Gene Ontology Analyses GO Category: BP GO File Creation Date: 07/15/20 Deduplicate Gene Sets: true Data Source: Kidney_2,3-Benzofluorene_Female Work Source: Kidney_2,3-Benzofluorene_Female_williams_0.05_NOMTC_foldfilter1.5_BMD BMDExpress2 Version: BMDExpress 2.30.0507 BETA Timestamp (Start Time): 02/12/2021 22:59.23 Remove Promiscuous Probes: true Remove BMD > Highest Dose from Category Descriptive Statistics: true Remove BMD with p-Value < Cutoff: 0.1 Remove genes with BMDU/BMDL >: 40.0 Identify conflicting probe sets: 0.5 Category Count: 3551 Total Run Time: 1 seconds GO/Pathway/Gene Set/Gene ID GO Level GO/Pathway/Gene Set/Gene Name All Genes (Expression Data) All Genes (Platform) Input Genes Genes with BMD <= Highest Dose Genes with BMD p-Value >= Genes with BMDU/BMDL <= Genes That Passed All Filters Fisher's A Parameter Fisher's B Parameter Fisher's C Parameter Fisher's D Parameter Fisher's Exact Left P-Value Fisher's Exact Right P-Value Fisher's Exact Two Tail Percentage Entrez Gene IDs Gene Symbols Probe IDs Genes with Conflicting Probesets BMD Mean BMD Median BMD Minimum BMD Standard Deviation BMD wMean BMD wSD BMDL Mean BMDL Median BMDL Minimum BMDL Standard Deviation BMDL wMean BMDL wSD BMDU Mean BMDU Median BMDU Minimum BMDU Standard Deviation BMDU wMean BMDU wSD 5th Percentile Index BMD at 5th Percentile of Total Genes 10th Percentile Index BMD at 10th Percentile of Total Genes BMD List BMDL List BMDU List Probes with Adverse Direction Up Probes with Adverse Direction Down Genes with Adverse Direction Up Genes Up List Genes Up Probes List Genes Up BMD Mean Genes Up BMD Median Genes Up SD Genes Up BMDL Mean Genes Up BMDL Median Genes Up BMDL SD Genes Up BMDU Mean Genes Up BMDU Median Genes Up BMDU SD BMD list (up) BMDL List (up) BMDU List (up) Genes with Adverse Direction Down Genes Down List Genes Down Probes List Genes Down BMD Mean Genes Down BMD Median Genes Down SD Genes Down BMDL Mean Genes Down BMDL Median Genes Down BMDL SD Genes Down BMDU Mean Genes Down BMDU Median Genes Down BMDU SD BMD list (down) BMDL List (down) BMDU List (down) Genes with Adverse Conflict Count Genes Conflict List Genes Conflict Probes List BMD list (Conflict) BMDL list (Conflict) BMDU list (Conflict) Model Counts Mean Fold Change Total Fold Change Min Fold Change Max Fold Change Standard Deviation Fold Change Median Fold Change Lower bound of the 95% confidence interval - BMD Upper bound of the 95% confidence interval - BMD Lower bound of the 95% confidence interval - BMDL Upper bound of the 95% confidence interval - BMDL Lower bound of the 95% confidence interval - BMDU Upper bound of the 95% confidence interval - BMDU Overall Direction Percent Genes With Overall Direction Up Percent Genes With Overall Direction Down Percent Genes With Overall Direction Conflict GO:0000018 7 regulation of DNA recombination 13 13 1 1 1 0 0 0 68 13 2466 0.70283 1.0 1.0 0.0 0 0 0 0 0 GO:0000041 8 transition metal ion transport 18 19 1 1 0 1 0 0 68 19 2460 0.5969 1.0 1.0 0.0 0 0 0 0 0 GO:0000070 6 mitotic sister chromatid segregation 13 13 1 1 1 0 0 0 68 13 2466 0.70283 1.0 1.0 0.0 0 0 0 0 0 GO:0000077 8 DNA damage checkpoint 17 18 1 1 1 0 0 0 68 18 2461 0.61339 1.0 1.0 0.0 0 0 0 0 0 GO:0000082 6 G1/S transition of mitotic cell cycle 23 25 1 1 0 0 0 0 68 25 2454 0.50673 1.0 1.0 0.0 0 0 0 0 0 GO:0000132 8 establishment of mitotic spindle orientation 8 8 1 1 1 0 0 0 68 8 2471 0.8051 1.0 1.0 0.0 0 0 0 0 0 GO:0000187 10 activation of MAPK activity 35 38 2 2 1 0 0 0 68 38 2441 0.35488 1.0 0.62448 0.0 0 0 0 0 0 GO:0000188 10 inactivation of MAPK activity 6 8 2 2 1 0 0 0 68 8 2471 0.8051 1.0 1.0 0.0 0 0 0 0 0 GO:0000278 4 mitotic cell cycle 41 47 3 3 2 1 0 0 68 47 2432 0.27702 1.0 0.6361 0.0 0 0 0 0 0 GO:0000290 9 deadenylation-dependent decapping of nuclear-transcribed mRNA 3 3 1 1 1 0 0 0 68 3 2476 0.922 1.0 1.0 0.0 0 0 0 0 0 GO:0000723 6 telomere maintenance 14 16 1 1 0 0 0 0 68 16 2463 0.64774 1.0 1.0 0.0 0 0 0 0 0 GO:0000956 8 nuclear-transcribed mRNA catabolic process 15 16 1 1 1 0 0 0 68 16 2463 0.64774 1.0 1.0 0.0 0 0 0 0 0 GO:0000959 7 mitochondrial RNA metabolic process 9 9 1 1 0 1 0 0 68 9 2470 0.78354 1.0 1.0 0.0 0 0 0 0 0 GO:0000963 8 mitochondrial RNA processing 4 4 1 1 0 1 0 0 68 4 2475 0.89735 1.0 1.0 0.0 0 0 0 0 0 GO:0001508 5 action potential 12 12 1 1 0 0 0 0 68 12 2467 0.72221 1.0 1.0 0.0 0 0 0 0 0 GO:0001516 8 prostaglandin biosynthetic process 5 7 1 1 1 0 0 0 68 7 2472 0.82725 1.0 1.0 0.0 0 0 0 0 0 GO:0001541 5 ovarian follicle development 20 20 1 1 0 1 0 0 68 20 2459 0.58084 1.0 1.0 0.0 0 0 0 0 0 GO:0001578 6 microtubule bundle formation 6 7 2 2 2 0 0 0 68 7 2472 0.82725 1.0 1.0 0.0 0 0 0 0 0 GO:0001649 5 osteoblast differentiation 27 27 2 1 0 0 0 0 68 27 2452 0.47977 1.0 1.0 0.0 0 0 0 0 0 GO:0001655 5 urogenital system development 6 8 1 1 0 1 0 0 68 8 2471 0.8051 1.0 1.0 0.0 0 0 0 0 0 GO:0001662 5 behavioral fear response 10 11 1 1 0 0 0 0 68 11 2468 0.74211 1.0 1.0 0.0 0 0 0 0 0 GO:0001702 6 gastrulation with mouth forming second 6 7 1 1 0 0 0 0 68 7 2472 0.82725 1.0 1.0 0.0 0 0 0 0 0 GO:0001704 4 formation of primary germ layer 12 12 1 1 1 0 0 0 68 12 2467 0.72221 1.0 1.0 0.0 0 0 0 0 0 GO:0001706 5 endoderm formation 3 3 1 1 1 0 0 0 68 3 2476 0.922 1.0 1.0 0.0 0 0 0 0 0 GO:0001755 6 neural crest cell migration 7 7 1 1 0 0 0 0 68 7 2472 0.82725 1.0 1.0 0.0 0 0 0 0 0 GO:0001765 7 membrane raft assembly 3 3 1 1 0 1 0 0 68 3 2476 0.922 1.0 1.0 0.0 0 0 0 0 0 GO:0001779 6 natural killer cell differentiation 3 3 1 1 1 0 0 0 68 3 2476 0.922 1.0 1.0 0.0 0 0 0 0 0 GO:0001788 9 antibody-dependent cellular cytotoxicity 1 2 1 1 0 0 0 0 68 2 2477 0.94731 1.0 1.0 0.0 0 0 0 0 0 GO:0001794 8 type IIa hypersensitivity 1 2 1 1 0 0 0 0 68 2 2477 0.94731 1.0 1.0 0.0 0 0 0 0 0 GO:0001803 8 regulation of type III hypersensitivity 3 4 1 1 0 0 0 0 68 4 2475 0.89735 1.0 1.0 0.0 0 0 0 0 0 GO:0001805 9 positive regulation of type III hypersensitivity 3 4 1 1 0 0 0 0 68 4 2475 0.89735 1.0 1.0 0.0 0 0 0 0 0 GO:0001816 5 cytokine production 29 29 1 1 1 0 0 0 68 29 2450 0.45422 1.0 1.0 0.0 0 0 0 0 0 GO:0001835 5 blastocyst hatching 6 6 1 1 1 0 0 0 68 6 2473 0.84999 1.0 1.0 0.0 0 0 0 0 0 GO:0001836 8 release of cytochrome c from mitochondria 13 13 1 1 0 0 0 0 68 13 2466 0.70283 1.0 1.0 0.0 0 0 0 0 0 GO:0001838 6 embryonic epithelial tube formation 11 11 1 1 0 0 0 0 68 11 2468 0.74211 1.0 1.0 0.0 0 0 0 0 0 GO:0001841 7 neural tube formation 4 4 1 1 0 0 0 0 68 4 2475 0.89735 1.0 1.0 0.0 0 0 0 0 0 GO:0001881 6 receptor recycling 3 3 1 1 1 0 0 0 68 3 2476 0.922 1.0 1.0 0.0 0 0 0 0 0 GO:0001895 7 retina homeostasis 2 2 1 1 1 0 0 0 68 2 2477 0.94731 1.0 1.0 0.0 0 0 0 0 0 GO:0001909 4 leukocyte mediated cytotoxicity 9 12 1 1 0 0 0 0 68 12 2467 0.72221 1.0 1.0 0.0 0 0 0 0 0 GO:0001911 7 negative regulation of leukocyte mediated cytotoxicity 7 8 1 1 1 0 0 0 68 8 2471 0.8051 1.0 1.0 0.0 0 0 0 0 0 GO:0001914 7 regulation of T cell mediated cytotoxicity 12 19 1 1 1 0 0 0 68 19 2460 0.5969 1.0 1.0 0.0 0 0 0 0 0 GO:0001915 8 negative regulation of T cell mediated cytotoxicity 3 3 1 1 1 0 0 0 68 3 2476 0.922 1.0 1.0 0.0 0 0 0 0 0 GO:0001916 8 positive regulation of T cell mediated cytotoxicity 9 16 1 1 1 0 0 0 68 16 2463 0.64774 1.0 1.0 0.0 0 0 0 0 0 GO:0001919 5 regulation of receptor recycling 8 8 2 2 1 1 0 0 68 8 2471 0.8051 1.0 1.0 0.0 0 0 0 0 0 GO:0001921 6 positive regulation of receptor recycling 7 7 2 2 1 1 0 0 68 7 2472 0.82725 1.0 1.0 0.0 0 0 0 0 0 GO:0001935 5 endothelial cell proliferation 7 8 1 1 1 0 0 0 68 8 2471 0.8051 1.0 1.0 0.0 0 0 0 0 0 GO:0001937 8 negative regulation of endothelial cell proliferation 16 17 1 1 0 1 0 0 68 17 2462 0.63033 1.0 1.0 0.0 0 0 0 0 0 GO:0001942 4 hair follicle development 7 8 1 1 0 1 0 0 68 8 2471 0.8051 1.0 1.0 0.0 0 0 0 0 0 GO:0001955 5 blood vessel maturation 3 3 1 1 0 1 0 0 68 3 2476 0.922 1.0 1.0 0.0 0 0 0 0 0 GO:0001957 5 intramembranous ossification 3 3 2 2 0 1 0 0 68 3 2476 0.922 1.0 1.0 0.0 0 0 0 0 0 GO:0001958 5 endochondral ossification 7 7 1 0 0 0 0 0 68 7 2472 0.82725 1.0 1.0 0.0 0 0 0 0 0 GO:0001974 4 blood vessel remodeling 15 17 1 1 0 0 0 0 68 17 2462 0.63033 1.0 1.0 0.0 0 0 0 0 0 GO:0001975 5 response to amphetamine 19 21 1 0 0 0 0 0 68 21 2458 0.56521 1.0 1.0 0.0 0 0 0 0 0 GO:0001976 5 nervous system process involved in regulation of systemic arterial blood pressure 2 3 1 1 0 1 0 0 68 3 2476 0.922 1.0 1.0 0.0 0 0 0 0 0 GO:0001990 6 regulation of systemic arterial blood pressure by hormone 7 10 1 1 0 1 0 0 68 10 2469 0.76254 1.0 1.0 0.0 0 0 0 0 0 GO:0001991 8 regulation of systemic arterial blood pressure by circulatory renin-angiotensin 1 1 1 1 0 1 0 0 68 1 2478 0.9733 1.0 1.0 0.0 0 0 0 0 0 GO:0002001 6 renin secretion into blood stream 1 1 1 1 0 1 0 0 68 1 2478 0.9733 1.0 1.0 0.0 0 0 0 0 0 GO:0002016 8 regulation of blood volume by renin-angiotensin 2 3 1 1 0 1 0 0 68 3 2476 0.922 1.0 1.0 0.0 0 0 0 0 0 GO:0002018 9 renin-angiotensin regulation of aldosterone production 1 1 1 1 0 1 0 0 68 1 2478 0.9733 1.0 1.0 0.0 0 0 0 0 0 GO:0002019 9 regulation of renal output by angiotensin 2 2 1 1 0 1 0 0 68 2 2477 0.94731 1.0 1.0 0.0 0 0 0 0 0 GO:0002035 9 brain renin-angiotensin system 1 2 1 1 0 1 0 0 68 2 2477 0.94731 1.0 1.0 0.0 0 0 0 0 0 GO:0002053 7 positive regulation of mesenchymal cell proliferation 10 10 1 1 0 1 0 0 68 10 2469 0.76254 1.0 1.0 0.0 0 0 0 0 0 GO:0002065 6 columnar/cuboidal epithelial cell differentiation 9 12 1 1 0 0 0 0 68 12 2467 0.72221 1.0 1.0 0.0 0 0 0 0 0 GO:0002066 6 columnar/cuboidal epithelial cell development 9 9 1 0 0 0 0 0 68 9 2470 0.78354 1.0 1.0 0.0 0 0 0 0 0 GO:0002068 7 glandular epithelial cell development 5 5 1 0 0 0 0 0 68 5 2474 0.87336 1.0 1.0 0.0 0 0 0 0 0 GO:0002209 4 behavioral defense response 11 12 1 1 0 0 0 0 68 12 2467 0.72221 1.0 1.0 0.0 0 0 0 0 0 GO:0002221 5 pattern recognition receptor signaling pathway 26 28 1 1 0 1 0 0 68 28 2451 0.46682 1.0 1.0 0.0 0 0 0 0 0 GO:0002224 6 toll-like receptor signaling pathway 21 23 1 1 0 1 0 0 68 23 2456 0.53518 1.0 1.0 0.0 0 0 0 0 0 GO:0002246 6 wound healing involved in inflammatory response 2 2 1 1 0 1 0 0 68 2 2477 0.94731 1.0 1.0 0.0 0 0 0 0 0 GO:0002262 5 myeloid cell homeostasis 11 11 1 1 0 1 0 0 68 11 2468 0.74211 1.0 1.0 0.0 0 0 0 0 0 GO:0002320 6 lymphoid progenitor cell differentiation 6 6 1 1 0 0 0 0 68 6 2473 0.84999 1.0 1.0 0.0 0 0 0 0 0 GO:0002328 7 pro-B cell differentiation 2 2 1 1 0 0 0 0 68 2 2477 0.94731 1.0 1.0 0.0 0 0 0 0 0 GO:0002378 6 immunoglobulin biosynthetic process 1 1 1 1 1 0 0 0 68 1 2478 0.9733 1.0 1.0 0.0 0 0 0 0 0 GO:0002437 4 inflammatory response to antigenic stimulus 15 19 2 2 1 0 0 0 68 19 2460 0.5969 1.0 1.0 0.0 0 0 0 0 0 GO:0002438 5 acute inflammatory response to antigenic stimulus 7 9 1 1 0 0 0 0 68 9 2470 0.78354 1.0 1.0 0.0 0 0 0 0 0 GO:0002443 4 leukocyte mediated immunity 28 33 1 1 0 0 0 0 68 33 2446 0.40708 1.0 1.0 0.0 0 0 0 0 0 GO:0002444 5 myeloid leukocyte mediated immunity 5 7 1 1 0 0 0 0 68 7 2472 0.82725 1.0 1.0 0.0 0 0 0 0 0 GO:0002445 7 type II hypersensitivity 1 2 1 1 0 0 0 0 68 2 2477 0.94731 1.0 1.0 0.0 0 0 0 0 0 GO:0002449 5 lymphocyte mediated immunity 23 27 1 1 0 0 0 0 68 27 2452 0.47977 1.0 1.0 0.0 0 0 0 0 0 GO:0002460 5 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains 29 33 1 1 0 0 0 0 68 33 2446 0.40708 1.0 1.0 0.0 0 0 0 0 0 GO:0002474 5 antigen processing and presentation of peptide antigen via MHC class I 11 18 1 1 0 0 0 0 68 18 2461 0.61339 1.0 1.0 0.0 0 0 0 0 0 GO:0002478 5 antigen processing and presentation of exogenous peptide antigen 11 15 1 1 0 0 0 0 68 15 2464 0.66561 1.0 1.0 0.0 0 0 0 0 0 GO:0002501 8 peptide antigen assembly with MHC protein complex 3 5 1 1 0 1 0 0 68 5 2474 0.87336 1.0 1.0 0.0 0 0 0 0 0 GO:0002503 9 peptide antigen assembly with MHC class II protein complex 2 4 1 1 0 1 0 0 68 4 2475 0.89735 1.0 1.0 0.0 0 0 0 0 0 GO:0002504 4 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II 7 9 1 1 0 1 0 0 68 9 2470 0.78354 1.0 1.0 0.0 0 0 0 0 0 GO:0002521 5 leukocyte differentiation 80 87 3 3 1 0 0 0 68 87 2392 0.091123 1.0 0.17135 0.0 0 0 0 0 0 GO:0002523 6 leukocyte migration involved in inflammatory response 9 10 1 1 0 1 0 0 68 10 2469 0.76254 1.0 1.0 0.0 0 0 0 0 0 GO:0002524 6 hypersensitivity 3 4 1 1 0 0 0 0 68 4 2475 0.89735 1.0 1.0 0.0 0 0 0 0 0 GO:0002526 6 acute inflammatory response 39 43 2 2 0 0 0 0 68 43 2436 0.3093 1.0 0.6289 0.0 0 0 0 0 0 GO:0002573 6 myeloid leukocyte differentiation 36 39 1 1 0 0 0 0 68 39 2440 0.34527 1.0 0.62489 0.0 0 0 0 0 0 GO:0002577 5 regulation of antigen processing and presentation 7 7 1 1 1 0 0 0 68 7 2472 0.82725 1.0 1.0 0.0 0 0 0 0 0 GO:0002578 6 negative regulation of antigen processing and presentation 2 2 1 1 1 0 0 0 68 2 2477 0.94731 1.0 1.0 0.0 0 0 0 0 0 GO:0002604 6 regulation of dendritic cell antigen processing and presentation 5 5 1 1 1 0 0 0 68 5 2474 0.87336 1.0 1.0 0.0 0 0 0 0 0 GO:0002605 7 negative regulation of dendritic cell antigen processing and presentation 2 2 1 1 1 0 0 0 68 2 2477 0.94731 1.0 1.0 0.0 0 0 0 0 0 GO:0002637 7 regulation of immunoglobulin production 16 17 1 1 1 0 0 0 68 17 2462 0.63033 1.0 1.0 0.0 0 0 0 0 0 GO:0002639 8 positive regulation of immunoglobulin production 15 15 1 1 1 0 0 0 68 15 2464 0.66561 1.0 1.0 0.0 0 0 0 0 0 GO:0002686 6 negative regulation of leukocyte migration 11 12 1 1 0 1 0 0 68 12 2467 0.72221 1.0 1.0 0.0 0 0 0 0 0 GO:0002689 7 negative regulation of leukocyte chemotaxis 3 4 1 1 0 1 0 0 68 4 2475 0.89735 1.0 1.0 0.0 0 0 0 0 0 GO:0002702 7 positive regulation of production of molecular mediator of immune response 35 38 1 1 1 0 0 0 68 38 2441 0.35488 1.0 0.62448 0.0 0 0 0 0 0 GO:0002711 9 positive regulation of T cell mediated immunity 19 26 1 1 1 0 0 0 68 26 2453 0.49307 1.0 1.0 0.0 0 0 0 0 0 GO:0002761 7 regulation of myeloid leukocyte differentiation 45 48 1 1 0 0 0 0 68 48 2431 0.26949 1.0 0.63832 0.0 0 0 0 0 0 GO:0002763 8 positive regulation of myeloid leukocyte differentiation 25 28 1 1 0 0 0 0 68 28 2451 0.46682 1.0 1.0 0.0 0 0 0 0 0 GO:0002792 7 negative regulation of peptide secretion 35 37 2 2 0 1 0 0 68 37 2442 0.36477 1.0 0.62433 0.0 0 0 0 0 0 GO:0002887 8 negative regulation of myeloid leukocyte mediated immunity 2 2 1 1 0 1 0 0 68 2 2477 0.94731 1.0 1.0 0.0 0 0 0 0 0 GO:0002923 7 regulation of humoral immune response mediated by circulating immunoglobulin 6 7 1 1 1 0 0 0 68 7 2472 0.82725 1.0 1.0 0.0 0 0 0 0 0 GO:0002925 8 positive regulation of humoral immune response mediated by circulating immunoglobulin 2 3 1 1 1 0 0 0 68 3 2476 0.922 1.0 1.0 0.0 0 0 0 0 0 GO:0002931 4 response to ischemia 27 28 1 1 0 0 0 0 68 28 2451 0.46682 1.0 1.0 0.0 0 0 0 0 0 GO:0003009 7 skeletal muscle contraction 14 16 1 1 0 1 0 0 68 16 2463 0.64774 1.0 1.0 0.0 0 0 0 0 0 GO:0003014 4 renal system process 24 25 2 2 0 1 0 0 68 25 2454 0.50673 1.0 1.0 0.0 0 0 0 0 0 GO:0003044 6 regulation of systemic arterial blood pressure mediated by a chemical signal 9 12 1 1 0 1 0 0 68 12 2467 0.72221 1.0 1.0 0.0 0 0 0 0 0 GO:0003071 5 renal system process involved in regulation of systemic arterial blood pressure 6 7 1 1 0 1 0 0 68 7 2472 0.82725 1.0 1.0 0.0 0 0 0 0 0 GO:0003073 5 regulation of systemic arterial blood pressure 15 18 1 1 0 1 0 0 68 18 2461 0.61339 1.0 1.0 0.0 0 0 0 0 0 GO:0003081 7 regulation of systemic arterial blood pressure by renin-angiotensin 3 5 1 1 0 1 0 0 68 5 2474 0.87336 1.0 1.0 0.0 0 0 0 0 0 GO:0003151 4 outflow tract morphogenesis 14 16 1 1 0 0 0 0 68 16 2463 0.64774 1.0 1.0 0.0 0 0 0 0 0 GO:0003179 4 heart valve morphogenesis 13 13 1 1 0 0 0 0 68 13 2466 0.70283 1.0 1.0 0.0 0 0 0 0 0 GO:0003181 5 atrioventricular valve morphogenesis 5 5 1 1 0 0 0 0 68 5 2474 0.87336 1.0 1.0 0.0 0 0 0 0 0 GO:0003183 6 mitral valve morphogenesis 1 1 1 1 0 0 0 0 68 1 2478 0.9733 1.0 1.0 0.0 0 0 0 0 0 GO:0003206 4 cardiac chamber morphogenesis 10 11 1 1 0 0 0 0 68 11 2468 0.74211 1.0 1.0 0.0 0 0 0 0 0 GO:0003207 4 cardiac chamber formation 3 3 1 1 0 0 0 0 68 3 2476 0.922 1.0 1.0 0.0 0 0 0 0 0 GO:0003208 5 cardiac ventricle morphogenesis 9 10 1 1 0 0 0 0 68 10 2469 0.76254 1.0 1.0 0.0 0 0 0 0 0 GO:0003211 5 cardiac ventricle formation 3 3 1 1 0 0 0 0 68 3 2476 0.922 1.0 1.0 0.0 0 0 0 0 0 GO:0003215 6 cardiac right ventricle morphogenesis 4 4 1 1 0 0 0 0 68 4 2475 0.89735 1.0 1.0 0.0 0 0 0 0 0 GO:0003289 6 atrial septum primum morphogenesis 1 1 1 1 0 0 0 0 68 1 2478 0.9733 1.0 1.0 0.0 0 0 0 0 0 GO:0003323 8 type B pancreatic cell development 4 4 1 0 0 0 0 0 68 4 2475 0.89735 1.0 1.0 0.0 0 0 0 0 0 GO:0003357 6 noradrenergic neuron differentiation 1 1 1 1 0 0 0 0 68 1 2478 0.9733 1.0 1.0 0.0 0 0 0 0 0 GO:0006091 4 generation of precursor metabolites and energy 77 85 1 1 0 1 0 0 68 85 2394 0.096375 1.0 0.17053 0.0 0 0 0 0 0 GO:0006342 8 chromatin silencing 6 9 1 1 1 0 0 0 68 9 2470 0.78354 1.0 1.0 0.0 0 0 0 0 0 GO:0006364 9 rRNA processing 22 29 1 1 1 0 0 0 68 29 2450 0.45422 1.0 1.0 0.0 0 0 0 0 0 GO:0006366 8 transcription by RNA polymerase II 35 40 1 1 0 0 0 0 68 40 2439 0.3359 1.0 0.62555 0.0 0 0 0 0 0 GO:0006396 7 RNA processing 67 78 2 2 1 1 0 0 68 78 2401 0.11721 1.0 0.27011 0.0 0 0 0 0 0 GO:0006401 6 RNA catabolic process 23 25 1 1 1 0 0 0 68 25 2454 0.50673 1.0 1.0 0.0 0 0 0 0 0 GO:0006402 7 mRNA catabolic process 19 21 1 1 1 0 0 0 68 21 2458 0.56521 1.0 1.0 0.0 0 0 0 0 0 GO:0006417 7 regulation of translation 60 67 3 2 0 0 0 0 68 67 2412 0.15924 1.0 0.26088 0.0 0 0 0 0 0 GO:0006446 8 regulation of translational initiation 12 17 1 1 0 0 0 0 68 17 2462 0.63033 1.0 1.0 0.0 0 0 0 0 0 GO:0006458 4 'de novo' protein folding 13 17 1 1 0 0 0 0 68 17 2462 0.63033 1.0 1.0 0.0 0 0 0 0 0 GO:0006470 7 protein dephosphorylation 27 33 4 4 2 1 0 0 68 33 2446 0.40708 1.0 1.0 0.0 0 0 0 0 0 GO:0006477 6 protein sulfation 1 1 1 1 0 1 0 0 68 1 2478 0.9733 1.0 1.0 0.0 0 0 0 0 0 GO:0006584 6 catecholamine metabolic process 12 14 1 1 0 1 0 0 68 14 2465 0.68397 1.0 1.0 0.0 0 0 0 0 0 GO:0006590 6 thyroid hormone generation 4 5 1 1 0 0 0 0 68 5 2474 0.87336 1.0 1.0 0.0 0 0 0 0 0 GO:0006661 7 phosphatidylinositol biosynthetic process 11 12 1 1 1 0 0 0 68 12 2467 0.72221 1.0 1.0 0.0 0 0 0 0 0 GO:0006702 7 androgen biosynthetic process 4 4 1 1 0 1 0 0 68 4 2475 0.89735 1.0 1.0 0.0 0 0 0 0 0 GO:0006706 6 steroid catabolic process 12 14 2 2 0 1 0 0 68 14 2465 0.68397 1.0 1.0 0.0 0 0 0 0 0 GO:0006710 6 androgen catabolic process 4 4 2 2 0 1 0 0 68 4 2475 0.89735 1.0 1.0 0.0 0 0 0 0 0 GO:0006730 4 one-carbon metabolic process 9 10 1 1 1 0 0 0 68 10 2469 0.76254 1.0 1.0 0.0 0 0 0 0 0 GO:0006739 3 NADP metabolic process 12 12 1 1 1 0 0 0 68 12 2467 0.72221 1.0 1.0 0.0 0 0 0 0 0 GO:0006760 5 folic acid-containing compound metabolic process 6 7 1 1 1 0 0 0 68 7 2472 0.82725 1.0 1.0 0.0 0 0 0 0 0 GO:0006779 6 porphyrin-containing compound biosynthetic process 8 8 1 1 1 0 0 0 68 8 2471 0.8051 1.0 1.0 0.0 0 0 0 0 0 GO:0006782 7 protoporphyrinogen IX biosynthetic process 4 4 1 1 1 0 0 0 68 4 2475 0.89735 1.0 1.0 0.0 0 0 0 0 0 GO:0006783 6 heme biosynthetic process 7 7 1 1 1 0 0 0 68 7 2472 0.82725 1.0 1.0 0.0 0 0 0 0 0 GO:0006788 6 heme oxidation 1 1 1 1 0 1 0 0 68 1 2478 0.9733 1.0 1.0 0.0 0 0 0 0 0 GO:0006816 9 calcium ion transport 54 57 2 2 1 1 0 0 68 57 2422 0.21015 1.0 0.40365 0.0 0 0 0 0 0 GO:0006825 9 copper ion transport 4 4 1 1 0 1 0 0 68 4 2475 0.89735 1.0 1.0 0.0 0 0 0 0 0 GO:0006826 9 iron ion transport 11 11 1 1 0 1 0 0 68 11 2468 0.74211 1.0 1.0 0.0 0 0 0 0 0 GO:0006879 10 cellular iron ion homeostasis 15 15 3 2 1 1 0 0 68 15 2464 0.66561 1.0 1.0 0.0 0 0 0 0 0 GO:0006883 9 cellular sodium ion homeostasis 4 4 1 1 0 0 0 0 68 4 2475 0.89735 1.0 1.0 0.0 0 0 0 0 0 GO:0006885 9 regulation of pH 14 15 1 1 0 1 0 0 68 15 2464 0.66561 1.0 1.0 0.0 0 0 0 0 0 GO:0006897 5 endocytosis 72 75 2 2 1 0 0 0 68 75 2404 0.12745 1.0 0.26549 0.0 0 0 0 0 0 GO:0006898 6 receptor-mediated endocytosis 38 39 1 1 0 0 0 0 68 39 2440 0.34527 1.0 0.62489 0.0 0 0 0 0 0 GO:0006900 6 vesicle budding from membrane 10 10 1 1 0 1 0 0 68 10 2469 0.76254 1.0 1.0 0.0 0 0 0 0 0 GO:0006910 4 phagocytosis, recognition 8 9 2 2 0 1 0 0 68 9 2470 0.78354 1.0 1.0 0.0 0 0 0 0 0 GO:0006911 8 phagocytosis, engulfment 7 8 1 1 0 0 0 0 68 8 2471 0.8051 1.0 1.0 0.0 0 0 0 0 0 GO:0006933 7 negative regulation of cell adhesion involved in substrate-bound cell migration 2 2 1 1 1 0 0 0 68 2 2477 0.94731 1.0 1.0 0.0 0 0 0 0 0 GO:0006936 5 muscle contraction 49 51 1 1 0 1 0 0 68 51 2428 0.24807 1.0 0.64581 0.0 0 0 0 0 0 GO:0006941 6 striated muscle contraction 34 36 1 1 0 1 0 0 68 36 2443 0.37492 1.0 0.62447 0.0 0 0 0 0 0 GO:0006953 7 acute-phase response 25 27 1 1 0 0 0 0 68 27 2452 0.47977 1.0 1.0 0.0 0 0 0 0 0 GO:0006977 8 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest 5 5 1 1 0 0 0 0 68 5 2474 0.87336 1.0 1.0 0.0 0 0 0 0 0 GO:0006998 6 nuclear envelope organization 6 8 1 1 1 0 0 0 68 8 2471 0.8051 1.0 1.0 0.0 0 0 0 0 0 GO:0007033 6 vacuole organization 22 22 1 1 1 0 0 0 68 22 2457 0.55 1.0 1.0 0.0 0 0 0 0 0 GO:0007050 6 cell cycle arrest 22 23 1 1 0 1 0 0 68 23 2456 0.53518 1.0 1.0 0.0 0 0 0 0 0 GO:0007127 7 meiosis I 8 8 1 1 0 1 0 0 68 8 2471 0.8051 1.0 1.0 0.0 0 0 0 0 0 GO:0007129 6 synapsis 2 2 1 1 0 0 0 0 68 2 2477 0.94731 1.0 1.0 0.0 0 0 0 0 0 GO:0007141 8 male meiosis I 3 3 1 1 0 1 0 0 68 3 2476 0.922 1.0 1.0 0.0 0 0 0 0 0 GO:0007161 6 calcium-independent cell-matrix adhesion 2 2 1 1 0 0 0 0 68 2 2477 0.94731 1.0 1.0 0.0 0 0 0 0 0 GO:0007169 7 transmembrane receptor protein tyrosine kinase signaling pathway 107 112 3 3 0 2 0 0 68 112 2367 0.045057 1.0 0.072847 0.0 0 0 0 0 0 GO:0007200 6 phospholipase C-activating G protein-coupled receptor signaling pathway 12 13 1 1 0 1 0 0 68 13 2466 0.70283 1.0 1.0 0.0 0 0 0 0 0 GO:0007212 5 dopamine receptor signaling pathway 9 9 1 1 1 0 0 0 68 9 2470 0.78354 1.0 1.0 0.0 0 0 0 0 0 GO:0007215 6 glutamate receptor signaling pathway 19 19 1 1 0 0 0 0 68 19 2460 0.5969 1.0 1.0 0.0 0 0 0 0 0 GO:0007266 8 Rho protein signal transduction 11 12 1 1 0 1 0 0 68 12 2467 0.72221 1.0 1.0 0.0 0 0 0 0 0 GO:0007369 5 gastrulation 15 17 1 1 0 0 0 0 68 17 2462 0.63033 1.0 1.0 0.0 0 0 0 0 0 GO:0007548 4 sex differentiation 7 7 1 1 0 1 0 0 68 7 2472 0.82725 1.0 1.0 0.0 0 0 0 0 0 GO:0007600 5 sensory perception 62 65 2 2 1 1 0 0 68 65 2414 0.16834 1.0 0.41848 0.0 0 0 0 0 0 GO:0007612 6 learning 40 43 2 2 1 0 0 0 68 43 2436 0.3093 1.0 0.6289 0.0 0 0 0 0 0 GO:0007613 6 memory 40 41 1 1 1 0 0 0 68 41 2438 0.32679 1.0 0.62644 0.0 0 0 0 0 0 GO:0007631 3 feeding behavior 14 16 1 1 0 1 0 0 68 16 2463 0.64774 1.0 1.0 0.0 0 0 0 0 0 GO:0008016 7 regulation of heart contraction 36 40 1 0 0 0 0 0 68 40 2439 0.3359 1.0 0.62555 0.0 0 0 0 0 0 GO:0008037 3 cell recognition 38 40 2 2 0 1 0 0 68 40 2439 0.3359 1.0 0.62555 0.0 0 0 0 0 0 GO:0008207 6 C21-steroid hormone metabolic process 8 12 1 1 0 1 0 0 68 12 2467 0.72221 1.0 1.0 0.0 0 0 0 0 0 GO:0008217 4 regulation of blood pressure 48 54 3 3 1 2 0 0 68 54 2425 0.22834 1.0 0.40155 0.0 0 0 0 0 0 GO:0008347 5 glial cell migration 8 8 2 2 0 1 0 0 68 8 2471 0.8051 1.0 1.0 0.0 0 0 0 0 0 GO:0008406 5 gonad development 45 49 2 2 0 2 0 0 68 49 2430 0.26216 1.0 0.64068 0.0 0 0 0 0 0 GO:0008584 6 male gonad development 41 45 2 2 0 2 0 0 68 45 2434 0.29272 1.0 0.63214 0.0 0 0 0 0 0 GO:0008608 4 attachment of spindle microtubules to kinetochore 5 7 1 1 0 0 0 0 68 7 2472 0.82725 1.0 1.0 0.0 0 0 0 0 0 GO:0008630 7 intrinsic apoptotic signaling pathway in response to DNA damage 37 38 2 2 1 1 0 0 68 38 2441 0.35488 1.0 0.62448 0.0 0 0 0 0 0 GO:0008637 7 apoptotic mitochondrial changes 27 27 1 1 0 0 0 0 68 27 2452 0.47977 1.0 1.0 0.0 0 0 0 0 0 GO:0009581 4 detection of external stimulus 25 26 1 1 0 0 0 0 68 26 2453 0.49307 1.0 1.0 0.0 0 0 0 0 0 GO:0009582 4 detection of abiotic stimulus 25 26 1 1 0 0 0 0 68 26 2453 0.49307 1.0 1.0 0.0 0 0 0 0 0 GO:0009712 6 catechol-containing compound metabolic process 12 14 1 1 0 1 0 0 68 14 2465 0.68397 1.0 1.0 0.0 0 0 0 0 0 GO:0009713 7 catechol-containing compound biosynthetic process 8 8 1 1 0 1 0 0 68 8 2471 0.8051 1.0 1.0 0.0 0 0 0 0 0 GO:0010001 5 glial cell differentiation 30 32 1 1 0 1 0 0 68 32 2447 0.41839 1.0 1.0 0.0 0 0 0 0 0 GO:0010193 5 response to ozone 6 6 1 1 0 0 0 0 68 6 2473 0.84999 1.0 1.0 0.0 0 0 0 0 0 GO:0010224 7 response to UV-B 7 8 1 1 1 0 0 0 68 8 2471 0.8051 1.0 1.0 0.0 0 0 0 0 0 GO:0010226 6 response to lithium ion 21 24 1 1 1 0 0 0 68 24 2455 0.52077 1.0 1.0 0.0 0 0 0 0 0 GO:0010288 6 response to lead ion 24 26 3 3 2 1 0 0 68 26 2453 0.49307 1.0 1.0 0.0 0 0 0 0 0 GO:0010324 6 membrane invagination 10 11 1 1 0 0 0 0 68 11 2468 0.74211 1.0 1.0 0.0 0 0 0 0 0 GO:0010335 5 response to non-ionic osmotic stress 1 1 1 1 1 0 0 0 68 1 2478 0.9733 1.0 1.0 0.0 0 0 0 0 0 GO:0010464 6 regulation of mesenchymal cell proliferation 11 11 1 1 0 1 0 0 68 11 2468 0.74211 1.0 1.0 0.0 0 0 0 0 0 GO:0010467 5 gene expression 44 44 2 2 1 1 0 0 68 44 2435 0.3009 1.0 0.63043 0.0 0 0 0 0 0 GO:0010469 4 regulation of signaling receptor activity 28 32 1 1 0 1 0 0 68 32 2447 0.41839 1.0 1.0 0.0 0 0 0 0 0 GO:0010508 8 positive regulation of autophagy 35 37 2 2 0 2 0 0 68 37 2442 0.36477 1.0 0.62433 0.0 0 0 0 0 0 GO:0010511 8 regulation of phosphatidylinositol biosynthetic process 4 4 1 1 0 1 0 0 68 4 2475 0.89735 1.0 1.0 0.0 0 0 0 0 0 GO:0010512 9 negative regulation of phosphatidylinositol biosynthetic process 2 2 1 1 0 1 0 0 68 2 2477 0.94731 1.0 1.0 0.0 0 0 0 0 0 GO:0010517 7 regulation of phospholipase activity 14 15 2 1 0 1 0 0 68 15 2464 0.66561 1.0 1.0 0.0 0 0 0 0 0 GO:0010518 8 positive regulation of phospholipase activity 10 10 1 1 0 1 0 0 68 10 2469 0.76254 1.0 1.0 0.0 0 0 0 0 0 GO:0010519 8 negative regulation of phospholipase activity 3 4 1 0 0 0 0 0 68 4 2475 0.89735 1.0 1.0 0.0 0 0 0 0 0 GO:0010523 5 negative regulation of calcium ion transport into cytosol 6 6 1 1 0 0 0 0 68 6 2473 0.84999 1.0 1.0 0.0 0 0 0 0 0 GO:0010528 5 regulation of transposition 1 1 1 1 0 1 0 0 68 1 2478 0.9733 1.0 1.0 0.0 0 0 0 0 0 GO:0010529 6 negative regulation of transposition 1 1 1 1 0 1 0 0 68 1 2478 0.9733 1.0 1.0 0.0 0 0 0 0 0 GO:0010566 7 regulation of ketone biosynthetic process 4 4 1 0 0 0 0 0 68 4 2475 0.89735 1.0 1.0 0.0 0 0 0 0 0 GO:0010596 7 negative regulation of endothelial cell migration 17 18 1 1 0 1 0 0 68 18 2461 0.61339 1.0 1.0 0.0 0 0 0 0 0 GO:0010608 7 posttranscriptional regulation of gene expression 70 78 4 3 1 0 0 0 68 78 2401 0.11721 1.0 0.27011 0.0 0 0 0 0 0 GO:0010611 6 regulation of cardiac muscle hypertrophy 26 26 1 0 0 0 0 0 68 26 2453 0.49307 1.0 1.0 0.0 0 0 0 0 0 GO:0010614 7 negative regulation of cardiac muscle hypertrophy 10 10 1 0 0 0 0 0 68 10 2469 0.76254 1.0 1.0 0.0 0 0 0 0 0 GO:0010633 6 negative regulation of epithelial cell migration 18 21 1 1 0 1 0 0 68 21 2458 0.56521 1.0 1.0 0.0 0 0 0 0 0 GO:0010714 6 positive regulation of collagen metabolic process 15 15 1 1 0 1 0 0 68 15 2464 0.66561 1.0 1.0 0.0 0 0 0 0 0 GO:0010758 7 regulation of macrophage chemotaxis 10 11 1 1 0 1 0 0 68 11 2468 0.74211 1.0 1.0 0.0 0 0 0 0 0 GO:0010759 7 positive regulation of macrophage chemotaxis 8 8 1 1 0 1 0 0 68 8 2471 0.8051 1.0 1.0 0.0 0 0 0 0 0 GO:0010799 9 regulation of peptidyl-threonine phosphorylation 13 15 1 1 1 0 0 0 68 15 2464 0.66561 1.0 1.0 0.0 0 0 0 0 0 GO:0010800 10 positive regulation of peptidyl-threonine phosphorylation 10 11 1 1 1 0 0 0 68 11 2468 0.74211 1.0 1.0 0.0 0 0 0 0 0 GO:0010837 7 regulation of keratinocyte proliferation 7 8 1 1 1 0 0 0 68 8 2471 0.8051 1.0 1.0 0.0 0 0 0 0 0 GO:0010838 8 positive regulation of keratinocyte proliferation 3 3 1 1 1 0 0 0 68 3 2476 0.922 1.0 1.0 0.0 0 0 0 0 0 GO:0010862 8 positive regulation of pathway-restricted SMAD protein phosphorylation 15 15 1 0 0 0 0 0 68 15 2464 0.66561 1.0 1.0 0.0 0 0 0 0 0 GO:0010872 6 regulation of cholesterol esterification 4 4 1 1 0 1 0 0 68 4 2475 0.89735 1.0 1.0 0.0 0 0 0 0 0 GO:0010873 7 positive regulation of cholesterol esterification 4 4 1 1 0 1 0 0 68 4 2475 0.89735 1.0 1.0 0.0 0 0 0 0 0 GO:0010893 8 positive regulation of steroid biosynthetic process 18 20 1 0 0 0 0 0 68 20 2459 0.58084 1.0 1.0 0.0 0 0 0 0 0 GO:0010921 7 regulation of phosphatase activity 30 35 2 2 2 0 0 0 68 35 2444 0.38535 1.0 1.0 0.0 0 0 0 0 0 GO:0010922 8 positive regulation of phosphatase activity 12 14 1 1 1 0 0 0 68 14 2465 0.68397 1.0 1.0 0.0 0 0 0 0 0 GO:0010923 8 negative regulation of phosphatase activity 13 16 1 1 1 0 0 0 68 16 2463 0.64774 1.0 1.0 0.0 0 0 0 0 0 GO:0010939 6 regulation of necrotic cell death 13 13 1 1 0 0 0 0 68 13 2466 0.70283 1.0 1.0 0.0 0 0 0 0 0 GO:0010952 7 positive regulation of peptidase activity 63 67 1 1 0 0 0 0 68 67 2412 0.15924 1.0 0.26088 0.0 0 0 0 0 0 GO:0010955 9 negative regulation of protein processing 15 15 1 1 0 0 0 0 68 15 2464 0.66561 1.0 1.0 0.0 0 0 0 0 0 GO:0010958 9 regulation of amino acid import across plasma membrane 3 4 1 0 0 0 0 0 68 4 2475 0.89735 1.0 1.0 0.0 0 0 0 0 0 GO:0010999 6 regulation of eIF2 alpha phosphorylation by heme 1 1 1 1 0 0 0 0 68 1 2478 0.9733 1.0 1.0 0.0 0 0 0 0 0 GO:0014012 8 peripheral nervous system axon regeneration 7 7 1 1 0 1 0 0 68 7 2472 0.82725 1.0 1.0 0.0 0 0 0 0 0 GO:0014065 8 phosphatidylinositol 3-kinase signaling 12 13 1 1 1 0 0 0 68 13 2466 0.70283 1.0 1.0 0.0 0 0 0 0 0 GO:0014733 6 regulation of skeletal muscle adaptation 3 3 1 1 0 1 0 0 68 3 2476 0.922 1.0 1.0 0.0 0 0 0 0 0 GO:0014741 6 negative regulation of muscle hypertrophy 10 10 1 0 0 0 0 0 68 10 2469 0.76254 1.0 1.0 0.0 0 0 0 0 0 GO:0014743 7 regulation of muscle hypertrophy 26 26 1 0 0 0 0 0 68 26 2453 0.49307 1.0 1.0 0.0 0 0 0 0 0 GO:0014850 4 response to muscle activity 13 13 1 1 0 1 0 0 68 13 2466 0.70283 1.0 1.0 0.0 0 0 0 0 0 GO:0014883 7 transition between fast and slow fiber 3 3 1 1 0 1 0 0 68 3 2476 0.922 1.0 1.0 0.0 0 0 0 0 0 GO:0015669 5 gas transport 4 7 2 2 1 0 0 0 68 7 2472 0.82725 1.0 1.0 0.0 0 0 0 0 0 GO:0015671 6 oxygen transport 4 7 2 2 1 0 0 0 68 7 2472 0.82725 1.0 1.0 0.0 0 0 0 0 0 GO:0015677 10 copper ion import 2 2 1 1 0 1 0 0 68 2 2477 0.94731 1.0 1.0 0.0 0 0 0 0 0 GO:0015721 7 bile acid and bile salt transport 18 18 1 1 1 0 0 0 68 18 2461 0.61339 1.0 1.0 0.0 0 0 0 0 0 GO:0015732 8 prostaglandin transport 2 3 1 1 0 1 0 0 68 3 2476 0.922 1.0 1.0 0.0 0 0 0 0 0 GO:0016048 5 detection of temperature stimulus 6 6 1 1 0 0 0 0 68 6 2473 0.84999 1.0 1.0 0.0 0 0 0 0 0 GO:0016050 6 vesicle organization 36 39 1 1 0 1 0 0 68 39 2440 0.34527 1.0 0.62489 0.0 0 0 0 0 0 GO:0016055 7 Wnt signaling pathway 31 35 2 2 2 0 0 0 68 35 2444 0.38535 1.0 1.0 0.0 0 0 0 0 0 GO:0016064 7 immunoglobulin mediated immune response 10 12 1 1 0 0 0 0 68 12 2467 0.72221 1.0 1.0 0.0 0 0 0 0 0 GO:0016072 8 rRNA metabolic process 23 30 1 1 1 0 0 0 68 30 2449 0.44195 1.0 1.0 0.0 0 0 0 0 0 GO:0016197 4 endosomal transport 21 21 1 1 1 0 0 0 68 21 2458 0.56521 1.0 1.0 0.0 0 0 0 0 0 GO:0016239 9 positive regulation of macroautophagy 19 21 2 2 0 2 0 0 68 21 2458 0.56521 1.0 1.0 0.0 0 0 0 0 0 GO:0016241 8 regulation of macroautophagy 26 28 2 2 0 2 0 0 68 28 2451 0.46682 1.0 1.0 0.0 0 0 0 0 0 GO:0016242 9 negative regulation of macroautophagy 7 7 1 1 0 1 0 0 68 7 2472 0.82725 1.0 1.0 0.0 0 0 0 0 0 GO:0016311 6 dephosphorylation 44 50 5 5 3 1 0 0 68 50 2429 0.25502 1.0 0.64318 0.0 0 0 0 0 0 GO:0016339 6 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules 8 8 1 1 1 0 0 0 68 8 2471 0.8051 1.0 1.0 0.0 0 0 0 0 0 GO:0016458 7 gene silencing 7 11 1 1 1 0 0 0 68 11 2468 0.74211 1.0 1.0 0.0 0 0 0 0 0 GO:0016573 8 histone acetylation 12 12 1 1 0 0 0 0 68 12 2467 0.72221 1.0 1.0 0.0 0 0 0 0 0 GO:0017148 8 negative regulation of translation 21 22 1 0 0 0 0 0 68 22 2457 0.55 1.0 1.0 0.0 0 0 0 0 0 GO:0018393 10 internal peptidyl-lysine acetylation 13 13 1 1 0 0 0 0 68 13 2466 0.70283 1.0 1.0 0.0 0 0 0 0 0 GO:0018394 9 peptidyl-lysine acetylation 13 13 1 1 0 0 0 0 68 13 2466 0.70283 1.0 1.0 0.0 0 0 0 0 0 GO:0018916 5 nitrobenzene metabolic process 2 4 1 1 0 0 0 0 68 4 2475 0.89735 1.0 1.0 0.0 0 0 0 0 0 GO:0018958 5 phenol-containing compound metabolic process 27 31 3 3 0 2 0 0 68 31 2448 0.43001 1.0 1.0 0.0 0 0 0 0 0 GO:0019228 6 neuronal action potential 4 4 1 1 0 0 0 0 68 4 2475 0.89735 1.0 1.0 0.0 0 0 0 0 0 GO:0019233 6 sensory perception of pain 16 17 2 2 1 1 0 0 68 17 2462 0.63033 1.0 1.0 0.0 0 0 0 0 0 GO:0019371 7 cyclooxygenase pathway 3 3 1 1 1 0 0 0 68 3 2476 0.922 1.0 1.0 0.0 0 0 0 0 0 GO:0019724 6 B cell mediated immunity 12 14 1 1 0 0 0 0 68 14 2465 0.68397 1.0 1.0 0.0 0 0 0 0 0 GO:0019800 7 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan 2 2 2 2 0 1 0 0 68 2 2477 0.94731 1.0 1.0 0.0 0 0 0 0 0 GO:0019827 3 stem cell population maintenance 26 27 1 1 0 0 0 0 68 27 2452 0.47977 1.0 1.0 0.0 0 0 0 0 0 GO:0019882 3 antigen processing and presentation 24 35 2 2 0 1 0 0 68 35 2444 0.38535 1.0 1.0 0.0 0 0 0 0 0 GO:0019884 4 antigen processing and presentation of exogenous antigen 12 17 1 1 0 0 0 0 68 17 2462 0.63033 1.0 1.0 0.0 0 0 0 0 0 GO:0020027 5 hemoglobin metabolic process 8 8 1 1 1 0 0 0 68 8 2471 0.8051 1.0 1.0 0.0 0 0 0 0 0 GO:0021510 5 spinal cord development 11 11 2 2 0 1 0 0 68 11 2468 0.74211 1.0 1.0 0.0 0 0 0 0 0 GO:0021515 5 cell differentiation in spinal cord 11 11 1 1 0 0 0 0 68 11 2468 0.74211 1.0 1.0 0.0 0 0 0 0 0 GO:0021522 6 spinal cord motor neuron differentiation 7 7 1 1 0 0 0 0 68 7 2472 0.82725 1.0 1.0 0.0 0 0 0 0 0 GO:0021766 4 hippocampus development 31 35 1 1 0 1 0 0 68 35 2444 0.38535 1.0 1.0 0.0 0 0 0 0 0 GO:0021794 4 thalamus development 1 1 1 1 0 1 0 0 68 1 2478 0.9733 1.0 1.0 0.0 0 0 0 0 0 GO:0021854 4 hypothalamus development 7 7 1 1 0 1 0 0 68 7 2472 0.82725 1.0 1.0 0.0 0 0 0 0 0 GO:0021983 6 pituitary gland development 8 10 1 1 0 1 0 0 68 10 2469 0.76254 1.0 1.0 0.0 0 0 0 0 0 GO:0022404 3 molting cycle process 15 17 2 2 1 1 0 0 68 17 2462 0.63033 1.0 1.0 0.0 0 0 0 0 0 GO:0022405 4 hair cycle process 15 17 2 2 1 1 0 0 68 17 2462 0.63033 1.0 1.0 0.0 0 0 0 0 0 GO:0022410 5 circadian sleep/wake cycle process 3 3 1 1 0 1 0 0 68 3 2476 0.922 1.0 1.0 0.0 0 0 0 0 0 GO:0022900 4 electron transport chain 24 26 1 1 0 1 0 0 68 26 2453 0.49307 1.0 1.0 0.0 0 0 0 0 0 GO:0023061 6 signal release 45 48 3 3 0 3 0 0 68 48 2431 0.26949 1.0 0.63832 0.0 0 0 0 0 0 GO:0030002 7 cellular anion homeostasis 6 6 1 1 0 0 0 0 68 6 2473 0.84999 1.0 1.0 0.0 0 0 0 0 0 GO:0030004 8 cellular monovalent inorganic cation homeostasis 16 17 1 1 0 0 0 0 68 17 2462 0.63033 1.0 1.0 0.0 0 0 0 0 0 GO:0030031 6 cell projection assembly 41 43 3 3 0 3 0 0 68 43 2436 0.3093 1.0 0.6289 0.0 0 0 0 0 0 GO:0030097 6 hemopoiesis 28 29 1 1 0 0 0 0 68 29 2450 0.45422 1.0 1.0 0.0 0 0 0 0 0 GO:0030098 5 lymphocyte differentiation 53 58 2 2 1 0 0 0 68 58 2421 0.20441 1.0 0.40481 0.0 0 0 0 0 0 GO:0030099 5 myeloid cell differentiation 58 64 3 3 2 0 0 0 68 64 2415 0.17308 1.0 0.41598 0.0 0 0 0 0 0 GO:0030101 5 natural killer cell activation 10 10 1 1 1 0 0 0 68 10 2469 0.76254 1.0 1.0 0.0 0 0 0 0 0 GO:0030178 7 negative regulation of Wnt signaling pathway 31 31 1 1 1 0 0 0 68 31 2448 0.43001 1.0 1.0 0.0 0 0 0 0 0 GO:0030183 6 B cell differentiation 16 18 1 1 1 0 0 0 68 18 2461 0.61339 1.0 1.0 0.0 0 0 0 0 0 GO:0030204 6 chondroitin sulfate metabolic process 4 4 2 2 0 1 0 0 68 4 2475 0.89735 1.0 1.0 0.0 0 0 0 0 0 GO:0030217 6 T cell differentiation 40 44 2 2 1 0 0 0 68 44 2435 0.3009 1.0 0.63043 0.0 0 0 0 0 0 GO:0030218 6 erythrocyte differentiation 14 16 1 1 1 0 0 0 68 16 2463 0.64774 1.0 1.0 0.0 0 0 0 0 0 GO:0030224 7 monocyte differentiation 8 8 1 1 0 0 0 0 68 8 2471 0.8051 1.0 1.0 0.0 0 0 0 0 0 GO:0030279 6 negative regulation of ossification 16 19 1 1 1 0 0 0 68 19 2460 0.5969 1.0 1.0 0.0 0 0 0 0 0 GO:0030320 8 cellular monovalent inorganic anion homeostasis 6 6 1 1 0 0 0 0 68 6 2473 0.84999 1.0 1.0 0.0 0 0 0 0 0 GO:0030330 7 DNA damage response, signal transduction by p53 class mediator 13 14 1 1 0 0 0 0 68 14 2465 0.68397 1.0 1.0 0.0 0 0 0 0 0 GO:0030397 6 membrane disassembly 3 3 1 1 1 0 0 0 68 3 2476 0.922 1.0 1.0 0.0 0 0 0 0 0 GO:0030500 6 regulation of bone mineralization 18 20 2 1 0 1 0 0 68 20 2459 0.58084 1.0 1.0 0.0 0 0 0 0 0 GO:0030501 7 positive regulation of bone mineralization 11 12 2 1 0 1 0 0 68 12 2467 0.72221 1.0 1.0 0.0 0 0 0 0 0 GO:0030510 6 regulation of BMP signaling pathway 17 19 1 1 0 0 0 0 68 19 2460 0.5969 1.0 1.0 0.0 0 0 0 0 0 GO:0030539 6 male genitalia development 5 5 2 1 0 1 0 0 68 5 2474 0.87336 1.0 1.0 0.0 0 0 0 0 0 GO:0030540 6 female genitalia development 7 7 1 1 0 1 0 0 68 7 2472 0.82725 1.0 1.0 0.0 0 0 0 0 0 GO:0030643 9 cellular phosphate ion homeostasis 2 2 1 1 0 0 0 0 68 2 2477 0.94731 1.0 1.0 0.0 0 0 0 0 0 GO:0030644 9 cellular chloride ion homeostasis 5 5 1 1 0 0 0 0 68 5 2474 0.87336 1.0 1.0 0.0 0 0 0 0 0 GO:0030888 8 regulation of B cell proliferation 26 28 1 1 1 0 0 0 68 28 2451 0.46682 1.0 1.0 0.0 0 0 0 0 0 GO:0030890 9 positive regulation of B cell proliferation 17 19 1 1 1 0 0 0 68 19 2460 0.5969 1.0 1.0 0.0 0 0 0 0 0 GO:0030900 4 forebrain development 19 20 1 1 0 0 0 0 68 20 2459 0.58084 1.0 1.0 0.0 0 0 0 0 0 GO:0031000 5 response to caffeine 17 17 1 1 0 0 0 0 68 17 2462 0.63033 1.0 1.0 0.0 0 0 0 0 0 GO:0031109 6 microtubule polymerization or depolymerization 11 11 1 1 0 1 0 0 68 11 2468 0.74211 1.0 1.0 0.0 0 0 0 0 0 GO:0031342 6 negative regulation of cell killing 8 9 1 1 1 0 0 0 68 9 2470 0.78354 1.0 1.0 0.0 0 0 0 0 0 GO:0031392 9 regulation of prostaglandin biosynthetic process 5 6 1 1 1 0 0 0 68 6 2473 0.84999 1.0 1.0 0.0 0 0 0 0 0 GO:0031394 10 positive regulation of prostaglandin biosynthetic process 5 6 1 1 1 0 0 0 68 6 2473 0.84999 1.0 1.0 0.0 0 0 0 0 0 GO:0031398 10 positive regulation of protein ubiquitination 34 35 2 2 1 0 0 0 68 35 2444 0.38535 1.0 1.0 0.0 0 0 0 0 0 GO:0031424 3 keratinization 4 4 1 1 1 0 0 0 68 4 2475 0.89735 1.0 1.0 0.0 0 0 0 0 0 GO:0031503 5 protein-containing complex localization 21 22 1 1 1 0 0 0 68 22 2457 0.55 1.0 1.0 0.0 0 0 0 0 0 GO:0031579 6 membrane raft organization 6 6 2 2 1 1 0 0 68 6 2473 0.84999 1.0 1.0 0.0 0 0 0 0 0 GO:0031580 6 membrane raft distribution 1 1 1 1 1 0 0 0 68 1 2478 0.9733 1.0 1.0 0.0 0 0 0 0 0 GO:0031620 5 regulation of fever generation 3 5 1 1 1 0 0 0 68 5 2474 0.87336 1.0 1.0 0.0 0 0 0 0 0 GO:0031622 6 positive regulation of fever generation 3 5 1 1 1 0 0 0 68 5 2474 0.87336 1.0 1.0 0.0 0 0 0 0 0 GO:0031641 5 regulation of myelination 19 21 1 1 0 0 0 0 68 21 2458 0.56521 1.0 1.0 0.0 0 0 0 0 0 GO:0031643 6 positive regulation of myelination 10 10 1 1 0 0 0 0 68 10 2469 0.76254 1.0 1.0 0.0 0 0 0 0 0 GO:0031644 6 regulation of nervous system process 40 41 1 1 0 0 0 0 68 41 2438 0.32679 1.0 0.62644 0.0 0 0 0 0 0 GO:0031646 6 positive regulation of nervous system process 20 20 1 1 0 0 0 0 68 20 2459 0.58084 1.0 1.0 0.0 0 0 0 0 0 GO:0031648 5 protein destabilization 8 11 1 1 1 0 0 0 68 11 2468 0.74211 1.0 1.0 0.0 0 0 0 0 0 GO:0031650 4 regulation of heat generation 6 8 1 1 1 0 0 0 68 8 2471 0.8051 1.0 1.0 0.0 0 0 0 0 0 GO:0031652 5 positive regulation of heat generation 6 8 1 1 1 0 0 0 68 8 2471 0.8051 1.0 1.0 0.0 0 0 0 0 0 GO:0031663 6 lipopolysaccharide-mediated signaling pathway 19 20 1 1 0 1 0 0 68 20 2459 0.58084 1.0 1.0 0.0 0 0 0 0 0 GO:0031664 6 regulation of lipopolysaccharide-mediated signaling pathway 8 9 1 0 0 0 0 0 68 9 2470 0.78354 1.0 1.0 0.0 0 0 0 0 0 GO:0031666 7 positive regulation of lipopolysaccharide-mediated signaling pathway 4 5 1 0 0 0 0 0 68 5 2474 0.87336 1.0 1.0 0.0 0 0 0 0 0 GO:0031952 9 regulation of protein autophosphorylation 18 21 3 3 1 1 0 0 68 21 2458 0.56521 1.0 1.0 0.0 0 0 0 0 0 GO:0031953 10 negative regulation of protein autophosphorylation 7 8 2 2 1 0 0 0 68 8 2471 0.8051 1.0 1.0 0.0 0 0 0 0 0 GO:0031954 10 positive regulation of protein autophosphorylation 9 10 1 1 0 1 0 0 68 10 2469 0.76254 1.0 1.0 0.0 0 0 0 0 0 GO:0032020 7 ISG15-protein conjugation 2 2 1 1 0 1 0 0 68 2 2477 0.94731 1.0 1.0 0.0 0 0 0 0 0 GO:0032025 6 response to cobalt ion 13 13 1 1 1 0 0 0 68 13 2466 0.70283 1.0 1.0 0.0 0 0 0 0 0 GO:0032091 6 negative regulation of protein binding 41 42 2 2 1 1 0 0 68 42 2437 0.31793 1.0 0.62756 0.0 0 0 0 0 0 GO:0032200 7 telomere organization 14 16 1 1 0 0 0 0 68 16 2463 0.64774 1.0 1.0 0.0 0 0 0 0 0 GO:0032225 7 regulation of synaptic transmission, dopaminergic 7 7 1 1 1 0 0 0 68 7 2472 0.82725 1.0 1.0 0.0 0 0 0 0 0 GO:0032227 7 negative regulation of synaptic transmission, dopaminergic 2 2 1 1 1 0 0 0 68 2 2477 0.94731 1.0 1.0 0.0 0 0 0 0 0 GO:0032231 6 regulation of actin filament bundle assembly 27 30 1 1 0 1 0 0 68 30 2449 0.44195 1.0 1.0 0.0 0 0 0 0 0 GO:0032233 7 positive regulation of actin filament bundle assembly 21 24 1 1 0 1 0 0 68 24 2455 0.52077 1.0 1.0 0.0 0 0 0 0 0 GO:0032309 7 icosanoid secretion 6 9 1 1 0 1 0 0 68 9 2470 0.78354 1.0 1.0 0.0 0 0 0 0 0 GO:0032310 7 prostaglandin secretion 1 2 1 1 0 1 0 0 68 2 2477 0.94731 1.0 1.0 0.0 0 0 0 0 0 GO:0032330 6 regulation of chondrocyte differentiation 9 9 1 0 0 0 0 0 68 9 2470 0.78354 1.0 1.0 0.0 0 0 0 0 0 GO:0032332 7 positive regulation of chondrocyte differentiation 6 6 1 0 0 0 0 0 68 6 2473 0.84999 1.0 1.0 0.0 0 0 0 0 0 GO:0032344 6 regulation of aldosterone metabolic process 2 2 1 0 0 0 0 0 68 2 2477 0.94731 1.0 1.0 0.0 0 0 0 0 0 GO:0032346 7 positive regulation of aldosterone metabolic process 2 2 1 0 0 0 0 0 68 2 2477 0.94731 1.0 1.0 0.0 0 0 0 0 0 GO:0032347 7 regulation of aldosterone biosynthetic process 2 2 1 0 0 0 0 0 68 2 2477 0.94731 1.0 1.0 0.0 0 0 0 0 0 GO:0032349 8 positive regulation of aldosterone biosynthetic process 2 2 1 0 0 0 0 0 68 2 2477 0.94731 1.0 1.0 0.0 0 0 0 0 0 GO:0032350 5 regulation of hormone metabolic process 23 24 1 0 0 0 0 0 68 24 2455 0.52077 1.0 1.0 0.0 0 0 0 0 0 GO:0032352 6 positive regulation of hormone metabolic process 18 19 1 0 0 0 0 0 68 19 2460 0.5969 1.0 1.0 0.0 0 0 0 0 0 GO:0032387 6 negative regulation of intracellular transport 21 23 1 1 0 1 0 0 68 23 2456 0.53518 1.0 1.0 0.0 0 0 0 0 0 GO:0032429 8 regulation of phospholipase A2 activity 3 3 1 1 0 1 0 0 68 3 2476 0.922 1.0 1.0 0.0 0 0 0 0 0 GO:0032430 9 positive regulation of phospholipase A2 activity 2 2 1 1 0 1 0 0 68 2 2477 0.94731 1.0 1.0 0.0 0 0 0 0 0 GO:0032516 8 positive regulation of phosphoprotein phosphatase activity 5 7 1 1 1 0 0 0 68 7 2472 0.82725 1.0 1.0 0.0 0 0 0 0 0 GO:0032649 6 regulation of interferon-gamma production 23 26 1 1 0 1 0 0 68 26 2453 0.49307 1.0 1.0 0.0 0 0 0 0 0 GO:0032663 6 regulation of interleukin-2 production 17 18 1 1 1 0 0 0 68 18 2461 0.61339 1.0 1.0 0.0 0 0 0 0 0 GO:0032677 6 regulation of interleukin-8 production 31 32 1 1 1 0 0 0 68 32 2447 0.41839 1.0 1.0 0.0 0 0 0 0 0 GO:0032703 7 negative regulation of interleukin-2 production 7 7 1 1 1 0 0 0 68 7 2472 0.82725 1.0 1.0 0.0 0 0 0 0 0 GO:0032715 7 negative regulation of interleukin-6 production 12 13 1 1 0 0 0 0 68 13 2466 0.70283 1.0 1.0 0.0 0 0 0 0 0 GO:0032743 7 positive regulation of interleukin-2 production 11 12 1 1 1 0 0 0 68 12 2467 0.72221 1.0 1.0 0.0 0 0 0 0 0 GO:0032763 7 regulation of mast cell cytokine production 3 3 1 1 0 1 0 0 68 3 2476 0.922 1.0 1.0 0.0 0 0 0 0 0 GO:0032764 8 negative regulation of mast cell cytokine production 1 1 1 1 0 1 0 0 68 1 2478 0.9733 1.0 1.0 0.0 0 0 0 0 0 GO:0032768 6 regulation of monooxygenase activity 20 22 1 1 1 0 0 0 68 22 2457 0.55 1.0 1.0 0.0 0 0 0 0 0 GO:0032770 7 positive regulation of monooxygenase activity 13 15 1 1 1 0 0 0 68 15 2464 0.66561 1.0 1.0 0.0 0 0 0 0 0 GO:0032771 7 regulation of monophenol monooxygenase activity 1 1 1 1 1 0 0 0 68 1 2478 0.9733 1.0 1.0 0.0 0 0 0 0 0 GO:0032773 8 positive regulation of monophenol monooxygenase activity 1 1 1 1 1 0 0 0 68 1 2478 0.9733 1.0 1.0 0.0 0 0 0 0 0 GO:0032781 7 positive regulation of ATPase activity 13 15 2 1 0 1 0 0 68 15 2464 0.66561 1.0 1.0 0.0 0 0 0 0 0 GO:0032891 6 negative regulation of organic acid transport 6 7 1 0 0 0 0 0 68 7 2472 0.82725 1.0 1.0 0.0 0 0 0 0 0 GO:0032897 6 negative regulation of viral transcription 7 7 2 2 0 1 0 0 68 7 2472 0.82725 1.0 1.0 0.0 0 0 0 0 0 GO:0032909 7 regulation of transforming growth factor beta2 production 4 4 1 1 1 0 0 0 68 4 2475 0.89735 1.0 1.0 0.0 0 0 0 0 0 GO:0032912 8 negative regulation of transforming growth factor beta2 production 1 1 1 1 1 0 0 0 68 1 2478 0.9733 1.0 1.0 0.0 0 0 0 0 0 GO:0032943 5 mononuclear cell proliferation 30 34 1 1 1 0 0 0 68 34 2445 0.39607 1.0 1.0 0.0 0 0 0 0 0 GO:0032946 8 positive regulation of mononuclear cell proliferation 48 52 1 1 1 0 0 0 68 52 2427 0.24132 1.0 0.40137 0.0 0 0 0 0 0 GO:0032967 7 positive regulation of collagen biosynthetic process 14 14 1 1 0 1 0 0 68 14 2465 0.68397 1.0 1.0 0.0 0 0 0 0 0 GO:0033004 7 negative regulation of mast cell activation 3 3 1 1 0 1 0 0 68 3 2476 0.922 1.0 1.0 0.0 0 0 0 0 0 GO:0033006 6 regulation of mast cell activation involved in immune response 16 16 1 1 0 1 0 0 68 16 2463 0.64774 1.0 1.0 0.0 0 0 0 0 0 GO:0033007 7 negative regulation of mast cell activation involved in immune response 3 3 1 1 0 1 0 0 68 3 2476 0.922 1.0 1.0 0.0 0 0 0 0 0 GO:0033014 6 tetrapyrrole biosynthetic process 8 8 1 1 1 0 0 0 68 8 2471 0.8051 1.0 1.0 0.0 0 0 0 0 0 GO:0033135 9 regulation of peptidyl-serine phosphorylation 38 46 2 2 1 0 0 0 68 46 2433 0.28477 1.0 0.63404 0.0 0 0 0 0 0 GO:0033137 10 negative regulation of peptidyl-serine phosphorylation 12 12 1 1 0 0 0 0 68 12 2467 0.72221 1.0 1.0 0.0 0 0 0 0 0 GO:0033138 10 positive regulation of peptidyl-serine phosphorylation 26 34 1 1 1 0 0 0 68 34 2445 0.39607 1.0 1.0 0.0 0 0 0 0 0 GO:0033198 5 response to ATP 13 13 2 2 1 1 0 0 68 13 2466 0.70283 1.0 1.0 0.0 0 0 0 0 0 GO:0033206 4 meiotic cytokinesis 4 4 1 1 1 0 0 0 68 4 2475 0.89735 1.0 1.0 0.0 0 0 0 0 0 GO:0033552 6 response to vitamin B3 2 2 1 1 0 1 0 0 68 2 2477 0.94731 1.0 1.0 0.0 0 0 0 0 0 GO:0033555 3 multicellular organismal response to stress 16 17 1 1 0 0 0 0 68 17 2462 0.63033 1.0 1.0 0.0 0 0 0 0 0 GO:0033574 5 response to testosterone 28 31 2 2 0 1 0 0 68 31 2448 0.43001 1.0 1.0 0.0 0 0 0 0 0 GO:0033962 7 cytoplasmic mRNA processing body assembly 3 3 1 1 1 0 0 0 68 3 2476 0.922 1.0 1.0 0.0 0 0 0 0 0 GO:0034101 6 erythrocyte homeostasis 4 4 1 1 0 1 0 0 68 4 2475 0.89735 1.0 1.0 0.0 0 0 0 0 0 GO:0034103 5 regulation of tissue remodeling 28 28 1 1 0 0 0 0 68 28 2451 0.46682 1.0 1.0 0.0 0 0 0 0 0 GO:0034105 6 positive regulation of tissue remodeling 16 16 1 1 0 0 0 0 68 16 2463 0.64774 1.0 1.0 0.0 0 0 0 0 0 GO:0034113 5 heterotypic cell-cell adhesion 7 7 1 1 1 0 0 0 68 7 2472 0.82725 1.0 1.0 0.0 0 0 0 0 0 GO:0034138 7 toll-like receptor 3 signaling pathway 3 5 1 1 0 1 0 0 68 5 2474 0.87336 1.0 1.0 0.0 0 0 0 0 0 GO:0034260 5 negative regulation of GTPase activity 5 5 1 1 1 0 0 0 68 5 2474 0.87336 1.0 1.0 0.0 0 0 0 0 0 GO:0034332 7 adherens junction organization 9 9 1 1 1 0 0 0 68 9 2470 0.78354 1.0 1.0 0.0 0 0 0 0 0 GO:0034340 6 response to type I interferon 4 4 1 1 0 1 0 0 68 4 2475 0.89735 1.0 1.0 0.0 0 0 0 0 0 GO:0034350 8 regulation of glial cell apoptotic process 5 5 1 1 0 1 0 0 68 5 2474 0.87336 1.0 1.0 0.0 0 0 0 0 0 GO:0034351 9 negative regulation of glial cell apoptotic process 4 4 1 1 0 1 0 0 68 4 2475 0.89735 1.0 1.0 0.0 0 0 0 0 0 GO:0034391 9 regulation of smooth muscle cell apoptotic process 11 13 1 1 0 1 0 0 68 13 2466 0.70283 1.0 1.0 0.0 0 0 0 0 0 GO:0034392 10 negative regulation of smooth muscle cell apoptotic process 6 8 1 1 0 1 0 0 68 8 2471 0.8051 1.0 1.0 0.0 0 0 0 0 0 GO:0034395 9 regulation of transcription from RNA polymerase II promoter in response to iron 2 2 1 1 0 1 0 0 68 2 2477 0.94731 1.0 1.0 0.0 0 0 0 0 0 GO:0034401 6 chromatin organization involved in regulation of transcription 19 22 1 1 1 0 0 0 68 22 2457 0.55 1.0 1.0 0.0 0 0 0 0 0 GO:0034405 4 response to fluid shear stress 18 20 3 3 1 1 0 0 68 20 2459 0.58084 1.0 1.0 0.0 0 0 0 0 0 GO:0034414 9 tRNA 3'-trailer cleavage, endonucleolytic 1 1 1 1 0 1 0 0 68 1 2478 0.9733 1.0 1.0 0.0 0 0 0 0 0 GO:0034418 5 urate biosynthetic process 2 2 1 1 0 0 0 0 68 2 2477 0.94731 1.0 1.0 0.0 0 0 0 0 0 GO:0034470 8 ncRNA processing 32 40 1 1 1 0 0 0 68 40 2439 0.3359 1.0 0.62555 0.0 0 0 0 0 0 GO:0034587 8 piRNA metabolic process 1 1 1 1 0 1 0 0 68 1 2478 0.9733 1.0 1.0 0.0 0 0 0 0 0 GO:0034655 5 nucleobase-containing compound catabolic process 33 39 1 1 1 0 0 0 68 39 2440 0.34527 1.0 0.62489 0.0 0 0 0 0 0 GO:0034660 7 ncRNA metabolic process 43 51 2 2 1 1 0 0 68 51 2428 0.24807 1.0 0.64581 0.0 0 0 0 0 0 GO:0034694 5 response to prostaglandin 15 16 1 1 0 0 0 0 68 16 2463 0.64774 1.0 1.0 0.0 0 0 0 0 0 GO:0034695 6 response to prostaglandin E 12 13 1 1 0 0 0 0 68 13 2466 0.70283 1.0 1.0 0.0 0 0 0 0 0 GO:0034755 8 iron ion transmembrane transport 4 4 1 1 0 1 0 0 68 4 2475 0.89735 1.0 1.0 0.0 0 0 0 0 0 GO:0035019 4 somatic stem cell population maintenance 9 10 1 1 0 0 0 0 68 10 2469 0.76254 1.0 1.0 0.0 0 0 0 0 0 GO:0035026 6 leading edge cell differentiation 2 2 1 1 0 0 0 0 68 2 2477 0.94731 1.0 1.0 0.0 0 0 0 0 0 GO:0035148 4 tube formation 35 37 1 1 0 0 0 0 68 37 2442 0.36477 1.0 0.62433 0.0 0 0 0 0 0 GO:0035188 4 hatching 6 6 1 1 1 0 0 0 68 6 2473 0.84999 1.0 1.0 0.0 0 0 0 0 0 GO:0035235 7 ionotropic glutamate receptor signaling pathway 13 13 1 1 0 0 0 0 68 13 2466 0.70283 1.0 1.0 0.0 0 0 0 0 0 GO:0035249 8 synaptic transmission, glutamatergic 10 10 1 1 0 0 0 0 68 10 2469 0.76254 1.0 1.0 0.0 0 0 0 0 0 GO:0035303 8 regulation of dephosphorylation 40 45 2 2 2 0 0 0 68 45 2434 0.29272 1.0 0.63214 0.0 0 0 0 0 0 GO:0035304 8 regulation of protein dephosphorylation 25 28 1 1 1 0 0 0 68 28 2451 0.46682 1.0 1.0 0.0 0 0 0 0 0 GO:0035305 9 negative regulation of dephosphorylation 15 18 1 1 1 0 0 0 68 18 2461 0.61339 1.0 1.0 0.0 0 0 0 0 0 GO:0035306 9 positive regulation of dephosphorylation 19 21 1 1 1 0 0 0 68 21 2458 0.56521 1.0 1.0 0.0 0 0 0 0 0 GO:0035307 9 positive regulation of protein dephosphorylation 11 13 1 1 1 0 0 0 68 13 2466 0.70283 1.0 1.0 0.0 0 0 0 0 0 GO:0035335 8 peptidyl-tyrosine dephosphorylation 16 20 4 4 2 1 0 0 68 20 2459 0.58084 1.0 1.0 0.0 0 0 0 0 0 GO:0035418 6 protein localization to synapse 9 9 1 1 1 0 0 0 68 9 2470 0.78354 1.0 1.0 0.0 0 0 0 0 0 GO:0035425 4 autocrine signaling 4 4 1 1 1 0 0 0 68 4 2475 0.89735 1.0 1.0 0.0 0 0 0 0 0 GO:0035455 6 response to interferon-alpha 11 11 2 2 0 1 0 0 68 11 2468 0.74211 1.0 1.0 0.0 0 0 0 0 0 GO:0035456 6 response to interferon-beta 10 12 1 1 0 0 0 0 68 12 2467 0.72221 1.0 1.0 0.0 0 0 0 0 0 GO:0035457 7 cellular response to interferon-alpha 7 7 1 1 0 1 0 0 68 7 2472 0.82725 1.0 1.0 0.0 0 0 0 0 0 GO:0035584 8 calcium-mediated signaling using intracellular calcium source 6 6 1 1 1 0 0 0 68 6 2473 0.84999 1.0 1.0 0.0 0 0 0 0 0 GO:0035684 8 helper T cell extravasation 1 1 1 1 0 1 0 0 68 1 2478 0.9733 1.0 1.0 0.0 0 0 0 0 0 GO:0035791 9 platelet-derived growth factor receptor-beta signaling pathway 3 4 1 1 0 1 0 0 68 4 2475 0.89735 1.0 1.0 0.0 0 0 0 0 0 GO:0035793 9 positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway 2 2 1 1 0 1 0 0 68 2 2477 0.94731 1.0 1.0 0.0 0 0 0 0 0 GO:0035910 4 ascending aorta morphogenesis 2 2 1 1 0 0 0 0 68 2 2477 0.94731 1.0 1.0 0.0 0 0 0 0 0 GO:0035924 7 cellular response to vascular endothelial growth factor stimulus 17 17 1 1 0 0 0 0 68 17 2462 0.63033 1.0 1.0 0.0 0 0 0 0 0 GO:0035970 8 peptidyl-threonine dephosphorylation 3 4 1 1 1 0 0 0 68 4 2475 0.89735 1.0 1.0 0.0 0 0 0 0 0 GO:0035994 5 response to muscle stretch 14 14 1 1 0 0 0 0 68 14 2465 0.68397 1.0 1.0 0.0 0 0 0 0 0 GO:0035999 6 tetrahydrofolate interconversion 3 3 1 1 1 0 0 0 68 3 2476 0.922 1.0 1.0 0.0 0 0 0 0 0 GO:0036005 6 response to macrophage colony-stimulating factor 3 3 1 1 0 1 0 0 68 3 2476 0.922 1.0 1.0 0.0 0 0 0 0 0 GO:0036006 7 cellular response to macrophage colony-stimulating factor stimulus 3 3 1 1 0 1 0 0 68 3 2476 0.922 1.0 1.0 0.0 0 0 0 0 0 GO:0036072 4 direct ossification 3 3 2 2 0 1 0 0 68 3 2476 0.922 1.0 1.0 0.0 0 0 0 0 0 GO:0036075 4 replacement ossification 7 7 1 0 0 0 0 0 68 7 2472 0.82725 1.0 1.0 0.0 0 0 0 0 0 GO:0036092 8 phosphatidylinositol-3-phosphate biosynthetic process 6 6 1 1 1 0 0 0 68 6 2473 0.84999 1.0 1.0 0.0 0 0 0 0 0 GO:0036270 5 response to diuretic 17 17 1 1 0 0 0 0 68 17 2462 0.63033 1.0 1.0 0.0 0 0 0 0 0 GO:0038093 7 Fc receptor signaling pathway 6 7 1 1 0 0 0 0 68 7 2472 0.82725 1.0 1.0 0.0 0 0 0 0 0 GO:0038094 8 Fc-gamma receptor signaling pathway 3 4 1 1 0 0 0 0 68 4 2475 0.89735 1.0 1.0 0.0 0 0 0 0 0 GO:0038166 6 angiotensin-activated signaling pathway 3 3 1 1 0 1 0 0 68 3 2476 0.922 1.0 1.0 0.0 0 0 0 0 0 GO:0038183 5 bile acid signaling pathway 14 14 2 2 1 1 0 0 68 14 2465 0.68397 1.0 1.0 0.0 0 0 0 0 0 GO:0040001 7 establishment of mitotic spindle localization 10 10 1 1 1 0 0 0 68 10 2469 0.76254 1.0 1.0 0.0 0 0 0 0 0 GO:0040029 7 regulation of gene expression, epigenetic 21 26 1 1 1 0 0 0 68 26 2453 0.49307 1.0 1.0 0.0 0 0 0 0 0 GO:0040038 4 polar body extrusion after meiotic divisions 4 4 1 1 1 0 0 0 68 4 2475 0.89735 1.0 1.0 0.0 0 0 0 0 0 GO:0042035 6 regulation of cytokine biosynthetic process 40 43 1 1 1 0 0 0 68 43 2436 0.3093 1.0 0.6289 0.0 0 0 0 0 0 GO:0042036 7 negative regulation of cytokine biosynthetic process 9 9 1 1 1 0 0 0 68 9 2470 0.78354 1.0 1.0 0.0 0 0 0 0 0 GO:0042098 6 T cell proliferation 19 21 1 1 1 0 0 0 68 21 2458 0.56521 1.0 1.0 0.0 0 0 0 0 0 GO:0042100 6 B cell proliferation 12 13 1 1 1 0 0 0 68 13 2466 0.70283 1.0 1.0 0.0 0 0 0 0 0 GO:0042102 9 positive regulation of T cell proliferation 34 36 1 1 1 0 0 0 68 36 2443 0.37492 1.0 0.62447 0.0 0 0 0 0 0 GO:0042108 7 positive regulation of cytokine biosynthetic process 31 34 1 1 1 0 0 0 68 34 2445 0.39607 1.0 1.0 0.0 0 0 0 0 0 GO:0042110 5 T cell activation 79 84 2 2 1 0 0 0 68 84 2395 0.099111 1.0 0.17032 0.0 0 0 0 0 0 GO:0042113 5 B cell activation 34 36 1 1 1 0 0 0 68 36 2443 0.37492 1.0 0.62447 0.0 0 0 0 0 0 GO:0042133 4 neurotransmitter metabolic process 31 35 1 1 0 1 0 0 68 35 2444 0.38535 1.0 1.0 0.0 0 0 0 0 0 GO:0042180 4 cellular ketone metabolic process 23 27 1 1 0 1 0 0 68 27 2452 0.47977 1.0 1.0 0.0 0 0 0 0 0 GO:0042303 3 molting cycle 1 1 1 1 1 0 0 0 68 1 2478 0.9733 1.0 1.0 0.0 0 0 0 0 0 GO:0042304 7 regulation of fatty acid biosynthetic process 23 24 1 1 1 0 0 0 68 24 2455 0.52077 1.0 1.0 0.0 0 0 0 0 0 GO:0042310 8 vasoconstriction 6 7 1 1 0 1 0 0 68 7 2472 0.82725 1.0 1.0 0.0 0 0 0 0 0 GO:0042403 5 thyroid hormone metabolic process 7 8 1 1 0 0 0 0 68 8 2471 0.8051 1.0 1.0 0.0 0 0 0 0 0 GO:0042416 6 dopamine biosynthetic process 6 6 1 1 0 1 0 0 68 6 2473 0.84999 1.0 1.0 0.0 0 0 0 0 0 GO:0042417 5 dopamine metabolic process 10 12 1 1 0 1 0 0 68 12 2467 0.72221 1.0 1.0 0.0 0 0 0 0 0 GO:0042423 7 catecholamine biosynthetic process 8 8 1 1 0 1 0 0 68 8 2471 0.8051 1.0 1.0 0.0 0 0 0 0 0 GO:0042428 5 serotonin metabolic process 5 6 1 1 0 1 0 0 68 6 2473 0.84999 1.0 1.0 0.0 0 0 0 0 0 GO:0042430 5 indole-containing compound metabolic process 11 12 1 1 0 1 0 0 68 12 2467 0.72221 1.0 1.0 0.0 0 0 0 0 0 GO:0042447 5 hormone catabolic process 7 11 2 2 0 1 0 0 68 11 2468 0.74211 1.0 1.0 0.0 0 0 0 0 0 GO:0042448 7 progesterone metabolic process 5 7 1 1 0 1 0 0 68 7 2472 0.82725 1.0 1.0 0.0 0 0 0 0 0 GO:0042465 4 kinesis 2 2 1 1 0 1 0 0 68 2 2477 0.94731 1.0 1.0 0.0 0 0 0 0 0 GO:0042466 5 chemokinesis 2 2 1 1 0 1 0 0 68 2 2477 0.94731 1.0 1.0 0.0 0 0 0 0 0 GO:0042537 5 benzene-containing compound metabolic process 17 24 1 1 0 0 0 0 68 24 2455 0.52077 1.0 1.0 0.0 0 0 0 0 0 GO:0042541 6 hemoglobin biosynthetic process 5 5 1 1 1 0 0 0 68 5 2474 0.87336 1.0 1.0 0.0 0 0 0 0 0 GO:0042558 5 pteridine-containing compound metabolic process 8 10 1 1 1 0 0 0 68 10 2469 0.76254 1.0 1.0 0.0 0 0 0 0 0 GO:0042590 6 antigen processing and presentation of exogenous peptide antigen via MHC class I 5 7 1 1 0 0 0 0 68 7 2472 0.82725 1.0 1.0 0.0 0 0 0 0 0 GO:0042596 4 fear response 10 11 1 1 0 0 0 0 68 11 2468 0.74211 1.0 1.0 0.0 0 0 0 0 0 GO:0042633 4 hair cycle 1 1 1 1 1 0 0 0 68 1 2478 0.9733 1.0 1.0 0.0 0 0 0 0 0 GO:0042636 6 negative regulation of hair cycle 2 2 1 1 1 0 0 0 68 2 2477 0.94731 1.0 1.0 0.0 0 0 0 0 0 GO:0042744 6 hydrogen peroxide catabolic process 11 11 2 2 1 0 0 0 68 11 2468 0.74211 1.0 1.0 0.0 0 0 0 0 0 GO:0042747 6 circadian sleep/wake cycle, REM sleep 3 3 1 1 0 1 0 0 68 3 2476 0.922 1.0 1.0 0.0 0 0 0 0 0 GO:0042756 4 drinking behavior 3 4 1 1 0 1 0 0 68 4 2475 0.89735 1.0 1.0 0.0 0 0 0 0 0 GO:0042769 5 DNA damage response, detection of DNA damage 3 3 1 1 0 0 0 0 68 3 2476 0.922 1.0 1.0 0.0 0 0 0 0 0 GO:0042770 6 signal transduction in response to DNA damage 22 24 2 2 1 0 0 0 68 24 2455 0.52077 1.0 1.0 0.0 0 0 0 0 0 GO:0042779 8 tRNA 3'-trailer cleavage 1 1 1 1 0 1 0 0 68 1 2478 0.9733 1.0 1.0 0.0 0 0 0 0 0 GO:0042976 10 activation of Janus kinase activity 6 6 1 1 0 1 0 0 68 6 2473 0.84999 1.0 1.0 0.0 0 0 0 0 0 GO:0042982 5 amyloid precursor protein metabolic process 5 5 1 1 1 0 0 0 68 5 2474 0.87336 1.0 1.0 0.0 0 0 0 0 0 GO:0043114 5 regulation of vascular permeability 12 12 1 0 0 0 0 0 68 12 2467 0.72221 1.0 1.0 0.0 0 0 0 0 0 GO:0043117 6 positive regulation of vascular permeability 8 8 1 0 0 0 0 0 68 8 2471 0.8051 1.0 1.0 0.0 0 0 0 0 0 GO:0043300 6 regulation of leukocyte degranulation 20 20 1 1 0 1 0 0 68 20 2459 0.58084 1.0 1.0 0.0 0 0 0 0 0 GO:0043301 7 negative regulation of leukocyte degranulation 4 4 1 1 0 1 0 0 68 4 2475 0.89735 1.0 1.0 0.0 0 0 0 0 0 GO:0043304 7 regulation of mast cell degranulation 15 15 1 1 0 1 0 0 68 15 2464 0.66561 1.0 1.0 0.0 0 0 0 0 0 GO:0043305 7 negative regulation of mast cell degranulation 2 2 1 1 0 1 0 0 68 2 2477 0.94731 1.0 1.0 0.0 0 0 0 0 0 GO:0043330 6 response to exogenous dsRNA 12 13 1 1 0 1 0 0 68 13 2466 0.70283 1.0 1.0 0.0 0 0 0 0 0 GO:0043331 5 response to dsRNA 17 18 1 1 0 1 0 0 68 18 2461 0.61339 1.0 1.0 0.0 0 0 0 0 0 GO:0043368 4 positive T cell selection 4 5 1 1 1 0 0 0 68 5 2474 0.87336 1.0 1.0 0.0 0 0 0 0 0 GO:0043383 4 negative T cell selection 5 5 1 1 1 0 0 0 68 5 2474 0.87336 1.0 1.0 0.0 0 0 0 0 0 GO:0043392 6 negative regulation of DNA binding 10 10 2 2 0 1 0 0 68 10 2469 0.76254 1.0 1.0 0.0 0 0 0 0 0 GO:0043406 9 positive regulation of MAP kinase activity 68 75 3 3 1 1 0 0 68 75 2404 0.12745 1.0 0.26549 0.0 0 0 0 0 0 GO:0043433 8 negative regulation of DNA-binding transcription factor activity 32 34 1 1 0 1 0 0 68 34 2445 0.39607 1.0 1.0 0.0 0 0 0 0 0 GO:0043455 5 regulation of secondary metabolic process 6 6 1 1 1 0 0 0 68 6 2473 0.84999 1.0 1.0 0.0 0 0 0 0 0 GO:0043462 6 regulation of ATPase activity 20 22 2 1 0 1 0 0 68 22 2457 0.55 1.0 1.0 0.0 0 0 0 0 0 GO:0043484 7 regulation of RNA splicing 21 23 1 1 1 0 0 0 68 23 2456 0.53518 1.0 1.0 0.0 0 0 0 0 0 GO:0043487 5 regulation of RNA stability 15 16 1 1 1 0 0 0 68 16 2463 0.64774 1.0 1.0 0.0 0 0 0 0 0 GO:0043488 6 regulation of mRNA stability 15 16 1 1 1 0 0 0 68 16 2463 0.64774 1.0 1.0 0.0 0 0 0 0 0 GO:0043489 6 RNA stabilization 10 10 1 1 1 0 0 0 68 10 2469 0.76254 1.0 1.0 0.0 0 0 0 0 0 GO:0043491 6 protein kinase B signaling 19 20 2 2 1 1 0 0 68 20 2459 0.58084 1.0 1.0 0.0 0 0 0 0 0 GO:0043502 5 regulation of muscle adaptation 33 33 2 1 0 1 0 0 68 33 2446 0.40708 1.0 1.0 0.0 0 0 0 0 0 GO:0043535 7 regulation of blood vessel endothelial cell migration 35 37 2 2 1 1 0 0 68 37 2442 0.36477 1.0 0.62433 0.0 0 0 0 0 0 GO:0043536 8 positive regulation of blood vessel endothelial cell migration 22 23 2 2 1 1 0 0 68 23 2456 0.53518 1.0 1.0 0.0 0 0 0 0 0 GO:0043542 7 endothelial cell migration 25 26 1 1 1 0 0 0 68 26 2453 0.49307 1.0 1.0 0.0 0 0 0 0 0 GO:0043567 6 regulation of insulin-like growth factor receptor signaling pathway 8 8 1 1 1 0 0 0 68 8 2471 0.8051 1.0 1.0 0.0 0 0 0 0 0 GO:0043568 7 positive regulation of insulin-like growth factor receptor signaling pathway 5 5 1 1 1 0 0 0 68 5 2474 0.87336 1.0 1.0 0.0 0 0 0 0 0 GO:0043615 6 astrocyte cell migration 2 2 1 1 0 1 0 0 68 2 2477 0.94731 1.0 1.0 0.0 0 0 0 0 0 GO:0043618 8 regulation of transcription from RNA polymerase II promoter in response to stress 23 25 3 3 0 1 0 0 68 25 2454 0.50673 1.0 1.0 0.0 0 0 0 0 0 GO:0043619 9 regulation of transcription from RNA polymerase II promoter in response to oxidative stress 6 6 1 1 0 1 0 0 68 6 2473 0.84999 1.0 1.0 0.0 0 0 0 0 0 GO:0043620 7 regulation of DNA-templated transcription in response to stress 24 26 3 3 0 1 0 0 68 26 2453 0.49307 1.0 1.0 0.0 0 0 0 0 0 GO:0043666 7 regulation of phosphoprotein phosphatase activity 19 22 1 1 1 0 0 0 68 22 2457 0.55 1.0 1.0 0.0 0 0 0 0 0 GO:0043922 6 negative regulation by host of viral transcription 5 5 2 2 0 1 0 0 68 5 2474 0.87336 1.0 1.0 0.0 0 0 0 0 0 GO:0043923 6 positive regulation by host of viral transcription 6 6 2 2 1 0 0 0 68 6 2473 0.84999 1.0 1.0 0.0 0 0 0 0 0 GO:0043949 7 regulation of cAMP-mediated signaling 11 11 1 0 0 0 0 0 68 11 2468 0.74211 1.0 1.0 0.0 0 0 0 0 0 GO:0043951 8 negative regulation of cAMP-mediated signaling 3 3 1 0 0 0 0 0 68 3 2476 0.922 1.0 1.0 0.0 0 0 0 0 0 GO:0043967 9 histone H4 acetylation 7 7 1 1 0 0 0 0 68 7 2472 0.82725 1.0 1.0 0.0 0 0 0 0 0 GO:0044060 6 regulation of endocrine process 18 18 2 1 0 1 0 0 68 18 2461 0.61339 1.0 1.0 0.0 0 0 0 0 0 GO:0044331 5 cell-cell adhesion mediated by cadherin 4 4 1 1 1 0 0 0 68 4 2475 0.89735 1.0 1.0 0.0 0 0 0 0 0 GO:0044406 3 adhesion of symbiont to host 7 7 1 1 0 0 0 0 68 7 2472 0.82725 1.0 1.0 0.0 0 0 0 0 0 GO:0044782 6 cilium organization 18 19 2 2 0 2 0 0 68 19 2460 0.5969 1.0 1.0 0.0 0 0 0 0 0 GO:0044855 7 plasma membrane raft distribution 1 1 1 1 1 0 0 0 68 1 2478 0.9733 1.0 1.0 0.0 0 0 0 0 0 GO:0044856 6 plasma membrane raft localization 1 1 1 1 1 0 0 0 68 1 2478 0.9733 1.0 1.0 0.0 0 0 0 0 0 GO:0045058 3 T cell selection 11 12 1 1 1 0 0 0 68 12 2467 0.72221 1.0 1.0 0.0 0 0 0 0 0 GO:0045059 5 positive thymic T cell selection 4 5 1 1 1 0 0 0 68 5 2474 0.87336 1.0 1.0 0.0 0 0 0 0 0 GO:0045060 5 negative thymic T cell selection 5 5 1 1 1 0 0 0 68 5 2474 0.87336 1.0 1.0 0.0 0 0 0 0 0 GO:0045061 4 thymic T cell selection 8 9 1 1 1 0 0 0 68 9 2470 0.78354 1.0 1.0 0.0 0 0 0 0 0 GO:0045076 7 regulation of interleukin-2 biosynthetic process 7 7 1 1 1 0 0 0 68 7 2472 0.82725 1.0 1.0 0.0 0 0 0 0 0 GO:0045085 8 negative regulation of interleukin-2 biosynthetic process 2 2 1 1 1 0 0 0 68 2 2477 0.94731 1.0 1.0 0.0 0 0 0 0 0 GO:0045086 8 positive regulation of interleukin-2 biosynthetic process 6 6 1 1 1 0 0 0 68 6 2473 0.84999 1.0 1.0 0.0 0 0 0 0 0 GO:0045089 7 positive regulation of innate immune response 24 24 1 1 0 1 0 0 68 24 2455 0.52077 1.0 1.0 0.0 0 0 0 0 0 GO:0045103 3 intermediate filament-based process 10 10 1 0 0 1 0 0 68 10 2469 0.76254 1.0 1.0 0.0 0 0 0 0 0 GO:0045104 5 intermediate filament cytoskeleton organization 10 10 1 0 0 1 0 0 68 10 2469 0.76254 1.0 1.0 0.0 0 0 0 0 0 GO:0045109 5 intermediate filament organization 5 5 1 0 0 1 0 0 68 5 2474 0.87336 1.0 1.0 0.0 0 0 0 0 0 GO:0045123 6 cellular extravasation 6 7 1 1 0 1 0 0 68 7 2472 0.82725 1.0 1.0 0.0 0 0 0 0 0 GO:0045124 5 regulation of bone resorption 18 18 1 1 0 0 0 0 68 18 2461 0.61339 1.0 1.0 0.0 0 0 0 0 0 GO:0045143 5 homologous chromosome segregation 4 4 1 1 1 0 0 0 68 4 2475 0.89735 1.0 1.0 0.0 0 0 0 0 0 GO:0045191 7 regulation of isotype switching 6 6 1 1 1 0 0 0 68 6 2473 0.84999 1.0 1.0 0.0 0 0 0 0 0 GO:0045444 5 fat cell differentiation 31 34 3 2 1 1 0 0 68 34 2445 0.39607 1.0 1.0 0.0 0 0 0 0 0 GO:0045453 7 bone resorption 12 12 1 1 0 0 0 0 68 12 2467 0.72221 1.0 1.0 0.0 0 0 0 0 0 GO:0045582 9 positive regulation of T cell differentiation 34 35 2 2 1 0 0 0 68 35 2444 0.38535 1.0 1.0 0.0 0 0 0 0 0 GO:0045586 9 regulation of gamma-delta T cell differentiation 7 7 2 2 1 0 0 0 68 7 2472 0.82725 1.0 1.0 0.0 0 0 0 0 0 GO:0045588 10 positive regulation of gamma-delta T cell differentiation 7 7 2 2 1 0 0 0 68 7 2472 0.82725 1.0 1.0 0.0 0 0 0 0 0 GO:0045600 7 positive regulation of fat cell differentiation 16 17 2 2 2 0 0 0 68 17 2462 0.63033 1.0 1.0 0.0 0 0 0 0 0 GO:0045601 7 regulation of endothelial cell differentiation 18 19 1 0 0 0 0 0 68 19 2460 0.5969 1.0 1.0 0.0 0 0 0 0 0 GO:0045603 8 positive regulation of endothelial cell differentiation 8 8 1 0 0 0 0 0 68 8 2471 0.8051 1.0 1.0 0.0 0 0 0 0 0 GO:0045621 8 positive regulation of lymphocyte differentiation 36 37 2 2 1 0 0 0 68 37 2442 0.36477 1.0 0.62433 0.0 0 0 0 0 0 GO:0045637 6 regulation of myeloid cell differentiation 70 75 2 2 0 1 0 0 68 75 2404 0.12745 1.0 0.26549 0.0 0 0 0 0 0 GO:0045639 7 positive regulation of myeloid cell differentiation 40 45 2 2 0 1 0 0 68 45 2434 0.29272 1.0 0.63214 0.0 0 0 0 0 0 GO:0045646 5 regulation of erythrocyte differentiation 19 21 1 1 0 1 0 0 68 21 2458 0.56521 1.0 1.0 0.0 0 0 0 0 0 GO:0045648 6 positive regulation of erythrocyte differentiation 15 16 1 1 0 1 0 0 68 16 2463 0.64774 1.0 1.0 0.0 0 0 0 0 0 GO:0045655 8 regulation of monocyte differentiation 7 7 1 1 0 0 0 0 68 7 2472 0.82725 1.0 1.0 0.0 0 0 0 0 0 GO:0045657 9 positive regulation of monocyte differentiation 4 4 1 1 0 0 0 0 68 4 2475 0.89735 1.0 1.0 0.0 0 0 0 0 0 GO:0045668 7 negative regulation of osteoblast differentiation 7 8 1 1 1 0 0 0 68 8 2471 0.8051 1.0 1.0 0.0 0 0 0 0 0 GO:0045683 6 negative regulation of epidermis development 6 6 1 1 1 0 0 0 68 6 2473 0.84999 1.0 1.0 0.0 0 0 0 0 0 GO:0045723 8 positive regulation of fatty acid biosynthetic process 13 14 1 1 1 0 0 0 68 14 2465 0.68397 1.0 1.0 0.0 0 0 0 0 0 GO:0045727 8 positive regulation of translation 24 28 1 1 0 0 0 0 68 28 2451 0.46682 1.0 1.0 0.0 0 0 0 0 0 GO:0045736 9 negative regulation of cyclin-dependent protein serine/threonine kinase activity 8 8 1 1 1 0 0 0 68 8 2471 0.8051 1.0 1.0 0.0 0 0 0 0 0 GO:0045740 8 positive regulation of DNA replication 17 19 1 1 0 0 0 0 68 19 2460 0.5969 1.0 1.0 0.0 0 0 0 0 0 GO:0045744 7 negative regulation of G protein-coupled receptor signaling pathway 10 10 1 0 0 0 0 0 68 10 2469 0.76254 1.0 1.0 0.0 0 0 0 0 0 GO:0045777 5 positive regulation of blood pressure 13 15 1 1 0 1 0 0 68 15 2464 0.66561 1.0 1.0 0.0 0 0 0 0 0 GO:0045780 6 positive regulation of bone resorption 11 11 1 1 0 0 0 0 68 11 2468 0.74211 1.0 1.0 0.0 0 0 0 0 0 GO:0045814 8 negative regulation of gene expression, epigenetic 6 9 1 1 1 0 0 0 68 9 2470 0.78354 1.0 1.0 0.0 0 0 0 0 0 GO:0045823 7 positive regulation of heart contraction 9 10 1 0 0 0 0 0 68 10 2469 0.76254 1.0 1.0 0.0 0 0 0 0 0 GO:0045830 8 positive regulation of isotype switching 6 6 1 1 1 0 0 0 68 6 2473 0.84999 1.0 1.0 0.0 0 0 0 0 0 GO:0045833 6 negative regulation of lipid metabolic process 31 34 1 1 0 1 0 0 68 34 2445 0.39607 1.0 1.0 0.0 0 0 0 0 0 GO:0045843 7 negative regulation of striated muscle tissue development 21 21 1 0 0 0 0 0 68 21 2458 0.56521 1.0 1.0 0.0 0 0 0 0 0 GO:0045906 7 negative regulation of vasoconstriction 8 8 2 2 1 1 0 0 68 8 2471 0.8051 1.0 1.0 0.0 0 0 0 0 0 GO:0045911 8 positive regulation of DNA recombination 8 8 1 1 1 0 0 0 68 8 2471 0.8051 1.0 1.0 0.0 0 0 0 0 0 GO:0045920 7 negative regulation of exocytosis 8 8 1 1 0 1 0 0 68 8 2471 0.8051 1.0 1.0 0.0 0 0 0 0 0 GO:0045933 6 positive regulation of muscle contraction 15 16 2 1 1 0 0 0 68 16 2463 0.64774 1.0 1.0 0.0 0 0 0 0 0 GO:0045987 7 positive regulation of smooth muscle contraction 12 12 1 1 1 0 0 0 68 12 2467 0.72221 1.0 1.0 0.0 0 0 0 0 0 GO:0045989 7 positive regulation of striated muscle contraction 3 4 1 0 0 0 0 0 68 4 2475 0.89735 1.0 1.0 0.0 0 0 0 0 0 GO:0045995 6 regulation of embryonic development 34 36 1 1 1 0 0 0 68 36 2443 0.37492 1.0 0.62447 0.0 0 0 0 0 0 GO:0046148 4 pigment biosynthetic process 8 10 1 1 1 0 0 0 68 10 2469 0.76254 1.0 1.0 0.0 0 0 0 0 0 GO:0046189 6 phenol-containing compound biosynthetic process 8 8 1 1 0 1 0 0 68 8 2471 0.8051 1.0 1.0 0.0 0 0 0 0 0 GO:0046415 5 urate metabolic process 6 6 1 1 0 0 0 0 68 6 2473 0.84999 1.0 1.0 0.0 0 0 0 0 0 GO:0046457 7 prostanoid biosynthetic process 5 7 1 1 1 0 0 0 68 7 2472 0.82725 1.0 1.0 0.0 0 0 0 0 0 GO:0046488 7 phosphatidylinositol metabolic process 26 28 1 1 1 0 0 0 68 28 2451 0.46682 1.0 1.0 0.0 0 0 0 0 0 GO:0046501 6 protoporphyrinogen IX metabolic process 4 4 1 1 1 0 0 0 68 4 2475 0.89735 1.0 1.0 0.0 0 0 0 0 0 GO:0046596 6 regulation of viral entry into host cell 10 10 1 1 0 0 0 0 68 10 2469 0.76254 1.0 1.0 0.0 0 0 0 0 0 GO:0046597 7 negative regulation of viral entry into host cell 5 5 1 1 0 0 0 0 68 5 2474 0.87336 1.0 1.0 0.0 0 0 0 0 0 GO:0046620 5 regulation of organ growth 36 37 2 1 0 0 0 0 68 37 2442 0.36477 1.0 0.62433 0.0 0 0 0 0 0 GO:0046621 6 negative regulation of organ growth 14 14 1 0 0 0 0 0 68 14 2465 0.68397 1.0 1.0 0.0 0 0 0 0 0 GO:0046634 8 regulation of alpha-beta T cell activation 30 31 1 1 1 0 0 0 68 31 2448 0.43001 1.0 1.0 0.0 0 0 0 0 0 GO:0046635 9 positive regulation of alpha-beta T cell activation 23 24 1 1 1 0 0 0 68 24 2455 0.52077 1.0 1.0 0.0 0 0 0 0 0 GO:0046640 9 regulation of alpha-beta T cell proliferation 12 13 1 1 1 0 0 0 68 13 2466 0.70283 1.0 1.0 0.0 0 0 0 0 0 GO:0046641 10 positive regulation of alpha-beta T cell proliferation 9 10 1 1 1 0 0 0 68 10 2469 0.76254 1.0 1.0 0.0 0 0 0 0 0 GO:0046643 8 regulation of gamma-delta T cell activation 7 7 2 2 1 0 0 0 68 7 2472 0.82725 1.0 1.0 0.0 0 0 0 0 0 GO:0046645 9 positive regulation of gamma-delta T cell activation 7 7 2 2 1 0 0 0 68 7 2472 0.82725 1.0 1.0 0.0 0 0 0 0 0 GO:0046649 4 lymphocyte activation 104 112 2 2 1 0 0 0 68 112 2367 0.045057 1.0 0.072847 0.0 0 0 0 0 0 GO:0046651 5 lymphocyte proliferation 29 33 1 1 1 0 0 0 68 33 2446 0.40708 1.0 1.0 0.0 0 0 0 0 0 GO:0046653 6 tetrahydrofolate metabolic process 5 6 1 1 1 0 0 0 68 6 2473 0.84999 1.0 1.0 0.0 0 0 0 0 0 GO:0046661 5 male sex differentiation 4 4 1 1 0 1 0 0 68 4 2475 0.89735 1.0 1.0 0.0 0 0 0 0 0 GO:0046689 6 response to mercury ion 10 11 1 1 0 0 0 0 68 11 2468 0.74211 1.0 1.0 0.0 0 0 0 0 0 GO:0046717 6 acid secretion 18 21 1 1 0 1 0 0 68 21 2458 0.56521 1.0 1.0 0.0 0 0 0 0 0 GO:0046782 6 regulation of viral transcription 13 13 3 3 1 1 0 0 68 13 2466 0.70283 1.0 1.0 0.0 0 0 0 0 0 GO:0046785 6 microtubule polymerization 5 5 1 1 0 1 0 0 68 5 2474 0.87336 1.0 1.0 0.0 0 0 0 0 0 GO:0046834 6 lipid phosphorylation 13 14 1 1 1 0 0 0 68 14 2465 0.68397 1.0 1.0 0.0 0 0 0 0 0 GO:0046850 6 regulation of bone remodeling 20 20 1 1 0 0 0 0 68 20 2459 0.58084 1.0 1.0 0.0 0 0 0 0 0 GO:0046852 7 positive regulation of bone remodeling 11 11 1 1 0 0 0 0 68 11 2468 0.74211 1.0 1.0 0.0 0 0 0 0 0 GO:0046854 7 phosphatidylinositol phosphorylation 12 12 1 1 1 0 0 0 68 12 2467 0.72221 1.0 1.0 0.0 0 0 0 0 0 GO:0046885 6 regulation of hormone biosynthetic process 16 17 1 0 0 0 0 0 68 17 2462 0.63033 1.0 1.0 0.0 0 0 0 0 0 GO:0046886 7 positive regulation of hormone biosynthetic process 13 14 1 0 0 0 0 0 68 14 2465 0.68397 1.0 1.0 0.0 0 0 0 0 0 GO:0046888 6 negative regulation of hormone secretion 24 25 1 1 0 1 0 0 68 25 2454 0.50673 1.0 1.0 0.0 0 0 0 0 0 GO:0046889 7 positive regulation of lipid biosynthetic process 46 50 2 1 1 0 0 0 68 50 2429 0.25502 1.0 0.64318 0.0 0 0 0 0 0 GO:0046916 9 cellular transition metal ion homeostasis 20 23 3 2 1 1 0 0 68 23 2456 0.53518 1.0 1.0 0.0 0 0 0 0 0 GO:0048002 4 antigen processing and presentation of peptide antigen 16 25 1 1 0 0 0 0 68 25 2454 0.50673 1.0 1.0 0.0 0 0 0 0 0 GO:0048008 8 platelet-derived growth factor receptor signaling pathway 11 12 1 1 0 1 0 0 68 12 2467 0.72221 1.0 1.0 0.0 0 0 0 0 0 GO:0048010 8 vascular endothelial growth factor receptor signaling pathway 10 10 1 1 0 1 0 0 68 10 2469 0.76254 1.0 1.0 0.0 0 0 0 0 0 GO:0048012 8 hepatocyte growth factor receptor signaling pathway 6 6 1 1 0 0 0 0 68 6 2473 0.84999 1.0 1.0 0.0 0 0 0 0 0 GO:0048015 7 phosphatidylinositol-mediated signaling 19 20 1 1 1 0 0 0 68 20 2459 0.58084 1.0 1.0 0.0 0 0 0 0 0 GO:0048017 6 inositol lipid-mediated signaling 19 20 1 1 1 0 0 0 68 20 2459 0.58084 1.0 1.0 0.0 0 0 0 0 0 GO:0048021 7 regulation of melanin biosynthetic process 3 3 1 1 1 0 0 0 68 3 2476 0.922 1.0 1.0 0.0 0 0 0 0 0 GO:0048023 8 positive regulation of melanin biosynthetic process 1 1 1 1 1 0 0 0 68 1 2478 0.9733 1.0 1.0 0.0 0 0 0 0 0 GO:0048168 6 regulation of neuronal synaptic plasticity 24 25 1 1 0 0 0 0 68 25 2454 0.50673 1.0 1.0 0.0 0 0 0 0 0 GO:0048169 7 regulation of long-term neuronal synaptic plasticity 15 16 1 1 0 0 0 0 68 16 2463 0.64774 1.0 1.0 0.0 0 0 0 0 0 GO:0048172 7 regulation of short-term neuronal synaptic plasticity 2 2 1 1 0 0 0 0 68 2 2477 0.94731 1.0 1.0 0.0 0 0 0 0 0 GO:0048246 7 macrophage chemotaxis 4 4 1 1 0 1 0 0 68 4 2475 0.89735 1.0 1.0 0.0 0 0 0 0 0 GO:0048255 7 mRNA stabilization 10 10 1 1 1 0 0 0 68 10 2469 0.76254 1.0 1.0 0.0 0 0 0 0 0 GO:0048268 8 clathrin coat assembly 4 4 1 1 1 0 0 0 68 4 2475 0.89735 1.0 1.0 0.0 0 0 0 0 0 GO:0048302 8 regulation of isotype switching to IgG isotypes 5 5 1 1 1 0 0 0 68 5 2474 0.87336 1.0 1.0 0.0 0 0 0 0 0 GO:0048304 9 positive regulation of isotype switching to IgG isotypes 5 5 1 1 1 0 0 0 68 5 2474 0.87336 1.0 1.0 0.0 0 0 0 0 0 GO:0048485 5 sympathetic nervous system development 6 7 1 1 0 0 0 0 68 7 2472 0.82725 1.0 1.0 0.0 0 0 0 0 0 GO:0048534 5 hematopoietic or lymphoid organ development 55 60 2 2 1 0 0 0 68 60 2419 0.19339 1.0 0.40776 0.0 0 0 0 0 0 GO:0048539 5 bone marrow development 3 3 1 1 1 0 0 0 68 3 2476 0.922 1.0 1.0 0.0 0 0 0 0 0 GO:0048568 5 embryonic organ development 41 45 1 1 0 1 0 0 68 45 2434 0.29272 1.0 0.63214 0.0 0 0 0 0 0 GO:0048635 6 negative regulation of muscle organ development 22 22 1 0 0 0 0 0 68 22 2457 0.55 1.0 1.0 0.0 0 0 0 0 0 GO:0048640 6 negative regulation of developmental growth 30 32 2 1 0 0 0 0 68 32 2447 0.41839 1.0 1.0 0.0 0 0 0 0 0 GO:0048670 8 regulation of collateral sprouting 3 3 1 1 0 0 0 0 68 3 2476 0.922 1.0 1.0 0.0 0 0 0 0 0 GO:0048671 8 negative regulation of collateral sprouting 2 2 1 1 0 0 0 0 68 2 2477 0.94731 1.0 1.0 0.0 0 0 0 0 0 GO:0048679 8 regulation of axon regeneration 5 6 1 1 0 0 0 0 68 6 2473 0.84999 1.0 1.0 0.0 0 0 0 0 0 GO:0048681 8 negative regulation of axon regeneration 1 1 1 1 0 0 0 0 68 1 2478 0.9733 1.0 1.0 0.0 0 0 0 0 0 GO:0048683 9 regulation of collateral sprouting of intact axon in response to injury 1 1 1 1 0 0 0 0 68 1 2478 0.9733 1.0 1.0 0.0 0 0 0 0 0 GO:0048685 9 negative regulation of collateral sprouting of intact axon in response to injury 1 1 1 1 0 0 0 0 68 1 2478 0.9733 1.0 1.0 0.0 0 0 0 0 0 GO:0048705 5 skeletal system morphogenesis 20 21 1 1 0 1 0 0 68 21 2458 0.56521 1.0 1.0 0.0 0 0 0 0 0 GO:0048806 5 genitalia development 11 11 2 1 0 1 0 0 68 11 2468 0.74211 1.0 1.0 0.0 0 0 0 0 0 GO:0048817 8 negative regulation of hair follicle maturation 1 1 1 1 1 0 0 0 68 1 2478 0.9733 1.0 1.0 0.0 0 0 0 0 0 GO:0048819 7 regulation of hair follicle maturation 2 2 1 1 1 0 0 0 68 2 2477 0.94731 1.0 1.0 0.0 0 0 0 0 0 GO:0048821 6 erythrocyte development 8 9 3 3 2 0 0 0 68 9 2470 0.78354 1.0 1.0 0.0 0 0 0 0 0 GO:0048839 4 inner ear development 22 23 1 1 0 1 0 0 68 23 2456 0.53518 1.0 1.0 0.0 0 0 0 0 0 GO:0048864 5 stem cell development 8 8 1 1 1 0 0 0 68 8 2471 0.8051 1.0 1.0 0.0 0 0 0 0 0 GO:0048872 5 homeostasis of number of cells 46 48 1 1 0 1 0 0 68 48 2431 0.26949 1.0 0.63832 0.0 0 0 0 0 0 GO:0050434 6 positive regulation of viral transcription 7 7 2 2 1 0 0 0 68 7 2472 0.82725 1.0 1.0 0.0 0 0 0 0 0 GO:0050663 6 cytokine secretion 13 15 1 1 0 1 0 0 68 15 2464 0.66561 1.0 1.0 0.0 0 0 0 0 0 GO:0050671 8 positive regulation of lymphocyte proliferation 47 51 1 1 1 0 0 0 68 51 2428 0.24807 1.0 0.64581 0.0 0 0 0 0 0 GO:0050709 7 negative regulation of protein secretion 32 34 2 2 0 1 0 0 68 34 2445 0.39607 1.0 1.0 0.0 0 0 0 0 0 GO:0050710 6 negative regulation of cytokine secretion 13 14 1 1 0 0 0 0 68 14 2465 0.68397 1.0 1.0 0.0 0 0 0 0 0 GO:0050805 6 negative regulation of synaptic transmission 19 19 2 2 1 0 0 0 68 19 2460 0.5969 1.0 1.0 0.0 0 0 0 0 0 GO:0050806 6 positive regulation of synaptic transmission 48 51 3 3 1 1 0 0 68 51 2428 0.24807 1.0 0.64581 0.0 0 0 0 0 0 GO:0050830 6 defense response to Gram-positive bacterium 27 33 1 1 0 0 0 0 68 33 2446 0.40708 1.0 1.0 0.0 0 0 0 0 0 GO:0050848 7 regulation of calcium-mediated signaling 33 35 1 1 0 0 0 0 68 35 2444 0.38535 1.0 1.0 0.0 0 0 0 0 0 GO:0050849 8 negative regulation of calcium-mediated signaling 9 10 1 1 0 0 0 0 68 10 2469 0.76254 1.0 1.0 0.0 0 0 0 0 0 GO:0050850 8 positive regulation of calcium-mediated signaling 20 21 1 1 0 0 0 0 68 21 2458 0.56521 1.0 1.0 0.0 0 0 0 0 0 GO:0050853 9 B cell receptor signaling pathway 13 14 1 1 1 0 0 0 68 14 2465 0.68397 1.0 1.0 0.0 0 0 0 0 0 GO:0050855 7 regulation of B cell receptor signaling pathway 6 7 1 1 1 0 0 0 68 7 2472 0.82725 1.0 1.0 0.0 0 0 0 0 0 GO:0050857 7 positive regulation of antigen receptor-mediated signaling pathway 8 9 2 2 2 0 0 0 68 9 2470 0.78354 1.0 1.0 0.0 0 0 0 0 0 GO:0050861 8 positive regulation of B cell receptor signaling pathway 4 5 1 1 1 0 0 0 68 5 2474 0.87336 1.0 1.0 0.0 0 0 0 0 0 GO:0050864 7 regulation of B cell activation 41 43 1 1 1 0 0 0 68 43 2436 0.3093 1.0 0.6289 0.0 0 0 0 0 0 GO:0050871 8 positive regulation of B cell activation 27 29 1 1 1 0 0 0 68 29 2450 0.45422 1.0 1.0 0.0 0 0 0 0 0 GO:0050873 6 brown fat cell differentiation 15 17 2 1 1 0 0 0 68 17 2462 0.63033 1.0 1.0 0.0 0 0 0 0 0 GO:0050886 4 endocrine process 7 10 1 1 0 1 0 0 68 10 2469 0.76254 1.0 1.0 0.0 0 0 0 0 0 GO:0050906 4 detection of stimulus involved in sensory perception 21 22 1 1 0 0 0 0 68 22 2457 0.55 1.0 1.0 0.0 0 0 0 0 0 GO:0050919 5 negative chemotaxis 5 5 1 1 0 1 0 0 68 5 2474 0.87336 1.0 1.0 0.0 0 0 0 0 0 GO:0050960 6 detection of temperature stimulus involved in thermoception 1 1 1 1 0 0 0 0 68 1 2478 0.9733 1.0 1.0 0.0 0 0 0 0 0 GO:0050961 5 detection of temperature stimulus involved in sensory perception 6 6 1 1 0 0 0 0 68 6 2473 0.84999 1.0 1.0 0.0 0 0 0 0 0 GO:0051048 6 negative regulation of secretion 62 66 3 3 0 2 0 0 68 66 2413 0.16373 1.0 0.42113 0.0 0 0 0 0 0 GO:0051055 7 negative regulation of lipid biosynthetic process 19 19 1 1 0 1 0 0 68 19 2460 0.5969 1.0 1.0 0.0 0 0 0 0 0 GO:0051081 7 nuclear envelope disassembly 3 3 1 1 1 0 0 0 68 3 2476 0.922 1.0 1.0 0.0 0 0 0 0 0 GO:0051084 5 'de novo' posttranslational protein folding 12 16 1 1 0 0 0 0 68 16 2463 0.64774 1.0 1.0 0.0 0 0 0 0 0 GO:0051085 5 chaperone cofactor-dependent protein refolding 9 13 1 1 0 0 0 0 68 13 2466 0.70283 1.0 1.0 0.0 0 0 0 0 0 GO:0051100 5 negative regulation of binding 52 53 4 4 1 2 0 0 68 53 2426 0.23474 1.0 0.40133 0.0 0 0 0 0 0 GO:0051209 12 release of sequestered calcium ion into cytosol 20 20 1 1 1 0 0 0 68 20 2459 0.58084 1.0 1.0 0.0 0 0 0 0 0 GO:0051224 6 negative regulation of protein transport 47 51 2 2 0 1 0 0 68 51 2428 0.24807 1.0 0.64581 0.0 0 0 0 0 0 GO:0051255 4 spindle midzone assembly 3 4 1 1 1 0 0 0 68 4 2475 0.89735 1.0 1.0 0.0 0 0 0 0 0 GO:0051256 5 mitotic spindle midzone assembly 3 4 1 1 1 0 0 0 68 4 2475 0.89735 1.0 1.0 0.0 0 0 0 0 0 GO:0051280 6 negative regulation of release of sequestered calcium ion into cytosol 5 5 1 1 0 0 0 0 68 5 2474 0.87336 1.0 1.0 0.0 0 0 0 0 0 GO:0051283 5 negative regulation of sequestering of calcium ion 20 20 1 1 1 0 0 0 68 20 2459 0.58084 1.0 1.0 0.0 0 0 0 0 0 GO:0051284 5 positive regulation of sequestering of calcium ion 5 5 1 1 0 0 0 0 68 5 2474 0.87336 1.0 1.0 0.0 0 0 0 0 0 GO:0051293 6 establishment of spindle localization 10 10 1 1 1 0 0 0 68 10 2469 0.76254 1.0 1.0 0.0 0 0 0 0 0 GO:0051294 7 establishment of spindle orientation 8 8 1 1 1 0 0 0 68 8 2471 0.8051 1.0 1.0 0.0 0 0 0 0 0 GO:0051315 5 attachment of mitotic spindle microtubules to kinetochore 3 3 1 1 0 0 0 0 68 3 2476 0.922 1.0 1.0 0.0 0 0 0 0 0 GO:0051353 6 positive regulation of oxidoreductase activity 20 23 1 1 1 0 0 0 68 23 2456 0.53518 1.0 1.0 0.0 0 0 0 0 0 GO:0051383 7 kinetochore organization 9 9 1 1 0 0 0 0 68 9 2470 0.78354 1.0 1.0 0.0 0 0 0 0 0 GO:0051385 7 response to mineralocorticoid 32 37 1 1 0 1 0 0 68 37 2442 0.36477 1.0 0.62433 0.0 0 0 0 0 0 GO:0051402 5 neuron apoptotic process 23 25 1 1 0 0 0 0 68 25 2454 0.50673 1.0 1.0 0.0 0 0 0 0 0 GO:0051410 3 detoxification of nitrogen compound 2 4 1 1 0 0 0 0 68 4 2475 0.89735 1.0 1.0 0.0 0 0 0 0 0 GO:0051412 6 response to corticosterone 23 27 1 1 0 1 0 0 68 27 2452 0.47977 1.0 1.0 0.0 0 0 0 0 0 GO:0051438 8 regulation of ubiquitin-protein transferase activity 15 16 1 1 1 0 0 0 68 16 2463 0.64774 1.0 1.0 0.0 0 0 0 0 0 GO:0051443 9 positive regulation of ubiquitin-protein transferase activity 9 9 1 1 1 0 0 0 68 9 2470 0.78354 1.0 1.0 0.0 0 0 0 0 0 GO:0051450 4 myoblast proliferation 4 4 1 1 0 0 0 0 68 4 2475 0.89735 1.0 1.0 0.0 0 0 0 0 0 GO:0051482 12 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway 7 7 1 1 0 1 0 0 68 7 2472 0.82725 1.0 1.0 0.0 0 0 0 0 0 GO:0051492 7 regulation of stress fiber assembly 24 27 1 1 0 1 0 0 68 27 2452 0.47977 1.0 1.0 0.0 0 0 0 0 0 GO:0051496 8 positive regulation of stress fiber assembly 18 21 1 1 0 1 0 0 68 21 2458 0.56521 1.0 1.0 0.0 0 0 0 0 0 GO:0051580 5 regulation of neurotransmitter uptake 8 9 1 0 0 0 0 0 68 9 2470 0.78354 1.0 1.0 0.0 0 0 0 0 0 GO:0051581 6 negative regulation of neurotransmitter uptake 3 4 1 0 0 0 0 0 68 4 2475 0.89735 1.0 1.0 0.0 0 0 0 0 0 GO:0051588 6 regulation of neurotransmitter transport 35 42 1 0 0 0 0 0 68 42 2437 0.31793 1.0 0.62756 0.0 0 0 0 0 0 GO:0051589 6 negative regulation of neurotransmitter transport 9 10 1 0 0 0 0 0 68 10 2469 0.76254 1.0 1.0 0.0 0 0 0 0 0 GO:0051606 3 detection of stimulus 47 49 2 2 0 0 0 0 68 49 2430 0.26216 1.0 0.64068 0.0 0 0 0 0 0 GO:0051653 4 spindle localization 12 12 1 1 1 0 0 0 68 12 2467 0.72221 1.0 1.0 0.0 0 0 0 0 0 GO:0051665 5 membrane raft localization 2 2 1 1 1 0 0 0 68 2 2477 0.94731 1.0 1.0 0.0 0 0 0 0 0 GO:0051702 3 interaction with symbiont 33 36 4 4 1 1 0 0 68 36 2443 0.37492 1.0 0.62447 0.0 0 0 0 0 0 GO:0051770 8 positive regulation of nitric-oxide synthase biosynthetic process 8 8 1 1 0 1 0 0 68 8 2471 0.8051 1.0 1.0 0.0 0 0 0 0 0 GO:0051794 8 regulation of timing of catagen 1 1 1 1 1 0 0 0 68 1 2478 0.9733 1.0 1.0 0.0 0 0 0 0 0 GO:0051796 9 negative regulation of timing of catagen 1 1 1 1 1 0 0 0 68 1 2478 0.9733 1.0 1.0 0.0 0 0 0 0 0 GO:0051797 6 regulation of hair follicle development 5 6 1 1 1 0 0 0 68 6 2473 0.84999 1.0 1.0 0.0 0 0 0 0 0 GO:0051799 7 negative regulation of hair follicle development 2 2 1 1 1 0 0 0 68 2 2477 0.94731 1.0 1.0 0.0 0 0 0 0 0 GO:0051851 4 modulation by host of symbiont process 21 22 3 3 1 1 0 0 68 22 2457 0.55 1.0 1.0 0.0 0 0 0 0 0 GO:0051899 5 membrane depolarization 10 10 1 1 0 0 0 0 68 10 2469 0.76254 1.0 1.0 0.0 0 0 0 0 0 GO:0051901 6 positive regulation of mitochondrial depolarization 4 4 1 1 0 1 0 0 68 4 2475 0.89735 1.0 1.0 0.0 0 0 0 0 0 GO:0051923 5 sulfation 5 8 1 1 0 1 0 0 68 8 2471 0.8051 1.0 1.0 0.0 0 0 0 0 0 GO:0051926 7 negative regulation of calcium ion transport 19 21 2 2 1 0 0 0 68 21 2458 0.56521 1.0 1.0 0.0 0 0 0 0 0 GO:0051953 6 negative regulation of amine transport 9 10 1 0 0 0 0 0 68 10 2469 0.76254 1.0 1.0 0.0 0 0 0 0 0 GO:0051956 7 negative regulation of amino acid transport 4 5 1 0 0 0 0 0 68 5 2474 0.87336 1.0 1.0 0.0 0 0 0 0 0 GO:0051966 7 regulation of synaptic transmission, glutamatergic 17 18 3 3 1 1 0 0 68 18 2461 0.61339 1.0 1.0 0.0 0 0 0 0 0 GO:0051967 7 negative regulation of synaptic transmission, glutamatergic 2 2 1 1 0 0 0 0 68 2 2477 0.94731 1.0 1.0 0.0 0 0 0 0 0 GO:0051968 7 positive regulation of synaptic transmission, glutamatergic 8 9 2 2 1 1 0 0 68 9 2470 0.78354 1.0 1.0 0.0 0 0 0 0 0 GO:0052372 5 modulation by symbiont of entry into host 11 11 1 1 0 0 0 0 68 11 2468 0.74211 1.0 1.0 0.0 0 0 0 0 0 GO:0055008 6 cardiac muscle tissue morphogenesis 15 16 1 1 0 1 0 0 68 16 2463 0.64774 1.0 1.0 0.0 0 0 0 0 0 GO:0055010 7 ventricular cardiac muscle tissue morphogenesis 12 13 1 1 0 1 0 0 68 13 2466 0.70283 1.0 1.0 0.0 0 0 0 0 0 GO:0055021 7 regulation of cardiac muscle tissue growth 28 29 1 0 0 0 0 0 68 29 2450 0.45422 1.0 1.0 0.0 0 0 0 0 0 GO:0055022 8 negative regulation of cardiac muscle tissue growth 11 11 1 0 0 0 0 0 68 11 2468 0.74211 1.0 1.0 0.0 0 0 0 0 0 GO:0055024 7 regulation of cardiac muscle tissue development 35 37 1 0 0 0 0 0 68 37 2442 0.36477 1.0 0.62433 0.0 0 0 0 0 0 GO:0055026 8 negative regulation of cardiac muscle tissue development 14 14 1 0 0 0 0 0 68 14 2465 0.68397 1.0 1.0 0.0 0 0 0 0 0 GO:0055062 9 phosphate ion homeostasis 3 3 1 1 0 0 0 0 68 3 2476 0.922 1.0 1.0 0.0 0 0 0 0 0 GO:0055064 9 chloride ion homeostasis 5 5 1 1 0 0 0 0 68 5 2474 0.87336 1.0 1.0 0.0 0 0 0 0 0 GO:0055067 8 monovalent inorganic cation homeostasis 21 23 2 2 0 1 0 0 68 23 2456 0.53518 1.0 1.0 0.0 0 0 0 0 0 GO:0055072 10 iron ion homeostasis 18 18 4 3 1 2 0 0 68 18 2461 0.61339 1.0 1.0 0.0 0 0 0 0 0 GO:0055076 9 transition metal ion homeostasis 23 26 4 3 1 2 0 0 68 26 2453 0.49307 1.0 1.0 0.0 0 0 0 0 0 GO:0055078 9 sodium ion homeostasis 6 7 1 1 0 0 0 0 68 7 2472 0.82725 1.0 1.0 0.0 0 0 0 0 0 GO:0055081 7 anion homeostasis 21 21 1 1 0 0 0 0 68 21 2458 0.56521 1.0 1.0 0.0 0 0 0 0 0 GO:0055083 8 monovalent inorganic anion homeostasis 7 7 1 1 0 0 0 0 68 7 2472 0.82725 1.0 1.0 0.0 0 0 0 0 0 GO:0055117 8 regulation of cardiac muscle contraction 9 10 1 0 0 0 0 0 68 10 2469 0.76254 1.0 1.0 0.0 0 0 0 0 0 GO:0055119 6 relaxation of cardiac muscle 3 3 1 0 0 0 0 0 68 3 2476 0.922 1.0 1.0 0.0 0 0 0 0 0 GO:0060048 7 cardiac muscle contraction 23 23 1 1 0 1 0 0 68 23 2456 0.53518 1.0 1.0 0.0 0 0 0 0 0 GO:0060070 8 canonical Wnt signaling pathway 13 16 2 2 2 0 0 0 68 16 2463 0.64774 1.0 1.0 0.0 0 0 0 0 0 GO:0060080 6 inhibitory postsynaptic potential 3 3 1 1 0 0 0 0 68 3 2476 0.922 1.0 1.0 0.0 0 0 0 0 0 GO:0060087 7 relaxation of vascular smooth muscle 2 2 1 0 0 0 0 0 68 2 2477 0.94731 1.0 1.0 0.0 0 0 0 0 0 GO:0060174 4 limb bud formation 2 2 1 1 0 0 0 0 68 2 2477 0.94731 1.0 1.0 0.0 0 0 0 0 0 GO:0060191 6 regulation of lipase activity 26 27 2 1 0 1 0 0 68 27 2452 0.47977 1.0 1.0 0.0 0 0 0 0 0 GO:0060192 7 negative regulation of lipase activity 9 10 1 0 0 0 0 0 68 10 2469 0.76254 1.0 1.0 0.0 0 0 0 0 0 GO:0060193 7 positive regulation of lipase activity 18 18 1 1 0 1 0 0 68 18 2461 0.61339 1.0 1.0 0.0 0 0 0 0 0 GO:0060236 7 regulation of mitotic spindle organization 10 10 1 1 1 0 0 0 68 10 2469 0.76254 1.0 1.0 0.0 0 0 0 0 0 GO:0060271 7 cilium assembly 15 16 2 2 0 2 0 0 68 16 2463 0.64774 1.0 1.0 0.0 0 0 0 0 0 GO:0060314 6 regulation of ryanodine-sensitive calcium-release channel activity 5 5 1 1 0 0 0 0 68 5 2474 0.87336 1.0 1.0 0.0 0 0 0 0 0 GO:0060315 7 negative regulation of ryanodine-sensitive calcium-release channel activity 3 3 1 1 0 0 0 0 68 3 2476 0.922 1.0 1.0 0.0 0 0 0 0 0 GO:0060316 12 positive regulation of ryanodine-sensitive calcium-release channel activity 3 3 1 1 0 0 0 0 68 3 2476 0.922 1.0 1.0 0.0 0 0 0 0 0 GO:0060325 4 face morphogenesis 13 13 1 1 0 1 0 0 68 13 2466 0.70283 1.0 1.0 0.0 0 0 0 0 0 GO:0060337 7 type I interferon signaling pathway 5 5 1 1 0 0 0 0 68 5 2474 0.87336 1.0 1.0 0.0 0 0 0 0 0 GO:0060343 4 trabecula formation 7 7 1 1 0 1 0 0 68 7 2472 0.82725 1.0 1.0 0.0 0 0 0 0 0 GO:0060346 5 bone trabecula formation 3 3 1 1 0 1 0 0 68 3 2476 0.922 1.0 1.0 0.0 0 0 0 0 0 GO:0060353 5 regulation of cell adhesion molecule production 7 7 1 1 0 1 0 0 68 7 2472 0.82725 1.0 1.0 0.0 0 0 0 0 0 GO:0060355 6 positive regulation of cell adhesion molecule production 4 4 1 1 0 1 0 0 68 4 2475 0.89735 1.0 1.0 0.0 0 0 0 0 0 GO:0060368 6 regulation of Fc receptor mediated stimulatory signaling pathway 4 5 1 1 1 0 0 0 68 5 2474 0.87336 1.0 1.0 0.0 0 0 0 0 0 GO:0060369 7 positive regulation of Fc receptor mediated stimulatory signaling pathway 2 2 1 1 1 0 0 0 68 2 2477 0.94731 1.0 1.0 0.0 0 0 0 0 0 GO:0060390 7 regulation of SMAD protein signal transduction 9 9 1 0 0 0 0 0 68 9 2470 0.78354 1.0 1.0 0.0 0 0 0 0 0 GO:0060391 8 positive regulation of SMAD protein signal transduction 9 9 1 0 0 0 0 0 68 9 2470 0.78354 1.0 1.0 0.0 0 0 0 0 0 GO:0060393 7 regulation of pathway-restricted SMAD protein phosphorylation 18 18 1 0 0 0 0 0 68 18 2461 0.61339 1.0 1.0 0.0 0 0 0 0 0 GO:0060401 10 cytosolic calcium ion transport 28 28 1 1 1 0 0 0 68 28 2451 0.46682 1.0 1.0 0.0 0 0 0 0 0 GO:0060402 12 calcium ion transport into cytosol 27 27 1 1 1 0 0 0 68 27 2452 0.47977 1.0 1.0 0.0 0 0 0 0 0 GO:0060411 4 cardiac septum morphogenesis 16 17 1 1 0 0 0 0 68 17 2462 0.63033 1.0 1.0 0.0 0 0 0 0 0 GO:0060412 5 ventricular septum morphogenesis 7 8 1 1 0 0 0 0 68 8 2471 0.8051 1.0 1.0 0.0 0 0 0 0 0 GO:0060413 5 atrial septum morphogenesis 2 2 1 1 0 0 0 0 68 2 2477 0.94731 1.0 1.0 0.0 0 0 0 0 0 GO:0060416 6 response to growth hormone 18 18 1 1 0 1 0 0 68 18 2461 0.61339 1.0 1.0 0.0 0 0 0 0 0 GO:0060420 6 regulation of heart growth 30 31 2 1 0 0 0 0 68 31 2448 0.43001 1.0 1.0 0.0 0 0 0 0 0 GO:0060452 8 positive regulation of cardiac muscle contraction 2 3 1 0 0 0 0 0 68 3 2476 0.922 1.0 1.0 0.0 0 0 0 0 0 GO:0060544 8 regulation of necroptotic process 10 10 1 1 0 0 0 0 68 10 2469 0.76254 1.0 1.0 0.0 0 0 0 0 0 GO:0060546 9 negative regulation of necroptotic process 8 8 1 1 0 0 0 0 68 8 2471 0.8051 1.0 1.0 0.0 0 0 0 0 0 GO:0060547 7 negative regulation of necrotic cell death 10 10 1 1 0 0 0 0 68 10 2469 0.76254 1.0 1.0 0.0 0 0 0 0 0 GO:0060562 5 epithelial tube morphogenesis 21 22 1 1 1 0 0 0 68 22 2457 0.55 1.0 1.0 0.0 0 0 0 0 0 GO:0060563 7 neuroepithelial cell differentiation 4 5 1 1 0 0 0 0 68 5 2474 0.87336 1.0 1.0 0.0 0 0 0 0 0 GO:0060586 7 multicellular organismal iron ion homeostasis 3 3 1 0 0 0 0 0 68 3 2476 0.922 1.0 1.0 0.0 0 0 0 0 0 GO:0060638 4 mesenchymal-epithelial cell signaling 3 4 1 1 0 0 0 0 68 4 2475 0.89735 1.0 1.0 0.0 0 0 0 0 0 GO:0060665 6 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling 2 2 1 1 0 0 0 0 68 2 2477 0.94731 1.0 1.0 0.0 0 0 0 0 0 GO:0060683 6 regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling 1 1 1 1 0 1 0 0 68 1 2478 0.9733 1.0 1.0 0.0 0 0 0 0 0 GO:0060684 4 epithelial-mesenchymal cell signaling 2 2 1 1 0 1 0 0 68 2 2477 0.94731 1.0 1.0 0.0 0 0 0 0 0 GO:0060688 5 regulation of morphogenesis of a branching structure 18 20 3 3 0 2 0 0 68 20 2459 0.58084 1.0 1.0 0.0 0 0 0 0 0 GO:0060693 6 regulation of branching involved in salivary gland morphogenesis 4 5 2 2 0 1 0 0 68 5 2474 0.87336 1.0 1.0 0.0 0 0 0 0 0 GO:0060706 4 cell differentiation involved in embryonic placenta development 11 11 1 0 0 1 0 0 68 11 2468 0.74211 1.0 1.0 0.0 0 0 0 0 0 GO:0060710 4 chorio-allantoic fusion 4 4 1 0 0 1 0 0 68 4 2475 0.89735 1.0 1.0 0.0 0 0 0 0 0 GO:0060715 5 syncytiotrophoblast cell differentiation involved in labyrinthine layer development 1 1 1 0 0 1 0 0 68 1 2478 0.9733 1.0 1.0 0.0 0 0 0 0 0 GO:0060717 5 chorion development 1 1 1 0 0 1 0 0 68 1 2478 0.9733 1.0 1.0 0.0 0 0 0 0 0 GO:0060740 4 prostate gland epithelium morphogenesis 13 13 1 1 0 1 0 0 68 13 2466 0.70283 1.0 1.0 0.0 0 0 0 0 0 GO:0060741 4 prostate gland stromal morphogenesis 2 2 1 1 1 0 0 0 68 2 2477 0.94731 1.0 1.0 0.0 0 0 0 0 0 GO:0060901 7 regulation of hair cycle by canonical Wnt signaling pathway 1 1 1 1 1 0 0 0 68 1 2478 0.9733 1.0 1.0 0.0 0 0 0 0 0 GO:0060992 5 response to fungicide 17 19 1 1 0 1 0 0 68 19 2460 0.5969 1.0 1.0 0.0 0 0 0 0 0 GO:0060993 5 kidney morphogenesis 4 4 2 2 1 0 0 0 68 4 2475 0.89735 1.0 1.0 0.0 0 0 0 0 0 GO:0061013 7 regulation of mRNA catabolic process 16 17 1 1 1 0 0 0 68 17 2462 0.63033 1.0 1.0 0.0 0 0 0 0 0 GO:0061029 4 eyelid development in camera-type eye 6 6 1 1 0 0 0 0 68 6 2473 0.84999 1.0 1.0 0.0 0 0 0 0 0 GO:0061037 6 negative regulation of cartilage development 4 4 1 1 0 0 0 0 68 4 2475 0.89735 1.0 1.0 0.0 0 0 0 0 0 GO:0061050 6 regulation of cell growth involved in cardiac muscle cell development 14 14 1 0 0 0 0 0 68 14 2465 0.68397 1.0 1.0 0.0 0 0 0 0 0 GO:0061052 7 negative regulation of cell growth involved in cardiac muscle cell development 5 5 1 0 0 0 0 0 68 5 2474 0.87336 1.0 1.0 0.0 0 0 0 0 0 GO:0061098 9 positive regulation of protein tyrosine kinase activity 12 14 1 1 0 0 0 0 68 14 2465 0.68397 1.0 1.0 0.0 0 0 0 0 0 GO:0061117 7 negative regulation of heart growth 11 11 1 0 0 0 0 0 68 11 2468 0.74211 1.0 1.0 0.0 0 0 0 0 0 GO:0061213 7 positive regulation of mesonephros development 9 9 1 1 0 1 0 0 68 9 2470 0.78354 1.0 1.0 0.0 0 0 0 0 0 GO:0061217 7 regulation of mesonephros development 9 9 1 1 0 1 0 0 68 9 2470 0.78354 1.0 1.0 0.0 0 0 0 0 0 GO:0061458 5 reproductive system development 6 6 2 1 0 1 0 0 68 6 2473 0.84999 1.0 1.0 0.0 0 0 0 0 0 GO:0061515 5 myeloid cell development 17 18 3 3 2 0 0 0 68 18 2461 0.61339 1.0 1.0 0.0 0 0 0 0 0 GO:0061951 7 establishment of protein localization to plasma membrane 4 4 1 1 1 0 0 0 68 4 2475 0.89735 1.0 1.0 0.0 0 0 0 0 0 GO:0061975 6 articular cartilage development 1 1 1 1 0 0 0 0 68 1 2478 0.9733 1.0 1.0 0.0 0 0 0 0 0 GO:0062098 7 regulation of programmed necrotic cell death 10 10 1 1 0 0 0 0 68 10 2469 0.76254 1.0 1.0 0.0 0 0 0 0 0 GO:0062099 8 negative regulation of programmed necrotic cell death 8 8 1 1 0 0 0 0 68 8 2471 0.8051 1.0 1.0 0.0 0 0 0 0 0 GO:0062237 7 protein localization to postsynapse 7 7 1 1 1 0 0 0 68 7 2472 0.82725 1.0 1.0 0.0 0 0 0 0 0 GO:0070167 5 regulation of biomineral tissue development 22 25 2 1 0 1 0 0 68 25 2454 0.50673 1.0 1.0 0.0 0 0 0 0 0 GO:0070169 6 positive regulation of biomineral tissue development 13 14 2 1 0 1 0 0 68 14 2465 0.68397 1.0 1.0 0.0 0 0 0 0 0 GO:0070192 5 chromosome organization involved in meiotic cell cycle 10 10 1 1 0 0 0 0 68 10 2469 0.76254 1.0 1.0 0.0 0 0 0 0 0 GO:0070193 7 synaptonemal complex organization 2 2 1 1 1 0 0 0 68 2 2477 0.94731 1.0 1.0 0.0 0 0 0 0 0 GO:0070194 6 synaptonemal complex disassembly 2 2 1 1 1 0 0 0 68 2 2477 0.94731 1.0 1.0 0.0 0 0 0 0 0 GO:0070206 8 protein trimerization 6 8 1 1 0 1 0 0 68 8 2471 0.8051 1.0 1.0 0.0 0 0 0 0 0 GO:0070207 9 protein homotrimerization 4 5 1 1 0 1 0 0 68 5 2474 0.87336 1.0 1.0 0.0 0 0 0 0 0 GO:0070265 4 necrotic cell death 9 9 1 1 0 0 0 0 68 9 2470 0.78354 1.0 1.0 0.0 0 0 0 0 0 GO:0070266 6 necroptotic process 8 8 1 1 0 0 0 0 68 8 2471 0.8051 1.0 1.0 0.0 0 0 0 0 0 GO:0070293 5 renal absorption 4 4 1 1 0 0 0 0 68 4 2475 0.89735 1.0 1.0 0.0 0 0 0 0 0 GO:0070458 4 cellular detoxification of nitrogen compound 2 4 1 1 0 0 0 0 68 4 2475 0.89735 1.0 1.0 0.0 0 0 0 0 0 GO:0070542 5 response to fatty acid 60 63 4 4 2 1 0 0 68 63 2416 0.17795 1.0 0.41365 0.0 0 0 0 0 0 GO:0070572 7 positive regulation of neuron projection regeneration 4 5 1 1 0 0 0 0 68 5 2474 0.87336 1.0 1.0 0.0 0 0 0 0 0 GO:0070588 8 calcium ion transmembrane transport 40 40 2 2 1 1 0 0 68 40 2439 0.3359 1.0 0.62555 0.0 0 0 0 0 0 GO:0070613 8 regulation of protein processing 22 24 1 1 0 0 0 0 68 24 2455 0.52077 1.0 1.0 0.0 0 0 0 0 0 GO:0070665 7 positive regulation of leukocyte proliferation 54 58 1 1 1 0 0 0 68 58 2421 0.20441 1.0 0.40481 0.0 0 0 0 0 0 GO:0070838 8 divalent metal ion transport 57 61 2 2 1 1 0 0 68 61 2418 0.18811 1.0 0.40953 0.0 0 0 0 0 0 GO:0070925 6 organelle assembly 79 80 3 3 1 2 0 0 68 80 2399 0.11084 1.0 0.27398 0.0 0 0 0 0 0 GO:0070997 4 neuron death 26 28 1 1 0 0 0 0 68 28 2451 0.46682 1.0 1.0 0.0 0 0 0 0 0 GO:0071071 7 regulation of phospholipid biosynthetic process 7 7 1 1 0 1 0 0 68 7 2472 0.82725 1.0 1.0 0.0 0 0 0 0 0 GO:0071072 8 negative regulation of phospholipid biosynthetic process 3 3 1 1 0 1 0 0 68 3 2476 0.922 1.0 1.0 0.0 0 0 0 0 0 GO:0071156 7 regulation of cell cycle arrest 20 21 1 1 0 0 0 0 68 21 2458 0.56521 1.0 1.0 0.0 0 0 0 0 0 GO:0071158 8 positive regulation of cell cycle arrest 13 13 1 1 0 0 0 0 68 13 2466 0.70283 1.0 1.0 0.0 0 0 0 0 0 GO:0071168 8 protein localization to chromatin 7 7 1 1 1 0 0 0 68 7 2472 0.82725 1.0 1.0 0.0 0 0 0 0 0 GO:0071243 5 cellular response to arsenic-containing substance 6 6 1 1 0 1 0 0 68 6 2473 0.84999 1.0 1.0 0.0 0 0 0 0 0 GO:0071284 7 cellular response to lead ion 4 4 2 2 1 1 0 0 68 4 2475 0.89735 1.0 1.0 0.0 0 0 0 0 0 GO:0071288 7 cellular response to mercury ion 3 4 1 1 0 0 0 0 68 4 2475 0.89735 1.0 1.0 0.0 0 0 0 0 0 GO:0071313 6 cellular response to caffeine 5 5 1 1 0 0 0 0 68 5 2474 0.87336 1.0 1.0 0.0 0 0 0 0 0 GO:0071318 6 cellular response to ATP 6 6 2 2 1 1 0 0 68 6 2473 0.84999 1.0 1.0 0.0 0 0 0 0 0 GO:0071359 6 cellular response to dsRNA 9 9 1 1 0 1 0 0 68 9 2470 0.78354 1.0 1.0 0.0 0 0 0 0 0 GO:0071360 7 cellular response to exogenous dsRNA 4 4 1 1 0 1 0 0 68 4 2475 0.89735 1.0 1.0 0.0 0 0 0 0 0 GO:0071361 6 cellular response to ethanol 11 15 1 1 1 0 0 0 68 15 2464 0.66561 1.0 1.0 0.0 0 0 0 0 0 GO:0071379 6 cellular response to prostaglandin stimulus 12 12 1 1 0 0 0 0 68 12 2467 0.72221 1.0 1.0 0.0 0 0 0 0 0 GO:0071380 7 cellular response to prostaglandin E stimulus 11 11 1 1 0 0 0 0 68 11 2468 0.74211 1.0 1.0 0.0 0 0 0 0 0 GO:0071394 6 cellular response to testosterone stimulus 7 8 2 2 0 1 0 0 68 8 2471 0.8051 1.0 1.0 0.0 0 0 0 0 0 GO:0071398 6 cellular response to fatty acid 37 38 2 2 0 1 0 0 68 38 2441 0.35488 1.0 0.62448 0.0 0 0 0 0 0 GO:0071403 5 cellular response to high density lipoprotein particle stimulus 3 3 1 1 0 1 0 0 68 3 2476 0.922 1.0 1.0 0.0 0 0 0 0 0 GO:0071415 6 cellular response to purine-containing compound 6 6 1 1 0 0 0 0 68 6 2473 0.84999 1.0 1.0 0.0 0 0 0 0 0 GO:0071471 6 cellular response to non-ionic osmotic stress 1 1 1 1 1 0 0 0 68 1 2478 0.9733 1.0 1.0 0.0 0 0 0 0 0 GO:0071480 7 cellular response to gamma radiation 15 15 1 1 1 0 0 0 68 15 2464 0.66561 1.0 1.0 0.0 0 0 0 0 0 GO:0071493 8 cellular response to UV-B 3 4 1 1 1 0 0 0 68 4 2475 0.89735 1.0 1.0 0.0 0 0 0 0 0 GO:0071498 5 cellular response to fluid shear stress 10 11 3 3 1 1 0 0 68 11 2468 0.74211 1.0 1.0 0.0 0 0 0 0 0 GO:0071622 7 regulation of granulocyte chemotaxis 22 22 1 1 0 1 0 0 68 22 2457 0.55 1.0 1.0 0.0 0 0 0 0 0 GO:0071634 6 regulation of transforming growth factor beta production 10 11 2 2 2 0 0 0 68 11 2468 0.74211 1.0 1.0 0.0 0 0 0 0 0 GO:0071635 7 negative regulation of transforming growth factor beta production 3 3 1 1 1 0 0 0 68 3 2476 0.922 1.0 1.0 0.0 0 0 0 0 0 GO:0071636 7 positive regulation of transforming growth factor beta production 4 5 1 1 1 0 0 0 68 5 2474 0.87336 1.0 1.0 0.0 0 0 0 0 0 GO:0071684 3 organism emergence from protective structure 6 6 1 1 1 0 0 0 68 6 2473 0.84999 1.0 1.0 0.0 0 0 0 0 0 GO:0071709 6 membrane assembly 5 5 1 1 0 1 0 0 68 5 2474 0.87336 1.0 1.0 0.0 0 0 0 0 0 GO:0071715 7 icosanoid transport 8 11 1 1 0 1 0 0 68 11 2468 0.74211 1.0 1.0 0.0 0 0 0 0 0 GO:0071867 6 response to monoamine 19 21 2 2 0 1 0 0 68 21 2458 0.56521 1.0 1.0 0.0 0 0 0 0 0 GO:0071868 6 cellular response to monoamine stimulus 14 14 1 1 0 1 0 0 68 14 2465 0.68397 1.0 1.0 0.0 0 0 0 0 0 GO:0071869 5 response to catecholamine 18 20 2 2 0 1 0 0 68 20 2459 0.58084 1.0 1.0 0.0 0 0 0 0 0 GO:0071870 6 cellular response to catecholamine stimulus 14 14 1 1 0 1 0 0 68 14 2465 0.68397 1.0 1.0 0.0 0 0 0 0 0 GO:0071871 6 response to epinephrine 8 9 2 2 0 1 0 0 68 9 2470 0.78354 1.0 1.0 0.0 0 0 0 0 0 GO:0071872 7 cellular response to epinephrine stimulus 5 5 1 1 0 1 0 0 68 5 2474 0.87336 1.0 1.0 0.0 0 0 0 0 0 GO:0071877 7 regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway 1 1 1 0 0 0 0 0 68 1 2478 0.9733 1.0 1.0 0.0 0 0 0 0 0 GO:0071902 9 positive regulation of protein serine/threonine kinase activity 93 101 3 3 1 1 0 0 68 101 2378 0.06148 1.0 0.11177 0.0 0 0 0 0 0 GO:0072044 5 collecting duct development 4 4 1 1 0 0 0 0 68 4 2475 0.89735 1.0 1.0 0.0 0 0 0 0 0 GO:0072091 6 regulation of stem cell proliferation 19 21 1 1 1 0 0 0 68 21 2458 0.56521 1.0 1.0 0.0 0 0 0 0 0 GO:0072124 7 regulation of glomerular mesangial cell proliferation 6 6 1 1 0 1 0 0 68 6 2473 0.84999 1.0 1.0 0.0 0 0 0 0 0 GO:0072175 5 epithelial tube formation 13 13 1 1 0 0 0 0 68 13 2466 0.70283 1.0 1.0 0.0 0 0 0 0 0 GO:0072215 7 regulation of metanephros development 10 10 1 1 0 1 0 0 68 10 2469 0.76254 1.0 1.0 0.0 0 0 0 0 0 GO:0072216 7 positive regulation of metanephros development 8 8 1 1 0 1 0 0 68 8 2471 0.8051 1.0 1.0 0.0 0 0 0 0 0 GO:0072331 6 signal transduction by p53 class mediator 28 29 1 1 0 0 0 0 68 29 2450 0.45422 1.0 1.0 0.0 0 0 0 0 0 GO:0072395 6 signal transduction involved in cell cycle checkpoint 10 10 2 2 1 0 0 0 68 10 2469 0.76254 1.0 1.0 0.0 0 0 0 0 0 GO:0072401 7 signal transduction involved in DNA integrity checkpoint 10 10 2 2 1 0 0 0 68 10 2469 0.76254 1.0 1.0 0.0 0 0 0 0 0 GO:0072413 7 signal transduction involved in mitotic cell cycle checkpoint 6 6 1 1 0 0 0 0 68 6 2473 0.84999 1.0 1.0 0.0 0 0 0 0 0 GO:0072422 7 signal transduction involved in DNA damage checkpoint 10 10 2 2 1 0 0 0 68 10 2469 0.76254 1.0 1.0 0.0 0 0 0 0 0 GO:0072425 8 signal transduction involved in G2 DNA damage checkpoint 4 4 1 1 1 0 0 0 68 4 2475 0.89735 1.0 1.0 0.0 0 0 0 0 0 GO:0072431 9 signal transduction involved in mitotic G1 DNA damage checkpoint 5 5 1 1 0 0 0 0 68 5 2474 0.87336 1.0 1.0 0.0 0 0 0 0 0 GO:0072501 8 cellular divalent inorganic anion homeostasis 2 2 1 1 0 0 0 0 68 2 2477 0.94731 1.0 1.0 0.0 0 0 0 0 0 GO:0072502 8 cellular trivalent inorganic anion homeostasis 2 2 1 1 0 0 0 0 68 2 2477 0.94731 1.0 1.0 0.0 0 0 0 0 0 GO:0072505 8 divalent inorganic anion homeostasis 3 3 1 1 0 0 0 0 68 3 2476 0.922 1.0 1.0 0.0 0 0 0 0 0 GO:0072506 8 trivalent inorganic anion homeostasis 3 3 1 1 0 0 0 0 68 3 2476 0.922 1.0 1.0 0.0 0 0 0 0 0 GO:0072511 7 divalent inorganic cation transport 59 63 2 2 1 1 0 0 68 63 2416 0.17795 1.0 0.41365 0.0 0 0 0 0 0 GO:0072521 5 purine-containing compound metabolic process 83 95 1 1 0 0 0 0 68 95 2384 0.072794 1.0 0.17992 0.0 0 0 0 0 0 GO:0072522 6 purine-containing compound biosynthetic process 35 40 1 1 0 0 0 0 68 40 2439 0.3359 1.0 0.62555 0.0 0 0 0 0 0 GO:0072608 7 interleukin-10 secretion 1 1 1 1 0 1 0 0 68 1 2478 0.9733 1.0 1.0 0.0 0 0 0 0 0 GO:0072643 7 interferon-gamma secretion 2 2 1 1 0 1 0 0 68 2 2477 0.94731 1.0 1.0 0.0 0 0 0 0 0 GO:0072659 7 protein localization to plasma membrane 31 33 2 2 1 1 0 0 68 33 2446 0.40708 1.0 1.0 0.0 0 0 0 0 0 GO:0072683 7 T cell extravasation 4 4 1 1 0 1 0 0 68 4 2475 0.89735 1.0 1.0 0.0 0 0 0 0 0 GO:0072684 9 mitochondrial tRNA 3'-trailer cleavage, endonucleolytic 1 1 1 1 0 1 0 0 68 1 2478 0.9733 1.0 1.0 0.0 0 0 0 0 0 GO:0072718 5 response to cisplatin 3 3 1 1 0 1 0 0 68 3 2476 0.922 1.0 1.0 0.0 0 0 0 0 0 GO:0072719 6 cellular response to cisplatin 3 3 1 1 0 1 0 0 68 3 2476 0.922 1.0 1.0 0.0 0 0 0 0 0 GO:0086097 7 phospholipase C-activating angiotensin-activated signaling pathway 1 1 1 1 0 1 0 0 68 1 2478 0.9733 1.0 1.0 0.0 0 0 0 0 0 GO:0090030 7 regulation of steroid hormone biosynthetic process 9 9 1 0 0 0 0 0 68 9 2470 0.78354 1.0 1.0 0.0 0 0 0 0 0 GO:0090031 8 positive regulation of steroid hormone biosynthetic process 6 6 1 0 0 0 0 0 68 6 2473 0.84999 1.0 1.0 0.0 0 0 0 0 0 GO:0090049 8 regulation of cell migration involved in sprouting angiogenesis 15 16 2 2 1 1 0 0 68 16 2463 0.64774 1.0 1.0 0.0 0 0 0 0 0 GO:0090050 9 positive regulation of cell migration involved in sprouting angiogenesis 9 10 2 2 1 1 0 0 68 10 2469 0.76254 1.0 1.0 0.0 0 0 0 0 0 GO:0090084 7 negative regulation of inclusion body assembly 7 7 2 1 0 1 0 0 68 7 2472 0.82725 1.0 1.0 0.0 0 0 0 0 0 GO:0090100 7 positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 30 31 1 0 0 0 0 0 68 31 2448 0.43001 1.0 1.0 0.0 0 0 0 0 0 GO:0090140 6 regulation of mitochondrial fission 8 8 1 1 0 1 0 0 68 8 2471 0.8051 1.0 1.0 0.0 0 0 0 0 0 GO:0090141 6 positive regulation of mitochondrial fission 6 6 1 1 0 1 0 0 68 6 2473 0.84999 1.0 1.0 0.0 0 0 0 0 0 GO:0090150 6 establishment of protein localization to membrane 20 21 1 1 1 0 0 0 68 21 2458 0.56521 1.0 1.0 0.0 0 0 0 0 0 GO:0090169 7 regulation of spindle assembly 6 6 1 1 1 0 0 0 68 6 2473 0.84999 1.0 1.0 0.0 0 0 0 0 0 GO:0090184 6 positive regulation of kidney development 16 16 2 2 0 2 0 0 68 16 2463 0.64774 1.0 1.0 0.0 0 0 0 0 0 GO:0090189 6 regulation of branching involved in ureteric bud morphogenesis 8 8 1 1 0 1 0 0 68 8 2471 0.8051 1.0 1.0 0.0 0 0 0 0 0 GO:0090190 7 positive regulation of branching involved in ureteric bud morphogenesis 8 8 1 1 0 1 0 0 68 8 2471 0.8051 1.0 1.0 0.0 0 0 0 0 0 GO:0090192 7 regulation of glomerulus development 8 8 1 1 0 1 0 0 68 8 2471 0.8051 1.0 1.0 0.0 0 0 0 0 0 GO:0090201 8 negative regulation of release of cytochrome c from mitochondria 8 8 1 1 0 0 0 0 68 8 2471 0.8051 1.0 1.0 0.0 0 0 0 0 0 GO:0090224 7 regulation of spindle organization 11 11 1 1 1 0 0 0 68 11 2468 0.74211 1.0 1.0 0.0 0 0 0 0 0 GO:0090264 6 regulation of immune complex clearance by monocytes and macrophages 1 1 1 1 0 1 0 0 68 1 2478 0.9733 1.0 1.0 0.0 0 0 0 0 0 GO:0090265 7 positive regulation of immune complex clearance by monocytes and macrophages 1 1 1 1 0 1 0 0 68 1 2478 0.9733 1.0 1.0 0.0 0 0 0 0 0 GO:0090270 6 regulation of fibroblast growth factor production 3 3 1 1 1 0 0 0 68 3 2476 0.922 1.0 1.0 0.0 0 0 0 0 0 GO:0090271 7 positive regulation of fibroblast growth factor production 2 2 1 1 1 0 0 0 68 2 2477 0.94731 1.0 1.0 0.0 0 0 0 0 0 GO:0090278 7 negative regulation of peptide hormone secretion 13 14 1 1 0 1 0 0 68 14 2465 0.68397 1.0 1.0 0.0 0 0 0 0 0 GO:0090279 9 regulation of calcium ion import 17 21 2 2 0 2 0 0 68 21 2458 0.56521 1.0 1.0 0.0 0 0 0 0 0 GO:0090280 8 positive regulation of calcium ion import 10 12 2 2 0 2 0 0 68 12 2467 0.72221 1.0 1.0 0.0 0 0 0 0 0 GO:0090288 6 negative regulation of cellular response to growth factor stimulus 32 35 1 1 0 1 0 0 68 35 2444 0.38535 1.0 1.0 0.0 0 0 0 0 0 GO:0090305 6 nucleic acid phosphodiester bond hydrolysis 28 32 2 2 1 1 0 0 68 32 2447 0.41839 1.0 1.0 0.0 0 0 0 0 0 GO:0090313 8 regulation of protein targeting to membrane 11 13 1 1 0 1 0 0 68 13 2466 0.70283 1.0 1.0 0.0 0 0 0 0 0 GO:0090314 8 positive regulation of protein targeting to membrane 11 13 1 1 0 1 0 0 68 13 2466 0.70283 1.0 1.0 0.0 0 0 0 0 0 GO:0090335 7 regulation of brown fat cell differentiation 3 3 1 1 1 0 0 0 68 3 2476 0.922 1.0 1.0 0.0 0 0 0 0 0 GO:0090336 8 positive regulation of brown fat cell differentiation 3 3 1 1 1 0 0 0 68 3 2476 0.922 1.0 1.0 0.0 0 0 0 0 0 GO:0090361 6 regulation of platelet-derived growth factor production 2 2 1 1 1 0 0 0 68 2 2477 0.94731 1.0 1.0 0.0 0 0 0 0 0 GO:0090362 7 positive regulation of platelet-derived growth factor production 1 1 1 1 1 0 0 0 68 1 2478 0.9733 1.0 1.0 0.0 0 0 0 0 0 GO:0090435 8 protein localization to nuclear envelope 1 1 1 1 1 0 0 0 68 1 2478 0.9733 1.0 1.0 0.0 0 0 0 0 0 GO:0090501 7 RNA phosphodiester bond hydrolysis 18 22 2 2 1 1 0 0 68 22 2457 0.55 1.0 1.0 0.0 0 0 0 0 0 GO:0090502 8 RNA phosphodiester bond hydrolysis, endonucleolytic 10 11 1 1 0 1 0 0 68 11 2468 0.74211 1.0 1.0 0.0 0 0 0 0 0 GO:0090503 8 RNA phosphodiester bond hydrolysis, exonucleolytic 7 7 1 1 1 0 0 0 68 7 2472 0.82725 1.0 1.0 0.0 0 0 0 0 0 GO:0097120 6 receptor localization to synapse 5 5 1 1 1 0 0 0 68 5 2474 0.87336 1.0 1.0 0.0 0 0 0 0 0 GO:0097164 4 ammonium ion metabolic process 9 10 1 1 0 1 0 0 68 10 2469 0.76254 1.0 1.0 0.0 0 0 0 0 0 GO:0097201 9 negative regulation of transcription from RNA polymerase II promoter in response to stress 8 8 2 2 0 0 0 0 68 8 2471 0.8051 1.0 1.0 0.0 0 0 0 0 0 GO:0097210 6 response to gonadotropin-releasing hormone 3 3 1 1 0 1 0 0 68 3 2476 0.922 1.0 1.0 0.0 0 0 0 0 0 GO:0097211 7 cellular response to gonadotropin-releasing hormone 2 2 1 1 0 1 0 0 68 2 2477 0.94731 1.0 1.0 0.0 0 0 0 0 0 GO:0097300 5 programmed necrotic cell death 9 9 1 1 0 0 0 0 68 9 2470 0.78354 1.0 1.0 0.0 0 0 0 0 0 GO:0097340 10 inhibition of cysteine-type endopeptidase activity 6 6 1 1 0 0 0 0 68 6 2473 0.84999 1.0 1.0 0.0 0 0 0 0 0 GO:0097341 10 zymogen inhibition 6 6 1 1 0 0 0 0 68 6 2473 0.84999 1.0 1.0 0.0 0 0 0 0 0 GO:0097549 7 chromatin organization involved in negative regulation of transcription 13 16 1 1 1 0 0 0 68 16 2463 0.64774 1.0 1.0 0.0 0 0 0 0 0 GO:0097553 13 calcium ion transmembrane import into cytosol 26 26 1 1 1 0 0 0 68 26 2453 0.49307 1.0 1.0 0.0 0 0 0 0 0 GO:0097756 7 negative regulation of blood vessel diameter 12 13 2 2 1 1 0 0 68 13 2466 0.70283 1.0 1.0 0.0 0 0 0 0 0 GO:0098586 6 cellular response to virus 13 13 1 1 1 0 0 0 68 13 2466 0.70283 1.0 1.0 0.0 0 0 0 0 0 GO:0098655 6 cation transmembrane transport 85 87 3 3 1 2 0 0 68 87 2392 0.091123 1.0 0.17135 0.0 0 0 0 0 0 GO:0098660 6 inorganic ion transmembrane transport 90 91 3 3 1 2 0 0 68 91 2388 0.081452 1.0 0.17462 0.0 0 0 0 0 0 GO:0098662 7 inorganic cation transmembrane transport 77 78 3 3 1 2 0 0 68 78 2401 0.11721 1.0 0.27011 0.0 0 0 0 0 0 GO:0098706 9 iron ion import across cell outer membrane 1 1 1 1 0 1 0 0 68 1 2478 0.9733 1.0 1.0 0.0 0 0 0 0 0 GO:0098727 3 maintenance of cell number 28 29 1 1 0 0 0 0 68 29 2450 0.45422 1.0 1.0 0.0 0 0 0 0 0 GO:0098742 5 cell-cell adhesion via plasma-membrane adhesion molecules 29 30 1 1 1 0 0 0 68 30 2449 0.44195 1.0 1.0 0.0 0 0 0 0 0 GO:0098814 8 spontaneous synaptic transmission 1 1 1 1 1 0 0 0 68 1 2478 0.9733 1.0 1.0 0.0 0 0 0 0 0 GO:0098876 5 vesicle-mediated transport to the plasma membrane 7 7 1 1 1 0 0 0 68 7 2472 0.82725 1.0 1.0 0.0 0 0 0 0 0 GO:0098877 6 neurotransmitter receptor transport to plasma membrane 3 3 1 1 1 0 0 0 68 3 2476 0.922 1.0 1.0 0.0 0 0 0 0 0 GO:0098887 8 neurotransmitter receptor transport, endosome to postsynaptic membrane 1 1 1 1 1 0 0 0 68 1 2478 0.9733 1.0 1.0 0.0 0 0 0 0 0 GO:0098969 7 neurotransmitter receptor transport to postsynaptic membrane 3 3 1 1 1 0 0 0 68 3 2476 0.922 1.0 1.0 0.0 0 0 0 0 0 GO:0099003 5 vesicle-mediated transport in synapse 19 21 1 1 1 0 0 0 68 21 2458 0.56521 1.0 1.0 0.0 0 0 0 0 0 GO:0099024 7 plasma membrane invagination 10 11 1 1 0 0 0 0 68 11 2468 0.74211 1.0 1.0 0.0 0 0 0 0 0 GO:0099072 4 regulation of postsynaptic membrane neurotransmitter receptor levels 12 12 1 1 1 0 0 0 68 12 2467 0.72221 1.0 1.0 0.0 0 0 0 0 0 GO:0099505 5 regulation of presynaptic membrane potential 4 4 1 1 0 0 0 0 68 4 2475 0.89735 1.0 1.0 0.0 0 0 0 0 0 GO:0099601 5 regulation of neurotransmitter receptor activity 16 16 1 1 0 1 0 0 68 16 2463 0.64774 1.0 1.0 0.0 0 0 0 0 0 GO:0099627 7 neurotransmitter receptor cycle 1 1 1 1 1 0 0 0 68 1 2478 0.9733 1.0 1.0 0.0 0 0 0 0 0 GO:0099630 7 postsynaptic neurotransmitter receptor cycle 1 1 1 1 1 0 0 0 68 1 2478 0.9733 1.0 1.0 0.0 0 0 0 0 0 GO:0099637 6 neurotransmitter receptor transport 9 9 1 1 1 0 0 0 68 9 2470 0.78354 1.0 1.0 0.0 0 0 0 0 0 GO:0099638 6 endosome to plasma membrane protein transport 1 1 1 1 1 0 0 0 68 1 2478 0.9733 1.0 1.0 0.0 0 0 0 0 0 GO:0099639 7 neurotransmitter receptor transport, endosome to plasma membrane 1 1 1 1 1 0 0 0 68 1 2478 0.9733 1.0 1.0 0.0 0 0 0 0 0 GO:0106049 6 regulation of cellular response to osmotic stress 4 4 1 1 1 0 0 0 68 4 2475 0.89735 1.0 1.0 0.0 0 0 0 0 0 GO:0110110 6 positive regulation of animal organ morphogenesis 33 35 1 1 0 1 0 0 68 35 2444 0.38535 1.0 1.0 0.0 0 0 0 0 0 GO:0110149 4 regulation of biomineralization 22 25 2 1 0 1 0 0 68 25 2454 0.50673 1.0 1.0 0.0 0 0 0 0 0 GO:0110151 5 positive regulation of biomineralization 13 14 2 1 0 1 0 0 68 14 2465 0.68397 1.0 1.0 0.0 0 0 0 0 0 GO:0110154 7 RNA decapping 3 3 1 1 1 0 0 0 68 3 2476 0.922 1.0 1.0 0.0 0 0 0 0 0 GO:0110156 8 methylguanosine-cap decapping 3 3 1 1 1 0 0 0 68 3 2476 0.922 1.0 1.0 0.0 0 0 0 0 0 GO:0120031 7 plasma membrane bounded cell projection assembly 36 38 2 2 0 2 0 0 68 38 2441 0.35488 1.0 0.62448 0.0 0 0 0 0 0 GO:0120169 7 detection of cold stimulus involved in thermoception 1 1 1 1 0 0 0 0 68 1 2478 0.9733 1.0 1.0 0.0 0 0 0 0 0 GO:0140052 5 cellular response to oxidised low-density lipoprotein particle stimulus 5 5 1 1 1 0 0 0 68 5 2474 0.87336 1.0 1.0 0.0 0 0 0 0 0 GO:0140053 6 mitochondrial gene expression 4 4 1 1 0 1 0 0 68 4 2475 0.89735 1.0 1.0 0.0 0 0 0 0 0 GO:0140131 8 positive regulation of lymphocyte chemotaxis 7 7 1 1 1 0 0 0 68 7 2472 0.82725 1.0 1.0 0.0 0 0 0 0 0 GO:0140193 6 regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process 1 1 1 0 0 0 0 0 68 1 2478 0.9733 1.0 1.0 0.0 0 0 0 0 0 GO:0140194 6 negative regulation of adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process 1 1 1 0 0 0 0 0 68 1 2478 0.9733 1.0 1.0 0.0 0 0 0 0 0 GO:0140353 5 lipid export from cell 2 3 1 1 0 1 0 0 68 3 2476 0.922 1.0 1.0 0.0 0 0 0 0 0 GO:0150077 7 regulation of neuroinflammatory response 8 9 1 1 1 0 0 0 68 9 2470 0.78354 1.0 1.0 0.0 0 0 0 0 0 GO:1900024 7 regulation of substrate adhesion-dependent cell spreading 16 18 1 1 0 1 0 0 68 18 2461 0.61339 1.0 1.0 0.0 0 0 0 0 0 GO:1900026 8 positive regulation of substrate adhesion-dependent cell spreading 12 14 1 1 0 1 0 0 68 14 2465 0.68397 1.0 1.0 0.0 0 0 0 0 0 GO:1900238 8 regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway 2 2 1 1 0 1 0 0 68 2 2477 0.94731 1.0 1.0 0.0 0 0 0 0 0 GO:1900271 6 regulation of long-term synaptic potentiation 13 15 1 1 1 0 0 0 68 15 2464 0.66561 1.0 1.0 0.0 0 0 0 0 0 GO:1900376 6 regulation of secondary metabolite biosynthetic process 3 3 1 1 1 0 0 0 68 3 2476 0.922 1.0 1.0 0.0 0 0 0 0 0 GO:1900378 7 positive regulation of secondary metabolite biosynthetic process 1 1 1 1 1 0 0 0 68 1 2478 0.9733 1.0 1.0 0.0 0 0 0 0 0 GO:1900407 6 regulation of cellular response to oxidative stress 37 41 1 1 0 0 0 0 68 41 2438 0.32679 1.0 0.62644 0.0 0 0 0 0 0 GO:1900408 6 negative regulation of cellular response to oxidative stress 25 26 1 1 0 0 0 0 68 26 2453 0.49307 1.0 1.0 0.0 0 0 0 0 0 GO:1900449 6 regulation of glutamate receptor signaling pathway 13 13 1 1 0 1 0 0 68 13 2466 0.70283 1.0 1.0 0.0 0 0 0 0 0 GO:1900451 7 positive regulation of glutamate receptor signaling pathway 6 6 1 1 0 1 0 0 68 6 2473 0.84999 1.0 1.0 0.0 0 0 0 0 0 GO:1900744 8 regulation of p38MAPK cascade 11 12 1 1 0 0 0 0 68 12 2467 0.72221 1.0 1.0 0.0 0 0 0 0 0 GO:1900746 6 regulation of vascular endothelial growth factor signaling pathway 3 3 1 1 0 1 0 0 68 3 2476 0.922 1.0 1.0 0.0 0 0 0 0 0 GO:1900747 7 negative regulation of vascular endothelial growth factor signaling pathway 2 2 1 1 0 1 0 0 68 2 2477 0.94731 1.0 1.0 0.0 0 0 0 0 0 GO:1900923 6 regulation of glycine import across plasma membrane 1 1 1 0 0 0 0 0 68 1 2478 0.9733 1.0 1.0 0.0 0 0 0 0 0 GO:1900924 7 negative regulation of glycine import across plasma membrane 1 1 1 0 0 0 0 0 68 1 2478 0.9733 1.0 1.0 0.0 0 0 0 0 0 GO:1901020 7 negative regulation of calcium ion transmembrane transporter activity 6 7 1 1 0 0 0 0 68 7 2472 0.82725 1.0 1.0 0.0 0 0 0 0 0 GO:1901031 7 regulation of response to reactive oxygen species 23 27 1 1 0 0 0 0 68 27 2452 0.47977 1.0 1.0 0.0 0 0 0 0 0 GO:1901032 7 negative regulation of response to reactive oxygen species 14 15 1 1 0 0 0 0 68 15 2464 0.66561 1.0 1.0 0.0 0 0 0 0 0 GO:1901160 5 primary amino compound metabolic process 5 6 1 1 0 1 0 0 68 6 2473 0.84999 1.0 1.0 0.0 0 0 0 0 0 GO:1901166 7 neural crest cell migration involved in autonomic nervous system development 2 2 1 1 0 0 0 0 68 2 2477 0.94731 1.0 1.0 0.0 0 0 0 0 0 GO:1901222 7 regulation of NIK/NF-kappaB signaling 28 29 1 1 0 0 0 0 68 29 2450 0.45422 1.0 1.0 0.0 0 0 0 0 0 GO:1901298 7 regulation of hydrogen peroxide-mediated programmed cell death 6 8 1 1 0 0 0 0 68 8 2471 0.8051 1.0 1.0 0.0 0 0 0 0 0 GO:1901299 8 negative regulation of hydrogen peroxide-mediated programmed cell death 5 5 1 1 0 0 0 0 68 5 2474 0.87336 1.0 1.0 0.0 0 0 0 0 0 GO:1901317 5 regulation of flagellated sperm motility 3 3 1 1 0 1 0 0 68 3 2476 0.922 1.0 1.0 0.0 0 0 0 0 0 GO:1901423 6 response to benzene 3 3 1 1 1 0 0 0 68 3 2476 0.922 1.0 1.0 0.0 0 0 0 0 0 GO:1901571 6 fatty acid derivative transport 8 11 1 1 0 1 0 0 68 11 2468 0.74211 1.0 1.0 0.0 0 0 0 0 0 GO:1901624 8 negative regulation of lymphocyte chemotaxis 1 1 1 1 0 1 0 0 68 1 2478 0.9733 1.0 1.0 0.0 0 0 0 0 0 GO:1901673 8 regulation of mitotic spindle assembly 5 5 1 1 1 0 0 0 68 5 2474 0.87336 1.0 1.0 0.0 0 0 0 0 0 GO:1901722 6 regulation of cell proliferation involved in kidney development 8 8 1 1 0 1 0 0 68 8 2471 0.8051 1.0 1.0 0.0 0 0 0 0 0 GO:1901862 6 negative regulation of muscle tissue development 21 21 1 0 0 0 0 0 68 21 2458 0.56521 1.0 1.0 0.0 0 0 0 0 0 GO:1902019 6 regulation of cilium-dependent cell motility 3 3 1 1 0 1 0 0 68 3 2476 0.922 1.0 1.0 0.0 0 0 0 0 0 GO:1902106 7 negative regulation of leukocyte differentiation 33 34 1 1 0 1 0 0 68 34 2445 0.39607 1.0 1.0 0.0 0 0 0 0 0 GO:1902107 7 positive regulation of leukocyte differentiation 58 62 3 3 1 0 0 0 68 62 2417 0.18296 1.0 0.4115 0.0 0 0 0 0 0 GO:1902115 6 regulation of organelle assembly 42 45 1 1 1 0 0 0 68 45 2434 0.29272 1.0 0.63214 0.0 0 0 0 0 0 GO:1902218 7 regulation of intrinsic apoptotic signaling pathway in response to osmotic stress 4 4 1 1 1 0 0 0 68 4 2475 0.89735 1.0 1.0 0.0 0 0 0 0 0 GO:1902219 8 negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress 3 3 1 1 1 0 0 0 68 3 2476 0.922 1.0 1.0 0.0 0 0 0 0 0 GO:1902369 8 negative regulation of RNA catabolic process 11 11 1 1 1 0 0 0 68 11 2468 0.74211 1.0 1.0 0.0 0 0 0 0 0 GO:1902373 8 negative regulation of mRNA catabolic process 11 11 1 1 1 0 0 0 68 11 2468 0.74211 1.0 1.0 0.0 0 0 0 0 0 GO:1902400 8 intracellular signal transduction involved in G1 DNA damage checkpoint 5 5 1 1 0 0 0 0 68 5 2474 0.87336 1.0 1.0 0.0 0 0 0 0 0 GO:1902402 8 signal transduction involved in mitotic DNA damage checkpoint 6 6 1 1 0 0 0 0 68 6 2473 0.84999 1.0 1.0 0.0 0 0 0 0 0 GO:1902403 8 signal transduction involved in mitotic DNA integrity checkpoint 6 6 1 1 0 0 0 0 68 6 2473 0.84999 1.0 1.0 0.0 0 0 0 0 0 GO:1902547 6 regulation of cellular response to vascular endothelial growth factor stimulus 3 3 1 1 0 1 0 0 68 3 2476 0.922 1.0 1.0 0.0 0 0 0 0 0 GO:1902548 7 negative regulation of cellular response to vascular endothelial growth factor stimulus 2 2 1 1 0 1 0 0 68 2 2477 0.94731 1.0 1.0 0.0 0 0 0 0 0 GO:1902721 8 negative regulation of prolactin secretion 1 1 1 1 0 1 0 0 68 1 2478 0.9733 1.0 1.0 0.0 0 0 0 0 0 GO:1902749 8 regulation of cell cycle G2/M phase transition 30 32 1 1 1 0 0 0 68 32 2447 0.41839 1.0 1.0 0.0 0 0 0 0 0 GO:1902750 9 negative regulation of cell cycle G2/M phase transition 15 16 1 1 1 0 0 0 68 16 2463 0.64774 1.0 1.0 0.0 0 0 0 0 0 GO:1902807 9 negative regulation of cell cycle G1/S phase transition 19 19 2 2 0 1 0 0 68 19 2460 0.5969 1.0 1.0 0.0 0 0 0 0 0 GO:1902908 6 regulation of melanosome transport 1 1 1 1 1 0 0 0 68 1 2478 0.9733 1.0 1.0 0.0 0 0 0 0 0 GO:1902910 6 positive regulation of melanosome transport 1 1 1 1 1 0 0 0 68 1 2478 0.9733 1.0 1.0 0.0 0 0 0 0 0 GO:1902914 10 regulation of protein polyubiquitination 5 5 1 1 0 0 0 0 68 5 2474 0.87336 1.0 1.0 0.0 0 0 0 0 0 GO:1902916 11 positive regulation of protein polyubiquitination 5 5 1 1 0 0 0 0 68 5 2474 0.87336 1.0 1.0 0.0 0 0 0 0 0 GO:1902932 7 positive regulation of alcohol biosynthetic process 13 14 1 0 0 0 0 0 68 14 2465 0.68397 1.0 1.0 0.0 0 0 0 0 0 GO:1903131 6 mononuclear cell differentiation 8 8 1 1 0 0 0 0 68 8 2471 0.8051 1.0 1.0 0.0 0 0 0 0 0 GO:1903170 8 negative regulation of calcium ion transmembrane transport 9 10 1 1 0 0 0 0 68 10 2469 0.76254 1.0 1.0 0.0 0 0 0 0 0 GO:1903201 6 regulation of oxidative stress-induced cell death 33 36 1 1 0 0 0 0 68 36 2443 0.37492 1.0 0.62447 0.0 0 0 0 0 0 GO:1903202 7 negative regulation of oxidative stress-induced cell death 25 26 1 1 0 0 0 0 68 26 2453 0.49307 1.0 1.0 0.0 0 0 0 0 0 GO:1903205 6 regulation of hydrogen peroxide-induced cell death 17 20 1 1 0 0 0 0 68 20 2459 0.58084 1.0 1.0 0.0 0 0 0 0 0 GO:1903206 7 negative regulation of hydrogen peroxide-induced cell death 14 15 1 1 0 0 0 0 68 15 2464 0.66561 1.0 1.0 0.0 0 0 0 0 0 GO:1903305 7 regulation of regulated secretory pathway 36 42 1 1 0 1 0 0 68 42 2437 0.31793 1.0 0.62756 0.0 0 0 0 0 0 GO:1903306 8 negative regulation of regulated secretory pathway 6 6 1 1 0 1 0 0 68 6 2473 0.84999 1.0 1.0 0.0 0 0 0 0 0 GO:1903311 7 regulation of mRNA metabolic process 28 31 1 1 1 0 0 0 68 31 2448 0.43001 1.0 1.0 0.0 0 0 0 0 0 GO:1903312 8 negative regulation of mRNA metabolic process 13 14 1 1 1 0 0 0 68 14 2465 0.68397 1.0 1.0 0.0 0 0 0 0 0 GO:1903317 7 regulation of protein maturation 23 25 2 2 0 0 0 0 68 25 2454 0.50673 1.0 1.0 0.0 0 0 0 0 0 GO:1903318 8 negative regulation of protein maturation 15 15 1 1 0 0 0 0 68 15 2464 0.66561 1.0 1.0 0.0 0 0 0 0 0 GO:1903319 8 positive regulation of protein maturation 6 7 1 1 0 0 0 0 68 7 2472 0.82725 1.0 1.0 0.0 0 0 0 0 0 GO:1903322 9 positive regulation of protein modification by small protein conjugation or removal 39 40 2 2 1 0 0 0 68 40 2439 0.3359 1.0 0.62555 0.0 0 0 0 0 0 GO:1903391 6 regulation of adherens junction organization 2 2 1 0 0 0 0 0 68 2 2477 0.94731 1.0 1.0 0.0 0 0 0 0 0 GO:1903392 7 negative regulation of adherens junction organization 2 2 1 0 0 0 0 0 68 2 2477 0.94731 1.0 1.0 0.0 0 0 0 0 0 GO:1903523 6 negative regulation of blood circulation 13 14 2 2 1 1 0 0 68 14 2465 0.68397 1.0 1.0 0.0 0 0 0 0 0 GO:1903531 6 negative regulation of secretion by cell 58 60 3 3 0 2 0 0 68 60 2419 0.19339 1.0 0.40776 0.0 0 0 0 0 0 GO:1903533 8 regulation of protein targeting 19 21 1 1 0 1 0 0 68 21 2458 0.56521 1.0 1.0 0.0 0 0 0 0 0 GO:1903539 7 protein localization to postsynaptic membrane 6 6 1 1 1 0 0 0 68 6 2473 0.84999 1.0 1.0 0.0 0 0 0 0 0 GO:1903540 7 establishment of protein localization to postsynaptic membrane 3 3 1 1 1 0 0 0 68 3 2476 0.922 1.0 1.0 0.0 0 0 0 0 0 GO:1903587 8 regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis 4 4 2 2 0 2 0 0 68 4 2475 0.89735 1.0 1.0 0.0 0 0 0 0 0 GO:1903589 9 positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis 4 4 2 2 0 2 0 0 68 4 2475 0.89735 1.0 1.0 0.0 0 0 0 0 0 GO:1903613 8 regulation of protein tyrosine phosphatase activity 3 4 1 1 1 0 0 0 68 4 2475 0.89735 1.0 1.0 0.0 0 0 0 0 0 GO:1903615 9 positive regulation of protein tyrosine phosphatase activity 2 3 1 1 1 0 0 0 68 3 2476 0.922 1.0 1.0 0.0 0 0 0 0 0 GO:1903707 6 negative regulation of hemopoiesis 45 48 1 1 0 1 0 0 68 48 2431 0.26949 1.0 0.63832 0.0 0 0 0 0 0 GO:1903708 6 positive regulation of hemopoiesis 72 78 4 4 1 1 0 0 68 78 2401 0.11721 1.0 0.27011 0.0 0 0 0 0 0 GO:1903726 7 negative regulation of phospholipid metabolic process 4 4 1 1 0 1 0 0 68 4 2475 0.89735 1.0 1.0 0.0 0 0 0 0 0 GO:1903789 8 regulation of amino acid transmembrane transport 3 4 1 0 0 0 0 0 68 4 2475 0.89735 1.0 1.0 0.0 0 0 0 0 0 GO:1903792 7 negative regulation of anion transport 7 8 1 0 0 0 0 0 68 8 2471 0.8051 1.0 1.0 0.0 0 0 0 0 0 GO:1903867 4 extraembryonic membrane development 1 1 1 0 0 1 0 0 68 1 2478 0.9733 1.0 1.0 0.0 0 0 0 0 0 GO:1903960 8 negative regulation of anion transmembrane transport 3 4 1 0 0 0 0 0 68 4 2475 0.89735 1.0 1.0 0.0 0 0 0 0 0 GO:1904030 8 negative regulation of cyclin-dependent protein kinase activity 8 8 1 1 1 0 0 0 68 8 2471 0.8051 1.0 1.0 0.0 0 0 0 0 0 GO:1904037 9 positive regulation of epithelial cell apoptotic process 14 16 1 1 0 1 0 0 68 16 2463 0.64774 1.0 1.0 0.0 0 0 0 0 0 GO:1904181 5 positive regulation of membrane depolarization 4 4 1 1 0 1 0 0 68 4 2475 0.89735 1.0 1.0 0.0 0 0 0 0 0 GO:1904235 7 regulation of substrate-dependent cell migration, cell attachment to substrate 1 1 1 1 0 0 0 0 68 1 2478 0.9733 1.0 1.0 0.0 0 0 0 0 0 GO:1904237 8 positive regulation of substrate-dependent cell migration, cell attachment to substrate 1 1 1 1 0 0 0 0 68 1 2478 0.9733 1.0 1.0 0.0 0 0 0 0 0 GO:1904338 9 regulation of dopaminergic neuron differentiation 3 3 1 1 1 0 0 0 68 3 2476 0.922 1.0 1.0 0.0 0 0 0 0 0 GO:1904340 9 positive regulation of dopaminergic neuron differentiation 1 1 1 1 1 0 0 0 68 1 2478 0.9733 1.0 1.0 0.0 0 0 0 0 0 GO:1904375 7 regulation of protein localization to cell periphery 35 37 1 1 1 0 0 0 68 37 2442 0.36477 1.0 0.62433 0.0 0 0 0 0 0 GO:1904385 7 cellular response to angiotensin 13 13 1 1 0 0 0 0 68 13 2466 0.70283 1.0 1.0 0.0 0 0 0 0 0 GO:1904486 5 response to 17alpha-ethynylestradiol 6 6 1 1 1 0 0 0 68 6 2473 0.84999 1.0 1.0 0.0 0 0 0 0 0 GO:1904646 7 cellular response to amyloid-beta 23 24 1 1 0 0 0 0 68 24 2455 0.52077 1.0 1.0 0.0 0 0 0 0 0 GO:1904666 9 regulation of ubiquitin protein ligase activity 6 6 1 1 1 0 0 0 68 6 2473 0.84999 1.0 1.0 0.0 0 0 0 0 0 GO:1904668 10 positive regulation of ubiquitin protein ligase activity 3 3 1 1 1 0 0 0 68 3 2476 0.922 1.0 1.0 0.0 0 0 0 0 0 GO:1904776 8 regulation of protein localization to cell cortex 4 4 1 1 1 0 0 0 68 4 2475 0.89735 1.0 1.0 0.0 0 0 0 0 0 GO:1904783 7 positive regulation of NMDA glutamate receptor activity 5 5 1 1 0 1 0 0 68 5 2474 0.87336 1.0 1.0 0.0 0 0 0 0 0 GO:1904950 5 negative regulation of establishment of protein localization 48 52 2 2 0 1 0 0 68 52 2427 0.24132 1.0 0.40137 0.0 0 0 0 0 0 GO:1904956 10 regulation of midbrain dopaminergic neuron differentiation 1 1 1 1 1 0 0 0 68 1 2478 0.9733 1.0 1.0 0.0 0 0 0 0 0 GO:1904958 10 positive regulation of midbrain dopaminergic neuron differentiation 1 1 1 1 1 0 0 0 68 1 2478 0.9733 1.0 1.0 0.0 0 0 0 0 0 GO:1905037 7 autophagosome organization 13 13 1 1 1 0 0 0 68 13 2466 0.70283 1.0 1.0 0.0 0 0 0 0 0 GO:1905207 6 regulation of cardiocyte differentiation 23 24 1 0 0 0 0 0 68 24 2455 0.52077 1.0 1.0 0.0 0 0 0 0 0 GO:1905208 6 negative regulation of cardiocyte differentiation 9 9 1 0 0 0 0 0 68 9 2470 0.78354 1.0 1.0 0.0 0 0 0 0 0 GO:1905267 9 endonucleolytic cleavage involved in tRNA processing 1 1 1 1 0 1 0 0 68 1 2478 0.9733 1.0 1.0 0.0 0 0 0 0 0 GO:1905332 6 positive regulation of morphogenesis of an epithelium 13 14 1 1 0 1 0 0 68 14 2465 0.68397 1.0 1.0 0.0 0 0 0 0 0 GO:1905424 8 regulation of Wnt-mediated midbrain dopaminergic neuron differentiation 1 1 1 1 1 0 0 0 68 1 2478 0.9733 1.0 1.0 0.0 0 0 0 0 0 GO:1905426 8 positive regulation of Wnt-mediated midbrain dopaminergic neuron differentiation 1 1 1 1 1 0 0 0 68 1 2478 0.9733 1.0 1.0 0.0 0 0 0 0 0 GO:1905449 6 regulation of Fc-gamma receptor signaling pathway involved in phagocytosis 1 2 1 1 1 0 0 0 68 2 2477 0.94731 1.0 1.0 0.0 0 0 0 0 0 GO:1905451 7 positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis 1 1 1 1 1 0 0 0 68 1 2478 0.9733 1.0 1.0 0.0 0 0 0 0 0 GO:1905475 7 regulation of protein localization to membrane 44 49 1 1 0 1 0 0 68 49 2430 0.26216 1.0 0.64068 0.0 0 0 0 0 0 GO:1905477 7 positive regulation of protein localization to membrane 26 30 1 1 0 1 0 0 68 30 2449 0.44195 1.0 1.0 0.0 0 0 0 0 0 GO:1905517 7 macrophage migration 4 4 1 1 0 1 0 0 68 4 2475 0.89735 1.0 1.0 0.0 0 0 0 0 0 GO:1905521 6 regulation of macrophage migration 13 14 1 1 0 1 0 0 68 14 2465 0.68397 1.0 1.0 0.0 0 0 0 0 0 GO:1905523 7 positive regulation of macrophage migration 9 9 1 1 0 1 0 0 68 9 2470 0.78354 1.0 1.0 0.0 0 0 0 0 0 GO:1905562 8 regulation of vascular endothelial cell proliferation 6 6 1 1 0 1 0 0 68 6 2473 0.84999 1.0 1.0 0.0 0 0 0 0 0 GO:1905563 9 negative regulation of vascular endothelial cell proliferation 3 3 1 1 0 1 0 0 68 3 2476 0.922 1.0 1.0 0.0 0 0 0 0 0 GO:1905664 6 regulation of calcium ion import across plasma membrane 3 3 1 1 0 1 0 0 68 3 2476 0.922 1.0 1.0 0.0 0 0 0 0 0 GO:1905665 11 positive regulation of calcium ion import across plasma membrane 2 2 1 1 0 1 0 0 68 2 2477 0.94731 1.0 1.0 0.0 0 0 0 0 0 GO:1990001 10 inhibition of cysteine-type endopeptidase activity involved in apoptotic process 4 4 1 1 0 0 0 0 68 4 2475 0.89735 1.0 1.0 0.0 0 0 0 0 0 GO:1990089 4 response to nerve growth factor 24 25 1 1 1 0 0 0 68 25 2454 0.50673 1.0 1.0 0.0 0 0 0 0 0 GO:1990090 6 cellular response to nerve growth factor stimulus 22 23 1 1 1 0 0 0 68 23 2456 0.53518 1.0 1.0 0.0 0 0 0 0 0 GO:1990126 5 retrograde transport, endosome to plasma membrane 2 2 1 1 1 0 0 0 68 2 2477 0.94731 1.0 1.0 0.0 0 0 0 0 0 GO:1990264 9 peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity 5 5 1 1 1 0 0 0 68 5 2474 0.87336 1.0 1.0 0.0 0 0 0 0 0 GO:1990401 6 embryonic lung development 1 1 1 1 0 1 0 0 68 1 2478 0.9733 1.0 1.0 0.0 0 0 0 0 0 GO:1990441 10 negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress 4 4 1 1 0 0 0 0 68 4 2475 0.89735 1.0 1.0 0.0 0 0 0 0 0 GO:1990511 9 piRNA biosynthetic process 1 1 1 1 0 1 0 0 68 1 2478 0.9733 1.0 1.0 0.0 0 0 0 0 0 GO:1990776 6 response to angiotensin 20 20 3 3 1 1 0 0 68 20 2459 0.58084 1.0 1.0 0.0 0 0 0 0 0 GO:1990778 6 protein localization to cell periphery 38 42 2 2 1 1 0 0 68 42 2437 0.31793 1.0 0.62756 0.0 0 0 0 0 0 GO:1990823 6 response to leukemia inhibitory factor 27 33 1 1 0 0 0 0 68 33 2446 0.40708 1.0 1.0 0.0 0 0 0 0 0 GO:1990830 7 cellular response to leukemia inhibitory factor 26 32 1 1 0 0 0 0 68 32 2447 0.41839 1.0 1.0 0.0 0 0 0 0 0 GO:2000027 6 regulation of animal organ morphogenesis 54 58 3 3 0 2 0 0 68 58 2421 0.20441 1.0 0.40481 0.0 0 0 0 0 0 GO:2000047 7 regulation of cell-cell adhesion mediated by cadherin 5 5 1 0 0 0 0 0 68 5 2474 0.87336 1.0 1.0 0.0 0 0 0 0 0 GO:2000048 8 negative regulation of cell-cell adhesion mediated by cadherin 4 4 1 0 0 0 0 0 68 4 2475 0.89735 1.0 1.0 0.0 0 0 0 0 0 GO:2000050 7 regulation of non-canonical Wnt signaling pathway 3 4 1 1 1 0 0 0 68 4 2475 0.89735 1.0 1.0 0.0 0 0 0 0 0 GO:2000052 8 positive regulation of non-canonical Wnt signaling pathway 2 3 1 1 1 0 0 0 68 3 2476 0.922 1.0 1.0 0.0 0 0 0 0 0 GO:2000134 9 negative regulation of G1/S transition of mitotic cell cycle 18 18 2 2 0 1 0 0 68 18 2461 0.61339 1.0 1.0 0.0 0 0 0 0 0 GO:2000142 8 regulation of DNA-templated transcription, initiation 10 12 1 1 0 0 0 0 68 12 2467 0.72221 1.0 1.0 0.0 0 0 0 0 0 GO:2000144 9 positive regulation of DNA-templated transcription, initiation 9 10 1 1 0 0 0 0 68 10 2469 0.76254 1.0 1.0 0.0 0 0 0 0 0 GO:2000273 5 positive regulation of signaling receptor activity 8 9 1 1 0 1 0 0 68 9 2470 0.78354 1.0 1.0 0.0 0 0 0 0 0 GO:2000278 7 regulation of DNA biosynthetic process 42 46 2 2 0 1 0 0 68 46 2433 0.28477 1.0 0.63404 0.0 0 0 0 0 0 GO:2000310 7 regulation of NMDA receptor activity 10 10 1 1 0 1 0 0 68 10 2469 0.76254 1.0 1.0 0.0 0 0 0 0 0 GO:2000353 10 positive regulation of endothelial cell apoptotic process 8 10 1 1 0 1 0 0 68 10 2469 0.76254 1.0 1.0 0.0 0 0 0 0 0 GO:2000378 7 negative regulation of reactive oxygen species metabolic process 32 33 1 1 0 0 0 0 68 33 2446 0.40708 1.0 1.0 0.0 0 0 0 0 0 GO:2000402 7 negative regulation of lymphocyte migration 3 3 1 1 0 1 0 0 68 3 2476 0.922 1.0 1.0 0.0 0 0 0 0 0 GO:2000471 7 regulation of hematopoietic stem cell migration 1 1 1 1 1 0 0 0 68 1 2478 0.9733 1.0 1.0 0.0 0 0 0 0 0 GO:2000473 8 positive regulation of hematopoietic stem cell migration 1 1 1 1 1 0 0 0 68 1 2478 0.9733 1.0 1.0 0.0 0 0 0 0 0 GO:2000501 8 regulation of natural killer cell chemotaxis 5 5 2 2 1 1 0 0 68 5 2474 0.87336 1.0 1.0 0.0 0 0 0 0 0 GO:2000502 9 negative regulation of natural killer cell chemotaxis 1 1 1 1 0 1 0 0 68 1 2478 0.9733 1.0 1.0 0.0 0 0 0 0 0 GO:2000503 9 positive regulation of natural killer cell chemotaxis 4 4 1 1 1 0 0 0 68 4 2475 0.89735 1.0 1.0 0.0 0 0 0 0 0 GO:2000573 8 positive regulation of DNA biosynthetic process 29 33 1 1 0 0 0 0 68 33 2446 0.40708 1.0 1.0 0.0 0 0 0 0 0 GO:2000589 7 regulation of metanephric mesenchymal cell migration 3 3 1 1 0 1 0 0 68 3 2476 0.922 1.0 1.0 0.0 0 0 0 0 0 GO:2000591 8 positive regulation of metanephric mesenchymal cell migration 2 2 1 1 0 1 0 0 68 2 2477 0.94731 1.0 1.0 0.0 0 0 0 0 0 GO:2000648 7 positive regulation of stem cell proliferation 13 14 1 1 1 0 0 0 68 14 2465 0.68397 1.0 1.0 0.0 0 0 0 0 0 GO:2000725 7 regulation of cardiac muscle cell differentiation 21 22 1 0 0 0 0 0 68 22 2457 0.55 1.0 1.0 0.0 0 0 0 0 0 GO:2000726 7 negative regulation of cardiac muscle cell differentiation 8 8 1 0 0 0 0 0 68 8 2471 0.8051 1.0 1.0 0.0 0 0 0 0 0 GO:2000756 9 regulation of peptidyl-lysine acetylation 20 20 1 1 0 0 0 0 68 20 2459 0.58084 1.0 1.0 0.0 0 0 0 0 0 GO:2000758 10 positive regulation of peptidyl-lysine acetylation 12 12 1 1 0 0 0 0 68 12 2467 0.72221 1.0 1.0 0.0 0 0 0 0 0 GO:2000759 8 regulation of N-terminal peptidyl-lysine acetylation 1 1 1 1 0 0 0 0 68 1 2478 0.9733 1.0 1.0 0.0 0 0 0 0 0 GO:2000761 9 positive regulation of N-terminal peptidyl-lysine acetylation 1 1 1 1 0 0 0 0 68 1 2478 0.9733 1.0 1.0 0.0 0 0 0 0 0 GO:2000831 6 regulation of steroid hormone secretion 7 7 2 1 0 1 0 0 68 7 2472 0.82725 1.0 1.0 0.0 0 0 0 0 0 GO:2000833 6 positive regulation of steroid hormone secretion 3 3 1 0 0 0 0 0 68 3 2476 0.922 1.0 1.0 0.0 0 0 0 0 0 GO:2000846 7 regulation of corticosteroid hormone secretion 4 4 2 1 0 1 0 0 68 4 2475 0.89735 1.0 1.0 0.0 0 0 0 0 0 GO:2000848 7 positive regulation of corticosteroid hormone secretion 2 2 1 0 0 0 0 0 68 2 2477 0.94731 1.0 1.0 0.0 0 0 0 0 0 GO:2000855 8 regulation of mineralocorticoid secretion 3 3 2 1 0 1 0 0 68 3 2476 0.922 1.0 1.0 0.0 0 0 0 0 0 GO:2000857 8 positive regulation of mineralocorticoid secretion 2 2 1 0 0 0 0 0 68 2 2477 0.94731 1.0 1.0 0.0 0 0 0 0 0 GO:2000858 9 regulation of aldosterone secretion 3 3 2 1 0 1 0 0 68 3 2476 0.922 1.0 1.0 0.0 0 0 0 0 0 GO:2000860 9 positive regulation of aldosterone secretion 2 2 1 0 0 0 0 0 68 2 2477 0.94731 1.0 1.0 0.0 0 0 0 0 0 GO:2000864 6 regulation of estradiol secretion 4 5 1 1 0 0 0 0 68 5 2474 0.87336 1.0 1.0 0.0 0 0 0 0 0 GO:2000866 7 positive regulation of estradiol secretion 3 4 1 1 0 0 0 0 68 4 2475 0.89735 1.0 1.0 0.0 0 0 0 0 0 GO:2001024 6 negative regulation of response to drug 20 22 2 1 0 0 0 0 68 22 2457 0.55 1.0 1.0 0.0 0 0 0 0 0 GO:2001038 5 regulation of cellular response to drug 20 23 1 1 0 0 0 0 68 23 2456 0.53518 1.0 1.0 0.0 0 0 0 0 0 GO:2001039 6 negative regulation of cellular response to drug 15 16 1 1 0 0 0 0 68 16 2463 0.64774 1.0 1.0 0.0 0 0 0 0 0 GO:2001198 7 regulation of dendritic cell differentiation 5 5 1 1 0 1 0 0 68 5 2474 0.87336 1.0 1.0 0.0 0 0 0 0 0 GO:2001199 8 negative regulation of dendritic cell differentiation 2 2 1 1 0 1 0 0 68 2 2477 0.94731 1.0 1.0 0.0 0 0 0 0 0 GO:2001201 7 regulation of transforming growth factor-beta secretion 1 1 1 1 0 0 0 0 68 1 2478 0.9733 1.0 1.0 0.0 0 0 0 0 0 GO:2001202 7 negative regulation of transforming growth factor-beta secretion 1 1 1 1 0 0 0 0 68 1 2478 0.9733 1.0 1.0 0.0 0 0 0 0 0 GO:2001238 8 positive regulation of extrinsic apoptotic signaling pathway 16 17 1 1 1 0 0 0 68 17 2462 0.63033 1.0 1.0 0.0 0 0 0 0 0 GO:2001279 8 regulation of unsaturated fatty acid biosynthetic process 5 6 1 1 1 0 0 0 68 6 2473 0.84999 1.0 1.0 0.0 0 0 0 0 0 GO:2001280 9 positive regulation of unsaturated fatty acid biosynthetic process 5 6 1 1 1 0 0 0 68 6 2473 0.84999 1.0 1.0 0.0 0 0 0 0 0 GO:0048468 4 cell development 159 163 10 9 7 4 4 4 64 159 2320 0.55747 0.64319 1.0 2.45 24832;24426;24646;170913 thy1;gstp1;abcb1b;abcb1a THY1_33010;GSTP1_8762;ABCB1B_7939;ABCB1A_7938 60.634800000001434 17.7786 5.72311E-12 97.95505118209289 69.70245359838597 100.08941497184317 33.92711750000143 8.841735 5.72311E-12 56.22202384704559 38.34204898016585 58.01194804034109 403.6202750000014 41.46555 5.72313E-12 752.3170321285442 462.6812849218895 777.16442893302 5.72311E-12;14.7631;20.7941;206.982 5.72311E-12;9.42992;8.25355;118.025 5.72313E-12;25.7196;57.2115;1531.55 1 3 1 24426 GSTP1_8762 14.7631 14.7631 9.42992 9.42992 25.7196 25.7196 14.7631 9.42992 25.7196 3 24832;24646;170913 THY1_33010;ABCB1B_7939;ABCB1A_7938 75.92536666666858 20.7941 113.97359125781244 42.09285000000191 8.25355 65.88853333181169 529.5871666666686 57.2115 868.1966531086608 5.72311E-12;20.7941;206.982 5.72311E-12;8.25355;118.025 5.72313E-12;57.2115;1531.55 0 Exp 4,1(0.25);Hill,2(0.5);Poly 2,1(0.25) 2.9604911553515487 13.469875574111938 1.863204002380371 6.191005229949951 2.0372677124767486 2.707833170890808 -35.361150158449576 156.63075015845243 -21.170465870103243 89.0247008701061 -333.6504164859719 1140.8909664859748 DOWN 0.25 0.75 0.0 GO:0009628 3 response to abiotic stimulus 422 443 36 35 26 26 20 20 48 423 2056 0.99588 0.0092151 0.013772 4.51 116669;360243;25682;362282;300795;24314;81687;291234;25283;361921;24296;245920;84032;24854;114494;686019;246142;25612;24646;170913 vwf;top2a;ppard;pck1;pclaf;nqo1;mmp9;mki67;gclc;ect2;cyp1a1;cxcl10;col3a1;clu;ccna2;casq1;bmf;asns;abcb1b;abcb1a VWF_32396;TOP2A_10059;PPARD_9536;PCK1_9439;NS5ATP9_9367;NQO1_33055;MMP9_32531;MKI67_9232;GCLC_8699;ECT2_8523;CYP1A1_8415;CXCL10_8408;COL3A1_8354;CLU_32773;CCNA2_8221;CASQ1_32992;BMF_8152;ASNS_8091;ABCB1B_7939;ABCB1A_7938 223.56545500000001 125.5505 10.0162 273.1960577267493 167.80525914839205 237.54365635594348 140.4639035 60.87219999999999 3.29405 205.99797581971748 102.47678157473901 178.18719456371838 602.009515 274.023 19.3234 674.8656905358858 470.6314061199467 613.2462666194091 19.6764;86.3883;94.1074;529.244;292.216;25.6813;728.316;21.9311;131.7;10.0162;12.8863;670.528;212.603;935.649;14.384;147.66;119.401;191.145;20.7941;206.982 4.11644;26.6888;37.7692;356.883;147.515;7.73944;443.137;6.82654;39.9158;3.29405;9.13136;374.802;119.81;808.484;4.89199;96.6023;81.8286;113.564;8.25355;118.025 94.078;262.273;148.485;1021.06;658.494;86.1211;2039.06;76.1794;397.209;37.7305;19.3234;1955.3;1510.69;1071.05;58.2504;285.773;220.085;510.267;57.2115;1531.55 3 17 3 362282;24314;24296 PCK1_9439;NQO1_33055;CYP1A1_8415 189.27053333333333 25.6813 294.49515536637165 124.58459999999998 9.13136 201.1775194753171 375.5015 86.1211 560.0667959029618 529.244;25.6813;12.8863 356.883;7.73944;9.13136 1021.06;86.1211;19.3234 17 116669;360243;25682;300795;81687;291234;25283;361921;245920;84032;24854;114494;686019;246142;25612;24646;170913 VWF_32396;TOP2A_10059;PPARD_9536;NS5ATP9_9367;MMP9_32531;MKI67_9232;GCLC_8699;ECT2_8523;CXCL10_8408;COL3A1_8354;CLU_32773;CCNA2_8221;CASQ1_32992;BMF_8152;ASNS_8091;ABCB1B_7939;ABCB1A_7938 229.6175 131.7 278.44206667846765 143.26613352941175 81.8286 212.7841360522204 641.9815176470588 285.773 700.2232275200649 19.6764;86.3883;94.1074;292.216;728.316;21.9311;131.7;10.0162;670.528;212.603;935.649;14.384;147.66;119.401;191.145;20.7941;206.982 4.11644;26.6888;37.7692;147.515;443.137;6.82654;39.9158;3.29405;374.802;119.81;808.484;4.89199;96.6023;81.8286;113.564;8.25355;118.025 94.078;262.273;148.485;658.494;2039.06;76.1794;397.209;37.7305;1955.3;1510.69;1071.05;58.2504;285.773;220.085;510.267;57.2115;1531.55 0 Exp 2,2(0.1);Exp 4,5(0.25);Exp 5,1(0.05);Hill,4(0.2);Linear,2(0.1);Poly 2,6(0.3) 2.171707230931826 54.974743723869324 1.5548590421676636 15.48720932006836 3.1583515891386953 1.9047590494155884 103.8320035726543 343.2989064273458 50.18130997659169 230.7464970234082 306.23658529476694 897.7824447052333 DOWN 0.15 0.85 0.0 GO:0043086 5 negative regulation of catalytic activity 212 228 16 14 11 7 6 6 62 222 2257 0.59176 0.57857 1.0 2.63 24832;295703;24314;81687;24426;24232 thy1;serping1;nqo1;mmp9;gstp1;c3 THY1_33010;SERPING1_32597;NQO1_33055;MMP9_32531;GSTP1_8762;C3_8175 172.65318333333428 29.0405 5.72311E-12 285.87706186316746 222.17884806154157 333.453816822722 100.53086000000094 11.580359999999999 5.72311E-12 174.784576545141 131.0523804676803 204.8856968646703 490.76753333333426 92.8048 5.72313E-12 801.5686135238963 628.5754177350843 931.7390318915614 5.72311E-12;32.3997;25.6813;728.316;14.7631;234.759 5.72311E-12;13.7308;7.73944;443.137;9.42992;129.148 5.72313E-12;99.4885;86.1211;2039.06;25.7196;694.216 2 4 2 24314;24426 NQO1_33055;GSTP1_8762 20.2222 20.2222 7.720333258350962 8.584679999999999 8.584679999999999 1.1953498714602508 55.92035 55.92035 42.710310243839245 25.6813;14.7631 7.73944;9.42992 86.1211;25.7196 4 24832;295703;81687;24232 THY1_33010;SERPING1_32597;MMP9_32531;C3_8175 248.86867500000142 133.57935 336.08692075714816 146.50395000000142 71.43939999999999 206.06189367859704 708.1911250000014 396.85225 938.697825318524 5.72311E-12;32.3997;728.316;234.759 5.72311E-12;13.7308;443.137;129.148 5.72313E-12;99.4885;2039.06;694.216 0 Exp 4,2(0.34);Hill,2(0.34);Linear,1(0.17);Poly 2,1(0.17) 2.066484727447904 12.880596041679382 1.5467612743377686 3.5281898975372314 0.7130350528102017 1.9572752714157104 -56.096107372067195 401.40247403873576 -39.32592896504693 240.38764896504884 -150.6209383414802 1132.1560050081487 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0050789 3 regulation of biological process 1644 1779 107 104 70 66 47 47 21 1732 747 0.4937 0.61106 0.89388 2.64 684352;315852;688621;360243;24832;25671;295703;25682;363131;25154;362282;304545;300795;338475;259241;24314;316351;81687;291234;24426;156275;25283;81919;24367;309186;29243;361921;64191;312495;24296;245920;84032;24854;306575;170945;113902;114494;29397;686019;24232;246142;25612;29657;29221;81639;252898;170913 twf2;ttk;tslp;top2a;thy1;smad1;serping1;ppard;pik3r4;pgr;pck1;oasl;pclaf;nrep;nr1d2;nqo1;npas2;mmp9;mki67;gstp1;ggt7;gclc;fut1;fgg;fermt3;f10;ect2;dhcr7;cyp26b1;cyp1a1;cxcl10;col3a1;clu;ckap2;chrna2;ces1d;ccna2;ccl11;casq1;c3;bmf;asns;arntl;arg1;alox15;acox2;abcb1a TWF2_10109;TTK_32727;TSLP_32811;TOP2A_10059;THY1_33010;SMAD1_32578;SERPING1_32597;PPARD_9536;PIK3R4_9484;PGR_32824;PCK1_9439;OASL_9389;NS5ATP9_9367;NREP_9364;NR1D2_9358;NQO1_33055;NPAS2_9350;MMP9_32531;MKI67_9232;GSTP1_8762;GGT7_33026;GCLC_8699;FUT1_8668;FGG_8639;FERMT3_32542;F10_8585;ECT2_8523;DHCR7_8466;CYP26B1_8418;CYP1A1_8415;CXCL10_8408;COL3A1_8354;CLU_32773;CKAP2_8324;CHRNA2_32401;CES1D_32914;CCNA2_8221;CCL11_33230;CASQ1_32992;C3_8175;BMF_8152;ASNS_8091;ARNTL_8086;ARG1_33267;ALOX15_8036;ACOX2_32902;ABCB1A_7938 257.15410000000014 131.7 5.72311E-12 301.1911566422342 230.644048187054 278.9035581217442 153.06567361702142 50.9087 5.72311E-12 204.34206439774155 132.70214222217726 184.34922823321995 695.8765042553193 299.165 5.72313E-12 802.5037781157464 642.1345261027292 778.1007895149575 138.399;737.351;344.675;86.3883;5.72311E-12;21.9973;32.3997;94.1074;955.628;283.618;529.244;76.6126;292.216;61.543;29.1728;25.6813;21.0878;728.316;21.9311;14.7631;109.609;131.7;240.861;42.4612;539.113;104.19;10.0162;161.702;18.1872;12.8863;670.528;212.603;935.649;32.2386;163.479;11.0684;14.384;986.476;147.66;234.759;119.401;191.145;22.9134;760.927;766.819;743.353;206.982 90.7363;446.625;244.2;26.6888;5.72311E-12;5.02186;13.7308;37.7692;735.228;138.711;356.883;28.4477;147.515;25.6719;3.35457;7.73944;11.3305;443.137;6.82654;9.42992;29.3336;39.9158;78.9726;20.6424;334.248;38.4229;3.29405;50.9087;10.0176;9.13136;374.802;119.81;808.484;15.2683;101.968;4.18343;4.89199;552.974;96.6023;129.148;81.8286;113.564;11.4115;413.607;421.048;432.537;118.025 299.165;2108.09;560.435;262.273;5.72313E-12;80.1461;99.4885;148.485;1288.97;1554.21;1021.06;260.389;658.494;148.788;114.038;86.1211;43.5624;2039.06;76.1794;25.7196;346.073;397.209;847.87;98.0534;1187.86;163.044;37.7305;481.517;36.7271;19.3234;1955.3;1510.69;1071.05;76.7052;414.362;17.0564;58.2504;2230.86;285.773;694.216;220.085;510.267;50.1592;2639.93;2662.07;2287.79;1531.55 7 40 7 362282;259241;24314;24426;312495;24296;29397 PCK1_9439;NR1D2_9358;NQO1_33055;GSTP1_8762;CYP26B1_8418;CYP1A1_8415;CCL11_33230 230.91581428571428 25.6813 383.4502746171983 135.64712714285716 9.42992 225.3473349291568 504.8356 86.1211 842.4262838970759 529.244;29.1728;25.6813;14.7631;18.1872;12.8863;986.476 356.883;3.35457;7.73944;9.42992;10.0176;9.13136;552.974 1021.06;114.038;86.1211;25.7196;36.7271;19.3234;2230.86 40 684352;315852;688621;360243;24832;25671;295703;25682;363131;25154;304545;300795;338475;316351;81687;291234;156275;25283;81919;24367;309186;29243;361921;64191;245920;84032;24854;306575;170945;113902;114494;686019;24232;246142;25612;29657;29221;81639;252898;170913 TWF2_10109;TTK_32727;TSLP_32811;TOP2A_10059;THY1_33010;SMAD1_32578;SERPING1_32597;PPARD_9536;PIK3R4_9484;PGR_32824;OASL_9389;NS5ATP9_9367;NREP_9364;NPAS2_9350;MMP9_32531;MKI67_9232;GGT7_33026;GCLC_8699;FUT1_8668;FGG_8639;FERMT3_32542;F10_8585;ECT2_8523;DHCR7_8466;CXCL10_8408;COL3A1_8354;CLU_32773;CKAP2_8324;CHRNA2_32401;CES1D_32914;CCNA2_8221;CASQ1_32992;C3_8175;BMF_8152;ASNS_8091;ARNTL_8086;ARG1_33267;ALOX15_8036;ACOX2_32902;ABCB1A_7938 261.74580000000014 143.02949999999998 290.228646829384 156.11391925000015 80.4006 203.40544369355496 729.3086625000002 371.64099999999996 801.7015465238668 138.399;737.351;344.675;86.3883;5.72311E-12;21.9973;32.3997;94.1074;955.628;283.618;76.6126;292.216;61.543;21.0878;728.316;21.9311;109.609;131.7;240.861;42.4612;539.113;104.19;10.0162;161.702;670.528;212.603;935.649;32.2386;163.479;11.0684;14.384;147.66;234.759;119.401;191.145;22.9134;760.927;766.819;743.353;206.982 90.7363;446.625;244.2;26.6888;5.72311E-12;5.02186;13.7308;37.7692;735.228;138.711;28.4477;147.515;25.6719;11.3305;443.137;6.82654;29.3336;39.9158;78.9726;20.6424;334.248;38.4229;3.29405;50.9087;374.802;119.81;808.484;15.2683;101.968;4.18343;4.89199;96.6023;129.148;81.8286;113.564;11.4115;413.607;421.048;432.537;118.025 299.165;2108.09;560.435;262.273;5.72313E-12;80.1461;99.4885;148.485;1288.97;1554.21;260.389;658.494;148.788;43.5624;2039.06;76.1794;346.073;397.209;847.87;98.0534;1187.86;163.044;37.7305;481.517;1955.3;1510.69;1071.05;76.7052;414.362;17.0564;58.2504;285.773;694.216;220.085;510.267;50.1592;2639.93;2662.07;2287.79;1531.55 0 Exp 2,8(0.18);Exp 4,18(0.39);Exp 5,3(0.07);Hill,3(0.07);Linear,3(0.07);Poly 2,11(0.24);Power,1(0.03) 1.9646338043233837 104.03968012332916 1.5018656253814697 15.48720932006836 2.034672427358428 1.7986326217651367 171.0449388143935 343.2632611856068 94.64522078438534 211.48612644965743 466.4443789824312 925.3086295282072 DOWN 0.14893617021276595 0.851063829787234 0.0 GO:0030242 5 autophagy of peroxisome 2 2 1 1 1 1 1 1 67 1 2478 0.9993 0.052694 0.052694 50.0 363131 pik3r4 PIK3R4_9484 955.628 955.628 955.628 955.628 735.228 735.228 735.228 735.228 1288.97 1288.97 1288.97 1288.97 0.0 955.628 0.0 955.628 955.628 735.228 1288.97 0 1 0 1 363131 PIK3R4_9484 955.628 955.628 735.228 735.228 1288.97 1288.97 955.628 735.228 1288.97 0 Poly 2,1(1) 1.5018656253814697 1.5018656253814697 1.5018656253814697 1.5018656253814697 0.0 1.5018656253814697 955.628 955.628 735.228 735.228 1288.97 1288.97 DOWN 0.0 1.0 0.0 GO:0032869 7 cellular response to insulin stimulus 59 62 5 5 3 5 3 3 65 59 2420 0.91845 0.22854 0.22854 4.84 362282;24426;25283 pck1;gstp1;gclc PCK1_9439;GSTP1_8762;GCLC_8699 225.23570000000004 131.7 14.7631 269.6930560787021 140.2241492819292 164.3148972353519 135.40957333333333 39.9158 9.42992 192.40635711808 62.02731633207894 116.86509933101267 481.3295333333333 397.209 25.7196 502.97398149830104 364.7047223561938 321.5079467521673 529.244;14.7631;131.7 356.883;9.42992;39.9158 1021.06;25.7196;397.209 2 1 2 362282;24426 PCK1_9439;GSTP1_8762 272.00355 272.00355 363.7929331809581 183.15645999999998 183.15645999999998 245.686429012152 523.3897999999999 523.3897999999999 703.8119464289307 529.244;14.7631 356.883;9.42992 1021.06;25.7196 1 25283 GCLC_8699 131.7 131.7 39.9158 39.9158 397.209 397.209 131.7 39.9158 397.209 0 Exp 4,1(0.34);Hill,1(0.34);Linear,1(0.34) 2.239163505420341 7.114291548728943 1.611412525177002 3.5281898975372314 1.0181167280023655 1.9746891260147095 -79.95072271019859 530.4221227101987 -82.31871633546746 353.1378630021341 -87.83910734897381 1050.4981740156404 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0044282 4 small molecule catabolic process 107 120 7 7 7 7 7 7 61 113 2366 0.9868 0.038575 0.038575 5.83 25682;362282;312495;24296;113902;29221;252898 ppard;pck1;cyp26b1;cyp1a1;ces1d;arg1;acox2 PPARD_9536;PCK1_9439;CYP26B1_8418;CYP1A1_8415;CES1D_32914;ARG1_33267;ACOX2_32902 309.9676142857143 94.1074 11.0684 353.22298984187694 299.494734960327 366.894307841312 180.5897985714286 37.7692 4.18343 207.71113863204766 167.6959935874008 208.73680245970917 881.4817 148.485 17.0564 1142.4219951652206 924.2590284844113 1238.4089565893564 5.0 743.353 94.1074;529.244;18.1872;12.8863;11.0684;760.927;743.353 37.7692;356.883;10.0176;9.13136;4.18343;413.607;432.537 148.485;1021.06;36.7271;19.3234;17.0564;2639.93;2287.79 3 4 3 362282;312495;24296 PCK1_9439;CYP26B1_8418;CYP1A1_8415 186.7725 18.1872 296.6008616295476 125.34398666666665 10.0176 200.51915713184246 359.03683333333333 36.7271 573.394913733932 529.244;18.1872;12.8863 356.883;10.0176;9.13136 1021.06;36.7271;19.3234 4 25682;113902;29221;252898 PPARD_9536;CES1D_32914;ARG1_33267;ACOX2_32902 402.36395 418.73019999999997 405.3703249757806 222.0241575 225.68810000000002 232.68298485196956 1273.3153499999999 1218.1375 1383.259951807501 94.1074;11.0684;760.927;743.353 37.7692;4.18343;413.607;432.537 148.485;17.0564;2639.93;2287.79 0 Exp 2,2(0.29);Exp 4,2(0.29);Exp 5,2(0.29);Linear,1(0.15) 2.3377586358038744 25.800415873527527 1.513624906539917 15.48720932006836 5.208481017522328 1.6269687414169312 48.29636151347006 571.6388670579585 26.715233711059994 334.4643634317971 35.16364238072572 1727.7997576192743 CONFLICT 0.42857142857142855 0.5714285714285714 0.0 GO:0061402 9 positive regulation of transcription from RNA polymerase II promoter in response to acidic