.741;2217.36;237.081;459.059;140.784;795.183;447.21;831.582;483.266;61.3966;3966.72;757.755;153.26;1374.01 14 8 14 246118;365377;29483;84487;24584;25595;24503;24451;24450;24408;25315;50549;29182;24232 TUBB3_32820;TRIM72_33144;SLC1A3_32817;SLC17A6_32912;MYLPF_32295;MAP2_32650;INA_32322;HMOX1_8815;HMGCS2_8812;GRIN1_32381;EPHX1_8567;CYP4A1_33111;CDH22_32502;C3_8175 237.28398571428573 292.85400000000004 122.48079367537811 151.8661857142857 176.3145 85.054072348485 802.0125428571429 449.6575 1064.0868688056526 282.273;82.0928;303.435;369.631;353.211;145.437;305.642;61.2776;269.456;310.025;12.5094;375.605;307.062;144.319 238.208;49.3056;189.179;163.45;200.468;104.718;249.176;39.7754;162.134;254.954;3.282;197.092;216.691;57.6936 354.06;193.467;992.735;452.105;2217.36;237.081;459.059;140.784;795.183;447.21;61.3966;3966.72;757.755;153.26 8 360243;313506;78968;294228;338475;304729;84488;29650 TOP2A_10059;STIL_33274;SREBF1_32750;RT1-S3_9763;NREP_9364;GLI2_8713;FGF13_32529;ADAM10_7983 241.82137499999996 220.6165 52.07960132044457 145.00425 142.1565 26.431346988809494 734.761125 534.9970000000001 392.6415902206263 203.468;311.636;177.986;219.207;222.026;273.717;209.76;316.771 108.442;177.242;117.256;141.536;142.777;163.744;130.074;178.963 572.253;1285.89;348.781;484.566;497.741;831.582;483.266;1374.01 0 Exp 2,9(0.41);Exp 5,1(0.05);Hill,2(0.1);Linear,8(0.37);Poly 2,2(0.1) 1.7955864623327202 39.851438999176025 1.5347857475280762 2.545419454574585 0.2572017735187285 1.7063142657279968 196.73958002558246 281.12831088350833 120.6541902138637 178.08768251340908 414.84400795182876 1140.2709556845348 UP 0.6363636363636364 0.36363636363636365 0.0 GO:0016477 4 cell migration 189 200 8 8 7 5 5 5 54 195 2293 0.68378 0.49902 0.80559 2.5 366669;24494;84488;25311;245920 syne2;il1b;fgf13;dcc;cxcl10 SYNE2_9977;IL1B_8892;FGF13_32529;DCC_32537;CXCL10_8408 246.5564 248.198 153.991 71.3217565073941 249.96280089558758 72.99189962230622 155.1604 164.88 109.464 34.22200475279019 156.85747513470218 34.62654612909986 790.5848 483.266 258.668 744.338887054613 835.2881822484345 797.7136317289519 276.757;153.991;209.76;248.198;344.076 164.88;109.464;130.074;183.659;187.725 858.911;258.668;483.266;299.409;2052.67 1 4 1 24494 IL1B_8892 153.991 153.991 109.464 109.464 258.668 258.668 153.991 109.464 258.668 4 366669;84488;25311;245920 SYNE2_9977;FGF13_32529;DCC_32537;CXCL10_8408 269.69775 262.4775 56.67665659613917 166.5845 174.2695 26.295634751798747 923.564 671.0885 787.9281190722073 276.757;209.76;248.198;344.076 164.88;130.074;183.659;187.725 858.911;483.266;299.409;2052.67 0 Exp 2,1(0.2);Linear,3(0.6);Poly 2,1(0.2) 2.090373784027485 10.688149809837341 1.6639630794525146 2.8712503910064697 0.5162447869963858 1.933887243270874 184.04012403651336 309.07267596348663 125.16349025020452 185.1573097497955 138.14299889774395 1443.0266011022559 DOWN 0.2 0.8 0.0 GO:0044237 3 cellular metabolic process 1201 1328 46 44 38 32 29 29 30 1299 1189 0.36915 0.72482 0.69327 2.18 29142;286989;365377;360243;78968;29483;291773;303872;362282;25247;497009;316273;681410;24494;24451;24450;24408;84488;316098;25315;171142;29740;50549;25086;25279;297594;24232;64564;29650 vnn1;ugt2b7;trim72;top2a;srebf1;slc1a3;taf4b;pigz;pck1;nsg1;naaa;mcm3;loc681410;il1b;hmox1;hmgcs2;grin1;fgf13;exosc7;ephx1;ehhadh;eci1;cyp4a1;cyp2e1;cyp24a1;cdca3;c3;bbox1;adam10 VNN1_10157;UGT2B7_33032;TRIM72_33144;TOP2A_10059;SREBF1_32750;SLC1A3_32817;RGD1562997_32695;PIGZ_32744;PCK1_9439;NSG1_32675;NAAA_32484;MCM3_9207;LOC681410_33126;IL1B_8892;HMOX1_8815;HMGCS2_8812;GRIN1_32381;FGF13_32529;EXOSC7_8580;EPHX1_8567;EHHADH_8534;ECI1_8520;CYP4A1_33111;CYP2E1_8421;CYP24A1_32574;CDCA3_8260;C3_8175;BBOX1_8133;ADAM10_7983 223.13756793103443 216.472 4.13867 111.70902869527922 212.49920441966742 100.67926497074406 139.36949241379313 133.518 1.39768 74.30795750869453 133.32080531265572 66.62905667745414 661.7753517241379 459.59 16.5686 801.7139702744216 612.7850801645424 779.223486607119 233.741;4.13867;82.0928;203.468;177.986;303.435;279.902;355.097;227.854;216.472;151.002;229.093;410.591;153.991;61.2776;269.456;310.025;209.76;111.985;12.5094;250.691;195.758;375.605;357.376;189.111;183.234;144.319;454.248;316.771 147.819;1.39768;49.3056;108.442;117.256;189.179;166.045;212.48;148.568;166.237;107.821;133.518;326.66;109.464;39.7754;162.134;254.954;130.074;54.886;3.282;157.555;130.778;197.092;191.769;127.579;111.531;57.6936;259.457;178.963 556.851;16.5686;193.467;572.253;348.781;992.735;888.462;459.59;506.507;342.576;250.969;614.889;495.344;258.668;140.784;795.183;447.21;483.266;373.527;61.3966;636.947;388.001;3966.72;2610.68;364.247;407.422;153.26;491.171;1374.01 22 7 22 29142;286989;365377;29483;303872;362282;25247;497009;681410;24494;24451;24450;24408;316098;25315;171142;29740;50549;25086;25279;24232;64564 VNN1_10157;UGT2B7_33032;TRIM72_33144;SLC1A3_32817;PIGZ_32744;PCK1_9439;NSG1_32675;NAAA_32484;LOC681410_33126;IL1B_8892;HMOX1_8815;HMGCS2_8812;GRIN1_32381;EXOSC7_8580;EPHX1_8567;EHHADH_8534;ECI1_8520;CYP4A1_33111;CYP2E1_8421;CYP24A1_32574;C3_8175;BBOX1_8133 221.39888499999998 222.163 125.94806083820316 140.72210363636364 148.1935 84.50027005713568 659.2000999999999 417.6055 905.8886173758129 233.741;4.13867;82.0928;303.435;355.097;227.854;216.472;151.002;410.591;153.991;61.2776;269.456;310.025;111.985;12.5094;250.691;195.758;375.605;357.376;189.111;144.319;454.248 147.819;1.39768;49.3056;189.179;212.48;148.568;166.237;107.821;326.66;109.464;39.7754;162.134;254.954;54.886;3.282;157.555;130.778;197.092;191.769;127.579;57.6936;259.457 556.851;16.5686;193.467;992.735;459.59;506.507;342.576;250.969;495.344;258.668;140.784;795.183;447.21;373.527;61.3966;636.947;388.001;3966.72;2610.68;364.247;153.26;491.171 7 360243;78968;291773;316273;84488;297594;29650 TOP2A_10059;SREBF1_32750;RGD1562997_32695;MCM3_9207;FGF13_32529;CDCA3_8260;ADAM10_7983 228.602 209.76 51.6602320326446 135.11842857142855 130.074 27.36747424015807 669.869 572.253 356.5916765125062 203.468;177.986;279.902;229.093;209.76;183.234;316.771 108.442;117.256;166.045;133.518;130.074;111.531;178.963 572.253;348.781;888.462;614.889;483.266;407.422;1374.01 0 Exp 2,10(0.35);Exp 5,1(0.04);Hill,2(0.07);Linear,10(0.35);Poly 2,5(0.18);Power,1(0.04) 1.9480779547036111 58.028045892715454 1.5261523723602295 3.570159435272217 0.525376612969383 1.8518693447113037 182.47963004347483 263.79550581859417 112.32415546809997 166.41482935948628 369.9812399346415 953.569463513634 UP 0.7586206896551724 0.2413793103448276 0.0 GO:0006928 3 movement of cell or subcellular component 248 268 12 12 10 9 8 8 51 260 2228 0.83879 0.27698 0.39375 2.99 246118;366669;311024;24494;304729;84488;25311;245920 tubb3;syne2;kif5c;il1b;gli2;fgf13;dcc;cxcl10 TUBB3_32820;SYNE2_9977;KIF5C_8965;IL1B_8892;GLI2_8713;FGF13_32529;DCC_32537;CXCL10_8408 255.698625 265.267 153.991 55.80218019534338 259.56398872823223 55.00413853306777 173.257875 174.2695 109.464 41.161336509737524 179.7947965804749 43.5059111619139 688.850625 427.7525 258.668 597.687287565744 684.0462161688654 626.8873141986011 282.273;276.757;256.817;153.991;273.717;209.76;248.198;344.076 238.208;164.88;208.309;109.464;163.744;130.074;183.659;187.725 354.06;858.911;372.239;258.668;831.582;483.266;299.409;2052.67 3 5 3 246118;311024;24494 TUBB3_32820;KIF5C_8965;IL1B_8892 231.02700000000002 256.817 67.91841396852566 185.327 208.309 67.37865854259798 328.32233333333335 354.06 61.00339026917501 282.273;256.817;153.991 238.208;208.309;109.464 354.06;372.239;258.668 5 366669;304729;84488;25311;245920 SYNE2_9977;GLI2_8713;FGF13_32529;DCC_32537;CXCL10_8408 270.5016 273.717 49.11632545600293 166.0164 164.88 22.808090522882498 905.1676 831.582 683.6045481733573 276.757;273.717;209.76;248.198;344.076 164.88;163.744;130.074;183.659;187.725 858.911;831.582;483.266;299.409;2052.67 0 Exp 2,3(0.38);Linear,4(0.5);Poly 2,1(0.13) 2.1878226641175478 17.78221881389618 1.6639630794525146 2.8712503910064697 0.418038734224477 2.2743247747421265 217.02968697930146 294.3675630206985 144.73452403463787 201.7812259653621 274.6744656146029 1103.0267843853971 DOWN 0.375 0.625 0.0 GO:0006974 5 cellular response to DNA damage stimulus 142 151 6 6 5 4 3 3 56 148 2340 0.53268 0.69042 1.0 1.99 360243;316273;24451 top2a;mcm3;hmox1 TOP2A_10059;MCM3_9207;HMOX1_8815 164.61286666666663 203.468 61.2776 90.40350191808575 178.73647010875925 89.24296691978826 93.91180000000001 108.442 39.7754 48.53106013389773 103.60081775230968 49.3472758260117 442.642 572.253 140.784 262.2844758025149 477.5673904806456 254.53386252620652 203.468;229.093;61.2776 108.442;133.518;39.7754 572.253;614.889;140.784 1 2 1 24451 HMOX1_8815 61.2776 61.2776 39.7754 39.7754 140.784 140.784 61.2776 39.7754 140.784 2 360243;316273 TOP2A_10059;MCM3_9207 216.2805 216.2805 18.11961126790528 120.97999999999999 120.97999999999999 17.731409645033985 593.571 593.571 30.1482047226699 203.468;229.093 108.442;133.518 572.253;614.889 0 Exp 2,2(0.67);Poly 2,1(0.34) 1.8307356623482023 5.524999380111694 1.5923793315887451 2.0807507038116455 0.244345500149837 1.8518693447113037 62.311673777207034 266.9140595561263 38.993735560566954 148.829864439433 145.83917509066998 739.4448249093301 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0034605 5 cellular response to heat 21 23 2 2 2 2 2 2 57 21 2467 0.98496 0.097858 0.097858 8.7 24451;245920 hmox1;cxcl10 HMOX1_8815;CXCL10_8408 202.67680000000001 202.67680000000001 61.2776 199.96866634870577 227.07143080581244 196.97022997645155 113.75019999999999 113.75019999999999 39.7754 104.61616543383722 126.51256311756934 103.04749509517742 1096.727 1096.727 140.784 1351.9075554556234 1261.6492665785997 1331.636335667946 0.5 202.67680000000001 61.2776;344.076 39.7754;187.725 140.784;2052.67 1 1 1 24451 HMOX1_8815 61.2776 61.2776 39.7754 39.7754 140.784 140.784 61.2776 39.7754 140.784 1 245920 CXCL10_8408 344.076 344.076 187.725 187.725 2052.67 2052.67 344.076 187.725 2052.67 0 Linear,1(0.5);Poly 2,1(0.5) 1.9833628640452392 4.06272554397583 1.5923793315887451 2.470346212387085 0.6208163350697073 2.031362771987915 -74.46563200000003 479.81923200000006 -31.240408000000002 258.740808 -776.92128 2970.3752799999997 CONFLICT 0.5 0.5 0.0 GO:0007165 4 signal transduction 714 752 29 29 24 22 18 18 41 734 1754 0.62878 0.48321 0.88547 2.39 246118;313506;78968;25247;24567;361680;24494;24451;24416;24408;304729;84488;316137;25311;245920;24232;29650;170924 tubb3;stil;srebf1;nsg1;mt1;lsp1;il1b;hmox1;grm3;grin1;gli2;fgf13;adgre1;dcc;cxcl10;c3;adam10;abcc4 TUBB3_32820;STIL_33274;SREBF1_32750;NSG1_32675;MT1A_9255;LSP1_32853;IL1B_8892;HMOX1_8815;GRM3_33234;GRIN1_32381;GLI2_8713;FGF13_32529;EMR1_8558;DCC_32537;CXCL10_8408;C3_8175;ADAM10_7983;ABCC4_32768 240.30514444444447 246.425 61.2776 85.3428326934386 247.3971017629832 83.08246486065606 157.84645 164.9905 39.7754 60.40931205499645 167.537758847002 63.37301722369648 929.1585555555555 405.53499999999997 140.784 1504.6532853324686 913.7982639457687 1498.7808032607395 282.273;311.636;177.986;216.472;392.753;231.535;153.991;61.2776;286.986;310.025;273.717;209.76;119.065;248.198;344.076;144.319;316.771;244.652 238.208;177.242;117.256;166.237;211.395;141.502;109.464;39.7754;241.819;254.954;163.744;130.074;89.1701;183.659;187.725;57.6936;178.963;152.355 354.06;1285.89;348.781;342.576;6610.49;580.905;258.668;140.784;363.86;447.21;831.582;483.266;178.281;299.409;2052.67;153.26;1374.01;619.152 10 8 10 246118;25247;24567;24494;24451;24416;24408;316137;24232;170924 TUBB3_32820;NSG1_32675;MT1A_9255;IL1B_8892;HMOX1_8815;GRM3_33234;GRIN1_32381;EMR1_8558;C3_8175;ABCC4_32768 221.18135999999998 230.562 101.31624771600828 156.10710999999998 159.296 79.51636057413944 946.8341 348.318 1995.3860335086624 282.273;216.472;392.753;153.991;61.2776;286.986;310.025;119.065;144.319;244.652 238.208;166.237;211.395;109.464;39.7754;241.819;254.954;89.1701;57.6936;152.355 354.06;342.576;6610.49;258.668;140.784;363.86;447.21;178.281;153.26;619.152 8 313506;78968;361680;304729;84488;25311;245920;29650 STIL_33274;SREBF1_32750;LSP1_32853;GLI2_8713;FGF13_32529;DCC_32537;CXCL10_8408;ADAM10_7983 264.209875 260.9575 57.575125639556504 160.020625 170.493 26.89692225588812 907.0641250000001 706.2435 614.8829493664249 311.636;177.986;231.535;273.717;209.76;248.198;344.076;316.771 177.242;117.256;141.502;163.744;130.074;183.659;187.725;178.963 1285.89;348.781;580.905;831.582;483.266;299.409;2052.67;1374.01 0 Exp 2,8(0.45);Exp 5,1(0.06);Linear,7(0.39);Poly 2,2(0.12) 2.0884021455687924 39.16524040699005 1.5415009260177612 3.667783737182617 0.6807910415080212 1.9149555563926697 200.87876723862078 279.73152165026806 129.9387716554105 185.75412834458945 234.04420184532796 1624.2729092657833 CONFLICT 0.5555555555555556 0.4444444444444444 0.0 GO:0010639 7 negative regulation of organelle organization 85 89 3 3 3 3 3 3 56 86 2402 0.85112 0.34035 0.45999 3.37 360243;25595;84488 top2a;map2;fgf13 TOP2A_10059;MAP2_32650;FGF13_32529 186.22166666666666 203.468 145.437 35.460387650635376 201.43762212121212 23.279071869168593 114.41133333333335 108.442 104.718 13.691471408629857 121.29737575757576 13.549540784872976 430.8666666666666 483.266 237.081 173.62124004952102 483.8607991919193 112.33227248282326 203.468;145.437;209.76 108.442;104.718;130.074 572.253;237.081;483.266 1 2 1 25595 MAP2_32650 145.437 145.437 104.718 104.718 237.081 237.081 145.437 104.718 237.081 2 360243;84488 TOP2A_10059;FGF13_32529 206.61399999999998 206.61399999999998 4.449115867226278 119.25800000000001 119.25800000000001 15.296133890627353 527.7595 527.7595 62.92331113744774 203.468;209.76 108.442;130.074 572.253;483.266 0 Exp 2,2(0.67);Linear,1(0.34) 1.9451411060593826 5.8703532218933105 1.6639630794525146 2.1256394386291504 0.2545820047826889 2.0807507038116455 146.09446052956756 226.34887280376577 98.9179749147191 129.90469175194758 234.39573809459677 627.3375952387366 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0038007 6 netrin-activated signaling pathway 2 2 2 2 2 2 2 2 57 0 2488 1.0 5.2771E-4 5.2771E-4 100.0 246118;25311 tubb3;dcc TUBB3_32820;DCC_32537 265.2355 265.2355 248.198 24.09466356893187 268.92118146137244 23.524122020398497 210.93349999999998 210.93349999999998 183.659 38.57196780694511 216.83372708837575 37.65861576201653 326.7345 326.7345 299.409 38.64409269862574 332.64575979590506 37.72903279638418 0.0 248.198 0.0 248.198 282.273;248.198 238.208;183.659 354.06;299.409 1 1 1 246118 TUBB3_32820 282.273 282.273 238.208 238.208 354.06 354.06 282.273 238.208 354.06 1 25311 DCC_32537 248.198 248.198 183.659 183.659 299.409 299.409 248.198 183.659 299.409 0 Exp 2,1(0.5);Poly 2,1(0.5) 2.2186829904191576 4.479306697845459 1.933887243270874 2.545419454574585 0.4324185735268587 2.2396533489227295 231.84199999999998 298.629 157.47547999999998 264.39151999999996 273.17652000000004 380.29248 CONFLICT 0.5 0.5 0.0 GO:0005996 4 monosaccharide metabolic process 56 69 2 2 2 2 2 2 57 67 2421 0.78657 0.47939 0.67349 2.9 286989;362282 ugt2b7;pck1 UGT2B7_33032;PCK1_9439 115.996335 115.996335 4.13867 158.19062689838628 68.12760408554867 142.97357671886144 74.98284000000001 74.98284000000001 1.39768 104.0651312613942 43.49256865080952 94.05464988590361 261.5378 261.5378 16.5686 346.4387650036872 156.7048883070158 313.11330081812554 4.13867;227.854 1.39768;148.568 16.5686;506.507 2 0 2 286989;362282 UGT2B7_33032;PCK1_9439 115.996335 115.996335 158.19062689838628 74.98284000000001 74.98284000000001 104.0651312613942 261.5378 261.5378 346.4387650036872 4.13867;227.854 1.39768;148.568 16.5686;506.507 0 0 Exp 2,1(0.5);Hill,1(0.5) 2.7787730013641334 5.732970237731934 2.162810802459717 3.570159435272217 0.9951457617553352 2.866485118865967 -103.2446884 335.23735840000006 -69.2440736 219.2097536 -218.60183199999994 741.677432 UP 1.0 0.0 0.0 GO:0006352 7 DNA-templated transcription, initiation 6 6 1 1 1 1 1 1 58 5 2483 0.99255 0.1313 0.1313 16.67 291773 taf4b RGD1562997_32695 279.902 279.902 279.902 279.902 166.045 166.045 166.045 166.045 888.462 888.462 888.462 888.4619999999999 0.0 279.902 0.0 279.902 279.902 166.045 888.462 0 1 0 1 291773 RGD1562997_32695 279.902 279.902 166.045 166.045 888.462 888.462 279.902 166.045 888.462 0 Linear,1(1) 1.6382269859313965 1.6382269859313965 1.6382269859313965 1.6382269859313965 0.0 1.6382269859313965 279.902 279.902 166.045 166.045 888.462 888.462 DOWN 0.0 1.0 0.0 GO:0006475 9 internal protein amino acid acetylation 15 15 2 2 2 2 2 2 57 13 2475 0.99559 0.045655 0.045655 13.33 362282;171142 pck1;ehhadh PCK1_9439;EHHADH_8534 239.2725 239.2725 227.854 16.14819756195699 246.64096319246502 12.335954963542267 153.06150000000002 153.06150000000002 148.568 6.354768642522733 155.96119692650888 4.854544259638983 571.727 571.727 506.507 92.23500853797331 613.8140665509976 70.46030413121895 0.0 227.854 0.5 239.2725 227.854;250.691 148.568;157.555 506.507;636.947 2 0 2 362282;171142 PCK1_9439;EHHADH_8534 239.2725 239.2725 16.14819756195699 153.06150000000002 153.06150000000002 6.354768642522733 571.727 571.727 92.23500853797331 227.854;250.691 148.568;157.555 506.507;636.947 0 0 Exp 2,2(1) 1.8644287565596371 3.770022392272949 1.6072115898132324 2.162810802459717 0.3928679708842357 1.8850111961364746 216.89224000000002 261.65276 144.25424000000004 161.86876 443.8958 699.5581999999999 UP 1.0 0.0 0.0 GO:0009408 4 response to heat 54 59 3 3 3 3 3 3 56 56 2432 0.95409 0.15486 0.15486 5.08 24494;24451;245920 il1b;hmox1;cxcl10 IL1B_8892;HMOX1_8815;CXCL10_8408 186.4482 153.991 61.2776 144.16600200643708 204.89446532940747 148.19319818433098 112.32146666666665 109.464 39.7754 74.01617979775324 121.3390112992271 75.09636084100897 817.3740000000001 258.668 140.784 1071.4202327173032 957.2848741258741 1115.9341391728924 1.5 249.0335 153.991;61.2776;344.076 109.464;39.7754;187.725 258.668;140.784;2052.67 2 1 2 24494;24451 IL1B_8892;HMOX1_8815 107.63430000000001 107.63430000000001 65.55827384686086 74.6197 74.6197 49.27728163139686 199.726 199.726 83.35657579339495 153.991;61.2776 109.464;39.7754 258.668;140.784 1 245920 CXCL10_8408 344.076 344.076 187.725 187.725 2052.67 2052.67 344.076 187.725 2052.67 0 Linear,2(0.67);Poly 2,1(0.34) 2.2436673805610914 6.9339759349823 1.5923793315887451 2.8712503910064697 0.6540974941130034 2.470346212387085 23.309011069839272 349.5873889301607 28.56427445865033 196.07865887468296 -395.05212915811103 2029.800129158111 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0009888 4 tissue development 153 164 8 8 7 6 6 6 53 158 2330 0.9185 0.17602 0.27307 3.66 246118;313506;24584;24503;24450;304729 tubb3;stil;mylpf;ina;hmgcs2;gli2 TUBB3_32820;STIL_33274;MYLPF_32295;INA_32322;HMGCS2_8812;GLI2_8713 299.3225 293.9575 269.456 31.412939045877526 296.6113336337744 26.676802585103015 198.49533333333332 188.855 162.134 37.76512462400556 208.38193193207624 37.80477306556738 990.5223333333333 813.3824999999999 354.06 684.591817070776 839.9044315174679 639.3506700648596 282.273;311.636;353.211;305.642;269.456;273.717 238.208;177.242;200.468;249.176;162.134;163.744 354.06;1285.89;2217.36;459.059;795.183;831.582 4 2 4 246118;24584;24503;24450 TUBB3_32820;MYLPF_32295;INA_32322;HMGCS2_8812 302.6455 293.9575 36.88916041784251 212.49649999999997 219.338 39.52861061307386 956.4155000000001 627.121 861.4276111217936 282.273;353.211;305.642;269.456 238.208;200.468;249.176;162.134 354.06;2217.36;459.059;795.183 2 313506;304729 STIL_33274;GLI2_8713 292.67650000000003 292.67650000000003 26.812782035812145 170.493 170.493 9.544527332455957 1058.736 1058.736 321.2442675472976 311.636;273.717 177.242;163.744 1285.89;831.582 0 Exp 2,3(0.5);Linear,3(0.5) 1.904853623055618 11.597039341926575 1.601873517036438 2.545419454574585 0.3728118388437696 1.8086034059524536 274.1869138187072 324.4580861812929 168.27694010219955 228.7137265644671 442.7347929233332 1538.3098737433334 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0007163 3 establishment or maintenance of cell polarity 25 27 3 3 3 3 3 3 56 24 2464 0.99694 0.023275 0.023275 11.11 366669;25595;84488 syne2;map2;fgf13 SYNE2_9977;MAP2_32650;FGF13_32529 210.65133333333333 209.76 145.437 65.66453728104179 227.34560053323528 49.716830623221995 133.22400000000002 130.074 104.718 30.204443977666585 139.95330863289513 24.0912737929968 526.4193333333333 483.266 237.081 313.1529895407889 592.421930403604 254.57405107028765 0.5 177.5985 1.5 243.2585 276.757;145.437;209.76 164.88;104.718;130.074 858.911;237.081;483.266 1 2 1 25595 MAP2_32650 145.437 145.437 104.718 104.718 237.081 237.081 145.437 104.718 237.081 2 366669;84488 SYNE2_9977;FGF13_32529 243.2585 243.2585 47.37403301915517 147.477 147.477 24.61155862597904 671.0885 671.0885 265.6211268188208 276.757;209.76 164.88;130.074 858.911;483.266 0 Exp 2,1(0.34);Linear,2(0.67) 1.8356213646219535 5.538305401802063 1.6639630794525146 2.1256394386291504 0.2457665089322357 1.748702883720398 136.34491431350676 284.9577523531599 99.04445403199162 167.40354596800842 172.05336622786876 880.7853004387978 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0051276 6 chromosome organization 85 90 4 4 3 3 3 3 56 87 2401 0.84676 0.3468 0.46357 3.33 360243;316273;500545 top2a;mcm3;cdca8 TOP2A_10059;MCM3_9207;CDCA8_33310 295.48633333333333 229.093 203.468 137.78552993087956 298.92416882413477 133.094682683446 155.39333333333332 133.518 108.442 60.910048246027024 159.4250845474733 56.46307292741979 553.9783333333334 572.253 474.793 71.81361211729542 562.3530881763528 77.0777230491973 203.468;229.093;453.898 108.442;133.518;224.22 572.253;614.889;474.793 0 3 0 3 360243;316273;500545 TOP2A_10059;MCM3_9207;CDCA8_33310 295.48633333333333 229.093 137.78552993087956 155.39333333333332 133.518 60.910048246027024 553.9783333333334 572.253 71.81361211729542 203.468;229.093;453.898 108.442;133.518;224.22 572.253;614.889;474.793 0 Exp 2,2(0.67);Power,1(0.34) 1.9710840482108969 5.920018911361694 1.8518693447113037 2.0807507038116455 0.11508655658568884 1.9873988628387451 139.5673282531172 451.40533841354943 86.46712514098765 224.31954152567897 472.7135810900298 635.243085576637 DOWN 0.0 1.0 0.0 GO:0046165 5 alcohol biosynthetic process 38 41 4 4 3 3 3 3 56 38 2450 0.98611 0.067623 0.067623 7.32 362282;24450;25315 pck1;hmgcs2;ephx1 PCK1_9439;HMGCS2_8812;EPHX1_8567 169.93980000000002 227.854 12.5094 137.91638674979853 184.47422503904212 130.06002741031313 104.66133333333335 148.568 3.282 88.05870774280834 114.12250234252993 82.95342736958612 454.36220000000003 506.507 61.3966 369.66191355280296 489.2227122332119 352.9287240994285 1.5 248.65500000000003 227.854;269.456;12.5094 148.568;162.134;3.282 506.507;795.183;61.3966 3 0 3 362282;24450;25315 PCK1_9439;HMGCS2_8812;EPHX1_8567 169.93980000000002 227.854 137.91638674979853 104.66133333333335 148.568 88.05870774280834 454.36220000000003 506.507 369.66191355280296 227.854;269.456;12.5094 148.568;162.134;3.282 506.507;795.183;61.3966 0 0 Exp 2,1(0.34);Hill,1(0.34);Linear,1(0.34) 2.0545138952730304 6.17230749130249 1.9080781936645508 2.162810802459717 0.13293995484574608 2.1014184951782227 13.872716489312864 326.0068835106872 5.0135248385234235 204.30914182814325 36.050365614228554 872.6740343857715 UP 1.0 0.0 0.0 GO:0006959 4 humoral immune response 62 73 4 4 4 4 4 4 55 69 2419 0.97466 0.086685 0.086685 5.48 294228;245920;24232;298566 rt1-s3;cxcl10;c3;c1qa RT1-S3_9763;CXCL10_8408;C3_8175;C1QA_8167 244.01425 243.831 144.319 83.99255244514242 250.97361537627415 75.79154529882149 137.1769 151.6445 57.6936 56.2603822611732 144.89791253524183 48.09829404069481 869.35825 635.7515 153.26 830.2372631669315 892.9150065061812 789.7252142717016 2.5 306.2655 219.207;344.076;144.319;268.455 141.536;187.725;57.6936;161.753 484.566;2052.67;153.26;786.937 2 2 2 24232;298566 C3_8175;C1QA_8167 206.387 206.387 87.7774073893732 109.7233 109.7233 73.5811073862034 470.0985 470.0985 448.07730378194793 144.319;268.455 57.6936;161.753 153.26;786.937 2 294228;245920 RT1-S3_9763;CXCL10_8408 281.6415 281.6415 88.29571665998316 164.63049999999998 164.63049999999998 32.66055511622566 1268.618 1268.618 1108.81697200575 219.207;344.076 141.536;187.725 484.566;2052.67 0 Exp 5,1(0.25);Linear,3(0.75) 1.9794830823600162 7.998668193817139 1.7257766723632812 2.470346212387085 0.33808410906385733 1.9012726545333862 161.70154860376041 326.32695139623956 82.04172538405024 192.31207461594974 55.725732096407 1682.9907679035928 CONFLICT 0.5 0.5 0.0 GO:0006814 8 sodium ion transport 24 25 3 3 3 3 3 3 56 22 2466 0.99772 0.018909 0.018909 12.0 79212;84487;84488 slc6a1;slc17a6;fgf13 SLC6A1_32594;SLC17A6_32912;FGF13_32529 241.612 209.76 145.445 115.43722569864535 246.97992134264322 121.45484500645291 132.74866666666665 130.074 104.722 29.455218168150378 133.486429713132 31.137049438795202 390.824 452.105 237.101 134.0366462091618 381.47137772356353 135.00771121753962 0.5 177.6025 1.5 289.6955 145.445;369.631;209.76 104.722;163.45;130.074 237.101;452.105;483.266 2 1 2 79212;84487 SLC6A1_32594;SLC17A6_32912 257.538 257.538 158.52344084708727 134.08599999999998 134.08599999999998 41.52696704552355 344.603 344.603 152.03078638223252 145.445;369.631 104.722;163.45 237.101;452.105 1 84488 FGF13_32529 209.76 209.76 130.074 130.074 483.266 483.266 209.76 130.074 483.266 0 Exp 2,1(0.34);Hill,1(0.34);Linear,1(0.34) 1.8393628056329934 5.534022927284241 1.6639630794525146 2.0017645359039307 0.17013500470597942 1.8682953119277954 110.98248187003162 372.24151812996837 99.41694951536198 166.08038381797132 239.14725621053702 542.5007437894631 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0098761 7 cellular response to interleukin-7 4 6 1 1 1 1 1 1 58 5 2483 0.99255 0.1313 0.1313 16.67 361680 lsp1 LSP1_32853 231.535 231.535 231.535 231.535 141.502 141.502 141.502 141.502 580.905 580.905 580.905 580.905 0.0 231.535 0.0 231.535 231.535 141.502 580.905 0 1 0 1 361680 LSP1_32853 231.535 231.535 141.502 141.502 580.905 580.905 231.535 141.502 580.905 0 Exp 2,1(1) 1.7316256761550903 1.7316256761550903 1.7316256761550903 1.7316256761550903 0.0 1.7316256761550903 231.535 231.535 141.502 141.502 580.905 580.905 DOWN 0.0 1.0 0.0 GO:1901654 5 response to ketone 140 154 7 7 7 6 6 6 53 148 2340 0.93778 0.14284 0.16698 3.9 78968;362282;25595;24494;24450;24232 srebf1;pck1;map2;il1b;hmgcs2;c3 SREBF1_32750;PCK1_9439;MAP2_32650;IL1B_8892;HMGCS2_8812;C3_8175 186.50716666666668 165.9885 144.319 51.35480688471788 172.17094923398722 39.79633596003298 116.63893333333334 113.36 57.6936 36.76353574435766 105.54058099383798 34.77986664869059 383.24666666666667 303.72450000000003 153.26 234.88322537692355 315.9178812256204 186.197841551735 177.986;227.854;145.437;153.991;269.456;144.319 117.256;148.568;104.718;109.464;162.134;57.6936 348.781;506.507;237.081;258.668;795.183;153.26 5 1 5 362282;25595;24494;24450;24232 PCK1_9439;MAP2_32650;IL1B_8892;HMGCS2_8812;C3_8175 188.2114 153.991 57.226411326414635 116.51552000000001 109.464 41.10149290660859 390.13980000000004 258.668 261.92803840119905 227.854;145.437;153.991;269.456;144.319 148.568;104.718;109.464;162.134;57.6936 506.507;237.081;258.668;795.183;153.26 1 78968 SREBF1_32750 177.986 177.986 117.256 117.256 348.781 348.781 177.986 117.256 348.781 0 Exp 2,2(0.34);Exp 5,1(0.17);Linear,3(0.5) 2.025565306498643 12.382532238960266 1.5889767408370972 2.8712503910064697 0.4537773805728783 2.0168588161468506 145.41476291580238 227.59957041753097 87.22197812001266 146.055888546654 195.30094323788276 571.1923900954506 UP 0.8333333333333334 0.16666666666666666 0.0 GO:0010033 4 response to organic substance 795 856 32 32 28 24 22 22 37 834 1654 0.77369 0.31669 0.57767 2.57 360243;78968;79212;362282;58827;25595;361680;681410;24503;24494;24450;24408;304729;25315;25311;25086;25279;245920;502902;24232;29650;170924 top2a;srebf1;slc6a1;pck1;mest;map2;lsp1;loc681410;ina;il1b;hmgcs2;grin1;gli2;ephx1;dcc;cyp2e1;cyp24a1;cxcl10;clec7a;c3;adam10;abcc4 TOP2A_10059;SREBF1_32750;SLC6A1_32594;PCK1_9439;MEST_9219;MAP2_32650;LSP1_32853;LOC681410_33126;INA_32322;IL1B_8892;HMGCS2_8812;GRIN1_32381;GLI2_8713;EPHX1_8567;DCC_32537;CYP2E1_8421;CYP24A1_32574;CXCL10_8408;CLEC7A_32927;C3_8175;ADAM10_7983;ABCC4_32768 245.33510909090913 246.425 12.5094 96.4667143810799 249.92070835570968 91.78894064018766 164.17639090909094 157.2445 3.282 78.76110210884498 170.08047330364934 77.57923439281161 651.6605272727273 492.04449999999997 61.3966 615.0422272106296 646.3566436264347 643.1699604503917 203.468;177.986;145.445;227.854;272.228;145.437;231.535;410.591;305.642;153.991;269.456;310.025;273.717;12.5094;248.198;357.376;189.111;344.076;412.985;144.319;316.771;244.652 108.442;117.256;104.722;148.568;198.842;104.718;141.502;326.66;249.176;109.464;162.134;254.954;163.744;3.282;183.659;191.769;127.579;187.725;338.673;57.6936;178.963;152.355 572.253;348.781;237.101;506.507;543.288;237.081;580.905;495.344;459.059;258.668;795.183;447.21;831.582;61.3966;299.409;2610.68;364.247;2052.67;488.745;153.26;1374.01;619.152 15 7 15 79212;362282;58827;25595;681410;24503;24494;24450;24408;25315;25086;25279;502902;24232;170924 SLC6A1_32594;PCK1_9439;MEST_9219;MAP2_32650;LOC681410_33126;INA_32322;IL1B_8892;HMGCS2_8812;GRIN1_32381;EPHX1_8567;CYP2E1_8421;CYP24A1_32574;CLEC7A_32927;C3_8175;ABCC4_32768 240.10809333333333 244.652 111.1198718867632 168.70597333333336 152.355 93.72713638374096 551.7947733333333 459.059 600.6009578416788 145.445;227.854;272.228;145.437;410.591;305.642;153.991;269.456;310.025;12.5094;357.376;189.111;412.985;144.319;244.652 104.722;148.568;198.842;104.718;326.66;249.176;109.464;162.134;254.954;3.282;191.769;127.579;338.673;57.6936;152.355 237.101;506.507;543.288;237.081;495.344;459.059;258.668;795.183;447.21;61.3966;2610.68;364.247;488.745;153.26;619.152 7 360243;78968;361680;304729;25311;245920;29650 TOP2A_10059;SREBF1_32750;LSP1_32853;GLI2_8713;DCC_32537;CXCL10_8408;ADAM10_7983 256.53585714285714 248.198 59.536516742328224 154.47014285714286 163.744 32.44337239678076 865.6585714285715 580.905 635.5510661341742 203.468;177.986;231.535;273.717;248.198;344.076;316.771 108.442;117.256;141.502;163.744;183.659;187.725;178.963 572.253;348.781;580.905;831.582;299.409;2052.67;1374.01 0 Exp 2,7(0.32);Exp 5,1(0.05);Hill,1(0.05);Linear,10(0.46);Poly 2,3(0.14) 1.96429268604194 43.68844294548035 1.5415009260177612 2.8712503910064697 0.3091183038677833 1.9678258895874023 205.02423477429318 285.64598340752497 131.26422106358717 197.08856075459465 394.65073814942485 908.6703163960296 UP 0.6818181818181818 0.3181818181818182 0.0 GO:0046483 4 heterocycle metabolic process 413 462 16 15 12 13 11 11 48 451 2037 0.61967 0.51354 0.86523 2.38 