Gene Ontology Analyses GO Category: BP GO File Creation Date: 07/15/20 Deduplicate Gene Sets: true Data Source: Liver_2,3-Benzofluorene_Female Work Source: Liver_2,3-Benzofluorene_Female_williams_0.05_NOMTC_foldfilter1.5_BMD BMDExpress2 Version: BMDExpress 2.30.0507 BETA Timestamp (Start Time): 02/12/2021 22:59.30 Remove Promiscuous Probes: true Remove BMD > Highest Dose from Category Descriptive Statistics: true Remove BMD with p-Value < Cutoff: 0.1 Remove genes with BMDU/BMDL >: 40.0 Identify conflicting probe sets: 0.5 Category Count: 3175 Total Run Time: 0 seconds GO/Pathway/Gene Set/Gene ID GO Level GO/Pathway/Gene Set/Gene Name All Genes (Expression Data) All Genes (Platform) Input Genes Genes with BMD <= Highest Dose Genes with BMD p-Value >= Genes with BMDU/BMDL <= Genes That Passed All Filters Fisher's A Parameter Fisher's B Parameter Fisher's C Parameter Fisher's D Parameter Fisher's Exact Left P-Value Fisher's Exact Right P-Value Fisher's Exact Two Tail Percentage Entrez Gene IDs Gene Symbols Probe IDs Genes with Conflicting Probesets BMD Mean BMD Median BMD Minimum BMD Standard Deviation BMD wMean BMD wSD BMDL Mean BMDL Median BMDL Minimum BMDL Standard Deviation BMDL wMean BMDL wSD BMDU Mean BMDU Median BMDU Minimum BMDU Standard Deviation BMDU wMean BMDU wSD 5th Percentile Index BMD at 5th Percentile of Total Genes 10th Percentile Index BMD at 10th Percentile of Total Genes BMD List BMDL List BMDU List Probes with Adverse Direction Up Probes with Adverse Direction Down Genes with Adverse Direction Up Genes Up List Genes Up Probes List Genes Up BMD Mean Genes Up BMD Median Genes Up SD Genes Up BMDL Mean Genes Up BMDL Median Genes Up BMDL SD Genes Up BMDU Mean Genes Up BMDU Median Genes Up BMDU SD BMD list (up) BMDL List (up) BMDU List (up) Genes with Adverse Direction Down Genes Down List Genes Down Probes List Genes Down BMD Mean Genes Down BMD Median Genes Down SD Genes Down BMDL Mean Genes Down BMDL Median Genes Down BMDL SD Genes Down BMDU Mean Genes Down BMDU Median Genes Down BMDU SD BMD list (down) BMDL List (down) BMDU List (down) Genes with Adverse Conflict Count Genes Conflict List Genes Conflict Probes List BMD list (Conflict) BMDL list (Conflict) BMDU list (Conflict) Model Counts Mean Fold Change Total Fold Change Min Fold Change Max Fold Change Standard Deviation Fold Change Median Fold Change Lower bound of the 95% confidence interval - BMD Upper bound of the 95% confidence interval - BMD Lower bound of the 95% confidence interval - BMDL Upper bound of the 95% confidence interval - BMDL Lower bound of the 95% confidence interval - BMDU Upper bound of the 95% confidence interval - BMDU Overall Direction Percent Genes With Overall Direction Up Percent Genes With Overall Direction Down Percent Genes With Overall Direction Conflict GO:0000070 6 mitotic sister chromatid segregation 13 13 2 2 2 0 0 0 69 13 2465 0.69915 1.0 1.0 0.0 0 0 0 0 0 GO:0000077 8 DNA damage checkpoint 17 18 1 1 1 0 0 0 69 18 2460 0.60894 1.0 1.0 0.0 0 0 0 0 0 GO:0000079 8 regulation of cyclin-dependent protein serine/threonine kinase activity 33 33 2 2 2 0 0 0 69 33 2445 0.40166 1.0 1.0 0.0 0 0 0 0 0 GO:0000086 6 G2/M transition of mitotic cell cycle 16 16 2 2 2 0 0 0 69 16 2462 0.64355 1.0 1.0 0.0 0 0 0 0 0 GO:0000132 8 establishment of mitotic spindle orientation 8 8 1 1 1 0 0 0 69 8 2470 0.8025 1.0 1.0 0.0 0 0 0 0 0 GO:0000165 8 MAPK cascade 43 45 2 2 1 1 0 0 69 45 2433 0.28741 1.0 0.63336 0.0 0 0 0 0 0 GO:0000212 7 meiotic spindle organization 7 7 1 1 1 0 0 0 69 7 2471 0.82491 1.0 1.0 0.0 0 0 0 0 0 GO:0000226 5 microtubule cytoskeleton organization 73 80 8 8 8 0 0 0 69 80 2398 0.10727 1.0 0.27655 0.0 0 0 0 0 0 GO:0000281 5 mitotic cytokinesis 13 16 4 4 4 0 0 0 69 16 2462 0.64355 1.0 1.0 0.0 0 0 0 0 0 GO:0000375 9 RNA splicing, via transesterification reactions 13 15 1 1 1 0 0 0 69 15 2463 0.66158 1.0 1.0 0.0 0 0 0 0 0 GO:0000377 10 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 13 15 1 1 1 0 0 0 69 15 2463 0.66158 1.0 1.0 0.0 0 0 0 0 0 GO:0000398 9 mRNA splicing, via spliceosome 13 15 1 1 1 0 0 0 69 15 2463 0.66158 1.0 1.0 0.0 0 0 0 0 0 GO:0000738 7 DNA catabolic process, exonucleolytic 2 2 1 1 1 0 0 0 69 2 2476 0.94654 1.0 1.0 0.0 0 0 0 0 0 GO:0000820 7 regulation of glutamine family amino acid metabolic process 2 2 1 1 0 1 0 0 69 2 2476 0.94654 1.0 1.0 0.0 0 0 0 0 0 GO:0000902 4 cell morphogenesis 62 65 1 1 1 0 0 0 69 65 2413 0.16393 1.0 0.42101 0.0 0 0 0 0 0 GO:0000910 4 cytokinesis 16 19 4 4 4 0 0 0 69 19 2459 0.59232 1.0 1.0 0.0 0 0 0 0 0 GO:0001578 6 microtubule bundle formation 6 7 1 1 1 0 0 0 69 7 2471 0.82491 1.0 1.0 0.0 0 0 0 0 0 GO:0001649 5 osteoblast differentiation 27 27 1 1 1 0 0 0 69 27 2451 0.47454 1.0 1.0 0.0 0 0 0 0 0 GO:0001655 5 urogenital system development 6 8 1 1 0 1 0 0 69 8 2470 0.8025 1.0 1.0 0.0 0 0 0 0 0 GO:0001656 6 metanephros development 10 10 1 1 1 0 0 0 69 10 2468 0.75947 1.0 1.0 0.0 0 0 0 0 0 GO:0001764 5 neuron migration 31 35 2 2 2 0 0 0 69 35 2443 0.37991 1.0 1.0 0.0 0 0 0 0 0 GO:0001816 5 cytokine production 29 29 2 2 2 0 0 0 69 29 2449 0.44891 1.0 1.0 0.0 0 0 0 0 0 GO:0001822 5 kidney development 48 53 2 2 1 1 0 0 69 53 2425 0.22972 1.0 0.40146 0.0 0 0 0 0 0 GO:0001910 6 regulation of leukocyte mediated cytotoxicity 21 29 1 1 1 0 0 0 69 29 2449 0.44891 1.0 1.0 0.0 0 0 0 0 0 GO:0001912 7 positive regulation of leukocyte mediated cytotoxicity 16 23 1 1 1 0 0 0 69 23 2455 0.53022 1.0 1.0 0.0 0 0 0 0 0 GO:0001914 7 regulation of T cell mediated cytotoxicity 12 19 1 1 1 0 0 0 69 19 2459 0.59232 1.0 1.0 0.0 0 0 0 0 0 GO:0001916 8 positive regulation of T cell mediated cytotoxicity 9 16 1 1 1 0 0 0 69 16 2462 0.64355 1.0 1.0 0.0 0 0 0 0 0 GO:0001935 5 endothelial cell proliferation 7 8 1 1 1 0 0 0 69 8 2470 0.8025 1.0 1.0 0.0 0 0 0 0 0 GO:0001936 7 regulation of endothelial cell proliferation 43 44 1 1 0 1 0 0 69 44 2434 0.29556 1.0 0.6315 0.0 0 0 0 0 0 GO:0001938 8 positive regulation of endothelial cell proliferation 29 29 1 1 0 1 0 0 69 29 2449 0.44891 1.0 1.0 0.0 0 0 0 0 0 GO:0001952 7 regulation of cell-matrix adhesion 37 39 1 1 1 0 0 0 69 39 2439 0.33983 1.0 0.62521 0.0 0 0 0 0 0 GO:0001960 7 negative regulation of cytokine-mediated signaling pathway 13 13 2 2 1 1 0 0 69 13 2465 0.69915 1.0 1.0 0.0 0 0 0 0 0 GO:0001975 5 response to amphetamine 19 21 1 1 1 0 0 0 69 21 2457 0.56042 1.0 1.0 0.0 0 0 0 0 0 GO:0001977 6 renal system process involved in regulation of blood volume 4 5 1 1 1 0 0 0 69 5 2473 0.87159 1.0 1.0 0.0 0 0 0 0 0 GO:0001990 6 regulation of systemic arterial blood pressure by hormone 7 10 2 2 1 1 0 0 69 10 2468 0.75947 1.0 1.0 0.0 0 0 0 0 0 GO:0001998 8 angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure 2 2 1 1 1 0 0 0 69 2 2476 0.94654 1.0 1.0 0.0 0 0 0 0 0 GO:0002016 8 regulation of blood volume by renin-angiotensin 2 3 1 1 0 1 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:0002017 6 regulation of blood volume by renal aldosterone 1 2 1 1 1 0 0 0 69 2 2476 0.94654 1.0 1.0 0.0 0 0 0 0 0 GO:0002019 9 regulation of renal output by angiotensin 2 2 1 1 0 1 0 0 69 2 2476 0.94654 1.0 1.0 0.0 0 0 0 0 0 GO:0002023 5 reduction of food intake in response to dietary excess 1 1 1 1 1 0 0 0 69 1 2477 0.97291 1.0 1.0 0.0 0 0 0 0 0 GO:0002033 8 angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure 1 1 1 1 1 0 0 0 69 1 2477 0.97291 1.0 1.0 0.0 0 0 0 0 0 GO:0002052 8 positive regulation of neuroblast proliferation 7 8 1 1 1 0 0 0 69 8 2470 0.8025 1.0 1.0 0.0 0 0 0 0 0 GO:0002069 6 columnar/cuboidal epithelial cell maturation 3 4 1 1 1 0 0 0 69 4 2474 0.8959 1.0 1.0 0.0 0 0 0 0 0 GO:0002070 5 epithelial cell maturation 7 8 1 1 1 0 0 0 69 8 2470 0.8025 1.0 1.0 0.0 0 0 0 0 0 GO:0002221 5 pattern recognition receptor signaling pathway 26 28 1 1 0 1 0 0 69 28 2450 0.46155 1.0 1.0 0.0 0 0 0 0 0 GO:0002224 6 toll-like receptor signaling pathway 21 23 1 1 0 1 0 0 69 23 2455 0.53022 1.0 1.0 0.0 0 0 0 0 0 GO:0002250 4 adaptive immune response 53 57 1 1 0 1 0 0 69 57 2421 0.20532 1.0 0.40459 0.0 0 0 0 0 0 GO:0002696 6 positive regulation of leukocyte activation 96 103 3 3 2 1 0 0 69 103 2375 0.055694 1.0 0.11344 0.0 0 0 0 0 0 GO:0002701 7 negative regulation of production of molecular mediator of immune response 11 12 1 1 1 0 0 0 69 12 2466 0.71871 1.0 1.0 0.0 0 0 0 0 0 GO:0002719 7 negative regulation of cytokine production involved in immune response 11 12 1 1 1 0 0 0 69 12 2466 0.71871 1.0 1.0 0.0 0 0 0 0 0 GO:0002739 7 regulation of cytokine secretion involved in immune response 6 7 1 1 1 0 0 0 69 7 2471 0.82491 1.0 1.0 0.0 0 0 0 0 0 GO:0002740 7 negative regulation of cytokine secretion involved in immune response 3 4 1 1 1 0 0 0 69 4 2474 0.8959 1.0 1.0 0.0 0 0 0 0 0 GO:0002761 7 regulation of myeloid leukocyte differentiation 45 48 1 1 0 1 0 0 69 48 2430 0.26427 1.0 0.63996 0.0 0 0 0 0 0 GO:0002762 8 negative regulation of myeloid leukocyte differentiation 20 20 1 1 0 1 0 0 69 20 2458 0.57616 1.0 1.0 0.0 0 0 0 0 0 GO:0002763 8 positive regulation of myeloid leukocyte differentiation 25 28 1 1 0 1 0 0 69 28 2450 0.46155 1.0 1.0 0.0 0 0 0 0 0 GO:0002790 6 peptide secretion 29 31 1 1 0 1 0 0 69 31 2447 0.42464 1.0 1.0 0.0 0 0 0 0 0 GO:0002792 7 negative regulation of peptide secretion 35 37 3 3 2 1 0 0 69 37 2441 0.35932 1.0 0.62434 0.0 0 0 0 0 0 GO:0002833 6 positive regulation of response to biotic stimulus 35 36 1 1 0 1 0 0 69 36 2442 0.36948 1.0 0.62432 0.0 0 0 0 0 0 GO:0003002 4 regionalization 36 40 1 1 0 1 0 0 69 40 2438 0.33048 1.0 0.62602 0.0 0 0 0 0 0 GO:0003012 4 muscle system process 68 71 1 1 0 1 0 0 69 71 2407 0.13839 1.0 0.26241 0.0 0 0 0 0 0 GO:0003014 4 renal system process 24 25 2 2 2 0 0 0 69 25 2453 0.50162 1.0 1.0 0.0 0 0 0 0 0 GO:0003044 6 regulation of systemic arterial blood pressure mediated by a chemical signal 9 12 2 2 1 1 0 0 69 12 2466 0.71871 1.0 1.0 0.0 0 0 0 0 0 GO:0003071 5 renal system process involved in regulation of systemic arterial blood pressure 6 7 1 1 1 0 0 0 69 7 2471 0.82491 1.0 1.0 0.0 0 0 0 0 0 GO:0003073 5 regulation of systemic arterial blood pressure 15 18 2 2 1 1 0 0 69 18 2460 0.60894 1.0 1.0 0.0 0 0 0 0 0 GO:0003081 7 regulation of systemic arterial blood pressure by renin-angiotensin 3 5 1 1 0 1 0 0 69 5 2473 0.87159 1.0 1.0 0.0 0 0 0 0 0 GO:0003083 8 negative regulation of renal output by angiotensin 1 1 1 1 0 1 0 0 69 1 2477 0.97291 1.0 1.0 0.0 0 0 0 0 0 GO:0003084 6 positive regulation of systemic arterial blood pressure 6 8 3 3 2 1 0 0 69 8 2470 0.8025 1.0 1.0 0.0 0 0 0 0 0 GO:0003085 6 negative regulation of systemic arterial blood pressure 7 8 1 1 1 0 0 0 69 8 2470 0.8025 1.0 1.0 0.0 0 0 0 0 0 GO:0003106 9 negative regulation of glomerular filtration by angiotensin 1 1 1 1 0 1 0 0 69 1 2477 0.97291 1.0 1.0 0.0 0 0 0 0 0 GO:0003376 6 sphingosine-1-phosphate receptor signaling pathway 2 2 1 1 1 0 0 0 69 2 2476 0.94654 1.0 1.0 0.0 0 0 0 0 0 GO:0006091 4 generation of precursor metabolites and energy 77 85 5 5 3 2 0 0 69 85 2393 0.09307 1.0 0.171 0.0 0 0 0 0 0 GO:0006098 5 pentose-phosphate shunt 3 3 1 1 1 0 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:0006109 6 regulation of carbohydrate metabolic process 61 66 4 4 2 2 0 0 69 66 2412 0.15937 1.0 0.26089 0.0 0 0 0 0 0 GO:0006110 6 regulation of glycolytic process 22 23 1 1 1 0 0 0 69 23 2455 0.53022 1.0 1.0 0.0 0 0 0 0 0 GO:0006140 6 regulation of nucleotide metabolic process 30 33 1 1 1 0 0 0 69 33 2445 0.40166 1.0 1.0 0.0 0 0 0 0 0 GO:0006271 7 DNA strand elongation involved in DNA replication 6 8 1 1 1 0 0 0 69 8 2470 0.8025 1.0 1.0 0.0 0 0 0 0 0 GO:0006275 8 regulation of DNA replication 31 33 1 1 1 0 0 0 69 33 2445 0.40166 1.0 1.0 0.0 0 0 0 0 0 GO:0006308 6 DNA catabolic process 5 5 1 1 1 0 0 0 69 5 2473 0.87159 1.0 1.0 0.0 0 0 0 0 0 GO:0006397 8 mRNA processing 31 35 1 1 1 0 0 0 69 35 2443 0.37991 1.0 1.0 0.0 0 0 0 0 0 GO:0006446 8 regulation of translational initiation 12 17 1 1 1 0 0 0 69 17 2461 0.62601 1.0 1.0 0.0 0 0 0 0 0 GO:0006457 3 protein folding 33 38 1 1 1 0 0 0 69 38 2440 0.34944 1.0 0.62464 0.0 0 0 0 0 0 GO:0006458 4 'de novo' protein folding 13 17 1 1 1 0 0 0 69 17 2461 0.62601 1.0 1.0 0.0 0 0 0 0 0 GO:0006470 7 protein dephosphorylation 27 33 1 0 0 0 0 0 69 33 2445 0.40166 1.0 1.0 0.0 0 0 0 0 0 GO:0006511 8 ubiquitin-dependent protein catabolic process 65 67 1 1 1 0 0 0 69 67 2411 0.15494 1.0 0.26079 0.0 0 0 0 0 0 GO:0006521 6 regulation of cellular amino acid metabolic process 4 4 1 1 0 1 0 0 69 4 2474 0.8959 1.0 1.0 0.0 0 0 0 0 0 GO:0006606 6 protein import into nucleus 22 23 1 1 1 0 0 0 69 23 2455 0.53022 1.0 1.0 0.0 0 0 0 0 0 GO:0006644 5 phospholipid metabolic process 58 63 4 4 4 0 0 0 69 63 2415 0.17343 1.0 0.4158 0.0 0 0 0 0 0 GO:0006650 6 glycerophospholipid metabolic process 42 46 2 2 2 0 0 0 69 46 2432 0.27948 1.0 0.6354 0.0 0 0 0 0 0 GO:0006656 6 phosphatidylcholine biosynthetic process 7 7 1 1 1 0 0 0 69 7 2471 0.82491 1.0 1.0 0.0 0 0 0 0 0 GO:0006699 7 bile acid biosynthetic process 6 6 1 1 1 0 0 0 69 6 2472 0.84794 1.0 1.0 0.0 0 0 0 0 0 GO:0006702 7 androgen biosynthetic process 4 4 2 2 1 1 0 0 69 4 2474 0.8959 1.0 1.0 0.0 0 0 0 0 0 GO:0006704 6 glucocorticoid biosynthetic process 2 3 1 1 1 0 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:0006706 6 steroid catabolic process 12 14 3 3 1 2 0 0 69 14 2464 0.68011 1.0 1.0 0.0 0 0 0 0 0 GO:0006707 6 cholesterol catabolic process 4 4 1 1 1 0 0 0 69 4 2474 0.8959 1.0 1.0 0.0 0 0 0 0 0 GO:0006710 6 androgen catabolic process 4 4 1 1 0 1 0 0 69 4 2474 0.8959 1.0 1.0 0.0 0 0 0 0 0 GO:0006740 4 NADPH regeneration 4 4 1 1 1 0 0 0 69 4 2474 0.8959 1.0 1.0 0.0 0 0 0 0 0 GO:0006741 8 NADP biosynthetic process 3 3 1 1 1 0 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:0006801 5 superoxide metabolic process 12 13 2 2 0 1 0 0 69 13 2465 0.69915 1.0 1.0 0.0 0 0 0 0 0 GO:0006808 4 regulation of nitrogen utilization 3 3 1 1 0 1 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:0006825 9 copper ion transport 4 4 1 1 1 0 0 0 69 4 2474 0.8959 1.0 1.0 0.0 0 0 0 0 0 GO:0006833 6 water transport 3 3 1 1 0 1 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:0006839 5 mitochondrial transport 32 33 1 0 0 1 0 0 69 33 2445 0.40166 1.0 1.0 0.0 0 0 0 0 0 GO:0006862 7 nucleotide transport 7 7 1 0 0 1 0 0 69 7 2471 0.82491 1.0 1.0 0.0 0 0 0 0 0 GO:0006863 7 purine nucleobase transport 1 1 1 1 0 1 0 0 69 1 2477 0.97291 1.0 1.0 0.0 0 0 0 0 0 GO:0006886 5 intracellular protein transport 114 122 1 1 1 0 0 0 69 122 2356 0.032256 1.0 0.076831 0.0 0 0 0 0 0 GO:0006913 6 nucleocytoplasmic transport 37 41 1 1 1 0 0 0 69 41 2437 0.32139 1.0 0.62707 0.0 0 0 0 0 0 GO:0006977 8 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest 5 5 1 1 1 0 0 0 69 5 2473 0.87159 1.0 1.0 0.0 0 0 0 0 0 GO:0006978 8 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator 4 4 1 1 1 0 0 0 69 4 2474 0.8959 1.0 1.0 0.0 0 0 0 0 0 GO:0006986 5 response to unfolded protein 13 15 1 1 1 0 0 0 69 15 2463 0.66158 1.0 1.0 0.0 0 0 0 0 0 GO:0007015 6 actin filament organization 44 45 2 2 1 0 0 0 69 45 2433 0.28741 1.0 0.63336 0.0 0 0 0 0 0 GO:0007019 6 microtubule depolymerization 5 5 2 2 2 0 0 0 69 5 2473 0.87159 1.0 1.0 0.0 0 0 0 0 0 GO:0007026 8 negative regulation of microtubule depolymerization 9 10 1 1 1 0 0 0 69 10 2468 0.75947 1.0 1.0 0.0 0 0 0 0 0 GO:0007034 4 vacuolar transport 18 20 1 1 1 0 0 0 69 20 2458 0.57616 1.0 1.0 0.0 0 0 0 0 0 GO:0007041 5 lysosomal transport 11 13 1 1 1 0 0 0 69 13 2465 0.69915 1.0 1.0 0.0 0 0 0 0 0 GO:0007043 7 cell-cell junction assembly 20 20 2 2 1 1 0 0 69 20 2458 0.57616 1.0 1.0 0.0 0 0 0 0 0 GO:0007044 7 cell-substrate junction assembly 11 11 1 1 0 0 0 0 69 11 2467 0.73881 1.0 1.0 0.0 0 0 0 0 0 GO:0007051 6 spindle organization 29 29 4 4 4 0 0 0 69 29 2449 0.44891 1.0 1.0 0.0 0 0 0 0 0 GO:0007052 7 mitotic spindle organization 19 19 3 3 3 0 0 0 69 19 2459 0.59232 1.0 1.0 0.0 0 0 0 0 0 GO:0007064 6 mitotic sister chromatid cohesion 5 6 1 1 1 0 0 0 69 6 2472 0.84794 1.0 1.0 0.0 0 0 0 0 0 GO:0007088 7 regulation of mitotic nuclear division 43 46 3 3 3 0 0 0 69 46 2432 0.27948 1.0 0.6354 0.0 0 0 0 0 0 GO:0007094 9 mitotic spindle assembly checkpoint 9 9 1 1 1 0 0 0 69 9 2469 0.78069 1.0 1.0 0.0 0 0 0 0 0 GO:0007095 9 mitotic G2 DNA damage checkpoint 5 6 1 1 1 0 0 0 69 6 2472 0.84794 1.0 1.0 0.0 0 0 0 0 0 GO:0007099 5 centriole replication 4 4 1 1 1 0 0 0 69 4 2474 0.8959 1.0 1.0 0.0 0 0 0 0 0 GO:0007157 6 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules 7 7 1 1 1 0 0 0 69 7 2471 0.82491 1.0 1.0 0.0 0 0 0 0 0 GO:0007160 5 cell-matrix adhesion 28 28 1 1 1 0 0 0 69 28 2450 0.46155 1.0 1.0 0.0 0 0 0 0 0 GO:0007179 8 transforming growth factor beta receptor signaling pathway 27 29 1 1 1 0 0 0 69 29 2449 0.44891 1.0 1.0 0.0 0 0 0 0 0 GO:0007187 6 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger 38 39 1 1 1 0 0 0 69 39 2439 0.33983 1.0 0.62521 0.0 0 0 0 0 0 GO:0007188 7 adenylate cyclase-modulating G protein-coupled receptor signaling pathway 35 35 1 1 1 0 0 0 69 35 2443 0.37991 1.0 1.0 0.0 0 0 0 0 0 GO:0007189 8 adenylate cyclase-activating G protein-coupled receptor signaling pathway 24 24 1 1 1 0 0 0 69 24 2454 0.51572 1.0 1.0 0.0 0 0 0 0 0 GO:0007193 8 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway 13 13 1 1 1 0 0 0 69 13 2465 0.69915 1.0 1.0 0.0 0 0 0 0 0 GO:0007219 6 Notch signaling pathway 28 30 3 3 2 1 0 0 69 30 2448 0.43661 1.0 1.0 0.0 0 0 0 0 0 GO:0007229 6 integrin-mediated signaling pathway 28 29 1 1 1 0 0 0 69 29 2449 0.44891 1.0 1.0 0.0 0 0 0 0 0 GO:0007254 10 JNK cascade 9 10 1 1 0 1 0 0 69 10 2468 0.75947 1.0 1.0 0.0 0 0 0 0 0 GO:0007264 6 small GTPase mediated signal transduction 53 55 2 2 2 0 0 0 69 55 2423 0.21718 1.0 0.40255 0.0 0 0 0 0 0 GO:0007265 7 Ras protein signal transduction 42 44 2 2 2 0 0 0 69 44 2434 0.29556 1.0 0.6315 0.0 0 0 0 0 0 GO:0007281 4 germ cell development 25 25 1 1 1 0 0 0 69 25 2453 0.50162 1.0 1.0 0.0 0 0 0 0 0 GO:0007292 5 female gamete generation 2 2 1 1 1 0 0 0 69 2 2476 0.94654 1.0 1.0 0.0 0 0 0 0 0 GO:0007339 5 binding of sperm to zona pellucida 9 9 1 1 1 0 0 0 69 9 2469 0.78069 1.0 1.0 0.0 0 0 0 0 0 GO:0007389 3 pattern specification process 49 53 1 1 0 1 0 0 69 53 2425 0.22972 1.0 0.40146 0.0 0 0 0 0 0 GO:0007399 5 nervous system development 36 37 2 2 1 1 0 0 69 37 2441 0.35932 1.0 0.62434 0.0 0 0 0 0 0 GO:0007492 5 endoderm development 8 8 1 1 1 0 0 0 69 8 2470 0.8025 1.0 1.0 0.0 0 0 0 0 0 GO:0007507 5 heart development 69 74 2 2 2 0 0 0 69 74 2404 0.12714 1.0 0.26561 0.0 0 0 0 0 0 GO:0007548 4 sex differentiation 7 7 1 1 0 1 0 0 69 7 2471 0.82491 1.0 1.0 0.0 0 0 0 0 0 GO:0007565 4 female pregnancy 40 42 2 2 2 0 0 0 69 42 2436 0.31254 1.0 0.62834 0.0 0 0 0 0 0 GO:0007566 3 embryo implantation 18 18 1 1 0 1 0 0 69 18 2460 0.60894 1.0 1.0 0.0 0 0 0 0 0 GO:0007569 4 cell aging 31 33 1 1 1 0 0 0 69 33 2445 0.40166 1.0 1.0 0.0 0 0 0 0 0 GO:0007606 6 sensory perception of chemical stimulus 9 11 1 1 0 1 0 0 69 11 2467 0.73881 1.0 1.0 0.0 0 0 0 0 0 GO:0007608 7 sensory perception of smell 5 6 1 1 0 1 0 0 69 6 2472 0.84794 1.0 1.0 0.0 0 0 0 0 0 GO:0007611 5 learning or memory 75 79 2 2 2 0 0 0 69 79 2399 0.11035 1.0 0.27433 0.0 0 0 0 0 0 GO:0007612 6 learning 40 43 1 1 1 0 0 0 69 43 2435 0.30393 1.0 0.62982 0.0 0 0 0 0 0 GO:0007613 6 memory 40 41 1 1 1 0 0 0 69 41 2437 0.32139 1.0 0.62707 0.0 0 0 0 0 0 GO:0007616 7 long-term memory 11 11 1 1 1 0 0 0 69 11 2467 0.73881 1.0 1.0 0.0 0 0 0 0 0 GO:0007631 3 feeding behavior 14 16 1 1 1 0 0 0 69 16 2462 0.64355 1.0 1.0 0.0 0 0 0 0 0 GO:0007632 5 visual behavior 13 14 1 1 1 0 0 0 69 14 2464 0.68011 1.0 1.0 0.0 0 0 0 0 0 GO:0008037 3 cell recognition 38 40 1 1 1 0 0 0 69 40 2438 0.33048 1.0 0.62602 0.0 0 0 0 0 0 GO:0008206 7 bile acid metabolic process 10 11 2 2 1 1 0 0 69 11 2467 0.73881 1.0 1.0 0.0 0 0 0 0 0 GO:0008207 6 C21-steroid hormone metabolic process 8 12 2 2 1 1 0 0 69 12 2466 0.71871 1.0 1.0 0.0 0 0 0 0 0 GO:0008217 4 regulation of blood pressure 48 54 3 3 2 1 0 0 69 54 2424 0.22336 1.0 0.40188 0.0 0 0 0 0 0 GO:0008277 6 regulation of G protein-coupled receptor signaling pathway 29 29 1 1 1 0 0 0 69 29 2449 0.44891 1.0 1.0 0.0 0 0 0 0 0 GO:0008306 7 associative learning 20 22 1 1 1 0 0 0 69 22 2456 0.54512 1.0 1.0 0.0 0 0 0 0 0 GO:0008380 8 RNA splicing 20 24 1 1 1 0 0 0 69 24 2454 0.51572 1.0 1.0 0.0 0 0 0 0 0 GO:0008542 7 visual learning 11 12 1 1 1 0 0 0 69 12 2466 0.71871 1.0 1.0 0.0 0 0 0 0 0 GO:0008608 4 attachment of spindle microtubules to kinetochore 5 7 1 1 1 0 0 0 69 7 2471 0.82491 1.0 1.0 0.0 0 0 0 0 0 GO:0008626 6 granzyme-mediated apoptotic signaling pathway 3 5 1 1 0 1 0 0 69 5 2473 0.87159 1.0 1.0 0.0 0 0 0 0 0 GO:0008630 7 intrinsic apoptotic signaling pathway in response to DNA damage 37 38 3 3 2 1 0 0 69 38 2440 0.34944 1.0 0.62464 0.0 0 0 0 0 0 GO:0008643 6 carbohydrate transport 15 17 1 1 0 1 0 0 69 17 2461 0.62601 1.0 1.0 0.0 0 0 0 0 0 GO:0008654 5 phospholipid biosynthetic process 31 34 3 3 3 0 0 0 69 34 2444 0.39064 1.0 1.0 0.0 0 0 0 0 0 GO:0009051 5 pentose-phosphate shunt, oxidative branch 1 1 1 1 1 0 0 0 69 1 2477 0.97291 1.0 1.0 0.0 0 0 0 0 0 GO:0009240 6 isopentenyl diphosphate biosynthetic process 2 2 1 1 1 0 0 0 69 2 2476 0.94654 1.0 1.0 0.0 0 0 0 0 0 GO:0009306 5 protein secretion 26 28 1 1 0 1 0 0 69 28 2450 0.46155 1.0 1.0 0.0 0 0 0 0 0 GO:0009403 5 toxin biosynthetic process 1 2 1 1 0 1 0 0 69 2 2476 0.94654 1.0 1.0 0.0 0 0 0 0 0 GO:0009648 6 photoperiodism 7 8 1 1 0 1 0 0 69 8 2470 0.8025 1.0 1.0 0.0 0 0 0 0 0 GO:0009649 4 entrainment of circadian clock 7 7 1 1 0 1 0 0 69 7 2471 0.82491 1.0 1.0 0.0 0 0 0 0 0 GO:0009786 6 regulation of asymmetric cell division 1 1 1 1 1 0 0 0 69 1 2477 0.97291 1.0 1.0 0.0 0 0 0 0 0 GO:0009791 3 post-embryonic development 25 26 1 1 0 1 0 0 69 26 2452 0.4879 1.0 1.0 0.0 0 0 0 0 0 GO:0009820 5 alkaloid metabolic process 3 3 1 1 0 1 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:0009952 5 anterior/posterior pattern specification 22 26 1 1 0 1 0 0 69 26 2452 0.4879 1.0 1.0 0.0 0 0 0 0 0 GO:0009988 4 cell-cell recognition 13 13 1 1 1 0 0 0 69 13 2465 0.69915 1.0 1.0 0.0 0 0 0 0 0 GO:0010001 5 glial cell differentiation 30 32 1 1 1 0 0 0 69 32 2446 0.41299 1.0 1.0 0.0 0 0 0 0 0 GO:0010034 5 response to acetate 3 3 1 1 1 0 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:0010142 7 farnesyl diphosphate biosynthetic process, mevalonate pathway 3 3 1 1 1 0 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:0010165 6 response to X-ray 13 13 1 1 1 0 0 0 69 13 2465 0.69915 1.0 1.0 0.0 0 0 0 0 0 GO:0010224 7 response to UV-B 7 8 1 1 1 0 0 0 69 8 2470 0.8025 1.0 1.0 0.0 0 0 0 0 0 GO:0010389 8 regulation of G2/M transition of mitotic cell cycle 26 27 1 1 1 0 0 0 69 27 2451 0.47454 1.0 1.0 0.0 0 0 0 0 0 GO:0010467 5 gene expression 44 44 2 2 2 0 0 0 69 44 2434 0.29556 1.0 0.6315 0.0 0 0 0 0 0 GO:0010470 6 regulation of gastrulation 12 12 1 1 1 0 0 0 69 12 2466 0.71871 1.0 1.0 0.0 0 0 0 0 0 GO:0010498 6 proteasomal protein catabolic process 41 43 1 1 1 0 0 0 69 43 2435 0.30393 1.0 0.62982 0.0 0 0 0 0 0 GO:0010506 7 regulation of autophagy 61 65 1 1 0 1 0 0 69 65 2413 0.16393 1.0 0.42101 0.0 0 0 0 0 0 GO:0010522 5 regulation of calcium ion transport into cytosol 33 34 2 2 0 2 0 0 69 34 2444 0.39064 1.0 1.0 0.0 0 0 0 0 0 GO:0010523 5 negative regulation of calcium ion transport into cytosol 6 6 1 1 0 1 0 0 69 6 2472 0.84794 1.0 1.0 0.0 0 0 0 0 0 GO:0010524 10 positive regulation of calcium ion transport into cytosol 20 21 1 1 0 1 0 0 69 21 2457 0.56042 1.0 1.0 0.0 0 0 0 0 0 GO:0010566 7 regulation of ketone biosynthetic process 4 4 1 1 1 0 0 0 69 4 2474 0.8959 1.0 1.0 0.0 0 0 0 0 0 GO:0010611 6 regulation of cardiac muscle hypertrophy 26 26 1 1 1 0 0 0 69 26 2452 0.4879 1.0 1.0 0.0 0 0 0 0 0 GO:0010614 7 negative regulation of cardiac muscle hypertrophy 10 10 1 1 1 0 0 0 69 10 2468 0.75947 1.0 1.0 0.0 0 0 0 0 0 GO:0010638 7 positive regulation of organelle organization 145 155 4 4 3 0 0 0 69 155 2323 0.012363 1.0 0.020197 0.0 0 0 0 0 0 GO:0010656 9 negative regulation of muscle cell apoptotic process 23 27 1 1 1 0 0 0 69 27 2451 0.47454 1.0 1.0 0.0 0 0 0 0 0 GO:0010660 8 regulation of muscle cell apoptotic process 35 39 2 2 2 0 0 0 69 39 2439 0.33983 1.0 0.62521 0.0 0 0 0 0 0 GO:0010661 9 positive regulation of muscle cell apoptotic process 12 12 2 2 2 0 0 0 69 12 2466 0.71871 1.0 1.0 0.0 0 0 0 0 0 GO:0010662 9 regulation of striated muscle cell apoptotic process 18 20 2 2 2 0 0 0 69 20 2458 0.57616 1.0 1.0 0.0 0 0 0 0 0 GO:0010663 10 positive regulation of striated muscle cell apoptotic process 7 7 2 2 2 0 0 0 69 7 2471 0.82491 1.0 1.0 0.0 0 0 0 0 0 GO:0010664 10 negative regulation of striated muscle cell apoptotic process 11 13 1 1 1 0 0 0 69 13 2465 0.69915 1.0 1.0 0.0 0 0 0 0 0 GO:0010665 10 regulation of cardiac muscle cell apoptotic process 17 19 2 2 2 0 0 0 69 19 2459 0.59232 1.0 1.0 0.0 0 0 0 0 0 GO:0010666 11 positive regulation of cardiac muscle cell apoptotic process 7 7 2 2 2 0 0 0 69 7 2471 0.82491 1.0 1.0 0.0 0 0 0 0 0 GO:0010675 6 regulation of cellular carbohydrate metabolic process 47 50 3 3 2 1 0 0 69 50 2428 0.24988 1.0 0.64509 0.0 0 0 0 0 0 GO:0010677 7 negative regulation of cellular carbohydrate metabolic process 17 20 1 1 1 0 0 0 69 20 2458 0.57616 1.0 1.0 0.0 0 0 0 0 0 GO:0010713 6 negative regulation of collagen metabolic process 9 9 2 2 1 1 0 0 69 9 2469 0.78069 1.0 1.0 0.0 0 0 0 0 0 GO:0010732 8 regulation of protein glutathionylation 2 2 1 1 1 0 0 0 69 2 2476 0.94654 1.0 1.0 0.0 0 0 0 0 0 GO:0010734 9 negative regulation of protein glutathionylation 2 2 1 1 1 0 0 0 69 2 2476 0.94654 1.0 1.0 0.0 0 0 0 0 0 GO:0010769 7 regulation of cell morphogenesis involved in differentiation 72 76 1 1 1 0 0 0 69 76 2402 0.12014 1.0 0.26861 0.0 0 0 0 0 0 GO:0010770 8 positive regulation of cell morphogenesis involved in differentiation 40 44 1 1 1 0 0 0 69 44 2434 0.29556 1.0 0.6315 0.0 0 0 0 0 0 GO:0010799 9 regulation of peptidyl-threonine phosphorylation 13 15 1 1 1 0 0 0 69 15 2463 0.66158 1.0 1.0 0.0 0 0 0 0 0 GO:0010801 10 negative regulation of peptidyl-threonine phosphorylation 4 5 1 1 1 0 0 0 69 5 2473 0.87159 1.0 1.0 0.0 0 0 0 0 0 GO:0010803 7 regulation of tumor necrosis factor-mediated signaling pathway 11 11 3 3 2 1 0 0 69 11 2467 0.73881 1.0 1.0 0.0 0 0 0 0 0 GO:0010804 8 negative regulation of tumor necrosis factor-mediated signaling pathway 4 4 2 2 1 1 0 0 69 4 2474 0.8959 1.0 1.0 0.0 0 0 0 0 0 GO:0010810 6 regulation of cell-substrate adhesion 67 71 2 2 2 0 0 0 69 71 2407 0.13839 1.0 0.26241 0.0 0 0 0 0 0 GO:0010811 7 positive regulation of cell-substrate adhesion 40 43 1 1 1 0 0 0 69 43 2435 0.30393 1.0 0.62982 0.0 0 0 0 0 0 GO:0010824 8 regulation of centrosome duplication 6 7 1 1 1 0 0 0 69 7 2471 0.82491 1.0 1.0 0.0 0 0 0 0 0 GO:0010825 9 positive regulation of centrosome duplication 2 3 1 1 1 0 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:0010830 8 regulation of myotube differentiation 21 22 1 1 1 0 0 0 69 22 2456 0.54512 1.0 1.0 0.0 0 0 0 0 0 GO:0010831 9 positive regulation of myotube differentiation 11 12 1 1 1 0 0 0 69 12 2466 0.71871 1.0 1.0 0.0 0 0 0 0 0 GO:0010868 8 negative regulation of triglyceride biosynthetic process 1 1 1 1 0 1 0 0 69 1 2477 0.97291 1.0 1.0 0.0 0 0 0 0 0 GO:0010872 6 regulation of cholesterol esterification 4 4 1 1 1 0 0 0 69 4 2474 0.8959 1.0 1.0 0.0 0 0 0 0 0 GO:0010873 7 positive regulation of cholesterol esterification 4 4 1 1 1 0 0 0 69 4 2474 0.8959 1.0 1.0 0.0 0 0 0 0 0 GO:0010874 9 regulation of cholesterol efflux 9 10 2 2 2 0 0 0 69 10 2468 0.75947 1.0 1.0 0.0 0 0 0 0 0 GO:0010875 9 positive regulation of cholesterol efflux 9 9 2 2 2 0 0 0 69 9 2469 0.78069 1.0 1.0 0.0 0 0 0 0 0 GO:0010876 4 lipid localization 4 4 1 1 0 1 0 0 69 4 2474 0.8959 1.0 1.0 0.0 0 0 0 0 0 GO:0010880 7 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum 8 8 1 1 0 1 0 0 69 8 2470 0.8025 1.0 1.0 0.0 0 0 0 0 0 GO:0010887 6 negative regulation of cholesterol storage 6 6 1 1 1 0 0 0 69 6 2472 0.84794 1.0 1.0 0.0 0 0 0 0 0 GO:0010888 5 negative regulation of lipid storage 8 10 1 1 1 0 0 0 69 10 2468 0.75947 1.0 1.0 0.0 0 0 0 0 0 GO:0010898 8 positive regulation of triglyceride catabolic process 5 7 1 1 1 0 0 0 69 7 2471 0.82491 1.0 1.0 0.0 0 0 0 0 0 GO:0010906 6 regulation of glucose metabolic process 37 37 2 2 1 1 0 0 69 37 2441 0.35932 1.0 0.62434 0.0 0 0 0 0 0 GO:0010921 7 regulation of phosphatase activity 30 35 1 1 1 0 0 0 69 35 2443 0.37991 1.0 1.0 0.0 0 0 0 0 0 GO:0010948 7 negative regulation of cell cycle process 56 60 3 3 3 0 0 0 69 60 2418 0.18871 1.0 0.40931 0.0 0 0 0 0 0 GO:0010959 7 regulation of metal ion transport 108 117 3 3 1 2 0 0 69 117 2361 0.037258 1.0 0.07397 0.0 0 0 0 0 0 GO:0010965 7 regulation of mitotic sister chromatid separation 16 16 1 1 1 0 0 0 69 16 2462 0.64355 1.0 1.0 0.0 0 0 0 0 0 GO:0010968 8 regulation of microtubule nucleation 2 2 1 1 1 0 0 0 69 2 2476 0.94654 1.0 1.0 0.0 0 0 0 0 0 GO:0010972 9 negative regulation of G2/M transition of mitotic cell cycle 12 13 1 1 1 0 0 0 69 13 2465 0.69915 1.0 1.0 0.0 0 0 0 0 0 GO:0010999 6 regulation of eIF2 alpha phosphorylation by heme 1 1 1 1 1 0 0 0 69 1 2477 0.97291 1.0 1.0 0.0 0 0 0 0 0 GO:0014012 8 peripheral nervous