Gene Ontology Analyses GO Category: BP GO File Creation Date: 07/15/20 Deduplicate Gene Sets: true Data Source: Kidney_2,3-Benzofluorene_Male Work Source: Kidney_2,3-Benzofluorene_Male_williams_0.05_NOMTC_foldfilter1.5_BMD BMDExpress2 Version: BMDExpress 2.30.0507 BETA Timestamp (Start Time): 02/12/2021 22:59.24 Remove Promiscuous Probes: true Remove BMD > Highest Dose from Category Descriptive Statistics: true Remove BMD with p-Value < Cutoff: 0.1 Remove genes with BMDU/BMDL >: 40.0 Identify conflicting probe sets: 0.5 Category Count: 2228 Total Run Time: 0 seconds GO/Pathway/Gene Set/Gene ID GO Level GO/Pathway/Gene Set/Gene Name All Genes (Expression Data) All Genes (Platform) Input Genes Genes with BMD <= Highest Dose Genes with BMD p-Value >= Genes with BMDU/BMDL <= Genes That Passed All Filters Fisher's A Parameter Fisher's B Parameter Fisher's C Parameter Fisher's D Parameter Fisher's Exact Left P-Value Fisher's Exact Right P-Value Fisher's Exact Two Tail Percentage Entrez Gene IDs Gene Symbols Probe IDs Genes with Conflicting Probesets BMD Mean BMD Median BMD Minimum BMD Standard Deviation BMD wMean BMD wSD BMDL Mean BMDL Median BMDL Minimum BMDL Standard Deviation BMDL wMean BMDL wSD BMDU Mean BMDU Median BMDU Minimum BMDU Standard Deviation BMDU wMean BMDU wSD 5th Percentile Index BMD at 5th Percentile of Total Genes 10th Percentile Index BMD at 10th Percentile of Total Genes BMD List BMDL List BMDU List Probes with Adverse Direction Up Probes with Adverse Direction Down Genes with Adverse Direction Up Genes Up List Genes Up Probes List Genes Up BMD Mean Genes Up BMD Median Genes Up SD Genes Up BMDL Mean Genes Up BMDL Median Genes Up BMDL SD Genes Up BMDU Mean Genes Up BMDU Median Genes Up BMDU SD BMD list (up) BMDL List (up) BMDU List (up) Genes with Adverse Direction Down Genes Down List Genes Down Probes List Genes Down BMD Mean Genes Down BMD Median Genes Down SD Genes Down BMDL Mean Genes Down BMDL Median Genes Down BMDL SD Genes Down BMDU Mean Genes Down BMDU Median Genes Down BMDU SD BMD list (down) BMDL List (down) BMDU List (down) Genes with Adverse Conflict Count Genes Conflict List Genes Conflict Probes List BMD list (Conflict) BMDL list (Conflict) BMDU list (Conflict) Model Counts Mean Fold Change Total Fold Change Min Fold Change Max Fold Change Standard Deviation Fold Change Median Fold Change Lower bound of the 95% confidence interval - BMD Upper bound of the 95% confidence interval - BMD Lower bound of the 95% confidence interval - BMDL Upper bound of the 95% confidence interval - BMDL Lower bound of the 95% confidence interval - BMDU Upper bound of the 95% confidence interval - BMDU Overall Direction Percent Genes With Overall Direction Up Percent Genes With Overall Direction Down Percent Genes With Overall Direction Conflict GO:0000070 6 mitotic sister chromatid segregation 13 13 4 4 1 2 0 0 38 13 2496 0.82211 1.0 1.0 0.0 0 0 0 0 0 GO:0000076 8 DNA replication checkpoint 6 7 2 1 1 0 0 0 38 7 2502 0.90001 1.0 1.0 0.0 0 0 0 0 0 GO:0000077 8 DNA damage checkpoint 17 18 1 1 1 0 0 0 38 18 2491 0.76224 1.0 1.0 0.0 0 0 0 0 0 GO:0000079 8 regulation of cyclin-dependent protein serine/threonine kinase activity 33 33 7 5 2 3 0 0 38 33 2476 0.607 1.0 1.0 0.0 0 0 0 0 0 GO:0000082 6 G1/S transition of mitotic cell cycle 23 25 1 1 1 0 0 0 38 25 2484 0.68551 1.0 1.0 0.0 0 0 0 0 0 GO:0000086 6 G2/M transition of mitotic cell cycle 16 16 3 3 1 2 0 0 38 16 2493 0.78566 1.0 1.0 0.0 0 0 0 0 0 GO:0000132 8 establishment of mitotic spindle orientation 8 8 1 1 0 1 0 0 38 8 2501 0.88655 1.0 1.0 0.0 0 0 0 0 0 GO:0000165 8 MAPK cascade 43 45 1 1 1 0 0 0 38 45 2464 0.50541 1.0 1.0 0.0 0 0 0 0 0 GO:0000209 10 protein polyubiquitination 28 29 1 1 0 0 0 0 38 29 2480 0.64509 1.0 1.0 0.0 0 0 0 0 0 GO:0000278 4 mitotic cell cycle 41 47 9 8 2 3 0 0 38 47 2462 0.49017 1.0 1.0 0.0 0 0 0 0 0 GO:0000288 9 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 1 1 1 1 1 0 0 0 38 1 2508 0.98508 1.0 1.0 0.0 0 0 0 0 0 GO:0000289 9 nuclear-transcribed mRNA poly(A) tail shortening 2 2 1 1 1 0 0 0 38 2 2507 0.97038 1.0 1.0 0.0 0 0 0 0 0 GO:0000320 4 re-entry into mitotic cell cycle 4 4 1 0 0 0 0 0 38 4 2505 0.94161 1.0 1.0 0.0 0 0 0 0 0 GO:0000731 7 DNA synthesis involved in DNA repair 7 7 1 1 1 0 0 0 38 7 2502 0.90001 1.0 1.0 0.0 0 0 0 0 0 GO:0000956 8 nuclear-transcribed mRNA catabolic process 15 16 1 1 1 0 0 0 38 16 2493 0.78566 1.0 1.0 0.0 0 0 0 0 0 GO:0001556 4 oocyte maturation 5 5 1 1 1 0 0 0 38 5 2504 0.92754 1.0 1.0 0.0 0 0 0 0 0 GO:0001701 7 in utero embryonic development 63 65 1 1 1 0 0 0 38 65 2444 0.3717 1.0 0.6245 0.0 0 0 0 0 0 GO:0001709 4 cell fate determination 9 10 1 1 0 0 0 0 38 10 2499 0.8602 1.0 1.0 0.0 0 0 0 0 0 GO:0001767 5 establishment of lymphocyte polarity 2 2 1 1 0 0 0 0 38 2 2507 0.97038 1.0 1.0 0.0 0 0 0 0 0 GO:0001768 6 establishment of T cell polarity 2 2 1 1 0 0 0 0 38 2 2507 0.97038 1.0 1.0 0.0 0 0 0 0 0 GO:0001818 6 negative regulation of cytokine production 68 69 2 2 1 1 0 0 38 69 2440 0.34944 1.0 0.62464 0.0 0 0 0 0 0 GO:0001835 5 blastocyst hatching 6 6 1 1 1 0 0 0 38 6 2503 0.91367 1.0 1.0 0.0 0 0 0 0 0 GO:0001890 5 placenta development 22 23 1 0 0 0 0 0 38 23 2486 0.70663 1.0 1.0 0.0 0 0 0 0 0 GO:0001936 7 regulation of endothelial cell proliferation 43 44 1 1 1 0 0 0 38 44 2465 0.5132 1.0 1.0 0.0 0 0 0 0 0 GO:0001938 8 positive regulation of endothelial cell proliferation 29 29 1 1 1 0 0 0 38 29 2480 0.64509 1.0 1.0 0.0 0 0 0 0 0 GO:0002042 9 cell migration involved in sprouting angiogenesis 9 9 1 1 1 0 0 0 38 9 2500 0.87328 1.0 1.0 0.0 0 0 0 0 0 GO:0002069 6 columnar/cuboidal epithelial cell maturation 3 4 1 1 1 0 0 0 38 4 2505 0.94161 1.0 1.0 0.0 0 0 0 0 0 GO:0002070 5 epithelial cell maturation 7 8 1 1 1 0 0 0 38 8 2501 0.88655 1.0 1.0 0.0 0 0 0 0 0 GO:0002082 6 regulation of oxidative phosphorylation 7 8 1 1 1 0 0 0 38 8 2501 0.88655 1.0 1.0 0.0 0 0 0 0 0 GO:0002521 5 leukocyte differentiation 80 87 1 1 1 0 0 0 38 87 2422 0.26433 1.0 0.63934 0.0 0 0 0 0 0 GO:0002523 6 leukocyte migration involved in inflammatory response 9 10 1 1 1 0 0 0 38 10 2499 0.8602 1.0 1.0 0.0 0 0 0 0 0 GO:0002526 6 acute inflammatory response 39 43 1 1 1 0 0 0 38 43 2466 0.52111 1.0 1.0 0.0 0 0 0 0 0 GO:0002544 6 chronic inflammatory response 13 14 1 1 1 0 0 0 38 14 2495 0.80978 1.0 1.0 0.0 0 0 0 0 0 GO:0002573 6 myeloid leukocyte differentiation 36 39 1 1 1 0 0 0 38 39 2470 0.55394 1.0 1.0 0.0 0 0 0 0 0 GO:0002791 7 regulation of peptide secretion 138 149 2 1 1 1 0 0 38 149 2360 0.099459 1.0 0.16706 0.0 0 0 0 0 0 GO:0002793 7 positive regulation of peptide secretion 97 104 2 1 1 1 0 0 38 104 2405 0.20269 1.0 0.4035 0.0 0 0 0 0 0 GO:0003002 4 regionalization 36 40 1 1 0 0 0 0 38 40 2469 0.54555 1.0 1.0 0.0 0 0 0 0 0 GO:0003014 4 renal system process 24 25 1 1 1 0 0 0 38 25 2484 0.68551 1.0 1.0 0.0 0 0 0 0 0 GO:0006022 5 aminoglycan metabolic process 23 24 1 1 0 1 0 0 38 24 2485 0.69599 1.0 1.0 0.0 0 0 0 0 0 GO:0006063 7 uronic acid metabolic process 3 10 1 1 0 1 0 0 38 10 2499 0.8602 1.0 1.0 0.0 0 0 0 0 0 GO:0006110 6 regulation of glycolytic process 22 23 1 0 0 0 0 0 38 23 2486 0.70663 1.0 1.0 0.0 0 0 0 0 0 GO:0006140 6 regulation of nucleotide metabolic process 30 33 1 0 0 0 0 0 38 33 2476 0.607 1.0 1.0 0.0 0 0 0 0 0 GO:0006260 6 DNA replication 28 29 2 2 2 0 0 0 38 29 2480 0.64509 1.0 1.0 0.0 0 0 0 0 0 GO:0006275 8 regulation of DNA replication 31 33 2 2 1 1 0 0 38 33 2476 0.607 1.0 1.0 0.0 0 0 0 0 0 GO:0006301 7 postreplication repair 6 6 1 1 1 0 0 0 38 6 2503 0.91367 1.0 1.0 0.0 0 0 0 0 0 GO:0006325 5 chromatin organization 88 101 3 3 2 1 0 0 38 101 2408 0.21244 1.0 0.40172 0.0 0 0 0 0 0 GO:0006333 6 chromatin assembly or disassembly 14 16 1 1 1 0 0 0 38 16 2493 0.78566 1.0 1.0 0.0 0 0 0 0 0 GO:0006334 7 nucleosome assembly 12 19 1 1 1 0 0 0 38 19 2490 0.75079 1.0 1.0 0.0 0 0 0 0 0 GO:0006335 8 DNA replication-dependent nucleosome assembly 3 4 1 1 1 0 0 0 38 4 2505 0.94161 1.0 1.0 0.0 0 0 0 0 0 GO:0006336 8 DNA replication-independent nucleosome assembly 4 4 1 1 1 0 0 0 38 4 2505 0.94161 1.0 1.0 0.0 0 0 0 0 0 GO:0006401 6 RNA catabolic process 23 25 1 1 1 0 0 0 38 25 2484 0.68551 1.0 1.0 0.0 0 0 0 0 0 GO:0006402 7 mRNA catabolic process 19 21 1 1 1 0 0 0 38 21 2488 0.72838 1.0 1.0 0.0 0 0 0 0 0 GO:0006417 7 regulation of translation 60 67 2 2 2 0 0 0 38 67 2442 0.36041 1.0 0.6244 0.0 0 0 0 0 0 GO:0006446 8 regulation of translational initiation 12 17 1 1 1 0 0 0 38 17 2492 0.77387 1.0 1.0 0.0 0 0 0 0 0 GO:0006468 7 protein phosphorylation 190 202 7 7 4 2 0 0 38 202 2307 0.042257 1.0 0.069304 0.0 0 0 0 0 0 GO:0006470 7 protein dephosphorylation 27 33 1 1 0 0 0 0 38 33 2476 0.607 1.0 1.0 0.0 0 0 0 0 0 GO:0006486 6 protein glycosylation 32 33 1 1 0 1 0 0 38 33 2476 0.607 1.0 1.0 0.0 0 0 0 0 0 GO:0006497 7 protein lipidation 9 9 1 1 0 1 0 0 38 9 2500 0.87328 1.0 1.0 0.0 0 0 0 0 0 GO:0006505 7 GPI anchor metabolic process 5 5 1 1 0 1 0 0 38 5 2504 0.92754 1.0 1.0 0.0 0 0 0 0 0 GO:0006506 7 GPI anchor biosynthetic process 4 4 1 1 0 1 0 0 38 4 2505 0.94161 1.0 1.0 0.0 0 0 0 0 0 GO:0006513 10 protein monoubiquitination 10 10 1 1 0 0 0 0 38 10 2499 0.8602 1.0 1.0 0.0 0 0 0 0 0 GO:0006518 5 peptide metabolic process 59 74 2 2 1 1 0 0 38 74 2435 0.32344 1.0 0.62664 0.0 0 0 0 0 0 GO:0006575 4 cellular modified amino acid metabolic process 61 71 2 2 1 1 0 0 38 71 2438 0.33881 1.0 0.62521 0.0 0 0 0 0 0 GO:0006606 6 protein import into nucleus 22 23 1 1 1 0 0 0 38 23 2486 0.70663 1.0 1.0 0.0 0 0 0 0 0 GO:0006633 6 fatty acid biosynthetic process 33 37 1 1 0 1 0 0 38 37 2472 0.57111 1.0 1.0 0.0 0 0 0 0 0 GO:0006636 7 unsaturated fatty acid biosynthetic process 13 17 1 1 0 1 0 0 38 17 2492 0.77387 1.0 1.0 0.0 0 0 0 0 0 GO:0006643 5 membrane lipid metabolic process 25 29 1 1 0 1 0 0 38 29 2480 0.64509 1.0 1.0 0.0 0 0 0 0 0 GO:0006661 7 phosphatidylinositol biosynthetic process 11 12 1 1 0 1 0 0 38 12 2497 0.83462 1.0 1.0 0.0 0 0 0 0 0 GO:0006664 6 glycolipid metabolic process 12 13 1 1 0 1 0 0 38 13 2496 0.82211 1.0 1.0 0.0 0 0 0 0 0 GO:0006692 6 prostanoid metabolic process 9 14 1 1 0 1 0 0 38 14 2495 0.80978 1.0 1.0 0.0 0 0 0 0 0 GO:0006693 7 prostaglandin metabolic process 9 14 1 1 0 1 0 0 38 14 2495 0.80978 1.0 1.0 0.0 0 0 0 0 0 GO:0006696 6 ergosterol biosynthetic process 1 1 1 1 0 0 0 0 38 1 2508 0.98508 1.0 1.0 0.0 0 0 0 0 0 GO:0006749 5 glutathione metabolic process 22 29 2 2 1 1 0 0 38 29 2480 0.64509 1.0 1.0 0.0 0 0 0 0 0 GO:0006775 5 fat-soluble vitamin metabolic process 10 13 1 1 0 0 0 0 38 13 2496 0.82211 1.0 1.0 0.0 0 0 0 0 0 GO:0006886 5 intracellular protein transport 114 122 1 1 1 0 0 0 38 122 2387 0.15271 1.0 0.25839 0.0 0 0 0 0 0 GO:0006887 5 exocytosis 32 34 1 1 0 1 0 0 38 34 2475 0.59783 1.0 1.0 0.0 0 0 0 0 0 GO:0006913 6 nucleocytoplasmic transport 37 41 1 1 1 0 0 0 38 41 2468 0.53728 1.0 1.0 0.0 0 0 0 0 0 GO:0006915 5 apoptotic process 137 149 3 2 2 0 0 0 38 149 2360 0.099459 1.0 0.16706 0.0 0 0 0 0 0 GO:0006919 10 activation of cysteine-type endopeptidase activity involved in apoptotic process 32 34 1 1 1 0 0 0 38 34 2475 0.59783 1.0 1.0 0.0 0 0 0 0 0 GO:0006954 5 inflammatory response 129 140 2 2 1 0 0 0 38 140 2369 0.1148 1.0 0.26769 0.0 0 0 0 0 0 GO:0006977 8 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest 5 5 1 1 1 0 0 0 38 5 2504 0.92754 1.0 1.0 0.0 0 0 0 0 0 GO:0006978 8 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator 4 4 1 1 1 0 0 0 38 4 2505 0.94161 1.0 1.0 0.0 0 0 0 0 0 GO:0006998 6 nuclear envelope organization 6 8 1 1 0 1 0 0 38 8 2501 0.88655 1.0 1.0 0.0 0 0 0 0 0 GO:0007019 6 microtubule depolymerization 5 5 1 1 0 0 0 0 38 5 2504 0.92754 1.0 1.0 0.0 0 0 0 0 0 GO:0007026 8 negative regulation of microtubule depolymerization 9 10 1 1 0 1 0 0 38 10 2499 0.8602 1.0 1.0 0.0 0 0 0 0 0 GO:0007049 3 cell cycle 49 56 10 9 2 4 0 0 38 56 2453 0.42695 1.0 1.0 0.0 0 0 0 0 0 GO:0007062 5 sister chromatid cohesion 12 13 3 3 1 2 0 0 38 13 2496 0.82211 1.0 1.0 0.0 0 0 0 0 0 GO:0007064 6 mitotic sister chromatid cohesion 5 6 2 2 0 2 0 0 38 6 2503 0.91367 1.0 1.0 0.0 0 0 0 0 0 GO:0007076 8 mitotic chromosome condensation 7 8 1 1 1 0 0 0 38 8 2501 0.88655 1.0 1.0 0.0 0 0 0 0 0 GO:0007080 6 mitotic metaphase plate congression 13 14 2 2 2 0 0 0 38 14 2495 0.80978 1.0 1.0 0.0 0 0 0 0 0 GO:0007088 7 regulation of mitotic nuclear division 43 46 6 5 3 2 0 0 38 46 2463 0.49773 1.0 1.0 0.0 0 0 0 0 0 GO:0007094 9 mitotic spindle assembly checkpoint 9 9 2 2 1 1 0 0 38 9 2500 0.87328 1.0 1.0 0.0 0 0 0 0 0 GO:0007095 9 mitotic G2 DNA damage checkpoint 5 6 1 1 1 0 0 0 38 6 2503 0.91367 1.0 1.0 0.0 0 0 0 0 0 GO:0007098 4 centrosome cycle 8 9 2 2 1 1 0 0 38 9 2500 0.87328 1.0 1.0 0.0 0 0 0 0 0 GO:0007099 5 centriole replication 4 4 1 1 1 0 0 0 38 4 2505 0.94161 1.0 1.0 0.0 0 0 0 0 0 GO:0007127 7 meiosis I 8 8 1 1 0 1 0 0 38 8 2501 0.88655 1.0 1.0 0.0 0 0 0 0 0 GO:0007140 7 male meiotic nuclear division 4 4 1 1 0 0 0 0 38 4 2505 0.94161 1.0 1.0 0.0 0 0 0 0 0 GO:0007159 5 leukocyte cell-cell adhesion 25 26 1 1 1 0 0 0 38 26 2483 0.67518 1.0 1.0 0.0 0 0 0 0 0 GO:0007163 3 establishment or maintenance of cell polarity 25 27 1 1 0 0 0 0 38 27 2482 0.665 1.0 1.0 0.0 0 0 0 0 0 GO:0007167 6 enzyme linked receptor protein signaling pathway 141 148 2 1 1 0 0 0 38 148 2361 0.10106 1.0 0.1671 0.0 0 0 0 0 0 GO:0007169 7 transmembrane receptor protein tyrosine kinase signaling pathway 107 112 2 1 1 0 0 0 38 112 2397 0.17877 1.0 0.41113 0.0 0 0 0 0 0 GO:0007275 3 multicellular organism development 107 118 3 2 2 0 0 0 38 118 2391 0.16265 1.0 0.4193 0.0 0 0 0 0 0 GO:0007389 3 pattern specification process 49 53 1 1 0 0 0 0 38 53 2456 0.44709 1.0 1.0 0.0 0 0 0 0 0 GO:0007507 5 heart development 69 74 1 1 1 0 0 0 38 74 2435 0.32344 1.0 0.62664 0.0 0 0 0 0 0 GO:0007569 4 cell aging 31 33 1 1 1 0 0 0 38 33 2476 0.607 1.0 1.0 0.0 0 0 0 0 0 GO:0008204 5 ergosterol metabolic process 1 1 1 1 0 0 0 0 38 1 2508 0.98508 1.0 1.0 0.0 0 0 0 0 0 GO:0008209 6 androgen metabolic process 15 15 1 1 0 1 0 0 38 15 2494 0.79763 1.0 1.0 0.0 0 0 0 0 0 GO:0008219 3 cell death 158 170 4 3 2 0 0 0 38 170 2339 0.071015 1.0 0.17617 0.0 0 0 0 0 0 GO:0008300 6 isoprenoid catabolic process 3 3 1 1 0 0 0 0 38 3 2506 0.95589 1.0 1.0 0.0 0 0 0 0 0 GO:0008543 8 fibroblast growth factor receptor signaling pathway 12 13 1 1 1 0 0 0 38 13 2496 0.82211 1.0 1.0 0.0 0 0 0 0 0 GO:0008630 7 intrinsic apoptotic signaling pathway in response to DNA damage 37 38 2 1 1 0 0 0 38 38 2471 0.56246 1.0 1.0 0.0 0 0 0 0 0 GO:0009111 5 vitamin catabolic process 5 6 1 1 0 0 0 0 38 6 2503 0.91367 1.0 1.0 0.0 0 0 0 0 0 GO:0009247 6 glycolipid biosynthetic process 6 7 1 1 0 1 0 0 38 7 2502 0.90001 1.0 1.0 0.0 0 0 0 0 0 GO:0009411 6 response to UV 49 51 3 3 2 0 0 0 38 51 2458 0.46102 1.0 1.0 0.0 0 0 0 0 0 GO:0009755 5 hormone-mediated signaling pathway 41 44 2 2 1 1 0 0 38 44 2465 0.5132 1.0 1.0 0.0 0 0 0 0 0 GO:0009790 4 embryo development 68 71 1 1 1 0 0 0 38 71 2438 0.33881 1.0 0.62521 0.0 0 0 0 0 0 GO:0009792 5 embryo development ending in birth or egg hatching 67 70 1 1 1 0 0 0 38 70 2439 0.34409 1.0 0.62489 0.0 0 0 0 0 0 GO:0009887 4 animal organ morphogenesis 110 116 1 1 0 0 0 0 38 116 2393 0.16786 1.0 0.41637 0.0 0 0 0 0 0 GO:0009954 5 proximal/distal pattern formation 4 5 1 1 0 0 0 0 38 5 2504 0.92754 1.0 1.0 0.0 0 0 0 0 0 GO:0010165 6 response to X-ray 13 13 1 1 1 0 0 0 38 13 2496 0.82211 1.0 1.0 0.0 0 0 0 0 0 GO:0010224 7 response to UV-B 7 8 1 1 1 0 0 0 38 8 2501 0.88655 1.0 1.0 0.0 0 0 0 0 0 GO:0010389 8 regulation of G2/M transition of mitotic cell cycle 26 27 5 4 3 0 0 0 38 27 2482 0.665 1.0 1.0 0.0 0 0 0 0 0 GO:0010457 4 centriole-centriole cohesion 1 1 1 1 0 1 0 0 38 1 2508 0.98508 1.0 1.0 0.0 0 0 0 0 0 GO:0010498 6 proteasomal protein catabolic process 41 43 2 1 0 1 0 0 38 43 2466 0.52111 1.0 1.0 0.0 0 0 0 0 0 GO:0010608 7 posttranscriptional regulation of gene expression 70 78 2 2 2 0 0 0 38 78 2431 0.304 1.0 0.6295 0.0 0 0 0 0 0 GO:0010631 6 epithelial cell migration 28 30 1 1 1 0 0 0 38 30 2479 0.63536 1.0 1.0 0.0 0 0 0 0 0 GO:0010638 7 positive regulation of organelle organization 145 155 3 3 3 0 0 0 38 155 2354 0.09036 1.0 0.16777 0.0 0 0 0 0 0 GO:0010677 7 negative regulation of cellular carbohydrate metabolic process 17 20 1 0 0 0 0 0 38 20 2489 0.73951 1.0 1.0 0.0 0 0 0 0 0 GO:0010721 7 negative regulation of cell development 88 93 1 1 1 0 0 0 38 93 2416 0.24074 1.0 0.40024 0.0 0 0 0 0 0 GO:0010749 7 regulation of nitric oxide mediated signal transduction 4 4 1 0 0 1 0 0 38 4 2505 0.94161 1.0 1.0 0.0 0 0 0 0 0 GO:0010751 8 negative regulation of nitric oxide mediated signal transduction 1 1 1 0 0 1 0 0 38 1 2508 0.98508 1.0 1.0 0.0 0 0 0 0 0 GO:0010799 9 regulation of peptidyl-threonine phosphorylation 13 15 2 1 0 1 0 0 38 15 2494 0.79763 1.0 1.0 0.0 0 0 0 0 0 GO:0010800 10 positive regulation of peptidyl-threonine phosphorylation 10 11 1 1 0 1 0 0 38 11 2498 0.84732 1.0 1.0 0.0 0 0 0 0 0 GO:0010801 10 negative regulation of peptidyl-threonine phosphorylation 4 5 1 0 0 0 0 0 38 5 2504 0.92754 1.0 1.0 0.0 0 0 0 0 0 GO:0010824 8 regulation of centrosome duplication 6 7 2 1 1 0 0 0 38 7 2502 0.90001 1.0 1.0 0.0 0 0 0 0 0 GO:0010825 9 positive regulation of centrosome duplication 2 3 1 1 1 0 0 0 38 3 2506 0.95589 1.0 1.0 0.0 0 0 0 0 0 GO:0010826 9 negative regulation of centrosome duplication 2 3 1 0 0 0 0 0 38 3 2506 0.95589 1.0 1.0 0.0 0 0 0 0 0 GO:0010830 8 regulation of myotube differentiation 21 22 1 1 0 0 0 0 38 22 2487 0.71743 1.0 1.0 0.0 0 0 0 0 0 GO:0010831 9 positive regulation of myotube differentiation 11 12 1 1 0 0 0 0 38 12 2497 0.83462 1.0 1.0 0.0 0 0 0 0 0 GO:0010837 7 regulation of keratinocyte proliferation 7 8 1 1 1 0 0 0 38 8 2501 0.88655 1.0 1.0 0.0 0 0 0 0 0 GO:0010950 8 positive regulation of endopeptidase activity 54 58 1 1 1 0 0 0 38 58 2451 0.41402 1.0 1.0 0.0 0 0 0 0 0 GO:0010952 7 positive regulation of peptidase activity 63 67 1 1 1 0 0 0 38 67 2442 0.36041 1.0 0.6244 0.0 0 0 0 0 0 GO:0010965 7 regulation of mitotic sister chromatid separation 16 16 4 3 2 1 0 0 38 16 2493 0.78566 1.0 1.0 0.0 0 0 0 0 0 GO:0010971 9 positive regulation of G2/M transition of mitotic cell cycle 10 10 1 1 1 0 0 0 38 10 2499 0.8602 1.0 1.0 0.0 0 0 0 0 0 GO:0010972 9 negative regulation of G2/M transition of mitotic cell cycle 12 13 3 2 2 0 0 0 38 13 2496 0.82211 1.0 1.0 0.0 0 0 0 0 0 GO:0010999 6 regulation of eIF2 alpha phosphorylation by heme 1 1 1 1 1 0 0 0 38 1 2508 0.98508 1.0 1.0 0.0 0 0 0 0 0 GO:0012501 4 programmed cell death 149 161 4 3 2 0 0 0 38 161 2348 0.082074 1.0 0.17003 0.0 0 0 0 0 0 GO:0014002 6 astrocyte development 4 4 1 1 1 0 0 0 38 4 2505 0.94161 1.0 1.0 0.0 0 0 0 0 0 GO:0014003 6 oligodendrocyte development 7 7 1 1 0 1 0 0 38 7 2502 0.90001 1.0 1.0 0.0 0 0 0 0 0 GO:0014059 5 regulation of dopamine secretion 10 10 1 1 0 1 0 0 38 10 2499 0.8602 1.0 1.0 0.0 0 0 0 0 0 GO:0014910 7 regulation of smooth muscle cell migration 45 50 1 1 0 1 0 0 38 50 2459 0.46814 1.0 1.0 0.0 0 0 0 0 0 GO:0014912 8 negative regulation of smooth muscle cell migration 13 14 1 1 0 1 0 0 38 14 2495 0.80978 1.0 1.0 0.0 0 0 0 0 0 GO:0015669 5 gas transport 4 7 1 1 1 0 0 0 38 7 2502 0.90001 1.0 1.0 0.0 0 0 0 0 0 GO:0015671 6 oxygen transport 4 7 1 1 1 0 0 0 38 7 2502 0.90001 1.0 1.0 0.0 0 0 0 0 0 GO:0015893 5 drug transport 30 33 1 1 1 0 0 0 38 33 2476 0.607 1.0 1.0 0.0 0 0 0 0 0 GO:0015931 6 nucleobase-containing compound transport 29 31 1 1 1 0 0 0 38 31 2478 0.62577 1.0 1.0 0.0 0 0 0 0 0 GO:0016042 5 lipid catabolic process 77 87 1 1 0 0 0 0 38 87 2422 0.26433 1.0 0.63934 0.0 0 0 0 0 0 GO:0016071 7 mRNA metabolic process 53 60 1 1 1 0 0 0 38 60 2449 0.40148 1.0 1.0 0.0 0 0 0 0 0 GO:0016079 5 synaptic vesicle exocytosis 8 8 1 1 0 1 0 0 38 8 2501 0.88655 1.0 1.0 0.0 0 0 0 0 0 GO:0016103 8 diterpenoid catabolic process 2 2 1 1 0 0 0 0 38 2 2507 0.97038 1.0 1.0 0.0 0 0 0 0 0 GO:0016115 7 terpenoid catabolic process 2 2 1 1 0 0 0 0 38 2 2507 0.97038 1.0 1.0 0.0 0 0 0 0 0 GO:0016128 5 phytosteroid metabolic process 2 2 1 1 0 0 0 0 38 2 2507 0.97038 1.0 1.0 0.0 0 0 0 0 0 GO:0016129 6 phytosteroid biosynthetic process 2 2 1 1 0 0 0 0 38 2 2507 0.97038 1.0 1.0 0.0 0 0 0 0 0 GO:0016202 6 regulation of striated muscle tissue development 55 57 4 4 1 1 0 0 38 57 2452 0.42044 1.0 1.0 0.0 0 0 0 0 0 GO:0016311 6 dephosphorylation 44 50 1 1 0 0 0 0 38 50 2459 0.46814 1.0 1.0 0.0 0 0 0 0 0 GO:0016321 4 female meiosis chromosome segregation 2 2 2 2 1 1 0 0 38 2 2507 0.97038 1.0 1.0 0.0 0 0 0 0 0 GO:0016569 6 covalent chromatin modification 49 53 2 2 1 1 0 0 38 53 2456 0.44709 1.0 1.0 0.0 0 0 0 0 0 GO:0016570 7 histone modification 48 51 2 2 1 1 0 0 38 51 2458 0.46102 1.0 1.0 0.0 0 0 0 0 0 GO:0016572 8 histone phosphorylation 12 12 2 2 1 1 0 0 38 12 2497 0.83462 1.0 1.0 0.0 0 0 0 0 0 GO:0016579 8 protein deubiquitination 9 9 1 0 1 0 0 0 38 9 2500 0.87328 1.0 1.0 0.0 0 0 0 0 0 GO:0017001 5 antibiotic catabolic process 20 22 1 1 1 0 0 0 38 22 2487 0.71743 1.0 1.0 0.0 0 0 0 0 0 GO:0017014 7 protein nitrosylation 4 7 1 1 1 0 0 0 38 7 2502 0.90001 1.0 1.0 0.0 0 0 0 0 0 GO:0017038 6 protein import 28 30 1 1 1 0 0 0 38 30 2479 0.63536 1.0 1.0 0.0 0 0 0 0 0 GO:0017148 8 negative regulation of translation 21 22 1 1 1 0 0 0 38 22 2487 0.71743 1.0 1.0 0.0 0 0 0 0 0 GO:0017156 7 calcium-ion regulated exocytosis 6 7 1 1 0 1 0 0 38 7 2502 0.90001 1.0 1.0 0.0 0 0 0 0 0 GO:0017157 6 regulation of exocytosis 48 54 1 1 0 1 0 0 38 54 2455 0.44028 1.0 1.0 0.0 0 0 0 0 0 GO:0017158 8 regulation of calcium ion-dependent exocytosis 6 6 1 1 0 1 0 0 38 6 2503 0.91367 1.0 1.0 0.0 0 0 0 0 0 GO:0018105 8 peptidyl-serine phosphorylation 56 56 3 3 2 1 0 0 38 56 2453 0.42695 1.0 1.0 0.0 0 0 0 0 0 GO:0018107 8 peptidyl-threonine phosphorylation 18 18 1 1 1 0 0 0 38 18 2491 0.76224 1.0 1.0 0.0 0 0 0 0 0 GO:0018108 8 peptidyl-tyrosine phosphorylation 45 50 1 1 1 0 0 0 38 50 2459 0.46814 1.0 1.0 0.0 0 0 0 0 0 GO:0018119 8 peptidyl-cysteine S-nitrosylation 4 7 1 1 1 0 0 0 38 7 2502 0.90001 1.0 1.0 0.0 0 0 0 0 0 GO:0018193 7 peptidyl-amino acid modification 169 184 4 4 3 1 0 0 38 184 2325 0.056636 1.0 0.10867 0.0 0 0 0 0 0 GO:0018198 8 peptidyl-cysteine modification 7 10 1 1 1 0 0 0 38 10 2499 0.8602 1.0 1.0 0.0 0 0 0 0 0 GO:0018209 8 peptidyl-serine modification 61 61 3 3 2 1 0 0 38 61 2448 0.39534 1.0 1.0 0.0 0 0 0 0 0 GO:0018210 8 peptidyl-threonine modification 19 19 1 1 1 0 0 0 38 19 2490 0.75079 1.0 1.0 0.0 0 0 0 0 0 GO:0018212 8 peptidyl-tyrosine modification 45 50 1 1 1 0 0 0 38 50 2459 0.46814 1.0 1.0 0.0 0 0 0 0 0 GO:0019585 8 glucuronate metabolic process 3 10 1 1 0 1 0 0 38 10 2499 0.8602 1.0 1.0 0.0 0 0 0 0 0 GO:0019985 8 translesion synthesis 4 4 1 1 1 0 0 0 38 4 2505 0.94161 1.0 1.0 0.0 0 0 0 0 0 GO:0021591 5 ventricular system development 6 7 1 1 0 0 0 0 38 7 2502 0.90001 1.0 1.0 0.0 0 0 0 0 0 GO:0021700 3 developmental maturation 49 51 3 2 2 1 0 0 38 51 2458 0.46102 1.0 1.0 0.0 0 0 0 0 0 GO:0021782 5 glial cell development 22 22 3 3 2 1 0 0 38 22 2487 0.71743 1.0 1.0 0.0 0 0 0 0 0 GO:0022411 5 cellular component disassembly 46 49 3 2 0 1 0 0 38 49 2460 0.47538 1.0 1.0 0.0 0 0 0 0 0 GO:0023014 7 signal transduction by protein phosphorylation 49 51 1 1 1 0 0 0 38 51 2458 0.46102 1.0 1.0 0.0 0 0 0 0 0 GO:0023061 6 signal release 45 48 1 1 0 1 0 0 38 48 2461 0.48272 1.0 1.0 0.0 0 0 0 0 0 GO:0030010 4 establishment of cell polarity 13 15 1 1 0 0 0 0 38 15 2494 0.79763 1.0 1.0 0.0 0 0 0 0 0 GO:0030031 6 cell projection assembly 41 43 1 1 0 0 0 0 38 43 2466 0.52111 1.0 1.0 0.0 0 0 0 0 0 GO:0030071 8 regulation of mitotic metaphase/anaphase transition 15 15 4 3 2 1 0 0 38 15 2494 0.79763 1.0 1.0 0.0 0 0 0 0 0 GO:0030097 6 hemopoiesis 28 29 1 1 1 0 0 0 38 29 2480 0.64509 1.0 1.0 0.0 0 0 0 0 0 GO:0030104 6 water homeostasis 14 14 1 1 0 0 0 0 38 14 2495 0.80978 1.0 1.0 0.0 0 0 0 0 0 GO:0030163 5 protein catabolic process 61 67 2 1 0 1 0 0 38 67 2442 0.36041 1.0 0.6244 0.0 0 0 0 0 0 GO:0030174 7 regulation of DNA-dependent DNA replication initiation 3 3 1 1 1 0 0 0 38 3 2506 0.95589 1.0 1.0 0.0 0 0 0 0 0 GO:0030203 6 glycosaminoglycan metabolic process 21 21 1 1 0 1 0 0 38 21 2488 0.72838 1.0 1.0 0.0 0 0 0 0 0 GO:0030212 7 hyaluronan metabolic process 14 14 1 1 0 1 0 0 38 14 2495 0.80978 1.0 1.0 0.0 0 0 0 0 0 GO:0030224 7 monocyte differentiation 8 8 1 1 1 0 0 0 38 8 2501 0.88655 1.0 1.0 0.0 0 0 0 0 0 GO:0030308 6 negative regulation of cell growth 49 53 1 1 1 0 0 0 38 53 2456 0.44709 1.0 1.0 0.0 0 0 0 0 0 GO:0030326 6 embryonic limb morphogenesis 14 15 1 1 0 0 0 0 38 15 2494 0.79763 1.0 1.0 0.0 0 0 0 0 0 GO:0030330 7 DNA damage response, signal transduction by p53 class mediator 13 14 1 1 1 0 0 0 38 14 2495 0.80978 1.0 1.0 0.0 0 0 0 0 0 GO:0030336 7 negative regulation of cell migration 73 78 1 1 0 1 0 0 38 78 2431 0.304 1.0 0.6295 0.0 0 0 0 0 0 GO:0030397 6 membrane disassembly 3 3 1 1 0 1 0 0 38 3 2506 0.95589 1.0 1.0 0.0 0 0 0 0 0 GO:0030522 5 intracellular receptor signaling pathway 38 42 3 3 1 1 0 0 38 42 2467 0.52913 1.0 1.0 0.0 0 0 0 0 0 GO:0030593 8 neutrophil chemotaxis 31 32 1 1 1 0 0 0 38 32 2477 0.61632 1.0 1.0 0.0 0 0 0 0 0 GO:0030595 6 leukocyte chemotaxis 46 48 2 2 2 0 0 0 38 48 2461 0.48272 1.0 1.0 0.0 0 0 0 0 0 GO:0031023 4 microtubule organizing center organization 13 14 3 3 2 1 0 0 38 14 2495 0.80978 1.0 1.0 0.0 0 0 0 0 0 GO:0031056 8 regulation of histone modification 33 33 1 1 1 0 0 0 38 33 2476 0.607 1.0 1.0 0.0 0 0 0 0 0 GO:0031058 9 positive regulation of histone modification 24 24 1 1 1 0 0 0 38 24 2485 0.69599 1.0 1.0 0.0 0 0 0 0 0 GO:0031086 9 nuclear-transcribed mRNA catabolic process, deadenylation-independent decay 1 1 1 1 1 0 0 0 38 1 2508 0.98508 1.0 1.0 0.0 0 0 0 0 0 GO:0031098 6 stress-activated protein kinase signaling cascade 26 27 1 1 1 0 0 0 38 27 2482 0.665 1.0 1.0 0.0 0 0 0 0 0 GO:0031109 6 microtubule polymerization or depolymerization 11 11 1 1 0 0 0 0 38 11 2498 0.84732 1.0 1.0 0.0 0 0 0 0 0 GO:0031110 7 regulation of microtubule polymerization or depolymerization 24 26 2 2 0 2 0 0 38 26 2483 0.67518 1.0 1.0 0.0 0 0 0 0 0 GO:0031111 8 negative regulation of microtubule polymerization or depolymerization 12 13 1 1 0 1 0 0 38 13 2496 0.82211 1.0 1.0 0.0 0 0 0 0 0 GO:0031114 7 regulation of microtubule depolymerization 9 10 1 1 0 1 0 0 38 10 2499 0.8602 1.0 1.0 0.0 0 0 0 0 0 GO:0031145 9 anaphase-promoting complex-dependent catabolic process 2 2 1 1 0 1 0 0 38 2 2507 0.97038 1.0 1.0 0.0 0 0 0 0 0 GO:0031146 9 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process 5 5 1 0 0 0 0 0 38 5 2504 0.92754 1.0 1.0 0.0 0 0 0 0 0 GO:0031440 8 regulation of mRNA 3'-end processing 2 3 1 1 1 0 0 0 38 3 2506 0.95589 1.0 1.0 0.0 0 0 0 0 0 GO:0031442 9 positive regulation of mRNA 3'-end processing 2 3 1 1 1 0 0 0 38 3 2506 0.95589 1.0 1.0 0.0 0 0 0 0 0 GO:0031572 9 G2 DNA damage checkpoint 5 6 1 1 1 0 0 0 38 6 2503 0.91367 1.0 1.0 0.0 0 0 0 0 0 GO:0031577 7 spindle checkpoint 9 9 2 2 1 1 0 0 38 9 2500 0.87328 1.0 1.0 0.0 0 0 0 0 0 GO:0031648 5 protein destabilization 8 11 1 1 0 1 0 0 38 11 2498 0.84732 1.0 1.0 0.0 0 0 0 0 0 GO:0031915 6 positive regulation of synaptic plasticity 6 6 1 1 0 1 0 0 38 6 2503 0.91367 1.0 1.0 0.0 0 0 0 0 0 GO:0032006 7 regulation of TOR signaling 19 20 1 0 0 0 0 0 38 20 2489 0.73951 1.0 1.0 0.0 0 0 0 0 0 GO:0032007 8 negative regulation of TOR signaling 11 11 1 0 0 0 0 0 38 11 2498 0.84732 1.0 1.0 0.0 0 0 0 0 0 GO:0032091 6 negative regulation of protein binding 41 42 1 1 1 0 0 0 38 42 2467 0.52913 1.0 1.0 0.0 0 0 0 0 0 GO:0032435 11 negative regulation of proteasomal ubiquitin-dependent protein catabolic process 5 5 1 1 0 0 0 0 38 5 2504 0.92754 1.0 1.0 0.0 0 0 0 0 0 GO:0032526 5 response to retinoic acid 42 45 1 1 0 0 0 0 38 45 2464 0.50541 1.0 1.0 0.0 0 0 0 0 0 GO:0032651 7 regulation of interleukin-1 beta production 32 33 1 1 0 1 0 0 38 33 2476 0.607 1.0 1.0 0.0 0 0 0 0 0 GO:0032652 6 regulation of interleukin-1 production 37 38 1 1 0 1 0 0 38 38 2471 0.56246 1.0 1.0 0.0 0 0 0 0 0 GO:0032663 6 regulation of interleukin-2 production 17 18 1 1 1 0 0 0 38 18 2491 0.76224 1.0 1.0 0.0 0 0 0 0 0 GO:0032682 7 negative regulation of chemokine production 7 7 1 1 0 1 0 0 38 7 2502 0.90001 1.0 1.0 0.0 0 0 0 0 0 GO:0032691 8 negative regulation of interleukin-1 beta production 6 6 1 1 0 1 0 0 38 6 2503 0.91367 1.0 1.0 0.0 0 0 0 0 0 GO:0032692 7 negative regulation of interleukin-1 production 9 9 1 1 0 1 0 0 38 9 2500 0.87328 1.0 1.0 0.0 0 0 0 0 0 GO:0032703 7 negative regulation of interleukin-2 production 7 7 1 1 1 0 0 0 38 7 2502 0.90001 1.0 1.0 0.0 0 0 0 0 0 GO:0032720 8 negative regulation of tumor necrosis factor production 19 19 1 1 0 1 0 0 38 19 2490 0.75079 1.0 1.0 0.0 0 0 0 0 0 GO:0032872 7 regulation of stress-activated MAPK cascade 56 60 2 2 0 1 0 0 38 60 2449 0.40148 1.0 1.0 0.0 0 0 0 0 0 GO:0032873 8 negative regulation of stress-activated MAPK cascade 7 7 2 2 0 1 0 0 38 7 2502 0.90001 1.0 1.0 0.0 0 0 0 0 0 GO:0032897 6 negative regulation of viral transcription 7 7 1 1 1 0 0 0 38 7 2502 0.90001 1.0 1.0 0.0 0 0 0 0 0 GO:0032928 8 regulation of superoxide anion generation 19 19 1 1 0 1 0 0 38 19 2490 0.75079 1.0 1.0 0.0 0 0 0 0 0 GO:0032930 8 positive regulation of superoxide anion generation 17 17 1 1 0 1 0 0 38 17 2492 0.77387 1.0 1.0 0.0 0 0 0 0 0 GO:0032940 5 secretion by cell 76 81 1 1 0 1 0 0 38 81 2428 0.29017 1.0 0.63229 0.0 0 0 0 0 0 GO:0032984 6 protein-containing complex disassembly 18 21 2 1 0 0 0 0 38 21 2488 0.72838 1.0 1.0 0.0 0 0 0 0 0 GO:0033045 6 regulation of sister chromatid segregation 20 21 4 3 2 1 0 0 38 21 2488 0.72838 1.0 1.0 0.0 0 0 0 0 0 GO:0033046 7 negative regulation of sister chromatid segregation 12 12 2 2 1 1 0 0 38 12 2497 0.83462 1.0 1.0 0.0 0 0 0 0 0 GO:0033047 7 regulation of mitotic sister chromatid segregation 18 18 4 3 2 1 0 0 38 18 2491 0.76224 1.0 1.0 0.0 0 0 0 0 0 GO:0033048 8 negative regulation of mitotic sister chromatid segregation 12 12 2 2 1 1 0 0 38 12 2497 0.83462 1.0 1.0 0.0 0 0 0 0 0 GO:0033127 9 regulation of histone phosphorylation 5 5 1 1 1 0 0 0 38 5 2504 0.92754 1.0 1.0 0.0 0 0 0 0 0 GO:0033129 10 positive regulation of histone phosphorylation 3 3 1 1 1 0 0 0 38 3 2506 0.95589 1.0 1.0 0.0 0 0 0 0 0 GO:0033135 9 regulation of peptidyl-serine phosphorylation 38 46 1 0 0 0 0 0 38 46 2463 0.49773 1.0 1.0 0.0 0 0 0 0 0 GO:0033137 10 negative regulation of peptidyl-serine phosphorylation 12 12 1 0 0 0 0 0 38 12 2497 0.83462 1.0 1.0 0.0 0 0 0 0 0 GO:0033313 7 meiotic cell cycle checkpoint 1 1 1 1 1 0 0 0 38 1 2508 0.98508 1.0 1.0 0.0 0 0 0 0 0 GO:0033314 9 mitotic DNA replication checkpoint 3 4 2 1 1 0 0 0 38 4 2505 0.94161 1.0 1.0 0.0 0 0 0 0 0 GO:0033316 9 meiotic spindle assembly checkpoint 1 1 1 1 1 0 0 0 38 1 2508 0.98508 1.0 1.0 0.0 0 0 0 0 0 GO:0033365 6 protein localization to organelle 115 123 3 3 2 1 0 0 38 123 2386 0.15031 1.0 0.25842 0.0 0 0 0 0 0 GO:0033561 5 regulation of water loss via skin 8 8 1 1 0 0 0 0 38 8 2501 0.88655 1.0 1.0 0.0 0 0 0 0 0 GO:0033591 6 response to L-ascorbic acid 11 12 1 1 0 1 0 0 38 12 2497 0.83462 1.0 1.0 0.0 0 0 0 0 0 GO:0034198 6 cellular response to amino acid starvation 13 15 1 1 1 0 0 0 38 15 2494 0.79763 1.0 1.0 0.0 0 0 0 0 0 GO:0034248 6 regulation of cellular amide metabolic process 83 90 2 2 2 0 0 0 38 90 2419 0.25227 1.0 0.64349 0.0 0 0 0 0 0 GO:0034249 7 negative regulation of cellular amide metabolic process 28 29 1 1 1 0 0 0 38 29 2480 0.64509 1.0 1.0 0.0 0 0 0 0 0 GO:0034501 9 protein localization to kinetochore 5 7 1 1 1 0 0 0 38 7 2502 0.90001 1.0 1.0 0.0 0 0 0 0 0 GO:0034502 7 protein localization to chromosome 20 22 2 2 1 1 0 0 38 22 2487 0.71743 1.0 1.0 0.0 0 0 0 0 0 GO:0034504 7 protein localization to nucleus 39 40 2 2 1 1 0 0 38 40 2469 0.54555 1.0 1.0 0.0 0 0 0 0 0 GO:0034605 5 cellular response to heat 21 23 2 2 1 1 0 0 38 23 2486 0.70663 1.0 1.0 0.0 0 0 0 0 0 GO:0034612 6 response to tumor necrosis factor 76 79 1 1 1 0 0 0 38 79 2430 0.29932 1.0 0.63037 0.0 0 0 0 0 0 GO:0034613 5 cellular protein localization 184 195 3 3 2 1 0 0 38 195 2314 0.047367 1.0 0.11304 0.0 0 0 0 0 0 GO:0034644 7 cellular response to UV 32 34 2 2 1 0 0 0 38 34 2475 0.59783 1.0 1.0 0.0 0 0 0 0 0 GO:0034653 8 retinoic acid catabolic process 2 2 1 1 0 0 0 0 38 2 2507 0.97038 1.0 1.0 0.0 0 0 0 0 0 GO:0034655 5 nucleobase-containing compound catabolic process 33 39 1 1 1 0 0 0 38 39 2470 0.55394 1.0 1.0 0.0 0 0 0 0 0 GO:0034699 6 response to luteinizing hormone 6 7 1 1 0 1 0 0 38 7 2502 0.90001 1.0 1.0 0.0 0 0 0 0 0 GO:0034723 7 DNA replication-dependent nucleosome organization 3 4 1 1 1 0 0 0 38 4 2505 0.94161 1.0 1.0 0.0 0 0 0 0 0 GO:0034724 7 DNA replication-independent nucleosome organization 4 4 1 1 1 0 0 0 38 4 2505 0.94161 1.0 1.0 0.0 0 0 0 0 0 GO:0034728 6 nucleosome organization 18 25 1 1 1 0 0 0 38 25 2484 0.68551 1.0 1.0 0.0 0 0 0 0 0 GO:0035107 4 appendage morphogenesis 16 17 1 1 0 0 0 0 38 17 2492 0.77387 1.0 1.0 0.0 0 0 0 0 0 GO:0035108 5 limb morphogenesis 16 17 1 1 0 0 0 0 38 17 2492 0.77387 1.0 1.0 0.0 0 0 0 0 0 GO:0035113 5 embryonic appendage morphogenesis 14 15 1 1 0 0 0 0 38 15 2494 0.79763 1.0 1.0 0.0 0 0 0 0 0 GO:0035188 4 hatching 6 6 1 1 1 0 0 0 38 6 2503 0.91367 1.0 1.0 0.0 0 0 0 0 0 GO:0035278 10 miRNA mediated inhibition of translation 2 2 1 1 1 0 0 0 38 2 2507 0.97038 1.0 1.0 0.0 0 0 0 0 0 GO:0035335 8 peptidyl-tyrosine dephosphorylation 16 20 1 1 0 0 0 0 38 20 2489 0.73951 1.0 1.0 0.0 0 0 0 0 0 GO:0035404 9 histone-serine phosphorylation 5 5 1 1 1 0 0 0 38 5 2504 0.92754 1.0 1.0 0.0 0 0 0 0 0 GO:0035425 4 autocrine signaling 4 4 1 1 1 0 0 0 38 4 2505 0.94161 1.0 1.0 0.0 0 0 0 0 0 GO:0035519 11 protein K29-linked ubiquitination 1 1 1 1 0 0 0 0 38 1 2508 0.98508 1.0 1.0 0.0 0 0 0 0 0 GO:0035726 4 common myeloid progenitor cell proliferation 3 3 1 1 0 1 0 0 38 3 2506 0.95589 1.0 1.0 0.0 0 0 0 0 0 GO:0035754 8 B cell chemotaxis 1 1 1 1 1 0 0 0 38 1 2508 0.98508 1.0 1.0 0.0 0 0 0 0 0 GO:0035767 6 endothelial cell chemotaxis 3 3 1 1 1 0 0 0 38 3 2506 0.95589 1.0 1.0 0.0 0 0 0 0 0 GO:0035914 5 skeletal muscle cell differentiation 14 15 1 1 1 0 0 0 38 15 2494 0.79763 1.0 1.0 0.0 0 0 0 0 0 GO:0035924 7 cellular response to vascular endothelial growth factor stimulus 17 17 1 1 1 0 0 0 38 17 2492 0.77387 1.0 1.0 0.0 0 0 0 0 0 GO:0036119 4 response to platelet-derived growth factor 12 13 1 1 0 1 0 0 38 13 2496 0.82211 1.0 1.0 0.0 0 0 0 0 0 GO:0036120 6 cellular response to platelet-derived growth factor stimulus 12 13 1 1 0 1 0 0 38 13 2496 0.82211 1.0 1.0 0.0 0 0 0 0 0 GO:0036294 6 cellular response to decreased oxygen levels 61 64 2 2 1 1 0 0 38 64 2445 0.37748 1.0 1.0 0.0 0 0 0 0 0 GO:0038066 10 p38MAPK cascade 3 3 1 1 1 0 0 0 38 3 2506 0.95589 1.0 1.0 0.0 0 0 0 0 0 GO:0038179 6 neurotrophin signaling pathway 9 10 1 0 0 0 0 0 38 10 2499 0.8602 1.0 1.0 0.0 0 0 0 0 0 GO:0040001 7 establishment of mitotic spindle localization 10 10 2 2 1 1 0 0 38 10 2499 0.8602 1.0 1.0 0.0 0 0 0 0 0 GO:0040020 6 regulation of meiotic nuclear division 5 5 2 2 1 1 0 0 38 5 2504 0.92754 1.0 1.0 0.0 0 0 0 0 0 GO:0040033 9 negative regulation of translation, ncRNA-mediated 2 2 1 1 1 0 0 0 38 2 2507 0.97038 1.0 1.0 0.0 0 0 0 0 0 GO:0042036 7 negative regulation of cytokine biosynthetic process 9 9 1 1 1 0 0 0 38 9 2500 0.87328 1.0 1.0 0.0 0 0 0 0 0 GO:0042060 5 wound healing 52 55 1 1 1 0 0 0 38 55 2454 0.43356 1.0 1.0 0.0 0 0 0 0 0 GO:0042177 7 negative regulation of protein catabolic process 37 38 1 1 0 0 0 0 38 38 2471 0.56246 1.0 1.0 0.0 0 0 0 0 0 GO:0042363 6 fat-soluble vitamin catabolic process 4 4 1 1 0 0 0 0 38 4 2505 0.94161 1.0 1.0 0.0 0 0 0 0 0 GO:0042744 6 hydrogen peroxide catabolic process 11 11 1 1 1 0 0 0 38 11 2498 0.84732 1.0 1.0 0.0 0 0 0 0 0 GO:0042759 7 long-chain fatty acid biosynthetic process 4 6 1 1 0 1 0 0 38 6 2503 0.91367 1.0 1.0 0.0 0 0 0 0 0 GO:0042770 6 signal transduction in response to DNA damage 22 24 2 2 1 1 0 0 38 24 2485 0.69599 1.0 1.0 0.0 0 0 0 0 0 GO:0042771 8 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 12 12 2 1 1 0 0 0 38 12 2497 0.83462 1.0 1.0 0.0 0 0 0 0 0 GO:0042772 7 DNA damage response, signal transduction resulting in transcription 4 4 1 1 1 0 0 0 38 4 2505 0.94161 1.0 1.0 0.0 0 0 0 0 0 GO:0043009 6 chordate embryonic development 65 67 1 1 1 0 0 0 38 67 2442 0.36041 1.0 0.6244 0.0 0 0 0 0 0 GO:0043124 8 negative regulation of I-kappaB kinase/NF-kappaB signaling 16 18 1 1 0 1 0 0 38 18 2491 0.76224 1.0 1.0 0.0 0 0 0 0 0 GO:0043154 9 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process 41 42 1 1 1 0 0 0 38 42 2467 0.52913 1.0 1.0 0.0 0 0 0 0 0 GO:0043161 8 proteasome-mediated ubiquitin-dependent protein catabolic process 39 40 2 1 0 1 0 0 38 40 2469 0.54555 1.0 1.0 0.0 0 0 0 0 0 GO:0043242 7 negative regulation of protein-containing complex disassembly 13 15 1 1 0 1 0 0 38 15 2494 0.79763 1.0 1.0 0.0 0 0 0 0 0 GO:0043244 6 regulation of protein-containing complex disassembly 19 21 1 1 0 1 0 0 38 21 2488 0.72838 1.0 1.0 0.0 0 0 0 0 0 GO:0043271 6 negative regulation of ion transport 40 43 1 0 0 1 0 0 38 43 2466 0.52111 1.0 1.0 0.0 0 0 0 0 0 GO:0043280 9 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process 44 47 1 1 1 0 0 0 38 47 2462 0.49017 1.0 1.0 0.0 0 0 0 0 0 GO:0043281 8 regulation of cysteine-type endopeptidase activity involved in apoptotic process 84 87 2 2 2 0 0 0 38 87 2422 0.26433 1.0 0.63934 0.0 0 0 0 0 0 GO:0043401 6 steroid hormone mediated signaling pathway 34 37 2 2 1 1 0 0 38 37 2472 0.57111 1.0 1.0 0.0 0 0 0 0 0 GO:0043405 8 regulation of MAP kinase activity 90 99 1 1 0 1 0 0 38 99 2410 0.2192 1.0 0.40089 0.0 0 0 0 0 0 GO:0043407 9 negative regulation of MAP kinase activity 22 24 1 1 0 1 0 0 38 24 2485 0.69599 1.0 1.0 0.0 0 0 0 0 0 GO:0043408 7 regulation of MAPK cascade 190 203 2 2 0 1 0 0 38 203 2306 0.041572 1.0 0.069278 0.0 0 0 0 0 0 GO:0043409 8 negative regulation of MAPK cascade 47 51 2 2 0 1 0 0 38 51 2458 0.46102 1.0 1.0 0.0 0 0 0 0 0 GO:0043413 4 macromolecule glycosylation 32 33 1 1 0 1 0 0 38 33 2476 0.607 1.0 1.0 0.0 0 0 0 0 0 GO:0043435 6 response to corticotropin-releasing hormone 2 2 1 1 1 0 0 0 38 2 2507 0.97038 1.0 1.0 0.0 0 0 0 0 0 GO:0043457 7 regulation of cellular respiration 16 17 1 1 1 0 0 0 38 17 2492 0.77387 1.0 1.0 0.0 0 0 0 0 0 GO:0043467 6 regulation of generation of precursor metabolites and energy 45 48 2 1 1 0 0 0 38 48 2461 0.48272 1.0 1.0 0.0 0 0 0 0 0 GO:0043470 6 regulation of carbohydrate catabolic process 24 25 1 0 0 0 0 0 38 25 2484 0.68551 1.0 1.0 0.0 0 0 0 0 0 GO:0043487 5 regulation of RNA stability 15 16 1 1 1 0 0 0 38 16 2493 0.78566 1.0 1.0 0.0 0 0 0 0 0 GO:0043488 6 regulation of mRNA stability 15 16 1 1 1 0 0 0 38 16 2493 0.78566 1.0 1.0 0.0 0 0 0 0 0 GO:0043489 6 RNA stabilization 10 10 1 1 1 0 0 0 38 10 2499 0.8602 1.0 1.0 0.0 0 0 0 0 0 GO:0043506 9 regulation of JUN kinase activity 18 21 1 1 0 1 0 0 38 21 2488 0.72838 1.0 1.0 0.0 0 0 0 0 0 GO:0043508 10 negative regulation of JUN kinase activity 1 1 1 1 0 1 0 0 38 1 2508 0.98508 1.0 1.0 0.0 0 0 0 0 0 GO:0043534 8 blood vessel endothelial cell migration 13 13 1 1 1 0 0 0 38 13 2496 0.82211 1.0 1.0 0.0 0 0 0 0 0 GO:0043542 7 endothelial cell migration 25 26 1 1 1 0 0 0 38 26 2483 0.67518 1.0 1.0 0.0 0 0 0 0 0 GO:0043587 6 tongue morphogenesis 2 2 1 1 0 0 0 0 38 2 2507 0.97038 1.0 1.0 0.0 0 0 0 0 0 GO:0043624 7 cellular protein complex disassembly 9 11 1 1 0 0 0 0 38 11 2498 0.84732 1.0 1.0 0.0 0 0 0 0 0 GO:0043900 4 regulation of multi-organism process 30 31 3 2 1 2 0 0 38 31 2478 0.62577 1.0 1.0 0.0 0 0 0 0 0 GO:0043901 5 negative regulation of multi-organism process 11 12 1 1 1 0 0 0 38 12 2497 0.83462 1.0 1.0 0.0 0 0 0 0 0 GO:0043902 5 positive regulation of multi-organism process 16 16 1 1 0 1 0 0 38 16 2493 0.78566 1.0 1.0 0.0 0 0 0 0 0 GO:0043987 10 histone H3-S10 phosphorylation 1 1 1 1 1 0 0 0 38 1 2508 0.98508 1.0 1.0 0.0 0 0 0 0 0 GO:0044058 6 regulation of digestive system process 11 12 1 0 0 1 0 0 38 12 2497 0.83462 1.0 1.0 0.0 0 0 0 0 0 GO:0044089 6 positive regulation of cellular component biogenesis 110 121 1 1 1 0 0 0 38 121 2388 0.15514 1.0 0.25843 0.0 0 0 0 0 0 GO:0044107 4 cellular alcohol metabolic process 1 1 1 1 0 0 0 0 38 1 2508 0.98508 1.0 1.0 0.0 0 0 0 0 0 GO:0044108 5 cellular alcohol biosynthetic process 1 1 1 1 0 0 0 0 38 1 2508 0.98508 1.0 1.0 0.0 0 0 0 0 0 GO:0044242 5 cellular lipid catabolic process 56 64 1 1 0 0 0 0 38 64 2445 0.37748 1.0 1.0 0.0 0 0 0 0 0 GO:0044270 5 cellular nitrogen compound catabolic process 51 59 1 1 1 0 0 0 38 59 2450 0.4077 1.0 1.0 0.0 0 0 0 0 0 GO:0044272 5 sulfur compound biosynthetic process 25 31 1 1 0 1 0 0 38 31 2478 0.62577 1.0 1.0 0.0 0 0 0 0 0 GO:0044314 11 protein K27-linked ubiquitination 1 1 1 1 0 0 0 0 38 1 2508 0.98508 1.0 1.0 0.0 0 0 0 0 0 GO:0044320 6 cellular response to leptin stimulus 5 5 1 1 0 1 0 0 38 5 2504 0.92754 1.0 1.0 0.0 0 0 0 0 0 GO:0044321 5 response to leptin 8 9 1 1 0 1 0 0 38 9 2500 0.87328 1.0 1.0 0.0 0 0 0 0 0 GO:0044344 6 cellular response to fibroblast growth factor stimulus 25 26 2 2 2 0 0 0 38 26 2483 0.67518 1.0 1.0 0.0 0 0 0 0 0 GO:0044380 7 protein localization to cytoskeleton 8 10 1 1 1 0 0 0 38 10 2499 0.8602 1.0 1.0 0.0 0 0 0 0 0 GO:0044770 4 cell cycle phase transition 48 50 6 5 2 3 0 0 38 50 2459 0.46814 1.0 1.0 0.0 0 0 0 0 0 GO:0044772 5 mitotic cell cycle phase transition 44 46 6 5 2 3 0 0 38 46 2463 0.49773 1.0 1.0 0.0 0 0 0 0 0 GO:0044773 9 mitotic DNA damage checkpoint 13 14 1 1 1 0 0 0 38 14 2495 0.80978 1.0 1.0 0.0 0 0 0 0 0 GO:0044779 8 meiotic spindle checkpoint 1 1 1 1 1 0 0 0 38 1 2508 0.98508 1.0 1.0 0.0 0 0 0 0 0 GO:0044782 6 cilium organization 18 19 1 1 0 0 0 0 38 19 2490 0.75079 1.0 1.0 0.0 0 0 0 0 0 GO:0044818 8 mitotic G2/M transition checkpoint 9 10 3 2 2 0 0 0 38 10 2499 0.8602 1.0 1.0 0.0 0 0 0 0 0 GO:0044839 5 cell cycle G2/M phase transition 18 18 3 3 1 2 0 0 38 18 2491 0.76224 1.0 1.0 0.0 0 0 0 0 0 GO:0044843 5 cell cycle G1/S phase transition 24 26 2 2 1 1 0 0 38 26 2483 0.67518 1.0 1.0 0.0 0 0 0 0 0 GO:0045017 5 glycerolipid biosynthetic process 25 29 1 1 0 1 0 0 38 29 2480 0.64509 1.0 1.0 0.0 0 0 0 0 0 GO:0045055 6 regulated exocytosis 21 22 1 1 0 1 0 0 38 22 2487 0.71743 1.0 1.0 0.0 0 0 0 0 0 GO:0045076 7 regulation of interleukin-2 biosynthetic process 7 7 1 1 1 0 0 0 38 7 2502 0.90001 1.0 1.0 0.0 0 0 0 0 0 GO:0045085 8 negative regulation of interleukin-2 biosynthetic process 2 2 1 1 1 0 0 0 38 2 2507 0.97038 1.0 1.0 0.0 0 0 0 0 0 GO:0045087 5 innate immune response 79 87 1 1 1 0 0 0 38 87 2422 0.26433 1.0 0.63934 0.0 0 0 0 0 0 GO:0045143 5 homologous chromosome segregation 4 4 2 2 0 2 0 0 38 4 2505 0.94161 1.0 1.0 0.0 0 0 0 0 0 GO:0045580 8 regulation of T cell differentiation 44 47 1 1 0 0 0 0 38 47 2462 0.49017 1.0 1.0 0.0 0 0 0 0 0 GO:0045596 6 negative regulation of cell differentiation 184 195 2 2 2 0 0 0 38 195 2314 0.047367 1.0 0.11304 0.0 0 0 0 0 0 GO:0045604 6 regulation of epidermal cell differentiation 11 11 1 1 1 0 0 0 38 11 2498 0.84732 1.0 1.0 0.0 0 0 0 0 0 GO:0045616 7 regulation of keratinocyte differentiation 5 5 1 1 1 0 0 0 38 5 2504 0.92754 1.0 1.0 0.0 0 0 0 0 0 GO:0045619 7 regulation of lymphocyte differentiation 50 53 1 1 0 0 0 0 38 53 2456 0.44709 1.0 1.0 0.0 0 0 0 0 0 GO:0045638 7 negative regulation of myeloid cell differentiation 29 31 1 1 1 0 0 0 38 31 2478 0.62577 1.0 1.0 0.0 0 0 0 0 0 GO:0045646 5 regulation of erythrocyte differentiation 19 21 1 1 1 0 0 0 38 21 2488 0.72838 1.0 1.0 0.0 0 0 0 0 0 GO:0045647 6 negative regulation of erythrocyte differentiation 2 3 1 1 1 0 0 0 38 3 2506 0.95589 1.0 1.0 0.0 0 0 0 0 0 GO:0045682 5 regulation of epidermis development 17 18 1 1 1 0 0 0 38 18 2491 0.76224 1.0 1.0 0.0 0 0 0 0 0 GO:0045736 9 negative regulation of cyclin-dependent protein serine/threonine kinase activity 8 8 2 2 1 1 0 0 38 8 2501 0.88655 1.0 1.0 0.0 0 0 0 0 0 GO:0045737 9 positive regulation of cyclin-dependent protein serine/threonine kinase activity 17 17 3 2 1 1 0 0 38 17 2492 0.77387 1.0 1.0 0.0 0 0 0 0 0 GO:0045820 7 negative regulation of glycolytic process 7 7 1 0 0 0 0 0 38 7 2502 0.90001 1.0 1.0 0.0 0 0 0 0 0 GO:0045835 7 negative regulation of meiotic nuclear division 1 1 1 1 1 0 0 0 38 1 2508 0.98508 1.0 1.0 0.0 0 0 0 0 0 GO:0045839 8 negative regulation of mitotic nuclear division 15 15 2 2 1 1 0 0 38 15 2494 0.79763 1.0 1.0 0.0 0 0 0 0 0 GO:0045840 8 positive regulation of mitotic nuclear division 21 24 1 1 1 0 0 0 38 24 2485 0.69599 1.0 1.0 0.0 0 0 0 0 0 GO:0045841 9 negative regulation of mitotic metaphase/anaphase transition 10 10 2 2 1 1 0 0 38 10 2499 0.8602 1.0 1.0 0.0 0 0 0 0 0 GO:0045844 7 positive regulation of striated muscle tissue development 30 32 2 2 1 0 0 0 38 32 2477 0.61632 1.0 1.0 0.0 0 0 0 0 0 GO:0045912 6 negative regulation of carbohydrate metabolic process 20 23 1 0 0 0 0 0 38 23 2486 0.70663 1.0 1.0 0.0 0 0 0 0 0 GO:0045974 8 regulation of translation, ncRNA-mediated 2 2 1 1 1 0 0 0 38 2 2507 0.97038 1.0 1.0 0.0 0 0 0 0 0 GO:0045980 7 negative regulation of nucleotide metabolic process 8 9 1 0 0 0 0 0 38 9 2500 0.87328 1.0 1.0 0.0 0 0 0 0 0 GO:0046328 8 regulation of JNK cascade 41 44 1 1 0 1 0 0 38 44 2465 0.5132 1.0 1.0 0.0 0 0 0 0 0 GO:0046329 9 negative regulation of JNK cascade 5 5 1 1 0 1 0 0 38 5 2504 0.92754 1.0 1.0 0.0 0 0 0 0 0 GO:0046467 5 membrane lipid biosynthetic process 13 16 1 1 0 1 0 0 38 16 2493 0.78566 1.0 1.0 0.0 0 0 0 0 0 GO:0046474 6 glycerophospholipid biosynthetic process 21 23 1 1 0 1 0 0 38 23 2486 0.70663 1.0 1.0 0.0 0 0 0 0 0 GO:0046599 7 regulation of centriole replication 4 5 1 1 1 0 0 0 38 5 2504 0.92754 1.0 1.0 0.0 0 0 0 0 0 GO:0046601 8 positive regulation of centriole replication 2 2 1 1 1 0 0 0 38 2 2507 0.97038 1.0 1.0 0.0 0 0 0 0 0 GO:0046605 7 regulation of centrosome cycle 10 11 2 1 1 0 0 0 38 11 2498 0.84732 1.0 1.0 0.0 0 0 0 0 0 GO:0046606 8 negative regulation of centrosome cycle 2 3 1 0 0 0 0 0 38 3 2506 0.95589 1.0 1.0 0.0 0 0 0 0 0 GO:0046607 8 positive regulation of centrosome cycle 2 3 1 1 1 0 0 0 38 3 2506 0.95589 1.0 1.0 0.0 0 0 0 0 0 GO:0046620 5 regulation of organ growth 36 37 1 1 1 0 0 0 38 37 2472 0.57111 1.0 1.0 0.0 0 0 0 0 0 GO:0046622 6 positive regulation of organ growth 17 18 1 1 1 0 0 0 38 18 2491 0.76224 1.0 1.0 0.0 0 0 0 0 0 GO:0046680 5 response to DDT 1 1 1 1 1 0 0 0 38 1 2508 0.98508 1.0 1.0 0.0 0 0 0 0 0 GO:0046777 8 protein autophosphorylation 52 55 1 1 1 0 0 0 38 55 2454 0.43356 1.0 1.0 0.0 0 0 0 0 0 GO:0046782 6 regulation of viral transcription 13 13 1 1 1 0 0 0 38 13 2496 0.82211 1.0 1.0 0.0 0 0 0 0 0 GO:0046883 5 regulation of hormone secretion 83 89 1 0 0 1 0 0 38 89 2420 0.25623 1.0 0.64206 0.0 0 0 0 0 0 GO:0046887 6 positive regulation of hormone secretion 46 50 1 0 0 1 0 0 38 50 2459 0.46814 1.0 1.0 0.0 0 0 0 0 0 GO:0048011 7 neurotrophin TRK receptor signaling pathway 6 7 1 0 0 0 0 0 38 7 2502 0.90001 1.0 1.0 0.0 0 0 0 0 0 GO:0048145 6 regulation of fibroblast proliferation 37 41 5 4 2 2 0 0 38 41 2468 0.53728 1.0 1.0 0.0 0 0 0 0 0 GO:0048146 7 positive regulation of fibroblast proliferation 27 30 4 3 2 1 0 0 38 30 2479 0.63536 1.0 1.0 0.0 0 0 0 0 0 GO:0048147 7 negative regulation of fibroblast proliferation 11 11 1 1 0 1 0 0 38 11 2498 0.84732 1.0 1.0 0.0 0 0 0 0 0 GO:0048167 5 regulation of synaptic plasticity 59 62 1 1 0 1 0 0 38 62 2447 0.3893 1.0 1.0 0.0 0 0 0 0 0 GO:0048240 4 sperm capacitation 5 5 1 0 0 1 0 0 38 5 2504 0.92754 1.0 1.0 0.0 0 0 0 0 0 GO:0048247 7 lymphocyte chemotaxis 19 19 1 1 1 0 0 0 38 19 2490 0.75079 1.0 1.0 0.0 0 0 0 0 0 GO:0048255 7 mRNA stabilization 10 10 1 1 1 0 0 0 38 10 2499 0.8602 1.0 1.0 0.0 0 0 0 0 0 GO:0048384 6 retinoic acid receptor signaling pathway 3 5 1 1 0 0 0 0 38 5 2504 0.92754 1.0 1.0 0.0 0 0 0 0 0 GO:0048385 6 regulation of retinoic acid receptor signaling pathway 5 5 1 1 0 0 0 0 38 5 2504 0.92754 1.0 1.0 0.0 0 0 0 0 0 GO:0048387 7 negative regulation of retinoic acid receptor signaling pathway 5 5 1 1 0 0 0 0 38 5 2504 0.92754 1.0 1.0 0.0 0 0 0 0 0 GO:0048469 4 cell maturation 37 38 3 2 2 1 0 0 38 38 2471 0.56246 1.0 1.0 0.0 0 0 0 0 0 GO:0048488 6 synaptic vesicle endocytosis 9 11 1 1 0 1 0 0 38 11 2498 0.84732 1.0 1.0 0.0 0 0 0 0 0 GO:0048525 5 negative regulation of viral process 30 32 1 1 1 0 0 0 38 32 2477 0.61632 1.0 1.0 0.0 0 0 0 0 0 GO:0048534 5 hematopoietic or lymphoid organ development 55 60 1 1 1 0 0 0 38 60 2449 0.40148 1.0 1.0 0.0 0 0 0 0 0 GO:0048634 6 regulation of muscle organ development 56 58 4 4 1 1 0 0 38 58 2451 0.41402 1.0 1.0 0.0 0 0 0 0 0 GO:0048636 6 positive regulation of muscle organ development 30 32 2 2 1 0 0 0 38 32 2477 0.61632 1.0 1.0 0.0 0 0 0 0 0 GO:0048640 6 negative regulation of developmental growth 30 32 1 1 1 0 0 0 38 32 2477 0.61632 1.0 1.0 0.0 0 0 0 0 0 GO:0048641 7 regulation of skeletal muscle tissue development 18 18 2 2 0 1 0 0 38 18 2491 0.76224 1.0 1.0 0.0 0 0 0 0 0 GO:0048643 8 positive regulation of skeletal muscle tissue development 10 10 1 1 0 0 0 0 38 10 2499 0.8602 1.0 1.0 0.0 0 0 0 0 0 GO:0048660 6 regulation of smooth muscle cell proliferation 79 82 2 2 1 1 0 0 38 82 2427 0.2857 1.0 0.63334 0.0 0 0 0 0 0 GO:0048662 7 negative regulation of smooth muscle cell proliferation 29 29 2 2 1 1 0 0 38 29 2480 0.64509 1.0 1.0 0.0 0 0 0 0 0 GO:0048791 6 calcium ion-regulated exocytosis of neurotransmitter 3 3 1 1 0 1 0 0 38 3 2506 0.95589 1.0 1.0 0.0 0 0 0 0 0 GO:0048871 4 multicellular organismal homeostasis 34 36 2 2 0 1 0 0 38 36 2473 0.57988 1.0 1.0 0.0 0 0 0 0 0 GO:0050000 5 chromosome localization 16 17 3 3 2 0 0 0 38 17 2492 0.77387 1.0 1.0 0.0 0 0 0 0 0 GO:0050433 6 regulation of catecholamine secretion 14 14 1 1 0 1 0 0 38 14 2495 0.80978 1.0 1.0 0.0 0 0 0 0 0 GO:0050657 7 nucleic acid transport 18 20 1 1 1 0 0 0 38 20 2489 0.73951 1.0 1.0 0.0 0 0 0 0 0 GO:0050658 5 RNA transport 18 20 1 1 1 0 0 0 38 20 2489 0.73951 1.0 1.0 0.0 0 0 0 0 0 GO:0050679 7 positive regulation of epithelial cell proliferation 67 70 2 1 1 1 0 0 38 70 2439 0.34409 1.0 0.62489 0.0 0 0 0 0 0 GO:0050684 7 regulation of mRNA processing 14 17 1 1 1 0 0 0 38 17 2492 0.77387 1.0 1.0 0.0 0 0 0 0 0 GO:0050685 8 positive regulation of mRNA processing 4 6 1 1 1 0 0 0 38 6 2503 0.91367 1.0 1.0 0.0 0 0 0 0 0 GO:0050773 9 regulation of dendrite development 40 44 1 1 0 1 0 0 38 44 2465 0.5132 1.0 1.0 0.0 0 0 0 0 0 GO:0050779 6 RNA destabilization 2 2 1 1 1 0 0 0 38 2 2507 0.97038 1.0 1.0 0.0 0 0 0 0 0 GO:0050804 6 modulation of chemical synaptic transmission 117 127 1 1 0 1 0 0 38 127 2382 0.1411 1.0 0.25912 0.0 0 0 0 0 0 GO:0050807 6 regulation of synapse organization 52 60 1 1 0 1 0 0 38 60 2449 0.40148 1.0 1.0 0.0 0 0 0 0 0 GO:0050891 4 multicellular organismal water homeostasis 11 11 1 1 0 0 0 0 38 11 2498 0.84732 1.0 1.0 0.0 0 0 0 0 0 GO:0050900 5 leukocyte migration 64 68 2 2 2 0 0 0 38 68 2441 0.35488 1.0 0.62448 0.0 0 0 0 0 0 GO:0050922 6 negative regulation of chemotaxis 10 12 1 1 0 1 0 0 38 12 2497 0.83462 1.0 1.0 0.0 0 0 0 0 0 GO:0051028 6 mRNA transport 14 15 1 1 1 0 0 0 38 15 2494 0.79763 1.0 1.0 0.0 0 0 0 0 0 GO:0051046 6 regulation of secretion 220 238 3 2 1 2 0 0 38 238 2271 0.023363 1.0 0.044661 0.0 0 0 0 0 0 GO:0051047 6 positive regulation of secretion 140 149 2 1 1 1 0 0 38 149 2360 0.099459 1.0 0.16706 0.0 0 0 0 0 0 GO:0051051 5 negative regulation of transport 140 146 1 0 0 1 0 0 38 146 2363 0.10434 1.0 0.16732 0.0 0 0 0 0 0 GO:0051081 7 nuclear envelope disassembly 3 3 1 1 0 1 0 0 38 3 2506 0.95589 1.0 1.0 0.0 0 0 0 0 0 GO:0051100 5 negative regulation of binding 52 53 1 1 1 0 0 0 38 53 2456 0.44709 1.0 1.0 0.0 0 0 0 0 0 GO:0051121 8 hepoxilin metabolic process 3 3 1 1 0 1 0 0 38 3 2506 0.95589 1.0 1.0 0.0 0 0 0 0 0 GO:0051122 8 hepoxilin biosynthetic process 3 3 1 1 0 1 0 0 38 3 2506 0.95589 1.0 1.0 0.0 0 0 0 0 0 GO:0051147 6 regulation of muscle cell differentiation 57 60 1 1 0 0 0 0 38 60 2449 0.40148 1.0 1.0 0.0 0 0 0 0 0 GO:0051149 7 positive regulation of muscle cell differentiation 27 30 1 1 0 0 0 0 38 30 2479 0.63536 1.0 1.0 0.0 0 0 0 0 0 GO:0051153 7 regulation of striated muscle cell differentiation 45 47 1 1 0 0 0 0 38 47 2462 0.49017 1.0 1.0 0.0 0 0 0 0 0 GO:0051155 8 positive regulation of striated muscle cell differentiation 23 25 1 1 0 0 0 0 38 25 2484 0.68551 1.0 1.0 0.0 0 0 0 0 0 GO:0051169 5 nuclear transport 37 41 1 1 1 0 0 0 38 41 2468 0.53728 1.0 1.0 0.0 0 0 0 0 0 GO:0051170 7 import into nucleus 23 24 1 1 1 0 0 0 38 24 2485 0.69599 1.0 1.0 0.0 0 0 0 0 0 GO:0051177 6 meiotic sister chromatid cohesion 4 4 1 1 0 1 0 0 38 4 2505 0.94161 1.0 1.0 0.0 0 0 0 0 0 GO:0051187 5 cofactor catabolic process 18 20 1 1 1 0 0 0 38 20 2489 0.73951 1.0 1.0 0.0 0 0 0 0 0 GO:0051236 4 establishment of RNA localization 18 20 1 1 1 0 0 0 38 20 2489 0.73951 1.0 1.0 0.0 0 0 0 0 0 GO:0051261 8 protein depolymerization 9 11 1 1 0 0 0 0 38 11 2498 0.84732 1.0 1.0 0.0 0 0 0 0 0 GO:0051293 6 establishment of spindle localization 10 10 2 2 1 1 0 0 38 10 2499 0.8602 1.0 1.0 0.0 0 0 0 0 0 GO:0051294 7 establishment of spindle orientation 8 8 1 1 0 1 0 0 38 8 2501 0.88655 1.0 1.0 0.0 0 0 0 0 0 GO:0051303 5 establishment of chromosome localization 16 17 3 3 2 0 0 0 38 17 2492 0.77387 1.0 1.0 0.0 0 0 0 0 0 GO:0051304 4 chromosome separation 3 3 1 1 1 0 0 0 38 3 2506 0.95589 1.0 1.0 0.0 0 0 0 0 0 GO:0051310 5 metaphase plate congression 15 16 3 3 2 0 0 0 38 16 2493 0.78566 1.0 1.0 0.0 0 0 0 0 0 GO:0051321 3 meiotic cell cycle 9 10 1 1 0 1 0 0 38 10 2499 0.8602 1.0 1.0 0.0 0 0 0 0 0 GO:0051354 6 negative regulation of oxidoreductase activity 12 12 1 1 0 1 0 0 38 12 2497 0.83462 1.0 1.0 0.0 0 0 0 0 0 GO:0051382 7 kinetochore assembly 5 5 1 1 0 1 0 0 38 5 2504 0.92754 1.0 1.0 0.0 0 0 0 0 0 GO:0051385 7 response to mineralocorticoid 32 37 1 1 1 0 0 0 38 37 2472 0.57111 1.0 1.0 0.0 0 0 0 0 0 GO:0051403 9 stress-activated MAPK cascade 16 17 1 1 1 0 0 0 38 17 2492 0.77387 1.0 1.0 0.0 0 0 0 0 0 GO:0051412 6 response to corticosterone 23 27 1 1 1 0 0 0 38 27 2482 0.665 1.0 1.0 0.0 0 0 0 0 0 GO:0051438 8 regulation of ubiquitin-protein transferase activity 15 16 2 2 0 2 0 0 38 16 2493 0.78566 1.0 1.0 0.0 0 0 0 0 0 GO:0051443 9 positive regulation of ubiquitin-protein transferase activity 9 9 2 2 0 2 0 0 38 9 2500 0.87328 1.0 1.0 0.0 0 0 0 0 0 GO:0051445 5 regulation of meiotic cell cycle 17 19 3 3 2 1 0 0 38 19 2490 0.75079 1.0 1.0 0.0 0 0 0 0 0 GO:0051446 6 positive regulation of meiotic cell cycle 11 11 1 1 0 1 0 0 38 11 2498 0.84732 1.0 1.0 0.0 0 0 0 0 0 GO:0051447 6 negative regulation of meiotic cell cycle 4 6 2 2 2 0 0 0 38 6 2503 0.91367 1.0 1.0 0.0 0 0 0 0 0 GO:0051494 8 negative regulation of cytoskeleton organization 28 32 2 1 0 1 0 0 38 32 2477 0.61632 1.0 1.0 0.0 0 0 0 0 0 GO:0051495 8 positive regulation of cytoskeleton organization 51 55 1 1 1 0 0 0 38 55 2454 0.43356 1.0 1.0 0.0 0 0 0 0 0 GO:0051653 4 spindle localization 12 12 2 2 1 1 0 0 38 12 2497 0.83462 1.0 1.0 0.0 0 0 0 0 0 GO:0051769 7 regulation of nitric-oxide synthase biosynthetic process 11 11 1 1 0 1 0 0 38 11 2498 0.84732 1.0 1.0 0.0 0 0 0 0 0 GO:0051771 8 negative regulation of nitric-oxide synthase biosynthetic process 3 3 1 1 0 1 0 0 38 3 2506 0.95589 1.0 1.0 0.0 0 0 0 0 0 GO:0051783 7 regulation of nuclear division 47 50 7 6 3 3 0 0 38 50 2459 0.46814 1.0 1.0 0.0 0 0 0 0 0 GO:0051784 8 negative regulation of nuclear division 15 15 2 2 1 1 0 0 38 15 2494 0.79763 1.0 1.0 0.0 0 0 0 0 0 GO:0051785 8 positive regulation of nuclear division 23 26 1 1 1 0 0 0 38 26 2483 0.67518 1.0 1.0 0.0 0 0 0 0 0 GO:0051865 10 protein autoubiquitination 13 13 1 1 0 0 0 0 38 13 2496 0.82211 1.0 1.0 0.0 0 0 0 0 0 GO:0051926 7 negative regulation of calcium ion transport 19 21 1 0 0 1 0 0 38 21 2488 0.72838 1.0 1.0 0.0 0 0 0 0 0 GO:0051952 6 regulation of amine transport 29 30 1 1 0 1 0 0 38 30 2479 0.63536 1.0 1.0 0.0 0 0 0 0 0 GO:0051984 6 positive regulation of chromosome segregation 10 10 2 1 1 0 0 0 38 10 2499 0.8602 1.0 1.0 0.0 0 0 0 0 0 GO:0051985 6 negative regulation of chromosome segregation 12 12 2 2 1 1 0 0 38 12 2497 0.83462 1.0 1.0 0.0 0 0 0 0 0 GO:0051987 7 positive regulation of attachment of spindle microtubules to kinetochore 4 4 1 1 1 0 0 0 38 4 2505 0.94161 1.0 1.0 0.0 0 0 0 0 0 GO:0052695 9 cellular glucuronidation 3 10 1 1 0 1 0 0 38 10 2499 0.8602 1.0 1.0 0.0 0 0 0 0 0 GO:0055001 5 muscle cell development 30 30 1 1 1 0 0 0 38 30 2479 0.63536 1.0 1.0 0.0 0 0 0 0 0 GO:0055002 6 striated muscle cell development 24 24 1 1 1 0 0 0 38 24 2485 0.69599 1.0 1.0 0.0 0 0 0 0 0 GO:0055006 5 cardiac cell development 13 13 1 1 1 0 0 0 38 13 2496 0.82211 1.0 1.0 0.0 0 0 0 0 0 GO:0055013 6 cardiac muscle cell development 11 11 1 1 1 0 0 0 38 11 2498 0.84732 1.0 1.0 0.0 0 0 0 0 0 GO:0055015 7 ventricular cardiac muscle cell development 3 3 1 1 1 0 0 0 38 3 2506 0.95589 1.0 1.0 0.0 0 0 0 0 0 GO:0055021 7 regulation of cardiac muscle tissue growth 28 29 1 1 1 0 0 0 38 29 2480 0.64509 1.0 1.0 0.0 0 0 0 0 0 GO:0055023 8 positive regulation of cardiac muscle tissue growth 16 17 1 1 1 0 0 0 38 17 2492 0.77387 1.0 1.0 0.0 0 0 0 0 0 GO:0055024 7 regulation of cardiac muscle tissue development 35 37 1 1 1 0 0 0 38 37 2472 0.57111 1.0 1.0 0.0 0 0 0 0 0 GO:0055025 8 positive regulation of cardiac muscle tissue development 20 22 1 1 1 0 0 0 38 22 2487 0.71743 1.0 1.0 0.0 0 0 0 0 0 GO:0055088 6 lipid homeostasis 50 52 1 1 0 1 0 0 38 52 2457 0.454 1.0 1.0 0.0 0 0 0 0 0 GO:0060043 6 regulation of cardiac muscle cell proliferation 14 15 1 1 1 0 0 0 38 15 2494 0.79763 1.0 1.0 0.0 0 0 0 0 0 GO:0060045 7 positive regulation of cardiac muscle cell proliferation 8 9 1 1 1 0 0 0 38 9 2500 0.87328 1.0 1.0 0.0 0 0 0 0 0 GO:0060046 6 regulation of acrosome reaction 4 4 1 0 0 1 0 0 38 4 2505 0.94161 1.0 1.0 0.0 0 0 0 0 0 GO:0060147 7 regulation of posttranscriptional gene silencing 13 15 1 1 1 0 0 0 38 15 2494 0.79763 1.0 1.0 0.0 0 0 0 0 0 GO:0060148 5 positive regulation of posttranscriptional gene silencing 9 10 1 1 1 0 0 0 38 10 2499 0.8602 1.0 1.0 0.0 0 0 0 0 0 GO:0060211 9 regulation of nuclear-transcribed mRNA poly(A) tail shortening 3 3 1 1 1 0 0 0 38 3 2506 0.95589 1.0 1.0 0.0 0 0 0 0 0 GO:0060213 10 positive regulation of nuclear-transcribed mRNA poly(A) tail shortening 2 2 1 1 1 0 0 0 38 2 2507 0.97038 1.0 1.0 0.0 0 0 0 0 0 GO:0060236 7 regulation of mitotic spindle organization 10 10 1 1 0 1 0 0 38 10 2499 0.8602 1.0 1.0 0.0 0 0 0 0 0 GO:0060271 7 cilium assembly 15 16 1 1 0 0 0 0 38 16 2493 0.78566 1.0 1.0 0.0 0 0 0 0 0 GO:0060281 6 regulation of oocyte development 12 13 2 2 1 1 0 0 38 13 2496 0.82211 1.0 1.0 0.0 0 0 0 0 0 GO:0060282 7 positive regulation of oocyte development 7 7 1 1 0 1 0 0 38 7 2502 0.90001 1.0 1.0 0.0 0 0 0 0 0 GO:0060283 7 negative regulation of oocyte development 5 6 1 1 1 0 0 0 38 6 2503 0.91367 1.0 1.0 0.0 0 0 0 0 0 GO:0060349 5 bone morphogenesis 7 7 1 1 0 0 0 0 38 7 2502 0.90001 1.0 1.0 0.0 0 0 0 0 0 GO:0060420 6 regulation of heart growth 30 31 1 1 1 0 0 0 38 31 2478 0.62577 1.0 1.0 0.0 0 0 0 0 0 GO:0060421 7 positive regulation of heart growth 16 17 1 1 1 0 0 0 38 17 2492 0.77387 1.0 1.0 0.0 0 0 0 0 0 GO:0060456 6 positive regulation of digestive system process 3 4 1 0 0 1 0 0 38 4 2505 0.94161 1.0 1.0 0.0 0 0 0 0 0 GO:0060574 7 intestinal epithelial cell maturation 3 4 1 1 1 0 0 0 38 4 2505 0.94161 1.0 1.0 0.0 0 0 0 0 0 GO:0060623 8 regulation of chromosome condensation 1 1 1 1 1 0 0 0 38 1 2508 0.98508 1.0 1.0 0.0 0 0 0 0 0 GO:0060627 5 regulation of vesicle-mediated transport 135 149 1 1 0 1 0 0 38 149 2360 0.099459 1.0 0.16706 0.0 0 0 0 0 0 GO:0060856 5 establishment of blood-brain barrier 4 4 1 1 1 0 0 0 38 4 2505 0.94161 1.0 1.0 0.0 0 0 0 0 0 GO:0060857 6 establishment of glial blood-brain barrier 1 1 1 1 1 0 0 0 38 1 2508 0.98508 1.0 1.0 0.0 0 0 0 0 0 GO:0060964 7 regulation of gene silencing by miRNA 12 14 1 1 1 0 0 0 38 14 2495 0.80978 1.0 1.0 0.0 0 0 0 0 0 GO:0060966 6 regulation of gene silencing by RNA 13 15 1 1 1 0 0 0 38 15 2494 0.79763 1.0 1.0 0.0 0 0 0 0 0 GO:0060968 5 regulation of gene silencing 15 18 1 1 1 0 0 0 38 18 2491 0.76224 1.0 1.0 0.0 0 0 0 0 0 GO:0061013 7 regulation of mRNA catabolic process 16 17 1 1 1 0 0 0 38 17 2492 0.77387 1.0 1.0 0.0 0 0 0 0 0 GO:0061014 8 positive regulation of mRNA catabolic process 3 3 1 1 1 0 0 0 38 3 2506 0.95589 1.0 1.0 0.0 0 0 0 0 0 GO:0061045 7 negative regulation of wound healing 33 35 1 1 1 0 0 0 38 35 2474 0.58879 1.0 1.0 0.0 0 0 0 0 0 GO:0061157 7 mRNA destabilization 2 2 1 1 1 0 0 0 38 2 2507 0.97038 1.0 1.0 0.0 0 0 0 0 0 GO:0061158 8 3'-UTR-mediated mRNA destabilization 1 1 1 1 1 0 0 0 38 1 2508 0.98508 1.0 1.0 0.0 0 0 0 0 0 GO:0061436 6 establishment of skin barrier 6 6 1 1 0 0 0 0 38 6 2503 0.91367 1.0 1.0 0.0 0 0 0 0 0 GO:0061469 7 regulation of type B pancreatic cell proliferation 3 4 1 1 1 0 0 0 38 4 2505 0.94161 1.0 1.0 0.0 0 0 0 0 0 GO:0062014 6 negative regulation of small molecule metabolic process 34 38 1 0 0 0 0 0 38 38 2471 0.56246 1.0 1.0 0.0 0 0 0 0 0 GO:0070085 3 glycosylation 35 36 2 2 0 2 0 0 38 36 2473 0.57988 1.0 1.0 0.0 0 0 0 0 0 GO:0070192 5 chromosome organization involved in meiotic cell cycle 10 10 1 1 0 1 0 0 38 10 2499 0.8602 1.0 1.0 0.0 0 0 0 0 0 GO:0070193 7 synaptonemal complex organization 2 2 1 1 0 1 0 0 38 2 2507 0.97038 1.0 1.0 0.0 0 0 0 0 0 GO:0070194 6 synaptonemal complex disassembly 2 2 1 1 0 1 0 0 38 2 2507 0.97038 1.0 1.0 0.0 0 0 0 0 0 GO:0070268 5 cornification 1 1 1 1 0 0 0 0 38 1 2508 0.98508 1.0 1.0 0.0 0 0 0 0 0 GO:0070293 5 renal absorption 4 4 1 1 1 0 0 0 38 4 2505 0.94161 1.0 1.0 0.0 0 0 0 0 0 GO:0070302 6 regulation of stress-activated protein kinase signaling cascade 57 61 2 2 0 1 0 0 38 61 2448 0.39534 1.0 1.0 0.0 0 0 0 0 0 GO:0070303 7 negative regulation of stress-activated protein kinase signaling cascade 7 7 2 2 0 1 0 0 38 7 2502 0.90001 1.0 1.0 0.0 0 0 0 0 0 GO:0070372 8 regulation of ERK1 and ERK2 cascade 108 115 1 1 0 1 0 0 38 115 2394 0.17053 1.0 0.41498 0.0 0 0 0 0 0 GO:0070373 9 negative regulation of ERK1 and ERK2 cascade 25 27 1 1 0 1 0 0 38 27 2482 0.665 1.0 1.0 0.0 0 0 0 0 0 GO:0070486 6 leukocyte aggregation 8 8 1 1 1 0 0 0 38 8 2501 0.88655 1.0 1.0 0.0 0 0 0 0 0 GO:0070488 7 neutrophil aggregation 2 2 1 1 1 0 0 0 38 2 2507 0.97038 1.0 1.0 0.0 0 0 0 0 0 GO:0070534 11 protein K63-linked ubiquitination 5 5 1 1 0 0 0 0 38 5 2504 0.92754 1.0 1.0 0.0 0 0 0 0 0 GO:0070601 6 centromeric sister chromatid cohesion 3 3 1 1 0 1 0 0 38 3 2506 0.95589 1.0 1.0 0.0 0 0 0 0 0 GO:0070646 7 protein modification by small protein removal 13 13 1 0 1 0 0 0 38 13 2496 0.82211 1.0 1.0 0.0 0 0 0 0 0 GO:0070727 4 cellular macromolecule localization 185 196 3 3 2 1 0 0 38 196 2313 0.046602 1.0 0.11361 0.0 0 0 0 0 0 GO:0070848 5 response to growth factor 153 159 4 4 2 2 0 0 38 159 2350 0.08475 1.0 0.16911 0.0 0 0 0 0 0 GO:0070849 4 response to epidermal growth factor 25 26 2 2 1 1 0 0 38 26 2483 0.67518 1.0 1.0 0.0 0 0 0 0 0 GO:0070935 8 3'-UTR-mediated mRNA stabilization 5 5 1 1 1 0 0 0 38 5 2504 0.92754 1.0 1.0 0.0 0 0 0 0 0 GO:0070936 11 protein K48-linked ubiquitination 11 11 1 1 0 0 0 0 38 11 2498 0.84732 1.0 1.0 0.0 0 0 0 0 0 GO:0070979 11 protein K11-linked ubiquitination 3 3 1 1 0 0 0 0 38 3 2506 0.95589 1.0 1.0 0.0 0 0 0 0 0 GO:0071158 8 positive regulation of cell cycle arrest 13 13 1 1 1 0 0 0 38 13 2496 0.82211 1.0 1.0 0.0 0 0 0 0 0 GO:0071168 8 protein localization to chromatin 7 7 1 1 0 1 0 0 38 7 2502 0.90001 1.0 1.0 0.0 0 0 0 0 0 GO:0071173 8 spindle assembly checkpoint 9 9 2 2 1 1 0 0 38 9 2500 0.87328 1.0 1.0 0.0 0 0 0 0 0 GO:0071174 8 mitotic spindle checkpoint 9 9 2 2 1 1 0 0 38 9 2500 0.87328 1.0 1.0 0.0 0 0 0 0 0 GO:0071281 7 cellular response to iron ion 8 9 1 1 1 0 0 0 38 9 2500 0.87328 1.0 1.0 0.0 0 0 0 0 0 GO:0071283 8 cellular response to iron(III) ion 2 3 1 1 1 0 0 0 38 3 2506 0.95589 1.0 1.0 0.0 0 0 0 0 0 GO:0071300 6 cellular response to retinoic acid 19 22 1 1 0 0 0 0 38 22 2487 0.71743 1.0 1.0 0.0 0 0 0 0 0 GO:0071312 6 cellular response to alkaloid 21 22 1 1 0 1 0 0 38 22 2487 0.71743 1.0 1.0 0.0 0 0 0 0 0 GO:0071314 6 cellular response to cocaine 1 1 1 1 0 1 0 0 38 1 2508 0.98508 1.0 1.0 0.0 0 0 0 0 0 GO:0071356 7 cellular response to tumor necrosis factor 67 70 1 1 1 0 0 0 38 70 2439 0.34409 1.0 0.62489 0.0 0 0 0 0 0 GO:0071363 6 cellular response to growth factor stimulus 136 141 4 4 2 2 0 0 38 141 2368 0.11299 1.0 0.26871 0.0 0 0 0 0 0 GO:0071364 6 cellular response to epidermal growth factor stimulus 19 20 2 2 1 1 0 0 38 20 2489 0.73951 1.0 1.0 0.0 0 0 0 0 0 GO:0071371 6 cellular response to gonadotropin stimulus 23 25 1 1 0 1 0 0 38 25 2484 0.68551 1.0 1.0 0.0 0 0 0 0 0 GO:0071373 7 cellular response to luteinizing hormone stimulus 5 6 1 1 0 1 0 0 38 6 2503 0.91367 1.0 1.0 0.0 0 0 0 0 0 GO:0071376 7 cellular response to corticotropin-releasing hormone stimulus 2 2 1 1 1 0 0 0 38 2 2507 0.97038 1.0 1.0 0.0 0 0 0 0 0 GO:0071453 5 cellular response to oxygen levels 66 69 2 2 1 1 0 0 38 69 2440 0.34944 1.0 0.62464 0.0 0 0 0 0 0 GO:0071456 5 cellular response to hypoxia 57 60 2 2 1 1 0 0 38 60 2449 0.40148 1.0 1.0 0.0 0 0 0 0 0 GO:0071459 8 protein localization to chromosome, centromeric region 8 10 1 1 1 0 0 0 38 10 2499 0.8602 1.0 1.0 0.0 0 0 0 0 0 GO:0071460 5 cellular response to cell-matrix adhesion 3 3 1 1 0 1 0 0 38 3 2506 0.95589 1.0 1.0 0.0 0 0 0 0 0 GO:0071466 5 cellular response to xenobiotic stimulus 51 53 2 1 0 1 0 0 38 53 2456 0.44709 1.0 1.0 0.0 0 0 0 0 0 GO:0071480 7 cellular response to gamma radiation 15 15 1 1 1 0 0 0 38 15 2494 0.79763 1.0 1.0 0.0 0 0 0 0 0 GO:0071482 6 cellular response to light stimulus 37 39 2 2 1 0 0 0 38 39 2470 0.55394 1.0 1.0 0.0 0 0 0 0 0 GO:0071493 8 cellular response to UV-B 3 4 1 1 1 0 0 0 38 4 2505 0.94161 1.0 1.0 0.0 0 0 0 0 0 GO:0071548 6 response to dexamethasone 48 52 1 0 0 0 0 0 38 52 2457 0.454 1.0 1.0 0.0 0 0 0 0 0 GO:0071549 7 cellular response to dexamethasone stimulus 35 36 1 0 0 0 0 0 38 36 2473 0.57988 1.0 1.0 0.0 0 0 0 0 0 GO:0071621 7 granulocyte chemotaxis 33 34 1 1 1 0 0 0 38 34 2475 0.59783 1.0 1.0 0.0 0 0 0 0 0 GO:0071637 7 regulation of monocyte chemotactic protein-1 production 8 8 1 1 0 1 0 0 38 8 2501 0.88655 1.0 1.0 0.0 0 0 0 0 0 GO:0071638 8 negative regulation of monocyte chemotactic protein-1 production 3 3 1 1 0 1 0 0 38 3 2506 0.95589 1.0 1.0 0.0 0 0 0 0 0 GO:0071671 6 regulation of smooth muscle cell chemotaxis 3 3 1 1 0 1 0 0 38 3 2506 0.95589 1.0 1.0 0.0 0 0 0 0 0 GO:0071672 7 negative regulation of smooth muscle cell chemotaxis 2 2 1 1 0 1 0 0 38 2 2507 0.97038 1.0 1.0 0.0 0 0 0 0 0 GO:0071684 3 organism emergence from protective structure 6 6 1 1 1 0 0 0 38 6 2503 0.91367 1.0 1.0 0.0 0 0 0 0 0 GO:0071695 4 anatomical structure maturation 44 46 3 2 2 1 0 0 38 46 2463 0.49773 1.0 1.0 0.0 0 0 