360243;78968;291773;362282;316273;681410;24451;24450;316098;25315;25086 top2a;srebf1;taf4b;pck1;mcm3;loc681410;hmox1;hmgcs2;exosc7;ephx1;cyp2e1 TOP2A_10059;SREBF1_32750;RGD1562997_32695;PCK1_9439;MCM3_9207;LOC681410_33126;HMOX1_8815;HMGCS2_8812;EXOSC7_8580;EPHX1_8567;CYP2E1_8421 212.86345454545454 227.854 12.5094 119.48483078024893 216.0428497940908 106.96323633469517 132.03049090909093 133.518 3.282 86.94906320858728 132.12430394958682 76.04300517811889 673.4369636363637 506.507 61.3966 688.540288434609 703.5353877836434 717.0153449778613 203.468;177.986;279.902;227.854;229.093;410.591;61.2776;269.456;111.985;12.5094;357.376 108.442;117.256;166.045;148.568;133.518;326.66;39.7754;162.134;54.886;3.282;191.769 572.253;348.781;888.462;506.507;614.889;495.344;140.784;795.183;373.527;61.3966;2610.68 7 4 7 362282;681410;24451;24450;316098;25315;25086 PCK1_9439;LOC681410_33126;HMOX1_8815;HMGCS2_8812;EXOSC7_8580;EPHX1_8567;CYP2E1_8421 207.29271428571428 227.854 150.82370487457015 132.4392 148.568 110.8048770208845 711.9173714285714 495.344 872.2775529190038 227.854;410.591;61.2776;269.456;111.985;12.5094;357.376 148.568;326.66;39.7754;162.134;54.886;3.282;191.769 506.507;495.344;140.784;795.183;373.527;61.3966;2610.68 4 360243;78968;291773;316273 TOP2A_10059;SREBF1_32750;RGD1562997_32695;MCM3_9207 222.61224999999996 216.2805 43.520570127814366 131.31525 125.387 25.376207483585958 606.09625 593.571 221.48305629607395 203.468;177.986;279.902;229.093 108.442;117.256;166.045;133.518 572.253;348.781;888.462;614.889 0 Exp 2,4(0.37);Hill,1(0.1);Linear,3(0.28);Poly 2,3(0.28) 1.8435047750333586 20.39121401309967 1.5889767408370972 2.162810802459717 0.2044458924609955 1.8518693447113037 142.25243185446368 283.47447723644535 80.64687815180659 183.4141036663752 266.53565563907864 1080.3382716336487 UP 0.6363636363636364 0.36363636363636365 0.0 GO:0009062 6 fatty acid catabolic process 37 42 3 3 3 3 3 3 56 39 2449 0.98491 0.071664 0.071664 7.14 362282;171142;29740 pck1;ehhadh;eci1 PCK1_9439;EHHADH_8534;ECI1_8520 224.76766666666666 227.854 195.758 27.596244533148536 236.71716101356745 26.48732533882291 145.63366666666667 148.568 130.778 13.627533391385835 151.04966959297687 12.789646572141885 510.48499999999996 506.507 388.001 124.52066532106254 569.7733098563448 122.49643411569869 1.5 239.2725 227.854;250.691;195.758 148.568;157.555;130.778 506.507;636.947;388.001 3 0 3 362282;171142;29740 PCK1_9439;EHHADH_8534;ECI1_8520 224.76766666666666 227.854 27.596244533148536 145.63366666666667 148.568 13.627533391385835 510.48499999999996 506.507 124.52066532106254 227.854;250.691;195.758 148.568;157.555;130.778 506.507;636.947;388.001 0 0 Exp 2,2(0.67);Linear,1(0.34) 1.7440669831500797 5.296174764633179 1.5261523723602295 2.162810802459717 0.3465532759534072 1.6072115898132324 193.53957621538797 255.9957571179454 130.21266092572858 161.05467240760476 369.57660230013823 651.3933976998617 UP 1.0 0.0 0.0 GO:0065008 3 regulation of biological quality 821 880 28 28 24 20 18 18 41 862 1626 0.3045 0.78632 0.58062 2.05 286989;78968;79212;29483;84487;362282;25247;24567;58827;681410;24494;24451;24408;84488;245920;502902;24232;29650 ugt2b7;srebf1;slc6a1;slc1a3;slc17a6;pck1;nsg1;mt1;mest;loc681410;il1b;hmox1;grin1;fgf13;cxcl10;clec7a;c3;adam10 UGT2B7_33032;SREBF1_32750;SLC6A1_32594;SLC1A3_32817;SLC17A6_32912;PCK1_9439;NSG1_32675;MT1A_9255;MEST_9219;LOC681410_33126;IL1B_8892;HMOX1_8815;GRIN1_32381;FGF13_32529;CXCL10_8408;CLEC7A_32927;C3_8175;ADAM10_7983 248.541015 250.041 4.13867 119.57474572810216 252.1697494628018 122.9775136807307 162.50159333333335 164.8435 1.39768 88.55770798611078 160.37008978590282 88.56669677565215 885.7838111111112 467.68550000000005 16.5686 1509.6168434213894 883.3846995087493 1536.15555318662 4.13867;177.986;145.445;303.435;369.631;227.854;216.472;392.753;272.228;410.591;153.991;61.2776;310.025;209.76;344.076;412.985;144.319;316.771 1.39768;117.256;104.722;189.179;163.45;148.568;166.237;211.395;198.842;326.66;109.464;39.7754;254.954;130.074;187.725;338.673;57.6936;178.963 16.5686;348.781;237.101;992.735;452.105;506.507;342.576;6610.49;543.288;495.344;258.668;140.784;447.21;483.266;2052.67;488.745;153.26;1374.01 14 4 14 286989;79212;29483;84487;362282;25247;24567;58827;681410;24494;24451;24408;502902;24232 UGT2B7_33032;SLC6A1_32594;SLC1A3_32817;SLC17A6_32912;PCK1_9439;NSG1_32675;MT1A_9255;MEST_9219;LOC681410_33126;IL1B_8892;HMOX1_8815;GRIN1_32381;CLEC7A_32927;C3_8175 244.65323357142856 250.041 130.85287909320294 165.07219142857144 164.8435 99.70090950170348 834.6701142857144 449.6575 1679.1727335947025 4.13867;145.445;303.435;369.631;227.854;216.472;392.753;272.228;410.591;153.991;61.2776;310.025;412.985;144.319 1.39768;104.722;189.179;163.45;148.568;166.237;211.395;198.842;326.66;109.464;39.7754;254.954;338.673;57.6936 16.5686;237.101;992.735;452.105;506.507;342.576;6610.49;543.288;495.344;258.668;140.784;447.21;488.745;153.26 4 78968;84488;245920;29650 SREBF1_32750;FGF13_32529;CXCL10_8408;ADAM10_7983 262.14825 263.2655 80.67137885840722 153.5045 154.51850000000002 35.03388799909783 1064.68175 928.638 800.49212084083 177.986;209.76;344.076;316.771 117.256;130.074;187.725;178.963 348.781;483.266;2052.67;1374.01 0 Exp 2,8(0.45);Exp 5,1(0.06);Hill,2(0.12);Linear,4(0.23);Poly 2,3(0.17) 2.05032055606152 38.11576211452484 1.5889767408370972 3.570159435272217 0.6034524693998136 1.9149555563926697 193.30030080550785 303.78172919449213 121.59001951569955 203.41316715096713 188.37641055300367 1583.1912116692183 UP 0.7777777777777778 0.2222222222222222 0.0 GO:0008152 2 metabolic process 1361 1509 49 47 41 34 31 31 28 1478 1010 0.17689 0.88333 0.28753 2.05 29142;286989;365377;360243;78968;29483;291773;303872;362282;25247;497009;316273;681410;311024;24494;24451;24450;24408;84488;316098;25315;171142;29740;50549;25086;25279;297594;24232;64564;286921;29650 vnn1;ugt2b7;trim72;top2a;srebf1;slc1a3;taf4b;pigz;pck1;nsg1;naaa;mcm3;loc681410;kif5c;il1b;hmox1;hmgcs2;grin1;fgf13;exosc7;ephx1;ehhadh;eci1;cyp4a1;cyp2e1;cyp24a1;cdca3;c3;bbox1;akr1b8;adam10 VNN1_10157;UGT2B7_33032;TRIM72_33144;TOP2A_10059;SREBF1_32750;SLC1A3_32817;RGD1562997_32695;PIGZ_32744;PCK1_9439;NSG1_32675;NAAA_32484;MCM3_9207;LOC681410_33126;KIF5C_8965;IL1B_8892;HMOX1_8815;HMGCS2_8812;GRIN1_32381;FGF13_32529;EXOSC7_8580;EPHX1_8567;EHHADH_8534;ECI1_8520;CYP4A1_33111;CYP2E1_8421;CYP24A1_32574;CDCA3_8260;C3_8175;BBOX1_8133;AKR1B8_8013;ADAM10_7983 226.63637 227.854 4.13867 108.89701164253704 215.36762618374988 98.52599816881785 143.9484283870968 147.819 1.39768 73.94583985397533 137.5397619352832 67.03807819269836 653.0608774193547 459.59 16.5686 776.2886297348784 602.371740012921 758.1008001966172 233.741;4.13867;82.0928;203.468;177.986;303.435;279.902;355.097;227.854;216.472;151.002;229.093;410.591;256.817;153.991;61.2776;269.456;310.025;209.76;111.985;12.5094;250.691;195.758;375.605;357.376;189.111;183.234;144.319;454.248;297.921;316.771 147.819;1.39768;49.3056;108.442;117.256;189.179;166.045;212.48;148.568;166.237;107.821;133.518;326.66;208.309;109.464;39.7754;162.134;254.954;130.074;54.886;3.282;157.555;130.778;197.092;191.769;127.579;111.531;57.6936;259.457;212.377;178.963 556.851;16.5686;193.467;572.253;348.781;992.735;888.462;459.59;506.507;342.576;250.969;614.889;495.344;372.239;258.668;140.784;795.183;447.21;483.266;373.527;61.3966;636.947;388.001;3966.72;2610.68;364.247;407.422;153.26;491.171;681.163;1374.01 24 7 24 29142;286989;365377;29483;303872;362282;25247;497009;681410;311024;24494;24451;24450;24408;316098;25315;171142;29740;50549;25086;25279;24232;64564;286921 VNN1_10157;UGT2B7_33032;TRIM72_33144;SLC1A3_32817;PIGZ_32744;PCK1_9439;NSG1_32675;NAAA_32484;LOC681410_33126;KIF5C_8965;IL1B_8892;HMOX1_8815;HMGCS2_8812;GRIN1_32381;EXOSC7_8580;EPHX1_8567;EHHADH_8534;ECI1_8520;CYP4A1_33111;CYP2E1_8421;CYP24A1_32574;C3_8175;BBOX1_8133;AKR1B8_8013 226.06306125 230.7975 121.53173902837767 146.52384500000002 153.06150000000002 83.1030727990576 648.1585083333333 417.6055 867.6109368706769 233.741;4.13867;82.0928;303.435;355.097;227.854;216.472;151.002;410.591;256.817;153.991;61.2776;269.456;310.025;111.985;12.5094;250.691;195.758;375.605;357.376;189.111;144.319;454.248;297.921 147.819;1.39768;49.3056;189.179;212.48;148.568;166.237;107.821;326.66;208.309;109.464;39.7754;162.134;254.954;54.886;3.282;157.555;130.778;197.092;191.769;127.579;57.6936;259.457;212.377 556.851;16.5686;193.467;992.735;459.59;506.507;342.576;250.969;495.344;372.239;258.668;140.784;795.183;447.21;373.527;61.3966;636.947;388.001;3966.72;2610.68;364.247;153.26;491.171;681.163 7 360243;78968;291773;316273;84488;297594;29650 TOP2A_10059;SREBF1_32750;RGD1562997_32695;MCM3_9207;FGF13_32529;CDCA3_8260;ADAM10_7983 228.602 209.76 51.6602320326446 135.11842857142855 130.074 27.36747424015807 669.869 572.253 356.5916765125062 203.468;177.986;279.902;229.093;209.76;183.234;316.771 108.442;117.256;166.045;133.518;130.074;111.531;178.963 572.253;348.781;888.462;614.889;483.266;407.422;1374.01 0 Exp 2,12(0.39);Exp 5,1(0.04);Hill,2(0.07);Linear,10(0.33);Poly 2,5(0.17);Power,1(0.04) 1.9525211939803242 62.11124384403229 1.5261523723602295 3.570159435272217 0.513889504326768 1.8518693447113037 188.30174789489274 264.97099210510737 117.91754118192702 169.97931559226643 379.78679196452606 926.3349628741836 UP 0.7741935483870968 0.22580645161290322 0.0 GO:0071247 6 cellular response to chromate 2 2 1 1 1 1 1 1 58 1 2487 0.99947 0.045801 0.045801 50.0 24567 mt1 MT1A_9255 392.753 392.753 392.753 392.753 211.395 211.395 211.395 211.395 6610.49 6610.49 6610.49 6610.49 0.0 392.753 0.0 392.753 392.753 211.395 6610.49 1 0 1 24567 MT1A_9255 392.753 392.753 211.395 211.395 6610.49 6610.49 392.753 211.395 6610.49 0 0 Exp 2,1(1) 1.912996768951416 1.912996768951416 1.912996768951416 1.912996768951416 0.0 1.912996768951416 392.753 392.753 211.395 211.395 6610.49 6610.49 UP 1.0 0.0 0.0 GO:0016310 6 phosphorylation 244 262 6 5 5 4 4 4 55 258 2230 0.25813 0.87185 0.51459 1.53 362282;24494;84488;29650 pck1;il1b;fgf13;adam10 PCK1_9439;IL1B_8892;FGF13_32529;ADAM10_7983 227.094 218.80700000000002 153.991 67.54519004340733 199.89075870738742 51.603416025750214 141.76725 139.32100000000003 109.464 29.495796733037576 128.42846017895437 22.549276130371254 655.61275 494.8865 258.668 491.7979497987462 475.29378828662277 331.34325591757704 227.854;153.991;209.76;316.771 148.568;109.464;130.074;178.963 506.507;258.668;483.266;1374.01 2 2 2 362282;24494 PCK1_9439;IL1B_8892 190.9225 190.9225 52.22902817878198 129.01600000000002 129.01600000000002 27.650703571518648 382.5875 382.5875 175.24863754249296 227.854;153.991 148.568;109.464 506.507;258.668 2 84488;29650 FGF13_32529;ADAM10_7983 263.2655 263.2655 75.66820376155377 154.51850000000002 154.51850000000002 34.56974342542905 928.638 928.638 629.8511227012301 209.76;316.771 130.074;178.963 483.266;1374.01 0 Exp 2,2(0.5);Linear,2(0.5) 2.030017883771438 8.341510891914368 1.6434866189956665 2.8712503910064697 0.5763244982093116 1.9133869409561157 160.89971375746094 293.28828624253913 112.86136920162326 170.67313079837677 173.65075919722875 1137.5747408027712 CONFLICT 0.5 0.5 0.0 GO:0007166 5 cell surface receptor signaling pathway 368 386 17 17 14 15 12 12 47 374 2114 0.90069 0.17197 0.26925 3.11 246118;313506;78968;24494;24416;24408;304729;316137;25311;245920;24232;29650 tubb3;stil;srebf1;il1b;grm3;grin1;gli2;adgre1;dcc;cxcl10;c3;adam10 TUBB3_32820;STIL_33274;SREBF1_32750;IL1B_8892;GRM3_33234;GRIN1_32381;GLI2_8713;EMR1_8558;DCC_32537;CXCL10_8408;C3_8175;ADAM10_7983 247.42025 277.995 119.065 77.64853349797644 256.11409987431114 70.38361698593023 166.65814166666664 178.1025 57.6936 62.638113838380676 179.5091705066228 62.13779839983731 662.3067500000001 358.96000000000004 153.26 601.0461886656276 637.9748939701569 608.2684964457525 282.273;311.636;177.986;153.991;286.986;310.025;273.717;119.065;248.198;344.076;144.319;316.771 238.208;177.242;117.256;109.464;241.819;254.954;163.744;89.1701;183.659;187.725;57.6936;178.963 354.06;1285.89;348.781;258.668;363.86;447.21;831.582;178.281;299.409;2052.67;153.26;1374.01 6 6 6 246118;24494;24416;24408;316137;24232 TUBB3_32820;IL1B_8892;GRM3_33234;GRIN1_32381;EMR1_8558;C3_8175 216.10983333333334 218.132 85.6170859546543 165.21811666666667 173.836 89.10790223396384 292.55649999999997 306.36400000000003 115.23489916817738 282.273;153.991;286.986;310.025;119.065;144.319 238.208;109.464;241.819;254.954;89.1701;57.6936 354.06;258.668;363.86;447.21;178.281;153.26 6 313506;78968;304729;25311;245920;29650 STIL_33274;SREBF1_32750;GLI2_8713;DCC_32537;CXCL10_8408;ADAM10_7983 278.73066666666665 292.67650000000003 59.84431294506332 168.09816666666666 178.1025 26.20263761850455 1032.057 1058.736 673.3265703315144 311.636;177.986;273.717;248.198;344.076;316.771 177.242;117.256;163.744;183.659;187.725;178.963 1285.89;348.781;831.582;299.409;2052.67;1374.01 0 Exp 2,4(0.34);Exp 5,1(0.09);Linear,6(0.5);Poly 2,1(0.09) 2.1915932736535706 27.285354733467102 1.5889767408370972 3.667783737182617 0.6675032502830774 2.0660314559936523 203.48645631710838 291.35404368289164 131.21729241826964 202.09899091506375 322.2328547549312 1002.3806452450688 CONFLICT 0.5 0.5 0.0 GO:0045091 8 regulation of single stranded viral RNA replication via double stranded DNA intermediate 1 1 1 1 1 1 1 1 58 0 2488 1.0 0.023165 0.023165 100.0 360243 top2a TOP2A_10059 203.468 203.468 203.468 203.468 108.442 108.442 108.442 108.442 572.253 572.253 572.253 572.253 0.0 203.468 0.0 203.468 203.468 108.442 572.253 0 1 0 1 360243 TOP2A_10059 203.468 203.468 108.442 108.442 572.253 572.253 203.468 108.442 572.253 0 Exp 2,1(1) 2.0807507038116455 2.0807507038116455 2.0807507038116455 2.0807507038116455 0.0 2.0807507038116455 203.468 203.468 108.442 108.442 572.253 572.253 DOWN 0.0 1.0 0.0 GO:0045870 8 positive regulation of single stranded viral RNA replication via double stranded DNA intermediate 1 1 1 1 1 1 1 1 58 0 2488 1.0 0.023165 0.023165 100.0 360243 top2a TOP2A_10059 203.468 203.468 203.468 203.468 108.442 108.442 108.442 108.442 572.253 572.253 572.253 572.253 0.0 203.468 0.0 203.468 203.468 108.442 572.253 0 1 0 1 360243 TOP2A_10059 203.468 203.468 108.442 108.442 572.253 572.253 203.468 108.442 572.253 0 Exp 2,1(1) 2.0807507038116455 2.0807507038116455 2.0807507038116455 2.0807507038116455 0.0 2.0807507038116455 203.468 203.468 108.442 108.442 572.253 572.253 DOWN 0.0 1.0 0.0 GO:0031325 6 positive regulation of cellular metabolic process 693 746 22 22 19 15 14 14 45 732 1756 0.21251 0.86414 0.38751 1.88 360243;313506;78968;291773;362282;25247;24494;24451;24408;304729;84488;25311;502902;24232 top2a;stil;srebf1;taf4b;pck1;nsg1;il1b;hmox1;grin1;gli2;fgf13;dcc;clec7a;c3 TOP2A_10059;STIL_33274;SREBF1_32750;RGD1562997_32695;PCK1_9439;NSG1_32675;IL1B_8892;HMOX1_8815;GRIN1_32381;GLI2_8713;FGF13_32529;DCC_32537;CLEC7A_32927;C3_8175 230.82790000000003 222.163 61.2776 86.32114787191254 236.21849855014298 95.73583327414782 154.41621428571426 156.156 39.7754 75.66945860958359 161.13779267880736 85.36909916880848 503.38521428571437 465.238 140.784 314.0505196062419 489.7774767471027 320.3782594688723 203.468;311.636;177.986;279.902;227.854;216.472;153.991;61.2776;310.025;273.717;209.76;248.198;412.985;144.319 108.442;177.242;117.256;166.045;148.568;166.237;109.464;39.7754;254.954;163.744;130.074;183.659;338.673;57.6936 572.253;1285.89;348.781;888.462;506.507;342.576;258.668;140.784;447.21;831.582;483.266;299.409;488.745;153.26 7 7 7 362282;25247;24494;24451;24408;502902;24232 PCK1_9439;NSG1_32675;IL1B_8892;HMOX1_8815;GRIN1_32381;CLEC7A_32927;C3_8175 218.13194285714286 216.472 115.95618252263593 159.33785714285713 148.568 106.91216490494828 333.9642857142857 342.576 153.98539081215276 227.854;216.472;153.991;61.2776;310.025;412.985;144.319 148.568;166.237;109.464;39.7754;254.954;338.673;57.6936 506.507;342.576;258.668;140.784;447.21;488.745;153.26 7 360243;313506;78968;291773;304729;84488;25311 TOP2A_10059;STIL_33274;SREBF1_32750;RGD1562997_32695;GLI2_8713;FGF13_32529;DCC_32537 243.52385714285714 248.198 48.19368428341558 149.49457142857142 163.744 30.320203868362224 672.8061428571428 572.253 350.7238128049993 203.468;311.636;177.986;279.902;273.717;209.76;248.198 108.442;177.242;117.256;166.045;163.744;130.074;183.659 572.253;1285.89;348.781;888.462;831.582;483.266;299.409 0 Exp 2,6(0.43);Exp 5,1(0.08);Linear,4(0.29);Poly 2,3(0.22) 1.985390439452463 28.544750690460205 1.5889767408370972 3.437419891357422 0.532438998894762 1.9254007935523987 185.61011752023532 276.0456824797647 114.77812785935164 194.05430071207695 338.8754917750298 667.8949367963988 CONFLICT 0.5 0.5 0.0 GO:0006139 4 nucleobase-containing compound metabolic process 359 401 13 12 9 10 8 8 51 393 2095 0.40216 0.7333 0.85607 2.0 360243;78968;291773;362282;316273;681410;24450;316098 top2a;srebf1;taf4b;pck1;mcm3;loc681410;hmgcs2;exosc7 TOP2A_10059;SREBF1_32750;RGD1562997_32695;PCK1_9439;MCM3_9207;LOC681410_33126;HMGCS2_8812;EXOSC7_8580 238.791875 228.4735 111.985 87.32868102165592 231.14005151969982 77.17632989737078 152.188625 141.043 54.886 79.00698684282386 144.93594851782365 70.22970592587285 574.36825 539.38 348.781 189.41158490497423 556.2664032270169 162.56960385497692 203.468;177.986;279.902;227.854;229.093;410.591;269.456;111.985 108.442;117.256;166.045;148.568;133.518;326.66;162.134;54.886 572.253;348.781;888.462;506.507;614.889;495.344;795.183;373.527 4 4 4 362282;681410;24450;316098 PCK1_9439;LOC681410_33126;HMGCS2_8812;EXOSC7_8580 254.97150000000002 248.65500000000003 123.29872601261268 173.062 155.351 112.95617114615739 542.6402499999999 500.9255 178.81058779497212 227.854;410.591;269.456;111.985 148.568;326.66;162.134;54.886 506.507;495.344;795.183;373.527 4 360243;78968;291773;316273 TOP2A_10059;SREBF1_32750;RGD1562997_32695;MCM3_9207 222.61224999999996 216.2805 43.520570127814366 131.31525 125.387 25.376207483585958 606.09625 593.571 221.48305629607395 203.468;177.986;279.902;229.093 108.442;117.256;166.045;133.518 572.253;348.781;888.462;614.889 0 Exp 2,4(0.5);Linear,2(0.25);Poly 2,2(0.25) 1.8514573759085518 14.888501405715942 1.5889767408370972 2.162810802459717 0.20209224239153928 1.8799737691879272 178.2761865083599 299.3075634916401 97.43957636547646 206.93767363452355 443.11271820083317 705.6237817991669 CONFLICT 0.5 0.5 0.0 GO:0050806 6 positive regulation of synaptic transmission 48 51 3 3 2 3 2 2 57 49 2439 0.88741 0.33198 0.33198 3.92 29483;24408 slc1a3;grin1 SLC1A3_32817;GRIN1_32381 306.73 306.73 303.435 4.659833688014132 306.9552852926709 4.648929239488938 222.06650000000002 222.06650000000002 189.179 46.50994853254512 224.31507968519432 46.4011108843168 719.9725 719.9725 447.21 385.74442680679135 701.3232193802263 384.8417486152325 303.435;310.025 189.179;254.954 992.735;447.21 2 0 2 29483;24408 SLC1A3_32817;GRIN1_32381 306.73 306.73 4.659833688014132 222.06650000000002 222.06650000000002 46.50994853254512 719.9725 719.9725 385.74442680679135 303.435;310.025 189.179;254.954 992.735;447.21 0 0 Exp 2,2(1) 1.7925598515627919 3.593186855316162 1.6762725114822388 1.9169143438339233 0.17015947149303248 1.796593427658081 300.27180000000004 313.1882 157.60700000000003 286.526 185.35799999999995 1254.587 UP 1.0 0.0 0.0 GO:0015813 6 L-glutamate transmembrane transport 5 5 2 2 2 2 2 2 57 3 2485 0.99989 0.0050446 0.0050446 40.0 29483;84487 slc1a3;slc17a6 SLC1A3_32817;SLC17A6_32912 336.533 336.533 303.435 46.807640487424074 350.068630831643 42.714501097155974 176.3145 176.3145 163.45 18.19315037314843 171.0534835387736 16.602232744104278 722.4200000000001 722.4200000000001 452.105 382.28313911288285 611.8730168513029 348.854020305691 0.0 303.435 0.0 303.435 303.435;369.631 189.179;163.45 992.735;452.105 2 0 2 29483;84487 SLC1A3_32817;SLC17A6_32912 336.533 336.533 46.807640487424074 176.3145 176.3145 18.19315037314843 722.4200000000001 722.4200000000001 382.28313911288285 303.435;369.631 189.179;163.45 992.735;452.105 0 0 Exp 2,1(0.5);Hill,1(0.5) 1.7696813483550362 3.544567823410034 1.6762725114822388 1.8682953119277954 0.1357806243374843 1.772283911705017 271.66092000000003 401.40508 151.10008 201.52892000000003 192.60260000000005 1252.2374 UP 1.0 0.0 0.0 GO:0009266 4 response to temperature stimulus 80 87 4 4 4 4 4 4 55 83 2405 0.9512 0.1403 0.1403 4.6 24494;24451;24450;245920 il1b;hmox1;hmgcs2;cxcl10 IL1B_8892;HMOX1_8815;HMGCS2_8812;CXCL10_8408 207.20015 211.7235 61.2776 124.81371908390793 209.90625810795524 135.66000361093293 124.77459999999999 135.79899999999998 39.7754 65.36501638623932 124.50585097883896 69.15634942154453 811.8262500000001 526.9255 140.784 874.8813177631104 944.7012048206406 1011.6917382685796 153.991;61.2776;269.456;344.076 109.464;39.7754;162.134;187.725 258.668;140.784;795.183;2052.67 3 1 3 24494;24451;24450 IL1B_8892;HMOX1_8815;HMGCS2_8812 161.57486666666668 153.991 104.2962023846187 103.79113333333332 109.464 61.376239789134495 398.21166666666664 258.668 348.80343888834204 153.991;61.2776;269.456 109.464;39.7754;162.134 258.668;140.784;795.183 1 245920 CXCL10_8408 344.076 344.076 187.725 187.725 2052.67 2052.67 344.076 187.725 2052.67 0 Linear,3(0.75);Poly 2,1(0.25) 2.1546061621143764 8.84205412864685 1.5923793315887451 2.8712503910064697 0.5708599484517523 2.189212203025818 84.8827052977703 329.5175947022297 60.71688394148546 188.83231605851452 -45.55744140784816 1669.2099414078484 UP 0.75 0.25 0.0 GO:0050794 4 regulation of cellular process 1555 1680 54 52 46 39 34 34 25 1646 842 0.11086 0.93207 0.21026 2.02 29142;246118;365377;360243;311715;366669;313506;78968;79212;29483;294228;291773;362282;25247;338475;24567;25595;361680;681410;24494;24451;24416;24408;304729;84488;316137;25311;245920;502902;363198;24232;298566;29650;170924 vnn1;tubb3;trim72;top2a;tcfl5;syne2;stil;srebf1;slc6a1;slc1a3;rt1-s3;taf4b;pck1;nsg1;nrep;mt1;map2;lsp1;loc681410;il1b;hmox1;grm3;grin1;gli2;fgf13;adgre1;dcc;cxcl10;clec7a;cenpq;c3;c1qa;adam10;abcc4 VNN1_10157;TUBB3_32820;TRIM72_33144;TOP2A_10059;TCFL5_9994;SYNE2_9977;STIL_33274;SREBF1_32750;SLC6A1_32594;SLC1A3_32817;RT1-S3_9763;RGD1562997_32695;PCK1_9439;NSG1_32675;NREP_9364;MT1A_9255;MAP2_32650;LSP1_32853;LOC681410_33126;IL1B_8892;HMOX1_8815;GRM3_33234;GRIN1_32381;GLI2_8713;FGF13_32529;EMR1_8558;DCC_32537;CXCL10_8408;CLEC7A_32927;CENPQ_8290;C3_8175;C1QA_8167;ADAM10_7983;ABCC4_32768 237.28767352941173 239.19650000000001 39.9715 91.52463942316415 232.79786708851145 98.39129622630158 158.1518882352941 157.05399999999997 12.1775 72.01156521982809 157.70963198355696 78.7197740595194 736.4066176470587 486.65549999999996 140.784 1112.989997527055 713.5610944590128 1125.2198518879097 233.741;282.273;82.0928;203.468;270.921;276.757;311.636;177.986;145.445;303.435;219.207;279.902;227.854;216.472;222.026;392.753;145.437;231.535;410.591;153.991;61.2776;286.986;310.025;273.717;209.76;119.065;248.198;344.076;412.985;39.9715;144.319;268.455;316.771;244.652 147.819;238.208;49.3056;108.442;228.673;164.88;177.242;117.256;104.722;189.179;141.536;166.045;148.568;166.237;142.777;211.395;104.718;141.502;326.66;109.464;39.7754;241.819;254.954;163.744;130.074;89.1701;183.659;187.725;338.673;12.1775;57.6936;161.753;178.963;152.355 556.851;354.06;193.467;572.253;338.867;858.911;1285.89;348.781;237.101;992.735;484.566;888.462;506.507;342.576;497.741;6610.49;237.081;580.905;495.344;258.668;140.784;363.86;447.21;831.582;483.266;178.281;299.409;2052.67;488.745;177.403;153.26;786.937;1374.01;619.152 20 14 20 29142;246118;365377;311715;79212;29483;362282;25247;24567;25595;681410;24494;24451;24416;24408;316137;502902;24232;298566;170924 VNN1_10157;TUBB3_32820;TRIM72_33144;TCFL5_9994;SLC6A1_32594;SLC1A3_32817;PCK1_9439;NSG1_32675;MT1A_9255;MAP2_32650;LOC681410_33126;IL1B_8892;HMOX1_8815;GRM3_33234;GRIN1_32381;EMR1_8558;CLEC7A_32927;C3_8175;C1QA_8167;ABCC4_32768 235.63851999999997 239.19650000000001 103.45731070293584 168.057085 157.05399999999997 85.73920580658829 715.0988 358.96000000000004 1404.7299425762872 233.741;282.273;82.0928;270.921;145.445;303.435;227.854;216.472;392.753;145.437;410.591;153.991;61.2776;286.986;310.025;119.065;412.985;144.319;268.455;244.652 147.819;238.208;49.3056;228.673;104.722;189.179;148.568;166.237;211.395;104.718;326.66;109.464;39.7754;241.819;254.954;89.1701;338.673;57.6936;161.753;152.355 556.851;354.06;193.467;338.867;237.101;992.735;506.507;342.576;6610.49;237.081;495.344;258.668;140.784;363.86;447.21;178.281;488.745;153.26;786.937;619.152 14 360243;366669;313506;78968;294228;291773;338475;361680;304729;84488;25311;245920;363198;29650 TOP2A_10059;SYNE2_9977;STIL_33274;SREBF1_32750;RT1-S3_9763;RGD1562997_32695;NREP_9364;LSP1_32853;GLI2_8713;FGF13_32529;DCC_32537;CXCL10_8408;CENPQ_8290;ADAM10_7983 239.64360714285718 239.8665 74.90305520064908 144.00160714285715 153.26049999999998 45.309585227282774 766.8463571428572 576.579 508.7338484740035 203.468;276.757;311.636;177.986;219.207;279.902;222.026;231.535;273.717;209.76;248.198;344.076;39.9715;316.771 108.442;164.88;177.242;117.256;141.536;166.045;142.777;141.502;163.744;130.074;183.659;187.725;12.1775;178.963 572.253;858.911;1285.89;348.781;484.566;888.462;497.741;580.905;831.582;483.266;299.409;2052.67;177.403;1374.01 0 Exp 2,12(0.36);Exp 4,1(0.03);Exp 5,1(0.03);Linear,15(0.45);Poly 2,5(0.15) 1.9784856144010772 69.10889148712158 1.5347857475280762 3.667783737182617 0.5292144777222401 1.906087040901184 206.52283504257994 268.0525120162435 133.94612039906204 182.35765607152624 362.2892463338965 1110.5239889602212 CONFLICT 0.5882352941176471 0.4117647058823529 0.0 GO:1902115 6 regulation of organelle assembly 42 45 2 2 2 2 2 2 57 43 2445 0.91558 0.28006 0.28006 4.44 366669;313506 syne2;stil SYNE2_9977;STIL_33274 294.1965 294.1965 276.757 24.663177421006036 296.34865962576055 24.474655020866603 171.06099999999998 171.06099999999998 164.88 8.741254029028616 171.82377981862012 8.674436921011772 1072.4005 1072.4005 858.911 301.91974632425126 1098.7466385030423 299.6119076279456 276.757;311.636 164.88;177.242 858.911;1285.89 0 2 0 2 366669;313506 SYNE2_9977;STIL_33274 294.1965 294.1965 24.663177421006036 171.06099999999998 171.06099999999998 8.741254029028616 1072.4005 1072.4005 301.91974632425126 276.757;311.636 164.88;177.242 858.911;1285.89 0 Linear,2(1) 1.6905670193626627 3.383066773414612 1.6343638896942139 1.748702883720398 0.08084987802996291 1.691533386707306 260.01508 328.37792 158.94624 183.17575999999997 653.9610799999998 1490.8399200000001 DOWN 0.0 1.0 0.0 GO:0033043 6 regulation of organelle organization 271 282 9 9 9 7 7 7 52 275 2213 0.67339 0.48427 0.83303 2.48 360243;366669;313506;78968;25595;24494;84488 top2a;syne2;stil;srebf1;map2;il1b;fgf13 TOP2A_10059;SYNE2_9977;STIL_33274;SREBF1_32750;MAP2_32650;IL1B_8892;FGF13_32529 211.29071428571427 203.468 145.437 62.11242738162872 218.73527624879836 61.10114429749888 130.2965714285714 117.256 104.718 29.257120152521075 134.2319150496671 28.711273532481645 577.8357142857143 483.266 237.081 378.5425235037292 613.1186536475949 388.41302442494066 203.468;276.757;311.636;177.986;145.437;153.991;209.76 108.442;164.88;177.242;117.256;104.718;109.464;130.074 572.253;858.911;1285.89;348.781;237.081;258.668;483.266 2 5 2 25595;24494 MAP2_32650;IL1B_8892 149.714 149.714 6.048591406270443 107.09100000000001 107.09100000000001 3.3559287835111813 247.8745 247.8745 15.264314085473336 145.437;153.991 104.718;109.464 237.081;258.668 5 360243;366669;313506;78968;84488 TOP2A_10059;SYNE2_9977;STIL_33274;SREBF1_32750;FGF13_32529 235.9214 209.76 55.8891748802932 139.5788 130.074 30.069986252075317 709.8202000000001 572.253 372.3859976915081 203.468;276.757;311.636;177.986;209.76 108.442;164.88;177.242;117.256;130.074 572.253;858.911;1285.89;348.781;483.266 0 Exp 2,3(0.43);Linear,4(0.58) 1.919367354686288 13.71364712715149 1.5889767408370972 2.8712503910064697 0.45613779542473065 1.748702883720398 165.2771841557768 257.3042444156518 108.62259350814958 151.97054934899325 297.407488486681 858.2639400847476 DOWN 0.2857142857142857 0.7142857142857143 0.0 GO:0035556 5 intracellular signal transduction 318 334 13 13 11 8 7 7 52 327 2161 0.48168 0.67205 1.0 2.1 24567;24494;24451;24408;84488;316137;245920 mt1;il1b;hmox1;grin1;fgf13;adgre1;cxcl10 MT1A_9255;IL1B_8892;HMOX1_8815;GRIN1_32381;FGF13_32529;EMR1_8558;CXCL10_8408 227.27822857142857 209.76 61.2776 124.37501443872232 238.5326536916315 121.8298887427156 146.0796428571429 130.074 39.7754 75.26645037938785 149.94701534762987 72.30018924085165 1453.052714285714 447.21 140.784 2369.4075571137128 1523.711675319312 2311.3704780394905 392.753;153.991;61.2776;310.025;209.76;119.065;344.076 211.395;109.464;39.7754;254.954;130.074;89.1701;187.725 6610.49;258.668;140.784;447.21;483.266;178.281;2052.67 5 2 5 24567;24494;24451;24408;316137 MT1A_9255;IL1B_8892;HMOX1_8815;GRIN1_32381;EMR1_8558 207.42231999999998 153.991 138.64971333440252 140.95170000000002 109.464 89.25838329215917 1527.0866 258.668 2844.165993245788 392.753;153.991;61.2776;310.025;119.065 211.395;109.464;39.7754;254.954;89.1701 6610.49;258.668;140.784;447.21;178.281 2 84488;245920 FGF13_32529;CXCL10_8408 276.918 276.918 94.97575442185234 158.8995 158.8995 40.76541304218577 1267.968 1267.968 1109.7362108212922 209.76;344.076 130.074;187.725 483.266;2052.67 0 Exp 2,3(0.43);Linear,3(0.43);Poly 2,1(0.15) 2.150764679802874 15.516823887825012 1.5923793315887451 3.0889737606048584 0.5959635923683126 1.9169143438339233 135.13992846724904 319.4165286756081 90.3214761214187 201.83780959286702 -302.2289679046728 3208.3343964761016 UP 0.7142857142857143 0.2857142857142857 0.0 GO:0051656 4 establishment of organelle localization 52 55 5 5 5 4 4 4 55 51 2437 0.99195 0.036821 0.036821 7.27 366669;311024;363198;500545 syne2;kif5c;cenpq;cdca8 SYNE2_9977;KIF5C_8965;CENPQ_8290;CDCA8_33310 256.86087499999996 266.78700000000003 39.9715 169.56855774896044 234.3969116224779 185.16886469321312 152.396625 186.59449999999998 12.1775 96.78503421102441 137.24214907453728 107.60792703111703 470.8365 423.51599999999996 177.403 286.61365248419924 407.8795625312656 264.01729114377036 1.5 266.78700000000003 276.757;256.817;39.9715;453.898 164.88;208.309;12.1775;224.22 858.911;372.239;177.403;474.793 1 3 1 311024 KIF5C_8965 256.817 256.817 208.309 208.309 372.239 372.239 256.817 208.309 372.239 3 366669;363198;500545 SYNE2_9977;CENPQ_8290;CDCA8_33310 256.87550000000005 276.757 207.6782183625668 133.7591666666667 164.88 109.39325917113597 503.70233333333334 474.793 341.6725050122314 276.757;39.9715;453.898 164.88;12.1775;224.22 858.911;177.403;474.793 0 Exp 2,1(0.25);Exp 