system axon regeneration 7 7 1 1 1 0 0 0 69 7 2471 0.82491 1.0 1.0 0.0 0 0 0 0 0 GO:0014072 6 response to isoquinoline alkaloid 19 19 1 1 1 0 0 0 69 19 2459 0.59232 1.0 1.0 0.0 0 0 0 0 0 GO:0014075 6 response to amine 27 29 1 1 1 0 0 0 69 29 2449 0.44891 1.0 1.0 0.0 0 0 0 0 0 GO:0014741 6 negative regulation of muscle hypertrophy 10 10 1 1 1 0 0 0 69 10 2468 0.75947 1.0 1.0 0.0 0 0 0 0 0 GO:0014743 7 regulation of muscle hypertrophy 26 26 1 1 1 0 0 0 69 26 2452 0.4879 1.0 1.0 0.0 0 0 0 0 0 GO:0014805 5 smooth muscle adaptation 2 2 1 1 0 1 0 0 69 2 2476 0.94654 1.0 1.0 0.0 0 0 0 0 0 GO:0014895 5 smooth muscle hypertrophy 1 1 1 1 0 1 0 0 69 1 2477 0.97291 1.0 1.0 0.0 0 0 0 0 0 GO:0014896 5 muscle hypertrophy 13 14 1 1 0 1 0 0 69 14 2464 0.68011 1.0 1.0 0.0 0 0 0 0 0 GO:0015677 10 copper ion import 2 2 1 1 1 0 0 0 69 2 2476 0.94654 1.0 1.0 0.0 0 0 0 0 0 GO:0015718 8 monocarboxylic acid transport 51 54 6 6 3 3 0 0 69 54 2424 0.22336 1.0 0.40188 0.0 0 0 0 0 0 GO:0015721 7 bile acid and bile salt transport 18 18 5 5 2 3 0 0 69 18 2460 0.60894 1.0 1.0 0.0 0 0 0 0 0 GO:0015722 7 canalicular bile acid transport 4 4 2 2 0 2 0 0 69 4 2474 0.8959 1.0 1.0 0.0 0 0 0 0 0 GO:0015791 7 polyol transport 3 3 1 1 0 1 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:0015793 7 glycerol transport 3 3 1 1 0 1 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:0015837 6 amine transport 4 4 1 1 0 1 0 0 69 4 2474 0.8959 1.0 1.0 0.0 0 0 0 0 0 GO:0015840 7 urea transport 2 2 1 1 0 1 0 0 69 2 2476 0.94654 1.0 1.0 0.0 0 0 0 0 0 GO:0015849 6 organic acid transport 73 76 6 6 3 3 0 0 69 76 2402 0.12014 1.0 0.26861 0.0 0 0 0 0 0 GO:0015851 6 nucleobase transport 1 1 1 1 0 1 0 0 69 1 2477 0.97291 1.0 1.0 0.0 0 0 0 0 0 GO:0015855 7 pyrimidine nucleobase transport 1 1 1 1 0 1 0 0 69 1 2477 0.97291 1.0 1.0 0.0 0 0 0 0 0 GO:0015865 8 purine nucleotide transport 7 7 1 0 0 1 0 0 69 7 2471 0.82491 1.0 1.0 0.0 0 0 0 0 0 GO:0015867 6 ATP transport 5 5 1 0 0 1 0 0 69 5 2473 0.87159 1.0 1.0 0.0 0 0 0 0 0 GO:0015868 7 purine ribonucleotide transport 7 7 1 0 0 1 0 0 69 7 2471 0.82491 1.0 1.0 0.0 0 0 0 0 0 GO:0015908 7 fatty acid transport 24 27 1 1 1 0 0 0 69 27 2451 0.47454 1.0 1.0 0.0 0 0 0 0 0 GO:0015909 8 long-chain fatty acid transport 19 21 1 1 1 0 0 0 69 21 2457 0.56042 1.0 1.0 0.0 0 0 0 0 0 GO:0015931 6 nucleobase-containing compound transport 29 31 1 0 0 1 0 0 69 31 2447 0.42464 1.0 1.0 0.0 0 0 0 0 0 GO:0015936 7 coenzyme A metabolic process 6 6 1 1 1 0 0 0 69 6 2472 0.84794 1.0 1.0 0.0 0 0 0 0 0 GO:0015939 5 pantothenate metabolic process 1 1 1 1 0 1 0 0 69 1 2477 0.97291 1.0 1.0 0.0 0 0 0 0 0 GO:0015980 4 energy derivation by oxidation of organic compounds 29 31 1 1 0 1 0 0 69 31 2447 0.42464 1.0 1.0 0.0 0 0 0 0 0 GO:0016032 4 viral process 22 23 1 1 1 0 0 0 69 23 2455 0.53022 1.0 1.0 0.0 0 0 0 0 0 GO:0016093 5 polyprenol metabolic process 4 4 1 1 1 0 0 0 69 4 2474 0.8959 1.0 1.0 0.0 0 0 0 0 0 GO:0016094 6 polyprenol biosynthetic process 3 3 1 1 1 0 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:0016098 7 monoterpenoid metabolic process 2 3 1 1 0 1 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:0016127 6 sterol catabolic process 4 4 1 1 1 0 0 0 69 4 2474 0.8959 1.0 1.0 0.0 0 0 0 0 0 GO:0016192 4 vesicle-mediated transport 163 173 1 1 1 0 0 0 69 173 2305 0.0072856 1.0 0.013161 0.0 0 0 0 0 0 GO:0016567 9 protein ubiquitination 75 76 2 2 2 0 0 0 69 76 2402 0.12014 1.0 0.26861 0.0 0 0 0 0 0 GO:0016569 6 covalent chromatin modification 49 53 2 2 1 1 0 0 69 53 2425 0.22972 1.0 0.40146 0.0 0 0 0 0 0 GO:0016570 7 histone modification 48 51 2 2 1 1 0 0 69 51 2427 0.24297 1.0 0.40139 0.0 0 0 0 0 0 GO:0016571 7 histone methylation 12 14 1 1 0 1 0 0 69 14 2464 0.68011 1.0 1.0 0.0 0 0 0 0 0 GO:0016572 8 histone phosphorylation 12 12 1 1 1 0 0 0 69 12 2466 0.71871 1.0 1.0 0.0 0 0 0 0 0 GO:0017004 8 cytochrome complex assembly 2 3 1 1 0 1 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:0017038 6 protein import 28 30 1 1 1 0 0 0 69 30 2448 0.43661 1.0 1.0 0.0 0 0 0 0 0 GO:0017085 5 response to insecticide 12 12 1 1 1 0 0 0 69 12 2466 0.71871 1.0 1.0 0.0 0 0 0 0 0 GO:0017145 4 stem cell division 11 11 1 1 1 0 0 0 69 11 2467 0.73881 1.0 1.0 0.0 0 0 0 0 0 GO:0018195 8 peptidyl-arginine modification 3 5 1 1 0 1 0 0 69 5 2473 0.87159 1.0 1.0 0.0 0 0 0 0 0 GO:0018206 8 peptidyl-methionine modification 2 2 1 1 1 0 0 0 69 2 2476 0.94654 1.0 1.0 0.0 0 0 0 0 0 GO:0018216 8 peptidyl-arginine methylation 3 5 1 1 0 1 0 0 69 5 2473 0.87159 1.0 1.0 0.0 0 0 0 0 0 GO:0018879 6 biphenyl metabolic process 5 7 1 1 1 0 0 0 69 7 2471 0.82491 1.0 1.0 0.0 0 0 0 0 0 GO:0018916 5 nitrobenzene metabolic process 2 4 1 1 0 1 0 0 69 4 2474 0.8959 1.0 1.0 0.0 0 0 0 0 0 GO:0018958 5 phenol-containing compound metabolic process 27 31 2 2 1 1 0 0 69 31 2447 0.42464 1.0 1.0 0.0 0 0 0 0 0 GO:0018963 6 phthalate metabolic process 5 5 1 1 1 0 0 0 69 5 2473 0.87159 1.0 1.0 0.0 0 0 0 0 0 GO:0019229 7 regulation of vasoconstriction 30 31 1 1 1 0 0 0 69 31 2447 0.42464 1.0 1.0 0.0 0 0 0 0 0 GO:0019287 8 isopentenyl diphosphate biosynthetic process, mevalonate pathway 1 1 1 1 1 0 0 0 69 1 2477 0.97291 1.0 1.0 0.0 0 0 0 0 0 GO:0019321 5 pentose metabolic process 4 4 1 1 1 0 0 0 69 4 2474 0.8959 1.0 1.0 0.0 0 0 0 0 0 GO:0019322 6 pentose biosynthetic process 1 1 1 1 1 0 0 0 69 1 2477 0.97291 1.0 1.0 0.0 0 0 0 0 0 GO:0019348 6 dolichol metabolic process 3 3 1 1 1 0 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:0019408 7 dolichol biosynthetic process 2 2 1 1 1 0 0 0 69 2 2476 0.94654 1.0 1.0 0.0 0 0 0 0 0 GO:0019430 5 removal of superoxide radicals 7 7 1 1 0 0 0 0 69 7 2471 0.82491 1.0 1.0 0.0 0 0 0 0 0 GO:0019722 7 calcium-mediated signaling 32 35 1 1 1 0 0 0 69 35 2443 0.37991 1.0 1.0 0.0 0 0 0 0 0 GO:0019755 6 one-carbon compound transport 2 2 1 1 0 1 0 0 69 2 2476 0.94654 1.0 1.0 0.0 0 0 0 0 0 GO:0019827 3 stem cell population maintenance 26 27 1 1 1 0 0 0 69 27 2451 0.47454 1.0 1.0 0.0 0 0 0 0 0 GO:0019915 4 lipid storage 15 17 1 1 1 0 0 0 69 17 2461 0.62601 1.0 1.0 0.0 0 0 0 0 0 GO:0019933 8 cAMP-mediated signaling 26 27 1 1 1 0 0 0 69 27 2451 0.47454 1.0 1.0 0.0 0 0 0 0 0 GO:0019935 7 cyclic-nucleotide-mediated signaling 30 32 1 1 1 0 0 0 69 32 2446 0.41299 1.0 1.0 0.0 0 0 0 0 0 GO:0019941 7 modification-dependent protein catabolic process 67 69 1 1 1 0 0 0 69 69 2409 0.14644 1.0 0.26121 0.0 0 0 0 0 0 GO:0021766 4 hippocampus development 31 35 2 2 1 1 0 0 69 35 2443 0.37991 1.0 1.0 0.0 0 0 0 0 0 GO:0021794 4 thalamus development 1 1 1 1 0 1 0 0 69 1 2477 0.97291 1.0 1.0 0.0 0 0 0 0 0 GO:0021854 4 hypothalamus development 7 7 1 1 0 1 0 0 69 7 2471 0.82491 1.0 1.0 0.0 0 0 0 0 0 GO:0021873 6 forebrain neuroblast division 3 3 1 1 1 0 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:0021983 6 pituitary gland development 8 10 1 1 0 1 0 0 69 10 2468 0.75947 1.0 1.0 0.0 0 0 0 0 0 GO:0021987 4 cerebral cortex development 30 34 2 2 1 1 0 0 69 34 2444 0.39064 1.0 1.0 0.0 0 0 0 0 0 GO:0022406 3 membrane docking 13 14 1 1 1 0 0 0 69 14 2464 0.68011 1.0 1.0 0.0 0 0 0 0 0 GO:0022409 7 positive regulation of cell-cell adhesion 88 92 2 2 1 1 0 0 69 92 2386 0.076258 1.0 0.17753 0.0 0 0 0 0 0 GO:0022410 5 circadian sleep/wake cycle process 3 3 1 1 0 1 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:0022411 5 cellular component disassembly 46 49 3 3 3 0 0 0 69 49 2429 0.25697 1.0 0.64246 0.0 0 0 0 0 0 GO:0022600 4 digestive system process 13 13 1 1 1 0 0 0 69 13 2465 0.69915 1.0 1.0 0.0 0 0 0 0 0 GO:0022604 6 regulation of cell morphogenesis 114 118 1 1 1 0 0 0 69 118 2360 0.0362 1.0 0.074405 0.0 0 0 0 0 0 GO:0022614 4 membrane to membrane docking 3 3 1 1 1 0 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:0022616 6 DNA strand elongation 7 9 1 1 1 0 0 0 69 9 2469 0.78069 1.0 1.0 0.0 0 0 0 0 0 GO:0022898 5 regulation of transmembrane transporter activity 58 60 1 1 0 1 0 0 69 60 2418 0.18871 1.0 0.40931 0.0 0 0 0 0 0 GO:0022900 4 electron transport chain 24 26 2 2 1 1 0 0 69 26 2452 0.4879 1.0 1.0 0.0 0 0 0 0 0 GO:0023014 7 signal transduction by protein phosphorylation 49 51 2 2 1 1 0 0 69 51 2427 0.24297 1.0 0.40139 0.0 0 0 0 0 0 GO:0030031 6 cell projection assembly 41 43 2 1 1 0 0 0 69 43 2435 0.30393 1.0 0.62982 0.0 0 0 0 0 0 GO:0030071 8 regulation of mitotic metaphase/anaphase transition 15 15 1 1 1 0 0 0 69 15 2463 0.66158 1.0 1.0 0.0 0 0 0 0 0 GO:0030097 6 hemopoiesis 28 29 1 1 1 0 0 0 69 29 2449 0.44891 1.0 1.0 0.0 0 0 0 0 0 GO:0030098 5 lymphocyte differentiation 53 58 2 2 2 0 0 0 69 58 2420 0.19963 1.0 0.40595 0.0 0 0 0 0 0 GO:0030104 6 water homeostasis 14 14 1 1 1 0 0 0 69 14 2464 0.68011 1.0 1.0 0.0 0 0 0 0 0 GO:0030163 5 protein catabolic process 61 67 1 1 1 0 0 0 69 67 2411 0.15494 1.0 0.26079 0.0 0 0 0 0 0 GO:0030177 7 positive regulation of Wnt signaling pathway 26 29 1 1 1 0 0 0 69 29 2449 0.44891 1.0 1.0 0.0 0 0 0 0 0 GO:0030183 6 B cell differentiation 16 18 1 1 1 0 0 0 69 18 2460 0.60894 1.0 1.0 0.0 0 0 0 0 0 GO:0030212 7 hyaluronan metabolic process 14 14 1 1 1 0 0 0 69 14 2464 0.68011 1.0 1.0 0.0 0 0 0 0 0 GO:0030217 6 T cell differentiation 40 44 1 1 1 0 0 0 69 44 2434 0.29556 1.0 0.6315 0.0 0 0 0 0 0 GO:0030307 6 positive regulation of cell growth 47 49 1 1 0 1 0 0 69 49 2429 0.25697 1.0 0.64246 0.0 0 0 0 0 0 GO:0030330 7 DNA damage response, signal transduction by p53 class mediator 13 14 1 1 1 0 0 0 69 14 2464 0.68011 1.0 1.0 0.0 0 0 0 0 0 GO:0030509 8 BMP signaling pathway 16 16 2 2 2 0 0 0 69 16 2462 0.64355 1.0 1.0 0.0 0 0 0 0 0 GO:0030539 6 male genitalia development 5 5 1 1 0 1 0 0 69 5 2473 0.87159 1.0 1.0 0.0 0 0 0 0 0 GO:0030852 8 regulation of granulocyte differentiation 8 8 1 1 0 1 0 0 69 8 2470 0.8025 1.0 1.0 0.0 0 0 0 0 0 GO:0030853 9 negative regulation of granulocyte differentiation 5 5 1 1 0 1 0 0 69 5 2473 0.87159 1.0 1.0 0.0 0 0 0 0 0 GO:0030854 9 positive regulation of granulocyte differentiation 4 4 1 1 0 1 0 0 69 4 2474 0.8959 1.0 1.0 0.0 0 0 0 0 0 GO:0030856 6 regulation of epithelial cell differentiation 50 51 1 1 1 0 0 0 69 51 2427 0.24297 1.0 0.40139 0.0 0 0 0 0 0 GO:0030857 7 negative regulation of epithelial cell differentiation 17 17 1 1 1 0 0 0 69 17 2461 0.62601 1.0 1.0 0.0 0 0 0 0 0 GO:0030888 8 regulation of B cell proliferation 26 28 1 1 1 0 0 0 69 28 2450 0.46155 1.0 1.0 0.0 0 0 0 0 0 GO:0030890 9 positive regulation of B cell proliferation 17 19 1 1 1 0 0 0 69 19 2459 0.59232 1.0 1.0 0.0 0 0 0 0 0 GO:0031000 5 response to caffeine 17 17 1 1 0 1 0 0 69 17 2461 0.62601 1.0 1.0 0.0 0 0 0 0 0 GO:0031016 5 pancreas development 6 6 1 1 1 0 0 0 69 6 2472 0.84794 1.0 1.0 0.0 0 0 0 0 0 GO:0031018 4 endocrine pancreas development 8 8 1 1 1 0 0 0 69 8 2470 0.8025 1.0 1.0 0.0 0 0 0 0 0 GO:0031023 4 microtubule organizing center organization 13 14 1 1 1 0 0 0 69 14 2464 0.68011 1.0 1.0 0.0 0 0 0 0 0 GO:0031098 6 stress-activated protein kinase signaling cascade 26 27 1 1 0 1 0 0 69 27 2451 0.47454 1.0 1.0 0.0 0 0 0 0 0 GO:0031109 6 microtubule polymerization or depolymerization 11 11 2 2 2 0 0 0 69 11 2467 0.73881 1.0 1.0 0.0 0 0 0 0 0 GO:0031111 8 negative regulation of microtubule polymerization or depolymerization 12 13 2 2 2 0 0 0 69 13 2465 0.69915 1.0 1.0 0.0 0 0 0 0 0 GO:0031112 8 positive regulation of microtubule polymerization or depolymerization 10 10 1 1 1 0 0 0 69 10 2468 0.75947 1.0 1.0 0.0 0 0 0 0 0 GO:0031113 7 regulation of microtubule polymerization 16 17 2 2 2 0 0 0 69 17 2461 0.62601 1.0 1.0 0.0 0 0 0 0 0 GO:0031114 7 regulation of microtubule depolymerization 9 10 1 1 1 0 0 0 69 10 2468 0.75947 1.0 1.0 0.0 0 0 0 0 0 GO:0031115 8 negative regulation of microtubule polymerization 5 5 1 1 1 0 0 0 69 5 2473 0.87159 1.0 1.0 0.0 0 0 0 0 0 GO:0031116 8 positive regulation of microtubule polymerization 9 9 1 1 1 0 0 0 69 9 2469 0.78069 1.0 1.0 0.0 0 0 0 0 0 GO:0031145 9 anaphase-promoting complex-dependent catabolic process 2 2 1 1 1 0 0 0 69 2 2476 0.94654 1.0 1.0 0.0 0 0 0 0 0 GO:0031333 7 negative regulation of protein-containing complex assembly 33 37 1 1 1 0 0 0 69 37 2441 0.35932 1.0 0.62434 0.0 0 0 0 0 0 GO:0031341 5 regulation of cell killing 30 40 1 1 1 0 0 0 69 40 2438 0.33048 1.0 0.62602 0.0 0 0 0 0 0 GO:0031343 6 positive regulation of cell killing 21 30 1 1 1 0 0 0 69 30 2448 0.43661 1.0 1.0 0.0 0 0 0 0 0 GO:0031398 10 positive regulation of protein ubiquitination 34 35 2 2 1 1 0 0 69 35 2443 0.37991 1.0 1.0 0.0 0 0 0 0 0 GO:0031572 9 G2 DNA damage checkpoint 5 6 1 1 1 0 0 0 69 6 2472 0.84794 1.0 1.0 0.0 0 0 0 0 0 GO:0031577 7 spindle checkpoint 9 9 1 1 1 0 0 0 69 9 2469 0.78069 1.0 1.0 0.0 0 0 0 0 0 GO:0031581 8 hemidesmosome assembly 2 2 1 1 0 0 0 0 69 2 2476 0.94654 1.0 1.0 0.0 0 0 0 0 0 GO:0031589 4 cell-substrate adhesion 43 44 2 2 1 0 0 0 69 44 2434 0.29556 1.0 0.6315 0.0 0 0 0 0 0 GO:0031647 4 regulation of protein stability 60 71 2 2 2 0 0 0 69 71 2407 0.13839 1.0 0.26241 0.0 0 0 0 0 0 GO:0031664 6 regulation of lipopolysaccharide-mediated signaling pathway 8 9 1 1 0 1 0 0 69 9 2469 0.78069 1.0 1.0 0.0 0 0 0 0 0 GO:0031665 7 negative regulation of lipopolysaccharide-mediated signaling pathway 3 3 1 1 0 1 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:0031915 6 positive regulation of synaptic plasticity 6 6 1 1 1 0 0 0 69 6 2472 0.84794 1.0 1.0 0.0 0 0 0 0 0 GO:0032006 7 regulation of TOR signaling 19 20 1 1 1 0 0 0 69 20 2458 0.57616 1.0 1.0 0.0 0 0 0 0 0 GO:0032007 8 negative regulation of TOR signaling 11 11 1 1 1 0 0 0 69 11 2467 0.73881 1.0 1.0 0.0 0 0 0 0 0 GO:0032069 6 regulation of nuclease activity 9 10 1 1 1 0 0 0 69 10 2468 0.75947 1.0 1.0 0.0 0 0 0 0 0 GO:0032075 7 positive regulation of nuclease activity 6 6 1 1 1 0 0 0 69 6 2472 0.84794 1.0 1.0 0.0 0 0 0 0 0 GO:0032091 6 negative regulation of protein binding 41 42 2 2 2 0 0 0 69 42 2436 0.31254 1.0 0.62834 0.0 0 0 0 0 0 GO:0032092 6 positive regulation of protein binding 30 33 1 1 0 1 0 0 69 33 2445 0.40166 1.0 1.0 0.0 0 0 0 0 0 GO:0032231 6 regulation of actin filament bundle assembly 27 30 3 3 2 0 0 0 69 30 2448 0.43661 1.0 1.0 0.0 0 0 0 0 0 GO:0032232 7 negative regulation of actin filament bundle assembly 4 4 1 1 1 0 0 0 69 4 2474 0.8959 1.0 1.0 0.0 0 0 0 0 0 GO:0032233 7 positive regulation of actin filament bundle assembly 21 24 2 2 1 0 0 0 69 24 2454 0.51572 1.0 1.0 0.0 0 0 0 0 0 GO:0032271 7 regulation of protein polymerization 48 52 2 2 2 0 0 0 69 52 2426 0.23625 1.0 0.40129 0.0 0 0 0 0 0 GO:0032272 8 negative regulation of protein polymerization 14 16 1 1 1 0 0 0 69 16 2462 0.64355 1.0 1.0 0.0 0 0 0 0 0 GO:0032273 8 positive regulation of protein polymerization 27 30 1 1 1 0 0 0 69 30 2448 0.43661 1.0 1.0 0.0 0 0 0 0 0 GO:0032350 5 regulation of hormone metabolic process 23 24 2 2 2 0 0 0 69 24 2454 0.51572 1.0 1.0 0.0 0 0 0 0 0 GO:0032352 6 positive regulation of hormone metabolic process 18 19 2 2 2 0 0 0 69 19 2459 0.59232 1.0 1.0 0.0 0 0 0 0 0 GO:0032370 6 positive regulation of lipid transport 26 28 3 3 3 0 0 0 69 28 2450 0.46155 1.0 1.0 0.0 0 0 0 0 0 GO:0032373 7 positive regulation of sterol transport 12 12 3 3 3 0 0 0 69 12 2466 0.71871 1.0 1.0 0.0 0 0 0 0 0 GO:0032376 8 positive regulation of cholesterol transport 12 12 3 3 3 0 0 0 69 12 2466 0.71871 1.0 1.0 0.0 0 0 0 0 0 GO:0032388 6 positive regulation of intracellular transport 64 68 1 1 1 0 0 0 69 68 2410 0.15063 1.0 0.2609 0.0 0 0 0 0 0 GO:0032409 4 regulation of transporter activity 61 63 1 1 0 1 0 0 69 63 2415 0.17343 1.0 0.4158 0.0 0 0 0 0 0 GO:0032410 5 negative regulation of transporter activity 14 15 1 1 0 1 0 0 69 15 2463 0.66158 1.0 1.0 0.0 0 0 0 0 0 GO:0032411 5 positive regulation of transporter activity 27 28 1 1 0 1 0 0 69 28 2450 0.46155 1.0 1.0 0.0 0 0 0 0 0 GO:0032412 6 regulation of ion transmembrane transporter activity 53 55 1 1 0 1 0 0 69 55 2423 0.21718 1.0 0.40255 0.0 0 0 0 0 0 GO:0032413 6 negative regulation of ion transmembrane transporter activity 12 13 1 1 0 1 0 0 69 13 2465 0.69915 1.0 1.0 0.0 0 0 0 0 0 GO:0032414 6 positive regulation of ion transmembrane transporter activity 24 25 1 1 0 1 0 0 69 25 2453 0.50162 1.0 1.0 0.0 0 0 0 0 0 GO:0032446 8 protein modification by small protein conjugation 82 83 2 2 2 0 0 0 69 83 2395 0.098511 1.0 0.17038 0.0 0 0 0 0 0 GO:0032465 6 regulation of cytokinesis 27 28 3 3 3 0 0 0 69 28 2450 0.46155 1.0 1.0 0.0 0 0 0 0 0 GO:0032467 7 positive regulation of cytokinesis 11 12 1 1 1 0 0 0 69 12 2466 0.71871 1.0 1.0 0.0 0 0 0 0 0 GO:0032613 6 interleukin-10 production 3 3 1 1 1 0 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:0032615 6 interleukin-12 production 2 2 1 1 1 0 0 0 69 2 2476 0.94654 1.0 1.0 0.0 0 0 0 0 0 GO:0032663 6 regulation of interleukin-2 production 17 18 1 1 0 1 0 0 69 18 2460 0.60894 1.0 1.0 0.0 0 0 0 0 0 GO:0032677 6 regulation of interleukin-8 production 31 32 1 1 1 0 0 0 69 32 2446 0.41299 1.0 1.0 0.0 0 0 0 0 0 GO:0032689 7 negative regulation of interferon-gamma production 7 7 1 1 0 1 0 0 69 7 2471 0.82491 1.0 1.0 0.0 0 0 0 0 0 GO:0032703 7 negative regulation of interleukin-2 production 7 7 1 1 0 1 0 0 69 7 2471 0.82491 1.0 1.0 0.0 0 0 0 0 0 GO:0032757 7 positive regulation of interleukin-8 production 25 26 1 1 1 0 0 0 69 26 2452 0.4879 1.0 1.0 0.0 0 0 0 0 0 GO:0032874 8 positive regulation of stress-activated MAPK cascade 40 44 1 1 1 0 0 0 69 44 2434 0.29556 1.0 0.6315 0.0 0 0 0 0 0 GO:0032890 6 regulation of organic acid transport 33 35 3 3 2 1 0 0 69 35 2443 0.37991 1.0 1.0 0.0 0 0 0 0 0 GO:0032944 7 regulation of mononuclear cell proliferation 75 80 2 2 2 0 0 0 69 80 2398 0.10727 1.0 0.27655 0.0 0 0 0 0 0 GO:0032946 8 positive regulation of mononuclear cell proliferation 48 52 2 2 2 0 0 0 69 52 2426 0.23625 1.0 0.40129 0.0 0 0 0 0 0 GO:0032954 7 regulation of cytokinetic process 3 3 1 1 1 0 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:0032956 6 regulation of actin cytoskeleton organization 79 82 4 4 3 0 0 0 69 82 2396 0.10135 1.0 0.17028 0.0 0 0 0 0 0 GO:0032966 7 negative regulation of collagen biosynthetic process 9 9 2 2 1 1 0 0 69 9 2469 0.78069 1.0 1.0 0.0 0 0 0 0 0 GO:0032970 5 regulation of actin filament-based process 88 91 4 4 3 0 0 0 69 91 2387 0.078462 1.0 0.1762 0.0 0 0 0 0 0 GO:0032984 6 protein-containing complex disassembly 18 21 3 3 3 0 0 0 69 21 2457 0.56042 1.0 1.0 0.0 0 0 0 0 0 GO:0033032 8 regulation of myeloid cell apoptotic process 13 15 1 1 1 0 0 0 69 15 2463 0.66158 1.0 1.0 0.0 0 0 0 0 0 GO:0033033 9 negative regulation of myeloid cell apoptotic process 7 8 1 1 1 0 0 0 69 8 2470 0.8025 1.0 1.0 0.0 0 0 0 0 0 GO:0033045 6 regulation of sister chromatid segregation 20 21 1 1 1 0 0 0 69 21 2457 0.56042 1.0 1.0 0.0 0 0 0 0 0 GO:0033046 7 negative regulation of sister chromatid segregation 12 12 1 1 1 0 0 0 69 12 2466 0.71871 1.0 1.0 0.0 0 0 0 0 0 GO:0033047 7 regulation of mitotic sister chromatid segregation 18 18 1 1 1 0 0 0 69 18 2460 0.60894 1.0 1.0 0.0 0 0 0 0 0 GO:0033048 8 negative regulation of mitotic sister chromatid segregation 12 12 1 1 1 0 0 0 69 12 2466 0.71871 1.0 1.0 0.0 0 0 0 0 0 GO:0033081 9 regulation of T cell differentiation in thymus 7 8 1 1 0 1 0 0 69 8 2470 0.8025 1.0 1.0 0.0 0 0 0 0 0 GO:0033089 10 positive regulation of T cell differentiation in thymus 4 4 1 1 0 1 0 0 69 4 2474 0.8959 1.0 1.0 0.0 0 0 0 0 0 GO:0033120 8 positive regulation of RNA splicing 7 8 1 1 1 0 0 0 69 8 2470 0.8025 1.0 1.0 0.0 0 0 0 0 0 GO:0033135 9 regulation of peptidyl-serine phosphorylation 38 46 1 1 1 0 0 0 69 46 2432 0.27948 1.0 0.6354 0.0 0 0 0 0 0 GO:0033137 10 negative regulation of peptidyl-serine phosphorylation 12 12 1 1 1 0 0 0 69 12 2466 0.71871 1.0 1.0 0.0 0 0 0 0 0 GO:0033233 9 regulation of protein sumoylation 9 9 1 1 1 0 0 0 69 9 2469 0.78069 1.0 1.0 0.0 0 0 0 0 0 GO:0033238 6 regulation of cellular amine metabolic process 12 13 1 1 0 1 0 0 69 13 2465 0.69915 1.0 1.0 0.0 0 0 0 0 0 GO:0033240 7 positive regulation of cellular amine metabolic process 5 6 1 1 0 1 0 0 69 6 2472 0.84794 1.0 1.0 0.0 0 0 0 0 0 GO:0033327 4 Leydig cell differentiation 8 9 1 1 1 0 0 0 69 9 2469 0.78069 1.0 1.0 0.0 0 0 0 0 0 GO:0033561 5 regulation of water loss via skin 8 8 1 1 1 0 0 0 69 8 2470 0.8025 1.0 1.0 0.0 0 0 0 0 0 GO:0033574 5 response to testosterone 28 31 1 1 0 1 0 0 69 31 2447 0.42464 1.0 1.0 0.0 0 0 0 0 0 GO:0033594 6 response to hydroxyisoflavone 6 6 1 1 0 1 0 0 69 6 2472 0.84794 1.0 1.0 0.0 0 0 0 0 0 GO:0033595 5 response to genistein 5 5 1 1 0 1 0 0 69 5 2473 0.87159 1.0 1.0 0.0 0 0 0 0 0 GO:0033762 6 response to glucagon 17 18 1 1 1 0 0 0 69 18 2460 0.60894 1.0 1.0 0.0 0 0 0 0 0 GO:0033860 6 regulation of NAD(P)H oxidase activity 3 3 1 1 0 1 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:0033864 7 positive regulation of NAD(P)H oxidase activity 2 2 1 1 0 1 0 0 69 2 2476 0.94654 1.0 1.0 0.0 0 0 0 0 0 GO:0034113 5 heterotypic cell-cell adhesion 7 7 1 1 1 0 0 0 69 7 2471 0.82491 1.0 1.0 0.0 0 0 0 0 0 GO:0034114 7 regulation of heterotypic cell-cell adhesion 12 13 1 1 1 0 0 0 69 13 2465 0.69915 1.0 1.0 0.0 0 0 0 0 0 GO:0034115 8 negative regulation of heterotypic cell-cell adhesion 4 4 1 1 1 0 0 0 69 4 2474 0.8959 1.0 1.0 0.0 0 0 0 0 0 GO:0034123 8 positive regulation of toll-like receptor signaling pathway 7 7 1 1 0 1 0 0 69 7 2471 0.82491 1.0 1.0 0.0 0 0 0 0 0 GO:0034135 8 regulation of toll-like receptor 2 signaling pathway 3 3 1 1 0 1 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:0034137 9 positive regulation of toll-like receptor 2 signaling pathway 2 2 1 1 0 1 0 0 69 2 2476 0.94654 1.0 1.0 0.0 0 0 0 0 0 GO:0034142 7 toll-like receptor 4 signaling pathway 6 6 1 1 0 1 0 0 69 6 2472 0.84794 1.0 1.0 0.0 0 0 0 0 0 GO:0034162 7 toll-like receptor 9 signaling pathway 2 2 1 1 0 1 0 0 69 2 2476 0.94654 1.0 1.0 0.0 0 0 0 0 0 GO:0034198 6 cellular response to amino acid starvation 13 15 1 1 1 0 0 0 69 15 2463 0.66158 1.0 1.0 0.0 0 0 0 0 0 GO:0034255 6 regulation of urea metabolic process 1 1 1 1 0 1 0 0 69 1 2477 0.97291 1.0 1.0 0.0 0 0 0 0 0 GO:0034329 6 cell junction assembly 40 41 3 3 1 1 0 0 69 41 2437 0.32139 1.0 0.62707 0.0 0 0 0 0 0 GO:0034349 6 glial cell apoptotic process 8 9 1 1 0 1 0 0 69 9 2469 0.78069 1.0 1.0 0.0 0 0 0 0 0 GO:0034377 7 plasma lipoprotein particle assembly 7 7 2 2 2 0 0 0 69 7 2471 0.82491 1.0 1.0 0.0 0 0 0 0 0 GO:0034379 8 very-low-density lipoprotein particle assembly 3 3 1 1 1 0 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:0034380 8 high-density lipoprotein particle assembly 4 4 1 1 1 0 0 0 69 4 2474 0.8959 1.0 1.0 0.0 0 0 0 0 0 GO:0034465 5 response to carbon monoxide 5 6 1 1 1 0 0 0 69 6 2472 0.84794 1.0 1.0 0.0 0 0 0 0 0 GO:0034504 7 protein localization to nucleus 39 40 1 1 1 0 0 0 69 40 2438 0.33048 1.0 0.62602 0.0 0 0 0 0 0 GO:0034620 6 cellular response to unfolded protein 10 12 1 1 1 0 0 0 69 12 2466 0.71871 1.0 1.0 0.0 0 0 0 0 0 GO:0034644 7 cellular response to UV 32 34 2 2 1 1 0 0 69 34 2444 0.39064 1.0 1.0 0.0 0 0 0 0 0 GO:0034755 8 iron ion transmembrane transport 4 4 1 1 1 0 0 0 69 4 2474 0.8959 1.0 1.0 0.0 0 0 0 0 0 GO:0034764 6 positive regulation of transmembrane transport 60 63 2 2 1 1 0 0 69 63 2415 0.17343 1.0 0.4158 0.0 0 0 0 0 0 GO:0034765 6 regulation of ion transmembrane transport 95 99 3 3 1 2 0 0 69 99 2379 0.062447 1.0 0.11166 0.0 0 0 0 0 0 GO:0034766 7 negative regulation of ion transmembrane transport 20 22 1 1 0 1 0 0 69 22 2456 0.54512 1.0 1.0 0.0 0 0 0 0 0 GO:0034767 7 positive regulation of ion transmembrane transport 41 43 2 2 1 1 0 0 69 43 2435 0.30393 1.0 0.62982 0.0 0 0 0 0 0 GO:0034969 8 histone arginine methylation 2 3 1 1 0 1 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:0034971 9 histone H3-R17 methylation 1 1 1 1 0 1 0 0 69 1 2477 0.97291 1.0 1.0 0.0 0 0 0 0 0 GO:0034976 5 response to endoplasmic reticulum stress 55 58 1 1 0 1 0 0 69 58 2420 0.19963 1.0 0.40595 0.0 0 0 0 0 0 GO:0035024 10 negative regulation of Rho protein signal transduction 3 3 1 1 1 0 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:0035025 10 positive regulation of Rho protein signal transduction 9 9 1 1 1 0 0 0 69 9 2469 0.78069 1.0 1.0 0.0 0 0 0 0 0 GO:0035036 4 sperm-egg recognition 9 9 1 1 1 0 0 0 69 9 2469 0.78069 1.0 1.0 0.0 0 0 0 0 0 GO:0035051 5 cardiocyte differentiation 10 10 1 1 1 0 0 0 69 10 2468 0.75947 1.0 1.0 0.0 0 0 0 0 0 GO:0035303 8 regulation of dephosphorylation 40 45 1 1 1 0 0 0 69 45 2433 0.28741 1.0 0.63336 0.0 0 0 0 0 0 GO:0035304 8 regulation of protein dephosphorylation 25 28 1 1 1 0 0 0 69 28 2450 0.46155 1.0 1.0 0.0 0 0 0 0 0 GO:0035335 8 peptidyl-tyrosine dephosphorylation 16 20 1 0 0 0 0 0 69 20 2458 0.57616 1.0 1.0 0.0 0 0 0 0 0 GO:0035356 6 cellular triglyceride homeostasis 3 3 1 1 0 1 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:0035376 8 sterol import 4 4 1 1 1 0 0 0 69 4 2474 0.8959 1.0 1.0 0.0 0 0 0 0 0 GO:0035584 8 calcium-mediated signaling using intracellular calcium source 6 6 1 1 1 0 0 0 69 6 2472 0.84794 1.0 1.0 0.0 0 0 0 0 0 GO:0035592 5 establishment of protein localization to extracellular region 27 29 1 1 0 1 0 0 69 29 2449 0.44891 1.0 1.0 0.0 0 0 0 0 0 GO:0035634 6 response to stilbenoid 13 15 1 1 0 1 0 0 69 15 2463 0.66158 1.0 1.0 0.0 0 0 0 0 0 GO:0035774 7 positive regulation of insulin secretion involved in cellular response to glucose stimulus 13 13 1 1 0 1 0 0 69 13 2465 0.69915 1.0 1.0 0.0 0 0 0 0 0 GO:0035860 8 glial cell-derived neurotrophic factor receptor signaling pathway 2 2 1 1 1 0 0 0 69 2 2476 0.94654 1.0 1.0 0.0 0 0 0 0 0 GO:0035914 5 skeletal muscle cell differentiation 14 15 1 1 1 0 0 0 69 15 2463 0.66158 1.0 1.0 0.0 0 0 0 0 0 GO:0035924 7 cellular response to vascular endothelial growth factor stimulus 17 17 1 1 1 0 0 0 69 17 2461 0.62601 1.0 1.0 0.0 0 0 0 0 0 GO:0035966 4 response to topologically incorrect protein 16 19 1 1 1 0 0 0 69 19 2459 0.59232 1.0 1.0 0.0 0 0 0 0 0 GO:0035967 5 cellular response to topologically incorrect protein 11 14 1 1 1 0 0 0 69 14 2464 0.68011 1.0 1.0 0.0 0 0 0 0 0 GO:0036146 6 cellular response to mycotoxin 3 3 1 1 1 0 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:0036270 5 response to diuretic 17 17 1 1 0 1 0 0 69 17 2461 0.62601 1.0 1.0 0.0 0 0 0 0 0 GO:0036294 6 cellular response to decreased oxygen levels 61 64 2 2 2 0 0 0 69 64 2414 0.16861 1.0 0.41832 0.0 0 0 0 0 0 GO:0036295 6 cellular response to increased oxygen levels 7 7 1 1 1 0 0 0 69 7 2471 0.82491 1.0 1.0 0.0 0 0 0 0 0 GO:0038179 6 neurotrophin signaling pathway 9 10 1 1 1 0 0 0 69 10 2468 0.75947 1.0 1.0 0.0 0 0 0 0 0 GO:0038185 6 intracellular bile acid receptor signaling pathway 1 1 1 1 0 1 0 0 69 1 2477 0.97291 1.0 1.0 0.0 0 0 0 0 0 GO:0040001 7 establishment of mitotic spindle localization 10 10 1 1 1 0 0 0 69 10 2468 0.75947 1.0 1.0 0.0 0 0 0 0 0 GO:0040014 5 regulation of multicellular organism growth 21 24 3 3 3 0 0 0 69 24 2454 0.51572 1.0 1.0 0.0 0 0 0 0 0 GO:0040015 6 negative regulation of multicellular organism growth 5 6 2 2 2 0 0 0 69 6 2472 0.84794 1.0 1.0 0.0 0 0 0 0 0 GO:0040020 6 regulation of meiotic nuclear division 5 5 1 1 1 0 0 0 69 5 2473 0.87159 1.0 1.0 0.0 0 0 0 0 0 GO:0042026 4 protein refolding 7 9 1 1 1 0 0 0 69 9 2469 0.78069 1.0 1.0 0.0 0 0 0 0 0 GO:0042035 6 regulation of cytokine biosynthetic process 40 43 1 1 1 0 0 0 69 43 2435 0.30393 1.0 0.62982 0.0 0 0 0 0 0 GO:0042044 5 fluid transport 6 6 1 1 0 1 0 0 69 6 2472 0.84794 1.0 1.0 0.0 0 0 0 0 0 GO:0042102 9 positive regulation of T cell proliferation 34 36 1 1 1 0 0 0 69 36 2442 0.36948 1.0 0.62432 0.0 0 0 0 0 0 GO:0042108 7 positive regulation of cytokine biosynthetic process 31 34 1 1 1 0 0 0 69 34 2444 0.39064 1.0 1.0 0.0 0 0 0 0 0 GO:0042113 5 B cell activation 34 36 1 1 1 0 0 0 69 36 2442 0.36948 1.0 0.62432 0.0 0 0 0 0 0 GO:0042129 8 regulation of T cell proliferation 55 58 1 1 1 0 0 0 69 58 2420 0.19963 1.0 0.40595 0.0 0 0 0 0 0 GO:0042158 6 lipoprotein biosynthetic process 3 3 1 1 1 0 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:0042177 7 negative regulation of protein catabolic process 37 38 2 2 2 0 0 0 69 38 2440 0.34944 1.0 0.62464 0.0 0 0 0 0 0 GO:0042220 5 response to cocaine 23 24 2 2 2 0 0 0 69 24 2454 0.51572 1.0 1.0 0.0 0 0 0 0 0 GO:0042306 8 regulation of protein import into nucleus 30 33 1 1 1 0 0 0 69 33 2445 0.40166 1.0 1.0 0.0 0 0 0 0 0 GO:0042307 8 positive regulation of protein import into nucleus 21 22 1 1 1 0 0 0 69 22 2456 0.54512 1.0 1.0 0.0 0 0 0 0 0 GO:0042310 8 vasoconstriction 6 7 1 1 1 0 0 0 69 7 2471 0.82491 1.0 1.0 0.0 0 0 0 0 0 GO:0042428 5 serotonin metabolic process 5 6 1 1 0 1 0 0 69 6 2472 0.84794 1.0 1.0 0.0 0 0 0 0 0 GO:0042446 5 hormone biosynthetic process 12 15 2 2 1 1 0 0 69 15 2463 0.66158 1.0 1.0 0.0 0 0 0 0 0 GO:0042447 5 hormone catabolic process 7 11 1 1 0 1 0 0 69 11 2467 0.73881 1.0 1.0 0.0 0 0 0 0 0 GO:0042448 7 progesterone metabolic process 5 7 2 2 1 1 0 0 69 7 2471 0.82491 1.0 1.0 0.0 0 0 0 0 0 GO:0042554 6 superoxide anion generation 6 6 1 1 0 1 0 0 69 6 2472 0.84794 1.0 1.0 0.0 0 0 0 0 0 GO:0042738 6 exogenous drug catabolic process 17 20 1 1 0 1 0 0 69 20 2458 0.57616 1.0 1.0 0.0 0 0 0 0 0 GO:0042747 6 circadian sleep/wake cycle, REM sleep 3 3 1 1 0 1 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:0042755 4 eating behavior 5 6 1 1 1 0 0 0 69 6 2472 0.84794 1.0 1.0 0.0 