0 0 0 GO:0071731 5 response to nitric oxide 10 10 1 1 0 1 0 0 38 10 2499 0.8602 1.0 1.0 0.0 0 0 0 0 0 GO:0071732 6 cellular response to nitric oxide 7 7 1 1 0 1 0 0 38 7 2502 0.90001 1.0 1.0 0.0 0 0 0 0 0 GO:0071774 4 response to fibroblast growth factor 28 30 2 2 2 0 0 0 38 30 2479 0.63536 1.0 1.0 0.0 0 0 0 0 0 GO:0071850 7 mitotic cell cycle arrest 4 4 1 1 1 0 0 0 38 4 2505 0.94161 1.0 1.0 0.0 0 0 0 0 0 GO:0071897 6 DNA biosynthetic process 14 18 1 1 1 0 0 0 38 18 2491 0.76224 1.0 1.0 0.0 0 0 0 0 0 GO:0071900 8 regulation of protein serine/threonine kinase activity 142 154 8 6 2 4 0 0 38 154 2355 0.091818 1.0 0.16754 0.0 0 0 0 0 0 GO:0071901 9 negative regulation of protein serine/threonine kinase activity 40 43 3 3 1 2 0 0 38 43 2466 0.52111 1.0 1.0 0.0 0 0 0 0 0 GO:0071902 9 positive regulation of protein serine/threonine kinase activity 93 101 3 2 1 1 0 0 38 101 2408 0.21244 1.0 0.40172 0.0 0 0 0 0 0 GO:0071962 7 mitotic sister chromatid cohesion, centromeric 1 1 1 1 0 1 0 0 38 1 2508 0.98508 1.0 1.0 0.0 0 0 0 0 0 GO:0072329 7 monocarboxylic acid catabolic process 43 48 1 1 0 0 0 0 38 48 2461 0.48272 1.0 1.0 0.0 0 0 0 0 0 GO:0072331 6 signal transduction by p53 class mediator 28 29 2 1 1 0 0 0 38 29 2480 0.64509 1.0 1.0 0.0 0 0 0 0 0 GO:0072332 7 intrinsic apoptotic signaling pathway by p53 class mediator 19 19 2 1 1 0 0 0 38 19 2490 0.75079 1.0 1.0 0.0 0 0 0 0 0 GO:0072395 6 signal transduction involved in cell cycle checkpoint 10 10 2 2 1 1 0 0 38 10 2499 0.8602 1.0 1.0 0.0 0 0 0 0 0 GO:0072401 7 signal transduction involved in DNA integrity checkpoint 10 10 2 2 1 1 0 0 38 10 2499 0.8602 1.0 1.0 0.0 0 0 0 0 0 GO:0072413 7 signal transduction involved in mitotic cell cycle checkpoint 6 6 1 1 1 0 0 0 38 6 2503 0.91367 1.0 1.0 0.0 0 0 0 0 0 GO:0072422 7 signal transduction involved in DNA damage checkpoint 10 10 2 2 1 1 0 0 38 10 2499 0.8602 1.0 1.0 0.0 0 0 0 0 0 GO:0072425 8 signal transduction involved in G2 DNA damage checkpoint 4 4 1 1 0 1 0 0 38 4 2505 0.94161 1.0 1.0 0.0 0 0 0 0 0 GO:0072431 9 signal transduction involved in mitotic G1 DNA damage checkpoint 5 5 1 1 1 0 0 0 38 5 2504 0.92754 1.0 1.0 0.0 0 0 0 0 0 GO:0072594 6 establishment of protein localization to organelle 64 68 1 1 1 0 0 0 38 68 2441 0.35488 1.0 0.62448 0.0 0 0 0 0 0 GO:0072676 6 lymphocyte migration 27 28 1 1 1 0 0 0 38 28 2481 0.65498 1.0 1.0 0.0 0 0 0 0 0 GO:0072698 8 protein localization to microtubule cytoskeleton 7 7 1 1 1 0 0 0 38 7 2502 0.90001 1.0 1.0 0.0 0 0 0 0 0 GO:0080154 5 regulation of fertilization 4 4 1 0 0 1 0 0 38 4 2505 0.94161 1.0 1.0 0.0 0 0 0 0 0 GO:0085020 11 protein K6-linked ubiquitination 2 2 1 1 0 0 0 0 38 2 2507 0.97038 1.0 1.0 0.0 0 0 0 0 0 GO:0090102 4 cochlea development 12 12 1 1 0 1 0 0 38 12 2497 0.83462 1.0 1.0 0.0 0 0 0 0 0 GO:0090128 7 regulation of synapse maturation 5 5 1 1 0 1 0 0 38 5 2504 0.92754 1.0 1.0 0.0 0 0 0 0 0 GO:0090129 7 positive regulation of synapse maturation 2 2 1 1 0 1 0 0 38 2 2507 0.97038 1.0 1.0 0.0 0 0 0 0 0 GO:0090169 7 regulation of spindle assembly 6 6 1 1 0 1 0 0 38 6 2503 0.91367 1.0 1.0 0.0 0 0 0 0 0 GO:0090186 5 regulation of pancreatic juice secretion 3 3 1 0 0 1 0 0 38 3 2506 0.95589 1.0 1.0 0.0 0 0 0 0 0 GO:0090187 6 positive regulation of pancreatic juice secretion 2 2 1 0 0 1 0 0 38 2 2507 0.97038 1.0 1.0 0.0 0 0 0 0 0 GO:0090224 7 regulation of spindle organization 11 11 1 1 0 1 0 0 38 11 2498 0.84732 1.0 1.0 0.0 0 0 0 0 0 GO:0090231 7 regulation of spindle checkpoint 3 3 1 1 1 0 0 0 38 3 2506 0.95589 1.0 1.0 0.0 0 0 0 0 0 GO:0090266 8 regulation of mitotic cell cycle spindle assembly checkpoint 3 3 1 1 1 0 0 0 38 3 2506 0.95589 1.0 1.0 0.0 0 0 0 0 0 GO:0090276 6 regulation of peptide hormone secretion 58 63 1 0 0 1 0 0 38 63 2446 0.38335 1.0 1.0 0.0 0 0 0 0 0 GO:0090277 7 positive regulation of peptide hormone secretion 36 38 1 0 0 1 0 0 38 38 2471 0.56246 1.0 1.0 0.0 0 0 0 0 0 GO:0090281 8 negative regulation of calcium ion import 4 5 1 0 0 1 0 0 38 5 2504 0.92754 1.0 1.0 0.0 0 0 0 0 0 GO:0090307 6 mitotic spindle assembly 10 10 1 1 0 1 0 0 38 10 2499 0.8602 1.0 1.0 0.0 0 0 0 0 0 GO:0090329 9 regulation of DNA-dependent DNA replication 14 15 1 1 1 0 0 0 38 15 2494 0.79763 1.0 1.0 0.0 0 0 0 0 0 GO:0090398 5 cellular senescence 15 15 1 1 1 0 0 0 38 15 2494 0.79763 1.0 1.0 0.0 0 0 0 0 0 GO:0090399 5 replicative senescence 5 5 1 1 1 0 0 0 38 5 2504 0.92754 1.0 1.0 0.0 0 0 0 0 0 GO:0090435 8 protein localization to nuclear envelope 1 1 1 1 0 1 0 0 38 1 2508 0.98508 1.0 1.0 0.0 0 0 0 0 0 GO:0090596 5 sensory organ morphogenesis 17 17 1 1 0 0 0 0 38 17 2492 0.77387 1.0 1.0 0.0 0 0 0 0 0 GO:0097009 5 energy homeostasis 9 10 1 1 0 1 0 0 38 10 2499 0.8602 1.0 1.0 0.0 0 0 0 0 0 GO:0097011 7 cellular response to granulocyte macrophage colony-stimulating factor stimulus 5 5 1 1 1 0 0 0 38 5 2504 0.92754 1.0 1.0 0.0 0 0 0 0 0 GO:0097012 6 response to granulocyte macrophage colony-stimulating factor 5 5 1 1 1 0 0 0 38 5 2504 0.92754 1.0 1.0 0.0 0 0 0 0 0 GO:0097366 5 response to bronchodilator 29 31 1 1 0 1 0 0 38 31 2478 0.62577 1.0 1.0 0.0 0 0 0 0 0 GO:0097384 5 cellular lipid biosynthetic process 2 2 1 1 0 0 0 0 38 2 2507 0.97038 1.0 1.0 0.0 0 0 0 0 0 GO:0097502 4 mannosylation 4 5 1 1 0 1 0 0 38 5 2504 0.92754 1.0 1.0 0.0 0 0 0 0 0 GO:0097503 6 sialylation 5 5 1 1 0 1 0 0 38 5 2504 0.92754 1.0 1.0 0.0 0 0 0 0 0 GO:0097529 6 myeloid leukocyte migration 42 43 1 1 1 0 0 0 38 43 2466 0.52111 1.0 1.0 0.0 0 0 0 0 0 GO:0097530 7 granulocyte migration 35 36 1 1 1 0 0 0 38 36 2473 0.57988 1.0 1.0 0.0 0 0 0 0 0 GO:0097742 6 de novo centriole assembly 1 1 1 1 1 0 0 0 38 1 2508 0.98508 1.0 1.0 0.0 0 0 0 0 0 GO:0098534 5 centriole assembly 5 5 1 1 1 0 0 0 38 5 2504 0.92754 1.0 1.0 0.0 0 0 0 0 0 GO:0098535 7 de novo centriole assembly involved in multi-ciliated epithelial cell differentiation 1 1 1 1 1 0 0 0 38 1 2508 0.98508 1.0 1.0 0.0 0 0 0 0 0 GO:0099003 5 vesicle-mediated transport in synapse 19 21 1 1 0 1 0 0 38 21 2488 0.72838 1.0 1.0 0.0 0 0 0 0 0 GO:0099177 5 regulation of trans-synaptic signaling 117 127 1 1 0 1 0 0 38 127 2382 0.1411 1.0 0.25912 0.0 0 0 0 0 0 GO:0099643 7 signal release from synapse 11 11 1 1 0 1 0 0 38 11 2498 0.84732 1.0 1.0 0.0 0 0 0 0 0 GO:0120031 7 plasma membrane bounded cell projection assembly 36 38 1 1 0 0 0 0 38 38 2471 0.56246 1.0 1.0 0.0 0 0 0 0 0 GO:0140238 5 presynaptic endocytosis 9 11 1 1 0 1 0 0 38 11 2498 0.84732 1.0 1.0 0.0 0 0 0 0 0 GO:0140352 4 export from cell 85 90 1 1 0 1 0 0 38 90 2419 0.25227 1.0 0.64349 0.0 0 0 0 0 0 GO:1900003 8 regulation of serine-type endopeptidase activity 2 2 1 0 0 1 0 0 38 2 2507 0.97038 1.0 1.0 0.0 0 0 0 0 0 GO:1900004 9 negative regulation of serine-type endopeptidase activity 2 2 1 0 0 1 0 0 38 2 2507 0.97038 1.0 1.0 0.0 0 0 0 0 0 GO:1900151 8 regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 3 3 1 1 1 0 0 0 38 3 2506 0.95589 1.0 1.0 0.0 0 0 0 0 0 GO:1900153 9 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 2 2 1 1 1 0 0 0 38 2 2507 0.97038 1.0 1.0 0.0 0 0 0 0 0 GO:1900193 7 regulation of oocyte maturation 11 12 2 2 1 1 0 0 38 12 2497 0.83462 1.0 1.0 0.0 0 0 0 0 0 GO:1900194 8 negative regulation of oocyte maturation 4 5 1 1 1 0 0 0 38 5 2504 0.92754 1.0 1.0 0.0 0 0 0 0 0 GO:1900195 8 positive regulation of oocyte maturation 7 7 1 1 0 1 0 0 38 7 2502 0.90001 1.0 1.0 0.0 0 0 0 0 0 GO:1900542 7 regulation of purine nucleotide metabolic process 30 32 1 0 0 0 0 0 38 32 2477 0.61632 1.0 1.0 0.0 0 0 0 0 0 GO:1900543 8 negative regulation of purine nucleotide metabolic process 8 8 1 0 0 0 0 0 38 8 2501 0.88655 1.0 1.0 0.0 0 0 0 0 0 GO:1901655 6 cellular response to ketone 66 69 1 0 0 0 0 0 38 69 2440 0.34944 1.0 0.62464 0.0 0 0 0 0 0 GO:1901673 8 regulation of mitotic spindle assembly 5 5 1 1 0 1 0 0 38 5 2504 0.92754 1.0 1.0 0.0 0 0 0 0 0 GO:1901685 5 glutathione derivative metabolic process 1 3 1 1 0 1 0 0 38 3 2506 0.95589 1.0 1.0 0.0 0 0 0 0 0 GO:1901687 6 glutathione derivative biosynthetic process 1 3 1 1 0 1 0 0 38 3 2506 0.95589 1.0 1.0 0.0 0 0 0 0 0 GO:1901799 10 negative regulation of proteasomal protein catabolic process 10 10 1 1 0 0 0 0 38 10 2499 0.8602 1.0 1.0 0.0 0 0 0 0 0 GO:1901834 8 regulation of deadenylation-independent decapping of nuclear-transcribed mRNA 1 1 1 1 1 0 0 0 38 1 2508 0.98508 1.0 1.0 0.0 0 0 0 0 0 GO:1901835 9 positive regulation of deadenylation-independent decapping of nuclear-transcribed mRNA 1 1 1 1 1 0 0 0 38 1 2508 0.98508 1.0 1.0 0.0 0 0 0 0 0 GO:1901857 7 positive regulation of cellular respiration 8 9 1 1 1 0 0 0 38 9 2500 0.87328 1.0 1.0 0.0 0 0 0 0 0 GO:1901861 5 regulation of muscle tissue development 56 58 4 4 1 1 0 0 38 58 2451 0.41402 1.0 1.0 0.0 0 0 0 0 0 GO:1901863 6 positive regulation of muscle tissue development 31 33 2 2 1 0 0 0 38 33 2476 0.607 1.0 1.0 0.0 0 0 0 0 0 GO:1901879 7 regulation of protein depolymerization 15 16 1 1 0 1 0 0 38 16 2493 0.78566 1.0 1.0 0.0 0 0 0 0 0 GO:1901880 8 negative regulation of protein depolymerization 12 13 1 1 0 1 0 0 38 13 2496 0.82211 1.0 1.0 0.0 0 0 0 0 0 GO:1901976 6 regulation of cell cycle checkpoint 6 6 1 1 1 0 0 0 38 6 2503 0.91367 1.0 1.0 0.0 0 0 0 0 0 GO:1901988 8 negative regulation of cell cycle phase transition 40 41 5 4 3 1 0 0 38 41 2468 0.53728 1.0 1.0 0.0 0 0 0 0 0 GO:1901991 8 negative regulation of mitotic cell cycle phase transition 37 38 5 4 3 1 0 0 38 38 2471 0.56246 1.0 1.0 0.0 0 0 0 0 0 GO:1901993 6 regulation of meiotic cell cycle phase transition 3 3 1 1 1 0 0 0 38 3 2506 0.95589 1.0 1.0 0.0 0 0 0 0 0 GO:1901994 7 negative regulation of meiotic cell cycle phase transition 1 1 1 1 1 0 0 0 38 1 2508 0.98508 1.0 1.0 0.0 0 0 0 0 0 GO:1902099 7 regulation of metaphase/anaphase transition of cell cycle 15 15 4 3 2 1 0 0 38 15 2494 0.79763 1.0 1.0 0.0 0 0 0 0 0 GO:1902100 8 negative regulation of metaphase/anaphase transition of cell cycle 10 10 2 2 1 1 0 0 38 10 2499 0.8602 1.0 1.0 0.0 0 0 0 0 0 GO:1902102 7 regulation of metaphase/anaphase transition of meiotic cell cycle 1 1 1 1 1 0 0 0 38 1 2508 0.98508 1.0 1.0 0.0 0 0 0 0 0 GO:1902103 8 negative regulation of metaphase/anaphase transition of meiotic cell cycle 1 1 1 1 1 0 0 0 38 1 2508 0.98508 1.0 1.0 0.0 0 0 0 0 0 GO:1902115 6 regulation of organelle assembly 42 45 2 2 1 1 0 0 38 45 2464 0.50541 1.0 1.0 0.0 0 0 0 0 0 GO:1902117 7 positive regulation of organelle assembly 16 18 1 1 1 0 0 0 38 18 2491 0.76224 1.0 1.0 0.0 0 0 0 0 0 GO:1902170 6 cellular response to reactive nitrogen species 9 9 1 1 0 1 0 0 38 9 2500 0.87328 1.0 1.0 0.0 0 0 0 0 0 GO:1902172 9 regulation of keratinocyte apoptotic process 1 1 1 1 1 0 0 0 38 1 2508 0.98508 1.0 1.0 0.0 0 0 0 0 0 GO:1902275 8 regulation of chromatin organization 37 37 2 2 1 1 0 0 38 37 2472 0.57111 1.0 1.0 0.0 0 0 0 0 0 GO:1902369 8 negative regulation of RNA catabolic process 11 11 1 1 1 0 0 0 38 11 2498 0.84732 1.0 1.0 0.0 0 0 0 0 0 GO:1902373 8 negative regulation of mRNA catabolic process 11 11 1 1 1 0 0 0 38 11 2498 0.84732 1.0 1.0 0.0 0 0 0 0 0 GO:1902400 8 intracellular signal transduction involved in G1 DNA damage checkpoint 5 5 1 1 1 0 0 0 38 5 2504 0.92754 1.0 1.0 0.0 0 0 0 0 0 GO:1902402 8 signal transduction involved in mitotic DNA damage checkpoint 6 6 1 1 1 0 0 0 38 6 2503 0.91367 1.0 1.0 0.0 0 0 0 0 0 GO:1902403 8 signal transduction involved in mitotic DNA integrity checkpoint 6 6 1 1 1 0 0 0 38 6 2503 0.91367 1.0 1.0 0.0 0 0 0 0 0 GO:1902532 7 negative regulation of intracellular signal transduction 138 146 4 2 0 2 0 0 38 146 2363 0.10434 1.0 0.16732 0.0 0 0 0 0 0 GO:1902571 7 regulation of serine-type peptidase activity 2 2 1 0 0 1 0 0 38 2 2507 0.97038 1.0 1.0 0.0 0 0 0 0 0 GO:1902572 8 negative regulation of serine-type peptidase activity 2 2 1 0 0 1 0 0 38 2 2507 0.97038 1.0 1.0 0.0 0 0 0 0 0 GO:1902749 8 regulation of cell cycle G2/M phase transition 30 32 6 5 3 1 0 0 38 32 2477 0.61632 1.0 1.0 0.0 0 0 0 0 0 GO:1902750 9 negative regulation of cell cycle G2/M phase transition 15 16 4 3 2 1 0 0 38 16 2493 0.78566 1.0 1.0 0.0 0 0 0 0 0 GO:1902751 9 positive regulation of cell cycle G2/M phase transition 12 13 1 1 1 0 0 0 38 13 2496 0.82211 1.0 1.0 0.0 0 0 0 0 0 GO:1902807 9 negative regulation of cell cycle G1/S phase transition 19 19 1 1 1 0 0 0 38 19 2490 0.75079 1.0 1.0 0.0 0 0 0 0 0 GO:1902809 7 regulation of skeletal muscle fiber differentiation 1 1 1 1 0 0 0 0 38 1 2508 0.98508 1.0 1.0 0.0 0 0 0 0 0 GO:1902811 8 positive regulation of skeletal muscle fiber differentiation 1 1 1 1 0 0 0 0 38 1 2508 0.98508 1.0 1.0 0.0 0 0 0 0 0 GO:1902903 6 regulation of supramolecular fiber organization 89 94 1 1 0 1 0 0 38 94 2415 0.23701 1.0 0.40015 0.0 0 0 0 0 0 GO:1902904 7 negative regulation of supramolecular fiber organization 31 35 1 1 0 1 0 0 38 35 2474 0.58879 1.0 1.0 0.0 0 0 0 0 0 GO:1903035 6 negative regulation of response to wounding 34 36 1 1 1 0 0 0 38 36 2473 0.57988 1.0 1.0 0.0 0 0 0 0 0 GO:1903051 9 negative regulation of proteolysis involved in cellular protein catabolic process 15 15 1 1 0 0 0 0 38 15 2494 0.79763 1.0 1.0 0.0 0 0 0 0 0 GO:1903096 10 protein localization to meiotic spindle midzone 1 1 1 1 1 0 0 0 38 1 2508 0.98508 1.0 1.0 0.0 0 0 0 0 0 GO:1903131 6 mononuclear cell differentiation 8 8 1 1 1 0 0 0 38 8 2501 0.88655 1.0 1.0 0.0 0 0 0 0 0 GO:1903305 7 regulation of regulated secretory pathway 36 42 1 1 0 1 0 0 38 42 2467 0.52913 1.0 1.0 0.0 0 0 0 0 0 GO:1903311 7 regulation of mRNA metabolic process 28 31 2 2 2 0 0 0 38 31 2478 0.62577 1.0 1.0 0.0 0 0 0 0 0 GO:1903312 8 negative regulation of mRNA metabolic process 13 14 1 1 1 0 0 0 38 14 2495 0.80978 1.0 1.0 0.0 0 0 0 0 0 GO:1903313 8 positive regulation of mRNA metabolic process 7 9 2 2 2 0 0 0 38 9 2500 0.87328 1.0 1.0 0.0 0 0 0 0 0 GO:1903363 8 negative regulation of cellular protein catabolic process 17 17 1 1 0 0 0 0 38 17 2492 0.77387 1.0 1.0 0.0 0 0 0 0 0 GO:1903429 7 regulation of cell maturation 18 19 2 2 1 1 0 0 38 19 2490 0.75079 1.0 1.0 0.0 0 0 0 0 0 GO:1903430 8 negative regulation of cell maturation 5 6 1 1 1 0 0 0 38 6 2503 0.91367 1.0 1.0 0.0 0 0 0 0 0 GO:1903431 8 positive regulation of cell maturation 11 11 1 1 0 1 0 0 38 11 2498 0.84732 1.0 1.0 0.0 0 0 0 0 0 GO:1903504 7 regulation of mitotic spindle checkpoint 3 3 1 1 1 0 0 0 38 3 2506 0.95589 1.0 1.0 0.0 0 0 0 0 0 GO:1903509 5 liposaccharide metabolic process 12 13 1 1 0 1 0 0 38 13 2496 0.82211 1.0 1.0 0.0 0 0 0 0 0 GO:1903510 7 mucopolysaccharide metabolic process 20 20 1 1 0 1 0 0 38 20 2489 0.73951 1.0 1.0 0.0 0 0 0 0 0 GO:1903530 5 regulation of secretion by cell 205 222 2 1 0 2 0 0 38 222 2287 0.030437 1.0 0.072871 0.0 0 0 0 0 0 GO:1903532 6 positive regulation of secretion by cell 132 141 1 0 0 1 0 0 38 141 2368 0.11299 1.0 0.26871 0.0 0 0 0 0 0 GO:1903538 6 regulation of meiotic cell cycle process involved in oocyte maturation 9 10 2 2 1 1 0 0 38 10 2499 0.8602 1.0 1.0 0.0 0 0 0 0 0 GO:1903556 7 negative regulation of tumor necrosis factor superfamily cytokine production 19 19 1 1 0 1 0 0 38 19 2490 0.75079 1.0 1.0 0.0 0 0 0 0 0 GO:1903578 5 regulation of ATP metabolic process 33 35 2 1 1 0 0 0 38 35 2474 0.58879 1.0 1.0 0.0 0 0 0 0 0 GO:1903579 6 negative regulation of ATP metabolic process 12 13 1 0 0 0 0 0 38 13 2496 0.82211 1.0 1.0 0.0 0 0 0 0 0 GO:1903580 6 positive regulation of ATP metabolic process 18 19 1 1 1 0 0 0 38 19 2490 0.75079 1.0 1.0 0.0 0 0 0 0 0 GO:1903707 6 negative regulation of hemopoiesis 45 48 1 1 1 0 0 0 38 48 2461 0.48272 1.0 1.0 0.0 0 0 0 0 0 GO:1903862 7 positive regulation of oxidative phosphorylation 4 4 1 1 1 0 0 0 38 4 2505 0.94161 1.0 1.0 0.0 0 0 0 0 0 GO:1904029 7 regulation of cyclin-dependent protein kinase activity 33 33 7 5 2 3 0 0 38 33 2476 0.607 1.0 1.0 0.0 0 0 0 0 0 GO:1904030 8 negative regulation of cyclin-dependent protein kinase activity 8 8 2 2 1 1 0 0 38 8 2501 0.88655 1.0 1.0 0.0 0 0 0 0 0 GO:1904031 8 positive regulation of cyclin-dependent protein kinase activity 18 18 4 3 2 1 0 0 38 18 2491 0.76224 1.0 1.0 0.0 0 0 0 0 0 GO:1904035 8 regulation of epithelial cell apoptotic process 41 44 1 1 1 0 0 0 38 44 2465 0.5132 1.0 1.0 0.0 0 0 0 0 0 GO:1904116 6 response to vasopressin 2 2 1 0 0 0 0 0 38 2 2507 0.97038 1.0 1.0 0.0 0 0 0 0 0 GO:1904117 7 cellular response to vasopressin 2 2 1 0 0 0 0 0 38 2 2507 0.97038 1.0 1.0 0.0 0 0 0 0 0 GO:1904145 7 negative regulation of meiotic cell cycle process involved in oocyte maturation 3 4 1 1 1 0 0 0 38 4 2505 0.94161 1.0 1.0 0.0 0 0 0 0 0 GO:1904146 7 positive regulation of meiotic cell cycle process involved in oocyte maturation 6 6 1 1 0 1 0 0 38 6 2503 0.91367 1.0 1.0 0.0 0 0 0 0 0 GO:1904245 6 regulation of polynucleotide adenylyltransferase activity 1 1 1 1 1 0 0 0 38 1 2508 0.98508 1.0 1.0 0.0 0 0 0 0 0 GO:1904246 7 negative regulation of polynucleotide adenylyltransferase activity 1 1 1 1 1 0 0 0 38 1 2508 0.98508 1.0 1.0 0.0 0 0 0 0 0 GO:1904375 7 regulation of protein localization to cell periphery 35 37 1 1 0 1 0 0 38 37 2472 0.57111 1.0 1.0 0.0 0 0 0 0 0 GO:1904385 7 cellular response to angiotensin 13 13 1 0 0 0 0 0 38 13 2496 0.82211 1.0 1.0 0.0 0 0 0 0 0 GO:1904580 6 regulation of intracellular mRNA localization 1 1 1 1 1 0 0 0 38 1 2508 0.98508 1.0 1.0 0.0 0 0 0 0 0 GO:1904582 6 positive regulation of intracellular mRNA localization 1 1 1 1 1 0 0 0 38 1 2508 0.98508 1.0 1.0 0.0 0 0 0 0 0 GO:1904666 9 regulation of ubiquitin protein ligase activity 6 6 2 2 0 2 0 0 38 6 2503 0.91367 1.0 1.0 0.0 0 0 0 0 0 GO:1904668 10 positive regulation of ubiquitin protein ligase activity 3 3 2 2 0 2 0 0 38 3 2506 0.95589 1.0 1.0 0.0 0 0 0 0 0 GO:1904705 7 regulation of vascular smooth muscle cell proliferation 30 31 2 2 1 1 0 0 38 31 2478 0.62577 1.0 1.0 0.0 0 0 0 0 0 GO:1904706 8 negative regulation of vascular smooth muscle cell proliferation 12 12 2 2 1 1 0 0 38 12 2497 0.83462 1.0 1.0 0.0 0 0 0 0 0 GO:1904776 8 regulation of protein localization to cell cortex 4 4 1 1 0 1 0 0 38 4 2505 0.94161 1.0 1.0 0.0 0 0 0 0 0 GO:1905132 7 regulation of meiotic chromosome separation 1 1 1 1 1 0 0 0 38 1 2508 0.98508 1.0 1.0 0.0 0 0 0 0 0 GO:1905133 8 negative regulation of meiotic chromosome separation 1 1 1 1 1 0 0 0 38 1 2508 0.98508 1.0 1.0 0.0 0 0 0 0 0 GO:1905178 6 regulation of cardiac muscle tissue regeneration 2 2 1 1 1 0 0 0 38 2 2507 0.97038 1.0 1.0 0.0 0 0 0 0 0 GO:1905179 7 negative regulation of cardiac muscle tissue regeneration 2 2 1 1 1 0 0 0 38 2 2507 0.97038 1.0 1.0 0.0 0 0 0 0 0 GO:1905269 9 positive regulation of chromatin organization 25 25 1 1 1 0 0 0 38 25 2484 0.68551 1.0 1.0 0.0 0 0 0 0 0 GO:1905359 9 protein localization to meiotic spindle 1 1 1 1 1 0 0 0 38 1 2508 0.98508 1.0 1.0 0.0 0 0 0 0 0 GO:1905446 7 regulation of mitochondrial ATP synthesis coupled electron transport 4 4 1 1 1 0 0 0 38 4 2505 0.94161 1.0 1.0 0.0 0 0 0 0 0 GO:1905448 8 positive regulation of mitochondrial ATP synthesis coupled electron transport 3 3 1 1 1 0 0 0 38 3 2506 0.95589 1.0 1.0 0.0 0 0 0 0 0 GO:1905784 11 regulation of anaphase-promoting complex-dependent catabolic process 1 1 1 1 0 1 0 0 38 1 2508 0.98508 1.0 1.0 0.0 0 0 0 0 0 GO:1905786 12 positive regulation of anaphase-promoting complex-dependent catabolic process 1 1 1 1 0 1 0 0 38 1 2508 0.98508 1.0 1.0 0.0 0 0 0 0 0 GO:1905818 6 regulation of chromosome separation 17 17 4 3 2 1 0 0 38 17 2492 0.77387 1.0 1.0 0.0 0 0 0 0 0 GO:1905819 7 negative regulation of chromosome separation 11 11 2 2 1 1 0 0 38 11 2498 0.84732 1.0 1.0 0.0 0 0 0 0 0 GO:1905879 5 regulation of oogenesis 12 13 2 2 1 1 0 0 38 13 2496 0.82211 1.0 1.0 0.0 0 0 0 0 0 GO:1905880 6 negative regulation of oogenesis 5 6 1 1 1 0 0 0 38 6 2503 0.91367 1.0 1.0 0.0 0 0 0 0 0 GO:1905881 6 positive regulation of oogenesis 7 7 1 1 0 1 0 0 38 7 2502 0.90001 1.0 1.0 0.0 0 0 0 0 0 GO:1990266 8 neutrophil migration 33 34 1 1 1 0 0 0 38 34 2475 0.59783 1.0 1.0 0.0 0 0 0 0 0 GO:1990314 7 cellular response to insulin-like growth factor stimulus 6 8 1 1 0 1 0 0 38 8 2501 0.88655 1.0 1.0 0.0 0 0 0 0 0 GO:1990705 5 cholangiocyte proliferation 1 1 1 1 0 1 0 0 38 1 2508 0.98508 1.0 1.0 0.0 0 0 0 0 0 GO:1990776 6 response to angiotensin 20 20 1 0 0 0 0 0 38 20 2489 0.73951 1.0 1.0 0.0 0 0 0 0 0 GO:1990928 5 response to amino acid starvation 14 16 1 1 1 0 0 0 38 16 2493 0.78566 1.0 1.0 0.0 0 0 0 0 0 GO:2000059 10 negative regulation of ubiquitin-dependent protein catabolic process 10 10 1 1 0 0 0 0 38 10 2499 0.8602 1.0 1.0 0.0 0 0 0 0 0 GO:2000116 8 regulation of cysteine-type endopeptidase activity 91 94 2 2 2 0 0 0 38 94 2415 0.23701 1.0 0.40015 0.0 0 0 0 0 0 GO:2000117 9 negative regulation of cysteine-type endopeptidase activity 43 44 1 1 1 0 0 0 38 44 2465 0.5132 1.0 1.0 0.0 0 0 0 0 0 GO:2000134 9 negative regulation of G1/S transition of mitotic cell cycle 18 18 1 1 1 0 0 0 38 18 2491 0.76224 1.0 1.0 0.0 0 0 0 0 0 GO:2000177 6 regulation of neural precursor cell proliferation 27 29 1 1 1 0 0 0 38 29 2480 0.64509 1.0 1.0 0.0 0 0 0 0 0 GO:2000243 5 positive regulation of reproductive process 28 28 1 1 0 1 0 0 38 28 2481 0.65498 1.0 1.0 0.0 0 0 0 0 0 GO:2000468 5 regulation of peroxidase activity 3 3 1 1 0 1 0 0 38 3 2506 0.95589 1.0 1.0 0.0 0 0 0 0 0 GO:2000469 6 negative regulation of peroxidase activity 1 1 1 1 0 1 0 0 38 1 2508 0.98508 1.0 1.0 0.0 0 0 0 0 0 GO:2000637 6 positive regulation of gene silencing by miRNA 9 10 1 1 1 0 0 0 38 10 2499 0.8602 1.0 1.0 0.0 0 0 0 0 0 GO:2000775 11 histone H3-S10 phosphorylation involved in chromosome condensation 1 1 1 1 1 0 0 0 38 1 2508 0.98508 1.0 1.0 0.0 0 0 0 0 0 GO:2000816 8 negative regulation of mitotic sister chromatid separation 11 11 2 2 1 1 0 0 38 11 2498 0.84732 1.0 1.0 0.0 0 0 0 0 0 GO:2001014 6 regulation of skeletal muscle cell differentiation 9 9 2 2 0 1 0 0 38 9 2500 0.87328 1.0 1.0 0.0 0 0 0 0 0 GO:2001016 7 positive regulation of skeletal muscle cell differentiation 4 4 1 1 0 0 0 0 38 4 2505 0.94161 1.0 1.0 0.0 0 0 0 0 0 GO:2001023 5 regulation of response to drug 39 43 1 1 0 1 0 0 38 43 2466 0.52111 1.0 1.0 0.0 0 0 0 0 0 GO:2001035 8 regulation of tongue muscle cell differentiation 1 1 1 1 0 0 0 0 38 1 2508 0.98508 1.0 1.0 0.0 0 0 0 0 0 GO:2001037 9 positive regulation of tongue muscle cell differentiation 1 1 1 1 0 0 0 0 38 1 2508 0.98508 1.0 1.0 0.0 0 0 0 0 0 GO:2001056 9 positive regulation of cysteine-type endopeptidase activity 48 51 1 1 1 0 0 0 38 51 2458 0.46102 1.0 1.0 0.0 0 0 0 0 0 GO:2001233 6 regulation of apoptotic signaling pathway 139 145 2 2 1 1 0 0 38 145 2364 0.10601 1.0 0.27329 0.0 0 0 0 0 0 GO:2001234 7 negative regulation of apoptotic signaling pathway 88 93 1 1 0 1 0 0 38 93 2416 0.24074 1.0 0.40024 0.0 0 0 0 0 0 GO:2001235 7 positive regulation of apoptotic signaling pathway 58 59 1 1 1 0 0 0 38 59 2450 0.4077 1.0 1.0 0.0 0 0 0 0 0 GO:2001236 7 regulation of extrinsic apoptotic signaling pathway 62 65 1 1 0 1 0 0 38 65 2444 0.3717 1.0 0.6245 0.0 0 0 0 0 0 GO:2001237 8 negative regulation of extrinsic apoptotic signaling pathway 46 48 1 1 0 1 0 0 38 48 2461 0.48272 1.0 1.0 0.0 0 0 0 0 0 GO:2001242 7 regulation of intrinsic apoptotic signaling pathway 62 64 1 1 1 0 0 0 38 64 2445 0.37748 1.0 1.0 0.0 0 0 0 0 0 GO:2001244 8 positive regulation of intrinsic apoptotic signaling pathway 24 24 1 1 1 0 0 0 38 24 2485 0.69599 1.0 1.0 0.0 0 0 0 0 0 GO:2001252 8 positive regulation of chromosome organization 43 43 1 1 1 0 0 0 38 43 2466 0.52111 1.0 1.0 0.0 0 0 0 0 0 GO:2001256 9 regulation of store-operated calcium entry 4 4 1 0 0 1 0 0 38 4 2505 0.94161 1.0 1.0 0.0 0 0 0 0 0 GO:0042592 4 homeostatic process 357 379 9 8 6 8 6 6 32 373 2136 0.66722 0.50696 0.81913 1.58 362246;25106;24314;24567;60628;25748 tp53inp2;rgn;nqo1;mt1;cxcr4;alas2 TP53INP2_32755;RGN_9699;NQO1_33055;MT1A_9255;CXCR4_8411;ALAS2_8019 309.10503333333355 116.98955 1.65461E-12 377.41083425689106 274.372172481969 357.3873160504531 186.1024833333336 70.41185 1.65461E-12 228.344555827078 164.4693477318741 215.77269675617555 985.8865333333337 671.297 1.65462E-12 1084.065850606404 919.0991342275087 1062.8805115498421 827.265;752.835;40.5511;168.588;1.65461E-12;65.3911 495.492;458.716;21.5832;103.554;1.65461E-12;37.2697 2498.6;1994.77;79.3552;1208.95;1.65462E-12;133.644 1 5 1 24314 NQO1_33055 40.5511 40.5511 21.5832 21.5832 79.3552 79.3552 40.5511 21.5832 79.3552 5 362246;25106;24567;60628;25748 TP53INP2_32755;RGN_9699;MT1A_9255;CXCR4_8411;ALAS2_8019 362.8158200000004 168.588 395.48995908298565 219.0063400000003 103.554 238.8651645662838 1167.1928000000003 1208.95 1105.6485621883648 827.265;752.835;168.588;1.65461E-12;65.3911 495.492;458.716;103.554;1.65461E-12;37.2697 2498.6;1994.77;1208.95;1.65462E-12;133.644 0 Exp 2,1(0.17);Exp 4,1(0.17);Exp 5,1(0.17);Hill,1(0.17);Linear,1(0.17);Poly 2,1(0.17) 1.872033334892574 11.394540667533875 1.5739303827285767 2.5798087120056152 0.3715162819052297 1.7296647429466248 7.113470673018014 611.0965959936492 3.388785209189507 368.8161814574777 118.45319402311054 1853.3198726435567 DOWN 0.16666666666666666 0.8333333333333334 0.0 GO:0008150 1 biological_process 2293 2547 88 81 57 56 38 38 0 2509 0 1.0 1.0 1.0 1.49 24522;360772;362246;360243;363328;89829;299276;25044;25106;363140;304951;338475;24314;316351;114519;24587;24567;291885;304477;315740;361308;499271;24450;60671;83928;361921;170568;266674;266684;29277;24296;60628;170945;24253;25612;25748;26760;54223 zfp354a;zfand2a;tp53inp2;top2a;ticam1;socs3;serpina3m;sds;rgn;rassf1;nuf2;nrep;nqo1;npas2;nfil3;nefh;mt1;mcm5;kntc1;kif23;kif20a;itgax;hmgcs2;gulo;fetub;ect2;dmbt1;cyp4a8;cyp2d1;cyp2c11;cyp1a1;cxcr4;chrna2;cebpb;asns;alas2;akr7a3;adcy4 ZFP354A_10203;ZFAND2A_10197;TP53INP2_32755;TOP2A_10059;TICAM1_10015;SOCS3_32863;SERPINA3M_9809;SDS_9798;RGN_9699;RASSF1_32475;NUF2_33136;NREP_9364;NQO1_33055;NPAS2_9350;NFIL3_9304;NEFH_33218;MT1A_9255;MCM5_9209;KNTC1_8976;KIF23_32798;KIF20A_8961;ITGAX_32980;HMGCS2_8812;GULO_8772;FETUB_33027;ECT2_8523;DMBT1_32993;CYP4A8_32747;CYP2D1_32660;CYP2C11_32593;CYP1A1_8415;CXCR4_8411;CHRNA2_32401;CEBPB_32843,CEBPB_8282;ASNS_8091;ALAS2_8019;AKR7A3_8015;ADCY4_7988 24253(-0.009836) 278.2963460526317 124.03399999999999 1.65461E-12 315.1265703022022 296.69628720082596 326.49090967378254 178.3798613157896 83.85239999999999 1.65461E-12 203.63166087268328 191.10369148441748 213.0628516985811 650.9398284210527 240.1845 1.65462E-12 768.6432820037339 665.8826105879458 763.6187993115592 99.2226;946.037;827.265;12.3342;811.122;809.124;466.86;553.681;752.835;903.848;9.55312;114.178;40.5511;155.028;121.321;2.95157E-12;168.588;12.5006;12.7573;10.3381;35.2747;148.304;106.351;193.989;545.901;31.2319;2.64673;76.6586;126.747;216.743;49.0449;1.65461E-12;592.031;620.8109999999999;157.765;65.3911;62.7952;716.432 71.0566;687.617;495.492;3.46407;489.389;488.627;296.126;377.484;458.716;608.514;4.27871;79.0815;21.5832;98.033;82.5516;2.95157E-12;103.554;9.67503;9.63387;4.23628;15.546;95.184;59.8697;112.274;382.164;16.4725;1.09657;57.8156;85.1532;139.563;39.2363;1.65461E-12;396.105;409.549;99.5663;37.2697;48.749;393.708 163.536;1292.08;2498.6;46.5267;2362.87;2346.74;918.743;1035.66;1994.77;1171.72;37.8054;204.229;79.3552;382.695;229.79;2.95158E-12;1208.95;36.0856;40.2833;21.7065;96.5441;340.985;208.329;1039.83;976.618;67.1945;8.73928;112.882;250.579;368.944;64.8529;1.65462E-12;1168.63;1279.85;371.219;133.644;87.647;2087.08 13 26 13 360772;89829;25044;363140;24314;60671;83928;170568;266674;266684;24296;25612;26760 ZFAND2A_10197;SOCS3_32863;SDS_9798;RASSF1_32475;NQO1_33055;GULO_8772;FETUB_33027;DMBT1_32993;CYP4A8_32747;CYP2D1_32660;CYP1A1_8415;ASNS_8091;AKR7A3_8015 343.7529638461538 157.765 356.77759365146005 231.52924384615386 99.5663 243.41777954961023 679.840183076923 371.219 700.0256168610623 946.037;809.124;553.681;903.848;40.5511;193.989;545.901;2.64673;76.6586;126.747;49.0449;157.765;62.7952 687.617;488.627;377.484;608.514;21.5832;112.274;382.164;1.09657;57.8156;85.1532;39.2363;99.5663;48.749 1292.08;2346.74;1035.66;1171.72;79.3552;1039.83;976.618;8.73928;112.882;250.579;64.8529;371.219;87.647 25 24522;362246;360243;363328;299276;25106;304951;338475;316351;114519;24587;24567;291885;304477;315740;361308;499271;24450;361921;29277;60628;170945;24253;25748;54223 ZFP354A_10203;TP53INP2_32755;TOP2A_10059;TICAM1_10015;SERPINA3M_9809;RGN_9699;NUF2_33136;NREP_9364;NPAS2_9350;NFIL3_9304;NEFH_33218;MT1A_9255;MCM5_9209;KNTC1_8976;KIF23_32798;KIF20A_8961;ITGAX_32980;HMGCS2_8812;ECT2_8523;CYP2C11_32593;CXCR4_8411;CHRNA2_32401;CEBPB_32843,CEBPB_8282;ALAS2_8019;ADCY4_7988 244.2589048000002 114.178 293.1246784476499 150.7421824000002 79.0815 178.81447741899424 635.9116440000001 208.329 815.5552246799169 99.2226;827.265;12.3342;811.122;466.86;752.835;9.55312;114.178;155.028;121.321;2.95157E-12;168.588;12.5006;12.7573;10.3381;35.2747;148.304;106.351;31.2319;216.743;1.65461E-12;592.031;620.8109999999999;65.3911;716.432 71.0566;495.492;3.46407;489.389;296.126;458.716;4.27871;79.0815;98.033;82.5516;2.95157E-12;103.554;9.67503;9.63387;4.23628;15.546;95.184;59.8697;16.4725;139.563;1.65461E-12;396.105;409.549;37.2697;393.708 163.536;2498.6;46.5267;2362.87;918.743;1994.77;37.8054;204.229;382.695;229.79;2.95158E-12;1208.95;36.0856;40.2833;21.7065;96.5441;340.985;208.329;67.1945;368.944;1.65462E-12;1168.63;1279.85;133.644;2087.08 0 Exp 2,5(0.13);Exp 4,5(0.13);Exp 5,5(0.13);Hill,3(0.08);Linear,7(0.18);Poly 2,14(0.36) 1.986520742217837 86.24666202068329 1.5054508447647095 8.822484970092773 1.5456382652411613 1.744480013847351 178.10059711447843 378.49209499078506 113.63436318438058 243.1253594471986 406.54663354450486 895.3330232976009 DOWN 0.34210526315789475 0.6578947368421053 0.0 GO:0044238 3 primary metabolic process 1157 1278 40 37 25 24 16 16 22 1262 1247 0.20084 0.87836 0.3316 1.25 362246;360243;89829;25044;25106;114519;291885;24450;60671;266674;266684;29277;24296;25612;25748;54223 tp53inp2;top2a;socs3;sds;rgn;nfil3;mcm5;hmgcs2;gulo;cyp4a8;cyp2d1;cyp2c11;cyp1a1;asns;alas2;adcy4 TP53INP2_32755;TOP2A_10059;SOCS3_32863;SDS_9798;RGN_9699;NFIL3_9304;MCM5_9209;HMGCS2_8812;GULO_8772;CYP4A8_32747;CYP2D1_32660;CYP2C11_32593;CYP1A1_8415;ASNS_8091;ALAS2_8019;ADCY4_7988 299.88640000000004 142.256 12.3342 311.0409290320509 288.60746995295915 315.1152615734536 183.77909375000002 92.35974999999999 3.46407 185.7986048015512 175.43176298142996 187.0592286824391 801.5957625 309.7615 36.0856 910.2871344943989 772.7688190367707 939.886979602325 827.265;12.3342;809.124;553.681;752.835;121.321;12.5006;106.351;193.989;76.6586;126.747;216.743;49.0449;157.765;65.3911;716.432 495.492;3.46407;488.627;377.484;458.716;82.5516;9.67503;59.8697;112.274;57.8156;85.1532;139.563;39.2363;99.5663;37.2697;393.708 2498.6;46.5267;2346.74;1035.66;1994.77;229.79;36.0856;208.329;1039.83;112.882;250.579;368.944;64.8529;371.219;133.644;2087.08 7 9 7 89829;25044;60671;266674;266684;24296;25612 SOCS3_32863;SDS_9798;GULO_8772;CYP4A8_32747;CYP2D1_32660;CYP1A1_8415;ASNS_8091 281.00135714285716 157.765 287.3384272505963 180.02234285714286 99.5663 177.50413393005675 745.9661285714285 371.219 814.791390790049 809.124;553.681;193.989;76.6586;126.747;49.0449;157.765 488.627;377.484;112.274;57.8156;85.1532;39.2363;99.5663 2346.74;1035.66;1039.83;112.882;250.579;64.8529;371.219 9 362246;360243;25106;114519;291885;24450;29277;25748;54223 TP53INP2_32755;TOP2A_10059;RGN_9699;NFIL3_9304;MCM5_9209;HMGCS2_8812;CYP2C11_32593;ALAS2_8019;ADCY4_7988 314.5747666666667 121.321 344.85113009161654 186.70101111111114 82.5516 202.66810527590567 844.8632555555555 229.79 1025.1535658476894 827.265;12.3342;752.835;121.321;12.5006;106.351;216.743;65.3911;716.432 495.492;3.46407;458.716;82.5516;9.67503;59.8697;139.563;37.2697;393.708 2498.6;46.5267;1994.77;229.79;36.0856;208.329;368.944;133.644;2087.08 0 Exp 2,3(0.19);Exp 4,1(0.07);Exp 5,2(0.13);Hill,1(0.07);Linear,3(0.19);Poly 2,6(0.38) 2.1831388581144537 42.799482464790344 1.5452189445495605 8.822484970092773 2.3407748505361954 1.7140328288078308 147.476344774295 452.29645522570485 92.7377773972399 274.8204101027601 355.55506659774454 1247.6364584022554 CONFLICT 0.4375 0.5625 0.0 GO:0048856 3 anatomical structure development 699 756 29 26 21 18 15 15 23 741 1768 0.93147 0.12576 0.20997 1.98 24522;360243;89829;25106;338475;24587;24450;361921;170568;266674;24296;60628;24253;25612;25748 zfp354a;top2a;socs3;rgn;nrep;nefh;hmgcs2;ect2;dmbt1;cyp4a8;cyp1a1;cxcr4;cebpb;asns;alas2 ZFP354A_10203;TOP2A_10059;SOCS3_32863;RGN_9699;NREP_9364;NEFH_33218;HMGCS2_8812;ECT2_8523;DMBT1_32993;CYP4A8_32747;CYP1A1_8415;CXCR4_8411;CEBPB_32843,CEBPB_8282;ASNS_8091;ALAS2_8019 24253(-0.009836) 193.17293533333364 76.6586 1.65461E-12 282.82835746128006 182.13295387648253 272.03845103981416 121.45472266666697 57.8156 1.65461E-12 174.64143108445188 113.81699096945728 167.11292136597794 466.8341586666669 133.644 1.65462E-12 762.8201073472251 444.49191207285077 754.6653375887449 99.2226;12.3342;809.124;752.835;114.178;2.95157E-12;106.351;31.2319;2.64673;76.6586;49.0449;1.65461E-12;620.8109999999999;157.765;65.3911 71.0566;3.46407;488.627;458.716;79.0815;2.95157E-12;59.8697;16.4725;1.09657;57.8156;39.2363;1.65461E-12;409.549;99.5663;37.2697 163.536;46.5267;2346.74;1994.77;204.229;2.95158E-12;208.329;67.1945;8.73928;112.882;64.8529;1.65462E-12;1279.85;371.219;133.644 5 11 5 89829;170568;266674;24296;25612 SOCS3_32863;DMBT1_32993;CYP4A8_32747;CYP1A1_8415;ASNS_8091 219.04784600000002 76.6586 334.64555755473 137.268354 57.8156 199.58714981315703 580.886636 112.882 996.8538475776359 809.124;2.64673;76.6586;49.0449;157.765 488.627;1.09657;57.8156;39.2363;99.5663 2346.74;8.73928;112.882;64.8529;371.219 10 24522;360243;25106;338475;24587;24450;361921;60628;24253;25748 ZFP354A_10203;TOP2A_10059;RGN_9699;NREP_9364;NEFH_33218;HMGCS2_8812;ECT2_8523;CXCR4_8411;CEBPB_32843,CEBPB_8282;ALAS2_8019 180.23548000000045 82.30685 272.2160881236152 113.54790700000046 48.5697 171.84591250930367 409.80792000000037 148.59 672.812760465749 99.2226;12.3342;752.835;114.178;2.95157E-12;106.351;31.2319;1.65461E-12;620.8109999999999;65.3911 71.0566;3.46407;458.716;79.0815;2.95157E-12;59.8697;16.4725;1.65461E-12;409.549;37.2697 163.536;46.5267;1994.77;204.229;2.95158E-12;208.329;67.1945;1.65462E-12;1279.85;133.644 0 Exp 2,1(0.07);Exp 4,3(0.19);Exp 5,1(0.07);Hill,3(0.19);Linear,3(0.19);Poly 2,5(0.32) 2.0552093543510135 37.3241251707077 1.5669527053833008 8.822484970092773 1.7746062072813522 1.72762531042099 50.04203827772284 336.30383238894444 33.07396439133974 209.8354809419942 80.79392127069406 852.8743960626398 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0010564 6 regulation of cell cycle process 146 156 18 16 11 9 5 5 33 151 2358 0.97414 0.079112 0.079112 3.21 363140;315740;361308;361921;24296 rassf1;kif23;kif20a;ect2;cyp1a1 RASSF1_32475;KIF23_32798;KIF20A_8961;ECT2_8523;CYP1A1_8415 205.94752 35.2747 10.3381 390.3848475218294 331.7966741286068 461.53802436480106 136.801016 16.4725 4.23628 264.00149288451814 224.30863454659644 310.14354992822257 284.4036 67.1945 21.7065 496.74280437438654 436.2942299780189 593.3930335627562 903.848;10.3381;35.2747;31.2319;49.0449 608.514;4.23628;15.546;16.4725;39.2363 1171.72;21.7065;96.5441;67.1945;64.8529 2 3 2 363140;24296 RASSF1_32475;CYP1A1_8415 476.44644999999997 476.44644999999997 604.4370685892825 323.87515 323.87515 402.5401220482811 618.2864500000001 618.2864500000001 782.6732322822884 903.848;49.0449 608.514;39.2363 1171.72;64.8529 3 315740;361308;361921 KIF23_32798;KIF20A_8961;ECT2_8523 25.614900000000002 31.2319 13.383628866641516 12.084926666666666 15.546 6.812895231554159 61.81503333333334 67.1945 37.70769934182318 10.3381;35.2747;31.2319 4.23628;15.546;16.4725 21.7065;96.5441;67.1945 0 Exp 4,2(0.4);Exp 5,1(0.2);Poly 2,2(0.4) 2.698483937322065 17.004106044769287 1.595955729484558 8.822484970092773 3.0577421643665486 2.1538212299346924 -136.2398861263227 548.1349261263226 -94.60649542647417 368.2085274264742 -151.01066574268316 719.8178657426832 DOWN 0.4 0.6 0.0 GO:0051960 6 regulation of nervous system development 221 237 5 5 4 5 4 4 34 233 2276 0.72405 0.47745 0.77601 1.69 338475;499271;361921;60628 nrep;itgax;ect2;cxcr4 NREP_9364;ITGAX_32980;ECT2_8523;CXCR4_8411 73.42847500000042 72.70495 1.65461E-12 69.37617245689678 108.98443743176522 59.09760692211516 47.68450000000041 47.777 1.65461E-12 46.51155624680761 71.79969009617905 38.77271163936979 153.10212500000043 135.71175 1.65462E-12 151.36524565675242 229.14803711983384 137.7477704208707 114.178;148.304;31.2319;1.65461E-12 79.0815;95.184;16.4725;1.65461E-12 204.229;340.985;67.1945;1.65462E-12 0 4 0 4 338475;499271;361921;60628 NREP_9364;ITGAX_32980;ECT2_8523;CXCR4_8411 73.42847500000042 72.70495 69.37617245689678 47.68450000000041 47.777 46.51155624680761 153.10212500000043 135.71175 151.36524565675242 114.178;148.304;31.2319;1.65461E-12 79.0815;95.184;16.4725;1.65461E-12 204.229;340.985;67.1945;1.65462E-12 0 Exp 4,1(0.25);Hill,1(0.25);Poly 2,2(0.5) 1.8507215792876177 7.437748074531555 1.6721540689468384 2.1538212299346924 0.2121428706924529 1.8058863878250122 5.439825992241538 141.41712400775927 2.1031748781289608 93.26582512187187 4.764184256383061 301.44006574361777 DOWN 0.0 1.0 0.0 GO:1901566 5 organonitrogen compound biosynthetic process 169 188 4 4 3 4 3 3 35 185 2324 0.69314 0.54043 0.75681 1.6 25612;25748;54223 asns;alas2;adcy4 ASNS_8091;ALAS2_8019;ADCY4_7988 313.19603333333333 157.765 65.3911 352.253698292159 299.26540087058135 353.34687728878345 176.84800000000004 99.5663 37.2697 190.37177126057847 168.56836768331874 191.5966300286825 863.9809999999999 371.219 133.644 1065.8746844760879 824.3869193105462 1067.014292448959 157.765;65.3911;716.432 99.5663;37.2697;393.708 371.219;133.644;2087.08 1 2 1 25612 ASNS_8091 157.765 157.765 99.5663 99.5663 371.219 371.219 157.765 99.5663 371.219 2 25748;54223 ALAS2_8019;ADCY4_7988 390.91155000000003 390.91155000000003 460.3554352197929 215.48885 215.48885 252.03993900460506 1110.362 1110.362 1381.2878422139243 65.3911;716.432 37.2697;393.708 133.644;2087.08 0 Exp 2,1(0.34);Exp 5,1(0.34);Poly 2,1(0.34) 1.6540351060274538 4.964052319526672 1.5997679233551025 1.7132161855697632 0.056810501470148544 1.6510682106018066 -85.41655102942428 711.808617696091 -38.57793903146566 392.2739390314657 -342.16975056916635 2070.1317505691663 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0032101 5 regulation of response to external stimulus 254 266 10 10 7 6 4 4 34 262 2247 0.63574 0.57229 1.0 1.5 363328;89829;60628;24253 ticam1;socs3;cxcr4;cebpb TICAM1_10015;SOCS3_32863;CXCR4_8411;CEBPB_32843,CEBPB_8282 24253(-0.009836) 560.2642500000004 714.9675 1.65461E-12 384.02375129183 653.1539297593774 321.2428414935961 346.8912500000004 449.08799999999997 1.65461E-12 234.27488451585305 401.69925058976196 193.6279848703927 1497.3650000000002 1813.2949999999998 1.65462E-12 1119.516489993187 1786.1709642604392 980.0721284829356 811.122;809.124;1.65461E-12;620.8109999999999 489.389;488.627;1.65461E-12;409.549 2362.87;2346.74;1.65462E-12;1279.85 1 4 1 89829 SOCS3_32863 809.124 809.124 488.627 488.627 2346.74 2346.74 809.124 488.627 2346.74 3 363328;60628;24253 TICAM1_10015;CXCR4_8411;CEBPB_32843,CEBPB_8282 477.31100000000055 620.8109999999999 424.17438892629895 299.6460000000006 409.549 262.5536143095339 1214.2400000000005 1279.85 1182.8005593928328 811.122;1.65461E-12;620.8109999999999 489.389;1.65461E-12;409.549 2362.87;1.65462E-12;1279.85 0 Hill,1(0.2);Linear,4(0.8) 1.6508274054640542 8.265164136886597 1.5415632724761963 1.744480013847351 0.0951078725205423 1.671766996383667 183.9209737340069 936.6075262659939 117.30186317446444 576.4806368255364 400.23883980667733 2594.491160193323 DOWN 0.25 0.75 0.0 GO:0019637 4 organophosphate metabolic process 156 173 4 4 3 4 3 3 35 170 2339 0.74429 0.48296 0.74096 1.73 89829;24450;54223 socs3;hmgcs2;adcy4 SOCS3_32863;HMGCS2_8812;ADCY4_7988 543.969 716.432 106.351 381.811585941286 481.19467623475833 402.9307911584897 314.06823333333335 393.708 59.8697 225.20007749080227 278.594648104569 237.83268431508418 1547.3829999999998 2087.08 208.329 1166.899755800386 1354.7241399155478 1231.1848014840623 809.124;106.351;716.432 488.627;59.8697;393.708 2346.74;208.329;2087.08 1 2 1 89829 SOCS3_32863 809.124 809.124 488.627 488.627 2346.74 2346.74 809.124 488.627 2346.74 2 24450;54223 HMGCS2_8812;ADCY4_7988 411.3915 411.3915 431.3924121730702 226.78885000000002 226.78885000000002 236.059325749789 1147.7045 1147.7045 1328.477572261007 106.351;716.432 59.8697;393.708 208.329;2087.08 0 Exp 2,1(0.34);Exp 4,1(0.34);Linear,1(0.34) 1.9495302137853523 5.970019221305847 1.6510682106018066 2.578549861907959 0.5116469897378962 1.7404011487960815 111.90851703107802 976.0294829689221 59.230355626088425 568.9061110405783 226.9116192678241 2867.8543807321757 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0043066 8 negative regulation of apoptotic process 279 296 10 10 8 8 6 6 32 290 2219 0.85582 0.27535 0.4393 2.03 89829;25106;24314;24567;24253;25612 socs3;rgn;nqo1;mt1;cebpb;asns SOCS3_32863;RGN_9699;NQO1_33055;MT1A_9255;CEBPB_32843,CEBPB_8282;ASNS_8091 24253(-0.009836) 424.94568333333336 394.69949999999994 40.5511 340.0975096352245 372.23630907408 347.8513268381933 263.59925 256.5515 21.5832 210.28667248142713 229.44806204079032 214.33415941772546 1213.4807 1244.4 79.3552 882.5826243013282 1124.8581390060963 933.7161120987881 809.124;752.835;40.5511;168.588;620.8109999999999;157.765 488.627;458.716;21.5832;103.554;409.549;99.5663 2346.74;1994.77;79.3552;1208.95;1279.85;371.219 3 4 3 89829;24314;25612 SOCS3_32863;NQO1_33055;ASNS_8091 335.8133666666667 157.765 414.06761683099944 203.25883333333334 99.5663 250.1930931928844 932.4380666666666 371.219 1233.4843284008164 809.124;40.5511;157.765 488.627;21.5832;99.5663 2346.74;79.3552;371.219 3 25106;24567;24253 RGN_9699;MT1A_9255;CEBPB_32843,CEBPB_8282 514.078 620.8109999999999 306.3985790094335 323.93966666666665 409.549 192.43630121765833 1494.5233333333333 1279.85 434.67430121107213 752.835;168.588;620.8109999999999 458.716;103.554;409.549 1994.77;1208.95;1279.85 0 Exp 2,1(0.15);Exp 4,1(0.15);Linear,3(0.43);Poly 2,2(0.29) 1.8223099725641745 12.941802859306335 1.5669527053833008 2.5798087120056152 0.36171426008948715 1.7148494720458984 152.81099861012194 697.0803680565447 95.33486788616128 431.86363211383866 507.26751877431036 1919.6938812256894 CONFLICT 0.5 0.5 0.0 GO:1903611 8 negative regulation of calcium-dependent ATPase activity 1 1 1 1 1 1 1 1 37 0 2509 1.0 0.01492 0.01492 100.0 25106 rgn RGN_9699 752.835 752.835 752.835 752.835 458.716 458.716 458.716 458.716 1994.77 1994.77 1994.77 1994.7699999999998 0.0 752.835 0.0 752.835 752.835 458.716 1994.77 0 1 0 1 25106 RGN_9699 752.835 752.835 458.716 458.716 1994.77 1994.77 752.835 458.716 1994.77 0 Exp 2,1(1) 1.7148494720458984 1.7148494720458984 1.7148494720458984 1.7148494720458984 0.0 1.7148494720458984 752.835 752.835 458.716 458.716 1994.77 1994.77 DOWN 0.0 1.0 0.0 GO:1903634 8 negative regulation of leucine-tRNA ligase activity 1 1 1 1 1 1 1 1 37 0 2509 1.0 0.01492 0.01492 100.0 25106 rgn RGN_9699 752.835 752.835 752.835 752.835 458.716 458.716 458.716 458.716 1994.77 1994.77 1994.77 1994.7699999999998 0.0 752.835 0.0 752.835 752.835 458.716 1994.77 0 1 0 1 25106 RGN_9699 752.835 752.835 458.716 458.716 1994.77 1994.77 752.835 458.716 1994.77 0 Exp 2,1(1) 1.7148494720458984 1.7148494720458984 1.7148494720458984 1.7148494720458984 0.0 1.7148494720458984 752.835 752.835 458.716 458.716 1994.77 1994.77 DOWN 0.0 1.0 0.0 GO:0072503 8 cellular divalent inorganic cation homeostasis 114 121 4 3 3 4 3 3 35 118 2391 0.8967 0.26894 0.42407 2.48 25106;24567;60628 rgn;mt1;cxcr4 RGN_9699;MT1A_9255;CXCR4_8411 307.1410000000006 168.588 1.65461E-12 395.07952954183736 272.4161537453023 339.71532379232565 187.4233333333339 103.554 1.65461E-12 240.58395825435457 166.44274993444665 206.78677801277243 1067.9066666666672 1208.95 1.65462E-12 1004.836680577163 1139.2148623372088 825.6264681016398 752.835;168.588;1.65461E-12 458.716;103.554;1.65461E-12 1994.77;1208.95;1.65462E-12 0 3 0 3 25106;24567;60628 RGN_9699;MT1A_9255;CXCR4_8411 307.1410000000006 168.588 395.07952954183736 187.4233333333339 103.554 240.58395825435457 1067.9066666666672 1208.95 1004.836680577163 752.835;168.588;1.65461E-12 458.716;103.554;1.65461E-12 1994.77;1208.95;1.65462E-12 0 Exp 2,1(0.34);Hill,1(0.34);Poly 2,1(0.34) 1.835828431409406 5.527585387229919 1.7148494720458984 2.06825590133667 0.19604629495393716 1.744480013847351 -139.93357455528889 754.21557455529 -84.82304426594646 459.6697109326142 -69.17308025808961 2204.986413591424 DOWN 0.0 1.0 0.0 GO:0051128 5 regulation of cellular component organization 515 547 18 16 11 11 6 6 32 541 1968 0.26148 0.85683 0.54966 1.1 360243;363328;89829;363140;361921;60628 top2a;ticam1;socs3;rassf1;ect2;cxcr4 TOP2A_10059;TICAM1_10015;SOCS3_32863;RASSF1_32475;ECT2_8523;CXCR4_8411 427.94335000000024 420.17795 1.65461E-12 454.2810259246832 580.1273738065777 434.56339909836856 267.74442833333364 252.54975000000002 1.65461E-12 289.38144248101094 369.3793744467601 282.95271389139555 999.1752000000002 619.45725 1.65462E-12 1138.4062873836297 1222.2461156170632 1046.059776891168 12.3342;811.122;809.124;903.848;31.2319;1.65461E-12 3.46407;489.389;488.627;608.514;16.4725;1.65461E-12 46.5267;2362.87;2346.74;1171.72;67.1945;1.65462E-12 2 4 2 89829;363140 SOCS3_32863;RASSF1_32475 856.486 856.486 66.9799827411141 548.5705 548.5705 84.7729106761117 1759.23 1759.23 830.8646100298168 809.124;903.848 488.627;608.514 2346.74;1171.72 4 360243;363328;361921;60628 TOP2A_10059;TICAM1_10015;ECT2_8523;CXCR4_8411 213.67202500000042 21.78305 398.5070161995673 127.33139250000042 9.968285 241.475880296051 619.1478000000004 56.860600000000005 1162.8210637015163 12.3342;811.122;31.2319;1.65461E-12 3.46407;489.389;16.4725;1.65461E-12 46.5267;2362.87;67.1945;1.65462E-12 0 Exp 4,1(0.17);Hill,2(0.34);Linear,2(0.34);Poly 2,1(0.17) 2.058785967404194 12.680545568466187 1.5415632724761963 2.846071243286133 0.5353769460913723 1.9491506218910217 64.44282364111365 791.4438763588869 36.191049131048345 499.297807535619 88.26045547174749 1910.0899445282532 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0071243 5 cellular response to arsenic-containing substance 6 6 1 1 1 1 1 1 37 5 2504 0.99687 0.086325 0.086325 16.67 360772 zfand2a ZFAND2A_10197 946.037 946.037 946.037 946.0369999999999 687.617 687.617 687.617 687.617 1292.08 1292.08 1292.08 1292.08 0.0 946.037 0.0 946.037 946.037 687.617 1292.08 1 0 1 360772 ZFAND2A_10197 946.037 946.037 687.617 687.617 1292.08 1292.08 946.037 687.617 1292.08 0 0 Poly 2,1(1) 2.554074764251709 2.554074764251709 2.554074764251709 2.554074764251709 0.0 2.554074764251709 946.037 946.037 687.617 687.617 1292.08 1292.08 UP 1.0 0.0 0.0 GO:0007623 3 circadian rhythm 58 63 3 3 2 3 2 2 36 61 2448 0.93411 0.24161 0.24161 3.17 316351;114519 npas2;nfil3 NPAS2_9350;NFIL3_9304 138.1745 138.1745 121.321 23.83444827345492 137.70951402295353 23.825375140431753 90.2923 90.2923 82.5516 10.947002922261353 90.07873504598312 10.94283569285536 306.2425 306.2425 229.79 108.12016237732898 304.13318499657976 108.0790039412499 155.028;121.321 98.033;82.5516 382.695;229.79 0 2 0 2 316351;114519 NPAS2_9350;NFIL3_9304 138.1745 138.1745 23.83444827345492 90.2923 90.2923 10.947002922261353 306.2425 306.2425 108.12016237732898 155.028;121.321 98.033;82.5516 382.695;229.79 0 Poly 2,2(1) 1.8368090207488028 3.7215163707733154 1.563178539276123 2.1583378314971924 0.42084117141570415 1.8607581853866577 105.14164 171.20736 75.120528 105.464072 156.3956 456.0894 DOWN 0.0 1.0 0.0 GO:0048468 4 cell development 159 163 7 7 6 3 2 2 36 161 2348 0.55697 0.71076 1.0 1.23 60628;25748 cxcr4;alas2 CXCR4_8411;ALAS2_8019 32.69555000000082 32.69555000000082 1.65461E-12 46.23849023924648 48.293234123070754 40.637697764498874 18.634850000000828 18.634850000000828 1.65461E-12 26.3536576027871 27.52476021655275 23.161482286939876 66.82200000000083 66.82200000000083 1.65462E-12 94.5005786648938 98.69999099485463 83.0538785865165 1.65461E-12;65.3911 1.65461E-12;37.2697 1.65462E-12;133.644 0 2 0 2 60628;25748 CXCR4_8411;ALAS2_8019 32.69555000000082 32.69555000000082 46.23849023924648 18.634850000000828 18.634850000000828 26.3536576027871 66.82200000000083 66.82200000000083 94.5005786648938 1.65461E-12;65.3911 1.65461E-12;37.2697 1.65462E-12;133.644 0 Exp 5,1(0.5);Hill,1(0.5) 1.7287774278738852 3.4576961994171143 1.7132161855697632 1.744480013847351 0.022106864980934136 1.7288480997085571 -31.387727999997544 96.77882799999921 -17.889455999997548 55.1591559999992 -64.14911999999754 197.7931199999992 DOWN 0.0 1.0 0.0 GO:0035711 8 T-helper 1 cell activation 1 1 1 1 1 1 1 1 37 0 2509 1.0 0.01492 0.01492 100.0 24253 cebpb CEBPB_32843,CEBPB_8282 24253(-0.009836) 620.8109999999999 620.8109999999999 620.8109999999999 620.8109999999999 409.549 409.549 409.549 409.54900000000004 1279.85 1279.85 1279.85 1279.85 0.0 620.8109999999999 0.0 620.8109999999999 620.8109999999999 409.549 1279.85 0 2 0 1 24253 CEBPB_32843,CEBPB_8282 620.8109999999999 620.8109999999999 409.549 409.549 1279.85 1279.85 620.8109999999999 409.549 1279.85 0 Linear,2(1) 1.61851160569021 3.2387197017669678 1.5669527053833008 1.671766996383667 0.07411489593161907 1.6193598508834839 620.8109999999999 620.8109999999999 409.549 409.549 1279.85 1279.85 DOWN 0.0 1.0 0.0 GO:0043152 6 induction of bacterial agglutination 3 3 1 1 1 1 1 1 37 2 2507 0.99936 0.044111 0.044111 33.33 170568 dmbt1 DMBT1_32993 2.64673 2.64673 2.64673 2.64673 1.09657 1.09657 1.09657 1.09657 8.73928 8.73928 8.73928 8.73928 0.0 2.64673 0.0 2.64673 2.64673 1.09657 8.73928 1 0 1 170568 DMBT1_32993 2.64673 2.64673 1.09657 1.09657 8.73928 8.73928 2.64673 1.09657 8.73928 0 0 Exp 4,1(1) 1.6491305828094482 1.6491305828094482 1.6491305828094482 1.6491305828094482 0.0 1.6491305828094482 2.64673 2.64673 1.09657 1.09657 8.73928 8.73928 UP 1.0 0.0 0.0 GO:0040007 2 growth 94 98 4 4 4 2 2 2 36 96 2413 0.82207 0.43358 0.65624 2.04 361308;170568 kif20a;dmbt1 KIF20A_8961;DMBT1_32993 18.960715 18.960715 2.64673 23.07145884335124 8.62618725286533 17.851814631791843 8.321285 8.321285 1.09657 10.217289937280336 3.7445971072110793 7.905749143910944 52.64169 52.64169 8.73928 62.08738364286419 24.830540589780327 48.04084870795972 35.2747;2.64673 15.546;1.09657 96.5441;8.73928 1 1 1 170568 DMBT1_32993 2.64673 2.64673 1.09657 1.09657 8.73928 8.73928 2.64673 1.09657 8.73928 1 361308 KIF20A_8961 35.2747 35.2747 15.546 15.546 96.5441 96.5441 35.2747 15.546 96.5441 0 Exp 4,2(1) 1.7121778512011538 3.426766037940979 1.6491305828094482 1.7776354551315308 0.09086666663445603 1.7133830189704895 -13.014695600000003 50.936125600000004 -5.8391563999999985 22.4817264 -33.407033600000005 138.6904136 CONFLICT 0.5 0.5 0.0 GO:0045321 3 leukocyte activation 139 149 4 4 4 4 4 4 34 145 2364 0.9324 0.17914 0.2786 2.68 363328;499271;60628;24253 ticam1;itgax;cxcr4;cebpb TICAM1_10015;ITGAX_32980;CXCR4_8411;CEBPB_32843,CEBPB_8282 24253(-0.009836) 395.05925000000036 384.55749999999995 1.65461E-12 383.4197130120589 373.64234189702483 359.4973056055828 248.53050000000042 252.36649999999997 1.65461E-12 237.50251427230486 234.65580412534314 221.3306780235404 995.9262500000004 810.4175 1.65462E-12 1059.8687100876764 946.9790525427308 1011.9239240921842 811.122;148.304;1.65461E-12;620.8109999999999 489.389;95.184;1.65461E-12;409.549 2362.87;340.985;1.65462E-12;1279.85 0 5 0 4 363328;499271;60628;24253 TICAM1_10015;ITGAX_32980;CXCR4_8411;CEBPB_32843,CEBPB_8282 395.05925000000036 384.55749999999995 383.4197130120589 248.53050000000042 252.36649999999997 237.50251427230486 995.9262500000004 810.4175 1059.8687100876764 811.122;148.304;1.65461E-12;620.8109999999999 489.389;95.184;1.65461E-12;409.549 2362.87;340.985;1.65462E-12;1279.85 0 Hill,1(0.2);Linear,3(0.6);Poly 2,1(0.2) 1.6742267650443763 8.392055749893188 1.5415632724761963 1.8672927618026733 0.13345020539856506 1.671766996383667 19.30793124818274 770.810568751818 15.778036013141616 481.2829639868592 -42.74508588592266 2034.5975858859235 DOWN 0.0 1.0 0.0 GO:0060548 6 negative regulation of cell death 321 341 11 11 9 9 7 7 31 334 2175 0.87427 0.23913 0.3379 2.05 89829;25106;24314;316351;24567;24253;25612 socs3;rgn;nqo1;npas2;mt1;cebpb;asns SOCS3_32863;RGN_9699;NQO1_33055;NPAS2_9350;MT1A_9255;CEBPB_32843,CEBPB_8282;ASNS_8091 24253(-0.009836) 386.3860142857143 168.588 40.5511 326.79738869239475 335.4073875 324.72042124946177 239.94692857142854 103.554 21.5832 201.9069835728383 207.16588032230703 199.81784993207975 1094.7970285714287 1208.95 79.3552 864.7123438723454 999.0200982877437 891.2770817595808 809.124;752.835;40.5511;155.028;168.588;620.8109999999999;157.765 488.627;458.716;21.5832;98.033;103.554;409.549;99.5663 2346.74;1994.77;79.3552;382.695;1208.95;1279.85;371.219 3 5 3 89829;24314;25612 SOCS3_32863;NQO1_33055;ASNS_8091 335.8133666666667 157.765 414.06761683099944 203.25883333333334 99.5663 250.1930931928844 932.4380666666666 371.219 1233.4843284008164 809.124;40.5511;157.765 488.627;21.5832;99.5663 2346.74;79.3552;371.219 4 25106;316351;24567;24253 RGN_9699;NPAS2_9350;MT1A_9255;CEBPB_32843,CEBPB_8282 424.3155 394.69949999999994 307.9219897490272 267.46299999999997 256.5515 193.51040160329032 1216.5662499999999 1244.4 659.5466064827544 752.835;155.028;168.588;620.8109999999999 458.716;98.033;103.554;409.549 1994.77;382.695;1208.95;1279.85 0 Exp 2,1(0.13);Exp 4,1(0.13);Linear,3(0.38);Poly 2,3(0.38) 1.7877037179858375 14.504981398582458 1.563178539276123 2.5798087120056152 0.34977949955507714 1.6933082342147827 144.2911208018057 628.4809077696228 90.37214195116724 389.52171519169 454.20915967311043 1735.3848974697469 CONFLICT 0.42857142857142855 0.5714285714285714 0.0 GO:0001666 4 response to hypoxia 168 175 8 7 6 6 5 5 33 170 2339 0.95768 0.1154 0.18091 2.86 24522;89829;24296;60628;25748 zfp354a;socs3;cyp1a1;cxcr4;alas2 ZFP354A_10203;SOCS3_32863;CYP1A1_8415;CXCR4_8411;ALAS2_8019 204.55652000000035 65.3911 1.65461E-12 339.8497169814282 226.69571966885343 354.40071597250596 127.23792000000033 39.2363 1.65461E-12 203.58441853363166 140.79243664363156 211.8196079034874 541.7545800000003 133.644 1.65462E-12 1011.0031087384854 604.9778143578772 1058.3925862599638 99.2226;809.124;49.0449;1.65461E-12;65.3911 71.0566;488.627;39.2363;1.65461E-12;37.2697 163.536;2346.74;64.8529;1.65462E-12;133.644 2 3 2 89829;24296 SOCS3_32863;CYP1A1_8415 429.08445 429.08445 537.457085848168 263.93165 263.93165 317.76721137216947 1205.7964499999998 1205.7964499999998 1613.5378423121053 809.124;49.0449 488.627;39.2363 2346.74;64.8529 3 24522;60628;25748 ZFP354A_10203;CXCR4_8411;ALAS2_8019 54.87123333333388 65.3911 50.4408741369858 36.108766666667215 37.2697 35.54252277966878 99.06000000000056 133.644 87.08068451729027 99.2226;1.65461E-12;65.3911 71.0566;1.65461E-12;37.2697 163.536;1.65462E-12;133.644 0 Exp 5,1(0.2);Hill,1(0.2);Linear,1(0.2);Poly 2,2(0.4) 2.426628046346161 15.854152798652649 1.7132161855697632 8.822484970092773 3.159695631593663 1.744480013847351 -93.3348911673786 502.44793116737924 -51.211690808379245 305.68753080837996 -344.4287172283226 1427.937877228323 DOWN 0.4 0.6 0.0 GO:0006778 5 porphyrin-containing compound metabolic process 14 15 2 2 2 2 2 2 36 13 2496 0.99877 0.020141 0.020141 13.33 24296;25748 cyp1a1;alas2 CYP1A1_8415;ALAS2_8019 57.217999999999996 57.217999999999996 49.0449 11.558508866631579 55.7398448156956 11.367904016230389 38.253 38.253 37.2697 1.3905961958815285 38.43083582639715 1.3676646583498602 99.24845 99.24845 64.8529 48.6426532952819 93.02780415576694 47.84051473559053 0.0 49.0449 0.5 57.217999999999996 49.0449;65.3911 39.2363;37.2697 64.8529;133.644 1 1 1 24296 CYP1A1_8415 49.0449 49.0449 39.2363 39.2363 64.8529 64.8529 49.0449 39.2363 64.8529 1 25748 ALAS2_8019 65.3911 65.3911 37.2697 37.2697 133.644 133.644 65.3911 37.2697 133.644 0 Exp 5,1(0.5);Poly 2,1(0.5) 3.887778806427766 10.535701155662537 1.7132161855697632 8.822484970092773 5.027012166814065 5.267850577831268 41.198724 73.237276 36.325732 40.180268 31.833172000000005 166.663728 CONFLICT 0.5 0.5 0.0 GO:0071157 7 negative regulation of cell cycle arrest 7 8 1 1 1 1 1 1 37 7 2502 0.99426 0.11345 0.11345 12.5 363140 rassf1 RASSF1_32475 903.848 903.848 903.848 903.848 608.514 608.514 608.514 608.514 1171.72 1171.72 1171.72 1171.72 0.0 903.848 0.0 903.848 903.848 608.514 1171.72 1 0 1 363140 RASSF1_32475 903.848 903.848 608.514 608.514 1171.72 1171.72 903.848 608.514 1171.72 0 0 Poly 2,1(1) 2.6542086601257324 2.6542086601257324 2.6542086601257324 2.6542086601257324 0.0 2.6542086601257324 903.848 903.848 608.514 608.514 1171.72 1171.72 UP 1.0 0.0 0.0 GO:0042127 5 regulation of cell population proliferation 436 466 15 13 9 9 4 4 34 462 2047 0.14845 0.93686 0.28989 0.86 363328;25106;499271;24253 ticam1;rgn;itgax;cebpb TICAM1_10015;RGN_9699;ITGAX_32980;CEBPB_32843,CEBPB_8282 24253(-0.009836) 583.2679999999999 686.823 148.304 300.70670702530094 474.8765777500779 342.41283587940654 363.2095 434.1325 95.184 181.68450279995452 296.2314903396697 208.29966314498213 1494.61875 1637.31 340.985 890.8812025402617 1215.8834740833074 984.0476838411853 811.122;752.835;148.304;620.8109999999999 489.389;458.716;95.184;409.549 2362.87;1994.77;340.985;1279.85 0 5 0 4 363328;25106;499271;24253 TICAM1_10015;RGN_9699;ITGAX_32980;CEBPB_32843,CEBPB_8282 583.2679999999999 686.823 300.70670702530094 363.2095 434.1325 181.68450279995452 1494.61875 1637.31 890.8812025402617 811.122;752.835;148.304;620.8109999999999 489.389;458.716;95.184;409.549 2362.87;1994.77;340.985;1279.85 0 Exp 2,1(0.2);Linear,3(0.6);Poly 2,1(0.2) 1.6685002715704624 8.362425208091736 1.5415632724761963 1.8672927618026733 0.13040599298379862 1.671766996383667 288.57542711520534 877.9605728847945 185.15868725604457 541.2603127439554 621.5551715105431 2367.6823284894563 DOWN 0.0 1.0 0.0 GO:0006810 4 transport 570 605 9 9 7 5 4 4 34 601 1908 0.033526 0.9892 0.055229 0.66 315740;170568;170945;25748 kif23;dmbt1;chrna2;alas2 KIF23_32798;DMBT1_32993;CHRNA2_32401;ALAS2_8019 167.6017325 37.864599999999996 2.64673 284.32916339078236 63.29164418097537 163.3720644530197 109.6768875 20.75299 1.09657 191.6518297071912 39.24907691736438 109.74665709101905 333.17994500000003 77.67525 8.73928 559.7823504995362 127.93068125821866 321.7915030938845 10.3381;2.64673;592.031;65.3911 4.23628;1.09657;396.105;37.2697 21.7065;8.73928;1168.63;133.644 1 3 1 170568 DMBT1_32993 2.64673 2.64673 1.09657 1.09657 8.73928 8.73928 2.64673 1.09657 8.73928 3 315740;170945;25748 KIF23_32798;CHRNA2_32401;ALAS2_8019 222.5867333333333 65.3911 321.1300481610267 145.87032666666667 37.2697 217.33809034061224 441.32683333333335 133.644 632.3447818706843 10.3381;592.031;65.3911 4.23628;396.105;37.2697 21.7065;1168.63;133.644 0 Exp 4,1(0.25);Exp 5,2(0.5);Linear,1(0.25) 1.704770816436769 6.831467151641846 1.595955729484558 1.8731646537780762 0.1201749104477574 1.6811733841896057 -111.04084762296674 446.2443126229667 -78.14190561304736 297.4956806130474 -215.40675848954533 881.7666484895453 DOWN 0.25 0.75 0.0 GO:0010038 5 response to metal ion 201 215 9 9 8 7 6 6 32 209 2300 0.96349 0.095525 0.12968 2.79 24314;24567;24450;361921;24296;25748 nqo1;mt1;hmgcs2;ect2;cyp1a1;alas2 NQO1_33055;MT1A_9255;HMGCS2_8812;ECT2_8523;CYP1A1_8415;ALAS2_8019 76.85966666666667 57.217999999999996 31.2319 52.132945914025086 80.65381192763446 48.76727729895699 46.33090000000001 38.253 16.4725 31.919253373160206 49.353737696884 28.952082077744215 293.72093333333333 106.4996 64.8529 451.7096679601784 285.7707538425903 433.42751799996597 40.5511;168.588;106.351;31.2319;49.0449;65.3911 21.5832;103.554;59.8697;16.4725;39.2363;37.2697 79.3552;1208.95;208.329;67.1945;64.8529;133.644 2 4 2 24314;24296 NQO1_33055;CYP1A1_8415 44.798 44.798 6.006023578042245 30.409750000000003 30.409750000000003 12.482626718964237 72.10405 72.10405 10.254674672801642 40.5511;49.0449 21.5832;39.2363 79.3552;64.8529 4 24567;24450;361921;25748 MT1A_9255;HMGCS2_8812;ECT2_8523;ALAS2_8019 92.8905 85.87105 59.07423725229128 54.291475 48.5697 37.3181307933445 404.529375 170.9865 539.3702603826329 168.588;106.351;31.2319;65.3911 103.554;59.8697;16.4725;37.2697 1208.95;208.329;67.1945;133.644 0 Exp 4,3(0.5);Exp 5,1(0.17);Poly 2,2(0.34) 2.7660711269696265 19.916136860847473 1.7132161855697632 8.822484970092773 2.7160103183711763 2.3661855459213257 35.14462201602494 118.5747113173084 20.790177979947916 71.87162202005209 -67.72207813892112 655.1639448055878 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0072383 7 plus-end-directed vesicle transport along microtubule 1 1 1 1 1 1 1 1 37 0 2509 1.0 0.01492 0.01492 100.0 315740 kif23 KIF23_32798 10.3381 10.3381 10.3381 10.3381 4.23628 4.23628 4.23628 4.23628 21.7065 21.7065 21.7065 21.7065 0.0 10.3381 0.0 10.3381 10.3381 4.23628 21.7065 0 1 0 1 315740 KIF23_32798 10.3381 10.3381 4.23628 4.23628 21.7065 21.7065 10.3381 4.23628 21.7065 0 Exp 5,1(1) 1.595955729484558 1.595955729484558 1.595955729484558 1.595955729484558 0.0 1.595955729484558 10.3381 10.3381 4.23628 4.23628 21.7065 21.7065 DOWN 0.0 1.0 0.0 GO:0008037 3 cell recognition 38 40 2 2 2 2 2 2 36 38 2471 0.9793 0.11873 0.11873 5.0 83928;60628 fetub;cxcr4 FETUB_33027;CXCR4_8411 272.95050000000083 272.95050000000083 1.65461E-12 386.01029895651624 395.18189891329 345.1418855194191 191.08200000000082 191.08200000000082 1.65461E-12 270.2307559253746 276.6514353633692 241.62037354326728 488.3090000000009 488.3090000000009 1.65462E-12 690.5732104288425 706.981221417252 617.4595356158069 1.0 545.901 545.901;1.65461E-12 382.164;1.65461E-12 976.618;1.65462E-12 1 1 1 83928 FETUB_33027 545.901 545.901 382.164 382.164 976.618 976.618 545.901 382.164 976.618 1 60628 CXCR4_8411 1.65461E-12 1.65461E-12 1.65461E-12 1.65461E-12 1.65462E-12 1.65462E-12 1.65461E-12 1.65461E-12 1.65462E-12 0 Exp 2,1(0.5);Hill,1(0.5) 1.6205643802458596 3.2499308586120605 1.5054508447647095 1.744480013847351 0.16901914635972173 1.6249654293060303 -262.03247999999735 807.933479999999 -183.43871999999757 565.6027199999992 -468.7766399999974 1445.394639999999 CONFLICT 0.5 0.5 0.0 GO:0008285 6 negative regulation of cell population proliferation 190 199 4 4 3 3 2 2 36 197 2312 0.41965 0.81041 0.76486 1.01 25106;24253 rgn;cebpb RGN_9699;CEBPB_32843,CEBPB_8282 24253(-0.009836) 686.823 686.823 620.8109999999999 93.35506567937298 677.7343913043478 92.46600819736358 434.1325 434.1325 409.549 34.76631911059856 430.74781521739135 34.4352256032197 1637.31 1637.31 1279.85 505.5247800058865 1588.0944927536232 500.7104661308404 752.835;620.8109999999999 458.716;409.549 1994.77;1279.85 0 3 0 2 25106;24253 RGN_9699;CEBPB_32843,CEBPB_8282 686.823 686.823 93.35506567937298 434.1325 434.1325 34.76631911059856 1637.31 1637.31 505.5247800058865 752.835;620.8109999999999 458.716;409.549 1994.77;1279.85 0 Exp 2,1(0.34);Linear,2(0.67) 1.6500073544156273 4.953569173812866 1.5669527053833008 1.7148494720458984 0.07606531063976872 1.671766996383667 557.4394799999999 816.2065200000001 385.94883999999996 482.31616 936.6884 2337.9316 DOWN 0.0 1.0 0.0 GO:0019373 7 epoxygenase P450 pathway 10 13 1 1 1 1 1 1 37 12 2497 0.98475 0.17789 0.17789 7.69 29277 cyp2c11 CYP2C11_32593 216.743 216.743 216.743 216.743 139.563 139.563 139.563 139.563 368.944 368.944 368.944 368.944 0.0 216.743 216.743 139.563 368.944 0 1 0 1 29277 CYP2C11_32593 216.743 216.743 139.563 139.563 368.944 368.944 216.743 139.563 368.944 0 Exp 2,1(1) 8.3532075881958 8.3532075881958 8.3532075881958 8.3532075881958 0.0 8.3532075881958 216.743 216.743 139.563 139.563 368.944 368.944 DOWN 0.0 1.0 0.0 GO:0032870 5 cellular response to hormone stimulus 198 212 10 7 5 6 3 3 35 209 2300 0.60916 0.62481 1.0 1.42 24587;24450;25612 nefh;hmgcs2;asns NEFH_33218;HMGCS2_8812;ASNS_8091 88.03866666666765 106.351 2.95157E-12 80.46089093673443 103.73421502715799 62.42168359598982 53.145333333334314 59.8697 2.95157E-12 50.12259823894983 61.480484834037895 39.391556579922465 193.18266666666764 208.329 2.95158E-12 186.07241883291775 221.03408961979528 147.64612071823765 2.95157E-12;106.351;157.765 2.95157E-12;59.8697;99.5663 2.95158E-12;208.329;371.219 1 2 1 25612 ASNS_8091 157.765 157.765 99.5663 99.5663 371.219 371.219 157.765 99.5663 371.219 2 24587;24450 NEFH_33218;HMGCS2_8812 53.17550000000148 53.17550000000148 75.20151328596843 29.934850000001475 29.934850000001475 42.33427085760216 104.16450000000148 104.16450000000148 147.31084861781017 2.95157E-12;106.351 2.95157E-12;59.8697 2.95158E-12;208.329 0 Exp 4,1(0.34);Hill,1(0.34);Poly 2,1(0.34) 2.1602874214297283 6.6223227977752686 1.5997679233551025 2.578549861907959 0.5305425937102308 2.444005012512207 -3.0114027347914174 179.0887360681267 -3.573726014718325 109.86439268138696 -17.378097093154054 403.74343042648934 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0018130 5 heterocycle biosynthetic process 162 180 4 4 4 3 3 3 35 177 2332 0.72064 0.51018 0.748 1.67 114519;25748;54223 nfil3;alas2;adcy4 NFIL3_9304;ALAS2_8019;ADCY4_7988 301.0480333333333 121.321 65.3911 360.81840065509874 271.524238660252 346.28917616953936 171.17643333333334 82.5516 37.2697 194.0433875174399 155.30813006850389 186.3851026479429 816.8380000000001 229.79 133.644 1101.1117414922064 726.8069777754536 1056.22338853438 121.321;65.3911;716.432 82.5516;37.2697;393.708 229.79;133.644;2087.08 0 3 0 3 114519;25748;54223 NFIL3_9304;ALAS2_8019;ADCY4_7988 301.0480333333333 121.321 360.81840065509874 171.17643333333334 82.5516 194.0433875174399 816.8380000000001 229.79 1101.1117414922064 121.321;65.3911;716.432 82.5516;37.2697;393.708 229.79;133.644;2087.08 0 Exp 2,1(0.34);Exp 5,1(0.34);Poly 2,1(0.34) 1.8276745700198063 5.522622227668762 1.6510682106018066 2.1583378314971924 0.2766821638478315 1.7132161855697632 -107.25642413037798 709.3524907970448 -48.40433062128179 390.75719728794843 -429.18723430243085 2062.863234302431 DOWN 0.0 1.0 0.0 GO:0051301 3 cell division 78 79 14 12 6 8 4 4 34 75 2434 0.99431 0.028442 0.028442 5.06 360243;304951;291885;361308 top2a;nuf2;mcm5;kif20a TOP2A_10059;NUF2_33136;MCM5_9209;KIF20A_8961 17.415655 12.4174 9.55312 11.982541404174938 15.088777879261231 9.524066523080016 8.240952499999999 6.97687 3.46407 5.595780234571852 5.986081797298539 4.969161241880663 54.240449999999996 42.16605 36.0856 28.570440373516586 50.88715533400716 21.88715655579656 2.5 23.88765 12.3342;9.55312;12.5006;35.2747 3.46407;4.27871;9.67503;15.546 46.5267;37.8054;36.0856;96.5441 0 4 0 4 360243;304951;291885;361308 TOP2A_10059;NUF2_33136;MCM5_9209;KIF20A_8961 17.415655 12.4174 11.982541404174938 8.240952499999999 6.97687 5.595780234571852 54.240449999999996 42.16605 28.570440373516586 12.3342;9.55312;12.5006;35.2747 3.46407;4.27871;9.67503;15.546 46.5267;37.8054;36.0856;96.5441 0 Exp 4,1(0.25);Exp 5,2(0.5);Hill,1(0.25) 2.035585640543502 8.310512781143188 