pH 2 2 1 1 1 1 1 1 67 1 2478 0.9993 0.052694 0.052694 50.0 362282 pck1 PCK1_9439 529.244 529.244 529.244 529.244 356.883 356.883 356.883 356.883 1021.06 1021.06 1021.06 1021.06 0.0 529.244 0.0 529.244 529.244 356.883 1021.06 1 0 1 362282 PCK1_9439 529.244 529.244 356.883 356.883 1021.06 1021.06 529.244 356.883 1021.06 0 0 Linear,1(1) 1.611412525177002 1.611412525177002 1.611412525177002 1.611412525177002 0.0 1.611412525177002 529.244 529.244 356.883 356.883 1021.06 1021.06 UP 1.0 0.0 0.0 GO:0032956 6 regulation of actin cytoskeleton organization 79 82 5 5 4 5 4 4 64 78 2401 0.93447 0.17362 0.27844 4.88 684352;361921;29397;81639 twf2;ect2;ccl11;alox15 TWF2_10109;ECT2_8523;CCL11_33230;ALOX15_8036 475.42755 452.609 10.0162 474.789589749828 469.68127489045827 485.90858476402775 267.0130875 255.89215000000002 3.29405 262.1206047464678 262.357889375741 269.676662084762 1307.4563750000002 1265.0125 37.7305 1331.228458009454 1304.6801094901798 1358.6875226346122 138.399;10.0162;986.476;766.819 90.7363;3.29405;552.974;421.048 299.165;37.7305;2230.86;2662.07 1 3 1 29397 CCL11_33230 986.476 986.476 552.974 552.974 2230.86 2230.86 986.476 552.974 2230.86 3 684352;361921;81639 TWF2_10109;ECT2_8523;ALOX15_8036 305.07806666666664 138.399 404.99883082623006 171.69278333333332 90.7363 220.32942343324424 999.6551666666668 299.165 1445.6155464066453 138.399;10.0162;766.819 90.7363;3.29405;421.048 299.165;37.7305;2662.07 0 Exp 2,1(0.25);Exp 4,1(0.25);Poly 2,1(0.25);Power,1(0.25) 1.7193159151960484 6.914117813110352 1.5021449327468872 1.9814788103103638 0.20671928330672018 1.7152470350265503 10.133752045168535 940.7213479548315 10.13489484846167 523.8912801515385 2.8524861507351034 2612.0602638492655 DOWN 0.25 0.75 0.0 GO:0051172 6 negative regulation of nitrogen compound metabolic process 471 499 27 24 17 13 11 11 57 488 1991 0.29352 0.80708 0.53846 2.2 24832;295703;25682;25154;259241;81687;24426;25283;24854;24232;29657 thy1;serping1;ppard;pgr;nr1d2;mmp9;gstp1;gclc;clu;c3;arntl THY1_33010;SERPING1_32597;PPARD_9536;PGR_32824;NR1D2_9358;MMP9_32531;GSTP1_8762;GCLC_8699;CLU_32773;C3_8175;ARNTL_8086 227.94530909090963 94.1074 5.72311E-12 316.0267963853392 267.8965014124168 333.86835346754935 148.64470818181871 37.7692 5.72311E-12 254.22975863679352 170.17365642880267 262.85693030856726 563.057754545455 148.485 5.72313E-12 701.4946069297739 652.2399652573278 755.5968045423148 5.72311E-12;32.3997;94.1074;283.618;29.1728;728.316;14.7631;131.7;935.649;234.759;22.9134 5.72311E-12;13.7308;37.7692;138.711;3.35457;443.137;9.42992;39.9158;808.484;129.148;11.4115 5.72313E-12;99.4885;148.485;1554.21;114.038;2039.06;25.7196;397.209;1071.05;694.216;50.1592 2 9 2 259241;24426 NR1D2_9358;GSTP1_8762 21.96795 21.96795 10.18919658486379 6.392244999999999 6.392244999999999 4.295921183081692 69.8788 69.8788 62.45053954354597 29.1728;14.7631 3.35457;9.42992 114.038;25.7196 9 24832;295703;25682;25154;81687;25283;24854;24232;29657 THY1_33010;SERPING1_32597;PPARD_9536;PGR_32824;MMP9_32531;GCLC_8699;CLU_32773;C3_8175;ARNTL_8086 273.7180555555562 131.7 334.46148822068795 180.2563666666673 39.9158 273.1400848681767 672.6530777777784 397.209 735.0591463739182 5.72311E-12;32.3997;94.1074;283.618;728.316;131.7;935.649;234.759;22.9134 5.72311E-12;13.7308;37.7692;138.711;443.137;39.9158;808.484;129.148;11.4115 5.72313E-12;99.4885;148.485;1554.21;2039.06;397.209;1071.05;694.216;50.1592 0 Exp 4,4(0.37);Exp 5,1(0.1);Hill,2(0.19);Linear,1(0.1);Poly 2,3(0.28) 2.0343460513382796 23.34220850467682 1.5405861139297485 3.5281898975372314 0.70758362707862 1.9388991594314575 41.18540706144597 414.70521112037324 -1.5954782803707417 298.88489464400817 148.50093353254096 977.6145755583689 DOWN 0.18181818181818182 0.8181818181818182 0.0 GO:1901575 4 organic substance catabolic process 296 332 17 17 13 15 12 12 56 320 2159 0.90373 0.16657 0.27081 3.61 25682;363131;362282;156275;312495;24296;113902;116599;29657;29221;26760;252898 ppard;pik3r4;pck1;ggt7;cyp26b1;cyp1a1;ces1d;blvra;arntl;arg1;akr7a3;acox2 PPARD_9536;PIK3R4_9484;PCK1_9439;GGT7_33026;CYP26B1_8418;CYP1A1_8415;CES1D_32914;BLVRA_8151;ARNTL_8086;ARG1_33267;AKR7A3_8015;ACOX2_32902 310.55600000000004 101.8582 11.0684 352.31879455656474 293.4684055823064 348.2031856919917 195.04647416666668 33.5514 4.18343 244.0773365261038 173.30650805190567 225.85353444125667 732.7835916666667 281.48 17.0564 913.3703799855173 790.7277191599336 1033.4273470907874 94.1074;955.628;529.244;109.609;18.1872;12.8863;11.0684;415.991;22.9134;760.927;52.7573;743.353 37.7692;735.228;356.883;29.3336;10.0176;9.13136;4.18343;288.048;11.4115;413.607;12.408;432.537 148.485;1288.97;1021.06;346.073;36.7271;19.3234;17.0564;720.942;50.1592;2639.93;216.887;2287.79 4 8 4 362282;312495;24296;26760 PCK1_9439;CYP26B1_8418;CYP1A1_8415;AKR7A3_8015 153.26870000000002 35.47225 251.27289123717 97.10999 11.2128 173.18753570143667 323.499375 126.80705 473.53929281859575 529.244;18.1872;12.8863;52.7573 356.883;10.0176;9.13136;12.408 1021.06;36.7271;19.3234;216.887 8 25682;363131;156275;113902;116599;29657;29221;252898 PPARD_9536;PIK3R4_9484;GGT7_33026;CES1D_32914;BLVRA_8151;ARNTL_8086;ARG1_33267;ACOX2_32902 389.19965 262.8 383.13815056263604 244.01471625 162.9086 269.3325377165534 937.4257 533.5074999999999 1035.0224397691427 94.1074;955.628;109.609;11.0684;415.991;22.9134;760.927;743.353 37.7692;735.228;29.3336;4.18343;288.048;11.4115;413.607;432.537 148.485;1288.97;346.073;17.0564;720.942;50.1592;2639.93;2287.79 0 Exp 2,3(0.25);Exp 4,4(0.34);Exp 5,2(0.17);Hill,1(0.09);Linear,1(0.09);Poly 2,1(0.09) 2.1414210813514325 35.80066788196564 1.5018656253814697 15.48720932006836 3.97464890655773 1.6191906332969666 111.21287613975869 509.89912386024116 56.946720539162385 333.14622779417095 215.99564960728674 1249.5715337260463 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0044248 4 cellular catabolic process 306 344 20 20 16 15 13 13 55 331 2148 0.93408 0.11896 0.20475 3.78 25682;363131;362282;156275;25315;312495;24296;113902;116599;29657;29221;26760;252898 ppard;pik3r4;pck1;ggt7;ephx1;cyp26b1;cyp1a1;ces1d;blvra;arntl;arg1;akr7a3;acox2 PPARD_9536;PIK3R4_9484;PCK1_9439;GGT7_33026;EPHX1_8567;CYP26B1_8418;CYP1A1_8415;CES1D_32914;BLVRA_8151;ARNTL_8086;ARG1_33267;AKR7A3_8015;ACOX2_32902 289.6853923076923 94.1074 11.0684 345.61113701978564 267.8289664669048 338.54097368770476 181.50126076923075 29.3336 4.18343 238.7350285001572 157.7403417049068 218.83150856580247 682.6999692307692 216.887 17.0564 892.9354942289508 719.2210483366761 1001.4906225607351 94.1074;955.628;529.244;109.609;39.2381;18.1872;12.8863;11.0684;415.991;22.9134;760.927;52.7573;743.353 37.7692;735.228;356.883;29.3336;18.9587;10.0176;9.13136;4.18343;288.048;11.4115;413.607;12.408;432.537 148.485;1288.97;1021.06;346.073;81.6965;36.7271;19.3234;17.0564;720.942;50.1592;2639.93;216.887;2287.79 5 8 5 362282;25315;312495;24296;26760 PCK1_9439;EPHX1_8567;CYP26B1_8418;CYP1A1_8415;AKR7A3_8015 130.46258 39.2381 223.50423922218343 81.479732 12.408 154.00313866114908 275.1388 81.6965 424.11475151662074 529.244;39.2381;18.1872;12.8863;52.7573 356.883;18.9587;10.0176;9.13136;12.408 1021.06;81.6965;36.7271;19.3234;216.887 8 25682;363131;156275;113902;116599;29657;29221;252898 PPARD_9536;PIK3R4_9484;GGT7_33026;CES1D_32914;BLVRA_8151;ARNTL_8086;ARG1_33267;ACOX2_32902 389.19965 262.8 383.13815056263604 244.01471625 162.9086 269.3325377165534 937.4257 533.5074999999999 1035.0224397691427 94.1074;955.628;109.609;11.0684;415.991;22.9134;760.927;743.353 37.7692;735.228;29.3336;4.18343;288.048;11.4115;413.607;432.537 148.485;1288.97;346.073;17.0564;720.942;50.1592;2639.93;2287.79 0 Exp 2,3(0.24);Exp 4,5(0.39);Exp 5,2(0.16);Hill,1(0.08);Linear,1(0.08);Poly 2,1(0.08) 2.1341206029330166 37.84909999370575 1.5018656253814697 15.48720932006836 3.8142613496884374 1.6269687414169312 101.80903809564259 477.561746519742 51.723420957455346 311.27910058100616 197.29470524280362 1168.1052332187346 DOWN 0.38461538461538464 0.6153846153846154 0.0 GO:0006690 6 icosanoid metabolic process 39 48 4 4 4 3 3 3 65 45 2434 0.96255 0.13477 0.13477 6.25 24426;25315;81639 gstp1;ephx1;alox15 GSTP1_8762;EPHX1_8567;ALOX15_8036 273.60673333333335 39.2381 14.7631 427.30962006384 329.08248567367815 444.34147054412733 149.81220666666667 18.9587 9.42992 234.9454002549191 180.16954291074472 244.4725392183248 923.1620333333334 81.6965 25.7196 1506.1985396142184 1117.5884348493462 1567.4845496736139 1.5 403.02855 14.7631;39.2381;766.819 9.42992;18.9587;421.048 25.7196;81.6965;2662.07 2 1 2 24426;25315 GSTP1_8762;EPHX1_8567 27.000600000000002 27.000600000000002 17.306438469540755 14.19431 14.19431 6.737864954434749 53.70805 53.70805 39.581645579801254 14.7631;39.2381 9.42992;18.9587 25.7196;81.6965 1 81639 ALOX15_8036 766.819 766.819 421.048 421.048 2662.07 2662.07 766.819 421.048 2662.07 0 Exp 2,1(0.34);Exp 4,2(0.67) 2.2142591849114694 7.078766942024231 1.5021449327468872 3.5281898975372314 1.048250207561143 2.0484321117401123 -209.93962204216922 757.1530887088359 -116.05354189413549 415.67795522746883 -781.2620659732754 2627.5861326399418 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0007346 6 regulation of mitotic cell cycle 146 155 9 9 7 6 5 5 63 150 2329 0.76974 0.39914 0.6047 3.23 315852;360243;291234;24296;25612 ttk;top2a;mki67;cyp1a1;asns TTK_32727;TOP2A_10059;MKI67_9232;CYP1A1_8415;ASNS_8091 209.94034000000002 86.3883 12.8863 303.29776815911947 188.98690280649924 266.6631083452902 120.56714 26.6888 6.82654 187.43717074753556 105.60915068893685 166.19261167930233 595.2265600000001 262.273 19.3234 867.1658422762557 535.6338631670643 760.4824372526407 737.351;86.3883;21.9311;12.8863;191.145 446.625;26.6888;6.82654;9.13136;113.564 2108.09;262.273;76.1794;19.3234;510.267 1 4 1 24296 CYP1A1_8415 12.8863 12.8863 9.13136 9.13136 19.3234 19.3234 12.8863 9.13136 19.3234 4 315852;360243;291234;25612 TTK_32727;TOP2A_10059;MKI67_9232;ASNS_8091 259.20385 138.76665 326.30265926529523 148.426085 70.12639999999999 204.1309674213287 739.20235 386.27 929.7537003458265 737.351;86.3883;21.9311;191.145 446.625;26.6888;6.82654;113.564 2108.09;262.273;76.1794;510.267 0 Exp 4,3(0.6);Linear,1(0.2);Poly 2,1(0.2) 2.7566954462794366 22.686121225357056 1.5111545324325562 15.48720932006836 6.123760652645067 1.922041654586792 -55.911875394882884 475.79255539488287 -43.72878407827602 284.863064078276 -164.87781426946287 1355.330934269463 DOWN 0.2 0.8 0.0 GO:0046677 4 response to antibiotic 202 218 20 19 12 11 7 7 61 211 2268 0.77797 0.3628 0.51506 3.21 24314;81687;24426;361921;24296;29221;170913 nqo1;mmp9;gstp1;ect2;cyp1a1;arg1;abcb1a NQO1_33055;MMP9_32531;GSTP1_8762;ECT2_8523;CYP1A1_8415;ARG1_33267;ABCB1A_7938 251.36741428571426 25.6813 10.0162 344.27229146845104 274.15812805417005 347.7260370782357 143.48053857142855 9.42992 3.29405 198.95872772401052 156.939114258393 202.88062050176148 911.3478000000001 86.1211 19.3234 1130.5332907639427 997.9315923396996 1119.671677921562 25.6813;728.316;14.7631;10.0162;12.8863;760.927;206.982 7.73944;443.137;9.42992;3.29405;9.13136;413.607;118.025 86.1211;2039.06;25.7196;37.7305;19.3234;2639.93;1531.55 3 4 3 24314;24426;24296 NQO1_33055;GSTP1_8762;CYP1A1_8415 17.7769 14.7631 6.909431892710139 8.766906666666667 9.13136 0.9022473783466 43.72136666666666 25.7196 36.85825394214075 25.6813;14.7631;12.8863 7.73944;9.42992;9.13136 86.1211;25.7196;19.3234 4 81687;361921;29221;170913 MMP9_32531;ECT2_8523;ARG1_33267;ABCB1A_7938 426.5603 467.649 376.20083715442934 244.5157625 265.81600000000003 217.73842882732555 1562.067625 1785.3049999999998 1112.6311190653273 728.316;10.0162;760.927;206.982 443.137;3.29405;413.607;118.025 2039.06;37.7305;2639.93;1531.55 0 Exp 2,1(0.15);Exp 4,3(0.43);Hill,1(0.15);Linear,1(0.15);Poly 2,1(0.15) 2.7327674692315265 28.27645969390869 1.513624906539917 15.48720932006836 5.091459332641839 2.05134654045105 -3.673068338727944 506.4078969101566 -3.9101495511636415 290.87122669402083 73.83701785255698 1748.8585821474428 CONFLICT 0.42857142857142855 0.5714285714285714 0.0 GO:0030198 6 extracellular matrix organization 60 68 6 5 3 5 3 3 65 65 2414 0.89408 0.27203 0.42691 4.41 288583;81687;84032 plod3;mmp9;col3a1 PLOD3_9507;MMP9_32531;COL3A1_8354 607.8493333333334 728.316 212.603 350.8815662047998 633.217649067198 290.92176544811537 396.208 443.137 119.81 256.1778751239068 397.14304174968294 202.81946916647874 1551.9233333333334 1510.69 1106.02 467.8846559071291 1768.3021907263173 441.1246228402084 882.629;728.316;212.603 625.677;443.137;119.81 1106.02;2039.06;1510.69 0 3 0 3 288583;81687;84032 PLOD3_9507;MMP9_32531;COL3A1_8354 607.8493333333334 728.316 350.8815662047998 396.208 443.137 256.1778751239068 1551.9233333333334 1510.69 467.8846559071291 882.629;728.316;212.603 625.677;443.137;119.81 1106.02;2039.06;1510.69 0 Linear,1(0.34);Poly 2,2(0.67) 1.7840269143974714 5.380400896072388 1.6129854917526245 2.05134654045105 0.22920068027722526 1.7160688638687134 210.78946259737683 1004.9092040692901 106.31544428010068 686.1005557198994 1022.4620025394867 2081.3846641271803 DOWN 0.0 1.0 0.0 GO:0045860 8 positive regulation of protein kinase activity 136 148 7 7 3 4 2 2 66 146 2333 0.2327 0.91425 0.43268 1.35 361921;24854 ect2;clu ECT2_8523;CLU_32773 472.8326 472.8326 10.0162 654.5212297686912 359.49255200929605 634.5912915104096 405.889025 405.889025 3.29405 569.3552737882573 307.2967240631354 552.0186085472579 554.3902499999999 554.3902499999999 37.7305 730.6672255822926 427.8643946935218 708.4186688802414 10.0162;935.649 3.29405;808.484 37.7305;1071.05 0 2 0 2 361921;24854 ECT2_8523;CLU_32773 472.8326 472.8326 654.5212297686912 405.889025 405.889025 569.3552737882573 554.3902499999999 554.3902499999999 730.6672255822926 10.0162;935.649 3.29405;808.484 37.7305;1071.05 0 Exp 4,1(0.5);Poly 2,1(0.5) 1.59483336980305 3.1906944513320923 1.5548590421676636 1.6358354091644287 0.05725893821926317 1.5953472256660461 -434.28754399999997 1379.952744 -383.19712600000014 1194.9751760000004 -458.26285999999993 1567.0433600000001 DOWN 0.0 1.0 0.0 GO:0031667 5 response to nutrient levels 239 256 26 26 20 19 16 16 52 240 2239 0.99974 8.0662E-4 8.0662E-4 6.25 116669;25682;363131;362282;24314;81687;24426;25283;312495;24296;245920;246142;25612;29221;24646;170913 vwf;ppard;pik3r4;pck1;nqo1;mmp9;gstp1;gclc;cyp26b1;cyp1a1;cxcl10;bmf;asns;arg1;abcb1b;abcb1a VWF_32396;PPARD_9536;PIK3R4_9484;PCK1_9439;NQO1_33055;MMP9_32531;GSTP1_8762;GCLC_8699;CYP26B1_8418;CYP1A1_8415;CXCL10_8408;BMF_8152;ASNS_8091;ARG1_33267;ABCB1B_7939;ABCB1A_7938 281.247925 125.5505 12.8863 327.4964804166573 203.47568365128757 278.2344007101115 172.715494375 60.87219999999999 4.11644 221.43668993353913 117.19580807694041 176.75864314833345 754.44354375 308.647 19.3234 871.9114190019785 625.2288543521398 841.2224936440879 11.5 599.886 19.6764;94.1074;955.628;529.244;25.6813;728.316;14.7631;131.7;18.1872;12.8863;670.528;119.401;191.145;760.927;20.7941;206.982 4.11644;37.7692;735.228;356.883;7.73944;443.137;9.42992;39.9158;10.0176;9.13136;374.802;81.8286;113.564;413.607;8.25355;118.025 94.078;148.485;1288.97;1021.06;86.1211;2039.06;25.7196;397.209;36.7271;19.3234;1955.3;220.085;510.267;2639.93;57.2115;1531.55 5 11 5 362282;24314;24426;312495;24296 PCK1_9439;NQO1_33055;GSTP1_8762;CYP26B1_8418;CYP1A1_8415 120.15238 18.1872 228.7414198940083 78.640264 9.42992 155.5446691845956 237.79023999999998 36.7271 438.6465398686771 529.244;25.6813;14.7631;18.1872;12.8863 356.883;7.73944;9.42992;10.0176;9.13136 1021.06;86.1211;25.7196;36.7271;19.3234 11 116669;25682;363131;81687;25283;245920;246142;25612;29221;24646;170913 VWF_32396;PPARD_9536;PIK3R4_9484;MMP9_32531;GCLC_8699;CXCL10_8408;BMF_8152;ASNS_8091;ARG1_33267;ABCB1B_7939;ABCB1A_7938 354.4731727272728 191.145 347.96241787480466 215.4769627272727 113.564 239.6605554740373 989.2859545454546 510.267 932.3350241552778 19.6764;94.1074;955.628;728.316;131.7;670.528;119.401;191.145;760.927;20.7941;206.982 4.11644;37.7692;735.228;443.137;39.9158;374.802;81.8286;113.564;413.607;8.25355;118.025 94.078;148.485;1288.97;2039.06;397.209;1955.3;220.085;510.267;2639.93;57.2115;1531.55 0 Exp 2,2(0.13);Exp 4,3(0.19);Exp 5,1(0.07);Hill,4(0.25);Linear,2(0.13);Poly 2,4(0.25) 2.3616446700301537 49.30269122123718 1.5018656253814697 15.48720932006836 3.50248985998094 1.9567941427230835 120.77464959583793 441.7212004041621 64.21151630756583 281.21947244243415 327.2069484390305 1181.6801390609694 DOWN 0.3125 0.6875 0.0 GO:0048731 4 system development 102 110 8 7 3 5 3 3 65 107 2372 0.66209 0.57007 1.0 2.73 81687;361921;84032 mmp9;ect2;col3a1 MMP9_32531;ECT2_8523;COL3A1_8354 316.9784 212.603 10.0162 370.35026497071664 350.4862655001272 409.1724472507664 188.74701666666667 119.81 3.29405 227.88086660874106 210.54913224739116 251.19531087247006 1195.8268333333333 1510.69 37.7305 1037.1518944615023 1134.3958617968947 1139.2703352368098 728.316;10.0162;212.603 443.137;3.29405;119.81 2039.06;37.7305;1510.69 0 3 0 3 81687;361921;84032 MMP9_32531;ECT2_8523;COL3A1_8354 316.9784 212.603 370.35026497071664 188.74701666666667 119.81 227.88086660874106 1195.8268333333333 1510.69 1037.1518944615023 728.316;10.0162;212.603 443.137;3.29405;119.81 2039.06;37.7305;1510.69 0 Exp 4,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 1.7557783909131317 5.300167441368103 1.6129854917526245 2.05134654045105 0.24675629946865832 1.6358354091644287 -102.1123773435732 736.0691773435733 -69.12445950558819 446.6184928389215 22.17897943589105 2369.4746872307755 DOWN 0.0 1.0 0.0 GO:0008202 5 steroid metabolic process 95 104 7 7 5 6 5 5 63 99 2380 0.94341 0.14205 0.19854 4.81 286989;64191;312495;24296;113902 ugt2b7;dhcr7;cyp26b1;cyp1a1;ces1d UGT2B7_33032;DHCR7_8466;CYP26B1_8418;CYP1A1_8415;CES1D_32914 47.7113 18.1872 11.0684 64.4010891103559 70.35399541836391 74.63968710633534 17.802798000000003 10.0176 4.18343 18.8843278853821 24.73228262939572 21.44796102604056 131.92958 36.7271 17.0564 198.66730097895328 202.29696931125974 229.11893461671775 34.7126;161.702;18.1872;12.8863;11.0684 14.7729;50.9087;10.0176;9.13136;4.18343 105.024;481.517;36.7271;19.3234;17.0564 3 2 3 286989;312495;24296 UGT2B7_33032;CYP26B1_8418;CYP1A1_8415 21.928700000000003 18.1872 11.384022119180901 11.307286666666668 10.0176 3.0338444532528897 53.6915 36.7271 45.29891125192746 34.7126;18.1872;12.8863 14.7729;10.0176;9.13136 105.024;36.7271;19.3234 2 64191;113902 DHCR7_8466;CES1D_32914 86.3852 86.3852 106.51404003454194 27.546065000000002 27.546065000000002 33.03975526977236 249.2867 249.2867 328.4232398539726 161.702;11.0684 50.9087;4.18343 481.517;17.0564 0 Exp 4,4(0.8);Exp 5,1(0.2) 3.545216343451707 26.928122997283936 1.6269687414169312 15.48720932006836 5.921023495008299 2.090334892272949 -8.738743525704663 104.16134352570467 1.249954782445183 34.35564121755482 -42.20998723897719 306.06914723897717 UP 0.6 0.4 0.0 GO:0071377 7 cellular response to glucagon stimulus 7 7 2 2 2 2 2 2 66 5 2474 0.99941 0.013527 0.013527 28.57 362282;29221 pck1;arg1 PCK1_9439;ARG1_33267 645.0855 645.0855 529.244 163.8246203856427 717.7222132104455 127.61787505074268 385.245 385.245 356.883 40.10992505602587 403.0289760368664 31.245263331268312 1830.495 1830.495 1021.06 1144.7139548594662 2338.039342549923 891.7216601278317 0.0 529.244 0.0 529.244 529.244;760.927 356.883;413.607 1021.06;2639.93 1 1 1 362282 PCK1_9439 529.244 529.244 356.883 356.883 1021.06 1021.06 529.244 356.883 1021.06 1 29221 ARG1_33267 760.927 760.927 413.607 413.607 2639.93 2639.93 760.927 413.607 2639.93 0 Exp 2,1(0.5);Linear,1(0.5) 1.561753544199049 3.125037431716919 1.513624906539917 1.611412525177002 0.06914628825436679 1.5625187158584595 418.03616000000005 872.1348399999999 329.65547999999995 440.83452000000005 244.00240000000008 3416.9875999999995 CONFLICT 0.5 0.5 0.0 GO:0042592 4 homeostatic process 357 379 30 29 17 18 13 13 55 366 2113 0.87659 0.20168 0.30222 3.43 24832;25671;362282;259241;24314;25283;312495;245920;113902;686019;81639;252898;170913 thy1;smad1;pck1;nr1d2;nqo1;gclc;cyp26b1;cxcl10;ces1d;casq1;alox15;acox2;abcb1a THY1_33010;SMAD1_32578;PCK1_9439;NR1D2_9358;NQO1_33055;GCLC_8699;CYP26B1_8418;CXCL10_8408;CES1D_32914;CASQ1_32992;ALOX15_8036;ACOX2_32902;ABCB1A_7938 254.0302307692312 131.7 5.72311E-12 304.9347028590062 202.5521570314744 263.8292041047995 143.85615384615429 39.9158 5.72311E-12 179.87296007627245 110.25993224571798 152.97498090292603 805.7569769230774 285.773 5.72313E-12 972.9575493239232 704.3501610547636 917.8004805989159 5.72311E-12;21.9973;529.244;29.1728;25.6813;131.7;18.1872;670.528;11.0684;147.66;766.819;743.353;206.982 5.72311E-12;5.02186;356.883;3.35457;7.73944;39.9158;10.0176;374.802;4.18343;96.6023;421.048;432.537;118.025 5.72313E-12;80.1461;1021.06;114.038;86.1211;397.209;36.7271;1955.3;17.0564;285.773;2662.07;2287.79;1531.55 4 9 4 362282;259241;24314;312495 PCK1_9439;NR1D2_9358;NQO1_33055;CYP26B1_8418 150.571325 27.42705 252.49004703839157 94.49865249999999 8.87852 174.94475201511997 314.48654999999997 100.07955 472.1323092312189 529.244;29.1728;25.6813;18.1872 356.883;3.35457;7.73944;10.0176 1021.06;114.038;86.1211;36.7271 9 24832;25671;25283;245920;113902;686019;81639;252898;170913 THY1_33010;SMAD1_32578;GCLC_8699;CXCL10_8408;CES1D_32914;CASQ1_32992;ALOX15_8036;ACOX2_32902;ABCB1A_7938 300.01196666666726 147.66 328.39087675265824 165.79282111111175 96.6023 187.86922789986275 1024.0993888888895 397.209 1077.9948255866536 5.72311E-12;21.9973;131.7;670.528;11.0684;147.66;766.819;743.353;206.982 5.72311E-12;5.02186;39.9158;374.802;4.18343;96.6023;421.048;432.537;118.025 5.72313E-12;80.1461;397.209;1955.3;17.0564;285.773;2662.07;2287.79;1531.55 0 Exp 2,3(0.24);Exp 4,3(0.24);Exp 5,1(0.08);Hill,3(0.24);Linear,1(0.08);Poly 2,2(0.16) 1.8528533326275078 24.317438006401062 1.5021449327468872 2.327066659927368 0.2684909561593186 1.863204002380371 88.26583804769405 419.79462349076846 46.076098921231576 241.636208771077 276.8512282648551 1334.6627255812998 DOWN 0.3076923076923077 0.6923076923076923 0.0 GO:0071702 5 organic substance transport 316 335 18 18 14 15 12 12 56 323 2156 0.89833 0.17431 0.27366 3.58 313089;294881;170551;89776;25682;363131;24367;24854;113902;29657;24646;170913 slc7a13;slc7a12;slc5a6;slc22a7;ppard;pik3r4;fgg;clu;ces1d;arntl;abcb1b;abcb1a SLC7A13_32952;SLC7A12_32838;SLC5A6_9881;SLC22A7_9847;PPARD_9536;PIK3R4_9484;FGG_8639;CLU_32773;CES1D_32914;ARNTL_8086;ABCB1B_7939;ABCB1A_7938 241.22328333333334 71.62950000000001 11.0684 346.62025085557735 180.57523909635538 282.3367583600583 177.94363166666665 29.205799999999996 4.18343 288.5515080010656 127.8481446784413 238.81792849384703 453.7839583333334 154.89600000000002 17.0564 544.3752304942535 416.0549285647692 533.2843811092022 397.931;37.9163;120.077;49.1516;94.1074;955.628;42.4612;935.649;11.0684;22.9134;20.7941;206.982 280.111;15.3983;82.2177;13.5995;37.7692;735.228;20.6424;808.484;4.18343;11.4115;8.25355;118.025 668.129;132.15;221.286;161.307;148.485;1288.97;98.0534;1071.05;17.0564;50.1592;57.2115;1531.55 0 12 0 12 313089;294881;170551;89776;25682;363131;24367;24854;113902;29657;24646;170913 SLC7A13_32952;SLC7A12_32838;SLC5A6_9881;SLC22A7_9847;PPARD_9536;PIK3R4_9484;FGG_8639;CLU_32773;CES1D_32914;ARNTL_8086;ABCB1B_7939;ABCB1A_7938 241.22328333333334 71.62950000000001 346.62025085557735 177.94363166666665 29.205799999999996 288.5515080010656 453.7839583333334 154.89600000000002 544.3752304942535 397.931;37.9163;120.077;49.1516;94.1074;955.628;42.4612;935.649;11.0684;22.9134;20.7941;206.982 280.111;15.3983;82.2177;13.5995;37.7692;735.228;20.6424;808.484;4.18343;11.4115;8.25355;118.025 668.129;132.15;221.286;161.307;148.485;1288.97;98.0534;1071.05;17.0564;50.1592;57.2115;1531.55 0 Exp 2,1(0.09);Exp 4,3(0.25);Exp 5,2(0.17);Hill,2(0.17);Poly 2,4(0.34) 2.1703458970499923 28.66422927379608 1.5018656253814697 6.191005229949951 1.3312636574237573 1.9053296446800232 45.104414098050995 437.34215256861563 14.680246663568738 341.2070166697646 145.7746761846318 761.7932404820347 DOWN 0.0 1.0 0.0 GO:0000281 5 mitotic cytokinesis 13 16 4 4 4 2 2 2 66 14 2465 0.99205 0.066251 0.066251 12.5 361921;306575 ect2;ckap2 ECT2_8523;CKAP2_8324 21.127399999999998 21.127399999999998 10.0162 15.713609734239933 22.353776306137984 15.617603311375479 9.281175 9.281175 3.29405 8.467073374623018 9.941991855234932 8.415341567573169 57.21785 57.21785 37.7305 27.559274664711346 59.368726980831774 27.390894042941667 0.0 10.0162 0.5 21.127399999999998 10.0162;32.2386 3.29405;15.2683 37.7305;76.7052 0 2 0 2 361921;306575 ECT2_8523;CKAP2_8324 21.127399999999998 21.127399999999998 15.713609734239933 9.281175 9.281175 8.467073374623018 57.21785 57.21785 27.559274664711346 10.0162;32.2386 3.29405;15.2683 37.7305;76.7052 0 Exp 4,2(1) 1.8349125150551113 3.694052219390869 1.6358354091644287 2.0582168102264404 0.2986687529380233 1.8470261096954346 -0.6505519999999976 42.905352 -2.45359 21.01594 19.022643999999993 95.41305600000001 DOWN 0.0 1.0 0.0 GO:0006751 6 glutathione catabolic process 2 2 1 1 1 1 1 1 67 1 2478 0.9993 0.052694 0.052694 50.0 156275 ggt7 GGT7_33026 109.609 109.609 109.609 109.609 29.3336 29.3336 29.3336 29.3336 346.073 346.073 346.073 346.073 0.0 109.609 0.0 109.609 109.609 29.3336 346.073 0 1 0 1 156275 GGT7_33026 109.609 109.609 29.3336 29.3336 346.073 346.073 109.609 29.3336 346.073 0 Exp 4,1(1) 1.930785894393921 1.930785894393921 1.930785894393921 1.930785894393921 0.0 1.930785894393921 109.609 109.609 29.3336 29.3336 346.073 346.073 DOWN 0.0 1.0 0.0 GO:0035296 6 regulation of tube diameter 54 57 8 8 6 6 4 4 64 53 2426 0.98328 0.063681 0.063681 7.02 25682;288583;25283;24367 ppard;plod3;gclc;fgg PPARD_9536;PLOD3_9507;GCLC_8699;FGG_8639 287.7244 112.90369999999999 42.4612 398.2866122361969 157.99009285377136 255.17053586431993 181.0011 38.8425 20.6424 296.5760204737846 81.77510383271972 188.94661396620808 437.44185 272.847 98.0534 464.5054739655462 312.74664297177384 316.11463928606315 1.5 112.90369999999999 94.1074;882.629;131.7;42.4612 37.7692;625.677;39.9158;20.6424 148.485;1106.02;397.209;98.0534 0 4 0 4 25682;288583;25283;24367 PPARD_9536;PLOD3_9507;GCLC_8699;FGG_8639 287.7244 112.90369999999999 398.2866122361969 181.0011 38.8425 296.5760204737846 437.44185 272.847 464.5054739655462 94.1074;882.629;131.7;42.4612 37.7692;625.677;39.9158;20.6424 148.485;1106.02;397.209;98.0534 0 Exp 4,1(0.25);Exp 5,1(0.25);Hill,1(0.25);Poly 2,1(0.25) 2.074285216912495 8.447295308113098 1.7160688638687134 2.8176381587982178 0.484253627996331 1.9567941427230835 -102.59647999147296 678.045279991473 -109.64340006430888 471.6456000643089 -17.77351448623517 892.6572144862351 DOWN 0.0 1.0 0.0 GO:0097746 6 regulation of blood vessel diameter 54 57 8 8 6 6 4 4 64 53 2426 0.98328 0.063681 0.063681 7.02 25682;288583;25283;24367 ppard;plod3;gclc;fgg PPARD_9536;PLOD3_9507;GCLC_8699;FGG_8639 287.7244 112.90369999999999 42.4612 398.2866122361969 157.99009285377136 255.17053586431993 181.0011 38.8425 20.6424 296.5760204737846 81.77510383271972 188.94661396620808 437.44185 272.847 98.0534 464.5054739655462 312.74664297177384 316.11463928606315 1.5 112.90369999999999 94.1074;882.629;131.7;42.4612 37.7692;625.677;39.9158;20.6424 148.485;1106.02;397.209;98.0534 0 4 0 4 25682;288583;25283;24367 PPARD_9536;PLOD3_9507;GCLC_8699;FGG_8639 287.7244 112.90369999999999 398.2866122361969 181.0011 38.8425 296.5760204737846 437.44185 272.847 464.5054739655462 94.1074;882.629;131.7;42.4612 37.7692;625.677;39.9158;20.6424 148.485;1106.02;397.209;98.0534 0 Exp 4,1(0.25);Exp 5,1(0.25);Hill,1(0.25);Poly 2,1(0.25) 2.074285216912495 8.447295308113098 1.7160688638687134 2.8176381587982178 0.484253627996331 1.9567941427230835 -102.59647999147296 678.045279991473 -109.64340006430888 471.6456000643089 -17.77351448623517 892.6572144862351 DOWN 0.0 1.0 0.0 GO:0071277 7 cellular response to calcium ion 24 25 3 3 2 2 2 2 66 23 2456 0.97249 0.14238 0.14238 8.0 361921;81639 ect2;alox15 ECT2_8523;ALOX15_8036 388.4176 388.4176 10.0162 535.1403919009664 341.5805036363636 531.0252459651676 212.17102500000001 212.17102500000001 3.29405 295.3966509124659 186.31702180069928 293.1250968570285 1349.9002500000001 1349.9002500000001 37.7305 1855.6882565857136 1187.4848333916082 1841.4183040596647 0.5 388.4176 10.0162;766.819 3.29405;421.048 37.7305;2662.07 0 2 0 2 361921;81639 ECT2_8523;ALOX15_8036 388.4176 388.4176 535.1403919009664 212.17102500000001 212.17102500000001 295.3966509124659 1349.9002500000001 1349.9002500000001 1855.6882565857136 10.0162;766.819 3.29405;421.048 37.7305;2662.07 0 Exp 2,1(0.5);Exp 4,1(0.5) 1.567565587362863 3.137980341911316 1.5021449327468872 1.6358354091644287 0.09453344245490382 1.568990170955658 -353.2491439999998 1130.0843439999999 -197.227846 621.569896 -1221.9524600000002 3921.75296 DOWN 0.0 1.0 0.0 GO:0001959 6 regulation of cytokine-mediated signaling pathway 30 30 3 3 3 2 2 2 66 28 2451 0.95581 0.19005 0.19005 6.67 688621;29221 tslp;arg1 TSLP_32811;ARG1_33267 552.801 552.801 344.675 294.33461188246264 535.1095708362128 293.26931380607397 328.9035 328.9035 244.2 119.78883848046938 321.70340981340706 119.35528152163964 1600.1825 1600.1825 560.435 1470.4250159435194 1511.8003697304766 1465.1030426596428 0.5 552.801 344.675;760.927 244.2;413.607 560.435;2639.93 0 2 0 2 688621;29221 TSLP_32811;ARG1_33267 552.801 552.801 294.33461188246264 328.9035 328.9035 119.78883848046938 1600.1825 1600.1825 1470.4250159435194 344.675;760.927 244.2;413.607 560.435;2639.93 0 Exp 2,2(1) 1.5974240299185045 3.1994874477386475 1.513624906539917 1.6858625411987305 0.12179039944277814 1.5997437238693237 144.87404000000004 960.72796 162.88464 494.92236 -437.72259999999983 3638.0876 DOWN 0.0 1.0 0.0 GO:0007160 5 cell-matrix adhesion 28 28 4 4 3 3 3 3 65 25 2454 0.99413 0.037024 0.037024 10.71 24367;309186;84032 fgg;fermt3;col3a1 FGG_8639;FERMT3_32542;COL3A1_8354 264.7257333333334 212.603 42.4612 252.3952002483671 204.32653130180788 253.84644661209353 158.23346666666666 119.81 20.6424 160.29469791871887 121.17923028341359 160.25852687385867 932.2011333333334 1187.86 98.0534 740.2071554597762 663.3588068998184 763.5823328105068 0.5 127.5321 1.5 375.85800000000006 42.4612;539.113;212.603 20.6424;334.248;119.81 98.0534;1187.86;1510.69 0 3 0 3 24367;309186;84032 FGG_8639;FERMT3_32542;COL3A1_8354 264.7257333333334 212.603 252.3952002483671 158.23346666666666 119.81 160.29469791871887 932.2011333333334 1187.86 740.2071554597762 42.4612;539.113;212.603 20.6424;334.248;119.81 98.0534;1187.86;1510.69 0 Exp 2,1(0.34);Exp 4,1(0.34);Poly 2,1(0.34) 1.9653646364026434 6.100997686386108 1.6129854917526245 2.8176381587982178 0.6795459833656019 1.6703740358352661 -20.88632280557266 550.3377894722394 -23.15705983969579 339.62399317302913 94.57788443018694 1769.8243822364796 DOWN 0.0 1.0 0.0 GO:0009888 4 tissue development 153 164 10 10 7 7 5 5 63 159 2320 0.72876 0.44792 0.62244 3.05 25671;25682;288583;686019;81639 smad1;ppard;plod3;casq1;alox15 SMAD1_32578;PPARD_9536;PLOD3_9507;CASQ1_32992;ALOX15_8036 382.64254 147.66 21.9973 408.07852273055 338.8273673756514 354.8901217285398 237.223672 96.6023 5.02186 273.020837006524 201.57090371009002 218.9152337433165 856.49882 285.773 80.1461 1089.9636670655873 881.1680949644717 1144.5123555232549 21.9973;94.1074;882.629;147.66;766.819 5.02186;37.7692;625.677;96.6023;421.048 80.1461;148.485;1106.02;285.773;2662.07 0 5 0 5 25671;25682;288583;686019;81639 SMAD1_32578;PPARD_9536;PLOD3_9507;CASQ1_32992;ALOX15_8036 382.64254 147.66 408.07852273055 237.223672 96.6023 273.020837006524 856.49882 285.773 1089.9636670655873 21.9973;94.1074;882.629;147.66;766.819 5.02186;37.7692;625.677;96.6023;421.048 80.1461;148.485;1106.02;285.773;2662.07 0 Exp 2,1(0.2);Exp 4,1(0.2);Exp 5,1(0.2);Poly 2,2(0.4) 1.81494958371965 9.177395105361938 1.5021449327468872 2.327066659927368 0.3154217193789436 1.7160688638687134 24.94594374258446 740.3391362574155 -2.0896431216272333 476.53698712162725 -98.8964582049316 1811.8940982049317 DOWN 0.0 1.0 0.0 GO:0010035 4 response to inorganic substance 271 293 24 23 16 16 12 12 56 281 2198 0.9575 0.083591 0.12073 4.1 24314;81687;25283;24367;361921;24296;24854;114494;24232;29221;81639;170913 nqo1;mmp9;gclc;fgg;ect2;cyp1a1;clu;ccna2;c3;arg1;alox15;abcb1a NQO1_33055;MMP9_32531;GCLC_8699;FGG_8639;ECT2_8523;CYP1A1_8415;CLU_32773;CCNA2_8221;C3_8175;ARG1_33267;ALOX15_8036;ABCB1A_7938 322.5484166666667 169.341 10.0162 362.1512418292537 295.87234534044654 349.49610120377963 201.58867 78.9704 3.29405 259.9859427326616 178.3058623427832 241.87229686073928 944.5469833333333 545.7125 19.3234 1029.665015459906 913.64426174037 1028.0303104272077 25.6813;728.316;131.7;42.4612;10.0162;12.8863;935.649;14.384;234.759;760.927;766.819;206.982 7.73944;443.137;39.9158;20.6424;3.29405;9.13136;808.484;4.89199;129.148;413.607;421.048;118.025 86.1211;2039.06;397.209;98.0534;37.7305;19.3234;1071.05;58.2504;694.216;2639.93;2662.07;1531.55 2 10 2 24314;24296 NQO1_33055;CYP1A1_8415 19.2838 19.2838 9.047431265281876 8.435400000000001 8.435400000000001 0.9842360708691725 52.72225 52.72225 47.23310663766464 25.6813;12.8863 7.73944;9.13136 86.1211;19.3234 10 81687;25283;24367;361921;24854;114494;24232;29221;81639;170913 MMP9_32531;GCLC_8699;FGG_8639;ECT2_8523;CLU_32773;CCNA2_8221;C3_8175;ARG1_33267;ALOX15_8036;ABCB1A_7938 383.20133999999996 220.8705 368.46230909279114 240.219324 123.5865 269.5632228822093 1122.91193 882.633 1040.8989846578515 728.316;131.7;42.4612;10.0162;935.649;14.384;234.759;760.927;766.819;206.982 443.137;39.9158;20.6424;3.29405;808.484;4.89199;129.148;413.607;421.048;118.025 2039.06;397.209;98.0534;37.7305;1071.05;58.2504;694.216;2639.93;2662.07;1531.55 0 Exp 2,2(0.17);Exp 4,4(0.34);Hill,2(0.17);Linear,1(0.09);Poly 2,3(0.25) 2.1640509521919613 35.77115750312805 1.5021449327468872 15.48720932006836 3.956954210214746 1.7616559267044067 117.64206204833931 527.454771284994 54.48777505822355 348.68956494177644 361.9591569594346 1527.1348097072319 DOWN 0.16666666666666666 0.8333333333333334 0.0 GO:0080135 5 regulation of cellular response to stress 165 174 10 10 6 5 5 5 63 169 2310 0.68123 0.50103 0.80652 2.87 24832;316351;24426;24854;29657 thy1;npas2;gstp1;clu;arntl THY1_33010;NPAS2_9350;GSTP1_8762;CLU_32773;ARNTL_8086 198.88266000000115 21.0878 5.72311E-12 411.9633349242472 226.67898016675653 433.9848589132419 168.13118400000116 11.3305 5.72311E-12 357.99910231853073 192.50878598308907 377.01282571393926 238.0982400000011 43.5624 5.72313E-12 466.0389921742249 268.87413004553366 491.28101628367114 5.72311E-12;21.0878;14.7631;935.649;22.9134 5.72311E-12;11.3305;9.42992;808.484;11.4115 5.72313E-12;43.5624;25.7196;1071.05;50.1592 1 4 1 24426 GSTP1_8762 14.7631 14.7631 9.42992 9.42992 25.7196 25.7196 14.7631 9.42992 25.7196 4 24832;316351;24854;29657 THY1_33010;NPAS2_9350;CLU_32773;ARNTL_8086 244.91255000000143 22.0006 460.60834477148705 207.80650000000145 11.371 400.4875424818679 291.19290000000143 46.8608 520.3807934249548 5.72311E-12;21.0878;935.649;22.9134 5.72311E-12;11.3305;808.484;11.4115 5.72313E-12;43.5624;1071.05;50.1592 0 Exp 4,3(0.6);Hill,1(0.2);Poly 2,1(0.2) 2.553427887552004 13.473699688911438 1.5548590421676636 3.5281898975372314 0.9215705349569842 3.0844674110412598 -162.21912428222572 559.984444282228 -145.6688648379086 481.9312328379109 -170.40294773348614 646.5994277334885 DOWN 0.2 0.8 0.0 GO:1904386 6 response to L-phenylalanine derivative 7 7 2 2 2 2 2 2 66 5 2474 0.99941 0.013527 0.013527 28.57 25283;170913 gclc;abcb1a GCLC_8699;ABCB1A_7938 169.341 169.341 131.7 53.23241270128562 163.94732772441205 52.683074708744165 78.9704 78.9704 39.9158 55.231544993056296 73.37416947333554 54.66157672538232 964.3795 964.3795 397.209 802.1002132779292 883.1082319311029 793.8228480671536 0.0 131.7 0.0 131.7 131.7;206.982 39.9158;118.025 397.209;1531.55 0 2 0 2 25283;170913 GCLC_8699;ABCB1A_7938 169.341 169.341 53.23241270128562 78.9704 78.9704 55.231544993056296 964.3795 964.3795 802.1002132779292 131.7;206.982 39.9158;118.025 397.209;1531.55 0 Hill,1(0.5);Poly 2,1(0.5) 1.9305903786298881 3.8621655702590942 1.8874764442443848 1.9746891260147095 0.06166867868526099 1.9310827851295471 95.56464 243.11736000000002 2.4233839999999987 155.51741600000003 -147.27467999999976 2076.0336799999995 DOWN 0.0 1.0 0.0 GO:1902975 9 mitotic DNA replication initiation 4 4 1 1 1 1 1 1 67 3 2476 0.99593 0.10265 0.10265 25.0 316273 mcm3 MCM3_9207 197.273 197.273 197.273 197.27299999999997 116.413 116.413 116.413 116.413 496.915 496.915 496.915 496.915 0.0 197.273 0.0 197.273 197.273 116.413 496.915 0 1 0 1 316273 MCM3_9207 197.273 197.273 116.413 116.413 496.915 496.915 197.273 116.413 496.915 0 Poly 2,1(1) 1.57428777217865 1.57428777217865 1.57428777217865 1.57428777217865 0.0 1.57428777217865 197.273 197.273 116.413 116.413 496.915 496.915 DOWN 0.0 1.0 0.0 GO:0032269 7 negative regulation of cellular protein metabolic process 274 292 18 16 10 8 6 6 62 286 2193 0.32175 0.80963 0.69812 2.05 24832;295703;81687;24426;25283;24232 thy1;serping1;mmp9;gstp1;gclc;c3 THY1_33010;SERPING1_32597;MMP9_32531;GSTP1_8762;GCLC_8699;C3_8175 190.3229666666676 82.04984999999999 5.72311E-12 278.148008719779 245.44151926905545 309.52397995257525 105.89358666666762 26.8233 5.72311E-12 171.83691445070824 134.8808202194296 195.3469615867622 542.6155166666676 248.34875 5.72313E-12 779.9290216204039 698.5662920802157 863.4601046854638 5.72311E-12;32.3997;728.316;14.7631;131.7;234.759 5.72311E-12;13.7308;443.137;9.42992;39.9158;129.148 5.72313E-12;99.4885;2039.06;25.7196;397.209;694.216 1 5 1 24426 GSTP1_8762 14.7631 14.7631 9.42992 9.42992 25.7196 25.7196 14.7631 9.42992 25.7196 5 24832;295703;81687;25283;24232 THY1_33010;SERPING1_32597;MMP9_32531;GCLC_8699;C3_8175 225.43494000000115 131.7 295.73892778643017 125.18632000000113 39.9158 184.71149061141716 645.9947000000011 397.209 824.7467380094316 5.72311E-12;32.3997;728.316;131.7;234.759 5.72311E-12;13.7308;443.137;39.9158;129.148 5.72313E-12;99.4885;2039.06;397.209;694.216 0 Exp 4,2(0.34);Hill,2(0.34);Linear,1(0.17);Poly 2,1(0.17) 2.033821296611294 12.682507991790771 1.5467612743377686 3.5281898975372314 0.7161688337446968 1.9189465641975403 -32.24179348265616 412.8877268159914 -31.60458139698237 243.3917547303176 -81.45767526231134 1166.6887085956466 DOWN 0.16666666666666666 0.8333333333333334 0.0 GO:0010243 5 response to organonitrogen compound 400 420 26 25 14 19 12 12 56 408 2071 0.67529 0.44832 0.74205 2.86 25671;25154;362282;81687;24426;25283;84032;113902;114494;25612;29221;170913 smad1;pgr;pck1;mmp9;gstp1;gclc;col3a1;ces1d;ccna2;asns;arg1;abcb1a SMAD1_32578;PGR_32824;PCK1_9439;MMP9_32531;GSTP1_8762;GCLC_8699;COL3A1_8354;CES1D_32914;CCNA2_8221;ASNS_8091;ARG1_33267;ABCB1A_7938 258.89565000000005 199.0635 11.0684 271.12947423683863 284.68656164370327 281.7116504787552 147.26500000000001 115.7945 4.18343 164.24304904634226 158.22646423602393 169.33035641593818 948.7623749999999 765.6635 17.0564 896.4614178298627 1040.2118352258015 919.1808007031952 21.9973;283.618;529.244;728.316;14.7631;131.7;212.603;11.0684;14.384;191.145;760.927;206.982 5.02186;138.711;356.883;443.137;9.42992;39.9158;119.81;4.18343;4.89199;113.564;413.607;118.025 80.1461;1554.21;1021.06;2039.06;25.7196;397.209;1510.69;17.0564;58.2504;510.267;2639.93;1531.55 2 10 2 362282;24426 PCK1_9439;GSTP1_8762 272.00355 272.00355 363.7929331809581 183.15645999999998 183.15645999999998 245.686429012152 523.3897999999999 523.3897999999999 703.8119464289307 529.244;14.7631 356.883;9.42992 1021.06;25.7196 10 25671;25154;81687;25283;84032;113902;114494;25612;29221;170913 SMAD1_32578;PGR_32824;MMP9_32531;GCLC_8699;COL3A1_8354;CES1D_32914;CCNA2_8221;ASNS_8091;ARG1_33267;ABCB1A_7938 256.27407 199.0635 274.0367880139861 140.086708 115.7945 160.9969208806498 1033.83689 1010.4785 937.518128307549 21.9973;283.618;728.316;131.7;212.603;11.0684;14.384;191.145;760.927;206.982 5.02186;138.711;443.137;39.9158;119.81;4.18343;4.89199;113.564;413.607;118.025 80.1461;1554.21;2039.06;397.209;1510.69;17.0564;58.2504;510.267;2639.93;1531.55 0 Exp 2,1(0.09);Exp 4,3(0.25);Exp 5,1(0.09);Hill,1(0.09);Linear,2(0.17);Poly 2,4(0.34) 1.8202267565482457 22.472671627998352 1.513624906539917 3.5281898975372314 0.5490271049253971 1.6600921154022217 105.48970856283711 412.30159143716287 54.335746792158034 240.194253207842 441.5415789158589 1455.983171084141 DOWN 0.16666666666666666 0.8333333333333334 0.0 GO:0031324 6 negative regulation of cellular metabolic process 513 545 31 28 19 16 12 12 56 533 1946 0.27529 0.81863 0.54893 2.2 24832;295703;25682;25154;259241;81687;24426;25283;24854;24232;246142;29657 thy1;serping1;ppard;pgr;nr1d2;mmp9;gstp1;gclc;clu;c3;bmf;arntl THY1_33010;SERPING1_32597;PPARD_9536;PGR_32824;NR1D2_9358;MMP9_32531;GSTP1_8762;GCLC_8699;CLU_32773;C3_8175;BMF_8152;ARNTL_8086 218.89995000000047 106.7542 5.72311E-12 302.9445501496074 246.6870549198817 312.57424900199743 143.07669916666714 38.8425 5.72311E-12 243.16475174159632 157.5554307628095 244.49564723677358 534.4766916666672 184.28500000000003 5.72313E-12 676.1370638354798 590.515754591494 714.3391327813454 5.72311E-12;32.3997;94.1074;283.618;29.1728;728.316;14.7631;131.7;935.649;234.759;119.401;22.9134 5.72311E-12;13.7308;37.7692;138.711;3.35457;443.137;9.42992;39.9158;808.484;129.148;81.8286;11.4115 5.72313E-12;99.4885;148.485;1554.21;114.038;2039.06;25.7196;397.209;1071.05;694.216;220.085;50.1592 2 10 2 259241;24426 NR1D2_9358;GSTP1_8762 21.96795 21.96795 10.18919658486379 6.392244999999999 6.392244999999999 4.295921183081692 69.8788 69.8788 62.45053954354597 29.1728;14.7631 3.35457;9.42992 114.038;25.7196 10 24832;295703;25682;25154;81687;25283;24854;24232;246142;29657 THY1_33010;SERPING1_32597;PPARD_9536;PGR_32824;MMP9_32531;GCLC_8699;CLU_32773;C3_8175;BMF_8152;ARNTL_8086 258.2863500000006 125.5505 319.08693957989675 170.41359000000057 60.87219999999999 259.39315300229475 627.3962700000005 308.647 707.643324145148 5.72311E-12;32.3997;94.1074;283.618;728.316;131.7;935.649;234.759;119.401;22.9134 5.72311E-12;13.7308;37.7692;138.711;443.137;39.9158;808.484;129.148;81.8286;11.4115 5.72313E-12;99.4885;148.485;1554.21;2039.06;397.209;1071.05;694.216;220.085;50.1592 0 Exp 4,4(0.34);Exp 5,1(0.09);Hill,2(0.17);Linear,1(0.09);Poly 2,4(0.34) 1.9943862163499613 24.945594310760498 1.5405861139297485 3.5281898975372314 0.6910671068340639 1.9010515809059143 47.492934773162716 390.3069652268382 5.4932889887367935 280.66010934459746 151.9161341684595 917.0372491648747 DOWN 0.16666666666666666 0.8333333333333334 0.0 GO:0071654 8 positive regulation of chemokine (C-C motif) ligand 1 production 1 1 1 1 1 1 1 1 67 0 2479 1.0 0.026698 0.026698 100.0 688621 tslp TSLP_32811 344.675 344.675 344.675 344.675 244.2 244.2 244.2 244.2 560.435 560.435 560.435 560.435 0.0 344.675 0.0 344.675 344.675 244.2 560.435 0 1 0 1 688621 TSLP_32811 344.675 344.675 244.2 244.2 560.435 560.435 344.675 244.2 560.435 0 Exp 2,1(1) 1.6858625411987305 1.6858625411987305 1.6858625411987305 1.6858625411987305 0.0 1.6858625411987305 344.675 344.675 244.2 244.2 560.435 560.435 DOWN 0.0 1.0 0.0 GO:0071657 8 positive regulation of granulocyte colony-stimulating factor production 1 1 1 1 1 1 1 1 67 0 2479 1.0 0.026698 0.026698 100.0 688621 tslp TSLP_32811 344.675 344.675 344.675 344.675 244.2 244.2 244.2 244.2 560.435 560.435 560.435 560.435 0.0 344.675 0.0 344.675 344.675 244.2 560.435 0 1 0 1 688621 TSLP_32811 344.675 344.675 244.2 244.2 560.435 560.435 344.675 244.2 560.435 0 Exp 2,1(1) 1.6858625411987305 1.6858625411987305 1.6858625411987305 1.6858625411987305 0.0 1.6858625411987305 344.675 344.675 244.2 244.2 560.435 560.435 DOWN 0.0 1.0 0.0 GO:0032870 5 cellular response to hormone stimulus 198 212 18 18 10 15 10 10 58 202 2277 0.97738 0.051851 0.070228 4.72 288583;25154;362282;24426;25283;25315;114494;25612;29221;170913 plod3;pgr;pck1;gstp1;gclc;ephx1;ccna2;asns;arg1;abcb1a PLOD3_9507;PGR_32824;PCK1_9439;GSTP1_8762;GCLC_8699;EPHX1_8567;CCNA2_8221;ASNS_8091;ARG1_33267;ABCB1A_7938 305.46302000000003 199.0635 14.384 313.4384562970706 240.71719599402294 271.08545571297765 183.966341 115.7945 4.89199 210.71433291238787 133.23304355395877 169.6111809989521 892.5912500000001 765.6635 25.7196 847.0847541054452 843.8218482716944 884.2279432014035 882.629;283.618;529.244;14.7631;131.7;39.2381;14.384;191.145;760.927;206.982 625.677;138.711;356.883;9.42992;39.9158;18.9587;4.89199;113.564;413.607;118.025 1106.02;1554.21;1021.06;25.7196;397.209;81.6965;58.2504;510.267;2639.93;1531.55 3 7 3 362282;24426;25315 PCK1_9439;GSTP1_8762;EPHX1_8567 194.4150666666667 39.2381 290.22847440267356 128.42387333333332 18.9587 197.9087639040882 376.15869999999995 81.6965 559.2017689436166 529.244;14.7631;39.2381 356.883;9.42992;18.9587 1021.06;25.7196;81.6965 7 288583;25154;25283;114494;25612;29221;170913 PLOD3_9507;PGR_32824;GCLC_8699;CCNA2_8221;ASNS_8091;ARG1_33267;ABCB1A_7938 353.05499999999995 206.982 332.38480172936113 207.77025571428572 118.025 226.5861615216687 1113.9194857142859 1106.02 884.0766310481148 882.629;283.618;131.7;14.384;191.145;760.927;206.982 625.677;138.711;39.9158;4.89199;113.564;413.607;118.025 1106.02;1554.21;397.209;58.2504;510.267;2639.93;1531.55 0 Exp 2,1(0.1);Exp 4,3(0.3);Hill,1(0.1);Linear,1(0.1);Poly 2,4(0.4) 1.865392077352435 19.25265634059906 1.513624906539917 3.5281898975372314 0.5917541966594053 1.7607250213623047 111.19185207556572 499.7341879244343 53.36424438135913 314.56843761864087 367.5626799413326 1417.619820058667 DOWN 0.3 0.7 0.0 GO:1901362 5 organic cyclic compound biosynthetic process 212 234 12 12 8 9 7 7 61 227 2252 0.71641 0.43554 0.67192 2.99 25682;299112;300795;64191;312495;24296;113902 ppard;pole2;pclaf;dhcr7;cyp26b1;cyp1a1;ces1d PPARD_9536;POLE2_9520;NS5ATP9_9367;DHCR7_8466;CYP26B1_8418;CYP1A1_8415;CES1D_32914 84.309614324514 18.1872 2.71598E-7 108.97743892813467 76.04842616301399 92.17764632864531 37.07504146737114 10.0176 2.71598E-7 52.21463342533628 29.451812588129194 38.809344770394176 194.51470003879987 36.7271 2.71599E-7 266.0457915706242 193.19280938882068 247.85867371153202 94.1074;2.71598E-7;292.216;161.702;18.1872;12.8863;11.0684 37.7692;2.71598E-7;147.515;50.9087;10.0176;9.13136;4.18343 148.485;2.71599E-7;658.494;481.517;36.7271;19.3234;17.0564 2 5 2 312495;24296 CYP26B1_8418;CYP1A1_8415 15.536750000000001 15.536750000000001 3.7483023363917627 9.574480000000001 9.574480000000001 0.6266663137587598 28.02525 28.02525 12.306274287736318 18.1872;12.8863 10.0176;9.13136 36.7271;19.3234 5 25682;299112;300795;64191;113902 PPARD_9536;POLE2_9520;NS5ATP9_9367;DHCR7_8466;CES1D_32914 111.8187600543196 94.1074 120.41518194655993 48.0752660543196 37.7692 59.666214235794335 261.1104800543198 148.485 294.49884183132764 94.1074;2.71598E-7;292.216;161.702;11.0684 37.7692;2.71598E-7;147.515;50.9087;4.18343 148.485;2.71599E-7;658.494;481.517;17.0564 0 Exp 2,1(0.15);Exp 4,3(0.43);Exp 5,2(0.29);Hill,1(0.15) 2.431946914722952 26.25169825553894 1.6269687414169312 15.48720932006836 5.178316475082361 1.7927976846694946 3.5779977867533717 165.0412308622746 -1.6061002883441802 75.75618322308647 -2.574780479534951 391.60418055713455 DOWN 0.2857142857142857 0.7142857142857143 0.0 GO:0002697 5 regulation of immune effector process 103 117 7 7 4 5 3 3 65 114 2365 0.6187 0.61282 1.0 2.56 295703;24232;29221 serping1;c3;arg1 SERPING1_32597;C3_8175;ARG1_33267 342.69523333333336 234.759 32.3997 376.0660574433212 431.0075593475073 402.15112182063865 185.49526666666668 129.148 13.7308 205.80695973949312 233.4867857771261 220.03609157469688 1144.5448333333334 694.216 99.4885 1328.7429387692275 1464.7906035557185 1421.4120963949595 32.3997;234.759;760.927 13.7308;129.148;413.607 99.4885;694.216;2639.93 0 3 0 3 295703;24232;29221 SERPING1_32597;C3_8175;ARG1_33267 342.69523333333336 234.759 376.0660574433212 185.49526666666668 129.148 205.80695973949312 1144.5448333333334 694.216 1328.7429387692275 32.3997;234.759;760.927 13.7308;129.148;413.607 99.4885;694.216;2639.93 0 Exp 2,1(0.34);Exp 4,1(0.34);Poly 2,1(0.34) 1.590431468695412 4.778703331947327 1.513624906539917 1.7183171510696411 0.10986988720200842 1.5467612743377686 -82.86357208271284 768.2540387493796 -47.39723240245522 418.38776573578855 -359.06934969583335 2648.1590163625 DOWN 0.0 1.0 0.0 GO:0071478 5 cellular response to radiation 59 61 5 5 5 2 2 2 66 59 2420 0.77857 0.48934 0.67744 3.28 361921;246142 ect2;bmf ECT2_8523;BMF_8152 64.7086 64.7086 10.0162 77.34673383873424 67.88242626025792 77.21639002996315 42.561325 42.561325 3.29405 55.53231286243397 44.840023842321216 55.438730460060654 128.90775 128.90775 37.7305 128.9441035298823 134.19880964243845 128.72680843882253 10.0162;119.401 3.29405;81.8286 37.7305;220.085 0 2 0 2 361921;246142 ECT2_8523;BMF_8152 64.7086 64.7086 77.34673383873424 42.561325 42.561325 55.53231286243397 128.90775 128.90775 128.9441035298823 10.0162;119.401 3.29405;81.8286 37.7305;220.085 0 Exp 4,1(0.5);Poly 2,1(0.5) 1.619529337845824 3.239221215248108 1.6033858060836792 1.6358354091644287 0.022945334385209862 1.619610607624054 -42.48850399999999 171.90570400000001 -34.40253399999999 119.52518399999998 -49.79965999999999 307.61515999999995 DOWN 0.0 1.0 0.0 GO:0046165 5 alcohol biosynthetic process 38 41 5 5 5 5 5 5 63 36 2443 0.99938 0.0041589 0.0041589 12.2 362282;25315;64191;312495;113902 pck1;ephx1;dhcr7;cyp26b1;ces1d PCK1_9439;EPHX1_8567;DHCR7_8466;CYP26B1_8418;CES1D_32914 151.88794000000001 39.2381 11.0684 219.59617993421014 107.30984739372023 134.69444080776864 88.19028599999999 18.9587 4.18343 151.2835288480672 46.43951925471863 85.2417118744431 327.6114 81.6965 17.0564 431.8825409202194 277.3332267992591 306.1169443004011 1.5 28.712650000000004 3.5 345.473 529.244;39.2381;161.702;18.1872;11.0684 356.883;18.9587;50.9087;10.0176;4.18343 1021.06;81.6965;481.517;36.7271;17.0564 3 2 3 362282;25315;312495 PCK1_9439;EPHX1_8567;CYP26B1_8418 195.55643333333333 39.2381 289.17352784901203 128.61976666666666 18.9587 197.73230283932702 379.8278666666667 81.6965 555.7783266271754 529.244;39.2381;18.1872 356.883;18.9587;10.0176 1021.06;81.6965;36.7271 2 64191;113902 DHCR7_8466;CES1D_32914 86.3852 86.3852 106.51404003454194 27.546065000000002 27.546065000000002 33.03975526977236 249.2867 249.2867 328.4232398539726 161.702;11.0684 50.9087;4.18343 481.517;17.0564 0 Exp 4,3(0.6);Exp 5,1(0.2);Linear,1(0.2) 1.8228500075623821 9.16994595527649 1.611412525177002 2.090334892272949 0.22682232238301897 1.7927976846694946 -40.59659848541028 344.3724784854103 -44.41557371708882 220.79614571708885 -50.95033815883443 706.1731381588345 UP 0.6 0.4 0.0 GO:0044093 4 positive regulation of molecular function 417 443 24 22 12 13 8 8 60 435 2044 0.13853 0.92578 0.2574 1.81 24832;363131;81687;361921;24854;29397;686019;170913 thy1;pik3r4;mmp9;ect2;clu;ccl11;casq1;abcb1a THY1_33010;PIK3R4_9484;MMP9_32531;ECT2_8523;CLU_32773;CCL11_33230;CASQ1_32992;ABCB1A_7938 496.3409000000008 467.649 5.72311E-12 444.99663820575313 416.6441841304709 413.6141319263456 344.71804375000073 280.581 5.72311E-12 331.44397370684214 276.3637225659482 294.30703750166685 1060.6241875000007 1180.01 5.72313E-12 876.0658529046575 1023.9535802472026 904.0383979029614 5.72311E-12;955.628;728.316;10.0162;935.649;986.476;147.66;206.982 5.72311E-12;735.228;443.137;3.29405;808.484;552.974;96.6023;118.025 5.72313E-12;1288.97;2039.06;37.7305;1071.05;2230.86;285.773;1531.55 1 7 1 29397 CCL11_33230 986.476 986.476 552.974 552.974 2230.86 2230.86 986.476 552.974 2230.86 7 24832;363131;81687;361921;24854;686019;170913 THY1_33010;PIK3R4_9484;MMP9_32531;ECT2_8523;CLU_32773;CASQ1_32992;ABCB1A_7938 426.32160000000084 206.982 430.42667266359376 314.9671928571437 118.025 346.2704672002625 893.4476428571436 1071.05 796.5918877704722 5.72311E-12;955.628;728.316;10.0162;935.649;147.66;206.982 5.72311E-12;735.228;443.137;3.29405;808.484;96.6023;118.025 5.72313E-12;1288.97;2039.06;37.7305;1071.05;285.773;1531.55 0 Exp 4,1(0.13);Hill,1(0.13);Linear,1(0.13);Poly 2,4(0.5);Power,1(0.13) 1.832336015685532 14.8031325340271 1.5018656253814697 2.327066659927368 0.27804663217097914 1.875340223312378 187.97396232910603 804.7078376708955 115.03908798630735 574.3969995136941 453.541524252238 1667.7068507477634 DOWN 0.125 0.875 0.0 GO:0032570 5 response to progesterone 36 40 3 3 2 3 2 2 66 38 2441 0.91077 0.28964 0.28964 5.0 25154;24232 pgr;c3 PGR_32824;C3_8175 259.1885 259.1885 234.759 34.54853022199364 258.9855971760797 34.547338557233424 133.92950000000002 133.92950000000002 129.148 6.762062148486869 133.8897865448505 6.761828908140475 1124.213 1124.213 694.216 608.1075891797441 1120.641596345515 608.0866140360877 1.0 283.618 283.618;234.759 138.711;129.148 1554.21;694.216 0 2 0 2 25154;24232 PGR_32824;C3_8175 259.1885 259.1885 34.54853022199364 133.92950000000002 133.92950000000002 6.762062148486869 1124.213 1124.213 608.1075891797441 283.618;234.759 138.711;129.148 1554.21;694.216 0 Poly 2,2(1) 1.5436706063176329 3.087347388267517 1.5405861139297485 1.5467612743377686 0.004366497799425643 1.5436736941337585 211.30667999999997 307.07032 124.55776 143.30124000000004 281.4188800000002 1967.0071199999998 DOWN 0.0 1.0 0.0 GO:0048583 4 regulation of response to stimulus 781 832 54 52 32 33 25 25 43 807 1672 0.80653 0.2715 0.51241 3.0 688621;24832;295703;25682;338475;259241;316351;81687;24426;156275;25283;24367;29243;312495;245920;84032;24854;29397;24232;246142;29657;29221;81639;252898;170913 tslp;thy1;serping1;ppard;nrep;nr1d2;npas2;mmp9;gstp1;ggt7;gclc;fgg;f10;cyp26b1;cxcl10;col3a1;clu;ccl11;c3;bmf;arntl;arg1;alox15;acox2;abcb1a TSLP_32811;THY1_33010;SERPING1_32597;PPARD_9536;NREP_9364;NR1D2_9358;NPAS2_9350;MMP9_32531;GSTP1_8762;GGT7_33026;GCLC_8699;FGG_8639;F10_8585;CYP26B1_8418;CXCL10_8408;COL3A1_8354;CLU_32773;CCL11_33230;C3_8175;BMF_8152;ARNTL_8086;ARG1_33267;ALOX15_8036;ACOX2_32902;ABCB1A_7938 295.7049040000002 119.401 5.72311E-12 335.1913313553635 291.0529676056584 329.84082019484987 175.62525160000024 39.9158 5.72311E-12 221.64073310727116 171.91725834343762 216.05155842207668 842.9753280000003 346.073 5.72313E-12 946.2433454646695 828.8401257186163 943.7388767831811 344.675;5.72311E-12;32.3997;94.1074;61.543;29.1728;21.0878;728.316;14.7631;109.609;131.7;42.4612;104.19;18.1872;670.528;212.603;935.649;986.476;234.759;119.401;22.9134;760.927;766.819;743.353;206.982 244.2;5.72311E-12;13.7308;37.7692;25.6719;3.35457;11.3305;443.137;9.42992;29.3336;39.9158;20.6424;38.4229;10.0176;374.802;119.81;808.484;552.974;129.148;81.8286;11.4115;413.607;421.048;432.537;118.025 560.435;5.72313E-12;99.4885;148.485;148.788;114.038;43.5624;2039.06;25.7196;346.073;397.209;98.0534;163.044;36.7271;1955.3;1510.69;1071.05;2230.86;694.216;220.085;50.1592;2639.93;2662.07;2287.79;1531.55 4 21 4 259241;24426;312495;29397 NR1D2_9358;GSTP1_8762;CYP26B1_8418;CCL11_33230 262.149775 23.68 482.92327067250466 143.94402250000002 9.723759999999999 272.70328629173093 601.836175 75.38255 1086.726622567063 29.1728;14.7631;18.1872;986.476 3.35457;9.42992;10.0176;552.974 114.038;25.7196;36.7271;2230.86 21 688621;24832;295703;25682;338475;316351;81687;156275;25283;24367;29243;245920;84032;24854;24232;246142;29657;29221;81639;252898;170913 TSLP_32811;THY1_33010;SERPING1_32597;PPARD_9536;NREP_9364;NPAS2_9350;MMP9_32531;GGT7_33026;GCLC_8699;FGG_8639;F10_8585;CXCL10_8408;COL3A1_8354;CLU_32773;C3_8175;BMF_8152;ARNTL_8086;ARG1_33267;ALOX15_8036;ACOX2_32902;ABCB1A_7938 302.0963571428574 131.7 315.55278321067044 181.6597714285717 81.8286 218.07223316403912 888.9065952380955 397.209 939.9259365378147 344.675;5.72311E-12;32.3997;94.1074;61.543;21.0878;728.316;109.609;131.7;42.4612;104.19;670.528;212.603;935.649;234.759;119.401;22.9134;760.927;766.819;743.353;206.982 244.2;5.72311E-12;13.7308;37.7692;25.6719;11.3305;443.137;29.3336;39.9158;20.6424;38.4229;374.802;119.81;808.484;129.148;81.8286;11.4115;413.607;421.048;432.537;118.025 560.435;5.72313E-12;99.4885;148.485;148.788;43.5624;2039.06;346.073;397.209;98.0534;163.044;1955.3;1510.69;1071.05;694.216;220.085;50.1592;2639.93;2662.07;2287.79;1531.55 0 Exp 2,5(0.2);Exp 4,9(0.36);Exp 5,2(0.08);Hill,2(0.08);Linear,1(0.04);Poly 2,5(0.2);Power,1(0.04) 1.9421264492544996 50.206453800201416 1.5021449327468872 3.5281898975372314 0.5856821715361382 1.863204002380371 164.30990210869774 427.0999058913027 88.7420842219499 262.50841897805054 472.0479365778496 1213.9027194221505 DOWN 0.16 0.84 0.0 GO:0060763 5 mammary duct terminal end bud growth 2 2 1 1 1 1 1 1 67 1 2478 0.9993 0.052694 0.052694 50.0 29397 ccl11 CCL11_33230 986.476 986.476 986.476 986.476 552.974 552.974 552.974 552.974 2230.86 2230.86 2230.86 2230.86 0.0 986.476 0.0 986.476 986.476 552.974 2230.86 1 0 1 29397 CCL11_33230 986.476 986.476 552.974 552.974 2230.86 2230.86 986.476 552.974 2230.86 0 0 Power,1(1) 1.9814788103103638 1.9814788103103638 1.9814788103103638 1.9814788103103638 0.0 1.9814788103103638 986.476 986.476 552.974 552.974 2230.86 2230.86 UP 1.0 0.0 0.0 GO:0001936 7 regulation of endothelial cell proliferation 43 44 8 7 3 6 3 3 65 41 2438 0.97172 0.11108 0.11108 6.82 81919;29397;29221 fut1;ccl11;arg1 FUT1_8668;CCL11_33230;ARG1_33267 662.7546666666667 760.927 240.861 382.37911466283464 591.5506731172126 395.4360399228464 348.51786666666675 413.607 78.9726 243.6119419467225 303.0859837358033 252.14878993286433 1906.22 2230.86 847.87 939.1022884116511 1739.9348577571945 988.9265962871748 1.5 873.7015 240.861;986.476;760.927 78.9726;552.974;413.607 847.87;2230.86;2639.93 1 2 1 29397 CCL11_33230 986.476 986.476 552.974 552.974 2230.86 2230.86 986.476 552.974 2230.86 2 81919;29221 FUT1_8668;ARG1_33267 500.894 500.894 367.742195264563 246.2898 246.2898 236.6222534582916 1743.8999999999999 1743.8999999999999 1267.1777782931645 240.861;760.927 78.9726;413.607 847.87;2639.93 0 Exp 2,2(0.67);Power,1(0.34) 2.0172572505131177 6.232112288475037 1.513624906539917 2.737008571624756 0.6173032868184868 1.9814788103103638 230.05196449183296 1095.4573688415005 72.84500295560105 624.1907303777323 843.5257203383217 2968.9142796616784 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0010564 6 regulation of cell cycle process 146 156 9 9 7 6 5 5 63 151 2328 0.76529 0.40459 0.60649 3.21 315852;363131;291234;361921;24296 ttk;pik3r4;mki67;ect2;cyp1a1 TTK_32727;PIK3R4_9484;MKI67_9232;ECT2_8523;CYP1A1_8415 347.56252000000006 21.9311 10.0162 461.9686675464549 238.21921097608782 403.1314644907007 240.22098999999997 9.13136 3.29405 336.0224384528968 156.1036659270874 279.54141072066017 706.05866 76.1794 19.3234 951.3796872959282 555.050911760094 935.034694198004 737.351;955.628;21.9311;10.0162;12.8863 446.625;735.228;6.82654;3.29405;9.13136 2108.09;1288.97;76.1794;37.7305;19.3234 1 4 1 24296 CYP1A1_8415 12.8863 12.8863 9.13136 9.13136 19.3234 19.3234 12.8863 9.13136 19.3234 4 315852;363131;291234;361921 TTK_32727;PIK3R4_9484;MKI67_9232;ECT2_8523 431.231575 379.64105 487.7328448671901 297.9933975 226.72577 358.18584338692204 877.742475 682.5747 1005.1511645747797 737.351;955.628;21.9311;10.0162 446.625;735.228;6.82654;3.29405 2108.09;1288.97;76.1794;37.7305 0 Exp 4,3(0.6);Linear,1(0.2);Poly 2,1(0.2) 2.562613470690051 22.058106541633606 1.5018656253814697 15.48720932006836 6.193767626990804 1.6358354091644287 -57.370870890678646 752.4959108906787 -54.31566362359919 534.7576436235993 -127.86240405682577 1539.979724056826 DOWN 0.2 0.8 0.0 GO:0060255 5 regulation of macromolecule metabolic process 1000 1070 61 58 39 33 25 25 43 1045 1434 0.2234 0.84448 0.38701 2.34 688621;360243;24832;25671;295703;25682;25154;362282;304545;259241;316351;81687;24426;25283;24367;361921;312495;24854;306575;114494;29397;24232;29657;29221;81639 tslp;top2a;thy1;smad1;serping1;ppard;pgr;pck1;oasl;nr1d2;npas2;mmp9;gstp1;gclc;fgg;ect2;cyp26b1;clu;ckap2;ccna2;ccl11;c3;arntl;arg1;alox15 TSLP_32811;TOP2A_10059;THY1_33010;SMAD1_32578;SERPING1_32597;PPARD_9536;PGR_32824;PCK1_9439;OASL_9389;NR1D2_9358;NPAS2_9350;MMP9_32531;GSTP1_8762;GCLC_8699;FGG_8639;ECT2_8523;CYP26B1_8418;CLU_32773;CKAP2_8324;CCNA2_8221;CCL11_33230;C3_8175;ARNTL_8086;ARG1_33267;ALOX15_8036 248.75650400000023 76.6126 5.72311E-12 327.8771133225047 250.20698639626653 332.3002110751718 149.97627960000023 26.6888 5.72311E-12 220.85575883788923 147.81619399838362 218.59270017608074 650.4730960000002 148.485 5.72313E-12 875.267785718291 660.2669505084126 909.1330076844602 344.675;86.3883;5.72311E-12;21.9973;32.3997;94.1074;283.618;529.244;76.6126;29.1728;21.0878;728.316;14.7631;131.7;42.4612;10.0162;18.1872;935.649;32.2386;14.384;986.476;234.759;22.9134;760.927;766.819 244.2;26.6888;5.72311E-12;5.02186;13.7308;37.7692;138.711;356.883;28.4477;3.35457;11.3305;443.137;9.42992;39.9158;20.6424;3.29405;10.0176;808.484;15.2683;4.89199;552.974;129.148;11.4115;413.607;421.048 560.435;262.273;5.72313E-12;80.1461;99.4885;148.485;1554.21;1021.06;260.389;114.038;43.5624;2039.06;25.7196;397.209;98.0534;37.7305;36.7271;1071.05;76.7052;58.2504;2230.86;694.216;50.1592;2639.93;2662.07 5 20 5 362282;259241;24426;312495;29397 PCK1_9439;NR1D2_9358;GSTP1_8762;CYP26B1_8418;CCL11_33230 315.56862 29.1728 434.9471565873744 186.53181800000002 10.0176 254.64468066991193 685.68094 114.038 959.6253369083885 529.244;29.1728;14.7631;18.1872;986.476 356.883;3.35457;9.42992;10.0176;552.974 1021.06;114.038;25.7196;36.7271;2230.86 20 688621;360243;24832;25671;295703;25682;25154;304545;316351;81687;25283;24367;361921;24854;306575;114494;24232;29657;29221;81639 TSLP_32811;TOP2A_10059;THY1_33010;SMAD1_32578;SERPING1_32597;PPARD_9536;PGR_32824;OASL_9389;NPAS2_9350;MMP9_32531;GCLC_8699;FGG_8639;ECT2_8523;CLU_32773;CKAP2_8324;CCNA2_8221;C3_8175;ARNTL_8086;ARG1_33267;ALOX15_8036 232.0534750000003 81.50045 307.4056466886705 140.8373950000003 27.56825 217.99647683506265 641.6711350000003 204.437 879.4429493030502 344.675;86.3883;5.72311E-12;21.9973;32.3997;94.1074;283.618;76.6126;21.0878;728.316;131.7;42.4612;10.0162;935.649;32.2386;14.384;234.759;22.9134;760.927;766.819 244.2;26.6888;5.72311E-12;5.02186;13.7308;37.7692;138.711;28.4477;11.3305;443.137;39.9158;20.6424;3.29405;808.484;15.2683;4.89199;129.148;11.4115;413.607;421.048 560.435;262.273;5.72313E-12;80.1461;99.4885;148.485;1554.21;260.389;43.5624;2039.06;397.209;98.0534;37.7305;1071.05;76.7052;58.2504;694.216;50.1592;2639.93;2662.07 0 Exp 2,3(0.12);Exp 4,13(0.52);Exp 5,1(0.04);Hill,2(0.08);Linear,2(0.08);Poly 2,3(0.12);Power,1(0.04) 1.954591605498946 50.49631404876709 1.5021449327468872 3.5281898975372314 0.5820351013847176 1.8927439451217651 120.22867557757846 377.28433242242215 63.40082213554767 236.55173706445282 307.3681239984303 993.5780680015703 DOWN 0.2 0.8 0.0 GO:0009266 4 response to temperature stimulus 80 87 10 10 7 8 6 6 62 81 2398 0.99241 0.026782 0.026782 6.9 116669;81687;291234;25283;245920;686019 vwf;mmp9;mki67;gclc;cxcl10;casq1 VWF_32396;MMP9_32531;MKI67_9232;GCLC_8699;CXCL10_8408;CASQ1_32992 286.63525 139.68 19.6764 324.6875097224392 215.5367949109414 284.3793263092848 160.9000133333333 68.25905 4.11644 196.2156346525802 120.27179961432917 176.5264792011124 807.9332333333333 341.491 76.1794 929.3570126417115 593.6731866187695 802.1769670402039 3.5 409.094 19.6764;728.316;21.9311;131.7;670.528;147.66 4.11644;443.137;6.82654;39.9158;374.802;96.6023 94.078;2039.06;76.1794;397.209;1955.3;285.773 0 6 0 6 116669;81687;291234;25283;245920;686019 VWF_32396;MMP9_32531;MKI67_9232;GCLC_8699;CXCL10_8408;CASQ1_32992 286.63525 139.68 324.6875097224392 160.9000133333333 68.25905 196.2156346525802 807.9332333333333 341.491 929.3570126417115 19.6764;728.316;21.9311;131.7;670.528;147.66 4.11644;443.137;6.82654;39.9158;374.802;96.6023 94.078;2039.06;76.1794;397.209;1955.3;285.773 0 Exp 2,1(0.17);Exp 4,1(0.17);Hill,2(0.34);Linear,1(0.17);Poly 2,1(0.17) 2.0312555262213303 12.220237374305725 1.8538048267364502 2.327066659927368 0.16610223284619155 2.0130178332328796 26.83113327285679 546.4393667271431 3.894806411305666 317.905220255361 64.29274651583353 1551.5737201508332 DOWN 0.0 1.0 0.0 GO:0098869 4 cellular oxidant detoxification 38 46 6 6 4 2 2 2 66 44 2435 0.87729 0.34927 0.34927 4.35 24314;24426 nqo1;gstp1 NQO1_33055;GSTP1_8762 20.2222 20.2222 14.7631 7.720333258350962 22.348154985590778 7.110849205157095 8.584679999999999 8.584679999999999 7.73944 1.1953498714602508 8.255515450528339 1.1009826129155138 55.92035 55.92035 25.7196 42.710310243839245 67.68152584053796 39.33853183357117 25.6813;14.7631 7.73944;9.42992 86.1211;25.7196 2 0 2 24314;24426 NQO1_33055;GSTP1_8762 20.2222 20.2222 7.720333258350962 8.584679999999999 8.584679999999999 1.1953498714602508 55.92035 55.92035 42.710310243839245 25.6813;14.7631 7.73944;9.42992 86.1211;25.7196 0 0 Exp 4,1(0.5);Hill,1(0.5) 2.7687489018727516 5.700967073440552 2.1727771759033203 3.5281898975372314 0.9584215267738528 2.850483536720276 9.522364 30.922036000000002 6.9280096 10.241350399999998 -3.2731199999999845 115.11381999999998 UP 1.0 0.0 0.0 GO:0007088 7 regulation of mitotic nuclear division 43 46 3 3 3 2 2 2 66 44 2435 0.87729 0.34927 0.34927 4.35 315852;291234 ttk;mki67 TTK_32727;MKI67_9232 379.64105 379.64105 21.9311 505.87826268580164 342.31090044383745 503.1160269025765 226.72577 226.72577 6.82654 310.9844734214006 203.77736964606805 309.2864118443892 1092.1347 1092.1347 76.1794 1436.7777640248266 986.1109137134404 1428.9325584782173 737.351;21.9311 446.625;6.82654 2108.09;76.1794 0 2 0 2 315852;291234 TTK_32727;MKI67_9232 379.64105 379.64105 505.87826268580164 226.72577 226.72577 310.9844734214006 1092.1347 1092.1347 1436.7777640248266 737.351;21.9311 446.625;6.82654 2108.09;76.1794 0 Exp 4,1(0.5);Linear,1(0.5) 1.7042599443315567 3.433196187019348 1.5111545324325562 1.922041654586792 0.29054107037748544 1.716598093509674 -321.47045199999985 1080.752552 -204.27672079999985 657.7282607999998 -899.137688 3083.407088 DOWN 0.0 1.0 0.0 GO:0031329 6 regulation of cellular catabolic process 171 183 8 8 6 5 3 3 65 180 2299 0.26744 0.8783 0.48029 1.64 25283;24854;246142 gclc;clu;bmf GCLC_8699;CLU_32773;BMF_8152 395.5833333333333 131.7 119.401 467.7510123819438 285.93325759570587 394.7368358374421 310.0761333333333 81.8286 39.9158 432.1423051118386 206.98374752886366 366.1074376841731 562.7813333333334 397.209 220.085 448.9944386964423 465.49291629532104 380.374200413611 131.7;935.649;119.401 39.9158;808.484;81.8286 397.209;1071.05;220.085 0 3 0 3 25283;24854;246142 GCLC_8699;CLU_32773;BMF_8152 395.5833333333333 131.7 467.7510123819438 310.0761333333333 81.8286 432.1423051118386 562.7813333333334 397.209 448.9944386964423 131.7;935.649;119.401 39.9158;808.484;81.8286 397.209;1071.05;220.085 0 Hill,1(0.34);Poly 2,2(0.67) 1.7011499535994954 5.132933974266052 1.5548590421676636 1.9746891260147095 0.22966580848085308 1.6033858060836792 -133.72676557503974 924.8934322417065 -178.93891998837557 799.0911866550423 54.69629564310304 1070.8663710235637 DOWN 0.0 1.0 0.0 GO:1901654 5 response to ketone 140 154 11 11 6 9 6 6 62 148 2331 0.88681 0.22584 0.30052 3.9 25154;362282;24232;29221;24646;170913 pgr;pck1;c3;arg1;abcb1b;abcb1a PGR_32824;PCK1_9439;C3_8175;ARG1_33267;ABCB1B_7939;ABCB1A_7938 339.38735 259.1885 20.7941 263.37477925901516 270.722373904209 294.63453575827606 194.10459166666666 133.92950000000002 8.25355 156.3935038542855 149.21270582002904 164.85708211859682 1249.69625 1276.3049999999998 57.2115 881.7905377019958 1127.702840348331 1048.8168868947948 283.618;529.244;234.759;760.927;20.7941;206.982 138.711;356.883;129.148;413.607;8.25355;118.025 1554.21;1021.06;694.216;2639.93;57.2115;1531.55 1 5 1 362282 PCK1_9439 529.244 529.244 356.883 356.883 1021.06 1021.06 529.244 356.883 1021.06 5 25154;24232;29221;24646;170913 PGR_32824;C3_8175;ARG1_33267;ABCB1B_7939;ABCB1A_7938 301.41602 234.759 275.48898103626937 161.54891000000003 129.148 150.41481640422097 1295.4235 1531.55 977.8858982681721 283.618;234.759;760.927;20.7941;206.982 138.711;129.148;413.607;8.25355;118.025 1554.21;694.216;2639.93;57.2115;1531.55 0 Exp 2,1(0.17);Hill,1(0.17);Linear,1(0.17);Poly 2,3(0.5) 2.01989826811671 14.290866494178772 1.513624906539917 6.191005229949951 1.8711790716367913 1.5790868997573853 128.64363536777108 550.131064632229 68.963725713862 319.2454576194713 544.1168700544612 1955.2756299455386 DOWN 0.16666666666666666 0.8333333333333334 0.0 GO:0048522 5 positive regulation of cellular process 1060 1140 76 74 50 50 37 37 31 1103 1376 0.95925 0.067304 0.10941 3.25 684352;688621;360243;24832;25671;25682;363131;25154;362282;259241;24314;316351;81687;24426;25283;81919;24367;309186;29243;361921;312495;24296;245920;84032;24854;306575;114494;29397;686019;24232;246142;25612;29657;29221;81639;252898;170913 twf2;tslp;top2a;thy1;smad1;ppard;pik3r4;pgr;pck1;nr1d2;nqo1;npas2;mmp9;gstp1;gclc;fut1;fgg;fermt3;f10;ect2;cyp26b1;cyp1a1;cxcl10;col3a1;clu;ckap2;ccna2;ccl11;casq1;c3;bmf;asns;arntl;arg1;alox15;acox2;abcb1a TWF2_10109;TSLP_32811;TOP2A_10059;THY1_33010;SMAD1_32578;PPARD_9536;PIK3R4_9484;PGR_32824;PCK1_9439;NR1D2_9358;NQO1_33055;NPAS2_9350;MMP9_32531;GSTP1_8762;GCLC_8699;FUT1_8668;FGG_8639;FERMT3_32542;F10_8585;ECT2_8523;CYP26B1_8418;CYP1A1_8415;CXCL10_8408;COL3A1_8354;CLU_32773;CKAP2_8324;CCNA2_8221;CCL11_33230;CASQ1_32992;C3_8175;BMF_8152;ASNS_8091;ARNTL_8086;ARG1_33267;ALOX15_8036;ACOX2_32902;ABCB1A_7938 281.576510810811 138.399 5.72311E-12 318.07305221902647 244.93849284671134 294.8702967049236 171.32097270270287 81.8286 5.72311E-12 217.2518646399718 143.83121695979642 195.44579615785358 759.3448216216218 299.165 5.72313E-12 842.3307550104942 681.5883014962371 821.2834666227371 138.399;344.675;86.3883;5.72311E-12;21.9973;94.1074;955.628;283.618;529.244;29.1728;25.6813;21.0878;728.316;14.7631;131.7;240.861;42.4612;539.113;104.19;10.0162;18.1872;12.8863;670.528;212.603;935.649;32.2386;14.384;986.476;147.66;234.759;119.401;191.145;22.9134;760.927;766.819;743.353;206.982 90.7363;244.2;26.6888;5.72311E-12;5.02186;37.7692;735.228;138.711;356.883;3.35457;7.73944;11.3305;443.137;9.42992;39.9158;78.9726;20.6424;334.248;38.4229;3.29405;10.0176;9.13136;374.802;119.81;808.484;15.2683;4.89199;552.974;96.6023;129.148;81.8286;113.564;11.4115;413.607;421.048;432.537;118.025 299.165;560.435;262.273;5.72313E-12;80.1461;148.485;1288.97;1554.21;1021.06;114.038;86.1211;43.5624;2039.06;25.7196;397.209;847.87;98.0534;1187.86;163.044;37.7305;36.7271;19.3234;1955.3;1510.69;1071.05;76.7052;58.2504;2230.86;285.773;694.216;220.085;510.267;50.1592;2639.93;2662.07;2287.79;1531.55 7 30 7 362282;259241;24314;24426;312495;24296;29397 PCK1_9439;NR1D2_9358;NQO1_33055;GSTP1_8762;CYP26B1_8418;CYP1A1_8415;CCL11_33230 230.91581428571428 25.6813 383.4502746171983 135.64712714285716 9.42992 225.3473349291568 504.8356 86.1211 842.4262838970759 529.244;29.1728;25.6813;14.7631;18.1872;12.8863;986.476 356.883;3.35457;7.73944;9.42992;10.0176;9.13136;552.974 1021.06;114.038;86.1211;25.7196;36.7271;19.3234;2230.86 30 684352;688621;360243;24832;25671;25682;363131;25154;316351;81687;25283;81919;24367;309186;29243;361921;245920;84032;24854;306575;114494;686019;24232;246142;25612;29657;29221;81639;252898;170913 TWF2_10109;TSLP_32811;TOP2A_10059;THY1_33010;SMAD1_32578;PPARD_9536;PIK3R4_9484;PGR_32824;NPAS2_9350;MMP9_32531;GCLC_8699;FUT1_8668;FGG_8639;FERMT3_32542;F10_8585;ECT2_8523;CXCL10_8408;COL3A1_8354;CLU_32773;CKAP2_8324;CCNA2_8221;CASQ1_32992;C3_8175;BMF_8152;ASNS_8091;ARNTL_8086;ARG1_33267;ALOX15_8036;ACOX2_32902;ABCB1A_7938 293.3973400000002 169.4025 307.2556283714952 179.6448700000002 93.66929999999999 218.41639352707853 818.7303066666668 453.738 845.3818497569868 138.399;344.675;86.3883;5.72311E-12;21.9973;94.1074;955.628;283.618;21.0878;728.316;131.7;240.861;42.4612;539.113;104.19;10.0162;670.528;212.603;935.649;32.2386;14.384;147.66;234.759;119.401;191.145;22.9134;760.927;766.819;743.353;206.982 90.7363;244.2;26.6888;5.72311E-12;5.02186;37.7692;735.228;138.711;11.3305;443.137;39.9158;78.9726;20.6424;334.248;38.4229;3.29405;374.802;119.81;808.484;15.2683;4.89199;96.6023;129.148;81.8286;113.564;11.4115;413.607;421.048;432.537;118.025 299.165;560.435;262.273;5.72313E-12;80.1461;148.485;1288.97;1554.21;43.5624;2039.06;397.209;847.87;98.0534;1187.86;163.044;37.7305;1955.3;1510.69;1071.05;76.7052;58.2504;285.773;694.216;220.085;510.267;50.1592;2639.93;2662.07;2287.79;1531.55 0 Exp 2,7(0.19);Exp 4,12(0.33);Exp 5,2(0.06);Hill,3(0.09);Linear,2(0.06);Poly 2,10(0.28);Power,1(0.03) 2.0239883050618084 86.39371633529663 1.5018656253814697 15.48720932006836 2.2834411534607 1.8538048267364502 179.0863709699043 384.0666506517177 101.31763909015952 241.3243063152463 487.92730834585257 1030.7623348973912 DOWN 0.1891891891891892 0.8108108108108109 0.0 GO:0090068 7 positive regulation of cell cycle process 80 86 3 3 2 2 2 2 66 84 2395 0.5948 0.67737 1.0 2.33 361921;24296 ect2;cyp1a1 ECT2_8523;CYP1A1_8415 11.45125 11.45125 10.0162 2.0294671726835136 11.002595405350213 1.9277331543549665 6.212705000000001 6.212705000000001 3.29405 4.127601484888046 5.300215556463141 3.920691271818986 28.52695 28.52695 19.3234 13.015785231978898 31.404351480498264 12.36332425543604 10.0162;12.8863 3.29405;9.13136 37.7305;19.3234 1 1 1 24296 CYP1A1_8415 12.8863 12.8863 9.13136 9.13136 19.3234 19.3234 12.8863 9.13136 19.3234 1 361921 ECT2_8523 10.0162 10.0162 3.29405 3.29405 37.7305 37.7305 10.0162 3.29405 37.7305 0 Exp 4,2(1) 5.033341374763804 17.123044729232788 1.6358354091644287 15.48720932006836 9.794400421150598 8.561522364616394 8.638551999999999 14.263948000000001 0.4921412000000007 11.933268799999999 10.487992000000006 46.56590799999999 CONFLICT 0.5 0.5 0.0 GO:0017144 4 drug metabolic process 142 165 8 8 5 6 4 4 64 161 2318 0.5467 0.65291 1.0 2.42 362282;84493;24296;25612 pck1;fmo3;cyp1a1;asns PCK1_9439;FMO3_8654;CYP1A1_8415;ASNS_8091 287.837075 304.609 12.8863 231.07429226655472 284.2177069846348 187.80913523854528 193.21708999999998 203.42700000000002 9.13136 160.2428242264192 191.8336729077602 135.12011608651952 565.7085999999999 611.2255 19.3234 420.48008200021394 551.2155188987446 308.4855203114478 529.244;418.073;12.8863;191.145 356.883;293.29;9.13136;113.564 1021.06;712.184;19.3234;510.267 2 2 2 362282;24296 PCK1_9439;CYP1A1_8415 271.06515 271.06515 365.1200311878889 183.00718 183.00718 245.897542812743 520.1917 520.1917 708.3347428227561 529.244;12.8863 356.883;9.13136 1021.06;19.3234 2 84493;25612 FMO3_8654;ASNS_8091 304.609 304.609 160.46232764110084 203.42700000000002 203.42700000000002 127.08547335553337 611.2255 611.2255 142.776879936844 418.073;191.145 293.29;113.564 712.184;510.267 0 Exp 2,1(0.25);Exp 4,1(0.25);Linear,1(0.25);Poly 2,1(0.25) 2.9915355852923016 20.681577801704407 1.611412525177002 15.48720932006836 6.878409725337669 1.7914779782295227 61.384268578776386 514.2898814212236 36.17912225810923 350.2550577418908 153.63811963979032 977.7790803602095 CONFLICT 0.5 0.5 0.0 GO:0015887 6 pantothenate transmembrane transport 1 1 1 1 1 1 1 1 67 0 2479 1.0 0.026698 0.026698 100.0 170551 slc5a6 SLC5A6_9881 120.077 120.077 120.077 120.077 82.2177 82.2177 82.2177 82.2177 221.286 221.286 221.286 221.286 0.0 120.077 0.0 120.077 120.077 82.2177 221.286 0 1 0 1 170551 SLC5A6_9881 120.077 120.077 82.2177 82.2177 221.286 221.286 120.077 82.2177 221.286 0 Poly 2,1(1) 1.517665982246399 1.517665982246399 1.517665982246399 1.517665982246399 0.0 1.517665982246399 120.077 120.077 82.2177 82.2177 221.286 221.286 DOWN 0.0 1.0 0.0 GO:0031668 4 cellular response to extracellular stimulus 98 103 15 15 11 10 7 7 61 96 2383 0.99464 0.018367 0.018367 6.8 363131;362282;81687;24426;246142;25612;170913 pik3r4;pck1;mmp9;gstp1;bmf;asns;abcb1a PIK3R4_9484;PCK1_9439;MMP9_32531;GSTP1_8762;BMF_8152;ASNS_8091;ABCB1A_7938 392.2113 206.982 14.7631 351.38128913232794 324.2720780506799 306.80104799558416 265.44221714285715 118.025 9.42992 259.7083684443496 206.92601092553764 209.7907753111811 948.1016571428572 1021.06 25.7196 733.0998477923426 968.4109464086744 798.318304143084 4.5 628.78 955.628;529.244;728.316;14.7631;119.401;191.145;206.982 735.228;356.883;443.137;9.42992;81.8286;113.564;118.025 1288.97;1021.06;2039.06;25.7196;220.085;510.267;1531.55 2 5 2 362282;24426 PCK1_9439;GSTP1_8762 272.00355 272.00355 363.7929331809581 183.15645999999998 183.15645999999998 245.686429012152 523.3897999999999 523.3897999999999 703.8119464289307 529.244;14.7631 356.883;9.42992 1021.06;25.7196 5 363131;81687;246142;25612;170913 PIK3R4_9484;MMP9_32531;BMF_8152;ASNS_8091;ABCB1A_7938 440.29440000000005 206.982 376.8314726217809 298.35652 118.025 285.20613164841313 1117.9864000000002 1288.97 745.6870343162068 955.628;728.316;119.401;191.145;206.982 735.228;443.137;81.8286;113.564;118.025 1288.97;2039.06;220.085;510.267;1531.55 0 Exp 4,1(0.15);Linear,2(0.29);Poly 2,4(0.58) 1.918616536559246 13.989058017730713 1.5018656253814697 3.5281898975372314 0.7005905439963539 1.805381178855896 131.9043982064817 652.5182017935184 73.04756537715366 457.8368689085605 405.0136897802612 1491.1896245054531 DOWN 0.2857142857142857 0.7142857142857143 0.0 GO:0050768 7 negative regulation of neurogenesis 70 74 4 4 3 3 3 3 65 71 2408 0.86678 0.3164 0.44745 4.05 24832;84032;29397 thy1;col3a1;ccl11 THY1_33010;COL3A1_8354;CCL11_33230 399.69300000000186 212.603 5.72311E-12 519.168301920483 493.4156947280508 553.4100810658807 224.26133333333527 119.81 5.72311E-12 290.90827067192856 276.73739075552436 310.10214661052345 1247.1833333333352 1510.69 5.72313E-12 1138.534543803273 1360.641072025248 1178.2064762408204 5.72311E-12;212.603;986.476 5.72311E-12;119.81;552.974 5.72313E-12;1510.69;2230.86 1 2 1 29397 CCL11_33230 986.476 986.476 552.974 552.974 2230.86 2230.86 986.476 552.974 2230.86 2 24832;84032 THY1_33010;COL3A1_8354 106.30150000000286 106.30150000000286 150.33302300059952 59.905000000002865 59.905000000002865 84.71846345395622 755.3450000000029 755.3450000000029 1068.2191432707016 5.72311E-12;212.603 5.72311E-12;119.81 5.72313E-12;1510.69 0 Hill,1(0.34);Poly 2,1(0.34);Power,1(0.34) 1.8125643502242548 5.457668304443359 1.6129854917526245 1.9814788103103638 0.1881424810586115 1.863204002380371 -187.8012393822811 987.1872393822849 -104.93236469524066 553.4550313619111 -41.18978834581935 2535.55645501249 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0060627 5 regulation of vesicle-mediated transport 135 149 8 8 5 6 4 4 64 145 2334 0.63355 0.57055 1.0 2.68 24367;24854;24232;81639 fgg;clu;c3;alox15 FGG_8639;CLU_32773;C3_8175;ALOX15_8036 494.92205 500.789 42.4612 424.4894302742334 459.077644113444 442.5264421102844 344.8306 275.098 20.6424 352.32586259329116 314.2600136308673 351.26639594259456 1131.34735 882.633 98.0534 1096.2858212922806 1092.4497798724854 1195.8343385021294 42.4612;935.649;234.759;766.819 20.6424;808.484;129.148;421.048 98.0534;1071.05;694.216;2662.07 0 4 0 4 24367;24854;24232;81639 FGG_8639;CLU_32773;C3_8175;ALOX15_8036 494.92205 500.789 424.4894302742334 344.8306 275.098 352.32586259329116 1131.34735 882.633 1096.2858212922806 42.4612;935.649;234.759;766.819 20.6424;808.484;129.148;421.048 98.0534;1071.05;694.216;2662.07 0 Exp 2,1(0.25);Exp 4,1(0.25);Poly 2,2(0.5) 1.786190778017702 7.421403408050537 1.5021449327468872 2.8176381587982178 0.6419434392110859 1.550810158252716 78.92240833125118 910.9216916687488 -0.44874534142525135 690.1099453414254 56.98724513356501 2205.707454866435 DOWN 0.0 1.0 0.0 GO:0015748 6 organophosphate ester transport 28 28 3 3 3 3 3 3 65 25 2454 0.99413 0.037024 0.037024 10.71 89776;24646;170913 slc22a7;abcb1b;abcb1a SLC22A7_9847;ABCB1B_7939;ABCB1A_7938 92.30923333333334 49.1516 20.7941 100.31659639762174 79.99217017711229 95.30696298583015 46.626016666666665 13.5995 8.25355 61.891081030515494 39.44030813803974 58.332491145538775 583.3561666666666 161.307 57.2115 822.8077706600633 486.6289293210005 776.6431999672176 0.5 34.97285 1.5 128.0668 49.1516;20.7941;206.982 13.5995;8.25355;118.025 161.307;57.2115;1531.55 0 3 0 3 89776;24646;170913 SLC22A7_9847;ABCB1B_7939;ABCB1A_7938 92.30923333333334 49.1516 100.31659639762174 46.626016666666665 13.5995 61.891081030515494 583.3561666666666 161.307 822.8077706600633 49.1516;20.7941;206.982 13.5995;8.25355;118.025 161.307;57.2115;1531.55 0 Hill,2(0.67);Poly 2,1(0.34) 2.8093431772023356 9.975937485694885 1.8874764442443848 6.191005229949951 2.4817677236811955 1.8974558115005493 -21.209681978000418 205.8281486446671 -23.410334628407227 116.66236796174057 -347.7384775818641 1514.4508109151973 DOWN 0.0 1.0 0.0 GO:0006950 3 response to stress 773 821 72 71 48 48 37 37 31 784 1695 0.99996 1.0559E-4 1.7656E-4 4.51 116669;688621;360243;25671;295703;25682;299112;363131;362282;304545;300795;338475;24314;313108;81687;291234;316273;293502;24426;25283;361921;312495;24296;245920;84032;24854;114494;29397;686019;24232;246142;25612;29657;29221;81639;24646;170913 vwf;tslp;top2a;smad1;serping1;ppard;pole2;pik3r4;pck1;oasl;pclaf;nrep;nqo1;mms22l;mmp9;mki67;mcm3;kif22;gstp1;gclc;ect2;cyp26b1;cyp1a1;cxcl10;col3a1;clu;ccna2;ccl11;casq1;c3;bmf;asns;arntl;arg1;alox15;abcb1b;abcb1a VWF_32396;TSLP_32811;TOP2A_10059;SMAD1_32578;SERPING1_32597;PPARD_9536;POLE2_9520;PIK3R4_9484;PCK1_9439;OASL_9389;NS5ATP9_9367;NREP_9364;NQO1_33055;MMS22L_33129;MMP9_32531;MKI67_9232;MCM3_9207;KIF22_8963;GSTP1_8762;GCLC_8699;ECT2_8523;CYP26B1_8418;CYP1A1_8415;CXCL10_8408;COL3A1_8354;CLU_32773;CCNA2_8221;CCL11_33230;CASQ1_32992;C3_8175;BMF_8152;ASNS_8091;ARNTL_8086;ARG1_33267;ALOX15_8036;ABCB1B_7939;ABCB1A_7938 246.22284054788105 119.401 2.71598E-7 310.437898588 204.43277030111318 284.50924329184943 151.7387970343675 39.9158 2.71598E-7 213.6229615413497 122.70149015550979 188.59617174249976 639.0843756830162 260.389 2.71599E-7 794.139697049516 555.6551499861924 777.3391274807209 19.6764;344.675;86.3883;21.9973;32.3997;94.1074;2.71598E-7;955.628;529.244;76.6126;292.216;61.543;25.6813;126.653;728.316;21.9311;197.273;17.3097;14.7631;131.7;10.0162;18.1872;12.8863;670.528;212.603;935.649;14.384;986.476;147.66;234.759;119.401;191.145;22.9134;760.927;766.819;20.7941;206.982 4.11644;244.2;26.6888;5.02186;13.7308;37.7692;2.71598E-7;735.228;356.883;28.4477;147.515;25.6719;7.73944;85.587;443.137;6.82654;116.413;3.12114;9.42992;39.9158;3.29405;10.0176;9.13136;374.802;119.81;808.484;4.89199;552.974;96.6023;129.148;81.8286;113.564;11.4115;413.607;421.048;8.25355;118.025 94.078;560.435;262.273;80.1461;99.4885;148.485;2.71599E-7;1288.97;1021.06;260.389;658.494;148.788;86.1211;240.486;2039.06;76.1794;496.915;90.6321;25.7196;397.209;37.7305;36.7271;19.3234;1955.3;1510.69;1071.05;58.2504;2230.86;285.773;694.216;220.085;510.267;50.1592;2639.93;2662.07;57.2115;1531.55 6 31 6 362282;24314;24426;312495;24296;29397 PCK1_9439;NQO1_33055;GSTP1_8762;CYP26B1_8418;CYP1A1_8415;CCL11_33230 264.53965 21.93425 408.58807149550876 157.69588666666667 9.723759999999999 238.4409028264289 569.9685333333333 61.424099999999996 903.3178515462243 529.244;25.6813;14.7631;18.1872;12.8863;986.476 356.883;7.73944;9.42992;10.0176;9.13136;552.974 1021.06;86.1211;25.7196;36.7271;19.3234;2230.86 31 116669;688621;360243;25671;295703;25682;299112;363131;304545;300795;338475;313108;81687;291234;316273;293502;25283;361921;245920;84032;24854;114494;686019;24232;246142;25612;29657;29221;81639;24646;170913 VWF_32396;TSLP_32811;TOP2A_10059;SMAD1_32578;SERPING1_32597;PPARD_9536;POLE2_9520;PIK3R4_9484;OASL_9389;NS5ATP9_9367;NREP_9364;MMS22L_33129;MMP9_32531;MKI67_9232;MCM3_9207;KIF22_8963;GCLC_8699;ECT2_8523;CXCL10_8408;COL3A1_8354;CLU_32773;CCNA2_8221;CASQ1_32992;C3_8175;BMF_8152;ASNS_8091;ARNTL_8086;ARG1_33267;ALOX15_8036;ABCB1B_7939;ABCB1A_7938 242.6776516216644 126.653 296.2125974407051 150.5858119442451 81.8286 212.78527958948 652.4616354926321 262.273 787.1797278344 19.6764;344.675;86.3883;21.9973;32.3997;94.1074;2.71598E-7;955.628;76.6126;292.216;61.543;126.653;728.316;21.9311;197.273;17.3097;131.7;10.0162;670.528;212.603;935.649;14.384;147.66;234.759;119.401;191.145;22.9134;760.927;766.819;20.7941;206.982 4.11644;244.2;26.6888;5.02186;13.7308;37.7692;2.71598E-7;735.228;28.4477;147.515;25.6719;85.587;443.137;6.82654;116.413;3.12114;39.9158;3.29405;374.802;119.81;808.484;4.89199;96.6023;129.148;81.8286;113.564;11.4115;413.607;421.048;8.25355;118.025 94.078;560.435;262.273;80.1461;99.4885;148.485;2.71599E-7;1288.97;260.389;658.494;148.788;240.486;2039.06;76.1794;496.915;90.6321;397.209;37.7305;1955.3;1510.69;1071.05;58.2504;285.773;694.216;220.085;510.267;50.1592;2639.93;2662.07;57.2115;1531.55 0 Exp 2,5(0.14);Exp 4,12(0.33);Exp 5,1(0.03);Hill,6(0.17);Linear,2(0.06);Poly 2,10(0.28);Power,1(0.03) 2.0141995151639236 87.48281371593475 1.5018656253814697 15.48720932006836 2.3691047107600505 1.805381178855896 146.19291529570296 346.252765800059 82.9047758909319 220.57281817780313 383.1950822141256 894.9736691519064 DOWN 0.16216216216216217 0.8378378378378378 0.0 GO:0009635 4 response to herbicide 15 16 2 2 2 2 2 2 66 14 2465 0.99205 0.066251 0.066251 12.5 24296;29221 cyp1a1;arg1 CYP1A1_8415;ARG1_33267 386.90665 386.90665 12.8863 528.9446515735319 470.2429782729162 515.6477064898306 211.36918000000003 211.36918000000003 9.13136 286.00746786876874 256.4302504918033 278.81763130937446 1329.6267 1329.6267 19.3234 1853.0486976822222 1621.5783703994457 1806.4655879046597 0.0 12.8863 0.5 386.90665 12.8863;760.927 9.13136;413.607 19.3234;2639.93 1 1 1 24296 CYP1A1_8415 12.8863 12.8863 9.13136 9.13136 19.3234 19.3234 12.8863 9.13136 19.3234 1 29221 ARG1_33267 760.927 760.927 413.607 413.607 2639.93 2639.93 760.927 413.607 2639.93 0 Exp 2,1(0.5);Exp 4,1(0.5) 4.841675924682754 17.000834226608276 1.513624906539917 15.48720932006836 9.880816296288607 8.500417113304138 -346.17323599999986 1119.986536 -185.01694719999998 607.7553072 -1238.5677679999994 3897.821167999999 CONFLICT 0.5 0.5 0.0 GO:0051016 10 barbed-end actin filament capping 2 2 1 1 1 1 1 1 67 1 2478 0.9993 0.052694 0.052694 50.0 684352 twf2 TWF2_10109 138.399 138.399 138.399 138.399 90.7363 90.7363 90.7363 90.7363 299.165 299.165 299.165 299.165 0.0 138.399 0.0 138.399 138.399 90.7363 299.165 0 1 0 1 684352 TWF2_10109 138.399 138.399 90.7363 90.7363 299.165 299.165 138.399 90.7363 299.165 0 Poly 2,1(1) 1.7946586608886719 1.7946586608886719 1.7946586608886719 1.7946586608886719 0.0 1.7946586608886719 138.399 138.399 90.7363 90.7363 299.165 299.165 DOWN 0.0 1.0 0.0 GO:0009893 5 positive regulation of metabolic process 777 837 48 47 34 30 24 24 44 813 1666 0.71664 0.37657 0.69514 2.87 688621;360243;24832;25671;25682;363131;25154;362282;259241;316351;81687;24426;25283;24367;361921;312495;24854;306575;113902;114494;29397;24232;29657;81639 tslp;top2a;thy1;smad1;ppard;pik3r4;pgr;pck1;nr1d2;npas2;mmp9;gstp1;gclc;fgg;ect2;cyp26b1;clu;ckap2;ces1d;ccna2;ccl11;c3;arntl;alox15 TSLP_32811;TOP2A_10059;THY1_33010;SMAD1_32578;PPARD_9536;PIK3R4_9484;PGR_32824;PCK1_9439;NR1D2_9358;NPAS2_9350;MMP9_32531;GSTP1_8762;GCLC_8699;FGG_8639;ECT2_8523;CYP26B1_8418;CLU_32773;CKAP2_8324;CES1D_32914;CCNA2_8221;CCL11_33230;C3_8175;ARNTL_8086;ALOX15_8036 263.1529041666669 64.42475 5.72311E-12 348.4442455442419 242.63036038192118 334.40596320058813 168.04303833333356 23.665599999999998 5.72311E-12 248.80257152081808 148.36610510535607 229.87783939841543 607.0019291666669 131.2615 5.72313E-12 800.4374215070272 587.0647443205627 821.6476679603016 344.675;86.3883;5.72311E-12;21.9973;94.1074;955.628;283.618;529.244;29.1728;21.0878;728.316;14.7631;131.7;42.4612;10.0162;18.1872;935.649;32.2386;11.0684;14.384;986.476;234.759;22.9134;766.819 244.2;26.6888;5.72311E-12;5.02186;37.7692;735.228;138.711;356.883;3.35457;11.3305;443.137;9.42992;39.9158;20.6424;3.29405;10.0176;808.484;15.2683;4.18343;4.89199;552.974;129.148;11.4115;421.048 560.435;262.273;5.72313E-12;80.1461;148.485;1288.97;1554.21;1021.06;114.038;43.5624;2039.06;25.7196;397.209;98.0534;37.7305;36.7271;1071.05;76.7052;17.0564;58.2504;2230.86;694.216;50.1592;2662.07 5 19 5 362282;259241;24426;312495;29397 PCK1_9439;NR1D2_9358;GSTP1_8762;CYP26B1_8418;CCL11_33230 315.56862 29.1728 434.9471565873744 186.53181800000002 10.0176 254.64468066991193 685.68094 114.038 959.6253369083885 529.244;29.1728;14.7631;18.1872;986.476 356.883;3.35457;9.42992;10.0176;552.974 1021.06;114.038;25.7196;36.7271;2230.86 19 688621;360243;24832;25671;25682;363131;25154;316351;81687;25283;24367;361921;24854;306575;113902;114494;24232;29657;81639 TSLP_32811;TOP2A_10059;THY1_33010;SMAD1_32578;PPARD_9536;PIK3R4_9484;PGR_32824;NPAS2_9350;MMP9_32531;GCLC_8699;FGG_8639;ECT2_8523;CLU_32773;CKAP2_8324;CES1D_32914;CCNA2_8221;C3_8175;ARNTL_8086;ALOX15_8036 249.35929473684237 86.3883 334.8664625912085 163.1775700000003 26.6888 254.10277223026014 586.2969263157898 148.485 782.2148462975739 344.675;86.3883;5.72311E-12;21.9973;94.1074;955.628;283.618;21.0878;728.316;131.7;42.4612;10.0162;935.649;32.2386;11.0684;14.384;234.759;22.9134;766.819 244.2;26.6888;5.72311E-12;5.02186;37.7692;735.228;138.711;11.3305;443.137;39.9158;20.6424;3.29405;808.484;15.2683;4.18343;4.89199;129.148;11.4115;421.048 560.435;262.273;5.72313E-12;80.1461;148.485;1288.97;1554.21;43.5624;2039.06;397.209;98.0534;37.7305;1071.05;76.7052;17.0564;58.2504;694.216;50.1592;2662.07 0 Exp 2,2(0.09);Exp 4,11(0.46);Exp 5,2(0.09);Hill,2(0.09);Linear,2(0.09);Poly 2,4(0.17);Power,1(0.05) 1.9521277348462012 48.50046241283417 1.5018656253814697 3.5281898975372314 0.5967176209064373 1.9010515809059143 123.7461719525678 402.55963638076605 68.5012783366743 267.5847983299928 286.76026439219146 927.2435939411425 DOWN 0.20833333333333334 0.7916666666666666 0.0 GO:0097009 5 energy homeostasis 9 10 1 1 1 1 1 1 67 9 2470 0.97247 0.23746 0.23746 10.0 259241 nr1d2 NR1D2_9358 29.1728 29.1728 29.1728 29.172800000000002 3.35457 3.35457 3.35457 3.35457 114.038 114.038 114.038 114.038 0.0 29.1728 0.0 29.1728 29.1728 3.35457 114.038 1 0 1 259241 NR1D2_9358 29.1728 29.1728 3.35457 3.35457 114.038 114.038 29.1728 3.35457 114.038 0 0 Exp 4,1(1) 2.1823768615722656 2.1823768615722656 2.1823768615722656 2.1823768615722656 0.0 2.1823768615722656 29.1728 29.1728 3.35457 3.35457 114.038 114.038 UP 1.0 0.0 0.0 GO:0090066 4 regulation of anatomical structure size 103 112 11 11 9 9 7 7 61 105 2374 0.99114 0.02779 0.02779 6.25 684352;25682;288583;25283;24367;29397;81639 twf2;ppard;plod3;gclc;fgg;ccl11;alox15 TWF2_10109;PPARD_9536;PLOD3_9507;GCLC_8699;FGG_8639;CCL11_33230;ALOX15_8036 434.65594285714286 138.399 42.4612 421.27940803224186 362.8580093450831 404.0645119464071 255.5375285714286 90.7363 20.6424 267.431093967516 199.10395797054778 244.35765961471097 991.6946285714286 397.209 98.0534 1055.2537263553093 927.8569010158974 1079.596012397968 4.5 824.7239999999999 138.399;94.1074;882.629;131.7;42.4612;986.476;766.819 90.7363;37.7692;625.677;39.9158;20.6424;552.974;421.048 299.165;148.485;1106.02;397.209;98.0534;2230.86;2662.07 1 6 1 29397 CCL11_33230 986.476 986.476 552.974 552.974 2230.86 2230.86 986.476 552.974 2230.86 6 684352;25682;288583;25283;24367;81639 TWF2_10109;PPARD_9536;PLOD3_9507;GCLC_8699;FGG_8639;ALOX15_8036 342.68593333333337 135.0495 376.72317858501174 205.96478333333334 65.32605 255.30497181427876 785.1670666666668 348.187 988.9297185558672 138.399;94.1074;882.629;131.7;42.4612;766.819 90.7363;37.7692;625.677;39.9158;20.6424;421.048 299.165;148.485;1106.02;397.209;98.0534;2662.07 0 Exp 2,1(0.15);Exp 4,1(0.15);Exp 5,1(0.15);Hill,1(0.15);Poly 2,2(0.29);Power,1(0.15) 1.927624471377993 13.725577712059021 1.5021449327468872 2.8176381587982178 0.41495633151924183 1.9388991594314575 122.56778994191359 746.7440957723721 57.421801675910444 453.6532554669467 209.95172816852937 1773.4375289743277 DOWN 0.14285714285714285 0.8571428571428571 0.0 GO:0051897 8 positive regulation of protein kinase B signaling 32 35 2 2 1 2 1 1 67 34 2445 0.76046 0.61465 0.61465 2.86 29243 f10 F10_8585 104.19 104.19 104.19 104.19 38.4229 38.4229 38.4229 38.4229 163.044 163.044 163.044 163.044 104.19 38.4229 163.044 0 1 0 1 29243 F10_8585 104.19 104.19 38.4229 38.4229 163.044 163.044 104.19 38.4229 163.044 0 Exp 5,1(1) 1.5225032567977905 1.5225032567977905 1.5225032567977905 1.5225032567977905 0.0 1.5225032567977905 104.19 104.19 38.4229 38.4229 163.044 163.044 DOWN 0.0 1.0 0.0 GO:0031326 6 regulation of cellular biosynthetic process 611 656 35 32 22 19 14 14 54 642 1837 0.20019 0.87196 0.39901 2.13 360243;25671;25682;25154;362282;259241;316351;25283;24854;306575;113902;114494;24232;29657 top2a;smad1;ppard;pgr;pck1;nr1d2;npas2;gclc;clu;ckap2;ces1d;ccna2;c3;arntl TOP2A_10059;SMAD1_32578;PPARD_9536;PGR_32824;PCK1_9439;NR1D2_9358;NPAS2_9350;GCLC_8699;CLU_32773;CKAP2_8324;CES1D_32914;CCNA2_8221;C3_8175;ARNTL_8086 174.88057142857141 59.31345 11.0684 263.15564875170924 145.37251895154967 242.0931011442072 113.79013928571429 20.97855 3.35457 221.87293040600235 90.16072051586265 210.00962170116077 399.1729071428571 131.2615 17.0564 491.3473929724302 324.91848611125624 404.614331973042 86.3883;21.9973;94.1074;283.618;529.244;29.1728;21.0878;131.7;935.649;32.2386;11.0684;14.384;234.759;22.9134 26.6888;5.02186;37.7692;138.711;356.883;3.35457;11.3305;39.9158;808.484;15.2683;4.18343;4.89199;129.148;11.4115 262.273;80.1461;148.485;1554.21;1021.06;114.038;43.5624;397.209;1071.05;76.7052;17.0564;58.2504;694.216;50.1592 2 12 2 362282;259241 PCK1_9439;NR1D2_9358 279.20840000000004 279.20840000000004 353.6037365960942 180.118785 180.118785 249.98235019523364 567.549 567.549 641.3614068853847 529.244;29.1728 356.883;3.35457 1021.06;114.038 12 360243;25671;25682;25154;316351;25283;24854;306575;113902;114494;24232;29657 TOP2A_10059;SMAD1_32578;PPARD_9536;PGR_32824;NPAS2_9350;GCLC_8699;CLU_32773;CKAP2_8324;CES1D_32914;CCNA2_8221;C3_8175;ARNTL_8086 157.4926 59.31345 261.0867756026964 102.735365 20.97855 227.0767018797625 371.11022499999996 114.31555 491.84196893534477 86.3883;21.9973;94.1074;283.618;21.0878;131.7;935.649;32.2386;11.0684;14.384;234.759;22.9134 26.6888;5.02186;37.7692;138.711;11.3305;39.9158;808.484;15.2683;4.18343;4.89199;129.148;11.4115 262.273;80.1461;148.485;1554.21;43.5624;397.209;1071.05;76.7052;17.0564;58.2504;694.216;50.1592 0 Exp 4,7(0.5);Exp 5,2(0.15);Hill,1(0.08);Linear,1(0.08);Poly 2,3(0.22) 1.9247849391757368 27.84256160259247 1.5405861139297485 3.442979335784912 0.5842335094539337 1.8160573244094849 37.03121264533439 312.72993021180844 -2.4340091713176406 230.0142877427462 141.7894028086194 656.5564114770948 DOWN 0.14285714285714285 0.8571428571428571 0.0 GO:0007610 2 behavior 142 151 10 10 6 6 4 4 64 147 2332 0.62266 0.5814 1.0 2.65 25154;259241;316351;29397 pgr;nr1d2;npas2;ccl11 PGR_32824;NR1D2_9358;NPAS2_9350;CCL11_33230 330.08865000000003 156.3954 21.0878 454.2524073072847 337.0719851961598 485.9066977951005 176.5925175 75.02075 3.35457 258.47046937653806 182.55129353443166 275.9084662329851 985.6676 834.124 43.5624 1083.3658878819474 902.6395653431315 1129.9920825417773 283.618;29.1728;21.0878;986.476 138.711;3.35457;11.3305;552.974 1554.21;114.038;43.5624;2230.86 2 2 2 259241;29397 NR1D2_9358;CCL11_33230 507.8244 507.8244 676.9155843715816 278.164285 278.164285 388.639626024885 1172.449 1172.449 1496.8191907648697 29.1728;986.476 3.35457;552.974 114.038;2230.86 2 25154;316351 PGR_32824;NPAS2_9350 152.3529 152.3529 185.63688468626057 75.02075 75.02075 90.07161534093304 798.8862 798.8862 1068.189161943183 283.618;21.0878 138.711;11.3305 1554.21;43.5624 0 Exp 4,2(0.5);Poly 2,1(0.25);Power,1(0.25) 2.1291013556959735 8.788909196853638 1.5405861139297485 3.0844674110412598 0.649394745951723 2.0819278359413147 -115.07870916113899 775.256009161139 -76.70854248900727 429.89357748900727 -76.0309701243084 2047.3661701243084 CONFLICT 0.5 0.5 0.0 GO:0019538 4 protein metabolic process 588 639 41 41 26 27 19 19 49 620 1859 0.75904 0.33487 0.57224 2.97 315852;24832;25671;291463;25682;288583;363131;362282;81687;362376;156275;81919;24367;29243;84032;297594;114494;29397;29657 ttk;thy1;smad1;ppic;ppard;plod3;pik3r4;pck1;mmp9;herc6;ggt7;fut1;fgg;f10;col3a1;cdca3;ccna2;ccl11;arntl TTK_32727;THY1_33010;SMAD1_32578;PPIC_9541;PPARD_9536;PLOD3_9507;PIK3R4_9484;PCK1_9439;MMP9_32531;HERC6_8794;GGT7_33026;FUT1_8668;FGG_8639;F10_8585;COL3A1_8354;CDCA3_8260;CCNA2_8221;CCL11_33230;ARNTL_8086 337.25215789473714 109.609 5.72311E-12 364.8867377377581 293.67012339793064 343.42361763853796 207.05992368421084 38.4229 5.72311E-12 249.84813674350895 167.70785344709964 222.92644014446702 784.9822684210529 346.073 5.72313E-12 792.9068609389053 749.8923241705867 821.0625920854397 737.351;5.72311E-12;21.9973;628.678;94.1074;882.629;955.628;529.244;728.316;39.6865;109.609;240.861;42.4612;104.19;212.603;56.6562;14.384;986.476;22.9134 446.625;5.72311E-12;5.02186;389.239;37.7692;625.677;735.228;356.883;443.137;15.7729;29.3336;78.9726;20.6424;38.4229;119.81;22.3266;4.89199;552.974;11.4115 2108.09;5.72313E-12;80.1461;1509.86;148.485;1106.02;1288.97;1021.06;2039.06;157.407;346.073;847.87;98.0534;163.044;1510.69;150.565;58.2504;2230.86;50.1592 2 17 2 362282;29397 PCK1_9439;CCL11_33230 757.86 757.86 323.3118477754875 454.9285 454.9285 138.65727582965147 1625.96 1625.96 855.4577838794855 529.244;986.476 356.883;552.974 1021.06;2230.86 17 315852;24832;25671;291463;25682;288583;363131;81687;362376;156275;81919;24367;29243;84032;297594;114494;29657 TTK_32727;THY1_33010;SMAD1_32578;PPIC_9541;PPARD_9536;PLOD3_9507;PIK3R4_9484;MMP9_32531;HERC6_8794;GGT7_33026;FUT1_8668;FGG_8639;F10_8585;COL3A1_8354;CDCA3_8260;CCNA2_8221;ARNTL_8086 287.7688823529415 104.19 344.29124595859076 177.89891470588267 37.7692 245.84979508161382 686.0437117647061 163.044 750.163226668176 737.351;5.72311E-12;21.9973;628.678;94.1074;882.629;955.628;728.316;39.6865;109.609;240.861;42.4612;104.19;212.603;56.6562;14.384;22.9134 446.625;5.72311E-12;5.02186;389.239;37.7692;625.677;735.228;443.137;15.7729;29.3336;78.9726;20.6424;38.4229;119.81;22.3266;4.89199;11.4115 2108.09;5.72313E-12;80.1461;1509.86;148.485;1106.02;1288.97;2039.06;157.407;346.073;847.87;98.0534;163.044;1510.69;150.565;58.2504;50.1592 0 Exp 2,2(0.11);Exp 4,7(0.37);Exp 5,2(0.11);Hill,1(0.06);Linear,3(0.16);Poly 2,3(0.16);Power,1(0.06) 1.918063422744176 37.42458534240723 1.5018656253814697 3.442979335784912 0.5113943165052067 1.863204002380371 173.1790708079609 501.3252449815134 94.71450013568989 319.4053472327318 428.44786201018024 1141.516674831926 DOWN 0.10526315789473684 0.8947368421052632 0.0 GO:0006775 5 fat-soluble vitamin metabolic process 10 13 2 2 2 2 2 2 66 11 2468 0.9957 0.04532 0.04532 15.38 25682;312495 ppard;cyp26b1 PPARD_9536;CYP26B1_8418 56.1473 56.1473 18.1872 53.68368824903892 47.07433855050115 52.12773853805491 23.8934 23.8934 10.0176 19.623344548776593 20.576901927525054 19.05458822306429 92.60605000000001 92.60605000000001 36.7271 79.02476894116806 79.25024853508096 76.73434199016981 0.0 18.1872 0.5 56.1473 94.1074;18.1872 37.7692;10.0176 148.485;36.7271 1 1 1 312495 CYP26B1_8418 18.1872 18.1872 10.0176 10.0176 36.7271 36.7271 18.1872 10.0176 36.7271 1 25682 PPARD_9536 94.1074 94.1074 37.7692 37.7692 148.485 148.485 94.1074 37.7692 148.485 0 Exp 4,1(0.5);Exp 5,1(0.5) 2.013193623464536 4.029234051704407 1.9388991594314575 2.090334892272949 0.10708123360617314 2.0146170258522034 -18.25449599999999 130.549096 -3.303167999999996 51.089968 -16.916691999999998 202.12879200000003 CONFLICT 0.5 0.5 0.0 GO:0010604 6 positive regulation of macromolecule metabolic process 704 754 44 43 31 26 21 21 47 733 1746 0.64931 0.45356 0.78922 2.79 688621;360243;24832;25671;25682;25154;362282;259241;316351;81687;25283;24367;361921;312495;24854;306575;114494;29397;24232;29657;81639 tslp;top2a;thy1;smad1;ppard;pgr;pck1;nr1d2;npas2;mmp9;gclc;fgg;ect2;cyp26b1;clu;ckap2;ccna2;ccl11;c3;arntl;alox15 TSLP_32811;TOP2A_10059;THY1_33010;SMAD1_32578;PPARD_9536;PGR_32824;PCK1_9439;NR1D2_9358;NPAS2_9350;MMP9_32531;GCLC_8699;FGG_8639;ECT2_8523;CYP26B1_8418;CLU_32773;CKAP2_8324;CCNA2_8221;CCL11_33230;C3_8175;ARNTL_8086;ALOX15_8036 254.01000952380977 86.3883 5.72311E-12 330.60450151509247 240.7531737311643 328.1637089954544 156.39007476190505 26.6888 5.72311E-12 228.82351874776967 144.5370174122636 221.72150745617787 630.3000142857146 148.485 5.72313E-12 823.8233236813284 601.3835854005193 835.7517694859181 344.675;86.3883;5.72311E-12;21.9973;94.1074;283.618;529.244;29.1728;21.0878;728.316;131.7;42.4612;10.0162;18.1872;935.649;32.2386;14.384;986.476;234.759;22.9134;766.819 244.2;26.6888;5.72311E-12;5.02186;37.7692;138.711;356.883;3.35457;11.3305;443.137;39.9158;20.6424;3.29405;10.0176;808.484;15.2683;4.89199;552.974;129.148;11.4115;421.048 560.435;262.273;5.72313E-12;80.1461;148.485;1554.21;1021.06;114.038;43.5624;2039.06;397.209;98.0534;37.7305;36.7271;1071.05;76.7052;58.2504;2230.86;694.216;50.1592;2662.07 4 17 4 362282;259241;312495;29397 PCK1_9439;NR1D2_9358;CYP26B1_8418;CCL11_33230 390.77 279.20840000000004 463.18144933192934 230.80729250000002 183.4503 270.9054575123473 850.671275 567.549 1022.9185265826254 529.244;29.1728;18.1872;986.476 356.883;3.35457;10.0176;552.974 1021.06;114.038;36.7271;2230.86 17 688621;360243;24832;25671;25682;25154;316351;81687;25283;24367;361921;24854;306575;114494;24232;29657;81639 TSLP_32811;TOP2A_10059;THY1_33010;SMAD1_32578;PPARD_9536;PGR_32824;NPAS2_9350;MMP9_32531;GCLC_8699;FGG_8639;ECT2_8523;CLU_32773;CKAP2_8324;CCNA2_8221;C3_8175;ARNTL_8086;ALOX15_8036 221.83118823529443 86.3883 301.0356376611803 138.88014117647094 26.6888 223.56080025464436 578.4479529411768 148.485 798.2265362209753 344.675;86.3883;5.72311E-12;21.9973;94.1074;283.618;21.0878;728.316;131.7;42.4612;10.0162;935.649;32.2386;14.384;234.759;22.9134;766.819 244.2;26.6888;5.72311E-12;5.02186;37.7692;138.711;11.3305;443.137;39.9158;20.6424;3.29405;808.484;15.2683;4.89199;129.148;11.4115;421.048 560.435;262.273;5.72313E-12;80.1461;148.485;1554.21;43.5624;2039.06;397.209;98.0534;37.7305;1071.05;76.7052;58.2504;694.216;50.1592;2662.07 0 Exp 2,2(0.1);Exp 4,10(0.48);Exp 5,1(0.05);Hill,2(0.1);Linear,2(0.1);Poly 2,3(0.15);Power,1(0.05) 1.9384688426822096 41.843438148498535 1.5021449327468872 3.442979335784912 0.5232718377864578 1.9388991594314575 112.60812855044475 395.41189049717485 58.52063918677692 254.2595103370332 277.9449585486672 982.655070022762 DOWN 0.19047619047619047 0.8095238095238095 0.0 GO:0030335 7 positive regulation of cell migration 186 194 17 17 10 11 7 7 61 187 2292 0.85831 0.2575 0.35546 3.61 24832;25154;81687;81919;309186;245920;29397 thy1;pgr;mmp9;fut1;fermt3;cxcl10;ccl11 THY1_33010;PGR_32824;MMP9_32531;FUT1_8668;FERMT3_32542;CXCL10_8408;CCL11_33230 492.7017142857152 539.113 5.72311E-12 337.3914779622782 499.30490454606115 343.52918510616433 274.6920857142865 334.248 5.72311E-12 204.79100303573946 274.563206772431 215.71739867621523 1402.165714285715 1554.21 5.72313E-12 789.5866979599107 1387.9595430609256 783.323697818969 5.72311E-12;283.618;728.316;240.861;539.113;670.528;986.476 5.72311E-12;138.711;443.137;78.9726;334.248;374.802;552.974 5.72313E-12;1554.21;2039.06;847.87;1187.86;1955.3;2230.86 1 6 1 29397 CCL11_33230 986.476 986.476 552.974 552.974 2230.86 2230.86 986.476 552.974 2230.86 6 24832;25154;81687;81919;309186;245920 THY1_33010;PGR_32824;MMP9_32531;FUT1_8668;FERMT3_32542;CXCL10_8408 410.40600000000103 411.3655 282.3294188135538 228.31176666666764 236.4795 179.6042882327873 1264.0500000000009 1371.0349999999999 766.7454596148563 5.72311E-12;283.618;728.316;240.861;539.113;670.528 5.72311E-12;138.711;443.137;78.9726;334.248;374.802 5.72313E-12;1554.21;2039.06;847.87;1187.86;1955.3 0 Exp 2,3(0.43);Hill,1(0.15);Linear,1(0.15);Poly 2,1(0.15);Power,1(0.15) 1.927606547770689 13.697802901268005 1.5405861139297485 2.737008571624756 0.38577099202688975 1.863204002380371 242.7586096407142 742.644818930716 122.98078757699528 426.40338385157776 817.2317027142684 1987.0997258571615 DOWN 0.14285714285714285 0.8571428571428571 0.0 GO:0098609 4 cell-cell adhesion 84 86 6 5 5 4 3 3 65 83 2396 0.80472 0.4052 0.49891 3.49 24832;24367;309186 thy1;fgg;fermt3 THY1_33010;FGG_8639;FERMT3_32542 193.8580666666686 42.4612 5.72311E-12 299.7523396399304 151.58937019730158 268.3894449173426 118.2968000000019 20.6424 5.72311E-12 187.30381137478042 91.09508233199965 168.18967074164087 428.63780000000185 98.0534 5.72313E-12 659.331008706945 336.2920128319255 589.969049442082 5.72311E-12;42.4612;539.113 5.72311E-12;20.6424;334.248 5.72313E-12;98.0534;1187.86 0 3 0 3 24832;24367;309186 THY1_33010;FGG_8639;FERMT3_32542 193.8580666666686 42.4612 299.7523396399304 118.2968000000019 20.6424 187.30381137478042 428.63780000000185 98.0534 659.331008706945 5.72311E-12;42.4612;539.113 5.72311E-12;20.6424;334.248 5.72313E-12;98.0534;1187.86 0 Exp 2,1(0.34);Exp 4,1(0.34);Hill,1(0.34) 2.062147787124556 6.351216197013855 1.6703740358352661 2.8176381587982178 0.6143211595971583 1.863204002380371 -145.3436375367461 533.0597708700833 -93.65741559824394 330.2510155982477 -317.46547330956145 1174.741073309565 DOWN 0.0 1.0 0.0 GO:0043269 6 regulation of ion transport 174 184 13 12 9 9 7 7 61 177 2302 0.88651 0.21678 0.33614 3.8 24832;81687;245920;113902;686019;29221;170913 thy1;mmp9;cxcl10;ces1d;casq1;arg1;abcb1a THY1_33010;MMP9_32531;CXCL10_8408;CES1D_32914;CASQ1_32992;ARG1_33267;ABCB1A_7938 360.78305714285796 206.982 5.72311E-12 344.6443884939309 368.5158704485649 325.6016903353716 207.19381857142938 118.025 5.72311E-12 196.08337823460977 215.40223032107198 186.17863597061853 1209.8099142857152 1531.55 5.72313E-12 1090.2840997022972 1258.7333575238326 1045.5795827140457 5.72311E-12;728.316;670.528;11.0684;147.66;760.927;206.982 5.72311E-12;443.137;374.802;4.18343;96.6023;413.607;118.025 5.72313E-12;2039.06;1955.3;17.0564;285.773;2639.93;1531.55 0 7 0 7 24832;81687;245920;113902;686019;29221;170913 THY1_33010;MMP9_32531;CXCL10_8408;CES1D_32914;CASQ1_32992;ARG1_33267;ABCB1A_7938 360.78305714285796 206.982 344.6443884939309 207.19381857142938 118.025 196.08337823460977 1209.8099142857152 1531.55 1090.2840997022972 5.72311E-12;728.316;670.528;11.0684;147.66;760.927;206.982 5.72311E-12;443.137;374.802;4.18343;96.6023;413.607;118.025 5.72313E-12;2039.06;1955.3;17.0564;285.773;2639.93;1531.55 0 Exp 2,2(0.29);Exp 5,1(0.15);Hill,1(0.15);Linear,1(0.15);Poly 2,2(0.29) 1.8586915605513865 13.123492121696472 1.513624906539917 2.327066659927368 0.267182069174801 1.863204002380371 105.46692118437397 616.099193101342 61.93321915961545 352.4544179832434 402.11615014405095 2017.5036784273793 DOWN 0.0 1.0 0.0 GO:0006468 7 protein phosphorylation 190 202 11 11 9 8 6 6 62 196 2283 0.70834 0.45619 0.8184 2.97 315852;24832;25671;363131;114494;29397 ttk;thy1;smad1;pik3r4;ccna2;ccl11 TTK_32727;THY1_33010;SMAD1_32578;PIK3R4_9484;CCNA2_8221;CCL11_33230 452.6393833333343 379.67415 5.72311E-12 490.1923260839572 457.19175260834186 489.5347233549915 290.7901416666676 225.82343 5.72311E-12 328.17984672611937 278.7918253093065 306.5916574384831 961.0527500000011 684.55805 5.72313E-12 1053.5943835603894 1049.3832955655814 1117.287066067823 737.351;5.72311E-12;21.9973;955.628;14.384;986.476 446.625;5.72311E-12;5.02186;735.228;4.89199;552.974 2108.09;5.72313E-12;80.1461;1288.97;58.2504;2230.86 1 5 1 29397 CCL11_33230 986.476 986.476 552.974 552.974 2230.86 2230.86 986.476 552.974 2230.86 5 315852;24832;25671;363131;114494 TTK_32727;THY1_33010;SMAD1_32578;PIK3R4_9484;CCNA2_8221 345.87206000000117 21.9973 463.53660664640825 238.35337000000112 5.02186 337.64686001103 707.0913000000012 80.1461 950.7119809341461 737.351;5.72311E-12;21.9973;955.628;14.384 446.625;5.72311E-12;5.02186;735.228;4.89199 2108.09;5.72313E-12;80.1461;1288.97;58.2504 0 Exp 4,2(0.34);Hill,1(0.17);Linear,1(0.17);Poly 2,1(0.17);Power,1(0.17) 1.6873524923656038 10.177713632583618 1.5018656253814697 1.9814788103103638 0.19292895274498872 1.6600053310394287 60.40383225366543 844.8749344130032 28.191573341031187 553.388709992304 118.00166237552207 1804.1038376244799 DOWN 0.16666666666666666 0.8333333333333334 0.0 GO:0000902 4 cell morphogenesis 62 65 7 7 5 4 4 4 64 61 2418 0.97198 0.093345 0.093345 6.15 288583;309186;361921;24854 plod3;fermt3;ect2;clu PLOD3_9507;FERMT3_32542;ECT2_8523;CLU_32773 591.8518 710.8710000000001 10.0162 425.8567604333957 457.42676843203765 467.8767839481882 442.9257625 479.9625 3.29405 352.19205864110427 349.43457966344903 387.46996877925017 850.665125 1088.5349999999999 37.7305 544.1625656502497 666.5958481607095 618.7168390398456 2.5 909.139 882.629;539.113;10.0162;935.649 625.677;334.248;3.29405;808.484 1106.02;1187.86;37.7305;1071.05 0 4 0 4 288583;309186;361921;24854 PLOD3_9507;FERMT3_32542;ECT2_8523;CLU_32773 591.8518 710.8710000000001 425.8567604333957 442.9257625 479.9625 352.19205864110427 850.665125 1088.5349999999999 544.1625656502497 882.629;539.113;10.0162;935.649 625.677;334.248;3.29405;808.484 1106.02;1187.86;37.7305;1071.05 0 Exp 2,1(0.25);Exp 4,1(0.25);Poly 2,2(0.5) 1.6432164262195408 6.577137351036072 1.5548590421676636 1.7160688638687134 0.06807338789987588 1.6531047224998474 174.51217477527211 1009.1914252247279 97.77754503171798 788.0739799682821 317.38581066275503 1383.944439337245 DOWN 0.0 1.0 0.0 GO:0007017 3 microtubule-based process 97 110 7 7 5 4 3 3 65 107 2372 0.66209 0.57007 1.0 2.73 295661;300795;293502 spc25;pclaf;kif22 SPC25_9925;NS5ATP9_9367;KIF22_8963 115.13866666666667 35.8903 17.3097 153.63461901350013 53.19893191929893 97.2411374809981 54.07017999999999 11.5744 3.12114 81.03588828279231 21.348164637904468 51.248154843276424 291.04403333333335 124.006 90.6321 318.6582225563987 162.37589353813559 201.52741932534087 35.8903;292.216;17.3097 11.5744;147.515;3.12114 124.006;658.494;90.6321 0 3 0 3 295661;300795;293502 SPC25_9925;NS5ATP9_9367;KIF22_8963 115.13866666666667 35.8903 153.63461901350013 54.07017999999999 11.5744 81.03588828279231 291.04403333333335 124.006 318.6582225563987 35.8903;292.216;17.3097 11.5744;147.515;3.12114 124.006;658.494;90.6321 0 Exp 2,1(0.34);Exp 4,1(0.34);Hill,1(0.34) 1.7028326214834066 5.119402170181274 1.5933629274368286 1.8598893880844116 0.13776144708118893 1.6661498546600342 -58.715271076141505 288.99260440947484 -37.63056015161756 145.77092015161753 -69.55169138861868 651.6397580552854 DOWN 0.0 1.0 0.0 GO:0048147 7 negative regulation of fibroblast proliferation 11 11 3 3 3 3 3 3 65 8 2471 0.99987 0.0025766 0.0025766 27.27 24832;81687;24426 thy1;mmp9;gstp1 THY1_33010;MMP9_32531;GSTP1_8762 247.69303333333525 14.7631 5.72311E-12 416.2971466945239 372.4342190949491 441.6251014013285 150.8556400000019 9.42992 5.72311E-12 253.16699212256705 226.7111576507807 268.57262351079754 688.2598666666686 25.7196 5.72313E-12 1169.8979120487604 1038.9649505910713 1240.9710445424994 0.0 5.72311E-12 0.5 7.3815500000028615 5.72311E-12;728.316;14.7631 5.72311E-12;443.137;9.42992 5.72313E-12;2039.06;25.7196 1 2 1 24426 GSTP1_8762 14.7631 14.7631 9.42992 9.42992 25.7196 25.7196 14.7631 9.42992 25.7196 2 24832;81687 THY1_33010;MMP9_32531 364.15800000000286 364.15800000000286 514.9971824466576 221.56850000000287 221.56850000000287 313.34517769465907 1019.5300000000028 1019.5300000000028 1441.8331532462375 5.72311E-12;728.316 5.72311E-12;443.137 5.72313E-12;2039.06 0 Exp 4,1(0.34);Hill,1(0.34);Linear,1(0.34) 2.3802201710564668 7.442740440368652 1.863204002380371 3.5281898975372314 0.9118334960463407 2.05134654045105 -223.39153529229952 718.7776019589701 -135.62978086170634 437.34106086171016 -635.6042472469683 2012.1239805803054 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0080134 5 regulation of response to stress 340 358 26 26 17 20 16 16 52 342 2137 0.98942 0.022916 0.032053 4.47 688621;24832;295703;25682;259241;316351;24426;156275;24367;24854;24232;29657;29221;81639;252898;170913 tslp;thy1;serping1;ppard;nr1d2;npas2;gstp1;ggt7;fgg;clu;c3;arntl;arg1;alox15;acox2;abcb1a TSLP_32811;THY1_33010;SERPING1_32597;PPARD_9536;NR1D2_9358;NPAS2_9350;GSTP1_8762;GGT7_33026;FGG_8639;CLU_32773;C3_8175;ARNTL_8086;ARG1_33267;ALOX15_8036;ACOX2_32902;ABCB1A_7938 272.4799000000004 101.8582 5.72311E-12 331.62481006271497 286.35813893966576 328.3675358025605 169.00321812500036 33.5514 5.72311E-12 234.60556136046566 176.78682125349988 228.98153472594902 773.2887562500003 247.279 5.72313E-12 972.640579482562 848.3046944939043 999.1478552934517 344.675;5.72311E-12;32.3997;94.1074;29.1728;21.0878;14.7631;109.609;42.4612;935.649;234.759;22.9134;760.927;766.819;743.353;206.982 244.2;5.72311E-12;13.7308;37.7692;3.35457;11.3305;9.42992;29.3336;20.6424;808.484;129.148;11.4115;413.607;421.048;432.537;118.025 560.435;5.72313E-12;99.4885;148.485;114.038;43.5624;25.7196;346.073;98.0534;1071.05;694.216;50.1592;2639.93;2662.07;2287.79;1531.55 2 14 2 259241;24426 NR1D2_9358;GSTP1_8762 21.96795 21.96795 10.18919658486379 6.392244999999999 6.392244999999999 4.295921183081692 69.8788 69.8788 62.45053954354597 29.1728;14.7631 3.35457;9.42992 114.038;25.7196 14 688621;24832;295703;25682;316351;156275;24367;24854;24232;29657;29221;81639;252898;170913 TSLP_32811;THY1_33010;SERPING1_32597;PPARD_9536;NPAS2_9350;GGT7_33026;FGG_8639;CLU_32773;C3_8175;ARNTL_8086;ARG1_33267;ALOX15_8036;ACOX2_32902;ABCB1A_7938 308.26732142857185 158.2955 340.3706771661697 192.23335714285756 77.8971 242.60421681218733 873.7758928571432 453.25399999999996 1002.1364464567703 344.675;5.72311E-12;32.3997;94.1074;21.0878;109.609;42.4612;935.649;234.759;22.9134;760.927;766.819;743.353;206.982 244.2;5.72311E-12;13.7308;37.7692;11.3305;29.3336;20.6424;808.484;129.148;11.4115;413.607;421.048;432.537;118.025 560.435;5.72313E-12;99.4885;148.485;43.5624;346.073;98.0534;1071.05;694.216;50.1592;2639.93;2662.07;2287.79;1531.55 0 Exp 2,4(0.25);Exp 4,7(0.44);Exp 5,1(0.07);Hill,1(0.07);Poly 2,3(0.19) 2.014574098312768 33.72955334186554 1.5021449327468872 3.5281898975372314 0.7039618834716251 1.875340223312378 109.98374306927005 434.9760569307307 54.04649305837219 283.95994319162855 296.6948723035448 1249.8826401964557 DOWN 0.125 0.875 0.0 GO:0043401 6 steroid hormone mediated signaling pathway 34 37 3 3 3 3 3 3 65 34 2445 0.98419 0.074193 0.074193 8.11 25682;25154;259241 ppard;pgr;nr1d2 PPARD_9536;PGR_32824;NR1D2_9358 135.63273333333333 94.1074 29.1728 132.20762055227127 109.7977475923852 119.25100497060915 59.94492333333334 37.7692 3.35457 70.35028652822697 46.1970591825308 63.44697316139218 605.5776666666667 148.485 114.038 821.7202241860264 447.6631858902575 725.9461039691258 0.5 61.6401 94.1074;283.618;29.1728 37.7692;138.711;3.35457 148.485;1554.21;114.038 1 2 1 259241 NR1D2_9358 29.1728 29.1728 3.35457 3.35457 114.038 114.038 29.1728 3.35457 114.038 2 25682;25154 PPARD_9536;PGR_32824 188.8627 188.8627 134.00423036673135 88.24010000000001 88.24010000000001 71.37663128517625 851.3475000000001 851.3475000000001 993.9976799834594 94.1074;283.618 37.7692;138.711 148.485;1554.21 0 Exp 4,1(0.34);Exp 5,1(0.34);Poly 2,1(0.34) 1.8680578296985715 5.661862134933472 1.5405861139297485 2.1823768615722656 0.3239933223118844 1.9388991594314575 -13.974273083623132 285.2397397502898 -19.663920121359396 139.55376678802605 -324.2863028927627 1535.441636226096 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0071496 4 cellular response to external stimulus 143 149 18 17 13 12 9 9 59 140 2339 0.99466 0.015935 0.015935 6.04 363131;362282;81687;24426;25283;246142;25612;24646;170913 pik3r4;pck1;mmp9;gstp1;gclc;bmf;asns;abcb1b;abcb1a PIK3R4_9484;PCK1_9439;MMP9_32531;GSTP1_8762;GCLC_8699;BMF_8152;ASNS_8091;ABCB1B_7939;ABCB1A_7938 321.9970222222222 191.145 14.7631 335.8309345419611 234.93624677210667 275.74813487421125 211.80720777777776 113.564 8.25355 248.94988629989376 141.6195646324083 190.18293886228048 787.9035666666667 510.267 25.7196 715.0882339838314 701.3445773670895 743.8688388115343 6.5 628.78 955.628;529.244;728.316;14.7631;131.7;119.401;191.145;20.7941;206.982 735.228;356.883;443.137;9.42992;39.9158;81.8286;113.564;8.25355;118.025 1288.97;1021.06;2039.06;25.7196;397.209;220.085;510.267;57.2115;1531.55 2 7 2 362282;24426 PCK1_9439;GSTP1_8762 272.00355 272.00355 363.7929331809581 183.15645999999998 183.15645999999998 245.686429012152 523.3897999999999 523.3897999999999 703.8119464289307 529.244;14.7631 356.883;9.42992 1021.06;25.7196 7 363131;81687;25283;246142;25612;24646;170913 PIK3R4_9484;MMP9_32531;GCLC_8699;BMF_8152;ASNS_8091;ABCB1B_7939;ABCB1A_7938 336.28087142857146 191.145 356.7181757736057 219.99313571428573 113.564 268.74267403949 863.4789285714287 510.267 754.4911850953167 955.628;728.316;131.7;119.401;191.145;20.7941;206.982 735.228;443.137;39.9158;81.8286;113.564;8.25355;118.025 1288.97;2039.06;397.209;220.085;510.267;57.2115;1531.55 0 Exp 4,1(0.12);Hill,2(0.23);Linear,2(0.23);Poly 2,4(0.45) 2.192343375933935 22.154752373695374 1.5018656253814697 6.191005229949951 1.5244732237109877 1.8874764442443848 102.58747832147438 541.4065661229702 49.159948728513825 374.45446682704164 320.7125871305634 1255.0945462027698 DOWN 0.2222222222222222 0.7777777777777778 0.0 GO:0006937 7 regulation of muscle contraction 34 35 5 4 3 3 2 2 66 33 2446 0.93513 0.23954 0.23954 5.71 25154;686019 pgr;casq1 PGR_32824;CASQ1_32992 215.639 215.639 147.66 96.13682375656052 175.58360058484564 77.67508504909982 117.65665000000001 117.65665000000001 96.6023 29.775347316949894 105.25075408101833 24.05740635936855 919.9915000000001 919.9915000000001 285.773 896.9204042079208 546.2896901178292 724.679326368622 0.5 215.639 283.618;147.66 138.711;96.6023 1554.21;285.773 0 2 0 2 25154;686019 PGR_32824;CASQ1_32992 215.639 215.639 96.13682375656052 117.65665000000001 117.65665000000001 29.775347316949894 919.9915000000001 919.9915000000001 896.9204042079208 283.618;147.66 138.711;96.6023 1554.21;285.773 0 Poly 2,2(1) 1.893421924049942 3.8676527738571167 1.5405861139297485 2.327066659927368 0.5561257273462152 1.9338263869285583 82.40016000000003 348.87784 76.39012400000001 158.923176 -323.0767599999997 2163.05976 DOWN 0.0 1.0 0.0 GO:0097305 5 response to alcohol 168 183 10 9 6 6 4 4 64 179 2300 0.45277 0.73256 1.0 2.19 24314;81687;24426;113902 nqo1;mmp9;gstp1;ces1d NQO1_33055;MMP9_32531;GSTP1_8762;CES1D_32914 194.9572 20.2222 11.0684 355.62665080975955 273.80546100685774 391.6187829604584 116.12244749999999 8.584679999999999 4.18343 218.0206663940553 163.41106675136885 240.99912422049408 541.989275 55.92035 17.0564 998.5198127245193 768.1608483121577 1095.3089145723184 25.6813;728.316;14.7631;11.0684 7.73944;443.137;9.42992;4.18343 86.1211;2039.06;25.7196;17.0564 2 2 2 24314;24426 NQO1_33055;GSTP1_8762 20.2222 20.2222 7.720333258350962 8.584679999999999 8.584679999999999 1.1953498714602508 55.92035 55.92035 42.710310243839245 25.6813;14.7631 7.73944;9.42992 86.1211;25.7196 2 81687;113902 MMP9_32531;CES1D_32914 369.6922 369.6922 507.1706417497764 223.660215 223.660215 310.3870459730439 1028.0582 1028.0582 1429.7724571436113 728.316;11.0684 443.137;4.18343 2039.06;17.0564 0 Exp 4,1(0.25);Exp 5,1(0.25);Hill,1(0.25);Linear,1(0.25) 2.249035684407807 9.379282355308533 1.6269687414169312 3.5281898975372314 0.8228811474787792 2.112061858177185 -153.55691779356442 543.4713177935646 -97.5378055661742 329.7827005661742 -436.56014147002895 1520.5386914700289 CONFLICT 0.5 0.5 0.0 GO:0010468 6 regulation of gene expression 723 775 46 43 29 24 17 17 51 758 1721 0.19829 0.86967 0.35274 2.19 688621;360243;25671;25682;25154;362282;259241;316351;24426;25283;312495;24854;306575;114494;24232;29657;29221 tslp;top2a;smad1;ppard;pgr;pck1;nr1d2;npas2;gstp1;gclc;cyp26b1;clu;ckap2;ccna2;c3;arntl;arg1 TSLP_32811;TOP2A_10059;SMAD1_32578;PPARD_9536;PGR_32824;PCK1_9439;NR1D2_9358;NPAS2_9350;GSTP1_8762;GCLC_8699;CYP26B1_8418;CLU_32773;CKAP2_8324;CCNA2_8221;C3_8175;ARNTL_8086;ARG1_33267 210.34187647058823 86.3883 14.384 282.23667203726495 190.93140493193073 271.8255683531809 133.30194352941177 26.6888 3.35457 216.51064233756023 116.84934044534309 205.2262544233351 519.6574117647059 148.485 25.7196 709.9087855367186 473.8172538039449 709.2517197389047 344.675;86.3883;21.9973;94.1074;283.618;529.244;29.1728;21.0878;14.7631;131.7;18.1872;935.649;32.2386;14.384;234.759;22.9134;760.927 244.2;26.6888;5.02186;37.7692;138.711;356.883;3.35457;11.3305;9.42992;39.9158;10.0176;808.484;15.2683;4.89199;129.148;11.4115;413.607 560.435;262.273;80.1461;148.485;1554.21;1021.06;114.038;43.5624;25.7196;397.209;36.7271;1071.05;76.7052;58.2504;694.216;50.1592;2639.93 4 13 4 362282;259241;24426;312495 PCK1_9439;NR1D2_9358;GSTP1_8762;CYP26B1_8418 147.841775 23.68 254.34243676631937 94.9212725 9.723759999999999 174.66712401763368 299.386175 75.38255 482.7180818442055 529.244;29.1728;14.7631;18.1872 356.883;3.35457;9.42992;10.0176 1021.06;114.038;25.7196;36.7271 13 688621;360243;25671;25682;25154;316351;25283;24854;306575;114494;24232;29657;29221 TSLP_32811;TOP2A_10059;SMAD1_32578;PPARD_9536;PGR_32824;NPAS2_9350;GCLC_8699;CLU_32773;CKAP2_8324;CCNA2_8221;C3_8175;ARNTL_8086;ARG1_33267 229.5726769230769 94.1074 297.2117147489512 145.11138076923078 37.7692 232.88026235803113 587.4331769230769 262.273 769.777220123762 344.675;86.3883;21.9973;94.1074;283.618;21.0878;131.7;935.649;32.2386;14.384;234.759;22.9134;760.927 244.2;26.6888;5.02186;37.7692;138.711;11.3305;39.9158;808.484;15.2683;4.89199;129.148;11.4115;413.607 560.435;262.273;80.1461;148.485;1554.21;43.5624;397.209;1071.05;76.7052;58.2504;694.216;50.1592;2639.93 0 Exp 2,2(0.12);Exp 4,9(0.53);Exp 5,1(0.06);Hill,1(0.06);Linear,1(0.06);Poly 2,3(0.18) 1.9803410970576705 35.033605098724365 1.513624906539917 3.5281898975372314 0.6574485158540301 1.9388991594314575 76.17507905555237 344.5086738856241 30.379317355349897 236.22456970347366 182.18819656759894 857.1266269618127 DOWN 0.23529411764705882 0.7647058823529411 0.0 GO:0048871 4 multicellular organismal homeostasis 34 36 3 2 2 2 2 2 66 34 2445 0.93054 0.24955 0.24955 5.56 259241;312495 nr1d2;cyp26b1 NR1D2_9358;CYP26B1_8418 23.68 23.68 18.1872 7.76799225540293 22.6391733530718 7.627257925499055 6.686085 6.686085 3.35457 4.7114736962494 7.317371336047373 4.626114948235697 75.38255 75.38255 36.7271 54.667061649635066 68.05775710584751 53.676647133744744 0.5 23.68 29.1728;18.1872 3.35457;10.0176 114.038;36.7271 2 0 2 259241;312495 NR1D2_9358;CYP26B1_8418 23.68 23.68 7.76799225540293 6.686085 6.686085 4.7114736962494 75.38255 75.38255 54.667061649635066 29.1728;18.1872 3.35457;10.0176 114.038;36.7271 0 0 Exp 4,2(1) 2.1358601316176204 4.272711753845215 2.090334892272949 2.1823768615722656 0.06508350064531065 2.1363558769226074 12.914112000000003 34.445888 0.156315600000001 13.2158544 -0.3821319999999986 151.14723199999997 UP 1.0 0.0 0.0 GO:0007026 8 negative regulation of microtubule depolymerization 9 10 2 2 1 2 1 1 67 9 2470 0.97247 0.23746 0.23746 10.0 306575 ckap2 CKAP2_8324 32.2386 32.2386 32.2386 32.2386 15.2683 15.2683 15.2683 15.268300000000002 76.7052 76.7052 76.7052 76.7052 0.0 32.2386 0.0 32.2386 32.2386 15.2683 76.7052 0 1 0 1 306575 CKAP2_8324 32.2386 32.2386 15.2683 15.2683 76.7052 76.7052 32.2386 15.2683 76.7052 0 Exp 4,1(1) 2.0582168102264404 2.0582168102264404 2.0582168102264404 2.0582168102264404 0.0 2.0582168102264404 32.2386 32.2386 15.2683 15.2683 76.7052 76.7052 DOWN 0.0 1.0 0.0 GO:0051121 8 hepoxilin metabolic process 3 3 2 2 2 2 2 2 66 1 2478 0.99998 0.0020713 0.0020713 66.67 24426;81639 gstp1;alox15 GSTP1_8762;ALOX15_8036 390.79105 390.79105 14.7631 531.7838267213519 474.99559948717945 518.2791005372753 215.23896 215.23896 9.42992 291.0579356269868 261.32611254700856 283.666477807408 1343.8948 1343.8948 25.7196 1864.1812454238673 1639.0759131623934 1816.8400966112847 0.0 14.7631 0.0 14.7631 14.7631;766.819 9.42992;421.048 25.7196;2662.07 1 1 1 24426 GSTP1_8762 14.7631 14.7631 9.42992 9.42992 25.7196 25.7196 14.7631 9.42992 25.7196 1 81639 ALOX15_8036 766.819 766.819 421.048 421.048 2662.07 2662.07 766.819 421.048 2662.07 0 Exp 2,1(0.5);Exp 4,1(0.5) 2.3021408680518034 5.030334830284119 1.5021449327468872 3.5281898975372314 1.4326301335921123 2.5151674151420593 -346.223732 1127.805832 -188.14675839999995 618.6246784 -1239.728592 3927.518192 CONFLICT 0.5 0.5 0.0 GO:0051122 8 hepoxilin biosynthetic process 3 3 2 2 2 2 2 2 66 1 2478 0.99998 0.0020713 0.0020713 66.67 24426;81639 gstp1;alox15 GSTP1_8762;ALOX15_8036 390.79105 390.79105 14.7631 531.7838267213519 474.99559948717945 518.2791005372753 215.23896 215.23896 9.42992 291.0579356269868 261.32611254700856 283.666477807408 1343.8948 1343.8948 25.7196 1864.1812454238673 1639.0759131623934 1816.8400966112847 0.0 14.7631 0.0 14.7631 14.7631;766.819 9.42992;421.048 25.7196;2662.07 1 1 1 24426 GSTP1_8762 14.7631 14.7631 9.42992 9.42992 25.7196 25.7196 14.7631 9.42992 25.7196 1 81639 ALOX15_8036 766.819 766.819 421.048 421.048 2662.07 2662.07 766.819 421.048 2662.07 0 Exp 2,1(0.5);Exp 4,1(0.5) 2.3021408680518034 5.030334830284119 1.5021449327468872 3.5281898975372314 1.4326301335921123 2.5151674151420593 -346.223732 1127.805832 -188.14675839999995 618.6246784 -1239.728592 3927.518192 CONFLICT 0.5 0.5 0.0 GO:0007166 5 cell surface receptor signaling pathway 368 386 20 19 11 10 7 7 61 379 2100 0.16847 0.90978 0.30618 1.81 24832;25671;309186;245920;84032;29397;24232 thy1;smad1;fermt3;cxcl10;col3a1;ccl11;c3 THY1_33010;SMAD1_32578;FERMT3_32542;CXCL10_8408;COL3A1_8354;CCL11_33230;C3_8175 380.7823285714294 234.759 5.72311E-12 364.96916690782024 452.7752257540735 402.248505929582 216.57198000000082 129.148 5.72311E-12 208.45199799874567 258.5291314776678 227.89022827433274 1094.1531571428582 1187.86 5.72313E-12 875.7179357819713 1212.6164611508157 897.139711938829 5.72311E-12;21.9973;539.113;670.528;212.603;986.476;234.759 5.72311E-12;5.02186;334.248;374.802;119.81;552.974;129.148 5.72313E-12;80.1461;1187.86;1955.3;1510.69;2230.86;694.216 1 6 1 29397 CCL11_33230 986.476 986.476 552.974 552.974 2230.86 2230.86 986.476 552.974 2230.86 6 24832;25671;309186;245920;84032;24232 THY1_33010;SMAD1_32578;FERMT3_32542;CXCL10_8408;COL3A1_8354;C3_8175 279.8333833333343 223.68099999999998 272.4723824109905 160.5049766666676 124.479 160.42820237181152 904.7020166666676 941.038 786.6178950337701 5.72311E-12;21.9973;539.113;670.528;212.603;234.759 5.72311E-12;5.02186;334.248;374.802;119.81;129.148 5.72313E-12;80.1461;1187.86;1955.3;1510.69;694.216 0 Exp 2,2(0.29);Exp 4,1(0.15);Hill,1(0.15);Poly 2,2(0.29);Power,1(0.15) 1.7400279462676964 12.221823930740356 1.5467612743377686 1.9814788103103638 0.15636674025212788 1.6932154893875122 110.40938605496473 651.1552710878941 62.14857884022072 370.9953811597809 445.41223166183806 1742.8940826238777 DOWN 0.14285714285714285 0.8571428571428571 0.0 GO:0018193 7 peptidyl-amino acid modification 169 184 10 10 6 5 3 3 65 181 2298 0.26343 0.88064 0.48021 1.63 315852;291463;288583 ttk;ppic;plod3 TTK_32727;PPIC_9541;PLOD3_9507 749.5526666666666 737.351 628.678 127.41443443477453 728.0133406530891 111.51439611640548 487.1803333333334 446.625 389.239 123.32592289268818 462.11716156559334 104.78259872315472 1574.6566666666668 1509.86 1106.02 504.1676578612841 1697.1053851405165 486.38749539435736 737.351;628.678;882.629 446.625;389.239;625.677 2108.09;1509.86;1106.02 0 3 0 3 315852;291463;288583 TTK_32727;PPIC_9541;PLOD3_9507 749.5526666666666 737.351 127.41443443477453 487.1803333333334 446.625 123.32592289268818 1574.6566666666668 1509.86 504.1676578612841 737.351;628.678;882.629 446.625;389.239;625.677 2108.09;1509.86;1106.02 0 Exp 2,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 1.76970421203251 5.364488840103149 1.5111545324325562 2.13726544380188 0.31922074794491057 1.7160688638687134 605.3696609483277 893.7356723850057 347.623913964234 626.7367527024327 1004.1372540201514 2145.1760793131816 DOWN 0.0 1.0 0.0 GO:0051241 5 negative regulation of multicellular organismal process 326 344 28 27 16 18 11 11 57 333 2146 0.80138 0.30676 0.47422 3.2 24832;295703;25154;81687;24426;24367;245920;84032;29397;29657;29221 thy1;serping1;pgr;mmp9;gstp1;fgg;cxcl10;col3a1;ccl11;arntl;arg1 THY1_33010;SERPING1_32597;PGR_32824;MMP9_32531;GSTP1_8762;FGG_8639;CXCL10_8408;COL3A1_8354;CCL11_33230;ARNTL_8086;ARG1_33267 341.3641272727278 212.603 5.72311E-12 371.4306831549216 398.4704205046939 394.15675075330796 190.75051090909145 119.81 5.72311E-12 211.63259920342682 225.41237665878384 226.2216488372988 1109.406427272728 1510.69 5.72313E-12 1053.9812409496758 1218.4823567621609 1101.0225246244215 5.72311E-12;32.3997;283.618;728.316;14.7631;42.4612;670.528;212.603;986.476;22.9134;760.927 5.72311E-12;13.7308;138.711;443.137;9.42992;20.6424;374.802;119.81;552.974;11.4115;413.607 5.72313E-12;99.4885;1554.21;2039.06;25.7196;98.0534;1955.3;1510.69;2230.86;50.1592;2639.93 2 9 2 24426;29397 GSTP1_8762;CCL11_33230 500.61955 500.61955 687.1047809564456 281.20196000000004 281.20196000000004 384.3437048418033 1128.2898 1128.2898 1559.2697303084162 14.7631;986.476 9.42992;552.974 25.7196;2230.86 9 24832;295703;25154;81687;24367;245920;84032;29657;29221 THY1_33010;SERPING1_32597;PGR_32824;MMP9_32531;FGG_8639;CXCL10_8408;COL3A1_8354;ARNTL_8086;ARG1_33267 305.974033333334 212.603 325.09572355666967 170.65018888888952 119.81 187.13776717011422 1105.210122222223 1510.69 1041.4275554837159 5.72311E-12;32.3997;283.618;728.316;42.4612;670.528;212.603;22.9134;760.927 5.72311E-12;13.7308;138.711;443.137;20.6424;374.802;119.81;11.4115;413.607 5.72313E-12;99.4885;1554.21;2039.06;98.0534;1955.3;1510.69;50.1592;2639.93 0 Exp 2,2(0.19);Exp 4,4(0.37);Hill,1(0.1);Linear,1(0.1);Poly 2,2(0.19);Power,1(0.1) 2.0771569751716545 23.924155235290527 1.513624906539917 3.5281898975372314 0.7395484751181108 1.863204002380371 121.86262046959149 560.8656340758641 65.68363700615963 315.81738481202325 486.5433170805136 1732.269537464942 DOWN 0.18181818181818182 0.8181818181818182 0.0 GO:0016310 6 phosphorylation 244 262 14 14 12 10 8 8 60 254 2225 0.73923 0.4001 0.68417 3.05 684352;315852;24832;25671;363131;362282;114494;29397 twf2;ttk;thy1;smad1;pik3r4;pck1;ccna2;ccl11 TWF2_10109;TTK_32727;THY1_33010;SMAD1_32578;PIK3R4_9484;PCK1_9439;CCNA2_8221;CCL11_33230 422.93491250000073 333.8215 5.72311E-12 430.7798615584504 421.12932281015463 449.582726190762 274.04501875000074 223.80964999999998 5.72311E-12 288.0120710124599 259.2348927251428 281.09405305130633 885.8176875000008 660.1125 5.72313E-12 921.7002434916197 954.9739681285511 1026.5160840006338 138.399;737.351;5.72311E-12;21.9973;955.628;529.244;14.384;986.476 90.7363;446.625;5.72311E-12;5.02186;735.228;356.883;4.89199;552.974 299.165;2108.09;5.72313E-12;80.1461;1288.97;1021.06;58.2504;2230.86 2 6 2 362282;29397 PCK1_9439;CCL11_33230 757.86 757.86 323.3118477754875 454.9285 454.9285 138.65727582965147 1625.96 1625.96 855.4577838794855 529.244;986.476 356.883;552.974 1021.06;2230.86 6 684352;315852;24832;25671;363131;114494 TWF2_10109;TTK_32727;THY1_33010;SMAD1_32578;PIK3R4_9484;CCNA2_8221 311.2932166666676 80.19815 423.1632391862991 213.75052500000095 47.87908 307.9547394550223 639.1035833333343 189.65555 866.4967364385537 138.399;737.351;5.72311E-12;21.9973;955.628;14.384 90.7363;446.625;5.72311E-12;5.02186;735.228;4.89199 299.165;2108.09;5.72313E-12;80.1461;1288.97;58.2504 0 Exp 4,2(0.25);Hill,1(0.13);Linear,2(0.25);Poly 2,2(0.25);Power,1(0.13) 1.690646996364141 13.583784818649292 1.5018656253814697 1.9814788103103638 0.1702795267711996 1.6600053310394287 124.41969841955 721.4501265804515 74.46283604303872 473.6272014569628 247.1120049536687 1524.5233700463327 DOWN 0.25 0.75 0.0 GO:0071396 6 cellular response to lipid 195 209 21 21 14 17 13 13 55 196 2283 0.99908 0.0028412 0.0028412 6.22 116669;684352;25682;362282;81687;24426;25315;312495;245920;113902;114494;29221;170913 vwf;twf2;ppard;pck1;mmp9;gstp1;ephx1;cyp26b1;cxcl10;ces1d;ccna2;arg1;abcb1a VWF_32396;TWF2_10109;PPARD_9536;PCK1_9439;MMP9_32531;GSTP1_8762;EPHX1_8567;CYP26B1_8418;CXCL10_8408;CES1D_32914;CCNA2_8221;ARG1_33267;ABCB1A_7938 249.67850769230773 94.1074 11.0684 303.09602681168957 226.8191301794258 303.8865037712799 145.11981384615385 37.7692 4.11644 179.28163511180168 129.4916390463089 178.64475307009016 765.2367692307691 148.485 17.0564 951.2507084557261 769.308994099453 986.8941239106807 9.5 599.886 19.6764;138.399;94.1074;529.244;728.316;14.7631;39.2381;18.1872;670.528;11.0684;14.384;760.927;206.982 4.11644;90.7363;37.7692;356.883;443.137;9.42992;18.9587;10.0176;374.802;4.18343;4.89199;413.607;118.025 94.078;299.165;148.485;1021.06;2039.06;25.7196;81.6965;36.7271;1955.3;17.0564;58.2504;2639.93;1531.55 4 9 4 362282;24426;25315;312495 PCK1_9439;GSTP1_8762;EPHX1_8567;CYP26B1_8418 150.3581 28.712650000000004 252.8222896625348 98.822305 14.488150000000001 172.09570189636182 291.3008 59.2118 487.108336713802 529.244;14.7631;39.2381;18.1872 356.883;9.42992;18.9587;10.0176 1021.06;25.7196;81.6965;36.7271 9 116669;684352;25682;81687;245920;113902;114494;29221;170913 VWF_32396;TWF2_10109;PPARD_9536;MMP9_32531;CXCL10_8408;CES1D_32914;CCNA2_8221;ARG1_33267;ABCB1A_7938 293.8209111111111 138.399 326.6599814074279 165.69648444444445 90.7363 188.56949407615502 975.8749777777778 299.165 1051.7208531224026 19.6764;138.399;94.1074;728.316;670.528;11.0684;14.384;760.927;206.982 4.11644;90.7363;37.7692;443.137;374.802;4.18343;4.89199;413.607;118.025 94.078;299.165;148.485;2039.06;1955.3;17.0564;58.2504;2639.93;1531.55 0 Exp 2,2(0.16);Exp 4,4(0.31);Exp 5,2(0.16);Hill,1(0.08);Linear,2(0.16);Poly 2,2(0.16) 1.9282290599642127 25.663232445716858 1.513624906539917 3.5281898975372314 0.5077765701872542 1.8874764442443848 84.91363065572679 414.44338472888853 47.66120683357944 242.57842085872824 248.1309936837854 1282.3425447777531 DOWN 0.3076923076923077 0.6923076923076923 0.0 GO:0071373 7 cellular response to luteinizing hormone stimulus 5 6 2 2 2 2 2 2 66 4 2475 0.99966 0.0098306 0.0098306 33.33 25154;114494 pgr;ccna2 PGR_32824;CCNA2_8221 149.001 149.001 14.384 190.37718712597894 93.82682614605214 173.6522227242389 71.801495 71.801495 4.89199 94.62432942267043 44.37794031261585 86.31141880021526 806.2302 806.2302 58.2504 1057.8031775411155 499.662920054368 964.8733430609186 0.0 14.384 0.0 14.384 283.618;14.384 138.711;4.89199 1554.21;58.2504 0 2 0 2 25154;114494 PGR_32824;CCNA2_8221 149.001 149.001 190.37718712597894 71.801495 71.801495 94.62432942267043 806.2302 806.2302 1057.8031775411155 283.618;14.384 138.711;4.89199 1554.21;58.2504 0 Exp 4,1(0.5);Poly 2,1(0.5) 1.583103930023621 3.1673812866210938 1.5405861139297485 1.6267951726913452 0.06095901005003456 1.5836906433105469 -114.84831999999997 412.85032 -59.341134800000006 202.9441248 -659.8102079999999 2272.270608 DOWN 0.0 1.0 0.0 GO:0008610 5 lipid biosynthetic process 109 122 10 10 9 8 7 7 61 115 2364 0.9855 0.041652 0.041652 5.74 25682;24426;64191;312495;24296;113902;81639 ppard;gstp1;dhcr7;cyp26b1;cyp1a1;ces1d;alox15 PPARD_9536;GSTP1_8762;DHCR7_8466;CYP26B1_8418;CYP1A1_8415;CES1D_32914;ALOX15_8036 154.21905714285714 18.1872 11.0684 276.0941218646391 180.6839344152483 276.67670470154053 77.49831571428571 10.0176 4.18343 152.50566244211674 87.13423492494596 154.27132195620035 484.41407142857145 36.7271 17.0564 974.7306333456999 572.0457879791736 979.5573208416263 5.5 464.2605 94.1074;14.7631;161.702;18.1872;12.8863;11.0684;766.819 37.7692;9.42992;50.9087;10.0176;9.13136;4.18343;421.048 148.485;25.7196;481.517;36.7271;19.3234;17.0564;2662.07 3 4 3 24426;312495;24296 GSTP1_8762;CYP26B1_8418;CYP1A1_8415 15.278866666666667 14.7631 2.6878237746052673 9.526293333333333 9.42992 0.45091152007169494 27.2567 25.7196 8.80307904826488 14.7631;18.1872;12.8863 9.42992;10.0176;9.13136 25.7196;36.7271;19.3234 4 25682;64191;113902;81639 PPARD_9536;DHCR7_8466;CES1D_32914;ALOX15_8036 258.4242 127.90469999999999 344.48287775338457 128.4773325 44.33895 196.036924863347 827.2821 315.001 1238.7132208160372 94.1074;161.702;11.0684;766.819 37.7692;50.9087;4.18343;421.048 148.485;481.517;17.0564;2662.07 0 Exp 2,1(0.15);Exp 4,4(0.58);Exp 5,2(0.29) 2.671176890309039 27.96654462814331 1.5021449327468872 15.48720932006836 5.112332795830923 1.9388991594314575 -50.31433062930964 358.75244491502394 -35.47946006399549 190.47609149256692 -237.67648688200563 1206.5046297391486 CONFLICT 0.42857142857142855 0.5714285714285714 0.0 GO:1901564 4 organonitrogen compound metabolic process 832 911 54 54 34 36 26 26 42 885 1594 0.71433 0.37741 0.701 2.85 315852;24832;25671;291463;25682;288583;363131;362282;81687;291234;362376;24426;156275;25283;81919;24367;29243;24296;84032;297594;114494;29397;116599;25612;29657;29221 ttk;thy1;smad1;ppic;ppard;plod3;pik3r4;pck1;mmp9;mki67;herc6;gstp1;ggt7;gclc;fut1;fgg;f10;cyp1a1;col3a1;cdca3;ccna2;ccl11;blvra;asns;arntl;arg1 TTK_32727;THY1_33010;SMAD1_32578;PPIC_9541;PPARD_9536;PLOD3_9507;PIK3R4_9484;PCK1_9439;MMP9_32531;MKI67_9232;HERC6_8794;GSTP1_8762;GGT7_33026;GCLC_8699;FUT1_8668;FGG_8639;F10_8585;CYP1A1_8415;COL3A1_8354;CDCA3_8260;CCNA2_8221;CCL11_33230;BLVRA_8151;ASNS_8091;ARNTL_8086;ARG1_33267 306.0436346153848 120.65449999999998 5.72311E-12 342.296808913012 272.0046352264767 319.5972576770963 185.179275769231 39.169349999999994 5.72311E-12 229.3828211458389 152.8493416754538 203.20573619219948 742.4705192307695 371.64099999999996 5.72313E-12 814.9973838225159 725.8041602457437 836.8976863316044 737.351;5.72311E-12;21.9973;628.678;94.1074;882.629;955.628;529.244;728.316;21.9311;39.6865;14.7631;109.609;131.7;240.861;42.4612;104.19;12.8863;212.603;56.6562;14.384;986.476;415.991;191.145;22.9134;760.927 446.625;5.72311E-12;5.02186;389.239;37.7692;625.677;735.228;356.883;443.137;6.82654;15.7729;9.42992;29.3336;39.9158;78.9726;20.6424;38.4229;9.13136;119.81;22.3266;4.89199;552.974;288.048;113.564;11.4115;413.607 2108.09;5.72313E-12;80.1461;1509.86;148.485;1106.02;1288.97;1021.06;2039.06;76.1794;157.407;25.7196;346.073;397.209;847.87;98.0534;163.044;19.3234;1510.69;150.565;58.2504;2230.86;720.942;510.267;50.1592;2639.93 4 22 4 362282;24426;24296;29397 PCK1_9439;GSTP1_8762;CYP1A1_8415;CCL11_33230 385.84235 272.00355 468.3733694917656 232.10457000000002 183.15645999999998 269.46112881831175 824.2407499999999 523.3897999999999 1049.2606125218956 529.244;14.7631;12.8863;986.476 356.883;9.42992;9.13136;552.974 1021.06;25.7196;19.3234;2230.86 22 315852;24832;25671;291463;25682;288583;363131;81687;291234;362376;156275;25283;81919;24367;29243;84032;297594;114494;116599;25612;29657;29221 TTK_32727;THY1_33010;SMAD1_32578;PPIC_9541;PPARD_9536;PLOD3_9507;PIK3R4_9484;MMP9_32531;MKI67_9232;HERC6_8794;GGT7_33026;GCLC_8699;FUT1_8668;FGG_8639;F10_8585;COL3A1_8354;CDCA3_8260;CCNA2_8221;BLVRA_8151;ASNS_8091;ARNTL_8086;ARG1_33267 291.5347772727275 120.65449999999998 326.66819502326064 176.64740409090936 39.169349999999994 227.53070863161756 727.6032045454548 371.64099999999996 794.9563208844813 737.351;5.72311E-12;21.9973;628.678;94.1074;882.629;955.628;728.316;21.9311;39.6865;109.609;131.7;240.861;42.4612;104.19;212.603;56.6562;14.384;415.991;191.145;22.9134;760.927 446.625;5.72311E-12;5.02186;389.239;37.7692;625.677;735.228;443.137;6.82654;15.7729;29.3336;39.9158;78.9726;20.6424;38.4229;119.81;22.3266;4.89199;288.048;113.564;11.4115;413.607 2108.09;5.72313E-12;80.1461;1509.86;148.485;1106.02;1288.97;2039.06;76.1794;157.407;346.073;397.209;847.87;98.0534;163.044;1510.69;150.565;58.2504;720.942;510.267;50.1592;2639.93 0 Exp 2,4(0.16);Exp 4,10(0.39);Exp 5,2(0.08);Hill,2(0.08);Linear,3(0.12);Poly 2,4(0.16);Power,1(0.04) 2.0899063398537234 65.22437584400177 1.5018656253814697 15.48720932006836 2.703375244944508 1.8926228284835815 174.46897723644412 437.6182919943255 97.0073579628091 273.3511935756528 429.1956105872837 1055.7454278742555 DOWN 0.15384615384615385 0.8461538461538461 0.0 GO:0019637 4 organophosphate metabolic process 156 173 5 5 4 4 3 3 65 170 2309 0.30993 0.85252 0.62388 1.73 25682;362282;81639 ppard;pck1;alox15 PPARD_9536;PCK1_9439;ALOX15_8036 463.3901333333333 529.244 94.1074 341.1565227426457 477.42628850009834 384.56655581530026 271.90006666666665 356.883 37.7692 205.28573708568584 264.6610320031453 222.61960745268377 1277.2050000000002 1021.06 148.485 1276.219057930495 1490.8669608806763 1449.8318615592548 94.1074;529.244;766.819 37.7692;356.883;421.048 148.485;1021.06;2662.07 1 2 1 362282 PCK1_9439 529.244 529.244 356.883 356.883 1021.06 1021.06 529.244 356.883 1021.06 2 25682;81639 PPARD_9536;ALOX15_8036 430.4632 430.4632 475.6789341428522 229.4086 229.4086 271.0190385650425 1405.2775000000001 1405.2775000000001 1777.372998588788 94.1074;766.819 37.7692;421.048 148.485;2662.07 0 Exp 2,1(0.34);Exp 5,1(0.34);Linear,1(0.34) 1.674266540581965 5.052456617355347 1.5021449327468872 1.9388991594314575 0.2272814543312697 1.611412525177002 77.33518526045748 849.4450814062092 39.59738655493217 504.2027467784011 -166.97281661655984 2721.3828166165595 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0002009 5 morphogenesis of an epithelium 84 87 4 4 3 3 2 2 66 85 2394 0.5875 0.6836 1.0 2.3 288583;29397 plod3;ccl11 PLOD3_9507;CCL11_33230 934.5525 934.5525 882.629 73.43091790587978 958.840187831892 64.90235854004861 589.3255 589.3255 552.974 51.4087843126055 572.3217563343953 45.4379632819179 1668.44 1668.44 1106.02 795.381991749876 1931.517053557882 703.0031583020136 882.629;986.476 625.677;552.974 1106.02;2230.86 1 1 1 29397 CCL11_33230 986.476 986.476 552.974 552.974 2230.86 2230.86 986.476 552.974 2230.86 1 288583 PLOD3_9507 882.629 882.629 625.677 625.677 1106.02 1106.02 882.629 625.677 1106.02 0 Poly 2,1(0.5);Power,1(0.5) 1.8440049053050906 3.697547674179077 1.7160688638687134 1.9814788103103638 0.1876731729232494 1.8487738370895386 832.7824400000001 1036.32256 518.0765600000001 660.57444 566.0968 2770.7832 CONFLICT 0.5 0.5 0.0 GO:1902531 6 regulation of intracellular signal transduction 377 399 26 25 15 14 11 11 57 388 2091 0.62552 0.50576 0.86617 2.76 25682;81687;24426;24367;29243;84032;24854;29397;24232;29657;81639 ppard;mmp9;gstp1;fgg;f10;col3a1;clu;ccl11;c3;arntl;alox15 PPARD_9536;MMP9_32531;GSTP1_8762;FGG_8639;F10_8585;COL3A1_8354;CLU_32773;CCL11_33230;C3_8175;ARNTL_8086;ALOX15_8036 376.64155454545454 212.603 14.7631 391.0436761706788 427.48910323737863 399.55219680696456 235.66153818181817 119.81 9.42992 275.09274867993895 263.98006110902094 275.09535991454146 972.1279272727272 694.216 25.7196 989.8712147606932 1089.5205046504507 1041.4088916657868 94.1074;728.316;14.7631;42.4612;104.19;212.603;935.649;986.476;234.759;22.9134;766.819 37.7692;443.137;9.42992;20.6424;38.4229;119.81;808.484;552.974;129.148;11.4115;421.048 148.485;2039.06;25.7196;98.0534;163.044;1510.69;1071.05;2230.86;694.216;50.1592;2662.07 2 9 2 24426;29397 GSTP1_8762;CCL11_33230 500.61955 500.61955 687.1047809564456 281.20196000000004 281.20196000000004 384.3437048418033 1128.2898 1128.2898 1559.2697303084162 14.7631;986.476 9.42992;552.974 25.7196;2230.86 9 25682;81687;24367;29243;84032;24854;24232;29657;81639 PPARD_9536;MMP9_32531;FGG_8639;F10_8585;COL3A1_8354;CLU_32773;C3_8175;ARNTL_8086;ALOX15_8036 349.09088888888886 212.603 356.97796630195694 225.54144444444444 119.81 274.76592619839215 937.425288888889 694.216 955.7403287031897 94.1074;728.316;42.4612;104.19;212.603;935.649;234.759;22.9134;766.819 37.7692;443.137;20.6424;38.4229;119.81;808.484;129.148;11.4115;421.048 148.485;2039.06;98.0534;163.044;1510.69;1071.05;694.216;50.1592;2662.07 0 Exp 2,1(0.1);Exp 4,3(0.28);Exp 5,2(0.19);Linear,1(0.1);Poly 2,3(0.28);Power,1(0.1) 2.0285191021357725 23.499785900115967 1.5021449327468872 3.5281898975372314 0.7692548656888036 1.9388991594314575 145.54950954738277 607.7335995435263 73.0921124871791 398.2309638764574 387.1514214669385 1557.104433078516 DOWN 0.18181818181818182 0.8181818181818182 0.0 GO:0019547 9 arginine catabolic process to ornithine 1 1 1 1 1 1 1 1 67 0 2479 1.0 0.026698 0.026698 100.0 29221 arg1 ARG1_33267 760.927 760.927 760.927 760.927 413.607 413.607 413.607 413.607 2639.93 2639.93 2639.93 2639.93 0.0 760.927 0.0 760.927 760.927 413.607 2639.93 0 1 0 1 29221 ARG1_33267 760.927 760.927 413.607 413.607 2639.93 2639.93 760.927 413.607 2639.93 0 Exp 2,1(1) 1.513624906539917 1.513624906539917 1.513624906539917 1.513624906539917 0.0 1.513624906539917 760.927 760.927 413.607 413.607 2639.93 2639.93 DOWN 0.0 1.0 0.0 GO:0098813 4 nuclear chromosome segregation 19 19 4 4 3 2 2 2 66 17 2462 0.98701 0.089736 0.089736 10.53 315852;360243 ttk;top2a TTK_32727;TOP2A_10059 411.86965 411.86965 86.3883 460.3001394695042 310.4752761613158 437.39522208566393 236.6569 236.6569 26.6888 296.9397346857102 171.2473641676144 282.1637667731343 1185.1815000000001 1185.1815000000001 262.273 1305.1897175294093 897.6758427084246 1240.2423927584393 0.0 86.3883 0.5 411.86965 737.351;86.3883 446.625;26.6888 2108.09;262.273 0 2 0 2 315852;360243 TTK_32727;TOP2A_10059 411.86965 411.86965 460.3001394695042 236.6569 236.6569 296.9397346857102 1185.1815000000001 1185.1815000000001 1305.1897175294093 737.351;86.3883 446.625;26.6888 2108.09;262.273 0 Exp 4,1(0.5);Linear,1(0.5) 1.7211532251135357 3.4714890718460083 1.5111545324325562 1.9603345394134521 0.31761822890961233 1.7357445359230042 -226.07379600000002 1049.8130959999999 -174.8805759999999 648.1943759999999 -623.7191599999996 2994.08216 DOWN 0.0 1.0 0.0 GO:1901216 7 positive regulation of neuron death 58 61 4 4 2 2 2 2 66 59 2420 0.77857 0.48934 0.67744 3.28 24314;24854 nqo1;clu NQO1_33055;CLU_32773 480.66515 480.66515 25.6813 643.444331330726 344.4275098912946 613.9211825282351 408.11172 408.11172 7.73944 566.2119083742384 288.2266414589884 540.2324139398042 578.58555 578.58555 86.1211 696.4499041766068 431.12494341927953 664.494701289105 25.6813;935.649 7.73944;808.484 86.1211;1071.05 1 1 1 24314 NQO1_33055 25.6813 25.6813 7.73944 7.73944 86.1211 86.1211 25.6813 7.73944 86.1211 1 24854 CLU_32773 935.649 935.649 808.484 808.484 1071.05 1071.05 935.649 808.484 1071.05 0 Hill,1(0.5);Poly 2,1(0.5) 1.8380321647263949 3.727636218070984 1.5548590421676636 2.1727771759033203 0.43693410258261883 1.863818109035492 -411.1031959999999 1372.433496 -376.61794879999997 1192.8413888 -386.6447719999999 1543.815872 CONFLICT 0.5 0.5 0.0 GO:0006996 5 organelle organization 397 425 26 25 14 18 9 9 59 416 2063 0.27897 0.82517 0.51254 2.12 360243;24832;295661;316273;293502;25283;312495;29397;686019 top2a;thy1;spc25;mcm3;kif22;gclc;cyp26b1;ccl11;casq1 TOP2A_10059;THY1_33010;SPC25_9925;MCM3_9207;KIF22_8963;GCLC_8699;CYP26B1_8418;CCL11_33230;CASQ1_32992 180.0982777777784 86.3883 5.72311E-12 309.97234669951075 147.1644680589886 268.6491838670153 95.25633777777843 26.6888 5.72311E-12 176.61749995537025 74.91097257703113 153.57746184768334 436.04391111111175 262.273 5.72313E-12 693.3272220127326 363.51489714615286 599.6988115418361 86.3883;5.72311E-12;35.8903;197.273;17.3097;131.7;18.1872;986.476;147.66 26.6888;5.72311E-12;11.5744;116.413;3.12114;39.9158;10.0176;552.974;96.6023 262.273;5.72313E-12;124.006;496.915;90.6321;397.209;36.7271;2230.86;285.773 2 7 2 312495;29397 CYP26B1_8418;CCL11_33230 502.3316 502.3316 684.6835766269847 281.49580000000003 281.49580000000003 383.9281523286356 1133.79355 1133.79355 1551.486252414505 18.1872;986.476 10.0176;552.974 36.7271;2230.86 7 360243;24832;295661;316273;293502;25283;686019 TOP2A_10059;THY1_33010;SPC25_9925;MCM3_9207;KIF22_8963;GCLC_8699;CASQ1_32992 88.03161428571511 86.3883 74.0143275069401 42.04506285714367 26.6888 46.47356084377701 236.68687142857223 262.273 176.3518173065287 86.3883;5.72311E-12;35.8903;197.273;17.3097;131.7;147.66 26.6888;5.72311E-12;11.5744;116.413;3.12114;39.9158;96.6023 262.273;5.72313E-12;124.006;496.915;90.6321;397.209;285.773 0 Exp 4,3(0.34);Hill,3(0.34);Poly 2,2(0.23);Power,1(0.12) 1.901073128386136 17.224648118019104 1.57428777217865 2.327066659927368 0.2334046989246208 1.9603345394134521 -22.416988732568626 382.61354428812547 -20.133762193063475 210.64643774862031 -16.92987393720682 889.0176961594304 DOWN 0.2222222222222222 0.7777777777777778 0.0 GO:0006355 7 regulation of transcription, DNA-templated 466 499 26 24 17 16 12 12 56 487 1992 0.41058 0.70648 0.75879 2.4 360243;25671;25682;25154;362282;259241;316351;25283;24854;306575;114494;29657 top2a;smad1;ppard;pgr;pck1;nr1d2;npas2;gclc;clu;ckap2;ccna2;arntl TOP2A_10059;SMAD1_32578;PPARD_9536;PGR_32824;PCK1_9439;NR1D2_9358;NPAS2_9350;GCLC_8699;CLU_32773;CKAP2_8324;CCNA2_8221;ARNTL_8086 183.54171666666664 59.31345 14.384 281.05994219136966 145.51876956864362 250.8475704851823 121.64421 20.97855 3.35457 238.74083180544727 91.08506653413887 218.5992044970153 406.42902499999997 131.2615 43.5624 513.8795508783606 317.7643642737865 410.51374190257417 86.3883;21.9973;94.1074;283.618;529.244;29.1728;21.0878;131.7;935.649;32.2386;14.384;22.9134 26.6888;5.02186;37.7692;138.711;356.883;3.35457;11.3305;39.9158;808.484;15.2683;4.89199;11.4115 262.273;80.1461;148.485;1554.21;1021.06;114.038;43.5624;397.209;1071.05;76.7052;58.2504;50.1592 2 10 2 362282;259241 PCK1_9439;NR1D2_9358 279.20840000000004 279.20840000000004 353.6037365960942 180.118785 180.118785 249.98235019523364 567.549 567.549 641.3614068853847 529.244;29.1728 356.883;3.35457 1021.06;114.038 10 360243;25671;25682;25154;316351;25283;24854;306575;114494;29657 TOP2A_10059;SMAD1_32578;PPARD_9536;PGR_32824;NPAS2_9350;GCLC_8699;CLU_32773;CKAP2_8324;CCNA2_8221;ARNTL_8086 164.40838 59.31345 283.2236896275247 