0 0 0 0 0 GO:0042770 6 signal transduction in response to DNA damage 22 24 2 2 1 1 0 0 69 24 2454 0.51572 1.0 1.0 0.0 0 0 0 0 0 GO:0042771 8 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 12 12 2 2 2 0 0 0 69 12 2466 0.71871 1.0 1.0 0.0 0 0 0 0 0 GO:0042772 7 DNA damage response, signal transduction resulting in transcription 4 4 1 1 1 0 0 0 69 4 2474 0.8959 1.0 1.0 0.0 0 0 0 0 0 GO:0043087 6 regulation of GTPase activity 76 81 1 1 1 0 0 0 69 81 2397 0.10427 1.0 0.17034 0.0 0 0 0 0 0 GO:0043153 5 entrainment of circadian clock by photoperiod 7 7 1 1 0 1 0 0 69 7 2471 0.82491 1.0 1.0 0.0 0 0 0 0 0 GO:0043161 8 proteasome-mediated ubiquitin-dependent protein catabolic process 39 40 1 1 1 0 0 0 69 40 2438 0.33048 1.0 0.62602 0.0 0 0 0 0 0 GO:0043242 7 negative regulation of protein-containing complex disassembly 13 15 1 1 1 0 0 0 69 15 2463 0.66158 1.0 1.0 0.0 0 0 0 0 0 GO:0043244 6 regulation of protein-containing complex disassembly 19 21 1 1 1 0 0 0 69 21 2457 0.56042 1.0 1.0 0.0 0 0 0 0 0 GO:0043249 5 erythrocyte maturation 1 1 1 1 1 0 0 0 69 1 2477 0.97291 1.0 1.0 0.0 0 0 0 0 0 GO:0043252 7 sodium-independent organic anion transport 7 7 1 1 1 0 0 0 69 7 2471 0.82491 1.0 1.0 0.0 0 0 0 0 0 GO:0043269 6 regulation of ion transport 174 184 7 7 4 3 0 0 69 184 2294 0.0052633 1.0 0.008478 0.0 0 0 0 0 0 GO:0043270 6 positive regulation of ion transport 88 94 3 3 2 1 0 0 69 94 2384 0.072031 1.0 0.18056 0.0 0 0 0 0 0 GO:0043271 6 negative regulation of ion transport 40 43 1 1 0 1 0 0 69 43 2435 0.30393 1.0 0.62982 0.0 0 0 0 0 0 GO:0043279 6 response to alkaloid 71 74 3 3 2 1 0 0 69 74 2404 0.12714 1.0 0.26561 0.0 0 0 0 0 0 GO:0043393 5 regulation of protein binding 73 77 3 3 2 1 0 0 69 77 2401 0.11679 1.0 0.27036 0.0 0 0 0 0 0 GO:0043470 6 regulation of carbohydrate catabolic process 24 25 1 1 1 0 0 0 69 25 2453 0.50162 1.0 1.0 0.0 0 0 0 0 0 GO:0043484 7 regulation of RNA splicing 21 23 1 1 1 0 0 0 69 23 2455 0.53022 1.0 1.0 0.0 0 0 0 0 0 GO:0043500 4 muscle adaptation 14 14 1 1 0 1 0 0 69 14 2464 0.68011 1.0 1.0 0.0 0 0 0 0 0 GO:0043502 5 regulation of muscle adaptation 33 33 1 1 1 0 0 0 69 33 2445 0.40166 1.0 1.0 0.0 0 0 0 0 0 GO:0043525 8 positive regulation of neuron apoptotic process 36 38 3 3 1 1 0 0 69 38 2440 0.34944 1.0 0.62464 0.0 0 0 0 0 0 GO:0043547 7 positive regulation of GTPase activity 63 68 1 1 1 0 0 0 69 68 2410 0.15063 1.0 0.2609 0.0 0 0 0 0 0 GO:0043550 7 regulation of lipid kinase activity 23 23 2 2 2 0 0 0 69 23 2455 0.53022 1.0 1.0 0.0 0 0 0 0 0 GO:0043551 8 regulation of phosphatidylinositol 3-kinase activity 18 18 1 1 1 0 0 0 69 18 2460 0.60894 1.0 1.0 0.0 0 0 0 0 0 GO:0043567 6 regulation of insulin-like growth factor receptor signaling pathway 8 8 1 1 1 0 0 0 69 8 2470 0.8025 1.0 1.0 0.0 0 0 0 0 0 GO:0043568 7 positive regulation of insulin-like growth factor receptor signaling pathway 5 5 1 1 1 0 0 0 69 5 2473 0.87159 1.0 1.0 0.0 0 0 0 0 0 GO:0043618 8 regulation of transcription from RNA polymerase II promoter in response to stress 23 25 2 2 2 0 0 0 69 25 2453 0.50162 1.0 1.0 0.0 0 0 0 0 0 GO:0043620 7 regulation of DNA-templated transcription in response to stress 24 26 2 2 2 0 0 0 69 26 2452 0.4879 1.0 1.0 0.0 0 0 0 0 0 GO:0043624 7 cellular protein complex disassembly 9 11 2 2 2 0 0 0 69 11 2467 0.73881 1.0 1.0 0.0 0 0 0 0 0 GO:0043632 6 modification-dependent macromolecule catabolic process 69 71 1 1 1 0 0 0 69 71 2407 0.13839 1.0 0.26241 0.0 0 0 0 0 0 GO:0043666 7 regulation of phosphoprotein phosphatase activity 19 22 1 1 1 0 0 0 69 22 2456 0.54512 1.0 1.0 0.0 0 0 0 0 0 GO:0043691 9 reverse cholesterol transport 7 7 2 2 2 0 0 0 69 7 2471 0.82491 1.0 1.0 0.0 0 0 0 0 0 GO:0044070 7 regulation of anion transport 43 45 4 4 3 1 0 0 69 45 2433 0.28741 1.0 0.63336 0.0 0 0 0 0 0 GO:0044320 6 cellular response to leptin stimulus 5 5 1 1 1 0 0 0 69 5 2473 0.87159 1.0 1.0 0.0 0 0 0 0 0 GO:0044321 5 response to leptin 8 9 1 1 1 0 0 0 69 9 2469 0.78069 1.0 1.0 0.0 0 0 0 0 0 GO:0044342 5 type B pancreatic cell proliferation 4 4 1 1 1 0 0 0 69 4 2474 0.8959 1.0 1.0 0.0 0 0 0 0 0 GO:0044403 3 symbiotic process 38 40 1 1 1 0 0 0 69 40 2438 0.33048 1.0 0.62602 0.0 0 0 0 0 0 GO:0044550 4 secondary metabolite biosynthetic process 1 2 1 1 0 1 0 0 69 2 2476 0.94654 1.0 1.0 0.0 0 0 0 0 0 GO:0044773 9 mitotic DNA damage checkpoint 13 14 1 1 1 0 0 0 69 14 2464 0.68011 1.0 1.0 0.0 0 0 0 0 0 GO:0044782 6 cilium organization 18 19 2 1 1 0 0 0 69 19 2459 0.59232 1.0 1.0 0.0 0 0 0 0 0 GO:0044818 8 mitotic G2/M transition checkpoint 9 10 1 1 1 0 0 0 69 10 2468 0.75947 1.0 1.0 0.0 0 0 0 0 0 GO:0044839 5 cell cycle G2/M phase transition 18 18 2 2 2 0 0 0 69 18 2460 0.60894 1.0 1.0 0.0 0 0 0 0 0 GO:0045071 7 negative regulation of viral genome replication 17 18 1 1 1 0 0 0 69 18 2460 0.60894 1.0 1.0 0.0 0 0 0 0 0 GO:0045073 7 regulation of chemokine biosynthetic process 8 10 1 1 1 0 0 0 69 10 2468 0.75947 1.0 1.0 0.0 0 0 0 0 0 GO:0045080 8 positive regulation of chemokine biosynthetic process 7 9 1 1 1 0 0 0 69 9 2469 0.78069 1.0 1.0 0.0 0 0 0 0 0 GO:0045132 4 meiotic chromosome segregation 8 8 1 1 1 0 0 0 69 8 2470 0.8025 1.0 1.0 0.0 0 0 0 0 0 GO:0045165 4 cell fate commitment 32 33 1 1 1 0 0 0 69 33 2445 0.40166 1.0 1.0 0.0 0 0 0 0 0 GO:0045216 6 cell-cell junction organization 33 33 2 2 1 1 0 0 69 33 2445 0.40166 1.0 1.0 0.0 0 0 0 0 0 GO:0045333 5 cellular respiration 13 14 1 1 0 1 0 0 69 14 2464 0.68011 1.0 1.0 0.0 0 0 0 0 0 GO:0045337 6 farnesyl diphosphate biosynthetic process 4 4 1 1 1 0 0 0 69 4 2474 0.8959 1.0 1.0 0.0 0 0 0 0 0 GO:0045338 6 farnesyl diphosphate metabolic process 5 5 1 1 1 0 0 0 69 5 2473 0.87159 1.0 1.0 0.0 0 0 0 0 0 GO:0045360 7 regulation of interleukin-1 biosynthetic process 5 6 1 1 1 0 0 0 69 6 2472 0.84794 1.0 1.0 0.0 0 0 0 0 0 GO:0045362 8 positive regulation of interleukin-1 biosynthetic process 5 6 1 1 1 0 0 0 69 6 2472 0.84794 1.0 1.0 0.0 0 0 0 0 0 GO:0045445 5 myoblast differentiation 11 11 1 1 1 0 0 0 69 11 2467 0.73881 1.0 1.0 0.0 0 0 0 0 0 GO:0045472 5 response to ether 8 8 1 1 0 1 0 0 69 8 2470 0.8025 1.0 1.0 0.0 0 0 0 0 0 GO:0045582 9 positive regulation of T cell differentiation 34 35 1 1 0 1 0 0 69 35 2443 0.37991 1.0 1.0 0.0 0 0 0 0 0 GO:0045601 7 regulation of endothelial cell differentiation 18 19 1 1 1 0 0 0 69 19 2459 0.59232 1.0 1.0 0.0 0 0 0 0 0 GO:0045602 8 negative regulation of endothelial cell differentiation 6 6 1 1 1 0 0 0 69 6 2472 0.84794 1.0 1.0 0.0 0 0 0 0 0 GO:0045621 8 positive regulation of lymphocyte differentiation 36 37 1 1 0 1 0 0 69 37 2441 0.35932 1.0 0.62434 0.0 0 0 0 0 0 GO:0045638 7 negative regulation of myeloid cell differentiation 29 31 1 1 0 1 0 0 69 31 2447 0.42464 1.0 1.0 0.0 0 0 0 0 0 GO:0045643 7 regulation of eosinophil differentiation 1 1 1 1 0 1 0 0 69 1 2477 0.97291 1.0 1.0 0.0 0 0 0 0 0 GO:0045645 8 positive regulation of eosinophil differentiation 1 1 1 1 0 1 0 0 69 1 2477 0.97291 1.0 1.0 0.0 0 0 0 0 0 GO:0045649 8 regulation of macrophage differentiation 10 10 1 1 0 1 0 0 69 10 2468 0.75947 1.0 1.0 0.0 0 0 0 0 0 GO:0045651 9 positive regulation of macrophage differentiation 7 7 1 1 0 1 0 0 69 7 2471 0.82491 1.0 1.0 0.0 0 0 0 0 0 GO:0045658 9 regulation of neutrophil differentiation 2 2 1 1 0 1 0 0 69 2 2476 0.94654 1.0 1.0 0.0 0 0 0 0 0 GO:0045659 10 negative regulation of neutrophil differentiation 1 1 1 1 0 1 0 0 69 1 2477 0.97291 1.0 1.0 0.0 0 0 0 0 0 GO:0045661 6 regulation of myoblast differentiation 19 20 1 1 1 0 0 0 69 20 2458 0.57616 1.0 1.0 0.0 0 0 0 0 0 GO:0045663 7 positive regulation of myoblast differentiation 8 8 1 1 1 0 0 0 69 8 2470 0.8025 1.0 1.0 0.0 0 0 0 0 0 GO:0045723 8 positive regulation of fatty acid biosynthetic process 13 14 1 1 1 0 0 0 69 14 2464 0.68011 1.0 1.0 0.0 0 0 0 0 0 GO:0045730 3 respiratory burst 6 6 1 1 0 1 0 0 69 6 2472 0.84794 1.0 1.0 0.0 0 0 0 0 0 GO:0045736 9 negative regulation of cyclin-dependent protein serine/threonine kinase activity 8 8 1 1 1 0 0 0 69 8 2470 0.8025 1.0 1.0 0.0 0 0 0 0 0 GO:0045744 7 negative regulation of G protein-coupled receptor signaling pathway 10 10 1 1 1 0 0 0 69 10 2468 0.75947 1.0 1.0 0.0 0 0 0 0 0 GO:0045764 7 positive regulation of cellular amino acid metabolic process 2 2 1 1 0 1 0 0 69 2 2476 0.94654 1.0 1.0 0.0 0 0 0 0 0 GO:0045769 7 negative regulation of asymmetric cell division 1 1 1 1 1 0 0 0 69 1 2477 0.97291 1.0 1.0 0.0 0 0 0 0 0 GO:0045776 5 negative regulation of blood pressure 16 18 1 1 1 0 0 0 69 18 2460 0.60894 1.0 1.0 0.0 0 0 0 0 0 GO:0045777 5 positive regulation of blood pressure 13 15 3 3 2 1 0 0 69 15 2463 0.66158 1.0 1.0 0.0 0 0 0 0 0 GO:0045785 6 positive regulation of cell adhesion 137 145 3 3 2 1 0 0 69 145 2333 0.016555 1.0 0.031335 0.0 0 0 0 0 0 GO:0045797 8 positive regulation of intestinal cholesterol absorption 1 1 1 1 1 0 0 0 69 1 2477 0.97291 1.0 1.0 0.0 0 0 0 0 0 GO:0045820 7 negative regulation of glycolytic process 7 7 1 1 1 0 0 0 69 7 2471 0.82491 1.0 1.0 0.0 0 0 0 0 0 GO:0045839 8 negative regulation of mitotic nuclear division 15 15 1 1 1 0 0 0 69 15 2463 0.66158 1.0 1.0 0.0 0 0 0 0 0 GO:0045841 9 negative regulation of mitotic metaphase/anaphase transition 10 10 1 1 1 0 0 0 69 10 2468 0.75947 1.0 1.0 0.0 0 0 0 0 0 GO:0045843 7 negative regulation of striated muscle tissue development 21 21 1 1 1 0 0 0 69 21 2457 0.56042 1.0 1.0 0.0 0 0 0 0 0 GO:0045844 7 positive regulation of striated muscle tissue development 30 32 1 1 1 0 0 0 69 32 2446 0.41299 1.0 1.0 0.0 0 0 0 0 0 GO:0045848 5 positive regulation of nitrogen utilization 1 1 1 1 0 1 0 0 69 1 2477 0.97291 1.0 1.0 0.0 0 0 0 0 0 GO:0045906 7 negative regulation of vasoconstriction 8 8 1 1 1 0 0 0 69 8 2470 0.8025 1.0 1.0 0.0 0 0 0 0 0 GO:0045912 6 negative regulation of carbohydrate metabolic process 20 23 1 1 1 0 0 0 69 23 2455 0.53022 1.0 1.0 0.0 0 0 0 0 0 GO:0045923 7 positive regulation of fatty acid metabolic process 25 26 1 1 1 0 0 0 69 26 2452 0.4879 1.0 1.0 0.0 0 0 0 0 0 GO:0045927 5 positive regulation of growth 71 75 1 1 0 1 0 0 69 75 2403 0.12359 1.0 0.26703 0.0 0 0 0 0 0 GO:0045980 7 negative regulation of nucleotide metabolic process 8 9 1 1 1 0 0 0 69 9 2469 0.78069 1.0 1.0 0.0 0 0 0 0 0 GO:0046034 3 ATP metabolic process 31 37 1 1 1 0 0 0 69 37 2441 0.35932 1.0 0.62434 0.0 0 0 0 0 0 GO:0046164 5 alcohol catabolic process 12 13 1 1 1 0 0 0 69 13 2465 0.69915 1.0 1.0 0.0 0 0 0 0 0 GO:0046390 6 ribose phosphate biosynthetic process 34 39 1 1 1 0 0 0 69 39 2439 0.33983 1.0 0.62521 0.0 0 0 0 0 0 GO:0046426 8 negative regulation of receptor signaling pathway via JAK-STAT 8 8 1 1 1 0 0 0 69 8 2470 0.8025 1.0 1.0 0.0 0 0 0 0 0 GO:0046470 6 phosphatidylcholine metabolic process 13 15 1 1 1 0 0 0 69 15 2463 0.66158 1.0 1.0 0.0 0 0 0 0 0 GO:0046474 6 glycerophospholipid biosynthetic process 21 23 1 1 1 0 0 0 69 23 2455 0.53022 1.0 1.0 0.0 0 0 0 0 0 GO:0046488 7 phosphatidylinositol metabolic process 26 28 1 1 1 0 0 0 69 28 2450 0.46155 1.0 1.0 0.0 0 0 0 0 0 GO:0046490 6 isopentenyl diphosphate metabolic process 2 2 1 1 1 0 0 0 69 2 2476 0.94654 1.0 1.0 0.0 0 0 0 0 0 GO:0046579 9 positive regulation of Ras protein signal transduction 15 16 1 1 1 0 0 0 69 16 2462 0.64355 1.0 1.0 0.0 0 0 0 0 0 GO:0046580 9 negative regulation of Ras protein signal transduction 9 9 1 1 1 0 0 0 69 9 2469 0.78069 1.0 1.0 0.0 0 0 0 0 0 GO:0046599 7 regulation of centriole replication 4 5 1 1 1 0 0 0 69 5 2473 0.87159 1.0 1.0 0.0 0 0 0 0 0 GO:0046601 8 positive regulation of centriole replication 2 2 1 1 1 0 0 0 69 2 2476 0.94654 1.0 1.0 0.0 0 0 0 0 0 GO:0046605 7 regulation of centrosome cycle 10 11 1 1 1 0 0 0 69 11 2467 0.73881 1.0 1.0 0.0 0 0 0 0 0 GO:0046607 8 positive regulation of centrosome cycle 2 3 1 1 1 0 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:0046620 5 regulation of organ growth 36 37 1 1 1 0 0 0 69 37 2441 0.35932 1.0 0.62434 0.0 0 0 0 0 0 GO:0046621 6 negative regulation of organ growth 14 14 1 1 1 0 0 0 69 14 2464 0.68011 1.0 1.0 0.0 0 0 0 0 0 GO:0046626 6 regulation of insulin receptor signaling pathway 27 27 1 1 0 1 0 0 69 27 2451 0.47454 1.0 1.0 0.0 0 0 0 0 0 GO:0046628 7 positive regulation of insulin receptor signaling pathway 7 7 1 1 0 1 0 0 69 7 2471 0.82491 1.0 1.0 0.0 0 0 0 0 0 GO:0046661 5 male sex differentiation 4 4 1 1 0 1 0 0 69 4 2474 0.8959 1.0 1.0 0.0 0 0 0 0 0 GO:0046676 8 negative regulation of insulin secretion 10 11 1 1 1 0 0 0 69 11 2467 0.73881 1.0 1.0 0.0 0 0 0 0 0 GO:0046689 6 response to mercury ion 10 11 1 1 0 1 0 0 69 11 2467 0.73881 1.0 1.0 0.0 0 0 0 0 0 GO:0046717 6 acid secretion 18 21 2 2 0 2 0 0 69 21 2457 0.56042 1.0 1.0 0.0 0 0 0 0 0 GO:0046822 7 regulation of nucleocytoplasmic transport 42 46 1 1 1 0 0 0 69 46 2432 0.27948 1.0 0.6354 0.0 0 0 0 0 0 GO:0046824 7 positive regulation of nucleocytoplasmic transport 25 27 1 1 1 0 0 0 69 27 2451 0.47454 1.0 1.0 0.0 0 0 0 0 0 GO:0046834 6 lipid phosphorylation 13 14 1 1 1 0 0 0 69 14 2464 0.68011 1.0 1.0 0.0 0 0 0 0 0 GO:0046854 7 phosphatidylinositol phosphorylation 12 12 1 1 1 0 0 0 69 12 2466 0.71871 1.0 1.0 0.0 0 0 0 0 0 GO:0046885 6 regulation of hormone biosynthetic process 16 17 2 2 2 0 0 0 69 17 2461 0.62601 1.0 1.0 0.0 0 0 0 0 0 GO:0046886 7 positive regulation of hormone biosynthetic process 13 14 2 2 2 0 0 0 69 14 2464 0.68011 1.0 1.0 0.0 0 0 0 0 0 GO:0046888 6 negative regulation of hormone secretion 24 25 2 2 2 0 0 0 69 25 2453 0.50162 1.0 1.0 0.0 0 0 0 0 0 GO:0046907 4 intracellular transport 174 183 1 1 1 0 0 0 69 183 2295 0.0054215 1.0 0.0084924 0.0 0 0 0 0 0 GO:0046942 7 carboxylic acid transport 73 76 6 6 3 3 0 0 69 76 2402 0.12014 1.0 0.26861 0.0 0 0 0 0 0 GO:0046950 4 cellular ketone body metabolic process 3 3 1 1 1 0 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:0046952 5 ketone body catabolic process 2 2 1 1 1 0 0 0 69 2 2476 0.94654 1.0 1.0 0.0 0 0 0 0 0 GO:0048011 7 neurotrophin TRK receptor signaling pathway 6 7 1 1 1 0 0 0 69 7 2471 0.82491 1.0 1.0 0.0 0 0 0 0 0 GO:0048012 8 hepatocyte growth factor receptor signaling pathway 6 6 1 1 1 0 0 0 69 6 2472 0.84794 1.0 1.0 0.0 0 0 0 0 0 GO:0048167 5 regulation of synaptic plasticity 59 62 3 3 2 1 0 0 69 62 2416 0.17839 1.0 0.41345 0.0 0 0 0 0 0 GO:0048168 6 regulation of neuronal synaptic plasticity 24 25 2 2 1 1 0 0 69 25 2453 0.50162 1.0 1.0 0.0 0 0 0 0 0 GO:0048169 7 regulation of long-term neuronal synaptic plasticity 15 16 1 1 1 0 0 0 69 16 2462 0.64355 1.0 1.0 0.0 0 0 0 0 0 GO:0048469 4 cell maturation 37 38 2 2 2 0 0 0 69 38 2440 0.34944 1.0 0.62464 0.0 0 0 0 0 0 GO:0048477 5 oogenesis 2 2 1 1 1 0 0 0 69 2 2476 0.94654 1.0 1.0 0.0 0 0 0 0 0 GO:0048525 5 negative regulation of viral process 30 32 1 1 1 0 0 0 69 32 2446 0.41299 1.0 1.0 0.0 0 0 0 0 0 GO:0048534 5 hematopoietic or lymphoid organ development 55 60 2 2 2 0 0 0 69 60 2418 0.18871 1.0 0.40931 0.0 0 0 0 0 0 GO:0048536 6 spleen development 11 12 1 1 1 0 0 0 69 12 2466 0.71871 1.0 1.0 0.0 0 0 0 0 0 GO:0048635 6 negative regulation of muscle organ development 22 22 1 1 1 0 0 0 69 22 2456 0.54512 1.0 1.0 0.0 0 0 0 0 0 GO:0048636 6 positive regulation of muscle organ development 30 32 1 1 1 0 0 0 69 32 2446 0.41299 1.0 1.0 0.0 0 0 0 0 0 GO:0048638 5 regulation of developmental growth 94 100 4 4 4 0 0 0 69 100 2378 0.060687 1.0 0.11195 0.0 0 0 0 0 0 GO:0048640 6 negative regulation of developmental growth 30 32 4 4 4 0 0 0 69 32 2446 0.41299 1.0 1.0 0.0 0 0 0 0 0 GO:0048643 8 positive regulation of skeletal muscle tissue development 10 10 1 1 1 0 0 0 69 10 2468 0.75947 1.0 1.0 0.0 0 0 0 0 0 GO:0048661 7 positive regulation of smooth muscle cell proliferation 52 55 3 3 2 1 0 0 69 55 2423 0.21718 1.0 0.40255 0.0 0 0 0 0 0 GO:0048709 6 oligodendrocyte differentiation 10 11 1 1 1 0 0 0 69 11 2467 0.73881 1.0 1.0 0.0 0 0 0 0 0 GO:0050663 6 cytokine secretion 13 15 1 1 0 1 0 0 69 15 2463 0.66158 1.0 1.0 0.0 0 0 0 0 0 GO:0050670 7 regulation of lymphocyte proliferation 73 78 2 2 2 0 0 0 69 78 2400 0.11352 1.0 0.27227 0.0 0 0 0 0 0 GO:0050671 8 positive regulation of lymphocyte proliferation 47 51 2 2 2 0 0 0 69 51 2427 0.24297 1.0 0.40139 0.0 0 0 0 0 0 GO:0050709 7 negative regulation of protein secretion 32 34 3 3 2 1 0 0 69 34 2444 0.39064 1.0 1.0 0.0 0 0 0 0 0 GO:0050710 6 negative regulation of cytokine secretion 13 14 2 2 1 1 0 0 69 14 2464 0.68011 1.0 1.0 0.0 0 0 0 0 0 GO:0050711 7 negative regulation of interleukin-1 secretion 3 3 1 1 1 0 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:0050713 8 negative regulation of interleukin-1 beta secretion 2 2 1 1 1 0 0 0 69 2 2476 0.94654 1.0 1.0 0.0 0 0 0 0 0 GO:0050722 8 regulation of interleukin-1 beta biosynthetic process 5 6 1 1 1 0 0 0 69 6 2472 0.84794 1.0 1.0 0.0 0 0 0 0 0 GO:0050725 9 positive regulation of interleukin-1 beta biosynthetic process 5 6 1 1 1 0 0 0 69 6 2472 0.84794 1.0 1.0 0.0 0 0 0 0 0 GO:0050764 6 regulation of phagocytosis 46 51 2 2 1 1 0 0 69 51 2427 0.24297 1.0 0.40139 0.0 0 0 0 0 0 GO:0050766 6 positive regulation of phagocytosis 30 35 2 2 1 1 0 0 69 35 2443 0.37991 1.0 1.0 0.0 0 0 0 0 0 GO:0050804 6 modulation of chemical synaptic transmission 117 127 3 3 2 1 0 0 69 127 2351 0.027917 1.0 0.047614 0.0 0 0 0 0 0 GO:0050806 6 positive regulation of synaptic transmission 48 51 1 1 1 0 0 0 69 51 2427 0.24297 1.0 0.40139 0.0 0 0 0 0 0 GO:0050807 6 regulation of synapse organization 52 60 1 1 1 0 0 0 69 60 2418 0.18871 1.0 0.40931 0.0 0 0 0 0 0 GO:0050821 5 protein stabilization 40 48 2 2 2 0 0 0 69 48 2430 0.26427 1.0 0.63996 0.0 0 0 0 0 0 GO:0050848 7 regulation of calcium-mediated signaling 33 35 1 1 0 1 0 0 69 35 2443 0.37991 1.0 1.0 0.0 0 0 0 0 0 GO:0050849 8 negative regulation of calcium-mediated signaling 9 10 1 1 0 1 0 0 69 10 2468 0.75947 1.0 1.0 0.0 0 0 0 0 0 GO:0050850 8 positive regulation of calcium-mediated signaling 20 21 1 1 0 1 0 0 69 21 2457 0.56042 1.0 1.0 0.0 0 0 0 0 0 GO:0050864 7 regulation of B cell activation 41 43 1 1 1 0 0 0 69 43 2435 0.30393 1.0 0.62982 0.0 0 0 0 0 0 GO:0050867 6 positive regulation of cell activation 103 110 3 3 2 1 0 0 69 110 2368 0.045566 1.0 0.072917 0.0 0 0 0 0 0 GO:0050870 8 positive regulation of T cell activation 64 67 2 2 1 1 0 0 69 67 2411 0.15494 1.0 0.26079 0.0 0 0 0 0 0 GO:0050871 8 positive regulation of B cell activation 27 29 1 1 1 0 0 0 69 29 2449 0.44891 1.0 1.0 0.0 0 0 0 0 0 GO:0050886 4 endocrine process 7 10 2 2 1 1 0 0 69 10 2468 0.75947 1.0 1.0 0.0 0 0 0 0 0 GO:0050890 5 cognition 83 87 2 2 2 0 0 0 69 87 2391 0.087925 1.0 0.17219 0.0 0 0 0 0 0 GO:0050891 4 multicellular organismal water homeostasis 11 11 1 1 1 0 0 0 69 11 2467 0.73881 1.0 1.0 0.0 0 0 0 0 0 GO:0050892 5 intestinal absorption 9 9 1 1 1 0 0 0 69 9 2469 0.78069 1.0 1.0 0.0 0 0 0 0 0 GO:0050901 7 leukocyte tethering or rolling 7 8 1 1 1 0 0 0 69 8 2470 0.8025 1.0 1.0 0.0 0 0 0 0 0 GO:0050919 5 negative chemotaxis 5 5 1 1 1 0 0 0 69 5 2473 0.87159 1.0 1.0 0.0 0 0 0 0 0 GO:0050996 7 positive regulation of lipid catabolic process 13 15 1 1 1 0 0 0 69 15 2463 0.66158 1.0 1.0 0.0 0 0 0 0 0 GO:0051006 8 positive regulation of lipoprotein lipase activity 5 5 1 1 1 0 0 0 69 5 2473 0.87159 1.0 1.0 0.0 0 0 0 0 0 GO:0051048 6 negative regulation of secretion 62 66 4 4 3 1 0 0 69 66 2412 0.15937 1.0 0.26089 0.0 0 0 0 0 0 GO:0051053 7 negative regulation of DNA metabolic process 19 19 1 1 1 0 0 0 69 19 2459 0.59232 1.0 1.0 0.0 0 0 0 0 0 GO:0051057 8 positive regulation of small GTPase mediated signal transduction 17 18 1 1 1 0 0 0 69 18 2460 0.60894 1.0 1.0 0.0 0 0 0 0 0 GO:0051058 8 negative regulation of small GTPase mediated signal transduction 9 9 1 1 1 0 0 0 69 9 2469 0.78069 1.0 1.0 0.0 0 0 0 0 0 GO:0051084 5 'de novo' posttranslational protein folding 12 16 1 1 1 0 0 0 69 16 2462 0.64355 1.0 1.0 0.0 0 0 0 0 0 GO:0051085 5 chaperone cofactor-dependent protein refolding 9 13 1 1 1 0 0 0 69 13 2465 0.69915 1.0 1.0 0.0 0 0 0 0 0 GO:0051092 9 positive regulation of NF-kappaB transcription factor activity 44 48 1 1 1 0 0 0 69 48 2430 0.26427 1.0 0.63996 0.0 0 0 0 0 0 GO:0051098 4 regulation of binding 106 113 3 3 2 1 0 0 69 113 2365 0.041803 1.0 0.072938 0.0 0 0 0 0 0 GO:0051099 5 positive regulation of binding 56 61 2 2 1 1 0 0 69 61 2417 0.18348 1.0 0.41128 0.0 0 0 0 0 0 GO:0051100 5 negative regulation of binding 52 53 2 2 2 0 0 0 69 53 2425 0.22972 1.0 0.40146 0.0 0 0 0 0 0 GO:0051131 8 chaperone-mediated protein complex assembly 7 8 1 1 1 0 0 0 69 8 2470 0.8025 1.0 1.0 0.0 0 0 0 0 0 GO:0051147 6 regulation of muscle cell differentiation 57 60 2 2 2 0 0 0 69 60 2418 0.18871 1.0 0.40931 0.0 0 0 0 0 0 GO:0051148 7 negative regulation of muscle cell differentiation 24 24 1 1 1 0 0 0 69 24 2454 0.51572 1.0 1.0 0.0 0 0 0 0 0 GO:0051149 7 positive regulation of muscle cell differentiation 27 30 1 1 1 0 0 0 69 30 2448 0.43661 1.0 1.0 0.0 0 0 0 0 0 GO:0051153 7 regulation of striated muscle cell differentiation 45 47 2 2 2 0 0 0 69 47 2431 0.27177 1.0 0.6376 0.0 0 0 0 0 0 GO:0051154 8 negative regulation of striated muscle cell differentiation 18 18 1 1 1 0 0 0 69 18 2460 0.60894 1.0 1.0 0.0 0 0 0 0 0 GO:0051155 8 positive regulation of striated muscle cell differentiation 23 25 1 1 1 0 0 0 69 25 2453 0.50162 1.0 1.0 0.0 0 0 0 0 0 GO:0051156 5 glucose 6-phosphate metabolic process 5 5 1 1 1 0 0 0 69 5 2473 0.87159 1.0 1.0 0.0 0 0 0 0 0 GO:0051169 5 nuclear transport 37 41 1 1 1 0 0 0 69 41 2437 0.32139 1.0 0.62707 0.0 0 0 0 0 0 GO:0051170 7 import into nucleus 23 24 1 1 1 0 0 0 69 24 2454 0.51572 1.0 1.0 0.0 0 0 0 0 0 GO:0051180 5 vitamin transport 12 14 1 1 1 0 0 0 69 14 2464 0.68011 1.0 1.0 0.0 0 0 0 0 0 GO:0051225 5 spindle assembly 18 18 2 2 2 0 0 0 69 18 2460 0.60894 1.0 1.0 0.0 0 0 0 0 0 GO:0051251 7 positive regulation of lymphocyte activation 82 87 3 3 2 1 0 0 69 87 2391 0.087925 1.0 0.17219 0.0 0 0 0 0 0 GO:0051255 4 spindle midzone assembly 3 4 1 1 1 0 0 0 69 4 2474 0.8959 1.0 1.0 0.0 0 0 0 0 0 GO:0051256 5 mitotic spindle midzone assembly 3 4 1 1 1 0 0 0 69 4 2474 0.8959 1.0 1.0 0.0 0 0 0 0 0 GO:0051260 8 protein homooligomerization 31 35 2 2 2 0 0 0 69 35 2443 0.37991 1.0 1.0 0.0 0 0 0 0 0 GO:0051261 8 protein depolymerization 9 11 2 2 2 0 0 0 69 11 2467 0.73881 1.0 1.0 0.0 0 0 0 0 0 GO:0051279 6 regulation of release of sequestered calcium ion into cytosol 23 24 2 2 0 2 0 0 69 24 2454 0.51572 1.0 1.0 0.0 0 0 0 0 0 GO:0051280 6 negative regulation of release of sequestered calcium ion into cytosol 5 5 1 1 0 1 0 0 69 5 2473 0.87159 1.0 1.0 0.0 0 0 0 0 0 GO:0051281 11 positive regulation of release of sequestered calcium ion into cytosol 12 13 1 1 0 1 0 0 69 13 2465 0.69915 1.0 1.0 0.0 0 0 0 0 0 GO:0051282 4 regulation of sequestering of calcium ion 38 39 2 2 0 2 0 0 69 39 2439 0.33983 1.0 0.62521 0.0 0 0 0 0 0 GO:0051284 5 positive regulation of sequestering of calcium ion 5 5 1 1 0 1 0 0 69 5 2473 0.87159 1.0 1.0 0.0 0 0 0 0 0 GO:0051293 6 establishment of spindle localization 10 10 1 1 1 0 0 0 69 10 2468 0.75947 1.0 1.0 0.0 0 0 0 0 0 GO:0051294 7 establishment of spindle orientation 8 8 1 1 1 0 0 0 69 8 2470 0.8025 1.0 1.0 0.0 0 0 0 0 0 GO:0051315 5 attachment of mitotic spindle microtubules to kinetochore 3 3 1 1 1 0 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:0051321 3 meiotic cell cycle 9 10 1 1 1 0 0 0 69 10 2468 0.75947 1.0 1.0 0.0 0 0 0 0 0 GO:0051383 7 kinetochore organization 9 9 1 1 1 0 0 0 69 9 2469 0.78069 1.0 1.0 0.0 0 0 0 0 0 GO:0051385 7 response to mineralocorticoid 32 37 2 2 1 1 0 0 69 37 2441 0.35932 1.0 0.62434 0.0 0 0 0 0 0 GO:0051403 9 stress-activated MAPK cascade 16 17 1 1 0 1 0 0 69 17 2461 0.62601 1.0 1.0 0.0 0 0 0 0 0 GO:0051410 3 detoxification of nitrogen compound 2 4 1 1 0 1 0 0 69 4 2474 0.8959 1.0 1.0 0.0 0 0 0 0 0 GO:0051412 6 response to corticosterone 23 27 1 1 1 0 0 0 69 27 2451 0.47454 1.0 1.0 0.0 0 0 0 0 0 GO:0051438 8 regulation of ubiquitin-protein transferase activity 15 16 3 3 2 1 0 0 69 16 2462 0.64355 1.0 1.0 0.0 0 0 0 0 0 GO:0051443 9 positive regulation of ubiquitin-protein transferase activity 9 9 2 2 1 1 0 0 69 9 2469 0.78069 1.0 1.0 0.0 0 0 0 0 0 GO:0051444 9 negative regulation of ubiquitin-protein transferase activity 5 6 1 1 1 0 0 0 69 6 2472 0.84794 1.0 1.0 0.0 0 0 0 0 0 GO:0051445 5 regulation of meiotic cell cycle 17 19 2 2 2 0 0 0 69 19 2459 0.59232 1.0 1.0 0.0 0 0 0 0 0 GO:0051446 6 positive regulation of meiotic cell cycle 11 11 1 1 1 0 0 0 69 11 2467 0.73881 1.0 1.0 0.0 0 0 0 0 0 GO:0051492 7 regulation of stress fiber assembly 24 27 3 3 2 0 0 0 69 27 2451 0.47454 1.0 1.0 0.0 0 0 0 0 0 GO:0051494 8 negative regulation of cytoskeleton organization 28 32 2 2 2 0 0 0 69 32 2446 0.41299 1.0 1.0 0.0 0 0 0 0 0 GO:0051495 8 positive regulation of cytoskeleton organization 51 55 4 4 3 0 0 0 69 55 2423 0.21718 1.0 0.40255 0.0 0 0 0 0 0 GO:0051496 8 positive regulation of stress fiber assembly 18 21 2 2 1 0 0 0 69 21 2457 0.56042 1.0 1.0 0.0 0 0 0 0 0 GO:0051497 8 negative regulation of stress fiber assembly 4 4 1 1 1 0 0 0 69 4 2474 0.8959 1.0 1.0 0.0 0 0 0 0 0 GO:0051503 9 adenine nucleotide transport 5 5 1 0 0 1 0 0 69 5 2473 0.87159 1.0 1.0 0.0 0 0 0 0 0 GO:0051592 6 response to calcium ion 51 56 1 1 1 0 0 0 69 56 2422 0.21117 1.0 0.40345 0.0 0 0 0 0 0 GO:0051597 5 response to methylmercury 6 8 1 1 1 0 0 0 69 8 2470 0.8025 1.0 1.0 0.0 0 0 0 0 0 GO:0051602 4 response to electrical stimulus 25 25 2 2 1 0 0 0 69 25 2453 0.50162 1.0 1.0 0.0 0 0 0 0 0 GO:0051603 6 proteolysis involved in cellular protein catabolic process 79 84 1 1 1 0 0 0 69 84 2394 0.095753 1.0 0.17062 0.0 0 0 0 0 0 GO:0051607 5 defense response to virus 45 46 2 2 2 0 0 0 69 46 2432 0.27948 1.0 0.6354 0.0 0 0 0 0 0 GO:0051642 4 centrosome localization 5 5 2 2 2 0 0 0 69 5 2473 0.87159 1.0 1.0 0.0 0 0 0 0 0 GO:0051653 4 spindle localization 12 12 2 2 2 0 0 0 69 12 2466 0.71871 1.0 1.0 0.0 0 0 0 0 0 GO:0051657 5 maintenance of organelle location 4 4 1 1 1 0 0 0 69 4 2474 0.8959 1.0 1.0 0.0 0 0 0 0 0 GO:0051660 5 establishment of centrosome localization 2 2 1 1 1 0 0 0 69 2 2476 0.94654 1.0 1.0 0.0 0 0 0 0 0 GO:0051661 6 maintenance of centrosome location 2 2 1 1 1 0 0 0 69 2 2476 0.94654 1.0 1.0 0.0 0 0 0 0 0 GO:0051764 7 actin crosslink formation 4 4 1 1 1 0 0 0 69 4 2474 0.8959 1.0 1.0 0.0 0 0 0 0 0 GO:0051782 6 negative regulation of cell division 7 7 1 1 1 0 0 0 69 7 2471 0.82491 1.0 1.0 0.0 0 0 0 0 0 GO:0051783 7 regulation of nuclear division 47 50 4 4 4 0 0 0 69 50 2428 0.24988 1.0 0.64509 0.0 0 0 0 0 0 GO:0051784 8 negative regulation of nuclear division 15 15 1 1 1 0 0 0 69 15 2463 0.66158 1.0 1.0 0.0 0 0 0 0 0 GO:0051791 7 medium-chain fatty acid metabolic process 7 8 1 1 1 0 0 0 69 8 2470 0.8025 1.0 1.0 0.0 0 0 0 0 0 GO:0051924 8 regulation of calcium ion transport 78 85 3 3 1 2 0 0 69 85 2393 0.09307 1.0 0.171 0.0 0 0 0 0 0 GO:0051926 7 negative regulation of calcium ion transport 19 21 1 1 0 1 0 0 69 21 2457 0.56042 1.0 1.0 0.0 0 0 0 0 0 GO:0051928 7 positive regulation of calcium ion transport 41 45 2 2 1 1 0 0 69 45 2433 0.28741 1.0 0.63336 0.0 0 0 0 0 0 GO:0051983 5 regulation of chromosome segregation 25 27 3 3 3 0 0 0 69 27 2451 0.47454 1.0 1.0 0.0 0 0 0 0 0 GO:0051985 6 negative regulation of chromosome segregation 12 12 1 1 1 0 0 0 69 12 2466 0.71871 1.0 1.0 0.0 0 0 0 0 0 GO:0051988 6 regulation of attachment of spindle microtubules to kinetochore 6 7 1 1 1 0 0 0 69 7 2471 0.82491 1.0 1.0 0.0 0 0 0 0 0 GO:0055021 7 regulation of cardiac muscle tissue growth 28 29 1 1 1 0 0 0 69 29 2449 0.44891 1.0 1.0 0.0 0 0 0 0 0 GO:0055022 8 negative regulation of cardiac muscle tissue growth 11 11 1 1 1 0 0 0 69 11 2467 0.73881 1.0 1.0 0.0 0 0 0 0 0 GO:0055024 7 regulation of cardiac muscle tissue development 35 37 1 1 1 0 0 0 69 37 2441 0.35932 1.0 0.62434 0.0 0 0 0 0 0 GO:0055026 8 negative regulation of cardiac muscle tissue development 14 14 1 1 1 0 0 0 69 14 2464 0.68011 1.0 1.0 0.0 0 0 0 0 0 GO:0055057 5 neuroblast division 4 4 1 1 1 0 0 0 69 4 2474 0.8959 1.0 1.0 0.0 0 0 0 0 0 GO:0055081 7 anion homeostasis 21 21 2 2 1 1 0 0 69 21 2457 0.56042 1.0 1.0 0.0 0 0 0 0 0 GO:0055089 7 fatty acid homeostasis 7 7 1 1 0 1 0 0 69 7 2471 0.82491 1.0 1.0 0.0 0 0 0 0 0 GO:0055091 7 phospholipid homeostasis 4 4 1 1 1 0 0 0 69 4 2474 0.8959 1.0 1.0 0.0 0 0 0 0 0 GO:0055094 4 response to lipoprotein particle 21 21 1 1 1 0 0 0 69 21 2457 0.56042 1.0 1.0 0.0 0 0 0 0 0 GO:0060086 6 circadian temperature homeostasis 1 2 1 1 1 0 0 0 69 2 2476 0.94654 1.0 1.0 0.0 0 0 0 0 0 GO:0060142 6 regulation of syncytium formation by plasma membrane fusion 13 13 1 1 1 0 0 0 69 13 2465 0.69915 1.0 1.0 0.0 0 0 0 0 0 GO:0060143 6 positive regulation of syncytium formation by plasma membrane fusion 9 9 1 1 1 0 0 0 69 9 2469 0.78069 1.0 1.0 0.0 0 0 0 0 0 GO:0060236 7 regulation of mitotic spindle organization 10 10 1 1 1 0 0 0 69 10 2468 0.75947 1.0 1.0 0.0 0 0 0 0 0 GO:0060271 7 cilium assembly 15 16 2 1 1 0 0 0 69 16 2462 0.64355 1.0 1.0 0.0 0 0 0 0 0 GO:0060281 6 regulation of oocyte development 12 13 1 1 1 0 0 0 69 13 2465 0.69915 1.0 1.0 0.0 0 0 0 0 0 GO:0060282 7 positive regulation of oocyte development 7 7 1 1 1 0 0 0 69 7 2471 0.82491 1.0 1.0 0.0 0 0 0 0 0 GO:0060291 5 long-term synaptic potentiation 17 17 1 1 1 0 0 0 69 17 2461 0.62601 1.0 1.0 0.0 0 0 0 0 0 GO:0060314 6 regulation of ryanodine-sensitive