4,1(0.25);Linear,1(0.25);Power,1(0.25) 1.9846343397435913 7.9857529401779175 1.748702883720398 2.3504738807678223 0.25577036574123774 1.9432880878448486 90.68368840601886 423.0380615939812 57.54729147319608 247.24595852680392 189.95512056548478 751.7178794345152 DOWN 0.25 0.75 0.0 GO:0019439 5 aromatic compound catabolic process 57 68 4 4 4 3 3 3 56 65 2423 0.92945 0.20735 0.20735 4.41 24451;316098;25315 hmox1;exosc7;ephx1 HMOX1_8815;EXOSC7_8580;EPHX1_8567 61.924 61.2776 12.5094 49.74095016744253 69.54761478444527 38.28533219812785 32.6478 39.7754 3.282 26.530081328936788 39.405051459808675 18.86898310770096 191.9025333333333 140.784 61.3966 162.22260936334777 197.389579252081 140.54698801882853 61.2776;111.985;12.5094 39.7754;54.886;3.282 140.784;373.527;61.3966 3 0 3 24451;316098;25315 HMOX1_8815;EXOSC7_8580;EPHX1_8567 61.924 61.2776 49.74095016744253 32.6478 39.7754 26.530081328936788 191.9025333333333 140.784 162.22260936334777 61.2776;111.985;12.5094 39.7754;54.886;3.282 140.784;373.527;61.3966 0 0 Hill,1(0.34);Poly 2,2(0.67) 1.860686207536389 5.618929028511047 1.5923793315887451 2.1014184951782227 0.258496256254671 1.9251312017440796 5.636816100915425 118.21118389908456 2.6261867901067504 62.66941320989326 8.330369651571516 375.4746970150951 UP 1.0 0.0 0.0 GO:0048814 8 regulation of dendrite morphogenesis 21 23 2 2 2 2 2 2 57 21 2467 0.98496 0.097858 0.097858 8.7 24408;29650 grin1;adam10 GRIN1_32381;ADAM10_7983 313.398 313.398 310.025 4.770142345881488 311.3771800110436 3.819271022648394 216.95850000000002 216.95850000000002 178.963 53.73375140914688 239.72223136388735 43.0225651174538 910.61 910.61 447.21 655.3465648036923 632.9794091662064 524.710996708243 0.5 313.398 310.025;316.771 254.954;178.963 447.21;1374.01 1 1 1 24408 GRIN1_32381 310.025 310.025 254.954 254.954 447.21 447.21 310.025 254.954 447.21 1 29650 ADAM10_7983 316.771 316.771 178.963 178.963 1374.01 1374.01 316.771 178.963 1374.01 0 Exp 2,1(0.5);Linear,1(0.5) 1.7749431184834943 3.56040096282959 1.6434866189956665 1.9169143438339233 0.1933425983975408 1.780200481414795 306.78692 320.00908000000004 142.48732 291.42968 2.3460000000000036 1818.8739999999998 CONFLICT 0.5 0.5 0.0 GO:0032870 5 cellular response to hormone stimulus 198 212 9 9 7 5 4 4 55 208 2280 0.44736 0.73749 0.81458 1.89 78968;362282;24450;25315 srebf1;pck1;hmgcs2;ephx1 SREBF1_32750;PCK1_9439;HMGCS2_8812;EPHX1_8567 171.95135 202.92000000000002 12.5094 112.68010097775331 180.96387129375225 83.15640633463295 107.81 132.912 3.282 72.17488307345337 115.81783275594312 53.01507647121318 427.9669 427.644 61.3966 306.40953151412674 413.23889731214905 239.471216071296 177.986;227.854;269.456;12.5094 117.256;148.568;162.134;3.282 348.781;506.507;795.183;61.3966 3 1 3 362282;24450;25315 PCK1_9439;HMGCS2_8812;EPHX1_8567 169.93980000000002 227.854 137.91638674979853 104.66133333333335 148.568 88.05870774280834 454.36220000000003 506.507 369.66191355280296 227.854;269.456;12.5094 148.568;162.134;3.282 506.507;795.183;61.3966 1 78968 SREBF1_32750 177.986 177.986 117.256 117.256 348.781 348.781 177.986 117.256 348.781 0 Exp 2,2(0.5);Hill,1(0.25);Linear,1(0.25) 1.9266871336275337 7.761284232139587 1.5889767408370972 2.162810802459717 0.2581578988128274 2.0047483444213867 61.52485104180181 282.3778489581982 37.0786145880157 178.54138541198432 127.68555911615573 728.2482408838443 UP 0.75 0.25 0.0 GO:0098662 7 inorganic cation transmembrane transport 77 78 3 3 3 3 3 3 56 75 2413 0.89553 0.26964 0.42584 3.85 79212;29483;24408 slc6a1;slc1a3;grin1 SLC6A1_32594;SLC1A3_32817;GRIN1_32381 252.96833333333333 303.435 145.445 93.17621710143278 223.53070986920335 98.89002772884338 182.95166666666668 189.179 104.722 75.30935012555435 162.54191224732463 78.34722753274075 559.0153333333333 447.21 237.101 390.0269348523681 461.5394713436386 366.64404471316703 145.445;303.435;310.025 104.722;189.179;254.954 237.101;992.735;447.21 3 0 3 79212;29483;24408 SLC6A1_32594;SLC1A3_32817;GRIN1_32381 252.96833333333333 303.435 93.17621710143278 182.95166666666668 189.179 75.30935012555435 559.0153333333333 447.21 390.0269348523681 145.445;303.435;310.025 104.722;189.179;254.954 237.101;992.735;447.21 0 0 Exp 2,2(0.67);Linear,1(0.34) 1.8597451740350772 5.594951391220093 1.6762725114822388 2.0017645359039307 0.16884564180241898 1.9169143438339233 147.5295178431902 358.40714882347646 97.73111447439689 268.1722188589365 117.65830791002344 1000.372358756643 UP 1.0 0.0 0.0 GO:0031326 6 regulation of cellular biosynthetic process 611 656 20 20 17 14 12 12 47 644 1844 0.21075 0.86875 0.37031 1.83 360243;311715;78968;291773;362282;24494;24451;24408;304729;25311;502902;24232 top2a;tcfl5;srebf1;taf4b;pck1;il1b;hmox1;grin1;gli2;dcc;clec7a;c3 TOP2A_10059;TCFL5_9994;SREBF1_32750;RGD1562997_32695;PCK1_9439;IL1B_8892;HMOX1_8815;GRIN1_32381;GLI2_8713;DCC_32537;CLEC7A_32927;C3_8175 230.3869666666667 238.026 61.2776 91.10067044426815 235.01790435079957 102.58769668649848 159.74558333333331 156.156 39.7754 84.39960352558576 167.2584791592075 94.8010321980669 439.54400000000004 397.9955 140.784 237.7432122212382 409.42759806899323 224.61592703441562 203.468;270.921;177.986;279.902;227.854;153.991;61.2776;310.025;273.717;248.198;412.985;144.319 108.442;228.673;117.256;166.045;148.568;109.464;39.7754;254.954;163.744;183.659;338.673;57.6936 572.253;338.867;348.781;888.462;506.507;258.668;140.784;447.21;831.582;299.409;488.745;153.26 7 5 7 311715;362282;24494;24451;24408;502902;24232 TCFL5_9994;PCK1_9439;IL1B_8892;HMOX1_8815;GRIN1_32381;CLEC7A_32927;C3_8175 225.91037142857144 227.854 117.64028439682431 168.2572857142857 148.568 110.13940896923059 333.4344285714286 338.867 153.95719818925542 270.921;227.854;153.991;61.2776;310.025;412.985;144.319 228.673;148.568;109.464;39.7754;254.954;338.673;57.6936 338.867;506.507;258.668;140.784;447.21;488.745;153.26 5 360243;78968;291773;304729;25311 TOP2A_10059;SREBF1_32750;RGD1562997_32695;GLI2_8713;DCC_32537 236.6542 248.198 44.498775906759526 147.8292 163.744 32.9959955100615 588.0974 572.253 269.4290351767976 203.468;177.986;279.902;273.717;248.198 108.442;117.256;166.045;163.744;183.659 572.253;348.781;888.462;831.582;299.409 0 Exp 2,5(0.42);Exp 5,1(0.09);Linear,3(0.25);Poly 2,3(0.25) 1.944253132736265 23.653661370277405 1.5889767408370972 2.8712503910064697 0.3577622739720847 1.9254007935523987 178.84190999440014 281.93202333893316 111.99201219463859 207.49915447202804 305.0281145775406 574.0598854224595 CONFLICT 0.5833333333333334 0.4166666666666667 0.0 GO:0019369 6 arachidonic acid metabolic process 29 34 4 4 4 3 3 3 56 31 2457 0.99283 0.042498 0.042498 8.82 25315;50549;25086 ephx1;cyp4a1;cyp2e1 EPHX1_8567;CYP4A1_33111;CYP2E1_8421 248.4968 357.376 12.5094 204.57422572093483 324.7660119120829 140.4915046037642 130.71433333333334 191.769 3.282 110.39172643968088 171.85978817902293 75.6976388097951 2212.9321999999997 2610.68 61.3966 1982.8111859051332 2918.724695068898 1500.4165401433434 0.5 184.9427 12.5094;375.605;357.376 3.282;197.092;191.769 61.3966;3966.72;2610.68 3 0 3 25315;50549;25086 EPHX1_8567;CYP4A1_33111;CYP2E1_8421 248.4968 357.376 204.57422572093483 130.71433333333334 191.769 110.39172643968088 2212.9321999999997 2610.68 1982.8111859051332 12.5094;375.605;357.376 3.282;197.092;191.769 61.3966;3966.72;2610.68 0 0 Hill,1(0.34);Linear,2(0.67) 1.818117205807155 5.491344571113586 1.5810112953186035 2.1014184951782227 0.2608710011062397 1.8089147806167603 16.999270793087646 479.9943292069123 5.7943350998690875 255.63433156679758 -30.829880991678237 4456.694280991678 UP 1.0 0.0 0.0 GO:0001889 6 liver development 91 101 4 4 3 4 3 3 56 98 2390 0.79578 0.41718 0.50651 2.97 24451;24450;25315 hmox1;hmgcs2;ephx1 HMOX1_8815;HMGCS2_8812;EPHX1_8567 114.41433333333335 61.2776 12.5094 136.46619777400312 94.32734046982698 106.90676678948755 68.39713333333333 39.7754 3.282 83.203919320266 58.05636168237446 64.22492667214121 332.45453333333336 140.784 61.3966 402.6956856206103 255.47691312420872 324.99467215332857 61.2776;269.456;12.5094 39.7754;162.134;3.282 140.784;795.183;61.3966 3 0 3 24451;24450;25315 HMOX1_8815;HMGCS2_8812;EPHX1_8567 114.41433333333335 61.2776 136.46619777400312 68.39713333333333 39.7754 83.203919320266 332.45453333333336 140.784 402.6956856206103 61.2776;269.456;12.5094 39.7754;162.134;3.282 140.784;795.183;61.3966 0 0 Hill,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 1.855175855692459 5.6018760204315186 1.5923793315887451 2.1014184951782227 0.2569588533122346 1.9080781936645508 -40.0117068660733 268.84037353273993 -25.756964892354134 162.55123155902078 -123.23853315600473 788.1475998226713 UP 1.0 0.0 0.0 GO:0043523 7 regulation of neuron apoptotic process 110 113 6 6 5 5 4 4 55 109 2379 0.88185 0.26475 0.33134 3.54 24567;24494;24451;24408 mt1;il1b;hmox1;grin1 MT1A_9255;IL1B_8892;HMOX1_8815;GRIN1_32381 229.51164999999997 232.00799999999998 61.2776 149.59523391903232 226.53539656597098 149.65008316754606 153.89710000000002 160.42950000000002 39.7754 97.49627057571651 151.2296707195364 96.64261085332437 1864.288 352.93899999999996 140.784 3166.6504440972535 1857.019455277137 3166.305505215808 392.753;153.991;61.2776;310.025 211.395;109.464;39.7754;254.954 6610.49;258.668;140.784;447.21 4 0 4 24567;24494;24451;24408 MT1A_9255;IL1B_8892;HMOX1_8815;GRIN1_32381 229.51164999999997 232.00799999999998 149.59523391903232 153.89710000000002 160.42950000000002 97.49627057571651 1864.288 352.93899999999996 3166.6504440972535 392.753;153.991;61.2776;310.025 211.395;109.464;39.7754;254.954 6610.49;258.668;140.784;447.21 0 0 Exp 2,2(0.5);Linear,1(0.25);Poly 2,1(0.25) 2.0235252861377617 8.293540835380554 1.5923793315887451 2.8712503910064697 0.5532218018448619 1.9149555563926697 82.90832075934838 376.1149792406517 58.35075483579776 249.44344516420222 -1239.0294352153082 4967.605435215308 UP 1.0 0.0 0.0 GO:0022414 2 reproductive process 343 368 12 12 10 8 7 7 52 361 2127 0.36467 0.7703 0.70857 1.9 360243;311715;24494;24408;304729;50549;29650 top2a;tcfl5;il1b;grin1;gli2;cyp4a1;adam10 TOP2A_10059;TCFL5_9994;IL1B_8892;GRIN1_32381;GLI2_8713;CYP4A1_33111;ADAM10_7983 272.07114285714283 273.717 153.991 73.94950427696956 265.9935687205683 78.45151257767097 177.33314285714283 178.963 108.442 55.66375568964244 176.3936448639157 58.26019133186211 1112.7585714285713 572.253 258.668 1313.766116376358 1079.9574298427644 1377.8747994984758 203.468;270.921;153.991;310.025;273.717;375.605;316.771 108.442;228.673;109.464;254.954;163.744;197.092;178.963 572.253;338.867;258.668;447.21;831.582;3966.72;1374.01 4 3 4 311715;24494;24408;50549 TCFL5_9994;IL1B_8892;GRIN1_32381;CYP4A1_33111 277.6355 290.47299999999996 93.05938879912487 197.54575 212.8825 63.306696414492166 1252.86625 393.0385 1810.884586682868 270.921;153.991;310.025;375.605 228.673;109.464;254.954;197.092 338.867;258.668;447.21;3966.72 3 360243;304729;29650 TOP2A_10059;GLI2_8713;ADAM10_7983 264.652 273.717 57.19285900355061 150.383 163.744 37.11051200131844 925.9483333333334 831.582 409.1238509453259 203.468;273.717;316.771 108.442;163.744;178.963 572.253;831.582;1374.01 0 Exp 2,3(0.43);Linear,4(0.58) 1.9832049066238981 14.13624656200409 1.5810112953186035 2.8712503910064697 0.4351067823147004 1.9169143438339233 217.28858344699972 326.85370226728605 136.09685557064077 218.56943014364495 139.5070124747757 2086.010130382367 CONFLICT 0.5714285714285714 0.42857142857142855 0.0 GO:0008284 6 positive regulation of cell population proliferation 272 293 12 12 10 10 9 9 50 284 2204 0.86712 0.23181 0.4052 3.07 294228;291773;24494;24451;304729;245920;502902;29650;170924 rt1-s3;taf4b;il1b;hmox1;gli2;cxcl10;clec7a;adam10;abcc4 RT1-S3_9763;RGD1562997_32695;IL1B_8892;HMOX1_8815;GLI2_8713;CXCL10_8408;CLEC7A_32927;ADAM10_7983;ABCC4_32768 256.2865111111111 273.717 61.2776 104.15397041952426 256.9036156236374 109.5065215616863 164.25337777777776 163.744 39.7754 79.3309976801909 169.5412848238669 87.70476540390403 793.1821111111111 619.152 140.784 598.3064177381111 752.8494760068847 640.2320582501377 219.207;279.902;153.991;61.2776;273.717;344.076;412.985;316.771;244.652 141.536;166.045;109.464;39.7754;163.744;187.725;338.673;178.963;152.355 484.566;888.462;258.668;140.784;831.582;2052.67;488.745;1374.01;619.152 4 5 4 24494;24451;502902;170924 IL1B_8892;HMOX1_8815;CLEC7A_32927;ABCC4_32768 218.2264 199.32150000000001 149.8758786951389 160.06685 130.90949999999998 127.7892937866471 376.83725000000004 373.7065 216.7370842432138 153.991;61.2776;412.985;244.652 109.464;39.7754;338.673;152.355 258.668;140.784;488.745;619.152 5 294228;291773;304729;245920;29650 RT1-S3_9763;RGD1562997_32695;GLI2_8713;CXCL10_8408;ADAM10_7983 286.7346 279.902 47.34538143578533 167.6026 166.045 17.541039145387252 1126.258 888.462 607.2004925689702 219.207;279.902;273.717;344.076;316.771 141.536;166.045;163.744;187.725;178.963 484.566;888.462;831.582;2052.67;1374.01 0 Linear,7(0.78);Poly 2,2(0.23) 1.9383439196168095 17.840336799621582 1.5415009260177612 2.8712503910064697 0.46195883154175327 1.7851157188415527 188.239250437022 324.3337717852002 112.42379262671977 216.0829629288358 402.28858485554514 1184.075637366677 CONFLICT 0.4444444444444444 0.5555555555555556 0.0 GO:0120035 7 regulation of plasma membrane bounded cell projection organization 153 165 7 7 7 6 6 6 53 159 2329 0.9164 0.17951 0.27466 3.64 366669;25595;24408;84488;25311;29650 syne2;map2;grin1;fgf13;dcc;adam10 SYNE2_9977;MAP2_32650;GRIN1_32381;FGF13_32529;DCC_32537;ADAM10_7983 251.15800000000002 262.4775 145.437 65.30724937401655 253.41956663677135 48.53245919096855 169.54133333333334 171.92149999999998 104.718 51.70079866952411 176.00001932735427 49.63474993702061 616.6478333333333 465.238 237.081 429.76743585125973 523.5968778923765 296.657643722618 276.757;145.437;310.025;209.76;248.198;316.771 164.88;104.718;254.954;130.074;183.659;178.963 858.911;237.081;447.21;483.266;299.409;1374.01 2 4 2 25595;24408 MAP2_32650;GRIN1_32381 227.731 227.731 116.38129090193146 179.836 179.836 106.23289437834215 342.14549999999997 342.14549999999997 148.58364082394812 145.437;310.025 104.718;254.954 237.081;447.21 4 366669;84488;25311;29650 SYNE2_9977;FGF13_32529;DCC_32537;ADAM10_7983 262.87149999999997 262.4775 45.21838212128644 164.394 171.92149999999998 24.23148490428654 753.8989999999999 671.0885 474.4711277671875 276.757;209.76;248.198;316.771 164.88;130.074;183.659;178.963 858.911;483.266;299.409;1374.01 0 Exp 2,2(0.34);Linear,3(0.5);Poly 2,1(0.17) 1.83101354314724 11.032593607902527 1.6434866189956665 2.1256394386291504 0.1866831791815751 1.8328086137771606 198.9013170927946 303.4146829072054 128.17207849533216 210.91058817133452 272.7622642060365 960.5334024606302 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0008219 3 cell death 158 170 8 8 8 5 5 5 54 165 2323 0.80263 0.35823 0.59213 2.94 25247;24494;24451;84488;25311 nsg1;il1b;hmox1;fgf13;dcc NSG1_32675;IL1B_8892;HMOX1_8815;FGF13_32529;DCC_32537 177.93972 209.76 61.2776 73.51374728982334 179.24920369377668 74.38054719346302 125.84187999999999 130.074 39.7754 56.27648233829119 124.79224014574083 55.951509251221964 304.9406 299.409 140.784 124.83540468472884 310.3428405226569 131.90389857775583 216.472;153.991;61.2776;209.76;248.198 166.237;109.464;39.7754;130.074;183.659 342.576;258.668;140.784;483.266;299.409 3 2 3 25247;24494;24451 NSG1_32675;IL1B_8892;HMOX1_8815 143.91353333333333 153.991 78.08643895487442 105.1588 109.464 63.340627790700026 247.34266666666667 258.668 101.37159462755501 216.472;153.991;61.2776 166.237;109.464;39.7754 342.576;258.668;140.784 2 84488;25311 FGF13_32529;DCC_32537 228.97899999999998 228.97899999999998 27.17977045524866 156.8665 156.8665 37.89031686988112 391.3375 391.3375 130.00653146861526 209.76;248.198 130.074;183.659 483.266;299.409 0 Exp 2,2(0.4);Linear,1(0.2);Poly 2,2(0.4) 2.1917196629362072 11.498899936676025 1.5923793315887451 3.437419891357422 0.8153771062758063 1.933887243270874 113.50207940145197 242.37736059854802 76.51336830314975 175.1703916968503 195.51754325749033 414.3636567425097 UP 0.6 0.4 0.0 GO:0060255 5 regulation of macromolecule metabolic process 1000 1070 31 31 25 22 18 18 41 1052 1436 0.045051 0.97571 0.082397 1.68 360243;311715;313506;78968;294228;291773;362282;25247;681410;24494;24451;24408;304729;84488;316098;25311;502902;24232 top2a;tcfl5;stil;srebf1;rt1-s3;taf4b;pck1;nsg1;loc681410;il1b;hmox1;grin1;gli2;fgf13;exosc7;dcc;clec7a;c3 TOP2A_10059;TCFL5_9994;STIL_33274;SREBF1_32750;RT1-S3_9763;RGD1562997_32695;PCK1_9439;NSG1_32675;LOC681410_33126;IL1B_8892;HMOX1_8815;GRIN1_32381;GLI2_8713;FGF13_32529;EXOSC7_8580;DCC_32537;CLEC7A_32927;C3_8175 235.79414444444444 223.53050000000002 61.2776 92.22874117731425 237.8245816698169 93.26914818209096 161.8656666666667 156.156 39.7754 83.55749265700057 163.98831775272114 84.65533056972185 485.53872222222213 465.238 140.784 278.7340865228756 479.85326306458967 282.7635427293929 203.468;270.921;311.636;177.986;219.207;279.902;227.854;216.472;410.591;153.991;61.2776;310.025;273.717;209.76;111.985;248.198;412.985;144.319 108.442;228.673;177.242;117.256;141.536;166.045;148.568;166.237;326.66;109.464;39.7754;254.954;163.744;130.074;54.886;183.659;338.673;57.6936 572.253;338.867;1285.89;348.781;484.566;888.462;506.507;342.576;495.344;258.668;140.784;447.21;831.582;483.266;373.527;299.409;488.745;153.26 10 8 10 311715;362282;25247;681410;24494;24451;24408;316098;502902;24232 TCFL5_9994;PCK1_9439;NSG1_32675;LOC681410_33126;IL1B_8892;HMOX1_8815;GRIN1_32381;EXOSC7_8580;CLEC7A_32927;C3_8175 232.04206 222.163 120.1084929508521 172.5584 157.4025 110.82904276382914 354.54879999999997 358.05150000000003 135.67298853804488 270.921;227.854;216.472;410.591;153.991;61.2776;310.025;111.985;412.985;144.319 228.673;148.568;166.237;326.66;109.464;39.7754;254.954;54.886;338.673;57.6936 338.867;506.507;342.576;495.344;258.668;140.784;447.21;373.527;488.745;153.26 8 360243;313506;78968;294228;291773;304729;84488;25311 TOP2A_10059;STIL_33274;SREBF1_32750;RT1-S3_9763;RGD1562997_32695;GLI2_8713;FGF13_32529;DCC_32537 240.48424999999997 233.7025 45.439415045122104 148.49975 152.64 28.211725215641422 649.276125 528.4095 331.4574341710681 203.468;311.636;177.986;219.207;279.902;273.717;209.76;248.198 108.442;177.242;117.256;141.536;166.045;163.744;130.074;183.659 572.253;1285.89;348.781;484.566;888.462;831.582;483.266;299.409 0 Exp 2,7(0.39);Exp 5,1(0.06);Linear,5(0.28);Poly 2,5(0.28) 1.9475009310918963 35.83231258392334 1.5889767408370972 3.437419891357422 0.4760378848166393 1.8807859420776367 193.18663981734957 278.4016490715394 123.26407447788263 200.46725885545072 356.7701439064889 614.3073005379554 CONFLICT 0.5555555555555556 0.4444444444444444 0.0 GO:0045766 7 positive regulation of angiogenesis 68 69 3 3 3 3 3 3 56 66 2422 0.92636 0.21343 0.21343 4.35 24494;24451;24232 il1b;hmox1;c3 IL1B_8892;HMOX1_8815;C3_8175 119.86253333333333 144.319 61.2776 50.96599558777727 119.9608222886422 51.16308662348397 68.97766666666666 57.6936 39.7754 36.18871181588722 69.92875977796754 36.76674064787199 184.23733333333334 153.26 140.784 64.75998571134289 186.19774039282663 65.71200959638381 153.991;61.2776;144.319 109.464;39.7754;57.6936 258.668;140.784;153.26 3 0 3 24494;24451;24232 IL1B_8892;HMOX1_8815;C3_8175 119.86253333333333 144.319 50.96599558777727 68.97766666666666 57.6936 36.18871181588722 184.23733333333334 153.26 64.75998571134289 153.991;61.2776;144.319 109.464;39.7754;57.6936 258.668;140.784;153.26 0 0 Exp 5,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 1.990829486518983 6.189406394958496 1.5923793315887451 2.8712503910064697 0.7030192123079076 1.7257766723632812 62.18908003997716 177.5359866266895 28.026284149951266 109.92904918338206 110.95451077433948 257.5201558923272 UP 1.0 0.0 0.0 GO:0006955 3 immune response 185 212 11 11 9 9 8 8 51 204 2284 0.9479 0.11243 0.14864 3.77 29142;294228;24584;24494;316137;245920;24232;298566 vnn1;rt1-s3;mylpf;il1b;adgre1;cxcl10;c3;c1qa VNN1_10157;RT1-S3_9763;MYLPF_32295;IL1B_8892;EMR1_8558;CXCL10_8408;C3_8175;C1QA_8167 229.508125 226.474 119.065 88.82309528404924 237.31368916024516 81.20365422522113 136.9535875 144.6775 57.6936 48.82471299456095 141.33091413624163 44.64090456816715 836.0741250000001 520.7085 153.26 830.1737272449901 847.2746369186833 780.4353532593367 233.741;219.207;353.211;153.991;119.065;344.076;144.319;268.455 147.819;141.536;200.468;109.464;89.1701;187.725;57.6936;161.753 556.851;484.566;2217.36;258.668;178.281;2052.67;153.26;786.937 6 2 6 29142;24584;24494;316137;24232;298566 VNN1_10157;MYLPF_32295;IL1B_8892;EMR1_8558;C3_8175;C1QA_8167 212.1303333333333 193.866 89.64703985445738 127.72794999999998 128.6415 52.110572896016045 691.8928333333333 407.7595 786.8832146699831 233.741;353.211;153.991;119.065;144.319;268.455 147.819;200.468;109.464;89.1701;57.6936;161.753 556.851;2217.36;258.668;178.281;153.26;786.937 2 294228;245920 RT1-S3_9763;CXCL10_8408 281.6415 281.6415 88.29571665998316 164.63049999999998 164.63049999999998 32.66055511622566 1268.618 1268.618 1108.81697200575 219.207;344.076 141.536;187.725 484.566;2052.67 0 Exp 2,1(0.13);Exp 5,1(0.13);Linear,6(0.75) 2.128266762417084 17.49045705795288 1.601873517036438 3.0889737606048584 0.5572392890946399 1.973560392856598 167.95686025869657 291.05938974130345 103.11978756501782 170.78738743498218 260.79308234411315 1411.355167655887 UP 0.75 0.25 0.0 GO:0045926 5 negative regulation of growth 66 72 5 5 5 3 3 3 56 69 2419 0.91668 0.23189 0.23189 4.17 24567;25595;84488 mt1;map2;fgf13 MT1A_9255;MAP2_32650;FGF13_32529 249.3166666666667 209.76 145.437 128.31542530940433 276.90235030323737 117.09877720541672 148.729 130.074 104.718 55.73152026456851 160.1882854702315 51.581926200712985 2443.612333333333 483.266 237.081 3610.7206871039384 2894.8499751430763 3693.576644207477 392.753;145.437;209.76 211.395;104.718;130.074 6610.49;237.081;483.266 2 1 2 24567;25595 MT1A_9255;MAP2_32650 269.095 269.095 174.87882069593198 158.0565 158.0565 75.43203009663735 3423.7855 3423.7855 4506.680723175373 392.753;145.437 211.395;104.718 6610.49;237.081 1 84488 FGF13_32529 209.76 209.76 130.074 130.074 483.266 483.266 209.76 130.074 483.266 0 Exp 2,2(0.67);Linear,1(0.34) 1.89139617836367 5.702599287033081 1.6639630794525146 2.1256394386291504 0.231077095394482 1.912996768951416 104.11409379327748 394.5192395400559 85.66284787489252 211.7951521251075 -1642.3027655759643 6529.527432242631 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0046677 4 response to antibiotic 202 218 12 12 9 10 7 7 52 211 2277 0.87336 0.23677 0.34363 3.21 78968;29483;24494;24451;24450;24408;25086 srebf1;slc1a3;il1b;hmox1;hmgcs2;grin1;cyp2e1 SREBF1_32750;SLC1A3_32817;IL1B_8892;HMOX1_8815;HMGCS2_8812;GRIN1_32381;CYP2E1_8421 233.3638 269.456 61.2776 105.2370242576886 221.2257131552126 109.89814763595933 152.0759142857143 162.134 39.7754 69.8532423612874 146.82532481071635 74.37968097718226 799.1487142857142 447.21 140.784 853.5604267071966 736.0124633444963 860.1349135165568 177.986;303.435;153.991;61.2776;269.456;310.025;357.376 117.256;189.179;109.464;39.7754;162.134;254.954;191.769 348.781;992.735;258.668;140.784;795.183;447.21;2610.68 6 1 6 29483;24494;24451;24450;24408;25086 SLC1A3_32817;IL1B_8892;HMOX1_8815;HMGCS2_8812;GRIN1_32381;CYP2E1_8421 242.59343333333334 286.44550000000004 112.13489209522018 157.87923333333333 175.6565 74.64898566977766 874.21 621.1965 909.3685891313817 303.435;153.991;61.2776;269.456;310.025;357.376 189.179;109.464;39.7754;162.134;254.954;191.769 992.735;258.668;140.784;795.183;447.21;2610.68 1 78968 SREBF1_32750 177.986 177.986 117.256 117.256 348.781 348.781 177.986 117.256 348.781 0 Exp 2,3(0.43);Linear,3(0.43);Poly 2,1(0.15) 1.872034382026927 13.362786293029785 1.5889767408370972 2.8712503910064697 0.4458759102699197 1.8089147806167603 155.40312142735166 311.3244785726484 100.3279081690574 203.82392040237116 166.8223012363576 1431.475127335071 UP 0.8571428571428571 0.14285714285714285 0.0 GO:1990791 6 dorsal root ganglion development 2 2 1 1 1 1 1 1 58 1 2487 0.99947 0.045801 0.045801 50.0 246118 tubb3 TUBB3_32820 282.273 282.273 282.273 282.273 238.208 238.208 238.208 238.208 354.06 354.06 354.06 354.06 0.0 282.273 0.0 282.273 282.273 238.208 354.06 1 0 1 246118 TUBB3_32820 282.273 282.273 238.208 238.208 354.06 354.06 282.273 238.208 354.06 0 0 Exp 2,1(1) 2.545419454574585 2.545419454574585 2.545419454574585 2.545419454574585 0.0 2.545419454574585 282.273 282.273 238.208 238.208 354.06 354.06 UP 1.0 0.0 0.0 GO:0007204 11 positive regulation of cytosolic calcium ion concentration 73 76 4 4 4 3 3 3 56 73 2415 0.90284 0.25696 0.25696 3.95 24494;24408;245920 il1b;grin1;cxcl10 IL1B_8892;GRIN1_32381;CXCL10_8408 269.364 310.025 153.991 101.35612708169151 275.83747234762984 101.49440907456022 184.0476666666667 187.725 109.464 72.81467647619766 181.7609674567344 68.1405354581261 919.516 447.21 258.668 985.8577545609712 1058.874782167043 1034.0151640523127 153.991;310.025;344.076 109.464;254.954;187.725 258.668;447.21;2052.67 2 1 2 24494;24408 IL1B_8892;GRIN1_32381 232.00799999999998 232.00799999999998 110.3326994956618 182.209 182.209 102.8769655948308 352.93899999999996 352.93899999999996 133.31932673847408 153.991;310.025 109.464;254.954 258.668;447.21 1 245920 CXCL10_8408 344.076 344.076 187.725 187.725 2052.67 2052.67 344.076 187.725 2052.67 0 Exp 2,1(0.34);Linear,2(0.67) 2.3867697909742582 7.258510947227478 1.9169143438339233 2.8712503910064697 0.4791952080481134 2.470346212387085 154.66874498092025 384.0592550190797 101.65010346026973 266.44522987306357 -196.08707035777525 2035.1190703577754 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0055082 5 cellular chemical homeostasis 190 202 9 9 9 6 6 6 53 196 2292 0.81729 0.32464 0.4649 2.97 362282;24567;24494;24451;24408;245920 pck1;mt1;il1b;hmox1;grin1;cxcl10 PCK1_9439;MT1A_9255;IL1B_8892;HMOX1_8815;GRIN1_32381;CXCL10_8408 248.32943333333333 268.9395 61.2776 125.01142852622183 255.88449735453696 130.96539708034788 158.6469 168.1465 39.7754 76.88163740907187 160.17786739756784 78.51362547996834 1669.3881666666666 476.8585 140.784 2519.292220326528 1833.440871655753 2533.8161493199896 227.854;392.753;153.991;61.2776;310.025;344.076 148.568;211.395;109.464;39.7754;254.954;187.725 506.507;6610.49;258.668;140.784;447.21;2052.67 5 1 5 362282;24567;24494;24451;24408 PCK1_9439;MT1A_9255;IL1B_8892;HMOX1_8815;GRIN1_32381 229.18012 227.854 129.5553938250816 152.83128000000002 148.568 84.46787521591862 1592.7318 447.21 2808.8200592273975 227.854;392.753;153.991;61.2776;310.025 148.568;211.395;109.464;39.7754;254.954 506.507;6610.49;258.668;140.784;447.21 1 245920 CXCL10_8408 344.076 344.076 187.725 187.725 2052.67 2052.67 344.076 187.725 2052.67 0 Exp 2,3(0.5);Linear,2(0.34);Poly 2,1(0.17) 2.1152830171926404 12.926697850227356 1.5923793315887451 2.8712503910064697 0.45701409334655285 2.03986257314682 148.29945744415346 348.35940922251325 97.12877780098029 220.1650221990197 -346.46544790267467 3685.241781236008 UP 0.8333333333333334 0.16666666666666666 0.0 GO:0006575 4 cellular modified amino acid metabolic process 61 71 2 2 2 2 2 2 57 69 2419 0.7743 0.49461 0.67957 2.82 29142;64564 vnn1;bbox1 VNN1_10157;BBOX1_8133 343.9945 343.9945 233.741 155.92199499910197 324.136803235784 153.37213659247527 203.63799999999998 203.63799999999998 147.819 78.93998683810386 193.58447085415182 77.64904780760124 524.011 524.011 491.171 46.442773388332355 529.9257941946229 45.68327504974157 233.741;454.248 147.819;259.457 556.851;491.171 2 0 2 29142;64564 VNN1_10157;BBOX1_8133 343.9945 343.9945 155.92199499910197 203.63799999999998 203.63799999999998 78.93998683810386 524.011 524.011 46.442773388332355 233.741;454.248 147.819;259.457 556.851;491.171 0 0 Linear,1(0.5);Power,1(0.5) 2.3151972049404916 4.7074092626571655 1.929691195487976 2.7777180671691895 0.5996455515942002 2.3537046313285828 127.89764000000002 560.09136 94.23275999999998 313.04323999999997 459.64459999999997 588.3774 UP 1.0 0.0 0.0 GO:0009725 4 response to hormone 388 419 17 17 13 11 9 9 50 410 2078 0.48615 0.65395 1.0 2.15 360243;78968;79212;362282;25595;24494;24450;25315;24232 top2a;srebf1;slc6a1;pck1;map2;il1b;hmgcs2;ephx1;c3 TOP2A_10059;SREBF1_32750;SLC6A1_32594;PCK1_9439;MAP2_32650;IL1B_8892;HMGCS2_8812;EPHX1_8567;C3_8175 164.49615555555556 153.991 12.5094 71.65473960540069 161.95286828171993 45.49242293374198 101.80884444444445 108.442 3.282 47.219436311944456 102.06649017417456 32.47271316252308 352.24784444444447 258.668 61.3966 231.266004944453 308.6150883894636 174.33336816243514 203.468;177.986;145.445;227.854;145.437;153.991;269.456;12.5094;144.319 108.442;117.256;104.722;148.568;104.718;109.464;162.134;3.282;57.6936 572.253;348.781;237.101;506.507;237.081;258.668;795.183;61.3966;153.26 7 2 7 79212;362282;25595;24494;24450;25315;24232 SLC6A1_32594;PCK1_9439;MAP2_32650;IL1B_8892;HMGCS2_8812;EPHX1_8567;C3_8175 157.0016285714286 145.445 80.60320253955409 98.65451428571428 104.722 53.98323716103697 321.3138 237.101 249.25188970279314 145.445;227.854;145.437;153.991;269.456;12.5094;144.319 104.722;148.568;104.718;109.464;162.134;3.282;57.6936 237.101;506.507;237.081;258.668;795.183;61.3966;153.26 2 360243;78968 TOP2A_10059;SREBF1_32750 190.72699999999998 190.72699999999998 18.018494998195845 112.84899999999999 112.84899999999999 6.2324391693785035 460.51700000000005 460.51700000000005 158.0185666053199 203.468;177.986 108.442;117.256 572.253;348.781 0 Exp 2,3(0.34);Exp 5,1(0.12);Hill,1(0.12);Linear,4(0.45) 2.037262588632467 18.566465973854065 1.5889767408370972 2.8712503910064697 0.35970713743320165 2.0807507038116455 117.68172568002711 211.310585431084 70.95881272064074 132.65887616824813 201.1540545474018 503.3416343414871 UP 0.7777777777777778 0.2222222222222222 0.0 GO:0015800 7 acidic amino acid transport 9 9 4 4 4 3 3 3 56 6 2482 0.99997 8.9861E-4 8.9861E-4 33.33 79212;29483;84487 slc6a1;slc1a3;slc17a6 SLC6A1_32594;SLC1A3_32817;SLC17A6_32912 272.837 303.435 145.445 115.18254577842937 267.4047182181717 126.24615835036902 152.45033333333333 163.45 104.722 43.289614370346754 144.25687194271364 41.38010928756698 560.647 452.105 237.101 389.3349583738919 460.4725108341858 324.2362551490301 0.0 145.445 0.0 145.445 145.445;303.435;369.631 104.722;189.179;163.45 237.101;992.735;452.105 3 0 3 79212;29483;84487 SLC6A1_32594;SLC1A3_32817;SLC17A6_32912 272.837 303.435 115.18254577842937 152.45033333333333 163.45 43.289614370346754 560.647 452.105 389.3349583738919 145.445;303.435;369.631 104.722;189.179;163.45 237.101;992.735;452.105 0 0 Exp 2,1(0.34);Hill,1(0.34);Linear,1(0.34) 