1.7765510082244873 2.846071243286133 0.5161271149291591 1.8439452648162842 5.672764423908562 29.15854557609144 2.7570878701195856 13.724817129880412 26.24141843395374 82.23948156604625 DOWN 0.0 1.0 0.0 GO:1903047 4 mitotic cell cycle process 136 146 23 21 13 13 6 6 32 140 2369 0.99505 0.01926 0.01926 4.11 360243;304951;304477;315740;361308;361921 top2a;nuf2;kntc1;kif23;kif20a;ect2 TOP2A_10059;NUF2_33136;KNTC1_8976;KIF23_32798;KIF20A_8961;ECT2_8523 18.581553333333332 12.54575 9.55312 11.498790356357787 14.332599307401214 8.078042966654719 8.938571666666666 6.95629 3.46407 5.9109669471835735 6.851674081228549 4.648981108301861 51.67675 43.405 21.7065 26.460701483048393 42.22165132007392 20.662202970092086 12.3342;9.55312;12.7573;10.3381;35.2747;31.2319 3.46407;4.27871;9.63387;4.23628;15.546;16.4725 46.5267;37.8054;40.2833;21.7065;96.5441;67.1945 0 6 0 6 360243;304951;304477;315740;361308;361921 TOP2A_10059;NUF2_33136;KNTC1_8976;KIF23_32798;KIF20A_8961;ECT2_8523 18.581553333333332 12.54575 11.498790356357787 8.938571666666666 6.95629 5.9109669471835735 51.67675 43.405 26.460701483048393 12.3342;9.55312;12.7573;10.3381;35.2747;31.2319 3.46407;4.27871;9.63387;4.23628;15.546;16.4725 46.5267;37.8054;40.2833;21.7065;96.5441;67.1945 0 Exp 4,2(0.34);Exp 5,3(0.5);Hill,1(0.17) 1.9803829215846465 12.099608540534973 1.595955729484558 2.846071243286133 0.44553332501028003 1.8630624413490295 9.380604782777917 27.782501883888756 4.208813050361525 13.668330282971809 30.503779155938933 72.84972084406107 DOWN 0.0 1.0 0.0 GO:0006950 3 response to stress 773 821 32 31 25 22 18 18 20 803 1706 0.98352 0.035842 0.053767 2.19 24522;360243;363328;89829;363140;338475;24314;24587;291885;499271;24450;361921;170568;24296;60628;24253;25612;25748 zfp354a;top2a;ticam1;socs3;rassf1;nrep;nqo1;nefh;mcm5;itgax;hmgcs2;ect2;dmbt1;cyp1a1;cxcr4;cebpb;asns;alas2 ZFP354A_10203;TOP2A_10059;TICAM1_10015;SOCS3_32863;RASSF1_32475;NREP_9364;NQO1_33055;NEFH_33218;MCM5_9209;ITGAX_32980;HMGCS2_8812;ECT2_8523;DMBT1_32993;CYP1A1_8415;CXCR4_8411;CEBPB_32843,CEBPB_8282;ASNS_8091;ALAS2_8019 24253(-0.009836) 221.35700722222248 82.30685 1.65461E-12 318.4207518419125 250.2290562116567 335.8113307672644 140.53524833333358 49.553 1.65461E-12 202.68898989150833 159.9589175720527 216.56544826861426 493.6597877777779 148.59 1.65462E-12 771.4401481740824 521.0872803358346 756.8863947517467 99.2226;12.3342;811.122;809.124;903.848;114.178;40.5511;2.95157E-12;12.5006;148.304;106.351;31.2319;2.64673;49.0449;1.65461E-12;620.8109999999999;157.765;65.3911 71.0566;3.46407;489.389;488.627;608.514;79.0815;21.5832;2.95157E-12;9.67503;95.184;59.8697;16.4725;1.09657;39.2363;1.65461E-12;409.549;99.5663;37.2697 163.536;46.5267;2362.87;2346.74;1171.72;204.229;79.3552;2.95158E-12;36.0856;340.985;208.329;67.1945;8.73928;64.8529;1.65462E-12;1279.85;371.219;133.644 6 13 6 89829;363140;24314;170568;24296;25612 SOCS3_32863;RASSF1_32475;NQO1_33055;DMBT1_32993;CYP1A1_8415;ASNS_8091 327.16328833333336 103.40494999999999 414.33188277356453 209.77056166666668 69.40129999999999 267.1866293041971 673.7710633333332 225.2871 927.8679624460998 809.124;903.848;40.5511;2.64673;49.0449;157.765 488.627;608.514;21.5832;1.09657;39.2363;99.5663 2346.74;1171.72;79.3552;8.73928;64.8529;371.219 12 24522;360243;363328;338475;24587;291885;499271;24450;361921;60628;24253;25748 ZFP354A_10203;TOP2A_10059;TICAM1_10015;NREP_9364;NEFH_33218;MCM5_9209;ITGAX_32980;HMGCS2_8812;ECT2_8523;CXCR4_8411;CEBPB_32843,CEBPB_8282;ALAS2_8019 168.45386666666704 82.30685 263.6373043930835 105.91759166666706 48.5697 164.6822893522014 403.6041500000004 148.59 708.4158328618494 99.2226;12.3342;811.122;114.178;2.95157E-12;12.5006;148.304;106.351;31.2319;1.65461E-12;620.8109999999999;65.3911 71.0566;3.46407;489.389;79.0815;2.95157E-12;9.67503;95.184;59.8697;16.4725;1.65461E-12;409.549;37.2697 163.536;46.5267;2362.87;204.229;2.95158E-12;36.0856;340.985;208.329;67.1945;1.65462E-12;1279.85;133.644 0 Exp 4,4(0.22);Exp 5,2(0.11);Hill,3(0.16);Linear,4(0.22);Poly 2,6(0.32) 2.099205227204275 44.4557968378067 1.5415632724761963 8.822484970092773 1.6260835525946504 1.7765510082244873 74.25412492890484 368.45988951554006 46.897712306897304 234.17278435976982 137.27262187619152 850.0469536793646 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0051049 5 regulation of transport 454 483 8 7 6 7 5 5 33 478 2031 0.24538 0.87388 0.53015 1.04 25106;24587;361921;60628;24253 rgn;nefh;ect2;cxcr4;cebpb RGN_9699;NEFH_33218;ECT2_8523;CXCR4_8411;CEBPB_32843,CEBPB_8282 24253(-0.009836) 280.9755800000009 31.2319 1.65461E-12 373.632802274481 338.5371463528687 378.8752719570686 176.94750000000093 16.4725 1.65461E-12 235.51539574516053 214.81143087593608 239.70368775980637 668.3629000000009 67.1945 1.65462E-12 920.3387481992967 792.648415679552 923.2080950278734 752.835;2.95157E-12;31.2319;1.65461E-12;620.8109999999999 458.716;2.95157E-12;16.4725;1.65461E-12;409.549 1994.77;2.95158E-12;67.1945;1.65462E-12;1279.85 0 6 0 5 25106;24587;361921;60628;24253 RGN_9699;NEFH_33218;ECT2_8523;CXCR4_8411;CEBPB_32843,CEBPB_8282 280.9755800000009 31.2319 373.632802274481 176.94750000000093 16.4725 235.51539574516053 668.3629000000009 67.1945 920.3387481992967 752.835;2.95157E-12;31.2319;1.65461E-12;620.8109999999999 458.716;2.95157E-12;16.4725;1.65461E-12;409.549 1994.77;2.95158E-12;67.1945;1.65462E-12;1279.85 0 Exp 2,1(0.17);Exp 4,1(0.17);Hill,2(0.34);Linear,2(0.34) 1.8588281065070962 11.295875430107117 1.5669527053833008 2.444005012512207 0.34059878778818586 1.7296647429466248 -46.528011047714244 608.479171047716 -29.490846376505004 383.38584637650683 -138.3495812938694 1475.075381293871 DOWN 0.0 1.0 0.0 GO:0046456 6 icosanoid biosynthetic process 13 16 2 2 2 2 2 2 36 14 2495 0.9985 0.022804 0.022804 12.5 266674;29277 cyp4a8;cyp2c11 CYP4A8_32747;CYP2C11_32593 146.70080000000002 146.70080000000002 76.6586 99.05462917844876 171.67184404378622 92.54573723519954 98.6893 98.6893 57.8156 57.80414088436913 113.26135745868211 54.005823632472534 240.913 240.913 112.882 181.0631766041897 286.55787894397946 169.16549285944484 0.0 76.6586 0.5 146.70080000000002 76.6586;216.743 57.8156;139.563 112.882;368.944 1 1 1 266674 CYP4A8_32747 76.6586 76.6586 57.8156 57.8156 112.882 112.882 76.6586 57.8156 112.882 1 29277 CYP2C11_32593 216.743 216.743 139.563 139.563 368.944 368.944 216.743 139.563 368.944 0 Exp 2,1(0.5);Poly 2,1(0.5) 3.6247465533909384 9.926110863685608 1.5729032754898071 8.3532075881958 4.794399158022801 4.963055431842804 9.41808800000004 283.983512 18.576848000000027 178.80175199999996 -10.02776 491.85376 CONFLICT 0.5 0.5 0.0 GO:0003006 3 developmental process involved in reproduction 220 234 10 8 7 6 5 5 33 229 2280 0.87018 0.2671 0.38959 2.14 89829;25106;24587;60628;24253 socs3;rgn;nefh;cxcr4;cebpb SOCS3_32863;RGN_9699;NEFH_33218;CXCR4_8411;CEBPB_32843,CEBPB_8282 24253(-0.009836) 436.554000000001 620.8109999999999 1.65461E-12 404.3363413490047 531.2797617617624 383.54715928709857 271.3784000000009 409.549 1.65461E-12 249.3370796999503 328.4159916027145 234.5844963164566 1124.2720000000008 1279.85 1.65462E-12 1095.944153809854 1407.605741296853 1084.4729969906575 809.124;752.835;2.95157E-12;1.65461E-12;620.8109999999999 488.627;458.716;2.95157E-12;1.65461E-12;409.549 2346.74;1994.77;2.95158E-12;1.65462E-12;1279.85 1 5 1 89829 SOCS3_32863 809.124 809.124 488.627 488.627 2346.74 2346.74 809.124 488.627 2346.74 4 25106;24587;60628;24253 RGN_9699;NEFH_33218;CXCR4_8411;CEBPB_32843,CEBPB_8282 343.4115000000012 310.40550000000144 400.18370848773804 217.06625000000116 204.77450000000147 251.4489507506099 818.6550000000011 639.9250000000014 989.3329974112174 752.835;2.95157E-12;1.65461E-12;620.8109999999999 458.716;2.95157E-12;1.65461E-12;409.549 1994.77;2.95158E-12;1.65462E-12;1279.85 0 Exp 2,1(0.17);Hill,2(0.34);Linear,3(0.5) 1.7939590083636459 10.882455348968506 1.5669527053833008 2.444005012512207 0.31567361555715634 1.72762531042099 82.13757034826682 790.970429651735 52.82481346801518 489.93198653198664 163.6345940347718 2084.90940596523 DOWN 0.2 0.8 0.0 GO:0019752 6 carboxylic acid metabolic process 287 320 12 12 8 11 8 8 30 312 2197 0.95881 0.094889 0.1332 2.5 25044;25106;60671;266674;266684;29277;24296;25612 sds;rgn;gulo;cyp4a8;cyp2d1;cyp2c11;cyp1a1;asns SDS_9798;RGN_9699;GULO_8772;CYP4A8_32747;CYP2D1_32660;CYP2C11_32593;CYP1A1_8415;ASNS_8091 265.9329375 175.877 49.0449 251.11362527206086 214.23122432464922 229.30440892762542 171.22605 105.92015 39.2363 156.97933702750274 139.7163051083266 143.72729004452833 654.8421125 370.0815 64.8529 660.7421346888997 507.4444164157577 599.1783248226564 553.681;752.835;193.989;76.6586;126.747;216.743;49.0449;157.765 377.484;458.716;112.274;57.8156;85.1532;139.563;39.2363;99.5663 1035.66;1994.77;1039.83;112.882;250.579;368.944;64.8529;371.219 6 2 6 25044;60671;266674;266684;24296;25612 SDS_9798;GULO_8772;CYP4A8_32747;CYP2D1_32660;CYP1A1_8415;ASNS_8091 192.98091666666667 142.256 184.38064817161717 128.58823333333333 92.35974999999999 124.84924126982375 479.1704833333333 310.899 445.81466500711 553.681;193.989;76.6586;126.747;49.0449;157.765 377.484;112.274;57.8156;85.1532;39.2363;99.5663 1035.66;1039.83;112.882;250.579;64.8529;371.219 2 25106;29277 RGN_9699;CYP2C11_32593 484.789 484.789 379.07428853985874 299.1395 299.1395 225.67525053603023 1181.857 1181.857 1149.6325896293997 752.835;216.743 458.716;139.563 1994.77;368.944 0 Exp 2,2(0.25);Linear,1(0.13);Poly 2,5(0.63) 2.431344006959121 26.761356592178345 1.5452189445495605 8.822484970092773 3.2386808017711606 1.5927587151527405 91.92007316735254 439.94580183264765 62.44491935605065 280.00718064394937 196.97117332688777 1112.7130516731122 UP 0.75 0.25 0.0 GO:0016999 5 antibiotic metabolic process 46 51 3 3 3 2 2 2 36 49 2460 0.96099 0.17564 0.17564 3.92 266674;24296 cyp4a8;cyp1a1 CYP4A8_32747;CYP1A1_8415 62.85175 62.85175 49.0449 19.525834523650985 52.66632924759405 13.182284401343985 48.52595 48.52595 39.2363 13.137549019699227 41.672902860892385 8.86942411114378 88.86745 88.86745 64.8529 33.96170230428678 71.15172947506562 22.928229673697793 76.6586;49.0449 57.8156;39.2363 112.882;64.8529 2 0 2 266674;24296 CYP4A8_32747;CYP1A1_8415 62.85175 62.85175 19.525834523650985 48.52595 48.52595 13.137549019699227 88.86745 88.86745 33.96170230428678 76.6586;49.0449 57.8156;39.2363 112.882;64.8529 0 0 Poly 2,2(1) 3.725173218444817 10.39538824558258 1.5729032754898071 8.822484970092773 5.12622837701962 5.19769412279129 35.790324 89.913176 30.318236 66.733664 41.798932000000015 135.935968 UP 1.0 0.0 0.0 GO:0000226 5 microtubule cytoskeleton organization 73 80 11 11 6 7 3 3 35 77 2432 0.97038 0.11493 0.11493 3.75 304951;24587;361308 nuf2;nefh;kif20a NUF2_33136;NEFH_33218;KIF20A_8961 14.942606666667652 9.55312 2.95157E-12 18.244479710862933 11.755838504764734 17.27690193439461 6.608236666667651 4.27871 2.95157E-12 8.030538578950594 5.202556213468107 7.610111791140525 44.78316666666765 37.8054 2.95158E-12 48.64882045788162 35.851629210400134 47.04729042074024 9.55312;2.95157E-12;35.2747 4.27871;2.95157E-12;15.546 37.8054;2.95158E-12;96.5441 0 3 0 3 304951;24587;361308 NUF2_33136;NEFH_33218;KIF20A_8961 14.942606666667652 9.55312 18.244479710862933 6.608236666667651 4.27871 8.030538578950594 44.78316666666765 37.8054 48.64882045788162 9.55312;2.95157E-12;35.2747 4.27871;2.95157E-12;15.546 37.8054;2.95158E-12;96.5441 0 Exp 4,1(0.34);Exp 5,1(0.34);Hill,1(0.34) 2.024628686704796 6.131895542144775 1.7776354551315308 2.444005012512207 0.3527334562084045 1.9102550745010376 -5.702965667023458 35.588179000358764 -2.479173209510158 15.69564654284546 -10.268156124079177 99.83448945741449 DOWN 0.0 1.0 0.0 GO:1905956 6 positive regulation of endothelial tube morphogenesis 1 1 1 1 1 1 1 1 37 0 2509 1.0 0.01492 0.01492 100.0 499271 itgax ITGAX_32980 148.304 148.304 148.304 148.304 95.184 95.184 95.184 95.18400000000001 340.985 340.985 340.985 340.985 0.0 148.304 0.0 148.304 148.304 95.184 340.985 0 1 0 1 499271 ITGAX_32980 148.304 148.304 95.184 95.184 340.985 340.985 148.304 95.184 340.985 0 Poly 2,1(1) 1.8672927618026733 1.8672927618026733 1.8672927618026733 1.8672927618026733 0.0 1.8672927618026733 148.304 148.304 95.184 95.184 340.985 340.985 DOWN 0.0 1.0 0.0 GO:0065009 3 regulation of molecular function 643 686 21 18 13 14 8 8 30 678 1831 0.26713 0.8435 0.46673 1.17 363328;89829;299276;25106;24314;83928;361921;24253 ticam1;socs3;serpina3m;rgn;nqo1;fetub;ect2;cebpb TICAM1_10015;SOCS3_32863;SERPINA3M_9809;RGN_9699;NQO1_33055;FETUB_33027;ECT2_8523;CEBPB_32843,CEBPB_8282 24253(-0.009836) 509.8044999999999 583.356 31.2319 317.1633964049402 511.5139341715467 298.32642744790235 320.3283375 395.8565 16.4725 196.3975009345583 322.7082432016141 184.5477627380081 1253.2675875 1128.234 67.1945 922.0097024160806 1234.8637883519514 891.8031729433962 811.122;809.124;466.86;752.835;40.5511;545.901;31.2319;620.8109999999999 489.389;488.627;296.126;458.716;21.5832;382.164;16.4725;409.549 2362.87;2346.74;918.743;1994.77;79.3552;976.618;67.1945;1279.85 3 6 3 89829;24314;83928 SOCS3_32863;NQO1_33055;FETUB_33027 465.1920333333333 545.901 390.5912551874444 297.45806666666664 382.164 244.77295425764126 1134.2377333333334 976.618 1141.8806606076719 809.124;40.5511;545.901 488.627;21.5832;382.164 2346.74;79.3552;976.618 5 363328;299276;25106;361921;24253 TICAM1_10015;SERPINA3M_9809;RGN_9699;ECT2_8523;CEBPB_32843,CEBPB_8282 536.5719799999999 620.8109999999999 312.0384497149383 334.0505 409.549 192.13641882722277 1324.6855 1279.85 904.8374776207052 811.122;466.86;752.835;31.2319;620.8109999999999 489.389;296.126;458.716;16.4725;409.549 2362.87;918.743;1994.77;67.1945;1279.85 0 Exp 2,3(0.34);Exp 4,2(0.23);Linear,4(0.45) 1.7589938258547144 16.07360804080963 1.5054508447647095 2.5798087120056152 0.3547932099234949 1.671766996383667 290.0214794247516 729.5875205752484 184.2318128754609 456.42486212453906 614.3474608597628 1892.1877141402372 DOWN 0.375 0.625 0.0 GO:0009612 4 response to mechanical stimulus 121 126 3 3 3 2 2 2 36 124 2385 0.71041 0.56875 0.7121 1.59 60628;25612 cxcr4;asns CXCR4_8411;ASNS_8091 78.88250000000082 78.88250000000082 1.65461E-12 111.5567013338945 104.25521902378026 105.6283478578569 49.78315000000082 49.78315000000082 1.65461E-12 70.40400590765297 65.79600300375525 66.66259164782853 185.60950000000082 185.60950000000082 1.65462E-12 262.49147220528783 245.3111789737177 248.54213332137047 1.65461E-12;157.765 1.65461E-12;99.5663 1.65462E-12;371.219 1 1 1 25612 ASNS_8091 157.765 157.765 99.5663 99.5663 371.219 371.219 157.765 99.5663 371.219 1 60628 CXCR4_8411 1.65461E-12 1.65461E-12 1.65461E-12 1.65461E-12 1.65462E-12 1.65462E-12 1.65461E-12 1.65461E-12 1.65462E-12 0 Hill,1(0.5);Poly 2,1(0.5) 1.6705577419194637 3.3442479372024536 1.5997679233551025 1.744480013847351 0.10232690050675025 1.6721239686012268 -75.72719999999754 233.49219999999917 -47.79182399999753 147.35812399999918 -178.18511999999754 549.4041199999992 CONFLICT 0.5 0.5 0.0 GO:0006875 8 cellular metal ion homeostasis 132 139 5 4 4 5 4 4 34 135 2374 0.94706 0.15007 0.15007 2.88 25106;24567;60628;25748 rgn;mt1;cxcr4;alas2 RGN_9699;MT1A_9255;CXCR4_8411;ALAS2_8019 246.7035250000004 116.98955 1.65461E-12 344.4841215201395 194.6095200709222 278.271049303467 149.8849250000004 70.41185 1.65461E-12 210.29413301458428 117.89538817785073 170.1271504787659 834.3410000000003 671.297 1.65462E-12 944.10955526217 761.2891847244955 833.3464764874047 752.835;168.588;1.65461E-12;65.3911 458.716;103.554;1.65461E-12;37.2697 1994.77;1208.95;1.65462E-12;133.644 0 4 0 4 25106;24567;60628;25748 RGN_9699;MT1A_9255;CXCR4_8411;ALAS2_8019 246.7035250000004 116.98955 344.4841215201395 149.8849250000004 70.41185 210.29413301458428 834.3410000000003 671.297 944.10955526217 752.835;168.588;1.65461E-12;65.3911 458.716;103.554;1.65461E-12;37.2697 1994.77;1208.95;1.65462E-12;133.644 0 Exp 2,1(0.25);Exp 5,1(0.25);Hill,1(0.25);Poly 2,1(0.25) 1.8043762861595447 7.240801572799683 1.7132161855697632 2.06825590133667 0.17263598334504462 1.7296647429466248 -90.89091408973633 584.2979640897372 -56.20332535429222 355.97317535429306 -90.88636415692622 1759.568364156927 DOWN 0.0 1.0 0.0 GO:0051276 6 chromosome organization 85 90 10 10 5 7 3 3 35 87 2422 0.95695 0.14876 0.14876 3.33 360243;304951;291885 top2a;nuf2;mcm5 TOP2A_10059;NUF2_33136;MCM5_9209 11.46264 12.3342 9.55312 1.6557844705154012 11.774123359007273 1.3994743586498533 5.805936666666667 4.27871 3.46407 3.3753995317492906 4.41628350449294 2.4765957029541075 40.13923333333333 37.8054 36.0856 5.598144855515351 43.38999978605049 5.44675846178714 12.3342;9.55312;12.5006 3.46407;4.27871;9.67503 46.5267;37.8054;36.0856 0 3 0 3 360243;304951;291885 TOP2A_10059;NUF2_33136;MCM5_9209 11.46264 12.3342 1.6557844705154012 5.805936666666667 4.27871 3.3753995317492906 40.13923333333333 37.8054 5.598144855515351 12.3342;9.55312;12.5006 3.46407;4.27871;9.67503 46.5267;37.8054;36.0856 0 Exp 5,2(0.67);Hill,1(0.34) 2.129633828955914 6.532877326011658 1.7765510082244873 2.846071243286133 0.58273810760135 1.9102550745010376 9.588943484846734 13.336336515153267 1.9863125232418066 9.625560810091526 33.80433607231645 46.47413059435021 DOWN 0.0 1.0 0.0 GO:0032467 7 positive regulation of cytokinesis 11 12 3 2 2 2 2 2 36 10 2499 0.99939 0.013022 0.013022 16.67 315740;361921 kif23;ect2 KIF23_32798;ECT2_8523 20.785 20.785 10.3381 14.774147664755489 14.127717217108826 11.385807442480374 10.35439 10.35439 4.23628 8.652314138090459 6.45562688684353 6.667970629747925 44.450500000000005 44.450500000000005 21.7065 32.16487326261366 29.956895235517052 24.788100247133 0.0 10.3381 0.5 20.785 10.3381;31.2319 4.23628;16.4725 21.7065;67.1945 0 2 0 2 315740;361921 KIF23_32798;ECT2_8523 20.785 20.785 14.774147664755489 10.35439 10.35439 8.652314138090459 44.450500000000005 44.450500000000005 32.16487326261366 10.3381;31.2319 4.23628;16.4725 21.7065;67.1945 0 Exp 4,1(0.5);Exp 5,1(0.5) 1.8540235522235824 3.7497769594192505 1.595955729484558 2.1538212299346924 0.39447047835831694 1.8748884797096252 0.30907600000000457 41.260923999999996 -1.6371056 22.345885599999995 -0.12773999999998864 89.02874 DOWN 0.0 1.0 0.0 GO:0071280 7 cellular response to copper ion 11 12 2 2 2 2 2 2 36 10 2499 0.99939 0.013022 0.013022 16.67 24567;24296 mt1;cyp1a1 MT1A_9255;CYP1A1_8415 108.81645 108.81645 49.0449 84.52973665406155 95.28702901333662 82.33581185812321 71.39515 71.39515 39.2363 45.47948182032203 64.11592401210176 44.29908582216131 636.9014500000001 636.9014500000001 64.8529 808.9988177458636 507.41701036675727 788.0016795032452 0.0 49.0449 0.5 108.81645 168.588;49.0449 103.554;39.2363 1208.95;64.8529 1 1 1 24296 CYP1A1_8415 49.0449 49.0449 39.2363 39.2363 64.8529 64.8529 49.0449 39.2363 64.8529 1 24567 MT1A_9255 168.588 168.588 103.554 103.554 1208.95 1208.95 168.588 103.554 1208.95 0 Poly 2,2(1) 4.271669065347695 10.890740871429443 2.06825590133667 8.822484970092773 4.775961176204741 5.445370435714722 -8.335787999999994 225.968688 8.363804000000009 134.426496 -484.3137079999999 1758.116608 CONFLICT 0.5 0.5 0.0 GO:0007339 5 binding of sperm to zona pellucida 9 9 1 1 1 1 1 1 37 8 2501 0.99269 0.12672 0.12672 11.11 83928 fetub FETUB_33027 545.901 545.901 545.901 545.901 382.164 382.164 382.164 382.164 976.618 976.618 976.618 976.6179999999999 0.0 545.901 0.0 545.901 545.901 382.164 976.618 1 0 1 83928 FETUB_33027 545.901 545.901 382.164 382.164 976.618 976.618 545.901 382.164 976.618 0 0 Exp 2,1(1) 1.5054508447647095 1.5054508447647095 1.5054508447647095 1.5054508447647095 0.0 1.5054508447647095 545.901 545.901 382.164 382.164 976.618 976.618 UP 1.0 0.0 0.0 GO:1901568 4 fatty acid derivative metabolic process 46 57 5 5 4 5 4 4 34 53 2456 0.99866 0.0094478 0.0094478 7.02 24450;266674;266684;29277 hmgcs2;cyp4a8;cyp2d1;cyp2c11 HMGCS2_8812;CYP4A8_32747;CYP2D1_32660;CYP2C11_32593 131.6249 116.549 76.6586 60.35712886069607 127.99532749547245 48.496598712325785 85.600375 72.51145 57.8156 38.06234455962786 79.85584035900713 33.47038438663714 235.18349999999998 229.454 112.882 106.15666701154487 238.99922728241185 78.35351877549633 1.5 116.549 106.351;76.6586;126.747;216.743 59.8697;57.8156;85.1532;139.563 208.329;112.882;250.579;368.944 2 2 2 266674;266684 CYP4A8_32747;CYP2D1_32660 101.7028 101.7028 35.41784729878428 71.4844 71.4844 19.3306023413654 181.7305 181.7305 97.36648244904406 76.6586;126.747 57.8156;85.1532 112.882;250.579 2 24450;29277 HMGCS2_8812;CYP2C11_32593 161.547 161.547 78.05893178874537 99.71634999999999 99.71634999999999 56.35167284513388 288.6365 288.6365 113.5719556602773 106.351;216.743 59.8697;139.563 208.329;368.944 0 Exp 2,1(0.25);Exp 4,1(0.25);Poly 2,2(0.5) 2.699367867653382 14.07183563709259 1.5671749114990234 8.3532075881958 3.2583696725908156 2.075726568698883 72.47491371651788 190.77488628348212 48.299277331564696 122.9014726684353 131.1499663286861 339.2170336713139 CONFLICT 0.5 0.5 0.0 GO:0016114 6 terpenoid biosynthetic process 8 8 2 2 2 2 2 2 36 6 2503 0.99984 0.0057362 0.0057362 25.0 24450;24296 hmgcs2;cyp1a1 HMGCS2_8812;CYP1A1_8415 77.69794999999999 77.69794999999999 49.0449 40.52153191335444 76.46721092732619 40.48413406848401 49.553 49.553 39.2363 14.590017058934528 49.10986512287335 14.576551743857259 136.59095000000002 136.59095000000002 64.8529 101.45292324819917 133.50957398130646 101.35929103573996 0.0 49.0449 0.0 49.0449 106.351;49.0449 59.8697;39.2363 208.329;64.8529 1 1 1 24296 CYP1A1_8415 49.0449 49.0449 39.2363 39.2363 64.8529 64.8529 49.0449 39.2363 64.8529 1 24450 HMGCS2_8812 106.351 106.351 59.8697 59.8697 208.329 208.329 106.351 59.8697 208.329 0 Exp 4,1(0.5);Poly 2,1(0.5) 4.769613967746002 11.401034832000732 2.578549861907959 8.822484970092773 4.415128856286241 5.700517416000366 21.537971999999982 133.85792800000002 29.332267999999996 69.773732 -4.015627999999964 277.19752800000003 CONFLICT 0.5 0.5 0.0 GO:0022414 2 reproductive process 343 368 21 19 14 16 11 11 27 357 2152 0.99463 0.015212 0.017748 2.99 360243;89829;25106;304951;24587;361308;83928;24296;60628;24253;25748 top2a;socs3;rgn;nuf2;nefh;kif20a;fetub;cyp1a1;cxcr4;cebpb;alas2 TOP2A_10059;SOCS3_32863;RGN_9699;NUF2_33136;NEFH_33218;KIF20A_8961;FETUB_33027;CYP1A1_8415;CXCR4_8411;CEBPB_32843,CEBPB_8282;ALAS2_8019 24253(-0.009836) 263.6608200000004 49.0449 1.65461E-12 338.87138759651657 277.6172666495101 336.20809843696213 167.16825272727314 37.2697 1.65461E-12 214.1867062156811 177.7828579354854 212.08998435120486 634.3046454545458 96.5441 1.65462E-12 876.7730531858218 660.7291982044283 889.5749877275832 12.3342;809.124;752.835;9.55312;2.95157E-12;35.2747;545.901;49.0449;1.65461E-12;620.8109999999999;65.3911 3.46407;488.627;458.716;4.27871;2.95157E-12;15.546;382.164;39.2363;1.65461E-12;409.549;37.2697 46.5267;2346.74;1994.77;37.8054;2.95158E-12;96.5441;976.618;64.8529;1.65462E-12;1279.85;133.644 3 9 3 89829;83928;24296 SOCS3_32863;FETUB_33027;CYP1A1_8415 468.0233 545.901 385.9776699268625 303.3424333333333 382.164 234.83532494167773 1129.4036333333333 976.618 1148.5903410709159 809.124;545.901;49.0449 488.627;382.164;39.2363 2346.74;976.618;64.8529 8 360243;25106;304951;24587;361308;60628;24253;25748 TOP2A_10059;RGN_9699;NUF2_33136;NEFH_33218;KIF20A_8961;CXCR4_8411;CEBPB_32843,CEBPB_8282;ALAS2_8019 187.02489000000057 23.804450000000003 311.2426830168235 116.10293500000057 9.912355 197.11223623915538 448.64252500000055 71.5354 759.4789489752499 12.3342;752.835;9.55312;2.95157E-12;35.2747;1.65461E-12;620.8109999999999;65.3911 3.46407;458.716;4.27871;2.95157E-12;15.546;1.65461E-12;409.549;37.2697 46.5267;1994.77;37.8054;2.95158E-12;96.5441;1.65462E-12;1279.85;133.644 0 Exp 2,2(0.17);Exp 4,1(0.09);Exp 5,2(0.17);Hill,3(0.25);Linear,3(0.25);Poly 2,1(0.09) 2.0993928640840953 29.457569122314453 1.5054508447647095 8.822484970092773 2.0420750020369764 1.7424405813217163 63.40062728221034 463.92101271779046 40.59199803499912 293.7445074195472 116.16488202955384 1152.444408879538 DOWN 0.2727272727272727 0.7272727272727273 0.0 GO:0044271 5 cellular nitrogen compound biosynthetic process 201 229 5 5 5 4 4 4 34 225 2284 0.74748 0.45006 0.77184 1.75 114519;25612;25748;54223 nfil3;asns;alas2;adcy4 NFIL3_9304;ASNS_8091;ALAS2_8019;ADCY4_7988 265.22727499999996 139.543 65.3911 303.19265450287963 248.88198098010466 296.86228371424244 153.2739 91.05895 37.2697 162.43119658848383 144.21346299057592 159.3542790690605 705.43325 300.5045 133.644 926.2516494586753 656.0319381780104 906.1750968160638 121.321;157.765;65.3911;716.432 82.5516;99.5663;37.2697;393.708 229.79;371.219;133.644;2087.08 1 3 1 25612 ASNS_8091 157.765 157.765 99.5663 99.5663 371.219 371.219 157.765 99.5663 371.219 3 114519;25748;54223 NFIL3_9304;ALAS2_8019;ADCY4_7988 301.0480333333333 121.321 360.81840065509874 171.17643333333334 82.5516 194.0433875174399 816.8380000000001 229.79 1101.1117414922064 121.321;65.3911;716.432 82.5516;37.2697;393.708 229.79;133.644;2087.08 0 Exp 2,1(0.25);Exp 5,1(0.25);Poly 2,2(0.5) 1.7678214454596355 7.122390151023865 1.5997679233551025 2.1583378314971924 0.2560632553201932 1.682142198085785 -31.901526412821966 562.356076412822 -5.908672656714089 312.4564726567141 -202.29336646950185 1613.1598664695016 DOWN 0.25 0.75 0.0 GO:0071248 6 cellular response to metal ion 94 103 6 6 5 5 4 4 34 99 2410 0.98298 0.064943 0.064943 3.88 24314;24567;361921;24296 nqo1;mt1;ect2;cyp1a1 NQO1_33055;MT1A_9255;ECT2_8523;CYP1A1_8415 72.35397499999999 44.798 31.2319 64.56714452316932 75.49494208779785 62.380047011461755 45.2115 30.409750000000003 16.4725 40.098948461607655 48.85057806252999 37.67668388203159 355.08815000000004 73.27485 64.8529 569.276726104862 355.886214820886 569.4796553484258 40.5511;168.588;31.2319;49.0449 21.5832;103.554;16.4725;39.2363 79.3552;1208.95;67.1945;64.8529 2 2 2 24314;24296 NQO1_33055;CYP1A1_8415 44.798 44.798 6.006023578042245 30.409750000000003 30.409750000000003 12.482626718964237 72.10405 72.10405 10.254674672801642 40.5511;49.0449 21.5832;39.2363 79.3552;64.8529 2 24567;361921 MT1A_9255;ECT2_8523 99.90995 99.90995 97.12542974733753 60.01325 60.01325 61.57591916589635 638.07225 638.07225 807.3430565070371 168.588;31.2319 103.554;16.4725 1208.95;67.1945 0 Exp 4,2(0.5);Poly 2,2(0.5) 3.173204704241033 15.624370813369751 2.06825590133667 8.822484970092773 3.2852215335531625 2.366814970970154 9.078173367294063 135.62977663270593 5.914530507624498 84.5084694923755 -202.80304158276476 912.9793415827646 CONFLICT 0.5 0.5 0.0 GO:0032268 6 regulation of cellular protein metabolic process 600 637 25 21 15 15 9 9 29 628 1881 0.5118 0.63726 1.0 1.41 360772;363328;89829;299276;25106;363140;83928;361921;60628 zfand2a;ticam1;socs3;serpina3m;rgn;rassf1;fetub;ect2;cxcr4 ZFAND2A_10197;TICAM1_10015;SOCS3_32863;SERPINA3M_9809;RGN_9699;RASSF1_32475;FETUB_33027;ECT2_8523;CXCR4_8411 585.2176555555557 752.835 1.65461E-12 358.10482920004387 689.3667314470863 278.2634731799991 380.847277777778 458.716 1.65461E-12 239.89429106966935 454.4134660516759 193.14205739212207 1236.7483888888892 1171.72 1.65462E-12 876.6638768814049 1342.7106385380553 706.6791131148234 946.037;811.122;809.124;466.86;752.835;903.848;545.901;31.2319;1.65461E-12 687.617;489.389;488.627;296.126;458.716;608.514;382.164;16.4725;1.65461E-12 1292.08;2362.87;2346.74;918.743;1994.77;1171.72;976.618;67.1945;1.65462E-12 4 5 4 360772;89829;363140;83928 ZFAND2A_10197;SOCS3_32863;RASSF1_32475;FETUB_33027 801.2275 856.486 179.58724400227734 541.7304999999999 548.5705 134.19433220644422 1446.7894999999999 1231.9 613.8866347795823 946.037;809.124;903.848;545.901 687.617;488.627;608.514;382.164 1292.08;2346.74;1171.72;976.618 5 363328;299276;25106;361921;60628 TICAM1_10015;SERPINA3M_9809;RGN_9699;ECT2_8523;CXCR4_8411 412.4097800000003 466.86 385.09868673119587 252.14070000000032 296.126 234.52571827349723 1068.7155000000002 918.743 1083.9858960081074 811.122;466.86;752.835;31.2319;1.65461E-12 489.389;296.126;458.716;16.4725;1.65461E-12 2362.87;918.743;1994.77;67.1945;1.65462E-12 0 Exp 2,3(0.34);Exp 4,1(0.12);Hill,1(0.12);Linear,2(0.23);Poly 2,2(0.23) 1.8718284338019495 17.20784306526184 1.5054508447647095 2.6542086601257324 0.43567005849437124 1.7404011487960815 351.25583381152705 819.1794772995843 224.11634094559398 537.5782146099621 663.9946559930378 1809.5021217847407 CONFLICT 0.4444444444444444 0.5555555555555556 0.0 GO:0042035 6 regulation of cytokine biosynthetic process 40 43 3 3 3 2 2 2 36 41 2468 0.97492 0.13374 0.13374 4.65 363328;24253 ticam1;cebpb TICAM1_10015;CEBPB_32843,CEBPB_8282 24253(-0.009836) 715.9665 715.9665 620.8109999999999 134.57019863439257 725.5093151862465 133.89177613708094 449.469 449.469 409.549 56.455405409933775 453.47243839541557 56.17079100411645 1821.36 1821.36 1279.85 765.8107861606546 1875.6661604584529 761.9500259679244 811.122;620.8109999999999 489.389;409.549 2362.87;1279.85 0 3 0 2 363328;24253 TICAM1_10015;CEBPB_32843,CEBPB_8282 715.9665 715.9665 134.57019863439257 449.469 449.469 56.455405409933775 1821.36 1821.36 765.8107861606546 811.122;620.8109999999999 489.389;409.549 2362.87;1279.85 0 Linear,3(1) 1.5924445916045327 4.780282974243164 1.5415632724761963 1.671766996383667 0.06902133561518818 1.5669527053833008 529.46172 902.47128 371.2258 527.7122 760.0004000000001 2882.7195999999994 DOWN 0.0 1.0 0.0 GO:0032886 5 regulation of microtubule-based process 52 56 7 6 3 5 2 2 36 54 2455 0.95063 0.20281 0.20281 3.57 363140;24587 rassf1;nefh RASSF1_32475;NEFH_33218 451.92400000000146 451.92400000000146 2.95157E-12 639.1170499618964 708.4428817135556 526.1812712372537 304.2570000000015 304.2570000000015 2.95157E-12 430.28437584694876 476.957864290282 354.25057098723 585.8600000000015 585.8600000000015 2.95158E-12 828.5311576518994 918.4029763427117 682.1247810850003 903.848;2.95157E-12 608.514;2.95157E-12 1171.72;2.95158E-12 1 1 1 363140 RASSF1_32475 903.848 903.848 608.514 608.514 1171.72 1171.72 903.848 608.514 1171.72 1 24587 NEFH_33218 2.95157E-12 2.95157E-12 2.95157E-12 2.95157E-12 2.95158E-12 2.95158E-12 2.95157E-12 2.95157E-12 2.95158E-12 0 Hill,1(0.5);Poly 2,1(0.5) 2.5469391962904413 5.0982136726379395 2.444005012512207 2.6542086601257324 0.14863642465767124 2.5491068363189697 -433.84703999999545 1337.6950399999982 -292.08671999999564 900.6007199999985 -562.4255999999955 1734.1455999999985 CONFLICT 0.5 0.5 0.0 GO:1901570 5 fatty acid derivative biosynthetic process 18 23 3 3 3 3 3 3 35 20 2489 0.9997 0.0044176 0.0044176 13.04 24450;266674;29277 hmgcs2;cyp4a8;cyp2c11 HMGCS2_8812;CYP4A8_32747;CYP2C11_32593 133.25086666666667 106.351 76.6586 73.81471330875256 128.44872091199534 60.04789060155567 85.74943333333333 59.8697 57.8156 46.61523141359844 77.93183564478653 41.19709789783978 230.05166666666665 208.329 112.882 129.40572880028668 234.79344575951208 96.51740457467648 0.5 91.5048 1.5 161.547 106.351;76.6586;216.743 59.8697;57.8156;139.563 208.329;112.882;368.944 1 2 1 266674 CYP4A8_32747 76.6586 76.6586 57.8156 57.8156 112.882 112.882 76.6586 57.8156 112.882 2 24450;29277 HMGCS2_8812;CYP2C11_32593 161.547 161.547 78.05893178874537 99.71634999999999 99.71634999999999 56.35167284513388 288.6365 288.6365 113.5719556602773 106.351;216.743 59.8697;139.563 208.329;368.944 0 Exp 2,1(0.34);Exp 4,1(0.34);Poly 2,1(0.34) 3.2357647658149578 12.504660725593567 1.5729032754898071 8.3532075881958 3.6590190735917605 2.578549861907959 49.72165525269851 216.78007808063484 32.99933317957695 138.4995334870897 83.6152992459173 376.48803408741605 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0043547 7 positive regulation of GTPase activity 63 68 2 2 2 2 2 2 36 66 2443 0.92093 0.26959 0.26959 2.94 25106;361921 rgn;ect2 RGN_9699;ECT2_8523 392.03345 392.03345 31.2319 510.2504453352344 515.6635126318372 479.36075370445303 237.59425000000002 237.59425000000002 16.4725 312.7133777856729 313.3624827078734 293.78224328705795 1030.98225 1030.98225 67.1945 1363.00170729905 1361.2278930586212 1280.4879087995018 752.835;31.2319 458.716;16.4725 1994.77;67.1945 0 2 0 2 25106;361921 RGN_9699;ECT2_8523 392.03345 392.03345 510.2504453352344 237.59425000000002 237.59425000000002 312.7133777856729 1030.98225 1030.98225 1363.00170729905 752.835;31.2319 458.716;16.4725 1994.77;67.1945 0 Exp 2,1(0.5);Exp 4,1(0.5) 1.9218426572003118 3.868670701980591 1.7148494720458984 2.1538212299346924 0.31039990675254553 1.9343353509902954 -315.13758800000005 1099.204488 -195.8043799999999 670.9928799999999 -858.0417399999997 2920.0062399999997 DOWN 0.0 1.0 0.0 GO:0031100 5 animal organ regeneration 72 80 8 8 5 7 4 4 34 76 2433 0.994 0.029623 0.029623 5.0 89829;25106;24253;25748 socs3;rgn;cebpb;alas2 SOCS3_32863;RGN_9699;CEBPB_32843,CEBPB_8282;ALAS2_8019 24253(-0.009836) 562.0402750000001 686.823 65.3911 340.37596634354554 507.11978323617376 381.0329702821031 348.54042499999997 434.1325 37.2697 210.05905224275037 312.38035810310737 234.80361819435933 1438.751 1637.31 133.644 976.7556776956386 1329.7632663861712 1096.4756503766932 3.0 809.124 809.124;752.835;620.8109999999999;65.3911 488.627;458.716;409.549;37.2697 2346.74;1994.77;1279.85;133.644 1 4 1 89829 SOCS3_32863 809.124 809.124 488.627 488.627 2346.74 2346.74 809.124 488.627 2346.74 3 25106;24253;25748 RGN_9699;CEBPB_32843,CEBPB_8282;ALAS2_8019 479.67903333333334 620.8109999999999 364.8060483643374 301.8449 409.549 230.44386694709414 1136.088 1279.85 938.854691340465 752.835;620.8109999999999;65.3911 458.716;409.549;37.2697 1994.77;1279.85;133.644 0 Exp 2,1(0.2);Exp 5,1(0.2);Linear,3(0.6) 1.680288418432356 8.407186508178711 1.5669527053833008 1.7404011487960815 0.06856245957211204 1.7132161855697632 228.47182798332534 895.6087220166748 142.68255380210474 554.3982961978953 481.5304358582739 2395.971564141726 DOWN 0.25 0.75 0.0 GO:0009725 4 response to hormone 388 419 15 12 10 10 7 7 31 412 2097 0.72023 0.43746 0.66362 1.67 360243;89829;24314;24587;24450;266674;25612 top2a;socs3;nqo1;nefh;hmgcs2;cyp4a8;asns TOP2A_10059;SOCS3_32863;NQO1_33055;NEFH_33218;HMGCS2_8812;CYP4A8_32747;ASNS_8091 171.82627142857186 76.6586 2.95157E-12 286.3230023608225 195.1443291663401 304.2705023776247 104.41798142857185 57.8156 2.95157E-12 173.08612894068176 116.57862229263084 184.65432584627268 452.1502714285718 112.882 2.95158E-12 844.4444325151903 521.3878670640213 898.5457150527516 12.3342;809.124;40.5511;2.95157E-12;106.351;76.6586;157.765 3.46407;488.627;21.5832;2.95157E-12;59.8697;57.8156;99.5663 46.5267;2346.74;79.3552;2.95158E-12;208.329;112.882;371.219 4 3 4 89829;24314;266674;25612 SOCS3_32863;NQO1_33055;CYP4A8_32747;ASNS_8091 271.024675 117.2118 362.06577553015023 166.89802500000002 78.69095 216.83977829623996 727.54905 242.0505 1087.308801066258 809.124;40.5511;76.6586;157.765 488.627;21.5832;57.8156;99.5663 2346.74;79.3552;112.882;371.219 3 360243;24587;24450 TOP2A_10059;NEFH_33218;HMGCS2_8812 39.56173333333432 12.3342 58.16904442066431 21.11125666666765 3.46407 33.61045436257253 84.95190000000099 46.5267 109.35088045612504 12.3342;2.95157E-12;106.351 3.46407;2.95157E-12;59.8697 46.5267;2.95158E-12;208.329 0 Exp 4,2(0.29);Hill,2(0.29);Linear,1(0.15);Poly 2,2(0.29) 2.135656112343525 15.361507177352905 1.5729032754898071 2.846071243286133 0.5368192485828934 2.444005012512207 -40.28477705897501 383.93731991611867 -23.806017291561133 232.64198014870482 -173.42291861694076 1077.7234614740844 CONFLICT 0.5714285714285714 0.42857142857142855 0.0 GO:0010951 8 negative regulation of endopeptidase activity 84 91 4 3 3 3 2 2 36 89 2420 0.84768 0.39659 0.39659 2.2 299276;83928 serpina3m;fetub SERPINA3M_9809;FETUB_33027 506.3805 506.3805 466.86 55.890427091765886 501.5475648503981 55.47094118706988 339.145 339.145 296.126 60.83805323972824 333.8842356574252 60.38143290005471 947.6805 947.6805 918.743 40.923804961171435 944.1417527449905 40.61665112032859 466.86;545.901 296.126;382.164 918.743;976.618 1 1 1 83928 FETUB_33027 545.901 545.901 382.164 382.164 976.618 976.618 545.901 382.164 976.618 1 299276 SERPINA3M_9809 466.86 466.86 296.126 296.126 918.743 918.743 466.86 296.126 918.743 0 Exp 2,2(1) 1.5515174361715292 3.1044445037841797 1.5054508447647095 1.5989936590194702 0.06614475829081497 1.5522222518920898 428.92032000000006 583.8406799999999 254.82775999999998 423.46223999999995 890.9630000000001 1004.398 CONFLICT 0.5 0.5 0.0 GO:0072593 4 reactive oxygen species metabolic process 40 44 4 3 3 2 2 2 36 42 2467 0.97336 0.13884 0.13884 4.55 24314;24296 nqo1;cyp1a1 NQO1_33055;CYP1A1_8415 44.798 44.798 40.5511 6.006023578042245 45.396962457631986 5.945990848352757 30.409750000000003 30.409750000000003 21.5832 12.482626718964237 31.654604383294078 12.357857619093508 72.10405 72.10405 64.8529 10.254674672801642 71.08138249554777 10.152174889927451 40.5511;49.0449 21.5832;39.2363 79.3552;64.8529 2 0 2 24314;24296 NQO1_33055;CYP1A1_8415 44.798 44.798 6.006023578042245 30.409750000000003 30.409750000000003 12.482626718964237 72.10405 72.10405 10.254674672801642 40.5511;49.0449 21.5832;39.2363 79.3552;64.8529 0 0 Exp 4,1(0.5);Poly 2,1(0.5) 4.770778090352132 11.402293682098389 2.5798087120056152 8.822484970092773 4.414238714845691 5.701146841049194 36.474076000000004 53.121924 13.109712000000005 47.709788 57.891796000000014 86.31630399999999 UP 1.0 0.0 0.0 GO:0022412 3 cellular process involved in reproduction in multicellular organism 59 60 8 7 5 5 3 3 35 57 2452 0.9887 0.058524 0.058524 5.0 360243;361308;60628 top2a;kif20a;cxcr4 TOP2A_10059;KIF20A_8961;CXCR4_8411 15.869633333333885 12.3342 1.65461E-12 17.90113353012337 12.837590276687992 13.15747893643259 6.3366900000005515 3.46407 1.65461E-12 8.161402345693388 4.454738742151101 5.984347120760288 47.69026666666722 46.5267 1.65462E-12 48.282566488777846 42.92564895015738 36.36992628065517 2.0 35.2747 12.3342;35.2747;1.65461E-12 3.46407;15.546;1.65461E-12 46.5267;96.5441;1.65462E-12 0 3 0 3 360243;361308;60628 TOP2A_10059;KIF20A_8961;CXCR4_8411 15.869633333333885 12.3342 17.90113353012337 6.3366900000005515 3.46407 8.161402345693388 47.69026666666722 46.5267 48.282566488777846 12.3342;35.2747;1.65461E-12 3.46407;15.546;1.65461E-12 46.5267;96.5441;1.65462E-12 0 Exp 4,1(0.34);Hill,2(0.67) 2.0665765151960294 6.368186712265015 1.744480013847351 2.846071243286133 0.62665215676545 1.7776354551315308 -4.387406221001797 36.12667288766957 -2.8988061688512534 15.572186168852356 -6.946600741878115 102.32713407521254 DOWN 0.0 1.0 0.0 GO:0019853 6 L-ascorbic acid biosynthetic process 2 2 2 2 2 2 2 2 36 0 2509 1.0 2.1682E-4 2.1682E-4 100.0 25106;60671 rgn;gulo RGN_9699;GULO_8772 473.41200000000003 473.41200000000003 193.989 395.16379623897734 466.6381090909091 395.0476612535551 285.495 285.495 112.274 244.97148748782988 281.29570303030306 244.89949263304038 1517.3 1517.3 1039.83 675.2445496262816 1505.7249696969698 675.0461014974965 0.0 193.989 0.0 193.989 752.835;193.989 458.716;112.274 1994.77;1039.83 1 1 1 60671 GULO_8772 193.989 193.989 112.274 112.274 1039.83 1039.83 193.989 112.274 1039.83 1 25106 RGN_9699 752.835 752.835 458.716 458.716 1994.77 1994.77 752.835 458.716 1994.77 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.6490365989846616 3.300598978996277 1.5857495069503784 1.7148494720458984 0.0912874607699888 1.6502994894981384 -74.25707999999986 1021.0810799999999 -54.018159999999966 625.00816 581.4588000000001 2453.1412 CONFLICT 0.5 0.5 0.0 GO:0042364 6 water-soluble vitamin biosynthetic process 2 2 2 2 2 2 2 2 36 0 2509 1.0 2.1682E-4 2.1682E-4 100.0 25106;60671 rgn;gulo RGN_9699;GULO_8772 473.41200000000003 473.41200000000003 193.989 395.16379623897734 466.6381090909091 395.0476612535551 285.495 285.495 112.274 244.97148748782988 281.29570303030306 244.89949263304038 1517.3 1517.3 1039.83 675.2445496262816 1505.7249696969698 675.0461014974965 0.0 193.989 0.0 193.989 752.835;193.989 458.716;112.274 1994.77;1039.83 1 1 1 60671 GULO_8772 193.989 193.989 112.274 112.274 1039.83 1039.83 193.989 112.274 1039.83 1 25106 RGN_9699 752.835 752.835 458.716 458.716 1994.77 1994.77 752.835 458.716 1994.77 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.6490365989846616 3.300598978996277 1.5857495069503784 1.7148494720458984 0.0912874607699888 1.6502994894981384 -74.25707999999986 1021.0810799999999 -54.018159999999966 625.00816 581.4588000000001 2453.1412 CONFLICT 0.5 0.5 0.0 GO:0065003 6 protein-containing complex assembly 203 233 6 6 5 4 3 3 35 230 2279 0.5362 0.68998 1.0 1.29 25044;291885;361921 sds;mcm5;ect2 SDS_9798;MCM5_9209;ECT2_8523 199.13783333333333 31.2319 12.5006 307.1861946319258 324.8122692913386 322.2584948013564 134.54384333333334 16.4725 9.67503 210.41979752513453 220.5742828329339 220.89341638966465 379.6467 67.1945 36.0856 568.337072737183 612.1333244094488 596.3149795917067 553.681;12.5006;31.2319 377.484;9.67503;16.4725 1035.66;36.0856;67.1945 1 2 1 25044 SDS_9798 553.681 553.681 377.484 377.484 1035.66 1035.66 553.681 377.484 1035.66 2 291885;361921 MCM5_9209;ECT2_8523 21.86625 21.86625 13.24502925043957 13.073765 13.073765 4.8065371319121235 51.64005 51.64005 21.997314145254197 12.5006;31.2319 9.67503;16.4725 36.0856;67.1945 0 Exp 4,1(0.34);Exp 5,1(0.34);Linear,1(0.34) 1.8082526891176922 5.47559118270874 1.5452189445495605 2.1538212299346924 0.3072035388384963 1.7765510082244873 -148.47606970434168 546.7517363710083 -103.56857308483416 372.6562597515008 -263.4872413931028 1022.780641393103 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0006807 3 nitrogen compound metabolic process 1028 1128 33 30 20 18 11 11 27 1117 1392 0.037941 0.98302 0.069334 0.98 362246;360243;89829;25044;114519;291885;24450;24296;25612;25748;54223 tp53inp2;top2a;socs3;sds;nfil3;mcm5;hmgcs2;cyp1a1;asns;alas2;adcy4 TP53INP2_32755;TOP2A_10059;SOCS3_32863;SDS_9798;NFIL3_9304;MCM5_9209;HMGCS2_8812;CYP1A1_8415;ASNS_8091;ALAS2_8019;ADCY4_7988 311.92816363636365 121.321 12.3342 338.6007128098116 294.001832070979 335.01330346735006 189.72215454545457 82.5516 3.46407 202.28101518247408 177.66621490665054 198.7137354562218 823.5024727272728 229.79 36.0856 998.9247762043647 784.3767092242362 1003.9877018586928 827.265;12.3342;809.124;553.681;121.321;12.5006;106.351;49.0449;157.765;65.3911;716.432 495.492;3.46407;488.627;377.484;82.5516;9.67503;59.8697;39.2363;99.5663;37.2697;393.708 2498.6;46.5267;2346.74;1035.66;229.79;36.0856;208.329;64.8529;371.219;133.644;2087.08 4 7 4 89829;25044;24296;25612 SOCS3_32863;SDS_9798;CYP1A1_8415;ASNS_8091 392.403725 355.723 352.42813026322955 251.22839999999997 238.52515 216.2102486409468 954.617975 703.4395000000001 1012.6874797664227 809.124;553.681;49.0449;157.765 488.627;377.484;39.2363;99.5663 2346.74;1035.66;64.8529;371.219 7 362246;360243;114519;291885;24450;25748;54223 TP53INP2_32755;TOP2A_10059;NFIL3_9304;MCM5_9209;HMGCS2_8812;ALAS2_8019;ADCY4_7988 265.94212857142855 106.351 349.566253686025 154.57572857142856 59.8697 202.13712525968197 748.5793285714286 208.329 1064.098980958859 827.265;12.3342;121.321;12.5006;106.351;65.3911;716.432 495.492;3.46407;82.5516;9.67503;59.8697;37.2697;393.708 2498.6;46.5267;229.79;36.0856;208.329;133.644;2087.08 0 Exp 2,1(0.1);Exp 4,1(0.1);Exp 5,2(0.19);Hill,1(0.1);Linear,3(0.28);Poly 2,3(0.28) 2.15917596357109 28.005597710609436 1.5452189445495605 8.822484970092773 2.126333887714583 1.7404011487960815 111.82792949558365 512.0283977771435 70.18171363981793 309.2625954510912 233.17565401265028 1413.8292914418953 DOWN 0.36363636363636365 0.6363636363636364 0.0 GO:0002252 3 immune effector process 125 137 4 3 3 3 3 3 35 134 2375 0.8555 0.33546 0.45588 2.19 363328;499271;24253 ticam1;itgax;cebpb TICAM1_10015;ITGAX_32980;CEBPB_32843,CEBPB_8282 24253(-0.009836) 526.7456666666666 620.8109999999999 148.304 341.2742892195857 428.8166272930919 362.4544786695405 331.37399999999997 409.549 95.184 208.40559847326557 269.3064977296119 221.92604138778384 1327.9016666666666 1279.85 340.985 1011.7986263621497 1086.8157001876855 1046.0083212896202 811.122;148.304;620.8109999999999 489.389;95.184;409.549 2362.87;340.985;1279.85 0 4 0 3 363328;499271;24253 TICAM1_10015;ITGAX_32980;CEBPB_32843,CEBPB_8282 526.7456666666666 620.8109999999999 341.2742892195857 331.37399999999997 409.549 208.40559847326557 1327.9016666666666 1279.85 1011.7986263621497 811.122;148.304;620.8109999999999 489.389;95.184;409.549 2362.87;340.985;1279.85 0 Linear,3(0.75);Poly 2,1(0.25) 1.65711004946544 6.647575736045837 1.5415632724761963 1.8672927618026733 0.14807594990133566 1.6193598508834839 140.55745327975183 912.9338800535813 95.54086437683662 567.2071356231634 182.94373644674056 2472.859596886593 DOWN 0.0 1.0 0.0 GO:0046677 4 response to antibiotic 202 218 10 9 7 8 5 5 33 213 2296 0.89944 0.22132 0.37133 2.29 24314;24587;24450;361921;24296 nqo1;nefh;hmgcs2;ect2;cyp1a1 NQO1_33055;NEFH_33218;HMGCS2_8812;ECT2_8523;CYP1A1_8415 45.43578000000059 40.5511 2.95157E-12 38.77405764421533 58.931861099296846 37.5134825315019 27.43234000000059 21.5832 2.95157E-12 22.904036788805584 36.59994845738616 21.070401475164058 83.9463200000006 67.1945 2.95158E-12 76.13195168420994 105.54086151153308 78.30995177540223 40.5511;2.95157E-12;106.351;31.2319;49.0449 21.5832;2.95157E-12;59.8697;16.4725;39.2363 79.3552;2.95158E-12;208.329;67.1945;64.8529 2 3 2 24314;24296 NQO1_33055;CYP1A1_8415 44.798 44.798 6.006023578042245 30.409750000000003 30.409750000000003 12.482626718964237 72.10405 72.10405 10.254674672801642 40.5511;49.0449 21.5832;39.2363 79.3552;64.8529 3 24587;24450;361921 NEFH_33218;HMGCS2_8812;ECT2_8523 45.86096666666765 31.2319 54.66389113393958 25.447400000000982 16.4725 30.927445206966663 91.84116666666766 67.1945 106.32890808046069 2.95157E-12;106.351;31.2319 2.95157E-12;59.8697;16.4725 2.95158E-12;208.329;67.1945 0 Exp 4,3(0.6);Hill,1(0.2);Poly 2,1(0.2) 3.147553657033471 18.578669786453247 2.1538212299346924 8.822484970092773 2.860038706612489 2.578549861907959 11.448819966863951 79.42274003313723 7.356066578181881 47.5086134218193 17.213722063556375 150.6789179364448 DOWN 0.4 0.6 0.0 GO:0051186 4 cofactor metabolic process 111 126 7 7 6 6 5 5 33 121 2388 0.99026 0.037009 0.037009 3.97 25106;24450;60671;24296;25748 rgn;hmgcs2;gulo;cyp1a1;alas2 RGN_9699;HMGCS2_8812;GULO_8772;CYP1A1_8415;ALAS2_8019 233.52219999999997 106.351 49.0449 295.68611451081875 143.44103746631583 215.02672787655078 141.47314 59.8697 37.2697 179.9065533676942 87.81879113273942 129.98975084561616 688.2851800000001 208.329 64.8529 830.2317336709746 377.5908100973274 631.4071643890048 752.835;106.351;193.989;49.0449;65.3911 458.716;59.8697;112.274;39.2363;37.2697 1994.77;208.329;1039.83;64.8529;133.644 2 3 2 60671;24296 GULO_8772;CYP1A1_8415 121.51695000000001 121.51695000000001 102.49095600298105 75.75515 75.75515 51.64545295226869 552.34145 552.34145 689.4129189115946 193.989;49.0449 112.274;39.2363 1039.83;64.8529 3 25106;24450;25748 RGN_9699;HMGCS2_8812;ALAS2_8019 308.19236666666666 106.351 385.61604204856854 185.28513333333333 59.8697 237.06754129269433 778.9143333333333 208.329 1053.62384840622 752.835;106.351;65.3911 458.716;59.8697;37.2697 1994.77;208.329;133.644 0 Exp 2,1(0.2);Exp 4,1(0.2);Exp 5,1(0.2);Poly 2,2(0.4) 2.541252645601179 16.414849996566772 1.5857495069503784 8.822484970092773 3.121943315667682 1.7148494720458984 -25.658106803199246 492.70250680319924 -16.221906907720324 299.1681869077203 -39.44502067779365 1416.0153806777935 DOWN 0.4 0.6 0.0 GO:0051315 5 attachment of mitotic spindle microtubules to kinetochore 3 3 1 1 1 1 1 1 37 2 2507 0.99936 0.044111 0.044111 33.33 304951 nuf2 NUF2_33136 9.55312 9.55312 9.55312 9.55312 4.27871 4.27871 4.27871 4.27871 37.8054 37.8054 37.8054 37.8054 0.0 9.55312 0.0 9.55312 9.55312 4.27871 37.8054 0 1 0 1 304951 NUF2_33136 9.55312 9.55312 4.27871 4.27871 37.8054 37.8054 9.55312 4.27871 37.8054 0 Exp 5,1(1) 1.9102550745010376 1.9102550745010376 1.9102550745010376 1.9102550745010376 0.0 1.9102550745010376 9.55312 9.55312 4.27871 4.27871 37.8054 37.8054 DOWN 0.0 1.0 0.0 GO:0010212 5 response to ionizing radiation 75 76 5 5 5 3 3 3 35 73 2436 0.97493 0.10235 0.10235 3.95 360243;89829;361921 top2a;socs3;ect2 TOP2A_10059;SOCS3_32863;ECT2_8523 284.2300333333333 31.2319 12.3342 454.6697020350304 382.2437045558087 484.5175703771955 169.52119000000002 16.4725 3.46407 276.4302684124575 228.84410359197037 294.8660981020616 820.1537333333332 67.1945 46.5267 1322.1028748439599 1111.167870914009 1402.2911399963664 12.3342;809.124;31.2319 3.46407;488.627;16.4725 46.5267;2346.74;67.1945 1 2 1 89829 SOCS3_32863 809.124 809.124 488.627 488.627 2346.74 2346.74 809.124 488.627 2346.74 2 360243;361921 TOP2A_10059;ECT2_8523 21.78305 21.78305 13.362691818829017 9.968285 9.968285 9.198349065590524 56.860600000000005 56.860600000000005 14.614341532207316 12.3342;31.2319 3.46407;16.4725 46.5267;67.1945 0 Exp 4,1(0.34);Hill,1(0.34);Linear,1(0.34) 2.201413340584302 6.740293622016907 1.7404011487960815 2.846071243286133 0.5586639720982199 2.1538212299346924 -230.27716939675855 798.7372360634251 -143.289106164982 482.331486164982 -675.9465100142415 2316.253976680908 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0033554 4 cellular response to stress 394 417 19 18 14 12 9 9 29 408 2101 0.92066 0.15641 0.26518 2.16 360243;363140;338475;24314;24587;291885;361921;24253;25612 top2a;rassf1;nrep;nqo1;nefh;mcm5;ect2;cebpb;asns TOP2A_10059;RASSF1_32475;NREP_9364;NQO1_33055;NEFH_33218;MCM5_9209;ECT2_8523;CEBPB_32843,CEBPB_8282;ASNS_8091 24253(-0.009836) 210.35775555555585 40.5511 2.95157E-12 324.9901284292111 297.0867864432945 382.84194401073023 138.65617777777808 21.5832 2.95157E-12 218.51772421717035 197.19774980409537 258.6074911766192 361.7977777777781 79.3552 2.95158E-12 503.3211420399373 461.1451050803597 530.6146275605408 12.3342;903.848;114.178;40.5511;2.95157E-12;12.5006;31.2319;620.8109999999999;157.765 3.46407;608.514;79.0815;21.5832;2.95157E-12;9.67503;16.4725;409.549;99.5663 46.5267;1171.72;204.229;79.3552;2.95158E-12;36.0856;67.1945;1279.85;371.219 3 7 3 363140;24314;25612 RASSF1_32475;NQO1_33055;ASNS_8091 367.38803333333334 157.765 468.2699504188832 243.22116666666668 99.5663 318.7467357243417 540.7647333333333 371.219 565.5745139576335 903.848;40.5511;157.765 608.514;21.5832;99.5663 1171.72;79.3552;371.219 6 360243;338475;24587;291885;361921;24253 TOP2A_10059;NREP_9364;NEFH_33218;MCM5_9209;ECT2_8523;CEBPB_32843,CEBPB_8282 131.84261666666714 21.86625 243.07689690940498 86.37368333333382 13.073765 160.99611004652482 272.31430000000046 56.860600000000005 498.55331594616 12.3342;114.178;2.95157E-12;12.5006;31.2319;620.8109999999999 3.46407;79.0815;2.95157E-12;9.67503;16.4725;409.549 46.5267;204.229;2.95158E-12;36.0856;67.1945;1279.85 0 Exp 4,2(0.2);Exp 5,1(0.1);Hill,2(0.2);Linear,2(0.2);Poly 2,3(0.3) 2.044665490763296 20.965107560157776 1.5669527053833008 2.846071243286133 0.49671440592837574 1.9651861190795898 -1.969128351528724 422.68463946264046 -4.108735377439871 281.42109093299604 32.96129831168571 690.6342572438705 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0019538 4 protein metabolic process 588 639 19 17 9 8 3 3 35 636 1873 0.0066909 0.99851 0.012885 0.47 362246;89829;25748 tp53inp2;socs3;alas2 TP53INP2_32755;SOCS3_32863;ALAS2_8019 567.2600333333334 809.124 65.3911 434.7258833496154 547.5524961115455 442.1013607114831 340.4629 488.627 37.2697 262.5954482677299 328.630010179828 267.1200901666267 1659.6613333333335 2346.74 133.644 1323.7492364966006 1598.0134332030232 1344.4889295424148 827.265;809.124;65.3911 495.492;488.627;37.2697 2498.6;2346.74;133.644 1 2 1 89829 SOCS3_32863 809.124 809.124 488.627 488.627 2346.74 2346.74 809.124 488.627 2346.74 2 362246;25748 TP53INP2_32755;ALAS2_8019 446.32804999999996 446.32804999999996 538.7262010990416 266.38085 266.38085 324.0120956208965 1316.1219999999998 1316.1219999999998 1672.276424807813 827.265;65.3911 495.492;37.2697 2498.6;133.644 0 Exp 5,1(0.34);Linear,2(0.67) 1.6742321717259927 5.027547717094421 1.5739303827285767 1.7404011487960815 0.08930478995536588 1.7132161855697632 75.32138601316075 1059.198680653506 43.30817661912522 637.6176233808748 161.6980563928205 3157.6246102738464 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0042981 7 regulation of apoptotic process 428 455 14 14 12 10 8 8 30 447 2062 0.77377 0.36556 0.66834 1.76 360243;89829;25106;24314;24567;361921;24253;25612 top2a;socs3;rgn;nqo1;mt1;ect2;cebpb;asns TOP2A_10059;SOCS3_32863;RGN_9699;NQO1_33055;MT1A_9255;ECT2_8523;CEBPB_32843,CEBPB_8282;ASNS_8091 24253(-0.009836) 324.155025 163.17649999999998 12.3342 342.7452834326838 302.9412070559799 340.004261283162 200.19150875 101.56015 3.46407 213.03253686847742 185.9767535565327 210.25443992115652 924.325675 790.0845 46.5267 918.1992552317928 915.9987143871017 935.7458025522242 12.3342;809.124;752.835;40.5511;168.588;31.2319;620.8109999999999;157.765 3.46407;488.627;458.716;21.5832;103.554;16.4725;409.549;99.5663 46.5267;2346.74;1994.77;79.3552;1208.95;67.1945;1279.85;371.219 3 6 3 89829;24314;25612 SOCS3_32863;NQO1_33055;ASNS_8091 335.8133666666667 157.765 414.06761683099944 203.25883333333334 99.5663 250.1930931928844 932.4380666666666 371.219 1233.4843284008164 809.124;40.5511;157.765 488.627;21.5832;99.5663 2346.74;79.3552;371.219 5 360243;25106;24567;361921;24253 TOP2A_10059;RGN_9699;MT1A_9255;ECT2_8523;CEBPB_32843,CEBPB_8282 317.16002 168.588 345.963842520157 198.351114 103.554 219.3408898752179 919.4582399999999 1208.95 845.3321887021177 12.3342;752.835;168.588;31.2319;620.8109999999999 3.46407;458.716;103.554;16.4725;409.549 46.5267;1994.77;1208.95;67.1945;1279.85 0 Exp 2,1(0.12);Exp 4,2(0.23);Hill,1(0.12);Linear,3(0.34);Poly 2,2(0.23) 1.950748324718302 17.94169533252716 1.5669527053833008 2.846071243286133 0.4588180169624599 1.7404011487960815 86.6446611477432 561.6653888522567 52.56749234558791 347.81552515441206 288.0460535422585 1560.6052964577416 DOWN 0.375 0.625 0.0 GO:0072330 7 monocarboxylic acid biosynthetic process 51 55 4 4 3 4 3 3 35 52 2457 0.99167 0.047196 0.047196 5.45 25044;24296;25612 sds;cyp1a1;asns SDS_9798;CYP1A1_8415;ASNS_8091 253.49696666666668 157.765 49.0449 265.5896372925784 170.91034578520657 230.06936402125737 172.0955333333333 99.5663 39.2363 180.41131867142744 117.61045384828965 154.6426872993883 490.5773000000001 371.219 64.8529 496.2876274770206 324.94759761772553 443.51321487453527 1.5 355.723 553.681;49.0449;157.765 377.484;39.2363;99.5663 1035.66;64.8529;371.219 3 0 3 25044;24296;25612 SDS_9798;CYP1A1_8415;ASNS_8091 253.49696666666668 157.765 265.5896372925784 172.0955333333333 99.5663 180.41131867142744 490.5773000000001 371.219 496.2876274770206 553.681;49.0449;157.765 377.484;39.2363;99.5663 1035.66;64.8529;371.219 0 0 Linear,1(0.34);Poly 2,2(0.67) 2.793911499856857 11.967471837997437 1.5452189445495605 8.822484970092773 4.185873424086647 1.5997679233551025 -47.04600055962996 554.0399338929633 -32.05909253028247 376.2501591969491 -71.02501882590366 1052.1796188259036 UP 1.0 0.0 0.0 GO:0034645 5 cellular macromolecule biosynthetic process 143 162 4 4 4 2 2 2 36 160 2349 0.56102 0.70748 1.0 1.23 114519;25748 nfil3;alas2 NFIL3_9304;ALAS2_8019 93.35605 93.35605 65.3911 39.548411561085466 93.09174649424867 39.54664517147686 59.91065 59.91065 37.2697 32.01913855501112 59.696664905853915 32.01770845272915 181.71699999999998 181.71699999999998 133.644 67.98548858396192 181.26265045058247 67.98245208120906 121.321;65.3911 82.5516;37.2697 229.79;133.644 0 2 0 2 114519;25748 NFIL3_9304;ALAS2_8019 93.35605 93.35605 39.548411561085466 59.91065 59.91065 32.01913855501112 181.71699999999998 181.71699999999998 67.98548858396192 121.321;65.3911 82.5516;37.2697 229.79;133.644 0 Exp 5,1(0.5);Poly 2,1(0.5) 1.9229402764642831 3.8715540170669556 1.7132161855697632 2.1583378314971924 0.31474853428820254 1.9357770085334778 38.544748 148.167352 15.534388000000007 104.28691199999999 87.49391999999999 275.94007999999997 DOWN 0.0 1.0 0.0 GO:0031399 7 regulation of protein modification process 444 469 19 15 9 12 6 6 32 463 2046 0.43378 0.72689 0.83387 1.28 363328;89829;25106;363140;361921;60628 ticam1;socs3;rgn;rassf1;ect2;cxcr4 TICAM1_10015;SOCS3_32863;RGN_9699;RASSF1_32475;ECT2_8523;CXCR4_8411 551.3601500000003 780.9795 1.65461E-12 417.9209571482323 727.1485177200781 319.8476996798241 343.6197500000003 473.67150000000004 1.65461E-12 264.8742127946298 461.9195230820083 210.45815812899028 1323.8824166666668 1583.245 1.65462E-12 1089.1194202359266 1568.385202541408 885.1801804133148 811.122;809.124;752.835;903.848;31.2319;1.65461E-12 489.389;488.627;458.716;608.514;16.4725;1.65461E-12 2362.87;2346.74;1994.77;1171.72;67.1945;1.65462E-12 2 4 2 89829;363140 SOCS3_32863;RASSF1_32475 856.486 856.486 66.9799827411141 548.5705 548.5705 84.7729106761117 1759.23 1759.23 830.8646100298168 809.124;903.848 488.627;608.514 2346.74;1171.72 4 363328;25106;361921;60628 TICAM1_10015;RGN_9699;ECT2_8523;CXCR4_8411 398.7972250000004 392.03345 443.28243856327316 241.14437500000042 237.59425000000002 269.3144796557157 1106.2086250000004 1030.98225 1247.929886189215 811.122;752.835;31.2319;1.65461E-12 489.389;458.716;16.4725;1.65461E-12 2362.87;1994.77;67.1945;1.65462E-12 0 Exp 2,1(0.17);Exp 4,1(0.17);Hill,1(0.17);Linear,2(0.34);Poly 2,1(0.17) 1.8920875974124067 11.549323797225952 1.5415632724761963 2.6542086601257324 0.41035485101135 1.7424405813217163 216.95373804261737 885.7665619573833 131.67623865971697 555.5632613402836 452.40537947893813 2195.3594538543957 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0032787 7 monocarboxylic acid metabolic process 180 207 9 9 6 8 6 6 32 201 2308 0.96954 0.082803 0.12174 2.9 25044;266674;266684;29277;24296;25612 sds;cyp4a8;cyp2d1;cyp2c11;cyp1a1;asns SDS_9798;CYP4A8_32747;CYP2D1_32660;CYP2C11_32593;CYP1A1_8415;ASNS_8091 196.77325 142.256 49.0449 184.63934939259025 163.054722696881 169.63046138038237 133.1364 92.35974999999999 39.2363 124.6329343329603 111.01051804185191 113.69357364864909 367.35615000000007 309.7615 64.8529 351.15514828732745 305.0390564855976 326.0841537543604 553.681;76.6586;126.747;216.743;49.0449;157.765 377.484;57.8156;85.1532;139.563;39.2363;99.5663 1035.66;112.882;250.579;368.944;64.8529;371.219 5 1 5 25044;266674;266684;24296;25612 SDS_9798;CYP4A8_32747;CYP2D1_32660;CYP1A1_8415;ASNS_8091 192.7793 126.747 206.1430920638138 131.85108 85.1532 139.29938996380062 367.03858 250.579 392.6024278205397 553.681;76.6586;126.747;49.0449;157.765 377.484;57.8156;85.1532;39.2363;99.5663 1035.66;112.882;250.579;64.8529;371.219 1 29277 CYP2C11_32593 216.743 216.743 139.563 139.563 368.944 368.944 216.743 139.563 368.944 0 Exp 2,1(0.17);Linear,1(0.17);Poly 2,4(0.67) 2.7672715801309877 23.460757613182068 1.5452189445495605 8.822484970092773 3.626425632512746 1.5863355994224548 49.03100046590566 344.5154995340944 33.40928254122514 232.86351745877482 86.37351160726382 648.3387883927363 UP 0.8333333333333334 0.16666666666666666 0.0 GO:0009635 4 response to herbicide 15 16 2 2 2 2 2 2 36 14 2495 0.9985 0.022804 0.022804 12.5 24587;24296 nefh;cyp1a1 NEFH_33218;CYP1A1_8415 24.522450000001474 24.522450000001474 2.95157E-12 34.679981372614016 38.54581369895599 28.44980929880804 19.618150000001474 19.618150000001474 2.95157E-12 27.74425379866765 30.836949612219684 22.760067868235144 32.42645000000148 32.42645000000148 2.95158E-12 45.85792536961097 50.9697807771453 37.61966356287188 0.0 2.95157E-12 0.5 24.522450000001474 2.95157E-12;49.0449 2.95157E-12;39.2363 2.95158E-12;64.8529 1 1 1 24296 CYP1A1_8415 49.0449 49.0449 39.2363 39.2363 64.8529 64.8529 49.0449 39.2363 64.8529 1 24587 NEFH_33218 2.95157E-12 2.95157E-12 2.95157E-12 2.95157E-12 2.95158E-12 2.95158E-12 2.95157E-12 2.95157E-12 2.95158E-12 0 Hill,1(0.5);Poly 2,1(0.5) 4.64351133192548 11.26648998260498 2.444005012512207 8.822484970092773 4.5102664316677 5.63324499130249 -23.541551999995626 72.58645199999859 -18.83342399999563 58.06972399999859 -31.129391999995626 95.98229199999858 CONFLICT 0.5 0.5 0.0 GO:0043065 8 positive regulation of apoptotic process 196 210 5 5 5 3 3 3 35 207 2302 0.61618 0.61817 1.0 1.43 360243;24314;361921 top2a;nqo1;ect2 TOP2A_10059;NQO1_33055;ECT2_8523 28.039066666666667 31.2319 12.3342 14.376856399204007 28.05007484368764 16.466671077168034 13.839923333333333 16.4725 3.46407 9.342032055106287 13.633679690035919 10.600793027044686 64.3588 67.1945 46.5267 16.59694245727204 64.69356962884129 19.129327712321622 12.3342;40.5511;31.2319 3.46407;21.5832;16.4725 46.5267;79.3552;67.1945 1 2 1 24314 NQO1_33055 40.5511 40.5511 21.5832 21.5832 79.3552 79.3552 40.5511 21.5832 79.3552 2 360243;361921 TOP2A_10059;ECT2_8523 21.78305 21.78305 13.362691818829017 9.968285 9.968285 9.198349065590524 56.860600000000005 56.860600000000005 14.614341532207316 12.3342;31.2319 3.46407;16.4725 46.5267;67.1945 0 Exp 4,2(0.67);Hill,1(0.34) 2.510041923276443 7.57970118522644 2.1538212299346924 2.846071243286133 0.3491826531177494 2.5798087120056152 11.77012211879185 44.30801121454148 3.2684188786176307 24.411427788049036 45.577591576955726 83.14000842304428 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:1901362 5 organic cyclic compound biosynthetic process 212 234 8 8 7 5 5 5 33 229 2280 0.87018 0.2671 0.38959 2.14 114519;24450;24296;25748;54223 nfil3;hmgcs2;cyp1a1;alas2;adcy4 NFIL3_9304;HMGCS2_8812;CYP1A1_8415;ALAS2_8019;ADCY4_7988 211.708 106.351 49.0449 283.6741716834739 174.1975942777792 249.93865288639358 122.52706 59.8697 37.2697 152.70007573607487 102.31890488380013 134.5189830180549 544.7391799999999 208.329 64.8529 864.6487854875019 430.77229446642383 760.9222871504807 121.321;106.351;49.0449;65.3911;716.432 82.5516;59.8697;39.2363;37.2697;393.708 229.79;208.329;64.8529;133.644;2087.08 1 4 1 24296 CYP1A1_8415 49.0449 49.0449 39.2363 39.2363 64.8529 64.8529 49.0449 39.2363 64.8529 4 114519;24450;25748;54223 NFIL3_9304;HMGCS2_8812;ALAS2_8019;ADCY4_7988 252.373775 113.836 310.27409258815425 143.34975 71.21065 167.92613866666701 664.71075 219.0595 949.1411094273161 121.321;106.351;65.3911;716.432 82.5516;59.8697;37.2697;393.708 229.79;208.329;133.644;2087.08 0 Exp 2,1(0.2);Exp 4,1(0.2);Exp 5,1(0.2);Poly 2,2(0.4) 2.6824560413424003 16.923657059669495 1.6510682106018066 8.822484970092773 3.0627881461434887 2.1583378314971924 -36.94337468731581 460.35937468731584 -11.320457809970009 256.37457780997 -213.15889671697357 1302.6372567169738 DOWN 0.2 0.8 0.0 GO:0007610 2 behavior 142 151 3 3 2 3 2 2 36 149 2360 0.60616 0.66935 1.0 1.32 316351;24253 npas2;cebpb NPAS2_9350;CEBPB_32843,CEBPB_8282 24253(-0.009836) 387.91949999999997 387.91949999999997 155.028 329.3583178614135 323.0877934652278 316.3393766196019 253.791 253.791 98.033 220.27507604810847 210.43150879296562 211.567998933048 831.2724999999999 831.2724999999999 382.695 634.384384275417 706.3987075339728 609.308311877331 155.028;620.8109999999999 98.033;409.549 382.695;1279.85 0 3 0 2 316351;24253 NPAS2_9350;CEBPB_32843,CEBPB_8282 387.91949999999997 387.91949999999997 329.3583178614135 253.791 253.791 220.27507604810847 831.2724999999999 831.2724999999999 634.384384275417 155.028;620.8109999999999 98.033;409.549 382.695;1279.85 0 Linear,2(0.67);Poly 2,1(0.34) 1.5998529751664956 4.801898241043091 1.563178539276123 1.671766996383667 0.06163296323763625 1.5669527053833008 -68.54783999999984 844.3868399999998 -51.49467999999996 559.0766799999999 -47.939399999999864 1710.4843999999998 DOWN 0.0 1.0 0.0 GO:0090068 7 positive regulation of cell cycle process 80 86 9 8 7 4 3 3 35 83 2426 0.96268 0.13485 0.13485 3.49 315740;361921;24296 kif23;ect2;cyp1a1 KIF23_32798;ECT2_8523;CYP1A1_8415 30.204966666666667 31.2319 10.3381 19.373823463976677 34.149805225474914 22.109318832051358 19.981693333333336 16.4725 4.23628 17.76193059293199 25.252605043016338 20.21142812145511 51.25130000000001 64.8529 21.7065 25.613320322051184 49.96683941913506 25.365124044646855 10.3381;31.2319;49.0449 4.23628;16.4725;39.2363 21.7065;67.1945;64.8529 1 2 1 24296 CYP1A1_8415 49.0449 49.0449 39.2363 39.2363 64.8529 64.8529 49.0449 39.2363 64.8529 2 315740;361921 KIF23_32798;ECT2_8523 20.785 20.785 14.774147664755489 10.35439 10.35439 8.652314138090459 44.450500000000005 44.450500000000005 32.16487326261366 10.3381;31.2319 4.23628;16.4725 21.7065;67.1945 0 Exp 4,1(0.34);Exp 5,1(0.34);Poly 2,1(0.34) 3.118462124052568 12.572261929512024 1.595955729484558 8.822484970092773 4.020883295605109 2.1538212299346924 8.281421570034588 52.12851176329874 -0.11782326861386849 40.08120993528053 22.267099529758337 80.23550047024167 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0006732 5 coenzyme metabolic process 61 67 3 3 3 3 3 3 35 64 2445 0.98352 0.076344 0.076344 4.48 25106;24450;60671 rgn;hmgcs2;gulo RGN_9699;HMGCS2_8812;GULO_8772 351.0583333333334 193.989 106.351 350.6971231266851 243.63352951164845 300.8672827914195 210.28656666666666 112.274 59.8697 216.73587652800663 144.2410833457855 185.70122853081423 1080.9763333333333 1039.83 208.329 893.9309968785807 702.6841850845615 851.883887360373 752.835;106.351;193.989 458.716;59.8697;112.274 1994.77;208.329;1039.83 1 2 1 60671 GULO_8772 193.989 193.989 112.274 112.274 1039.83 1039.83 193.989 112.274 1039.83 2 25106;24450 RGN_9699;HMGCS2_8812 429.593 429.593 457.1332203286041 259.29285 259.29285 282.0269233811641 1101.5495 1101.5495 1263.2045452896768 752.835;106.351 458.716;59.8697 1994.77;208.329 0 Exp 2,1(0.34);Exp 4,1(0.34);Poly 2,1(0.34) 1.9140151645314385 5.879148840904236 1.5857495069503784 2.578549861907959 0.5397989917922285 1.7148494720458984 -45.79282041145592 747.9094870781225 -34.97316598006179 455.54629931339514 69.39818203112691 2092.5544846355397 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0032506 4 cytokinetic process 6 9 2 2 2 2 2 2 36 7 2502 0.99976 0.0073059 0.0073059 22.22 315740;361308 kif23;kif20a KIF23_32798;KIF20A_8961 22.806400000000004 22.806400000000004 10.3381 17.632838959736453 15.385928168271134 14.170046060935615 9.89114 9.89114 4.23628 7.997179705321121 6.525666812607148 6.4266681639150764 59.125299999999996 59.125299999999996 21.7065 52.918174447726365 36.85561196096532 42.525935335606086 0.0 10.3381 0.0 10.3381 10.3381;35.2747 4.23628;15.546 21.7065;96.5441 0 2 0 2 315740;361308 KIF23_32798;KIF20A_8961 22.806400000000004 22.806400000000004 17.632838959736453 9.89114 9.89114 7.997179705321121 59.125299999999996 59.125299999999996 52.918174447726365 10.3381;35.2747 4.23628;15.546 21.7065;96.5441 0 Exp 4,1(0.5);Exp 5,1(0.5) 1.6843477935248576 3.373591184616089 1.595955729484558 1.7776354551315308 0.1284669660090859 1.6867955923080444 -1.6314680000000017 47.244268000000005 -1.192385599999998 20.974665599999998 -14.215547999999991 132.466148 DOWN 0.0 1.0 0.0 GO:0051707 4 response to other organism 231 253 9 8 8 7 7 7 31 246 2263 0.97034 0.076201 0.094402 2.77 363328;89829;499271;24450;170568;24296;24253 ticam1;socs3;itgax;hmgcs2;dmbt1;cyp1a1;cebpb TICAM1_10015;SOCS3_32863;ITGAX_32980;HMGCS2_8812;DMBT1_32993;CYP1A1_8415;CEBPB_32843,CEBPB_8282 24253(-0.009836) 363.91480428571424 