calcium-release channel activity 5 5 1 1 0 1 0 0 69 5 2473 0.87159 1.0 1.0 0.0 0 0 0 0 0 GO:0060315 7 negative regulation of ryanodine-sensitive calcium-release channel activity 3 3 1 1 0 1 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:0060316 12 positive regulation of ryanodine-sensitive calcium-release channel activity 3 3 1 1 0 1 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:0060353 5 regulation of cell adhesion molecule production 7 7 1 1 1 0 0 0 69 7 2471 0.82491 1.0 1.0 0.0 0 0 0 0 0 GO:0060354 6 negative regulation of cell adhesion molecule production 3 3 1 1 1 0 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:0060384 3 innervation 5 5 1 1 1 0 0 0 69 5 2473 0.87159 1.0 1.0 0.0 0 0 0 0 0 GO:0060396 8 growth hormone receptor signaling pathway 8 8 1 1 1 0 0 0 69 8 2470 0.8025 1.0 1.0 0.0 0 0 0 0 0 GO:0060398 6 regulation of growth hormone receptor signaling pathway 2 2 1 1 1 0 0 0 69 2 2476 0.94654 1.0 1.0 0.0 0 0 0 0 0 GO:0060400 7 negative regulation of growth hormone receptor signaling pathway 1 1 1 1 1 0 0 0 69 1 2477 0.97291 1.0 1.0 0.0 0 0 0 0 0 GO:0060420 6 regulation of heart growth 30 31 1 1 1 0 0 0 69 31 2447 0.42464 1.0 1.0 0.0 0 0 0 0 0 GO:0060456 6 positive regulation of digestive system process 3 4 1 1 1 0 0 0 69 4 2474 0.8959 1.0 1.0 0.0 0 0 0 0 0 GO:0060574 7 intestinal epithelial cell maturation 3 4 1 1 1 0 0 0 69 4 2474 0.8959 1.0 1.0 0.0 0 0 0 0 0 GO:0060612 6 adipose tissue development 13 14 1 1 0 1 0 0 69 14 2464 0.68011 1.0 1.0 0.0 0 0 0 0 0 GO:0060669 4 embryonic placenta morphogenesis 1 1 1 1 1 0 0 0 69 1 2477 0.97291 1.0 1.0 0.0 0 0 0 0 0 GO:0060699 8 regulation of endoribonuclease activity 2 3 1 1 1 0 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:0060700 7 regulation of ribonuclease activity 4 5 1 1 1 0 0 0 69 5 2473 0.87159 1.0 1.0 0.0 0 0 0 0 0 GO:0060706 4 cell differentiation involved in embryonic placenta development 11 11 1 1 1 0 0 0 69 11 2467 0.73881 1.0 1.0 0.0 0 0 0 0 0 GO:0060707 5 trophoblast giant cell differentiation 6 6 1 1 1 0 0 0 69 6 2472 0.84794 1.0 1.0 0.0 0 0 0 0 0 GO:0060710 4 chorio-allantoic fusion 4 4 1 1 1 0 0 0 69 4 2474 0.8959 1.0 1.0 0.0 0 0 0 0 0 GO:0060761 6 negative regulation of response to cytokine stimulus 14 14 2 2 1 1 0 0 69 14 2464 0.68011 1.0 1.0 0.0 0 0 0 0 0 GO:0060828 7 regulation of canonical Wnt signaling pathway 45 47 2 2 2 0 0 0 69 47 2431 0.27177 1.0 0.6376 0.0 0 0 0 0 0 GO:0060945 6 cardiac neuron differentiation 1 1 1 1 1 0 0 0 69 1 2477 0.97291 1.0 1.0 0.0 0 0 0 0 0 GO:0060992 5 response to fungicide 17 19 2 2 1 1 0 0 69 19 2459 0.59232 1.0 1.0 0.0 0 0 0 0 0 GO:0061050 6 regulation of cell growth involved in cardiac muscle cell development 14 14 1 1 1 0 0 0 69 14 2464 0.68011 1.0 1.0 0.0 0 0 0 0 0 GO:0061052 7 negative regulation of cell growth involved in cardiac muscle cell development 5 5 1 1 1 0 0 0 69 5 2473 0.87159 1.0 1.0 0.0 0 0 0 0 0 GO:0061077 4 chaperone-mediated protein folding 17 21 1 1 1 0 0 0 69 21 2457 0.56042 1.0 1.0 0.0 0 0 0 0 0 GO:0061117 7 negative regulation of heart growth 11 11 1 1 1 0 0 0 69 11 2467 0.73881 1.0 1.0 0.0 0 0 0 0 0 GO:0061178 6 regulation of insulin secretion involved in cellular response to glucose stimulus 18 19 2 2 1 1 0 0 69 19 2459 0.59232 1.0 1.0 0.0 0 0 0 0 0 GO:0061179 7 negative regulation of insulin secretion involved in cellular response to glucose stimulus 2 2 1 1 1 0 0 0 69 2 2476 0.94654 1.0 1.0 0.0 0 0 0 0 0 GO:0061365 8 positive regulation of triglyceride lipase activity 5 5 1 1 1 0 0 0 69 5 2473 0.87159 1.0 1.0 0.0 0 0 0 0 0 GO:0061418 9 regulation of transcription from RNA polymerase II promoter in response to hypoxia 6 7 1 1 1 0 0 0 69 7 2471 0.82491 1.0 1.0 0.0 0 0 0 0 0 GO:0061436 6 establishment of skin barrier 6 6 1 1 1 0 0 0 69 6 2472 0.84794 1.0 1.0 0.0 0 0 0 0 0 GO:0061448 5 connective tissue development 16 17 1 1 0 1 0 0 69 17 2461 0.62601 1.0 1.0 0.0 0 0 0 0 0 GO:0061458 5 reproductive system development 6 6 1 1 0 1 0 0 69 6 2472 0.84794 1.0 1.0 0.0 0 0 0 0 0 GO:0061476 5 response to anticoagulant 2 2 1 1 1 0 0 0 69 2 2476 0.94654 1.0 1.0 0.0 0 0 0 0 0 GO:0061640 5 cytoskeleton-dependent cytokinesis 16 19 4 4 4 0 0 0 69 19 2459 0.59232 1.0 1.0 0.0 0 0 0 0 0 GO:0061756 6 leukocyte adhesion to vascular endothelial cell 7 8 1 1 1 0 0 0 69 8 2470 0.8025 1.0 1.0 0.0 0 0 0 0 0 GO:0061771 4 response to caloric restriction 4 4 1 1 1 0 0 0 69 4 2474 0.8959 1.0 1.0 0.0 0 0 0 0 0 GO:0061842 3 microtubule organizing center localization 5 5 2 2 2 0 0 0 69 5 2473 0.87159 1.0 1.0 0.0 0 0 0 0 0 GO:0062208 7 positive regulation of pattern recognition receptor signaling pathway 10 10 2 2 1 1 0 0 69 10 2468 0.75947 1.0 1.0 0.0 0 0 0 0 0 GO:0065005 7 protein-lipid complex assembly 7 7 2 2 2 0 0 0 69 7 2471 0.82491 1.0 1.0 0.0 0 0 0 0 0 GO:0070059 7 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress 15 15 1 1 0 1 0 0 69 15 2463 0.66158 1.0 1.0 0.0 0 0 0 0 0 GO:0070206 8 protein trimerization 6 8 1 1 1 0 0 0 69 8 2470 0.8025 1.0 1.0 0.0 0 0 0 0 0 GO:0070207 9 protein homotrimerization 4 5 1 1 1 0 0 0 69 5 2473 0.87159 1.0 1.0 0.0 0 0 0 0 0 GO:0070255 5 regulation of mucus secretion 3 3 1 1 0 1 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:0070257 6 positive regulation of mucus secretion 3 3 1 1 0 1 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:0070293 5 renal absorption 4 4 1 1 1 0 0 0 69 4 2474 0.8959 1.0 1.0 0.0 0 0 0 0 0 GO:0070304 7 positive regulation of stress-activated protein kinase signaling cascade 41 45 1 1 1 0 0 0 69 45 2433 0.28741 1.0 0.63336 0.0 0 0 0 0 0 GO:0070370 6 cellular heat acclimation 2 2 1 1 1 0 0 0 69 2 2476 0.94654 1.0 1.0 0.0 0 0 0 0 0 GO:0070371 9 ERK1 and ERK2 cascade 13 14 1 1 1 0 0 0 69 14 2464 0.68011 1.0 1.0 0.0 0 0 0 0 0 GO:0070424 7 regulation of nucleotide-binding oligomerization domain containing signaling pathway 4 4 1 1 1 0 0 0 69 4 2474 0.8959 1.0 1.0 0.0 0 0 0 0 0 GO:0070426 8 positive regulation of nucleotide-binding oligomerization domain containing signaling pathway 3 3 1 1 1 0 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:0070432 8 regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway 4 4 1 1 1 0 0 0 69 4 2474 0.8959 1.0 1.0 0.0 0 0 0 0 0 GO:0070434 9 positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway 3 3 1 1 1 0 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:0070458 4 cellular detoxification of nitrogen compound 2 4 1 1 0 1 0 0 69 4 2474 0.8959 1.0 1.0 0.0 0 0 0 0 0 GO:0070494 7 regulation of thrombin-activated receptor signaling pathway 3 3 1 1 1 0 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:0070495 8 negative regulation of thrombin-activated receptor signaling pathway 3 3 1 1 1 0 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:0070508 9 cholesterol import 4 4 1 1 1 0 0 0 69 4 2474 0.8959 1.0 1.0 0.0 0 0 0 0 0 GO:0070587 7 regulation of cell-cell adhesion involved in gastrulation 4 4 1 1 1 0 0 0 69 4 2474 0.8959 1.0 1.0 0.0 0 0 0 0 0 GO:0070647 7 protein modification by small protein conjugation or removal 93 94 2 2 2 0 0 0 69 94 2384 0.072031 1.0 0.18056 0.0 0 0 0 0 0 GO:0070665 7 positive regulation of leukocyte proliferation 54 58 2 2 2 0 0 0 69 58 2420 0.19963 1.0 0.40595 0.0 0 0 0 0 0 GO:0070830 9 bicellular tight junction assembly 9 9 1 1 1 0 0 0 69 9 2469 0.78069 1.0 1.0 0.0 0 0 0 0 0 GO:0070857 7 regulation of bile acid biosynthetic process 4 5 2 2 2 0 0 0 69 5 2473 0.87159 1.0 1.0 0.0 0 0 0 0 0 GO:0070989 4 oxidative demethylation 3 4 1 1 0 1 0 0 69 4 2474 0.8959 1.0 1.0 0.0 0 0 0 0 0 GO:0071071 7 regulation of phospholipid biosynthetic process 7 7 1 1 0 1 0 0 69 7 2471 0.82491 1.0 1.0 0.0 0 0 0 0 0 GO:0071073 8 positive regulation of phospholipid biosynthetic process 4 4 1 1 0 1 0 0 69 4 2474 0.8959 1.0 1.0 0.0 0 0 0 0 0 GO:0071156 7 regulation of cell cycle arrest 20 21 1 1 1 0 0 0 69 21 2457 0.56042 1.0 1.0 0.0 0 0 0 0 0 GO:0071158 8 positive regulation of cell cycle arrest 13 13 1 1 1 0 0 0 69 13 2465 0.69915 1.0 1.0 0.0 0 0 0 0 0 GO:0071173 8 spindle assembly checkpoint 9 9 1 1 1 0 0 0 69 9 2469 0.78069 1.0 1.0 0.0 0 0 0 0 0 GO:0071174 8 mitotic spindle checkpoint 9 9 1 1 1 0 0 0 69 9 2469 0.78069 1.0 1.0 0.0 0 0 0 0 0 GO:0071277 7 cellular response to calcium ion 24 25 1 1 1 0 0 0 69 25 2453 0.50162 1.0 1.0 0.0 0 0 0 0 0 GO:0071312 6 cellular response to alkaloid 21 22 3 3 2 1 0 0 69 22 2456 0.54512 1.0 1.0 0.0 0 0 0 0 0 GO:0071313 6 cellular response to caffeine 5 5 1 1 0 1 0 0 69 5 2473 0.87159 1.0 1.0 0.0 0 0 0 0 0 GO:0071314 6 cellular response to cocaine 1 1 1 1 1 0 0 0 69 1 2477 0.97291 1.0 1.0 0.0 0 0 0 0 0 GO:0071317 7 cellular response to isoquinoline alkaloid 4 4 1 1 1 0 0 0 69 4 2474 0.8959 1.0 1.0 0.0 0 0 0 0 0 GO:0071394 6 cellular response to testosterone stimulus 7 8 1 1 0 1 0 0 69 8 2470 0.8025 1.0 1.0 0.0 0 0 0 0 0 GO:0071402 4 cellular response to lipoprotein particle stimulus 23 23 1 1 1 0 0 0 69 23 2455 0.53022 1.0 1.0 0.0 0 0 0 0 0 GO:0071404 5 cellular response to low-density lipoprotein particle stimulus 17 17 1 1 1 0 0 0 69 17 2461 0.62601 1.0 1.0 0.0 0 0 0 0 0 GO:0071415 6 cellular response to purine-containing compound 6 6 1 1 0 1 0 0 69 6 2472 0.84794 1.0 1.0 0.0 0 0 0 0 0 GO:0071453 5 cellular response to oxygen levels 66 69 2 2 2 0 0 0 69 69 2409 0.14644 1.0 0.26121 0.0 0 0 0 0 0 GO:0071455 5 cellular response to hyperoxia 5 5 1 1 1 0 0 0 69 5 2473 0.87159 1.0 1.0 0.0 0 0 0 0 0 GO:0071456 5 cellular response to hypoxia 57 60 2 2 2 0 0 0 69 60 2418 0.18871 1.0 0.40931 0.0 0 0 0 0 0 GO:0071478 5 cellular response to radiation 59 61 5 5 3 2 0 0 69 61 2417 0.18348 1.0 0.41128 0.0 0 0 0 0 0 GO:0071479 6 cellular response to ionizing radiation 24 24 4 4 3 1 0 0 69 24 2454 0.51572 1.0 1.0 0.0 0 0 0 0 0 GO:0071480 7 cellular response to gamma radiation 15 15 3 3 2 1 0 0 69 15 2463 0.66158 1.0 1.0 0.0 0 0 0 0 0 GO:0071482 6 cellular response to light stimulus 37 39 2 2 1 1 0 0 69 39 2439 0.33983 1.0 0.62521 0.0 0 0 0 0 0 GO:0071493 8 cellular response to UV-B 3 4 1 1 1 0 0 0 69 4 2474 0.8959 1.0 1.0 0.0 0 0 0 0 0 GO:0071503 5 response to heparin 1 1 1 1 1 0 0 0 69 1 2477 0.97291 1.0 1.0 0.0 0 0 0 0 0 GO:0071504 6 cellular response to heparin 1 1 1 1 1 0 0 0 69 1 2477 0.97291 1.0 1.0 0.0 0 0 0 0 0 GO:0071505 5 response to mycophenolic acid 2 2 1 1 1 0 0 0 69 2 2476 0.94654 1.0 1.0 0.0 0 0 0 0 0 GO:0071506 6 cellular response to mycophenolic acid 2 2 1 1 1 0 0 0 69 2 2476 0.94654 1.0 1.0 0.0 0 0 0 0 0 GO:0071615 4 oxidative deethylation 1 1 1 1 0 1 0 0 69 1 2477 0.97291 1.0 1.0 0.0 0 0 0 0 0 GO:0071692 5 protein localization to extracellular region 27 29 1 1 0 1 0 0 69 29 2449 0.44891 1.0 1.0 0.0 0 0 0 0 0 GO:0071695 4 anatomical structure maturation 44 46 2 2 2 0 0 0 69 46 2432 0.27948 1.0 0.6354 0.0 0 0 0 0 0 GO:0071732 6 cellular response to nitric oxide 7 7 1 1 1 0 0 0 69 7 2471 0.82491 1.0 1.0 0.0 0 0 0 0 0 GO:0071850 7 mitotic cell cycle arrest 4 4 1 1 1 0 0 0 69 4 2474 0.8959 1.0 1.0 0.0 0 0 0 0 0 GO:0071867 6 response to monoamine 19 21 3 3 1 2 0 0 69 21 2457 0.56042 1.0 1.0 0.0 0 0 0 0 0 GO:0071868 6 cellular response to monoamine stimulus 14 14 1 1 0 1 0 0 69 14 2464 0.68011 1.0 1.0 0.0 0 0 0 0 0 GO:0071869 5 response to catecholamine 18 20 3 3 1 2 0 0 69 20 2458 0.57616 1.0 1.0 0.0 0 0 0 0 0 GO:0071870 6 cellular response to catecholamine stimulus 14 14 1 1 0 1 0 0 69 14 2464 0.68011 1.0 1.0 0.0 0 0 0 0 0 GO:0071871 6 response to epinephrine 8 9 1 1 0 1 0 0 69 9 2469 0.78069 1.0 1.0 0.0 0 0 0 0 0 GO:0071872 7 cellular response to epinephrine stimulus 5 5 1 1 0 1 0 0 69 5 2473 0.87159 1.0 1.0 0.0 0 0 0 0 0 GO:0071873 6 response to norepinephrine 5 6 2 2 1 1 0 0 69 6 2472 0.84794 1.0 1.0 0.0 0 0 0 0 0 GO:0071887 6 leukocyte apoptotic process 16 18 1 1 0 1 0 0 69 18 2460 0.60894 1.0 1.0 0.0 0 0 0 0 0 GO:0071918 5 urea transmembrane transport 2 2 1 1 0 1 0 0 69 2 2476 0.94654 1.0 1.0 0.0 0 0 0 0 0 GO:0072091 6 regulation of stem cell proliferation 19 21 1 1 1 0 0 0 69 21 2457 0.56042 1.0 1.0 0.0 0 0 0 0 0 GO:0072110 5 glomerular mesangial cell proliferation 2 2 1 1 1 0 0 0 69 2 2476 0.94654 1.0 1.0 0.0 0 0 0 0 0 GO:0072111 4 cell proliferation involved in kidney development 3 3 1 1 1 0 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:0072124 7 regulation of glomerular mesangial cell proliferation 6 6 1 1 1 0 0 0 69 6 2472 0.84794 1.0 1.0 0.0 0 0 0 0 0 GO:0072126 7 positive regulation of glomerular mesangial cell proliferation 3 3 1 1 1 0 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:0072215 7 regulation of metanephros development 10 10 1 1 1 0 0 0 69 10 2468 0.75947 1.0 1.0 0.0 0 0 0 0 0 GO:0072216 7 positive regulation of metanephros development 8 8 1 1 1 0 0 0 69 8 2470 0.8025 1.0 1.0 0.0 0 0 0 0 0 GO:0072298 7 regulation of metanephric glomerulus development 3 3 1 1 1 0 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:0072300 8 positive regulation of metanephric glomerulus development 3 3 1 1 1 0 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:0072301 8 regulation of metanephric glomerular mesangial cell proliferation 1 1 1 1 1 0 0 0 69 1 2477 0.97291 1.0 1.0 0.0 0 0 0 0 0 GO:0072303 8 positive regulation of glomerular metanephric mesangial cell proliferation 1 1 1 1 1 0 0 0 69 1 2477 0.97291 1.0 1.0 0.0 0 0 0 0 0 GO:0072331 6 signal transduction by p53 class mediator 28 29 2 2 2 0 0 0 69 29 2449 0.44891 1.0 1.0 0.0 0 0 0 0 0 GO:0072332 7 intrinsic apoptotic signaling pathway by p53 class mediator 19 19 2 2 2 0 0 0 69 19 2459 0.59232 1.0 1.0 0.0 0 0 0 0 0 GO:0072347 5 response to anesthetic 42 44 2 2 2 0 0 0 69 44 2434 0.29556 1.0 0.6315 0.0 0 0 0 0 0 GO:0072395 6 signal transduction involved in cell cycle checkpoint 10 10 1 1 1 0 0 0 69 10 2468 0.75947 1.0 1.0 0.0 0 0 0 0 0 GO:0072401 7 signal transduction involved in DNA integrity checkpoint 10 10 1 1 1 0 0 0 69 10 2468 0.75947 1.0 1.0 0.0 0 0 0 0 0 GO:0072413 7 signal transduction involved in mitotic cell cycle checkpoint 6 6 1 1 1 0 0 0 69 6 2472 0.84794 1.0 1.0 0.0 0 0 0 0 0 GO:0072422 7 signal transduction involved in DNA damage checkpoint 10 10 1 1 1 0 0 0 69 10 2468 0.75947 1.0 1.0 0.0 0 0 0 0 0 GO:0072431 9 signal transduction involved in mitotic G1 DNA damage checkpoint 5 5 1 1 1 0 0 0 69 5 2473 0.87159 1.0 1.0 0.0 0 0 0 0 0 GO:0072530 5 purine-containing compound transmembrane transport 1 1 1 1 0 1 0 0 69 1 2477 0.97291 1.0 1.0 0.0 0 0 0 0 0 GO:0072531 5 pyrimidine-containing compound transmembrane transport 1 1 1 1 0 1 0 0 69 1 2477 0.97291 1.0 1.0 0.0 0 0 0 0 0 GO:0072574 6 hepatocyte proliferation 5 5 3 3 1 2 0 0 69 5 2473 0.87159 1.0 1.0 0.0 0 0 0 0 0 GO:0072575 5 epithelial cell proliferation involved in liver morphogenesis 5 5 3 3 1 2 0 0 69 5 2473 0.87159 1.0 1.0 0.0 0 0 0 0 0 GO:0072594 6 establishment of protein localization to organelle 64 68 1 1 1 0 0 0 69 68 2410 0.15063 1.0 0.2609 0.0 0 0 0 0 0 GO:0072615 7 interleukin-17 secretion 1 1 1 1 0 1 0 0 69 1 2477 0.97291 1.0 1.0 0.0 0 0 0 0 0 GO:0080184 6 response to phenylpropanoid 9 9 1 1 0 1 0 0 69 9 2469 0.78069 1.0 1.0 0.0 0 0 0 0 0 GO:0090030 7 regulation of steroid hormone biosynthetic process 9 9 1 1 1 0 0 0 69 9 2469 0.78069 1.0 1.0 0.0 0 0 0 0 0 GO:0090031 8 positive regulation of steroid hormone biosynthetic process 6 6 1 1 1 0 0 0 69 6 2472 0.84794 1.0 1.0 0.0 0 0 0 0 0 GO:0090063 9 positive regulation of microtubule nucleation 2 2 1 1 1 0 0 0 69 2 2476 0.94654 1.0 1.0 0.0 0 0 0 0 0 GO:0090083 6 regulation of inclusion body assembly 9 9 1 1 1 0 0 0 69 9 2469 0.78069 1.0 1.0 0.0 0 0 0 0 0 GO:0090084 7 negative regulation of inclusion body assembly 7 7 1 1 1 0 0 0 69 7 2471 0.82491 1.0 1.0 0.0 0 0 0 0 0 GO:0090090 8 negative regulation of canonical Wnt signaling pathway 23 23 1 1 1 0 0 0 69 23 2455 0.53022 1.0 1.0 0.0 0 0 0 0 0 GO:0090128 7 regulation of synapse maturation 5 5 1 1 1 0 0 0 69 5 2473 0.87159 1.0 1.0 0.0 0 0 0 0 0 GO:0090129 7 positive regulation of synapse maturation 2 2 1 1 1 0 0 0 69 2 2476 0.94654 1.0 1.0 0.0 0 0 0 0 0 GO:0090169 7 regulation of spindle assembly 6 6 1 1 1 0 0 0 69 6 2472 0.84794 1.0 1.0 0.0 0 0 0 0 0 GO:0090183 6 regulation of kidney development 20 20 1 1 1 0 0 0 69 20 2458 0.57616 1.0 1.0 0.0 0 0 0 0 0 GO:0090184 6 positive regulation of kidney development 16 16 1 1 1 0 0 0 69 16 2462 0.64355 1.0 1.0 0.0 0 0 0 0 0 GO:0090192 7 regulation of glomerulus development 8 8 1 1 1 0 0 0 69 8 2470 0.8025 1.0 1.0 0.0 0 0 0 0 0 GO:0090193 7 positive regulation of glomerulus development 5 5 1 1 1 0 0 0 69 5 2473 0.87159 1.0 1.0 0.0 0 0 0 0 0 GO:0090224 7 regulation of spindle organization 11 11 1 1 1 0 0 0 69 11 2467 0.73881 1.0 1.0 0.0 0 0 0 0 0 GO:0090231 7 regulation of spindle checkpoint 3 3 1 1 1 0 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:0090232 7 positive regulation of spindle checkpoint 1 1 1 1 1 0 0 0 69 1 2477 0.97291 1.0 1.0 0.0 0 0 0 0 0 GO:0090257 6 regulation of muscle system process 64 65 1 1 1 0 0 0 69 65 2413 0.16393 1.0 0.42101 0.0 0 0 0 0 0 GO:0090263 8 positive regulation of canonical Wnt signaling pathway 20 22 1 1 1 0 0 0 69 22 2456 0.54512 1.0 1.0 0.0 0 0 0 0 0 GO:0090266 8 regulation of mitotic cell cycle spindle assembly checkpoint 3 3 1 1 1 0 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:0090267 8 positive regulation of mitotic cell cycle spindle assembly checkpoint 1 1 1 1 1 0 0 0 69 1 2477 0.97291 1.0 1.0 0.0 0 0 0 0 0 GO:0090278 7 negative regulation of peptide hormone secretion 13 14 1 1 1 0 0 0 69 14 2464 0.68011 1.0 1.0 0.0 0 0 0 0 0 GO:0090306 6 spindle assembly involved in meiosis 3 3 1 1 1 0 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:0090307 6 mitotic spindle assembly 10 10 1 1 1 0 0 0 69 10 2468 0.75947 1.0 1.0 0.0 0 0 0 0 0 GO:0090316 7 positive regulation of intracellular protein transport 45 48 1 1 1 0 0 0 69 48 2430 0.26427 1.0 0.63996 0.0 0 0 0 0 0 GO:0090342 5 regulation of cell aging 10 12 1 1 1 0 0 0 69 12 2466 0.71871 1.0 1.0 0.0 0 0 0 0 0 GO:0090344 6 negative regulation of cell aging 4 6 1 1 1 0 0 0 69 6 2472 0.84794 1.0 1.0 0.0 0 0 0 0 0 GO:0090398 5 cellular senescence 15 15 1 1 1 0 0 0 69 15 2463 0.66158 1.0 1.0 0.0 0 0 0 0 0 GO:0090399 5 replicative senescence 5 5 1 1 1 0 0 0 69 5 2473 0.87159 1.0 1.0 0.0 0 0 0 0 0 GO:0090520 5 sphingolipid mediated signaling pathway 2 2 1 1 1 0 0 0 69 2 2476 0.94654 1.0 1.0 0.0 0 0 0 0 0 GO:0090630 8 activation of GTPase activity 11 13 1 1 1 0 0 0 69 13 2465 0.69915 1.0 1.0 0.0 0 0 0 0 0 GO:0097150 4 neuronal stem cell population maintenance 9 9 1 1 1 0 0 0 69 9 2469 0.78069 1.0 1.0 0.0 0 0 0 0 0 GO:0097164 4 ammonium ion metabolic process 9 10 1 1 0 1 0 0 69 10 2468 0.75947 1.0 1.0 0.0 0 0 0 0 0 GO:0097201 9 negative regulation of transcription from RNA polymerase II promoter in response to stress 8 8 1 1 1 0 0 0 69 8 2470 0.8025 1.0 1.0 0.0 0 0 0 0 0 GO:0097742 6 de novo centriole assembly 1 1 1 1 1 0 0 0 69 1 2477 0.97291 1.0 1.0 0.0 0 0 0 0 0 GO:0097756 7 negative regulation of blood vessel diameter 12 13 2 2 2 0 0 0 69 13 2465 0.69915 1.0 1.0 0.0 0 0 0 0 0 GO:0098534 5 centriole assembly 5 5 1 1 1 0 0 0 69 5 2473 0.87159 1.0 1.0 0.0 0 0 0 0 0 GO:0098535 7 de novo centriole assembly involved in multi-ciliated epithelial cell differentiation 1 1 1 1 1 0 0 0 69 1 2477 0.97291 1.0 1.0 0.0 0 0 0 0 0 GO:0098706 9 iron ion import across cell outer membrane 1 1 1 1 1 0 0 0 69 1 2477 0.97291 1.0 1.0 0.0 0 0 0 0 0 GO:0098727 3 maintenance of cell number 28 29 1 1 1 0 0 0 69 29 2449 0.44891 1.0 1.0 0.0 0 0 0 0 0 GO:0098742 5 cell-cell adhesion via plasma-membrane adhesion molecules 29 30 1 1 1 0 0 0 69 30 2448 0.43661 1.0 1.0 0.0 0 0 0 0 0 GO:0098758 6 response to interleukin-8 1 1 1 1 1 0 0 0 69 1 2477 0.97291 1.0 1.0 0.0 0 0 0 0 0 GO:0098759 7 cellular response to interleukin-8 1 1 1 1 1 0 0 0 69 1 2477 0.97291 1.0 1.0 0.0 0 0 0 0 0 GO:0098856 6 intestinal lipid absorption 3 3 1 1 1 0 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:0099177 5 regulation of trans-synaptic signaling 117 127 3 3 2 1 0 0 69 127 2351 0.027917 1.0 0.047614 0.0 0 0 0 0 0 GO:0110020 7 regulation of actomyosin structure organization 31 34 4 4 3 0 0 0 69 34 2444 0.39064 1.0 1.0 0.0 0 0 0 0 0 GO:0110053 7 regulation of actin filament organization 56 59 3 3 2 0 0 0 69 59 2419 0.1941 1.0 0.40753 0.0 0 0 0 0 0 GO:0120031 7 plasma membrane bounded cell projection assembly 36 38 2 1 1 0 0 0 69 38 2440 0.34944 1.0 0.62464 0.0 0 0 0 0 0 GO:0120178 6 steroid hormone biosynthetic process 11 13 2 2 1 1 0 0 69 13 2465 0.69915 1.0 1.0 0.0 0 0 0 0 0 GO:0120188 7 regulation of bile acid secretion 7 8 3 3 2 1 0 0 69 8 2470 0.8025 1.0 1.0 0.0 0 0 0 0 0 GO:0120192 8 tight junction assembly 10 10 1 1 1 0 0 0 69 10 2468 0.75947 1.0 1.0 0.0 0 0 0 0 0 GO:0120193 7 tight junction organization 10 10 1 1 1 0 0 0 69 10 2468 0.75947 1.0 1.0 0.0 0 0 0 0 0 GO:0140039 5 cell-cell adhesion in response to extracellular stimulus 1 1 1 1 1 0 0 0 69 1 2477 0.97291 1.0 1.0 0.0 0 0 0 0 0 GO:0150115 6 cell-substrate junction organization 11 11 1 1 0 0 0 0 69 11 2467 0.73881 1.0 1.0 0.0 0 0 0 0 0 GO:1900024 7 regulation of substrate adhesion-dependent cell spreading 16 18 1 1 1 0 0 0 69 18 2460 0.60894 1.0 1.0 0.0 0 0 0 0 0 GO:1900026 8 positive regulation of substrate adhesion-dependent cell spreading 12 14 1 1 1 0 0 0 69 14 2464 0.68011 1.0 1.0 0.0 0 0 0 0 0 GO:1900078 6 positive regulation of cellular response to insulin stimulus 7 7 1 1 0 1 0 0 69 7 2471 0.82491 1.0 1.0 0.0 0 0 0 0 0 GO:1900117 8 regulation of execution phase of apoptosis 8 9 1 1 1 0 0 0 69 9 2469 0.78069 1.0 1.0 0.0 0 0 0 0 0 GO:1900119 9 positive regulation of execution phase of apoptosis 5 6 1 1 1 0 0 0 69 6 2472 0.84794 1.0 1.0 0.0 0 0 0 0 0 GO:1900180 7 regulation of protein localization to nucleus 47 51 1 1 1 0 0 0 69 51 2427 0.24297 1.0 0.40139 0.0 0 0 0 0 0 GO:1900182 7 positive regulation of protein localization to nucleus 32 34 1 1 1 0 0 0 69 34 2444 0.39064 1.0 1.0 0.0 0 0 0 0 0 GO:1900193 7 regulation of oocyte maturation 11 12 1 1 1 0 0 0 69 12 2466 0.71871 1.0 1.0 0.0 0 0 0 0 0 GO:1900195 8 positive regulation of oocyte maturation 7 7 1 1 1 0 0 0 69 7 2471 0.82491 1.0 1.0 0.0 0 0 0 0 0 GO:1900221 5 regulation of amyloid-beta clearance 8 9 1 1 1 0 0 0 69 9 2469 0.78069 1.0 1.0 0.0 0 0 0 0 0 GO:1900222 6 negative regulation of amyloid-beta clearance 5 6 1 1 1 0 0 0 69 6 2472 0.84794 1.0 1.0 0.0 0 0 0 0 0 GO:1900424 6 regulation of defense response to bacterium 2 2 1 1 0 1 0 0 69 2 2476 0.94654 1.0 1.0 0.0 0 0 0 0 0 GO:1900426 7 positive regulation of defense response to bacterium 2 2 1 1 0 1 0 0 69 2 2476 0.94654 1.0 1.0 0.0 0 0 0 0 0 GO:1900542 7 regulation of purine nucleotide metabolic process 30 32 1 1 1 0 0 0 69 32 2446 0.41299 1.0 1.0 0.0 0 0 0 0 0 GO:1900543 8 negative regulation of purine nucleotide metabolic process 8 8 1 1 1 0 0 0 69 8 2470 0.8025 1.0 1.0 0.0 0 0 0 0 0 GO:1901019 7 regulation of calcium ion transmembrane transporter activity 17 18 1 1 0 1 0 0 69 18 2460 0.60894 1.0 1.0 0.0 0 0 0 0 0 GO:1901020 7 negative regulation of calcium ion transmembrane transporter activity 6 7 1 1 0 1 0 0 69 7 2471 0.82491 1.0 1.0 0.0 0 0 0 0 0 GO:1901021 7 positive regulation of calcium ion transmembrane transporter activity 11 11 1 1 0 1 0 0 69 11 2467 0.73881 1.0 1.0 0.0 0 0 0 0 0 GO:1901099 7 negative regulation of signal transduction in absence of ligand 13 14 1 1 1 0 0 0 69 14 2464 0.68011 1.0 1.0 0.0 0 0 0 0 0 GO:1901160 5 primary amino compound metabolic process 5 6 1 1 0 1 0 0 69 6 2472 0.84794 1.0 1.0 0.0 0 0 0 0 0 GO:1901216 7 positive regulation of neuron death 58 61 4 4 2 1 0 0 69 61 2417 0.18348 1.0 0.41128 0.0 0 0 0 0 0 GO:1901264 6 carbohydrate derivative transport 18 18 1 0 0 1 0 0 69 18 2460 0.60894 1.0 1.0 0.0 0 0 0 0 0 GO:1901550 7 regulation of endothelial cell development 8 9 1 1 1 0 0 0 69 9 2469 0.78069 1.0 1.0 0.0 0 0 0 0 0 GO:1901551 8 negative regulation of endothelial cell development 2 2 1 1 1 0 0 0 69 2 2476 0.94654 1.0 1.0 0.0 0 0 0 0 0 GO:1901557 5 response to fenofibrate 1 1 1 1 0 1 0 0 69 1 2477 0.97291 1.0 1.0 0.0 0 0 0 0 0 GO:1901569 5 fatty acid derivative catabolic process 3 4 1 1 1 0 0 0 69 4 2474 0.8959 1.0 1.0 0.0 0 0 0 0 0 GO:1901616 5 organic hydroxy compound catabolic process 18 19 1 1 1 0 0 0 69 19 2459 0.59232 1.0 1.0 0.0 0 0 0 0 0 GO:1901673 8 regulation of mitotic spindle assembly 5 5 1 1 1 0 0 0 69 5 2473 0.87159 1.0 1.0 0.0 0 0 0 0 0 GO:1901722 6 regulation of cell proliferation involved in kidney development 8 8 1 1 1 0 0 0 69 8 2470 0.8025 1.0 1.0 0.0 0 0 0 0 0 GO:1901724 7 positive regulation of cell proliferation involved in kidney development 4 4 1 1 1 0 0 0 69 4 2474 0.8959 1.0 1.0 0.0 0 0 0 0 0 GO:1901739 7 regulation of myoblast fusion 11 11 1 1 1 0 0 0 69 11 2467 0.73881 1.0 1.0 0.0 0 0 0 0 0 GO:1901741 7 positive regulation of myoblast fusion 8 8 1 1 1 0 0 0 69 8 2470 0.8025 1.0 1.0 0.0 0 0 0 0 0 GO:1901862 6 negative regulation of muscle tissue development 21 21 1 1 1 0 0 0 69 21 2457 0.56042 1.0 1.0 0.0 0 0 0 0 0 GO:1901863 6 positive regulation of muscle tissue development 31 33 1 1 1 0 0 0 69 33 2445 0.40166 1.0 1.0 0.0 0 0 0 0 0 GO:1901879 7 regulation of protein depolymerization 15 16 1 1 1 0 0 0 69 16 2462 0.64355 1.0 1.0 0.0 0 0 0 0 0 GO:1901880 8 negative regulation of protein depolymerization 12 13 1 1 1 0 0 0 69 13 2465 0.69915 1.0 1.0 0.0 0 0 0 0 0 GO:1901976 6 regulation of cell cycle checkpoint 6 6 1 1 1 0 0 0 69 6 2472 0.84794 1.0 1.0 0.0 0 0 0 0 0 GO:1901978 6 positive regulation of cell cycle checkpoint 1 1 1 1 1 0 0 0 69 1 2477 0.97291 1.0 1.0 0.0 0 0 0 0 0 GO:1901988 8 negative regulation of cell cycle phase transition 40 41 3 3 3 0 0 0 69 41 2437 0.32139 1.0 0.62707 0.0 0 0 0 0 0 GO:1901991 8 negative regulation of mitotic cell cycle phase transition 37 38 3 3 3 0 0 0 69 38 2440 0.34944 1.0 0.62464 0.0 0 0 0 0 0 GO:1902099 7 regulation of metaphase/anaphase transition of cell cycle 15 15 1 1 1 0 0 0 69 15 2463 0.66158 1.0 1.0 0.0 0 0 0 0 0 GO:1902100 8 negative regulation of metaphase/anaphase transition of cell cycle 10 10 1 1 1 0 0 0 69 10 2468 0.75947 1.0 1.0 0.0 0 0 0 0 0 GO:1902107 7 positive regulation of leukocyte differentiation 58 62 2 2 0 2 0 0 69 62 2416 0.17839 1.0 0.41345 0.0 0 0 0 0 0 GO:1902115 6 regulation of organelle assembly 42 45 2 2 2 0 0 0 69 45 2433 0.28741 1.0 0.63336 0.0 0 0 0 0 0 GO:1902117 7 positive regulation of organelle assembly 16 18 1 1 1 0 0 0 69 18 2460 0.60894 1.0 1.0 0.0 0 0 0 0 0 GO:1902168 6 response to catechin 1 1 1 1 0 1 0 0 69 1 2477 0.97291 1.0 1.0 0.0 0 0 0 0 0 GO:1902170 6 cellular response to reactive nitrogen species 9 9 1 1 1 0 0 0 69 9 2469 0.78069 1.0 1.0 0.0 0 0 0 0 0 GO:1902224 5 ketone body metabolic process 3 3 1 1 1 0 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:1902235 7 regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 10 10 1 1 1 0 0 0 69 10 2468 0.75947 1.0 1.0 0.0 0 0 0 0 0 GO:1902236 7 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway 8 8 1 1 1 0 0 0 69 8 2470 0.8025 1.0 1.0 0.0 0 0 0 0 0 GO:1902275 8 regulation of chromatin organization 37 37 1 1 1 0 0 0 69 37 2441 0.35932 1.0 0.62434 0.0 0 0 0 0 0 GO:1902380 8 positive regulation of endoribonuclease activity 2 2 1 1 1 0 0 0 69 2 2476 0.94654 1.0 1.0 0.0 0 0 0 0 0 GO:1902400 8 intracellular signal transduction involved in G1 DNA damage checkpoint 5 5 1 1 1 0 0 0 69 5 2473 0.87159 1.0 1.0 0.0 0 0 0 0 0 GO:1902402 8 signal transduction involved in mitotic DNA damage checkpoint 6 6 1 1 1 0 0 0 69 6 2472 0.84794 1.0 1.0 0.0 0 0 0 0 0 GO:1902403 8 signal transduction involved in mitotic DNA integrity checkpoint 6 6 1 1 1 0 0 0 69 6 2472 0.84794 1.0 1.0 0.0 0 0 0 0 0 GO:1902510 6 regulation of apoptotic DNA fragmentation 5 5 1 1 1 0 0 0 69 5 2473 0.87159 1.0 1.0 0.0 0 0 0 0 0 GO:1902512 7 positive regulation of apoptotic DNA fragmentation 3 3 1 1 1 0 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:1902514 9 regulation of calcium ion transmembrane transport via high voltage-gated calcium channel 3 3 1 1 1 0 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:1902692 7 regulation of neuroblast proliferation 10 11 1 1 1 0 0 0 69 11 2467 0.73881 1.0 1.0 0.0 0 0 0 0 0 GO:1902713 7 regulation of interferon-gamma secretion 2 3 1 1 0 1 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:1902714 7 negative regulation of interferon-gamma secretion 1 1 1 1 0 1 0 0 69 1 2477 0.97291 1.0 1.0 0.0 0 0 0 0 0 GO:1902749 8 regulation of cell cycle G2/M phase transition 30 32 1 1 1 0 0 0 69 32 2446 0.41299 1.0 1.0 0.0 0 0 0 0 0 GO:1902750 9 negative regulation of cell cycle G2/M phase transition 15 16 1 1 1 0 0 0 69 16 2462 0.64355 1.0 1.0 0.0 0 0 0 0 0 GO:1902767 6 isoprenoid biosynthetic process via mevalonate 3 3 1 1 1 0 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:1902807 9 negative regulation of cell cycle G1/S phase transition 19 19 2 2 2 0 0 0 69 19 2459 0.59232 1.0 1.0 0.0 0 0 0 0 0 GO:1902850 6 microtubule cytoskeleton organization involved in mitosis 28 28 4 4 4 0 0 0 69 28 2450 0.46155 1.0 1.0 0.0 0 0 0 0 0 GO:1902893 9 regulation of pri-miRNA transcription by RNA polymerase II 35 36 1 1 1 0 0 0 69 36 2442 0.36948 1.0 0.62432 0.0 0 0 0 0 0 GO:1902895 10 positive regulation of pri-miRNA transcription by RNA polymerase