1.84388732676922 5.546332359313965 1.6762725114822388 2.0017645359039307 0.1636214368605558 1.8682953119277954 142.4956793301996 403.17832066980037 103.46352313405711 201.43714353260955 120.0730196766877 1001.2209803233125 UP 1.0 0.0 0.0 GO:0032940 5 secretion by cell 76 81 3 3 3 2 2 2 57 79 2409 0.71119 0.56645 0.71171 2.47 365377;170924 trim72;abcc4 TRIM72_33144;ABCC4_32768 163.3724 163.3724 82.0928 114.94671266426016 135.64071139041633 108.0493111780088 100.8303 100.8303 49.3056 72.86692953720501 83.25064980361351 68.49453422080755 406.3095 406.3095 193.467 301.0047501493956 333.69002435192465 282.9428972879459 82.0928;244.652 49.3056;152.355 193.467;619.152 2 0 2 365377;170924 TRIM72_33144;ABCC4_32768 163.3724 163.3724 114.94671266426016 100.8303 100.8303 72.86692953720501 406.3095 406.3095 301.0047501493956 82.0928;244.652 49.3056;152.355 193.467;619.152 0 0 Linear,1(0.5);Poly 2,1(0.5) 1.6025966005798342 3.2076146602630615 1.5415009260177612 1.6661137342453003 0.08811456172039167 1.6038073301315308 4.064384000000018 322.6804159999999 -0.1581120000000027 201.818712 -10.861799999999903 823.4808 UP 1.0 0.0 0.0 GO:0048609 3 multicellular organismal reproductive process 128 145 6 6 5 4 4 4 55 141 2347 0.75693 0.43571 0.5762 2.76 311715;24494;24408;29650 tcfl5;il1b;grin1;adam10 TCFL5_9994;IL1B_8892;GRIN1_32381;ADAM10_7983 262.927 290.47299999999996 153.991 75.38424696623727 244.21951965455628 81.54850893277629 193.01350000000002 203.81799999999998 109.464 63.995210708823 189.2375883710542 73.95847620100022 604.68875 393.0385 258.668 518.6669787724264 428.29286852293023 336.7327395799466 270.921;153.991;310.025;316.771 228.673;109.464;254.954;178.963 338.867;258.668;447.21;1374.01 3 1 3 311715;24494;24408 TCFL5_9994;IL1B_8892;GRIN1_32381 244.979 270.921 81.18739318391745 197.697 228.673 77.53366660361166 348.2483333333334 338.867 94.6204444205021 270.921;153.991;310.025 228.673;109.464;254.954 338.867;258.668;447.21 1 29650 ADAM10_7983 316.771 316.771 178.963 178.963 1374.01 1374.01 316.771 178.963 1374.01 0 Exp 2,2(0.5);Linear,2(0.5) 2.0211052239594927 8.27630889415741 1.6434866189956665 2.8712503910064697 0.5471522912486692 1.8807859420776367 189.0504379730874 336.80356202691263 130.29819350535337 255.72880649464662 96.39511080302213 1112.982389196978 UP 0.75 0.25 0.0 GO:0044238 3 primary metabolic process 1157 1278 39 37 32 28 26 26 33 1252 1236 0.20683 0.86025 0.35919 2.03 286989;365377;360243;78968;29483;291773;303872;362282;25247;497009;316273;681410;24494;24451;24450;84488;316098;25315;171142;29740;50549;25086;25279;297594;24232;29650 ugt2b7;trim72;top2a;srebf1;slc1a3;taf4b;pigz;pck1;nsg1;naaa;mcm3;loc681410;il1b;hmox1;hmgcs2;fgf13;exosc7;ephx1;ehhadh;eci1;cyp4a1;cyp2e1;cyp24a1;cdca3;c3;adam10 UGT2B7_33032;TRIM72_33144;TOP2A_10059;SREBF1_32750;SLC1A3_32817;RGD1562997_32695;PIGZ_32744;PCK1_9439;NSG1_32675;NAAA_32484;MCM3_9207;LOC681410_33126;IL1B_8892;HMOX1_8815;HMGCS2_8812;FGF13_32529;EXOSC7_8580;EPHX1_8567;EHHADH_8534;ECI1_8520;CYP4A1_33111;CYP2E1_8421;CYP24A1_32574;CDCA3_8260;C3_8175;ADAM10_7983 210.4990565384616 206.61399999999998 4.13867 106.61753644071608 204.3705752630142 97.70532211170153 129.98020307692306 130.426 1.39768 70.55849253321396 126.20455848546096 62.2817431383988 680.625123076923 433.506 16.5686 846.202734769278 622.5037281058247 809.6932596109235 4.13867;82.0928;203.468;177.986;303.435;279.902;355.097;227.854;216.472;151.002;229.093;410.591;153.991;61.2776;269.456;209.76;111.985;12.5094;250.691;195.758;375.605;357.376;189.111;183.234;144.319;316.771 1.39768;49.3056;108.442;117.256;189.179;166.045;212.48;148.568;166.237;107.821;133.518;326.66;109.464;39.7754;162.134;130.074;54.886;3.282;157.555;130.778;197.092;191.769;127.579;111.531;57.6936;178.963 16.5686;193.467;572.253;348.781;992.735;888.462;459.59;506.507;342.576;250.969;614.889;495.344;258.668;140.784;795.183;483.266;373.527;61.3966;636.947;388.001;3966.72;2610.68;364.247;407.422;153.26;1374.01 19 7 19 286989;365377;29483;303872;362282;25247;497009;681410;24494;24451;24450;316098;25315;171142;29740;50549;25086;25279;24232 UGT2B7_33032;TRIM72_33144;SLC1A3_32817;PIGZ_32744;PCK1_9439;NSG1_32675;NAAA_32484;LOC681410_33126;IL1B_8892;HMOX1_8815;HMGCS2_8812;EXOSC7_8580;EPHX1_8567;EHHADH_8534;ECI1_8520;CYP4A1_33111;CYP2E1_8421;CYP24A1_32574;C3_8175 203.8295510526316 195.758 121.34217453509522 128.08717263157897 130.778 81.55289782526845 684.5879052631578 373.527 975.7453771129464 4.13867;82.0928;303.435;355.097;227.854;216.472;151.002;410.591;153.991;61.2776;269.456;111.985;12.5094;250.691;195.758;375.605;357.376;189.111;144.319 1.39768;49.3056;189.179;212.48;148.568;166.237;107.821;326.66;109.464;39.7754;162.134;54.886;3.282;157.555;130.778;197.092;191.769;127.579;57.6936 16.5686;193.467;992.735;459.59;506.507;342.576;250.969;495.344;258.668;140.784;795.183;373.527;61.3966;636.947;388.001;3966.72;2610.68;364.247;153.26 7 360243;78968;291773;316273;84488;297594;29650 TOP2A_10059;SREBF1_32750;RGD1562997_32695;MCM3_9207;FGF13_32529;CDCA3_8260;ADAM10_7983 228.602 209.76 51.6602320326446 135.11842857142855 130.074 27.36747424015807 669.869 572.253 356.5916765125062 203.468;177.986;279.902;229.093;209.76;183.234;316.771 108.442;117.256;166.045;133.518;130.074;111.531;178.963 572.253;348.781;888.462;614.889;483.266;407.422;1374.01 0 Exp 2,9(0.35);Exp 5,1(0.04);Hill,2(0.08);Linear,9(0.35);Poly 2,5(0.2) 1.9235694988950174 51.403722286224365 1.5261523723602295 3.570159435272217 0.53285032347728 1.8271021842956543 169.51659493643433 251.48151814048867 102.85839171761401 157.1020144362321 355.35526369975025 1005.8949824540958 UP 0.7307692307692307 0.2692307692307692 0.0 GO:0051641 3 cellular localization 308 325 10 10 10 8 8 8 51 317 2171 0.6639 0.4855 0.84308 2.46 366669;313506;25247;311024;24408;84488;363198;500545 syne2;stil;nsg1;kif5c;grin1;fgf13;cenpq;cdca8 SYNE2_9977;STIL_33274;NSG1_32675;KIF5C_8965;GRIN1_32381;FGF13_32529;CENPQ_8290;CDCA8_33310 259.4170625 266.78700000000003 39.9715 117.03766593355364 246.88983042345902 135.76594117540094 167.2616875 171.7395 12.1775 73.8332399682543 154.77521021028264 85.5804082117982 555.2860000000001 461.00149999999996 177.403 352.7168189646921 523.165514710138 353.1574008523399 276.757;311.636;216.472;256.817;310.025;209.76;39.9715;453.898 164.88;177.242;166.237;208.309;254.954;130.074;12.1775;224.22 858.911;1285.89;342.576;372.239;447.21;483.266;177.403;474.793 3 5 3 25247;311024;24408 NSG1_32675;KIF5C_8965;GRIN1_32381 261.1046666666667 256.817 46.923650927153396 209.83333333333334 208.309 44.37813894625732 387.3416666666667 372.239 53.92713968247619 216.472;256.817;310.025 166.237;208.309;254.954 342.576;372.239;447.21 5 366669;313506;84488;363198;500545 SYNE2_9977;STIL_33274;FGF13_32529;CENPQ_8290;CDCA8_33310 258.4045 276.757 151.2178711826086 141.7187 164.88 79.8769940248755 656.0526 483.266 427.101384978204 276.757;311.636;209.76;39.9715;453.898 164.88;177.242;130.074;12.1775;224.22 858.911;1285.89;483.266;177.403;474.793 0 Exp 2,4(0.5);Exp 4,1(0.13);Linear,2(0.25);Power,1(0.13) 2.0207203630117365 16.63841414451599 1.6343638896942139 3.437419891357422 0.5934222002953913 1.9080458283424377 178.31409780885565 340.5200271911443 116.09786253464429 218.4255124653557 310.8657145620879 799.706285437912 DOWN 0.375 0.625 0.0 GO:0009628 3 response to abiotic stimulus 422 443 14 14 12 10 9 9 50 434 2054 0.40902 0.7219 0.86175 2.03 360243;29483;362282;24494;24451;24450;24408;304729;245920 top2a;slc1a3;pck1;il1b;hmox1;hmgcs2;grin1;gli2;cxcl10 TOP2A_10059;SLC1A3_32817;PCK1_9439;IL1B_8892;HMOX1_8815;HMGCS2_8812;GRIN1_32381;GLI2_8713;CXCL10_8408 238.58884444444442 269.456 61.2776 88.43588079347539 241.56163187168838 99.28213528389611 151.55393333333333 162.134 39.7754 61.04266809363758 152.86727470141773 65.72935326011084 733.0657777777777 572.253 140.784 565.3650938150006 824.0800211370471 692.2816167040369 203.468;303.435;227.854;153.991;61.2776;269.456;310.025;273.717;344.076 108.442;189.179;148.568;109.464;39.7754;162.134;254.954;163.744;187.725 572.253;992.735;506.507;258.668;140.784;795.183;447.21;831.582;2052.67 6 3 6 29483;362282;24494;24451;24450;24408 SLC1A3_32817;PCK1_9439;IL1B_8892;HMOX1_8815;HMGCS2_8812;GRIN1_32381 221.00643333333332 248.65500000000003 97.07460223604666 150.67906666666667 155.351 72.78665219521136 523.5145 476.8585 321.46837713265046 303.435;227.854;153.991;61.2776;269.456;310.025 189.179;148.568;109.464;39.7754;162.134;254.954 992.735;506.507;258.668;140.784;795.183;447.21 3 360243;304729;245920 TOP2A_10059;GLI2_8713;CXCL10_8408 273.7536666666667 273.717 70.304007171237 153.30366666666666 163.744 40.65954921458603 1152.1683333333333 831.582 790.5632936788384 203.468;273.717;344.076 108.442;163.744;187.725 572.253;831.582;2052.67 0 Exp 2,4(0.45);Linear,4(0.45);Poly 2,1(0.12) 2.065760593700844 18.876978158950806 1.5923793315887451 2.8712503910064697 0.3958309064796899 2.0807507038116455 180.8107356593739 296.366953229515 111.67272351215678 191.4351431545099 363.6939164853108 1102.4376390702448 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0050766 6 positive regulation of phagocytosis 30 35 4 4 4 3 3 3 56 32 2456 0.99204 0.045736 0.045736 8.57 24494;502902;24232 il1b;clec7a;c3 IL1B_8892;CLEC7A_32927;C3_8175 237.09833333333336 153.991 144.319 152.39906997528993 258.99322162533576 159.14526926960136 168.6102 109.464 57.6936 149.53615127092178 190.49552865263288 154.97462530036435 300.22433333333333 258.668 153.26 171.55973576668075 325.294858579549 175.89031668696242 0.5 149.155 153.991;412.985;144.319 109.464;338.673;57.6936 258.668;488.745;153.26 3 0 3 24494;502902;24232 IL1B_8892;CLEC7A_32927;C3_8175 237.09833333333336 153.991 152.39906997528993 168.6102 109.464 149.53615127092178 300.22433333333333 258.668 171.55973576668075 153.991;412.985;144.319 109.464;338.673;57.6936 258.668;488.745;153.26 0 0 Exp 5,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 2.1831403288960782 6.696882009506226 1.7257766723632812 2.8712503910064697 0.5841083699933265 2.0998549461364746 64.64255094734804 409.5541157193187 -0.6058848921006756 337.82628489210066 106.08621646442464 494.36245020224203 UP 1.0 0.0 0.0 GO:0050830 6 defense response to Gram-positive bacterium 27 33 3 3 2 2 2 2 57 31 2457 0.96062 0.17686 0.17686 6.06 294228;25211 rt1-s3;lyz2 RT1-S3_9763;LYZ2_32611 216.961 216.961 214.715 3.1763236610882317 217.57928720291198 3.0536001489116464 140.536 140.536 139.536 1.4142135623730951 140.81128370565983 1.3595726397656167 474.44849999999997 474.44849999999997 464.331 14.308305717310516 477.2336828920134 13.755476182821011 0.5 216.961 219.207;214.715 141.536;139.536 484.566;464.331 1 1 1 25211 LYZ2_32611 214.715 214.715 139.536 139.536 464.331 464.331 214.715 139.536 464.331 1 294228 RT1-S3_9763 219.207 219.207 141.536 141.536 484.566 484.566 219.207 141.536 484.566 0 Linear,2(1) 1.6699663771470388 3.3473604917526245 1.5622447729110718 1.7851157188415527 0.15759355719690346 1.6736802458763123 212.55884000000003 221.36316 138.576 142.496 454.6182 494.27879999999993 CONFLICT 0.5 0.5 0.0 GO:0044282 4 small molecule catabolic process 107 120 5 5 5 4 4 4 55 116 2372 0.85775 0.30159 0.35766 3.33 362282;171142;29740;25279 pck1;ehhadh;eci1;cyp24a1 PCK1_9439;EHHADH_8534;ECI1_8520;CYP24A1_32574 215.85350000000003 211.806 189.111 28.73240814249048 214.04981149725634 32.86973288463606 141.12 139.673 127.579 14.328265468413617 139.87427002874313 16.105119718997262 473.92550000000006 447.254 364.247 125.23305829133116 471.9133564149464 145.036410726594 227.854;250.691;195.758;189.111 148.568;157.555;130.778;127.579 506.507;636.947;388.001;364.247 4 0 4 362282;171142;29740;25279 PCK1_9439;EHHADH_8534;ECI1_8520;CYP24A1_32574 215.85350000000003 211.806 28.73240814249048 141.12 139.673 14.328265468413617 473.92550000000006 447.254 125.23305829133116 227.854;250.691;195.758;189.111 148.568;157.555;130.778;127.579 506.507;636.947;388.001;364.247 0 0 Exp 2,2(0.5);Linear,2(0.5) 1.8388088189855833 7.45122218132019 1.5261523723602295 2.162810802459717 0.34354625823753693 1.881129503250122 187.6957400203591 244.0112599796409 127.07829984095467 155.16170015904532 351.1971028744952 596.6538971255046 UP 1.0 0.0 0.0 GO:0030001 7 metal ion transport 103 108 5 5 5 5 5 5 54 103 2385 0.96333 0.10227 0.10227 4.63 79212;29483;84487;24408;84488 slc6a1;slc1a3;slc17a6;grin1;fgf13 SLC6A1_32594;SLC1A3_32817;SLC17A6_32912;GRIN1_32381;FGF13_32529 267.65919999999994 303.435 145.445 89.10898511485816 262.2660637497649 100.08490731016066 168.4758 163.45 104.722 58.033622773354494 156.63626302262895 53.883447556712134 522.4834 452.105 237.101 280.50708098424195 462.99319732965586 243.3033523413158 145.445;303.435;369.631;310.025;209.76 104.722;189.179;163.45;254.954;130.074 237.101;992.735;452.105;447.21;483.266 4 1 4 79212;29483;84487;24408 SLC6A1_32594;SLC1A3_32817;SLC17A6_32912;GRIN1_32381 282.134 306.73 95.8666577630964 178.07625000000002 176.3145 62.25815257123622 532.28775 449.6575 322.91091875353186 145.445;303.435;369.631;310.025 104.722;189.179;163.45;254.954 237.101;992.735;452.105;447.21 1 84488 FGF13_32529 209.76 209.76 130.074 130.074 483.266 483.266 209.76 130.074 483.266 0 Exp 2,3(0.6);Hill,1(0.2);Linear,1(0.2) 1.8204967426780418 9.127209782600403 1.6639630794525146 2.0017645359039307 0.14968317439100118 1.8682953119277954 189.5517307358469 345.7666692641531 117.6070868032943 219.34451319670575 276.60810270968517 768.3586972903149 UP 0.8 0.2 0.0 GO:0044057 5 regulation of system process 160 167 5 5 5 3 3 3 56 164 2324 0.45166 0.75521 1.0 1.8 78968;24494;24408 srebf1;il1b;grin1 SREBF1_32750;IL1B_8892;GRIN1_32381 214.00066666666666 177.986 153.991 84.02050017902387 210.90019327062225 83.09175195283427 160.558 117.256 109.464 81.8421189119637 157.74898755426915 80.70246292595304 351.55300000000005 348.781 258.668 94.30156111645216 347.46309587554265 94.47464109548196 177.986;153.991;310.025 117.256;109.464;254.954 348.781;258.668;447.21 2 1 2 24494;24408 IL1B_8892;GRIN1_32381 232.00799999999998 232.00799999999998 110.3326994956618 182.209 182.209 102.8769655948308 352.93899999999996 352.93899999999996 133.31932673847408 153.991;310.025 109.464;254.954 258.668;447.21 1 78968 SREBF1_32750 177.986 177.986 117.256 117.256 348.781 348.781 177.986 117.256 348.781 0 Exp 2,2(0.67);Linear,1(0.34) 2.0602998845557203 6.37714147567749 1.5889767408370972 2.8712503910064697 0.666148891804091 1.9169143438339233 118.92252021088616 309.0788131224472 67.9449240056517 253.17107599434829 244.84073787665204 458.26526212334795 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0048523 5 negative regulation of cellular process 938 999 30 30 27 21 19 19 40 980 1508 0.16303 0.89594 0.2834 1.9 29142;365377;360243;311715;313506;78968;79212;294228;24567;25595;681410;24494;24451;24408;304729;84488;245920;24232;29650 vnn1;trim72;top2a;tcfl5;stil;srebf1;slc6a1;rt1-s3;mt1;map2;loc681410;il1b;hmox1;grin1;gli2;fgf13;cxcl10;c3;adam10 VNN1_10157;TRIM72_33144;TOP2A_10059;TCFL5_9994;STIL_33274;SREBF1_32750;SLC6A1_32594;RT1-S3_9763;MT1A_9255;MAP2_32650;LOC681410_33126;IL1B_8892;HMOX1_8815;GRIN1_32381;GLI2_8713;FGF13_32529;CXCL10_8408;C3_8175;ADAM10_7983 231.95865263157899 219.207 61.2776 99.42552308557032 220.31540416949463 98.9289531685518 149.4821894736842 141.536 39.7754 72.72342736980292 140.05350051128912 67.84445685681776 900.1126842105263 483.266 140.784 1468.16104254809 890.4253054386678 1480.383818313027 233.741;82.0928;203.468;270.921;311.636;177.986;145.445;219.207;392.753;145.437;410.591;153.991;61.2776;310.025;273.717;209.76;344.076;144.319;316.771 147.819;49.3056;108.442;228.673;177.242;117.256;104.722;141.536;211.395;104.718;326.66;109.464;39.7754;254.954;163.744;130.074;187.725;57.6936;178.963 556.851;193.467;572.253;338.867;1285.89;348.781;237.101;484.566;6610.49;237.081;495.344;258.668;140.784;447.21;831.582;483.266;2052.67;153.26;1374.01 11 8 11 29142;365377;311715;79212;24567;25595;681410;24494;24451;24408;24232 VNN1_10157;TRIM72_33144;TCFL5_9994;SLC6A1_32594;MT1A_9255;MAP2_32650;LOC681410_33126;IL1B_8892;HMOX1_8815;GRIN1_32381;C3_8175 213.6903090909091 153.991 119.17673638489559 148.6526909090909 109.464 94.19166310923124 879.0111818181817 258.668 1906.0340712689697 233.741;82.0928;270.921;145.445;392.753;145.437;410.591;153.991;61.2776;310.025;144.319 147.819;49.3056;228.673;104.722;211.395;104.718;326.66;109.464;39.7754;254.954;57.6936 556.851;193.467;338.867;237.101;6610.49;237.081;495.344;258.668;140.784;447.21;153.26 8 360243;313506;78968;294228;304729;84488;245920;29650 TOP2A_10059;STIL_33274;SREBF1_32750;RT1-S3_9763;GLI2_8713;FGF13_32529;CXCL10_8408;ADAM10_7983 257.077625 246.462 62.32188364322188 150.62275 152.64 30.37356516422983 929.12725 701.9175 592.5310922963694 203.468;311.636;177.986;219.207;273.717;209.76;344.076;316.771 108.442;177.242;117.256;141.536;163.744;130.074;187.725;178.963 572.253;1285.89;348.781;484.566;831.582;483.266;2052.67;1374.01 0 Exp 2,6(0.32);Exp 5,1(0.06);Linear,9(0.48);Poly 2,3(0.16) 1.891248983506843 36.3850200176239 1.5889767408370972 2.8712503910064697 0.3300920854607852 1.84465754032135 187.25148511706334 276.6658201460946 116.78174849281763 182.18263045455083 239.94696789850195 1560.2784005225512 CONFLICT 0.5789473684210527 0.42105263157894735 0.0 GO:0048522 5 positive regulation of cellular process 1060 1140 38 37 32 27 24 24 35 1116 1372 0.30802 0.77874 0.59683 2.11 29142;360243;366669;313506;78968;29483;294228;291773;362282;25247;25595;24494;24451;24408;304729;84488;25311;245920;502902;363198;24232;298566;29650;170924 vnn1;top2a;syne2;stil;srebf1;slc1a3;rt1-s3;taf4b;pck1;nsg1;map2;il1b;hmox1;grin1;gli2;fgf13;dcc;cxcl10;clec7a;cenpq;c3;c1qa;adam10;abcc4 VNN1_10157;TOP2A_10059;SYNE2_9977;STIL_33274;SREBF1_32750;SLC1A3_32817;RT1-S3_9763;RGD1562997_32695;PCK1_9439;NSG1_32675;MAP2_32650;IL1B_8892;HMOX1_8815;GRIN1_32381;GLI2_8713;FGF13_32529;DCC_32537;CXCL10_8408;CLEC7A_32927;CENPQ_8290;C3_8175;C1QA_8167;ADAM10_7983;ABCC4_32768 234.33721249999996 239.19650000000001 39.9715 85.87976673778255 232.57290155196182 96.38034832252879 150.12218750000002 157.05399999999997 12.1775 65.93572927431617 149.78880328837053 75.81444701297457 632.8212083333333 497.626 140.784 451.008703051859 626.8111276875211 482.0320184767722 233.741;203.468;276.757;311.636;177.986;303.435;219.207;279.902;227.854;216.472;145.437;153.991;61.2776;310.025;273.717;209.76;248.198;344.076;412.985;39.9715;144.319;268.455;316.771;244.652 147.819;108.442;164.88;177.242;117.256;189.179;141.536;166.045;148.568;166.237;104.718;109.464;39.7754;254.954;163.744;130.074;183.659;187.725;338.673;12.1775;57.6936;161.753;178.963;152.355 556.851;572.253;858.911;1285.89;348.781;992.735;484.566;888.462;506.507;342.576;237.081;258.668;140.784;447.21;831.582;483.266;299.409;2052.67;488.745;177.403;153.26;786.937;1374.01;619.152 12 12 12 29142;29483;362282;25247;25595;24494;24451;24408;502902;24232;298566;170924 VNN1_10157;SLC1A3_32817;PCK1_9439;NSG1_32675;MAP2_32650;IL1B_8892;HMOX1_8815;GRIN1_32381;CLEC7A_32927;C3_8175;C1QA_8167;ABCC4_32768 226.88696666666667 230.7975 93.32043756441202 155.93241666666668 150.4615 81.18620662629193 460.87550000000005 467.97749999999996 257.3557058178426 233.741;303.435;227.854;216.472;145.437;153.991;61.2776;310.025;412.985;144.319;268.455;244.652 147.819;189.179;148.568;166.237;104.718;109.464;39.7754;254.954;338.673;57.6936;161.753;152.355 556.851;992.735;506.507;342.576;237.081;258.668;140.784;447.21;488.745;153.26;786.937;619.152 12 360243;366669;313506;78968;294228;291773;304729;84488;25311;245920;363198;29650 TOP2A_10059;SYNE2_9977;STIL_33274;SREBF1_32750;RT1-S3_9763;RGD1562997_32695;GLI2_8713;FGF13_32529;DCC_32537;CXCL10_8408;CENPQ_8290;ADAM10_7983 241.78745833333335 260.9575 81.18709987807006 144.31195833333334 164.312 49.24849528133194 804.7669166666668 701.9175 542.7442193508931 203.468;276.757;311.636;177.986;219.207;279.902;273.717;209.76;248.198;344.076;39.9715;316.771 108.442;164.88;177.242;117.256;141.536;166.045;163.744;130.074;183.659;187.725;12.1775;178.963 572.253;858.911;1285.89;348.781;484.566;888.462;831.582;483.266;299.409;2052.67;177.403;1374.01 0 Exp 2,7(0.3);Exp 4,1(0.05);Exp 5,1(0.05);Linear,12(0.5);Poly 2,3(0.13) 1.9351923064603282 47.382113099098206 1.5415009260177612 3.437419891357422 0.44205778993738365 1.9080458283424377 199.9781499029877 268.6962750970123 123.74240171840688 176.50197328159317 452.3801469681927 813.2622696984738 CONFLICT 0.5 0.5 0.0 GO:0010605 6 negative regulation of macromolecule metabolic process 531 562 16 16 13 10 8 8 51 554 1934 0.070325 0.96638 0.15104 1.42 311715;78968;681410;24494;24451;304729;316098;24232 tcfl5;srebf1;loc681410;il1b;hmox1;gli2;exosc7;c3 TCFL5_9994;SREBF1_32750;LOC681410_33126;IL1B_8892;HMOX1_8815;GLI2_8713;EXOSC7_8580;C3_8175 200.59844999999996 165.9885 61.2776 111.8047092009354 190.3326320955414 102.64106742797411 137.269 113.36 39.7754 99.08323408061672 126.93386600000002 88.11658601165165 367.60162499999996 343.824 140.784 221.05784934455352 363.47353601910834 240.6055298253148 270.921;177.986;410.591;153.991;61.2776;273.717;111.985;144.319 228.673;117.256;326.66;109.464;39.7754;163.744;54.886;57.6936 338.867;348.781;495.344;258.668;140.784;831.582;373.527;153.26 6 2 6 311715;681410;24494;24451;316098;24232 TCFL5_9994;LOC681410_33126;IL1B_8892;HMOX1_8815;EXOSC7_8580;C3_8175 192.1807666666667 149.155 127.45137221013611 136.192 83.5788 116.28757935662777 293.40833333333336 298.76750000000004 136.67928725109246 270.921;410.591;153.991;61.2776;111.985;144.319 228.673;326.66;109.464;39.7754;54.886;57.6936 338.867;495.344;258.668;140.784;373.527;153.26 2 78968;304729 SREBF1_32750;GLI2_8713 225.8515 225.8515 67.69203926976942 140.5 140.5 32.8719800438003 590.1815 590.1815 341.3918610636464 177.986;273.717 117.256;163.744 348.781;831.582 0 Exp 2,2(0.25);Exp 5,1(0.13);Linear,2(0.25);Poly 2,3(0.38) 1.899640259255783 15.479004979133606 1.5889767408370972 2.8712503910064697 0.42693646071869473 1.7886574864387512 123.12173931632007 278.0751606836799 68.60782181410785 205.93017818589215 214.41635078007303 520.786899219927 UP 0.75 0.25 0.0 GO:0050769 7 positive regulation of neurogenesis 132 142 5 5 5 4 4 4 55 138 2350 0.77002 0.41973 0.56849 2.82 24494;24408;304729;25311 il1b;grin1;gli2;dcc IL1B_8892;GRIN1_32381;GLI2_8713;DCC_32537 246.48274999999998 260.9575 153.991 66.67580222926965 244.51820389700762 64.81534853362537 177.95524999999998 173.7015 109.464 60.150786137146014 176.0207635947907 57.59874153877072 459.21725000000004 373.30949999999996 258.668 261.12472086390056 449.2560334029227 260.1617102481276 153.991;310.025;273.717;248.198 109.464;254.954;163.744;183.659 258.668;447.21;831.582;299.409 2 2 2 24494;24408 IL1B_8892;GRIN1_32381 232.00799999999998 232.00799999999998 110.3326994956618 182.209 182.209 102.8769655948308 352.93899999999996 352.93899999999996 133.31932673847408 153.991;310.025 109.464;254.954 258.668;447.21 2 304729;25311 GLI2_8713;DCC_32537 260.9575 260.9575 18.044657949100255 173.7015 173.7015 14.082031547329832 565.4955 565.4955 376.30313706438864 273.717;248.198 163.744;183.659 831.582;299.409 0 Exp 2,1(0.25);Linear,2(0.5);Poly 2,1(0.25) 2.199337249888076 8.920227646827698 1.9169143438339233 2.8712503910064697 0.4464378388482516 2.0660314559936523 181.14046381531585 311.8250361846841 119.007479585597 236.90302041440302 203.31502355337744 715.1194764466227 CONFLICT 0.5 0.5 0.0 GO:0001505 4 regulation of neurotransmitter levels 102 115 5 5 5 5 5 5 54 110 2378 0.95238 0.12482 0.18823 4.35 79212;29483;84487;24494;502902 slc6a1;slc1a3;slc17a6;il1b;clec7a SLC6A1_32594;SLC1A3_32817;SLC17A6_32912;IL1B_8892;CLEC7A_32927 277.0974 303.435 145.445 122.68772991134837 279.7213519995168 127.143106780702 181.0976 163.45 104.722 95.09384630616226 178.13747465869278 95.99579664392988 485.87080000000003 452.105 237.101 304.78157475346165 436.0018844086022 252.91527263478403 145.445;303.435;369.631;153.991;412.985 104.722;189.179;163.45;109.464;338.673 237.101;992.735;452.105;258.668;488.745 5 0 5 79212;29483;84487;24494;502902 SLC6A1_32594;SLC1A3_32817;SLC17A6_32912;IL1B_8892;CLEC7A_32927 277.0974 303.435 122.68772991134837 181.0976 163.45 95.09384630616226 485.87080000000003 452.105 304.78157475346165 145.445;303.435;369.631;153.991;412.985 104.722;189.179;163.45;109.464;338.673 237.101;992.735;452.105;258.668;488.745 0 0 Exp 2,1(0.2);Hill,1(0.2);Linear,2(0.4);Poly 2,1(0.2) 2.0677246264937486 10.51743769645691 1.6762725114822388 2.8712503910064697 0.457615730013482 2.0017645359039307 169.55686319793148 384.6379368020685 97.74416860366159 264.4510313963384 218.71797078023576 753.0236292197643 UP 1.0 0.0 0.0 GO:0006508 5 proteolysis 170 184 2 2 2 2 2 2 57 182 2306 0.18808 0.93511 0.4388 1.09 365377;29650 trim72;adam10 TRIM72_33144;ADAM10_7983 199.4319 199.4319 82.0928 165.9425466166528 111.22692674418606 109.43808369805407 114.1343 114.1343 49.3056 91.68162677101668 65.40191880984952 60.46346611347827 783.7385 783.7385 193.467 834.7699607823104 340.02551880984953 550.5256288958747 82.0928;316.771 49.3056;178.963 193.467;1374.01 1 1 1 365377 TRIM72_33144 82.0928 82.0928 49.3056 49.3056 193.467 193.467 82.0928 49.3056 193.467 1 29650 ADAM10_7983 316.771 316.771 178.963 178.963 1374.01 1374.01 316.771 178.963 1374.01 0 Linear,1(0.5);Poly 2,1(0.5) 1.6547615018355526 3.309600353240967 1.6434866189956665 1.6661137342453003 0.015999786631705593 1.6548001766204834 -30.55273600000001 429.41653599999995 -12.929951999999986 241.19855199999998 -373.19363999999973 1940.6706399999996 CONFLICT 0.5 0.5 0.0 GO:0032270 7 positive regulation of cellular protein metabolic process 403 428 13 13 11 9 8 8 51 420 2068 0.31958 0.79965 0.59923 1.87 313506;78968;24494;24408;84488;25311;502902;24232 stil;srebf1;il1b;grin1;fgf13;dcc;clec7a;c3 STIL_33274;SREBF1_32750;IL1B_8892;GRIN1_32381;FGF13_32529;DCC_32537;CLEC7A_32927;C3_8175 246.1125 228.97899999999998 144.319 93.38088588295629 253.00488288180577 96.21817528269575 171.12695 153.65800000000002 57.6936 89.88084775216893 177.98010994954686 92.83399410625746 470.65362500000003 397.9955 153.26 349.5917204891352 472.05789808947657 337.43352446975996 311.636;177.986;153.991;310.025;209.76;248.198;412.985;144.319 177.242;117.256;109.464;254.954;130.074;183.659;338.673;57.6936 1285.89;348.781;258.668;447.21;483.266;299.409;488.745;153.26 4 4 4 24494;24408;502902;24232 IL1B_8892;GRIN1_32381;CLEC7A_32927;C3_8175 255.33 232.00799999999998 129.66582316606534 190.19615 182.209 129.5036163235993 336.97074999999995 352.93899999999996 158.1866782494132 153.991;310.025;412.985;144.319 109.464;254.954;338.673;57.6936 258.668;447.21;488.745;153.26 4 313506;78968;84488;25311 STIL_33274;SREBF1_32750;FGF13_32529;DCC_32537 236.89499999999998 228.97899999999998 57.505226997204616 152.05775 153.65800000000002 33.30331573457314 604.3365000000001 416.0235 460.9637126604074 311.636;177.986;209.76;248.198 177.242;117.256;130.074;183.659 1285.89;348.781;483.266;299.409 0 Exp 2,3(0.38);Exp 5,1(0.13);Linear,2(0.25);Poly 2,2(0.25) 1.8955537321808096 15.434987306594849 1.5889767408370972 2.8712503910064697 0.4193816177454833 1.8213455080986023 181.40284751177535 310.8221524882247 108.8427001945328 233.41119980546725 228.3989223195513 712.9083276804488 CONFLICT 0.5 0.5 0.0 GO:0120036 6 plasma membrane bounded cell projection organization 123 129 7 7 6 6 5 5 54 124 2364 0.92487 0.17615 0.22106 3.88 313506;338475;288280;25595;170924 stil;nrep;ncam2;map2;abcc4 STIL_33274;NREP_9364;NCAM2_32618;MAP2_32650;ABCC4_32768 247.6368 244.652 145.437 70.11998852467106 284.3043370689188 52.323621507155764 167.7836 152.355 104.718 58.68150469526152 200.85146153429702 59.99250664941133 611.0714 497.741 237.081 401.9978073339456 683.2851861837477 417.7519725285205 311.636;222.026;314.433;145.437;244.652 177.242;142.777;261.826;104.718;152.355 1285.89;497.741;415.493;237.081;619.152 3 2 3 288280;25595;170924 NCAM2_32618;MAP2_32650;ABCC4_32768 234.84066666666664 244.652 84.92413496959125 172.96633333333332 152.355 80.55650943488888 423.9086666666667 415.493 191.17447487657253 314.433;145.437;244.652 261.826;104.718;152.355 415.493;237.081;619.152 2 313506;338475 STIL_33274;NREP_9364 266.831 266.831 63.363838662126504 160.0095 160.0095 24.370435213594277 891.8155 891.8155 557.3055024853963 311.636;222.026 177.242;142.777 1285.89;497.741 0 Exp 2,1(0.2);Linear,4(0.8) 1.700467224082714 8.566151857376099 1.5347857475280762 2.1256394386291504 0.2438807357773204 1.6343638896942139 186.1739201183135 309.0996798816865 116.34699325993348 219.22020674006654 258.7047857902103 963.4380142097898 UP 0.6 0.4 0.0 GO:0046627 7 negative regulation of insulin receptor signaling pathway 17 17 4 4 3 3 2 2 57 15 2473 0.99363 0.05742 0.05742 11.76 365377;24494 trim72;il1b TRIM72_33144;IL1B_8892 118.0419 118.0419 82.0928 50.83970477510669 110.25435149643705 49.63248692368046 79.3848 79.3848 49.3056 42.538412585332814 72.86883078384798 41.52831366222713 226.0675 226.0675 193.467 46.1040692401443 219.00534893111643 45.00930176153064 0.0 82.0928 0.5 118.0419 82.0928;153.991 49.3056;109.464 193.467;258.668 2 0 2 365377;24494 TRIM72_33144;IL1B_8892 118.0419 118.0419 50.83970477510669 79.3848 79.3848 42.538412585332814 226.0675 226.0675 46.1040692401443 82.0928;153.991 49.3056;109.464 193.467;258.668 0 0 Linear,1(0.5);Poly 2,1(0.5) 2.187196770049066 4.53736412525177 1.6661137342453003 2.8712503910064697 0.8521603022523077 2.268682062625885 47.58166399999999 188.502136 20.429568000000003 138.340032 162.17052 289.96448 UP 1.0 0.0 0.0 GO:0010212 5 response to ionizing radiation 75 76 4 4 4 3 3 3 56 73 2415 0.90284 0.25696 0.25696 3.95 360243;24494;245920 top2a;il1b;cxcl10 TOP2A_10059;IL1B_8892;CXCL10_8408 233.84500000000003 203.468 153.991 98.61616704678802 251.32294890965738 107.18847973478022 135.21033333333332 109.464 108.442 45.48190609828633 145.32969574247144 48.00739441889504 961.1970000000001 572.253 258.668 958.1591049262119 1147.1114959501558 1034.3352101375249 203.468;153.991;344.076 108.442;109.464;187.725 572.253;258.668;2052.67 1 2 1 24494 IL1B_8892 153.991 153.991 109.464 109.464 258.668 258.668 153.991 109.464 258.668 2 360243;245920 TOP2A_10059;CXCL10_8408 273.772 273.772 99.42487028907804 148.0835 148.0835 56.06154693281306 1312.4615000000001 1312.4615000000001 1046.8128996838445 203.468;344.076 108.442;187.725 572.253;2052.67 0 Exp 2,1(0.34);Linear,2(0.67) 2.45291771716373 7.4223473072052 2.0807507038116455 2.8712503910064697 0.39526332492650895 2.470346212387085 122.25030164181214 345.43969835818785 