109.949295 20.97855 248.6120571989307 374.20502999999997 114.31555 519.7378094826918 86.3883;21.9973;94.1074;283.618;21.0878;131.7;935.649;32.2386;14.384;22.9134 26.6888;5.02186;37.7692;138.711;11.3305;39.9158;808.484;15.2683;4.89199;11.4115 262.273;80.1461;148.485;1554.21;43.5624;397.209;1071.05;76.7052;58.2504;50.1592 0 Exp 4,7(0.59);Exp 5,1(0.09);Hill,1(0.09);Linear,1(0.09);Poly 2,2(0.17) 1.9878290763493254 24.66883158683777 1.5405861139297485 3.442979335784912 0.6073181859612518 1.9496168494224548 24.51708404971089 342.5663492836224 -13.436131839241554 256.72455183924154 115.67429790994777 697.1837520900522 DOWN 0.16666666666666666 0.8333333333333334 0.0 GO:1902893 9 regulation of pri-miRNA transcription by RNA polymerase II 35 36 3 3 2 2 2 2 66 34 2445 0.93054 0.24955 0.24955 5.56 25671;25682 smad1;ppard SMAD1_32578;PPARD_9536 58.05235 58.05235 21.9973 50.98954070204007 77.76432738491675 42.6943691387759 21.39553 21.39553 5.02186 23.155866179821473 30.347324901077375 19.38878218547751 114.31555 114.31555 80.1461 48.32289960882938 132.99663422135166 40.46154731636617 0.5 58.05235 21.9973;94.1074 5.02186;37.7692 80.1461;148.485 0 2 0 2 25671;25682 SMAD1_32578;PPARD_9536 58.05235 58.05235 50.98954070204007 21.39553 21.39553 23.155866179821473 114.31555 114.31555 48.32289960882938 21.9973;94.1074 5.02186;37.7692 80.1461;148.485 0 Exp 4,1(0.5);Exp 5,1(0.5) 1.8118979245834383 3.6321146488189697 1.6932154893875122 1.9388991594314575 0.17372458911487199 1.8160573244094849 -12.61554799999999 128.720248 -10.6968632 53.4879232 47.34342799999999 181.28767200000001 DOWN 0.0 1.0 0.0 GO:0006725 4 cellular aromatic compound metabolic process 429 482 27 27 17 17 12 12 56 470 2009 0.46626 0.65662 0.87622 2.49 360243;25682;299112;362282;300795;313108;291234;316273;293502;25315;24296;116599 top2a;ppard;pole2;pck1;pclaf;mms22l;mki67;mcm3;kif22;ephx1;cyp1a1;blvra TOP2A_10059;PPARD_9536;POLE2_9520;PCK1_9439;NS5ATP9_9367;MMS22L_33129;MKI67_9232;MCM3_9207;KIF22_8963;EPHX1_8567;CYP1A1_8415;BLVRA_8151 152.76982502263317 90.24785 2.71598E-7 173.79128682884863 92.08420552027981 120.39448331525594 91.41181168929984 32.229 2.71598E-7 118.8350469725503 51.840341467915685 81.38211144527523 318.0405333559666 194.4855 2.71599E-7 330.12339488046086 202.61966838135996 228.99795780357917 86.3883;94.1074;2.71598E-7;529.244;292.216;126.653;21.9311;197.273;17.3097;39.2381;12.8863;415.991 26.6888;37.7692;2.71598E-7;356.883;147.515;85.587;6.82654;116.413;3.12114;18.9587;9.13136;288.048 262.273;148.485;2.71599E-7;1021.06;658.494;240.486;76.1794;496.915;90.6321;81.6965;19.3234;720.942 3 9 3 362282;25315;24296 PCK1_9439;EPHX1_8567;CYP1A1_8415 193.7894666666667 39.2381 290.8107843447752 128.32435333333333 18.9587 197.99857418032718 374.02663333333334 81.6965 561.2145169949752 529.244;39.2381;12.8863 356.883;18.9587;9.13136 1021.06;81.6965;19.3234 9 360243;25682;299112;300795;313108;291234;316273;293502;116599 TOP2A_10059;PPARD_9536;POLE2_9520;NS5ATP9_9367;MMS22L_33129;MKI67_9232;MCM3_9207;KIF22_8963;BLVRA_8151 139.0966111412887 94.1074 139.80578339657131 79.10763114128866 37.7692 94.5267413230745 299.3785000301777 240.486 263.7078811362343 86.3883;94.1074;2.71598E-7;292.216;126.653;21.9311;197.273;17.3097;415.991 26.6888;37.7692;2.71598E-7;147.515;85.587;6.82654;116.413;3.12114;288.048 262.273;148.485;2.71599E-7;658.494;240.486;76.1794;496.915;90.6321;720.942 0 Exp 2,2(0.17);Exp 4,4(0.34);Exp 5,1(0.09);Hill,2(0.17);Linear,1(0.09);Poly 2,2(0.17) 2.097764163025768 34.82731306552887 1.540663719177246 15.48720932006836 3.9672826705432955 1.763019621372223 54.43814771385493 251.10150233141147 24.174554257711364 158.64906912088833 131.25563907394002 504.8254276379933 DOWN 0.25 0.75 0.0 GO:0009267 5 cellular response to starvation 53 55 7 7 5 5 4 4 64 51 2428 0.98552 0.057185 0.057185 7.27 363131;362282;246142;25612 pik3r4;pck1;bmf;asns PIK3R4_9484;PCK1_9439;BMF_8152;ASNS_8091 448.85450000000003 360.1945 119.401 382.2022357622554 266.91173211871876 299.6744747742257 321.8759 235.2235 81.8286 301.71841704019323 184.20988927416983 234.25851641752058 760.0954999999999 765.6635 220.085 483.679069402085 507.19200987364087 399.0782683246563 1.5 360.1945 955.628;529.244;119.401;191.145 735.228;356.883;81.8286;113.564 1288.97;1021.06;220.085;510.267 1 3 1 362282 PCK1_9439 529.244 529.244 356.883 356.883 1021.06 1021.06 529.244 356.883 1021.06 3 363131;246142;25612 PIK3R4_9484;BMF_8152;ASNS_8091 422.058 191.145 463.47546759132786 310.20686666666666 113.564 368.42096403197974 673.1073333333334 510.267 552.7354850435543 955.628;119.401;191.145 735.228;81.8286;113.564 1288.97;220.085;510.267 0 Linear,1(0.25);Poly 2,3(0.75) 1.6269012371403802 6.522045135498047 1.5018656253814697 1.805381178855896 0.12679345375987858 1.6073991656303406 74.29630895298965 823.4126910470103 26.19185130061055 617.5599486993893 286.0900119859571 1234.100988014043 DOWN 0.25 0.75 0.0 GO:0050790 4 regulation of catalytic activity 528 565 34 32 20 17 12 12 56 553 1926 0.22562 0.85658 0.45915 2.12 24832;295703;363131;304545;24314;81687;24426;361921;24854;114494;29397;24232 thy1;serping1;pik3r4;oasl;nqo1;mmp9;gstp1;ect2;clu;ccna2;ccl11;c3 THY1_33010;SERPING1_32597;PIK3R4_9484;OASL_9389;NQO1_33055;MMP9_32531;GSTP1_8762;ECT2_8523;CLU_32773;CCNA2_8221;CCL11_33230;C3_8175 334.5570750000005 54.506150000000005 5.72311E-12 427.7124675586199 321.41091481239783 422.9025256918489 228.0420750000005 21.08925 5.72311E-12 314.81301767926 211.4945870644202 298.0885725643947 657.6545916666672 179.93875 5.72313E-12 816.0609565214654 687.7520077928762 893.972528390257 5.72311E-12;32.3997;955.628;76.6126;25.6813;728.316;14.7631;10.0162;935.649;14.384;986.476;234.759 5.72311E-12;13.7308;735.228;28.4477;7.73944;443.137;9.42992;3.29405;808.484;4.89199;552.974;129.148 5.72313E-12;99.4885;1288.97;260.389;86.1211;2039.06;25.7196;37.7305;1071.05;58.2504;2230.86;694.216 3 9 3 24314;24426;29397 NQO1_33055;GSTP1_8762;CCL11_33230 342.3068 25.6813 557.8936013652514 190.04778666666667 9.42992 314.30445697446254 780.9002333333334 86.1211 1256.0651173464707 25.6813;14.7631;986.476 7.73944;9.42992;552.974 86.1211;25.7196;2230.86 9 24832;295703;363131;304545;81687;361921;24854;114494;24232 THY1_33010;SERPING1_32597;PIK3R4_9484;OASL_9389;MMP9_32531;ECT2_8523;CLU_32773;CCNA2_8221;C3_8175 331.97383333333397 76.6126 416.77132970566674 240.70683777777842 28.4477 332.9472086479501 616.5727111111119 260.389 716.7071596507793 5.72311E-12;32.3997;955.628;76.6126;728.316;10.0162;935.649;14.384;234.759 5.72311E-12;13.7308;735.228;28.4477;443.137;3.29405;808.484;4.89199;129.148 5.72313E-12;99.4885;1288.97;260.389;2039.06;37.7305;1071.05;58.2504;694.216 0 Exp 4,5(0.42);Hill,2(0.17);Linear,1(0.09);Poly 2,3(0.25);Power,1(0.09) 1.8688413002403392 23.07417404651642 1.5018656253814697 3.5281898975372314 0.55020161085062 1.790760576725006 92.55596488488678 576.5581851151143 49.91984210851169 406.16430789148933 195.92463900231184 1119.3845443310227 DOWN 0.25 0.75 0.0 GO:1905039 6 carboxylic acid transmembrane transport 23 23 3 3 3 3 3 3 65 20 2459 0.99719 0.021998 0.021998 13.04 313089;294881;170551 slc7a13;slc7a12;slc5a6 SLC7A13_32952;SLC7A12_32838;SLC5A6_9881 185.3081 120.077 37.9163 188.6636381485049 168.3883016990291 171.24947917248 125.90899999999999 82.2177 15.3983 137.65863814919135 114.25086949375864 124.73686519844568 340.5216666666667 221.286 132.15 287.19545655238585 311.278916851595 262.05119433585065 0.5 78.99665 1.5 259.004 397.931;37.9163;120.077 280.111;15.3983;82.2177 668.129;132.15;221.286 0 3 0 3 313089;294881;170551 SLC7A13_32952;SLC7A12_32838;SLC5A6_9881 185.3081 120.077 188.6636381485049 125.90899999999999 82.2177 137.65863814919135 340.5216666666667 221.286 287.19545655238585 397.931;37.9163;120.077 280.111;15.3983;82.2177 668.129;132.15;221.286 0 Exp 2,1(0.34);Exp 4,1(0.34);Poly 2,1(0.34) 1.9032052857787982 5.805081725120544 1.517665982246399 2.3742122650146484 0.4286899708791602 1.913203477859497 -28.184904451813622 398.8011044518136 -29.866413511757315 281.68441351175727 15.529413331574005 665.5139200017593 DOWN 0.0 1.0 0.0 GO:0016132 6 brassinosteroid biosynthetic process 1 1 1 1 1 1 1 1 67 0 2479 1.0 0.026698 0.026698 100.0 64191 dhcr7 DHCR7_8466 161.702 161.702 161.702 161.702 50.9087 50.9087 50.9087 50.9087 481.517 481.517 481.517 481.51700000000005 0.0 161.702 0.0 161.702 161.702 50.9087 481.517 0 1 0 1 64191 DHCR7_8466 161.702 161.702 50.9087 50.9087 481.517 481.517 161.702 50.9087 481.517 0 Exp 4,1(1) 1.7927976846694946 1.7927976846694946 1.7927976846694946 1.7927976846694946 0.0 1.7927976846694946 161.702 161.702 50.9087 50.9087 481.517 481.517 DOWN 0.0 1.0 0.0 GO:0060548 6 negative regulation of cell death 321 341 27 26 17 19 15 15 53 326 2153 0.98514 0.031546 0.044919 4.4 688621;24832;25671;25682;25154;24314;316351;81687;24426;25283;24367;24854;246142;25612;170913 tslp;thy1;smad1;ppard;pgr;nqo1;npas2;mmp9;gstp1;gclc;fgg;clu;bmf;asns;abcb1a TSLP_32811;THY1_33010;SMAD1_32578;PPARD_9536;PGR_32824;NQO1_33055;NPAS2_9350;MMP9_32531;GSTP1_8762;GCLC_8699;FGG_8639;CLU_32773;BMF_8152;ASNS_8091;ABCB1A_7938 210.7722733333337 119.401 5.72311E-12 275.4468659822366 214.78222880269115 262.115291284344 138.6532480000004 39.9158 5.72311E-12 220.03104151096264 137.38748123107183 202.59863116354595 557.7302400000004 220.085 5.72313E-12 667.0251915979544 576.66910823276 663.8417402198348 344.675;5.72311E-12;21.9973;94.1074;283.618;25.6813;21.0878;728.316;14.7631;131.7;42.4612;935.649;119.401;191.145;206.982 244.2;5.72311E-12;5.02186;37.7692;138.711;7.73944;11.3305;443.137;9.42992;39.9158;20.6424;808.484;81.8286;113.564;118.025 560.435;5.72313E-12;80.1461;148.485;1554.21;86.1211;43.5624;2039.06;25.7196;397.209;98.0534;1071.05;220.085;510.267;1531.55 2 13 2 24314;24426 NQO1_33055;GSTP1_8762 20.2222 20.2222 7.720333258350962 8.584679999999999 8.584679999999999 1.1953498714602508 55.92035 55.92035 42.710310243839245 25.6813;14.7631 7.73944;9.42992 86.1211;25.7196 13 688621;24832;25671;25682;25154;316351;81687;25283;24367;24854;246142;25612;170913 TSLP_32811;THY1_33010;SMAD1_32578;PPARD_9536;PGR_32824;NPAS2_9350;MMP9_32531;GCLC_8699;FGG_8639;CLU_32773;BMF_8152;ASNS_8091;ABCB1A_7938 240.08766923076968 131.7 285.5321490357529 158.66379692307737 81.8286 230.71422595325078 634.931761538462 397.209 685.9291150877754 344.675;5.72311E-12;21.9973;94.1074;283.618;21.0878;728.316;131.7;42.4612;935.649;119.401;191.145;206.982 244.2;5.72311E-12;5.02186;37.7692;138.711;11.3305;443.137;39.9158;20.6424;808.484;81.8286;113.564;118.025 560.435;5.72313E-12;80.1461;148.485;1554.21;43.5624;2039.06;397.209;98.0534;1071.05;220.085;510.267;1531.55 0 Exp 2,1(0.07);Exp 4,4(0.27);Exp 5,1(0.07);Hill,3(0.2);Linear,1(0.07);Poly 2,5(0.34) 2.014152680472099 31.201978087425232 1.5405861139297485 3.5281898975372314 0.5945632475767664 1.8874764442443848 71.37692637067451 350.16762029599283 27.302177569037937 250.00431843096283 220.168918748201 895.2915612517996 DOWN 0.13333333333333333 0.8666666666666667 0.0 GO:1901605 7 alpha-amino acid metabolic process 67 72 4 4 4 4 4 4 64 68 2411 0.95885 0.12381 0.12381 5.56 288583;25283;25612;29221 plod3;gclc;asns;arg1 PLOD3_9507;GCLC_8699;ASNS_8091;ARG1_33267 491.60024999999996 476.036 131.7 385.24534554607754 356.8596838586013 342.3987466142095 298.19095000000004 263.5855 39.9158 271.6377129658975 196.110409851558 222.20565291888113 1163.3564999999999 808.1435 397.209 1032.3217621621986 1016.1319546650022 1063.0171442280478 2.5 821.778 882.629;131.7;191.145;760.927 625.677;39.9158;113.564;413.607 1106.02;397.209;510.267;2639.93 0 4 0 4 288583;25283;25612;29221 PLOD3_9507;GCLC_8699;ASNS_8091;ARG1_33267 491.60024999999996 476.036 385.24534554607754 298.19095000000004 263.5855 271.6377129658975 1163.3564999999999 808.1435 1032.3217621621986 882.629;131.7;191.145;760.927 625.677;39.9158;113.564;413.607 1106.02;397.209;510.267;2639.93 0 Exp 2,1(0.25);Hill,1(0.25);Poly 2,2(0.5) 1.7444364615883228 7.009764075279236 1.513624906539917 1.9746891260147095 0.1919661001640923 1.7607250213623047 114.059811364844 869.1406886351559 31.985991293420398 564.3959087065796 151.68117308104547 2175.0318269189543 DOWN 0.0 1.0 0.0 GO:0000724 8 double-strand break repair via homologous recombination 15 15 3 3 3 2 2 2 66 13 2466 0.99342 0.058963 0.058963 13.33 313108;316273 mms22l;mcm3 MMS22L_33129;MCM3_9207 161.963 161.963 126.653 49.93588088739405 138.3760996184824 37.16057670145519 101.0 101.0 85.587 21.79727363685648 90.70419440440864 16.220786425928388 368.70050000000003 368.70050000000003 240.486 181.32268479288507 283.05386621449765 134.9341478756365 0.0 126.653 0.5 161.963 126.653;197.273 85.587;116.413 240.486;496.915 0 2 0 2 313108;316273 MMS22L_33129;MCM3_9207 161.963 161.963 49.93588088739405 101.0 101.0 21.79727363685648 368.70050000000003 368.70050000000003 181.32268479288507 126.653;197.273 85.587;116.413 240.486;496.915 0 Poly 2,2(1) 1.5573850051095328 3.114951491355896 1.540663719177246 1.57428777217865 0.02377579588826852 1.557475745677948 92.75540000000001 231.17059999999998 70.79052000000001 131.20947999999999 117.40008000000006 620.00092 DOWN 0.0 1.0 0.0 GO:0046395 6 carboxylic acid catabolic process 80 87 6 6 6 6 6 6 62 81 2398 0.99241 0.026782 0.026782 6.9 25682;362282;312495;113902;29221;252898 ppard;pck1;cyp26b1;ces1d;arg1;acox2 PPARD_9536;PCK1_9439;CYP26B1_8418;CES1D_32914;ARG1_33267;ACOX2_32902 359.4811666666667 311.6757 11.0684 359.3416270912662 344.18270939410786 377.1999452618762 209.166205 197.3261 4.18343 211.92727077342016 192.41938420511394 215.32728015545445 1025.17475 584.7725 17.0564 1180.1326196877192 1065.356551435983 1283.091654946984 3.5 636.2985 94.1074;529.244;18.1872;11.0684;760.927;743.353 37.7692;356.883;10.0176;4.18343;413.607;432.537 148.485;1021.06;36.7271;17.0564;2639.93;2287.79 2 4 2 362282;312495 PCK1_9439;CYP26B1_8418 273.7156 273.7156 361.3717288514972 183.4503 183.4503 245.27087649898422 528.89355 528.89355 696.0284685350197 529.244;18.1872 356.883;10.0176 1021.06;36.7271 4 25682;113902;29221;252898 PPARD_9536;CES1D_32914;ARG1_33267;ACOX2_32902 402.36395 418.73019999999997 405.3703249757806 222.0241575 225.68810000000002 232.68298485196956 1273.3153499999999 1218.1375 1383.259951807501 94.1074;11.0684;760.927;743.353 37.7692;4.18343;413.607;432.537 148.485;17.0564;2639.93;2287.79 0 Exp 2,2(0.34);Exp 4,1(0.17);Exp 5,2(0.34);Linear,1(0.17) 1.705836568546297 10.313206553459167 1.513624906539917 2.090334892272949 0.238096819865466 1.6191906332969666 71.94798095974232 647.014352373591 39.58907084799483 378.74333915200515 80.87198596402277 1969.477514035977 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0010639 7 negative regulation of organelle organization 85 89 8 8 6 6 5 5 63 84 2395 0.97043 0.08657 0.08657 5.62 684352;315852;360243;25283;306575 twf2;ttk;top2a;gclc;ckap2 TWF2_10109;TTK_32727;TOP2A_10059;GCLC_8699;CKAP2_8324 225.21538 131.7 32.2386 289.4296543057259 172.28694592533247 244.05315137694228 123.84684 39.9158 15.2683 182.72619680325806 86.7725799551354 154.5955211719114 628.6884400000001 299.165 76.7052 835.1262144571131 488.3271260567217 700.4974741099526 3.5 437.875 138.399;737.351;86.3883;131.7;32.2386 90.7363;446.625;26.6888;39.9158;15.2683 299.165;2108.09;262.273;397.209;76.7052 0 5 0 5 684352;315852;360243;25283;306575 TWF2_10109;TTK_32727;TOP2A_10059;GCLC_8699;CKAP2_8324 225.21538 131.7 289.4296543057259 123.84684 39.9158 182.72619680325806 628.6884400000001 299.165 835.1262144571131 138.399;737.351;86.3883;131.7;32.2386 90.7363;446.625;26.6888;39.9158;15.2683 299.165;2108.09;262.273;397.209;76.7052 0 Exp 4,2(0.4);Hill,1(0.2);Linear,1(0.2);Poly 2,1(0.2) 1.8489371852680252 9.29905366897583 1.5111545324325562 2.0582168102264404 0.21706738067498813 1.9603345394134521 -28.480897638892202 478.91165763889217 -36.319733350259156 284.01341335025916 -103.33196224472351 1360.7088422447237 DOWN 0.0 1.0 0.0 GO:0043065 8 positive regulation of apoptotic process 196 210 18 18 9 11 6 6 62 204 2275 0.67313 0.49494 0.82237 2.86 360243;24314;81687;361921;24854;246142 top2a;nqo1;mmp9;ect2;clu;bmf TOP2A_10059;NQO1_33055;MMP9_32531;ECT2_8523;CLU_32773;BMF_8152 317.5753 102.89465 10.0162 405.76796587371956 264.27440631249686 368.8552121434825 228.52864833333334 54.2587 3.29405 329.8920071450517 179.5105183139326 286.45308416110873 619.3865999999999 241.17900000000003 37.7305 791.0929392672014 572.1027672221937 796.2157296513441 86.3883;25.6813;728.316;10.0162;935.649;119.401 26.6888;7.73944;443.137;3.29405;808.484;81.8286 262.273;86.1211;2039.06;37.7305;1071.05;220.085 1 5 1 24314 NQO1_33055 25.6813 25.6813 7.73944 7.73944 86.1211 86.1211 25.6813 7.73944 86.1211 5 360243;81687;361921;24854;246142 TOP2A_10059;MMP9_32531;ECT2_8523;CLU_32773;BMF_8152 375.95410000000004 119.401 424.5573229739654 272.68649 81.8286 348.4416136425162 726.0397 262.273 834.8493397918872 86.3883;728.316;10.0162;935.649;119.401 26.6888;443.137;3.29405;808.484;81.8286 262.273;2039.06;37.7305;1071.05;220.085 0 Exp 4,2(0.34);Hill,1(0.17);Linear,1(0.17);Poly 2,2(0.34) 1.8140204545835896 10.978538513183594 1.5548590421676636 2.1727771759033203 0.26390666810786945 1.7980849742889404 -7.106693650172474 642.2572936501725 -35.43993365779994 492.49723032446667 -13.6195865055804 1252.3927865055805 DOWN 0.16666666666666666 0.8333333333333334 0.0 GO:0051983 5 regulation of chromosome segregation 25 27 4 4 4 3 3 3 65 24 2455 0.99487 0.033686 0.033686 11.11 315852;291234;361921 ttk;mki67;ect2 TTK_32727;MKI67_9232;ECT2_8523 256.4327666666667 21.9311 10.0162 416.5300128140148 201.92376048636217 387.3645906629065 152.24853 6.82654 3.29405 254.94361962725347 119.0776142280644 236.94674221972429 740.6666333333334 76.1794 37.7305 1184.3794059579486 585.4412259480777 1101.6288502927196 0.5 15.97365 1.5 379.64105 737.351;21.9311;10.0162 446.625;6.82654;3.29405 2108.09;76.1794;37.7305 0 3 0 3 315852;291234;361921 TTK_32727;MKI67_9232;ECT2_8523 256.4327666666667 21.9311 416.5300128140148 152.24853 6.82654 254.94361962725347 740.6666333333334 76.1794 1184.3794059579486 737.351;21.9311;10.0162 446.625;6.82654;3.29405 2108.09;76.1794;37.7305 0 Exp 4,2(0.67);Linear,1(0.34) 1.681139526952759 5.069031596183777 1.5111545324325562 1.922041654586792 0.21066860353549932 1.6358354091644287 -214.91531477984358 727.780848113177 -136.2473341431458 440.7443941431458 -599.5848336175095 2080.918100284176 DOWN 0.0 1.0 0.0 GO:0070887 4 cellular response to chemical stimulus 594 635 51 50 33 36 27 27 41 608 1871 0.99791 0.004602 0.0065327 4.25 116669;684352;25671;25682;288583;25154;362282;24314;81687;24426;25283;24367;25315;361921;312495;24296;245920;84032;24854;113902;114494;29397;25612;29221;81639;24646;170913 vwf;twf2;smad1;ppard;plod3;pgr;pck1;nqo1;mmp9;gstp1;gclc;fgg;ephx1;ect2;cyp26b1;cyp1a1;cxcl10;col3a1;clu;ces1d;ccna2;ccl11;asns;arg1;alox15;abcb1b;abcb1a VWF_32396;TWF2_10109;SMAD1_32578;PPARD_9536;PLOD3_9507;PGR_32824;PCK1_9439;NQO1_33055;MMP9_32531;GSTP1_8762;GCLC_8699;FGG_8639;EPHX1_8567;ECT2_8523;CYP26B1_8418;CYP1A1_8415;CXCL10_8408;COL3A1_8354;CLU_32773;CES1D_32914;CCNA2_8221;CCL11_33230;ASNS_8091;ARG1_33267;ALOX15_8036;ABCB1B_7939;ABCB1A_7938 287.7887407407407 131.7 10.0162 343.92526505124994 244.2464997212759 328.9097491350401 176.3268162962963 39.9158 3.29405 231.79544661081127 144.76565220540414 215.7440349846911 791.4459259259258 299.165 17.0564 901.6424535057341 712.1185306131929 909.3934700258789 19.6764;138.399;21.9973;94.1074;882.629;283.618;529.244;25.6813;728.316;14.7631;131.7;42.4612;39.2381;10.0162;18.1872;12.8863;670.528;212.603;935.649;11.0684;14.384;986.476;191.145;760.927;766.819;20.7941;206.982 4.11644;90.7363;5.02186;37.7692;625.677;138.711;356.883;7.73944;443.137;9.42992;39.9158;20.6424;18.9587;3.29405;10.0176;9.13136;374.802;119.81;808.484;4.18343;4.89199;552.974;113.564;413.607;421.048;8.25355;118.025 94.078;299.165;80.1461;148.485;1106.02;1554.21;1021.06;86.1211;2039.06;25.7196;397.209;98.0534;81.6965;37.7305;36.7271;19.3234;1955.3;1510.69;1071.05;17.0564;58.2504;2230.86;510.267;2639.93;2662.07;57.2115;1531.55 7 20 7 362282;24314;24426;25315;312495;24296;29397 PCK1_9439;NQO1_33055;GSTP1_8762;EPHX1_8567;CYP26B1_8418;CYP1A1_8415;CCL11_33230 232.3537142857143 25.6813 382.5855695287588 137.87628857142857 10.0176 223.89305943798138 500.21538571428573 81.6965 845.0115158906168 529.244;25.6813;14.7631;39.2381;18.1872;12.8863;986.476 356.883;7.73944;9.42992;18.9587;10.0176;9.13136;552.974 1021.06;86.1211;25.7196;81.6965;36.7271;19.3234;2230.86 20 116669;684352;25671;25682;288583;25154;81687;25283;24367;361921;245920;84032;24854;113902;114494;25612;29221;81639;24646;170913 VWF_32396;TWF2_10109;SMAD1_32578;PPARD_9536;PLOD3_9507;PGR_32824;MMP9_32531;GCLC_8699;FGG_8639;ECT2_8523;CXCL10_8408;COL3A1_8354;CLU_32773;CES1D_32914;CCNA2_8221;ASNS_8091;ARG1_33267;ALOX15_8036;ABCB1B_7939;ABCB1A_7938 307.19100000000003 164.772 337.80473415953276 189.784501 102.15015 238.66045648381692 893.3766149999999 453.738 919.1290583100146 19.6764;138.399;21.9973;94.1074;882.629;283.618;728.316;131.7;42.4612;10.0162;670.528;212.603;935.649;11.0684;14.384;191.145;760.927;766.819;20.7941;206.982 4.11644;90.7363;5.02186;37.7692;625.677;138.711;443.137;39.9158;20.6424;3.29405;374.802;119.81;808.484;4.18343;4.89199;113.564;413.607;421.048;8.25355;118.025 94.078;299.165;80.1461;148.485;1106.02;1554.21;2039.06;397.209;98.0534;37.7305;1955.3;1510.69;1071.05;17.0564;58.2504;510.267;2639.93;2662.07;57.2115;1531.55 0 Exp 2,3(0.12);Exp 4,8(0.3);Exp 5,2(0.08);Hill,4(0.15);Linear,2(0.08);Poly 2,7(0.26);Power,1(0.04) 2.1117702080162744 69.34910678863525 1.5021449327468872 15.48720932006836 2.7435084935892133 1.8538048267364502 158.0593824265518 417.51809905492973 88.89306947781107 263.7605631147814 451.3444306062969 1131.5474212455551 DOWN 0.25925925925925924 0.7407407407407407 0.0 GO:0071456 5 cellular response to hypoxia 57 60 5 5 4 4 3 3 65 57 2422 0.92587 0.21436 0.21436 5.0 25682;362282;114494 ppard;pck1;ccna2 PPARD_9536;PCK1_9439;CCNA2_8221 212.57846666666669 94.1074 14.384 277.12226566599327 100.86490762860035 191.48159932560645 133.18139666666664 37.7692 4.89199 194.42744979753766 56.15878959694487 131.9406780679399 409.2651333333333 148.485 58.2504 531.7473929593386 198.59244980215328 360.8774524376804 2.0 529.244 94.1074;529.244;14.384 37.7692;356.883;4.89199 148.485;1021.06;58.2504 1 2 1 362282 PCK1_9439 529.244 529.244 356.883 356.883 1021.06 1021.06 529.244 356.883 1021.06 2 25682;114494 PPARD_9536;CCNA2_8221 54.2457 54.2457 56.37295675924759 21.330595 21.330595 23.247698137494172 103.36770000000001 103.36770000000001 63.80549755765564 94.1074;14.384 37.7692;4.89199 148.485;58.2504 0 Exp 4,1(0.34);Exp 5,1(0.34);Linear,1(0.34) 1.71935257789307 5.177106857299805 1.611412525177002 1.9388991594314575 0.18479403850365153 1.6267951726913452 -101.0148981075057 526.171831440839 -86.83397467111652 353.19676800444984 -192.46368757994014 1010.9939542466068 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0051641 3 cellular localization 308 325 13 12 10 7 5 5 63 320 2159 0.11644 0.94746 0.20085 1.54 315852;24832;363131;293502;29657 ttk;thy1;pik3r4;kif22;arntl TTK_32727;THY1_33010;PIK3R4_9484;KIF22_8963;ARNTL_8086 346.6404200000012 22.9134 5.72311E-12 462.85476051072544 252.2417845325819 411.588401678068 239.27712800000114 11.4115 5.72311E-12 336.86286027718495 164.17392736061134 286.5372106101177 707.5702600000011 90.6321 5.72313E-12 950.3866144512854 601.3685755238554 945.1896119891068 737.351;5.72311E-12;955.628;17.3097;22.9134 446.625;5.72311E-12;735.228;3.12114;11.4115 2108.09;5.72313E-12;1288.97;90.6321;50.1592 0 5 0 5 315852;24832;363131;293502;29657 TTK_32727;THY1_33010;PIK3R4_9484;KIF22_8963;ARNTL_8086 346.6404200000012 22.9134 462.85476051072544 239.27712800000114 11.4115 336.86286027718495 707.5702600000011 90.6321 950.3866144512854 737.351;5.72311E-12;955.628;17.3097;22.9134 446.625;5.72311E-12;735.228;3.12114;11.4115 2108.09;5.72313E-12;1288.97;90.6321;50.1592 0 Exp 4,1(0.2);Hill,2(0.4);Linear,1(0.2);Poly 2,1(0.2) 1.9343024383928207 10.17909288406372 1.5018656253814697 3.442979335784912 0.8064158955141806 1.8598893880844116 -59.069665618854856 752.3505056188571 -55.99618783252015 534.5504438325224 -125.48033732903025 1540.6208573290323 DOWN 0.0 1.0 0.0 GO:0042745 5 circadian sleep/wake cycle 2 2 1 1 1 1 1 1 67 1 2478 0.9993 0.052694 0.052694 50.0 316351 npas2 NPAS2_9350 21.0878 21.0878 21.0878 21.0878 11.3305 11.3305 11.3305 11.3305 43.5624 43.5624 43.5624 43.5624 0.0 21.0878 0.0 21.0878 21.0878 11.3305 43.5624 0 1 0 1 316351 NPAS2_9350 21.0878 21.0878 11.3305 11.3305 43.5624 43.5624 21.0878 11.3305 43.5624 0 Exp 4,1(1) 3.08446741104126 3.0844674110412598 3.0844674110412598 3.0844674110412598 0.0 3.0844674110412598 21.0878 21.0878 11.3305 11.3305 43.5624 43.5624 DOWN 0.0 1.0 0.0 GO:0009409 4 response to cold 23 27 2 2 2 2 2 2 66 25 2454 0.96631 0.16114 0.16114 7.41 116669;245920 vwf;cxcl10 VWF_32396;CXCL10_8408 345.10220000000004 345.10220000000004 19.6764 460.22157990611436 106.54633815208194 313.02732175845944 189.45922000000002 189.45922000000002 4.11644 262.11427316393286 53.59228314315254 178.28135947016912 1024.689 1024.689 94.078 1316.082697493588 342.4975168718864 895.1554207716833 0.5 345.10220000000004 19.6764;670.528 4.11644;374.802 94.078;1955.3 0 2 0 2 116669;245920 VWF_32396;CXCL10_8408 345.10220000000004 345.10220000000004 460.22157990611436 189.45922000000002 189.45922000000002 262.11427316393286 1024.689 1024.689 1316.082697493588 19.6764;670.528 4.11644;374.802 94.078;1955.3 0 Exp 2,1(0.5);Hill,1(0.5) 1.968969486518798 3.9450933933258057 1.8538048267364502 2.0912885665893555 0.16792636287153126 1.9725466966629028 -292.7323679999999 982.9367679999998 -173.8126287999999 552.7310688 -799.3085599999997 2848.68656 DOWN 0.0 1.0 0.0 GO:0032890 6 regulation of organic acid transport 33 35 4 3 3 2 2 2 66 33 2446 0.93513 0.23954 0.23954 5.71 113902;29221 ces1d;arg1 CES1D_32914;ARG1_33267 385.9977 385.9977 11.0684 530.2301009910508 580.8318355236729 453.0157605055988 208.895215 208.895215 4.18343 289.50618272460514 315.2748542065997 247.34707307813417 1328.4932 1328.4932 17.0564 1854.651708755172 2009.9887652223813 1584.5695156580969 0.5 385.9977 11.0684;760.927 4.18343;413.607 17.0564;2639.93 0 2 0 2 113902;29221 CES1D_32914;ARG1_33267 385.9977 385.9977 530.2301009910508 208.895215 208.895215 289.50618272460514 1328.4932 1328.4932 1854.651708755172 11.0684;760.927 4.18343;413.607 17.0564;2639.93 0 Exp 2,1(0.5);Exp 5,1(0.5) 1.5692738477303982 3.140593647956848 1.513624906539917 1.6269687414169312 0.08014619424722502 1.570296823978424 -348.8637279999999 1120.859128 -192.3398836 610.1303136 -1241.9229279999995 3898.9093279999993 DOWN 0.0 1.0 0.0 GO:0035690 5 cellular response to drug 160 174 15 15 10 11 7 7 61 167 2312 0.91125 0.17882 0.22547 4.02 362282;24314;25283;361921;114494;29221;170913 pck1;nqo1;gclc;ect2;ccna2;arg1;abcb1a PCK1_9439;NQO1_33055;GCLC_8699;ECT2_8523;CCNA2_8221;ARG1_33267;ABCB1A_7938 239.84778571428572 131.7 10.0162 293.70438082444076 182.55622492555526 265.44315836612617 134.90804 39.9158 3.29405 176.37688072194769 93.63818180693188 151.483463330817 824.5501428571428 397.209 37.7305 980.4987929345348 726.1125912179642 972.0897927639223 529.244;25.6813;131.7;10.0162;14.384;760.927;206.982 356.883;7.73944;39.9158;3.29405;4.89199;413.607;118.025 1021.06;86.1211;397.209;37.7305;58.2504;2639.93;1531.55 2 5 2 362282;24314 PCK1_9439;NQO1_33055 277.46265 277.46265 356.0725999226071 182.31122 182.31122 246.8817788836122 553.59055 553.59055 661.1016361850914 529.244;25.6813 356.883;7.73944 1021.06;86.1211 5 25283;361921;114494;29221;170913 GCLC_8699;ECT2_8523;CCNA2_8221;ARG1_33267;ABCB1A_7938 224.80184 131.7 310.9759737642573 115.94676800000002 39.9158 172.7790781945064 932.93398 397.209 1131.9936441537786 131.7;10.0162;14.384;760.927;206.982 39.9158;3.29405;4.89199;413.607;118.025 397.209;37.7305;58.2504;2639.93;1531.55 0 Exp 2,1(0.15);Exp 4,2(0.29);Hill,2(0.29);Linear,1(0.15);Poly 2,1(0.15) 1.761218659223434 12.422610759735107 1.513624906539917 2.1727771759033203 0.2405416870706179 1.6358354091644287 22.268535537415886 457.4270358911556 4.2462182447587224 265.5698617552413 98.18647212408064 1550.9138135902049 DOWN 0.2857142857142857 0.7142857142857143 0.0 GO:0006778 5 porphyrin-containing compound metabolic process 14 15 4 4 3 3 2 2 66 13 2466 0.99342 0.058963 0.058963 13.33 24296;116599 cyp1a1;blvra CYP1A1_8415;BLVRA_8151 214.43865 214.43865 12.8863 285.0380668981689 180.01701387826088 280.8504967317134 148.58968 148.58968 9.13136 197.22384752976706 124.77262430608697 194.3263794511463 370.1327 370.1327 19.3234 496.11926986661183 310.2205725913044 488.8306495215991 0.0 12.8863 0.5 214.43865 12.8863;415.991 9.13136;288.048 19.3234;720.942 1 1 1 24296 CYP1A1_8415 12.8863 12.8863 9.13136 9.13136 19.3234 19.3234 12.8863 9.13136 19.3234 1 116599 BLVRA_8151 415.991 415.991 288.048 288.048 720.942 720.942 415.991 288.048 720.942 0 Exp 2,1(0.5);Exp 4,1(0.5) 4.928902446010319 17.055863738059998 1.5686544179916382 15.48720932006836 9.841904555575713 8.527931869029999 -180.60395599999987 609.4812559999998 -124.74862720000002 421.9279872000001 -317.453528 1057.718928 CONFLICT 0.5 0.5 0.0 GO:1901074 8 regulation of engulfment of apoptotic cell 1 1 1 1 1 1 1 1 67 0 2479 1.0 0.026698 0.026698 100.0 81639 alox15 ALOX15_8036 766.819 766.819 766.819 766.819 421.048 421.048 421.048 421.048 2662.07 2662.07 2662.07 2662.07 0.0 766.819 0.0 766.819 766.819 421.048 2662.07 0 1 0 1 81639 ALOX15_8036 766.819 766.819 421.048 421.048 2662.07 2662.07 766.819 421.048 2662.07 0 Exp 2,1(1) 1.5021449327468872 1.5021449327468872 1.5021449327468872 1.5021449327468872 0.0 1.5021449327468872 766.819 766.819 421.048 421.048 2662.07 2662.07 DOWN 0.0 1.0 0.0 GO:0032502 2 developmental process 992 1073 78 75 49 52 38 38 30 1035 1444 0.99258 0.014256 0.024517 3.54 116669;360243;24832;25671;295703;25682;288583;25154;362282;338475;259241;24314;81687;291234;362376;24426;25283;81919;24367;309186;25315;361921;64191;312495;24296;84032;24854;113902;114494;29397;686019;24232;25612;29657;29221;81639;24646;170913 vwf;top2a;thy1;smad1;serping1;ppard;plod3;pgr;pck1;nrep;nr1d2;nqo1;mmp9;mki67;herc6;gstp1;gclc;fut1;fgg;fermt3;ephx1;ect2;dhcr7;cyp26b1;cyp1a1;col3a1;clu;ces1d;ccna2;ccl11;casq1;c3;asns;arntl;arg1;alox15;abcb1b;abcb1a VWF_32396;TOP2A_10059;THY1_33010;SMAD1_32578;SERPING1_32597;PPARD_9536;PLOD3_9507;PGR_32824;PCK1_9439;NREP_9364;NR1D2_9358;NQO1_33055;MMP9_32531;MKI67_9232;HERC6_8794;GSTP1_8762;GCLC_8699;FUT1_8668;FGG_8639;FERMT3_32542;EPHX1_8567;ECT2_8523;DHCR7_8466;CYP26B1_8418;CYP1A1_8415;COL3A1_8354;CLU_32773;CES1D_32914;CCNA2_8221;CCL11_33230;CASQ1_32992;C3_8175;ASNS_8091;ARNTL_8086;ARG1_33267;ALOX15_8036;ABCB1B_7939;ABCB1A_7938 225.77628421052648 73.96565 5.72311E-12 301.94171094854875 203.16956738938993 280.9859835118294 133.9111144736844 26.18035 5.72311E-12 204.9946363358748 114.15461818059356 185.03374094849875 618.9511605263159 153.09750000000003 5.72313E-12 782.4275766647593 589.0061060054519 775.6120544631299 19.6764;86.3883;5.72311E-12;21.9973;32.3997;94.1074;882.629;283.618;529.244;61.543;29.1728;25.6813;728.316;21.9311;39.6865;14.7631;131.7;240.861;42.4612;539.113;39.2381;10.0162;161.702;18.1872;12.8863;212.603;935.649;11.0684;14.384;986.476;147.66;234.759;191.145;22.9134;760.927;766.819;20.7941;206.982 4.11644;26.6888;5.72311E-12;5.02186;13.7308;37.7692;625.677;138.711;356.883;25.6719;3.35457;7.73944;443.137;6.82654;15.7729;9.42992;39.9158;78.9726;20.6424;334.248;18.9587;3.29405;50.9087;10.0176;9.13136;119.81;808.484;4.18343;4.89199;552.974;96.6023;129.148;113.564;11.4115;413.607;421.048;8.25355;118.025 94.078;262.273;5.72313E-12;80.1461;99.4885;148.485;1106.02;1554.21;1021.06;148.788;114.038;86.1211;2039.06;76.1794;157.407;25.7196;397.209;847.87;98.0534;1187.86;81.6965;37.7305;481.517;36.7271;19.3234;1510.69;1071.05;17.0564;58.2504;2230.86;285.773;694.216;510.267;50.1592;2639.93;2662.07;57.2115;1531.55 8 30 8 362282;259241;24314;24426;25315;312495;24296;29397 PCK1_9439;NR1D2_9358;NQO1_33055;GSTP1_8762;EPHX1_8567;CYP26B1_8418;CYP1A1_8415;CCL11_33230 206.9561 27.42705 361.416356952279 121.06107375 9.723759999999999 212.67100465893355 451.9432125 83.9088 794.1534687513877 529.244;29.1728;25.6813;14.7631;39.2381;18.1872;12.8863;986.476 356.883;3.35457;7.73944;9.42992;18.9587;10.0176;9.13136;552.974 1021.06;114.038;86.1211;25.7196;81.6965;36.7271;19.3234;2230.86 30 116669;360243;24832;25671;295703;25682;288583;25154;338475;81687;291234;362376;25283;81919;24367;309186;361921;64191;84032;24854;113902;114494;686019;24232;25612;29657;29221;81639;24646;170913 VWF_32396;TOP2A_10059;THY1_33010;SMAD1_32578;SERPING1_32597;PPARD_9536;PLOD3_9507;PGR_32824;NREP_9364;MMP9_32531;MKI67_9232;HERC6_8794;GCLC_8699;FUT1_8668;FGG_8639;FERMT3_32542;ECT2_8523;DHCR7_8466;COL3A1_8354;CLU_32773;CES1D_32914;CCNA2_8221;CASQ1_32992;C3_8175;ASNS_8091;ARNTL_8086;ARG1_33267;ALOX15_8036;ABCB1B_7939;ABCB1A_7938 230.7950000000002 112.90369999999999 290.9736201199913 137.3377920000002 38.8425 206.4951939644706 663.4866133333334 274.023 786.8256655921322 19.6764;86.3883;5.72311E-12;21.9973;32.3997;94.1074;882.629;283.618;61.543;728.316;21.9311;39.6865;131.7;240.861;42.4612;539.113;10.0162;161.702;212.603;935.649;11.0684;14.384;147.66;234.759;191.145;22.9134;760.927;766.819;20.7941;206.982 4.11644;26.6888;5.72311E-12;5.02186;13.7308;37.7692;625.677;138.711;25.6719;443.137;6.82654;15.7729;39.9158;78.9726;20.6424;334.248;3.29405;50.9087;119.81;808.484;4.18343;4.89199;96.6023;129.148;113.564;11.4115;413.607;421.048;8.25355;118.025 94.078;262.273;5.72313E-12;80.1461;99.4885;148.485;1106.02;1554.21;148.788;2039.06;76.1794;157.407;397.209;847.87;98.0534;1187.86;37.7305;481.517;1510.69;1071.05;17.0564;58.2504;285.773;694.216;510.267;50.1592;2639.93;2662.07;57.2115;1531.55 0 Exp 2,4(0.11);Exp 4,16(0.43);Exp 5,2(0.06);Hill,5(0.14);Linear,2(0.06);Poly 2,8(0.22);Power,1(0.03) 2.0908596437594205 92.42767822742462 1.5021449327468872 15.48720932006836 2.328331515708713 1.875340223312378 129.7727138510205 321.77985457003234 68.73225286172901 199.0899760856397 370.1751942261423 867.7271268264894 DOWN 0.21052631578947367 0.7894736842105263 0.0 GO:0035295 4 tube development 61 65 6 6 4 5 4 4 64 61 2418 0.97198 0.093345 0.093345 6.15 25671;288583;24296;84032 smad1;plod3;cyp1a1;col3a1 SMAD1_32578;PLOD3_9507;CYP1A1_8415;COL3A1_8354 282.5289 117.30015 12.8863 410.52552005291136 244.5614065286264 379.5119544763005 189.910055 64.47068 5.02186 295.33677346485723 163.0252679090292 271.5615749363843 679.044875 593.08305 19.3234 745.6213378960547 675.1083697782303 773.9916259322667 2.5 547.616 21.9973;882.629;12.8863;212.603 5.02186;625.677;9.13136;119.81 80.1461;1106.02;19.3234;1510.69 1 3 1 24296 CYP1A1_8415 12.8863 12.8863 9.13136 9.13136 19.3234 19.3234 12.8863 9.13136 19.3234 3 25671;288583;84032 SMAD1_32578;PLOD3_9507;COL3A1_8354 372.40976666666666 212.603 452.0236528828589 250.16962 119.81 330.22480766443516 898.9520333333334 1106.02 737.4088550942439 21.9973;882.629;212.603 5.02186;625.677;119.81 80.1461;1106.02;1510.69 0 Exp 4,2(0.5);Poly 2,2(0.5) 2.9188558220949736 20.50947916507721 1.6129854917526245 15.48720932006836 6.906701138594173 1.7046421766281128 -119.78610965185311 684.8439096518532 -99.5199829955601 479.3400929955601 -51.6640361381335 1409.7537861381336 DOWN 0.25 0.75 0.0 GO:0006954 5 inflammatory response 129 140 14 13 8 7 5 5 63 135 2344 0.83254 0.31769 0.42056 3.57 25671;312495;245920;29397;24232 smad1;cyp26b1;cxcl10;ccl11;c3 SMAD1_32578;CYP26B1_8418;CXCL10_8408;CCL11_33230;C3_8175 386.3895 234.759 18.1872 427.83902122786793 395.58003821143205 474.9410760244959 214.39269199999998 129.148 5.02186 241.4748585549774 220.6963028162262 266.9063044631213 999.44984 694.216 36.7271 1036.2362964227189 957.6867304548249 1100.5600582681411 21.9973;18.1872;670.528;986.476;234.759 5.02186;10.0176;374.802;552.974;129.148 80.1461;36.7271;1955.3;2230.86;694.216 2 3 2 312495;29397 CYP26B1_8418;CCL11_33230 502.3316 502.3316 684.6835766269847 281.49580000000003 281.49580000000003 383.9281523286356 1133.79355 1133.79355 1551.486252414505 18.1872;986.476 10.0176;552.974 36.7271;2230.86 3 25671;245920;24232 SMAD1_32578;CXCL10_8408;C3_8175 309.09476666666666 234.759 330.5939682829427 169.65728666666666 129.148 188.1889734131268 909.8873666666667 694.216 956.0000737297061 21.9973;670.528;234.759 5.02186;374.802;129.148 80.1461;1955.3;694.216 0 Exp 2,1(0.2);Exp 4,2(0.4);Poly 2,1(0.2);Power,1(0.2) 1.8225563584870528 9.165595293045044 1.5467612743377686 2.090334892272949 0.218043740628454 1.8538048267364502 11.372063122144652 761.4069368778553 2.73064615425821 426.0547378457418 91.14867857490208 1907.751001425098 DOWN 0.4 0.6 0.0 GO:0071345 6 cellular response to cytokine stimulus 172 189 15 15 8 10 7 7 61 182 2297 0.87283 0.23683 0.34503 3.7 362282;81687;24367;29397;29221;81639;24646 pck1;mmp9;fgg;ccl11;arg1;alox15;abcb1b PCK1_9439;MMP9_32531;FGG_8639;CCL11_33230;ARG1_33267;ALOX15_8036;ABCB1B_7939 547.8624714285714 728.316 20.7941 376.7983366381134 470.443045022539 414.8357870494018 316.64927857142857 413.607 8.25355 214.66841108778257 267.2405090886197 237.31434358547196 1535.463557142857 2039.06 57.2115 1135.9476157513632 1367.4823185927623 1230.9890048577201 529.244;728.316;42.4612;986.476;760.927;766.819;20.7941 356.883;443.137;20.6424;552.974;413.607;421.048;8.25355 1021.06;2039.06;98.0534;2230.86;2639.93;2662.07;57.2115 2 5 2 362282;29397 PCK1_9439;CCL11_33230 757.86 757.86 323.3118477754875 454.9285 454.9285 138.65727582965147 1625.96 1625.96 855.4577838794855 529.244;986.476 356.883;552.974 1021.06;2230.86 5 81687;24367;29221;81639;24646 MMP9_32531;FGG_8639;ARG1_33267;ALOX15_8036;ABCB1B_7939 463.86346000000003 728.316 394.92223108809407 261.33759 413.607 225.68236503564142 1499.26498 2039.06 1321.6961637524537 728.316;42.4612;760.927;766.819;20.7941 443.137;20.6424;413.607;421.048;8.25355 2039.06;98.0534;2639.93;2662.07;57.2115 0 Exp 2,2(0.29);Exp 4,1(0.15);Hill,1(0.15);Linear,2(0.29);Power,1(0.15) 2.2128120500654727 17.66865110397339 1.5021449327468872 6.191005229949951 1.6807112931467123 1.9814788103103638 268.7263573417425 826.9985855154001 157.62069414912568 475.6778629937314 693.9417869138952 2376.985327371819 DOWN 0.2857142857142857 0.7142857142857143 0.0 GO:0015711 6 organic anion transport 106 111 9 9 8 8 7 7 61 104 2375 0.9916 0.026606 0.026606 6.31 313089;294881;170551;89776;25682;24646;170913 slc7a13;slc7a12;slc5a6;slc22a7;ppard;abcb1b;abcb1a SLC7A13_32952;SLC7A12_32838;SLC5A6_9881;SLC22A7_9847;PPARD_9536;ABCB1B_7939;ABCB1A_7938 132.42277142857142 94.1074 20.7941 132.91645570435983 111.31262934058432 117.15391600834151 79.33917857142856 37.7692 8.25355 97.47270895311267 64.6815153753796 84.16614115939835 417.15978571428565 161.307 57.2115 530.9830146252215 395.67289634390374 547.108224823053 4.5 163.52949999999998 397.931;37.9163;120.077;49.1516;94.1074;20.7941;206.982 280.111;15.3983;82.2177;13.5995;37.7692;8.25355;118.025 668.129;132.15;221.286;161.307;148.485;57.2115;1531.55 0 7 0 7 313089;294881;170551;89776;25682;24646;170913 SLC7A13_32952;SLC7A12_32838;SLC5A6_9881;SLC22A7_9847;PPARD_9536;ABCB1B_7939;ABCB1A_7938 132.42277142857142 94.1074 132.91645570435983 79.33917857142856 37.7692 97.47270895311267 417.15978571428565 161.307 530.9830146252215 397.931;37.9163;120.077;49.1516;94.1074;20.7941;206.982 280.111;15.3983;82.2177;13.5995;37.7692;8.25355;118.025 668.129;132.15;221.286;161.307;148.485;57.2115;1531.55 0 Exp 2,1(0.15);Exp 4,1(0.15);Exp 5,1(0.15);Hill,2(0.29);Poly 2,2(0.29) 2.2548521617153634 17.719918370246887 1.517665982246399 6.191005229949951 1.6327289041002437 1.913203477859497 33.956883084848215 230.88865977229463 7.130385269828338 151.5479718730288 23.802063726927486 810.5175077016439 DOWN 0.0 1.0 0.0 GO:0010038 5 response to metal ion 201 215 19 18 14 13 11 11 57 204 2275 0.99002 0.024849 0.041891 5.12 24314;81687;25283;24367;361921;24296;24854;24232;29221;81639;170913 nqo1;mmp9;gclc;fgg;ect2;cyp1a1;clu;c3;arg1;alox15;abcb1a NQO1_33055;MMP9_32531;GCLC_8699;FGG_8639;ECT2_8523;CYP1A1_8415;CLU_32773;C3_8175;ARG1_33267;ALOX15_8036;ABCB1A_7938 350.56336363636365 206.982 10.0162 365.9358173304173 321.63337408964037 354.58512496030903 219.47018636363637 118.025 3.29405 264.82310620098536 194.17621656838523 247.15155921650904 1025.1194 694.216 19.3234 1039.4891915480227 991.9275236549133 1040.56646982453 9.5 851.2339999999999 25.6813;728.316;131.7;42.4612;10.0162;12.8863;935.649;234.759;760.927;766.819;206.982 7.73944;443.137;39.9158;20.6424;3.29405;9.13136;808.484;129.148;413.607;421.048;118.025 86.1211;2039.06;397.209;98.0534;37.7305;19.3234;1071.05;694.216;2639.93;2662.07;1531.55 2 9 2 24314;24296 NQO1_33055;CYP1A1_8415 19.2838 19.2838 9.047431265281876 8.435400000000001 8.435400000000001 0.9842360708691725 52.72225 52.72225 47.23310663766464 25.6813;12.8863 7.73944;9.13136 86.1211;19.3234 9 81687;25283;24367;361921;24854;24232;29221;81639;170913 MMP9_32531;GCLC_8699;FGG_8639;ECT2_8523;CLU_32773;C3_8175;ARG1_33267;ALOX15_8036;ABCB1A_7938 424.1810444444444 234.759 365.84491303113373 266.3668055555556 129.148 272.13204720387176 1241.2076555555554 1071.05 1030.2783109875788 728.316;131.7;42.4612;10.0162;935.649;234.759;760.927;766.819;206.982 443.137;39.9158;20.6424;3.29405;808.484;129.148;413.607;421.048;118.025 2039.06;397.209;98.0534;37.7305;1071.05;694.216;2639.93;2662.07;1531.55 0 Exp 2,2(0.19);Exp 4,3(0.28);Hill,2(0.19);Linear,1(0.1);Poly 2,3(0.28) 2.2209269002730423 34.14436233043671 1.5021449327468872 15.48720932006836 4.125917765039919 1.8874764442443848 134.30911502394784 566.8176122487794 62.969731544835156 375.97064118243753 410.8205437173143 1639.418256282686 DOWN 0.18181818181818182 0.8181818181818182 0.0 GO:0034762 5 regulation of transmembrane transport 122 128 10 9 6 8 6 6 62 122 2357 0.94817 0.12358 0.15218 4.69 24832;81687;245920;686019;24232;170913 thy1;mmp9;cxcl10;casq1;c3;abcb1a THY1_33010;MMP9_32531;CXCL10_8408;CASQ1_32992;C3_8175;ABCB1A_7938 331.37416666666763 220.8705 5.72311E-12 296.9699569454222 307.6646444564344 285.31956101067664 193.61905000000095 123.5865 5.72311E-12 174.27451433291833 184.86751695103925 171.12780521488602 1084.3165000000008 1112.883 5.72313E-12 875.8718633740314 1035.9488169341791 869.0177371798623 5.72311E-12;728.316;670.528;147.66;234.759;206.982 5.72311E-12;443.137;374.802;96.6023;129.148;118.025 5.72313E-12;2039.06;1955.3;285.773;694.216;1531.55 0 6 0 6 24832;81687;245920;686019;24232;170913 THY1_33010;MMP9_32531;CXCL10_8408;CASQ1_32992;C3_8175;ABCB1A_7938 331.37416666666763 220.8705 296.9699569454222 193.61905000000095 123.5865 174.27451433291833 1084.3165000000008 1112.883 875.8718633740314 5.72311E-12;728.316;670.528;147.66;234.759;206.982 5.72311E-12;443.137;374.802;96.6023;129.148;118.025 5.72313E-12;2039.06;1955.3;285.773;694.216;1531.55 0 Exp 2,1(0.17);Hill,1(0.17);Linear,1(0.17);Poly 2,3(0.5) 1.9072729562130735 11.529659748077393 1.5467612743377686 2.327066659927368 0.2572594572978877 1.875340223312378 93.74871127216016 568.9996220611752 54.17039580624652 333.0677041937554 383.4730458598218 1785.1599541401797 DOWN 0.0 1.0 0.0 GO:0051050 5 positive regulation of transport 286 308 21 20 14 13 11 11 57 297 2182 0.88849 0.19168 0.34264 3.57 688621;24832;25682;24367;361921;245920;24854;113902;686019;24232;170913 tslp;thy1;ppard;fgg;ect2;cxcl10;clu;ces1d;casq1;c3;abcb1a TSLP_32811;THY1_33010;PPARD_9536;FGG_8639;ECT2_8523;CXCL10_8408;CLU_32773;CES1D_32914;CASQ1_32992;C3_8175;ABCB1A_7938 245.26420000000053 147.66 5.72311E-12 302.12360082889205 207.31154887047504 261.0729436190569 167.01367090909142 96.6023 5.72311E-12 242.64159008233202 144.31194640801374 218.85257253235335 581.7863000000006 285.773 5.72313E-12 671.105769216237 504.30384999134856 579.8858066535861 344.675;5.72311E-12;94.1074;42.4612;10.0162;670.528;935.649;11.0684;147.66;234.759;206.982 244.2;5.72311E-12;37.7692;20.6424;3.29405;374.802;808.484;4.18343;96.6023;129.148;118.025 560.435;5.72313E-12;148.485;98.0534;37.7305;1955.3;1071.05;17.0564;285.773;694.216;1531.55 0 11 0 11 688621;24832;25682;24367;361921;245920;24854;113902;686019;24232;170913 TSLP_32811;THY1_33010;PPARD_9536;FGG_8639;ECT2_8523;CXCL10_8408;CLU_32773;CES1D_32914;CASQ1_32992;C3_8175;ABCB1A_7938 245.26420000000053 147.66 302.12360082889205 167.01367090909142 96.6023 242.64159008233202 581.7863000000006 285.773 671.105769216237 344.675;5.72311E-12;94.1074;42.4612;10.0162;670.528;935.649;11.0684;147.66;234.759;206.982 244.2;5.72311E-12;37.7692;20.6424;3.29405;374.802;808.484;4.18343;96.6023;129.148;118.025 560.435;5.72313E-12;148.485;98.0534;37.7305;1955.3;1071.05;17.0564;285.773;694.216;1531.55 0 Exp 2,2(0.19);Exp 4,2(0.19);Exp 5,2(0.19);Hill,1(0.1);Poly 2,4(0.37) 1.8548941755056085 20.738376259803772 1.5467612743377686 2.8176381587982178 0.38227118987678116 1.8538048267364502 66.72056149539469 423.8078385046063 23.621654439718895 310.40568737846394 185.1881344526479 978.3844655473532 DOWN 0.0 1.0 0.0 GO:0006469 8 negative regulation of protein kinase activity 71 76 7 6 5 2 2 2 66 74 2405 0.66873 0.60962 1.0 2.63 24832;24426 thy1;gstp1 THY1_33010;GSTP1_8762 7.3815500000028615 7.3815500000028615 5.72311E-12 10.439088121331073 7.158549252367917 10.434323271684848 4.714960000002861 4.714960000002861 5.72311E-12 6.667960378042601 4.5725184253920235 6.66491683359896 12.859800000002862 12.859800000002862 5.72313E-12 18.18650356940148 12.471298260607162 18.17820246550318 5.72311E-12;14.7631 5.72311E-12;9.42992 5.72313E-12;25.7196 1 1 1 24426 GSTP1_8762 14.7631 14.7631 9.42992 9.42992 25.7196 25.7196 14.7631 9.42992 25.7196 1 24832 THY1_33010 5.72311E-12 5.72311E-12 5.72311E-12 5.72311E-12 5.72313E-12 5.72313E-12 5.72311E-12 5.72311E-12 5.72313E-12 0 Exp 4,1(0.5);Hill,1(0.5) 2.5639300962095986 5.3913938999176025 1.863204002380371 3.5281898975372314 1.17732281704537 2.6956969499588013 -7.086287999991529 21.84938799999725 -4.526361599991528 13.95628159999725 -12.345407999991528 38.06500799999725 CONFLICT 0.5 0.5 0.0 GO:0006629 4 lipid metabolic process 289 320 19 19 15 15 13 13 55 307 2172 0.96067 0.076544 0.13417 4.06 286989;25682;25154;362282;24426;25315;64191;312495;24296;113902;24232;81639;252898 ugt2b7;ppard;pgr;pck1;gstp1;ephx1;dhcr7;cyp26b1;cyp1a1;ces1d;c3;alox15;acox2 UGT2B7_33032;PPARD_9536;PGR_32824;PCK1_9439;GSTP1_8762;EPHX1_8567;DHCR7_8466;CYP26B1_8418;CYP1A1_8415;CES1D_32914;C3_8175;ALOX15_8036;ACOX2_32902 226.4967769230769 94.1074 11.0684 278.0753170870533 200.59873575598135 269.2246471003163 125.65375461538461 37.7692 4.18343 165.1478824059788 104.01979231806133 155.75613691901225 702.6842307692308 148.485 17.0564 918.1506173005534 639.8931346845117 918.8028845828389 34.7126;94.1074;283.618;529.244;14.7631;39.2381;161.702;18.1872;12.8863;11.0684;234.759;766.819;743.353 14.7729;37.7692;138.711;356.883;9.42992;18.9587;50.9087;10.0176;9.13136;4.18343;129.148;421.048;432.537 105.024;148.485;1554.21;1021.06;25.7196;81.6965;481.517;36.7271;19.3234;17.0564;694.216;2662.07;2287.79 6 7 6 286989;362282;24426;25315;312495;24296 UGT2B7_33032;PCK1_9439;GSTP1_8762;EPHX1_8567;CYP26B1_8418;CYP1A1_8415 108.17188333333335 26.4499 206.5679775067899 69.86558 12.39525 140.66172783888132 214.92510000000001 59.2118 396.35712737739937 34.7126;529.244;14.7631;39.2381;18.1872;12.8863 14.7729;356.883;9.42992;18.9587;10.0176;9.13136 105.024;1021.06;25.7196;81.6965;36.7271;19.3234 7 25682;25154;64191;113902;24232;81639;252898 PPARD_9536;PGR_32824;DHCR7_8466;CES1D_32914;C3_8175;ALOX15_8036;ACOX2_32902 327.91811428571424 234.759 305.1093357731041 173.47218999999998 129.148 179.66502463618332 1120.7634857142857 694.216 1055.1086949281505 94.1074;283.618;161.702;11.0684;234.759;766.819;743.353 37.7692;138.711;50.9087;4.18343;129.148;421.048;432.537 148.485;1554.21;481.517;17.0564;694.216;2662.07;2287.79 0 Exp 2,2(0.16);Exp 4,6(0.47);Exp 5,2(0.16);Linear,1(0.08);Poly 2,2(0.16) 2.3571440137182975 42.176515340805054 1.5021449327468872 15.48720932006836 3.881505163776892 1.7927976846694946 75.33331262856726 377.66024121758664 35.878343094142664 215.42916613662658 203.57186973991713 1201.7965917985443 CONFLICT 0.46153846153846156 0.5384615384615384 0.0 GO:0022603 5 regulation of anatomical structure morphogenesis 271 280 19 19 10 14 8 8 60 272 2207 0.67106 0.47655 0.84349 2.86 684352;24832;25671;81687;81919;245920;29397;24232 twf2;thy1;smad1;mmp9;fut1;cxcl10;ccl11;c3 TWF2_10109;THY1_33010;SMAD1_32578;MMP9_32531;FUT1_8668;CXCL10_8408;CCL11_33230;C3_8175 377.66703750000073 237.81 5.72311E-12 367.4024141210978 437.00874147464015 365.8163496924614 209.34897000000075 109.94215 5.72311E-12 214.87053490709232 238.88944080265256 222.2085354691365 1018.3271375000008 771.043 5.72313E-12 922.6144007713426 1183.8127705233014 881.7386006174436 138.399;5.72311E-12;21.9973;728.316;240.861;670.528;986.476;234.759 90.7363;5.72311E-12;5.02186;443.137;78.9726;374.802;552.974;129.148 299.165;5.72313E-12;80.1461;2039.06;847.87;1955.3;2230.86;694.216 1 7 1 29397 CCL11_33230 986.476 986.476 552.974 552.974 2230.86 2230.86 986.476 552.974 2230.86 7 684352;24832;25671;81687;81919;245920;24232 TWF2_10109;THY1_33010;SMAD1_32578;MMP9_32531;FUT1_8668;CXCL10_8408;C3_8175 290.69432857142937 234.759 294.75798541773526 160.25968000000083 90.7363 177.12470061484507 845.108157142858 694.216 844.4181111708846 138.399;5.72311E-12;21.9973;728.316;240.861;670.528;234.759 90.7363;5.72311E-12;5.02186;443.137;78.9726;374.802;129.148 299.165;5.72313E-12;80.1461;2039.06;847.87;1955.3;694.216 0 Exp 2,2(0.25);Exp 4,1(0.13);Hill,1(0.13);Linear,1(0.13);Poly 2,2(0.25);Power,1(0.13) 1.9146672234195936 15.521478176116943 1.5467612743377686 2.737008571624756 0.35843540201640584 1.8585044145584106 123.07015381965101 632.2639211803503 60.451285936214646 358.24665406378676 378.987976278337 1657.6662987216646 DOWN 0.125 0.875 0.0 GO:0042493 4 response to drug 436 472 38 37 24 26 18 18 50 454 2025 0.96439 0.064979 0.1115 3.81 360243;25671;25154;362282;24314;316351;81687;24426;25283;361921;24296;170945;114494;24232;25612;29221;24646;170913 top2a;smad1;pgr;pck1;nqo1;npas2;mmp9;gstp1;gclc;ect2;cyp1a1;chrna2;ccna2;c3;asns;arg1;abcb1b;abcb1a TOP2A_10059;SMAD1_32578;PGR_32824;PCK1_9439;NQO1_33055;NPAS2_9350;MMP9_32531;GSTP1_8762;GCLC_8699;ECT2_8523;CYP1A1_8415;CHRNA2_32401;CCNA2_8221;C3_8175;ASNS_8091;ARG1_33267;ABCB1B_7939;ABCB1A_7938 192.12046666666666 109.04415 10.0162 241.84854751796507 177.39820662268565 236.861248046517 107.81890388888888 33.3023 3.29405 145.82352576943578 96.96213270769293 140.81547057898192 637.3445555555556 329.741 19.3234 796.4796505632845 600.3998109159425 793.0720951068138 86.3883;21.9973;283.618;529.244;25.6813;21.0878;728.316;14.7631;131.7;10.0162;12.8863;163.479;14.384;234.759;191.145;760.927;20.7941;206.982 26.6888;5.02186;138.711;356.883;7.73944;11.3305;443.137;9.42992;39.9158;3.29405;9.13136;101.968;4.89199;129.148;113.564;413.607;8.25355;118.025 262.273;80.1461;1554.21;1021.06;86.1211;43.5624;2039.06;25.7196;397.209;37.7305;19.3234;414.362;58.2504;694.216;510.267;2639.93;57.2115;1531.55 4 14 4 362282;24314;24426;24296 PCK1_9439;NQO1_33055;GSTP1_8762;CYP1A1_8415 145.643675 20.2222 255.79576898049447 95.79593 9.28064 174.05960562300683 288.056025 55.92035 489.59512692350455 529.244;25.6813;14.7631;12.8863 356.883;7.73944;9.42992;9.13136 1021.06;86.1211;25.7196;19.3234 14 360243;25671;25154;316351;81687;25283;361921;170945;114494;24232;25612;29221;24646;170913 TOP2A_10059;SMAD1_32578;PGR_32824;NPAS2_9350;MMP9_32531;GCLC_8699;ECT2_8523;CHRNA2_32401;CCNA2_8221;C3_8175;ASNS_8091;ARG1_33267;ABCB1B_7939;ABCB1A_7938 205.39955 147.5895 246.0360772831489 111.25403928571428 70.9419 144.07873452411977 737.1412785714285 405.7855 852.0520792933575 86.3883;21.9973;283.618;21.0878;728.316;131.7;10.0162;163.479;14.384;234.759;191.145;760.927;20.7941;206.982 26.6888;5.02186;138.711;11.3305;443.137;39.9158;3.29405;101.968;4.89199;129.148;113.564;413.607;8.25355;118.025 262.273;80.1461;1554.21;43.5624;2039.06;397.209;37.7305;414.362;58.2504;694.216;510.267;2639.93;57.2115;1531.55 0 Exp 2,1(0.06);Exp 4,7(0.39);Hill,3(0.17);Linear,2(0.12);Poly 2,5(0.28) 2.2852659641840414 53.10974037647247 1.513624906539917 15.48720932006836 3.325596922409733 1.8464288115501404 80.39213799288754 303.8487953404458 40.45187198919736 175.18593578858042 269.38972972183393 1005.2993813892774 DOWN 0.2222222222222222 0.7777777777777778 0.0 GO:1903047 4 mitotic cell cycle process 136 146 15 15 12 9 9 9 59 137 2342 0.99538 0.014073 0.014073 6.16 315852;360243;295661;316273;293502;361921;306575;114494;170913 ttk;top2a;spc25;mcm3;kif22;ect2;ckap2;ccna2;abcb1a TTK_32727;TOP2A_10059;SPC25_9925;MCM3_9207;KIF22_8963;ECT2_8523;CKAP2_8324;CCNA2_8221;ABCB1A_7938 148.6481222222222 35.8903 10.0162 233.7133748488027 105.33499150975517 191.88457605889764 82.87796444444444 15.2683 3.12114 144.16174445612333 55.54285163352514 118.17554694920845 531.7946888888889 124.006 37.7305 757.829320098199 414.6512774796554 675.9341738622389 6.5 202.1275 737.351;86.3883;35.8903;197.273;17.3097;10.0162;32.2386;14.384;206.982 446.625;26.6888;11.5744;116.413;3.12114;3.29405;15.2683;4.89199;118.025 2108.09;262.273;124.006;496.915;90.6321;37.7305;76.7052;58.2504;1531.55 0 9 0 9 315852;360243;295661;316273;293502;361921;306575;114494;170913 TTK_32727;TOP2A_10059;SPC25_9925;MCM3_9207;KIF22_8963;ECT2_8523;CKAP2_8324;CCNA2_8221;ABCB1A_7938 148.6481222222222 35.8903 233.7133748488027 82.87796444444444 15.2683 144.16174445612333 531.7946888888889 124.006 757.829320098199 737.351;86.3883;35.8903;197.273;17.3097;10.0162;32.2386;14.384;206.982 446.625;26.6888;11.5744;116.413;3.12114;3.29405;15.2683;4.89199;118.025 2108.09;262.273;124.006;496.915;90.6321;37.7305;76.7052;58.2504;1531.55 0 Exp 4,5(0.56);Hill,1(0.12);Linear,1(0.12);Poly 2,2(0.23) 1.7355659800381646 15.707352995872498 1.5111545324325562 2.0582168102264404 0.1970665134705805 1.6358354091644287 -4.044616012328845 301.3408604567733 -11.307708600222782 177.06363748911167 36.67953309139881 1026.909844686379 DOWN 0.0 1.0 0.0 GO:0001775 3 cell activation 161 172 8 8 5 4 4 4 64 168 2311 0.50946 0.68558 1.0 2.33 116669;24832;245920;24854 vwf;thy1;cxcl10;clu VWF_32396;THY1_33010;CXCL10_8408;CLU_32773 406.46335000000147 345.10220000000004 5.72311E-12 470.6676786329059 266.9220689181657 454.79866994314307 296.85061000000144 189.45922000000002 5.72311E-12 383.6920309783103 207.7954346522284 383.37415121156556 780.1070000000013 582.564 5.72313E-12 921.0373023187843 436.52199575750916 699.2729942894309 19.6764;5.72311E-12;670.528;935.649 4.11644;5.72311E-12;374.802;808.484 94.078;5.72313E-12;1955.3;1071.05 0 4 0 4 116669;24832;245920;24854 VWF_32396;THY1_33010;CXCL10_8408;CLU_32773 406.46335000000147 345.10220000000004 470.6676786329059 296.85061000000144 189.45922000000002 383.6920309783103 780.1070000000013 582.564 921.0373023187843 19.6764;5.72311E-12;670.528;935.649 4.11644;5.72311E-12;374.802;808.484 94.078;5.72313E-12;1955.3;1071.05 0 Exp 2,1(0.25);Hill,2(0.5);Poly 2,1(0.25) 1.830658561107273 7.36315643787384 1.5548590421676636 2.0912885665893555 0.2199831946041591 1.8585044145584106 -54.79097506024635 867.7176750602493 -79.16758035874267 672.8688003587456 -122.50955627240717 1682.72355627241 DOWN 0.0 1.0 0.0 GO:0015893 5 drug transport 30 33 4 4 3 2 2 2 66 31 2448 0.94386 0.21961 0.21961 6.06 170551;170913 slc5a6;abcb1a SLC5A6_9881;ABCB1A_7938 163.52949999999998 163.52949999999998 120.077 61.451114819017064 163.18945435016113 61.44923311492215 100.12135 100.12135 82.2177 25.319584645981017 99.98124164492866 25.318809331062077 876.418 876.418 221.286 926.4965595446102 871.2911422433635 926.4681891501114 0.5 163.52949999999998 120.077;206.982 82.2177;118.025 221.286;1531.55 0 2 0 2 170551;170913 SLC5A6_9881;ABCB1A_7938 163.52949999999998 163.52949999999998 61.451114819017064 100.12135 100.12135 25.319584645981017 876.418 876.418 926.4965595446102 120.077;206.982 82.2177;118.025 221.286;1531.55 0 Poly 2,2(1) 1.6925007508775571 3.4051424264907837 1.517665982246399 1.8874764442443848 0.26149548543250584 1.7025712132453918 78.36259999999999 248.69639999999998 65.03019599999999 135.21250400000002 -407.6407200000001 2160.4767199999997 DOWN 0.0 1.0 0.0 GO:0019216 6 regulation of lipid metabolic process 132 142 10 9 7 8 6 6 62 136 2343 0.91864 0.17536 0.27367 4.23 25682;363131;259241;64191;113902;24232 ppard;pik3r4;nr1d2;dhcr7;ces1d;c3 PPARD_9536;PIK3R4_9484;NR1D2_9358;DHCR7_8466;CES1D_32914;C3_8175 247.73960000000002 127.90469999999999 11.0684 356.66917649082035 184.19213257853067 256.25271770816926 160.09865 44.33895 3.35457 285.4809674664301 97.8073313152294 206.26938743345215 457.3804 315.001 17.0564 480.707923061395 408.7228569251724 362.09660065123694 94.1074;955.628;29.1728;161.702;11.0684;234.759 37.7692;735.228;3.35457;50.9087;4.18343;129.148 148.485;1288.97;114.038;481.517;17.0564;694.216 1 5 1 259241 NR1D2_9358 29.1728 29.1728 3.35457 3.35457 114.038 114.038 29.1728 3.35457 114.038 5 25682;363131;64191;113902;24232 PPARD_9536;PIK3R4_9484;DHCR7_8466;CES1D_32914;C3_8175 291.45295999999996 161.702 380.37441160602276 191.447466 50.9087 307.4144051560487 526.04888 481.517 503.47287218495893 94.1074;955.628;161.702;11.0684;234.759 37.7692;735.228;50.9087;4.18343;129.148 148.485;1288.97;481.517;17.0564;694.216 0 Exp 4,2(0.34);Exp 5,2(0.34);Poly 2,2(0.34) 1.7494772728265242 10.589669346809387 1.5018656253814697 2.1823768615722656 0.2612039525384446 1.709883213043213 -37.65517986452136 533.1343798645214 -68.33369917915408 388.53099917915404 72.73395190759254 842.0268480924075 DOWN 0.16666666666666666 0.8333333333333334 0.0 GO:0051188 5 cofactor biosynthetic process 48 53 4 4 4 3 3 3 65 50 2429 0.94893 0.16659 0.16659 5.66 156275;25283;24296 ggt7;gclc;cyp1a1 GGT7_33026;GCLC_8699;CYP1A1_8415 84.73176666666666 109.609 12.8863 63.19281114702314 101.01922474856778 57.42882213448953 26.126920000000002 29.3336 9.13136 15.640733166805179 30.81756333290897 14.836706556659673 254.20179999999996 346.073 19.3234 205.01126728528848 304.1515098917887 183.93299265775332 1.5 120.65449999999998 109.609;131.7;12.8863 29.3336;39.9158;9.13136 346.073;397.209;19.3234 1 2 1 24296 CYP1A1_8415 12.8863 12.8863 9.13136 9.13136 19.3234 19.3234 12.8863 9.13136 19.3234 2 156275;25283 GGT7_33026;GCLC_8699 120.65449999999998 120.65449999999998 15.620695903192185 34.6247 34.6247 7.482745379872284 371.64099999999996 371.64099999999996 36.15861236275655 109.609;131.7 29.3336;39.9158 346.073;397.209 0 Exp 4,2(0.67);Hill,1(0.34) 3.8940543318875673 19.39268434047699 1.930785894393921 15.48720932006836 7.814161776166708 1.9746891260147095 13.222369074563986 156.24116425876934 8.427764251810952 43.82607574818904 22.209711706027434 486.1938882939726 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0055082 5 cellular chemical homeostasis 190 202 16 15 7 8 5 5 63 197 2282 0.54381 0.6378 1.0 2.48 24832;362282;25283;245920;686019 thy1;pck1;gclc;cxcl10;casq1 THY1_33010;PCK1_9439;GCLC_8699;CXCL10_8408;CASQ1_32992 295.8264000000012 147.66 5.72311E-12 287.78858613363934 171.51026116090208 181.2011023392979 173.64062000000115 96.6023 5.72311E-12 178.89379934615263 92.23623795544097 114.61086537504862 731.8684000000012 397.209 5.72313E-12 778.9489771829076 422.30781673507073 488.1582285480284 5.72311E-12;529.244;131.7;670.528;147.66 5.72311E-12;356.883;39.9158;374.802;96.6023 5.72313E-12;1021.06;397.209;1955.3;285.773 1 4 1 362282 PCK1_9439 529.244 529.244 356.883 356.883 1021.06 1021.06 529.244 356.883 1021.06 4 24832;25283;245920;686019 THY1_33010;GCLC_8699;CXCL10_8408;CASQ1_32992 237.47200000000143 139.68 296.18933204286594 127.83002500000143 68.25905 169.35146244120645 659.5705000000014 341.491 879.8686093822934 5.72311E-12;131.7;670.528;147.66 5.72311E-12;39.9158;374.802;96.6023 5.72313E-12;397.209;1955.3;285.773 0 Exp 2,1(0.2);Hill,2(0.4);Linear,1(0.2);Poly 2,1(0.2) 1.9123515938736428 9.6301771402359 1.611412525177002 2.327066659927368 0.2604543386549491 1.863204002380371 43.568582036599764 548.0842179634026 16.833291132248945 330.4479488677533 49.08951731791501 1414.6472826820873 DOWN 0.2 0.8 0.0 GO:0048565 5 digestive tract development 26 28 3 3 2 3 2 2 66 26 2453 0.96298 0.17069 0.17069 7.14 24296;84032 cyp1a1;col3a1 CYP1A1_8415;COL3A1_8354 112.74465000000001 112.74465000000001 12.8863 141.22103288619934 99.18197550194026 139.91242922043904 64.47068 64.47068 9.13136 78.26161687650468 56.95454154884426 77.53641726112265 765.0067 765.0067 19.3234 1054.5554360951255 663.7286408638435 1044.783555227113 0.5 112.74465000000001 12.8863;212.603 9.13136;119.81 19.3234;1510.69 1 1 1 24296 CYP1A1_8415 12.8863 12.8863 9.13136 9.13136 19.3234 19.3234 12.8863 9.13136 19.3234 1 84032 COL3A1_8354 212.603 212.603 119.81 119.81 1510.69 1510.69 212.603 119.81 1510.69 0 Exp 4,1(0.5);Poly 2,1(0.5) 4.998064019298502 17.100194811820984 1.6129854917526245 15.48720932006836 9.810557752702037 8.550097405910492 -82.97771600000002 308.46701600000006 -43.99438719999999 172.93574719999998 -696.532568 2226.545968 CONFLICT 0.5 0.5 0.0 GO:0032101 5 regulation of response to external stimulus 254 266 21 20 12 14 10 10 58 256 2223 0.90891 0.16587 0.22936 3.76 688621;295703;25682;259241;24426;24367;245920;24232;29221;81639 tslp;serping1;ppard;nr1d2;gstp1;fgg;cxcl10;c3;arg1;alox15 TSLP_32811;SERPING1_32597;PPARD_9536;NR1D2_9358;GSTP1_8762;FGG_8639;CXCL10_8408;C3_8175;ARG1_33267;ALOX15_8036 299.06122 164.4332 14.7631 317.7950922079013 297.73637281410026 319.8256171575385 166.773189 83.45859999999999 3.35457 179.24220755255973 168.1355955307848 180.53607408309892 899.7735499999999 354.46 25.7196 1087.0127465398998 892.2649963510777 1124.9169931474928 344.675;32.3997;94.1074;29.1728;14.7631;42.4612;670.528;234.759;760.927;766.819 244.2;13.7308;37.7692;3.35457;9.42992;20.6424;374.802;129.148;413.607;421.048 560.435;99.4885;148.485;114.038;25.7196;98.0534;1955.3;694.216;2639.93;2662.07 2 8 2 259241;24426 NR1D2_9358;GSTP1_8762 21.96795 21.96795 10.18919658486379 6.392244999999999 6.392244999999999 4.295921183081692 69.8788 69.8788 62.45053954354597 29.1728;14.7631 3.35457;9.42992 114.038;25.7196 8 688621;295703;25682;24367;245920;24232;29221;81639 TSLP_32811;SERPING1_32597;PPARD_9536;FGG_8639;CXCL10_8408;C3_8175;ARG1_33267;ALOX15_8036 368.3345375 289.717 320.0196344997731 206.868425 186.67399999999998 179.21509334563592 1107.2472375 627.3254999999999 1128.1246822035964 344.675;32.3997;94.1074;42.4612;670.528;234.759;760.927;766.819 244.2;13.7308;37.7692;20.6424;374.802;129.148;413.607;421.048 560.435;99.4885;148.485;98.0534;1955.3;694.216;2639.93;2662.07 0 Exp 2,4(0.4);Exp 4,4(0.4);Exp 5,1(0.1);Poly 2,1(0.1) 1.9498737965889856 20.287619709968567 1.5021449327468872 3.5281898975372314 0.660123303744057 1.7860609889030457 102.08978116236153 496.03265883763845 55.6777177742662 277.86866022573383 226.03606955852592 1573.5110304414738 DOWN 0.2 0.8 0.0 GO:0009653 3 anatomical structure morphogenesis 282 299 18 18 10 10 7 7 61 292 2187 0.44497 0.70302 0.8494 2.34 288583;309186;361921;312495;84032;24854;29397 plod3;fermt3;ect2;cyp26b1;col3a1;clu;ccl11 PLOD3_9507;FERMT3_32542;ECT2_8523;CYP26B1_8418;COL3A1_8354;CLU_32773;CCL11_33230 512.0962000000001 539.113 10.0162 433.6250753668042 426.8549019205707 457.77917665992544 350.64352142857143 334.248 3.29405 320.52809083899854 288.20538981411624 328.2572190428871 1025.8482285714288 1106.02 36.7271 782.7920852374841 861.3717076891419 883.4528563416641 882.629;539.113;10.0162;18.1872;212.603;935.649;986.476 625.677;334.248;3.29405;10.0176;119.81;808.484;552.974 1106.02;1187.86;37.7305;36.7271;1510.69;1071.05;2230.86 2 5 2 312495;29397 CYP26B1_8418;CCL11_33230 502.3316 502.3316 684.6835766269847 281.49580000000003 281.49580000000003 383.9281523286356 1133.79355 1133.79355 1551.486252414505 18.1872;986.476 10.0176;552.974 36.7271;2230.86 5 288583;309186;361921;84032;24854 PLOD3_9507;FERMT3_32542;ECT2_8523;COL3A1_8354;CLU_32773 516.0020400000001 539.113 405.93277247027976 378.30261 334.248 337.50584264955404 982.6701 1106.02 556.0676582171002 882.629;539.113;10.0162;212.603;935.649 625.677;334.248;3.29405;119.81;808.484 1106.02;1187.86;37.7305;1510.69;1071.05 0 Exp 2,1(0.15);Exp 4,2(0.29);Poly 2,3(0.43);Power,1(0.15) 1.7421591789190134 12.26193654537201 1.5548590421676636 2.090334892272949 0.20280042033941081 1.6703740358352661 190.86224873458286 833.330151265417 113.19298878888458 588.0940540682583 445.94773654517223 1605.7487205976854 DOWN 0.2857142857142857 0.7142857142857143 0.0 GO:0052695 9 cellular glucuronidation 3 10 1 1 1 1 1 1 67 9 2470 0.97247 0.23746 0.23746 10.0 286989 ugt2b7 UGT2B7_33032 34.7126 34.7126 34.7126 34.7126 14.7729 14.7729 14.7729 14.7729 105.024 105.024 105.024 105.024 0.0 34.7126 0.0 34.7126 34.7126 14.7729 105.024 1 0 1 286989 UGT2B7_33032 34.7126 34.7126 14.7729 14.7729 105.024 105.024 34.7126 14.7729 105.024 0 0 Exp 4,1(1) 5.9308123588562 5.930812358856201 5.930812358856201 5.930812358856201 0.0 5.930812358856201 34.7126 34.7126 14.7729 14.7729 105.024 105.024 UP 1.0 0.0 0.0 GO:0031103 7 axon regeneration 17 18 3 3 1 2 1 1 67 17 2462 0.91834 0.38661 0.38661 5.56 338475 nrep NREP_9364 61.543 61.543 61.543 61.543 25.6719 25.6719 25.6719 25.6719 148.788 148.788 148.788 148.78800000000004 0.0 61.543 61.543 25.6719 148.788 0 1 0 1 338475 NREP_9364 61.543 61.543 25.6719 25.6719 148.788 148.788 61.543 25.6719 148.788 0 Exp 4,1(1) 1.7863717079162598 1.7863717079162598 1.7863717079162598 1.7863717079162598 0.0 1.7863717079162598 61.543 61.543 25.6719 25.6719 148.788 148.788 DOWN 0.0 1.0 0.0 GO:0006281 6 DNA repair 69 74 6 6 6 5 5 5 63 69 2410 0.98712 0.045495 0.045495 6.76 299112;300795;313108;316273;293502 pole2;pclaf;mms22l;mcm3;kif22 POLE2_9520;NS5ATP9_9367;MMS22L_33129;MCM3_9207;KIF22_8963 126.6903400543196 126.653 2.71598E-7 122.87719885387028 77.62967560575918 95.98636434447594 70.5272280543196 85.587 2.71598E-7 66.66537405724497 45.59309251368823 56.8604181909441 297.3054200543198 240.486 2.71599E-7 275.96829303338103 178.6996416660098 204.91066420221736 2.5 161.963 2.71598E-7;292.216;126.653;197.273;17.3097 2.71598E-7;147.515;85.587;116.413;3.12114 2.71599E-7;658.494;240.486;496.915;90.6321 0 5 0 5 299112;300795;313108;316273;293502 POLE2_9520;NS5ATP9_9367;MMS22L_33129;MCM3_9207;KIF22_8963 126.6903400543196 126.653 122.87719885387028 70.5272280543196 85.587 66.66537405724497 297.3054200543198 240.486 275.96829303338103 2.71598E-7;292.216;126.653;197.273;17.3097 2.71598E-7;147.515;85.587;116.413;3.12114 2.71599E-7;658.494;240.486;496.915;90.6321 0 Exp 2,1(0.2);Hill,2(0.4);Poly 2,2(0.4) 1.6544764720442917 8.290329337120056 1.540663719177246 1.8598893880844116 0.12417355106993397 1.6493386030197144 18.98372640169042 234.39695370694875 12.092451264438914 128.96200484420027 55.40854581428886 539.2022942943506 DOWN 0.0 1.0 0.0 GO:0034641 4 cellular nitrogen compound metabolic process 478 543 29 29 20 19 15 15 53 528 1951 0.62758 0.4887 0.88087 2.76 360243;25682;299112;362282;300795;313108;291234;316273;293502;24426;156275;25283;116599;25612;29221 top2a;ppard;pole2;pck1;pclaf;mms22l;mki67;mcm3;kif22;gstp1;ggt7;gclc;blvra;asns;arg1 TOP2A_10059;PPARD_9536;POLE2_9520;PCK1_9439;NS5ATP9_9367;MMS22L_33129;MKI67_9232;MCM3_9207;KIF22_8963;GSTP1_8762;GGT7_33026;GCLC_8699;BLVRA_8151;ASNS_8091;ARG1_33267 199.28384001810656 126.653 2.71598E-7 217.12534598296733 154.2426369779089 199.61651787841365 111.64680001810652 39.9158 2.71598E-7 134.8822602531322 81.15818324016283 117.23696441738889 508.97767335143993 346.073 2.71599E-7 656.1509744704476 429.79772654508497 653.9423170966909 86.3883;94.1074;2.71598E-7;529.244;292.216;126.653;21.9311;197.273;17.3097;14.7631;109.609;131.7;415.991;191.145;760.927 26.6888;37.7692;2.71598E-7;356.883;147.515;85.587;6.82654;116.413;3.12114;9.42992;29.3336;39.9158;288.048;113.564;413.607 262.273;148.485;2.71599E-7;1021.06;658.494;240.486;76.1794;496.915;90.6321;25.7196;346.073;397.209;720.942;510.267;2639.93 2 13 2 362282;24426 PCK1_9439;GSTP1_8762 272.00355 272.00355 363.7929331809581 183.15645999999998 183.15645999999998 245.686429012152 523.3897999999999 523.3897999999999 703.8119464289307 529.244;14.7631 356.883;9.42992 1021.06;25.7196 13 360243;25682;299112;300795;313108;291234;316273;293502;156275;25283;116599;25612;29221 TOP2A_10059;PPARD_9536;POLE2_9520;NS5ATP9_9367;MMS22L_33129;MKI67_9232;MCM3_9207;KIF22_8963;GGT7_33026;GCLC_8699;BLVRA_8151;ASNS_8091;ARG1_33267 188.09619232858446 126.653 207.2556968441592 100.645313867046 39.9158 123.33647352662301 506.7604230978153 346.073 678.9481345477952 86.3883;94.1074;2.71598E-7;292.216;126.653;21.9311;197.273;17.3097;109.609;131.7;415.991;191.145;760.927 26.6888;37.7692;2.71598E-7;147.515;85.587;6.82654;116.413;3.12114;29.3336;39.9158;288.048;113.564;413.607 262.273;148.485;2.71599E-7;658.494;240.486;76.1794;496.915;90.6321;346.073;397.209;720.942;510.267;2639.93 0 Exp 2,3(0.2);Exp 4,4(0.27);Exp 5,1(0.07);Hill,3(0.2);Linear,1(0.07);Poly 2,3(0.2) 1.8267136693857533 28.044342637062073 1.513624906539917 3.5281898975372314 0.4895314235313643 1.805381178855896 89.40325441131654 309.1644256248965 43.386958323971655 179.90664171224137 176.91946524645653 841.0358814564232 DOWN 0.13333333333333333 0.8666666666666667 0.0 GO:0001501 5 skeletal system development 24 27 3 3 2 2 2 2 66 25 2454 0.96631 0.16114 0.16114 7.41 81687;84032 mmp9;col3a1 MMP9_32531;COL3A1_8354 470.45950000000005 470.45950000000005 212.603 364.66415944605797 586.1173573428078 325.9240237451691 281.4735 281.4735 119.81 228.62671424070282 353.9853584194659 204.3385309764428 1774.875 1774.875 1510.69 373.6140099755355 1893.3714158053403 333.9230859532998 0.5 470.45950000000005 728.316;212.603 443.137;119.81 2039.06;1510.69 0 2 0 2 81687;84032 MMP9_32531;COL3A1_8354 470.45950000000005 470.45950000000005 364.66415944605797 281.4735 281.4735 228.62671424070282 1774.875 1774.875 373.6140099755355 728.316;212.603 443.137;119.81 2039.06;1510.69 0 Linear,1(0.5);Poly 2,1(0.5) 1.819008578403214 3.6643320322036743 1.6129854917526245 2.05134654045105 0.3099680701427029 1.8321660161018372 -34.93923999999987 975.85824 -35.38695999999999 598.3339599999999 1257.0724000000002 2292.6776 DOWN 0.0 1.0 0.0 GO:0050727 6 regulation of inflammatory response 108 115 8 8 6 5 5 5 63 110 2369 0.91633 0.1906 0.23199 4.35 688621;25682;259241;24232;81639 tslp;ppard;nr1d2;c3;alox15 TSLP_32811;PPARD_9536;NR1D2_9358;C3_8175;ALOX15_8036 293.90664 234.759 29.1728 291.4299711256342 320.9889132438317 300.61721049783296 167.103954 129.148 3.35457 169.86271854379515 186.92152295899857 174.78709929799237 835.8488000000001 560.435 114.038 1051.7219579269513 890.4702607039188 1099.4739491222585 344.675;94.1074;29.1728;234.759;766.819 244.2;37.7692;3.35457;129.148;421.048 560.435;148.485;114.038;694.216;2662.07 1 4 1 259241 NR1D2_9358 29.1728 29.1728 3.35457 3.35457 114.038 114.038 29.1728 3.35457 114.038 4 688621;25682;24232;81639 TSLP_32811;PPARD_9536;C3_8175;ALOX15_8036 360.0901 289.717 289.89693842796385 208.04129999999998 186.67399999999998 165.22312858059553 1016.3015 627.3254999999999 1121.489005503695 344.675;94.1074;234.759;766.819 244.2;37.7692;129.148;421.048 560.435;148.485;694.216;2662.07 0 Exp 2,2(0.4);Exp 4,1(0.2);Exp 5,1(0.2);Poly 2,1(0.2) 1.7534300770015623 8.85604476928711 1.5021449327468872 2.1823768615722656 0.28602240813951074 1.6858625411987305 38.45700736185415 549.3562726381458 18.212716481318665 315.9951915186813 -86.02614221070405 1757.7237422107041 DOWN 0.2 0.8 0.0 GO:0071222 6 cellular response to lipopolysaccharide 81 86 10 10 7 7 6 6 62 80 2399 0.99287 0.025458 0.025458 6.98 116669;25682;81687;24426;245920;29221 vwf;ppard;mmp9;gstp1;cxcl10;arg1 VWF_32396;PPARD_9536;MMP9_32531;GSTP1_8762;CXCL10_8408;ARG1_33267 381.3863166666667 382.3177 14.7631 373.0388910821306 351.8615134483685 382.11255497102155 213.81026 206.28560000000002 4.11644 216.86913458236256 198.7610668295958 224.91376671863156 1150.4287666666667 1051.8925 25.7196 1186.6622146666703 1074.5807926279037 1205.6183367257934 3.5 699.422 19.6764;94.1074;728.316;14.7631;670.528;760.927 4.11644;37.7692;443.137;9.42992;374.802;413.607 94.078;148.485;2039.06;25.7196;1955.3;2639.93 1 5 1 24426 GSTP1_8762 14.7631 14.7631 9.42992 9.42992 25.7196 25.7196 14.7631 9.42992 25.7196 5 116669;25682;81687;245920;29221 VWF_32396;PPARD_9536;MMP9_32531;CXCL10_8408;ARG1_33267 454.71096000000006 670.528 365.5458150834556 254.686328 374.802 215.078776043974 1375.3705999999997 1955.3 1175.039489452078 19.6764;94.1074;728.316;670.528;760.927 4.11644;37.7692;443.137;374.802;413.607 94.078;148.485;2039.06;1955.3;2639.93 0 Exp 2,2(0.34);Exp 4,1(0.17);Exp 5,1(0.17);Hill,1(0.17);Linear,1(0.17) 2.085805175842187 12.977153897285461 1.513624906539917 3.5281898975372314 0.6998375833939048 1.9951228499412537 82.89303712746926 679.8795962058641 40.27881124265119 387.3417087573489 200.9012384950363 2099.9562948382973 DOWN 0.16666666666666666 0.8333333333333334 0.0 GO:0050708 6 regulation of protein secretion 128 139 8 8 4 6 4 4 64 135 2344 0.68767 0.51421 0.78588 2.88 688621;25682;24367;29657 tslp;ppard;fgg;arntl TSLP_32811;PPARD_9536;FGG_8639;ARNTL_8086 126.03925000000001 68.2843 22.9134 148.81920306478148 156.21774156085817 159.379723890188 78.505775 29.205799999999996 11.4115 111.00128624667298 100.57797324321366 120.31309203236813 214.28314999999998 123.26920000000001 50.1592 234.23387568162863 264.7518567097198 248.70694202688338 344.675;94.1074;42.4612;22.9134 244.2;37.7692;20.6424;11.4115 560.435;148.485;98.0534;50.1592 0 4 0 4 688621;25682;24367;29657 TSLP_32811;PPARD_9536;FGG_8639;ARNTL_8086 126.03925000000001 68.2843 148.81920306478148 78.505775 29.205799999999996 111.00128624667298 214.28314999999998 123.26920000000001 234.23387568162863 344.675;94.1074;42.4612;22.9134 244.2;37.7692;20.6424;11.4115 560.435;148.485;98.0534;50.1592 0 Exp 2,1(0.25);Exp 4,2(0.5);Exp 5,1(0.25) 2.3730082874473517 9.885379195213318 1.6858625411987305 3.442979335784912 0.8092122713951931 2.3782686591148376 -19.803569003485876 271.88206900348587 -30.275485521739512 187.2870355217395 -15.266048167996047 443.832348167996 DOWN 0.0 1.0 0.0 GO:0043434 5 response to peptide hormone 194 204 13 13 8 11 7 7 61 197 2282 0.82687 0.30037 0.49271 3.43 25154;362282;24426;25283;114494;29221;170913 pgr;pck1;gstp1;gclc;ccna2;arg1;abcb1a PGR_32824;PCK1_9439;GSTP1_8762;GCLC_8699;CCNA2_8221;ARG1_33267;ABCB1A_7938 277.3740142857143 206.982 14.384 277.37013810785055 241.92158887334222 273.18412501112243 154.49481571428572 118.025 4.89199 166.4494206222363 125.33217784736586 156.97529763085777 1032.5612857142858 1021.06 25.7196 954.9483398255765 993.9367253254653 997.0675568373364 283.618;529.244;14.7631;131.7;14.384;760.927;206.982 138.711;356.883;9.42992;39.9158;4.89199;413.607;118.025 1554.21;1021.06;25.7196;397.209;58.2504;2639.93;1531.55 2 5 2 362282;24426 PCK1_9439;GSTP1_8762 272.00355 272.00355 363.7929331809581 183.15645999999998 183.15645999999998 245.686429012152 523.3897999999999 523.3897999999999 703.8119464289307 529.244;14.7631 356.883;9.42992 1021.06;25.7196 5 25154;25283;114494;29221;170913 PGR_32824;GCLC_8699;CCNA2_8221;ARG1_33267;ABCB1A_7938 279.5222 206.982 286.8706614350795 143.030158 118.025 160.91182738014888 1236.22988 1531.55 1030.8117007069097 283.618;131.7;14.384;760.927;206.982 138.711;39.9158;4.89199;413.607;118.025 1554.21;397.209;58.2504;2639.93;1531.55 0 Exp 2,1(0.15);Exp 4,2(0.29);Hill,1(0.15);Linear,1(0.15);Poly 2,2(0.29) 1.8714059745369171 13.682774186134338 1.513624906539917 3.5281898975372314 0.7155643975035113 1.6267951726913452 71.89534045199088 482.8526881194377 31.187359319863262 277.80227210870817 325.1256555283933 1739.9969159001782 DOWN 0.2857142857142857 0.7142857142857143 0.0 GO:0022604 6 regulation of cell morphogenesis 114 118 9 9 5 6 4 4 64 114 2365 0.7952 0.38749 0.55462 3.39 684352;24832;25671;29397 twf2;thy1;smad1;ccl11 TWF2_10109;THY1_33010;SMAD1_32578;CCL11_33230 286.7180750000014 80.19815 5.72311E-12 470.4409438167077 418.5972595341034 524.6123957691159 162.18304000000143 47.87908 5.72311E-12 263.8340299234738 237.25778567243188 292.50456105111806 652.5427750000015 189.65555 5.72313E-12 1059.7816035000483 945.9967969660598 1186.0769757058101 138.399;5.72311E-12;21.9973;986.476 90.7363;5.72311E-12;5.02186;552.974 299.165;5.72313E-12;80.1461;2230.86 1 3 1 29397 CCL11_33230 986.476 986.476 552.974 552.974 2230.86 2230.86 986.476 552.974 2230.86 3 684352;24832;25671 TWF2_10109;THY1_33010;SMAD1_32578 53.46543333333525 21.9973 74.37239650477204 31.919386666668572 5.02186 50.99879155441185 126.43703333333525 80.1461 154.8614289870225 138.399;5.72311E-12;21.9973 90.7363;5.72311E-12;5.02186 299.165;5.72313E-12;80.1461 0 Exp 4,1(0.25);Hill,1(0.25);Poly 2,1(0.25);Power,1(0.25) 1.8301470375014917 7.332556962966919 1.6932154893875122 1.9814788103103638 0.12106186987247525 1.8289313316345215 -174.31404994037212 747.750199940375 -96.37430932500291 420.74038932500576 -386.04319643004555 1691.1287464300485 DOWN 0.25 0.75 0.0 GO:0016101 7 diterpenoid metabolic process 22 26 6 6 5 6 5 5 63 21 2458 0.99996 4.9785E-4 4.9785E-4 19.23 25682;25154;312495;24296;113902 ppard;pgr;cyp26b1;cyp1a1;ces1d PPARD_9536;PGR_32824;CYP26B1_8418;CYP1A1_8415;CES1D_32914 83.97346 18.1872 11.0684 116.89418632570228 68.95230893057739 101.00023558255053 39.962518 10.0176 4.18343 56.752697946689906 32.71663794540552 48.48059974879841 355.16038 36.7271 17.0564 672.483315064249 259.90502341046954 572.1852409000287 0.5 11.977350000000001 1.5 15.536750000000001 94.1074;283.618;18.1872;12.8863;11.0684 37.7692;138.711;10.0176;9.13136;4.18343 148.485;1554.21;36.7271;19.3234;17.0564 2 3 2 312495;24296 CYP26B1_8418;CYP1A1_8415 15.536750000000001 15.536750000000001 3.7483023363917627 9.574480000000001 9.574480000000001 0.6266663137587598 28.02525 28.02525 12.306274287736318 18.1872;12.8863 10.0176;9.13136 36.7271;19.3234 3 25682;25154;113902 PPARD_9536;PGR_32824;CES1D_32914 129.59793333333332 94.1074 139.69790471676137 60.221210000000006 37.7692 70.01775729989001 573.2504666666667 148.485 852.0736903300402 94.1074;283.618;11.0684 37.7692;138.711;4.18343 148.485;1554.21;17.0564 0 Exp 4,2(0.4);Exp 5,2(0.4);Poly 2,1(0.2) 2.7501848776795197 22.683998227119446 1.5405861139297485 15.48720932006836 6.125564467506226 1.9388991594314575 -18.488811945128276 186.43573194512828 -9.783415082002044 89.70845108200206 -234.29723523748294 944.617995237483 DOWN 0.4 0.6 0.0 GO:0044267 5 cellular protein metabolic process 443 481 30 30 19 20 14 14 54 467 2012 0.70641 0.40666 0.7531 2.91 315852;24832;25671;291463;288583;363131;362282;362376;156275;81919;84032;297594;114494;29397 ttk;thy1;smad1;ppic;plod3;pik3r4;pck1;herc6;ggt7;fut1;col3a1;cdca3;ccna2;ccl11 TTK_32727;THY1_33010;SMAD1_32578;PPIC_9541;PLOD3_9507;PIK3R4_9484;PCK1_9439;HERC6_8794;GGT7_33026;FUT1_8668;COL3A1_8354;CDCA3_8260;CCNA2_8221;CCL11_33230 386.8430714285718 226.732 5.72311E-12 383.3108306889516 309.24332490701704 360.90719857384545 241.62539642857183 99.3913 5.72311E-12 266.1761792873294 176.84851069612364 236.7063931234578 886.8472500000005 934.4649999999999 5.72313E-12 774.3418758082189 785.3838278860602 797.0961734669207 737.351;5.72311E-12;21.9973;628.678;882.629;955.628;529.244;39.6865;109.609;240.861;212.603;56.6562;14.384;986.476 446.625;5.72311E-12;5.02186;389.239;625.677;735.228;356.883;15.7729;29.3336;78.9726;119.81;22.3266;4.89199;552.974 2108.09;5.72313E-12;80.1461;1509.86;1106.02;1288.97;1021.06;157.407;346.073;847.87;1510.69;150.565;58.2504;2230.86 2 12 2 362282;29397 PCK1_9439;CCL11_33230 757.86 757.86 323.3118477754875 454.9285 454.9285 138.65727582965147 1625.96 1625.96 855.4577838794855 529.244;986.476 356.883;552.974 1021.06;2230.86 12 315852;24832;25671;291463;288583;363131;362376;156275;81919;84032;297594;114494 TTK_32727;THY1_33010;SMAD1_32578;PPIC_9541;PLOD3_9507;PIK3R4_9484;HERC6_8794;GGT7_33026;FUT1_8668;COL3A1_8354;CDCA3_8260;CCNA2_8221 325.00691666666717 161.106 367.34072789700207 206.07487916666716 54.1531 268.9471931949792 763.6617916666672 596.9715 725.4083619859067 737.351;5.72311E-12;21.9973;628.678;882.629;955.628;39.6865;109.609;240.861;212.603;56.6562;14.384 446.625;5.72311E-12;5.02186;389.239;625.677;735.228;15.7729;29.3336;78.9726;119.81;22.3266;4.89199 2108.09;5.72313E-12;80.1461;1509.86;1106.02;1288.97;157.407;346.073;847.87;1510.69;150.565;58.2504 0 Exp 2,2(0.15);Exp 4,5(0.36);Hill,1(0.08);Linear,2(0.15);Poly 2,3(0.22);Power,1(0.08) 1.80938213850934 25.6512188911438 1.5018656253814697 2.737008571624756 0.32173943507969327 1.746735155582428 186.0525792776839 587.6335635794599 102.19378699065368 381.05700586648993 481.2221700691308 1292.4723299308703 DOWN 0.14285714285714285 0.8571428571428571 0.0 GO:0050865 5 regulation of cell activation 163 173 11 11 7 9 6 6 62 167 2312 0.8248 0.31395 0.46142 3.47 688621;24832;25283;24367;312495;29221 tslp;thy1;gclc;fgg;cyp26b1;arg1 TSLP_32811;THY1_33010;GCLC_8699;FGG_8639;CYP26B1_8418;ARG1_33267 216.3250666666676 87.08059999999999 5.72311E-12 295.4691746674265 209.9296478841151 276.70205930354706 121.3971333333343 30.2791 5.72311E-12 169.94148324458743 115.94967705620711 161.5953017605464 622.0590833333342 247.6312 5.72313E-12 1012.9472951725495 592.349050477431 944.1222157823005 344.675;5.72311E-12;131.7;42.4612;18.1872;760.927 244.2;5.72311E-12;39.9158;20.6424;10.0176;413.607 560.435;5.72313E-12;397.209;98.0534;36.7271;2639.93 1 5 1 312495 CYP26B1_8418 18.1872 18.1872 10.0176 10.0176 36.7271 36.7271 18.1872 10.0176 36.7271 5 688621;24832;25283;24367;29221 TSLP_32811;THY1_33010;GCLC_8699;FGG_8639;ARG1_33267 255.95264000000117 131.7 312.00954666668014 143.67304000000115 39.9158 179.94030822900018 739.1254800000012 397.209 1086.1830965738925 344.675;5.72311E-12;131.7;42.4612;760.927 244.2;5.72311E-12;39.9158;20.6424;413.607 560.435;5.72313E-12;397.209;98.0534;2639.93 0 Exp 2,2(0.34);Exp 4,2(0.34);Hill,2(0.34) 1.9518664983716367 11.945353627204895 1.513624906539917 2.8176381587982178 0.4540466291051395 1.9189465641975403 -20.099512801113406 452.74964613444865 -14.584373893117942 257.3786405597865 -188.467559771673 1432.5857264383415 DOWN 0.16666666666666666 0.8333333333333334 0.0 GO:0044070 7 regulation of anion transport 43 45 5 4 4 3 3 3 65 42 2437 0.96957 0.11684 0.11684 6.67 113902;29221;170913 ces1d;arg1;abcb1a CES1D_32914;ARG1_33267;ABCB1A_7938 326.3258 206.982 11.0684 388.91411255869855 400.9186890145877 363.5700498885486 178.60514333333333 118.025 4.18343 211.3276608553685 220.34946292200058 195.89055093210294 1396.1788 1531.55 17.0564 1316.6664352584978 1779.7427801131287 1030.8298992558096 1.5 483.9545 11.0684;760.927;206.982 4.18343;413.607;118.025 17.0564;2639.93;1531.55 0 3 0 3 113902;29221;170913 CES1D_32914;ARG1_33267;ABCB1A_7938 326.3258 206.982 388.91411255869855 178.60514333333333 118.025 211.3276608553685 1396.1788 1531.55 1316.6664352584978 11.0684;760.927;206.982 4.18343;413.607;118.025 17.0564;2639.93;1531.55 0 Exp 2,1(0.34);Exp 5,1(0.34);Poly 2,1(0.34) 1.6688847195574512 5.028070092201233 1.513624906539917 1.8874764442443848 0.1916924882813877 1.6269687414169312 -113.77194845172158 766.4235484517217 -60.53461715550611 417.7449038221728 -93.7695328256998 2886.1271328257 DOWN 0.0 1.0 0.0 GO:0034645 5 cellular macromolecule biosynthetic process 143 162 6 6 5 4 4 4 64 158 2321 0.56286 0.63827 1.0 2.47 25682;299112;300795;156275 ppard;pole2;pclaf;ggt7 PPARD_9536;POLE2_9520;NS5ATP9_9367;GGT7_33026 123.9831000678995 101.8582 2.71598E-7 122.16558416342532 77.56042348448086 105.22047011881041 53.654450067899496 33.5514 2.71598E-7 64.63344782758928 31.537802751260323 51.74683150750436 288.2630000678997 247.279 2.71599E-7 284.6321812195617 181.3799340766979 250.39027279352698 94.1074;2.71598E-7;292.216;109.609 37.7692;2.71598E-7;147.515;29.3336 148.485;2.71599E-7;658.494;346.073 0 4 0 4 25682;299112;300795;156275 PPARD_9536;POLE2_9520;NS5ATP9_9367;GGT7_33026 123.9831000678995 101.8582 122.16558416342532 53.654450067899496 33.5514 64.63344782758928 288.2630000678997 247.279 284.6321812195617 94.1074;2.71598E-7;292.216;109.609 37.7692;2.71598E-7;147.515;29.3336 148.485;2.71599E-7;658.494;346.073 0 Exp 2,1(0.25);Exp 4,1(0.25);Exp 5,1(0.25);Hill,1(0.25) 1.7909287396257219 7.185173511505127 1.6493386030197144 1.9388991594314575 0.16016417454234508 1.7984678745269775 4.260827587742654 243.70537254805632 -9.686328803137997 116.99522893893699 9.323462472729375 567.2025376630701 DOWN 0.0 1.0 0.0 GO:0002376 2 immune system process 352 390 27 26 13 16 9 9 59 381 2098 0.39113 0.73573 0.73452 2.31 688621;24832;295703;304545;245920;24854;29397;24232;29221 tslp;thy1;serping1;oasl;cxcl10;clu;ccl11;c3;arg1 TSLP_32811;THY1_33010;SERPING1_32597;OASL_9389;CXCL10_8408;CLU_32773;CCL11_33230;C3_8175;ARG1_33267 449.11403333333396 344.675 5.72311E-12 394.12764242730344 504.41768929077637 393.1789141612325 285.04372222222287 244.2 5.72311E-12 277.72181512896873 323.18520279130007 273.6101031106861 1056.8520555555563 694.216 5.72313E-12 983.4639144273549 1161.4412829502749 1026.3292897528484 344.675;5.72311E-12;32.3997;76.6126;670.528;935.649;986.476;234.759;760.927 244.2;5.72311E-12;13.7308;28.4477;374.802;808.484;552.974;129.148;413.607 560.435;5.72313E-12;99.4885;260.389;1955.3;1071.05;2230.86;694.216;2639.93 1 8 1 29397 CCL11_33230 986.476 986.476 552.974 552.974 2230.86 2230.86 986.476 552.974 2230.86 8 688621;24832;295703;304545;245920;24854;24232;29221 TSLP_32811;THY1_33010;SERPING1_32597;OASL_9389;CXCL10_8408;CLU_32773;C3_8175;ARG1_33267 381.9437875000007 289.717 362.1049906114611 251.55243750000074 186.67399999999998 276.7864803209961 910.1010625000008 627.3254999999999 940.138947369347 344.675;5.72311E-12;32.3997;76.6126;670.528;935.649;234.759;760.927 244.2;5.72311E-12;13.7308;28.4477;374.802;808.484;129.148;413.607 560.435;5.72313E-12;99.4885;260.389;1955.3;1071.05;694.216;2639.93 0 Exp 2,3(0.34);Exp 4,2(0.23);Hill,1(0.12);Poly 2,2(0.23);Power,1(0.12) 1.7269261002721532 15.610656499862671 1.513624906539917 1.9814788103103638 0.17167121004020802 1.7183171510696411 191.61730694749576 706.6107597191723 103.59880300463007 466.48864143981575 414.3222981296841 1699.381812981428 DOWN 0.1111111111111111 0.8888888888888888 0.0 GO:0048145 6 regulation of fibroblast proliferation 37 41 7 7 4 5 4 4 64 37 2442 0.99584 0.022393 0.022393 9.76 24832;81687;24426;114494 thy1;mmp9;gstp1;ccna2 THY1_33010;MMP9_32531;GSTP1_8762;CCNA2_8221 189.36577500000143 14.573550000000001 5.72311E-12 359.36585697039783 264.84565383967237 396.4830046251901 114.36472750000144 7.1609549999999995 5.72311E-12 219.2153371624715 160.05792097914352 242.1576945969287 530.7575000000014 41.985 5.72313E-12 1005.8174445526572 744.2753629411154 1107.7531915456893 1.5 14.573550000000001 5.72311E-12;728.316;14.7631;14.384 5.72311E-12;443.137;9.42992;4.89199 5.72313E-12;2039.06;25.7196;58.2504 1 3 1 24426 GSTP1_8762 14.7631 14.7631 9.42992 9.42992 25.7196 25.7196 14.7631 9.42992 25.7196 3 24832;81687;114494 THY1_33010;MMP9_32531;CCNA2_8221 247.56666666666857 14.384 416.4032492540517 149.34299666666857 4.89199 254.44482739389534 699.1034666666686 58.2504 1160.8018395454278 5.72311E-12;728.316;14.384 5.72311E-12;443.137;4.89199 5.72313E-12;2039.06;58.2504 0 Exp 4,2(0.5);Hill,1(0.25);Linear,1(0.25) 2.164193394772239 9.069535613059998 1.6267951726913452 3.5281898975372314 0.8582966098308656 1.9572752714157104 -162.81276483098844 541.5443148309914 -100.46630291922061 329.19575791922347 -454.9435956616028 1516.4585956616056 DOWN 0.25 0.75 0.0 GO:0034767 7 positive regulation of ion transmembrane transport 41 43 7 7 4 6 4 4 64 39 2440 0.99487 0.026226 0.026226 9.3 24832;245920;686019;170913 thy1;cxcl10;casq1;abcb1a THY1_33010;CXCL10_8408;CASQ1_32992;ABCB1A_7938 256.29250000000144 177.321 5.72311E-12 289.54529897927716 178.2706264084688 173.97239733790053 147.35732500000142 107.31365 5.72311E-12 160.08510160709923 106.72050825325688 96.19340653799557 943.1557500000015 908.6614999999999 5.72313E-12 947.3363754930168 747.2701354568079 802.5122215247585 1.5 177.321 5.72311E-12;670.528;147.66;206.982 5.72311E-12;374.802;96.6023;118.025 5.72313E-12;1955.3;285.773;1531.55 0 4 0 4 24832;245920;686019;170913 THY1_33010;CXCL10_8408;CASQ1_32992;ABCB1A_7938 256.29250000000144 177.321 289.54529897927716 147.35732500000142 107.31365 160.08510160709923 943.1557500000015 908.6614999999999 947.3363754930168 5.72311E-12;670.528;147.66;206.982 5.72311E-12;374.802;96.6023;118.025 5.72313E-12;1955.3;285.773;1531.55 0 Exp 2,1(0.25);Hill,1(0.25);Poly 2,2(0.5) 1.9735752735753285 7.931551933288574 1.8538048267364502 2.327066659927368 0.22989058254389025 1.875340223312378 -27.461892999690235 540.0468929996931 -9.526074574955771 304.2407245749586 14.766102016844684 1871.5453979831582 DOWN 0.0 1.0 0.0 GO:0016567 9 protein ubiquitination 75 76 5 5 3 3 2 2 66 74 2405 0.66873 0.60962 1.0 2.63 362376;297594 herc6;cdca3 HERC6_8794;CDCA3_8260 48.171350000000004 48.171350000000004 39.6865 11.999389944701328 50.77472167186865 11.420607292137413 19.04975 19.04975 15.7729 4.6341657118622726 20.05517242502375 4.410639788003393 153.986 153.986 150.565 4.838024596879707 152.93634862260822 4.604665674278925 39.6865;56.6562 15.7729;22.3266 157.407;150.565 0 2 0 2 362376;297594 HERC6_8794;CDCA3_8260 48.171350000000004 48.171350000000004 11.999389944701328 19.04975 19.04975 4.6341657118622726 153.986 153.986 4.838024596879707 39.6865;56.6562 15.7729;22.3266 157.407;150.565 0 Exp 4,2(1) 1.8619770190733482 3.727978467941284 1.7774014472961426 1.9505770206451416 0.12245362225094557 1.863989233970642 31.54104400000001 64.801656 12.627124 25.472375999999997 147.28083999999998 160.69116 DOWN 0.0 1.0 0.0 GO:0022402 3 cell cycle process 177 191 20 20 15 13 11 11 57 180 2299 0.99613 0.010931 0.015564 5.76 315852;360243;295661;300795;316273;293502;361921;312495;306575;114494;170913 ttk;top2a;spc25;pclaf;mcm3;kif22;ect2;cyp26b1;ckap2;ccna2;abcb1a TTK_32727;TOP2A_10059;SPC25_9925;NS5ATP9_9367;MCM3_9207;KIF22_8963;ECT2_8523;CYP26B1_8418;CKAP2_8324;CCNA2_8221;ABCB1A_7938 149.83966363636364 35.8903 10.0162 217.85125727019928 102.67512177154164 182.81884856366608 82.13038909090909 15.2683 3.12114 132.56745453973494 53.98168742913684 111.50036149686335 498.3066636363637 124.006 36.7271 695.9346904717299 385.91002111982374 637.6077865133581 8.5 249.599 737.351;86.3883;35.8903;292.216;197.273;17.3097;10.0162;18.1872;32.2386;14.384;206.982 446.625;26.6888;11.5744;147.515;116.413;3.12114;3.29405;10.0176;15.2683;4.89199;118.025 2108.09;262.273;124.006;658.494;496.915;90.6321;37.7305;36.7271;76.7052;58.2504;1531.55 1 10 1 312495 CYP26B1_8418 18.1872 18.1872 10.0176 10.0176 36.7271 36.7271 18.1872 10.0176 36.7271 10 315852;360243;295661;300795;316273;293502;361921;306575;114494;170913 TTK_32727;TOP2A_10059;SPC25_9925;NS5ATP9_9367;MCM3_9207;KIF22_8963;ECT2_8523;CKAP2_8324;CCNA2_8221;ABCB1A_7938 163.00491 61.139300000000006 224.97557759859404 89.341668 20.97855 137.4453508554218 544.46462 193.1395 715.610824641471 737.351;86.3883;35.8903;292.216;197.273;17.3097;10.0162;32.2386;14.384;206.982 446.625;26.6888;11.5744;147.515;116.413;3.12114;3.29405;15.2683;4.89199;118.025 2108.09;262.273;124.006;658.494;496.915;90.6321;37.7305;76.7052;58.2504;1531.55 0 Exp 2,1(0.1);Exp 4,6(0.55);Hill,1(0.1);Linear,1(0.1);Poly 2,2(0.19) 1.75862294522646 19.46383774280548 1.5111545324325562 2.090334892272949 0.207264443405214 1.6661498546600342 21.09779766127525 278.5815296114521 3.7880298184761045 160.47274836334208 87.0355432819793 909.5777839907482 DOWN 0.09090909090909091 0.9090909090909091 0.0 GO:0042060 5 wound healing 52 55 9 9 5 7 4 4 64 51 2428 0.98552 0.057185 0.057185 7.27 25671;25682;84032;81639 smad1;ppard;col3a1;alox15 SMAD1_32578;PPARD_9536;COL3A1_8354;ALOX15_8036 273.881675 153.3552 21.9973 337.88894167010335 377.4065311799969 368.70174612979497 145.912265 78.78960000000001 5.02186 189.67167214318775 202.8749865609718 207.4372574247142 1100.3477750000002 829.5875000000001 80.1461 1232.1000026757035 1411.1152979728665 1305.76692253475 1.5 153.3552 21.9973;94.1074;212.603;766.819 5.02186;37.7692;119.81;421.048 80.1461;148.485;1510.69;2662.07 0 4 0 4 25671;25682;84032;81639 SMAD1_32578;PPARD_9536;COL3A1_8354;ALOX15_8036 273.881675 153.3552 337.88894167010335 145.912265 78.78960000000001 189.67167214318775 1100.3477750000002 829.5875000000001 1232.1000026757035 21.9973;94.1074;212.603;766.819 5.02186;37.7692;119.81;421.048 80.1461;148.485;1510.69;2662.07 0 Exp 2,1(0.25);Exp 4,1(0.25);Exp 5,1(0.25);Poly 2,1(0.25) 1.6793933854297067 6.7472450733184814 1.5021449327468872 1.9388991594314575 0.1854195420052241 1.6531004905700684 -57.24948783670129 605.0128378367012 -39.965973700323985 331.79050370032394 -107.11022762218977 2307.8057776221895 DOWN 0.0 1.0 0.0 GO:0050877 4 nervous system process 155 163 7 7 3 5 2 2 66 161 2318 0.17776 0.93946 0.31864 1.23 170945;29397 chrna2;ccl11 CHRNA2_32401;CCL11_33230 574.9775 574.9775 163.479 581.9467595961852 463.7608502677831 560.2889831588542 327.471 327.471 101.968 318.9094009558201 266.5237835105982 307.0408435736001 1322.611 1322.611 414.362 1284.4580538118012 1077.1364456513543 1236.6555617214792 163.479;986.476 101.968;552.974 414.362;2230.86 1 1 1 29397 CCL11_33230 986.476 986.476 552.974 552.974 2230.86 2230.86 986.476 552.974 2230.86 1 170945 CHRNA2_32401 163.479 163.479 101.968 101.968 414.362 414.362 163.479 101.968 414.362 0 Poly 2,1(0.5);Power,1(0.5) 1.887843327069435 3.7801114320755005 1.7986326217651367 1.9814788103103638 0.12929177983444406 1.8900557160377502 -231.55956000000003 1381.51456 -114.51487999999995 769.45688 -457.55703999999946 3102.7790399999994 CONFLICT 0.5 0.5 0.0 GO:0031349 6 positive regulation of defense response 74 79 7 7 5 5 4 4 64 75 2404 0.94248 0.15799 0.15799 5.06 688621;316351;24232;29221 tslp;npas2;c3;arg1 TSLP_32811;NPAS2_9350;C3_8175;ARG1_33267 340.36220000000003 289.717 21.0878 310.9027337654441 356.7444021273284 321.6910543843211 199.571375 186.67399999999998 11.3305 171.4614064502442 212.59328700773105 176.55972991786894 984.53585 627.3254999999999 43.5624 1138.6992537882672 1007.4035082031858 1190.9544567784933 2.5 552.801 344.675;21.0878;234.759;760.927 244.2;11.3305;129.148;413.607 560.435;43.5624;694.216;2639.93 0 4 0 4 688621;316351;24232;29221 TSLP_32811;NPAS2_9350;C3_8175;ARG1_33267 340.36220000000003 289.717 310.9027337654441 199.571375 186.67399999999998 171.4614064502442 984.53585 627.3254999999999 1138.6992537882672 344.675;21.0878;234.759;760.927 244.2;11.3305;129.148;413.607 560.435;43.5624;694.216;2639.93 0 Exp 2,2(0.5);Exp 4,1(0.25);Poly 2,1(0.25) 1.8679316280182423 7.830716133117676 1.513624906539917 3.0844674110412598 0.7548893353143938 1.6163119077682495 35.67752090986477 645.0468790901352 31.539196678760703 367.60355332123936 -131.389418712502 2100.461118712502 DOWN 0.0 1.0 0.0 GO:2001016 7 positive regulation of skeletal muscle cell differentiation 4 4 2 2 2 2 2 2 66 2 2477 0.99993 0.0040711 0.0040711 50.0 312495;29657 cyp26b1;arntl CYP26B1_8418;ARNTL_8086 20.5503 20.5503 18.1872 3.3419280692438758 18.924951319417094 2.425895000418341 10.71455 10.71455 10.0176 0.9856361422959365 10.235185282919785 0.7154701538410017 43.44315 43.44315 36.7271 9.497928995575775 38.82382665091244 6.8945165746518455 0.0 18.1872 0.0 18.1872 18.1872;22.9134 10.0176;11.4115 36.7271;50.1592 1 1 1 312495 CYP26B1_8418 18.1872 18.1872 10.0176 10.0176 36.7271 36.7271 18.1872 10.0176 36.7271 1 29657 ARNTL_8086 22.9134 22.9134 11.4115 11.4115 50.1592 50.1592 22.9134 11.4115 50.1592 0 Exp 4,2(1) 2.682718740189874 5.533314228057861 2.090334892272949 3.442979335784912 0.9564640585416129 2.7666571140289307 15.918624000000001 25.181976 9.348527999999998 12.080572 30.279692000000004 56.606608 CONFLICT 0.5 0.5 0.0 GO:0048856 3 anatomical structure development 699 756 55 52 34 36 27 27 41 729 1750 0.97313 0.047175 0.07954 3.57 116669;360243;24832;25671;25682;288583;25154;338475;81687;291234;24426;81919;25315;361921;64191;312495;24296;84032;24854;114494;686019;24232;25612;29221;81639;24646;170913 vwf;top2a;thy1;smad1;ppard;plod3;pgr;nrep;mmp9;mki67;gstp1;fut1;ephx1;ect2;dhcr7;cyp26b1;cyp1a1;col3a1;clu;ccna2;casq1;c3;asns;arg1;alox15;abcb1b;abcb1a VWF_32396;TOP2A_10059;THY1_33010;SMAD1_32578;PPARD_9536;PLOD3_9507;PGR_32824;NREP_9364;MMP9_32531;MKI67_9232;GSTP1_8762;FUT1_8668;EPHX1_8567;ECT2_8523;DHCR7_8466;CYP26B1_8418;CYP1A1_8415;COL3A1_8354;CLU_32773;CCNA2_8221;CASQ1_32992;C3_8175;ASNS_8091;ARG1_33267;ALOX15_8036;ABCB1B_7939;ABCB1A_7938 229.24379629629652 94.1074 5.72311E-12 298.94441196785596 205.9809320530995 273.14438029595607 138.06542629629652 37.7692 5.72311E-12 212.4986906383188 117.87454648526926 187.33133391942852 668.9196851851855 262.273 5.72313E-12 819.7586073790478 628.7260218850163 806.44791632624 19.6764;86.3883;5.72311E-12;21.9973;94.1074;882.629;283.618;61.543;728.316;21.9311;14.7631;240.861;39.2381;10.0162;161.702;18.1872;12.8863;212.603;935.649;14.384;147.66;234.759;191.145;760.927;766.819;20.7941;206.982 4.11644;26.6888;5.72311E-12;5.02186;37.7692;625.677;138.711;25.6719;443.137;6.82654;9.42992;78.9726;18.9587;3.29405;50.9087;10.0176;9.13136;119.81;808.484;4.89199;96.6023;129.148;113.564;413.607;421.048;8.25355;118.025 94.078;262.273;5.72313E-12;80.1461;148.485;1106.02;1554.21;148.788;2039.06;76.1794;25.7196;847.87;81.6965;37.7305;481.517;36.7271;19.3234;1510.69;1071.05;58.2504;285.773;694.216;510.267;2639.93;2662.07;57.2115;1531.55 4 23 4 24426;25315;312495;24296 GSTP1_8762;EPHX1_8567;CYP26B1_8418;CYP1A1_8415 21.268675 16.47515 12.178976964801548 11.884395 9.723759999999999 4.7305519072619875 40.86665 31.22335 28.152899610815698 14.7631;39.2381;18.1872;12.8863 9.42992;18.9587;10.0176;9.13136 25.7196;81.6965;36.7271;19.3234 23 116669;360243;24832;25671;25682;288583;25154;338475;81687;291234;81919;361921;64191;84032;24854;114494;686019;24232;25612;29221;81639;24646;170913 VWF_32396;TOP2A_10059;THY1_33010;SMAD1_32578;PPARD_9536;PLOD3_9507;PGR_32824;NREP_9364;MMP9_32531;MKI67_9232;FUT1_8668;ECT2_8523;DHCR7_8466;COL3A1_8354;CLU_32773;CCNA2_8221;CASQ1_32992;C3_8175;ASNS_8091;ARG1_33267;ALOX15_8036;ABCB1B_7939;ABCB1A_7938 265.4133826086959 161.702 310.42585957638244 160.00995347826114 78.9726 223.5273375912022 778.1463000000003 481.517 842.5482961218509 19.6764;86.3883;5.72311E-12;21.9973;94.1074;882.629;283.618;61.543;728.316;21.9311;240.861;10.0162;161.702;212.603;935.649;14.384;147.66;234.759;191.145;760.927;766.819;20.7941;206.982 4.11644;26.6888;5.72311E-12;5.02186;37.7692;625.677;138.711;25.6719;443.137;6.82654;78.9726;3.29405;50.9087;119.81;808.484;4.89199;96.6023;129.148;113.564;413.607;421.048;8.25355;118.025 94.078;262.273;5.72313E-12;80.1461;148.485;1106.02;1554.21;148.788;2039.06;76.1794;847.87;37.7305;481.517;1510.69;1071.05;58.2504;285.773;694.216;510.267;2639.93;2662.07;57.2115;1531.55 0 Exp 2,3(0.12);Exp 4,11(0.41);Exp 5,1(0.04);Hill,3(0.12);Linear,1(0.04);Poly 2,8(0.3) 2.1163395103531952 69.45126485824585 1.5021449327468872 15.48720932006836 2.7421126606176185 1.863204002380371 116.48131363767745 342.0062789549155 57.91045781787862 218.2203947747144 359.70495479319214 978.1344155771785 DOWN 0.14814814814814814 0.8518518518518519 0.0 GO:1901990 7 regulation of mitotic cell cycle phase transition 75 79 5 5 3 3 2 2 66 77 2402 0.64644 0.63099 1.0 2.53 315852;24296 ttk;cyp1a1 TTK_32727;CYP1A1_8415 375.11865 375.11865 12.8863 512.2739021002778 403.3490577729079 510.7158103358418 227.87818 227.87818 9.13136 309.35471956998623 244.92611049993153 308.413810734156 1063.7067000000002 1063.7067000000002 19.3234 1476.9810271759688 1145.1002211203945 1472.4887585570996 737.351;12.8863 446.625;9.13136 2108.09;19.3234 1 1 1 24296 CYP1A1_8415 12.8863 12.8863 9.13136 9.13136 19.3234 19.3234 12.8863 9.13136 19.3234 1 315852 TTK_32727 737.351 737.351 446.625 446.625 2108.09 2108.09 737.351 446.625 2108.09 0 Exp 4,1(0.5);Linear,1(0.5) 4.837723282573428 16.998363852500916 1.5111545324325562 15.48720932006836 9.88256311457199 8.499181926250458 -334.856756 1085.094056 -200.8655872 656.6219472 -983.2845679999996 3110.697968 CONFLICT 0.5 0.5 0.0 GO:0051301 3 cell division 78 79 5 5 4 3 3 3 65 76 2403 0.84201 0.35356 0.46755 3.8 360243;295661;297594 top2a;spc25;cdca3 TOP2A_10059;SPC25_9925;CDCA3_8260 59.644933333333334 56.6562 35.8903 25.381319827844525 57.28247634877787 24.57975183404192 20.1966 22.3266 11.5744 7.779071078220081 19.59278658432866 7.764955303262005 178.948 150.565 124.006 73.37327060312903 171.7896261509448 70.00495110548347 86.3883;35.8903;56.6562 26.6888;11.5744;22.3266 262.273;124.006;150.565 0 3 0 3 360243;295661;297594 TOP2A_10059;SPC25_9925;CDCA3_8260 59.644933333333334 56.6562 25.381319827844525 20.1966 22.3266 7.779071078220081 178.948 150.565 73.37327060312903 86.3883;35.8903;56.6562 26.6888;11.5744;22.3266 262.273;124.006;150.565 0 Exp 4,3(1) 1.8264284686511316 5.504274487495422 1.5933629274368286 1.9603345394134521 0.2091113266324395 1.9505770206451416 30.923266136745056 88.36660052992161 11.393752389131041 28.99944761086896 95.91832803328198 261.97767196671805 DOWN 0.0 1.0 0.0 GO:0033540 8 fatty acid beta-oxidation using acyl-CoA oxidase 3 3 1 1 1 1 1 1 67 2 2477 0.99793 0.078005 0.078005 33.33 252898 acox2 ACOX2_32902 743.353 743.353 743.353 743.353 432.537 432.537 432.537 432.537 2287.79 2287.79 2287.79 2287.79 0.0 743.353 0.0 743.353 743.353 432.537 2287.79 0 1 0 1 252898 ACOX2_32902 743.353 743.353 432.537 432.537 2287.79 2287.79 743.353 432.537 2287.79 0 Exp 2,1(1) 1.5319663286209106 1.5319663286209106 1.5319663286209106 1.5319663286209106 0.0 1.5319663286209106 743.353 743.353 432.537 432.537 2287.79 2287.79 DOWN 0.0 1.0 0.0 GO:2000379 7 positive regulation of reactive oxygen species metabolic process 59 62 4 4 3 3 2 2 66 60 2419 0.77146 0.49803 0.68099 3.23 24426;24854 gstp1;clu GSTP1_8762;CLU_32773 475.20605 475.20605 14.7631 651.1646645890769 522.1156680514343 647.7765014863861 408.95696000000004 408.95696000000004 9.42992 565.0165585027781 449.66050611275966 562.0766442844038 548.3847999999999 548.3847999999999 25.7196 739.1602144204461 601.6335790306626 735.3141897485505 14.7631;935.649 9.42992;808.484 25.7196;1071.05 1 1 1 24426 GSTP1_8762 14.7631 14.7631 9.42992 9.42992 25.7196 25.7196 14.7631 9.42992 25.7196 1 24854 CLU_32773 935.649 935.649 808.484 808.484 1071.05 1071.05 935.649 808.484 1071.05 0 Exp 4,1(0.5);Poly 2,1(0.5) 2.342186577681284 5.083048939704895 1.5548590421676636 3.5281898975372314 1.3953556293564717 2.5415244698524475 -427.26213199999995 1377.6742319999998 -374.1160384 1192.0299584 -476.038992 1572.808592 CONFLICT 0.5 0.5 0.0 GO:0046394 6 carboxylic acid biosynthetic process 88 95 6 6 6 5 5 5 63 90 2389 0.96096 0.10713 0.10713 5.26 288583;24426;24296;25612;81639 plod3;gstp1;cyp1a1;asns;alox15 PLOD3_9507;GSTP1_8762;CYP1A1_8415;ASNS_8091;ALOX15_8036 373.64848 191.145 12.8863 420.0892209533434 337.55551443381177 376.50798157287295 235.770056 113.564 9.13136 275.62865295739863 201.12867491626793 230.2831094147791 864.68 510.267 19.3234 1099.1981982564291 940.7584076555023 1161.8784190134788 3.5 824.7239999999999 882.629;14.7631;12.8863;191.145;766.819 625.677;9.42992;9.13136;113.564;421.048 1106.02;25.7196;19.3234;510.267;2662.07 2 3 2 24426;24296 GSTP1_8762;CYP1A1_8415 13.8247 13.8247 1.3270980069309275 9.28064 9.28064 0.2111138005910525 22.5215 22.5215 4.522796393825391 14.7631;12.8863 9.42992;9.13136 25.7196;19.3234 3 288583;25612;81639 PLOD3_9507;ASNS_8091;ALOX15_8036 613.531 766.819 370.35177706067515 386.763 421.048 257.7722388291649 1426.119 1106.02 1111.0407576020784 882.629;191.145;766.819 625.677;113.564;421.048 1106.02;510.267;2662.07 0 Exp 2,1(0.2);Exp 4,2(0.4);Poly 2,2(0.4) 3.027388214589563 24.038994193077087 1.5021449327468872 15.48720932006836 6.024696279880446 1.805381178855896 5.424042570690915 741.8729174293092 -5.829110587301074 477.3692225873011 -98.80970168229317 1828.1697016822932 DOWN 0.4 0.6 0.0 GO:0002687 6 positive regulation of leukocyte migration 57 58 5 5 4 4 3 3 65 55 2424 0.93293 0.2004 0.2004 5.17 24832;81687;245920 thy1;mmp9;cxcl10 THY1_33010;MMP9_32531;CXCL10_8408 466.2813333333352 670.528 5.72311E-12 404.8438891688137 507.8131989933195 400.9972361103275 272.64633333333524 374.802 5.72311E-12 238.57794400642274 304.88600529376197 241.8508911882834 1331.4533333333352 1955.3 5.72313E-12 1153.8327082091778 1431.3358170615309 1128.943081809126 1.5 699.422 5.72311E-12;728.316;670.528 5.72311E-12;443.137;374.802 5.72313E-12;2039.06;1955.3 0 3 0 3 24832;81687;245920 THY1_33010;MMP9_32531;CXCL10_8408 466.2813333333352 670.528 404.8438891688137 272.64633333333524 374.802 238.57794400642274 1331.4533333333352 1955.3 1153.8327082091778 5.72311E-12;728.316;670.528 5.72311E-12;443.137;374.802 5.72313E-12;2039.06;1955.3 0 Exp 2,1(0.34);Hill,1(0.34);Linear,1(0.34) 1.9206776531671639 5.768355369567871 1.8538048267364502 2.05134654045105 0.1114365946714116 1.863204002380371 8.157345686211613 924.405320980459 2.6699745514966366 542.6226921151738 25.768708951982262 2637.137957714688 DOWN 0.0 1.0 0.0 GO:1901576 4 organic substance biosynthetic process 397 444 24 24 20 18 16 16 52 428 2051 0.92944 0.12068 0.19376 3.6 25682;299112;288583;362282;300795;24426;156275;25283;25315;64191;312495;24296;113902;25612;29221;81639 ppard;pole2;plod3;pck1;pclaf;gstp1;ggt7;gclc;ephx1;dhcr7;cyp26b1;cyp1a1;ces1d;asns;arg1;alox15 PPARD_9536;POLE2_9520;PLOD3_9507;PCK1_9439;NS5ATP9_9367;GSTP1_8762;GGT7_33026;GCLC_8699;EPHX1_8567;DHCR7_8466;CYP26B1_8418;CYP1A1_8415;CES1D_32914;ASNS_8091;ARG1_33267;ALOX15_8036 251.01509376697487 120.65449999999998 2.71598E-7 306.23340626060366 211.67453379232265 275.3633032362034 142.99639439197486 38.8425 2.71598E-7 196.94345031978384 109.98816620901734 165.76900131368797 634.4780000169749 371.64099999999996 2.71599E-7 860.8320483090646 615.4800311080025 882.9636342912668 94.1074;2.71598E-7;882.629;529.244;292.216;14.7631;109.609;131.7;39.2381;161.702;18.1872;12.8863;11.0684;191.145;760.927;766.819 37.7692;2.71598E-7;625.677;356.883;147.515;9.42992;29.3336;39.9158;18.9587;50.9087;10.0176;9.13136;4.18343;113.564;413.607;421.048 148.485;2.71599E-7;1106.02;1021.06;658.494;25.7196;346.073;397.209;81.6965;481.517;36.7271;19.3234;17.0564;510.267;2639.93;2662.07 5 11 5 362282;24426;25315;312495;24296 PCK1_9439;GSTP1_8762;EPHX1_8567;CYP26B1_8418;CYP1A1_8415 122.86374 18.1872 227.41818698534868 80.88411599999999 10.0176 154.34244743880305 236.90532 36.7271 439.033301691588 529.244;14.7631;39.2381;18.1872;12.8863 356.883;9.42992;18.9587;10.0176;9.13136 1021.06;25.7196;81.6965;36.7271;19.3234 11 25682;299112;288583;300795;156275;25283;64191;113902;25612;29221;81639 PPARD_9536;POLE2_9520;PLOD3_9507;NS5ATP9_9367;GGT7_33026;GCLC_8699;DHCR7_8466;CES1D_32914;ASNS_8091;ARG1_33267;ALOX15_8036 309.2657091155998 161.702 328.68967676636834 171.22924820650894 50.9087 214.11603513456583 815.1928545701453 481.517 958.9014363460677 94.1074;2.71598E-7;882.629;292.216;109.609;131.7;161.702;11.0684;191.145;760.927;766.819 37.7692;2.71598E-7;625.677;147.515;29.3336;39.9158;50.9087;4.18343;113.564;413.607;421.048 148.485;2.71599E-7;1106.02;658.494;346.073;397.209;481.517;17.0564;510.267;2639.93;2662.07 0 Exp 2,3(0.19);Exp 4,6(0.38);Exp 5,2(0.13);Hill,2(0.13);Linear,1(0.07);Poly 2,2(0.13) 2.112554112833181 43.88242769241333 1.5021449327468872 15.48720932006836 3.431285115689925 1.7990894317626953 100.96072469927907 401.0694628346707 46.49410373528083 239.49868504866896 212.6702963455333 1056.2857036884166 DOWN 0.3125 0.6875 0.0 GO:0051493 7 regulation of cytoskeleton organization 126 131 9 9 7 7 5 5 63 126 2353 0.86605 0.27002 0.39583 3.82 684352;361921;306575;29397;81639 twf2;ect2;ckap2;ccl11;alox15 TWF2_10109;ECT2_8523;CKAP2_8324;CCL11_33230;ALOX15_8036 386.78976 138.399 10.0162 456.45608220455114 341.69635108307193 453.97817909045926 216.66413000000003 90.7363 3.29405 253.38803480270036 190.0655775253446 253.03745132110114 1061.3061400000001 299.165 37.7305 1277.5275325852856 945.4049764276858 1270.6044734512577 138.399;10.0162;32.2386;986.476;766.819 90.7363;3.29405;15.2683;552.974;421.048 299.165;37.7305;76.7052;2230.86;2662.07 1 4 1 29397 CCL11_33230 986.476 986.476 552.974 552.974 2230.86 2230.86 986.476 552.974 2230.86 4 684352;361921;306575;81639 TWF2_10109;ECT2_8523;CKAP2_8324;ALOX15_8036 236.8682 85.3188 357.7145681822496 132.5866625 53.0023 196.16453459653616 768.917675 187.9351 1267.3444804988458 138.399;10.0162;32.2386;766.819 90.7363;3.29405;15.2683;421.048 299.165;37.7305;76.7052;2662.07 0 Exp 2,1(0.2);Exp 4,2(0.4);Poly 2,1(0.2);Power,1(0.2) 1.7823080590602287 8.972334623336792 1.5021449327468872 2.0582168102264404 0.23192325720918344 1.7946586608886719 -13.31163679262255 786.8911567926225 -5.440275237536838 438.76853523753687 -58.49611514740445 2181.1083951474047 DOWN 0.2 0.8 0.0 GO:0051239 4 regulation of multicellular organismal process 724 769 51 49 32 35 25 25 43 744 1735 0.90655 0.14429 0.23065 3.25 684352;688621;24832;25671;295703;25682;25154;338475;259241;316351;81687;24426;81919;24367;361921;312495;245920;84032;24854;29397;686019;24232;29657;29221;170913 twf2;tslp;thy1;smad1;serping1;ppard;pgr;nrep;nr1d2;npas2;mmp9;gstp1;fut1;fgg;ect2;cyp26b1;cxcl10;col3a1;clu;ccl11;casq1;c3;arntl;arg1;abcb1a TWF2_10109;TSLP_32811;THY1_33010;SMAD1_32578;SERPING1_32597;PPARD_9536;PGR_32824;NREP_9364;NR1D2_9358;NPAS2_9350;MMP9_32531;GSTP1_8762;FUT1_8668;FGG_8639;ECT2_8523;CYP26B1_8418;CXCL10_8408;COL3A1_8354;CLU_32773;CCL11_33230;CASQ1_32992;C3_8175;ARNTL_8086;ARG1_33267;ABCB1A_7938 250.4040840000002 138.399 5.72311E-12 309.5625964759747 256.77538225899696 308.0885444012205 150.43534000000022 78.9726 5.72311E-12 209.40487152544466 153.3340586853643 205.82693805374552 724.1202720000001 285.773 5.72313E-12 836.3055974296116 730.6065542180568 838.5603038776138 138.399;344.675;5.72311E-12;21.9973;32.3997;94.1074;283.618;61.543;29.1728;21.0878;728.316;14.7631;240.861;42.4612;10.0162;18.1872;670.528;212.603;935.649;986.476;147.66;234.759;22.9134;760.927;206.982 90.7363;244.2;5.72311E-12;5.02186;13.7308;37.7692;138.711;25.6719;3.35457;11.3305;443.137;9.42992;78.9726;20.6424;3.29405;10.0176;374.802;119.81;808.484;552.974;96.6023;129.148;11.4115;413.607;118.025 299.165;560.435;5.72313E-12;80.1461;99.4885;148.485;1554.21;148.788;114.038;43.5624;2039.06;25.7196;847.87;98.0534;37.7305;36.7271;1955.3;1510.69;1071.05;2230.86;285.773;694.216;50.1592;2639.93;1531.55 4 21 4 259241;24426;312495;29397 NR1D2_9358;GSTP1_8762;CYP26B1_8418;CCL11_33230 262.149775 23.68 482.92327067250466 143.94402250000002 9.723759999999999 272.70328629173093 601.836175 75.38255 1086.726622567063 29.1728;14.7631;18.1872;986.476 3.35457;9.42992;10.0176;552.974 114.038;25.7196;36.7271;2230.86 21 684352;688621;24832;25671;295703;25682;25154;338475;316351;81687;81919;24367;361921;245920;84032;24854;686019;24232;29657;29221;170913 TWF2_10109;TSLP_32811;THY1_33010;SMAD1_32578;SERPING1_32597;PPARD_9536;PGR_32824;NREP_9364;NPAS2_9350;MMP9_32531;FUT1_8668;FGG_8639;ECT2_8523;CXCL10_8408;COL3A1_8354;CLU_32773;CASQ1_32992;C3_8175;ARNTL_8086;ARG1_33267;ABCB1A_7938 248.1668095238098 147.66 282.80686102432657 151.6717814285717 90.7363 203.605955811232 747.4124809523812 299.165 811.5306010850856 138.399;344.675;5.72311E-12;21.9973;32.3997;94.1074;283.618;61.543;21.0878;728.316;240.861;42.4612;10.0162;670.528;212.603;935.649;147.66;234.759;22.9134;760.927;206.982 90.7363;244.2;5.72311E-12;5.02186;13.7308;37.7692;138.711;25.6719;11.3305;443.137;78.9726;20.6424;3.29405;374.802;119.81;808.484;96.6023;129.148;11.4115;413.607;118.025 299.165;560.435;5.72313E-12;80.1461;99.4885;148.485;1554.21;148.788;43.5624;2039.06;847.87;98.0534;37.7305;1955.3;1510.69;1071.05;285.773;694.216;50.1592;2639.93;1531.55 0 Exp 2,4(0.16);Exp 4,10(0.4);Exp 5,1(0.04);Hill,1(0.04);Linear,1(0.04);Poly 2,7(0.28);Power,1(0.04) 2.0071234368275723 51.869349360466 1.513624906539917 3.5281898975372314 0.5904431040249151 1.863204002380371 129.05554618141815 371.75262181858227 68.34863036202594 232.52204963797456 396.2884778075927 1051.952066192408 DOWN 0.16 0.84 0.0 GO:0048545 5 response to steroid hormone 158 177 15 14 9 11 8 8 60 169 2310 0.95699 0.095803 0.13921 4.52 25154;362282;24426;25315;24232;29221;24646;170913 pgr;pck1;gstp1;ephx1;c3;arg1;abcb1b;abcb1a PGR_32824;PCK1_9439;GSTP1_8762;EPHX1_8567;C3_8175;ARG1_33267;ABCB1B_7939;ABCB1A_7938 261.2906625 220.8705 14.7631 265.52081084016174 220.01102787929204 276.568844029044 149.12702124999998 123.5865 8.25355 156.24687573439454 121.06471926393392 154.5517482951396 950.6992 857.6379999999999 25.7196 928.5104146180698 903.5329404865035 1022.3519417035516 283.618;529.244;14.7631;39.2381;234.759;760.927;20.7941;206.982 138.711;356.883;9.42992;18.9587;129.148;413.607;8.25355;118.025 1554.21;1021.06;25.7196;81.6965;694.216;2639.93;57.2115;1531.55 3 5 3 362282;24426;25315 PCK1_9439;GSTP1_8762;EPHX1_8567 194.4150666666667 39.2381 290.22847440267356 128.42387333333332 18.9587 197.9087639040882 376.15869999999995 81.6965 559.2017689436166 529.244;14.7631;39.2381 356.883;9.42992;18.9587 1021.06;25.7196;81.6965 5 25154;24232;29221;24646;170913 PGR_32824;C3_8175;ARG1_33267;ABCB1B_7939;ABCB1A_7938 301.41602 234.759 275.48898103626937 161.54891000000003 129.148 150.41481640422097 1295.4235 1531.55 977.8858982681721 283.618;234.759;760.927;20.7941;206.982 138.711;129.148;413.607;8.25355;118.025 1554.21;694.216;2639.93;57.2115;1531.55 0 Exp 2,1(0.13);Exp 4,2(0.25);Hill,1(0.13);Linear,1(0.13);Poly 2,3(0.38) 2.16954575426638 19.867488503456116 1.513624906539917 6.191005229949951 1.6409605385342474 1.7494444847106934 77.29412792659562 445.2871970734044 40.85346038641788 257.4005821135821 307.2743096328054 1594.1240903671944 DOWN 0.375 0.625 0.0 GO:0060429 5 epithelium development 39 42 2 2 2 2 2 2 66 40 2439 0.9001 0.30964 0.30964 4.76 25671;288583 smad1;plod3 SMAD1_32578;PLOD3_9507 452.31315 452.31315 21.9973 608.5585111741063 540.5641161456543 595.623199238547 315.34943 315.34943 5.02186 438.8694582722861 378.9927001099278 429.5409989088812 593.08305 593.08305 80.1461 725.4023913322902 698.2782953280658 709.9834857736771 21.9973;882.629 5.02186;625.677 80.1461;1106.02 0 2 0 2 25671;288583 SMAD1_32578;PLOD3_9507 452.31315 452.31315 608.5585111741063 315.34943 315.34943 438.8694582722861 593.08305 593.08305 725.4023913322902 21.9973;882.629 5.02186;625.677 80.1461;1106.02 0 Exp 4,1(0.5);Poly 2,1(0.5) 1.7046038780778765 3.4092843532562256 1.6932154893875122 1.7160688638687134 0.016159776068652945 1.7046421766281128 -391.10591600000004 1295.732216 -292.8926072 923.5914672000001 -412.273372 1598.439472 DOWN 0.0 1.0 0.0 GO:0062197 5 cellular response to chemical stress 112 118 9 9 7 7 6 6 62 112 2367 0.96435 0.092132 0.13014 5.08 24314;81687;361921;114494;29221;170913 nqo1;mmp9;ect2;ccna2;arg1;abcb1a NQO1_33055;MMP9_32531;ECT2_8523;CCNA2_8221;ARG1_33267;ABCB1A_7938 291.05108333333334 116.33165 10.0162 359.16514244566895 280.01713824694883 353.871598222158 165.1157466666667 62.882220000000004 3.29405 208.75175415901595 159.55115727347174 207.18214644323695 1065.4403333333332 808.83555 37.7305 1155.3264829679058 1024.9512913087124 1131.136093915784 4.5 744.6215 25.6813;728.316;10.0162;14.384;760.927;206.982 7.73944;443.137;3.29405;4.89199;413.607;118.025 86.1211;2039.06;37.7305;58.2504;2639.93;1531.55 1 5 1 24314 NQO1_33055 25.6813 25.6813 7.73944 7.73944 86.1211 86.1211 25.6813 7.73944 86.1211 5 81687;361921;114494;29221;170913 MMP9_32531;ECT2_8523;CCNA2_8221;ARG1_33267;ABCB1A_7938 344.12504 206.982 374.33028579465497 196.59100800000002 118.025 216.89035942284426 1261.3041799999999 1531.55 1175.0550006598678 728.316;10.0162;14.384;760.927;206.982 443.137;3.29405;4.89199;413.607;118.025 2039.06;37.7305;58.2504;2639.93;1531.55 0 Exp 2,1(0.17);Exp 4,2(0.34);Hill,1(0.17);Linear,1(0.17);Poly 2,1(0.17) 1.798889215674987 10.887855648994446 1.513624906539917 2.1727771759033203 0.2636149532810828 1.7616559267044067 3.659114753931135 578.4430519127355 -1.9204449961650312 332.15193832949836 140.9866125987544 1989.894054067912 DOWN 0.16666666666666666 0.8333333333333334 0.0 GO:0031669 5 cellular response to nutrient levels 87 92 12 12 8 8 5 5 63 87 2392 0.96591 0.096565 0.096565 5.43 363131;362282;246142;25612;170913 pik3r4;pck1;bmf;asns;abcb1a PIK3R4_9484;PCK1_9439;BMF_8152;ASNS_8091;ABCB1A_7938 400.48 206.982 119.401 348.22316553827955 250.4087872748179 248.80463681926574 281.10572 118.025 81.8286 276.74273300683427 165.98445193986626 195.88959263371393 914.3864 1021.06 220.085 542.6670164541973 789.2710850474851 608.210977533393 3.5 742.436 955.628;529.244;119.401;191.145;206.982 735.228;356.883;81.8286;113.564;118.025 1288.97;1021.06;220.085;510.267;1531.55 1 4 1 362282 PCK1_9439 529.244 529.244 356.883 356.883 1021.06 1021.06 529.244 356.883 1021.06 4 363131;246142;25612;170913 PIK3R4_9484;BMF_8152;ASNS_8091;ABCB1A_7938 368.289 199.0635 393.40915192286354 262.16139999999996 115.7945 315.7891785580585 887.7180000000001 899.6185 622.8231134166424 955.628;119.401;191.145;206.982 735.228;81.8286;113.564;118.025 1288.97;220.085;510.267;1531.55 0 Linear,1(0.2);Poly 2,4(0.8) 1.6759662147736865 8.409521579742432 1.5018656253814697 1.8874764442443848 0.15894544241988118 1.611412525177002 95.24893756236793 705.711062437632 38.53001919331632 523.6814208066836 438.7177875280759 1390.055012471924 DOWN 0.2 0.8 0.0 GO:0072329 7 monocarboxylic acid catabolic process 43 48 5 5 5 5 5 5 63 43 2436 0.99853 0.008227 0.008227 10.42 25682;362282;312495;113902;252898 ppard;pck1;cyp26b1;ces1d;acox2 PPARD_9536;PCK1_9439;CYP26B1_8418;CES1D_32914;ACOX2_32902 279.192 94.1074 11.0684 336.24452273686177 208.71267728946722 320.7415711941337 168.278046 37.7692 4.18343 208.81247214610667 120.51847497053768 194.05182831290026 702.2237 148.485 17.0564 979.112299403383 553.51386891726 968.2407367313026 1.5 56.1473 3.5 636.2985 94.1074;529.244;18.1872;11.0684;743.353 37.7692;356.883;10.0176;4.18343;432.537 148.485;1021.06;36.7271;17.0564;2287.79 2 3 2 362282;312495 PCK1_9439;CYP26B1_8418 273.7156 273.7156 361.3717288514972 183.4503 183.4503 245.27087649898422 528.89355 528.89355 696.0284685350197 529.244;18.1872 356.883;10.0176 1021.06;36.7271 3 25682;113902;252898 PPARD_9536;CES1D_32914;ACOX2_32902 282.8429333333333 94.1074 400.9688391960817 158.16321 37.7692 238.20733293886292 817.7771333333334 148.485 1274.7634056359843 94.1074;11.0684;743.353 37.7692;4.18343;432.537 148.485;17.0564;2287.79 0 Exp 2,1(0.2);Exp 4,1(0.2);Exp 5,2(0.4);Linear,1(0.2) 1.7471140299033412 8.79958164691925 1.5319663286209106 2.090334892272949 0.2412990489058649 1.6269687414169312 -15.539319081425845 573.9233190814259 -14.75415584924255 351.3102478492425 -156.00607035625967 1560.4534703562597 DOWN 0.4 0.6 0.0 GO:0006464 6 cellular protein modification process 420 450 29 29 18 19 13 13 55 437 2042 0.69283 0.42517 0.7473 2.89 315852;24832;25671;291463;288583;363131;362282;362376;81919;84032;297594;114494;29397 ttk;thy1;smad1;ppic;plod3;pik3r4;pck1;herc6;fut1;col3a1;cdca3;ccna2;ccl11 TTK_32727;THY1_33010;SMAD1_32578;PPIC_9541;PLOD3_9507;PIK3R4_9484;PCK1_9439;HERC6_8794;FUT1_8668;COL3A1_8354;CDCA3_8260;CCNA2_8221;CCL11_33230 408.1687692307696 240.861 5.72311E-12 390.22243310880657 323.4485676243564 370.2190048410468 257.9555346153851 119.81 5.72311E-12 269.64672849513227 187.34512800800667 242.0273530993345 928.4452692307697 1021.06 5.72313E-12 789.5113204317389 816.6435671186964 817.7332305664644 737.351;5.72311E-12;21.9973;628.678;882.629;955.628;529.244;39.6865;240.861;212.603;56.6562;14.384;986.476 446.625;5.72311E-12;5.02186;389.239;625.677;735.228;356.883;15.7729;78.9726;119.81;22.3266;4.89199;552.974 2108.09;5.72313E-12;80.1461;1509.86;1106.02;1288.97;1021.06;157.407;847.87;1510.69;150.565;58.2504;2230.86 2 11 2 362282;29397 PCK1_9439;CCL11_33230 757.86 757.86 323.3118477754875 454.9285 454.9285 138.65727582965147 1625.96 1625.96 855.4577838794855 529.244;986.476 356.883;552.974 1021.06;2230.86 11 315852;24832;25671;291463;288583;363131;362376;81919;84032;297594;114494 TTK_32727;THY1_33010;SMAD1_32578;PPIC_9541;PLOD3_9507;PIK3R4_9484;HERC6_8794;FUT1_8668;COL3A1_8354;CDCA3_8260;CCNA2_8221 344.588545454546 212.603 378.64458394920996 222.1422681818187 78.9726 275.9676193601626 801.6244090909096 847.87 748.2083296492709 737.351;5.72311E-12;21.9973;628.678;882.629;955.628;39.6865;240.861;212.603;56.6562;14.384 446.625;5.72311E-12;5.02186;389.239;625.677;735.228;15.7729;78.9726;119.81;22.3266;4.89199 2108.09;5.72313E-12;80.1461;1509.86;1106.02;1288.97;157.407;847.87;1510.69;150.565;58.2504 0 Exp 2,2(0.16);Exp 4,4(0.31);Hill,1(0.08);Linear,2(0.16);Poly 2,3(0.24);Power,1(0.08) 1.800365882464094 23.720432996749878 1.5018656253814697 2.737008571624756 0.33357295276533255 1.7160688638687134 196.04143821816726 620.2961002433722 111.37390327179895 404.53716595897123 499.2620265525549 1357.6285119089846 DOWN 0.15384615384615385 0.8461538461538461 0.0 GO:0045662 7 negative regulation of myoblast differentiation 10 11 2 2 2 2 2 2 66 9 2470 0.99742 0.033069 0.033069 18.18 25682;245920 ppard;cxcl10 PPARD_9536;CXCL10_8408 382.3177 382.3177 94.1074 407.5909150756185 246.58825916542472 359.562778709987 206.28560000000002 206.28560000000002 37.7692 238.31817836228947 126.92467242921013 210.23615409374213 1051.8925 1051.8925 148.485 1277.611138849572 626.4427682563338 1127.064893265239 0.0 94.1074 0.5 382.3177 94.1074;670.528 37.7692;374.802 148.485;1955.3 0 2 0 2 25682;245920 PPARD_9536;CXCL10_8408 382.3177 382.3177 407.5909150756185 206.28560000000002 206.28560000000002 238.31817836228947 1051.8925 1051.8925 1277.611138849572 94.1074;670.528 37.7692;374.802 148.485;1955.3 0 Exp 2,1(0.5);Exp 5,1(0.5) 1.8958746320126976 3.7927039861679077 1.8538048267364502 1.9388991594314575 0.06017077968918382 1.8963519930839539 -182.57448799999992 947.2098879999999 -124.00654399999996 536.5777439999999 -718.7862000000002 2822.5712000000003 DOWN 0.0 1.0 0.0 GO:0010951 8 negative regulation of endopeptidase activity 84 91 7 6 4 4 3 3 65 88 2391 0.77653 0.44142 0.73385 3.3 295703;81687;24232 serping1;mmp9;c3 SERPING1_32597;MMP9_32531;C3_8175 331.8249 234.759 32.3997 357.96817715899 451.4839850603581 380.2025123471524 195.3386 129.148 13.7308 222.22357614771659 270.46323692781334 236.22726427791855 944.2548333333334 694.216 99.4885 993.6669283688991 1273.554436198655 1054.5769596845273 32.3997;728.316;234.759 13.7308;443.137;129.148 99.4885;2039.06;694.216 0 3 0 3 295703;81687;24232 SERPING1_32597;MMP9_32531;C3_8175 331.8249 234.759 357.96817715899 195.3386 129.148 222.22357614771659 944.2548333333334 694.216 993.6669283688991 32.3997;728.316;234.759 13.7308;443.137;129.148 99.4885;2039.06;694.216 0 Exp 4,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 1.7600373447568307 5.3164249658584595 1.5467612743377686 2.05134654045105 0.25656262517223294 1.7183171510696411 -73.25422595036258 736.9040259503624 -56.13104935796437 446.8082493579643 -180.18514908074746 2068.694815747414 DOWN 0.0 1.0 0.0 GO:0061844 5 antimicrobial humoral immune response mediated by antimicrobial peptide 23 27 3 3 3 3 3 3 65 24 2455 0.99487 0.033686 0.033686 11.11 688621;245920;29397 tslp;cxcl10;ccl11 TSLP_32811;CXCL10_8408;CCL11_33230 667.2263333333334 670.528 344.675 320.91323851211445 629.2010187445163 367.40943476367016 390.6586666666667 374.802 244.2 154.9965198878132 378.12316168142297 176.5543107670405 1582.198333333333 1955.3 560.435 895.535348497386 1362.9040137193906 989.6759552040021 0.5 507.6015 1.5 828.502 344.675;670.528;986.476 244.2;374.802;552.974 560.435;1955.3;2230.86 1 2 1 29397 CCL11_33230 986.476 986.476 552.974 552.974 2230.86 2230.86 986.476 552.974 2230.86 2 688621;245920 TSLP_32811;CXCL10_8408 507.6015 507.6015 230.41286596998032 309.501 309.501 92.34955983652573 1257.8674999999998 1257.8674999999998 986.318500339774 344.675;670.528 244.2;374.802 560.435;1955.3 0 Exp 2,2(0.67);Power,1(0.34) 1.8363630009056084 5.521146178245544 1.6858625411987305 1.9814788103103638 0.14826453605900197 1.8538048267364502 304.07881783602477 1030.3738488306417 215.2635930045255 566.0537403288079 568.8046872667032 2595.5919793999633 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0071248 6 cellular response to metal ion 94 103 11 10 6 7 5 5 63 98 2381 0.94556 0.13794 0.19605 4.85 24314;81687;361921;24296;81639 nqo1;mmp9;ect2;cyp1a1;alox15 NQO1_33055;MMP9_32531;ECT2_8523;CYP1A1_8415;ALOX15_8036 308.74376 25.6813 10.0162 400.8640474282185 314.1374983834521 400.0470579915093 176.86997000000002 9.13136 3.29405 233.12604909488408 180.74594528906655 234.97572718653763 968.8610000000001 86.1211 19.3234 1280.6383183961445 973.038535498001 1256.2488006009428 25.6813;728.316;10.0162;12.8863;766.819 7.73944;443.137;3.29405;9.13136;421.048 86.1211;2039.06;37.7305;19.3234;2662.07 2 3 2 24314;24296 NQO1_33055;CYP1A1_8415 19.2838 19.2838 9.047431265281876 8.435400000000001 8.435400000000001 0.9842360708691725 52.72225 52.72225 47.23310663766464 25.6813;12.8863 7.73944;9.13136 86.1211;19.3234 3 81687;361921;81639 MMP9_32531;ECT2_8523;ALOX15_8036 501.71706666666665 728.316 426.2603980700217 289.15968333333336 421.048 247.81313770873973 1579.6201666666668 2039.06 1371.1685429425088 728.316;10.0162;766.819 443.137;3.29405;421.048 2039.06;37.7305;2662.07 0 Exp 2,1(0.2);Exp 4,2(0.4);Hill,1(0.2);Linear,1(0.2) 2.791873694629479 22.849313378334045 1.5021449327468872 15.48720932006836 6.109353654875232 2.05134654045105 -42.629069835796884 660.116589835797 -27.47402169602873 381.2139616960287 -153.66797913372136 2091.389979133721 DOWN 0.4 0.6 0.0 GO:0045892 8 negative regulation of transcription, DNA-templated 221 232 12 10 8 6 5 5 63 227 2252 0.40372 0.75681 0.83017 2.16 25682;25154;259241;25283;29657 ppard;pgr;nr1d2;gclc;arntl PPARD_9536;PGR_32824;NR1D2_9358;GCLC_8699;ARNTL_8086 112.30232000000001 94.1074 22.9134 106.0156632663872 113.97077996493618 83.43301777528703 46.232414 37.7692 3.35457 54.11751109871444 41.54326472679458 42.8005421127417 452.82024 148.485 50.1592 629.6191847113523 403.4437737313724 489.40264716425884 94.1074;283.618;29.1728;131.7;22.9134 37.7692;138.711;3.35457;39.9158;11.4115 148.485;1554.21;114.038;397.209;50.1592 1 4 1 259241 NR1D2_9358 29.1728 29.1728 3.35457 3.35457 114.038 114.038 29.1728 3.35457 114.038 4 25682;25154;25283;29657 PPARD_9536;PGR_32824;GCLC_8699;ARNTL_8086 133.0847 112.90369999999999 110.02899172787748 56.951875 38.8425 56.02583674064286 537.5158 272.847 693.3528474862998 94.1074;283.618;131.7;22.9134 37.7692;138.711;39.9158;11.4115 148.485;1554.21;397.209;50.1592 0 Exp 4,2(0.4);Exp 5,1(0.2);Hill,1(0.2);Poly 2,1(0.2) 2.1346212089314394 11.079530596733093 1.5405861139297485 3.442979335784912 0.7241906677555445 1.9746891260147095 19.3754939405993 205.2291460594007 -1.2036759672113178 93.66850396721134 -99.06530840541143 1004.7057884054115 DOWN 0.2 0.8 0.0 GO:0051234 3 establishment of localization 596 632 31 31 23 20 15 15 53 617 1862 0.35537 0.74615 0.67086 2.37 313089;294881;170551;89776;25682;363131;293502;24367;24854;170945;113902;29657;81639;24646;170913 slc7a13;slc7a12;slc5a6;slc22a7;ppard;pik3r4;kif22;fgg;clu;chrna2;ces1d;arntl;alox15;abcb1b;abcb1a SLC7A13_32952;SLC7A12_32838;SLC5A6_9881;SLC22A7_9847;PPARD_9536;PIK3R4_9484;KIF22_8963;FGG_8639;CLU_32773;CHRNA2_32401;CES1D_32914;ARNTL_8086;ALOX15_8036;ABCB1B_7939;ABCB1A_7938 256.1524733333333 94.1074 11.0684 343.37512747875417 197.4899503349426 287.15137241226324 177.43071466666666 37.7692 3.12114 268.76871208096986 129.7537862520115 219.39815349711398 574.1647733333334 161.307 17.0564 758.3994331513973 520.539515716727 735.1992843670916 397.931;37.9163;120.077;49.1516;94.1074;955.628;17.3097;42.4612;935.649;163.479;11.0684;22.9134;766.819;20.7941;206.982 280.111;15.3983;82.2177;13.5995;37.7692;735.228;3.12114;20.6424;808.484;101.968;4.18343;11.4115;421.048;8.25355;118.025 668.129;132.15;221.286;161.307;148.485;1288.97;90.6321;98.0534;1071.05;414.362;17.0564;50.1592;2662.07;57.2115;1531.55 0 15 0 15 313089;294881;170551;89776;25682;363131;293502;24367;24854;170945;113902;29657;81639;24646;170913 SLC7A13_32952;SLC7A12_32838;SLC5A6_9881;SLC22A7_9847;PPARD_9536;PIK3R4_9484;KIF22_8963;FGG_8639;CLU_32773;CHRNA2_32401;CES1D_32914;ARNTL_8086;ALOX15_8036;ABCB1B_7939;ABCB1A_7938 256.1524733333333 94.1074 343.37512747875417 177.43071466666666 37.7692 268.76871208096986 574.1647733333334 161.307 758.3994331513973 397.931;37.9163;120.077;49.1516;94.1074;955.628;17.3097;42.4612;935.649;163.479;11.0684;22.9134;766.819;20.7941;206.982 280.111;15.3983;82.2177;13.5995;37.7692;735.228;3.12114;20.6424;808.484;101.968;4.18343;11.4115;421.048;8.25355;118.025 668.129;132.15;221.286;161.307;148.485;1288.97;90.6321;98.0534;1071.05;414.362;17.0564;50.1592;2662.07;57.2115;1531.55 0 Exp 2,2(0.14);Exp 4,3(0.2);Exp 5,2(0.14);Hill,3(0.2);Poly 2,5(0.34) 2.0699789308842913 33.82489621639252 1.5018656253814697 6.191005229949951 1.214217241763127 1.8874764442443848 82.380683036997 429.92426362966967 41.41497987282821 313.44644946050505 190.36170574918174 957.9678409174849 DOWN 0.0 1.0 0.0 GO:0007267 3 cell-cell signaling 69 71 8 8 5 4 3 3 65 68 2411 0.88078 0.29415 0.43663 4.23 24832;25154;170945 thy1;pgr;chrna2 THY1_33010;PGR_32824;CHRNA2_32401 149.03233333333523 163.479 5.72311E-12 142.3598332196708 144.79504822335159 112.52951811916607 80.22633333333525 101.968 5.72311E-12 71.86591982527513 83.88412492949938 59.68689389288683 656.1906666666686 414.362 5.72313E-12 804.8310437857933 507.6411111111124 613.4807868273616 5.72311E-12;283.618;163.479 5.72311E-12;138.711;101.968 5.72313E-12;1554.21;414.362 0 3 0 3 24832;25154;170945 THY1_33010;PGR_32824;CHRNA2_32401 149.03233333333523 163.479 142.3598332196708 80.22633333333525 101.968 71.86591982527513 656.1906666666686 414.362 804.8310437857933 5.72311E-12;283.618;163.479 5.72311E-12;138.711;101.968 5.72313E-12;1554.21;414.362 0 Hill,1(0.34);Poly 2,2(0.67) 1.728341737541555 5.202422738075256 1.5405861139297485 1.863204002380371 0.17070430835655304 1.7986326217651367 -12.06298320775241 310.1276498744229 -1.0976106537627857 161.55027732043328 -254.56139610584614 1566.9427294391833 DOWN 0.0 1.0 0.0 GO:0008283 3 cell population proliferation 139 149 11 11 9 7 7 7 61 142 2337 0.95771 0.099202 0.11488 4.7 25671;25682;291234;24426;24296;24854;170913 smad1;ppard;mki67;gstp1;cyp1a1;clu;abcb1a SMAD1_32578;PPARD_9536;MKI67_9232;GSTP1_8762;CYP1A1_8415;CLU_32773;ABCB1A_7938 186.90231428571428 21.9973 12.8863 337.6285772033297 207.70230287724263 334.1002461525491 142.09826857142858 9.42992 5.02186 296.62082745640726 154.9980896009827 294.67869416519744 421.7790714285714 80.1461 19.3234 616.822475068834 568.5392678366709 693.7017946879487 21.9973;94.1074;21.9311;14.7631;12.8863;935.649;206.982 5.02186;37.7692;6.82654;9.42992;9.13136;808.484;118.025 80.1461;148.485;76.1794;25.7196;19.3234;1071.05;1531.55 2 5 2 24426;24296 GSTP1_8762;CYP1A1_8415 13.8247 13.8247 1.3270980069309275 9.28064 9.28064 0.2111138005910525 22.5215 22.5215 4.522796393825391 14.7631;12.8863 9.42992;9.13136 25.7196;19.3234 5 25671;25682;291234;24854;170913 SMAD1_32578;PPARD_9536;MKI67_9232;CLU_32773;ABCB1A_7938 256.13336 94.1074 387.3242072507901 195.22532 37.7692 345.87208048292916 581.4821 148.485 677.5804076736058 21.9973;94.1074;21.9311;935.649;206.982 5.02186;37.7692;6.82654;808.484;118.025 80.1461;148.485;76.1794;1071.05;1531.55 0 Exp 4,4(0.58);Exp 5,1(0.15);Poly 2,2(0.29) 2.687224749182877 28.0118910074234 1.5548590421676636 15.48720932006836 5.107304164174621 1.922041654586792 -63.21643593508864 437.0210645065172 -77.6415155054903 361.83805264834746 -35.16941276152107 878.7275556186639 DOWN 0.2857142857142857 0.7142857142857143 0.0 GO:0009887 4 animal organ morphogenesis 110 116 6 6 3 4 2 2 66 114 2365 0.39312 0.82554 0.76822 1.72 288583;312495 plod3;cyp26b1 PLOD3_9507;CYP26B1_8418 450.4081 450.4081 18.1872 611.2526587211053 203.5001940356881 501.69989509492325 317.8473 317.8473 10.0176 435.33693664124115 141.998361134197 357.31295778871805 571.37355 571.37355 36.7271 756.1042606646289 265.95464175018327 620.5902303148068 882.629;18.1872 625.677;10.0176 1106.02;36.7271 1 1 1 312495 CYP26B1_8418 18.1872 18.1872 10.0176 10.0176 36.7271 36.7271 18.1872 10.0176 36.7271 1 288583 PLOD3_9507 882.629 882.629 625.677 625.677 1106.02 1106.02 882.629 625.677 1106.02 0 Exp 4,1(0.5);Poly 2,1(0.5) 1.8939795731971265 3.8064037561416626 1.7160688638687134 2.090334892272949 0.26464604665239216 1.9032018780708313 -396.7448639999999 1297.561064 -285.498912 921.193512 -476.5334919999998 1619.2805919999998 CONFLICT 0.5 0.5 0.0 GO:2001234 7 negative regulation of apoptotic signaling pathway 88 93 9 9 7 7 6 6 62 87 2392 0.98916 0.035693 0.035693 6.45 81687;24426;25283;24367;24854;246142 mmp9;gstp1;gclc;fgg;clu;bmf MMP9_32531;GSTP1_8762;GCLC_8699;FGG_8639;CLU_32773;BMF_8152 328.71505 125.5505 14.7631 397.78992795344504 298.12590009860855 362.7119335139603 233.90628666666666 60.87219999999999 9.42992 325.74471486378206 198.31186542566013 286.6066677527794 641.8628333333332 308.647 25.7196 780.9577157815336 648.1648865125452 787.8403097373424 3.5 430.00800000000004 728.316;14.7631;131.7;42.4612;935.649;119.401 443.137;9.42992;39.9158;20.6424;808.484;81.8286 2039.06;25.7196;397.209;98.0534;1071.05;220.085 1 5 1 24426 GSTP1_8762 14.7631 14.7631 9.42992 9.42992 25.7196 25.7196 14.7631 9.42992 25.7196 5 81687;25283;24367;24854;246142 MMP9_32531;GCLC_8699;FGG_8639;CLU_32773;BMF_8152 391.50544 131.7 410.15397767651604 278.80156 81.8286 342.8120947684723 765.0914799999999 397.209 805.2819053621236 728.316;131.7;42.4612;935.649;119.401 443.137;39.9158;20.6424;808.484;81.8286 2039.06;397.209;98.0534;1071.05;220.085 0 Exp 4,2(0.34);Hill,1(0.17);Linear,1(0.17);Poly 2,2(0.34) 2.1558440080711647 13.530108571052551 1.5548590421676636 3.5281898975372314 0.7710280860215603 2.0130178332328796 10.416816220555063 647.0132837794449 -26.743770356057297 494.5563436893906 16.9665146442793 1266.7591520223873 DOWN 0.16666666666666666 0.8333333333333334 0.0 GO:0046483 4 heterocycle metabolic process 413 462 25 25 18 17 13 13 55 449 2030 0.65509 0.46613 0.87306 2.81 360243;25682;299112;362282;300795;313108;291234;316273;293502;25315;24296;116599;26760 top2a;ppard;pole2;pck1;pclaf;mms22l;mki67;mcm3;kif22;ephx1;cyp1a1;blvra;akr7a3 TOP2A_10059;PPARD_9536;POLE2_9520;PCK1_9439;NS5ATP9_9367;MMS22L_33129;MKI67_9232;MCM3_9207;KIF22_8963;EPHX1_8567;CYP1A1_8415;BLVRA_8151;AKR7A3_8015 145.07655386704602 86.3883 2.71598E-7 168.68871895727233 90.34267328141978 117.5910702428815 85.33459540550754 26.6888 2.71598E-7 115.8666371628783 50.0941401583644 79.73136996786609 310.25949232858454 216.887 2.71599E-7 317.3117515208422 203.25147547748543 223.1123674910044 86.3883;94.1074;2.71598E-7;529.244;292.216;126.653;21.9311;197.273;17.3097;39.2381;12.8863;415.991;52.7573 26.6888;37.7692;2.71598E-7;356.883;147.515;85.587;6.82654;116.413;3.12114;18.9587;9.13136;288.048;12.408 262.273;148.485;2.71599E-7;1021.06;658.494;240.486;76.1794;496.915;90.6321;81.6965;19.3234;720.942;216.887 4 9 4 362282;25315;24296;26760 PCK1_9439;EPHX1_8567;CYP1A1_8415;AKR7A3_8015 158.531425 45.9977 247.6956321835783 99.345265 15.68335 171.74042572290958 334.741725 149.29175 464.9168801857336 529.244;39.2381;12.8863;52.7573 356.883;18.9587;9.13136;12.408 1021.06;81.6965;19.3234;216.887 9 360243;25682;299112;300795;313108;291234;316273;293502;116599 TOP2A_10059;PPARD_9536;POLE2_9520;NS5ATP9_9367;MMS22L_33129;MKI67_9232;MCM3_9207;KIF22_8963;BLVRA_8151 139.0966111412887 94.1074 139.80578339657131 79.10763114128866 37.7692 94.5267413230745 299.3785000301777 240.486 263.7078811362343 86.3883;94.1074;2.71598E-7;292.216;126.653;21.9311;197.273;17.3097;415.991 26.6888;37.7692;2.71598E-7;147.515;85.587;6.82654;116.413;3.12114;288.048 262.273;148.485;2.71599E-7;658.494;240.486;76.1794;496.915;90.6321;720.942 0 Exp 2,2(0.16);Exp 4,4(0.31);Exp 5,1(0.08);Hill,3(0.24);Linear,1(0.08);Poly 2,2(0.16) 2.050101691240934 36.38327980041504 1.540663719177246 15.48720932006836 3.816693286381297 1.6661498546600342 53.376321670596155 236.77678606349588 22.348773962705636 148.32041684830943 137.76685931206586 482.7521253451033 DOWN 0.3076923076923077 0.6923076923076923 0.0 GO:0044057 5 regulation of system process 160 167 12 10 6 7 4 4 64 163 2316 0.53599 0.66246 1.0 2.4 25154;24367;686019;170913 pgr;fgg;casq1;abcb1a PGR_32824;FGG_8639;CASQ1_32992;ABCB1A_7938 170.1803 177.321 42.4612 101.72153053161036 147.14316426166428 87.34586495297411 93.495175 107.31365 20.6424 51.521400718301855 85.3136050865801 48.25820213839952 867.3966 908.6614999999999 98.0534 783.7915021684274 678.4859942279943 740.900631014995 283.618;42.4612;147.66;206.982 138.711;20.6424;96.6023;118.025 1554.21;98.0534;285.773;1531.55 0 4 0 4 25154;24367;686019;170913 PGR_32824;FGG_8639;CASQ1_32992;ABCB1A_7938 170.1803 177.321 101.72153053161036 93.495175 107.31365 51.521400718301855 867.3966 908.6614999999999 783.7915021684274 283.618;42.4612;147.66;206.982 138.711;20.6424;96.6023;118.025 1554.21;98.0534;285.773;1531.55 0 Exp 4,1(0.25);Poly 2,3(0.75) 2.0896107359530527 8.57276737689972 1.5405861139297485 2.8176381587982178 0.5529351411823076 2.1072715520858765 70.4932000790219 269.86739992097813 43.0042022960642 143.9861477039358 99.2809278749412 1635.5122721250589 DOWN 0.0 1.0 0.0 GO:0009611 4 response to wounding 115 120 16 16 9 13 8 8 60 112 2367 0.99603 0.013203 0.013203 6.67 25671;25682;338475;24296;84032;24854;29221;81639 smad1;ppard;nrep;cyp1a1;col3a1;clu;arg1;alox15 SMAD1_32578;PPARD_9536;NREP_9364;CYP1A1_8415;COL3A1_8354;CLU_32773;ARG1_33267;ALOX15_8036 358.3165 153.3552 12.8863 391.66828768391315 431.170981712338 397.0019936306543 230.06791500000003 78.78960000000001 5.02186 291.5714023653264 271.94599359071276 291.10989483801563 1035.0603125 609.919 19.3234 1131.709397302593 1240.7492314423596 1199.7428119895444 5.0 760.927 21.9973;94.1074;61.543;12.8863;212.603;935.649;760.927;766.819 5.02186;37.7692;25.6719;9.13136;119.81;808.484;413.607;421.048 80.1461;148.485;148.788;19.3234;1510.69;1071.05;2639.93;2662.07 1 7 1 24296 CYP1A1_8415 12.8863 12.8863 9.13136 9.13136 19.3234 19.3234 12.8863 9.13136 19.3234 7 25671;25682;338475;84032;24854;29221;81639 SMAD1_32578;PPARD_9536;NREP_9364;COL3A1_8354;CLU_32773;ARG1_33267;ALOX15_8036 407.66367142857143 212.603 395.27633934432373 261.63027999999997 119.81 299.80853257119537 1180.1655857142855 1071.05 1139.1702288642534 21.9973;94.1074;61.543;212.603;935.649;760.927;766.819 5.02186;37.7692;25.6719;119.81;808.484;413.607;421.048 80.1461;148.485;148.788;1510.69;1071.05;2639.93;2662.07 0 Exp 2,2(0.25);Exp 4,3(0.38);Exp 5,1(0.13);Poly 2,2(0.25) 2.1841527376887995 27.08931005001068 1.5021449327468872 15.48720932006836 4.89181610692054 1.6531004905700684 86.90422384692187 629.7287761530781 28.019241503658236 432.1165884963418 250.8257111181 1819.2949138819 DOWN 0.125 0.875 0.0 GO:0016192 4 vesicle-mediated transport 163 173 5 5 4 2 2 2 66 171 2308 0.14748 0.95223 0.32268 1.16 363131;81639 pik3r4;alox15 PIK3R4_9484;ALOX15_8036 861.2235000000001 861.2235000000001 766.819 133.50812424905027 817.2582517911975 118.14623625142227 578.1379999999999 578.1379999999999 421.048 222.15880851318997 504.9794022517912 196.59647848074883 1975.52 1975.52 1288.97 970.9283212472492 2295.254135107472 859.2100853075195 955.628;766.819 735.228;421.048 1288.97;2662.07 0 2 0 2 363131;81639 PIK3R4_9484;ALOX15_8036 861.2235000000001 861.2235000000001 133.50812424905027 578.1379999999999 578.1379999999999 222.15880851318997 1975.52 1975.52 970.9283212472492 955.628;766.819 735.228;421.048 1288.97;2662.07 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.5020052725718074 3.004010558128357 1.5018656253814697 1.5021449327468872 1.9750013212204944E-4 1.5020052790641785 676.19068 1046.25632 270.24159999999995 886.0343999999999 629.8819999999998 3321.1580000000004 DOWN 0.0 1.0 0.0 GO:0045765 6 regulation of angiogenesis 105 108 12 12 7 10 6 6 62 102 2377 0.97673 0.065716 0.065716 5.56 25671;81687;81919;245920;29397;24232 smad1;mmp9;fut1;cxcl10;ccl11;c3 SMAD1_32578;MMP9_32531;FUT1_8668;CXCL10_8408;CCL11_33230;C3_8175 480.48955 455.6945 21.9973 369.2087046292584 534.9822551110931 347.95323777063413 264.00924333333336 251.97500000000002 5.02186 222.42436817443564 290.53039700577847 222.71111266031943 1307.9086833333333 1401.585 80.1461 883.3110616842525 1458.8360574468952 768.8221816874706 4.5 857.396 21.9973;728.316;240.861;670.528;986.476;234.759 5.02186;443.137;78.9726;374.802;552.974;129.148 80.1461;2039.06;847.87;1955.3;2230.86;694.216 1 5 1 29397 CCL11_33230 986.476 986.476 552.974 552.974 2230.86 2230.86 986.476 552.974 2230.86 5 25671;81687;81919;245920;24232 SMAD1_32578;MMP9_32531;FUT1_8668;CXCL10_8408;C3_8175 379.29226000000006 240.861 305.9201663709635 206.216292 129.148 191.8086553537622 1123.31842 847.87 848.3786299384147 21.9973;728.316;240.861;670.528;234.759 5.02186;443.137;78.9726;374.802;129.148 80.1461;2039.06;847.87;1955.3;694.216 0 Exp 2,2(0.34);Exp 4,1(0.17);Linear,1(0.17);Poly 2,1(0.17);Power,1(0.17) 1.9442436646167593 11.8636155128479 1.5467612743377686 2.737008571624756 0.41568644962762735 1.917641818523407 185.06105792102665 775.9180420789734 86.03268192648568 441.98580474018104 601.1126308077176 2014.7047358589487 DOWN 0.16666666666666666 0.8333333333333334 0.0 GO:0048771 3 tissue remodeling 36 39 5 5 3 4 3 3 65 36 2443 0.98107 0.08408 0.08408 7.69 81687;29221;24646 mmp9;arg1;abcb1b MMP9_32531;ARG1_33267;ABCB1B_7939 503.3457 728.316 20.7941 418.2199233981686 419.0889767702262 439.9367693246208 288.33251666666666 413.607 8.25355 243.00447712295517 241.01995995594507 257.30398634510686 1578.733833333333 2039.06 57.2115 1351.493191750918 1296.712763618007 1394.9745990792867 0.5 374.55505 728.316;760.927;20.7941 443.137;413.607;8.25355 2039.06;2639.93;57.2115 0 3 0 3 81687;29221;24646 MMP9_32531;ARG1_33267;ABCB1B_7939 503.3457 728.316 418.2199233981686 288.33251666666666 413.607 243.00447712295517 1578.733833333333 2039.06 1351.493191750918 728.316;760.927;20.7941 443.137;413.607;8.25355 2039.06;2639.93;57.2115 0 Exp 2,1(0.34);Hill,1(0.34);Linear,1(0.34) 2.678795062983761 9.755976676940918 1.513624906539917 6.191005229949951 2.5594206802498354 2.05134654045105 30.085304705381247 976.6060952946186 13.3470641154708 563.3179692178626 49.37531552526889 3108.0923511413976 DOWN 0.0 1.0 0.0 GO:0072347 5 response to anesthetic 42 44 3 3 3 3 3 3 65 41 2438 0.97172 0.11108 0.11108 6.82 25154;114494;170913 pgr;ccna2;abcb1a PGR_32824;CCNA2_8221;ABCB1A_7938 168.328 206.982 14.384 138.71674547797036 144.08174435057353 131.58055636445349 87.20933000000001 118.025 4.89199 72.03531076844676 77.08636039219728 71.51484924553705 1048.0034666666668 1531.55 58.2504 857.2261770571716 957.9486442750191 884.5577131669565 1.5 245.3 283.618;14.384;206.982 138.711;4.89199;118.025 1554.21;58.2504;1531.55 0 3 0 3 25154;114494;170913 PGR_32824;CCNA2_8221;ABCB1A_7938 168.328 206.982 138.71674547797036 87.20933000000001 118.025 72.03531076844676 1048.0034666666668 1531.55 857.2261770571716 283.618;14.384;206.982 138.711;4.89199;118.025 1554.21;58.2504;1531.55 0 Exp 4,1(0.34);Poly 2,2(0.67) 1.6786756782277357 5.0548577308654785 1.5405861139297485 1.8874764442443848 0.18060990579001449 1.6267951726913452 11.355225328082668 325.30077467191734 5.693702115890673 168.72495788410936 77.96072906917698 2018.0462042641561 DOWN 0.0 1.0 0.0 GO:0051173 6 positive regulation of nitrogen compound metabolic process 649 698 40 39 27 25 20 20 48 678 1801 0.70124 0.39872 0.68141 2.87 688621;360243;24832;25671;25682;25154;362282;259241;316351;81687;25283;24367;361921;24854;306575;114494;29397;24232;29657;81639 tslp;top2a;thy1;smad1;ppard;pgr;pck1;nr1d2;npas2;mmp9;gclc;fgg;ect2;clu;ckap2;ccna2;ccl11;c3;arntl;alox15 TSLP_32811;TOP2A_10059;THY1_33010;SMAD1_32578;PPARD_9536;PGR_32824;PCK1_9439;NR1D2_9358;NPAS2_9350;MMP9_32531;GCLC_8699;FGG_8639;ECT2_8523;CLU_32773;CKAP2_8324;CCNA2_8221;CCL11_33230;C3_8175;ARNTL_8086;ALOX15_8036 265.8011500000003 90.24785 5.72311E-12 334.63206118413945 255.77474113082755 333.9028945079288 163.70869850000028 32.229 5.72311E-12 232.2326315760372 153.61608938964736 226.35715183923662 659.9786600000003 205.37900000000002 5.72313E-12 833.6272083657153 639.4937480228896 850.4772321508618 344.675;86.3883;5.72311E-12;21.9973;94.1074;283.618;529.244;29.1728;21.0878;728.316;131.7;42.4612;10.0162;935.649;32.2386;14.384;986.476;234.759;22.9134;766.819 244.2;26.6888;5.72311E-12;5.02186;37.7692;138.711;356.883;3.35457;11.3305;443.137;39.9158;20.6424;3.29405;808.484;15.2683;4.89199;552.974;129.148;11.4115;421.048 560.435;262.273;5.72313E-12;80.1461;148.485;1554.21;1021.06;114.038;43.5624;2039.06;397.209;98.0534;37.7305;1071.05;76.7052;58.2504;2230.86;694.216;50.1592;2662.07 3 17 3 362282;259241;29397 PCK1_9439;NR1D2_9358;CCL11_33230 514.9642666666667 529.244 478.81132742512824 304.4038566666667 356.883 278.5425009260376 1121.986 1021.06 1062.0138360812443 529.244;29.1728;986.476 356.883;3.35457;552.974 1021.06;114.038;2230.86 17 688621;360243;24832;25671;25682;25154;316351;81687;25283;24367;361921;24854;306575;114494;24232;29657;81639 TSLP_32811;TOP2A_10059;THY1_33010;SMAD1_32578;PPARD_9536;PGR_32824;NPAS2_9350;MMP9_32531;GCLC_8699;FGG_8639;ECT2_8523;CLU_32773;CKAP2_8324;CCNA2_8221;C3_8175;ARNTL_8086;ALOX15_8036 221.83118823529443 86.3883 301.0356376611803 138.88014117647094 26.6888 223.56080025464436 578.4479529411768 148.485 798.2265362209753 344.675;86.3883;5.72311E-12;21.9973;94.1074;283.618;21.0878;728.316;131.7;42.4612;10.0162;935.649;32.2386;14.384;234.759;22.9134;766.819 244.2;26.6888;5.72311E-12;5.02186;37.7692;138.711;11.3305;443.137;39.9158;20.6424;3.29405;808.484;15.2683;4.89199;129.148;11.4115;421.048 560.435;262.273;5.72313E-12;80.1461;148.485;1554.21;43.5624;2039.06;397.209;98.0534;37.7305;1071.05;76.7052;58.2504;694.216;50.1592;2662.07 0 Exp 2,2(0.1);Exp 4,9(0.45);Exp 5,1(0.05);Hill,2(0.1);Linear,2(0.1);Poly 2,3(0.15);Power,1(0.05) 1.9311720741983065 39.753103256225586 1.5021449327468872 3.442979335784912 0.536373164053828 1.9010515809059143 119.14218289331376 412.4601171066867 61.928260143654384 265.48913685634625 294.62542726337267 1025.331892736628 DOWN 0.15 0.85 0.0 GO:0065009 3 regulation of molecular function 643 686 40 38 23 21 14 14 54 672 1807 0.14451 0.91203 0.26873 2.04 24832;295703;363131;304545;24314;81687;24426;361921;24854;114494;29397;686019;24232;170913 thy1;serping1;pik3r4;oasl;nqo1;mmp9;gstp1;ect2;clu;ccna2;ccl11;casq1;c3;abcb1a THY1_33010;SERPING1_32597;PIK3R4_9484;OASL_9389;NQO1_33055;MMP9_32531;GSTP1_8762;ECT2_8523;CLU_32773;CCNA2_8221;CCL11_33230;CASQ1_32992;C3_8175;ABCB1A_7938 312.09477857142895 112.1363 5.72311E-12 397.73006440480947 286.01941920198027 373.1881040712796 210.79515714285756 62.525 5.72311E-12 292.9157639334288 186.35477977619854 262.9590626962263 693.5127214285719 273.081 5.72313E-12 794.6696536051625 714.042508888688 836.8365585766281 5.72311E-12;32.3997;955.628;76.6126;25.6813;728.316;14.7631;10.0162;935.649;14.384;986.476;147.66;234.759;206.982 5.72311E-12;13.7308;735.228;28.4477;7.73944;443.137;9.42992;3.29405;808.484;4.89199;552.974;96.6023;129.148;118.025 5.72313E-12;99.4885;1288.97;260.389;86.1211;2039.06;25.7196;37.7305;1071.05;58.2504;2230.86;285.773;694.216;1531.55 3 11 3 24314;24426;29397 NQO1_33055;GSTP1_8762;CCL11_33230 342.3068 25.6813 557.8936013652514 190.04778666666667 9.42992 314.30445697446254 780.9002333333334 86.1211 1256.0651173464707 25.6813;14.7631;986.476 7.73944;9.42992;552.974 86.1211;25.7196;2230.86 11 24832;295703;363131;304545;81687;361921;24854;114494;686019;24232;170913 THY1_33010;SERPING1_32597;PIK3R4_9484;OASL_9389;MMP9_32531;ECT2_8523;CLU_32773;CCNA2_8221;CASQ1_32992;C3_8175;ABCB1A_7938 303.8551363636369 147.66 378.2173985108409 216.4535309090914 96.6023 302.6841999949188 669.6797636363641 285.773 708.8681936935834 5.72311E-12;32.3997;955.628;76.6126;728.316;10.0162;935.649;14.384;147.66;234.759;206.982 5.72311E-12;13.7308;735.228;28.4477;443.137;3.29405;808.484;4.89199;96.6023;129.148;118.025 5.72313E-12;99.4885;1288.97;260.389;2039.06;37.7305;1071.05;58.2504;285.773;694.216;1531.55 0 Exp 4,5(0.36);Hill,2(0.15);Linear,1(0.08);Poly 2,5(0.36);Power,1(0.08) 1.8996903531015912 27.28871715068817 1.5018656253814697 3.5281898975372314 0.5177515134430207 1.875340223312378 103.75102989230265 520.4385272505552 57.3564966874911 364.23381759822405 277.23930030461355 1109.7861425525302 DOWN 0.21428571428571427 0.7857142857142857 0.0 GO:0043508 10 negative regulation of JUN kinase activity 1 1 1 1 1 1 1 1 67 0 2479 1.0 0.026698 0.026698 100.0 24426 gstp1 GSTP1_8762 14.7631 14.7631 14.7631 14.763100000000001 9.42992 9.42992 9.42992 9.42992 25.7196 25.7196 25.7196 25.7196 0.0 14.7631 0.0 14.7631 14.7631 9.42992 25.7196 1 