148.304 2.64673 366.6710536583471 282.4250764507486 344.02494498548793 226.1359385714286 95.184 1.09657 224.42933089411406 175.12219912807822 209.44224304274726 944.62374 340.985 8.73928 1052.4665657332632 731.891091822384 995.6900827133078 811.122;809.124;148.304;106.351;2.64673;49.0449;620.8109999999999 489.389;488.627;95.184;59.8697;1.09657;39.2363;409.549 2362.87;2346.74;340.985;208.329;8.73928;64.8529;1279.85 3 5 3 89829;170568;24296 SOCS3_32863;DMBT1_32993;CYP1A1_8415 286.93854333333337 49.0449 452.8205338878402 176.31995666666668 39.2363 271.13728393163603 806.7773933333333 64.8529 1333.9418304544138 809.124;2.64673;49.0449 488.627;1.09657;39.2363 2346.74;8.73928;64.8529 4 363328;499271;24450;24253 TICAM1_10015;ITGAX_32980;HMGCS2_8812;CEBPB_32843,CEBPB_8282 421.64699999999993 384.55749999999995 349.039175349511 263.497925 252.36649999999997 217.6784521864513 1048.0085 810.4175 997.9237007535529 811.122;148.304;106.351;620.8109999999999 489.389;95.184;59.8697;409.549 2362.87;340.985;208.329;1279.85 0 Exp 4,2(0.25);Linear,4(0.5);Poly 2,2(0.25) 2.170373779537914 21.4381422996521 1.5415632724761963 8.822484970092773 2.5042218743172753 1.7060840725898743 92.28108642083242 635.5485221505962 59.87636356418224 392.3955135786749 164.94559708068005 1724.3018829193197 CONFLICT 0.42857142857142855 0.5714285714285714 0.0 GO:0051240 5 positive regulation of multicellular organismal process 484 516 10 9 7 8 6 6 32 510 1999 0.32439 0.81229 0.68362 1.16 363328;316351;499271;361921;60628;24253 ticam1;npas2;itgax;ect2;cxcr4;cebpb TICAM1_10015;NPAS2_9350;ITGAX_32980;ECT2_8523;CXCR4_8411;CEBPB_32843,CEBPB_8282 24253(-0.009836) 294.41615000000024 151.666 1.65461E-12 337.7108731141697 304.0620797587384 312.40665361104794 184.77125000000026 96.60849999999999 1.65461E-12 210.39548187348242 190.96113865058274 193.01286784351316 738.9324166666669 361.84000000000003 1.65462E-12 917.8545957912077 767.5823423744056 868.3575471698205 811.122;155.028;148.304;31.2319;1.65461E-12;620.8109999999999 489.389;98.033;95.184;16.4725;1.65461E-12;409.549 2362.87;382.695;340.985;67.1945;1.65462E-12;1279.85 0 7 0 6 363328;316351;499271;361921;60628;24253 TICAM1_10015;NPAS2_9350;ITGAX_32980;ECT2_8523;CXCR4_8411;CEBPB_32843,CEBPB_8282 294.41615000000024 151.666 337.7108731141697 184.77125000000026 96.60849999999999 210.39548187348242 738.9324166666669 361.84000000000003 917.8545957912077 811.122;155.028;148.304;31.2319;1.65461E-12;620.8109999999999 489.389;98.033;95.184;16.4725;1.65461E-12;409.549 2362.87;382.695;340.985;67.1945;1.65462E-12;1279.85 0 Exp 4,1(0.15);Hill,1(0.15);Linear,3(0.43);Poly 2,2(0.29) 1.7186373044502532 12.109055519104004 1.5415632724761963 2.1538212299346924 0.2206039376283633 1.671766996383667 24.191172224960326 564.6411277750401 16.41980223950725 353.1226977604933 4.495780199392357 1473.3690531339414 DOWN 0.0 1.0 0.0 GO:0040016 4 embryonic cleavage 5 5 2 2 2 2 2 2 36 3 2506 0.99997 0.0021075 0.0021075 40.0 360243;361308 top2a;kif20a TOP2A_10059;KIF20A_8961 23.804450000000003 23.804450000000003 12.3342 16.22138311380999 16.87614086160196 12.92788981584313 9.505035 9.505035 3.46407 8.543214632821185 5.856145654585322 6.808651067009418 71.5354 71.5354 46.5267 35.36764271732003 56.42953877208822 28.186806568076193 0.0 12.3342 0.0 12.3342 12.3342;35.2747 3.46407;15.546 46.5267;96.5441 0 2 0 2 360243;361308 TOP2A_10059;KIF20A_8961 23.804450000000003 23.804450000000003 16.22138311380999 9.505035 9.505035 8.543214632821185 71.5354 71.5354 35.36764271732003 12.3342;35.2747 3.46407;15.546 46.5267;96.5441 0 Exp 4,1(0.5);Hill,1(0.5) 2.249283697067959 4.623706698417664 1.7776354551315308 2.846071243286133 0.7554981910665126 2.311853349208832 1.3227600000000024 46.28614 -2.3352564000000005 21.345326399999998 22.518348000000003 120.55245199999999 DOWN 0.0 1.0 0.0 GO:0048511 2 rhythmic process 111 122 5 5 4 5 4 4 34 118 2391 0.9672 0.10569 0.10569 3.28 360243;316351;114519;361308 top2a;npas2;nfil3;kif20a TOP2A_10059;NPAS2_9350;NFIL3_9304;KIF20A_8961 80.989475 78.29785 12.3342 68.09728954867317 92.90697255380199 69.43531062575197 49.8986675 49.0488 3.46407 47.326544966585345 58.85072282448589 47.62608193091256 188.88895 163.16705 46.5267 150.5858143543519 212.2897431420373 155.50782861566447 12.3342;155.028;121.321;35.2747 3.46407;98.033;82.5516;15.546 46.5267;382.695;229.79;96.5441 0 4 0 4 360243;316351;114519;361308 TOP2A_10059;NPAS2_9350;NFIL3_9304;KIF20A_8961 80.989475 78.29785 68.09728954867317 49.8986675 49.0488 47.326544966585345 188.88895 163.16705 150.5858143543519 12.3342;155.028;121.321;35.2747 3.46407;98.033;82.5516;15.546 46.5267;382.695;229.79;96.5441 0 Exp 4,1(0.25);Hill,1(0.25);Poly 2,2(0.5) 2.0326102885200705 8.345223069190979 1.563178539276123 2.846071243286133 0.5631375365121943 1.9679866433143616 14.254131242300275 147.7248187576997 3.518653432746362 96.27868156725364 41.314851932735166 336.4630480672648 DOWN 0.0 1.0 0.0 GO:0046951 5 ketone body biosynthetic process 1 1 1 1 1 1 1 1 37 0 2509 1.0 0.01492 0.01492 100.0 24450 hmgcs2 HMGCS2_8812 106.351 106.351 106.351 106.351 59.8697 59.8697 59.8697 59.8697 208.329 208.329 208.329 208.329 0.0 106.351 0.0 106.351 106.351 59.8697 208.329 0 1 0 1 24450 HMGCS2_8812 106.351 106.351 59.8697 59.8697 208.329 208.329 106.351 59.8697 208.329 0 Exp 4,1(1) 2.578549861907959 2.578549861907959 2.578549861907959 2.578549861907959 0.0 2.578549861907959 106.351 106.351 59.8697 59.8697 208.329 208.329 DOWN 0.0 1.0 0.0 GO:0032094 4 response to food 10 10 2 2 2 2 2 2 36 8 2501 0.99966 0.0090468 0.0090468 20.0 89829;24296 socs3;cyp1a1 SOCS3_32863;CYP1A1_8415 429.08445 429.08445 49.0449 537.457085848168 349.4476378965958 525.5245716847304 263.93165 263.93165 39.2363 317.76721137216947 216.84702060166856 310.71220763286505 1205.7964499999998 1205.7964499999998 64.8529 1613.5378423121053 966.7131569271054 1577.7143995413255 0.0 49.0449 0.0 49.0449 809.124;49.0449 488.627;39.2363 2346.74;64.8529 2 0 2 89829;24296 SOCS3_32863;CYP1A1_8415 429.08445 429.08445 537.457085848168 263.93165 263.93165 317.76721137216947 1205.7964499999998 1205.7964499999998 1613.5378423121053 809.124;49.0449 488.627;39.2363 2346.74;64.8529 0 0 Linear,1(0.5);Poly 2,1(0.5) 3.9185026447848195 10.562886118888855 1.7404011487960815 8.822484970092773 5.007789494970428 5.2814430594444275 -315.7930680000001 1173.961968 -176.47123599999998 704.334536 -1030.4529079999998 3442.0458079999994 UP 1.0 0.0 0.0 GO:0001889 6 liver development 91 101 6 6 6 6 6 6 32 95 2414 0.99943 0.003295 0.003295 5.94 25106;24450;24296;24253;25612;25748 rgn;hmgcs2;cyp1a1;cebpb;asns;alas2 RGN_9699;HMGCS2_8812;CYP1A1_8415;CEBPB_32843,CEBPB_8282;ASNS_8091;ALAS2_8019 24253(-0.009836) 292.03299999999996 132.058 49.0449 310.91764987315213 187.90478893959443 248.78185558950403 184.03449999999998 79.718 37.2697 195.63482091133983 118.80013564388517 157.29619371785236 675.44415 289.774 64.8529 785.2446386141168 413.3741898009883 615.536864098664 4.5 686.823 752.835;106.351;49.0449;620.8109999999999;157.765;65.3911 458.716;59.8697;39.2363;409.549;99.5663;37.2697 1994.77;208.329;64.8529;1279.85;371.219;133.644 2 5 2 24296;25612 CYP1A1_8415;ASNS_8091 103.40494999999999 103.40494999999999 76.87671996127956 69.40129999999999 69.40129999999999 42.65975210898442 218.03595 218.03595 216.6335468356759 49.0449;157.765 39.2363;99.5663 64.8529;371.219 4 25106;24450;24253;25748 RGN_9699;HMGCS2_8812;CEBPB_32843,CEBPB_8282;ALAS2_8019 386.347025 363.58099999999996 351.51921294139225 241.3511 234.70935 223.69827125568045 904.14825 744.0894999999999 896.000155220364 752.835;106.351;620.8109999999999;65.3911 458.716;59.8697;409.549;37.2697 1994.77;208.329;1279.85;133.644 0 Exp 2,1(0.15);Exp 4,1(0.15);Exp 5,1(0.15);Linear,2(0.29);Poly 2,2(0.29) 2.236728760312403 19.667588114738464 1.5669527053833008 8.822484970092773 2.6742985339454584 1.7132161855697632 43.24706588991771 540.8189341100823 27.49404086317338 340.5749591368267 47.11757863215098 1303.770721367849 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0061952 6 midbody abscission 2 2 1 1 1 1 1 1 37 1 2508 0.99978 0.029622 0.029622 50.0 361308 kif20a KIF20A_8961 35.2747 35.2747 35.2747 35.2747 15.546 15.546 15.546 15.546000000000001 96.5441 96.5441 96.5441 96.5441 0.0 35.2747 0.0 35.2747 35.2747 15.546 96.5441 0 1 0 1 361308 KIF20A_8961 35.2747 35.2747 15.546 15.546 96.5441 96.5441 35.2747 15.546 96.5441 0 Exp 4,1(1) 1.7776354551315308 1.7776354551315308 1.7776354551315308 1.7776354551315308 0.0 1.7776354551315308 35.2747 35.2747 15.546 15.546 96.5441 96.5441 DOWN 0.0 1.0 0.0 GO:0009066 8 aspartate family amino acid metabolic process 14 14 2 2 2 2 2 2 36 12 2497 0.999 0.01762 0.01762 14.29 25044;25612 sds;asns SDS_9798;ASNS_8091 355.723 355.723 157.765 279.95488838025324 320.7488677726879 275.5510110268024 238.52515 238.52515 99.5663 196.5174902817685 213.9746635632041 193.42613892149745 703.4395000000001 703.4395000000001 371.219 469.83073679837076 644.744606660889 462.4399855465796 0.0 157.765 0.5 355.723 553.681;157.765 377.484;99.5663 1035.66;371.219 2 0 2 25044;25612 SDS_9798;ASNS_8091 355.723 355.723 279.95488838025324 238.52515 238.52515 196.5174902817685 703.4395000000001 703.4395000000001 469.83073679837076 553.681;157.765 377.484;99.5663 1035.66;371.219 0 0 Linear,1(0.5);Poly 2,1(0.5) 1.5722568816993658 3.144986867904663 1.5452189445495605 1.5997679233551025 0.0385719528202 1.5724934339523315 -32.27467999999999 743.72068 -33.83419599999996 510.88449599999996 52.28732000000002 1354.59168 UP 1.0 0.0 0.0 GO:0016043 4 cellular component organization 805 877 31 30 19 19 12 12 26 865 1644 0.42713 0.70252 0.86365 1.37 24522;362246;360243;25044;304951;338475;24587;291885;315740;361308;361921;60628 zfp354a;tp53inp2;top2a;sds;nuf2;nrep;nefh;mcm5;kif23;kif20a;ect2;cxcr4 ZFP354A_10203;TP53INP2_32755;TOP2A_10059;SDS_9798;NUF2_33136;NREP_9364;NEFH_33218;MCM5_9209;KIF23_32798;KIF20A_8961;ECT2_8523;CXCR4_8411 142.13160166666705 21.86625 1.65461E-12 265.28224003430745 188.82650906695082 305.17989504780394 89.73222416666705 12.610515 1.65461E-12 166.0618265217847 118.08983637189525 187.92005185638638 350.657316666667 56.860600000000005 1.65462E-12 734.0871664480695 487.3257406079964 882.5466734855315 99.2226;827.265;12.3342;553.681;9.55312;114.178;2.95157E-12;12.5006;10.3381;35.2747;31.2319;1.65461E-12 71.0566;495.492;3.46407;377.484;4.27871;79.0815;2.95157E-12;9.67503;4.23628;15.546;16.4725;1.65461E-12 163.536;2498.6;46.5267;1035.66;37.8054;204.229;2.95158E-12;36.0856;21.7065;96.5441;67.1945;1.65462E-12 1 11 1 25044 SDS_9798 553.681 553.681 377.484 377.484 1035.66 1035.66 553.681 377.484 1035.66 11 24522;362246;360243;304951;338475;24587;291885;315740;361308;361921;60628 ZFP354A_10203;TP53INP2_32755;TOP2A_10059;NUF2_33136;NREP_9364;NEFH_33218;MCM5_9209;KIF23_32798;KIF20A_8961;ECT2_8523;CXCR4_8411 104.71802000000042 12.5006 242.76550235996854 63.57297181818224 9.67503 145.9497779005775 288.3843454545459 46.5267 735.9237609173931 99.2226;827.265;12.3342;9.55312;114.178;2.95157E-12;12.5006;10.3381;35.2747;31.2319;1.65461E-12 71.0566;495.492;3.46407;4.27871;79.0815;2.95157E-12;9.67503;4.23628;15.546;16.4725;1.65461E-12 163.536;2498.6;46.5267;37.8054;204.229;2.95158E-12;36.0856;21.7065;96.5441;67.1945;1.65462E-12 0 Exp 4,2(0.17);Exp 5,3(0.25);Hill,3(0.25);Linear,2(0.17);Poly 2,2(0.17) 1.8740253515067495 22.873648643493652 1.5452189445495605 2.846071243286133 0.39201465487869414 1.777093231678009 -7.965955574466591 292.22915890780075 -4.226099272916812 183.69054760625096 -64.69159802762664 766.0062313609608 DOWN 0.08333333333333333 0.9166666666666666 0.0 GO:0043523 7 regulation of neuron apoptotic process 110 113 3 3 3 3 3 3 35 110 2399 0.91486 0.23638 0.23638 2.65 24314;24567;24253 nqo1;mt1;cebpb NQO1_33055;MT1A_9255;CEBPB_32843,CEBPB_8282 24253(-0.009836) 276.6500333333333 168.588 40.5511 304.8498649714369 207.53298551175658 268.6200879227559 178.22873333333334 103.554 21.5832 204.478855486853 131.91581674734903 179.89920397209153 856.0517333333333 1208.95 79.3552 673.5724394369272 737.0256786076533 701.5162672169034 40.5511;168.588;620.8109999999999 21.5832;103.554;409.549 79.3552;1208.95;1279.85 1 3 1 24314 NQO1_33055 40.5511 40.5511 21.5832 21.5832 79.3552 79.3552 40.5511 21.5832 79.3552 2 24567;24253 MT1A_9255;CEBPB_32843,CEBPB_8282 394.69949999999994 394.69949999999994 319.7699499085241 256.5515 256.5515 216.37113950917762 1244.4 1244.4 50.13387078611953 168.588;620.8109999999999 103.554;409.549 1208.95;1279.85 0 Exp 4,1(0.25);Linear,2(0.5);Poly 2,1(0.25) 1.9335519865599253 7.886784315109253 1.5669527053833008 2.5798087120056152 0.459310870325104 1.8700114488601685 -68.3200638098798 621.6201304765465 -53.16087429415222 409.61834096081884 93.83276404719243 1618.2707026194744 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0008283 3 cell population proliferation 139 149 8 8 5 8 5 5 33 144 2365 0.9789 0.067603 0.067603 3.36 499271;170568;24296;60628;24253 itgax;dmbt1;cyp1a1;cxcr4;cebpb ITGAX_32980;DMBT1_32993;CYP1A1_8415;CXCR4_8411;CEBPB_32843,CEBPB_8282 24253(-0.009836) 164.16132600000032 49.0449 1.65461E-12 262.23466435728466 127.93883057070782 208.58420431785848 109.01317400000032 39.2363 1.65461E-12 172.41788366689454 85.7227558019291 136.6559985207839 338.8854360000003 64.8529 1.65462E-12 544.1397735678253 262.5300384638478 437.11520566049734 148.304;2.64673;49.0449;1.65461E-12;620.8109999999999 95.184;1.09657;39.2363;1.65461E-12;409.549 340.985;8.73928;64.8529;1.65462E-12;1279.85 2 4 2 170568;24296 DMBT1_32993;CYP1A1_8415 25.845814999999998 25.845814999999998 32.808460641646235 20.166435 20.166435 26.968861715624 36.79609000000001 36.79609000000001 39.67832121892507 2.64673;49.0449 1.09657;39.2363 8.73928;64.8529 3 499271;60628;24253 ITGAX_32980;CXCR4_8411;CEBPB_32843,CEBPB_8282 256.3716666666672 148.304 324.2075567662372 168.24433333333388 95.184 214.32674840143736 540.2783333333339 340.985 662.7913549212394 148.304;1.65461E-12;620.8109999999999 95.184;1.65461E-12;409.549 340.985;1.65462E-12;1279.85 0 Exp 4,1(0.17);Hill,1(0.17);Linear,2(0.34);Poly 2,2(0.34) 2.2335345255299184 17.322108030319214 1.5669527053833008 8.822484970092773 2.9095282574933448 1.708123505115509 -65.69749193941371 394.0201439394143 -42.117764499003826 260.14411249900445 -138.07410499992778 815.8449769999283 DOWN 0.4 0.6 0.0 GO:0046364 5 monosaccharide biosynthetic process 13 16 3 3 3 3 3 3 35 13 2496 0.99993 0.0015013 0.0015013 18.75 25044;25106;60671 sds;rgn;gulo SDS_9798;RGN_9699;GULO_8772 500.16833333333335 553.681 193.989 283.2400343336608 499.02955982092897 275.94458083620793 316.15799999999996 377.484 112.274 181.17994797438269 317.0904526021265 177.44097891885488 1356.7533333333333 1039.83 1035.66 552.5425752223388 1330.7987218802461 540.3932070468135 0.0 193.989 0.5 373.83500000000004 553.681;752.835;193.989 377.484;458.716;112.274 1035.66;1994.77;1039.83 2 1 2 25044;60671 SDS_9798;GULO_8772 373.83500000000004 373.83500000000004 254.34065233855173 244.879 244.879 187.53178943848425 1037.745 1037.745 2.9486352776779063 553.681;193.989 377.484;112.274 1035.66;1039.83 1 25106 RGN_9699 752.835 752.835 458.716 458.716 1994.77 1994.77 752.835 458.716 1994.77 0 Exp 2,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 1.6136779737193736 4.845817923545837 1.5452189445495605 1.7148494720458984 0.0885852163502061 1.5857495069503784 179.65206160041038 820.6846050662564 111.13358819984646 521.1824118001535 731.492548428375 1982.0141182382918 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0050727 6 regulation of inflammatory response 108 115 7 7 5 4 3 3 35 112 2397 0.91048 0.24445 0.24445 2.61 363328;89829;24253 ticam1;socs3;cebpb TICAM1_10015;SOCS3_32863;CEBPB_32843,CEBPB_8282 24253(-0.009836) 747.0189999999999 809.124 620.8109999999999 109.30389951415323 762.8902688572019 100.13382750845257 462.5216666666667 488.627 409.549 45.87725712521755 469.18870930633057 42.03214218477457 1996.4866666666665 2346.74 1279.85 620.6779585528512 2086.2654040090924 568.3723401434742 811.122;809.124;620.8109999999999 489.389;488.627;409.549 2362.87;2346.74;1279.85 1 3 1 89829 SOCS3_32863 809.124 809.124 488.627 488.627 2346.74 2346.74 809.124 488.627 2346.74 2 363328;24253 TICAM1_10015;CEBPB_32843,CEBPB_8282 715.9665 715.9665 134.57019863439257 449.469 449.469 56.455405409933775 1821.36 1821.36 765.8107861606546 811.122;620.8109999999999 489.389;409.549 2362.87;1279.85 0 Linear,4(1) 1.6282106382306885 6.520684123039246 1.5415632724761963 1.7404011487960815 0.09260812557929056 1.6193598508834839 623.329993816375 870.708006183625 410.6066630348515 514.4366702984819 1294.123437223578 2698.849896109755 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0003008 3 system process 296 309 4 4 4 3 3 3 35 306 2203 0.3052 0.8578 0.61573 0.97 60628;170945;24253 cxcr4;chrna2;cebpb CXCR4_8411;CHRNA2_32401;CEBPB_32843,CEBPB_8282 24253(-0.009836) 404.2806666666672 592.031 1.65461E-12 350.41292096658293 411.2622115203026 352.9447540308578 268.55133333333384 396.105 1.65461E-12 232.66939906299004 272.3286866315937 233.63399896710743 816.1600000000004 1168.63 1.65462E-12 708.9995284201526 838.3085174693111 720.6767376741714 1.65461E-12;592.031;620.8109999999999 1.65461E-12;396.105;409.549 1.65462E-12;1168.63;1279.85 0 4 0 3 60628;170945;24253 CXCR4_8411;CHRNA2_32401;CEBPB_32843,CEBPB_8282 404.2806666666672 592.031 350.41292096658293 268.55133333333384 396.105 232.66939906299004 816.1600000000004 1168.63 708.9995284201526 1.65461E-12;592.031;620.8109999999999 1.65461E-12;396.105;409.549 1.65462E-12;1168.63;1279.85 0 Hill,1(0.25);Linear,3(0.75) 1.7104815617203026 6.856364369392395 1.5669527053833008 1.8731646537780762 0.12867131059889714 1.708123505115509 7.751117941410996 800.8102153919233 5.261122578170671 531.8415440884971 13.8515055661627 1618.4684944338387 DOWN 0.0 1.0 0.0 GO:0071222 6 cellular response to lipopolysaccharide 81 86 5 5 4 4 3 3 35 83 2426 0.96268 0.13485 0.13485 3.49 363328;24450;24253 ticam1;hmgcs2;cebpb TICAM1_10015;HMGCS2_8812;CEBPB_32843,CEBPB_8282 24253(-0.009836) 512.7613333333333 620.8109999999999 106.351 364.59784483775167 396.31504877479574 386.6244067676527 319.6025666666667 409.549 59.8697 228.45016506924065 244.20162421820305 242.8397717418515 1283.683 1279.85 208.329 1077.275614263592 989.1758720536754 1114.557436887049 811.122;106.351;620.8109999999999 489.389;59.8697;409.549 2362.87;208.329;1279.85 0 4 0 3 363328;24450;24253 TICAM1_10015;HMGCS2_8812;CEBPB_32843,CEBPB_8282 512.7613333333333 620.8109999999999 364.59784483775167 319.6025666666667 409.549 228.45016506924065 1283.683 1279.85 1077.275614263592 811.122;106.351;620.8109999999999 489.389;59.8697;409.549 2362.87;208.329;1279.85 0 Exp 4,1(0.25);Linear,3(0.75) 1.7963548509786278 7.358832836151123 1.5415632724761963 2.578549861907959 0.49577454785241226 1.6193598508834839 100.18003216178784 925.3426345048787 61.08686864035121 578.1182646929822 64.63088286245124 2502.7351171375485 DOWN 0.0 1.0 0.0 GO:0042745 5 circadian sleep/wake cycle 2 2 1 1 1 1 1 1 37 1 2508 0.99978 0.029622 0.029622 50.0 316351 npas2 NPAS2_9350 155.028 155.028 155.028 155.028 98.033 98.033 98.033 98.033 382.695 382.695 382.695 382.695 0.0 155.028 0.0 155.028 155.028 98.033 382.695 0 1 0 1 316351 NPAS2_9350 155.028 155.028 98.033 98.033 382.695 382.695 155.028 98.033 382.695 0 Poly 2,1(1) 1.563178539276123 1.563178539276123 1.563178539276123 1.563178539276123 0.0 1.563178539276123 155.028 155.028 98.033 98.033 382.695 382.695 DOWN 0.0 1.0 0.0 GO:0007017 3 microtubule-based process 97 110 15 15 10 8 4 4 34 106 2403 0.97795 0.078781 0.078781 3.64 304951;24587;315740;361308 nuf2;nefh;kif23;kif20a NUF2_33136;NEFH_33218;KIF23_32798;KIF20A_8961 13.791480000000739 9.94561 2.95157E-12 15.073411370939656 11.0553661187818 11.614825321046338 6.015247500000738 4.2574950000000005 2.95157E-12 6.66330082260135 4.725141088963973 5.133765558439261 39.014000000000735 29.75595 2.95158E-12 41.363489827865386 28.86284222694289 32.58976829562219 9.55312;2.95157E-12;10.3381;35.2747 4.27871;2.95157E-12;4.23628;15.546 37.8054;2.95158E-12;21.7065;96.5441 0 4 0 4 304951;24587;315740;361308 NUF2_33136;NEFH_33218;KIF23_32798;KIF20A_8961 13.791480000000739 9.94561 15.073411370939656 6.015247500000738 4.2574950000000005 6.66330082260135 39.014000000000735 29.75595 41.363489827865386 9.55312;2.95157E-12;10.3381;35.2747 4.27871;2.95157E-12;4.23628;15.546 37.8054;2.95158E-12;21.7065;96.5441 0 Exp 4,1(0.25);Exp 5,2(0.5);Hill,1(0.25) 1.907718316798982 7.7278512716293335 1.595955729484558 2.444005012512207 0.3648635057804739 1.8439452648162842 -0.9804631435201241 28.563423143521604 -0.5147873061485857 12.545282306150062 -1.5222200313073415 79.55022003130881 DOWN 0.0 1.0 0.0 GO:0006267 8 pre-replicative complex assembly involved in nuclear cell cycle DNA replication 5 5 1 1 1 1 1 1 37 4 2505 0.99789 0.07246 0.07246 20.0 291885 mcm5 MCM5_9209 12.5006 12.5006 12.5006 12.5006 9.67503 9.67503 9.67503 9.67503 36.0856 36.0856 36.0856 36.0856 0.0 12.5006 0.0 12.5006 12.5006 9.67503 36.0856 0 1 0 1 291885 MCM5_9209 12.5006 12.5006 9.67503 9.67503 36.0856 36.0856 12.5006 9.67503 36.0856 0 Exp 5,1(1) 1.7765510082244873 1.7765510082244873 1.7765510082244873 1.7765510082244873 0.0 1.7765510082244873 12.5006 12.5006 9.67503 9.67503 36.0856 36.0856 DOWN 0.0 1.0 0.0 GO:0036388 8 pre-replicative complex assembly 5 5 1 1 1 1 1 1 37 4 2505 0.99789 0.07246 0.07246 20.0 291885 mcm5 MCM5_9209 12.5006 12.5006 12.5006 12.5006 9.67503 9.67503 9.67503 9.67503 36.0856 36.0856 36.0856 36.0856 0.0 12.5006 0.0 12.5006 12.5006 9.67503 36.0856 0 1 0 1 291885 MCM5_9209 12.5006 12.5006 9.67503 9.67503 36.0856 36.0856 12.5006 9.67503 36.0856 0 Exp 5,1(1) 1.7765510082244873 1.7765510082244873 1.7765510082244873 1.7765510082244873 0.0 1.7765510082244873 12.5006 12.5006 9.67503 9.67503 36.0856 36.0856 DOWN 0.0 1.0 0.0 GO:0044087 5 regulation of cellular component biogenesis 211 228 4 4 3 3 2 2 36 226 2283 0.32478 0.86776 0.57441 0.88 363328;361921 ticam1;ect2 TICAM1_10015;ECT2_8523 421.17695 421.17695 31.2319 551.4655782902546 629.5631511466296 466.11658024828716 252.93075000000002 252.93075000000002 16.4725 334.4024640850079 379.29377588603194 282.64780091834615 1215.03225 1215.03225 67.1945 1623.287713453818 1828.4354673384294 1372.0553875729104 811.122;31.2319 489.389;16.4725 2362.87;67.1945 0 2 0 2 363328;361921 TICAM1_10015;ECT2_8523 421.17695 421.17695 551.4655782902546 252.93075000000002 252.93075000000002 334.4024640850079 1215.03225 1215.03225 1623.287713453818 811.122;31.2319 489.389;16.4725 2362.87;67.1945 0 Exp 4,1(0.5);Linear,1(0.5) 1.8221557846536698 3.6953845024108887 1.5415632724761963 2.1538212299346924 0.43293175355432734 1.8476922512054443 -343.1153480000001 1185.469248 -210.52741999999998 716.38892 -1034.72974 3464.79424 DOWN 0.0 1.0 0.0 GO:0051246 6 regulation of protein metabolic process 635 675 26 22 16 16 10 10 28 665 1844 0.57393 0.57275 1.0 1.48 360772;363328;89829;299276;25106;363140;83928;361921;60628;24253 zfand2a;ticam1;socs3;serpina3m;rgn;rassf1;fetub;ect2;cxcr4;cebpb ZFAND2A_10197;TICAM1_10015;SOCS3_32863;SERPINA3M_9809;RGN_9699;RASSF1_32475;FETUB_33027;ECT2_8523;CXCR4_8411;CEBPB_32843,CEBPB_8282 24253(-0.009836) 588.7769900000001 686.823 1.65461E-12 337.8120363494414 684.6121892945629 267.4096804441208 383.7174500000002 434.1325 1.65461E-12 226.35654693799233 451.30198302187586 185.5598800128734 1241.0585500000002 1225.7849999999999 1.65462E-12 826.6390047940596 1338.3510678740856 677.7214889566754 946.037;811.122;809.124;466.86;752.835;903.848;545.901;31.2319;1.65461E-12;620.8109999999999 687.617;489.389;488.627;296.126;458.716;608.514;382.164;16.4725;1.65461E-12;409.549 1292.08;2362.87;2346.74;918.743;1994.77;1171.72;976.618;67.1945;1.65462E-12;1279.85 4 7 4 360772;89829;363140;83928 ZFAND2A_10197;SOCS3_32863;RASSF1_32475;FETUB_33027 801.2275 856.486 179.58724400227734 541.7304999999999 548.5705 134.19433220644422 1446.7894999999999 1231.9 613.8866347795823 946.037;809.124;903.848;545.901 687.617;488.627;608.514;382.164 1292.08;2346.74;1171.72;976.618 6 363328;299276;25106;361921;60628;24253 TICAM1_10015;SERPINA3M_9809;RGN_9699;ECT2_8523;CXCR4_8411;CEBPB_32843,CEBPB_8282 447.143316666667 543.8354999999999 354.79474380819306 278.375416666667 352.8375 219.38872390540368 1103.9045833333337 1099.2965 973.3704164965363 811.122;466.86;752.835;31.2319;1.65461E-12;620.8109999999999 489.389;296.126;458.716;16.4725;1.65461E-12;409.549 2362.87;918.743;1994.77;67.1945;1.65462E-12;1279.85 0 Exp 2,3(0.28);Exp 4,1(0.1);Hill,1(0.1);Linear,4(0.37);Poly 2,2(0.19) 1.8229895599665604 20.44656276702881 1.5054508447647095 2.6542086601257324 0.4079312253957509 1.7148494720458984 379.39892064676997 798.1550593532302 243.42020868348604 524.0146913165144 728.7023866547212 1753.4147133452793 DOWN 0.4 0.6 0.0 GO:0007051 6 spindle organization 29 29 6 6 4 4 2 2 36 27 2482 0.99143 0.06837 0.06837 6.9 304951;361308 nuf2;kif20a NUF2_33136;KIF20A_8961 22.41391 22.41391 9.55312 18.187903640832282 20.872680005733944 18.056828599113125 9.912355 9.912355 4.27871 7.967177164595375 9.237222084288991 7.909759987780735 67.17475 67.17475 37.8054 41.534533088082235 63.65514326261468 41.23520553693533 0.5 22.41391 9.55312;35.2747 4.27871;15.546 37.8054;96.5441 0 2 0 2 304951;361308 NUF2_33136;KIF20A_8961 22.41391 22.41391 18.187903640832282 9.912355 9.912355 7.967177164595375 67.17475 67.17475 41.534533088082235 9.55312;35.2747 4.27871;15.546 37.8054;96.5441 0 Exp 4,1(0.5);Exp 5,1(0.5) 1.8427526010775206 3.6878905296325684 1.7776354551315308 1.9102550745010376 0.09377623217455709 1.8439452648162842 -2.7932383999999963 47.621058399999995 -1.129589199999998 20.954299199999998 9.610824000000001 124.738676 DOWN 0.0 1.0 0.0 GO:0009888 4 tissue development 153 164 4 4 4 2 2 2 36 162 2347 0.55293 0.71402 1.0 1.22 24450;170568 hmgcs2;dmbt1 HMGCS2_8812;DMBT1_32993 54.498865 54.498865 2.64673 73.32999255500064 61.8830978394133 72.58260135089616 30.483135 30.483135 1.09657 41.55887877455851 34.668058886172744 41.13530392658272 108.53414000000001 108.53414000000001 8.73928 141.13124446712428 122.74586884041618 139.69281188225892 106.351;2.64673 59.8697;1.09657 208.329;8.73928 1 1 1 170568 DMBT1_32993 2.64673 2.64673 1.09657 1.09657 8.73928 8.73928 2.64673 1.09657 8.73928 1 24450 HMGCS2_8812 106.351 106.351 59.8697 59.8697 208.329 208.329 106.351 59.8697 208.329 0 Exp 4,2(1) 2.0621264356414946 4.227680444717407 1.6491305828094482 2.578549861907959 0.6571986748160694 2.1138402223587036 -47.13131959999999 156.1290496 -27.114532400000005 88.08080240000001 -87.06378560000002 304.13206560000003 CONFLICT 0.5 0.5 0.0 GO:0033693 7 neurofilament bundle assembly 2 2 1 1 1 1 1 1 37 1 2508 0.99978 0.029622 0.029622 50.0 24587 nefh NEFH_33218 2.95157E-12 2.95157E-12 2.95157E-12 2.95157E-12 2.95157E-12 2.95157E-12 2.95157E-12 2.95157E-12 2.95158E-12 2.95158E-12 2.95158E-12 2.95158E-12 0.0 2.95157E-12 0.0 2.95157E-12 2.95157E-12 2.95157E-12 2.95158E-12 0 1 0 1 24587 NEFH_33218 2.95157E-12 2.95157E-12 2.95157E-12 2.95157E-12 2.95158E-12 2.95158E-12 2.95157E-12 2.95157E-12 2.95158E-12 0 Hill,1(1) 2.444005012512207 2.444005012512207 2.444005012512207 2.444005012512207 0.0 2.444005012512207 2.95157E-12 2.95157E-12 2.95157E-12 2.95157E-12 2.95158E-12 2.95158E-12 DOWN 0.0 1.0 0.0 GO:0007165 4 signal transduction 714 752 19 18 14 13 10 10 28 742 1767 0.40725 0.72577 0.72395 1.33 363328;89829;363140;24567;499271;361921;60628;170945;24253;54223 ticam1;socs3;rassf1;mt1;itgax;ect2;cxcr4;chrna2;cebpb;adcy4 TICAM1_10015;SOCS3_32863;RASSF1_32475;MT1A_9255;ITGAX_32980;ECT2_8523;CXCR4_8411;CHRNA2_32401;CEBPB_32843,CEBPB_8282;ADCY4_7988 24253(-0.009836) 480.1491900000001 606.4209999999999 1.65461E-12 353.5035033349973 543.8124140456787 351.1455871702521 300.1102500000002 394.90650000000005 1.65461E-12 223.00371616575364 341.13913105946284 225.17689412307763 1203.4019500000002 1190.335 1.65462E-12 877.0828853279753 1315.1014498440486 814.6799421248325 811.122;809.124;903.848;168.588;148.304;31.2319;1.65461E-12;592.031;620.8109999999999;716.432 489.389;488.627;608.514;103.554;95.184;16.4725;1.65461E-12;396.105;409.549;393.708 2362.87;2346.74;1171.72;1208.95;340.985;67.1945;1.65462E-12;1168.63;1279.85;2087.08 2 9 2 89829;363140 SOCS3_32863;RASSF1_32475 856.486 856.486 66.9799827411141 548.5705 548.5705 84.7729106761117 1759.23 1759.23 830.8646100298168 809.124;903.848 488.627;608.514 2346.74;1171.72 8 363328;24567;499271;361921;60628;170945;24253;54223 TICAM1_10015;MT1A_9255;ITGAX_32980;ECT2_8523;CXCR4_8411;CHRNA2_32401;CEBPB_32843,CEBPB_8282;ADCY4_7988 386.0649875000002 380.30949999999996 330.8263975779026 237.9951875000002 248.63100000000003 202.1520753061092 1064.4449375000004 1188.79 883.2384758457457 811.122;168.588;148.304;31.2319;1.65461E-12;592.031;620.8109999999999;716.432 489.389;103.554;95.184;16.4725;1.65461E-12;396.105;409.549;393.708 2362.87;1208.95;340.985;67.1945;1.65462E-12;1168.63;1279.85;2087.08 0 Exp 2,1(0.1);Exp 4,1(0.1);Hill,1(0.1);Linear,5(0.46);Poly 2,3(0.28) 1.843784100259961 20.532975554466248 1.5415632724761963 2.6542086601257324 0.32468796848102077 1.744480013847351 261.0454486480463 699.2529313519541 161.89111472596366 438.3293852740368 659.7803455798186 1747.0235544201819 DOWN 0.2 0.8 0.0 GO:1903046 3 meiotic cell cycle process 29 29 8 8 4 6 3 3 35 26 2483 0.99923 0.0085695 0.0085695 10.34 360243;304951;361308 top2a;nuf2;kif20a TOP2A_10059;NUF2_33136;KIF20A_8961 19.054006666666666 12.3342 9.55312 14.116188247970252 15.402633779105708 10.632721213181789 7.762926666666666 4.27871 3.46407 6.75263522385397 5.538740767566454 5.3265634501399415 60.29206666666666 46.5267 37.8054 31.6965725122344 52.68206885431692 23.655824125147664 0.5 10.94366 1.5 23.804450000000003 12.3342;9.55312;35.2747 3.46407;4.27871;15.546 46.5267;37.8054;96.5441 0 3 0 3 360243;304951;361308 TOP2A_10059;NUF2_33136;KIF20A_8961 19.054006666666666 12.3342 14.116188247970252 7.762926666666666 4.27871 6.75263522385397 60.29206666666666 46.5267 31.6965725122344 12.3342;9.55312;35.2747 3.46407;4.27871;15.546 46.5267;37.8054;96.5441 0 Exp 4,1(0.34);Exp 5,1(0.34);Hill,1(0.34) 2.1300670663634897 6.533961772918701 1.7776354551315308 2.846071243286133 0.5823651344032185 1.9102550745010376 3.08003590026844 35.02797743306489 0.12160056877304903 15.404252764560285 24.4240183089057 96.16011502442764 DOWN 0.0 1.0 0.0 GO:0006974 5 cellular response to DNA damage stimulus 142 151 9 8 6 4 3 3 35 148 2361 0.81482 0.39384 0.49017 1.99 360243;363140;291885 top2a;rassf1;mcm5 TOP2A_10059;RASSF1_32475;MCM5_9209 309.5609333333333 12.5006 12.3342 514.6677035988301 520.6048481455645 540.5290419360009 207.2177 9.67503 3.46407 347.546664926162 348.8329203331008 366.26070330785797 418.1107666666667 46.5267 36.0856 652.6656200277777 687.2941409022206 683.2447800095463 12.3342;903.848;12.5006 3.46407;608.514;9.67503 46.5267;1171.72;36.0856 1 2 1 363140 RASSF1_32475 903.848 903.848 608.514 608.514 1171.72 1171.72 903.848 608.514 1171.72 2 360243;291885 TOP2A_10059;MCM5_9209 12.4174 12.4174 0.11766256838939407 6.56955 6.56955 4.391811933678399 41.30615 41.30615 7.382972613046798 12.3342;12.5006 3.46407;9.67503 46.5267;36.0856 0 Exp 5,1(0.34);Hill,1(0.34);Poly 2,1(0.34) 2.3763997800093146 7.2768309116363525 1.7765510082244873 2.846071243286133 0.5702291553934123 2.6542086601257324 -272.8403996100093 891.9622662766759 -186.0683746801095 600.5037746801095 -320.44990930448216 1156.6714426378155 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0009605 3 response to external stimulus 571 616 21 19 17 14 12 12 26 604 1905 0.89417 0.18693 0.33839 1.95 24522;363328;89829;25044;24314;499271;24450;170568;24296;60628;24253;25612 zfp354a;ticam1;socs3;sds;nqo1;itgax;hmgcs2;dmbt1;cyp1a1;cxcr4;cebpb;asns ZFP354A_10203;TICAM1_10015;SOCS3_32863;SDS_9798;NQO1_33055;ITGAX_32980;HMGCS2_8812;DMBT1_32993;CYP1A1_8415;CXCR4_8411;CEBPB_32843,CEBPB_8282;ASNS_8091 24253(-0.009836) 283.21861083333346 127.3275 1.65461E-12 318.249822648428 243.75852786005572 303.97514788169565 179.38680583333348 83.1203 1.65461E-12 198.1597992394939 152.89161746316884 187.6573933159149 688.511365 274.65700000000004 1.65462E-12 876.3132980085793 603.5942852385054 855.3553273076452 99.2226;811.122;809.124;553.681;40.5511;148.304;106.351;2.64673;49.0449;1.65461E-12;620.8109999999999;157.765 71.0566;489.389;488.627;377.484;21.5832;95.184;59.8697;1.09657;39.2363;1.65461E-12;409.549;99.5663 163.536;2362.87;2346.74;1035.66;79.3552;340.985;208.329;8.73928;64.8529;1.65462E-12;1279.85;371.219 6 7 6 89829;25044;24314;170568;24296;25612 SOCS3_32863;SDS_9798;NQO1_33055;DMBT1_32993;CYP1A1_8415;ASNS_8091 268.80212166666666 103.40494999999999 333.6655234793982 171.26556166666668 69.40129999999999 208.41263494730453 651.0943966666666 225.2871 914.8354879820726 809.124;553.681;40.5511;2.64673;49.0449;157.765 488.627;377.484;21.5832;1.09657;39.2363;99.5663 2346.74;1035.66;79.3552;8.73928;64.8529;371.219 6 24522;363328;499271;24450;60628;24253 ZFP354A_10203;TICAM1_10015;ITGAX_32980;HMGCS2_8812;CXCR4_8411;CEBPB_32843,CEBPB_8282 297.63510000000025 127.3275 333.15312277110615 187.50805000000028 83.1203 206.8670003025298 725.9283333333336 274.65700000000004 921.4938691435044 99.2226;811.122;148.304;106.351;1.65461E-12;620.8109999999999 71.0566;489.389;95.184;59.8697;1.65461E-12;409.549 163.536;2362.87;340.985;208.329;1.65462E-12;1279.85 0 Exp 4,3(0.24);Hill,1(0.08);Linear,5(0.39);Poly 2,4(0.31) 2.0315919894092445 30.74098837375641 1.5415632724761963 8.822484970092773 1.971922612858258 1.7404011487960815 103.15182247322537 463.28539919344166 67.26734466851913 291.50626699814785 192.6904408702921 1184.332289129708 CONFLICT 0.5 0.5 0.0 GO:0051094 5 positive regulation of developmental process 376 396 10 10 8 7 6 6 32 390 2119 0.62307 0.55308 1.0 1.52 89829;499271;361921;170568;60628;24253 socs3;itgax;ect2;dmbt1;cxcr4;cebpb SOCS3_32863;ITGAX_32980;ECT2_8523;DMBT1_32993;CXCR4_8411;CEBPB_32843,CEBPB_8282 24253(-0.009836) 268.6862716666669 89.76795 1.65461E-12 354.93959564339934 301.66790821711015 360.8877668371471 168.48817833333362 55.82825 1.65461E-12 221.58053645548543 187.86613311321094 222.16968754166848 673.9181300000002 204.08975 1.65462E-12 953.0029402382747 783.837240918832 1007.3771076340761 809.124;148.304;31.2319;2.64673;1.65461E-12;620.8109999999999 488.627;95.184;16.4725;1.09657;1.65461E-12;409.549 2346.74;340.985;67.1945;8.73928;1.65462E-12;1279.85 2 5 2 89829;170568 SOCS3_32863;DMBT1_32993 405.88536500000004 405.88536500000004 570.2655464898143 244.861785 244.861785 344.73607308779344 1177.7396399999998 1177.7396399999998 1653.2161635310308 809.124;2.64673 488.627;1.09657 2346.74;8.73928 4 499271;361921;60628;24253 ITGAX_32980;ECT2_8523;CXCR4_8411;CEBPB_32843,CEBPB_8282 200.0867250000004 89.76795 287.655474268384 130.3013750000004 55.82825 190.74234559188918 422.00737500000037 204.08975 590.604491273612 148.304;31.2319;1.65461E-12;620.8109999999999 95.184;16.4725;1.65461E-12;409.549 340.985;67.1945;1.65462E-12;1279.85 0 Exp 4,2(0.29);Hill,1(0.15);Linear,3(0.43);Poly 2,1(0.15) 1.762105941061611 12.393845438957214 1.5669527053833008 2.1538212299346924 0.19313087536279677 1.7404011487960815 -15.324555286464204 552.697098619798 -8.813177074380889 345.7895337410481 -88.64303947224869 1436.4792994722493 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0009404 4 toxin metabolic process 12 17 2 2 2 2 2 2 36 15 2494 0.9982 0.025604 0.025604 11.76 24296;26760 cyp1a1;akr7a3 CYP1A1_8415;AKR7A3_8015 55.92005 55.92005 49.0449 9.722930373349357 54.57399414208309 9.534759687571292 43.99265 43.99265 39.2363 6.726494677393277 43.06142482239615 6.596314878945151 76.24995000000001 76.24995000000001 64.8529 16.117862681044187 74.01857091511138 15.805929019328243 0.0 49.0449 0.5 55.92005 49.0449;62.7952 39.2363;48.749 64.8529;87.647 2 0 2 24296;26760 CYP1A1_8415;AKR7A3_8015 55.92005 55.92005 9.722930373349357 43.99265 43.99265 6.726494677393277 76.24995000000001 76.24995000000001 16.117862681044187 49.0449;62.7952 39.2363;48.749 64.8529;87.647 0 0 Poly 2,2(1) 3.991214876649596 10.62807559967041 1.8055906295776367 8.822484970092773 4.9616935710477605 5.314037799835205 42.444756 69.39534400000001 34.670204 53.315096 53.911732000000015 98.58816800000001 UP 1.0 0.0 0.0 GO:0044248 4 cellular catabolic process 306 344 12 11 9 7 6 6 32 338 2171 0.75384 0.40868 0.63315 1.74 362246;25044;266684;29277;24296;26760 tp53inp2;sds;cyp2d1;cyp2c11;cyp1a1;akr7a3 TP53INP2_32755;SDS_9798;CYP2D1_32660;CYP2C11_32593;CYP1A1_8415;AKR7A3_8015 306.0460166666667 171.745 49.0449 315.701128758783 261.6128464059228 323.2118651099189 197.61291666666668 112.3581 39.2363 192.01362139019636 168.54456846591748 194.16556410320965 717.7138166666667 309.7615 64.8529 941.8823987546438 637.0866519452555 975.5890896216943 827.265;553.681;126.747;216.743;49.0449;62.7952 495.492;377.484;85.1532;139.563;39.2363;48.749 2498.6;1035.66;250.579;368.944;64.8529;87.647 4 2 4 25044;266684;24296;26760 SDS_9798;CYP2D1_32660;CYP1A1_8415;AKR7A3_8015 198.067025 94.7711 239.4813183804028 137.655625 66.9511 161.10545778916315 359.684725 169.113 458.17644363101994 553.681;126.747;49.0449;62.7952 377.484;85.1532;39.2363;48.749 1035.66;250.579;64.8529;87.647 2 362246;29277 TP53INP2_32755;CYP2C11_32593 522.004 522.004 431.70424626357317 317.52750000000003 317.52750000000003 251.6798095209466 1433.772 1433.772 1505.894199194618 827.265;216.743 495.492;139.563 2498.6;368.944 0 Exp 2,1(0.17);Linear,2(0.34);Poly 2,3(0.5) 2.823965702714308 23.66760742664337 1.5452189445495605 8.822484970092773 3.600949809976313 1.6897605061531067 53.43250228462793 558.6595310487053 43.97002061715338 351.2558127161799 -35.94906638812165 1471.3766997214552 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0046223 6 aflatoxin catabolic process 2 3 1 1 1 1 1 1 37 2 2507 0.99936 0.044111 0.044111 33.33 26760 akr7a3 AKR7A3_8015 62.7952 62.7952 62.7952 62.7952 48.749 48.749 48.749 48.749 87.647 87.647 87.647 87.647 0.0 62.7952 0.0 62.7952 62.7952 48.749 87.647 1 0 1 26760 AKR7A3_8015 62.7952 62.7952 48.749 48.749 87.647 87.647 62.7952 48.749 87.647 0 0 Poly 2,1(1) 1.8055906295776367 1.8055906295776367 1.8055906295776367 1.8055906295776367 0.0 1.8055906295776367 62.7952 62.7952 48.749 48.749 87.647 87.647 UP 1.0 0.0 0.0 GO:1901377 6 organic heteropentacyclic compound catabolic process 2 3 1 1 1 1 1 1 37 2 2507 0.99936 0.044111 0.044111 33.33 26760 akr7a3 AKR7A3_8015 62.7952 62.7952 62.7952 62.7952 48.749 48.749 48.749 48.749 87.647 87.647 87.647 87.647 0.0 62.7952 0.0 62.7952 62.7952 48.749 87.647 1 0 1 26760 AKR7A3_8015 62.7952 62.7952 48.749 48.749 87.647 87.647 62.7952 48.749 87.647 0 0 Poly 2,1(1) 1.8055906295776367 1.8055906295776367 1.8055906295776367 1.8055906295776367 0.0 1.8055906295776367 62.7952 62.7952 48.749 48.749 87.647 87.647 UP 1.0 0.0 0.0 GO:0071230 6 cellular response to amino acid stimulus 36 39 2 2 2 2 2 2 36 37 2472 0.98065 0.11383 0.11383 5.13 24450;24253 hmgcs2;cebpb HMGCS2_8812;CEBPB_32843,CEBPB_8282 24253(-0.009836) 363.58099999999996 363.58099999999996 106.351 363.77815464923117 252.3518692235146 328.0102235196565 234.70935 234.70935 59.8697 247.26060427056504 159.10672863093367 222.94908321968083 744.0894999999999 744.0894999999999 208.329 757.6797652837905 512.4206638635649 683.1820602495934 0.5 363.58099999999996 106.351;620.8109999999999 59.8697;409.549 208.329;1279.85 0 3 0 2 24450;24253 HMGCS2_8812;CEBPB_32843,CEBPB_8282 363.58099999999996 363.58099999999996 363.77815464923117 234.70935 234.70935 247.26060427056504 744.0894999999999 744.0894999999999 757.6797652837905 106.351;620.8109999999999 59.8697;409.549 208.329;1279.85 0 Exp 4,1(0.34);Linear,2(0.67) 1.890321714625962 5.817269563674927 1.5669527053833008 2.578549861907959 0.5562628287502125 1.671766996383667 -140.5897999999999 867.7517999999998 -107.97636399999993 577.3950639999998 -306.0010799999998 1794.1800799999999 DOWN 0.0 1.0 0.0 GO:0031328 7 positive regulation of cellular biosynthetic process 404 436 11 11 8 10 7 7 31 429 2080 0.68043 0.48206 0.82807 1.61 362246;360243;363328;25106;316351;114519;24253 tp53inp2;top2a;ticam1;rgn;npas2;nfil3;cebpb TP53INP2_32755;TOP2A_10059;TICAM1_10015;RGN_9699;NPAS2_9350;NFIL3_9304;CEBPB_32843,CEBPB_8282 24253(-0.009836) 471.5308857142857 620.8109999999999 12.3342 359.8536922815875 405.5031684406733 367.6898459141617 291.02781 409.549 3.46407 218.60222613259313 249.80000031325642 222.79462702761063 1256.4431 1279.85 46.5267 1048.344629123666 1093.707405636389 1081.2166758186288 827.265;12.3342;811.122;752.835;155.028;121.321;620.8109999999999 495.492;3.46407;489.389;458.716;98.033;82.5516;409.549 2498.6;46.5267;2362.87;1994.77;382.695;229.79;1279.85 0 8 0 7 362246;360243;363328;25106;316351;114519;24253 TP53INP2_32755;TOP2A_10059;TICAM1_10015;RGN_9699;NPAS2_9350;NFIL3_9304;CEBPB_32843,CEBPB_8282 471.5308857142857 620.8109999999999 359.8536922815875 291.02781 409.549 218.60222613259313 1256.4431 1279.85 1048.344629123666 827.265;12.3342;811.122;752.835;155.028;121.321;620.8109999999999 495.492;3.46407;489.389;458.716;98.033;82.5516;409.549 2498.6;46.5267;2362.87;1994.77;382.695;229.79;1279.85 0 Exp 2,1(0.13);Hill,1(0.13);Linear,4(0.5);Poly 2,2(0.25) 1.7884313987734122 14.636650443077087 1.5415632724761963 2.846071243286133 0.45789228207509614 1.6228486895561218 204.9475398335615 738.1142315950099 129.0850146102551 452.970605389745 479.8185304535906 2033.067669546409 DOWN 0.0 1.0 0.0 GO:0032270 7 positive regulation of cellular protein metabolic process 403 428 13 12 9 9 6 6 32 422 2087 0.53887 0.63482 1.0 1.4 360772;363328;25106;363140;361921;60628 zfand2a;ticam1;rgn;rassf1;ect2;cxcr4 ZFAND2A_10197;TICAM1_10015;RGN_9699;RASSF1_32475;ECT2_8523;CXCR4_8411 574.1789833333337 781.9784999999999 1.65461E-12 438.062335917939 760.903426443747 335.2255325620908 376.78475000000026 474.0525 1.65461E-12 297.1529051255847 510.4223041176902 236.3261960361422 1148.1057500000002 1231.9 1.65462E-12 969.5663666126079 1316.8580886325476 743.5892521176155 946.037;811.122;752.835;903.848;31.2319;1.65461E-12 687.617;489.389;458.716;608.514;16.4725;1.65461E-12 1292.08;2362.87;1994.77;1171.72;67.1945;1.65462E-12 2 4 2 360772;363140 ZFAND2A_10197;RASSF1_32475 924.9425 924.9425 29.832127991479105 648.0654999999999 648.0654999999999 55.93426771220036 1231.9 1231.9 85.10737218360741 946.037;903.848 687.617;608.514 1292.08;1171.72 4 363328;25106;361921;60628 TICAM1_10015;RGN_9699;ECT2_8523;CXCR4_8411 398.7972250000004 392.03345 443.28243856327316 241.14437500000042 237.59425000000002 269.3144796557157 1106.2086250000004 1030.98225 1247.929886189215 811.122;752.835;31.2319;1.65461E-12 489.389;458.716;16.4725;1.65461E-12 2362.87;1994.77;67.1945;1.65462E-12 0 Exp 2,1(0.17);Exp 4,1(0.17);Hill,1(0.17);Linear,1(0.17);Poly 2,2(0.34) 2.016997127530119 12.36299741268158 1.5415632724761963 2.6542086601257324 0.4676436932678157 1.9491506218910217 223.65611181332753 924.7018548533397 139.012905573175 614.5565944268255 372.29107914472195 1923.9204208552787 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:1901575 4 organic substance catabolic process 296 332 8 7 5 5 4 4 34 328 2181 0.43568 0.74982 0.81039 1.2 362246;25044;24296;26760 tp53inp2;sds;cyp1a1;akr7a3 TP53INP2_32755;SDS_9798;CYP1A1_8415;AKR7A3_8015 373.196525 308.23810000000003 49.0449 383.04746627398004 293.32830728021446 382.7461625525955 240.24032499999998 213.1165 39.2363 231.7044018674566 188.3070245250767 229.58982591004272 921.689975 561.6535 64.8529 1144.4695788567162 745.1105070859718 1151.874952134268 827.265;553.681;49.0449;62.7952 495.492;377.484;39.2363;48.749 2498.6;1035.66;64.8529;87.647 3 1 3 25044;24296;26760 SDS_9798;CYP1A1_8415;AKR7A3_8015 221.84036666666668 62.7952 287.46464501886726 155.15643333333333 48.749 192.60005981375843 396.05330000000004 87.647 554.0328877985223 553.681;49.0449;62.7952 377.484;39.2363;48.749 1035.66;64.8529;87.647 1 362246 TP53INP2_32755 827.265 827.265 495.492 495.492 2498.6 2498.6 827.265 495.492 2498.6 0 Linear,2(0.5);Poly 2,2(0.5) 2.4948614967335225 13.747224926948547 1.5452189445495605 8.822484970092773 3.592344114334147 1.6897605061531067 -2.189991948500392 748.5830419485004 13.17001116989249 467.31063883010745 -199.89021227958187 2043.2701622795819 UP 0.75 0.25 0.0 GO:0098813 4 nuclear chromosome segregation 19 19 7 7 4 4 2 2 36 17 2492 0.99748 0.031598 0.031598 10.53 360243;304951 top2a;nuf2 TOP2A_10059;NUF2_33136 10.94366 10.94366 9.55312 1.966520527022277 11.66947729286501 1.677373392526613 3.87139 3.87139 3.46407 0.576037468225808 3.658782020560519 0.49133986094893567 42.16605 42.16605 37.8054 6.16689037076223 44.442169477420144 5.260142307392142 0.0 9.55312 0.5 10.94366 12.3342;9.55312 3.46407;4.27871 46.5267;37.8054 0 2 0 2 360243;304951 TOP2A_10059;NUF2_33136 10.94366 10.94366 1.966520527022277 3.87139 3.87139 0.576037468225808 42.16605 42.16605 6.16689037076223 12.3342;9.55312 3.46407;4.27871 46.5267;37.8054 0 Exp 5,1(0.5);Hill,1(0.5) 2.331677944073497 4.75632631778717 1.9102550745010376 2.846071243286133 0.6617219588919555 2.378163158893585 8.2182016 13.669118399999999 3.0730427999999996 4.6697372 33.619175999999996 50.712924 DOWN 0.0 1.0 0.0 GO:0032879 4 regulation of localization 652 690 13 12 9 11 7 7 31 683 1826 0.15142 0.92356 0.2722 1.01 362246;25106;24587;499271;361921;60628;24253 tp53inp2;rgn;nefh;itgax;ect2;cxcr4;cebpb TP53INP2_32755;RGN_9699;NEFH_33218;ITGAX_32980;ECT2_8523;CXCR4_8411;CEBPB_32843,CEBPB_8282 24253(-0.009836) 340.06384285714347 148.304 1.65461E-12 376.38628265680154 383.60034694780353 365.8656616311712 210.7733571428578 95.184 1.65461E-12 231.66662637806195 237.44466945591316 222.85719306131202 883.0570714285722 340.985 1.65462E-12 1042.6235072047184 1016.4073547626075 1057.8406349090387 827.265;752.835;2.95157E-12;148.304;31.2319;1.65461E-12;620.8109999999999 495.492;458.716;2.95157E-12;95.184;16.4725;1.65461E-12;409.549 2498.6;1994.77;2.95158E-12;340.985;67.1945;1.65462E-12;1279.85 0 8 0 7 362246;25106;24587;499271;361921;60628;24253 TP53INP2_32755;RGN_9699;NEFH_33218;ITGAX_32980;ECT2_8523;CXCR4_8411;CEBPB_32843,CEBPB_8282 340.06384285714347 148.304 376.38628265680154 210.7733571428578 95.184 231.66662637806195 883.0570714285722 340.985 1042.6235072047184 827.265;752.835;2.95157E-12;148.304;31.2319;1.65461E-12;620.8109999999999 495.492;458.716;2.95157E-12;95.184;16.4725;1.65461E-12;409.549 2498.6;1994.77;2.95158E-12;340.985;67.1945;1.65462E-12;1279.85 0 Exp 2,1(0.13);Exp 4,1(0.13);Hill,2(0.25);Linear,3(0.38);Poly 2,1(0.13) 1.821604810776478 14.737098574638367 1.5669527053833008 2.444005012512207 0.30762943882618743 1.7296647429466248 61.23298263147467 618.8947030828123 39.15231861135078 382.3943956743649 110.6707683111515 1655.4433745459928 DOWN 0.0 1.0 0.0 GO:0048513 4 animal organ development 418 452 21 19 14 15 12 12 26 440 2069 0.98938 0.026645 0.031898 2.65 24522;360243;89829;25106;24587;24450;266674;24296;60628;24253;25612;25748 zfp354a;top2a;socs3;rgn;nefh;hmgcs2;cyp4a8;cyp1a1;cxcr4;cebpb;asns;alas2 ZFP354A_10203;TOP2A_10059;SOCS3_32863;RGN_9699;NEFH_33218;HMGCS2_8812;CYP4A8_32747;CYP1A1_8415;CXCR4_8411;CEBPB_32843,CEBPB_8282;ASNS_8091;ALAS2_8019 24253(-0.009836) 229.12811666666707 87.9406 1.65461E-12 306.83245095521295 214.31730473436832 297.14866091451785 143.76418916666705 58.842650000000006 1.65461E-12 189.1895208472312 133.15231016468854 182.52810989351198 560.1958000000004 148.59 1.65462E-12 831.3954441210498 531.7435054191608 827.7600136930095 99.2226;12.3342;809.124;752.835;2.95157E-12;106.351;76.6586;49.0449;1.65461E-12;620.8109999999999;157.765;65.3911 71.0566;3.46407;488.627;458.716;2.95157E-12;59.8697;57.8156;39.2363;1.65461E-12;409.549;99.5663;37.2697 163.536;46.5267;2346.74;1994.77;2.95158E-12;208.329;112.882;64.8529;1.65462E-12;1279.85;371.219;133.644 4 9 4 89829;266674;24296;25612 SOCS3_32863;CYP4A8_32747;CYP1A1_8415;ASNS_8091 273.148125 117.2118 360.28405136637565 171.31130000000002 78.69095 213.04277976889995 723.9234749999999 242.0505 1090.2109318077103 809.124;76.6586;49.0449;157.765 488.627;57.8156;39.2363;99.5663 2346.74;112.882;64.8529;371.219 8 24522;360243;25106;24587;24450;60628;24253;25748 ZFP354A_10203;TOP2A_10059;RGN_9699;NEFH_33218;HMGCS2_8812;CXCR4_8411;CEBPB_32843,CEBPB_8282;ALAS2_8019 207.11811250000056 82.30685 301.0854939671519 129.9906337500006 48.5697 190.11450867302148 478.3319625000006 148.59 744.204473888832 99.2226;12.3342;752.835;2.95157E-12;106.351;1.65461E-12;620.8109999999999;65.3911 71.0566;3.46407;458.716;2.95157E-12;59.8697;1.65461E-12;409.549;37.2697 163.536;46.5267;1994.77;2.95158E-12;208.329;1.65462E-12;1279.85;133.644 0 Exp 2,1(0.08);Exp 4,1(0.08);Exp 5,1(0.08);Hill,3(0.24);Linear,3(0.24);Poly 2,4(0.31) 2.1160946271071963 31.849019289016724 1.5669527053833008 8.822484970092773 1.9605309964947892 1.7404011487960815 55.52131447466428 402.7349188586698 36.720140793441914 250.8082375398922 89.78954420301011 1030.6020557969907 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0010035 4 response to inorganic substance 271 293 12 12 10 9 7 7 31 286 2223 0.93733 0.13866 0.19452 2.39 24314;24587;24567;24450;361921;24296;25748 nqo1;nefh;mt1;hmgcs2;ect2;cyp1a1;alas2 NQO1_33055;NEFH_33218;MT1A_9255;HMGCS2_8812;ECT2_8523;CYP1A1_8415;ALAS2_8019 65.87971428571471 49.0449 2.95157E-12 55.75648411988835 75.66356601020169 51.08457907321952 39.71220000000043 37.2697 2.95157E-12 33.9953321464378 46.30010288204232 30.48711820136316 251.76080000000044 79.3552 2.95158E-12 427.03542745230135 268.0894278940508 420.5601705627445 40.5511;2.95157E-12;168.588;106.351;31.2319;49.0449;65.3911 21.5832;2.95157E-12;103.554;59.8697;16.4725;39.2363;37.2697 79.3552;2.95158E-12;1208.95;208.329;67.1945;64.8529;133.644 2 5 2 24314;24296 NQO1_33055;CYP1A1_8415 44.798 44.798 6.006023578042245 30.409750000000003 30.409750000000003 12.482626718964237 72.10405 72.10405 10.254674672801642 40.5511;49.0449 21.5832;39.2363 79.3552;64.8529 5 24587;24567;24450;361921;25748 NEFH_33218;MT1A_9255;HMGCS2_8812;ECT2_8523;ALAS2_8019 74.3124000000006 65.3911 65.90184464986461 43.43318000000059 37.2697 40.42270421393077 323.6235000000006 133.644 500.9181683533744 2.95157E-12;168.588;106.351;31.2319;65.3911 2.95157E-12;103.554;59.8697;16.4725;37.2697 2.95158E-12;1208.95;208.329;67.1945;133.644 0 Exp 4,3(0.43);Exp 5,1(0.15);Hill,1(0.15);Poly 2,2(0.29) 2.717585174799741 22.36014187335968 1.7132161855697632 8.822484970092773 2.501344206942097 2.444005012512207 24.57473281676163 107.18469575466776 14.528105512976492 64.89629448702435 -64.59147177482677 568.1130717748275 DOWN 0.2857142857142857 0.7142857142857143 0.0 GO:0070542 5 response to fatty acid 60 63 3 3 3 2 2 2 36 61 2448 0.93411 0.24161 0.24161 3.17 24450;25748 hmgcs2;alas2 HMGCS2_8812;ALAS2_8019 85.87105 85.87105 65.3911 28.963023046722903 88.71740725534308 28.68193167753723 48.5697 48.5697 37.2697 15.980613254815978 50.14020368703912 15.825518517192213 170.9865 170.9865 133.644 52.810269952917295 176.17645875515558 52.297736745862906 106.351;65.3911 59.8697;37.2697 208.329;133.644 0 2 0 2 24450;25748 HMGCS2_8812;ALAS2_8019 85.87105 85.87105 28.963023046722903 48.5697 48.5697 15.980613254815978 170.9865 170.9865 52.810269952917295 106.351;65.3911 59.8697;37.2697 208.329;133.644 0 Exp 4,1(0.5);Exp 5,1(0.5) 2.1018119227750596 4.291766047477722 1.7132161855697632 2.578549861907959 0.6118833105278234 2.145883023738861 45.73034799999999 126.011752 26.421699999999998 70.7177 97.79520000000002 244.1778 DOWN 0.0 1.0 0.0 GO:0017015 7 regulation of transforming growth factor beta receptor signaling pathway 30 31 1 1 1 1 1 1 37 30 2479 0.92313 0.37423 0.37423 3.23 338475 nrep NREP_9364 114.178 114.178 114.178 114.178 79.0815 79.0815 79.0815 79.0815 204.229 204.229 204.229 204.22899999999998 114.178 79.0815 204.229 0 1 0 1 338475 NREP_9364 114.178 114.178 79.0815 79.0815 204.229 204.229 114.178 79.0815 204.229 0 Poly 2,1(1) 1.6721540689468384 1.6721540689468384 1.6721540689468384 1.6721540689468384 0.0 1.6721540689468384 114.178 114.178 79.0815 79.0815 204.229 204.229 DOWN 0.0 1.0 0.0 GO:0002376 2 immune system process 352 390 9 8 8 6 6 6 32 384 2125 0.63875 0.53697 0.82365 1.54 363328;114519;499271;170568;60628;24253 ticam1;nfil3;itgax;dmbt1;cxcr4;cebpb TICAM1_10015;NFIL3_9304;ITGAX_32980;DMBT1_32993;CXCR4_8411;CEBPB_32843,CEBPB_8282 24253(-0.009836) 284.0341216666669 134.8125 1.65461E-12 345.2514358017829 243.2963870421109 312.8950129299338 179.62836166666693 88.86779999999999 1.65461E-12 214.24745030735815 153.99717032804017 193.3452627326841 703.7057133333336 285.3875 1.65462E-12 940.1181694736106 600.9184118463004 861.9757994630477 811.122;121.321;148.304;2.64673;1.65461E-12;620.8109999999999 489.389;82.5516;95.184;1.09657;1.65461E-12;409.549 2362.87;229.79;340.985;8.73928;1.65462E-12;1279.85 1 6 1 170568 DMBT1_32993 2.64673 2.64673 1.09657 1.09657 8.73928 8.73928 2.64673 1.09657 8.73928 5 363328;114519;499271;60628;24253 TICAM1_10015;NFIL3_9304;ITGAX_32980;CXCR4_8411;CEBPB_32843,CEBPB_8282 340.3116000000003 148.304 353.8990437219345 215.3347200000003 95.184 218.66728667839607 842.6990000000003 340.985 979.7368078621927 811.122;121.321;148.304;1.65461E-12;620.8109999999999 489.389;82.5516;95.184;1.65461E-12;409.549 2362.87;229.79;340.985;1.65462E-12;1279.85 0 Exp 4,1(0.15);Hill,1(0.15);Linear,3(0.43);Poly 2,2(0.29) 1.7323479420243035 12.199524164199829 1.5415632724761963 2.1583378314971924 0.21346783427473318 1.671766996383667 7.775437111973702 560.29280622136 8.194697231194937 351.06202610213893 -48.545492289037156 1455.9569189557046 DOWN 0.16666666666666666 0.8333333333333334 0.0 GO:1904880 5 response to hydrogen sulfide 3 3 1 1 1 1 1 1 37 2 2507 0.99936 0.044111 0.044111 33.33 24314 nqo1 NQO1_33055 40.5511 40.5511 40.5511 40.5511 21.5832 21.5832 21.5832 21.5832 79.3552 79.3552 79.3552 79.3552 0.0 40.5511 0.0 40.5511 40.5511 21.5832 79.3552 1 0 1 24314 NQO1_33055 40.5511 40.5511 21.5832 21.5832 79.3552 79.3552 40.5511 21.5832 79.3552 0 0 Exp 4,1(1) 2.5798087120056152 2.5798087120056152 2.5798087120056152 2.5798087120056152 0.0 2.5798087120056152 40.5511 40.5511 21.5832 21.5832 79.3552 79.3552 UP 1.0 0.0 0.0 GO:0043086 5 negative regulation of catalytic activity 212 228 10 9 7 7 4 4 34 224 2285 0.75037 0.44661 0.77138 1.75 299276;25106;24314;83928 serpina3m;rgn;nqo1;fetub SERPINA3M_9809;RGN_9699;NQO1_33055;FETUB_33027 451.53677500000003 506.3805 40.5511 299.348878750535 390.2449277224128 281.87936490371385 289.6473 339.145 21.5832 190.65142744555223 253.4687422715352 185.27423963623534 992.3715500000001 947.6805 79.3552 784.0218631395489 799.3132372886827 660.2857049688347 466.86;752.835;40.5511;545.901 296.126;458.716;21.5832;382.164 918.743;1994.77;79.3552;976.618 2 2 2 24314;83928 NQO1_33055;FETUB_33027 293.22605 293.22605 357.33634116194366 201.87359999999998 201.87359999999998 254.9691288456703 527.9866000000001 527.9866000000001 634.460610386429 40.5511;545.901 21.5832;382.164 79.3552;976.618 2 299276;25106 SERPINA3M_9809;RGN_9699 609.8475000000001 609.8475000000001 202.21486174982272 377.421 377.421 114.96849155312071 1456.7565 1456.7565 760.8659884398173 466.86;752.835 296.126;458.716 918.743;1994.77 0 Exp 2,3(0.75);Exp 4,1(0.25) 1.806473967941653 7.399102687835693 1.5054508447647095 2.5798087120056152 0.49416748969658514 1.6569215655326843 158.17487382447575 744.8986761755243 102.80890110335878 476.48569889664117 224.03012412324188 1760.7129758767583 CONFLICT 0.5 0.5 0.0 GO:0043524 8 negative regulation of neuron apoptotic process 75 76 2 2 2 2 2 2 36 74 2435 0.89765 0.31436 0.31436 2.63 24567;24253 mt1;cebpb MT1A_9255;CEBPB_32843,CEBPB_8282 24253(-0.009836) 394.69949999999994 394.69949999999994 168.588 319.7699499085241 333.9360410085054 308.00718330467225 256.5515 256.5515 103.554 216.37113950917762 215.4361329485622 208.4119075219817 1244.4 1244.4 1208.95 50.13387078611953 1234.8734406642363 48.2896918031703 168.588;620.8109999999999 103.554;409.549 1208.95;1279.85 0 3 0 2 24567;24253 MT1A_9255;CEBPB_32843,CEBPB_8282 394.69949999999994 394.69949999999994 319.7699499085241 256.5515 256.5515 216.37113950917762 1244.4 1244.4 50.13387078611953 168.588;620.8109999999999 103.554;409.549 1208.95;1279.85 0 Linear,2(0.67);Poly 2,1(0.34) 1.7563536569879246 5.306975603103638 1.5669527053833008 2.06825590133667 0.26441582832784516 1.671766996383667 -48.47903999999994 837.8780399999998 -43.32359999999994 556.4266 1174.9180000000001 1313.882 DOWN 0.0 1.0 0.0 GO:0010628 7 positive regulation of gene expression 455 488 14 14 10 10 7 7 31 481 2028 0.55273 0.61223 1.0 1.43 362246;360243;363328;316351;114519;499271;24253 tp53inp2;top2a;ticam1;npas2;nfil3;itgax;cebpb TP53INP2_32755;TOP2A_10059;TICAM1_10015;NPAS2_9350;NFIL3_9304;ITGAX_32980;CEBPB_32843,CEBPB_8282 24253(-0.009836) 385.1693142857143 155.028 12.3342 353.57777241821174 330.3372572929157 341.21378717393793 239.09466714285713 98.033 3.46407 215.28187304920704 204.60615567317376 206.74262506882843 1020.1881 382.695 46.5267 1040.5431846629929 881.3034163652932 1013.6664083219309 827.265;12.3342;811.122;155.028;121.321;148.304;620.8109999999999 495.492;3.46407;489.389;98.033;82.5516;95.184;409.549 2498.6;46.5267;2362.87;382.695;229.79;340.985;1279.85 0 8 0 7 362246;360243;363328;316351;114519;499271;24253 TP53INP2_32755;TOP2A_10059;TICAM1_10015;NPAS2_9350;NFIL3_9304;ITGAX_32980;CEBPB_32843,CEBPB_8282 385.1693142857143 155.028 353.57777241821174 239.09466714285713 98.033 215.28187304920704 1020.1881 382.695 1040.5431846629929 827.265;12.3342;811.122;155.028;121.321;148.304;620.8109999999999 495.492;3.46407;489.389;98.033;82.5516;95.184;409.549 2498.6;46.5267;2362.87;382.695;229.79;340.985;1279.85 0 Hill,1(0.13);Linear,4(0.5);Poly 2,3(0.38) 1.8075719246176967 14.789093732833862 1.5415632724761963 2.846071243286133 0.45560184445216356 1.6228486895561218 123.23523490285555 647.1033936685731 79.61162373971067 398.5777105460036 249.34292138839737 1791.0332786116023 DOWN 0.0 1.0 0.0 GO:0007166 5 cell surface receptor signaling pathway 368 386 6 5 5 4 4 4 34 382 2127 0.29579 0.8501 0.64664 1.04 363328;89829;499271;60628 ticam1;socs3;itgax;cxcr4 TICAM1_10015;SOCS3_32863;ITGAX_32980;CXCR4_8411 442.1375000000004 478.714 1.65461E-12 429.2056022665589 462.2042808335243 404.26029309719866 268.3000000000004 291.9055 1.65461E-12 257.79731851850795 281.2202067323107 241.7742667174913 1262.6487500000003 1343.8625 1.65462E-12 1268.7903124917511 1307.9798108541333 1211.310755044928 811.122;809.124;148.304;1.65461E-12 489.389;488.627;95.184;1.65461E-12 2362.87;2346.74;340.985;1.65462E-12 1 3 1 89829 SOCS3_32863 809.124 809.124 488.627 488.627 2346.74 2346.74 809.124 488.627 2346.74 3 363328;499271;60628 TICAM1_10015;ITGAX_32980;CXCR4_8411 319.8086666666672 148.304 431.9028973476941 194.85766666666723 95.184 259.47355973264985 901.2850000000004 340.985 1277.200347136266 811.122;148.304;1.65461E-12 489.389;95.184;1.65461E-12 2362.87;340.985;1.65462E-12 0 Hill,1(0.25);Linear,2(0.5);Poly 2,1(0.25) 1.7193816284428831 6.893737196922302 1.5415632724761963 1.8672927618026733 0.13478764002955299 1.7424405813217163 21.516009778772684 862.758990221228 15.658627851862633 520.9413721481382 19.23424375808463 2506.0632562419164 DOWN 0.25 0.75 0.0 GO:0051239 4 regulation of multicellular organismal process 724 769 17 16 11 13 9 9 29 760 1749 0.24516 0.85595 0.47721 1.17 363328;25106;338475;316351;499271;361921;170568;60628;24253 ticam1;rgn;nrep;npas2;itgax;ect2;dmbt1;cxcr4;cebpb TICAM1_10015;RGN_9699;NREP_9364;NPAS2_9350;ITGAX_32980;ECT2_8523;DMBT1_32993;CXCR4_8411;CEBPB_32843,CEBPB_8282 24253(-0.009836) 292.90629222222236 148.304 1.65461E-12 335.03463986224125 254.18758743506731 301.2280627268368 183.0579522222224 95.184 1.65461E-12 206.53610847776827 159.8449182498787 185.1040287177765 737.9258644444446 340.985 1.65462E-12 908.8793905884488 634.4382261368737 826.894064191208 811.122;752.835;114.178;155.028;148.304;31.2319;2.64673;1.65461E-12;620.8109999999999 489.389;458.716;79.0815;98.033;95.184;16.4725;1.09657;1.65461E-12;409.549 2362.87;1994.77;204.229;382.695;340.985;67.1945;8.73928;1.65462E-12;1279.85 1 9 1 170568 DMBT1_32993 2.64673 2.64673 1.09657 1.09657 8.73928 8.73928 2.64673 1.09657 8.73928 8 363328;25106;338475;316351;499271;361921;60628;24253 TICAM1_10015;RGN_9699;NREP_9364;NPAS2_9350;ITGAX_32980;ECT2_8523;CXCR4_8411;CEBPB_32843,CEBPB_8282 329.1887375000002 151.666 338.73793897703314 205.8031250000002 96.60849999999999 208.39818519341912 829.0741875000002 361.84000000000003 926.6157135196696 811.122;752.835;114.178;155.028;148.304;31.2319;1.65461E-12;620.8109999999999 489.389;458.716;79.0815;98.033;95.184;16.4725;1.65461E-12;409.549 2362.87;1994.77;204.229;382.695;340.985;67.1945;1.65462E-12;1279.85 0 Exp 2,1(0.1);Exp 4,2(0.2);Hill,1(0.1);Linear,3(0.3);Poly 2,3(0.3) 1.7064937340692512 17.14518964290619 1.5415632724761963 2.1538212299346924 0.18248763715349675 1.6719605326652527 74.01699417889151 511.7955902655533 48.12102801674712 317.99487642769765 144.12466259332473 1331.7270662955643 DOWN 0.1111111111111111 0.8888888888888888 0.0 GO:0120162 5 positive regulation of cold-induced thermogenesis 37 42 2 2 2 2 2 2 36 40 2469 0.97643 0.12869 0.12869 4.76 60628;24253 cxcr4;cebpb CXCR4_8411;CEBPB_32843,CEBPB_8282 24253(-0.009836) 310.4055000000008 310.4055000000008 1.65461E-12 438.9796679352005 370.53694561983536 430.66410037967734 204.7745000000008 204.7745000000008 1.65461E-12 289.59487512816816 244.44321305785192 284.10909543548064 639.9250000000008 639.9250000000008 1.65462E-12 904.9906139016016 763.8906363636371 887.8474267867848 1.65461E-12;620.8109999999999 1.65461E-12;409.549 1.65462E-12;1279.85 0 3 0 2 60628;24253 CXCR4_8411;CEBPB_32843,CEBPB_8282 310.4055000000008 310.4055000000008 438.9796679352005 204.7745000000008 204.7745000000008 289.59487512816816 639.9250000000008 639.9250000000008 904.9906139016016 1.65461E-12;620.8109999999999 1.65461E-12;409.549 1.65462E-12;1279.85 0 Hill,1(0.34);Linear,2(0.67) 1.6594565207781928 4.983199715614319 1.5669527053833008 1.744480013847351 0.08924606784715461 1.671766996383667 -297.9892799999975 918.800279999999 -196.5835199999975 606.1325199999991 -614.3279999999975 1894.1779999999992 DOWN 0.0 1.0 0.0 GO:0007420 5 brain development 75 79 5 4 4 4 4 4 34 75 2434 0.99431 0.028442 0.028442 5.06 360243;24587;24450;60628 top2a;nefh;hmgcs2;cxcr4 TOP2A_10059;NEFH_33218;HMGCS2_8812;CXCR4_8411 29.67130000000115 6.167100000001476 1.65461E-12 51.44940400004561 51.08037697680155 57.40013516493558 15.833442500001151 1.7320350000014757 1.65461E-12 29.402886215764198 27.69876255726554 33.30178664462552 63.713925000001154 23.263350000001473 1.65462E-12 98.87340238619437 106.85251270329726 106.81335829348151 2.5 59.3426 12.3342;2.95157E-12;106.351;1.65461E-12 3.46407;2.95157E-12;59.8697;1.65461E-12 46.5267;2.95158E-12;208.329;1.65462E-12 0 4 0 4 360243;24587;24450;60628 TOP2A_10059;NEFH_33218;HMGCS2_8812;CXCR4_8411 29.67130000000115 6.167100000001476 51.44940400004561 15.833442500001151 1.7320350000014757 29.402886215764198 63.713925000001154 23.263350000001473 98.87340238619437 12.3342;2.95157E-12;106.351;1.65461E-12 3.46407;2.95157E-12;59.8697;1.65461E-12 46.5267;2.95158E-12;208.329;1.65462E-12 0 Exp 4,1(0.25);Hill,3(0.75) 2.365088235899265 9.61310613155365 1.744480013847351 2.846071243286133 0.4699147291352906 2.511277437210083 -20.749115920043536 80.09171592004584 -12.981385991447766 44.64827099145007 -33.18200933846933 160.60985933847164 DOWN 0.0 1.0 0.0 GO:0019725 4 cellular homeostasis 217 230 6 5 5 6 5 5 33 225 2284 0.87787 0.25542 0.38433 2.17 25106;24314;24567;60628;25748 rgn;nqo1;mt1;cxcr4;alas2 RGN_9699;NQO1_33055;MT1A_9255;CXCR4_8411;ALAS2_8019 205.4730400000003 65.3911 1.65461E-12 312.25269726825877 149.9787850306132 240.14390341896333 124.22458000000033 37.2697 1.65461E-12 190.94497456822972 89.9937405448347 147.17148465494853 683.3438400000002 133.644 1.65462E-12 884.5947382238534 563.7328617840814 762.9313695241891 752.835;40.5511;168.588;1.65461E-12;65.3911 458.716;21.5832;103.554;1.65461E-12;37.2697 1994.77;79.3552;1208.95;1.65462E-12;133.644 1 4 1 24314 NQO1_33055 40.5511 40.5511 21.5832 21.5832 79.3552 79.3552 40.5511 21.5832 79.3552 4 25106;24567;60628;25748 RGN_9699;MT1A_9255;CXCR4_8411;ALAS2_8019 246.7035250000004 116.98955 344.4841215201395 149.8849250000004 70.41185 210.29413301458428 834.3410000000003 671.297 944.10955526217 752.835;168.588;1.65461E-12;65.3911 458.716;103.554;1.65461E-12;37.2697 1994.77;1208.95;1.65462E-12;133.644 0 Exp 2,1(0.2);Exp 4,1(0.2);Exp 5,1(0.2);Hill,1(0.2);Poly 2,1(0.2) 1.938113424051966 9.820610284805298 1.7132161855697632 2.5798087120056152 0.3752489572725265 1.744480013847351 -68.22851684179952 479.17459684180017 -43.146069693839536 291.59522969384017 -92.03763514520915 1458.72531514521 DOWN 0.2 0.8 0.0 GO:0040008 4 regulation of growth 171 186 5 5 5 3 3 3 35 183 2326 0.70005 0.53296 0.75454 1.61 89829;24567;60628 socs3;mt1;cxcr4 SOCS3_32863;MT1A_9255;CXCR4_8411 325.90400000000056 168.588 1.65461E-12 426.8859973529227 415.1256140581811 422.5498682221054 197.3936666666672 103.554 1.65461E-12 257.47523873633565 251.41207318678448 254.54823327347486 1185.2300000000005 1208.95 1.65462E-12 1173.5498011162535 1500.8828715282348 1026.4169026776706 809.124;168.588;1.65461E-12 488.627;103.554;1.65461E-12 2346.74;1208.95;1.65462E-12 1 2 1 89829 SOCS3_32863 809.124 809.124 488.627 488.627 2346.74 2346.74 809.124 488.627 2346.74 2 24567;60628 MT1A_9255;CXCR4_8411 84.29400000000082 84.29400000000082 119.2097180266765 51.777000000000825 51.777000000000825 73.22373561899059 604.4750000000008 604.4750000000008 854.8567431154755 168.588;1.65461E-12 103.554;1.65461E-12 1208.95;1.65462E-12 0 Hill,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 1.8449016129307478 5.5531370639801025 1.7404011487960815 2.06825590133667 0.1881206178772248 1.744480013847351 -157.16298115058328 808.9709811505844 -93.96699418574235 488.7543275190768 -142.76661542052466 2513.2266154205254 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:2001141 7 regulation of RNA biosynthetic process 476 510 17 17 11 13 8 8 30 502 2007 0.65463 0.50162 0.8391 1.57 24522;362246;360243;363328;25106;316351;114519;24253 zfp354a;tp53inp2;top2a;ticam1;rgn;npas2;nfil3;cebpb ZFP354A_10203;TP53INP2_32755;TOP2A_10059;TICAM1_10015;RGN_9699;NPAS2_9350;NFIL3_9304;CEBPB_32843,CEBPB_8282 24253(-0.009836) 424.99235 387.91949999999997 12.3342 358.2207731577633 383.6774234658812 360.6862330589667 263.53140875 253.791 3.46407 216.81477156978556 237.062633750872 218.11918112782638 1119.8297125 831.2724999999999 46.5267 1044.6666560987105 1027.422809177583 1062.5482713780266 99.2226;827.265;12.3342;811.122;752.835;155.028;121.321;620.8109999999999 71.0566;495.492;3.46407;489.389;458.716;98.033;82.5516;409.549 163.536;2498.6;46.5267;2362.87;1994.77;382.695;229.79;1279.85 