83.74271150429166 186.67795516237499 -123.0620976250533 2045.4560976250532 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0048589 3 developmental growth 91 95 4 4 4 3 3 3 56 92 2396 0.82423 0.37897 0.48237 3.16 313506;24503;304729 stil;ina;gli2 STIL_33274;INA_32322;GLI2_8713 296.9983333333333 305.642 273.717 20.383752606754765 296.7657789682821 20.621535328578485 196.7206666666667 177.242 163.744 45.926250634395586 194.8789982260697 45.05703274602931 858.8436666666666 831.582 459.059 414.08909004263035 873.9868247356845 411.38206286402726 311.636;305.642;273.717 177.242;249.176;163.744 1285.89;459.059;831.582 1 2 1 24503 INA_32322 305.642 305.642 249.176 249.176 459.059 459.059 305.642 249.176 459.059 2 313506;304729 STIL_33274;GLI2_8713 292.67650000000003 292.67650000000003 26.812782035812145 170.493 170.493 9.544527332455957 1058.736 1058.736 321.2442675472976 311.636;273.717 177.242;163.744 1285.89;831.582 0 Exp 2,1(0.34);Linear,2(0.67) 1.8311698690151523 5.541668176651001 1.6343638896942139 2.1981756687164307 0.30622445590833186 1.7091286182403564 273.93194582630963 320.06472084035704 144.75022166005502 248.6911116732783 390.25774936165135 1327.429583971682 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0012501 4 programmed cell death 149 161 7 7 7 4 4 4 55 157 2331 0.68412 0.51861 0.78636 2.48 25247;24494;84488;25311 nsg1;il1b;fgf13;dcc NSG1_32675;IL1B_8892;FGF13_32529;DCC_32537 207.10524999999998 213.11599999999999 153.991 39.17703986924851 208.1454807612096 41.08766444326433 147.3585 148.15550000000002 109.464 33.70890650357364 145.6164901459854 34.90643009151502 345.97975 320.9925 258.668 97.72627827551459 351.87503201251315 106.84051961504355 216.472;153.991;209.76;248.198 166.237;109.464;130.074;183.659 342.576;258.668;483.266;299.409 2 2 2 25247;24494 NSG1_32675;IL1B_8892 185.2315 185.2315 44.180738795316586 137.8505 137.8505 40.144573288303725 300.622 300.622 59.33191579580086 216.472;153.991 166.237;109.464 342.576;258.668 2 84488;25311 FGF13_32529;DCC_32537 228.97899999999998 228.97899999999998 27.17977045524866 156.8665 156.8665 37.89031686988112 391.3375 391.3375 130.00653146861526 209.76;248.198 130.074;183.659 483.266;299.409 0 Exp 2,2(0.5);Linear,1(0.25);Poly 2,1(0.25) 2.373939364157392 9.90652060508728 1.6639630794525146 3.437419891357422 0.8233751052966236 2.402568817138672 168.71175092813672 245.4987490718633 114.3237716264979 180.39322837350215 250.20799728999557 441.7515027100044 CONFLICT 0.5 0.5 0.0 GO:0001101 4 response to acid chemical 195 202 10 10 10 7 7 7 52 195 2293 0.90914 0.18271 0.22742 3.47 78968;362282;58827;24494;24450;24408;25086 srebf1;pck1;mest;il1b;hmgcs2;grin1;cyp2e1 SREBF1_32750;PCK1_9439;MEST_9219;IL1B_8892;HMGCS2_8812;GRIN1_32381;CYP2E1_8421 252.7022857142857 269.456 153.991 71.70343910560665 246.39079611438555 81.57123765388911 168.99814285714288 162.134 109.464 50.799684757645764 167.53678873608382 58.2215413218927 787.1881428571429 506.507 258.668 821.6421723579813 780.3694844793713 892.24446941684 177.986;227.854;272.228;153.991;269.456;310.025;357.376 117.256;148.568;198.842;109.464;162.134;254.954;191.769 348.781;506.507;543.288;258.668;795.183;447.21;2610.68 6 1 6 362282;58827;24494;24450;24408;25086 PCK1_9439;MEST_9219;IL1B_8892;HMGCS2_8812;GRIN1_32381;CYP2E1_8421 265.15500000000003 270.842 69.76439660457184 177.62183333333334 176.9515 49.71959423976292 860.256 524.8975 874.796074864308 227.854;272.228;153.991;269.456;310.025;357.376 148.568;198.842;109.464;162.134;254.954;191.769 506.507;543.288;258.668;795.183;447.21;2610.68 1 78968 SREBF1_32750 177.986 177.986 117.256 117.256 348.781 348.781 177.986 117.256 348.781 0 Exp 2,4(0.58);Linear,3(0.43) 2.0305980014295164 14.437382340431213 1.5889767408370972 2.8712503910064697 0.41061328619630577 1.9169143438339233 199.58363466826614 305.8209367603053 131.36520974336426 206.63107597092144 178.50710352935835 1395.8691821849272 UP 0.8571428571428571 0.14285714285714285 0.0 GO:0034473 11 U1 snRNA 3'-end processing 2 2 1 1 1 1 1 1 58 1 2487 0.99947 0.045801 0.045801 50.0 316098 exosc7 EXOSC7_8580 111.985 111.985 111.985 111.985 54.886 54.886 54.886 54.886 373.527 373.527 373.527 373.527 0.0 111.985 0.0 111.985 111.985 54.886 373.527 1 0 1 316098 EXOSC7_8580 111.985 111.985 54.886 54.886 373.527 373.527 111.985 54.886 373.527 0 0 Poly 2,1(1) 1.9251312017440796 1.9251312017440796 1.9251312017440796 1.9251312017440796 0.0 1.9251312017440796 111.985 111.985 54.886 54.886 373.527 373.527 UP 1.0 0.0 0.0 GO:0034476 11 U5 snRNA 3'-end processing 2 2 1 1 1 1 1 1 58 1 2487 0.99947 0.045801 0.045801 50.0 316098 exosc7 EXOSC7_8580 111.985 111.985 111.985 111.985 54.886 54.886 54.886 54.886 373.527 373.527 373.527 373.527 0.0 111.985 0.0 111.985 111.985 54.886 373.527 1 0 1 316098 EXOSC7_8580 111.985 111.985 54.886 54.886 373.527 373.527 111.985 54.886 373.527 0 0 Poly 2,1(1) 1.9251312017440796 1.9251312017440796 1.9251312017440796 1.9251312017440796 0.0 1.9251312017440796 111.985 111.985 54.886 54.886 373.527 373.527 UP 1.0 0.0 0.0 GO:0048232 5 male gamete generation 67 75 4 4 3 2 2 2 57 73 2415 0.74935 0.52421 0.69215 2.67 311715;29650 tcfl5;adam10 TCFL5_9994;ADAM10_7983 293.846 293.846 270.921 32.420845917403454 282.9786310070031 28.546660616263285 203.81799999999998 203.81799999999998 178.963 35.15027809278333 215.60026636078243 30.94993455255021 856.4385 856.4385 338.867 731.9566347977865 611.088861144651 644.4902052410104 270.921;316.771 228.673;178.963 338.867;1374.01 1 1 1 311715 TCFL5_9994 270.921 270.921 228.673 228.673 338.867 338.867 270.921 228.673 338.867 1 29650 ADAM10_7983 316.771 316.771 178.963 178.963 1374.01 1374.01 316.771 178.963 1374.01 0 Exp 2,1(0.5);Linear,1(0.5) 1.7411691428886504 3.4881441593170166 1.6434866189956665 1.84465754032135 0.14224932264693632 1.7440720796585083 248.91299999999998 338.779 155.10219999999998 252.53379999999999 -158.00163999999995 1870.87864 CONFLICT 0.5 0.5 0.0 GO:0090304 5 nucleic acid metabolic process 251 278 10 10 7 8 6 6 53 272 2216 0.53142 0.63691 1.0 2.16 360243;78968;291773;316273;681410;316098 top2a;srebf1;taf4b;mcm3;loc681410;exosc7 TOP2A_10059;SREBF1_32750;RGD1562997_32695;MCM3_9207;LOC681410_33126;EXOSC7_8580 235.5041666666667 216.2805 111.985 102.23434831291611 229.13279100096446 82.95857318591655 151.1345 125.387 54.886 93.35527976874153 143.72853491005156 75.92382044568954 548.8760000000001 533.7985 348.781 196.9130811012816 545.5066487608505 163.56652935117566 203.468;177.986;279.902;229.093;410.591;111.985 108.442;117.256;166.045;133.518;326.66;54.886 572.253;348.781;888.462;614.889;495.344;373.527 2 4 2 681410;316098 LOC681410_33126;EXOSC7_8580 261.288 261.288 211.1463275029902 190.77300000000002 190.77300000000002 192.17323835019275 434.4355 434.4355 86.13762676380146 410.591;111.985 326.66;54.886 495.344;373.527 4 360243;78968;291773;316273 TOP2A_10059;SREBF1_32750;RGD1562997_32695;MCM3_9207 222.61224999999996 216.2805 43.520570127814366 131.31525 125.387 25.376207483585958 606.09625 593.571 221.48305629607395 203.468;177.986;279.902;229.093 108.442;117.256;166.045;133.518 572.253;348.781;888.462;614.889 0 Exp 2,3(0.5);Linear,1(0.17);Poly 2,2(0.34) 1.7950746253180452 10.817612409591675 1.5889767408370972 2.0807507038116455 0.18566305509964254 1.792263388633728 153.69965073281372 317.30868260051955 76.43471859212579 225.83428140787422 391.31271969004223 706.4392803099579 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0150062 8 complement-mediated synapse pruning 2 2 2 2 2 2 2 2 57 0 2488 1.0 5.2771E-4 5.2771E-4 100.0 24232;298566 c3;c1qa C3_8175;C1QA_8167 206.387 206.387 144.319 87.7774073893732 223.1492151552795 84.51585374458585 109.7233 109.7233 57.6936 73.5811073862034 123.7745506583851 70.84704703832374 470.0985 470.0985 153.26 448.07730378194793 555.6645744099379 431.42805192134387 0.0 144.319 0.0 144.319 144.319;268.455 57.6936;161.753 153.26;786.937 2 0 2 24232;298566 C3_8175;C1QA_8167 206.387 206.387 87.7774073893732 109.7233 109.7233 73.5811073862034 470.0985 470.0985 448.07730378194793 144.319;268.455 57.6936;161.753 153.26;786.937 0 0 Exp 5,1(0.5);Linear,1(0.5) 1.8659134291134991 3.743206262588501 1.7257766723632812 2.0174295902252197 0.20622975597301985 1.8716031312942505 84.73372 328.04028 7.745088000000024 211.70151199999998 -150.9049599999999 1091.10196 UP 1.0 0.0 0.0 GO:0010243 5 response to organonitrogen compound 400 420 15 15 14 10 9 9 50 411 2077 0.48286 0.65695 1.0 2.14 78968;79212;362282;24494;24450;24408;25311;25086;170924 srebf1;slc6a1;pck1;il1b;hmgcs2;grin1;dcc;cyp2e1;abcc4 SREBF1_32750;SLC6A1_32594;PCK1_9439;IL1B_8892;HMGCS2_8812;GRIN1_32381;DCC_32537;CYP2E1_8421;ABCC4_32768 237.22033333333334 244.652 145.445 70.6213927769057 222.28322696750618 75.11587661910127 158.32011111111112 152.355 104.722 47.6840726014579 152.50305297280607 51.61184561833687 680.299 447.21 237.101 746.4098052678569 584.3406196197483 722.6744495480865 177.986;145.445;227.854;153.991;269.456;310.025;248.198;357.376;244.652 117.256;104.722;148.568;109.464;162.134;254.954;183.659;191.769;152.355 348.781;237.101;506.507;258.668;795.183;447.21;299.409;2610.68;619.152 7 2 7 79212;362282;24494;24450;24408;25086;170924 SLC6A1_32594;PCK1_9439;IL1B_8892;HMGCS2_8812;GRIN1_32381;CYP2E1_8421;ABCC4_32768 244.1141428571429 244.652 77.39203368010715 160.56657142857145 152.355 51.35906223136976 782.0715714285715 506.507 829.6119382689027 145.445;227.854;153.991;269.456;310.025;357.376;244.652 104.722;148.568;109.464;162.134;254.954;191.769;152.355 237.101;506.507;258.668;795.183;447.21;2610.68;619.152 2 78968;25311 SREBF1_32750;DCC_32537 213.09199999999998 213.09199999999998 49.64738132066996 150.45749999999998 150.45749999999998 46.95401159113043 324.095 324.095 34.91127600074178 177.986;248.198 117.256;183.659 348.781;299.409 0 Exp 2,3(0.34);Linear,5(0.56);Poly 2,1(0.12) 1.9401967970577185 17.734097957611084 1.5415009260177612 2.8712503910064697 0.3894115029723981 1.9169143438339233 191.08102338575486 283.35964328091177 127.16651701149193 189.47370521073032 192.64459389166683 1167.9534061083332 UP 0.7777777777777778 0.2222222222222222 0.0 GO:0051088 8 PMA-inducible membrane protein ectodomain proteolysis 1 1 1 1 1 1 1 1 58 0 2488 1.0 0.023165 0.023165 100.0 29650 adam10 ADAM10_7983 316.771 316.771 316.771 316.771 178.963 178.963 178.963 178.963 1374.01 1374.01 1374.01 1374.01 0.0 316.771 0.0 316.771 316.771 178.963 1374.01 0 1 0 1 29650 ADAM10_7983 316.771 316.771 178.963 178.963 1374.01 1374.01 316.771 178.963 1374.01 0 Linear,1(1) 1.6434866189956665 1.6434866189956665 1.6434866189956665 1.6434866189956665 0.0 1.6434866189956665 316.771 316.771 178.963 178.963 1374.01 1374.01 DOWN 0.0 1.0 0.0 GO:0051089 8 constitutive protein ectodomain proteolysis 1 1 1 1 1 1 1 1 58 0 2488 1.0 0.023165 0.023165 100.0 29650 adam10 ADAM10_7983 316.771 316.771 316.771 316.771 178.963 178.963 178.963 178.963 1374.01 1374.01 1374.01 1374.01 0.0 316.771 0.0 316.771 316.771 178.963 1374.01 0 1 0 1 29650 ADAM10_7983 316.771 316.771 178.963 178.963 1374.01 1374.01 316.771 178.963 1374.01 0 Linear,1(1) 1.6434866189956665 1.6434866189956665 1.6434866189956665 1.6434866189956665 0.0 1.6434866189956665 316.771 316.771 178.963 178.963 1374.01 1374.01 DOWN 0.0 1.0 0.0 GO:0044248 4 cellular catabolic process 306 344 12 12 12 9 9 9 50 335 2153 0.73211 0.40219 0.69894 2.62 365377;362282;24451;316098;25315;171142;29740;25086;25279 trim72;pck1;hmox1;exosc7;ephx1;ehhadh;eci1;cyp2e1;cyp24a1 TRIM72_33144;PCK1_9439;HMOX1_8815;EXOSC7_8580;EPHX1_8567;EHHADH_8534;ECI1_8520;CYP2E1_8421;CYP24A1_32574 165.4060888888889 189.111 12.5094 108.1225706497543 171.80712916892995 98.6108280735809 100.38866666666667 127.579 3.282 64.60076831540007 106.05136770906081 58.07168733763289 586.1729555555555 373.527 61.3966 780.1662090390532 569.3121667675437 735.6603469290562 82.0928;227.854;61.2776;111.985;12.5094;250.691;195.758;357.376;189.111 49.3056;148.568;39.7754;54.886;3.282;157.555;130.778;191.769;127.579 193.467;506.507;140.784;373.527;61.3966;636.947;388.001;2610.68;364.247 9 0 9 365377;362282;24451;316098;25315;171142;29740;25086;25279 TRIM72_33144;PCK1_9439;HMOX1_8815;EXOSC7_8580;EPHX1_8567;EHHADH_8534;ECI1_8520;CYP2E1_8421;CYP24A1_32574 165.4060888888889 189.111 108.1225706497543 100.38866666666667 127.579 64.60076831540007 586.1729555555555 373.527 780.1662090390532 82.0928;227.854;61.2776;111.985;12.5094;250.691;195.758;357.376;189.111 49.3056;148.568;39.7754;54.886;3.282;157.555;130.778;191.769;127.579 193.467;506.507;140.784;373.527;61.3966;636.947;388.001;2610.68;364.247 0 0 Exp 2,2(0.23);Hill,1(0.12);Linear,3(0.34);Poly 2,3(0.34) 1.8226308624846403 16.5451797246933 1.5261523723602295 2.162810802459717 0.25598675077283 1.8089147806167603 94.7660093977161 236.04616838006172 58.18283136727193 142.5945019660614 76.46436565004075 1095.8815454610703 UP 1.0 0.0 0.0 GO:0006805 4 xenobiotic metabolic process 43 62 3 3 3 2 2 2 57 60 2428 0.82814 0.4241 0.6538 3.23 24408;25086 grin1;cyp2e1 GRIN1_32381;CYP2E1_8421 333.7005 333.7005 310.025 33.48221319596455 332.1004109117719 33.40565865717129 223.3615 223.3615 191.769 44.67854196927189 225.49665298599163 44.57638787466781 1528.945 1528.945 447.21 1529.80430789366 1455.8368346030963 1526.3065264731713 310.025;357.376 254.954;191.769 447.21;2610.68 2 0 2 24408;25086 GRIN1_32381;CYP2E1_8421 333.7005 333.7005 33.48221319596455 223.3615 223.3615 44.67854196927189 1528.945 1528.945 1529.80430789366 310.025;357.376 254.954;191.769 447.21;2610.68 0 0 Exp 2,1(0.5);Linear,1(0.5) 1.8621317594997038 3.7258291244506836 1.8089147806167603 1.9169143438339233 0.07636722351604125 1.8629145622253418 287.29652 380.10447999999997 161.4402 285.2828 -591.2555999999997 3649.1456 UP 1.0 0.0 0.0 GO:0046890 6 regulation of lipid biosynthetic process 73 78 4 4 4 3 3 3 56 75 2413 0.89553 0.26964 0.42584 3.85 78968;24494;24232 srebf1;il1b;c3 SREBF1_32750;IL1B_8892;C3_8175 158.76533333333333 153.991 144.319 17.333851745452545 158.74853446661385 17.097787289659127 94.80453333333332 109.464 57.6936 32.374292975342875 95.57203250018007 31.881285794895703 253.56966666666668 258.668 153.26 97.86015589775717 254.60466505798456 96.12159166155966 177.986;153.991;144.319 117.256;109.464;57.6936 348.781;258.668;153.26 2 1 2 24494;24232 IL1B_8892;C3_8175 149.155 149.155 6.839136787636285 83.5788 83.5788 36.607200904740054 205.964 205.964 74.5347115913116 153.991;144.319 109.464;57.6936 258.668;153.26 1 78968 SREBF1_32750 177.986 177.986 117.256 117.256 348.781 348.781 177.986 117.256 348.781 0 Exp 2,1(0.34);Exp 5,1(0.34);Linear,1(0.34) 1.9894104760961626 6.186003804206848 1.5889767408370972 2.8712503910064697 0.7041602534563788 1.7257766723632812 139.1502335495262 178.38043311714046 58.16957207562285 131.43949459104383 142.83047545966934 364.308857873664 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0042908 5 xenobiotic transport 11 11 2 2 2 2 2 2 57 9 2479 0.99829 0.025371 0.025371 18.18 79212;170924 slc6a1;abcc4 SLC6A1_32594;ABCC4_32768 195.0485 195.0485 145.445 70.1499424411738 175.48891092922486 64.46595516444957 128.5385 128.5385 104.722 33.68161730825878 119.14720799229657 30.95252192232635 428.1265 428.1265 237.101 270.1508528591017 352.80156764564276 248.26154038054912 0.0 145.445 0.5 195.0485 145.445;244.652 104.722;152.355 237.101;619.152 2 0 2 79212;170924 SLC6A1_32594;ABCC4_32768 195.0485 195.0485 70.1499424411738 128.5385 128.5385 33.68161730825878 428.1265 428.1265 270.1508528591017 145.445;244.652 104.722;152.355 237.101;619.152 0 0 Linear,2(1) 1.756622294565745 3.543265461921692 1.5415009260177612 2.0017645359039307 0.32545551968391007 1.771632730960846 97.82563999999999 292.27135999999996 81.85816000000001 175.21884 53.71652 802.53648 UP 1.0 0.0 0.0 GO:0071639 8 positive regulation of monocyte chemotactic protein-1 production 5 5 2 2 2 2 2 2 57 3 2485 0.99989 0.0050446 0.0050446 40.0 24494;502902 il1b;clec7a IL1B_8892;CLEC7A_32927 283.488 283.488 153.991 183.13641368662874 302.5520299948285 181.14102665799535 224.0685 224.0685 109.464 162.07523820898734 240.94011575590415 160.30932600466596 373.7065 373.7065 258.668 162.68900689505733 390.64200749870713 160.9164072928005 0.0 153.991 0.0 153.991 153.991;412.985 109.464;338.673 258.668;488.745 2 0 2 24494;502902 IL1B_8892;CLEC7A_32927 283.488 283.488 183.13641368662874 224.0685 224.0685 162.07523820898734 373.7065 373.7065 162.68900689505733 153.991;412.985 109.464;338.673 258.668;488.745 0 0 Linear,1(0.5);Poly 2,1(0.5) 2.455444834475257 4.971105337142944 2.0998549461364746 2.8712503910064697 0.5454589500439871 2.485552668571472 29.673880000000025 537.3021200000001 -0.5563199999999711 448.69331999999997 148.23104 599.18196 UP 1.0 0.0 0.0 GO:0051252 6 regulation of RNA metabolic process 500 535 16 16 14 12 11 11 48 524 1964 0.39725 0.72323 0.74788 2.06 360243;311715;78968;291773;362282;681410;24494;24451;24408;304729;25311 top2a;tcfl5;srebf1;taf4b;pck1;loc681410;il1b;hmox1;grin1;gli2;dcc TOP2A_10059;TCFL5_9994;SREBF1_32750;RGD1562997_32695;PCK1_9439;LOC681410_33126;IL1B_8892;HMOX1_8815;GRIN1_32381;GLI2_8713;DCC_32537 237.99369090909093 248.198 61.2776 90.7633879297754 227.14286895883308 91.00383343189601 167.93094545454545 163.744 39.7754 79.40404076514452 161.4287674444525 77.65265512796911 466.1697272727273 447.21 140.784 230.79781944207838 429.4417105231276 229.1982485864185 203.468;270.921;177.986;279.902;227.854;410.591;153.991;61.2776;310.025;273.717;248.198 108.442;228.673;117.256;166.045;148.568;326.66;109.464;39.7754;254.954;163.744;183.659 572.253;338.867;348.781;888.462;506.507;495.344;258.668;140.784;447.21;831.582;299.409 6 5 6 311715;362282;681410;24494;24451;24408 TCFL5_9994;PCK1_9439;LOC681410_33126;IL1B_8892;HMOX1_8815;GRIN1_32381 239.10993333333332 249.3875 122.01878092632565 184.68240000000003 188.6205 104.87230882516123 364.56333333333333 393.0385 145.6251159569209 270.921;227.854;410.591;153.991;61.2776;310.025 228.673;148.568;326.66;109.464;39.7754;254.954 338.867;506.507;495.344;258.668;140.784;447.21 5 360243;78968;291773;304729;25311 TOP2A_10059;SREBF1_32750;RGD1562997_32695;GLI2_8713;DCC_32537 236.6542 248.198 44.498775906759526 147.8292 163.744 32.9959955100615 588.0974 572.253 269.4290351767976 203.468;177.986;279.902;273.717;248.198 108.442;117.256;166.045;163.744;183.659 572.253;348.781;888.462;831.582;299.409 0 Exp 2,5(0.46);Linear,3(0.28);Poly 2,3(0.28) 1.9313911084645132 21.5606871843338 1.5889767408370972 2.8712503910064697 0.37238228992364225 1.9169143438339233 184.35595628813698 291.6314255300448 121.00615602637316 214.85573488271774 329.77693197615724 602.5625225692972 CONFLICT 0.5454545454545454 0.45454545454545453 0.0 GO:0071456 5 cellular response to hypoxia 57 60 2 2 2 2 2 2 57 58 2430 0.83953 0.40777 0.64877 3.33 362282;24451 pck1;hmox1 PCK1_9439;HMOX1_8815 144.5658 144.5658 61.2776 117.78730202564284 100.1698872246696 99.6586894162798 94.1717 94.1717 39.7754 76.92798520291561 65.1763154185022 65.08801927637745 323.64549999999997 323.64549999999997 140.784 258.60521333588775 226.1730704845815 218.80335311238616 227.854;61.2776 148.568;39.7754 506.507;140.784 2 0 2 362282;24451 PCK1_9439;HMOX1_8815 144.5658 144.5658 117.78730202564284 94.1717 94.1717 76.92798520291561 323.64549999999997 323.64549999999997 258.60521333588775 227.854;61.2776 148.568;39.7754 506.507;140.784 0 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.8558058141879288 3.755190134048462 1.5923793315887451 2.162810802459717 0.4033559612550806 1.877595067024231 -18.679071999999962 307.810672 -12.445048000000014 200.78844800000002 -34.76303999999999 682.05404 UP 1.0 0.0 0.0 GO:0048143 5 astrocyte activation 10 11 2 2 2 2 2 2 57 9 2479 0.99829 0.025371 0.025371 18.18 24494;298566 il1b;c1qa IL1B_8892;C1QA_8167 211.223 211.223 153.991 80.93827060173687 223.5676906064209 79.03303660915164 135.6085 135.6085 109.464 36.973906481463416 141.24775362663496 36.10356488726515 522.8025 522.8025 258.668 373.54259219063636 579.7751495838288 364.74964370002687 0.0 153.991 0.5 211.223 153.991;268.455 109.464;161.753 258.668;786.937 2 0 2 24494;298566 IL1B_8892;C1QA_8167 211.223 211.223 80.93827060173687 135.6085 135.6085 36.973906481463416 522.8025 522.8025 373.54259219063636 153.991;268.455 109.464;161.753 258.668;786.937 0 0 Linear,2(1) 2.4067707617806446 4.8886799812316895 2.0174295902252197 2.8712503910064697 0.6037424781505502 2.4443399906158447 99.04828000000008 323.39771999999994 84.36528000000001 186.85171999999997 5.098880000000008 1040.50612 UP 1.0 0.0 0.0 GO:0006954 5 inflammatory response 129 140 9 9 8 5 5 5 54 135 2353 0.89794 0.22137 0.25558 3.57 29142;681410;24494;245920;24232 vnn1;loc681410;il1b;cxcl10;c3 VNN1_10157;LOC681410_33126;IL1B_8892;CXCL10_8408;C3_8175 257.34360000000004 233.741 144.319 117.28243440004132 253.11128712871292 114.57978520023538 165.87232 147.819 57.6936 101.90764698005744 154.77978247193138 89.86840462769928 703.3586 495.344 153.26 772.2910727651847 866.809070917618 911.6301050124977 233.741;410.591;153.991;344.076;144.319 147.819;326.66;109.464;187.725;57.6936 556.851;495.344;258.668;2052.67;153.26 4 1 4 29142;681410;24494;24232 VNN1_10157;LOC681410_33126;IL1B_8892;C3_8175 235.6605 193.866 123.31199071596127 160.40915 128.6415 116.82429759125453 366.03075 377.006 191.4266061085814 233.741;410.591;153.991;144.319 147.819;326.66;109.464;57.6936 556.851;495.344;258.668;153.26 1 245920 CXCL10_8408 344.076 344.076 187.725 187.725 2052.67 2052.67 344.076 187.725 2052.67 0 Exp 5,1(0.2);Linear,3(0.6);Poly 2,1(0.2) 2.1008875194869807 10.729721903800964 1.7257766723632812 2.8712503910064697 0.5063145765573899 1.929691195487976 154.5410136130203 360.14618638697965 76.54632897881187 255.19831102118815 26.415627849277712 1380.3015721507222 UP 0.8 0.2 0.0 GO:0008203 6 cholesterol metabolic process 48 49 4 4 3 2 2 2 57 47 2441 0.89717 0.31475 0.31475 4.08 78968;24450 srebf1;hmgcs2 SREBF1_32750;HMGCS2_8812 223.721 223.721 177.986 64.67905727513359 199.2530462633452 54.64447757900011 139.695 139.695 117.256 31.733538126089943 127.69026809015419 26.81026418268697 571.982 571.982 348.781 315.65388133523743 452.57078884934754 266.6820168385348 177.986;269.456 117.256;162.134 348.781;795.183 1 1 1 24450 HMGCS2_8812 269.456 269.456 162.134 162.134 795.183 795.183 269.456 162.134 795.183 1 78968 SREBF1_32750 177.986 177.986 117.256 117.256 348.781 348.781 177.986 117.256 348.781 0 Exp 2,1(0.5);Linear,1(0.5) 1.7412328590488502 3.497054934501648 1.5889767408370972 1.9080781936645508 0.22563880118077165 1.748527467250824 134.0804 313.3616 95.71456 183.67543999999998 134.50804 1009.45596 CONFLICT 0.5 0.5 0.0 GO:0030030 5 cell projection organization 158 167 10 10 9 8 7 7 52 160 2328 0.96376 0.087904 0.10534 4.19 313506;338475;288280;25595;304729;25311;170924 stil;nrep;ncam2;map2;gli2;dcc;abcc4 STIL_33274;NREP_9364;NCAM2_32618;MAP2_32650;GLI2_8713;DCC_32537;ABCC4_32768 251.4427142857143 248.198 145.437 58.08951146783249 275.174433715612 42.96814332250457 169.47442857142855 163.744 104.718 48.343235234646734 191.21013325141647 48.42590466408754 598.0497142857142 497.741 237.081 363.0840982929963 629.2846855758072 372.3879893961725 311.636;222.026;314.433;145.437;273.717;248.198;244.652 177.242;142.777;261.826;104.718;163.744;183.659;152.355 1285.89;497.741;415.493;237.081;831.582;299.409;619.152 3 4 3 288280;25595;170924 NCAM2_32618;MAP2_32650;ABCC4_32768 234.84066666666664 244.652 84.92413496959125 172.96633333333332 152.355 80.55650943488888 423.9086666666667 415.493 191.17447487657253 314.433;145.437;244.652 261.826;104.718;152.355 415.493;237.081;619.152 4 313506;338475;304729;25311 STIL_33274;NREP_9364;GLI2_8713;DCC_32537 263.89425 260.9575 38.188496229231276 166.85549999999998 170.493 18.071087303572593 728.6555000000001 664.6614999999999 431.53918959348294 311.636;222.026;273.717;248.198 177.242;142.777;163.744;183.659 1285.89;497.741;831.582;299.409 0 Exp 2,1(0.15);Linear,5(0.72);Poly 2,1(0.15) 1.7967034856373982 12.698214769363403 1.5347857475280762 2.1981756687164307 0.27405830652182234 1.729861855506897 208.40940197068096 294.4760266007476 133.6612587305409 205.28759841231624 329.07325014180253 867.0261784296262 CONFLICT 0.42857142857142855 0.5714285714285714 0.0 GO:0042391 4 regulation of membrane potential 94 95 5 5 3 4 2 2 57 93 2395 0.62103 0.65452 1.0 2.11 24408;84488 grin1;fgf13 GRIN1_32381;FGF13_32529 259.8925 259.8925 209.76 70.8980614156693 251.6399192307692 69.93085823722335 192.514 192.514 130.074 88.3034948345761 182.23541538461538 87.09884383049388 465.238 465.238 447.21 25.49544210246236 468.2056861538461 25.14762902908843 310.025;209.76 254.954;130.074 447.21;483.266 1 1 1 24408 GRIN1_32381 310.025 310.025 254.954 254.954 447.21 447.21 310.025 254.954 447.21 1 84488 FGF13_32529 209.76 209.76 130.074 130.074 483.266 483.266 209.76 130.074 483.266 0 Exp 2,2(1) 1.785966039602263 3.580877423286438 1.6639630794525146 1.9169143438339233 0.1788635543538053 1.790438711643219 161.63280000000003 358.15219999999994 70.1316 314.8964 429.90311999999994 500.57288000000005 CONFLICT 0.5 0.5 0.0 GO:0043170 4 macromolecule metabolic process 853 925 25 24 19 18 15 15 44 910 1578 0.049627 0.97373 0.099391 1.62 365377;360243;78968;291773;303872;362282;25247;316273;681410;24494;84488;316098;171142;297594;29650 trim72;top2a;srebf1;taf4b;pigz;pck1;nsg1;mcm3;loc681410;il1b;fgf13;exosc7;ehhadh;cdca3;adam10 TRIM72_33144;TOP2A_10059;SREBF1_32750;RGD1562997_32695;PIGZ_32744;PCK1_9439;NSG1_32675;MCM3_9207;LOC681410_33126;IL1B_8892;FGF13_32529;EXOSC7_8580;EHHADH_8534;CDCA3_8260;ADAM10_7983 227.26585333333335 216.472 82.0928 87.16723306746027 215.33742400360765 85.11170949720207 144.7323066666667 133.518 49.3056 66.48971373751266 135.34674989969983 60.75514598628496 530.3806000000001 483.266 193.467 288.4097021279673 473.5519401775855 208.4279136611342 82.0928;203.468;177.986;279.902;355.097;227.854;216.472;229.093;410.591;153.991;209.76;111.985;250.691;183.234;316.771 49.3056;108.442;117.256;166.045;212.48;148.568;166.237;133.518;326.66;109.464;130.074;54.886;157.555;111.531;178.963 193.467;572.253;348.781;888.462;459.59;506.507;342.576;614.889;495.344;258.668;483.266;373.527;636.947;407.422;1374.01 8 7 8 365377;303872;362282;25247;681410;24494;316098;171142 TRIM72_33144;PIGZ_32744;PCK1_9439;NSG1_32675;LOC681410_33126;IL1B_8892;EXOSC7_8580;EHHADH_8534 226.096725 222.163 113.60184979821598 153.14445 153.06150000000002 89.59063788376554 408.32825 416.5585 144.52045832807588 82.0928;355.097;227.854;216.472;410.591;153.991;111.985;250.691 49.3056;212.48;148.568;166.237;326.66;109.464;54.886;157.555 193.467;459.59;506.507;342.576;495.344;258.668;373.527;636.947 7 360243;78968;291773;316273;84488;297594;29650 TOP2A_10059;SREBF1_32750;RGD1562997_32695;MCM3_9207;FGF13_32529;CDCA3_8260;ADAM10_7983 228.602 209.76 51.6602320326446 135.11842857142855 130.074 27.36747424015807 669.869 572.253 356.5916765125062 203.468;177.986;279.902;229.093;209.76;183.234;316.771 108.442;117.256;166.045;133.518;130.074;111.531;178.963 572.253;348.781;888.462;614.889;483.266;407.422;1374.01 0 Exp 2,8(0.54);Linear,3(0.2);Poly 2,4(0.27) 1.9235877392360223 29.60798406600952 1.5889767408370972 3.437419891357422 0.5201705073643007 1.8452895879745483 183.15314704464674 271.3785596220199 111.08386894406728 178.38074438926606 384.42515283176874 676.3360471682312 CONFLICT 0.5333333333333333 0.4666666666666667 0.0 GO:0035249 8 synaptic transmission, glutamatergic 10 10 3 3 2 3 2 2 57 8 2480 0.99874 0.021069 0.021069 20.0 84487;24408 slc17a6;grin1 SLC17A6_32912;GRIN1_32381 339.828 339.828 310.025 42.14780679940531 350.2704149842978 39.47593642450409 209.202 209.202 163.45 64.70309890569382 193.17135307312694 60.60138386383503 449.6575 449.6575 447.21 3.461287693897414 450.51505832211757 3.2418667382105664 0.0 310.025 0.0 310.025 369.631;310.025 163.45;254.954 452.105;447.21 2 0 2 84487;24408 SLC17A6_32912;GRIN1_32381 339.828 339.828 42.14780679940531 209.202 209.202 64.70309890569382 449.6575 449.6575 3.461287693897414 369.631;310.025 163.45;254.954 452.105;447.21 0 0 Exp 2,1(0.5);Hill,1(0.5) 1.8924486999525418 3.7852096557617188 1.8682953119277954 1.9169143438339233 0.034378847155548176 1.8926048278808594 281.41412 398.2418799999999 119.52807999999999 298.87592 444.86039999999997 454.4546000000001 UP 1.0 0.0 0.0 GO:0043200 5 response to amino acid 78 82 4 4 4 3 3 3 56 79 2409 0.88018 0.29523 0.43701 3.66 362282;24450;24408 pck1;hmgcs2;grin1 PCK1_9439;HMGCS2_8812;GRIN1_32381 269.1116666666667 269.456 227.854 41.08658216904056 285.7844278718343 40.25427897418894 188.552 162.134 148.568 57.90447557831788 215.83445249755144 59.871199181152555 582.9666666666667 506.507 447.21 186.16085155674725 525.8825847208619 163.213985878618 227.854;269.456;310.025 148.568;162.134;254.954 506.507;795.183;447.21 3 0 3 362282;24450;24408 PCK1_9439;HMGCS2_8812;GRIN1_32381 269.1116666666667 269.456 41.08658216904056 188.552 162.134 57.90447557831788 582.9666666666667 506.507 186.16085155674725 227.854;269.456;310.025 148.568;162.134;254.954 506.507;795.183;447.21 0 0 Exp 2,2(0.67);Linear,1(0.34) 1.9925342799184453 5.987803339958191 1.9080781936645508 2.162810802459717 0.14458667982569795 1.9169143438339233 222.61782208692716 315.6055112464062 123.02691745764527 254.07708254235473 372.30583185930493 793.6275014740285 UP 1.0 0.0 0.0 GO:0043207 4 response to external biotic stimulus 357 390 19 19 17 14 13 13 46 377 2111 0.94311 0.10573 0.1452 3.33 29142;294228;362282;25211;681410;24494;24450;304729;25086;245920;502902;24232;298566 vnn1;rt1-s3;pck1;lyz2;loc681410;il1b;hmgcs2;gli2;cyp2e1;cxcl10;clec7a;c3;c1qa VNN1_10157;RT1-S3_9763;PCK1_9439;LYZ2_32611;LOC681410_33126;IL1B_8892;HMGCS2_8812;GLI2_8713;CYP2E1_8421;CXCL10_8408;CLEC7A_32927;C3_8175;C1QA_8167 271.5756153846154 268.455 144.319 87.22468433642928 272.2532984049805 87.84490233973297 175.1595846153846 161.753 57.6936 77.76613749769076 175.58345702317789 78.2315868811439 806.5633846153846 506.507 153.26 713.3731622606475 821.5567348423871 715.5784496633288 233.741;219.207;227.854;214.715;410.591;153.991;269.456;273.717;357.376;344.076;412.985;144.319;268.455 147.819;141.536;148.568;139.536;326.66;109.464;162.134;163.744;191.769;187.725;338.673;57.6936;161.753 556.851;484.566;506.507;464.331;495.344;258.668;795.183;831.582;2610.68;2052.67;488.745;153.26;786.937 10 3 10 29142;362282;25211;681410;24494;24450;25086;502902;24232;298566 VNN1_10157;PCK1_9439;LYZ2_32611;LOC681410_33126;IL1B_8892;HMGCS2_8812;CYP2E1_8421;CLEC7A_32927;C3_8175;C1QA_8167 269.3483 