II 28 29 1 1 1 0 0 0 69 29 2449 0.44891 1.0 1.0 0.0 0 0 0 0 0 GO:1902903 6 regulation of supramolecular fiber organization 89 94 5 5 4 0 0 0 69 94 2384 0.072031 1.0 0.18056 0.0 0 0 0 0 0 GO:1902904 7 negative regulation of supramolecular fiber organization 31 35 2 2 2 0 0 0 69 35 2443 0.37991 1.0 1.0 0.0 0 0 0 0 0 GO:1902905 7 positive regulation of supramolecular fiber organization 50 53 3 3 2 0 0 0 69 53 2425 0.22972 1.0 0.40146 0.0 0 0 0 0 0 GO:1902947 8 regulation of tau-protein kinase activity 9 10 1 1 1 0 0 0 69 10 2468 0.75947 1.0 1.0 0.0 0 0 0 0 0 GO:1902949 9 positive regulation of tau-protein kinase activity 3 4 1 1 1 0 0 0 69 4 2474 0.8959 1.0 1.0 0.0 0 0 0 0 0 GO:1902994 8 regulation of phospholipid efflux 2 2 1 1 1 0 0 0 69 2 2476 0.94654 1.0 1.0 0.0 0 0 0 0 0 GO:1902995 8 positive regulation of phospholipid efflux 2 2 1 1 1 0 0 0 69 2 2476 0.94654 1.0 1.0 0.0 0 0 0 0 0 GO:1903039 8 positive regulation of leukocyte cell-cell adhesion 73 77 2 2 1 1 0 0 69 77 2401 0.11679 1.0 0.27036 0.0 0 0 0 0 0 GO:1903140 8 regulation of establishment of endothelial barrier 8 9 1 1 1 0 0 0 69 9 2469 0.78069 1.0 1.0 0.0 0 0 0 0 0 GO:1903141 9 negative regulation of establishment of endothelial barrier 2 2 1 1 1 0 0 0 69 2 2476 0.94654 1.0 1.0 0.0 0 0 0 0 0 GO:1903169 8 regulation of calcium ion transmembrane transport 41 43 3 3 1 2 0 0 69 43 2435 0.30393 1.0 0.62982 0.0 0 0 0 0 0 GO:1903170 8 negative regulation of calcium ion transmembrane transport 9 10 1 1 0 1 0 0 69 10 2468 0.75947 1.0 1.0 0.0 0 0 0 0 0 GO:1903265 8 positive regulation of tumor necrosis factor-mediated signaling pathway 4 4 1 1 1 0 0 0 69 4 2474 0.8959 1.0 1.0 0.0 0 0 0 0 0 GO:1903314 6 regulation of nitrogen cycle metabolic process 1 1 1 1 0 1 0 0 69 1 2477 0.97291 1.0 1.0 0.0 0 0 0 0 0 GO:1903322 9 positive regulation of protein modification by small protein conjugation or removal 39 40 2 2 1 1 0 0 69 40 2438 0.33048 1.0 0.62602 0.0 0 0 0 0 0 GO:1903412 5 response to bile acid 2 2 1 1 0 1 0 0 69 2 2476 0.94654 1.0 1.0 0.0 0 0 0 0 0 GO:1903413 6 cellular response to bile acid 1 1 1 1 0 1 0 0 69 1 2477 0.97291 1.0 1.0 0.0 0 0 0 0 0 GO:1903429 7 regulation of cell maturation 18 19 1 1 1 0 0 0 69 19 2459 0.59232 1.0 1.0 0.0 0 0 0 0 0 GO:1903431 8 positive regulation of cell maturation 11 11 1 1 1 0 0 0 69 11 2467 0.73881 1.0 1.0 0.0 0 0 0 0 0 GO:1903504 7 regulation of mitotic spindle checkpoint 3 3 1 1 1 0 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:1903522 6 regulation of blood circulation 63 68 1 1 1 0 0 0 69 68 2410 0.15063 1.0 0.2609 0.0 0 0 0 0 0 GO:1903523 6 negative regulation of blood circulation 13 14 1 1 1 0 0 0 69 14 2464 0.68011 1.0 1.0 0.0 0 0 0 0 0 GO:1903531 6 negative regulation of secretion by cell 58 60 4 4 3 1 0 0 69 60 2418 0.18871 1.0 0.40931 0.0 0 0 0 0 0 GO:1903538 6 regulation of meiotic cell cycle process involved in oocyte maturation 9 10 1 1 1 0 0 0 69 10 2468 0.75947 1.0 1.0 0.0 0 0 0 0 0 GO:1903573 6 negative regulation of response to endoplasmic reticulum stress 18 18 1 1 1 0 0 0 69 18 2460 0.60894 1.0 1.0 0.0 0 0 0 0 0 GO:1903624 7 regulation of DNA catabolic process 6 6 1 1 1 0 0 0 69 6 2472 0.84794 1.0 1.0 0.0 0 0 0 0 0 GO:1903626 8 positive regulation of DNA catabolic process 3 3 1 1 1 0 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:1903725 7 regulation of phospholipid metabolic process 31 31 2 2 1 1 0 0 69 31 2447 0.42464 1.0 1.0 0.0 0 0 0 0 0 GO:1903727 7 positive regulation of phospholipid metabolic process 18 18 1 1 0 1 0 0 69 18 2460 0.60894 1.0 1.0 0.0 0 0 0 0 0 GO:1903793 7 positive regulation of anion transport 25 26 1 1 1 0 0 0 69 26 2452 0.4879 1.0 1.0 0.0 0 0 0 0 0 GO:1903829 6 positive regulation of cellular protein localization 83 90 1 1 1 0 0 0 69 90 2388 0.08073 1.0 0.175 0.0 0 0 0 0 0 GO:1903901 6 negative regulation of viral life cycle 23 24 1 1 1 0 0 0 69 24 2454 0.51572 1.0 1.0 0.0 0 0 0 0 0 GO:1904016 5 response to Thyroglobulin triiodothyronine 6 7 1 1 1 0 0 0 69 7 2471 0.82491 1.0 1.0 0.0 0 0 0 0 0 GO:1904017 5 cellular response to Thyroglobulin triiodothyronine 3 3 1 1 1 0 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:1904029 7 regulation of cyclin-dependent protein kinase activity 33 33 2 2 2 0 0 0 69 33 2445 0.40166 1.0 1.0 0.0 0 0 0 0 0 GO:1904030 8 negative regulation of cyclin-dependent protein kinase activity 8 8 1 1 1 0 0 0 69 8 2470 0.8025 1.0 1.0 0.0 0 0 0 0 0 GO:1904031 8 positive regulation of cyclin-dependent protein kinase activity 18 18 1 1 1 0 0 0 69 18 2460 0.60894 1.0 1.0 0.0 0 0 0 0 0 GO:1904044 6 response to aldosterone 5 6 1 1 0 1 0 0 69 6 2472 0.84794 1.0 1.0 0.0 0 0 0 0 0 GO:1904062 7 regulation of cation transmembrane transport 77 80 3 3 1 2 0 0 69 80 2398 0.10727 1.0 0.27655 0.0 0 0 0 0 0 GO:1904063 8 negative regulation of cation transmembrane transport 18 19 1 1 0 1 0 0 69 19 2459 0.59232 1.0 1.0 0.0 0 0 0 0 0 GO:1904064 8 positive regulation of cation transmembrane transport 36 38 2 2 1 1 0 0 69 38 2440 0.34944 1.0 0.62464 0.0 0 0 0 0 0 GO:1904146 7 positive regulation of meiotic cell cycle process involved in oocyte maturation 6 6 1 1 1 0 0 0 69 6 2472 0.84794 1.0 1.0 0.0 0 0 0 0 0 GO:1904177 6 regulation of adipose tissue development 2 2 1 1 0 1 0 0 69 2 2476 0.94654 1.0 1.0 0.0 0 0 0 0 0 GO:1904179 6 positive regulation of adipose tissue development 2 2 1 1 0 1 0 0 69 2 2476 0.94654 1.0 1.0 0.0 0 0 0 0 0 GO:1904251 6 regulation of bile acid metabolic process 5 6 2 2 2 0 0 0 69 6 2472 0.84794 1.0 1.0 0.0 0 0 0 0 0 GO:1904385 7 cellular response to angiotensin 13 13 1 1 0 1 0 0 69 13 2465 0.69915 1.0 1.0 0.0 0 0 0 0 0 GO:1904424 5 regulation of GTP binding 5 5 1 1 1 0 0 0 69 5 2473 0.87159 1.0 1.0 0.0 0 0 0 0 0 GO:1904427 8 positive regulation of calcium ion transmembrane transport 21 22 2 2 1 1 0 0 69 22 2456 0.54512 1.0 1.0 0.0 0 0 0 0 0 GO:1904468 7 negative regulation of tumor necrosis factor secretion 2 2 1 1 0 1 0 0 69 2 2476 0.94654 1.0 1.0 0.0 0 0 0 0 0 GO:1904480 6 positive regulation of intestinal absorption 1 1 1 1 1 0 0 0 69 1 2477 0.97291 1.0 1.0 0.0 0 0 0 0 0 GO:1904486 5 response to 17alpha-ethynylestradiol 6 6 2 2 1 1 0 0 69 6 2472 0.84794 1.0 1.0 0.0 0 0 0 0 0 GO:1904589 8 regulation of protein import 32 35 1 1 1 0 0 0 69 35 2443 0.37991 1.0 1.0 0.0 0 0 0 0 0 GO:1904591 7 positive regulation of protein import 23 24 1 1 1 0 0 0 69 24 2454 0.51572 1.0 1.0 0.0 0 0 0 0 0 GO:1904645 6 response to amyloid-beta 27 28 1 1 1 0 0 0 69 28 2450 0.46155 1.0 1.0 0.0 0 0 0 0 0 GO:1904646 7 cellular response to amyloid-beta 23 24 1 1 1 0 0 0 69 24 2454 0.51572 1.0 1.0 0.0 0 0 0 0 0 GO:1904666 9 regulation of ubiquitin protein ligase activity 6 6 2 2 2 0 0 0 69 6 2472 0.84794 1.0 1.0 0.0 0 0 0 0 0 GO:1904667 10 negative regulation of ubiquitin protein ligase activity 2 2 1 1 1 0 0 0 69 2 2476 0.94654 1.0 1.0 0.0 0 0 0 0 0 GO:1904668 10 positive regulation of ubiquitin protein ligase activity 3 3 1 1 1 0 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:1904731 7 positive regulation of intestinal lipid absorption 1 1 1 1 1 0 0 0 69 1 2477 0.97291 1.0 1.0 0.0 0 0 0 0 0 GO:1904823 6 purine nucleobase transmembrane transport 1 1 1 1 0 1 0 0 69 1 2477 0.97291 1.0 1.0 0.0 0 0 0 0 0 GO:1904844 5 response to L-glutamine 2 2 1 1 0 1 0 0 69 2 2476 0.94654 1.0 1.0 0.0 0 0 0 0 0 GO:1904845 6 cellular response to L-glutamine 2 2 1 1 0 1 0 0 69 2 2476 0.94654 1.0 1.0 0.0 0 0 0 0 0 GO:1904879 9 positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel 1 1 1 1 1 0 0 0 69 1 2477 0.97291 1.0 1.0 0.0 0 0 0 0 0 GO:1904880 5 response to hydrogen sulfide 3 3 1 1 0 0 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:1904893 7 negative regulation of receptor signaling pathway via STAT 8 8 1 1 1 0 0 0 69 8 2470 0.8025 1.0 1.0 0.0 0 0 0 0 0 GO:1905097 4 regulation of guanyl-nucleotide exchange factor activity 3 3 1 1 1 0 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:1905098 5 negative regulation of guanyl-nucleotide exchange factor activity 3 3 1 1 1 0 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:1905178 6 regulation of cardiac muscle tissue regeneration 2 2 1 1 1 0 0 0 69 2 2476 0.94654 1.0 1.0 0.0 0 0 0 0 0 GO:1905179 7 negative regulation of cardiac muscle tissue regeneration 2 2 1 1 1 0 0 0 69 2 2476 0.94654 1.0 1.0 0.0 0 0 0 0 0 GO:1905207 6 regulation of cardiocyte differentiation 23 24 1 1 1 0 0 0 69 24 2454 0.51572 1.0 1.0 0.0 0 0 0 0 0 GO:1905208 6 negative regulation of cardiocyte differentiation 9 9 1 1 1 0 0 0 69 9 2469 0.78069 1.0 1.0 0.0 0 0 0 0 0 GO:1905395 5 response to flavonoid 4 4 1 1 0 1 0 0 69 4 2474 0.8959 1.0 1.0 0.0 0 0 0 0 0 GO:1905693 8 regulation of phosphatidic acid biosynthetic process 1 1 1 1 0 1 0 0 69 1 2477 0.97291 1.0 1.0 0.0 0 0 0 0 0 GO:1905695 9 positive regulation of phosphatidic acid biosynthetic process 1 1 1 1 0 1 0 0 69 1 2477 0.97291 1.0 1.0 0.0 0 0 0 0 0 GO:1905784 11 regulation of anaphase-promoting complex-dependent catabolic process 1 1 1 1 1 0 0 0 69 1 2477 0.97291 1.0 1.0 0.0 0 0 0 0 0 GO:1905786 12 positive regulation of anaphase-promoting complex-dependent catabolic process 1 1 1 1 1 0 0 0 69 1 2477 0.97291 1.0 1.0 0.0 0 0 0 0 0 GO:1905818 6 regulation of chromosome separation 17 17 1 1 1 0 0 0 69 17 2461 0.62601 1.0 1.0 0.0 0 0 0 0 0 GO:1905819 7 negative regulation of chromosome separation 11 11 1 1 1 0 0 0 69 11 2467 0.73881 1.0 1.0 0.0 0 0 0 0 0 GO:1905879 5 regulation of oogenesis 12 13 1 1 1 0 0 0 69 13 2465 0.69915 1.0 1.0 0.0 0 0 0 0 0 GO:1905881 6 positive regulation of oogenesis 7 7 1 1 1 0 0 0 69 7 2471 0.82491 1.0 1.0 0.0 0 0 0 0 0 GO:1905897 6 regulation of response to endoplasmic reticulum stress 26 26 1 1 1 0 0 0 69 26 2452 0.4879 1.0 1.0 0.0 0 0 0 0 0 GO:1990314 7 cellular response to insulin-like growth factor stimulus 6 8 1 1 1 0 0 0 69 8 2470 0.8025 1.0 1.0 0.0 0 0 0 0 0 GO:1990418 5 response to insulin-like growth factor stimulus 4 4 1 1 1 0 0 0 69 4 2474 0.8959 1.0 1.0 0.0 0 0 0 0 0 GO:1990705 5 cholangiocyte proliferation 1 1 1 1 1 0 0 0 69 1 2477 0.97291 1.0 1.0 0.0 0 0 0 0 0 GO:1990776 6 response to angiotensin 20 20 1 1 0 1 0 0 69 20 2458 0.57616 1.0 1.0 0.0 0 0 0 0 0 GO:1990928 5 response to amino acid starvation 14 16 1 1 1 0 0 0 69 16 2462 0.64355 1.0 1.0 0.0 0 0 0 0 0 GO:2000134 9 negative regulation of G1/S transition of mitotic cell cycle 18 18 2 2 2 0 0 0 69 18 2460 0.60894 1.0 1.0 0.0 0 0 0 0 0 GO:2000177 6 regulation of neural precursor cell proliferation 27 29 2 2 2 0 0 0 69 29 2449 0.44891 1.0 1.0 0.0 0 0 0 0 0 GO:2000179 7 positive regulation of neural precursor cell proliferation 15 17 1 1 1 0 0 0 69 17 2461 0.62601 1.0 1.0 0.0 0 0 0 0 0 GO:2000182 7 regulation of progesterone biosynthetic process 2 2 1 1 1 0 0 0 69 2 2476 0.94654 1.0 1.0 0.0 0 0 0 0 0 GO:2000211 8 regulation of glutamate metabolic process 2 2 1 1 0 1 0 0 69 2 2476 0.94654 1.0 1.0 0.0 0 0 0 0 0 GO:2000213 8 positive regulation of glutamate metabolic process 1 1 1 1 0 1 0 0 69 1 2477 0.97291 1.0 1.0 0.0 0 0 0 0 0 GO:2000279 8 negative regulation of DNA biosynthetic process 13 13 1 1 1 0 0 0 69 13 2465 0.69915 1.0 1.0 0.0 0 0 0 0 0 GO:2000378 7 negative regulation of reactive oxygen species metabolic process 32 33 1 1 1 0 0 0 69 33 2445 0.40166 1.0 1.0 0.0 0 0 0 0 0 GO:2000431 6 regulation of cytokinesis, actomyosin contractile ring assembly 1 1 1 1 1 0 0 0 69 1 2477 0.97291 1.0 1.0 0.0 0 0 0 0 0 GO:2000648 7 positive regulation of stem cell proliferation 13 14 1 1 1 0 0 0 69 14 2464 0.68011 1.0 1.0 0.0 0 0 0 0 0 GO:2000725 7 regulation of cardiac muscle cell differentiation 21 22 1 1 1 0 0 0 69 22 2456 0.54512 1.0 1.0 0.0 0 0 0 0 0 GO:2000726 7 negative regulation of cardiac muscle cell differentiation 8 8 1 1 1 0 0 0 69 8 2470 0.8025 1.0 1.0 0.0 0 0 0 0 0 GO:2000772 6 regulation of cellular senescence 9 10 1 1 1 0 0 0 69 10 2468 0.75947 1.0 1.0 0.0 0 0 0 0 0 GO:2000773 6 negative regulation of cellular senescence 3 4 1 1 1 0 0 0 69 4 2474 0.8959 1.0 1.0 0.0 0 0 0 0 0 GO:2000816 8 negative regulation of mitotic sister chromatid separation 11 11 1 1 1 0 0 0 69 11 2467 0.73881 1.0 1.0 0.0 0 0 0 0 0 GO:2000843 6 regulation of testosterone secretion 2 2 1 1 1 0 0 0 69 2 2476 0.94654 1.0 1.0 0.0 0 0 0 0 0 GO:2000844 7 negative regulation of testosterone secretion 1 1 1 1 1 0 0 0 69 1 2477 0.97291 1.0 1.0 0.0 0 0 0 0 0 GO:2001138 7 regulation of phospholipid transport 4 4 1 1 1 0 0 0 69 4 2474 0.8959 1.0 1.0 0.0 0 0 0 0 0 GO:2001140 7 positive regulation of phospholipid transport 4 4 1 1 1 0 0 0 69 4 2474 0.8959 1.0 1.0 0.0 0 0 0 0 0 GO:2001240 8 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand 13 14 1 1 1 0 0 0 69 14 2464 0.68011 1.0 1.0 0.0 0 0 0 0 0 GO:2001248 7 regulation of ammonia assimilation cycle 1 1 1 1 0 1 0 0 69 1 2477 0.97291 1.0 1.0 0.0 0 0 0 0 0 GO:2001250 7 positive regulation of ammonia assimilation cycle 1 1 1 1 0 1 0 0 69 1 2477 0.97291 1.0 1.0 0.0 0 0 0 0 0 GO:2001257 7 regulation of cation channel activity 35 35 1 1 0 1 0 0 69 35 2443 0.37991 1.0 1.0 0.0 0 0 0 0 0 GO:2001258 7 negative regulation of cation channel activity 9 9 1 1 0 1 0 0 69 9 2469 0.78069 1.0 1.0 0.0 0 0 0 0 0 GO:2001259 7 positive regulation of cation channel activity 16 16 1 1 0 1 0 0 69 16 2462 0.64355 1.0 1.0 0.0 0 0 0 0 0 GO:0019184 7 nonribosomal peptide biosynthetic process 3 3 2 2 2 2 2 2 67 1 2477 0.99998 0.0021326 0.0021326 66.67 29739;25283 gclm;gclc GCLM_8700;GCLC_8699 168.09550000000002 168.09550000000002 145.958 31.30715273703435 168.44098844330304 31.303339885243552 82.96405 82.96405 69.2223 19.433769220740455 82.74958965823787 19.431402410753066 388.3185 388.3185 280.185 152.9238622468713 390.00608326748323 152.90523787604715 0.0 145.958 0.0 145.958 190.233;145.958 69.2223;96.7058 496.452;280.185 2 0 2 29739;25283 GCLM_8700;GCLC_8699 168.09550000000002 168.09550000000002 31.30715273703435 82.96405 82.96405 19.433769220740455 388.3185 388.3185 152.9238622468713 190.233;145.958 69.2223;96.7058 496.452;280.185 0 0 Hill,1(0.5);Poly 2,1(0.5) 1.8330735970857637 3.6691508293151855 1.7603585720062256 1.90879225730896 0.10495846543407344 1.8345754146575928 124.70600000000002 211.485 56.030220000000014 109.89787999999999 176.37684 600.2601599999999 UP 1.0 0.0 0.0 GO:0010949 8 negative regulation of intestinal phytosterol absorption 2 2 1 1 1 1 1 1 68 1 2477 0.99928 0.053458 0.053458 50.0 114628 abcg5 ABCG5_7947 565.363 565.363 565.363 565.363 386.851 386.851 386.851 386.851 1047.94 1047.94 1047.94 1047.94 0.0 565.363 0.0 565.363 565.363 386.851 1047.94 0 1 0 1 114628 ABCG5_7947 565.363 565.363 386.851 386.851 1047.94 1047.94 565.363 386.851 1047.94 0 Linear,1(1) 1.783576488494873 1.783576488494873 1.783576488494873 1.783576488494873 0.0 1.783576488494873 565.363 565.363 386.851 386.851 1047.94 1047.94 DOWN 0.0 1.0 0.0 GO:0045796 8 negative regulation of intestinal cholesterol absorption 2 2 1 1 1 1 1 1 68 1 2477 0.99928 0.053458 0.053458 50.0 114628 abcg5 ABCG5_7947 565.363 565.363 565.363 565.363 386.851 386.851 386.851 386.851 1047.94 1047.94 1047.94 1047.94 0.0 565.363 0.0 565.363 565.363 386.851 1047.94 0 1 0 1 114628 ABCG5_7947 565.363 565.363 386.851 386.851 1047.94 1047.94 565.363 386.851 1047.94 0 Linear,1(1) 1.783576488494873 1.783576488494873 1.783576488494873 1.783576488494873 0.0 1.783576488494873 565.363 565.363 386.851 386.851 1047.94 1047.94 DOWN 0.0 1.0 0.0 GO:0031670 5 cellular response to nutrient 30 32 4 4 3 3 2 2 67 30 2448 0.94609 0.21436 0.21436 6.25 59107;24539 ltbp1;lpl LTBP1_33264;LPL_32544 834.7560000000001 834.7560000000001 769.394 92.43582686382874 859.1282711864407 85.76926537186463 462.74649999999997 462.74649999999997 438.027 34.958652155082945 471.96394067796604 32.43740025335675 2819.79 2819.79 2211.2 860.6762319246413 3046.72186440678 798.6034272614443 0.5 834.7560000000001 769.394;900.118 438.027;487.466 2211.2;3428.38 0 2 0 2 59107;24539 LTBP1_33264;LPL_32544 834.7560000000001 834.7560000000001 92.43582686382874 462.74649999999997 462.74649999999997 34.958652155082945 2819.79 2819.79 860.6762319246413 769.394;900.118 438.027;487.466 2211.2;3428.38 0 Exp 2,2(1) 1.6060540733733604 3.2176997661590576 1.5140434503555298 1.7036563158035278 0.13407654295849183 1.6088498830795288 706.6464800000001 962.8655200000001 414.29627999999997 511.19671999999997 1626.9535999999998 4012.6264 DOWN 0.0 1.0 0.0 GO:0090287 5 regulation of cellular response to growth factor stimulus 62 66 5 5 5 3 3 3 66 63 2415 0.89848 0.26449 0.42386 4.55 338475;59107;25317 nrep;ltbp1;fgf1 NREP_9364;LTBP1_33264;FGF1_8633 544.9050000000001 674.162 191.159 310.03138202930353 533.1614328519078 286.7330777068828 330.5116666666667 437.622 115.886 185.8713899456646 336.15843378601704 183.1607305410612 1374.756 1465.0 448.068 885.0235008224356 1233.418092117554 713.3803047146712 191.159;769.394;674.162 115.886;438.027;437.622 448.068;2211.2;1465.0 1 2 1 25317 FGF1_8633 674.162 674.162 437.622 437.622 1465.0 1465.0 674.162 437.622 1465.0 2 338475;59107 NREP_9364;LTBP1_33264 480.2765 480.2765 408.87388961940326 276.9565 276.9565 227.7880855982156 1329.634 1329.634 1246.7225933269997 191.159;769.394 115.886;438.027 448.068;2211.2 0 Exp 2,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 1.759519159295568 5.375480651855469 1.5140434503555298 2.291023015975952 0.43323434607236183 1.5704141855239868 194.07146433117367 895.7385356688262 120.17838850789906 540.8449448254343 373.2576293796027 2376.2543706203974 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0044255 4 cellular lipid metabolic process 218 243 22 22 19 15 12 12 57 231 2247 0.98835 0.02744 0.035054 4.94 361042;24539;64194;84029;24426;24404;25315;171142;25426;24296;290277;24207 pck2;lpl;insig1;hao2;gstp1;gpx1;ephx1;ehhadh;cyp1b1;cyp1a1;cryl1;apoc3 PCK2_9440;LPL_32544;INSIG1_8906;HAO2_8778;GSTP1_8762;GPX1_33050;EPHX1_8567;EHHADH_8534;CYP1B1_32710;CYP1A1_8415;CRYL1_8388;APOC3_32553 146.52692166666668 60.34735 2.87451 248.2899712588646 112.4375057067619 194.27864439042057 88.84303583333333 39.23665 1.13737 137.78515234248047 71.74858780023006 112.85966643602372 420.0725925 110.5255 8.23841 955.2199956411433 283.8839804137055 717.6994868662473 6.67763;900.118;37.6554;140.856;122.514;8.00432;27.5708;166.899;229.313;83.0393;32.8011;2.87451 1.48195;487.466;13.2791;93.5219;84.8469;2.69961;12.6303;105.26;185.32;63.0271;15.4462;1.13737 37.9425;3428.38;101.065;282.925;216.573;25.2254;61.9858;384.658;299.27;119.986;74.622;8.23841 7 5 7 361042;64194;24426;25315;25426;24296;290277 PCK2_9440;INSIG1_8906;GSTP1_8762;EPHX1_8567;CYP1B1_32710;CYP1A1_8415;CRYL1_8388 77.08160428571429 37.6554 77.67155478906113 53.71879285714285 15.4462 65.69068107040519 130.20632857142857 101.065 94.20869673366526 6.67763;37.6554;122.514;27.5708;229.313;83.0393;32.8011 1.48195;13.2791;84.8469;12.6303;185.32;63.0271;15.4462 37.9425;101.065;216.573;61.9858;299.27;119.986;74.622 5 24539;84029;24404;171142;24207 LPL_32544;HAO2_8778;GPX1_33050;EHHADH_8534;APOC3_32553 243.75036600000004 140.856 374.4693679667713 138.016976 93.5219 201.3791621043226 825.885362 282.925 1463.904777757431 900.118;140.856;8.00432;166.899;2.87451 487.466;93.5219;2.69961;105.26;1.13737 3428.38;282.925;25.2254;384.658;8.23841 0 Exp 2,1(0.09);Exp 4,1(0.09);Exp 5,1(0.09);Hill,4(0.34);Linear,1(0.09);Poly 2,4(0.34) 2.424563164210789 32.93334150314331 1.5039241313934326 6.292444229125977 1.5974950471200173 2.0436903834342957 6.043645558144533 287.0101977751888 10.88374693397391 166.80232473269274 -120.3939986863528 960.5391836863527 CONFLICT 0.5833333333333334 0.4166666666666667 0.0 GO:0070301 6 cellular response to hydrogen peroxide 41 45 4 4 3 2 2 2 67 43 2435 0.8793 0.34595 0.34595 4.44 170496;25426 lcn2;cyp1b1 LCN2_32481;CYP1B1_32710 600.9694999999999 600.9694999999999 229.313 525.6016628441164 445.81963169499966 477.61296539602245 368.6255 368.6255 185.32 259.23312415758147 292.10370047656306 235.56451569769555 2191.92 2191.92 299.27 2676.6112988254386 1401.8237733835979 2432.2302420562587 972.626;229.313 551.931;185.32 4084.57;299.27 2 0 2 170496;25426 LCN2_32481;CYP1B1_32710 600.9694999999999 600.9694999999999 525.6016628441164 368.6255 368.6255 259.23312415758147 2191.92 2191.92 2676.6112988254386 972.626;229.313 551.931;185.32 4084.57;299.27 0 0 Linear,2(1) 2.431748041644652 5.041389107704163 1.856990933418274 3.1843981742858887 0.9386186614136153 2.5206945538520813 -127.47723999999994 1329.4162399999998 9.346719999999948 727.90428 -1517.6739999999995 5901.513999999999 UP 1.0 0.0 0.0 GO:0043086 5 negative regulation of catalytic activity 212 228 15 15 11 9 6 6 63 222 2256 0.57651 0.59334 1.0 2.63 299270;312538;288001;24426;24404;24207 serpina6;mcm2;kng1;gstp1;gpx1;apoc3 SERPINA6_32325;MCM2_9206;KNG1L1_32433;GSTP1_8762;GPX1_33050;APOC3_32553 288001(0.1788) 27.80192 5.93994 2.87451 47.19720117957122 13.465139753527811 26.89899796533506 16.511485500000003 1.97736 0.956203 33.58899327966365 6.311964790039865 18.422861715288068 65.01165166666668 24.07355 8.23841 82.01385793214472 40.69867927197368 55.48333650359363 25.7745;3.76863;3.87556;122.514;8.00432;2.87451 8.17372;0.956203;1.25511;84.8469;2.69961;1.13737 103.274;22.9217;13.8374;216.573;25.2254;8.23841 3 3 3 312538;288001;24426 MCM2_9206;KNG1L1_32433;GSTP1_8762 43.38606333333333 3.87556 68.5268241592242 29.019404333333338 1.25511 48.34826047188695 84.44403333333334 22.9217 114.517155924007 3.76863;3.87556;122.514 0.956203;1.25511;84.8469 22.9217;13.8374;216.573 3 299270;24404;24207 SERPINA6_32325;GPX1_33050;APOC3_32553 12.217776666666666 8.00432 12.017374851082634 4.003566666666667 2.69961 3.6949671949874374 45.57927 25.2254 50.68185927572804 25.7745;8.00432;2.87451 8.17372;2.69961;1.13737 103.274;25.2254;8.23841 0 Exp 4,2(0.34);Hill,3(0.5);Poly 2,1(0.17) 2.043813445003197 13.944376230239868 1.5235437154769897 5.5128583908081055 1.5739588138714873 1.680104672908783 -9.963706324628394 65.5675463246284 -10.365306706256739 43.38827770625674 -0.6131022318159864 130.63640556514935 CONFLICT 0.5 0.5 0.0 GO:0006869 6 lipid transport 73 76 12 12 9 7 4 4 65 72 2406 0.9472 0.14847 0.14847 5.26 29200;24207;301111;114628 inhba;apoc3;ano10;abcg5 INHBA_33300;APOC3_32553;ANO10_8049;ABCG5_7947 167.4921525 50.86555 2.87451 268.3012422738399 212.1568992567568 299.16631030707384 108.76606749999999 23.53795 1.13737 186.4522446762787 141.52784679981795 207.116167530866 319.0741775 110.05915 8.23841 492.2929616150029 399.0839316436774 550.1660350114563 2.5 328.5867 91.8104;2.87451;9.9207;565.363 44.1594;1.13737;2.9165;386.851 186.93;8.23841;33.1883;1047.94 1 3 1 301111 ANO10_8049 9.9207 9.9207 2.9165 2.9165 33.1883 33.1883 9.9207 2.9165 33.1883 3 29200;24207;114628 INHBA_33300;APOC3_32553;ABCG5_7947 220.01597 91.8104 302.36703934107754 144.04925666666665 44.1594 211.36990961489678 414.36947000000004 186.93 555.9149066606711 91.8104;2.87451;565.363 44.1594;1.13737;386.851 186.93;8.23841;1047.94 0 Exp 4,1(0.25);Hill,2(0.5);Linear,1(0.25) 1.7698998619719581 7.17482852935791 1.5235437154769897 2.2924909591674805 0.35100521627666165 1.67939692735672 -95.44306492836301 430.4273699283631 -73.9571322827531 291.4892672827531 -163.37292488270282 801.5212798827029 DOWN 0.25 0.75 0.0 GO:1901215 7 negative regulation of neuron death 102 106 4 4 4 4 4 4 65 102 2376 0.84287 0.32283 0.53146 3.77 24567;29739;25283;24890 mt1;gclm;gclc;esr1 MT1A_9255;GCLM_8700;GCLC_8699;ESR1_33192 291.766325 168.09550000000002 12.5403 359.07741649820093 161.63790641576864 233.56097424721236 177.4734775 82.96405 3.74981 244.95154992922858 88.99775554190632 155.53035303534543 454.10720000000003 388.3185 51.2968 399.94522661521205 313.6786384499414 303.4762652487811 818.334;190.233;145.958;12.5403 540.216;69.2223;96.7058;3.74981 988.495;496.452;280.185;51.2968 2 2 2 29739;25283 GCLM_8700;GCLC_8699 168.09550000000002 168.09550000000002 31.30715273703435 82.96405 82.96405 19.433769220740455 388.3185 388.3185 152.9238622468713 190.233;145.958 69.2223;96.7058 496.452;280.185 2 24567;24890 MT1A_9255;ESR1_33192 415.43715 415.43715 569.7821895073985 271.982905 271.982905 379.33888082631086 519.8959 519.8959 662.6992025358263 818.334;12.5403 540.216;3.74981 988.495;51.2968 0 Hill,2(0.5);Poly 2,2(0.5) 1.9203971195995955 7.738187074661255 1.7318620681762695 2.3371741771698 0.2794009905744321 1.8345754146575928 -60.12954316823698 643.662193168237 -62.579041430644 417.525996430644 62.16087791709219 846.0535220829079 CONFLICT 0.5 0.5 0.0 GO:0051188 5 cofactor biosynthetic process 48 53 9 9 7 8 6 6 63 47 2431 0.99955 0.0026695 0.0026695 11.32 116682;29739;25283;24296;25748;360887 kynu;gclm;gclc;cyp1a1;alas2;coq8a KYNU_8979;GCLM_8700;GCLC_8699;CYP1A1_8415;ALAS2_8019;ADCK3_7987 195.03155 135.732 83.0393 165.94741986911097 157.6427615840788 131.68043370186294 120.64916666666666 79.2569 63.0271 106.40486112699298 97.4402861728147 82.25672087995021 388.8268333333333 258.4735 119.986 344.11173876659115 310.01073102824404 286.0547748664072 1.5 112.9435 4.5 357.65250000000003 100.381;190.233;145.958;83.0393;125.506;525.072 72.7231;69.2223;96.7058;63.0271;85.7907;336.426 161.456;496.452;280.185;119.986;236.762;1038.12 3 3 3 29739;25283;24296 GCLM_8700;GCLC_8699;CYP1A1_8415 139.74343333333334 145.958 53.86638988333391 76.3184 69.2223 17.925671112401893 298.87433333333337 280.185 188.9275805019832 190.233;145.958;83.0393 69.2223;96.7058;63.0271 496.452;280.185;119.986 3 116682;25748;360887 KYNU_8979;ALAS2_8019;ADCK3_7987 250.31966666666668 125.506 238.27389682953802 164.97993333333332 85.7907 148.6203413871847 478.7793333333332 236.762 485.86441982237534 100.381;125.506;525.072 72.7231;85.7907;336.426 161.456;236.762;1038.12 0 Exp 2,1(0.17);Hill,1(0.17);Poly 2,4(0.67) 2.2068406336668818 15.264697909355164 1.5869897603988647 6.292444229125977 1.8409287359105955 1.8345754146575928 62.245959081831245 327.8171409181687 35.507545468472955 205.79078786486033 113.48009633651714 664.1735703301495 CONFLICT 0.5 0.5 0.0 GO:1901565 5 organonitrogen compound catabolic process 128 143 4 4 4 3 3 3 66 140 2338 0.45105 0.7552 1.0 2.1 116682;81508;296925 kynu;bhmt;aass KYNU_8979;BHMT_8143;AASS_7936 37.243786666666665 5.81076 5.5396 54.678598761860506 28.465200786007795 49.555519823743616 25.767666666666667 2.60489 1.97501 40.66581767091907 19.269176427141502 36.835196306510646 71.12236666666666 37.8319 14.0792 79.12756582078923 56.86077290591086 73.14237917257672 100.381;5.5396;5.81076 72.7231;1.97501;2.60489 161.456;37.8319;14.0792 0 3 0 3 116682;81508;296925 KYNU_8979;BHMT_8143;AASS_7936 37.243786666666665 5.81076 54.678598761860506 25.767666666666667 2.60489 40.66581767091907 71.12236666666666 37.8319 79.12756582078923 100.381;5.5396;5.81076 72.7231;1.97501;2.60489 161.456;37.8319;14.0792 0 Exp 4,1(0.34);Hill,1(0.34);Poly 2,1(0.34) 1.972757559405741 5.975060820579529 1.6724973917007446 2.3450815677642822 0.33759422247551973 1.957481861114502 -24.630872612913862 99.1184459462472 -20.250038060411214 71.78537139374454 -18.41890333016022 160.66363666349355 DOWN 0.0 1.0 0.0 GO:0006953 7 acute-phase response 25 27 3 3 2 3 2 2 67 25 2453 0.96503 0.16491 0.16491 7.41 24614;288001 orm1;kng1 ORM1_9400;KNG1L1_32433 288001(0.1788) 333.18278 333.18278 3.87556 465.7107367113806 228.99320301324 441.786774794014 216.850055 216.850055 1.25511 304.8972951980815 148.63792737026327 289.2344583682156 713.5786999999999 713.5786999999999 13.8374 989.5836366125806 492.18741059199505 938.7478723277629 0.5 333.18278 662.49;3.87556 432.445;1.25511 1413.32;13.8374 2 0 2 24614;288001 ORM1_9400;KNG1L1_32433 333.18278 333.18278 465.7107367113806 216.850055 216.850055 304.8972951980815 713.5786999999999 713.5786999999999 989.5836366125806 662.49;3.87556 432.445;1.25511 1413.32;13.8374 0 0 Exp 4,1(0.5);Linear,1(0.5) 1.5621200540203524 3.1243549585342407 1.5487829446792603 1.5755720138549805 0.01894273247582728 1.5621774792671204 -312.25937120000003 978.6249312 -205.71603719999996 639.4161472 -657.9142479999999 2085.0716479999996 UP 1.0 0.0 0.0 GO:0071372 7 cellular response to follicle-stimulating hormone stimulus 17 19 4 4 4 3 3 3 66 16 2462 0.99859 0.013512 0.013512 15.79 29200;29739;25283 inhba;gclm;gclc INHBA_33300;GCLM_8700;GCLC_8699 142.66713333333334 145.958 91.8104 49.293756199475595 146.0399594435901 48.39715425937018 70.02916666666665 69.2223 44.1594 26.282490627855932 71.4687163777436 25.739309646698107 321.189 280.185 186.93 158.78275452013045 330.6418878093108 158.76429083898614 0.0 91.8104 0.5 118.88419999999999 91.8104;190.233;145.958 44.1594;69.2223;96.7058 186.93;496.452;280.185 2 1 2 29739;25283 GCLM_8700;GCLC_8699 168.09550000000002 168.09550000000002 31.30715273703435 82.96405 82.96405 19.433769220740455 388.3185 388.3185 152.9238622468713 190.233;145.958 69.2223;96.7058 496.452;280.185 1 29200 INHBA_33300 91.8104 91.8104 44.1594 44.1594 186.93 186.93 91.8104 44.1594 186.93 0 Hill,2(0.67);Poly 2,1(0.34) 1.974948667032209 5.961641788482666 1.7603585720062256 2.2924909591674805 0.27459732039430657 1.90879225730896 86.88599704750877 198.4482696191579 40.287728710292484 99.77060462304085 141.50939851285958 500.8686014871405 UP 0.6666666666666666 0.3333333333333333 0.0 GO:1901576 4 organic substance biosynthetic process 397 444 35 35 33 25 23 23 46 421 2057 0.99966 8.8642E-4 0.0010765 5.18 