0 9 0 8 24522;362246;360243;363328;25106;316351;114519;24253 ZFP354A_10203;TP53INP2_32755;TOP2A_10059;TICAM1_10015;RGN_9699;NPAS2_9350;NFIL3_9304;CEBPB_32843,CEBPB_8282 424.99235 387.91949999999997 358.2207731577633 263.53140875 253.791 216.81477156978556 1119.8297125 831.2724999999999 1044.6666560987105 99.2226;827.265;12.3342;811.122;752.835;155.028;121.321;620.8109999999999 71.0566;495.492;3.46407;489.389;458.716;98.033;82.5516;409.549 163.536;2498.6;46.5267;2362.87;1994.77;382.695;229.79;1279.85 0 Exp 2,1(0.12);Hill,1(0.12);Linear,4(0.45);Poly 2,3(0.34) 1.7933914692843165 16.470220923423767 1.5415632724761963 2.846071243286133 0.42832107396728564 1.671766996383667 176.75801889549248 673.2266811045076 113.28643741636057 413.7763800836396 395.91265342526447 1843.7467715747352 DOWN 0.0 1.0 0.0 GO:0031398 10 positive regulation of protein ubiquitination 34 35 4 4 2 4 2 2 36 33 2476 0.98557 0.094812 0.094812 5.71 363328;363140 ticam1;rassf1 TICAM1_10015;RASSF1_32475 857.4849999999999 857.4849999999999 811.122 65.56718339230436 875.0581514448429 60.67474132283618 548.9515 548.9515 489.389 84.23409530884747 571.5277101877242 77.94877984689226 1767.295 1767.295 1171.72 842.2702424103554 1541.551849820713 779.4223640262471 0.5 857.4849999999999 811.122;903.848 489.389;608.514 2362.87;1171.72 1 1 1 363140 RASSF1_32475 903.848 903.848 608.514 608.514 1171.72 1171.72 903.848 608.514 1171.72 1 363328 TICAM1_10015 811.122 811.122 489.389 489.389 2362.87 2362.87 811.122 489.389 2362.87 0 Linear,1(0.5);Poly 2,1(0.5) 2.0227779383654756 4.195771932601929 1.5415632724761963 2.6542086601257324 0.7867590986629219 2.0978859663009644 766.6135199999999 948.3564799999999 432.209 665.694 599.9680000000003 2934.622 CONFLICT 0.5 0.5 0.0 GO:0071353 7 cellular response to interleukin-4 15 15 1 1 1 1 1 1 37 14 2495 0.97986 0.20237 0.20237 6.67 114519 nfil3 NFIL3_9304 121.321 121.321 121.321 121.321 82.5516 82.5516 82.5516 82.5516 229.79 229.79 229.79 229.79 0.0 121.321 121.321 82.5516 229.79 0 1 0 1 114519 NFIL3_9304 121.321 121.321 82.5516 82.5516 229.79 229.79 121.321 82.5516 229.79 0 Poly 2,1(1) 2.1583378314971924 2.1583378314971924 2.1583378314971924 2.1583378314971924 0.0 2.1583378314971924 121.321 121.321 82.5516 82.5516 229.79 229.79 DOWN 0.0 1.0 0.0 GO:0019932 6 second-messenger-mediated signaling 68 74 3 3 3 3 3 3 35 71 2438 0.97703 0.096292 0.096292 4.05 24567;60628;54223 mt1;cxcr4;adcy4 MT1A_9255;CXCR4_8411;ADCY4_7988 295.00666666666723 168.588 1.65461E-12 374.5730397630519 351.10400536041783 362.1932225649047 165.75400000000056 103.554 1.65461E-12 204.09097803675633 197.7657922132885 195.47487319166672 1098.6766666666672 1208.95 1.65462E-12 1047.9007050447726 1340.016057977148 893.2826208265641 168.588;1.65461E-12;716.432 103.554;1.65461E-12;393.708 1208.95;1.65462E-12;2087.08 0 3 0 3 24567;60628;54223 MT1A_9255;CXCR4_8411;ADCY4_7988 295.00666666666723 168.588 374.5730397630519 165.75400000000056 103.554 204.09097803675633 1098.6766666666672 1208.95 1047.9007050447726 168.588;1.65461E-12;716.432 103.554;1.65461E-12;393.708 1208.95;1.65462E-12;2087.08 0 Exp 2,1(0.34);Hill,1(0.34);Poly 2,1(0.34) 1.8127799760586658 5.463804125785828 1.6510682106018066 2.06825590133667 0.21893764698568413 1.744480013847351 -128.86263019654666 718.8759635298811 -65.1966829730421 396.7046829730432 -87.13461145086512 2284.4879447841995 DOWN 0.0 1.0 0.0 GO:0009314 4 response to radiation 159 166 8 8 7 4 4 4 34 162 2347 0.90269 0.23256 0.3083 2.41 360243;89829;361921;25612 top2a;socs3;ect2;asns TOP2A_10059;SOCS3_32863;ECT2_8523;ASNS_8091 252.613775 94.49844999999999 12.3342 376.58293880155514 325.5031298723404 410.6309131571826 152.0324675 58.0194 3.46407 228.39851981813916 196.1670757904255 248.9158041173011 707.92005 219.20675 46.5267 1102.5831517299318 924.1339860957446 1201.6644206938279 12.3342;809.124;31.2319;157.765 3.46407;488.627;16.4725;99.5663 46.5267;2346.74;67.1945;371.219 2 2 2 89829;25612 SOCS3_32863;ASNS_8091 483.4445 483.4445 460.5803658868885 294.09665 294.09665 275.10745926318504 1358.9795 1358.9795 1396.9042954764295 809.124;157.765 488.627;99.5663 2346.74;371.219 2 360243;361921 TOP2A_10059;ECT2_8523 21.78305 21.78305 13.362691818829017 9.968285 9.968285 9.198349065590524 56.860600000000005 56.860600000000005 14.614341532207316 12.3342;31.2319 3.46407;16.4725 46.5267;67.1945 0 Exp 4,1(0.25);Hill,1(0.25);Linear,1(0.25);Poly 2,1(0.25) 2.0325462734206936 8.34006154537201 1.5997679233551025 2.846071243286133 0.5592150255957141 1.947111189365387 -116.43750502552405 621.665055025524 -71.79808192177637 375.86301692177636 -372.61143869533316 1788.451538695333 CONFLICT 0.5 0.5 0.0 GO:0051716 3 cellular response to stimulus 785 838 34 31 23 23 17 17 21 821 1688 0.95632 0.084295 0.12072 2.03 360772;360243;363328;89829;363140;338475;24314;114519;24587;24567;291885;24450;361921;24296;60628;24253;25612 zfand2a;top2a;ticam1;socs3;rassf1;nrep;nqo1;nfil3;nefh;mt1;mcm5;hmgcs2;ect2;cyp1a1;cxcr4;cebpb;asns ZFAND2A_10197;TOP2A_10059;TICAM1_10015;SOCS3_32863;RASSF1_32475;NREP_9364;NQO1_33055;NFIL3_9304;NEFH_33218;MT1A_9255;MCM5_9209;HMGCS2_8812;ECT2_8523;CYP1A1_8415;CXCR4_8411;CEBPB_32843,CEBPB_8282;ASNS_8091 24253(-0.009836) 288.51810000000023 114.178 1.65461E-12 361.6385908156838 328.2201413666109 375.9613120140457 188.16177647058853 79.0815 1.65461E-12 240.68709067942143 215.74307758731194 252.60920238273968 645.2818764705885 208.329 1.65462E-12 808.0807729929866 689.2140277972557 788.1188649961277 946.037;12.3342;811.122;809.124;903.848;114.178;40.5511;121.321;2.95157E-12;168.588;12.5006;106.351;31.2319;49.0449;1.65461E-12;620.8109999999999;157.765 687.617;3.46407;489.389;488.627;608.514;79.0815;21.5832;82.5516;2.95157E-12;103.554;9.67503;59.8697;16.4725;39.2363;1.65461E-12;409.549;99.5663 1292.08;46.5267;2362.87;2346.74;1171.72;204.229;79.3552;229.79;2.95158E-12;1208.95;36.0856;208.329;67.1945;64.8529;1.65462E-12;1279.85;371.219 6 12 6 360772;89829;363140;24314;24296;25612 ZFAND2A_10197;SOCS3_32863;RASSF1_32475;NQO1_33055;CYP1A1_8415;ASNS_8091 484.395 483.4445 444.4586263874783 324.1906333333333 294.09665 304.3629877048828 887.6611833333333 771.4695 891.0936590938181 946.037;809.124;903.848;40.5511;49.0449;157.765 687.617;488.627;608.514;21.5832;39.2363;99.5663 1292.08;2346.74;1171.72;79.3552;64.8529;371.219 11 360243;363328;338475;114519;24587;24567;291885;24450;361921;60628;24253 TOP2A_10059;TICAM1_10015;NREP_9364;NFIL3_9304;NEFH_33218;MT1A_9255;MCM5_9209;HMGCS2_8812;ECT2_8523;CXCR4_8411;CEBPB_32843,CEBPB_8282 181.67615454545495 106.351 273.6838319864631 113.96421818181861 59.8697 170.91492470813986 513.0749818181822 204.229 770.2545917557059 12.3342;811.122;114.178;121.321;2.95157E-12;168.588;12.5006;106.351;31.2319;1.65461E-12;620.8109999999999 3.46407;489.389;79.0815;82.5516;2.95157E-12;103.554;9.67503;59.8697;16.4725;1.65461E-12;409.549 46.5267;2362.87;204.229;229.79;2.95158E-12;1208.95;36.0856;208.329;67.1945;1.65462E-12;1279.85 0 Exp 4,3(0.17);Exp 5,1(0.06);Hill,3(0.17);Linear,4(0.23);Poly 2,7(0.39) 2.2075593945018746 44.17325532436371 1.5415632724761963 8.822484970092773 1.6478691784688404 2.111038565635681 116.60602634494884 460.4301736550517 73.74639627741283 302.5771566637642 261.14466076950214 1029.419092171675 DOWN 0.35294117647058826 0.6470588235294118 0.0 GO:0032502 2 developmental process 992 1073 36 32 26 22 17 17 21 1056 1453 0.69122 0.43227 0.7436 1.58 24522;362246;360243;89829;25106;338475;24314;24587;24450;361921;170568;266674;24296;60628;24253;25612;25748 zfp354a;tp53inp2;top2a;socs3;rgn;nrep;nqo1;nefh;hmgcs2;ect2;dmbt1;cyp4a8;cyp1a1;cxcr4;cebpb;asns;alas2 ZFP354A_10203;TP53INP2_32755;TOP2A_10059;SOCS3_32863;RGN_9699;NREP_9364;NQO1_33055;NEFH_33218;HMGCS2_8812;ECT2_8523;DMBT1_32993;CYP4A8_32747;CYP1A1_8415;CXCR4_8411;CEBPB_32843,CEBPB_8282;ASNS_8091;ALAS2_8019 24253(-0.009836) 221.49471352941202 76.6586 1.65461E-12 309.3962260425533 212.81857720169927 303.96331904723706 137.58212000000026 57.8156 1.65461E-12 189.15130156358026 131.24816431615503 184.94447258872057 563.5569164705885 133.644 1.65462E-12 875.5603791976337 549.508293055692 881.3167846242471 99.2226;827.265;12.3342;809.124;752.835;114.178;40.5511;2.95157E-12;106.351;31.2319;2.64673;76.6586;49.0449;1.65461E-12;620.8109999999999;157.765;65.3911 71.0566;495.492;3.46407;488.627;458.716;79.0815;21.5832;2.95157E-12;59.8697;16.4725;1.09657;57.8156;39.2363;1.65461E-12;409.549;99.5663;37.2697 163.536;2498.6;46.5267;2346.74;1994.77;204.229;79.3552;2.95158E-12;208.329;67.1945;8.73928;112.882;64.8529;1.65462E-12;1279.85;371.219;133.644 6 12 6 89829;24314;170568;266674;24296;25612 SOCS3_32863;NQO1_33055;DMBT1_32993;CYP4A8_32747;CYP1A1_8415;ASNS_8091 189.29838833333335 62.85175 308.05892413896663 117.98749500000001 48.52595 184.6578821472264 497.29806333333335 96.1186 914.8204040285573 809.124;40.5511;2.64673;76.6586;49.0449;157.765 488.627;21.5832;1.09657;57.8156;39.2363;99.5663 2346.74;79.3552;8.73928;112.882;64.8529;371.219 11 24522;362246;360243;25106;338475;24587;24450;361921;60628;24253;25748 ZFP354A_10203;TP53INP2_32755;TOP2A_10059;RGN_9699;NREP_9364;NEFH_33218;HMGCS2_8812;ECT2_8523;CXCR4_8411;CEBPB_32843,CEBPB_8282;ALAS2_8019 239.05634545454586 99.2226 323.6514716651703 148.2700972727277 59.8697 199.5992268327459 599.6981090909095 163.536 896.6885928926388 99.2226;827.265;12.3342;752.835;114.178;2.95157E-12;106.351;31.2319;1.65461E-12;620.8109999999999;65.3911 71.0566;495.492;3.46407;458.716;79.0815;2.95157E-12;59.8697;16.4725;1.65461E-12;409.549;37.2697 163.536;2498.6;46.5267;1994.77;204.229;2.95158E-12;208.329;67.1945;1.65462E-12;1279.85;133.644 0 Exp 2,1(0.06);Exp 4,4(0.23);Exp 5,1(0.06);Hill,3(0.17);Linear,4(0.23);Poly 2,5(0.28) 2.0507083278759706 41.477864265441895 1.5669527053833008 8.822484970092773 1.6778962711272203 1.72762531042099 74.41708367787012 368.57234338095395 47.665298863728964 227.4989411362716 147.34193217212476 979.7719007690522 DOWN 0.35294117647058826 0.6470588235294118 0.0 GO:0097421 6 liver regeneration 31 34 3 3 3 3 3 3 35 31 2478 0.99858 0.013333 0.013333 8.82 25106;24253;25748 rgn;cebpb;alas2 RGN_9699;CEBPB_32843,CEBPB_8282;ALAS2_8019 24253(-0.009836) 479.67903333333334 620.8109999999999 65.3911 364.8060483643374 359.0494223691168 378.750493367855 301.8449 409.549 37.2697 230.44386694709414 225.96797569691017 241.63795117216912 1136.088 1279.85 133.644 938.854691340465 831.1473412404622 939.2198246367951 0.5 343.10105 752.835;620.8109999999999;65.3911 458.716;409.549;37.2697 1994.77;1279.85;133.644 0 4 0 3 25106;24253;25748 RGN_9699;CEBPB_32843,CEBPB_8282;ALAS2_8019 479.67903333333334 620.8109999999999 364.8060483643374 301.8449 409.549 230.44386694709414 1136.088 1279.85 938.854691340465 752.835;620.8109999999999;65.3911 458.716;409.549;37.2697 1994.77;1279.85;133.644 0 Exp 2,1(0.25);Exp 5,1(0.25);Linear,2(0.5) 1.6655874972781746 6.666785359382629 1.5669527053833008 1.7148494720458984 0.06941979631290382 1.692491590976715 66.86212769203166 892.495938974635 41.073115914593984 562.616684085406 73.67390280029326 2198.5020971997064 DOWN 0.0 1.0 0.0 GO:0071247 6 cellular response to chromate 2 2 1 1 1 1 1 1 37 1 2508 0.99978 0.029622 0.029622 50.0 24567 mt1 MT1A_9255 168.588 168.588 168.588 168.588 103.554 103.554 103.554 103.55400000000002 1208.95 1208.95 1208.95 1208.95 0.0 168.588 0.0 168.588 168.588 103.554 1208.95 0 1 0 1 24567 MT1A_9255 168.588 168.588 103.554 103.554 1208.95 1208.95 168.588 103.554 1208.95 0 Poly 2,1(1) 2.06825590133667 2.06825590133667 2.06825590133667 2.06825590133667 0.0 2.06825590133667 168.588 168.588 103.554 103.554 1208.95 1208.95 DOWN 0.0 1.0 0.0 GO:0042752 4 regulation of circadian rhythm 33 35 3 3 2 3 2 2 36 33 2476 0.98557 0.094812 0.094812 5.71 360243;316351 top2a;npas2 TOP2A_10059;NPAS2_9350 83.6811 83.6811 12.3342 100.89975361327696 84.69347376932222 100.88959548894213 50.748535000000004 50.748535000000004 3.46407 66.87033169255592 51.41947588267935 66.8635994943164 214.61085 214.61085 46.5267 237.70688454995366 216.9958728180737 237.6829533112536 0.5 83.6811 12.3342;155.028 3.46407;98.033 46.5267;382.695 0 2 0 2 360243;316351 TOP2A_10059;NPAS2_9350 83.6811 83.6811 100.89975361327696 50.748535000000004 50.748535000000004 66.87033169255592 214.61085 214.61085 237.70688454995366 12.3342;155.028 3.46407;98.033 46.5267;382.695 0 Hill,1(0.5);Poly 2,1(0.5) 2.109245715594984 4.409249782562256 1.563178539276123 2.846071243286133 0.9071421305402243 2.204624891281128 -56.15882400000001 223.52102399999998 -41.92901639999999 143.42608639999997 -114.83408399999999 544.055784 DOWN 0.0 1.0 0.0 GO:0007346 6 regulation of mitotic cell cycle 146 155 14 13 9 7 4 4 34 151 2358 0.92259 0.19748 0.28784 2.58 360243;304477;24296;25612 top2a;kntc1;cyp1a1;asns TOP2A_10059;KNTC1_8976;CYP1A1_8415;ASNS_8091 57.97534999999999 30.9011 12.3342 68.71563093273126 52.2107319602005 60.02508135558879 37.975135 24.435085 3.46407 43.92912114019165 35.37452591112953 38.69270679452799 130.720475 55.689800000000005 40.2833 160.67104316406605 110.21239227000339 141.23033344350966 12.3342;12.7573;49.0449;157.765 3.46407;9.63387;39.2363;99.5663 46.5267;40.2833;64.8529;371.219 2 2 2 24296;25612 CYP1A1_8415;ASNS_8091 103.40494999999999 103.40494999999999 76.87671996127956 69.40129999999999 69.40129999999999 42.65975210898442 218.03595 218.03595 216.6335468356759 49.0449;157.765 39.2363;99.5663 64.8529;371.219 2 360243;304477 TOP2A_10059;KNTC1_8976 12.54575 12.54575 0.2991768791200032 6.54897 6.54897 4.362707418564761 43.405 43.405 4.414750477659989 12.3342;12.7573 3.46407;9.63387 46.5267;40.2833 0 Exp 5,1(0.25);Hill,1(0.25);Poly 2,2(0.5) 2.9224332249720533 15.08419394493103 1.5997679233551025 8.822484970092773 3.411244953396392 2.330970525741577 -9.365968314076632 125.31666831407662 -5.075403717387822 81.02567371738783 -26.73714730078467 288.17809730078466 CONFLICT 0.5 0.5 0.0 GO:0045664 8 regulation of neuron differentiation 157 165 4 4 3 4 3 3 35 162 2347 0.7707 0.4511 0.73386 1.82 338475;361921;60628 nrep;ect2;cxcr4 NREP_9364;ECT2_8523;CXCR4_8411 48.46996666666721 31.2319 1.65461E-12 59.00861909757974 77.91667696603109 61.26534106333358 31.851333333333887 16.4725 1.65461E-12 41.72352210184659 53.322929641694195 43.21295872689061 90.47450000000056 67.1945 1.65462E-12 104.08573346165097 140.78174443927446 108.05483127867079 114.178;31.2319;1.65461E-12 79.0815;16.4725;1.65461E-12 204.229;67.1945;1.65462E-12 0 3 0 3 338475;361921;60628 NREP_9364;ECT2_8523;CXCR4_8411 48.46996666666721 31.2319 59.00861909757974 31.851333333333887 16.4725 41.72352210184659 90.47450000000056 67.1945 104.08573346165097 114.178;31.2319;1.65461E-12 79.0815;16.4725;1.65461E-12 204.229;67.1945;1.65462E-12 0 Exp 4,1(0.34);Hill,1(0.34);Poly 2,1(0.34) 1.845230596472172 5.570455312728882 1.6721540689468384 2.1538212299346924 0.25974170742865393 1.744480013847351 -18.304571889504473 115.24450522283891 -15.363276632065364 79.06594329873313 -27.30959541645177 208.25859541645286 DOWN 0.0 1.0 0.0 GO:0046685 4 response to arsenic-containing substance 19 20 4 4 4 3 3 3 35 17 2492 0.99983 0.0029328 0.0029328 15.0 360772;24587;24296 zfand2a;nefh;cyp1a1 ZFAND2A_10197;NEFH_33218;CYP1A1_8415 331.6939666666677 49.0449 2.95157E-12 532.6015138054926 351.6116913016436 528.7145236162299 242.2844333333343 39.2363 2.95157E-12 386.1679595847675 257.4126188533517 382.70779188827305 452.31096666666764 64.8529 2.95158E-12 727.9838574232274 479.1273935980513 723.0511938136608 0.0 2.95157E-12 1.0 49.0449 946.037;2.95157E-12;49.0449 687.617;2.95157E-12;39.2363 1292.08;2.95158E-12;64.8529 2 1 2 360772;24296 ZFAND2A_10197;CYP1A1_8415 497.54095 497.54095 634.2691965807618 363.42665 363.42665 458.4743897604805 678.46645 678.46645 867.7806044659012 946.037;49.0449 687.617;39.2363 1292.08;64.8529 1 24587 NEFH_33218 2.95157E-12 2.95157E-12 2.95157E-12 2.95157E-12 2.95158E-12 2.95158E-12 2.95157E-12 2.95157E-12 2.95158E-12 0 Hill,1(0.34);Poly 2,2(0.67) 3.804598875046453 13.82056474685669 2.444005012512207 8.822484970092773 3.6512575100504163 2.554074764251709 -271.00138297148305 934.3893163048183 -194.70575048726676 679.2746171539354 -371.4803183893773 1276.1022517227125 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0048583 4 regulation of response to stimulus 781 832 18 16 11 11 7 7 31 825 1684 0.038882 0.98435 0.07966 0.84 363328;89829;25106;338475;316351;60628;24253 ticam1;socs3;rgn;nrep;npas2;cxcr4;cebpb TICAM1_10015;SOCS3_32863;RGN_9699;NREP_9364;NPAS2_9350;CXCR4_8411;CEBPB_32843,CEBPB_8282 24253(-0.009836) 466.15685714285735 620.8109999999999 1.65461E-12 360.7220004021693 451.4298612052276 356.7124893427914 289.05650000000026 409.549 1.65461E-12 218.85970464070465 279.6683511314135 214.8870878653404 1224.4505714285717 1279.85 1.65462E-12 1032.8501968068515 1198.4740890912392 1045.1553063802132 811.122;809.124;752.835;114.178;155.028;1.65461E-12;620.8109999999999 489.389;488.627;458.716;79.0815;98.033;1.65461E-12;409.549 2362.87;2346.74;1994.77;204.229;382.695;1.65462E-12;1279.85 1 7 1 89829 SOCS3_32863 809.124 809.124 488.627 488.627 2346.74 2346.74 809.124 488.627 2346.74 6 363328;25106;338475;316351;60628;24253 TICAM1_10015;RGN_9699;NREP_9364;NPAS2_9350;CXCR4_8411;CEBPB_32843,CEBPB_8282 408.9956666666669 387.91949999999997 358.7453966771788 255.79475000000033 253.791 219.51354096905908 1037.4023333333337 831.2724999999999 993.0983186506086 811.122;752.835;114.178;155.028;1.65461E-12;620.8109999999999 489.389;458.716;79.0815;98.033;1.65461E-12;409.549 2362.87;1994.77;204.229;382.695;1.65462E-12;1279.85 0 Exp 2,1(0.13);Hill,1(0.13);Linear,4(0.5);Poly 2,2(0.25) 1.6500701332735213 13.215346217155457 1.5415632724761963 1.744480013847351 0.08318035861151007 1.6719605326652527 198.93025960457067 733.3834546811441 126.92296186214125 451.19003813785923 459.30443797475834 1989.5967048823845 DOWN 0.14285714285714285 0.8571428571428571 0.0 GO:0050877 4 nervous system process 155 163 2 2 2 2 2 2 36 161 2348 0.55697 0.71076 1.0 1.23 170945;24253 chrna2;cebpb CHRNA2_32401;CEBPB_32843,CEBPB_8282 24253(-0.009836) 606.4209999999999 606.4209999999999 592.031 20.350533162551223 612.9245625251306 18.153554719770586 402.827 402.827 396.105 9.50634356627263 405.86500884599917 8.480069133161868 1224.24 1224.24 1168.63 78.64441620356651 1249.3729473260958 70.15421667588411 592.031;620.8109999999999 396.105;409.549 1168.63;1279.85 0 3 0 2 170945;24253 CHRNA2_32401;CEBPB_32843,CEBPB_8282 606.4209999999999 606.4209999999999 20.350533162551223 402.827 402.827 9.50634356627263 1224.24 1224.24 78.64441620356651 592.031;620.8109999999999 396.105;409.549 1168.63;1279.85 0 Linear,3(1) 1.699296632019581 5.111884355545044 1.5669527053833008 1.8731646537780762 0.15562391062086714 1.671766996383667 578.2166 634.6253999999999 389.65188000000006 416.00211999999993 1115.2444000000003 1333.2355999999997 DOWN 0.0 1.0 0.0 GO:0060708 5 spongiotrophoblast differentiation 1 1 1 1 1 1 1 1 37 0 2509 1.0 0.01492 0.01492 100.0 89829 socs3 SOCS3_32863 809.124 809.124 809.124 809.124 488.627 488.627 488.627 488.62699999999995 2346.74 2346.74 2346.74 2346.74 0.0 809.124 0.0 809.124 809.124 488.627 2346.74 1 0 1 89829 SOCS3_32863 809.124 809.124 488.627 488.627 2346.74 2346.74 809.124 488.627 2346.74 0 0 Linear,1(1) 1.7404011487960815 1.7404011487960815 1.7404011487960815 1.7404011487960815 0.0 1.7404011487960815 809.124 809.124 488.627 488.627 2346.74 2346.74 UP 1.0 0.0 0.0 GO:0031099 4 regeneration 111 120 12 12 9 10 7 7 31 113 2396 0.99971 0.0016129 0.0016129 5.83 89829;25106;338475;24587;170568;24253;25748 socs3;rgn;nrep;nefh;dmbt1;cebpb;alas2 SOCS3_32863;RGN_9699;NREP_9364;NEFH_33218;DMBT1_32993;CEBPB_32843,CEBPB_8282;ALAS2_8019 24253(-0.009836) 337.85511857142905 114.178 2.95157E-12 370.8426286019679 298.50222665719275 362.5604923305588 210.61996714285758 79.0815 2.95157E-12 228.7742045180852 185.45519160766048 222.50807563735316 852.567468571429 204.229 2.95158E-12 1007.956642745432 764.7750927034413 1011.2680403959022 5.0 752.835 809.124;752.835;114.178;2.95157E-12;2.64673;620.8109999999999;65.3911 488.627;458.716;79.0815;2.95157E-12;1.09657;409.549;37.2697 2346.74;1994.77;204.229;2.95158E-12;8.73928;1279.85;133.644 2 6 2 89829;170568 SOCS3_32863;DMBT1_32993 405.88536500000004 405.88536500000004 570.2655464898143 244.861785 244.861785 344.73607308779344 1177.7396399999998 1177.7396399999998 1653.2161635310308 809.124;2.64673 488.627;1.09657 2346.74;8.73928 5 25106;338475;24587;24253;25748 RGN_9699;NREP_9364;NEFH_33218;CEBPB_32843,CEBPB_8282;ALAS2_8019 310.64302000000055 114.178 348.92120070855765 196.9232400000006 79.0815 219.0318778036948 722.4986000000006 204.229 875.595860481192 752.835;114.178;2.95157E-12;620.8109999999999;65.3911 458.716;79.0815;2.95157E-12;409.549;37.2697 1994.77;204.229;2.95158E-12;1279.85;133.644 0 Exp 2,1(0.13);Exp 4,1(0.13);Exp 5,1(0.13);Hill,1(0.13);Linear,3(0.38);Poly 2,1(0.13) 1.7556747966576502 14.172476172447205 1.5669527053833008 2.444005012512207 0.27683583155402514 1.6926851272583008 63.13105474118629 612.5791824016717 41.14166471124247 380.0982695744728 105.86273804023176 1599.2721991026262 DOWN 0.2857142857142857 0.7142857142857143 0.0 GO:0032501 2 multicellular organismal process 609 640 13 12 10 7 6 6 32 634 1875 0.12267 0.94293 0.25671 0.94 89829;316351;24450;60628;170945;24253 socs3;npas2;hmgcs2;cxcr4;chrna2;cebpb SOCS3_32863;NPAS2_9350;HMGCS2_8812;CXCR4_8411;CHRNA2_32401;CEBPB_32843,CEBPB_8282 24253(-0.009836) 380.5575000000002 373.5295 1.65461E-12 333.76303006938895 348.85228684595256 337.7233727985823 242.03061666666693 247.06900000000002 1.65461E-12 212.1828613238155 216.32174416414523 210.57111445586952 897.7073333333336 775.6625 1.65462E-12 879.2595093990544 876.8682464216503 952.4392002239915 809.124;155.028;106.351;1.65461E-12;592.031;620.8109999999999 488.627;98.033;59.8697;1.65461E-12;396.105;409.549 2346.74;382.695;208.329;1.65462E-12;1168.63;1279.85 1 6 1 89829 SOCS3_32863 809.124 809.124 488.627 488.627 2346.74 2346.74 809.124 488.627 2346.74 5 316351;24450;60628;170945;24253 NPAS2_9350;HMGCS2_8812;CXCR4_8411;CHRNA2_32401;CEBPB_32843,CEBPB_8282 294.8442000000003 155.028 290.08003520528564 192.71134000000035 98.033 195.02314072316608 607.9008000000003 382.695 580.0542262286341 155.028;106.351;1.65461E-12;592.031;620.8109999999999 98.033;59.8697;1.65461E-12;396.105;409.549 382.695;208.329;1.65462E-12;1168.63;1279.85 0 Exp 4,1(0.15);Hill,1(0.15);Linear,4(0.58);Poly 2,1(0.15) 1.7950330045534486 12.738493919372559 1.563178539276123 2.578549861907959 0.3517163900445608 1.7404011487960815 113.49145456610114 647.6235454338994 72.2489674803569 411.812265852977 194.15319782426604 1601.261468842401 DOWN 0.16666666666666666 0.8333333333333334 0.0 GO:0045091 8 regulation of single stranded viral RNA replication via double stranded DNA intermediate 1 1 1 1 1 1 1 1 37 0 2509 1.0 0.01492 0.01492 100.0 360243 top2a TOP2A_10059 12.3342 12.3342 12.3342 12.3342 3.46407 3.46407 3.46407 3.46407 46.5267 46.5267 46.5267 46.5267 0.0 12.3342 0.0 12.3342 12.3342 3.46407 46.5267 0 1 0 1 360243 TOP2A_10059 12.3342 12.3342 3.46407 3.46407 46.5267 46.5267 12.3342 3.46407 46.5267 0 Hill,1(1) 2.8460712432861324 2.846071243286133 2.846071243286133 2.846071243286133 0.0 2.846071243286133 12.3342 12.3342 3.46407 3.46407 46.5267 46.5267 DOWN 0.0 1.0 0.0 GO:0045870 8 positive regulation of single stranded viral RNA replication via double stranded DNA intermediate 1 1 1 1 1 1 1 1 37 0 2509 1.0 0.01492 0.01492 100.0 360243 top2a TOP2A_10059 12.3342 12.3342 12.3342 12.3342 3.46407 3.46407 3.46407 3.46407 46.5267 46.5267 46.5267 46.5267 0.0 12.3342 0.0 12.3342 12.3342 3.46407 46.5267 0 1 0 1 360243 TOP2A_10059 12.3342 12.3342 3.46407 3.46407 46.5267 46.5267 12.3342 3.46407 46.5267 0 Hill,1(1) 2.8460712432861324 2.846071243286133 2.846071243286133 2.846071243286133 0.0 2.846071243286133 12.3342 12.3342 3.46407 3.46407 46.5267 46.5267 DOWN 0.0 1.0 0.0 GO:0070887 4 cellular response to chemical stimulus 594 635 23 20 16 17 13 13 25 622 1887 0.93189 0.12782 0.18802 2.05 360772;363328;89829;24314;114519;24587;24567;24450;361921;24296;60628;24253;25612 zfand2a;ticam1;socs3;nqo1;nfil3;nefh;mt1;hmgcs2;ect2;cyp1a1;cxcr4;cebpb;asns ZFAND2A_10197;TICAM1_10015;SOCS3_32863;NQO1_33055;NFIL3_9304;NEFH_33218;MT1A_9255;HMGCS2_8812;ECT2_8523;CYP1A1_8415;CXCR4_8411;CEBPB_32843,CEBPB_8282;ASNS_8091 24253(-0.009836) 297.0728384615388 121.321 1.65461E-12 357.0807070881745 302.94830879185037 356.3643208781712 192.15504615384648 82.5516 1.65461E-12 236.66288423576455 197.15557011104488 238.3973380458207 731.6331230769233 229.79 1.65462E-12 873.1974279076724 736.625971677345 859.2565007967735 946.037;811.122;809.124;40.5511;121.321;2.95157E-12;168.588;106.351;31.2319;49.0449;1.65461E-12;620.8109999999999;157.765 687.617;489.389;488.627;21.5832;82.5516;2.95157E-12;103.554;59.8697;16.4725;39.2363;1.65461E-12;409.549;99.5663 1292.08;2362.87;2346.74;79.3552;229.79;2.95158E-12;1208.95;208.329;67.1945;64.8529;1.65462E-12;1279.85;371.219 5 9 5 360772;89829;24314;24296;25612 ZFAND2A_10197;SOCS3_32863;NQO1_33055;CYP1A1_8415;ASNS_8091 400.50440000000003 157.765 440.6212573742953 267.32596 99.5663 302.56255932617137 830.8494199999999 371.219 984.0493194950607 946.037;809.124;40.5511;49.0449;157.765 687.617;488.627;21.5832;39.2363;99.5663 1292.08;2346.74;79.3552;64.8529;371.219 8 363328;114519;24587;24567;24450;361921;60628;24253 TICAM1_10015;NFIL3_9304;NEFH_33218;MT1A_9255;HMGCS2_8812;ECT2_8523;CXCR4_8411;CEBPB_32843,CEBPB_8282 232.42811250000057 113.836 308.58414974712827 145.17322500000057 71.21065 192.73363428009492 669.6229375000005 219.0595 861.5841930223827 811.122;121.321;2.95157E-12;168.588;106.351;31.2319;1.65461E-12;620.8109999999999 489.389;82.5516;2.95157E-12;103.554;59.8697;16.4725;1.65461E-12;409.549 2362.87;229.79;2.95158E-12;1208.95;208.329;67.1945;1.65462E-12;1279.85 0 Exp 4,3(0.22);Hill,2(0.15);Linear,4(0.29);Poly 2,5(0.36) 2.2165145997938605 35.22427034378052 1.5415632724761963 8.822484970092773 1.8573174430394708 2.111038565635681 102.96155493728594 491.1841219857917 63.503636795535385 320.80645551215764 256.9575941652472 1206.3086519885996 DOWN 0.38461538461538464 0.6153846153846154 0.0 GO:0033993 5 response to lipid 414 443 18 17 14 11 9 9 29 434 2075 0.89043 0.20286 0.28481 2.03 363328;89829;24314;24587;24450;266674;24296;24253;25748 ticam1;socs3;nqo1;nefh;hmgcs2;cyp4a8;cyp1a1;cebpb;alas2 TICAM1_10015;SOCS3_32863;NQO1_33055;NEFH_33218;HMGCS2_8812;CYP4A8_32747;CYP1A1_8415;CEBPB_32843,CEBPB_8282;ALAS2_8019 24253(-0.009836) 286.5615222222225 76.6586 2.95157E-12 350.7959085881586 257.0433560483408 337.5325422219602 178.14883333333364 57.8156 2.95157E-12 215.2546855959874 158.28185910799934 206.33741852876847 732.0581222222226 133.644 2.95158E-12 999.355080883586 662.0374890868982 975.4442055442629 811.122;809.124;40.5511;2.95157E-12;106.351;76.6586;49.0449;620.8109999999999;65.3911 489.389;488.627;21.5832;2.95157E-12;59.8697;57.8156;39.2363;409.549;37.2697 2362.87;2346.74;79.3552;2.95158E-12;208.329;112.882;64.8529;1279.85;133.644 4 6 4 89829;24314;266674;24296 SOCS3_32863;NQO1_33055;CYP4A8_32747;CYP1A1_8415 243.84465 62.85175 377.16801248368967 151.815525 48.52595 225.02777307715263 650.9575249999999 96.1186 1130.700567865331 809.124;40.5511;76.6586;49.0449 488.627;21.5832;57.8156;39.2363 2346.74;79.3552;112.882;64.8529 5 363328;24587;24450;24253;25748 TICAM1_10015;NEFH_33218;HMGCS2_8812;CEBPB_32843,CEBPB_8282;ALAS2_8019 320.73502000000053 106.351 368.9705145716952 199.21548000000058 59.8697 231.17707005671366 796.9386000000006 208.329 1013.2715195749846 811.122;2.95157E-12;106.351;620.8109999999999;65.3911 489.389;2.95157E-12;59.8697;409.549;37.2697 2362.87;2.95158E-12;208.329;1279.85;133.644 0 Exp 4,2(0.2);Exp 5,1(0.1);Hill,1(0.1);Linear,4(0.4);Poly 2,2(0.2) 2.2049627629731527 26.23165214061737 1.5415632724761963 8.822484970092773 2.2203220510241413 1.7268086671829224 57.37486194462562 515.7481824998196 37.515772077288574 318.7818945893788 79.14613604494639 1384.9701083994987 CONFLICT 0.4444444444444444 0.5555555555555556 0.0 GO:0045944 9 positive regulation of transcription by RNA polymerase II 241 260 6 6 4 5 3 3 35 257 2252 0.44665 0.76139 1.0 1.15 360243;316351;24253 top2a;npas2;cebpb TOP2A_10059;NPAS2_9350;CEBPB_32843,CEBPB_8282 24253(-0.009836) 262.7244 155.028 12.3342 318.2135917340426 204.00324741772462 283.7762887846695 170.34869 98.033 3.46407 212.48155651352025 131.1190760051769 189.45443637772422 569.6905666666667 382.695 46.5267 637.5712486032155 453.5277508689757 571.0674674842106 12.3342;155.028;620.8109999999999 3.46407;98.033;409.549 46.5267;382.695;1279.85 0 4 0 3 360243;316351;24253 TOP2A_10059;NPAS2_9350;CEBPB_32843,CEBPB_8282 262.7244 155.028 318.2135917340426 170.34869 98.033 212.48155651352025 569.6905666666667 382.695 637.5712486032155 12.3342;155.028;620.8109999999999 3.46407;98.033;409.549 46.5267;382.695;1279.85 0 Hill,1(0.25);Linear,2(0.5);Poly 2,1(0.25) 1.8476576170770476 7.647969484329224 1.563178539276123 2.846071243286133 0.6247492911324958 1.6193598508834839 -97.36817758099653 622.8169775809964 -70.0968263477867 410.79420634778666 -151.78922007025267 1291.170353403586 DOWN 0.0 1.0 0.0 GO:0030182 5 neuron differentiation 63 68 3 2 2 2 2 2 36 66 2443 0.92093 0.26959 0.26959 2.94 360243;24253 top2a;cebpb TOP2A_10059;CEBPB_32843,CEBPB_8282 24253(-0.009836) 316.57259999999997 316.57259999999997 12.3342 430.25807147469055 235.87776748397596 414.8477986919319 206.50653499999999 206.50653499999999 3.46407 287.14540774066444 152.65245968664158 276.86090791377296 663.1883499999999 663.1883499999999 46.5267 872.0912688253707 499.6277719605249 840.8561445242761 12.3342;620.8109999999999 3.46407;409.549 46.5267;1279.85 0 3 0 2 360243;24253 TOP2A_10059;CEBPB_32843,CEBPB_8282 316.57259999999997 316.57259999999997 430.25807147469055 206.50653499999999 206.50653499999999 287.14540774066444 663.1883499999999 663.1883499999999 872.0912688253707 12.3342;620.8109999999999 3.46407;409.549 46.5267;1279.85 0 Hill,1(0.34);Linear,2(0.67) 1.9535557117504738 6.084790945053101 1.5669527053833008 2.846071243286133 0.7101784674640776 1.671766996383667 -279.73466399999984 912.8798639999998 -191.45669639999994 604.4697663999999 -545.4684839999999 1871.8451839999998 DOWN 0.0 1.0 0.0 GO:0098754 2 detoxification 44 58 6 6 5 4 3 3 35 55 2454 0.98996 0.053849 0.053849 5.17 24314;24567;26760 nqo1;mt1;akr7a3 NQO1_33055;MT1A_9255;AKR7A3_8015 90.64476666666667 62.7952 40.5511 68.41096924502192 87.10935281096963 67.34754218568905 57.962066666666665 48.749 21.5832 41.7548016545802 55.61784447600391 41.43412170818524 458.6507333333334 87.647 79.3552 649.791451665235 428.63494310479916 635.8150261349756 1.5 115.6916 40.5511;168.588;62.7952 21.5832;103.554;48.749 79.3552;1208.95;87.647 2 1 2 24314;26760 NQO1_33055;AKR7A3_8015 51.67315 51.67315 15.728953951391693 35.1661 35.1661 19.209121396357506 83.50110000000001 83.50110000000001 5.863188008242397 40.5511;62.7952 21.5832;48.749 79.3552;87.647 1 24567 MT1A_9255 168.588 168.588 103.554 103.554 1208.95 1208.95 168.588 103.554 1208.95 0 Exp 4,1(0.34);Poly 2,2(0.67) 2.127830467830005 6.453655242919922 1.8055906295776367 2.5798087120056152 0.3937200702381496 2.06825590133667 13.230467308758918 168.0590660245744 10.712060555213306 105.21207277812005 -276.65751495730717 1193.958981623974 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0050794 4 regulation of cellular process 1555 1680 61 57 41 40 28 28 10 1652 857 0.88378 0.20211 0.38925 1.67 24522;360772;362246;360243;363328;89829;299276;25106;363140;338475;24314;316351;114519;24587;24567;304477;315740;361308;499271;83928;361921;170568;24296;60628;170945;24253;25612;54223 zfp354a;zfand2a;tp53inp2;top2a;ticam1;socs3;serpina3m;rgn;rassf1;nrep;nqo1;npas2;nfil3;nefh;mt1;kntc1;kif23;kif20a;itgax;fetub;ect2;dmbt1;cyp1a1;cxcr4;chrna2;cebpb;asns;adcy4 ZFP354A_10203;ZFAND2A_10197;TP53INP2_32755;TOP2A_10059;TICAM1_10015;SOCS3_32863;SERPINA3M_9809;RGN_9699;RASSF1_32475;NREP_9364;NQO1_33055;NPAS2_9350;NFIL3_9304;NEFH_33218;MT1A_9255;KNTC1_8976;KIF23_32798;KIF20A_8961;ITGAX_32980;FETUB_33027;ECT2_8523;DMBT1_32993;CYP1A1_8415;CXCR4_8411;CHRNA2_32401;CEBPB_32843,CEBPB_8282;ASNS_8091;ADCY4_7988 24253(-0.009836) 326.8161260714287 151.666 1.65461E-12 343.93130706767306 340.0804276258764 350.2767669137456 208.7965282142859 96.60849999999999 1.65461E-12 221.9486210681044 219.01728775514073 228.38373379075088 765.1538385714287 356.102 1.65462E-12 841.767700606419 764.9612199139974 819.970476174409 99.2226;946.037;827.265;12.3342;811.122;809.124;466.86;752.835;903.848;114.178;40.5511;155.028;121.321;2.95157E-12;168.588;12.7573;10.3381;35.2747;148.304;545.901;31.2319;2.64673;49.0449;1.65461E-12;592.031;620.8109999999999;157.765;716.432 71.0566;687.617;495.492;3.46407;489.389;488.627;296.126;458.716;608.514;79.0815;21.5832;98.033;82.5516;2.95157E-12;103.554;9.63387;4.23628;15.546;95.184;382.164;16.4725;1.09657;39.2363;1.65461E-12;396.105;409.549;99.5663;393.708 163.536;1292.08;2498.6;46.5267;2362.87;2346.74;918.743;1994.77;1171.72;204.229;79.3552;382.695;229.79;2.95158E-12;1208.95;40.2833;21.7065;96.5441;340.985;976.618;67.1945;8.73928;64.8529;1.65462E-12;1168.63;1279.85;371.219;2087.08 8 21 8 360772;89829;363140;24314;83928;170568;24296;25612 ZFAND2A_10197;SOCS3_32863;RASSF1_32475;NQO1_33055;FETUB_33027;DMBT1_32993;CYP1A1_8415;ASNS_8091 431.86471625 351.83299999999997 414.2991139689792 291.05054625 240.86515 283.38482252230745 788.9155475 673.9185 817.0199306021129 946.037;809.124;903.848;40.5511;545.901;2.64673;49.0449;157.765 687.617;488.627;608.514;21.5832;382.164;1.09657;39.2363;99.5663 1292.08;2346.74;1171.72;79.3552;976.618;8.73928;64.8529;371.219 20 24522;362246;360243;363328;299276;25106;338475;316351;114519;24587;24567;304477;315740;361308;499271;361921;60628;170945;24253;54223 ZFP354A_10203;TP53INP2_32755;TOP2A_10059;TICAM1_10015;SERPINA3M_9809;RGN_9699;NREP_9364;NPAS2_9350;NFIL3_9304;NEFH_33218;MT1A_9255;KNTC1_8976;KIF23_32798;KIF20A_8961;ITGAX_32980;ECT2_8523;CXCR4_8411;CHRNA2_32401;CEBPB_32843,CEBPB_8282;ADCY4_7988 284.79669000000024 134.8125 313.61185246322316 175.89492100000024 88.86779999999999 190.86056279486422 755.6491550000003 285.3875 872.1568113614962 99.2226;827.265;12.3342;811.122;466.86;752.835;114.178;155.028;121.321;2.95157E-12;168.588;12.7573;10.3381;35.2747;148.304;31.2319;1.65461E-12;592.031;620.8109999999999;716.432 71.0566;495.492;3.46407;489.389;296.126;458.716;79.0815;98.033;82.5516;2.95157E-12;103.554;9.63387;4.23628;15.546;95.184;16.4725;1.65461E-12;396.105;409.549;393.708 163.536;2498.6;46.5267;2362.87;918.743;1994.77;204.229;382.695;229.79;2.95158E-12;1208.95;40.2833;21.7065;96.5441;340.985;67.1945;1.65462E-12;1168.63;1279.85;2087.08 0 Exp 2,4(0.14);Exp 4,4(0.14);Exp 5,2(0.07);Hill,3(0.11);Linear,6(0.21);Poly 2,10(0.35) 1.9623094946421331 61.838245034217834 1.5054508447647095 8.822484970092773 1.3415545092343044 1.744480013847351 199.42218714876515 454.21006499409225 126.58560848909778 291.007447939474 453.3587189226525 1076.948958220205 DOWN 0.2857142857142857 0.7142857142857143 0.0 GO:0009987 2 cellular process 2111 2325 83 78 55 53 36 36 2 2289 220 0.85734 0.34311 0.76891 1.55 24522;360772;362246;360243;363328;89829;25044;25106;363140;304951;338475;24314;114519;24587;24567;291885;304477;315740;361308;499271;24450;60671;83928;361921;170568;266674;266684;29277;24296;60628;170945;24253;25612;25748;26760;54223 zfp354a;zfand2a;tp53inp2;top2a;ticam1;socs3;sds;rgn;rassf1;nuf2;nrep;nqo1;nfil3;nefh;mt1;mcm5;kntc1;kif23;kif20a;itgax;hmgcs2;gulo;fetub;ect2;dmbt1;cyp4a8;cyp2d1;cyp2c11;cyp1a1;cxcr4;chrna2;cebpb;asns;alas2;akr7a3;adcy4 ZFP354A_10203;ZFAND2A_10197;TP53INP2_32755;TOP2A_10059;TICAM1_10015;SOCS3_32863;SDS_9798;RGN_9699;RASSF1_32475;NUF2_33136;NREP_9364;NQO1_33055;NFIL3_9304;NEFH_33218;MT1A_9255;MCM5_9209;KNTC1_8976;KIF23_32798;KIF20A_8961;ITGAX_32980;HMGCS2_8812;GULO_8772;FETUB_33027;ECT2_8523;DMBT1_32993;CYP4A8_32747;CYP2D1_32660;CYP2C11_32593;CYP1A1_8415;CXCR4_8411;CHRNA2_32401;CEBPB_32843,CEBPB_8282;ASNS_8091;ALAS2_8019;AKR7A3_8015;ADCY4_7988 24253(-0.009836) 276.48258750000014 117.7495 1.65461E-12 321.7543952340129 294.009518752852 336.57871929322914 177.34099250000014 80.81655 1.65461E-12 207.97513231978115 189.6450902921144 219.77663031389275 650.9520966666668 219.0595 1.65462E-12 787.6980654643488 664.4644676081515 790.7087503980003 99.2226;946.037;827.265;12.3342;811.122;809.124;553.681;752.835;903.848;9.55312;114.178;40.5511;121.321;2.95157E-12;168.588;12.5006;12.7573;10.3381;35.2747;148.304;106.351;193.989;545.901;31.2319;2.64673;76.6586;126.747;216.743;49.0449;1.65461E-12;592.031;620.8109999999999;157.765;65.3911;62.7952;716.432 71.0566;687.617;495.492;3.46407;489.389;488.627;377.484;458.716;608.514;4.27871;79.0815;21.5832;82.5516;2.95157E-12;103.554;9.67503;9.63387;4.23628;15.546;95.184;59.8697;112.274;382.164;16.4725;1.09657;57.8156;85.1532;139.563;39.2363;1.65461E-12;396.105;409.549;99.5663;37.2697;48.749;393.708 163.536;1292.08;2498.6;46.5267;2362.87;2346.74;1035.66;1994.77;1171.72;37.8054;204.229;79.3552;229.79;2.95158E-12;1208.95;36.0856;40.2833;21.7065;96.5441;340.985;208.329;1039.83;976.618;67.1945;8.73928;112.882;250.579;368.944;64.8529;1.65462E-12;1168.63;1279.85;371.219;133.644;87.647;2087.08 13 24 13 360772;89829;25044;363140;24314;60671;83928;170568;266674;266684;24296;25612;26760 ZFAND2A_10197;SOCS3_32863;SDS_9798;RASSF1_32475;NQO1_33055;GULO_8772;FETUB_33027;DMBT1_32993;CYP4A8_32747;CYP2D1_32660;CYP1A1_8415;ASNS_8091;AKR7A3_8015 343.7529638461538 157.765 356.77759365146005 231.52924384615386 99.5663 243.41777954961023 679.840183076923 371.219 700.0256168610623 946.037;809.124;553.681;903.848;40.5511;193.989;545.901;2.64673;76.6586;126.747;49.0449;157.765;62.7952 687.617;488.627;377.484;608.514;21.5832;112.274;382.164;1.09657;57.8156;85.1532;39.2363;99.5663;48.749 1292.08;2346.74;1035.66;1171.72;79.3552;1039.83;976.618;8.73928;112.882;250.579;64.8529;371.219;87.647 23 24522;362246;360243;363328;25106;304951;338475;114519;24587;24567;291885;304477;315740;361308;499271;24450;361921;29277;60628;170945;24253;25748;54223 ZFP354A_10203;TP53INP2_32755;TOP2A_10059;TICAM1_10015;RGN_9699;NUF2_33136;NREP_9364;NFIL3_9304;NEFH_33218;MT1A_9255;MCM5_9209;KNTC1_8976;KIF23_32798;KIF20A_8961;ITGAX_32980;HMGCS2_8812;ECT2_8523;CYP2C11_32593;CXCR4_8411;CHRNA2_32401;CEBPB_32843,CEBPB_8282;ALAS2_8019;ADCY4_7988 238.46020086956543 106.351 301.80088819662467 146.71285043478284 71.0566 183.7862749391098 634.6240478260872 204.229 847.9648741529695 99.2226;827.265;12.3342;811.122;752.835;9.55312;114.178;121.321;2.95157E-12;168.588;12.5006;12.7573;10.3381;35.2747;148.304;106.351;31.2319;216.743;1.65461E-12;592.031;620.8109999999999;65.3911;716.432 71.0566;495.492;3.46407;489.389;458.716;4.27871;79.0815;82.5516;2.95157E-12;103.554;9.67503;9.63387;4.23628;15.546;95.184;59.8697;16.4725;139.563;1.65461E-12;396.105;409.549;37.2697;393.708 163.536;2498.6;46.5267;2362.87;1994.77;37.8054;204.229;229.79;2.95158E-12;1208.95;36.0856;40.2833;21.7065;96.5441;340.985;208.329;67.1945;368.944;1.65462E-12;1168.63;1279.85;133.644;2087.08 0 Exp 2,4(0.11);Exp 4,5(0.14);Exp 5,5(0.14);Hill,3(0.09);Linear,7(0.19);Poly 2,13(0.36) 2.0111913765991924 83.0844898223877 1.5054508447647095 8.822484970092773 1.580643211227579 1.7765510082244873 171.37615172355595 381.5890232764443 109.4024492755383 245.279535724462 393.63739528164615 908.2667980516874 DOWN 0.3611111111111111 0.6388888888888888 0.0 GO:0007093 7 mitotic cell cycle checkpoint 35 38 7 6 5 3 2 2 36 36 2473 0.98196 0.10898 0.10898 5.26 360243;304477 top2a;kntc1 TOP2A_10059;KNTC1_8976 12.54575 12.54575 12.3342 0.2991768791200032 12.535288540084387 0.2988108443695663 6.54897 6.54897 3.46407 4.362707418564761 6.396417139240506 4.357369765047279 43.405 43.405 40.2833 4.414750477659989 43.55937267510548 4.409349150879514 0.5 12.54575 12.3342;12.7573 3.46407;9.63387 46.5267;40.2833 0 2 0 2 360243;304477 TOP2A_10059;KNTC1_8976 12.54575 12.54575 0.2991768791200032 6.54897 6.54897 4.362707418564761 43.405 43.405 4.414750477659989 12.3342;12.7573 3.46407;9.63387 46.5267;40.2833 0 Exp 5,1(0.5);Hill,1(0.5) 2.273344417958055 4.661941051483154 1.8158698081970215 2.846071243286133 0.7284624207396235 2.330970525741577 12.131111999999998 12.960388000000002 0.5025660000000016 12.595374 37.286468 49.523532 DOWN 0.0 1.0 0.0 GO:1901423 6 response to benzene 3 3 1 1 1 1 1 1 37 2 2507 0.99936 0.044111 0.044111 33.33 25748 alas2 ALAS2_8019 65.3911 65.3911 65.3911 65.3911 37.2697 37.2697 37.2697 37.2697 133.644 133.644 133.644 133.644 0.0 65.3911 0.0 65.3911 65.3911 37.2697 133.644 0 1 0 1 25748 ALAS2_8019 65.3911 65.3911 37.2697 37.2697 133.644 133.644 65.3911 37.2697 133.644 0 Exp 5,1(1) 1.7132161855697632 1.7132161855697632 1.7132161855697632 1.7132161855697632 0.0 1.7132161855697632 65.3911 65.3911 37.2697 37.2697 133.644 133.644 DOWN 0.0 1.0 0.0 GO:0044255 4 cellular lipid metabolic process 218 243 9 9 6 8 6 6 32 237 2272 0.93607 0.14797 0.16947 2.47 89829;24450;266674;266684;29277;24296 socs3;hmgcs2;cyp4a8;cyp2d1;cyp2c11;cyp1a1 SOCS3_32863;HMGCS2_8812;CYP4A8_32747;CYP2D1_32660;CYP2C11_32593;CYP1A1_8415 230.77808333333334 116.549 49.0449 289.05546641533294 231.31876517403043 305.1054025301035 145.04413333333332 72.51145 39.2363 171.88656241886588 143.77208331297058 182.12338992039633 558.72115 229.454 64.8529 882.4320273014205 578.5301390225884 926.2490205489514 809.124;106.351;76.6586;126.747;216.743;49.0449 488.627;59.8697;57.8156;85.1532;139.563;39.2363 2346.74;208.329;112.882;250.579;368.944;64.8529 4 2 4 89829;266674;266684;24296 SOCS3_32863;CYP4A8_32747;CYP2D1_32660;CYP1A1_8415 265.393625 101.7028 363.9108351379532 167.70802500000002 71.4844 214.7755548184255 693.763475 181.7305 1104.7919367354662 809.124;76.6586;126.747;49.0449 488.627;57.8156;85.1532;39.2363 2346.74;112.882;250.579;64.8529 2 24450;29277 HMGCS2_8812;CYP2C11_32593 161.547 161.547 78.05893178874537 99.71634999999999 99.71634999999999 56.35167284513388 288.6365 288.6365 113.5719556602773 106.351;216.743 59.8697;139.563 208.329;368.944 0 Exp 2,1(0.17);Exp 4,1(0.17);Linear,1(0.17);Poly 2,3(0.5) 3.0564321831452474 24.634721755981445 1.5671749114990234 8.822484970092773 3.495007187200679 2.1594755053520203 -0.5144606927234179 462.0706273593901 7.50623862135771 282.582028045309 -147.3715285288771 1264.813828528877 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0051928 7 positive regulation of calcium ion transport 41 45 2 2 2 2 2 2 36 43 2466 0.97174 0.14399 0.14399 4.44 25106;60628 rgn;cxcr4 RGN_9699;CXCR4_8411 376.41750000000087 376.41750000000087 1.65461E-12 532.3347336145733 398.0891412287488 531.4517367978053 229.35800000000083 229.35800000000083 1.65461E-12 324.36119423876715 242.56292349304556 323.82316828646606 997.3850000000008 997.3850000000008 1.65462E-12 1410.5153939074883 1054.8078612828444 1408.175737063446 752.835;1.65461E-12 458.716;1.65461E-12 1994.77;1.65462E-12 0 2 0 2 25106;60628 RGN_9699;CXCR4_8411 376.41750000000087 376.41750000000087 532.3347336145733 229.35800000000083 229.35800000000083 324.36119423876715 997.3850000000008 997.3850000000008 1410.5153939074883 752.835;1.65461E-12 458.716;1.65461E-12 1994.77;1.65462E-12 0 Exp 2,1(0.5);Hill,1(0.5) 1.729601292419947 3.4593294858932495 1.7148494720458984 1.744480013847351 0.020951957038038618 1.7296647429466248 -361.3607999999975 1114.1957999999993 -220.1836799999975 678.8996799999992 -957.4895999999975 2952.259599999999 DOWN 0.0 1.0 0.0 GO:0098542 4 defense response to other organism 155 169 6 5 5 4 4 4 34 165 2344 0.89684 0.24241 0.31458 2.37 363328;499271;170568;24253 ticam1;itgax;dmbt1;cebpb TICAM1_10015;ITGAX_32980;DMBT1_32993;CEBPB_32843,CEBPB_8282 24253(-0.009836) 395.7209325 384.55749999999995 2.64673 382.5118963404993 304.00164881111397 364.3168041493886 248.8046425 252.36649999999997 1.09657 237.12034393640266 190.75421946956078 225.4353584635259 998.1110699999999 810.4175 8.73928 1057.1368521331156 771.0728801472729 1004.319524711928 811.122;148.304;2.64673;620.8109999999999 489.389;95.184;1.09657;409.549 2362.87;340.985;8.73928;1279.85 1 4 1 170568 DMBT1_32993 2.64673 2.64673 1.09657 1.09657 8.73928 8.73928 2.64673 1.09657 8.73928 3 363328;499271;24253 TICAM1_10015;ITGAX_32980;CEBPB_32843,CEBPB_8282 526.7456666666666 620.8109999999999 341.2742892195857 331.37399999999997 409.549 208.40559847326557 1327.9016666666666 1279.85 1011.7986263621497 811.122;148.304;620.8109999999999 489.389;95.184;409.549 2362.87;340.985;1279.85 0 Exp 4,1(0.2);Linear,3(0.6);Poly 2,1(0.2) 1.6555110733470884 8.296706318855286 1.5415632724761963 1.8672927618026733 0.12836450378188016 1.6491305828094482 20.859274086310677 770.5825909136893 16.426705442325385 481.1825795576746 -37.883045090453265 2034.1051850904532 DOWN 0.25 0.75 0.0 GO:0033574 5 response to testosterone 28 31 2 2 2 2 2 2 36 29 2480 0.98967 0.076874 0.076874 6.45 24450;266674 hmgcs2;cyp4a8 HMGCS2_8812;CYP4A8_32747 91.5048 91.5048 76.6586 20.995697389703526 102.1567946098756 14.624955744971215 58.842650000000006 58.842650000000006 57.8156 1.4524680392349714 59.579547728986064 1.0117444731894971 160.6055 160.6055 112.882 67.49122094391242 194.84661656615154 47.01230452877669 0.5 91.5048 106.351;76.6586 59.8697;57.8156 208.329;112.882 1 1 1 266674 CYP4A8_32747 76.6586 76.6586 57.8156 57.8156 112.882 112.882 76.6586 57.8156 112.882 1 24450 HMGCS2_8812 106.351 106.351 59.8697 59.8697 208.329 208.329 106.351 59.8697 208.329 0 Exp 4,1(0.5);Poly 2,1(0.5) 2.0139040502985286 4.151453137397766 1.5729032754898071 2.578549861907959 0.7110995207333786 2.075726568698883 62.40624800000001 120.603352 56.82963200000001 60.855668 67.06744000000002 254.14355999999998 CONFLICT 0.5 0.5 0.0 GO:0042493 4 response to drug 436 472 23 21 19 18 15 15 23 457 2052 0.9994 0.001949 0.0023381 3.18 24522;360243;89829;25044;24314;316351;24587;24450;361921;266684;24296;60628;170945;25612;25748 zfp354a;top2a;socs3;sds;nqo1;npas2;nefh;hmgcs2;ect2;cyp2d1;cyp1a1;cxcr4;chrna2;asns;alas2 ZFP354A_10203;TOP2A_10059;SOCS3_32863;SDS_9798;NQO1_33055;NPAS2_9350;NEFH_33218;HMGCS2_8812;ECT2_8523;CYP2D1_32660;CYP1A1_8415;CXCR4_8411;CHRNA2_32401;ASNS_8091;ALAS2_8019 186.56685333333365 99.2226 1.65461E-12 251.45781131248518 168.98902644163906 240.70254807387468 119.59470466666697 59.8697 1.65461E-12 160.95527040969344 106.10972975616173 149.96756474049386 421.26408666666697 163.536 1.65462E-12 640.076023326363 401.83664673219783 665.2306305621482 99.2226;12.3342;809.124;553.681;40.5511;155.028;2.95157E-12;106.351;31.2319;126.747;49.0449;1.65461E-12;592.031;157.765;65.3911 71.0566;3.46407;488.627;377.484;21.5832;98.033;2.95157E-12;59.8697;16.4725;85.1532;39.2363;1.65461E-12;396.105;99.5663;37.2697 163.536;46.5267;2346.74;1035.66;79.3552;382.695;2.95158E-12;208.329;67.1945;250.579;64.8529;1.65462E-12;1168.63;371.219;133.644 6 9 6 89829;25044;24314;266684;24296;25612 SOCS3_32863;SDS_9798;NQO1_33055;CYP2D1_32660;CYP1A1_8415;ASNS_8091 289.4855 142.256 317.3129559399427 185.27499999999998 92.35974999999999 197.21024261475873 691.4010166666667 310.899 885.7386291362986 809.124;553.681;40.5511;126.747;49.0449;157.765 488.627;377.484;21.5832;85.1532;39.2363;99.5663 2346.74;1035.66;79.3552;250.579;64.8529;371.219 9 24522;360243;316351;24587;24450;361921;60628;170945;25748 ZFP354A_10203;TOP2A_10059;NPAS2_9350;NEFH_33218;HMGCS2_8812;ECT2_8523;CXCR4_8411;CHRNA2_32401;ALAS2_8019 117.95442222222272 65.3911 185.69948634393637 75.80784111111163 37.2697 125.04697922461331 241.17280000000054 133.644 367.9942617933359 99.2226;12.3342;155.028;2.95157E-12;106.351;31.2319;1.65461E-12;592.031;65.3911 71.0566;3.46407;98.033;2.95157E-12;59.8697;16.4725;1.65461E-12;396.105;37.2697 163.536;46.5267;382.695;2.95158E-12;208.329;67.1945;1.65462E-12;1168.63;133.644 0 Exp 4,3(0.2);Exp 5,1(0.07);Hill,3(0.2);Linear,3(0.2);Poly 2,5(0.34) 2.1472653145259253 36.60491383075714 1.5452189445495605 8.822484970092773 1.8175608947301338 1.8335704803466797 59.31164304302945 313.82206362363786 38.140099313942585 201.04931001939138 97.34092625644286 745.1872470768913 DOWN 0.4 0.6 0.0 GO:0035556 5 intracellular signal transduction 318 334 12 11 9 9 7 7 31 327 2182 0.88511 0.22302 0.33016 2.1 89829;363140;24567;361921;60628;24253;54223 socs3;rassf1;mt1;ect2;cxcr4;cebpb;adcy4 SOCS3_32863;RASSF1_32475;MT1A_9255;ECT2_8523;CXCR4_8411;CEBPB_32843,CEBPB_8282;ADCY4_7988 24253(-0.009836) 464.2907000000002 620.8109999999999 1.65461E-12 385.3008195772014 603.4213275842603 351.0529951369076 288.6320714285717 393.708 1.65461E-12 244.8188008719283 379.4886247106646 229.6135954252441 1165.9335000000003 1208.95 1.65462E-12 896.688728347663 1423.579497826455 733.4343112454256 809.124;903.848;168.588;31.2319;1.65461E-12;620.8109999999999;716.432 488.627;608.514;103.554;16.4725;1.65461E-12;409.549;393.708 2346.74;1171.72;1208.95;67.1945;1.65462E-12;1279.85;2087.08 2 6 2 89829;363140 SOCS3_32863;RASSF1_32475 856.486 856.486 66.9799827411141 548.5705 548.5705 84.7729106761117 1759.23 1759.23 830.8646100298168 809.124;903.848 488.627;608.514 2346.74;1171.72 5 24567;361921;60628;24253;54223 MT1A_9255;ECT2_8523;CXCR4_8411;CEBPB_32843,CEBPB_8282;ADCY4_7988 307.41258000000033 168.588 337.47814075704474 184.65670000000034 103.554 202.01526091040705 928.6149000000003 1208.95 887.1817724852382 168.588;31.2319;1.65461E-12;620.8109999999999;716.432 103.554;16.4725;1.65461E-12;409.549;393.708 1208.95;67.1945;1.65462E-12;1279.85;2087.08 0 Exp 2,1(0.13);Exp 4,1(0.13);Hill,1(0.13);Linear,3(0.38);Poly 2,2(0.25) 1.878808969255579 15.250954866409302 1.5669527053833008 2.6542086601257324 0.3656457141375733 1.7424405813217163 178.85585840582053 749.7255415941798 107.2677656821254 469.996377175018 501.6571939800524 1830.2098060199478 DOWN 0.2857142857142857 0.7142857142857143 0.0 GO:0038160 9 CXCL12-activated CXCR4 signaling pathway 1 1 1 1 1 1 1 1 37 0 2509 1.0 0.01492 0.01492 100.0 60628 cxcr4 CXCR4_8411 1.65461E-12 1.65461E-12 1.65461E-12 1.65461E-12 1.65461E-12 1.65461E-12 1.65461E-12 1.65461E-12 1.65462E-12 1.65462E-12 1.65462E-12 1.65462E-12 0.0 1.65461E-12 0.0 1.65461E-12 1.65461E-12 1.65461E-12 1.65462E-12 0 1 0 1 60628 CXCR4_8411 1.65461E-12 1.65461E-12 1.65461E-12 1.65461E-12 1.65462E-12 1.65462E-12 1.65461E-12 1.65461E-12 1.65462E-12 0 Hill,1(1) 1.744480013847351 1.744480013847351 1.744480013847351 1.744480013847351 0.0 1.744480013847351 1.65461E-12 1.65461E-12 1.65461E-12 1.65461E-12 1.65462E-12 1.65462E-12 DOWN 0.0 1.0 0.0 GO:0031667 5 response to nutrient levels 239 256 12 11 9 9 7 7 31 249 2260 0.96843 0.080146 0.097457 2.73 24522;89829;25044;24314;24450;24296;25612 zfp354a;socs3;sds;nqo1;hmgcs2;cyp1a1;asns ZFP354A_10203;SOCS3_32863;SDS_9798;NQO1_33055;HMGCS2_8812;CYP1A1_8415;ASNS_8091 259.39137142857146 106.351 40.5511 300.09786204942503 225.22433308929186 297.6169442715784 165.34615714285715 71.0566 21.5832 187.27308262218622 141.22570338693123 183.19994040096915 609.9560142857143 208.329 64.8529 836.052986315286 547.948292350325 853.1879886806647 99.2226;809.124;553.681;40.5511;106.351;49.0449;157.765 71.0566;488.627;377.484;21.5832;59.8697;39.2363;99.5663 163.536;2346.74;1035.66;79.3552;208.329;64.8529;371.219 5 2 5 89829;25044;24314;24296;25612 SOCS3_32863;SDS_9798;NQO1_33055;CYP1A1_8415;ASNS_8091 322.0332 157.765 343.3864356588725 205.29935999999998 99.5663 213.559212607752 779.56542 371.219 960.4004028616877 809.124;553.681;40.5511;49.0449;157.765 488.627;377.484;21.5832;39.2363;99.5663 2346.74;1035.66;79.3552;64.8529;371.219 2 24522;24450 ZFP354A_10203;HMGCS2_8812 102.7868 102.7868 5.040539979010178 65.46315 65.46315 7.910332850455866 185.9325 185.9325 31.673434049689142 99.2226;106.351 71.0566;59.8697 163.536;208.329 0 Exp 4,2(0.29);Linear,2(0.29);Poly 2,3(0.43) 2.4032146537889267 20.699802041053772 1.5452189445495605 8.822484970092773 2.622556733610385 1.8335704803466797 37.0757640783863 481.7069787787565 26.612316057925312 304.079998227789 -9.400705419963401 1229.3127339913917 UP 0.7142857142857143 0.2857142857142857 0.0 GO:0051962 6 positive regulation of nervous system development 142 153 4 4 3 4 3 3 35 150 2359 0.8087 0.40211 0.49541 1.96 499271;361921;60628 itgax;ect2;cxcr4 ITGAX_32980;ECT2_8523;CXCR4_8411 59.84530000000055 31.2319 1.65461E-12 78.1828887843747 106.03567576819657 78.25540937144697 37.21883333333388 16.4725 1.65461E-12 50.87048480291171 67.66527915885598 50.80037576892837 136.0598333333339 67.1945 1.65462E-12 180.6225848491354 243.29637949303154 180.65702605579858 148.304;31.2319;1.65461E-12 95.184;16.4725;1.65461E-12 340.985;67.1945;1.65462E-12 0 3 0 3 499271;361921;60628 ITGAX_32980;ECT2_8523;CXCR4_8411 59.84530000000055 31.2319 78.1828887843747 37.21883333333388 16.4725 50.87048480291171 136.0598333333339 67.1945 180.6225848491354 148.304;31.2319;1.65461E-12 95.184;16.4725;1.65461E-12 340.985;67.1945;1.65462E-12 0 Exp 4,1(0.34);Hill,1(0.34);Poly 2,1(0.34) 1.9143853190671387 5.765594005584717 1.744480013847351 2.1538212299346924 0.21005624853765656 1.8672927618026733 -28.62696729593482 148.31756729593593 -20.34653933241109 94.78420599907886 -68.33386271603985 340.4535293827076 DOWN 0.0 1.0 0.0 GO:0071704 3 organic substance metabolic process 1263 1393 43 40 28 25 17 17 21 1376 1133 0.14064 0.91988 0.25107 1.22 362246;360243;89829;25044;25106;114519;291885;24450;60671;266674;266684;29277;24296;25612;25748;26760;54223 tp53inp2;top2a;socs3;sds;rgn;nfil3;mcm5;hmgcs2;gulo;cyp4a8;cyp2d1;cyp2c11;cyp1a1;asns;alas2;akr7a3;adcy4 TP53INP2_32755;TOP2A_10059;SOCS3_32863;SDS_9798;RGN_9699;NFIL3_9304;MCM5_9209;HMGCS2_8812;GULO_8772;CYP4A8_32747;CYP2D1_32660;CYP2C11_32593;CYP1A1_8415;ASNS_8091;ALAS2_8019;AKR7A3_8015;ADCY4_7988 285.93985882352945 126.747 12.3342 306.6046444457097 271.44640548216427 308.54070666705206 175.83614705882354 85.1532 3.46407 182.85537532685808 165.80424777459183 182.76493042393852 759.5987764705883 250.579 36.0856 898.2301746928932 720.701587662286 920.9156830632037 827.265;12.3342;809.124;553.681;752.835;121.321;12.5006;106.351;193.989;76.6586;126.747;216.743;49.0449;157.765;65.3911;62.7952;716.432 495.492;3.46407;488.627;377.484;458.716;82.5516;9.67503;59.8697;112.274;57.8156;85.1532;139.563;39.2363;99.5663;37.2697;48.749;393.708 2498.6;46.5267;2346.74;1035.66;1994.77;229.79;36.0856;208.329;1039.83;112.882;250.579;368.944;64.8529;371.219;133.644;87.647;2087.08 8 9 8 89829;25044;60671;266674;266684;24296;25612;26760 SOCS3_32863;SDS_9798;GULO_8772;CYP4A8_32747;CYP2D1_32660;CYP1A1_8415;ASNS_8091;AKR7A3_8015 253.7255875 142.256 276.9843772766278 163.61317499999998 92.35974999999999 170.76504727688402 663.6762375 310.899 789.4411340305566 809.124;553.681;193.989;76.6586;126.747;49.0449;157.765;62.7952 488.627;377.484;112.274;57.8156;85.1532;39.2363;99.5663;48.749 2346.74;1035.66;1039.83;112.882;250.579;64.8529;371.219;87.647 9 362246;360243;25106;114519;291885;24450;29277;25748;54223 TP53INP2_32755;TOP2A_10059;RGN_9699;NFIL3_9304;MCM5_9209;HMGCS2_8812;CYP2C11_32593;ALAS2_8019;ADCY4_7988 314.5747666666667 121.321 344.85113009161654 186.70101111111114 82.5516 202.66810527590567 844.8632555555555 229.79 1025.1535658476894 827.265;12.3342;752.835;121.321;12.5006;106.351;216.743;65.3911;716.432 495.492;3.46407;458.716;82.5516;9.67503;59.8697;139.563;37.2697;393.708 2498.6;46.5267;1994.77;229.79;36.0856;208.329;368.944;133.644;2087.08 0 Exp 2,3(0.18);Exp 4,1(0.06);Exp 5,2(0.12);Hill,1(0.06);Linear,3(0.18);Poly 2,7(0.42) 2.1588906724163297 44.60507309436798 1.5452189445495605 8.822484970092773 2.276232634960631 1.7148494720458984 140.189262627351 431.69045501970777 88.9122192763641 262.760074841283 332.6072554531428 1186.5902974880337 CONFLICT 0.47058823529411764 0.5294117647058824 0.0 GO:1902679 8 negative regulation of RNA biosynthetic process 225 236 8 8 5 6 4 4 34 232 2277 0.72701 0.47405 0.77545 1.69 24522;25106;114519;24253 zfp354a;rgn;nfil3;cebpb ZFP354A_10203;RGN_9699;NFIL3_9304;CEBPB_32843,CEBPB_8282 24253(-0.009836) 398.5474 371.066 99.2226 337.328042193708 340.1010845077524 322.076911232808 255.4683 246.0503 71.0566 207.33093506401786 219.86701435774614 199.71022687015295 916.9865 754.8199999999999 163.536 881.894528475864 761.7317867137275 821.4932038875099 99.2226;752.835;121.321;620.8109999999999 71.0566;458.716;82.5516;409.549 163.536;1994.77;229.79;1279.85 0 5 0 4 24522;25106;114519;24253 ZFP354A_10203;RGN_9699;NFIL3_9304;CEBPB_32843,CEBPB_8282 398.5474 371.066 337.328042193708 255.4683 246.0503 207.33093506401786 916.9865 754.8199999999999 881.894528475864 99.2226;752.835;121.321;620.8109999999999 71.0566;458.716;82.5516;409.549 163.536;1994.77;229.79;1279.85 0 Exp 2,1(0.2);Linear,2(0.4);Poly 2,2(0.4) 1.7781767779179967 8.945477485656738 1.5669527053833008 2.1583378314971924 0.22745537742282887 1.7148494720458984 67.9659186501662 729.1288813498336 52.28398363726251 458.6526163627375 52.729862093653196 1781.2431379063469 DOWN 0.0 1.0 0.0 GO:0071396 6 cellular response to lipid 195 209 10 9 6 6 4 4 34 205 2304 0.80316 0.38031 0.54806 1.91 363328;24587;24450;24253 ticam1;nefh;hmgcs2;cebpb TICAM1_10015;NEFH_33218;HMGCS2_8812;CEBPB_32843,CEBPB_8282 24253(-0.009836) 384.5710000000007 363.58099999999996 2.95157E-12 392.87670485026115 342.29478135550556 373.380773463634 239.70192500000073 234.70935 2.95157E-12 245.6205110227741 210.91538619803518 233.74036890619283 962.7622500000007 744.0894999999999 2.95158E-12 1088.8720511827432 854.3448952884861 1052.2785939108182 811.122;2.95157E-12;106.351;620.8109999999999 489.389;2.95157E-12;59.8697;409.549 2362.87;2.95158E-12;208.329;1279.85 0 5 0 4 363328;24587;24450;24253 TICAM1_10015;NEFH_33218;HMGCS2_8812;CEBPB_32843,CEBPB_8282 384.5710000000007 363.58099999999996 392.87670485026115 239.70192500000073 234.70935 245.6205110227741 962.7622500000007 744.0894999999999 1088.8720511827432 811.122;2.95157E-12;106.351;620.8109999999999 489.389;2.95157E-12;59.8697;409.549 2362.87;2.95158E-12;208.329;1279.85 0 Exp 4,1(0.2);Hill,1(0.2);Linear,3(0.6) 1.9104431704124645 9.80283784866333 1.5415632724761963 2.578549861907959 0.5073255631855936 1.671766996383667 -0.4481707532552264 769.5901707532566 -1.0061758023178982 480.41002580231935 -104.3323601590879 2029.8568601590891 DOWN 0.0 1.0 0.0 GO:0042221 3 response to chemical 909 981 37 34 28 28 22 22 16 959 1550 0.99536 0.011483 0.017806 2.24 24522;360772;360243;363328;89829;25044;24314;316351;114519;24587;24567;24450;361921;170568;266674;266684;24296;60628;170945;24253;25612;25748 zfp354a;zfand2a;top2a;ticam1;socs3;sds;nqo1;npas2;nfil3;nefh;mt1;hmgcs2;ect2;dmbt1;cyp4a8;cyp2d1;cyp1a1;cxcr4;chrna2;cebpb;asns;alas2 ZFP354A_10203;ZFAND2A_10197;TOP2A_10059;TICAM1_10015;SOCS3_32863;SDS_9798;NQO1_33055;NPAS2_9350;NFIL3_9304;NEFH_33218;MT1A_9255;HMGCS2_8812;ECT2_8523;DMBT1_32993;CYP4A8_32747;CYP2D1_32660;CYP1A1_8415;CXCR4_8411;CHRNA2_32401;CEBPB_32843,CEBPB_8282;ASNS_8091;ALAS2_8019 24253(-0.009836) 252.07668772727294 113.836 1.65461E-12 308.35502865334615 240.59438412517275 310.6352217178321 164.79515181818203 76.8041 1.65461E-12 204.78830201191516 156.82164400846378 207.76886123208885 582.4601172727274 219.0595 1.65462E-12 735.2298698623381 566.8881568014612 741.5548497554081 99.2226;946.037;12.3342;811.122;809.124;553.681;40.5511;155.028;121.321;2.95157E-12;168.588;106.351;31.2319;2.64673;76.6586;126.747;49.0449;1.65461E-12;592.031;620.8109999999999;157.765;65.3911 71.0566;687.617;3.46407;489.389;488.627;377.484;21.5832;98.033;82.5516;2.95157E-12;103.554;59.8697;16.4725;1.09657;57.8156;85.1532;39.2363;1.65461E-12;396.105;409.549;99.5663;37.2697 163.536;1292.08;46.5267;2362.87;2346.74;1035.66;79.3552;382.695;229.79;2.95158E-12;1208.95;208.329;67.1945;8.73928;112.882;250.579;64.8529;1.65462E-12;1168.63;1279.85;371.219;133.644 9 14 9 360772;89829;25044;24314;170568;266674;266684;24296;25612 ZFAND2A_10197;SOCS3_32863;SDS_9798;NQO1_33055;DMBT1_32993;CYP4A8_32747;CYP2D1_32660;CYP1A1_8415;ASNS_8091 306.9172588888889 126.747 363.8911934847507 206.4643522222222 85.1532 248.2271084163926 618.011931111111 250.579 793.3881076737606 946.037;809.124;553.681;40.5511;2.64673;76.6586;126.747;49.0449;157.765 687.617;488.627;377.484;21.5832;1.09657;57.8156;85.1532;39.2363;99.5663 1292.08;2346.74;1035.66;79.3552;8.73928;112.882;250.579;64.8529;371.219 13 24522;360243;363328;316351;114519;24587;24567;24450;361921;60628;170945;24253;25748 ZFP354A_10203;TOP2A_10059;TICAM1_10015;NPAS2_9350;NFIL3_9304;NEFH_33218;MT1A_9255;HMGCS2_8812;ECT2_8523;CXCR4_8411;CHRNA2_32401;CEBPB_32843,CEBPB_8282;ALAS2_8019 214.1101384615388 106.351 272.5800391042615 135.9472438461542 71.0566 173.5233219074986 557.8473230769234 208.329 724.3879041765756 99.2226;12.3342;811.122;155.028;121.321;2.95157E-12;168.588;106.351;31.2319;1.65461E-12;592.031;620.8109999999999;65.3911 71.0566;3.46407;489.389;98.033;82.5516;2.95157E-12;103.554;59.8697;16.4725;1.65461E-12;396.105;409.549;37.2697 163.536;46.5267;2362.87;382.695;229.79;2.95158E-12;1208.95;208.329;67.1945;1.65462E-12;1168.63;1279.85;133.644 0 Exp 4,4(0.18);Exp 5,1(0.05);Hill,3(0.14);Linear,6(0.27);Poly 2,9(0.4) 2.026544836785095 51.38789916038513 1.5415632724761963 8.822484970092773 1.493063394256671 1.744480013847351 123.22332224580646 380.9300532087393 79.21956694541079 250.37073669095327 275.22710878897 889.6931257564853 CONFLICT 0.4090909090909091 0.5909090909090909 0.0 GO:0030856 6 regulation of epithelial cell differentiation 50 51 3 3 3 2 2 2 36 49 2460 0.96099 0.17564 0.17564 3.92 170568;24253 dmbt1;cebpb DMBT1_32993;CEBPB_32843,CEBPB_8282 24253(-0.009836) 311.728865 311.728865 2.64673 437.1081472042318 216.21266752104856 415.71245397587063 205.32278499999998 205.32278499999998 1.09657 288.81948304512355 142.21039747129734 274.68226529447827 644.29464 644.29464 8.73928 898.8110097509148 447.88784581706847 854.8157542108278 2.64673;620.8109999999999 1.09657;409.549 8.73928;1279.85 1 2 1 170568 DMBT1_32993 2.64673 2.64673 1.09657 1.09657 8.73928 8.73928 2.64673 1.09657 8.73928 1 24253 CEBPB_32843,CEBPB_8282 620.8109999999999 620.8109999999999 409.549 409.549 1279.85 1279.85 620.8109999999999 409.549 1279.85 0 Exp 4,1(0.34);Linear,2(0.67) 1.62865423837958 4.887850284576416 1.5669527053833008 1.671766996383667 0.0551537946045411 1.6491305828094482 -294.07211959999984 917.5298495999997 -194.9605964 605.6061664 -601.3938655999997 1889.9831455999997 CONFLICT 0.5 0.5 0.0 GO:0014070 5 response to organic cyclic compound 433 471 21 20 17 17 14 14 24 457 2052 0.99809 0.0056201 0.0094952 2.97 24522;363328;89829;25044;24314;24587;24450;266674;266684;24296;60628;24253;25612;25748 zfp354a;ticam1;socs3;sds;nqo1;nefh;hmgcs2;cyp4a8;cyp2d1;cyp1a1;cxcr4;cebpb;asns;alas2 ZFP354A_10203;TICAM1_10015;SOCS3_32863;SDS_9798;NQO1_33055;NEFH_33218;HMGCS2_8812;CYP4A8_32747;CYP2D1_32660;CYP1A1_8415;CXCR4_8411;CEBPB_32843,CEBPB_8282;ASNS_8091;ALAS2_8019 24253(-0.009836) 251.17637857142887 102.7868 1.65461E-12 303.5213916218124 240.00799904269536 300.73831091904765 159.7571142857146 65.46315 1.65461E-12 188.86395735624006 150.5754776879813 185.6649258936425 600.6797928571432 185.9325 1.65462E-12 834.8822358571502 588.3595849799733 849.4615242799405 99.2226;811.122;809.124;553.681;40.5511;2.95157E-12;106.351;76.6586;126.747;49.0449;1.65461E-12;620.8109999999999;157.765;65.3911 71.0566;489.389;488.627;377.484;21.5832;2.95157E-12;59.8697;57.8156;85.1532;39.2363;1.65461E-12;409.549;99.5663;37.2697 163.536;2362.87;2346.74;1035.66;79.3552;2.95158E-12;208.329;112.882;250.579;64.8529;1.65462E-12;1279.85;371.219;133.644 7 8 7 89829;25044;24314;266674;266684;24296;25612 SOCS3_32863;SDS_9798;NQO1_33055;CYP4A8_32747;CYP2D1_32660;CYP1A1_8415;ASNS_8091 259.0816571428571 126.747 300.62770269802627 167.06651428571428 85.1532 186.3618590024832 608.7554428571428 250.579 837.6093771635715 809.124;553.681;40.5511;76.6586;126.747;49.0449;157.765 488.627;377.484;21.5832;57.8156;85.1532;39.2363;99.5663 2346.74;1035.66;79.3552;112.882;250.579;64.8529;371.219 7 24522;363328;24587;24450;60628;24253;25748 ZFP354A_10203;TICAM1_10015;NEFH_33218;HMGCS2_8812;CXCR4_8411;CEBPB_32843,CEBPB_8282;ALAS2_8019 243.27110000000064 99.2226 330.27540413254553 152.44771428571494 59.8697 205.9823170020375 592.6041428571435 163.536 899.1587441188988 99.2226;811.122;2.95157E-12;106.351;1.65461E-12;620.8109999999999;65.3911 71.0566;489.389;2.95157E-12;59.8697;1.65461E-12;409.549;37.2697 163.536;2362.87;2.95158E-12;208.329;1.65462E-12;1279.85;133.644 0 Exp 4,2(0.14);Exp 5,1(0.07);Hill,2(0.14);Linear,5(0.34);Poly 2,5(0.34) 2.003592414320566 34.52186441421509 1.5415632724761963 8.822484970092773 1.8426690025802834 1.7132161855697632 92.18215059063647 410.17060655222144 60.82412332648782 258.69010524494144 163.34173297376822 1038.0178527405183 CONFLICT 0.5 0.5 0.0 GO:0048584 5 positive regulation of response to stimulus 502 537 6 6 6 5 5 5 33 532 1977 0.15655 0.9275 0.31538 0.93 363328;25106;316351;60628;24253 ticam1;rgn;npas2;cxcr4;cebpb TICAM1_10015;RGN_9699;NPAS2_9350;CXCR4_8411;CEBPB_32843,CEBPB_8282 24253(-0.009836) 467.95920000000035 620.8109999999999 1.65461E-12 367.14790966679845 452.8513665306124 355.5842405712917 291.13740000000035 409.549 1.65461E-12 225.53153109554268 281.76765591836755 217.91701997327206 1204.0370000000003 1279.85 1.65462E-12 1012.2015595324871 1171.6202895408164 994.0182938921762 811.122;752.835;155.028;1.65461E-12;620.8109999999999 489.389;458.716;98.033;1.65461E-12;409.549 2362.87;1994.77;382.695;1.65462E-12;1279.85 0 6 0 5 363328;25106;316351;60628;24253 TICAM1_10015;RGN_9699;NPAS2_9350;CXCR4_8411;CEBPB_32843,CEBPB_8282 467.95920000000035 620.8109999999999 367.14790966679845 291.13740000000035 409.549 225.53153109554268 1204.0370000000003 1279.85 1012.2015595324871 811.122;752.835;155.028;1.65461E-12;620.8109999999999 489.389;458.716;98.033;1.65461E-12;409.549 2362.87;1994.77;382.695;1.65462E-12;1279.85 0 Exp 2,1(0.17);Hill,1(0.17);Linear,3(0.5);Poly 2,1(0.17) 1.6318576164090521 9.802790999412537 1.5415632724761963 1.744480013847351 0.08743470775579981 1.6193598508834839 146.13986794573026 789.7785320542705 93.45029683709782 488.8245031629029 316.8032143339914 2091.270785666009 DOWN 0.0 1.0 0.0 GO:0055114 3 oxidation-reduction process 260 296 11 11 9 8 7 7 31 289 2220 0.93416 0.14418 0.19778 2.36 24314;60671;266674;266684;29277;24296;26760 nqo1;gulo;cyp4a8;cyp2d1;cyp2c11;cyp1a1;akr7a3 NQO1_33055;GULO_8772;CYP4A8_32747;CYP2D1_32660;CYP2C11_32593;CYP1A1_8415;AKR7A3_8015 109.5041142857143 76.6586 40.5511 71.42079165612836 87.40502672583288 63.979406644591194 72.05347142857143 57.8156 21.5832 42.2627903030043 58.78728679137084 38.750367717662535 286.2985857142857 112.882 64.8529 350.55082060034425 202.03737968596397 283.0683762086137 40.5511;193.989;76.6586;126.747;216.743;49.0449;62.7952 21.5832;112.274;57.8156;85.1532;139.563;39.2363;48.749 79.3552;1039.83;112.882;250.579;368.944;64.8529;87.647 6 1 6 24314;60671;266674;266684;24296;26760 