0 1 24426 GSTP1_8762 14.7631 14.7631 9.42992 9.42992 25.7196 25.7196 14.7631 9.42992 25.7196 0 0 Exp 4,1(1) 3.528189897537231 3.5281898975372314 3.5281898975372314 3.5281898975372314 0.0 3.5281898975372314 14.7631 14.7631 9.42992 9.42992 25.7196 25.7196 UP 1.0 0.0 0.0 GO:0007568 3 aging 181 193 18 18 13 14 10 10 58 183 2296 0.98822 0.029784 0.034154 5.18 360243;295703;362282;24314;81687;25283;24296;24854;29657;29221 top2a;serping1;pck1;nqo1;mmp9;gclc;cyp1a1;clu;arntl;arg1 TOP2A_10059;SERPING1_32597;PCK1_9439;NQO1_33055;MMP9_32531;GCLC_8699;CYP1A1_8415;CLU_32773;ARNTL_8086;ARG1_33267 326.6105 109.04415 12.8863 369.00110652550444 318.50674830831747 362.65838682652884 213.07287000000002 33.3023 7.73944 278.33236065010965 195.8189502392404 267.2708353904454 768.56742 329.741 19.3234 922.3469571686915 820.3750424040134 961.3285938989976 8.5 848.288 86.3883;32.3997;529.244;25.6813;728.316;131.7;12.8863;935.649;22.9134;760.927 26.6888;13.7308;356.883;7.73944;443.137;39.9158;9.13136;808.484;11.4115;413.607 262.273;99.4885;1021.06;86.1211;2039.06;397.209;19.3234;1071.05;50.1592;2639.93 3 7 3 362282;24314;24296 PCK1_9439;NQO1_33055;CYP1A1_8415 189.27053333333333 25.6813 294.49515536637165 124.58459999999998 9.13136 201.1775194753171 375.5015 86.1211 560.0667959029618 529.244;25.6813;12.8863 356.883;7.73944;9.13136 1021.06;86.1211;19.3234 7 360243;295703;81687;25283;24854;29657;29221 TOP2A_10059;SERPING1_32597;MMP9_32531;GCLC_8699;CLU_32773;ARNTL_8086;ARG1_33267 385.4704857142857 131.7 402.3189596420748 250.9964142857143 39.9158 311.64013699564026 937.0242428571429 397.209 1030.1309942812188 86.3883;32.3997;728.316;131.7;935.649;22.9134;760.927 26.6888;13.7308;443.137;39.9158;808.484;11.4115;413.607 262.273;99.4885;2039.06;397.209;1071.05;50.1592;2639.93 0 Exp 2,1(0.1);Exp 4,4(0.4);Hill,2(0.2);Linear,2(0.2);Poly 2,1(0.1) 2.3866075400490194 33.48754966259003 1.513624906539917 15.48720932006836 4.3011027537189905 1.9675118327140808 97.90124467436908 555.3197553256309 40.56068558758906 385.58505441241095 196.89085319454864 1340.2439868054516 DOWN 0.3 0.7 0.0 GO:0008104 4 protein localization 289 309 17 16 12 12 8 8 60 301 2178 0.55535 0.59452 1.0 2.59 315852;24832;288583;363131;24367;24854;29657;170913 ttk;thy1;plod3;pik3r4;fgg;clu;arntl;abcb1a TTK_32727;THY1_33010;PLOD3_9507;PIK3R4_9484;FGG_8639;CLU_32773;ARNTL_8086;ABCB1A_7938 472.95170000000076 472.1665 5.72311E-12 441.925561911065 392.48818909252316 412.5646380707187 345.7616125000007 282.325 5.72311E-12 347.07547129040665 282.1975045390949 328.54724704509914 906.7365750000008 1088.5349999999999 5.72313E-12 779.7730015344523 935.1579473669847 808.3446016429061 737.351;5.72311E-12;882.629;955.628;42.4612;935.649;22.9134;206.982 446.625;5.72311E-12;625.677;735.228;20.6424;808.484;11.4115;118.025 2108.09;5.72313E-12;1106.02;1288.97;98.0534;1071.05;50.1592;1531.55 0 8 0 8 315852;24832;288583;363131;24367;24854;29657;170913 TTK_32727;THY1_33010;PLOD3_9507;PIK3R4_9484;FGG_8639;CLU_32773;ARNTL_8086;ABCB1A_7938 472.95170000000076 472.1665 441.925561911065 345.7616125000007 282.325 347.07547129040665 906.7365750000008 1088.5349999999999 779.7730015344523 737.351;5.72311E-12;882.629;955.628;42.4612;935.649;22.9134;206.982 446.625;5.72311E-12;625.677;735.228;20.6424;808.484;11.4115;118.025 2108.09;5.72313E-12;1106.02;1288.97;98.0534;1071.05;50.1592;1531.55 0 Exp 4,2(0.25);Hill,1(0.13);Linear,1(0.13);Poly 2,4(0.5) 1.9471118930098417 16.29524600505829 1.5018656253814697 3.442979335784912 0.7108420611293645 1.7896364331245422 166.71290962515093 779.1904903748505 105.25058155369658 586.2726434463048 366.3814533722252 1447.0916966277762 DOWN 0.0 1.0 0.0 GO:0032102 6 negative regulation of response to external stimulus 106 114 11 11 6 9 6 6 62 108 2371 0.96974 0.08095 0.12353 5.26 295703;25682;259241;24426;24367;29221 serping1;ppard;nr1d2;gstp1;fgg;arg1 SERPING1_32597;PPARD_9536;NR1D2_9358;GSTP1_8762;FGG_8639;ARG1_33267 162.3052 37.43045 14.7631 294.5267151986386 185.1540760886571 313.6831570498785 83.08898166666667 17.1866 3.35457 162.3511070172971 95.71667790501026 172.99928186133863 520.9524166666666 106.76325 25.7196 1038.8559353146063 601.148697478115 1107.7479668209805 4.5 427.5172 32.3997;94.1074;29.1728;14.7631;42.4612;760.927 13.7308;37.7692;3.35457;9.42992;20.6424;413.607 99.4885;148.485;114.038;25.7196;98.0534;2639.93 2 4 2 259241;24426 NR1D2_9358;GSTP1_8762 21.96795 21.96795 10.18919658486379 6.392244999999999 6.392244999999999 4.295921183081692 69.8788 69.8788 62.45053954354597 29.1728;14.7631 3.35457;9.42992 114.038;25.7196 4 295703;25682;24367;29221 SERPING1_32597;PPARD_9536;FGG_8639;ARG1_33267 232.473825 68.2843 353.3376472482412 121.43735000000001 29.205799999999996 195.041693460612 746.4892249999999 123.98675 1262.511515306482 32.3997;94.1074;42.4612;760.927 13.7308;37.7692;20.6424;413.607 99.4885;148.485;98.0534;2639.93 0 Exp 2,1(0.17);Exp 4,4(0.67);Exp 5,1(0.17) 2.186958904644006 13.69904613494873 1.513624906539917 3.5281898975372314 0.7583760041235548 2.0606380105018616 -73.36525483253132 397.97565483253135 -46.81895964699869 212.99692298033204 -310.30545620896737 1352.2102895423006 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0045597 6 positive regulation of cell differentiation 285 303 19 17 11 9 7 7 61 296 2183 0.429 0.71663 0.84951 2.31 684352;25671;361921;312495;24854;29657;170913 twf2;smad1;ect2;cyp26b1;clu;arntl;abcb1a TWF2_10109;SMAD1_32578;ECT2_8523;CYP26B1_8418;CLU_32773;ARNTL_8086;ABCB1A_7938 193.44915714285713 22.9134 10.0162 335.8861045910645 197.02705235107533 327.68096056657623 149.57004428571432 11.4115 3.29405 294.24411987060125 150.0105736107916 286.5849755907475 443.7897 80.1461 36.7271 607.6402349302971 545.2961469308794 681.3753522939512 138.399;21.9973;10.0162;18.1872;935.649;22.9134;206.982 90.7363;5.02186;3.29405;10.0176;808.484;11.4115;118.025 299.165;80.1461;37.7305;36.7271;1071.05;50.1592;1531.55 1 6 1 312495 CYP26B1_8418 18.1872 18.1872 10.0176 10.0176 36.7271 36.7271 18.1872 10.0176 36.7271 6 684352;25671;361921;24854;29657;170913 TWF2_10109;SMAD1_32578;ECT2_8523;CLU_32773;ARNTL_8086;ABCB1A_7938 222.65948333333336 80.6562 358.0727967845891 172.828785 51.0739 315.2005436691837 511.63346666666666 189.65555 635.9313343852452 138.399;21.9973;10.0162;935.649;22.9134;206.982 90.7363;5.02186;3.29405;808.484;11.4115;118.025 299.165;80.1461;37.7305;1071.05;50.1592;1531.55 0 Exp 4,4(0.58);Poly 2,3(0.43) 1.9441807983019626 14.099359273910522 1.5548590421676636 3.442979335784912 0.6542997664559954 1.7946586608886719 -55.37875130239519 442.27706558810945 -68.40905017207882 367.5491387435074 -6.356485502280236 893.9358855022801 DOWN 0.14285714285714285 0.8571428571428571 0.0 GO:0065008 3 regulation of biological quality 821 880 59 57 39 40 30 30 38 850 1629 0.96314 0.062017 0.094571 3.41 116669;286989;684352;24832;25671;295703;25682;288583;362282;259241;24314;81687;25283;24367;29243;64191;312495;24296;245920;24854;170945;113902;29397;686019;24232;29657;81639;252898;24646;170913 vwf;ugt2b7;twf2;thy1;smad1;serping1;ppard;plod3;pck1;nr1d2;nqo1;mmp9;gclc;fgg;f10;dhcr7;cyp26b1;cyp1a1;cxcl10;clu;chrna2;ces1d;ccl11;casq1;c3;arntl;alox15;acox2;abcb1b;abcb1a VWF_32396;UGT2B7_33032;TWF2_10109;THY1_33010;SMAD1_32578;SERPING1_32597;PPARD_9536;PLOD3_9507;PCK1_9439;NR1D2_9358;NQO1_33055;MMP9_32531;GCLC_8699;FGG_8639;F10_8585;DHCR7_8466;CYP26B1_8418;CYP1A1_8415;CXCL10_8408;CLU_32773;CHRNA2_32401;CES1D_32914;CCL11_33230;CASQ1_32992;C3_8175;ARNTL_8086;ALOX15_8036;ACOX2_32902;ABCB1B_7939;ABCB1A_7938 263.93143666666685 117.945 5.72311E-12 330.90298486499694 220.44318948620818 299.53955486747185 161.04713500000022 39.169349999999994 5.72311E-12 225.0210922174339 129.06487527395055 200.44001202827712 654.8652566666667 224.4085 5.72313E-12 820.1888920753534 589.8745271692237 783.6042141827074 19.6764;34.7126;138.399;5.72311E-12;21.9973;32.3997;94.1074;882.629;529.244;29.1728;25.6813;728.316;131.7;42.4612;104.19;161.702;18.1872;12.8863;670.528;935.649;163.479;11.0684;986.476;147.66;234.759;22.9134;766.819;743.353;20.7941;206.982 4.11644;14.7729;90.7363;5.72311E-12;5.02186;13.7308;37.7692;625.677;356.883;3.35457;7.73944;443.137;39.9158;20.6424;38.4229;50.9087;10.0176;9.13136;374.802;808.484;101.968;4.18343;552.974;96.6023;129.148;11.4115;421.048;432.537;8.25355;118.025 94.078;105.024;299.165;5.72313E-12;80.1461;99.4885;148.485;1106.02;1021.06;114.038;86.1211;2039.06;397.209;98.0534;163.044;481.517;36.7271;19.3234;1955.3;1071.05;414.362;17.0564;2230.86;285.773;694.216;50.1592;2662.07;2287.79;57.2115;1531.55 7 23 7 286989;362282;259241;24314;312495;24296;29397 UGT2B7_33032;PCK1_9439;NR1D2_9358;NQO1_33055;CYP26B1_8418;CYP1A1_8415;CCL11_33230 233.76574285714287 29.1728 381.6458937673676 136.41041 10.0176 224.85708252185484 516.1648 105.024 835.4131693792699 34.7126;529.244;29.1728;25.6813;18.1872;12.8863;986.476 14.7729;356.883;3.35457;7.73944;10.0176;9.13136;552.974 105.024;1021.06;114.038;86.1211;36.7271;19.3234;2230.86 23 116669;684352;24832;25671;295703;25682;288583;81687;25283;24367;29243;64191;245920;24854;170945;113902;686019;24232;29657;81639;252898;24646;170913 VWF_32396;TWF2_10109;THY1_33010;SMAD1_32578;SERPING1_32597;PPARD_9536;PLOD3_9507;MMP9_32531;GCLC_8699;FGG_8639;F10_8585;DHCR7_8466;CXCL10_8408;CLU_32773;CHRNA2_32401;CES1D_32914;CASQ1_32992;C3_8175;ARNTL_8086;ALOX15_8036;ACOX2_32902;ABCB1B_7939;ABCB1A_7938 273.1123000000003 138.399 322.8549374255196 168.54526869565242 50.9087 229.57412520909313 697.078439130435 299.165 829.7163844527025 19.6764;138.399;5.72311E-12;21.9973;32.3997;94.1074;882.629;728.316;131.7;42.4612;104.19;161.702;670.528;935.649;163.479;11.0684;147.66;234.759;22.9134;766.819;743.353;20.7941;206.982 4.11644;90.7363;5.72311E-12;5.02186;13.7308;37.7692;625.677;443.137;39.9158;20.6424;38.4229;50.9087;374.802;808.484;101.968;4.18343;96.6023;129.148;11.4115;421.048;432.537;8.25355;118.025 94.078;299.165;5.72313E-12;80.1461;99.4885;148.485;1106.02;2039.06;397.209;98.0534;163.044;481.517;1955.3;1071.05;414.362;17.0564;285.773;694.216;50.1592;2662.07;2287.79;57.2115;1531.55 0 Exp 2,3(0.1);Exp 4,9(0.3);Exp 5,3(0.1);Hill,5(0.17);Linear,2(0.07);Poly 2,7(0.24);Power,1(0.04) 2.193876545935009 79.69469404220581 1.5021449327468872 15.48720932006836 2.6701222682475887 1.875340223312378 145.51932428451863 382.3435490488152 80.52437129366689 241.5698987063335 361.364431031504 948.3660823018297 DOWN 0.23333333333333334 0.7666666666666667 0.0 GO:0045598 6 regulation of fat cell differentiation 37 42 4 4 4 2 2 2 66 40 2439 0.9001 0.30964 0.30964 4.76 25682;29657 ppard;arntl PPARD_9536;ARNTL_8086 58.5104 58.5104 22.9134 50.34176017979507 77.62897562779831 42.46472594905462 24.59035 24.59035 11.4115 18.63770840648066 31.66849817013821 15.721444323221002 99.3221 99.3221 50.1592 69.52683994559226 125.72670212186101 58.64789379331902 94.1074;22.9134 37.7692;11.4115 148.485;50.1592 0 2 0 2 25682;29657 PPARD_9536;ARNTL_8086 58.5104 58.5104 50.34176017979507 24.59035 24.59035 18.63770840648066 99.3221 99.3221 69.52683994559226 94.1074;22.9134 37.7692;11.4115 148.485;50.1592 0 Exp 4,1(0.5);Exp 5,1(0.5) 2.5837162654001395 5.38187849521637 1.9388991594314575 3.442979335784912 1.063545292147786 2.690939247608185 -11.259719999999994 128.28052 -1.2401959999999939 50.420896 2.962816000000018 195.68138399999998 DOWN 0.0 1.0 0.0 GO:0001558 5 regulation of cell growth 111 120 6 5 2 3 2 2 66 118 2361 0.36972 0.83993 0.76958 1.67 684352;25682 twf2;ppard TWF2_10109;PPARD_9536 116.25319999999999 116.25319999999999 94.1074 31.318890709602154 113.66586891089109 31.104410474250436 64.25274999999999 64.25274999999999 37.7692 37.453395589785984 61.158632277227724 37.19690460562885 223.82500000000002 223.82500000000002 148.485 106.54684978918903 215.02290099009903 105.81718814086774 138.399;94.1074 90.7363;37.7692 299.165;148.485 0 2 0 2 684352;25682 TWF2_10109;PPARD_9536 116.25319999999999 116.25319999999999 31.318890709602154 64.25274999999999 64.25274999999999 37.453395589785984 223.82500000000002 223.82500000000002 106.54684978918903 138.399;94.1074 90.7363;37.7692 299.165;148.485 0 Exp 5,1(0.5);Poly 2,1(0.5) 1.8653852602246623 3.7335578203201294 1.7946586608886719 1.9388991594314575 0.10199343464133205 1.8667789101600647 72.847432 159.658968 12.34499199999999 116.160508 76.15860000000004 371.4914 DOWN 0.0 1.0 0.0 GO:0008284 6 positive regulation of cell population proliferation 272 293 24 23 13 15 9 9 59 284 2195 0.74973 0.38037 0.56806 3.07 688621;25682;25154;81687;245920;24854;114494;29397;29221 tslp;ppard;pgr;mmp9;cxcl10;clu;ccna2;ccl11;arg1 TSLP_32811;PPARD_9536;PGR_32824;MMP9_32531;CXCL10_8408;CLU_32773;CCNA2_8221;CCL11_33230;ARG1_33267 535.4089333333334 670.528 14.384 359.8566447989254 533.2473152148149 367.1052837039314 335.39735444444443 374.802 4.89199 258.6616203157152 335.1238996925926 254.5047887140866 1361.9533777777779 1554.21 58.2504 944.3862166168744 1323.2239077037036 997.0429548971731 344.675;94.1074;283.618;728.316;670.528;935.649;14.384;986.476;760.927 244.2;37.7692;138.711;443.137;374.802;808.484;4.89199;552.974;413.607 560.435;148.485;1554.21;2039.06;1955.3;1071.05;58.2504;2230.86;2639.93 1 8 1 29397 CCL11_33230 986.476 986.476 552.974 552.974 2230.86 2230.86 986.476 552.974 2230.86 8 688621;25682;25154;81687;245920;24854;114494;29221 TSLP_32811;PPARD_9536;PGR_32824;MMP9_32531;CXCL10_8408;CLU_32773;CCNA2_8221;ARG1_33267 479.02555 507.6015 339.55438287078977 308.20027375 309.501 262.4036215770334 1253.34005 1312.63 947.5946278550414 344.675;94.1074;283.618;728.316;670.528;935.649;14.384;760.927 244.2;37.7692;138.711;443.137;374.802;808.484;4.89199;413.607 560.435;148.485;1554.21;2039.06;1955.3;1071.05;58.2504;2639.93 0 Exp 2,3(0.34);Exp 4,1(0.12);Exp 5,1(0.12);Linear,1(0.12);Poly 2,2(0.23);Power,1(0.12) 1.7387783430643329 15.747257113456726 1.513624906539917 2.05134654045105 0.20855157414312248 1.6858625411987305 300.30259206470214 770.5152746019646 166.40509583817726 504.3896130507117 744.9543829214198 1978.9523726341358 DOWN 0.1111111111111111 0.8888888888888888 0.0 GO:0009605 3 response to external stimulus 571 616 50 49 32 33 24 24 44 592 1887 0.98721 0.024592 0.043102 3.9 116669;688621;295703;25682;363131;362282;304545;24314;81687;362376;24426;25283;312495;24296;245920;84032;24854;29397;24232;246142;25612;29221;24646;170913 vwf;tslp;serping1;ppard;pik3r4;pck1;oasl;nqo1;mmp9;herc6;gstp1;gclc;cyp26b1;cyp1a1;cxcl10;col3a1;clu;ccl11;c3;bmf;asns;arg1;abcb1b;abcb1a VWF_32396;TSLP_32811;SERPING1_32597;PPARD_9536;PIK3R4_9484;PCK1_9439;OASL_9389;NQO1_33055;MMP9_32531;HERC6_8794;GSTP1_8762;GCLC_8699;CYP26B1_8418;CYP1A1_8415;CXCL10_8408;COL3A1_8354;CLU_32773;CCL11_33230;C3_8175;BMF_8152;ASNS_8091;ARG1_33267;ABCB1B_7939;ABCB1A_7938 306.7844833333333 161.4225 12.8863 342.1031571237626 254.23223417082883 318.9227005738465 194.83397125000002 97.6963 4.11644 242.54961393203175 156.2323295742333 217.86820139360427 777.3180083333333 453.738 19.3234 815.9713939696991 682.7947769100542 817.11308533644 19.6764;344.675;32.3997;94.1074;955.628;529.244;76.6126;25.6813;728.316;39.6865;14.7631;131.7;18.1872;12.8863;670.528;212.603;935.649;986.476;234.759;119.401;191.145;760.927;20.7941;206.982 4.11644;244.2;13.7308;37.7692;735.228;356.883;28.4477;7.73944;443.137;15.7729;9.42992;39.9158;10.0176;9.13136;374.802;119.81;808.484;552.974;129.148;81.8286;113.564;413.607;8.25355;118.025 94.078;560.435;99.4885;148.485;1288.97;1021.06;260.389;86.1211;2039.06;157.407;25.7196;397.209;36.7271;19.3234;1955.3;1510.69;1071.05;2230.86;694.216;220.085;510.267;2639.93;57.2115;1531.55 6 18 6 362282;24314;24426;312495;24296;29397 PCK1_9439;NQO1_33055;GSTP1_8762;CYP26B1_8418;CYP1A1_8415;CCL11_33230 264.53965 21.93425 408.58807149550876 157.69588666666667 9.723759999999999 238.4409028264289 569.9685333333333 61.424099999999996 903.3178515462243 529.244;25.6813;14.7631;18.1872;12.8863;986.476 356.883;7.73944;9.42992;10.0176;9.13136;552.974 1021.06;86.1211;25.7196;36.7271;19.3234;2230.86 18 116669;688621;295703;25682;363131;304545;81687;362376;25283;245920;84032;24854;24232;246142;25612;29221;24646;170913 VWF_32396;TSLP_32811;SERPING1_32597;PPARD_9536;PIK3R4_9484;OASL_9389;MMP9_32531;HERC6_8794;GCLC_8699;CXCL10_8408;COL3A1_8354;CLU_32773;C3_8175;BMF_8152;ASNS_8091;ARG1_33267;ABCB1B_7939;ABCB1A_7938 320.8660944444444 199.0635 329.2412886188728 207.21333277777777 115.7945 249.44562424230006 846.4344999999998 535.351 800.3583065247936 19.6764;344.675;32.3997;94.1074;955.628;76.6126;728.316;39.6865;131.7;670.528;212.603;935.649;234.759;119.401;191.145;760.927;20.7941;206.982 4.11644;244.2;13.7308;37.7692;735.228;28.4477;443.137;15.7729;39.9158;374.802;119.81;808.484;129.148;81.8286;113.564;413.607;8.25355;118.025 94.078;560.435;99.4885;148.485;1288.97;260.389;2039.06;157.407;397.209;1955.3;1510.69;1071.05;694.216;220.085;510.267;2639.93;57.2115;1531.55 0 Exp 2,3(0.13);Exp 4,6(0.25);Exp 5,1(0.05);Hill,4(0.17);Linear,2(0.09);Poly 2,7(0.3);Power,1(0.05) 2.122830971432121 63.07310092449188 1.5018656253814697 15.48720932006836 2.90463763602568 1.8706406354904175 169.91471485642816 443.6542518102383 97.79391531438651 291.8740271856135 450.8614602108992 1103.7745564557674 DOWN 0.25 0.75 0.0 GO:0015718 8 monocarboxylic acid transport 51 54 4 4 3 3 2 2 66 52 2427 0.82679 0.42605 0.65439 3.7 170551;25682 slc5a6;ppard SLC5A6_9881;PPARD_9536 107.09219999999999 107.09219999999999 94.1074 18.363280264702293 110.32728710536325 17.784220110013923 59.993449999999996 59.993449999999996 37.7692 31.42983576357026 65.53049212628376 30.438740202388743 184.8855 184.8855 148.485 51.478080777161814 193.95447204260174 49.85479207339089 120.077;94.1074 82.2177;37.7692 221.286;148.485 0 2 0 2 170551;25682 SLC5A6_9881;PPARD_9536 107.09219999999999 107.09219999999999 18.363280264702293 59.993449999999996 59.993449999999996 31.42983576357026 184.8855 184.8855 51.478080777161814 120.077;94.1074 82.2177;37.7692 221.286;148.485 0 Exp 5,1(0.5);Poly 2,1(0.5) 1.7154012059210113 3.4565651416778564 1.517665982246399 1.9388991594314575 0.2978568360483094 1.7282825708389282 81.64199199999999 132.542408 16.433920000000008 103.55297999999999 113.54052000000003 256.23048 DOWN 0.0 1.0 0.0 GO:0042752 4 regulation of circadian rhythm 33 35 6 6 6 4 4 4 64 31 2448 0.99796 0.013047 0.013047 11.43 360243;259241;316351;29657 top2a;nr1d2;npas2;arntl TOP2A_10059;NR1D2_9358;NPAS2_9350;ARNTL_8086 39.890575 26.0431 21.0878 31.191227130971196 49.836326584487836 35.26637729380732 13.1963425 11.371 3.35457 9.756603341936767 15.709661797752808 11.10323956636772 117.50815 82.0986 43.5624 101.60833093421361 150.2484140067634 111.74333670444366 0.5 22.0006 2.5 57.78055 86.3883;29.1728;21.0878;22.9134 26.6888;3.35457;11.3305;11.4115 262.273;114.038;43.5624;50.1592 1 3 1 259241 NR1D2_9358 29.1728 29.1728 3.35457 3.35457 114.038 114.038 29.1728 3.35457 114.038 3 360243;316351;29657 TOP2A_10059;NPAS2_9350;ARNTL_8086 43.463166666666666 22.9134 37.185460970698394 16.476933333333335 11.4115 8.843828688036265 118.66486666666667 50.1592 124.4120227798477 86.3883;21.0878;22.9134 26.6888;11.3305;11.4115 262.273;43.5624;50.1592 0 Exp 4,4(1) 2.5962328195640643 10.67015814781189 1.9603345394134521 3.442979335784912 0.7096143234019767 2.6334221363067627 9.32317241164823 70.45797758835177 3.6348712249019677 22.757813775098032 17.931985684470675 217.08431431552935 DOWN 0.25 0.75 0.0 GO:0032526 5 response to retinoic acid 42 45 8 7 4 7 4 4 64 41 2438 0.99376 0.030432 0.030432 8.89 684352;362282;81687;312495 twf2;pck1;mmp9;cyp26b1 TWF2_10109;PCK1_9439;MMP9_32531;CYP26B1_8418 353.53655000000003 333.8215 18.1872 331.700716556974 348.2289719055514 375.4562981795982 225.19347499999998 223.80964999999998 10.0176 207.54188346383447 215.07692083928876 229.8174016276081 849.003025 660.1125 36.7271 895.9079637371253 921.9826418615288 1056.943725612618 1.5 333.8215 138.399;529.244;728.316;18.1872 90.7363;356.883;443.137;10.0176 299.165;1021.06;2039.06;36.7271 2 2 2 362282;312495 PCK1_9439;CYP26B1_8418 273.7156 273.7156 361.3717288514972 183.4503 183.4503 245.27087649898422 528.89355 528.89355 696.0284685350197 529.244;18.1872 356.883;10.0176 1021.06;36.7271 2 684352;81687 TWF2_10109;MMP9_32531 433.3575 433.3575 417.13431103722456 266.93665 266.93665 249.1849246648862 1169.1125 1169.1125 1230.2915530525681 138.399;728.316 90.7363;443.137 299.165;2039.06 0 Exp 4,1(0.25);Linear,2(0.5);Poly 2,1(0.25) 1.876553170819329 7.547752618789673 1.611412525177002 2.090334892272949 0.2257064669452373 1.9230026006698608 28.469847774165487 678.6032522258345 21.80242920544228 428.58452079455776 -28.986779462382856 1726.9928294623828 CONFLICT 0.5 0.5 0.0 GO:0016043 4 cellular component organization 805 877 53 52 35 38 26 26 42 851 1628 0.78892 0.29178 0.51902 2.96 684352;360243;24832;295661;25671;288583;300795;338475;81687;316273;293502;25283;24367;309186;361921;312495;84032;24854;113902;114494;29397;686019;24232;81639;24646;170913 twf2;top2a;thy1;spc25;smad1;plod3;pclaf;nrep;mmp9;mcm3;kif22;gclc;fgg;fermt3;ect2;cyp26b1;col3a1;clu;ces1d;ccna2;ccl11;casq1;c3;alox15;abcb1b;abcb1a TWF2_10109;TOP2A_10059;THY1_33010;SPC25_9925;SMAD1_32578;PLOD3_9507;NS5ATP9_9367;NREP_9364;MMP9_32531;MCM3_9207;KIF22_8963;GCLC_8699;FGG_8639;FERMT3_32542;ECT2_8523;CYP26B1_8418;COL3A1_8354;CLU_32773;CES1D_32914;CCNA2_8221;CCL11_33230;CASQ1_32992;C3_8175;ALOX15_8036;ABCB1B_7939;ABCB1A_7938 259.25514230769255 135.0495 5.72311E-12 324.42214209199227 216.971839324727 304.48518619274756 160.2728661538464 65.32605 5.72311E-12 225.39045063317582 129.45985220441878 205.1599985835357 660.8387115384618 292.46900000000005 5.72313E-12 772.2094285351103 592.9520199961173 781.2586864406605 138.399;86.3883;5.72311E-12;35.8903;21.9973;882.629;292.216;61.543;728.316;197.273;17.3097;131.7;42.4612;539.113;10.0162;18.1872;212.603;935.649;11.0684;14.384;986.476;147.66;234.759;766.819;20.7941;206.982 90.7363;26.6888;5.72311E-12;11.5744;5.02186;625.677;147.515;25.6719;443.137;116.413;3.12114;39.9158;20.6424;334.248;3.29405;10.0176;119.81;808.484;4.18343;4.89199;552.974;96.6023;129.148;421.048;8.25355;118.025 299.165;262.273;5.72313E-12;124.006;80.1461;1106.02;658.494;148.788;2039.06;496.915;90.6321;397.209;98.0534;1187.86;37.7305;36.7271;1510.69;1071.05;17.0564;58.2504;2230.86;285.773;694.216;2662.07;57.2115;1531.55 2 24 2 312495;29397 CYP26B1_8418;CCL11_33230 502.3316 502.3316 684.6835766269847 281.49580000000003 281.49580000000003 383.9281523286356 1133.79355 1133.79355 1551.486252414505 18.1872;986.476 10.0176;552.974 36.7271;2230.86 24 684352;360243;24832;295661;25671;288583;300795;338475;81687;316273;293502;25283;24367;309186;361921;84032;24854;113902;114494;686019;24232;81639;24646;170913 TWF2_10109;TOP2A_10059;THY1_33010;SPC25_9925;SMAD1_32578;PLOD3_9507;NS5ATP9_9367;NREP_9364;MMP9_32531;MCM3_9207;KIF22_8963;GCLC_8699;FGG_8639;FERMT3_32542;ECT2_8523;COL3A1_8354;CLU_32773;CES1D_32914;CCNA2_8221;CASQ1_32992;C3_8175;ALOX15_8036;ABCB1B_7939;ABCB1A_7938 238.99877083333362 135.0495 297.41140692360125 150.17095500000025 65.32605 217.7734551606114 621.4258083333335 292.46900000000005 722.7941507891777 138.399;86.3883;5.72311E-12;35.8903;21.9973;882.629;292.216;61.543;728.316;197.273;17.3097;131.7;42.4612;539.113;10.0162;212.603;935.649;11.0684;14.384;147.66;234.759;766.819;20.7941;206.982 90.7363;26.6888;5.72311E-12;11.5744;5.02186;625.677;147.515;25.6719;443.137;116.413;3.12114;39.9158;20.6424;334.248;3.29405;119.81;808.484;4.18343;4.89199;96.6023;129.148;421.048;8.25355;118.025 299.165;262.273;5.72313E-12;124.006;80.1461;1106.02;658.494;148.788;2039.06;496.915;90.6321;397.209;98.0534;1187.86;37.7305;1510.69;1071.05;17.0564;58.2504;285.773;694.216;2662.07;57.2115;1531.55 0 Exp 2,3(0.12);Exp 4,8(0.31);Exp 5,1(0.04);Hill,4(0.16);Linear,1(0.04);Poly 2,8(0.31);Power,1(0.04) 1.8846824919745857 51.605303168296814 1.5021449327468872 6.191005229949951 0.9042099905291604 1.7512202858924866 134.5512856534412 383.9589989619438 73.63556616639144 246.9101661413013 364.01096340098155 957.666459675942 DOWN 0.07692307692307693 0.9230769230769231 0.0 GO:0010941 5 regulation of cell death 479 511 39 38 24 26 19 19 49 492 1987 0.95958 0.071845 0.12298 3.72 688621;360243;24832;25671;25682;25154;24314;316351;81687;24426;25283;24367;361921;245920;24854;246142;25612;252898;170913 tslp;top2a;thy1;smad1;ppard;pgr;nqo1;npas2;mmp9;gstp1;gclc;fgg;ect2;cxcl10;clu;bmf;asns;acox2;abcb1a TSLP_32811;TOP2A_10059;THY1_33010;SMAD1_32578;PPARD_9536;PGR_32824;NQO1_33055;NPAS2_9350;MMP9_32531;GSTP1_8762;GCLC_8699;FGG_8639;ECT2_8523;CXCL10_8408;CLU_32773;BMF_8152;ASNS_8091;ACOX2_32902;ABCB1A_7938 245.88787368421086 119.401 5.72311E-12 297.167797133955 214.46503562455266 267.45086824986714 153.53266157894765 39.9158 5.72311E-12 216.8687173328697 132.67230444358074 196.8936710998065 679.4235315789477 262.273 5.72313E-12 790.6236398348658 590.1516588777496 710.921726561753 344.675;86.3883;5.72311E-12;21.9973;94.1074;283.618;25.6813;21.0878;728.316;14.7631;131.7;42.4612;10.0162;670.528;935.649;119.401;191.145;743.353;206.982 244.2;26.6888;5.72311E-12;5.02186;37.7692;138.711;7.73944;11.3305;443.137;9.42992;39.9158;20.6424;3.29405;374.802;808.484;81.8286;113.564;432.537;118.025 560.435;262.273;5.72313E-12;80.1461;148.485;1554.21;86.1211;43.5624;2039.06;25.7196;397.209;98.0534;37.7305;1955.3;1071.05;220.085;510.267;2287.79;1531.55 2 17 2 24314;24426 NQO1_33055;GSTP1_8762 20.2222 20.2222 7.720333258350962 8.584679999999999 8.584679999999999 1.1953498714602508 55.92035 55.92035 42.710310243839245 25.6813;14.7631 7.73944;9.42992 86.1211;25.7196 17 688621;360243;24832;25671;25682;25154;316351;81687;25283;24367;361921;245920;24854;246142;25612;252898;170913 TSLP_32811;TOP2A_10059;THY1_33010;SMAD1_32578;PPARD_9536;PGR_32824;NPAS2_9350;MMP9_32531;GCLC_8699;FGG_8639;ECT2_8523;CXCL10_8408;CLU_32773;BMF_8152;ASNS_8091;ACOX2_32902;ABCB1A_7938 272.4367764705886 131.7 303.69234489776073 170.585365294118 81.8286 223.55256044160814 752.7768470588239 397.209 805.4786876813442 344.675;86.3883;5.72311E-12;21.9973;94.1074;283.618;21.0878;728.316;131.7;42.4612;10.0162;670.528;935.649;119.401;191.145;743.353;206.982 244.2;26.6888;5.72311E-12;5.02186;37.7692;138.711;11.3305;443.137;39.9158;20.6424;3.29405;374.802;808.484;81.8286;113.564;432.537;118.025 560.435;262.273;5.72313E-12;80.1461;148.485;1554.21;43.5624;2039.06;397.209;98.0534;37.7305;1955.3;1071.05;220.085;510.267;2287.79;1531.55 0 Exp 2,3(0.16);Exp 4,6(0.32);Exp 5,1(0.06);Hill,3(0.16);Linear,1(0.06);Poly 2,5(0.27) 1.9523909317750705 38.183919191360474 1.5319663286209106 3.5281898975372314 0.5486463414763627 1.863204002380371 112.26493589032921 379.5108114780925 56.016593535591724 251.0487296223036 323.9157865846119 1034.9312765732834 DOWN 0.10526315789473684 0.8947368421052632 0.0 GO:0051222 6 positive regulation of protein transport 131 141 8 8 5 6 4 4 64 137 2342 0.67693 0.52574 0.78834 2.84 688621;25682;24367;361921 tslp;ppard;fgg;ect2 TSLP_32811;PPARD_9536;FGG_8639;ECT2_8523 122.81495000000001 68.2843 10.0162 151.9059888589321 122.987141116924 157.6798304327794 76.4764125 29.205799999999996 3.29405 112.69804085301257 78.48949883033472 116.24588048866251 211.175975 123.26920000000001 37.7305 237.2003897291679 213.5357190676704 245.4732301030035 344.675;94.1074;42.4612;10.0162 244.2;37.7692;20.6424;3.29405 560.435;148.485;98.0534;37.7305 0 4 0 4 688621;25682;24367;361921 TSLP_32811;PPARD_9536;FGG_8639;ECT2_8523 122.81495000000001 68.2843 151.9059888589321 76.4764125 29.205799999999996 112.69804085301257 211.175975 123.26920000000001 237.2003897291679 344.675;94.1074;42.4612;10.0162 244.2;37.7692;20.6424;3.29405 560.435;148.485;98.0534;37.7305 0 Exp 2,1(0.25);Exp 4,2(0.5);Exp 5,1(0.25) 1.9701557116544788 8.078235268592834 1.6358354091644287 2.8176381587982178 0.5483409749321834 1.812380850315094 -26.05291908175343 271.68281908175345 -33.967667535952316 186.9204925359523 -21.28040693458459 443.63235693458455 DOWN 0.0 1.0 0.0 GO:0072330 7 monocarboxylic acid biosynthetic process 51 55 5 5 5 4 4 4 64 51 2428 0.98552 0.057185 0.057185 7.27 24426;24296;25612;81639 gstp1;cyp1a1;asns;alox15 GSTP1_8762;CYP1A1_8415;ASNS_8091;ALOX15_8036 246.40335 102.95405000000001 12.8863 356.8722236648153 285.34039189513925 352.2931664882472 138.29332 61.496959999999994 9.13136 194.80788493638752 160.4592176690333 191.7224021188444 804.345 267.9933 19.3234 1259.648161419254 924.9272316329875 1254.6221332965504 1.5 102.95405000000001 14.7631;12.8863;191.145;766.819 9.42992;9.13136;113.564;421.048 25.7196;19.3234;510.267;2662.07 2 2 2 24426;24296 GSTP1_8762;CYP1A1_8415 13.8247 13.8247 1.3270980069309275 9.28064 9.28064 0.2111138005910525 22.5215 22.5215 4.522796393825391 14.7631;12.8863 9.42992;9.13136 25.7196;19.3234 2 25612;81639 ASNS_8091;ALOX15_8036 478.98199999999997 478.98199999999997 407.06298915278455 267.306 267.306 217.42402150636445 1586.1685 1586.1685 1521.5544930775568 191.145;766.819 113.564;421.048 510.267;2662.07 0 Exp 2,1(0.25);Exp 4,2(0.5);Poly 2,1(0.25) 3.4890039971583335 22.322925329208374 1.5021449327468872 15.48720932006836 6.664317125889871 2.6667855381965637 -103.33142919151902 596.138129191519 -52.61840723765977 329.20504723765976 -430.1101981908687 2038.8001981908687 CONFLICT 0.5 0.5 0.0 GO:0031323 5 regulation of cellular metabolic process 979 1054 60 57 38 34 26 26 42 1028 1451 0.34343 0.7436 0.62 2.47 688621;360243;24832;25671;295703;25682;363131;25154;362282;304545;259241;316351;81687;24426;25283;24367;361921;24854;306575;113902;114494;29397;24232;246142;29657;81639 tslp;top2a;thy1;smad1;serping1;ppard;pik3r4;pgr;pck1;oasl;nr1d2;npas2;mmp9;gstp1;gclc;fgg;ect2;clu;ckap2;ces1d;ccna2;ccl11;c3;bmf;arntl;alox15 TSLP_32811;TOP2A_10059;THY1_33010;SMAD1_32578;SERPING1_32597;PPARD_9536;PIK3R4_9484;PGR_32824;PCK1_9439;OASL_9389;NR1D2_9358;NPAS2_9350;MMP9_32531;GSTP1_8762;GCLC_8699;FGG_8639;ECT2_8523;CLU_32773;CKAP2_8324;CES1D_32914;CCNA2_8221;CCL11_33230;C3_8175;BMF_8152;ARNTL_8086;ALOX15_8036 250.9959923076925 81.50045 5.72311E-12 336.8896679156211 239.07887925496019 325.00114077895665 159.50086230769256 27.56825 5.72311E-12 240.6346091684655 146.3649613036008 223.49267138213008 581.2031423076926 184.28500000000003 5.72313E-12 772.5541594601444 576.2558597425938 799.2107254253192 344.675;86.3883;5.72311E-12;21.9973;32.3997;94.1074;955.628;283.618;529.244;76.6126;29.1728;21.0878;728.316;14.7631;131.7;42.4612;10.0162;935.649;32.2386;11.0684;14.384;986.476;234.759;119.401;22.9134;766.819 244.2;26.6888;5.72311E-12;5.02186;13.7308;37.7692;735.228;138.711;356.883;28.4477;3.35457;11.3305;443.137;9.42992;39.9158;20.6424;3.29405;808.484;15.2683;4.18343;4.89199;552.974;129.148;81.8286;11.4115;421.048 560.435;262.273;5.72313E-12;80.1461;99.4885;148.485;1288.97;1554.21;1021.06;260.389;114.038;43.5624;2039.06;25.7196;397.209;98.0534;37.7305;1071.05;76.7052;17.0564;58.2504;2230.86;694.216;220.085;50.1592;2662.07 4 22 4 362282;259241;24426;29397 PCK1_9439;NR1D2_9358;GSTP1_8762;CCL11_33230 389.913975 279.20840000000004 464.1018135036922 230.6603725 183.15645999999998 271.06522408744866 847.9194 567.549 1025.8487203096306 529.244;29.1728;14.7631;986.476 356.883;3.35457;9.42992;552.974 1021.06;114.038;25.7196;2230.86 22 688621;360243;24832;25671;295703;25682;363131;25154;304545;316351;81687;25283;24367;361921;24854;306575;113902;114494;24232;246142;29657;81639 TSLP_32811;TOP2A_10059;THY1_33010;SMAD1_32578;SERPING1_32597;PPARD_9536;PIK3R4_9484;PGR_32824;OASL_9389;NPAS2_9350;MMP9_32531;GCLC_8699;FGG_8639;ECT2_8523;CLU_32773;CKAP2_8324;CES1D_32914;CCNA2_8221;C3_8175;BMF_8152;ARNTL_8086;ALOX15_8036 225.7381772727275 81.50045 316.2252697883113 146.5627695454548 27.56825 239.37009939525674 532.7092772727275 184.28500000000003 737.6802373565371 344.675;86.3883;5.72311E-12;21.9973;32.3997;94.1074;955.628;283.618;76.6126;21.0878;728.316;131.7;42.4612;10.0162;935.649;32.2386;11.0684;14.384;234.759;119.401;22.9134;766.819 244.2;26.6888;5.72311E-12;5.02186;13.7308;37.7692;735.228;138.711;28.4477;11.3305;443.137;39.9158;20.6424;3.29405;808.484;15.2683;4.18343;4.89199;129.148;81.8286;11.4115;421.048 560.435;262.273;5.72313E-12;80.1461;99.4885;148.485;1288.97;1554.21;260.389;43.5624;2039.06;397.209;98.0534;37.7305;1071.05;76.7052;17.0564;58.2504;694.216;220.085;50.1592;2662.07 0 Exp 2,2(0.08);Exp 4,12(0.47);Exp 5,2(0.08);Hill,2(0.08);Linear,2(0.08);Poly 2,5(0.2);Power,1(0.04) 1.9205753165269412 51.624574422836304 1.5018656253814697 3.5281898975372314 0.5808497451062533 1.790760576725006 121.49977301408066 380.49221160130435 67.00389642770304 251.99782818768202 284.24288386871893 878.1634007466662 DOWN 0.15384615384615385 0.8461538461538461 0.0 GO:0009612 4 response to mechanical stimulus 121 126 11 10 6 8 5 5 63 121 2358 0.8831 0.24432 0.38479 3.97 81687;25283;245920;84032;25612 mmp9;gclc;cxcl10;col3a1;asns MMP9_32531;GCLC_8699;CXCL10_8408;COL3A1_8354;ASNS_8091 386.8584 212.603 131.7 287.5918214332598 338.17946437468856 288.3121203981943 218.24576000000002 119.81 39.9158 178.56047327778901 189.01075248936414 186.49610529225492 1282.5052 1510.69 397.209 783.7725292670699 1043.8856114752214 816.9779323258945 728.316;131.7;670.528;212.603;191.145 443.137;39.9158;374.802;119.81;113.564 2039.06;397.209;1955.3;1510.69;510.267 0 5 0 5 81687;25283;245920;84032;25612 MMP9_32531;GCLC_8699;CXCL10_8408;COL3A1_8354;ASNS_8091 386.8584 212.603 287.5918214332598 218.24576000000002 119.81 178.56047327778901 1282.5052 1510.69 783.7725292670699 728.316;131.7;670.528;212.603;191.145 443.137;39.9158;374.802;119.81;113.564 2039.06;397.209;1955.3;1510.69;510.267 0 Exp 2,1(0.2);Hill,1(0.2);Linear,1(0.2);Poly 2,2(0.4) 1.8533618947385697 9.29820716381073 1.6129854917526245 2.05134654045105 0.16867440113715582 1.8538048267364502 134.77305390088205 638.943746099118 61.73060431328102 374.76091568671893 595.4982874994603 1969.5121125005398 DOWN 0.0 1.0 0.0 GO:0032414 6 positive regulation of ion transmembrane transporter activity 24 25 4 4 2 3 2 2 66 23 2456 0.97249 0.14238 0.14238 8.0 686019;170913 casq1;abcb1a CASQ1_32992;ABCB1A_7938 177.321 177.321 147.66 41.94698847354837 172.08381738299903 41.28793623411523 107.31365 107.31365 96.6023 15.148136441325086 105.42236865329514 14.910135726418261 908.6614999999999 908.6614999999999 285.773 880.8973645462337 798.67934078319 867.0571008719762 0.5 177.321 147.66;206.982 96.6023;118.025 285.773;1531.55 0 2 0 2 686019;170913 CASQ1_32992;ABCB1A_7938 177.321 177.321 41.94698847354837 107.31365 107.31365 15.148136441325086 908.6614999999999 908.6614999999999 880.8973645462337 147.66;206.982 96.6023;118.025 285.773;1531.55 0 Poly 2,2(1) 2.095777541820545 4.214543104171753 1.8874764442443848 2.327066659927368 0.3108372224526946 2.1072715520858765 119.18544 235.45656 86.31940399999999 128.307896 -312.19996000000003 2129.5229600000002 DOWN 0.0 1.0 0.0 GO:0060414 6 aorta smooth muscle tissue morphogenesis 2 2 1 1 1 1 1 1 67 1 2478 0.9993 0.052694 0.052694 50.0 84032 col3a1 COL3A1_8354 212.603 212.603 212.603 212.603 119.81 119.81 119.81 119.81 1510.69 1510.69 1510.69 1510.69 0.0 212.603 0.0 212.603 212.603 119.81 1510.69 0 1 0 1 84032 COL3A1_8354 212.603 212.603 119.81 119.81 1510.69 1510.69 212.603 119.81 1510.69 0 Poly 2,1(1) 1.6129854917526245 1.6129854917526245 1.6129854917526245 1.6129854917526245 0.0 1.6129854917526245 212.603 212.603 119.81 119.81 1510.69 1510.69 DOWN 0.0 1.0 0.0 GO:0071372 7 cellular response to follicle-stimulating hormone stimulus 17 19 2 2 2 2 2 2 66 17 2462 0.98701 0.089736 0.089736 10.53 25154;25283 pgr;gclc PGR_32824;GCLC_8699 207.659 207.659 131.7 107.42224798429798 164.62912625941723 88.52343923356698 89.3134 89.3134 39.9158 69.85875586868121 61.33024473087047 57.568496713806745 975.7095 975.7095 397.209 818.1232529396167 647.9958192792956 674.1907326101987 0.0 131.7 0.5 207.659 283.618;131.7 138.711;39.9158 1554.21;397.209 0 2 0 2 25154;25283 PGR_32824;GCLC_8699 207.659 207.659 107.42224798429798 89.3134 89.3134 69.85875586868121 975.7095 975.7095 818.1232529396167 283.618;131.7 138.711;39.9158 1554.21;397.209 0 Hill,1(0.5);Poly 2,1(0.5) 1.7441842353565558 3.515275239944458 1.5405861139297485 1.9746891260147095 0.30695718357878166 1.757637619972229 58.77936 356.53864 -7.505896000000021 186.132696 -158.15147999999988 2109.57048 DOWN 0.0 1.0 0.0 GO:0051607 5 defense response to virus 45 46 6 6 3 4 2 2 66 44 2435 0.87729 0.34927 0.34927 4.35 304545;245920 oasl;cxcl10 OASL_9389;CXCL10_8408 373.57030000000003 373.57030000000003 76.6126 419.96160679112086 344.0063438173747 417.8752160253628 201.62485 201.62485 28.4477 244.90947422311987 184.38400500951172 243.69275141512298 1107.8445 1107.8445 260.389 1198.4830616076727 1023.4751192136968 1192.5289363918896 76.6126;670.528 28.4477;374.802 260.389;1955.3 0 2 0 2 304545;245920 OASL_9389;CXCL10_8408 373.57030000000003 373.57030000000003 419.96160679112086 201.62485 201.62485 244.90947422311987 1107.8445 1107.8445 1198.4830616076727 76.6126;670.528 28.4477;374.802 260.389;1955.3 0 Exp 2,1(0.5);Exp 4,1(0.5) 1.8731732064181674 3.7465487718582153 1.8538048267364502 1.8927439451217651 0.027534114663681962 1.8732743859291077 -208.46679199999994 955.6073919999999 -137.80236399999998 541.052064 -553.1682799999999 2768.85728 DOWN 0.0 1.0 0.0 GO:0002694 5 regulation of leukocyte activation 146 156 8 8 5 6 4 4 64 152 2327 0.59541 0.60785 1.0 2.56 688621;24832;312495;29221 tslp;thy1;cyp26b1;arg1 TSLP_32811;THY1_33010;CYP26B1_8418;ARG1_33267 280.9473000000014 181.43110000000001 5.72311E-12 357.0322056849012 295.19811569691393 348.86225221601444 166.95615000000143 127.10879999999999 5.72311E-12 199.42193014432831 177.19512651075863 195.0179871128408 809.2730250000013 298.58104999999995 5.72313E-12 1246.9930978195505 829.5922768381673 1227.8843338678203 344.675;5.72311E-12;18.1872;760.927 244.2;5.72311E-12;10.0176;413.607 560.435;5.72313E-12;36.7271;2639.93 1 3 1 312495 CYP26B1_8418 18.1872 18.1872 10.0176 10.0176 36.7271 36.7271 18.1872 10.0176 36.7271 3 688621;24832;29221 TSLP_32811;THY1_33010;ARG1_33267 368.5340000000019 344.675 381.0241642507702 219.2690000000019 244.2 207.92752026366966 1066.788333333335 560.435 1390.9000233152371 344.675;5.72311E-12;760.927 244.2;5.72311E-12;413.607 560.435;5.72313E-12;2639.93 0 Exp 2,2(0.5);Exp 4,1(0.25);Hill,1(0.25) 1.7755347485819106 7.153026342391968 1.513624906539917 2.090334892272949 0.2468302507910086 1.7745332717895508 -68.94426157120176 630.8388615712046 -28.477341541440325 362.3896415414432 -412.78021086315835 2031.326260863161 DOWN 0.25 0.75 0.0 GO:0006486 6 protein glycosylation 32 33 2 2 2 2 2 2 66 31 2448 0.94386 0.21961 0.21961 6.06 288583;81919 plod3;fut1 PLOD3_9507;FUT1_8668 561.745 561.745 240.861 453.7985047485281 356.2069444615227 348.48428711051463 352.3248 352.3248 78.9726 386.5783885445228 177.2326181985859 296.8641208258774 976.9449999999999 976.9449999999999 847.87 182.53961556330833 894.2676944359052 140.1771648283792 0.5 561.745 882.629;240.861 625.677;78.9726 1106.02;847.87 0 2 0 2 288583;81919 PLOD3_9507;FUT1_8668 561.745 561.745 453.7985047485281 352.3248 352.3248 386.5783885445228 976.9449999999999 976.9449999999999 182.53961556330833 882.629;240.861 625.677;78.9726 1106.02;847.87 0 Exp 2,1(0.5);Poly 2,1(0.5) 2.167232149518603 4.453077435493469 1.7160688638687134 2.737008571624756 0.7219133905369097 2.2265387177467346 -67.18763999999999 1190.6776399999999 -183.445512 888.095112 723.958 1229.9319999999998 DOWN 0.0 1.0 0.0 GO:0010830 8 regulation of myotube differentiation 21 22 2 2 2 2 2 2 66 20 2459 0.98051 0.11526 0.11526 9.09 312495;245920 cyp26b1;cxcl10 CYP26B1_8418;CXCL10_8408 344.3576 344.3576 18.1872 461.27460332465745 136.220321304791 355.1506808483208 192.40980000000002 192.40980000000002 10.0176 257.94152291106604 76.02089357798164 198.59776978972678 996.01355 996.01355 36.7271 1356.6359077907398 383.8694952599388 1044.5191711021864 0.5 344.3576 18.1872;670.528 10.0176;374.802 36.7271;1955.3 1 1 1 312495 CYP26B1_8418 18.1872 18.1872 10.0176 10.0176 36.7271 36.7271 18.1872 10.0176 36.7271 1 245920 CXCL10_8408 670.528 670.528 374.802 374.802 1955.3 1955.3 670.528 374.802 1955.3 0 Exp 2,1(0.5);Exp 4,1(0.5) 1.9685204882833227 3.9441397190093994 1.8538048267364502 2.090334892272949 0.16725201329535697 1.9720698595046997 -294.936384 983.6515840000001 -165.07891199999997 549.898512 -884.1878919999997 2876.2149919999993 CONFLICT 0.5 0.5 0.0 GO:0045893 8 positive regulation of transcription, DNA-templated 299 321 18 17 12 12 10 10 58 311 2168 0.76929 0.35098 0.57817 3.12 360243;25671;25682;25154;362282;259241;316351;306575;114494;29657 top2a;smad1;ppard;pgr;pck1;nr1d2;npas2;ckap2;ccna2;arntl TOP2A_10059;SMAD1_32578;PPARD_9536;PGR_32824;PCK1_9439;NR1D2_9358;NPAS2_9350;CKAP2_8324;CCNA2_8221;ARNTL_8086 113.51516000000001 30.7057 14.384 167.18302895492312 72.8783907061738 107.40507921449765 61.13307199999999 13.3399 3.35457 111.51712580675806 33.30589999435845 67.91332548083332 340.88892999999996 97.09205 43.5624 518.5485117264409 228.90791806764943 392.2142676795606 86.3883;21.9973;94.1074;283.618;529.244;29.1728;21.0878;32.2386;14.384;22.9134 26.6888;5.02186;37.7692;138.711;356.883;3.35457;11.3305;15.2683;4.89199;11.4115 262.273;80.1461;148.485;1554.21;1021.06;114.038;43.5624;76.7052;58.2504;50.1592 2 8 2 362282;259241 PCK1_9439;NR1D2_9358 279.20840000000004 279.20840000000004 353.6037365960942 180.118785 180.118785 249.98235019523364 567.549 567.549 641.3614068853847 529.244;29.1728 356.883;3.35457 1021.06;114.038 8 360243;25671;25682;25154;316351;306575;114494;29657 TOP2A_10059;SMAD1_32578;PPARD_9536;PGR_32824;NPAS2_9350;CKAP2_8324;CCNA2_8221;ARNTL_8086 72.09185 27.576 90.93188938188847 31.38664375 13.3399 44.78432279807361 284.2239125 78.42565 518.2734535455679 86.3883;21.9973;94.1074;283.618;21.0878;32.2386;14.384;22.9134 26.6888;5.02186;37.7692;138.711;11.3305;15.2683;4.89199;11.4115 262.273;80.1461;148.485;1554.21;43.5624;76.7052;58.2504;50.1592 0 Exp 4,7(0.7);Exp 5,1(0.1);Linear,1(0.1);Poly 2,1(0.1) 2.0386180763105806 21.139283418655396 1.5405861139297485 3.442979335784912 0.6468624583156773 1.9496168494224548 9.894045105806413 217.13627489419363 -7.985958670319945 130.25210267031994 19.48923262816743 662.2886273718325 DOWN 0.2 0.8 0.0 GO:0070365 6 hepatocyte differentiation 9 9 2 2 2 2 2 2 66 7 2472 0.99864 0.022402 0.022402 22.22 362282;24296 pck1;cyp1a1 PCK1_9439;CYP1A1_8415 271.06515 271.06515 12.8863 365.1200311878889 149.75491305676854 322.30465401572945 183.00718 183.00718 9.13136 245.897542812743 101.30832309170303 217.0626525247953 520.1917 520.1917 19.3234 708.3347428227561 284.84921493449775 625.2726903808991 0.0 12.8863 0.0 12.8863 529.244;12.8863 356.883;9.13136 1021.06;19.3234 2 0 2 362282;24296 PCK1_9439;CYP1A1_8415 271.06515 271.06515 365.1200311878889 183.00718 183.00718 245.897542812743 520.1917 520.1917 708.3347428227561 529.244;12.8863 356.883;9.13136 1021.06;19.3234 0 0 Exp 4,1(0.5);Linear,1(0.5) 4.995626394997544 17.09862184524536 1.611412525177002 15.48720932006836 9.811670008034241 8.54931092262268 -234.965396 777.0956960000001 -157.78942719999992 523.8037872 -461.5101679999999 1501.893568 UP 1.0 0.0 0.0 GO:0071103 7 DNA conformation change 30 32 2 2 2 2 2 2 66 30 2449 0.948 0.2097 0.2097 6.25 360243;316273 top2a;mcm3 TOP2A_10059;MCM3_9207 141.83065 141.83065 86.3883 78.40732329983598 109.35341980114238 63.54657649524336 71.5509 71.5509 26.6888 63.44459025653802 45.27140880050772 51.419769713716306 379.59400000000005 379.59400000000005 262.273 165.91694935117368 310.86925936111703 134.47027229182115 0.5 141.83065 86.3883;197.273 26.6888;116.413 262.273;496.915 0 2 0 2 360243;316273 TOP2A_10059;MCM3_9207 141.83065 141.83065 78.40732329983598 71.5509 71.5509 63.44459025653802 379.59400000000005 379.59400000000005 165.91694935117368 86.3883;197.273 26.6888;116.413 262.273;496.915 0 Exp 4,1(0.5);Poly 2,1(0.5) 1.756738652952699 3.534622311592102 1.57428777217865 1.9603345394134521 0.27297628696687337 1.767311155796051 33.163644000000005 250.49765599999998 -16.378815999999986 159.480616 149.64484000000007 609.5431600000001 DOWN 0.0 1.0 0.0 GO:1901264 6 carbohydrate derivative transport 18 18 2 2 2 2 2 2 66 16 2463 0.98885 0.081657 0.081657 11.11 89776;170913 slc22a7;abcb1a SLC22A7_9847;ABCB1A_7938 128.0668 128.0668 49.1516 111.60294611738529 120.31339948399693 111.06298727729634 65.81225 65.81225 13.5995 73.83997917879583 60.68235914510844 73.48272562146016 846.4285 846.4285 161.307 968.9081171733984 779.1154678892685 964.2203331918588 0.0 49.1516 0.5 128.0668 49.1516;206.982 13.5995;118.025 161.307;1531.55 0 2 0 2 89776;170913 SLC22A7_9847;ABCB1A_7938 128.0668 128.0668 111.60294611738529 65.81225 65.81225 73.83997917879583 846.4285 846.4285 968.9081171733984 49.1516;206.982 13.5995;118.025 161.307;1531.55 0 Hill,1(0.5);Poly 2,1(0.5) 1.8924595499513064 3.784932255744934 1.8874764442443848 1.8974558115005493 0.007056478258784945 1.892466127872467 -26.60699199999999 282.740592 -36.524739999999994 168.14924000000002 -496.40963999999985 2189.26664 DOWN 0.0 1.0 0.0 GO:0009410 4 response to xenobiotic stimulus 123 132 11 10 6 9 6 6 62 126 2353 0.94056 0.1375 0.16301 4.55 25154;362282;25283;114494;29221;170913 pgr;pck1;gclc;ccna2;arg1;abcb1a PGR_32824;PCK1_9439;GCLC_8699;CCNA2_8221;ARG1_33267;ABCB1A_7938 321.1425 245.3 14.384 276.0965725000946 266.22994895279146 278.6411165941922 178.67229833333332 128.368 4.89199 168.33379327366572 137.73494488349385 161.70308502881815 1200.3682333333334 1276.3049999999998 58.2504 926.1611933466477 1097.5461947942622 999.3545843669372 283.618;529.244;131.7;14.384;760.927;206.982 138.711;356.883;39.9158;4.89199;413.607;118.025 1554.21;1021.06;397.209;58.2504;2639.93;1531.55 1 5 1 362282 PCK1_9439 529.244 529.244 356.883 356.883 1021.06 1021.06 529.244 356.883 1021.06 5 25154;25283;114494;29221;170913 PGR_32824;GCLC_8699;CCNA2_8221;ARG1_33267;ABCB1A_7938 279.5222 206.982 286.8706614350795 143.030158 118.025 160.91182738014888 1236.22988 1531.55 1030.8117007069097 283.618;131.7;14.384;760.927;206.982 138.711;39.9158;4.89199;413.607;118.025 1554.21;397.209;58.2504;2639.93;1531.55 0 Exp 2,1(0.17);Exp 4,1(0.17);Hill,1(0.17);Linear,1(0.17);Poly 2,2(0.34) 1.6837231696139094 10.154584288597107 1.513624906539917 1.9746891260147095 0.19163137456826676 1.6191038489341736 100.21923069685249 542.0657693031475 43.97721100404152 313.36738566262517 459.2849345329623 1941.451532133704 DOWN 0.16666666666666666 0.8333333333333334 0.0 GO:0034698 5 response to gonadotropin 33 36 5 5 4 5 4 4 64 32 2447 0.99768 0.014388 0.014388 11.11 25154;25283;114494;25612 pgr;gclc;ccna2;asns PGR_32824;GCLC_8699;CCNA2_8221;ASNS_8091 155.21175 161.4225 14.384 112.78980605939823 135.7460016186744 94.46346714926744 74.2706975 76.73989999999999 4.89199 62.423767493517175 62.64250149727381 55.79643285949016 629.9841 453.738 58.2504 645.3911912318296 465.0550260265803 466.4243248387585 0.5 73.042 2.5 237.38150000000002 283.618;131.7;14.384;191.145 138.711;39.9158;4.89199;113.564 1554.21;397.209;58.2504;510.267 0 4 0 4 25154;25283;114494;25612 PGR_32824;GCLC_8699;CCNA2_8221;ASNS_8091 155.21175 161.4225 112.78980605939823 74.2706975 76.73989999999999 62.423767493517175 629.9841 453.738 645.3911912318296 283.618;131.7;14.384;191.145 138.711;39.9158;4.89199;113.564 1554.21;397.209;58.2504;510.267 0 Exp 4,1(0.25);Hill,1(0.25);Poly 2,2(0.5) 1.7289069687656304 6.947451591491699 1.5405861139297485 1.9746891260147095 0.19312823862461062 1.7160881757736206 44.677740061789734 265.74575993821026 13.095405356353155 135.44598964364684 -2.499267407192974 1262.467467407193 DOWN 0.0 1.0 0.0 GO:0050770 8 regulation of axonogenesis 44 46 4 4 2 2 2 2 66 44 2435 0.87729 0.34927 0.34927 4.35 684352;24832 twf2;thy1 TWF2_10109;THY1_33010 69.19950000000286 69.19950000000286 5.72311E-12 97.86287140943297 66.49456417359485 97.78807823476868 45.36815000000286 45.36815000000286 5.72311E-12 64.16025302977287 43.59475663281307 64.11121758924014 149.58250000000288 149.58250000000288 5.72313E-12 211.54160019366944 143.73547706987065 211.3799263369332 138.399;5.72311E-12 90.7363;5.72311E-12 299.165;5.72313E-12 0 2 0 2 684352;24832 TWF2_10109;THY1_33010 69.19950000000286 69.19950000000286 97.86287140943297 45.36815000000286 45.36815000000286 64.16025302977287 149.58250000000288 149.58250000000288 211.54160019366944 138.399;5.72311E-12 90.7363;5.72311E-12 299.165;5.72313E-12 0 Hill,1(0.5);Poly 2,1(0.5) 1.8286101825906937 3.657862663269043 1.7946586608886719 1.863204002380371 0.048468875787528135 1.8289313316345215 -66.43151999999155 204.83051999999725 -43.553423999991516 134.28972399999725 -143.59919999999147 442.76419999999723 DOWN 0.0 1.0 0.0 GO:0006915 5 apoptotic process 137 149 5 5 3 2 2 2 66 147 2332 0.22866 0.91619 0.43287 1.34 25682;246142 ppard;bmf PPARD_9536;BMF_8152 106.7542 106.7542 94.1074 17.88527608061999 110.45945873925501 17.100444901532434 59.798899999999996 59.798899999999996 37.7692 31.154700515010575 66.25316024355301 29.787588247405658 184.28500000000003 184.28500000000003 148.485 50.62884553295679 194.7736819484241 48.407180272864395 94.1074;119.401 37.7692;81.8286 148.485;220.085 0 2 0 2 25682;246142 PPARD_9536;BMF_8152 106.7542 106.7542 17.88527608061999 59.798899999999996 59.798899999999996 31.154700515010575 184.28500000000003 184.28500000000003 50.62884553295679 94.1074;119.401 37.7692;81.8286 148.485;220.085 0 Exp 5,1(0.5);Poly 2,1(0.5) 1.7631799090450118 3.5422849655151367 1.6033858060836792 1.9388991594314575 0.23724376733085228 1.7711424827575684 81.96647200000001 131.54192799999998 16.620688 102.97711199999999 114.11700000000003 254.45300000000003 DOWN 0.0 1.0 0.0 GO:0006457 3 protein folding 33 38 4 3 2 3 2 2 66 36 2443 0.92093 0.26959 0.26959 5.26 291463;24854 ppic;clu PPIC_9541;CLU_32773 782.1635 782.1635 628.678 217.06127572761542 799.6852766109445 215.6422317388041 598.8615 598.8615 389.239 296.45098247855435 622.7918296899558 294.51292612440676 1290.455 1290.455 1071.05 310.2855266524688 1265.4079082726105 308.2570265898217 0.5 782.1635 628.678;935.649 389.239;808.484 1509.86;1071.05 0 2 0 2 291463;24854 PPIC_9541;CLU_32773 782.1635 782.1635 217.06127572761542 598.8615 598.8615 296.45098247855435 1290.455 1290.455 310.2855266524688 628.678;935.649 389.239;808.484 1509.86;1071.05 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.822949944679732 3.6921244859695435 1.5548590421676636 2.13726544380188 0.4118235160020103 1.8460622429847717 481.33192 1082.99508 188.00140000000005 1009.7215999999999 860.4212 1720.4887999999999 DOWN 0.0 1.0 0.0 GO:0009416 5 response to light stimulus 83 88 7 7 7 5 5 5 63 83 2396 0.97185 0.083368 0.083368 5.68 300795;81687;24854;246142;25612 pclaf;mmp9;clu;bmf;asns NS5ATP9_9367;MMP9_32531;CLU_32773;BMF_8152;ASNS_8091 453.3454 292.216 119.401 358.62800679576054 424.04408952366657 356.92851794551785 318.90572000000003 147.515 81.8286 309.38077868557383 292.4872781802485 288.2067643146243 899.7912 658.494 220.085 706.9683399316407 911.0815600765737 790.5965961809361 3.5 831.9825000000001 292.216;728.316;935.649;119.401;191.145 147.515;443.137;808.484;81.8286;113.564 658.494;2039.06;1071.05;220.085;510.267 0 5 0 5 300795;81687;24854;246142;25612 NS5ATP9_9367;MMP9_32531;CLU_32773;BMF_8152;ASNS_8091 453.3454 292.216 358.62800679576054 318.90572000000003 147.515 309.38077868557383 899.7912 658.494 706.9683399316407 292.216;728.316;935.649;119.401;191.145 147.515;443.137;808.484;81.8286;113.564 658.494;2039.06;1071.05;220.085;510.267 0 Exp 2,1(0.2);Linear,1(0.2);Poly 2,3(0.6) 1.72746880032146 8.681122422218323 1.5548590421676636 2.05134654045105 0.19970888214101692 1.6661498546600342 138.99409208241389 767.6967079175861 47.721510787477655 590.0899292125224 280.1061277172877 1519.4762722827127 DOWN 0.0 1.0 0.0 GO:0071214 4 cellular response to abiotic stimulus 122 125 9 8 8 5 5 5 63 120 2359 0.88637 0.23926 0.38284 4.0 362282;25283;361921;246142;170913 pck1;gclc;ect2;bmf;abcb1a PCK1_9439;GCLC_8699;ECT2_8523;BMF_8152;ABCB1A_7938 199.46864 131.7 10.0162 197.2966555761856 134.98502792669493 116.35451683039085 119.98928999999998 81.8286 3.29405 139.29130390433747 71.86352757619254 79.67760813125759 641.5269000000001 397.209 37.7305 620.092956039294 547.5057901325233 618.6714067822531 529.244;131.7;10.0162;119.401;206.982 356.883;39.9158;3.29405;81.8286;118.025 1021.06;397.209;37.7305;220.085;1531.55 1 4 1 362282 PCK1_9439 529.244 529.244 356.883 356.883 1021.06 1021.06 529.244 356.883 1021.06 4 25283;361921;246142;170913 GCLC_8699;ECT2_8523;BMF_8152;ABCB1A_7938 117.0248 125.5505 81.16679560690649 60.7658625 60.87219999999999 49.86642850832236 546.6436249999999 308.647 672.806158073207 131.7;10.0162;119.401;206.982 39.9158;3.29405;81.8286;118.025 397.209;37.7305;220.085;1531.55 0 Exp 4,1(0.2);Hill,1(0.2);Linear,1(0.2);Poly 2,2(0.4) 1.7356930715311043 8.712799310684204 1.6033858060836792 1.9746891260147095 0.17524551467186 1.6358354091644287 26.530496428128174 372.4067835718718 -2.1049210882347182 242.0835010882347 97.99145918752095 1185.0623408124789 DOWN 0.2 0.8 0.0 GO:0104004 4 cellular response to environmental stimulus 122 125 9 8 8 5 5 5 63 120 2359 0.88637 0.23926 0.38284 4.0 362282;25283;361921;246142;170913 pck1;gclc;ect2;bmf;abcb1a PCK1_9439;GCLC_8699;ECT2_8523;BMF_8152;ABCB1A_7938 199.46864 131.7 10.0162 197.2966555761856 134.98502792669493 116.35451683039085 119.98928999999998 81.8286 3.29405 139.29130390433747 71.86352757619254 79.67760813125759 641.5269000000001 397.209 37.7305 620.092956039294 547.5057901325233 618.6714067822531 529.244;131.7;10.0162;119.401;206.982 356.883;39.9158;3.29405;81.8286;118.025 1021.06;397.209;37.7305;220.085;1531.55 1 4 1 362282 PCK1_9439 529.244 529.244 356.883 356.883 1021.06 1021.06 529.244 356.883 1021.06 4 25283;361921;246142;170913 GCLC_8699;ECT2_8523;BMF_8152;ABCB1A_7938 117.0248 125.5505 81.16679560690649 60.7658625 60.87219999999999 49.86642850832236 546.6436249999999 308.647 672.806158073207 131.7;10.0162;119.401;206.982 39.9158;3.29405;81.8286;118.025 397.209;37.7305;220.085;1531.55 0 Exp 4,1(0.2);Hill,1(0.2);Linear,1(0.2);Poly 2,2(0.4) 1.7356930715311043 8.712799310684204 1.6033858060836792 1.9746891260147095 0.17524551467186 1.6358354091644287 26.530496428128174 372.4067835718718 -2.1049210882347182 242.0835010882347 97.99145918752095 1185.0623408124789 DOWN 0.2 0.8 0.0 GO:0060700 7 regulation of ribonuclease activity 4 5 1 1 1 1 1 1 67 4 2475 0.99333 0.12664 0.12664 20.0 304545 oasl OASL_9389 76.6126 76.6126 76.6126 76.6126 28.4477 28.4477 28.4477 28.4477 260.389 260.389 260.389 260.389 0.0 76.6126 0.0 76.6126 76.6126 28.4477 260.389 0 1 0 1 304545 OASL_9389 76.6126 76.6126 28.4477 28.4477 260.389 260.389 76.6126 28.4477 260.389 0 Exp 4,1(1) 1.8927439451217651 1.8927439451217651 1.8927439451217651 1.8927439451217651 0.0 1.8927439451217651 76.6126 76.6126 28.4477 28.4477 260.389 260.389 DOWN 0.0 1.0 0.0 GO:0005975 4 carbohydrate metabolic process 100 118 4 4 4 4 4 4 64 114 2365 0.7952 0.38749 0.55462 3.39 286989;362282;25283;81919 ugt2b7;pck1;gclc;fut1 UGT2B7_33032;PCK1_9439;GCLC_8699;FUT1_8668 234.1294 186.2805 34.7126 214.0068407616292 163.885193766212 133.48904922872043 122.63607499999999 59.444199999999995 14.7729 158.3826898561282 62.72697681365576 83.69390998336597 592.79075 622.5395 105.024 418.1899877706104 505.81951079407577 360.76382839565684 34.7126;529.244;131.7;240.861 14.7729;356.883;39.9158;78.9726 105.024;1021.06;397.209;847.87 2 2 2 286989;362282 UGT2B7_33032;PCK1_9439 281.9783 281.9783 349.6865064496771 185.82795 185.82795 241.9083716224079 563.0419999999999 563.0419999999999 647.7352674110002 34.7126;529.244 14.7729;356.883 105.024;1021.06 2 25283;81919 GCLC_8699;FUT1_8668 186.2805 186.2805 77.18848334110469 59.444199999999995 59.444199999999995 27.617328131446758 622.5395 622.5395 318.6654491163108 131.7;240.861 39.9158;78.9726 397.209;847.87 0 Exp 2,1(0.25);Exp 4,1(0.25);Hill,1(0.25);Linear,1(0.25) 2.68085887614186 12.253922581672668 1.611412525177002 5.930812358856201 1.9682601427318207 2.3558488488197327 24.402696053603307 443.8561039463966 -32.578961059005664 277.85111105900563 182.96456198480178 1002.6169380151982 CONFLICT 0.5 0.5 0.0 GO:2000431 6 regulation of cytokinesis, actomyosin contractile ring assembly 1 1 1 1 1 1 1 1 67 0 2479 1.0 0.026698 0.026698 100.0 361921 ect2 ECT2_8523 10.0162 10.0162 10.0162 10.0162 3.29405 3.29405 3.29405 3.29405 37.7305 37.7305 37.7305 37.7305 0.0 10.0162 0.0 10.0162 10.0162 3.29405 37.7305 0 1 0 1 361921 ECT2_8523 10.0162 10.0162 3.29405 3.29405 37.7305 37.7305 10.0162 3.29405 37.7305 0 Exp 4,1(1) 1.6358354091644287 1.6358354091644287 1.6358354091644287 1.6358354091644287 0.0 1.6358354091644287 10.0162 10.0162 3.29405 3.29405 37.7305 37.7305 DOWN 0.0 1.0 0.0 GO:0048732 5 gland development 137 157 12 12 8 8 6 6 62 151 2328 0.87794 0.23919 0.30884 3.82 116669;25154;25315;24296;25612;29221 vwf;pgr;ephx1;cyp1a1;asns;arg1 VWF_32396;PGR_32824;EPHX1_8567;CYP1A1_8415;ASNS_8091;ARG1_33267 217.91513333333333 115.19155 12.8863 287.4565338273435 204.99239740897707 291.59910166585325 116.34808333333335 66.26135 4.11644 156.49075002272278 110.30527625441468 159.7049845036769 816.58415 302.1725 19.3234 1063.9748002735284 719.4518844763372 1046.4981250331493 19.6764;283.618;39.2381;12.8863;191.145;760.927 4.11644;138.711;18.9587;9.13136;113.564;413.607 94.078;1554.21;81.6965;19.3234;510.267;2639.93 2 4 2 25315;24296 EPHX1_8567;CYP1A1_8415 26.0622 26.0622 18.633536476471672 14.04503 14.04503 6.948978755025805 50.50995 50.50995 44.10444197362663 39.2381;12.8863 18.9587;9.13136 81.6965;19.3234 4 116669;25154;25612;29221 VWF_32396;PGR_32824;ASNS_8091;ARG1_33267 313.84159999999997 237.38150000000002 317.4830396691662 167.49961000000002 126.1375 174.16538284407073 1199.6212500000001 1032.2385 1139.832975566559 19.6764;283.618;191.145;760.927 4.11644;138.711;113.564;413.607 94.078;1554.21;510.267;2639.93 0 Exp 2,1(0.17);Exp 4,2(0.34);Hill,1(0.17);Poly 2,2(0.34) 2.556703172115158 24.48652219772339 1.513624906539917 15.48720932006836 5.593128881379352 1.9269066452980042 -12.097998161320618 447.92826482798733 -8.870595760227928 241.5667624268946 -34.77300088426432 1667.9413008842644 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:1905954 5 positive regulation of lipid localization 34 36 4 3 2 2 2 2 66 34 2445 0.93054 0.24955 0.24955 5.56 113902;24232 ces1d;c3 CES1D_32914;C3_8175 122.91369999999999 122.91369999999999 11.0684 158.17314014768752 143.47229488054606 155.47807117807693 66.66571499999999 66.66571499999999 4.18343 88.363294855061 78.1507571477328 86.85769678832183 355.63620000000003 355.63620000000003 17.0564 478.82414510557004 417.87149234519745 470.66559116797106 0.5 122.91369999999999 11.0684;234.759 4.18343;129.148 17.0564;694.216 0 2 0 2 113902;24232 CES1D_32914;C3_8175 122.91369999999999 122.91369999999999 158.17314014768752 66.66571499999999 66.66571499999999 88.363294855061 355.63620000000003 355.63620000000003 478.82414510557004 11.0684;234.759 4.18343;129.148 17.0564;694.216 0 Exp 5,1(0.5);Poly 2,1(0.5) 1.586358170080694 3.1737300157546997 1.5467612743377686 1.6269687414169312 0.05671524387347264 1.5868650078773499 -96.30308799999999 342.13048799999996 -55.799563599999985 189.13099359999995 -307.9802079999999 1019.2526079999998 DOWN 0.0 1.0 0.0 GO:0034220 5 ion transmembrane transport 134 136 8 8 5 6 4 4 64 132 2347 0.70368 0.4967 0.7824 2.94 313089;294881;170551;170945 slc7a13;slc7a12;slc5a6;chrna2 SLC7A13_32952;SLC7A12_32838;SLC5A6_9881;CHRNA2_32401 179.850825 141.77800000000002 37.9163 154.42940018442894 166.5784803196147 128.31760324394264 119.92375 92.09285 15.3983 113.03344626691988 109.72277137040278 93.69455486187739 358.98175000000003 317.824 132.15 237.382782757266 349.280648905429 204.53748674221515 397.931;37.9163;120.077;163.479 280.111;15.3983;82.2177;101.968 668.129;132.15;221.286;414.362 0 4 0 4 313089;294881;170551;170945 SLC7A13_32952;SLC7A12_32838;SLC5A6_9881;CHRNA2_32401 179.850825 141.77800000000002 154.42940018442894 119.92375 92.09285 113.03344626691988 358.98175000000003 317.824 237.382782757266 397.931;37.9163;120.077;163.479 280.111;15.3983;82.2177;101.968 668.129;132.15;221.286;414.362 0 Exp 2,1(0.25);Exp 4,1(0.25);Poly 2,2(0.5) 1.8765055052902264 7.603714346885681 1.517665982246399 2.3742122650146484 0.35660566527867227 1.855918049812317 28.51001281925963 331.1916371807404 9.15097265841851 230.6965273415815 126.34662289787931 591.6168771021206 DOWN 0.0 1.0 0.0 GO:0045859 7 regulation of protein kinase activity 207 223 15 14 8 7 5 5 63 218 2261 0.44405 0.7244 0.82953 2.24 24832;24426;361921;24854;114494 thy1;gstp1;ect2;clu;ccna2 THY1_33010;GSTP1_8762;ECT2_8523;CLU_32773;CCNA2_8221 194.96246000000116 14.384 5.72311E-12 414.0991487538913 170.0813528911724 391.008369315972 165.21999200000116 4.89199 5.72311E-12 359.61154569770383 143.0678454843717 339.83745753979895 238.55010000000112 37.7305 5.72313E-12 465.85822655731783 213.9648908527415 438.1857839568882 5.72311E-12;14.7631;10.0162;935.649;14.384 5.72311E-12;9.42992;3.29405;808.484;4.89199 5.72313E-12;25.7196;37.7305;1071.05;58.2504 1 4 1 24426 GSTP1_8762 14.7631 14.7631 9.42992 9.42992 25.7196 25.7196 14.7631 9.42992 25.7196 4 24832;361921;24854;114494 THY1_33010;ECT2_8523;CLU_32773;CCNA2_8221 240.01230000000143 12.200099999999999 463.79688741023887 204.16751000000144 4.09302 402.88280844813085 291.7577250000014 47.990449999999996 520.087980326952 5.72311E-12;10.0162;935.649;14.384 5.72311E-12;3.29405;808.484;4.89199 5.72313E-12;37.7305;1071.05;58.2504 0 Exp 4,3(0.6);Hill,1(0.2);Poly 2,1(0.2) 1.936043775204636 10.20888352394104 1.5548590421676636 3.5281898975372314 0.8389575685440847 1.6358354091644287 -168.01144764709016 557.9363676470925 -149.99342577614323 480.4334097761455 -169.79263968418576 646.892839684188 DOWN 0.2 0.8 0.0 GO:1902533 7 positive regulation of intracellular signal transduction 254 269 16 16 10 11 8 8 60 261 2218 0.71327 0.42991 0.68974 2.97 25682;24367;29243;84032;24854;29397;24232;81639 ppard;fgg;f10;col3a1;clu;ccl11;c3;alox15 PPARD_9536;FGG_8639;F10_8585;COL3A1_8354;CLU_32773;CCL11_33230;C3_8175;ALOX15_8036 422.133075 223.68099999999998 42.4612 402.28653620745695 420.8176577667379 417.8146780944183 266.0373125 124.479 20.6424 293.954274989697 261.20944241811566 295.6061931483631 1072.30855 882.633 98.0534 988.0790784535808 1038.3682800820286 1059.9661987361617 94.1074;42.4612;104.19;212.603;935.649;986.476;234.759;766.819 37.7692;20.6424;38.4229;119.81;808.484;552.974;129.148;421.048 148.485;98.0534;163.044;1510.69;1071.05;2230.86;694.216;2662.07 1 7 1 29397 CCL11_33230 986.476 986.476 552.974 552.974 2230.86 2230.86 986.476 552.974 2230.86 7 25682;24367;29243;84032;24854;24232;81639 PPARD_9536;FGG_8639;F10_8585;COL3A1_8354;CLU_32773;C3_8175;ALOX15_8036 341.51265714285717 212.603 357.9712979813644 225.04635714285718 119.81 291.7674127656928 906.8012 694.216 939.868041652522 94.1074;42.4612;104.19;212.603;935.649;234.759;766.819 37.7692;20.6424;38.4229;119.81;808.484;129.148;421.048 148.485;98.0534;163.044;1510.69;1071.05;694.216;2662.07 0 Exp 2,1(0.13);Exp 4,1(0.13);Exp 5,2(0.25);Poly 2,3(0.38);Power,1(0.13) 1.769316752872238 14.477270126342773 1.5021449327468872 2.8176381587982178 0.4491243980592701 1.583922266960144 143.3627280223065 700.9034219776936 62.33739252008991 469.73723247991006 387.6046816113801 1757.0124183886198 DOWN 0.125 0.875 0.0 GO:0010821 7 regulation of mitochondrion organization 47 48 5 5 3 4 3 3 65 45 2434 0.96255 0.13477 0.13477 6.25 81687;25283;246142 mmp9;gclc;bmf MMP9_32531;GCLC_8699;BMF_8152 326.4723333333333 131.7 119.401 348.06115221370703 305.5411167611623 337.39602703307565 188.2938 81.8286 39.9158 221.69339895594547 173.46821975549253 216.2356802480543 885.4513333333333 397.209 220.085 1002.9720557923503 829.787685196669 969.1305622579027 1.5 430.00800000000004 728.316;131.7;119.401 443.137;39.9158;81.8286 2039.06;397.209;220.085 0 3 0 3 81687;25283;246142 MMP9_32531;GCLC_8699;BMF_8152 326.4723333333333 131.7 348.06115221370703 188.2938 81.8286 221.69339895594547 885.4513333333333 397.209 1002.9720557923503 728.316;131.7;119.401 443.137;39.9158;81.8286 2039.06;397.209;220.085 0 Hill,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 1.8657721273336436 5.6294214725494385 1.6033858060836792 2.05134654045105 0.23958691328855444 1.9746891260147095 -67.39593851973535 720.3406051864022 -62.57589738696532 439.16349738696533 -249.5183920133827 2020.4210586800496 DOWN 0.0 1.0 0.0 GO:0010887 6 negative regulation of cholesterol storage 6 6 2 2 2 2 2 2 66 4 2475 0.99966 0.0098306 0.0098306 33.33 25682;113902 ppard;ces1d PPARD_9536;CES1D_32914 52.5879 52.5879 11.0684 58.717440002949715 69.38180661686232 53.69978735142456 20.976315 20.976315 4.18343 23.748725718371716 27.76874127001067 21.71929704155703 82.7707 82.7707 17.0564 92.9340543018543 109.35097716115261 84.99244778833365 0.0 11.0684 0.0 11.0684 94.1074;11.0684 37.7692;4.18343 148.485;17.0564 0 2 0 2 25682;113902 PPARD_9536;CES1D_32914 52.5879 52.5879 58.717440002949715 20.976315 20.976315 23.748725718371716 82.7707 82.7707 92.9340543018543 94.1074;11.0684 37.7692;4.18343 148.485;17.0564 0 Exp 5,2(1) 1.776099187870583 3.5658679008483887 1.6269687414169312 1.9388991594314575 0.220568113836426 1.7829339504241943 -28.79032 133.96612 -11.937739599999993 53.89036959999999 -46.02932799999999 211.570728 DOWN 0.0 1.0 0.0 GO:0035556 5 intracellular signal transduction 318 334 17 17 12 10 7 7 61 327 2152 0.31443 0.8082 0.58717 2.1 25671;361921;245920;24854;114494;29397;686019 smad1;ect2;cxcl10;clu;ccna2;ccl11;casq1 SMAD1_32578;ECT2_8523;CXCL10_8408;CLU_32773;CCNA2_8221;CCL11_33230;CASQ1_32992 398.10150000000004 147.66 10.0162 449.32963011041613 333.729725950742 435.8639323461432 263.7243142857143 96.6023 3.29405 322.08735106396756 223.54704274346037 309.3008704458741 817.0157142857144 285.773 37.7305 945.81411977337 644.0586122288513 870.0285552417623 21.9973;10.0162;670.528;935.649;14.384;986.476;147.66 5.02186;3.29405;374.802;808.484;4.89199;552.974;96.6023 80.1461;37.7305;1955.3;1071.05;58.2504;2230.86;285.773 1 6 1 29397 CCL11_33230 986.476 986.476 552.974 552.974 2230.86 2230.86 986.476 552.974 2230.86 6 25671;361921;245920;24854;114494;686019 SMAD1_32578;ECT2_8523;CXCL10_8408;CLU_32773;CCNA2_8221;CASQ1_32992 300.03908333333334 84.82865 401.87080544515504 215.51603333333333 50.81208 323.98517234352124 581.375 182.95955 779.1368497709012 21.9973;10.0162;670.528;935.649;14.384;147.66 5.02186;3.29405;374.802;808.484;4.89199;96.6023 80.1461;37.7305;1955.3;1071.05;58.2504;285.773 0 Exp 2,1(0.15);Exp 4,3(0.43);Poly 2,2(0.29);Power,1(0.15) 1.7943428510120147 12.673055410385132 1.5548590421676636 2.327066659927368 0.2712051149113624 1.6932154893875122 65.23345176985572 730.9695482301443 25.118665506366597 502.329963065062 116.34680900985177 1517.684619561577 DOWN 0.14285714285714285 0.8571428571428571 0.0 GO:0050776 5 regulation of immune response 176 199 12 12 8 9 6 6 62 193 2286 0.72129 0.44151 0.65004 3.02 24832;295703;84032;24232;29221;81639 thy1;serping1;col3a1;c3;arg1;alox15 THY1_33010;SERPING1_32597;COL3A1_8354;C3_8175;ARG1_33267;ALOX15_8036 334.5846166666676 223.68099999999998 5.72311E-12 345.45669716484133 415.85140655047894 369.4071308544486 182.8906333333343 124.479 5.72311E-12 189.14568092305532 227.11375474132106 202.19466632969832 1267.7324166666676 1102.453 5.72313E-12 1198.9155350218123 1518.4560173825544 1263.1835541089752 5.72311E-12;32.3997;212.603;234.759;760.927;766.819 5.72311E-12;13.7308;119.81;129.148;413.607;421.048 5.72313E-12;99.4885;1510.69;694.216;2639.93;2662.07 0 6 0 6 24832;295703;84032;24232;29221;81639 THY1_33010;SERPING1_32597;COL3A1_8354;C3_8175;ARG1_33267;ALOX15_8036 334.5846166666676 223.68099999999998 345.45669716484133 182.8906333333343 124.479 189.14568092305532 1267.7324166666676 1102.453 1198.9155350218123 5.72311E-12;32.3997;212.603;234.759;760.927;766.819 5.72311E-12;13.7308;119.81;129.148;413.607;421.048 5.72313E-12;99.4885;1510.69;694.216;2639.93;2662.07 0 Exp 2,2(0.34);Exp 4,1(0.17);Hill,1(0.17);Poly 2,2(0.34) 1.621279648702845 9.75703775882721 1.5021449327468872 1.863204002380371 0.14085766434259017 1.5798733830451965 58.16168881486334 611.0075445184718 31.542567597831408 334.23869906883715 308.40019020355123 2227.064643129784 DOWN 0.0 1.0 0.0 GO:0071347 7 cellular response to interleukin-1 47 50 8 8 5 6 4 4 64 46 2433 0.99023 0.042611 0.042611 8.0 362282;81687;24367;29397 pck1;mmp9;fgg;ccl11 PCK1_9439;MMP9_32531;FGG_8639;CCL11_33230 571.6243000000001 628.78 42.4612 399.359444640823 540.1385364437426 443.77450944364216 343.40909999999997 400.01 20.6424 229.65408041989306 317.3471935516732 258.0292955506571 1347.25835 1530.06 98.0534 987.6334963727975 1345.650147048337 1100.1686283811005 1.5 628.78 529.244;728.316;42.4612;986.476 356.883;443.137;20.6424;552.974 1021.06;2039.06;98.0534;2230.86 2 2 2 362282;29397 PCK1_9439;CCL11_33230 757.86 757.86 323.3118477754875 454.9285 454.9285 138.65727582965147 1625.96 1625.96 855.4577838794855 529.244;986.476 356.883;552.974 1021.06;2230.86 2 81687;24367 MMP9_32531;FGG_8639 385.3886 385.3886 484.97257998934344 231.8897 231.8897 298.7487966746979 1068.5566999999999 1068.5566999999999 1372.4989291878446 728.316;42.4612 443.137;20.6424 2039.06;98.0534 0 Exp 4,1(0.25);Linear,2(0.5);Power,1(0.25) 2.0726697318023835 8.461876034736633 1.611412525177002 2.8176381587982178 0.5063528144584747 2.016412675380707 180.2520442519932 962.9965557480067 118.34810118850484 568.4700988114951 379.3775235546584 2315.139176445342 CONFLICT 0.5 0.5 0.0 GO:0000904 5 cell morphogenesis involved in differentiation 40 43 3 3 2 2 2 2 66 41 2438 0.89457 0.3196 0.3196 4.65 288583;309186 plod3;fermt3 PLOD3_9507;FERMT3_32542 710.8710000000001 710.8710000000001 539.113 242.90249304607752 659.4980277722278 231.782778861953 479.9625 479.9625 334.248 206.07142213441455 436.3791620379621 196.63777949487132 1146.94 1146.94 1106.02 57.869618972307315 1159.1792087912088 55.22043404692136 882.629;539.113 625.677;334.248 1106.02;1187.86 0 2 0 2 288583;309186 PLOD3_9507;FERMT3_32542 710.8710000000001 710.8710000000001 242.90249304607752 479.9625 479.9625 206.07142213441455 1146.94 1146.94 57.869618972307315 882.629;539.113 625.677;334.248 1106.02;1187.86 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.6930672975140777 3.3864428997039795 1.6703740358352661 1.7160688638687134 0.032311122767603714 1.6932214498519897 374.2253200000002 1047.51668 194.36208 765.56292 1066.7368000000001 1227.1432 DOWN 0.0 1.0 0.0 GO:0031334 7 positive regulation of protein-containing complex assembly 61 68 4 4 4 4 4 4 64 64 2415 0.96674 0.10592 0.10592 5.88 24854;29397;246142;81639 clu;ccl11;bmf;alox15 CLU_32773;CCL11_33230;BMF_8152;ALOX15_8036 702.08625 851.2339999999999 119.401 399.64213891211466 625.9563101392598 433.46051515160576 466.08365000000003 487.011 81.8286 302.47208456576067 406.72021280045783 308.42496200684826 1546.0162500000001 1650.955 220.085 1110.296289760643 1425.8871761732164 1176.8968887156436 2.5 961.0625 935.649;986.476;119.401;766.819 808.484;552.974;81.8286;421.048 1071.05;2230.86;220.085;2662.07 1 3 1 29397 CCL11_33230 986.476 986.476 552.974 552.974 2230.86 2230.86 986.476 552.974 2230.86 3 24854;246142;81639 CLU_32773;BMF_8152;ALOX15_8036 607.2896666666667 766.819 430.87400190929753 437.1202 421.048 363.5942165339268 1317.735 1071.05 1239.5413675932725 935.649;119.401;766.819 808.484;81.8286;421.048 1071.05;220.085;2662.07 0 Exp 2,1(0.25);Poly 2,2(0.5);Power,1(0.25) 1.6504697994458548 6.641868591308594 1.5021449327468872 1.9814788103103638 0.21796464758791956 1.5791224241256714 310.4369538661275 1093.7355461338725 169.6610071255546 762.5062928744455 457.92588603456966 2634.1066139654304 DOWN 0.25 0.75 0.0 GO:0031347 6 regulation of defense response 154 164 12 12 9 9 8 8 60 156 2323 0.97192 0.06755 0.077718 4.88 688621;295703;25682;259241;316351;24232;29221;81639 tslp;serping1;ppard;nr1d2;npas2;c3;arg1;alox15 TSLP_32811;SERPING1_32597;PPARD_9536;NR1D2_9358;NPAS2_9350;C3_8175;ARG1_33267;ALOX15_8036 285.4934625 164.4332 21.0878 316.24662067480057 316.2323625876372 327.3884648983627 159.27350875 83.45859999999999 3.35457 178.67580004343233 179.19003952682883 184.55213595513857 870.2781124999999 354.46 43.5624 1123.7466983204959 954.1872353174491 1173.779448159469 344.675;32.3997;94.1074;29.1728;21.0878;234.759;760.927;766.819 244.2;13.7308;37.7692;3.35457;11.3305;129.148;413.607;421.048 560.435;99.4885;148.485;114.038;43.5624;694.216;2639.93;2662.07 1 7 1 259241 NR1D2_9358 29.1728 29.1728 3.35457 3.35457 114.038 114.038 29.1728 3.35457 114.038 7 688621;295703;25682;316351;24232;29221;81639 TSLP_32811;SERPING1_32597;PPARD_9536;NPAS2_9350;C3_8175;ARG1_33267;ALOX15_8036 322.1107 234.759 322.7479509406321 181.54764285714285 129.148 180.59698033449928 978.3124142857143 560.435 1168.050192529785 344.675;32.3997;94.1074;21.0878;234.759;760.927;766.819 244.2;13.7308;37.7692;11.3305;129.148;413.607;421.048 560.435;99.4885;148.485;43.5624;694.216;2639.93;2662.07 0 Exp 2,3(0.38);Exp 4,3(0.38);Exp 5,1(0.13);Poly 2,1(0.13) 1.8427567235127846 15.172454237937927 1.5021449327468872 3.0844674110412598 0.5338985339394388 1.7020898461341858 66.34573509364827 504.64118990635166 35.45749630225025 283.0895211977498 91.56137999595217 1648.9948450040476 DOWN 0.125 0.875 0.0 GO:1901740 7 negative regulation of myoblast fusion 3 3 1 1 1 1 1 1 67 2 2477 0.99793 0.078005 0.078005 33.33 245920 cxcl10 CXCL10_8408 670.528 670.528 670.528 670.528 374.802 374.802 374.802 374.802 1955.3 1955.3 1955.3 1955.2999999999997 0.0 670.528 0.0 670.528 670.528 374.802 1955.3 0 1 0 1 245920 CXCL10_8408 670.528 670.528 374.802 374.802 1955.3 1955.3 670.528 374.802 1955.3 0 Exp 2,1(1) 1.8538048267364502 1.8538048267364502 1.8538048267364502 1.8538048267364502 0.0 1.8538048267364502 670.528 670.528 374.802 374.802 1955.3 1955.3 DOWN 0.0 1.0 0.0 GO:0032268 6 regulation of cellular protein metabolic process 600 637 37 34 20 19 14 14 54 623 1856 0.24201 0.8403 0.47818 2.2 688621;24832;295703;81687;24426;25283;24367;361921;24854;114494;29397;24232;29657;81639 tslp;thy1;serping1;mmp9;gstp1;gclc;fgg;ect2;clu;ccna2;ccl11;c3;arntl;alox15 TSLP_32811;THY1_33010;SERPING1_32597;MMP9_32531;GSTP1_8762;GCLC_8699;FGG_8639;ECT2_8523;CLU_32773;CCNA2_8221;CCL11_33230;C3_8175;ARNTL_8086;ALOX15_8036 304.66654285714327 87.08059999999999 5.72311E-12 378.52813290365077 319.622024812863 373.31253023467593 193.0219614285718 30.2791 5.72311E-12 261.6880768407298 197.66085351183386 252.94012454766946 716.0215428571433 248.34875 5.72313E-12 927.0281599012094 773.1157327900078 945.1622579657977 344.675;5.72311E-12;32.3997;728.316;14.7631;131.7;42.4612;10.0162;935.649;14.384;986.476;234.759;22.9134;766.819 244.2;5.72311E-12;13.7308;443.137;9.42992;39.9158;20.6424;3.29405;808.484;4.89199;552.974;129.148;11.4115;421.048 560.435;5.72313E-12;99.4885;2039.06;25.7196;397.209;98.0534;37.7305;1071.05;58.2504;2230.86;694.216;50.1592;2662.07 2 12 2 24426;29397 GSTP1_8762;CCL11_33230 500.61955 500.61955 687.1047809564456 281.20196000000004 281.20196000000004 384.3437048418033 1128.2898 1128.2898 1559.2697303084162 14.7631;986.476 9.42992;552.974 25.7196;2230.86 12 688621;24832;295703;81687;25283;24367;361921;24854;114494;24232;29657;81639 TSLP_32811;THY1_33010;SERPING1_32597;MMP9_32531;GCLC_8699;FGG_8639;ECT2_8523;CLU_32773;CCNA2_8221;C3_8175;ARNTL_8086;ALOX15_8036 272.0077083333338 87.08059999999999 343.90521692288013 178.32529500000047 30.2791 256.6187537415991 647.3101666666671 248.34875 870.9476739360366 344.675;5.72311E-12;32.3997;728.316;131.7;42.4612;10.0162;935.649;14.384;234.759;22.9134;766.819 244.2;5.72311E-12;13.7308;443.137;39.9158;20.6424;3.29405;808.484;4.89199;129.148;11.4115;421.048 560.435;5.72313E-12;99.4885;2039.06;397.209;98.0534;37.7305;1071.05;58.2504;694.216;50.1592;2662.07 0 Exp 2,2(0.15);Exp 4,6(0.43);Hill,2(0.15);Linear,1(0.08);Poly 2,2(0.15);Power,1(0.08) 1.9802184101819142 28.93010139465332 1.5021449327468872 3.5281898975372314 0.6876933504058577 1.790760576725006 106.38138101584627 502.95170469844027 55.941363824722146 330.1025590324215 230.41449614328934 1201.6285895709973 DOWN 0.14285714285714285 0.8571428571428571 0.0 GO:0006529 7 asparagine biosynthetic process 1 1 1 1 1 1 1 1 67 0 2479 1.0 0.026698 0.026698 100.0 25612 asns ASNS_8091 191.145 191.145 191.145 191.145 113.564 113.564 113.564 113.564 510.267 510.267 510.267 510.267 0.0 191.145 0.0 191.145 191.145 113.564 510.267 0 1 0 1 25612 ASNS_8091 191.145 191.145 113.564 113.564 510.267 510.267 191.145 113.564 510.267 0 Poly 2,1(1) 1.805381178855896 1.805381178855896 1.805381178855896 1.805381178855896 0.0 1.805381178855896 191.145 191.145 113.564 113.564 510.267 510.267 DOWN 0.0 1.0 0.0 GO:0070981 7 L-asparagine biosynthetic process 1 1 1 1 1 1 1 1 67 0 2479 1.0 0.026698 0.026698 100.0 25612 asns ASNS_8091 191.145 191.145 191.145 191.145 113.564 113.564 113.564 113.564 510.267 510.267 510.267 510.267 0.0 191.145 0.0 191.145 191.145 113.564 510.267 0 1 0 1 25612 ASNS_8091 191.145 191.145 113.564 113.564 510.267 510.267 191.145 113.564 510.267 0 Poly 2,1(1) 1.805381178855896 1.805381178855896 1.805381178855896 1.805381178855896 0.0 1.805381178855896 191.145 191.145 113.564 113.564 510.267 510.267 DOWN 0.0 1.0 0.0 GO:0070982 7 L-asparagine metabolic process 1 1 1 1 1 1 1 1 67 0 2479 1.0 0.026698 0.026698 100.0 25612 asns ASNS_8091 191.145 191.145 191.145 191.145 113.564 113.564 113.564 113.564 510.267 510.267 510.267 510.267 0.0 191.145 0.0 191.145 191.145 113.564 510.267 0 1 0 1 25612 ASNS_8091 191.145 191.145 113.564 113.564 510.267 510.267 191.145 113.564 510.267 0 Poly 2,1(1) 1.805381178855896 1.805381178855896 1.805381178855896 1.805381178855896 0.0 1.805381178855896 191.145 191.145 113.564 113.564 510.267 510.267 DOWN 0.0 1.0 0.0 GO:0031328 7 positive regulation of cellular biosynthetic process 404 436 23 22 16 13 11 11 57 425 2054 0.49541 0.63375 1.0 2.52 360243;25671;25682;25154;362282;259241;316351;24854;306575;114494;29657 top2a;smad1;ppard;pgr;pck1;nr1d2;npas2;clu;ckap2;ccna2;arntl TOP2A_10059;SMAD1_32578;PPARD_9536;PGR_32824;PCK1_9439;NR1D2_9358;NPAS2_9350;CLU_32773;CKAP2_8324;CCNA2_8221;ARNTL_8086 188.2546 32.2386 14.384 294.28042996457987 148.18829053684965 275.0591962262177 129.07406545454543 15.2683 3.35457 248.93418190533166 100.96998640794304 238.38655234571476 407.2672090909091 114.038 43.5624 538.9528164859266 302.41718594295685 448.49975480180655 86.3883;21.9973;94.1074;283.618;529.244;29.1728;21.0878;935.649;32.2386;14.384;22.9134 26.6888;5.02186;37.7692;138.711;356.883;3.35457;11.3305;808.484;15.2683;4.89199;11.4115 262.273;80.1461;148.485;1554.21;1021.06;114.038;43.5624;1071.05;76.7052;58.2504;50.1592 2 9 2 362282;259241 PCK1_9439;NR1D2_9358 279.20840000000004 279.20840000000004 353.6037365960942 180.118785 180.118785 249.98235019523364 567.549 567.549 641.3614068853847 529.244;29.1728 356.883;3.35457 1021.06;114.038 9 360243;25671;25682;25154;316351;24854;306575;114494;29657 TOP2A_10059;SMAD1_32578;PPARD_9536;PGR_32824;NPAS2_9350;CLU_32773;CKAP2_8324;CCNA2_8221;ARNTL_8086 168.04264444444445 32.2386 300.1566708136274 117.73079444444446 15.2683 262.3980608821761 371.64903333333336 80.1461 551.1985276135088 86.3883;21.9973;94.1074;283.618;21.0878;935.649;32.2386;14.384;22.9134 26.6888;5.02186;37.7692;138.711;11.3305;808.484;15.2683;4.89199;11.4115 262.273;80.1461;148.485;1554.21;43.5624;1071.05;76.7052;58.2504;50.1592 0 Exp 4,7(0.64);Exp 5,1(0.1);Linear,1(0.1);Poly 2,2(0.19) 1.9890279442277554 22.69414246082306 1.5405861139297485 3.442979335784912 0.6363979442319282 1.9388991594314575 14.345979281775953 362.163220718224 -18.036635144833156 276.184766053924 88.76644790012608 725.7679702816921 DOWN 0.18181818181818182 0.8181818181818182 0.0 GO:0014045 6 establishment of endothelial blood-brain barrier 1 1 1 1 1 1 1 1 67 0 2479 1.0 0.026698 0.026698 100.0 24646 abcb1b ABCB1B_7939 20.7941 20.7941 20.7941 20.7941 8.25355 8.25355 8.25355 8.25355 57.2115 57.2115 57.2115 57.2115 0.0 20.7941 0.0 20.7941 20.7941 8.25355 57.2115 0 1 0 1 24646 ABCB1B_7939 20.7941 20.7941 8.25355 8.25355 57.2115 57.2115 20.7941 8.25355 57.2115 0 Hill,1(1) 6.191005229949951 6.191005229949951 6.191005229949951 6.191005229949951 0.0 6.191005229949951 20.7941 20.7941 8.25355 8.25355 57.2115 57.2115 DOWN 0.0 1.0 0.0 GO:0051716 3 cellular response to stimulus 785 838 67 66 48 47 38 38 30 800 1679 0.99998 6.4447E-5 1.0971E-4 4.53 116669;684352;360243;25671;25682;299112;288583;363131;25154;362282;300795;338475;24314;313108;81687;291234;316273;293502;24426;25283;24367;25315;361921;312495;24296;245920;84032;24854;113902;114494;29397;246142;25612;29657;29221;81639;24646;170913 vwf;twf2;top2a;smad1;ppard;pole2;plod3;pik3r4;pgr;pck1;pclaf;nrep;nqo1;mms22l;mmp9;mki67;mcm3;kif22;gstp1;gclc;fgg;ephx1;ect2;cyp26b1;cyp1a1;cxcl10;col3a1;clu;ces1d;ccna2;ccl11;bmf;asns;arntl;arg1;alox15;abcb1b;abcb1a VWF_32396;TWF2_10109;TOP2A_10059;SMAD1_32578;PPARD_9536;POLE2_9520;PLOD3_9507;PIK3R4_9484;PGR_32824;PCK1_9439;NS5ATP9_9367;NREP_9364;NQO1_33055;MMS22L_33129;MMP9_32531;MKI67_9232;MCM3_9207;KIF22_8963;GSTP1_8762;GCLC_8699;FGG_8639;EPHX1_8567;ECT2_8523;CYP26B1_8418;CYP1A1_8415;CXCL10_8408;COL3A1_8354;CLU_32773;CES1D_32914;CCNA2_8221;CCL11_33230;BMF_8152;ASNS_8091;ARNTL_8086;ARG1_33267;ALOX15_8036;ABCB1B_7939;ABCB1A_7938 254.51453948083153 106.7542 2.71598E-7 325.92644011619336 201.20830214700496 295.24343005504085 157.92409263872628 38.8425 2.71598E-7 225.4214917260357 119.85479054815265 196.17502351751514 655.3163605334631 230.2855 2.71599E-7 810.17826283988 559.1334065424036 798.5651166711069 19.6764;138.399;86.3883;21.9973;94.1074;2.71598E-7;882.629;955.628;283.618;529.244;292.216;61.543;25.6813;126.653;728.316;21.9311;197.273;17.3097;14.7631;131.7;42.4612;39.2381;10.0162;18.1872;12.8863;670.528;212.603;935.649;11.0684;14.384;986.476;119.401;191.145;22.9134;760.927;766.819;20.7941;206.982 4.11644;90.7363;26.6888;5.02186;37.7692;2.71598E-7;625.677;735.228;138.711;356.883;147.515;25.6719;7.73944;85.587;443.137;6.82654;116.413;3.12114;9.42992;39.9158;20.6424;18.9587;3.29405;10.0176;9.13136;374.802;119.81;808.484;4.18343;4.89199;552.974;81.8286;113.564;11.4115;413.607;421.048;8.25355;118.025 94.078;299.165;262.273;80.1461;148.485;2.71599E-7;1106.02;1288.97;1554.21;1021.06;658.494;148.788;86.1211;240.486;2039.06;76.1794;496.915;90.6321;25.7196;397.209;98.0534;81.6965;37.7305;36.7271;19.3234;1955.3;1510.69;1071.05;17.0564;58.2504;2230.86;220.085;510.267;50.1592;2639.93;2662.07;57.2115;1531.55 7 31 7 362282;24314;24426;25315;312495;24296;29397 PCK1_9439;NQO1_33055;GSTP1_8762;EPHX1_8567;CYP26B1_8418;CYP1A1_8415;CCL11_33230 232.3537142857143 25.6813 382.5855695287588 137.87628857142857 10.0176 223.89305943798138 500.21538571428573 81.6965 845.0115158906168 529.244;25.6813;14.7631;39.2381;18.1872;12.8863;986.476 356.883;7.73944;9.42992;18.9587;10.0176;9.13136;552.974 1021.06;86.1211;25.7196;81.6965;36.7271;19.3234;2230.86 31 116669;684352;360243;25671;25682;299112;288583;363131;25154;300795;338475;313108;81687;291234;316273;293502;25283;24367;361921;245920;84032;24854;113902;114494;246142;25612;29657;29221;81639;24646;170913 VWF_32396;TWF2_10109;TOP2A_10059;SMAD1_32578;PPARD_9536;POLE2_9520;PLOD3_9507;PIK3R4_9484;PGR_32824;NS5ATP9_9367;NREP_9364;MMS22L_33129;MMP9_32531;MKI67_9232;MCM3_9207;KIF22_8963;GCLC_8699;FGG_8639;ECT2_8523;CXCL10_8408;COL3A1_8354;CLU_32773;CES1D_32914;CCNA2_8221;BMF_8152;ASNS_8091;ARNTL_8086;ARG1_33267;ALOX15_8036;ABCB1B_7939;ABCB1A_7938 259.5185967829547 126.653 318.74720181856765 162.45101613779352 81.8286 229.19657595129073 690.3391612990838 262.273 812.3156364772258 19.6764;138.399;86.3883;21.9973;94.1074;2.71598E-7;882.629;955.628;283.618;292.216;61.543;126.653;728.316;21.9311;197.273;17.3097;131.7;42.4612;10.0162;670.528;212.603;935.649;11.0684;14.384;119.401;191.145;22.9134;760.927;766.819;20.7941;206.982 4.11644;90.7363;26.6888;5.02186;37.7692;2.71598E-7;625.677;735.228;138.711;147.515;25.6719;85.587;443.137;6.82654;116.413;3.12114;39.9158;20.6424;3.29405;374.802;119.81;808.484;4.18343;4.89199;81.8286;113.564;11.4115;413.607;421.048;8.25355;118.025 94.078;299.165;262.273;80.1461;148.485;2.71599E-7;1106.02;1288.97;1554.21;658.494;148.788;240.486;2039.06;76.1794;496.915;90.6321;397.209;98.0534;37.7305;1955.3;1510.69;1071.05;17.0564;58.2504;220.085;510.267;50.1592;2639.93;2662.07;57.2115;1531.55 0 Exp 2,4(0.11);Exp 4,12(0.32);Exp 5,2(0.06);Hill,6(0.16);Linear,2(0.06);Poly 2,11(0.29);Power,1(0.03) 2.0202544956424613 89.85641479492188 1.5018656253814697 15.48720932006836 2.3397742164514552 1.800019919872284 150.8849288933426 358.1441500683205 86.25043094594692 229.5977543315056 397.71695296587313 912.9157681010533 DOWN 0.18421052631578946 0.8157894736842105 0.0 GO:0022607 5 cellular component assembly 355 395 22 22 14 17 10 10 58 385 2094 0.50875 0.62608 1.0 2.53 24832;25671;288583;316273;24367;309186;361921;24854;113902;686019 thy1;smad1;plod3;mcm3;fgg;fermt3;ect2;clu;ces1d;casq1 THY1_33010;SMAD1_32578;PLOD3_9507;MCM3_9207;FGG_8639;FERMT3_32542;ECT2_8523;CLU_32773;CES1D_32914;CASQ1_32992 278.7867100000006 95.0606 5.72311E-12 369.853621715926 229.82014577302974 331.8931399505038 201.45660400000057 58.62235 5.72311E-12 293.3249714108809 167.5202264388376 270.29137975649155 438.06044000000054 191.91320000000002 5.72313E-12 495.4025674284207 369.4501621403859 447.0956043441412 5.72311E-12;21.9973;882.629;197.273;42.4612;539.113;10.0162;935.649;11.0684;147.66 5.72311E-12;5.02186;625.677;116.413;20.6424;334.248;3.29405;808.484;4.18343;96.6023 5.72313E-12;80.1461;1106.02;496.915;98.0534;1187.86;37.7305;1071.05;17.0564;285.773 0 10 0 10 24832;25671;288583;316273;24367;309186;361921;24854;113902;686019 THY1_33010;SMAD1_32578;PLOD3_9507;MCM3_9207;FGG_8639;FERMT3_32542;ECT2_8523;CLU_32773;CES1D_32914;CASQ1_32992 278.7867100000006 95.0606 369.853621715926 201.45660400000057 58.62235 293.3249714108809 438.06044000000054 191.91320000000002 495.4025674284207 5.72311E-12;21.9973;882.629;197.273;42.4612;539.113;10.0162;935.649;11.0684;147.66 5.72311E-12;5.02186;625.677;116.413;20.6424;334.248;3.29405;808.484;4.18343;96.6023 5.72313E-12;80.1461;1106.02;496.915;98.0534;1187.86;37.7305;1071.05;17.0564;285.773 0 Exp 2,1(0.1);Exp 4,3(0.3);Exp 5,1(0.1);Hill,1(0.1);Poly 2,4(0.4) 1.8142240036995976 18.479518175125122 1.5548590421676636 2.8176381587982178 0.40791718254912446 1.6817947626113892 49.54906028501128 508.02435971498994 19.651903164617778 383.2613048353834 131.00674753328553 745.1141324667155 DOWN 0.0 1.0 0.0 GO:0002684 5 positive regulation of immune system process 239 264 18 18 10 12 7 7 61 257 2222 0.59139 0.56801 1.0 2.65 688621;24832;295703;81687;245920;24232;29221 tslp;thy1;serping1;mmp9;cxcl10;c3;arg1 TSLP_32811;THY1_33010;SERPING1_32597;MMP9_32531;CXCL10_8408;C3_8175;ARG1_33267 395.9435285714294 344.675 5.72311E-12 325.7364306490576 442.9477617830409 320.1324812946111 231.2321142857151 244.2 5.72311E-12 187.1456814246351 264.4814642312387 184.01419415411533 1141.2042142857151 694.216 5.72313E-12 1051.9573797679031 1253.5820820477109 1073.3641648938863 344.675;5.72311E-12;32.3997;728.316;670.528;234.759;760.927 244.2;5.72311E-12;13.7308;443.137;374.802;129.148;413.607 560.435;5.72313E-12;99.4885;2039.06;1955.3;694.216;2639.93 0 7 0 7 688621;24832;295703;81687;245920;24232;29221 TSLP_32811;THY1_33010;SERPING1_32597;MMP9_32531;CXCL10_8408;C3_8175;ARG1_33267 395.9435285714294 344.675 325.7364306490576 231.2321142857151 244.2 187.1456814246351 1141.2042142857151 694.216 1051.9573797679031 344.675;5.72311E-12;32.3997;728.316;670.528;234.759;760.927 244.2;5.72311E-12;13.7308;443.137;374.802;129.148;413.607 560.435;5.72313E-12;99.4885;2039.06;1955.3;694.216;2639.93 0 Exp 2,3(0.43);Exp 4,1(0.15);Hill,1(0.15);Linear,1(0.15);Poly 2,1(0.15) 1.7387903174718156 12.232921242713928 1.513624906539917 2.05134654045105 0.19002422541597966 1.7183171510696411 154.63460380508104 637.2524533377778 92.59265332870993 369.87157524272027 361.90328160831484 1920.5051469631153 DOWN 0.0 1.0 0.0 GO:0042391 4 regulation of membrane potential 94 95 6 6 3 4 3 3 65 92 2387 0.75323 0.46981 0.73978 3.16 25283;170945;81639 gclc;chrna2;alox15 GCLC_8699;CHRNA2_32401;ALOX15_8036 353.99933333333337 163.479 131.7 357.86524572851897 288.12063406010606 318.3402783414854 187.64393333333336 101.968 39.9158 204.50113113040064 150.18795948506414 182.9402434584664 1157.8803333333333 414.362 397.209 1302.6946961327253 918.3055773083723 1157.986041595109 131.7;163.479;766.819 39.9158;101.968;421.048 397.209;414.362;2662.07 0 3 0 3 25283;170945;81639 GCLC_8699;CHRNA2_32401;ALOX15_8036 353.99933333333337 163.479 357.86524572851897 187.64393333333336 101.968 204.50113113040064 1157.8803333333333 414.362 1302.6946961327253 131.7;163.479;766.819 39.9158;101.968;421.048 397.209;414.362;2662.07 0 Exp 2,1(0.34);Hill,1(0.34);Poly 2,1(0.34) 1.7473678704278561 5.275466680526733 1.5021449327468872 1.9746891260147095 0.23881612767256005 1.7986326217651367 -50.963314738411896 758.9619814050785 -43.77088155779745 419.0587482244641 -316.25748829555505 2632.018154962222 DOWN 0.0 1.0 0.0 GO:0051248 7 negative regulation of protein metabolic process 294 313 19 17 11 9 7 7 61 306 2173 0.39012 0.74887 0.71137 2.24 24832;295703;81687;24426;25283;24854;24232 thy1;serping1;mmp9;gstp1;gclc;clu;c3 THY1_33010;SERPING1_32597;MMP9_32531;GSTP1_8762;GCLC_8699;CLU_32773;C3_8175 296.7981142857151 131.7 5.72311E-12 379.25008686327396 331.0777632585528 376.8146311505687 206.26364571428653 39.9158 5.72311E-12 308.42445684344534 218.45691562004836 300.0468440765119 618.1061571428579 397.209 5.72313E-12 739.4589845970759 744.7815339952273 807.7809573795806 5.72311E-12;32.3997;728.316;14.7631;131.7;935.649;234.759 5.72311E-12;13.7308;443.137;9.42992;39.9158;808.484;129.148 5.72313E-12;99.4885;2039.06;25.7196;397.209;1071.05;694.216 1 6 1 24426 GSTP1_8762 14.7631 14.7631 9.42992 9.42992 25.7196 25.7196 14.7631 9.42992 25.7196 6 24832;295703;81687;25283;24854;24232 THY1_33010;SERPING1_32597;MMP9_32531;GCLC_8699;CLU_32773;C3_8175 343.80395000000095 183.22949999999997 392.4748984290514 239.06926666666763 84.5319 324.20768198796605 716.837250000001 545.7125 757.8111551229457 5.72311E-12;32.3997;728.316;131.7;935.649;234.759 5.72311E-12;13.7308;443.137;39.9158;808.484;129.148 5.72313E-12;99.4885;2039.06;397.209;1071.05;694.216 0 Exp 4,2(0.29);Hill,2(0.29);Linear,1(0.15);Poly 2,2(0.29) 1.9572781062329452 14.237367033958435 1.5467612743377686 3.5281898975372314 0.6870500518005479 1.863204002380371 15.845718214552335 577.7505103568778 -22.2203893819337 434.7476808105067 70.30727530952083 1165.905038976195 DOWN 0.14285714285714285 0.8571428571428571 0.0 GO:0007596 5 blood coagulation 27 28 5 5 4 5 4 4 64 24 2455 0.99929 0.0058691 0.0058691 14.29 116669;295703;29243;24232 vwf;serping1;f10;c3 VWF_32396;SERPING1_32597;F10_8585;C3_8175 97.75627499999999 68.29485 19.6764 98.62232379224544 69.49718367223979 81.69632678318635 46.354535 26.07685 4.11644 57.05562617615286 29.651040445850278 45.73585980625347 262.70662500000003 131.26625 94.078 289.3721646557638 185.70168579605362 221.29834423386862 0.5 26.038050000000002 1.5 68.29485 19.6764;32.3997;104.19;234.759 4.11644;13.7308;38.4229;129.148 94.078;99.4885;163.044;694.216 0 4 0 4 116669;295703;29243;24232 VWF_32396;SERPING1_32597;F10_8585;C3_8175 97.75627499999999 68.29485 98.62232379224544 46.354535 26.07685 57.05562617615286 262.70662500000003 131.26625 289.3721646557638 19.6764;32.3997;104.19;234.759 4.11644;13.7308;38.4229;129.148 94.078;99.4885;163.044;694.216 0 Exp 4,1(0.25);Exp 5,1(0.25);Hill,1(0.25);Poly 2,1(0.25) 1.7055902399779206 6.878870248794556 1.5225032567977905 2.0912885665893555 0.2625987637827004 1.6325392127037048 1.106397683599468 194.40615231640055 -9.559978652629809 102.2690486526298 -20.878096362648478 546.2913463626485 DOWN 0.0 1.0 0.0 GO:0000165 8 MAPK cascade 43 45 3 3 2 3 2 2 66 43 2436 0.88316 0.33942 0.33942 4.44 25671;29397 smad1;ccl11 SMAD1_32578;CCL11_33230 504.23665 504.23665 21.9973 681.9894290799858 800.3061875375375 538.3263315698596 278.99793 278.99793 5.02186 387.4606739596805 447.2047931297965 305.84093293304875 1155.50305 1155.50305 80.1461 1520.7843830821666 1815.7155251418085 1200.4266388084116 21.9973;986.476 5.02186;552.974 80.1461;2230.86 1 1 1 29397 CCL11_33230 986.476 986.476 552.974 552.974 2230.86 2230.86 986.476 552.974 2230.86 1 25671 SMAD1_32578 21.9973 21.9973 5.02186 5.02186 80.1461 80.1461 21.9973 5.02186 80.1461 0 Exp 4,1(0.5);Power,1(0.5) 1.8316851840615647 3.674694299697876 1.6932154893875122 1.9814788103103638 0.20383294899190232 1.837347149848938 -440.9524759999999 1449.4257759999998 -257.9951672 815.9910272000002 -952.1965720000001 3263.2026720000003 CONFLICT 0.5 0.5 0.0 GO:0098542 4 defense response to other organism 155 169 14 14 7 10 6 6 62 163 2316 0.83896 0.29479 0.45381 3.55 688621;295703;304545;245920;24232;29221 tslp;serping1;oasl;cxcl10;c3;arg1 TSLP_32811;SERPING1_32597;OASL_9389;CXCL10_8408;C3_8175;ARG1_33267 353.31688333333335 289.717 32.3997 303.46421619939593 390.8733655755432 296.42341009275134 200.65591666666668 186.67399999999998 13.7308 171.62817991279192 229.18170442347392 163.60175134561757 1034.95975 627.3254999999999 99.4885 1023.6505289417744 1117.2401156001179 1092.4075974532093 344.675;32.3997;76.6126;670.528;234.759;760.927 244.2;13.7308;28.4477;374.802;129.148;413.607 560.435;99.4885;260.389;1955.3;694.216;2639.93 0 6 0 6 688621;295703;304545;245920;24232;29221 TSLP_32811;SERPING1_32597;OASL_9389;CXCL10_8408;C3_8175;ARG1_33267 353.31688333333335 289.717 303.46421619939593 200.65591666666668 186.67399999999998 171.62817991279192 1034.95975 627.3254999999999 1023.6505289417744 344.675;32.3997;76.6126;670.528;234.759;760.927 244.2;13.7308;28.4477;374.802;129.148;413.607 560.435;99.4885;260.389;1955.3;694.216;2639.93 0 Exp 2,3(0.5);Exp 4,2(0.34);Poly 2,1(0.17) 1.695979060692184 10.211114645004272 1.513624906539917 1.8927439451217651 0.15462130005647642 1.7020898461341858 110.49493827182872 596.138828394838 63.32477101881628 337.98706231451706 215.86873619309915 1854.0507638069007 DOWN 0.0 1.0 0.0 GO:0009617 5 response to bacterium 110 127 11 11 6 8 5 5 63 122 2357 0.87978 0.2494 0.38682 3.94 688621;362282;362376;245920;24232 tslp;pck1;herc6;cxcl10;c3 TSLP_32811;PCK1_9439;HERC6_8794;CXCL10_8408;C3_8175 363.7785 344.675 39.6865 246.73907625110783 275.4969282674772 216.68233346088803 224.16117999999997 244.2 15.7729 152.61264043031304 175.87781879635256 140.9686332966163 877.6836 694.216 157.407 677.2959679093772 609.435625775076 541.1669383468565 344.675;529.244;39.6865;670.528;234.759 244.2;356.883;15.7729;374.802;129.148 560.435;1021.06;157.407;1955.3;694.216 1 4 1 362282 PCK1_9439 529.244 529.244 356.883 356.883 1021.06 1021.06 529.244 356.883 1021.06 4 688621;362376;245920;24232 TSLP_32811;HERC6_8794;CXCL10_8408;C3_8175 322.412125 289.717 264.1320044877735 190.980725 186.67399999999998 153.9952598797633 841.8395 627.3254999999999 776.5786765226475 344.675;39.6865;670.528;234.759 244.2;15.7729;374.802;129.148 560.435;157.407;1955.3;694.216 0 Exp 2,2(0.4);Exp 4,1(0.2);Linear,1(0.2);Poly 2,1(0.2) 1.6914545976760567 8.475242614746094 1.5467612743377686 1.8538048267364502 0.12354557724328143 1.6858625411987305 147.50216389643145 580.0548361035685 90.39030261465825 357.9320573853417 284.00750854830187 1471.3596914516984 DOWN 0.2 0.8 0.0 GO:0001503 3 ossification 29 30 6 5 2 3 2 2 66 28 2451 0.95581 0.19005 0.19005 6.67 81687;81639 mmp9;alox15 MMP9_32531;ALOX15_8036 747.5675 747.5675 728.316 27.22573239602119 744.7549672033393 26.93361882546416 432.0925 432.0925 421.048 15.619281689631185 433.7060375670841 15.45169743229536 2350.565 2350.565 2039.06 440.5345957470303 2305.0559212880144 435.8079594954315 0.5 747.5675 728.316;766.819 443.137;421.048 2039.06;2662.07 0 2 0 2 81687;81639 MMP9_32531;ALOX15_8036 747.5675 747.5675 27.22573239602119 432.0925 432.0925 15.619281689631185 2350.565 2350.565 440.5345957470303 728.316;766.819 443.137;421.048 2039.06;2662.07 0 Exp 2,1(0.5);Linear,1(0.5) 1.7553973370853682 3.553491473197937 1.5021449327468872 2.05134654045105 0.3883441810461674 1.7767457365989685 709.83456 785.30044 410.44527999999997 453.73972 1740.0151999999998 2961.1148000000003 DOWN 0.0 1.0 0.0 GO:0001523 8 retinoid metabolic process 16 19 4 4 4 4 4 4 64 15 2464 0.9999 0.0013315 0.0013315 21.05 25682;312495;24296;113902 ppard;cyp26b1;cyp1a1;ces1d PPARD_9536;CYP26B1_8418;CYP1A1_8415;CES1D_32914 34.062325 15.536750000000001 11.0684 40.14380503152593 35.6997356123508 39.683148955203876 15.2753975 9.574480000000001 4.18343 15.213990549079874 16.29768772573949 14.681595984294395 55.397975 28.02525 17.0564 62.677074840081424 59.412010690192005 61.01541149456654 0.0 11.0684 0.5 11.977350000000001 94.1074;18.1872;12.8863;11.0684 37.7692;10.0176;9.13136;4.18343 148.485;36.7271;19.3234;17.0564 2 2 2 312495;24296 CYP26B1_8418;CYP1A1_8415 15.536750000000001 15.536750000000001 3.7483023363917627 9.574480000000001 9.574480000000001 0.6266663137587598 28.02525 28.02525 12.306274287736318 18.1872;12.8863 10.0176;9.13136 36.7271;19.3234 2 25682;113902 PPARD_9536;CES1D_32914 52.5879 52.5879 58.717440002949715 20.976315 20.976315 23.748725718371716 82.7707 82.7707 92.9340543018543 94.1074;11.0684 37.7692;4.18343 148.485;17.0564 0 Exp 4,2(0.5);Exp 5,2(0.5) 3.1789292864234624 21.143412113189697 1.6269687414169312 15.48720932006836 6.803639731163843 2.0146170258522034 -5.278603930895407 73.4032539308954 0.36568676190172766 30.185108238098273 -6.025558343279791 116.82150834327979 CONFLICT 0.5 0.5 0.0 GO:0046946 8 hydroxylysine metabolic process 2 2 1 1 1 1 1 1 67 1 2478 0.9993 0.052694 0.052694 50.0 288583 plod3 PLOD3_9507 882.629 882.629 882.629 882.629 625.677 625.677 625.677 625.677 1106.02 1106.02 1106.02 1106.02 0.0 882.629 0.0 882.629 882.629 625.677 1106.02 0 1 0 1 288583 PLOD3_9507 882.629 882.629 625.677 625.677 1106.02 1106.02 882.629 625.677 1106.02 0 Poly 2,1(1) 1.7160688638687134 1.7160688638687134 1.7160688638687134 1.7160688638687134 0.0 1.7160688638687134 882.629 882.629 625.677 625.677 1106.02 1106.02 DOWN 0.0 1.0 0.0 GO:0046947 8 hydroxylysine biosynthetic process 2 2 1 1 1 1 1 1 67 1 2478 0.9993 0.052694 0.052694 50.0 288583 plod3 PLOD3_9507 882.629 882.629 882.629 882.629 625.677 625.677 625.677 625.677 1106.02 1106.02 1106.02 1106.02 0.0 882.629 0.0 882.629 882.629 625.677 1106.02 0 1 0 1 288583 PLOD3_9507 882.629 882.629 625.677 625.677 1106.02 1106.02 882.629 625.677 1106.02 0 Poly 2,1(1) 1.7160688638687134 1.7160688638687134 1.7160688638687134 1.7160688638687134 0.0 1.7160688638687134 882.629 882.629 625.677 625.677 1106.02 1106.02 DOWN 0.0 1.0 0.0 GO:0061024 5 membrane organization 110 116 8 8 6 5 4 4 64 112 2367 0.8047 0.3751 0.54956 3.45 25283;24854;24646;170913 gclc;clu;abcb1b;abcb1a GCLC_8699;CLU_32773;ABCB1B_7939;ABCB1A_7938 323.781275 169.341 20.7941 415.01832407630206 219.942880599402 337.2084260313901 243.6695875 78.9704 8.25355 379.3583176754144 150.91032892705655 304.3411052350973 764.2551249999999 734.1295 57.2115 662.6960253535522 628.0990418955566 670.0964809088462 131.7;935.649;20.7941;206.982 39.9158;808.484;8.25355;118.025 397.209;1071.05;57.2115;1531.55 0 4 0 4 25283;24854;24646;170913 GCLC_8699;CLU_32773;ABCB1B_7939;ABCB1A_7938 323.781275 169.341 415.01832407630206 243.6695875 78.9704 379.3583176754144 764.2551249999999 734.1295 662.6960253535522 131.7;935.649;20.7941;206.982 39.9158;808.484;8.25355;118.025 397.209;1071.05;57.2115;1531.55 0 Hill,2(0.5);Poly 2,2(0.5) 2.4474178171559084 11.608029842376709 1.5548590421676636 6.191005229949951 2.200114214071571 1.9310827851295471 -82.93668259477602 730.4992325947761 -128.10156382190615 615.440738821906 114.81302015351889 1413.6972298464812 DOWN 0.0 1.0 0.0 GO:0050714 7 positive regulation of protein secretion 92 99 5 5 3 4 3 3 65 96 2383 0.7294 0.49758 0.74653 3.03 688621;25682;24367 tslp;ppard;fgg TSLP_32811;PPARD_9536;FGG_8639 160.41453333333334 94.1074 42.4612 161.6501536521798 165.49590477082484 169.06148321698626 100.87053333333331 37.7692 20.6424 124.4219989823879 106.7840808757244 128.56998013634734 268.9911333333333 148.485 98.0534 253.65425707614946 279.68779704969853 263.2262333876134 344.675;94.1074;42.4612 244.2;37.7692;20.6424 560.435;148.485;98.0534 0 3 0 3 688621;25682;24367 TSLP_32811;PPARD_9536;FGG_8639 160.41453333333334 94.1074 161.6501536521798 100.87053333333331 37.7692 124.4219989823879 268.9911333333333 148.485 253.65425707614946 344.675;94.1074;42.4612 244.2;37.7692;20.6424 560.435;148.485;98.0534 0 Exp 2,1(0.34);Exp 4,1(0.34);Exp 5,1(0.34) 2.096142810550311 6.442399859428406 1.6858625411987305 2.8176381587982178 0.5940154049303563 1.9388991594314575 -22.509835728902203 343.3389023955689 -39.92621289362893 241.66727956029558 -18.045679730525194 556.0279463971918 DOWN 0.0 1.0 0.0 GO:0071705 5 nitrogen compound transport 239 254 14 14 11 12 10 10 58 244 2235 0.92982 0.1338 0.2136 3.94 313089;294881;170551;89776;363131;24367;24854;29657;24646;170913 slc7a13;slc7a12;slc5a6;slc22a7;pik3r4;fgg;clu;arntl;abcb1b;abcb1a SLC7A13_32952;SLC7A12_32838;SLC5A6_9881;SLC22A7_9847;PIK3R4_9484;FGG_8639;CLU_32773;ARNTL_8086;ABCB1B_7939;ABCB1A_7938 278.95036 84.6143 20.7941 370.0981708720845 192.52823011721068 296.83366557481634 209.337095 51.430049999999994 8.25355 308.43416839284134 138.60640785674678 250.9614338010776 527.98661 191.29649999999998 50.1592 569.6772534633126 449.0247676590375 554.9067965267249 397.931;37.9163;120.077;49.1516;955.628;42.4612;935.649;22.9134;20.7941;206.982 280.111;15.3983;82.2177;13.5995;735.228;20.6424;808.484;11.4115;8.25355;118.025 668.129;132.15;221.286;161.307;1288.97;98.0534;1071.05;50.1592;57.2115;1531.55 0 10 0 10 313089;294881;170551;89776;363131;24367;24854;29657;24646;170913 SLC7A13_32952;SLC7A12_32838;SLC5A6_9881;SLC22A7_9847;PIK3R4_9484;FGG_8639;CLU_32773;ARNTL_8086;ABCB1B_7939;ABCB1A_7938 278.95036 84.6143 370.0981708720845 209.337095 51.430049999999994 308.43416839284134 527.98661 191.29649999999998 569.6772534633126 397.931;37.9163;120.077;49.1516;955.628;42.4612;935.649;22.9134;20.7941;206.982 280.111;15.3983;82.2177;13.5995;735.228;20.6424;808.484;11.4115;8.25355;118.025 668.129;132.15;221.286;161.307;1288.97;98.0534;1071.05;50.1592;57.2115;1531.55 0 Exp 2,1(0.1);Exp 4,3(0.3);Hill,2(0.2);Poly 2,4(0.4) 2.2591304144811333 25.098361372947693 1.5018656253814697 6.191005229949951 1.436260470021342 1.9053296446800232 49.56113714767744 508.33958285232256 18.16761685310638 400.50657314689363 174.89699018190993 881.0762298180902 DOWN 0.0 1.0 0.0 GO:0046942 7 carboxylic acid transport 73 76 6 6 5 5 4 4 64 72 2407 0.9499 0.14292 0.14292 5.26 313089;294881;170551;25682 slc7a13;slc7a12;slc5a6;ppard SLC7A13_32952;SLC7A12_32838;SLC5A6_9881;PPARD_9536 162.507925 107.09219999999999 37.9163 160.65087662301286 152.42243715701218 147.33054206072254 103.87405 59.993449999999996 15.3983 120.72871734072496 97.81197406903308 110.33501795835836 292.5125 184.8855 132.15 253.39101637390388 276.2881511868467 232.12770958670208 2.5 259.004 397.931;37.9163;120.077;94.1074 280.111;15.3983;82.2177;37.7692 668.129;132.15;221.286;148.485 0 4 0 4 313089;294881;170551;25682 SLC7A13_32952;SLC7A12_32838;SLC5A6_9881;PPARD_9536 162.507925 107.09219999999999 160.65087662301286 103.87405 59.993449999999996 120.72871734072496 292.5125 184.8855 253.39101637390388 397.931;37.9163;120.077;94.1074 280.111;15.3983;82.2177;37.7692 668.129;132.15;221.286;148.485 0 Exp 2,1(0.25);Exp 4,1(0.25);Exp 5,1(0.25);Poly 2,1(0.25) 1.9120666734874188 7.743980884552002 1.517665982246399 2.3742122650146484 0.3500292492896844 1.9260513186454773 5.070065909447408 319.9457840905526 -14.440092993910469 222.18819299391046 44.18930395357424 540.8356960464257 DOWN 0.0 1.0 0.0 GO:0043903 4 regulation of interspecies interactions between organisms 58 62 8 8 4 5 3 3 65 59 2420 0.91845 0.22854 0.22854 4.84 360243;304545;29221 top2a;oasl;arg1 TOP2A_10059;OASL_9389;ARG1_33267 307.9759666666667 86.3883 76.6126 392.29755291860204 331.14982357152695 398.732005380166 156.24783333333335 28.4477 26.6888 222.8813113134956 167.96435554178714 227.88955085200666 1054.1973333333333 262.273 260.389 1373.2850960249782 1128.91244761118 1401.8073524500996 86.3883;76.6126;760.927 26.6888;28.4477;413.607 262.273;260.389;2639.93 0 3 0 3 360243;304545;29221 TOP2A_10059;OASL_9389;ARG1_33267 307.9759666666667 86.3883 392.29755291860204 156.24783333333335 28.4477 222.8813113134956 1054.1973333333333 262.273 1373.2850960249782 86.3883;76.6126;760.927 26.6888;28.4477;413.607 262.273;260.389;2639.93 0 Exp 2,1(0.34);Exp 4,2(0.67) 1.777515681958723 5.366703391075134 1.513624906539917 1.9603345394134521 0.24077971604557863 1.8927439451217651 -135.95050498210662 751.9024383154399 -95.96611343166626 408.46178009833295 -499.821045600346 2608.2157122670123 DOWN 0.0 1.0 0.0 GO:0009987 2 cellular process 2111 2325 133 130 87 87 63 63 5 2262 217 0.72063 0.44864 0.82957 2.71 116669;286989;684352;315852;688621;360243;24832;295661;25671;313089;294881;170551;89776;291463;25682;299112;288583;363131;25154;362282;300795;338475;259241;24314;313108;81687;291234;316273;293502;362376;24426;156275;25283;81919;84493;24367;309186;25315;361921;64191;312495;24296;245920;84032;24854;306575;170945;113902;297594;114494;29397;686019;24232;246142;116599;25612;29657;29221;81639;26760;252898;24646;170913 vwf;ugt2b7;twf2;ttk;tslp;top2a;thy1;spc25;smad1;slc7a13;slc7a12;slc5a6;slc22a7;ppic;ppard;pole2;plod3;pik3r4;pgr;pck1;pclaf;nrep;nr1d2;nqo1;mms22l;mmp9;mki67;mcm3;kif22;herc6;gstp1;ggt7;gclc;fut1;fmo3;fgg;fermt3;ephx1;ect2;dhcr7;cyp26b1;cyp1a1;cxcl10;col3a1;clu;ckap2;chrna2;ces1d;cdca3;ccna2;ccl11;casq1;c3;bmf;blvra;asns;arntl;arg1;alox15;akr7a3;acox2;abcb1b;abcb1a VWF_32396;UGT2B7_33032;TWF2_10109;TTK_32727;TSLP_32811;TOP2A_10059;THY1_33010;SPC25_9925;SMAD1_32578;SLC7A13_32952;SLC7A12_32838;SLC5A6_9881;SLC22A7_9847;PPIC_9541;PPARD_9536;POLE2_9520;PLOD3_9507;PIK3R4_9484;PGR_32824;PCK1_9439;NS5ATP9_9367;NREP_9364;NR1D2_9358;NQO1_33055;MMS22L_33129;MMP9_32531;MKI67_9232;MCM3_9207;KIF22_8963;HERC6_8794;GSTP1_8762;GGT7_33026;GCLC_8699;FUT1_8668;FMO3_8654;FGG_8639;FERMT3_32542;EPHX1_8567;ECT2_8523;DHCR7_8466;CYP26B1_8418;CYP1A1_8415;CXCL10_8408;COL3A1_8354;CLU_32773;CKAP2_8324;CHRNA2_32401;CES1D_32914;CDCA3_8260;CCNA2_8221;CCL11_33230;CASQ1_32992;C3_8175;BMF_8152;BLVRA_8151;ASNS_8091;ARNTL_8086;ARG1_33267;ALOX15_8036;AKR7A3_8015;ACOX2_32902;ABCB1B_7939;ABCB1A_7938 245.1277254011366 120.077 5.72311E-12 290.81731492282734 197.46506980190594 256.4230940793822 149.25460143288257 50.9087 5.72311E-12 198.22102502950708 116.14732923315377 170.17181143716383 622.0079031789144 262.273 5.72313E-12 734.2428588321613 520.2278025698045 684.8775870158095 19.6764;34.7126;138.399;737.351;344.675;86.3883;5.72311E-12;35.8903;21.9973;397.931;37.9163;120.077;49.1516;628.678;94.1074;2.71598E-7;882.629;955.628;283.618;529.244;292.216;61.543;29.1728;25.6813;126.653;728.316;21.9311;197.273;17.3097;39.6865;14.7631;109.609;131.7;240.861;418.073;42.4612;539.113;39.2381;10.0162;161.702;18.1872;12.8863;670.528;212.603;935.649;32.2386;163.479;11.0684;56.6562;14.384;986.476;147.66;234.759;119.401;415.991;191.145;22.9134;760.927;766.819;52.7573;743.353;20.7941;206.982 4.11644;14.7729;90.7363;446.625;244.2;26.6888;5.72311E-12;11.5744;5.02186;280.111;15.3983;82.2177;13.5995;389.239;37.7692;2.71598E-7;625.677;735.228;138.711;356.883;147.515;25.6719;3.35457;7.73944;85.587;443.137;6.82654;116.413;3.12114;15.7729;9.42992;29.3336;39.9158;78.9726;293.29;20.6424;334.248;18.9587;3.29405;50.9087;10.0176;9.13136;374.802;119.81;808.484;15.2683;101.968;4.18343;22.3266;4.89199;552.974;96.6023;129.148;81.8286;288.048;113.564;11.4115;413.607;421.048;12.408;432.537;8.25355;118.025 94.078;105.024;299.165;2108.09;560.435;262.273;5.72313E-12;124.006;80.1461;668.129;132.15;221.286;161.307;1509.86;148.485;2.71599E-7;1106.02;1288.97;1554.21;1021.06;658.494;148.788;114.038;86.1211;240.486;2039.06;76.1794;496.915;90.6321;157.407;25.7196;346.073;397.209;847.87;712.184;98.0534;1187.86;81.6965;37.7305;481.517;36.7271;19.3234;1955.3;1510.69;1071.05;76.7052;414.362;17.0564;150.565;58.2504;2230.86;285.773;694.216;220.085;720.942;510.267;50.1592;2639.93;2662.07;216.887;2287.79;57.2115;1531.55 10 53 10 286989;362282;259241;24314;24426;25315;312495;24296;29397;26760 UGT2B7_33032;PCK1_9439;NR1D2_9358;NQO1_33055;GSTP1_8762;EPHX1_8567;CYP26B1_8418;CYP1A1_8415;CCL11_33230;AKR7A3_8015 174.31187 31.942700000000002 326.111963935933 99.566949 11.2128 192.95520087005474 393.74567 95.57255 711.531442813871 34.7126;529.244;29.1728;25.6813;14.7631;39.2381;18.1872;12.8863;986.476;52.7573 14.7729;356.883;3.35457;7.73944;9.42992;18.9587;10.0176;9.13136;552.974;12.408 105.024;1021.06;114.038;86.1211;25.7196;81.6965;36.7271;19.3234;2230.86;216.887 53 116669;684352;315852;688621;360243;24832;295661;25671;313089;294881;170551;89776;291463;25682;299112;288583;363131;25154;300795;338475;313108;81687;291234;316273;293502;362376;156275;25283;81919;84493;24367;309186;361921;64191;245920;84032;24854;306575;170945;113902;297594;114494;686019;24232;246142;116599;25612;29657;29221;81639;252898;24646;170913 VWF_32396;TWF2_10109;TTK_32727;TSLP_32811;TOP2A_10059;THY1_33010;SPC25_9925;SMAD1_32578;SLC7A13_32952;SLC7A12_32838;SLC5A6_9881;SLC22A7_9847;PPIC_9541;PPARD_9536;POLE2_9520;PLOD3_9507;PIK3R4_9484;PGR_32824;NS5ATP9_9367;NREP_9364;MMS22L_33129;MMP9_32531;MKI67_9232;MCM3_9207;KIF22_8963;HERC6_8794;GGT7_33026;GCLC_8699;FUT1_8668;FMO3_8654;FGG_8639;FERMT3_32542;ECT2_8523;DHCR7_8466;CXCL10_8408;COL3A1_8354;CLU_32773;CKAP2_8324;CHRNA2_32401;CES1D_32914;CDCA3_8260;CCNA2_8221;CASQ1_32992;C3_8175;BMF_8152;BLVRA_8151;ASNS_8091;ARNTL_8086;ARG1_33267;ALOX15_8036;ACOX2_32902;ABCB1B_7939;ABCB1A_7938 258.48920755229443 138.399 285.1072686798475 158.62963019380385 82.2177 199.59793189723922 665.0762490617284 346.073 737.0567965560841 19.6764;138.399;737.351;344.675;86.3883;5.72311E-12;35.8903;21.9973;397.931;37.9163;120.077;49.1516;628.678;94.1074;2.71598E-7;882.629;955.628;283.618;292.216;61.543;126.653;728.316;21.9311;197.273;17.3097;39.6865;109.609;131.7;240.861;418.073;42.4612;539.113;10.0162;161.702;670.528;212.603;935.649;32.2386;163.479;11.0684;56.6562;14.384;147.66;234.759;119.401;415.991;191.145;22.9134;760.927;766.819;743.353;20.7941;206.982 4.11644;90.7363;446.625;244.2;26.6888;5.72311E-12;11.5744;5.02186;280.111;15.3983;82.2177;13.5995;389.239;37.7692;2.71598E-7;625.677;735.228;138.711;147.515;25.6719;85.587;443.137;6.82654;116.413;3.12114;15.7729;29.3336;39.9158;78.9726;293.29;20.6424;334.248;3.29405;50.9087;374.802;119.81;808.484;15.2683;101.968;4.18343;22.3266;4.89199;96.6023;129.148;81.8286;288.048;113.564;11.4115;413.607;421.048;432.537;8.25355;118.025 94.078;299.165;2108.09;560.435;262.273;5.72313E-12;124.006;80.1461;668.129;132.15;221.286;161.307;1509.86;148.485;2.71599E-7;1106.02;1288.97;1554.21;658.494;148.788;240.486;2039.06;76.1794;496.915;90.6321;157.407;346.073;397.209;847.87;712.184;98.0534;1187.86;37.7305;481.517;1955.3;1510.69;1071.05;76.7052;414.362;17.0564;150.565;58.2504;285.773;694.216;220.085;720.942;510.267;50.1592;2639.93;2662.07;2287.79;57.2115;1531.55 0 Exp 2,12(0.2);Exp 4,21(0.34);Exp 5,2(0.04);Hill,9(0.15);Linear,3(0.05);Poly 2,15(0.24);Power,1(0.02) 1.9828486420915354 140.4867752790451 1.5018656253814697 15.48720932006836 1.8941974384017157 1.7986326217651367 173.31423145898353 316.94121934328973 100.3065379933266 198.20266487243853 440.6963292487143 803.3194771091149 DOWN 0.15873015873015872 0.8412698412698413 0.0 GO:0050729 7 positive regulation of inflammatory response 47 52 4 4 3 2 2 2 66 50 2429 0.83995 0.40725 0.64856 3.85 688621;24232 tslp;c3 TSLP_32811;C3_8175 289.717 289.717 234.759 77.72234896090062 314.027773541571 69.7046347642744 186.67399999999998 186.67399999999998 129.148 81.35404938907467 212.12073311897106 72.96169473870326 627.3254999999999 627.3254999999999 560.435 94.59745229391834 597.7363628847037 84.83892921321277 344.675;234.759 244.2;129.148 560.435;694.216 0 2 0 2 688621;24232 TSLP_32811;C3_8175 289.717 289.717 77.72234896090062 186.67399999999998 186.67399999999998 81.35404938907467 627.3254999999999 627.3254999999999 94.59745229391834 344.675;234.759 244.2;129.148 560.435;694.216 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.6148148168080627 3.232623815536499 1.5467612743377686 1.6858625411987305 0.09835944906902575 1.6163119077682495 181.99931999999995 397.43468 73.92304 299.42495999999994 496.22011999999984 758.43088 DOWN 0.0 1.0 0.0 GO:0032286 8 central nervous system myelin maintenance 1 1 1 1 1 1 1 1 67 0 2479 1.0 0.026698 0.026698 100.0 24854 clu CLU_32773 935.649 935.649 935.649 935.649 808.484 808.484 808.484 808.484 1071.05 1071.05 1071.05 1071.05 0.0 935.649 0.0 935.649 935.649 808.484 1071.05 0 1 0 1 24854 CLU_32773 935.649 935.649 808.484 808.484 1071.05 1071.05 935.649 808.484 1071.05 0 Poly 2,1(1) 1.5548590421676636 1.5548590421676636 1.5548590421676636 1.5548590421676636 0.0 1.5548590421676636 935.649 935.649 808.484 808.484 1071.05 1071.05 DOWN 0.0 1.0 0.0 GO:0009411 6 response to UV 49 51 4 4 4 2 2 2 66 49 2430 0.8464 0.39774 0.39774 3.92 300795;246142 pclaf;bmf NS5ATP9_9367;BMF_8152 205.8085 205.8085 119.401 122.19865839075321 157.4871046323291 101.30447972297412 114.67179999999999 114.67179999999999 81.8286 46.447298871732016 96.3050002159594 38.50549186630301 439.28950000000003 439.28950000000003 220.085 310.00197683321306 316.7044545945363 256.99618465335374 292.216;119.401 147.515;81.8286 658.494;220.085 0 2 0 2 300795;246142 NS5ATP9_9367;BMF_8152 205.8085 205.8085 122.19865839075321 114.67179999999999 114.67179999999999 46.447298871732016 439.28950000000003 439.28950000000003 310.00197683321306 292.216;119.401 147.515;81.8286 658.494;220.085 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.634466588147425 3.2695356607437134 1.6033858060836792 1.6661498546600342 0.04438088436306248 1.6347678303718567 36.44980000000001 375.1672 50.29912800000001 179.04447199999998 9.64868000000007 868.9303199999999 DOWN 0.0 1.0 0.0 GO:1901617 5 organic hydroxy compound biosynthetic process 60 64 7 7 6 7 6 6 62 58 2421 0.99869 0.0064232 0.0064232 9.38 362282;25315;64191;312495;113902;81639 pck1;ephx1;dhcr7;cyp26b1;ces1d;alox15 PCK1_9439;EPHX1_8567;DHCR7_8466;CYP26B1_8418;CES1D_32914;ALOX15_8036 254.37644999999998 100.47005 11.0684 318.7496727613677 226.692246731436 302.724442738038 143.66657166666667 34.9337 4.18343 191.76828337552803 114.25004025642878 175.1507174326672 716.6878333333334 281.60675 17.0564 1028.348602942451 709.0112355858133 1041.818669027442 2.5 100.47005 529.244;39.2381;161.702;18.1872;11.0684;766.819 356.883;18.9587;50.9087;10.0176;4.18343;421.048 1021.06;81.6965;481.517;36.7271;17.0564;2662.07 3 3 3 362282;25315;312495 PCK1_9439;EPHX1_8567;CYP26B1_8418 195.55643333333333 39.2381 289.17352784901203 128.61976666666666 18.9587 197.73230283932702 379.8278666666667 81.6965 555.7783266271754 529.244;39.2381;18.1872 356.883;18.9587;10.0176 1021.06;81.6965;36.7271 3 64191;113902;81639 DHCR7_8466;CES1D_32914;ALOX15_8036 313.19646666666665 161.702 400.0033405148678 158.71337666666668 50.9087 228.38652250893577 1053.5478 481.517 1412.2459641145097 161.702;11.0684;766.819 50.9087;4.18343;421.048 481.517;17.0564;2662.07 0 Exp 2,1(0.17);Exp 4,3(0.5);Exp 5,1(0.17);Linear,1(0.17) 1.7649988151217681 10.672090888023376 1.5021449327468872 2.090334892272949 0.243951077145311 1.709883213043213 -0.676407621858516 509.42930762185847 -9.780013085701285 297.1131564190346 -106.16242260489526 1539.538089271562 CONFLICT 0.5 0.5 0.0 GO:1903046 3 meiotic cell cycle process 29 29 7 7 4 4 3 3 65 26 2453 0.99333 0.040526 0.040526 10.34 315852;360243;312495 ttk;top2a;cyp26b1 TTK_32727;TOP2A_10059;CYP26B1_8418 280.6421666666667 86.3883 18.1872 396.9887483844137 205.27186311663587 348.3731889872147 161.11046666666667 26.6888 10.0176 247.40330188939137 113.21584369785542 217.26283688674766 802.3633666666668 262.273 36.7271 1136.4018958971792 587.7940733971668 997.2788410556266 0.5 52.28775 1.5 411.86965 737.351;86.3883;18.1872 446.625;26.6888;10.0176 2108.09;262.273;36.7271 1 2 1 312495 CYP26B1_8418 18.1872 18.1872 10.0176 10.0176 36.7271 36.7271 18.1872 10.0176 36.7271 2 315852;360243 TTK_32727;TOP2A_10059 411.86965 411.86965 460.3001394695042 236.6569 236.6569 296.9397346857102 1185.1815000000001 1185.1815000000001 1305.1897175294093 737.351;86.3883 446.625;26.6888 2108.09;262.273 0 Exp 4,2(0.67);Linear,1(0.34) 1.836333878695718 5.5618239641189575 1.5111545324325562 2.090334892272949 0.3038948994964648 1.9603345394134521 -168.59289239352137 729.8772257268547 -118.85272470404837 441.07365803738173 -483.59643672085485 2088.3231700541883 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0031100 5 animal organ regeneration 72 80 8 8 5 6 4 4 64 76 2403 0.93988 0.16314 0.16314 5.0 116669;291234;24426;114494 vwf;mki67;gstp1;ccna2 VWF_32396;MKI67_9232;GSTP1_8762;CCNA2_8221 17.688650000000003 17.21975 14.384 3.716139865057095 18.15737041909907 3.477720048397307 6.3162225 5.859265 4.11644 2.368052458151702 5.617710253114925 2.115679843723209 63.556850000000004 67.2149 25.7196 29.1586766102876 71.9257188986669 26.906939059839633 3.0 21.9311 19.6764;21.9311;14.7631;14.384 4.11644;6.82654;9.42992;4.89199 94.078;76.1794;25.7196;58.2504 1 3 1 24426 GSTP1_8762 14.7631 14.7631 9.42992 9.42992 25.7196 25.7196 14.7631 9.42992 25.7196 3 116669;291234;114494 VWF_32396;MKI67_9232;CCNA2_8221 18.663833333333333 19.6764 3.8740996429278023 5.278323333333334 4.89199 1.3957437393136762 76.16926666666667 76.1794 17.91380214955314 19.6764;21.9311;14.384 4.11644;6.82654;4.89199 94.078;76.1794;58.2504 0 Exp 4,3(0.75);Hill,1(0.25) 2.1916207136489296 9.168315291404724 1.6267951726913452 3.5281898975372314 0.8461318173583268 2.0066651105880737 14.046832932244033 21.330467067755965 3.9955310910113284 8.63691390898867 34.98134692191816 92.13235307808186 DOWN 0.25 0.75 0.0 GO:0005996 4 monosaccharide metabolic process 56 69 3 3 3 3 3 3 65 66 2413 0.88973 0.27939 0.43002 4.35 286989;362282;25283 ugt2b7;pck1;gclc UGT2B7_33032;PCK1_9439;GCLC_8699 231.88553333333334 131.7 34.7126 262.04614519861445 125.1237086494307 153.01025406084685 137.19056666666665 39.9158 14.7729 190.67410758423213 54.54642616845944 107.46469049001284 507.7643333333333 397.209 105.024 467.91810140272764 333.57857438510405 295.4257509610408 34.7126;529.244;131.7 14.7729;356.883;39.9158 105.024;1021.06;397.209 2 1 2 286989;362282 UGT2B7_33032;PCK1_9439 281.9783 281.9783 349.6865064496771 185.82795 185.82795 241.9083716224079 563.0419999999999 563.0419999999999 647.7352674110002 34.7126;529.244 14.7729;356.883 105.024;1021.06 1 25283 GCLC_8699 131.7 131.7 39.9158 39.9158 397.209 397.209 131.7 39.9158 397.209 0 Exp 4,1(0.34);Hill,1(0.34);Linear,1(0.34) 2.662399468112255 9.516914010047913 1.611412525177002 5.930812358856201 2.395833043895599 1.9746891260147095 -64.64759510889334 528.4186617755599 -78.5774981221796 352.9586314555129 -21.734844601651048 1037.2635112683176 UP 0.6666666666666666 0.3333333333333333 0.0 GO:1901880 8 negative regulation of protein depolymerization 12 13 3 3 2 3 2 2 66 11 2468 0.9957 0.04532 0.04532 15.38 684352;306575 twf2;ckap2 TWF2_10109;CKAP2_8324 85.3188 85.3188 32.2386 75.06673873347638 61.97684753701211 67.41900158346479 53.0023 53.0023 15.2683 53.363934562586365 36.408820053835804 47.92726112091628 187.9351 187.9351 76.7052 157.3028331214031 139.02188870345447 141.27695080705482 0.0 32.2386 0.5 85.3188 138.399;32.2386 90.7363;15.2683 299.165;76.7052 0 2 0 2 684352;306575 TWF2_10109;CKAP2_8324 85.3188 85.3188 75.06673873347638 53.0023 53.0023 53.363934562586365 187.9351 187.9351 157.3028331214031 138.399;32.2386 90.7363;15.2683 299.165;76.7052 0 Exp 4,1(0.5);Poly 2,1(0.5) 1.9219252390401498 3.8528754711151123 1.7946586608886719 2.0582168102264404 0.18636375463371294 1.9264377355575562 -18.71839200000001 189.35599200000001 -20.956340000000004 126.96094 -30.075504000000024 405.94570400000003 DOWN 0.0 1.0 0.0 GO:0006974 5 cellular response to DNA damage stimulus 142 151 11 11 9 7 6 6 62 145 2334 0.89533 0.21277 0.29281 3.97 360243;299112;300795;313108;316273;293502 top2a;pole2;pclaf;mms22l;mcm3;kif22 TOP2A_10059;POLE2_9520;NS5ATP9_9367;MMS22L_33129;MCM3_9207;KIF22_8963 119.97333337859966 106.52065 2.71598E-7 111.12944646055276 79.34982464315252 84.39367771805642 63.22082337859967 56.1379 2.71598E-7 62.25527266237139 41.88038614493412 50.61519600492896 291.46668337859984 251.3795 2.71599E-7 247.24753605165986 195.11302182927724 183.61694030940896 86.3883;2.71598E-7;292.216;126.653;197.273;17.3097 26.6888;2.71598E-7;147.515;85.587;116.413;3.12114 262.273;2.71599E-7;658.494;240.486;496.915;90.6321 0 6 0 6 360243;299112;300795;313108;316273;293502 TOP2A_10059;POLE2_9520;NS5ATP9_9367;MMS22L_33129;MCM3_9207;KIF22_8963 119.97333337859966 106.52065 111.12944646055276 63.22082337859967 56.1379 62.25527266237139 291.46668337859984 251.3795 247.24753605165986 86.3883;2.71598E-7;292.216;126.653;197.273;17.3097 26.6888;2.71598E-7;147.515;85.587;116.413;3.12114 262.273;2.71599E-7;658.494;240.486;496.915;90.6321 0 Exp 2,1(0.17);Exp 4,1(0.17);Hill,2(0.34);Poly 2,2(0.34) 1.7019189015239544 10.250663876533508 1.540663719177246 1.9603345394134521 0.16602102770220817 1.6577442288398743 31.051256564676194 208.89541019252312 13.406230450521072 113.03541630667826 93.62745090619455 489.3059158510051 DOWN 0.0 1.0 0.0 GO:0000280 7 nuclear division 10 10 3 3 2 3 2 2 66 8 2471 0.99809 0.027525 0.027525 20.0 360243;312495 top2a;cyp26b1 TOP2A_10059;CYP26B1_8418 52.28775 52.28775 18.1872 48.22546029438184 54.90333369721344 48.0833907337112 18.3532 18.3532 10.0176 11.788318570517168 18.992558000574547 11.75359083064417 149.50005000000002 149.50005000000002 36.7271 159.48503535882298 158.14997176098822 159.01520119303868 0.0 18.1872 0.0 18.1872 86.3883;18.1872 26.6888;10.0176 262.273;36.7271 1 1 1 312495 CYP26B1_8418 18.1872 18.1872 10.0176 10.0176 36.7271 36.7271 18.1872 10.0176 36.7271 1 360243 TOP2A_10059 86.3883 86.3883 26.6888 26.6888 262.273 262.273 86.3883 26.6888 262.273 0 Exp 4,2(1) 2.0242914039890008 4.050669431686401 1.9603345394134521 2.090334892272949 0.09192413106359436 2.0253347158432007 -14.549327999999988 119.124828 2.015424000000003 34.690976 -71.53493199999997 370.535032 CONFLICT 0.5 0.5 0.0 GO:0046890 6 regulation of lipid biosynthetic process 73 78 6 5 4 4 3 3 65 75 2404 0.8471 0.34613 0.46335 3.85 64191;113902;24232 dhcr7;ces1d;c3 DHCR7_8466;CES1D_32914;C3_8175 135.84313333333333 161.702 11.0684 114.06525268920998 156.09601376415026 75.37572564064395 61.413376666666665 50.9087 4.18343 63.141088941549256 59.2861584616538 44.464144661650394 397.5964666666667 481.517 17.0564 346.2921785201816 461.94477776445007 228.8811526189388 161.702;11.0684;234.759 50.9087;4.18343;129.148 481.517;17.0564;694.216 0 3 0 3 64191;113902;24232 DHCR7_8466;CES1D_32914;C3_8175 135.84313333333333 161.702 114.06525268920998 61.413376666666665 50.9087 63.141088941549256 397.5964666666667 481.517 346.2921785201816 161.702;11.0684;234.759 50.9087;4.18343;129.148 481.517;17.0564;694.216 0 Exp 4,1(0.34);Exp 5,1(0.34);Poly 2,1(0.34) 1.6523850637601878 4.966527700424194 1.5467612743377686 1.7927976846694946 0.125476685353919 1.6269687414169312 6.766148816549077 264.92011785011755 -10.037491740099284 132.8642450734326 5.729976992364584 789.4629563409687 DOWN 0.0 1.0 0.0 GO:0050767 7 regulation of neurogenesis 202 215 14 12 9 8 8 8 60 207 2272 0.88531 0.21112 0.27484 3.72 684352;24832;25671;338475;361921;84032;29397;29657 twf2;thy1;smad1;nrep;ect2;col3a1;ccl11;arntl TWF2_10109;THY1_33010;SMAD1_32578;NREP_9364;ECT2_8523;COL3A1_8354;CCL11_33230;ARNTL_8086 181.7434875000007 42.2282 5.72311E-12 333.4110345279504 226.71469586889924 385.003591319753 101.11495125000073 18.5417 5.72311E-12 187.99666737490395 126.30442863762404 216.79255813906042 544.6923500000007 114.46705 5.72313E-12 845.7796965776537 614.9379486568386 920.8418168113774 138.399;5.72311E-12;21.9973;61.543;10.0162;212.603;986.476;22.9134 90.7363;5.72311E-12;5.02186;25.6719;3.29405;119.81;552.974;11.4115 299.165;5.72313E-12;80.1461;148.788;37.7305;1510.69;2230.86;50.1592 1 7 1 29397 CCL11_33230 986.476 986.476 552.974 552.974 2230.86 2230.86 986.476 552.974 2230.86 7 684352;24832;25671;338475;361921;84032;29657 TWF2_10109;THY1_33010;SMAD1_32578;NREP_9364;ECT2_8523;COL3A1_8354;ARNTL_8086 66.78170000000081 22.9134 79.61628899923605 36.56365857142939 11.4115 48.398593240430145 303.811257142858 80.1461 541.3064159700483 138.399;5.72311E-12;21.9973;61.543;10.0162;212.603;22.9134 90.7363;5.72311E-12;5.02186;25.6719;3.29405;119.81;11.4115 299.165;5.72313E-12;80.1461;148.788;37.7305;1510.69;50.1592 0 Exp 4,4(0.5);Hill,1(0.13);Poly 2,2(0.25);Power,1(0.13) 1.9165825549460167 15.810728907585144 1.6129854917526245 3.442979335784912 0.6048710047985835 1.7905151844024658 -49.2985718683924 412.7855468683938 -29.160092724440304 231.38999522444175 -41.403077663159365 1130.787777663161 DOWN 0.125 0.875 0.0 GO:0016477 4 cell migration 189 200 12 12 6 6 3 3 65 197 2282 0.20521 0.91319 0.36539 1.5 25682;245920;29397 ppard;cxcl10;ccl11 PPARD_9536;CXCL10_8408;CCL11_33230 583.7038 670.528 94.1074 452.4757019395849 597.2827229005389 505.7040574847414 321.8484 374.802 37.7692 261.6525545460621 328.86495635472806 292.09950093825955 1444.881666666667 1955.3 148.485 1131.1350787630683 1386.9098089171976 1209.8900456345082 94.1074;670.528;986.476 37.7692;374.802;552.974 148.485;1955.3;2230.86 1 2 1 29397 CCL11_33230 986.476 986.476 552.974 552.974 2230.86 2230.86 986.476 552.974 2230.86 2 25682;245920 PPARD_9536;CXCL10_8408 382.3177 382.3177 407.5909150756185 206.28560000000002 206.28560000000002 238.31817836228947 1051.8925 1051.8925 1277.611138849572 94.1074;670.528 37.7692;374.802 148.485;1955.3 0 Exp 2,1(0.34);Exp 5,1(0.34);Power,1(0.34) 1.923990342621337 5.7741827964782715 1.8538048267364502 1.9814788103103638 0.06500604870242216 1.9388991594314575 71.67934209949499 1095.728257900505 25.760661309408533 617.9361386905915 164.88182792784164 2724.8815054054917 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0051046 6 regulation of secretion 220 238 13 12 6 8 5 5 63 233 2246 0.37787 0.77683 0.83156 2.1 688621;25682;24367;113902;29657 tslp;ppard;fgg;ces1d;arntl TSLP_32811;PPARD_9536;FGG_8639;CES1D_32914;ARNTL_8086 103.04508000000001 42.4612 11.0684 138.7588760064451 144.03585056652963 154.4032712829768 63.641306 20.6424 4.18343 101.71394375685017 92.48790679434471 115.43220892443894 174.8378 98.0534 17.0564 221.1985749744785 243.9636187405996 242.93746507729753 344.675;94.1074;42.4612;11.0684;22.9134 244.2;37.7692;20.6424;4.18343;11.4115 560.435;148.485;98.0534;17.0564;50.1592 0 5 0 5 688621;25682;24367;113902;29657 TSLP_32811;PPARD_9536;FGG_8639;CES1D_32914;ARNTL_8086 103.04508000000001 42.4612 138.7588760064451 63.641306 20.6424 101.71394375685017 174.8378 98.0534 221.1985749744785 344.675;94.1074;42.4612;11.0684;22.9134 244.2;37.7692;20.6424;4.18343;11.4115 560.435;148.485;98.0534;17.0564;50.1592 0 Exp 2,1(0.2);Exp 4,2(0.4);Exp 5,2(0.4) 2.200468954976248 11.512347936630249 1.6269687414169312 3.442979335784912 0.7960606512005888 1.9388991594314575 -18.582437458895313 224.67259745889532 -25.514896659963654 152.79750865996365 -19.05129966625492 368.72689966625495 DOWN 0.0 1.0 0.0 GO:0031297 7 replication fork processing 3 3 1 1 1 1 1 1 67 2 2477 0.99793 0.078005 0.078005 33.33 313108 mms22l MMS22L_33129 126.653 126.653 126.653 126.653 85.587 85.587 85.587 85.587 240.486 240.486 240.486 240.486 0.0 126.653 0.0 126.653 126.653 85.587 240.486 0 1 0 1 313108 MMS22L_33129 126.653 126.653 85.587 85.587 240.486 240.486 126.653 85.587 240.486 0 Poly 2,1(1) 1.540663719177246 1.540663719177246 1.540663719177246 1.540663719177246 0.0 1.540663719177246 126.653 126.653 85.587 85.587 240.486 240.486 DOWN 0.0 1.0 0.0 GO:0006955 3 immune response 185 212 16 15 9 10 7 7 61 205 2274 0.79957 0.33579 0.50431 3.3 688621;295703;304545;245920;29397;24232;29221 tslp;serping1;oasl;cxcl10;ccl11;c3;arg1 TSLP_32811;SERPING1_32597;OASL_9389;CXCL10_8408;CCL11_33230;C3_8175;ARG1_33267 443.7681857142857 344.675 32.3997 366.07673441252007 505.27315681213514 365.0238101356277 250.98707142857145 244.2 13.7308 205.61963936959523 291.37379169280865 200.0123176801463 1205.802642857143 694.216 99.4885 1038.040491879239 1331.137561529603 1077.9069179175372 344.675;32.3997;76.6126;670.528;986.476;234.759;760.927 244.2;13.7308;28.4477;374.802;552.974;129.148;413.607 560.435;99.4885;260.389;1955.3;2230.86;694.216;2639.93 1 6 1 29397 CCL11_33230 986.476 986.476 552.974 552.974 2230.86 2230.86 986.476 552.974 2230.86 6 688621;295703;304545;245920;24232;29221 TSLP_32811;SERPING1_32597;OASL_9389;CXCL10_8408;C3_8175;ARG1_33267 353.31688333333335 289.717 303.46421619939593 200.65591666666668 186.67399999999998 171.62817991279192 1034.95975 627.3254999999999 1023.6505289417744 344.675;32.3997;76.6126;670.528;234.759;760.927 244.2;13.7308;28.4477;374.802;129.148;413.607 560.435;99.4885;260.389;1955.3;694.216;2639.93 0 Exp 2,3(0.43);Exp 4,2(0.29);Poly 2,1(0.15);Power,1(0.15) 1.7340962241483995 12.192593455314636 1.513624906539917 1.9814788103103638 0.17633278630728869 1.7183171510696411 172.5747457080784 714.961625720493 98.66191090460566 403.3122319525372 436.81148500540667 1974.7938007088792 DOWN 0.14285714285714285 0.8571428571428571 0.0 GO:0022408 7 negative regulation of cell-cell adhesion 60 62 3 2 2 2 2 2 66 60 2419 0.77146 0.49803 0.68099 3.23 24367;29221 fgg;arg1 FGG_8639;ARG1_33267 401.6941 401.6941 42.4612 508.0320392306179 355.60372956958275 503.8332148558626 217.12470000000002 217.12470000000002 20.6424 277.8679334262592 191.91558916961566 275.5713880083758 1368.9916999999998 1368.9916999999998 98.0534 1797.3781807994055 1205.9275234137106 1782.5230639299598 42.4612;760.927 20.6424;413.607 98.0534;2639.93 0 2 0 2 24367;29221 FGG_8639;ARG1_33267 401.6941 401.6941 508.0320392306179 217.12470000000002 217.12470000000002 277.8679334262592 1368.9916999999998 1368.9916999999998 1797.3781807994055 42.4612;760.927 20.6424;413.607 98.0534;2639.93 0 Exp 2,1(0.5);Exp 4,1(0.5) 2.0651506712039818 4.331263065338135 1.513624906539917 2.8176381587982178 0.9220766134289685 2.1656315326690674 -302.40238399999987 1105.7905839999999 -167.98060799999996 602.230008 -1122.0473679999996 3860.0307679999996 DOWN 0.0 1.0 0.0 GO:0042327 9 positive regulation of phosphorylation 290 309 21 20 14 13 10 10 58 299 2180 0.80544 0.30662 0.45535 3.24 688621;24832;363131;81687;24367;361921;24854;29397;24232;81639 tslp;thy1;pik3r4;mmp9;fgg;ect2;clu;ccl11;c3;alox15 TSLP_32811;THY1_33010;PIK3R4_9484;MMP9_32531;FGG_8639;ECT2_8523;CLU_32773;CCL11_33230;C3_8175;ALOX15_8036 500.4799400000005 536.4955 5.72311E-12 415.16644812356606 461.48021335878707 405.24024066697183 335.81554500000055 332.624 5.72311E-12 302.3367615938831 299.384846218717 280.27360457517176 1068.2444900000005 882.633 5.72313E-12 967.5460868213173 1059.3985478822722 1021.7155603048769 344.675;5.72311E-12;955.628;728.316;42.4612;10.0162;935.649;986.476;234.759;766.819 244.2;5.72311E-12;735.228;443.137;20.6424;3.29405;808.484;552.974;129.148;421.048 560.435;5.72313E-12;1288.97;2039.06;98.0534;37.7305;1071.05;2230.86;694.216;2662.07 1 9 1 29397 CCL11_33230 986.476 986.476 552.974 552.974 2230.86 2230.86 986.476 552.974 2230.86 9 688621;24832;363131;81687;24367;361921;24854;24232;81639 TSLP_32811;THY1_33010;PIK3R4_9484;MMP9_32531;FGG_8639;ECT2_8523;CLU_32773;C3_8175;ALOX15_8036 446.4803777777784 344.675 401.3777634614601 311.6868277777784 244.2 310.2962510184002 939.0649888888895 694.216 930.2854370736703 344.675;5.72311E-12;955.628;728.316;42.4612;10.0162;935.649;234.759;766.819 244.2;5.72311E-12;735.228;443.137;20.6424;3.29405;808.484;129.148;421.048 560.435;5.72313E-12;1288.97;2039.06;98.0534;37.7305;1071.05;694.216;2662.07 0 Exp 2,2(0.2);Exp 4,2(0.2);Hill,1(0.1);Linear,1(0.1);Poly 2,3(0.3);Power,1(0.1) 1.7799971577247162 18.14099633693695 1.5018656253814697 2.8176381587982178 0.40490147959855394 1.6608489751815796 243.15710950608963 757.8027704939116 148.42527874094665 523.2058112590546 468.55321239447665 1667.9357676055242 DOWN 0.1 0.9 0.0 GO:0034654 5 nucleobase-containing compound biosynthetic process 143 160 4 4 3 3 3 3 65 157 2322 0.37171 0.8122 0.79802 1.88 25682;299112;300795 ppard;pole2;pclaf PPARD_9536;POLE2_9520;NS5ATP9_9367 128.77446675719935 94.1074 2.71598E-7 149.16065755579936 69.06520680555445 123.45112246155901 61.76140009053265 37.7692 2.71598E-7 76.62824567420115 32.12207768675316 61.71326821226564 268.99300009053303 148.485 2.71599E-7 345.39140186742026 137.72422662717474 274.9272113412156 94.1074;2.71598E-7;292.216 37.7692;2.71598E-7;147.515 148.485;2.71599E-7;658.494 0 3 0 3 25682;299112;300795 PPARD_9536;POLE2_9520;NS5ATP9_9367 128.77446675719935 94.1074 149.16065755579936 61.76140009053265 37.7692 76.62824567420115 268.99300009053303 148.485 345.39140186742026 94.1074;2.71598E-7;292.216 37.7692;2.71598E-7;147.515 148.485;2.71599E-7;658.494 0 Exp 2,1(0.34);Exp 5,1(0.34);Hill,1(0.34) 1.746598308596861 5.254387617111206 1.6493386030197144 1.9388991594314575 0.16254236230620375 1.6661498546600342 -40.01670699579168 297.5656405101903 -24.95162291382381 148.47442309488912 -121.8541648435841 659.8401650246501 DOWN 0.0 1.0 0.0 GO:0070741 6 response to interleukin-6 14 14 3 3 2 3 2 2 66 12 2467 0.99463 0.051979 0.051979 14.29 362282;24367 pck1;fgg PCK1_9439;FGG_8639 285.8526 285.8526 42.4612 344.20741884497494 115.69881546660059 246.11811474542657 188.7627 188.7627 20.6424 237.75800837023343 71.23058792911141 170.0037523365063 559.5567 559.5567 98.0534 652.6642259399391 236.92191064568098 466.6735231597871 0.0 42.4612 0.5 285.8526 529.244;42.4612 356.883;20.6424 1021.06;98.0534 1 1 1 362282 PCK1_9439 529.244 529.244 356.883 356.883 1021.06 1021.06 529.244 356.883 1021.06 1 24367 FGG_8639 42.4612 42.4612 20.6424 20.6424 98.0534 98.0534 42.4612 20.6424 98.0534 0 Exp 4,1(0.5);Linear,1(0.5) 2.1308161395352987 4.42905068397522 1.611412525177002 2.8176381587982178 0.8529303251746017 2.21452534198761 -191.1945439999999 762.899744 -140.75308799999993 518.2784879999999 -344.9897679999998 1464.1031679999996 CONFLICT 0.5 0.5 0.0 GO:0001408 9 guanine nucleotide transport 1 1 1 1 1 1 1 1 67 0 2479 1.0 0.026698 0.026698 100.0 89776 slc22a7 SLC22A7_9847 49.1516 49.1516 49.1516 49.1516 13.5995 13.5995 13.5995 13.5995 161.307 161.307 161.307 161.307 0.0 49.1516 0.0 49.1516 49.1516 13.5995 161.307 0 1 0 1 89776 SLC22A7_9847 49.1516 49.1516 13.5995 13.5995 161.307 161.307 49.1516 13.5995 161.307 0 Hill,1(1) 1.8974558115005493 1.8974558115005493 1.8974558115005493 1.8974558115005493 0.0 1.8974558115005493 49.1516 49.1516 13.5995 13.5995 161.307 161.307 DOWN 0.0 1.0 0.0 GO:0042886 6 amide transport 189 201 11 11 8 9 7 7 61 194 2285 0.83663 0.28732 0.48925 3.48 170551;363131;24367;24854;29657;24646;170913 slc5a6;pik3r4;fgg;clu;arntl;abcb1b;abcb1a SLC5A6_9881;PIK3R4_9484;FGG_8639;CLU_32773;ARNTL_8086;ABCB1B_7939;ABCB1A_7938 329.21495714285714 120.077 20.7941 426.2250805602984 219.90789353603856 343.65613842419697 254.89459285714287 82.2177 8.25355 356.0716030241769 165.00024000601556 292.321995153747 616.8971571428572 221.286 50.1592 652.517370469665 524.3907406157716 644.9884118856053 120.077;955.628;42.4612;935.649;22.9134;20.7941;206.982 82.2177;735.228;20.6424;808.484;11.4115;8.25355;118.025 221.286;1288.97;98.0534;1071.05;50.1592;57.2115;1531.55 0 7 0 7 170551;363131;24367;24854;29657;24646;170913 SLC5A6_9881;PIK3R4_9484;FGG_8639;CLU_32773;ARNTL_8086;ABCB1B_7939;ABCB1A_7938 329.21495714285714 120.077 426.2250805602984 254.89459285714287 82.2177 356.0716030241769 616.8971571428572 221.286 652.517370469665 120.077;955.628;42.4612;935.649;22.9134;20.7941;206.982 82.2177;735.228;20.6424;808.484;11.4115;8.25355;118.025 221.286;1288.97;98.0534;1071.05;50.1592;57.2115;1531.55 0 Exp 4,2(0.29);Hill,1(0.15);Poly 2,4(0.58) 2.3550187993986618 18.913489818572998 1.5018656253814697 6.191005229949951 1.7106495160236497 1.8874764442443848 13.462998746571543 644.9669155391429 -8.886942092401313 518.676127806687 133.50552438734712 1100.288789898367 DOWN 0.0 1.0 0.0 GO:0006979 4 response to oxidative stress 170 179 14 14 9 9 7 7 61 172 2307 0.89932 0.19742 0.32893 3.91 24314;81687;24426;25283;361921;114494;29221 nqo1;mmp9;gstp1;gclc;ect2;ccna2;arg1 NQO1_33055;MMP9_32531;GSTP1_8762;GCLC_8699;ECT2_8523;CCNA2_8221;ARG1_33267 240.82680000000002 25.6813 10.0162 346.8911582439704 241.80529160782493 339.4466850167859 131.71645714285714 9.42992 3.29405 203.2131276050097 130.8230485331635 201.4401622352864 754.8600857142857 86.1211 25.7196 1103.7036042773386 750.1969494385922 1065.256155064223 25.6813;728.316;14.7631;131.7;10.0162;14.384;760.927 7.73944;443.137;9.42992;39.9158;3.29405;4.89199;413.607 86.1211;2039.06;25.7196;397.209;37.7305;58.2504;2639.93 2 5 2 24314;24426 NQO1_33055;GSTP1_8762 20.2222 20.2222 7.720333258350962 8.584679999999999 8.584679999999999 1.1953498714602508 55.92035 55.92035 42.710310243839245 25.6813;14.7631 7.73944;9.42992 86.1211;25.7196 5 81687;25283;361921;114494;29221 MMP9_32531;GCLC_8699;ECT2_8523;CCNA2_8221;ARG1_33267 329.06864 131.7 382.6471480836464 180.969168 39.9158 226.56125319995778 1034.4359799999997 397.209 1218.5338315285514 728.316;131.7;10.0162;14.384;760.927 443.137;39.9158;3.29405;4.89199;413.607 2039.06;397.209;37.7305;58.2504;2639.93 0 Exp 2,1(0.15);Exp 4,3(0.43);Hill,2(0.29);Linear,1(0.15) 1.993422607838939 14.503258228302002 1.513624906539917 3.5281898975372314 0.6880855789084066 1.9746891260147095 -16.153766281795782 497.8073662817958 -18.825934517360196 282.25884880307444 -62.77498653788962 1572.4951579664607 DOWN 0.2857142857142857 0.7142857142857143 0.0 GO:0006766 4 vitamin metabolic process 19 23 3 3 3 3 3 3 65 20 2459 0.99719 0.021998 0.021998 13.04 25682;25283;312495 ppard;gclc;cyp26b1 PPARD_9536;GCLC_8699;CYP26B1_8418 81.33153333333333 94.1074 18.1872 57.82478722635589 85.49763940015784 61.4453198550238 29.234199999999998 37.7692 10.0176 16.676638137226586 29.357504477769 16.962664969667912 194.14036666666667 148.485 36.7271 184.52671740429173 223.6157347961063 200.00586440385345 0.5 56.1473 1.5 112.90369999999999 94.1074;131.7;18.1872 37.7692;39.9158;10.0176 148.485;397.209;36.7271 1 2 1 312495 CYP26B1_8418 18.1872 18.1872 10.0176 10.0176 36.7271 36.7271 18.1872 10.0176 36.7271 2 25682;25283 PPARD_9536;GCLC_8699 112.90369999999999 112.90369999999999 26.581982382433427 38.8425 38.8425 1.5178754164949093 272.847 272.847 175.87442704384296 94.1074;131.7 37.7692;39.9158 148.485;397.209 0 Exp 4,1(0.34);Exp 5,1(0.34);Hill,1(0.34) 2.000276083612568 6.003923177719116 1.9388991594314575 2.090334892272949 0.07914927473106893 1.9746891260147095 15.896626650233287 146.76644001643336 10.36280742529674 48.105592574703266 -14.67127126678318 402.9520046001164 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0070670 6 response to interleukin-4 17 17 2 2 2 2 2 2 66 15 2464 0.99053 0.073823 0.073823 11.76 29397;29221 ccl11;arg1 CCL11_33230;ARG1_33267 873.7015 873.7015 760.927 159.48722738984432 868.5930922727721 159.32352005113623 483.29050000000007 483.29050000000007 413.607 98.54735077362508 480.13400868449617 98.44619581096251 2435.395 2435.395 2230.86 289.25617097998 2444.6599328925286 288.9592609469347 0.0 760.927 0.5 873.7015 986.476;760.927 552.974;413.607 2230.86;2639.93 1 1 1 29397 CCL11_33230 986.476 986.476 552.974 552.974 2230.86 2230.86 986.476 552.974 2230.86 1 29221 ARG1_33267 760.927 760.927 413.607 413.607 2639.93 2639.93 760.927 413.607 2639.93 0 Exp 2,1(0.5);Power,1(0.5) 1.7318243788175667 3.4951037168502808 1.513624906539917 1.9814788103103638 0.3308226679606814 1.7475518584251404 652.66348 1094.73952 346.7108400000001 619.87016 2034.5064000000002 2836.2835999999998 CONFLICT 0.5 0.5 0.0 GO:1904906 9 positive regulation of endothelial cell-matrix adhesion via fibronectin 2 2 1 1 1 1 1 1 67 1 2478 0.9993 0.052694 0.052694 50.0 81919 fut1 FUT1_8668 240.861 240.861 240.861 240.861 78.9726 78.9726 78.9726 78.9726 847.87 847.87 847.87 847.87 0.0 240.861 0.0 240.861 240.861 78.9726 847.87 0 1 0 1 81919 FUT1_8668 240.861 240.861 78.9726 78.9726 847.87 847.87 240.861 78.9726 847.87 0 Exp 2,1(1) 2.7370085716247554 2.737008571624756 2.737008571624756 2.737008571624756 0.0 2.737008571624756 240.861 240.861 78.9726 78.9726 847.87 847.87 DOWN 0.0 1.0 0.0 GO:0031333 7 negative regulation of protein-containing complex assembly 33 37 2 2 2 2 2 2 66 35 2444 0.92581 0.25957 0.25957 5.41 684352;24854 twf2;clu TWF2_10109;CLU_32773 537.024 537.024 138.399 563.740881300975 581.1390299102693 560.2780644662363 449.61015000000003 449.61015000000003 90.7363 507.5242658510478 489.3259998005983 504.4067634130987 685.1075 685.1075 299.165 545.8051177961781 727.8189830508476 542.4524726127571 0.5 537.024 138.399;935.649 90.7363;808.484 299.165;1071.05 0 2 0 2 684352;24854 TWF2_10109;CLU_32773 537.024 537.024 563.740881300975 449.61015000000003 449.61015000000003 507.5242658510478 685.1075 685.1075 545.8051177961781 138.399;935.649 90.7363;808.484 299.165;1071.05 0 Poly 2,2(1) 1.670461387308088 3.3495177030563354 1.5548590421676636 1.7946586608886719 0.16956393652357354 1.6747588515281677 -244.28099999999995 1318.329 -253.7825959999999 1153.002896 -71.33979999999985 1441.5548 DOWN 0.0 1.0 0.0 GO:0022407 6 regulation of cell-cell adhesion 137 143 9 8 6 6 5 5 63 138 2341 0.82063 0.33387 0.42998 3.5 24832;24367;309186;29221;81639 thy1;fgg;fermt3;arg1;alox15 THY1_33010;FGG_8639;FERMT3_32542;ARG1_33267;ALOX15_8036 421.8640400000011 539.113 5.72311E-12 377.3661077583767 416.85137070197646 386.0834173495915 237.90908000000113 334.248 5.72311E-12 210.65157915532305 232.4043357713333 214.50566520631702 1317.582680000001 1187.86 5.72313E-12 1303.4907312167236 1339.102691761245 1344.819801025813 5.72311E-12;42.4612;539.113;760.927;766.819 5.72311E-12;20.6424;334.248;413.607;421.048 5.72313E-12;98.0534;1187.86;2639.93;2662.07 0 5 0 5 24832;24367;309186;29221;81639 THY1_33010;FGG_8639;FERMT3_32542;ARG1_33267;ALOX15_8036 421.8640400000011 539.113 377.3661077583767 237.90908000000113 334.248 210.65157915532305 1317.582680000001 1187.86 1303.4907312167236 5.72311E-12;42.4612;539.113;760.927;766.819 5.72311E-12;20.6424;334.248;413.607;421.048 5.72313E-12;98.0534;1187.86;2639.93;2662.07 0 Exp 2,3(0.6);Exp 4,1(0.2);Hill,1(0.2) 1.8194406452941565 9.36698603630066 1.5021449327468872 2.8176381587982178 0.5477630974745048 1.6703740358352661 91.08806241392267 752.6400175860797 53.264829780880945 422.55333021912134 175.0226778477329 2460.142682152269 DOWN 0.0 1.0 0.0 GO:0035902 4 response to immobilization stress 19 21 2 2 2 2 2 2 66 19 2460 0.98284 0.10656 0.10656 9.52 116669;24296 vwf;cyp1a1 VWF_32396;CYP1A1_8415 16.28135 16.28135 12.8863 4.8013257549347825 17.86031127532777 4.250469572533223 6.623900000000001 6.623900000000001 4.11644 3.5460839391080414 5.45773683909416 3.139241670768945 56.7007 56.7007 19.3234 52.8594845848879 74.08404023837902 46.79491505381229 0.5 16.28135 19.6764;12.8863 4.11644;9.13136 94.078;19.3234 1 1 1 24296 CYP1A1_8415 12.8863 12.8863 9.13136 9.13136 19.3234 19.3234 12.8863 9.13136 19.3234 1 116669 VWF_32396 19.6764 19.6764 4.11644 4.11644 94.078 94.078 19.6764 4.11644 94.078 0 Exp 4,1(0.5);Hill,1(0.5) 5.6910652587573685 17.578497886657715 2.0912885665893555 15.48720932006836 9.47234640502261 8.789248943328857 9.627051999999999 22.935648 1.7092784000000005 11.538521600000001 -16.558808000000013 129.96020800000002 CONFLICT 0.5 0.5 0.0 GO:1901566 5 organonitrogen compound biosynthetic process 169 188 9 9 7 7 6 6 62 182 2297 0.76723 0.38732 0.63516 3.19 288583;24426;156275;25283;25612;29221 plod3;gstp1;ggt7;gclc;asns;arg1 PLOD3_9507;GSTP1_8762;GGT7_33026;GCLC_8699;ASNS_8091;ARG1_33267 348.4621833333333 161.4225 14.7631 372.9884380827396 288.465793316511 315.61249881736563 205.25455333333335 76.73989999999999 9.42992 255.0314903926216 154.75303259769487 201.74348209045095 837.5364333333333 453.738 25.7196 951.0291691066927 823.9202831207803 964.0735408824072 882.629;14.7631;109.609;131.7;191.145;760.927 625.677;9.42992;29.3336;39.9158;113.564;413.607 1106.02;25.7196;346.073;397.209;510.267;2639.93 1 5 1 24426 GSTP1_8762 14.7631 14.7631 9.42992 9.42992 25.7196 25.7196 14.7631 9.42992 25.7196 5 288583;156275;25283;25612;29221 PLOD3_9507;GGT7_33026;GCLC_8699;ASNS_8091;ARG1_33267 415.20199999999994 191.145 374.82521955439455 244.41948000000002 113.564 264.191484077008 999.8997999999999 510.267 965.8450338173819 882.629;109.609;131.7;191.145;760.927 625.677;29.3336;39.9158;113.564;413.607 1106.02;346.073;397.209;510.267;2639.93 0 Exp 2,1(0.17);Exp 4,2(0.34);Hill,1(0.17);Poly 2,2(0.34) 1.9951908691411655 12.468739867210388 1.513624906539917 3.5281898975372314 0.7292777512470122 1.8680835366249084 50.00927460160614 646.9150920650604 1.1868601975450588 409.32224646912164 76.55460969394528 1598.5182569727212 DOWN 0.16666666666666666 0.8333333333333334 0.0 GO:0009967 6 positive regulation of signal transduction 363 381 25 24 17 15 12 12 56 369 2110 0.7929 0.31296 0.4928 3.15 688621;25682;81687;24367;29243;84032;24854;29397;24232;246142;29657;81639 tslp;ppard;mmp9;fgg;f10;col3a1;clu;ccl11;c3;bmf;arntl;alox15 TSLP_32811;PPARD_9536;MMP9_32531;FGG_8639;F10_8585;COL3A1_8354;CLU_32773;CCL11_33230;C3_8175;BMF_8152;ARNTL_8086;ALOX15_8036 382.6975 223.68099999999998 22.9134 364.9346168929393 401.9202850173097 363.4390150536824 242.4063 124.479 11.4115 257.39446825194915 252.73069488382882 248.58041464427083 954.0173 627.3254999999999 50.1592 935.8460046771353 978.5382776294659 966.6816929786428 344.675;94.1074;728.316;42.4612;104.19;212.603;935.649;986.476;234.759;119.401;22.9134;766.819 244.2;37.7692;443.137;20.6424;38.4229;119.81;808.484;552.974;129.148;81.8286;11.4115;421.048 560.435;148.485;2039.06;98.0534;163.044;1510.69;1071.05;2230.86;694.216;220.085;50.1592;2662.07 1 11 1 29397 CCL11_33230 986.476 986.476 552.974 552.974 2230.86 2230.86 986.476 552.974 2230.86 11 688621;25682;81687;24367;29243;84032;24854;24232;246142;29657;81639 TSLP_32811;PPARD_9536;MMP9_32531;FGG_8639;F10_8585;COL3A1_8354;CLU_32773;C3_8175;BMF_8152;ARNTL_8086;ALOX15_8036 327.8085454545454 212.603 326.68957329098936 214.17287272727273 119.81 249.70990134538957 837.9406909090908 560.435 886.3039172693501 344.675;94.1074;728.316;42.4612;104.19;212.603;935.649;234.759;119.401;22.9134;766.819 244.2;37.7692;443.137;20.6424;38.4229;119.81;808.484;129.148;81.8286;11.4115;421.048 560.435;148.485;2039.06;98.0534;163.044;1510.69;1071.05;694.216;220.085;50.1592;2662.07 0 Exp 2,2(0.17);Exp 4,2(0.17);Exp 5,2(0.17);Linear,1(0.09);Poly 2,4(0.34);Power,1(0.09) 1.8704231262414612 23.260844349861145 1.5021449327468872 3.442979335784912 0.6028047395554976 1.6494240164756775 176.2163026862436 589.1786973137565 96.77166977748027 388.04093022251976 424.512576134028 1483.5220238659722 DOWN 0.08333333333333333 0.9166666666666666 0.0 GO:0090304 5 nucleic acid metabolic process 251 278 15 15 11 10 8 8 60 270 2209 0.67885 0.46811 0.8429 2.88 360243;25682;299112;300795;313108;291234;316273;293502 top2a;ppard;pole2;pclaf;mms22l;mki67;mcm3;kif22 TOP2A_10059;PPARD_9536;POLE2_9520;NS5ATP9_9367;MMS22L_33129;MKI67_9232;MCM3_9207;KIF22_8963 104.48481253394975 90.24785 2.71598E-7 100.07921231626834 74.65869995273047 76.79354314843388 52.99008503394975 32.229 2.71598E-7 56.52982922456502 37.913595470529835 45.95074098478624 246.6830625339499 194.4855 2.71599E-7 225.6433706464191 178.90723569195737 166.3499388633076 86.3883;94.1074;2.71598E-7;292.216;126.653;21.9311;197.273;17.3097 26.6888;37.7692;2.71598E-7;147.515;85.587;6.82654;116.413;3.12114 262.273;148.485;2.71599E-7;658.494;240.486;76.1794;496.915;90.6321 0 8 0 8 360243;25682;299112;300795;313108;291234;316273;293502 TOP2A_10059;PPARD_9536;POLE2_9520;NS5ATP9_9367;MMS22L_33129;MKI67_9232;MCM3_9207;KIF22_8963 104.48481253394975 90.24785 100.07921231626834 52.99008503394975 32.229 56.52982922456502 246.6830625339499 194.4855 225.6433706464191 86.3883;94.1074;2.71598E-7;292.216;126.653;21.9311;197.273;17.3097 26.6888;37.7692;2.71598E-7;147.515;85.587;6.82654;116.413;3.12114 262.273;148.485;2.71599E-7;658.494;240.486;76.1794;496.915;90.6321 0 Exp 2,1(0.13);Exp 4,2(0.25);Exp 5,1(0.13);Hill,2(0.25);Poly 2,2(0.25) 1.7563816795577083 14.111604690551758 1.540663719177246 1.9603345394134521 0.1739871086159483 1.763019621372223 35.13345664300101 173.83616842489852 13.816911961622509 92.163258106277 90.32018417035482 403.045940897545 DOWN 0.0 1.0 0.0 GO:0048518 4 positive regulation of biological process 1152 1238 79 77 52 53 39 39 29 1199 1280 0.94373 0.090098 0.17579 3.15 