83472;287877;293820;58835;361042;29685;24539;116682;64194;29200;84029;24426;29739;25283;499709;24890;25315;24296;81508;25612;25748;360887;296925 ugdh;pycr1;psat1;phgdh;pck2;mcm6;lpl;kynu;insig1;inhba;hao2;gstp1;gclm;gclc;gar1;esr1;ephx1;cyp1a1;bhmt;asns;alas2;coq8a;aass UGDH_10131;PYCR1_9631;PSAT1_9583;PHGDH_9470;PCK2_9440;MCM6_9210;LPL_32544;KYNU_8979;INSIG1_8906;INHBA_33300;HAO2_8778;GSTP1_8762;GCLM_8700;GCLC_8699;GAR1_8683;ESR1_33192;EPHX1_8567;CYP1A1_8415;BHMT_8143;ASNS_8091;ALAS2_8019;ADCK3_7987;AASS_7936 499709(-0.07184) 158.11281652173912 91.8104 1.87441 240.23014730627727 109.28942321192484 187.7589252693903 97.97118334782608 63.0271 0.496857 156.25859166414327 65.44573352974669 115.7621713544689 385.36101304347824 161.456 9.53 739.2338990685125 269.2877410980757 612.0820134727911 21.5 832.741 59.3662;132.668;27.1579;122.826;6.67763;1.87441;900.118;100.381;37.6554;91.8104;140.856;122.514;190.233;145.958;765.364;12.5403;27.5708;83.0393;5.5396;6.05608;125.506;525.072;5.81076 25.4417;90.3184;10.0144;67.6778;1.48195;0.496857;487.466;72.7231;13.2791;44.1594;93.5219;84.8469;69.2223;96.7058;587.034;3.74981;12.6303;63.0271;1.97501;2.7438;85.7907;336.426;2.60489 135.068;239.858;103.876;246.456;37.9425;9.53;3428.38;161.456;101.065;186.93;282.925;216.573;496.452;280.185;1362.21;51.2968;61.9858;119.986;37.8319;14.3351;236.762;1038.12;14.0792 14 9 14 83472;287877;293820;58835;361042;29685;64194;24426;29739;25283;499709;25315;24296;25612 UGDH_10131;PYCR1_9631;PSAT1_9583;PHGDH_9470;PCK2_9440;MCM6_9210;INSIG1_8906;GSTP1_8762;GCLM_8700;GCLC_8699;GAR1_8683;EPHX1_8567;CYP1A1_8415;ASNS_8091 123.49719428571429 71.20275 194.31726086206447 80.35145764285714 44.2344 150.2219306482591 244.6801714285714 127.52700000000002 347.16718806699646 59.3662;132.668;27.1579;122.826;6.67763;1.87441;37.6554;122.514;190.233;145.958;765.364;27.5708;83.0393;6.05608 25.4417;90.3184;10.0144;67.6778;1.48195;0.496857;13.2791;84.8469;69.2223;96.7058;587.034;12.6303;63.0271;2.7438 135.068;239.858;103.876;246.456;37.9425;9.53;101.065;216.573;496.452;280.185;1362.21;61.9858;119.986;14.3351 9 24539;116682;29200;84029;24890;81508;25748;360887;296925 LPL_32544;KYNU_8979;INHBA_33300;HAO2_8778;ESR1_33192;BHMT_8143;ALAS2_8019;ADCK3_7987;AASS_7936 211.95934 100.381 303.292667545324 125.37964555555557 72.7231 170.54870785745769 604.1978777777778 186.93 1103.8207158844316 900.118;100.381;91.8104;140.856;12.5403;5.5396;125.506;525.072;5.81076 487.466;72.7231;44.1594;93.5219;3.74981;1.97501;85.7907;336.426;2.60489 3428.38;161.456;186.93;282.925;51.2968;37.8319;236.762;1038.12;14.0792 0 Exp 2,3(0.14);Exp 4,2(0.09);Exp 5,1(0.05);Hill,10(0.44);Poly 2,7(0.31) 2.1431649550512795 53.714773416519165 1.528982162475586 6.292444229125977 1.2306000780712643 1.8211764097213745 59.933577649089344 256.29205539438897 34.1101327306503 161.83223396500185 83.24480334529892 687.4772227416577 UP 0.6086956521739131 0.391304347826087 0.0 GO:0071704 3 organic substance metabolic process 1263 1393 84 82 72 56 46 46 23 1347 1131 0.98505 0.027488 0.049409 3.3 83472;360243;266730;171497;299270;94195;291317;293656;287877;293820;58835;361042;680308;313108;24552;29685;312538;24539;116682;293502;64194;29200;84029;24426;300850;116686;24404;29739;25283;499709;84586;24890;25315;171142;298452;25426;24296;290277;310395;81508;25612;24207;25748;26760;360887;296925 ugdh;top2a;slc17a3;sgk2;serpina6;s100a9;rpp38;rgd1307603;pycr1;psat1;phgdh;pck2;mthfd2;mms22l;me1;mcm6;mcm2;lpl;kynu;kif22;insig1;inhba;hao2;gstp1;gsta4;gsr;gpx1;gclm;gclc;gar1;fgl2;esr1;ephx1;ehhadh;dph2;cyp1b1;cyp1a1;cryl1;noct;bhmt;asns;apoc3;alas2;akr7a3;coq8a;aass UGDH_10131;TOP2A_10059;SLC17A3_9840;SGK2_32380;SERPINA6_32325;S100A9_9775;RPP38_9741;RGD1307603_9684;PYCR1_9631;PSAT1_9583;PHGDH_9470;PCK2_9440;MTHFD2_9261;MMS22L_33129;ME1_9215;MCM6_9210;MCM2_9206;LPL_32544;KYNU_8979;KIF22_8963;INSIG1_8906;INHBA_33300;HAO2_8778;GSTP1_8762;GSTA4_8757;GSR_8755;GPX1_33050;GCLM_8700;GCLC_8699;GAR1_8683;FGL2_32918;ESR1_33192;EPHX1_8567;EHHADH_8534;DPH2_8490;CYP1B1_32710;CYP1A1_8415;CRYL1_8388;CCRN4L_8232;BHMT_8143;ASNS_8091;APOC3_32553;ALAS2_8019;AKR7A3_8015;ADCK3_7987;AASS_7936 499709(-0.07184) 193.93165991304357 87.42484999999999 4.48597E-12 279.44333603266784 154.69059265350583 244.41699402183806 132.0702178478262 53.59325 4.48597E-12 205.83273807670614 104.75627623415903 177.96074743204952 393.2773386956523 139.243 4.48599E-12 636.85575254582 311.3193746094116 554.4127507015742 59.3662;4.48597E-12;93.3839;156.37;25.7745;963.318;916.962;32.0155;132.668;27.1579;122.826;6.67763;622.58;4.13516;13.1175;1.87441;3.76863;900.118;100.381;0.961856;37.6554;91.8104;140.856;122.514;339.498;69.5519;8.00432;190.233;145.958;765.364;146.406;12.5403;27.5708;166.899;734.134;229.313;83.0393;32.8011;665.276;5.5396;6.05608;2.87451;125.506;57.1167;525.072;5.81076 25.4417;4.48597E-12;68.9252;100.616;8.17372;802.143;769.912;12.3892;90.3184;10.0144;67.6778;1.48195;414.266;1.24709;6.20444;0.496857;0.956203;487.466;72.7231;0.281971;13.2791;44.1594;93.5219;84.8469;260.156;41.1016;2.69961;69.2223;96.7058;587.034;95.6156;3.74981;12.6303;105.26;463.289;185.32;63.0271;15.4462;433.686;1.97501;2.7438;1.13737;85.7907;33.0666;336.426;2.60489 135.068;4.48599E-12;143.418;343.205;103.274;1158.68;1051.72;78.5761;239.858;103.876;246.456;37.9425;1250.29;20.8956;28.4614;9.53;22.9217;3428.38;161.456;4.47267;101.065;186.93;282.925;216.573;486.944;124.212;25.2254;496.452;280.185;1362.21;325.091;51.2968;61.9858;384.658;1764.85;299.27;119.986;74.622;1425.48;37.8319;14.3351;8.23841;236.762;102.949;1038.12;14.0792 29 17 29 83472;360243;266730;171497;94195;287877;293820;58835;361042;680308;313108;24552;29685;312538;293502;64194;24426;300850;116686;29739;25283;499709;25315;25426;24296;290277;310395;25612;26760 UGDH_10131;TOP2A_10059;SLC17A3_9840;SGK2_32380;S100A9_9775;PYCR1_9631;PSAT1_9583;PHGDH_9470;PCK2_9440;MTHFD2_9261;MMS22L_33129;ME1_9215;MCM6_9210;MCM2_9206;KIF22_8963;INSIG1_8906;GSTP1_8762;GSTA4_8757;GSR_8755;GCLM_8700;GCLC_8699;GAR1_8683;EPHX1_8567;CYP1B1_32710;CYP1A1_8415;CRYL1_8388;CCRN4L_8232;ASNS_8091;AKR7A3_8015 171.7293953793105 69.5519 254.79178096906375 120.2874727931036 41.1016 197.05388086752052 307.28771620689673 124.212 426.89984428318365 59.3662;4.48597E-12;93.3839;156.37;963.318;132.668;27.1579;122.826;6.67763;622.58;4.13516;13.1175;1.87441;3.76863;0.961856;37.6554;122.514;339.498;69.5519;190.233;145.958;765.364;27.5708;229.313;83.0393;32.8011;665.276;6.05608;57.1167 25.4417;4.48597E-12;68.9252;100.616;802.143;90.3184;10.0144;67.6778;1.48195;414.266;1.24709;6.20444;0.496857;0.956203;0.281971;13.2791;84.8469;260.156;41.1016;69.2223;96.7058;587.034;12.6303;185.32;63.0271;15.4462;433.686;2.7438;33.0666 135.068;4.48599E-12;143.418;343.205;1158.68;239.858;103.876;246.456;37.9425;1250.29;20.8956;28.4614;9.53;22.9217;4.47267;101.065;216.573;486.944;124.212;496.452;280.185;1362.21;61.9858;299.27;119.986;74.622;1425.48;14.3351;102.949 17 299270;291317;293656;24539;116682;29200;84029;24404;84586;24890;171142;298452;81508;24207;25748;360887;296925 SERPINA6_32325;RPP38_9741;RGD1307603_9684;LPL_32544;KYNU_8979;INHBA_33300;HAO2_8778;GPX1_33050;FGL2_32918;ESR1_33192;EHHADH_8534;DPH2_8490;BHMT_8143;APOC3_32553;ALAS2_8019;ADCK3_7987;AASS_7936 231.80611117647058 100.381 321.8672893492169 152.17019470588238 72.7231 224.77480596334925 539.965518235294 186.93 886.2946201048683 25.7745;916.962;32.0155;900.118;100.381;91.8104;140.856;8.00432;146.406;12.5403;166.899;734.134;5.5396;2.87451;125.506;525.072;5.81076 8.17372;769.912;12.3892;487.466;72.7231;44.1594;93.5219;2.69961;95.6156;3.74981;105.26;463.289;1.97501;1.13737;85.7907;336.426;2.60489 103.274;1051.72;78.5761;3428.38;161.456;186.93;282.925;25.2254;325.091;51.2968;384.658;1764.85;37.8319;8.23841;236.762;1038.12;14.0792 0 Exp 2,3(0.07);Exp 4,8(0.18);Exp 5,1(0.03);Hill,16(0.35);Linear,5(0.11);Poly 2,13(0.29) 2.0272356782162504 100.32620537281036 1.5039241313934326 6.292444229125977 1.0560761287205602 1.7625030279159546 113.17638259879423 274.68693722729284 72.58739002403983 191.5530456716125 209.23479312569685 577.3198842656077 UP 0.6304347826086957 0.3695652173913043 0.0 GO:0070314 4 G1 to G0 transition 2 2 1 1 1 1 1 1 68 1 2477 0.99928 0.053458 0.053458 50.0 58835 phgdh PHGDH_9470 122.826 122.826 122.826 122.826 67.6778 67.6778 67.6778 67.6778 246.456 246.456 246.456 246.45600000000002 0.0 122.826 0.0 122.826 122.826 67.6778 246.456 1 0 1 58835 PHGDH_9470 122.826 122.826 67.6778 67.6778 246.456 246.456 122.826 67.6778 246.456 0 0 Exp 4,1(1) 1.7978414297103882 1.7978414297103882 1.7978414297103882 1.7978414297103882 0.0 1.7978414297103882 122.826 122.826 67.6778 67.6778 246.456 246.456 UP 1.0 0.0 0.0 GO:0043648 7 dicarboxylic acid metabolic process 32 33 6 6 6 5 5 5 64 28 2450 0.9998 0.0016598 0.0016598 15.15 361042;24552;116682;29739;25283 pck2;me1;kynu;gclm;gclc PCK2_9440;ME1_9215;KYNU_8979;GCLM_8700;GCLC_8699 91.273426 100.381 6.67763 80.82565386957832 76.92113187395465 82.47469041148128 49.26751800000001 69.2223 1.48195 42.82708677535304 40.72732679534355 43.86444752302033 200.89938 161.456 28.4614 194.6041768817463 174.33132709573826 192.61095184711257 0.5 9.897565 2.5 123.1695 6.67763;13.1175;100.381;190.233;145.958 1.48195;6.20444;72.7231;69.2223;96.7058 37.9425;28.4614;161.456;496.452;280.185 4 1 4 361042;24552;29739;25283 PCK2_9440;ME1_9215;GCLM_8700;GCLC_8699 88.9965325 79.53775 93.14408267763207 43.4036225 37.713370000000005 47.07770894296676 210.760225 159.06375 223.26248927888116 6.67763;13.1175;190.233;145.958 1.48195;6.20444;69.2223;96.7058 37.9425;28.4614;496.452;280.185 1 116682 KYNU_8979 100.381 100.381 72.7231 72.7231 161.456 161.456 100.381 72.7231 161.456 0 Exp 4,1(0.2);Hill,2(0.4);Poly 2,2(0.4) 1.9991703898528168 10.330946445465088 1.528982162475586 3.1753315925598145 0.6420497847235342 1.90879225730896 20.426616699727575 162.12023530027244 11.727921295275102 86.80711470472491 30.321298060512703 371.4774619394873 UP 0.8 0.2 0.0 GO:0071345 6 cellular response to cytokine stimulus 172 189 8 8 7 6 5 5 64 184 2294 0.59404 0.5903 1.0 2.65 361042;312538;170496;29739;25426 pck2;mcm2;lcn2;gclm;cyp1b1 PCK2_9440;MCM2_9206;LCN2_32481;GCLM_8700;CYP1B1_32710 280.52365199999997 190.233 3.76863 400.4265159774663 220.33274447558335 334.11157968662263 161.7822906 69.2223 0.956203 230.70469258304843 134.7478865505172 194.88748376853457 988.2312400000001 299.27 22.9217 1742.0318112179705 683.5041019846042 1437.2760686974793 6.67763;3.76863;972.626;190.233;229.313 1.48195;0.956203;551.931;69.2223;185.32 37.9425;22.9217;4084.57;496.452;299.27 5 0 5 361042;312538;170496;29739;25426 PCK2_9440;MCM2_9206;LCN2_32481;GCLM_8700;CYP1B1_32710 280.52365199999997 190.233 400.4265159774663 161.7822906 69.2223 230.70469258304843 988.2312400000001 299.27 1742.0318112179705 6.67763;3.76863;972.626;190.233;229.313 1.48195;0.956203;551.931;69.2223;185.32 37.9425;22.9217;4084.57;496.452;299.27 0 0 Hill,3(0.6);Linear,2(0.4) 1.924097559884155 10.007212281227112 1.5280487537384033 3.1843981742858887 0.6848640119427118 1.856990933418274 -70.46566460985593 631.512968609856 -40.43928853480398 364.00386973480397 -538.7269671493815 2515.1894471493815 UP 1.0 0.0 0.0 GO:0010942 6 positive regulation of cell death 222 238 14 14 12 6 5 5 64 233 2245 0.36333 0.78778 0.67739 2.1 360243;94195;29200;360504;25426 top2a;s100a9;inhba;hba-a2;cyp1b1 TOP2A_10059;S100A9_9775;INHBA_33300;HBA2_32600;CYP1B1_32710 283.0982800000009 131.05 4.48597E-12 389.0520827750333 189.32025882879944 247.11455360149048 224.0434400000009 88.5948 4.48597E-12 330.3780679044956 146.2591589445013 209.45409673936857 379.8086000000009 254.163 4.48599E-12 450.10295144533234 268.37717138805 290.05667710306955 4.48597E-12;963.318;91.8104;131.05;229.313 4.48597E-12;802.143;44.1594;88.5948;185.32 4.48599E-12;1158.68;186.93;254.163;299.27 3 2 3 360243;94195;25426 TOP2A_10059;S100A9_9775;CYP1B1_32710 397.5436666666681 229.313 503.2112480721506 329.1543333333348 185.32 419.9697425962159 485.9833333333349 299.27 601.4825327749188 4.48597E-12;963.318;229.313 4.48597E-12;802.143;185.32 4.48599E-12;1158.68;299.27 2 29200;360504 INHBA_33300;HBA2_32600 111.43020000000001 111.43020000000001 27.746587251047607 66.3771 66.3771 31.420572664736735 220.5465 220.5465 47.540910219515155 91.8104;131.05 44.1594;88.5948 186.93;254.163 0 Hill,2(0.4);Linear,1(0.2);Poly 2,2(0.4) 2.116983961198831 10.883510828018188 1.7056305408477783 3.1843981742858887 0.608813405826077 1.948032259941101 -57.920906318156085 624.1174663181579 -65.54570469892053 513.6325846989224 -14.724032151578797 774.3412321515805 UP 0.6 0.4 0.0 GO:1902533 7 positive regulation of intracellular signal transduction 254 269 11 11 9 5 4 4 65 265 2213 0.13044 0.94444 0.23542 1.49 94195;24404;25317;24890 s100a9;gpx1;fgf1;esr1 S100A9_9775;GPX1_33050;FGF1_8633;ESR1_33192 414.50615500000004 343.35115 8.00432 481.46854847061957 322.8024696310433 418.840015287683 311.553605 220.68590500000002 2.69961 385.87785681836516 221.5613508392403 305.9283050304452 675.05055 604.9884000000001 25.2254 745.9354406100191 636.7265921392221 790.1656910990729 963.318;8.00432;674.162;12.5403 802.143;2.69961;437.622;3.74981 1158.68;25.2254;1465.0;51.2968 2 2 2 94195;25317 S100A9_9775;FGF1_8633 818.74 818.74 204.46416842077682 619.8825 619.8825 257.7552709849015 1311.8400000000001 1311.8400000000001 216.60094921306222 963.318;674.162 802.143;437.622 1158.68;1465.0 2 24404;24890 GPX1_33050;ESR1_33192 10.272310000000001 10.272310000000001 3.20742221732655 3.22471 3.22471 0.7426035416021101 38.2611 38.2611 18.435263735026957 8.00432;12.5403 2.69961;3.74981 25.2254;51.2968 0 Hill,2(0.5);Linear,1(0.25);Poly 2,1(0.25) 1.696252933776819 6.79254412651062 1.5704141855239868 1.7846373319625854 0.09126693110777115 1.718746304512024 -57.33302250120721 886.3453325012073 -66.6066946819978 689.7139046819977 -55.96618179781865 1406.0672817978189 CONFLICT 0.5 0.5 0.0 GO:0044092 4 negative regulation of molecular function 276 297 21 21 14 14 8 8 61 289 2189 0.58606 0.5644 1.0 2.69 299270;312538;288001;24426;24404;24890;25426;24207 serpina6;mcm2;kng1;gstp1;gpx1;esr1;cyp1b1;apoc3 SERPINA6_32325;MCM2_9206;KNG1L1_32433;GSTP1_8762;GPX1_33050;ESR1_33192;CYP1B1_32710;APOC3_32553 288001(0.1788) 51.083102499999995 10.272310000000001 2.87451 82.49796857665989 58.147668084375 96.04750040564358 36.017340375 3.22471 0.956203 66.8222057635398 43.127827446958335 79.16334901027278 92.57958875 38.2611 8.23841 108.6386580395402 95.79348252229165 119.75028764452219 25.7745;3.76863;3.87556;122.514;8.00432;12.5403;229.313;2.87451 8.17372;0.956203;1.25511;84.8469;2.69961;3.74981;185.32;1.13737 103.274;22.9217;13.8374;216.573;25.2254;51.2968;299.27;8.23841 4 4 4 312538;288001;24426;25426 MCM2_9206;KNG1L1_32433;GSTP1_8762;CYP1B1_32710 89.8677975 63.194779999999994 108.50264296686736 68.09455325 43.051005 87.55477473298447 138.15052500000002 119.74735000000001 142.4090411075873 3.76863;3.87556;122.514;229.313 0.956203;1.25511;84.8469;185.32 22.9217;13.8374;216.573;299.27 4 299270;24404;24890;24207 SERPINA6_32325;GPX1_33050;ESR1_33192;APOC3_32553 12.2984075 10.272310000000001 9.813470548150892 3.9401275 3.22471 3.0195948667812478 47.0086525 38.2611 41.4801933910032 25.7745;8.00432;12.5403;2.87451 8.17372;2.69961;3.74981;1.13737 103.274;25.2254;51.2968;8.23841 0 Exp 4,2(0.25);Hill,4(0.5);Linear,1(0.13);Poly 2,1(0.13) 2.1160382904878787 18.860636472702026 1.5235437154769897 5.5128583908081055 1.387115373547409 1.7582497000694275 -6.085073054377496 108.25127805437748 -10.288085757656951 82.32276650765695 17.296839587209988 167.86233791279 CONFLICT 0.5 0.5 0.0 GO:0051726 5 regulation of cell cycle 252 268 17 16 16 4 4 4 65 264 2214 0.13261 0.94332 0.23551 1.49 360243;29200;24296;25612 top2a;inhba;cyp1a1;asns TOP2A_10059;INHBA_33300;CYP1A1_8415;ASNS_8091 45.22644500000112 44.547689999999996 4.48597E-12 48.92043093386066 53.34486246293279 47.094606650536896 27.48257500000112 23.4516 4.48597E-12 31.138554166216803 35.47148917695214 32.61652169123447 80.31277500000112 67.16055 4.48599E-12 88.96514837321931 87.9949471188859 80.9154556046465 4.48597E-12;91.8104;83.0393;6.05608 4.48597E-12;44.1594;63.0271;2.7438 4.48599E-12;186.93;119.986;14.3351 3 1 3 360243;24296;25612 TOP2A_10059;CYP1A1_8415;ASNS_8091 29.698460000001493 6.05608 46.293659772917785 21.92363333333483 2.7438 35.62307312154911 44.7737000000015 14.3351 65.52893503231834 4.48597E-12;83.0393;6.05608 4.48597E-12;63.0271;2.7438 4.48599E-12;119.986;14.3351 1 29200 INHBA_33300 91.8104 91.8104 44.1594 44.1594 186.93 186.93 91.8104 44.1594 186.93 0 Hill,3(0.75);Poly 2,1(0.25) 3.0742800409508857 13.870335459709167 1.75295889377594 6.292444229125977 2.0252427593615194 2.9124661684036255 -2.7155773151823297 93.16846731518457 -3.0332080828913384 57.99835808289359 -6.8730704057537935 167.49862040575604 UP 0.75 0.25 0.0 GO:0050866 6 negative regulation of cell activation 64 66 3 3 2 3 2 2 67 64 2414 0.73551 0.53985 0.69922 3.03 25283;84586 gclc;fgl2 GCLC_8699;FGL2_32918 146.18200000000002 146.18200000000002 145.958 0.3167838379621317 146.03858986175115 0.24334967536974741 96.16069999999999 96.16069999999999 95.6156 0.7708878128534553 96.50968601053324 0.5921870894438774 302.63800000000003 302.63800000000003 280.185 31.75333711596289 288.2630543120474 24.392545806800378 145.958;146.406 96.7058;95.6156 280.185;325.091 1 1 1 25283 GCLC_8699 145.958 145.958 96.7058 96.7058 280.185 280.185 145.958 96.7058 280.185 1 84586 FGL2_32918 146.406 146.406 95.6156 95.6156 325.091 325.091 146.406 95.6156 325.091 0 Poly 2,2(1) 1.7091101070839285 3.41971218585968 1.6593536138534546 1.7603585720062256 0.07142129084328783 1.70985609292984 145.74296 146.62104000000002 95.092304 97.22909599999998 258.63012000000003 346.64588000000003 CONFLICT 0.5 0.5 0.0 GO:0051252 6 regulation of RNA metabolic process 500 535 25 25 20 17 13 13 56 522 1956 0.39285 0.71865 0.76498 2.43 360243;363465;259241;316351;64194;29200;25283;25317;24890;24309;25426;289185;310395 top2a;pir;nr1d2;npas2;insig1;inhba;gclc;fgf1;esr1;dbp;cyp1b1;creg1;noct TOP2A_10059;PIR_9487;NR1D2_9358;NPAS2_9350;INSIG1_8906;INHBA_33300;GCLC_8699;FGF1_8633;ESR1_33192;DBP_8439;CYP1B1_32710;CREG1_8380;CCRN4L_8232 171.93107000000035 91.8104 4.48597E-12 230.337499063554 192.76541066452813 249.776802234059 103.40743923076957 36.7323 4.48597E-12 155.87660828317516 122.13781010860733 168.18172641509145 385.24187692307726 280.185 4.48599E-12 483.90077416906104 416.836328014306 527.2099249929097 4.48597E-12;152.213;9.46041;53.0014;37.6554;91.8104;145.958;674.162;12.5403;66.0377;229.313;97.6763;665.276 4.48597E-12;56.4566;2.2133;14.3825;13.2791;44.1594;96.7058;437.622;3.74981;19.9899;185.32;36.7323;433.686 4.48599E-12;371.778;49.4216;215.15;101.065;186.93;280.185;1465.0;51.2968;280.428;299.27;282.14;1425.48 10 3 10 360243;363465;259241;64194;25283;25317;24309;25426;289185;310395 TOP2A_10059;PIR_9487;NR1D2_9358;INSIG1_8906;GCLC_8699;FGF1_8633;DBP_8439;CYP1B1_32710;CREG1_8380;CCRN4L_8232 207.77518100000043 121.81715 253.38757161393835 128.20050000000043 46.59445 171.28787739219052 455.47676000000047 281.284 535.4968576900834 4.48597E-12;152.213;9.46041;37.6554;145.958;674.162;66.0377;229.313;97.6763;665.276 4.48597E-12;56.4566;2.2133;13.2791;96.7058;437.622;19.9899;185.32;36.7323;433.686 4.48599E-12;371.778;49.4216;101.065;280.185;1465.0;280.428;299.27;282.14;1425.48 3 316351;29200;24890 NPAS2_9350;INHBA_33300;ESR1_33192 52.450700000000005 53.0014 39.637919236130436 20.76390333333333 14.3825 20.94696809490656 151.1256 186.93 87.59813971814702 53.0014;91.8104;12.5403 14.3825;44.1594;3.74981 215.15;186.93;51.2968 0 Exp 4,2(0.16);Exp 5,1(0.08);Hill,6(0.47);Linear,3(0.24);Poly 2,1(0.08) 1.999275413239708 26.53781819343567 1.5704141855239868 3.1843981742858887 0.4614589278716786 1.9026079177856445 46.71817918999005 297.14396081001064 18.671949733201146 188.142928728338 122.19041962566115 648.2933342204933 UP 0.7692307692307693 0.23076923076923078 0.0 GO:0051253 7 negative regulation of RNA metabolic process 238 250 11 11 7 7 4 4 65 246 2232 0.17683 0.9196 0.30995 1.6 259241;25283;24890;310395 nr1d2;gclc;esr1;noct NR1D2_9358;GCLC_8699;ESR1_33192;CCRN4L_8232 208.3086775 79.24915 9.46041 311.2194466579608 186.96236396759073 308.97290792794723 134.0887275 50.227805 2.2133 204.56080656803007 119.72936504378157 203.22614541643892 451.59585000000004 165.7409 49.4216 658.2338677382353 410.7178346764524 651.3350526891884 9.46041;145.958;12.5403;665.276 2.2133;96.7058;3.74981;433.686 49.4216;280.185;51.2968;1425.48 3 1 3 259241;25283;310395 NR1D2_9358;GCLC_8699;CCRN4L_8232 273.5648033333333 145.958 346.02910891206255 177.53503333333333 96.7058 226.80872212563457 585.0288666666667 280.185 736.9406470916456 9.46041;145.958;665.276 2.2133;96.7058;433.686 49.4216;280.185;1425.48 1 24890 ESR1_33192 12.5403 12.5403 3.74981 3.74981 51.2968 51.2968 12.5403 3.74981 51.2968 0 Hill,2(0.5);Linear,1(0.25);Poly 2,1(0.25) 1.8480680650341257 7.426736235618591 1.7318620681762695 2.177004337310791 0.2139310278011909 1.7589349150657654 -96.68638022480167 513.3037352248016 -66.3808629366695 334.5583179366695 -193.4733403834706 1096.6650403834706 UP 0.75 0.25 0.0 GO:0000724 8 double-strand break repair via homologous recombination 15 15 4 4 4 3 3 3 66 12 2466 0.99946 0.0068558 0.0068558 20.0 313108;29685;312538 mms22l;mcm6;mcm2 MMS22L_33129;MCM6_9210;MCM2_9206 3.2594 3.76863 1.87441 1.2133565161567326 3.1603619533892413 1.2950941501192987 0.9000499999999999 0.956203 0.496857 0.37825554606509143 0.8906028625306955 0.4140907673983961 17.782433333333334 20.8956 9.53 7.2182589482044275 16.74922991243108 7.268802295927947 0.0 1.87441 0.5 2.82152 4.13516;1.87441;3.76863 1.24709;0.496857;0.956203 20.8956;9.53;22.9217 3 0 3 313108;29685;312538 MMS22L_33129;MCM6_9210;MCM2_9206 3.2594 3.76863 1.2133565161567326 0.9000499999999999 0.956203 0.37825554606509143 17.782433333333334 20.8956 7.2182589482044275 4.13516;1.87441;3.76863 1.24709;0.496857;0.956203 20.8956;9.53;22.9217 0 0 Exp 4,1(0.34);Hill,2(0.67) 1.6640888398982288 5.005148768424988 1.5280487537384033 1.8211764097213745 0.14696047640898105 1.65592360496521 1.8863578459968924 4.632442154003107 0.47201355496742786 1.3280864450325722 9.614204389553876 25.95066227711279 UP 1.0 0.0 0.0 GO:0006805 4 xenobiotic metabolic process 43 62 8 8 6 7 5 5 64 57 2421 0.9941 0.024697 0.024697 8.06 58835;24426;300850;25426;24296 phgdh;gstp1;gsta4;cyp1b1;cyp1a1 PHGDH_9470;GSTP1_8762;GSTA4_8757;CYP1B1_32710;CYP1A1_8415 179.43806 122.826 83.0393 104.69561703656936 181.6403292201691 104.24436262531478 132.20556000000002 84.8469 63.0271 87.1561711072314 137.0839005355465 86.1882900758676 273.8458 246.456 119.986 135.79437176186653 265.33467450673345 138.6825032960189 2.5 176.0695 122.826;122.514;339.498;229.313;83.0393 67.6778;84.8469;260.156;185.32;63.0271 246.456;216.573;486.944;299.27;119.986 5 0 5 58835;24426;300850;25426;24296 PHGDH_9470;GSTP1_8762;GSTA4_8757;CYP1B1_32710;CYP1A1_8415 179.43806 122.826 104.69561703656936 132.20556000000002 84.8469 87.1561711072314 273.8458 246.456 135.79437176186653 122.826;122.514;339.498;229.313;83.0393 67.6778;84.8469;260.156;185.32;63.0271 246.456;216.573;486.944;299.27;119.986 0 0 Exp 4,1(0.2);Linear,2(0.4);Poly 2,2(0.4) 3.223596701492857 18.540326833724976 1.7527846097946167 6.292444229125977 2.1025340437557087 3.1843981742858887 87.66830547709873 271.20781452290123 55.809807684285985 208.60131231571404 154.81678508120677 392.8748149187932 UP 1.0 0.0 0.0 GO:0070848 5 response to growth factor 153 159 10 10 9 6 5 5 64 154 2324 0.74105 0.43354 0.61689 3.14 59107;25663;24426;29739;25283 ltbp1;il1r1;gstp1;gclm;gclc LTBP1_33264;IL1R1_8893;GSTP1_8762;GCLM_8700;GCLC_8699 260.94416 145.958 76.6218 287.1762379313929 196.95249632579794 210.86462174840042 143.2647 84.8469 27.5215 166.84120397202545 101.57670297301846 124.21512859745806 677.9105999999999 280.185 185.143 865.6993631372845 493.09966965838333 631.5648941592176 769.394;76.6218;122.514;190.233;145.958 438.027;27.5215;84.8469;69.2223;96.7058 2211.2;185.143;216.573;496.452;280.185 4 1 4 25663;24426;29739;25283 IL1R1_8893;GSTP1_8762;GCLM_8700;GCLC_8699 133.8317 134.236 47.36108383008137 69.57412500000001 77.03460000000001 30.2100010742993 294.58825 248.37900000000002 140.2629306632725 76.6218;122.514;190.233;145.958 27.5215;84.8469;69.2223;96.7058 185.143;216.573;496.452;280.185 1 59107 LTBP1_33264 769.394 769.394 438.027 438.027 2211.2 2211.2 769.394 438.027 2211.2 0 Exp 2,1(0.2);Hill,2(0.4);Poly 2,2(0.4) 2.164287329170884 12.389218926429749 1.5140434503555298 5.5128583908081055 1.702538416538384 1.7603585720062256 9.223088901398768 512.6652310986012 -2.97806322350786 289.5074632235079 -80.90834862887152 1436.7295486288713 UP 0.8 0.2 0.0 GO:0007346 6 regulation of mitotic cell cycle 146 155 9 9 9 3 3 3 66 152 2326 0.3856 0.80262 0.79714 1.94 360243;24296;25612 top2a;cyp1a1;asns TOP2A_10059;CYP1A1_8415;ASNS_8091 29.698460000001493 6.05608 4.48597E-12 46.293659772917785 44.575625765374184 49.42320755922548 21.92363333333483 2.7438 4.48597E-12 35.62307312154911 33.490850109028784 37.92054171000825 44.7737000000015 14.3351 4.48599E-12 65.52893503231834 65.44008497601526 70.24709385661143 4.48597E-12;83.0393;6.05608 4.48597E-12;63.0271;2.7438 4.48599E-12;119.986;14.3351 3 0 3 360243;24296;25612 TOP2A_10059;CYP1A1_8415;ASNS_8091 29.698460000001493 6.05608 46.293659772917785 21.92363333333483 2.7438 35.62307312154911 44.7737000000015 14.3351 65.52893503231834 4.48597E-12;83.0393;6.05608 4.48597E-12;63.0271;2.7438 4.48599E-12;119.986;14.3351 0 0 Hill,2(0.67);Poly 2,1(0.34) 3.3901742703927242 11.577844500541687 1.75295889377594 6.292444229125977 2.287323791408066 3.5324413776397705 -22.687747586065896 82.08466758606887 -18.38766874459786 62.234935411267514 -29.37927063001076 118.92667063001375 UP 1.0 0.0 0.0 GO:0071705 5 nitrogen compound transport 239 254 6 5 3 5 2 2 67 252 2226 0.025193 0.99431 0.041729 0.79 266730;24207 slc17a3;apoc3 SLC17A3_9840;APOC3_32553 48.129205 48.129205 2.87451 63.999803430057895 41.55266113929916 63.32039940479375 35.031285000000004 35.031285000000004 1.13737 47.93323427492088 30.105722721691283 47.42438845720053 75.828205 75.828205 8.23841 95.58640476701724 66.0058594653924 94.57168621041713 93.3839;2.87451 68.9252;1.13737 143.418;8.23841 1 1 1 266730 SLC17A3_9840 93.3839 93.3839 68.9252 68.9252 143.418 143.418 93.3839 68.9252 143.418 1 24207 APOC3_32553 2.87451 2.87451 1.13737 1.13737 8.23841 8.23841 2.87451 1.13737 8.23841 0 Exp 4,1(0.5);Poly 2,1(0.5) 1.513912274794703 3.0278854370117188 1.504341721534729 1.5235437154769897 0.013577860128875578 1.5139427185058594 -40.56999719999999 136.8284072 -31.40078839999999 101.4633584 -56.647793200000024 208.30420320000002 CONFLICT 0.5 0.5 0.0 GO:0042127 5 regulation of cell population proliferation 436 466 20 20 18 8 6 6 63 460 2018 0.020147 0.9925 0.038949 1.29 29200;24426;24404;25317;24890;25426 inhba;gstp1;gpx1;fgf1;esr1;cyp1b1 INHBA_33300;GSTP1_8762;GPX1_33050;FGF1_8633;ESR1_33192;CYP1B1_32710 189.72400333333334 107.1622 8.00432 250.90549120134952 231.01324400816395 274.44048016089874 126.39961999999998 64.50315 2.69961 166.83268965301247 157.30685648139345 181.38629787038124 374.0492 201.75150000000002 25.2254 544.3206923313793 448.8401724718316 601.6350398645767 91.8104;122.514;8.00432;674.162;12.5403;229.313 44.1594;84.8469;2.69961;437.622;3.74981;185.32 186.93;216.573;25.2254;1465.0;51.2968;299.27 3 3 3 24426;25317;25426 GSTP1_8762;FGF1_8633;CYP1B1_32710 341.9963333333333 229.313 292.5782445506387 235.92963333333333 185.32 181.751393487377 660.281 299.27 698.1326522753395 122.514;674.162;229.313 84.8469;437.622;185.32 216.573;1465.0;299.27 3 29200;24404;24890 INHBA_33300;GPX1_33050;ESR1_33192 37.45167333333333 12.5403 47.13063920907644 16.869606666666666 3.74981 23.639486989823475 87.8174 51.2968 86.81825892955926 91.8104;8.00432;12.5403 44.1594;2.69961;3.74981 186.93;25.2254;51.2968 0 Hill,3(0.5);Linear,2(0.34);Poly 2,1(0.17) 2.40878600732828 16.076661109924316 1.5704141855239868 5.5128583908081055 1.5074140840562067 2.038564145565033 -11.042202854522344 390.49020952118906 -7.094334274887842 259.89357427488784 -61.498064532448154 809.5964645324482 CONFLICT 0.5 0.5 0.0 GO:0031668 4 cellular response to extracellular stimulus 98 103 9 9 7 7 5 5 64 98 2380 0.94226 0.14421 0.1999 4.85 59107;24539;170496;24426;25612 ltbp1;lpl;lcn2;gstp1;asns LTBP1_33264;LPL_32544;LCN2_32481;GSTP1_8762;ASNS_8091 554.1416160000001 769.394 6.05608 454.9347701653251 617.2171660568358 464.7304694580449 313.00294 438.027 2.7438 250.73437402998417 345.70760781139546 257.8080564764572 1991.01162 2211.2 14.3351 1840.74576964378 2350.204852099534 1908.7888212738303 769.394;900.118;972.626;122.514;6.05608 438.027;487.466;551.931;84.8469;2.7438 2211.2;3428.38;4084.57;216.573;14.3351 3 2 3 170496;24426;25612 LCN2_32481;GSTP1_8762;ASNS_8091 367.06536 122.514 527.653653754609 213.1739 84.8469 296.2305003839241 1438.4927 216.573 2293.800089421606 972.626;122.514;6.05608 551.931;84.8469;2.7438 4084.57;216.573;14.3351 2 59107;24539 LTBP1_33264;LPL_32544 834.7560000000001 834.7560000000001 92.43582686382874 462.74649999999997 462.74649999999997 34.958652155082945 2819.79 2819.79 860.6762319246413 769.394;900.118 438.027;487.466 2211.2;3428.38 0 Exp 