251.098 96.17390162160531 178.40696 155.1605 88.84859815597916 711.6505999999999 500.9255 695.9917714272842 233.741;227.854;214.715;410.591;153.991;269.456;357.376;412.985;144.319;268.455 147.819;148.568;139.536;326.66;109.464;162.134;191.769;338.673;57.6936;161.753 556.851;506.507;464.331;495.344;258.668;795.183;2610.68;488.745;153.26;786.937 3 294228;304729;245920 RT1-S3_9763;GLI2_8713;CXCL10_8408 279.0 273.717 62.6019117679324 164.335 163.744 23.100170800234235 1122.9393333333335 831.582 823.6530583135917 219.207;273.717;344.076 141.536;163.744;187.725 484.566;831.582;2052.67 0 Exp 2,1(0.08);Exp 5,1(0.08);Linear,9(0.7);Poly 2,2(0.16) 1.9950899825257853 26.27234637737274 1.5622447729110718 2.8712503910064697 0.35178531083530457 1.929691195487976 224.1597368578564 318.9914939113744 132.88543072033033 217.43373851043887 418.76931618934685 1194.357453041422 UP 0.7692307692307693 0.23076923076923078 0.0 GO:0050877 4 nervous system process 155 163 10 10 9 9 8 8 51 155 2333 0.98868 0.031958 0.051237 4.91 79212;29483;288280;24494;24416;24408;84488;80841 slc6a1;slc1a3;ncam2;il1b;grm3;grin1;fgf13;fabp7 SLC6A1_32594;SLC1A3_32817;NCAM2_32618;IL1B_8892;GRM3_33234;GRIN1_32381;FGF13_32529;FABP7_8592 244.00912499999998 257.49199999999996 145.445 69.63534876039725 240.82752742758356 72.4390653913869 185.86974999999998 192.0495 104.722 64.69833728212369 185.40367637137916 68.81807258585845 434.094125 389.67650000000003 237.101 243.49385550442685 404.48836494919254 207.02167902771785 145.445;303.435;314.433;153.991;286.986;310.025;209.76;227.998 104.722;189.179;261.826;109.464;241.819;254.954;130.074;194.92 237.101;992.735;415.493;258.668;363.86;447.21;483.266;274.42 7 1 7 79212;29483;288280;24494;24416;24408;80841 SLC6A1_32594;SLC1A3_32817;NCAM2_32618;IL1B_8892;GRM3_33234;GRIN1_32381;FABP7_8592 248.90185714285715 286.986 73.71453748623483 193.84057142857142 194.92 65.50218857884863 427.06957142857146 363.86 262.1264071390349 145.445;303.435;314.433;153.991;286.986;310.025;227.998 104.722;189.179;261.826;109.464;241.819;254.954;194.92 237.101;992.735;415.493;258.668;363.86;447.21;274.42 1 84488 FGF13_32529 209.76 209.76 130.074 130.074 483.266 483.266 209.76 130.074 483.266 0 Exp 2,6(0.75);Linear,2(0.25) 2.380220881571922 20.811628699302673 1.6639630794525146 5.283818244934082 1.294365372178212 1.959339439868927 195.7542902276083 292.2639597723917 141.03608963678965 230.70341036321037 265.36149172365117 602.8267582763489 UP 0.875 0.125 0.0 GO:0060271 7 cilium assembly 15 16 2 2 2 2 2 2 57 14 2474 0.99466 0.051414 0.051414 12.5 313506;170924 stil;abcc4 STIL_33274;ABCC4_32768 278.144 278.144 244.652 47.364840630999694 282.46816614745586 46.96840749118925 164.7985 164.7985 152.355 17.5977664633896 166.40508549671165 17.450477087562028 952.5210000000001 952.5210000000001 619.152 471.4549610747565 995.5624112149534 467.50898832348696 0.0 244.652 0.5 278.144 311.636;244.652 177.242;152.355 1285.89;619.152 1 1 1 170924 ABCC4_32768 244.652 244.652 152.355 152.355 619.152 619.152 244.652 152.355 619.152 1 313506 STIL_33274 311.636 311.636 177.242 177.242 1285.89 1285.89 311.636 177.242 1285.89 0 Linear,2(1) 1.587253429485544 3.175864815711975 1.5415009260177612 1.6343638896942139 0.06566403133669971 1.5879324078559875 212.49967999999998 343.78832 140.40923999999998 189.18776 299.1177600000001 1605.92424 CONFLICT 0.5 0.5 0.0 GO:0031330 7 negative regulation of cellular catabolic process 57 58 2 2 2 2 2 2 57 56 2432 0.85068 0.39124 0.39124 3.45 681410;24451 loc681410;hmox1 LOC681410_33126;HMOX1_8815 235.9343 235.9343 61.2776 247.00187389932896 186.27793914707487 236.80882028224408 183.2177 183.2177 39.7754 202.85804607799028 142.43585418261344 194.48668068028164 318.06399999999996 318.06399999999996 140.784 250.71178033750232 267.6618130125752 240.36562960159102 410.591;61.2776 326.66;39.7754 495.344;140.784 2 0 2 681410;24451 LOC681410_33126;HMOX1_8815 235.9343 235.9343 247.00187389932896 183.2177 183.2177 202.85804607799028 318.06399999999996 318.06399999999996 250.71178033750232 410.591;61.2776 326.66;39.7754 495.344;140.784 0 0 Poly 2,2(1) 1.6610381947222155 3.3250367641448975 1.5923793315887451 1.7326574325561523 0.09919159644602485 1.6625183820724487 -106.392832 578.261432 -97.92920799999999 464.364608 -29.404800000000023 665.5328 UP 1.0 0.0 0.0 GO:0051239 4 regulation of multicellular organismal process 724 769 23 23 21 16 15 15 44 754 1734 0.25688 0.82871 0.47518 1.95 29142;78968;294228;338475;25595;24494;24451;24408;304729;84488;25311;245920;502902;24232;29650 vnn1;srebf1;rt1-s3;nrep;map2;il1b;hmox1;grin1;gli2;fgf13;dcc;cxcl10;clec7a;c3;adam10 VNN1_10157;SREBF1_32750;RT1-S3_9763;NREP_9364;MAP2_32650;IL1B_8892;HMOX1_8815;GRIN1_32381;GLI2_8713;FGF13_32529;DCC_32537;CXCL10_8408;CLEC7A_32927;C3_8175;ADAM10_7983 231.56777333333335 222.026 61.2776 90.50708699022614 239.64209585938426 94.74163818690809 153.25539999999998 142.777 39.7754 73.67839330627596 160.81075541760057 80.25766985041273 576.9749333333333 483.266 140.784 510.0526717969523 587.3977702754512 544.3762386097209 233.741;177.986;219.207;222.026;145.437;153.991;61.2776;310.025;273.717;209.76;248.198;344.076;412.985;144.319;316.771 147.819;117.256;141.536;142.777;104.718;109.464;39.7754;254.954;163.744;130.074;183.659;187.725;338.673;57.6936;178.963 556.851;348.781;484.566;497.741;237.081;258.668;140.784;447.21;831.582;483.266;299.409;2052.67;488.745;153.26;1374.01 7 8 7 29142;25595;24494;24451;24408;502902;24232 VNN1_10157;MAP2_32650;IL1B_8892;HMOX1_8815;GRIN1_32381;CLEC7A_32927;C3_8175 208.8250857142857 153.991 119.37309721953591 150.44242857142856 109.464 108.76564282195172 326.0855714285714 258.668 168.84617906530295 233.741;145.437;153.991;61.2776;310.025;412.985;144.319 147.819;104.718;109.464;39.7754;254.954;338.673;57.6936 556.851;237.081;258.668;140.784;447.21;488.745;153.26 8 78968;294228;338475;304729;84488;25311;245920;29650 SREBF1_32750;RT1-S3_9763;NREP_9364;GLI2_8713;FGF13_32529;DCC_32537;CXCL10_8408;ADAM10_7983 251.46762500000003 235.11200000000002 56.559954846762906 155.71675 153.26049999999998 26.49914554821949 796.503125 491.1535 614.6937309495653 177.986;219.207;222.026;273.717;209.76;248.198;344.076;316.771 117.256;141.536;142.777;163.744;130.074;183.659;187.725;178.963 348.781;484.566;497.741;831.582;483.266;299.409;2052.67;1374.01 0 Exp 2,3(0.2);Exp 5,1(0.07);Linear,8(0.54);Poly 2,3(0.2) 1.9089342374161375 29.080243349075317 1.5347857475280762 2.8712503910064697 0.3701417324081351 1.9169143438339233 185.76486775808607 277.37067890858054 115.96898847393115 190.5418115260688 318.85266753506266 835.0971991316039 CONFLICT 0.4666666666666667 0.5333333333333333 0.0 GO:0034612 6 response to tumor necrosis factor 76 79 3 3 3 2 2 2 57 77 2411 0.72398 0.55266 0.70513 2.53 362282;29650 pck1;adam10 PCK1_9439;ADAM10_7983 272.3125 272.3125 227.854 62.873813662764384 266.27884642857146 62.29210619059196 163.7655 163.7655 148.568 21.492510614165123 161.70298214285714 21.293662265518154 940.2585 940.2585 506.507 613.4172539996734 881.3922249999999 607.7419278277162 227.854;316.771 148.568;178.963 506.507;1374.01 1 1 1 362282 PCK1_9439 227.854 227.854 148.568 148.568 506.507 506.507 227.854 148.568 506.507 1 29650 ADAM10_7983 316.771 316.771 178.963 178.963 1374.01 1374.01 316.771 178.963 1374.01 0 Exp 2,1(0.5);Linear,1(0.5) 1.8853515887658259 3.8062974214553833 1.6434866189956665 2.162810802459717 0.36721765176159665 1.9031487107276917 185.17383999999998 359.45116 133.97840000000002 193.55259999999998 90.10556000000008 1790.4114399999999 CONFLICT 0.5 0.5 0.0 GO:0048869 3 cellular developmental process 541 573 22 21 21 14 13 13 46 560 1928 0.53947 0.58596 1.0 2.27 246118;360243;78968;362282;25595;24503;24494;304729;80841;25311;25279;24232;298566 tubb3;top2a;srebf1;pck1;map2;ina;il1b;gli2;fabp7;dcc;cyp24a1;c3;c1qa TUBB3_32820;TOP2A_10059;SREBF1_32750;PCK1_9439;MAP2_32650;INA_32322;IL1B_8892;GLI2_8713;FABP7_8592;DCC_32537;CYP24A1_32574;C3_8175;C1QA_8167 219.11146153846155 227.854 144.319 54.76727670731762 228.4255941915596 53.74364520508068 151.16773846153848 148.568 57.6936 55.2227727493157 160.04609270033018 56.25259018233184 418.9433846153847 354.06 153.26 207.18751333817477 430.9721246811774 212.1830936947606 282.273;203.468;177.986;227.854;145.437;305.642;153.991;273.717;227.998;248.198;189.111;144.319;268.455 238.208;108.442;117.256;148.568;104.718;249.176;109.464;163.744;194.92;183.659;127.579;57.6936;161.753 354.06;572.253;348.781;506.507;237.081;459.059;258.668;831.582;274.42;299.409;364.247;153.26;786.937 9 4 9 246118;362282;25595;24503;24494;80841;25279;24232;298566 TUBB3_32820;PCK1_9439;MAP2_32650;INA_32322;IL1B_8892;FABP7_8592;CYP24A1_32574;C3_8175;C1QA_8167 216.12 227.854 61.38923212787401 154.6755111111111 148.568 63.53598997576979 377.1376666666667 354.06 189.21047517381277 282.273;227.854;145.437;305.642;153.991;227.998;189.111;144.319;268.455 238.208;148.568;104.718;249.176;109.464;194.92;127.579;57.6936;161.753 354.06;506.507;237.081;459.059;258.668;274.42;364.247;153.26;786.937 4 360243;78968;304729;25311 TOP2A_10059;SREBF1_32750;GLI2_8713;DCC_32537 225.84224999999998 225.833 43.13775984274107 143.27525 140.5 36.2407398137786 513.00625 460.51700000000005 243.3066678211882 203.468;177.986;273.717;248.198 108.442;117.256;163.744;183.659 572.253;348.781;831.582;299.409 0 Exp 2,6(0.47);Exp 5,1(0.08);Linear,5(0.39);Poly 2,1(0.08) 2.2210003372533507 30.39811098575592 1.5889767408370972 5.283818244934082 0.9485785666268159 2.1256394386291504 189.3396307849164 248.88329229200664 121.14829723899473 181.18717968408217 306.3149693973638 531.5717998334055 UP 0.6923076923076923 0.3076923076923077 0.0 GO:0032310 7 prostaglandin secretion 1 2 1 1 1 1 1 1 58 1 2487 0.99947 0.045801 0.045801 50.0 170924 abcc4 ABCC4_32768 244.652 244.652 244.652 244.652 152.355 152.355 152.355 152.355 619.152 619.152 619.152 619.152 0.0 244.652 0.0 244.652 244.652 152.355 619.152 1 0 1 170924 ABCC4_32768 244.652 244.652 152.355 152.355 619.152 619.152 244.652 152.355 619.152 0 0 Linear,1(1) 1.5415009260177612 1.5415009260177612 1.5415009260177612 1.5415009260177612 0.0 1.5415009260177612 244.652 244.652 152.355 152.355 619.152 619.152 UP 1.0 0.0 0.0 GO:0009314 4 response to radiation 159 166 7 7 6 6 5 5 54 161 2327 0.81697 0.33933 0.58784 3.01 360243;29483;24494;24408;245920 top2a;slc1a3;il1b;grin1;cxcl10 TOP2A_10059;SLC1A3_32817;IL1B_8892;GRIN1_32381;CXCL10_8408 262.99899999999997 303.435 153.991 80.38451145276684 271.36113642202247 83.79896898825122 169.95279999999997 187.725 108.442 61.953965375107394 173.77940749435265 59.25086886949466 864.7072000000001 572.253 258.668 716.7223337525488 986.5432067590912 813.0219328446108 203.468;303.435;153.991;310.025;344.076 108.442;189.179;109.464;254.954;187.725 572.253;992.735;258.668;447.21;2052.67 3 2 3 29483;24494;24408 SLC1A3_32817;IL1B_8892;GRIN1_32381 255.817 303.435 88.24544029013614 184.53233333333333 189.179 72.8562190779438 566.2043333333332 447.21 381.226085999284 303.435;153.991;310.025 189.179;109.464;254.954 992.735;258.668;447.21 2 360243;245920 TOP2A_10059;CXCL10_8408 273.772 273.772 99.42487028907804 148.0835 148.0835 56.06154693281306 1312.4615000000001 1312.4615000000001 1046.8128996838445 203.468;344.076 108.442;187.725 572.253;2052.67 0 Exp 2,3(0.6);Linear,2(0.4) 2.1637110057609013 11.015534162521362 1.6762725114822388 2.8712503910064697 0.4722987046178645 2.0807507038116455 192.53886907697319 333.45913092302686 115.64775500267194 224.25784499732805 236.47237516890766 1492.9420248310926 UP 0.6 0.4 0.0 GO:0017144 4 drug metabolic process 142 165 5 5 5 4 4 4 55 161 2327 0.66537 0.53853 0.7908 2.42 362282;24450;50549;25086 pck1;hmgcs2;cyp4a1;cyp2e1 PCK1_9439;HMGCS2_8812;CYP4A1_33111;CYP2E1_8421 307.57275000000004 313.416 227.854 70.51410374941528 335.18499668089146 62.335313584960154 174.89075 176.9515 148.568 23.33375711103268 184.04357117117118 20.606157040468766 1969.7725 1702.9315 506.507 1624.7428676884022 2596.6176456140347 1513.4668856688288 227.854;269.456;375.605;357.376 148.568;162.134;197.092;191.769 506.507;795.183;3966.72;2610.68 4 0 4 362282;24450;50549;25086 PCK1_9439;HMGCS2_8812;CYP4A1_33111;CYP2E1_8421 307.57275000000004 313.416 70.51410374941528 174.89075 176.9515 23.33375711103268 1969.7725 1702.9315 1624.7428676884022 227.854;269.456;375.605;357.376 148.568;162.134;197.092;191.769 506.507;795.183;3966.72;2610.68 0 0 Exp 2,1(0.25);Linear,3(0.75) 1.8534972439837987 7.460815072059631 1.5810112953186035 2.162810802459717 0.24106843770000871 1.8584964871406555 238.46892832557288 376.67657167442724 152.023668031188 197.75783196881198 377.52448966536576 3562.0205103346343 UP 1.0 0.0 0.0 GO:0051172 6 negative regulation of nitrogen compound metabolic process 471 499 14 14 11 8 6 6 53 493 1995 0.039486 0.98414 0.068249 1.2 311715;78968;681410;24494;304729;24232 tcfl5;srebf1;loc681410;il1b;gli2;c3 TCFL5_9994;SREBF1_32750;LOC681410_33126;IL1B_8892;GLI2_8713;C3_8175 238.5875 224.4535 144.319 101.56810593045428 222.61800586305864 91.88299488647691 167.24843333333334 140.5 57.6936 96.99263030069174 150.55195289872898 86.48821206822112 404.417 343.824 153.26 237.6772741344869 405.41498052480523 254.3052439504468 270.921;177.986;410.591;153.991;273.717;144.319 228.673;117.256;326.66;109.464;163.744;57.6936 338.867;348.781;495.344;258.668;831.582;153.26 4 2 4 311715;681410;24494;24232 TCFL5_9994;LOC681410_33126;IL1B_8892;C3_8175 244.9555 212.45600000000002 124.51448569410177 180.62265000000002 169.0685 120.84542266034187 311.53475000000003 298.76750000000004 144.19741331331147 270.921;410.591;153.991;144.319 228.673;326.66;109.464;57.6936 338.867;495.344;258.668;153.26 2 78968;304729 SREBF1_32750;GLI2_8713 225.8515 225.8515 67.69203926976942 140.5 140.5 32.8719800438003 590.1815 590.1815 341.3918610636464 177.986;273.717 117.256;163.744 348.781;831.582 0 Exp 2,2(0.34);Exp 5,1(0.17);Linear,2(0.34);Poly 2,1(0.17) 1.9519888948865902 11.961494445800781 1.5889767408370972 2.8712503910064697 0.47704205426544183 1.7886574864387512 157.31608900094932 319.85891099905064 89.63816533794561 244.85870132872105 214.23557193887027 594.5984280611298 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0002718 6 regulation of cytokine production involved in immune response 32 36 3 3 3 3 3 3 56 33 2455 0.9912 0.049094 0.049094 8.33 294228;24494;24451 rt1-s3;il1b;hmox1 RT1-S3_9763;IL1B_8892;HMOX1_8815 144.8252 153.991 61.2776 79.36266605476405 161.90704450185694 78.95661854562141 96.92513333333333 109.464 39.7754 52.026169482802906 107.26443087356692 50.761665635191775 294.67266666666666 258.668 140.784 174.69621603610457 337.48568125302756 180.99841145324402 0.5 107.63430000000001 219.207;153.991;61.2776 141.536;109.464;39.7754 484.566;258.668;140.784 2 1 2 24494;24451 IL1B_8892;HMOX1_8815 107.63430000000001 107.63430000000001 65.55827384686086 74.6197 74.6197 49.27728163139686 199.726 199.726 83.35657579339495 153.991;61.2776 109.464;39.7754 258.668;140.784 1 294228 RT1-S3_9763 219.207 219.207 141.536 141.536 484.566 484.566 219.207 141.536 484.566 0 Linear,2(0.67);Poly 2,1(0.34) 2.0133903890748397 6.248745441436768 1.5923793315887451 2.8712503910064697 0.6894861646746159 1.7851157188415527 55.01788904376416 234.63251095623582 38.05198033996267 155.798286326704 96.98528825115284 492.3600450821805 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0008104 4 protein localization 289 309 9 9 8 7 6 6 53 303 2185 0.41359 0.73905 0.83981 1.94 366669;313506;25247;311024;24408;84488 syne2;stil;nsg1;kif5c;grin1;fgf13 SYNE2_9977;STIL_33274;NSG1_32675;KIF5C_8965;GRIN1_32381;FGF13_32529 263.57783333333333 266.78700000000003 209.76 44.27560207345183 264.2893553618263 44.153009840945714 183.61599999999999 171.7395 130.074 43.033232437268786 183.1529475084038 44.752876536560706 631.6820000000001 465.238 342.576 370.559388770545 640.4887356580844 373.1870737963447 276.757;311.636;216.472;256.817;310.025;209.76 164.88;177.242;166.237;208.309;254.954;130.074 858.911;1285.89;342.576;372.239;447.21;483.266 3 3 3 25247;311024;24408 NSG1_32675;KIF5C_8965;GRIN1_32381 261.1046666666667 256.817 46.923650927153396 209.83333333333334 208.309 44.37813894625732 387.3416666666667 372.239 53.92713968247619 216.472;256.817;310.025 166.237;208.309;254.954 342.576;372.239;447.21 3 366669;313506;84488 SYNE2_9977;STIL_33274;FGF13_32529 266.051 276.757 51.77493284399326 157.39866666666668 164.88 24.45777621398411 876.0223333333333 858.911 401.58550725883197 276.757;311.636;209.76 164.88;177.242;130.074 858.911;1285.89;483.266 0 Exp 2,4(0.67);Linear,2(0.34) 2.047386642030815 12.751837968826294 1.6343638896942139 3.437419891357422 0.6944727314997864 1.8328086137771606 228.14997317607305 299.0056934905936 149.18224259172788 218.0497574082721 335.17273551741823 928.1912644825818 CONFLICT 0.5 0.5 0.0 GO:0014070 5 response to organic cyclic compound 433 471 20 20 17 15 13 13 46 458 2030 0.81251 0.2867 0.49672 2.76 78968;79212;362282;25595;24494;24450;24408;304729;25315;25279;245920;24232;170924 srebf1;slc6a1;pck1;map2;il1b;hmgcs2;grin1;gli2;ephx1;cyp24a1;cxcl10;c3;abcc4 SREBF1_32750;SLC6A1_32594;PCK1_9439;MAP2_32650;IL1B_8892;HMGCS2_8812;GRIN1_32381;GLI2_8713;EPHX1_8567;CYP24A1_32574;CXCL10_8408;C3_8175;ABCC4_32768 202.96756923076924 189.111 12.5094 87.89357732249626 212.50278732432 78.12803575850336 130.32266153846152 127.579 3.282 61.31470346490504 136.5670449990203 53.021514957117 531.7568153846154 364.247 61.3966 513.3355540165481 587.7731449687383 594.1322051023479 177.986;145.445;227.854;145.437;153.991;269.456;310.025;273.717;12.5094;189.111;344.076;144.319;244.652 117.256;104.722;148.568;104.718;109.464;162.134;254.954;163.744;3.282;127.579;187.725;57.6936;152.355 348.781;237.101;506.507;237.081;258.668;795.183;447.21;831.582;61.3966;364.247;2052.67;153.26;619.152 10 3 10 79212;362282;25595;24494;24450;24408;25315;25279;24232;170924 SLC6A1_32594;PCK1_9439;MAP2_32650;IL1B_8892;HMGCS2_8812;GRIN1_32381;EPHX1_8567;CYP24A1_32574;C3_8175;ABCC4_32768 184.27994000000004 171.551 84.10968127809458 122.54696000000001 118.5215 66.60542772222426 367.98056 311.4575 225.43337731021896 145.445;227.854;145.437;153.991;269.456;310.025;12.5094;189.111;144.319;244.652 104.722;148.568;104.718;109.464;162.134;254.954;3.282;127.579;57.6936;152.355 237.101;506.507;237.081;258.668;795.183;447.21;61.3966;364.247;153.26;619.152 3 78968;304729;245920 SREBF1_32750;GLI2_8713;CXCL10_8408 265.25966666666665 273.717 83.36736106134902 156.24166666666667 163.744 35.82853254507272 1077.6776666666667 831.582 878.1980066843314 177.986;273.717;344.076 117.256;163.744;187.725 348.781;831.582;2052.67 0 Exp 2,3(0.24);Exp 5,1(0.08);Hill,1(0.08);Linear,8(0.62) 2.031646755694804 26.76769983768463 1.5415009260177612 2.8712503910064697 0.3559698876743466 2.1014184951782227 155.18807633479767 250.74706212674076 96.99160905585649 163.65371402106655 252.70442949309677 810.809201276134 UP 0.7692307692307693 0.23076923076923078 0.0 GO:0044270 5 cellular nitrogen compound catabolic process 51 59 3 3 3 2 2 2 57 57 2431 0.84514 0.39953 0.39953 3.39 24451;316098 hmox1;exosc7 HMOX1_8815;EXOSC7_8580 86.6313 86.6313 61.2776 35.85554639633873 78.00163834522111 33.71465685466897 47.3307 47.3307 39.7754 10.684807727797489 44.75909574893011 10.046831308017342 257.15549999999996 257.15549999999996 140.784 164.57415357370076 217.54602796005705 154.74763802376415 61.2776;111.985 39.7754;54.886 140.784;373.527 2 0 2 24451;316098 HMOX1_8815;EXOSC7_8580 86.6313 86.6313 35.85554639633873 47.3307 47.3307 10.684807727797489 257.15549999999996 257.15549999999996 164.57415357370076 61.2776;111.985 39.7754;54.886 140.784;373.527 0 0 Poly 2,2(1) 1.7508681093257352 3.5175105333328247 1.5923793315887451 1.9251312017440796 0.23529110383934257 1.7587552666664124 36.938048 136.32455199999998 32.522312 62.139088 29.06735999999995 485.24363999999997 UP 1.0 0.0 0.0 GO:0098542 4 defense response to other organism 155 169 10 10 9 6 6 6 53 163 2325 0.90767 0.19375 0.28161 3.55 29142;294228;25211;245920;24232;298566 vnn1;rt1-s3;lyz2;cxcl10;c3;c1qa VNN1_10157;RT1-S3_9763;LYZ2_32611;CXCL10_8408;C3_8175;C1QA_8167 237.4188333333333 226.474 144.319 66.1320424436345 244.53401975981603 65.29513620479248 139.34376666666668 144.6775 57.6936 43.786618080946404 144.33072254492802 40.505552168924 749.7691666666666 520.7085 153.26 669.8925736090576 807.4776576952559 688.0611056331161 233.741;219.207;214.715;344.076;144.319;268.455 147.819;141.536;139.536;187.725;57.6936;161.753 556.851;484.566;464.331;2052.67;153.26;786.937 4 2 4 29142;25211;24232;298566 VNN1_10157;LYZ2_32611;C3_8175;C1QA_8167 215.3075 224.228 52.29457864508191 126.70039999999999 143.6775 46.90902935938883 490.34475 510.591 262.4835791186122 233.741;214.715;144.319;268.455 147.819;139.536;57.6936;161.753 556.851;464.331;153.26;786.937 2 294228;245920 RT1-S3_9763;CXCL10_8408 281.6415 281.6415 88.29571665998316 164.63049999999998 164.63049999999998 32.66055511622566 1268.618 1268.618 1108.81697200575 219.207;344.076 141.536;187.725 484.566;2052.67 0 Exp 5,1(0.17);Linear,5(0.84) 1.894846405404039 11.490604162216187 1.5622447729110718 2.470346212387085 0.31503290349055413 1.8574034571647644 184.50217851923844 290.33548814742824 104.30717519225534 174.38035814107798 213.74347064480935 1285.794862688524 UP 0.6666666666666666 0.3333333333333333 0.0 GO:1905114 6 cell surface receptor signaling pathway involved in cell-cell signaling 34 38 2 2 2 2 2 2 57 36 2452 0.94384 0.21936 0.21936 5.26 304729;24232 gli2;c3 GLI2_8713;C3_8175 209.01799999999997 209.01799999999997 144.319 91.49820327197695 212.02758135006488 91.39915777617814 110.7188 110.7188 57.6936 74.98895698754585 113.18535517092167 74.90778251461995 492.421 492.421 153.26 479.64608602802133 508.1976367373431 479.12687600312705 0.5 209.01799999999997 273.717;144.319 163.744;57.6936 831.582;153.26 1 1 1 24232 C3_8175 144.319 144.319 57.6936 57.6936 153.26 153.26 144.319 57.6936 153.26 1 304729 GLI2_8713 273.717 273.717 163.744 163.744 831.582 831.582 273.717 163.744 831.582 0 Exp 5,1(0.5);Linear,1(0.5) 1.9477064180279768 3.923952341079712 1.7257766723632812 2.1981756687164307 0.3340365337470311 1.961976170539856 82.20795999999999 335.82804 6.789408000000009 214.648192 -172.33455999999995 1157.1765599999999 CONFLICT 0.5 0.5 0.0 GO:0051707 4 response to other organism 231 253 15 15 14 11 11 11 48 242 2246 0.98875 0.027745 0.042595 4.35 29142;294228;362282;25211;24450;304729;25086;245920;502902;24232;298566 vnn1;rt1-s3;pck1;lyz2;hmgcs2;gli2;cyp2e1;cxcl10;clec7a;c3;c1qa VNN1_10157;RT1-S3_9763;PCK1_9439;LYZ2_32611;HMGCS2_8812;GLI2_8713;CYP2E1_8421;CXCL10_8408;CLEC7A_32927;C3_8175;C1QA_8167 269.62736363636367 268.455 144.319 76.22635713619351 276.4338860294118 80.41599059568365 167.35914545454546 161.753 57.6936 66.80813171607728 174.29996670918365 73.58799916046816 884.6647272727273 556.851 153.26 751.1770995436549 889.8084513617947 741.953567944414 233.741;219.207;227.854;214.715;269.456;273.717;357.376;344.076;412.985;144.319;268.455 147.819;141.536;148.568;139.536;162.134;163.744;191.769;187.725;338.673;57.6936;161.753 556.851;484.566;506.507;464.331;795.183;831.582;2610.68;2052.67;488.745;153.26;786.937 8 3 8 29142;362282;25211;24450;25086;502902;24232;298566 VNN1_10157;PCK1_9439;LYZ2_32611;HMGCS2_8812;CYP2E1_8421;CLEC7A_32927;C3_8175;C1QA_8167 266.112625 251.098 84.43442973259117 168.4932 155.1605 78.8563828805615 795.31175 531.679 760.7952256675246 233.741;227.854;214.715;269.456;357.376;412.985;144.319;268.455 147.819;148.568;139.536;162.134;191.769;338.673;57.6936;161.753 556.851;506.507;464.331;795.183;2610.68;488.745;153.26;786.937 3 294228;304729;245920 RT1-S3_9763;GLI2_8713;CXCL10_8408 279.0 273.717 62.6019117679324 164.335 163.744 23.100170800234235 1122.9393333333335 831.582 823.6530583135917 219.207;273.717;344.076 141.536;163.744;187.725 484.566;831.582;2052.67 0 Exp 2,1(0.1);Exp 5,1(0.1);Linear,8(0.73);Poly 2,1(0.1) 1.955046731526306 21.66843855381012 1.5622447729110718 2.470346212387085 0.25498965452196226 1.929691195487976 224.58046522886244 314.6742620438648 127.8780625945576 206.8402283145333 440.74742936584056 1328.5820251796138 UP 0.7272727272727273 0.2727272727272727 0.0 GO:0080134 5 regulation of response to stress 340 358 9 9 8 5 5 5 54 353 2135 0.1429 0.93332 0.2578 1.4 29142;294228;24494;502902;24232 vnn1;rt1-s3;il1b;clec7a;c3 VNN1_10157;RT1-S3_9763;IL1B_8892;CLEC7A_32927;C3_8175 232.84859999999998 219.207 144.319 108.04168569029274 243.74778481566565 112.90460357124431 159.03712000000002 141.536 57.6936 106.57061986482015 170.68579886226888 111.24494272697059 388.418 484.566 153.26 173.07077149680688 398.12378350289896 157.51834933631085 233.741;219.207;153.991;412.985;144.319 147.819;141.536;109.464;338.673;57.6936 556.851;484.566;258.668;488.745;153.26 4 1 4 29142;24494;502902;24232 VNN1_10157;IL1B_8892;CLEC7A_32927;C3_8175 236.25900000000001 193.866 124.44464207563672 163.4124 128.6415 122.53751340157024 364.381 373.7065 189.9635231704585 233.741;153.991;412.985;144.319 147.819;109.464;338.673;57.6936 556.851;258.668;488.745;153.26 1 294228 RT1-S3_9763 219.207 219.207 141.536 141.536 484.566 484.566 219.207 141.536 484.566 0 Exp 5,1(0.2);Linear,3(0.6);Poly 2,1(0.2) 2.0458784573061584 10.411688923835754 1.7257766723632812 2.8712503910064697 0.4640764257630644 1.929691195487976 138.14588698599297 327.55131301400706 65.62385303456531 252.45038696543472 236.71478008580414 540.1212199141959 UP 0.8 0.2 0.0 GO:0034220 5 ion transmembrane transport 134 136 6 6 5 5 4 4 55 132 2356 0.7955 0.38755 0.55414 2.94 79212;29483;84487;24408 slc6a1;slc1a3;slc17a6;grin1 SLC6A1_32594;SLC1A3_32817;SLC17A6_32912;GRIN1_32381 282.134 306.73 145.445 95.8666577630964 274.56690406189557 110.1138372369188 178.07625000000002 176.3145 104.722 62.25815257123622 162.85912820116053 59.586157269750984 532.28775 449.6575 237.101 322.91091875353186 458.24379334622824 278.88581277434133 145.445;303.435;369.631;310.025 104.722;189.179;163.45;254.954 237.101;992.735;452.105;447.21 4 0 4 79212;29483;84487;24408 SLC6A1_32594;SLC1A3_32817;SLC17A6_32912;GRIN1_32381 282.134 306.73 95.8666577630964 178.07625000000002 176.3145 62.25815257123622 532.28775 449.6575 322.91091875353186 145.445;303.435;369.631;310.025 104.722;189.179;163.45;254.954 237.101;992.735;452.105;447.21 0 0 Exp 2,2(0.5);Hill,1(0.25);Linear,1(0.25) 1.8618790331348405 7.463246703147888 1.6762725114822388 2.0017645359039307 0.13787183191804736 1.8926048278808594 188.18467539216547 376.0833246078346 117.06326048018846 239.08923951981157 215.83504962153893 848.7404503784612 UP 1.0 0.0 0.0 GO:0008654 5 phospholipid biosynthetic process 31 34 2 2 2 2 2 2 57 32 2456 0.9575 0.18526 0.18526 5.88 303872;24450 pigz;hmgcs2 PIGZ_32744;HMGCS2_8812 312.2765 312.2765 269.456 60.557331847596956 338.7730972492359 47.57153675175467 187.307 187.307 162.134 35.59999800561807 202.88362434009449 27.966004475704892 627.3865 627.3865 459.59 237.30008601873718 523.5568791330925 186.41392245690363 0.5 312.2765 355.097;269.456 212.48;162.134 459.59;795.183 2 0 2 303872;24450 PIGZ_32744;HMGCS2_8812 312.2765 312.2765 60.557331847596956 187.307 187.307 35.59999800561807 627.3865 627.3865 237.30008601873718 355.097;269.456 212.48;162.134 459.59;795.183 0 0 Linear,1(0.5);Poly 2,1(0.5) 1.8764212810055418 3.753367781639099 1.8452895879745483 1.9080781936645508 0.04439824886464897 1.8766838908195496 228.34832000000006 396.20467999999994 137.96792 236.64607999999998 298.50535999999994 956.26764 UP 1.0 0.0 0.0 GO:0030335 7 positive regulation of cell migration 186 194 11 11 9 9 7 7 52 187 2301 0.92447 0.15797 0.21079 3.61 366669;24494;24451;24408;245920;502902;29650 syne2;il1b;hmox1;grin1;cxcl10;clec7a;adam10 SYNE2_9977;IL1B_8892;HMOX1_8815;GRIN1_32381;CXCL10_8408;CLEC7A_32927;ADAM10_7983 267.9832285714286 310.025 61.2776 120.2509909105357 274.372056439394 128.05985875856265 182.06205714285716 178.963 39.7754 96.34407923560319 191.37667971311475 105.29028594979015 802.9997142857144 488.745 140.784 689.3261993818586 794.1056669461002 749.1490951899353 276.757;153.991;61.2776;310.025;344.076;412.985;316.771 164.88;109.464;39.7754;254.954;187.725;338.673;178.963 858.911;258.668;140.784;447.21;2052.67;488.745;1374.01 4 3 4 24494;24451;24408;502902 IL1B_8892;HMOX1_8815;GRIN1_32381;CLEC7A_32927 234.56965 232.00799999999998 157.10781901640036 185.7166 182.209 135.77281358200298 333.85175000000004 352.93899999999996 163.06416333532619 153.991;61.2776;310.025;412.985 109.464;39.7754;254.954;338.673 258.668;140.784;447.21;488.745 3 366669;245920;29650 SYNE2_9977;CXCL10_8408;ADAM10_7983 312.5346666666667 316.771 33.858851580249464 177.18933333333334 178.963 11.525316756312437 1428.5303333333334 1374.01 598.7440918959722 276.757;344.076;316.771 164.88;187.725;178.963 858.911;2052.67;1374.01 0 Exp 2,1(0.15);Linear,4(0.58);Poly 2,2(0.29) 2.005889888152541 14.342934727668762 1.5923793315887451 2.8712503910064697 0.4720139610833762 1.9169143438339233 178.90004785108619 357.066409291771 110.68936443660289 253.43474984911137 292.3397194713116 1313.659709100117 CONFLICT 0.5714285714285714 0.42857142857142855 0.0 GO:0042369 6 vitamin D catabolic process 1 1 1 1 1 1 1 1 58 0 2488 1.0 0.023165 0.023165 100.0 25279 cyp24a1 CYP24A1_32574 189.111 189.111 189.111 189.111 127.579 127.579 127.579 127.579 364.247 364.247 364.247 364.247 0.0 189.111 0.0 189.111 189.111 127.579 364.247 1 0 1 25279 CYP24A1_32574 189.111 189.111 127.579 127.579 364.247 364.247 189.111 127.579 364.247 0 0 Linear,1(1) 2.1550474166870117 2.1550474166870117 2.1550474166870117 2.1550474166870117 0.0 2.1550474166870117 189.111 189.111 127.579 127.579 364.247 364.247 UP 1.0 0.0 0.0 GO:0032787 7 monocarboxylic acid metabolic process 180 207 13 12 12 11 11 11 48 196 2292 0.9978 0.0067148 0.0067148 5.31 29142;286989;29483;362282;497009;25315;171142;29740;50549;25086;24232 vnn1;ugt2b7;slc1a3;pck1;naaa;ephx1;ehhadh;eci1;cyp4a1;cyp2e1;c3 VNN1_10157;UGT2B7_33032;SLC1A3_32817;PCK1_9439;NAAA_32484;EPHX1_8567;EHHADH_8534;ECI1_8520;CYP4A1_33111;CYP2E1_8421;C3_8175 205.12991545454545 227.854 4.13867 122.28290156536612 214.89931048676135 112.93316419394995 121.17766181818182 147.819 1.39768 71.20465725948296 127.42768841307486 64.40187238128503 921.8759272727272 506.507 16.5686 1241.0088510767787 958.0509337603597 1258.5255391069738 9.5 366.4905 233.741;4.13867;303.435;227.854;151.002;12.5094;250.691;195.758;375.605;357.376;144.319 147.819;1.39768;189.179;148.568;107.821;3.282;157.555;130.778;197.092;191.769;57.6936 