684352;688621;360243;24832;25671;295703;25682;363131;25154;362282;259241;24314;316351;81687;24426;25283;81919;24367;309186;29243;361921;312495;24296;245920;84032;24854;306575;113902;114494;29397;686019;24232;246142;25612;29657;29221;81639;252898;170913 twf2;tslp;top2a;thy1;smad1;serping1;ppard;pik3r4;pgr;pck1;nr1d2;nqo1;npas2;mmp9;gstp1;gclc;fut1;fgg;fermt3;f10;ect2;cyp26b1;cyp1a1;cxcl10;col3a1;clu;ckap2;ces1d;ccna2;ccl11;casq1;c3;bmf;asns;arntl;arg1;alox15;acox2;abcb1a TWF2_10109;TSLP_32811;TOP2A_10059;THY1_33010;SMAD1_32578;SERPING1_32597;PPARD_9536;PIK3R4_9484;PGR_32824;PCK1_9439;NR1D2_9358;NQO1_33055;NPAS2_9350;MMP9_32531;GSTP1_8762;GCLC_8699;FUT1_8668;FGG_8639;FERMT3_32542;F10_8585;ECT2_8523;CYP26B1_8418;CYP1A1_8415;CXCL10_8408;COL3A1_8354;CLU_32773;CKAP2_8324;CES1D_32914;CCNA2_8221;CCL11_33230;CASQ1_32992;C3_8175;BMF_8152;ASNS_8091;ARNTL_8086;ARG1_33267;ALOX15_8036;ACOX2_32902;ABCB1A_7938 268.2512564102566 131.7 5.72311E-12 314.996891505002 239.11492994383835 292.9291028191409 162.99462102564118 78.9726 5.72311E-12 214.55015610261947 140.2984730722804 193.9222582462999 723.3923923076925 285.773 5.72313E-12 834.7510121430153 665.4198241255714 815.8504825842522 138.399;344.675;86.3883;5.72311E-12;21.9973;32.3997;94.1074;955.628;283.618;529.244;29.1728;25.6813;21.0878;728.316;14.7631;131.7;240.861;42.4612;539.113;104.19;10.0162;18.1872;12.8863;670.528;212.603;935.649;32.2386;11.0684;14.384;986.476;147.66;234.759;119.401;191.145;22.9134;760.927;766.819;743.353;206.982 90.7363;244.2;26.6888;5.72311E-12;5.02186;13.7308;37.7692;735.228;138.711;356.883;3.35457;7.73944;11.3305;443.137;9.42992;39.9158;78.9726;20.6424;334.248;38.4229;3.29405;10.0176;9.13136;374.802;119.81;808.484;15.2683;4.18343;4.89199;552.974;96.6023;129.148;81.8286;113.564;11.4115;413.607;421.048;432.537;118.025 299.165;560.435;262.273;5.72313E-12;80.1461;99.4885;148.485;1288.97;1554.21;1021.06;114.038;86.1211;43.5624;2039.06;25.7196;397.209;847.87;98.0534;1187.86;163.044;37.7305;36.7271;19.3234;1955.3;1510.69;1071.05;76.7052;17.0564;58.2504;2230.86;285.773;694.216;220.085;510.267;50.1592;2639.93;2662.07;2287.79;1531.55 7 32 7 362282;259241;24314;24426;312495;24296;29397 PCK1_9439;NR1D2_9358;NQO1_33055;GSTP1_8762;CYP26B1_8418;CYP1A1_8415;CCL11_33230 230.91581428571428 25.6813 383.4502746171983 135.64712714285716 9.42992 225.3473349291568 504.8356 86.1211 842.4262838970759 529.244;29.1728;25.6813;14.7631;18.1872;12.8863;986.476 356.883;3.35457;7.73944;9.42992;10.0176;9.13136;552.974 1021.06;114.038;86.1211;25.7196;36.7271;19.3234;2230.86 32 684352;688621;360243;24832;25671;295703;25682;363131;25154;316351;81687;25283;81919;24367;309186;29243;361921;245920;84032;24854;306575;113902;114494;686019;24232;246142;25612;29657;29221;81639;252898;170913 TWF2_10109;TSLP_32811;TOP2A_10059;THY1_33010;SMAD1_32578;SERPING1_32597;PPARD_9536;PIK3R4_9484;PGR_32824;NPAS2_9350;MMP9_32531;GCLC_8699;FUT1_8668;FGG_8639;FERMT3_32542;F10_8585;ECT2_8523;CXCL10_8408;COL3A1_8354;CLU_32773;CKAP2_8324;CES1D_32914;CCNA2_8221;CASQ1_32992;C3_8175;BMF_8152;ASNS_8091;ARNTL_8086;ARG1_33267;ALOX15_8036;ACOX2_32902;ABCB1A_7938 276.4183843750002 143.02949999999998 304.6086274998863 168.9768853125002 86.28245 215.3869971453008 771.2016906250002 348.187 838.8384152750209 138.399;344.675;86.3883;5.72311E-12;21.9973;32.3997;94.1074;955.628;283.618;21.0878;728.316;131.7;240.861;42.4612;539.113;104.19;10.0162;670.528;212.603;935.649;32.2386;11.0684;14.384;147.66;234.759;119.401;191.145;22.9134;760.927;766.819;743.353;206.982 90.7363;244.2;26.6888;5.72311E-12;5.02186;13.7308;37.7692;735.228;138.711;11.3305;443.137;39.9158;78.9726;20.6424;334.248;38.4229;3.29405;374.802;119.81;808.484;15.2683;4.18343;4.89199;96.6023;129.148;81.8286;113.564;11.4115;413.607;421.048;432.537;118.025 299.165;560.435;262.273;5.72313E-12;80.1461;99.4885;148.485;1288.97;1554.21;43.5624;2039.06;397.209;847.87;98.0534;1187.86;163.044;37.7305;1955.3;1510.69;1071.05;76.7052;17.0564;58.2504;285.773;694.216;220.085;510.267;50.1592;2639.93;2662.07;2287.79;1531.55 0 Exp 2,7(0.18);Exp 4,13(0.34);Exp 5,3(0.08);Hill,3(0.08);Linear,2(0.06);Poly 2,10(0.26);Power,1(0.03) 2.0042564715044295 89.7390022277832 1.5018656253814697 15.48720932006836 2.2274852958506064 1.805381178855896 169.38910985582345 367.1134029646897 95.65780105084197 230.33144100044035 461.40480092337026 985.3799836920148 DOWN 0.1794871794871795 0.8205128205128205 0.0 GO:0034330 5 cell junction organization 75 80 5 5 4 3 3 3 65 77 2402 0.83686 0.36098 0.47182 3.75 24832;361921;24232 thy1;ect2;c3 THY1_33010;ECT2_8523;C3_8175 81.59173333333523 10.0162 5.72311E-12 132.74125112116755 51.8622453891448 111.59626497755235 44.1473500000019 3.29405 5.72311E-12 73.63114535756759 27.366374869197127 62.05886493259327 243.98216666666858 37.7305 5.72313E-12 390.3700502934132 157.62656164159736 327.63743395927617 5.72311E-12;10.0162;234.759 5.72311E-12;3.29405;129.148 5.72313E-12;37.7305;694.216 0 3 0 3 24832;361921;24232 THY1_33010;ECT2_8523;C3_8175 81.59173333333523 10.0162 132.74125112116755 44.1473500000019 3.29405 73.63114535756759 243.98216666666858 37.7305 390.3700502934132 5.72311E-12;10.0162;234.759 5.72311E-12;3.29405;129.148 5.72313E-12;37.7305;694.216 0 Exp 4,1(0.34);Hill,1(0.34);Poly 2,1(0.34) 1.676773626490976 5.045800685882568 1.5467612743377686 1.863204002380371 0.16318020652393234 1.6358354091644287 -68.61913291871743 231.8025995853879 -39.17413472214504 127.46883472214886 -197.76313042945233 685.7274637627895 DOWN 0.0 1.0 0.0 GO:0010629 7 negative regulation of gene expression 355 375 22 19 13 9 7 7 61 368 2111 0.19423 0.89313 0.38527 1.87 25682;25154;259241;24426;25283;29657;29221 ppard;pgr;nr1d2;gstp1;gclc;arntl;arg1 PPARD_9536;PGR_32824;NR1D2_9358;GSTP1_8762;GCLC_8699;ARNTL_8086;ARG1_33267 191.0288142857143 94.1074 14.7631 268.26607813168397 221.21699253998895 285.63864621248007 93.45699857142858 37.7692 3.35457 148.56098653289456 105.9528528564534 161.2073003673684 704.2501142857143 148.485 25.7196 1009.0446354695042 770.3778481315499 1041.5328393825698 94.1074;283.618;29.1728;14.7631;131.7;22.9134;760.927 37.7692;138.711;3.35457;9.42992;39.9158;11.4115;413.607 148.485;1554.21;114.038;25.7196;397.209;50.1592;2639.93 2 5 2 259241;24426 NR1D2_9358;GSTP1_8762 21.96795 21.96795 10.18919658486379 6.392244999999999 6.392244999999999 4.295921183081692 69.8788 69.8788 62.45053954354597 29.1728;14.7631 3.35457;9.42992 114.038;25.7196 5 25682;25154;25283;29657;29221 PPARD_9536;PGR_32824;GCLC_8699;ARNTL_8086;ARG1_33267 258.65316 131.7 296.50796785136816 128.2829 39.9158 166.7175648353226 957.99864 397.209 1115.6086778124072 94.1074;283.618;131.7;22.9134;760.927 37.7692;138.711;39.9158;11.4115;413.607 148.485;1554.21;397.209;50.1592;2639.93 0 Exp 2,1(0.15);Exp 4,3(0.43);Exp 5,1(0.15);Hill,1(0.15);Poly 2,1(0.15) 2.1835732219208825 16.12134540081024 1.513624906539917 3.5281898975372314 0.8426088969635236 1.9746891260147095 -7.705477534982123 389.76310610641076 -16.59852039845876 203.51251754131593 -43.26061253480282 1451.7608411062315 DOWN 0.2857142857142857 0.7142857142857143 0.0 GO:0043085 5 positive regulation of catalytic activity 340 363 20 18 9 10 5 5 63 358 2121 0.062244 0.97476 0.11345 1.38 24832;363131;361921;24854;29397 thy1;pik3r4;ect2;clu;ccl11 THY1_33010;PIK3R4_9484;ECT2_8523;CLU_32773;CCL11_33230 577.5538400000012 935.649 5.72311E-12 522.9858884161467 502.2829259390199 534.2830485444648 419.9960100000011 552.974 5.72311E-12 393.06947337646227 353.0932421760701 389.8261120639548 925.7221000000012 1071.05 5.72313E-12 935.6741769291526 862.3839354838718 1004.5665657560565 5.72311E-12;955.628;10.0162;935.649;986.476 5.72311E-12;735.228;3.29405;808.484;552.974 5.72313E-12;1288.97;37.7305;1071.05;2230.86 1 4 1 29397 CCL11_33230 986.476 986.476 552.974 552.974 2230.86 2230.86 986.476 552.974 2230.86 4 24832;363131;361921;24854 THY1_33010;PIK3R4_9484;ECT2_8523;CLU_32773 475.32330000000144 472.8326 543.1498540169415 386.75151250000147 369.26102499999996 445.686927233773 599.4376250000014 554.3902499999999 676.4400660732825 5.72311E-12;955.628;10.0162;935.649 5.72311E-12;735.228;3.29405;808.484 5.72313E-12;1288.97;37.7305;1071.05 0 Exp 4,1(0.2);Hill,1(0.2);Poly 2,2(0.4);Power,1(0.2) 1.6977053188287619 8.537242889404297 1.5018656253814697 1.9814788103103638 0.2061726723207602 1.6358354091644287 119.13649687352455 1035.9711831264779 75.45542555887442 764.536594441128 105.56752275333872 1745.8766772466633 DOWN 0.2 0.8 0.0 GO:0045666 8 positive regulation of neuron differentiation 97 102 8 6 4 3 3 3 65 99 2380 0.71125 0.51794 0.75205 2.94 684352;25671;361921 twf2;smad1;ect2 TWF2_10109;SMAD1_32578;ECT2_8523 56.80416666666667 21.9973 10.0162 70.91667158943189 48.745371037638925 70.58513841263509 33.017403333333334 5.02186 3.29405 49.99349563855315 28.977601010553844 48.53111128905172 139.01386666666667 80.1461 37.7305 140.30702018004422 118.54430014943496 142.7906826303695 138.399;21.9973;10.0162 90.7363;5.02186;3.29405 299.165;80.1461;37.7305 0 3 0 3 684352;25671;361921 TWF2_10109;SMAD1_32578;ECT2_8523 56.80416666666667 21.9973 70.91667158943189 33.017403333333334 5.02186 49.99349563855315 139.01386666666667 80.1461 140.30702018004422 138.399;21.9973;10.0162 90.7363;5.02186;3.29405 299.165;80.1461;37.7305 0 Exp 4,2(0.67);Poly 2,1(0.34) 1.7066503946651943 5.123709559440613 1.6358354091644287 1.7946586608886719 0.0804238935670276 1.6932154893875122 -23.44560182042727 137.0539351537606 -23.5555626693788 89.59036933604547 -19.758473238813195 297.7862065721465 DOWN 0.0 1.0 0.0 GO:0051129 6 negative regulation of cellular component organization 177 187 15 13 9 10 8 8 60 179 2300 0.94234 0.12159 0.15569 4.28 684352;315852;360243;24832;25283;245920;24854;306575 twf2;ttk;top2a;thy1;gclc;cxcl10;clu;ckap2 TWF2_10109;TTK_32727;TOP2A_10059;THY1_33010;GCLC_8699;CXCL10_8408;CLU_32773;CKAP2_8324 341.5317375000007 135.0495 5.72311E-12 374.2770868784812 250.0365754035093 337.2327311465197 225.31502500000073 65.32605 5.72311E-12 292.33876738582694 160.20642389724364 270.55302790001326 771.2240250000008 348.187 5.72313E-12 843.2965219765673 556.1603488370934 702.9380796557276 138.399;737.351;86.3883;5.72311E-12;131.7;670.528;935.649;32.2386 90.7363;446.625;26.6888;5.72311E-12;39.9158;374.802;808.484;15.2683 299.165;2108.09;262.273;5.72313E-12;397.209;1955.3;1071.05;76.7052 0 8 0 8 684352;315852;360243;24832;25283;245920;24854;306575 TWF2_10109;TTK_32727;TOP2A_10059;THY1_33010;GCLC_8699;CXCL10_8408;CLU_32773;CKAP2_8324 341.5317375000007 135.0495 374.2770868784812 225.31502500000073 65.32605 292.33876738582694 771.2240250000008 348.187 843.2965219765673 138.399;737.351;86.3883;5.72311E-12;131.7;670.528;935.649;32.2386 90.7363;446.625;26.6888;5.72311E-12;39.9158;374.802;808.484;15.2683 299.165;2108.09;262.273;5.72313E-12;397.209;1955.3;1071.05;76.7052 0 Exp 2,1(0.13);Exp 4,2(0.25);Hill,2(0.25);Linear,1(0.13);Poly 2,2(0.25) 1.8116666018536505 14.570921540260315 1.5111545324325562 2.0582168102264404 0.19628391728250424 1.8585044145584106 82.17094864897052 600.8925263510309 22.734594674210484 427.895455325791 186.8493495441527 1355.5987004558488 DOWN 0.0 1.0 0.0 GO:0034116 8 positive regulation of heterotypic cell-cell adhesion 8 9 3 3 3 3 3 3 65 6 2473 0.99995 0.0013631 0.0013631 33.33 24832;24367;81639 thy1;fgg;alox15 THY1_33010;FGG_8639;ALOX15_8036 269.7600666666686 42.4612 5.72311E-12 430.98889287452846 271.23062087515706 425.3001742830788 147.23013333333526 20.6424 5.72311E-12 237.35773686326823 147.72657797021714 234.49881912229483 920.0411333333353 98.0534 5.72313E-12 1509.4376590432107 919.4024074657234 1494.565044437789 0.0 5.72311E-12 0.0 5.72311E-12 5.72311E-12;42.4612;766.819 5.72311E-12;20.6424;421.048 5.72313E-12;98.0534;2662.07 0 3 0 3 24832;24367;81639 THY1_33010;FGG_8639;ALOX15_8036 269.7600666666686 42.4612 430.98889287452846 147.23013333333526 20.6424 237.35773686326823 920.0411333333353 98.0534 1509.4376590432107 5.72311E-12;42.4612;766.819 5.72311E-12;20.6424;421.048 5.72313E-12;98.0534;2662.07 0 Exp 2,1(0.34);Exp 4,1(0.34);Hill,1(0.34) 1.9904555731169997 6.182987093925476 1.5021449327468872 2.8176381587982178 0.6796850543313646 1.863204002380371 -217.94977783827312 757.4699111716103 -121.36543108027143 415.8256977469419 -788.0483746628352 2628.1306413295056 DOWN 0.0 1.0 0.0 GO:0006749 5 glutathione metabolic process 22 29 5 5 3 3 3 3 65 26 2453 0.99333 0.040526 0.040526 10.34 24426;156275;25283 gstp1;ggt7;gclc GSTP1_8762;GGT7_33026;GCLC_8699 85.35736666666666 109.609 14.7631 62.126209725874425 102.47093588455094 55.61673965942662 26.226439999999997 29.3336 9.42992 15.478632119564056 31.14135085427135 14.49631364897953 256.33386666666667 346.073 25.7196 201.3477777792775 308.91087133101405 177.83922510860415 0.5 62.186049999999994 1.5 120.65449999999998 14.7631;109.609;131.7 9.42992;29.3336;39.9158 25.7196;346.073;397.209 1 2 1 24426 GSTP1_8762 14.7631 14.7631 9.42992 9.42992 25.7196 25.7196 14.7631 9.42992 25.7196 2 156275;25283 GGT7_33026;GCLC_8699 120.65449999999998 120.65449999999998 15.620695903192185 34.6247 34.6247 7.482745379872284 371.64099999999996 371.64099999999996 36.15861236275655 109.609;131.7 29.3336;39.9158 346.073;397.209 0 Exp 4,2(0.67);Hill,1(0.34) 2.3782724300402722 7.433664917945862 1.930785894393921 3.5281898975372314 0.9098527069555539 1.9746891260147095 15.05494220509577 155.65979112823754 8.710718855001712 43.74216114499829 28.487407011532923 484.1803263218004 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0006575 4 cellular modified amino acid metabolic process 61 71 8 8 5 4 4 4 64 67 2412 0.96092 0.11922 0.11922 5.63 288583;24426;156275;25283 plod3;gstp1;ggt7;gclc PLOD3_9507;GSTP1_8762;GGT7_33026;GCLC_8699 284.675275 120.65449999999998 14.7631 401.85025190084076 181.67892641815234 276.5830281559554 176.08908 34.6247 9.42992 299.99161461493156 91.50344442926603 207.74890590354187 468.7554 371.64099999999996 25.7196 455.5424419003202 389.83987177587403 320.2157522221273 2.5 507.1645 882.629;14.7631;109.609;131.7 625.677;9.42992;29.3336;39.9158 1106.02;25.7196;346.073;397.209 1 3 1 24426 GSTP1_8762 14.7631 14.7631 9.42992 9.42992 25.7196 25.7196 14.7631 9.42992 25.7196 3 288583;156275;25283 PLOD3_9507;GGT7_33026;GCLC_8699 374.646 131.7 440.0648239600615 231.64213333333336 39.9158 341.2852221397424 616.434 397.209 424.7641241571609 882.629;109.609;131.7 625.677;29.3336;39.9158 1106.02;346.073;397.209 0 Exp 4,2(0.5);Hill,1(0.25);Poly 2,1(0.25) 2.1919461418633768 9.149733781814575 1.7160688638687134 3.5281898975372314 0.8348533890240838 1.9527375102043152 -109.13797186282392 678.488521862824 -117.90270232263288 470.0808623226329 22.32380693768613 915.1869930623138 DOWN 0.25 0.75 0.0 GO:0043549 7 regulation of kinase activity 234 250 16 15 9 8 6 6 62 244 2235 0.49256 0.67103 1.0 2.4 24832;363131;24426;361921;24854;114494 thy1;pik3r4;gstp1;ect2;clu;ccna2 THY1_33010;PIK3R4_9484;GSTP1_8762;ECT2_8523;CLU_32773;CCNA2_8221 321.74005000000096 14.573550000000001 5.72311E-12 483.3402817438313 228.86944629500758 432.50171954665853 260.2213266666676 7.1609549999999995 5.72311E-12 396.9986052493902 187.3834397292434 362.913756551943 413.6200833333343 47.990449999999996 5.72313E-12 597.9265040010391 294.4152383893835 516.2816729564752 5.72311E-12;955.628;14.7631;10.0162;935.649;14.384 5.72311E-12;735.228;9.42992;3.29405;808.484;4.89199 5.72313E-12;1288.97;25.7196;37.7305;1071.05;58.2504 1 5 1 24426 GSTP1_8762 14.7631 14.7631 9.42992 9.42992 25.7196 25.7196 14.7631 9.42992 25.7196 5 24832;363131;361921;24854;114494 THY1_33010;PIK3R4_9484;ECT2_8523;CLU_32773;CCNA2_8221 383.13544000000115 14.384 513.5677468415115 310.37960800000116 4.89199 422.06749082948534 491.20018000000107 58.2504 633.8415375648401 5.72311E-12;955.628;10.0162;935.649;14.384 5.72311E-12;735.228;3.29405;808.484;4.89199 5.72313E-12;1288.97;37.7305;1071.05;58.2504 0 Exp 4,3(0.5);Hill,1(0.17);Poly 2,2(0.34) 1.8558141860105963 11.71074914932251 1.5018656253814697 3.5281898975372314 0.7820894047773227 1.631315290927887 -65.01272371911153 708.4928237191134 -57.443717076151415 577.8863704094866 -64.82076390632415 892.0609305729928 DOWN 0.16666666666666666 0.8333333333333334 0.0 GO:0050878 4 regulation of body fluid levels 107 110 11 11 9 10 8 8 60 102 2377 0.99782 0.0079617 0.0079617 7.27 116669;295703;24367;29243;312495;24232;24646;170913 vwf;serping1;fgg;f10;cyp26b1;c3;abcb1b;abcb1a VWF_32396;SERPING1_32597;FGG_8639;F10_8585;CYP26B1_8418;C3_8175;ABCB1B_7939;ABCB1A_7938 84.9312 37.43045 18.1872 88.7254563717442 67.4357048913703 78.53920967757728 42.794586249999995 17.1866 4.11644 51.038465741853656 33.180136824048226 45.26774044492609 346.79606249999995 98.77095 36.7271 524.4057409436267 304.82466650078885 528.8713724238145 4.5 73.3256 19.6764;32.3997;42.4612;104.19;18.1872;234.759;20.7941;206.982 4.11644;13.7308;20.6424;38.4229;10.0176;129.148;8.25355;118.025 94.078;99.4885;98.0534;163.044;36.7271;694.216;57.2115;1531.55 1 7 1 312495 CYP26B1_8418 18.1872 18.1872 10.0176 10.0176 36.7271 36.7271 18.1872 10.0176 36.7271 7 116669;295703;24367;29243;24232;24646;170913 VWF_32396;SERPING1_32597;FGG_8639;F10_8585;C3_8175;ABCB1B_7939;ABCB1A_7938 94.46605714285714 42.4612 91.30013710967904 47.47701285714286 20.6424 53.2395032484103 391.09162857142854 99.4885 550.0200339111134 19.6764;32.3997;42.4612;104.19;234.759;20.7941;206.982 4.11644;13.7308;20.6424;38.4229;129.148;8.25355;118.025 94.078;99.4885;98.0534;163.044;694.216;57.2115;1531.55 0 Exp 4,3(0.38);Exp 5,1(0.13);Hill,2(0.25);Poly 2,2(0.25) 2.216436667400497 19.86532497406006 1.5225032567977905 6.191005229949951 1.5541370645173478 1.988905668258667 23.447595572955144 146.41480442704486 7.426733927126428 78.16243857287358 -16.598575904106553 710.1907009041065 DOWN 0.125 0.875 0.0 GO:0031401 8 positive regulation of protein modification process 319 340 23 22 14 13 10 10 58 330 2149 0.707 0.4232 0.71768 2.94 688621;24832;81687;24367;361921;24854;29397;24232;29657;81639 tslp;thy1;mmp9;fgg;ect2;clu;ccl11;c3;arntl;alox15 TSLP_32811;THY1_33010;MMP9_32531;FGG_8639;ECT2_8523;CLU_32773;CCL11_33230;C3_8175;ARNTL_8086;ALOX15_8036 407.2084800000006 289.717 5.72311E-12 406.22694914820585 431.196699351492 400.36439661747454 263.4338950000006 186.67399999999998 5.72311E-12 282.052851496488 275.17345903553013 270.36614969279054 944.3634100000006 627.3254999999999 5.72313E-12 1014.3208761552485 1024.9656711062921 1040.7128690547263 344.675;5.72311E-12;728.316;42.4612;10.0162;935.649;986.476;234.759;22.9134;766.819 244.2;5.72311E-12;443.137;20.6424;3.29405;808.484;552.974;129.148;11.4115;421.048 560.435;5.72313E-12;2039.06;98.0534;37.7305;1071.05;2230.86;694.216;50.1592;2662.07 1 9 1 29397 CCL11_33230 986.476 986.476 552.974 552.974 2230.86 2230.86 986.476 552.974 2230.86 9 688621;24832;81687;24367;361921;24854;24232;29657;81639 TSLP_32811;THY1_33010;MMP9_32531;FGG_8639;ECT2_8523;CLU_32773;C3_8175;ARNTL_8086;ALOX15_8036 342.84542222222285 234.759 372.88549169665197 231.26277222222285 129.148 279.024191752535 801.4193444444451 560.435 963.1102629800217 344.675;5.72311E-12;728.316;42.4612;10.0162;935.649;234.759;22.9134;766.819 244.2;5.72311E-12;443.137;20.6424;3.29405;808.484;129.148;11.4115;421.048 560.435;5.72313E-12;2039.06;98.0534;37.7305;1071.05;694.216;50.1592;2662.07 0 Exp 2,2(0.2);Exp 4,3(0.3);Hill,1(0.1);Linear,1(0.1);Poly 2,2(0.2);Power,1(0.1) 1.9339695981196223 20.082110047340393 1.5021449327468872 3.442979335784912 0.6372225878238498 1.7745332717895508 155.42640837505397 658.9905516249472 88.61572647027049 438.2520635297308 315.68081760600137 1573.046002394 DOWN 0.1 0.9 0.0 GO:0044237 3 cellular metabolic process 1201 1328 78 78 55 52 41 41 27 1287 1192 0.9321 0.10692 0.17834 3.09 286989;684352;315852;360243;24832;25671;291463;25682;299112;288583;363131;25154;362282;300795;24314;313108;291234;316273;293502;362376;24426;156275;25283;81919;84493;25315;312495;24296;84032;113902;297594;114494;29397;24232;116599;25612;29657;29221;81639;26760;252898 ugt2b7;twf2;ttk;top2a;thy1;smad1;ppic;ppard;pole2;plod3;pik3r4;pgr;pck1;pclaf;nqo1;mms22l;mki67;mcm3;kif22;herc6;gstp1;ggt7;gclc;fut1;fmo3;ephx1;cyp26b1;cyp1a1;col3a1;ces1d;cdca3;ccna2;ccl11;c3;blvra;asns;arntl;arg1;alox15;akr7a3;acox2 UGT2B7_33032;TWF2_10109;TTK_32727;TOP2A_10059;THY1_33010;SMAD1_32578;PPIC_9541;PPARD_9536;POLE2_9520;PLOD3_9507;PIK3R4_9484;PGR_32824;PCK1_9439;NS5ATP9_9367;NQO1_33055;MMS22L_33129;MKI67_9232;MCM3_9207;KIF22_8963;HERC6_8794;GSTP1_8762;GGT7_33026;GCLC_8699;FUT1_8668;FMO3_8654;EPHX1_8567;CYP26B1_8418;CYP1A1_8415;COL3A1_8354;CES1D_32914;CDCA3_8260;CCNA2_8221;CCL11_33230;C3_8175;BLVRA_8151;ASNS_8091;ARNTL_8086;ARG1_33267;ALOX15_8036;AKR7A3_8015;ACOX2_32902 257.77251707979525 126.653 5.72311E-12 305.03353291444665 218.32518076756142 279.17409916823937 152.81302878711227 39.9158 5.72311E-12 199.38034301583696 123.61810638504124 174.01618184934787 670.8786170797953 299.165 5.72313E-12 790.4929007199953 591.8351415591666 774.1409082539151 34.7126;138.399;737.351;86.3883;5.72311E-12;21.9973;628.678;94.1074;2.71598E-7;882.629;955.628;283.618;529.244;292.216;25.6813;126.653;21.9311;197.273;17.3097;39.6865;14.7631;109.609;131.7;240.861;418.073;39.2381;18.1872;12.8863;212.603;11.0684;56.6562;14.384;986.476;234.759;415.991;191.145;22.9134;760.927;766.819;52.7573;743.353 14.7729;90.7363;446.625;26.6888;5.72311E-12;5.02186;389.239;37.7692;2.71598E-7;625.677;735.228;138.711;356.883;147.515;7.73944;85.587;6.82654;116.413;3.12114;15.7729;9.42992;29.3336;39.9158;78.9726;293.29;18.9587;10.0176;9.13136;119.81;4.18343;22.3266;4.89199;552.974;129.148;288.048;113.564;11.4115;413.607;421.048;12.408;432.537 105.024;299.165;2108.09;262.273;5.72313E-12;80.1461;1509.86;148.485;2.71599E-7;1106.02;1288.97;1554.21;1021.06;658.494;86.1211;240.486;76.1794;496.915;90.6321;157.407;25.7196;346.073;397.209;847.87;712.184;81.6965;36.7271;19.3234;1510.69;17.0564;150.565;58.2504;2230.86;694.216;720.942;510.267;50.1592;2639.93;2662.07;216.887;2287.79 9 32 9 286989;362282;24314;24426;25315;312495;24296;29397;26760 UGT2B7_33032;PCK1_9439;NQO1_33055;GSTP1_8762;EPHX1_8567;CYP26B1_8418;CYP1A1_8415;CCL11_33230;AKR7A3_8015 190.43843333333336 34.7126 341.6385467775848 110.25721333333334 12.408 201.49442555835756 424.8243 86.1211 747.4593329384365 34.7126;529.244;25.6813;14.7631;39.2381;18.1872;12.8863;986.476;52.7573 14.7729;356.883;7.73944;9.42992;18.9587;10.0176;9.13136;552.974;12.408 105.024;1021.06;86.1211;25.7196;81.6965;36.7271;19.3234;2230.86;216.887 32 684352;315852;360243;24832;25671;291463;25682;299112;288583;363131;25154;300795;313108;291234;316273;293502;362376;156275;25283;81919;84493;84032;113902;297594;114494;24232;116599;25612;29657;29221;81639;252898 TWF2_10109;TTK_32727;TOP2A_10059;THY1_33010;SMAD1_32578;PPIC_9541;PPARD_9536;POLE2_9520;PLOD3_9507;PIK3R4_9484;PGR_32824;NS5ATP9_9367;MMS22L_33129;MKI67_9232;MCM3_9207;KIF22_8963;HERC6_8794;GGT7_33026;GCLC_8699;FUT1_8668;FMO3_8654;COL3A1_8354;CES1D_32914;CDCA3_8260;CCNA2_8221;C3_8175;BLVRA_8151;ASNS_8091;ARNTL_8086;ARG1_33267;ALOX15_8036;ACOX2_32902 276.7102281334876 164.772 297.07182712603765 164.7818518834876 88.16165000000001 200.35595379814953 740.0813937584877 447.062 799.7472199064417 138.399;737.351;86.3883;5.72311E-12;21.9973;628.678;94.1074;2.71598E-7;882.629;955.628;283.618;292.216;126.653;21.9311;197.273;17.3097;39.6865;109.609;131.7;240.861;418.073;212.603;11.0684;56.6562;14.384;234.759;415.991;191.145;22.9134;760.927;766.819;743.353 90.7363;446.625;26.6888;5.72311E-12;5.02186;389.239;37.7692;2.71598E-7;625.677;735.228;138.711;147.515;85.587;6.82654;116.413;3.12114;15.7729;29.3336;39.9158;78.9726;293.29;119.81;4.18343;22.3266;4.89199;129.148;288.048;113.564;11.4115;413.607;421.048;432.537 299.165;2108.09;262.273;5.72313E-12;80.1461;1509.86;148.485;2.71599E-7;1106.02;1288.97;1554.21;658.494;240.486;76.1794;496.915;90.6321;157.407;346.073;397.209;847.87;712.184;1510.69;17.0564;150.565;58.2504;694.216;720.942;510.267;50.1592;2639.93;2662.07;2287.79 0 Exp 2,8(0.2);Exp 4,13(0.32);Exp 5,2(0.05);Hill,6(0.15);Linear,2(0.05);Poly 2,9(0.22);Power,1(0.03) 1.9787996140548036 94.20253586769104 1.5018656253814697 15.48720932006836 2.2491786046526436 1.7775747776031494 164.40157777844988 351.1434563811405 91.78259148488144 213.84346608934322 428.90828697850645 912.8489471810843 DOWN 0.21951219512195122 0.7804878048780488 0.0 GO:0030449 6 regulation of complement activation 8 10 2 2 2 2 2 2 66 8 2471 0.99809 0.027525 0.027525 20.0 295703;24232 serping1;c3 SERPING1_32597;C3_8175 133.57935 133.57935 32.3997 143.0896332661629 119.88694722222223 141.773337975048 71.43939999999999 71.43939999999999 13.7308 81.61228478556399 63.629831623931615 80.86152553272184 396.85225 396.85225 99.4885 420.53584820812245 356.61071688034184 416.667298515835 0.0 32.3997 0.0 32.3997 32.3997;234.759 13.7308;129.148 99.4885;694.216 0 2 0 2 295703;24232 SERPING1_32597;C3_8175 133.57935 133.57935 143.0896332661629 71.43939999999999 71.43939999999999 81.61228478556399 396.85225 396.85225 420.53584820812245 32.3997;234.759 13.7308;129.148 99.4885;694.216 0 Exp 4,1(0.5);Poly 2,1(0.5) 1.6302841550800038 3.2650784254074097 1.5467612743377686 1.7183171510696411 0.12130832378951054 1.6325392127037048 -64.73276399999997 331.891464 -41.669456 184.54825599999998 -185.9807 979.6851999999999 DOWN 0.0 1.0 0.0 GO:0043066 8 negative regulation of apoptotic process 279 296 24 23 15 17 13 13 55 283 2196 0.97842 0.04562 0.055963 4.39 688621;24832;25671;25682;25154;24314;81687;24426;25283;24367;24854;246142;25612 tslp;thy1;smad1;ppard;pgr;nqo1;mmp9;gstp1;gclc;fgg;clu;bmf;asns TSLP_32811;THY1_33010;SMAD1_32578;PPARD_9536;PGR_32824;NQO1_33055;MMP9_32531;GSTP1_8762;GCLC_8699;FGG_8639;CLU_32773;BMF_8152;ASNS_8091 225.6549461538466 119.401 5.72311E-12 292.0216425716237 230.61553342844073 279.420052673598 150.03409384615426 39.9158 5.72311E-12 234.4267502770506 149.05745503097174 217.19804833852643 522.3724000000004 220.085 5.72313E-12 645.4953327657407 526.9179055881616 633.8752778553362 344.675;5.72311E-12;21.9973;94.1074;283.618;25.6813;728.316;14.7631;131.7;42.4612;935.649;119.401;191.145 244.2;5.72311E-12;5.02186;37.7692;138.711;7.73944;443.137;9.42992;39.9158;20.6424;808.484;81.8286;113.564 560.435;5.72313E-12;80.1461;148.485;1554.21;86.1211;2039.06;25.7196;397.209;98.0534;1071.05;220.085;510.267 2 11 2 24314;24426 NQO1_33055;GSTP1_8762 20.2222 20.2222 7.720333258350962 8.584679999999999 8.584679999999999 1.1953498714602508 55.92035 55.92035 42.710310243839245 25.6813;14.7631 7.73944;9.42992 86.1211;25.7196 11 688621;24832;25671;25682;25154;81687;25283;24367;24854;246142;25612 TSLP_32811;THY1_33010;SMAD1_32578;PPARD_9536;PGR_32824;MMP9_32531;GCLC_8699;FGG_8639;CLU_32773;BMF_8152;ASNS_8091 263.00635454545505 131.7 303.89281696599943 175.7521690909096 81.8286 247.42229070803285 607.1818636363641 397.209 669.6172338450945 344.675;5.72311E-12;21.9973;94.1074;283.618;728.316;131.7;42.4612;935.649;119.401;191.145 244.2;5.72311E-12;5.02186;37.7692;138.711;443.137;39.9158;20.6424;808.484;81.8286;113.564 560.435;5.72313E-12;80.1461;148.485;1554.21;2039.06;397.209;98.0534;1071.05;220.085;510.267 0 Exp 2,1(0.08);Exp 4,3(0.24);Exp 5,1(0.08);Hill,3(0.24);Linear,1(0.08);Poly 2,4(0.31) 1.9589571257890286 26.230034232139587 1.5405861139297485 3.5281898975372314 0.5666121227413067 1.863204002380371 66.91017296608305 384.39971934161014 22.59826075461399 277.46992693769454 171.47714000732685 873.267659992674 DOWN 0.15384615384615385 0.8461538461538461 0.0 GO:0048523 5 negative regulation of cellular process 938 999 62 59 37 41 28 28 40 971 1508 0.67965 0.41426 0.80143 2.8 684352;315852;688621;360243;24832;25671;295703;25682;25154;259241;24314;316351;81687;24426;25283;24367;312495;245920;84032;24854;306575;29397;24232;246142;25612;29657;29221;170913 twf2;ttk;tslp;top2a;thy1;smad1;serping1;ppard;pgr;nr1d2;nqo1;npas2;mmp9;gstp1;gclc;fgg;cyp26b1;cxcl10;col3a1;clu;ckap2;ccl11;c3;bmf;asns;arntl;arg1;abcb1a TWF2_10109;TTK_32727;TSLP_32811;TOP2A_10059;THY1_33010;SMAD1_32578;SERPING1_32597;PPARD_9536;PGR_32824;NR1D2_9358;NQO1_33055;NPAS2_9350;MMP9_32531;GSTP1_8762;GCLC_8699;FGG_8639;CYP26B1_8418;CXCL10_8408;COL3A1_8354;CLU_32773;CKAP2_8324;CCL11_33230;C3_8175;BMF_8152;ASNS_8091;ARNTL_8086;ARG1_33267;ABCB1A_7938 254.42596785714304 125.5505 5.72311E-12 309.8518129623554 243.35583789992606 302.1670195833137 153.14187821428592 60.87219999999999 5.72311E-12 207.89400963386302 145.29438081522443 200.8125858290726 730.1284142857145 280.71900000000005 5.72313E-12 841.882329591362 686.7142487301862 825.5768635171252 138.399;737.351;344.675;86.3883;5.72311E-12;21.9973;32.3997;94.1074;283.618;29.1728;25.6813;21.0878;728.316;14.7631;131.7;42.4612;18.1872;670.528;212.603;935.649;32.2386;986.476;234.759;119.401;191.145;22.9134;760.927;206.982 90.7363;446.625;244.2;26.6888;5.72311E-12;5.02186;13.7308;37.7692;138.711;3.35457;7.73944;11.3305;443.137;9.42992;39.9158;20.6424;10.0176;374.802;119.81;808.484;15.2683;552.974;129.148;81.8286;113.564;11.4115;413.607;118.025 299.165;2108.09;560.435;262.273;5.72313E-12;80.1461;99.4885;148.485;1554.21;114.038;86.1211;43.5624;2039.06;25.7196;397.209;98.0534;36.7271;1955.3;1510.69;1071.05;76.7052;2230.86;694.216;220.085;510.267;50.1592;2639.93;1531.55 5 23 5 259241;24314;24426;312495;29397 NR1D2_9358;NQO1_33055;GSTP1_8762;CYP26B1_8418;CCL11_33230 214.85608000000002 25.6813 431.38687039771736 116.703106 9.42992 243.89680076731673 498.69316 86.1211 968.9806354429707 29.1728;25.6813;14.7631;18.1872;986.476 3.35457;7.73944;9.42992;10.0176;552.974 114.038;86.1211;25.7196;36.7271;2230.86 23 684352;315852;688621;360243;24832;25671;295703;25682;25154;316351;81687;25283;24367;245920;84032;24854;306575;24232;246142;25612;29657;29221;170913 TWF2_10109;TTK_32727;TSLP_32811;TOP2A_10059;THY1_33010;SMAD1_32578;SERPING1_32597;PPARD_9536;PGR_32824;NPAS2_9350;MMP9_32531;GCLC_8699;FGG_8639;CXCL10_8408;COL3A1_8354;CLU_32773;CKAP2_8324;C3_8175;BMF_8152;ASNS_8091;ARNTL_8086;ARG1_33267;ABCB1A_7938 263.0281173913046 138.399 289.06672739417405 161.06335043478285 90.7363 204.5963939981074 780.4404260869567 397.209 827.233972547321 138.399;737.351;344.675;86.3883;5.72311E-12;21.9973;32.3997;94.1074;283.618;21.0878;728.316;131.7;42.4612;670.528;212.603;935.649;32.2386;234.759;119.401;191.145;22.9134;760.927;206.982 90.7363;446.625;244.2;26.6888;5.72311E-12;5.02186;13.7308;37.7692;138.711;11.3305;443.137;39.9158;20.6424;374.802;119.81;808.484;15.2683;129.148;81.8286;113.564;11.4115;413.607;118.025 299.165;2108.09;560.435;262.273;5.72313E-12;80.1461;99.4885;148.485;1554.21;43.5624;2039.06;397.209;98.0534;1955.3;1510.69;1071.05;76.7052;694.216;220.085;510.267;50.1592;2639.93;1531.55 0 Exp 2,3(0.11);Exp 4,10(0.36);Exp 5,1(0.04);Hill,3(0.11);Linear,2(0.08);Poly 2,8(0.29);Power,1(0.04) 1.95849139506686 56.469006180763245 1.5111545324325562 3.5281898975372314 0.5490757670656777 1.875340223312378 139.65525020381813 369.1966855104679 76.13685941710847 230.14689701146344 418.2908354667304 1041.9659931046986 DOWN 0.17857142857142858 0.8214285714285714 0.0 GO:0048660 6 regulation of smooth muscle cell proliferation 79 82 8 8 4 6 3 3 65 79 2400 0.82638 0.37579 0.4806 3.66 25682;81687;24426 ppard;mmp9;gstp1 PPARD_9536;MMP9_32531;GSTP1_8762 279.06216666666666 94.1074 14.7631 391.0826441548428 383.876046993431 411.3323270714049 163.44537333333332 37.7692 9.42992 242.63415509427796 228.1140320768064 256.16838764880583 737.7548666666667 148.485 25.7196 1128.6337419149993 1038.3824650833753 1191.9750654966888 94.1074;728.316;14.7631 37.7692;443.137;9.42992 148.485;2039.06;25.7196 1 2 1 24426 GSTP1_8762 14.7631 14.7631 9.42992 9.42992 25.7196 25.7196 14.7631 9.42992 25.7196 2 25682;81687 PPARD_9536;MMP9_32531 411.2117 411.2117 448.45320174682666 240.4531 240.4531 286.6383202546721 1093.7725 1093.7725 1336.8384028417568 94.1074;728.316 37.7692;443.137 148.485;2039.06 0 Exp 4,1(0.34);Exp 5,1(0.34);Linear,1(0.34) 2.412026468532604 7.518435597419739 1.9388991594314575 3.5281898975372314 0.8869005736361267 2.05134654045105 -163.48950629458386 721.6138396279173 -111.12102039289306 438.01176705955976 -539.4144429671276 2014.9241763004609 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0032465 6 regulation of cytokinesis 27 28 4 4 4 2 2 2 66 26 2453 0.96298 0.17069 0.17069 7.14 363131;361921 pik3r4;ect2 PIK3R4_9484;ECT2_8523 482.82210000000003 482.82210000000003 10.0162 668.6485161500174 219.29939304663841 555.1598004084639 369.26102499999996 369.26102499999996 3.29405 517.5554594256554 165.28597327680194 429.7115429335575 663.35025 663.35025 37.7305 884.7599353384652 314.65534149000604 734.5909506239094 0.5 482.82210000000003 955.628;10.0162 735.228;3.29405 1288.97;37.7305 0 2 0 2 363131;361921 PIK3R4_9484;ECT2_8523 482.82210000000003 482.82210000000003 668.6485161500174 369.26102499999996 369.26102499999996 517.5554594256554 663.35025 663.35025 884.7599353384652 955.628;10.0162 735.228;3.29405 1288.97;37.7305 0 Exp 4,1(0.5);Poly 2,1(0.5) 1.5674198447786372 3.1377010345458984 1.5018656253814697 1.6358354091644287 0.09473094258702586 1.5688505172729492 -443.877464 1409.521664 -348.0342459999999 1086.5562959999997 -562.86446 1889.56496 DOWN 0.0 1.0 0.0 GO:0042981 7 regulation of apoptotic process 428 455 34 33 20 23 16 16 52 439 2040 0.91497 0.14166 0.2594 3.52 688621;360243;24832;25671;25682;25154;24314;81687;24426;25283;24367;361921;245920;24854;246142;25612 tslp;top2a;thy1;smad1;ppard;pgr;nqo1;mmp9;gstp1;gclc;fgg;ect2;cxcl10;clu;bmf;asns TSLP_32811;TOP2A_10059;THY1_33010;SMAD1_32578;PPARD_9536;PGR_32824;NQO1_33055;MMP9_32531;GSTP1_8762;GCLC_8699;FGG_8639;ECT2_8523;CXCL10_8408;CLU_32773;BMF_8152;ASNS_8091 231.27792500000035 106.7542 5.72311E-12 292.8732481372818 208.02809015990482 267.719009331968 147.20175437500038 38.8425 5.72311E-12 223.10084031130785 130.57642364298047 204.02190770897192 565.3840437500004 241.17900000000003 5.72313E-12 698.8648723683643 489.5629911877766 620.2728879650924 344.675;86.3883;5.72311E-12;21.9973;94.1074;283.618;25.6813;728.316;14.7631;131.7;42.4612;10.0162;670.528;935.649;119.401;191.145 244.2;26.6888;5.72311E-12;5.02186;37.7692;138.711;7.73944;443.137;9.42992;39.9158;20.6424;3.29405;374.802;808.484;81.8286;113.564 560.435;262.273;5.72313E-12;80.1461;148.485;1554.21;86.1211;2039.06;25.7196;397.209;98.0534;37.7305;1955.3;1071.05;220.085;510.267 2 14 2 24314;24426 NQO1_33055;GSTP1_8762 20.2222 20.2222 7.720333258350962 8.584679999999999 8.584679999999999 1.1953498714602508 55.92035 55.92035 42.710310243839245 25.6813;14.7631 7.73944;9.42992 86.1211;25.7196 14 688621;360243;24832;25671;25682;25154;81687;25283;24367;361921;245920;24854;246142;25612 TSLP_32811;TOP2A_10059;THY1_33010;SMAD1_32578;PPARD_9536;PGR_32824;MMP9_32531;GCLC_8699;FGG_8639;ECT2_8523;CXCL10_8408;CLU_32773;BMF_8152;ASNS_8091 261.4287428571432 125.5505 301.8845226262585 167.00419357142897 60.87219999999999 232.4930183174235 638.1645714285718 329.741 719.566797745402 344.675;86.3883;5.72311E-12;21.9973;94.1074;283.618;728.316;131.7;42.4612;10.0162;670.528;935.649;119.401;191.145 244.2;26.6888;5.72311E-12;5.02186;37.7692;138.711;443.137;39.9158;20.6424;3.29405;374.802;808.484;81.8286;113.564 560.435;262.273;5.72313E-12;80.1461;148.485;1554.21;2039.06;397.209;98.0534;37.7305;1955.3;1071.05;220.085;510.267 0 Exp 2,2(0.13);Exp 4,5(0.32);Exp 5,1(0.07);Hill,3(0.19);Linear,1(0.07);Poly 2,4(0.25) 1.9304280492647534 31.68000900745392 1.5405861139297485 3.5281898975372314 0.5167736190867336 1.8585044145584106 87.77003341273232 374.7858165872684 37.882342622459504 256.52116612754116 222.94025628950175 907.8278312104987 DOWN 0.125 0.875 0.0 GO:0071417 5 cellular response to organonitrogen compound 203 213 15 15 9 12 8 8 60 205 2274 0.89018 0.20397 0.27041 3.76 25154;362282;24426;25283;84032;114494;29221;170913 pgr;pck1;gstp1;gclc;col3a1;ccna2;arg1;abcb1a PGR_32824;PCK1_9439;GSTP1_8762;GCLC_8699;COL3A1_8354;CCNA2_8221;ARG1_33267;ABCB1A_7938 269.2776375 209.79250000000002 14.384 257.813896012209 239.80276092219998 260.5552469877135 150.15921375 118.9175 4.89199 154.58937065606187 124.93309503936565 149.65373551239807 1092.327375 1265.875 25.7196 900.126116116926 1031.2820179981375 961.2162775621576 283.618;529.244;14.7631;131.7;212.603;14.384;760.927;206.982 138.711;356.883;9.42992;39.9158;119.81;4.89199;413.607;118.025 1554.21;1021.06;25.7196;397.209;1510.69;58.2504;2639.93;1531.55 2 6 2 362282;24426 PCK1_9439;GSTP1_8762 272.00355 272.00355 363.7929331809581 183.15645999999998 183.15645999999998 245.686429012152 523.3897999999999 523.3897999999999 703.8119464289307 529.244;14.7631 356.883;9.42992 1021.06;25.7196 6 25154;25283;84032;114494;29221;170913 PGR_32824;GCLC_8699;COL3A1_8354;CCNA2_8221;ARG1_33267;ABCB1A_7938 268.36899999999997 209.79250000000002 258.0352385531868 139.16013166666667 118.9175 144.23576385757875 1281.9732333333334 1521.12 928.7695818105188 283.618;131.7;212.603;14.384;760.927;206.982 138.711;39.9158;119.81;4.89199;413.607;118.025 1554.21;397.209;1510.69;58.2504;2639.93;1531.55 0 Exp 2,1(0.13);Exp 4,2(0.25);Hill,1(0.13);Linear,1(0.13);Poly 2,3(0.38) 1.8369647298221203 15.295759677886963 1.513624906539917 3.5281898975372314 0.6734088546373206 1.6198903322219849 90.62172242873078 447.9335525712693 43.03424530554321 257.2841821944568 468.5717999831994 1716.0829500168002 DOWN 0.25 0.75 0.0 GO:0030199 6 collagen fibril organization 14 16 2 2 2 2 2 2 66 14 2465 0.99205 0.066251 0.066251 12.5 288583;84032 plod3;col3a1 PLOD3_9507;COL3A1_8354 547.616 547.616 212.603 473.77992817129774 484.9611932792584 465.4204236253207 372.74350000000004 372.74350000000004 119.81 357.7019860784952 325.4393668597914 351.39059295918395 1308.355 1308.355 1106.02 286.14490114276066 1346.1960996523753 281.09608109007644 0.0 212.603 0.5 547.616 882.629;212.603 625.677;119.81 1106.02;1510.69 0 2 0 2 288583;84032 PLOD3_9507;COL3A1_8354 547.616 547.616 473.77992817129774 372.74350000000004 372.74350000000004 357.7019860784952 1308.355 1308.355 286.14490114276066 882.629;212.603 625.677;119.81 1106.02;1510.69 0 Poly 2,2(1) 1.6637289984455534 3.329054355621338 1.6129854917526245 1.7160688638687134 0.0728909514508627 1.664527177810669 -109.00947999999994 1204.24148 -123.00615999999991 868.49316 911.7783999999999 1704.9316000000001 DOWN 0.0 1.0 0.0 GO:0051384 7 response to glucocorticoid 119 133 12 11 7 9 6 6 62 127 2352 0.93856 0.14109 0.16589 4.51 362282;24426;25315;24232;29221;170913 pck1;gstp1;ephx1;c3;arg1;abcb1a PCK1_9439;GSTP1_8762;EPHX1_8567;C3_8175;ARG1_33267;ABCB1A_7938 297.6522 220.8705 14.7631 292.31456751047494 299.02699361814575 307.9330794403552 174.34193666666667 123.5865 9.42992 171.5360155068272 167.7416707271526 171.12729291684343 999.0286833333333 857.6379999999999 25.7196 985.7343598410282 1199.1969357542391 1075.6040157203215 529.244;14.7631;39.2381;234.759;760.927;206.982 356.883;9.42992;18.9587;129.148;413.607;118.025 1021.06;25.7196;81.6965;694.216;2639.93;1531.55 3 3 3 362282;24426;25315 PCK1_9439;GSTP1_8762;EPHX1_8567 194.4150666666667 39.2381 290.22847440267356 128.42387333333332 18.9587 197.9087639040882 376.15869999999995 81.6965 559.2017689436166 529.244;14.7631;39.2381 356.883;9.42992;18.9587 1021.06;25.7196;81.6965 3 24232;29221;170913 C3_8175;ARG1_33267;ABCB1A_7938 400.88933333333335 234.759 312.11092819113736 220.26 129.148 167.5357486896454 1621.8986666666667 1531.55 975.9984137411973 234.759;760.927;206.982 129.148;413.607;118.025 694.216;2639.93;1531.55 0 Exp 2,1(0.17);Exp 4,2(0.34);Linear,1(0.17);Poly 2,2(0.34) 1.9286372908450244 12.135897159576416 1.513624906539917 3.5281898975372314 0.7668480783336076 1.7494444847106934 63.75183197088364 531.5525680291164 37.084537902722616 311.5993354306107 210.27692351041674 1787.78044315625 CONFLICT 0.5 0.5 0.0 GO:0045931 7 positive regulation of mitotic cell cycle 58 63 2 2 2 2 2 2 66 61 2418 0.7643 0.50663 0.68459 3.17 24296;25612 cyp1a1;asns CYP1A1_8415;ASNS_8091 102.01565000000001 102.01565000000001 12.8863 126.0479355754984 131.8546063043478 118.77438880574988 61.34768 61.34768 9.13136 73.84502792121349 78.82879582608695 69.58382949820071 264.7952 264.7952 19.3234 347.14954874013586 346.9748895652174 327.11741995254386 12.8863;191.145 9.13136;113.564 19.3234;510.267 1 1 1 24296 CYP1A1_8415 12.8863 12.8863 9.13136 9.13136 19.3234 19.3234 12.8863 9.13136 19.3234 1 25612 ASNS_8091 191.145 191.145 113.564 113.564 510.267 510.267 191.145 113.564 510.267 0 Exp 4,1(0.5);Poly 2,1(0.5) 5.287751527771803 17.292590498924255 1.805381178855896 15.48720932006836 9.67451345768027 8.646295249462128 -72.67787599999996 276.70917599999996 -40.996307199999976 163.69166719999998 -216.32952799999993 745.919928 CONFLICT 0.5 0.5 0.0 GO:0070417 5 cellular response to cold 3 3 1 1 1 1 1 1 67 2 2477 0.99793 0.078005 0.078005 33.33 116669 vwf VWF_32396 19.6764 19.6764 19.6764 19.6764 4.11644 4.11644 4.11644 4.11644 94.078 94.078 94.078 94.078 0.0 19.6764 0.0 19.6764 19.6764 4.11644 94.078 0 1 0 1 116669 VWF_32396 19.6764 19.6764 4.11644 4.11644 94.078 94.078 19.6764 4.11644 94.078 0 Hill,1(1) 2.0912885665893555 2.0912885665893555 2.0912885665893555 2.0912885665893555 0.0 2.0912885665893555 19.6764 19.6764 4.11644 4.11644 94.078 94.078 DOWN 0.0 1.0 0.0 GO:2000298 9 regulation of Rho-dependent protein serine/threonine kinase activity 2 2 1 1 1 1 1 1 67 1 2478 0.9993 0.052694 0.052694 50.0 24832 thy1 THY1_33010 5.72311E-12 5.72311E-12 5.72311E-12 5.7231099999999994E-12 5.72311E-12 5.72311E-12 5.72311E-12 5.7231099999999994E-12 5.72313E-12 5.72313E-12 5.72313E-12 5.723129999999999E-12 0.0 5.72311E-12 0.0 5.72311E-12 5.72311E-12 5.72311E-12 5.72313E-12 0 1 0 1 24832 THY1_33010 5.72311E-12 5.72311E-12 5.72311E-12 5.72311E-12 5.72313E-12 5.72313E-12 5.72311E-12 5.72311E-12 5.72313E-12 0 Hill,1(1) 1.863204002380371 1.863204002380371 1.863204002380371 1.863204002380371 0.0 1.863204002380371 5.72311E-12 5.72311E-12 5.72311E-12 5.72311E-12 5.72313E-12 5.72313E-12 DOWN 0.0 1.0 0.0 GO:0009968 6 negative regulation of signal transduction 284 297 20 19 14 12 10 10 58 287 2192 0.83864 0.264 0.44129 3.37 24832;81687;24426;25283;24367;312495;24854;246142;29657;29221 thy1;mmp9;gstp1;gclc;fgg;cyp26b1;clu;bmf;arntl;arg1 THY1_33010;MMP9_32531;GSTP1_8762;GCLC_8699;FGG_8639;CYP26B1_8418;CLU_32773;BMF_8152;ARNTL_8086;ARG1_33267 277.43179000000055 80.9311 5.72311E-12 372.6313869602693 285.20561977006304 355.9910256267106 183.84738200000055 30.2791 5.72311E-12 277.313246141542 180.09344586359109 256.62174879937163 657.7993300000005 159.0692 5.72313E-12 952.6278155546765 718.6013228857703 960.9445944889011 5.72311E-12;728.316;14.7631;131.7;42.4612;18.1872;935.649;119.401;22.9134;760.927 5.72311E-12;443.137;9.42992;39.9158;20.6424;10.0176;808.484;81.8286;11.4115;413.607 5.72313E-12;2039.06;25.7196;397.209;98.0534;36.7271;1071.05;220.085;50.1592;2639.93 2 8 2 24426;312495 GSTP1_8762;CYP26B1_8418 16.47515 16.47515 2.421204329460879 9.723759999999999 9.723759999999999 0.4155525131677724 31.22335 31.22335 7.783477893910919 14.7631;18.1872 9.42992;10.0176 25.7196;36.7271 8 24832;81687;25283;24367;24854;246142;29657;29221 THY1_33010;MMP9_32531;GCLC_8699;FGG_8639;CLU_32773;BMF_8152;ARNTL_8086;ARG1_33267 342.6709500000007 125.5505 392.68954891705783 227.37828750000074 60.87219999999999 296.72641712530566 814.4433250000006 308.647 1013.1946340592883 5.72311E-12;728.316;131.7;42.4612;935.649;119.401;22.9134;760.927 5.72311E-12;443.137;39.9158;20.6424;808.484;81.8286;11.4115;413.607 5.72313E-12;2039.06;397.209;98.0534;1071.05;220.085;50.1592;2639.93 0 Exp 2,1(0.1);Exp 4,4(0.4);Hill,2(0.2);Linear,1(0.1);Poly 2,2(0.2) 2.1424628292569805 22.4402517080307 1.513624906539917 3.5281898975372314 0.7537143367855237 2.0130178332328796 46.472463549444996 508.3911164505562 11.96685130413465 355.7279126958665 67.35449272162339 1248.2441672783775 DOWN 0.2 0.8 0.0 GO:0090276 6 regulation of peptide hormone secretion 58 63 5 5 3 4 3 3 65 60 2419 0.91461 0.2357 0.2357 4.76 25682;24367;29657 ppard;fgg;arntl PPARD_9536;FGG_8639;ARNTL_8086 53.160666666666664 42.4612 22.9134 36.78322102825326 57.52598180453635 32.14986706562088 23.274366666666666 20.6424 11.4115 13.374510223680465 25.36563768345563 11.138349615514832 98.89920000000001 98.0534 50.1592 49.168356385382666 109.90778233822549 37.233596123577335 94.1074;42.4612;22.9134 37.7692;20.6424;11.4115 148.485;98.0534;50.1592 0 3 0 3 25682;24367;29657 PPARD_9536;FGG_8639;ARNTL_8086 53.160666666666664 42.4612 36.78322102825326 23.274366666666666 20.6424 13.374510223680465 98.89920000000001 98.0534 49.168356385382666 94.1074;42.4612;22.9134 37.7692;20.6424;11.4115 148.485;98.0534;50.1592 0 Exp 4,2(0.67);Exp 5,1(0.34) 2.659448713846792 8.199516654014587 1.9388991594314575 3.442979335784912 0.755589283665696 2.8176381587982178 11.536533644512545 94.78479968882078 8.139683593940882 38.40904973939245 43.2599669623642 154.5384330376358 DOWN 0.0 1.0 0.0 GO:0007059 3 chromosome segregation 37 37 6 6 5 3 3 3 65 34 2445 0.98419 0.074193 0.074193 8.11 315852;360243;295661 ttk;top2a;spc25 TTK_32727;TOP2A_10059;SPC25_9925 286.5432 86.3883 35.8903 391.2266177123305 182.91957030635186 323.9793386500575 161.6294 26.6888 11.5744 246.92909971560664 97.07288479482855 203.68174397179752 831.4563333333334 262.273 124.006 1107.7565526650399 538.2752510773843 917.0969548499226 0.5 61.139300000000006 737.351;86.3883;35.8903 446.625;26.6888;11.5744 2108.09;262.273;124.006 0 3 0 3 315852;360243;295661 TTK_32727;TOP2A_10059;SPC25_9925 286.5432 86.3883 391.2266177123305 161.6294 26.6888 246.92909971560664 831.4563333333334 262.273 1107.7565526650399 737.351;86.3883;35.8903 446.625;26.6888;11.5744 2108.09;262.273;124.006 0 Exp 4,2(0.67);Linear,1(0.34) 1.6774564714078277 5.064851999282837 1.5111545324325562 1.9603345394134521 0.23916140396437222 1.5933629274368286 -156.1713943787072 729.2577943787072 -117.79718109545254 441.0559810954526 -422.0882126670224 2085.000879333689 DOWN 0.0 1.0 0.0 GO:2001237 8 negative regulation of extrinsic apoptotic signaling pathway 46 48 5 5 3 4 3 3 65 45 2434 0.96255 0.13477 0.13477 6.25 24426;25283;24367 gstp1;gclc;fgg GSTP1_8762;GCLC_8699;FGG_8639 62.97476666666666 42.4612 14.7631 61.10781012639327 79.00696376594148 60.958259937243774 23.329373333333333 20.6424 9.42992 15.419535956510927 27.6446991726503 14.703862837588526 173.66066666666666 98.0534 25.7196 196.94780439927055 224.06009038688245 198.97447188425346 1.5 87.08059999999999 14.7631;131.7;42.4612 9.42992;39.9158;20.6424 25.7196;397.209;98.0534 1 2 1 24426 GSTP1_8762 14.7631 14.7631 9.42992 9.42992 25.7196 25.7196 14.7631 9.42992 25.7196 2 25283;24367 GCLC_8699;FGG_8639 87.08059999999999 87.08059999999999 63.101360624950075 30.2791 30.2791 13.628351836520793 247.6312 247.6312 211.5349533899303 131.7;42.4612 39.9158;20.6424 397.209;98.0534 0 Exp 4,2(0.67);Hill,1(0.34) 2.6976067252594436 8.320517182350159 1.9746891260147095 3.5281898975372314 0.7776901152790828 2.8176381587982178 -6.175230160414259 132.1247634937476 5.880525792202768 40.7782208744639 -49.2067543903336 396.5280877236669 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0051049 5 regulation of transport 454 483 31 29 20 20 16 16 52 467 2012 0.86956 0.20402 0.34618 3.31 688621;24832;25682;81687;25283;24367;361921;245920;24854;113902;686019;24232;29657;29221;81639;170913 tslp;thy1;ppard;mmp9;gclc;fgg;ect2;cxcl10;clu;ces1d;casq1;c3;arntl;arg1;alox15;abcb1a TSLP_32811;THY1_33010;PPARD_9536;MMP9_32531;GCLC_8699;FGG_8639;ECT2_8523;CXCL10_8408;CLU_32773;CES1D_32914;CASQ1_32992;C3_8175;ARNTL_8086;ARG1_33267;ALOX15_8036;ABCB1A_7938 319.28635000000037 177.321 5.72311E-12 332.53786979336115 313.43198432784743 317.27343890769475 197.89185500000036 107.31365 5.72311E-12 233.15884769702802 192.04520106535156 219.697423854194 886.7548437500004 478.822 5.72313E-12 966.7683308872574 897.1880485811375 954.8161241920975 344.675;5.72311E-12;94.1074;728.316;131.7;42.4612;10.0162;670.528;935.649;11.0684;147.66;234.759;22.9134;760.927;766.819;206.982 244.2;5.72311E-12;37.7692;443.137;39.9158;20.6424;3.29405;374.802;808.484;4.18343;96.6023;129.148;11.4115;413.607;421.048;118.025 560.435;5.72313E-12;148.485;2039.06;397.209;98.0534;37.7305;1955.3;1071.05;17.0564;285.773;694.216;50.1592;2639.93;2662.07;1531.55 0 16 0 16 688621;24832;25682;81687;25283;24367;361921;245920;24854;113902;686019;24232;29657;29221;81639;170913 TSLP_32811;THY1_33010;PPARD_9536;MMP9_32531;GCLC_8699;FGG_8639;ECT2_8523;CXCL10_8408;CLU_32773;CES1D_32914;CASQ1_32992;C3_8175;ARNTL_8086;ARG1_33267;ALOX15_8036;ABCB1A_7938 319.28635000000037 177.321 332.53786979336115 197.89185500000036 107.31365 233.15884769702802 886.7548437500004 478.822 966.7683308872574 344.675;5.72311E-12;94.1074;728.316;131.7;42.4612;10.0162;670.528;935.649;11.0684;147.66;234.759;22.9134;760.927;766.819;206.982 244.2;5.72311E-12;37.7692;443.137;39.9158;20.6424;3.29405;374.802;808.484;4.18343;96.6023;129.148;11.4115;413.607;421.048;118.025 560.435;5.72313E-12;148.485;2039.06;397.209;98.0534;37.7305;1955.3;1071.05;17.0564;285.773;694.216;50.1592;2639.93;2662.07;1531.55 0 Exp 2,4(0.25);Exp 4,3(0.19);Exp 5,2(0.13);Hill,2(0.13);Linear,1(0.07);Poly 2,4(0.25) 1.8979927534176875 31.223161101341248 1.5021449327468872 3.442979335784912 0.5252416317633775 1.8585044145584106 156.3427938012534 482.22990619874736 83.6440196284566 312.1396903715441 413.0383616152441 1360.4713258847564 DOWN 0.0 1.0 0.0 GO:0045766 7 positive regulation of angiogenesis 68 69 9 9 6 7 5 5 63 64 2415 0.99075 0.035136 0.035136 7.25 25671;81687;81919;29397;24232 smad1;mmp9;fut1;ccl11;c3 SMAD1_32578;MMP9_32531;FUT1_8668;CCL11_33230;C3_8175 442.48186000000004 240.861 21.9973 399.4489338125688 526.6694384166882 363.80732961197833 241.85069199999998 129.148 5.02186 241.1601935815825 285.3621463254729 232.93295421020875 1178.4304200000001 847.87 80.1461 921.717627339622 1428.3886704543488 795.8789491410757 2.5 484.5885 21.9973;728.316;240.861;986.476;234.759 5.02186;443.137;78.9726;552.974;129.148 80.1461;2039.06;847.87;2230.86;694.216 1 4 1 29397 CCL11_33230 986.476 986.476 552.974 552.974 2230.86 2230.86 986.476 552.974 2230.86 4 25671;81687;81919;24232 SMAD1_32578;MMP9_32531;FUT1_8668;C3_8175 306.48332500000004 237.81 299.068427205251 164.069865 104.0603 192.90396133581316 915.323025 771.043 819.2971606038531 21.9973;728.316;240.861;234.759 5.02186;443.137;78.9726;129.148 80.1461;2039.06;847.87;694.216 0 Exp 2,1(0.2);Exp 4,1(0.2);Linear,1(0.2);Poly 2,1(0.2);Power,1(0.2) 1.9628541442177718 10.00981068611145 1.5467612743377686 2.737008571624756 0.4598053840516239 1.9814788103103638 92.3494319384705 792.6142880615295 30.464462164352682 453.2369218356473 370.5092978498443 1986.3515421501556 DOWN 0.2 0.8 0.0 GO:2000026 5 regulation of multicellular organismal development 487 514 38 36 22 23 16 16 52 498 1981 0.80482 0.28629 0.44805 3.11 684352;24832;25671;25682;338475;259241;81687;81919;361921;312495;245920;84032;29397;24232;29657;170913 twf2;thy1;smad1;ppard;nrep;nr1d2;mmp9;fut1;ect2;cyp26b1;cxcl10;col3a1;ccl11;c3;arntl;abcb1a TWF2_10109;THY1_33010;SMAD1_32578;PPARD_9536;NREP_9364;NR1D2_9358;MMP9_32531;FUT1_8668;ECT2_8523;CYP26B1_8418;CXCL10_8408;COL3A1_8354;CCL11_33230;C3_8175;ARNTL_8086;ABCB1A_7938 229.80383125000037 116.25319999999999 5.72311E-12 299.2754088899689 245.86501571973406 308.9118517009831 125.25909875000036 58.3709 5.72311E-12 173.85558420621402 132.63252522575365 181.96911358468057 732.7990562500004 223.97650000000002 5.72313E-12 830.7763322713784 790.1427270066555 839.8036126712113 138.399;5.72311E-12;21.9973;94.1074;61.543;29.1728;728.316;240.861;10.0162;18.1872;670.528;212.603;986.476;234.759;22.9134;206.982 90.7363;5.72311E-12;5.02186;37.7692;25.6719;3.35457;443.137;78.9726;3.29405;10.0176;374.802;119.81;552.974;129.148;11.4115;118.025 299.165;5.72313E-12;80.1461;148.485;148.788;114.038;2039.06;847.87;37.7305;36.7271;1955.3;1510.69;2230.86;694.216;50.1592;1531.55 3 13 3 259241;312495;29397 NR1D2_9358;CYP26B1_8418;CCL11_33230 344.612 29.1728 555.8976674927139 188.78205666666668 10.0176 315.4170694237673 793.8750333333334 114.038 1245.0656969149072 29.1728;18.1872;986.476 3.35457;10.0176;552.974 114.038;36.7271;2230.86 13 684352;24832;25671;25682;338475;81687;81919;361921;245920;84032;24232;29657;170913 TWF2_10109;THY1_33010;SMAD1_32578;PPARD_9536;NREP_9364;MMP9_32531;FUT1_8668;ECT2_8523;CXCL10_8408;COL3A1_8354;C3_8175;ARNTL_8086;ABCB1A_7938 203.3096384615389 138.399 237.4823021373292 110.59995461538506 78.9726 141.27736663863988 718.7046000000005 299.165 776.6750291936245 138.399;5.72311E-12;21.9973;94.1074;61.543;728.316;240.861;10.0162;670.528;212.603;234.759;22.9134;206.982 90.7363;5.72311E-12;5.02186;37.7692;25.6719;443.137;78.9726;3.29405;374.802;119.81;129.148;11.4115;118.025 299.165;5.72313E-12;80.1461;148.485;148.788;2039.06;847.87;37.7305;1955.3;1510.69;694.216;50.1592;1531.55 0 Exp 2,2(0.13);Exp 4,6(0.38);Exp 5,1(0.07);Hill,1(0.07);Linear,1(0.07);Poly 2,4(0.25);Power,1(0.07) 1.9638138555084967 32.098737478256226 1.5467612743377686 3.442979335784912 0.4757719482435306 1.875340223312378 83.15888089391561 376.44878160608516 40.06986248895551 210.44833501104523 325.71865343702495 1139.8794590629755 DOWN 0.1875 0.8125 0.0 GO:0055088 6 lipid homeostasis 50 52 3 3 3 3 3 3 65 49 2430 0.95185 0.16005 0.16005 5.77 259241;113902;252898 nr1d2;ces1d;acox2 NR1D2_9358;CES1D_32914;ACOX2_32902 261.19806666666665 29.1728 11.0684 417.65653009152544 263.9482767672319 415.32418082009127 146.69166666666666 4.18343 3.35457 247.54966712471705 146.5996602532482 247.67017753478973 806.2948 114.038 17.0564 1283.9284942713593 820.9058548337372 1271.308906805791 1.5 386.2629 29.1728;11.0684;743.353 3.35457;4.18343;432.537 114.038;17.0564;2287.79 1 2 1 259241 NR1D2_9358 29.1728 29.1728 3.35457 3.35457 114.038 114.038 29.1728 3.35457 114.038 2 113902;252898 CES1D_32914;ACOX2_32902 377.2107 377.2107 517.8034064184784 218.36021499999998 218.36021499999998 302.8917140924665 1152.4232 1152.4232 1605.6511268281413 11.0684;743.353 4.18343;432.537 17.0564;2287.79 0 Exp 2,1(0.34);Exp 4,1(0.34);Exp 5,1(0.34) 1.7586768996635382 5.341311931610107 1.5319663286209106 2.1823768615722656 0.3513159783218932 1.6269687414169312 -211.424789084542 733.8209224178753 -133.43715255975837 426.8204858930917 -646.6070651040885 2259.1966651040884 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0071314 6 cellular response to cocaine 1 1 1 1 1 1 1 1 67 0 2479 1.0 0.026698 0.026698 100.0 114494 ccna2 CCNA2_8221 14.384 14.384 14.384 14.384 4.89199 4.89199 4.89199 4.89199 58.2504 58.2504 58.2504 58.250400000000006 0.0 14.384 0.0 14.384 14.384 4.89199 58.2504 0 1 0 1 114494 CCNA2_8221 14.384 14.384 4.89199 4.89199 58.2504 58.2504 14.384 4.89199 58.2504 0 Exp 4,1(1) 1.6267951726913452 1.6267951726913452 1.6267951726913452 1.6267951726913452 0.0 1.6267951726913452 14.384 14.384 4.89199 4.89199 58.2504 58.2504 DOWN 0.0 1.0 0.0 GO:0034622 7 cellular protein-containing complex assembly 125 146 8 8 6 7 5 5 63 141 2338 0.80837 0.35013 0.59108 3.42 25671;316273;24367;24854;686019 smad1;mcm3;fgg;clu;casq1 SMAD1_32578;MCM3_9207;FGG_8639;CLU_32773;CASQ1_32992 269.0081 147.66 21.9973 379.6772342117315 247.32166899342224 351.9913794192952 209.43271199999998 96.6023 5.02186 338.25707408254414 191.2774088506145 313.6666447964803 406.3875 285.773 80.1461 408.0510669847341 370.1802562619007 376.2847623316997 21.9973;197.273;42.4612;935.649;147.66 5.02186;116.413;20.6424;808.484;96.6023 80.1461;496.915;98.0534;1071.05;285.773 0 5 0 5 25671;316273;24367;24854;686019 SMAD1_32578;MCM3_9207;FGG_8639;CLU_32773;CASQ1_32992 269.0081 147.66 379.6772342117315 209.43271199999998 96.6023 338.25707408254414 406.3875 285.773 408.0510669847341 21.9973;197.273;42.4612;935.649;147.66 5.02186;116.413;20.6424;808.484;96.6023 80.1461;496.915;98.0534;1071.05;285.773 0 Exp 4,2(0.4);Poly 2,3(0.6) 1.9356921309767652 9.967067122459412 1.5548590421676636 2.8176381587982178 0.5587454592841481 1.6932154893875122 -63.79366924096382 601.8098692409638 -87.06268611535029 505.92811011535025 48.71496976487924 764.0600302351207 DOWN 0.0 1.0 0.0 GO:0043170 4 macromolecule metabolic process 853 925 56 56 37 36 26 26 42 899 1580 0.68063 0.41451 0.79844 2.81 315852;360243;24832;25671;291463;25682;299112;288583;363131;362282;300795;313108;81687;291234;316273;293502;362376;156275;81919;24367;29243;84032;297594;114494;29397;29657 ttk;top2a;thy1;smad1;ppic;ppard;pole2;plod3;pik3r4;pck1;pclaf;mms22l;mmp9;mki67;mcm3;kif22;herc6;ggt7;fut1;fgg;f10;col3a1;cdca3;ccna2;ccl11;arntl TTK_32727;TOP2A_10059;THY1_33010;SMAD1_32578;PPIC_9541;PPARD_9536;POLE2_9520;PLOD3_9507;PIK3R4_9484;PCK1_9439;NS5ATP9_9367;MMS22L_33129;MMP9_32531;MKI67_9232;MCM3_9207;KIF22_8963;HERC6_8794;GGT7_33026;FUT1_8668;FGG_8639;F10_8585;COL3A1_8354;CDCA3_8260;CCNA2_8221;CCL11_33230;ARNTL_8086 274.98315770275394 106.89949999999999 5.72311E-12 331.0701128873044 216.28485390101315 298.4233574756352 166.16500116429245 38.09605 5.72311E-12 224.83429519566792 122.22185479269916 191.11698005135082 643.8324077027539 251.3795 5.72313E-12 722.9943812315524 550.75043228221 719.3403269682557 737.351;86.3883;5.72311E-12;21.9973;628.678;94.1074;2.71598E-7;882.629;955.628;529.244;292.216;126.653;728.316;21.9311;197.273;17.3097;39.6865;109.609;240.861;42.4612;104.19;212.603;56.6562;14.384;986.476;22.9134 446.625;26.6888;5.72311E-12;5.02186;389.239;37.7692;2.71598E-7;625.677;735.228;356.883;147.515;85.587;443.137;6.82654;116.413;3.12114;15.7729;29.3336;78.9726;20.6424;38.4229;119.81;22.3266;4.89199;552.974;11.4115 2108.09;262.273;5.72313E-12;80.1461;1509.86;148.485;2.71599E-7;1106.02;1288.97;1021.06;658.494;240.486;2039.06;76.1794;496.915;90.6321;157.407;346.073;847.87;98.0534;163.044;1510.69;150.565;58.2504;2230.86;50.1592 2 24 2 362282;29397 PCK1_9439;CCL11_33230 757.86 757.86 323.3118477754875 454.9285 454.9285 138.65727582965147 1625.96 1625.96 855.4577838794855 529.244;986.476 356.883;552.974 1021.06;2230.86 24 315852;360243;24832;25671;291463;25682;299112;288583;363131;300795;313108;81687;291234;316273;293502;362376;156275;81919;24367;29243;84032;297594;114494;29657 TTK_32727;TOP2A_10059;THY1_33010;SMAD1_32578;PPIC_9541;PPARD_9536;POLE2_9520;PLOD3_9507;PIK3R4_9484;NS5ATP9_9367;MMS22L_33129;MMP9_32531;MKI67_9232;MCM3_9207;KIF22_8963;HERC6_8794;GGT7_33026;FUT1_8668;FGG_8639;F10_8585;COL3A1_8354;CDCA3_8260;CCNA2_8221;ARNTL_8086 234.74342084465016 99.14869999999999 304.3491399318256 142.10137626131683 33.5514 215.070216815026 561.9884416779836 201.765 667.451421864145 737.351;86.3883;5.72311E-12;21.9973;628.678;94.1074;2.71598E-7;882.629;955.628;292.216;126.653;728.316;21.9311;197.273;17.3097;39.6865;109.609;240.861;42.4612;104.19;212.603;56.6562;14.384;22.9134 446.625;26.6888;5.72311E-12;5.02186;389.239;37.7692;2.71598E-7;625.677;735.228;147.515;85.587;443.137;6.82654;116.413;3.12114;15.7729;29.3336;78.9726;20.6424;38.4229;119.81;22.3266;4.89199;11.4115 2108.09;262.273;5.72313E-12;80.1461;1509.86;148.485;2.71599E-7;1106.02;1288.97;658.494;240.486;2039.06;76.1794;496.915;90.6321;157.407;346.073;847.87;98.0534;163.044;1510.69;150.565;58.2504;50.1592 0 Exp 2,3(0.12);Exp 4,9(0.35);Exp 5,2(0.08);Hill,3(0.12);Linear,3(0.12);Poly 2,5(0.2);Power,1(0.04) 1.866014814522918 49.59729087352753 1.5018656253814697 3.442979335784912 0.4541693106357442 1.818645417690277 147.72390334428198 402.242412061226 79.7414804445202 252.58852188406473 365.9223147061946 921.7425006993137 DOWN 0.07692307692307693 0.9230769230769231 0.0 GO:0010605 6 negative regulation of macromolecule metabolic process 531 562 31 28 19 15 12 12 56 550 1929 0.23268 0.8513 0.45884 2.14 24832;295703;25682;25154;259241;81687;24426;25283;24854;24232;29657;29221 thy1;serping1;ppard;pgr;nr1d2;mmp9;gstp1;gclc;clu;c3;arntl;arg1 THY1_33010;SERPING1_32597;PPARD_9536;PGR_32824;NR1D2_9358;MMP9_32531;GSTP1_8762;GCLC_8699;CLU_32773;C3_8175;ARNTL_8086;ARG1_33267 272.36045000000047 112.90369999999999 5.72311E-12 338.328294879454 321.59389623246864 352.48057485715816 170.72489916666714 38.8425 5.72311E-12 254.1800184986362 196.68669446510137 259.4875422707099 736.1304416666671 272.847 5.72313E-12 898.225285525281 868.7251053880641 960.644796417621 5.72311E-12;32.3997;94.1074;283.618;29.1728;728.316;14.7631;131.7;935.649;234.759;22.9134;760.927 5.72311E-12;13.7308;37.7692;138.711;3.35457;443.137;9.42992;39.9158;808.484;129.148;11.4115;413.607 5.72313E-12;99.4885;148.485;1554.21;114.038;2039.06;25.7196;397.209;1071.05;694.216;50.1592;2639.93 2 10 2 259241;24426 NR1D2_9358;GSTP1_8762 21.96795 21.96795 10.18919658486379 6.392244999999999 6.392244999999999 4.295921183081692 69.8788 69.8788 62.45053954354597 29.1728;14.7631 3.35457;9.42992 114.038;25.7196 10 24832;295703;25682;25154;81687;25283;24854;24232;29657;29221 THY1_33010;SERPING1_32597;PPARD_9536;PGR_32824;MMP9_32531;GCLC_8699;CLU_32773;C3_8175;ARNTL_8086;ARG1_33267 322.43895000000055 183.22949999999997 350.9591930717842 203.59143000000057 84.5319 267.8829167884355 869.3807700000007 545.7125 931.2868175678537 5.72311E-12;32.3997;94.1074;283.618;728.316;131.7;935.649;234.759;22.9134;760.927 5.72311E-12;13.7308;37.7692;138.711;443.137;39.9158;808.484;129.148;11.4115;413.607 5.72313E-12;99.4885;148.485;1554.21;2039.06;397.209;1071.05;694.216;50.1592;2639.93 0 Exp 2,1(0.09);Exp 4,4(0.34);Exp 5,1(0.09);Hill,2(0.17);Linear,1(0.09);Poly 2,3(0.25) 1.9848344226392631 24.855833411216736 1.513624906539917 3.5281898975372314 0.6971398669335516 1.9010515809059143 80.933196519343 463.7877034806579 26.90901510591172 314.5407832274226 227.91164348353652 1244.3492398497974 DOWN 0.16666666666666666 0.8333333333333334 0.0 GO:0009889 5 regulation of biosynthetic process 634 681 39 36 24 22 16 16 52 665 1814 0.32625 0.76887 0.67691 2.35 360243;25671;25682;25154;362282;259241;316351;24426;25283;64191;24854;306575;113902;114494;24232;29657 top2a;smad1;ppard;pgr;pck1;nr1d2;npas2;gstp1;gclc;dhcr7;clu;ckap2;ces1d;ccna2;c3;arntl TOP2A_10059;SMAD1_32578;PPARD_9536;PGR_32824;PCK1_9439;NR1D2_9358;NPAS2_9350;GSTP1_8762;GCLC_8699;DHCR7_8466;CLU_32773;CKAP2_8324;CES1D_32914;CCNA2_8221;C3_8175;ARNTL_8086 164.04956875 59.31345 11.0684 248.21978844112255 141.58758588678486 220.40501942931823 103.33753562500002 20.97855 3.35457 208.65534328387974 81.29239328143353 190.69793296314677 380.97858125 131.2615 17.0564 467.5782126289836 332.01801360901817 375.5951780624304 86.3883;21.9973;94.1074;283.618;529.244;29.1728;21.0878;14.7631;131.7;161.702;935.649;32.2386;11.0684;14.384;234.759;22.9134 26.6888;5.02186;37.7692;138.711;356.883;3.35457;11.3305;9.42992;39.9158;50.9087;808.484;15.2683;4.18343;4.89199;129.148;11.4115 262.273;80.1461;148.485;1554.21;1021.06;114.038;43.5624;25.7196;397.209;481.517;1071.05;76.7052;17.0564;58.2504;694.216;50.1592 3 13 3 362282;259241;24426 PCK1_9439;NR1D2_9358;GSTP1_8762 191.05996666666667 29.1728 292.9645715179966 123.22249666666666 9.42992 202.3787305595517 386.93919999999997 114.038 550.9373164790346 529.244;29.1728;14.7631 356.883;3.35457;9.42992 1021.06;114.038;25.7196 13 360243;25671;25682;25154;316351;25283;64191;24854;306575;113902;114494;24232;29657 TOP2A_10059;SMAD1_32578;PPARD_9536;PGR_32824;NPAS2_9350;GCLC_8699;DHCR7_8466;CLU_32773;CKAP2_8324;CES1D_32914;CCNA2_8221;C3_8175;ARNTL_8086 157.8164 86.3883 249.97428274147526 98.74869846153845 26.6888 217.88404819160937 379.6030538461539 148.485 471.89738790957267 86.3883;21.9973;94.1074;283.618;21.0878;131.7;161.702;935.649;32.2386;11.0684;14.384;234.759;22.9134 26.6888;5.02186;37.7692;138.711;11.3305;39.9158;50.9087;808.484;15.2683;4.18343;4.89199;129.148;11.4115 262.273;80.1461;148.485;1554.21;43.5624;397.209;481.517;1071.05;76.7052;17.0564;58.2504;694.216;50.1592 0 Exp 4,9(0.57);Exp 5,2(0.13);Hill,1(0.07);Linear,1(0.07);Poly 2,3(0.19) 1.9902248176561266 33.163549184799194 1.5405861139297485 3.5281898975372314 0.6699615187422161 1.865848422050476 42.42187241384998 285.67726508615004 1.0964174158989408 205.5786538341011 151.8652570617981 610.0919054382018 DOWN 0.1875 0.8125 0.0 GO:0050866 6 negative regulation of cell activation 64 66 5 5 3 5 3 3 65 63 2416 0.90255 0.2574 0.2574 4.55 25283;24367;29221 gclc;fgg;arg1 GCLC_8699;FGG_8639;ARG1_33267 311.6960666666667 131.7 42.4612 391.5957283398446 262.62657449470646 359.9819189162909 158.05506666666668 39.9158 20.6424 221.52417240493946 128.79690867179983 204.2524321839689 1045.0641333333333 397.209 98.0534 1389.2700845215998 870.1030701636188 1277.374447789912 131.7;42.4612;760.927 39.9158;20.6424;413.607 397.209;98.0534;2639.93 0 3 0 3 25283;24367;29221 GCLC_8699;FGG_8639;ARG1_33267 311.6960666666667 131.7 391.5957283398446 158.05506666666668 39.9158 221.52417240493946 1045.0641333333333 397.209 1389.2700845215998 131.7;42.4612;760.927 39.9158;20.6424;413.607 397.209;98.0534;2639.93 0 Exp 2,1(0.34);Exp 4,1(0.34);Hill,1(0.34) 2.0345455001106436 6.305952191352844 1.513624906539917 2.8176381587982178 0.6612606455873788 1.9746891260147095 -131.4362157075463 754.8283490408796 -92.623132850535 408.73326618386835 -527.0429629269208 2617.1712295935877 DOWN 0.0 1.0 0.0 GO:1901615 4 organic hydroxy compound metabolic process 134 145 10 10 7 9 7 7 61 138 2341 0.96318 0.088756 0.10634 4.83 362282;25315;64191;312495;24296;113902;81639 pck1;ephx1;dhcr7;cyp26b1;cyp1a1;ces1d;alox15 PCK1_9439;EPHX1_8567;DHCR7_8466;CYP26B1_8418;CYP1A1_8415;CES1D_32914;ALOX15_8036 219.87785714285715 39.2381 11.0684 304.957153168156 203.51742813486183 290.84926198367816 124.4472557142857 18.9587 4.18343 182.2952828894359 102.8560337599021 166.84916333121407 617.0643428571428 81.6965 17.0564 975.0510687278692 634.2547064886971 997.2408540072647 529.244;39.2381;161.702;18.1872;12.8863;11.0684;766.819 356.883;18.9587;50.9087;10.0176;9.13136;4.18343;421.048 1021.06;81.6965;481.517;36.7271;19.3234;17.0564;2662.07 4 3 4 362282;25315;312495;24296 PCK1_9439;EPHX1_8567;CYP26B1_8418;CYP1A1_8415 149.8889 28.712650000000004 253.15933166440195 98.747665 14.488150000000001 172.1474529466824 289.70175 59.2118 488.27987178187396 529.244;39.2381;18.1872;12.8863 356.883;18.9587;10.0176;9.13136 1021.06;81.6965;36.7271;19.3234 3 64191;113902;81639 DHCR7_8466;CES1D_32914;ALOX15_8036 313.19646666666665 161.702 400.0033405148678 158.71337666666668 50.9087 228.38652250893577 1053.5478 481.517 1412.2459641145097 161.702;11.0684;766.819 50.9087;4.18343;421.048 481.517;17.0564;2662.07 0 Exp 2,1(0.15);Exp 4,4(0.58);Exp 5,1(0.15);Linear,1(0.15) 2.407084755706137 26.159300208091736 1.5021449327468872 15.48720932006836 5.186119943057944 1.7927976846694946 -6.037563444831591 445.7932777305458 -10.59897972328659 259.49349115185805 -105.2635973065303 1339.3922830208162 CONFLICT 0.5714285714285714 0.42857142857142855 0.0 GO:1901701 5 cellular response to oxygen-containing compound 359 378 29 29 20 22 17 17 51 361 2118 0.99187 0.017799 0.023568 4.5 116669;684352;25682;25154;362282;24314;81687;24426;25283;361921;312495;245920;84032;113902;114494;29221;170913 vwf;twf2;ppard;pgr;pck1;nqo1;mmp9;gstp1;gclc;ect2;cyp26b1;cxcl10;col3a1;ces1d;ccna2;arg1;abcb1a VWF_32396;TWF2_10109;PPARD_9536;PGR_32824;PCK1_9439;NQO1_33055;MMP9_32531;GSTP1_8762;GCLC_8699;ECT2_8523;CYP26B1_8418;CXCL10_8408;COL3A1_8354;CES1D_32914;CCNA2_8221;ARG1_33267;ABCB1A_7938 227.65888235294116 131.7 10.0162 270.8709041690369 192.56426133398662 265.80910859775014 128.0628923529412 39.9158 3.29405 161.16329692644706 104.84888217761987 157.38899604289801 791.3142411764705 299.165 17.0564 890.3592750324992 692.7951754198566 891.5671693013071 19.6764;138.399;94.1074;283.618;529.244;25.6813;728.316;14.7631;131.7;10.0162;18.1872;670.528;212.603;11.0684;14.384;760.927;206.982 4.11644;90.7363;37.7692;138.711;356.883;7.73944;443.137;9.42992;39.9158;3.29405;10.0176;374.802;119.81;4.18343;4.89199;413.607;118.025 94.078;299.165;148.485;1554.21;1021.06;86.1211;2039.06;25.7196;397.209;37.7305;36.7271;1955.3;1510.69;17.0564;58.2504;2639.93;1531.55 4 13 4 362282;24314;24426;312495 PCK1_9439;NQO1_33055;GSTP1_8762;CYP26B1_8418 146.96890000000002 21.93425 254.89084840528636 96.01749 9.723759999999999 173.91302115126362 292.40695 61.424099999999996 486.4783131619092 529.244;25.6813;14.7631;18.1872 356.883;7.73944;9.42992;10.0176 1021.06;86.1211;25.7196;36.7271 13 116669;684352;25682;25154;81687;25283;361921;245920;84032;113902;114494;29221;170913 VWF_32396;TWF2_10109;PPARD_9536;PGR_32824;MMP9_32531;GCLC_8699;ECT2_8523;CXCL10_8408;COL3A1_8354;CES1D_32914;CCNA2_8221;ARG1_33267;ABCB1A_7938 252.48656923076925 138.399 280.62012257538777 137.92301615384616 90.7363 163.1637719837821 944.8241769230771 397.209 943.0388788842677 19.6764;138.399;94.1074;283.618;728.316;131.7;10.0162;670.528;212.603;11.0684;14.384;760.927;206.982 4.11644;90.7363;37.7692;138.711;443.137;39.9158;3.29405;374.802;119.81;4.18343;4.89199;413.607;118.025 94.078;299.165;148.485;1554.21;2039.06;397.209;37.7305;1955.3;1510.69;17.0564;58.2504;2639.93;1531.55 0 Exp 2,2(0.12);Exp 4,4(0.24);Exp 5,2(0.12);Hill,3(0.18);Linear,2(0.12);Poly 2,4(0.24) 1.874032371212152 32.55167365074158 1.513624906539917 3.5281898975372314 0.46777275219502656 1.8538048267364502 98.89502802122496 356.4227366846574 51.450724085116164 204.6750606207662 368.0643083537397 1214.5641739992013 DOWN 0.23529411764705882 0.7647058823529411 0.0 GO:2001023 5 regulation of response to drug 39 43 4 3 2 2 2 2 66 41 2438 0.89457 0.3196 0.3196 4.65 29221;170913 arg1;abcb1a ARG1_33267;ABCB1A_7938 483.9545 483.9545 206.982 391.6982659043821 456.40324808706004 389.7555497341371 265.81600000000003 265.81600000000003 118.025 209.00803659668208 251.11480377486825 207.97141395177445 2085.74 2085.74 1531.55 783.7430141315464 2030.613125318823 779.8558633335869 760.927;206.982 413.607;118.025 2639.93;1531.55 0 2 0 2 29221;170913 ARG1_33267;ABCB1A_7938 483.9545 483.9545 391.6982659043821 265.81600000000003 265.81600000000003 209.00803659668208 2085.74 2085.74 783.7430141315464 760.927;206.982 413.607;118.025 2639.93;1531.55 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.6902459455699639 3.4011013507843018 1.513624906539917 1.8874764442443848 0.2643529574678474 1.7005506753921509 -58.911599999999964 1026.8206 -23.85435999999993 555.48636 999.5275999999999 3171.9523999999997 DOWN 0.0 1.0 0.0 GO:0055114 3 oxidation-reduction process 260 296 17 17 14 15 12 12 56 284 2195 0.95438 0.088773 0.1237 4.05 25682;288583;24314;84493;64191;312495;24296;116599;81639;26760;286921;252898 ppard;plod3;nqo1;fmo3;dhcr7;cyp26b1;cyp1a1;blvra;alox15;akr7a3;akr1b8;acox2 PPARD_9536;PLOD3_9507;NQO1_33055;FMO3_8654;DHCR7_8466;CYP26B1_8418;CYP1A1_8415;BLVRA_8151;ALOX15_8036;AKR7A3_8015;AKR1B8_8013;ACOX2_32902 344.5495416666667 288.8465 12.8863 326.9736977628391 295.67318193202146 290.0855582503026 219.13294166666665 169.47835 7.73944 223.10136832028385 183.71774013804978 197.53225833431395 769.6981333333333 596.8505 19.3234 871.0882382331449 688.3922262024505 820.9984961211688 94.1074;882.629;25.6813;418.073;161.702;18.1872;12.8863;415.991;766.819;52.7573;542.408;743.353 37.7692;625.677;7.73944;293.29;50.9087;10.0176;9.13136;288.048;421.048;12.408;441.021;432.537 148.485;1106.02;86.1211;712.184;481.517;36.7271;19.3234;720.942;2662.07;216.887;758.311;2287.79 5 7 5 24314;312495;24296;26760;286921 NQO1_33055;CYP26B1_8418;CYP1A1_8415;AKR7A3_8015;AKR1B8_8013 130.38402000000002 25.6813 230.83877921165455 96.06348 10.0176 192.84459606971828 223.47392 86.1211 308.833165485974 25.6813;18.1872;12.8863;52.7573;542.408 7.73944;10.0176;9.13136;12.408;441.021 86.1211;36.7271;19.3234;216.887;758.311 7 25682;288583;84493;64191;116599;81639;252898 PPARD_9536;PLOD3_9507;FMO3_8654;DHCR7_8466;BLVRA_8151;ALOX15_8036;ACOX2_32902 497.52491428571426 418.073 308.1501299731211 307.0397 293.29 211.71388868694936 1159.8582857142858 720.942 949.3727001335698 94.1074;882.629;418.073;161.702;415.991;766.819;743.353 37.7692;625.677;293.29;50.9087;288.048;421.048;432.537 148.485;1106.02;712.184;481.517;720.942;2662.07;2287.79 0 Exp 2,5(0.42);Exp 4,3(0.25);Exp 5,1(0.09);Hill,2(0.17);Poly 2,1(0.09) 2.105451203642989 34.94573521614075 1.5021449327468872 15.48720932006836 3.9660058023599047 1.785186231136322 159.54675629379014 529.5523270395431 92.90145931150273 345.3644240218306 276.8335650781467 1262.56270158852 CONFLICT 0.4166666666666667 0.5833333333333334 0.0 GO:0010212 5 response to ionizing radiation 75 76 9 9 8 6 5 5 63 71 2408 0.98542 0.050103 0.050103 6.58 116669;360243;361921;245920;24646 vwf;top2a;ect2;cxcl10;abcb1b VWF_32396;TOP2A_10059;ECT2_8523;CXCL10_8408;ABCB1B_7939 161.4806 20.7941 10.0162 286.1864321789644 59.672426984358154 145.39242525004175 83.43096800000001 8.25355 3.29405 163.15722177828468 25.400436193527714 81.75193191975276 481.31859999999995 94.078 37.7305 828.7331686745891 186.74676170225158 421.09196307640093 2.5 53.5912 19.6764;86.3883;10.0162;670.528;20.7941 4.11644;26.6888;3.29405;374.802;8.25355 94.078;262.273;37.7305;1955.3;57.2115 0 5 0 5 116669;360243;361921;245920;24646 VWF_32396;TOP2A_10059;ECT2_8523;CXCL10_8408;ABCB1B_7939 161.4806 20.7941 286.1864321789644 83.43096800000001 8.25355 163.15722177828468 481.31859999999995 94.078 828.7331686745891 19.6764;86.3883;10.0162;670.528;20.7941 4.11644;26.6888;3.29405;374.802;8.25355 94.078;262.273;37.7305;1955.3;57.2115 0 Exp 2,1(0.2);Exp 4,2(0.4);Hill,2(0.4) 2.3837559376208484 13.732268571853638 1.6358354091644287 6.191005229949951 1.9327735852936865 1.9603345394134521 -89.37286810339666 412.3340681033967 -59.582642455171424 226.44457845517144 -245.09805054315058 1207.7352505431506 DOWN 0.0 1.0 0.0 GO:0010811 7 positive regulation of cell-substrate adhesion 40 43 6 6 3 4 3 3 65 40 2439 0.97377 0.10543 0.10543 6.98 24832;81919;81639 thy1;fut1;alox15 THY1_33010;FUT1_8668;ALOX15_8036 335.8933333333352 240.861 5.72311E-12 392.14308992296594 352.064242847558 355.30019566145774 166.67353333333526 78.9726 5.72311E-12 223.80559612452134 167.2950795461489 209.49905438655293 1169.980000000002 847.87 5.72313E-12 1359.9523191274 1227.9322997620948 1230.786433408309 1.5 503.84 5.72311E-12;240.861;766.819 5.72311E-12;78.9726;421.048 5.72313E-12;847.87;2662.07 0 3 0 3 24832;81919;81639 THY1_33010;FUT1_8668;ALOX15_8036 335.8933333333352 240.861 392.14308992296594 166.67353333333526 78.9726 223.80559612452134 1169.980000000002 847.87 1359.9523191274 5.72311E-12;240.861;766.819 5.72311E-12;78.9726;421.048 5.72313E-12;847.87;2662.07 0 Exp 2,2(0.67);Hill,1(0.34) 1.971285228848998 6.102357506752014 1.5021449327468872 2.737008571624756 0.6349260171625842 1.863204002380371 -107.85834698130179 779.6450136479723 -86.58634015719346 419.93340682386395 -368.9509215651883 2708.9109215651924 DOWN 0.0 1.0 0.0 GO:0030258 5 lipid modification 64 70 5 5 5 4 4 4 64 66 2413 0.96292 0.11471 0.11471 5.71 25682;24296;81639;252898 ppard;cyp1a1;alox15;acox2 PPARD_9536;CYP1A1_8415;ALOX15_8036;ACOX2_32902 404.291425 418.73019999999997 12.8863 406.53048082455325 423.93389429464634 405.8117709965993 225.12139 229.4086 9.13136 233.21021127941 234.4577029673049 231.4611617079207 1279.4171000000001 1218.1375 19.3234 1389.8907025281903 1362.5755050410314 1411.6784776182867 2.5 755.086 94.1074;12.8863;766.819;743.353 37.7692;9.13136;421.048;432.537 148.485;19.3234;2662.07;2287.79 1 3 1 24296 CYP1A1_8415 12.8863 12.8863 9.13136 9.13136 19.3234 19.3234 12.8863 9.13136 19.3234 3 25682;81639;252898 PPARD_9536;ALOX15_8036;ACOX2_32902 534.7597999999999 743.353 381.7964988162148 297.11806666666666 421.048 224.67615641454555 1699.4483333333335 2287.79 1356.147788999537 94.1074;766.819;743.353 37.7692;421.048;432.537 148.485;2662.07;2287.79 0 Exp 2,2(0.5);Exp 4,1(0.25);Exp 5,1(0.25) 2.883184017766156 20.460219740867615 1.5021449327468872 15.48720932006836 6.917639162409731 1.735432744026184 5.891553791937838 802.6912962080621 -3.4246170538218337 453.6673970538218 -82.67578847762638 2641.5099884776264 DOWN 0.25 0.75 0.0 GO:0007165 4 signal transduction 714 752 44 43 28 25 17 17 51 735 1744 0.24672 0.83218 0.50052 2.26 688621;24832;25671;25682;25154;259241;309186;361921;312495;245920;84032;24854;170945;114494;29397;686019;24232 tslp;thy1;smad1;ppard;pgr;nr1d2;fermt3;ect2;cyp26b1;cxcl10;col3a1;clu;chrna2;ccna2;ccl11;casq1;c3 TSLP_32811;THY1_33010;SMAD1_32578;PPARD_9536;PGR_32824;NR1D2_9358;FERMT3_32542;ECT2_8523;CYP26B1_8418;CXCL10_8408;COL3A1_8354;CLU_32773;CHRNA2_32401;CCNA2_8221;CCL11_33230;CASQ1_32992;C3_8175 276.8485235294121 163.479 5.72311E-12 320.62123614819126 244.39734395561126 308.3272729762885 174.42921000000035 101.968 5.72311E-12 227.15993398941214 157.1379272843919 217.4326456345479 702.3607705882357 414.362 5.72313E-12 740.2108054015308 558.2628206382561 667.9543178289958 344.675;5.72311E-12;21.9973;94.1074;283.618;29.1728;539.113;10.0162;18.1872;670.528;212.603;935.649;163.479;14.384;986.476;147.66;234.759 244.2;5.72311E-12;5.02186;37.7692;138.711;3.35457;334.248;3.29405;10.0176;374.802;119.81;808.484;101.968;4.89199;552.974;96.6023;129.148 560.435;5.72313E-12;80.1461;148.485;1554.21;114.038;1187.86;37.7305;36.7271;1955.3;1510.69;1071.05;414.362;58.2504;2230.86;285.773;694.216 3 14 3 259241;312495;29397 NR1D2_9358;CYP26B1_8418;CCL11_33230 344.612 29.1728 555.8976674927139 188.78205666666668 10.0176 315.4170694237673 793.8750333333334 114.038 1245.0656969149072 29.1728;18.1872;986.476 3.35457;10.0176;552.974 114.038;36.7271;2230.86 14 688621;24832;25671;25682;25154;309186;361921;245920;84032;24854;170945;114494;686019;24232 TSLP_32811;THY1_33010;SMAD1_32578;PPARD_9536;PGR_32824;FERMT3_32542;ECT2_8523;CXCL10_8408;COL3A1_8354;CLU_32773;CHRNA2_32401;CCNA2_8221;CASQ1_32992;C3_8175 262.32777857142895 188.041 278.73279249425644 171.3536000000004 110.88900000000001 219.4222957773979 682.7505714285718 487.3985 658.4192599324562 344.675;5.72311E-12;21.9973;94.1074;283.618;539.113;10.0162;670.528;212.603;935.649;163.479;14.384;147.66;234.759 244.2;5.72311E-12;5.02186;37.7692;138.711;334.248;3.29405;374.802;119.81;808.484;101.968;4.89199;96.6023;129.148 560.435;5.72313E-12;80.1461;148.485;1554.21;1187.86;37.7305;1955.3;1510.69;1071.05;414.362;58.2504;285.773;694.216 0 Exp 2,3(0.18);Exp 4,5(0.3);Exp 5,1(0.06);Hill,1(0.06);Poly 2,6(0.36);Power,1(0.06) 1.7863949834785013 30.60307240486145 1.5405861139297485 2.327066659927368 0.2361277820926875 1.6932154893875122 124.43486258753052 429.2621844712938 66.44423191626525 282.4141880837354 350.4868895086885 1054.2346516677826 DOWN 0.17647058823529413 0.8235294117647058 0.0 GO:0007276 4 gamete generation 71 79 8 7 5 5 4 4 64 75 2404 0.94248 0.15799 0.15799 5.06 25671;312495;24854;29657 smad1;cyp26b1;clu;arntl SMAD1_32578;CYP26B1_8418;CLU_32773;ARNTL_8086 249.686725 22.45535 18.1872 457.31276240912246 301.2465620847471 488.33187127700677 208.73374 10.71455 5.02186 399.8429171221782 255.35002085693995 425.77601704768244 309.5206 65.15265 36.7271 508.0106028312204 360.1731299060996 547.3765438327608 2.5 479.2812 21.9973;18.1872;935.649;22.9134 5.02186;10.0176;808.484;11.4115 80.1461;36.7271;1071.05;50.1592 1 3 1 312495 CYP26B1_8418 18.1872 18.1872 10.0176 10.0176 36.7271 36.7271 18.1872 10.0176 36.7271 3 25671;24854;29657 SMAD1_32578;CLU_32773;ARNTL_8086 326.8532333333333 22.9134 527.2327986224333 274.97245333333336 11.4115 462.04559806887744 400.45176666666663 80.1461 580.9486177410557 21.9973;935.649;22.9134 5.02186;808.484;11.4115 80.1461;1071.05;50.1592 0 Exp 4,3(0.75);Poly 2,1(0.25) 2.086355858099505 8.781388759613037 1.5548590421676636 3.442979335784912 0.862162951756311 1.8917751908302307 -198.47978216094 697.85323216094 -183.1123187797347 600.5797987797347 -188.32979077459606 807.3709907745961 DOWN 0.25 0.75 0.0 GO:0044238 3 primary metabolic process 1157 1278 75 75 52 52 40 40 28 1238 1241 0.94194 0.09278 0.17612 3.13 286989;315852;360243;24832;25671;291463;25682;299112;288583;363131;25154;362282;300795;313108;81687;291234;316273;293502;362376;24426;156275;25283;81919;24367;29243;25315;64191;312495;24296;84032;113902;297594;114494;29397;24232;25612;29657;29221;81639;252898 ugt2b7;ttk;top2a;thy1;smad1;ppic;ppard;pole2;plod3;pik3r4;pgr;pck1;pclaf;mms22l;mmp9;mki67;mcm3;kif22;herc6;gstp1;ggt7;gclc;fut1;fgg;f10;ephx1;dhcr7;cyp26b1;cyp1a1;col3a1;ces1d;cdca3;ccna2;ccl11;c3;asns;arntl;arg1;alox15;acox2 UGT2B7_33032;TTK_32727;TOP2A_10059;THY1_33010;SMAD1_32578;PPIC_9541;PPARD_9536;POLE2_9520;PLOD3_9507;PIK3R4_9484;PGR_32824;PCK1_9439;NS5ATP9_9367;MMS22L_33129;MMP9_32531;MKI67_9232;MCM3_9207;KIF22_8963;HERC6_8794;GSTP1_8762;GGT7_33026;GCLC_8699;FUT1_8668;FGG_8639;F10_8585;EPHX1_8567;DHCR7_8466;CYP26B1_8418;CYP1A1_8415;COL3A1_8354;CES1D_32914;CDCA3_8260;CCNA2_8221;CCL11_33230;C3_8175;ASNS_8091;ARNTL_8086;ARG1_33267;ALOX15_8036;ACOX2_32902 263.8610200067901 118.131 5.72311E-12 314.60377105581523 222.95854336229837 288.6146346315142 153.1555860067901 39.169349999999994 5.72311E-12 204.60638353712866 121.56563472454484 178.42264622546293 706.3099650067901 304.173 5.72313E-12 828.1631735798633 630.2162441818843 815.0672225000712 34.7126;737.351;86.3883;5.72311E-12;21.9973;628.678;94.1074;2.71598E-7;882.629;955.628;283.618;529.244;292.216;126.653;728.316;21.9311;197.273;17.3097;39.6865;14.7631;109.609;131.7;240.861;42.4612;104.19;39.2381;161.702;18.1872;12.8863;212.603;11.0684;56.6562;14.384;986.476;234.759;191.145;22.9134;760.927;766.819;743.353 14.7729;446.625;26.6888;5.72311E-12;5.02186;389.239;37.7692;2.71598E-7;625.677;735.228;138.711;356.883;147.515;85.587;443.137;6.82654;116.413;3.12114;15.7729;9.42992;29.3336;39.9158;78.9726;20.6424;38.4229;18.9587;50.9087;10.0176;9.13136;119.81;4.18343;22.3266;4.89199;552.974;129.148;113.564;11.4115;413.607;421.048;432.537 105.024;2108.09;262.273;5.72313E-12;80.1461;1509.86;148.485;2.71599E-7;1106.02;1288.97;1554.21;1021.06;658.494;240.486;2039.06;76.1794;496.915;90.6321;157.407;25.7196;346.073;397.209;847.87;98.0534;163.044;81.6965;481.517;36.7271;19.3234;1510.69;17.0564;150.565;58.2504;2230.86;694.216;510.267;50.1592;2639.93;2662.07;2287.79 7 33 7 286989;362282;24426;25315;312495;24296;29397 UGT2B7_33032;PCK1_9439;GSTP1_8762;EPHX1_8567;CYP26B1_8418;CYP1A1_8415;CCL11_33230 233.64390000000003 34.7126 381.7868469982171 138.88106857142859 14.7729 223.22648820899485 502.91580000000005 81.6965 843.4964809397942 34.7126;529.244;14.7631;39.2381;18.1872;12.8863;986.476 14.7729;356.883;9.42992;18.9587;10.0176;9.13136;552.974 105.024;1021.06;25.7196;81.6965;36.7271;19.3234;2230.86 33 315852;360243;24832;25671;291463;25682;299112;288583;363131;25154;300795;313108;81687;291234;316273;293502;362376;156275;25283;81919;24367;29243;64191;84032;113902;297594;114494;24232;25612;29657;29221;81639;252898 TTK_32727;TOP2A_10059;THY1_33010;SMAD1_32578;PPIC_9541;PPARD_9536;POLE2_9520;PLOD3_9507;PIK3R4_9484;PGR_32824;NS5ATP9_9367;MMS22L_33129;MMP9_32531;MKI67_9232;MCM3_9207;KIF22_8963;HERC6_8794;GGT7_33026;GCLC_8699;FUT1_8668;FGG_8639;F10_8585;DHCR7_8466;COL3A1_8354;CES1D_32914;CDCA3_8260;CCNA2_8221;C3_8175;ASNS_8091;ARNTL_8086;ARG1_33267;ALOX15_8036;ACOX2_32902 270.2707121294425 131.7 305.047706363844 156.18351394762433 50.9087 204.02036023898597 749.4541818264122 397.209 831.5720481890405 737.351;86.3883;5.72311E-12;21.9973;628.678;94.1074;2.71598E-7;882.629;955.628;283.618;292.216;126.653;728.316;21.9311;197.273;17.3097;39.6865;109.609;131.7;240.861;42.4612;104.19;161.702;212.603;11.0684;56.6562;14.384;234.759;191.145;22.9134;760.927;766.819;743.353 446.625;26.6888;5.72311E-12;5.02186;389.239;37.7692;2.71598E-7;625.677;735.228;138.711;147.515;85.587;443.137;6.82654;116.413;3.12114;15.7729;29.3336;39.9158;78.9726;20.6424;38.4229;50.9087;119.81;4.18343;22.3266;4.89199;129.148;113.564;11.4115;413.607;421.048;432.537 2108.09;262.273;5.72313E-12;80.1461;1509.86;148.485;2.71599E-7;1106.02;1288.97;1554.21;658.494;240.486;2039.06;76.1794;496.915;90.6321;157.407;346.073;397.209;847.87;98.0534;163.044;481.517;1510.69;17.0564;150.565;58.2504;694.216;510.267;50.1592;2639.93;2662.07;2287.79 0 Exp 2,6(0.15);Exp 4,15(0.38);Exp 5,3(0.08);Hill,4(0.1);Linear,3(0.08);Poly 2,8(0.2);Power,1(0.03) 2.009339832887394 93.51718974113464 1.5018656253814697 15.48720932006836 2.2750230124977295 1.7990894317626953 166.36430125936604 361.3577387542143 89.74741081963417 216.56376119394594 449.65953853378664 962.9603914797935 DOWN 0.175 0.825 0.0 GO:2001037 9 positive regulation of tongue muscle cell differentiation 1 1 1 1 1 1 1 1 67 0 2479 1.0 0.026698 0.026698 100.0 312495 cyp26b1 CYP26B1_8418 18.1872 18.1872 18.1872 18.1872 10.0176 10.0176 10.0176 10.0176 36.7271 36.7271 36.7271 36.7271 0.0 18.1872 0.0 18.1872 18.1872 10.0176 36.7271 1 0 1 312495 CYP26B1_8418 18.1872 18.1872 10.0176 10.0176 36.7271 36.7271 18.1872 10.0176 36.7271 0 0 Exp 4,1(1) 2.090334892272949 2.090334892272949 2.090334892272949 2.090334892272949 0.0 2.090334892272949 18.1872 18.1872 10.0176 10.0176 36.7271 36.7271 UP 1.0 0.0 0.0 GO:0006631 6 fatty acid metabolic process 129 145 11 11 10 9 9 9 59 136 2343 0.99561 0.013491 0.013491 6.21 25682;362282;24426;25315;24296;113902;24232;81639;252898 ppard;pck1;gstp1;ephx1;cyp1a1;ces1d;c3;alox15;acox2 PPARD_9536;PCK1_9439;GSTP1_8762;EPHX1_8567;CYP1A1_8415;CES1D_32914;C3_8175;ALOX15_8036;ACOX2_32902 271.8042555555555 94.1074 11.0684 320.50749357430044 284.1801294447821 340.228203537932 157.67651222222221 37.7692 4.18343 189.2858832211443 159.5162470072575 195.0730911086818 773.0463222222222 148.485 17.0564 1030.578813475357 868.5149463480033 1148.9563504138716 6.5 636.2985 94.1074;529.244;14.7631;39.2381;12.8863;11.0684;234.759;766.819;743.353 37.7692;356.883;9.42992;18.9587;9.13136;4.18343;129.148;421.048;432.537 148.485;1021.06;25.7196;81.6965;19.3234;17.0564;694.216;2662.07;2287.79 4 5 4 362282;24426;25315;24296 PCK1_9439;GSTP1_8762;EPHX1_8567;CYP1A1_8415 149.03287500000002 27.000600000000002 253.75818840899663 98.60074499999999 14.19431 172.24864340358474 286.94987499999996 53.70805 490.2080545625185 529.244;14.7631;39.2381;12.8863 356.883;9.42992;18.9587;9.13136 1021.06;25.7196;81.6965;19.3234 5 25682;113902;24232;81639;252898 PPARD_9536;CES1D_32914;C3_8175;ALOX15_8036;ACOX2_32902 370.02136 234.759 360.58859084248337 204.93712599999998 129.148 207.6636499646156 1161.92348 694.216 1232.329447914133 94.1074;11.0684;234.759;766.819;743.353 37.7692;4.18343;129.148;421.048;432.537 148.485;17.0564;694.216;2662.07;2287.79 0 Exp 2,2(0.23);Exp 4,3(0.34);Exp 5,2(0.23);Linear,1(0.12);Poly 2,1(0.12) 2.3301603124537174 30.82198429107666 1.5021449327468872 15.48720932006836 4.568119421898556 1.6269687414169312 62.40602642034585 481.20248469076523 34.009735184407916 281.3432892600365 99.73483075165564 1446.3578136927888 CONFLICT 0.4444444444444444 0.5555555555555556 0.0 GO:0048609 3 multicellular organismal reproductive process 128 145 15 14 10 10 7 7 61 138 2341 0.96318 0.088756 0.10634 4.83 25671;25154;312495;24296;24854;29657;29221 smad1;pgr;cyp26b1;cyp1a1;clu;arntl;arg1 SMAD1_32578;PGR_32824;CYP26B1_8418;CYP1A1_8415;CLU_32773;ARNTL_8086;ARG1_33267 293.73974285714286 22.9134 12.8863 394.21073061581274 361.1778503182566 419.6580475486153 199.4834742857143 11.4115 5.02186 307.06716151618053 244.003351687392 320.5375654793354 778.7922571428571 80.1461 19.3234 1024.450030451474 940.9450490958142 1134.3915796983395 21.9973;283.618;18.1872;12.8863;935.649;22.9134;760.927 5.02186;138.711;10.0176;9.13136;808.484;11.4115;413.607 80.1461;1554.21;36.7271;19.3234;1071.05;50.1592;2639.93 2 5 2 312495;24296 CYP26B1_8418;CYP1A1_8415 15.536750000000001 15.536750000000001 3.7483023363917627 9.574480000000001 9.574480000000001 0.6266663137587598 28.02525 28.02525 12.306274287736318 18.1872;12.8863 10.0176;9.13136 36.7271;19.3234 5 25671;25154;24854;29657;29221 SMAD1_32578;PGR_32824;CLU_32773;ARNTL_8086;ARG1_33267 405.02094 283.618 422.99149411318905 275.44707200000005 138.711 340.8657595994513 1079.09906 1071.05 1086.1183945276673 21.9973;283.618;935.649;22.9134;760.927 5.02186;138.711;808.484;11.4115;413.607 80.1461;1554.21;1071.05;50.1592;2639.93 0 Exp 2,1(0.15);Exp 4,4(0.58);Poly 2,2(0.29) 2.5411657518546575 27.322809100151062 1.513624906539917 15.48720932006836 5.153935472940769 1.6932154893875122 1.70434679563823 585.7751389186475 -27.99506236085446 426.9620109322831 19.86905401045601 1537.7154602752582 DOWN 0.2857142857142857 0.7142857142857143 0.0 GO:0012501 4 programmed cell death 149 161 6 6 4 3 3 3 65 158 2321 0.3667 0.8156 0.79843 1.86 25682;312495;246142 ppard;cyp26b1;bmf PPARD_9536;CYP26B1_8418;BMF_8152 77.23186666666668 94.1074 18.1872 52.67490907987721 76.75145242100477 55.68056879029438 43.20513333333333 37.7692 10.0176 36.212801032968066 45.70973098431461 39.01574654464296 135.09903333333332 148.485 36.7271 92.40897115974909 137.03763803137076 99.00873878516158 94.1074;18.1872;119.401 37.7692;10.0176;81.8286 148.485;36.7271;220.085 1 2 1 312495 CYP26B1_8418 18.1872 18.1872 10.0176 10.0176 36.7271 36.7271 18.1872 10.0176 36.7271 2 25682;246142 PPARD_9536;BMF_8152 106.7542 106.7542 17.88527608061999 59.798899999999996 59.798899999999996 31.154700515010575 184.28500000000003 184.28500000000003 50.62884553295679 94.1074;119.401 37.7692;81.8286 148.485;220.085 0 Exp 4,1(0.34);Exp 5,1(0.34);Poly 2,1(0.34) 1.8661062854292059 5.632619857788086 1.6033858060836792 2.090334892272949 0.24920587339135084 1.9388991594314575 17.624595710526542 136.8391376228068 2.2264913013241667 84.18377536534251 30.528438359083083 239.66962830758362 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0070664 7 negative regulation of leukocyte proliferation 29 30 2 2 2 2 2 2 66 28 2451 0.95581 0.19005 0.19005 6.67 24426;29221 gstp1;arg1 GSTP1_8762;ARG1_33267 387.84505 387.84505 14.7631 527.617553566601 481.0935241680435 510.8715366530693 211.51846 211.51846 9.42992 285.7963540681777 262.02867096530565 276.72548342200764 1332.8247999999999 1332.8247999999999 25.7196 1848.525901288397 1659.523975548737 1789.8556660037232 0.5 387.84505 14.7631;760.927 9.42992;413.607 25.7196;2639.93 1 1 1 24426 GSTP1_8762 14.7631 14.7631 9.42992 9.42992 25.7196 25.7196 14.7631 9.42992 25.7196 1 29221 ARG1_33267 760.927 760.927 413.607 413.607 2639.93 2639.93 760.927 413.607 2639.93 0 Exp 2,1(0.5);Exp 4,1(0.5) 2.3109210509913294 5.041814804077148 1.513624906539917 3.5281898975372314 1.4245125662752172 2.520907402038574 -343.3955719999999 1119.085672 -184.57507839999997 607.6119984000001 -1229.101392 3894.7509919999998 CONFLICT 0.5 0.5 0.0 GO:0003006 3 developmental process involved in reproduction 220 234 20 17 11 14 8 8 60 226 2253 0.83315 0.28359 0.39873 3.42 116669;25682;25154;312495;24854;29657;24646;170913 vwf;ppard;pgr;cyp26b1;clu;arntl;abcb1b;abcb1a VWF_32396;PPARD_9536;PGR_32824;CYP26B1_8418;CLU_32773;ARNTL_8086;ABCB1B_7939;ABCB1A_7938 200.24093749999997 58.5104 18.1872 313.614836846523 151.574222764115 278.2177663870236 142.09853625 24.59035 4.11644 274.3884685320081 106.04583717030367 241.22133934129468 567.93385 121.28150000000001 36.7271 693.4394413309561 464.1165364646114 655.7185299550307 19.6764;94.1074;283.618;18.1872;935.649;22.9134;20.7941;206.982 4.11644;37.7692;138.711;10.0176;808.484;11.4115;8.25355;118.025 94.078;148.485;1554.21;36.7271;1071.05;50.1592;57.2115;1531.55 1 7 1 312495 CYP26B1_8418 18.1872 18.1872 10.0176 10.0176 36.7271 36.7271 18.1872 10.0176 36.7271 7 116669;25682;25154;24854;29657;24646;170913 VWF_32396;PPARD_9536;PGR_32824;CLU_32773;ARNTL_8086;ABCB1B_7939;ABCB1A_7938 226.24861428571427 94.1074 329.2925505614647 160.96724142857144 37.7692 290.7133902651941 643.8205285714286 148.485 712.2166903894645 19.6764;94.1074;283.618;935.649;22.9134;20.7941;206.982 4.11644;37.7692;138.711;808.484;11.4115;8.25355;118.025 94.078;148.485;1554.21;1071.05;50.1592;57.2115;1531.55 0 Exp 4,2(0.25);Exp 5,1(0.13);Hill,2(0.25);Poly 2,3(0.38) 2.3121574151511814 20.737428784370422 1.5405861139297485 6.191005229949951 1.5713238601629367 2.0146170258522034 -17.08305675859137 417.56493175859134 -48.04297159280699 332.240044092807 87.4048333188166 1048.4628666811836 DOWN 0.125 0.875 0.0 GO:0050731 10 positive regulation of peptidyl-tyrosine phosphorylation 66 72 6 5 3 2 2 2 66 70 2409 0.69844 0.57972 0.71828 2.78 688621;24832 tslp;thy1 TSLP_32811;THY1_33010 172.33750000000288 172.33750000000288 5.72311E-12 243.72202980546922 224.16725352112877 232.4387685227589 122.10000000000285 122.10000000000285 5.72311E-12 172.67547596575085 158.82104391052394 164.68135859362394 280.2175000000028 280.2175000000028 5.72313E-12 396.28738891427867 364.4916942833491 377.9410204890207 344.675;5.72311E-12 244.2;5.72311E-12 560.435;5.72313E-12 0 2 0 2 688621;24832 TSLP_32811;THY1_33010 172.33750000000288 172.33750000000288 243.72202980546922 122.10000000000285 122.10000000000285 172.67547596575085 280.2175000000028 280.2175000000028 396.28738891427867 344.675;5.72311E-12 244.2;5.72311E-12 560.435;5.72313E-12 0 Exp 2,1(0.5);Hill,1(0.5) 1.7723165163775398 3.5490665435791016 1.6858625411987305 1.863204002380371 0.12539934978706896 1.7745332717895508 -165.4439999999915 510.11899999999724 -117.2159999999915 361.4159999999972 -269.00879999999154 829.4437999999972 DOWN 0.0 1.0 0.0 GO:0042445 4 hormone metabolic process 53 64 7 7 4 5 4 4 64 60 2419 0.97361 0.089325 0.089325 6.25 286989;64191;312495;24296 ugt2b7;dhcr7;cyp26b1;cyp1a1 UGT2B7_33032;DHCR7_8466;CYP26B1_8418;CYP1A1_8415 56.872025 26.4499 12.8863 70.5020648962083 74.31030742674906 77.49479237360978 21.20764 12.39525 9.13136 19.955052641968482 26.103571419573456 21.985200100152998 160.647875 70.87555 19.3234 217.08675420893184 214.65864812437712 237.64467305114462 2.5 98.2073 34.7126;161.702;18.1872;12.8863 14.7729;50.9087;10.0176;9.13136 105.024;481.517;36.7271;19.3234 3 1 3 286989;312495;24296 UGT2B7_33032;CYP26B1_8418;CYP1A1_8415 21.928700000000003 18.1872 11.384022119180901 11.307286666666668 10.0176 3.0338444532528897 53.6915 36.7271 45.29891125192746 34.7126;18.1872;12.8863 14.7729;10.0176;9.13136 105.024;36.7271;19.3234 1 64191 DHCR7_8466 161.702 161.702 50.9087 50.9087 481.517 481.517 161.702 50.9087 481.517 0 Exp 4,4(1) 4.30733476331558 25.301154255867004 1.7927976846694946 15.48720932006836 6.392044784724981 4.010573625564575 -12.219998598284128 125.96404859828414 1.6516884108708894 40.76359158912911 -52.09714412475313 373.3928941247531 UP 0.75 0.25 0.0 GO:0048878 5 chemical homeostasis 274 291 22 21 11 14 9 9 59 282 2197 0.75648 0.37238 0.56544 3.09 24832;362282;259241;25283;312495;245920;113902;686019;252898 thy1;pck1;nr1d2;gclc;cyp26b1;cxcl10;ces1d;casq1;acox2 THY1_33010;PCK1_9439;NR1D2_9358;GCLC_8699;CYP26B1_8418;CXCL10_8408;CES1D_32914;CASQ1_32992;ACOX2_32902 253.43482222222286 131.7 5.72311E-12 305.0964012566259 167.80256898547833 232.9404773648075 146.47730000000064 39.9158 5.72311E-12 184.6903687647004 91.35341061033866 140.6467702498335 679.4392777777783 285.773 5.72313E-12 880.2762898179092 451.2901091804615 690.7098807170788 5.72311E-12;529.244;29.1728;131.7;18.1872;670.528;11.0684;147.66;743.353 5.72311E-12;356.883;3.35457;39.9158;10.0176;374.802;4.18343;96.6023;432.537 5.72313E-12;1021.06;114.038;397.209;36.7271;1955.3;17.0564;285.773;2287.79 3 6 3 362282;259241;312495 PCK1_9439;NR1D2_9358;CYP26B1_8418 192.20133333333334 29.1728 291.93918924524905 123.41838999999999 10.0176 202.21372872293884 390.60836666666665 114.038 547.3538072345923 529.244;29.1728;18.1872 356.883;3.35457;10.0176 1021.06;114.038;36.7271 6 24832;25283;245920;113902;686019;252898 THY1_33010;GCLC_8699;CXCL10_8408;CES1D_32914;CASQ1_32992;ACOX2_32902 284.0515666666676 139.68 333.86841758897475 158.00675500000094 68.25905 194.27339723220624 823.8547333333344 341.491 1022.2028724550253 5.72311E-12;131.7;670.528;11.0684;147.66;743.353 5.72311E-12;39.9158;374.802;4.18343;96.6023;432.537 5.72313E-12;397.209;1955.3;17.0564;285.773;2287.79 0 Exp 2,2(0.23);Exp 4,2(0.23);Exp 5,1(0.12);Hill,2(0.23);Linear,1(0.12);Poly 2,1(0.12) 1.8781693582914318 17.061823964118958 1.5319663286209106 2.327066659927368 0.27398267460098813 1.863204002380371 54.10517340122732 452.76447104321846 25.812925740396395 267.1416742596049 104.32543509674451 1254.5531204588124 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0051187 5 cofactor catabolic process 18 20 5 5 3 3 2 2 66 18 2461 0.98501 0.098041 0.098041 10.0 156275;116599 ggt7;blvra GGT7_33026;BLVRA_8151 262.8 262.8 109.609 216.64478983349673 229.36874553205445 211.42295857214498 158.6908 158.6908 29.3336 182.93870663060892 130.46085522216757 178.52929961034704 533.5074999999999 533.5074999999999 346.073 265.07241195662016 492.60320101656004 258.68332035492125 0.0 109.609 1.0 415.991 109.609;415.991 29.3336;288.048 346.073;720.942 0 2 0 2 156275;116599 GGT7_33026;BLVRA_8151 262.8 262.8 216.64478983349673 158.6908 158.6908 182.93870663060892 533.5074999999999 533.5074999999999 265.07241195662016 109.609;415.991 29.3336;288.048 346.073;720.942 0 Exp 2,1(0.5);Exp 4,1(0.5) 1.740326355439393 3.499440312385559 1.5686544179916382 1.930785894393921 0.2560656226451503 1.7497201561927795 -37.45435999999995 563.05436 -94.849312 412.230912 166.13587999999993 900.87912 DOWN 0.0 1.0 0.0 GO:0070555 6 response to interleukin-1 63 66 9 9 6 7 5 5 63 61 2418 0.99253 0.029701 0.029701 7.58 362282;81687;25283;24367;29397 pck1;mmp9;gclc;fgg;ccl11 PCK1_9439;MMP9_32531;GCLC_8699;FGG_8639;CCL11_33230 483.63944000000004 529.244 42.4612 397.8977914791285 415.43341539876866 415.31358297985105 282.71044 356.883 20.6424 240.7849333307796 232.64138734696766 252.52049578273602 1157.24848 1021.06 98.0534 955.0307303198427 1056.0705469535064 1013.2909139261864 2.5 628.78 529.244;728.316;131.7;42.4612;986.476 356.883;443.137;39.9158;20.6424;552.974 1021.06;2039.06;397.209;98.0534;2230.86 2 3 2 362282;29397 PCK1_9439;CCL11_33230 757.86 757.86 323.3118477754875 454.9285 454.9285 138.65727582965147 1625.96 1625.96 855.4577838794855 529.244;986.476 356.883;552.974 1021.06;2230.86 3 81687;25283;24367 MMP9_32531;GCLC_8699;FGG_8639 300.82573333333335 131.7 372.89654990012093 167.8984 39.9158 238.55833916331662 844.7741333333333 397.209 1045.0418971231024 728.316;131.7;42.4612 443.137;39.9158;20.6424 2039.06;397.209;98.0534 0 Exp 4,1(0.2);Hill,1(0.2);Linear,2(0.4);Power,1(0.2) 2.052692195618967 10.436565160751343 1.611412525177002 2.8176381587982178 0.4430109192846139 1.9814788103103638 134.86664814100783 832.4122318589921 71.65314027693177 493.76773972306825 320.12713563019656 1994.3698243698034 DOWN 0.4 0.6 0.0 GO:0009892 5 negative regulation of metabolic process 589 626 34 31 21 17 13 13 55 613 1866 0.1804 0.88791 0.32079 2.08 24832;295703;25682;25154;259241;81687;24426;25283;24854;24232;246142;29657;29221 thy1;serping1;ppard;pgr;nr1d2;mmp9;gstp1;gclc;clu;c3;bmf;arntl;arg1 THY1_33010;SERPING1_32597;PPARD_9536;PGR_32824;NR1D2_9358;MMP9_32531;GSTP1_8762;GCLC_8699;CLU_32773;C3_8175;BMF_8152;ARNTL_8086;ARG1_33267 260.5943384615389 119.401 5.72311E-12 326.6908887709154 295.45356906851015 335.282412718908 163.88672230769274 39.9158 5.72311E-12 244.6046066671267 181.83736878308238 244.60227236925815 696.434638461539 220.085 5.72313E-12 871.8138829806862 784.8662513805826 921.5523595219627 5.72311E-12;32.3997;94.1074;283.618;29.1728;728.316;14.7631;131.7;935.649;234.759;119.401;22.9134;760.927 5.72311E-12;13.7308;37.7692;138.711;3.35457;443.137;9.42992;39.9158;808.484;129.148;81.8286;11.4115;413.607 5.72313E-12;99.4885;148.485;1554.21;114.038;2039.06;25.7196;397.209;1071.05;694.216;220.085;50.1592;2639.93 2 11 2 259241;24426 NR1D2_9358;GSTP1_8762 21.96795 21.96795 10.18919658486379 6.392244999999999 6.392244999999999 4.295921183081692 69.8788 69.8788 62.45053954354597 29.1728;14.7631 3.35457;9.42992 114.038;25.7196 11 24832;295703;25682;25154;81687;25283;24854;24232;246142;29657;29221 THY1_33010;SERPING1_32597;PPARD_9536;PGR_32824;MMP9_32531;GCLC_8699;CLU_32773;C3_8175;BMF_8152;ARNTL_8086;ARG1_33267 303.98095454545506 131.7 338.5303431594255 192.52208181818233 81.8286 256.7741547688268 810.3538818181823 397.209 904.9262576203724 5.72311E-12;32.3997;94.1074;283.618;728.316;131.7;935.649;234.759;119.401;22.9134;760.927 5.72311E-12;13.7308;37.7692;138.711;443.137;39.9158;808.484;129.148;81.8286;11.4115;413.607 5.72313E-12;99.4885;148.485;1554.21;2039.06;397.209;1071.05;694.216;220.085;50.1592;2639.93 0 Exp 2,1(0.08);Exp 4,4(0.31);Exp 5,1(0.08);Hill,2(0.16);Linear,1(0.08);Poly 2,4(0.31) 1.9525158668542468 26.459219217300415 1.513624906539917 3.5281898975372314 0.6799609429938512 1.863204002380371 83.003148357442 438.18552856563576 30.91814345815959 296.8553011572259 222.51121313949858 1170.3580637835792 DOWN 0.15384615384615385 0.8461538461538461 0.0 GO:0070301 6 cellular response to hydrogen peroxide 41 45 3 3 3 3 3 3 65 42 2437 0.96957 0.11684 0.11684 6.67 24314;361921;29221 nqo1;ect2;arg1 NQO1_33055;ECT2_8523;ARG1_33267 265.5415 25.6813 10.0162 429.08792111546325 225.78501198565098 408.1778576666666 141.54683 7.73944 3.29405 235.6215025170341 119.6248393901667 224.20135654435094 921.2605333333332 86.1211 37.7305 1488.6080626818139 783.204723000633 1416.1530992809212 1.5 393.30415 25.6813;10.0162;760.927 7.73944;3.29405;413.607 86.1211;37.7305;2639.93 1 2 1 24314 NQO1_33055 25.6813 25.6813 7.73944 7.73944 86.1211 86.1211 25.6813 7.73944 86.1211 2 361921;29221 ECT2_8523;ARG1_33267 385.4716 385.4716 530.9741187462154 208.45052500000003 208.45052500000003 290.1350693536568 1338.83025 1338.83025 1840.0329124502432 10.0162;760.927 3.29405;413.607 37.7305;2639.93 0 Exp 2,1(0.34);Exp 4,1(0.34);Hill,1(0.34) 1.7522296310825403 5.322237491607666 1.513624906539917 2.1727771759033203 0.3506478722848471 1.6358354091644287 -220.017192453578 751.1001924535781 -125.08400029394448 408.1776602939445 -763.2580674527641 2605.7791341194306 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0050863 7 regulation of T cell activation 94 99 6 6 4 4 3 3 65 96 2383 0.7294 0.49758 0.74653 3.03 24832;312495;29221 thy1;cyp26b1;arg1 THY1_33010;CYP26B1_8418;ARG1_33267 259.70473333333524 18.1872 5.72311E-12 434.1664588758693 274.6209744105973 437.834539864156 141.2082000000019 10.0176 5.72311E-12 235.95744904223557 149.32819899337875 237.9386230693286 892.2190333333351 36.7271 5.72313E-12 1513.673490956289 941.5331840264911 1528.9197361926351 5.72311E-12;18.1872;760.927 5.72311E-12;10.0176;413.607 5.72313E-12;36.7271;2639.93 1 2 1 312495 CYP26B1_8418 18.1872 18.1872 10.0176 10.0176 36.7271 36.7271 18.1872 10.0176 36.7271 2 24832;29221 THY1_33010;ARG1_33267 380.46350000000285 380.46350000000285 538.056641687932 206.80350000000288 206.80350000000288 292.4643144462203 1319.9650000000029 1319.9650000000029 1866.7124048577982 5.72311E-12;760.927 5.72311E-12;413.607 5.72313E-12;2639.93 0 Exp 2,1(0.34);Exp 4,1(0.34);Hill,1(0.34) 1.8064731651927493 5.467163801193237 1.513624906539917 2.090334892272949 0.29051345150618474 1.863204002380371 -231.60086560064053 751.010332267311 -125.80278957478907 408.2191895747929 -820.6637697055402 2605.1018363722105 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0031399 7 regulation of protein modification process 444 469 34 32 18 17 13 13 55 456 2023 0.63257 0.48995 0.8741 2.77 688621;24832;81687;24426;25283;24367;361921;24854;114494;29397;24232;29657;81639 tslp;thy1;mmp9;gstp1;gclc;fgg;ect2;clu;ccna2;ccl11;c3;arntl;alox15 TSLP_32811;THY1_33010;MMP9_32531;GSTP1_8762;GCLC_8699;FGG_8639;ECT2_8523;CLU_32773;CCNA2_8221;CCL11_33230;C3_8175;ARNTL_8086;ALOX15_8036 325.6101461538466 131.7 5.72311E-12 385.44937342954745 333.8089199293498 377.47044342253804 206.81358923076965 39.9158 5.72311E-12 267.02534317219516 206.74578930031174 256.2007298127518 763.4471615384621 397.209 5.72313E-12 947.0393896383094 806.388490767396 957.8914087358482 344.675;5.72311E-12;728.316;14.7631;131.7;42.4612;10.0162;935.649;14.384;986.476;234.759;22.9134;766.819 244.2;5.72311E-12;443.137;9.42992;39.9158;20.6424;3.29405;808.484;4.89199;552.974;129.148;11.4115;421.048 560.435;5.72313E-12;2039.06;25.7196;397.209;98.0534;37.7305;1071.05;58.2504;2230.86;694.216;50.1592;2662.07 2 11 2 24426;29397 GSTP1_8762;CCL11_33230 500.61955 500.61955 687.1047809564456 281.20196000000004 281.20196000000004 384.3437048418033 1128.2898 1128.2898 1559.2697303084162 14.7631;986.476 9.42992;552.974 25.7196;2230.86 11 688621;24832;81687;25283;24367;361921;24854;114494;24232;29657;81639 TSLP_32811;THY1_33010;MMP9_32531;GCLC_8699;FGG_8639;ECT2_8523;CLU_32773;CCNA2_8221;C3_8175;ARNTL_8086;ALOX15_8036 293.79025454545507 131.7 351.9016212413242 193.28843090909143 39.9158 263.59644058824614 697.1121363636369 397.209 895.3578715557483 344.675;5.72311E-12;728.316;131.7;42.4612;10.0162;935.649;14.384;234.759;22.9134;766.819 244.2;5.72311E-12;443.137;39.9158;20.6424;3.29405;808.484;4.89199;129.148;11.4115;421.048 560.435;5.72313E-12;2039.06;397.209;98.0534;37.7305;1071.05;58.2504;694.216;50.1592;2662.07 0 Exp 2,2(0.16);Exp 4,5(0.39);Hill,2(0.16);Linear,1(0.08);Poly 2,2(0.16);Power,1(0.08) 2.001945760732199 27.21178424358368 1.5021449327468872 3.5281898975372314 0.7081360053379442 1.863204002380371 116.07747993911025 535.1428123685829 61.656959181138404 351.97021928040095 248.6306849783782 1278.2636380985457 DOWN 0.15384615384615385 0.8461538461538461 0.0 GO:0071229 5 cellular response to acid chemical 95 99 9 9 6 8 6 6 62 93 2386 0.98499 0.04634 0.04634 6.06 684352;362282;25283;312495;84032;170913 twf2;pck1;gclc;cyp26b1;col3a1;abcb1a TWF2_10109;PCK1_9439;GCLC_8699;CYP26B1_8418;COL3A1_8354;ABCB1A_7938 206.1858666666667 172.6905 18.1872 173.14449066333773 148.16159080225194 116.33646898980929 122.56461666666667 104.38065 10.0176 122.83647699214457 77.24645748064742 80.10424995840299 799.4001833333333 709.1345 36.7271 645.7201948677474 689.9731745179452 662.5747336460238 3.5 209.79250000000002 138.399;529.244;131.7;18.1872;212.603;206.982 90.7363;356.883;39.9158;10.0176;119.81;118.025 299.165;1021.06;397.209;36.7271;1510.69;1531.55 2 4 2 362282;312495 PCK1_9439;CYP26B1_8418 273.7156 273.7156 361.3717288514972 183.4503 183.4503 245.27087649898422 528.89355 528.89355 696.0284685350197 529.244;18.1872 356.883;10.0176 1021.06;36.7271 4 684352;25283;84032;170913 TWF2_10109;GCLC_8699;COL3A1_8354;ABCB1A_7938 172.421 172.6905 43.30031628060016 92.121775 104.38065 37.26033742792059 934.6535000000001 953.9495000000001 678.4285040338935 138.399;131.7;212.603;206.982 90.7363;39.9158;119.81;118.025 299.165;397.209;1510.69;1531.55 0 Exp 4,1(0.17);Hill,1(0.17);Linear,1(0.17);Poly 2,3(0.5) 1.8199908309415114 10.971557140350342 1.611412525177002 2.090334892272949 0.1939719834620433 1.8410675525665283 67.64141972624054 344.7303136070928 24.274964458919186 220.85426887441415 282.71641861474245 1316.0839480519242 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0019439 5 aromatic compound catabolic process 57 68 5 5 4 4 3 3 65 65 2414 0.89408 0.27203 0.42691 4.41 25315;24296;116599 ephx1;cyp1a1;blvra EPHX1_8567;CYP1A1_8415;BLVRA_8151 156.03846666666666 39.2381 12.8863 225.5107403886195 121.22723752658766 204.16524663934217 105.37935333333333 18.9587 9.13136 158.27198112471623 80.58435225969816 143.4550844384952 273.9873 81.6965 19.3234 388.3284419019163 214.7881051250886 351.32174980465334 39.2381;12.8863;415.991 18.9587;9.13136;288.048 81.6965;19.3234;720.942 2 1 2 25315;24296 EPHX1_8567;CYP1A1_8415 26.0622 26.0622 18.633536476471672 14.04503 14.04503 6.948978755025805 50.50995 50.50995 44.10444197362663 39.2381;12.8863 18.9587;9.13136 81.6965;19.3234 1 116599 BLVRA_8151 415.991 415.991 288.048 288.048 720.942 720.942 415.991 288.048 720.942 0 Exp 2,1(0.34);Exp 4,2(0.67) 3.6782451711536353 19.10429584980011 1.5686544179916382 15.48720932006836 7.901024090295988 2.0484321117401123 -99.15095920363504 411.2278925369683 -73.72225364542605 284.4809603120927 -165.44769971347625 713.4222997134763 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0032355 5 response to estradiol 114 121 13 13 8 10 6 6 62 115 2364 0.95991 0.10105 0.13595 4.96 24314;81687;24426;114494;24232;170913 nqo1;mmp9;gstp1;ccna2;c3;abcb1a NQO1_33055;MMP9_32531;GSTP1_8762;CCNA2_8221;C3_8175;ABCB1A_7938 204.14756666666668 116.33165 14.384 275.4721532760702 224.42737614696247 300.4469853018171 118.72855833333334 63.72746 4.89199 168.86292535865277 131.44543457871188 184.8911492141146 739.1528500000001 390.16855 25.7196 862.4078823348954 830.0415485253341 922.7064320758647 25.6813;728.316;14.7631;14.384;234.759;206.982 7.73944;443.137;9.42992;4.89199;129.148;118.025 86.1211;2039.06;25.7196;58.2504;694.216;1531.55 2 4 2 24314;24426 NQO1_33055;GSTP1_8762 20.2222 20.2222 7.720333258350962 8.584679999999999 8.584679999999999 1.1953498714602508 55.92035 55.92035 42.710310243839245 25.6813;14.7631 7.73944;9.42992 86.1211;25.7196 4 81687;114494;24232;170913 MMP9_32531;CCNA2_8221;C3_8175;ABCB1A_7938 296.11025 220.8705 304.34591673332835 173.8004975 123.5865 188.12849078858315 1080.7691 1112.883 878.728752193933 728.316;14.384;234.759;206.982 443.137;4.89199;129.148;118.025 2039.06;58.2504;694.216;1531.55 0 Exp 4,2(0.34);Hill,1(0.17);Linear,1(0.17);Poly 2,2(0.34) 2.0521415495807647 12.8133465051651 1.5467612743377686 3.5281898975372314 0.723182701109457 1.9694114923477173 -16.27606319822891 424.57119653156235 -16.38992284344458 253.84703951011124 49.082824454268234 1429.2228755457318 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0045087 5 innate immune response 79 87 5 5 4 5 4 4 64 83 2396 0.91977 0.20082 0.29195 4.6 295703;304545;24232;29221 serping1;oasl;c3;arg1 SERPING1_32597;OASL_9389;C3_8175;ARG1_33267 276.174575 155.6858 32.3997 334.6397739575734 382.4134695555907 379.2860460612056 146.23337500000002 78.79785 13.7308 185.48222107196466 205.37214282777163 209.20680242419843 923.505875 477.3025 99.4885 1171.5252519502353 1299.6449147556536 1333.6064640660147 32.3997;76.6126;234.759;760.927 13.7308;28.4477;129.148;413.607 99.4885;260.389;694.216;2639.93 0 4 0 4 295703;304545;24232;29221 SERPING1_32597;OASL_9389;C3_8175;ARG1_33267 276.174575 155.6858 334.6397739575734 146.23337500000002 78.79785 185.48222107196466 923.505875 477.3025 1171.5252519502353 32.3997;76.6126;234.759;760.927 13.7308;28.4477;129.148;413.607 99.4885;260.389;694.216;2639.93 0 Exp 2,1(0.25);Exp 4,2(0.5);Poly 2,1(0.25) 1.6611512852147032 6.671447277069092 1.513624906539917 1.8927439451217651 0.17471126491634864 1.6325392127037048 -51.77240347842195 604.1215534784219 -35.53920165052534 328.0059516505254 -224.58887191123074 2071.6006219112305 DOWN 0.0 1.0 0.0 GO:0051240 5 positive regulation of multicellular organismal process 484 516 29 27 17 19 14 14 54 502 1977 0.59813 0.52213 0.87969 2.71 684352;688621;25671;316351;81687;81919;24367;361921;312495;24854;29397;24232;29657;170913 twf2;tslp;smad1;npas2;mmp9;fut1;fgg;ect2;cyp26b1;clu;ccl11;c3;arntl;abcb1a TWF2_10109;TSLP_32811;SMAD1_32578;NPAS2_9350;MMP9_32531;FUT1_8668;FGG_8639;ECT2_8523;CYP26B1_8418;CLU_32773;CCL11_33230;C3_8175;ARNTL_8086;ABCB1A_7938 282.3414357142857 172.6905 10.0162 346.47618256643807 295.09776451150674 338.9802815733178 180.5282007142857 84.85445 3.29405 248.85346534237442 182.94830289216966 237.5856527749277 687.1846214285715 429.79999999999995 36.7271 766.8019559962023 767.7724929787234 791.9346137593833 138.399;344.675;21.9973;21.0878;728.316;240.861;42.4612;10.0162;18.1872;935.649;986.476;234.759;22.9134;206.982 90.7363;244.2;5.02186;11.3305;443.137;78.9726;20.6424;3.29405;10.0176;808.484;552.974;129.148;11.4115;118.025 299.165;560.435;80.1461;43.5624;2039.06;847.87;98.0534;37.7305;36.7271;1071.05;2230.86;694.216;50.1592;1531.55 2 12 2 312495;29397 CYP26B1_8418;CCL11_33230 502.3316 502.3316 684.6835766269847 281.49580000000003 281.49580000000003 383.9281523286356 1133.79355 1133.79355 1551.486252414505 18.1872;986.476 10.0176;552.974 36.7271;2230.86 12 684352;688621;25671;316351;81687;81919;24367;361921;24854;24232;29657;170913 TWF2_10109;TSLP_32811;SMAD1_32578;NPAS2_9350;MMP9_32531;FUT1_8668;FGG_8639;ECT2_8523;CLU_32773;C3_8175;ARNTL_8086;ABCB1A_7938 245.67640833333334 172.6905 298.31037077845457 163.7002675 84.85445 240.0524040081691 612.7498 429.79999999999995 658.5999574214532 138.399;344.675;21.9973;21.0878;728.316;240.861;42.4612;10.0162;935.649;234.759;22.9134;206.982 90.7363;244.2;5.02186;11.3305;443.137;78.9726;20.6424;3.29405;808.484;129.148;11.4115;118.025 299.165;560.435;80.1461;43.5624;2039.06;847.87;98.0534;37.7305;1071.05;694.216;50.1592;1531.55 0 Exp 2,2(0.15);Exp 4,6(0.43);Linear,1(0.08);Poly 2,4(0.29);Power,1(0.08) 2.0697232946914856 30.00392258167267 1.5467612743377686 3.442979335784912 0.6188136201119447 1.9344776272773743 100.8461122165528 463.8367592120187 50.170783759123395 310.88561766944804 285.50919303014587 1088.860049826997 DOWN 0.14285714285714285 0.8571428571428571 0.0 GO:0048260 7 positive regulation of receptor-mediated endocytosis 16 17 2 2 2 2 2 2 66 15 2464 0.99053 0.073823 0.073823 11.76 24854;24232 clu;c3 CLU_32773;C3_8175 585.204 585.204 234.759 495.6040718658394 666.6809393077287 482.02324920286736 468.81600000000003 468.81600000000003 129.148 480.3630923041445 547.7873336494389 467.19991157025936 882.633 882.633 694.216 266.4618767816505 926.4391335546071 259.1601379533359 0.0 234.759 0.5 585.204 935.649;234.759 808.484;129.148 1071.05;694.216 0 2 0 2 24854;24232 CLU_32773;C3_8175 585.204 585.204 495.6040718658394 468.81600000000003 468.81600000000003 480.3630923041445 882.633 882.633 266.4618767816505 935.649;234.759 808.484;129.148 1071.05;694.216 0 Poly 2,2(1) 1.5508048727931112 3.101620316505432 1.5467612743377686 1.5548590421676636 0.005725986544993042 1.550810158252716 -101.66819999999996 1272.0762 -196.93327999999997 1134.56528 513.3356800000001 1251.93032 DOWN 0.0 1.0 0.0 GO:0007507 5 heart development 69 74 8 8 3 5 3 3 65 71 2408 0.86678 0.3164 0.44745 4.05 25682;81687;84032 ppard;mmp9;col3a1 PPARD_9536;MMP9_32531;COL3A1_8354 345.0088 212.603 94.1074 337.1996574489957 439.3618940918707 363.19155891528146 200.23873333333336 119.81 37.7692 214.31833607606538 259.6652168782109 231.01690993491448 1232.7450000000001 1510.69 148.485 975.4529844769555 1372.9111884255062 1007.2644559904602 94.1074;728.316;212.603 37.7692;443.137;119.81 148.485;2039.06;1510.69 0 3 0 3 25682;81687;84032 PPARD_9536;MMP9_32531;COL3A1_8354 345.0088 212.603 337.1996574489957 200.23873333333336 119.81 214.31833607606538 1232.7450000000001 1510.69 975.4529844769555 94.1074;728.316;212.603 37.7692;443.137;119.81 148.485;2039.06;1510.69 0 Exp 5,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 1.858124910292421 5.603231191635132 1.6129854917526245 2.05134654045105 0.2276783335080501 1.9388991594314575 -36.56853347770135 726.5861334777014 -42.28529475721322 442.76276142387985 128.91603538759546 2336.573964612405 DOWN 0.0 1.0 0.0 GO:0010638 7 positive regulation of organelle organization 145 155 6 6 4 6 4 4 64 151 2328 0.60086 0.60264 1.0 2.58 81687;29397;246142;81639 mmp9;ccl11;bmf;alox15 MMP9_32531;CCL11_33230;BMF_8152;ALOX15_8036 650.253 747.5675 119.401 371.7217668983079 604.1493609009917 384.6046764521282 374.7469 432.0925 81.8286 203.62304002618828 351.18561543956963 212.00180882274483 1788.0187500000002 2134.96 220.085 1077.2668988260286 1657.3682543284585 1123.9408139376108 728.316;986.476;119.401;766.819 443.137;552.974;81.8286;421.048 2039.06;2230.86;220.085;2662.07 1 3 1 29397 CCL11_33230 986.476 986.476 552.974 552.974 2230.86 2230.86 986.476 552.974 2230.86 3 81687;246142;81639 MMP9_32531;BMF_8152;ALOX15_8036 538.1786666666667 728.316 363.18269620995613 315.3378666666667 421.048 202.52632963309568 1640.405 2039.06 1268.8644694469933 728.316;119.401;766.819 443.137;81.8286;421.048 2039.06;220.085;2662.07 0 Exp 2,1(0.25);Linear,1(0.25);Poly 2,1(0.25);Power,1(0.25) 1.768864574833815 7.13835608959198 1.5021449327468872 2.05134654045105 0.2723566481677405 1.7924323081970215 285.96566843965815 1014.5403315603417 175.1963207743355 574.2974792256646 732.2971891504917 2843.7403108495087 DOWN 0.25 0.75 0.0 GO:1903096 10 protein localization to meiotic spindle midzone 1 1 1 1 1 1 1 1 67 0 2479 1.0 0.026698 0.026698 100.0 315852 ttk TTK_32727 737.351 737.351 737.351 737.351 446.625 446.625 446.625 446.625 2108.09 2108.09 2108.09 2108.09 0.0 737.351 0.0 737.351 737.351 446.625 2108.09 0 1 0 1 315852 TTK_32727 737.351 737.351 446.625 446.625 2108.09 2108.09 737.351 446.625 2108.09 0 Linear,1(1) 1.5111545324325562 1.5111545324325562 1.5111545324325562 1.5111545324325562 0.0 1.5111545324325562 737.351 737.351 446.625 446.625 2108.09 2108.09 DOWN 0.0 1.0 0.0 GO:0046700 5 heterocycle catabolic process 52 63 5 5 4 4 3 3 65 60 2419 0.91461 0.2357 0.2357 4.76 24296;116599;26760 cyp1a1;blvra;akr7a3 CYP1A1_8415;BLVRA_8151;AKR7A3_8015 160.54486666666665 52.7573 12.8863 222.11926849434593 139.45674962085306 213.48957619924857 103.19578666666666 12.408 9.13136 160.0950957184402 88.95972864454976 152.9952561115797 319.0508 216.887 19.3234 361.79448101003425 280.4732609478673 353.45985021542157 12.8863;415.991;52.7573 9.13136;288.048;12.408 19.3234;720.942;216.887 2 1 2 24296;26760 CYP1A1_8415;AKR7A3_8015 32.8218 32.8218 28.193054472688832 10.769680000000001 10.769680000000001 2.3169343635070763 118.1052 118.1052 139.69856127562662 12.8863;52.7573 9.13136;12.408 19.3234;216.887 1 116599 BLVRA_8151 415.991 415.991 288.048 288.048 720.942 720.942 415.991 288.048 720.942 0 Exp 2,1(0.34);Exp 4,1(0.34);Hill,1(0.34) 3.356089888839726 18.611830472946167 1.5559667348861694 15.48720932006836 8.039546540970871 1.5686544179916382 -90.80674746986361 411.89648080319694 -77.96886868693485 284.3604420202682 -90.35819636482984 728.4597963648298 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0099040 8 ceramide translocation 2 2 2 2 2 2 2 2 66 0 2479 1.0 7.0258E-4 7.0258E-4 100.0 24646;170913 abcb1b;abcb1a ABCB1B_7939;ABCB1A_7938 113.88804999999999 113.88804999999999 20.7941 131.65472666488282 94.95271533817913 128.902572727214 63.139275000000005 63.139275000000005 8.25355 77.62013667568004 51.97550365898731 75.99753967361325 794.38075 794.38075 57.2115 1042.5147511144025 644.4403247505235 1020.7216780509452 0.0 20.7941 0.0 20.7941 20.7941;206.982 8.25355;118.025 57.2115;1531.55 0 2 0 2 24646;170913 ABCB1B_7939;ABCB1A_7938 113.88804999999999 113.88804999999999 131.65472666488282 63.139275000000005 63.139275000000005 77.62013667568004 794.38075 794.38075 1042.5147511144025 20.7941;206.982 8.25355;118.025 57.2115;1531.55 0 Hill,1(0.5);Poly 2,1(0.5) 3.418388002805463 8.078481674194336 1.8874764442443848 6.191005229949951 3.0430543874039144 4.039240837097168 -68.57609200000003 296.35219200000006 -44.436746 170.715296 -650.4709799999997 2239.2324799999997 DOWN 0.0 1.0 0.0 GO:0032496 5 response to lipopolysaccharide 176 189 17 17 13 12 10 10 58 179 2300 0.98987 0.026179 0.031092 5.29 116669;25682;362282;81687;24426;24296;245920;29221;24646;170913 vwf;ppard;pck1;mmp9;gstp1;cyp1a1;cxcl10;arg1;abcb1b;abcb1a VWF_32396;PPARD_9536;PCK1_9439;MMP9_32531;GSTP1_8762;CYP1A1_8415;CXCL10_8408;ARG1_33267;ABCB1B_7939;ABCB1A_7938 305.82243000000005 150.5447 12.8863 326.0519438531537 251.1479910912612 322.69981911639417 177.515447 77.8971 4.11644 193.15497843875238 142.84923728073986 190.08790830932497 953.1717500000001 584.7725 19.3234 1015.887448231695 865.1054560531203 1038.044505988555 8.5 744.6215 19.6764;94.1074;529.244;728.316;14.7631;12.8863;670.528;760.927;20.7941;206.982 4.11644;37.7692;356.883;443.137;9.42992;9.13136;374.802;413.607;8.25355;118.025 94.078;148.485;1021.06;2039.06;25.7196;19.3234;1955.3;2639.93;57.2115;1531.55 3 7 3 362282;24426;24296 PCK1_9439;GSTP1_8762;CYP1A1_8415 185.63113333333334 14.7631 297.578951202405 125.14809333333334 9.42992 200.6883716371602 355.3676666666666 25.7196 576.5153422396435 529.244;14.7631;12.8863 356.883;9.42992;9.13136 1021.06;25.7196;19.3234 7 116669;25682;81687;245920;29221;24646;170913 VWF_32396;PPARD_9536;MMP9_32531;CXCL10_8408;ARG1_33267;ABCB1B_7939;ABCB1A_7938 357.3329857142857 206.982 345.8735707314473 199.95859857142858 118.025 201.4427469046595 1209.3735 1531.55 1087.192206598071 19.6764;94.1074;728.316;670.528;760.927;20.7941;206.982 4.11644;37.7692;443.137;374.802;413.607;8.25355;118.025 94.078;148.485;2039.06;1955.3;2639.93;57.2115;1531.55 0 Exp 2,2(0.2);Exp 4,2(0.2);Exp 5,1(0.1);Hill,2(0.2);Linear,2(0.2);Poly 2,1(0.1) 2.741867765957591 38.15425741672516 1.513624906539917 15.48720932006836 4.3369638269596305 1.9951228499412537 103.73334149214463 507.91151850785536 57.7967510396344 297.23414296036566 323.5181861734442 1582.8253138265559 DOWN 0.3 0.7 0.0 GO:0003008 3 system process 296 309 19 17 10 13 8 8 60 301 2178 0.55535 0.59452 1.0 2.59 25682;288583;25154;25283;24367;170945;29397;170913 ppard;plod3;pgr;gclc;fgg;chrna2;ccl11;abcb1a PPARD_9536;PLOD3_9507;PGR_32824;GCLC_8699;FGG_8639;CHRNA2_32401;CCL11_33230;ABCB1A_7938 348.931575 185.2305 42.4612 369.5852976919546 265.8586298173084 321.0262747530826 204.46030000000002 109.9965 20.6424 241.96630408926188 146.89665948680047 197.46853420493775 935.0936750000001 760.191 98.0534 786.235368212845 797.2816596530937 772.2159613286032 94.1074;882.629;283.618;131.7;42.4612;163.479;986.476;206.982 37.7692;625.677;138.711;39.9158;20.6424;101.968;552.974;118.025 148.485;1106.02;1554.21;397.209;98.0534;414.362;2230.86;1531.55 1 7 1 29397 CCL11_33230 986.476 986.476 552.974 552.974 2230.86 2230.86 986.476 552.974 2230.86 7 25682;288583;25154;25283;24367;170945;170913 PPARD_9536;PLOD3_9507;PGR_32824;GCLC_8699;FGG_8639;CHRNA2_32401;ABCB1A_7938 257.8538 163.479 286.2469866942184 154.67262857142856 101.968 212.532492233805 749.9842 414.362 633.5473392538872 94.1074;882.629;283.618;131.7;42.4612;163.479;206.982 37.7692;625.677;138.711;39.9158;20.6424;101.968;118.025 148.485;1106.02;1554.21;397.209;98.0534;414.362;1531.55 0 Exp 4,1(0.13);Exp 5,1(0.13);Hill,1(0.13);Poly 2,4(0.5);Power,1(0.13) 1.9291751688686138 15.655469298362732 1.5405861139297485 2.8176381587982178 0.37858757263964515 1.9131878018379211 92.82203017966663 605.0411198203334 36.78620584863998 372.1343941513601 390.26036173743535 1479.926988262565 DOWN 0.125 0.875 0.0 GO:0003018 5 vascular process in circulatory system 70 73 10 9 7 7 5 5 63 68 2411 0.98792 0.043291 0.043291 6.85 25682;288583;25283;24367;170913 ppard;plod3;gclc;fgg;abcb1a PPARD_9536;PLOD3_9507;GCLC_8699;FGG_8639;ABCB1A_7938 271.57592 131.7 42.4612 346.81123993678756 169.44610585852743 217.499782290141 168.40588 39.9158 20.6424 258.38188747335215 90.25159119774338 161.0511058124717 656.26348 397.209 98.0534 633.4339194322105 597.7452870678433 635.9582937529318 2.5 169.341 94.1074;882.629;131.7;42.4612;206.982 37.7692;625.677;39.9158;20.6424;118.025 148.485;1106.02;397.209;98.0534;1531.55 0 5 0 5 25682;288583;25283;24367;170913 PPARD_9536;PLOD3_9507;GCLC_8699;FGG_8639;ABCB1A_7938 271.57592 131.7 346.81123993678756 168.40588 39.9158 258.38188747335215 656.26348 397.209 633.4339194322105 94.1074;882.629;131.7;42.4612;206.982 37.7692;625.677;39.9158;20.6424;118.025 148.485;1106.02;397.209;98.0534;1531.55 0 Exp 4,1(0.2);Exp 5,1(0.2);Hill,1(0.2);Poly 2,2(0.4) 2.035499902145979 10.334771752357483 1.7160688638687134 2.8176381587982178 0.43121054231442774 1.9388991594314575 -32.417535080981565 575.5693750809816 -58.07583010168577 394.88759010168576 101.03416918301741 1211.4927908169825 DOWN 0.0 1.0 0.0 GO:0006952 4 defense response 257 279 26 25 13 15 9 9 59 270 2209 0.79543 0.32504 0.55276 3.23 688621;25671;295703;304545;312495;245920;29397;24232;29221 tslp;smad1;serping1;oasl;cyp26b1;cxcl10;ccl11;c3;arg1 TSLP_32811;SMAD1_32578;SERPING1_32597;OASL_9389;CYP26B1_8418;CXCL10_8408;CCL11_33230;C3_8175;ARG1_33267 349.61797777777775 234.759 18.1872 367.98514803864293 392.65906084289554 382.24582103411853 196.8832177777778 129.148 5.02186 207.93530999500865 226.070239899292 213.48578750596351 950.8324111111111 560.435 36.7271 1031.6201022166267 1033.0458999176024 1092.2480889273193 344.675;21.9973;32.3997;76.6126;18.1872;670.528;986.476;234.759;760.927 244.2;5.02186;13.7308;28.4477;10.0176;374.802;552.974;129.148;413.607 560.435;80.1461;99.4885;260.389;36.7271;1955.3;2230.86;694.216;2639.93 2 7 2 312495;29397 CYP26B1_8418;CCL11_33230 502.3316 502.3316 684.6835766269847 281.49580000000003 281.49580000000003 383.9281523286356 1133.79355 1133.79355 1551.486252414505 18.1872;986.476 10.0176;552.974 36.7271;2230.86 7 688621;25671;295703;304545;245920;24232;29221 TSLP_32811;SMAD1_32578;SERPING1_32597;OASL_9389;CXCL10_8408;C3_8175;ARG1_33267 305.98551428571426 234.759 304.01302313011985 172.7081942857143 129.148 173.24660579876948 898.5577999999999 560.435 1001.726234182239 344.675;21.9973;32.3997;76.6126;670.528;234.759;760.927 244.2;5.02186;13.7308;28.4477;374.802;129.148;413.607 560.435;80.1461;99.4885;260.389;1955.3;694.216;2639.93 0 Exp 2,3(0.34);Exp 4,4(0.45);Poly 2,1(0.12);Power,1(0.12) 1.765785018776767 15.976143836975098 1.513624906539917 2.090334892272949 0.1937783136801645 1.7183171510696411 109.2010143925311 590.0349411630245 61.0321485810388 332.73428697451686 276.8406109962482 1624.824211225974 DOWN 0.2222222222222222 0.7777777777777778 0.0 GO:0008285 6 negative regulation of cell population proliferation 190 199 11 11 7 8 6 6 62 193 2286 0.72129 0.44151 0.65004 3.02 24832;25671;25682;81687;24426;29221 thy1;smad1;ppard;mmp9;gstp1;arg1 THY1_33010;SMAD1_32578;PPARD_9536;MMP9_32531;GSTP1_8762;ARG1_33267 270.0184666666676 58.05235 5.72311E-12 369.20246321024194 395.7923801663719 387.3557613514524 151.49416333333428 23.599559999999997 5.72311E-12 215.07157739287828 226.17754625369562 227.5028235870853 822.223450000001 114.31555 5.72313E-12 1191.622454346589 1201.693717021367 1248.794694145638 5.72311E-12;21.9973;94.1074;728.316;14.7631;760.927 5.72311E-12;5.02186;37.7692;443.137;9.42992;413.607 5.72313E-12;80.1461;148.485;2039.06;25.7196;2639.93 1 5 1 24426 GSTP1_8762 14.7631 14.7631 9.42992 9.42992 25.7196 25.7196 14.7631 9.42992 25.7196 5 24832;25671;25682;81687;29221 THY1_33010;SMAD1_32578;PPARD_9536;MMP9_32531;ARG1_33267 321.06954000000115 94.1074 388.38316504065557 179.90701200000115 37.7692 227.51934968846982 981.5242200000012 148.485 1258.8207089213654 5.72311E-12;21.9973;94.1074;728.316;760.927 5.72311E-12;5.02186;37.7692;443.137;413.607 5.72313E-12;80.1461;148.485;2039.06;2639.93 0 Exp 2,1(0.17);Exp 4,2(0.34);Exp 5,1(0.17);Hill,1(0.17);Linear,1(0.17) 2.0153764790631463 12.588479995727539 1.513624906539917 3.5281898975372314 0.7257281361174047 1.9010515809059143 -25.405031236964362 565.4419645702997 -20.598940110763294 323.5872667774319 -131.27309653608052 1775.7199965360824 DOWN 0.16666666666666666 0.8333333333333334 0.0 GO:0042221 3 response to chemical 909 981 73 71 45 48 34 34 34 947 1532 0.98109 0.033626 0.057661 3.47 116669;684352;360243;25671;89776;25682;288583;25154;362282;24314;316351;81687;291234;24426;25283;24367;25315;361921;312495;24296;245920;84032;24854;170945;113902;114494;29397;686019;24232;25612;29221;81639;24646;170913 vwf;twf2;top2a;smad1;slc22a7;ppard;plod3;pgr;pck1;nqo1;npas2;mmp9;mki67;gstp1;gclc;fgg;ephx1;ect2;cyp26b1;cyp1a1;cxcl10;col3a1;clu;chrna2;ces1d;ccna2;ccl11;casq1;c3;asns;arg1;alox15;abcb1b;abcb1a VWF_32396;TWF2_10109;TOP2A_10059;SMAD1_32578;SLC22A7_9847;PPARD_9536;PLOD3_9507;PGR_32824;PCK1_9439;NQO1_33055;NPAS2_9350;MMP9_32531;MKI67_9232;GSTP1_8762;GCLC_8699;FGG_8639;EPHX1_8567;ECT2_8523;CYP26B1_8418;CYP1A1_8415;CXCL10_8408;COL3A1_8354;CLU_32773;CHRNA2_32401;CES1D_32914;CCNA2_8221;CCL11_33230;CASQ1_32992;C3_8175;ASNS_8091;ARG1_33267;ALOX15_8036;ABCB1B_7939;ABCB1A_7938 249.8456705882353 112.90369999999999 10.0162 316.40360260265163 206.6496519849604 290.76117894359044 151.38199058823534 38.8425 3.29405 212.82643125990487 121.10954209666988 190.50207077165786 685.4915529411765 274.023 17.0564 833.2235294046543 593.0411322967396 809.1145203849226 19.6764;138.399;86.3883;21.9973;49.1516;94.1074;882.629;283.618;529.244;25.6813;21.0878;728.316;21.9311;14.7631;131.7;42.4612;39.2381;10.0162;18.1872;12.8863;670.528;212.603;935.649;163.479;11.0684;14.384;986.476;147.66;234.759;191.145;760.927;766.819;20.7941;206.982 4.11644;90.7363;26.6888;5.02186;13.5995;37.7692;625.677;138.711;356.883;7.73944;11.3305;443.137;6.82654;9.42992;39.9158;20.6424;18.9587;3.29405;10.0176;9.13136;374.802;119.81;808.484;101.968;4.18343;4.89199;552.974;96.6023;129.148;113.564;413.607;421.048;8.25355;118.025 94.078;299.165;262.273;80.1461;161.307;148.485;1106.02;1554.21;1021.06;86.1211;43.5624;2039.06;76.1794;25.7196;397.209;98.0534;81.6965;37.7305;36.7271;19.3234;1955.3;1510.69;1071.05;414.362;17.0564;58.2504;2230.86;285.773;694.216;510.267;2639.93;2662.07;57.2115;1531.55 7 27 7 362282;24314;24426;25315;312495;24296;29397 PCK1_9439;NQO1_33055;GSTP1_8762;EPHX1_8567;CYP26B1_8418;CYP1A1_8415;CCL11_33230 232.3537142857143 25.6813 382.5855695287588 137.87628857142857 10.0176 223.89305943798138 500.21538571428573 81.6965 845.0115158906168 529.244;25.6813;14.7631;39.2381;18.1872;12.8863;986.476 356.883;7.73944;9.42992;18.9587;10.0176;9.13136;552.974 1021.06;86.1211;25.7196;81.6965;36.7271;19.3234;2230.86 27 116669;684352;360243;25671;89776;25682;288583;25154;316351;81687;291234;25283;24367;361921;245920;84032;24854;170945;113902;114494;686019;24232;25612;29221;81639;24646;170913 VWF_32396;TWF2_10109;TOP2A_10059;SMAD1_32578;SLC22A7_9847;PPARD_9536;PLOD3_9507;PGR_32824;NPAS2_9350;MMP9_32531;MKI67_9232;GCLC_8699;FGG_8639;ECT2_8523;CXCL10_8408;COL3A1_8354;CLU_32773;CHRNA2_32401;CES1D_32914;CCNA2_8221;CASQ1_32992;C3_8175;ASNS_8091;ARG1_33267;ALOX15_8036;ABCB1B_7939;ABCB1A_7938 254.3806222222222 138.399 305.25799601259786 154.88346888888893 90.7363 214.14961476102658 733.5261148148146 299.165 839.500140947346 19.6764;138.399;86.3883;21.9973;49.1516;94.1074;882.629;283.618;21.0878;728.316;21.9311;131.7;42.4612;10.0162;670.528;212.603;935.649;163.479;11.0684;14.384;147.66;234.759;191.145;760.927;766.819;20.7941;206.982 4.11644;90.7363;26.6888;5.02186;13.5995;37.7692;625.677;138.711;11.3305;443.137;6.82654;39.9158;20.6424;3.29405;374.802;119.81;808.484;101.968;4.18343;4.89199;96.6023;129.148;113.564;413.607;421.048;8.25355;118.025 94.078;299.165;262.273;80.1461;161.307;148.485;1106.02;1554.21;43.5624;2039.06;76.1794;397.209;98.0534;37.7305;1955.3;1510.69;1071.05;414.362;17.0564;58.2504;285.773;694.216;510.267;2639.93;2662.07;57.2115;1531.55 0 Exp 2,3(0.09);Exp 4,11(0.33);Exp 5,2(0.06);Hill,5(0.15);Linear,2(0.06);Poly 2,10(0.3);Power,1(0.03) 2.094974785551683 83.88586676120758 1.5021449327468872 15.48720932006836 2.45287932849764 1.892466127872467 143.49064103475445 356.2007001417162 79.84310417790925 222.92087699856137 405.41410639649894 965.5689994858544 DOWN 0.20588235294117646 0.7941176470588235 0.0 GO:0010996 5 response to auditory stimulus 12 13 2 2 2 2 2 2 66 11 2468 0.9957 0.04532 0.04532 15.38 25283;245920 gclc;cxcl10 GCLC_8699;CXCL10_8408 401.11400000000003 401.11400000000003 131.7 381.00893269318505 207.84048761070756 265.44021098810936 207.3589 207.3589 39.9158 236.80030294579447 87.2377627823664 164.9733562194359 1176.2545 1176.2545 397.209 1101.7367118057289 617.3790885660264 767.5547740256154 0.0 131.7 0.5 401.11400000000003 131.7;670.528 39.9158;374.802 397.209;1955.3 0 2 0 2 25283;245920 GCLC_8699;CXCL10_8408 401.11400000000003 401.11400000000003 381.00893269318505 207.3589 207.3589 236.80030294579447 1176.2545 1176.2545 1101.7367118057289 131.7;670.528 39.9158;374.802 397.209;1955.3 0 Exp 2,1(0.5);Hill,1(0.5) 1.9132925111205683 3.8284939527511597 1.8538048267364502 1.9746891260147095 0.0854781077586412 1.9142469763755798 -126.93743999999987 929.1654399999998 -120.82957599999997 535.547376 -350.6746799999996 2703.1836799999996 DOWN 0.0 1.0 0.0 GO:0033044 7 regulation of chromosome organization 75 76 4 4 4 3 3 3 65 73 2406 0.85708 0.33127 0.45521 3.95 315852;360243;291234 ttk;top2a;mki67 TTK_32727;TOP2A_10059;MKI67_9232 281.8901333333333 86.3883 21.9311 395.75514331025863 224.49503033838974 356.1668352452372 160.04677999999998 26.6888 6.82654 248.38263722904065 122.25333119695388 224.50409987138167 815.5141333333335 262.273 76.1794 1123.2639873631904 652.8867534729474 1010.7641137435565 737.351;86.3883;21.9311 446.625;26.6888;6.82654 2108.09;262.273;76.1794 0 3 0 3 315852;360243;291234 TTK_32727;TOP2A_10059;MKI67_9232 281.8901333333333 86.3883 395.75514331025863 160.04677999999998 26.6888 248.38263722904065 815.5141333333335 262.273 1123.2639873631904 737.351;86.3883;21.9311 446.625;26.6888;6.82654 2108.09;262.273;76.1794 0 Exp 4,2(0.67);Linear,1(0.34) 1.7856676130022247 5.3935307264328 1.5111545324325562 1.9603345394134521 0.24901715163548324 1.922041654586792 -165.9489701724459 729.7292368391126 -121.02463363378291 441.11819363378294 -455.57872699796144 2086.606993664628 DOWN 0.0 1.0 0.0 GO:0009636 4 response to toxic substance 240 257 21 20 14 15 11 11 57 246 2233 0.96364 0.075084 0.10064 4.28 24314;81687;24426;25315;361921;24296;170945;25612;29221;24646;170913 nqo1;mmp9;gstp1;ephx1;ect2;cyp1a1;chrna2;asns;arg1;abcb1b;abcb1a NQO1_33055;MMP9_32531;GSTP1_8762;EPHX1_8567;ECT2_8523;CYP1A1_8415;CHRNA2_32401;ASNS_8091;ARG1_33267;ABCB1B_7939;ABCB1A_7938 197.6571 39.2381 10.0162 280.87749987464997 201.3102868133652 274.89574291389096 113.37345636363635 18.9587 3.29405 162.46444795513068 115.95404764751025 160.3530792104641 676.6337818181819 86.1211 19.3234 942.7813398456376 685.4381041633459 914.7265823688418 25.6813;728.316;14.7631;39.2381;10.0162;12.8863;163.479;191.145;760.927;20.7941;206.982 7.73944;443.137;9.42992;18.9587;3.29405;9.13136;101.968;113.564;413.607;8.25355;118.025 86.1211;2039.06;25.7196;81.6965;37.7305;19.3234;414.362;510.267;2639.93;57.2115;1531.55 4 7 4 24314;24426;25315;24296 NQO1_33055;GSTP1_8762;EPHX1_8567;CYP1A1_8415 23.142200000000003 20.2222 12.123226017855147 11.314855000000001 9.28064 5.1488700759001444 53.215149999999994 53.70805 35.58391411433918 25.6813;14.7631;39.2381;12.8863 7.73944;9.42992;18.9587;9.13136 86.1211;25.7196;81.6965;19.3234 7 81687;361921;170945;25612;29221;24646;170913 MMP9_32531;ECT2_8523;CHRNA2_32401;ASNS_8091;ARG1_33267;ABCB1B_7939;ABCB1A_7938 297.3799 191.145 315.44849615644597 171.69265714285714 113.564 181.8404516779211 1032.873 510.267 1036.1483224577855 728.316;10.0162;163.479;191.145;760.927;20.7941;206.982 443.137;3.29405;101.968;113.564;413.607;8.25355;118.025 2039.06;37.7305;414.362;510.267;2639.93;57.2115;1531.55 0 Exp 2,1(0.1);Exp 4,4(0.37);Hill,2(0.19);Linear,1(0.1);Poly 2,3(0.28) 2.658449674655791 40.11991083621979 1.513624906539917 15.48720932006836 4.1527281864583685 2.0484321117401123 31.66910480826121 363.64509519173885 17.363103031526663 209.38380969574604 119.48561375560178 1233.7819498807617 DOWN 0.36363636363636365 0.6363636363636364 0.0 GO:0032787 7 monocarboxylic acid metabolic process 180 207 14 14 13 12 12 12 56 195 2284 0.99739 0.0074227 0.010318 5.8 286989;25682;362282;24426;25315;312495;24296;113902;24232;25612;81639;252898 ugt2b7;ppard;pck1;gstp1;ephx1;cyp26b1;cyp1a1;ces1d;c3;asns;alox15;acox2 UGT2B7_33032;PPARD_9536;PCK1_9439;GSTP1_8762;EPHX1_8567;CYP26B1_8418;CYP1A1_8415;CES1D_32914;C3_8175;ASNS_8091;ALOX15_8036;ACOX2_32902 224.19025833333333 66.67275000000001 11.0684 289.4564332471891 202.6575112313852 282.5350782639289 129.78692583333333 28.36395 4.18343 170.95180788921846 114.02267609549429 161.82365910897997 634.1195833333333 126.75450000000001 17.0564 920.602897963328 606.0853682102231 942.1824488456459 9.5 636.2985 34.7126;94.1074;529.244;14.7631;39.2381;18.1872;12.8863;11.0684;234.759;191.145;766.819;743.353 14.7729;37.7692;356.883;9.42992;18.9587;10.0176;9.13136;4.18343;129.148;113.564;421.048;432.537 105.024;148.485;1021.06;25.7196;81.6965;36.7271;19.3234;17.0564;694.216;510.267;2662.07;2287.79 6 6 6 286989;362282;24426;25315;312495;24296 UGT2B7_33032;PCK1_9439;GSTP1_8762;EPHX1_8567;CYP26B1_8418;CYP1A1_8415 108.17188333333335 26.4499 206.5679775067899 69.86558 12.39525 140.66172783888132 214.92510000000001 59.2118 396.35712737739937 34.7126;529.244;14.7631;39.2381;18.1872;12.8863 14.7729;356.883;9.42992;18.9587;10.0176;9.13136 105.024;1021.06;25.7196;81.6965;36.7271;19.3234 6 25682;113902;24232;25612;81639;252898 PPARD_9536;CES1D_32914;C3_8175;ASNS_8091;ALOX15_8036;ACOX2_32902 340.20863333333335 212.952 330.68428675161243 189.70827166666666 121.356 189.4488354124575 1053.3140666666668 602.2415 1133.880382820316 94.1074;11.0684;234.759;191.145;766.819;743.353 37.7692;4.18343;129.148;113.564;421.048;432.537 148.485;17.0564;694.216;510.267;2662.07;2287.79 0 Exp 2,2(0.17);Exp 4,5(0.42);Exp 5,2(0.17);Linear,1(0.09);Poly 2,2(0.17) 2.4436045839169456 40.64851272106171 1.5021449327468872 15.48720932006836 4.018234872037559 1.8721401691436768 60.41486367247842 387.96565299418825 33.061834976105715 226.51201669056093 113.23945899657372 1154.999707670093 CONFLICT 0.5 0.5 0.0 GO:0001666 4 response to hypoxia 168 175 14 14 9 11 7 7 61 168 2311 0.90893 0.18248 0.22802 4.0 25682;362282;81687;24296;114494;24646;170913 ppard;pck1;mmp9;cyp1a1;ccna2;abcb1b;abcb1a PPARD_9536;PCK1_9439;MMP9_32531;CYP1A1_8415;CCNA2_8221;ABCB1B_7939;ABCB1A_7938 229.53054285714285 94.1074 12.8863 287.01237444263535 203.80487040382857 290.0117554291171 139.72729999999999 37.7692 4.89199 183.75785488146363 120.0668562055708 180.28464931565276 696.4200428571429 148.485 19.3234 834.6711858463543 709.8388871430875 899.6041038644249 94.1074;529.244;728.316;12.8863;14.384;20.7941;206.982 37.7692;356.883;443.137;9.13136;4.89199;8.25355;118.025 148.485;1021.06;2039.06;19.3234;58.2504;57.2115;1531.55 2 5 2 362282;24296 PCK1_9439;CYP1A1_8415 271.06515 271.06515 365.1200311878889 183.00718 183.00718 245.897542812743 520.1917 520.1917 708.3347428227561 529.244;12.8863 356.883;9.13136 1021.06;19.3234 5 25682;81687;114494;24646;170913 PPARD_9536;MMP9_32531;CCNA2_8221;ABCB1B_7939;ABCB1A_7938 212.91670000000005 94.1074 298.3762872913664 122.415348 37.7692 184.99410759980782 766.91138 148.485 947.544170776472 94.1074;728.316;14.384;20.7941;206.982 37.7692;443.137;4.89199;8.25355;118.025 148.485;2039.06;58.2504;57.2115;1531.55 0 Exp 4,2(0.29);Exp 5,1(0.15);Hill,1(0.15);Linear,2(0.29);Poly 2,1(0.15) 2.937407837431993 30.79414439201355 1.611412525177002 15.48720932006836 5.155688694702279 1.9388991594314575 16.90880038460105 442.1522853296847 3.597576068106264 275.8570239318937 78.08697526411072 1314.753110450175 DOWN 0.2857142857142857 0.7142857142857143 0.0 GO:2001014 6 regulation of skeletal muscle cell differentiation 9 9 3 3 3 3 3 3 65 6 2473 0.99995 0.0013631 0.0013631 33.33 259241;312495;29657 nr1d2;cyp26b1;arntl NR1D2_9358;CYP26B1_8418;ARNTL_8086 23.424466666666664 22.9134 18.1872 5.510602843004888 22.66635143785947 6.270339193323451 8.261223333333334 10.0176 3.35457 4.306062528881035 7.723132691506211 4.087156102609347 66.97476666666667 50.1592 36.7271 41.30758134342085 66.2838649328999 44.60527491261658 0.0 18.1872 0.0 18.1872 29.1728;18.1872;22.9134 3.35457;10.0176;11.4115 114.038;36.7271;50.1592 2 1 2 259241;312495 NR1D2_9358;CYP26B1_8418 23.68 23.68 7.76799225540293 6.686085 6.686085 4.7114736962494 75.38255 75.38255 54.667061649635066 29.1728;18.1872 3.35457;10.0176 114.038;36.7271 1 29657 ARNTL_8086 22.9134 22.9134 11.4115 11.4115 50.1592 50.1592 22.9134 11.4115 50.1592 0 Exp 4,3(1) 2.504340314906449 7.715691089630127 2.090334892272949 3.442979335784912 0.7557818592543012 2.1823768615722656 17.18863251844695 29.660300814886384 3.388454867347555 13.133991799319112 20.2308379786017 113.71869535473164 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0042149 6 cellular response to glucose starvation 22 22 2 2 2 2 2 2 66 20 2459 0.98051 0.11526 0.11526 9.09 363131;25612 pik3r4;asns PIK3R4_9484;ASNS_8091 573.3865000000001 573.3865000000001 191.145 540.5711134018353 353.9127940799441 442.5830017792523 424.39599999999996 424.39599999999996 113.564 439.5828300195539 245.92387973429672 359.90063770953316 899.6185 899.6185 510.267 550.626171830308 676.0624062463581 450.81540234970447 0.5 573.3865000000001 955.628;191.145 735.228;113.564 1288.97;510.267 0 2 0 2 363131;25612 PIK3R4_9484;ASNS_8091 573.3865000000001 573.3865000000001 540.5711134018353 424.39599999999996 424.39599999999996 439.5828300195539 899.6185 899.6185 550.626171830308 955.628;191.145 735.228;113.564 1288.97;510.267 0 Poly 2,2(1) 1.6466450538092128 3.3072468042373657 1.5018656253814697 1.805381178855896 0.214617906057355 1.6536234021186829 -175.80683999999985 1322.5798399999999 -184.83471999999995 1033.6267199999998 136.4895600000002 1662.7474399999999 DOWN 0.0 1.0 0.0 GO:0032270 7 positive regulation of cellular protein metabolic process 403 428 26 25 16 14 11 11 57 417 2062 0.52346 0.60731 1.0 2.57 688621;24832;81687;25283;24367;361921;24854;29397;24232;29657;81639 tslp;thy1;mmp9;gclc;fgg;ect2;clu;ccl11;c3;arntl;alox15 TSLP_32811;THY1_33010;MMP9_32531;GCLC_8699;FGG_8639;ECT2_8523;CLU_32773;CCL11_33230;C3_8175;ARNTL_8086;ALOX15_8036 382.1622545454551 234.759 5.72311E-12 394.2318458693466 384.7655635501262 383.42178708672714 243.11406818181868 129.148 5.72311E-12 275.9352803008341 238.70133650916313 262.91242597807366 894.6221000000005 560.435 5.72313E-12 976.3085234440971 927.6442137765005 981.2265619387565 344.675;5.72311E-12;728.316;131.7;42.4612;10.0162;935.649;986.476;234.759;22.9134;766.819 244.2;5.72311E-12;443.137;39.9158;20.6424;3.29405;808.484;552.974;129.148;11.4115;421.048 560.435;5.72313E-12;2039.06;397.209;98.0534;37.7305;1071.05;2230.86;694.216;50.1592;2662.07 1 10 1 29397 CCL11_33230 986.476 986.476 552.974 552.974 2230.86 2230.86 986.476 552.974 2230.86 10 688621;24832;81687;25283;24367;361921;24854;24232;29657;81639 TSLP_32811;THY1_33010;MMP9_32531;GCLC_8699;FGG_8639;ECT2_8523;CLU_32773;C3_8175;ARNTL_8086;ALOX15_8036 321.7308800000006 183.22949999999997 357.8442972603358 212.1280750000006 84.5319 269.93585535703227 760.9983100000005 478.822 916.9816690013117 344.675;5.72311E-12;728.316;131.7;42.4612;10.0162;935.649;234.759;22.9134;766.819 244.2;5.72311E-12;443.137;39.9158;20.6424;3.29405;808.484;129.148;11.4115;421.048 560.435;5.72313E-12;2039.06;397.209;98.0534;37.7305;1071.05;694.216;50.1592;2662.07 0 Exp 2,2(0.19);Exp 4,3(0.28);Hill,2(0.19);Linear,1(0.1);Poly 2,2(0.19);Power,1(0.1) 1.9376364134134918 22.056799173355103 1.5021449327468872 3.442979335784912 0.6046069134749543 1.863204002380371 149.18612165551198 615.1383874353982 80.04673811712343 406.181398246514 317.6606325723334 1471.5835674276677 DOWN 0.09090909090909091 0.9090909090909091 0.0 GO:0045596 6 negative regulation of cell differentiation 184 195 11 10 8 8 7 7 61 188 2291 0.85531 0.2617 0.35772 3.59 24832;25682;81687;245920;84032;29397;29657 thy1;ppard;mmp9;cxcl10;col3a1;ccl11;arntl THY1_33010;PPARD_9536;MMP9_32531;CXCL10_8408;COL3A1_8354;CCL11_33230;ARNTL_8086 387.84911428571513 212.603 5.72311E-12 398.91093560965544 480.770314855766 412.23868236771756 219.98624285714368 119.81 5.72311E-12 230.86097050861395 276.72504622578845 241.20995689966944 1133.5077428571437 1510.69 5.72313E-12 1022.2988398742939 1321.751084828332 1018.1257458593549 5.72311E-12;94.1074;728.316;670.528;212.603;986.476;22.9134 5.72311E-12;37.7692;443.137;374.802;119.81;552.974;11.4115 5.72313E-12;148.485;2039.06;1955.3;1510.69;2230.86;50.1592 1 6 1 29397 CCL11_33230 986.476 986.476 552.974 552.974 2230.86 2230.86 986.476 552.974 2230.86 6 24832;25682;81687;245920;84032;29657 THY1_33010;PPARD_9536;MMP9_32531;CXCL10_8408;COL3A1_8354;ARNTL_8086 288.07796666666763 153.3552 327.6277667141508 164.4882833333343 78.78960000000001 195.1510895435669 950.6157000000009 829.5875000000001 986.4776262795511 5.72311E-12;94.1074;728.316;670.528;212.603;22.9134 5.72311E-12;37.7692;443.137;374.802;119.81;11.4115 5.72313E-12;148.485;2039.06;1955.3;1510.69;50.1592 0 Exp 2,1(0.15);Exp 4,1(0.15);Exp 5,1(0.15);Hill,1(0.15);Linear,1(0.15);Poly 2,1(0.15);Power,1(0.15) 2.048110024282641 14.744698166847229 1.6129854917526245 3.442979335784912 0.6054672479116175 1.9388991594314575 92.33175763728553 683.3664709341447 48.96204254603714 391.0104431682502 376.1781640059212 1890.8373217083663 DOWN 0.14285714285714285 0.8571428571428571 0.0 GO:0007062 5 sister chromatid cohesion 12 13 1 1 1 1 1 1 67 12 2467 0.95468 0.29717 0.29717 7.69 293502 kif22 KIF22_8963 17.3097 17.3097 17.3097 17.3097 3.12114 3.12114 3.12114 3.12114 90.6321 90.6321 90.6321 90.6321 0.0 17.3097 17.3097 3.12114 90.6321 0 1 0 1 293502 KIF22_8963 17.3097 17.3097 3.12114 3.12114 90.6321 90.6321 17.3097 3.12114 90.6321 0 Hill,1(1) 1.8598893880844116 1.8598893880844116 1.8598893880844116 1.8598893880844116 0.0 1.8598893880844116 17.3097 17.3097 3.12114 3.12114 90.6321 90.6321 DOWN 0.0 1.0 0.0 GO:0042127 5 regulation of cell population proliferation 436 466 29 28 18 20 14 14 54 452 2027 0.74938 0.35774 0.63315 3.0 688621;24832;25671;25682;25154;81687;24426;81919;64191;245920;24854;114494;29397;29221 tslp;thy1;smad1;ppard;pgr;mmp9;gstp1;fut1;dhcr7;cxcl10;clu;ccna2;ccl11;arg1 TSLP_32811;THY1_33010;SMAD1_32578;PPARD_9536;PGR_32824;MMP9_32531;GSTP1_8762;FUT1_8668;DHCR7_8466;CXCL10_8408;CLU_32773;CCNA2_8221;CCL11_33230;ARG1_33267 375.5717000000004 262.2395 5.72311E-12 364.3798666826015 383.3379364291938 350.2722164692395 225.9220907142861 108.8418 5.72311E-12 254.5041292769618 224.7523542118775 245.00044023338927 978.0595071428577 704.1524999999999 5.72313E-12 936.2197760730327 993.0790959543492 907.5138792246648 344.675;5.72311E-12;21.9973;94.1074;283.618;728.316;14.7631;240.861;161.702;670.528;935.649;14.384;986.476;760.927 244.2;5.72311E-12;5.02186;37.7692;138.711;443.137;9.42992;78.9726;50.9087;374.802;808.484;4.89199;552.974;413.607 560.435;5.72313E-12;80.1461;148.485;1554.21;2039.06;25.7196;847.87;481.517;1955.3;1071.05;58.2504;2230.86;2639.93 2 12 2 24426;29397 GSTP1_8762;CCL11_33230 500.61955 500.61955 687.1047809564456 281.20196000000004 281.20196000000004 384.3437048418033 1128.2898 1128.2898 1559.2697303084162 14.7631;986.476 9.42992;552.974 25.7196;2230.86 12 688621;24832;25671;25682;25154;81687;81919;64191;245920;24854;114494;29221 TSLP_32811;THY1_33010;SMAD1_32578;PPARD_9536;PGR_32824;MMP9_32531;FUT1_8668;DHCR7_8466;CXCL10_8408;CLU_32773;CCNA2_8221;ARG1_33267 354.7303916666672 262.2395 332.68135218092357 216.70877916666714 108.8418 249.94365564757737 953.0211250000006 704.1524999999999 900.0309932960979 344.675;5.72311E-12;21.9973;94.1074;283.618;728.316;240.861;161.702;670.528;935.649;14.384;760.927 244.2;5.72311E-12;5.02186;37.7692;138.711;443.137;78.9726;50.9087;374.802;808.484;4.89199;413.607 560.435;5.72313E-12;80.1461;148.485;1554.21;2039.06;847.87;481.517;1955.3;1071.05;58.2504;2639.93 0 Exp 2,4(0.29);Exp 4,4(0.29);Exp 5,1(0.08);Hill,1(0.08);Linear,1(0.08);Poly 2,2(0.15);Power,1(0.08) 1.899056384947161 27.36167275905609 1.513624906539917 3.5281898975372314 0.5489168793076005 1.8233012557029724 184.69785323294803 566.4455467670527 92.60467497598015 359.2395064525921 487.63759743260636 1468.4814168531088 DOWN 0.14285714285714285 0.8571428571428571 0.0 GO:0048469 4 cell maturation 37 38 3 3 3 3 3 3 65 35 2444 0.98267 0.079068 0.079068 7.89 25154;24367;24232 pgr;fgg;c3 PGR_32824;FGG_8639;C3_8175 186.94606666666664 234.759 42.4612 127.49003095149577 131.8092847228172 131.96141887629088 96.16713333333333 129.148 20.6424 65.58087946233518 67.37356387627453 68.38655665044193 782.1598 694.216 98.0534 732.0509510271264 520.02107660012 703.279280870236 0.5 138.6101 283.618;42.4612;234.759 138.711;20.6424;129.148 1554.21;98.0534;694.216 0 3 0 3 25154;24367;24232 PGR_32824;FGG_8639;C3_8175 186.94606666666664 234.759 127.49003095149577 96.16713333333333 129.148 65.58087946233518 782.1598 694.216 732.0509510271264 283.618;42.4612;234.759 138.711;20.6424;129.148 1554.21;98.0534;694.216 0 Exp 4,1(0.34);Poly 2,2(0.67) 1.8865348391644827 5.904985547065735 1.5405861139297485 2.8176381587982178 0.735530207102865 1.5467612743377686 42.677515436540716 331.2146178967926 21.955382047240988 170.3788846194257 -46.23383472662442 1610.5534347266243 DOWN 0.0 1.0 0.0 GO:0051128 5 regulation of cellular component organization 515 547 30 27 19 21 17 17 51 530 1949 0.80894 0.2791 0.45638 3.11 684352;315852;360243;24832;25671;25682;81687;291234;25283;361921;245920;24854;306575;29397;24232;246142;81639 twf2;ttk;top2a;thy1;smad1;ppard;mmp9;mki67;gclc;ect2;cxcl10;clu;ckap2;ccl11;c3;bmf;alox15 TWF2_10109;TTK_32727;TOP2A_10059;THY1_33010;SMAD1_32578;PPARD_9536;MMP9_32531;MKI67_9232;GCLC_8699;ECT2_8523;CXCL10_8408;CLU_32773;CKAP2_8324;CCL11_33230;C3_8175;BMF_8152;ALOX15_8036 336.23981764705917 131.7 5.72311E-12 367.6481311158793 308.9429410694594 360.41751997734343 204.9157323529415 81.8286 5.72311E-12 249.35506392946408 185.09302235634925 241.69334593159394 844.6249529411768 299.165 5.72313E-12 948.5473402354128 783.019928336303 937.2550469287227 138.399;737.351;86.3883;5.72311E-12;21.9973;94.1074;728.316;21.9311;131.7;10.0162;670.528;935.649;32.2386;986.476;234.759;119.401;766.819 90.7363;446.625;26.6888;5.72311E-12;5.02186;37.7692;443.137;6.82654;39.9158;3.29405;374.802;808.484;15.2683;552.974;129.148;81.8286;421.048 299.165;2108.09;262.273;5.72313E-12;80.1461;148.485;2039.06;76.1794;397.209;37.7305;1955.3;1071.05;76.7052;2230.86;694.216;220.085;2662.07 1 16 1 29397 