NQO1_33055;GULO_8772;CYP4A8_32747;CYP2D1_32660;CYP1A1_8415;AKR7A3_8015 91.63096666666667 69.7269 58.632246828197424 60.80188333333333 53.282300000000006 32.862546490642934 272.52434999999997 100.2645 381.9284291649196 40.5511;193.989;76.6586;126.747;49.0449;62.7952 21.5832;112.274;57.8156;85.1532;39.2363;48.749 79.3552;1039.83;112.882;250.579;64.8529;87.647 1 29277 CYP2C11_32593 216.743 216.743 139.563 139.563 368.944 368.944 216.743 139.563 368.944 0 Exp 2,1(0.15);Exp 4,1(0.15);Poly 2,5(0.72) 2.7977893338966977 26.286919593811035 1.5671749114990234 8.822484970092773 3.323099966178886 1.8055906295776367 56.59485140050195 162.4133771709266 40.74475822961342 103.36218462752944 26.60690361880961 545.9902678097618 UP 0.8571428571428571 0.14285714285714285 0.0 GO:0006955 3 immune response 185 212 4 4 4 3 3 3 35 209 2300 0.60916 0.62481 1.0 1.42 114519;170568;60628 nfil3;dmbt1;cxcr4 NFIL3_9304;DMBT1_32993;CXCR4_8411 41.32257666666722 2.64673 1.65461E-12 69.29330484821433 52.259117202618704 72.19921486894536 27.88272333333388 1.09657 1.65461E-12 47.34781065094337 35.258756319825686 49.43771411495657 79.50976000000055 8.73928 1.65462E-12 130.21983971182217 100.57143481795536 135.12094991687843 121.321;2.64673;1.65461E-12 82.5516;1.09657;1.65461E-12 229.79;8.73928;1.65462E-12 1 2 1 170568 DMBT1_32993 2.64673 2.64673 1.09657 1.09657 8.73928 8.73928 2.64673 1.09657 8.73928 2 114519;60628 NFIL3_9304;CXCR4_8411 60.66050000000082 60.66050000000082 85.78690180033196 41.27580000000082 41.27580000000082 58.37279615779822 114.89500000000082 114.89500000000082 162.48606724885556 121.321;1.65461E-12 82.5516;1.65461E-12 229.79;1.65462E-12 0 Exp 4,1(0.34);Hill,1(0.34);Poly 2,1(0.34) 1.8380055664846384 5.551948428153992 1.6491305828094482 2.1583378314971924 0.27069719532634096 1.744480013847351 -37.090179419357256 119.73533275269169 -25.69636826739483 81.4618149340626 -67.84786064244238 226.86738064244346 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0010508 8 positive regulation of autophagy 35 37 2 2 2 2 2 2 36 35 2474 0.98321 0.1042 0.1042 5.41 362246;363328 tp53inp2;ticam1 TP53INP2_32755;TICAM1_10015 819.1935 819.1935 811.122 11.414824768690705 820.291072392878 11.308797203285788 492.44050000000004 492.44050000000004 489.389 4.315472685576114 492.85544668362354 4.2753880525028185 2430.7349999999997 2430.7349999999997 2362.87 95.9756034104588 2439.9633652905495 95.08412589981045 0.5 819.1935 827.265;811.122 495.492;489.389 2498.6;2362.87 0 2 0 2 362246;363328 TP53INP2_32755;TICAM1_10015 819.1935 819.1935 11.414824768690705 492.44050000000004 492.44050000000004 4.315472685576114 2430.7349999999997 2430.7349999999997 95.9756034104588 827.265;811.122 495.492;489.389 2498.6;2362.87 0 Linear,2(1) 1.5576627592161203 3.115493655204773 1.5415632724761963 1.5739303827285767 0.022887003146870786 1.5577468276023865 803.3733599999999 835.01364 486.45956 498.4214400000001 2297.7195999999994 2563.7504 DOWN 0.0 1.0 0.0 GO:0000281 5 mitotic cytokinesis 13 16 7 7 4 6 3 3 35 13 2496 0.99993 0.0015013 0.0015013 18.75 315740;361308;361921 kif23;kif20a;ect2 KIF23_32798;KIF20A_8961;ECT2_8523 25.614900000000002 31.2319 10.3381 13.383628866641516 17.765576521349324 13.26820517050667 12.084926666666666 15.546 4.23628 6.812895231554159 8.01941963913482 6.727919718477971 61.81503333333334 67.1945 21.7065 37.70769934182318 41.41171528633867 36.453506191872506 0.0 10.3381 0.5 20.785 10.3381;35.2747;31.2319 4.23628;15.546;16.4725 21.7065;96.5441;67.1945 0 3 0 3 315740;361308;361921 KIF23_32798;KIF20A_8961;ECT2_8523 25.614900000000002 31.2319 13.383628866641516 12.084926666666666 15.546 6.812895231554159 61.81503333333334 67.1945 37.70769934182318 10.3381;35.2747;31.2319 4.23628;15.546;16.4725 21.7065;96.5441;67.1945 0 Exp 4,2(0.67);Exp 5,1(0.34) 1.8282029236311317 5.527412414550781 1.595955729484558 2.1538212299346924 0.28452802336146465 1.7776354551315308 10.469898211376533 40.75990178862347 4.375409950705589 19.794443382627744 19.14475461690806 104.48531204975862 DOWN 0.0 1.0 0.0 GO:0051173 6 positive regulation of nitrogen compound metabolic process 649 698 23 22 16 17 11 11 27 687 1822 0.66276 0.47662 0.85499 1.58 360772;362246;360243;363328;25106;363140;316351;114519;361921;60628;24253 zfand2a;tp53inp2;top2a;ticam1;rgn;rassf1;npas2;nfil3;ect2;cxcr4;cebpb ZFAND2A_10197;TP53INP2_32755;TOP2A_10059;TICAM1_10015;RGN_9699;RASSF1_32475;NPAS2_9350;NFIL3_9304;ECT2_8523;CXCR4_8411;CEBPB_32843,CEBPB_8282 24253(-0.009836) 471.0757363636365 620.8109999999999 1.65461E-12 400.65253189319594 529.9821255579683 402.221066475471 304.5271063636365 409.549 1.65461E-12 265.11796044468 347.861070271242 271.01941776042014 1029.6451090909093 1171.72 1.65462E-12 950.2503691893523 1058.8617051507495 891.5564796997755 946.037;827.265;12.3342;811.122;752.835;903.848;155.028;121.321;31.2319;1.65461E-12;620.8109999999999 687.617;495.492;3.46407;489.389;458.716;608.514;98.033;82.5516;16.4725;1.65461E-12;409.549 1292.08;2498.6;46.5267;2362.87;1994.77;1171.72;382.695;229.79;67.1945;1.65462E-12;1279.85 2 10 2 360772;363140 ZFAND2A_10197;RASSF1_32475 924.9425 924.9425 29.832127991479105 648.0654999999999 648.0654999999999 55.93426771220036 1231.9 1231.9 85.10737218360741 946.037;903.848 687.617;608.514 1292.08;1171.72 9 362246;360243;363328;25106;316351;114519;361921;60628;24253 TP53INP2_32755;TOP2A_10059;TICAM1_10015;RGN_9699;NPAS2_9350;NFIL3_9304;ECT2_8523;CXCR4_8411;CEBPB_32843,CEBPB_8282 370.21645555555574 155.028 370.9432450305203 228.18524111111134 98.033 226.73131342029893 984.6995777777779 382.695 1056.0847141556953 827.265;12.3342;811.122;752.835;155.028;121.321;31.2319;1.65461E-12;620.8109999999999 495.492;3.46407;489.389;458.716;98.033;82.5516;16.4725;1.65461E-12;409.549 2498.6;46.5267;2362.87;1994.77;382.695;229.79;67.1945;1.65462E-12;1279.85 0 Exp 2,1(0.09);Exp 4,1(0.09);Hill,2(0.17);Linear,4(0.34);Poly 2,4(0.34) 1.9296796517656747 23.743235111236572 1.5415632724761963 2.846071243286133 0.47848652282788967 1.7296647429466248 234.305220508415 707.8462522188581 147.85240382187243 461.2018089054006 468.08302675130517 1591.207191430513 DOWN 0.18181818181818182 0.8181818181818182 0.0 GO:0043200 5 response to amino acid 78 82 5 5 4 5 4 4 34 78 2431 0.99334 0.032073 0.032073 4.88 25044;24450;24253;25612 sds;hmgcs2;cebpb;asns SDS_9798;HMGCS2_8812;CEBPB_32843,CEBPB_8282;ASNS_8091 24253(-0.009836) 359.652 355.723 106.351 265.0603915412485 278.91033070525447 254.9752861214319 236.61724999999998 238.52515 59.8697 182.36546707141858 180.4118731166771 175.8089973415038 723.7645 703.4395000000001 208.329 515.2578546905746 563.8018708235181 501.2384165185621 553.681;106.351;620.8109999999999;157.765 377.484;59.8697;409.549;99.5663 1035.66;208.329;1279.85;371.219 2 3 2 25044;25612 SDS_9798;ASNS_8091 355.723 355.723 279.95488838025324 238.52515 238.52515 196.5174902817685 703.4395000000001 703.4395000000001 469.83073679837076 553.681;157.765 377.484;99.5663 1035.66;371.219 2 24450;24253 HMGCS2_8812;CEBPB_32843,CEBPB_8282 363.58099999999996 363.58099999999996 363.77815464923117 234.70935 234.70935 247.26060427056504 744.0894999999999 744.0894999999999 757.6797652837905 106.351;620.8109999999999 59.8697;409.549 208.329;1279.85 0 Exp 4,1(0.2);Linear,3(0.6);Poly 2,1(0.2) 1.7560255705818721 8.96225643157959 1.5452189445495605 2.578549861907959 0.4420452430362977 1.5997679233551025 99.89281628957644 619.4111837104235 57.89909227000979 415.33540772999027 218.81180240323675 1228.7171975967633 CONFLICT 0.5 0.5 0.0 GO:0065007 2 biological regulation 1742 1890 63 59 42 42 29 29 9 1861 648 0.67816 0.46685 0.85365 1.53 24522;360772;362246;360243;363328;89829;299276;25106;363140;338475;24314;316351;114519;24587;24567;304477;315740;361308;499271;83928;361921;170568;24296;60628;170945;24253;25612;25748;54223 zfp354a;zfand2a;tp53inp2;top2a;ticam1;socs3;serpina3m;rgn;rassf1;nrep;nqo1;npas2;nfil3;nefh;mt1;kntc1;kif23;kif20a;itgax;fetub;ect2;dmbt1;cyp1a1;cxcr4;chrna2;cebpb;asns;alas2;adcy4 ZFP354A_10203;ZFAND2A_10197;TP53INP2_32755;TOP2A_10059;TICAM1_10015;SOCS3_32863;SERPINA3M_9809;RGN_9699;RASSF1_32475;NREP_9364;NQO1_33055;NPAS2_9350;NFIL3_9304;NEFH_33218;MT1A_9255;KNTC1_8976;KIF23_32798;KIF20A_8961;ITGAX_32980;FETUB_33027;ECT2_8523;DMBT1_32993;CYP1A1_8415;CXCR4_8411;CHRNA2_32401;CEBPB_32843,CEBPB_8282;ASNS_8091;ALAS2_8019;ADCY4_7988 24253(-0.009836) 317.80147000000017 148.304 1.65461E-12 341.2049276907425 328.28084304483923 347.1114591533531 202.88181000000017 95.184 1.65461E-12 220.26437528740857 211.2101186428514 226.40977583010934 743.3776372413794 340.985 1.65462E-12 834.8763821882288 737.8422888720671 812.1696987687789 99.2226;946.037;827.265;12.3342;811.122;809.124;466.86;752.835;903.848;114.178;40.5511;155.028;121.321;2.95157E-12;168.588;12.7573;10.3381;35.2747;148.304;545.901;31.2319;2.64673;49.0449;1.65461E-12;592.031;620.8109999999999;157.765;65.3911;716.432 71.0566;687.617;495.492;3.46407;489.389;488.627;296.126;458.716;608.514;79.0815;21.5832;98.033;82.5516;2.95157E-12;103.554;9.63387;4.23628;15.546;95.184;382.164;16.4725;1.09657;39.2363;1.65461E-12;396.105;409.549;99.5663;37.2697;393.708 163.536;1292.08;2498.6;46.5267;2362.87;2346.74;918.743;1994.77;1171.72;204.229;79.3552;382.695;229.79;2.95158E-12;1208.95;40.2833;21.7065;96.5441;340.985;976.618;67.1945;8.73928;64.8529;1.65462E-12;1168.63;1279.85;371.219;133.644;2087.08 8 22 8 360772;89829;363140;24314;83928;170568;24296;25612 ZFAND2A_10197;SOCS3_32863;RASSF1_32475;NQO1_33055;FETUB_33027;DMBT1_32993;CYP1A1_8415;ASNS_8091 431.86471625 351.83299999999997 414.2991139689792 291.05054625 240.86515 283.38482252230745 788.9155475 673.9185 817.0199306021129 946.037;809.124;903.848;40.5511;545.901;2.64673;49.0449;157.765 687.617;488.627;608.514;21.5832;382.164;1.09657;39.2363;99.5663 1292.08;2346.74;1171.72;79.3552;976.618;8.73928;64.8529;371.219 21 24522;362246;360243;363328;299276;25106;338475;316351;114519;24587;24567;304477;315740;361308;499271;361921;60628;170945;24253;25748;54223 ZFP354A_10203;TP53INP2_32755;TOP2A_10059;TICAM1_10015;SERPINA3M_9809;RGN_9699;NREP_9364;NPAS2_9350;NFIL3_9304;NEFH_33218;MT1A_9255;KNTC1_8976;KIF23_32798;KIF20A_8961;ITGAX_32980;ECT2_8523;CXCR4_8411;CHRNA2_32401;CEBPB_32843,CEBPB_8282;ALAS2_8019;ADCY4_7988 274.348804761905 121.321 309.3979617419293 169.29372000000023 82.5516 188.4713762255269 726.0298619047622 229.79 860.8414380225512 99.2226;827.265;12.3342;811.122;466.86;752.835;114.178;155.028;121.321;2.95157E-12;168.588;12.7573;10.3381;35.2747;148.304;31.2319;1.65461E-12;592.031;620.8109999999999;65.3911;716.432 71.0566;495.492;3.46407;489.389;296.126;458.716;79.0815;98.033;82.5516;2.95157E-12;103.554;9.63387;4.23628;15.546;95.184;16.4725;1.65461E-12;396.105;409.549;37.2697;393.708 163.536;2498.6;46.5267;2362.87;918.743;1994.77;204.229;382.695;229.79;2.95158E-12;1208.95;40.2833;21.7065;96.5441;340.985;67.1945;1.65462E-12;1168.63;1279.85;133.644;2087.08 0 Exp 2,4(0.14);Exp 4,4(0.14);Exp 5,3(0.1);Hill,3(0.1);Linear,6(0.2);Poly 2,10(0.34) 1.9534501245769278 63.5514612197876 1.5054508447647095 8.822484970092773 1.3204406014004841 1.7424405813217163 193.61554770699055 441.98739229300963 122.71375739158945 283.0498626084109 439.513639073485 1047.2416354092738 DOWN 0.27586206896551724 0.7241379310344828 0.0 GO:0060341 5 regulation of cellular localization 248 267 5 5 4 4 3 3 35 264 2245 0.42459 0.77768 0.79196 1.12 362246;24587;361921 tp53inp2;nefh;ect2 TP53INP2_32755;NEFH_33218;ECT2_8523 286.1656333333343 31.2319 2.95157E-12 468.8659204396311 491.82330078164733 492.33555065884656 170.65483333333432 16.4725 2.95157E-12 281.4377807794874 294.274662673841 295.3129468295662 855.2648333333342 67.1945 2.95158E-12 1423.5665167845445 1481.769589889352 1492.2221947130586 827.265;2.95157E-12;31.2319 495.492;2.95157E-12;16.4725 2498.6;2.95158E-12;67.1945 0 3 0 3 362246;24587;361921 TP53INP2_32755;NEFH_33218;ECT2_8523 286.1656333333343 31.2319 468.8659204396311 170.65483333333432 16.4725 281.4377807794874 855.2648333333342 67.1945 1423.5665167845445 827.265;2.95157E-12;31.2319 495.492;2.95157E-12;16.4725 2498.6;2.95158E-12;67.1945 0 Exp 4,1(0.34);Hill,1(0.34);Linear,1(0.34) 2.023480801511112 6.171756625175476 1.5739303827285767 2.444005012512207 0.44300298790142534 2.1538212299346924 -244.40610281080455 816.7373694774732 -147.8219965132749 489.13166317994353 -755.6523295494594 2466.181996216128 DOWN 0.0 1.0 0.0 GO:1990830 7 cellular response to leukemia inhibitory factor 26 32 2 2 2 2 2 2 36 30 2479 0.98872 0.081247 0.081247 6.25 89829;24587 socs3;nefh SOCS3_32863;NEFH_33218 404.5620000000015 404.5620000000015 2.95157E-12 572.137067220782 571.094590538337 521.415972391698 244.31350000000148 244.31350000000148 2.95157E-12 345.5114651708371 344.8819173463848 314.8811830347853 1173.3700000000013 1173.3700000000013 2.95158E-12 1659.3957676817165 1656.3722240348025 1512.287015402455 0.5 404.5620000000015 809.124;2.95157E-12 488.627;2.95157E-12 2346.74;2.95158E-12 1 1 1 89829 SOCS3_32863 809.124 809.124 488.627 488.627 2346.74 2346.74 809.124 488.627 2346.74 1 24587 NEFH_33218 2.95157E-12 2.95157E-12 2.95157E-12 2.95157E-12 2.95158E-12 2.95158E-12 2.95157E-12 2.95157E-12 2.95158E-12 0 Hill,1(0.5);Linear,1(0.5) 2.0624134239864778 4.184406161308289 1.7404011487960815 2.444005012512207 0.4975230633027278 2.0922030806541443 -388.37951999999564 1197.5035199999986 -234.54095999999558 723.1679599999985 -1126.4351999999958 3473.1751999999983 CONFLICT 0.5 0.5 0.0 GO:0050790 4 regulation of catalytic activity 528 565 19 16 11 12 6 6 32 559 1950 0.22875 0.87869 0.43293 1.06 89829;299276;25106;24314;83928;361921 socs3;serpina3m;rgn;nqo1;fetub;ect2 SOCS3_32863;SERPINA3M_9809;RGN_9699;NQO1_33055;FETUB_33027;ECT2_8523 441.0838333333333 506.3805 31.2319 338.43713777381276 458.8467281802852 311.3632529930358 277.28145 339.145 16.4725 210.8761756343637 290.52537658132763 194.4303141693988 1063.90345 947.6805 67.1945 949.0665352375328 1077.1535126843476 896.521633840594 809.124;466.86;752.835;40.5511;545.901;31.2319 488.627;296.126;458.716;21.5832;382.164;16.4725 2346.74;918.743;1994.77;79.3552;976.618;67.1945 3 3 3 89829;24314;83928 SOCS3_32863;NQO1_33055;FETUB_33027 465.1920333333333 545.901 390.5912551874444 297.45806666666664 382.164 244.77295425764126 1134.2377333333334 976.618 1141.8806606076719 809.124;40.5511;545.901 488.627;21.5832;382.164 2346.74;79.3552;976.618 3 299276;25106;361921 SERPINA3M_9809;RGN_9699;ECT2_8523 416.9756333333333 466.86 363.37872256187956 257.1048333333333 296.126 223.68910771220695 993.5691666666667 918.743 965.9637899339618 466.86;752.835;31.2319 296.126;458.716;16.4725 918.743;1994.77;67.1945 0 Exp 2,3(0.5);Exp 4,2(0.34);Linear,1(0.17) 1.8486909172511008 11.293325066566467 1.5054508447647095 2.5798087120056152 0.4076014906650318 1.72762531042099 170.2777227990751 711.8899438675915 108.54536712351887 446.01753287648114 304.4920605275187 1823.3148394724813 CONFLICT 0.5 0.5 0.0 GO:0010604 6 positive regulation of macromolecule metabolic process 704 754 25 24 17 18 12 12 26 742 1767 0.67942 0.45491 0.85802 1.59 360772;362246;360243;363328;25106;363140;316351;114519;499271;361921;60628;24253 zfand2a;tp53inp2;top2a;ticam1;rgn;rassf1;npas2;nfil3;itgax;ect2;cxcr4;cebpb ZFAND2A_10197;TP53INP2_32755;TOP2A_10059;TICAM1_10015;RGN_9699;RASSF1_32475;NPAS2_9350;NFIL3_9304;ITGAX_32980;ECT2_8523;CXCR4_8411;CEBPB_32843,CEBPB_8282 24253(-0.009836) 444.17809166666683 387.91949999999997 1.65461E-12 393.206435191554 479.87934730966674 396.8706535278739 287.08184750000015 253.791 1.65461E-12 259.90344728267746 314.6922236109222 266.8800124965615 972.2567666666669 777.2075 1.65462E-12 927.5818672589538 964.626235629909 865.4103779171918 946.037;827.265;12.3342;811.122;752.835;903.848;155.028;121.321;148.304;31.2319;1.65461E-12;620.8109999999999 687.617;495.492;3.46407;489.389;458.716;608.514;98.033;82.5516;95.184;16.4725;1.65461E-12;409.549 1292.08;2498.6;46.5267;2362.87;1994.77;1171.72;382.695;229.79;340.985;67.1945;1.65462E-12;1279.85 2 11 2 360772;363140 ZFAND2A_10197;RASSF1_32475 924.9425 924.9425 29.832127991479105 648.0654999999999 648.0654999999999 55.93426771220036 1231.9 1231.9 85.10737218360741 946.037;903.848 687.617;608.514 1292.08;1171.72 10 362246;360243;363328;25106;316351;114519;499271;361921;60628;24253 TP53INP2_32755;TOP2A_10059;TICAM1_10015;RGN_9699;NPAS2_9350;NFIL3_9304;ITGAX_32980;ECT2_8523;CXCR4_8411;CEBPB_32843,CEBPB_8282 348.02521000000013 151.666 356.69964838281396 214.88511700000018 96.60849999999999 217.86262363795962 920.3281200000001 361.84000000000003 1016.281402393921 827.265;12.3342;811.122;752.835;155.028;121.321;148.304;31.2319;1.65461E-12;620.8109999999999 495.492;3.46407;489.389;458.716;98.033;82.5516;95.184;16.4725;1.65461E-12;409.549 2498.6;46.5267;2362.87;1994.77;382.695;229.79;340.985;67.1945;1.65462E-12;1279.85 0 Exp 2,1(0.08);Exp 4,1(0.08);Hill,2(0.16);Linear,4(0.31);Poly 2,5(0.39) 1.924807531466052 25.610527873039246 1.5415632724761963 2.846071243286133 0.4591549989896916 1.744480013847351 221.70060728582862 666.655576047505 140.02762875307388 434.1360662469264 447.42791872444127 1497.0856146088918 DOWN 0.16666666666666666 0.8333333333333334 0.0 GO:0007584 4 response to nutrient 144 154 7 7 5 6 5 5 33 149 2360 0.97557 0.07572 0.07572 3.25 24522;25044;24314;24450;24296 zfp354a;sds;nqo1;hmgcs2;cyp1a1 ZFP354A_10203;SDS_9798;NQO1_33055;HMGCS2_8812;CYP1A1_8415 169.77012 99.2226 40.5511 216.59791955135907 118.82485796705825 166.7683037052869 113.84595999999999 59.8697 21.5832 148.60047136194757 78.14350450572033 114.18482275390357 310.34662000000003 163.536 64.8529 409.77574806695435 215.63713738306296 316.24159604776065 99.2226;553.681;40.5511;106.351;49.0449 71.0566;377.484;21.5832;59.8697;39.2363 163.536;1035.66;79.3552;208.329;64.8529 3 2 3 25044;24314;24296 SDS_9798;NQO1_33055;CYP1A1_8415 214.42566666666667 49.0449 293.8344296639578 146.10116666666667 39.2363 200.57771475396595 393.2893666666667 79.3552 556.3565422488742 553.681;40.5511;49.0449 377.484;21.5832;39.2363 1035.66;79.3552;64.8529 2 24522;24450 ZFP354A_10203;HMGCS2_8812 102.7868 102.7868 5.040539979010178 65.46315 65.46315 7.910332850455866 185.9325 185.9325 31.673434049689142 99.2226;106.351 71.0566;59.8697 163.536;208.329 0 Exp 4,2(0.4);Linear,1(0.2);Poly 2,2(0.4) 2.780790811185987 17.359632968902588 1.5452189445495605 8.822484970092773 3.02567696385413 2.578549861907959 -20.086327385532883 359.6265673855329 -16.40809613789959 244.10001613789962 -48.83765985774687 669.5308998577468 UP 0.6 0.4 0.0 GO:0044260 4 cellular macromolecule metabolic process 676 733 27 24 15 12 6 6 32 727 1782 0.049102 0.98048 0.10225 0.82 362246;360243;89829;114519;291885;25748 tp53inp2;top2a;socs3;nfil3;mcm5;alas2 TP53INP2_32755;TOP2A_10059;SOCS3_32863;NFIL3_9304;MCM5_9209;ALAS2_8019 307.98931666666664 93.35605 12.3342 397.29276132504816 342.42147149670063 399.9044555955148 186.1799 59.91065 3.46407 238.5792695923331 206.83091358338334 240.31638646190254 881.8977166666667 181.71699999999998 36.0856 1196.4831932630702 976.0960974145171 1210.6065772121115 827.265;12.3342;809.124;121.321;12.5006;65.3911 495.492;3.46407;488.627;82.5516;9.67503;37.2697 2498.6;46.5267;2346.74;229.79;36.0856;133.644 1 5 1 89829 SOCS3_32863 809.124 809.124 488.627 488.627 2346.74 2346.74 809.124 488.627 2346.74 5 362246;360243;114519;291885;25748 TP53INP2_32755;TOP2A_10059;NFIL3_9304;MCM5_9209;ALAS2_8019 207.76237999999998 65.3911 349.2293394028085 125.69048000000001 37.2697 209.06412977718333 588.92926 133.644 1070.3906600811117 827.265;12.3342;121.321;12.5006;65.3911 495.492;3.46407;82.5516;9.67503;37.2697 2498.6;46.5267;229.79;36.0856;133.644 0 Exp 5,2(0.34);Hill,1(0.17);Linear,2(0.34);Poly 2,1(0.17) 1.9270736812456715 11.808507800102234 1.5739303827285767 2.846071243286133 0.47241870502374395 1.7584760785102844 -9.911100957585461 625.8897342909188 -4.723274744326716 377.0830747443268 -75.48823104138239 1839.2836643747155 DOWN 0.16666666666666666 0.8333333333333334 0.0 GO:0006355 7 regulation of transcription, DNA-templated 466 499 15 15 9 12 7 7 31 492 2017 0.52546 0.63781 1.0 1.4 24522;362246;360243;363328;316351;114519;24253 zfp354a;tp53inp2;top2a;ticam1;npas2;nfil3;cebpb ZFP354A_10203;TP53INP2_32755;TOP2A_10059;TICAM1_10015;NPAS2_9350;NFIL3_9304;CEBPB_32843,CEBPB_8282 24253(-0.009836) 378.1576857142857 155.028 12.3342 359.49493567177194 355.584661218929 360.4045360787455 235.64789571428574 98.033 3.46407 218.1440882536467 220.1948902313296 218.10369301900712 994.838242857143 382.695 46.5267 1061.7923822069513 953.8080268475783 1072.7698152768808 99.2226;827.265;12.3342;811.122;155.028;121.321;620.8109999999999 71.0566;495.492;3.46407;489.389;98.033;82.5516;409.549 163.536;2498.6;46.5267;2362.87;382.695;229.79;1279.85 0 8 0 7 24522;362246;360243;363328;316351;114519;24253 ZFP354A_10203;TP53INP2_32755;TOP2A_10059;TICAM1_10015;NPAS2_9350;NFIL3_9304;CEBPB_32843,CEBPB_8282 378.1576857142857 155.028 359.49493567177194 235.64789571428574 98.033 218.1440882536467 994.838242857143 382.695 1061.7923822069513 99.2226;827.265;12.3342;811.122;155.028;121.321;620.8109999999999 71.0566;495.492;3.46407;489.389;98.033;82.5516;409.549 163.536;2498.6;46.5267;2362.87;382.695;229.79;1279.85 0 Hill,1(0.13);Linear,4(0.5);Poly 2,3(0.38) 1.8034588466091845 14.755371451377869 1.5415632724761963 2.846071243286133 0.45556057760846247 1.6228486895561218 111.84011044937785 644.4752609791935 74.0444936148246 397.2512978137469 208.25143841246063 1781.425047301825 DOWN 0.0 1.0 0.0 GO:0009617 5 response to bacterium 110 127 4 4 4 4 4 4 34 123 2386 0.96189 0.11802 0.11802 3.15 89829;24450;170568;24253 socs3;hmgcs2;dmbt1;cebpb SOCS3_32863;HMGCS2_8812;DMBT1_32993;CEBPB_32843,CEBPB_8282 24253(-0.009836) 384.7331825 363.58099999999996 2.64673 391.2914508868377 325.47481189522165 390.7456500064169 239.7855675 234.70935 1.09657 245.00601247633813 199.69928537593552 242.46410637643382 960.9145699999999 744.0894999999999 8.73928 1079.3909940336384 837.0818860671654 1103.5011377509493 809.124;106.351;2.64673;620.8109999999999 488.627;59.8697;1.09657;409.549 2346.74;208.329;8.73928;1279.85 2 3 2 89829;170568 SOCS3_32863;DMBT1_32993 405.88536500000004 405.88536500000004 570.2655464898143 244.861785 244.861785 344.73607308779344 1177.7396399999998 1177.7396399999998 1653.2161635310308 809.124;2.64673 488.627;1.09657 2346.74;8.73928 2 24450;24253 HMGCS2_8812;CEBPB_32843,CEBPB_8282 363.58099999999996 363.58099999999996 363.77815464923117 234.70935 234.70935 247.26060427056504 744.0894999999999 744.0894999999999 757.6797652837905 106.351;620.8109999999999 59.8697;409.549 208.329;1279.85 0 Exp 4,2(0.4);Linear,3(0.6) 1.8092655558340334 9.206801295280457 1.5669527053833008 2.578549861907959 0.4167297929065787 1.671766996383667 1.26756063089897 768.198804369101 -0.32032472681135005 479.8914597268114 -96.88860415296563 2018.7177441529655 CONFLICT 0.5 0.5 0.0 GO:0071345 6 cellular response to cytokine stimulus 172 189 6 6 6 5 5 5 33 184 2325 0.94201 0.14659 0.19881 2.65 89829;114519;24587;60628;24253 socs3;nfil3;nefh;cxcr4;cebpb SOCS3_32863;NFIL3_9304;NEFH_33218;CXCR4_8411;CEBPB_32843,CEBPB_8282 24253(-0.009836) 310.2512000000009 121.321 1.65461E-12 378.6580563750088 377.7820150420365 384.2759744209752 196.14552000000091 82.5516 1.65461E-12 235.0192386338862 236.67891320154567 234.5690883427508 771.2760000000009 229.79 1.65462E-12 1027.5790423758156 972.7453465121569 1097.1760699757901 809.124;121.321;2.95157E-12;1.65461E-12;620.8109999999999 488.627;82.5516;2.95157E-12;1.65461E-12;409.549 2346.74;229.79;2.95158E-12;1.65462E-12;1279.85 1 5 1 89829 SOCS3_32863 809.124 809.124 488.627 488.627 2346.74 2346.74 809.124 488.627 2346.74 4 114519;24587;60628;24253 NFIL3_9304;NEFH_33218;CXCR4_8411;CEBPB_32843,CEBPB_8282 185.53300000000112 60.66050000000148 295.7674234969081 123.02515000000115 41.275800000001475 194.9396487236232 377.4100000000011 114.89500000000147 611.3008626963748 121.321;2.95157E-12;1.65461E-12;620.8109999999999 82.5516;2.95157E-12;1.65461E-12;409.549 229.79;2.95158E-12;1.65462E-12;1279.85 0 Hill,2(0.34);Linear,3(0.5);Poly 2,1(0.17) 1.8640665722531264 11.3259437084198 1.5669527053833008 2.444005012512207 0.33894981837741384 1.7424405813217163 -21.657220478726117 642.159620478728 -9.857925493399875 402.1489654934017 -129.4367436745316 1671.9887436745335 DOWN 0.2 0.8 0.0 GO:0042594 4 response to starvation 75 79 4 4 4 2 2 2 36 77 2432 0.88827 0.33105 0.33105 2.53 24450;25612 hmgcs2;asns HMGCS2_8812;ASNS_8091 132.058 132.058 106.351 36.35518804792511 123.97230025243417 34.51003647034338 79.718 79.718 59.8697 28.06973505004984 73.4750547205193 26.64509887868345 289.774 289.774 208.329 115.18062358747675 264.15686007933647 109.33480843066542 106.351;157.765 59.8697;99.5663 208.329;371.219 1 1 1 25612 ASNS_8091 157.765 157.765 99.5663 99.5663 371.219 371.219 157.765 99.5663 371.219 1 24450 HMGCS2_8812 106.351 106.351 59.8697 59.8697 208.329 208.329 106.351 59.8697 208.329 0 Exp 4,1(0.5);Poly 2,1(0.5) 2.0310296299788644 4.1783177852630615 1.5997679233551025 2.578549861907959 0.6921033460536394 2.0891588926315308 81.67228000000001 182.44371999999998 40.81533200000001 118.620668 130.14180000000002 449.4062 CONFLICT 0.5 0.5 0.0 GO:0031103 7 axon regeneration 17 18 2 2 2 2 2 2 36 16 2493 0.99786 0.028537 0.028537 11.11 338475;24587 nrep;nefh NREP_9364;NEFH_33218 57.08900000000148 57.08900000000148 2.95157E-12 80.73603806231553 82.24216192741267 72.47720146436758 39.54075000000148 39.54075000000148 2.95157E-12 55.91906491640187 56.96223027608396 50.198863245146356 102.11450000000148 102.11450000000148 2.95158E-12 144.41171081494534 147.10569889360022 129.6392157671925 0.0 2.95157E-12 0.5 57.08900000000148 114.178;2.95157E-12 79.0815;2.95157E-12 204.229;2.95158E-12 0 2 0 2 338475;24587 NREP_9364;NEFH_33218 57.08900000000148 57.08900000000148 80.73603806231553 39.54075000000148 39.54075000000148 55.91906491640187 102.11450000000148 102.11450000000148 144.41171081494534 114.178;2.95157E-12 79.0815;2.95157E-12 204.229;2.95158E-12 0 Hill,1(0.5);Poly 2,1(0.5) 2.0215718948874306 4.116159081459045 1.6721540689468384 2.444005012512207 0.5457810362603074 2.0580795407295227 -54.8054399999956 168.98343999999855 -37.95911999999562 117.04061999999858 -98.02991999999561 302.25891999999857 DOWN 0.0 1.0 0.0 GO:0051171 5 regulation of nitrogen compound metabolic process 917 985 36 32 23 23 15 15 23 970 1539 0.6106 0.52119 1.0 1.52 24522;360772;362246;360243;363328;89829;299276;25106;363140;316351;114519;83928;361921;60628;24253 zfp354a;zfand2a;tp53inp2;top2a;ticam1;socs3;serpina3m;rgn;rassf1;npas2;nfil3;fetub;ect2;cxcr4;cebpb ZFP354A_10203;ZFAND2A_10197;TP53INP2_32755;TOP2A_10059;TICAM1_10015;SOCS3_32863;SERPINA3M_9809;RGN_9699;RASSF1_32475;NPAS2_9350;NFIL3_9304;FETUB_33027;ECT2_8523;CXCR4_8411;CEBPB_32843,CEBPB_8282 24253(-0.009836) 473.5293800000001 545.901 1.65461E-12 364.81915125366686 532.5975240906931 353.18576928387535 305.8514513333335 382.164 1.65461E-12 238.64922483184066 347.19204196010304 234.92274224059625 1048.7822133333334 976.618 1.65462E-12 907.282414004736 1111.574285361098 846.8968074931654 99.2226;946.037;827.265;12.3342;811.122;809.124;466.86;752.835;903.848;155.028;121.321;545.901;31.2319;1.65461E-12;620.8109999999999 71.0566;687.617;495.492;3.46407;489.389;488.627;296.126;458.716;608.514;98.033;82.5516;382.164;16.4725;1.65461E-12;409.549 163.536;1292.08;2498.6;46.5267;2362.87;2346.74;918.743;1994.77;1171.72;382.695;229.79;976.618;67.1945;1.65462E-12;1279.85 4 12 4 360772;89829;363140;83928 ZFAND2A_10197;SOCS3_32863;RASSF1_32475;FETUB_33027 801.2275 856.486 179.58724400227734 541.7304999999999 548.5705 134.19433220644422 1446.7894999999999 1231.9 613.8866347795823 946.037;809.124;903.848;545.901 687.617;488.627;608.514;382.164 1292.08;2346.74;1171.72;976.618 11 24522;362246;360243;363328;299276;25106;316351;114519;361921;60628;24253 ZFP354A_10203;TP53INP2_32755;TOP2A_10059;TICAM1_10015;SERPINA3M_9809;RGN_9699;NPAS2_9350;NFIL3_9304;ECT2_8523;CXCR4_8411;CEBPB_32843,CEBPB_8282 354.3664272727274 155.028 343.6284789332224 220.07725181818202 98.033 209.72337258018155 904.052290909091 382.695 976.1985169900336 99.2226;827.265;12.3342;811.122;466.86;752.835;155.028;121.321;31.2319;1.65461E-12;620.8109999999999 71.0566;495.492;3.46407;489.389;296.126;458.716;98.033;82.5516;16.4725;1.65461E-12;409.549 163.536;2498.6;46.5267;2362.87;918.743;1994.77;382.695;229.79;67.1945;1.65462E-12;1279.85 0 Exp 2,3(0.19);Exp 4,1(0.07);Hill,2(0.13);Linear,5(0.32);Poly 2,5(0.32) 1.8597526282981738 30.421651244163513 1.5054508447647095 2.846071243286133 0.4373185830693895 1.72762531042099 288.9054163680912 658.153343631909 185.07828014775376 426.62462251891327 589.6339618463655 1507.9304648203017 DOWN 0.26666666666666666 0.7333333333333333 0.0 GO:0043270 6 positive regulation of ion transport 88 94 3 3 3 3 3 3 35 91 2418 0.95075 0.16314 0.16314 3.19 25106;60628;24253 rgn;cxcr4;cebpb RGN_9699;CXCR4_8411;CEBPB_32843,CEBPB_8282 24253(-0.009836) 457.8820000000005 620.8109999999999 1.65461E-12 401.9944385025734 489.6162417207242 377.87712260290465 289.42166666666725 409.549 1.65461E-12 251.84920949713702 311.1855162171394 237.59538975816972 1091.5400000000006 1279.85 1.65462E-12 1010.6296702056583 1147.288476157961 945.7475889671592 752.835;1.65461E-12;620.8109999999999 458.716;1.65461E-12;409.549 1994.77;1.65462E-12;1279.85 0 4 0 3 25106;60628;24253 RGN_9699;CXCR4_8411;CEBPB_32843,CEBPB_8282 457.8820000000005 620.8109999999999 401.9944385025734 289.42166666666725 409.549 251.84920949713702 1091.5400000000006 1279.85 1010.6296702056583 752.835;1.65461E-12;620.8109999999999 458.716;1.65461E-12;409.549 1994.77;1.65462E-12;1279.85 0 Exp 2,1(0.25);Hill,1(0.25);Linear,2(0.5) 1.6731347121491655 6.698049187660217 1.5669527053833008 1.744480013847351 0.07767275694806534 1.6933082342147827 2.982469326901878 912.7815306730993 4.42745722586875 574.4158761074657 -52.09513180274871 2235.1751318027495 DOWN 0.0 1.0 0.0 GO:0006644 5 phospholipid metabolic process 58 63 3 3 2 3 2 2 36 61 2448 0.93411 0.24161 0.24161 3.17 89829;24450 socs3;hmgcs2 SOCS3_32863;HMGCS2_8812 457.7375 457.7375 106.351 496.93555393481364 398.6663733256425 489.863398052298 274.24835 274.24835 59.8697 303.1771943132349 238.2094344741396 298.86251736724165 1277.5345 1277.5345 208.329 1512.0849190639062 1097.7917565211817 1490.5656291468401 809.124;106.351 488.627;59.8697 2346.74;208.329 1 1 1 89829 SOCS3_32863 809.124 809.124 488.627 488.627 2346.74 2346.74 809.124 488.627 2346.74 1 24450 HMGCS2_8812 106.351 106.351 59.8697 59.8697 208.329 208.329 106.351 59.8697 208.329 0 Exp 4,1(0.5);Linear,1(0.5) 2.1184218517312807 4.3189510107040405 1.7404011487960815 2.578549861907959 0.5926606386841867 2.1594755053520203 -230.98003999999997 1146.45504 -145.93380399999995 694.4305039999999 -818.1082799999992 3373.177279999999 CONFLICT 0.5 0.5 0.0 GO:0009719 3 response to endogenous stimulus 481 515 17 14 12 12 9 9 29 506 2003 0.77551 0.3569 0.54621 1.75 360243;363328;89829;24314;24587;24450;266674;24253;25612 top2a;ticam1;socs3;nqo1;nefh;hmgcs2;cyp4a8;cebpb;asns TOP2A_10059;TICAM1_10015;SOCS3_32863;NQO1_33055;NEFH_33218;HMGCS2_8812;CYP4A8_32747;CEBPB_32843,CEBPB_8282;ASNS_8091 24253(-0.009836) 292.7463222222225 106.351 2.95157E-12 348.313177505186 287.13308765341407 347.7145527038588 181.09598555555587 59.8697 2.95157E-12 214.51830486356576 175.01091835695777 213.98498177007042 756.4191000000003 208.329 2.95158E-12 986.2326956088148 756.2796531719965 997.9766898743703 12.3342;811.122;809.124;40.5511;2.95157E-12;106.351;76.6586;620.8109999999999;157.765 3.46407;489.389;488.627;21.5832;2.95157E-12;59.8697;57.8156;409.549;99.5663 46.5267;2362.87;2346.74;79.3552;2.95158E-12;208.329;112.882;1279.85;371.219 4 6 4 89829;24314;266674;25612 SOCS3_32863;NQO1_33055;CYP4A8_32747;ASNS_8091 271.024675 117.2118 362.06577553015023 166.89802500000002 78.69095 216.83977829623996 727.54905 242.0505 1087.308801066258 809.124;40.5511;76.6586;157.765 488.627;21.5832;57.8156;99.5663 2346.74;79.3552;112.882;371.219 5 360243;363328;24587;24450;24253 TOP2A_10059;TICAM1_10015;NEFH_33218;HMGCS2_8812;CEBPB_32843,CEBPB_8282 310.1236400000006 106.351 378.78242562894536 192.4543540000006 59.8697 237.5052450016984 779.5151400000007 208.329 1028.1679213542634 12.3342;811.122;2.95157E-12;106.351;620.8109999999999 3.46407;489.389;2.95157E-12;59.8697;409.549 46.5267;2362.87;2.95158E-12;208.329;1279.85 0 Exp 4,2(0.2);Hill,2(0.2);Linear,4(0.4);Poly 2,2(0.2) 1.955650418096728 20.14179015159607 1.5415632724761963 2.846071243286133 0.526759973629553 1.7060840725898743 65.18171291883439 520.3109315256107 40.94402637802625 321.2479447330855 112.08040553557464 1400.7577944644258 CONFLICT 0.4444444444444444 0.5555555555555556 0.0 GO:0048522 5 positive regulation of cellular process 1060 1140 38 35 26 27 18 18 20 1122 1387 0.68928 0.43377 0.74561 1.58 360772;362246;360243;363328;89829;25106;363140;24314;316351;114519;315740;499271;361921;170568;24296;60628;24253;25612 zfand2a;tp53inp2;top2a;ticam1;socs3;rgn;rassf1;nqo1;npas2;nfil3;kif23;itgax;ect2;dmbt1;cyp1a1;cxcr4;cebpb;asns ZFAND2A_10197;TP53INP2_32755;TOP2A_10059;TICAM1_10015;SOCS3_32863;RGN_9699;RASSF1_32475;NQO1_33055;NPAS2_9350;NFIL3_9304;KIF23_32798;ITGAX_32980;ECT2_8523;DMBT1_32993;CYP1A1_8415;CXCR4_8411;CEBPB_32843,CEBPB_8282;ASNS_8091 24253(-0.009836) 355.5337183333334 151.666 1.65461E-12 381.69232321034696 356.9063093455665 388.0584536934182 227.74043444444456 96.60849999999999 1.65461E-12 248.42459287103836 231.43368009085432 255.61066780238775 808.8718933333334 356.102 1.65462E-12 929.484471894249 760.8311677856028 890.7278932874311 946.037;827.265;12.3342;811.122;809.124;752.835;903.848;40.5511;155.028;121.321;10.3381;148.304;31.2319;2.64673;49.0449;1.65461E-12;620.8109999999999;157.765 687.617;495.492;3.46407;489.389;488.627;458.716;608.514;21.5832;98.033;82.5516;4.23628;95.184;16.4725;1.09657;39.2363;1.65461E-12;409.549;99.5663 1292.08;2498.6;46.5267;2362.87;2346.74;1994.77;1171.72;79.3552;382.695;229.79;21.7065;340.985;67.1945;8.73928;64.8529;1.65462E-12;1279.85;371.219 7 12 7 360772;89829;363140;24314;170568;24296;25612 ZFAND2A_10197;SOCS3_32863;RASSF1_32475;NQO1_33055;DMBT1_32993;CYP1A1_8415;ASNS_8091 415.5738185714286 157.765 444.7179374627327 278.0343385714286 99.5663 303.49659261168614 762.1009114285714 371.219 878.6718751786276 946.037;809.124;903.848;40.5511;2.64673;49.0449;157.765 687.617;488.627;608.514;21.5832;1.09657;39.2363;99.5663 1292.08;2346.74;1171.72;79.3552;8.73928;64.8529;371.219 11 362246;360243;363328;25106;316351;114519;315740;499271;361921;60628;24253 TP53INP2_32755;TOP2A_10059;TICAM1_10015;RGN_9699;NPAS2_9350;NFIL3_9304;KIF23_32798;ITGAX_32980;ECT2_8523;CXCR4_8411;CEBPB_32843,CEBPB_8282 317.32638181818197 148.304 353.3804943823096 195.73522272727288 95.184 216.2212141714977 838.6352454545456 340.985 1001.4769509245194 827.265;12.3342;811.122;752.835;155.028;121.321;10.3381;148.304;31.2319;1.65461E-12;620.8109999999999 495.492;3.46407;489.389;458.716;98.033;82.5516;4.23628;95.184;16.4725;1.65461E-12;409.549 2498.6;46.5267;2362.87;1994.77;382.695;229.79;21.7065;340.985;67.1945;1.65462E-12;1279.85 0 Exp 2,1(0.06);Exp 4,3(0.16);Exp 5,1(0.06);Hill,2(0.11);Linear,5(0.27);Poly 2,7(0.37) 2.0489747900464717 43.598076939582825 1.5415632724761963 8.822484970092773 1.6378945308965638 1.7404011487960815 179.20086135499605 531.8665753116709 112.97412781246705 342.5067410764219 379.47197491843986 1238.2718117482266 DOWN 0.3888888888888889 0.6111111111111112 0.0 GO:0042110 5 T cell activation 79 84 3 3 3 3 3 3 35 81 2428 0.96536 0.12808 0.12808 3.57 499271;60628;24253 itgax;cxcr4;cebpb ITGAX_32980;CXCR4_8411;CEBPB_32843,CEBPB_8282 24253(-0.009836) 256.3716666666672 148.304 1.65461E-12 324.2075567662372 240.7736919532327 275.4612354360122 168.24433333333388 95.184 1.65461E-12 214.32674840143736 157.28979360385173 182.50690415001282 540.2783333333339 340.985 1.65462E-12 662.7913549212394 516.9533012379645 557.8317004803446 148.304;1.65461E-12;620.8109999999999 95.184;1.65461E-12;409.549 340.985;1.65462E-12;1279.85 0 4 0 3 499271;60628;24253 ITGAX_32980;CXCR4_8411;CEBPB_32843,CEBPB_8282 256.3716666666672 148.304 324.2075567662372 168.24433333333388 95.184 214.32674840143736 540.2783333333339 340.985 662.7913549212394 148.304;1.65461E-12;620.8109999999999 95.184;1.65461E-12;409.549 340.985;1.65462E-12;1279.85 0 Hill,1(0.25);Linear,2(0.5);Poly 2,1(0.25) 1.7091395025334926 6.850492477416992 1.5669527053833008 1.8672927618026733 0.12626249418377417 1.708123505115509 -110.5037208710367 623.2470542043711 -74.28921419951601 410.77788086618375 -209.74069034012166 1290.2973570067893 DOWN 0.0 1.0 0.0 GO:1903052 9 positive regulation of proteolysis involved in cellular protein catabolic process 37 38 4 4 2 4 2 2 36 36 2473 0.98196 0.10898 0.10898 5.26 360772;25106 zfand2a;rgn ZFAND2A_10197;RGN_9699 849.436 849.436 752.835 136.61444433880368 889.7344154599658 124.15950154874338 573.1665 573.1665 458.716 161.85744932038148 620.91107612862 147.1011380006862 1643.425 1643.425 1292.08 496.87686407197475 1496.856674829642 451.5773136058909 0.5 849.436 946.037;752.835 687.617;458.716 1292.08;1994.77 1 1 1 360772 ZFAND2A_10197 946.037 946.037 687.617 687.617 1292.08 1292.08 946.037 687.617 1292.08 1 25106 RGN_9699 752.835 752.835 458.716 458.716 1994.77 1994.77 752.835 458.716 1994.77 0 Exp 2,1(0.5);Poly 2,1(0.5) 2.0928100155156932 4.268924236297607 1.7148494720458984 2.554074764251709 0.5934218950619905 2.1344621181488037 660.0980400000001 1038.77396 348.8435200000001 797.48948 954.7887999999999 2332.0612 CONFLICT 0.5 0.5 0.0 GO:0045595 5 regulation of cell differentiation 433 456 11 11 8 8 6 6 32 450 2059 0.46641 0.6994 1.0 1.32 89829;338475;361921;170568;60628;24253 socs3;nrep;ect2;dmbt1;cxcr4;cebpb SOCS3_32863;NREP_9364;ECT2_8523;DMBT1_32993;CXCR4_8411;CEBPB_32843,CEBPB_8282 24253(-0.009836) 262.9986050000003 72.70495 1.65461E-12 357.5185030586881 301.5236123426158 373.3191403184254 165.80442833333362 47.777 1.65461E-12 222.7404351098397 188.9163572568355 229.1005115567526 651.1254633333336 135.71175 1.65462E-12 964.1285595168184 773.8059814526675 1048.717895210563 809.124;114.178;31.2319;2.64673;1.65461E-12;620.8109999999999 488.627;79.0815;16.4725;1.09657;1.65461E-12;409.549 2346.74;204.229;67.1945;8.73928;1.65462E-12;1279.85 2 5 2 89829;170568 SOCS3_32863;DMBT1_32993 405.88536500000004 405.88536500000004 570.2655464898143 244.861785 244.861785 344.73607308779344 1177.7396399999998 1177.7396399999998 1653.2161635310308 809.124;2.64673 488.627;1.09657 2346.74;8.73928 4 338475;361921;60628;24253 NREP_9364;ECT2_8523;CXCR4_8411;CEBPB_32843,CEBPB_8282 191.5552250000004 72.70495 290.1980519595809 126.27575000000041 47.777 191.8969776965838 387.8183750000004 135.71175 600.7296229920984 114.178;31.2319;1.65461E-12;620.8109999999999 79.0815;16.4725;1.65461E-12;409.549 204.229;67.1945;1.65462E-12;1279.85 0 Exp 4,2(0.29);Hill,1(0.15);Linear,3(0.43);Poly 2,1(0.15) 1.734538715004327 12.19870674610138 1.5669527053833008 2.1538212299346924 0.19090996146636494 1.6721540689468384 -23.075777658501067 549.0729876585015 -12.425039294173757 344.03389596084094 -120.33805563851729 1422.5889823051843 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0009611 4 response to wounding 115 120 6 6 6 4 4 4 34 116 2393 0.96918 0.10093 0.10093 3.33 338475;24587;170568;24296 nrep;nefh;dmbt1;cyp1a1 NREP_9364;NEFH_33218;DMBT1_32993;CYP1A1_8415 41.46740750000074 25.845814999999998 2.95157E-12 53.45041172469559 49.18258631131141 50.603814366474246 29.853592500000737 20.166435 2.95157E-12 37.54830402330887 35.85217485421502 35.41365907942988 69.45529500000075 36.79609000000001 2.95158E-12 94.33204842501813 80.41821194191309 90.33247830736511 114.178;2.95157E-12;2.64673;49.0449 79.0815;2.95157E-12;1.09657;39.2363 204.229;2.95158E-12;8.73928;64.8529 2 2 2 170568;24296 DMBT1_32993;CYP1A1_8415 25.845814999999998 25.845814999999998 32.808460641646235 20.166435 20.166435 26.968861715624 36.79609000000001 36.79609000000001 39.67832121892507 2.64673;49.0449 1.09657;39.2363 8.73928;64.8529 2 338475;24587 NREP_9364;NEFH_33218 57.08900000000148 57.08900000000148 80.73603806231553 39.54075000000148 39.54075000000148 55.91906491640187 102.11450000000148 102.11450000000148 144.41171081494534 114.178;2.95157E-12 79.0815;2.95157E-12 204.229;2.95158E-12 0 Exp 4,1(0.25);Hill,1(0.25);Poly 2,2(0.5) 2.776873453869446 14.587774634361267 1.6491305828094482 8.822484970092773 3.470078782123065 2.0580795407295227 -10.913995990200938 93.84881099020242 -6.9437454428419585 66.65093044284343 -22.990112456517025 161.9007024565185 CONFLICT 0.5 0.5 0.0 GO:0001822 5 kidney development 48 53 6 6 4 4 4 4 34 49 2460 0.99904 0.0073089 0.0073089 7.55 24522;25106;24450;266674 zfp354a;rgn;hmgcs2;cyp4a8 ZFP354A_10203;RGN_9699;HMGCS2_8812;CYP4A8_32747 258.7668 102.7868 76.6586 329.62185940951593 212.22159497113054 282.61010950814403 161.864475 65.46315 57.8156 197.98653201073006 129.36847055938412 172.13681629322156 619.87925 185.9325 112.882 917.4227589718839 495.3392980070776 784.1036041542528 1.5 102.7868 99.2226;752.835;106.351;76.6586 71.0566;458.716;59.8697;57.8156 163.536;1994.77;208.329;112.882 1 3 1 266674 CYP4A8_32747 76.6586 76.6586 57.8156 57.8156 112.882 112.882 76.6586 57.8156 112.882 3 24522;25106;24450 ZFP354A_10203;RGN_9699;HMGCS2_8812 319.46953333333335 106.351 375.3224271157445 196.54743333333332 71.0566 227.11352820548436 788.8783333333334 208.329 1044.5729448029626 99.2226;752.835;106.351 71.0566;458.716;59.8697 163.536;1994.77;208.329 0 Exp 2,1(0.25);Exp 4,1(0.25);Poly 2,2(0.5) 1.8897323197353624 7.699873089790344 1.5729032754898071 2.578549861907959 0.44856144983996454 1.774209976196289 -64.26262222132561 581.7962222213256 -32.162326370515416 355.89127637051547 -279.19505379244606 1518.953553792446 DOWN 0.25 0.75 0.0 GO:0043549 7 regulation of kinase activity 234 250 11 9 5 7 3 3 35 247 2262 0.47906 0.73655 1.0 1.2 89829;25106;361921 socs3;rgn;ect2 SOCS3_32863;RGN_9699;ECT2_8523 531.0636333333333 752.835 31.2319 433.7809748196702 695.8999622409389 311.61440752033167 321.27183333333335 458.716 16.4725 264.38729580027734 421.0057795022239 189.45505628563828 1469.5681666666667 1994.77 67.1945 1227.17547479775 1966.5059827765685 905.3633285098991 809.124;752.835;31.2319 488.627;458.716;16.4725 2346.74;1994.77;67.1945 1 2 1 89829 SOCS3_32863 809.124 809.124 488.627 488.627 2346.74 2346.74 809.124 488.627 2346.74 2 25106;361921 RGN_9699;ECT2_8523 392.03345 392.03345 510.2504453352344 237.59425000000002 237.59425000000002 312.7133777856729 1030.98225 1030.98225 1363.00170729905 752.835;31.2319 458.716;16.4725 1994.77;67.1945 0 Exp 2,1(0.34);Exp 4,1(0.34);Linear,1(0.34) 1.8593522468924242 5.609071850776672 1.7148494720458984 2.1538212299346924 0.24639577103289853 1.7404011487960815 40.19425067364256 1021.9330159930241 22.08944358814307 620.4542230785237 80.88838886058693 2858.247944472747 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0044249 4 cellular biosynthetic process 372 415 16 16 13 13 11 11 27 404 2105 0.98595 0.034834 0.044211 2.65 25044;25106;114519;24450;60671;266674;29277;24296;25612;25748;54223 sds;rgn;nfil3;hmgcs2;gulo;cyp4a8;cyp2c11;cyp1a1;asns;alas2;adcy4 SDS_9798;RGN_9699;NFIL3_9304;HMGCS2_8812;GULO_8772;CYP4A8_32747;CYP2C11_32593;CYP1A1_8415;ASNS_8091;ALAS2_8019;ADCY4_7988 273.6556 157.765 49.0449 266.6314030363303 223.96523099463843 248.98954648639804 168.9140181818182 99.5663 37.2697 158.97678019600107 136.94605769822877 145.78083088597387 695.1819 368.944 64.8529 746.8419062674978 556.1743066002514 710.6802432754936 553.681;752.835;121.321;106.351;193.989;76.6586;216.743;49.0449;157.765;65.3911;716.432 377.484;458.716;82.5516;59.8697;112.274;57.8156;139.563;39.2363;99.5663;37.2697;393.708 1035.66;1994.77;229.79;208.329;1039.83;112.882;368.944;64.8529;371.219;133.644;2087.08 5 6 5 25044;60671;266674;24296;25612 SDS_9798;GULO_8772;CYP4A8_32747;CYP1A1_8415;ASNS_8091 206.2277 157.765 202.92658711989915 137.27524 99.5663 137.5433955915841 524.88878 371.219 482.45432378981945 553.681;193.989;76.6586;49.0449;157.765 377.484;112.274;57.8156;39.2363;99.5663 1035.66;1039.83;112.882;64.8529;371.219 6 25106;114519;24450;29277;25748;54223 RGN_9699;NFIL3_9304;HMGCS2_8812;CYP2C11_32593;ALAS2_8019;ADCY4_7988 329.8455166666667 169.03199999999998 317.6569857278786 195.27966666666666 111.0573 183.24163161632973 837.0928333333333 299.367 936.0393816293024 752.835;121.321;106.351;216.743;65.3911;716.432 458.716;82.5516;59.8697;139.563;37.2697;393.708 1994.77;229.79;208.329;368.944;133.644;2087.08 0 Exp 2,3(0.28);Exp 4,1(0.1);Exp 5,1(0.1);Linear,1(0.1);Poly 2,5(0.46) 2.3534358227277417 33.29535377025604 1.5452189445495605 8.822484970092773 2.7690618723150067 1.7132161855697632 116.08651004116646 431.22468995883355 74.96474478488003 262.8632915787563 253.82653760236246 1136.5372623976373 CONFLICT 0.45454545454545453 0.5454545454545454 0.0 GO:0009628 3 response to abiotic stimulus 422 443 19 18 15 12 10 10 28 433 2076 0.94699 0.10957 0.19152 2.26 24522;360243;89829;24314;24450;361921;24296;60628;25612;25748 zfp354a;top2a;socs3;nqo1;hmgcs2;ect2;cyp1a1;cxcr4;asns;alas2 ZFP354A_10203;TOP2A_10059;SOCS3_32863;NQO1_33055;HMGCS2_8812;ECT2_8523;CYP1A1_8415;CXCR4_8411;ASNS_8091;ALAS2_8019 137.10158000000018 57.217999999999996 1.65461E-12 240.88079664281057 149.86230792600085 251.80996632323914 83.71453700000016 38.253 1.65461E-12 145.6402237213069 91.23210754206883 152.03316529750882 348.13973000000016 106.4996 1.65462E-12 710.0992225533508 381.16643808486924 746.053880277183 99.2226;12.3342;809.124;40.5511;106.351;31.2319;49.0449;1.65461E-12;157.765;65.3911 71.0566;3.46407;488.627;21.5832;59.8697;16.4725;39.2363;1.65461E-12;99.5663;37.2697 163.536;46.5267;2346.74;79.3552;208.329;67.1945;64.8529;1.65462E-12;371.219;133.644 4 6 4 89829;24314;24296;25612 SOCS3_32863;NQO1_33055;CYP1A1_8415;ASNS_8091 264.12125000000003 103.40494999999999 367.2333943248126 162.2532 69.40129999999999 220.1292887855226 715.5417749999999 225.2871 1096.5848793543598 809.124;40.5511;49.0449;157.765 488.627;21.5832;39.2363;99.5663 2346.74;79.3552;64.8529;371.219 6 24522;360243;24450;361921;60628;25748 ZFP354A_10203;TOP2A_10059;HMGCS2_8812;ECT2_8523;CXCR4_8411;ALAS2_8019 52.421800000000275 48.311499999999995 44.879725682717414 31.35542833333361 26.8711 29.687767316367797 103.20503333333362 100.41925 78.45747317385768 99.2226;12.3342;106.351;31.2319;1.65461E-12;65.3911 71.0566;3.46407;59.8697;16.4725;1.65461E-12;37.2697 163.536;46.5267;208.329;67.1945;1.65462E-12;133.644 0 Exp 4,3(0.3);Exp 5,1(0.1);Hill,2(0.2);Linear,1(0.1);Poly 2,3(0.3) 2.3656427008596337 27.61217176914215 1.5997679233551025 8.822484970092773 2.174728395579333 1.993695855140686 -12.19788454947576 286.4010445494761 -6.55420887557932 173.98328287557965 -91.98432796474543 788.2637879647457 DOWN 0.4 0.6 0.0 GO:0022607 5 cellular component assembly 355 395 14 14 10 10 7 7 31 388 2121 0.77334 0.37431 0.64986 1.77 362246;25044;24587;291885;315740;361308;361921 tp53inp2;sds;nefh;mcm5;kif23;kif20a;ect2 TP53INP2_32755;SDS_9798;NEFH_33218;MCM5_9209;KIF23_32798;KIF20A_8961;ECT2_8523 210.04161428571473 31.2319 2.95157E-12 337.78458352758577 310.78252008114555 391.2439098429913 131.27225857142898 15.546 2.95157E-12 211.34656565022945 192.1455891570937 240.80791243657407 536.541528571429 67.1945 2.95158E-12 941.2814951943893 837.0911098969733 1140.7345229549278 827.265;553.681;2.95157E-12;12.5006;10.3381;35.2747;31.2319 495.492;377.484;2.95157E-12;9.67503;4.23628;15.546;16.4725 2498.6;1035.66;2.95158E-12;36.0856;21.7065;96.5441;67.1945 1 6 1 25044 SDS_9798 553.681 553.681 377.484 377.484 1035.66 1035.66 553.681 377.484 1035.66 6 362246;24587;291885;315740;361308;361921 TP53INP2_32755;NEFH_33218;MCM5_9209;KIF23_32798;KIF20A_8961;ECT2_8523 152.76838333333384 21.86625 330.7026410227132 90.23696833333383 12.610515 198.6356629540842 453.35511666666713 51.64005 1002.5393753761082 827.265;2.95157E-12;12.5006;10.3381;35.2747;31.2319 495.492;2.95157E-12;9.67503;4.23628;15.546;16.4725 2498.6;2.95158E-12;36.0856;21.7065;96.5441;67.1945 0 Exp 4,2(0.29);Exp 5,2(0.29);Hill,1(0.15);Linear,2(0.29) 1.81356299188911 12.867117762565613 1.5452189445495605 2.444005012512207 0.33873385347397056 1.7765510082244873 -40.19270703742998 460.2759356088593 -25.295468312837045 287.83998545569506 -160.7695614261612 1233.8526185690193 DOWN 0.14285714285714285 0.8571428571428571 0.0 GO:0050896 2 response to stimulus 1203 1308 46 43 35 32 26 26 12 1282 1227 0.98962 0.024208 0.048348 1.99 24522;360772;360243;363328;89829;25044;363140;338475;24314;316351;114519;24587;24567;291885;499271;24450;361921;170568;266674;266684;24296;60628;170945;24253;25612;25748 zfp354a;zfand2a;top2a;ticam1;socs3;sds;rassf1;nrep;nqo1;npas2;nfil3;nefh;mt1;mcm5;itgax;hmgcs2;ect2;dmbt1;cyp4a8;cyp2d1;cyp1a1;cxcr4;chrna2;cebpb;asns;alas2 ZFP354A_10203;ZFAND2A_10197;TOP2A_10059;TICAM1_10015;SOCS3_32863;SDS_9798;RASSF1_32475;NREP_9364;NQO1_33055;NPAS2_9350;NFIL3_9304;NEFH_33218;MT1A_9255;MCM5_9209;ITGAX_32980;HMGCS2_8812;ECT2_8523;DMBT1_32993;CYP4A8_32747;CYP2D1_32660;CYP1A1_8415;CXCR4_8411;CHRNA2_32401;CEBPB_32843,CEBPB_8282;ASNS_8091;ALAS2_8019 24253(-0.009836) 258.63529730769244 117.7495 1.65461E-12 316.7085892342708 273.5604578456936 332.54740018238937 169.9210719230771 80.81655 1.65461E-12 211.0129172320571 179.83576903803598 223.35270676913038 560.2746992307694 219.0595 1.65462E-12 698.1732310259255 573.1082223411329 693.7567449904634 99.2226;946.037;12.3342;811.122;809.124;553.681;903.848;114.178;40.5511;155.028;121.321;2.95157E-12;168.588;12.5006;148.304;106.351;31.2319;2.64673;76.6586;126.747;49.0449;1.65461E-12;592.031;620.8109999999999;157.765;65.3911 71.0566;687.617;3.46407;489.389;488.627;377.484;608.514;79.0815;21.5832;98.033;82.5516;2.95157E-12;103.554;9.67503;95.184;59.8697;16.4725;1.09657;57.8156;85.1532;39.2363;1.65461E-12;396.105;409.549;99.5663;37.2697 163.536;1292.08;46.5267;2362.87;2346.74;1035.66;1171.72;204.229;79.3552;382.695;229.79;2.95158E-12;1208.95;36.0856;340.985;208.329;67.1945;8.73928;112.882;250.579;64.8529;1.65462E-12;1168.63;1279.85;371.219;133.644 10 17 10 360772;89829;25044;363140;24314;170568;266674;266684;24296;25612 ZFAND2A_10197;SOCS3_32863;SDS_9798;RASSF1_32475;NQO1_33055;DMBT1_32993;CYP4A8_32747;CYP2D1_32660;CYP1A1_8415;ASNS_8091 366.61033299999997 142.256 391.5819886167113 246.66931699999995 92.35974999999999 266.33585859723144 673.382738 310.899 768.233968859213 946.037;809.124;553.681;903.848;40.5511;2.64673;76.6586;126.747;49.0449;157.765 687.617;488.627;377.484;608.514;21.5832;1.09657;57.8156;85.1532;39.2363;99.5663 1292.08;2346.74;1035.66;1171.72;79.3552;8.73928;112.882;250.579;64.8529;371.219 16 24522;360243;363328;338475;316351;114519;24587;24567;291885;499271;24450;361921;60628;170945;24253;25748 ZFP354A_10203;TOP2A_10059;TICAM1_10015;NREP_9364;NPAS2_9350;NFIL3_9304;NEFH_33218;MT1A_9255;MCM5_9209;ITGAX_32980;HMGCS2_8812;ECT2_8523;CXCR4_8411;CHRNA2_32401;CEBPB_32843,CEBPB_8282;ALAS2_8019 191.1509000000003 110.2645 250.0836916821537 121.95341875000028 75.06905 158.96140235043623 489.5821750000003 206.279 666.6634544651348 99.2226;12.3342;811.122;114.178;155.028;121.321;2.95157E-12;168.588;12.5006;148.304;106.351;31.2319;1.65461E-12;592.031;620.8109999999999;65.3911 71.0566;3.46407;489.389;79.0815;98.033;82.5516;2.95157E-12;103.554;9.67503;95.184;59.8697;16.4725;1.65461E-12;396.105;409.549;37.2697 163.536;46.5267;2362.87;204.229;382.695;229.79;2.95158E-12;1208.95;36.0856;340.985;208.329;67.1945;1.65462E-12;1168.63;1279.85;133.644 0 Exp 4,4(0.15);Exp 5,2(0.08);Hill,3(0.12);Linear,6(0.23);Poly 2,12(0.45) 2.016369707261451 59.35810565948486 1.5415632724761963 8.822484970092773 1.3846007231147348 1.7765510082244873 136.89643491573642 380.37415969964854 88.8103178511794 251.03182599497487 291.90554920831306 828.6438492532257 DOWN 0.38461538461538464 0.6153846153846154 0.0 GO:1903827 6 regulation of cellular protein localization 137 147 3 3 2 3 2 2 36 145 2364 0.62278 0.65457 1.0 1.36 362246;361921 tp53inp2;ect2 TP53INP2_32755;ECT2_8523 429.24845 429.24845 31.2319 562.8804030589491 677.9948692975091 439.4141394187724 255.98225000000002 255.98225000000002 16.4725 338.7179367705894 405.66746459557794 264.4210917326313 1282.89725 1282.89725 67.1945 1719.2633168642683 2042.6689378673384 1342.1476510971343 827.265;31.2319 495.492;16.4725 2498.6;67.1945 0 2 0 2 362246;361921 TP53INP2_32755;ECT2_8523 429.24845 429.24845 562.8804030589491 255.98225000000002 255.98225000000002 338.7179367705894 1282.89725 1282.89725 1719.2633168642683 827.265;31.2319 495.492;16.4725 2498.6;67.1945 0 Exp 4,1(0.5);Linear,1(0.5) 1.8411856703657141 3.727751612663269 1.5739303827285767 2.1538212299346924 0.4100447504074565 1.8638758063316345 -350.863988 1209.360888 -213.45685999999995 725.42136 -1099.8801399999998 3665.6746399999997 DOWN 0.0 1.0 0.0 GO:0032386 6 regulation of intracellular transport 104 109 2 2 2 2 2 2 36 107 2402 0.77959 0.48932 0.67672 1.83 24587;361921 nefh;ect2 NEFH_33218;ECT2_8523 15.615950000001476 15.615950000001476 2.95157E-12 22.084288279338047 10.3462907292974 20.78887132930196 8.236250000001476 8.236250000001476 2.95157E-12 11.647816453093316 5.456897404204694 10.964580540149576 33.59725000000148 33.59725000000148 2.95158E-12 47.513686608437375 22.25973547589814 44.72663573259556 2.95157E-12;31.2319 2.95157E-12;16.4725 2.95158E-12;67.1945 0 2 0 2 24587;361921 NEFH_33218;ECT2_8523 15.615950000001476 15.615950000001476 22.084288279338047 8.236250000001476 8.236250000001476 11.647816453093316 33.59725000000148 33.59725000000148 47.513686608437375 2.95157E-12;31.2319 2.95157E-12;16.4725 2.95158E-12;67.1945 0 Exp 4,1(0.5);Hill,1(0.5) 2.294329941838269 4.597826242446899 2.1538212299346924 2.444005012512207 0.20519092045092333 2.2989131212234497 -14.991311999995627 46.22321199999858 -7.906799999995627 24.37929999999858 -32.25335999999563 99.44785999999857 DOWN 0.0 1.0 0.0 GO:0033043 6 regulation of organelle organization 271 282 14 12 7 8 3 3 35 279 2230 0.37929 0.80965 0.79325 1.06 360243;363140;361921 top2a;rassf1;ect2 TOP2A_10059;RASSF1_32475;ECT2_8523 315.80469999999997 31.2319 12.3342 509.3480860595139 517.2808602130723 539.3374731778811 209.48352333333332 16.4725 3.46407 345.6317343566511 346.17388628044927 366.016865136572 428.4804 67.1945 46.5267 643.7473236801301 683.5820150071984 681.0389056967864 12.3342;903.848;31.2319 3.46407;608.514;16.4725 46.5267;1171.72;67.1945 1 2 1 363140 RASSF1_32475 903.848 903.848 608.514 608.514 1171.72 1171.72 903.848 608.514 1171.72 2 360243;361921 TOP2A_10059;ECT2_8523 21.78305 21.78305 13.362691818829017 9.968285 9.968285 9.198349065590524 56.860600000000005 56.860600000000005 14.614341532207316 12.3342;31.2319 3.46407;16.4725 46.5267;67.1945 0 Exp 4,1(0.34);Hill,1(0.34);Poly 2,1(0.34) 2.533942918984012 7.654101133346558 2.1538212299346924 2.846071243286133 0.35740008209643803 2.6542086601257324 -260.5769190114547 892.1863190114548 -181.63560341439455 600.6026500810613 -299.98827360897553 1156.9490736089756 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0022402 3 cell cycle process 177 191 31 29 17 16 8 8 30 183 2326 0.9985 0.0059554 0.0059554 4.19 360243;363140;304951;291885;304477;315740;361308;361921 top2a;rassf1;nuf2;mcm5;kntc1;kif23;kif20a;ect2 TOP2A_10059;RASSF1_32475;NUF2_33136;MCM5_9209;KNTC1_8976;KIF23_32798;KIF20A_8961;ECT2_8523 128.47974 12.62895 9.55312 313.45400187145106 273.04874500326315 431.9942159913749 83.9775575 9.65445 3.46407 212.00375304092708 181.9874059175319 292.0922684627885 189.7332625 43.405 21.7065 397.44972805095716 370.60397624147134 548.8226278615022 12.3342;903.848;9.55312;12.5006;12.7573;10.3381;35.2747;31.2319 3.46407;608.514;4.27871;9.67503;9.63387;4.23628;15.546;16.4725 46.5267;1171.72;37.8054;36.0856;40.2833;21.7065;96.5441;67.1945 1 7 1 363140 RASSF1_32475 903.848 903.848 608.514 608.514 1171.72 1171.72 903.848 608.514 1171.72 7 360243;304951;291885;304477;315740;361308;361921 TOP2A_10059;NUF2_33136;MCM5_9209;KNTC1_8976;KIF23_32798;KIF20A_8961;ECT2_8523 17.712845714285717 12.5006 10.745590733317638 9.04378 9.63387 5.40312472211528 49.449442857142856 40.2833 24.86363238895027 12.3342;9.55312;12.5006;12.7573;10.3381;35.2747;31.2319 3.46407;4.27871;9.67503;9.63387;4.23628;15.546;16.4725 46.5267;37.8054;36.0856;40.2833;21.7065;96.5441;67.1945 0 Exp 4,2(0.25);Exp 5,4(0.5);Hill,1(0.13);Poly 2,1(0.13) 2.0265203640066143 16.530368208885193 1.595955729484558 2.846071243286133 0.4530705527392246 1.8630624413490295 -88.73280130709648 345.69228130709655 -62.93354808399293 230.88866308399292 -85.6853474278694 465.1518724278694 DOWN 0.125 0.875 0.0 GO:0045597 6 positive regulation of cell differentiation 285 303 8 8 6 6 5 5 33 298 2211 0.70584 0.47862 0.79941 1.65 89829;361921;170568;60628;24253 socs3;ect2;dmbt1;cxcr4;cebpb SOCS3_32863;ECT2_8523;DMBT1_32993;CXCR4_8411;CEBPB_32843,CEBPB_8282 24253(-0.009836) 292.76272600000027 31.2319 1.65461E-12 391.3183848158513 364.5055888678155 417.45806092918764 183.14901400000034 16.4725 1.65461E-12 244.45933588541538 225.84071494474227 257.45021222620124 740.5047560000003 67.1945 1.65462E-12 1049.76898144926 965.2867619555043 1161.2988069242367 809.124;31.2319;2.64673;1.65461E-12;620.8109999999999 488.627;16.4725;1.09657;1.65461E-12;409.549 2346.74;67.1945;8.73928;1.65462E-12;1279.85 2 4 2 89829;170568 SOCS3_32863;DMBT1_32993 405.88536500000004 405.88536500000004 570.2655464898143 244.861785 244.861785 344.73607308779344 1177.7396399999998 1177.7396399999998 1653.2161635310308 809.124;2.64673 488.627;1.09657 2346.74;8.73928 3 361921;60628;24253 ECT2_8523;CXCR4_8411;CEBPB_32843,CEBPB_8282 217.34763333333387 31.2319 349.75830808703165 142.00716666666722 16.4725 231.8443664434896 449.01483333333385 67.1945 720.308323452591 31.2319;1.65461E-12;620.8109999999999 16.4725;1.65461E-12;409.549 67.1945;1.65462E-12;1279.85 0 Exp 4,2(0.34);Hill,1(0.17);Linear,3(0.5) 1.7451601295060801 10.526552677154541 1.5669527053833008 2.1538212299346924 0.20633857648980874 1.7060840725898743 -50.242961643116246 635.7684136431169 -31.129041567502725 397.4270695675034 -179.65832685097416 1660.6678388509747 DOWN 0.4 0.6 0.0 GO:0070925 6 organelle assembly 79 80 6 6 3 4 2 2 36 78 2431 0.88507 0.33659 0.33659 2.5 362246;361308 tp53inp2;kif20a TP53INP2_32755;KIF20A_8961 431.26985 431.26985 35.2747 560.0217117639681 661.6601627162513 455.4831778013987 255.519 255.519 15.546 339.37307120335873 395.13549407437677 276.02273569899825 1297.57205 1297.57205 96.5441 1698.5100156791555 1996.3311256640786 1381.4513316496418 827.265;35.2747 495.492;15.546 2498.6;96.5441 0 2 0 2 362246;361308 TP53INP2_32755;KIF20A_8961 431.26985 431.26985 560.0217117639681 255.519 255.519 339.37307120335873 1297.57205 1297.57205 1698.5100156791555 827.265;35.2747 495.492;15.546 2498.6;96.5441 0 Exp 4,1(0.5);Linear,1(0.5) 1.6726848036157493 3.3515658378601074 1.5739303827285767 1.7776354551315308 0.1440412380582255 1.6757829189300537 -344.88064399999996 1207.4203440000001 -214.82807999999994 725.86608 -1056.4427319999998 3651.586832 DOWN 0.0 1.0 0.0 GO:0097327 5 response to antineoplastic agent 75 80 3 2 2 2 2 2 36 78 2431 0.88507 0.33659 0.33659 2.5 24587;25612 nefh;asns NEFH_33218;ASNS_8091 78.88250000000147 78.88250000000147 2.95157E-12 111.55670133389356 100.53631218988976 107.27125639140068 49.78315000000148 49.78315000000148 2.95157E-12 70.40400590765205 63.4489818425651 67.69943964277883 185.60950000000147 185.60950000000147 2.95158E-12 262.4914722052869 236.56063939922328 252.40787580489845 2.95157E-12;157.765 2.95157E-12;99.5663 2.95158E-12;371.219 1 1 1 25612 ASNS_8091 157.765 157.765 99.5663 99.5663 371.219 371.219 157.765 99.5663 371.219 1 24587 NEFH_33218 2.95157E-12 2.95157E-12 2.95157E-12 2.95157E-12 2.95158E-12 2.95158E-12 2.95157E-12 2.95157E-12 2.95158E-12 0 Hill,1(0.5);Poly 2,1(0.5) 1.9773317434199338 4.04377293586731 1.5997679233551025 2.444005012512207 0.5969657706721805 2.021886467933655 -75.7271999999956 233.49219999999855 -47.791823999995614 147.35812399999855 -178.18511999999563 549.4041199999986 CONFLICT 0.5 0.5 0.0 GO:0048523 5 negative regulation of cellular process 938 999 33 29 21 20 15 15 23 984 1525 0.58325 0.54916 1.0 1.5 24522;362246;360243;89829;299276;25106;363140;24314;316351;114519;24567;304477;83928;24253;25612 zfp354a;tp53inp2;top2a;socs3;serpina3m;rgn;rassf1;nqo1;npas2;nfil3;mt1;kntc1;fetub;cebpb;asns ZFP354A_10203;TP53INP2_32755;TOP2A_10059;SOCS3_32863;SERPINA3M_9809;RGN_9699;RASSF1_32475;NQO1_33055;NPAS2_9350;NFIL3_9304;MT1A_9255;KNTC1_8976;FETUB_33027;CEBPB_32843,CEBPB_8282;ASNS_8091 24253(-0.009836) 379.61408 168.588 12.3342 334.492051697923 390.59002493923674 343.5516464992543 241.90870933333335 103.554 3.46407 212.35635218212877 250.39660427974596 221.30440336225544 913.9597466666668 918.743 40.2833 838.5245616212211 895.6842417020417 811.5617997287258 99.2226;827.265;12.3342;809.124;466.86;752.835;903.848;40.5511;155.028;121.321;168.588;12.7573;545.901;620.8109999999999;157.765 71.0566;495.492;3.46407;488.627;296.126;458.716;608.514;21.5832;98.033;82.5516;103.554;9.63387;382.164;409.549;99.5663 163.536;2498.6;46.5267;2346.74;918.743;1994.77;1171.72;79.3552;382.695;229.79;1208.95;40.2833;976.618;1279.85;371.219 5 11 5 89829;363140;24314;83928;25612 SOCS3_32863;RASSF1_32475;NQO1_33055;FETUB_33027;ASNS_8091 491.43782 545.901 383.6043823346678 320.0909 382.164 251.58662401093594 989.1304399999999 976.618 878.3656358514762 809.124;903.848;40.5511;545.901;157.765 488.627;608.514;21.5832;382.164;99.5663 2346.74;1171.72;79.3552;976.618;371.219 10 24522;362246;360243;299276;25106;316351;114519;24567;304477;24253 ZFP354A_10203;TP53INP2_32755;TOP2A_10059;SERPINA3M_9809;RGN_9699;NPAS2_9350;NFIL3_9304;MT1A_9255;KNTC1_8976;CEBPB_32843,CEBPB_8282 323.70221 161.808 313.40347659825363 202.817614 100.7935 192.1533978690902 876.3744 650.719 863.7929057803522 99.2226;827.265;12.3342;466.86;752.835;155.028;121.321;168.588;12.7573;620.8109999999999 71.0566;495.492;3.46407;296.126;458.716;98.033;82.5516;103.554;9.63387;409.549 163.536;2498.6;46.5267;918.743;1994.77;382.695;229.79;1208.95;40.2833;1279.85 0 Exp 2,3(0.19);Exp 4,1(0.07);Exp 5,1(0.07);Hill,1(0.07);Linear,4(0.25);Poly 2,6(0.38) 1.8651836925360883 30.491414308547974 1.5054508447647095 2.846071243286133 0.4328960547712706 1.72762531042099 210.3377462997987 548.8904137002013 134.44156757953508 349.37585108713165 489.60776942747117 1338.3117239058624 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0051052 6 regulation of DNA metabolic process 84 88 4 4 4 2 2 2 36 86 2423 0.85825 0.38043 0.38043 2.27 25106;316351 rgn;npas2 RGN_9699;NPAS2_9350 453.9315 453.9315 155.028 422.7133835407865 334.1606646595139 387.2938143427861 278.3745 278.3745 98.033 255.04139515870747 206.11153853733302 233.67122639681216 1188.7325 1188.7325 382.695 1139.9091642813034 865.7527266257937 1044.3950568605699 752.835;155.028 458.716;98.033 1994.77;382.695 0 2 0 2 25106;316351 RGN_9699;NPAS2_9350 453.9315 453.9315 422.7133835407865 278.3745 278.3745 255.04139515870747 1188.7325 1188.7325 1139.9091642813034 752.835;155.028 458.716;98.033 1994.77;382.695 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.6372586517686014 3.2780280113220215 1.563178539276123 1.7148494720458984 0.10724754507039713 1.6390140056610107 -131.91935999999998 1039.7823600000002 -75.09483999999992 631.84384 -391.1010000000001 2768.5660000000003 DOWN 0.0 1.0 0.0 GO:0006565 9 L-serine catabolic process 1 1 1 1 1 1 1 1 37 0 2509 1.0 0.01492 0.01492 100.0 25044 sds SDS_9798 553.681 553.681 553.681 553.681 377.484 377.484 377.484 377.484 1035.66 1035.66 1035.66 1035.66 0.0 553.681 0.0 553.681 553.681 377.484 1035.66 1 0 1 25044 SDS_9798 553.681 553.681 377.484 377.484 1035.66 1035.66 553.681 377.484 1035.66 0 0 Linear,1(1) 1.5452189445495605 1.5452189445495605 1.5452189445495605 1.5452189445495605 0.0 1.5452189445495605 553.681 553.681 377.484 377.484 1035.66 1035.66 UP 1.0 0.0 0.0 GO:0034641 4 cellular nitrogen compound metabolic process 478 543 15 14 11 9 7 7 31 536 1973 0.41935 0.73086 0.84195 1.29 360243;114519;291885;24450;25612;25748;54223 top2a;nfil3;mcm5;hmgcs2;asns;alas2;adcy4 TOP2A_10059;NFIL3_9304;MCM5_9209;HMGCS2_8812;ASNS_8091;ALAS2_8019;ADCY4_7988 170.29927142857144 106.351 12.3342 246.90262135657665 173.40567121561054 237.15660465737196 98.0149142857143 59.8697 3.46407 135.13250137540587 99.58685839511676 129.84666836353045 444.6677571428571 208.329 36.0856 733.3862797645178 443.0834874278781 710.2548112458605 12.3342;121.321;12.5006;106.351;157.765;65.3911;716.432 3.46407;82.5516;9.67503;59.8697;99.5663;37.2697;393.708 46.5267;229.79;36.0856;208.329;371.219;133.644;2087.08 1 6 1 25612 ASNS_8091 157.765 157.765 99.5663 99.5663 371.219 371.219 157.765 99.5663 371.219 6 360243;114519;291885;24450;25748;54223 TOP2A_10059;NFIL3_9304;MCM5_9209;HMGCS2_8812;ALAS2_8019;ADCY4_7988 172.38831666666667 85.87105 270.4004933339466 97.75635 48.5697 148.02834163583054 456.9092166666667 170.9865 802.6006195073073 12.3342;121.321;12.5006;106.351;65.3911;716.432 3.46407;82.5516;9.67503;59.8697;37.2697;393.708 46.5267;229.79;36.0856;208.329;133.644;2087.08 0 Exp 2,1(0.15);Exp 4,1(0.15);Exp 5,2(0.29);Hill,1(0.15);Poly 2,2(0.29) 1.9985154529118954 14.323562264442444 1.5997679233551025 2.846071243286133 0.4957796554064419 1.7765510082244873 -12.608750136073638 353.2072929932165 -2.092643665082619 198.12247223651121 -98.63240199419442 987.9679162799086 DOWN 0.14285714285714285 0.8571428571428571 0.0 GO:0050793 4 regulation of developmental process 584 616 15 15 11 10 8 8 30 608 1901 0.40807 0.73406 0.84856 1.3 89829;25106;338475;499271;361921;170568;60628;24253 socs3;rgn;nrep;itgax;ect2;dmbt1;cxcr4;cebpb SOCS3_32863;RGN_9699;NREP_9364;ITGAX_32980;ECT2_8523;DMBT1_32993;CXCR4_8411;CEBPB_32843,CEBPB_8282 24253(-0.009836) 309.8913287500002 131.24099999999999 1.65461E-12 353.4726754652184 299.837966025852 341.5546548047815 193.5908212500002 87.13275 1.65461E-12 218.00205497991746 187.44269505499318 208.8185118200906 780.3134725000002 272.607 1.65462E-12 957.3602703409516 765.2519491309042 954.8298408626246 809.124;752.835;114.178;148.304;31.2319;2.64673;1.65461E-12;620.8109999999999 488.627;458.716;79.0815;95.184;16.4725;1.09657;1.65461E-12;409.549 2346.74;1994.77;204.229;340.985;67.1945;8.73928;1.65462E-12;1279.85 2 7 2 89829;170568 SOCS3_32863;DMBT1_32993 405.88536500000004 405.88536500000004 570.2655464898143 244.861785 244.861785 344.73607308779344 1177.7396399999998 1177.7396399999998 1653.2161635310308 809.124;2.64673 488.627;1.09657 2346.74;8.73928 6 25106;338475;499271;361921;60628;24253 RGN_9699;NREP_9364;ITGAX_32980;ECT2_8523;CXCR4_8411;CEBPB_32843,CEBPB_8282 277.893316666667 131.24099999999999 323.9829581739161 176.50050000000024 87.13275 