556.851;16.5686;992.735;506.507;250.969;61.3966;636.947;388.001;3966.72;2610.68;153.26 11 0 11 29142;286989;29483;362282;497009;25315;171142;29740;50549;25086;24232 VNN1_10157;UGT2B7_33032;SLC1A3_32817;PCK1_9439;NAAA_32484;EPHX1_8567;EHHADH_8534;ECI1_8520;CYP4A1_33111;CYP2E1_8421;C3_8175 205.12991545454545 227.854 122.28290156536612 121.17766181818182 147.819 71.20465725948296 921.8759272727272 506.507 1241.0088510767787 233.741;4.13867;303.435;227.854;151.002;12.5094;250.691;195.758;375.605;357.376;144.319 147.819;1.39768;189.179;148.568;107.821;3.282;157.555;130.778;197.092;191.769;57.6936 556.851;16.5686;992.735;506.507;250.969;61.3966;636.947;388.001;3966.72;2610.68;153.26 0 0 Exp 2,3(0.28);Exp 5,1(0.1);Hill,2(0.19);Linear,5(0.46) 1.9277689539332232 21.83994686603546 1.5261523723602295 3.570159435272217 0.5743121232025264 1.8089147806167603 132.8653385976515 277.3944923114394 79.09839839519101 163.25692524117267 188.48656252343937 1655.2652920220148 UP 1.0 0.0 0.0 GO:0055114 3 oxidation-reduction process 260 296 12 12 11 8 8 8 51 288 2200 0.75898 0.3779 0.67914 2.7 24451;171142;29740;50549;25086;25279;64564;286921 hmox1;ehhadh;eci1;cyp4a1;cyp2e1;cyp24a1;bbox1;akr1b8 HMOX1_8815;EHHADH_8534;ECI1_8520;CYP4A1_33111;CYP2E1_8421;CYP24A1_32574;BBOX1_8133;AKR1B8_8013 272.74845 274.306 61.2776 125.04070191886666 243.06519064143643 115.47144579980635 164.5478 174.662 39.7754 66.78285699557507 146.95397636781334 59.70829310771006 1159.964125 564.059 140.784 1373.2317306677326 1094.4345852125023 1361.0592258946233 61.2776;250.691;195.758;375.605;357.376;189.111;454.248;297.921 39.7754;157.555;130.778;197.092;191.769;127.579;259.457;212.377 140.784;636.947;388.001;3966.72;2610.68;364.247;491.171;681.163 8 0 8 24451;171142;29740;50549;25086;25279;64564;286921 HMOX1_8815;EHHADH_8534;ECI1_8520;CYP4A1_33111;CYP2E1_8421;CYP24A1_32574;BBOX1_8133;AKR1B8_8013 272.74845 274.306 125.04070191886666 164.5478 174.662 66.78285699557507 1159.964125 564.059 1373.2317306677326 61.2776;250.691;195.758;375.605;357.376;189.111;454.248;297.921 39.7754;157.555;130.778;197.092;191.769;127.579;259.457;212.377 140.784;636.947;388.001;3966.72;2610.68;364.247;491.171;681.163 0 0 Exp 2,2(0.25);Linear,4(0.5);Poly 2,1(0.13);Power,1(0.13) 1.8113114011558973 14.781158924102783 1.5261523723602295 2.7777180671691895 0.4262224158280444 1.6699678301811218 186.09966431386675 359.39723568613323 118.26964117238907 210.82595882761092 208.36308548222166 2111.565164517778 UP 1.0 0.0 0.0 GO:0046173 6 polyol biosynthetic process 14 16 2 2 2 2 2 2 57 14 2474 0.99466 0.051414 0.051414 12.5 362282;25315 pck1;ephx1 PCK1_9439;EPHX1_8567 120.1817 120.1817 12.5094 152.2716269519046 137.2697735222672 150.34175687803832 75.92500000000001 75.92500000000001 3.282 102.73271581146875 87.45376761133603 101.43069521958147 283.9518 283.9518 61.3966 314.74058221665666 319.2723013765182 310.7516025044807 0.0 12.5094 0.5 120.1817 227.854;12.5094 148.568;3.282 506.507;61.3966 2 0 2 362282;25315 PCK1_9439;EPHX1_8567 120.1817 120.1817 152.2716269519046 75.92500000000001 75.92500000000001 102.73271581146875 283.9518 283.9518 314.74058221665666 227.854;12.5094 148.568;3.282 506.507;61.3966 0 0 Exp 2,1(0.5);Hill,1(0.5) 2.1318936703926163 4.2642292976379395 2.1014184951782227 2.162810802459717 0.04341091679143277 2.1321146488189697 -90.85600799999997 331.219408 -66.45527999999999 218.30528 -152.256392 720.159992 UP 1.0 0.0 0.0 GO:0001934 9 positive regulation of protein phosphorylation 270 289 10 10 8 6 5 5 54 284 2204 0.32447 0.81706 0.67658 1.73 313506;24494;84488;25311;24232 stil;il1b;fgf13;dcc;c3 STIL_33274;IL1B_8892;FGF13_32529;DCC_32537;C3_8175 213.5808 209.76 144.319 69.23855952213337 216.01395192636826 66.44442358871541 131.62652 130.074 57.6936 51.83583524312112 135.04981414064582 50.017939848533636 496.0986000000001 299.409 153.26 457.3110334748113 493.17407644620243 440.49810602549854 311.636;153.991;209.76;248.198;144.319 177.242;109.464;130.074;183.659;57.6936 1285.89;258.668;483.266;299.409;153.26 2 3 2 24494;24232 IL1B_8892;C3_8175 149.155 149.155 6.839136787636285 83.5788 83.5788 36.607200904740054 205.964 205.964 74.5347115913116 153.991;144.319 109.464;57.6936 258.668;153.26 3 313506;84488;25311 STIL_33274;FGF13_32529;DCC_32537 256.53133333333335 248.198 51.44670229794449 163.65833333333333 177.242 29.261323557442324 689.5216666666666 483.266 524.587686535181 311.636;209.76;248.198 177.242;130.074;183.659 1285.89;483.266;299.409 0 Exp 2,1(0.2);Exp 5,1(0.2);Linear,2(0.4);Poly 2,1(0.2) 1.9195341849018432 9.829241275787354 1.6343638896942139 2.8712503910064697 0.519477006854741 1.7257766723632812 152.89052670378305 274.27107329621697 86.19040710055353 177.06263289944653 95.2478053775389 896.9493946224611 DOWN 0.4 0.6 0.0 GO:1901565 5 organonitrogen compound catabolic process 128 143 3 3 3 2 2 2 57 141 2347 0.34632 0.85405 0.77139 1.4 365377;24451 trim72;hmox1 TRIM72_33144;HMOX1_8815 71.6852 71.6852 61.2776 14.718569071754247 74.19442267991278 14.2843928329216 44.540499999999994 44.540499999999994 39.7754 6.738869046064074 45.68934286406591 6.540082275275281 167.1255 167.1255 140.784 37.25250655325102 173.47630991034652 36.15361214962181 82.0928;61.2776 49.3056;39.7754 193.467;140.784 2 0 2 365377;24451 TRIM72_33144;HMOX1_8815 71.6852 71.6852 14.718569071754247 44.540499999999994 44.540499999999994 6.738869046064074 167.1255 167.1255 37.25250655325102 82.0928;61.2776 49.3056;39.7754 193.467;140.784 0 0 Poly 2,2(1) 1.6288293570808328 3.2584930658340454 1.5923793315887451 1.6661137342453003 0.05213809612518955 1.6292465329170227 51.286304 92.08409599999999 35.200903999999994 53.880095999999995 115.49615999999997 218.75484 UP 1.0 0.0 0.0 GO:1903428 7 positive regulation of reactive oxygen species biosynthetic process 30 33 3 3 3 3 3 3 56 30 2458 0.99356 0.039381 0.039381 9.09 24494;24408;502902 il1b;grin1;clec7a IL1B_8892;GRIN1_32381;CLEC7A_32927 292.33366666666666 310.025 153.991 130.40019350190138 304.58781211589115 133.87185303768982 234.36366666666666 254.954 109.464 115.98345912384804 244.7577699109494 118.66761250473938 398.2076666666667 447.21 258.668 122.6163854724699 406.05222695346794 122.80636546628763 0.5 232.00799999999998 153.991;310.025;412.985 109.464;254.954;338.673 258.668;447.21;488.745 3 0 3 24494;24408;502902 IL1B_8892;GRIN1_32381;CLEC7A_32927 292.33366666666666 310.025 130.40019350190138 234.36366666666666 254.954 115.98345912384804 398.2076666666667 447.21 122.6163854724699 153.991;310.025;412.985 109.464;254.954;338.673 258.668;447.21;488.745 0 0 Exp 2,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 2.260932985745527 6.888019680976868 1.9169143438339233 2.8712503910064697 0.5065036175043436 2.0998549461364746 144.7719564980906 439.8953768352427 103.11602722713928 365.61130610619404 259.45416447387134 536.9611688594618 UP 1.0 0.0 0.0 GO:1901137 5 carbohydrate derivative biosynthetic process 71 78 2 2 2 2 2 2 57 76 2412 0.73036 0.54566 0.70186 2.56 303872;24494 pigz;il1b PIGZ_32744;IL1B_8892 254.54399999999998 254.54399999999998 153.991 142.20341633730186 262.74840796435535 141.72927360961398 160.97199999999998 160.97199999999998 109.464 72.84331217071349 165.17468560289612 72.60043385164045 359.129 359.129 258.668 142.07330868956333 367.32590142021724 141.59959977420274 355.097;153.991 212.48;109.464 459.59;258.668 2 0 2 303872;24494 PIGZ_32744;IL1B_8892 254.54399999999998 254.54399999999998 142.20341633730186 160.97199999999998 160.97199999999998 72.84331217071349 359.129 359.129 142.07330868956333 355.097;153.991 212.48;109.464 459.59;258.668 0 0 Linear,1(0.5);Poly 2,1(0.5) 2.301801131938224 4.716539978981018 1.8452895879745483 2.8712503910064697 0.7254638410554675 2.358269989490509 57.46012000000002 451.62787999999995 60.01631999999999 261.92767999999995 162.22544000000008 556.03256 UP 1.0 0.0 0.0 GO:0010866 7 regulation of triglyceride biosynthetic process 13 13 2 2 2 2 2 2 57 11 2477 0.99714 0.034931 0.034931 15.38 78968;24232 srebf1;c3 SREBF1_32750;C3_8175 161.15249999999997 161.15249999999997 144.319 23.806164002207833 161.38232173231873 23.80394522852644 87.4748 87.4748 57.6936 42.11697694374561 87.8813920322292 42.11305157215103 251.0205 251.0205 153.26 138.25422496437506 252.3551890107431 138.2413394429799 0.0 144.319 0.5 161.15249999999997 177.986;144.319 117.256;57.6936 348.781;153.26 1 1 1 24232 C3_8175 144.319 144.319 57.6936 57.6936 153.26 153.26 144.319 57.6936 153.26 1 78968 SREBF1_32750 177.986 177.986 117.256 117.256 348.781 348.781 177.986 117.256 348.781 0 Exp 2,1(0.5);Exp 5,1(0.5) 1.655964671200596 3.3147534132003784 1.5889767408370972 1.7257766723632812 0.09673215924802013 1.6573767066001892 128.15883999999997 194.14615999999998 29.103648 145.845952 59.40992 442.63108 CONFLICT 0.5 0.5 0.0 GO:0021766 4 hippocampus development 31 35 2 2 2 2 2 2 57 33 2455 0.95426 0.19371 0.19371 5.71 84487;84488 slc17a6;fgf13 SLC17A6_32912;FGF13_32529 289.6955 289.6955 209.76 113.04586821507446 305.45369813071727 110.82746367144782 146.762 146.762 130.074 23.60039592888227 150.05181254142914 23.137263340432153 467.68550000000005 467.68550000000005 452.105 22.034154408552816 464.61401604136285 21.601757638760088 0.5 289.6955 369.631;209.76 163.45;130.074 452.105;483.266 1 1 1 84487 SLC17A6_32912 369.631 369.631 163.45 163.45 452.105 452.105 369.631 163.45 452.105 1 84488 FGF13_32529 209.76 209.76 130.074 130.074 483.266 483.266 209.76 130.074 483.266 0 Exp 2,1(0.5);Hill,1(0.5) 1.7631716934439683 3.53225839138031 1.6639630794525146 1.8682953119277954 0.14448470719825712 1.766129195690155 133.02192000000002 446.36907999999994 114.05352000000002 179.47047999999998 437.14772000000005 498.22328000000005 CONFLICT 0.5 0.5 0.0 GO:0003008 3 system process 296 309 14 14 13 11 10 10 49 299 2189 0.90646 0.17035 0.23004 3.24 365377;79212;29483;288280;24584;24494;24416;24408;84488;80841 trim72;slc6a1;slc1a3;ncam2;mylpf;il1b;grm3;grin1;fgf13;fabp7 TRIM72_33144;SLC6A1_32594;SLC1A3_32817;NCAM2_32618;MYLPF_32295;IL1B_8892;GRM3_33234;GRIN1_32381;FGF13_32529;FABP7_8592 238.73768 257.49199999999996 82.0928 89.32315679599438 225.58931769262549 91.26345319051022 173.67316 192.0495 49.3056 72.01576356874475 168.17539781381257 78.51537539385185 588.358 389.67650000000003 193.467 615.9897155169612 469.420127797287 472.11318322554973 82.0928;145.445;303.435;314.433;353.211;153.991;286.986;310.025;209.76;227.998 49.3056;104.722;189.179;261.826;200.468;109.464;241.819;254.954;130.074;194.92 193.467;237.101;992.735;415.493;2217.36;258.668;363.86;447.21;483.266;274.42 9 1 9 365377;79212;29483;288280;24584;24494;24416;24408;80841 TRIM72_33144;SLC6A1_32594;SLC1A3_32817;NCAM2_32618;MYLPF_32295;IL1B_8892;GRM3_33234;GRIN1_32381;FABP7_8592 241.9574222222222 286.986 94.12400760568185 178.5175111111111 194.92 74.63606319133606 600.0348888888889 363.86 652.1808118279862 82.0928;145.445;303.435;314.433;353.211;153.991;286.986;310.025;227.998 49.3056;104.722;189.179;261.826;200.468;109.464;241.819;254.954;194.92 193.467;237.101;992.735;415.493;2217.36;258.668;363.86;447.21;274.42 1 84488 FGF13_32529 209.76 209.76 130.074 130.074 483.266 483.266 209.76 130.074 483.266 0 Exp 2,7(0.7);Linear,2(0.2);Poly 2,1(0.1) 2.207634108100019 24.07961595058441 1.601873517036438 5.283818244934082 1.2123119081519276 1.8233880996704102 183.37461383874876 294.10074616125127 129.0373272985718 218.3089927014282 206.5636188105389 970.1523811894613 UP 0.9 0.1 0.0 GO:0007612 6 learning 40 43 4 4 3 4 3 3 56 40 2448 0.98365 0.075812 0.075812 6.98 79212;24408;84488 slc6a1;grin1;fgf13 SLC6A1_32594;GRIN1_32381;FGF13_32529 221.74333333333334 209.76 145.445 82.94181278663562 203.3047632020117 78.69779271571983 163.25 130.074 104.722 80.42324718637019 146.95479128248112 73.0409427154667 389.19233333333335 447.21 237.101 132.94299169318168 363.0172162615256 141.8655083549702 1.5 259.8925 145.445;310.025;209.76 104.722;254.954;130.074 237.101;447.21;483.266 2 1 2 79212;24408 SLC6A1_32594;GRIN1_32381 227.73499999999999 227.73499999999999 116.37563404768197 179.838 179.838 106.23006595121745 342.15549999999996 342.15549999999996 148.56949868832447 145.445;310.025 104.722;254.954 237.101;447.21 1 84488 FGF13_32529 209.76 209.76 130.074 130.074 483.266 483.266 209.76 130.074 483.266 0 Exp 2,2(0.67);Linear,1(0.34) 1.8551817409956726 5.582641959190369 1.6639630794525146 2.0017645359039307 0.17573356785541777 1.9169143438339233 127.88583657203152 315.6008300946351 72.24252851217692 254.25747148782312 238.7531761331055 539.6314905335611 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0045597 6 positive regulation of cell differentiation 285 303 10 10 8 7 6 6 53 297 2191 0.43557 0.72093 0.83945 1.98 29142;24494;24408;304729;25311;502902 vnn1;il1b;grin1;gli2;dcc;clec7a VNN1_10157;IL1B_8892;GRIN1_32381;GLI2_8713;DCC_32537;CLEC7A_32927 272.1095 260.9575 153.991 86.35039937776762 281.9304030697706 93.16870127466952 199.71883333333335 173.7015 109.464 83.36764191319466 210.63294899668406 88.98938039062381 480.41083333333336 467.97749999999996 258.668 206.0425144725395 467.3613419136499 207.6133134311835 233.741;153.991;310.025;273.717;248.198;412.985 147.819;109.464;254.954;163.744;183.659;338.673 556.851;258.668;447.21;831.582;299.409;488.745 4 2 4 29142;24494;24408;502902 VNN1_10157;IL1B_8892;GRIN1_32381;CLEC7A_32927 277.68550000000005 271.883 110.4283272398888 212.72750000000002 201.3865 104.11821818970968 437.86850000000004 467.97749999999996 127.73062329371106 233.741;153.991;310.025;412.985 147.819;109.464;254.954;338.673 556.851;258.668;447.21;488.745 2 304729;25311 GLI2_8713;DCC_32537 260.9575 260.9575 18.044657949100255 173.7015 173.7015 14.082031547329832 565.4955 565.4955 376.30313706438864 273.717;248.198 163.744;183.659 831.582;299.409 0 Exp 2,1(0.17);Linear,3(0.5);Poly 2,2(0.34) 2.135374596007022 12.949773788452148 1.9169143438339233 2.8712503910064697 0.3672041010349349 2.0168710947036743 203.01479026338274 341.2042097366172 133.01082664284542 266.4268400238212 315.5424849126049 645.2791817540618 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0048565 5 digestive tract development 26 28 2 2 2 2 2 2 57 26 2462 0.97435 0.13601 0.13601 7.14 24450;304729 hmgcs2;gli2 HMGCS2_8812;GLI2_8713 271.5865 271.5865 269.456 3.012981994641311 272.77544870349493 2.500172486234375 162.939 162.939 162.134 1.1384419177091094 163.38823900789174 0.9446791135587761 813.3824999999999 813.3824999999999 795.183 25.73797972841824 823.5389289740699 21.357375809992124 0.5 271.5865 269.456;273.717 162.134;163.744 795.183;831.582 1 1 1 24450 HMGCS2_8812 269.456 269.456 162.134 162.134 795.183 795.183 269.456 162.134 795.183 1 304729 GLI2_8713 273.717 273.717 163.744 163.744 831.582 831.582 273.717 163.744 831.582 0 Linear,2(1) 2.047996840652303 4.1062538623809814 1.9080781936645508 2.1981756687164307 0.20512989181427957 2.0531269311904907 267.41072 275.76228 161.36119999999997 164.51680000000002 777.7114799999999 849.0535199999999 CONFLICT 0.5 0.5 0.0 GO:0051716 3 cellular response to stimulus 785 838 30 30 25 20 17 17 42 821 1667 0.3 0.79127 0.57593 2.03 360243;78968;362282;338475;24567;316273;25595;361680;24503;24494;24451;24450;24408;304729;25315;245920;502902 top2a;srebf1;pck1;nrep;mt1;mcm3;map2;lsp1;ina;il1b;hmox1;hmgcs2;grin1;gli2;ephx1;cxcl10;clec7a TOP2A_10059;SREBF1_32750;PCK1_9439;NREP_9364;MT1A_9255;MCM3_9207;MAP2_32650;LSP1_32853;INA_32322;IL1B_8892;HMOX1_8815;HMGCS2_8812;GRIN1_32381;GLI2_8713;EPHX1_8567;CXCL10_8408;CLEC7A_32927 233.7547647058824 229.093 12.5094 106.2184741241426 258.1426327485204 104.09021251729719 153.9472588235294 142.777 3.282 79.95275677135109 170.9869120250591 82.82695634969643 911.9967411764707 497.741 61.3966 1532.1878945770861 1064.33384419981 1651.9159393629043 203.468;177.986;227.854;222.026;392.753;229.093;145.437;231.535;305.642;153.991;61.2776;269.456;310.025;273.717;12.5094;344.076;412.985 108.442;117.256;148.568;142.777;211.395;133.518;104.718;141.502;249.176;109.464;39.7754;162.134;254.954;163.744;3.282;187.725;338.673 572.253;348.781;506.507;497.741;6610.49;614.889;237.081;580.905;459.059;258.668;140.784;795.183;447.21;831.582;61.3966;2052.67;488.745 10 7 10 362282;24567;25595;24503;24494;24451;24450;24408;25315;502902 PCK1_9439;MT1A_9255;MAP2_32650;INA_32322;IL1B_8892;HMOX1_8815;HMGCS2_8812;GRIN1_32381;EPHX1_8567;CLEC7A_32927 229.19299999999998 248.65500000000003 134.3090586773324 162.21394 155.351 103.41115892501047 1000.51236 453.1345 1982.520937147361 227.854;392.753;145.437;305.642;153.991;61.2776;269.456;310.025;12.5094;412.985 148.568;211.395;104.718;249.176;109.464;39.7754;162.134;254.954;3.282;338.673 506.507;6610.49;237.081;459.059;258.668;140.784;795.183;447.21;61.3966;488.745 7 360243;78968;338475;316273;361680;304729;245920 TOP2A_10059;SREBF1_32750;NREP_9364;MCM3_9207;LSP1_32853;GLI2_8713;CXCL10_8408 240.2715714285714 229.093 54.25578368204069 142.13771428571428 141.502 27.001991782794335 785.5458571428571 580.905 577.0346006813423 203.468;177.986;222.026;229.093;231.535;273.717;344.076 108.442;117.256;142.777;133.518;141.502;163.744;187.725 572.253;348.781;497.741;614.889;580.905;831.582;2052.67 0 Exp 2,8(0.48);Hill,1(0.06);Linear,6(0.36);Poly 2,2(0.12) 1.9660973648894982 33.857001423835754 1.5347857475280762 2.8712503910064697 0.339158759852071 1.9169143438339233 183.2617072421575 284.2478221696072 115.94013082317105 191.95438682388777 183.6408497551314 1640.3526325978096 CONFLICT 0.5882352941176471 0.4117647058823529 0.0 GO:0034764 6 positive regulation of transmembrane transport 60 63 2 2 2 2 2 2 57 61 2427 0.82235 0.43218 0.65642 3.17 245920;24232 cxcl10;c3 CXCL10_8408;C3_8175 244.1975 244.1975 144.319 141.24952928948122 264.5090170824296 138.29791781556335 122.7093 122.7093 57.6936 91.94608470718042 135.9310394251627 90.02473941159835 1102.9650000000001 1102.9650000000001 153.26 1343.08569125354 1296.0991513015185 1315.0199896777553 344.076;144.319 187.725;57.6936 2052.67;153.26 1 1 1 24232 C3_8175 144.319 144.319 57.6936 57.6936 153.26 153.26 144.319 57.6936 153.26 1 245920 CXCL10_8408 344.076 344.076 187.725 187.725 2052.67 2052.67 344.076 187.725 2052.67 0 Exp 5,1(0.5);Linear,1(0.5) 2.064767751103891 4.196122884750366 1.7257766723632812 2.470346212387085 0.5264901708157801 2.098061442375183 48.43564000000001 439.95935999999995 -4.7214719999999915 250.14007199999998 -758.4567999999997 2964.3868 CONFLICT 0.5 0.5 0.0 GO:0007613 6 memory 40 41 4 4 4 3 3 3 56 38 2450 0.98611 0.067623 0.067623 7.32 24494;24408;84488 il1b;grin1;fgf13 IL1B_8892;GRIN1_32381;FGF13_32529 224.59199999999998 209.76 153.991 79.06733495571986 220.16346106730956 74.8984897933614 164.83066666666667 130.074 109.464 78.72645319924767 158.77804965139768 74.77166129771098 396.3813333333333 447.21 258.668 120.61811811387753 400.66265276601297 121.27464146550973 1.5 259.8925 153.991;310.025;209.76 109.464;254.954;130.074 258.668;447.21;483.266 2 1 2 24494;24408 IL1B_8892;GRIN1_32381 232.00799999999998 232.00799999999998 110.3326994956618 182.209 182.209 102.8769655948308 352.93899999999996 352.93899999999996 133.31932673847408 153.991;310.025 109.464;254.954 258.668;447.21 1 84488 FGF13_32529 209.76 209.76 130.074 130.074 483.266 483.266 209.76 130.074 483.266 0 Exp 2,2(0.67);Linear,1(0.34) 2.0922126330240336 6.452127814292908 1.6639630794525146 2.8712503910064697 0.6366951501993517 1.9169143438339233 135.1188876432493 314.06511235675066 75.74329833068364 253.9180350026497 259.8890835274344 532.8735831392322 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0043085 5 positive regulation of catalytic activity 340 363 11 11 8 6 5 5 54 358 2130 0.13369 0.93843 0.25782 1.38 313506;24494;24408;84488;502902 stil;il1b;grin1;fgf13;clec7a STIL_33274;IL1B_8892;GRIN1_32381;FGF13_32529;CLEC7A_32927 279.6794 310.025 153.991 100.49721277876326 284.5175222160253 104.37227798506066 202.08139999999997 177.242 109.464 94.64779613282079 206.65107451199108 99.40359020301278 592.7558000000001 483.266 258.668 398.76042934223045 583.5072495631159 381.8504000951765 311.636;153.991;310.025;209.76;412.985 177.242;109.464;254.954;130.074;338.673 1285.89;258.668;447.21;483.266;488.745 3 2 3 24494;24408;502902 IL1B_8892;GRIN1_32381;CLEC7A_32927 292.33366666666666 310.025 130.40019350190138 234.36366666666666 254.954 115.98345912384804 398.2076666666667 447.21 122.6163854724699 153.991;310.025;412.985 109.464;254.954;338.673 258.668;447.21;488.745 2 313506;84488 STIL_33274;FGF13_32529 260.698 260.698 72.0372104401611 153.65800000000002 153.65800000000002 33.35281265500693 884.5780000000001 884.5780000000001 567.5408731430714 311.636;209.76 177.242;130.074 1285.89;483.266 0 Exp 2,2(0.4);Linear,2(0.4);Poly 2,1(0.2) 1.9928339021164172 10.186346650123596 1.6343638896942139 2.8712503910064697 0.5038891352980129 1.9169143438339233 191.5897090655506 367.76909093444937 119.11894881917667 285.04385118082337 243.22687271547807 942.2847272845218 UP 0.6 0.4 0.0 GO:0048583 4 regulation of response to stimulus 781 832 28 26 23 17 15 15 44 817 1671 0.14409 0.9124 0.26265 1.8 29142;365377;294228;338475;24494;24451;24408;304729;80841;25311;245920;502902;24232;298566;29650 vnn1;trim72;rt1-s3;nrep;il1b;hmox1;grin1;gli2;fabp7;dcc;cxcl10;clec7a;c3;c1qa;adam10 VNN1_10157;TRIM72_33144;RT1-S3_9763;NREP_9364;IL1B_8892;HMOX1_8815;GRIN1_32381;GLI2_8713;FABP7_8592;DCC_32537;CXCL10_8408;CLEC7A_32927;C3_8175;C1QA_8167;ADAM10_7983 234.59196000000003 233.741 61.2776 95.42961372542591 233.30898276358215 102.1579655281452 156.8507733333333 161.753 39.7754 77.56549031786409 156.93390472143028 83.51949980466179 589.3546666666666 484.566 140.784 517.285048241526 580.4179430071141 536.2433660029328 233.741;82.0928;219.207;222.026;153.991;61.2776;310.025;273.717;227.998;248.198;344.076;412.985;144.319;268.455;316.771 147.819;49.3056;141.536;142.777;109.464;39.7754;254.954;163.744;194.92;183.659;187.725;338.673;57.6936;161.753;178.963 556.851;193.467;484.566;497.741;258.668;140.784;447.21;831.582;274.42;299.409;2052.67;488.745;153.26;786.937;1374.01 9 6 9 29142;365377;24494;24451;24408;80841;502902;24232;298566 VNN1_10157;TRIM72_33144;IL1B_8892;HMOX1_8815;GRIN1_32381;FABP7_8592;CLEC7A_32927;C3_8175;C1QA_8167 210.5427111111111 227.998 112.60518197303851 150.48417777777777 147.819 100.76202953952665 366.7046666666667 274.42 218.2098294268615 233.741;82.0928;153.991;61.2776;310.025;227.998;412.985;144.319;268.455 147.819;49.3056;109.464;39.7754;254.954;194.92;338.673;57.6936;161.753 556.851;193.467;258.668;140.784;447.21;274.42;488.745;153.26;786.937 6 294228;338475;304729;25311;245920;29650 RT1-S3_9763;NREP_9364;GLI2_8713;DCC_32537;CXCL10_8408;ADAM10_7983 270.66583333333335 260.9575 51.07386226012938 166.40066666666667 171.3535 20.463512080448734 923.3296666666666 664.6614999999999 670.7989642748911 219.207;222.026;273.717;248.198;344.076;316.771 141.536;142.777;163.744;183.659;187.725;178.963 484.566;497.741;831.582;299.409;2052.67;1374.01 0 Exp 2,2(0.14);Exp 5,1(0.07);Linear,8(0.54);Poly 2,4(0.27) 2.0611248795756554 32.66902565956116 1.5347857475280762 5.283818244934082 0.9295602702905502 1.929691195487976 186.29791218670533 282.8860078132946 117.5972193071106 196.104327359556 327.5723133946799 851.1370199386533 UP 0.6 0.4 0.0 GO:0007154 3 cell communication 162 169 9 9 7 8 6 6 53 163 2325 0.90767 0.19375 0.28161 3.55 78968;84487;362282;25247;24451;24408 srebf1;slc17a6;pck1;nsg1;hmox1;grin1 SREBF1_32750;SLC17A6_32912;PCK1_9439;NSG1_32675;HMOX1_8815;GRIN1_32381 227.20759999999999 222.163 61.2776 106.97134976917883 250.88602260955795 124.53110472012881 148.37339999999998 156.00900000000001 39.7754 70.2391520803035 147.8909209428277 71.55845446460742 372.9938333333334 397.9955 140.784 130.40344653331314 371.49570921850574 129.05341540667888 177.986;369.631;227.854;216.472;61.2776;310.025 117.256;163.45;148.568;166.237;39.7754;254.954 348.781;452.105;506.507;342.576;140.784;447.21 5 1 5 84487;362282;25247;24451;24408 SLC17A6_32912;PCK1_9439;NSG1_32675;HMOX1_8815;GRIN1_32381 237.05191999999997 227.854 116.51934310376116 154.59688 163.45 76.65791108145329 377.8364 447.21 145.1910644471622 369.631;227.854;216.472;61.2776;310.025 163.45;148.568;166.237;39.7754;254.954 452.105;506.507;342.576;140.784;447.21 1 78968 SREBF1_32750 177.986 177.986 117.256 117.256 348.781 348.781 177.986 117.256 348.781 0 Exp 2,4(0.67);Hill,1(0.17);Poly 2,1(0.17) 2.017176514752091 12.5667964220047 1.5889767408370972 3.437419891357422 0.6926015233611625 1.8926048278808594 141.61269348311674 312.8025065168832 92.17037302958624 204.57642697041376 268.64934446240443 477.3383222042622 UP 0.8333333333333334 0.16666666666666666 0.0 GO:0098814 8 spontaneous synaptic transmission 1 1 1 1 1 1 1 1 58 0 2488 1.0 0.023165 0.023165 100.0 25247 nsg1 NSG1_32675 216.472 216.472 216.472 216.472 166.237 166.237 166.237 166.237 342.576 342.576 342.576 342.576 0.0 216.472 0.0 216.472 216.472 166.237 342.576 1 0 1 25247 NSG1_32675 216.472 216.472 166.237 166.237 342.576 342.576 216.472 166.237 342.576 0 0 Exp 2,1(1) 3.437419891357422 3.437419891357422 3.437419891357422 3.437419891357422 0.0 3.437419891357422 216.472 216.472 166.237 166.237 342.576 342.576 UP 1.0 0.0 0.0 GO:0098887 8 neurotransmitter receptor transport, endosome to postsynaptic membrane 1 1 1 1 1 1 1 1 58 0 2488 1.0 0.023165 0.023165 100.0 25247 nsg1 NSG1_32675 216.472 216.472 216.472 216.472 166.237 166.237 166.237 166.237 342.576 342.576 342.576 342.576 0.0 216.472 0.0 216.472 216.472 166.237 342.576 1 0 1 25247 NSG1_32675 216.472 216.472 166.237 166.237 342.576 342.576 216.472 166.237 342.576 0 0 Exp 2,1(1) 3.437419891357422 3.437419891357422 3.437419891357422 3.437419891357422 0.0 3.437419891357422 216.472 216.472 166.237 166.237 342.576 342.576 UP 1.0 0.0 0.0 GO:0006807 3 nitrogen compound metabolic process 1028 1128 33 31 27 24 22 22 37 1106 1382 0.16802 0.89085 0.29148 1.95 29142;365377;360243;78968;29483;291773;303872;362282;25247;497009;316273;681410;24494;24451;24450;84488;316098;171142;25086;297594;64564;29650 vnn1;trim72;top2a;srebf1;slc1a3;taf4b;pigz;pck1;nsg1;naaa;mcm3;loc681410;il1b;hmox1;hmgcs2;fgf13;exosc7;ehhadh;cyp2e1;cdca3;bbox1;adam10 VNN1_10157;TRIM72_33144;TOP2A_10059;SREBF1_32750;SLC1A3_32817;RGD1562997_32695;PIGZ_32744;PCK1_9439;NSG1_32675;NAAA_32484;MCM3_9207;LOC681410_33126;IL1B_8892;HMOX1_8815;HMGCS2_8812;FGF13_32529;EXOSC7_8580;EHHADH_8534;CYP2E1_8421;CDCA3_8260;BBOX1_8133;ADAM10_7983 238.16015454545456 228.4735 61.2776 100.76001175780071 217.28460924755316 95.74127395030456 148.58813636363638 148.1935 39.7754 66.04678100879953 135.72901650872652 61.15649867830312 627.0037272727272 493.2575 140.784 525.6633668248495 556.2322637507915 499.1847652586113 233.741;82.0928;203.468;177.986;303.435;279.902;355.097;227.854;216.472;151.002;229.093;410.591;153.991;61.2776;269.456;209.76;111.985;250.691;357.376;183.234;454.248;316.771 147.819;49.3056;108.442;117.256;189.179;166.045;212.48;148.568;166.237;107.821;133.518;326.66;109.464;39.7754;162.134;130.074;54.886;157.555;191.769;111.531;259.457;178.963 556.851;193.467;572.253;348.781;992.735;888.462;459.59;506.507;342.576;250.969;614.889;495.344;258.668;140.784;795.183;483.266;373.527;636.947;2610.68;407.422;491.171;1374.01 15 7 15 29142;365377;29483;303872;362282;25247;497009;681410;24494;24451;24450;316098;171142;25086;64564 VNN1_10157;TRIM72_33144;SLC1A3_32817;PIGZ_32744;PCK1_9439;NSG1_32675;NAAA_32484;LOC681410_33126;IL1B_8892;HMOX1_8815;HMGCS2_8812;EXOSC7_8580;EHHADH_8534;CYP2E1_8421;BBOX1_8133 242.62062666666668 233.741 118.39810462850362 154.874 157.555 78.03348119123521 606.9999333333333 491.171 598.8650837378585 233.741;82.0928;303.435;355.097;227.854;216.472;151.002;410.591;153.991;61.2776;269.456;111.985;250.691;357.376;454.248 147.819;49.3056;189.179;212.48;148.568;166.237;107.821;326.66;109.464;39.7754;162.134;54.886;157.555;191.769;259.457 556.851;193.467;992.735;459.59;506.507;342.576;250.969;495.344;258.668;140.784;795.183;373.527;636.947;2610.68;491.171 7 360243;78968;291773;316273;84488;297594;29650 TOP2A_10059;SREBF1_32750;RGD1562997_32695;MCM3_9207;FGF13_32529;CDCA3_8260;ADAM10_7983 228.602 209.76 51.6602320326446 135.11842857142855 130.074 27.36747424015807 669.869 572.253 356.5916765125062 203.468;177.986;279.902;229.093;209.76;183.234;316.771 108.442;117.256;166.045;133.518;130.074;111.531;178.963 572.253;348.781;888.462;614.889;483.266;407.422;1374.01 0 Exp 2,9(0.41);Linear,7(0.32);Poly 2,5(0.23);Power,1(0.05) 1.9311205456875336 43.451565861701965 1.5889767408370972 3.437419891357422 0.4747440846565398 1.848579466342926 196.0552254393994 280.26508365150966 120.98894315648229 176.1873295707904 407.34298678956577 846.6644677558887 UP 0.6818181818181818 0.3181818181818182 0.0 GO:0007189 8 adenylate cyclase-activating G protein-coupled receptor signaling pathway 24 24 3 3 2 2 2 2 57 22 2466 0.98309 0.10522 0.10522 8.33 316137;245920 adgre1;cxcl10 EMR1_8558;CXCL10_8408 231.5705 231.5705 119.065 159.10680394156628 281.7385693961773 142.41244568723852 138.44755 138.44755 89.1701 69.68883810916202 160.421182678106 62.37670310989784 1115.4755 1115.4755 178.281 1325.3931724814715 1533.3860796046915 1186.3256536758538 0.5 231.5705 119.065;344.076 89.1701;187.725 178.281;2052.67 1 1 1 316137 EMR1_8558 119.065 119.065 89.1701 89.1701 178.281 178.281 119.065 89.1701 178.281 1 245920 CXCL10_8408 344.076 344.076 187.725 187.725 2052.67 2052.67 344.076 187.725 2052.67 0 Linear,2(1) 2.762396537369916 5.559319972991943 2.470346212387085 3.0889737606048584 0.4374357343735955 2.7796599864959717 11.059719999999999 452.08128 41.863748000000015 235.031352 -721.42572 2952.37672 CONFLICT 0.5 0.5 0.0 GO:0006629 4 lipid metabolic process 289 320 19 18 17 14 14 14 45 306 2182 0.99516 0.012115 0.015307 4.38 286989;78968;303872;362282;497009;24451;24450;25315;171142;29740;50549;25086;25279;24232 ugt2b7;srebf1;pigz;pck1;naaa;hmox1;hmgcs2;ephx1;ehhadh;eci1;cyp4a1;cyp2e1;cyp24a1;c3 UGT2B7_33032;SREBF1_32750;PIGZ_32744;PCK1_9439;NAAA_32484;HMOX1_8815;HMGCS2_8812;EPHX1_8567;EHHADH_8534;ECI1_8520;CYP4A1_33111;CYP2E1_8421;CYP24A1_32574;C3_8175 198.01290500000002 192.4345 4.13867 119.82497770849666 204.68991491981188 110.24675390901173 118.22719142857144 129.17849999999999 1.39768 69.02699515867761 124.13985835967492 62.529603883695906 764.2595857142858 376.124 16.5686 1122.9842287558256 720.8445247311826 1075.4497374858163 4.13867;177.986;355.097;227.854;151.002;61.2776;269.456;12.5094;250.691;195.758;375.605;357.376;189.111;144.319 1.39768;117.256;212.48;148.568;107.821;39.7754;162.134;3.282;157.555;130.778;197.092;191.769;127.579;57.6936 