CCL11_33230 986.476 986.476 552.974 552.974 2230.86 2230.86 986.476 552.974 2230.86 16 684352;315852;360243;24832;25671;25682;81687;291234;25283;361921;245920;24854;306575;24232;246142;81639 TWF2_10109;TTK_32727;TOP2A_10059;THY1_33010;SMAD1_32578;PPARD_9536;MMP9_32531;MKI67_9232;GCLC_8699;ECT2_8523;CXCL10_8408;CLU_32773;CKAP2_8324;C3_8175;BMF_8152;ALOX15_8036 295.60005625000036 125.5505 337.97532817889686 183.16209062500033 60.87219999999999 240.29580021076256 757.9852625000003 280.71900000000005 907.528597368801 138.399;737.351;86.3883;5.72311E-12;21.9973;94.1074;728.316;21.9311;131.7;10.0162;670.528;935.649;32.2386;234.759;119.401;766.819 90.7363;446.625;26.6888;5.72311E-12;5.02186;37.7692;443.137;6.82654;39.9158;3.29405;374.802;808.484;15.2683;129.148;81.8286;421.048 299.165;2108.09;262.273;5.72313E-12;80.1461;148.485;2039.06;76.1794;397.209;37.7305;1955.3;1071.05;76.7052;694.216;220.085;2662.07 0 Exp 2,2(0.12);Exp 4,5(0.3);Exp 5,1(0.06);Hill,2(0.12);Linear,2(0.12);Poly 2,4(0.24);Power,1(0.06) 1.7803514702608487 30.446030616760254 1.5021449327468872 2.0582168102264404 0.1987623052423572 1.8538048267364502 161.47098987074534 511.00864542337297 86.37985923217116 323.4516054737119 393.7141697417046 1295.5357361406489 DOWN 0.058823529411764705 0.9411764705882353 0.0 GO:0050920 5 regulation of chemotaxis 65 68 5 5 3 3 2 2 66 66 2413 0.72797 0.54821 0.70309 2.94 24426;245920 gstp1;cxcl10 GSTP1_8762;CXCL10_8408 342.64555 342.64555 14.7631 463.69580765411825 217.28292557633753 428.46496569874705 192.11596 192.11596 9.42992 258.35707542423376 122.26775244889082 238.72753135228783 990.5097999999999 990.5097999999999 25.7196 1364.419385684651 621.6317722488037 1260.7530532649348 14.7631;670.528 9.42992;374.802 25.7196;1955.3 1 1 1 24426 GSTP1_8762 14.7631 14.7631 9.42992 9.42992 25.7196 25.7196 14.7631 9.42992 25.7196 1 245920 CXCL10_8408 670.528 670.528 374.802 374.802 1955.3 1955.3 670.528 374.802 1955.3 0 Exp 2,1(0.5);Exp 4,1(0.5) 2.5574548796992103 5.381994724273682 1.8538048267364502 3.5281898975372314 1.18396903788075 2.690997362136841 -300.00405199999994 985.2951519999999 -165.94867839999995 550.1805984 -900.4789919999998 2881.498592 CONFLICT 0.5 0.5 0.0 GO:0034614 6 cellular response to reactive oxygen species 66 70 7 7 5 6 5 5 63 65 2414 0.99009 0.037076 0.037076 7.14 24314;81687;361921;114494;29221 nqo1;mmp9;ect2;ccna2;arg1 NQO1_33055;MMP9_32531;ECT2_8523;CCNA2_8221;ARG1_33267 307.86490000000003 25.6813 10.0162 398.91003522507424 295.0625442589525 394.53495629892956 174.533896 7.73944 3.29405 231.96197329324377 168.10564092742447 231.0593323213811 972.2184 86.1211 37.7305 1266.213503482215 920.5907952465909 1235.97565073696 2.5 376.99865 25.6813;728.316;10.0162;14.384;760.927 7.73944;443.137;3.29405;4.89199;413.607 86.1211;2039.06;37.7305;58.2504;2639.93 1 4 1 24314 NQO1_33055 25.6813 25.6813 7.73944 7.73944 86.1211 86.1211 25.6813 7.73944 86.1211 4 81687;361921;114494;29221 MMP9_32531;ECT2_8523;CCNA2_8221;ARG1_33267 378.4108 371.35 423.07697671419885 216.23251 209.24949500000002 245.25492861236054 1193.742725 1048.6552 1345.5762104353541 728.316;10.0162;14.384;760.927 443.137;3.29405;4.89199;413.607 2039.06;37.7305;58.2504;2639.93 0 Exp 2,1(0.2);Exp 4,2(0.4);Hill,1(0.2);Linear,1(0.2) 1.7816770826206636 9.000379204750061 1.513624906539917 2.1727771759033203 0.29201819153668346 1.6358354091644287 -41.79516262267981 657.5249626226798 -28.789738267644054 377.85753026764405 -137.66667138324453 2082.103471383244 DOWN 0.2 0.8 0.0 GO:0033622 7 integrin activation 4 4 2 2 1 1 1 1 67 3 2476 0.99593 0.10265 0.10265 25.0 309186 fermt3 FERMT3_32542 539.113 539.113 539.113 539.113 334.248 334.248 334.248 334.248 1187.86 1187.86 1187.86 1187.86 0.0 539.113 0.0 539.113 539.113 334.248 1187.86 0 1 0 1 309186 FERMT3_32542 539.113 539.113 334.248 334.248 1187.86 1187.86 539.113 334.248 1187.86 0 Exp 2,1(1) 1.6703740358352661 1.6703740358352661 1.6703740358352661 1.6703740358352661 0.0 1.6703740358352661 539.113 539.113 334.248 334.248 1187.86 1187.86 DOWN 0.0 1.0 0.0 GO:0033632 7 regulation of cell-cell adhesion mediated by integrin 4 4 1 1 1 1 1 1 67 3 2476 0.99593 0.10265 0.10265 25.0 309186 fermt3 FERMT3_32542 539.113 539.113 539.113 539.113 334.248 334.248 334.248 334.248 1187.86 1187.86 1187.86 1187.86 0.0 539.113 0.0 539.113 539.113 334.248 1187.86 0 1 0 1 309186 FERMT3_32542 539.113 539.113 334.248 334.248 1187.86 1187.86 539.113 334.248 1187.86 0 Exp 2,1(1) 1.6703740358352661 1.6703740358352661 1.6703740358352661 1.6703740358352661 0.0 1.6703740358352661 539.113 539.113 334.248 334.248 1187.86 1187.86 DOWN 0.0 1.0 0.0 GO:0051592 6 response to calcium ion 51 56 5 5 3 4 3 3 65 53 2426 0.93961 0.18667 0.18667 5.36 24367;361921;81639 fgg;ect2;alox15 FGG_8639;ECT2_8523;ALOX15_8036 273.0988 42.4612 10.0162 427.8818720421326 229.50273230937412 404.5881969838089 148.32815 20.6424 3.29405 236.34155104413503 124.23997711943153 223.47807295118892 932.6179666666667 98.0534 37.7305 1498.0530580612635 779.283003607543 1416.8091553255547 1.5 404.64009999999996 42.4612;10.0162;766.819 20.6424;3.29405;421.048 98.0534;37.7305;2662.07 0 3 0 3 24367;361921;81639 FGG_8639;ECT2_8523;ALOX15_8036 273.0988 42.4612 427.8818720421326 148.32815 20.6424 236.34155104413503 932.6179666666667 98.0534 1498.0530580612635 42.4612;10.0162;766.819 20.6424;3.29405;421.048 98.0534;37.7305;2662.07 0 Exp 2,1(0.34);Exp 4,2(0.67) 1.905953148123435 5.955618500709534 1.5021449327468872 2.8176381587982178 0.7239996904135699 1.6358354091644287 -211.09511944957723 757.2927194495771 -119.11749190740909 415.7737919074091 -762.5886525440782 2627.824585877411 DOWN 0.0 1.0 0.0 GO:0044089 6 positive regulation of cellular component biogenesis 110 121 7 7 6 7 6 6 62 115 2364 0.95991 0.10105 0.13595 4.96 684352;24832;24854;29397;246142;81639 twf2;thy1;clu;ccl11;bmf;alox15 TWF2_10109;THY1_33010;CLU_32773;CCL11_33230;BMF_8152;ALOX15_8036 491.12400000000093 452.609 5.72311E-12 452.2785668775372 493.5969412728472 445.2951229793705 325.84515000000096 255.89215000000002 5.72311E-12 320.8073149042931 320.81075331682877 307.4421603063337 1080.5383333333343 685.1075 5.72313E-12 1126.32674589866 1122.5513522172876 1146.4259693964664 138.399;5.72311E-12;935.649;986.476;119.401;766.819 90.7363;5.72311E-12;808.484;552.974;81.8286;421.048 299.165;5.72313E-12;1071.05;2230.86;220.085;2662.07 1 5 1 29397 CCL11_33230 986.476 986.476 552.974 552.974 2230.86 2230.86 986.476 552.974 2230.86 5 684352;24832;24854;246142;81639 TWF2_10109;THY1_33010;CLU_32773;BMF_8152;ALOX15_8036 392.0536000000011 138.399 426.7116079974845 280.4193800000012 90.7363 336.4081037511302 850.4740000000013 299.165 1090.3178170228612 138.399;5.72311E-12;935.649;119.401;766.819 90.7363;5.72311E-12;808.484;81.8286;421.048 299.165;5.72313E-12;1071.05;220.085;2662.07 0 Exp 2,1(0.17);Hill,1(0.17);Poly 2,3(0.5);Power,1(0.17) 1.7078331239109004 10.299731254577637 1.5021449327468872 1.9814788103103638 0.19116235840196008 1.6990222334861755 129.22577458724794 853.0222254127539 69.1458357591606 582.5444642408414 179.28923504030092 1981.7874316263678 DOWN 0.16666666666666666 0.8333333333333334 0.0 GO:0040011 2 locomotion 209 224 14 14 7 8 4 4 64 220 2259 0.27186 0.86268 0.51635 1.79 25682;245920;29397;24232 ppard;cxcl10;ccl11;c3 PPARD_9536;CXCL10_8408;CCL11_33230;C3_8175 496.4676 452.6435 94.1074 408.57083301704245 527.6074597641098 459.17000281584393 273.67330000000004 251.97500000000002 37.7692 234.36026520514665 290.4803469959629 263.6709207440973 1257.2152500000002 1324.758 148.485 996.9214847303252 1253.7774913322248 1072.581879216077 94.1074;670.528;986.476;234.759 37.7692;374.802;552.974;129.148 148.485;1955.3;2230.86;694.216 1 3 1 29397 CCL11_33230 986.476 986.476 552.974 552.974 2230.86 2230.86 986.476 552.974 2230.86 3 25682;245920;24232 PPARD_9536;CXCL10_8408;C3_8175 333.13146666666665 234.759 300.5379072174645 180.57306666666668 129.148 174.30197985167393 932.667 694.216 926.7088380969502 94.1074;670.528;234.759 37.7692;374.802;129.148 148.485;1955.3;694.216 0 Exp 2,1(0.25);Exp 5,1(0.25);Poly 2,1(0.25);Power,1(0.25) 1.821830583518305 7.32094407081604 1.5467612743377686 1.9814788103103638 0.19629525344169002 1.8963519930839539 96.06818364329837 896.8670163567017 44.00024009895631 503.3463599010438 280.2321949642809 2234.198305035719 DOWN 0.25 0.75 0.0 GO:0019985 8 translesion synthesis 4 4 2 2 2 2 2 2 66 2 2477 0.99993 0.0040711 0.0040711 50.0 299112;300795 pole2;pclaf POLE2_9520;NS5ATP9_9367 146.10800013579902 146.10800013579902 2.71598E-7 206.62791497915939 59.2443486818164 166.14604226642527 73.75750013579899 73.75750013579899 2.71598E-7 104.30885663468476 29.907431924093128 83.87300285606032 329.2470001357995 329.2470001357995 2.71599E-7 465.625572578605 133.50414782754086 374.40171658208004 0.0 2.71598E-7 0.0 2.71598E-7 2.71598E-7;292.216 2.71598E-7;147.515 2.71599E-7;658.494 0 2 0 2 299112;300795 POLE2_9520;NS5ATP9_9367 146.10800013579902 146.10800013579902 206.62791497915939 73.75750013579899 73.75750013579899 104.30885663468476 329.2470001357995 329.2470001357995 465.625572578605 2.71598E-7;292.216 2.71598E-7;147.515 2.71599E-7;658.494 0 Exp 2,1(0.5);Hill,1(0.5) 1.65772291825458 3.3154884576797485 1.6493386030197144 1.6661498546600342 0.011887350035103618 1.6577442288398743 -140.26367959803497 432.47967986963295 -70.80719959803496 218.32219986963293 -316.07711959803345 974.5711198696324 DOWN 0.0 1.0 0.0 GO:0071363 6 cellular response to growth factor stimulus 136 141 14 13 8 10 7 7 61 134 2345 0.96814 0.07898 0.098701 4.96 684352;25671;24426;25283;24854;114494;29221 twf2;smad1;gstp1;gclc;clu;ccna2;arg1 TWF2_10109;SMAD1_32578;GSTP1_8762;GCLC_8699;CLU_32773;CCNA2_8221;ARG1_33267 288.2599142857143 131.7 14.384 389.4869287981838 303.39232391725295 380.2143579955985 196.01241000000002 39.9158 4.89199 307.0655456221846 194.7376665439231 295.5132308137984 653.0671571428571 299.165 25.7196 947.6861485046054 743.0900174110888 988.3003013001478 138.399;21.9973;14.7631;131.7;935.649;14.384;760.927 90.7363;5.02186;9.42992;39.9158;808.484;4.89199;413.607 299.165;80.1461;25.7196;397.209;1071.05;58.2504;2639.93 1 6 1 24426 GSTP1_8762 14.7631 14.7631 9.42992 9.42992 25.7196 25.7196 14.7631 9.42992 25.7196 6 684352;25671;25283;24854;114494;29221 TWF2_10109;SMAD1_32578;GCLC_8699;CLU_32773;CCNA2_8221;ARG1_33267 333.8427166666667 135.0495 405.69277725047266 227.10949166666668 65.32605 324.07415797801576 757.6250833333334 348.187 992.9244784349239 138.399;21.9973;131.7;935.649;14.384;760.927 90.7363;5.02186;39.9158;808.484;4.89199;413.607 299.165;80.1461;397.209;1071.05;58.2504;2639.93 0 Exp 2,1(0.15);Exp 4,3(0.43);Hill,1(0.15);Poly 2,2(0.29) 1.8736300749346608 13.68603229522705 1.513624906539917 3.5281898975372314 0.7108911785121421 1.6932154893875122 -0.2760404171740447 576.7958689886027 -31.464929575544403 423.48974957554435 -48.98856642461021 1355.1228807103244 DOWN 0.14285714285714285 0.8571428571428571 0.0 GO:0071385 8 cellular response to glucocorticoid stimulus 47 51 8 8 5 8 5 5 63 46 2433 0.99797 0.010612 0.010612 9.8 362282;24426;25315;29221;170913 pck1;gstp1;ephx1;arg1;abcb1a PCK1_9439;GSTP1_8762;EPHX1_8567;ARG1_33267;ABCB1A_7938 310.23084 206.982 14.7631 324.99706397392737 306.7225446614391 331.524967699862 183.38072400000001 118.025 9.42992 190.17888472834954 172.36293780440894 184.14068264444825 1059.9912199999999 1021.06 25.7196 1089.3654362231905 1259.6641504315235 1143.1073401775895 1.5 123.11005 529.244;14.7631;39.2381;760.927;206.982 356.883;9.42992;18.9587;413.607;118.025 1021.06;25.7196;81.6965;2639.93;1531.55 3 2 3 362282;24426;25315 PCK1_9439;GSTP1_8762;EPHX1_8567 194.4150666666667 39.2381 290.22847440267356 128.42387333333332 18.9587 197.9087639040882 376.15869999999995 81.6965 559.2017689436166 529.244;14.7631;39.2381 356.883;9.42992;18.9587 1021.06;25.7196;81.6965 2 29221;170913 ARG1_33267;ABCB1A_7938 483.9545 483.9545 391.6982659043821 265.81600000000003 265.81600000000003 209.00803659668208 2085.74 2085.74 783.7430141315464 760.927;206.982 413.607;118.025 2639.93;1531.55 0 Exp 2,1(0.2);Exp 4,2(0.4);Linear,1(0.2);Poly 2,1(0.2) 2.015654134144871 10.589135885238647 1.513624906539917 3.5281898975372314 0.8167797013048839 1.8874764442443848 25.358353206848676 595.1033267931514 16.681581658026943 350.079866341973 105.12031424836402 2014.8621257516356 UP 0.6 0.4 0.0 GO:0030162 7 regulation of proteolysis 214 230 12 11 8 6 5 5 63 225 2254 0.41253 0.74985 0.82987 2.17 295703;81687;25283;24854;24232 serping1;mmp9;gclc;clu;c3 SERPING1_32597;MMP9_32531;GCLC_8699;CLU_32773;C3_8175 412.56474 234.759 32.3997 396.3399242574965 416.43687743154686 385.40044039641504 286.88312 129.148 13.7308 337.99710360541854 274.81968105826064 320.6716316375712 860.2046999999999 694.216 99.4885 750.7932409390086 937.7597530055085 812.4618501560561 32.3997;728.316;131.7;935.649;234.759 13.7308;443.137;39.9158;808.484;129.148 99.4885;2039.06;397.209;1071.05;694.216 0 5 0 5 295703;81687;25283;24854;24232 SERPING1_32597;MMP9_32531;GCLC_8699;CLU_32773;C3_8175 412.56474 234.759 396.3399242574965 286.88312 129.148 337.99710360541854 860.2046999999999 694.216 750.7932409390086 32.3997;728.316;131.7;935.649;234.759 13.7308;443.137;39.9158;808.484;129.148 99.4885;2039.06;397.209;1071.05;694.216 0 Exp 4,1(0.2);Hill,1(0.2);Linear,1(0.2);Poly 2,2(0.4) 1.7569163375519201 8.845973134040833 1.5467612743377686 2.05134654045105 0.23443685090468377 1.7183171510696411 65.15747896794312 759.9720010320568 -9.384403945023962 583.1506439450241 202.10540827549573 1518.3039917245042 DOWN 0.0 1.0 0.0 GO:0070374 9 positive regulation of ERK1 and ERK2 cascade 75 80 9 9 6 6 4 4 64 76 2403 0.93988 0.16314 0.16314 5.0 24367;29397;24232;81639 fgg;ccl11;c3;alox15 FGG_8639;CCL11_33230;C3_8175;ALOX15_8036 507.62879999999996 500.789 42.4612 442.4601769521863 495.2931015053314 465.3261001433589 280.9531 275.098 20.6424 247.94381081427838 273.89205571816854 260.7757219373087 1421.29985 1462.538 98.0534 1221.2739651647196 1384.6266550804935 1297.239874999426 3.0 986.476 42.4612;986.476;234.759;766.819 20.6424;552.974;129.148;421.048 98.0534;2230.86;694.216;2662.07 1 3 1 29397 CCL11_33230 986.476 986.476 552.974 552.974 2230.86 2230.86 986.476 552.974 2230.86 3 24367;24232;81639 FGG_8639;C3_8175;ALOX15_8036 348.01306666666665 234.759 375.2244905621344 190.27946666666665 129.148 207.08441102713002 1151.4464666666668 694.216 1341.7675119054916 42.4612;234.759;766.819 20.6424;129.148;421.048 98.0534;694.216;2662.07 0 Exp 2,1(0.25);Exp 4,1(0.25);Poly 2,1(0.25);Power,1(0.25) 1.8978087515324553 7.848023176193237 1.5021449327468872 2.8176381587982178 0.610023487218972 1.7641200423240662 74.0178265868575 941.2397734131425 37.96816540200723 523.9380345979929 224.45136413857495 2618.148335861425 DOWN 0.25 0.75 0.0 GO:1903672 8 positive regulation of sprouting angiogenesis 16 17 5 5 3 4 2 2 66 15 2464 0.99053 0.073823 0.073823 11.76 25671;81919 smad1;fut1 SMAD1_32578;FUT1_8668 131.42915 131.42915 21.9973 154.76000642557815 213.22235113512332 102.81247047407967 41.99723 41.99723 5.02186 52.291069727763265 69.63391781488758 34.738781592316805 464.00805 464.00805 80.1461 542.8627757689828 750.9199288037546 360.6426776162304 0.0 21.9973 0.5 131.42915 21.9973;240.861 5.02186;78.9726 80.1461;847.87 0 2 0 2 25671;81919 SMAD1_32578;FUT1_8668 131.42915 131.42915 154.76000642557815 41.99723 41.99723 52.291069727763265 464.00805 464.00805 542.8627757689828 21.9973;240.861 5.02186;78.9726 80.1461;847.87 0 Exp 2,1(0.5);Exp 4,1(0.5) 2.15275296029559 4.430224061012268 1.6932154893875122 2.737008571624756 0.7380731666055627 2.215112030506134 -83.05727599999997 345.915576 -30.47449519999998 114.46895519999998 -288.3613719999999 1216.377472 DOWN 0.0 1.0 0.0 GO:0030522 5 intracellular receptor signaling pathway 38 42 4 4 4 4 4 4 64 38 2441 0.99538 0.024263 0.024263 9.52 25682;25154;259241;312495 ppard;pgr;nr1d2;cyp26b1 PPARD_9536;PGR_32824;NR1D2_9358;CYP26B1_8418 106.27135 61.6401 18.1872 122.88585467708099 75.44913583761084 102.58495822889338 47.4630925 23.8934 3.35457 62.630873219285604 32.631872316845545 51.43569061831918 463.365025 131.2615 36.7271 728.7298262663165 293.5861233551097 587.8536903078674 1.5 61.6401 94.1074;283.618;29.1728;18.1872 37.7692;138.711;3.35457;10.0176 148.485;1554.21;114.038;36.7271 2 2 2 259241;312495 NR1D2_9358;CYP26B1_8418 23.68 23.68 7.76799225540293 6.686085 6.686085 4.7114736962494 75.38255 75.38255 54.667061649635066 29.1728;18.1872 3.35457;10.0176 114.038;36.7271 2 25682;25154 PPARD_9536;PGR_32824 188.8627 188.8627 134.00423036673135 88.24010000000001 88.24010000000001 71.37663128517625 851.3475000000001 851.3475000000001 993.9976799834594 94.1074;283.618 37.7692;138.711 148.485;1554.21 0 Exp 4,2(0.5);Exp 5,1(0.25);Poly 2,1(0.25) 1.921306734113649 7.752197027206421 1.5405861139297485 2.1823768615722656 0.28335170460044484 2.0146170258522034 -14.156787583539383 226.6994875835394 -13.91516325489988 108.84134825489988 -250.79020474099008 1177.5202547409901 CONFLICT 0.5 0.5 0.0 GO:0046686 6 response to cadmium ion 39 43 6 6 4 5 4 4 64 39 2440 0.99487 0.026226 0.026226 9.3 81687;25283;29221;170913 mmp9;gclc;arg1;abcb1a MMP9_32531;GCLC_8699;ARG1_33267;ABCB1A_7938 456.98125000000005 467.649 131.7 333.82284828071613 420.53381650564205 333.7608862954518 253.6712 265.81600000000003 39.9158 204.58739949377787 231.54466993141085 207.6442976412674 1651.93725 1785.3049999999998 397.209 951.2850552333144 1512.9561420827492 974.9582674561351 1.5 467.649 728.316;131.7;760.927;206.982 443.137;39.9158;413.607;118.025 2039.06;397.209;2639.93;1531.55 0 4 0 4 81687;25283;29221;170913 MMP9_32531;GCLC_8699;ARG1_33267;ABCB1A_7938 456.98125000000005 467.649 333.82284828071613 253.6712 265.81600000000003 204.58739949377787 1651.93725 1785.3049999999998 951.2850552333144 728.316;131.7;760.927;206.982 443.137;39.9158;413.607;118.025 2039.06;397.209;2639.93;1531.55 0 Exp 2,1(0.25);Hill,1(0.25);Linear,1(0.25);Poly 2,1(0.25) 1.8444181762234926 7.427137017250061 1.513624906539917 2.05134654045105 0.23836693733618125 1.9310827851295471 129.83485868489822 784.1276413151019 53.17554849609766 454.1668515039023 719.6778958713519 2584.196604128648 DOWN 0.0 1.0 0.0 GO:0002683 5 negative regulation of immune system process 126 135 10 10 7 8 5 5 63 130 2349 0.85159 0.29102 0.40611 3.7 24832;295703;84032;29221;81639 thy1;serping1;col3a1;arg1;alox15 THY1_33010;SERPING1_32597;COL3A1_8354;ARG1_33267;ALOX15_8036 354.5497400000012 212.603 5.72311E-12 382.34260277555643 438.47747370967016 392.61438685647084 193.63916000000114 119.81 5.72311E-12 209.41258217577914 239.35380272732053 214.99017069101637 1382.4357000000011 1510.69 5.72313E-12 1303.1008215368242 1621.4383032985138 1323.0368467173535 5.72311E-12;32.3997;212.603;760.927;766.819 5.72311E-12;13.7308;119.81;413.607;421.048 5.72313E-12;99.4885;1510.69;2639.93;2662.07 0 5 0 5 24832;295703;84032;29221;81639 THY1_33010;SERPING1_32597;COL3A1_8354;ARG1_33267;ALOX15_8036 354.5497400000012 212.603 382.34260277555643 193.63916000000114 119.81 209.41258217577914 1382.4357000000011 1510.69 1303.1008215368242 5.72311E-12;32.3997;212.603;760.927;766.819 5.72311E-12;13.7308;119.81;413.607;421.048 5.72313E-12;99.4885;1510.69;2639.93;2662.07 0 Exp 2,2(0.4);Exp 4,1(0.2);Hill,1(0.2);Poly 2,1(0.2) 1.6366087146647956 8.210276484489441 1.5021449327468872 1.863204002380371 0.15135797722109154 1.6129854917526245 19.411672203866317 689.687807796136 10.08093851719039 377.1973814828119 240.21746875107442 2524.6539312489276 DOWN 0.0 1.0 0.0 GO:0033993 5 response to lipid 414 443 35 34 24 24 18 18 50 425 2054 0.98071 0.037816 0.051638 4.06 116669;684352;25682;25154;362282;24314;81687;24426;25315;312495;24296;245920;113902;114494;24232;29221;24646;170913 vwf;twf2;ppard;pgr;pck1;nqo1;mmp9;gstp1;ephx1;cyp26b1;cyp1a1;cxcl10;ces1d;ccna2;c3;arg1;abcb1b;abcb1a VWF_32396;TWF2_10109;PPARD_9536;PGR_32824;PCK1_9439;NQO1_33055;MMP9_32531;GSTP1_8762;EPHX1_8567;CYP26B1_8418;CYP1A1_8415;CXCL10_8408;CES1D_32914;CCNA2_8221;C3_8175;ARG1_33267;ABCB1B_7939;ABCB1A_7938 212.41996111111112 66.67275000000001 11.0684 269.79585767963226 178.64506642971494 267.65700167938803 121.08560722222222 28.36395 4.11644 159.35532868862478 100.23646260818137 157.14096981290425 686.62 121.28150000000001 17.0564 870.8917514204473 617.233573323218 888.3348184673031 19.6764;138.399;94.1074;283.618;529.244;25.6813;728.316;14.7631;39.2381;18.1872;12.8863;670.528;11.0684;14.384;234.759;760.927;20.7941;206.982 4.11644;90.7363;37.7692;138.711;356.883;7.73944;443.137;9.42992;18.9587;10.0176;9.13136;374.802;4.18343;4.89199;129.148;413.607;8.25355;118.025 94.078;299.165;148.485;1554.21;1021.06;86.1211;2039.06;25.7196;81.6965;36.7271;19.3234;1955.3;17.0564;58.2504;694.216;2639.93;57.2115;1531.55 6 12 6 362282;24314;24426;25315;312495;24296 PCK1_9439;NQO1_33055;GSTP1_8762;EPHX1_8567;CYP26B1_8418;CYP1A1_8415 106.66666666666667 21.93425 207.2421205371984 68.69333666666667 9.723759999999999 141.24079959290768 211.77461666666667 59.2118 397.47893717219995 529.244;25.6813;14.7631;39.2381;18.1872;12.8863 356.883;7.73944;9.42992;18.9587;10.0176;9.13136 1021.06;86.1211;25.7196;81.6965;36.7271;19.3234 12 116669;684352;25682;25154;81687;245920;113902;114494;24232;29221;24646;170913 VWF_32396;TWF2_10109;PPARD_9536;PGR_32824;MMP9_32531;CXCL10_8408;CES1D_32914;CCNA2_8221;C3_8175;ARG1_33267;ABCB1B_7939;ABCB1A_7938 265.2966083333334 172.6905 289.517838320268 147.2817425 104.38065 167.12833550377752 924.0426916666667 496.69050000000004 957.004833066186 19.6764;138.399;94.1074;283.618;728.316;670.528;11.0684;14.384;234.759;760.927;20.7941;206.982 4.11644;90.7363;37.7692;138.711;443.137;374.802;4.18343;4.89199;129.148;413.607;8.25355;118.025 94.078;299.165;148.485;1554.21;2039.06;1955.3;17.0564;58.2504;694.216;2639.93;57.2115;1531.55 0 Exp 2,2(0.12);Exp 4,5(0.28);Exp 5,2(0.12);Hill,3(0.17);Linear,2(0.12);Poly 2,4(0.23) 2.2683905438825778 52.601571559906006 1.513624906539917 15.48720932006836 3.322885523030996 1.9131878018379211 87.78063385025611 337.05928837196615 47.4672013133829 194.70401313106157 284.28853743556607 1088.951462564434 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0030833 8 regulation of actin filament polymerization 32 34 3 3 3 3 3 3 65 31 2448 0.98821 0.060429 0.060429 8.82 684352;29397;81639 twf2;ccl11;alox15 TWF2_10109;CCL11_33230;ALOX15_8036 630.5646666666667 766.819 138.399 440.15063557415584 697.4761327576903 402.9312310319153 354.9194333333333 421.048 90.7363 238.10851165458857 390.7413879114949 218.5150550055462 1730.6983333333335 2230.86 299.165 1258.3526053369676 1932.5385698866705 1149.5500855479474 0.5 452.609 138.399;986.476;766.819 90.7363;552.974;421.048 299.165;2230.86;2662.07 1 2 1 29397 CCL11_33230 986.476 986.476 552.974 552.974 2230.86 2230.86 986.476 552.974 2230.86 2 684352;81639 TWF2_10109;ALOX15_8036 452.609 452.609 444.3600434332501 255.89215000000002 255.89215000000002 233.56564297525645 1480.6175 1480.6175 1670.826148799599 138.399;766.819 90.7363;421.048 299.165;2662.07 0 Exp 2,1(0.34);Poly 2,1(0.34);Power,1(0.34) 1.7480789489104795 5.278282403945923 1.5021449327468872 1.9814788103103638 0.24160126088294984 1.7946586608886719 132.4873343185281 1128.6419990148052 85.4742872651023 624.3645794015642 306.738311096874 3154.658355569793 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0009056 3 catabolic process 364 413 25 25 17 18 14 14 54 399 2080 0.87489 0.20132 0.31752 3.39 25682;363131;362282;81687;156275;25315;312495;24296;113902;116599;29657;29221;26760;252898 ppard;pik3r4;pck1;mmp9;ggt7;ephx1;cyp26b1;cyp1a1;ces1d;blvra;arntl;arg1;akr7a3;acox2 PPARD_9536;PIK3R4_9484;PCK1_9439;MMP9_32531;GGT7_33026;EPHX1_8567;CYP26B1_8418;CYP1A1_8415;CES1D_32914;BLVRA_8151;ARNTL_8086;ARG1_33267;AKR7A3_8015;ACOX2_32902 321.01615 101.8582 11.0684 352.1383990491627 332.89431702199164 354.31760888805 200.18952785714285 33.5514 4.18343 239.79104805642663 198.06598014198997 226.98115790692154 779.5828285714285 281.48 17.0564 931.3476611563733 905.7100867083954 1041.049685611154 94.1074;955.628;529.244;728.316;109.609;39.2381;18.1872;12.8863;11.0684;415.991;22.9134;760.927;52.7573;743.353 37.7692;735.228;356.883;443.137;29.3336;18.9587;10.0176;9.13136;4.18343;288.048;11.4115;413.607;12.408;432.537 148.485;1288.97;1021.06;2039.06;346.073;81.6965;36.7271;19.3234;17.0564;720.942;50.1592;2639.93;216.887;2287.79 5 9 5 362282;25315;312495;24296;26760 PCK1_9439;EPHX1_8567;CYP26B1_8418;CYP1A1_8415;AKR7A3_8015 130.46258 39.2381 223.50423922218343 81.479732 12.408 154.00313866114908 275.1388 81.6965 424.11475151662074 529.244;39.2381;18.1872;12.8863;52.7573 356.883;18.9587;10.0176;9.13136;12.408 1021.06;81.6965;36.7271;19.3234;216.887 9 25682;363131;81687;156275;113902;116599;29657;29221;252898 PPARD_9536;PIK3R4_9484;MMP9_32531;GGT7_33026;CES1D_32914;BLVRA_8151;ARNTL_8086;ARG1_33267;ACOX2_32902 426.8792444444445 415.991 375.7968249625956 266.13941444444447 288.048 260.5341327359836 1059.829511111111 720.942 1035.4741697614581 94.1074;955.628;728.316;109.609;11.0684;415.991;22.9134;760.927;743.353 37.7692;735.228;443.137;29.3336;4.18343;288.048;11.4115;413.607;432.537 148.485;1288.97;2039.06;346.073;17.0564;720.942;50.1592;2639.93;2287.79 0 Exp 2,3(0.22);Exp 4,5(0.36);Exp 5,2(0.15);Hill,1(0.08);Linear,2(0.15);Poly 2,1(0.08) 2.128098967527393 39.9004465341568 1.5018656253814697 15.48720932006836 3.671826658390425 1.778877317905426 136.55477612433313 505.477523875667 74.5792953831797 325.799760331106 291.71308872857577 1267.4525684142816 DOWN 0.35714285714285715 0.6428571428571429 0.0 GO:0061041 7 regulation of wound healing 71 74 6 6 3 6 3 3 65 71 2408 0.86678 0.3164 0.44745 4.05 295703;25682;24367 serping1;ppard;fgg SERPING1_32597;PPARD_9536;FGG_8639 56.322766666666666 42.4612 32.3997 33.1069076276135 54.74217602744621 30.616557966532103 24.047466666666665 20.6424 13.7308 12.37566272541933 23.90038195983132 11.16078048511617 115.34230000000001 99.4885 98.0534 28.71138799274608 112.61126259738403 27.55602306424858 32.3997;94.1074;42.4612 13.7308;37.7692;20.6424 99.4885;148.485;98.0534 0 3 0 3 295703;25682;24367 SERPING1_32597;PPARD_9536;FGG_8639 56.322766666666666 42.4612 33.1069076276135 24.047466666666665 20.6424 12.37566272541933 115.34230000000001 99.4885 28.71138799274608 32.3997;94.1074;42.4612 13.7308;37.7692;20.6424 99.4885;148.485;98.0534 0 Exp 4,2(0.67);Exp 5,1(0.34) 2.109508384365333 6.474854469299316 1.7183171510696411 2.8176381587982178 0.5815704785971633 1.9388991594314575 18.858773886222757 93.78675944711057 10.043085943061769 38.05184739027156 82.85230593061738 147.8322940693826 DOWN 0.0 1.0 0.0 GO:0051546 7 keratinocyte migration 1 1 1 1 1 1 1 1 67 0 2479 1.0 0.026698 0.026698 100.0 25682 ppard PPARD_9536 94.1074 94.1074 94.1074 94.1074 37.7692 37.7692 37.7692 37.7692 148.485 148.485 148.485 148.485 0.0 94.1074 0.0 94.1074 94.1074 37.7692 148.485 0 1 0 1 25682 PPARD_9536 94.1074 94.1074 37.7692 37.7692 148.485 148.485 94.1074 37.7692 148.485 0 Exp 5,1(1) 1.9388991594314575 1.9388991594314575 1.9388991594314575 1.9388991594314575 0.0 1.9388991594314575 94.1074 94.1074 37.7692 37.7692 148.485 148.485 DOWN 0.0 1.0 0.0 GO:2001235 7 positive regulation of apoptotic signaling pathway 58 59 4 4 4 3 3 3 65 56 2423 0.92945 0.20735 0.20735 5.08 81687;24854;246142 mmp9;clu;bmf MMP9_32531;CLU_32773;BMF_8152 594.4553333333333 728.316 119.401 424.269027783473 527.2639472710972 422.45041202451284 444.48319999999995 443.137 81.8286 363.3295704702827 376.78270800179314 341.1171255286477 1110.0649999999998 1071.05 220.085 910.1149050119992 1091.6616760058278 984.1941265040638 1.5 831.9825000000001 728.316;935.649;119.401 443.137;808.484;81.8286 2039.06;1071.05;220.085 0 3 0 3 81687;24854;246142 MMP9_32531;CLU_32773;BMF_8152 594.4553333333333 728.316 424.269027783473 444.48319999999995 443.137 363.3295704702827 1110.0649999999998 1071.05 910.1149050119992 728.316;935.649;119.401 443.137;808.484;81.8286 2039.06;1071.05;220.085 0 Linear,1(0.34);Poly 2,2(0.67) 1.722883971046355 5.209591388702393 1.5548590421676636 2.05134654045105 0.27371624671753597 1.6033858060836792 114.34973203009974 1074.5609346365668 33.33708638148528 855.6293136185147 80.17303261175016 2139.9569673882497 DOWN 0.0 1.0 0.0 GO:0045824 7 negative regulation of innate immune response 16 19 2 2 2 2 2 2 66 17 2462 0.98701 0.089736 0.089736 10.53 295703;29221 serping1;arg1 SERPING1_32597;ARG1_33267 396.66335000000004 396.66335000000004 32.3997 515.1465941095263 487.1711027345592 498.9916901237182 213.6689 213.6689 13.7308 282.75517265510814 263.3470606317775 273.8880215995337 1369.7092499999999 1369.7092499999999 99.4885 1796.3634118577245 1685.3180832154644 1740.0297802778757 0.0 32.3997 0.5 396.66335000000004 32.3997;760.927 13.7308;413.607 99.4885;2639.93 0 2 0 2 295703;29221 SERPING1_32597;ARG1_33267 396.66335000000004 396.66335000000004 515.1465941095263 213.6689 213.6689 282.75517265510814 1369.7092499999999 1369.7092499999999 1796.3634118577245 32.3997;760.927 13.7308;413.607 99.4885;2639.93 0 Exp 2,1(0.5);Exp 4,1(0.5) 1.612726770781003 3.231942057609558 1.513624906539917 1.7183171510696411 0.1447392741632629 1.615971028804779 -317.29340399999995 1110.6201039999999 -178.20977599999998 605.5475759999999 -1119.9234199999996 3859.3419199999994 DOWN 0.0 1.0 0.0 GO:0042167 6 heme catabolic process 2 2 2 2 1 2 1 1 67 1 2478 0.9993 0.052694 0.052694 50.0 116599 blvra BLVRA_8151 415.991 415.991 415.991 415.991 288.048 288.048 288.048 288.048 720.942 720.942 720.942 720.942 0.0 415.991 0.0 415.991 415.991 288.048 720.942 0 1 0 1 116599 BLVRA_8151 415.991 415.991 288.048 288.048 720.942 720.942 415.991 288.048 720.942 0 Exp 2,1(1) 1.5686544179916382 1.5686544179916382 1.5686544179916382 1.5686544179916382 0.0 1.5686544179916382 415.991 415.991 288.048 288.048 720.942 720.942 DOWN 0.0 1.0 0.0 GO:0001970 8 positive regulation of activation of membrane attack complex 1 1 1 1 1 1 1 1 67 0 2479 1.0 0.026698 0.026698 100.0 24232 c3 C3_8175 234.759 234.759 234.759 234.759 129.148 129.148 129.148 129.148 694.216 694.216 694.216 694.216 0.0 234.759 0.0 234.759 234.759 129.148 694.216 0 1 0 1 24232 C3_8175 234.759 234.759 129.148 129.148 694.216 694.216 234.759 129.148 694.216 0 Poly 2,1(1) 1.5467612743377686 1.5467612743377686 1.5467612743377686 1.5467612743377686 0.0 1.5467612743377686 234.759 234.759 129.148 129.148 694.216 694.216 DOWN 0.0 1.0 0.0 GO:0035094 5 response to nicotine 34 36 4 4 2 4 2 2 66 34 2445 0.93054 0.24955 0.24955 5.56 81687;170945 mmp9;chrna2 MMP9_32531;CHRNA2_32401 445.89750000000004 445.89750000000004 163.479 399.400072965066 414.3312148940384 396.8974144205507 272.5525 272.5525 101.968 241.24291343063322 253.48604733610614 239.73127465170452 1226.711 1226.711 414.362 1148.8349731802214 1135.9136898395723 1141.636322362451 0.5 445.89750000000004 728.316;163.479 443.137;101.968 2039.06;414.362 0 2 0 2 81687;170945 MMP9_32531;CHRNA2_32401 445.89750000000004 445.89750000000004 399.400072965066 272.5525 272.5525 241.24291343063322 1226.711 1226.711 1148.8349731802214 728.316;163.479 443.137;101.968 2039.06;414.362 0 Linear,1(0.5);Poly 2,1(0.5) 1.92083804788439 3.8499791622161865 1.7986326217651367 2.05134654045105 0.1786957256030349 1.9249895811080933 -107.64275999999995 999.43776 -61.79311999999993 606.89812 -365.4930399999996 2818.91504 DOWN 0.0 1.0 0.0 GO:0007389 3 pattern specification process 49 53 3 3 3 3 3 3 65 50 2429 0.94893 0.16659 0.16659 5.66 25671;312495;24232 smad1;cyp26b1;c3 SMAD1_32578;CYP26B1_8418;C3_8175 91.64783333333332 21.9973 18.1872 123.95254629907096 71.14281930490363 113.3846981184967 48.062486666666665 10.0176 5.02186 70.26652623358105 38.327650935783474 62.96167110265879 270.36306666666667 80.1461 36.7271 367.7088307502328 201.17520068910412 342.049996026952 1.5 128.37815 21.9973;18.1872;234.759 5.02186;10.0176;129.148 80.1461;36.7271;694.216 1 2 1 312495 CYP26B1_8418 18.1872 18.1872 10.0176 10.0176 36.7271 36.7271 18.1872 10.0176 36.7271 2 25671;24232 SMAD1_32578;C3_8175 128.37815 128.37815 150.44524084677784 67.08493 67.08493 87.77043531651077 387.18105 387.18105 434.21299041254514 21.9973;234.759 5.02186;129.148 80.1461;694.216 0 Exp 4,2(0.67);Poly 2,1(0.34) 1.7624513225584746 5.33031165599823 1.5467612743377686 2.090334892272949 0.28125461044193406 1.6932154893875122 -48.61767717278269 231.91334383944934 -31.45157309185005 127.5765464251834 -145.7386464707502 686.4647798040835 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0033273 5 response to vitamin 73 78 13 13 11 11 10 10 58 68 2411 1.0 2.797E-5 2.797E-5 12.82 116669;25682;81687;24426;312495;24296;245920;29221;24646;170913 vwf;ppard;mmp9;gstp1;cyp26b1;cyp1a1;cxcl10;arg1;abcb1b;abcb1a VWF_32396;PPARD_9536;MMP9_32531;GSTP1_8762;CYP26B1_8418;CYP1A1_8415;CXCL10_8408;ARG1_33267;ABCB1B_7939;ABCB1A_7938 254.71675 57.45075 12.8863 327.19137334577437 218.27067061057758 313.4995398180749 142.82890700000002 23.8934 4.11644 188.45301812676627 122.89655789881034 182.938163414851 854.7384599999999 121.28150000000001 19.3234 1055.4944404030466 766.3139824781422 1026.2821179948594 2.5 18.931800000000003 6.5 438.755 19.6764;94.1074;728.316;14.7631;18.1872;12.8863;670.528;760.927;20.7941;206.982 4.11644;37.7692;443.137;9.42992;10.0176;9.13136;374.802;413.607;8.25355;118.025 94.078;148.485;2039.06;25.7196;36.7271;19.3234;1955.3;2639.93;57.2115;1531.55 3 7 3 24426;312495;24296 GSTP1_8762;CYP26B1_8418;CYP1A1_8415 15.278866666666667 14.7631 2.6878237746052673 9.526293333333333 9.42992 0.45091152007169494 27.2567 25.7196 8.80307904826488 14.7631;18.1872;12.8863 9.42992;10.0176;9.13136 25.7196;36.7271;19.3234 7 116669;25682;81687;245920;29221;24646;170913 VWF_32396;PPARD_9536;MMP9_32531;CXCL10_8408;ARG1_33267;ABCB1B_7939;ABCB1A_7938 357.3329857142857 206.982 345.8735707314473 199.95859857142858 118.025 201.4427469046595 1209.3735 1531.55 1087.192206598071 19.6764;94.1074;728.316;670.528;760.927;20.7941;206.982 4.11644;37.7692;443.137;374.802;413.607;8.25355;118.025 94.078;148.485;2039.06;1955.3;2639.93;57.2115;1531.55 0 Exp 2,2(0.2);Exp 4,3(0.3);Exp 5,1(0.1);Hill,2(0.2);Linear,1(0.1);Poly 2,1(0.1) 2.814151146351378 38.633179783821106 1.513624906539917 15.48720932006836 4.3124963722243255 2.0708407163619995 51.921435775893855 457.5120642241062 26.024516234138417 259.6332977658616 200.53622809357807 1508.9406919064218 DOWN 0.3 0.7 0.0 GO:0045471 5 response to ethanol 109 117 7 6 5 4 3 3 65 114 2365 0.6187 0.61282 1.0 2.56 24314;81687;24426 nqo1;mmp9;gstp1 NQO1_33055;MMP9_32531;GSTP1_8762 256.25346666666667 25.6813 14.7631 408.8545931081408 299.4705039038339 422.2405043274933 153.43545333333333 9.42992 7.73944 250.89032272379845 178.96495972690667 260.0875728204016 716.9669 86.1211 25.7196 1145.3644437912633 841.5312659158545 1179.307419197246 25.6813;728.316;14.7631 7.73944;443.137;9.42992 86.1211;2039.06;25.7196 2 1 2 24314;24426 NQO1_33055;GSTP1_8762 20.2222 20.2222 7.720333258350962 8.584679999999999 8.584679999999999 1.1953498714602508 55.92035 55.92035 42.710310243839245 25.6813;14.7631 7.73944;9.42992 86.1211;25.7196 1 81687 MMP9_32531 728.316 728.316 443.137 443.137 2039.06 2039.06 728.316 443.137 2039.06 0 Exp 4,1(0.34);Hill,1(0.34);Linear,1(0.34) 2.505351843024395 7.752313613891602 2.05134654045105 3.5281898975372314 0.819853172481001 2.1727771759033203 -206.40905973851733 718.9159930718508 -130.47367357551462 437.3445802421813 -579.1349810884994 2013.0687810884992 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0048584 5 positive regulation of response to stimulus 502 537 37 36 25 24 19 19 49 518 1961 0.93626 0.10711 0.17437 3.54 688621;24832;295703;25682;316351;81687;24367;29243;245920;84032;24854;29397;24232;246142;29657;29221;81639;252898;170913 tslp;thy1;serping1;ppard;npas2;mmp9;fgg;f10;cxcl10;col3a1;clu;ccl11;c3;bmf;arntl;arg1;alox15;acox2;abcb1a TSLP_32811;THY1_33010;SERPING1_32597;PPARD_9536;NPAS2_9350;MMP9_32531;FGG_8639;F10_8585;CXCL10_8408;COL3A1_8354;CLU_32773;CCL11_33230;C3_8175;BMF_8152;ARNTL_8086;ARG1_33267;ALOX15_8036;ACOX2_32902;ABCB1A_7938 369.87618421052656 212.603 5.72311E-12 353.44388698035243 372.3605623339401 351.4748769919607 224.88988947368455 119.81 5.72311E-12 234.0286524354651 226.70460713835487 229.49863806009787 1052.9383421052635 694.216 5.72313E-12 996.5111926158786 1058.1469455096872 1007.8566237926415 344.675;5.72311E-12;32.3997;94.1074;21.0878;728.316;42.4612;104.19;670.528;212.603;935.649;986.476;234.759;119.401;22.9134;760.927;766.819;743.353;206.982 244.2;5.72311E-12;13.7308;37.7692;11.3305;443.137;20.6424;38.4229;374.802;119.81;808.484;552.974;129.148;81.8286;11.4115;413.607;421.048;432.537;118.025 560.435;5.72313E-12;99.4885;148.485;43.5624;2039.06;98.0534;163.044;1955.3;1510.69;1071.05;2230.86;694.216;220.085;50.1592;2639.93;2662.07;2287.79;1531.55 1 18 1 29397 CCL11_33230 986.476 986.476 552.974 552.974 2230.86 2230.86 986.476 552.974 2230.86 18 688621;24832;295703;25682;316351;81687;24367;29243;245920;84032;24854;24232;246142;29657;29221;81639;252898;170913 TSLP_32811;THY1_33010;SERPING1_32597;PPARD_9536;NPAS2_9350;MMP9_32531;FGG_8639;F10_8585;CXCL10_8408;COL3A1_8354;CLU_32773;C3_8175;BMF_8152;ARNTL_8086;ARG1_33267;ALOX15_8036;ACOX2_32902;ABCB1A_7938 335.6206388888892 209.79250000000002 329.64233439408946 206.66299444444476 118.9175 226.51194549340283 987.4982500000003 627.3254999999999 982.4950019999823 344.675;5.72311E-12;32.3997;94.1074;21.0878;728.316;42.4612;104.19;670.528;212.603;935.649;234.759;119.401;22.9134;760.927;766.819;743.353;206.982 244.2;5.72311E-12;13.7308;37.7692;11.3305;443.137;20.6424;38.4229;374.802;119.81;808.484;129.148;81.8286;11.4115;413.607;421.048;432.537;118.025 560.435;5.72313E-12;99.4885;148.485;43.5624;2039.06;98.0534;163.044;1955.3;1510.69;1071.05;694.216;220.085;50.1592;2639.93;2662.07;2287.79;1531.55 0 Exp 2,5(0.27);Exp 4,4(0.22);Exp 5,2(0.11);Hill,1(0.06);Linear,1(0.06);Poly 2,5(0.27);Power,1(0.06) 1.8704634540233485 36.71370542049408 1.5021449327468872 3.442979335784912 0.5636850647921822 1.7183171510696411 210.9484303317502 528.803938089303 119.65777358505163 330.1220053623174 604.8522628394308 1501.0244213710967 DOWN 0.05263157894736842 0.9473684210526315 0.0 GO:0051186 4 cofactor metabolic process 111 126 11 11 8 6 5 5 63 121 2358 0.8831 0.24432 0.38479 3.97 24426;156275;25283;24296;116599 gstp1;ggt7;gclc;cyp1a1;blvra GSTP1_8762;GGT7_33026;GCLC_8699;CYP1A1_8415;BLVRA_8151 136.98988 109.609 12.8863 165.04575479183643 123.43229111508084 129.18679283556443 75.171736 29.3336 9.13136 119.73276195656257 56.450669317412554 93.10747458031427 301.8534 346.073 19.3234 292.7270035920499 309.2648945656261 244.13460800008338 14.7631;109.609;131.7;12.8863;415.991 9.42992;29.3336;39.9158;9.13136;288.048 25.7196;346.073;397.209;19.3234;720.942 2 3 2 24426;24296 GSTP1_8762;CYP1A1_8415 13.8247 13.8247 1.3270980069309275 9.28064 9.28064 0.2111138005910525 22.5215 22.5215 4.522796393825391 14.7631;12.8863 9.42992;9.13136 25.7196;19.3234 3 156275;25283;116599 GGT7_33026;GCLC_8699;BLVRA_8151 219.1 131.7 170.8699870691164 119.09913333333333 39.9158 146.40964927276255 488.07466666666664 397.209 203.28334615588514 109.609;131.7;415.991 29.3336;39.9158;288.048 346.073;397.209;720.942 0 Exp 2,1(0.2);Exp 4,3(0.6);Hill,1(0.2) 3.18314960006885 24.48952865600586 1.5686544179916382 15.48720932006836 5.967461388972399 1.9746891260147095 -7.679102628024708 281.65886262802474 -29.77865718852047 180.12212918852046 45.26686827839376 558.4399317216063 DOWN 0.4 0.6 0.0 GO:0030030 5 cell projection organization 158 167 8 8 2 7 2 2 66 165 2314 0.16508 0.94491 0.31925 1.2 338475;24854 nrep;clu NREP_9364;CLU_32773 498.596 498.596 61.543 618.0862800758483 472.55835142305835 616.9884369509426 417.07795000000004 417.07795000000004 25.6719 553.5317443048818 393.75974103955616 552.5485627661693 609.919 609.919 148.788 652.1377142306676 582.4468926676315 650.9793890434916 61.543;935.649 25.6719;808.484 148.788;1071.05 0 2 0 2 338475;24854 NREP_9364;CLU_32773 498.596 498.596 618.0862800758483 417.07795000000004 417.07795000000004 553.5317443048818 609.919 609.919 652.1377142306676 61.543;935.649 25.6719;808.484 148.788;1071.05 0 Exp 4,1(0.5);Poly 2,1(0.5) 1.6666001928255285 3.3412307500839233 1.5548590421676636 1.7863717079162598 0.16370417588140693 1.6706153750419617 -358.02788 1355.21988 -350.07790799999987 1184.233808 -293.89775999999983 1513.7357599999998 DOWN 0.0 1.0 0.0 GO:0001869 8 negative regulation of complement activation, lectin pathway 1 2 1 1 1 1 1 1 67 1 2478 0.9993 0.052694 0.052694 50.0 295703 serping1 SERPING1_32597 32.3997 32.3997 32.3997 32.3997 13.7308 13.7308 13.7308 13.730800000000002 99.4885 99.4885 99.4885 99.4885 0.0 32.3997 0.0 32.3997 32.3997 13.7308 99.4885 0 1 0 1 295703 SERPING1_32597 32.3997 32.3997 13.7308 13.7308 99.4885 99.4885 32.3997 13.7308 99.4885 0 Exp 4,1(1) 1.7183171510696411 1.7183171510696411 1.7183171510696411 1.7183171510696411 0.0 1.7183171510696411 32.3997 32.3997 13.7308 13.7308 99.4885 99.4885 DOWN 0.0 1.0 0.0 GO:0007584 4 response to nutrient 144 154 16 16 13 14 12 12 56 142 2337 0.99985 5.8852E-4 5.8852E-4 7.79 116669;25682;24314;81687;24426;25283;312495;24296;245920;29221;24646;170913 vwf;ppard;nqo1;mmp9;gstp1;gclc;cyp26b1;cyp1a1;cxcl10;arg1;abcb1b;abcb1a VWF_32396;PPARD_9536;NQO1_33055;MMP9_32531;GSTP1_8762;GCLC_8699;CYP26B1_8418;CYP1A1_8415;CXCL10_8408;ARG1_33267;ABCB1B_7939;ABCB1A_7938 225.37906666666666 59.89435 12.8863 304.6234210693451 188.41695679785707 281.49018759913116 122.99535916666667 23.8934 4.11644 176.77687441842863 101.28771215257332 165.6548715713903 752.5595583333334 121.28150000000001 19.3234 986.3355569990666 653.2489571578051 927.440153625282 6.5 112.90369999999999 19.6764;94.1074;25.6813;728.316;14.7631;131.7;18.1872;12.8863;670.528;760.927;20.7941;206.982 4.11644;37.7692;7.73944;443.137;9.42992;39.9158;10.0176;9.13136;374.802;413.607;8.25355;118.025 94.078;148.485;86.1211;2039.06;25.7196;397.209;36.7271;19.3234;1955.3;2639.93;57.2115;1531.55 4 8 4 24314;24426;312495;24296 NQO1_33055;GSTP1_8762;CYP26B1_8418;CYP1A1_8415 17.879475 16.47515 5.645256348696673 9.07958 9.28064 0.9663118930586894 41.9728 31.22335 30.297148336545906 25.6813;14.7631;18.1872;12.8863 7.73944;9.42992;10.0176;9.13136 86.1211;25.7196;36.7271;19.3234 8 116669;25682;81687;25283;245920;29221;24646;170913 VWF_32396;PPARD_9536;MMP9_32531;GCLC_8699;CXCL10_8408;ARG1_33267;ABCB1B_7939;ABCB1A_7938 329.1288625 169.341 330.0038149769049 179.95324875 78.9704 194.8945014564551 1107.8529375 964.3795 1046.701017667497 19.6764;94.1074;728.316;131.7;670.528;760.927;20.7941;206.982 4.11644;37.7692;443.137;39.9158;374.802;413.607;8.25355;118.025 94.078;148.485;2039.06;397.209;1955.3;2639.93;57.2115;1531.55 0 Exp 2,2(0.17);Exp 4,3(0.25);Exp 5,1(0.09);Hill,4(0.34);Linear,1(0.09);Poly 2,1(0.09) 2.6740263137162215 42.780646085739136 1.513624906539917 15.48720932006836 3.962734751742649 2.0708407163619995 53.02214079393252 397.73599253940074 22.97442665532583 223.0162916780075 194.4876809755168 1310.6314356911494 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0033762 6 response to glucagon 17 18 4 4 4 4 4 4 64 14 2465 0.99992 0.0010726 0.0010726 22.22 362282;114494;29221;170913 pck1;ccna2;arg1;abcb1a PCK1_9439;CCNA2_8221;ARG1_33267;ABCB1A_7938 377.88425 368.113 14.384 332.15033396177193 326.14838284888395 348.0782503144456 223.3517475 237.454 4.89199 193.94676751104078 182.79412702478456 193.87300608084885 1312.6976 1276.3049999999998 58.2504 1075.1949410714815 1362.6656470210376 1154.455094432961 0.0 14.384 0.5 110.68299999999999 529.244;14.384;760.927;206.982 356.883;4.89199;413.607;118.025 1021.06;58.2504;2639.93;1531.55 1 3 1 362282 PCK1_9439 529.244 529.244 356.883 356.883 1021.06 1021.06 529.244 356.883 1021.06 3 114494;29221;170913 CCNA2_8221;ARG1_33267;ABCB1A_7938 327.431 206.982 387.5726821036282 178.84133 118.025 211.0354457095459 1409.910133333333 1531.55 1295.1311061572312 14.384;760.927;206.982 4.89199;413.607;118.025 58.2504;2639.93;1531.55 0 Exp 2,1(0.25);Exp 4,1(0.25);Linear,1(0.25);Poly 2,1(0.25) 1.6542831795281376 6.639309048652649 1.513624906539917 1.8874764442443848 0.15982739083601896 1.6191038489341736 52.37692271746346 703.3915772825366 33.28391533918008 413.41957966082 259.0065577499479 2366.388642250052 DOWN 0.25 0.75 0.0 GO:0071404 5 cellular response to low-density lipoprotein particle stimulus 17 17 2 2 2 2 2 2 66 15 2464 0.99053 0.073823 0.073823 11.76 81687;113902 mmp9;ces1d MMP9_32531;CES1D_32914 369.6922 369.6922 11.0684 507.1706417497764 585.3958140221403 405.1739893532841 223.660215 223.660215 4.18343 310.3870459730439 355.6702369741697 247.96537360008736 1028.0582 1028.0582 17.0564 1429.7724571436113 1636.1515335793358 1142.2321456338118 0.0 11.0684 0.5 369.6922 728.316;11.0684 443.137;4.18343 2039.06;17.0564 0 2 0 2 81687;113902 MMP9_32531;CES1D_32914 369.6922 369.6922 507.1706417497764 223.660215 223.660215 310.3870459730439 1028.0582 1028.0582 1429.7724571436113 728.316;11.0684 443.137;4.18343 2039.06;17.0564 0 Exp 5,1(0.5);Linear,1(0.5) 1.8268762134111933 3.678315281867981 1.6269687414169312 2.05134654045105 0.30008041948204717 1.8391576409339905 -333.210448 1072.594848 -206.5142836 653.8347136 -953.5053279999997 3009.6217279999996 DOWN 0.0 1.0 0.0 GO:0009314 4 response to radiation 159 166 19 19 16 13 11 11 57 155 2324 0.99884 0.003811 0.003811 6.63 116669;360243;300795;81687;361921;245920;84032;24854;246142;25612;24646 vwf;top2a;pclaf;mmp9;ect2;cxcl10;col3a1;clu;bmf;asns;abcb1b VWF_32396;TOP2A_10059;NS5ATP9_9367;MMP9_32531;ECT2_8523;CXCL10_8408;COL3A1_8354;CLU_32773;BMF_8152;ASNS_8091;ABCB1B_7939 298.79390909090904 191.145 10.0162 326.06767682108716 218.62731120520047 302.56583449307817 193.77213090909092 113.564 3.29405 251.79065004823553 141.2023572467851 228.86031872902163 765.1126363636365 510.267 37.7305 761.2939019964 543.8465680512489 703.1477523150534 7.5 481.372 19.6764;86.3883;292.216;728.316;10.0162;670.528;212.603;935.649;119.401;191.145;20.7941 4.11644;26.6888;147.515;443.137;3.29405;374.802;119.81;808.484;81.8286;113.564;8.25355 94.078;262.273;658.494;2039.06;37.7305;1955.3;1510.69;1071.05;220.085;510.267;57.2115 0 11 0 11 116669;360243;300795;81687;361921;245920;84032;24854;246142;25612;24646 VWF_32396;TOP2A_10059;NS5ATP9_9367;MMP9_32531;ECT2_8523;CXCL10_8408;COL3A1_8354;CLU_32773;BMF_8152;ASNS_8091;ABCB1B_7939 298.79390909090904 191.145 326.06767682108716 193.77213090909092 113.564 251.79065004823553 765.1126363636365 510.267 761.2939019964 19.6764;86.3883;292.216;728.316;10.0162;670.528;212.603;935.649;119.401;191.145;20.7941 4.11644;26.6888;147.515;443.137;3.29405;374.802;119.81;808.484;81.8286;113.564;8.25355 94.078;262.273;658.494;2039.06;37.7305;1955.3;1510.69;1071.05;220.085;510.267;57.2115 0 Exp 2,2(0.19);Exp 4,2(0.19);Hill,2(0.19);Linear,1(0.1);Poly 2,4(0.37) 1.9873385646494772 24.026376485824585 1.5548590421676636 6.191005229949951 1.3421002942913414 1.805381178855896 106.10022591402873 491.48759226778947 44.973365510711716 342.5708963074701 315.2166902644541 1215.0085824628186 DOWN 0.0 1.0 0.0 GO:0000413 9 protein peptidyl-prolyl isomerization 8 8 1 1 1 1 1 1 67 7 2472 0.98227 0.1949 0.1949 12.5 291463 ppic PPIC_9541 628.678 628.678 628.678 628.678 389.239 389.239 389.239 389.239 1509.86 1509.86 1509.86 1509.86 0.0 628.678 0.0 628.678 628.678 389.239 1509.86 0 1 0 1 291463 PPIC_9541 628.678 628.678 389.239 389.239 1509.86 1509.86 628.678 389.239 1509.86 0 Exp 2,1(1) 2.13726544380188 2.13726544380188 2.13726544380188 2.13726544380188 0.0 2.13726544380188 628.678 628.678 389.239 389.239 1509.86 1509.86 DOWN 0.0 1.0 0.0 GO:0036345 5 platelet maturation 1 1 1 1 1 1 1 1 67 0 2479 1.0 0.026698 0.026698 100.0 24367 fgg FGG_8639 42.4612 42.4612 42.4612 42.4612 20.6424 20.6424 20.6424 20.6424 98.0534 98.0534 98.0534 98.0534 0.0 42.4612 0.0 42.4612 42.4612 20.6424 98.0534 0 1 0 1 24367 FGG_8639 42.4612 42.4612 20.6424 20.6424 98.0534 98.0534 42.4612 20.6424 98.0534 0 Exp 4,1(1) 2.8176381587982178 2.8176381587982178 2.8176381587982178 2.8176381587982178 0.0 2.8176381587982178 42.4612 42.4612 20.6424 20.6424 98.0534 98.0534 DOWN 0.0 1.0 0.0 GO:0072593 4 reactive oxygen species metabolic process 40 44 4 4 3 2 2 2 66 42 2437 0.88892 0.32953 0.32953 4.55 24314;24296 nqo1;cyp1a1 NQO1_33055;CYP1A1_8415 19.2838 19.2838 12.8863 9.047431265281876 21.61751721079449 8.423986019698932 8.435400000000001 8.435400000000001 7.73944 0.9842360708691725 8.18152366861672 0.9164138038717873 52.72225 52.72225 19.3234 47.23310663766464 64.90567650500094 43.9783423953141 25.6813;12.8863 7.73944;9.13136 86.1211;19.3234 2 0 2 24314;24296 NQO1_33055;CYP1A1_8415 19.2838 19.2838 9.047431265281876 8.435400000000001 8.435400000000001 0.9842360708691725 52.72225 52.72225 47.23310663766464 25.6813;12.8863 7.73944;9.13136 86.1211;19.3234 0 0 Exp 4,1(0.5);Hill,1(0.5) 5.800883978246911 17.65998649597168 2.1727771759033203 15.48720932006836 9.414725256787243 8.82999324798584 6.7447 31.822899999999997 7.071318400000001 9.799481600000002 -12.739495999999988 118.183996 UP 1.0 0.0 0.0 GO:0071230 6 cellular response to amino acid stimulus 36 39 4 4 3 4 3 3 65 36 2443 0.98107 0.08408 0.08408 7.69 25283;84032;170913 gclc;col3a1;abcb1a GCLC_8699;COL3A1_8354;ABCB1A_7938 183.76166666666668 206.982 131.7 45.17423781684997 171.00482527186225 47.11749384946893 92.5836 118.025 39.9158 45.620383863794906 80.10967932714092 48.13495945823974 1146.483 1510.69 397.209 648.9741367781925 974.1388678636157 690.8885877816567 0.5 169.341 131.7;212.603;206.982 39.9158;119.81;118.025 397.209;1510.69;1531.55 0 3 0 3 25283;84032;170913 GCLC_8699;COL3A1_8354;ABCB1A_7938 183.76166666666668 206.982 45.17423781684997 92.5836 118.025 45.620383863794906 1146.483 1510.69 648.9741367781925 131.7;212.603;206.982 39.9158;119.81;118.025 397.209;1510.69;1531.55 0 Hill,1(0.34);Poly 2,2(0.67) 1.8183197057548994 5.475151062011719 1.6129854917526245 1.9746891260147095 0.18875948271976775 1.8874764442443848 132.6422042732372 234.8811290600961 40.959275827579724 144.2079241724203 412.0996305706509 1880.866369429349 DOWN 0.0 1.0 0.0 GO:0090200 8 positive regulation of release of cytochrome c from mitochondria 14 14 2 2 2 2 2 2 66 12 2467 0.99463 0.051979 0.051979 14.29 81687;246142 mmp9;bmf MMP9_32531;BMF_8152 423.8585 423.8585 119.401 430.56792566620675 413.0965047680505 430.29884676786554 262.4828 262.4828 81.8286 255.48361973966158 256.09701663440165 255.3239579375491 1129.5725 1129.5725 220.085 1286.2095573088004 1097.4238416863843 1285.4057541686084 0.0 119.401 0.5 423.8585 728.316;119.401 443.137;81.8286 2039.06;220.085 0 2 0 2 81687;246142 MMP9_32531;BMF_8152 423.8585 423.8585 430.56792566620675 262.4828 262.4828 255.48361973966158 1129.5725 1129.5725 1286.2095573088004 728.316;119.401 443.137;81.8286 2039.06;220.085 0 Linear,1(0.5);Poly 2,1(0.5) 1.8135875844077873 3.654732346534729 1.6033858060836792 2.05134654045105 0.31675607297647346 1.8273661732673645 -172.87820000000005 1020.5952 -91.59943199999998 616.565032 -653.0229999999997 2912.1679999999997 DOWN 0.0 1.0 0.0 GO:0031400 8 negative regulation of protein modification process 161 172 12 11 6 4 3 3 65 169 2310 0.31442 0.8497 0.62356 1.74 24832;24426;25283 thy1;gstp1;gclc THY1_33010;GSTP1_8762;GCLC_8699 48.82103333333524 14.7631 5.72311E-12 72.15386072278497 77.93956608048602 75.78308259845313 16.44857333333524 9.42992 5.72311E-12 20.86297901475336 24.659271814530676 21.77297697283226 140.9762000000019 25.7196 5.72313E-12 222.27642768165768 231.13043204900345 233.62122340632544 5.72311E-12;14.7631;131.7 5.72311E-12;9.42992;39.9158 5.72313E-12;25.7196;397.209 1 2 1 24426 GSTP1_8762 14.7631 14.7631 9.42992 9.42992 25.7196 25.7196 14.7631 9.42992 25.7196 2 24832;25283 THY1_33010;GCLC_8699 65.85000000000285 65.85000000000285 93.12596308226425 19.95790000000286 19.95790000000286 28.224732856481946 198.60450000000287 198.60450000000287 280.8691774483233 5.72311E-12;131.7 5.72311E-12;39.9158 5.72313E-12;397.209 0 Exp 4,1(0.34);Hill,2(0.67) 2.350193919959772 7.366083025932312 1.863204002380371 3.5281898975372314 0.9307677485982675 1.9746891260147095 -32.82874645295129 130.47081311962177 -7.160109905184878 40.05725657185536 -110.55325649876448 392.5056564987683 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0043604 6 amide biosynthetic process 50 60 4 4 4 4 4 4 64 56 2423 0.97948 0.074126 0.074126 6.67 156275;25283;25612;29221 ggt7;gclc;asns;arg1 GGT7_33026;GCLC_8699;ASNS_8091;ARG1_33267 298.34524999999996 161.4225 109.609 310.304033943459 281.40114196113797 293.4824366994046 149.1051 76.73989999999999 29.3336 180.27011246049636 139.8246163072887 170.701927392126 973.36975 453.738 346.073 1113.1561205776945 907.6244262523571 1055.395824750299 2.0 191.145 109.609;131.7;191.145;760.927 29.3336;39.9158;113.564;413.607 346.073;397.209;510.267;2639.93 0 4 0 4 156275;25283;25612;29221 GGT7_33026;GCLC_8699;ASNS_8091;ARG1_33267 298.34524999999996 161.4225 310.304033943459 149.1051 76.73989999999999 180.27011246049636 973.36975 453.738 1113.1561205776945 109.609;131.7;191.145;760.927 29.3336;39.9158;113.564;413.607 346.073;397.209;510.267;2639.93 0 Exp 2,1(0.25);Exp 4,1(0.25);Hill,1(0.25);Poly 2,1(0.25) 1.7966149408668857 7.224481105804443 1.513624906539917 1.9746891260147095 0.20777476669461029 1.8680835366249084 -5.752703264589854 602.4432032645898 -27.55961021128644 325.7698102112864 -117.52324816614089 2064.2627481661407 DOWN 0.0 1.0 0.0 GO:0071900 8 regulation of protein serine/threonine kinase activity 142 154 11 10 6 4 3 3 65 151 2328 0.40261 0.79072 0.79631 1.95 24832;24426;114494 thy1;gstp1;ccna2 THY1_33010;GSTP1_8762;CCNA2_8221 9.715700000001908 14.384 5.72311E-12 8.416177818341556 10.521074459582294 7.946037021535626 4.773970000001907 4.89199 5.72311E-12 4.71606767782998 4.721191672242379 4.2248853870709056 27.99000000000191 25.7196 5.72313E-12 29.19149383227655 33.77562776735618 30.242809167701356 5.72311E-12;14.7631;14.384 5.72311E-12;9.42992;4.89199 5.72313E-12;25.7196;58.2504 1 2 1 24426 GSTP1_8762 14.7631 14.7631 9.42992 9.42992 25.7196 25.7196 14.7631 9.42992 25.7196 2 24832;114494 THY1_33010;CCNA2_8221 7.192000000002862 7.192000000002862 10.171023940583254 2.4459950000028616 2.4459950000028616 3.4591593024927314 29.12520000000286 29.12520000000286 41.18925284682482 5.72311E-12;14.384 5.72311E-12;4.89199 5.72313E-12;58.2504 0 Exp 4,2(0.67);Hill,1(0.34) 2.203172042260568 7.018189072608948 1.6267951726913452 3.5281898975372314 1.0362889771920114 1.863204002380371 0.19189824322609006 19.239501756777727 -0.5627629688888938 10.110702968892708 -5.04328497133794 61.02328497134175 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0051726 5 regulation of cell cycle 252 268 21 21 16 12 10 10 58 258 2221 0.90508 0.17157 0.23265 3.73 315852;360243;363131;300795;291234;361921;24296;114494;25612;29657 ttk;top2a;pik3r4;pclaf;mki67;ect2;cyp1a1;ccna2;asns;arntl TTK_32727;TOP2A_10059;PIK3R4_9484;NS5ATP9_9367;MKI67_9232;ECT2_8523;CYP1A1_8415;CCNA2_8221;ASNS_8091;ARNTL_8086 234.48593 54.65085 10.0162 339.59840260325484 172.18028795907603 276.4232875071117 150.51762399999998 19.050150000000002 3.29405 247.01400965150404 103.12181557795978 192.02489430427713 506.97369 169.2262 19.3234 692.1421747957415 423.82411873465924 636.851524024065 737.351;86.3883;955.628;292.216;21.9311;10.0162;12.8863;14.384;191.145;22.9134 446.625;26.6888;735.228;147.515;6.82654;3.29405;9.13136;4.89199;113.564;11.4115 2108.09;262.273;1288.97;658.494;76.1794;37.7305;19.3234;58.2504;510.267;50.1592 1 9 1 24296 CYP1A1_8415 12.8863 12.8863 9.13136 9.13136 19.3234 19.3234 12.8863 9.13136 19.3234 9 315852;360243;363131;300795;291234;361921;114494;25612;29657 TTK_32727;TOP2A_10059;PIK3R4_9484;NS5ATP9_9367;MKI67_9232;ECT2_8523;CCNA2_8221;ASNS_8091;ARNTL_8086 259.1081111111111 86.3883 350.60323251789714 166.22720888888887 26.6888 256.64471880225574 561.1570555555556 262.273 711.2771762747789 737.351;86.3883;955.628;292.216;21.9311;10.0162;14.384;191.145;22.9134 446.625;26.6888;735.228;147.515;6.82654;3.29405;4.89199;113.564;11.4115 2108.09;262.273;1288.97;658.494;76.1794;37.7305;58.2504;510.267;50.1592 0 Exp 2,1(0.1);Exp 4,6(0.6);Linear,1(0.1);Poly 2,2(0.2) 2.271065174561989 32.559746623039246 1.5018656253814697 15.48720932006836 4.3349775057663145 1.735765516757965 24.000659371696628 444.97120062830345 -2.583245356035235 303.6184933560353 77.97952554468162 935.9678544553183 DOWN 0.1 0.9 0.0 GO:0043200 5 response to amino acid 78 82 9 9 7 9 7 7 61 75 2404 0.99874 0.0054892 0.0054892 8.54 362282;24426;25283;84032;25612;29221;170913 pck1;gstp1;gclc;col3a1;asns;arg1;abcb1a PCK1_9439;GSTP1_8762;GCLC_8699;COL3A1_8354;ASNS_8091;ARG1_33267;ABCB1A_7938 292.4805857142857 206.982 14.7631 258.9838134601622 264.8115216376327 248.52925321536773 167.3192457142857 118.025 9.42992 155.6328101306961 141.80053592468767 143.63251104771325 1090.9179428571429 1021.06 25.7196 887.6672424169371 1054.258671411813 913.8843726480073 3.5 209.79250000000002 529.244;14.7631;131.7;212.603;191.145;760.927;206.982 356.883;9.42992;39.9158;119.81;113.564;413.607;118.025 1021.06;25.7196;397.209;1510.69;510.267;2639.93;1531.55 2 5 2 362282;24426 PCK1_9439;GSTP1_8762 272.00355 272.00355 363.7929331809581 183.15645999999998 183.15645999999998 245.686429012152 523.3897999999999 523.3897999999999 703.8119464289307 529.244;14.7631 356.883;9.42992 1021.06;25.7196 5 25283;84032;25612;29221;170913 GCLC_8699;COL3A1_8354;ASNS_8091;ARG1_33267;ABCB1A_7938 300.6714 206.982 259.2857161497718 160.98436 118.025 145.14244687253964 1317.9292 1510.69 912.4856989847561 131.7;212.603;191.145;760.927;206.982 39.9158;119.81;113.564;413.607;118.025 397.209;1510.69;510.267;2639.93;1531.55 0 Exp 2,1(0.15);Exp 4,1(0.15);Hill,1(0.15);Linear,1(0.15);Poly 2,3(0.43) 1.9119631344558052 13.933759570121765 1.513624906539917 3.5281898975372314 0.6980039873750502 1.805381178855896 100.6226917924009 484.3384796361705 52.02484650885816 282.6136449197133 433.3248471413067 1748.511038572979 DOWN 0.2857142857142857 0.7142857142857143 0.0 GO:0014823 3 response to activity 61 66 9 8 3 7 3 3 65 63 2416 0.90255 0.2574 0.2574 4.55 25682;362282;25283 ppard;pck1;gclc PPARD_9536;PCK1_9439;GCLC_8699 251.68380000000002 131.7 94.1074 241.1079620454704 155.93340085563048 143.50658102644923 144.856 39.9158 37.7692 183.62390508765463 67.20340815024291 110.23223270707432 522.2513333333333 397.209 148.485 449.52582962532125 380.9224915524617 278.4900321711457 94.1074;529.244;131.7 37.7692;356.883;39.9158 148.485;1021.06;397.209 1 2 1 362282 PCK1_9439 529.244 529.244 356.883 356.883 1021.06 1021.06 529.244 356.883 1021.06 2 25682;25283 PPARD_9536;GCLC_8699 112.90369999999999 112.90369999999999 26.581982382433427 38.8425 38.8425 1.5178754164949093 272.847 272.847 175.87442704384296 94.1074;131.7 37.7692;39.9158 148.485;397.209 0 Exp 5,1(0.34);Hill,1(0.34);Linear,1(0.34) 1.834088258802237 5.525000810623169 1.611412525177002 1.9746891260147095 0.20020751985524957 1.9388991594314575 -21.1555437098003 524.5231437098003 -62.93400962273512 352.6460096227351 13.564970199270022 1030.9376964673968 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0006796 5 phosphate-containing compound metabolic process 383 419 22 22 17 14 10 10 58 409 2070 0.42335 0.70327 0.86814 2.39 684352;315852;24832;25671;25682;363131;362282;114494;29397;81639 twf2;ttk;thy1;smad1;ppard;pik3r4;pck1;ccna2;ccl11;alox15 TWF2_10109;TTK_32727;THY1_33010;SMAD1_32578;PPARD_9536;PIK3R4_9484;PCK1_9439;CCNA2_8221;CCL11_33230;ALOX15_8036 424.44057000000055 333.8215 5.72311E-12 411.6849054580182 434.06443284504786 421.8776344849445 265.1177350000006 223.80964999999998 5.72311E-12 270.2459469144201 257.3792321849828 259.27841225948333 989.7096500000005 660.1125 5.72313E-12 1029.4289540519344 1112.3567608970798 1134.4888103811638 138.399;737.351;5.72311E-12;21.9973;94.1074;955.628;529.244;14.384;986.476;766.819 90.7363;446.625;5.72311E-12;5.02186;37.7692;735.228;356.883;4.89199;552.974;421.048 299.165;2108.09;5.72313E-12;80.1461;148.485;1288.97;1021.06;58.2504;2230.86;2662.07 2 8 2 362282;29397 PCK1_9439;CCL11_33230 757.86 757.86 323.3118477754875 454.9285 454.9285 138.65727582965147 1625.96 1625.96 855.4577838794855 529.244;986.476 356.883;552.974 1021.06;2230.86 8 684352;315852;24832;25671;25682;363131;114494;81639 TWF2_10109;TTK_32727;THY1_33010;SMAD1_32578;PPARD_9536;PIK3R4_9484;CCNA2_8221;ALOX15_8036 341.08571250000074 116.25319999999999 404.07006301453373 217.6650437500007 64.25274999999999 279.79576479941625 830.6470625000009 223.82500000000002 1055.1690083500048 138.399;737.351;5.72311E-12;21.9973;94.1074;955.628;14.384;766.819 90.7363;446.625;5.72311E-12;5.02186;37.7692;735.228;4.89199;421.048 299.165;2108.09;5.72313E-12;80.1461;148.485;1288.97;58.2504;2662.07 0 Exp 2,1(0.1);Exp 4,2(0.2);Exp 5,1(0.1);Hill,1(0.1);Linear,2(0.2);Poly 2,2(0.2);Power,1(0.1) 1.6938270172206051 17.024828910827637 1.5018656253814697 1.9814788103103638 0.1823173288858825 1.6600053310394287 169.27562200654978 679.6055179934513 97.6175617470106 432.6179082529906 351.66297391072976 1627.7563260892712 DOWN 0.2 0.8 0.0 GO:0009408 4 response to heat 54 59 8 8 6 7 5 5 63 54 2425 0.99571 0.019195 0.019195 8.47 81687;291234;25283;245920;686019 mmp9;mki67;gclc;cxcl10;casq1 MMP9_32531;MKI67_9232;GCLC_8699;CXCL10_8408;CASQ1_32992 340.02702 147.66 21.9311 332.2609899374316 274.03412152784523 301.33436485304543 192.256728 96.6023 6.82654 201.8697412751424 154.96374441895875 188.71484585328432 950.7042799999999 397.209 76.1794 962.6805196614774 742.8865220721158 865.7272807177912 1.5 139.68 728.316;21.9311;131.7;670.528;147.66 443.137;6.82654;39.9158;374.802;96.6023 2039.06;76.1794;397.209;1955.3;285.773 0 5 0 5 81687;291234;25283;245920;686019 MMP9_32531;MKI67_9232;GCLC_8699;CXCL10_8408;CASQ1_32992 340.02702 147.66 332.2609899374316 192.256728 96.6023 201.8697412751424 950.7042799999999 397.209 962.6805196614774 728.316;21.9311;131.7;670.528;147.66 443.137;6.82654;39.9158;374.802;96.6023 2039.06;76.1794;397.209;1955.3;285.773 0 Exp 2,1(0.2);Exp 4,1(0.2);Hill,1(0.2);Linear,1(0.2);Poly 2,1(0.2) 2.019457320750633 10.12894880771637 1.8538048267364502 2.327066659927368 0.18328576110616518 1.9746891260147095 48.78742136958357 631.2666186304164 15.310098076126735 369.2033579238733 106.87759962946882 1794.5309603705314 DOWN 0.0 1.0 0.0 GO:0001817 5 regulation of cytokine production 196 207 14 14 8 9 5 5 63 202 2277 0.51951 0.65978 1.0 2.42 688621;24426;24854;24232;29221 tslp;gstp1;clu;c3;arg1 TSLP_32811;GSTP1_8762;CLU_32773;C3_8175;ARG1_33267 458.15461999999997 344.675 14.7631 380.4770900530307 496.15463340448747 358.7766975083007 320.97378399999997 244.2 9.42992 310.64370584474 342.48173320810207 287.82840895372016 998.2701199999999 694.216 25.7196 991.2551496311492 1112.087584403017 1046.0778832334772 344.675;14.7631;935.649;234.759;760.927 244.2;9.42992;808.484;129.148;413.607 560.435;25.7196;1071.05;694.216;2639.93 1 4 1 24426 GSTP1_8762 14.7631 14.7631 9.42992 9.42992 25.7196 25.7196 14.7631 9.42992 25.7196 4 688621;24854;24232;29221 TSLP_32811;CLU_32773;C3_8175;ARG1_33267 569.0024999999999 552.801 333.319773496363 398.85974999999996 328.9035 297.02613461262416 1241.4077499999999 882.633 957.0839294859413 344.675;935.649;234.759;760.927 244.2;808.484;129.148;413.607 560.435;1071.05;694.216;2639.93 0 Exp 2,2(0.4);Exp 4,1(0.2);Poly 2,2(0.4) 1.849700178515285 9.829297661781311 1.513624906539917 3.5281898975372314 0.8758360854949437 1.5548590421676636 124.6517462019649 791.6574937980351 48.682570323895504 593.2649976761045 129.3966721321857 1867.143567867814 DOWN 0.2 0.8 0.0 GO:0010033 4 response to organic substance 795 856 65 63 40 43 31 31 37 825 1654 0.9864 0.02507 0.037591 3.62 116669;684352;360243;25671;89776;25682;288583;25154;362282;24314;81687;291234;24426;25283;24367;25315;312495;24296;245920;84032;24854;113902;114494;29397;686019;24232;25612;29221;81639;24646;170913 vwf;twf2;top2a;smad1;slc22a7;ppard;plod3;pgr;pck1;nqo1;mmp9;mki67;gstp1;gclc;fgg;ephx1;cyp26b1;cyp1a1;cxcl10;col3a1;clu;ces1d;ccna2;ccl11;casq1;c3;asns;arg1;alox15;abcb1b;abcb1a VWF_32396;TWF2_10109;TOP2A_10059;SMAD1_32578;SLC22A7_9847;PPARD_9536;PLOD3_9507;PGR_32824;PCK1_9439;NQO1_33055;MMP9_32531;MKI67_9232;GSTP1_8762;GCLC_8699;FGG_8639;EPHX1_8567;CYP26B1_8418;CYP1A1_8415;CXCL10_8408;COL3A1_8354;CLU_32773;CES1D_32914;CCNA2_8221;CCL11_33230;CASQ1_32992;C3_8175;ASNS_8091;ARG1_33267;ALOX15_8036;ABCB1B_7939;ABCB1A_7938 267.7474129032258 131.7 11.0684 325.3935426318637 223.49836767342288 304.2214713490607 162.2708106451613 39.9158 4.11644 219.62666851687135 130.7906711757059 199.9879513198851 735.8405774193548 285.773 17.0564 854.9242352911117 644.5811361694971 844.7468535868326 19.6764;138.399;86.3883;21.9973;49.1516;94.1074;882.629;283.618;529.244;25.6813;728.316;21.9311;14.7631;131.7;42.4612;39.2381;18.1872;12.8863;670.528;212.603;935.649;11.0684;14.384;986.476;147.66;234.759;191.145;760.927;766.819;20.7941;206.982 4.11644;90.7363;26.6888;5.02186;13.5995;37.7692;625.677;138.711;356.883;7.73944;443.137;6.82654;9.42992;39.9158;20.6424;18.9587;10.0176;9.13136;374.802;119.81;808.484;4.18343;4.89199;552.974;96.6023;129.148;113.564;413.607;421.048;8.25355;118.025 94.078;299.165;262.273;80.1461;161.307;148.485;1106.02;1554.21;1021.06;86.1211;2039.06;76.1794;25.7196;397.209;98.0534;81.6965;36.7271;19.3234;1955.3;1510.69;1071.05;17.0564;58.2504;2230.86;285.773;694.216;510.267;2639.93;2662.07;57.2115;1531.55 7 24 7 362282;24314;24426;25315;312495;24296;29397 PCK1_9439;NQO1_33055;GSTP1_8762;EPHX1_8567;CYP26B1_8418;CYP1A1_8415;CCL11_33230 232.3537142857143 25.6813 382.5855695287588 137.87628857142857 10.0176 223.89305943798138 500.21538571428573 81.6965 845.0115158906168 529.244;25.6813;14.7631;39.2381;18.1872;12.8863;986.476 356.883;7.73944;9.42992;18.9587;10.0176;9.13136;552.974 1021.06;86.1211;25.7196;81.6965;36.7271;19.3234;2230.86 24 116669;684352;360243;25671;89776;25682;288583;25154;81687;291234;25283;24367;245920;84032;24854;113902;114494;686019;24232;25612;29221;81639;24646;170913 VWF_32396;TWF2_10109;TOP2A_10059;SMAD1_32578;SLC22A7_9847;PPARD_9536;PLOD3_9507;PGR_32824;MMP9_32531;MKI67_9232;GCLC_8699;FGG_8639;CXCL10_8408;COL3A1_8354;CLU_32773;CES1D_32914;CCNA2_8221;CASQ1_32992;C3_8175;ASNS_8091;ARG1_33267;ALOX15_8036;ABCB1B_7939;ABCB1A_7938 278.070575 143.02949999999998 315.3239740466072 169.38587958333332 93.66929999999999 222.7229672693699 804.5645916666666 348.187 863.2751158720947 19.6764;138.399;86.3883;21.9973;49.1516;94.1074;882.629;283.618;728.316;21.9311;131.7;42.4612;670.528;212.603;935.649;11.0684;14.384;147.66;234.759;191.145;760.927;766.819;20.7941;206.982 4.11644;90.7363;26.6888;5.02186;13.5995;37.7692;625.677;138.711;443.137;6.82654;39.9158;20.6424;374.802;119.81;808.484;4.18343;4.89199;96.6023;129.148;113.564;413.607;421.048;8.25355;118.025 94.078;299.165;262.273;80.1461;161.307;148.485;1106.02;1554.21;2039.06;76.1794;397.209;98.0534;1955.3;1510.69;1071.05;17.0564;58.2504;285.773;694.216;510.267;2639.93;2662.07;57.2115;1531.55 0 Exp 2,3(0.1);Exp 4,9(0.3);Exp 5,2(0.07);Hill,5(0.17);Linear,2(0.07);Poly 2,9(0.3);Power,1(0.04) 2.0958579156554764 77.36693131923676 1.5021449327468872 15.48720932006836 2.562576825666716 1.8974558115005493 153.20029811938784 382.2945276870637 84.95642694623147 239.58519434409112 434.8846834599945 1036.7964713787155 DOWN 0.22580645161290322 0.7741935483870968 0.0 GO:2001020 6 regulation of response to DNA damage stimulus 41 44 2 2 2 2 2 2 66 42 2437 0.88892 0.32953 0.32953 4.55 316351;24854 npas2;clu NPAS2_9350;CLU_32773 478.3684 478.3684 21.0878 646.6924263301063 410.0356750872601 639.431287696121 409.90725000000003 409.90725000000003 11.3305 563.6726454965906 350.34680633726003 557.3436627275134 557.3062 557.3062 43.5624 726.5434495450907 480.5360204624782 718.3857342294829 21.0878;935.649 11.3305;808.484 43.5624;1071.05 0 2 0 2 316351;24854 NPAS2_9350;CLU_32773 478.3684 478.3684 646.6924263301063 409.90725000000003 409.90725000000003 563.6726454965906 557.3062 557.3062 726.5434495450907 21.0878;935.649 11.3305;808.484 43.5624;1071.05 0 Exp 4,1(0.5);Poly 2,1(0.5) 2.1899570873259107 4.639326453208923 1.5548590421676636 3.0844674110412598 1.0815964501902138 2.3196632266044617 -417.9015759999999 1374.6383759999999 -371.3031799999999 1191.1176799999998 -449.6316479999999 1564.244048 DOWN 0.0 1.0 0.0 GO:0007098 4 centrosome cycle 8 9 2 2 2 1 1 1 67 8 2471 0.9776 0.21646 0.21646 11.11 300795 pclaf NS5ATP9_9367 292.216 292.216 292.216 292.216 147.515 147.515 147.515 147.515 658.494 658.494 658.494 658.494 0.0 292.216 0.0 292.216 292.216 147.515 658.494 0 1 0 1 300795 NS5ATP9_9367 292.216 292.216 147.515 147.515 658.494 658.494 292.216 147.515 658.494 0 Exp 2,1(1) 1.6661498546600342 1.6661498546600342 1.6661498546600342 1.6661498546600342 0.0 1.6661498546600342 292.216 292.216 147.515 147.515 658.494 658.494 DOWN 0.0 1.0 0.0 GO:0019752 6 carboxylic acid metabolic process 287 320 20 20 18 16 16 16 52 304 2175 0.99666 0.0082038 0.013994 5.0 286989;25682;288583;362282;291234;24426;25283;25315;312495;24296;113902;24232;25612;29221;81639;252898 ugt2b7;ppard;plod3;pck1;mki67;gstp1;gclc;ephx1;cyp26b1;cyp1a1;ces1d;c3;asns;arg1;alox15;acox2 UGT2B7_33032;PPARD_9536;PLOD3_9507;PCK1_9439;MKI67_9232;GSTP1_8762;GCLC_8699;EPHX1_8567;CYP26B1_8418;CYP1A1_8415;CES1D_32914;C3_8175;ASNS_8091;ARG1_33267;ALOX15_8036;ACOX2_32902 280.46688750000004 112.90369999999999 11.0684 330.8628589796722 241.92776267235524 307.7202178819776 165.216840625 38.8425 4.18343 208.33340921577704 133.5753109144055 183.78294029123435 739.2983375 272.847 17.0564 957.7402163915668 713.4789814712568 985.8262358797637 15.0 882.629 34.7126;94.1074;882.629;529.244;21.9311;14.7631;131.7;39.2381;18.1872;12.8863;11.0684;234.759;191.145;760.927;766.819;743.353 14.7729;37.7692;625.677;356.883;6.82654;9.42992;39.9158;18.9587;10.0176;9.13136;4.18343;129.148;113.564;413.607;421.048;432.537 105.024;148.485;1106.02;1021.06;76.1794;25.7196;397.209;81.6965;36.7271;19.3234;17.0564;694.216;510.267;2639.93;2662.07;2287.79 6 10 6 286989;362282;24426;25315;312495;24296 UGT2B7_33032;PCK1_9439;GSTP1_8762;EPHX1_8567;CYP26B1_8418;CYP1A1_8415 108.17188333333335 26.4499 206.5679775067899 69.86558 12.39525 140.66172783888132 214.92510000000001 59.2118 396.35712737739937 34.7126;529.244;14.7631;39.2381;18.1872;12.8863 14.7729;356.883;9.42992;18.9587;10.0176;9.13136 105.024;1021.06;25.7196;81.6965;36.7271;19.3234 10 25682;288583;291234;25283;113902;24232;25612;29221;81639;252898 PPARD_9536;PLOD3_9507;MKI67_9232;GCLC_8699;CES1D_32914;C3_8175;ASNS_8091;ARG1_33267;ALOX15_8036;ACOX2_32902 383.84389 212.952 356.48287599565606 222.42759700000002 121.356 227.26187749727364 1053.92228 602.2415 1071.541670476719 94.1074;882.629;21.9311;131.7;11.0684;234.759;191.145;760.927;766.819;743.353 37.7692;625.677;6.82654;39.9158;4.18343;129.148;113.564;413.607;421.048;432.537 148.485;1106.02;76.1794;397.209;17.0564;694.216;510.267;2639.93;2662.07;2287.79 0 Exp 2,3(0.19);Exp 4,6(0.38);Exp 5,2(0.13);Hill,1(0.07);Linear,1(0.07);Poly 2,3(0.19) 2.2549483828210235 47.77493727207184 1.5021449327468872 15.48720932006836 3.5164084872226957 1.863711416721344 118.34408659996063 442.58968840003945 63.133470109269254 267.30021114073077 270.0056314681323 1208.5910435318676 DOWN 0.375 0.625 0.0 GO:0019369 6 arachidonic acid metabolic process 29 34 3 3 3 2 2 2 66 32 2447 0.93957 0.22956 0.22956 5.88 25315;81639 ephx1;alox15 EPHX1_8567;ALOX15_8036 403.02855 403.02855 39.2381 514.4773882518112 438.4319118007662 512.0353376172519 220.00335 220.00335 18.9587 284.320070672552 239.56861478927203 282.97049919505093 1371.88325 1371.88325 81.6965 1824.599599844066 1497.4416540229884 1815.9388409606547 0.5 403.02855 39.2381;766.819 18.9587;421.048 81.6965;2662.07 1 1 1 25315 EPHX1_8567 39.2381 39.2381 18.9587 18.9587 81.6965 81.6965 39.2381 18.9587 81.6965 1 81639 ALOX15_8036 766.819 766.819 421.048 421.048 2662.07 2662.07 766.819 421.048 2662.07 0 Exp 2,1(0.5);Exp 4,1(0.5) 1.7541499128428035 3.5505770444869995 1.5021449327468872 2.0484321117401123 0.38628336874137875 1.7752885222434998 -310.00073199999986 1116.057832 -174.04416399999994 614.0508639999999 -1156.8827799999997 3900.6492799999996 CONFLICT 0.5 0.5 0.0 GO:0044281 3 small molecule metabolic process 449 498 25 25 19 19 17 17 51 481 1998 0.90087 0.15991 0.2767 3.41 286989;25682;288583;362282;291234;24426;25283;25315;64191;312495;24296;113902;24232;25612;29221;81639;252898 ugt2b7;ppard;plod3;pck1;mki67;gstp1;gclc;ephx1;dhcr7;cyp26b1;cyp1a1;ces1d;c3;asns;arg1;alox15;acox2 UGT2B7_33032;PPARD_9536;PLOD3_9507;PCK1_9439;MKI67_9232;GSTP1_8762;GCLC_8699;EPHX1_8567;DHCR7_8466;CYP26B1_8418;CYP1A1_8415;CES1D_32914;C3_8175;ASNS_8091;ARG1_33267;ALOX15_8036;ACOX2_32902 273.48071764705884 131.7 11.0684 321.648960301569 232.30067115167262 289.35334864811546 158.49283235294118 39.9158 4.18343 203.61420061326223 123.65531760467681 174.2804409452041 724.1347294117647 397.209 17.0564 929.4331993947795 685.6435436947061 926.2436455943392 34.7126;94.1074;882.629;529.244;21.9311;14.7631;131.7;39.2381;161.702;18.1872;12.8863;11.0684;234.759;191.145;760.927;766.819;743.353 14.7729;37.7692;625.677;356.883;6.82654;9.42992;39.9158;18.9587;50.9087;10.0176;9.13136;4.18343;129.148;113.564;413.607;421.048;432.537 105.024;148.485;1106.02;1021.06;76.1794;25.7196;397.209;81.6965;481.517;36.7271;19.3234;17.0564;694.216;510.267;2639.93;2662.07;2287.79 6 11 6 286989;362282;24426;25315;312495;24296 UGT2B7_33032;PCK1_9439;GSTP1_8762;EPHX1_8567;CYP26B1_8418;CYP1A1_8415 108.17188333333335 26.4499 206.5679775067899 69.86558 12.39525 140.66172783888132 214.92510000000001 59.2118 396.35712737739937 34.7126;529.244;14.7631;39.2381;18.1872;12.8863 14.7729;356.883;9.42992;18.9587;10.0176;9.13136 105.024;1021.06;25.7196;81.6965;36.7271;19.3234 11 25682;288583;291234;25283;64191;113902;24232;25612;29221;81639;252898 PPARD_9536;PLOD3_9507;MKI67_9232;GCLC_8699;DHCR7_8466;CES1D_32914;C3_8175;ASNS_8091;ARG1_33267;ALOX15_8036;ACOX2_32902 363.64917272727274 191.145 344.75807380437107 206.83497 113.564 221.71512138688163 1001.8854363636364 510.267 1031.1001699462681 94.1074;882.629;21.9311;131.7;161.702;11.0684;234.759;191.145;760.927;766.819;743.353 37.7692;625.677;6.82654;39.9158;50.9087;4.18343;129.148;113.564;413.607;421.048;432.537 148.485;1106.02;76.1794;397.209;481.517;17.0564;694.216;510.267;2639.93;2662.07;2287.79 0 Exp 2,3(0.18);Exp 4,7(0.42);Exp 5,2(0.12);Hill,1(0.06);Linear,1(0.06);Poly 2,3(0.18) 2.2247308054199406 49.56773495674133 1.5021449327468872 15.48720932006836 3.4170232238289557 1.805381178855896 120.57850765416458 426.3829276399531 61.7007854253999 255.28487928048247 282.310232000091 1165.9592268234385 DOWN 0.35294117647058826 0.6470588235294118 0.0 GO:0009615 5 response to virus 66 68 9 9 6 6 4 4 64 64 2415 0.96674 0.10592 0.10592 5.88 304545;24296;245920;24854 oasl;cyp1a1;cxcl10;clu OASL_9389;CYP1A1_8415;CXCL10_8408;CLU_32773 423.91897500000005 373.57030000000003 12.8863 451.75701718632155 458.43811740090223 489.5559120162443 305.216265 201.62485 9.13136 375.22779621119884 361.31705783280546 421.686678057594 826.5156 665.7194999999999 19.3234 876.7382485544778 716.8736961704577 772.7392652946978 2.5 803.0885000000001 76.6126;12.8863;670.528;935.649 28.4477;9.13136;374.802;808.484 260.389;19.3234;1955.3;1071.05 1 3 1 24296 CYP1A1_8415 12.8863 12.8863 9.13136 9.13136 19.3234 19.3234 12.8863 9.13136 19.3234 3 304545;245920;24854 OASL_9389;CXCL10_8408;CLU_32773 560.9298666666667 670.528 439.8803215124011 403.9112333333333 374.802 390.83202009093804 1095.5796666666665 1071.05 847.7217131171841 76.6126;670.528;935.649 28.4477;374.802;808.484 260.389;1955.3;1071.05 0 Exp 2,1(0.25);Exp 4,2(0.5);Poly 2,1(0.25) 3.0318311901735764 20.78861713409424 1.5548590421676636 15.48720932006836 6.8616970824779715 1.8732743859291077 -18.80290184259519 866.6408518425951 -62.50697528697481 672.9395052869748 -32.68788358338827 1685.719083583388 DOWN 0.25 0.75 0.0 GO:0072594 6 establishment of protein localization to organelle 64 68 3 3 3 2 2 2 66 66 2413 0.72797 0.54821 0.70309 2.94 363131;29657 pik3r4;arntl PIK3R4_9484;ARNTL_8086 489.27070000000003 489.27070000000003 22.9134 659.5288185716983 587.9232057692309 644.6034662779 373.31975 373.31975 11.4115 511.81555548471255 449.87726442307695 500.2330025166729 669.5646 669.5646 50.1592 875.9715172871319 800.5926653846154 856.1479961206765 955.628;22.9134 735.228;11.4115 1288.97;50.1592 0 2 0 2 363131;29657 PIK3R4_9484;ARNTL_8086 489.27070000000003 489.27070000000003 659.5288185716983 373.31975 373.31975 511.81555548471255 669.5646 669.5646 875.9715172871319 955.628;22.9134 735.228;11.4115 1288.97;50.1592 0 Exp 4,1(0.5);Poly 2,1(0.5) 2.273959611187957 4.944844961166382 1.5018656253814697 3.442979335784912 1.3725746676804542 2.472422480583191 -424.78960799999993 1403.331008 -336.02041999999983 1082.6599199999998 -544.4699839999997 1883.5991839999997 DOWN 0.0 1.0 0.0 GO:0035962 6 response to interleukin-13 2 2 2 2 2 2 2 2 66 0 2479 1.0 7.0258E-4 7.0258E-4 100.0 29397;81639 ccl11;alox15 CCL11_33230;ALOX15_8036 876.6475 876.6475 766.819 155.3209542350923 874.6960341151386 155.29643391366128 487.011 487.011 421.048 93.28576921481631 485.83894953802417 93.27104230911777 2446.465 2446.465 2230.86 304.911515115452 2450.295934612651 304.863379122499 0.0 766.819 0.0 766.819 986.476;766.819 552.974;421.048 2230.86;2662.07 1 1 1 29397 CCL11_33230 986.476 986.476 552.974 552.974 2230.86 2230.86 986.476 552.974 2230.86 1 81639 ALOX15_8036 766.819 766.819 421.048 421.048 2662.07 2662.07 766.819 421.048 2662.07 0 Exp 2,1(0.5);Power,1(0.5) 1.725244433189988 3.483623743057251 1.5021449327468872 1.9814788103103638 0.3389402352775766 1.7418118715286255 661.38364 1091.91136 357.72352 616.29848 2023.8792000000003 2869.0508 CONFLICT 0.5 0.5 0.0 GO:0045787 6 positive regulation of cell cycle 111 119 4 4 3 3 3 3 65 116 2363 0.60632 0.62452 1.0 2.52 361921;24296;25612 ect2;cyp1a1;asns ECT2_8523;CYP1A1_8415;ASNS_8091 71.34916666666668 12.8863 10.0162 103.75615948715206 84.52699718394972 108.44439533591333 41.996469999999995 9.13136 3.29405 62.047981915084875 49.487646069615664 65.22175680051508 189.10696666666664 37.7305 19.3234 278.2849808929748 226.85022579163643 288.3692221795684 10.0162;12.8863;191.145 3.29405;9.13136;113.564 37.7305;19.3234;510.267 1 2 1 24296 CYP1A1_8415 12.8863 12.8863 9.13136 9.13136 19.3234 19.3234 12.8863 9.13136 19.3234 2 361921;25612 ECT2_8523;ASNS_8091 100.5806 100.5806 128.07740274818192 58.429024999999996 58.429024999999996 77.97262940610153 273.99875 273.99875 334.133763508157 10.0162;191.145 3.29405;113.564 37.7305;510.267 0 Exp 4,2(0.67);Poly 2,1(0.34) 3.5762447051726536 18.928425908088684 1.6358354091644287 15.48720932006836 7.948602878004868 1.805381178855896 -46.061980688911746 188.7603140222451 -28.217431360240674 112.21037136024066 -125.80213424811149 504.0160675814448 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0043603 5 cellular amide metabolic process 114 134 8 8 6 5 5 5 63 129 2350 0.85527 0.28574 0.40343 3.73 24426;156275;25283;25612;29221 gstp1;ggt7;gclc;asns;arg1 GSTP1_8762;GGT7_33026;GCLC_8699;ASNS_8091;ARG1_33267 241.62882 131.7 14.7631 297.1535163361053 250.667945335848 283.7324217691289 121.170064 39.9158 9.42992 168.15117087459274 124.7950810953141 162.28551793930453 783.8397199999999 397.209 25.7196 1053.0648474541783 805.9744357609168 1011.4463316255683 14.7631;109.609;131.7;191.145;760.927 9.42992;29.3336;39.9158;113.564;413.607 25.7196;346.073;397.209;510.267;2639.93 1 4 1 24426 GSTP1_8762 14.7631 14.7631 9.42992 9.42992 25.7196 25.7196 14.7631 9.42992 25.7196 4 156275;25283;25612;29221 GGT7_33026;GCLC_8699;ASNS_8091;ARG1_33267 298.34524999999996 161.4225 310.304033943459 149.1051 76.73989999999999 180.27011246049636 973.36975 453.738 1113.1561205776945 109.609;131.7;191.145;760.927 29.3336;39.9158;113.564;413.607 346.073;397.209;510.267;2639.93 0 Exp 2,1(0.2);Exp 4,2(0.4);Hill,1(0.2);Poly 2,1(0.2) 2.0562428067336413 10.752671003341675 1.513624906539917 3.5281898975372314 0.7908745293849011 1.930785894393921 -18.837721214005228 502.09536121400527 -26.220935840134672 268.5610638401347 -139.21231678021184 1706.8917567802118 DOWN 0.2 0.8 0.0 GO:0048511 2 rhythmic process 111 122 13 13 10 9 7 7 61 115 2364 0.9855 0.041652 0.041652 5.74 360243;25154;259241;316351;24854;29657;170913 top2a;pgr;nr1d2;npas2;clu;arntl;abcb1a TOP2A_10059;PGR_32824;NR1D2_9358;NPAS2_9350;CLU_32773;ARNTL_8086;ABCB1A_7938 226.5444714285714 86.3883 21.0878 328.8228237592839 211.58104862482713 309.5601233390877 159.71505285714287 26.6888 3.35457 291.32939014847824 145.87099345063857 275.96866251736486 660.9775142857143 262.273 43.5624 699.5628073270891 660.8915029562197 682.6004247234619 5.5 609.6335 86.3883;283.618;29.1728;21.0878;935.649;22.9134;206.982 26.6888;138.711;3.35457;11.3305;808.484;11.4115;118.025 262.273;1554.21;114.038;43.5624;1071.05;50.1592;1531.55 1 6 1 259241 NR1D2_9358 29.1728 29.1728 3.35457 3.35457 114.038 114.038 29.1728 3.35457 114.038 6 360243;25154;316351;24854;29657;170913 TOP2A_10059;PGR_32824;NPAS2_9350;CLU_32773;ARNTL_8086;ABCB1A_7938 259.43975 146.68515 347.361058195623 185.77513333333334 72.3569 310.06886784062453 752.1340999999999 666.6614999999999 719.3509237320184 86.3883;283.618;21.0878;935.649;22.9134;206.982 26.6888;138.711;11.3305;808.484;11.4115;118.025 262.273;1554.21;43.5624;1071.05;50.1592;1531.55 0 Exp 4,4(0.58);Poly 2,3(0.43) 2.139814642744846 15.653079748153687 1.5405861139297485 3.442979335784912 0.7443772488337517 1.9603345394134521 -17.05088535077263 470.13982820791546 -56.10477960521257 375.5348853194983 142.73413418156622 1179.2208943898622 DOWN 0.14285714285714285 0.8571428571428571 0.0 GO:0042276 9 error-prone translesion synthesis 1 1 1 1 1 1 1 1 67 0 2479 1.0 0.026698 0.026698 100.0 299112 pole2 POLE2_9520 2.71598E-7 2.71598E-7 2.71598E-7 2.71598E-7 2.71598E-7 2.71598E-7 2.71598E-7 2.71598E-7 2.71599E-7 2.71599E-7 2.71599E-7 2.71599E-7 0.0 2.71598E-7 0.0 2.71598E-7 2.71598E-7 2.71598E-7 2.71599E-7 0 1 0 1 299112 POLE2_9520 2.71598E-7 2.71598E-7 2.71598E-7 2.71598E-7 2.71599E-7 2.71599E-7 2.71598E-7 2.71598E-7 2.71599E-7 0 Hill,1(1) 1.6493386030197144 1.6493386030197144 1.6493386030197144 1.6493386030197144 0.0 1.6493386030197144 2.71598E-7 2.71598E-7 2.71598E-7 2.71598E-7 2.71599E-7 2.71599E-7 DOWN 0.0 1.0 0.0 GO:0019222 4 regulation of metabolic process 1092 1179 65 62 43 37 29 29 39 1150 1329 0.31394 0.76796 0.62232 2.46 688621;360243;24832;25671;295703;25682;363131;25154;362282;304545;259241;316351;81687;24426;25283;24367;361921;64191;312495;24854;306575;113902;114494;29397;24232;246142;29657;29221;81639 tslp;top2a;thy1;smad1;serping1;ppard;pik3r4;pgr;pck1;oasl;nr1d2;npas2;mmp9;gstp1;gclc;fgg;ect2;dhcr7;cyp26b1;clu;ckap2;ces1d;ccna2;ccl11;c3;bmf;arntl;arg1;alox15 TSLP_32811;TOP2A_10059;THY1_33010;SMAD1_32578;SERPING1_32597;PPARD_9536;PIK3R4_9484;PGR_32824;PCK1_9439;OASL_9389;NR1D2_9358;NPAS2_9350;MMP9_32531;GSTP1_8762;GCLC_8699;FGG_8639;ECT2_8523;DHCR7_8466;CYP26B1_8418;CLU_32773;CKAP2_8324;CES1D_32914;CCNA2_8221;CCL11_33230;C3_8175;BMF_8152;ARNTL_8086;ARG1_33267;ALOX15_8036 257.4728275862071 86.3883 5.72311E-12 335.85459543475565 243.7380140591904 320.51695586171775 159.36399034482778 28.4477 5.72311E-12 235.00245193212677 143.82569742671575 215.5872010964766 629.9812344827589 220.085 5.72313E-12 832.3106011208281 625.0332777317769 850.2283047811517 344.675;86.3883;5.72311E-12;21.9973;32.3997;94.1074;955.628;283.618;529.244;76.6126;29.1728;21.0878;728.316;14.7631;131.7;42.4612;10.0162;161.702;18.1872;935.649;32.2386;11.0684;14.384;986.476;234.759;119.401;22.9134;760.927;766.819 244.2;26.6888;5.72311E-12;5.02186;13.7308;37.7692;735.228;138.711;356.883;28.4477;3.35457;11.3305;443.137;9.42992;39.9158;20.6424;3.29405;50.9087;10.0176;808.484;15.2683;4.18343;4.89199;552.974;129.148;81.8286;11.4115;413.607;421.048 560.435;262.273;5.72313E-12;80.1461;99.4885;148.485;1288.97;1554.21;1021.06;260.389;114.038;43.5624;2039.06;25.7196;397.209;98.0534;37.7305;481.517;36.7271;1071.05;76.7052;17.0564;58.2504;2230.86;694.216;220.085;50.1592;2639.93;2662.07 5 24 5 362282;259241;24426;312495;29397 PCK1_9439;NR1D2_9358;GSTP1_8762;CYP26B1_8418;CCL11_33230 315.56862 29.1728 434.9471565873744 186.53181800000002 10.0176 254.64468066991193 685.68094 114.038 959.6253369083885 529.244;29.1728;14.7631;18.1872;986.476 356.883;3.35457;9.42992;10.0176;552.974 1021.06;114.038;25.7196;36.7271;2230.86 24 688621;360243;24832;25671;295703;25682;363131;25154;304545;316351;81687;25283;24367;361921;64191;24854;306575;113902;114494;24232;246142;29657;29221;81639 TSLP_32811;TOP2A_10059;THY1_33010;SMAD1_32578;SERPING1_32597;PPARD_9536;PIK3R4_9484;PGR_32824;OASL_9389;NPAS2_9350;MMP9_32531;GCLC_8699;FGG_8639;ECT2_8523;DHCR7_8466;CLU_32773;CKAP2_8324;CES1D_32914;CCNA2_8221;C3_8175;BMF_8152;ARNTL_8086;ARG1_33267;ALOX15_8036 245.36953750000023 90.24785 321.7645092822209 153.70402625000023 33.10845 236.1371483470882 618.3771291666669 240.23700000000002 826.0560847235658 344.675;86.3883;5.72311E-12;21.9973;32.3997;94.1074;955.628;283.618;76.6126;21.0878;728.316;131.7;42.4612;10.0162;161.702;935.649;32.2386;11.0684;14.384;234.759;119.401;22.9134;760.927;766.819 244.2;26.6888;5.72311E-12;5.02186;13.7308;37.7692;735.228;138.711;28.4477;11.3305;443.137;39.9158;20.6424;3.29405;50.9087;808.484;15.2683;4.18343;4.89199;129.148;81.8286;11.4115;413.607;421.048 560.435;262.273;5.72313E-12;80.1461;99.4885;148.485;1288.97;1554.21;260.389;43.5624;2039.06;397.209;98.0534;37.7305;481.517;1071.05;76.7052;17.0564;58.2504;694.216;220.085;50.1592;2639.93;2662.07 0 Exp 2,3(0.11);Exp 4,14(0.49);Exp 5,2(0.07);Hill,2(0.07);Linear,2(0.07);Poly 2,5(0.18);Power,1(0.04) 1.9059116739326984 57.021331906318665 1.5018656253814697 3.5281898975372314 0.5572479647001941 1.7927976846694946 135.23422753816226 379.7114276342519 73.83182516824134 244.8961555214142 327.05108533754304 932.9113836279748 DOWN 0.1724137931034483 0.8275862068965517 0.0 GO:0070527 6 platelet aggregation 12 12 2 2 2 2 2 2 66 10 2469 0.99663 0.039009 0.039009 16.67 24367;309186 fgg;fermt3 FGG_8639;FERMT3_32542 290.7871 290.7871 42.4612 351.185855668505 202.22915980605583 328.09524178023617 177.4452 177.4452 20.6424 221.75264637807592 121.5262121511973 207.17231902841394 642.9567 642.9567 98.0534 770.6096370418553 448.6333778943202 719.9417376936863 0.0 42.4612 0.5 290.7871 42.4612;539.113 20.6424;334.248 98.0534;1187.86 0 2 0 2 24367;309186 FGG_8639;FERMT3_32542 290.7871 290.7871 351.185855668505 177.4452 177.4452 221.75264637807592 642.9567 642.9567 770.6096370418553 42.4612;539.113 20.6424;334.248 98.0534;1187.86 0 Exp 2,1(0.5);Exp 4,1(0.5) 2.1694491519358614 4.488012194633484 1.6703740358352661 2.8176381587982178 0.8112382411591402 2.244006097316742 -195.931664 777.505864 -129.88828799999993 484.77868799999993 -425.053768 1710.967168 DOWN 0.0 1.0 0.0 GO:0046777 8 protein autophosphorylation 52 55 3 3 3 2 2 2 66 53 2426 0.8201 0.43534 0.65745 3.64 315852;24832 ttk;thy1 TTK_32727;THY1_33010 368.67550000000284 368.67550000000284 5.72311E-12 521.3858922146779 396.86447613185874 519.8596078267392 223.31250000000287 223.31250000000287 5.72311E-12 315.81156614743776 240.38700246204613 314.88707189061415 1054.045000000003 1054.045000000003 5.72313E-12 1490.644734351545 1134.6374162221337 1486.2810800602106 737.351;5.72311E-12 446.625;5.72311E-12 2108.09;5.72313E-12 0 2 0 2 315852;24832 TTK_32727;THY1_33010 368.67550000000284 368.67550000000284 521.3858922146779 223.31250000000287 223.31250000000287 315.81156614743776 1054.045000000003 1054.045000000003 1490.644734351545 737.351;5.72311E-12 446.625;5.72311E-12 2108.09;5.72313E-12 0 Hill,1(0.5);Linear,1(0.5) 1.6779717438156034 3.3743585348129272 1.5111545324325562 1.863204002380371 0.24893656751322962 1.6871792674064636 -353.92847999999145 1091.2794799999972 -214.37999999999155 661.0049999999973 -1011.8831999999913 3119.9731999999976 DOWN 0.0 1.0 0.0 GO:1902903 6 regulation of supramolecular fiber organization 89 94 7 7 5 7 5 5 63 89 2390 0.96266 0.10354 0.10354 5.32 684352;24854;306575;29397;81639 twf2;clu;ckap2;ccl11;alox15 TWF2_10109;CLU_32773;CKAP2_8324;CCL11_33230;ALOX15_8036 571.91632 766.819 32.2386 453.1383766735191 520.375553641586 469.77330064537324 377.70212000000004 421.048 15.2683 328.58780451201625 335.1578045836179 328.38361866342996 1267.9700400000002 1071.05 76.7052 1147.5130064888187 1199.469230691359 1197.8848551514982 3.5 961.0625 138.399;935.649;32.2386;986.476;766.819 90.7363;808.484;15.2683;552.974;421.048 299.165;1071.05;76.7052;2230.86;2662.07 1 4 1 29397 CCL11_33230 986.476 986.476 552.974 552.974 2230.86 2230.86 986.476 552.974 2230.86 4 684352;24854;306575;81639 TWF2_10109;CLU_32773;CKAP2_8324;ALOX15_8036 468.27639999999997 452.609 449.6342562962035 333.88415 255.89215000000002 362.1599514016287 1027.24755 685.1075 1170.2133788912217 138.399;935.649;32.2386;766.819 90.7363;808.484;15.2683;421.048 299.165;1071.05;76.7052;2662.07 0 Exp 2,1(0.2);Exp 4,1(0.2);Poly 2,2(0.4);Power,1(0.2) 1.764302520815488 8.891358256340027 1.5021449327468872 2.0582168102264404 0.24803736320406478 1.7946586608886719 174.72302032528978 969.1096196747103 89.68221035321807 665.722029646782 262.1305416709308 2273.8095383290693 DOWN 0.2 0.8 0.0 GO:0051336 5 regulation of hydrolase activity 294 317 21 19 11 11 7 7 61 310 2169 0.37505 0.76104 0.71109 2.21 24832;295703;304545;81687;361921;29397;24232 thy1;serping1;oasl;mmp9;ect2;ccl11;c3 THY1_33010;SERPING1_32597;OASL_9389;MMP9_32531;ECT2_8523;CCL11_33230;C3_8175 295.51135714285795 76.6126 5.72311E-12 398.83616151902817 367.06879384358314 430.1176307776789 167.24736428571512 28.4477 5.72311E-12 232.39217664496283 211.83806102792744 251.24966205682077 765.9634285714294 260.389 5.72313E-12 965.1132959465782 947.2873600529293 1058.8897027838239 5.72311E-12;32.3997;76.6126;728.316;10.0162;986.476;234.759 5.72311E-12;13.7308;28.4477;443.137;3.29405;552.974;129.148 5.72313E-12;99.4885;260.389;2039.06;37.7305;2230.86;694.216 1 6 1 29397 CCL11_33230 986.476 986.476 552.974 552.974 2230.86 2230.86 986.476 552.974 2230.86 6 24832;295703;304545;81687;361921;24232 THY1_33010;SERPING1_32597;OASL_9389;MMP9_32531;ECT2_8523;C3_8175 180.35058333333427 54.506150000000005 281.92819716596154 102.95959166666762 21.08925 173.46711437349208 521.8140000000009 179.93875 785.5044771690985 5.72311E-12;32.3997;76.6126;728.316;10.0162;234.759 5.72311E-12;13.7308;28.4477;443.137;3.29405;129.148 5.72313E-12;99.4885;260.389;2039.06;37.7305;694.216 0 Exp 4,3(0.43);Hill,1(0.15);Linear,1(0.15);Poly 2,1(0.15);Power,1(0.15) 1.8045882990849322 12.689687132835388 1.5467612743377686 2.05134654045105 0.18498138124572985 1.863204002380371 0.0493939159554202 590.9733203697605 -4.911169405362898 339.40589797679314 50.99749351000162 1480.929363632857 DOWN 0.14285714285714285 0.8571428571428571 0.0 GO:0071704 3 organic substance metabolic process 1263 1393 79 79 55 54 42 42 26 1351 1128 0.90573 0.14348 0.26703 3.02 286989;315852;360243;24832;25671;291463;25682;299112;288583;363131;25154;362282;300795;313108;81687;291234;316273;293502;362376;24426;156275;25283;81919;24367;29243;25315;64191;312495;24296;84032;113902;297594;114494;29397;24232;116599;25612;29657;29221;81639;26760;252898 ugt2b7;ttk;top2a;thy1;smad1;ppic;ppard;pole2;plod3;pik3r4;pgr;pck1;pclaf;mms22l;mmp9;mki67;mcm3;kif22;herc6;gstp1;ggt7;gclc;fut1;fgg;f10;ephx1;dhcr7;cyp26b1;cyp1a1;col3a1;ces1d;cdca3;ccna2;ccl11;c3;blvra;asns;arntl;arg1;alox15;akr7a3;acox2 UGT2B7_33032;TTK_32727;TOP2A_10059;THY1_33010;SMAD1_32578;PPIC_9541;PPARD_9536;POLE2_9520;PLOD3_9507;PIK3R4_9484;PGR_32824;PCK1_9439;NS5ATP9_9367;MMS22L_33129;MMP9_32531;MKI67_9232;MCM3_9207;KIF22_8963;HERC6_8794;GSTP1_8762;GGT7_33026;GCLC_8699;FUT1_8668;FGG_8639;F10_8585;EPHX1_8567;DHCR7_8466;CYP26B1_8418;CYP1A1_8415;COL3A1_8354;CES1D_32914;CDCA3_8260;CCNA2_8221;CCL11_33230;C3_8175;BLVRA_8151;ASNS_8091;ARNTL_8086;ARG1_33267;ALOX15_8036;AKR7A3_8015;ACOX2_32902 262.45688333980013 118.131 5.72311E-12 309.510679194842 222.9705590417261 286.2005417498571 153.01617714932388 39.169349999999994 5.72311E-12 201.86279723676932 122.09405091482625 177.43828380832474 695.0054190540859 304.173 5.72313E-12 811.2426042373058 625.6333306496966 805.4726527798861 34.7126;737.351;86.3883;5.72311E-12;21.9973;628.678;94.1074;2.71598E-7;882.629;955.628;283.618;529.244;292.216;126.653;728.316;21.9311;197.273;17.3097;39.6865;14.7631;109.609;131.7;240.861;42.4612;104.19;39.2381;161.702;18.1872;12.8863;212.603;11.0684;56.6562;14.384;986.476;234.759;415.991;191.145;22.9134;760.927;766.819;52.7573;743.353 14.7729;446.625;26.6888;5.72311E-12;5.02186;389.239;37.7692;2.71598E-7;625.677;735.228;138.711;356.883;147.515;85.587;443.137;6.82654;116.413;3.12114;15.7729;9.42992;29.3336;39.9158;78.9726;20.6424;38.4229;18.9587;50.9087;10.0176;9.13136;119.81;4.18343;22.3266;4.89199;552.974;129.148;288.048;113.564;11.4115;413.607;421.048;12.408;432.537 105.024;2108.09;262.273;5.72313E-12;80.1461;1509.86;148.485;2.71599E-7;1106.02;1288.97;1554.21;1021.06;658.494;240.486;2039.06;76.1794;496.915;90.6321;157.407;25.7196;346.073;397.209;847.87;98.0534;163.044;81.6965;481.517;36.7271;19.3234;1510.69;17.0564;150.565;58.2504;2230.86;694.216;720.942;510.267;50.1592;2639.93;2662.07;216.887;2287.79 8 34 8 286989;362282;24426;25315;312495;24296;29397;26760 UGT2B7_33032;PCK1_9439;GSTP1_8762;EPHX1_8567;CYP26B1_8418;CYP1A1_8415;CCL11_33230;AKR7A3_8015 211.033075 36.975350000000006 359.2049049233907 123.071935 13.59045 211.44955415565002 467.1622 93.36025000000001 787.4464875489872 34.7126;529.244;14.7631;39.2381;18.1872;12.8863;986.476;52.7573 14.7729;356.883;9.42992;18.9587;10.0176;9.13136;552.974;12.408 105.024;1021.06;25.7196;81.6965;36.7271;19.3234;2230.86;216.887 34 315852;360243;24832;25671;291463;25682;299112;288583;363131;25154;300795;313108;81687;291234;316273;293502;362376;156275;25283;81919;24367;29243;64191;84032;113902;297594;114494;24232;116599;25612;29657;29221;81639;252898 TTK_32727;TOP2A_10059;THY1_33010;SMAD1_32578;PPIC_9541;PPARD_9536;POLE2_9520;PLOD3_9507;PIK3R4_9484;PGR_32824;NS5ATP9_9367;MMS22L_33129;MMP9_32531;MKI67_9232;MCM3_9207;KIF22_8963;HERC6_8794;GGT7_33026;GCLC_8699;FUT1_8668;FGG_8639;F10_8585;DHCR7_8466;COL3A1_8354;CES1D_32914;CDCA3_8260;CCNA2_8221;C3_8175;BLVRA_8151;ASNS_8091;ARNTL_8086;ARG1_33267;ALOX15_8036;ACOX2_32902 274.5566029491648 146.701 301.4279733104747 160.06188118445894 64.94065 202.17414188320265 748.6155882432824 439.363 818.8901453855901 737.351;86.3883;5.72311E-12;21.9973;628.678;94.1074;2.71598E-7;882.629;955.628;283.618;292.216;126.653;728.316;21.9311;197.273;17.3097;39.6865;109.609;131.7;240.861;42.4612;104.19;161.702;212.603;11.0684;56.6562;14.384;234.759;415.991;191.145;22.9134;760.927;766.819;743.353 446.625;26.6888;5.72311E-12;5.02186;389.239;37.7692;2.71598E-7;625.677;735.228;138.711;147.515;85.587;443.137;6.82654;116.413;3.12114;15.7729;29.3336;39.9158;78.9726;20.6424;38.4229;50.9087;119.81;4.18343;22.3266;4.89199;129.148;288.048;113.564;11.4115;413.607;421.048;432.537 2108.09;262.273;5.72313E-12;80.1461;1509.86;148.485;2.71599E-7;1106.02;1288.97;1554.21;658.494;240.486;2039.06;76.1794;496.915;90.6321;157.407;346.073;397.209;847.87;98.0534;163.044;481.517;1510.69;17.0564;150.565;58.2504;694.216;720.942;510.267;50.1592;2639.93;2662.07;2287.79 0 Exp 2,7(0.17);Exp 4,15(0.36);Exp 5,3(0.08);Hill,5(0.12);Linear,3(0.08);Poly 2,8(0.2);Power,1(0.03) 1.985405071938398 96.64181089401245 1.5018656253814697 15.48720932006836 2.225130390497952 1.7850995659828186 168.85015542813943 356.0636112514608 91.96588969047392 214.0664646081738 449.65761418114164 940.35322392703 DOWN 0.19047619047619047 0.8095238095238095 0.0 GO:0008654 5 phospholipid biosynthetic process 31 34 3 3 3 2 2 2 66 32 2447 0.93957 0.22956 0.22956 5.88 25682;81639 ppard;alox15 PPARD_9536;ALOX15_8036 430.4632 430.4632 94.1074 475.6789341428522 470.40545125 472.31311808740156 229.4086 229.4086 37.7692 271.0190385650425 252.16577875000002 269.10135803336465 1405.2775000000001 1405.2775000000001 148.485 1777.372998588788 1554.521609375 1764.7966363709522 0.5 430.4632 94.1074;766.819 37.7692;421.048 148.485;2662.07 0 2 0 2 25682;81639 PPARD_9536;ALOX15_8036 430.4632 430.4632 475.6789341428522 229.4086 229.4086 271.0190385650425 1405.2775000000001 1405.2775000000001 1777.372998588788 94.1074;766.819 37.7692;421.048 148.485;2662.07 0 Exp 2,1(0.5);Exp 5,1(0.5) 1.7066070278324659 3.4410440921783447 1.5021449327468872 1.9388991594314575 0.30883187540054624 1.7205220460891724 -228.79416799999996 1089.720568 -146.2046239999999 605.0218239999999 -1058.0357999999997 3868.5908 DOWN 0.0 1.0 0.0 GO:0098754 2 detoxification 44 58 7 7 5 3 3 3 65 55 2424 0.93293 0.2004 0.2004 5.17 24314;24426;26760 nqo1;gstp1;akr7a3 NQO1_33055;GSTP1_8762;AKR7A3_8015 31.067233333333334 25.6813 14.7631 19.561339852201666 28.592475603053433 16.014844050385367 9.859119999999999 9.42992 7.73944 2.3636883462927196 9.108201209160304 2.2232806564419816 109.5759 86.1211 25.7196 97.71816329613445 98.31990183206106 79.82083161339864 1.5 39.219300000000004 25.6813;14.7631;52.7573 7.73944;9.42992;12.408 86.1211;25.7196;216.887 3 0 3 24314;24426;26760 NQO1_33055;GSTP1_8762;AKR7A3_8015 31.067233333333334 25.6813 19.561339852201666 9.859119999999999 9.42992 2.3636883462927196 109.5759 86.1211 97.71816329613445 25.6813;14.7631;52.7573 7.73944;9.42992;12.408 86.1211;25.7196;216.887 0 0 Exp 4,1(0.34);Hill,2(0.67) 2.284840124352122 7.256933808326721 1.5559667348861694 3.5281898975372314 1.008898984818944 2.1727771759033203 8.93149346775169 53.202973198914975 7.184354838095535 12.533885161904463 -1.0026114521285194 220.15441145212853 UP 1.0 0.0 0.0 GO:0030336 7 negative regulation of cell migration 73 78 6 6 4 6 4 4 64 74 2405 0.94502 0.1529 0.1529 5.13 24832;25682;24426;84032 thy1;ppard;gstp1;col3a1 THY1_33010;PPARD_9536;GSTP1_8762;COL3A1_8354 80.36837500000144 54.435249999999996 5.72311E-12 97.36167052936624 73.71426395162055 90.60745364801629 41.752280000001434 23.599559999999997 5.72311E-12 54.45750765215121 37.19777213197729 50.110234824789565 421.22365000000144 87.10230000000001 5.72313E-12 729.1950164100742 347.3040464518119 666.9595792903609 2.5 153.3552 5.72311E-12;94.1074;14.7631;212.603 5.72311E-12;37.7692;9.42992;119.81 5.72313E-12;148.485;25.7196;1510.69 1 3 1 24426 GSTP1_8762 14.7631 14.7631 9.42992 9.42992 25.7196 25.7196 14.7631 9.42992 25.7196 3 24832;25682;84032 THY1_33010;PPARD_9536;COL3A1_8354 102.2368000000019 94.1074 106.53438065018925 52.52640000000191 37.7692 61.25308350507507 553.0583333333353 148.485 832.6498397035397 5.72311E-12;94.1074;212.603 5.72311E-12;37.7692;119.81 5.72313E-12;148.485;1510.69 0 Exp 4,1(0.25);Exp 5,1(0.25);Hill,1(0.25);Poly 2,1(0.25) 2.1293620563452116 8.943278551101685 1.6129854917526245 3.5281898975372314 0.8727633210994491 1.9010515809059143 -15.046062118777456 175.78281211878033 -11.616077499106751 95.12063749910962 -293.3874660818713 1135.8347660818742 DOWN 0.25 0.75 0.0 GO:0048589 3 developmental growth 91 95 2 2 2 2 2 2 66 93 2386 0.53019 0.73004 1.0 2.11 64191;29397 dhcr7;ccl11 DHCR7_8466;CCL11_33230 574.0889999999999 574.0889999999999 161.702 583.2032883463537 445.16312249538163 553.9695946144772 301.94135 301.94135 50.9087 355.0137782284584 223.46020320449057 337.2183297618449 1356.1885 1356.1885 481.517 1236.9722979212188 1082.7371286769933 1174.9677275855854 161.702;986.476 50.9087;552.974 481.517;2230.86 1 1 1 29397 CCL11_33230 986.476 986.476 552.974 552.974 2230.86 2230.86 986.476 552.974 2230.86 1 64191 DHCR7_8466 161.702 161.702 50.9087 50.9087 481.517 481.517 161.702 50.9087 481.517 0 Exp 4,1(0.5);Power,1(0.5) 1.8847786669383981 3.7742764949798584 1.7927976846694946 1.9814788103103638 0.13341770342256953 1.8871382474899292 -234.18952000000002 1382.3675199999998 -190.08264399999996 793.965344 -358.16764000000035 3070.54464 CONFLICT 0.5 0.5 0.0 GO:2001243 8 negative regulation of intrinsic apoptotic signaling pathway 39 41 3 3 3 2 2 2 66 39 2440 0.9055 0.29965 0.29965 4.88 81687;24854 mmp9;clu MMP9_32531;CLU_32773 831.9825000000001 831.9825000000001 728.316 146.6065702637506 804.3927332015811 141.31912814802288 625.8105 625.8105 443.137 258.3393411861614 577.1938372859025 249.0221986441922 1555.0549999999998 1555.0549999999998 1071.05 684.4864352563902 1683.8679249011857 659.8000763919339 728.316;935.649 443.137;808.484 2039.06;1071.05 0 2 0 2 81687;24854 MMP9_32531;CLU_32773 831.9825000000001 831.9825000000001 146.6065702637506 625.8105 625.8105 258.3393411861614 1555.0549999999998 1555.0549999999998 684.4864352563902 728.316;935.649 443.137;808.484 2039.06;1071.05 0 Linear,1(0.5);Poly 2,1(0.5) 1.78593245030143 3.6062055826187134 1.5548590421676636 2.05134654045105 0.35106967681052675 1.8031027913093567 628.7961600000001 1035.16884 267.77044 983.8505600000001 606.4051999999998 2503.7048 DOWN 0.0 1.0 0.0 GO:0001932 8 regulation of protein phosphorylation 371 395 29 27 16 14 11 11 57 384 2095 0.6394 0.49125 0.86517 2.78 688621;24832;81687;24426;24367;361921;24854;114494;29397;24232;81639 tslp;thy1;mmp9;gstp1;fgg;ect2;clu;ccna2;ccl11;c3;alox15 TSLP_32811;THY1_33010;MMP9_32531;GSTP1_8762;FGG_8639;ECT2_8523;CLU_32773;CCNA2_8221;CCL11_33230;C3_8175;ALOX15_8036 370.7562272727278 234.759 5.72311E-12 403.88219987626553 372.43208380813195 399.494463153802 239.74994181818235 129.148 5.72311E-12 278.8656884038424 237.29541831174092 268.0296353983108 861.5859000000005 560.435 5.72313E-12 1000.687255211148 887.3380833220655 1024.1602230468204 344.675;5.72311E-12;728.316;14.7631;42.4612;10.0162;935.649;14.384;986.476;234.759;766.819 244.2;5.72311E-12;443.137;9.42992;20.6424;3.29405;808.484;4.89199;552.974;129.148;421.048 560.435;5.72313E-12;2039.06;25.7196;98.0534;37.7305;1071.05;58.2504;2230.86;694.216;2662.07 2 9 2 24426;29397 GSTP1_8762;CCL11_33230 500.61955 500.61955 687.1047809564456 281.20196000000004 281.20196000000004 384.3437048418033 1128.2898 1128.2898 1559.2697303084162 14.7631;986.476 9.42992;552.974 25.7196;2230.86 9 688621;24832;81687;24367;361921;24854;114494;24232;81639 TSLP_32811;THY1_33010;MMP9_32531;FGG_8639;ECT2_8523;CLU_32773;CCNA2_8221;C3_8175;ALOX15_8036 341.89771111111173 234.759 373.80995221180325 230.53838222222282 129.148 279.6740118297473 802.3183666666672 560.435 962.3247912248073 344.675;5.72311E-12;728.316;42.4612;10.0162;935.649;14.384;234.759;766.819 244.2;5.72311E-12;443.137;20.6424;3.29405;808.484;4.89199;129.148;421.048 560.435;5.72313E-12;2039.06;98.0534;37.7305;1071.05;58.2504;694.216;2662.07 0 Exp 2,2(0.19);Exp 4,4(0.37);Hill,1(0.1);Linear,1(0.1);Poly 2,2(0.19);Power,1(0.1) 1.908033854562906 21.794115781784058 1.5021449327468872 3.5281898975372314 0.6359049617353534 1.6858625411987305 132.0770996067207 609.4353549387349 74.95085123037984 404.5490324059848 270.21752275173264 1452.9542772482687 DOWN 0.18181818181818182 0.8181818181818182 0.0 GO:0046486 5 glycerolipid metabolic process 62 68 3 3 3 2 2 2 66 66 2413 0.72797 0.54821 0.70309 2.94 113902;81639 ces1d;alox15 CES1D_32914;ALOX15_8036 388.9437 388.9437 11.0684 534.3963741458019 577.598763027221 463.0313370481208 212.615715 212.615715 4.18343 294.76776428341424 316.6759853155848 255.40351435392836 1339.5632 1339.5632 17.0564 1870.3070528906424 1999.8275880346994 1620.54014077986 11.0684;766.819 4.18343;421.048 17.0564;2662.07 0 2 0 2 113902;81639 CES1D_32914;ALOX15_8036 388.9437 388.9437 534.3963741458019 212.615715 212.615715 294.76776428341424 1339.5632 1339.5632 1870.3070528906424 11.0684;766.819 4.18343;421.048 17.0564;2662.07 0 Exp 2,1(0.5);Exp 5,1(0.5) 1.5633115014791594 3.1291136741638184 1.5021449327468872 1.6269687414169312 0.08826376156412023 1.5645568370819092 -351.6918879999999 1129.579288 -195.9115636 621.1429936 -1252.5501279999999 3931.676528 DOWN 0.0 1.0 0.0 GO:0071407 6 cellular response to organic cyclic compound 197 209 18 18 11 15 10 10 58 199 2280 0.97946 0.04779 0.067601 4.78 25671;362282;24426;25283;25315;24296;113902;114494;29221;170913 smad1;pck1;gstp1;gclc;ephx1;cyp1a1;ces1d;ccna2;arg1;abcb1a SMAD1_32578;PCK1_9439;GSTP1_8762;GCLC_8699;EPHX1_8567;CYP1A1_8415;CES1D_32914;CCNA2_8221;ARG1_33267;ABCB1A_7938 174.31902 30.6177 11.0684 262.0774411280749 184.40667814154088 258.5421487645627 98.004806 14.19431 4.18343 155.8162618187753 95.83647918569888 146.83572519104956 587.19414 80.9213 17.0564 887.2592867381555 722.6124531219367 954.3792119816572 21.9973;529.244;14.7631;131.7;39.2381;12.8863;11.0684;14.384;760.927;206.982 5.02186;356.883;9.42992;39.9158;18.9587;9.13136;4.18343;4.89199;413.607;118.025 80.1461;1021.06;25.7196;397.209;81.6965;19.3234;17.0564;58.2504;2639.93;1531.55 4 6 4 362282;24426;25315;24296 PCK1_9439;GSTP1_8762;EPHX1_8567;CYP1A1_8415 149.03287500000002 27.000600000000002 253.75818840899663 98.60074499999999 14.19431 172.24864340358474 286.94987499999996 53.70805 490.2080545625185 529.244;14.7631;39.2381;12.8863 356.883;9.42992;18.9587;9.13136 1021.06;25.7196;81.6965;19.3234 6 25671;25283;113902;114494;29221;170913 SMAD1_32578;GCLC_8699;CES1D_32914;CCNA2_8221;ARG1_33267;ABCB1A_7938 191.17645000000002 76.84864999999999 290.07551347441756 97.60751333333333 22.468829999999997 160.9330382112533 787.3569833333335 238.67755 1073.6081323355115 21.9973;131.7;11.0684;14.384;760.927;206.982 5.02186;39.9158;4.18343;4.89199;413.607;118.025 80.1461;397.209;17.0564;58.2504;2639.93;1531.55 0 Exp 2,1(0.1);Exp 4,5(0.5);Exp 5,1(0.1);Hill,1(0.1);Linear,1(0.1);Poly 2,1(0.1) 2.322189348926394 32.998013734817505 1.513624906539917 15.48720932006836 4.322050737756821 1.7903459668159485 11.881739086572708 336.75630091342737 1.428886367269783 194.5807256327302 37.26513663911612 1137.1231433608837 DOWN 0.4 0.6 0.0 GO:0010883 4 regulation of lipid storage 20 22 3 3 3 3 3 3 65 19 2460 0.99763 0.019495 0.019495 13.64 25682;113902;24232 ppard;ces1d;c3 PPARD_9536;CES1D_32914;C3_8175 113.3116 94.1074 11.0684 113.07507287337911 119.26203339130433 100.75691017883422 57.033543333333334 37.7692 4.18343 64.67126202471722 58.34623694658384 59.11426804643419 286.5858 148.485 17.0564 359.08237799775145 285.75498653416145 334.46216893020323 0.5 52.5879 1.5 164.4332 94.1074;11.0684;234.759 37.7692;4.18343;129.148 148.485;17.0564;694.216 0 3 0 3 25682;113902;24232 PPARD_9536;CES1D_32914;C3_8175 113.3116 94.1074 113.07507287337911 57.033543333333334 37.7692 64.67126202471722 286.5858 148.485 359.08237799775145 94.1074;11.0684;234.759 37.7692;4.18343;129.148 148.485;17.0564;694.216 0 Exp 5,2(0.67);Poly 2,1(0.34) 1.6961043730255754 5.112629175186157 1.5467612743377686 1.9388991594314575 0.2071657727456136 1.6269687414169312 -14.644890573680698 241.2680905736807 -16.148878922721174 130.21596558938785 -119.75416289257532 692.9257628925753 DOWN 0.0 1.0 0.0 GO:0010720 7 positive regulation of cell development 166 176 10 8 5 5 4 4 64 172 2307 0.48855 0.70328 1.0 2.27 684352;25671;361921;170913 twf2;smad1;ect2;abcb1a TWF2_10109;SMAD1_32578;ECT2_8523;ABCB1A_7938 94.348625 80.19815 10.0162 94.82156020154822 108.32482965701975 102.9487266888911 54.2693025 47.87908 3.29405 58.930517930316526 62.50584196238282 61.540588288385386 487.1479 189.65555 37.7305 705.6296908442415 650.5710197228208 797.645844285358 138.399;21.9973;10.0162;206.982 90.7363;5.02186;3.29405;118.025 299.165;80.1461;37.7305;1531.55 0 4 0 4 684352;25671;361921;170913 TWF2_10109;SMAD1_32578;ECT2_8523;ABCB1A_7938 94.348625 80.19815 94.82156020154822 54.2693025 47.87908 58.930517930316526 487.1479 189.65555 705.6296908442415 138.399;21.9973;10.0162;206.982 90.7363;5.02186;3.29405;118.025 299.165;80.1461;37.7305;1531.55 0 Exp 4,2(0.5);Poly 2,2(0.5) 1.7501642532302446 7.011186003684998 1.6358354091644287 1.8874764442443848 0.1112368666270192 1.743937075138092 1.423496002482736 187.27375399751725 -3.4826050717101964 112.0212100717102 -204.36919702735673 1178.6649970273568 DOWN 0.0 1.0 0.0 GO:0002252 3 immune effector process 125 137 11 11 6 8 5 5 63 132 2347 0.8441 0.30164 0.41169 3.65 295703;304545;245920;24854;24232 serping1;oasl;cxcl10;clu;c3 SERPING1_32597;OASL_9389;CXCL10_8408;CLU_32773;C3_8175 389.98966 234.759 32.3997 395.79609477932956 426.74059160154707 432.0598043173694 270.9225 129.148 13.7308 333.46848608102385 322.9277292761859 380.76127439501624 816.0887 694.216 99.4885 741.6162432098555 742.5045593180204 646.5168224441537 32.3997;76.6126;670.528;935.649;234.759 13.7308;28.4477;374.802;808.484;129.148 99.4885;260.389;1955.3;1071.05;694.216 0 5 0 5 295703;304545;245920;24854;24232 SERPING1_32597;OASL_9389;CXCL10_8408;CLU_32773;C3_8175 389.98966 234.759 395.79609477932956 270.9225 129.148 333.46848608102385 816.0887 694.216 741.6162432098555 32.3997;76.6126;670.528;935.649;234.759 13.7308;28.4477;374.802;808.484;129.148 99.4885;260.389;1955.3;1071.05;694.216 0 Exp 2,1(0.2);Exp 4,2(0.4);Poly 2,2(0.4) 1.70716187200148 8.566486239433289 1.5467612743377686 1.8927439451217651 0.16186845879302436 1.7183171510696411 43.059086523032136 736.920233476968 -21.37551566659579 563.2205156665958 166.03340145018046 1466.1439985498196 DOWN 0.0 1.0 0.0 GO:0090181 6 regulation of cholesterol metabolic process 18 18 2 2 2 2 2 2 66 16 2463 0.98885 0.081657 0.081657 11.11 64191;113902 dhcr7;ces1d DHCR7_8466;CES1D_32914 86.3852 86.3852 11.0684 106.51404003454194 138.5913184492714 76.77423472364467 27.546065000000002 27.546065000000002 4.18343 33.03975526977236 43.73996184767666 23.814718937246894 249.2867 249.2867 17.0564 328.4232398539726 410.2579912565301 236.72412479211053 0.0 11.0684 0.5 86.3852 161.702;11.0684 50.9087;4.18343 481.517;17.0564 0 2 0 2 64191;113902 DHCR7_8466;CES1D_32914 86.3852 86.3852 106.51404003454194 27.546065000000002 27.546065000000002 33.03975526977236 249.2867 249.2867 328.4232398539726 161.702;11.0684 50.9087;4.18343 481.517;17.0564 0 Exp 4,1(0.5);Exp 5,1(0.5) 1.707871714339785 3.419766426086426 1.6269687414169312 1.7927976846694946 0.11725877029088681 1.709883213043213 -61.235727999999995 234.006128 -18.244699599999993 73.3368296 -205.88468799999998 704.458088 DOWN 0.0 1.0 0.0 GO:0097176 5 epoxide metabolic process 2 2 1 1 1 1 1 1 67 1 2478 0.9993 0.052694 0.052694 50.0 25315 ephx1 EPHX1_8567 39.2381 39.2381 39.2381 39.2381 18.9587 18.9587 18.9587 18.9587 81.6965 81.6965 81.6965 81.69650000000001 0.0 39.2381 0.0 39.2381 39.2381 18.9587 81.6965 1 0 1 25315 EPHX1_8567 39.2381 39.2381 18.9587 18.9587 81.6965 81.6965 39.2381 18.9587 81.6965 0 0 Exp 4,1(1) 2.0484321117401123 2.0484321117401123 2.0484321117401123 2.0484321117401123 0.0 2.0484321117401123 39.2381 39.2381 18.9587 18.9587 81.6965 81.6965 UP 1.0 0.0 0.0 GO:1903037 7 regulation of leukocyte cell-cell adhesion 100 105 5 5 3 3 2 2 66 103 2376 0.46212 0.77997 1.0 1.9 24832;29221 thy1;arg1 THY1_33010;ARG1_33267 380.46350000000285 380.46350000000285 5.72311E-12 538.056641687932 464.6989612546148 524.7034627281787 206.80350000000288 206.80350000000288 5.72311E-12 292.4643144462203 252.5902527675299 285.20610401341054 1319.9650000000029 1319.9650000000029 5.72313E-12 1866.7124048577982 1612.2081734317362 1820.3854145798596 5.72311E-12;760.927 5.72311E-12;413.607 5.72313E-12;2639.93 0 2 0 2 24832;29221 THY1_33010;ARG1_33267 380.46350000000285 380.46350000000285 538.056641687932 206.80350000000288 206.80350000000288 292.4643144462203 1319.9650000000029 1319.9650000000029 1866.7124048577982 5.72311E-12;760.927 5.72311E-12;413.607 5.72313E-12;2639.93 0 Exp 2,1(0.5);Hill,1(0.5) 1.6793427237963634 3.376828908920288 1.513624906539917 1.863204002380371 0.2471897492298471 1.688414454460144 -365.24495999999147 1126.1719599999974 -198.5313599999915 612.1383599999972 -1267.1663999999912 3907.0963999999967 DOWN 0.0 1.0 0.0 GO:0097190 5 apoptotic signaling pathway 104 107 4 4 3 3 2 2 66 105 2374 0.44909 0.78895 1.0 1.87 25682;24854 ppard;clu PPARD_9536;CLU_32773 514.8782 514.8782 94.1074 595.0597720105771 512.2507284567351 595.0481703625838 423.1266 423.1266 37.7692 544.9776614408338 420.72026476360395 544.9670362241924 609.7674999999999 609.7674999999999 148.485 652.3519675853672 606.8870561998216 652.3392489338105 94.1074;935.649 37.7692;808.484 148.485;1071.05 0 2 0 2 25682;24854 PPARD_9536;CLU_32773 514.8782 514.8782 595.0597720105771 423.1266 423.1266 544.9776614408338 609.7674999999999 609.7674999999999 652.3519675853672 94.1074;935.649 37.7692;808.484 148.485;1071.05 0 Exp 5,1(0.5);Poly 2,1(0.5) 1.7362934342712018 3.493758201599121 1.5548590421676636 1.9388991594314575 0.2715573711649056 1.7468791007995605 -309.8325679999999 1339.588968 -332.173904 1178.427104 -294.34619999999984 1513.8811999999998 DOWN 0.0 1.0 0.0 GO:0045944 9 positive regulation of transcription by RNA polymerase II 241 260 16 15 11 11 9 9 59 251 2228 0.85062 0.2535 0.4137 3.46 360243;25671;25682;25154;362282;259241;316351;306575;29657 top2a;smad1;ppard;pgr;pck1;nr1d2;npas2;ckap2;arntl TOP2A_10059;SMAD1_32578;PPARD_9536;PGR_32824;PCK1_9439;NR1D2_9358;NPAS2_9350;CKAP2_8324;ARNTL_8086 124.52973333333335 32.2386 21.0878 173.4332048010487 82.39557354266485 113.36769303670137 67.3820811111111 15.2683 3.35457 116.40989745047202 37.92891381245722 72.51104035686384 372.2932111111111 114.038 43.5624 539.823169268633 256.67432066221767 418.20860668175584 86.3883;21.9973;94.1074;283.618;529.244;29.1728;21.0878;32.2386;22.9134 26.6888;5.02186;37.7692;138.711;356.883;3.35457;11.3305;15.2683;11.4115 262.273;80.1461;148.485;1554.21;1021.06;114.038;43.5624;76.7052;50.1592 2 7 2 362282;259241 PCK1_9439;NR1D2_9358 279.20840000000004 279.20840000000004 353.6037365960942 180.118785 180.118785 249.98235019523364 567.549 567.549 641.3614068853847 529.244;29.1728 356.883;3.35457 1021.06;114.038 7 360243;25671;25682;25154;316351;306575;29657 TOP2A_10059;SMAD1_32578;PPARD_9536;PGR_32824;NPAS2_9350;CKAP2_8324;ARNTL_8086 80.33582857142856 32.2386 94.9335919783704 35.171594285714285 15.2683 46.97020571265962 316.50584285714285 80.1461 551.0433617247795 86.3883;21.9973;94.1074;283.618;21.0878;32.2386;22.9134 26.6888;5.02186;37.7692;138.711;11.3305;15.2683;11.4115 262.273;80.1461;148.485;1554.21;43.5624;76.7052;50.1592 0 Exp 4,6(0.67);Exp 5,1(0.12);Linear,1(0.12);Poly 2,1(0.12) 2.0903792825305674 19.51248824596405 1.5405861139297485 3.442979335784912 0.6616470084520708 1.9603345394134521 11.22003952998152 237.83942713668517 -8.672385223197296 143.4365474454195 19.60874052227092 724.9776816999513 DOWN 0.2222222222222222 0.7777777777777778 0.0 GO:0009404 4 toxin metabolic process 12 17 2 2 2 2 2 2 66 15 2464 0.99053 0.073823 0.073823 11.76 24296;26760 cyp1a1;akr7a3 CYP1A1_8415;AKR7A3_8015 32.8218 32.8218 12.8863 28.193054472688832 30.596503104359314 28.016859708977087 10.769680000000001 10.769680000000001 9.13136 2.3169343635070763 10.586802800528401 2.302454495669102 118.1052 118.1052 19.3234 139.69856127562662 107.07869788639366 138.8255038699924 0.0 12.8863 0.5 32.8218 12.8863;52.7573 9.13136;12.408 19.3234;216.887 2 0 2 24296;26760 CYP1A1_8415;AKR7A3_8015 32.8218 32.8218 28.193054472688832 10.769680000000001 10.769680000000001 2.3169343635070763 118.1052 118.1052 139.69856127562662 12.8863;52.7573 9.13136;12.408 19.3234;216.887 0 0 Exp 4,1(0.5);Hill,1(0.5) 4.908928856506827 17.04317605495453 1.5559667348861694 15.48720932006836 9.850876102337136 8.521588027477264 -6.251779999999997 71.89538 7.558572800000002 13.9807872 -75.507128 311.717528 UP 1.0 0.0 0.0 GO:1901700 4 response to oxygen-containing compound 599 638 45 43 28 30 21 21 47 617 1862 0.89547 0.16235 0.25847 3.29 116669;684352;25682;25154;362282;24314;81687;24426;25283;361921;312495;24296;245920;84032;113902;114494;24232;25612;29221;24646;170913 vwf;twf2;ppard;pgr;pck1;nqo1;mmp9;gstp1;gclc;ect2;cyp26b1;cyp1a1;cxcl10;col3a1;ces1d;ccna2;c3;asns;arg1;abcb1b;abcb1a VWF_32396;TWF2_10109;PPARD_9536;PGR_32824;PCK1_9439;NQO1_33055;MMP9_32531;GSTP1_8762;GCLC_8699;ECT2_8523;CYP26B1_8418;CYP1A1_8415;CXCL10_8408;COL3A1_8354;CES1D_32914;CCNA2_8221;C3_8175;ASNS_8091;ARG1_33267;ABCB1B_7939;ABCB1A_7938 206.18025714285713 131.7 10.0162 250.4548627028403 171.4987225769834 241.70306327565484 116.05552761904762 39.9158 3.29405 148.53625865344418 93.80648508172118 142.64755495726877 701.5885714285714 299.165 17.0564 828.7961727654183 599.437411932545 815.660623289348 19.6764;138.399;94.1074;283.618;529.244;25.6813;728.316;14.7631;131.7;10.0162;18.1872;12.8863;670.528;212.603;11.0684;14.384;234.759;191.145;760.927;20.7941;206.982 4.11644;90.7363;37.7692;138.711;356.883;7.73944;443.137;9.42992;39.9158;3.29405;10.0176;9.13136;374.802;119.81;4.18343;4.89199;129.148;113.564;413.607;8.25355;118.025 94.078;299.165;148.485;1554.21;1021.06;86.1211;2039.06;25.7196;397.209;37.7305;36.7271;19.3234;1955.3;1510.69;17.0564;58.2504;694.216;510.267;2639.93;57.2115;1531.55 5 16 5 362282;24314;24426;312495;24296 PCK1_9439;NQO1_33055;GSTP1_8762;CYP26B1_8418;CYP1A1_8415 120.15238 18.1872 228.7414198940083 78.640264 9.42992 155.5446691845956 237.79023999999998 36.7271 438.6465398686771 529.244;25.6813;14.7631;18.1872;12.8863 356.883;7.73944;9.42992;10.0176;9.13136 1021.06;86.1211;25.7196;36.7271;19.3234 16 116669;684352;25682;25154;81687;25283;361921;245920;84032;113902;114494;24232;25612;29221;24646;170913 VWF_32396;TWF2_10109;PPARD_9536;PGR_32824;MMP9_32531;GCLC_8699;ECT2_8523;CXCL10_8408;COL3A1_8354;CES1D_32914;CCNA2_8221;C3_8175;ASNS_8091;ARG1_33267;ABCB1B_7939;ABCB1A_7938 233.06396875 164.772 257.77179764338257 127.74779749999999 102.15015 149.50963618673714 846.52555 453.738 877.7534455171636 19.6764;138.399;94.1074;283.618;728.316;131.7;10.0162;670.528;212.603;11.0684;14.384;234.759;191.145;760.927;20.7941;206.982 4.11644;90.7363;37.7692;138.711;443.137;39.9158;3.29405;374.802;119.81;4.18343;4.89199;129.148;113.564;413.607;8.25355;118.025 94.078;299.165;148.485;1554.21;2039.06;397.209;37.7305;1955.3;1510.69;17.0564;58.2504;694.216;510.267;2639.93;57.2115;1531.55 0 Exp 2,2(0.1);Exp 4,5(0.24);Exp 5,2(0.1);Hill,4(0.2);Linear,2(0.1);Poly 2,6(0.29) 2.1698293207242565 57.58203065395355 1.513624906539917 15.48720932006836 3.096571693919331 1.8538048267364502 99.05894293567363 313.3015713500407 52.5255204047192 179.58553483337602 347.10659300576344 1056.0705498513792 DOWN 0.23809523809523808 0.7619047619047619 0.0 GO:0001710 6 mesodermal cell fate commitment 1 1 1 1 1 1 1 1 67 0 2479 1.0 0.026698 0.026698 100.0 25671 smad1 SMAD1_32578 21.9973 21.9973 21.9973 21.9973 5.02186 5.02186 5.02186 5.02186 80.1461 80.1461 80.1461 80.1461 0.0 21.9973 0.0 21.9973 21.9973 5.02186 80.1461 0 1 0 1 25671 SMAD1_32578 21.9973 21.9973 5.02186 5.02186 80.1461 80.1461 21.9973 5.02186 80.1461 0 Exp 4,1(1) 1.6932154893875122 1.6932154893875122 1.6932154893875122 1.6932154893875122 0.0 1.6932154893875122 21.9973 21.9973 5.02186 5.02186 80.1461 80.1461 DOWN 0.0 1.0 0.0 GO:0046223 6 aflatoxin catabolic process 2 3 1 1 1 1 1 1 67 2 2477 0.99793 0.078005 0.078005 33.33 26760 akr7a3 AKR7A3_8015 52.7573 52.7573 52.7573 52.7573 12.408 12.408 12.408 12.408 216.887 216.887 216.887 216.887 0.0 52.7573 0.0 52.7573 52.7573 12.408 216.887 1 0 1 26760 AKR7A3_8015 52.7573 52.7573 12.408 12.408 216.887 216.887 52.7573 12.408 216.887 0 0 Hill,1(1) 1.5559667348861694 1.5559667348861694 1.5559667348861694 1.5559667348861694 0.0 1.5559667348861694 52.7573 52.7573 12.408 12.408 216.887 216.887 UP 1.0 0.0 0.0 GO:1901377 6 organic heteropentacyclic compound catabolic process 2 3 1 1 1 1 1 1 67 2 2477 0.99793 0.078005 0.078005 33.33 26760 akr7a3 AKR7A3_8015 52.7573 52.7573 52.7573 52.7573 12.408 12.408 12.408 12.408 216.887 216.887 216.887 216.887 0.0 52.7573 0.0 52.7573 52.7573 12.408 216.887 1 0 1 26760 AKR7A3_8015 52.7573 52.7573 12.408 12.408 216.887 216.887 52.7573 12.408 216.887 0 0 Hill,1(1) 1.5559667348861694 1.5559667348861694 1.5559667348861694 1.5559667348861694 0.0 1.5559667348861694 52.7573 52.7573 12.408 12.408 216.887 216.887 UP 1.0 0.0 0.0 GO:0010770 8 positive regulation of cell morphogenesis involved in differentiation 40 44 4 4 2 3 2 2 66 42 2437 0.88892 0.32953 0.32953 4.55 684352;25671 twf2;smad1 TWF2_10109;SMAD1_32578 80.19815 80.19815 21.9973 82.30843141164216 106.9251119654125 73.11646114004552 47.87908 47.87908 5.02186 60.60926176960744 67.55994873101193 53.84059271815414 189.65555 189.65555 80.1461 154.86974939801837 239.944418719327 137.57433861176864 138.399;21.9973 90.7363;5.02186 299.165;80.1461 0 2 0 2 684352;25671 TWF2_10109;SMAD1_32578 80.19815 80.19815 82.30843141164216 47.87908 47.87908 60.60926176960744 189.65555 189.65555 154.86974939801837 138.399;21.9973 90.7363;5.02186 299.165;80.1461 0 Exp 4,1(0.5);Poly 2,1(0.5) 1.7431993124081222 3.487874150276184 1.6932154893875122 1.7946586608886719 0.07173115447353992 1.743937075138092 -33.875516000000005 194.271816 -36.12107119999999 131.8792312 -24.98297199999999 404.294072 DOWN 0.0 1.0 0.0 GO:0007229 6 integrin-mediated signaling pathway 28 29 4 4 3 4 3 3 65 26 2453 0.99333 0.040526 0.040526 10.34 24832;309186;84032 thy1;fermt3;col3a1 THY1_33010;FERMT3_32542;COL3A1_8354 250.57200000000194 212.603 5.72311E-12 271.55467297212647 250.0144368741858 281.77117104836674 151.35266666666857 119.81 5.72311E-12 169.34177346813297 151.662348498043 175.485931906207 899.5166666666686 1187.86 5.72313E-12 795.551681183145 841.381143883328 800.7413661395453 0.5 106.30150000000286 1.5 375.85800000000006 5.72311E-12;539.113;212.603 5.72311E-12;334.248;119.81 5.72313E-12;1187.86;1510.69 0 3 0 3 24832;309186;84032 THY1_33010;FERMT3_32542;COL3A1_8354 250.57200000000194 212.603 271.55467297212647 151.35266666666857 119.81 169.34177346813297 899.5166666666686 1187.86 795.551681183145 5.72311E-12;539.113;212.603 5.72311E-12;334.248;119.81 5.72313E-12;1187.86;1510.69 0 Exp 2,1(0.34);Hill,1(0.34);Poly 2,1(0.34) 1.7122540419724106 5.146563529968262 1.6129854917526245 1.863204002380371 0.13107640523150313 1.6703740358352661 -56.7210405387078 557.8650405387117 -40.27558958720681 342.98092292054395 -0.7348088126138919 1799.7681421459508 DOWN 0.0 1.0 0.0 GO:0002820 7 negative regulation of adaptive immune response 15 15 3 3 3 2 2 2 66 13 2466 0.99342 0.058963 0.058963 13.33 29221;81639 arg1;alox15 ARG1_33267;ALOX15_8036 763.873 763.873 760.927 4.166273154710279 763.7918335273574 4.1646915861144596 417.3275 417.3275 413.607 5.261581558806917 417.2249949553745 5.259584197596581 2651.0 2651.0 2639.93 15.655344135476254 2650.6950058207217 15.649401173960047 0.0 760.927 0.5 763.873 760.927;766.819 413.607;421.048 2639.93;2662.07 0 2 0 2 29221;81639 ARG1_33267;ALOX15_8036 763.873 763.873 4.166273154710279 417.3275 417.3275 5.261581558806917 2651.0 2651.0 15.655344135476254 760.927;766.819 413.607;421.048 2639.93;2662.07 0 Exp 2,2(1) 1.5078739945494177 3.015769839286804 1.5021449327468872 1.513624906539917 0.008117567316895212 1.507884919643402 758.0988400000001 769.64716 410.03532 424.61967999999996 2629.3027999999995 2672.6972000000005 DOWN 0.0 1.0 0.0 GO:0048512 4 circadian behavior 13 13 4 4 3 3 2 2 66 11 2468 0.9957 0.04532 0.04532 15.38 259241;316351 nr1d2;npas2 NR1D2_9358;NPAS2_9350 25.1303 25.1303 21.0878 5.716958325893235 24.75784870971085 5.692641967726777 7.342535 7.342535 3.35457 5.639834189269223 7.709961768058866 5.615845868849823 78.80019999999999 78.80019999999999 43.5624 49.83377466819066 75.55360406259716 49.621813019260735 0.0 21.0878 0.5 25.1303 29.1728;21.0878 3.35457;11.3305 114.038;43.5624 1 1 1 259241 NR1D2_9358 29.1728 29.1728 3.35457 3.35457 114.038 114.038 29.1728 3.35457 114.038 1 316351 NPAS2_9350 21.0878 21.0878 11.3305 11.3305 43.5624 43.5624 21.0878 11.3305 43.5624 0 Exp 4,2(1) 2.5945077198054656 5.266844272613525 2.1823768615722656 3.0844674110412598 0.6378743447738244 2.6334221363067627 17.207 33.053599999999996 -0.4738764 15.1589464 9.734111999999996 147.866288 CONFLICT 0.5 0.5 0.0 GO:0051252 6 regulation of RNA metabolic process 500 535 28 26 19 17 13 13 55 522 1957 0.41699 0.69764 0.76501 2.43 360243;25671;25682;25154;362282;304545;259241;316351;25283;24854;306575;114494;29657 top2a;smad1;ppard;pgr;pck1;oasl;nr1d2;npas2;gclc;clu;ckap2;ccna2;arntl TOP2A_10059;SMAD1_32578;PPARD_9536;PGR_32824;PCK1_9439;OASL_9389;NR1D2_9358;NPAS2_9350;GCLC_8699;CLU_32773;CKAP2_8324;CCNA2_8221;ARNTL_8086 175.3164 76.6126 14.384 270.72370791030045 143.34756973524014 246.3240667740308 114.47524769230769 26.6888 3.35457 230.033783694828 89.11139363031745 214.68169551434644 395.19517692307693 148.485 43.5624 493.66665696334707 315.95649449764676 402.72436984607384 86.3883;21.9973;94.1074;283.618;529.244;76.6126;29.1728;21.0878;131.7;935.649;32.2386;14.384;22.9134 26.6888;5.02186;37.7692;138.711;356.883;28.4477;3.35457;11.3305;39.9158;808.484;15.2683;4.89199;11.4115 262.273;80.1461;148.485;1554.21;1021.06;260.389;114.038;43.5624;397.209;1071.05;76.7052;58.2504;50.1592 2 11 2 362282;259241 PCK1_9439;NR1D2_9358 279.20840000000004 279.20840000000004 353.6037365960942 180.118785 180.118785 249.98235019523364 567.549 567.549 641.3614068853847 529.244;29.1728 356.883;3.35457 1021.06;114.038 11 360243;25671;25682;25154;304545;316351;25283;24854;306575;114494;29657 TOP2A_10059;SMAD1_32578;PPARD_9536;PGR_32824;OASL_9389;NPAS2_9350;GCLC_8699;CLU_32773;CKAP2_8324;CCNA2_8221;ARNTL_8086 156.42694545454543 76.6126 269.9904235358038 102.5400590909091 26.6888 237.13081628193783 363.85811818181816 148.485 494.2593408031715 86.3883;21.9973;94.1074;283.618;76.6126;21.0878;131.7;935.649;32.2386;14.384;22.9134 26.6888;5.02186;37.7692;138.711;28.4477;11.3305;39.9158;808.484;15.2683;4.89199;11.4115 262.273;80.1461;148.485;1554.21;260.389;43.5624;397.209;1071.05;76.7052;58.2504;50.1592 0 Exp 4,8(0.62);Exp 5,1(0.08);Hill,1(0.08);Linear,1(0.08);Poly 2,2(0.16) 1.9803482273239001 26.561575531959534 1.5405861139297485 3.442979335784912 0.583217512210539 1.9388991594314575 28.14931597734801 322.48348402265196 -10.572541562566244 239.52303694718165 126.83492526540391 663.55542858075 DOWN 0.15384615384615385 0.8461538461538461 0.0 GO:0051094 5 positive regulation of developmental process 376 396 28 26 16 18 12 12 56 384 2095 0.75014 0.36406 0.61119 3.03 684352;25671;25682;81687;81919;361921;312495;24854;29397;24232;29657;170913 twf2;smad1;ppard;mmp9;fut1;ect2;cyp26b1;clu;ccl11;c3;arntl;abcb1a TWF2_10109;SMAD1_32578;PPARD_9536;MMP9_32531;FUT1_8668;ECT2_8523;CYP26B1_8418;CLU_32773;CCL11_33230;C3_8175;ARNTL_8086;ABCB1A_7938 303.22195833333336 172.6905 10.0162 364.45642222629044 332.9995684207637 363.14286875668586 190.74925916666666 84.85445 3.29405 263.8776707630703 202.33244851045137 257.65553519383815 755.5849083333334 496.69050000000004 36.7271 803.4285384857826 900.7285239466269 832.1001812136228 138.399;21.9973;94.1074;728.316;240.861;10.0162;18.1872;935.649;986.476;234.759;22.9134;206.982 90.7363;5.02186;37.7692;443.137;78.9726;3.29405;10.0176;808.484;552.974;129.148;11.4115;118.025 299.165;80.1461;148.485;2039.06;847.87;37.7305;36.7271;1071.05;2230.86;694.216;50.1592;1531.55 2 10 2 312495;29397 CYP26B1_8418;CCL11_33230 502.3316 502.3316 684.6835766269847 281.49580000000003 281.49580000000003 383.9281523286356 1133.79355 1133.79355 1551.486252414505 18.1872;986.476 10.0176;552.974 36.7271;2230.86 10 684352;25671;25682;81687;81919;361921;24854;24232;29657;170913 TWF2_10109;SMAD1_32578;PPARD_9536;MMP9_32531;FUT1_8668;ECT2_8523;CLU_32773;C3_8175;ARNTL_8086;ABCB1A_7938 263.40003 172.6905 315.7309969733449 172.599951 84.85445 257.9364708680066 679.94318 496.69050000000004 695.2267196662439 138.399;21.9973;94.1074;728.316;240.861;10.0162;935.649;234.759;22.9134;206.982 90.7363;5.02186;37.7692;443.137;78.9726;3.29405;808.484;129.148;11.4115;118.025 299.165;80.1461;148.485;2039.06;847.87;37.7305;1071.05;694.216;50.1592;1531.55 0 Exp 2,1(0.09);Exp 4,4(0.34);Exp 5,1(0.09);Linear,1(0.09);Poly 2,4(0.34);Power,1(0.09) 1.9741037501774044 24.354853630065918 1.5467612743377686 3.442979335784912 0.5489565139686653 1.9131878018379211 97.01132512270135 509.43259154396526 41.44641180344044 340.05210652989285 301.00241902332687 1210.1673976433397 DOWN 0.16666666666666666 0.8333333333333334 0.0 GO:0042398 6 cellular modified amino acid biosynthetic process 19 20 3 3 3 3 3 3 65 17 2462 0.99837 0.01499 0.01499 15.0 288583;156275;25283 plod3;ggt7;gclc PLOD3_9507;GGT7_33026;GCLC_8699 374.646 131.7 109.609 440.0648239600615 219.3054334657398 306.4572460545811 231.64213333333336 39.9158 29.3336 341.2852221397424 110.00462620229821 238.13588663381427 616.434 397.209 346.073 424.7641241571609 471.92060831323596 293.9766687118327 0.0 109.609 1.0 131.7 882.629;109.609;131.7 625.677;29.3336;39.9158 1106.02;346.073;397.209 0 3 0 3 288583;156275;25283 PLOD3_9507;GGT7_33026;GCLC_8699 374.646 131.7 440.0648239600615 231.64213333333336 39.9158 341.2852221397424 616.434 397.209 424.7641241571609 882.629;109.609;131.7 625.677;29.3336;39.9158 1106.02;346.073;397.209 0 Exp 4,1(0.34);Hill,1(0.34);Poly 2,1(0.34) 1.870348437603909 5.621543884277344 1.7160688638687134 1.9746891260147095 0.13839276049031324 1.930785894393921 -123.33422736548454 872.6262273654845 -154.55845181739681 617.8427184840634 135.76814440850433 1097.0998555914957 DOWN 0.0 1.0 0.0 GO:0044283 4 small molecule biosynthetic process 144 161 12 12 11 10 10 10 58 151 2328 0.997 0.009183 0.009183 6.21 288583;362282;24426;25315;64191;312495;24296;113902;25612;81639 plod3;pck1;gstp1;ephx1;dhcr7;cyp26b1;cyp1a1;ces1d;asns;alox15 PLOD3_9507;PCK1_9439;GSTP1_8762;EPHX1_8567;DHCR7_8466;CYP26B1_8418;CYP1A1_8415;CES1D_32914;ASNS_8091;ALOX15_8036 262.76821 100.47005 11.0684 336.9362099145556 215.3970973584464 287.01967319581365 161.980171 34.9337 4.18343 223.57720839180874 119.0572829232569 179.38071814021117 596.1457 281.60675 17.0564 836.6695574699355 588.7736299040712 853.9972445154658 7.5 648.0315 882.629;529.244;14.7631;39.2381;161.702;18.1872;12.8863;11.0684;191.145;766.819 625.677;356.883;9.42992;18.9587;50.9087;10.0176;9.13136;4.18343;113.564;421.048 1106.02;1021.06;25.7196;81.6965;481.517;36.7271;19.3234;17.0564;510.267;2662.07 5 5 5 362282;24426;25315;312495;24296 PCK1_9439;GSTP1_8762;EPHX1_8567;CYP26B1_8418;CYP1A1_8415 122.86374 18.1872 227.41818698534868 80.88411599999999 10.0176 154.34244743880305 236.90532 36.7271 439.033301691588 529.244;14.7631;39.2381;18.1872;12.8863 356.883;9.42992;18.9587;10.0176;9.13136 1021.06;25.7196;81.6965;36.7271;19.3234 5 288583;64191;113902;25612;81639 PLOD3_9507;DHCR7_8466;CES1D_32914;ASNS_8091;ALOX15_8036 402.67267999999996 191.145 393.4225945524888 243.076226 113.564 268.7139963414818 955.38608 510.267 1029.3937620476104 882.629;161.702;11.0684;191.145;766.819 625.677;50.9087;4.18343;113.564;421.048 1106.02;481.517;17.0564;510.267;2662.07 0 Exp 2,1(0.1);Exp 4,5(0.5);Exp 5,1(0.1);Linear,1(0.1);Poly 2,2(0.2) 2.349143382141425 33.20894014835358 1.5021449327468872 15.48720932006836 4.314092077428088 1.7990894317626953 53.932983495137904 471.6034365048621 23.40558156163553 300.5547604383645 77.57253569609236 1114.7188643039076 CONFLICT 0.5 0.5 0.0 GO:0097755 7 positive regulation of blood vessel diameter 27 28 4 4 3 3 2 2 66 26 2453 0.96298 0.17069 0.17069 7.14 25682;288583 ppard;plod3 PPARD_9536;PLOD3_9507 488.3682 488.3682 94.1074 557.5689704720663 336.6656052613118 514.6414308354688 331.7231 331.7231 37.7692 415.71359209246464 218.6163205191161 383.7075755329121 627.2525 627.2525 148.485 677.0794917234607 443.03364784286214 624.9507717671154 0.5 488.3682 94.1074;882.629 37.7692;625.677 148.485;1106.02 0 2 0 2 25682;288583 PPARD_9536;PLOD3_9507 488.3682 488.3682 557.5689704720663 331.7231 331.7231 415.71359209246464 627.2525 627.2525 677.0794917234607 94.1074;882.629 37.7692;625.677 148.485;1106.02 0 Exp 5,1(0.5);Poly 2,1(0.5) 1.8240845588079366 3.654968023300171 1.7160688638687134 1.9388991594314575 0.15756481304621903 1.8274840116500854 -284.382968 1261.1193680000001 -244.42654399999992 907.872744 -311.13179999999966 1565.6367999999998 DOWN 0.0 1.0 0.0 GO:0001906 3 cell killing 31 37 4 4 3 3 3 3 65 34 2445 0.98419 0.074193 0.074193 8.11 245920;29397;24232 cxcl10;ccl11;c3 CXCL10_8408;CCL11_33230;C3_8175 630.5876666666667 670.528 234.759 377.4467309334303 724.666554289004 398.28064733380666 352.308 374.802 129.148 212.8064956621392 405.3569858376511 224.5560838569684 1626.7920000000001 1955.3 694.216 819.3026456883925 1756.217877720207 819.0730469944484 0.5 452.6435 670.528;986.476;234.759 374.802;552.974;129.148 1955.3;2230.86;694.216 1 2 1 29397 CCL11_33230 986.476 986.476 552.974 552.974 2230.86 2230.86 986.476 552.974 2230.86 2 245920;24232 CXCL10_8408;C3_8175 452.6435 452.6435 308.13521493088064 251.97500000000002 251.97500000000002 173.7036092256002 1324.758 1324.758 891.7210480458558 670.528;234.759 374.802;129.148 1955.3;694.216 0 Exp 2,1(0.34);Poly 2,1(0.34);Power,1(0.34) 1.7844001199236552 5.3820449113845825 1.5467612743377686 1.9814788103103638 0.22344116497537578 1.8538048267364502 203.46648211671265 1057.7088512166206 111.4947803905597 593.1212196094405 699.6637780495063 2553.9202219504937 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0042730 7 fibrinolysis 12 12 2 2 2 2 2 2 66 10 2469 0.99663 0.039009 0.039009 16.67 295703;24367 serping1;fgg SERPING1_32597;FGG_8639 37.43045 37.43045 32.3997 7.114554878908428 39.26732745195658 6.623341571894576 17.1866 17.1866 13.7308 4.887239228848936 18.448416050980782 4.54980744504361 98.77095 98.77095 98.0534 1.0147689416818626 98.50895101065419 0.9447058082645903 0.0 32.3997 0.5 37.43045 32.3997;42.4612 13.7308;20.6424 99.4885;98.0534 0 2 0 2 295703;24367 SERPING1_32597;FGG_8639 37.43045 37.43045 7.114554878908428 17.1866 17.1866 4.887239228848936 98.77095 98.77095 1.0147689416818626 32.3997;42.4612 13.7308;20.6424 99.4885;98.0534 0 Exp 4,2(1) 2.2003626914150454 4.535955309867859 1.7183171510696411 2.8176381587982178 0.7773373392657056 2.2679776549339294 27.570180000000008 47.29071999999999 10.413232 23.959967999999996 97.36455199999999 100.17734800000001 DOWN 0.0 1.0 0.0 GO:0043547 7 positive regulation of GTPase activity 63 68 8 7 4 5 3 3 65 65 2414 0.89408 0.27203 0.42691 4.41 24832;361921;29397 thy1;ect2;ccl11 THY1_33010;ECT2_8523;CCL11_33230 332.1640666666686 10.0162 5.72311E-12 566.672886807205 330.3031586367065 564.5023796155233 185.42268333333527 3.29405 5.72311E-12 318.31303849968157 184.13423887712716 317.30364511790606 756.1968333333352 37.7305 5.72313E-12 1277.2350954307822 753.5825062495744 1270.9764533826906 5.72311E-12;10.0162;986.476 5.72311E-12;3.29405;552.974 5.72313E-12;37.7305;2230.86 1 2 1 29397 CCL11_33230 986.476 986.476 552.974 552.974 2230.86 2230.86 986.476 552.974 2230.86 2 24832;361921 THY1_33010;ECT2_8523 5.0081000000028615 5.0081000000028615 7.0825229417166495 1.6470250000028615 1.6470250000028615 2.3292450925634998 18.86525000000286 18.86525000000286 26.67949240755499 5.72311E-12;10.0162 5.72311E-12;3.29405 5.72313E-12;37.7305 0 Exp 4,1(0.34);Hill,1(0.34);Power,1(0.34) 1.8210833143398362 5.480518221855164 1.6358354091644287 1.9814788103103638 0.17566766356181546 1.863204002380371 -309.08667106491174 973.4148043982489 -174.78242885680817 545.6277955234787 -689.1307379508473 2201.5244046175176 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0030334 6 regulation of cell migration 259 272 22 22 14 15 10 10 58 262 2217 0.89713 0.18325 0.31556 3.68 24832;25682;25154;81687;24426;81919;309186;245920;84032;29397 thy1;ppard;pgr;mmp9;gstp1;fut1;fermt3;cxcl10;col3a1;ccl11 THY1_33010;PPARD_9536;PGR_32824;MMP9_32531;GSTP1_8762;FUT1_8668;FERMT3_32542;CXCL10_8408;COL3A1_8354;CCL11_33230 377.0385500000006 262.2395 5.72311E-12 335.82012659463675 401.70501589781117 345.4041007407458 208.98537200000055 129.2605 5.72311E-12 199.70737984606387 219.79564519311737 210.56321681672256 1150.0054600000008 1349.275 5.72313E-12 855.2408200586304 1163.5174444785978 849.5568166390135 5.72311E-12;94.1074;283.618;728.316;14.7631;240.861;539.113;670.528;212.603;986.476 5.72311E-12;37.7692;138.711;443.137;9.42992;78.9726;334.248;374.802;119.81;552.974 5.72313E-12;148.485;1554.21;2039.06;25.7196;847.87;1187.86;1955.3;1510.69;2230.86 2 8 2 24426;29397 GSTP1_8762;CCL11_33230 500.61955 500.61955 687.1047809564456 281.20196000000004 281.20196000000004 384.3437048418033 1128.2898 1128.2898 1559.2697303084162 14.7631;986.476 9.42992;552.974 25.7196;2230.86 8 24832;25682;25154;81687;81919;309186;245920;84032 THY1_33010;PPARD_9536;PGR_32824;MMP9_32531;FUT1_8668;FERMT3_32542;CXCL10_8408;COL3A1_8354 346.14330000000075 262.2395 268.5098502898214 190.9312250000007 129.2605 168.26389379160722 1155.4343750000007 1349.275 770.0121266273168 5.72311E-12;94.1074;283.618;728.316;240.861;539.113;670.528;212.603 5.72311E-12;37.7692;138.711;443.137;78.9726;334.248;374.802;119.81 5.72313E-12;148.485;1554.21;2039.06;847.87;1187.86;1955.3;1510.69 0 Exp 2,3(0.3);Exp 4,1(0.1);Exp 5,1(0.1);Hill,1(0.1);Linear,1(0.1);Poly 2,2(0.2);Power,1(0.1) 2.0127351845865205 20.77787744998932 1.5405861139297485 3.5281898975372314 0.608671620778943 1.9010515809059143 168.8950791036338 585.1820208963675 85.20545557183874 332.76528842816236 619.9217078902443 1680.0892121097572 DOWN 0.2 0.8 0.0 GO:0000086 6 G2/M transition of mitotic cell cycle 16 16 3 3 3 2 2 2 66 14 2465 0.99205 0.066251 0.066251 12.5 114494;170913 ccna2;abcb1a CCNA2_8221;ABCB1A_7938 110.68299999999999 110.68299999999999 14.384 136.1873518429667 116.70416005258403 135.92088163796737 61.458495 61.458495 4.89199 79.9971185470455 64.9953539520171 79.84059264144476 794.9001999999999 794.9001999999999 58.2504 1041.7801378794281 840.959726563142 1039.7417447162723 0.0 14.384 0.5 110.68299999999999 14.384;206.982 4.89199;118.025 58.2504;1531.55 0 2 0 2 114494;170913 CCNA2_8221;ABCB1A_7938 110.68299999999999 110.68299999999999 136.1873518429667 61.458495 61.458495 79.9971185470455 794.9001999999999 794.9001999999999 1041.7801378794281 14.384;206.982 4.89199;118.025 58.2504;1531.55 0 Exp 4,1(0.5);Poly 2,1(0.5) 1.7522949432288475 3.51427161693573 1.6267951726913452 1.8874764442443848 0.18432949484348612 1.757135808467865 -78.06303999999999 299.42904 -49.41185480000001 172.3288448 -648.9334079999999 2238.733808 DOWN 0.0 1.0 0.0 GO:0034613 5 cellular protein localization 184 195 11 10 8 6 4 4 64 191 2288 0.39433 0.77777 0.81618 2.05 315852;24832;363131;29657 ttk;thy1;pik3r4;arntl TTK_32727;THY1_33010;PIK3R4_9484;ARNTL_8086 428.9731000000014 380.1322 5.72311E-12 490.36201368312754 452.66317164714036 467.455341865193 298.3161250000014 229.01825 5.72311E-12 357.86137129768747 301.5686263677756 328.04884456706895 861.8048000000015 669.5646 5.72313E-12 1022.6066368407862 1037.0796580613944 1102.7528274590995 737.351;5.72311E-12;955.628;22.9134 446.625;5.72311E-12;735.228;11.4115 2108.09;5.72313E-12;1288.97;50.1592 0 4 0 4 315852;24832;363131;29657 TTK_32727;THY1_33010;PIK3R4_9484;ARNTL_8086 428.9731000000014 380.1322 490.36201368312754 298.3161250000014 229.01825 357.86137129768747 861.8048000000015 669.5646 1022.6066368407862 737.351;5.72311E-12;955.628;22.9134 446.625;5.72311E-12;735.228;11.4115 2108.09;5.72313E-12;1288.97;50.1592 0 Exp 4,1(0.25);Hill,1(0.25);Linear,1(0.25);Poly 2,1(0.25) 1.9533663184746757 8.319203495979309 1.5018656253814697 3.442979335784912 0.9242181446757198 1.6871792674064636 -51.58167340946352 909.5278734094663 -52.3880188717323 649.0202688717352 -140.34970410396875 1863.9593041039716 DOWN 0.0 1.0 0.0 GO:0044271 5 cellular nitrogen compound biosynthetic process 201 229 10 10 8 7 7 7 61 222 2257 0.73619 0.41279 0.66647 3.06 25682;299112;300795;156275;25283;25612;29221 ppard;pole2;pclaf;ggt7;gclc;asns;arg1 PPARD_9536;POLE2_9520;NS5ATP9_9367;GGT7_33026;GCLC_8699;ASNS_8091;ARG1_33267 225.67205718165684 131.7 2.71598E-7 252.53929888156455 203.92221433465716 253.73345946055625 111.67208575308543 39.9158 2.71598E-7 142.77830616152718 100.52520526386643 142.86492976760482 671.4940000387999 397.209 2.71599E-7 895.0304581263557 626.6967452987542 894.8233328910322 94.1074;2.71598E-7;292.216;109.609;131.7;191.145;760.927 37.7692;2.71598E-7;147.515;29.3336;39.9158;113.564;413.607 148.485;2.71599E-7;658.494;346.073;397.209;510.267;2639.93 0 7 0 7 25682;299112;300795;156275;25283;25612;29221 PPARD_9536;POLE2_9520;NS5ATP9_9367;GGT7_33026;GCLC_8699;ASNS_8091;ARG1_33267 225.67205718165684 131.7 252.53929888156455 111.67208575308543 39.9158 142.77830616152718 671.4940000387999 397.209 895.0304581263557 94.1074;2.71598E-7;292.216;109.609;131.7;191.145;760.927 37.7692;2.71598E-7;147.515;29.3336;39.9158;113.564;413.607 148.485;2.71599E-7;658.494;346.073;397.209;510.267;2639.93 0 Exp 2,2(0.29);Exp 4,1(0.15);Exp 5,1(0.15);Hill,2(0.29);Poly 2,1(0.15) 1.775006207738697 12.47886872291565 1.513624906539917 1.9746891260147095 0.17676371906768112 1.805381178855896 38.58832647051199 412.7557878928018 5.900436351921655 217.44373515424923 8.44615779024673 1334.5418422873531 DOWN 0.0 1.0 0.0 GO:1904880 5 response to hydrogen sulfide 3 3 1 1 1 1 1 1 67 2 2477 0.99793 0.078005 0.078005 33.33 24314 nqo1 NQO1_33055 25.6813 25.6813 25.6813 25.6813 7.73944 7.73944 7.73944 7.73944 86.1211 86.1211 86.1211 86.1211 0.0 25.6813 0.0 25.6813 25.6813 7.73944 86.1211 1 0 1 24314 NQO1_33055 25.6813 25.6813 7.73944 7.73944 86.1211 86.1211 25.6813 7.73944 86.1211 0 0 Hill,1(1) 2.1727771759033203 2.1727771759033203 2.1727771759033203 2.1727771759033203 0.0 2.1727771759033203 25.6813 25.6813 7.73944 7.73944 86.1211 86.1211 UP 1.0 0.0 0.0 GO:0007010 6 cytoskeleton organization 170 184 13 12 7 9 4 4 64 180 2299 0.44775 0.73657 0.81536 2.17 24832;295661;29397;686019 thy1;spc25;ccl11;casq1 THY1_33010;SPC25_9925;CCL11_33230;CASQ1_32992 292.5065750000014 91.77515 5.72311E-12 466.8997401788255 237.1931476159165 405.8755852562128 165.28767500000146 54.08835 5.72311E-12 262.0217254027011 134.53276380211258 228.44721332881758 660.1597500000015 204.8895 5.72313E-12 1053.650234990205 535.6678749314925 913.4204003061274 5.72311E-12;35.8903;986.476;147.66 5.72311E-12;11.5744;552.974;96.6023 5.72313E-12;124.006;2230.86;285.773 1 3 1 29397 CCL11_33230 986.476 986.476 552.974 552.974 2230.86 2230.86 986.476 552.974 2230.86 3 24832;295661;686019 THY1_33010;SPC25_9925;CASQ1_32992 61.183433333335245 35.8903 77.0108813438918 36.058900000001906 11.5744 52.750536931009464 136.59300000000192 124.006 143.30169681130516 5.72311E-12;35.8903;147.66 5.72311E-12;11.5744;96.6023 5.72313E-12;124.006;285.773 0 Exp 4,1(0.25);Hill,1(0.25);Poly 2,1(0.25);Power,1(0.25) 1.9235051051045902 7.765112400054932 1.5933629274368286 2.327066659927368 0.3041871365344427 1.9223414063453674 -165.05517037524749 750.0683203752503 -91.49361589464573 422.0689658946486 -372.41748029039945 1692.7369802904022 DOWN 0.25 0.75 0.0 GO:0043254 6 regulation of protein-containing complex assembly 110 120 5 5 5 5 5 5 63 115 2364 0.90197 0.21447 0.25038 4.17 684352;24854;29397;246142;81639 twf2;clu;ccl11;bmf;alox15 TWF2_10109;CLU_32773;CCL11_33230;BMF_8152;ALOX15_8036 589.3488 766.819 119.401 428.1752474842514 562.7701780406808 432.2442104364561 391.01418 421.048 81.8286 311.117579198881 365.769537177252 302.8225785738898 1296.646 1071.05 220.085 1111.5286753914631 1279.8669755085095 1144.2188312427938 138.399;935.649;986.476;119.401;766.819 90.7363;808.484;552.974;81.8286;421.048 299.165;1071.05;2230.86;220.085;2662.07 1 4 1 29397 CCL11_33230 986.476 986.476 552.974 552.974 2230.86 2230.86 986.476 552.974 2230.86 4 684352;24854;246142;81639 TWF2_10109;CLU_32773;BMF_8152;ALOX15_8036 490.067 452.609 422.7681216332817 350.524225 255.89215000000002 343.69941481292807 1063.0925 685.1075 1132.9959160892859 138.399;935.649;119.401;766.819 90.7363;808.484;81.8286;421.048 299.165;1071.05;220.085;2662.07 0 Exp 2,1(0.2);Poly 2,3(0.6);Power,1(0.2) 1.67834963089174 8.436527252197266 1.5021449327468872 1.9814788103103638 0.1980729995081174 1.6033858060836792 214.03664781422776 964.6609521857722 118.30759801512204 663.720761984878 322.3481585706817 2270.9438414293186 DOWN 0.2 0.8 0.0 GO:0010041 7 response to iron(III) ion 5 6 2 2 2 2 2 2 66 4 2475 0.99966 0.0098306 0.0098306 33.33 81687;24296 mmp9;cyp1a1 MMP9_32531;CYP1A1_8415 370.60115 370.60115 12.8863 505.8851923322574 489.7212937481423 477.0121702094077 226.13418000000001 226.13418000000001 9.13136 306.8883311172075 298.3967855701971 289.3729072465442 1029.1917 1029.1917 19.3234 1428.1694460706613 1365.4809456454966 1346.6577342502976 0.0 12.8863 0.0 12.8863 728.316;12.8863 443.137;9.13136 2039.06;19.3234 1 1 1 24296 CYP1A1_8415 12.8863 12.8863 9.13136 9.13136 19.3234 19.3234 12.8863 9.13136 19.3234 1 81687 MMP9_32531 728.316 728.316 443.137 443.137 2039.06 2039.06 728.316 443.137 2039.06 0 Exp 4,1(0.5);Linear,1(0.5) 5.636455735651926 17.53855586051941 2.05134654045105 15.48720932006836 9.500589682559335 8.769277930259705 -330.5199559999999 1071.722256 -199.19134719999994 651.4597071999999 -950.1501680000001 3008.533568 CONFLICT 0.5 0.5 0.0 GO:0033365 6 protein localization to organelle 115 123 6 5 5 4 3 3 65 120 2359 0.58166 0.6472 1.0 2.44 315852;363131;29657 ttk;pik3r4;arntl TTK_32727;PIK3R4_9484;ARNTL_8086 571.9641333333334 737.351 22.9134 487.85627290489293 672.5151163285859 378.739574815251 397.75483333333335 446.625 11.4115 364.374534388153 448.03613933247016 285.36807696336336 1149.0730666666668 1288.97 50.1592 1036.0734329014585 1540.774223680046 931.8825082399609 737.351;955.628;22.9134 446.625;735.228;11.4115 2108.09;1288.97;50.1592 0 3 0 3 315852;363131;29657 TTK_32727;PIK3R4_9484;ARNTL_8086 571.9641333333334 737.351 487.85627290489293 397.75483333333335 446.625 364.374534388153 1149.0730666666668 1288.97 1036.0734329014585 737.351;955.628;22.9134 446.625;735.228;11.4115 2108.09;1288.97;50.1592 0 Exp 4,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 1.9843797681104673 6.455999493598938 1.5018656253814697 3.442979335784912 1.1180306936274 1.5111545324325562 19.90279037785797 1124.025476288809 -14.573768275762177 810.083434942429 -23.35439308965192 2321.500526422986 DOWN 0.0 1.0 0.0 GO:0046903 5 secretion 115 123 7 7 4 6 3 3 65 120 2359 0.58166 0.6472 1.0 2.44 24367;24646;170913 fgg;abcb1b;abcb1a FGG_8639;ABCB1B_7939;ABCB1A_7938 90.0791 42.4612 20.7941 101.81886773535639 79.36826656849583 98.10604862973886 48.97365 20.6424 8.25355 60.12019297787974 42.672873593486074 57.90567589656706 562.2716333333333 98.0534 57.2115 839.6680470667579 482.2209835419464 801.8035065785285 42.4612;20.7941;206.982 20.6424;8.25355;118.025 98.0534;57.2115;1531.55 0 3 0 3 24367;24646;170913 FGG_8639;ABCB1B_7939;ABCB1A_7938 90.0791 42.4612 101.81886773535639 48.97365 20.6424 60.12019297787974 562.2716333333333 98.0534 839.6680470667579 42.4612;20.7941;206.982 20.6424;8.25355;118.025 98.0534;57.2115;1531.55 0 Exp 4,1(0.34);Hill,1(0.34);Poly 2,1(0.34) 3.2051078202152588 10.896119832992554 1.8874764442443848 6.191005229949951 2.2644044920371806 2.8176381587982178 -25.139795363358203 205.2979953633582 -19.058752815041792 117.00605281504178 -387.90220975435 1512.4454764210166 DOWN 0.0 1.0 0.0 GO:0097327 5 response to antineoplastic agent 75 80 9 9 5 9 5 5 63 75 2404 0.98157 0.060122 0.060122 6.25 362282;25612;29221;24646;170913 pck1;asns;arg1;abcb1b;abcb1a PCK1_9439;ASNS_8091;ARG1_33267;ABCB1B_7939;ABCB1A_7938 341.81842 206.982 20.7941 297.79200104784877 254.41817475083062 292.94339916119645 202.06651000000002 118.025 8.25355 174.05218874571932 143.55211256356364 163.46677147276375 1152.0037 1021.06 57.2115 998.1886437383465 987.4846996406536 1057.0527272598752 3.0 529.244 529.244;191.145;760.927;20.7941;206.982 356.883;113.564;413.607;8.25355;118.025 1021.06;510.267;2639.93;57.2115;1531.55 1 4 1 362282 PCK1_9439 529.244 529.244 356.883 356.883 1021.06 1021.06 529.244 356.883 1021.06 4 25612;29221;24646;170913 ASNS_8091;ARG1_33267;ABCB1B_7939;ABCB1A_7938 294.96202500000004 199.0635 321.8746487399546 163.3623875 115.7945 174.37170609438704 1184.739625 1020.9085 1149.5056123163974 191.145;760.927;20.7941;206.982 113.564;413.607;8.25355;118.025 510.267;2639.93;57.2115;1531.55 0 Exp 2,1(0.2);Hill,1(0.2);Linear,1(0.2);Poly 2,2(0.4) 2.19931443377214 13.00890028476715 1.513624906539917 6.191005229949951 2.0119597191547163 1.805381178855896 80.79222226051797 602.844617739482 49.50303993812352 354.6299800618765 277.05277658723287 2026.9546234127665 DOWN 0.2 0.8 0.0 GO:0010556 6 regulation of macromolecule biosynthetic process 567 609 33 30 19 19 13 13 55 596 1883 0.21592 0.86188 0.39016 2.13 360243;25671;25682;25154;362282;259241;316351;24426;25283;24854;306575;114494;29657 top2a;smad1;ppard;pgr;pck1;nr1d2;npas2;gstp1;gclc;clu;ckap2;ccna2;arntl TOP2A_10059;SMAD1_32578;PPARD_9536;PGR_32824;PCK1_9439;NR1D2_9358;NPAS2_9350;GSTP1_8762;GCLC_8699;CLU_32773;CKAP2_8324;CCNA2_8221;ARNTL_8086 170.55874615384616 32.2386 14.384 273.13558534656255 138.1607966976538 244.8567066226174 113.01234153846154 15.2683 3.35457 230.6860168374871 86.49011202886233 212.52532102521758 377.14368461538464 114.038 25.7196 503.20510911766695 301.3302206551571 403.53539654898447 