203.38211023096375 647.8380833333337 272.607 807.6451742682805 752.835;114.178;148.304;31.2319;1.65461E-12;620.8109999999999 458.716;79.0815;95.184;16.4725;1.65461E-12;409.549 1994.77;204.229;340.985;67.1945;1.65462E-12;1279.85 0 Exp 2,1(0.12);Exp 4,2(0.23);Hill,1(0.12);Linear,3(0.34);Poly 2,2(0.23) 1.7465934311415643 15.780848979949951 1.5669527053833008 2.1538212299346924 0.17100546365538646 1.7148494720458984 64.94726148010463 554.8353960198957 42.52310448887613 344.65853801112434 116.89665208726046 1443.73029291274 DOWN 0.25 0.75 0.0 GO:0045786 6 negative regulation of cell cycle 105 115 12 10 8 4 3 3 35 112 2397 0.91048 0.24445 0.24445 2.61 360243;363140;304477 top2a;rassf1;kntc1 TOP2A_10059;RASSF1_32475;KNTC1_8976 309.6465 12.7573 12.3342 514.5936374510377 416.150921420326 543.3813432376346 207.20398 9.63387 3.46407 347.5583630446983 279.0550095165535 367.08654095415204 419.51 46.5267 40.2833 651.4404486105311 554.4275110218405 687.7794527722847 12.3342;903.848;12.7573 3.46407;608.514;9.63387 46.5267;1171.72;40.2833 1 2 1 363140 RASSF1_32475 903.848 903.848 608.514 608.514 1171.72 1171.72 903.848 608.514 1171.72 2 360243;304477 TOP2A_10059;KNTC1_8976 12.54575 12.54575 0.2991768791200032 6.54897 6.54897 4.362707418564761 43.405 43.405 4.414750477659989 12.3342;12.7573 3.46407;9.63387 46.5267;40.2833 0 Exp 5,1(0.34);Hill,1(0.34);Poly 2,1(0.34) 2.3938035808602 7.316149711608887 1.8158698081970215 2.846071243286133 0.5478652934085463 2.6542086601257324 -272.67101920702567 891.9640192070256 -186.09533234740604 600.503292347406 -317.66426399794943 1156.6842639979495 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0009615 5 response to virus 66 68 4 3 3 3 3 3 35 65 2444 0.98267 0.079068 0.079068 4.41 363328;499271;24296 ticam1;itgax;cyp1a1 TICAM1_10015;ITGAX_32980;CYP1A1_8415 336.1569666666667 148.304 49.0449 414.3150122795496 233.30913052940403 350.73825644263053 207.93643333333333 95.184 39.2363 245.3450564944469 147.0819144064457 207.5467026470366 922.9026333333333 340.985 64.8529 1254.6679827593048 611.8776862065946 1060.856020769476 811.122;148.304;49.0449 489.389;95.184;39.2363 2362.87;340.985;64.8529 1 2 1 24296 CYP1A1_8415 49.0449 49.0449 39.2363 39.2363 64.8529 64.8529 49.0449 39.2363 64.8529 2 363328;499271 TICAM1_10015;ITGAX_32980 479.71299999999997 479.71299999999997 468.68310249250504 292.2865 292.2865 278.745028677643 1351.9275 1351.9275 1429.6885942793622 811.122;148.304 489.389;95.184 2362.87;340.985 0 Linear,1(0.34);Poly 2,2(0.67) 2.9393743399303114 12.231341004371643 1.5415632724761963 8.822484970092773 4.112838012883158 1.8672927618026733 -132.6846057163794 804.9985390497127 -69.69763411303589 485.57050077970257 -496.88784594245794 2342.693112609125 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0009966 5 regulation of signal transduction 594 626 11 9 6 7 5 5 33 621 1888 0.066205 0.974 0.12756 0.8 363328;89829;25106;338475;60628 ticam1;socs3;rgn;nrep;cxcr4 TICAM1_10015;SOCS3_32863;RGN_9699;NREP_9364;CXCR4_8411 497.4518000000004 752.835 1.65461E-12 404.69316542066736 507.1590964508852 394.39918053929966 303.1627000000003 458.716 1.65461E-12 242.58713763913735 309.7326655241237 234.68798716009076 1381.7218000000003 1994.77 1.65462E-12 1179.5533517888027 1412.145141617494 1178.697256363888 811.122;809.124;752.835;114.178;1.65461E-12 489.389;488.627;458.716;79.0815;1.65461E-12 2362.87;2346.74;1994.77;204.229;1.65462E-12 1 4 1 89829 SOCS3_32863 809.124 809.124 488.627 488.627 2346.74 2346.74 809.124 488.627 2346.74 4 363328;25106;338475;60628 TICAM1_10015;RGN_9699;NREP_9364;CXCR4_8411 419.5337500000004 433.5065 421.7747353887493 256.7966250000004 268.89875 253.24416358769042 1140.4672500000004 1099.4995 1211.2403120975823 811.122;752.835;114.178;1.65461E-12 489.389;458.716;79.0815;1.65461E-12 2362.87;1994.77;204.229;1.65462E-12 0 Exp 2,1(0.2);Hill,1(0.2);Linear,2(0.4);Poly 2,1(0.2) 1.6809538943482802 8.413447976112366 1.5415632724761963 1.744480013847351 0.0839800172850749 1.7148494720458984 142.72260025921003 852.1809997407906 90.52569855054247 515.7997014494583 347.79770074650605 2415.6458992534945 DOWN 0.2 0.8 0.0 GO:0032103 6 positive regulation of response to external stimulus 125 131 4 4 4 3 3 3 35 128 2381 0.87167 0.3104 0.44284 2.29 363328;60628;24253 ticam1;cxcr4;cebpb TICAM1_10015;CXCR4_8411;CEBPB_32843,CEBPB_8282 24253(-0.009836) 477.31100000000055 620.8109999999999 1.65461E-12 424.17438892629895 556.4363914580549 389.1393843103806 299.6460000000006 409.549 1.65461E-12 262.5536143095339 347.7950757691577 238.63362839445315 1214.2400000000005 1279.85 1.65462E-12 1182.8005593928328 1438.5603162621826 1130.1144970880493 811.122;1.65461E-12;620.8109999999999 489.389;1.65461E-12;409.549 2362.87;1.65462E-12;1279.85 0 4 0 3 363328;60628;24253 TICAM1_10015;CXCR4_8411;CEBPB_32843,CEBPB_8282 477.31100000000055 620.8109999999999 424.17438892629895 299.6460000000006 409.549 262.5536143095339 1214.2400000000005 1279.85 1182.8005593928328 811.122;1.65461E-12;620.8109999999999 489.389;1.65461E-12;409.549 2362.87;1.65462E-12;1279.85 0 Hill,1(0.25);Linear,3(0.75) 1.6291637838156379 6.524762988090515 1.5415632724761963 1.744480013847351 0.09423463654997866 1.6193598508834839 -2.68750735468916 957.3095073546903 2.5386161992960297 596.753383800705 -124.22483387165971 2552.7048338716604 DOWN 0.0 1.0 0.0 GO:0044283 4 small molecule biosynthetic process 144 161 10 10 8 9 8 8 30 153 2356 0.99957 0.0020469 0.0020469 4.97 25044;25106;24450;60671;266674;29277;24296;25612 sds;rgn;hmgcs2;gulo;cyp4a8;cyp2c11;cyp1a1;asns SDS_9798;RGN_9699;HMGCS2_8812;GULO_8772;CYP4A8_32747;CYP2C11_32593;CYP1A1_8415;ASNS_8091 263.3834375 175.877 49.0449 252.82632083745858 199.64132343674783 220.51683183879246 168.0656125 105.92015 39.2363 159.1986091252185 127.55483250601763 139.77810317566679 649.5608625 370.0815 64.8529 664.5926080331855 468.9047540224659 576.7821882668692 553.681;752.835;106.351;193.989;76.6586;216.743;49.0449;157.765 377.484;458.716;59.8697;112.274;57.8156;139.563;39.2363;99.5663 1035.66;1994.77;208.329;1039.83;112.882;368.944;64.8529;371.219 5 3 5 25044;60671;266674;24296;25612 SDS_9798;GULO_8772;CYP4A8_32747;CYP1A1_8415;ASNS_8091 206.2277 157.765 202.92658711989915 137.27524 99.5663 137.5433955915841 524.88878 371.219 482.45432378981945 553.681;193.989;76.6586;49.0449;157.765 377.484;112.274;57.8156;39.2363;99.5663 1035.66;1039.83;112.882;64.8529;371.219 3 25106;24450;29277 RGN_9699;HMGCS2_8812;CYP2C11_32593 358.64300000000003 216.743 345.8136753571206 219.38289999999998 139.563 211.06398338638928 857.3476666666667 368.944 988.3048455969106 752.835;106.351;216.743 458.716;59.8697;139.563 1994.77;208.329;368.944 0 Exp 2,2(0.25);Exp 4,1(0.13);Linear,1(0.13);Poly 2,4(0.5) 2.587489932713364 27.77273154258728 1.5452189445495605 8.822484970092773 3.1785431119591188 1.6573086977005005 88.18373569191957 438.5831393080805 57.74660475344962 278.38462024655047 189.02168143061573 1110.1000435693843 UP 0.625 0.375 0.0 GO:2000026 5 regulation of multicellular organismal development 487 514 13 13 9 9 7 7 31 507 2002 0.4886 0.67128 1.0 1.36 25106;338475;499271;361921;170568;60628;24253 rgn;nrep;itgax;ect2;dmbt1;cxcr4;cebpb RGN_9699;NREP_9364;ITGAX_32980;ECT2_8523;DMBT1_32993;CXCR4_8411;CEBPB_32843,CEBPB_8282 24253(-0.009836) 238.57237571428595 114.178 1.65461E-12 313.5183446588078 197.89908246761672 265.01868607068366 151.44279571428595 79.0815 1.65461E-12 197.1432358552838 127.15753162379733 167.3330597715544 556.5382542857145 204.229 1.65462E-12 775.8383966745731 448.70070776215164 644.994041981349 752.835;114.178;148.304;31.2319;2.64673;1.65461E-12;620.8109999999999 458.716;79.0815;95.184;16.4725;1.09657;1.65461E-12;409.549 1994.77;204.229;340.985;67.1945;8.73928;1.65462E-12;1279.85 1 7 1 170568 DMBT1_32993 2.64673 2.64673 1.09657 1.09657 8.73928 8.73928 2.64673 1.09657 8.73928 6 25106;338475;499271;361921;60628;24253 RGN_9699;NREP_9364;ITGAX_32980;ECT2_8523;CXCR4_8411;CEBPB_32843,CEBPB_8282 277.893316666667 131.24099999999999 323.9829581739161 176.50050000000024 87.13275 203.38211023096375 647.8380833333337 272.607 807.6451742682805 752.835;114.178;148.304;31.2319;1.65461E-12;620.8109999999999 458.716;79.0815;95.184;16.4725;1.65461E-12;409.549 1994.77;204.229;340.985;67.1945;1.65462E-12;1279.85 0 Exp 2,1(0.13);Exp 4,2(0.25);Hill,1(0.13);Linear,2(0.25);Poly 2,2(0.25) 1.7473690139484828 14.04044783115387 1.5669527053833008 2.1538212299346924 0.18273792609184233 1.6935017704963684 6.31473571561051 470.8300157129613 5.3970427894287525 297.4885486391431 -18.210873163565907 1131.287381734995 DOWN 0.14285714285714285 0.8571428571428571 0.0 GO:2000145 5 regulation of cell motility 264 277 4 4 3 4 3 3 35 274 2235 0.39408 0.79943 0.79251 1.08 25106;499271;60628 rgn;itgax;cxcr4 RGN_9699;ITGAX_32980;CXCR4_8411 300.3796666666672 148.304 1.65461E-12 398.7924154247832 242.9101679350215 319.7690615251972 184.6333333333339 95.184 1.65461E-12 242.0867191510782 151.00379423386534 193.52890235644264 778.5850000000005 340.985 1.65462E-12 1066.9569617491602 611.3455392946 862.0479135318216 752.835;148.304;1.65461E-12 458.716;95.184;1.65461E-12 1994.77;340.985;1.65462E-12 0 3 0 3 25106;499271;60628 RGN_9699;ITGAX_32980;CXCR4_8411 300.3796666666672 148.304 398.7924154247832 184.6333333333339 95.184 242.0867191510782 778.5850000000005 340.985 1066.9569617491602 752.835;148.304;1.65461E-12 458.716;95.184;1.65461E-12 1994.77;340.985;1.65462E-12 0 Exp 2,1(0.34);Hill,1(0.34);Poly 2,1(0.34) 1.7743316741284039 5.326622247695923 1.7148494720458984 1.8672927618026733 0.0808289311443755 1.744480013847351 -150.89643379004087 751.6557671233753 -89.31357830611847 458.58024497278626 -428.7904625960605 1985.9604625960615 DOWN 0.0 1.0 0.0 GO:2000431 6 regulation of cytokinesis, actomyosin contractile ring assembly 1 1 1 1 1 1 1 1 37 0 2509 1.0 0.01492 0.01492 100.0 361921 ect2 ECT2_8523 31.2319 31.2319 31.2319 31.2319 16.4725 16.4725 16.4725 16.4725 67.1945 67.1945 67.1945 67.1945 0.0 31.2319 0.0 31.2319 31.2319 16.4725 67.1945 0 1 0 1 361921 ECT2_8523 31.2319 31.2319 16.4725 16.4725 67.1945 67.1945 31.2319 16.4725 67.1945 0 Exp 4,1(1) 2.1538212299346924 2.1538212299346924 2.1538212299346924 2.1538212299346924 0.0 2.1538212299346924 31.2319 31.2319 16.4725 16.4725 67.1945 67.1945 DOWN 0.0 1.0 0.0 GO:0051172 6 negative regulation of nitrogen compound metabolic process 471 499 18 16 11 11 7 7 31 492 2017 0.52546 0.63781 1.0 1.4 24522;89829;299276;25106;114519;83928;24253 zfp354a;socs3;serpina3m;rgn;nfil3;fetub;cebpb ZFP354A_10203;SOCS3_32863;SERPINA3M_9809;RGN_9699;NFIL3_9304;FETUB_33027;CEBPB_32843,CEBPB_8282 24253(-0.009836) 488.01065714285716 545.901 99.2226 282.9304221652788 486.2383471024697 268.1325383732967 312.68431428571427 382.164 71.0566 172.29358288583498 312.0927307679809 163.41760902532127 1130.0067142857142 976.618 163.536 822.9342488977505 1112.2728755686742 800.7195225519321 99.2226;809.124;466.86;752.835;121.321;545.901;620.8109999999999 71.0566;488.627;296.126;458.716;82.5516;382.164;409.549 163.536;2346.74;918.743;1994.77;229.79;976.618;1279.85 2 6 2 89829;83928 SOCS3_32863;FETUB_33027 677.5125 677.5125 186.12676826426633 435.39549999999997 435.39549999999997 75.28070924546384 1661.6789999999999 1661.6789999999999 968.8225572528748 809.124;545.901 488.627;382.164 2346.74;976.618 5 24522;299276;25106;114519;24253 ZFP354A_10203;SERPINA3M_9809;RGN_9699;NFIL3_9304;CEBPB_32843,CEBPB_8282 412.20991999999995 466.86 293.7277281794009 263.59984 296.126 180.47215073176247 917.3378 918.743 763.7434690884104 99.2226;466.86;752.835;121.321;620.8109999999999 71.0566;296.126;458.716;82.5516;409.549 163.536;918.743;1994.77;229.79;1279.85 0 Exp 2,3(0.38);Linear,3(0.38);Poly 2,2(0.25) 1.7139757349144589 13.790323138237 1.5054508447647095 2.1583378314971924 0.2041672557859616 1.6933082342147827 278.41286723538076 697.6084470503336 185.0474418994145 440.32118667201416 520.3684912621845 1739.644937309244 DOWN 0.2857142857142857 0.7142857142857143 0.0 GO:0045893 8 positive regulation of transcription, DNA-templated 299 321 9 9 6 8 5 5 33 316 2193 0.65622 0.53248 0.80803 1.56 362246;360243;316351;114519;24253 tp53inp2;top2a;npas2;nfil3;cebpb TP53INP2_32755;TOP2A_10059;NPAS2_9350;NFIL3_9304;CEBPB_32843,CEBPB_8282 24253(-0.009836) 347.35184 155.028 12.3342 355.461591632525 310.27324404695753 351.6039460374267 217.817934 98.033 3.46407 219.34942394350108 193.1930222026952 214.93859765543263 887.49234 382.695 46.5267 1017.8688957381142 813.392375854404 1029.6562683421782 827.265;12.3342;155.028;121.321;620.8109999999999 495.492;3.46407;98.033;82.5516;409.549 2498.6;46.5267;382.695;229.79;1279.85 0 6 0 5 362246;360243;316351;114519;24253 TP53INP2_32755;TOP2A_10059;NPAS2_9350;NFIL3_9304;CEBPB_32843,CEBPB_8282 347.35184 155.028 355.461591632525 217.817934 98.033 219.34942394350108 887.49234 382.695 1017.8688957381142 827.265;12.3342;155.028;121.321;620.8109999999999 495.492;3.46407;98.033;82.5516;409.549 2498.6;46.5267;382.695;229.79;1279.85 0 Hill,1(0.17);Linear,3(0.5);Poly 2,2(0.34) 1.8461422218276768 11.380237698554993 1.563178539276123 2.846071243286133 0.5185566578942313 1.6228486895561218 35.7760173460062 658.9276626539938 25.5496866768693 410.08618132313063 -4.709084876803104 1779.693764876803 DOWN 0.0 1.0 0.0 GO:1901698 4 response to nitrogen compound 416 438 16 14 12 13 10 10 28 428 2081 0.95064 0.10328 0.13256 2.28 24522;363328;89829;25044;24314;24587;24450;60628;24253;25612 zfp354a;ticam1;socs3;sds;nqo1;nefh;hmgcs2;cxcr4;cebpb;asns ZFP354A_10203;TICAM1_10015;SOCS3_32863;SDS_9798;NQO1_33055;NEFH_33218;HMGCS2_8812;CXCR4_8411;CEBPB_32843,CEBPB_8282;ASNS_8091 24253(-0.009836) 319.8627700000004 132.058 1.65461E-12 338.154702254134 323.06592875438065 340.45126606008756 201.71248000000045 85.31145000000001 1.65461E-12 210.9807653763395 200.53963115004805 211.20093272195007 784.7559200000004 289.774 1.65462E-12 934.3315003023146 816.3260273590319 967.5686158021646 99.2226;811.122;809.124;553.681;40.5511;2.95157E-12;106.351;1.65461E-12;620.8109999999999;157.765 71.0566;489.389;488.627;377.484;21.5832;2.95157E-12;59.8697;1.65461E-12;409.549;99.5663 163.536;2362.87;2346.74;1035.66;79.3552;2.95158E-12;208.329;1.65462E-12;1279.85;371.219 4 7 4 89829;25044;24314;25612 SOCS3_32863;SDS_9798;NQO1_33055;ASNS_8091 390.280275 355.723 355.2012161469925 246.815125 238.52515 222.08029650546632 958.2435499999999 703.4395000000001 1008.4572792904402 809.124;553.681;40.5511;157.765 488.627;377.484;21.5832;99.5663 2346.74;1035.66;79.3552;371.219 6 24522;363328;24587;24450;60628;24253 ZFP354A_10203;TICAM1_10015;NEFH_33218;HMGCS2_8812;CXCR4_8411;CEBPB_32843,CEBPB_8282 272.91776666666743 102.7868 351.4473536627729 171.6440500000008 65.46315 218.67570450383067 669.0975000000008 185.9325 959.7048366971475 99.2226;811.122;2.95157E-12;106.351;1.65461E-12;620.8109999999999 71.0566;489.389;2.95157E-12;59.8697;1.65461E-12;409.549 163.536;2362.87;2.95158E-12;208.329;1.65462E-12;1279.85 0 Exp 4,2(0.19);Hill,2(0.19);Linear,5(0.46);Poly 2,2(0.19) 1.8566063312215009 20.84608507156372 1.5415632724761963 2.5798087120056152 0.4218785046664099 1.7404011487960815 110.27231411864958 529.4532258813515 70.94524682933485 332.4797131706661 205.65125640286783 1363.8605835971327 DOWN 0.4 0.6 0.0 GO:0051607 5 defense response to virus 45 46 3 2 2 2 2 2 36 44 2465 0.97008 0.14917 0.14917 4.35 363328;499271 ticam1;itgax TICAM1_10015;ITGAX_32980 479.71299999999997 479.71299999999997 148.304 468.68310249250504 375.0980715946071 444.71933179418795 292.2865 292.2865 95.184 278.745028677643 230.06771920037193 264.4927931799195 1351.9275 1351.9275 340.985 1429.6885942793622 1032.806180846118 1356.5886052652336 811.122;148.304 489.389;95.184 2362.87;340.985 0 2 0 2 363328;499271 TICAM1_10015;ITGAX_32980 479.71299999999997 479.71299999999997 468.68310249250504 292.2865 292.2865 278.745028677643 1351.9275 1351.9275 1429.6885942793622 811.122;148.304 489.389;95.184 2362.87;340.985 0 Linear,1(0.5);Poly 2,1(0.5) 1.696628993196699 3.4088560342788696 1.5415632724761963 1.8672927618026733 0.23032553073518308 1.7044280171394348 -169.84863999999993 1129.2746399999999 -94.03440000000006 678.6074000000001 -629.5197999999993 3333.3747999999996 DOWN 0.0 1.0 0.0 GO:0006139 4 nucleobase-containing compound metabolic process 359 401 11 10 8 6 5 5 33 396 2113 0.43367 0.73743 0.82372 1.25 360243;114519;291885;24450;54223 top2a;nfil3;mcm5;hmgcs2;adcy4 TOP2A_10059;NFIL3_9304;MCM5_9209;HMGCS2_8812;ADCY4_7988 193.78776 106.351 12.3342 296.5822182493887 201.88096349592928 283.03280103923237 109.85368000000001 59.8697 3.46407 162.15084631555567 114.52668852793822 154.72030568201305 521.5622599999999 208.329 36.0856 879.6928855856047 529.1327767309164 848.7600241739417 12.3342;121.321;12.5006;106.351;716.432 3.46407;82.5516;9.67503;59.8697;393.708 46.5267;229.79;36.0856;208.329;2087.08 0 5 0 5 360243;114519;291885;24450;54223 TOP2A_10059;NFIL3_9304;MCM5_9209;HMGCS2_8812;ADCY4_7988 193.78776 106.351 296.5822182493887 109.85368000000001 59.8697 162.15084631555567 521.5622599999999 208.329 879.6928855856047 12.3342;121.321;12.5006;106.351;716.432 3.46407;82.5516;9.67503;59.8697;393.708 46.5267;229.79;36.0856;208.329;2087.08 0 Exp 2,1(0.2);Exp 4,1(0.2);Exp 5,1(0.2);Hill,1(0.2);Poly 2,1(0.2) 2.1548482144211336 11.010578155517578 1.6510682106018066 2.846071243286133 0.5106507035657912 2.1583378314971924 -66.17801636193815 453.75353636193813 -32.277803468515856 251.98516346851585 -249.52255186500406 1292.647071865004 DOWN 0.0 1.0 0.0 GO:0007576 8 nucleolar fragmentation 1 1 1 1 1 1 1 1 37 0 2509 1.0 0.01492 0.01492 100.0 24522 zfp354a ZFP354A_10203 99.2226 99.2226 99.2226 99.2226 71.0566 71.0566 71.0566 71.0566 163.536 163.536 163.536 163.536 0.0 99.2226 0.0 99.2226 99.2226 71.0566 163.536 0 1 0 1 24522 ZFP354A_10203 99.2226 99.2226 71.0566 71.0566 163.536 163.536 99.2226 71.0566 163.536 0 Poly 2,1(1) 1.8335704803466797 1.8335704803466797 1.8335704803466797 1.8335704803466797 0.0 1.8335704803466797 99.2226 99.2226 71.0566 71.0566 163.536 163.536 DOWN 0.0 1.0 0.0 GO:0031331 7 positive regulation of cellular catabolic process 107 115 7 7 5 6 4 4 34 111 2398 0.9738 0.089516 0.089516 3.48 360772;362246;363328;25106 zfand2a;tp53inp2;ticam1;rgn ZFAND2A_10197;TP53INP2_32755;TICAM1_10015;RGN_9699 834.31475 819.1935 752.835 81.05227414607177 853.5434369328032 81.05612922711948 532.8035 492.44050000000004 458.716 104.4559624610616 554.1738147751606 111.221995027218 2037.08 2178.8199999999997 1292.08 540.3563548252208 1988.3646074232688 603.4826211023027 946.037;827.265;811.122;752.835 687.617;495.492;489.389;458.716 1292.08;2498.6;2362.87;1994.77 1 3 1 360772 ZFAND2A_10197 946.037 946.037 687.617 687.617 1292.08 1292.08 946.037 687.617 1292.08 3 362246;363328;25106 TP53INP2_32755;TICAM1_10015;RGN_9699 797.074 811.122 39.15310911026402 481.199 489.389 19.708516407889384 2285.4133333333334 2362.87 260.69295854190955 827.265;811.122;752.835 495.492;489.389;458.716 2498.6;2362.87;1994.77 0 Exp 2,1(0.25);Linear,2(0.5);Poly 2,1(0.25) 1.8055171622788042 7.38441789150238 1.5415632724761963 2.554074764251709 0.47793789233959655 1.6443899273872375 754.8835213368495 913.7459786631505 430.43665678815984 635.1703432118401 1507.5307722712837 2566.629227728716 DOWN 0.25 0.75 0.0 GO:0006529 7 asparagine biosynthetic process 1 1 1 1 1 1 1 1 37 0 2509 1.0 0.01492 0.01492 100.0 25612 asns ASNS_8091 157.765 157.765 157.765 157.765 99.5663 99.5663 99.5663 99.5663 371.219 371.219 371.219 371.219 0.0 157.765 0.0 157.765 157.765 99.5663 371.219 1 0 1 25612 ASNS_8091 157.765 157.765 99.5663 99.5663 371.219 371.219 157.765 99.5663 371.219 0 0 Poly 2,1(1) 1.5997679233551025 1.5997679233551025 1.5997679233551025 1.5997679233551025 0.0 1.5997679233551025 157.765 157.765 99.5663 99.5663 371.219 371.219 UP 1.0 0.0 0.0 GO:0070981 7 L-asparagine biosynthetic process 1 1 1 1 1 1 1 1 37 0 2509 1.0 0.01492 0.01492 100.0 25612 asns ASNS_8091 157.765 157.765 157.765 157.765 99.5663 99.5663 99.5663 99.5663 371.219 371.219 371.219 371.219 0.0 157.765 0.0 157.765 157.765 99.5663 371.219 1 0 1 25612 ASNS_8091 157.765 157.765 99.5663 99.5663 371.219 371.219 157.765 99.5663 371.219 0 0 Poly 2,1(1) 1.5997679233551025 1.5997679233551025 1.5997679233551025 1.5997679233551025 0.0 1.5997679233551025 157.765 157.765 99.5663 99.5663 371.219 371.219 UP 1.0 0.0 0.0 GO:0070982 7 L-asparagine metabolic process 1 1 1 1 1 1 1 1 37 0 2509 1.0 0.01492 0.01492 100.0 25612 asns ASNS_8091 157.765 157.765 157.765 157.765 99.5663 99.5663 99.5663 99.5663 371.219 371.219 371.219 371.219 0.0 157.765 0.0 157.765 157.765 99.5663 371.219 1 0 1 25612 ASNS_8091 157.765 157.765 99.5663 99.5663 371.219 371.219 157.765 99.5663 371.219 0 0 Poly 2,1(1) 1.5997679233551025 1.5997679233551025 1.5997679233551025 1.5997679233551025 0.0 1.5997679233551025 157.765 157.765 99.5663 99.5663 371.219 371.219 UP 1.0 0.0 0.0 GO:0007568 3 aging 181 193 6 6 6 5 5 5 33 188 2321 0.93695 0.15613 0.20507 2.59 360243;89829;25106;24314;24296 top2a;socs3;rgn;nqo1;cyp1a1 TOP2A_10059;SOCS3_32863;RGN_9699;NQO1_33055;CYP1A1_8415 332.77784 49.0449 12.3342 409.85932252497685 248.95419262449772 380.303494501786 202.325314 39.2363 3.46407 248.2520754696232 152.17479020333616 229.44009001515394 906.44896 79.3552 46.5267 1160.8956967890065 676.2646029374164 1098.4373396479527 12.3342;809.124;752.835;40.5511;49.0449 3.46407;488.627;458.716;21.5832;39.2363 46.5267;2346.74;1994.77;79.3552;64.8529 3 2 3 89829;24314;24296 SOCS3_32863;NQO1_33055;CYP1A1_8415 299.5733333333333 49.0449 441.3042573836597 183.14883333333333 39.2363 264.6990568880504 830.3160333333332 79.3552 1313.281696433451 809.124;40.5511;49.0449 488.627;21.5832;39.2363 2346.74;79.3552;64.8529 2 360243;25106 TOP2A_10059;RGN_9699 382.5846 382.5846 523.6131371540635 231.090035 231.090035 321.91172685126344 1020.6483499999999 1020.6483499999999 1377.6160488312573 12.3342;752.835 3.46407;458.716 46.5267;1994.77 0 Exp 2,1(0.2);Exp 4,1(0.2);Hill,1(0.2);Linear,1(0.2);Poly 2,1(0.2) 2.865892612381696 17.7036155462265 1.7148494720458984 8.822484970092773 2.9949073336541447 2.5798087120056152 -26.479696100120748 692.0353761001209 -15.27722439175028 419.9278523917503 -111.12098358042351 1924.0189035804233 UP 0.6 0.4 0.0 GO:0031401 8 positive regulation of protein modification process 319 340 10 9 6 7 4 4 34 336 2173 0.41314 0.76718 0.81048 1.18 363328;363140;361921;60628 ticam1;rassf1;ect2;cxcr4 TICAM1_10015;RASSF1_32475;ECT2_8523;CXCR4_8411 436.5504750000004 421.17695 1.65461E-12 487.69193441307664 693.6897474725032 408.7476761702327 278.5938750000004 252.93075000000002 1.65461E-12 316.01900576979364 452.7781230974338 271.9973009058067 900.4461250000004 619.45725 1.65462E-12 1113.1613539854534 1222.949260637707 910.8579529656383 811.122;903.848;31.2319;1.65461E-12 489.389;608.514;16.4725;1.65461E-12 2362.87;1171.72;67.1945;1.65462E-12 1 3 1 363140 RASSF1_32475 903.848 903.848 608.514 608.514 1171.72 1171.72 903.848 608.514 1171.72 3 363328;361921;60628 TICAM1_10015;ECT2_8523;CXCR4_8411 280.7846333333339 31.2319 459.55103063381637 168.62050000000056 16.4725 277.9157403931086 810.0215000000004 67.1945 1345.2258632555904 811.122;31.2319;1.65461E-12 489.389;16.4725;1.65461E-12 2362.87;67.1945;1.65462E-12 0 Exp 4,1(0.25);Hill,1(0.25);Linear,1(0.25);Poly 2,1(0.25) 1.9801268697332395 8.094073176383972 1.5415632724761963 2.6542086601257324 0.49155949032969526 1.9491506218910217 -41.387620724814724 914.4885707248154 -31.104750654397378 588.292500654398 -190.45200190574383 1991.344251905745 DOWN 0.25 0.75 0.0 GO:0046394 6 carboxylic acid biosynthetic process 88 95 8 8 7 8 7 7 31 88 2421 0.99995 3.935E-4 3.935E-4 7.37 25044;25106;60671;266674;29277;24296;25612 sds;rgn;gulo;cyp4a8;cyp2c11;cyp1a1;asns SDS_9798;RGN_9699;GULO_8772;CYP4A8_32747;CYP2C11_32593;CYP1A1_8415;ASNS_8091 285.8166428571429 193.989 49.0449 264.3438771159255 229.70656081974755 247.61248220482943 183.52217142857145 112.274 39.2363 165.34342444980697 149.36812997489127 155.2259921461408 712.5939857142857 371.219 64.8529 691.5303757761005 552.8820799908053 644.4370186756134 3.5 205.36599999999999 553.681;752.835;193.989;76.6586;216.743;49.0449;157.765 377.484;458.716;112.274;57.8156;139.563;39.2363;99.5663 1035.66;1994.77;1039.83;112.882;368.944;64.8529;371.219 5 2 5 25044;60671;266674;24296;25612 SDS_9798;GULO_8772;CYP4A8_32747;CYP1A1_8415;ASNS_8091 206.2277 157.765 202.92658711989915 137.27524 99.5663 137.5433955915841 524.88878 371.219 482.45432378981945 553.681;193.989;76.6586;49.0449;157.765 377.484;112.274;57.8156;39.2363;99.5663 1035.66;1039.83;112.882;64.8529;371.219 2 25106;29277 RGN_9699;CYP2C11_32593 484.789 484.789 379.07428853985874 299.1395 299.1395 225.67525053603023 1181.857 1181.857 1149.6325896293997 752.835;216.743 458.716;139.563 1994.77;368.944 0 Exp 2,2(0.29);Linear,1(0.15);Poly 2,4(0.58) 2.588769613473063 25.19418168067932 1.5452189445495605 8.822484970092773 3.411023772070992 1.5997679233551025 89.98795821076288 481.6453275035229 61.03404846465533 306.01029439248754 200.3011141761158 1224.8868572524557 UP 0.7142857142857143 0.2857142857142857 0.0 GO:1901701 5 cellular response to oxygen-containing compound 359 378 16 13 10 10 7 7 31 371 2138 0.80818 0.33021 0.49255 1.85 363328;24314;24587;24567;24450;361921;24253 ticam1;nqo1;nefh;mt1;hmgcs2;ect2;cebpb TICAM1_10015;NQO1_33055;NEFH_33218;MT1A_9255;HMGCS2_8812;ECT2_8523;CEBPB_32843,CEBPB_8282 24253(-0.009836) 254.09357142857183 106.351 2.95157E-12 324.99555575154477 234.61188013514302 298.6102259418042 157.20248571428615 59.8697 2.95157E-12 203.83351694921993 143.66978189028254 186.93270107575884 743.7926714285719 208.329 2.95158E-12 900.4028095101223 721.8646939872875 856.7851203272221 811.122;40.5511;2.95157E-12;168.588;106.351;31.2319;620.8109999999999 489.389;21.5832;2.95157E-12;103.554;59.8697;16.4725;409.549 2362.87;79.3552;2.95158E-12;1208.95;208.329;67.1945;1279.85 1 7 1 24314 NQO1_33055 40.5511 40.5511 21.5832 21.5832 79.3552 79.3552 40.5511 21.5832 79.3552 6 363328;24587;24567;24450;361921;24253 TICAM1_10015;NEFH_33218;MT1A_9255;HMGCS2_8812;ECT2_8523;CEBPB_32843,CEBPB_8282 289.6839833333338 137.46949999999998 340.7439554646294 179.80570000000048 81.71185 213.46221837008952 854.5322500000005 708.6395 932.6622794163886 811.122;2.95157E-12;168.588;106.351;31.2319;620.8109999999999 489.389;2.95157E-12;103.554;59.8697;16.4725;409.549 2362.87;2.95158E-12;1208.95;208.329;67.1945;1279.85 0 Exp 4,3(0.38);Hill,1(0.13);Linear,3(0.38);Poly 2,1(0.13) 2.0335694359420526 16.604723691940308 1.5415632724761963 2.5798087120056152 0.4401425303961261 2.111038565635681 13.333494467023712 494.85364839012004 6.200503196240703 308.2044682323316 76.76493557923084 1410.820407277913 DOWN 0.14285714285714285 0.8571428571428571 0.0 GO:0080134 5 regulation of response to stress 340 358 13 13 10 8 6 6 32 352 2157 0.72011 0.44831 0.8129 1.68 363328;89829;25106;316351;60628;24253 ticam1;socs3;rgn;npas2;cxcr4;cebpb TICAM1_10015;SOCS3_32863;RGN_9699;NPAS2_9350;CXCR4_8411;CEBPB_32843,CEBPB_8282 24253(-0.009836) 524.8200000000003 686.823 1.65461E-12 356.7029205347213 541.4757203526257 345.9079376459987 324.0523333333336 434.1325 1.65461E-12 217.2370461792059 333.22480973553104 209.38932631272937 1394.4875000000002 1637.31 1.65462E-12 1018.4645086587452 1463.9363846301264 1011.0701997275606 811.122;809.124;752.835;155.028;1.65461E-12;620.8109999999999 489.389;488.627;458.716;98.033;1.65461E-12;409.549 2362.87;2346.74;1994.77;382.695;1.65462E-12;1279.85 1 6 1 89829 SOCS3_32863 809.124 809.124 488.627 488.627 2346.74 2346.74 809.124 488.627 2346.74 5 363328;25106;316351;60628;24253 TICAM1_10015;RGN_9699;NPAS2_9350;CXCR4_8411;CEBPB_32843,CEBPB_8282 467.95920000000035 620.8109999999999 367.14790966679845 291.13740000000035 409.549 225.53153109554268 1204.0370000000003 1279.85 1012.2015595324871 811.122;752.835;155.028;1.65461E-12;620.8109999999999 489.389;458.716;98.033;1.65461E-12;409.549 2362.87;1994.77;382.695;1.65462E-12;1279.85 0 Exp 2,1(0.15);Hill,1(0.15);Linear,4(0.58);Poly 2,1(0.15) 1.646939184683708 11.543192148208618 1.5415632724761963 1.744480013847351 0.08940993509289627 1.671766996383667 239.3982192769367 810.2417807230638 150.2264939862966 497.8781726803706 579.5461666662202 2209.42883333378 DOWN 0.16666666666666666 0.8333333333333334 0.0 GO:0070301 6 cellular response to hydrogen peroxide 41 45 2 2 2 2 2 2 36 43 2466 0.97174 0.14399 0.14399 4.44 24314;361921 nqo1;ect2 NQO1_33055;ECT2_8523 35.8915 35.8915 31.2319 6.5896695152336715 39.13461542649728 4.731611668430791 19.02785 19.02785 16.4725 3.6138106266100887 20.80639215063521 2.594841590892937 73.27485 73.27485 67.1945 8.598913433975278 77.50681774047187 6.174318612787192 40.5511;31.2319 21.5832;16.4725 79.3552;67.1945 1 1 1 24314 NQO1_33055 40.5511 40.5511 21.5832 21.5832 79.3552 79.3552 40.5511 21.5832 79.3552 1 361921 ECT2_8523 31.2319 31.2319 16.4725 16.4725 67.1945 67.1945 31.2319 16.4725 67.1945 0 Exp 4,2(1) 2.357211652161971 4.733629941940308 2.1538212299346924 2.5798087120056152 0.30121863727293235 2.366814970970154 26.758684000000002 45.024316 14.019364 24.036336000000002 61.35736400000001 85.192336 CONFLICT 0.5 0.5 0.0 GO:0031347 6 regulation of defense response 154 164 8 8 6 5 4 4 34 160 2349 0.90649 0.22606 0.30427 2.44 363328;89829;316351;24253 ticam1;socs3;npas2;cebpb TICAM1_10015;SOCS3_32863;NPAS2_9350;CEBPB_32843,CEBPB_8282 24253(-0.009836) 599.02125 714.9675 155.028 309.1572916595206 576.9624246437793 332.84485733461906 371.3995 449.08799999999997 98.033 186.05414672347402 355.6626945586688 200.21727301079972 1593.03875 1813.2949999999998 382.695 952.8422244385042 1565.191488237544 1010.38530418347 811.122;809.124;155.028;620.8109999999999 489.389;488.627;98.033;409.549 2362.87;2346.74;382.695;1279.85 1 4 1 89829 SOCS3_32863 809.124 809.124 488.627 488.627 2346.74 2346.74 809.124 488.627 2346.74 3 363328;316351;24253 TICAM1_10015;NPAS2_9350;CEBPB_32843,CEBPB_8282 528.987 620.8109999999999 337.5478772574344 332.32366666666667 409.549 206.7914257539062 1341.805 1279.85 991.5402534314982 811.122;155.028;620.8109999999999 489.389;98.033;409.549 2362.87;382.695;1279.85 0 Linear,4(0.8);Poly 2,1(0.2) 1.614991300218713 8.083862662315369 1.5415632724761963 1.7404011487960815 0.08561423640680707 1.5669527053833008 296.0471041736696 901.9953958263304 189.06643621099545 553.7325637890045 659.2533700502659 2526.824129949734 DOWN 0.25 0.75 0.0 GO:0051346 6 negative regulation of hydrolase activity 118 128 5 4 4 4 3 3 35 125 2384 0.87944 0.2979 0.43679 2.34 299276;25106;83928 serpina3m;rgn;fetub SERPINA3M_9809;RGN_9699;FETUB_33027 588.532 545.901 466.86 147.6769338014571 541.2825992258363 120.63131423851011 379.00199999999995 382.164 296.126 81.34110712302892 353.62336206597723 73.57790486456875 1296.7103333333334 976.618 918.743 605.2295866663601 1110.2732168813911 470.5908584587736 466.86;752.835;545.901 296.126;458.716;382.164 918.743;1994.77;976.618 1 2 1 83928 FETUB_33027 545.901 545.901 382.164 382.164 976.618 976.618 545.901 382.164 976.618 2 299276;25106 SERPINA3M_9809;RGN_9699 609.8475000000001 609.8475000000001 202.21486174982272 377.421 377.421 114.96849155312071 1456.7565 1456.7565 760.8659884398173 466.86;752.835 296.126;458.716 918.743;1994.77 0 Exp 2,3(1) 1.604155415480688 4.819293975830078 1.5054508447647095 1.7148494720458984 0.10489726133854468 1.5989936590194702 421.419817732595 755.6441822674051 286.9558722164211 471.04812778357893 611.8285823579693 1981.5920843086976 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0019369 6 arachidonic acid metabolic process 29 34 3 3 3 3 3 3 35 31 2478 0.99858 0.013333 0.013333 8.82 266674;266684;29277 cyp4a8;cyp2d1;cyp2c11 CYP4A8_32747;CYP2D1_32660;CYP2C11_32593 140.04953333333333 126.747 76.6586 70.983292581095 148.41192582548388 62.07757197163057 94.17726666666665 85.1532 57.8156 41.614116428122486 98.70830874650657 36.753320632141296 244.135 250.579 112.882 128.15256849942568 267.92975012938626 104.09216035715296 0.5 101.7028 76.6586;126.747;216.743 57.8156;85.1532;139.563 112.882;250.579;368.944 2 1 2 266674;266684 CYP4A8_32747;CYP2D1_32660 101.7028 101.7028 35.41784729878428 71.4844 71.4844 19.3306023413654 181.7305 181.7305 97.36648244904406 76.6586;126.747 57.8156;85.1532 112.882;250.579 1 29277 CYP2C11_32593 216.743 216.743 139.563 139.563 368.944 368.944 216.743 139.563 368.944 0 Exp 2,1(0.34);Poly 2,2(0.67) 2.7408856717877397 11.493285775184631 1.5671749114990234 8.3532075881958 3.916265203742164 1.5729032754898071 59.72437609719748 220.37469056946918 47.08646087581137 141.26807245752195 99.11671695584866 389.1532830441514 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0044281 3 small molecule metabolic process 449 498 15 15 11 13 10 10 28 488 2021 0.8939 0.19349 0.30222 2.01 25044;25106;24450;60671;266674;266684;29277;24296;25612;54223 sds;rgn;hmgcs2;gulo;cyp4a8;cyp2d1;cyp2c11;cyp1a1;asns;adcy4 SDS_9798;RGN_9699;HMGCS2_8812;GULO_8772;CYP4A8_32747;CYP2D1_32660;CYP2C11_32593;CYP1A1_8415;ASNS_8091;ADCY4_7988 295.02465 175.877 49.0449 271.07991693896906 251.12452148288975 261.7977819997395 182.33861000000002 105.92015 39.2363 160.9558775423145 153.5613814774579 152.63130661981512 753.41459 370.0815 64.8529 760.8164600314242 631.1457157669328 749.4413725317502 553.681;752.835;106.351;193.989;76.6586;126.747;216.743;49.0449;157.765;716.432 377.484;458.716;59.8697;112.274;57.8156;85.1532;139.563;39.2363;99.5663;393.708 1035.66;1994.77;208.329;1039.83;112.882;250.579;368.944;64.8529;371.219;2087.08 6 4 6 25044;60671;266674;266684;24296;25612 SDS_9798;GULO_8772;CYP4A8_32747;CYP2D1_32660;CYP1A1_8415;ASNS_8091 192.98091666666667 142.256 184.38064817161717 128.58823333333333 92.35974999999999 124.84924126982375 479.1704833333333 310.899 445.81466500711 553.681;193.989;76.6586;126.747;49.0449;157.765 377.484;112.274;57.8156;85.1532;39.2363;99.5663 1035.66;1039.83;112.882;250.579;64.8529;371.219 4 25106;24450;29277;54223 RGN_9699;HMGCS2_8812;CYP2C11_32593;ADCY4_7988 448.09025 466.5875 334.25734722353775 262.964175 266.6355 193.1216719526557 1164.78075 1181.857 1014.5071290031678 752.835;106.351;216.743;716.432 458.716;59.8697;139.563;393.708 1994.77;208.329;368.944;2087.08 0 Exp 2,3(0.3);Exp 4,1(0.1);Linear,1(0.1);Poly 2,5(0.5) 2.3528334377656943 30.99097466468811 1.5452189445495605 8.822484970092773 2.9111957020691865 1.6254180669784546 127.00757677054534 463.04172322945476 82.57712353832774 282.1000964616723 281.8556625710309 1224.9735174289692 UP 0.6 0.4 0.0 GO:0006631 6 fatty acid metabolic process 129 145 5 5 4 5 4 4 34 141 2368 0.93851 0.16728 0.16728 2.76 266674;266684;29277;24296 cyp4a8;cyp2d1;cyp2c11;cyp1a1 CYP4A8_32747;CYP2D1_32660;CYP2C11_32593;CYP1A1_8415 117.298375 101.7028 49.0449 73.68545337538363 98.0437177062066 70.56743208275736 80.442025 71.4844 39.2363 43.69344625107788 68.56250847795017 42.0812811365199 199.31447500000002 181.7305 64.8529 137.78330227971202 164.99201030522661 135.99042097950678 76.6586;126.747;216.743;49.0449 57.8156;85.1532;139.563;39.2363 112.882;250.579;368.944;64.8529 3 1 3 266674;266684;24296 CYP4A8_32747;CYP2D1_32660;CYP1A1_8415 84.15016666666666 76.6586 39.3890437106987 60.73503333333334 57.8156 23.097245390810844 142.7713 112.882 96.40318327819887 76.6586;126.747;49.0449 57.8156;85.1532;39.2363 112.882;250.579;64.8529 1 29277 CYP2C11_32593 216.743 216.743 139.563 139.563 368.944 368.944 216.743 139.563 368.944 0 Exp 2,1(0.25);Poly 2,3(0.75) 3.671266591334651 20.315770745277405 1.5671749114990234 8.822484970092773 4.056260376776291 4.963055431842804 45.08663069212405 189.51011930787593 37.622447673943654 123.26160232605632 64.28683876588221 334.34211123411785 UP 0.75 0.25 0.0 GO:0045787 6 positive regulation of cell cycle 111 119 12 11 9 7 5 5 33 114 2395 0.99259 0.029855 0.029855 4.2 363140;315740;361921;24296;25612 rassf1;kif23;ect2;cyp1a1;asns RASSF1_32475;KIF23_32798;ECT2_8523;CYP1A1_8415;ASNS_8091 230.44557999999998 49.0449 10.3381 380.7206606314359 320.1322884967689 437.8375318401498 153.605076 39.2363 4.23628 256.93331624618065 215.7659113601857 294.39273011286184 339.33858 67.1945 21.7065 485.8420825200891 442.95333521237217 557.1060047737612 903.848;10.3381;31.2319;49.0449;157.765 608.514;4.23628;16.4725;39.2363;99.5663 1171.72;21.7065;67.1945;64.8529;371.219 3 2 3 363140;24296;25612 RASSF1_32475;CYP1A1_8415;ASNS_8091 370.2193 157.765 465.322154140301 249.10553333333334 99.5663 312.7151445945069 535.9306333333334 371.219 571.5208971525917 903.848;49.0449;157.765 608.514;39.2363;99.5663 1171.72;64.8529;371.219 2 315740;361921 KIF23_32798;ECT2_8523 20.785 20.785 14.774147664755489 10.35439 10.35439 8.652314138090459 44.450500000000005 44.450500000000005 32.16487326261366 10.3381;31.2319 4.23628;16.4725 21.7065;67.1945 0 Exp 4,1(0.2);Exp 5,1(0.2);Poly 2,3(0.6) 2.6421817801708474 16.82623851299286 1.595955729484558 8.822484970092773 3.0822833317754217 2.1538212299346924 -103.27079282332332 564.1619528233233 -71.60690543787712 378.8170574378771 -86.52078175523275 765.1979417552327 UP 0.6 0.4 0.0 GO:0065008 3 regulation of biological quality 821 880 18 17 12 16 11 11 27 869 1640 0.29219 0.81599 0.4982 1.25 362246;363328;25106;363140;24314;24567;24296;60628;170945;24253;25748 tp53inp2;ticam1;rgn;rassf1;nqo1;mt1;cyp1a1;cxcr4;chrna2;cebpb;alas2 TP53INP2_32755;TICAM1_10015;RGN_9699;RASSF1_32475;NQO1_33055;MT1A_9255;CYP1A1_8415;CXCR4_8411;CHRNA2_32401;CEBPB_32843,CEBPB_8282;ALAS2_8019 24253(-0.009836) 439.2261000000001 592.031 1.65461E-12 371.0158343813804 405.913020750741 393.4298758101312 278.1280181818184 396.105 1.65461E-12 235.2793595710884 259.07922113598954 252.78617728803619 1087.5674636363638 1171.72 1.65462E-12 930.6446640730651 952.2306384771156 925.7871519324003 827.265;811.122;752.835;903.848;40.5511;168.588;49.0449;1.65461E-12;592.031;620.8109999999999;65.3911 495.492;489.389;458.716;608.514;21.5832;103.554;39.2363;1.65461E-12;396.105;409.549;37.2697 2498.6;2362.87;1994.77;1171.72;79.3552;1208.95;64.8529;1.65462E-12;1168.63;1279.85;133.644 3 9 3 363140;24314;24296 RASSF1_32475;NQO1_33055;CYP1A1_8415 331.14799999999997 49.0449 495.9909310255683 223.11116666666666 39.2363 333.8853335217397 438.64270000000005 79.3552 634.9049732107869 903.848;40.5511;49.0449 608.514;21.5832;39.2363 1171.72;79.3552;64.8529 8 362246;363328;25106;24567;60628;170945;24253;25748 TP53INP2_32755;TICAM1_10015;RGN_9699;MT1A_9255;CXCR4_8411;CHRNA2_32401;CEBPB_32843,CEBPB_8282;ALAS2_8019 479.75538750000015 606.4209999999999 345.65256586781044 298.75933750000024 402.827 213.1797249718709 1330.9142500000003 1244.4 934.8594198068724 827.265;811.122;752.835;168.588;1.65461E-12;592.031;620.8109999999999;65.3911 495.492;489.389;458.716;103.554;1.65461E-12;396.105;409.549;37.2697 2498.6;2362.87;1994.77;1208.95;1.65462E-12;1168.63;1279.85;133.644 0 Exp 2,1(0.09);Exp 4,1(0.09);Exp 5,1(0.09);Hill,1(0.09);Linear,5(0.42);Poly 2,3(0.25) 2.106273191278896 29.52468192577362 1.5415632724761963 8.822484970092773 2.038348659051439 1.7296647429466248 219.96975315541724 658.4824468445829 139.0868019126973 417.16923445093937 537.5916126183337 1637.5433146543942 DOWN 0.2727272727272727 0.7272727272727273 0.0 GO:0010557 7 positive regulation of macromolecule biosynthetic process 371 401 10 10 7 9 6 6 32 395 2114 0.60995 0.56633 1.0 1.5 362246;360243;363328;316351;114519;24253 tp53inp2;top2a;ticam1;npas2;nfil3;cebpb TP53INP2_32755;TOP2A_10059;TICAM1_10015;NPAS2_9350;NFIL3_9304;CEBPB_32843,CEBPB_8282 24253(-0.009836) 424.64686666666665 387.91949999999997 12.3342 370.0398375650204 376.87611402674054 370.95099203551655 263.0797783333333 253.791 3.46407 225.35115518276365 232.58116475728744 224.92471303562255 1133.3886166666668 831.2724999999999 46.5267 1091.6206046058683 1019.4419177788484 1102.0955816589817 827.265;12.3342;811.122;155.028;121.321;620.8109999999999 495.492;3.46407;489.389;98.033;82.5516;409.549 2498.6;46.5267;2362.87;382.695;229.79;1279.85 0 7 0 6 362246;360243;363328;316351;114519;24253 TP53INP2_32755;TOP2A_10059;TICAM1_10015;NPAS2_9350;NFIL3_9304;CEBPB_32843,CEBPB_8282 424.64686666666665 387.91949999999997 370.0398375650204 263.0797783333333 253.791 225.35115518276365 1133.3886166666668 831.2724999999999 1091.6206046058683 827.265;12.3342;811.122;155.028;121.321;620.8109999999999 495.492;3.46407;489.389;98.033;82.5516;409.549 2498.6;46.5267;2362.87;382.695;229.79;1279.85 0 Hill,1(0.15);Linear,4(0.58);Poly 2,2(0.29) 1.7991977433018609 12.921800971031189 1.5415632724761963 2.846071243286133 0.4920388730423956 1.5739303827285767 128.5533297313542 720.7404036019792 82.7612995727902 443.3982570938764 259.91021516233684 2006.8670181709963 DOWN 0.0 1.0 0.0 GO:0048252 8 lauric acid metabolic process 3 4 1 1 1 1 1 1 37 3 2506 0.99872 0.058389 0.058389 25.0 266674 cyp4a8 CYP4A8_32747 76.6586 76.6586 76.6586 76.6586 57.8156 57.8156 57.8156 57.8156 112.882 112.882 112.882 112.882 0.0 76.6586 0.0 76.6586 76.6586 57.8156 112.882 1 0 1 266674 CYP4A8_32747 76.6586 76.6586 57.8156 57.8156 112.882 112.882 76.6586 57.8156 112.882 0 0 Poly 2,1(1) 1.5729032754898071 1.5729032754898071 1.5729032754898071 1.5729032754898071 0.0 1.5729032754898071 76.6586 76.6586 57.8156 57.8156 112.882 112.882 UP 1.0 0.0 0.0 GO:0071310 5 cellular response to organic substance 516 551 18 15 12 12 9 9 29 542 1967 0.70345 0.44153 0.6955 1.63 363328;89829;114519;24587;24450;24296;60628;24253;25612 ticam1;socs3;nfil3;nefh;hmgcs2;cyp1a1;cxcr4;cebpb;asns TICAM1_10015;SOCS3_32863;NFIL3_9304;NEFH_33218;HMGCS2_8812;CYP1A1_8415;CXCR4_8411;CEBPB_32843,CEBPB_8282;ASNS_8091 24253(-0.009836) 297.2821000000005 121.321 1.65461E-12 345.67715046707906 280.800303441066 332.37213625944247 185.42098888888938 82.5516 1.65461E-12 211.66362368751132 174.79436521496729 201.90606945410886 762.6278777777783 229.79 1.65462E-12 983.1175939495912 719.8017461198401 967.0321853844583 811.122;809.124;121.321;2.95157E-12;106.351;49.0449;1.65461E-12;620.8109999999999;157.765 489.389;488.627;82.5516;2.95157E-12;59.8697;39.2363;1.65461E-12;409.549;99.5663 2362.87;2346.74;229.79;2.95158E-12;208.329;64.8529;1.65462E-12;1279.85;371.219 3 7 3 89829;24296;25612 SOCS3_32863;CYP1A1_8415;ASNS_8091 338.64463333333333 157.765 411.0573450022556 209.14319999999998 99.5663 243.91253160063349 927.6039666666666 371.219 1238.5174030412747 809.124;49.0449;157.765 488.627;39.2363;99.5663 2346.74;64.8529;371.219 6 363328;114519;24587;24450;60628;24253 TICAM1_10015;NFIL3_9304;NEFH_33218;HMGCS2_8812;CXCR4_8411;CEBPB_32843,CEBPB_8282 276.6008333333341 113.836 349.3726923624199 173.5598833333341 71.21065 217.6662241812297 680.1398333333341 219.0595 953.0827790303238 811.122;121.321;2.95157E-12;106.351;1.65461E-12;620.8109999999999 489.389;82.5516;2.95157E-12;59.8697;1.65461E-12;409.549 2362.87;229.79;2.95158E-12;208.329;1.65462E-12;1279.85 0 Exp 4,1(0.1);Hill,2(0.2);Linear,4(0.4);Poly 2,3(0.3) 2.1735785075609746 25.86830973625183 1.5415632724761963 8.822484970092773 2.2225567197622205 1.7424405813217163 71.43969502817552 523.1245049718256 47.134088079715355 323.70788969806347 120.32438306404549 1404.9313724915114 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:1901654 5 response to ketone 140 154 5 4 4 3 3 3 35 151 2358 0.80562 0.40624 0.49805 1.95 89829;24450;266674 socs3;hmgcs2;cyp4a8 SOCS3_32863;HMGCS2_8812;CYP4A8_32747 330.7112 106.351 76.6586 414.58354412267744 370.44220935563095 420.28255962420906 202.10410000000002 59.8697 57.8156 248.13823566715791 222.39781256578178 254.99203497396778 889.317 208.329 112.882 1263.0672520293601 1011.4638577359374 1279.3134296218486 809.124;106.351;76.6586 488.627;59.8697;57.8156 2346.74;208.329;112.882 2 1 2 89829;266674 SOCS3_32863;CYP4A8_32747 442.8913 442.8913 517.9312513245171 273.2213 273.2213 304.62966235247023 1229.811 1229.811 1579.5761400078186 809.124;76.6586 488.627;57.8156 2346.74;112.882 1 24450 HMGCS2_8812 106.351 106.351 59.8697 59.8697 208.329 208.329 106.351 59.8697 208.329 0 Exp 4,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 1.9182666244665418 5.891854286193848 1.5729032754898071 2.578549861907959 0.5388063751830989 1.7404011487960815 -138.43424476960115 799.8566447696012 -78.69074723099794 482.898947230998 -539.9781472089539 2318.612147208954 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0034654 5 nucleobase-containing compound biosynthetic process 143 160 3 3 3 2 2 2 36 158 2351 0.56916 0.70082 1.0 1.25 114519;54223 nfil3;adcy4 NFIL3_9304;ADCY4_7988 418.8765 418.8765 121.321 420.80702365870746 387.5983920222331 418.47569951331985 238.12980000000002 238.12980000000002 82.5516 220.02080044959388 221.7759038744483 218.80185738130595 1158.435 1158.435 229.79 1313.3023536299627 1060.8187281347066 1306.0264924511453 121.321;716.432 82.5516;393.708 229.79;2087.08 0 2 0 2 114519;54223 NFIL3_9304;ADCY4_7988 418.8765 418.8765 420.80702365870746 238.12980000000002 238.12980000000002 220.02080044959388 1158.435 1158.435 1313.3023536299627 121.321;716.432 82.5516;393.708 229.79;2087.08 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.8877401784473025 3.809406042098999 1.6510682106018066 2.1583378314971924 0.3586937888250564 1.9047030210494995 -164.33227999999997 1002.0852799999999 -66.80347200000006 543.063072 -661.7091999999996 2978.579199999999 DOWN 0.0 1.0 0.0 GO:0010033 4 response to organic substance 795 856 29 26 22 21 17 17 21 839 1670 0.94665 0.10012 0.16609 1.99 24522;360243;363328;89829;25044;24314;114519;24587;24450;170568;266674;266684;24296;60628;24253;25612;25748 zfp354a;top2a;ticam1;socs3;sds;nqo1;nfil3;nefh;hmgcs2;dmbt1;cyp4a8;cyp2d1;cyp1a1;cxcr4;cebpb;asns;alas2 ZFP354A_10203;TOP2A_10059;TICAM1_10015;SOCS3_32863;SDS_9798;NQO1_33055;NFIL3_9304;NEFH_33218;HMGCS2_8812;DMBT1_32993;CYP4A8_32747;CYP2D1_32660;CYP1A1_8415;CXCR4_8411;CEBPB_32843,CEBPB_8282;ASNS_8091;ALAS2_8019 24253(-0.009836) 214.8688958823532 99.2226 1.65461E-12 286.2355982160453 197.42791328489903 277.7781530053177 136.68893176470615 59.8697 1.65461E-12 178.5741625919483 124.00672896348036 171.87847179249826 511.44547529411795 163.536 1.65462E-12 779.4645598883974 480.20519562405116 775.8272595310625 99.2226;12.3342;811.122;809.124;553.681;40.5511;121.321;2.95157E-12;106.351;2.64673;76.6586;126.747;49.0449;1.65461E-12;620.8109999999999;157.765;65.3911 71.0566;3.46407;489.389;488.627;377.484;21.5832;82.5516;2.95157E-12;59.8697;1.09657;57.8156;85.1532;39.2363;1.65461E-12;409.549;99.5663;37.2697 163.536;46.5267;2362.87;2346.74;1035.66;79.3552;229.79;2.95158E-12;208.329;8.73928;112.882;250.579;64.8529;1.65462E-12;1279.85;371.219;133.644 8 10 8 89829;25044;24314;170568;266674;266684;24296;25612 SOCS3_32863;SDS_9798;NQO1_33055;DMBT1_32993;CYP4A8_32747;CYP2D1_32660;CYP1A1_8415;ASNS_8091 227.02729125000002 101.7028 292.7214928546476 146.32027125 71.4844 182.24286172600887 533.7534224999999 181.7305 803.9681748767582 809.124;553.681;40.5511;2.64673;76.6586;126.747;49.0449;157.765 488.627;377.484;21.5832;1.09657;57.8156;85.1532;39.2363;99.5663 2346.74;1035.66;79.3552;8.73928;112.882;250.579;64.8529;371.219 9 24522;360243;363328;114519;24587;24450;60628;24253;25748 ZFP354A_10203;TOP2A_10059;TICAM1_10015;NFIL3_9304;NEFH_33218;HMGCS2_8812;CXCR4_8411;CEBPB_32843,CEBPB_8282;ALAS2_8019 204.0614333333338 99.2226 297.6697315146684 128.12774111111165 59.8697 185.85301070507992 491.6161888888894 163.536 805.3699659928941 99.2226;12.3342;811.122;121.321;2.95157E-12;106.351;1.65461E-12;620.8109999999999;65.3911 71.0566;3.46407;489.389;82.5516;2.95157E-12;59.8697;1.65461E-12;409.549;37.2697 163.536;46.5267;2362.87;229.79;2.95158E-12;208.329;1.65462E-12;1279.85;133.644 0 Exp 4,3(0.17);Exp 5,1(0.06);Hill,3(0.17);Linear,5(0.28);Poly 2,6(0.34) 2.029437151909608 41.17540407180786 1.5415632724761963 8.822484970092773 1.6851449436148938 1.7268086671829224 78.80112962923783 350.9366621354685 51.80016333113339 221.57770019827888 140.91154381076046 881.979406777475 CONFLICT 0.47058823529411764 0.5294117647058824 0.0 GO:0043067 6 regulation of programmed cell death 435 463 15 15 13 11 9 9 29 454 2055 0.86299 0.24242 0.39511 1.94 360243;89829;25106;24314;24567;361921;60628;24253;25612 top2a;socs3;rgn;nqo1;mt1;ect2;cxcr4;cebpb;asns TOP2A_10059;SOCS3_32863;RGN_9699;NQO1_33055;MT1A_9255;ECT2_8523;CXCR4_8411;CEBPB_32843,CEBPB_8282;ASNS_8091 24253(-0.009836) 288.1378000000002 157.765 1.65461E-12 338.32706457101153 285.06292589043767 335.878412726796 177.94800777777795 99.5663 1.65461E-12 210.14986096486712 175.00120908488202 207.62678919780748 821.6228222222223 371.219 1.65462E-12 912.4880941622945 861.9404278890826 929.2417054392021 12.3342;809.124;752.835;40.5511;168.588;31.2319;1.65461E-12;620.8109999999999;157.765 3.46407;488.627;458.716;21.5832;103.554;16.4725;1.65461E-12;409.549;99.5663 46.5267;2346.74;1994.77;79.3552;1208.95;67.1945;1.65462E-12;1279.85;371.219 3 7 3 89829;24314;25612 SOCS3_32863;NQO1_33055;ASNS_8091 335.8133666666667 157.765 414.06761683099944 203.25883333333334 99.5663 250.1930931928844 932.4380666666666 371.219 1233.4843284008164 809.124;40.5511;157.765 488.627;21.5832;99.5663 2346.74;79.3552;371.219 6 360243;25106;24567;361921;60628;24253 TOP2A_10059;RGN_9699;MT1A_9255;ECT2_8523;CXCR4_8411;CEBPB_32843,CEBPB_8282 264.300016666667 99.90995 335.43682561616504 165.29259500000026 60.01325 212.23933388474916 766.2152000000002 638.07225 844.1384858276391 12.3342;752.835;168.588;31.2319;1.65461E-12;620.8109999999999 3.46407;458.716;103.554;16.4725;1.65461E-12;409.549 46.5267;1994.77;1208.95;67.1945;1.65462E-12;1279.85 0 Exp 2,1(0.1);Exp 4,2(0.2);Hill,2(0.2);Linear,3(0.3);Poly 2,2(0.2) 1.9290688053219243 19.68617534637451 1.5669527053833008 2.846071243286133 0.43968819361409284 1.7424405813217163 67.09745114693933 509.1781488530611 40.650098614064774 315.24591694149115 225.46393403619004 1417.7817104082549 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0009967 6 positive regulation of signal transduction 363 381 3 3 3 2 2 2 36 379 2130 0.06099 0.98427 0.10836 0.52 363328;60628 ticam1;cxcr4 TICAM1_10015;CXCR4_8411 405.56100000000083 405.56100000000083 1.65461E-12 573.5498665695935 522.5258573304163 549.1792910710943 244.69450000000083 244.69450000000083 1.65461E-12 346.0502805381022 315.2650363238518 331.3463376384705 1181.4350000000009 1181.4350000000009 1.65462E-12 1670.801400062256 1522.1639562363243 1599.8077619558564 811.122;1.65461E-12 489.389;1.65461E-12 2362.87;1.65462E-12 0 2 0 2 363328;60628 TICAM1_10015;CXCR4_8411 405.56100000000083 405.56100000000083 573.5498665695935 244.69450000000083 244.69450000000083 346.0502805381022 1181.4350000000009 1181.4350000000009 1670.801400062256 811.122;1.65461E-12 489.389;1.65461E-12 2362.87;1.65462E-12 0 Hill,1(0.5);Linear,1(0.5) 1.6398860688827877 3.2860432863235474 1.5415632724761963 1.744480013847351 0.1434838038398204 1.6430216431617737 -389.3385599999973 1200.460559999999 -234.90671999999748 724.2957199999992 -1134.1775999999968 3497.0475999999985 DOWN 0.0 1.0 0.0 GO:0033273 5 response to vitamin 73 78 5 5 3 4 3 3 35 75 2434 0.97271 0.10857 0.10857 3.85 24522;25044;24296 zfp354a;sds;cyp1a1 ZFP354A_10203;SDS_9798;CYP1A1_8415 233.98283333333333 99.2226 49.0449 278.00114877792026 162.46472821905832 246.30570914092948 162.5923 71.0566 39.2363 186.78052607188468 114.94717735106782 165.21622583205425 421.3496333333333 163.536 64.8529 534.2915950134378 283.4180053640565 473.6954014646729 99.2226;553.681;49.0449 71.0566;377.484;39.2363 163.536;1035.66;64.8529 2 1 2 25044;24296 SDS_9798;CYP1A1_8415 301.36295 301.36295 356.83160834153284 208.36014999999998 208.36014999999998 239.17724239075295 550.2564500000001 550.2564500000001 686.4642836340468 553.681;49.0449 377.484;39.2363 1035.66;64.8529 1 24522 ZFP354A_10203 99.2226 99.2226 71.0566 71.0566 163.536 163.536 99.2226 71.0566 163.536 0 Linear,1(0.34);Poly 2,2(0.67) 2.923879833309549 12.201274394989014 1.5452189445495605 8.822484970092773 4.120814506051463 1.8335704803466797 -80.6050813073033 548.57074797397 -48.76976253368579 373.95436253368575 -183.25822323192176 1025.9574898985884 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0006996 5 organelle organization 397 425 23 23 13 14 8 8 30 417 2092 0.82994 0.29364 0.5085 1.88 24522;362246;360243;304951;24587;291885;315740;361308 zfp354a;tp53inp2;top2a;nuf2;nefh;mcm5;kif23;kif20a ZFP354A_10203;TP53INP2_32755;TOP2A_10059;NUF2_33136;NEFH_33218;MCM5_9209;KIF23_32798;KIF20A_8961 125.81104000000036 12.4174 2.95157E-12 285.1906637051633 188.067110612057 349.09301281777715 75.46858625000037 6.97687 2.95157E-12 171.28957933150113 112.18326966099319 209.7106055869732 362.60053750000037 42.16605 2.95158E-12 864.5891570096134 554.7159472163124 1059.1073615855987 99.2226;827.265;12.3342;9.55312;2.95157E-12;12.5006;10.3381;35.2747 71.0566;495.492;3.46407;4.27871;2.95157E-12;9.67503;4.23628;15.546 163.536;2498.6;46.5267;37.8054;2.95158E-12;36.0856;21.7065;96.5441 0 8 0 8 24522;362246;360243;304951;24587;291885;315740;361308 ZFP354A_10203;TP53INP2_32755;TOP2A_10059;NUF2_33136;NEFH_33218;MCM5_9209;KIF23_32798;KIF20A_8961 125.81104000000036 12.4174 285.1906637051633 75.46858625000037 6.97687 171.28957933150113 362.60053750000037 42.16605 864.5891570096134 99.2226;827.265;12.3342;9.55312;2.95157E-12;12.5006;10.3381;35.2747 71.0566;495.492;3.46407;4.27871;2.95157E-12;9.67503;4.23628;15.546 163.536;2498.6;46.5267;37.8054;2.95158E-12;36.0856;21.7065;96.5441 0 Exp 4,1(0.13);Exp 5,3(0.38);Hill,2(0.25);Linear,1(0.13);Poly 2,1(0.13) 1.9309474144435552 15.75797438621521 1.5739303827285767 2.846071243286133 0.4449029462123166 1.8056029677391052 -71.81600719227254 323.4380871922733 -43.22903638005725 194.16620888005804 -236.52918124462064 961.7302562446213 DOWN 0.0 1.0 0.0 GO:0046916 9 cellular transition metal ion homeostasis 20 23 2 2 2 2 2 2 36 21 2488 0.99558 0.045041 0.045041 8.7 24567;25748 mt1;alas2 MT1A_9255;ALAS2_8019 116.98955 116.98955 65.3911 72.97122778743002 114.54182057929147 72.8890754926346 70.41185 70.41185 37.2697 46.870078016203465 68.83965130758705 46.817310856008696 671.297 671.297 133.644 760.3561644505816 645.7917945871978 759.5001420748396 0.5 116.98955 168.588;65.3911 103.554;37.2697 1208.95;133.644 0 2 0 2 24567;25748 MT1A_9255;ALAS2_8019 116.98955 116.98955 72.97122778743002 70.41185 70.41185 46.870078016203465 671.297 671.297 760.3561644505816 168.588;65.3911 103.554;37.2697 1208.95;133.644 0 Exp 5,1(0.5);Poly 2,1(0.5) 1.8823839900695505 3.781472086906433 1.7132161855697632 2.06825590133667 0.2510509906093242 1.8907360434532166 15.856588000000002 218.12251199999997 5.453236000000004 135.370464 -382.50288 1725.09688 DOWN 0.0 1.0 0.0 GO:0000122 9 negative regulation of transcription by RNA polymerase II 174 180 6 6 4 5 3 3 35 177 2332 0.72064 0.51018 0.748 1.67 24522;114519;24253 zfp354a;nfil3;cebpb ZFP354A_10203;NFIL3_9304;CEBPB_32843,CEBPB_8282 24253(-0.009836) 280.4515333333333 121.321 99.2226 294.9669637990894 254.0585278239013 276.86584811557265 187.71906666666666 82.5516 71.0566 192.19631434617398 170.074214167111 180.73530107835023 557.7253333333333 229.79 163.536 626.2550788499309 504.680557392033 585.6067913670194 99.2226;121.321;620.8109999999999 71.0566;82.5516;409.549 163.536;229.79;1279.85 0 4 0 3 24522;114519;24253 ZFP354A_10203;NFIL3_9304;CEBPB_32843,CEBPB_8282 280.4515333333333 121.321 294.9669637990894 187.71906666666666 82.5516 192.19631434617398 557.7253333333333 229.79 626.2550788499309 99.2226;121.321;620.8109999999999 71.0566;82.5516;409.549 163.536;229.79;1279.85 0 Linear,2(0.5);Poly 2,2(0.5) 1.7943706906179007 7.23062801361084 1.5669527053833008 2.1583378314971924 0.2582332308676336 1.7526687383651733 -53.33500833151038 614.238074998177 -29.771537230367613 405.2096705637009 -150.94900184320738 1266.3996685098741 DOWN 0.0 1.0 0.0 GO:0002735 9 positive regulation of myeloid dendritic cell cytokine production 2 3 1 1 1 1 1 1 37 2 2507 0.99936 0.044111 0.044111 33.33 363328 ticam1 TICAM1_10015 811.122 811.122 811.122 811.122 489.389 489.389 489.389 489.389 2362.87 2362.87 2362.87 2362.87 0.0 811.122 0.0 811.122 811.122 489.389 2362.87 0 1 0 1 363328 TICAM1_10015 811.122 811.122 489.389 489.389 2362.87 2362.87 811.122 489.389 2362.87 0 Linear,1(1) 1.5415632724761963 1.5415632724761963 1.5415632724761963 1.5415632724761963 0.0 1.5415632724761963 811.122 811.122 489.389 489.389 2362.87 2362.87 DOWN 0.0 1.0 0.0 GO:0044282 4 small molecule catabolic process 107 120 3 3 2 2 2 2 36 118 2391 0.73517 0.5417 0.6993 1.67 25044;24296 sds;cyp1a1 SDS_9798;CYP1A1_8415 301.36295 301.36295 49.0449 356.83160834153284 175.62267855310802 309.36639278455715 208.36014999999998 208.36014999999998 39.2363 239.17724239075295 124.0789073098974 207.36223749484634 550.2564500000001 550.2564500000001 64.8529 686.4642836340468 308.3602632694629 595.1518145781422 553.681;49.0449 377.484;39.2363 1035.66;64.8529 2 0 2 25044;24296 SDS_9798;CYP1A1_8415 301.36295 301.36295 356.83160834153284 208.36014999999998 208.36014999999998 239.17724239075295 550.2564500000001 550.2564500000001 686.4642836340468 553.681;49.0449 377.484;39.2363 1035.66;64.8529 0 0 Linear,1(0.5);Poly 2,1(0.5) 3.692244698525697 10.367703914642334 1.5452189445495605 8.822484970092773 5.145804155160081 5.183851957321167 -193.18042799999995 795.906328 -123.12259600000004 539.842896 -401.134508 1501.6474080000003 UP 1.0 0.0 0.0 GO:0034599 5 cellular response to oxidative stress 95 101 4 4 3 4 3 3 35 98 2411 0.93875 0.18927 0.18927 2.97 24314;24587;361921 nqo1;nefh;ect2 NQO1_33055;NEFH_33218;ECT2_8523 23.927666666667648 31.2319 2.95157E-12 21.239392558245704 29.946252026734477 20.62969506455126 12.685233333334319 16.4725 2.95157E-12 11.279014680516017 15.921287492405865 10.978614484877141 48.849900000000986 67.1945 2.95158E-12 42.73997196571209 59.30909688395173 40.506965390356484 40.5511;2.95157E-12;31.2319 21.5832;2.95157E-12;16.4725 79.3552;2.95158E-12;67.1945 1 2 1 24314 NQO1_33055 40.5511 40.5511 21.5832 21.5832 79.3552 79.3552 40.5511 21.5832 79.3552 2 24587;361921 NEFH_33218;ECT2_8523 15.615950000001476 15.615950000001476 22.084288279338047 8.236250000001476 8.236250000001476 11.647816453093316 33.59725000000148 33.59725000000148 47.513686608437375 2.95157E-12;31.2319 2.95157E-12;16.4725 2.95158E-12;67.1945 0 Exp 4,2(0.67);Hill,1(0.34) 2.3857947775199073 7.177634954452515 2.1538212299346924 2.5798087120056152 0.21760614549694096 2.444005012512207 -0.10696859474983711 47.96230192808513 -0.0781733041654249 25.448639970834062 0.48506873366154935 97.21473126634042 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0009624 5 response to nematode 1 1 1 1 1 1 1 1 37 0 2509 1.0 0.01492 0.01492 100.0 24296 cyp1a1 CYP1A1_8415 49.0449 49.0449 49.0449 49.0449 39.2363 39.2363 39.2363 39.2363 64.8529 64.8529 64.8529 64.85290000000002 0.0 49.0449 0.0 49.0449 49.0449 39.2363 64.8529 1 0 1 24296 CYP1A1_8415 49.0449 49.0449 39.2363 39.2363 64.8529 64.8529 49.0449 39.2363 64.8529 0 0 Poly 2,1(1) 8.822484970092773 8.822484970092773 8.822484970092773 8.822484970092773 0.0 8.822484970092773 49.0449 49.0449 39.2363 39.2363 64.8529 64.8529 UP 1.0 0.0 0.0 GO:0019341 5 dibenzo-p-dioxin catabolic process 1 1 1 1 1 1 1 1 37 0 2509 1.0 0.01492 0.01492 100.0 24296 cyp1a1 CYP1A1_8415 49.0449 49.0449 49.0449 49.0449 39.2363 39.2363 39.2363 39.2363 64.8529 64.8529 64.8529 64.85290000000002 0.0 49.0449 0.0 49.0449 49.0449 39.2363 64.8529 1 0 1 24296 CYP1A1_8415 49.0449 49.0449 39.2363 39.2363 64.8529 64.8529 49.0449 39.2363 64.8529 0 0 Poly 2,1(1) 8.822484970092773 8.822484970092773 8.822484970092773 8.822484970092773 0.0 8.822484970092773 49.0449 49.0449 39.2363 39.2363 64.8529 64.8529 UP 1.0 0.0 0.0 GO:1901700 4 response to oxygen-containing compound 599 638 26 23 20 17 14 14 24 624 1885 0.96569 0.070467 0.12878 2.19 24522;363328;89829;25044;24314;24587;24567;24450;361921;266674;24296;24253;25612;25748 zfp354a;ticam1;socs3;sds;nqo1;nefh;mt1;hmgcs2;ect2;cyp4a8;cyp1a1;cebpb;asns;alas2 ZFP354A_10203;TICAM1_10015;SOCS3_32863;SDS_9798;NQO1_33055;NEFH_33218;MT1A_9255;HMGCS2_8812;ECT2_8523;CYP4A8_32747;CYP1A1_8415;CEBPB_32843,CEBPB_8282;ASNS_8091;ALAS2_8019 24253(-0.009836) 256.39587142857164 102.7868 2.95157E-12 300.4958497450668 246.02620451466638 297.4056423041782 162.2480642857145 65.46315 2.95157E-12 187.33332090062007 153.69590103018285 183.8189456521637 673.9344714285716 185.9325 2.95158E-12 839.2970260685557 677.834223637523 855.6097853033872 99.2226;811.122;809.124;553.681;40.5511;2.95157E-12;168.588;106.351;31.2319;76.6586;49.0449;620.8109999999999;157.765;65.3911 71.0566;489.389;488.627;377.484;21.5832;2.95157E-12;103.554;59.8697;16.4725;57.8156;39.2363;409.549;99.5663;37.2697 163.536;2362.87;2346.74;1035.66;79.3552;2.95158E-12;1208.95;208.329;67.1945;112.882;64.8529;1279.85;371.219;133.644 6 9 6 89829;25044;24314;266674;24296;25612 SOCS3_32863;SDS_9798;NQO1_33055;CYP4A8_32747;CYP1A1_8415;ASNS_8091 281.1374333333333 117.2118 323.0575455598131 180.71873333333335 78.69095 200.27798949378004 668.4515166666666 242.0505 901.0954134481706 809.124;553.681;40.5511;76.6586;49.0449;157.765 488.627;377.484;21.5832;57.8156;39.2363;99.5663 2346.74;1035.66;79.3552;112.882;64.8529;371.219 8 24522;363328;24587;24567;24450;361921;24253;25748 ZFP354A_10203;TICAM1_10015;NEFH_33218;MT1A_9255;HMGCS2_8812;ECT2_8523;CEBPB_32843,CEBPB_8282;ALAS2_8019 237.83970000000033 102.7868 303.69449269875014 148.39506250000036 65.46315 189.76694210792874 678.0466875000004 185.9325 853.3357314148703 99.2226;811.122;2.95157E-12;168.588;106.351;31.2319;620.8109999999999;65.3911 71.0566;489.389;2.95157E-12;103.554;59.8697;16.4725;409.549;37.2697 163.536;2362.87;2.95158E-12;1208.95;208.329;67.1945;1279.85;133.644 0 Exp 4,3(0.2);Exp 5,1(0.07);Hill,1(0.07);Linear,5(0.34);Poly 2,5(0.34) 2.0698779711833866 35.432286620140076 1.5415632724761963 8.822484970092773 1.826541095279266 1.7404011487960815 98.98651920347575 413.80522365366744 64.11686973457675 260.3792588368523 234.2838030084178 1113.5851398487252 CONFLICT 0.42857142857142855 0.5714285714285714 0.0 GO:0010468 6 regulation of gene expression 723 775 21 21 13 14 8 8 30 767 1742 0.13709 0.92991 0.28568 1.03 24522;362246;360243;363328;316351;114519;499271;24253 zfp354a;tp53inp2;top2a;ticam1;npas2;nfil3;itgax;cebpb ZFP354A_10203;TP53INP2_32755;TOP2A_10059;TICAM1_10015;NPAS2_9350;NFIL3_9304;ITGAX_32980;CEBPB_32843,CEBPB_8282 24253(-0.009836) 349.42597499999994 151.666 12.3342 342.6052038370936 315.99916513856397 332.45660444430195 218.08990874999998 96.60849999999999 3.46407 207.97833066706679 196.32089216438723 201.14359925944166 913.1065874999999 361.84000000000003 46.5267 1009.8445377363594 836.773937007378 989.1239697736764 99.2226;827.265;12.3342;811.122;155.028;121.321;148.304;620.8109999999999 71.0566;495.492;3.46407;489.389;98.033;82.5516;95.184;409.549 163.536;2498.6;46.5267;2362.87;382.695;229.79;340.985;1279.85 0 9 0 8 24522;362246;360243;363328;316351;114519;499271;24253 ZFP354A_10203;TP53INP2_32755;TOP2A_10059;TICAM1_10015;NPAS2_9350;NFIL3_9304;ITGAX_32980;CEBPB_32843,CEBPB_8282 349.42597499999994 151.666 342.6052038370936 218.08990874999998 96.60849999999999 207.97833066706679 913.1065874999999 361.84000000000003 1009.8445377363594 99.2226;827.265;12.3342;811.122;155.028;121.321;148.304;620.8109999999999 71.0566;495.492;3.46407;489.389;98.033;82.5516;95.184;409.549 163.536;2498.6;46.5267;2362.87;382.695;229.79;340.985;1279.85 0 Hill,1(0.12);Linear,4(0.45);Poly 2,4(0.45) 1.810442352332432 16.622664213180542 1.5415632724761963 2.846071243286133 0.426206090828936 1.671766996383667 112.01268135505191 586.8392686449481 73.96827855454984 362.2115389454502 213.32002533397747 1612.8931496660225 DOWN 0.0 1.0 0.0 GO:0050792 5 regulation of viral process 53 56 3 3 3 2 2 2 36 54 2455 0.95063 0.20281 0.20281 3.57 360243;60628 top2a;cxcr4 TOP2A_10059;CXCR4_8411 6.1671000000008265 6.1671000000008265 1.65461E-12 8.721596460509945 8.859195518078321 7.846750172082309 1.7320350000008273 1.7320350000008273 1.65461E-12 2.4494673875037134 2.4881121936010206 2.203766103078904 23.263350000000827 23.263350000000827 1.65462E-12 32.899345076230965 33.41839212198268 29.599276096662756 12.3342;1.65461E-12 3.46407;1.65461E-12 46.5267;1.65462E-12 0 2 0 2 360243;60628 TOP2A_10059;CXCR4_8411 6.1671000000008265 6.1671000000008265 8.721596460509945 1.7320350000008273 1.7320350000008273 2.4494673875037134 23.263350000000827 23.263350000000827 32.899345076230965 12.3342;1.65461E-12 3.46407;1.65461E-12 46.5267;1.65462E-12 0 Hill,2(1) 2.228208787770648 4.590551257133484 1.744480013847351 2.846071243286133 0.7789426284317885 2.295275628566742 -5.9204159999975525 18.254615999999206 -1.6627535999975513 5.126823599999206 -22.332815999997543 68.85951599999919 DOWN 0.0 1.0 0.0 GO:0045471 5 response to ethanol 109 117 5 4 3 4 2 2 36 115 2394 0.74743 0.52776 0.693 1.71 24314;24450 nqo1;hmgcs2 NQO1_33055;HMGCS2_8812 73.45105 73.45105 40.5511 46.52755549139674 76.69761206823799 46.30046532681026 40.72645 40.72645 21.5832 27.07264377789876 42.615503001989275 26.94050850738251 143.84210000000002 143.84210000000002 79.3552 91.1982485753975 150.20565749593104 90.75313115927166 40.5511;106.351 21.5832;59.8697 79.3552;208.329 1 1 1 24314 NQO1_33055 40.5511 40.5511 21.5832 21.5832 79.3552 79.3552 40.5511 21.5832 79.3552 1 24450 HMGCS2_8812 106.351 106.351 59.8697 59.8697 208.329 208.329 106.351 59.8697 208.329 0 Exp 4,2(1) 2.579179210154081 5.158358573913574 2.578549861907959 2.5798087120056152 8.90141440550082E-4 2.579179286956787 8.967148000000009 137.934952 3.205680000000001 78.24722 17.447776000000005 270.23642400000006 CONFLICT 0.5 0.5 0.0 GO:0044237 3 cellular metabolic process 1201 1328 46 42 29 27 18 18 20 1310 1199 0.33333 0.7755 0.62468 1.36 362246;360243;89829;25044;25106;24314;114519;291885;24450;60671;266674;266684;29277;24296;25612;25748;26760;54223 tp53inp2;top2a;socs3;sds;rgn;nqo1;nfil3;mcm5;hmgcs2;gulo;cyp4a8;cyp2d1;cyp2c11;cyp1a1;asns;alas2;akr7a3;adcy4 TP53INP2_32755;TOP2A_10059;SOCS3_32863;SDS_9798;RGN_9699;NQO1_33055;NFIL3_9304;MCM5_9209;HMGCS2_8812;GULO_8772;CYP4A8_32747;CYP2D1_32660;CYP2C11_32593;CYP1A1_8415;ASNS_8091;ALAS2_8019;AKR7A3_8015;ADCY4_7988 272.30715 124.03399999999999 12.3342 303.021340482251 253.34494572624027 302.50467394718345 167.2665388888889 83.85239999999999 3.46407 181.08325952052112 154.49777496953678 179.63575237414116 721.8074666666666 240.1845 36.0856 886.038877624326 670.4220646480215 900.2003575991027 827.265;12.3342;809.124;553.681;752.835;40.5511;121.321;12.5006;106.351;193.989;76.6586;126.747;216.743;49.0449;157.765;65.3911;62.7952;716.432 495.492;3.46407;488.627;377.484;458.716;21.5832;82.5516;9.67503;59.8697;112.274;57.8156;85.1532;139.563;39.2363;99.5663;37.2697;48.749;393.708 2498.6;46.5267;2346.74;1035.66;1994.77;79.3552;229.79;36.0856;208.329;1039.83;112.882;250.579;368.944;64.8529;371.219;133.644;87.647;2087.08 9 9 9 89829;25044;24314;60671;266674;266684;24296;25612;26760 