16.5686;348.781;459.59;506.507;250.969;140.784;795.183;61.3966;636.947;388.001;3966.72;2610.68;364.247;153.26 13 1 13 286989;303872;362282;497009;24451;24450;25315;171142;29740;50549;25086;25279;24232 UGT2B7_33032;PIGZ_32744;PCK1_9439;NAAA_32484;HMOX1_8815;HMGCS2_8812;EPHX1_8567;EHHADH_8534;ECI1_8520;CYP4A1_33111;CYP2E1_8421;CYP24A1_32574;C3_8175 199.55343615384615 195.758 124.57340529516321 118.30189846153847 130.778 71.84498533918259 796.2194769230769 388.001 1162.1931641247638 4.13867;355.097;227.854;151.002;61.2776;269.456;12.5094;250.691;195.758;375.605;357.376;189.111;144.319 1.39768;212.48;148.568;107.821;39.7754;162.134;3.282;157.555;130.778;197.092;191.769;127.579;57.6936 16.5686;459.59;506.507;250.969;140.784;795.183;61.3966;636.947;388.001;3966.72;2610.68;364.247;153.26 1 78968 SREBF1_32750 177.986 177.986 117.256 117.256 348.781 348.781 177.986 117.256 348.781 0 Exp 2,3(0.22);Exp 5,1(0.08);Hill,2(0.15);Linear,6(0.43);Poly 2,2(0.15) 1.9020334056657173 27.3237544298172 1.5261523723602295 3.570159435272217 0.5225517751757007 1.8271021842956543 135.24474318517727 260.78106681482274 82.0686401434529 154.38574271368998 176.00447284860354 1352.514698579968 UP 0.9285714285714286 0.07142857142857142 0.0 GO:0046907 4 intracellular transport 174 183 3 3 3 3 3 3 56 180 2308 0.37713 0.80891 0.79696 1.64 366669;25247;311024 syne2;nsg1;kif5c SYNE2_9977;NSG1_32675;KIF5C_8965 250.01533333333336 256.817 216.472 30.71265713567186 255.78935566310068 25.399091297100767 179.80866666666665 166.237 164.88 24.69133678708666 186.41874817456272 26.293179870110972 524.5753333333333 372.239 342.576 289.92279471668536 524.492414416709 283.9727117874202 276.757;216.472;256.817 164.88;166.237;208.309 858.911;342.576;372.239 2 1 2 25247;311024 NSG1_32675;KIF5C_8965 236.6445 236.6445 28.5282230869715 187.273 187.273 29.749396498080337 357.4075 357.4075 20.974908450335256 216.472;256.817 166.237;208.309 342.576;372.239 1 366669 SYNE2_9977 276.757 276.757 164.88 164.88 858.911 858.911 276.757 164.88 858.911 0 Exp 2,2(0.67);Linear,1(0.34) 2.4175085228080477 7.536596655845642 1.748702883720398 3.437419891357422 0.8558957388516666 2.3504738807678223 215.2606900383081 284.7699766283586 151.86778878294143 207.74954455039187 196.49680632851494 852.6538603381517 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0030258 5 lipid modification 64 70 4 4 4 4 4 4 55 66 2422 0.97848 0.076801 0.076801 5.71 171142;29740;50549;25086 ehhadh;eci1;cyp4a1;cyp2e1 EHHADH_8534;ECI1_8520;CYP4A1_33111;CYP2E1_8421 294.8575 304.0335 195.758 86.02347009392265 299.0858176920722 76.88811812793041 169.2985 174.662 130.778 31.086656971547665 171.85257924701563 26.61028205024056 1900.587 1623.8135 388.001 1698.8074345781513 1870.3475127640036 1661.586402085599 2.5 366.4905 250.691;195.758;375.605;357.376 157.555;130.778;197.092;191.769 636.947;388.001;3966.72;2610.68 4 0 4 171142;29740;50549;25086 EHHADH_8534;ECI1_8520;CYP4A1_33111;CYP2E1_8421 294.8575 304.0335 86.02347009392265 169.2985 174.662 31.086656971547665 1900.587 1623.8135 1698.8074345781513 250.691;195.758;375.605;357.376 157.555;130.778;197.092;191.769 636.947;388.001;3966.72;2610.68 0 0 Exp 2,1(0.25);Linear,3(0.75) 1.6274438291645494 6.523290038108826 1.5261523723602295 1.8089147806167603 0.12343868549076494 1.594111442565918 210.55449930795587 379.16050069204414 138.83357616788336 199.76342383211662 235.75571411341184 3565.418285886588 UP 1.0 0.0 0.0 GO:0007010 6 cytoskeleton organization 170 184 7 7 6 6 5 5 54 179 2309 0.74928 0.42456 0.61263 2.72 246118;313506;25595;24503;84488 tubb3;stil;map2;ina;fgf13 TUBB3_32820;STIL_33274;MAP2_32650;INA_32322;FGF13_32529 250.9496 282.273 145.437 71.56246407370281 269.35900929251915 50.83709917450462 179.88359999999997 177.242 104.718 63.91598794354985 197.63314337029516 56.423755041438156 563.8712 459.059 237.081 415.21275195699366 575.9363246134625 392.13590297979556 282.273;311.636;145.437;305.642;209.76 238.208;177.242;104.718;249.176;130.074 354.06;1285.89;237.081;459.059;483.266 3 2 3 246118;25595;24503 TUBB3_32820;MAP2_32650;INA_32322 244.4506666666667 282.273 86.54078333556564 197.36733333333333 238.208 80.42386760989137 350.06666666666666 354.06 111.04286629195644 282.273;145.437;305.642 238.208;104.718;249.176 354.06;237.081;459.059 2 313506;84488 STIL_33274;FGF13_32529 260.698 260.698 72.0372104401611 153.65800000000002 153.65800000000002 33.35281265500693 884.5780000000001 884.5780000000001 567.5408731430714 311.636;209.76 177.242;130.074 1285.89;483.266 0 Exp 2,3(0.6);Linear,2(0.4) 1.9059136907126533 9.67851448059082 1.6343638896942139 2.545419454574585 0.39490941998984846 1.7091286182403564 188.2223345519751 313.6768654480249 123.85876639479298 235.90843360520702 199.92117610776614 927.8212238922342 UP 0.6 0.4 0.0 GO:0010035 4 response to inorganic substance 271 293 14 14 12 12 10 10 49 283 2205 0.93083 0.13288 0.21099 3.41 79212;29483;24567;24494;24451;24450;24408;25086;24232;298566 slc6a1;slc1a3;mt1;il1b;hmox1;hmgcs2;grin1;cyp2e1;c3;c1qa SLC6A1_32594;SLC1A3_32817;MT1A_9255;IL1B_8892;HMOX1_8815;HMGCS2_8812;GRIN1_32381;CYP2E1_8421;C3_8175;C1QA_8167 240.65326 268.95550000000003 61.2776 108.0873750662881 228.628098498573 107.51943141221145 148.2839 161.94349999999997 39.7754 68.86657552593199 142.48044203995536 67.2643005618494 1303.3048 617.0735 140.784 2003.6559439610385 1202.2841127517888 1978.248268018002 145.445;303.435;392.753;153.991;61.2776;269.456;310.025;357.376;144.319;268.455 104.722;189.179;211.395;109.464;39.7754;162.134;254.954;191.769;57.6936;161.753 237.101;992.735;6610.49;258.668;140.784;795.183;447.21;2610.68;153.26;786.937 10 0 10 79212;29483;24567;24494;24451;24450;24408;25086;24232;298566 SLC6A1_32594;SLC1A3_32817;MT1A_9255;IL1B_8892;HMOX1_8815;HMGCS2_8812;GRIN1_32381;CYP2E1_8421;C3_8175;C1QA_8167 240.65326 268.95550000000003 108.0873750662881 148.2839 161.94349999999997 68.86657552593199 1303.3048 617.0735 2003.6559439610385 145.445;303.435;392.753;153.991;61.2776;269.456;310.025;357.376;144.319;268.455 104.722;189.179;211.395;109.464;39.7754;162.134;254.954;191.769;57.6936;161.753 237.101;992.735;6610.49;258.668;140.784;795.183;447.21;2610.68;153.26;786.937 0 0 Exp 2,3(0.3);Exp 5,1(0.1);Linear,5(0.5);Poly 2,1(0.1) 1.9186640636350787 19.431777119636536 1.5923793315887451 2.8712503910064697 0.3547589042704935 1.9105374813079834 173.66001086240075 307.6465091375993 105.59995426968119 190.9678457303188 61.42597967069082 2545.1836203293096 UP 1.0 0.0 0.0 GO:0030593 8 neutrophil chemotaxis 31 32 2 2 2 2 2 2 57 30 2458 0.96361 0.16853 0.16853 6.25 24494;245920 il1b;cxcl10 IL1B_8892;CXCL10_8408 249.0335 249.0335 153.991 134.41039250184494 263.03924586349535 132.94296437989627 148.59449999999998 148.59449999999998 109.464 55.33888380244048 154.36088702171665 54.734720442618105 1155.669 1155.669 258.668 1268.5509796622287 1287.8537388831437 1254.7015492198893 0.5 249.0335 153.991;344.076 109.464;187.725 258.668;2052.67 1 1 1 24494 IL1B_8892 153.991 153.991 109.464 109.464 258.668 258.668 153.991 109.464 258.668 1 245920 CXCL10_8408 344.076 344.076 187.725 187.725 2052.67 2052.67 344.076 187.725 2052.67 0 Linear,2(1) 2.6632653882476243 5.341596603393555 2.470346212387085 2.8712503910064697 0.28348206330778986 2.6707983016967773 62.75020000000001 435.3168 71.89872 225.29027999999997 -602.4529599999998 2913.7909599999994 CONFLICT 0.5 0.5 0.0 GO:1901575 4 organic substance catabolic process 296 332 11 11 11 8 8 8 51 324 2164 0.63976 0.51108 0.84549 2.41 365377;362282;497009;24451;316098;171142;29740;25279 trim72;pck1;naaa;hmox1;exosc7;ehhadh;eci1;cyp24a1 TRIM72_33144;PCK1_9439;NAAA_32484;HMOX1_8815;EXOSC7_8580;EHHADH_8534;ECI1_8520;CYP24A1_32574 158.721425 170.0565 61.2776 68.8103791510253 154.96701725569235 68.02062033526357 102.0335 117.69999999999999 39.7754 47.26762690032755 101.14381376712495 45.668911318602895 356.806125 368.887 140.784 163.33316590982065 336.1842729192159 169.72080892341975 82.0928;227.854;151.002;61.2776;111.985;250.691;195.758;189.111 49.3056;148.568;107.821;39.7754;54.886;157.555;130.778;127.579 193.467;506.507;250.969;140.784;373.527;636.947;388.001;364.247 8 0 8 365377;362282;497009;24451;316098;171142;29740;25279 TRIM72_33144;PCK1_9439;NAAA_32484;HMOX1_8815;EXOSC7_8580;EHHADH_8534;ECI1_8520;CYP24A1_32574 158.721425 170.0565 68.8103791510253 102.0335 117.69999999999999 47.26762690032755 356.806125 368.887 163.33316590982065 82.0928;227.854;151.002;61.2776;111.985;250.691;195.758;189.111 49.3056;148.568;107.821;39.7754;54.886;157.555;130.778;127.579 193.467;506.507;250.969;140.784;373.527;636.947;388.001;364.247 0 0 Exp 2,2(0.25);Linear,3(0.38);Poly 2,3(0.38) 1.829628253684645 14.785374164581299 1.5261523723602295 2.162810802459717 0.2805213147297969 1.79562246799469 111.03826500056674 206.40458499943327 69.27870567841904 134.78829432158096 243.62201557664844 469.9902344233516 UP 1.0 0.0 0.0 GO:0006811 5 ion transport 243 256 11 11 9 8 6 6 53 250 2238 0.61863 0.55275 1.0 2.34 79212;29483;84487;24408;84488;170924 slc6a1;slc1a3;slc17a6;grin1;fgf13;abcc4 SLC6A1_32594;SLC1A3_32817;SLC17A6_32912;GRIN1_32381;FGF13_32529;ABCC4_32768 263.82466666666664 274.0435 145.445 80.25304267045992 260.40296182735426 92.92132596077197 165.789 157.90249999999997 104.722 52.322408805405814 156.18341866591928 49.9454490182025 538.5948333333333 467.68550000000005 237.101 253.97804568538336 479.5106670964125 231.4854584430118 145.445;303.435;369.631;310.025;209.76;244.652 104.722;189.179;163.45;254.954;130.074;152.355 237.101;992.735;452.105;447.21;483.266;619.152 5 1 5 79212;29483;84487;24408;170924 SLC6A1_32594;SLC1A3_32817;SLC17A6_32912;GRIN1_32381;ABCC4_32768 274.63759999999996 303.435 84.69824152720061 172.93200000000002 163.45 55.130524317296185 549.6605999999999 452.105 282.3343331465376 145.445;303.435;369.631;310.025;244.652 104.722;189.179;163.45;254.954;152.355 237.101;992.735;452.105;447.21;619.152 1 84488 FGF13_32529 209.76 209.76 130.074 130.074 483.266 483.266 209.76 130.074 483.266 0 Exp 2,3(0.5);Hill,1(0.17);Linear,2(0.34) 1.7707158992511938 10.668710708618164 1.5415009260177612 2.0017645359039307 0.17709073086151816 1.772283911705017 199.60885841617872 328.0404749171546 123.9223534623938 207.65564653760623 335.37007151916856 741.8195951474984 UP 0.8333333333333334 0.16666666666666666 0.0 GO:0071310 5 cellular response to organic substance 516 551 20 20 17 12 11 11 48 540 1948 0.35233 0.76107 0.63495 2.0 78968;362282;25595;361680;24503;24494;24450;24408;304729;25315;245920 srebf1;pck1;map2;lsp1;ina;il1b;hmgcs2;grin1;gli2;ephx1;cxcl10 SREBF1_32750;PCK1_9439;MAP2_32650;LSP1_32853;INA_32322;IL1B_8892;HMGCS2_8812;GRIN1_32381;GLI2_8713;EPHX1_8567;CXCL10_8408 222.92985454545453 231.535 12.5094 95.3939148694126 251.21039099108884 83.15828895328629 149.3202727272727 148.568 3.282 69.97976878797319 167.78758229189302 61.67525766637795 598.0947818181819 459.059 61.3966 534.3850558900422 758.9962904640295 667.8830359823048 177.986;227.854;145.437;231.535;305.642;153.991;269.456;310.025;273.717;12.5094;344.076 117.256;148.568;104.718;141.502;249.176;109.464;162.134;254.954;163.744;3.282;187.725 348.781;506.507;237.081;580.905;459.059;258.668;795.183;447.21;831.582;61.3966;2052.67 7 4 7 362282;25595;24503;24494;24450;24408;25315 PCK1_9439;MAP2_32650;INA_32322;IL1B_8892;HMGCS2_8812;GRIN1_32381;EPHX1_8567 203.5592 227.854 107.25647831784637 147.47085714285714 148.568 87.72640050260159 395.0149428571429 447.21 236.017561434362 227.854;145.437;305.642;153.991;269.456;310.025;12.5094 148.568;104.718;249.176;109.464;162.134;254.954;3.282 506.507;237.081;459.059;258.668;795.183;447.21;61.3966 4 78968;361680;304729;245920 SREBF1_32750;LSP1_32853;GLI2_8713;CXCL10_8408 256.82849999999996 252.62599999999998 70.12666786370717 152.55675000000002 152.623 30.167923465992676 953.4845 706.2435 758.8479842605718 177.986;231.535;273.717;344.076 117.256;141.502;163.744;187.725 348.781;580.905;831.582;2052.67 0 Exp 2,5(0.46);Hill,1(0.1);Linear,5(0.46) 2.0432160238732457 22.784364581108093 1.5889767408370972 2.8712503910064697 0.36839501071568115 2.1014184951782227 166.55565337330046 279.3040557176086 107.96487213348726 190.6756733210582 282.2933946397885 913.896168996575 UP 0.6363636363636364 0.36363636363636365 0.0 GO:0009895 6 negative regulation of catabolic process 80 83 4 4 4 3 3 3 56 80 2408 0.8762 0.30166 0.44005 3.61 681410;24494;24451 loc681410;il1b;hmox1 LOC681410_33126;IL1B_8892;HMOX1_8815 208.61986666666667 153.991 61.2776 180.9508155821723 173.2531093370301 159.58776120806428 158.63313333333335 109.464 39.7754 149.62919562656663 129.1347237380739 131.59425005126528 298.26533333333333 258.668 140.784 180.56622055449162 264.033631248471 160.87428526942168 410.591;153.991;61.2776 326.66;109.464;39.7754 495.344;258.668;140.784 3 0 3 681410;24494;24451 LOC681410_33126;IL1B_8892;HMOX1_8815 208.61986666666667 153.991 180.9508155821723 158.63313333333335 109.464 149.62919562656663 298.26533333333333 258.668 180.56622055449162 410.591;153.991;61.2776 326.66;109.464;39.7754 495.344;258.668;140.784 0 0 Linear,1(0.34);Poly 2,2(0.67) 1.9934718243688372 6.196287155151367 1.5923793315887451 2.8712503910064697 0.701377579869298 1.7326574325561523 3.854742577225636 413.3849907561077 -10.68824115897246 327.95450782563915 93.93541948770272 502.595247178964 UP 1.0 0.0 0.0 GO:0009617 5 response to bacterium 110 127 8 8 7 7 7 7 52 120 2368 0.99207 0.025449 0.025449 5.51 294228;362282;25211;24450;25086;245920;24232 rt1-s3;pck1;lyz2;hmgcs2;cyp2e1;cxcl10;c3 RT1-S3_9763;PCK1_9439;LYZ2_32611;HMGCS2_8812;CYP2E1_8421;CXCL10_8408;C3_8175 253.85757142857142 227.854 144.319 75.83581853552046 253.4310560747664 78.55408630288636 146.9945142857143 148.568 57.6936 44.638333728438226 146.4848496526901 44.86841769893528 1009.5995714285715 506.507 153.26 936.0223098261522 1033.9506394922962 951.5195831733149 5.5 350.726 219.207;227.854;214.715;269.456;357.376;344.076;144.319 141.536;148.568;139.536;162.134;191.769;187.725;57.6936 484.566;506.507;464.331;795.183;2610.68;2052.67;153.26 5 2 5 362282;25211;24450;25086;24232 PCK1_9439;LYZ2_32611;HMGCS2_8812;CYP2E1_8421;C3_8175 242.744 227.854 78.34035348082112 139.94012 148.568 50.04471697863821 905.9921999999999 506.507 979.7318484915656 227.854;214.715;269.456;357.376;144.319 148.568;139.536;162.134;191.769;57.6936 506.507;464.331;795.183;2610.68;153.26 2 294228;245920 RT1-S3_9763;CXCL10_8408 281.6415 281.6415 88.29571665998316 164.63049999999998 164.63049999999998 32.66055511622566 1268.618 1268.618 1108.81697200575 219.207;344.076 141.536;187.725 484.566;2052.67 0 Exp 2,1(0.15);Exp 5,1(0.15);Linear,5(0.72) 1.8980731856170485 13.423287153244019 1.5622447729110718 2.470346212387085 0.30500968967490727 1.8089147806167603 197.67761086008878 310.0375319970541 113.9259738897031 180.06305468172545 316.18454047426167 1703.0146023828813 UP 0.7142857142857143 0.2857142857142857 0.0 GO:1902105 6 regulation of leukocyte differentiation 90 96 4 4 3 4 3 3 56 93 2395 0.81959 0.38538 0.48629 3.12 29142;24494;29650 vnn1;il1b;adam10 VNN1_10157;IL1B_8892;ADAM10_7983 234.83433333333335 233.741 153.991 81.39550745178343 198.0313264443401 70.36691917873252 145.41533333333334 147.819 109.464 34.811793408747775 129.52092942696103 31.075467377775148 729.843 556.851 258.668 577.4440390972965 488.13033889149835 445.5064771892209 233.741;153.991;316.771 147.819;109.464;178.963 556.851;258.668;1374.01 2 1 2 29142;24494 VNN1_10157;IL1B_8892 193.866 193.866 56.391765799627166 128.6415 128.6415 27.121080592409903 407.7595 407.7595 210.84722133454832 233.741;153.991 147.819;109.464 556.851;258.668 1 29650 ADAM10_7983 316.771 316.771 178.963 178.963 1374.01 1374.01 316.771 178.963 1374.01 0 Linear,3(1) 2.088214073591314 6.444428205490112 1.6434866189956665 2.8712503910064697 0.6423719921941349 1.929691195487976 142.72664578263115 326.9420208840355 106.0220806741256 184.80858599254105 76.40355602705301 1383.282443972947 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0051047 6 positive regulation of secretion 140 149 4 4 4 3 3 3 56 146 2342 0.54316 0.68151 1.0 2.01 79212;294228;24494 slc6a1;rt1-s3;il1b SLC6A1_32594;RT1-S3_9763;IL1B_8892 172.881 153.991 145.445 40.34640301191662 176.5171241525987 42.50235582512601 118.574 109.464 104.722 20.02652550993314 120.33434215073773 21.130709378279665 326.77833333333336 258.668 237.101 137.0729538834461 339.7880600824139 143.86930648626907 145.445;219.207;153.991 104.722;141.536;109.464 237.101;484.566;258.668 2 1 2 79212;24494 SLC6A1_32594;IL1B_8892 149.71800000000002 149.71800000000002 6.042934552019437 107.09299999999999 107.09299999999999 3.353100356387069 247.8845 247.8845 15.25017194985087 145.445;153.991 104.722;109.464 237.101;258.668 1 294228 RT1-S3_9763 219.207 219.207 141.536 141.536 484.566 484.566 219.207 141.536 484.566 0 Linear,3(1) 2.172952055843319 6.658130645751953 1.7851157188415527 2.8712503910064697 0.5748377870084617 2.0017645359039307 127.22474698606408 218.53725301393592 95.91185300757817 141.23614699242182 171.66568395981284 481.8909827068538 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0051130 6 positive regulation of cellular component organization 262 280 8 8 8 6 6 6 53 274 2214 0.52356 0.64412 1.0 2.14 78968;24494;24408;25311;502902;24232 srebf1;il1b;grin1;dcc;clec7a;c3 SREBF1_32750;IL1B_8892;GRIN1_32381;DCC_32537;CLEC7A_32927;C3_8175 241.25066666666666 213.09199999999998 144.319 105.15062633130951 252.1953776561285 109.87989823664512 176.94993333333332 150.45749999999998 57.6936 104.52156351579647 187.49458824177248 107.74696051882377 332.67883333333333 324.095 153.26 123.70037938731909 340.87246339725317 123.71725028426935 177.986;153.991;310.025;248.198;412.985;144.319 117.256;109.464;254.954;183.659;338.673;57.6936 348.781;258.668;447.21;299.409;488.745;153.26 4 2 4 24494;24408;502902;24232 IL1B_8892;GRIN1_32381;CLEC7A_32927;C3_8175 255.33 232.00799999999998 129.66582316606534 190.19615 182.209 129.5036163235993 336.97074999999995 352.93899999999996 158.1866782494132 153.991;310.025;412.985;144.319 109.464;254.954;338.673;57.6936 258.668;447.21;488.745;153.26 2 78968;25311 SREBF1_32750;DCC_32537 213.09199999999998 213.09199999999998 49.64738132066996 150.45749999999998 150.45749999999998 46.95401159113043 324.095 324.095 34.91127600074178 177.986;248.198 117.256;183.659 348.781;299.409 0 Exp 2,2(0.34);Exp 5,1(0.17);Linear,1(0.17);Poly 2,2(0.34) 1.9856348757017515 12.13666033744812 1.5889767408370972 2.8712503910064697 0.4519620017909015 1.9254007935523987 157.11264232238204 325.3886910109513 93.31526407434274 260.5846025923239 233.69791524070894 431.6597514259577 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0062237 7 protein localization to postsynapse 7 7 3 3 3 3 3 3 56 4 2484 0.99999 3.8705E-4 3.8705E-4 42.86 25247;311024;24408 nsg1;kif5c;grin1 NSG1_32675;KIF5C_8965;GRIN1_32381 261.1046666666667 256.817 216.472 46.923650927153396 268.4311935143043 41.604681074689914 209.83333333333334 208.309 166.237 44.37813894625732 217.29911833550068 38.76782979924749 387.3416666666667 372.239 342.576 53.92713968247619 393.435443676853 50.37132098363636 0.0 216.472 0.0 216.472 216.472;256.817;310.025 166.237;208.309;254.954 342.576;372.239;447.21 3 0 3 25247;311024;24408 NSG1_32675;KIF5C_8965;GRIN1_32381 261.1046666666667 256.817 46.923650927153396 209.83333333333334 208.309 44.37813894625732 387.3416666666667 372.239 53.92713968247619 216.472;256.817;310.025 166.237;208.309;254.954 342.576;372.239;447.21 0 0 Exp 2,3(1) 2.4926630395140164 7.7048081159591675 1.9169143438339233 3.437419891357422 0.7833009874938153 2.3504738807678223 208.0055569781288 314.2037763552046 159.61474161849088 260.0519250481758 326.31736338655014 448.36596994678325 UP 1.0 0.0 0.0 GO:0033044 7 regulation of chromosome organization 75 76 2 2 2 2 2 2 57 74 2414 0.74304 0.53143 0.69537 2.63 360243;78968 top2a;srebf1 TOP2A_10059;SREBF1_32750 190.72699999999998 190.72699999999998 177.986 18.018494998195845 187.80884423337852 17.53952382031759 112.84899999999999 112.84899999999999 108.442 6.2324391693785035 113.85836445047488 6.066767245596412 460.51700000000005 460.51700000000005 348.781 158.0185666053199 434.9253625508819 153.81808598908592 203.468;177.986 108.442;117.256 572.253;348.781 0 2 0 2 360243;78968 TOP2A_10059;SREBF1_32750 190.72699999999998 190.72699999999998 18.018494998195845 112.84899999999999 112.84899999999999 6.2324391693785035 460.51700000000005 460.51700000000005 158.0185666053199 203.468;177.986 108.442;117.256 572.253;348.781 0 Exp 2,2(1) 1.8183136340678756 3.6697274446487427 1.5889767408370972 2.0807507038116455 0.3477367040302853 1.8348637223243713 165.75464 215.69935999999996 104.21127999999999 121.48671999999999 241.51444000000004 679.5195600000001 DOWN 0.0 1.0 0.0 GO:0033554 4 cellular response to stress 394 417 13 13 11 9 7 7 52 410 2078 0.22583 0.87265 0.47509 1.68 360243;78968;362282;338475;316273;24451;245920 top2a;srebf1;pck1;nrep;mcm3;hmox1;cxcl10 TOP2A_10059;SREBF1_32750;PCK1_9439;NREP_9364;MCM3_9207;HMOX1_8815;CXCL10_8408 209.39722857142857 222.026 61.2776 83.65372931016914 218.17702454948397 93.25326523651121 125.43734285714285 133.518 39.7754 45.59693843110002 127.30998648290144 48.78916198752394 676.2321428571429 506.507 140.784 627.6610676079962 800.0496346695136 729.958977472096 203.468;177.986;227.854;222.026;229.093;61.2776;344.076 108.442;117.256;148.568;142.777;133.518;39.7754;187.725 572.253;348.781;506.507;497.741;614.889;140.784;2052.67 2 5 2 362282;24451 PCK1_9439;HMOX1_8815 144.5658 144.5658 117.78730202564284 94.1717 94.1717 76.92798520291561 323.64549999999997 323.64549999999997 258.60521333588775 227.854;61.2776 148.568;39.7754 506.507;140.784 5 360243;78968;338475;316273;245920 TOP2A_10059;SREBF1_32750;NREP_9364;MCM3_9207;CXCL10_8408 235.32979999999998 222.026 63.923998781365434 137.9436 133.518 30.90087649727753 817.2668000000001 572.253 697.9944993266064 203.468;177.986;222.026;229.093;344.076 108.442;117.256;142.777;133.518;187.725 572.253;348.781;497.741;614.889;2052.67 0 Exp 2,4(0.58);Linear,2(0.29);Poly 2,1(0.15) 1.8699552995016295 13.28191888332367 1.5347857475280762 2.470346212387085 0.35450726051279363 1.8518693447113037 147.42567865203836 271.36877849081884 91.65865815945087 159.21602755483485 211.25431694928704 1141.2099687649988 DOWN 0.2857142857142857 0.7142857142857143 0.0 GO:0033993 5 response to lipid 414 443 18 18 15 14 12 12 47 431 2057 0.78593 0.32303 0.49203 2.71 78968;79212;362282;58827;25595;681410;24494;24450;25315;25279;245920;24232 srebf1;slc6a1;pck1;mest;map2;loc681410;il1b;hmgcs2;ephx1;cyp24a1;cxcl10;c3 SREBF1_32750;SLC6A1_32594;PCK1_9439;MEST_9219;MAP2_32650;LOC681410_33126;IL1B_8892;HMGCS2_8812;EPHX1_8567;CYP24A1_32574;CXCL10_8408;C3_8175 207.75028333333333 183.5485 12.5094 105.36905187931207 208.90225932077036 90.67468762408376 137.38696666666667 122.41749999999999 3.282 80.12656541460268 135.47555272727277 64.55646600428571 504.46055 356.514 61.3966 526.5666923735932 566.2411617187825 636.2627521707158 177.986;145.445;227.854;272.228;145.437;410.591;153.991;269.456;12.5094;189.111;344.076;144.319 117.256;104.722;148.568;198.842;104.718;326.66;109.464;162.134;3.282;127.579;187.725;57.6936 348.781;237.101;506.507;543.288;237.081;495.344;258.668;795.183;61.3966;364.247;2052.67;153.26 10 2 10 79212;362282;58827;25595;681410;24494;24450;25315;25279;24232 SLC6A1_32594;PCK1_9439;MEST_9219;MAP2_32650;LOC681410_33126;IL1B_8892;HMGCS2_8812;EPHX1_8567;CYP24A1_32574;C3_8175 197.09414 171.551 106.20884067563615 134.36626 118.5215 86.66186604017301 365.20756 311.4575 219.82182711687813 145.445;227.854;272.228;145.437;410.591;153.991;269.456;12.5094;189.111;144.319 104.722;148.568;198.842;104.718;326.66;109.464;162.134;3.282;127.579;57.6936 237.101;506.507;543.288;237.081;495.344;258.668;795.183;61.3966;364.247;153.26 2 78968;245920 SREBF1_32750;CXCL10_8408 261.031 261.031 117.44336528727376 152.4905 152.4905 49.829107763434735 1200.7255 1200.7255 1204.831466289165 177.986;344.076 117.256;187.725 348.781;2052.67 0 Exp 2,3(0.25);Exp 5,1(0.09);Hill,1(0.09);Linear,6(0.5);Poly 2,1(0.09) 2.0601056663645063 25.024203419685364 1.5889767408370972 2.8712503910064697 0.34721301613047556 2.1135289669036865 148.13212987589242 267.3684367907743 92.05109443753285 182.72283889580046 206.5273968435788 802.3937031564213 UP 0.8333333333333334 0.16666666666666666 0.0 GO:0048513 4 animal organ development 418 452 20 20 18 13 12 12 47 440 2048 0.76357 0.34991 0.60477 2.65 246118;365377;360243;313506;78968;84487;24451;24450;304729;25315;50549;29182 tubb3;trim72;top2a;stil;srebf1;slc17a6;hmox1;hmgcs2;gli2;ephx1;cyp4a1;cdh22 TUBB3_32820;TRIM72_33144;TOP2A_10059;STIL_33274;SREBF1_32750;SLC17A6_32912;HMOX1_8815;HMGCS2_8812;GLI2_8713;EPHX1_8567;CYP4A1_33111;CDH22_32502 227.22615 271.5865 12.5094 120.77931059133132 242.71610021134947 116.02927310486844 136.38516666666666 162.79199999999997 3.282 73.91335626946571 146.61349947162634 71.42829414312007 813.3313833333333 512.1790000000001 61.3966 1052.6253283701744 736.8263587551517 979.8987979098827 282.273;82.0928;203.468;311.636;177.986;369.631;61.2776;269.456;273.717;12.5094;375.605;307.062 238.208;49.3056;108.442;177.242;117.256;163.45;39.7754;162.134;163.744;3.282;197.092;216.691 354.06;193.467;572.253;1285.89;348.781;452.105;140.784;795.183;831.582;61.3966;3966.72;757.755 8 4 8 246118;365377;84487;24451;24450;25315;50549;29182 TUBB3_32820;TRIM72_33144;SLC17A6_32912;HMOX1_8815;HMGCS2_8812;EPHX1_8567;CYP4A1_33111;CDH22_32502 219.98835 275.8645 145.29256719322274 133.74225 162.79199999999997 89.82094437985256 840.183825 403.0825 1292.0018739174002 282.273;82.0928;369.631;61.2776;269.456;12.5094;375.605;307.062 238.208;49.3056;163.45;39.7754;162.134;3.282;197.092;216.691 354.06;193.467;452.105;140.784;795.183;61.3966;3966.72;757.755 4 360243;313506;78968;304729 TOP2A_10059;STIL_33274;SREBF1_32750;GLI2_8713 241.70175 238.59249999999997 61.744883709097685 141.671 140.5 33.925270993759256 759.6265000000001 701.9175 402.50619820693447 203.468;311.636;177.986;273.717 108.442;177.242;117.256;163.744 572.253;1285.89;348.781;831.582 0 Exp 2,4(0.34);Hill,2(0.17);Linear,4(0.34);Poly 2,2(0.17) 1.8510758618791423 22.468482732772827 1.5810112953186035 2.545419454574585 0.3056475066310187 1.7858976125717163 158.88882186720627 295.5634781327937 94.56474845055963 178.20558488277373 217.7525369768017 1408.910229689865 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0016070 6 RNA metabolic process 159 180 6 6 5 5 4 4 55 176 2312 0.59436 0.60947 1.0 2.22 78968;291773;681410;316098 srebf1;taf4b;loc681410;exosc7 SREBF1_32750;RGD1562997_32695;LOC681410_33126;EXOSC7_8580 245.116 228.944 111.985 130.15675354740526 235.53794634274226 125.15211934912558 166.21175 141.6505 54.886 116.23791235328518 161.02228576422266 111.44781750706137 526.5285 434.4355 348.781 249.64772795614755 480.88287800402 225.34573065614023 177.986;279.902;410.591;111.985 117.256;166.045;326.66;54.886 348.781;888.462;495.344;373.527 2 2 2 681410;316098 LOC681410_33126;EXOSC7_8580 261.288 261.288 211.1463275029902 190.77300000000002 190.77300000000002 192.17323835019275 434.4355 434.4355 86.13762676380146 410.591;111.985 326.66;54.886 495.344;373.527 2 78968;291773 SREBF1_32750;RGD1562997_32695 228.944 228.944 72.06549471140809 141.6505 141.6505 34.499032747310494 618.6215 618.6215 381.61209477753727 177.986;279.902 117.256;166.045 348.781;888.462 0 Exp 2,1(0.25);Linear,1(0.25);Poly 2,2(0.5) 1.7165883614022692 6.884992361068726 1.5889767408370972 1.9251312017440796 0.14842137074576664 1.6854422092437744 117.56238152354281 372.6696184764572 52.29859589378053 280.12490410621945 281.87372660297535 771.1832733970247 CONFLICT 0.5 0.5 0.0 GO:0032102 6 negative regulation of response to external stimulus 106 114 5 5 5 3 3 3 56 111 2377 0.73004 0.49718 0.74619 2.63 294228;24408;80841 rt1-s3;grin1;fabp7 RT1-S3_9763;GRIN1_32381;FABP7_8592 252.41 227.998 219.207 50.08928616979887 244.5713842849472 47.5974282930761 197.13666666666668 194.92 141.536 56.74148296734329 182.02429210667623 58.568141854352156 402.0653333333333 447.21 274.42 112.1109540827005 431.2151866833721 100.19172903897984 219.207;310.025;227.998 141.536;254.954;194.92 484.566;447.21;274.42 2 1 2 24408;80841 GRIN1_32381;FABP7_8592 269.01149999999996 269.01149999999996 58.00184794038909 224.937 224.937 42.45044850175302 360.815 360.815 122.18098072122359 310.025;227.998 254.954;194.92 447.21;274.42 1 294228 RT1-S3_9763 219.207 219.207 141.536 141.536 484.566 484.566 219.207 141.536 484.566 0 Exp 2,2(0.67);Linear,1(0.34) 2.624655555193785 8.985848307609558 1.7851157188415527 5.283818244934082 1.983025135278572 1.9169143438339233 195.72863680684688 309.09136319315314 132.92763415445455 261.34569917887876 275.1998458765779 528.9308207900888 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0097267 7 omega-hydroxylase P450 pathway 2 2 1 1 1 1 1 1 58 1 2487 0.99947 0.045801 0.045801 50.0 50549 cyp4a1 CYP4A1_33111 375.605 375.605 375.605 375.6050000000001 197.092 197.092 197.092 197.092 3966.72 3966.72 3966.72 3966.72 0.0 375.605 0.0 375.605 375.605 197.092 3966.72 1 0 1 50549 CYP4A1_33111 375.605 375.605 197.092 197.092 3966.72 3966.72 375.605 197.092 3966.72 0 0 Linear,1(1) 1.5810112953186035 1.5810112953186035 1.5810112953186035 1.5810112953186035 0.0 1.5810112953186035 375.605 375.605 197.092 197.092 3966.72 3966.72 UP 1.0 0.0 0.0 GO:0045665 8 negative regulation of neuron differentiation 51 54 4 4 4 3 3 3 56 51 2437 0.96527 0.12787 0.12787 5.56 25595;24494;84488 map2;il1b;fgf13 MAP2_32650;IL1B_8892;FGF13_32529 169.72933333333333 153.991 145.437 34.93040844784579 181.40707546226884 35.14168611911384 114.75200000000001 109.464 104.718 13.479758603179857 119.46349375312343 13.199604945736903 326.33833333333337 258.668 237.081 136.33128425395734 370.1550670498084 139.9341581489872 1.5 181.8755 145.437;153.991;209.76 104.718;109.464;130.074 237.081;258.668;483.266 2 1 2 25595;24494 MAP2_32650;IL1B_8892 149.714 149.714 6.048591406270443 107.09100000000001 107.09100000000001 3.3559287835111813 247.8745 247.8745 15.264314085473336 145.437;153.991 104.718;109.464 237.081;258.668 1 84488 FGF13_32529 209.76 209.76 130.074 130.074 483.266 483.266 209.76 130.074 483.266 0 Exp 2,1(0.34);Linear,2(0.67) 2.165549511052735 6.660852909088135 1.6639630794525146 2.8712503910064697 0.6091829781993233 2.1256394386291504 130.20185512160938 209.25681154505727 99.49821717401221 130.0057828259878 172.06496215387352 480.6117045127932 UP 0.6666666666666666 0.3333333333333333 0.0