2,2(0.4);Hill,1(0.2);Linear,1(0.2);Poly 2,1(0.2) 2.4771732522479333 14.119990468025208 1.5140434503555298 5.5128583908081055 1.7057338082830913 1.856990933418274 155.37370800417915 952.9095239958208 93.22457098625418 532.7813090137457 377.52681327428513 3604.4964267257146 UP 0.6 0.4 0.0 GO:0035094 5 response to nicotine 34 36 4 4 4 3 3 3 66 33 2445 0.98488 0.07193 0.07193 8.33 300850;116686;24404 gsta4;gsr;gpx1 GSTA4_8757;GSR_8755;GPX1_33050 139.01807333333332 69.5519 8.00432 176.3269035007651 132.63124908092973 172.67967136199127 101.31907000000001 41.1016 2.69961 138.8904458840085 96.15270107924951 136.04155193210158 212.12713333333332 124.212 25.2254 243.090146649866 203.52192505180622 238.04731075123792 0.5 38.77811 339.498;69.5519;8.00432 260.156;41.1016;2.69961 486.944;124.212;25.2254 2 1 2 300850;116686 GSTA4_8757;GSR_8755 204.52495 204.52495 190.8807178648619 150.6288 150.6288 154.89485168875044 305.57800000000003 305.57800000000003 256.4902569533587 339.498;69.5519 260.156;41.1016 486.944;124.212 1 24404 GPX1_33050 8.00432 8.00432 2.69961 2.69961 25.2254 25.2254 8.00432 2.69961 25.2254 0 Exp 4,1(0.34);Hill,1(0.34);Linear,1(0.34) 1.7831682814771903 5.3500072956085205 1.7527846097946167 1.8125853538513184 0.029921610993667105 1.7846373319625854 -60.51460166168485 338.5507483283516 -55.85026518523895 258.488405185239 -62.955263413732325 487.2095300803989 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0090036 7 regulation of protein kinase C signaling 3 3 1 1 1 1 1 1 68 2 2476 0.99787 0.07912 0.07912 33.33 192247 sez6 SEZ6_9819 10.6392 10.6392 10.6392 10.6392 3.96047 3.96047 3.96047 3.96047 29.4997 29.4997 29.4997 29.4997 0.0 10.6392 0.0 10.6392 10.6392 3.96047 29.4997 0 1 0 1 192247 SEZ6_9819 10.6392 10.6392 3.96047 3.96047 29.4997 29.4997 10.6392 3.96047 29.4997 0 Hill,1(1) 3.7477371692657475 3.747737169265747 3.747737169265747 3.747737169265747 0.0 3.747737169265747 10.6392 10.6392 3.96047 3.96047 29.4997 29.4997 DOWN 0.0 1.0 0.0 GO:0042542 5 response to hydrogen peroxide 74 80 7 7 6 4 4 4 65 76 2402 0.93672 0.16928 0.16928 5.0 170496;360504;24404;25426 lcn2;hba-a2;gpx1;cyp1b1 LCN2_32481;HBA2_32600;GPX1_33050;CYP1B1_32710 335.24833 180.1815 8.00432 434.4568211811568 275.26003723140656 364.87464425625853 207.13635250000002 136.9574 2.69961 241.66490817809074 180.34983502442645 204.30596309177596 1165.8071 276.7165 25.2254 1949.5371238264502 831.2764864501504 1644.432130024765 3.0 972.626 972.626;131.05;8.00432;229.313 551.931;88.5948;2.69961;185.32 4084.57;254.163;25.2254;299.27 2 2 2 170496;25426 LCN2_32481;CYP1B1_32710 600.9694999999999 600.9694999999999 525.6016628441164 368.6255 368.6255 259.23312415758147 2191.92 2191.92 2676.6112988254386 972.626;229.313 551.931;185.32 4084.57;299.27 2 360504;24404 HBA2_32600;GPX1_33050 69.52716000000001 69.52716000000001 87.00643472370994 45.647205 45.647205 60.73707132030694 139.6942 139.6942 161.88332942857338 131.05;8.00432 88.5948;2.69961 254.163;25.2254 0 Hill,1(0.25);Linear,2(0.5);Poly 2,1(0.25) 2.129343944352604 8.77405869960785 1.7846373319625854 3.1843981742858887 0.6639630099028352 1.9025115966796875 -90.5193547575335 761.0160147575335 -29.69525751452892 443.96796251452895 -744.7392813499212 3076.353481349921 CONFLICT 0.5 0.5 0.0 GO:0031667 5 response to nutrient levels 239 256 30 30 26 19 16 16 53 240 2238 0.99969 9.5687E-4 0.0015597 6.25 361042;24614;59107;24539;170496;116682;24426;116686;24404;29739;25283;25426;24296;25612;24207;114628 pck2;orm1;ltbp1;lpl;lcn2;kynu;gstp1;gsr;gpx1;gclm;gclc;cyp1b1;cyp1a1;asns;apoc3;abcg5 PCK2_9440;ORM1_9400;LTBP1_33264;LPL_32544;LCN2_32481;KYNU_8979;GSTP1_8762;GSR_8755;GPX1_33050;GCLM_8700;GCLC_8699;CYP1B1_32710;CYP1A1_8415;ASNS_8091;APOC3_32553;ABCG5_7947 302.16210875 134.236 2.87451 345.72894583164776 233.78074360735576 301.35910526729384 182.358095625 78.785 1.13737 200.89206154755595 147.0595845041465 180.5270024440003 873.080338125 248.37900000000002 8.23841 1284.4175704084535 615.6834236812155 1086.8492012833926 11.5 613.9265 6.67763;662.49;769.394;900.118;972.626;100.381;122.514;69.5519;8.00432;190.233;145.958;229.313;83.0393;6.05608;2.87451;565.363 1.48195;432.445;438.027;487.466;551.931;72.7231;84.8469;41.1016;2.69961;69.2223;96.7058;185.32;63.0271;2.7438;1.13737;386.851 37.9425;1413.32;2211.2;3428.38;4084.57;161.456;216.573;124.212;25.2254;496.452;280.185;299.27;119.986;14.3351;8.23841;1047.94 10 6 10 361042;24614;170496;24426;116686;29739;25283;25426;24296;25612 PCK2_9440;ORM1_9400;LCN2_32481;GSTP1_8762;GSR_8755;GCLM_8700;GCLC_8699;CYP1B1_32710;CYP1A1_8415;ASNS_8091 248.84589100000002 134.236 316.67583925375743 152.882545 77.03460000000001 188.34468992632225 708.68456 248.37900000000002 1253.960501804508 6.67763;662.49;972.626;122.514;69.5519;190.233;145.958;229.313;83.0393;6.05608 1.48195;432.445;551.931;84.8469;41.1016;69.2223;96.7058;185.32;63.0271;2.7438 37.9425;1413.32;4084.57;216.573;124.212;496.452;280.185;299.27;119.986;14.3351 6 59107;24539;116682;24404;24207;114628 LTBP1_33264;LPL_32544;KYNU_8979;GPX1_33050;APOC3_32553;ABCG5_7947 391.02247166666666 332.872 403.6265848396381 231.4840133333333 229.78705 229.31750491004306 1147.0733016666666 604.698 1405.2389393808928 769.394;900.118;100.381;8.00432;2.87451;565.363 438.027;487.466;72.7231;2.69961;1.13737;386.851 2211.2;3428.38;161.456;25.2254;8.23841;1047.94 0 Exp 2,2(0.13);Exp 4,2(0.13);Hill,4(0.25);Linear,4(0.25);Poly 2,4(0.25) 2.1777330506632224 39.20557355880737 1.5140434503555298 6.292444229125977 1.4711491718986212 1.798611342906952 132.7549252924926 471.56929220750743 83.92098546669762 280.79520578330244 243.7157286248579 1502.444947625142 UP 0.625 0.375 0.0 GO:0046889 7 positive regulation of lipid biosynthetic process 46 50 6 6 5 3 2 2 67 48 2430 0.84811 0.39522 0.39522 4.0 25317;24207 fgf1;apoc3 FGF1_8633;APOC3_32553 338.518255 338.518255 2.87451 474.6719363046967 300.2032771224927 471.5690533270205 219.379685 219.379685 1.13737 308.64124175670116 194.46651561809782 306.62368482525244 736.619205 736.619205 8.23841 1030.085998861097 653.4718368080911 1023.3524297011184 674.162;2.87451 437.622;1.13737 1465.0;8.23841 1 1 1 25317 FGF1_8633 674.162 674.162 437.622 437.622 1465.0 1465.0 674.162 437.622 1465.0 1 24207 APOC3_32553 2.87451 2.87451 1.13737 1.13737 8.23841 8.23841 2.87451 1.13737 8.23841 0 Exp 4,1(0.5);Linear,1(0.5) 1.5468014297417059 3.0939579010009766 1.5235437154769897 1.5704141855239868 0.03314242720763259 1.5469789505004883 -319.3434852 996.3799951999999 -208.37525240000002 647.1346224 -691.0071532 2164.2455632 CONFLICT 0.5 0.5 0.0 GO:0009408 4 response to heat 54 59 6 6 6 3 3 3 66 56 2422 0.92636 0.21343 0.21343 5.08 25663;25283;25317 il1r1;gclc;fgf1 IL1R1_8893;GCLC_8699;FGF1_8633 298.9139333333333 145.958 76.6218 326.81831468021096 364.3031164926693 343.64852487264614 187.2831 96.7058 27.5215 219.542229380887 231.10101950482056 230.2344261342385 643.4426666666667 280.185 185.143 713.074739705687 786.1213879856238 750.9796886748476 1.5 410.06 76.6218;145.958;674.162 27.5215;96.7058;437.622 185.143;280.185;1465.0 3 0 3 25663;25283;25317 IL1R1_8893;GCLC_8699;FGF1_8633 298.9139333333333 145.958 326.81831468021096 187.2831 96.7058 219.542229380887 643.4426666666667 280.185 713.074739705687 76.6218;145.958;674.162 27.5215;96.7058;437.622 185.143;280.185;1465.0 0 0 Hill,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 1.6727780375676478 5.02393901348114 1.5704141855239868 1.7603585720062256 0.09631696638970189 1.6931662559509277 -70.91580490183708 668.7436715685038 -61.15231985382954 435.71851985382955 -163.47736345927876 1450.362696792612 UP 1.0 0.0 0.0 GO:0030154 4 cell differentiation 405 432 27 27 23 14 11 11 58 421 2057 0.48732 0.64111 1.0 2.55 360243;363465;58835;361042;259241;29200;24404;25317;24890;24296;25748 top2a;pir;phgdh;pck2;nr1d2;inhba;gpx1;fgf1;esr1;cyp1a1;alas2 TOP2A_10059;PIR_9487;PHGDH_9470;PCK2_9440;NR1D2_9358;INHBA_33300;GPX1_33050;FGF1_8633;ESR1_33192;CYP1A1_8415;ALAS2_8019 116.93085090909132 83.0393 4.48597E-12 193.33396296114708 117.42712476093163 212.99095044340518 69.53438818181858 44.1594 4.48597E-12 126.2561921782542 72.41362524659318 139.099779472196 253.70893636363678 119.986 4.48599E-12 418.29170360046146 254.99034566439562 460.03692366560557 4.48597E-12;152.213;122.826;6.67763;9.46041;91.8104;8.00432;674.162;12.5403;83.0393;125.506 4.48597E-12;56.4566;67.6778;1.48195;2.2133;44.1594;2.69961;437.622;3.74981;63.0271;85.7907 4.48599E-12;371.778;246.456;37.9425;49.4216;186.93;25.2254;1465.0;51.2968;119.986;236.762 7 4 7 360243;363465;58835;361042;259241;25317;24296 TOP2A_10059;PIR_9487;PHGDH_9470;PCK2_9440;NR1D2_9358;FGF1_8633;CYP1A1_8415 149.76833428571493 83.0393 239.0136549970355 89.78267857142922 56.4566 156.43617004350287 327.22630000000066 119.986 518.6398637119623 4.48597E-12;152.213;122.826;6.67763;9.46041;674.162;83.0393 4.48597E-12;56.4566;67.6778;1.48195;2.2133;437.622;63.0271 4.48599E-12;371.778;246.456;37.9425;49.4216;1465.0;119.986 4 29200;24404;24890;25748 INHBA_33300;GPX1_33050;ESR1_33192;ALAS2_8019 59.465255 52.17535 58.474403625439116 34.09988 23.954605 39.49784179749825 125.05355 119.1134 102.81567741836194 91.8104;8.00432;12.5403;125.506 44.1594;2.69961;3.74981;85.7907 186.93;25.2254;51.2968;236.762 0 Exp 4,1(0.1);Hill,7(0.64);Linear,1(0.1);Poly 2,2(0.19) 2.060637384049281 24.889448881149292 1.528982162475586 6.292444229125977 1.3604661467937489 1.7846373319625854 2.67777998416382 231.1839218340188 -5.078253377451944 144.1470297410891 6.514336166171688 500.9035365611018 UP 0.6363636363636364 0.36363636363636365 0.0 GO:0010468 6 regulation of gene expression 723 775 43 43 36 29 23 23 46 752 1726 0.74961 0.33996 0.59711 2.97 308843;360243;94195;58835;24614;259241;316351;59107;24539;170496;64194;29200;25663;24426;24404;25283;25317;24890;298452;24309;25426;289185;310395 tsku;top2a;s100a9;phgdh;orm1;nr1d2;npas2;ltbp1;lpl;lcn2;insig1;inhba;il1r1;gstp1;gpx1;gclc;fgf1;esr1;dph2;dbp;cyp1b1;creg1;noct TSKU_10094;TOP2A_10059;S100A9_9775;PHGDH_9470;ORM1_9400;NR1D2_9358;NPAS2_9350;LTBP1_33264;LPL_32544;LCN2_32481;INSIG1_8906;INHBA_33300;IL1R1_8893;GSTP1_8762;GPX1_33050;GCLC_8699;FGF1_8633;ESR1_33192;DPH2_8490;DBP_8439;CYP1B1_32710;CREG1_8380;CCRN4L_8232 326.401596956522 122.514 4.48597E-12 359.6692672957939 277.674574851651 330.8223948303732 204.1292747826089 67.6778 4.48597E-12 239.6173526367138 172.65579775183315 212.66757688205442 850.289686956522 280.185 4.48599E-12 1126.7602640548434 719.4607840604843 1038.9657006668508 92.2997;4.48597E-12;963.318;122.826;662.49;9.46041;53.0014;769.394;900.118;972.626;37.6554;91.8104;76.6218;122.514;8.00432;145.958;674.162;12.5403;734.134;66.0377;229.313;97.6763;665.276 49.0864;4.48597E-12;802.143;67.6778;432.445;2.2133;14.3825;438.027;487.466;551.931;13.2791;44.1594;27.5215;84.8469;2.69961;96.7058;437.622;3.74981;463.289;19.9899;185.32;36.7323;433.686 185.899;4.48599E-12;1158.68;246.456;1413.32;49.4216;215.15;2211.2;3428.38;4084.57;101.065;186.93;185.143;216.573;25.2254;280.185;1465.0;51.2968;1764.85;280.428;299.27;282.14;1425.48 16 7 16 308843;360243;94195;58835;24614;259241;170496;64194;25663;24426;25283;25317;24309;25426;289185;310395 TSKU_10094;TOP2A_10059;S100A9_9775;PHGDH_9470;ORM1_9400;NR1D2_9358;LCN2_32481;INSIG1_8906;IL1R1_8893;GSTP1_8762;GCLC_8699;FGF1_8633;DBP_8439;CYP1B1_32710;CREG1_8380;CCRN4L_8232 308.6396443750003 122.66999999999999 348.2921072137593 202.57500000000027 76.26235 247.4741959218238 729.6019125000003 280.3065 1039.2396675812893 92.2997;4.48597E-12;963.318;122.826;662.49;9.46041;972.626;37.6554;76.6218;122.514;145.958;674.162;66.0377;229.313;97.6763;665.276 49.0864;4.48597E-12;802.143;67.6778;432.445;2.2133;551.931;13.2791;27.5215;84.8469;96.7058;437.622;19.9899;185.32;36.7323;433.686 185.899;4.48599E-12;1158.68;246.456;1413.32;49.4216;4084.57;101.065;185.143;216.573;280.185;1465.0;280.428;299.27;282.14;1425.48 7 316351;59107;24539;29200;24404;24890;298452 NPAS2_9350;LTBP1_33264;LPL_32544;INHBA_33300;GPX1_33050;ESR1_33192;DPH2_8490 367.00034571428574 91.8104 410.2371511390364 207.68190285714286 44.1594 239.57716219388556 1126.147457142857 215.15 1351.8464995571883 53.0014;769.394;900.118;91.8104;8.00432;12.5403;734.134 14.3825;438.027;487.466;44.1594;2.69961;3.74981;463.289 215.15;2211.2;3428.38;186.93;25.2254;51.2968;1764.85 0 Exp 2,2(0.09);Exp 4,4(0.18);Exp 5,1(0.05);Hill,7(0.31);Linear,6(0.27);Poly 2,3(0.14) 1.994567136658969 48.47179687023163 1.5140434503555298 5.5128583908081055 0.88693834474951 1.7603585720062256 179.40899296846305 473.3942009445809 106.20047789202326 302.0580716731945 389.79600472182847 1310.7833691912153 UP 0.6956521739130435 0.30434782608695654 0.0 GO:0055129 9 L-proline biosynthetic process 1 1 1 1 1 1 1 1 68 0 2478 1.0 0.027091 0.027091 100.0 287877 pycr1 PYCR1_9631 132.668 132.668 132.668 132.668 90.3184 90.3184 90.3184 90.3184 239.858 239.858 239.858 239.85800000000003 0.0 132.668 0.0 132.668 132.668 90.3184 239.858 1 0 1 287877 PYCR1_9631 132.668 132.668 90.3184 90.3184 239.858 239.858 132.668 90.3184 239.858 0 0 Poly 2,1(1) 1.7646474838256836 1.7646474838256836 1.7646474838256836 1.7646474838256836 0.0 1.7646474838256836 132.668 132.668 90.3184 90.3184 239.858 239.858 UP 1.0 0.0 0.0 GO:1903706 5 regulation of hemopoiesis 119 128 5 5 3 4 2 2 67 126 2352 0.31606 0.87099 0.5803 1.56 29200;84586 inhba;fgl2 INHBA_33300;FGL2_32918 119.10820000000001 119.10820000000001 91.8104 38.604918982948256 103.12281531753555 31.293365475564578 69.8875 69.8875 44.1594 36.385027954091235 54.82131973459716 29.493909263452547 256.0105 256.0105 186.93 97.69457999551484 215.55748303317537 79.19177859515203 91.8104;146.406 44.1594;95.6156 186.93;325.091 0 2 0 2 29200;84586 INHBA_33300;FGL2_32918 119.10820000000001 119.10820000000001 38.604918982948256 69.8875 69.8875 36.385027954091235 256.0105 256.0105 97.69457999551484 91.8104;146.406 44.1594;95.6156 186.93;325.091 0 Hill,1(0.5);Poly 2,1(0.5) 1.9503982049368613 3.951844573020935 1.6593536138534546 2.2924909591674805 0.44769571029399646 1.9759222865104675 65.604512 172.61188800000002 19.460424000000003 120.314576 120.61271999999997 391.40828 DOWN 0.0 1.0 0.0 GO:0006066 4 alcohol metabolic process 93 100 15 15 13 8 6 6 63 94 2384 0.98296 0.051265 0.051265 6.0 361042;64194;25315;25426;24296;24207 pck2;insig1;ephx1;cyp1b1;cyp1a1;apoc3 PCK2_9440;INSIG1_8906;EPHX1_8567;CYP1B1_32710;CYP1A1_8415;APOC3_32553 64.52177333333333 32.6131 2.87451 85.71178871191374 67.08059328314859 89.24422576355762 46.14597 12.954699999999999 1.13737 71.94242588651566 49.11459236364639 74.5060763983945 104.74795166666667 81.52539999999999 8.23841 103.62456384279172 105.59171294453941 108.40053550739853 4.0 83.0393 6.67763;37.6554;27.5708;229.313;83.0393;2.87451 1.48195;13.2791;12.6303;185.32;63.0271;1.13737 37.9425;101.065;61.9858;299.27;119.986;8.23841 5 1 5 361042;64194;25315;25426;24296 PCK2_9440;INSIG1_8906;EPHX1_8567;CYP1B1_32710;CYP1A1_8415 76.851226 37.6554 89.68290183919049 55.14769 13.2791 76.5631019542573 124.04986 101.065 103.09381795092276 6.67763;37.6554;27.5708;229.313;83.0393 1.48195;13.2791;12.6303;185.32;63.0271 37.9425;101.065;61.9858;299.27;119.986 1 24207 APOC3_32553 2.87451 2.87451 1.13737 1.13737 8.23841 8.23841 2.87451 1.13737 8.23841 0 Exp 4,1(0.17);Exp 5,1(0.17);Hill,2(0.34);Linear,1(0.17);Poly 2,1(0.17) 2.5633913345521515 17.586793899536133 1.5235437154769897 6.292444229125977 1.8036552169853441 2.528712809085846 -4.06194144657438 133.10548811324105 -11.419959864786641 103.71189986478663 21.831031630455698 187.66487170287763 UP 0.8333333333333334 0.16666666666666666 0.0 GO:0010605 6 negative regulation of macromolecule metabolic process 531 562 25 25 19 14 9 9 60 553 1925 0.040413 0.98122 0.076624 1.6 299270;24614;259241;288001;24426;24404;25283;24890;310395 serpina6;orm1;nr1d2;kng1;gstp1;gpx1;gclc;esr1;noct SERPINA6_32325;ORM1_9400;NR1D2_9358;KNG1L1_32433;GSTP1_8762;GPX1_33050;GCLC_8699;ESR1_33192;CCRN4L_8232 288001(0.1788) 183.98812111111113 25.7745 3.87556 277.0658965575049 148.3717896598985 262.7867654659633 118.41947222222221 8.17372 1.25511 182.18442677256053 94.137264463621 173.03359141669802 397.6236888888889 103.274 13.8374 586.1420411705093 329.6725564213198 553.5635375088378 25.7745;662.49;9.46041;3.87556;122.514;8.00432;145.958;12.5403;665.276 8.17372;432.445;2.2133;1.25511;84.8469;2.69961;96.7058;3.74981;433.686 103.274;1413.32;49.4216;13.8374;216.573;25.2254;280.185;51.2968;1425.48 6 3 6 24614;259241;288001;24426;25283;310395 ORM1_9400;NR1D2_9358;KNG1L1_32433;GSTP1_8762;GCLC_8699;CCRN4L_8232 268.2623283333333 134.236 311.80603994847655 175.19201833333332 90.77635000000001 203.71364563328106 566.4695 248.37900000000002 668.1589560812336 662.49;9.46041;3.87556;122.514;145.958;665.276 432.445;2.2133;1.25511;84.8469;96.7058;433.686 1413.32;49.4216;13.8374;216.573;280.185;1425.48 3 299270;24404;24890 SERPINA6_32325;GPX1_33050;ESR1_33192 15.439706666666666 12.5403 9.23307876995173 4.8743799999999995 3.74981 2.9051614992457826 59.932066666666664 51.2968 39.73439144234292 25.7745;8.00432;12.5403 8.17372;2.69961;3.74981 103.274;25.2254;51.2968 0 Exp 4,1(0.12);Hill,4(0.45);Linear,2(0.23);Poly 2,2(0.23) 2.0222521677928658 19.868302941322327 1.5487829446792603 5.5128583908081055 1.255104456224725 1.7603585720062256 2.9717353602079584 365.0045068620143 -0.6076866025173189 237.44663104696178 14.67755532415623 780.5698224536216 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0006579 6 amino-acid betaine catabolic process 3 3 1 1 1 1 1 1 68 2 2476 0.99787 0.07912 0.07912 33.33 81508 bhmt BHMT_8143 5.5396 5.5396 5.5396 5.5396 1.97501 1.97501 1.97501 1.9750100000000002 37.8319 37.8319 37.8319 37.8319 0.0 5.5396 0.0 5.5396 5.5396 1.97501 37.8319 0 1 0 1 81508 BHMT_8143 5.5396 5.5396 1.97501 1.97501 37.8319 37.8319 5.5396 1.97501 37.8319 0 Exp 4,1(1) 1.6724973917007446 1.6724973917007446 1.6724973917007446 1.6724973917007446 0.0 1.6724973917007446 5.5396 5.5396 1.97501 1.97501 37.8319 37.8319 DOWN 0.0 1.0 0.0 GO:0050778 6 positive regulation of immune response 121 142 3 3 3 2 2 2 67 140 2338 0.24913 0.90619 0.43295 1.41 25663;117517 il1r1;c7 IL1R1_8893;C7_8179 90.2399 90.2399 76.6218 19.258901713752998 94.8713391788154 18.1109038285191 30.12645 30.12645 27.5215 3.683955619303825 31.01237883653778 3.4643598540252616 239.462 239.462 185.143 76.81866649454429 257.9355862384675 72.23960648411514 76.6218;103.858 27.5215;32.7314 185.143;293.781 1 1 1 25663 IL1R1_8893 76.6218 76.6218 27.5215 27.5215 185.143 185.143 76.6218 27.5215 185.143 1 117517 C7_8179 103.858 103.858 32.7314 32.7314 293.781 293.781 103.858 32.7314 293.781 0 Hill,2(1) 1.8080875197830126 3.623975157737732 1.6931662559509277 1.9308089017868042 0.1680387263696613 1.811987578868866 63.548424 116.93137600000001 25.020747999999998 35.232152 132.99676 345.92724 CONFLICT 0.5 0.5 0.0 GO:0001889 6 liver development 91 101 9 9 7 7 5 5 64 96 2382 0.94663 0.13587 0.19485 4.95 25315;24309;24296;25612;25748 ephx1;dbp;cyp1a1;asns;alas2 EPHX1_8567;DBP_8439;CYP1A1_8415;ASNS_8091;ALAS2_8019 61.641976 66.0377 6.05608 46.921259290068924 59.35630454410954 37.054038758641 36.83636 19.9899 2.7438 35.75794131795062 33.86434288822489 30.34445353859725 142.69938 119.986 14.3351 113.27501628307984 145.7253444518581 107.72583160216072 27.5708;66.0377;83.0393;6.05608;125.506 12.6303;19.9899;63.0271;2.7438;85.7907 61.9858;280.428;119.986;14.3351;236.762 4 1 4 25315;24309;24296;25612 EPHX1_8567;DBP_8439;CYP1A1_8415;ASNS_8091 45.67597 46.804249999999996 35.15750911551613 24.597775 16.3101 26.57606826418272 119.183725 90.9859 115.85219988437497 27.5708;66.0377;83.0393;6.05608 12.6303;19.9899;63.0271;2.7438 61.9858;280.428;119.986;14.3351 1 25748 ALAS2_8019 125.506 125.506 85.7907 85.7907 236.762 236.762 125.506 85.7907 236.762 0 Exp 4,1(0.2);Hill,2(0.4);Poly 2,2(0.4) 2.9668827605370263 16.577014446258545 1.7586312294006348 6.292444229125977 1.8289214480589349 3.0908896923065186 20.513678857904843 102.77027314209516 5.493142491224692 68.17957750877531 43.409450467946115 241.98930953205394 UP 0.8 0.2 0.0 GO:0010035 4 response to inorganic substance 271 293 22 22 17 16 12 12 57 281 2197 0.95284 0.09126 0.12535 4.1 94195;24567;170496;25663;360504;300850;116686;24404;25283;25426;24296;25748 s100a9;mt1;lcn2;il1r1;hba-a2;gsta4;gsr;gpx1;gclc;cyp1b1;cyp1a1;alas2 S100A9_9775;MT1A_9255;LCN2_32481;IL1R1_8893;HBA2_32600;GSTA4_8757;GSR_8755;GPX1_33050;GCLC_8699;CYP1B1_32710;CYP1A1_8415;ALAS2_8019 330.23502666666667 138.50400000000002 8.00432 366.15102054288946 229.43114782194465 283.5652374983935 228.7672591666667 92.6503 2.69961 260.2259962667059 157.90185756480318 190.06786442252928 686.9696166666668 267.174 25.2254 1125.3614350919925 513.3232919814551 1012.2997056714188 963.318;818.334;972.626;76.6218;131.05;339.498;69.5519;8.00432;145.958;229.313;83.0393;125.506 802.143;540.216;551.931;27.5215;88.5948;260.156;41.1016;2.69961;96.7058;185.32;63.0271;85.7907 1158.68;988.495;4084.57;185.143;254.163;486.944;124.212;25.2254;280.185;299.27;119.986;236.762 8 4 8 94195;170496;25663;300850;116686;25283;25426;24296 S100A9_9775;LCN2_32481;IL1R1_8893;GSTA4_8757;GSR_8755;GCLC_8699;CYP1B1_32710;CYP1A1_8415 359.99075 187.63549999999998 386.1878074619431 253.48825 141.0129 280.765974336116 842.37375 289.72749999999996 1353.2388115521485 963.318;972.626;76.6218;339.498;69.5519;145.958;229.313;83.0393 802.143;551.931;27.5215;260.156;41.1016;96.7058;185.32;63.0271 1158.68;4084.57;185.143;486.944;124.212;280.185;299.27;119.986 4 24567;360504;24404;25748 MT1A_9255;HBA2_32600;GPX1_33050;ALAS2_8019 270.72357999999997 128.27800000000002 369.45700523813633 179.3252775 87.19275 243.87119328440173 376.16134999999997 245.4625 421.2775475099008 818.334;131.05;8.00432;125.506 540.216;88.5948;2.69961;85.7907 988.495;254.163;25.2254;236.762 0 Exp 4,1(0.09);Hill,2(0.17);Linear,3(0.25);Poly 2,6(0.5) 2.1272740177938436 27.886833667755127 1.6931662559509277 6.292444229125977 1.3192582912776774 1.798611342906952 123.06558419766316 537.4044691356703 81.53054115183983 376.00397718149344 50.23644373040099 1323.7027896029326 UP 0.6666666666666666 0.3333333333333333 0.0 GO:2001014 6 regulation of skeletal muscle cell differentiation 9 9 1 1 1 1 1 1 68 8 2470 0.97697 0.21931 0.21931 11.11 259241 nr1d2 NR1D2_9358 9.46041 9.46041 9.46041 9.46041 2.2133 2.2133 2.2133 2.2133 49.4216 49.4216 49.4216 49.4216 0.0 9.46041 0.0 9.46041 9.46041 2.2133 49.4216 1 0 1 259241 NR1D2_9358 9.46041 9.46041 2.2133 2.2133 49.4216 49.4216 9.46041 2.2133 49.4216 0 0 Hill,1(1) 2.177004337310791 2.177004337310791 2.177004337310791 2.177004337310791 0.0 2.177004337310791 9.46041 9.46041 2.2133 2.2133 49.4216 49.4216 UP 1.0 0.0 0.0 GO:0071107 5 response to parathyroid hormone 7 8 2 2 2 2 2 2 67 6 2472 0.99903 0.018227 0.018227 25.0 360243;59107 top2a;ltbp1 TOP2A_10059;LTBP1_33264 384.6970000000022 384.6970000000022 4.48597E-12 544.0437148042395 182.45848312206587 462.7987988316541 219.01350000000224 219.01350000000224 4.48597E-12 309.73186204279665 103.87622204814471 263.47797026729097 1105.6000000000022 1105.6000000000022 4.48599E-12 1563.5545145596907 524.3765845321213 1330.060676294015 0.0 4.48597E-12 0.0 4.48597E-12 4.48597E-12;769.394 4.48597E-12;438.027 4.48599E-12;2211.2 1 1 1 360243 TOP2A_10059 4.48597E-12 4.48597E-12 4.48597E-12 4.48597E-12 4.48599E-12 4.48599E-12 4.48597E-12 4.48597E-12 4.48599E-12 1 59107 LTBP1_33264 769.394 769.394 438.027 438.027 2211.2 2211.2 769.394 438.027 2211.2 0 Exp 2,1(0.5);Hill,1(0.5) 1.6291273528683805 3.2670023441314697 1.5140434503555298 1.75295889377594 0.16893873017276295 1.6335011720657349 -369.3091199999932 1138.7031199999979 -210.25295999999332 648.2799599999978 -1061.375999999993 3272.5759999999973 CONFLICT 0.5 0.5 0.0 GO:0071375 6 cellular response to peptide hormone stimulus 102 109 11 11 8 9 6 6 63 103 2375 0.97384 0.072123 0.072123 5.5 361042;24614;64194;24426;25283;25426 pck2;orm1;insig1;gstp1;gclc;cyp1b1 PCK2_9440;ORM1_9400;INSIG1_8906;GSTP1_8762;GCLC_8699;CYP1B1_32710 200.768005 134.236 6.67763 239.75263874689549 145.36564029173897 180.77843637749137 135.67979166666666 90.77635000000001 1.48195 159.76713309726887 103.03677683145604 127.2149011689807 391.3925833333333 248.37900000000002 37.9425 510.8753851293305 258.38777310825515 358.1488847541719 4.5 445.9015 6.67763;662.49;37.6554;122.514;145.958;229.313 1.48195;432.445;13.2791;84.8469;96.7058;185.32 37.9425;1413.32;101.065;216.573;280.185;299.27 6 0 6 361042;24614;64194;24426;25283;25426 PCK2_9440;ORM1_9400;INSIG1_8906;GSTP1_8762;GCLC_8699;CYP1B1_32710 200.768005 134.236 239.75263874689549 135.67979166666666 90.77635000000001 159.76713309726887 391.3925833333333 248.37900000000002 510.8753851293305 6.67763;662.49;37.6554;122.514;145.958;229.313 1.48195;432.445;13.2791;84.8469;96.7058;185.32 37.9425;1413.32;101.065;216.573;280.185;299.27 0 0 Exp 5,1(0.17);Hill,1(0.17);Linear,2(0.34);Poly 2,2(0.34) 2.2891980498947433 15.50191617012024 1.528982162475586 5.5128583908081055 1.5609659055370053 1.8634472489356995 8.925939390864414 392.6100706091356 7.839460106492609 263.5201232268407 -17.392861800135506 800.1780284668022 UP 1.0 0.0 0.0 GO:0000096 6 sulfur amino acid metabolic process 12 14 3 3 3 3 3 3 66 11 2467 0.9996 0.0055922 0.0055922 21.43 29739;25283;81508 gclm;gclc;bhmt GCLM_8700;GCLC_8699;BHMT_8143 113.91019999999999 145.958 5.5396 96.42722185420465 108.6476748108784 98.55419275183446 55.96770333333333 69.2223 1.97501 48.736473950246264 53.10110218255706 49.527345904078835 271.48963333333336 280.185 37.8319 229.4336637943598 260.73977317286653 233.06750648167053 0.0 5.5396 0.5 75.7488 190.233;145.958;5.5396 69.2223;96.7058;1.97501 496.452;280.185;37.8319 2 1 2 29739;25283 GCLM_8700;GCLC_8699 168.09550000000002 168.09550000000002 31.30715273703435 82.96405 82.96405 19.433769220740455 388.3185 388.3185 152.9238622468713 190.233;145.958 69.2223;96.7058 496.452;280.185 1 81508 BHMT_8143 5.5396 5.5396 1.97501 1.97501 37.8319 37.8319 5.5396 1.97501 37.8319 0 Exp 4,1(0.34);Hill,1(0.34);Poly 2,1(0.34) 1.7779044532361872 5.34164822101593 1.6724973917007446 1.90879225730896 0.11943436792511328 1.7603585720062256 4.79252631032368 223.0278736896763 0.8171912784587079 111.11821538820796 11.861001729775296 531.1182649368914 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0043200 5 response to amino acid 78 82 5 5 4 5 4 4 65 78 2400 0.93107 0.18007 0.28141 4.88 24426;29739;25283;25612 gstp1;gclm;gclc;asns GSTP1_8762;GCLM_8700;GCLC_8699;ASNS_8091 116.19027 134.236 6.05608 78.60867845065368 127.25032008341742 80.32381598788538 63.3797 77.03460000000001 2.7438 41.961561619415455 64.70573130171545 41.024920566661194 251.886275 248.37900000000002 14.3351 198.57055825449677 288.5981954120417 208.4277540070538 122.514;190.233;145.958;6.05608 84.8469;69.2223;96.7058;2.7438 216.573;496.452;280.185;14.3351 4 0 4 24426;29739;25283;25612 GSTP1_8762;GCLM_8700;GCLC_8699;ASNS_8091 116.19027 134.236 78.60867845065368 63.3797 77.03460000000001 41.961561619415455 251.886275 248.37900000000002 198.57055825449677 122.514;190.233;145.958;6.05608 84.8469;69.2223;96.7058;2.7438 216.573;496.452;280.185;14.3351 0 0 Hill,2(0.5);Poly 2,2(0.5) 2.8441526442961655 12.714450597763062 1.7603585720062256 5.5128583908081055 1.7509793836996823 2.7206168174743652 39.15376511835939 193.2267748816406 22.25736961297285 104.50203038702715 57.28712791059317 446.48542208940694 UP 1.0 0.0 0.0 GO:0070887 4 cellular response to chemical stimulus 594 635 47 47 37 32 23 23 46 612 1866 0.95885 0.070529 0.11968 3.62 287877;361042;24614;24567;312538;59107;24539;170496;64194;29200;25663;24426;300850;116686;24404;29739;25283;24890;25315;25426;24296;25612;24207 pycr1;pck2;orm1;mt1;mcm2;ltbp1;lpl;lcn2;insig1;inhba;il1r1;gstp1;gsta4;gsr;gpx1;gclm;gclc;esr1;ephx1;cyp1b1;cyp1a1;asns;apoc3 PYCR1_9631;PCK2_9440;ORM1_9400;MT1A_9255;MCM2_9206;LTBP1_33264;LPL_32544;LCN2_32481;INSIG1_8906;INHBA_33300;IL1R1_8893;GSTP1_8762;GSTA4_8757;GSR_8755;GPX1_33050;GCLM_8700;GCLC_8699;ESR1_33192;EPHX1_8567;CYP1B1_32710;CYP1A1_8415;ASNS_8091;APOC3_32553 248.23117695652178 91.8104 2.87451 325.1570426038353 163.88106173919462 255.81954507649093 150.04965839130435 63.0271 0.956203 194.8637129515396 100.85740532316416 152.76840096157784 655.849074347826 186.93 8.23841 1113.6144665232262 429.8881428812086 929.6823178294939 132.668;6.67763;662.49;818.334;3.76863;769.394;900.118;972.626;37.6554;91.8104;76.6218;122.514;339.498;69.5519;8.00432;190.233;145.958;12.5403;27.5708;229.313;83.0393;6.05608;2.87451 90.3184;1.48195;432.445;540.216;0.956203;438.027;487.466;551.931;13.2791;44.1594;27.5215;84.8469;260.156;41.1016;2.69961;69.2223;96.7058;3.74981;12.6303;185.32;63.0271;2.7438;1.13737 239.858;37.9425;1413.32;988.495;22.9217;2211.2;3428.38;4084.57;101.065;186.93;185.143;216.573;486.944;124.212;25.2254;496.452;280.185;51.2968;61.9858;299.27;119.986;14.3351;8.23841 16 7 16 287877;361042;24614;312538;170496;64194;25663;24426;300850;116686;29739;25283;25315;25426;24296;25612 PYCR1_9631;PCK2_9440;ORM1_9400;MCM2_9206;LCN2_32481;INSIG1_8906;IL1R1_8893;GSTP1_8762;GSTA4_8757;GSR_8755;GCLM_8700;GCLC_8699;EPHX1_8567;CYP1B1_32710;CYP1A1_8415;ASNS_8091 194.14009625 102.77664999999999 265.7908825656305 120.8554345625 66.1247 162.52803094256043 511.54769375 200.858 1010.9632323221153 