SOCS3_32863;SDS_9798;NQO1_33055;GULO_8772;CYP4A8_32747;CYP2D1_32660;CYP1A1_8415;ASNS_8091;AKR7A3_8015 230.03953333333337 126.747 268.66254773652855 147.83206666666666 85.1532 166.6043340435581 598.7516777777778 250.579 763.709321131502 809.124;553.681;40.5511;193.989;76.6586;126.747;49.0449;157.765;62.7952 488.627;377.484;21.5832;112.274;57.8156;85.1532;39.2363;99.5663;48.749 2346.74;1035.66;79.3552;1039.83;112.882;250.579;64.8529;371.219;87.647 9 362246;360243;25106;114519;291885;24450;29277;25748;54223 TP53INP2_32755;TOP2A_10059;RGN_9699;NFIL3_9304;MCM5_9209;HMGCS2_8812;CYP2C11_32593;ALAS2_8019;ADCY4_7988 314.5747666666667 121.321 344.85113009161654 186.70101111111114 82.5516 202.66810527590567 844.8632555555555 229.79 1025.1535658476894 827.265;12.3342;752.835;121.321;12.5006;106.351;216.743;65.3911;716.432 495.492;3.46407;458.716;82.5516;9.67503;59.8697;139.563;37.2697;393.708 2498.6;46.5267;1994.77;229.79;36.0856;208.329;368.944;133.644;2087.08 0 Exp 2,3(0.17);Exp 4,2(0.12);Exp 5,2(0.12);Hill,1(0.06);Linear,3(0.17);Poly 2,7(0.39) 2.180360235796179 47.184881806373596 1.5452189445495605 8.822484970092773 2.2082943933242984 1.72762531042099 132.3184327964982 412.29586720350176 83.6103410548906 250.9227367228872 312.47838880812213 1131.1365445252113 CONFLICT 0.5 0.5 0.0 GO:0035690 5 cellular response to drug 160 174 5 4 3 4 3 3 35 171 2338 0.74094 0.48689 0.74192 1.72 24314;361921;60628 nqo1;ect2;cxcr4 NQO1_33055;ECT2_8523;CXCR4_8411 23.927666666667218 31.2319 1.65461E-12 21.239392558246433 30.653999964460596 20.077340337237853 12.685233333333885 16.4725 1.65461E-12 11.279014680516749 16.29757025322115 10.685496347446371 48.84990000000055 67.1945 1.65462E-12 42.73997196571284 60.71080454908964 39.394732531002006 40.5511;31.2319;1.65461E-12 21.5832;16.4725;1.65461E-12 79.3552;67.1945;1.65462E-12 1 2 1 24314 NQO1_33055 40.5511 40.5511 21.5832 21.5832 79.3552 79.3552 40.5511 21.5832 79.3552 2 361921;60628 ECT2_8523;CXCR4_8411 15.615950000000828 15.615950000000828 22.084288279338963 8.236250000000828 8.236250000000828 11.647816453094235 33.59725000000083 33.59725000000083 47.5136866084383 31.2319;1.65461E-12 16.4725;1.65461E-12 67.1945;1.65462E-12 0 Exp 4,2(0.67);Hill,1(0.34) 2.1321661890437866 6.478109955787659 1.744480013847351 2.5798087120056152 0.41769199179055544 2.1538212299346924 -0.10696859475109122 47.96230192808554 -0.07817330416668256 25.448639970834456 0.48506873366026326 97.21473126634083 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0006805 4 xenobiotic metabolic process 43 62 5 5 3 4 3 3 35 59 2450 0.98735 0.063387 0.063387 4.84 266684;29277;24296 cyp2d1;cyp2c11;cyp1a1 CYP2D1_32660;CYP2C11_32593;CYP1A1_8415 130.84496666666666 126.747 49.0449 83.9241215861288 99.81546873929142 77.49086328440445 87.98416666666667 85.1532 39.2363 50.22322632431466 69.45288684574143 46.27848720860964 228.1253 250.579 64.8529 153.28397097403888 169.3093101144089 148.87357943390754 126.747;216.743;49.0449 85.1532;139.563;39.2363 250.579;368.944;64.8529 2 1 2 266684;24296 CYP2D1_32660;CYP1A1_8415 87.89595 87.89595 54.943681822435224 62.19475 62.19475 32.46815136106458 157.71595000000002 157.71595000000002 131.32818475333082 126.747;49.0449 85.1532;39.2363 250.579;64.8529 1 29277 CYP2C11_32593 216.743 216.743 139.563 139.563 368.944 368.944 216.743 139.563 368.944 0 Exp 2,1(0.34);Poly 2,2(0.67) 4.869905763367965 18.742867469787598 1.5671749114990234 8.822484970092773 4.060172098090756 8.3532075881958 35.87588285572811 225.81405047760524 31.15123592035411 144.81709741297922 54.668157867540344 401.5824421324597 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0006357 8 regulation of transcription by RNA polymerase II 343 364 11 11 7 9 5 5 33 359 2150 0.5348 0.65087 1.0 1.37 24522;360243;316351;114519;24253 zfp354a;top2a;npas2;nfil3;cebpb ZFP354A_10203;TOP2A_10059;NPAS2_9350;NFIL3_9304;CEBPB_32843,CEBPB_8282 24253(-0.009836) 201.74336 121.321 12.3342 240.13230929320608 171.06675665786202 211.3169025045702 132.930854 82.5516 3.46407 158.79515075344577 111.93136443676197 140.1762990913565 420.47954 229.79 46.5267 495.5220653363561 363.71014502796777 434.6230898331595 99.2226;12.3342;155.028;121.321;620.8109999999999 71.0566;3.46407;98.033;82.5516;409.549 163.536;46.5267;382.695;229.79;1279.85 0 6 0 5 24522;360243;316351;114519;24253 ZFP354A_10203;TOP2A_10059;NPAS2_9350;NFIL3_9304;CEBPB_32843,CEBPB_8282 201.74336 121.321 240.13230929320608 132.930854 82.5516 158.79515075344577 420.47954 229.79 495.5220653363561 99.2226;12.3342;155.028;121.321;620.8109999999999 71.0566;3.46407;98.033;82.5516;409.549 163.536;46.5267;382.695;229.79;1279.85 0 Hill,1(0.17);Linear,2(0.34);Poly 2,3(0.5) 1.8937261215774288 11.639877796173096 1.563178539276123 2.846071243286133 0.4966027362489263 1.7526687383651733 -8.741889532056405 412.2286095320564 -6.259232620156439 272.1209406201565 -13.864700797728347 854.8237807977282 DOWN 0.0 1.0 0.0 GO:0001568 4 blood vessel development 38 41 2 2 2 2 2 2 36 39 2470 0.97789 0.12368 0.12368 4.88 89829;60628 socs3;cxcr4 SOCS3_32863;CXCR4_8411 404.56200000000086 404.56200000000086 1.65461E-12 572.1370672207829 588.1078239444512 509.8653593970709 244.31350000000083 244.31350000000083 1.65461E-12 345.511465170838 355.1561462649797 307.9058104395772 1173.3700000000008 1173.3700000000008 1.65462E-12 1659.3957676817172 1705.7164968081536 1478.7862348805425 809.124;1.65461E-12 488.627;1.65461E-12 2346.74;1.65462E-12 1 1 1 89829 SOCS3_32863 809.124 809.124 488.627 488.627 2346.74 2346.74 809.124 488.627 2346.74 1 60628 CXCR4_8411 1.65461E-12 1.65461E-12 1.65461E-12 1.65461E-12 1.65462E-12 1.65462E-12 1.65461E-12 1.65461E-12 1.65462E-12 0 Hill,1(0.5);Linear,1(0.5) 1.7424393877985351 3.4848811626434326 1.7404011487960815 1.744480013847351 0.0028841931372975004 1.7424405813217163 -388.3795199999974 1197.503519999999 -234.54095999999748 723.1679599999991 -1126.4351999999967 3473.1751999999983 CONFLICT 0.5 0.5 0.0 GO:0031349 6 positive regulation of defense response 74 79 4 4 4 3 3 3 35 76 2433 0.97156 0.11173 0.11173 3.8 363328;316351;24253 ticam1;npas2;cebpb TICAM1_10015;NPAS2_9350;CEBPB_32843,CEBPB_8282 24253(-0.009836) 528.987 620.8109999999999 155.028 337.5478772574344 472.5025921381031 357.72494345819933 332.32366666666667 409.549 98.033 206.7914257539062 295.83613172490294 219.29050113702448 1341.805 1279.85 382.695 991.5402534314982 1213.5380050610092 1033.200198842463 811.122;155.028;620.8109999999999 489.389;98.033;409.549 2362.87;382.695;1279.85 0 4 0 3 363328;316351;24253 TICAM1_10015;NPAS2_9350;CEBPB_32843,CEBPB_8282 528.987 620.8109999999999 337.5478772574344 332.32366666666667 409.549 206.7914257539062 1341.805 1279.85 991.5402534314982 811.122;155.028;620.8109999999999 489.389;98.033;409.549 2362.87;382.695;1279.85 0 Linear,3(0.75);Poly 2,1(0.25) 1.5850771072659409 6.343461513519287 1.5415632724761963 1.671766996383667 0.058349939821634327 1.565065622329712 147.01561871402566 910.9583812859743 98.31713942942301 566.3301939039103 219.7715768271903 2463.8384231728096 DOWN 0.0 1.0 0.0 GO:0051270 5 regulation of cellular component movement 281 294 5 5 4 5 4 4 34 290 2219 0.54893 0.65487 1.0 1.36 25106;24587;499271;60628 rgn;nefh;itgax;cxcr4 RGN_9699;NEFH_33218;ITGAX_32980;CXCR4_8411 225.28475000000117 74.15200000000148 1.65461E-12 358.581343310342 202.77382902693864 294.48997541333586 138.47500000000116 47.59200000000148 1.65461E-12 218.15824532664257 126.0532558792995 178.84221401158635 583.9387500000012 170.49250000000148 1.65462E-12 954.1908034418037 510.33218129619513 787.4936073711392 752.835;2.95157E-12;148.304;1.65461E-12 458.716;2.95157E-12;95.184;1.65461E-12 1994.77;2.95158E-12;340.985;1.65462E-12 0 4 0 4 25106;24587;499271;60628 RGN_9699;NEFH_33218;ITGAX_32980;CXCR4_8411 225.28475000000117 74.15200000000148 358.581343310342 138.47500000000116 47.59200000000148 218.15824532664257 583.9387500000012 170.49250000000148 954.1908034418037 752.835;2.95157E-12;148.304;1.65461E-12 458.716;2.95157E-12;95.184;1.65461E-12 1994.77;2.95158E-12;340.985;1.65462E-12 0 Exp 2,1(0.25);Hill,2(0.5);Poly 2,1(0.25) 1.922213517845835 7.77062726020813 1.7148494720458984 2.444005012512207 0.34068557629284935 1.8058863878250122 -126.12496644413392 576.6944664441362 -75.32008042010858 352.2700804201109 -351.16823737296636 1519.0457373729687 DOWN 0.0 1.0 0.0 GO:0045428 5 regulation of nitric oxide biosynthetic process 33 36 2 2 2 2 2 2 36 34 2475 0.98441 0.099472 0.099472 5.56 363328;25106 ticam1;rgn TICAM1_10015;RGN_9699 781.9784999999999 781.9784999999999 752.835 41.215132955020806 788.8192572347265 40.063640191718896 474.0525 474.0525 458.716 21.689086299333926 477.65238585209 21.0831237771791 2178.8199999999997 2178.8199999999997 1994.77 260.28600615477114 2222.021446945337 253.01398175527828 0.5 781.9784999999999 811.122;752.835 489.389;458.716 2362.87;1994.77 0 2 0 2 363328;25106 TICAM1_10015;RGN_9699 781.9784999999999 781.9784999999999 41.215132955020806 474.0525 474.0525 21.689086299333926 2178.8199999999997 2178.8199999999997 260.28600615477114 811.122;752.835 489.389;458.716 2362.87;1994.77 0 Exp 2,1(0.5);Linear,1(0.5) 1.6258994322931393 3.2564127445220947 1.5415632724761963 1.7148494720458984 0.12253184680178178 1.6282063722610474 724.85724 839.0997599999998 443.99296000000004 504.11204 1818.0819999999999 2539.5579999999995 DOWN 0.0 1.0 0.0 GO:0007186 5 G protein-coupled receptor signaling pathway 111 118 2 2 2 2 2 2 36 116 2393 0.74335 0.53244 0.69509 1.69 60628;54223 cxcr4;adcy4 CXCR4_8411;ADCY4_7988 358.21600000000086 358.21600000000086 1.65461E-12 506.59392545903944 495.60833666119095 467.8505070698923 196.85400000000084 196.85400000000084 1.65461E-12 278.3935966073921 272.3565767724004 257.10254069817205 1043.5400000000009 1043.5400000000009 1.65462E-12 1475.788420878818 1443.7856590420831 1362.9227006825931 1.65461E-12;716.432 1.65461E-12;393.708 1.65462E-12;2087.08 0 2 0 2 60628;54223 CXCR4_8411;ADCY4_7988 358.21600000000086 358.21600000000086 506.59392545903944 196.85400000000084 196.85400000000084 278.3935966073921 1043.5400000000009 1043.5400000000009 1475.788420878818 1.65461E-12;716.432 1.65461E-12;393.708 1.65462E-12;2087.08 0 Exp 2,1(0.5);Hill,1(0.5) 1.6971315490832055 3.3955482244491577 1.6510682106018066 1.744480013847351 0.06605211951778801 1.6977741122245789 -343.88735999999744 1060.319359999999 -188.97983999999752 582.6878399999991 -1001.7983999999974 3088.8783999999987 DOWN 0.0 1.0 0.0 GO:0072347 5 response to anesthetic 42 44 3 3 2 3 2 2 36 42 2467 0.97336 0.13884 0.13884 4.55 24587;60628 nefh;cxcr4 NEFH_33218;CXCR4_8411 2.30309E-12 2.30309E-12 1.65461E-12 9.170892109277046E-13 2.336623374805599E-12 9.158622420147544E-13 2.30309E-12 2.30309E-12 1.65461E-12 9.170892109277046E-13 2.336623374805599E-12 9.158622420147544E-13 2.3030999999999997E-12 2.3030999999999997E-12 1.65462E-12 9.170892109277054E-13 2.336633374805599E-12 9.158622420147552E-13 2.95157E-12;1.65461E-12 2.95157E-12;1.65461E-12 2.95158E-12;1.65462E-12 0 2 0 2 24587;60628 NEFH_33218;CXCR4_8411 2.30309E-12 2.30309E-12 9.170892109277046E-13 2.30309E-12 2.30309E-12 9.170892109277046E-13 2.3030999999999997E-12 2.3030999999999997E-12 9.170892109277054E-13 2.95157E-12;1.65461E-12 2.95157E-12;1.65461E-12 2.95158E-12;1.65462E-12 0 Hill,2(1) 2.0648287817807778 4.188485026359558 1.744480013847351 2.444005012512207 0.49463887016543023 2.094242513179779 1.0320692E-12 3.5741108E-12 1.0320692E-12 3.5741108E-12 1.0320792000000001E-12 3.5741207999999994E-12 DOWN 0.0 1.0 0.0 GO:0001932 8 regulation of protein phosphorylation 371 395 16 12 7 9 4 4 34 391 2118 0.27555 0.86316 0.50221 1.01 89829;25106;361921;60628 socs3;rgn;ect2;cxcr4 SOCS3_32863;RGN_9699;ECT2_8523;CXCR4_8411 398.29772500000047 392.03345 1.65461E-12 442.66364402252646 565.3986545440569 410.49749906098526 240.95387500000044 237.59425000000002 1.65461E-12 269.0805192572084 342.0550570505923 248.8559526510144 1102.1761250000004 1030.98225 1.65462E-12 1242.5299780756711 1597.7294110410583 1173.7031114690421 809.124;752.835;31.2319;1.65461E-12 488.627;458.716;16.4725;1.65461E-12 2346.74;1994.77;67.1945;1.65462E-12 1 3 1 89829 SOCS3_32863 809.124 809.124 488.627 488.627 2346.74 2346.74 809.124 488.627 2346.74 3 25106;361921;60628 RGN_9699;ECT2_8523;CXCR4_8411 261.3556333333339 31.2319 425.9199851952276 158.39616666666723 16.4725 260.21498330050684 687.3215000000006 67.1945 1132.781956212999 752.835;31.2319;1.65461E-12 458.716;16.4725;1.65461E-12 1994.77;67.1945;1.65462E-12 0 Exp 2,1(0.25);Exp 4,1(0.25);Hill,1(0.25);Linear,1(0.25) 1.8299438087157818 7.353551864624023 1.7148494720458984 2.1538212299346924 0.21069727360061657 1.7424405813217163 -35.51264614207548 832.1080961420763 -22.745033872063743 504.6527838720646 -115.50325351415722 2319.8555035141585 DOWN 0.25 0.75 0.0 GO:0000045 7 autophagosome assembly 11 11 1 1 1 1 1 1 37 10 2499 0.98905 0.15268 0.15268 9.09 362246 tp53inp2 TP53INP2_32755 827.265 827.265 827.265 827.265 495.492 495.492 495.492 495.492 2498.6 2498.6 2498.6 2498.6 0.0 827.265 827.265 495.492 2498.6 0 1 0 1 362246 TP53INP2_32755 827.265 827.265 495.492 495.492 2498.6 2498.6 827.265 495.492 2498.6 0 Linear,1(1) 1.5739303827285767 1.5739303827285767 1.5739303827285767 1.5739303827285767 0.0 1.5739303827285767 827.265 827.265 495.492 495.492 2498.6 2498.6 DOWN 0.0 1.0 0.0 GO:0045937 8 positive regulation of phosphate metabolic process 306 327 8 7 5 5 3 3 35 324 2185 0.2615 0.88388 0.46885 0.92 25106;361921;60628 rgn;ect2;cxcr4 RGN_9699;ECT2_8523;CXCR4_8411 261.3556333333339 31.2319 1.65461E-12 425.9199851952276 322.64581660527995 448.6045901644791 158.39616666666723 16.4725 1.65461E-12 260.21498330050684 196.0679622467778 273.85786127129774 687.3215000000006 67.1945 1.65462E-12 1132.781956212999 851.7075076734199 1191.796280546408 752.835;31.2319;1.65461E-12 458.716;16.4725;1.65461E-12 1994.77;67.1945;1.65462E-12 0 3 0 3 25106;361921;60628 RGN_9699;ECT2_8523;CXCR4_8411 261.3556333333339 31.2319 425.9199851952276 158.39616666666723 16.4725 260.21498330050684 687.3215000000006 67.1945 1132.781956212999 752.835;31.2319;1.65461E-12 458.716;16.4725;1.65461E-12 1994.77;67.1945;1.65462E-12 0 Exp 2,1(0.34);Exp 4,1(0.34);Hill,1(0.34) 1.8608036612898595 5.613150715827942 1.7148494720458984 2.1538212299346924 0.2453346029471074 1.744480013847351 -220.61820215385 743.3294688205178 -136.06480701854713 452.8571403518816 -594.5419560113423 1969.1849560113433 DOWN 0.0 1.0 0.0 GO:0032355 5 response to estradiol 114 121 5 5 3 5 3 3 35 118 2391 0.8967 0.26894 0.42407 2.48 89829;24314;24587 socs3;nqo1;nefh SOCS3_32863;NQO1_33055;NEFH_33218 283.22503333333435 40.5511 2.95157E-12 455.8929592389013 333.17586129206455 465.7220687251976 170.07006666666766 21.5832 2.95157E-12 276.0893849129532 199.90073979965254 282.47871355861395 808.698400000001 79.3552 2.95158E-12 1332.5739320726925 949.1693404834747 1367.0278064258484 809.124;40.5511;2.95157E-12 488.627;21.5832;2.95157E-12 2346.74;79.3552;2.95158E-12 2 1 2 89829;24314 SOCS3_32863;NQO1_33055 424.83755 424.83755 543.4631094262103 255.1051 255.1051 330.2498380911337 1213.0475999999999 1213.0475999999999 1603.2831676393037 809.124;40.5511 488.627;21.5832 2346.74;79.3552 1 24587 NEFH_33218 2.95157E-12 2.95157E-12 2.95157E-12 2.95157E-12 2.95158E-12 2.95158E-12 2.95157E-12 2.95157E-12 2.95158E-12 0 Exp 4,1(0.34);Hill,1(0.34);Linear,1(0.34) 2.2221821404291893 6.764214873313904 1.7404011487960815 2.5798087120056152 0.45057483636752343 2.444005012512207 -232.6664152336059 799.1164819002745 -142.35448350512019 482.49461683845544 -699.2509600586038 2316.647760058606 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0048869 3 cellular developmental process 541 573 22 20 17 12 9 9 29 564 1945 0.65609 0.49349 0.84553 1.57 362246;360243;89829;24587;170568;24296;60628;24253;25748 tp53inp2;top2a;socs3;nefh;dmbt1;cyp1a1;cxcr4;cebpb;alas2 TP53INP2_32755;TOP2A_10059;SOCS3_32863;NEFH_33218;DMBT1_32993;CYP1A1_8415;CXCR4_8411;CEBPB_32843,CEBPB_8282;ALAS2_8019 24253(-0.009836) 265.17965888888943 49.0449 1.65461E-12 370.5424398383239 261.7005379212647 369.4830978395421 163.85940444444498 37.2697 1.65461E-12 227.29156132391827 161.05134699057555 224.64331775994387 708.7725422222227 64.8529 1.65462E-12 1054.23477501627 712.204371705871 1074.3040566857576 827.265;12.3342;809.124;2.95157E-12;2.64673;49.0449;1.65461E-12;620.8109999999999;65.3911 495.492;3.46407;488.627;2.95157E-12;1.09657;39.2363;1.65461E-12;409.549;37.2697 2498.6;46.5267;2346.74;2.95158E-12;8.73928;64.8529;1.65462E-12;1279.85;133.644 3 7 3 89829;170568;24296 SOCS3_32863;DMBT1_32993;CYP1A1_8415 286.93854333333337 49.0449 452.8205338878402 176.31995666666668 39.2363 271.13728393163603 806.7773933333333 64.8529 1333.9418304544138 809.124;2.64673;49.0449 488.627;1.09657;39.2363 2346.74;8.73928;64.8529 6 362246;360243;24587;60628;24253;25748 TP53INP2_32755;TOP2A_10059;NEFH_33218;CXCR4_8411;CEBPB_32843,CEBPB_8282;ALAS2_8019 254.30021666666744 38.862649999999995 370.45653057128465 157.62912833333408 20.366885 230.4613126706062 659.7701166666674 90.08535 1028.5196929539854 827.265;12.3342;2.95157E-12;1.65461E-12;620.8109999999999;65.3911 495.492;3.46407;2.95157E-12;1.65461E-12;409.549;37.2697 2498.6;46.5267;2.95158E-12;1.65462E-12;1279.85;133.644 0 Exp 4,1(0.1);Exp 5,1(0.1);Hill,3(0.3);Linear,4(0.4);Poly 2,1(0.1) 2.156025293707182 25.7724392414093 1.5669527053833008 8.822484970092773 2.234626769761827 1.7268086671829224 23.091931527851074 507.26738624992765 15.362251046151641 312.35655784273825 20.005822544926218 1397.5392618995193 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0042098 6 T cell proliferation 19 21 2 2 2 2 2 2 36 19 2490 0.99661 0.038087 0.038087 9.52 499271;60628 itgax;cxcr4 ITGAX_32980;CXCR4_8411 74.15200000000083 74.15200000000083 1.65461E-12 104.86676407708858 115.20733461432921 87.32672676455252 47.59200000000082 47.59200000000082 1.65461E-12 67.30525186045917 73.94200384298692 56.04776108774621 170.49250000000083 170.49250000000083 1.65462E-12 241.11280578289376 264.8881553664566 200.78422649295464 0.5 74.15200000000083 148.304;1.65461E-12 95.184;1.65461E-12 340.985;1.65462E-12 0 2 0 2 499271;60628 ITGAX_32980;CXCR4_8411 74.15200000000083 74.15200000000083 104.86676407708858 47.59200000000082 47.59200000000082 67.30525186045917 170.49250000000083 170.49250000000083 241.11280578289376 148.304;1.65461E-12 95.184;1.65461E-12 340.985;1.65462E-12 0 Hill,1(0.5);Poly 2,1(0.5) 1.8048420714751157 3.6117727756500244 1.744480013847351 1.8672927618026733 0.08684172689536267 1.8058863878250122 -71.18591999999755 219.4899199999992 -45.68831999999756 140.8723199999992 -163.67279999999752 504.65779999999916 DOWN 0.0 1.0 0.0 GO:0051188 5 cofactor biosynthetic process 48 53 4 4 4 4 4 4 34 49 2460 0.99904 0.0073089 0.0073089 7.55 25106;60671;24296;25748 rgn;gulo;cyp1a1;alas2 RGN_9699;GULO_8772;CYP1A1_8415;ALAS2_8019 265.315 129.69004999999999 49.0449 331.41387549971415 158.5102087293803 261.35901044130463 161.874 75.75515 37.2697 200.9490565655717 99.17412182790906 157.3263156692124 808.274225 586.737 64.8529 907.2286569505704 446.359551756576 759.0800351720235 1.5 129.69004999999999 752.835;193.989;49.0449;65.3911 458.716;112.274;39.2363;37.2697 1994.77;1039.83;64.8529;133.644 2 2 2 60671;24296 GULO_8772;CYP1A1_8415 121.51695000000001 121.51695000000001 102.49095600298105 75.75515 75.75515 51.64545295226869 552.34145 552.34145 689.4129189115946 193.989;49.0449 112.274;39.2363 1039.83;64.8529 2 25106;25748 RGN_9699;ALAS2_8019 409.11305000000004 409.11305000000004 486.0962433753269 247.99285 247.99285 298.0075366359801 1064.2069999999999 1064.2069999999999 1316.0148152425945 752.835;65.3911 458.716;37.2697 1994.77;133.644 0 Exp 2,1(0.25);Exp 5,1(0.25);Poly 2,2(0.5) 2.532012942414847 13.836300134658813 1.5857495069503784 8.822484970092773 3.5761180350808095 1.7140328288078308 -59.470597989719806 590.10059798972 -35.05607543426021 358.80407543426026 -80.80985881155902 1697.3583088115588 CONFLICT 0.5 0.5 0.0 GO:0010243 5 response to organonitrogen compound 400 420 15 13 11 12 9 9 29 411 2098 0.91749 0.16146 0.2668 2.14 24522;363328;89829;25044;24587;24450;60628;24253;25612 zfp354a;ticam1;socs3;sds;nefh;hmgcs2;cxcr4;cebpb;asns ZFP354A_10203;TICAM1_10015;SOCS3_32863;SDS_9798;NEFH_33218;HMGCS2_8812;CXCR4_8411;CEBPB_32843,CEBPB_8282;ASNS_8091 24253(-0.009836) 350.8974000000005 157.765 1.65461E-12 343.2298939082078 376.389185079149 345.48482287365545 221.72684444444496 99.5663 1.65461E-12 213.472544973212 234.31675956222105 213.55105592458196 863.1337777777783 371.219 1.65462E-12 955.5038068363168 955.4255730515796 994.840448380408 99.2226;811.122;809.124;553.681;2.95157E-12;106.351;1.65461E-12;620.8109999999999;157.765 71.0566;489.389;488.627;377.484;2.95157E-12;59.8697;1.65461E-12;409.549;99.5663 163.536;2362.87;2346.74;1035.66;2.95158E-12;208.329;1.65462E-12;1279.85;371.219 3 7 3 89829;25044;25612 SOCS3_32863;SDS_9798;ASNS_8091 506.85666666666674 553.681 328.19434084751265 321.8924333333334 377.484 200.39928588810722 1251.2063333333333 1035.66 1005.2442348605306 809.124;553.681;157.765 488.627;377.484;99.5663 2346.74;1035.66;371.219 6 24522;363328;24587;24450;60628;24253 ZFP354A_10203;TICAM1_10015;NEFH_33218;HMGCS2_8812;CXCR4_8411;CEBPB_32843,CEBPB_8282 272.91776666666743 102.7868 351.4473536627729 171.6440500000008 65.46315 218.67570450383067 669.0975000000008 185.9325 959.7048366971475 99.2226;811.122;2.95157E-12;106.351;1.65461E-12;620.8109999999999 71.0566;489.389;2.95157E-12;59.8697;1.65461E-12;409.549 163.536;2362.87;2.95158E-12;208.329;1.65462E-12;1279.85 0 Exp 4,1(0.1);Hill,2(0.2);Linear,5(0.5);Poly 2,2(0.2) 1.796524148673585 18.266276359558105 1.5415632724761963 2.578549861907959 0.3747746078706703 1.7060840725898743 126.6538693133048 575.1409306866964 82.25811506194646 361.1955738269435 238.87129064471787 1487.3962649108385 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0051336 5 regulation of hydrolase activity 294 317 7 6 6 5 4 4 34 313 2196 0.47932 0.71479 1.0 1.26 299276;25106;83928;361921 serpina3m;rgn;fetub;ect2 SERPINA3M_9809;RGN_9699;FETUB_33027;ECT2_8523 449.206975 506.3805 31.2319 303.6195561603411 504.6335597619176 187.4528183789485 288.36962500000004 339.145 16.4725 193.04876775371844 329.39781886428227 120.72334496888526 989.331375 947.6805 67.1945 788.7516705667862 1035.324132178669 528.6326018219464 466.86;752.835;545.901;31.2319 296.126;458.716;382.164;16.4725 918.743;1994.77;976.618;67.1945 1 3 1 83928 FETUB_33027 545.901 545.901 382.164 382.164 976.618 976.618 545.901 382.164 976.618 3 299276;25106;361921 SERPINA3M_9809;RGN_9699;ECT2_8523 416.9756333333333 466.86 363.37872256187956 257.1048333333333 296.126 223.68910771220695 993.5691666666667 918.743 965.9637899339618 466.86;752.835;31.2319 296.126;458.716;16.4725 918.743;1994.77;67.1945 0 Exp 2,3(0.75);Exp 4,1(0.25) 1.726780933478392 6.9731152057647705 1.5054508447647095 2.1538212299346924 0.2867831071639183 1.6569215655326843 151.65980996286578 746.7541400371343 99.18183260135586 477.55741739864425 216.35473784454973 1762.3080121554503 DOWN 0.25 0.75 0.0 GO:0030162 7 regulation of proteolysis 214 230 10 9 6 7 4 4 34 226 2283 0.74458 0.4535 0.77232 1.74 360772;299276;25106;83928 zfand2a;serpina3m;rgn;fetub ZFAND2A_10197;SERPINA3M_9809;RGN_9699;FETUB_33027 677.90825 649.3679999999999 466.86 215.61873938563446 653.6862270489067 230.5600118187635 456.15574999999995 420.44 296.126 167.9932191932659 446.37614375730266 182.5106816014707 1295.5527499999998 1134.349 918.743 494.1733114143766 1160.7624566432983 388.61675453247756 946.037;466.86;752.835;545.901 687.617;296.126;458.716;382.164 1292.08;918.743;1994.77;976.618 2 2 2 360772;83928 ZFAND2A_10197;FETUB_33027 745.969 745.969 282.93887899686 534.8905 534.8905 215.98788763377436 1134.349 1134.349 223.06531940667136 946.037;545.901 687.617;382.164 1292.08;976.618 2 299276;25106 SERPINA3M_9809;RGN_9699 609.8475000000001 609.8475000000001 202.21486174982272 377.421 377.421 114.96849155312071 1456.7565 1456.7565 760.8659884398173 466.86;752.835 296.126;458.716 918.743;1994.77 0 Exp 2,3(0.75);Poly 2,1(0.25) 1.8019520608681594 7.373368740081787 1.5054508447647095 2.554074764251709 0.4815004106772047 1.6569215655326843 466.6018854020785 889.2146145979214 291.52239519059947 620.7891048094006 811.2629048139113 1779.8425951860884 CONFLICT 0.5 0.5 0.0 GO:0090304 5 nucleic acid metabolic process 251 278 9 8 6 4 3 3 35 275 2234 0.3911 0.80151 0.79263 1.08 360243;114519;291885 top2a;nfil3;mcm5 TOP2A_10059;NFIL3_9304;MCM5_9209 48.7186 12.5006 12.3342 62.875577822871726 64.39683658071353 66.65714171710334 31.8969 9.67503 3.46407 43.978039748241386 41.75032946450017 47.819836608489545 104.13409999999999 46.5267 36.0856 108.94635398171891 133.17952467679262 113.17956123301558 12.3342;121.321;12.5006 3.46407;82.5516;9.67503 46.5267;229.79;36.0856 0 3 0 3 360243;114519;291885 TOP2A_10059;NFIL3_9304;MCM5_9209 48.7186 12.5006 62.875577822871726 31.8969 9.67503 43.978039748241386 104.13409999999999 46.5267 108.94635398171891 12.3342;121.321;12.5006 3.46407;82.5516;9.67503 46.5267;229.79;36.0856 0 Exp 5,1(0.34);Hill,1(0.34);Poly 2,1(0.34) 2.218099159521777 6.7809600830078125 1.7765510082244873 2.846071243286133 0.5420042984641723 2.1583378314971924 -22.431814291716982 119.86901429171698 -17.868936850675283 81.66273685067527 -19.1503053252044 227.41850532520436 DOWN 0.0 1.0 0.0 GO:0009266 4 response to temperature stimulus 80 87 5 5 4 4 3 3 35 84 2425 0.96129 0.13828 0.13828 3.45 89829;24450;60628 socs3;hmgcs2;cxcr4 SOCS3_32863;HMGCS2_8812;CXCR4_8411 305.1583333333339 106.351 1.65461E-12 439.6745144812613 344.7728313379894 428.3881006754941 182.83223333333387 59.8697 1.65461E-12 266.5125226608743 206.0071946624545 260.5456769454786 851.6896666666671 208.329 1.65462E-12 1298.934897314077 949.387250692828 1285.4633649978434 809.124;106.351;1.65461E-12 488.627;59.8697;1.65461E-12 2346.74;208.329;1.65462E-12 1 2 1 89829 SOCS3_32863 809.124 809.124 488.627 488.627 2346.74 2346.74 809.124 488.627 2346.74 2 24450;60628 HMGCS2_8812;CXCR4_8411 53.175500000000824 53.175500000000824 75.20151328596936 29.93485000000083 29.93485000000083 42.33427085760307 104.16450000000083 104.16450000000083 147.3108486178111 106.351;1.65461E-12 59.8697;1.65461E-12 208.329;1.65462E-12 0 Exp 4,1(0.34);Hill,1(0.34);Linear,1(0.34) 1.9856237759383282 6.063431024551392 1.7404011487960815 2.578549861907959 0.48273222630409507 1.744480013847351 -192.38021727815158 802.6968839448193 -118.7550769999637 484.41954366663145 -618.1935420765321 2321.5728754098664 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0009653 3 anatomical structure morphogenesis 282 299 5 5 4 4 4 4 34 295 2214 0.53358 0.66853 1.0 1.34 89829;24587;361921;60628 socs3;nefh;ect2;cxcr4 SOCS3_32863;NEFH_33218;ECT2_8523;CXCR4_8411 210.08897500000117 15.615950000001476 1.65461E-12 399.6279808719628 407.9748347464169 463.5363876773687 126.27487500000116 8.236250000001476 1.65461E-12 241.69285754181647 246.12782333898656 280.1963608033876 603.4836250000011 33.59725000000148 1.65462E-12 1162.6025095817977 1180.8527231385856 1347.0565105613543 809.124;2.95157E-12;31.2319;1.65461E-12 488.627;2.95157E-12;16.4725;1.65461E-12 2346.74;2.95158E-12;67.1945;1.65462E-12 1 3 1 89829 SOCS3_32863 809.124 809.124 488.627 488.627 2346.74 2346.74 809.124 488.627 2346.74 3 24587;361921;60628 NEFH_33218;ECT2_8523;CXCR4_8411 10.41063333333487 2.95157E-12 18.031745872302142 5.490833333334869 2.95157E-12 9.510402309224782 22.398166666668203 2.95158E-12 38.79476266306098 2.95157E-12;31.2319;1.65461E-12 2.95157E-12;16.4725;1.65461E-12 2.95158E-12;67.1945;1.65462E-12 0 Exp 4,1(0.25);Hill,2(0.5);Linear,1(0.25) 1.9994326343401825 8.082707405090332 1.7404011487960815 2.444005012512207 0.3424292238649405 1.9491506218910217 -181.54644625452235 601.7243962545247 -110.58412539097894 363.13387539098125 -535.8668343901605 1742.8340843901628 DOWN 0.25 0.75 0.0 GO:0045666 8 positive regulation of neuron differentiation 97 102 2 2 2 2 2 2 36 100 2409 0.8069 0.45421 0.66335 1.96 361921;60628 ect2;cxcr4 ECT2_8523;CXCR4_8411 15.615950000000828 15.615950000000828 1.65461E-12 22.084288279338963 11.074555702567883 21.129771992982683 8.236250000000828 8.236250000000828 1.65461E-12 11.647816453094235 5.841002910824038 11.144380237974339 33.59725000000083 33.59725000000083 1.65462E-12 47.5136866084383 23.8265758137084 45.460073328312255 31.2319;1.65461E-12 16.4725;1.65461E-12 67.1945;1.65462E-12 0 2 0 2 361921;60628 ECT2_8523;CXCR4_8411 15.615950000000828 15.615950000000828 22.084288279338963 8.236250000000828 8.236250000000828 11.647816453094235 33.59725000000083 33.59725000000083 47.5136866084383 31.2319;1.65461E-12 16.4725;1.65461E-12 67.1945;1.65462E-12 0 Exp 4,1(0.5);Hill,1(0.5) 1.9383751156629077 3.8983012437820435 1.744480013847351 2.1538212299346924 0.28944794971450694 1.9491506218910217 -14.991311999997547 46.2232119999992 -7.906799999997547 24.379299999999205 -32.253359999997556 99.44785999999921 DOWN 0.0 1.0 0.0 GO:0001933 9 negative regulation of protein phosphorylation 121 130 9 7 4 5 2 2 36 128 2381 0.69377 0.58616 1.0 1.54 89829;25106 socs3;rgn SOCS3_32863;RGN_9699 780.9795 780.9795 752.835 39.802333606208904 792.4270244933348 36.36116233633102 473.67150000000004 473.67150000000004 458.716 21.150270932069965 479.7545163108269 19.32169210045054 2170.755 2170.755 1994.77 248.88037377422467 2242.3353300097533 227.36304264632463 809.124;752.835 488.627;458.716 2346.74;1994.77 1 1 1 89829 SOCS3_32863 809.124 809.124 488.627 488.627 2346.74 2346.74 809.124 488.627 2346.74 1 25106 RGN_9699 752.835 752.835 458.716 458.716 1994.77 1994.77 752.835 458.716 1994.77 0 Exp 2,1(0.5);Linear,1(0.5) 1.7275780709308148 3.45525062084198 1.7148494720458984 1.7404011487960815 0.018067763900741118 1.72762531042099 725.81628 836.14272 444.35872000000006 502.98428 1825.8244000000004 2515.6856 CONFLICT 0.5 0.5 0.0 GO:0045931 7 positive regulation of mitotic cell cycle 58 63 4 4 4 2 2 2 36 61 2448 0.93411 0.24161 0.24161 3.17 24296;25612 cyp1a1;asns CYP1A1_8415;ASNS_8091 103.40494999999999 103.40494999999999 49.0449 76.87671996127956 84.23102784853232 71.93574556966732 69.40129999999999 69.40129999999999 39.2363 42.65975210898442 58.76147605393993 39.917950132662035 218.03595 218.03595 64.8529 216.6335468356759 164.00509690798887 202.71020557165838 49.0449;157.765 39.2363;99.5663 64.8529;371.219 2 0 2 24296;25612 CYP1A1_8415;ASNS_8091 103.40494999999999 103.40494999999999 76.87671996127956 69.40129999999999 69.40129999999999 42.65975210898442 218.03595 218.03595 216.6335468356759 49.0449;157.765 39.2363;99.5663 64.8529;371.219 0 0 Poly 2,2(1) 3.7568508700022845 10.422252893447876 1.5997679233551025 8.822484970092773 5.107232202339881 5.211126446723938 -3.140748000000002 209.95064799999997 10.27790000000001 128.52469999999997 -82.20282799999993 518.2747279999999 UP 1.0 0.0 0.0 GO:0007271 8 synaptic transmission, cholinergic 4 4 1 1 1 1 1 1 37 3 2506 0.99872 0.058389 0.058389 25.0 170945 chrna2 CHRNA2_32401 592.031 592.031 592.031 592.031 396.105 396.105 396.105 396.105 1168.63 1168.63 1168.63 1168.63 0.0 592.031 0.0 592.031 592.031 396.105 1168.63 0 1 0 1 170945 CHRNA2_32401 592.031 592.031 396.105 396.105 1168.63 1168.63 592.031 396.105 1168.63 0 Linear,1(1) 1.8731646537780762 1.8731646537780762 1.8731646537780762 1.8731646537780762 0.0 1.8731646537780762 592.031 592.031 396.105 396.105 1168.63 1168.63 DOWN 0.0 1.0 0.0 GO:0009636 4 response to toxic substance 240 257 13 12 11 9 7 7 31 250 2259 0.96777 0.081487 0.098511 2.72 24314;24587;24450;361921;24296;170945;25612 nqo1;nefh;hmgcs2;ect2;cyp1a1;chrna2;asns NQO1_33055;NEFH_33218;HMGCS2_8812;ECT2_8523;CYP1A1_8415;CHRNA2_32401;ASNS_8091 139.56784285714326 49.0449 2.95157E-12 206.3055911236437 91.54552528625976 116.83518592083365 90.40471428571472 39.2363 2.95157E-12 138.721891182435 58.11634670665235 77.50779902566208 279.9400857142861 79.3552 2.95158E-12 410.9650595873181 179.46378980643428 240.95168236745758 40.5511;2.95157E-12;106.351;31.2319;49.0449;592.031;157.765 21.5832;2.95157E-12;59.8697;16.4725;39.2363;396.105;99.5663 79.3552;2.95158E-12;208.329;67.1945;64.8529;1168.63;371.219 3 4 3 24314;24296;25612 NQO1_33055;CYP1A1_8415;ASNS_8091 82.45366666666666 49.0449 65.3596500598292 53.46193333333334 39.2363 40.89153279351768 171.80903333333333 79.3552 172.8462619810545 40.5511;49.0449;157.765 21.5832;39.2363;99.5663 79.3552;64.8529;371.219 4 24587;24450;361921;170945 NEFH_33218;HMGCS2_8812;ECT2_8523;CHRNA2_32401 182.40347500000073 68.79145 276.7083669204254 118.11180000000074 38.1711 187.04126644707696 361.03837500000077 137.76175 545.349220555259 2.95157E-12;106.351;31.2319;592.031 2.95157E-12;59.8697;16.4725;396.105 2.95158E-12;208.329;67.1945;1168.63 0 Exp 4,3(0.43);Hill,1(0.15);Linear,1(0.15);Poly 2,2(0.29) 2.6532948954235924 22.051602363586426 1.5997679233551025 8.822484970092773 2.5282763493293894 2.444005012512207 -13.26547783755069 292.4011635518372 -12.36190084568564 193.17132941711503 -24.507090943081437 584.3872623716536 CONFLICT 0.42857142857142855 0.5714285714285714 0.0 GO:0032269 7 negative regulation of cellular protein metabolic process 274 292 13 11 8 7 4 4 34 288 2221 0.55509 0.64931 1.0 1.37 89829;299276;25106;83928 socs3;serpina3m;rgn;fetub SOCS3_32863;SERPINA3M_9809;RGN_9699;FETUB_33027 643.6800000000001 649.3679999999999 466.86 163.41417360192443 614.3230921467289 168.46003354594728 406.40824999999995 420.44 296.126 86.11229467919624 390.4389261733686 91.21238215433287 1559.21775 1485.694 918.743 721.001024227832 1447.4583684608597 739.910669127054 809.124;466.86;752.835;545.901 488.627;296.126;458.716;382.164 2346.74;918.743;1994.77;976.618 2 2 2 89829;83928 SOCS3_32863;FETUB_33027 677.5125 677.5125 186.12676826426633 435.39549999999997 435.39549999999997 75.28070924546384 1661.6789999999999 1661.6789999999999 968.8225572528748 809.124;545.901 488.627;382.164 2346.74;976.618 2 299276;25106 SERPINA3M_9809;RGN_9699 609.8475000000001 609.8475000000001 202.21486174982272 377.421 377.421 114.96849155312071 1456.7565 1456.7565 760.8659884398173 466.86;752.835 296.126;458.716 918.743;1994.77 0 Exp 2,3(0.75);Linear,1(0.25) 1.6371827935196284 6.55969512462616 1.5054508447647095 1.7404011487960815 0.10873178940710951 1.6569215655326843 483.53410987011375 803.8258901298864 322.018201214388 490.798298785612 852.6367462567241 2265.7987537432755 CONFLICT 0.5 0.5 0.0 GO:0009150 7 purine ribonucleotide metabolic process 68 80 2 2 2 2 2 2 36 78 2431 0.88507 0.33659 0.33659 2.5 24450;54223 hmgcs2;adcy4 HMGCS2_8812;ADCY4_7988 411.3915 411.3915 106.351 431.3924121730702 335.2934414889971 417.7530182562563 226.78885000000002 226.78885000000002 59.8697 236.059325749789 185.14774580791118 228.59580520379683 1147.7045 1147.7045 208.329 1328.477572261007 913.3597104956468 1286.474912023091 106.351;716.432 59.8697;393.708 208.329;2087.08 0 2 0 2 24450;54223 HMGCS2_8812;ADCY4_7988 411.3915 411.3915 431.3924121730702 226.78885000000002 226.78885000000002 236.059325749789 1147.7045 1147.7045 1328.477572261007 106.351;716.432 59.8697;393.708 208.329;2087.08 0 Exp 2,1(0.5);Exp 4,1(0.5) 2.0633375163670897 4.229618072509766 1.6510682106018066 2.578549861907959 0.6558285650646772 2.114809036254883 -186.48787999999996 1009.27088 -100.37268399999996 553.950384 -693.4714799999997 2988.88048 DOWN 0.0 1.0 0.0 GO:0061024 5 membrane organization 110 116 3 3 2 3 2 2 36 114 2395 0.7515 0.52306 0.69092 1.72 361308;60628 kif20a;cxcr4 KIF20A_8961;CXCR4_8411 17.63735000000083 17.63735000000083 1.65461E-12 24.942979574319942 13.625230120786119 24.28905140581991 7.773000000000827 7.773000000000827 1.65461E-12 10.992682020324898 6.004808756920996 10.704487725050923 48.272050000000824 48.272050000000824 1.65462E-12 68.266987793551 37.291191117263224 66.4772374486158 35.2747;1.65461E-12 15.546;1.65461E-12 96.5441;1.65462E-12 0 2 0 2 361308;60628 KIF20A_8961;CXCR4_8411 17.63735000000083 17.63735000000083 24.942979574319942 7.773000000000827 7.773000000000827 10.992682020324898 48.272050000000824 48.272050000000824 68.266987793551 35.2747;1.65461E-12 15.546;1.65461E-12 96.5441;1.65462E-12 0 Exp 4,1(0.5);Hill,1(0.5) 1.7609797055569367 3.522115468978882 1.744480013847351 1.7776354551315308 0.02344443736527587 1.761057734489441 -16.931855999997545 52.2065559999992 -7.46207999999755 23.008079999999204 -46.34116799999756 142.8852679999992 DOWN 0.0 1.0 0.0 GO:0044093 4 positive regulation of molecular function 417 443 11 10 7 7 4 4 34 439 2070 0.18342 0.91805 0.38628 0.9 363328;25106;361921;24253 ticam1;rgn;ect2;cebpb TICAM1_10015;RGN_9699;ECT2_8523;CEBPB_32843,CEBPB_8282 24253(-0.009836) 553.999975 686.823 31.2319 357.4899887678012 654.8267856906807 269.5189695849185 343.53162499999996 434.1325 16.4725 220.50531296221078 406.2790899702578 163.16390518928227 1426.1711249999998 1637.31 67.1945 1011.4242107040923 1702.3875074355585 838.8605161082683 811.122;752.835;31.2319;620.8109999999999 489.389;458.716;16.4725;409.549 2362.87;1994.77;67.1945;1279.85 0 5 0 4 363328;25106;361921;24253 TICAM1_10015;RGN_9699;ECT2_8523;CEBPB_32843,CEBPB_8282 553.999975 686.823 357.4899887678012 343.53162499999996 434.1325 220.50531296221078 1426.1711249999998 1637.31 1011.4242107040923 811.122;752.835;31.2319;620.8109999999999 489.389;458.716;16.4725;409.549 2362.87;1994.77;67.1945;1279.85 0 Exp 2,1(0.2);Exp 4,1(0.2);Linear,3(0.6) 1.716823817426697 8.648953676223755 1.5415632724761963 2.1538212299346924 0.24765785761501655 1.671766996383667 203.65978600755494 904.340163992445 127.4364182970335 559.6268317029666 434.97539850998965 2417.36685149001 DOWN 0.0 1.0 0.0 GO:0046483 4 heterocycle metabolic process 413 462 14 13 11 9 8 8 30 454 2055 0.75963 0.38277 0.67048 1.73 360243;114519;291885;24450;24296;25748;26760;54223 top2a;nfil3;mcm5;hmgcs2;cyp1a1;alas2;akr7a3;adcy4 TOP2A_10059;NFIL3_9304;MCM5_9209;HMGCS2_8812;CYP1A1_8415;ALAS2_8019;AKR7A3_8015;ADCY4_7988 143.27125 64.09315 12.3342 234.8324494070978 137.04592146781263 214.9438460462128 84.315425 43.99265 3.46407 127.58358522074339 81.61649492295325 116.47746846437825 361.7444 110.6455 36.0856 700.8617933468746 332.2764925575697 645.7307662819284 12.3342;121.321;12.5006;106.351;49.0449;65.3911;62.7952;716.432 3.46407;82.5516;9.67503;59.8697;39.2363;37.2697;48.749;393.708 46.5267;229.79;36.0856;208.329;64.8529;133.644;87.647;2087.08 2 6 2 24296;26760 CYP1A1_8415;AKR7A3_8015 55.92005 55.92005 9.722930373349357 43.99265 43.99265 6.726494677393277 76.24995000000001 76.24995000000001 16.117862681044187 49.0449;62.7952 39.2363;48.749 64.8529;87.647 6 360243;114519;291885;24450;25748;54223 TOP2A_10059;NFIL3_9304;MCM5_9209;HMGCS2_8812;ALAS2_8019;ADCY4_7988 172.38831666666667 85.87105 270.4004933339466 97.75635 48.5697 148.02834163583054 456.9092166666667 170.9865 802.6006195073073 12.3342;121.321;12.5006;106.351;65.3911;716.432 3.46407;82.5516;9.67503;59.8697;37.2697;393.708 46.5267;229.79;36.0856;208.329;133.644;2087.08 0 Exp 2,1(0.13);Exp 4,1(0.13);Exp 5,2(0.25);Hill,1(0.13);Poly 2,3(0.38) 2.4428017709833543 23.35186994075775 1.6510682106018066 8.822484970092773 2.4247946121956865 1.9819642305374146 -19.459335070037582 306.0018350700376 -4.095488912125816 172.7263389121258 -123.92804421513688 847.4168442151368 DOWN 0.25 0.75 0.0 GO:0051050 5 positive regulation of transport 286 308 6 5 5 5 4 4 34 304 2205 0.50624 0.69223 1.0 1.3 25106;361921;60628;24253 rgn;ect2;cxcr4;cebpb RGN_9699;ECT2_8523;CXCR4_8411;CEBPB_32843,CEBPB_8282 24253(-0.009836) 351.21947500000044 326.02144999999996 1.65461E-12 391.4595713678516 428.96303564727987 377.22091027116556 221.18437500000041 213.01075 1.65461E-12 246.80085381854383 272.18922494322146 238.4019561674752 835.4536250000003 673.52225 1.65462E-12 971.2032808373478 1004.3709361113856 931.901394650473 752.835;31.2319;1.65461E-12;620.8109999999999 458.716;16.4725;1.65461E-12;409.549 1994.77;67.1945;1.65462E-12;1279.85 0 5 0 4 25106;361921;60628;24253 RGN_9699;ECT2_8523;CXCR4_8411;CEBPB_32843,CEBPB_8282 351.21947500000044 326.02144999999996 391.4595713678516 221.18437500000041 213.01075 246.80085381854383 835.4536250000003 673.52225 971.2032808373478 752.835;31.2319;1.65461E-12;620.8109999999999 458.716;16.4725;1.65461E-12;409.549 1994.77;67.1945;1.65462E-12;1279.85 0 Exp 2,1(0.2);Exp 4,1(0.2);Hill,1(0.2);Linear,2(0.4) 1.7598135540213258 8.85187041759491 1.5669527053833008 2.1538212299346924 0.22466019570324358 1.7148494720458984 -32.410904940494106 734.849854940495 -20.680461742172554 463.0492117421734 -116.32559022060059 1787.2328402206012 DOWN 0.0 1.0 0.0 GO:0010941 5 regulation of cell death 479 511 18 17 15 12 10 10 28 501 2008 0.87772 0.21701 0.31229 1.96 360243;89829;25106;24314;316351;24567;361921;60628;24253;25612 top2a;socs3;rgn;nqo1;npas2;mt1;ect2;cxcr4;cebpb;asns TOP2A_10059;SOCS3_32863;RGN_9699;NQO1_33055;NPAS2_9350;MT1A_9255;ECT2_8523;CXCR4_8411;CEBPB_32843,CEBPB_8282;ASNS_8091 24253(-0.009836) 274.8268200000001 156.3965 1.65461E-12 321.74317189341764 267.6332051796753 314.1138107440828 169.95650700000016 98.79965 1.65461E-12 199.73634847794673 164.68448549104252 193.99427305080116 777.7300400000001 376.957 1.65462E-12 871.4271848023002 797.7029632016763 876.4352248216414 12.3342;809.124;752.835;40.5511;155.028;168.588;31.2319;1.65461E-12;620.8109999999999;157.765 3.46407;488.627;458.716;21.5832;98.033;103.554;16.4725;1.65461E-12;409.549;99.5663 46.5267;2346.74;1994.77;79.3552;382.695;1208.95;67.1945;1.65462E-12;1279.85;371.219 3 8 3 89829;24314;25612 SOCS3_32863;NQO1_33055;ASNS_8091 335.8133666666667 157.765 414.06761683099944 203.25883333333334 99.5663 250.1930931928844 932.4380666666666 371.219 1233.4843284008164 809.124;40.5511;157.765 488.627;21.5832;99.5663 2346.74;79.3552;371.219 7 360243;25106;316351;24567;361921;60628;24253 TOP2A_10059;RGN_9699;NPAS2_9350;MT1A_9255;ECT2_8523;CXCR4_8411;CEBPB_32843,CEBPB_8282 248.6897285714288 155.028 308.983258948532 155.68408142857166 98.033 195.40780546820878 711.4266000000001 382.695 784.105023286126 12.3342;752.835;155.028;168.588;31.2319;1.65461E-12;620.8109999999999 3.46407;458.716;98.033;103.554;16.4725;1.65461E-12;409.549 46.5267;1994.77;382.695;1208.95;67.1945;1.65462E-12;1279.85 0 Exp 2,1(0.1);Exp 4,2(0.19);Hill,2(0.19);Linear,3(0.28);Poly 2,3(0.28) 1.8925360483085307 21.249353885650635 1.563178539276123 2.846071243286133 0.43466866004050414 1.7404011487960815 75.40833602110743 474.24530397889293 46.15863562777841 293.75437837222205 237.61387508310793 1317.846204916892 DOWN 0.3 0.7 0.0 GO:0006725 4 cellular aromatic compound metabolic process 429 482 13 12 10 8 7 7 31 475 2034 0.56764 0.59794 1.0 1.45 360243;114519;291885;24450;24296;25748;54223 top2a;nfil3;mcm5;hmgcs2;cyp1a1;alas2;adcy4 TOP2A_10059;NFIL3_9304;MCM5_9209;HMGCS2_8812;CYP1A1_8415;ALAS2_8019;ADCY4_7988 154.76782857142857 65.3911 12.3342 251.20455184510968 147.93044297001887 230.20865222773259 89.39634285714286 39.2363 3.46407 136.92900706404578 86.43458891773848 125.17208774484432 400.90117142857144 133.644 36.0856 747.5056989399316 368.1370864909355 690.1575846989488 12.3342;121.321;12.5006;106.351;49.0449;65.3911;716.432 3.46407;82.5516;9.67503;59.8697;39.2363;37.2697;393.708 46.5267;229.79;36.0856;208.329;64.8529;133.644;2087.08 1 6 1 24296 CYP1A1_8415 49.0449 49.0449 39.2363 39.2363 64.8529 64.8529 49.0449 39.2363 64.8529 6 360243;114519;291885;24450;25748;54223 TOP2A_10059;NFIL3_9304;MCM5_9209;HMGCS2_8812;ALAS2_8019;ADCY4_7988 172.38831666666667 85.87105 270.4004933339466 97.75635 48.5697 148.02834163583054 456.9092166666667 170.9865 802.6006195073073 12.3342;121.321;12.5006;106.351;65.3911;716.432 3.46407;82.5516;9.67503;59.8697;37.2697;393.708 46.5267;229.79;36.0856;208.329;133.644;2087.08 0 Exp 2,1(0.15);Exp 4,1(0.15);Exp 5,2(0.29);Hill,1(0.15);Poly 2,2(0.29) 2.5505916350084443 21.546279311180115 1.6510682106018066 8.822484970092773 2.573605322085552 2.1583378314971924 -31.327107697657112 340.8627648405143 -12.042085132349214 190.8347708466349 -152.85879981103017 954.6611426681729 DOWN 0.14285714285714285 0.8571428571428571 0.0 GO:0007154 3 cell communication 162 169 6 6 4 3 2 2 36 167 2342 0.53287 0.72986 1.0 1.18 170945;25612 chrna2;asns CHRNA2_32401;ASNS_8091 374.89799999999997 374.89799999999997 157.765 307.0724334387573 254.56051234668845 255.59979950809466 247.83565000000002 247.83565000000002 99.5663 209.68452565424323 165.66315169255927 174.5364183850245 769.9245000000001 769.9245000000001 371.219 563.8547254927461 548.957543417825 469.339279901142 592.031;157.765 396.105;99.5663 1168.63;371.219 1 1 1 25612 ASNS_8091 157.765 157.765 99.5663 99.5663 371.219 371.219 157.765 99.5663 371.219 1 170945 CHRNA2_32401 592.031 592.031 396.105 396.105 1168.63 1168.63 592.031 396.105 1168.63 0 Linear,1(0.5);Poly 2,1(0.5) 1.7310773316858876 3.4729325771331787 1.5997679233551025 1.8731646537780762 0.19332068203631514 1.7364662885665894 -50.682680000000005 800.4786799999999 -42.77227599999995 538.443576 -11.538279999999872 1551.38728 CONFLICT 0.5 0.5 0.0 GO:0030154 4 cell differentiation 405 432 13 12 11 9 8 8 30 424 2085 0.81752 0.31007 0.51227 1.85 362246;360243;89829;170568;24296;60628;24253;25748 tp53inp2;top2a;socs3;dmbt1;cyp1a1;cxcr4;cebpb;alas2 TP53INP2_32755;TOP2A_10059;SOCS3_32863;DMBT1_32993;CYP1A1_8415;CXCR4_8411;CEBPB_32843,CEBPB_8282;ALAS2_8019 24253(-0.009836) 298.3271162500002 57.217999999999996 1.65461E-12 381.5950199671718 276.37964533602917 376.59942432782094 184.34183000000021 38.253 1.65461E-12 233.93695375174357 170.0849165833075 228.87819757040623 797.3691100000001 99.24845 1.65462E-12 1090.618065636223 752.1527973246242 1097.2114765403057 827.265;12.3342;809.124;2.64673;49.0449;1.65461E-12;620.8109999999999;65.3911 495.492;3.46407;488.627;1.09657;39.2363;1.65461E-12;409.549;37.2697 2498.6;46.5267;2346.74;8.73928;64.8529;1.65462E-12;1279.85;133.644 3 6 3 89829;170568;24296 SOCS3_32863;DMBT1_32993;CYP1A1_8415 286.93854333333337 49.0449 452.8205338878402 176.31995666666668 39.2363 271.13728393163603 806.7773933333333 64.8529 1333.9418304544138 809.124;2.64673;49.0449 488.627;1.09657;39.2363 2346.74;8.73928;64.8529 5 362246;360243;60628;24253;25748 TP53INP2_32755;TOP2A_10059;CXCR4_8411;CEBPB_32843,CEBPB_8282;ALAS2_8019 305.1602600000003 65.3911 390.0602148958898 189.15495400000032 37.2697 242.76828081029433 791.7241400000003 133.644 1091.6624782590989 827.265;12.3342;1.65461E-12;620.8109999999999;65.3911 495.492;3.46407;1.65461E-12;409.549;37.2697 2498.6;46.5267;1.65462E-12;1279.85;133.644 0 Exp 4,1(0.12);Exp 5,1(0.12);Hill,2(0.23);Linear,4(0.45);Poly 2,1(0.12) 2.126199672902114 23.328434228897095 1.5669527053833008 8.822484970092773 2.3696594186111732 1.7132161855697632 33.89525848991309 562.7589740100873 22.23179175937821 346.4518682406222 41.609348701990484 1553.1288712980102 DOWN 0.375 0.625 0.0 GO:0001101 4 response to acid chemical 195 202 10 10 8 8 7 7 31 195 2314 0.99167 0.027047 0.027047 3.47 24522;25044;24314;24450;24253;25612;25748 zfp354a;sds;nqo1;hmgcs2;cebpb;asns;alas2 ZFP354A_10203;SDS_9798;NQO1_33055;HMGCS2_8812;CEBPB_32843,CEBPB_8282;ASNS_8091;ALAS2_8019 24253(-0.009836) 234.82468571428572 106.351 40.5511 244.24590026702208 180.06826894051258 212.77083634688745 153.76835714285716 71.0566 21.5832 165.88818251349167 115.14683161058962 144.99431897558333 467.37045714285716 208.329 79.3552 485.3981452772519 361.0538971152832 423.5593550987407 99.2226;553.681;40.5511;106.351;620.8109999999999;157.765;65.3911 71.0566;377.484;21.5832;59.8697;409.549;99.5663;37.2697 163.536;1035.66;79.3552;208.329;1279.85;371.219;133.644 3 5 3 25044;24314;25612 SDS_9798;NQO1_33055;ASNS_8091 250.66570000000002 157.765 268.8837641321432 166.21116666666666 99.5663 187.07618381270058 495.4114 371.219 490.0995121289962 553.681;40.5511;157.765 377.484;21.5832;99.5663 1035.66;79.3552;371.219 4 24522;24450;24253;25748 ZFP354A_10203;HMGCS2_8812;CEBPB_32843,CEBPB_8282;ALAS2_8019 222.94392499999998 102.7868 265.8458064708108 144.43625 65.46315 177.2996654109364 446.33975 185.9325 556.5204539675517 99.2226;106.351;620.8109999999999;65.3911 71.0566;59.8697;409.549;37.2697 163.536;208.329;1279.85;133.644 0 Exp 4,2(0.25);Exp 5,1(0.13);Linear,3(0.38);Poly 2,2(0.25) 1.8467960311054281 15.088851809501648 1.5452189445495605 2.5798087120056152 0.4374187820027544 1.692491590976715 53.88479067527072 415.76458075330066 30.87667175780318 276.66004252791106 107.7824789512863 826.9584353344278 CONFLICT 0.42857142857142855 0.5714285714285714 0.0 GO:0060255 5 regulation of macromolecule metabolic process 1000 1070 38 34 24 24 16 16 22 1054 1455 0.57359 0.55757 1.0 1.5 24522;360772;362246;360243;363328;89829;299276;25106;363140;316351;114519;499271;83928;361921;60628;24253 zfp354a;zfand2a;tp53inp2;top2a;ticam1;socs3;serpina3m;rgn;rassf1;npas2;nfil3;itgax;fetub;ect2;cxcr4;cebpb ZFP354A_10203;ZFAND2A_10197;TP53INP2_32755;TOP2A_10059;TICAM1_10015;SOCS3_32863;SERPINA3M_9809;RGN_9699;RASSF1_32475;NPAS2_9350;NFIL3_9304;ITGAX_32980;FETUB_33027;ECT2_8523;CXCR4_8411;CEBPB_32843,CEBPB_8282 24253(-0.009836) 453.2027937500001 506.3805 1.65461E-12 361.70549804678836 495.7297332354005 354.87261475883685 292.68473562500014 339.145 1.65461E-12 236.495991761709 323.0152624871181 235.68574885423553 1004.5448875000001 947.6805 1.65462E-12 894.2007657464825 1037.6466159442236 836.9464854358887 99.2226;946.037;827.265;12.3342;811.122;809.124;466.86;752.835;903.848;155.028;121.321;148.304;545.901;31.2319;1.65461E-12;620.8109999999999 71.0566;687.617;495.492;3.46407;489.389;488.627;296.126;458.716;608.514;98.033;82.5516;95.184;382.164;16.4725;1.65461E-12;409.549 163.536;1292.08;2498.6;46.5267;2362.87;2346.74;918.743;1994.77;1171.72;382.695;229.79;340.985;976.618;67.1945;1.65462E-12;1279.85 4 13 4 360772;89829;363140;83928 ZFAND2A_10197;SOCS3_32863;RASSF1_32475;FETUB_33027 801.2275 856.486 179.58724400227734 541.7304999999999 548.5705 134.19433220644422 1446.7894999999999 1231.9 613.8866347795823 946.037;809.124;903.848;545.901 687.617;488.627;608.514;382.164 1292.08;2346.74;1171.72;976.618 12 24522;362246;360243;363328;299276;25106;316351;114519;499271;361921;60628;24253 ZFP354A_10203;TP53INP2_32755;TOP2A_10059;TICAM1_10015;SERPINA3M_9809;RGN_9699;NPAS2_9350;NFIL3_9304;ITGAX_32980;ECT2_8523;CXCR4_8411;CEBPB_32843,CEBPB_8282 337.1945583333334 151.666 332.993115172981 209.6694808333335 96.60849999999999 203.18764145741554 857.1300166666668 361.84000000000003 944.8549586618204 99.2226;827.265;12.3342;811.122;466.86;752.835;155.028;121.321;148.304;31.2319;1.65461E-12;620.8109999999999 71.0566;495.492;3.46407;489.389;296.126;458.716;98.033;82.5516;95.184;16.4725;1.65461E-12;409.549 163.536;2498.6;46.5267;2362.87;918.743;1994.77;382.695;229.79;340.985;67.1945;1.65462E-12;1279.85 0 Exp 2,3(0.18);Exp 4,1(0.06);Hill,2(0.12);Linear,5(0.3);Poly 2,6(0.36) 1.8601953215337041 32.28894400596619 1.5054508447647095 2.846071243286133 0.4235124716379954 1.7404011487960815 275.96709970707377 630.4384877929264 176.8016996617627 408.5677715882376 566.3865122842235 1442.7032627157764 DOWN 0.25 0.75 0.0 GO:0030855 5 epithelial cell differentiation 87 96 3 3 3 3 3 3 35 93 2416 0.94747 0.17049 0.17049 3.12 24296;60628;24253 cyp1a1;cxcr4;cebpb CYP1A1_8415;CXCR4_8411;CEBPB_32843,CEBPB_8282 24253(-0.009836) 223.28530000000055 49.0449 1.65461E-12 345.1396270705084 170.7536088417498 298.55346309631284 149.59510000000054 39.2363 1.65461E-12 225.97985397669797 116.92241626306264 194.36620794124397 448.23430000000053 64.8529 1.65462E-12 720.9299404411424 329.49080157061536 629.4863641893494 49.0449;1.65461E-12;620.8109999999999 39.2363;1.65461E-12;409.549 64.8529;1.65462E-12;1279.85 1 3 1 24296 CYP1A1_8415 49.0449 49.0449 39.2363 39.2363 64.8529 64.8529 49.0449 39.2363 64.8529 2 60628;24253 CXCR4_8411;CEBPB_32843,CEBPB_8282 310.4055000000008 310.4055000000008 438.9796679352005 204.7745000000008 204.7745000000008 289.59487512816816 639.9250000000008 639.9250000000008 904.9906139016016 1.65461E-12;620.8109999999999 1.65461E-12;409.549 1.65462E-12;1279.85 0 Hill,1(0.25);Linear,2(0.5);Poly 2,1(0.25) 2.5198352111263014 13.805684685707092 1.5669527053833008 8.822484970092773 3.58145058261033 1.708123505115509 -167.27695493044297 613.847554930444 -106.12517786876211 405.3153778687632 -367.5747265538863 1264.0433265538873 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0017144 4 drug metabolic process 142 165 7 7 7 6 6 6 32 159 2350 0.99038 0.03299 0.03299 3.64 24450;266674;266684;29277;24296;25612 hmgcs2;cyp4a8;cyp2d1;cyp2c11;cyp1a1;asns HMGCS2_8812;CYP4A8_32747;CYP2D1_32660;CYP2C11_32593;CYP1A1_8415;ASNS_8091 122.21825000000001 116.549 49.0449 59.83443800286753 108.78884718594016 55.82455182491295 80.20068333333333 72.51145 39.2363 36.09975266194582 70.5983291926951 33.41913239262444 229.46765000000002 229.454 64.8529 127.38120643350408 206.0871665391398 124.83015371258027 106.351;76.6586;126.747;216.743;49.0449;157.765 59.8697;57.8156;85.1532;139.563;39.2363;99.5663 208.329;112.882;250.579;368.944;64.8529;371.219 4 2 4 266674;266684;24296;25612 CYP4A8_32747;CYP2D1_32660;CYP1A1_8415;ASNS_8091 102.553875 101.7028 48.87859549914627 70.44285 71.4844 27.066990612737108 199.88322499999998 181.7305 138.71843330863607 76.6586;126.747;49.0449;157.765 57.8156;85.1532;39.2363;99.5663 112.882;250.579;64.8529;371.219 2 24450;29277 HMGCS2_8812;CYP2C11_32593 161.547 161.547 78.05893178874537 99.71634999999999 99.71634999999999 56.35167284513388 288.6365 288.6365 113.5719556602773 106.351;216.743 59.8697;139.563 208.329;368.944 0 Exp 2,1(0.17);Exp 4,1(0.17);Poly 2,4(0.67) 3.0138111449624536 24.494088530540466 1.5671749114990234 8.822484970092773 3.5144604503365553 2.0891588926315308 74.34072822994811 170.0957717700519 51.31486520493428 109.08650146173238 127.54145686314311 331.39384313685696 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0071495 4 cellular response to endogenous stimulus 313 332 11 8 6 7 4 4 34 328 2181 0.43568 0.74982 0.81039 1.2 24587;24450;24253;25612 nefh;hmgcs2;cebpb;asns NEFH_33218;HMGCS2_8812;CEBPB_32843,CEBPB_8282;ASNS_8091 24253(-0.009836) 221.23175000000072 132.058 2.95157E-12 274.36756326428764 196.25511441454873 234.984080292516 142.2462500000007 79.718 2.95157E-12 182.84075942244493 123.76062002378515 157.684515836973 464.8495000000007 289.774 2.95158E-12 564.1750053842622 410.48873767405024 485.29999670841653 2.95157E-12;106.351;620.8109999999999;157.765 2.95157E-12;59.8697;409.549;99.5663 2.95158E-12;208.329;1279.85;371.219 1 4 1 25612 ASNS_8091 157.765 157.765 99.5663 99.5663 371.219 371.219 157.765 99.5663 371.219 3 24587;24450;24253 NEFH_33218;HMGCS2_8812;CEBPB_32843,CEBPB_8282 242.38733333333428 106.351 332.0105230566233 156.47290000000098 59.8697 221.20517520602795 496.0596666666676 208.329 686.7282636023741 2.95157E-12;106.351;620.8109999999999 2.95157E-12;59.8697;409.549 2.95158E-12;208.329;1279.85 0 Exp 4,1(0.2);Hill,1(0.2);Linear,2(0.4);Poly 2,1(0.2) 1.924656582250591 9.861042499542236 1.5669527053833008 2.578549861907959 0.495845524250325 1.671766996383667 -47.64846199900114 490.1119619990026 -36.9376942339953 321.43019423399676 -88.04200527657628 1017.7410052765779 DOWN 0.25 0.75 0.0 GO:0048609 3 multicellular organismal reproductive process 128 145 5 5 4 3 3 3 35 142 2367 0.83272 0.36889 0.47491 2.07 25106;24296;25748 rgn;cyp1a1;alas2 RGN_9699;CYP1A1_8415;ALAS2_8019 289.0903333333334 65.3911 49.0449 401.6978173452569 153.29823514854016 296.34122275523345 178.40733333333333 39.2363 37.2697 242.7564177014139 97.24969834841744 178.58544622070403 731.0889666666667 133.644 64.8529 1094.9202570802145 359.17641539602187 808.9763585776783 752.835;49.0449;65.3911 458.716;39.2363;37.2697 1994.77;64.8529;133.644 1 2 1 24296 CYP1A1_8415 49.0449 49.0449 39.2363 39.2363 64.8529 64.8529 49.0449 39.2363 64.8529 2 25106;25748 RGN_9699;ALAS2_8019 409.11305000000004 409.11305000000004 486.0962433753269 247.99285 247.99285 298.0075366359801 1064.2069999999999 1064.2069999999999 1316.0148152425945 752.835;65.3911 458.716;37.2697 1994.77;133.644 0 Exp 2,1(0.34);Exp 5,1(0.34);Poly 2,1(0.34) 2.959441093885271 12.250550627708435 1.7132161855697632 8.822484970092773 4.104066838541863 1.7148494720458984 -165.47353890191835 743.654205568585 -96.29741355721092 453.11208022387757 -507.9299434595482 1970.1078767928816 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0071103 7 DNA conformation change 30 32 3 3 3 2 2 2 36 30 2479 0.98872 0.081247 0.081247 6.25 360243;291885 top2a;mcm5 TOP2A_10059;MCM5_9209 12.4174 12.4174 12.3342 0.11766256838939407 12.360684489519945 0.08608822069248198 6.56955 6.56955 3.46407 4.391811933678399 4.452616304259634 3.2132842259093857 41.30615 41.30615 36.0856 7.382972613046798 44.86487786342123 5.401777169896827 0.5 12.4174 12.3342;12.5006 3.46407;9.67503 46.5267;36.0856 0 2 0 2 360243;291885 TOP2A_10059;MCM5_9209 12.4174 12.4174 0.11766256838939407 6.56955 6.56955 4.391811933678399 41.30615 41.30615 7.382972613046798 12.3342;12.5006 3.46407;9.67503 46.5267;36.0856 0 Exp 5,1(0.5);Hill,1(0.5) 2.2485975043877238 4.62262225151062 1.7765510082244873 2.846071243286133 0.7562650108283199 2.31131112575531 12.254328 12.580472000000002 0.48280920000000016 12.656290799999999 31.073872000000005 51.538427999999996 DOWN 0.0 1.0 0.0 GO:0006928 3 movement of cell or subcellular component 248 268 9 8 7 3 3 3 35 265 2244 0.42149 0.77994 0.79196 1.12 315740;361308;60628 kif23;kif20a;cxcr4 KIF23_32798;KIF20A_8961;CXCR4_8411 15.204266666667218 10.3381 1.65461E-12 18.133830222633836 11.641537946518065 13.391393677090642 6.594093333333885 4.23628 1.65461E-12 8.036727678982437 4.9375505328281815 5.932963783034998 39.41686666666722 21.7065 1.65462E-12 50.650109839992126 27.88626077629256 37.43579044531521 10.3381;35.2747;1.65461E-12 4.23628;15.546;1.65461E-12 21.7065;96.5441;1.65462E-12 0 3 0 3 315740;361308;60628 KIF23_32798;KIF20A_8961;CXCR4_8411 15.204266666667218 10.3381 18.133830222633836 6.594093333333885 4.23628 8.036727678982437 39.41686666666722 21.7065 50.650109839992126 10.3381;35.2747;1.65461E-12 4.23628;15.546;1.65461E-12 21.7065;96.5441;1.65462E-12 0 Exp 4,1(0.34);Exp 5,1(0.34);Hill,1(0.34) 1.7041579596733076 5.11807119846344 1.595955729484558 1.7776354551315308 0.09675249268398525 1.744480013847351 -5.316093983866946 35.72462731720138 -2.50032016884 15.688506835507768 -17.899128252515787 96.73286158585023 DOWN 0.0 1.0 0.0 GO:0071407 6 cellular response to organic cyclic compound 197 209 9 8 6 6 4 4 34 205 2304 0.80316 0.38031 0.54806 1.91 24587;24450;24296;24253 nefh;hmgcs2;cyp1a1;cebpb NEFH_33218;HMGCS2_8812;CYP1A1_8415;CEBPB_32843,CEBPB_8282 24253(-0.009836) 194.05172500000072 77.69794999999999 2.95157E-12 287.80661750331956 145.81979833990567 226.92371101124058 127.16375000000073 49.553 2.95157E-12 189.8874880558917 95.19438921135678 149.2737277088187 388.2579750000007 136.59095000000002 2.95158E-12 600.7345150660718 282.49584688091517 477.040181308837 2.95157E-12;106.351;49.0449;620.8109999999999 2.95157E-12;59.8697;39.2363;409.549 2.95158E-12;208.329;64.8529;1279.85 1 4 1 24296 CYP1A1_8415 49.0449 49.0449 39.2363 39.2363 64.8529 64.8529 49.0449 39.2363 64.8529 3 24587;24450;24253 NEFH_33218;HMGCS2_8812;CEBPB_32843,CEBPB_8282 242.38733333333428 106.351 332.0105230566233 156.47290000000098 59.8697 221.20517520602795 496.0596666666676 208.329 686.7282636023741 2.95157E-12;106.351;620.8109999999999 2.95157E-12;59.8697;409.549 2.95158E-12;208.329;1279.85 0 Exp 4,1(0.2);Hill,1(0.2);Linear,2(0.4);Poly 2,1(0.2) 2.7080709461287538 17.083759546279907 1.5669527053833008 8.822484970092773 3.0552208824865255 2.444005012512207 -87.99876015325242 476.10221015325385 -58.925988294773134 313.25348829477457 -200.46184976474956 976.9777997647509 DOWN 0.25 0.75 0.0 GO:0032496 5 response to lipopolysaccharide 176 189 9 9 8 6 5 5 33 184 2325 0.94201 0.14659 0.19881 2.65 363328;89829;24450;24296;24253 ticam1;socs3;hmgcs2;cyp1a1;cebpb TICAM1_10015;SOCS3_32863;HMGCS2_8812;CYP1A1_8415;CEBPB_32843,CEBPB_8282 24253(-0.009836) 479.29058 620.8109999999999 49.0449 375.2084357441634 373.38337945532015 385.69309659729447 297.33419999999995 409.549 39.2363 228.62308370907132 230.81734049640954 234.21039703095244 1252.52838 1279.85 64.8529 1110.3861315272593 978.1851314591343 1135.803920241604 811.122;809.124;106.351;49.0449;620.8109999999999 489.389;488.627;59.8697;39.2363;409.549 2362.87;2346.74;208.329;64.8529;1279.85 2 4 2 89829;24296 SOCS3_32863;CYP1A1_8415 429.08445 429.08445 537.457085848168 263.93165 263.93165 317.76721137216947 1205.7964499999998 1205.7964499999998 1613.5378423121053 809.124;49.0449 488.627;39.2363 2346.74;64.8529 3 363328;24450;24253 TICAM1_10015;HMGCS2_8812;CEBPB_32843,CEBPB_8282 512.7613333333333 620.8109999999999 364.59784483775167 319.6025666666667 409.549 228.45016506924065 1283.683 1279.85 1077.275614263592 811.122;106.351;620.8109999999999 489.389;59.8697;409.549 2362.87;208.329;1279.85 0 Exp 4,1(0.17);Linear,4(0.67);Poly 2,1(0.17) 2.3297078809296026 17.921718955039978 1.5415632724761963 8.822484970092773 2.8847663524164027 1.7060840725898743 150.405885322318 808.175274677682 96.93723149154968 497.7311685084503 279.2320224237544 2225.8247375762458 DOWN 0.4 0.6 0.0 GO:1901564 4 organonitrogen compound metabolic process 832 911 27 25 15 15 8 8 30 903 1606 0.037521 0.9844 0.061269 0.88 362246;89829;25044;24450;24296;25612;25748;54223 tp53inp2;socs3;sds;hmgcs2;cyp1a1;asns;alas2;adcy4 TP53INP2_32755;SOCS3_32863;SDS_9798;HMGCS2_8812;CYP1A1_8415;ASNS_8091;ALAS2_8019;ADCY4_7988 410.63174999999995 355.723 49.0449 349.0437434155374 356.7685124719968 355.7878286518906 248.906625 238.52515 37.2697 207.9007695345598 214.8212816975666 210.7494215933304 1093.2656125 703.4395000000001 64.8529 1056.9578103065692 962.3932435477017 1078.045802568158 827.265;809.124;553.681;106.351;49.0449;157.765;65.3911;716.432 495.492;488.627;377.484;59.8697;39.2363;99.5663;37.2697;393.708 2498.6;2346.74;1035.66;208.329;64.8529;371.219;133.644;2087.08 4 4 4 89829;25044;24296;25612 SOCS3_32863;SDS_9798;CYP1A1_8415;ASNS_8091 392.403725 355.723 352.42813026322955 251.22839999999997 238.52515 216.2102486409468 954.617975 703.4395000000001 1012.6874797664227 809.124;553.681;49.0449;157.765 488.627;377.484;39.2363;99.5663 2346.74;1035.66;64.8529;371.219 4 362246;24450;25748;54223 TP53INP2_32755;HMGCS2_8812;ALAS2_8019;ADCY4_7988 428.859775 411.3915 398.9761461361683 246.58485000000002 226.78885000000002 232.5764174388639 1231.91325 1147.7045 1236.89470789753 827.265;106.351;65.3911;716.432 495.492;59.8697;37.2697;393.708 2498.6;208.329;133.644;2087.08 0 Exp 2,1(0.13);Exp 4,1(0.13);Exp 5,1(0.13);Linear,3(0.38);Poly 2,2(0.25) 2.137485571272906 21.224637627601624 1.5452189445495605 8.822484970092773 2.5153486856593847 1.682142198085785 168.7567760581335 652.5067239418665 104.83874192724699 392.974508072753 360.83121810605746 1825.7000068939428 CONFLICT 0.5 0.5 0.0 GO:0006171 9 cAMP biosynthetic process 3 3 1 1 1 1 1 1 37 2 2507 0.99936 0.044111 0.044111 33.33 54223 adcy4 ADCY4_7988 716.432 716.432 716.432 716.432 393.708 393.708 393.708 393.708 2087.08 2087.08 2087.08 2087.08 0.0 716.432 0.0 716.432 716.432 393.708 2087.08 0 1 0 1 54223 ADCY4_7988 716.432 716.432 393.708 393.708 2087.08 2087.08 716.432 393.708 2087.08 0 Exp 2,1(1) 1.6510682106018066 1.6510682106018066 1.6510682106018066 1.6510682106018066 0.0 1.6510682106018066 716.432 716.432 393.708 393.708 2087.08 2087.08 DOWN 0.0 1.0 0.0 GO:0042738 6 exogenous drug catabolic process 17 20 2 2 2 2 2 2 36 18 2491 0.99707 0.034783 0.034783 10.0 266684;29277 cyp2d1;cyp2c11 CYP2D1_32660;CYP2C11_32593 171.745 171.745 126.747 63.63678187966449 161.58985224209752 61.995047834728986 112.3581 112.3581 85.1532 38.47353854300377 106.21849870129869 37.48097863991779 309.7615 309.7615 250.579 83.69669415514556 296.4051945601569 81.53744429705417 0.0 126.747 1.0 216.743 126.747;216.743 85.1532;139.563 250.579;368.944 1 1 1 266684 CYP2D1_32660 126.747 126.747 85.1532 85.1532 250.579 250.579 126.747 85.1532 250.579 1 29277 CYP2C11_32593 216.743 216.743 139.563 139.563 368.944 368.944 216.743 139.563 368.944 0 Exp 2,1(0.5);Poly 2,1(0.5) 3.6181400418949687 9.920382499694824 1.5671749114990234 8.3532075881958 4.798449723045789 4.960191249847412 83.54892000000002 259.94108 59.03649600000001 165.679704 193.7638 425.7592 CONFLICT 0.5 0.5 0.0 GO:0051493 7 regulation of cytoskeleton organization 126 131 7 6 3 5 2 2 36 129 2380 0.6896 0.59043 1.0 1.53 363140;361921 rassf1;ect2 RASSF1_32475;ECT2_8523 467.53995 467.53995 31.2319 617.0327616825584 798.9493210729344 401.3291498504549 312.49325 312.49325 16.4725 418.63655939385546 537.3436752489459 272.2887096297998 619.45725 619.45725 67.1945 781.017471043462 1038.9430941060375 507.9877392855218 903.848;31.2319 608.514;16.4725 1171.72;67.1945 1 1 1 363140 RASSF1_32475 903.848 903.848 608.514 608.514 1171.72 1171.72 903.848 608.514 1171.72 1 361921 ECT2_8523 31.2319 31.2319 16.4725 16.4725 67.1945 67.1945 31.2319 16.4725 67.1945 0 Exp 4,1(0.5);Poly 2,1(0.5) 2.3909602591543253 4.808029890060425 2.1538212299346924 2.6542086601257324 0.3538273451085946 2.4040149450302124 -387.6238279999999 1322.703728 -267.70742000000007 892.69392 -462.9777399999997 1701.8922399999997 CONFLICT 0.5 0.5 0.0 GO:0051726 5 regulation of cell cycle 252 268 26 24 16 14 8 8 30 260 2249 0.98555 0.040101 0.054257 2.99 360243;363140;304477;315740;361308;361921;24296;25612 top2a;rassf1;kntc1;kif23;kif20a;ect2;cyp1a1;asns TOP2A_10059;RASSF1_32475;KNTC1_8976;KIF23_32798;KIF20A_8961;ECT2_8523;CYP1A1_8415;ASNS_8091 151.5742625 33.2533 10.3381 307.775391587506 229.94204817179593 381.5730459691869 99.583665 16.00925 3.46407 208.06686820874006 154.1622600234187 257.1799915095958 235.005875 66.0237 21.7065 394.82539124680983 326.64295737357224 486.5915064755197 12.3342;903.848;12.7573;10.3381;35.2747;31.2319;49.0449;157.765 3.46407;608.514;9.63387;4.23628;15.546;16.4725;39.2363;99.5663 46.5267;1171.72;40.2833;21.7065;96.5441;67.1945;64.8529;371.219 3 5 3 363140;24296;25612 RASSF1_32475;CYP1A1_8415;ASNS_8091 370.2193 157.765 465.322154140301 249.10553333333334 99.5663 312.7151445945069 535.9306333333334 371.219 571.5208971525917 903.848;49.0449;157.765 608.514;39.2363;99.5663 1171.72;64.8529;371.219 5 360243;304477;315740;361308;361921 TOP2A_10059;KNTC1_8976;KIF23_32798;KIF20A_8961;ECT2_8523 20.387240000000002 12.7573 11.866926393889866 9.870544 9.63387 6.095910070500546 54.45102000000001 46.5267 28.591722551675677 12.3342;12.7573;10.3381;35.2747;31.2319 3.46407;9.63387;4.23628;15.546;16.4725 46.5267;40.2833;21.7065;96.5441;67.1945 0 Exp 4,2(0.25);Exp 5,2(0.25);Hill,1(0.13);Poly 2,3(0.38) 2.4217166671131958 23.265815019607544 1.595955729484558 8.822484970092773 2.435498381859601 1.984845519065857 -61.70320264439317 364.8517276443932 -44.599318581634805 243.7666485816348 -38.594162304545904 508.605912304546 DOWN 0.375 0.625 0.0