86.3883;21.9973;94.1074;283.618;529.244;29.1728;21.0878;14.7631;131.7;935.649;32.2386;14.384;22.9134 26.6888;5.02186;37.7692;138.711;356.883;3.35457;11.3305;9.42992;39.9158;808.484;15.2683;4.89199;11.4115 262.273;80.1461;148.485;1554.21;1021.06;114.038;43.5624;25.7196;397.209;1071.05;76.7052;58.2504;50.1592 3 10 3 362282;259241;24426 PCK1_9439;NR1D2_9358;GSTP1_8762 191.05996666666667 29.1728 292.9645715179966 123.22249666666666 9.42992 202.3787305595517 386.93919999999997 114.038 550.9373164790346 529.244;29.1728;14.7631 356.883;3.35457;9.42992 1021.06;114.038;25.7196 10 360243;25671;25682;25154;316351;25283;24854;306575;114494;29657 TOP2A_10059;SMAD1_32578;PPARD_9536;PGR_32824;NPAS2_9350;GCLC_8699;CLU_32773;CKAP2_8324;CCNA2_8221;ARNTL_8086 164.40838 59.31345 283.2236896275247 109.949295 20.97855 248.6120571989307 374.20502999999997 114.31555 519.7378094826918 86.3883;21.9973;94.1074;283.618;21.0878;131.7;935.649;32.2386;14.384;22.9134 26.6888;5.02186;37.7692;138.711;11.3305;39.9158;808.484;15.2683;4.89199;11.4115 262.273;80.1461;148.485;1554.21;43.5624;397.209;1071.05;76.7052;58.2504;50.1592 0 Exp 4,8(0.62);Exp 5,1(0.08);Hill,1(0.08);Linear,1(0.08);Poly 2,2(0.16) 2.0775246527154345 28.197021484375 1.5405861139297485 3.5281898975372314 0.7105473972267503 1.9603345394134521 22.08055062177175 319.0369416859206 -12.390005691585628 238.41468876850877 103.59827130165911 650.6890979291101 DOWN 0.23076923076923078 0.7692307692307693 0.0 GO:0022411 5 cellular component disassembly 46 49 3 3 3 2 2 2 66 47 2432 0.85905 0.37853 0.37853 4.08 684352;24232 twf2;c3 TWF2_10109;C3_8175 186.579 186.579 138.399 68.13680943513565 180.55432972972974 67.60200807867345 109.94215 109.94215 90.7363 27.161173546903342 107.54055362162161 26.947987273926813 496.69050000000004 496.69050000000004 299.165 279.3432410145267 471.990914954955 277.1506942039027 138.399;234.759 90.7363;129.148 299.165;694.216 0 2 0 2 684352;24232 TWF2_10109;C3_8175 186.579 186.579 68.13680943513565 109.94215 109.94215 27.161173546903342 496.69050000000004 496.69050000000004 279.3432410145267 138.399;234.759 90.7363;129.148 299.165;694.216 0 Poly 2,2(1) 1.6661057941551838 3.3414199352264404 1.5467612743377686 1.7946586608886719 0.17528992306856658 1.6707099676132202 92.14620000000004 281.0118 72.29868400000001 147.585616 109.54052000000013 883.84048 DOWN 0.0 1.0 0.0 GO:0030324 5 lung development 38 42 2 2 2 2 2 2 66 40 2439 0.9001 0.30964 0.30964 4.76 64191;29221 dhcr7;arg1 DHCR7_8466;ARG1_33267 461.3145 461.3145 161.702 423.716060956509 380.0667973577375 407.83933349201254 232.25785000000002 232.25785000000002 50.9087 256.4664274548328 183.0803229821785 246.85657796434728 1560.7234999999998 1560.7234999999998 481.517 1526.2284689011997 1268.0686581572968 1469.0403760198515 161.702;760.927 50.9087;413.607 481.517;2639.93 0 2 0 2 64191;29221 DHCR7_8466;ARG1_33267 461.3145 461.3145 423.716060956509 232.25785000000002 232.25785000000002 256.4664274548328 1560.7234999999998 1560.7234999999998 1526.2284689011997 161.702;760.927 50.9087;413.607 481.517;2639.93 0 Exp 2,1(0.5);Exp 4,1(0.5) 1.6473078728345967 3.3064225912094116 1.513624906539917 1.7927976846694946 0.19740496453811182 1.6532112956047058 -125.92599999999999 1048.555 -123.18648399999995 587.702184 -554.5212399999996 3675.9682399999997 DOWN 0.0 1.0 0.0 GO:2000425 7 regulation of apoptotic cell clearance 5 6 3 3 2 3 2 2 66 4 2475 0.99966 0.0098306 0.0098306 33.33 24232;81639 c3;alox15 C3_8175;ALOX15_8036 500.789 500.789 234.759 376.2232339981143 593.1843655913977 352.8032236735713 275.098 275.098 129.148 206.4044694283532 325.7881612903226 193.55572865901476 1678.143 1678.143 694.216 1391.4829077850723 2019.8724849462365 1304.8626751098222 0.0 234.759 0.0 234.759 234.759;766.819 129.148;421.048 694.216;2662.07 0 2 0 2 24232;81639 C3_8175;ALOX15_8036 500.789 500.789 376.2232339981143 275.098 275.098 206.4044694283532 1678.143 1678.143 1391.4829077850723 234.759;766.819 129.148;421.048 694.216;2662.07 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.5242898708630181 3.0489062070846558 1.5021449327468872 1.5467612743377686 0.0315485176906476 1.5244531035423279 -20.629799999999932 1022.2077999999999 -10.963999999999942 561.1599999999999 -250.35392000000002 3606.63992 DOWN 0.0 1.0 0.0 GO:0051258 8 protein polymerization 20 21 3 3 2 3 2 2 66 19 2460 0.98284 0.10656 0.10656 9.52 24367;686019 fgg;casq1 FGG_8639;CASQ1_32992 95.0606 95.0606 42.4612 74.38678485268738 102.85213532993664 73.56614516966813 58.62235 58.62235 20.6424 53.71176038825204 64.24831003479558 53.11920887380351 191.91320000000002 191.91320000000002 98.0534 132.73780212162626 205.81662756306702 131.273430350841 0.5 95.0606 42.4612;147.66 20.6424;96.6023 98.0534;285.773 0 2 0 2 24367;686019 FGG_8639;CASQ1_32992 95.0606 95.0606 74.38678485268738 58.62235 58.62235 53.71176038825204 191.91320000000002 191.91320000000002 132.73780212162626 42.4612;147.66 20.6424;96.6023 98.0534;285.773 0 Exp 4,1(0.5);Poly 2,1(0.5) 2.5606311368642047 5.144704818725586 2.327066659927368 2.8176381587982178 0.3468864335084265 2.572352409362793 -8.034224000000009 198.15542399999998 -15.81835199999999 133.06305199999997 7.947992000000028 375.87840800000004 DOWN 0.0 1.0 0.0 GO:0014070 5 response to organic cyclic compound 433 471 38 37 23 27 19 19 49 452 2027 0.98211 0.034916 0.055651 4.03 25671;89776;25154;362282;24314;81687;291234;24426;25283;25315;24296;245920;113902;114494;24232;25612;29221;24646;170913 smad1;slc22a7;pgr;pck1;nqo1;mmp9;mki67;gstp1;gclc;ephx1;cyp1a1;cxcl10;ces1d;ccna2;c3;asns;arg1;abcb1b;abcb1a SMAD1_32578;SLC22A7_9847;PGR_32824;PCK1_9439;NQO1_33055;MMP9_32531;MKI67_9232;GSTP1_8762;GCLC_8699;EPHX1_8567;CYP1A1_8415;CXCL10_8408;CES1D_32914;CCNA2_8221;C3_8175;ASNS_8091;ARG1_33267;ABCB1B_7939;ABCB1A_7938 208.90075263157894 49.1516 11.0684 263.4187255519314 186.1165365554226 254.22902690077618 116.62258368421054 18.9587 4.18343 156.73142475423705 100.96985873631606 150.76055781720007 684.5164947368421 161.307 17.0564 843.6590665513617 638.7292210034126 840.1707927754367 21.9973;49.1516;283.618;529.244;25.6813;728.316;21.9311;14.7631;131.7;39.2381;12.8863;670.528;11.0684;14.384;234.759;191.145;760.927;20.7941;206.982 5.02186;13.5995;138.711;356.883;7.73944;443.137;6.82654;9.42992;39.9158;18.9587;9.13136;374.802;4.18343;4.89199;129.148;113.564;413.607;8.25355;118.025 80.1461;161.307;1554.21;1021.06;86.1211;2039.06;76.1794;25.7196;397.209;81.6965;19.3234;1955.3;17.0564;58.2504;694.216;510.267;2639.93;57.2115;1531.55 5 14 5 362282;24314;24426;25315;24296 PCK1_9439;NQO1_33055;GSTP1_8762;EPHX1_8567;CYP1A1_8415 124.36256 25.6813 226.57898368881877 80.428484 9.42992 154.60708817852458 246.78411999999997 81.6965 433.92901716994794 529.244;25.6813;14.7631;39.2381;12.8863 356.883;7.73944;9.42992;18.9587;9.13136 1021.06;86.1211;25.7196;81.6965;19.3234 14 25671;89776;25154;81687;291234;25283;245920;113902;114494;24232;25612;29221;24646;170913 SMAD1_32578;SLC22A7_9847;PGR_32824;MMP9_32531;MKI67_9232;GCLC_8699;CXCL10_8408;CES1D_32914;CCNA2_8221;C3_8175;ASNS_8091;ARG1_33267;ABCB1B_7939;ABCB1A_7938 239.0929642857143 161.4225 276.6783749293937 129.54904785714285 76.73989999999999 161.16463901974868 840.8494857142857 453.738 909.7043216238422 21.9973;49.1516;283.618;728.316;21.9311;131.7;670.528;11.0684;14.384;234.759;191.145;760.927;20.7941;206.982 5.02186;13.5995;138.711;443.137;6.82654;39.9158;374.802;4.18343;4.89199;129.148;113.564;413.607;8.25355;118.025 80.1461;161.307;1554.21;2039.06;76.1794;397.209;1955.3;17.0564;58.2504;694.216;510.267;2639.93;57.2115;1531.55 0 Exp 2,2(0.11);Exp 4,6(0.32);Exp 5,1(0.06);Hill,4(0.22);Linear,2(0.11);Poly 2,4(0.22) 2.215367100804863 53.97917354106903 1.513624906539917 15.48720932006836 3.246080118747335 1.8874764442443848 90.45324816559987 327.348257097558 46.14754021628937 187.0976271521317 305.161113513552 1063.8718759601322 DOWN 0.2631578947368421 0.7368421052631579 0.0 GO:0009062 6 fatty acid catabolic process 37 42 4 4 4 4 4 4 64 38 2441 0.99538 0.024263 0.024263 9.52 25682;362282;113902;252898 ppard;pck1;ces1d;acox2 PPARD_9536;PCK1_9439;CES1D_32914;ACOX2_32902 344.4432 311.6757 11.0684 349.80334201441434 332.8710073803731 359.3724573998197 207.8431575 197.3261 4.18343 218.40530605194073 192.52776372871045 220.94864212217243 868.59785 584.7725 17.0564 1045.7909962651029 890.284484347121 1126.2213304684935 1.5 311.6757 94.1074;529.244;11.0684;743.353 37.7692;356.883;4.18343;432.537 148.485;1021.06;17.0564;2287.79 1 3 1 362282 PCK1_9439 529.244 529.244 356.883 356.883 1021.06 1021.06 529.244 356.883 1021.06 3 25682;113902;252898 PPARD_9536;CES1D_32914;ACOX2_32902 282.8429333333333 94.1074 400.9688391960817 158.16321 37.7692 238.20733293886292 817.7771333333334 148.485 1274.7634056359843 94.1074;11.0684;743.353 37.7692;4.18343;432.537 148.485;17.0564;2287.79 0 Exp 2,1(0.25);Exp 5,2(0.5);Linear,1(0.25) 1.6705042950152915 6.709246754646301 1.5319663286209106 1.9388991594314575 0.17928598256638095 1.6191906332969666 1.6359248258739854 687.250475174126 -6.194042430901959 421.8803574309019 -156.27732633980088 1893.473026339801 DOWN 0.25 0.75 0.0 GO:0045069 7 regulation of viral genome replication 22 24 4 4 2 3 2 2 66 22 2457 0.97533 0.13319 0.13319 8.33 360243;304545 top2a;oasl TOP2A_10059;OASL_9389 81.50045 81.50045 76.6126 6.912463760845235 84.55178171180933 5.400083778425136 27.56825 27.56825 26.6888 1.243730117429154 27.01923690140845 0.9716140386748151 261.331 261.331 260.389 1.3321891757624038 261.9190611050921 1.0407191135771878 0.5 81.50045 86.3883;76.6126 26.6888;28.4477 262.273;260.389 0 2 0 2 360243;304545 TOP2A_10059;OASL_9389 81.50045 81.50045 6.912463760845235 27.56825 27.56825 1.243730117429154 261.331 261.331 1.3321891757624038 86.3883;76.6126 26.6888;28.4477 262.273;260.389 0 Exp 4,2(1) 1.926242801385089 3.8530784845352173 1.8927439451217651 1.9603345394134521 0.04779376756808064 1.9265392422676086 71.920264 91.080636 25.844528 29.291971999999998 259.48468 263.17732 DOWN 0.0 1.0 0.0 GO:0051707 4 response to other organism 231 253 22 22 14 16 11 11 57 242 2237 0.96731 0.068599 0.096554 4.35 688621;295703;362282;304545;362376;24296;245920;24854;29397;24232;29221 tslp;serping1;pck1;oasl;herc6;cyp1a1;cxcl10;clu;ccl11;c3;arg1 TSLP_32811;SERPING1_32597;PCK1_9439;OASL_9389;HERC6_8794;CYP1A1_8415;CXCL10_8408;CLU_32773;CCL11_33230;C3_8175;ARG1_33267 420.34937272727274 344.675 12.8863 373.66218199149637 445.2149987825639 390.7862243351039 267.92552363636366 244.2 9.13136 261.9842091458517 284.61453198761933 269.8051718749791 973.5871727272727 694.216 19.3234 918.2134089078029 1026.7398896672685 992.1929981224073 344.675;32.3997;529.244;76.6126;39.6865;12.8863;670.528;935.649;986.476;234.759;760.927 244.2;13.7308;356.883;28.4477;15.7729;9.13136;374.802;808.484;552.974;129.148;413.607 560.435;99.4885;1021.06;260.389;157.407;19.3234;1955.3;1071.05;2230.86;694.216;2639.93 3 8 3 362282;24296;29397 PCK1_9439;CYP1A1_8415;CCL11_33230 509.5354333333333 529.244 487.0939813696771 306.32945333333333 356.883 275.4232199379285 1090.4144666666668 1021.06 1107.3983315952094 529.244;12.8863;986.476 356.883;9.13136;552.974 1021.06;19.3234;2230.86 8 688621;295703;304545;362376;245920;24854;24232;29221 TSLP_32811;SERPING1_32597;OASL_9389;HERC6_8794;CXCL10_8408;CLU_32773;C3_8175;ARG1_33267 386.9046 289.717 356.35100800270754 253.52405 186.67399999999998 274.7875941429567 929.7769375 627.3254999999999 919.7978015247401 344.675;32.3997;76.6126;39.6865;670.528;935.649;234.759;760.927 244.2;13.7308;28.4477;15.7729;374.802;808.484;129.148;413.607 560.435;99.4885;260.389;157.407;1955.3;1071.05;694.216;2639.93 0 Exp 2,3(0.28);Exp 4,4(0.37);Linear,1(0.1);Poly 2,2(0.19);Power,1(0.1) 2.085874011446717 32.623475790023804 1.513624906539917 15.48720932006836 4.155681771023994 1.7183171510696411 199.52913438344328 641.1696110711023 113.1027497672564 422.74829750547093 430.95772405019056 1516.2166214043548 DOWN 0.2727272727272727 0.7272727272727273 0.0 GO:0045454 4 cell redox homeostasis 21 21 2 2 2 2 2 2 66 19 2460 0.98284 0.10656 0.10656 9.52 24314;25283 nqo1;gclc NQO1_33055;GCLC_8699 78.69064999999999 78.69064999999999 25.6813 74.96654170258222 83.35959029065 74.67519245351625 23.82762 23.82762 7.73944 22.752122349899576 25.24462948616102 22.66369871969399 241.66505 241.66505 86.1211 219.97236363508253 255.36499944518002 219.11746514964068 0.5 78.69064999999999 25.6813;131.7 7.73944;39.9158 86.1211;397.209 1 1 1 24314 NQO1_33055 25.6813 25.6813 7.73944 7.73944 86.1211 86.1211 25.6813 7.73944 86.1211 1 25283 GCLC_8699 131.7 131.7 39.9158 39.9158 397.209 397.209 131.7 39.9158 397.209 0 Hill,2(1) 2.0713665688403 4.14746630191803 1.9746891260147095 2.1727771759033203 0.14006940334825585 2.073733150959015 -25.207675999999978 182.588976 -7.705212799999998 55.36045279999999 -63.20109199999996 546.5311919999999 CONFLICT 0.5 0.5 0.0 GO:0050777 6 negative regulation of immune response 45 49 6 6 5 5 4 4 64 45 2434 0.99102 0.039983 0.039983 8.16 295703;84032;29221;81639 serping1;col3a1;arg1;alox15 SERPING1_32597;COL3A1_8354;ARG1_33267;ALOX15_8036 443.187175 486.765 32.3997 377.5409761077452 530.6677926511802 365.73560589421436 242.04895 266.7085 13.7308 206.99787675016546 289.6781745282432 200.57622660301476 1728.044625 2075.31 99.4885 1211.524717531135 1962.347297004422 1169.4913232609026 1.5 486.765 32.3997;212.603;760.927;766.819 13.7308;119.81;413.607;421.048 99.4885;1510.69;2639.93;2662.07 0 4 0 4 295703;84032;29221;81639 SERPING1_32597;COL3A1_8354;ARG1_33267;ALOX15_8036 443.187175 486.765 377.5409761077452 242.04895 266.7085 206.99787675016546 1728.044625 2075.31 1211.524717531135 32.3997;212.603;760.927;766.819 13.7308;119.81;413.607;421.048 99.4885;1510.69;2639.93;2662.07 0 Exp 2,2(0.5);Exp 4,1(0.25);Poly 2,1(0.25) 1.5844041531185542 6.34707248210907 1.5021449327468872 1.7183171510696411 0.1008356941648465 1.5633051991462708 73.19701841440957 813.1773315855903 39.19103078483792 444.90686921516215 540.7504018194877 2915.3388481805123 DOWN 0.0 1.0 0.0 GO:0044249 4 cellular biosynthetic process 372 415 20 20 16 15 13 13 55 402 2077 0.79347 0.30858 0.50638 3.13 25682;299112;288583;362282;300795;24426;156275;25283;312495;24296;25612;29221;81639 ppard;pole2;plod3;pck1;pclaf;gstp1;ggt7;gclc;cyp26b1;cyp1a1;asns;arg1;alox15 PPARD_9536;POLE2_9520;PLOD3_9507;PCK1_9439;NS5ATP9_9367;GSTP1_8762;GGT7_33026;GCLC_8699;CYP26B1_8418;CYP1A1_8415;ASNS_8091;ARG1_33267;ALOX15_8036 292.6333077131998 131.7 2.71598E-7 325.80231256542055 237.08459054901104 303.1934556761944 170.29934463627677 39.9158 2.71598E-7 209.95544031007432 128.4876633025024 181.8030732505166 736.2598538670461 397.209 2.71599E-7 925.1409464433839 690.2760617607495 975.1292724329606 94.1074;2.71598E-7;882.629;529.244;292.216;14.7631;109.609;131.7;18.1872;12.8863;191.145;760.927;766.819 37.7692;2.71598E-7;625.677;356.883;147.515;9.42992;29.3336;39.9158;10.0176;9.13136;113.564;413.607;421.048 148.485;2.71599E-7;1106.02;1021.06;658.494;25.7196;346.073;397.209;36.7271;19.3234;510.267;2639.93;2662.07 4 9 4 362282;24426;312495;24296 PCK1_9439;GSTP1_8762;CYP26B1_8418;CYP1A1_8415 143.77015 16.47515 256.9919372957383 96.36546999999999 9.723759999999999 173.6787435584566 275.707525 31.22335 496.953632216537 529.244;14.7631;18.1872;12.8863 356.883;9.42992;10.0176;9.13136 1021.06;25.7196;36.7271;19.3234 9 25682;299112;288583;300795;156275;25283;25612;29221;81639 PPARD_9536;POLE2_9520;PLOD3_9507;NS5ATP9_9367;GGT7_33026;GCLC_8699;ASNS_8091;ARG1_33267;ALOX15_8036 358.79471114128864 191.145 344.16461438189594 203.15884447462201 113.564 225.5271417301771 940.9497778079555 510.267 1018.8366549985105 94.1074;2.71598E-7;882.629;292.216;109.609;131.7;191.145;760.927;766.819 37.7692;2.71598E-7;625.677;147.515;29.3336;39.9158;113.564;413.607;421.048 148.485;2.71599E-7;1106.02;658.494;346.073;397.209;510.267;2639.93;2662.07 0 Exp 2,3(0.24);Exp 4,4(0.31);Exp 5,1(0.08);Hill,2(0.16);Linear,1(0.08);Poly 2,2(0.16) 2.187991581848796 38.41422915458679 1.5021449327468872 15.48720932006836 3.801216747625501 1.805381178855896 115.52515313674101 469.74146228965867 56.16626717649521 284.4324220960583 233.3475066294697 1239.1722011046224 DOWN 0.3076923076923077 0.6923076923076923 0.0 GO:0006869 6 lipid transport 73 76 6 6 5 5 4 4 64 72 2407 0.9499 0.14292 0.14292 5.26 25682;113902;24646;170913 ppard;ces1d;abcb1b;abcb1a PPARD_9536;CES1D_32914;ABCB1B_7939;ABCB1A_7938 83.237975 57.45075 11.0684 90.44042828242891 88.37513257686676 94.28117553824812 42.057795 23.011375 4.18343 52.809730122264725 45.74881908034406 55.589096279077644 438.575725 102.84825000000001 17.0564 730.7216998741968 506.7997540995608 768.1757703798128 2.5 150.5447 94.1074;11.0684;20.7941;206.982 37.7692;4.18343;8.25355;118.025 148.485;17.0564;57.2115;1531.55 0 4 0 4 25682;113902;24646;170913 PPARD_9536;CES1D_32914;ABCB1B_7939;ABCB1A_7938 83.237975 57.45075 90.44042828242891 42.057795 23.011375 52.809730122264725 438.575725 102.84825000000001 730.7216998741968 94.1074;11.0684;20.7941;206.982 37.7692;4.18343;8.25355;118.025 148.485;17.0564;57.2115;1531.55 0 Exp 5,2(0.5);Hill,1(0.25);Poly 2,1(0.25) 2.464020323700543 11.644349575042725 1.6269687414169312 6.191005229949951 2.1908712927651606 1.9131878018379211 -5.393644716780315 171.86959471678034 -9.695740519819424 93.81133051981942 -277.5315408767129 1154.682990876713 DOWN 0.0 1.0 0.0 GO:2001257 7 regulation of cation channel activity 35 35 4 4 2 3 2 2 66 33 2446 0.93513 0.23954 0.23954 5.71 81687;686019 mmp9;casq1 MMP9_32531;CASQ1_32992 437.988 437.988 147.66 410.58579513665603 392.3094370537392 405.4721111769946 269.86965 269.86965 96.6023 245.03703628644593 242.60874663033945 241.98519675175393 1162.4165 1162.4165 285.773 1239.7611270662183 1024.4903774896654 1224.3203917451624 0.5 437.988 728.316;147.66 443.137;96.6023 2039.06;285.773 0 2 0 2 81687;686019 MMP9_32531;CASQ1_32992 437.988 437.988 410.58579513665603 269.86965 269.86965 245.03703628644593 1162.4165 1162.4165 1239.7611270662183 728.316;147.66 443.137;96.6023 2039.06;285.773 0 Linear,1(0.5);Poly 2,1(0.5) 2.184861584229304 4.378413200378418 2.05134654045105 2.327066659927368 0.19496356619126978 2.189206600189209 -131.05487999999997 1007.03088 -69.73435599999993 609.4736559999999 -555.8047599999998 2880.6377599999996 DOWN 0.0 1.0 0.0 GO:0001101 4 response to acid chemical 195 202 19 18 14 15 12 12 56 190 2289 0.99791 0.0061093 0.009464 5.94 116669;684352;362282;24314;81687;24426;25283;312495;84032;25612;29221;170913 vwf;twf2;pck1;nqo1;mmp9;gstp1;gclc;cyp26b1;col3a1;asns;arg1;abcb1a VWF_32396;TWF2_10109;PCK1_9439;NQO1_33055;MMP9_32531;GSTP1_8762;GCLC_8699;CYP26B1_8418;COL3A1_8354;ASNS_8091;ARG1_33267;ABCB1A_7938 248.13533333333336 164.772 14.7631 271.9244822223403 222.14464264807108 272.15429948586495 143.915125 102.15015 4.11644 164.46648020490545 123.57002102175797 162.4260170219202 849.2980666666667 453.738 25.7196 887.6745824711137 783.0047676622869 901.0147580045964 9.5 628.78 19.6764;138.399;529.244;25.6813;728.316;14.7631;131.7;18.1872;212.603;191.145;760.927;206.982 4.11644;90.7363;356.883;7.73944;443.137;9.42992;39.9158;10.0176;119.81;113.564;413.607;118.025 94.078;299.165;1021.06;86.1211;2039.06;25.7196;397.209;36.7271;1510.69;510.267;2639.93;1531.55 4 8 4 362282;24314;24426;312495 PCK1_9439;NQO1_33055;GSTP1_8762;CYP26B1_8418 146.96890000000002 21.93425 254.89084840528636 96.01749 9.723759999999999 173.91302115126362 292.40695 61.424099999999996 486.4783131619092 529.244;25.6813;14.7631;18.1872 356.883;7.73944;9.42992;10.0176 1021.06;86.1211;25.7196;36.7271 8 116669;684352;81687;25283;84032;25612;29221;170913 VWF_32396;TWF2_10109;MMP9_32531;GCLC_8699;COL3A1_8354;ASNS_8091;ARG1_33267;ABCB1A_7938 298.71855 199.0635 282.09832306893594 167.8639425 115.7945 166.0632998121315 1127.743625 1010.4785 933.2644752659401 19.6764;138.399;728.316;131.7;212.603;191.145;760.927;206.982 4.11644;90.7363;443.137;39.9158;119.81;113.564;413.607;118.025 94.078;299.165;2039.06;397.209;1510.69;510.267;2639.93;1531.55 0 Exp 2,1(0.09);Exp 4,2(0.17);Hill,3(0.25);Linear,2(0.17);Poly 2,4(0.34) 1.962615433049306 24.134165406227112 1.513624906539917 3.5281898975372314 0.5234094240376284 1.9310827851295471 94.2795737832219 401.99109288344476 50.859453713407035 236.97079628659299 347.0488907070303 1351.5472426263032 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0044260 4 cellular macromolecule metabolic process 676 733 45 45 32 29 23 23 45 710 1769 0.85665 0.21123 0.34473 3.14 315852;360243;24832;25671;291463;25682;299112;288583;363131;362282;300795;313108;291234;316273;293502;362376;156275;81919;84032;297594;114494;29397;29657 ttk;top2a;thy1;smad1;ppic;ppard;pole2;plod3;pik3r4;pck1;pclaf;mms22l;mki67;mcm3;kif22;herc6;ggt7;fut1;col3a1;cdca3;ccna2;ccl11;arntl TTK_32727;TOP2A_10059;THY1_33010;SMAD1_32578;PPIC_9541;PPARD_9536;POLE2_9520;PLOD3_9507;PIK3R4_9484;PCK1_9439;NS5ATP9_9367;MMS22L_33129;MKI67_9232;MCM3_9207;KIF22_8963;HERC6_8794;GGT7_33026;FUT1_8668;COL3A1_8354;CDCA3_8260;CCNA2_8221;CCL11_33230;ARNTL_8086 272.8084739248523 109.609 5.72311E-12 333.802424483524 200.11277326389893 291.3186290559406 166.00381435963496 37.7692 5.72311E-12 228.58781382431008 112.2622778194854 187.53669215889045 627.803704359635 262.273 5.72313E-12 693.6864789973448 503.3037684637914 663.0469435618631 737.351;86.3883;5.72311E-12;21.9973;628.678;94.1074;2.71598E-7;882.629;955.628;529.244;292.216;126.653;21.9311;197.273;17.3097;39.6865;109.609;240.861;212.603;56.6562;14.384;986.476;22.9134 446.625;26.6888;5.72311E-12;5.02186;389.239;37.7692;2.71598E-7;625.677;735.228;356.883;147.515;85.587;6.82654;116.413;3.12114;15.7729;29.3336;78.9726;119.81;22.3266;4.89199;552.974;11.4115 2108.09;262.273;5.72313E-12;80.1461;1509.86;148.485;2.71599E-7;1106.02;1288.97;1021.06;658.494;240.486;76.1794;496.915;90.6321;157.407;346.073;847.87;1510.69;150.565;58.2504;2230.86;50.1592 2 21 2 362282;29397 PCK1_9439;CCL11_33230 757.86 757.86 323.3118477754875 454.9285 454.9285 138.65727582965147 1625.96 1625.96 855.4577838794855 529.244;986.476 356.883;552.974 1021.06;2230.86 21 315852;360243;24832;25671;291463;25682;299112;288583;363131;300795;313108;291234;316273;293502;362376;156275;81919;84032;297594;114494;29657 TTK_32727;TOP2A_10059;THY1_33010;SMAD1_32578;PPIC_9541;PPARD_9536;POLE2_9520;PLOD3_9507;PIK3R4_9484;NS5ATP9_9367;MMS22L_33129;MKI67_9232;MCM3_9207;KIF22_8963;HERC6_8794;GGT7_33026;FUT1_8668;COL3A1_8354;CDCA3_8260;CCNA2_8221;ARNTL_8086 226.61309048912395 94.1074 302.6082029398592 138.48717763198113 29.3336 217.65469102679603 532.7412000129336 240.486 619.3628181334084 737.351;86.3883;5.72311E-12;21.9973;628.678;94.1074;2.71598E-7;882.629;955.628;292.216;126.653;21.9311;197.273;17.3097;39.6865;109.609;240.861;212.603;56.6562;14.384;22.9134 446.625;26.6888;5.72311E-12;5.02186;389.239;37.7692;2.71598E-7;625.677;735.228;147.515;85.587;6.82654;116.413;3.12114;15.7729;29.3336;78.9726;119.81;22.3266;4.89199;11.4115 2108.09;262.273;5.72313E-12;80.1461;1509.86;148.485;2.71599E-7;1106.02;1288.97;658.494;240.486;76.1794;496.915;90.6321;157.407;346.073;847.87;1510.69;150.565;58.2504;50.1592 0 Exp 2,3(0.14);Exp 4,8(0.35);Exp 5,1(0.05);Hill,3(0.14);Linear,2(0.09);Poly 2,5(0.22);Power,1(0.05) 1.8415663980338497 43.20580291748047 1.5018656253814697 3.442979335784912 0.4338073015637991 1.7774014472961426 136.38734469890687 409.22960315079774 72.58266040171402 259.4249683175558 344.30219013303963 911.3052185862305 DOWN 0.08695652173913043 0.9130434782608695 0.0 GO:0015031 5 protein transport 172 184 8 8 5 6 4 4 64 180 2299 0.44775 0.73657 0.81536 2.17 363131;24367;24854;29657 pik3r4;fgg;clu;arntl PIK3R4_9484;FGG_8639;CLU_32773;ARNTL_8086 489.16290000000004 489.0551 22.9134 527.2161264745101 414.83975058823523 513.67879318479 393.94147499999997 377.93519999999995 11.4115 437.417945962176 337.735119644154 436.59421568163816 627.0581500000001 584.5517 50.1592 644.9585216819527 527.4340948293391 602.2997539120709 955.628;42.4612;935.649;22.9134 735.228;20.6424;808.484;11.4115 1288.97;98.0534;1071.05;50.1592 0 4 0 4 363131;24367;24854;29657 PIK3R4_9484;FGG_8639;CLU_32773;ARNTL_8086 489.16290000000004 489.0551 527.2161264745101 393.94147499999997 377.93519999999995 437.417945962176 627.0581500000001 584.5517 644.9585216819527 955.628;42.4612;935.649;22.9134 735.228;20.6424;808.484;11.4115 1288.97;98.0534;1071.05;50.1592 0 Exp 4,2(0.5);Poly 2,2(0.5) 2.181651787961048 9.317342162132263 1.5018656253814697 3.442979335784912 0.9597156274488924 2.1862486004829407 -27.508903945019995 1005.83470394502 -34.728112042932594 822.6110620429325 -5.001201248313691 1259.1175012483138 DOWN 0.0 1.0 0.0 GO:0031589 4 cell-substrate adhesion 43 44 7 7 6 5 5 5 63 39 2440 0.99908 0.0056656 0.0056656 11.36 116669;25682;24367;309186;84032 vwf;ppard;fgg;fermt3;col3a1 VWF_32396;PPARD_9536;FGG_8639;FERMT3_32542;COL3A1_8354 181.5922 94.1074 19.6764 213.31346876777383 121.58925906944337 187.8892800017055 103.31720800000001 37.7692 4.11644 136.54074527782655 66.65787613068049 119.24825395286946 607.8332800000001 148.485 94.078 686.7317723978497 381.52395560114576 578.059708768178 1.5 68.2843 3.5 375.85800000000006 19.6764;94.1074;42.4612;539.113;212.603 4.11644;37.7692;20.6424;334.248;119.81 94.078;148.485;98.0534;1187.86;1510.69 0 5 0 5 116669;25682;24367;309186;84032 VWF_32396;PPARD_9536;FGG_8639;FERMT3_32542;COL3A1_8354 181.5922 94.1074 213.31346876777383 103.31720800000001 37.7692 136.54074527782655 607.8332800000001 148.485 686.7317723978497 19.6764;94.1074;42.4612;539.113;212.603 4.11644;37.7692;20.6424;334.248;119.81 94.078;148.485;98.0534;1187.86;1510.69 0 Exp 2,1(0.2);Exp 4,1(0.2);Exp 5,1(0.2);Hill,1(0.2);Poly 2,1(0.2) 1.9845393722235891 10.131185412406921 1.6129854917526245 2.8176381587982178 0.48362967681658936 1.9388991594314575 -5.3852993389600385 368.56969933896005 -16.366032150763786 223.00044815076376 5.886341246921916 1209.7802187530783 DOWN 0.0 1.0 0.0 GO:1904036 9 negative regulation of epithelial cell apoptotic process 26 27 3 3 2 3 2 2 66 25 2454 0.96631 0.16114 0.16114 7.41 25154;24367 pgr;fgg PGR_32824;FGG_8639 163.0396 163.0396 42.4612 170.52360860924802 104.76591041869521 149.28715717798187 79.67670000000001 79.67670000000001 20.6424 83.48710770520199 51.14632911392405 73.0898968885981 826.1317 826.1317 98.0534 1029.658206329547 474.262635183382 901.4279473767925 0.5 163.0396 283.618;42.4612 138.711;20.6424 1554.21;98.0534 0 2 0 2 25154;24367 PGR_32824;FGG_8639 163.0396 163.0396 170.52360860924802 79.67670000000001 79.67670000000001 83.48710770520199 826.1317 826.1317 1029.658206329547 283.618;42.4612 138.711;20.6424 1554.21;98.0534 0 Exp 4,1(0.5);Poly 2,1(0.5) 2.083462075854302 4.358224272727966 1.5405861139297485 2.8176381587982178 0.9030121608546418 2.179112136363983 -73.29406399999999 399.373264 -36.030528000000004 195.38392800000003 -600.9017679999998 2253.165168 DOWN 0.0 1.0 0.0 GO:1904062 7 regulation of cation transmembrane transport 77 80 8 7 4 6 4 4 64 76 2403 0.93988 0.16314 0.16314 5.0 24832;81687;245920;686019 thy1;mmp9;cxcl10;casq1 THY1_33010;MMP9_32531;CXCL10_8408;CASQ1_32992 386.62600000000145 409.094 5.72311E-12 366.9408738638946 347.54658664868606 349.34445395745075 228.63532500000144 235.70215000000002 5.72311E-12 213.7619368884187 212.20065931509578 207.70629514892985 1070.0332500000013 1120.5365 5.72313E-12 1077.4577109577183 921.565329303536 1030.0041859824578 3.0 728.316 5.72311E-12;728.316;670.528;147.66 5.72311E-12;443.137;374.802;96.6023 5.72313E-12;2039.06;1955.3;285.773 0 4 0 4 24832;81687;245920;686019 THY1_33010;MMP9_32531;CXCL10_8408;CASQ1_32992 386.62600000000145 409.094 366.9408738638946 228.63532500000144 235.70215000000002 213.7619368884187 1070.0332500000013 1120.5365 1077.4577109577183 5.72311E-12;728.316;670.528;147.66 5.72311E-12;443.137;374.802;96.6023 5.72313E-12;2039.06;1955.3;285.773 0 Exp 2,1(0.25);Hill,1(0.25);Linear,1(0.25);Poly 2,1(0.25) 2.015083600553898 8.09542202949524 1.8538048267364502 2.327066659927368 0.22167461136719985 1.9572752714157104 27.023943613384745 746.2280563866182 19.148626849351132 438.1220231506518 14.124693261437415 2125.941806738565 DOWN 0.0 1.0 0.0 GO:0045091 8 regulation of single stranded viral RNA replication via double stranded DNA intermediate 1 1 1 1 1 1 1 1 67 0 2479 1.0 0.026698 0.026698 100.0 360243 top2a TOP2A_10059 86.3883 86.3883 86.3883 86.3883 26.6888 26.6888 26.6888 26.6888 262.273 262.273 262.273 262.273 0.0 86.3883 0.0 86.3883 86.3883 26.6888 262.273 0 1 0 1 360243 TOP2A_10059 86.3883 86.3883 26.6888 26.6888 262.273 262.273 86.3883 26.6888 262.273 0 Exp 4,1(1) 1.9603345394134521 1.9603345394134521 1.9603345394134521 1.9603345394134521 0.0 1.9603345394134521 86.3883 86.3883 26.6888 26.6888 262.273 262.273 DOWN 0.0 1.0 0.0 GO:0045870 8 positive regulation of single stranded viral RNA replication via double stranded DNA intermediate 1 1 1 1 1 1 1 1 67 0 2479 1.0 0.026698 0.026698 100.0 360243 top2a TOP2A_10059 86.3883 86.3883 86.3883 86.3883 26.6888 26.6888 26.6888 26.6888 262.273 262.273 262.273 262.273 0.0 86.3883 0.0 86.3883 86.3883 26.6888 262.273 0 1 0 1 360243 TOP2A_10059 86.3883 86.3883 26.6888 26.6888 262.273 262.273 86.3883 26.6888 262.273 0 Exp 4,1(1) 1.9603345394134521 1.9603345394134521 1.9603345394134521 1.9603345394134521 0.0 1.9603345394134521 86.3883 86.3883 26.6888 26.6888 262.273 262.273 DOWN 0.0 1.0 0.0 GO:0009894 5 regulation of catabolic process 212 227 9 9 7 6 4 4 64 223 2256 0.26084 0.86968 0.51687 1.76 25283;24854;246142;29657 gclc;clu;bmf;arntl GCLC_8699;CLU_32773;BMF_8152;ARNTL_8086 302.41585 125.5505 22.9134 424.9486943842633 270.9965135215169 368.2109715173291 235.409975 60.87219999999999 11.4115 383.14243049543495 195.8773138319721 339.27509926987057 434.62579999999997 308.647 50.1592 447.3172254854788 441.9063571571859 365.5473016942932 131.7;935.649;119.401;22.9134 39.9158;808.484;81.8286;11.4115 397.209;1071.05;220.085;50.1592 0 4 0 4 25283;24854;246142;29657 GCLC_8699;CLU_32773;BMF_8152;ARNTL_8086 302.41585 125.5505 424.9486943842633 235.409975 60.87219999999999 383.14243049543495 434.62579999999997 308.647 447.3172254854788 131.7;935.649;119.401;22.9134 39.9158;808.484;81.8286;11.4115 397.209;1071.05;220.085;50.1592 0 Exp 4,1(0.25);Hill,1(0.25);Poly 2,2(0.5) 2.0290397364126367 8.575913310050964 1.5548590421676636 3.442979335784912 0.8860707759215182 1.7890374660491943 -114.033870496578 718.8655704965781 -140.06960688552624 610.8895568855263 -3.745080975769099 872.9966809757691 DOWN 0.0 1.0 0.0 GO:0050801 6 ion homeostasis 172 181 15 14 6 9 4 4 64 177 2302 0.46288 0.72442 1.0 2.21 24832;25283;245920;686019 thy1;gclc;cxcl10;casq1 THY1_33010;GCLC_8699;CXCL10_8408;CASQ1_32992 237.47200000000143 139.68 5.72311E-12 296.18933204286594 152.34820861277882 165.1341822588785 127.83002500000143 68.25905 5.72311E-12 169.35146244120645 78.06040098394014 97.42598470908595 659.5705000000014 341.491 5.72313E-12 879.8686093822934 390.23558100953136 490.7387692605474 5.72311E-12;131.7;670.528;147.66 5.72311E-12;39.9158;374.802;96.6023 5.72313E-12;397.209;1955.3;285.773 0 4 0 4 24832;25283;245920;686019 THY1_33010;GCLC_8699;CXCL10_8408;CASQ1_32992 237.47200000000143 139.68 296.18933204286594 127.83002500000143 68.25905 169.35146244120645 659.5705000000014 341.491 879.8686093822934 5.72311E-12;131.7;670.528;147.66 5.72311E-12;39.9158;374.802;96.6023 5.72313E-12;397.209;1955.3;285.773 0 Exp 2,1(0.25);Hill,2(0.5);Poly 2,1(0.25) 1.9959883124181284 8.018764615058899 1.8538048267364502 2.327066659927368 0.22181928555596456 1.9189465641975403 -52.793545402007226 527.73754540201 -38.13440819238089 293.7944581923838 -202.70073719464608 1521.8417371946489 DOWN 0.0 1.0 0.0 GO:0071300 6 cellular response to retinoic acid 19 22 4 4 3 4 3 3 65 19 2460 0.99763 0.019495 0.019495 13.64 684352;362282;312495 twf2;pck1;cyp26b1 TWF2_10109;PCK1_9439;CYP26B1_8418 228.61006666666665 138.399 18.1872 267.2045856986989 110.6922348197696 194.00056401222105 152.5456333333333 90.7363 10.0176 181.50536271588044 72.5499650130063 131.6191348222267 452.31736666666666 299.165 36.7271 509.7249749299158 223.8611825343738 375.96689106000207 0.5 78.2931 1.5 333.8215 138.399;529.244;18.1872 90.7363;356.883;10.0176 299.165;1021.06;36.7271 2 1 2 362282;312495 PCK1_9439;CYP26B1_8418 273.7156 273.7156 361.3717288514972 183.4503 183.4503 245.27087649898422 528.89355 528.89355 696.0284685350197 529.244;18.1872 356.883;10.0176 1021.06;36.7271 1 684352 TWF2_10109 138.399 138.399 90.7363 90.7363 299.165 299.165 138.399 90.7363 299.165 0 Exp 4,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 1.821663491974311 5.496406078338623 1.611412525177002 2.090334892272949 0.24165064789334958 1.7946586608886719 -73.760386717752 530.9805200510854 -52.84701991248025 357.93828657914696 -124.49074225071922 1029.1254755840525 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0007179 8 transforming growth factor beta receptor signaling pathway 27 29 4 4 2 3 2 2 66 27 2452 0.95947 0.18033 0.18033 6.9 25671;84032 smad1;col3a1 SMAD1_32578;COL3A1_8354 117.30015 117.30015 21.9973 134.77858300280872 153.2886388111888 124.79953438382246 62.41593 62.41593 5.02186 81.16747219379077 84.08921517482517 75.15780705815736 795.41805 795.41805 80.1461 1011.5472924750505 1065.5207444055945 936.6520132169046 0.5 117.30015 21.9973;212.603 5.02186;119.81 80.1461;1510.69 0 2 0 2 25671;84032 SMAD1_32578;COL3A1_8354 117.30015 117.30015 134.77858300280872 62.41593 62.41593 81.16747219379077 795.41805 795.41805 1011.5472924750505 21.9973;212.603 5.02186;119.81 80.1461;1510.69 0 Exp 4,1(0.5);Poly 2,1(0.5) 1.6526136931518136 3.3062009811401367 1.6129854917526245 1.6932154893875122 0.05673117538220976 1.6531004905700684 -69.49343599999997 304.093736 -50.076447199999976 174.90830719999997 -606.5149719999998 2197.351072 DOWN 0.0 1.0 0.0 GO:0071310 5 cellular response to organic substance 516 551 46 45 29 33 25 25 43 526 1953 0.99881 0.0027802 0.0040618 4.54 116669;684352;25671;25682;288583;25154;362282;81687;24426;25283;24367;25315;312495;24296;245920;84032;24854;113902;114494;29397;25612;29221;81639;24646;170913 vwf;twf2;smad1;ppard;plod3;pgr;pck1;mmp9;gstp1;gclc;fgg;ephx1;cyp26b1;cyp1a1;cxcl10;col3a1;clu;ces1d;ccna2;ccl11;asns;arg1;alox15;abcb1b;abcb1a VWF_32396;TWF2_10109;SMAD1_32578;PPARD_9536;PLOD3_9507;PGR_32824;PCK1_9439;MMP9_32531;GSTP1_8762;GCLC_8699;FGG_8639;EPHX1_8567;CYP26B1_8418;CYP1A1_8415;CXCL10_8408;COL3A1_8354;CLU_32773;CES1D_32914;CCNA2_8221;CCL11_33230;ASNS_8091;ARG1_33267;ALOX15_8036;ABCB1B_7939;ABCB1A_7938 309.38393999999994 138.399 11.0684 348.6810012866035 270.9676762666667 338.0966132396276 189.99162200000004 90.7363 4.11644 235.75474025594238 161.2189251547186 222.58499793022207 849.8075359999999 397.209 17.0564 912.5562761517037 788.8473590025973 932.5237176097722 19.6764;138.399;21.9973;94.1074;882.629;283.618;529.244;728.316;14.7631;131.7;42.4612;39.2381;18.1872;12.8863;670.528;212.603;935.649;11.0684;14.384;986.476;191.145;760.927;766.819;20.7941;206.982 4.11644;90.7363;5.02186;37.7692;625.677;138.711;356.883;443.137;9.42992;39.9158;20.6424;18.9587;10.0176;9.13136;374.802;119.81;808.484;4.18343;4.89199;552.974;113.564;413.607;421.048;8.25355;118.025 94.078;299.165;80.1461;148.485;1106.02;1554.21;1021.06;2039.06;25.7196;397.209;98.0534;81.6965;36.7271;19.3234;1955.3;1510.69;1071.05;17.0564;58.2504;2230.86;510.267;2639.93;2662.07;57.2115;1531.55 6 19 6 362282;24426;25315;312495;24296;29397 PCK1_9439;GSTP1_8762;EPHX1_8567;CYP26B1_8418;CYP1A1_8415;CCL11_33230 266.79911666666663 28.712650000000004 407.03756749766194 159.56576333333334 14.488150000000001 237.06978429914258 569.2311 59.2118 903.7935252650486 529.244;14.7631;39.2381;18.1872;12.8863;986.476 356.883;9.42992;18.9587;10.0176;9.13136;552.974 1021.06;25.7196;81.6965;36.7271;19.3234;2230.86 19 116669;684352;25671;25682;288583;25154;81687;25283;24367;245920;84032;24854;113902;114494;25612;29221;81639;24646;170913 VWF_32396;TWF2_10109;SMAD1_32578;PPARD_9536;PLOD3_9507;PGR_32824;MMP9_32531;GCLC_8699;FGG_8639;CXCL10_8408;COL3A1_8354;CLU_32773;CES1D_32914;CCNA2_8221;ASNS_8091;ARG1_33267;ALOX15_8036;ABCB1B_7939;ABCB1A_7938 322.83177894736843 191.145 339.5395430154631 199.59978789473683 113.564 241.0173242618713 938.4106210526317 510.267 921.3668241721346 19.6764;138.399;21.9973;94.1074;882.629;283.618;728.316;131.7;42.4612;670.528;212.603;935.649;11.0684;14.384;191.145;760.927;766.819;20.7941;206.982 4.11644;90.7363;5.02186;37.7692;625.677;138.711;443.137;39.9158;20.6424;374.802;119.81;808.484;4.18343;4.89199;113.564;413.607;421.048;8.25355;118.025 94.078;299.165;80.1461;148.485;1106.02;1554.21;2039.06;397.209;98.0534;1955.3;1510.69;1071.05;17.0564;58.2504;510.267;2639.93;2662.07;57.2115;1531.55 0 Exp 2,3(0.12);Exp 4,7(0.28);Exp 5,2(0.08);Hill,3(0.12);Linear,2(0.08);Poly 2,7(0.28);Power,1(0.04) 2.131023307053613 65.5404942035675 1.5021449327468872 15.48720932006836 2.8475194444999596 1.8538048267364502 172.7009874956516 446.06689250434863 97.57576381967058 282.40748018032946 492.08547574853236 1207.5295962514679 DOWN 0.24 0.76 0.0 GO:2000241 4 regulation of reproductive process 54 57 3 3 2 3 2 2 66 55 2424 0.8065 0.45367 0.66383 3.51 315852;170913 ttk;abcb1a TTK_32727;ABCB1A_7938 472.1665 472.1665 206.982 375.02751643112805 407.6359770214402 363.754396933875 282.325 282.325 118.025 232.35528829789953 242.34391164311123 225.37081698302757 1819.8200000000002 1819.8200000000002 1531.55 407.6753436252911 1749.671805595616 395.4208485191557 737.351;206.982 446.625;118.025 2108.09;1531.55 0 2 0 2 315852;170913 TTK_32727;ABCB1A_7938 472.1665 472.1665 375.02751643112805 282.325 282.325 232.35528829789953 1819.8200000000002 1819.8200000000002 407.6753436252911 737.351;206.982 446.625;118.025 2108.09;1531.55 0 Linear,1(0.5);Poly 2,1(0.5) 1.6888660644289075 3.398630976676941 1.5111545324325562 1.8874764442443848 0.26609977575122995 1.6993154883384705 -47.59512000000001 991.92812 -39.702999999999975 604.353 1254.8108 2384.8292 DOWN 0.0 1.0 0.0 GO:0048519 4 negative regulation of biological process 1024 1094 70 67 43 45 32 32 36 1062 1417 0.79363 0.28348 0.53527 2.93 684352;315852;688621;360243;24832;25671;295703;25682;25154;304545;259241;24314;316351;81687;24426;156275;25283;24367;312495;245920;84032;24854;306575;113902;29397;24232;246142;25612;29657;29221;81639;170913 twf2;ttk;tslp;top2a;thy1;smad1;serping1;ppard;pgr;oasl;nr1d2;nqo1;npas2;mmp9;gstp1;ggt7;gclc;fgg;cyp26b1;cxcl10;col3a1;clu;ckap2;ces1d;ccl11;c3;bmf;asns;arntl;arg1;alox15;abcb1a TWF2_10109;TTK_32727;TSLP_32811;TOP2A_10059;THY1_33010;SMAD1_32578;SERPING1_32597;PPARD_9536;PGR_32824;OASL_9389;NR1D2_9358;NQO1_33055;NPAS2_9350;MMP9_32531;GSTP1_8762;GGT7_33026;GCLC_8699;FGG_8639;CYP26B1_8418;CXCL10_8408;COL3A1_8354;CLU_32773;CKAP2_8324;CES1D_32914;CCL11_33230;C3_8175;BMF_8152;ASNS_8091;ARNTL_8086;ARG1_33267;ALOX15_8036;ABCB1A_7938 252.75112812500015 114.505 5.72311E-12 309.3431778557856 253.2912765354969 307.23306826067255 149.0932912500002 38.8425 5.72311E-12 204.09143609753363 148.80874797950855 200.6035837688644 741.537 280.71900000000005 5.72313E-12 875.1320050834028 733.1751691110715 876.8078799558143 138.399;737.351;344.675;86.3883;5.72311E-12;21.9973;32.3997;94.1074;283.618;76.6126;29.1728;25.6813;21.0878;728.316;14.7631;109.609;131.7;42.4612;18.1872;670.528;212.603;935.649;32.2386;11.0684;986.476;234.759;119.401;191.145;22.9134;760.927;766.819;206.982 90.7363;446.625;244.2;26.6888;5.72311E-12;5.02186;13.7308;37.7692;138.711;28.4477;3.35457;7.73944;11.3305;443.137;9.42992;29.3336;39.9158;20.6424;10.0176;374.802;119.81;808.484;15.2683;4.18343;552.974;129.148;81.8286;113.564;11.4115;413.607;421.048;118.025 299.165;2108.09;560.435;262.273;5.72313E-12;80.1461;99.4885;148.485;1554.21;260.389;114.038;86.1211;43.5624;2039.06;25.7196;346.073;397.209;98.0534;36.7271;1955.3;1510.69;1071.05;76.7052;17.0564;2230.86;694.216;220.085;510.267;50.1592;2639.93;2662.07;1531.55 5 27 5 259241;24314;24426;312495;29397 NR1D2_9358;NQO1_33055;GSTP1_8762;CYP26B1_8418;CCL11_33230 214.85608000000002 25.6813 431.38687039771736 116.703106 9.42992 243.89680076731673 498.69316 86.1211 968.9806354429707 29.1728;25.6813;14.7631;18.1872;986.476 3.35457;7.73944;9.42992;10.0176;552.974 114.038;86.1211;25.7196;36.7271;2230.86 27 684352;315852;688621;360243;24832;25671;295703;25682;25154;304545;316351;81687;156275;25283;24367;245920;84032;24854;306575;113902;24232;246142;25612;29657;29221;81639;170913 TWF2_10109;TTK_32727;TSLP_32811;TOP2A_10059;THY1_33010;SMAD1_32578;SERPING1_32597;PPARD_9536;PGR_32824;OASL_9389;NPAS2_9350;MMP9_32531;GGT7_33026;GCLC_8699;FGG_8639;CXCL10_8408;COL3A1_8354;CLU_32773;CKAP2_8324;CES1D_32914;C3_8175;BMF_8152;ASNS_8091;ARNTL_8086;ARG1_33267;ALOX15_8036;ABCB1A_7938 259.76872962962983 131.7 291.7850163128256 155.0914737037039 81.8286 200.6808711835779 786.5080814814816 346.073 869.0483859415299 138.399;737.351;344.675;86.3883;5.72311E-12;21.9973;32.3997;94.1074;283.618;76.6126;21.0878;728.316;109.609;131.7;42.4612;670.528;212.603;935.649;32.2386;11.0684;234.759;119.401;191.145;22.9134;760.927;766.819;206.982 90.7363;446.625;244.2;26.6888;5.72311E-12;5.02186;13.7308;37.7692;138.711;28.4477;11.3305;443.137;29.3336;39.9158;20.6424;374.802;119.81;808.484;15.2683;4.18343;129.148;81.8286;113.564;11.4115;413.607;421.048;118.025 299.165;2108.09;560.435;262.273;5.72313E-12;80.1461;99.4885;148.485;1554.21;260.389;43.5624;2039.06;346.073;397.209;98.0534;1955.3;1510.69;1071.05;76.7052;17.0564;694.216;220.085;510.267;50.1592;2639.93;2662.07;1531.55 0 Exp 2,4(0.13);Exp 4,12(0.38);Exp 5,2(0.07);Hill,3(0.1);Linear,2(0.07);Poly 2,8(0.25);Power,1(0.04) 1.9281801891247654 63.42164969444275 1.5021449327468872 3.5281898975372314 0.5248896338817797 1.875340223312378 145.56918532494524 359.933070925055 78.37921641113338 219.807366088867 438.31923013835166 1044.7547698616486 DOWN 0.15625 0.84375 0.0 GO:0051051 5 negative regulation of transport 140 146 8 7 3 4 2 2 66 144 2335 0.24096 0.91024 0.43258 1.37 81687;25283 mmp9;gclc MMP9_32531;GCLC_8699 430.00800000000004 430.00800000000004 131.7 421.87121936439326 393.05945767126855 418.62266561614155 241.5264 241.5264 39.9158 285.12044483817715 216.55483441000257 282.92491917236435 1218.1345 1218.1345 397.209 1160.9639757979144 1116.4543553659805 1152.0241531647287 728.316;131.7 443.137;39.9158 2039.06;397.209 0 2 0 2 81687;25283 MMP9_32531;GCLC_8699 430.00800000000004 430.00800000000004 421.87121936439326 241.5264 241.5264 285.12044483817715 1218.1345 1218.1345 1160.9639757979144 728.316;131.7 443.137;39.9158 2039.06;397.209 0 Hill,1(0.5);Linear,1(0.5) 2.01265290279188 4.026035666465759 1.9746891260147095 2.05134654045105 0.05420497757616379 2.0130178332328796 -154.67567999999994 1014.69168 -153.63037599999998 636.683176 -390.8794799999996 2827.14848 DOWN 0.0 1.0 0.0 GO:0010942 6 positive regulation of cell death 222 238 21 21 11 12 7 7 61 231 2248 0.70029 0.45368 0.67685 2.94 360243;24314;81687;361921;24854;246142;252898 top2a;nqo1;mmp9;ect2;clu;bmf;acox2 TOP2A_10059;NQO1_33055;MMP9_32531;ECT2_8523;CLU_32773;BMF_8152;ACOX2_32902 378.4006857142857 119.401 10.0162 403.8619334278999 298.78903828217943 375.0287869624479 257.67269857142855 81.8286 3.29405 310.863705341194 197.7395020528194 281.1088016396803 857.7299428571429 262.273 37.7305 958.736777773531 695.7073577730192 895.2833066255083 86.3883;25.6813;728.316;10.0162;935.649;119.401;743.353 26.6888;7.73944;443.137;3.29405;808.484;81.8286;432.537 262.273;86.1211;2039.06;37.7305;1071.05;220.085;2287.79 1 6 1 24314 NQO1_33055 25.6813 25.6813 7.73944 7.73944 86.1211 86.1211 25.6813 7.73944 86.1211 6 360243;81687;361921;24854;246142;252898 TOP2A_10059;MMP9_32531;ECT2_8523;CLU_32773;BMF_8152;ACOX2_32902 437.18724999999995 423.8585 408.2843719103035 299.32824166666666 257.1828 318.41473597409157 986.3314166666665 666.6614999999999 981.8805440135993 86.3883;728.316;10.0162;935.649;119.401;743.353 26.6888;443.137;3.29405;808.484;81.8286;432.537 262.273;2039.06;37.7305;1071.05;220.085;2287.79 0 Exp 2,1(0.15);Exp 4,2(0.29);Hill,1(0.15);Linear,1(0.15);Poly 2,2(0.29) 1.7707509001278494 12.510504841804504 1.5319663286209106 2.1727771759033203 0.2659085574383018 1.6358354091644287 79.21557855462066 677.5857928739508 27.381642900147625 487.96375424270957 147.48779856429803 1567.9720871499876 DOWN 0.14285714285714285 0.8571428571428571 0.0 GO:1902882 6 regulation of response to oxidative stress 41 45 3 3 2 2 2 2 66 43 2436 0.88316 0.33942 0.33942 4.44 156275;252898 ggt7;acox2 GGT7_33026;ACOX2_32902 426.481 426.481 109.609 448.12467993628735 394.196992288299 445.7927931899993 230.93529999999998 230.93529999999998 29.3336 285.107858337472 210.39542636808545 283.62425507729404 1316.9315 1316.9315 346.073 1373.0012578451995 1218.017101438529 1365.8566314071709 109.609;743.353 29.3336;432.537 346.073;2287.79 0 2 0 2 156275;252898 GGT7_33026;ACOX2_32902 426.481 426.481 448.12467993628735 230.93529999999998 230.93529999999998 285.107858337472 1316.9315 1316.9315 1373.0012578451995 109.609;743.353 29.3336;432.537 346.073;2287.79 0 Exp 2,1(0.5);Exp 4,1(0.5) 1.7198543478991748 3.4627522230148315 1.5319663286209106 1.930785894393921 0.2820080194279699 1.7313761115074158 -194.58811999999995 1047.5501199999999 -164.20403199999993 626.0746319999998 -585.9511599999996 3219.81416 DOWN 0.0 1.0 0.0 GO:0033591 6 response to L-ascorbic acid 11 12 2 2 2 2 2 2 66 10 2469 0.99663 0.039009 0.039009 16.67 116669;24426 vwf;gstp1 VWF_32396;GSTP1_8762 17.21975 17.21975 14.7631 3.474227748003869 18.416864031620555 3.033825050261545 6.77318 6.77318 4.11644 3.757197739699095 5.478563049124788 3.280924984850024 59.8988 59.8988 25.7196 48.33668819106251 76.55416397515528 42.20939619314876 0.0 14.7631 0.5 17.21975 19.6764;14.7631 4.11644;9.42992 94.078;25.7196 1 1 1 24426 GSTP1_8762 14.7631 14.7631 9.42992 9.42992 25.7196 25.7196 14.7631 9.42992 25.7196 1 116669 VWF_32396 19.6764 19.6764 4.11644 4.11644 94.078 94.078 19.6764 4.11644 94.078 0 Exp 4,1(0.5);Hill,1(0.5) 2.7163326735647977 5.619478464126587 2.0912885665893555 3.5281898975372314 1.0160426750092186 2.8097392320632935 12.404716 22.034784000000002 1.5659696000000007 11.9803904 -7.092431999999995 126.89003199999999 CONFLICT 0.5 0.5 0.0 GO:0050728 7 negative regulation of inflammatory response 47 48 3 3 2 2 2 2 66 46 2433 0.86523 0.36883 0.36883 4.17 25682;259241 ppard;nr1d2 PPARD_9536;NR1D2_9358 61.6401 61.6401 29.1728 45.915695993636 59.95591729106628 45.853878743088444 20.561885 20.561885 3.35457 24.334818245025993 19.669286527377523 24.302055776246462 131.2615 131.2615 114.038 24.357707291533064 130.3680619596542 24.324914006756977 94.1074;29.1728 37.7692;3.35457 148.485;114.038 1 1 1 259241 NR1D2_9358 29.1728 29.1728 3.35457 3.35457 114.038 114.038 29.1728 3.35457 114.038 1 25682 PPARD_9536 94.1074 94.1074 37.7692 37.7692 148.485 148.485 94.1074 37.7692 148.485 0 Exp 4,1(0.5);Exp 5,1(0.5) 2.057038809178166 4.121276021003723 1.9388991594314575 2.1823768615722656 0.1721647342514838 2.0606380105018616 -1.9958079999999967 125.27600799999999 -13.164452399999991 54.288222399999995 97.50344 165.01956 CONFLICT 0.5 0.5 0.0 GO:0019395 7 fatty acid oxidation 39 43 3 3 3 3 3 3 65 40 2439 0.97377 0.10543 0.10543 6.98 25682;81639;252898 ppard;alox15;acox2 PPARD_9536;ALOX15_8036;ACOX2_32902 534.7597999999999 743.353 94.1074 381.7964988162148 539.3481587587588 382.2913031592375 297.11806666666666 421.048 37.7692 224.67615641454555 297.7250094761428 223.17300927534384 1699.4483333333335 2287.79 148.485 1356.147788999537 1739.7348798798798 1377.726571436908 1.5 755.086 94.1074;766.819;743.353 37.7692;421.048;432.537 148.485;2662.07;2287.79 0 3 0 3 25682;81639;252898 PPARD_9536;ALOX15_8036;ACOX2_32902 534.7597999999999 743.353 381.7964988162148 297.11806666666666 421.048 224.67615641454555 1699.4483333333335 2287.79 1356.147788999537 94.1074;766.819;743.353 37.7692;421.048;432.537 148.485;2662.07;2287.79 0 Exp 2,2(0.67);Exp 5,1(0.34) 1.6462865364166455 4.973010420799255 1.5021449327468872 1.9388991594314575 0.2440074790418651 1.5319663286209106 102.7163897202912 966.8032102797087 42.87306146926716 551.3630718640661 164.82264289532804 3234.074023771339 DOWN 0.0 1.0 0.0 GO:0034097 5 response to cytokine 230 247 21 21 11 13 9 9 59 238 2241 0.88317 0.20823 0.29914 3.64 362282;81687;25283;24367;84032;29397;29221;81639;24646 pck1;mmp9;gclc;fgg;col3a1;ccl11;arg1;alox15;abcb1b PCK1_9439;MMP9_32531;GCLC_8699;FGG_8639;COL3A1_8354;CCL11_33230;ARG1_33267;ALOX15_8036;ABCB1B_7939 464.37114444444444 529.244 20.7941 366.5233313913083 400.0420137487967 386.69483546915876 264.0300833333333 356.883 8.25355 214.1562696656754 221.28372313012045 226.0039602434594 1406.2382111111112 1510.69 57.2115 1054.0520842126357 1210.1956608184837 1137.036951056234 529.244;728.316;131.7;42.4612;212.603;986.476;760.927;766.819;20.7941 356.883;443.137;39.9158;20.6424;119.81;552.974;413.607;421.048;8.25355 1021.06;2039.06;397.209;98.0534;1510.69;2230.86;2639.93;2662.07;57.2115 2 7 2 362282;29397 PCK1_9439;CCL11_33230 757.86 757.86 323.3118477754875 454.9285 454.9285 138.65727582965147 1625.96 1625.96 855.4577838794855 529.244;986.476 356.883;552.974 1021.06;2230.86 7 81687;25283;24367;84032;29221;81639;24646 MMP9_32531;GCLC_8699;FGG_8639;COL3A1_8354;ARG1_33267;ALOX15_8036;ABCB1B_7939 380.51718571428574 212.603 353.24506301994955 209.48767857142857 119.81 205.7380592583197 1343.460557142857 1510.69 1157.0260573250314 728.316;131.7;42.4612;212.603;760.927;766.819;20.7941 443.137;39.9158;20.6424;119.81;413.607;421.048;8.25355 2039.06;397.209;98.0534;1510.69;2639.93;2662.07;57.2115 0 Exp 2,2(0.23);Exp 4,1(0.12);Hill,2(0.23);Linear,2(0.23);Poly 2,1(0.12);Power,1(0.12) 2.1095675297924172 21.256325721740723 1.5021449327468872 6.191005229949951 1.4934730437356354 1.9746891260147095 224.9092346021231 703.8330542867658 124.11465381842535 403.94551284824126 717.5908494255226 2094.8855727966998 DOWN 0.2222222222222222 0.7777777777777778 0.0 GO:0010769 7 regulation of cell morphogenesis involved in differentiation 72 76 6 6 3 4 3 3 65 73 2406 0.85708 0.33127 0.45521 3.95 684352;24832;25671 twf2;thy1;smad1 TWF2_10109;THY1_33010;SMAD1_32578 53.46543333333525 21.9973 5.72311E-12 74.37239650477204 59.76911222730493 80.42978300436596 31.919386666668572 5.02186 5.72311E-12 50.99879155441185 37.76473162900317 53.88039751145032 126.43703333333525 80.1461 5.72313E-12 154.8614289870225 134.12438506858516 170.95122093285553 138.399;5.72311E-12;21.9973 90.7363;5.72311E-12;5.02186 299.165;5.72313E-12;80.1461 0 3 0 3 684352;24832;25671 TWF2_10109;THY1_33010;SMAD1_32578 53.46543333333525 21.9973 74.37239650477204 31.919386666668572 5.02186 50.99879155441185 126.43703333333525 80.1461 154.8614289870225 138.399;5.72311E-12;21.9973 90.7363;5.72311E-12;5.02186 299.165;5.72313E-12;80.1461 0 Exp 4,1(0.34);Hill,1(0.34);Poly 2,1(0.34) 1.7823165237657048 5.351078152656555 1.6932154893875122 1.863204002380371 0.08552316979816124 1.7946586608886719 -30.694856025587903 137.62572269225836 -25.79117875661062 89.62995208994776 -48.805170583649954 301.67923725032045 DOWN 0.0 1.0 0.0 GO:0140352 4 export from cell 85 90 5 5 2 5 2 2 66 88 2391 0.56577 0.70172 1.0 2.22 24367;170913 fgg;abcb1a FGG_8639;ABCB1A_7938 124.7216 124.7216 42.4612 116.33377332623576 122.31943082351174 116.28416049838884 69.33370000000001 69.33370000000001 20.6424 68.85989682957707 67.91181607987387 68.83053017095956 814.8017 814.8017 98.0534 1013.6351666678598 793.8712076420688 1013.2028819960437 42.4612;206.982 20.6424;118.025 98.0534;1531.55 0 2 0 2 24367;170913 FGG_8639;ABCB1A_7938 124.7216 124.7216 116.33377332623576 69.33370000000001 69.33370000000001 68.85989682957707 814.8017 814.8017 1013.6351666678598 42.4612;206.982 20.6424;118.025 98.0534;1531.55 0 Exp 4,1(0.5);Poly 2,1(0.5) 2.3061278483934395 4.7051146030426025 1.8874764442443848 2.8176381587982178 0.657723655961121 2.3525573015213013 -36.50878399999999 285.951984 -26.101248 164.768648 -590.024968 2219.6283679999997 DOWN 0.0 1.0 0.0 GO:0000302 5 response to reactive oxygen species 109 115 12 12 7 8 6 6 62 109 2370 0.96844 0.083669 0.12505 5.22 24314;81687;24426;361921;114494;29221 nqo1;mmp9;gstp1;ect2;ccna2;arg1 NQO1_33055;MMP9_32531;GSTP1_8762;ECT2_8523;CCNA2_8221;ARG1_33267 259.01460000000003 20.2222 10.0162 376.3262996697893 269.29179745993173 378.8984688923344 147.01656666666668 8.584679999999999 3.29405 218.14744125272517 153.51698614794884 221.5019856777805 814.4685999999998 72.18575 25.7196 1196.6400066522947 838.3162868136319 1188.2443698146456 4.5 744.6215 25.6813;728.316;14.7631;10.0162;14.384;760.927 7.73944;443.137;9.42992;3.29405;4.89199;413.607 86.1211;2039.06;25.7196;37.7305;58.2504;2639.93 2 4 2 24314;24426 NQO1_33055;GSTP1_8762 20.2222 20.2222 7.720333258350962 8.584679999999999 8.584679999999999 1.1953498714602508 55.92035 55.92035 42.710310243839245 25.6813;14.7631 7.73944;9.42992 86.1211;25.7196 4 81687;361921;114494;29221 MMP9_32531;ECT2_8523;CCNA2_8221;ARG1_33267 378.4108 371.35 423.07697671419885 216.23251 209.24949500000002 245.25492861236054 1193.742725 1048.6552 1345.5762104353541 728.316;10.0162;14.384;760.927 443.137;3.29405;4.89199;413.607 2039.06;37.7305;58.2504;2639.93 0 Exp 2,1(0.17);Exp 4,3(0.5);Hill,1(0.17);Linear,1(0.17) 1.996562087885715 12.528569102287292 1.513624906539917 3.5281898975372314 0.7522960840739988 1.8435909748077393 -42.10915425369444 560.1383542536945 -27.537740455895772 321.57087378922915 -143.04282455227144 1771.9800245522713 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0043648 7 dicarboxylic acid metabolic process 32 33 2 2 2 2 2 2 66 31 2448 0.94386 0.21961 0.21961 6.06 362282;25283 pck1;gclc PCK1_9439;GCLC_8699 330.472 330.472 131.7 281.106058220025 180.7316383216499 184.86823452630745 198.39939999999999 198.39939999999999 39.9158 224.12965653371262 79.00938740221477 147.39794001858155 709.1345 709.1345 397.209 441.1292725500087 474.1525247383928 290.1068384316486 0.5 330.472 529.244;131.7 356.883;39.9158 1021.06;397.209 1 1 1 362282 PCK1_9439 529.244 529.244 356.883 356.883 1021.06 1021.06 529.244 356.883 1021.06 1 25283 GCLC_8699 131.7 131.7 39.9158 39.9158 397.209 397.209 131.7 39.9158 397.209 0 Hill,1(0.5);Linear,1(0.5) 1.7838270070247648 3.5861016511917114 1.611412525177002 1.9746891260147095 0.2568753478987416 1.7930508255958557 -59.12112000000002 720.06512 -112.22845600000002 509.02725599999997 97.76052000000016 1320.50848 CONFLICT 0.5 0.5 0.0 GO:0001890 5 placenta development 22 23 5 5 4 5 4 4 64 19 2460 0.99973 0.0028065 0.0028065 17.39 116669;25682;24646;170913 vwf;ppard;abcb1b;abcb1a VWF_32396;PPARD_9536;ABCB1B_7939;ABCB1A_7938 85.38997499999999 57.45075 19.6764 88.22606388992523 71.23550653379137 87.95213742488936 42.041047500000005 23.011375 4.11644 52.82575306270946 35.06114038161967 52.32898387202882 457.831125 121.28150000000001 57.2115 716.7937098557221 405.270844325023 691.321146358249 0.5 20.23525 1.5 57.45075 19.6764;94.1074;20.7941;206.982 4.11644;37.7692;8.25355;118.025 94.078;148.485;57.2115;1531.55 0 4 0 4 116669;25682;24646;170913 VWF_32396;PPARD_9536;ABCB1B_7939;ABCB1A_7938 85.38997499999999 57.45075 88.22606388992523 42.041047500000005 23.011375 52.82575306270946 457.831125 121.28150000000001 716.7937098557221 19.6764;94.1074;20.7941;206.982 4.11644;37.7692;8.25355;118.025 94.078;148.485;57.2115;1531.55 0 Exp 5,1(0.25);Hill,2(0.5);Poly 2,1(0.25) 2.6236323316123333 12.108669400215149 1.8874764442443848 6.191005229949951 2.1109999402423627 2.0150938630104065 -1.0715676121267137 171.8515176121267 -9.728190501455273 93.81028550145528 -244.62671065860775 1160.2889606586077 DOWN 0.0 1.0 0.0 GO:0050896 2 response to stimulus 1203 1308 95 93 62 62 47 47 21 1261 1218 0.99914 0.0019873 0.0030349 3.59 116669;684352;688621;360243;25671;89776;295703;25682;299112;288583;363131;25154;362282;304545;300795;338475;24314;316351;313108;81687;291234;316273;293502;362376;24426;25283;24367;25315;361921;312495;24296;245920;84032;24854;170945;113902;114494;29397;686019;24232;246142;25612;29657;29221;81639;24646;170913 vwf;twf2;tslp;top2a;smad1;slc22a7;serping1;ppard;pole2;plod3;pik3r4;pgr;pck1;oasl;pclaf;nrep;nqo1;npas2;mms22l;mmp9;mki67;mcm3;kif22;herc6;gstp1;gclc;fgg;ephx1;ect2;cyp26b1;cyp1a1;cxcl10;col3a1;clu;chrna2;ces1d;ccna2;ccl11;casq1;c3;bmf;asns;arntl;arg1;alox15;abcb1b;abcb1a VWF_32396;TWF2_10109;TSLP_32811;TOP2A_10059;SMAD1_32578;SLC22A7_9847;SERPING1_32597;PPARD_9536;POLE2_9520;PLOD3_9507;PIK3R4_9484;PGR_32824;PCK1_9439;OASL_9389;NS5ATP9_9367;NREP_9364;NQO1_33055;NPAS2_9350;MMS22L_33129;MMP9_32531;MKI67_9232;MCM3_9207;KIF22_8963;HERC6_8794;GSTP1_8762;GCLC_8699;FGG_8639;EPHX1_8567;ECT2_8523;CYP26B1_8418;CYP1A1_8415;CXCL10_8408;COL3A1_8354;CLU_32773;CHRNA2_32401;CES1D_32914;CCNA2_8221;CCL11_33230;CASQ1_32992;C3_8175;BMF_8152;ASNS_8091;ARNTL_8086;ARG1_33267;ALOX15_8036;ABCB1B_7939;ABCB1A_7938 229.3843340483319 94.1074 2.71598E-7 300.46259921282774 186.1638886819541 267.6931909037896 141.6152174525872 37.7692 2.71598E-7 207.62076074148348 111.39685493382632 178.19038312269117 586.7864170270553 240.486 2.71599E-7 746.0316569252227 502.889643784133 721.6205489898275 19.6764;138.399;344.675;86.3883;21.9973;49.1516;32.3997;94.1074;2.71598E-7;882.629;955.628;283.618;529.244;76.6126;292.216;61.543;25.6813;21.0878;126.653;728.316;21.9311;197.273;17.3097;39.6865;14.7631;131.7;42.4612;39.2381;10.0162;18.1872;12.8863;670.528;212.603;935.649;163.479;11.0684;14.384;986.476;147.66;234.759;119.401;191.145;22.9134;760.927;766.819;20.7941;206.982 4.11644;90.7363;244.2;26.6888;5.02186;13.5995;13.7308;37.7692;2.71598E-7;625.677;735.228;138.711;356.883;28.4477;147.515;25.6719;7.73944;11.3305;85.587;443.137;6.82654;116.413;3.12114;15.7729;9.42992;39.9158;20.6424;18.9587;3.29405;10.0176;9.13136;374.802;119.81;808.484;101.968;4.18343;4.89199;552.974;96.6023;129.148;81.8286;113.564;11.4115;413.607;421.048;8.25355;118.025 94.078;299.165;560.435;262.273;80.1461;161.307;99.4885;148.485;2.71599E-7;1106.02;1288.97;1554.21;1021.06;260.389;658.494;148.788;86.1211;43.5624;240.486;2039.06;76.1794;496.915;90.6321;157.407;25.7196;397.209;98.0534;81.6965;37.7305;36.7271;19.3234;1955.3;1510.69;1071.05;414.362;17.0564;58.2504;2230.86;285.773;694.216;220.085;510.267;50.1592;2639.93;2662.07;57.2115;1531.55 7 40 7 362282;24314;24426;25315;312495;24296;29397 PCK1_9439;NQO1_33055;GSTP1_8762;EPHX1_8567;CYP26B1_8418;CYP1A1_8415;CCL11_33230 232.3537142857143 25.6813 382.5855695287588 137.87628857142857 10.0176 223.89305943798138 500.21538571428573 81.6965 845.0115158906168 529.244;25.6813;14.7631;39.2381;18.1872;12.8863;986.476 356.883;7.73944;9.42992;18.9587;10.0176;9.13136;552.974 1021.06;86.1211;25.7196;81.6965;36.7271;19.3234;2230.86 40 116669;684352;688621;360243;25671;89776;295703;25682;299112;288583;363131;25154;304545;300795;338475;316351;313108;81687;291234;316273;293502;362376;25283;24367;361921;245920;84032;24854;170945;113902;114494;686019;24232;246142;25612;29657;29221;81639;24646;170913 VWF_32396;TWF2_10109;TSLP_32811;TOP2A_10059;SMAD1_32578;SLC22A7_9847;SERPING1_32597;PPARD_9536;POLE2_9520;PLOD3_9507;PIK3R4_9484;PGR_32824;OASL_9389;NS5ATP9_9367;NREP_9364;NPAS2_9350;MMS22L_33129;MMP9_32531;MKI67_9232;MCM3_9207;KIF22_8963;HERC6_8794;GCLC_8699;FGG_8639;ECT2_8523;CXCL10_8408;COL3A1_8354;CLU_32773;CHRNA2_32401;CES1D_32914;CCNA2_8221;CASQ1_32992;C3_8175;BMF_8152;ASNS_8091;ARNTL_8086;ARG1_33267;ALOX15_8036;ABCB1B_7939;ABCB1A_7938 228.86469250678996 123.027 289.76005778819956 142.26953000678995 60.87219999999999 207.67392456791353 601.9363475067901 261.331 738.258507505839 19.6764;138.399;344.675;86.3883;21.9973;49.1516;32.3997;94.1074;2.71598E-7;882.629;955.628;283.618;76.6126;292.216;61.543;21.0878;126.653;728.316;21.9311;197.273;17.3097;39.6865;131.7;42.4612;10.0162;670.528;212.603;935.649;163.479;11.0684;14.384;147.66;234.759;119.401;191.145;22.9134;760.927;766.819;20.7941;206.982 4.11644;90.7363;244.2;26.6888;5.02186;13.5995;13.7308;37.7692;2.71598E-7;625.677;735.228;138.711;28.4477;147.515;25.6719;11.3305;85.587;443.137;6.82654;116.413;3.12114;15.7729;39.9158;20.6424;3.29405;374.802;119.81;808.484;101.968;4.18343;4.89199;96.6023;129.148;81.8286;113.564;11.4115;413.607;421.048;8.25355;118.025 94.078;299.165;560.435;262.273;80.1461;161.307;99.4885;148.485;2.71599E-7;1106.02;1288.97;1554.21;260.389;658.494;148.788;43.5624;240.486;2039.06;76.1794;496.915;90.6321;157.407;397.209;98.0534;37.7305;1955.3;1510.69;1071.05;414.362;17.0564;58.2504;285.773;694.216;220.085;510.267;50.1592;2639.93;2662.07;57.2115;1531.55 0 Exp 2,5(0.11);Exp 4,16(0.35);Exp 5,2(0.05);Hill,7(0.15);Linear,2(0.05);Poly 2,14(0.3);Power,1(0.03) 2.0023873558218503 107.58512365818024 1.5018656253814697 15.48720932006836 2.1134282960687005 1.7986326217651367 143.48346406828762 315.28520402837614 82.25740047191513 200.97303443325924 373.499410489722 800.0734235643885 DOWN 0.14893617021276595 0.851063829787234 0.0 GO:0022414 2 reproductive process 343 368 32 29 20 22 15 15 53 353 2126 0.97098 0.056684 0.079507 4.08 116669;315852;360243;25671;25682;25154;81687;291234;312495;24296;24854;29657;29221;24646;170913 vwf;ttk;top2a;smad1;ppard;pgr;mmp9;mki67;cyp26b1;cyp1a1;clu;arntl;arg1;abcb1b;abcb1a VWF_32396;TTK_32727;TOP2A_10059;SMAD1_32578;PPARD_9536;PGR_32824;MMP9_32531;MKI67_9232;CYP26B1_8418;CYP1A1_8415;CLU_32773;ARNTL_8086;ARG1_33267;ABCB1B_7939;ABCB1A_7938 264.78163333333333 86.3883 12.8863 340.0993622903243 252.4161554850658 333.6563450985283 165.85505666666668 26.6888 4.11644 245.49122950584766 154.87111791472927 233.7793338771739 784.5648466666667 148.485 19.3234 939.8212387481719 769.5000803911521 945.0019586578779 19.6764;737.351;86.3883;21.9973;94.1074;283.618;728.316;21.9311;18.1872;12.8863;935.649;22.9134;760.927;20.7941;206.982 4.11644;446.625;26.6888;5.02186;37.7692;138.711;443.137;6.82654;10.0176;9.13136;808.484;11.4115;413.607;8.25355;118.025 94.078;2108.09;262.273;80.1461;148.485;1554.21;2039.06;76.1794;36.7271;19.3234;1071.05;50.1592;2639.93;57.2115;1531.55 2 13 2 312495;24296 CYP26B1_8418;CYP1A1_8415 15.536750000000001 15.536750000000001 3.7483023363917627 9.574480000000001 9.574480000000001 0.6266663137587598 28.02525 28.02525 12.306274287736318 18.1872;12.8863 10.0176;9.13136 36.7271;19.3234 13 116669;315852;360243;25671;25682;25154;81687;291234;24854;29657;29221;24646;170913 VWF_32396;TTK_32727;TOP2A_10059;SMAD1_32578;PPARD_9536;PGR_32824;MMP9_32531;MKI67_9232;CLU_32773;ARNTL_8086;ARG1_33267;ABCB1B_7939;ABCB1A_7938 303.127 94.1074 350.7101391980135 189.89822230769232 37.7692 256.1510984946767 900.9555538461539 262.273 959.3718138650013 19.6764;737.351;86.3883;21.9973;94.1074;283.618;728.316;21.9311;935.649;22.9134;760.927;20.7941;206.982 4.11644;446.625;26.6888;5.02186;37.7692;138.711;443.137;6.82654;808.484;11.4115;413.607;8.25355;118.025 94.078;2108.09;262.273;80.1461;148.485;1554.21;2039.06;76.1794;1071.05;50.1592;2639.93;57.2115;1531.55 0 Exp 2,1(0.07);Exp 4,6(0.4);Exp 5,1(0.07);Hill,2(0.14);Linear,2(0.14);Poly 2,3(0.2) 2.3544289183544516 46.87635576725006 1.5111545324325562 15.48720932006836 3.6212284712435707 1.9388991594314575 92.66760894905806 436.89565771760863 41.619353380558934 290.0907599527744 308.9496778717307 1260.1800154616028 DOWN 0.13333333333333333 0.8666666666666667 0.0 GO:0002682 4 regulation of immune system process 334 363 23 23 14 16 10 10 58 353 2126 0.62574 0.51079 0.86102 2.75 688621;24832;295703;81687;312495;245920;84032;24232;29221;81639 tslp;thy1;serping1;mmp9;cyp26b1;cxcl10;col3a1;c3;arg1;alox15 TSLP_32811;THY1_33010;SERPING1_32597;MMP9_32531;CYP26B1_8418;CXCL10_8408;COL3A1_8354;C3_8175;ARG1_33267;ALOX15_8036 376.9213900000006 289.717 5.72311E-12 324.357334578463 403.2195292677222 333.5197225190636 216.95004000000057 186.67399999999998 5.72311E-12 184.23477755551818 235.885952902894 190.22817704602468 1219.7916600000005 1102.453 5.72313E-12 1067.0493213026539 1251.1439089521496 1117.2361921619713 344.675;5.72311E-12;32.3997;728.316;18.1872;670.528;212.603;234.759;760.927;766.819 244.2;5.72311E-12;13.7308;443.137;10.0176;374.802;119.81;129.148;413.607;421.048 560.435;5.72313E-12;99.4885;2039.06;36.7271;1955.3;1510.69;694.216;2639.93;2662.07 1 9 1 312495 CYP26B1_8418 18.1872 18.1872 10.0176 10.0176 36.7271 36.7271 18.1872 10.0176 36.7271 9 688621;24832;295703;81687;245920;84032;24232;29221;81639 TSLP_32811;THY1_33010;SERPING1_32597;MMP9_32531;CXCL10_8408;COL3A1_8354;C3_8175;ARG1_33267;ALOX15_8036 416.7807444444451 344.675 316.99368924083046 239.94253333333396 244.2 179.54914086291157 1351.2432777777785 1510.69 1042.3645465572818 344.675;5.72311E-12;32.3997;728.316;670.528;212.603;234.759;760.927;766.819 244.2;5.72311E-12;13.7308;443.137;374.802;119.81;129.148;413.607;421.048 560.435;5.72313E-12;99.4885;2039.06;1955.3;1510.69;694.216;2639.93;2662.07 0 Exp 2,4(0.4);Exp 4,2(0.2);Hill,1(0.1);Linear,1(0.1);Poly 2,2(0.2) 1.7323229779471623 17.43838655948639 1.5021449327468872 2.090334892272949 0.21404834182232907 1.7020898461341858 175.88263120235067 577.9601487976504 102.76014182717901 331.1399381728222 558.4276387135708 1881.1556812864303 DOWN 0.1 0.9 0.0 GO:0034754 5 cellular hormone metabolic process 34 41 5 5 3 4 3 3 65 38 2441 0.97761 0.094502 0.094502 7.32 286989;312495;24296 ugt2b7;cyp26b1;cyp1a1 UGT2B7_33032;CYP26B1_8418;CYP1A1_8415 21.928700000000003 18.1872 12.8863 11.384022119180901 23.37409690812721 11.183824057010318 11.307286666666668 10.0176 9.13136 3.0338444532528897 11.645912869762746 3.0381636880909113 53.6915 36.7271 19.3234 45.29891125192746 59.12037223624433 44.911876900270606 1.5 26.4499 34.7126;18.1872;12.8863 14.7729;10.0176;9.13136 105.024;36.7271;19.3234 3 0 3 286989;312495;24296 UGT2B7_33032;CYP26B1_8418;CYP1A1_8415 21.928700000000003 18.1872 11.384022119180901 11.307286666666668 10.0176 3.0338444532528897 53.6915 36.7271 45.29891125192746 34.7126;18.1872;12.8863 14.7729;10.0176;9.13136 105.024;36.7271;19.3234 0 0 Exp 4,3(1) 5.769007107326074 23.50835657119751 2.090334892272949 15.48720932006836 6.898674202165192 5.930812358856201 9.046466259459297 34.810933740540705 7.874168479607249 14.740404853726087 2.430956333617324 104.95204366638268 UP 1.0 0.0 0.0 GO:0019932 6 second-messenger-mediated signaling 68 74 4 4 3 3 2 2 66 72 2407 0.6836 0.59487 1.0 2.7 245920;686019 cxcl10;casq1 CXCL10_8408;CASQ1_32992 409.094 409.094 147.66 369.7235084654478 217.31686837414392 251.27382729348898 235.70215000000002 235.70215000000002 96.6023 196.7168943940632 133.6642733558495 133.693978921832 1120.5365 1120.5365 285.773 1180.5338630740332 508.18864311849137 802.3218844140716 670.528;147.66 374.802;96.6023 1955.3;285.773 0 2 0 2 245920;686019 CXCL10_8408;CASQ1_32992 409.094 409.094 369.7235084654478 235.70215000000002 235.70215000000002 196.7168943940632 1120.5365 1120.5365 1180.5338630740332 670.528;147.66 374.802;96.6023 1955.3;285.773 0 Exp 2,1(0.5);Poly 2,1(0.5) 2.076999616348261 4.180871486663818 1.8538048267364502 2.327066659927368 0.3346466515260748 2.090435743331909 -103.31663999999995 921.5046399999999 -36.93355599999995 508.337856 -515.59996 2756.67296 DOWN 0.0 1.0 0.0 GO:0031348 6 negative regulation of defense response 64 68 5 5 4 4 4 4 64 64 2415 0.96674 0.10592 0.10592 5.88 295703;25682;259241;29221 serping1;ppard;nr1d2;arg1 SERPING1_32597;PPARD_9536;NR1D2_9358;ARG1_33267 229.151725 63.253550000000004 29.1728 355.7737308092451 275.5455933142993 381.1750690918534 117.11539250000001 25.75 3.35457 198.1859314586925 142.63872713537947 212.65744797991786 750.485375 131.2615 99.4885 1259.797289890413 915.0573303592671 1350.8078517839251 2.5 427.5172 32.3997;94.1074;29.1728;760.927 13.7308;37.7692;3.35457;413.607 99.4885;148.485;114.038;2639.93 1 3 1 259241 NR1D2_9358 29.1728 29.1728 3.35457 3.35457 114.038 114.038 29.1728 3.35457 114.038 3 295703;25682;29221 SERPING1_32597;PPARD_9536;ARG1_33267 295.8113666666667 94.1074 403.98189852779706 155.03566666666669 37.7692 224.25167108624484 962.6345 148.485 1452.7870835030335 32.3997;94.1074;760.927 13.7308;37.7692;413.607 99.4885;148.485;2639.93 0 Exp 2,1(0.25);Exp 4,2(0.5);Exp 5,1(0.25) 1.8213845162669808 7.353218078613281 1.513624906539917 2.1823768615722656 0.28770290104943663 1.8286081552505493 -119.50653119306017 577.8099811930603 -77.10682032951865 311.3376053295187 -484.1159690926045 1985.0867190926044 DOWN 0.25 0.75 0.0 GO:0001822 5 kidney development 48 53 6 5 3 5 3 3 65 50 2429 0.94893 0.16659 0.16659 5.66 25671;81687;312495 smad1;mmp9;cyp26b1 SMAD1_32578;MMP9_32531;CYP26B1_8418 256.16683333333333 21.9973 18.1872 408.8976105378012 352.27361163359416 433.7276160735197 152.72548666666668 10.0176 5.02186 251.51615189079712 213.19075068613748 265.2239863706593 718.6444 80.1461 36.7271 1143.7195110396474 981.3839754401899 1219.9990061799954 1.5 375.15665 21.9973;728.316;18.1872 5.02186;443.137;10.0176 80.1461;2039.06;36.7271 1 2 1 312495 CYP26B1_8418 18.1872 18.1872 10.0176 10.0176 36.7271 36.7271 18.1872 10.0176 36.7271 2 25671;81687 SMAD1_32578;MMP9_32531 375.15665 375.15665 499.44274244886674 224.07943 224.07943 309.7941864344936 1059.60305 1059.60305 1385.1613024505864 21.9973;728.316 5.02186;443.137 80.1461;2039.06 0 Exp 4,2(0.67);Linear,1(0.34) 1.9363731200929573 5.834896922111511 1.6932154893875122 2.090334892272949 0.2188918155397579 2.05134654045105 -206.5443718760555 718.8780385427222 -131.89183261272683 437.34280594606014 -575.5960644492886 2012.8848644492884 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0008150 1 biological_process 2293 2547 141 138 94 93 68 68 0 2479 0 1.0 1.0 1.0 2.67 116669;286989;684352;315852;688621;360243;24832;295661;25671;313089;294881;170551;89776;295703;291463;25682;299112;288583;363131;25154;362282;304545;300795;338475;259241;24314;316351;313108;81687;291234;316273;293502;362376;24426;156275;25283;81919;84493;24367;309186;29243;25315;361921;64191;312495;24296;245920;84032;24854;306575;170945;113902;297594;114494;29397;686019;24232;246142;116599;25612;29657;29221;81639;26760;286921;252898;24646;170913 vwf;ugt2b7;twf2;ttk;tslp;top2a;thy1;spc25;smad1;slc7a13;slc7a12;slc5a6;slc22a7;serping1;ppic;ppard;pole2;plod3;pik3r4;pgr;pck1;oasl;pclaf;nrep;nr1d2;nqo1;npas2;mms22l;mmp9;mki67;mcm3;kif22;herc6;gstp1;ggt7;gclc;fut1;fmo3;fgg;fermt3;f10;ephx1;ect2;dhcr7;cyp26b1;cyp1a1;cxcl10;col3a1;clu;ckap2;chrna2;ces1d;cdca3;ccna2;ccl11;casq1;c3;bmf;blvra;asns;arntl;arg1;alox15;akr7a3;akr1b8;acox2;abcb1b;abcb1a VWF_32396;UGT2B7_33032;TWF2_10109;TTK_32727;TSLP_32811;TOP2A_10059;THY1_33010;SPC25_9925;SMAD1_32578;SLC7A13_32952;SLC7A12_32838;SLC5A6_9881;SLC22A7_9847;SERPING1_32597;PPIC_9541;PPARD_9536;POLE2_9520;PLOD3_9507;PIK3R4_9484;PGR_32824;PCK1_9439;OASL_9389;NS5ATP9_9367;NREP_9364;NR1D2_9358;NQO1_33055;NPAS2_9350;MMS22L_33129;MMP9_32531;MKI67_9232;MCM3_9207;KIF22_8963;HERC6_8794;GSTP1_8762;GGT7_33026;GCLC_8699;FUT1_8668;FMO3_8654;FGG_8639;FERMT3_32542;F10_8585;EPHX1_8567;ECT2_8523;DHCR7_8466;CYP26B1_8418;CYP1A1_8415;CXCL10_8408;COL3A1_8354;CLU_32773;CKAP2_8324;CHRNA2_32401;CES1D_32914;CDCA3_8260;CCNA2_8221;CCL11_33230;CASQ1_32992;C3_8175;BMF_8152;BLVRA_8151;ASNS_8091;ARNTL_8086;ARG1_33267;ALOX15_8036;AKR7A3_8015;AKR1B8_8013;ACOX2_32902;ABCB1B_7939;ABCB1A_7938 238.52565882752359 114.505 5.72311E-12 285.8021332594036 196.16354990357829 253.98116784979672 146.11754103340593 39.169349999999994 5.72311E-12 196.41578654263466 116.60030823576166 170.7150442847063 595.7543058863471 250.4375 5.72313E-12 715.9768502849594 506.0945527694208 670.4439733113891 19.6764;34.7126;138.399;737.351;344.675;86.3883;5.72311E-12;35.8903;21.9973;397.931;37.9163;120.077;49.1516;32.3997;628.678;94.1074;2.71598E-7;882.629;955.628;283.618;529.244;76.6126;292.216;61.543;29.1728;25.6813;21.0878;126.653;728.316;21.9311;197.273;17.3097;39.6865;14.7631;109.609;131.7;240.861;418.073;42.4612;539.113;104.19;39.2381;10.0162;161.702;18.1872;12.8863;670.528;212.603;935.649;32.2386;163.479;11.0684;56.6562;14.384;986.476;147.66;234.759;119.401;415.991;191.145;22.9134;760.927;766.819;52.7573;542.408;743.353;20.7941;206.982 4.11644;14.7729;90.7363;446.625;244.2;26.6888;5.72311E-12;11.5744;5.02186;280.111;15.3983;82.2177;13.5995;13.7308;389.239;37.7692;2.71598E-7;625.677;735.228;138.711;356.883;28.4477;147.515;25.6719;3.35457;7.73944;11.3305;85.587;443.137;6.82654;116.413;3.12114;15.7729;9.42992;29.3336;39.9158;78.9726;293.29;20.6424;334.248;38.4229;18.9587;3.29405;50.9087;10.0176;9.13136;374.802;119.81;808.484;15.2683;101.968;4.18343;22.3266;4.89199;552.974;96.6023;129.148;81.8286;288.048;113.564;11.4115;413.607;421.048;12.408;441.021;432.537;8.25355;118.025 94.078;105.024;299.165;2108.09;560.435;262.273;5.72313E-12;124.006;80.1461;668.129;132.15;221.286;161.307;99.4885;1509.86;148.485;2.71599E-7;1106.02;1288.97;1554.21;1021.06;260.389;658.494;148.788;114.038;86.1211;43.5624;240.486;2039.06;76.1794;496.915;90.6321;157.407;25.7196;346.073;397.209;847.87;712.184;98.0534;1187.86;163.044;81.6965;37.7305;481.517;36.7271;19.3234;1955.3;1510.69;1071.05;76.7052;414.362;17.0564;150.565;58.2504;2230.86;285.773;694.216;220.085;720.942;510.267;50.1592;2639.93;2662.07;216.887;758.311;2287.79;57.2115;1531.55 11 57 11 286989;362282;259241;24314;24426;25315;312495;24296;29397;26760;286921 UGT2B7_33032;PCK1_9439;NR1D2_9358;NQO1_33055;GSTP1_8762;EPHX1_8567;CYP26B1_8418;CYP1A1_8415;CCL11_33230;AKR7A3_8015;AKR1B8_8013 207.77515454545457 34.7126 328.68193935506514 130.60822636363636 12.408 210.01835275173238 426.88797272727277 105.024 683.9092258715611 34.7126;529.244;29.1728;25.6813;14.7631;39.2381;18.1872;12.8863;986.476;52.7573;542.408 14.7729;356.883;3.35457;7.73944;9.42992;18.9587;10.0176;9.13136;552.974;12.408;441.021 105.024;1021.06;114.038;86.1211;25.7196;81.6965;36.7271;19.3234;2230.86;216.887;758.311 57 116669;684352;315852;688621;360243;24832;295661;25671;313089;294881;170551;89776;295703;291463;25682;299112;288583;363131;25154;304545;300795;338475;316351;313108;81687;291234;316273;293502;362376;156275;25283;81919;84493;24367;309186;29243;361921;64191;245920;84032;24854;306575;170945;113902;297594;114494;686019;24232;246142;116599;25612;29657;29221;81639;252898;24646;170913 VWF_32396;TWF2_10109;TTK_32727;TSLP_32811;TOP2A_10059;THY1_33010;SPC25_9925;SMAD1_32578;SLC7A13_32952;SLC7A12_32838;SLC5A6_9881;SLC22A7_9847;SERPING1_32597;PPIC_9541;PPARD_9536;POLE2_9520;PLOD3_9507;PIK3R4_9484;PGR_32824;OASL_9389;NS5ATP9_9367;NREP_9364;NPAS2_9350;MMS22L_33129;MMP9_32531;MKI67_9232;MCM3_9207;KIF22_8963;HERC6_8794;GGT7_33026;GCLC_8699;FUT1_8668;FMO3_8654;FGG_8639;FERMT3_32542;F10_8585;ECT2_8523;DHCR7_8466;CXCL10_8408;COL3A1_8354;CLU_32773;CKAP2_8324;CHRNA2_32401;CES1D_32914;CDCA3_8260;CCNA2_8221;CASQ1_32992;C3_8175;BMF_8152;BLVRA_8151;ASNS_8091;ARNTL_8086;ARG1_33267;ALOX15_8036;ACOX2_32902;ABCB1B_7939;ABCB1A_7938 244.45996667143163 126.653 279.6689549522548 149.1105666714316 78.9726 195.5107857313743 628.3425456188 285.773 723.2639908043625 19.6764;138.399;737.351;344.675;86.3883;5.72311E-12;35.8903;21.9973;397.931;37.9163;120.077;49.1516;32.3997;628.678;94.1074;2.71598E-7;882.629;955.628;283.618;76.6126;292.216;61.543;21.0878;126.653;728.316;21.9311;197.273;17.3097;39.6865;109.609;131.7;240.861;418.073;42.4612;539.113;104.19;10.0162;161.702;670.528;212.603;935.649;32.2386;163.479;11.0684;56.6562;14.384;147.66;234.759;119.401;415.991;191.145;22.9134;760.927;766.819;743.353;20.7941;206.982 4.11644;90.7363;446.625;244.2;26.6888;5.72311E-12;11.5744;5.02186;280.111;15.3983;82.2177;13.5995;13.7308;389.239;37.7692;2.71598E-7;625.677;735.228;138.711;28.4477;147.515;25.6719;11.3305;85.587;443.137;6.82654;116.413;3.12114;15.7729;29.3336;39.9158;78.9726;293.29;20.6424;334.248;38.4229;3.29405;50.9087;374.802;119.81;808.484;15.2683;101.968;4.18343;22.3266;4.89199;96.6023;129.148;81.8286;288.048;113.564;11.4115;413.607;421.048;432.537;8.25355;118.025 94.078;299.165;2108.09;560.435;262.273;5.72313E-12;124.006;80.1461;668.129;132.15;221.286;161.307;99.4885;1509.86;148.485;2.71599E-7;1106.02;1288.97;1554.21;260.389;658.494;148.788;43.5624;240.486;2039.06;76.1794;496.915;90.6321;157.407;346.073;397.209;847.87;712.184;98.0534;1187.86;163.044;37.7305;481.517;1955.3;1510.69;1071.05;76.7052;414.362;17.0564;150.565;58.2504;285.773;694.216;220.085;720.942;510.267;50.1592;2639.93;2662.07;2287.79;57.2115;1531.55 0 Exp 2,13(0.2);Exp 4,24(0.36);Exp 5,3(0.05);Hill,9(0.14);Linear,3(0.05);Poly 2,15(0.23);Power,1(0.02) 1.9798621193246349 150.51614797115326 1.5018656253814697 15.48720932006836 1.8293540684066831 1.8020069003105164 170.59480378127256 306.45651387377467 99.43247198840754 192.80261007840443 425.5774108488474 765.9312009238463 DOWN 0.16176470588235295 0.8382352941176471 0.0 GO:0014912 8 negative regulation of smooth muscle cell migration 13 14 2 2 2 2 2 2 66 12 2467 0.99463 0.051979 0.051979 14.29 25682;24426 ppard;gstp1 PPARD_9536;GSTP1_8762 54.435249999999996 54.435249999999996 14.7631 56.10489257849978 58.72202455795677 55.776393743442306 23.599559999999997 23.599559999999997 9.42992 20.038897061944308 25.13066058939096 19.92156764488009 87.10230000000001 87.10230000000001 25.7196 86.80824683507899 93.73500825147347 86.29997729479238 0.0 14.7631 0.5 54.435249999999996 94.1074;14.7631 37.7692;9.42992 148.485;25.7196 1 1 1 24426 GSTP1_8762 14.7631 14.7631 9.42992 9.42992 25.7196 25.7196 14.7631 9.42992 25.7196 1 25682 PPARD_9536 94.1074 94.1074 37.7692 37.7692 148.485 148.485 94.1074 37.7692 148.485 0 Exp 4,1(0.5);Exp 5,1(0.5) 2.615493151711451 5.467089056968689 1.9388991594314575 3.5281898975372314 1.1237982581915662 2.7335445284843445 -23.322164 132.19266399999998 -4.172934399999999 51.372054399999996 -33.20779199999998 207.412392 CONFLICT 0.5 0.5 0.0 GO:0033280 6 response to vitamin D 17 20 4 4 3 2 2 2 66 18 2461 0.98501 0.098041 0.098041 10.0 245920;170913 cxcl10;abcb1a CXCL10_8408;ABCB1A_7938 438.755 438.755 206.982 327.7765199918995 290.4508460563023 251.89125213887058 246.4135 246.4135 118.025 181.56875795273822 164.2617917829064 139.53281885824228 1743.425 1743.425 1531.55 299.6364985277995 1607.8529419223942 230.26607519824583 0.0 206.982 1.0 670.528 670.528;206.982 374.802;118.025 1955.3;1531.55 0 2 0 2 245920;170913 CXCL10_8408;ABCB1A_7938 438.755 438.755 327.7765199918995 246.4135 246.4135 181.56875795273822 1743.425 1743.425 299.6364985277995 670.528;206.982 374.802;118.025 1955.3;1531.55 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.8705648726231316 3.741281270980835 1.8538048267364502 1.8874764442443848 0.02380942907338021 1.8706406354904175 -15.52007999999995 893.03008 -5.227960000000024 498.05496000000005 1328.15 2158.7 DOWN 0.0 1.0 0.0 GO:0001819 6 positive regulation of cytokine production 132 142 8 8 5 5 3 3 65 139 2340 0.46854 0.74185 1.0 2.11 688621;24854;24232 tslp;clu;c3 TSLP_32811;CLU_32773;C3_8175 505.0276666666667 344.675 234.759 376.9568029699601 506.2782028238281 355.4393431245991 393.94399999999996 244.2 129.148 363.5819018818182 396.5595669072738 341.64317827047 775.2336666666666 694.216 560.435 264.7731411800169 744.1193145078131 274.7986996580908 344.675;935.649;234.759 244.2;808.484;129.148 560.435;1071.05;694.216 0 3 0 3 688621;24854;24232 TSLP_32811;CLU_32773;C3_8175 505.0276666666667 344.675 376.9568029699601 393.94399999999996 244.2 363.5819018818182 775.2336666666666 694.216 264.7731411800169 344.675;935.649;234.759 244.2;808.484;129.148 560.435;1071.05;694.216 0 Exp 2,1(0.34);Poly 2,2(0.67) 1.5945769854690406 4.787482857704163 1.5467612743377686 1.6858625411987305 0.0780775821907652 1.5548590421676636 78.46088779823504 931.5944455350984 -17.48765349092986 805.3756534909301 475.6146517711138 1074.8526815622195 DOWN 0.0 1.0 0.0 GO:0051775 3 response to redox state 5 6 2 2 2 2 2 2 66 4 2475 0.99966 0.0098306 0.0098306 33.33 316351;29657 npas2;arntl NPAS2_9350;ARNTL_8086 22.0006 22.0006 21.0878 1.290894139734257 21.423916196965006 1.0006394268836907 11.371 11.371 11.3305 0.05727564927575967 11.34541313100031 0.0443973452991045 46.8608 46.8608 43.5624 4.664642014131399 44.77695484670176 3.615807499598196 0.0 21.0878 0.0 21.0878 21.0878;22.9134 11.3305;11.4115 43.5624;50.1592 0 2 0 2 316351;29657 NPAS2_9350;ARNTL_8086 22.0006 22.0006 1.290894139734257 11.371 11.371 0.05727564927575967 46.8608 46.8608 4.664642014131399 21.0878;22.9134 11.3305;11.4115 43.5624;50.1592 0 Exp 4,2(1) 3.2587969495071403 6.527446746826172 3.0844674110412598 3.442979335784912 0.2535062131224778 3.263723373413086 20.211512 23.789687999999998 11.291620000000002 11.45038 40.39593599999999 53.325664 DOWN 0.0 1.0 0.0 GO:0015807 7 L-amino acid transport 11 11 2 2 2 2 2 2 66 9 2470 0.99742 0.033069 0.033069 18.18 313089;294881 slc7a13;slc7a12 SLC7A13_32952;SLC7A12_32838 217.92364999999998 217.92364999999998 37.9163 254.56883569684055 208.7994873280693 254.24160048882106 147.75465 147.75465 15.3983 187.1801452362002 141.0458080106979 186.9395347404346 400.1395 400.1395 132.15 378.9943854735846 386.55572249108513 378.5072075901284 0.0 37.9163 0.5 217.92364999999998 397.931;37.9163 280.111;15.3983 668.129;132.15 0 2 0 2 313089;294881 SLC7A13_32952;SLC7A12_32838 217.92364999999998 217.92364999999998 254.56883569684055 147.75465 147.75465 187.1801452362002 400.1395 400.1395 378.9943854735846 397.931;37.9163 280.111;15.3983 668.129;132.15 0 Exp 2,1(0.5);Exp 4,1(0.5) 2.131279231495183 4.2874157428741455 1.913203477859497 2.3742122650146484 0.32598243958399326 2.1437078714370728 -134.89075599999998 570.7380559999999 -111.66379599999996 407.173096 -125.11992000000009 925.3989200000001 DOWN 0.0 1.0 0.0 GO:1902475 7 L-alpha-amino acid transmembrane transport 11 11 2 2 2 2 2 2 66 9 2470 0.99742 0.033069 0.033069 18.18 313089;294881 slc7a13;slc7a12 SLC7A13_32952;SLC7A12_32838 217.92364999999998 217.92364999999998 37.9163 254.56883569684055 208.7994873280693 254.24160048882106 147.75465 147.75465 15.3983 187.1801452362002 141.0458080106979 186.9395347404346 400.1395 400.1395 132.15 378.9943854735846 386.55572249108513 378.5072075901284 0.0 37.9163 0.5 217.92364999999998 397.931;37.9163 280.111;15.3983 668.129;132.15 0 2 0 2 313089;294881 SLC7A13_32952;SLC7A12_32838 217.92364999999998 217.92364999999998 254.56883569684055 147.75465 147.75465 187.1801452362002 400.1395 400.1395 378.9943854735846 397.931;37.9163 280.111;15.3983 668.129;132.15 0 Exp 2,1(0.5);Exp 4,1(0.5) 2.131279231495183 4.2874157428741455 1.913203477859497 2.3742122650146484 0.32598243958399326 2.1437078714370728 -134.89075599999998 570.7380559999999 -111.66379599999996 407.173096 -125.11992000000009 925.3989200000001 DOWN 0.0 1.0 0.0 GO:0006805 4 xenobiotic metabolic process 43 62 4 4 3 3 3 3 65 59 2420 0.91845 0.22854 0.22854 4.84 24426;312495;24296 gstp1;cyp26b1;cyp1a1 GSTP1_8762;CYP26B1_8418;CYP1A1_8415 15.278866666666667 14.7631 12.8863 2.6878237746052673 15.972844526672834 2.808999863904672 9.526293333333333 9.42992 9.13136 0.45091152007169494 9.643661449275362 0.47209746123596713 27.2567 25.7196 19.3234 8.80307904826488 29.514435090965154 9.186057562423375 14.7631;18.1872;12.8863 9.42992;10.0176;9.13136 25.7196;36.7271;19.3234 3 0 3 24426;312495;24296 GSTP1_8762;CYP26B1_8418;CYP1A1_8415 15.278866666666667 14.7631 2.6878237746052673 9.526293333333333 9.42992 0.45091152007169494 27.2567 25.7196 8.80307904826488 14.7631;18.1872;12.8863 9.42992;10.0176;9.13136 25.7196;36.7271;19.3234 0 0 Exp 4,3(1) 4.851920356787897 21.10573410987854 2.090334892272949 15.48720932006836 7.354837602997079 3.5281898975372314 12.237307738253511 18.32042559507982 9.016038913844946 10.03654775282172 17.295078285901972 37.218321714098025 UP 1.0 0.0 0.0 GO:0030154 4 cell differentiation 405 432 28 25 14 16 10 10 58 422 2057 0.37937 0.74091 0.74366 2.31 360243;25682;362282;259241;81687;362376;64191;24296;113902;24232 top2a;ppard;pck1;nr1d2;mmp9;herc6;dhcr7;cyp1a1;ces1d;c3 TOP2A_10059;PPARD_9536;PCK1_9439;NR1D2_9358;MMP9_32531;HERC6_8794;DHCR7_8466;CYP1A1_8415;CES1D_32914;C3_8175 192.73307 90.24785 11.0684 244.80744075037632 197.83716221422617 251.91626869338995 107.697696 32.229 3.35457 159.69365315120461 102.6860727254377 161.662196806732 495.44357999999994 209.84000000000003 17.0564 631.4675270025422 549.3656149677475 690.872878564317 86.3883;94.1074;529.244;29.1728;728.316;39.6865;161.702;12.8863;11.0684;234.759 26.6888;37.7692;356.883;3.35457;443.137;15.7729;50.9087;9.13136;4.18343;129.148 262.273;148.485;1021.06;114.038;2039.06;157.407;481.517;19.3234;17.0564;694.216 3 7 3 362282;259241;24296 PCK1_9439;NR1D2_9358;CYP1A1_8415 190.4343666666667 29.1728 293.53072794881854 123.12297666666666 9.13136 202.4627230066721 384.8071333333333 114.038 553.0424907902225 529.244;29.1728;12.8863 356.883;3.35457;9.13136 1021.06;114.038;19.3234 7 360243;25682;81687;362376;64191;113902;24232 TOP2A_10059;PPARD_9536;MMP9_32531;HERC6_8794;DHCR7_8466;CES1D_32914;C3_8175 193.71822857142857 94.1074 247.3300510948526 101.08686142857144 37.7692 156.26714173139024 542.8592 262.273 698.1630884633953 86.3883;94.1074;728.316;39.6865;161.702;11.0684;234.759 26.6888;37.7692;443.137;15.7729;50.9087;4.18343;129.148 262.273;148.485;2039.06;157.407;481.517;17.0564;694.216 0 Exp 4,5(0.5);Exp 5,2(0.2);Linear,2(0.2);Poly 2,1(0.1) 2.255357233778699 31.975508093833923 1.5467612743377686 15.48720932006836 4.322972242491644 1.865848422050476 40.99984621812982 344.46629378187015 8.718544321176509 206.6768476788235 104.05595186266538 886.8312081373347 DOWN 0.3 0.7 0.0 GO:0009644 7 response to high light intensity 2 2 1 1 1 1 1 1 67 1 2478 0.9993 0.052694 0.052694 50.0 81687 mmp9 MMP9_32531 728.316 728.316 728.316 728.316 443.137 443.137 443.137 443.13699999999994 2039.06 2039.06 2039.06 2039.06 0.0 728.316 0.0 728.316 728.316 443.137 2039.06 0 1 0 1 81687 MMP9_32531 728.316 728.316 443.137 443.137 2039.06 2039.06 728.316 443.137 2039.06 0 Linear,1(1) 2.05134654045105 2.05134654045105 2.05134654045105 2.05134654045105 0.0 2.05134654045105 728.316 728.316 443.137 443.137 2039.06 2039.06 DOWN 0.0 1.0 0.0 GO:2000697 7 negative regulation of epithelial cell differentiation involved in kidney development 2 2 1 1 1 1 1 1 67 1 2478 0.9993 0.052694 0.052694 50.0 81687 mmp9 MMP9_32531 728.316 728.316 728.316 728.316 443.137 443.137 443.137 443.13699999999994 2039.06 2039.06 2039.06 2039.06 0.0 728.316 0.0 728.316 728.316 443.137 2039.06 0 1 0 1 81687 MMP9_32531 728.316 728.316 443.137 443.137 2039.06 2039.06 728.316 443.137 2039.06 0 Linear,1(1) 2.05134654045105 2.05134654045105 2.05134654045105 2.05134654045105 0.0 2.05134654045105 728.316 728.316 443.137 443.137 2039.06 2039.06 DOWN 0.0 1.0 0.0 GO:0034284 6 response to monosaccharide 105 109 9 9 6 6 5 5 63 104 2375 0.93187 0.16339 0.21244 4.59 116669;25682;362282;24426;25283 vwf;ppard;pck1;gstp1;gclc VWF_32396;PPARD_9536;PCK1_9439;GSTP1_8762;GCLC_8699 157.89818 94.1074 14.7631 213.45153892205136 90.8351685733924 122.201713860676 89.622872 37.7692 4.11644 150.27460845824726 37.98380738964411 80.76450048655424 337.31032 148.485 25.7196 407.1262754114649 236.83916495341379 251.85426029064405 19.6764;94.1074;529.244;14.7631;131.7 4.11644;37.7692;356.883;9.42992;39.9158 94.078;148.485;1021.06;25.7196;397.209 2 3 2 362282;24426 PCK1_9439;GSTP1_8762 272.00355 272.00355 363.7929331809581 183.15645999999998 183.15645999999998 245.686429012152 523.3897999999999 523.3897999999999 703.8119464289307 529.244;14.7631 356.883;9.42992 1021.06;25.7196 3 116669;25682;25283 VWF_32396;PPARD_9536;GCLC_8699 81.82793333333332 94.1074 57.012373353977594 27.26714666666666 37.7692 20.07780832821485 213.25733333333335 148.485 161.61278465620632 19.6764;94.1074;131.7 4.11644;37.7692;39.9158 94.078;148.485;397.209 0 Exp 4,1(0.2);Exp 5,1(0.2);Hill,2(0.4);Linear,1(0.2) 2.146077105252512 11.144479274749756 1.611412525177002 3.5281898975372314 0.7478478424632653 1.9746891260147095 -29.20034316520639 344.9967031652064 -42.098630003483834 221.34437400348384 -19.551594680563994 694.172234680564 DOWN 0.4 0.6 0.0 GO:0009725 4 response to hormone 388 419 29 28 18 21 15 15 53 404 2075 0.91942 0.13695 0.24349 3.58 360243;288583;25154;362282;24314;81687;24426;25283;25315;114494;24232;25612;29221;24646;170913 top2a;plod3;pgr;pck1;nqo1;mmp9;gstp1;gclc;ephx1;ccna2;c3;asns;arg1;abcb1b;abcb1a TOP2A_10059;PLOD3_9507;PGR_32824;PCK1_9439;NQO1_33055;MMP9_32531;GSTP1_8762;GCLC_8699;EPHX1_8567;CCNA2_8221;C3_8175;ASNS_8091;ARG1_33267;ABCB1B_7939;ABCB1A_7938 276.7045933333333 191.145 14.384 300.34491188704664 220.57283722807549 274.3901413981971 163.64201333333332 113.564 4.89199 198.2513209976616 122.46698510940142 171.2519739757738 804.3196066666667 510.267 25.7196 821.1661064287397 719.4444282637256 848.5196406662435 86.3883;882.629;283.618;529.244;25.6813;728.316;14.7631;131.7;39.2381;14.384;234.759;191.145;760.927;20.7941;206.982 26.6888;625.677;138.711;356.883;7.73944;443.137;9.42992;39.9158;18.9587;4.89199;129.148;113.564;413.607;8.25355;118.025 262.273;1106.02;1554.21;1021.06;86.1211;2039.06;25.7196;397.209;81.6965;58.2504;694.216;510.267;2639.93;57.2115;1531.55 4 11 4 362282;24314;24426;25315 PCK1_9439;NQO1_33055;GSTP1_8762;EPHX1_8567 152.231625 32.4597 251.5408831703424 98.252765 14.19431 172.49087608414644 303.6493 83.9088 479.06318088524256 529.244;25.6813;14.7631;39.2381 356.883;7.73944;9.42992;18.9587 1021.06;86.1211;25.7196;81.6965 11 360243;288583;25154;81687;25283;114494;24232;25612;29221;24646;170913 TOP2A_10059;PLOD3_9507;PGR_32824;MMP9_32531;GCLC_8699;CCNA2_8221;C3_8175;ASNS_8091;ARG1_33267;ABCB1B_7939;ABCB1A_7938 321.9674909090909 206.982 314.4153891562004 187.4199218181818 118.025 209.2053076392125 986.3815363636364 694.216 859.3365588881601 86.3883;882.629;283.618;728.316;131.7;14.384;234.759;191.145;760.927;20.7941;206.982 26.6888;625.677;138.711;443.137;39.9158;4.89199;129.148;113.564;413.607;8.25355;118.025 262.273;1106.02;1554.21;2039.06;397.209;58.2504;694.216;510.267;2639.93;57.2115;1531.55 0 Exp 2,1(0.07);Exp 4,4(0.27);Hill,3(0.2);Linear,2(0.14);Poly 2,5(0.34) 2.0355636040205902 33.1748811006546 1.513624906539917 6.191005229949951 1.2053283527958158 1.8874764442443848 124.70909666406229 428.70009000260427 63.31300222722497 263.97102443944175 388.7522197899832 1219.8869935433502 DOWN 0.26666666666666666 0.7333333333333333 0.0 GO:0003002 4 regionalization 36 40 2 2 2 2 2 2 66 38 2441 0.91077 0.28964 0.28964 5.0 312495;24232 cyp26b1;c3 CYP26B1_8418;C3_8175 126.47309999999999 126.47309999999999 18.1872 153.13938839377673 77.56347940379402 136.62858523709585 69.58279999999999 69.58279999999999 10.0176 84.2379136854659 42.678915627822946 75.15575901723736 365.47155 365.47155 36.7271 464.9148597448839 216.9871552393857 414.78982127910655 1.0 234.759 18.1872;234.759 10.0176;129.148 36.7271;694.216 1 1 1 312495 CYP26B1_8418 18.1872 18.1872 10.0176 10.0176 36.7271 36.7271 18.1872 10.0176 36.7271 1 24232 C3_8175 234.759 234.759 129.148 129.148 694.216 694.216 234.759 129.148 694.216 0 Exp 4,1(0.5);Poly 2,1(0.5) 1.7981237615261105 3.6370961666107178 1.5467612743377686 2.090334892272949 0.38436459131607176 1.8185480833053589 -85.76726399999997 338.713464 -47.164991999999984 186.33059199999997 -278.86757199999994 1009.8106720000001 CONFLICT 0.5 0.5 0.0 GO:0042176 6 regulation of protein catabolic process 106 112 5 5 5 3 3 3 65 109 2370 0.6497 0.58256 1.0 2.68 25283;24854;29657 gclc;clu;arntl GCLC_8699;CLU_32773;ARNTL_8086 363.42080000000004 131.7 22.9134 498.54033511975734 350.78944256032656 452.8963161591866 286.6037666666667 39.9158 11.4115 452.18619753113137 255.9073286943209 426.5933654528154 506.1394 397.209 50.1592 519.089472455645 558.6629510680177 412.5007321319833 131.7;935.649;22.9134 39.9158;808.484;11.4115 397.209;1071.05;50.1592 0 3 0 3 25283;24854;29657 GCLC_8699;CLU_32773;ARNTL_8086 363.42080000000004 131.7 498.54033511975734 286.6037666666667 39.9158 452.18619753113137 506.1394 397.209 519.089472455645 131.7;935.649;22.9134 39.9158;808.484;11.4115 397.209;1071.05;50.1592 0 Exp 4,1(0.34);Hill,1(0.34);Poly 2,1(0.34) 2.1946977823051306 6.972527503967285 1.5548590421676636 3.442979335784912 0.9913905791512687 1.9746891260147095 -200.73069749922513 927.5722974992253 -225.09308615546007 798.3006194887935 -81.26563544530438 1093.5444354453043 DOWN 0.0 1.0 0.0 GO:0060284 6 regulation of cell development 252 266 16 14 10 10 9 9 59 257 2222 0.83413 0.2755 0.42122 3.38 684352;24832;25671;338475;361921;84032;29397;29657;170913 twf2;thy1;smad1;nrep;ect2;col3a1;ccl11;arntl;abcb1a TWF2_10109;THY1_33010;SMAD1_32578;NREP_9364;ECT2_8523;COL3A1_8354;CCL11_33230;ARNTL_8086;ABCB1A_7938 184.5477666666673 61.543 5.72311E-12 311.99091178538316 222.9092852843813 343.2799358982459 102.9938455555562 25.6719 5.72311E-12 175.94509305565907 124.70775752990008 193.27341385296174 654.3432000000007 148.788 5.72313E-12 856.8168785695206 791.7047333502346 906.0119869373347 138.399;5.72311E-12;21.9973;61.543;10.0162;212.603;986.476;22.9134;206.982 90.7363;5.72311E-12;5.02186;25.6719;3.29405;119.81;552.974;11.4115;118.025 299.165;5.72313E-12;80.1461;148.788;37.7305;1510.69;2230.86;50.1592;1531.55 1 8 1 29397 CCL11_33230 986.476 986.476 552.974 552.974 2230.86 2230.86 986.476 552.974 2230.86 8 684352;24832;25671;338475;361921;84032;29657;170913 TWF2_10109;THY1_33010;SMAD1_32578;NREP_9364;ECT2_8523;COL3A1_8354;ARNTL_8086;ABCB1A_7938 84.30673750000071 42.2282 88.82698226579724 46.74632625000072 18.5417 53.26617707975142 457.2786000000008 114.46705 663.0018782504546 138.399;5.72311E-12;21.9973;61.543;10.0162;212.603;22.9134;206.982 90.7363;5.72311E-12;5.02186;25.6719;3.29405;119.81;11.4115;118.025 299.165;5.72313E-12;80.1461;148.788;37.7305;1510.69;50.1592;1531.55 0 Exp 4,4(0.45);Hill,1(0.12);Poly 2,3(0.34);Power,1(0.12) 1.913326503519369 17.69820535182953 1.6129854917526245 3.442979335784912 0.5665798730046141 1.7946586608886719 -19.28629569978304 388.3818290331176 -11.956948574141066 217.94463968525343 94.55617266791398 1214.1302273320875 DOWN 0.1111111111111111 0.8888888888888888 0.0 GO:0034764 6 positive regulation of transmembrane transport 60 63 8 8 5 7 5 5 63 58 2421 0.99406 0.024834 0.024834 7.94 24832;245920;686019;24232;170913 thy1;cxcl10;casq1;c3;abcb1a THY1_33010;CXCL10_8408;CASQ1_32992;C3_8175;ABCB1A_7938 251.98580000000115 206.982 5.72311E-12 250.93843556776886 184.25229900998818 160.46098314744026 143.71546000000114 118.025 5.72311E-12 138.8767285070022 109.09540249029698 88.4068935673832 893.3678000000011 694.216 5.72313E-12 827.9365048572249 741.6521215491307 734.9642480332525 2.5 220.8705 5.72311E-12;670.528;147.66;234.759;206.982 5.72311E-12;374.802;96.6023;129.148;118.025 5.72313E-12;1955.3;285.773;694.216;1531.55 0 5 0 5 24832;245920;686019;24232;170913 THY1_33010;CXCL10_8408;CASQ1_32992;C3_8175;ABCB1A_7938 251.98580000000115 206.982 250.93843556776886 143.71546000000114 118.025 138.8767285070022 893.3678000000011 694.216 827.9365048572249 5.72311E-12;670.528;147.66;234.759;206.982 5.72311E-12;374.802;96.6023;129.148;118.025 5.72313E-12;1955.3;285.773;694.216;1531.55 0 Exp 2,1(0.2);Hill,1(0.2);Poly 2,3(0.6) 1.8796959874122086 9.478313207626343 1.5467612743377686 2.327066659927368 0.2787087390353687 1.863204002380371 32.02856316198415 471.94303683801814 21.98464026970072 265.4462797303015 167.64945608158007 1619.0861439184223 DOWN 0.0 1.0 0.0 GO:0030855 5 epithelial cell differentiation 87 96 5 5 3 3 3 3 65 93 2386 0.74732 0.47682 0.74139 3.12 362282;24296;113902 pck1;cyp1a1;ces1d PCK1_9439;CYP1A1_8415;CES1D_32914 184.3995666666667 12.8863 11.0684 298.6454228526587 112.63287550367765 250.42266649830225 123.39926333333334 9.13136 4.18343 202.21798131890552 75.3110299936041 169.26956665641356 352.4799333333333 19.3234 17.0564 579.0084317004834 213.1694624240486 485.6165677380529 529.244;12.8863;11.0684 356.883;9.13136;4.18343 1021.06;19.3234;17.0564 2 1 2 362282;24296 PCK1_9439;CYP1A1_8415 271.06515 271.06515 365.1200311878889 183.00718 183.00718 245.897542812743 520.1917 520.1917 708.3347428227561 529.244;12.8863 356.883;9.13136 1021.06;19.3234 1 113902 CES1D_32914 11.0684 11.0684 4.18343 4.18343 17.0564 17.0564 11.0684 4.18343 17.0564 0 Exp 4,1(0.34);Exp 5,1(0.34);Linear,1(0.34) 3.437054120949638 18.725590586662292 1.611412525177002 15.48720932006836 8.00670809995257 1.6269687414169312 -153.54954327474837 522.3486766080816 -105.43192432759423 352.2304509942609 -302.7297875211275 1007.6896541877941 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0006928 3 movement of cell or subcellular component 248 268 13 13 7 7 4 4 64 264 2215 0.14113 0.93892 0.3127 1.49 25682;293502;245920;29397 ppard;kif22;cxcl10;ccl11 PPARD_9536;KIF22_8963;CXCL10_8408;CCL11_33230 442.105275 382.3177 17.3097 465.4998134899546 328.5705308545885 483.23767895677514 242.166585 206.28560000000002 3.12114 266.529809653186 177.94184186168815 275.4673369603921 1106.319275 1051.8925 90.6321 1145.1967879552853 786.3204523271102 1120.4551509710761 94.1074;17.3097;670.528;986.476 37.7692;3.12114;374.802;552.974 148.485;90.6321;1955.3;2230.86 1 3 1 29397 CCL11_33230 986.476 986.476 552.974 552.974 2230.86 2230.86 986.476 552.974 2230.86 3 25682;293502;245920 PPARD_9536;KIF22_8963;CXCL10_8408 260.6483666666667 94.1074 357.0370527654285 138.56411333333332 37.7692 205.3201800554211 731.4723666666667 148.485 1060.2604852545921 94.1074;17.3097;670.528 37.7692;3.12114;374.802 148.485;90.6321;1955.3 0 Exp 2,1(0.25);Exp 5,1(0.25);Hill,1(0.25);Power,1(0.25) 1.9077609060868423 7.634072184562683 1.8538048267364502 1.9814788103103638 0.06219476911268378 1.8993942737579346 -14.084542220155413 898.2950922201554 -19.032628460122282 503.3657984601223 -15.973577196179576 2228.6121271961797 DOWN 0.25 0.75 0.0 GO:0010628 7 positive regulation of gene expression 455 488 30 29 20 18 14 14 54 474 2005 0.68551 0.42977 0.75508 2.87 688621;360243;25671;25682;25154;362282;259241;316351;312495;24854;306575;114494;24232;29657 tslp;top2a;smad1;ppard;pgr;pck1;nr1d2;npas2;cyp26b1;clu;ckap2;ccna2;c3;arntl TSLP_32811;TOP2A_10059;SMAD1_32578;PPARD_9536;PGR_32824;PCK1_9439;NR1D2_9358;NPAS2_9350;CYP26B1_8418;CLU_32773;CKAP2_8324;CCNA2_8221;C3_8175;ARNTL_8086 190.6015571428571 59.31345 14.384 266.2395568179493 158.36291444217775 248.7207867424814 128.79859428571427 20.97855 3.35457 223.10908595529094 107.37856714718079 211.71408662466953 412.23695714285714 131.2615 36.7271 492.0487436503541 316.8607602919536 411.43228954870557 344.675;86.3883;21.9973;94.1074;283.618;529.244;29.1728;21.0878;18.1872;935.649;32.2386;14.384;234.759;22.9134 244.2;26.6888;5.02186;37.7692;138.711;356.883;3.35457;11.3305;10.0176;808.484;15.2683;4.89199;129.148;11.4115 560.435;262.273;80.1461;148.485;1554.21;1021.06;114.038;43.5624;36.7271;1071.05;76.7052;58.2504;694.216;50.1592 3 11 3 362282;259241;312495 PCK1_9439;NR1D2_9358;CYP26B1_8418 192.20133333333334 29.1728 291.93918924524905 123.41838999999999 10.0176 202.21372872293884 390.60836666666665 114.038 547.3538072345923 529.244;29.1728;18.1872 356.883;3.35457;10.0176 1021.06;114.038;36.7271 11 688621;360243;25671;25682;25154;316351;24854;306575;114494;24232;29657 TSLP_32811;TOP2A_10059;SMAD1_32578;PPARD_9536;PGR_32824;NPAS2_9350;CLU_32773;CKAP2_8324;CCNA2_8221;C3_8175;ARNTL_8086 190.16525454545453 86.3883 274.0472165055846 130.26592272727274 26.6888 237.74320758386014 418.13566363636363 148.485 504.6263022450342 344.675;86.3883;21.9973;94.1074;283.618;21.0878;935.649;32.2386;14.384;234.759;22.9134 244.2;26.6888;5.02186;37.7692;138.711;11.3305;808.484;15.2683;4.89199;129.148;11.4115 560.435;262.273;80.1461;148.485;1554.21;43.5624;1071.05;76.7052;58.2504;694.216;50.1592 0 Exp 2,1(0.08);Exp 4,8(0.58);Exp 5,1(0.08);Linear,1(0.08);Poly 2,3(0.22) 1.937540500976371 28.017101168632507 1.5405861139297485 3.442979335784912 0.5821758716485379 1.8160573244094849 51.13674852415508 330.06636576155915 11.926907952774812 245.67028061865386 154.48606285635134 669.987851429363 DOWN 0.21428571428571427 0.7857142857142857 0.0 GO:1901214 6 regulation of neuron death 149 157 8 8 3 6 3 3 65 154 2325 0.38698 0.8017 0.797 1.91 24314;25283;24854 nqo1;gclc;clu NQO1_33055;GCLC_8699;CLU_32773 364.3434333333333 131.7 25.6813 497.596753471788 251.5314733097166 419.4413514445172 285.3797466666667 39.9158 7.73944 453.307152411343 179.79170973076924 382.16888408009163 518.1266999999999 397.209 86.1211 503.47497668083764 416.3141804757085 432.4035763178127 25.6813;131.7;935.649 7.73944;39.9158;808.484 86.1211;397.209;1071.05 1 2 1 24314 NQO1_33055 25.6813 25.6813 7.73944 7.73944 86.1211 86.1211 25.6813 7.73944 86.1211 2 25283;24854 GCLC_8699;CLU_32773 533.6745 533.6745 568.4777896281438 424.1999 424.1999 543.4597860243388 734.1295 734.1295 476.4775405415244 131.7;935.649 39.9158;808.484 397.209;1071.05 0 Hill,2(0.67);Poly 2,1(0.34) 1.882499991592422 5.702325344085693 1.5548590421676636 2.1727771759033203 0.3155204681186963 1.9746891260147095 -198.7403010137151 927.4271676803818 -227.5855860150657 798.3450793483989 -51.60887010116744 1087.8622701011675 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0051276 6 chromosome organization 85 90 6 6 4 3 3 3 65 87 2392 0.78226 0.43423 0.73251 3.33 360243;316273;293502 top2a;mcm3;kif22 TOP2A_10059;MCM3_9207;KIF22_8963 100.32366666666667 86.3883 17.3097 90.7873513757469 64.95431930573805 68.85329142571582 48.74098 26.6888 3.12114 59.778636381479956 24.939396747700393 41.13236764621718 283.2733666666667 262.273 90.6321 203.95394151181125 204.63352929259747 158.7024880911292 86.3883;197.273;17.3097 26.6888;116.413;3.12114 262.273;496.915;90.6321 0 3 0 3 360243;316273;293502 TOP2A_10059;MCM3_9207;KIF22_8963 100.32366666666667 86.3883 90.7873513757469 48.74098 26.6888 59.778636381479956 283.2733666666667 262.273 203.95394151181125 86.3883;197.273;17.3097 26.6888;116.413;3.12114 262.273;496.915;90.6321 0 Exp 4,1(0.34);Hill,1(0.34);Poly 2,1(0.34) 1.7904703911807567 5.394511699676514 1.57428777217865 1.9603345394134521 0.20028713468665332 1.8598893880844116 -2.4118927747025225 203.05922610803586 -18.90491514100698 116.38687514100697 52.47775511977295 514.0689782135604 DOWN 0.0 1.0 0.0 GO:1901360 4 organic cyclic compound metabolic process 507 567 32 32 22 22 17 17 51 550 1929 0.76149 0.33584 0.55683 3.0 286989;360243;25682;299112;362282;300795;313108;291234;316273;293502;25315;64191;312495;24296;113902;116599;26760 ugt2b7;top2a;ppard;pole2;pck1;pclaf;mms22l;mki67;mcm3;kif22;ephx1;dhcr7;cyp26b1;cyp1a1;ces1d;blvra;akr7a3 UGT2B7_33032;TOP2A_10059;PPARD_9536;POLE2_9520;PCK1_9439;NS5ATP9_9367;MMS22L_33129;MKI67_9232;MCM3_9207;KIF22_8963;EPHX1_8567;DHCR7_8466;CYP26B1_8418;CYP1A1_8415;CES1D_32914;BLVRA_8151;AKR7A3_8015 124.21561178068225 52.7573 2.71598E-7 154.22959076099505 87.08423026551434 105.66886892098474 69.954845310094 18.9587 2.71598E-7 104.73241610910445 43.66687509852677 68.75940186896213 274.9234058983294 148.485 2.71599E-7 297.83100000424014 210.30607947990032 218.9714346802315 34.7126;86.3883;94.1074;2.71598E-7;529.244;292.216;126.653;21.9311;197.273;17.3097;39.2381;161.702;18.1872;12.8863;11.0684;415.991;52.7573 14.7729;26.6888;37.7692;2.71598E-7;356.883;147.515;85.587;6.82654;116.413;3.12114;18.9587;50.9087;10.0176;9.13136;4.18343;288.048;12.408 105.024;262.273;148.485;2.71599E-7;1021.06;658.494;240.486;76.1794;496.915;90.6321;81.6965;481.517;36.7271;19.3234;17.0564;720.942;216.887 6 11 6 286989;362282;25315;312495;24296;26760 UGT2B7_33032;PCK1_9439;EPHX1_8567;CYP26B1_8418;CYP1A1_8415;AKR7A3_8015 114.50425 36.975350000000006 203.6941966246535 70.36192666666666 13.59045 140.4108505300337 246.78633333333332 93.36025000000001 385.6446967867063 34.7126;529.244;39.2381;18.1872;12.8863;52.7573 14.7729;356.883;18.9587;10.0176;9.13136;12.408 105.024;1021.06;81.6965;36.7271;19.3234;216.887 11 360243;25682;299112;300795;313108;291234;316273;293502;64191;113902;116599 TOP2A_10059;PPARD_9536;POLE2_9520;NS5ATP9_9367;MMS22L_33129;MKI67_9232;MCM3_9207;KIF22_8963;DHCR7_8466;CES1D_32914;BLVRA_8151 129.5127182065089 94.1074 131.24676071464984 69.73280093378163 37.7692 87.7066088614943 290.27090002469083 240.486 258.5154815029741 86.3883;94.1074;2.71598E-7;292.216;126.653;21.9311;197.273;17.3097;161.702;11.0684;415.991 26.6888;37.7692;2.71598E-7;147.515;85.587;6.82654;116.413;3.12114;50.9087;4.18343;288.048 262.273;148.485;2.71599E-7;658.494;240.486;76.1794;496.915;90.6321;481.517;17.0564;720.942 0 Exp 2,2(0.12);Exp 4,7(0.42);Exp 5,2(0.12);Hill,3(0.18);Linear,1(0.06);Poly 2,2(0.12) 2.138344598332362 47.824193477630615 1.540663719177246 15.48720932006836 3.4232559976897017 1.7927976846694946 50.89951819982329 197.53170536154113 20.168214985023575 119.74147563516442 133.34353552552935 416.5032762711294 DOWN 0.35294117647058826 0.6470588235294118 0.0 GO:0002819 6 regulation of adaptive immune response 54 65 5 5 4 3 3 3 65 62 2417 0.90665 0.25013 0.25013 4.62 24232;29221;81639 c3;arg1;alox15 C3_8175;ARG1_33267;ALOX15_8036 587.5016666666667 760.927 234.759 305.4983151857521 662.9366419597989 254.53179703357205 321.2676666666667 413.607 129.148 166.42210448234738 362.3057939698492 138.65082668115102 1998.7386666666669 2639.93 694.216 1129.8040032613321 2277.710471733668 941.3166751964665 234.759;760.927;766.819 129.148;413.607;421.048 694.216;2639.93;2662.07 0 3 0 3 24232;29221;81639 C3_8175;ARG1_33267;ALOX15_8036 587.5016666666667 760.927 305.4983151857521 321.2676666666667 413.607 166.42210448234738 1998.7386666666669 2639.93 1129.8040032613321 234.759;760.927;766.819 129.148;413.607;421.048 694.216;2639.93;2662.07 0 Exp 2,2(0.67);Poly 2,1(0.34) 1.5207265593417565 4.562531113624573 1.5021449327468872 1.5467612743377686 0.02316760168164929 1.513624906539917 241.79777902810292 933.2055543052304 132.94332689557163 509.5920064377617 720.2450816543499 3277.2322516789836 DOWN 0.0 1.0 0.0 GO:0042573 8 retinoic acid metabolic process 6 6 2 2 2 2 2 2 66 4 2475 0.99966 0.0098306 0.0098306 33.33 312495;24296 cyp26b1;cyp1a1 CYP26B1_8418;CYP1A1_8415 15.536750000000001 15.536750000000001 12.8863 3.7483023363917627 16.365387727179904 3.5604057969827467 9.574480000000001 9.574480000000001 9.13136 0.6266663137587598 9.713017210537064 0.5952525106147942 28.02525 28.02525 19.3234 12.306274287736318 30.745799795793342 11.689379986219015 0.0 12.8863 0.0 12.8863 18.1872;12.8863 10.0176;9.13136 36.7271;19.3234 2 0 2 312495;24296 CYP26B1_8418;CYP1A1_8415 15.536750000000001 15.536750000000001 3.7483023363917627 9.574480000000001 9.574480000000001 0.6266663137587598 28.02525 28.02525 12.306274287736318 18.1872;12.8863 10.0176;9.13136 36.7271;19.3234 0 0 Exp 4,2(1) 5.6897674843242685 17.57754421234131 2.090334892272949 15.48720932006836 9.473020754598783 8.788772106170654 10.341868000000002 20.731632 8.705964800000002 10.4429952 10.969624000000003 45.080875999999996 UP 1.0 0.0 0.0 GO:0001568 4 blood vessel development 38 41 3 3 2 3 2 2 66 39 2440 0.9055 0.29965 0.29965 4.88 64191;84032 dhcr7;col3a1 DHCR7_8466;COL3A1_8354 187.1525 187.1525 161.702 35.99244226917652 172.75111518901508 29.675850982774914 85.35935 85.35935 50.9087 48.72057646256865 65.86515272927616 40.17022674052518 996.1035 996.1035 481.517 727.7352073141027 704.9202931852857 600.0193431071191 161.702;212.603 50.9087;119.81 481.517;1510.69 0 2 0 2 64191;84032 DHCR7_8466;COL3A1_8354 187.1525 187.1525 35.99244226917652 85.35935 85.35935 48.72057646256865 996.1035 996.1035 727.7352073141027 161.702;212.603 50.9087;119.81 481.517;1510.69 0 Exp 4,1(0.5);Poly 2,1(0.5) 1.7005165847528778 3.405783176422119 1.6129854917526245 1.7927976846694946 0.12714642095154255 1.7028915882110596 137.26952 237.03548 17.836076000000034 152.88262399999996 -12.486039999999889 2004.6930399999997 DOWN 0.0 1.0 0.0 GO:2000490 7 negative regulation of hepatic stellate cell activation 1 1 1 1 1 1 1 1 67 0 2479 1.0 0.026698 0.026698 100.0 25283 gclc GCLC_8699 131.7 131.7 131.7 131.7 39.9158 39.9158 39.9158 39.9158 397.209 397.209 397.209 397.209 0.0 131.7 0.0 131.7 131.7 39.9158 397.209 0 1 0 1 25283 GCLC_8699 131.7 131.7 39.9158 39.9158 397.209 397.209 131.7 39.9158 397.209 0 Hill,1(1) 1.9746891260147095 1.9746891260147095 1.9746891260147095 1.9746891260147095 0.0 1.9746891260147095 131.7 131.7 39.9158 39.9158 397.209 397.209 DOWN 0.0 1.0 0.0 GO:0062012 5 regulation of small molecule metabolic process 117 127 5 4 4 3 3 3 65 124 2355 0.5572 0.66893 1.0 2.36 25682;64191;113902 ppard;dhcr7;ces1d PPARD_9536;DHCR7_8466;CES1D_32914 88.95926666666666 94.1074 11.0684 75.44864359187204 126.77204998990511 61.848591499840865 30.95377666666667 37.7692 4.18343 24.096684638195217 42.153545011104384 17.96587808272934 215.68613333333334 148.485 17.0564 239.41158384475332 340.7055469816273 225.64555162070153 94.1074;161.702;11.0684 37.7692;50.9087;4.18343 148.485;481.517;17.0564 0 3 0 3 25682;64191;113902 PPARD_9536;DHCR7_8466;CES1D_32914 88.95926666666666 94.1074 75.44864359187204 30.95377666666667 37.7692 24.096684638195217 215.68613333333334 148.485 239.41158384475332 94.1074;161.702;11.0684 37.7692;50.9087;4.18343 148.485;481.517;17.0564 0 Exp 4,1(0.34);Exp 5,2(0.67) 1.781648000058621 5.358665585517883 1.6269687414169312 1.9388991594314575 0.1560691433471073 1.7927976846694946 3.5810890786581098 174.33744425467518 3.685811036285191 58.22174229704814 -55.23357773123735 486.605844397904 DOWN 0.0 1.0 0.0 GO:0048585 5 negative regulation of response to stimulus 377 396 30 29 20 21 16 16 52 380 2099 0.97281 0.052681 0.087124 4.04 24832;295703;25682;259241;81687;24426;156275;25283;24367;312495;84032;24854;246142;29657;29221;81639 thy1;serping1;ppard;nr1d2;mmp9;gstp1;ggt7;gclc;fgg;cyp26b1;col3a1;clu;bmf;arntl;arg1;alox15 THY1_33010;SERPING1_32597;PPARD_9536;NR1D2_9358;MMP9_32531;GSTP1_8762;GGT7_33026;GCLC_8699;FGG_8639;CYP26B1_8418;COL3A1_8354;CLU_32773;BMF_8152;ARNTL_8086;ARG1_33267;ALOX15_8036 251.18930000000034 101.8582 5.72311E-12 333.2483406121524 270.57280691789816 334.52041645738814 153.96999937500036 33.5514 5.72311E-12 237.33756139053642 161.93004827793308 231.36747702375638 716.1773625000003 184.28500000000003 5.72313E-12 959.9116296795836 765.0652997632308 985.7762594298076 5.72311E-12;32.3997;94.1074;29.1728;728.316;14.7631;109.609;131.7;42.4612;18.1872;212.603;935.649;119.401;22.9134;760.927;766.819 5.72311E-12;13.7308;37.7692;3.35457;443.137;9.42992;29.3336;39.9158;20.6424;10.0176;119.81;808.484;81.8286;11.4115;413.607;421.048 5.72313E-12;99.4885;148.485;114.038;2039.06;25.7196;346.073;397.209;98.0534;36.7271;1510.69;1071.05;220.085;50.1592;2639.93;2662.07 3 13 3 259241;24426;312495 NR1D2_9358;GSTP1_8762;CYP26B1_8418 20.7077 18.1872 7.528250375087166 7.600696666666667 9.42992 3.688974884386356 58.82823333333334 36.7271 48.12878572749714 29.1728;14.7631;18.1872 3.35457;9.42992;10.0176 114.038;25.7196;36.7271 13 24832;295703;25682;81687;156275;25283;24367;84032;24854;246142;29657;29221;81639 THY1_33010;SERPING1_32597;PPARD_9536;MMP9_32531;GGT7_33026;GCLC_8699;FGG_8639;COL3A1_8354;CLU_32773;BMF_8152;ARNTL_8086;ARG1_33267;ALOX15_8036 304.37736153846197 119.401 349.94780400265256 187.7475307692312 39.9158 252.6205412195311 867.8733153846158 346.073 1009.1806516283208 5.72311E-12;32.3997;94.1074;728.316;109.609;131.7;42.4612;212.603;935.649;119.401;22.9134;760.927;766.819 5.72311E-12;13.7308;37.7692;443.137;29.3336;39.9158;20.6424;119.81;808.484;81.8286;11.4115;413.607;421.048 5.72313E-12;99.4885;148.485;2039.06;346.073;397.209;98.0534;1510.69;1071.05;220.085;50.1592;2639.93;2662.07 0 Exp 2,2(0.13);Exp 4,7(0.44);Exp 5,1(0.07);Hill,2(0.13);Linear,1(0.07);Poly 2,3(0.19) 2.007011469493829 33.3257611989975 1.5021449327468872 3.5281898975372314 0.6386009829085327 1.9348425269126892 87.89761310004567 414.48098689995504 37.67459429363751 270.26540445636317 245.82066395700434 1186.5340610429962 DOWN 0.1875 0.8125 0.0 GO:0010634 6 positive regulation of epithelial cell migration 44 46 5 5 3 3 2 2 66 44 2435 0.87729 0.34927 0.34927 4.35 81687;81919 mmp9;fut1 MMP9_32531;FUT1_8668 484.5885 484.5885 240.861 344.6827360232885 463.4451559190877 343.38332300018925 261.0548 261.0548 78.9726 257.50311670673034 245.25918150963886 256.5323605058316 1443.465 1443.465 847.87 842.2985266816036 1391.7971741786587 839.1231611627649 728.316;240.861 443.137;78.9726 2039.06;847.87 0 2 0 2 81687;81919 MMP9_32531;FUT1_8668 484.5885 484.5885 344.6827360232885 261.0548 261.0548 257.50311670673034 1443.465 1443.465 842.2985266816036 728.316;240.861 443.137;78.9726 2039.06;847.87 0 Exp 2,1(0.5);Linear,1(0.5) 2.369504814214842 4.788355112075806 2.05134654045105 2.737008571624756 0.4848362718450695 2.394177556037903 6.882600000000025 962.2944 -95.82631199999992 617.9359119999999 276.0988 2610.8311999999996 DOWN 0.0 1.0 0.0 GO:0034379 8 very-low-density lipoprotein particle assembly 3 3 1 1 1 1 1 1 67 2 2477 0.99793 0.078005 0.078005 33.33 113902 ces1d CES1D_32914 11.0684 11.0684 11.0684 11.0684 4.18343 4.18343 4.18343 4.18343 17.0564 17.0564 17.0564 17.0564 0.0 11.0684 0.0 11.0684 11.0684 4.18343 17.0564 0 1 0 1 113902 CES1D_32914 11.0684 11.0684 4.18343 4.18343 17.0564 17.0564 11.0684 4.18343 17.0564 0 Exp 5,1(1) 1.6269687414169312 1.6269687414169312 1.6269687414169312 1.6269687414169312 0.0 1.6269687414169312 11.0684 11.0684 4.18343 4.18343 17.0564 17.0564 DOWN 0.0 1.0 0.0 GO:0007623 3 circadian rhythm 58 63 9 9 7 5 4 4 64 59 2420 0.97517 0.085392 0.085392 6.35 259241;316351;29657;170913 nr1d2;npas2;arntl;abcb1a NR1D2_9358;NPAS2_9350;ARNTL_8086;ABCB1A_7938 70.039 26.0431 21.0878 91.36095757714743 92.72296155802127 101.9672612542737 36.030392500000005 11.371 3.35457 54.79355069278584 49.1858151063338 61.50166022926075 434.8274 82.0986 43.5624 731.8388312598523 617.8720708737864 815.4964344640429 2.5 118.0774 29.1728;21.0878;22.9134;206.982 3.35457;11.3305;11.4115;118.025 114.038;43.5624;50.1592;1531.55 1 3 1 259241 NR1D2_9358 29.1728 29.1728 3.35457 3.35457 114.038 114.038 29.1728 3.35457 114.038 3 316351;29657;170913 NPAS2_9350;ARNTL_8086;ABCB1A_7938 83.66106666666667 22.9134 106.80296181517313 46.922333333333334 11.4115 61.57672892890085 541.7572 50.1592 857.1920552836685 21.0878;22.9134;206.982 11.3305;11.4115;118.025 43.5624;50.1592;1531.55 0 Exp 4,3(0.75);Poly 2,1(0.25) 2.5717661320935687 10.597300052642822 1.8874764442443848 3.442979335784912 0.7343227965241248 2.6334221363067627 -19.494738425604467 159.57273842560448 -17.667287178930124 89.72807217893012 -282.37465463465537 1152.0294546346554 DOWN 0.25 0.75 0.0 GO:0001889 6 liver development 91 101 11 11 7 7 5 5 63 96 2383 0.94971 0.12989 0.19137 4.95 116669;25315;24296;25612;29221 vwf;ephx1;cyp1a1;asns;arg1 VWF_32396;EPHX1_8567;CYP1A1_8415;ASNS_8091;ARG1_33267 204.77456 39.2381 12.8863 319.3650161548272 198.46350322345086 308.5982799845274 111.87550000000002 18.9587 4.11644 174.53270049131424 107.94652848668194 169.36320104894432 669.05898 94.078 19.3234 1118.8500351454175 650.1354375791083 1075.725113954903 19.6764;39.2381;12.8863;191.145;760.927 4.11644;18.9587;9.13136;113.564;413.607 94.078;81.6965;19.3234;510.267;2639.93 2 3 2 25315;24296 EPHX1_8567;CYP1A1_8415 26.0622 26.0622 18.633536476471672 14.04503 14.04503 6.948978755025805 50.50995 50.50995 44.10444197362663 39.2381;12.8863 18.9587;9.13136 81.6965;19.3234 3 116669;25612;29221 VWF_32396;ASNS_8091;ARG1_33267 323.91613333333333 191.145 388.0518565669456 177.09581333333335 113.564 212.00907565796453 1081.425 510.267 1365.6524803913328 19.6764;191.145;760.927 4.11644;113.564;413.607 94.078;510.267;2639.93 0 Exp 2,1(0.2);Exp 4,2(0.4);Hill,1(0.2);Poly 2,1(0.2) 2.8293011527659786 22.94593608379364 1.513624906539917 15.48720932006836 6.096525229897851 2.0484321117401123 -75.16121921694469 484.7103392169447 -41.1091571773143 264.86015717731425 -311.65631620356737 1649.7742762035673 DOWN 0.4 0.6 0.0 GO:0033554 4 cellular response to stress 394 417 35 35 28 26 23 23 45 394 2085 0.99991 2.7365E-4 3.3836E-4 5.52 116669;360243;25682;299112;363131;362282;300795;338475;24314;313108;81687;291234;316273;293502;361921;245920;114494;246142;25612;29657;29221;81639;170913 vwf;top2a;ppard;pole2;pik3r4;pck1;pclaf;nrep;nqo1;mms22l;mmp9;mki67;mcm3;kif22;ect2;cxcl10;ccna2;bmf;asns;arntl;arg1;alox15;abcb1a VWF_32396;TOP2A_10059;PPARD_9536;POLE2_9520;PIK3R4_9484;PCK1_9439;NS5ATP9_9367;NREP_9364;NQO1_33055;MMS22L_33129;MMP9_32531;MKI67_9232;MCM3_9207;KIF22_8963;ECT2_8523;CXCL10_8408;CCNA2_8221;BMF_8152;ASNS_8091;ARNTL_8086;ARG1_33267;ALOX15_8036;ABCB1A_7938 257.3514260987651 119.401 2.71598E-7 307.02839259246133 194.3795193286734 272.43303560457986 153.87689566398254 81.8286 2.71598E-7 200.88270668819803 111.81857749288895 167.48263725519826 709.4297260987652 240.486 2.71599E-7 871.4813340816195 597.4704165920195 856.5796853161035 19.5 744.6215 19.6764;86.3883;94.1074;2.71598E-7;955.628;529.244;292.216;61.543;25.6813;126.653;728.316;21.9311;197.273;17.3097;10.0162;670.528;14.384;119.401;191.145;22.9134;760.927;766.819;206.982 4.11644;26.6888;37.7692;2.71598E-7;735.228;356.883;147.515;25.6719;7.73944;85.587;443.137;6.82654;116.413;3.12114;3.29405;374.802;4.89199;81.8286;113.564;11.4115;413.607;421.048;118.025 94.078;262.273;148.485;2.71599E-7;1288.97;1021.06;658.494;148.788;86.1211;240.486;2039.06;76.1794;496.915;90.6321;37.7305;1955.3;58.2504;220.085;510.267;50.1592;2639.93;2662.07;1531.55 2 21 2 362282;24314 PCK1_9439;NQO1_33055 277.46265 277.46265 356.0725999226071 182.31122 182.31122 246.8817788836122 553.59055 553.59055 661.1016361850914 529.244;25.6813 356.883;7.73944 1021.06;86.1211 21 116669;360243;25682;299112;363131;300795;338475;313108;81687;291234;316273;293502;361921;245920;114494;246142;25612;29657;29221;81639;170913 VWF_32396;TOP2A_10059;PPARD_9536;POLE2_9520;PIK3R4_9484;NS5ATP9_9367;NREP_9364;MMS22L_33129;MMP9_32531;MKI67_9232;MCM3_9207;KIF22_8963;ECT2_8523;CXCL10_8408;CCNA2_8221;BMF_8152;ASNS_8091;ARNTL_8086;ARG1_33267;ALOX15_8036;ABCB1A_7938 255.43607144150462 119.401 311.94453718185633 151.168864774838 81.8286 203.10875463866995 724.2715523938857 240.486 900.5082119951708 19.6764;86.3883;94.1074;2.71598E-7;955.628;292.216;61.543;126.653;728.316;21.9311;197.273;17.3097;10.0162;670.528;14.384;119.401;191.145;22.9134;760.927;766.819;206.982 4.11644;26.6888;37.7692;2.71598E-7;735.228;147.515;25.6719;85.587;443.137;6.82654;116.413;3.12114;3.29405;374.802;4.89199;81.8286;113.564;11.4115;413.607;421.048;118.025 94.078;262.273;148.485;2.71599E-7;1288.97;658.494;148.788;240.486;2039.06;76.1794;496.915;90.6321;37.7305;1955.3;58.2504;220.085;510.267;50.1592;2639.93;2662.07;1531.55 0 Exp 2,4(0.18);Exp 4,6(0.27);Exp 5,1(0.05);Hill,4(0.18);Linear,2(0.09);Poly 2,6(0.27) 1.8027503453822167 42.198094844818115 1.5018656253814697 3.442979335784912 0.40353652071543317 1.7863717079162598 131.87252915337214 382.83032304415815 71.77849350057637 235.9752978273886 353.26554341286 1065.5939087846705 DOWN 0.08695652173913043 0.9130434782608695 0.0 GO:0034765 6 regulation of ion transmembrane transport 95 99 9 8 5 7 5 5 63 94 2385 0.95366 0.12207 0.18711 5.05 24832;81687;245920;686019;170913 thy1;mmp9;cxcl10;casq1;abcb1a THY1_33010;MMP9_32531;CXCL10_8408;CASQ1_32992;ABCB1A_7938 350.69720000000115 206.982 5.72311E-12 327.77827419034196 314.165852945498 302.8460225745867 206.51326000000114 118.025 5.72311E-12 191.6182482073078 189.83618843470026 181.24075358583747 1162.3366000000012 1531.55 5.72313E-12 955.6599192614474 1066.4221267445284 917.9481520438468 3.5 699.422 5.72311E-12;728.316;670.528;147.66;206.982 5.72311E-12;443.137;374.802;96.6023;118.025 5.72313E-12;2039.06;1955.3;285.773;1531.55 0 5 0 5 24832;81687;245920;686019;170913 THY1_33010;MMP9_32531;CXCL10_8408;CASQ1_32992;ABCB1A_7938 350.69720000000115 206.982 327.77827419034196 206.51326000000114 118.025 191.6182482073078 1162.3366000000012 1531.55 955.6599192614474 5.72311E-12;728.316;670.528;147.66;206.982 5.72311E-12;443.137;374.802;96.6023;118.025 5.72313E-12;2039.06;1955.3;285.773;1531.55 0 Exp 2,1(0.2);Hill,1(0.2);Linear,1(0.2);Poly 2,2(0.4) 1.9888899944038245 9.982898473739624 1.8538048267364502 2.327066659927368 0.2014313152556257 1.8874764442443848 63.386874966230664 638.0075250337716 38.552459941381954 374.47406005862035 324.66374720650253 2000.0094527934993 DOWN 0.0 1.0 0.0 GO:0006694 6 steroid biosynthetic process 45 49 5 5 4 5 4 4 64 45 2434 0.99102 0.039983 0.039983 8.16 64191;312495;24296;113902 dhcr7;cyp26b1;cyp1a1;ces1d DHCR7_8466;CYP26B1_8418;CYP1A1_8415;CES1D_32914 50.960975000000005 15.536750000000001 11.0684 73.88909112601918 80.77529500120744 83.90463088146167 18.560272500000004 9.574480000000001 4.18343 21.717857524530935 27.644337806326977 24.169785023182826 138.655975 28.02525 17.0564 228.74286737085924 230.7389184158416 260.00068656045295 1.5 15.536750000000001 161.702;18.1872;12.8863;11.0684 50.9087;10.0176;9.13136;4.18343 481.517;36.7271;19.3234;17.0564 2 2 2 312495;24296 CYP26B1_8418;CYP1A1_8415 15.536750000000001 15.536750000000001 3.7483023363917627 9.574480000000001 9.574480000000001 0.6266663137587598 28.02525 28.02525 12.306274287736318 18.1872;12.8863 10.0176;9.13136 36.7271;19.3234 2 64191;113902 DHCR7_8466;CES1D_32914 86.3852 86.3852 106.51404003454194 27.546065000000002 27.546065000000002 33.03975526977236 249.2867 249.2867 328.4232398539726 161.702;11.0684 50.9087;4.18343 481.517;17.0564 0 Exp 4,3(0.75);Exp 5,1(0.25) 3.117273319368652 20.997310638427734 1.6269687414169312 15.48720932006836 6.827946001483229 1.941566288471222 -21.4503343034988 123.37228430349879 -2.7232278740403153 39.843772874040326 -85.51203502344205 362.8239850234421 CONFLICT 0.5 0.5 0.0 GO:0071241 5 cellular response to inorganic substance 104 113 12 11 7 8 6 6 62 107 2372 0.97099 0.078282 0.12208 5.31 24314;81687;361921;24296;114494;81639 nqo1;mmp9;ect2;cyp1a1;ccna2;alox15 NQO1_33055;MMP9_32531;ECT2_8523;CYP1A1_8415;CCNA2_8221;ALOX15_8036 259.6838 20.03265 10.0162 378.1466192730486 264.52642474615607 378.28587586814626 148.20697333333334 8.435400000000001 3.29405 220.01729041316798 151.64101883347837 222.16598780658057 817.0925666666667 72.18575 19.3234 1204.2547679682777 821.6353932579054 1184.4752398883556 4.5 747.5675 25.6813;728.316;10.0162;12.8863;14.384;766.819 7.73944;443.137;3.29405;9.13136;4.89199;421.048 86.1211;2039.06;37.7305;19.3234;58.2504;2662.07 2 4 2 24314;24296 NQO1_33055;CYP1A1_8415 19.2838 19.2838 9.047431265281876 8.435400000000001 8.435400000000001 0.9842360708691725 52.72225 52.72225 47.23310663766464 25.6813;12.8863 7.73944;9.13136 86.1211;19.3234 4 81687;361921;114494;81639 MMP9_32531;ECT2_8523;CCNA2_8221;ALOX15_8036 379.8838 371.35 424.859189350103 218.09276 212.969995 247.2709671237151 1199.277725 1048.6552 1353.5300540322587 728.316;10.0162;14.384;766.819 443.137;3.29405;4.89199;421.048 2039.06;37.7305;58.2504;2662.07 0 Exp 2,1(0.17);Exp 4,3(0.5);Hill,1(0.17);Linear,1(0.17) 2.551537476013523 24.47610855102539 1.5021449327468872 15.48720932006836 5.594905663677293 1.8435909748077393 -42.89651329130635 562.2641132913063 -27.84352472665421 324.2574713933209 -146.51193593310393 1780.6970692664372 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0055085 4 transmembrane transport 188 198 13 13 9 10 7 7 61 191 2288 0.84611 0.27443 0.36482 3.54 313089;294881;170551;89776;170945;24646;170913 slc7a13;slc7a12;slc5a6;slc22a7;chrna2;abcb1b;abcb1a SLC7A13_32952;SLC7A12_32838;SLC5A6_9881;SLC22A7_9847;CHRNA2_32401;ABCB1B_7939;ABCB1A_7938 142.333 120.077 20.7941 132.16759462582598 122.11514028626806 113.23386815411628 88.5104357142857 82.2177 8.25355 95.91731741601164 73.63169581886727 80.84280896453501 455.14221428571426 221.286 57.2115 517.9093878096065 419.8110050906302 514.0181182348122 397.931;37.9163;120.077;49.1516;163.479;20.7941;206.982 280.111;15.3983;82.2177;13.5995;101.968;8.25355;118.025 668.129;132.15;221.286;161.307;414.362;57.2115;1531.55 0 7 0 7 313089;294881;170551;89776;170945;24646;170913 SLC7A13_32952;SLC7A12_32838;SLC5A6_9881;SLC22A7_9847;CHRNA2_32401;ABCB1B_7939;ABCB1A_7938 142.333 120.077 132.16759462582598 88.5104357142857 82.2177 95.91731741601164 455.14221428571426 221.286 517.9093878096065 397.931;37.9163;120.077;49.1516;163.479;20.7941;206.982 280.111;15.3983;82.2177;13.5995;101.968;8.25355;118.025 668.129;132.15;221.286;161.307;414.362;57.2115;1531.55 0 Exp 2,1(0.15);Exp 4,1(0.15);Hill,2(0.29);Poly 2,3(0.43) 2.230792150344366 17.579651832580566 1.517665982246399 6.191005229949951 1.642046837659516 1.8974558115005493 44.42187570677093 240.24412429322905 17.45389258826657 159.56697884030487 71.46957057893502 838.8148579924934 DOWN 0.0 1.0 0.0 GO:1902653 6 secondary alcohol biosynthetic process 22 22 3 3 3 3 3 3 65 19 2460 0.99763 0.019495 0.019495 13.64 64191;312495;113902 dhcr7;cyp26b1;ces1d DHCR7_8466;CYP26B1_8418;CES1D_32914 63.65253333333334 18.1872 11.0684 84.98789774769895 93.95450701885923 88.62765058437303 21.703243333333333 10.0176 4.18343 25.460330108398704 31.23824075898264 25.79936976561704 178.4335 36.7271 17.0564 262.6622167134245 271.7807682911356 274.35743468269743 0.5 14.6278 1.5 89.9446 161.702;18.1872;11.0684 50.9087;10.0176;4.18343 481.517;36.7271;17.0564 1 2 1 312495 CYP26B1_8418 18.1872 18.1872 10.0176 10.0176 36.7271 36.7271 18.1872 10.0176 36.7271 2 64191;113902 DHCR7_8466;CES1D_32914 86.3852 86.3852 106.51404003454194 27.546065000000002 27.546065000000002 33.03975526977236 249.2867 249.2867 328.4232398539726 161.702;11.0684 50.9087;4.18343 481.517;17.0564 0 Exp 4,2(0.67);Exp 5,1(0.34) 1.826874808615361 5.510101318359375 1.6269687414169312 2.090334892272949 0.23478210397722865 1.7927976846694946 -32.52032652595567 159.8253931926223 -7.107832412478487 50.51431907914515 -118.79677898986137 475.6637789898613 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0007420 5 brain development 75 79 4 3 3 3 3 3 65 76 2403 0.84201 0.35356 0.46755 3.8 360243;24646;170913 top2a;abcb1b;abcb1a TOP2A_10059;ABCB1B_7939;ABCB1A_7938 104.72146666666667 86.3883 20.7941 94.43813994686329 92.24732733249053 92.46148823351149 50.98911666666667 26.6888 8.25355 58.78198577243571 43.987761112515805 56.308568091778014 617.0115 262.273 57.2115 798.622599030512 523.7186110408766 762.8317053289645 86.3883;20.7941;206.982 26.6888;8.25355;118.025 262.273;57.2115;1531.55 0 3 0 3 360243;24646;170913 TOP2A_10059;ABCB1B_7939;ABCB1A_7938 104.72146666666667 86.3883 94.43813994686329 50.98911666666667 26.6888 58.78198577243571 617.0115 262.273 798.622599030512 86.3883;20.7941;206.982 26.6888;8.25355;118.025 262.273;57.2115;1531.55 0 Exp 4,1(0.34);Hill,1(0.34);Poly 2,1(0.34) 2.8400389811878473 10.038816213607788 1.8874764442443848 6.191005229949951 2.4638805031627338 1.9603345394134521 -2.1453489527079057 211.58828228604125 -15.528962139397684 117.50719547273101 -286.7150461611219 1520.738046161122 DOWN 0.0 1.0 0.0 GO:2000323 8 negative regulation of glucocorticoid receptor signaling pathway 2 2 1 1 1 1 1 1 67 1 2478 0.9993 0.052694 0.052694 50.0 29657 arntl ARNTL_8086 22.9134 22.9134 22.9134 22.9134 11.4115 11.4115 11.4115 11.4115 50.1592 50.1592 50.1592 50.1592 0.0 22.9134 0.0 22.9134 22.9134 11.4115 50.1592 0 1 0 1 29657 ARNTL_8086 22.9134 22.9134 11.4115 11.4115 50.1592 50.1592 22.9134 11.4115 50.1592 0 Exp 4,1(1) 3.4429793357849126 3.442979335784912 3.442979335784912 3.442979335784912 0.0 3.442979335784912 22.9134 22.9134 11.4115 11.4115 50.1592 50.1592 DOWN 0.0 1.0 0.0 GO:0034329 6 cell junction assembly 40 41 4 4 3 2 2 2 66 39 2440 0.9055 0.29965 0.29965 4.88 24832;361921 thy1;ect2 THY1_33010;ECT2_8523 5.0081000000028615 5.0081000000028615 5.72311E-12 7.0825229417166495 6.5671290901692485 6.730600850739301 1.6470250000028615 1.6470250000028615 5.72311E-12 2.3292450925634998 2.15974636883102 2.2135076907761366 18.86525000000286 18.86525000000286 5.72313E-12 26.67949240755499 24.73803080375554 25.35382035092408 5.72311E-12;10.0162 5.72311E-12;3.29405 5.72313E-12;37.7305 0 2 0 2 24832;361921 THY1_33010;ECT2_8523 5.0081000000028615 5.0081000000028615 7.0825229417166495 1.6470250000028615 1.6470250000028615 2.3292450925634998 18.86525000000286 18.86525000000286 26.67949240755499 5.72311E-12;10.0162 5.72311E-12;3.29405 5.72313E-12;37.7305 0 Exp 4,1(0.5);Hill,1(0.5) 1.745822179258442 3.4990394115448 1.6358354091644287 1.863204002380371 0.1607738740918385 1.7495197057724 -4.807775999991526 14.823975999997248 -1.5811439999915298 4.875193999997253 -18.11063999999153 55.84113999999725 DOWN 0.0 1.0 0.0 GO:0071216 4 cellular response to biotic stimulus 97 103 12 12 9 9 8 8 60 95 2384 0.99863 0.0053618 0.0053618 7.77 116669;25682;81687;24426;245920;29221;24646;170913 vwf;ppard;mmp9;gstp1;cxcl10;arg1;abcb1b;abcb1a VWF_32396;PPARD_9536;MMP9_32531;GSTP1_8762;CXCL10_8408;ARG1_33267;ABCB1B_7939;ABCB1A_7938 314.51175 150.5447 14.7631 342.35654396229336 261.23838910521056 332.53096938217055 176.14251375 77.8971 4.11644 198.29221289780935 146.98329027682414 194.85708523066654 1061.4167625 840.0174999999999 25.7196 1090.0739391788036 922.8511773238885 1074.3754847292848 4.5 438.755 19.6764;94.1074;728.316;14.7631;670.528;760.927;20.7941;206.982 4.11644;37.7692;443.137;9.42992;374.802;413.607;8.25355;118.025 94.078;148.485;2039.06;25.7196;1955.3;2639.93;57.2115;1531.55 1 7 1 24426 GSTP1_8762 14.7631 14.7631 9.42992 9.42992 25.7196 25.7196 14.7631 9.42992 25.7196 7 116669;25682;81687;245920;29221;24646;170913 VWF_32396;PPARD_9536;MMP9_32531;CXCL10_8408;ARG1_33267;ABCB1B_7939;ABCB1A_7938 357.3329857142857 206.982 345.8735707314473 199.95859857142858 118.025 201.4427469046595 1209.3735 1531.55 1087.192206598071 19.6764;94.1074;728.316;670.528;760.927;20.7941;206.982 4.11644;37.7692;443.137;374.802;413.607;8.25355;118.025 94.078;148.485;2039.06;1955.3;2639.93;57.2115;1531.55 0 Exp 2,2(0.25);Exp 4,1(0.13);Exp 5,1(0.13);Hill,2(0.25);Linear,1(0.13);Poly 2,1(0.13) 2.359992617991833 21.055635571479797 1.513624906539917 6.191005229949951 1.5579407890178707 1.9951228499412537 77.27076885705858 551.7527311429415 38.73302072140302 313.55200677859705 306.0340615996972 1816.7994634003028 DOWN 0.125 0.875 0.0 GO:0007052 7 mitotic spindle organization 19 19 2 2 1 1 1 1 67 18 2461 0.91026 0.4031 0.4031 5.26 295661 spc25 SPC25_9925 35.8903 35.8903 35.8903 35.8903 11.5744 11.5744 11.5744 11.5744 124.006 124.006 124.006 124.006 0.0 35.8903 35.8903 11.5744 124.006 0 1 0 1 295661 SPC25_9925 35.8903 35.8903 11.5744 11.5744 124.006 124.006 35.8903 11.5744 124.006 0 Exp 4,1(1) 1.5933629274368286 1.5933629274368286 1.5933629274368286 1.5933629274368286 0.0 1.5933629274368286 35.8903 35.8903 11.5744 11.5744 124.006 124.006 DOWN 0.0 1.0 0.0 GO:0002888 8 positive regulation of myeloid leukocyte mediated immunity 20 22 3 3 2 2 2 2 66 20 2459 0.98051 0.11526 0.11526 9.09 24232;29221 c3;arg1 C3_8175;ARG1_33267 497.843 497.843 234.759 372.0569608433633 595.528773174521 345.45819074179184 271.3775 271.3775 129.148 201.14288786954415 324.18876437079234 186.7629568507003 1667.0729999999999 1667.0729999999999 694.216 1375.827563649602 2028.3047291558773 1277.4681055118795 0.5 497.843 234.759;760.927 129.148;413.607 694.216;2639.93 0 2 0 2 24232;29221 C3_8175;ARG1_33267 497.843 497.843 372.0569608433633 271.3775 271.3775 201.14288786954415 1667.0729999999999 1667.0729999999999 1375.827563649602 234.759;760.927 129.148;413.607 694.216;2639.93 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.5301033917056286 3.0603861808776855 1.513624906539917 1.5467612743377686 0.023430950373752386 1.5301930904388428 -17.801639999999907 1013.4876399999998 -7.392320000000041 550.1473200000001 -239.7267199999999 3573.8727199999994 DOWN 0.0 1.0 0.0 GO:0046685 4 response to arsenic-containing substance 19 20 4 4 3 4 3 3 65 17 2462 0.99837 0.01499 0.01499 15.0 25283;24296;24646 gclc;cyp1a1;abcb1b GCLC_8699;CYP1A1_8415;ABCB1B_7939 55.126799999999996 20.7941 12.8863 66.4321047678756 63.5450698249322 67.7385422701104 19.100236666666664 9.13136 8.25355 18.032148936331275 20.943356722878274 18.837878514473886 157.91463333333334 57.2115 19.3234 208.09906888115415 186.16004031613286 210.10307384900452 0.0 12.8863 1.0 20.7941 131.7;12.8863;20.7941 39.9158;9.13136;8.25355 397.209;19.3234;57.2115 1 2 1 24296 CYP1A1_8415 12.8863 12.8863 9.13136 9.13136 19.3234 19.3234 12.8863 9.13136 19.3234 2 25283;24646 GCLC_8699;ABCB1B_7939 76.24705 76.24705 78.4223139635971 24.084674999999997 24.084674999999997 22.388591682623765 227.21025 227.21025 240.41453783647316 131.7;20.7941 39.9158;8.25355 397.209;57.2115 0 Exp 4,1(0.34);Hill,2(0.67) 5.742191754841856 23.65290367603302 1.9746891260147095 15.48720932006836 6.913572809675974 6.191005229949951 -20.048203398310136 130.30180339831014 -1.3050607765515743 39.505534109884906 -77.57163140249051 393.40089806915717 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0014722 8 regulation of skeletal muscle contraction by calcium ion signaling 1 1 1 1 1 1 1 1 67 0 2479 1.0 0.026698 0.026698 100.0 686019 casq1 CASQ1_32992 147.66 147.66 147.66 147.66 96.6023 96.6023 96.6023 96.6023 285.773 285.773 285.773 285.773 0.0 147.66 0.0 147.66 147.66 96.6023 285.773 0 1 0 1 686019 CASQ1_32992 147.66 147.66 96.6023 96.6023 285.773 285.773 147.66 96.6023 285.773 0 Poly 2,1(1) 2.327066659927368 2.327066659927368 2.327066659927368 2.327066659927368 0.0 2.327066659927368 147.66 147.66 96.6023 96.6023 285.773 285.773 DOWN 0.0 1.0 0.0 GO:0014809 8 regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion 1 1 1 1 1 1 1 1 67 0 2479 1.0 0.026698 0.026698 100.0 686019 casq1 CASQ1_32992 147.66 147.66 147.66 147.66 96.6023 96.6023 96.6023 96.6023 285.773 285.773 285.773 285.773 0.0 147.66 0.0 147.66 147.66 96.6023 285.773 0 1 0 1 686019 CASQ1_32992 147.66 147.66 96.6023 96.6023 285.773 285.773 147.66 96.6023 285.773 0 Poly 2,1(1) 2.327066659927368 2.327066659927368 2.327066659927368 2.327066659927368 0.0 2.327066659927368 147.66 147.66 96.6023 96.6023 285.773 285.773 DOWN 0.0 1.0 0.0 GO:0001934 9 positive regulation of protein phosphorylation 270 289 20 19 13 12 9 9 59 280 2199 0.76317 0.36441 0.56296 3.11 688621;24832;81687;24367;361921;24854;29397;24232;81639 tslp;thy1;mmp9;fgg;ect2;clu;ccl11;c3;alox15 TSLP_32811;THY1_33010;MMP9_32531;FGG_8639;ECT2_8523;CLU_32773;CCL11_33230;C3_8175;ALOX15_8036 449.907933333334 344.675 5.72311E-12 406.36976843470944 441.78630807120146 401.888755834753 291.43638333333394 244.2 5.72311E-12 284.03603591323514 282.01463021683213 271.75091973174784 1043.719433333334 694.216 5.72313E-12 1022.9354705151193 1050.2491424676068 1047.195463436523 344.675;5.72311E-12;728.316;42.4612;10.0162;935.649;986.476;234.759;766.819 244.2;5.72311E-12;443.137;20.6424;3.29405;808.484;552.974;129.148;421.048 560.435;5.72313E-12;2039.06;98.0534;37.7305;1071.05;2230.86;694.216;2662.07 1 8 1 29397 CCL11_33230 986.476 986.476 552.974 552.974 2230.86 2230.86 986.476 552.974 2230.86 8 688621;24832;81687;24367;361921;24854;24232;81639 TSLP_32811;THY1_33010;MMP9_32531;FGG_8639;ECT2_8523;CLU_32773;C3_8175;ALOX15_8036 382.8369250000007 289.717 377.4345086320522 258.74418125000074 186.67399999999998 284.9710742289211 895.3268625000007 627.3254999999999 984.5746180131403 344.675;5.72311E-12;728.316;42.4612;10.0162;935.649;234.759;766.819 244.2;5.72311E-12;443.137;20.6424;3.29405;808.484;129.148;421.048 560.435;5.72313E-12;2039.06;98.0534;37.7305;1071.05;694.216;2662.07 0 Exp 2,2(0.23);Exp 4,2(0.23);Hill,1(0.12);Linear,1(0.12);Poly 2,2(0.23);Power,1(0.12) 1.8139194651069745 16.63913071155548 1.5021449327468872 2.8176381587982178 0.41339819892907403 1.6858625411987305 184.41301795599048 715.4028487106775 105.86617320335378 477.0065934633143 375.40159259678944 1712.0372740698788 DOWN 0.1111111111111111 0.8888888888888888 0.0 GO:0050678 6 regulation of epithelial cell proliferation 113 121 11 10 6 8 5 5 63 116 2363 0.89895 0.21936 0.25426 4.13 25682;25154;81919;29397;29221 ppard;pgr;fut1;ccl11;arg1 PPARD_9536;PGR_32824;FUT1_8668;CCL11_33230;ARG1_33267 473.19788 283.618 94.1074 380.74697099986497 481.2601907411947 377.927981097788 244.40676000000002 138.711 37.7692 226.42967947958587 244.24810993707607 228.97227567541142 1484.271 1554.21 148.485 1010.8368802037253 1465.0899203236088 1012.1646236867051 94.1074;283.618;240.861;986.476;760.927 37.7692;138.711;78.9726;552.974;413.607 148.485;1554.21;847.87;2230.86;2639.93 1 4 1 29397 CCL11_33230 986.476 986.476 552.974 552.974 2230.86 2230.86 986.476 552.974 2230.86 4 25682;25154;81919;29221 PPARD_9536;PGR_32824;FUT1_8668;ARG1_33267 344.87834999999995 262.2395 288.99537949816784 167.26495 108.8418 169.37573812423668 1297.62375 1201.04 1063.0805668541386 94.1074;283.618;240.861;760.927 37.7692;138.711;78.9726;413.607 148.485;1554.21;847.87;2639.93 0 Exp 2,2(0.4);Exp 5,1(0.2);Poly 2,1(0.2);Power,1(0.2) 1.8962911200546413 9.711597561836243 1.513624906539917 2.737008571624756 0.49453125250553664 1.9388991594314575 139.45844512192713 806.9373148780728 45.93239506758147 442.8811249324186 598.2334085066585 2370.3085914933413 DOWN 0.2 0.8 0.0 GO:0051649 4 establishment of localization in cell 242 254 7 7 6 3 3 3 65 251 2228 0.079797 0.97266 0.14998 1.18 363131;293502;29657 pik3r4;kif22;arntl PIK3R4_9484;KIF22_8963;ARNTL_8086 331.9503666666667 22.9134 17.3097 540.1279414209408 162.8339967529173 415.05173644332103 249.92021333333332 11.4115 3.12114 420.30931272897885 117.05792938440723 323.6409949521238 476.5871 90.6321 50.1592 703.8352051921743 271.694256705564 532.7726069211312 955.628;17.3097;22.9134 735.228;3.12114;11.4115 1288.97;90.6321;50.1592 0 3 0 3 363131;293502;29657 PIK3R4_9484;KIF22_8963;ARNTL_8086 331.9503666666667 22.9134 540.1279414209408 249.92021333333332 11.4115 420.30931272897885 476.5871 90.6321 703.8352051921743 955.628;17.3097;22.9134 735.228;3.12114;11.4115 1288.97;90.6321;50.1592 0 Exp 4,1(0.34);Hill,1(0.34);Poly 2,1(0.34) 2.1265921348266223 6.8047343492507935 1.5018656253814697 3.442979335784912 1.032979286165875 1.8598893880844116 -279.2619375907218 943.1626709240552 -225.7045485667524 725.5449752334191 -319.877412558361 1273.0516125583613 DOWN 0.0 1.0 0.0 GO:0008152 2 metabolic process 1361 1509 85 85 60 59 46 46 22 1463 1016 0.94152 0.09503 0.16971 3.05 286989;684352;315852;360243;24832;25671;291463;25682;299112;288583;363131;25154;362282;300795;24314;313108;81687;291234;316273;293502;362376;24426;156275;25283;81919;84493;24367;29243;25315;64191;312495;24296;84032;113902;297594;114494;29397;24232;116599;25612;29657;29221;81639;26760;286921;252898 ugt2b7;twf2;ttk;top2a;thy1;smad1;ppic;ppard;pole2;plod3;pik3r4;pgr;pck1;pclaf;nqo1;mms22l;mmp9;mki67;mcm3;kif22;herc6;gstp1;ggt7;gclc;fut1;fmo3;fgg;f10;ephx1;dhcr7;cyp26b1;cyp1a1;col3a1;ces1d;cdca3;ccna2;ccl11;c3;blvra;asns;arntl;arg1;alox15;akr7a3;akr1b8;acox2 UGT2B7_33032;TWF2_10109;TTK_32727;TOP2A_10059;THY1_33010;SMAD1_32578;PPIC_9541;PPARD_9536;POLE2_9520;PLOD3_9507;PIK3R4_9484;PGR_32824;PCK1_9439;NS5ATP9_9367;NQO1_33055;MMS22L_33129;MMP9_32531;MKI67_9232;MCM3_9207;KIF22_8963;HERC6_8794;GSTP1_8762;GGT7_33026;GCLC_8699;FUT1_8668;FMO3_8654;FGG_8639;F10_8585;EPHX1_8567;DHCR7_8466;CYP26B1_8418;CYP1A1_8415;COL3A1_8354;CES1D_32914;CDCA3_8260;CCNA2_8221;CCL11_33230;C3_8175;BLVRA_8151;ASNS_8091;ARNTL_8086;ARG1_33267;ALOX15_8036;AKR7A3_8015;AKR1B8_8013;ACOX2_32902 264.08153044068706 129.1765 5.72311E-12 301.90476440732044 230.61460728088582 279.1633328436587 157.81448217981747 45.41225 5.72311E-12 199.8466462299772 132.19859141754847 178.42559861523037 674.9132326146002 322.619 5.72313E-12 781.6771075026309 609.860501615327 766.1653115020591 34.7126;138.399;737.351;86.3883;5.72311E-12;21.9973;628.678;94.1074;2.71598E-7;882.629;955.628;283.618;529.244;292.216;25.6813;126.653;728.316;21.9311;197.273;17.3097;39.6865;14.7631;109.609;131.7;240.861;418.073;42.4612;104.19;39.2381;161.702;18.1872;12.8863;212.603;11.0684;56.6562;14.384;986.476;234.759;415.991;191.145;22.9134;760.927;766.819;52.7573;542.408;743.353 14.7729;90.7363;446.625;26.6888;5.72311E-12;5.02186;389.239;37.7692;2.71598E-7;625.677;735.228;138.711;356.883;147.515;7.73944;85.587;443.137;6.82654;116.413;3.12114;15.7729;9.42992;29.3336;39.9158;78.9726;293.29;20.6424;38.4229;18.9587;50.9087;10.0176;9.13136;119.81;4.18343;22.3266;4.89199;552.974;129.148;288.048;113.564;11.4115;413.607;421.048;12.408;441.021;432.537 105.024;299.165;2108.09;262.273;5.72313E-12;80.1461;1509.86;148.485;2.71599E-7;1106.02;1288.97;1554.21;1021.06;658.494;86.1211;240.486;2039.06;76.1794;496.915;90.6321;157.407;25.7196;346.073;397.209;847.87;712.184;98.0534;163.044;81.6965;481.517;36.7271;19.3234;1510.69;17.0564;150.565;58.2504;2230.86;694.216;720.942;510.267;50.1592;2639.93;2662.07;216.887;758.311;2287.79 10 36 10 286989;362282;24314;24426;25315;312495;24296;29397;26760;286921 UGT2B7_33032;PCK1_9439;NQO1_33055;GSTP1_8762;EPHX1_8567;CYP26B1_8418;CYP1A1_8415;CCL11_33230;AKR7A3_8015;AKR1B8_8013 225.63539 36.975350000000006 340.7882189258649 143.333592 13.59045 216.86253776216168 458.17296999999996 95.57255 712.5584324065704 34.7126;529.244;25.6813;14.7631;39.2381;18.1872;12.8863;986.476;52.7573;542.408 14.7729;356.883;7.73944;9.42992;18.9587;10.0176;9.13136;552.974;12.408;441.021 105.024;1021.06;86.1211;25.7196;81.6965;36.7271;19.3234;2230.86;216.887;758.311 36 684352;315852;360243;24832;25671;291463;25682;299112;288583;363131;25154;300795;313108;81687;291234;316273;293502;362376;156275;25283;81919;84493;24367;29243;64191;84032;113902;297594;114494;24232;116599;25612;29657;29221;81639;252898 TWF2_10109;TTK_32727;TOP2A_10059;THY1_33010;SMAD1_32578;PPIC_9541;PPARD_9536;POLE2_9520;PLOD3_9507;PIK3R4_9484;PGR_32824;NS5ATP9_9367;MMS22L_33129;MMP9_32531;MKI67_9232;MCM3_9207;KIF22_8963;HERC6_8794;GGT7_33026;GCLC_8699;FUT1_8668;FMO3_8654;FGG_8639;F10_8585;DHCR7_8466;COL3A1_8354;CES1D_32914;CDCA3_8260;CCNA2_8221;C3_8175;BLVRA_8151;ASNS_8091;ARNTL_8086;ARG1_33267;ALOX15_8036;ACOX2_32902 274.76101389643344 150.0505 294.5929640780033 161.8369516742112 82.2798 197.93916790380902 735.1188611186558 439.363 798.6765944747291 138.399;737.351;86.3883;5.72311E-12;21.9973;628.678;94.1074;2.71598E-7;882.629;955.628;283.618;292.216;126.653;728.316;21.9311;197.273;17.3097;39.6865;109.609;131.7;240.861;418.073;42.4612;104.19;161.702;212.603;11.0684;56.6562;14.384;234.759;415.991;191.145;22.9134;760.927;766.819;743.353 90.7363;446.625;26.6888;5.72311E-12;5.02186;389.239;37.7692;2.71598E-7;625.677;735.228;138.711;147.515;85.587;443.137;6.82654;116.413;3.12114;15.7729;29.3336;39.9158;78.9726;293.29;20.6424;38.4229;50.9087;119.81;4.18343;22.3266;4.89199;129.148;288.048;113.564;11.4115;413.607;421.048;432.537 299.165;2108.09;262.273;5.72313E-12;80.1461;1509.86;148.485;2.71599E-7;1106.02;1288.97;1554.21;658.494;240.486;2039.06;76.1794;496.915;90.6321;157.407;346.073;397.209;847.87;712.184;98.0534;163.044;481.517;1510.69;17.0564;150.565;58.2504;694.216;720.942;510.267;50.1592;2639.93;2662.07;2287.79 0 Exp 2,9(0.2);Exp 4,15(0.33);Exp 5,3(0.07);Hill,6(0.14);Linear,3(0.07);Poly 2,9(0.2);Power,1(0.03) 1.9762264413012323 104.19816243648529 1.5018656253814697 15.48720932006836 2.1277371825266522 1.7937281727790833 176.8352095287575 351.3278513526164 100.06155249557615 215.56741186405878 449.0193090636883 900.807156165512 DOWN 0.21739130434782608 0.782608695652174 0.0 GO:0044419 2 interspecies interaction between organisms 272 296 26 26 15 18 12 12 56 284 2195 0.95438 0.088773 0.1237 4.05 688621;295703;362282;304545;81687;362376;24296;245920;24854;29397;24232;29221 tslp;serping1;pck1;oasl;mmp9;herc6;cyp1a1;cxcl10;clu;ccl11;c3;arg1 TSLP_32811;SERPING1_32597;PCK1_9439;OASL_9389;MMP9_32531;HERC6_8794;CYP1A1_8415;CXCL10_8408;CLU_32773;CCL11_33230;C3_8175;ARG1_33267 446.01325833333334 436.95950000000005 12.8863 367.1975051568284 487.0731528408467 374.2655669183869 282.52648 300.5415 9.13136 254.8614712395923 308.0530145759061 254.8980649300004 1062.376575 857.6379999999999 19.3234 927.9394716333035 1176.4173932874696 986.3132781054672 344.675;32.3997;529.244;76.6126;728.316;39.6865;12.8863;670.528;935.649;986.476;234.759;760.927 244.2;13.7308;356.883;28.4477;443.137;15.7729;9.13136;374.802;808.484;552.974;129.148;413.607 560.435;99.4885;1021.06;260.389;2039.06;157.407;19.3234;1955.3;1071.05;2230.86;694.216;2639.93 3 9 3 362282;24296;29397 PCK1_9439;CYP1A1_8415;CCL11_33230 509.5354333333333 529.244 487.0939813696771 306.32945333333333 356.883 275.4232199379285 1090.4144666666668 1021.06 1107.3983315952094 529.244;12.8863;986.476 356.883;9.13136;552.974 1021.06;19.3234;2230.86 9 688621;295703;304545;81687;362376;245920;24854;24232;29221 TSLP_32811;SERPING1_32597;OASL_9389;MMP9_32531;HERC6_8794;CXCL10_8408;CLU_32773;C3_8175;ARG1_33267 424.83920000000006 344.675 352.22732813613067 274.59215555555556 244.2 264.6969584323085 1053.030611111111 694.216 936.4815581506323 344.675;32.3997;76.6126;728.316;39.6865;670.528;935.649;234.759;760.927 244.2;13.7308;28.4477;443.137;15.7729;374.802;808.484;129.148;413.607 560.435;99.4885;260.389;2039.06;157.407;1955.3;1071.05;694.216;2639.93 0 Exp 2,3(0.25);Exp 4,4(0.34);Linear,2(0.17);Poly 2,2(0.17);Power,1(0.09) 2.0829746591235394 34.67482233047485 1.513624906539917 15.48720932006836 3.971070385937023 1.7478592991828918 238.25171145424048 653.7748052124261 138.32502775428222 426.72793224571785 537.3453933356164 1587.4077566643837 DOWN 0.25 0.75 0.0 GO:0006066 4 alcohol metabolic process 93 100 6 6 6 6 6 6 62 94 2385 0.98419 0.048289 0.048289 6.0 362282;25315;64191;312495;24296;113902 pck1;ephx1;dhcr7;cyp26b1;cyp1a1;ces1d PCK1_9439;EPHX1_8567;DHCR7_8466;CYP26B1_8418;CYP1A1_8415;CES1D_32914 128.721 28.712650000000004 11.0684 204.44615048256594 95.10534464710851 127.94467192631224 75.01379833333333 14.488150000000001 4.18343 139.108173174541 41.61733723907533 79.13206963790056 276.2300666666667 59.2118 17.0564 406.2736415422869 243.9847483027417 295.50352494536327 4.0 161.702 529.244;39.2381;161.702;18.1872;12.8863;11.0684 356.883;18.9587;50.9087;10.0176;9.13136;4.18343 1021.06;81.6965;481.517;36.7271;19.3234;17.0564 4 2 4 362282;25315;312495;24296 PCK1_9439;EPHX1_8567;CYP26B1_8418;CYP1A1_8415 149.8889 28.712650000000004 253.15933166440195 98.747665 14.488150000000001 172.1474529466824 289.70175 59.2118 488.27987178187396 529.244;39.2381;18.1872;12.8863 356.883;18.9587;10.0176;9.13136 1021.06;81.6965;36.7271;19.3234 2 64191;113902 DHCR7_8466;CES1D_32914 86.3852 86.3852 106.51404003454194 27.546065000000002 27.546065000000002 33.03975526977236 249.2867 249.2867 328.4232398539726 161.702;11.0684 50.9087;4.18343 481.517;17.0564 0 Exp 4,4(0.67);Exp 5,1(0.17);Linear,1(0.17) 2.6038820434491043 24.65715527534485 1.611412525177002 15.48720932006836 5.5775946435681 1.9206148982048035 -34.86999119579349 292.3119911957935 -36.29592248725913 186.32351915392582 -48.85655178886054 601.3166851221938 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0051223 7 regulation of protein transport 189 204 11 11 6 8 5 5 63 199 2280 0.53406 0.64669 1.0 2.45 688621;25682;24367;361921;29657 tslp;ppard;fgg;ect2;arntl TSLP_32811;PPARD_9536;FGG_8639;ECT2_8523;ARNTL_8086 102.83464 42.4612 10.0162 138.93392683894027 118.1698262105263 150.86601934327348 63.463429999999995 20.6424 3.29405 101.84461142744372 75.26052147773278 110.97932659036532 178.97262 98.0534 37.7305 217.67705214843383 205.67115707692304 235.1605481717449 344.675;94.1074;42.4612;10.0162;22.9134 244.2;37.7692;20.6424;3.29405;11.4115 560.435;148.485;98.0534;37.7305;50.1592 0 5 0 5 688621;25682;24367;361921;29657 TSLP_32811;PPARD_9536;FGG_8639;ECT2_8523;ARNTL_8086 102.83464 42.4612 138.93392683894027 63.463429999999995 20.6424 101.84461142744372 178.97262 98.0534 217.67705214843383 344.675;94.1074;42.4612;10.0162;22.9134 244.2;37.7692;20.6424;3.29405;11.4115 560.435;148.485;98.0534;37.7305;50.1592 0 Exp 2,1(0.2);Exp 4,3(0.6);Exp 5,1(0.2) 2.2028621704150693 11.521214604377747 1.6358354091644287 3.442979335784912 0.7941873602415109 1.9388991594314575 -18.946316278798292 224.6155962787983 -25.807307923175877 152.73416792317587 -11.829728812300544 369.7749688123006 DOWN 0.0 1.0 0.0 GO:1990705 5 cholangiocyte proliferation 1 1 1 1 1 1 1 1 67 0 2479 1.0 0.026698 0.026698 100.0 291234 mki67 MKI67_9232 21.9311 21.9311 21.9311 21.9311 6.82654 6.82654 6.82654 6.82654 76.1794 76.1794 76.1794 76.1794 0.0 21.9311 0.0 21.9311 21.9311 6.82654 76.1794 0 1 0 1 291234 MKI67_9232 21.9311 21.9311 6.82654 6.82654 76.1794 76.1794 21.9311 6.82654 76.1794 0 Exp 4,1(1) 1.922041654586792 1.922041654586792 1.922041654586792 1.922041654586792 0.0 1.922041654586792 21.9311 21.9311 6.82654 6.82654 76.1794 76.1794 DOWN 0.0 1.0 0.0 GO:0045834 6 positive regulation of lipid metabolic process 76 82 6 5 4 4 3 3 65 79 2400 0.82638 0.37579 0.4806 3.66 25682;363131;113902 ppard;pik3r4;ces1d PPARD_9536;PIK3R4_9484;CES1D_32914 353.60126666666673 94.1074 11.0684 523.0210412748738 286.74947950060414 468.74422499290046 259.06021 37.7692 4.18343 412.71518528124966 201.28573223519936 373.1475641438088 484.8371333333334 148.485 17.0564 699.493116238218 398.6735647200967 624.8706112579498 94.1074;955.628;11.0684 37.7692;735.228;4.18343 148.485;1288.97;17.0564 0 3 0 3 25682;363131;113902 PPARD_9536;PIK3R4_9484;CES1D_32914 353.60126666666673 94.1074 523.0210412748738 259.06021 37.7692 412.71518528124966 484.8371333333334 148.485 699.493116238218 94.1074;955.628;11.0684 37.7692;735.228;4.18343 148.485;1288.97;17.0564 0 Exp 5,2(0.67);Poly 2,1(0.34) 1.6795328510102177 5.067733526229858 1.5018656253814697 1.9388991594314575 0.2250739453337951 1.6269687414169312 -238.25275771823146 945.4552910515648 -207.9709877087206 726.0914077087206 -306.71384302126046 1276.3881096879272 DOWN 0.0 1.0 0.0 GO:0006810 4 transport 570 605 28 28 20 19 14 14 54 591 1888 0.3235 0.7751 0.66469 2.31 313089;294881;170551;89776;25682;363131;24367;24854;170945;113902;29657;81639;24646;170913 slc7a13;slc7a12;slc5a6;slc22a7;ppard;pik3r4;fgg;clu;chrna2;ces1d;arntl;alox15;abcb1b;abcb1a SLC7A13_32952;SLC7A12_32838;SLC5A6_9881;SLC22A7_9847;PPARD_9536;PIK3R4_9484;FGG_8639;CLU_32773;CHRNA2_32401;CES1D_32914;ARNTL_8086;ALOX15_8036;ABCB1B_7939;ABCB1A_7938 273.21267142857147 107.09219999999999 11.0684 349.6778868302027 219.73691970484774 297.08929233600065 189.88139857142855 59.993449999999996 4.18343 274.3886332971852 145.38919910753575 227.94884298416693 608.7028214285714 191.29649999999998 17.0564 774.6895994750693 573.6204560060544 763.3876010179957 397.931;37.9163;120.077;49.1516;94.1074;955.628;42.4612;935.649;163.479;11.0684;22.9134;766.819;20.7941;206.982 280.111;15.3983;82.2177;13.5995;37.7692;735.228;20.6424;808.484;101.968;4.18343;11.4115;421.048;8.25355;118.025 668.129;132.15;221.286;161.307;148.485;1288.97;98.0534;1071.05;414.362;17.0564;50.1592;2662.07;57.2115;1531.55 0 14 0 14 313089;294881;170551;89776;25682;363131;24367;24854;170945;113902;29657;81639;24646;170913 SLC7A13_32952;SLC7A12_32838;SLC5A6_9881;SLC22A7_9847;PPARD_9536;PIK3R4_9484;FGG_8639;CLU_32773;CHRNA2_32401;CES1D_32914;ARNTL_8086;ALOX15_8036;ABCB1B_7939;ABCB1A_7938 273.21267142857147 107.09219999999999 349.6778868302027 189.88139857142855 59.993449999999996 274.3886332971852 608.7028214285714 191.29649999999998 774.6895994750693 397.931;37.9163;120.077;49.1516;94.1074;955.628;42.4612;935.649;163.479;11.0684;22.9134;766.819;20.7941;206.982 280.111;15.3983;82.2177;13.5995;37.7692;735.228;20.6424;808.484;101.968;4.18343;11.4115;421.048;8.25355;118.025 668.129;132.15;221.286;161.307;148.485;1288.97;98.0534;1071.05;414.362;17.0564;50.1592;2662.07;57.2115;1531.55 0 Exp 2,2(0.15);Exp 4,3(0.22);Exp 5,2(0.15);Hill,2(0.15);Poly 2,5(0.36) 2.0858632857077444 31.965006828308105 1.5018656253814697 6.191005229949951 1.2549370722692892 1.892466127872467 90.04019267360917 456.38515018353365 46.1478426441779 333.61495449867925 202.89559270197384 1014.510050155169 DOWN 0.0 1.0 0.0 GO:0019725 4 cellular homeostasis 217 230 18 17 9 10 7 7 61 223 2256 0.73227 0.41734 0.66749 3.04 24832;362282;24314;25283;245920;686019;81639 thy1;pck1;nqo1;gclc;cxcl10;casq1;alox15 THY1_33010;PCK1_9439;NQO1_33055;GCLC_8699;CXCL10_8408;CASQ1_32992;ALOX15_8036 324.5189000000008 147.66 5.72311E-12 321.54280913802035 224.91406914345882 281.54141670640445 185.28436285714366 96.6023 5.72311E-12 189.64727862877433 120.94239233652677 162.21067519355216 915.3618714285723 397.209 5.72313E-12 1027.4584216987957 665.7712386689558 957.2522294877549 5.72311E-12;529.244;25.6813;131.7;670.528;147.66;766.819 5.72311E-12;356.883;7.73944;39.9158;374.802;96.6023;421.048 5.72313E-12;1021.06;86.1211;397.209;1955.3;285.773;2662.07 2 5 2 362282;24314 PCK1_9439;NQO1_33055 277.46265 277.46265 356.0725999226071 182.31122 182.31122 246.8817788836122 553.59055 553.59055 661.1016361850914 529.244;25.6813 356.883;7.73944 1021.06;86.1211 5 24832;25283;245920;686019;81639 THY1_33010;GCLC_8699;CXCL10_8408;CASQ1_32992;ALOX15_8036 343.34140000000116 147.66 349.0526315526056 186.47362000000115 96.6023 196.73661211338236 1060.0704000000012 397.209 1175.851787782923 5.72311E-12;131.7;670.528;147.66;766.819 5.72311E-12;39.9158;374.802;96.6023;421.048 5.72313E-12;397.209;1955.3;285.773;2662.07 0 Exp 2,2(0.29);Hill,3(0.43);Linear,1(0.15);Poly 2,1(0.15) 1.8815223918730324 13.305099248886108 1.5021449327468872 2.327066659927368 0.2908113349686903 1.863204002380371 86.31665352471438 562.7211464752872 44.79169275700846 325.77703295727883 154.21002087186787 1676.5137219852768 DOWN 0.2857142857142857 0.7142857142857143 0.0 GO:0032354 6 response to follicle-stimulating hormone 20 22 4 4 3 4 3 3 65 19 2460 0.99763 0.019495 0.019495 13.64 25154;25283;25612 pgr;gclc;asns PGR_32824;GCLC_8699;ASNS_8091 202.1543333333333 191.145 131.7 76.5550373674609 174.70668020932982 62.38650026027873 97.39693333333332 113.564 39.9158 51.34348468124594 81.18206978785662 50.05186558161788 820.562 510.267 397.209 637.8675950140436 595.6509627482978 466.95017106965076 0.5 161.4225 1.5 237.38150000000002 283.618;131.7;191.145 138.711;39.9158;113.564 1554.21;397.209;510.267 0 3 0 3 25154;25283;25612 PGR_32824;GCLC_8699;ASNS_8091 202.1543333333333 191.145 76.5550373674609 97.39693333333332 113.564 51.34348468124594 820.562 510.267 637.8675950140436 283.618;131.7;191.145 138.711;39.9158;113.564 1554.21;397.209;510.267 0 Hill,1(0.34);Poly 2,2(0.67) 1.7643491860461202 5.320656418800354 1.5405861139297485 1.9746891260147095 0.2187948173066911 1.805381178855896 115.52415332675953 288.78451333990716 39.296310917705846 155.49755574896082 98.74686573015333 1542.3771342698467 DOWN 0.0 1.0 0.0 GO:0071371 6 cellular response to gonadotropin stimulus 23 25 3 3 3 3 3 3 65 22 2457 0.99615 0.027508 0.027508 12.0 25154;25283;114494 pgr;gclc;ccna2 PGR_32824;GCLC_8699;CCNA2_8221 143.234 131.7 14.384 134.98707921871633 113.3703985169238 107.15891102712969 61.17293000000001 39.9158 4.89199 69.3958287018946 42.075356365865325 52.07241208245599 669.8898 397.209 58.2504 784.3722937639499 446.7939524578399 584.6875213673059 0.5 73.042 1.5 207.659 283.618;131.7;14.384 138.711;39.9158;4.89199 1554.21;397.209;58.2504 0 3 0 3 25154;25283;114494 PGR_32824;GCLC_8699;CCNA2_8221 143.234 131.7 134.98707921871633 61.17293000000001 39.9158 69.3958287018946 669.8898 397.209 784.3722937639499 283.618;131.7;14.384 138.711;39.9158;4.89199 1554.21;397.209;58.2504 0 Exp 4,1(0.34);Hill,1(0.34);Poly 2,1(0.34) 1.7041423247924328 5.142070412635803 1.5405861139297485 1.9746891260147095 0.22982153571585182 1.6267951726913452 -9.51825998713258 295.98625998713254 -17.355842748085024 139.701702748085 -217.71100770102134 1557.4906077010214 DOWN 0.0 1.0 0.0 GO:0048869 3 cellular developmental process 541 573 41 38 26 26 20 20 48 553 1926 0.93361 0.11006 0.18442 3.49 360243;24832;25671;25682;25154;362282;259241;81687;362376;24426;24367;64191;312495;24296;24854;113902;24232;29657;24646;170913 top2a;thy1;smad1;ppard;pgr;pck1;nr1d2;mmp9;herc6;gstp1;fgg;dhcr7;cyp26b1;cyp1a1;clu;ces1d;c3;arntl;abcb1b;abcb1a TOP2A_10059;THY1_33010;SMAD1_32578;PPARD_9536;PGR_32824;PCK1_9439;NR1D2_9358;MMP9_32531;HERC6_8794;GSTP1_8762;FGG_8639;DHCR7_8466;CYP26B1_8418;CYP1A1_8415;CLU_32773;CES1D_32914;C3_8175;ARNTL_8086;ABCB1B_7939;ABCB1A_7938 174.7348000000003 41.07385 5.72311E-12 261.8461028058615 170.48194195188427 257.02936298715656 110.34868950000029 18.20765 5.72311E-12 203.860866477627 102.59809008617464 195.90256453761316 472.9631350000003 131.2615 5.72313E-12 628.352967420306 493.2395242916641 655.8982702798249 86.3883;5.72311E-12;21.9973;94.1074;283.618;529.244;29.1728;728.316;39.6865;14.7631;42.4612;161.702;18.1872;12.8863;935.649;11.0684;234.759;22.9134;20.7941;206.982 26.6888;5.72311E-12;5.02186;37.7692;138.711;356.883;3.35457;443.137;15.7729;9.42992;20.6424;50.9087;10.0176;9.13136;808.484;4.18343;129.148;11.4115;8.25355;118.025 262.273;5.72313E-12;80.1461;148.485;1554.21;1021.06;114.038;2039.06;157.407;25.7196;98.0534;481.517;36.7271;19.3234;1071.05;17.0564;694.216;50.1592;57.2115;1531.55 5 15 5 362282;259241;24426;312495;24296 PCK1_9439;NR1D2_9358;GSTP1_8762;CYP26B1_8418;CYP1A1_8415 120.85068000000001 18.1872 228.38597242752672 77.76329 9.42992 156.05587133073558 243.37362 36.7271 436.4053064441952 529.244;29.1728;14.7631;18.1872;12.8863 356.883;3.35457;9.42992;10.0176;9.13136 1021.06;114.038;25.7196;36.7271;19.3234 15 360243;24832;25671;25682;25154;81687;362376;24367;64191;24854;113902;24232;29657;24646;170913 TOP2A_10059;THY1_33010;SMAD1_32578;PPARD_9536;PGR_32824;MMP9_32531;HERC6_8794;FGG_8639;DHCR7_8466;CLU_32773;CES1D_32914;C3_8175;ARNTL_8086;ABCB1B_7939;ABCB1A_7938 192.69617333333372 86.3883 277.0645855610858 121.21048933333371 26.6888 221.2195649922144 549.4929733333337 157.407 675.5164292367097 86.3883;5.72311E-12;21.9973;94.1074;283.618;728.316;39.6865;42.4612;161.702;935.649;11.0684;234.759;22.9134;20.7941;206.982 26.6888;5.72311E-12;5.02186;37.7692;138.711;443.137;15.7729;20.6424;50.9087;808.484;4.18343;129.148;11.4115;8.25355;118.025 262.273;5.72313E-12;80.1461;148.485;1554.21;2039.06;157.407;98.0534;481.517;1071.05;17.0564;694.216;50.1592;57.2115;1531.55 0 Exp 4,10(0.5);Exp 5,2(0.1);Hill,2(0.1);Linear,2(0.1);Poly 2,4(0.2) 2.3261443479608643 58.584996700286865 1.5405861139297485 15.48720932006836 3.149414728545473 1.9131878018379211 59.97568563860857 289.493914361392 21.002725442387813 199.69465355761275 197.57530499295933 748.3509650070412 DOWN 0.25 0.75 0.0 GO:0033674 8 positive regulation of kinase activity 157 169 8 8 4 5 3 3 65 166 2313 0.32816 0.84098 0.62295 1.78 363131;361921;24854 pik3r4;ect2;clu PIK3R4_9484;ECT2_8523;CLU_32773 633.7644 935.649 10.0162 540.2741460246641 449.10415835116015 569.8366872794272 515.6686833333333 735.228 3.29405 445.238625959834 371.62373090340634 478.82452203827313 799.2501666666667 1071.05 37.7305 668.435811159219 557.3065487905216 679.6140127110164 955.628;10.0162;935.649 735.228;3.29405;808.484 1288.97;37.7305;1071.05 0 3 0 3 363131;361921;24854 PIK3R4_9484;ECT2_8523;CLU_32773 633.7644 935.649 540.2741460246641 515.6686833333333 735.228 445.238625959834 799.2501666666667 1071.05 668.435811159219 955.628;10.0162;935.649 735.228;3.29405;808.484 1288.97;37.7305;1071.05 0 Exp 4,1(0.34);Poly 2,2(0.67) 1.563221676262923 4.692560076713562 1.5018656253814697 1.6358354091644287 0.06747021219462065 1.5548590421676636 22.38664965867156 1245.1421503413285 11.83374785233616 1019.5036188143305 42.84383946949481 1555.6564938638385 DOWN 0.0 1.0 0.0 GO:0044087 5 regulation of cellular component biogenesis 211 228 11 10 8 9 7 7 61 221 2258 0.74009 0.40824 0.66548 3.07 684352;24832;361921;24854;29397;246142;81639 twf2;thy1;ect2;clu;ccl11;bmf;alox15 TWF2_10109;THY1_33010;ECT2_8523;CLU_32773;CCL11_33230;BMF_8152;ALOX15_8036 422.3943142857151 138.399 5.72311E-12 451.142593425505 401.88581231486467 445.1378012872745 279.76642142857224 90.7363 5.72311E-12 317.2178888409895 260.5936833657881 304.2093481010907 931.5657857142867 299.165 5.72313E-12 1101.1477444229056 916.8149847760673 1116.4476633016577 138.399;5.72311E-12;10.0162;935.649;986.476;119.401;766.819 90.7363;5.72311E-12;3.29405;808.484;552.974;81.8286;421.048 299.165;5.72313E-12;37.7305;1071.05;2230.86;220.085;2662.07 1 6 1 29397 CCL11_33230 986.476 986.476 552.974 552.974 2230.86 2230.86 986.476 552.974 2230.86 6 684352;24832;361921;24854;246142;81639 TWF2_10109;THY1_33010;ECT2_8523;CLU_32773;BMF_8152;ALOX15_8036 328.3807000000009 128.9 412.3004563256015 234.23182500000098 86.28245 321.45928394870356 715.016750000001 259.625 1030.1098743140817 138.399;5.72311E-12;10.0162;935.649;119.401;766.819 90.7363;5.72311E-12;3.29405;808.484;81.8286;421.048 299.165;5.72313E-12;37.7305;1071.05;220.085;2662.07 0 Exp 2,1(0.15);Exp 4,1(0.15);Hill,1(0.15);Poly 2,3(0.43);Power,1(0.15) 1.6973569048679549 11.935566663742065 1.5021449327468872 1.9814788103103638 0.17715781057172444 1.6358354091644287 88.18320403658436 756.6054245348458 44.7681207461992 514.7647221109453 115.82412093912512 1747.3074504894482 DOWN 0.14285714285714285 0.8571428571428571 0.0 GO:0014910 7 regulation of smooth muscle cell migration 45 50 4 4 3 4 3 3 65 47 2432 0.95739 0.14723 0.14723 6.0 25682;25154;24426 ppard;pgr;gstp1 PPARD_9536;PGR_32824;GSTP1_8762 130.8295 94.1074 14.7631 138.1380605945009 115.17058345595963 126.5327308665672 61.970040000000004 37.7692 9.42992 67.95336565631463 53.639158646205594 62.135715611446294 576.1382 148.485 25.7196 849.2562453851723 460.31208206853063 778.2548378201202 1.5 188.8627 94.1074;283.618;14.7631 37.7692;138.711;9.42992 148.485;1554.21;25.7196 1 2 1 24426 GSTP1_8762 14.7631 14.7631 9.42992 9.42992 25.7196 25.7196 14.7631 9.42992 25.7196 2 25682;25154 PPARD_9536;PGR_32824 188.8627 188.8627 134.00423036673135 88.24010000000001 88.24010000000001 71.37663128517625 851.3475000000001 851.3475000000001 993.9976799834594 94.1074;283.618 37.7692;138.711 148.485;1554.21 0 Exp 4,1(0.34);Exp 5,1(0.34);Poly 2,1(0.34) 2.192456832030237 7.0076751708984375 1.5405861139297485 3.5281898975372314 1.051591423593817 1.9388991594314575 -25.48843108035311 287.14743108035316 -14.926432149868091 138.86651214986813 -384.8857108928362 1537.1621108928362 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0017038 6 protein import 28 30 2 2 2 2 2 2 66 28 2451 0.95581 0.19005 0.19005 6.67 24854;29657 clu;arntl CLU_32773;ARNTL_8086 479.2812 479.2812 22.9134 645.4015321903721 722.354458254717 546.2361394090943 409.94775000000004 409.94775000000004 11.4115 563.6153698473145 622.2184334709119 477.01635087878157 560.6046 560.6046 50.1592 721.8788075309593 832.4809824685534 610.9627468790102 0.5 479.2812 935.649;22.9134 808.484;11.4115 1071.05;50.1592 0 2 0 2 24854;29657 CLU_32773;ARNTL_8086 479.2812 479.2812 645.4015321903721 409.94775000000004 409.94775000000004 563.6153698473145 560.6046 560.6046 721.8788075309593 935.649;22.9134 808.484;11.4115 1071.05;50.1592 0 Exp 4,1(0.5);Poly 2,1(0.5) 2.31373022460303 4.997838377952576 1.5548590421676636 3.442979335784912 1.3351026633126917 2.498919188976288 -415.1996879999999 1373.762088 -371.1832999999998 1191.0787999999998 -439.8683839999999 1561.077584 DOWN 0.0 1.0 0.0 GO:0043933 5 protein-containing complex subunit organization 226 259 14 14 10 12 9 9 59 250 2229 0.85328 0.2499 0.41261 3.47 684352;25671;316273;24367;309186;361921;24854;113902;686019 twf2;smad1;mcm3;fgg;fermt3;ect2;clu;ces1d;casq1 TWF2_10109;SMAD1_32578;MCM3_9207;FGG_8639;FERMT3_32542;ECT2_8523;CLU_32773;CES1D_32914;CASQ1_32992 227.07078888888887 138.399 10.0162 313.13249057989196 212.40347506319347 300.3600160297336 164.40281555555555 90.7363 3.29405 263.08512846990726 154.80761396216374 253.84061115271803 397.08326666666665 285.773 17.0564 443.6955876621577 362.4227820903067 413.9252735494398 138.399;21.9973;197.273;42.4612;539.113;10.0162;935.649;11.0684;147.66 90.7363;5.02186;116.413;20.6424;334.248;3.29405;808.484;4.18343;96.6023 299.165;80.1461;496.915;98.0534;1187.86;37.7305;1071.05;17.0564;285.773 0 9 0 9 684352;25671;316273;24367;309186;361921;24854;113902;686019 TWF2_10109;SMAD1_32578;MCM3_9207;FGG_8639;FERMT3_32542;ECT2_8523;CLU_32773;CES1D_32914;CASQ1_32992 227.07078888888887 138.399 313.13249057989196 164.40281555555555 90.7363 263.08512846990726 397.08326666666665 285.773 443.6955876621577 138.399;21.9973;197.273;42.4612;539.113;10.0162;935.649;11.0684;147.66 90.7363;5.02186;116.413;20.6424;334.248;3.29405;808.484;4.18343;96.6023 299.165;80.1461;496.915;98.0534;1187.86;37.7305;1071.05;17.0564;285.773 0 Exp 2,1(0.12);Exp 4,3(0.34);Exp 5,1(0.12);Poly 2,4(0.45) 1.8178841493761853 16.69490396976471 1.5548590421676636 2.8176381587982178 0.4304556494391186 1.6703740358352661 22.4908950433595 431.65068273441824 -7.47946837811719 336.2850994892283 107.2021493940569 686.9643839392763 DOWN 0.0 1.0 0.0 GO:0065003 6 protein-containing complex assembly 203 233 13 13 9 11 8 8 60 225 2254 0.83615 0.2796 0.39681 3.43 25671;316273;24367;309186;361921;24854;113902;686019 smad1;mcm3;fgg;fermt3;ect2;clu;ces1d;casq1 SMAD1_32578;MCM3_9207;FGG_8639;FERMT3_32542;ECT2_8523;CLU_32773;CES1D_32914;CASQ1_32992 238.1547625 95.0606 10.0162 332.8599300738287 219.10792273294447 315.1707632166697 173.61113 58.62235 3.29405 279.69503254766147 160.6121652575375 266.3164607553643 409.32304999999997 191.91320000000002 17.0564 472.7034272249598 368.15363133106985 435.1669831863466 21.9973;197.273;42.4612;539.113;10.0162;935.649;11.0684;147.66 5.02186;116.413;20.6424;334.248;3.29405;808.484;4.18343;96.6023 80.1461;496.915;98.0534;1187.86;37.7305;1071.05;17.0564;285.773 0 8 0 8 25671;316273;24367;309186;361921;24854;113902;686019 SMAD1_32578;MCM3_9207;FGG_8639;FERMT3_32542;ECT2_8523;CLU_32773;CES1D_32914;CASQ1_32992 238.1547625 95.0606 332.8599300738287 173.61113 58.62235 279.69503254766147 409.32304999999997 191.91320000000002 472.7034272249598 21.9973;197.273;42.4612;539.113;10.0162;935.649;11.0684;147.66 5.02186;116.413;20.6424;334.248;3.29405;808.484;4.18343;96.6023 80.1461;496.915;98.0534;1187.86;37.7305;1071.05;17.0564;285.773 0 Exp 2,1(0.13);Exp 4,3(0.38);Exp 5,1(0.13);Poly 2,3(0.38) 1.8208083900818555 14.900245308876038 1.5548590421676636 2.8176381587982178 0.4595404172705172 1.6531047224998474 7.494599034325432 468.81492596567466 -20.207639095070675 367.4298990950706 81.75628709672708 736.8898129032729 DOWN 0.0 1.0 0.0 GO:0009624 5 response to nematode 1 1 1 1 1 1 1 1 67 0 2479 1.0 0.026698 0.026698 100.0 24296 cyp1a1 CYP1A1_8415 12.8863 12.8863 12.8863 12.886299999999999 9.13136 9.13136 9.13136 9.13136 19.3234 19.3234 19.3234 19.3234 0.0 12.8863 0.0 12.8863 12.8863 9.13136 19.3234 1 0 1 24296 CYP1A1_8415 12.8863 12.8863 9.13136 9.13136 19.3234 19.3234 12.8863 9.13136 19.3234 0 0 Exp 4,1(1) 15.487209320068361 15.48720932006836 15.48720932006836 15.48720932006836 0.0 15.48720932006836 12.8863 12.8863 9.13136 9.13136 19.3234 19.3234 UP 1.0 0.0 0.0 GO:0019341 5 dibenzo-p-dioxin catabolic process 1 1 1 1 1 1 1 1 67 0 2479 1.0 0.026698 0.026698 100.0 24296 cyp1a1 CYP1A1_8415 12.8863 12.8863 12.8863 12.886299999999999 9.13136 9.13136 9.13136 9.13136 19.3234 19.3234 19.3234 19.3234 0.0 12.8863 0.0 12.8863 12.8863 9.13136 19.3234 1 0 1 24296 CYP1A1_8415 12.8863 12.8863 9.13136 9.13136 19.3234 19.3234 12.8863 9.13136 19.3234 0 0 Exp 4,1(1) 15.487209320068361 15.48720932006836 15.48720932006836 15.48720932006836 0.0 15.48720932006836 12.8863 12.8863 9.13136 9.13136 19.3234 19.3234 UP 1.0 0.0 0.0 GO:0045664 8 regulation of neuron differentiation 157 165 11 9 6 5 5 5 63 160 2319 0.72409 0.4533 0.80038 3.03 684352;24832;25671;338475;361921 twf2;thy1;smad1;nrep;ect2 TWF2_10109;THY1_33010;SMAD1_32578;NREP_9364;ECT2_8523 46.391100000001146 21.9973 5.72311E-12 56.491943504537595 42.88131016995124 54.35494328172747 24.944822000001146 5.02186 5.72311E-12 38.134537192364725 22.896721731977664 35.864094388426906 113.16592000000114 80.1461 5.72313E-12 117.74116410290277 104.0744482409623 114.30774989151654 138.399;5.72311E-12;21.9973;61.543;10.0162 90.7363;5.72311E-12;5.02186;25.6719;3.29405 299.165;5.72313E-12;80.1461;148.788;37.7305 0 5 0 5 684352;24832;25671;338475;361921 TWF2_10109;THY1_33010;SMAD1_32578;NREP_9364;ECT2_8523 46.391100000001146 21.9973 56.491943504537595 24.944822000001146 5.02186 38.134537192364725 113.16592000000114 80.1461 117.74116410290277 138.399;5.72311E-12;21.9973;61.543;10.0162 90.7363;5.72311E-12;5.02186;25.6719;3.29405 299.165;5.72313E-12;80.1461;148.788;37.7305 0 Exp 4,3(0.6);Hill,1(0.2);Poly 2,1(0.2) 1.7528033208688476 8.773285269737244 1.6358354091644287 1.863204002380371 0.08983601306388223 1.7863717079162598 -3.1262717360305743 95.90847173603285 -8.481573641426483 58.37121764142877 9.961239299854128 216.3706007001482 DOWN 0.0 1.0 0.0 GO:0050793 4 regulation of developmental process 584 616 41 39 24 25 17 17 51 599 1880 0.62686 0.48442 0.88601 2.76 684352;24832;25671;25682;338475;259241;81687;81919;361921;312495;245920;84032;24854;29397;24232;29657;170913 twf2;thy1;smad1;ppard;nrep;nr1d2;mmp9;fut1;ect2;cyp26b1;cxcl10;col3a1;clu;ccl11;c3;arntl;abcb1a TWF2_10109;THY1_33010;SMAD1_32578;PPARD_9536;NREP_9364;NR1D2_9358;MMP9_32531;FUT1_8668;ECT2_8523;CYP26B1_8418;CXCL10_8408;COL3A1_8354;CLU_32773;CCL11_33230;C3_8175;ARNTL_8086;ABCB1A_7938 271.324135294118 138.399 5.72311E-12 336.56324180299083 283.8711735783735 340.78766558432 165.44879882352976 78.9726 5.72311E-12 236.210198263555 169.8710207905152 237.55708534315878 752.6961705882356 299.165 5.72313E-12 808.5683025098749 805.620335075745 817.4181908834719 138.399;5.72311E-12;21.9973;94.1074;61.543;29.1728;728.316;240.861;10.0162;18.1872;670.528;212.603;935.649;986.476;234.759;22.9134;206.982 90.7363;5.72311E-12;5.02186;37.7692;25.6719;3.35457;443.137;78.9726;3.29405;10.0176;374.802;119.81;808.484;552.974;129.148;11.4115;118.025 299.165;5.72313E-12;80.1461;148.485;148.788;114.038;2039.06;847.87;37.7305;36.7271;1955.3;1510.69;1071.05;2230.86;694.216;50.1592;1531.55 3 14 3 259241;312495;29397 NR1D2_9358;CYP26B1_8418;CCL11_33230 344.612 29.1728 555.8976674927139 188.78205666666668 10.0176 315.4170694237673 793.8750333333334 114.038 1245.0656969149072 29.1728;18.1872;986.476 3.35457;10.0176;552.974 114.038;36.7271;2230.86 14 684352;24832;25671;25682;338475;81687;81919;361921;245920;84032;24854;24232;29657;170913 TWF2_10109;THY1_33010;SMAD1_32578;PPARD_9536;NREP_9364;MMP9_32531;FUT1_8668;ECT2_8523;CXCL10_8408;COL3A1_8354;CLU_32773;C3_8175;ARNTL_8086;ABCB1A_7938 255.61959285714326 172.6905 300.61301827019645 160.44881500000042 84.85445 230.6787557074442 743.872128571429 496.69050000000004 752.1236001970922 138.399;5.72311E-12;21.9973;94.1074;61.543;728.316;240.861;10.0162;670.528;212.603;935.649;234.759;22.9134;206.982 90.7363;5.72311E-12;5.02186;37.7692;25.6719;443.137;78.9726;3.29405;374.802;119.81;808.484;129.148;11.4115;118.025 299.165;5.72313E-12;80.1461;148.485;148.788;2039.06;847.87;37.7305;1955.3;1510.69;1071.05;694.216;50.1592;1531.55 0 Exp 2,2(0.12);Exp 4,6(0.36);Exp 5,1(0.06);Hill,1(0.06);Linear,1(0.06);Poly 2,5(0.3);Power,1(0.06) 1.937024291631254 33.65359652042389 1.5467612743377686 3.442979335784912 0.47349006327066273 1.863204002380371 111.33212591283007 431.316144675406 53.16159819494722 277.73599945211237 368.327198065989 1137.065143110482 DOWN 0.17647058823529413 0.8235294117647058 0.0 GO:0002253 6 activation of immune response 62 69 5 5 4 4 3 3 65 66 2413 0.88973 0.27939 0.43002 4.35 24832;295703;24232 thy1;serping1;c3 THY1_33010;SERPING1_32597;C3_8175 89.0529000000019 32.3997 5.72311E-12 127.22081521091386 74.87601152135446 120.29288364896462 47.62626666666858 13.7308 5.72311E-12 70.93291528911708 39.740339679717444 66.98392085128324 264.56816666666856 99.4885 5.72313E-12 375.3963717513554 222.72306338968184 355.0384987866947 5.72311E-12;32.3997;234.759 5.72311E-12;13.7308;129.148 5.72313E-12;99.4885;694.216 0 3 0 3 24832;295703;24232 THY1_33010;SERPING1_32597;C3_8175 89.0529000000019 32.3997 127.22081521091386 47.62626666666858 13.7308 70.93291528911708 264.56816666666856 99.4885 375.3963717513554 5.72311E-12;32.3997;234.759 5.72311E-12;13.7308;129.148 5.72313E-12;99.4885;694.216 0 Exp 4,1(0.34);Hill,1(0.34);Poly 2,1(0.34) 1.7044947761190992 5.128282427787781 1.5467612743377686 1.863204002380371 0.15840855335441092 1.7183171510696411 -54.9110049407458 233.01680494074964 -32.641883297021685 127.89441663035885 -160.23281804890104 689.3691513822382 DOWN 0.0 1.0 0.0 GO:0032642 6 regulation of chemokine production 31 34 2 2 2 2 2 2 66 32 2447 0.93957 0.22956 0.22956 5.88 688621;24426 tslp;gstp1 TSLP_32811;GSTP1_8762 179.71905 179.71905 14.7631 233.28294168413817 233.82069484034682 220.3791163698207 126.81496 126.81496 9.42992 166.00751558770824 165.31447301332207 156.82496684864077 293.0773 293.0773 25.7196 378.10088534487716 380.7642935927257 357.1865924246297 0.5 179.71905 344.675;14.7631 244.2;9.42992 560.435;25.7196 1 1 1 24426 GSTP1_8762 14.7631 14.7631 9.42992 9.42992 25.7196 25.7196 14.7631 9.42992 25.7196 1 688621 TSLP_32811 344.675 344.675 244.2 244.2 560.435 560.435 344.675 244.2 560.435 0 Exp 2,1(0.5);Exp 4,1(0.5) 2.4388610428832975 5.214052438735962 1.6858625411987305 3.5281898975372314 1.302722166832439 2.607026219367981 -143.594612 503.03271200000006 -103.25971839999995 356.88963839999997 -230.94379199999997 817.0983919999999 CONFLICT 0.5 0.5 0.0 GO:0016129 6 phytosteroid biosynthetic process 2 2 2 2 2 2 2 2 66 0 2479 1.0 7.0258E-4 7.0258E-4 100.0 64191;312495 dhcr7;cyp26b1 DHCR7_8466;CYP26B1_8418 89.9446 89.9446 18.1872 101.48028828063113 102.81191800829876 99.83543040457438 30.463150000000002 30.463150000000002 10.0176 28.914374100177234 34.12938363868497 28.4457113009703 259.12205 259.12205 36.7271 314.51395449328635 299.00123382061923 309.4161097399543 0.0 18.1872 0.0 18.1872 161.702;18.1872 50.9087;10.0176 481.517;36.7271 1 1 1 312495 CYP26B1_8418 18.1872 18.1872 10.0176 10.0176 36.7271 36.7271 18.1872 10.0176 36.7271 1 64191 DHCR7_8466 161.702 161.702 50.9087 50.9087 481.517 481.517 161.702 50.9087 481.517 0 Exp 4,2(1) 1.935858350977881 3.883132576942444 1.7927976846694946 2.090334892272949 0.21039057715171233 1.941566288471222 -50.69990400000002 230.58910400000002 -9.610127999999992 70.536428 -176.77205199999992 695.0161519999999 CONFLICT 0.5 0.5 0.0 GO:0030100 6 regulation of endocytosis 51 53 4 4 3 3 3 3 65 50 2429 0.94893 0.16659 0.16659 5.66 24854;24232;81639 clu;c3;alox15 CLU_32773;C3_8175;ALOX15_8036 645.7423333333332 766.819 234.759 365.79552680880806 710.943392803598 317.71728202499355 452.8933333333334 421.048 129.148 340.785774593561 491.766737454802 311.91124432491614 1475.7786666666668 1071.05 694.216 1044.4933276691302 1693.6127734368108 1068.9105145425297 1.5 851.2339999999999 935.649;234.759;766.819 808.484;129.148;421.048 1071.05;694.216;2662.07 0 3 0 3 24854;24232;81639 CLU_32773;C3_8175;ALOX15_8036 645.7423333333332 766.819 365.79552680880806 452.8933333333334 421.048 340.785774593561 1475.7786666666668 1071.05 1044.4933276691302 935.649;234.759;766.819 808.484;129.148;421.048 1071.05;694.216;2662.07 0 Exp 2,1(0.34);Poly 2,2(0.67) 1.534412226286143 4.603765249252319 1.5021449327468872 1.5548590421676636 0.028387113017490508 1.5467612743377686 231.8057274253378 1059.6789392413286 67.25792628606177 838.528740380605 293.8231990294473 2657.734134303886 DOWN 0.0 1.0 0.0 GO:0065007 2 biological regulation 1742 1890 114 111 75 72 51 51 17 1839 640 0.60723 0.50409 1.0 2.7 116669;286989;684352;315852;688621;360243;24832;25671;295703;25682;288583;363131;25154;362282;304545;300795;338475;259241;24314;316351;81687;291234;24426;156275;25283;81919;24367;309186;29243;361921;64191;312495;24296;245920;84032;24854;306575;170945;113902;114494;29397;686019;24232;246142;25612;29657;29221;81639;252898;24646;170913 vwf;ugt2b7;twf2;ttk;tslp;top2a;thy1;smad1;serping1;ppard;plod3;pik3r4;pgr;pck1;oasl;pclaf;nrep;nr1d2;nqo1;npas2;mmp9;mki67;gstp1;ggt7;gclc;fut1;fgg;fermt3;f10;ect2;dhcr7;cyp26b1;cyp1a1;cxcl10;col3a1;clu;ckap2;chrna2;ces1d;ccna2;ccl11;casq1;c3;bmf;asns;arntl;arg1;alox15;acox2;abcb1b;abcb1a VWF_32396;UGT2B7_33032;TWF2_10109;TTK_32727;TSLP_32811;TOP2A_10059;THY1_33010;SMAD1_32578;SERPING1_32597;PPARD_9536;PLOD3_9507;PIK3R4_9484;PGR_32824;PCK1_9439;OASL_9389;NS5ATP9_9367;NREP_9364;NR1D2_9358;NQO1_33055;NPAS2_9350;MMP9_32531;MKI67_9232;GSTP1_8762;GGT7_33026;GCLC_8699;FUT1_8668;FGG_8639;FERMT3_32542;F10_8585;ECT2_8523;DHCR7_8466;CYP26B1_8418;CYP1A1_8415;CXCL10_8408;COL3A1_8354;CLU_32773;CKAP2_8324;CHRNA2_32401;CES1D_32914;CCNA2_8221;CCL11_33230;CASQ1_32992;C3_8175;BMF_8152;ASNS_8091;ARNTL_8086;ARG1_33267;ALOX15_8036;ACOX2_32902;ABCB1B_7939;ABCB1A_7938 255.765780392157 119.401 5.72311E-12 307.4346652759879 214.41031815849698 276.54581214150903 153.86091274509815 39.9158 5.72311E-12 210.06531254446267 123.65381002348231 183.10428231493742 668.0103764705883 285.773 5.72313E-12 785.7778650515621 589.0419393334915 755.1093080889857 19.6764;34.7126;138.399;737.351;344.675;86.3883;5.72311E-12;21.9973;32.3997;94.1074;882.629;955.628;283.618;529.244;76.6126;292.216;61.543;29.1728;25.6813;21.0878;728.316;21.9311;14.7631;109.609;131.7;240.861;42.4612;539.113;104.19;10.0162;161.702;18.1872;12.8863;670.528;212.603;935.649;32.2386;163.479;11.0684;14.384;986.476;147.66;234.759;119.401;191.145;22.9134;760.927;766.819;743.353;20.7941;206.982 4.11644;14.7729;90.7363;446.625;244.2;26.6888;5.72311E-12;5.02186;13.7308;37.7692;625.677;735.228;138.711;356.883;28.4477;147.515;25.6719;3.35457;7.73944;11.3305;443.137;6.82654;9.42992;29.3336;39.9158;78.9726;20.6424;334.248;38.4229;3.29405;50.9087;10.0176;9.13136;374.802;119.81;808.484;15.2683;101.968;4.18343;4.89199;552.974;96.6023;129.148;81.8286;113.564;11.4115;413.607;421.048;432.537;8.25355;118.025 94.078;105.024;299.165;2108.09;560.435;262.273;5.72313E-12;80.1461;99.4885;148.485;1106.02;1288.97;1554.21;1021.06;260.389;658.494;148.788;114.038;86.1211;43.5624;2039.06;76.1794;25.7196;346.073;397.209;847.87;98.0534;1187.86;163.044;37.7305;481.517;36.7271;19.3234;1955.3;1510.69;1071.05;76.7052;414.362;17.0564;58.2504;2230.86;285.773;694.216;220.085;510.267;50.1592;2639.93;2662.07;2287.79;57.2115;1531.55 8 43 8 286989;362282;259241;24314;24426;312495;24296;29397 UGT2B7_33032;PCK1_9439;NR1D2_9358;NQO1_33055;GSTP1_8762;CYP26B1_8418;CYP1A1_8415;CCL11_33230 206.39041250000002 27.42705 361.71978445398645 120.53784875 9.723759999999999 212.96303656369287 454.85915 95.57255 792.6411919166706 34.7126;529.244;29.1728;25.6813;14.7631;18.1872;12.8863;986.476 14.7729;356.883;3.35457;7.73944;9.42992;10.0176;9.13136;552.974 105.024;1021.06;114.038;86.1211;25.7196;36.7271;19.3234;2230.86 43 116669;684352;315852;688621;360243;24832;25671;295703;25682;288583;363131;25154;304545;300795;338475;316351;81687;291234;156275;25283;81919;24367;309186;29243;361921;64191;245920;84032;24854;306575;170945;113902;114494;686019;24232;246142;25612;29657;29221;81639;252898;24646;170913 VWF_32396;TWF2_10109;TTK_32727;TSLP_32811;TOP2A_10059;THY1_33010;SMAD1_32578;SERPING1_32597;PPARD_9536;PLOD3_9507;PIK3R4_9484;PGR_32824;OASL_9389;NS5ATP9_9367;NREP_9364;NPAS2_9350;MMP9_32531;MKI67_9232;GGT7_33026;GCLC_8699;FUT1_8668;FGG_8639;FERMT3_32542;F10_8585;ECT2_8523;DHCR7_8466;CXCL10_8408;COL3A1_8354;CLU_32773;CKAP2_8324;CHRNA2_32401;CES1D_32914;CCNA2_8221;CASQ1_32992;C3_8175;BMF_8152;ASNS_8091;ARNTL_8086;ARG1_33267;ALOX15_8036;ACOX2_32902;ABCB1B_7939;ABCB1A_7938 264.95189534883735 138.399 300.2690577326757 160.06055255813965 78.9726 211.4779540135091 707.6664186046513 346.073 787.4505700507705 19.6764;138.399;737.351;344.675;86.3883;5.72311E-12;21.9973;32.3997;94.1074;882.629;955.628;283.618;76.6126;292.216;61.543;21.0878;728.316;21.9311;109.609;131.7;240.861;42.4612;539.113;104.19;10.0162;161.702;670.528;212.603;935.649;32.2386;163.479;11.0684;14.384;147.66;234.759;119.401;191.145;22.9134;760.927;766.819;743.353;20.7941;206.982 4.11644;90.7363;446.625;244.2;26.6888;5.72311E-12;5.02186;13.7308;37.7692;625.677;735.228;138.711;28.4477;147.515;25.6719;11.3305;443.137;6.82654;29.3336;39.9158;78.9726;20.6424;334.248;38.4229;3.29405;50.9087;374.802;119.81;808.484;15.2683;101.968;4.18343;4.89199;96.6023;129.148;81.8286;113.564;11.4115;413.607;421.048;432.537;8.25355;118.025 94.078;299.165;2108.09;560.435;262.273;5.72313E-12;80.1461;99.4885;148.485;1106.02;1288.97;1554.21;260.389;658.494;148.788;43.5624;2039.06;76.1794;346.073;397.209;847.87;98.0534;1187.86;163.044;37.7305;481.517;1955.3;1510.69;1071.05;76.7052;414.362;17.0564;58.2504;285.773;694.216;220.085;510.267;50.1592;2639.93;2662.07;2287.79;57.2115;1531.55 0 Exp 2,8(0.16);Exp 4,19(0.38);Exp 5,3(0.06);Hill,5(0.1);Linear,3(0.06);Poly 2,12(0.24);Power,1(0.02) 2.050426990906443 119.96885514259338 1.5018656253814697 15.48720932006836 2.0945328384113684 1.805381178855896 171.38883116270335 340.14272962161044 96.20745913887657 211.51436635131967 452.34979386984503 883.6709590713316 DOWN 0.1568627450980392 0.8431372549019608 0.0 GO:0032412 6 regulation of ion transmembrane transporter activity 53 55 5 5 3 4 3 3 65 52 2427 0.94281 0.1799 0.1799 5.45 81687;686019;170913 mmp9;casq1;abcb1a MMP9_32531;CASQ1_32992;ABCB1A_7938 360.98600000000005 206.982 147.66 319.4969038911019 338.88900160485025 313.58057287015095 219.25476666666668 118.025 96.6023 194.18335103855665 206.69761495631244 189.82865599504018 1285.461 1531.55 285.773 902.177184943734 1170.649771175107 937.7038182820687 1.5 467.649 728.316;147.66;206.982 443.137;96.6023;118.025 2039.06;285.773;1531.55 0 3 0 3 81687;686019;170913 MMP9_32531;CASQ1_32992;ABCB1A_7938 360.98600000000005 206.982 319.4969038911019 219.25476666666668 118.025 194.18335103855665 1285.461 1531.55 902.177184943734 728.316;147.66;206.982 443.137;96.6023;118.025 2039.06;285.773;1531.55 0 Linear,1(0.34);Poly 2,2(0.67) 2.080861296734727 6.265889644622803 1.8874764442443848 2.327066659927368 0.22215405707114932 2.05134654045105 -0.5587819948881929 722.5307819948882 -0.48438092207177874 438.9939142554051 264.55140845535334 2306.3705915446467 DOWN 0.0 1.0 0.0 GO:0009719 3 response to endogenous stimulus 481 515 35 34 23 24 18 18 50 497 1982 0.92335 0.12691 0.21939 3.5 360243;25671;288583;25154;362282;24314;81687;24426;25283;25315;84032;113902;114494;24232;25612;29221;24646;170913 top2a;smad1;plod3;pgr;pck1;nqo1;mmp9;gstp1;gclc;ephx1;col3a1;ces1d;ccna2;c3;asns;arg1;abcb1b;abcb1a TOP2A_10059;SMAD1_32578;PLOD3_9507;PGR_32824;PCK1_9439;NQO1_33055;MMP9_32531;GSTP1_8762;GCLC_8699;EPHX1_8567;COL3A1_8354;CES1D_32914;CCNA2_8221;C3_8175;ASNS_8091;ARG1_33267;ABCB1B_7939;ABCB1A_7938 244.23542222222224 161.4225 11.0684 285.27281934773066 213.46611839148434 266.6444270154819 143.53586055555556 76.73989999999999 4.18343 187.1586639389546 118.43747334275572 166.16293825965292 759.5937 453.738 17.0564 806.1365844234635 720.7562459349498 838.1414326326003 86.3883;21.9973;882.629;283.618;529.244;25.6813;728.316;14.7631;131.7;39.2381;212.603;11.0684;14.384;234.759;191.145;760.927;20.7941;206.982 26.6888;5.02186;625.677;138.711;356.883;7.73944;443.137;9.42992;39.9158;18.9587;119.81;4.18343;4.89199;129.148;113.564;413.607;8.25355;118.025 262.273;80.1461;1106.02;1554.21;1021.06;86.1211;2039.06;25.7196;397.209;81.6965;1510.69;17.0564;58.2504;694.216;510.267;2639.93;57.2115;1531.55 4 14 4 362282;24314;24426;25315 PCK1_9439;NQO1_33055;GSTP1_8762;EPHX1_8567 152.231625 32.4597 251.5408831703424 98.252765 14.19431 172.49087608414644 303.6493 83.9088 479.06318088524256 529.244;25.6813;14.7631;39.2381 356.883;7.73944;9.42992;18.9587 1021.06;86.1211;25.7196;81.6965 14 360243;25671;288583;25154;81687;25283;84032;113902;114494;24232;25612;29221;24646;170913 TOP2A_10059;SMAD1_32578;PLOD3_9507;PGR_32824;MMP9_32531;GCLC_8699;COL3A1_8354;CES1D_32914;CCNA2_8221;C3_8175;ASNS_8091;ARG1_33267;ABCB1B_7939;ABCB1A_7938 270.5222214285714 199.0635 297.44019449158094 156.47388785714287 115.7945 195.26651916930416 889.8635285714287 602.2415 845.3459148124498 86.3883;21.9973;882.629;283.618;728.316;131.7;212.603;11.0684;14.384;234.759;191.145;760.927;20.7941;206.982 26.6888;5.02186;625.677;138.711;443.137;39.9158;119.81;4.18343;4.89199;129.148;113.564;413.607;8.25355;118.025 262.273;80.1461;1106.02;1554.21;2039.06;397.209;1510.69;17.0564;58.2504;694.216;510.267;2639.93;57.2115;1531.55 0 Exp 2,1(0.06);Exp 4,5(0.28);Exp 5,1(0.06);Hill,3(0.17);Linear,2(0.12);Poly 2,6(0.34) 1.9643631615304364 38.10805082321167 1.513624906539917 6.191005229949951 1.1153366314688304 1.7607250213623047 112.44610345688511 376.02474098755937 57.07296907524358 229.99875203586754 387.17759833318314 1132.0098016668167 DOWN 0.2222222222222222 0.7777777777777778 0.0 GO:0009064 8 glutamine family amino acid metabolic process 23 24 3 3 3 3 3 3 65 21 2458 0.9967 0.024669 0.024669 12.5 25283;25612;29221 gclc;asns;arg1 GCLC_8699;ASNS_8091;ARG1_33267 361.2573333333333 191.145 131.7 347.39791140180074 312.26374689298325 323.92073008877867 189.02893333333336 113.564 39.9158 197.94568790861123 159.6744216935055 186.52054448223 1182.4686666666666 510.267 397.209 1263.463763414817 1008.5076192755935 1173.8693786787503 0.5 161.4225 1.5 476.036 131.7;191.145;760.927 39.9158;113.564;413.607 397.209;510.267;2639.93 0 3 0 3 25283;25612;29221 GCLC_8699;ASNS_8091;ARG1_33267 361.2573333333333 191.145 347.39791140180074 189.02893333333336 113.564 197.94568790861123 1182.4686666666666 510.267 1263.463763414817 131.7;191.145;760.927 39.9158;113.564;413.607 397.209;510.267;2639.93 0 Exp 2,1(0.34);Hill,1(0.34);Poly 2,1(0.34) 1.7539961545474116 5.2936952114105225 1.513624906539917 1.9746891260147095 0.2332263270897845 1.805381178855896 -31.860410887603678 754.3750775542703 -34.96769921663292 413.02556588329963 -247.27517541434304 2612.212508747676 DOWN 0.0 1.0 0.0 GO:0007155 3 cell adhesion 145 150 13 12 10 7 6 6 62 144 2335 0.89808 0.20847 0.29037 4.0 116669;24832;25682;24367;309186;84032 vwf;thy1;ppard;fgg;fermt3;col3a1 VWF_32396;THY1_33010;PPARD_9536;FGG_8639;FERMT3_32542;COL3A1_8354 151.3268333333343 68.2843 5.72311E-12 204.6901641090708 107.53635463197602 178.28850562281832 86.09767333333428 29.205799999999996 5.72311E-12 129.20438979244656 58.953768297159165 112.33247372459839 506.52773333333425 123.26920000000001 5.72313E-12 662.4630589618909 337.4286158507368 549.1504336289082 19.6764;5.72311E-12;94.1074;42.4612;539.113;212.603 4.11644;5.72311E-12;37.7692;20.6424;334.248;119.81 94.078;5.72313E-12;148.485;98.0534;1187.86;1510.69 0 6 0 6 116669;24832;25682;24367;309186;84032 VWF_32396;THY1_33010;PPARD_9536;FGG_8639;FERMT3_32542;COL3A1_8354 151.3268333333343 68.2843 204.6901641090708 86.09767333333428 29.205799999999996 129.20438979244656 506.52773333333425 123.26920000000001 662.4630589618909 19.6764;5.72311E-12;94.1074;42.4612;539.113;212.603 4.11644;5.72311E-12;37.7692;20.6424;334.248;119.81 94.078;5.72313E-12;148.485;98.0534;1187.86;1510.69 0 Exp 2,1(0.17);Exp 4,1(0.17);Exp 5,1(0.17);Hill,2(0.34);Poly 2,1(0.17) 1.9637815147603335 11.994389414787292 1.6129854917526245 2.8176381587982178 0.43766207927964107 1.9010515809059143 -12.45940942836529 315.1130760950339 -17.287370322923792 189.48271698959235 -23.553112847305897 1036.6085795139743 DOWN 0.0 1.0 0.0 GO:0032501 2 multicellular organismal process 609 640 47 45 30 30 23 23 45 617 1862 0.96213 0.065609 0.11768 3.59 116669;25671;295703;25682;288583;25154;259241;316351;81687;25283;24367;29243;64191;312495;170945;113902;29397;24232;29657;29221;81639;24646;170913 vwf;smad1;serping1;ppard;plod3;pgr;nr1d2;npas2;mmp9;gclc;fgg;f10;dhcr7;cyp26b1;chrna2;ces1d;ccl11;c3;arntl;arg1;alox15;abcb1b;abcb1a VWF_32396;SMAD1_32578;SERPING1_32597;PPARD_9536;PLOD3_9507;PGR_32824;NR1D2_9358;NPAS2_9350;MMP9_32531;GCLC_8699;FGG_8639;F10_8585;DHCR7_8466;CYP26B1_8418;CHRNA2_32401;CES1D_32914;CCL11_33230;C3_8175;ARNTL_8086;ARG1_33267;ALOX15_8036;ABCB1B_7939;ABCB1A_7938 249.8027260869565 104.19 11.0684 322.5716509732982 232.854201567645 303.6534492532638 139.27714130434785 38.4229 3.35457 198.20392069788153 125.24834148771268 180.75031674541944 728.3936347826088 163.044 17.0564 907.5701850295899 715.6310291451265 902.8883955659869 19.6764;21.9973;32.3997;94.1074;882.629;283.618;29.1728;21.0878;728.316;131.7;42.4612;104.19;161.702;18.1872;163.479;11.0684;986.476;234.759;22.9134;760.927;766.819;20.7941;206.982 4.11644;5.02186;13.7308;37.7692;625.677;138.711;3.35457;11.3305;443.137;39.9158;20.6424;38.4229;50.9087;10.0176;101.968;4.18343;552.974;129.148;11.4115;413.607;421.048;8.25355;118.025 94.078;80.1461;99.4885;148.485;1106.02;1554.21;114.038;43.5624;2039.06;397.209;98.0534;163.044;481.517;36.7271;414.362;17.0564;2230.86;694.216;50.1592;2639.93;2662.07;57.2115;1531.55 3 20 3 259241;312495;29397 NR1D2_9358;CYP26B1_8418;CCL11_33230 344.612 29.1728 555.8976674927139 188.78205666666668 10.0176 315.4170694237673 793.8750333333334 114.038 1245.0656969149072 29.1728;18.1872;986.476 3.35457;10.0176;552.974 114.038;36.7271;2230.86 20 116669;25671;295703;25682;288583;25154;316351;81687;25283;24367;29243;64191;170945;113902;24232;29657;29221;81639;24646;170913 VWF_32396;SMAD1_32578;SERPING1_32597;PPARD_9536;PLOD3_9507;PGR_32824;NPAS2_9350;MMP9_32531;GCLC_8699;FGG_8639;F10_8585;DHCR7_8466;CHRNA2_32401;CES1D_32914;C3_8175;ARNTL_8086;ARG1_33267;ALOX15_8036;ABCB1B_7939;ABCB1A_7938 235.581335 117.945 293.8043165692418 131.851404 39.169349999999994 185.93074193976472 718.571425 280.1265 888.6971528610981 19.6764;21.9973;32.3997;94.1074;882.629;283.618;21.0878;728.316;131.7;42.4612;104.19;161.702;163.479;11.0684;234.759;22.9134;760.927;766.819;20.7941;206.982 4.11644;5.02186;13.7308;37.7692;625.677;138.711;11.3305;443.137;39.9158;20.6424;38.4229;50.9087;101.968;4.18343;129.148;11.4115;413.607;421.048;8.25355;118.025 94.078;80.1461;99.4885;148.485;1106.02;1554.21;43.5624;2039.06;397.209;98.0534;163.044;481.517;414.362;17.0564;694.216;50.1592;2639.93;2662.07;57.2115;1531.55 0 Exp 2,2(0.09);Exp 4,8(0.35);Exp 5,3(0.14);Hill,3(0.14);Linear,1(0.05);Poly 2,5(0.22);Power,1(0.05) 2.0254277463160637 49.70560157299042 1.5021449327468872 6.191005229949951 1.0128647051105024 1.8874764442443848 117.97148205048035 381.63397012343273 58.273527503605834 220.28075510508987 357.48036270226146 1099.3069068629557 DOWN 0.13043478260869565 0.8695652173913043 0.0 GO:0006508 5 proteolysis 170 184 10 10 5 8 5 5 63 179 2300 0.6324 0.55225 1.0 2.72 81687;156275;24367;29243;29657 mmp9;ggt7;fgg;f10;arntl MMP9_32531;GGT7_33026;FGG_8639;F10_8585;ARNTL_8086 201.49792 104.19 22.9134 296.9153092299082 261.13324446707406 331.6610924857827 108.58948000000001 29.3336 11.4115 187.2866354542069 145.97310023336726 210.13751718107198 539.27792 163.044 50.1592 845.8934020406425 702.7665804820094 948.9480735963186 728.316;109.609;42.4612;104.19;22.9134 443.137;29.3336;20.6424;38.4229;11.4115 2039.06;346.073;98.0534;163.044;50.1592 0 5 0 5 81687;156275;24367;29243;29657 MMP9_32531;GGT7_33026;FGG_8639;F10_8585;ARNTL_8086 201.49792 104.19 296.9153092299082 108.58948000000001 29.3336 187.2866354542069 539.27792 163.044 845.8934020406425 728.316;109.609;42.4612;104.19;22.9134 443.137;29.3336;20.6424;38.4229;11.4115 2039.06;346.073;98.0534;163.044;50.1592 0 Exp 4,3(0.6);Exp 5,1(0.2);Linear,1(0.2) 2.2564733230133687 11.765253186225891 1.5225032567977905 3.442979335784912 0.768590911885011 2.05134654045105 -58.759823479390604 461.75566347939065 -55.57449407590893 272.7534540759089 -202.18033828312298 1280.7361782831226 DOWN 0.0 1.0 0.0 GO:0002274 4 myeloid leukocyte activation 50 53 3 3 2 2 2 2 66 51 2428 0.83341 0.41668 0.65142 3.77 24832;24854 thy1;clu THY1_33010;CLU_32773 467.82450000000284 467.82450000000284 5.72311E-12 661.603752710408 501.456419381446 659.8918953873693 404.24200000000286 404.24200000000286 5.72311E-12 571.6845188808207 433.3029712714803 570.2053218144428 535.5250000000028 535.5250000000028 5.72313E-12 757.3467179898475 574.0239106529236 755.3871318781321 5.72311E-12;935.649 5.72311E-12;808.484 5.72313E-12;1071.05 0 2 0 2 24832;24854 THY1_33010;CLU_32773 467.82450000000284 467.82450000000284 661.603752710408 404.24200000000286 404.24200000000286 571.6845188808207 535.5250000000028 535.5250000000028 757.3467179898475 5.72311E-12;935.649 5.72311E-12;808.484 5.72313E-12;1071.05 0 Hill,1(0.5);Poly 2,1(0.5) 1.7020633332823139 3.4180630445480347 1.5548590421676636 1.863204002380371 0.21803281231110166 1.7090315222740173 -449.1115199999915 1384.7605199999973 -388.07231999999146 1196.5563199999974 -514.1039999999914 1585.153999999997 DOWN 0.0 1.0 0.0 GO:0009966 5 regulation of signal transduction 594 626 40 38 25 22 18 18 50 608 1871 0.70082 0.40274 0.67125 2.88 688621;24832;25682;338475;81687;24426;25283;24367;29243;312495;84032;24854;29397;24232;246142;29657;29221;81639 tslp;thy1;ppard;nrep;mmp9;gstp1;gclc;fgg;f10;cyp26b1;col3a1;clu;ccl11;c3;bmf;arntl;arg1;alox15 TSLP_32811;THY1_33010;PPARD_9536;NREP_9364;MMP9_32531;GSTP1_8762;GCLC_8699;FGG_8639;F10_8585;CYP26B1_8418;COL3A1_8354;CLU_32773;CCL11_33230;C3_8175;BMF_8152;ARNTL_8086;ARG1_33267;ALOX15_8036 309.97168333333366 125.5505 5.72311E-12 350.9353545178942 322.0053181455955 348.48437760890397 189.30654555555586 60.87219999999999 5.72311E-12 237.92580687067348 193.5532856873299 231.09332593577741 816.4767388888891 308.647 5.72313E-12 961.2311395578722 838.2990005999682 976.550902258094 344.675;5.72311E-12;94.1074;61.543;728.316;14.7631;131.7;42.4612;104.19;18.1872;212.603;935.649;986.476;234.759;119.401;22.9134;760.927;766.819 244.2;5.72311E-12;37.7692;25.6719;443.137;9.42992;39.9158;20.6424;38.4229;10.0176;119.81;808.484;552.974;129.148;81.8286;11.4115;413.607;421.048 560.435;5.72313E-12;148.485;148.788;2039.06;25.7196;397.209;98.0534;163.044;36.7271;1510.69;1071.05;2230.86;694.216;220.085;50.1592;2639.93;2662.07 3 15 3 24426;312495;29397 GSTP1_8762;CYP26B1_8418;CCL11_33230 339.80876666666666 18.1872 560.0328687813274 190.80717333333337 10.0176 313.6458099437934 764.4355666666667 36.7271 1269.9727380033805 14.7631;18.1872;986.476 9.42992;10.0176;552.974 25.7196;36.7271;2230.86 15 688621;24832;25682;338475;81687;25283;24367;29243;84032;24854;24232;246142;29657;29221;81639 TSLP_32811;THY1_33010;PPARD_9536;NREP_9364;MMP9_32531;GCLC_8699;FGG_8639;F10_8585;COL3A1_8354;CLU_32773;C3_8175;BMF_8152;ARNTL_8086;ARG1_33267;ALOX15_8036 304.00426666666704 131.7 323.2830535612815 189.00642000000036 81.8286 233.8485816267841 826.8849733333337 397.209 943.8522444377003 344.675;5.72311E-12;94.1074;61.543;728.316;131.7;42.4612;104.19;212.603;935.649;234.759;119.401;22.9134;760.927;766.819 244.2;5.72311E-12;37.7692;25.6719;443.137;39.9158;20.6424;38.4229;119.81;808.484;129.148;81.8286;11.4115;413.607;421.048 560.435;5.72313E-12;148.485;148.788;2039.06;397.209;98.0534;163.044;1510.69;1071.05;694.216;220.085;50.1592;2639.93;2662.07 0 Exp 2,3(0.17);Exp 4,5(0.28);Exp 5,2(0.12);Hill,2(0.12);Linear,1(0.06);Poly 2,4(0.23);Power,1(0.06) 1.9272279219829291 36.01725888252258 1.5021449327468872 3.5281898975372314 0.627211293886465 1.8247878551483154 147.84782096069767 472.0955457059695 79.39043060330026 299.22266050781144 372.4106082704471 1260.5428695073315 DOWN 0.16666666666666666 0.8333333333333334 0.0 GO:0030856 6 regulation of epithelial cell differentiation 50 51 5 4 4 3 3 3 65 48 2431 0.95467 0.1536 0.1536 5.88 81687;29657;170913 mmp9;arntl;abcb1a MMP9_32531;ARNTL_8086;ABCB1A_7938 319.4038 206.982 22.9134 365.892337796407 435.61197167292454 341.2961008098464 190.85783333333333 118.025 11.4115 224.88929064338154 261.27802270198856 211.6261746856732 1206.9230666666665 1531.55 50.1592 1033.4256540478434 1646.4607293005145 658.0607295290556 1.5 467.649 728.316;22.9134;206.982 443.137;11.4115;118.025 2039.06;50.1592;1531.55 0 3 0 3 81687;29657;170913 MMP9_32531;ARNTL_8086;ABCB1A_7938 319.4038 206.982 365.892337796407 190.85783333333333 118.025 224.88929064338154 1206.9230666666665 1531.55 1033.4256540478434 728.316;22.9134;206.982 443.137;11.4115;118.025 2039.06;50.1592;1531.55 0 Exp 4,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 2.371109787741938 7.381802320480347 1.8874764442443848 3.442979335784912 0.854701165229741 2.05134654045105 -94.64235785350701 733.4499578535072 -63.62835594867448 445.34402261534115 37.491850744771 2376.3542825885625 DOWN 0.0 1.0 0.0 GO:1904446 8 positive regulation of establishment of Sertoli cell barrier 1 1 1 1 1 1 1 1 67 0 2479 1.0 0.026698 0.026698 100.0 170913 abcb1a ABCB1A_7938 206.982 206.982 206.982 206.982 118.025 118.025 118.025 118.025 1531.55 1531.55 1531.55 1531.55 0.0 206.982 0.0 206.982 206.982 118.025 1531.55 0 1 0 1 170913 ABCB1A_7938 206.982 206.982 118.025 118.025 1531.55 1531.55 206.982 118.025 1531.55 0 Poly 2,1(1) 1.8874764442443848 1.8874764442443848 1.8874764442443848 1.8874764442443848 0.0 1.8874764442443848 206.982 206.982 118.025 118.025 1531.55 1531.55 DOWN 0.0 1.0 0.0 GO:2001225 8 regulation of chloride transport 1 1 1 1 1 1 1 1 67 0 2479 1.0 0.026698 0.026698 100.0 170913 abcb1a ABCB1A_7938 206.982 206.982 206.982 206.982 118.025 118.025 118.025 118.025 1531.55 1531.55 1531.55 1531.55 0.0 206.982 0.0 206.982 206.982 118.025 1531.55 0 1 0 1 170913 ABCB1A_7938 206.982 206.982 118.025 118.025 1531.55 1531.55 206.982 118.025 1531.55 0 Poly 2,1(1) 1.8874764442443848 1.8874764442443848 1.8874764442443848 1.8874764442443848 0.0 1.8874764442443848 206.982 206.982 118.025 118.025 1531.55 1531.55 DOWN 0.0 1.0 0.0 GO:0019184 7 nonribosomal peptide biosynthetic process 3 3 2 2 2 2 2 2 66 1 2478 0.99998 0.0020713 0.0020713 66.67 156275;25283 ggt7;gclc GGT7_33026;GCLC_8699 120.65449999999998 120.65449999999998 109.609 15.620695903192185 125.05158255022681 14.32960120146356 34.6247 34.6247 29.3336 7.482745379872284 36.731024157485415 6.8642753082307495 371.64099999999996 371.64099999999996 346.073 36.15861236275655 381.81931756318863 33.170000771264334 0.0 109.609 0.0 109.609 109.609;131.7 29.3336;39.9158 346.073;397.209 0 2 0 2 156275;25283 GGT7_33026;GCLC_8699 120.65449999999998 120.65449999999998 15.620695903192185 34.6247 34.6247 7.482745379872284 371.64099999999996 371.64099999999996 36.15861236275655 109.609;131.7 29.3336;39.9158 346.073;397.209 0 Exp 4,1(0.5);Hill,1(0.5) 1.9526141222274978 3.9054750204086304 1.930785894393921 1.9746891260147095 0.03104427279506326 1.9527375102043152 99.00532 142.30367999999999 24.254144000000004 44.99525599999999 321.52771999999993 421.75428 DOWN 0.0 1.0 0.0 GO:0033189 6 response to vitamin A 20 20 7 7 7 7 7 7 61 13 2466 1.0 4.1672E-7 4.1672E-7 35.0 25682;81687;312495;24296;29221;24646;170913 ppard;mmp9;cyp26b1;cyp1a1;arg1;abcb1b;abcb1a PPARD_9536;MMP9_32531;CYP26B1_8418;CYP1A1_8415;ARG1_33267;ABCB1B_7939;ABCB1A_7938 263.17142857142863 94.1074 12.8863 335.97288236200814 261.97128806400156 336.2939558394196 148.5629585714286 37.7692 8.25355 195.17203984689172 149.03825542417678 196.59621605735913 924.6124285714286 148.485 19.3234 1119.1758659938075 929.7129282887687 1103.9418388828274 0.0 12.8863 1.0 18.1872 94.1074;728.316;18.1872;12.8863;760.927;20.7941;206.982 37.7692;443.137;10.0176;9.13136;413.607;8.25355;118.025 148.485;2039.06;36.7271;19.3234;2639.93;57.2115;1531.55 2 5 2 312495;24296 CYP26B1_8418;CYP1A1_8415 15.536750000000001 15.536750000000001 3.7483023363917627 9.574480000000001 9.574480000000001 0.6266663137587598 28.02525 28.02525 12.306274287736318 18.1872;12.8863 10.0176;9.13136 36.7271;19.3234 5 25682;81687;29221;24646;170913 PPARD_9536;MMP9_32531;ARG1_33267;ABCB1B_7939;ABCB1A_7938 362.22530000000006 206.982 355.5096345523282 204.15835 118.025 208.84355749318073 1283.2472999999998 1531.55 1147.2079450965723 94.1074;728.316;760.927;20.7941;206.982 37.7692;443.137;413.607;8.25355;118.025 148.485;2039.06;2639.93;57.2115;1531.55 0 Exp 2,1(0.15);Exp 4,2(0.29);Exp 5,1(0.15);Hill,1(0.15);Linear,1(0.15);Poly 2,1(0.15) 3.01741396352434 31.15989649295807 1.513624906539917 15.48720932006836 5.12619231217864 2.05134654045105 14.279234253827553 512.0636228890296 3.97748808517062 293.1484290576866 95.51534443723847 1753.7095127056186 DOWN 0.2857142857142857 0.7142857142857143 0.0 GO:0043207 4 response to external biotic stimulus 357 390 34 34 23 23 17 17 51 373 2106 0.98878 0.023715 0.038225 4.36 116669;688621;295703;25682;362282;304545;81687;362376;24426;24296;245920;24854;29397;24232;29221;24646;170913 vwf;tslp;serping1;ppard;pck1;oasl;mmp9;herc6;gstp1;cyp1a1;cxcl10;clu;ccl11;c3;arg1;abcb1b;abcb1a VWF_32396;TSLP_32811;SERPING1_32597;PPARD_9536;PCK1_9439;OASL_9389;MMP9_32531;HERC6_8794;GSTP1_8762;CYP1A1_8415;CXCL10_8408;CLU_32773;CCL11_33230;C3_8175;ARG1_33267;ABCB1B_7939;ABCB1A_7938 335.79306470588233 206.982 12.8863 354.0987292895214 311.256717739126 357.50752958015613 209.87716882352944 118.025 4.11644 242.26274067683823 193.09760846201135 239.43869860215315 859.1507647058825 560.435 19.3234 896.0892128935277 839.1895989190018 932.684756886347 19.6764;344.675;32.3997;94.1074;529.244;76.6126;728.316;39.6865;14.7631;12.8863;670.528;935.649;986.476;234.759;760.927;20.7941;206.982 4.11644;244.2;13.7308;37.7692;356.883;28.4477;443.137;15.7729;9.42992;9.13136;374.802;808.484;552.974;129.148;413.607;8.25355;118.025 94.078;560.435;99.4885;148.485;1021.06;260.389;2039.06;157.407;25.7196;19.3234;1955.3;1071.05;2230.86;694.216;2639.93;57.2115;1531.55 4 13 4 362282;24426;24296;29397 PCK1_9439;GSTP1_8762;CYP1A1_8415;CCL11_33230 385.84235 272.00355 468.3733694917656 232.10457000000002 183.15645999999998 269.46112881831175 824.2407499999999 523.3897999999999 1049.2606125218956 529.244;14.7631;12.8863;986.476 356.883;9.42992;9.13136;552.974 1021.06;25.7196;19.3234;2230.86 13 116669;688621;295703;25682;304545;81687;362376;245920;24854;24232;29221;24646;170913 VWF_32396;TSLP_32811;SERPING1_32597;PPARD_9536;OASL_9389;MMP9_32531;HERC6_8794;CXCL10_8408;CLU_32773;C3_8175;ARG1_33267;ABCB1B_7939;ABCB1A_7938 320.3932846153847 206.982 333.53548109876016 203.03796846153847 118.025 244.71881286471816 869.8923076923077 560.435 891.5527538259336 19.6764;344.675;32.3997;94.1074;76.6126;728.316;39.6865;670.528;935.649;234.759;760.927;20.7941;206.982 4.11644;244.2;13.7308;37.7692;28.4477;443.137;15.7729;374.802;808.484;129.148;413.607;8.25355;118.025 94.078;560.435;99.4885;148.485;260.389;2039.06;157.407;1955.3;1071.05;694.216;2639.93;57.2115;1531.55 0 Exp 2,3(0.18);Exp 4,5(0.3);Exp 5,1(0.06);Hill,2(0.12);Linear,2(0.12);Poly 2,3(0.18);Power,1(0.06) 2.268442348147911 50.311681628227234 1.513624906539917 15.48720932006836 3.4208256583991825 1.8874764442443848 167.46521370558398 504.12091570618077 94.71277216670825 325.0415654803505 433.1769923244854 1285.1245370872794 DOWN 0.23529411764705882 0.7647058823529411 0.0 GO:0080090 5 regulation of primary metabolic process 955 1029 58 55 36 34 26 26 42 1003 1476 0.40668 0.68716 0.80247 2.53 688621;360243;24832;25671;295703;25682;363131;25154;362282;304545;259241;316351;81687;24426;25283;24367;361921;64191;24854;306575;113902;114494;29397;24232;29657;81639 tslp;top2a;thy1;smad1;serping1;ppard;pik3r4;pgr;pck1;oasl;nr1d2;npas2;mmp9;gstp1;gclc;fgg;ect2;dhcr7;clu;ckap2;ces1d;ccna2;ccl11;c3;arntl;alox15 TSLP_32811;TOP2A_10059;THY1_33010;SMAD1_32578;SERPING1_32597;PPARD_9536;PIK3R4_9484;PGR_32824;PCK1_9439;OASL_9389;NR1D2_9358;NPAS2_9350;MMP9_32531;GSTP1_8762;GCLC_8699;FGG_8639;ECT2_8523;DHCR7_8466;CLU_32773;CKAP2_8324;CES1D_32914;CCNA2_8221;CCL11_33230;C3_8175;ARNTL_8086;ALOX15_8036 252.62295384615405 81.50045 5.72311E-12 336.33040669372616 240.3654628844399 321.4928099583532 158.3116353846156 27.56825 5.72311E-12 241.10975798143298 142.78308569367164 222.6036289664194 591.2582192307694 204.437 5.72313E-12 769.3607873520338 590.8706081005874 787.3712405829839 344.675;86.3883;5.72311E-12;21.9973;32.3997;94.1074;955.628;283.618;529.244;76.6126;29.1728;21.0878;728.316;14.7631;131.7;42.4612;10.0162;161.702;935.649;32.2386;11.0684;14.384;986.476;234.759;22.9134;766.819 244.2;26.6888;5.72311E-12;5.02186;13.7308;37.7692;735.228;138.711;356.883;28.4477;3.35457;11.3305;443.137;9.42992;39.9158;20.6424;3.29405;50.9087;808.484;15.2683;4.18343;4.89199;552.974;129.148;11.4115;421.048 560.435;262.273;5.72313E-12;80.1461;99.4885;148.485;1288.97;1554.21;1021.06;260.389;114.038;43.5624;2039.06;25.7196;397.209;98.0534;37.7305;481.517;1071.05;76.7052;17.0564;58.2504;2230.86;694.216;50.1592;2662.07 4 22 4 362282;259241;24426;29397 PCK1_9439;NR1D2_9358;GSTP1_8762;CCL11_33230 389.913975 279.20840000000004 464.1018135036922 230.6603725 183.15645999999998 271.06522408744866 847.9194 567.549 1025.8487203096306 529.244;29.1728;14.7631;986.476 356.883;3.35457;9.42992;552.974 1021.06;114.038;25.7196;2230.86 22 688621;360243;24832;25671;295703;25682;363131;25154;304545;316351;81687;25283;24367;361921;64191;24854;306575;113902;114494;24232;29657;81639 TSLP_32811;TOP2A_10059;THY1_33010;SMAD1_32578;SERPING1_32597;PPARD_9536;PIK3R4_9484;PGR_32824;OASL_9389;NPAS2_9350;MMP9_32531;GCLC_8699;FGG_8639;ECT2_8523;DHCR7_8466;CLU_32773;CKAP2_8324;CES1D_32914;CCNA2_8221;C3_8175;ARNTL_8086;ALOX15_8036 227.66095000000024 81.50045 315.67603554961306 145.15731954545478 27.56825 239.8585561489272 544.5925500000002 204.437 734.5032278794116 344.675;86.3883;5.72311E-12;21.9973;32.3997;94.1074;955.628;283.618;76.6126;21.0878;728.316;131.7;42.4612;10.0162;161.702;935.649;32.2386;11.0684;14.384;234.759;22.9134;766.819 244.2;26.6888;5.72311E-12;5.02186;13.7308;37.7692;735.228;138.711;28.4477;11.3305;443.137;39.9158;20.6424;3.29405;50.9087;808.484;15.2683;4.18343;4.89199;129.148;11.4115;421.048 560.435;262.273;5.72313E-12;80.1461;99.4885;148.485;1288.97;1554.21;260.389;43.5624;2039.06;397.209;98.0534;37.7305;481.517;1071.05;76.7052;17.0564;58.2504;694.216;50.1592;2662.07 0 Exp 2,2(0.08);Exp 4,13(0.5);Exp 5,2(0.08);Hill,2(0.08);Linear,2(0.08);Poly 2,4(0.16);Power,1(0.04) 1.9288411728647963 51.81398630142212 1.5018656253814697 3.5281898975372314 0.577040059826076 1.8280008435249329 123.34170764530876 381.9042000469994 65.63202818094935 250.99124258828186 295.52545351176127 886.9909849497776 DOWN 0.15384615384615385 0.8461538461538461 0.0 GO:0071375 6 cellular response to peptide hormone stimulus 102 109 10 10 6 9 6 6 62 103 2376 0.97566 0.068126 0.068126 5.5 25154;362282;24426;25283;114494;29221 pgr;pck1;gstp1;gclc;ccna2;arg1 PGR_32824;PCK1_9439;GSTP1_8762;GCLC_8699;CCNA2_8221;ARG1_33267 289.1060166666667 207.659 14.384 301.9351871277703 250.47590093903827 308.39760625519546 160.57311833333333 89.3134 4.89199 181.4831869448311 127.12120518402119 177.56991436060417 949.3965 709.1345 25.7196 1017.9459675181016 862.3120591366907 1080.3674717121512 4.5 645.0855 283.618;529.244;14.7631;131.7;14.384;760.927 138.711;356.883;9.42992;39.9158;4.89199;413.607 1554.21;1021.06;25.7196;397.209;58.2504;2639.93 2 4 2 362282;24426 PCK1_9439;GSTP1_8762 272.00355 272.00355 363.7929331809581 183.15645999999998 183.15645999999998 245.686429012152 523.3897999999999 523.3897999999999 703.8119464289307 529.244;14.7631 356.883;9.42992 1021.06;25.7196 4 25154;25283;114494;29221 PGR_32824;GCLC_8699;CCNA2_8221;ARG1_33267 297.65725 207.659 327.9235199446918 149.2814475 89.3134 185.10257728713475 1162.39985 975.7095 1174.9146894790658 283.618;131.7;14.384;760.927 138.711;39.9158;4.89199;413.607 1554.21;397.209;58.2504;2639.93 0 Exp 2,1(0.17);Exp 4,2(0.34);Hill,1(0.17);Linear,1(0.17);Poly 2,1(0.17) 1.8687408972455959 11.795297741889954 1.513624906539917 3.5281898975372314 0.7831890048384403 1.6191038489341736 47.507549674101 530.7044836592323 15.356324729737878 305.7899119369288 134.87008599325793 1763.9229140067423 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0048729 4 tissue morphogenesis 105 109 6 6 4 5 3 3 65 106 2373 0.66827 0.56373 0.76612 2.75 288583;84032;29397 plod3;col3a1;ccl11 PLOD3_9507;COL3A1_8354;CCL11_33230 693.9026666666667 882.629 212.603 420.039375180867 750.0209747596153 413.04961819909397 432.8203333333334 552.974 119.81 273.50143168241965 445.6955972465035 251.02512774103695 1615.8566666666666 1510.69 1106.02 569.7466781240013 1813.7572104458043 566.1026049594778 882.629;212.603;986.476 625.677;119.81;552.974 1106.02;1510.69;2230.86 1 2 1 29397 CCL11_33230 986.476 986.476 552.974 552.974 2230.86 2230.86 986.476 552.974 2230.86 2 288583;84032 PLOD3_9507;COL3A1_8354 547.616 547.616 473.77992817129774 372.74350000000004 372.74350000000004 357.7019860784952 1308.355 1308.355 286.14490114276066 882.629;212.603 625.677;119.81 1106.02;1510.69 0 Poly 2,2(0.67);Power,1(0.34) 1.7635381878280978 5.310533165931702 1.6129854917526245 1.9814788103103638 0.1901122243565097 1.7160688638687134 218.58336785807143 1169.2219654752619 123.32432793037088 742.3163387362958 971.1276066164847 2260.585726716849 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0007154 3 cell communication 162 169 22 22 15 14 10 10 58 159 2320 0.99562 0.012743 0.012743 5.92 24832;363131;25154;362282;81687;24426;170945;246142;25612;170913 thy1;pik3r4;pgr;pck1;mmp9;gstp1;chrna2;bmf;asns;abcb1a THY1_33010;PIK3R4_9484;PGR_32824;PCK1_9439;MMP9_32531;GSTP1_8762;CHRNA2_32401;BMF_8152;ASNS_8091;ABCB1A_7938 319.2576100000006 199.0635 5.72311E-12 317.19799757380514 270.7572117258781 270.55841849538683 209.87745200000055 115.7945 5.72311E-12 232.63237099123708 170.23847443262605 183.64393550839551 860.5283600000006 765.6635 5.72313E-12 722.577454090506 831.0226902837927 747.3122339550054 7.5 628.78 5.72311E-12;955.628;283.618;529.244;728.316;14.7631;163.479;119.401;191.145;206.982 5.72311E-12;735.228;138.711;356.883;443.137;9.42992;101.968;81.8286;113.564;118.025 5.72313E-12;1288.97;1554.21;1021.06;2039.06;25.7196;414.362;220.085;510.267;1531.55 2 8 2 362282;24426 PCK1_9439;GSTP1_8762 272.00355 272.00355 363.7929331809581 183.15645999999998 183.15645999999998 245.686429012152 523.3897999999999 523.3897999999999 703.8119464289307 529.244;14.7631 356.883;9.42992 1021.06;25.7196 8 24832;363131;25154;81687;170945;246142;25612;170913 THY1_33010;PIK3R4_9484;PGR_32824;MMP9_32531;CHRNA2_32401;BMF_8152;ASNS_8091;ABCB1A_7938 331.07112500000073 199.0635 331.14594609042774 216.5577000000007 115.7945 246.3776225815734 944.8130000000008 899.6185 748.2891264082723 5.72311E-12;955.628;283.618;728.316;163.479;119.401;191.145;206.982 5.72311E-12;735.228;138.711;443.137;101.968;81.8286;113.564;118.025 5.72313E-12;1288.97;1554.21;2039.06;414.362;220.085;510.267;1531.55 0 Exp 4,1(0.1);Hill,1(0.1);Linear,2(0.2);Poly 2,6(0.6) 1.859433339995001 19.19148075580597 1.5018656253814697 3.5281898975372314 0.5916016409102447 1.8020069003105164 122.65625425075419 515.8589657492471 65.69041463575269 354.0644893642485 412.67021400089766 1308.3865059991033 DOWN 0.2 0.8 0.0 GO:0046173 6 polyol biosynthetic process 14 16 2 2 2 2 2 2 66 14 2465 0.99205 0.066251 0.066251 12.5 362282;25315 pck1;ephx1 PCK1_9439;EPHX1_8567 284.24105000000003 284.24105000000003 39.2381 346.48649471141727 150.6990635750422 290.49262768744705 187.92085 187.92085 18.9587 238.94856405771722 95.82587260633314 200.3333385709053 551.37825 551.37825 81.6965 664.2303008491293 295.37221463368934 556.887522106728 0.0 39.2381 0.5 284.24105000000003 529.244;39.2381 356.883;18.9587 1021.06;81.6965 2 0 2 362282;25315 PCK1_9439;EPHX1_8567 284.24105000000003 284.24105000000003 346.48649471141727 187.92085 187.92085 238.94856405771722 551.37825 551.37825 664.2303008491293 529.244;39.2381 356.883;18.9587 1021.06;81.6965 0 0 Exp 4,1(0.5);Linear,1(0.5) 1.8168294256293827 3.6598446369171143 1.611412525177002 2.0484321117401123 0.3090195131701167 1.8299223184585571 -195.9647319999999 764.446832 -143.24496399999995 519.0866639999999 -369.1979799999998 1471.9544799999999 UP 1.0 0.0 0.0 GO:0048513 4 animal organ development 418 452 37 35 21 25 18 18 50 434 2045 0.97645 0.045114 0.074607 3.98 116669;360243;25671;25682;25154;81687;291234;24426;25315;64191;312495;24296;84032;114494;25612;29221;24646;170913 vwf;top2a;smad1;ppard;pgr;mmp9;mki67;gstp1;ephx1;dhcr7;cyp26b1;cyp1a1;col3a1;ccna2;asns;arg1;abcb1b;abcb1a VWF_32396;TOP2A_10059;SMAD1_32578;PPARD_9536;PGR_32824;MMP9_32531;MKI67_9232;GSTP1_8762;EPHX1_8567;DHCR7_8466;CYP26B1_8418;CYP1A1_8415;COL3A1_8354;CCNA2_8221;ASNS_8091;ARG1_33267;ABCB1B_7939;ABCB1A_7938 161.64701666666667 62.8132 12.8863 228.91663159318185 164.79850244960423 234.87220828071582 85.49270333333332 22.82375 4.11644 133.249959318347 86.63078640231478 138.40811263416512 622.6285555555555 121.28150000000001 19.3234 833.5702250277842 593.5806054485197 813.0692286249013 19.6764;86.3883;21.9973;94.1074;283.618;728.316;21.9311;14.7631;39.2381;161.702;18.1872;12.8863;212.603;14.384;191.145;760.927;20.7941;206.982 4.11644;26.6888;5.02186;37.7692;138.711;443.137;6.82654;9.42992;18.9587;50.9087;10.0176;9.13136;119.81;4.89199;113.564;413.607;8.25355;118.025 94.078;262.273;80.1461;148.485;1554.21;2039.06;76.1794;25.7196;81.6965;481.517;36.7271;19.3234;1510.69;58.2504;510.267;2639.93;57.2115;1531.55 4 14 4 24426;25315;312495;24296 GSTP1_8762;EPHX1_8567;CYP26B1_8418;CYP1A1_8415 21.268675 16.47515 12.178976964801548 11.884395 9.723759999999999 4.7305519072619875 40.86665 31.22335 28.152899610815698 14.7631;39.2381;18.1872;12.8863 9.42992;18.9587;10.0176;9.13136 25.7196;81.6965;36.7271;19.3234 14 116669;360243;25671;25682;25154;81687;291234;64191;84032;114494;25612;29221;24646;170913 VWF_32396;TOP2A_10059;SMAD1_32578;PPARD_9536;PGR_32824;MMP9_32531;MKI67_9232;DHCR7_8466;COL3A1_8354;CCNA2_8221;ASNS_8091;ARG1_33267;ABCB1B_7939;ABCB1A_7938 201.75511428571426 127.90469999999999 246.36706216206014 106.52364857142857 44.33895 145.15569953527313 788.8462428571429 371.895 880.0920647033885 19.6764;86.3883;21.9973;94.1074;283.618;728.316;21.9311;161.702;212.603;14.384;191.145;760.927;20.7941;206.982 4.11644;26.6888;5.02186;37.7692;138.711;443.137;6.82654;50.9087;119.81;4.89199;113.564;413.607;8.25355;118.025 94.078;262.273;80.1461;148.485;1554.21;2039.06;76.1794;481.517;1510.69;58.2504;510.267;2639.93;57.2115;1531.55 0 Exp 2,1(0.06);Exp 4,9(0.5);Exp 5,1(0.06);Hill,2(0.12);Linear,1(0.06);Poly 2,4(0.23) 2.284542540181963 52.78194439411163 1.513624906539917 15.48720932006836 3.3176490783604384 1.9304704070091248 55.89292834973129 267.4011049836021 23.93436277980129 147.0510438868654 237.53875853015853 1007.7183525809528 DOWN 0.2222222222222222 0.7777777777777778 0.0 GO:0032436 11 positive regulation of proteasomal ubiquitin-dependent protein catabolic process 29 29 4 4 4 2 2 2 66 27 2452 0.95947 0.18033 0.18033 6.9 25283;24854 gclc;clu GCLC_8699;CLU_32773 533.6745 533.6745 131.7 568.4777896281438 381.90730771072793 526.403301651654 424.1999 424.1999 39.9158 543.4597860243388 279.1117939176245 503.2369441649518 734.1295 734.1295 397.209 476.4775405415244 606.923723738825 441.2122251389729 0.5 533.6745 131.7;935.649 39.9158;808.484 397.209;1071.05 0 2 0 2 25283;24854 GCLC_8699;CLU_32773 533.6745 533.6745 568.4777896281438 424.1999 424.1999 543.4597860243388 734.1295 734.1295 476.4775405415244 131.7;935.649 39.9158;808.484 397.209;1071.05 0 Hill,1(0.5);Poly 2,1(0.5) 1.7522452006081033 3.529548168182373 1.5548590421676636 1.9746891260147095 0.296864699234363 1.7647740840911865 -254.19552 1321.5445200000001 -328.99693599999995 1177.396736 73.7653200000002 1394.4936799999998 DOWN 0.0 1.0 0.0 GO:1904709 10 negative regulation of granulosa cell apoptotic process 1 1 1 1 1 1 1 1 67 0 2479 1.0 0.026698 0.026698 100.0 25154 pgr PGR_32824 283.618 283.618 283.618 283.618 138.711 138.711 138.711 138.711 1554.21 1554.21 1554.21 1554.21 0.0 283.618 0.0 283.618 283.618 138.711 1554.21 0 1 0 1 25154 PGR_32824 283.618 283.618 138.711 138.711 1554.21 1554.21 283.618 138.711 1554.21 0 Poly 2,1(1) 1.5405861139297485 1.5405861139297485 1.5405861139297485 1.5405861139297485 0.0 1.5405861139297485 283.618 283.618 138.711 138.711 1554.21 1554.21 DOWN 0.0 1.0 0.0 GO:0070372 8 regulation of ERK1 and ERK2 cascade 108 115 12 12 7 7 5 5 63 110 2369 0.91633 0.1906 0.23199 4.35 24426;24367;29397;24232;81639 gstp1;fgg;ccl11;c3;alox15 GSTP1_8762;FGG_8639;CCL11_33230;C3_8175;ALOX15_8036 409.05566 234.759 14.7631 442.0538154893791 426.8428843478261 457.5345857063195 226.64846400000002 129.148 9.42992 246.6821182134864 236.2201297965038 255.63980510031683 1142.1838 694.216 25.7196 1228.0722374233042 1191.0539692424923 1278.6292716533485 14.7631;42.4612;986.476;234.759;766.819 9.42992;20.6424;552.974;129.148;421.048 25.7196;98.0534;2230.86;694.216;2662.07 2 3 2 24426;29397 GSTP1_8762;CCL11_33230 500.61955 500.61955 687.1047809564456 281.20196000000004 281.20196000000004 384.3437048418033 1128.2898 1128.2898 1559.2697303084162 14.7631;986.476 9.42992;552.974 25.7196;2230.86 3 24367;24232;81639 FGG_8639;C3_8175;ALOX15_8036 348.01306666666665 234.759 375.2244905621344 190.27946666666665 129.148 207.08441102713002 1151.4464666666668 694.216 1341.7675119054916 42.4612;234.759;766.819 20.6424;129.148;421.048 98.0534;694.216;2662.07 0 Exp 2,1(0.2);Exp 4,2(0.4);Poly 2,1(0.2);Power,1(0.2) 2.1483861622462315 11.376213073730469 1.5021449327468872 3.5281898975372314 0.8773158042708317 1.9814788103103638 21.57840659021872 796.5329134097811 10.42205381767414 442.8748741823259 65.73102236976251 2218.6365776302373 DOWN 0.4 0.6 0.0 GO:0010558 7 negative regulation of macromolecule biosynthetic process 265 277 15 12 10 7 6 6 62 271 2208 0.37874 0.7661 0.69602 2.17 25682;25154;259241;24426;25283;29657 ppard;pgr;nr1d2;gstp1;gclc;arntl PPARD_9536;PGR_32824;NR1D2_9358;GSTP1_8762;GCLC_8699;ARNTL_8086 96.04578333333332 61.6401 14.7631 102.8450610997809 100.67447400472334 84.60349713644486 40.098665000000004 24.59035 3.35457 50.68235656306433 37.23927478323212 40.823309466877056 381.6368 131.2615 25.7196 589.5241699766617 352.81930409075574 467.96207960887097 94.1074;283.618;29.1728;14.7631;131.7;22.9134 37.7692;138.711;3.35457;9.42992;39.9158;11.4115 148.485;1554.21;114.038;25.7196;397.209;50.1592 2 4 2 259241;24426 NR1D2_9358;GSTP1_8762 21.96795 21.96795 10.18919658486379 6.392244999999999 6.392244999999999 4.295921183081692 69.8788 69.8788 62.45053954354597 29.1728;14.7631 3.35457;9.42992 114.038;25.7196 4 25682;25154;25283;29657 PPARD_9536;PGR_32824;GCLC_8699;ARNTL_8086 133.0847 112.90369999999999 110.02899172787748 56.951875 38.8425 56.02583674064286 537.5158 272.847 693.3528474862998 94.1074;283.618;131.7;22.9134 37.7692;138.711;39.9158;11.4115 148.485;1554.21;397.209;50.1592 0 Exp 4,3(0.5);Exp 5,1(0.17);Hill,1(0.17);Poly 2,1(0.17) 2.3210937141827768 14.607720494270325 1.5405861139297485 3.5281898975372314 0.8405810397348662 2.0785329937934875 13.752595395124601 178.33897127154205 -0.4556664301598943 80.65299643015989 -90.08077977699588 853.3543797769959 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0001954 8 positive regulation of cell-matrix adhesion 19 20 3 3 2 3 2 2 66 18 2461 0.98501 0.098041 0.098041 10.0 24832;81919 thy1;fut1 THY1_33010;FUT1_8668 120.43050000000285 120.43050000000285 5.72311E-12 170.31444642336896 169.41325937966954 155.59045352336358 39.48630000000286 39.48630000000286 5.72311E-12 55.8420609879287 55.54658316492569 51.014413499564434 423.93500000000284 423.93500000000284 5.72313E-12 599.5346265646341 596.3623012037623 547.7037703441262 0.0 5.72311E-12 1.0 240.861 5.72311E-12;240.861 5.72311E-12;78.9726 5.72313E-12;847.87 0 2 0 2 24832;81919 THY1_33010;FUT1_8668 120.43050000000285 120.43050000000285 170.31444642336896 39.48630000000286 39.48630000000286 55.8420609879287 423.93500000000284 423.93500000000284 599.5346265646341 5.72311E-12;240.861 5.72311E-12;78.9726 5.72313E-12;847.87 0 Exp 2,1(0.5);Hill,1(0.5) 2.258230573967288 4.600212574005127 1.863204002380371 2.737008571624756 0.6178731363444946 2.3001062870025635 -115.6132799999915 356.47427999999724 -37.90684799999151 116.87944799999723 -406.97759999999164 1254.8475999999973 DOWN 0.0 1.0 0.0 GO:0006635 7 fatty acid beta-oxidation 29 33 2 2 2 2 2 2 66 31 2448 0.94386 0.21961 0.21961 6.06 25682;252898 ppard;acox2 PPARD_9536;ACOX2_32902 418.73019999999997 418.73019999999997 94.1074 459.0859664155287 375.9187068807339 455.0761218449921 235.1531 235.1531 37.7692 279.1429883740947 209.12196639908257 276.70483936014267 1218.1375 1218.1375 148.485 1512.717072526287 1077.0709432339452 1499.5043830002091 0.5 418.73019999999997 94.1074;743.353 37.7692;432.537 148.485;2287.79 0 2 0 2 25682;252898 PPARD_9536;ACOX2_32902 418.73019999999997 418.73019999999997 459.0859664155287 235.1531 235.1531 279.1429883740947 1218.1375 1218.1375 1512.717072526287 94.1074;743.353 37.7692;432.537 148.485;2287.79 0 Exp 2,1(0.5);Exp 5,1(0.5) 1.7234640195955295 3.470865488052368 1.5319663286209106 1.9388991594314575 0.28774496415357576 1.735432744026184 -217.530488 1054.9908879999998 -151.71934399999992 622.0255439999999 -878.3813999999998 3314.6563999999994 DOWN 0.0 1.0 0.0 GO:0030155 5 regulation of cell adhesion 210 219 15 14 8 9 6 6 62 213 2266 0.63267 0.53748 0.8284 2.74 24832;81919;24367;309186;29221;81639 thy1;fut1;fgg;fermt3;arg1;alox15 THY1_33010;FUT1_8668;FGG_8639;FERMT3_32542;ARG1_33267;ALOX15_8036 391.69686666666763 389.987 5.72311E-12 345.52061227849447 372.5424253498984 337.74536052683186 211.4196666666676 206.6103 5.72311E-12 199.27218660156808 193.7749586727479 195.88944634774828 1239.2972333333344 1017.865 5.72313E-12 1181.54227010849 1215.4254564239666 1163.4549050596681 5.72311E-12;240.861;42.4612;539.113;760.927;766.819 5.72311E-12;78.9726;20.6424;334.248;413.607;421.048 5.72313E-12;847.87;98.0534;1187.86;2639.93;2662.07 0 6 0 6 24832;81919;24367;309186;29221;81639 THY1_33010;FUT1_8668;FGG_8639;FERMT3_32542;ARG1_33267;ALOX15_8036 391.69686666666763 389.987 345.52061227849447 211.4196666666676 206.6103 199.27218660156808 1239.2972333333344 1017.865 1181.54227010849 5.72311E-12;240.861;42.4612;539.113;760.927;766.819 5.72311E-12;78.9726;20.6424;334.248;413.607;421.048 5.72313E-12;847.87;98.0534;1187.86;2639.93;2662.07 0 Exp 2,4(0.67);Exp 4,1(0.17);Hill,1(0.17) 1.9475753533934754 12.103994607925415 1.5021449327468872 2.8176381587982178 0.6036055225673848 1.7667890191078186 115.22279607253125 668.1709372608041 51.968708813178864 370.87062452015635 293.8665140434716 2184.727952623197 DOWN 0.0 1.0 0.0 GO:0032963 3 collagen metabolic process 13 17 5 5 3 4 3 3 65 14 2465 0.99915 0.0094669 0.0094669 17.65 288583;81687;29221 plod3;mmp9;arg1 PLOD3_9507;MMP9_32531;ARG1_33267 790.6239999999999 760.927 728.316 81.32994128240905 760.4981048123685 60.05970078997658 494.14033333333333 443.137 413.607 114.86699366368636 455.02523981998985 81.57279988051023 1928.3366666666668 2039.06 1106.02 772.9260730712426 2151.250996588517 596.2842266327144 0.0 728.316 0.5 744.6215 882.629;728.316;760.927 625.677;443.137;413.607 1106.02;2039.06;2639.93 0 3 0 3 288583;81687;29221 PLOD3_9507;MMP9_32531;ARG1_33267 790.6239999999999 760.927 81.32994128240905 494.14033333333333 443.137 114.86699366368636 1928.3366666666668 2039.06 772.9260730712426 882.629;728.316;760.927 625.677;443.137;413.607 1106.02;2039.06;2639.93 0 Exp 2,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 1.746615608033266 5.28104031085968 1.513624906539917 2.05134654045105 0.27158155062812217 1.7160688638687134 698.5905075545531 882.6574924454469 364.1560934963781 624.1245731702886 1053.6884770179954 2802.9848563153378 DOWN 0.0 1.0 0.0 GO:0071356 7 cellular response to tumor necrosis factor 67 70 7 7 5 5 4 4 64 66 2413 0.96292 0.11471 0.11471 5.71 362282;81687;29397;24646 pck1;mmp9;ccl11;abcb1b PCK1_9439;MMP9_32531;CCL11_33230;ABCB1B_7939 566.207525 628.78 20.7941 408.96081927095304 466.45015208019163 468.6671448489667 340.3118875 400.01 8.25355 235.4679872978857 273.64474742304617 273.73602511235254 1337.047875 1530.06 57.2115 1004.9130347720292 1166.7628498181496 1157.2772885134245 2.5 857.396 529.244;728.316;986.476;20.7941 356.883;443.137;552.974;8.25355 1021.06;2039.06;2230.86;57.2115 2 2 2 362282;29397 PCK1_9439;CCL11_33230 757.86 757.86 323.3118477754875 454.9285 454.9285 138.65727582965147 1625.96 1625.96 855.4577838794855 529.244;986.476 356.883;552.974 1021.06;2230.86 2 81687;24646 MMP9_32531;ABCB1B_7939 374.55505 374.55505 500.29353332799036 225.695275 225.695275 307.5090365208009 1048.13575 1048.13575 1401.3785136343874 728.316;20.7941 443.137;8.25355 2039.06;57.2115 0 Hill,1(0.25);Linear,2(0.5);Power,1(0.25) 2.5234755017565753 11.835243105888367 1.611412525177002 6.191005229949951 2.163425689689457 2.016412675380707 165.4259221144659 966.9891278855339 109.55325994807197 571.070515051928 352.2331009234117 2321.8626490765887 CONFLICT 0.5 0.5 0.0 GO:0032103 6 positive regulation of response to external stimulus 125 131 11 10 6 6 4 4 64 127 2352 0.72998 0.46698 0.77729 3.05 688621;245920;24232;29221 tslp;cxcl10;c3;arg1 TSLP_32811;CXCL10_8408;C3_8175;ARG1_33267 502.72225000000003 507.6015 234.759 252.72626775409913 500.2964862551868 250.20495334518566 290.43925 309.501 129.148 129.66662869933037 296.2803978215768 119.97616743738992 1462.4702499999999 1324.758 560.435 1005.5139333098524 1423.9291706431536 1108.2212280604197 344.675;670.528;234.759;760.927 244.2;374.802;129.148;413.607 560.435;1955.3;694.216;2639.93 0 4 0 4 688621;245920;24232;29221 TSLP_32811;CXCL10_8408;C3_8175;ARG1_33267 502.72225000000003 507.6015 252.72626775409913 290.43925 309.501 129.66662869933037 1462.4702499999999 1324.758 1005.5139333098524 344.675;670.528;234.759;760.927 244.2;374.802;129.148;413.607 560.435;1955.3;694.216;2639.93 0 Exp 2,3(0.75);Poly 2,1(0.25) 1.6446819695039614 6.600053548812866 1.513624906539917 1.8538048267364502 0.15500422482203954 1.6163119077682495 255.05050760098277 750.3939923990173 163.36595387465627 417.51254612534376 477.0665953563447 2447.873904643655 DOWN 0.0 1.0 0.0 GO:0006807 3 nitrogen compound metabolic process 1028 1128 67 67 43 44 32 32 36 1096 1383 0.72326 0.36459 0.7108 2.84 315852;360243;24832;25671;291463;25682;299112;288583;363131;362282;300795;313108;81687;291234;316273;293502;362376;24426;156275;25283;81919;24367;29243;24296;84032;297594;114494;29397;116599;25612;29657;29221 ttk;top2a;thy1;smad1;ppic;ppard;pole2;plod3;pik3r4;pck1;pclaf;mms22l;mmp9;mki67;mcm3;kif22;herc6;gstp1;ggt7;gclc;fut1;fgg;f10;cyp1a1;col3a1;cdca3;ccna2;ccl11;blvra;asns;arntl;arg1 TTK_32727;TOP2A_10059;THY1_33010;SMAD1_32578;PPIC_9541;PPARD_9536;POLE2_9520;PLOD3_9507;PIK3R4_9484;PCK1_9439;NS5ATP9_9367;MMS22L_33129;MMP9_32531;MKI67_9232;MCM3_9207;KIF22_8963;HERC6_8794;GSTP1_8762;GGT7_33026;GCLC_8699;FUT1_8668;FGG_8639;F10_8585;CYP1A1_8415;COL3A1_8354;CDCA3_8260;CCNA2_8221;CCL11_33230;BLVRA_8151;ASNS_8091;ARNTL_8086;ARG1_33267 271.1554531334876 118.131 5.72311E-12 319.2586886957875 223.73976958412007 291.0531827171176 162.31206594598763 39.169349999999994 5.72311E-12 213.06523674049876 125.04883301991349 183.45620265105612 657.9073000084877 304.173 5.72313E-12 759.9399775455402 592.8527098474576 763.462203142945 737.351;86.3883;5.72311E-12;21.9973;628.678;94.1074;2.71598E-7;882.629;955.628;529.244;292.216;126.653;728.316;21.9311;197.273;17.3097;39.6865;14.7631;109.609;131.7;240.861;42.4612;104.19;12.8863;212.603;56.6562;14.384;986.476;415.991;191.145;22.9134;760.927 446.625;26.6888;5.72311E-12;5.02186;389.239;37.7692;2.71598E-7;625.677;735.228;356.883;147.515;85.587;443.137;6.82654;116.413;3.12114;15.7729;9.42992;29.3336;39.9158;78.9726;20.6424;38.4229;9.13136;119.81;22.3266;4.89199;552.974;288.048;113.564;11.4115;413.607 2108.09;262.273;5.72313E-12;80.1461;1509.86;148.485;2.71599E-7;1106.02;1288.97;1021.06;658.494;240.486;2039.06;76.1794;496.915;90.6321;157.407;25.7196;346.073;397.209;847.87;98.0534;163.044;19.3234;1510.69;150.565;58.2504;2230.86;720.942;510.267;50.1592;2639.93 4 28 4 362282;24426;24296;29397 PCK1_9439;GSTP1_8762;CYP1A1_8415;CCL11_33230 385.84235 272.00355 468.3733694917656 232.10457000000002 183.15645999999998 269.46112881831175 824.2407499999999 523.3897999999999 1049.2606125218956 529.244;14.7631;12.8863;986.476 356.883;9.42992;9.13136;552.974 1021.06;25.7196;19.3234;2230.86 28 315852;360243;24832;25671;291463;25682;299112;288583;363131;300795;313108;81687;291234;316273;293502;362376;156275;25283;81919;24367;29243;84032;297594;114494;116599;25612;29657;29221 TTK_32727;TOP2A_10059;THY1_33010;SMAD1_32578;PPIC_9541;PPARD_9536;POLE2_9520;PLOD3_9507;PIK3R4_9484;NS5ATP9_9367;MMS22L_33129;MMP9_32531;MKI67_9232;MCM3_9207;KIF22_8963;HERC6_8794;GGT7_33026;GCLC_8699;FUT1_8668;FGG_8639;F10_8585;COL3A1_8354;CDCA3_8260;CCNA2_8221;BLVRA_8151;ASNS_8091;ARNTL_8086;ARG1_33267 254.7716107239858 118.131 300.7065872957727 152.34170822398588 39.169349999999994 207.9178389259551 634.1453785811287 304.173 732.1569220293393 737.351;86.3883;5.72311E-12;21.9973;628.678;94.1074;2.71598E-7;882.629;955.628;292.216;126.653;728.316;21.9311;197.273;17.3097;39.6865;109.609;131.7;240.861;42.4612;104.19;212.603;56.6562;14.384;415.991;191.145;22.9134;760.927 446.625;26.6888;5.72311E-12;5.02186;389.239;37.7692;2.71598E-7;625.677;735.228;147.515;85.587;443.137;6.82654;116.413;3.12114;15.7729;29.3336;39.9158;78.9726;20.6424;38.4229;119.81;22.3266;4.89199;288.048;113.564;11.4115;413.607 2108.09;262.273;5.72313E-12;80.1461;1509.86;148.485;2.71599E-7;1106.02;1288.97;658.494;240.486;2039.06;76.1794;496.915;90.6321;157.407;346.073;397.209;847.87;98.0534;163.044;1510.69;150.565;58.2504;720.942;510.267;50.1592;2639.93 0 Exp 2,5(0.16);Exp 4,11(0.35);Exp 5,2(0.07);Hill,4(0.13);Linear,3(0.1);Poly 2,6(0.19);Power,1(0.04) 2.0109630026140684 75.47503972053528 1.5018656253814697 15.48720932006836 2.449260636724005 1.8326352834701538 160.53796110602468 381.7729451609506 88.48872781616895 236.13540407580626 394.6015314140576 921.2130686029176 DOWN 0.125 0.875 0.0 GO:0044706 3 multi-multicellular organism process 43 45 3 3 2 3 2 2 66 43 2436 0.88316 0.33942 0.33942 4.44 81687;29221 mmp9;arg1 MMP9_32531;ARG1_33267 744.6215 744.6215 728.316 23.059459241277796 742.6807888214256 22.89554412418996 428.372 428.372 413.607 20.880863248437393 430.12935798053735 20.732434392912158 2339.495 2339.495 2039.06 424.87925161155937 2303.736663062464 421.85905362919976 728.316;760.927 443.137;413.607 2039.06;2639.93 0 2 0 2 81687;29221 MMP9_32531;ARG1_33267 744.6215 744.6215 23.059459241277796 428.372 428.372 20.880863248437393 2339.495 2339.495 424.87925161155937 728.316;760.927 443.137;413.607 2039.06;2639.93 0 Exp 2,1(0.5);Linear,1(0.5) 1.762092283500272 3.564971446990967 1.513624906539917 2.05134654045105 0.3802266137292722 1.7824857234954834 712.66272 776.5802799999999 399.43260000000004 457.3114 1750.6424000000002 2928.3475999999996 DOWN 0.0 1.0 0.0 GO:0031325 6 positive regulation of cellular metabolic process 693 746 45 44 31 28 22 22 46 724 1755 0.76007 0.32935 0.58978 2.95 688621;360243;24832;25671;25682;363131;25154;362282;259241;316351;81687;24426;25283;24367;361921;24854;306575;114494;29397;24232;29657;81639 tslp;top2a;thy1;smad1;ppard;pik3r4;pgr;pck1;nr1d2;npas2;mmp9;gstp1;gclc;fgg;ect2;clu;ckap2;ccna2;ccl11;c3;arntl;alox15 TSLP_32811;TOP2A_10059;THY1_33010;SMAD1_32578;PPARD_9536;PIK3R4_9484;PGR_32824;PCK1_9439;NR1D2_9358;NPAS2_9350;MMP9_32531;GSTP1_8762;GCLC_8699;FGG_8639;ECT2_8523;CLU_32773;CKAP2_8324;CCNA2_8221;CCL11_33230;C3_8175;ARNTL_8086;ALOX15_8036 285.74609545454564 90.24785 5.72311E-12 355.75026539636235 260.88917984039114 341.57542354456837 182.67417681818208 32.229 5.72311E-12 255.1592402511078 159.64513138041812 235.70888035218823 659.7392181818185 205.37900000000002 5.72313E-12 816.5451472573282 631.8726085141404 839.3035787910865 344.675;86.3883;5.72311E-12;21.9973;94.1074;955.628;283.618;529.244;29.1728;21.0878;728.316;14.7631;131.7;42.4612;10.0162;935.649;32.2386;14.384;986.476;234.759;22.9134;766.819 244.2;26.6888;5.72311E-12;5.02186;37.7692;735.228;138.711;356.883;3.35457;11.3305;443.137;9.42992;39.9158;20.6424;3.29405;808.484;15.2683;4.89199;552.974;129.148;11.4115;421.048 560.435;262.273;5.72313E-12;80.1461;148.485;1288.97;1554.21;1021.06;114.038;43.5624;2039.06;25.7196;397.209;98.0534;37.7305;1071.05;76.7052;58.2504;2230.86;694.216;50.1592;2662.07 4 18 4 362282;259241;24426;29397 PCK1_9439;NR1D2_9358;GSTP1_8762;CCL11_33230 389.913975 279.20840000000004 464.1018135036922 230.6603725 183.15645999999998 271.06522408744866 847.9194 567.549 1025.8487203096306 529.244;29.1728;14.7631;986.476 356.883;3.35457;9.42992;552.974 1021.06;114.038;25.7196;2230.86 18 688621;360243;24832;25671;25682;363131;25154;316351;81687;25283;24367;361921;24854;306575;114494;24232;29657;81639 TSLP_32811;TOP2A_10059;THY1_33010;SMAD1_32578;PPARD_9536;PIK3R4_9484;PGR_32824;NPAS2_9350;MMP9_32531;GCLC_8699;FGG_8639;ECT2_8523;CLU_32773;CKAP2_8324;CCNA2_8221;C3_8175;ARNTL_8086;ALOX15_8036 262.5976777777781 90.24785 339.4201563545852 172.01057777777808 32.229 258.45063317008254 617.9214000000003 205.37900000000002 792.2954170890513 344.675;86.3883;5.72311E-12;21.9973;94.1074;955.628;283.618;21.0878;728.316;131.7;42.4612;10.0162;935.649;32.2386;14.384;234.759;22.9134;766.819 244.2;26.6888;5.72311E-12;5.02186;37.7692;735.228;138.711;11.3305;443.137;39.9158;20.6424;3.29405;808.484;15.2683;4.89199;129.148;11.4115;421.048 560.435;262.273;5.72313E-12;80.1461;148.485;1288.97;1554.21;43.5624;2039.06;397.209;98.0534;37.7305;1071.05;76.7052;58.2504;694.216;50.1592;2662.07 0 Exp 2,2(0.1);Exp 4,10(0.46);Exp 5,1(0.05);Hill,2(0.1);Linear,2(0.1);Poly 2,4(0.19);Power,1(0.05) 1.9622514483133802 44.78315877914429 1.5018656253814697 3.5281898975372314 0.6181731297132372 1.9010515809059143 137.08752105918796 434.40466984990354 76.0499165178547 289.2984371185095 318.5267179311772 1000.9517184324595 DOWN 0.18181818181818182 0.8181818181818182 0.0 GO:0048678 5 response to axon injury 34 36 4 4 2 3 2 2 66 34 2445 0.93054 0.24955 0.24955 5.56 338475;29221 nrep;arg1 NREP_9364;ARG1_33267 411.235 411.235 61.543 494.53916905337235 443.8257602435752 492.386712271454 219.63945 219.63945 25.6719 274.3115398702815 237.71692937351636 273.11761273305893 1394.359 1394.359 148.788 1761.5034010986185 1510.4443145835482 1753.836546419899 0.5 411.235 61.543;760.927 25.6719;413.607 148.788;2639.93 0 2 0 2 338475;29221 NREP_9364;ARG1_33267 411.235 411.235 494.53916905337235 219.63945 219.63945 274.3115398702815 1394.359 1394.359 1761.5034010986185 61.543;760.927 25.6719;413.607 148.788;2639.93 0 Exp 2,1(0.5);Exp 4,1(0.5) 1.6443529759270972 3.2999966144561768 1.513624906539917 1.7863717079162598 0.19286111280015236 1.6499983072280884 -274.16131999999993 1096.63132 -160.536948 599.815848 -1046.9601599999996 3835.6781599999995 DOWN 0.0 1.0 0.0 GO:0051171 5 regulation of nitrogen compound metabolic process 917 985 55 52 33 31 23 23 45 962 1517 0.24162 0.8309 0.45025 2.34 688621;360243;24832;25671;295703;25682;25154;362282;304545;259241;316351;81687;24426;25283;24367;361921;24854;306575;114494;29397;24232;29657;81639 tslp;top2a;thy1;smad1;serping1;ppard;pgr;pck1;oasl;nr1d2;npas2;mmp9;gstp1;gclc;fgg;ect2;clu;ckap2;ccna2;ccl11;c3;arntl;alox15 TSLP_32811;TOP2A_10059;THY1_33010;SMAD1_32578;SERPING1_32597;PPARD_9536;PGR_32824;PCK1_9439;OASL_9389;NR1D2_9358;NPAS2_9350;MMP9_32531;GSTP1_8762;GCLC_8699;FGG_8639;ECT2_8523;CLU_32773;CKAP2_8324;CCNA2_8221;CCL11_33230;C3_8175;ARNTL_8086;ALOX15_8036 236.5129739130437 76.6126 5.72311E-12 320.5927054258651 238.46564707857576 325.2357645711478 144.59923434782633 26.6888 5.72311E-12 221.6569636941925 142.76627386713773 219.88806760089895 590.6595782608699 148.485 5.72313E-12 796.8500398418174 597.5982708970389 827.2088899474921 344.675;86.3883;5.72311E-12;21.9973;32.3997;94.1074;283.618;529.244;76.6126;29.1728;21.0878;728.316;14.7631;131.7;42.4612;10.0162;935.649;32.2386;14.384;986.476;234.759;22.9134;766.819 244.2;26.6888;5.72311E-12;5.02186;13.7308;37.7692;138.711;356.883;28.4477;3.35457;11.3305;443.137;9.42992;39.9158;20.6424;3.29405;808.484;15.2683;4.89199;552.974;129.148;11.4115;421.048 560.435;262.273;5.72313E-12;80.1461;99.4885;148.485;1554.21;1021.06;260.389;114.038;43.5624;2039.06;25.7196;397.209;98.0534;37.7305;1071.05;76.7052;58.2504;2230.86;694.216;50.1592;2662.07 4 19 4 362282;259241;24426;29397 PCK1_9439;NR1D2_9358;GSTP1_8762;CCL11_33230 389.913975 279.20840000000004 464.1018135036922 230.6603725 183.15645999999998 271.06522408744866 847.9194 567.549 1025.8487203096306 529.244;29.1728;14.7631;986.476 356.883;3.35457;9.42992;552.974 1021.06;114.038;25.7196;2230.86 19 688621;360243;24832;25671;295703;25682;25154;304545;316351;81687;25283;24367;361921;24854;306575;114494;24232;29657;81639 TSLP_32811;TOP2A_10059;THY1_33010;SMAD1_32578;SERPING1_32597;PPARD_9536;PGR_32824;OASL_9389;NPAS2_9350;MMP9_32531;GCLC_8699;FGG_8639;ECT2_8523;CLU_32773;CKAP2_8324;CCNA2_8221;C3_8175;ARNTL_8086;ALOX15_8036 204.21802631578976 76.6126 288.77497615829355 126.48110000000031 26.6888 214.0362892399883 536.4996157894739 148.485 763.4635881712246 344.675;86.3883;5.72311E-12;21.9973;32.3997;94.1074;283.618;76.6126;21.0878;728.316;131.7;42.4612;10.0162;935.649;32.2386;14.384;234.759;22.9134;766.819 244.2;26.6888;5.72311E-12;5.02186;13.7308;37.7692;138.711;28.4477;11.3305;443.137;39.9158;20.6424;3.29405;808.484;15.2683;4.89199;129.148;11.4115;421.048 560.435;262.273;5.72313E-12;80.1461;99.4885;148.485;1554.21;260.389;43.5624;2039.06;397.209;98.0534;37.7305;1071.05;76.7052;58.2504;694.216;50.1592;2662.07 0 Exp 2,2(0.09);Exp 4,12(0.53);Exp 5,1(0.05);Hill,2(0.09);Linear,2(0.09);Poly 2,3(0.14);Power,1(0.05) 1.9706792281466385 46.892354249954224 1.5021449327468872 3.5281898975372314 0.5977559183033302 1.8927439451217651 105.49050167226434 367.53544615382316 54.01063741135128 235.18783128430147 264.99632872888225 916.3228277928574 DOWN 0.17391304347826086 0.8260869565217391 0.0 GO:1902532 7 negative regulation of intracellular signal transduction 138 146 10 9 7 4 4 4 64 142 2337 0.64987 0.554 0.79496 2.74 81687;24426;24854;29657 mmp9;gstp1;clu;arntl MMP9_32531;GSTP1_8762;CLU_32773;ARNTL_8086 425.41037500000004 375.6147 14.7631 477.0500572782719 575.0442438071101 424.3765475933238 318.115605 227.27425 9.42992 385.33352314170315 411.9788083945842 343.30383134650583 796.4972 560.6046 25.7196 960.9821487827683 1202.8384411125194 977.977878827437 728.316;14.7631;935.649;22.9134 443.137;9.42992;808.484;11.4115 2039.06;25.7196;1071.05;50.1592 1 3 1 24426 GSTP1_8762 14.7631 14.7631 9.42992 9.42992 25.7196 25.7196 14.7631 9.42992 25.7196 3 81687;24854;29657 MMP9_32531;CLU_32773;ARNTL_8086 562.2928 728.316 478.4812912544439 421.0108333333333 443.137 398.99663908682663 1053.4230666666665 1071.05 994.5675591151227 728.316;935.649;22.9134 443.137;808.484;11.4115 2039.06;1071.05;50.1592 0 Exp 4,2(0.5);Linear,1(0.25);Poly 2,1(0.25) 2.4949055337072576 10.577374815940857 1.5548590421676636 3.5281898975372314 0.9929124551090024 2.747162938117981 -42.098681132706474 892.9194311327063 -59.51124767886898 695.742457678869 -145.265305807113 1738.2597058071128 DOWN 0.25 0.75 0.0 GO:0051130 6 positive regulation of cellular component organization 262 280 15 14 9 11 9 9 59 271 2208 0.7923 0.32894 0.5536 3.21 684352;24832;25671;81687;24854;29397;24232;246142;81639 twf2;thy1;smad1;mmp9;clu;ccl11;c3;bmf;alox15 TWF2_10109;THY1_33010;SMAD1_32578;MMP9_32531;CLU_32773;CCL11_33230;C3_8175;BMF_8152;ALOX15_8036 436.8684777777784 234.759 5.72311E-12 409.01550609381394 504.31364945470966 398.204375277989 281.3753066666673 129.148 5.72311E-12 285.51779587414956 320.60332430568104 271.1356441720209 1032.961344444445 694.216 5.72313E-12 1024.1753338053823 1226.2967215231092 1050.0877841749348 138.399;5.72311E-12;21.9973;728.316;935.649;986.476;234.759;119.401;766.819 90.7363;5.72311E-12;5.02186;443.137;808.484;552.974;129.148;81.8286;421.048 299.165;5.72313E-12;80.1461;2039.06;1071.05;2230.86;694.216;220.085;2662.07 1 8 1 29397 CCL11_33230 986.476 986.476 552.974 552.974 2230.86 2230.86 986.476 552.974 2230.86 8 684352;24832;25671;81687;24854;24232;246142;81639 TWF2_10109;THY1_33010;SMAD1_32578;MMP9_32531;CLU_32773;C3_8175;BMF_8152;ALOX15_8036 368.1675375000007 186.579 377.6851469823914 247.4254700000007 109.94215 285.15076528259317 883.2240125000008 496.69050000000004 983.9533654308158 138.399;5.72311E-12;21.9973;728.316;935.649;234.759;119.401;766.819 90.7363;5.72311E-12;5.02186;443.137;808.484;129.148;81.8286;421.048 299.165;5.72313E-12;80.1461;2039.06;1071.05;694.216;220.085;2662.07 0 Exp 2,1(0.12);Exp 4,1(0.12);Hill,1(0.12);Linear,1(0.12);Poly 2,4(0.45);Power,1(0.12) 1.7222418091822098 15.591054558753967 1.5021449327468872 2.05134654045105 0.20060313947023897 1.6932154893875122 169.64501379648652 704.0919417590702 94.83701336222293 467.9135999711116 363.8334596915954 1702.0892291972948 DOWN 0.1111111111111111 0.8888888888888888 0.0 GO:0042325 8 regulation of phosphorylation 405 429 31 29 17 15 12 12 56 417 2062 0.6457 0.48006 0.8694 2.8 688621;24832;363131;81687;24426;24367;361921;24854;114494;29397;24232;81639 tslp;thy1;pik3r4;mmp9;gstp1;fgg;ect2;clu;ccna2;ccl11;c3;alox15 TSLP_32811;THY1_33010;PIK3R4_9484;MMP9_32531;GSTP1_8762;FGG_8639;ECT2_8523;CLU_32773;CCNA2_8221;CCL11_33230;C3_8175;ALOX15_8036 419.4955416666671 289.717 5.72311E-12 420.4734404206508 391.27313167350445 405.9102735136174 281.03978000000046 186.67399999999998 5.72311E-12 301.9182639216577 253.3819020213259 278.2091198125917 897.2012416666671 627.3254999999999 5.72313E-12 962.0614970708671 900.3134248090257 1006.0469740540061 344.675;5.72311E-12;955.628;728.316;14.7631;42.4612;10.0162;935.649;14.384;986.476;234.759;766.819 244.2;5.72311E-12;735.228;443.137;9.42992;20.6424;3.29405;808.484;4.89199;552.974;129.148;421.048 560.435;5.72313E-12;1288.97;2039.06;25.7196;98.0534;37.7305;1071.05;58.2504;2230.86;694.216;2662.07 2 10 2 24426;29397 GSTP1_8762;CCL11_33230 500.61955 500.61955 687.1047809564456 281.20196000000004 281.20196000000004 384.3437048418033 1128.2898 1128.2898 1559.2697303084162 14.7631;986.476 9.42992;552.974 25.7196;2230.86 10 688621;24832;363131;81687;24367;361921;24854;114494;24232;81639 TSLP_32811;THY1_33010;PIK3R4_9484;MMP9_32531;FGG_8639;ECT2_8523;CLU_32773;CCNA2_8221;C3_8175;ALOX15_8036 403.27074000000056 289.717 402.33615350163205 281.00734400000056 186.67399999999998 308.21725245658496 850.9835300000007 627.3254999999999 920.2474825013318 344.675;5.72311E-12;955.628;728.316;42.4612;10.0162;935.649;14.384;234.759;766.819 244.2;5.72311E-12;735.228;443.137;20.6424;3.29405;808.484;4.89199;129.148;421.048 560.435;5.72313E-12;1288.97;2039.06;98.0534;37.7305;1071.05;58.2504;694.216;2662.07 0 Exp 2,2(0.17);Exp 4,4(0.34);Hill,1(0.09);Linear,1(0.09);Poly 2,3(0.25);Power,1(0.09) 1.8703511870267657 23.295981407165527 1.5018656253814697 3.5281898975372314 0.6219060895708245 1.6608489751815796 181.59029673299534 657.400786600339 110.21344087053552 451.8661191294653 352.86370664204446 1441.5387766912897 DOWN 0.16666666666666666 0.8333333333333334 0.0 GO:0007271 8 synaptic transmission, cholinergic 4 4 1 1 1 1 1 1 67 3 2476 0.99593 0.10265 0.10265 25.0 170945 chrna2 CHRNA2_32401 163.479 163.479 163.479 163.47899999999998 101.968 101.968 101.968 101.968 414.362 414.362 414.362 414.362 0.0 163.479 0.0 163.479 163.479 101.968 414.362 0 1 0 1 170945 CHRNA2_32401 163.479 163.479 101.968 101.968 414.362 414.362 163.479 101.968 414.362 0 Poly 2,1(1) 1.7986326217651367 1.7986326217651367 1.7986326217651367 1.7986326217651367 0.0 1.7986326217651367 163.479 163.479 101.968 101.968 414.362 414.362 DOWN 0.0 1.0 0.0 GO:1901652 5 response to peptide 225 236 15 15 9 13 8 8 60 228 2251 0.82706 0.29162 0.52132 3.39 25154;362282;81687;24426;25283;114494;29221;170913 pgr;pck1;mmp9;gstp1;gclc;ccna2;arg1;abcb1a PGR_32824;PCK1_9439;MMP9_32531;GSTP1_8762;GCLC_8699;CCNA2_8221;ARG1_33267;ABCB1A_7938 333.7417625 245.3 14.384 302.2617718973688 324.54096628538247 314.3467557418022 190.57508875 128.368 4.89199 184.82906368682683 179.3147811506704 190.5637766192497 1158.373625 1276.3049999999998 25.7196 953.0378267519226 1171.4622731055726 992.1990352310204 283.618;529.244;728.316;14.7631;131.7;14.384;760.927;206.982 138.711;356.883;443.137;9.42992;39.9158;4.89199;413.607;118.025 1554.21;1021.06;2039.06;25.7196;397.209;58.2504;2639.93;1531.55 2 6 2 362282;24426 PCK1_9439;GSTP1_8762 272.00355 272.00355 363.7929331809581 183.15645999999998 183.15645999999998 245.686429012152 523.3897999999999 523.3897999999999 703.8119464289307 529.244;14.7631 356.883;9.42992 1021.06;25.7196 6 25154;81687;25283;114494;29221;170913 PGR_32824;MMP9_32531;GCLC_8699;CCNA2_8221;ARG1_33267;ABCB1A_7938 354.32116666666667 245.3 315.28579669906895 193.047965 128.368 189.00999723610005 1370.0348999999999 1542.88 978.5095350146672 283.618;728.316;131.7;14.384;760.927;206.982 138.711;443.137;39.9158;4.89199;413.607;118.025 1554.21;2039.06;397.209;58.2504;2639.93;1531.55 0 Exp 2,1(0.13);Exp 4,2(0.25);Hill,1(0.13);Linear,2(0.25);Poly 2,2(0.25) 1.8930055591647463 15.734120726585388 1.513624906539917 3.5281898975372314 0.6633648496822057 1.757135808467865 124.2850408699509 543.198484130049 62.495082142550814 318.65509535744917 497.9521051768969 1818.7951448231029 DOWN 0.25 0.75 0.0 GO:1901698 4 response to nitrogen compound 416 438 28 27 15 21 13 13 55 425 2054 0.72913 0.38444 0.62722 2.97 25671;25154;362282;24314;81687;24426;25283;84032;113902;114494;25612;29221;170913 smad1;pgr;pck1;nqo1;mmp9;gstp1;gclc;col3a1;ces1d;ccna2;asns;arg1;abcb1a SMAD1_32578;PGR_32824;PCK1_9439;NQO1_33055;MMP9_32531;GSTP1_8762;GCLC_8699;COL3A1_8354;CES1D_32914;CCNA2_8221;ASNS_8091;ARG1_33267;ABCB1A_7938 240.9560846153846 191.145 11.0684 267.523874131646 252.92843526050757 277.4262051798539 136.5322646153846 113.564 4.18343 161.94223809198 139.77438374781704 166.19771545418604 882.4053538461538 510.267 17.0564 891.0191484209282 923.225276890863 917.7357908994221 21.9973;283.618;529.244;25.6813;728.316;14.7631;131.7;212.603;11.0684;14.384;191.145;760.927;206.982 5.02186;138.711;356.883;7.73944;443.137;9.42992;39.9158;119.81;4.18343;4.89199;113.564;413.607;118.025 80.1461;1554.21;1021.06;86.1211;2039.06;25.7196;397.209;1510.69;17.0564;58.2504;510.267;2639.93;1531.55 3 10 3 362282;24314;24426 PCK1_9439;NQO1_33055;GSTP1_8762 189.89613333333332 25.6813 293.9345721946014 124.68412 9.42992 201.0919051966001 377.63356666666664 86.1211 558.0414560179228 529.244;25.6813;14.7631 356.883;7.73944;9.42992 1021.06;86.1211;25.7196 10 25671;25154;81687;25283;84032;113902;114494;25612;29221;170913 SMAD1_32578;PGR_32824;MMP9_32531;GCLC_8699;COL3A1_8354;CES1D_32914;CCNA2_8221;ASNS_8091;ARG1_33267;ABCB1A_7938 256.27407 199.0635 274.0367880139861 140.086708 115.7945 160.9969208806498 1033.83689 1010.4785 937.518128307549 21.9973;283.618;728.316;131.7;212.603;11.0684;14.384;191.145;760.927;206.982 5.02186;138.711;443.137;39.9158;119.81;4.18343;4.89199;113.564;413.607;118.025 80.1461;1554.21;2039.06;397.209;1510.69;17.0564;58.2504;510.267;2639.93;1531.55 0 Exp 2,1(0.08);Exp 4,3(0.24);Exp 5,1(0.08);Hill,2(0.16);Linear,2(0.16);Poly 2,4(0.31) 1.845185724849749 24.645448803901672 1.513624906539917 3.5281898975372314 0.532200268859815 1.6932154893875122 95.52845004914224 386.383719181627 48.49946119354601 224.5650680372232 398.04182730601906 1366.7688803862886 DOWN 0.23076923076923078 0.7692307692307693 0.0 GO:0050673 4 epithelial cell proliferation 37 39 4 4 3 2 2 2 66 37 2442 0.91592 0.27962 0.27962 5.13 25682;291234 ppard;mki67 PPARD_9536;MKI67_9232 58.01925 58.01925 21.9311 51.036351170954596 54.31201277272727 50.766346383469894 22.29787 22.29787 6.82654 21.879764713949736 20.708542463636363 21.76401111702786 112.3322 112.3322 76.1794 51.127780077762104 108.61832145454545 50.85729159107111 0.5 58.01925 94.1074;21.9311 37.7692;6.82654 148.485;76.1794 0 2 0 2 25682;291234 PPARD_9536;MKI67_9232 58.01925 58.01925 51.036351170954596 22.29787 22.29787 21.879764713949736 112.3322 112.3322 51.127780077762104 94.1074;21.9311 37.7692;6.82654 148.485;76.1794 0 Exp 4,1(0.5);Exp 5,1(0.5) 1.9304520062593058 3.8609408140182495 1.922041654586792 1.9388991594314575 0.011920055989548073 1.9304704070091248 -12.713523999999992 128.752024 -8.025936799999993 52.62167679999999 41.47271199999999 183.191688 DOWN 0.0 1.0 0.0 GO:0007015 6 actin filament organization 44 45 2 2 2 2 2 2 66 43 2436 0.88316 0.33942 0.33942 4.44 684352;29397 twf2;ccl11 TWF2_10109;CCL11_33230 562.4375 562.4375 138.399 599.6809976683436 653.8090325417766 585.5935322785201 321.85515000000004 321.85515000000004 90.7363 326.85141219007295 371.6564853122252 319.17314995607586 1265.0125 1265.0125 299.165 1365.914633684148 1473.1326737027266 1333.827115149634 138.399;986.476 90.7363;552.974 299.165;2230.86 1 1 1 29397 CCL11_33230 986.476 986.476 552.974 552.974 2230.86 2230.86 986.476 552.974 2230.86 1 684352 TWF2_10109 138.399 138.399 90.7363 90.7363 299.165 299.165 138.399 90.7363 299.165 0 Poly 2,1(0.5);Power,1(0.5) 1.8857566407919333 3.7761374711990356 1.7946586608886719 1.9814788103103638 0.1321017945183624 1.8880687355995178 -268.67796 1393.55296 -131.13779600000004 774.8480959999999 -628.0486000000003 3158.0736000000006 CONFLICT 0.5 0.5 0.0 GO:0044849 4 estrous cycle 13 15 2 2 2 2 2 2 66 13 2466 0.99342 0.058963 0.058963 13.33 25154;24854 pgr;clu PGR_32824;CLU_32773 609.6335 609.6335 283.618 461.05554164384574 687.9871536503897 447.54175492323554 473.5975 473.5975 138.711 473.6010301556576 554.0831849848895 459.7195283969633 1312.63 1312.63 1071.05 341.6457123980915 1254.5693383171624 331.6318922086687 0.0 283.618 0.5 609.6335 283.618;935.649 138.711;808.484 1554.21;1071.05 0 2 0 2 25154;24854 PGR_32824;CLU_32773 609.6335 609.6335 461.05554164384574 473.5975 473.5975 473.6010301556576 1312.63 1312.63 341.6457123980915 283.618;935.649 138.711;808.484 1554.21;1071.05 0 Poly 2,2(1) 1.547706125038475 3.095445156097412 1.5405861139297485 1.5548590421676636 0.010092484344418685 1.547722578048706 -29.356879999999933 1248.6238799999996 -182.78003999999993 1129.97504 839.1332 1786.1268000000002 DOWN 0.0 1.0 0.0 GO:0090277 7 positive regulation of peptide hormone secretion 36 38 3 3 2 2 2 2 66 36 2443 0.92093 0.26959 0.26959 5.26 25682;24367 ppard;fgg PPARD_9536;FGG_8639 68.2843 68.2843 42.4612 36.519378242516666 61.33551246875868 35.17234269865073 29.205799999999996 29.205799999999996 20.6424 12.11047642002577 26.901458261594 11.663775436164732 123.26920000000001 123.26920000000001 98.0534 35.66052634608748 116.48383199111358 34.345169984263634 0.5 68.2843 94.1074;42.4612 37.7692;20.6424 148.485;98.0534 0 2 0 2 25682;24367 PPARD_9536;FGG_8639 68.2843 68.2843 36.519378242516666 29.205799999999996 29.205799999999996 12.11047642002577 123.26920000000001 123.26920000000001 35.66052634608748 94.1074;42.4612 37.7692;20.6424 148.485;98.0534 0 Exp 4,1(0.5);Exp 5,1(0.5) 2.3373310115762087 4.756537318229675 1.9388991594314575 2.8176381587982178 0.6213623053453174 2.3782686591148376 17.671024000000003 118.897576 12.421535999999996 45.990064 73.846232 172.69216800000004 DOWN 0.0 1.0 0.0 GO:0010817 4 regulation of hormone levels 159 176 15 14 8 11 8 8 60 168 2311 0.9583 0.093417 0.13788 4.55 286989;25682;24367;64191;312495;24296;29657;170913 ugt2b7;ppard;fgg;dhcr7;cyp26b1;cyp1a1;arntl;abcb1a UGT2B7_33032;PPARD_9536;FGG_8639;DHCR7_8466;CYP26B1_8418;CYP1A1_8415;ARNTL_8086;ABCB1A_7938 74.2440125 38.5869 12.8863 73.46298747498514 89.38913826791905 77.44925253323115 34.084832500000005 17.70765 9.13136 37.05633935844013 39.55038619663321 38.62915727493955 308.8548875 101.5387 19.3234 515.65545190938 381.36390726408376 542.3871990442319 34.7126;94.1074;42.4612;161.702;18.1872;12.8863;22.9134;206.982 14.7729;37.7692;20.6424;50.9087;10.0176;9.13136;11.4115;118.025 105.024;148.485;98.0534;481.517;36.7271;19.3234;50.1592;1531.55 3 5 3 286989;312495;24296 UGT2B7_33032;CYP26B1_8418;CYP1A1_8415 21.928700000000003 18.1872 11.384022119180901 11.307286666666668 10.0176 3.0338444532528897 53.6915 36.7271 45.29891125192746 34.7126;18.1872;12.8863 14.7729;10.0176;9.13136 105.024;36.7271;19.3234 5 25682;24367;64191;29657;170913 PPARD_9536;FGG_8639;DHCR7_8466;ARNTL_8086;ABCB1A_7938 105.63319999999999 94.1074 78.07272340030161 47.75136 37.7692 42.14106646162388 461.95292 148.485 621.4257260782595 94.1074;42.4612;161.702;22.9134;206.982 37.7692;20.6424;50.9087;11.4115;118.025 148.485;98.0534;481.517;50.1592;1531.55 0 Exp 4,6(0.75);Exp 5,1(0.13);Poly 2,1(0.13) 3.2425476209164517 35.38814735412598 1.7927976846694946 15.48720932006836 4.6780151223339566 2.4539865255355835 23.336759422411305 125.15126557758869 8.406099430623094 59.763565569376915 -48.4761099649175 666.1858849649175 DOWN 0.375 0.625 0.0 GO:0060137 4 maternal process involved in parturition 6 6 3 3 2 3 2 2 66 4 2475 0.99966 0.0098306 0.0098306 33.33 24296;29657 cyp1a1;arntl CYP1A1_8415;ARNTL_8086 17.89985 17.89985 12.8863 7.090230405635626 15.503692294182216 6.22801924392501 10.27143 10.27143 9.13136 1.6123024560546968 9.726549124039517 1.4162375760532147 34.741299999999995 34.741299999999995 19.3234 21.80420328331215 27.372525400658617 19.152691785443697 0.0 12.8863 0.0 12.8863 12.8863;22.9134 9.13136;11.4115 19.3234;50.1592 1 1 1 24296 CYP1A1_8415 12.8863 12.8863 9.13136 9.13136 19.3234 19.3234 12.8863 9.13136 19.3234 1 29657 ARNTL_8086 22.9134 22.9134 11.4115 11.4115 50.1592 50.1592 22.9134 11.4115 50.1592 0 Exp 4,2(1) 7.302201151568674 18.93018865585327 3.442979335784912 15.48720932006836 8.51655669605717 9.465094327926636 8.073292000000002 27.726408 8.0368928 12.5059672 4.522216 64.96038399999999 CONFLICT 0.5 0.5 0.0 GO:0071495 4 cellular response to endogenous stimulus 313 332 25 24 14 18 12 12 56 320 2159 0.90373 0.16657 0.27081 3.61 25671;288583;25154;362282;24426;25283;25315;84032;114494;25612;29221;170913 smad1;plod3;pgr;pck1;gstp1;gclc;ephx1;col3a1;ccna2;asns;arg1;abcb1a SMAD1_32578;PLOD3_9507;PGR_32824;PCK1_9439;GSTP1_8762;GCLC_8699;EPHX1_8567;COL3A1_8354;CCNA2_8221;ASNS_8091;ARG1_33267;ABCB1A_7938 274.1025416666667 199.0635 14.384 295.6298415689626 234.1136535744033 260.625164607097 163.70793916666665 115.7945 4.89199 197.9019729988451 129.52117450543423 162.87488358208358 876.3957166666668 765.6635 25.7196 825.5542969121698 860.5669269070592 865.7661043961527 21.9973;882.629;283.618;529.244;14.7631;131.7;39.2381;212.603;14.384;191.145;760.927;206.982 5.02186;625.677;138.711;356.883;9.42992;39.9158;18.9587;119.81;4.89199;113.564;413.607;118.025 80.1461;1106.02;1554.21;1021.06;25.7196;397.209;81.6965;1510.69;58.2504;510.267;2639.93;1531.55 3 9 3 362282;24426;25315 PCK1_9439;GSTP1_8762;EPHX1_8567 194.4150666666667 39.2381 290.22847440267356 128.42387333333332 18.9587 197.9087639040882 376.15869999999995 81.6965 559.2017689436166 529.244;14.7631;39.2381 356.883;9.42992;18.9587 1021.06;25.7196;81.6965 9 25671;288583;25154;25283;84032;114494;25612;29221;170913 SMAD1_32578;PLOD3_9507;PGR_32824;GCLC_8699;COL3A1_8354;CCNA2_8221;ASNS_8091;ARG1_33267;ABCB1A_7938 300.6650333333333 206.982 309.7381002741026 175.46929444444444 118.025 208.41709419400428 1043.1413888888887 1106.02 856.6342087275357 21.9973;882.629;283.618;131.7;212.603;14.384;191.145;760.927;206.982 5.02186;625.677;138.711;39.9158;119.81;4.89199;113.564;413.607;118.025 80.1461;1106.02;1554.21;397.209;1510.69;58.2504;510.267;2639.93;1531.55 0 Exp 2,1(0.09);Exp 4,4(0.34);Hill,1(0.09);Linear,1(0.09);Poly 2,5(0.42) 1.8281156409886523 22.558857321739197 1.513624906539917 3.5281898975372314 0.5459130909731531 1.7046421766281128 106.83421242854624 441.3708709047871 51.73435693030616 275.6815214030271 409.29440102483125 1343.4970323085026 DOWN 0.25 0.75 0.0 GO:0044255 4 cellular lipid metabolic process 218 243 16 16 13 13 11 11 57 232 2247 0.97531 0.054042 0.088952 4.53 25682;25154;362282;24426;25315;312495;24296;113902;24232;81639;252898 ppard;pgr;pck1;gstp1;ephx1;cyp26b1;cyp1a1;ces1d;c3;alox15;acox2 PPARD_9536;PGR_32824;PCK1_9439;GSTP1_8762;EPHX1_8567;CYP26B1_8418;CYP1A1_8415;CES1D_32914;C3_8175;ALOX15_8036;ACOX2_32902 249.8221363636364 94.1074 11.0684 296.8073876639301 237.6651943974774 311.89401546826707 142.52883727272726 37.7692 4.18343 175.0062961972625 132.042948482888 178.29051659277442 777.1230909090908 148.485 17.0564 982.2902521299523 767.6833349580015 1066.2115335827884 94.1074;283.618;529.244;14.7631;39.2381;18.1872;12.8863;11.0684;234.759;766.819;743.353 37.7692;138.711;356.883;9.42992;18.9587;10.0176;9.13136;4.18343;129.148;421.048;432.537 148.485;1554.21;1021.06;25.7196;81.6965;36.7271;19.3234;17.0564;694.216;2662.07;2287.79 5 6 5 362282;24426;25315;312495;24296 PCK1_9439;GSTP1_8762;EPHX1_8567;CYP26B1_8418;CYP1A1_8415 122.86374 18.1872 227.41818698534868 80.88411599999999 10.0176 154.34244743880305 236.90532 36.7271 439.033301691588 529.244;14.7631;39.2381;18.1872;12.8863 356.883;9.42992;18.9587;10.0176;9.13136 1021.06;25.7196;81.6965;36.7271;19.3234 6 25682;25154;113902;24232;81639;252898 PPARD_9536;PGR_32824;CES1D_32914;C3_8175;ALOX15_8036;ACOX2_32902 355.6208 259.1885 324.44346540883816 193.89943833333334 133.92950000000002 187.69746004531444 1227.3045666666667 1124.213 1113.8028611560337 94.1074;283.618;11.0684;234.759;766.819;743.353 37.7692;138.711;4.18343;129.148;421.048;432.537 148.485;1554.21;17.0564;694.216;2662.07;2287.79 0 Exp 2,2(0.19);Exp 4,4(0.37);Exp 5,2(0.19);Linear,1(0.1);Poly 2,2(0.19) 2.2220881226951263 34.45290529727936 1.5021449327468872 15.48720932006836 4.139205956530949 1.6269687414169312 74.4201790747127 425.22409365256 39.10672526774577 245.95094927770873 196.62664772583958 1357.6195340923423 CONFLICT 0.45454545454545453 0.5454545454545454 0.0 GO:0071460 5 cellular response to cell-matrix adhesion 3 3 2 2 2 2 2 2 66 1 2478 0.99998 0.0020713 0.0020713 66.67 81687;24426 mmp9;gstp1 MMP9_32531;GSTP1_8762 371.53955 371.53955 14.7631 504.55809432532646 499.3739387985866 471.05796737788927 226.28346 226.28346 9.42992 306.67721731661646 303.98292627561835 286.315388168417 1032.3898 1032.3898 25.7196 1423.646649676836 1393.0836455123676 1329.1236521690073 0.0 14.7631 0.0 14.7631 728.316;14.7631 443.137;9.42992 2039.06;25.7196 1 1 1 24426 GSTP1_8762 14.7631 14.7631 9.42992 9.42992 25.7196 25.7196 14.7631 9.42992 25.7196 1 81687 MMP9_32531 728.316 728.316 443.137 443.137 2039.06 2039.06 728.316 443.137 2039.06 0 Exp 4,1(0.5);Linear,1(0.5) 2.6902676707657442 5.579536437988281 2.05134654045105 3.5281898975372314 1.044285952545945 2.7897682189941406 -327.74229199999996 1070.821392 -198.7494784 651.3163984 -940.6837919999998 3005.4633919999997 CONFLICT 0.5 0.5 0.0 GO:0051179 2 localization 693 737 38 37 28 26 19 19 49 718 1761 0.48818 0.61872 1.0 2.58 684352;315852;24832;313089;294881;170551;89776;25682;288583;363131;293502;24367;24854;170945;113902;29657;81639;24646;170913 twf2;ttk;thy1;slc7a13;slc7a12;slc5a6;slc22a7;ppard;plod3;pik3r4;kif22;fgg;clu;chrna2;ces1d;arntl;alox15;abcb1b;abcb1a TWF2_10109;TTK_32727;THY1_33010;SLC7A13_32952;SLC7A12_32838;SLC5A6_9881;SLC22A7_9847;PPARD_9536;PLOD3_9507;PIK3R4_9484;KIF22_8963;FGG_8639;CLU_32773;CHRNA2_32401;CES1D_32914;ARNTL_8086;ALOX15_8036;ABCB1B_7939;ABCB1A_7938 294.7719000000003 120.077 5.72311E-12 359.4639359747972 224.2888577985925 306.4394604156779 201.28942210526347 82.2177 5.72311E-12 270.0704685233806 146.6122179634003 225.86487344897097 638.1971894736845 221.286 5.72313E-12 782.2886506288856 572.791505775853 769.277622254827 138.399;737.351;5.72311E-12;397.931;37.9163;120.077;49.1516;94.1074;882.629;955.628;17.3097;42.4612;935.649;163.479;11.0684;22.9134;766.819;20.7941;206.982 90.7363;446.625;5.72311E-12;280.111;15.3983;82.2177;13.5995;37.7692;625.677;735.228;3.12114;20.6424;808.484;101.968;4.18343;11.4115;421.048;8.25355;118.025 299.165;2108.09;5.72313E-12;668.129;132.15;221.286;161.307;148.485;1106.02;1288.97;90.6321;98.0534;1071.05;414.362;17.0564;50.1592;2662.07;57.2115;1531.55 0 19 0 19 684352;315852;24832;313089;294881;170551;89776;25682;288583;363131;293502;24367;24854;170945;113902;29657;81639;24646;170913 TWF2_10109;TTK_32727;THY1_33010;SLC7A13_32952;SLC7A12_32838;SLC5A6_9881;SLC22A7_9847;PPARD_9536;PLOD3_9507;PIK3R4_9484;KIF22_8963;FGG_8639;CLU_32773;CHRNA2_32401;CES1D_32914;ARNTL_8086;ALOX15_8036;ABCB1B_7939;ABCB1A_7938 294.7719000000003 120.077 359.4639359747972 201.28942210526347 82.2177 270.0704685233806 638.1971894736845 221.286 782.2886506288856 138.399;737.351;5.72311E-12;397.931;37.9163;120.077;49.1516;94.1074;882.629;955.628;17.3097;42.4612;935.649;163.479;11.0684;22.9134;766.819;20.7941;206.982 90.7363;446.625;5.72311E-12;280.111;15.3983;82.2177;13.5995;37.7692;625.677;735.228;3.12114;20.6424;808.484;101.968;4.18343;11.4115;421.048;8.25355;118.025 299.165;2108.09;5.72313E-12;668.129;132.15;221.286;161.307;148.485;1106.02;1288.97;90.6321;98.0534;1071.05;414.362;17.0564;50.1592;2662.07;57.2115;1531.55 0 Exp 2,2(0.11);Exp 4,3(0.16);Exp 5,2(0.11);Hill,4(0.22);Linear,1(0.06);Poly 2,7(0.37) 1.9898471747640432 40.70998227596283 1.5018656253814697 6.191005229949951 1.095693329018358 1.8598893880844116 133.13720196354913 456.4065980364513 79.85092922847014 322.72791498205675 286.43731270371535 989.9570662436536 DOWN 0.0 1.0 0.0 GO:0006811 5 ion transport 243 256 14 14 10 11 8 8 60 248 2231 0.7608 0.37462 0.54508 3.12 313089;294881;170551;89776;25682;170945;24646;170913 slc7a13;slc7a12;slc5a6;slc22a7;ppard;chrna2;abcb1b;abcb1a SLC7A13_32952;SLC7A12_32838;SLC5A6_9881;SLC22A7_9847;PPARD_9536;CHRNA2_32401;ABCB1B_7939;ABCB1A_7938 136.3048 107.09219999999999 20.7941 123.5456152592463 119.94262405446293 107.93565279487727 82.16778125 59.993449999999996 8.25355 90.59614431900484 70.84989859127256 77.52898788697637 416.81006249999996 191.29649999999998 57.2115 491.595742756938 398.7646748924298 494.7383172442109 397.931;37.9163;120.077;49.1516;94.1074;163.479;20.7941;206.982 280.111;15.3983;82.2177;13.5995;37.7692;101.968;8.25355;118.025 668.129;132.15;221.286;161.307;148.485;414.362;57.2115;1531.55 0 8 0 8 313089;294881;170551;89776;25682;170945;24646;170913 SLC7A13_32952;SLC7A12_32838;SLC5A6_9881;SLC22A7_9847;PPARD_9536;CHRNA2_32401;ABCB1B_7939;ABCB1A_7938 136.3048 107.09219999999999 123.5456152592463 82.16778125 59.993449999999996 90.59614431900484 416.81006249999996 191.29649999999998 491.595742756938 397.931;37.9163;120.077;49.1516;94.1074;163.479;20.7941;206.982 280.111;15.3983;82.2177;13.5995;37.7692;101.968;8.25355;118.025 668.129;132.15;221.286;161.307;148.485;414.362;57.2115;1531.55 0 Exp 2,1(0.13);Exp 4,1(0.13);Exp 5,1(0.13);Hill,2(0.25);Poly 2,3(0.38) 2.1920281243874173 19.518550992012024 1.517665982246399 6.191005229949951 1.533654517679907 1.9053296446800232 50.692056511036284 221.9175434889637 19.387856212623042 144.94770628737697 76.15159286024897 757.468532139751 DOWN 0.0 1.0 0.0 GO:1902904 7 negative regulation of supramolecular fiber organization 31 35 4 4 3 4 3 3 65 32 2447 0.98695 0.064871 0.064871 8.57 684352;24854;306575 twf2;clu;ckap2 TWF2_10109;CLU_32773;CKAP2_8324 368.76219999999995 138.399 32.2386 493.79954500051946 288.4091609146504 471.55009661494154 304.82953333333336 90.7363 15.2683 437.80671660101723 236.50993189976074 415.87887952985716 482.30673333333334 299.165 76.7052 521.858281708754 380.5784963839405 511.14738834205684 0.5 85.3188 138.399;935.649;32.2386 90.7363;808.484;15.2683 299.165;1071.05;76.7052 0 3 0 3 684352;24854;306575 TWF2_10109;CLU_32773;CKAP2_8324 368.76219999999995 138.399 493.79954500051946 304.82953333333336 90.7363 437.80671660101723 482.30673333333334 299.165 521.858281708754 138.399;935.649;32.2386 90.7363;808.484;15.2683 299.165;1071.05;76.7052 0 Exp 4,1(0.34);Poly 2,2(0.67) 1.790831265172259 5.407734513282776 1.5548590421676636 2.0582168102264404 0.251772317079739 1.7946586608886719 -190.0245884542586 927.5489884542586 -190.59540500460866 800.2544716712753 -108.23150473650082 1072.8449714031676 DOWN 0.0 1.0 0.0 GO:0045595 5 regulation of cell differentiation 433 456 30 28 20 18 15 15 53 441 2038 0.85633 0.22356 0.33968 3.29 684352;24832;25671;25682;338475;259241;81687;361921;312495;245920;84032;24854;29397;29657;170913 twf2;thy1;smad1;ppard;nrep;nr1d2;mmp9;ect2;cyp26b1;cxcl10;col3a1;clu;ccl11;arntl;abcb1a TWF2_10109;THY1_33010;SMAD1_32578;PPARD_9536;NREP_9364;NR1D2_9358;MMP9_32531;ECT2_8523;CYP26B1_8418;CXCL10_8408;COL3A1_8354;CLU_32773;CCL11_33230;ARNTL_8086;ABCB1A_7938 275.792686666667 94.1074 5.72311E-12 359.54659152937273 291.55446735674894 370.046026584894 173.63393200000036 37.7692 5.72311E-12 251.12934874061355 183.57073325852411 255.54134433397473 750.2499266666671 148.788 5.72313E-12 863.8764564194855 804.4978799174557 888.5464189539636 138.399;5.72311E-12;21.9973;94.1074;61.543;29.1728;728.316;10.0162;18.1872;670.528;212.603;935.649;986.476;22.9134;206.982 90.7363;5.72311E-12;5.02186;37.7692;25.6719;3.35457;443.137;3.29405;10.0176;374.802;119.81;808.484;552.974;11.4115;118.025 299.165;5.72313E-12;80.1461;148.485;148.788;114.038;2039.06;37.7305;36.7271;1955.3;1510.69;1071.05;2230.86;50.1592;1531.55 3 12 3 259241;312495;29397 NR1D2_9358;CYP26B1_8418;CCL11_33230 344.612 29.1728 555.8976674927139 188.78205666666668 10.0176 315.4170694237673 793.8750333333334 114.038 1245.0656969149072 29.1728;18.1872;986.476 3.35457;10.0176;552.974 114.038;36.7271;2230.86 12 684352;24832;25671;25682;338475;81687;361921;245920;84032;24854;29657;170913 TWF2_10109;THY1_33010;SMAD1_32578;PPARD_9536;NREP_9364;MMP9_32531;ECT2_8523;CXCL10_8408;COL3A1_8354;CLU_32773;ARNTL_8086;ABCB1A_7938 258.5878583333338 116.25319999999999 326.69525975343475 169.84690083333382 64.25274999999999 249.19633470111881 739.3436500000006 223.97650000000002 816.8921958401643 138.399;5.72311E-12;21.9973;94.1074;61.543;728.316;10.0162;670.528;212.603;935.649;22.9134;206.982 90.7363;5.72311E-12;5.02186;37.7692;25.6719;443.137;3.29405;374.802;119.81;808.484;11.4115;118.025 299.165;5.72313E-12;80.1461;148.485;148.788;2039.06;37.7305;1955.3;1510.69;1071.05;50.1592;1531.55 0 Exp 2,1(0.07);Exp 4,6(0.4);Exp 5,1(0.07);Hill,1(0.07);Linear,1(0.07);Poly 2,4(0.27);Power,1(0.07) 1.9214973043643282 29.369826674461365 1.5548590421676636 3.442979335784912 0.4487333326022118 1.863204002380371 93.83700640595731 457.7483669273768 46.54494670560243 300.72291729439826 313.0681204912699 1187.431732842064 DOWN 0.2 0.8 0.0 GO:0019626 7 short-chain fatty acid catabolic process 3 3 2 2 2 2 2 2 66 1 2478 0.99998 0.0020713 0.0020713 66.67 362282;113902 pck1;ces1d PCK1_9439;CES1D_32914 270.1562 270.1562 11.0684 366.405480605408 228.88875263157897 361.7277592237969 180.53321499999998 180.53321499999998 4.18343 249.39625766857938 152.44426032548472 246.21233638808295 519.0581999999999 519.0581999999999 17.0564 709.937753895706 439.0994645429362 700.874322296583 0.0 11.0684 0.0 11.0684 529.244;11.0684 356.883;4.18343 1021.06;17.0564 1 1 1 362282 PCK1_9439 529.244 529.244 356.883 356.883 1021.06 1021.06 529.244 356.883 1021.06 1 113902 CES1D_32914 11.0684 11.0684 4.18343 4.18343 17.0564 17.0564 11.0684 4.18343 17.0564 0 Exp 5,1(0.5);Linear,1(0.5) 1.6191719513352205 3.238381266593933 1.611412525177002 1.6269687414169312 0.010999905992858234 1.6191906332969666 -237.655888 777.968288 -165.11236359999998 526.1787936 -464.86532799999986 1502.9817279999997 CONFLICT 0.5 0.5 0.0 GO:0006259 5 DNA metabolic process 110 119 9 9 8 7 7 7 61 112 2367 0.98741 0.037095 0.037095 5.88 360243;299112;300795;313108;291234;316273;293502 top2a;pole2;pclaf;mms22l;mki67;mcm3;kif22 TOP2A_10059;POLE2_9520;NS5ATP9_9367;MMS22L_33129;MKI67_9232;MCM3_9207;KIF22_8963 105.96730003879972 86.3883 2.71598E-7 108.00298305262915 72.8738680655473 80.79830356101506 55.16449718165685 26.6888 2.71598E-7 60.696759010917 37.926846826123786 48.51047712417782 260.71135718165704 240.486 2.71599E-7 239.92502446120508 181.699122872614 175.30844920203046 4.5 161.963 86.3883;2.71598E-7;292.216;126.653;21.9311;197.273;17.3097 26.6888;2.71598E-7;147.515;85.587;6.82654;116.413;3.12114 262.273;2.71599E-7;658.494;240.486;76.1794;496.915;90.6321 0 7 0 7 360243;299112;300795;313108;291234;316273;293502 TOP2A_10059;POLE2_9520;NS5ATP9_9367;MMS22L_33129;MKI67_9232;MCM3_9207;KIF22_8963 105.96730003879972 86.3883 108.00298305262915 55.16449718165685 26.6888 60.696759010917 260.71135718165704 240.486 239.92502446120508 86.3883;2.71598E-7;292.216;126.653;21.9311;197.273;17.3097 26.6888;2.71598E-7;147.515;85.587;6.82654;116.413;3.12114 262.273;2.71599E-7;658.494;240.486;76.1794;496.915;90.6321 0 Exp 2,1(0.15);Exp 4,2(0.29);Hill,2(0.29);Poly 2,2(0.29) 1.731749766935286 12.1727055311203 1.540663719177246 1.9603345394134521 0.17171738675520834 1.6661498546600342 25.957570515893224 185.9770295617062 10.199708857115404 100.1292855061983 82.97241173453452 438.45030262877947 DOWN 0.0 1.0 0.0 GO:0071549 7 cellular response to dexamethasone stimulus 35 36 6 6 3 6 3 3 65 33 2446 0.98561 0.06946 0.06946 8.33 362282;29221;170913 pck1;arg1;abcb1a PCK1_9439;ARG1_33267;ABCB1A_7938 499.051 529.244 206.982 278.2040235025367 463.2180348335389 322.4093552762258 296.1716666666667 356.883 118.025 156.86484366273186 261.010194512947 175.57680934720386 1730.8466666666664 1531.55 1021.06 827.6317962918868 1936.1620237361283 736.9569392625341 0.5 368.113 529.244;760.927;206.982 356.883;413.607;118.025 1021.06;2639.93;1531.55 1 2 1 362282 PCK1_9439 529.244 529.244 356.883 356.883 1021.06 1021.06 529.244 356.883 1021.06 2 29221;170913 ARG1_33267;ABCB1A_7938 483.9545 483.9545 391.6982659043821 265.81600000000003 265.81600000000003 209.00803659668208 2085.74 2085.74 783.7430141315464 760.927;206.982 413.607;118.025 2639.93;1531.55 0 Exp 2,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 1.6635486782126652 5.012513875961304 1.513624906539917 1.8874764442443848 0.1938808388390274 1.611412525177002 184.23351099669992 813.8684890033002 118.66238562513564 473.6809477081977 794.2931235237997 2667.4002098095334 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0051281 11 positive regulation of release of sequestered calcium ion into cytosol 12 13 4 4 3 3 3 3 65 10 2469 0.99972 0.0042981 0.0042981 23.08 24832;245920;686019 thy1;cxcl10;casq1 THY1_33010;CXCL10_8408;CASQ1_32992 272.72933333333526 147.66 5.72311E-12 352.3261320159658 165.0431421446398 221.14351318911832 157.13476666666858 96.6023 5.72311E-12 194.59514238942975 101.51246809405197 122.78713329404198 747.0243333333352 285.773 5.72313E-12 1056.108004361452 385.9481828998945 661.3825853490176 0.0 5.72311E-12 0.5 73.83000000000285 5.72311E-12;670.528;147.66 5.72311E-12;374.802;96.6023 5.72313E-12;1955.3;285.773 0 3 0 3 24832;245920;686019 THY1_33010;CXCL10_8408;CASQ1_32992 272.72933333333526 147.66 352.3261320159658 157.13476666666858 96.6023 194.59514238942975 747.0243333333352 285.773 1056.108004361452 5.72311E-12;670.528;147.66 5.72311E-12;374.802;96.6023 5.72313E-12;1955.3;285.773 0 Exp 2,1(0.34);Hill,1(0.34);Poly 2,1(0.34) 2.0031389716358654 6.0440754890441895 1.8538048267364502 2.327066659927368 0.2705653563449985 1.863204002380371 -125.96521750410147 671.423884170772 -63.07036670273186 377.33990003606897 -448.0743782650146 1942.123044931685 DOWN 0.0 1.0 0.0 GO:0033043 6 regulation of organelle organization 271 282 17 17 13 14 11 11 57 271 2208 0.93371 0.12447 0.17083 3.9 684352;315852;360243;81687;291234;25283;361921;306575;29397;246142;81639 twf2;ttk;top2a;mmp9;mki67;gclc;ect2;ckap2;ccl11;bmf;alox15 TWF2_10109;TTK_32727;TOP2A_10059;MMP9_32531;MKI67_9232;GCLC_8699;ECT2_8523;CKAP2_8324;CCL11_33230;BMF_8152;ALOX15_8036 341.7305636363636 131.7 10.0162 375.571397494139 300.58910050240644 358.6995677187457 193.48567181818183 81.8286 3.29405 220.14252874788397 167.75316890179693 211.82245518957225 946.3115545454547 299.165 37.7305 1057.9324560317198 834.1626869148021 1010.4204900145978 138.399;737.351;86.3883;728.316;21.9311;131.7;10.0162;32.2386;986.476;119.401;766.819 90.7363;446.625;26.6888;443.137;6.82654;39.9158;3.29405;15.2683;552.974;81.8286;421.048 299.165;2108.09;262.273;2039.06;76.1794;397.209;37.7305;76.7052;2230.86;220.085;2662.07 1 10 1 29397 CCL11_33230 986.476 986.476 552.974 552.974 2230.86 2230.86 986.476 552.974 2230.86 10 684352;315852;360243;81687;291234;25283;361921;306575;246142;81639 TWF2_10109;TTK_32727;TOP2A_10059;MMP9_32531;MKI67_9232;GCLC_8699;ECT2_8523;CKAP2_8324;BMF_8152;ALOX15_8036 277.25602 125.5505 325.45223248651274 157.53683900000001 60.87219999999999 195.07043905166236 817.85671 280.71900000000005 1020.737186528628 138.399;737.351;86.3883;728.316;21.9311;131.7;10.0162;32.2386;119.401;766.819 90.7363;446.625;26.6888;443.137;6.82654;39.9158;3.29405;15.2683;81.8286;421.048 299.165;2108.09;262.273;2039.06;76.1794;397.209;37.7305;76.7052;220.085;2662.07 0 Exp 2,1(0.1);Exp 4,4(0.37);Hill,1(0.1);Linear,2(0.19);Poly 2,2(0.19);Power,1(0.1) 1.8056206047652261 19.99528682231903 1.5021449327468872 2.0582168102264404 0.21638419957265448 1.922041654586792 119.78205103128485 563.6790762414425 63.38975092879579 323.5815927075679 321.11342545591856 1571.5096836349906 DOWN 0.09090909090909091 0.9090909090909091 0.0 GO:0032879 4 regulation of localization 652 690 48 45 30 30 22 22 46 668 1811 0.86945 0.19573 0.33375 3.19 688621;24832;25682;25154;81687;24426;25283;81919;24367;309186;361921;245920;84032;24854;113902;29397;686019;24232;29657;29221;81639;170913 tslp;thy1;ppard;pgr;mmp9;gstp1;gclc;fut1;fgg;fermt3;ect2;cxcl10;col3a1;clu;ces1d;ccl11;casq1;c3;arntl;arg1;alox15;abcb1a TSLP_32811;THY1_33010;PPARD_9536;PGR_32824;MMP9_32531;GSTP1_8762;GCLC_8699;FUT1_8668;FGG_8639;FERMT3_32542;ECT2_8523;CXCL10_8408;COL3A1_8354;CLU_32773;CES1D_32914;CCL11_33230;CASQ1_32992;C3_8175;ARNTL_8086;ARG1_33267;ALOX15_8036;ABCB1A_7938 335.7279863636366 223.68099999999998 5.72311E-12 327.89215841501203 334.0912748074424 320.52309096756574 200.018872727273 118.9175 5.72311E-12 220.31161472133437 196.02498438177844 213.64532456151306 979.3312318181819 771.043 5.72313E-12 907.7978254395473 968.6989710358341 902.7109106512296 344.675;5.72311E-12;94.1074;283.618;728.316;14.7631;131.7;240.861;42.4612;539.113;10.0162;670.528;212.603;935.649;11.0684;986.476;147.66;234.759;22.9134;760.927;766.819;206.982 244.2;5.72311E-12;37.7692;138.711;443.137;9.42992;39.9158;78.9726;20.6424;334.248;3.29405;374.802;119.81;808.484;4.18343;552.974;96.6023;129.148;11.4115;413.607;421.048;118.025 560.435;5.72313E-12;148.485;1554.21;2039.06;25.7196;397.209;847.87;98.0534;1187.86;37.7305;1955.3;1510.69;1071.05;17.0564;2230.86;285.773;694.216;50.1592;2639.93;2662.07;1531.55 2 20 2 24426;29397 GSTP1_8762;CCL11_33230 500.61955 500.61955 687.1047809564456 281.20196000000004 281.20196000000004 384.3437048418033 1128.2898 1128.2898 1559.2697303084162 14.7631;986.476 9.42992;552.974 25.7196;2230.86 20 688621;24832;25682;25154;81687;25283;81919;24367;309186;361921;245920;84032;24854;113902;686019;24232;29657;29221;81639;170913 TSLP_32811;THY1_33010;PPARD_9536;PGR_32824;MMP9_32531;GCLC_8699;FUT1_8668;FGG_8639;FERMT3_32542;ECT2_8523;CXCL10_8408;COL3A1_8354;CLU_32773;CES1D_32914;CASQ1_32992;C3_8175;ARNTL_8086;ARG1_33267;ALOX15_8036;ABCB1A_7938 319.2388300000003 223.68099999999998 301.3870860808125 191.90056400000032 118.9175 212.38764828070285 964.435375 771.043 883.3517984417616 344.675;5.72311E-12;94.1074;283.618;728.316;131.7;240.861;42.4612;539.113;10.0162;670.528;212.603;935.649;11.0684;147.66;234.759;22.9134;760.927;766.819;206.982 244.2;5.72311E-12;37.7692;138.711;443.137;39.9158;78.9726;20.6424;334.248;3.29405;374.802;119.81;808.484;4.18343;96.6023;129.148;11.4115;413.607;421.048;118.025 560.435;5.72313E-12;148.485;1554.21;2039.06;397.209;847.87;98.0534;1187.86;37.7305;1955.3;1510.69;1071.05;17.0564;285.773;694.216;50.1592;2639.93;2662.07;1531.55 0 Exp 2,6(0.28);Exp 4,4(0.19);Exp 5,2(0.1);Hill,2(0.1);Linear,1(0.05);Poly 2,6(0.28);Power,1(0.05) 1.9442732274546686 44.29378402233124 1.5021449327468872 3.5281898975372314 0.5984248972693875 1.8585044145584106 198.71057396315965 472.7453987641137 107.95650833037551 292.08123712417046 599.9866643062195 1358.6757993301449 DOWN 0.09090909090909091 0.9090909090909091 0.0 GO:0009067 8 aspartate family amino acid biosynthetic process 9 9 2 2 2 2 2 2 66 7 2472 0.99864 0.022402 0.022402 22.22 288583;25612 plod3;asns PLOD3_9507;ASNS_8091 536.8870000000001 536.8870000000001 191.145 488.95302548199857 333.70058721203577 395.6079175708165 369.6205 369.6205 113.564 362.11857503378644 219.14065749882465 292.98719491838364 808.1435 808.1435 510.267 421.2609862122292 633.0867886694875 340.83883895587803 0.0 191.145 0.0 191.145 882.629;191.145 625.677;113.564 1106.02;510.267 0 2 0 2 288583;25612 PLOD3_9507;ASNS_8091 536.8870000000001 536.8870000000001 488.95302548199857 369.6205 369.6205 362.11857503378644 808.1435 808.1435 421.2609862122292 882.629;191.145 625.677;113.564 1106.02;510.267 0 Poly 2,2(1) 1.7601586372964215 3.5214500427246094 1.7160688638687134 1.805381178855896 0.06315334357090575 1.7607250213623047 -140.76732000000004 1214.5413199999998 -132.25024000000002 871.4912400000001 224.30556000000013 1391.98144 DOWN 0.0 1.0 0.0 GO:0002244 5 hematopoietic progenitor cell differentiation 30 31 4 4 3 2 2 2 66 29 2450 0.95198 0.19985 0.19985 6.45 360243;362376 top2a;herc6 TOP2A_10059;HERC6_8794 63.037400000000005 63.037400000000005 39.6865 33.02315947361788 67.46154703268802 32.425035199461504 21.23085 21.23085 15.7729 7.718706912754238 22.26493319581085 7.578903633988445 209.84000000000003 209.84000000000003 157.407 74.15145971590843 219.77414820691848 72.80840869574027 0.5 63.037400000000005 86.3883;39.6865 26.6888;15.7729 262.273;157.407 0 2 0 2 360243;362376 TOP2A_10059;HERC6_8794 63.037400000000005 63.037400000000005 33.02315947361788 21.23085 21.23085 7.718706912754238 209.84000000000003 209.84000000000003 74.15145971590843 86.3883;39.6865 26.6888;15.7729 262.273;157.407 0 Exp 4,2(1) 1.8666283635309109 3.7377359867095947 1.7774014472961426 1.9603345394134521 0.12935322993957296 1.8688679933547974 17.269636000000013 108.80516399999999 10.533268000000001 31.928432 107.07132000000004 312.60868000000005 DOWN 0.0 1.0 0.0 GO:0007566 3 embryo implantation 18 18 4 4 3 3 2 2 66 16 2463 0.98885 0.081657 0.081657 11.11 25682;81687 ppard;mmp9 PPARD_9536;MMP9_32531 411.2117 411.2117 94.1074 448.45320174682666 493.76278662295084 432.9906585039914 240.4531 240.4531 37.7692 286.6383202546721 293.2173677377049 276.7551096883806 1093.7725 1093.7725 148.485 1336.8384028417568 1339.8571803278687 1290.7445818318824 0.0 94.1074 0.5 411.2117 94.1074;728.316 37.7692;443.137 148.485;2039.06 0 2 0 2 25682;81687 PPARD_9536;MMP9_32531 411.2117 411.2117 448.45320174682666 240.4531 240.4531 286.6383202546721 1093.7725 1093.7725 1336.8384028417568 94.1074;728.316 37.7692;443.137 148.485;2039.06 0 Exp 5,1(0.5);Linear,1(0.5) 1.994330484895412 3.9902456998825073 1.9388991594314575 2.05134654045105 0.07951230564562117 1.9951228499412537 -210.31272799999994 1032.736128 -156.8073439999999 637.713544 -758.9909999999995 2946.5359999999996 DOWN 0.0 1.0 0.0 GO:1901565 5 organonitrogen compound catabolic process 128 143 5 5 4 5 4 4 64 139 2340 0.66613 0.53715 0.79091 2.8 156275;116599;29657;29221 ggt7;blvra;arntl;arg1 GGT7_33026;BLVRA_8151;ARNTL_8086;ARG1_33267 327.3601 262.8 22.9134 334.63364440460356 433.5690880165289 350.3809886753149 185.60002500000002 158.6908 11.4115 197.68966087802661 238.37505574539097 203.82289061229395 939.2760499999999 533.5074999999999 50.1592 1166.5207880021155 1354.5053633026064 1281.868463207719 109.609;415.991;22.9134;760.927 29.3336;288.048;11.4115;413.607 346.073;720.942;50.1592;2639.93 0 4 0 4 156275;116599;29657;29221 GGT7_33026;BLVRA_8151;ARNTL_8086;ARG1_33267 327.3601 262.8 334.63364440460356 185.60002500000002 158.6908 197.68966087802661 939.2760499999999 533.5074999999999 1166.5207880021155 109.609;415.991;22.9134;760.927 29.3336;288.048;11.4115;413.607 346.073;720.942;50.1592;2639.93 0 Exp 2,2(0.5);Exp 4,2(0.5) 1.993212118519589 8.456044554710388 1.513624906539917 3.442979335784912 0.9050976999940031 1.7497201561927795 -0.5808715165114791 655.3010715165115 -8.135842660466068 379.33589266046613 -203.91432224207324 2082.4664222420733 DOWN 0.0 1.0 0.0 GO:0048639 6 positive regulation of developmental growth 48 50 4 4 3 3 3 3 65 47 2432 0.95739 0.14723 0.14723 6.0 684352;25682;24232 twf2;ppard;c3 TWF2_10109;PPARD_9536;C3_8175 155.75513333333333 138.399 94.1074 71.91414790466013 144.62124080859127 68.74223247219126 85.8845 90.7363 37.7692 45.88219965073598 78.53894232469993 45.73660429558011 380.622 299.165 148.485 281.83685569314747 337.52035775952834 267.9414642891329 1.5 186.579 138.399;94.1074;234.759 90.7363;37.7692;129.148 299.165;148.485;694.216 0 3 0 3 684352;25682;24232 TWF2_10109;PPARD_9536;C3_8175 155.75513333333333 138.399 71.91414790466013 85.8845 90.7363 45.88219965073598 380.622 299.165 281.83685569314747 138.399;94.1074;234.759 90.7363;37.7692;129.148 299.165;148.485;694.216 0 Exp 5,1(0.34);Poly 2,2(0.67) 1.7524815613966898 5.280319094657898 1.5467612743377686 1.9388991594314575 0.19833916935575727 1.7946586608886719 74.37661413678907 237.1336525298776 33.96390337404539 137.8050966259546 61.693574376087156 699.5504256239128 DOWN 0.0 1.0 0.0 GO:0050794 4 regulation of cellular process 1555 1680 102 99 68 63 46 46 22 1634 845 0.66132 0.43846 0.89687 2.74 684352;315852;688621;360243;24832;25671;295703;25682;363131;25154;362282;304545;300795;338475;259241;24314;316351;81687;291234;24426;25283;81919;24367;309186;29243;361921;64191;312495;24296;245920;84032;24854;306575;170945;113902;114494;29397;686019;24232;246142;25612;29657;29221;81639;252898;170913 twf2;ttk;tslp;top2a;thy1;smad1;serping1;ppard;pik3r4;pgr;pck1;oasl;pclaf;nrep;nr1d2;nqo1;npas2;mmp9;mki67;gstp1;gclc;fut1;fgg;fermt3;f10;ect2;dhcr7;cyp26b1;cyp1a1;cxcl10;col3a1;clu;ckap2;chrna2;ces1d;ccna2;ccl11;casq1;c3;bmf;asns;arntl;arg1;alox15;acox2;abcb1a TWF2_10109;TTK_32727;TSLP_32811;TOP2A_10059;THY1_33010;SMAD1_32578;SERPING1_32597;PPARD_9536;PIK3R4_9484;PGR_32824;PCK1_9439;OASL_9389;NS5ATP9_9367;NREP_9364;NR1D2_9358;NQO1_33055;NPAS2_9350;MMP9_32531;MKI67_9232;GSTP1_8762;GCLC_8699;FUT1_8668;FGG_8639;FERMT3_32542;F10_8585;ECT2_8523;DHCR7_8466;CYP26B1_8418;CYP1A1_8415;CXCL10_8408;COL3A1_8354;CLU_32773;CKAP2_8324;CHRNA2_32401;CES1D_32914;CCNA2_8221;CCL11_33230;CASQ1_32992;C3_8175;BMF_8152;ASNS_8091;ARNTL_8086;ARG1_33267;ALOX15_8036;ACOX2_32902;ABCB1A_7938 260.3616021739132 135.0495 5.72311E-12 303.70667072223875 232.7048542039242 280.87315869972315 155.75550130434797 64.94065 5.72311E-12 205.75707375382808 134.46214907108066 185.44670788249476 703.4809282608697 292.46900000000005 5.72313E-12 809.6575942017834 647.1754244499035 783.8934680179079 138.399;737.351;344.675;86.3883;5.72311E-12;21.9973;32.3997;94.1074;955.628;283.618;529.244;76.6126;292.216;61.543;29.1728;25.6813;21.0878;728.316;21.9311;14.7631;131.7;240.861;42.4612;539.113;104.19;10.0162;161.702;18.1872;12.8863;670.528;212.603;935.649;32.2386;163.479;11.0684;14.384;986.476;147.66;234.759;119.401;191.145;22.9134;760.927;766.819;743.353;206.982 90.7363;446.625;244.2;26.6888;5.72311E-12;5.02186;13.7308;37.7692;735.228;138.711;356.883;28.4477;147.515;25.6719;3.35457;7.73944;11.3305;443.137;6.82654;9.42992;39.9158;78.9726;20.6424;334.248;38.4229;3.29405;50.9087;10.0176;9.13136;374.802;119.81;808.484;15.2683;101.968;4.18343;4.89199;552.974;96.6023;129.148;81.8286;113.564;11.4115;413.607;421.048;432.537;118.025 299.165;2108.09;560.435;262.273;5.72313E-12;80.1461;99.4885;148.485;1288.97;1554.21;1021.06;260.389;658.494;148.788;114.038;86.1211;43.5624;2039.06;76.1794;25.7196;397.209;847.87;98.0534;1187.86;163.044;37.7305;481.517;36.7271;19.3234;1955.3;1510.69;1071.05;76.7052;414.362;17.0564;58.2504;2230.86;285.773;694.216;220.085;510.267;50.1592;2639.93;2662.07;2287.79;1531.55 7 39 7 362282;259241;24314;24426;312495;24296;29397 PCK1_9439;NR1D2_9358;NQO1_33055;GSTP1_8762;CYP26B1_8418;CYP1A1_8415;CCL11_33230 230.91581428571428 25.6813 383.4502746171983 135.64712714285716 9.42992 225.3473349291568 504.8356 86.1211 842.4262838970759 529.244;29.1728;25.6813;14.7631;18.1872;12.8863;986.476 356.883;3.35457;7.73944;9.42992;10.0176;9.13136;552.974 1021.06;114.038;86.1211;25.7196;36.7271;19.3234;2230.86 39 684352;315852;688621;360243;24832;25671;295703;25682;363131;25154;304545;300795;338475;316351;81687;291234;25283;81919;24367;309186;29243;361921;64191;245920;84032;24854;306575;170945;113902;114494;686019;24232;246142;25612;29657;29221;81639;252898;170913 TWF2_10109;TTK_32727;TSLP_32811;TOP2A_10059;THY1_33010;SMAD1_32578;SERPING1_32597;PPARD_9536;PIK3R4_9484;PGR_32824;OASL_9389;NS5ATP9_9367;NREP_9364;NPAS2_9350;MMP9_32531;MKI67_9232;GCLC_8699;FUT1_8668;FGG_8639;FERMT3_32542;F10_8585;ECT2_8523;DHCR7_8466;CXCL10_8408;COL3A1_8354;CLU_32773;CKAP2_8324;CHRNA2_32401;CES1D_32914;CCNA2_8221;CASQ1_32992;C3_8175;BMF_8152;ASNS_8091;ARNTL_8086;ARG1_33267;ALOX15_8036;ACOX2_32902;ABCB1A_7938 265.6467435897437 147.66 292.95836542646845 159.36469666666682 81.8286 205.00910265380378 739.1352179487182 397.209 809.73767615055 138.399;737.351;344.675;86.3883;5.72311E-12;21.9973;32.3997;94.1074;955.628;283.618;76.6126;292.216;61.543;21.0878;728.316;21.9311;131.7;240.861;42.4612;539.113;104.19;10.0162;161.702;670.528;212.603;935.649;32.2386;163.479;11.0684;14.384;147.66;234.759;119.401;191.145;22.9134;760.927;766.819;743.353;206.982 90.7363;446.625;244.2;26.6888;5.72311E-12;5.02186;13.7308;37.7692;735.228;138.711;28.4477;147.515;25.6719;11.3305;443.137;6.82654;39.9158;78.9726;20.6424;334.248;38.4229;3.29405;50.9087;374.802;119.81;808.484;15.2683;101.968;4.18343;4.89199;96.6023;129.148;81.8286;113.564;11.4115;413.607;421.048;432.537;118.025 299.165;2108.09;560.435;262.273;5.72313E-12;80.1461;99.4885;148.485;1288.97;1554.21;260.389;658.494;148.788;43.5624;2039.06;76.1794;397.209;847.87;98.0534;1187.86;163.044;37.7305;481.517;1955.3;1510.69;1071.05;76.7052;414.362;17.0564;58.2504;285.773;694.216;220.085;510.267;50.1592;2639.93;2662.07;2287.79;1531.55 0 Exp 2,8(0.18);Exp 4,17(0.37);Exp 5,3(0.07);Hill,3(0.07);Linear,3(0.07);Poly 2,11(0.24);Power,1(0.03) 1.9653761810490973 102.10889422893524 1.5018656253814697 15.48720932006836 2.0567141987224917 1.7966456413269043 172.5945551419001 348.1286492059263 96.29453942828312 215.21646318041277 469.501029231503 937.460827290236 DOWN 0.15217391304347827 0.8478260869565217 0.0 GO:0048232 5 male gamete generation 67 75 7 6 4 4 3 3 65 72 2407 0.86196 0.32383 0.45128 4.0 312495;24854;29657 cyp26b1;clu;arntl CYP26B1_8418;CLU_32773;ARNTL_8086 325.5832 22.9134 18.1872 528.3377655334133 329.30243185133725 531.3166660157783 276.6377 11.4115 10.0176 460.59293400688426 280.50021902570336 462.6484469965879 385.9787666666666 50.1592 36.7271 593.3271031928706 388.30714116012496 598.2762207368579 18.1872;935.649;22.9134 10.0176;808.484;11.4115 36.7271;1071.05;50.1592 1 2 1 312495 CYP26B1_8418 18.1872 18.1872 10.0176 10.0176 36.7271 36.7271 18.1872 10.0176 36.7271 2 24854;29657 CLU_32773;ARNTL_8086 479.2812 479.2812 645.4015321903721 409.94775000000004 409.94775000000004 563.6153698473145 560.6046 560.6046 721.8788075309593 935.649;22.9134 808.484;11.4115 1071.05;50.1592 0 Exp 4,2(0.67);Poly 2,1(0.34) 2.2367310669404525 7.088173270225525 1.5548590421676636 3.442979335784912 0.9730861232678784 2.090334892272949 -272.28726426137257 923.4536642613726 -244.5722706939997 797.8476706939997 -285.43405631530663 1057.3915896486399 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0006139 4 nucleobase-containing compound metabolic process 359 401 16 16 12 11 9 9 59 392 2087 0.35375 0.76657 0.7352 2.24 360243;25682;299112;362282;300795;313108;291234;316273;293502 top2a;ppard;pole2;pck1;pclaf;mms22l;mki67;mcm3;kif22 TOP2A_10059;PPARD_9536;POLE2_9520;PCK1_9439;NS5ATP9_9367;MMS22L_33129;MKI67_9232;MCM3_9207;KIF22_8963 151.68027780795535 94.1074 2.71598E-7 169.7367818932683 86.11249087584252 106.6246464110079 86.75596447462199 37.7692 2.71598E-7 114.26889525481897 45.95039047901385 69.55122998270005 332.72494447462213 240.486 2.71599E-7 333.4357710386302 200.12622734589374 214.82642296615043 86.3883;94.1074;2.71598E-7;529.244;292.216;126.653;21.9311;197.273;17.3097 26.6888;37.7692;2.71598E-7;356.883;147.515;85.587;6.82654;116.413;3.12114 262.273;148.485;2.71599E-7;1021.06;658.494;240.486;76.1794;496.915;90.6321 1 8 1 362282 PCK1_9439 529.244 529.244 356.883 356.883 1021.06 1021.06 529.244 356.883 1021.06 8 360243;25682;299112;300795;313108;291234;316273;293502 TOP2A_10059;PPARD_9536;POLE2_9520;NS5ATP9_9367;MMS22L_33129;MKI67_9232;MCM3_9207;KIF22_8963 104.48481253394975 90.24785 100.07921231626834 52.99008503394975 32.229 56.52982922456502 246.6830625339499 194.4855 225.6433706464191 86.3883;94.1074;2.71598E-7;292.216;126.653;21.9311;197.273;17.3097 26.6888;37.7692;2.71598E-7;147.515;85.587;6.82654;116.413;3.12114 262.273;148.485;2.71599E-7;658.494;240.486;76.1794;496.915;90.6321 0 Exp 2,1(0.12);Exp 4,2(0.23);Exp 5,1(0.12);Hill,2(0.23);Linear,1(0.12);Poly 2,2(0.23) 1.7396504404911237 15.72301721572876 1.540663719177246 1.9603345394134521 0.1705077491128208 1.6661498546600342 40.7855803043534 262.5749753115573 12.100286241473597 161.4116427077704 114.88024072938376 550.5696482198605 DOWN 0.1111111111111111 0.8888888888888888 0.0 GO:0034605 5 cellular response to heat 21 23 4 4 3 3 2 2 66 21 2458 0.978 0.12414 0.12414 8.7 291234;245920 mki67;cxcl10 MKI67_9232;CXCL10_8408 346.22955 346.22955 21.9311 458.62726624657313 168.7754236607143 383.8737232933854 190.81427000000002 190.81427000000002 6.82654 260.1979430762392 90.1373105994898 217.78721099468135 1015.7397 1015.7397 76.1794 1328.7389189273338 501.61805624999994 1112.1623017922232 0.5 346.22955 21.9311;670.528 6.82654;374.802 76.1794;1955.3 0 2 0 2 291234;245920 MKI67_9232;CXCL10_8408 346.22955 346.22955 458.62726624657313 190.81427000000002 190.81427000000002 260.1979430762392 1015.7397 1015.7397 1328.7389189273338 21.9311;670.528 6.82654;374.802 76.1794;1955.3 0 Exp 2,1(0.5);Exp 4,1(0.5) 1.887614922716365 3.775846481323242 1.8538048267364502 1.922041654586792 0.04825072369963575 1.887923240661621 -289.39541199999985 981.8545119999999 -169.8016808 551.4302208 -825.798488 2857.277888 DOWN 0.0 1.0 0.0 GO:0045785 6 positive regulation of cell adhesion 137 145 10 10 5 6 4 4 64 141 2338 0.6553 0.54842 0.79359 2.76 24832;81919;24367;81639 thy1;fut1;fgg;alox15 THY1_33010;FUT1_8668;FGG_8639;ALOX15_8036 262.5353000000014 141.6611 5.72311E-12 352.1974912853473 260.773428208879 325.1118948919806 130.16575000000142 49.8075 5.72311E-12 196.7838989350742 124.05247294390999 182.95328932333683 901.9983500000014 472.9617 5.72313E-12 1232.9788586239235 894.7716038799044 1141.6625457147047 5.72311E-12;240.861;42.4612;766.819 5.72311E-12;78.9726;20.6424;421.048 5.72313E-12;847.87;98.0534;2662.07 0 4 0 4 24832;81919;24367;81639 THY1_33010;FUT1_8668;FGG_8639;ALOX15_8036 262.5353000000014 141.6611 352.1974912853473 130.16575000000142 49.8075 196.7838989350742 901.9983500000014 472.9617 1232.9788586239235 5.72311E-12;240.861;42.4612;766.819 5.72311E-12;78.9726;20.6424;421.048 5.72313E-12;847.87;98.0534;2662.07 0 Exp 2,2(0.5);Exp 4,1(0.25);Hill,1(0.25) 2.1554274321341467 8.919995665550232 1.5021449327468872 2.8176381587982178 0.6497919154539269 2.3001062870025635 -82.61824145963897 607.6888414596418 -62.682470956371304 323.0139709563741 -306.3209314514436 2110.3176314514467 DOWN 0.0 1.0 0.0 GO:1904093 8 negative regulation of autophagic cell death 1 1 1 1 1 1 1 1 67 0 2479 1.0 0.026698 0.026698 100.0 246142 bmf BMF_8152 119.401 119.401 119.401 119.401 81.8286 81.8286 81.8286 81.8286 220.085 220.085 220.085 220.08500000000004 0.0 119.401 0.0 119.401 119.401 81.8286 220.085 0 1 0 1 246142 BMF_8152 119.401 119.401 81.8286 81.8286 220.085 220.085 119.401 81.8286 220.085 0 Poly 2,1(1) 1.6033858060836792 1.6033858060836792 1.6033858060836792 1.6033858060836792 0.0 1.6033858060836792 119.401 119.401 81.8286 81.8286 220.085 220.085 DOWN 0.0 1.0 0.0 GO:0048247 7 lymphocyte chemotaxis 19 19 4 4 3 3 2 2 66 17 2462 0.98701 0.089736 0.089736 10.53 245920;29397 cxcl10;ccl11 CXCL10_8408;CCL11_33230 828.502 828.502 670.528 223.4089733023279 914.7729218475308 187.15294664833408 463.88800000000003 463.88800000000003 374.802 125.98662941756947 512.5386092376538 105.54083206802163 2093.08 2093.08 1955.3 194.85034462376981 2168.3228096531884 163.22896798972315 0.0 670.528 0.5 828.502 670.528;986.476 374.802;552.974 1955.3;2230.86 1 1 1 29397 CCL11_33230 986.476 986.476 552.974 552.974 2230.86 2230.86 986.476 552.974 2230.86 1 245920 CXCL10_8408 670.528 670.528 374.802 374.802 1955.3 1955.3 670.528 374.802 1955.3 0 Exp 2,1(0.5);Power,1(0.5) 1.9165789789699124 3.835283637046814 1.8538048267364502 1.9814788103103638 0.09027913956621417 1.917641818523407 518.8729599999999 1138.13104 289.27944 638.49656 1823.0312 2363.1288 CONFLICT 0.5 0.5 0.0 GO:0006959 4 humoral immune response 62 73 6 6 5 6 5 5 63 68 2411 0.98792 0.043291 0.043291 6.85 688621;295703;245920;29397;24232 tslp;serping1;cxcl10;ccl11;c3 TSLP_32811;SERPING1_32597;CXCL10_8408;CCL11_33230;C3_8175 453.76754 344.675 32.3997 376.8886373445849 471.63434515507083 388.40171300913505 262.97096 244.2 13.7308 210.35062136587095 280.82824945739 213.58740422600653 1108.0599 694.216 99.4885 930.9768962188589 1051.5867022530713 931.5143940417894 2.5 507.6015 344.675;32.3997;670.528;986.476;234.759 244.2;13.7308;374.802;552.974;129.148 560.435;99.4885;1955.3;2230.86;694.216 1 4 1 29397 CCL11_33230 986.476 986.476 552.974 552.974 2230.86 2230.86 986.476 552.974 2230.86 4 688621;295703;245920;24232 TSLP_32811;SERPING1_32597;CXCL10_8408;C3_8175 320.590425 289.717 266.74413498292546 190.4702 186.67399999999998 154.77115539238358 827.359875 627.3254999999999 793.9399314963291 344.675;32.3997;670.528;234.759 244.2;13.7308;374.802;129.148 560.435;99.4885;1955.3;694.216 0 Exp 2,2(0.4);Exp 4,1(0.2);Poly 2,1(0.2);Power,1(0.2) 1.7509770081108784 8.786224603652954 1.5467612743377686 1.9814788103103638 0.16622186486828333 1.7183171510696411 123.41008368449502 784.124996315505 78.59051091450439 447.35140908549556 292.0226708325629 1924.097129167437 DOWN 0.2 0.8 0.0 GO:0060341 5 regulation of cellular localization 248 267 14 14 9 7 4 4 64 263 2216 0.14341 0.93773 0.31212 1.5 24832;361921;245920;686019 thy1;ect2;cxcl10;casq1 THY1_33010;ECT2_8523;CXCL10_8408;CASQ1_32992 207.05105000000142 78.8381 5.72311E-12 316.24413007570996 116.3448484386463 191.62285627371708 118.67458750000144 49.948175 5.72311E-12 176.52645076731 70.65931892195765 109.37527530153378 569.7008750000014 161.75175000000002 5.72313E-12 932.3896789533478 276.56328011533105 549.105095813034 5.72311E-12;10.0162;670.528;147.66 5.72311E-12;3.29405;374.802;96.6023 5.72313E-12;37.7305;1955.3;285.773 0 4 0 4 24832;361921;245920;686019 THY1_33010;ECT2_8523;CXCL10_8408;CASQ1_32992 207.05105000000142 78.8381 316.24413007570996 118.67458750000144 49.948175 176.52645076731 569.7008750000014 161.75175000000002 932.3896789533478 5.72311E-12;10.0162;670.528;147.66 5.72311E-12;3.29405;374.802;96.6023 5.72313E-12;37.7305;1955.3;285.773 0 Exp 2,1(0.25);Exp 4,1(0.25);Hill,1(0.25);Poly 2,1(0.25) 1.9042247757373785 7.679910898208618 1.6358354091644287 2.327066659927368 0.29100994521000434 1.8585044145584106 -102.86819747419429 516.9702974741972 -54.32133425196233 291.6705092519652 -344.0410103742794 1483.4427603742824 DOWN 0.0 1.0 0.0 GO:0031099 4 regeneration 111 120 11 11 6 8 5 5 63 115 2364 0.90197 0.21447 0.25038 4.17 116669;338475;291234;24426;114494 vwf;nrep;mki67;gstp1;ccna2 VWF_32396;NREP_9364;MKI67_9232;GSTP1_8762;CCNA2_8221 26.459520000000005 19.6764 14.384 19.874558470743438 25.126802925366583 18.076711113193557 10.187358 6.82654 4.11644 8.89574081401993 8.83919910227813 8.444240358223249 80.60308 76.1794 25.7196 45.72243543723366 84.27281367608879 39.5654137054194 19.6764;61.543;21.9311;14.7631;14.384 4.11644;25.6719;6.82654;9.42992;4.89199 94.078;148.788;76.1794;25.7196;58.2504 1 4 1 24426 GSTP1_8762 14.7631 14.7631 9.42992 9.42992 25.7196 25.7196 14.7631 9.42992 25.7196 4 116669;338475;291234;114494 VWF_32396;NREP_9364;MKI67_9232;CCNA2_8221 29.383625000000002 20.80375 21.67167503607339 10.3767175 5.859265 10.260274169762312 94.32395 85.12870000000001 39.14468434798438 19.6764;61.543;21.9311;14.384 4.11644;25.6719;6.82654;4.89199 94.078;148.788;76.1794;58.2504 0 Exp 4,4(0.8);Hill,1(0.2) 2.103810815830225 10.954686999320984 1.6267951726913452 3.5281898975372314 0.7668782344536446 1.922041654586792 9.038701404756377 43.88033859524363 2.389897381215791 17.98481861878421 40.52559829607608 120.6805617039239 DOWN 0.2 0.8 0.0 GO:0097435 5 supramolecular fiber organization 101 107 6 5 4 6 4 4 64 103 2376 0.8453 0.31938 0.53043 3.74 684352;288583;84032;29397 twf2;plod3;col3a1;ccl11 TWF2_10109;PLOD3_9507;COL3A1_8354;CCL11_33230 555.02675 547.616 138.399 441.3254264767856 594.4495387811635 455.71578869108924 347.299325 336.39200000000005 90.7363 281.28999310371705 355.40857378197813 271.34275914537193 1286.6837500000001 1308.355 299.165 806.1183253238426 1428.5073423496824 890.2312936800226 138.399;882.629;212.603;986.476 90.7363;625.677;119.81;552.974 299.165;1106.02;1510.69;2230.86 1 3 1 29397 CCL11_33230 986.476 986.476 552.974 552.974 2230.86 2230.86 986.476 552.974 2230.86 3 684352;288583;84032 TWF2_10109;PLOD3_9507;COL3A1_8354 411.2103333333334 212.603 409.94295684318485 278.7411 119.81 300.80676361998576 971.9583333333334 1106.02 616.7881356335687 138.399;882.629;212.603 90.7363;625.677;119.81 299.165;1106.02;1510.69 0 Poly 2,3(0.75);Power,1(0.25) 1.7712673449529899 7.1051918268203735 1.6129854917526245 1.9814788103103638 0.15570784927447612 1.7553637623786926 122.52783205275011 987.5256679472499 71.63513175835726 622.9635182416426 496.687791182634 2076.6797088173657 DOWN 0.25 0.75 0.0 GO:0097237 5 cellular response to toxic substance 71 80 6 6 5 5 4 4 64 76 2403 0.93988 0.16314 0.16314 5.0 24314;361921;29221;170913 nqo1;ect2;arg1;abcb1a NQO1_33055;ECT2_8523;ARG1_33267;ABCB1A_7938 250.901625 116.33165 10.0162 351.570191841576 221.00252927385733 332.4431631550408 135.66637250000002 62.882220000000004 3.29405 192.74330274718676 119.21792563448982 182.53018162938218 1073.8328999999999 808.83555 37.7305 1253.162380194711 973.543821461726 1212.7895011365458 3.0 760.927 25.6813;10.0162;760.927;206.982 7.73944;3.29405;413.607;118.025 86.1211;37.7305;2639.93;1531.55 1 3 1 24314 NQO1_33055 25.6813 25.6813 7.73944 7.73944 86.1211 86.1211 25.6813 7.73944 86.1211 3 361921;29221;170913 ECT2_8523;ARG1_33267;ABCB1A_7938 325.9750666666667 206.982 389.34081448675954 178.30868333333333 118.025 211.69499543352657 1403.0701666666664 1531.55 1305.848712573583 10.0162;760.927;206.982 3.29405;413.607;118.025 37.7305;2639.93;1531.55 0 Exp 2,1(0.25);Exp 4,1(0.25);Hill,1(0.25);Poly 2,1(0.25) 1.7851045223746131 7.209713935852051 1.513624906539917 2.1727771759033203 0.2918630204240472 1.7616559267044067 -93.63716300474437 595.4404130047444 -53.22206419224304 324.55480919224306 -154.2662325908168 2301.9320325908166 DOWN 0.25 0.75 0.0