132.668;6.67763;662.49;3.76863;972.626;37.6554;76.6218;122.514;339.498;69.5519;190.233;145.958;27.5708;229.313;83.0393;6.05608 90.3184;1.48195;432.445;0.956203;551.931;13.2791;27.5215;84.8469;260.156;41.1016;69.2223;96.7058;12.6303;185.32;63.0271;2.7438 239.858;37.9425;1413.32;22.9217;4084.57;101.065;185.143;216.573;486.944;124.212;496.452;280.185;61.9858;299.27;119.986;14.3351 7 24567;59107;24539;29200;24404;24890;24207 MT1A_9255;LTBP1_33264;LPL_32544;INHBA_33300;GPX1_33050;ESR1_33192;APOC3_32553 371.8679328571429 91.8104 430.60200125764646 216.77931285714288 44.1594 256.36688630078567 985.6808014285715 186.93 1345.2155410989988 818.334;769.394;900.118;91.8104;8.00432;12.5403;2.87451 540.216;438.027;487.466;44.1594;2.69961;3.74981;1.13737 988.495;2211.2;3428.38;186.93;25.2254;51.2968;8.23841 0 Exp 2,2(0.09);Exp 4,2(0.09);Exp 5,1(0.05);Hill,9(0.4);Linear,4(0.18);Poly 2,5(0.22) 2.122948068128321 53.62211513519287 1.5140434503555298 6.292444229125977 1.2618585743686845 1.7846373319625854 115.34331373498443 381.119040178059 70.41114825423479 229.68816852837392 200.72792512158412 1110.970223574068 UP 0.6956521739130435 0.30434782608695654 0.0 GO:0009069 8 serine family amino acid metabolic process 11 13 4 4 4 4 4 4 65 9 2469 0.99999 2.9351E-4 2.9351E-4 30.77 293820;58835;29739;25283 psat1;phgdh;gclm;gclc PSAT1_9583;PHGDH_9470;GCLM_8700;GCLC_8699 121.54372500000001 134.392 27.1579 68.85879637322424 144.83732191714836 46.71814794430966 60.905075 68.45005 10.0144 36.45361778162996 73.3724903961946 23.735679257210936 281.74225 263.3205 103.876 162.25928232384734 325.32555461223507 139.99312491647441 0.0 27.1579 0.5 74.99195 27.1579;122.826;190.233;145.958 10.0144;67.6778;69.2223;96.7058 103.876;246.456;496.452;280.185 4 0 4 293820;58835;29739;25283 PSAT1_9583;PHGDH_9470;GCLM_8700;GCLC_8699 121.54372500000001 134.392 68.85879637322424 60.905075 68.45005 36.45361778162996 281.74225 263.3205 162.25928232384734 27.1579;122.826;190.233;145.958 10.0144;67.6778;69.2223;96.7058 103.876;246.456;496.452;280.185 0 0 Exp 4,1(0.25);Hill,2(0.5);Poly 2,1(0.25) 1.9461529005312073 7.841626048088074 1.7603585720062256 2.3746337890625 0.2832518623801708 1.853316843509674 54.06210455424019 189.0253454457598 25.180529574002662 96.62962042599733 122.72815332262962 440.7563466773704 UP 1.0 0.0 0.0 GO:0071363 6 cellular response to growth factor stimulus 136 141 8 8 7 5 4 4 65 137 2341 0.66573 0.53752 0.79104 2.84 59107;24426;29739;25283 ltbp1;gstp1;gclm;gclc LTBP1_33264;GSTP1_8762;GCLM_8700;GCLC_8699 307.02475 168.09550000000002 122.514 309.52240146972133 239.8492633541318 234.52064197344708 172.2005 90.77635000000001 69.2223 177.57471567253035 127.97668972759091 137.07346785221668 801.1025 388.3185 216.573 947.6667249676965 602.8833401308781 718.326058096358 769.394;122.514;190.233;145.958 438.027;84.8469;69.2223;96.7058 2211.2;216.573;496.452;280.185 3 1 3 24426;29739;25283 GSTP1_8762;GCLM_8700;GCLC_8699 152.90166666666667 145.958 34.38933875975705 83.59166666666668 84.8469 13.784679941998307 331.07 280.185 146.71409638817943 122.514;190.233;145.958 84.8469;69.2223;96.7058 216.573;496.452;280.185 1 59107 LTBP1_33264 769.394 769.394 438.027 438.027 2211.2 2211.2 769.394 438.027 2211.2 0 Exp 2,1(0.25);Hill,1(0.25);Poly 2,2(0.5) 2.301276194522656 10.69605267047882 1.5140434503555298 5.5128583908081055 1.899552553265458 1.8345754146575928 3.69279655967307 610.3567034403269 -1.8227213590797362 346.2237213590797 -127.61089046834263 1729.8158904683426 UP 0.75 0.25 0.0 GO:0042133 4 neurotransmitter metabolic process 31 35 3 3 2 3 2 2 67 33 2445 0.9328 0.24469 0.24469 5.71 58835;25426 phgdh;cyp1b1 PHGDH_9470;CYP1B1_32710 176.0695 176.0695 122.826 75.29767980821177 191.53707809869186 72.0503201937489 126.49889999999999 126.49889999999999 67.6778 83.18559737370407 143.58680665716875 79.59805589693623 272.863 272.863 246.456 37.345137541586105 280.53440279756506 35.73455549233848 0.5 176.0695 122.826;229.313 67.6778;185.32 246.456;299.27 2 0 2 58835;25426 PHGDH_9470;CYP1B1_32710 176.0695 176.0695 75.29767980821177 126.49889999999999 126.49889999999999 83.18559737370407 272.863 272.863 37.345137541586105 122.826;229.313 67.6778;185.32 246.456;299.27 0 0 Exp 4,1(0.5);Linear,1(0.5) 2.3927062014433136 4.982239603996277 1.7978414297103882 3.1843981742858887 0.9804436765892801 2.4911198019981384 71.71224000000001 280.42676 11.209544000000008 241.788256 221.10528000000002 324.62072 UP 1.0 0.0 0.0 GO:0006355 7 regulation of transcription, DNA-templated 466 499 23 23 18 15 11 11 58 488 1990 0.27372 0.8224 0.53882 2.2 360243;259241;316351;64194;29200;25283;25317;24890;24309;25426;289185 top2a;nr1d2;npas2;insig1;inhba;gclc;fgf1;esr1;dbp;cyp1b1;creg1 TOP2A_10059;NR1D2_9358;NPAS2_9350;INSIG1_8906;INHBA_33300;GCLC_8699;FGF1_8633;ESR1_33192;DBP_8439;CYP1B1_32710;CREG1_8380 128.87408272727313 66.0377 4.48597E-12 193.00087921404963 149.3585474881065 215.93680934464618 77.65037363636405 19.9899 4.48597E-12 131.52345965710825 95.29498938031882 146.78656591187874 291.89876363636404 215.15 4.48599E-12 403.95551455995536 322.28361922828753 452.7850836494731 4.48597E-12;9.46041;53.0014;37.6554;91.8104;145.958;674.162;12.5403;66.0377;229.313;97.6763 4.48597E-12;2.2133;14.3825;13.2791;44.1594;96.7058;437.622;3.74981;19.9899;185.32;36.7323 4.48599E-12;49.4216;215.15;101.065;186.93;280.185;1465.0;51.2968;280.428;299.27;282.14 8 3 8 360243;259241;64194;25283;25317;24309;25426;289185 TOP2A_10059;NR1D2_9358;INSIG1_8906;GCLC_8699;FGF1_8633;DBP_8439;CYP1B1_32710;CREG1_8380 157.53285125000056 81.857 222.08713351258902 98.98280000000057 28.3611 150.59779102436067 344.68870000000055 280.3065 468.2350202651651 4.48597E-12;9.46041;37.6554;145.958;674.162;66.0377;229.313;97.6763 4.48597E-12;2.2133;13.2791;96.7058;437.622;19.9899;185.32;36.7323 4.48599E-12;49.4216;101.065;280.185;1465.0;280.428;299.27;282.14 3 316351;29200;24890 NPAS2_9350;INHBA_33300;ESR1_33192 52.450700000000005 53.0014 39.637919236130436 20.76390333333333 14.3825 20.94696809490656 151.1256 186.93 87.59813971814702 53.0014;91.8104;12.5403 14.3825;44.1594;3.74981 215.15;186.93;51.2968 0 Exp 4,2(0.19);Exp 5,1(0.1);Hill,5(0.46);Linear,2(0.19);Poly 2,1(0.1) 2.0051404550600727 22.57812488079071 1.5704141855239868 3.1843981742858887 0.49472408591993744 1.9026079177856445 14.817851718096591 242.93031373644973 -0.07502408651451731 155.3757713592426 53.17630976099801 530.62121751173 UP 0.7272727272727273 0.2727272727272727 0.0 GO:0031669 5 cellular response to nutrient levels 87 92 8 8 6 6 4 4 65 88 2390 0.89873 0.23711 0.31337 4.35 59107;24539;170496;25612 ltbp1;lpl;lcn2;asns LTBP1_33264;LPL_32544;LCN2_32481;ASNS_8091 662.04852 834.7560000000001 6.05608 445.34053704410843 669.5374493113422 465.37788915794084 370.04195000000004 462.74649999999997 2.7438 249.26687976626573 373.29648748534356 260.3523654415622 2434.621275 2819.79 14.3351 1790.4924307446363 2575.8598115219265 1894.0837579220047 769.394;900.118;972.626;6.05608 438.027;487.466;551.931;2.7438 2211.2;3428.38;4084.57;14.3351 2 2 2 170496;25612 LCN2_32481;ASNS_8091 489.34103999999996 489.34103999999996 683.4681449229388 277.3374 277.3374 388.3339932608528 2049.45255 2049.45255 2878.090698812149 972.626;6.05608 551.931;2.7438 4084.57;14.3351 2 59107;24539 LTBP1_33264;LPL_32544 834.7560000000001 834.7560000000001 92.43582686382874 462.74649999999997 462.74649999999997 34.958652155082945 2819.79 2819.79 860.6762319246413 769.394;900.118 438.027;487.466 2211.2;3428.38 0 Exp 2,2(0.5);Hill,1(0.25);Linear,1(0.25) 2.028155587264679 8.607132077217102 1.5140434503555298 3.5324413776397705 0.9310655502408809 1.7803236246109009 225.6147936967738 1098.4822463032262 125.7604078290596 614.3234921709404 679.9386928702563 4189.303857129744 CONFLICT 0.5 0.5 0.0 GO:0032651 7 regulation of interleukin-1 beta production 32 33 6 6 6 3 3 3 66 30 2448 0.98884 0.058181 0.058181 9.09 24614;24539;24426 orm1;lpl;gstp1 ORM1_9400;LPL_32544;GSTP1_8762 561.7073333333334 662.49 122.514 398.4781733411923 681.2043197128659 351.8268425220308 334.91929999999996 432.445 84.8469 218.30937117212815 395.20746765599114 184.54125371847996 1686.0910000000001 1413.32 216.573 1623.1848524253178 2203.7251641358366 1590.2289414840473 0.5 392.502 662.49;900.118;122.514 432.445;487.466;84.8469 1413.32;3428.38;216.573 2 1 2 24614;24426 ORM1_9400;GSTP1_8762 392.502 392.502 381.8206912779871 258.64594999999997 258.64594999999997 245.7889736375597 814.9465 814.9465 846.227919064657 662.49;122.514 432.445;84.8469 1413.32;216.573 1 24539 LPL_32544 900.118 900.118 487.466 487.466 3428.38 3428.38 900.118 487.466 3428.38 0 Exp 2,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 2.4410862661510535 8.765297651290894 1.5487829446792603 5.5128583908081055 2.245287670949396 1.7036563158035278 110.78683126966695 1012.6278353969999 87.87899054282167 581.9596094571784 -150.71557452486923 3522.897574524869 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0021953 6 central nervous system neuron differentiation 21 22 2 2 2 2 2 2 67 20 2458 0.97973 0.1181 0.1181 9.09 360243;29200 top2a;inhba TOP2A_10059;INHBA_33300 45.905200000002246 45.905200000002246 4.48597E-12 64.91975642344622 40.254884965404074 64.42610227306301 22.07970000000224 22.07970000000224 4.48597E-12 31.225411193126053 19.36198477668526 30.987971087338135 93.46500000000225 93.46500000000225 4.48599E-12 132.17947060719814 81.96071084084966 131.17436911182142 0.5 45.905200000002246 4.48597E-12;91.8104 4.48597E-12;44.1594 4.48599E-12;186.93 1 1 1 360243 TOP2A_10059 4.48597E-12 4.48597E-12 4.48597E-12 4.48597E-12 4.48599E-12 4.48599E-12 4.48597E-12 4.48597E-12 4.48599E-12 1 29200 INHBA_33300 91.8104 91.8104 44.1594 44.1594 186.93 186.93 91.8104 44.1594 186.93 0 Hill,2(1) 2.0046551862536286 4.04544985294342 1.75295889377594 2.2924909591674805 0.3815067821059421 2.02272492647171 -44.06899199999336 135.87939199999784 -21.19651199999336 65.35591199999784 -89.72639999999336 276.65639999999786 CONFLICT 0.5 0.5 0.0 GO:0044237 3 cellular metabolic process 1201 1328 82 81 72 55 47 47 22 1281 1197 0.99782 0.0046873 0.0071262 3.54 83472;360243;266730;171497;94195;291317;293656;287877;293820;58835;361042;680308;313108;24552;29685;312538;24539;287167;116682;293502;64194;29200;360504;84029;24426;300850;116686;24404;29739;25283;499709;24890;25315;171142;298452;25426;24296;290277;310395;54232;81508;25612;24207;25748;26760;360887;296925 ugdh;top2a;slc17a3;sgk2;s100a9;rpp38;rgd1307603;pycr1;psat1;phgdh;pck2;mthfd2;mms22l;me1;mcm6;mcm2;lpl;hba-a1;kynu;kif22;insig1;inhba;hba-a2;hao2;gstp1;gsta4;gsr;gpx1;gclm;gclc;gar1;esr1;ephx1;ehhadh;dph2;cyp1b1;cyp1a1;cryl1;noct;car3;bhmt;asns;apoc3;alas2;akr7a3;coq8a;aass UGDH_10131;TOP2A_10059;SLC17A3_9840;SGK2_32380;S100A9_9775;RPP38_9741;RGD1307603_9684;PYCR1_9631;PSAT1_9583;PHGDH_9470;PCK2_9440;MTHFD2_9261;MMS22L_33129;ME1_9215;MCM6_9210;MCM2_9206;LPL_32544;LOC287167_9118;KYNU_8979;KIF22_8963;INSIG1_8906;INHBA_33300;HBA2_32600;HAO2_8778;GSTP1_8762;GSTA4_8757;GSR_8755;GPX1_33050;GCLM_8700;GCLC_8699;GAR1_8683;ESR1_33192;EPHX1_8567;EHHADH_8534;DPH2_8490;CYP1B1_32710;CYP1A1_8415;CRYL1_8388;CCRN4L_8232;CAR3_8196;BHMT_8143;ASNS_8091;APOC3_32553;ALAS2_8019;AKR7A3_8015;ADCK3_7987;AASS_7936 499709(-0.07184) 192.17994012765965 91.8104 4.48597E-12 276.843131156671 155.1609697282339 239.8695281336156 131.0461559787235 63.0271 4.48597E-12 203.75793422327624 105.17564430509563 174.5612033070301 388.4410363829788 143.418 4.48599E-12 631.3254099783528 311.73022156109374 544.7313814199832 59.3662;4.48597E-12;93.3839;156.37;963.318;916.962;32.0155;132.668;27.1579;122.826;6.67763;622.58;4.13516;13.1175;1.87441;3.76863;900.118;149.282;100.381;0.961856;37.6554;91.8104;131.05;140.856;122.514;339.498;69.5519;8.00432;190.233;145.958;765.364;12.5403;27.5708;166.899;734.134;229.313;83.0393;32.8011;665.276;3.44933;5.5396;6.05608;2.87451;125.506;57.1167;525.072;5.81076 25.4417;4.48597E-12;68.9252;100.616;802.143;769.912;12.3892;90.3184;10.0144;67.6778;1.48195;414.266;1.24709;6.20444;0.496857;0.956203;487.466;97.0024;72.7231;0.281971;13.2791;44.1594;88.5948;93.5219;84.8469;260.156;41.1016;2.69961;69.2223;96.7058;587.034;3.74981;12.6303;105.26;463.289;185.32;63.0271;15.4462;433.686;2.13143;1.97501;2.7438;1.13737;85.7907;33.0666;336.426;2.60489 135.068;4.48599E-12;143.418;343.205;1158.68;1051.72;78.5761;239.858;103.876;246.456;37.9425;1250.29;20.8956;28.4614;9.53;22.9217;3428.38;334.152;161.456;4.47267;101.065;186.93;254.163;282.925;216.573;486.944;124.212;25.2254;496.452;280.185;1362.21;51.2968;61.9858;384.658;1764.85;299.27;119.986;74.622;1425.48;6.02113;37.8319;14.3351;8.23841;236.762;102.949;1038.12;14.0792 29 18 29 83472;360243;266730;171497;94195;287877;293820;58835;361042;680308;313108;24552;29685;312538;293502;64194;24426;300850;116686;29739;25283;499709;25315;25426;24296;290277;310395;25612;26760 UGDH_10131;TOP2A_10059;SLC17A3_9840;SGK2_32380;S100A9_9775;PYCR1_9631;PSAT1_9583;PHGDH_9470;PCK2_9440;MTHFD2_9261;MMS22L_33129;ME1_9215;MCM6_9210;MCM2_9206;KIF22_8963;INSIG1_8906;GSTP1_8762;GSTA4_8757;GSR_8755;GCLM_8700;GCLC_8699;GAR1_8683;EPHX1_8567;CYP1B1_32710;CYP1A1_8415;CRYL1_8388;CCRN4L_8232;ASNS_8091;AKR7A3_8015 171.7293953793105 69.5519 254.79178096906375 120.2874727931036 41.1016 197.05388086752052 307.28771620689673 124.212 426.89984428318365 59.3662;4.48597E-12;93.3839;156.37;963.318;132.668;27.1579;122.826;6.67763;622.58;4.13516;13.1175;1.87441;3.76863;0.961856;37.6554;122.514;339.498;69.5519;190.233;145.958;765.364;27.5708;229.313;83.0393;32.8011;665.276;6.05608;57.1167 25.4417;4.48597E-12;68.9252;100.616;802.143;90.3184;10.0144;67.6778;1.48195;414.266;1.24709;6.20444;0.496857;0.956203;0.281971;13.2791;84.8469;260.156;41.1016;69.2223;96.7058;587.034;12.6303;185.32;63.0271;15.4462;433.686;2.7438;33.0666 135.068;4.48599E-12;143.418;343.205;1158.68;239.858;103.876;246.456;37.9425;1250.29;20.8956;28.4614;9.53;22.9217;4.47267;101.065;216.573;486.944;124.212;496.452;280.185;1362.21;61.9858;299.27;119.986;74.622;1425.48;14.3351;102.949 18 291317;293656;24539;287167;116682;29200;360504;84029;24404;24890;171142;298452;54232;81508;24207;25748;360887;296925 RPP38_9741;RGD1307603_9684;LPL_32544;LOC287167_9118;KYNU_8979;INHBA_33300;HBA2_32600;HAO2_8778;GPX1_33050;ESR1_33192;EHHADH_8534;DPH2_8490;CAR3_8196;BHMT_8143;APOC3_32553;ALAS2_8019;ADCK3_7987;AASS_7936 225.12804 112.9435 314.000817758952 148.37959 79.2569 218.79137503301638 519.1880522222223 211.846 865.4406614755547 916.962;32.0155;900.118;149.282;100.381;91.8104;131.05;140.856;8.00432;12.5403;166.899;734.134;3.44933;5.5396;2.87451;125.506;525.072;5.81076 769.912;12.3892;487.466;97.0024;72.7231;44.1594;88.5948;93.5219;2.69961;3.74981;105.26;463.289;2.13143;1.97501;1.13737;85.7907;336.426;2.60489 1051.72;78.5761;3428.38;334.152;161.456;186.93;254.163;282.925;25.2254;51.2968;384.658;1764.85;6.02113;37.8319;8.23841;236.762;1038.12;14.0792 0 Exp 2,3(0.07);Exp 4,9(0.2);Exp 5,1(0.03);Hill,15(0.32);Linear,5(0.11);Poly 2,14(0.3) 2.0804352341084518 107.09770500659943 1.5039241313934326 6.759152412414551 1.2392765563326227 1.7646474838256836 113.03176702171974 271.32811323359954 72.7927032662343 189.29960869121277 207.9480162875402 568.9340564784173 UP 0.6170212765957447 0.3829787234042553 0.0 GO:0030193 5 regulation of blood coagulation 45 46 2 2 2 2 2 2 67 44 2434 0.87327 0.35592 0.35592 4.35 94195;288001 s100a9;kng1 S100A9_9775;KNG1L1_32433 288001(0.1788) 483.59677999999997 483.59677999999997 3.87556 678.4282554821673 279.1319236603462 613.7207368833045 401.699055 401.699055 1.25511 566.3132579891858 231.02344117889527 512.2991078148627 586.2587 586.2587 13.8374 809.5259658512382 342.28358697444355 732.3145347702132 963.318;3.87556 802.143;1.25511 1158.68;13.8374 2 0 2 94195;288001 S100A9_9775;KNG1L1_32433 483.59677999999997 483.59677999999997 678.4282554821673 401.699055 401.699055 566.3132579891858 586.2587 586.2587 809.5259658512382 963.318;3.87556 802.143;1.25511 1158.68;13.8374 0 0 Exp 4,1(0.5);Poly 2,1(0.5) 1.6393119734010648 3.281202554702759 1.5755720138549805 1.7056305408477783 0.091965266387741 1.6406012773513794 -456.6568112 1423.8503712 -383.17107720000007 1186.5691872 -535.6870480000001 1708.204448 UP 1.0 0.0 0.0 GO:0044272 5 sulfur compound biosynthetic process 25 31 5 5 5 5 5 5 64 26 2452 0.99986 0.0012393 0.0012393 16.13 83472;24426;29739;25283;81508 ugdh;gstp1;gclm;gclc;bhmt UGDH_10131;GSTP1_8762;GCLM_8700;GCLC_8699;BHMT_8143 104.72215999999999 122.514 5.5396 72.84125058006627 100.50454461813729 81.14429957400871 55.638342 69.2223 1.97501 40.36022259411264 50.05735936105095 42.22950947667049 233.22197999999997 216.573 37.8319 172.9047746333282 234.90773429230623 192.42971089985315 0.5 32.4529 2.5 134.236 59.3662;122.514;190.233;145.958;5.5396 25.4417;84.8469;69.2223;96.7058;1.97501 135.068;216.573;496.452;280.185;37.8319 4 1 4 83472;24426;29739;25283 UGDH_10131;GSTP1_8762;GCLM_8700;GCLC_8699 129.51780000000002 134.236 54.54941455255647 69.054175 77.03460000000001 31.17744253840961 282.0695 248.37900000000002 154.7714876422657 59.3662;122.514;190.233;145.958 25.4417;84.8469;69.2223;96.7058 135.068;216.573;496.452;280.185 1 81508 BHMT_8143 5.5396 5.5396 1.97501 1.97501 37.8319 37.8319 5.5396 1.97501 37.8319 0 Exp 4,1(0.2);Hill,2(0.4);Poly 2,2(0.4) 2.1757428305267985 12.428256511688232 1.5737498998641968 5.5128583908081055 1.6967308352539259 1.7603585720062256 40.87398875765537 168.57033124234465 20.26104708747617 91.01563691252383 81.66426275195403 384.779697248046 UP 0.8 0.2 0.0 GO:0043124 8 negative regulation of I-kappaB kinase/NF-kappaB signaling 16 18 3 3 2 3 2 2 67 16 2462 0.9884 0.083748 0.083748 11.11 24426;24890 gstp1;esr1 GSTP1_8762;ESR1_33192 67.52714999999999 67.52714999999999 12.5403 77.76314902217503 31.658174354362068 58.94014351959339 44.298355 44.298355 3.74981 57.344302273495764 17.84776230245407 43.46379292159291 133.9349 133.9349 51.2968 116.86792178874408 80.02848426056791 88.57938714777279 0.0 12.5403 0.5 67.52714999999999 122.514;12.5403 84.8469;3.74981 216.573;51.2968 1 1 1 24426 GSTP1_8762 122.514 122.514 84.8469 84.8469 216.573 216.573 122.514 84.8469 216.573 1 24890 ESR1_33192 12.5403 12.5403 3.74981 3.74981 51.2968 51.2968 12.5403 3.74981 51.2968 0 Hill,1(0.5);Poly 2,1(0.5) 3.0899045833597882 7.244720458984375 1.7318620681762695 5.5128583908081055 2.6735681393743707 3.6223602294921875 -40.24707599999998 175.301376 -35.17679319999999 123.7735032 -28.035776 295.905576 CONFLICT 0.5 0.5 0.0 GO:0042445 4 hormone metabolic process 53 64 9 9 7 6 4 4 65 60 2418 0.97208 0.093104 0.093104 6.25 299270;24890;25426;24296 serpina6;esr1;cyp1b1;cyp1a1 SERPINA6_32325;ESR1_33192;CYP1B1_32710;CYP1A1_8415 87.666775 54.4069 12.5403 99.26346681471402 104.03835519623233 102.3647642759643 65.0676575 35.60041 3.74981 84.58051055638306 79.23281703673469 87.01487361928244 143.4567 111.63 51.2968 107.91471132747994 159.13352740973312 112.70573337447225 2.5 156.17615 25.7745;12.5403;229.313;83.0393 8.17372;3.74981;185.32;63.0271 103.274;51.2968;299.27;119.986 2 2 2 25426;24296 CYP1B1_32710;CYP1A1_8415 156.17615 156.17615 103.43112517924666 124.17354999999999 124.17354999999999 86.47413888096834 209.628 209.628 126.77293215824898 229.313;83.0393 185.32;63.0271 299.27;119.986 2 299270;24890 SERPINA6_32325;ESR1_33192 19.1574 19.1574 9.357992563579009 5.961765 5.961765 3.128176760358978 77.2854 77.2854 36.75343058708943 25.7745;12.5403 8.17372;3.74981 103.274;51.2968 0 Hill,2(0.5);Linear,1(0.25);Poly 2,1(0.25) 2.893427389178674 13.228420495986938 1.7318620681762695 6.292444229125977 2.086948964940236 2.602057099342346 -9.611422478419755 184.94497247841974 -17.821242845255384 147.95655784525536 37.700282899069634 249.21311710093033 CONFLICT 0.5 0.5 0.0 GO:0045766 7 positive regulation of angiogenesis 68 69 2 2 2 2 2 2 67 67 2411 0.71313 0.56428 0.71071 2.9 25317;25426 fgf1;cyp1b1 FGF1_8633;CYP1B1_32710 451.7375 451.7375 229.313 314.55574450405453 425.4957763814867 312.35886458296517 311.471 311.471 185.32 178.40445510692828 296.5876590182328 177.15846557373695 882.135 882.135 299.27 824.295588032594 813.3683747545583 818.5386484184517 674.162;229.313 437.622;185.32 1465.0;299.27 2 0 2 25317;25426 FGF1_8633;CYP1B1_32710 451.7375 451.7375 314.55574450405453 311.471 311.471 178.40445510692828 882.135 882.135 824.295588032594 674.162;229.313 437.622;185.32 1465.0;299.27 0 0 Linear,2(1) 2.2362522365008926 4.7548123598098755 1.5704141855239868 3.1843981742858887 1.1412590231800532 2.3774061799049377 15.78547999999995 887.6895200000001 64.21503999999999 558.72696 -260.2803999999999 2024.5503999999999 UP 1.0 0.0 0.0 GO:0018193 7 peptidyl-amino acid modification 169 184 5 5 4 4 3 3 66 181 2297 0.25291 0.88672 0.48052 1.63 171497;94195;298452 sgk2;s100a9;dph2 SGK2_32380;S100A9_9775;DPH2_8490 617.9406666666667 734.134 156.37 415.8328230302814 508.7149785686654 395.57998087599316 455.34933333333333 463.289 100.616 350.8308875545785 348.0396112959381 301.29051311155047 1088.9116666666666 1158.68 343.205 713.3858295188749 1052.6622564796903 811.2217471527646 156.37;963.318;734.134 100.616;802.143;463.289 343.205;1158.68;1764.85 2 1 2 171497;94195 SGK2_32380;S100A9_9775 559.844 559.844 570.5984028649219 451.3795 451.3795 496.05449888545513 750.9425 750.9425 576.6279023881 156.37;963.318 100.616;802.143 343.205;1158.68 1 298452 DPH2_8490 734.134 734.134 463.289 463.289 1764.85 1764.85 734.134 463.289 1764.85 0 Linear,1(0.34);Poly 2,2(0.67) 1.76070888650828 5.2899240255355835 1.6845101118087769 1.8997833728790283 0.11866196501011246 1.7056305408477783 147.38152973041343 1088.49980360292 58.34681088877767 852.351855777889 281.6396052774444 1896.1837280558889 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0008610 5 lipid biosynthetic process 109 122 15 15 13 6 4 4 65 118 2360 0.76677 0.42321 0.57066 3.28 24539;64194;24426;24296 lpl;insig1;gstp1;cyp1a1 LPL_32544;INSIG1_8906;GSTP1_8762;CYP1A1_8415 285.831675 102.77664999999999 37.6554 410.9892792115254 220.47201319344782 369.1706017969486 162.154775 73.937 13.2791 218.93238165061186 127.24076100361262 196.94723895577806 966.501 168.2795 101.065 1642.0320065035273 717.9792920275154 1468.5617912232499 900.118;37.6554;122.514;83.0393 487.466;13.2791;84.8469;63.0271 3428.38;101.065;216.573;119.986 3 1 3 64194;24426;24296 INSIG1_8906;GSTP1_8762;CYP1A1_8415 81.06956666666666 83.0393 42.46357716376865 53.7177 63.0271 36.68086961182901 145.87466666666668 119.986 61.95314206990098 37.6554;122.514;83.0393 13.2791;84.8469;63.0271 101.065;216.573;119.986 1 24539 LPL_32544 900.118 900.118 487.466 487.466 3428.38 3428.38 900.118 487.466 3428.38 0 Exp 2,1(0.25);Exp 5,1(0.25);Poly 2,2(0.5) 3.283371476727512 15.475494861602783 1.7036563158035278 6.292444229125977 2.372300929546829 3.7396971583366394 -116.93781862729486 688.6011686272949 -52.39895901759965 376.70850901759957 -642.6903663734568 2575.692366373457 UP 0.75 0.25 0.0 GO:0051346 6 negative regulation of hydrolase activity 118 128 8 8 7 6 5 5 64 123 2355 0.86992 0.26424 0.39325 3.91 299270;312538;288001;24404;24207 serpina6;mcm2;kng1;gpx1;apoc3 SERPINA6_32325;MCM2_9206;KNG1L1_32433;GPX1_33050;APOC3_32553 288001(0.1788) 8.859504 3.87556 2.87451 9.662107410044145 8.588165307572803 9.638222062185728 2.8444026 1.25511 0.956203 3.058909031103867 2.799659652067563 3.0226427128934783 34.699382 22.9217 8.23841 38.94340025674594 32.83308062241761 39.288013523030116 25.7745;3.76863;3.87556;8.00432;2.87451 8.17372;0.956203;1.25511;2.69961;1.13737 103.274;22.9217;13.8374;25.2254;8.23841 2 3 2 312538;288001 MCM2_9206;KNG1L1_32433 3.822095 3.822095 0.07561092811229443 1.1056565 1.1056565 0.21135916664412677 18.379550000000002 18.379550000000002 6.423570132332945 3.76863;3.87556 0.956203;1.25511 22.9217;13.8374 3 299270;24404;24207 SERPINA6_32325;GPX1_33050;APOC3_32553 12.217776666666666 8.00432 12.017374851082634 4.003566666666667 2.69961 3.6949671949874374 45.57927 25.2254 50.68185927572804 25.7745;8.00432;2.87451 8.17372;2.69961;1.13737 103.274;25.2254;8.23841 0 Exp 4,2(0.4);Hill,3(0.6) 1.6759232840239084 8.431517839431763 1.5235437154769897 2.0197160243988037 0.21484309863862833 1.5755720138549805 0.39029344189284565 17.32871455810715 0.16315061602978398 5.525654583970216 0.563986622365853 68.83477737763414 DOWN 0.4 0.6 0.0 GO:0031324 6 negative regulation of cellular metabolic process 513 545 26 26 20 15 10 10 59 535 1943 0.098591 0.94697 0.18119 1.83 299270;259241;288001;64194;24426;24404;25283;24890;310395;24207 serpina6;nr1d2;kng1;insig1;gstp1;gpx1;gclc;esr1;noct;apoc3 SERPINA6_32325;NR1D2_9358;KNG1L1_32433;INSIG1_8906;GSTP1_8762;GPX1_33050;GCLC_8699;ESR1_33192;CCRN4L_8232;APOC3_32553 288001(0.1788) 103.3933 19.1574 2.87451 203.96628089512032 95.2700329438295 210.589796966394 64.774672 5.961765 1.13737 134.55656977863322 58.90081022517758 138.71742503493894 227.459661 76.1809 8.23841 430.3578524531389 215.7761191519907 444.63916144222287 25.7745;9.46041;3.87556;37.6554;122.514;8.00432;145.958;12.5403;665.276;2.87451 8.17372;2.2133;1.25511;13.2791;84.8469;2.69961;96.7058;3.74981;433.686;1.13737 103.274;49.4216;13.8374;101.065;216.573;25.2254;280.185;51.2968;1425.48;8.23841 6 4 6 259241;288001;64194;24426;25283;310395 NR1D2_9358;KNG1L1_32433;INSIG1_8906;GSTP1_8762;GCLC_8699;CCRN4L_8232 164.12322833333334 80.0847 252.5111554512033 105.331035 49.063 166.28265193882055 347.76033333333334 158.81900000000002 537.5175038496242 9.46041;3.87556;37.6554;122.514;145.958;665.276 2.2133;1.25511;13.2791;84.8469;96.7058;433.686 49.4216;13.8374;101.065;216.573;280.185;1425.48 4 299270;24404;24890;24207 SERPINA6_32325;GPX1_33050;ESR1_33192;APOC3_32553 12.2984075 10.272310000000001 9.813470548150892 3.9401275 3.22471 3.0195948667812478 47.0086525 38.2611 41.4801933910032 25.7745;8.00432;12.5403;2.87451 8.17372;2.69961;3.74981;1.13737 103.274;25.2254;51.2968;8.23841 0 Exp 4,2(0.2);Exp 5,1(0.1);Hill,4(0.4);Linear,1(0.1);Poly 2,2(0.2) 2.013299582190818 21.80959963798523 1.5235437154769897 5.5128583908081055 1.1873034634972115 1.7724979519844055 -23.026310646444415 229.8129106464444 -18.62435398941247 148.17369798941246 -39.27889944735773 494.1982214473578 UP 0.6 0.4 0.0 GO:0006812 6 cation transport 135 141 4 4 4 3 3 3 66 138 2340 0.46248 0.74649 1.0 2.13 266730;170496;301111 slc17a3;lcn2;ano10 SLC17A3_9840;LCN2_32481;ANO10_8049 358.6435333333333 93.3839 9.9207 533.359520838546 293.75342265396347 488.32040738532805 207.92423333333332 68.9252 2.9165 299.7411862812039 173.24009213525125 273.4560824131575 1420.3921 143.418 33.1883 2307.9039318885934 1116.922205479793 2127.1632767939955 93.3839;972.626;9.9207 68.9252;551.931;2.9165 143.418;4084.57;33.1883 3 0 3 266730;170496;301111 SLC17A3_9840;LCN2_32481;ANO10_8049 358.6435333333333 93.3839 533.359520838546 207.92423333333332 68.9252 299.7411862812039 1420.3921 143.418 2307.9039318885934 93.3839;972.626;9.9207 68.9252;551.931;2.9165 143.418;4084.57;33.1883 0 0 Hill,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 1.6386980048877449 4.93655002117157 1.504341721534729 1.856990933418274 0.18653916783698216 1.575217366218567 -244.90958201139586 962.1966486780626 -131.26484965654146 547.1133163232082 -1191.2470544257635 4032.0312544257636 UP 1.0 0.0 0.0 GO:0009058 3 biosynthetic process 416 466 39 39 35 29 25 25 44 441 2037 0.99991 2.6679E-4 3.6836E-4 5.36 83472;287877;293820;58835;361042;29685;24539;116682;64194;29200;84029;24426;29739;25283;499709;24890;25315;298452;25426;24296;81508;25612;25748;360887;296925 ugdh;pycr1;psat1;phgdh;pck2;mcm6;lpl;kynu;insig1;inhba;hao2;gstp1;gclm;gclc;gar1;esr1;ephx1;dph2;cyp1b1;cyp1a1;bhmt;asns;alas2;coq8a;aass UGDH_10131;PYCR1_9631;PSAT1_9583;PHGDH_9470;PCK2_9440;MCM6_9210;LPL_32544;KYNU_8979;INSIG1_8906;INHBA_33300;HAO2_8778;GSTP1_8762;GCLM_8700;GCLC_8699;GAR1_8683;ESR1_33192;EPHX1_8567;DPH2_8490;CYP1B1_32710;CYP1A1_8415;BHMT_8143;ASNS_8091;ALAS2_8019;ADCK3_7987;AASS_7936 499709(-0.07184) 184.00167120000003 100.381 1.87441 257.370159083075 142.7266511539579 217.3062240226152 116.07784867999999 67.6778 0.496857 167.09018074240564 89.88102267238172 137.29123418206228 437.0969319999999 186.93 9.53 760.0919642990872 330.6947260396082 647.9997502409753 22.5 749.749 59.3662;132.668;27.1579;122.826;6.67763;1.87441;900.118;100.381;37.6554;91.8104;140.856;122.514;190.233;145.958;765.364;12.5403;27.5708;734.134;229.313;83.0393;5.5396;6.05608;125.506;525.072;5.81076 25.4417;90.3184;10.0144;67.6778;1.48195;0.496857;487.466;72.7231;13.2791;44.1594;93.5219;84.8469;69.2223;96.7058;587.034;3.74981;12.6303;463.289;185.32;63.0271;1.97501;2.7438;85.7907;336.426;2.60489 135.068;239.858;103.876;246.456;37.9425;9.53;3428.38;161.456;101.065;186.93;282.925;216.573;496.452;280.185;1362.21;51.2968;61.9858;1764.85;299.27;119.986;37.8319;14.3351;236.762;1038.12;14.0792 15 10 15 83472;287877;293820;58835;361042;29685;64194;24426;29739;25283;499709;25315;25426;24296;25612 UGDH_10131;PYCR1_9631;PSAT1_9583;PHGDH_9470;PCK2_9440;MCM6_9210;INSIG1_8906;GSTP1_8762;GCLM_8700;GCLC_8699;GAR1_8683;EPHX1_8567;CYP1B1_32710;CYP1A1_8415;ASNS_8091 130.55158133333333 83.0393 189.23154587999596 87.34936046666665 63.0271 147.2728287047027 248.31949333333333 135.068 334.83547276866864 59.3662;132.668;27.1579;122.826;6.67763;1.87441;37.6554;122.514;190.233;145.958;765.364;27.5708;229.313;83.0393;6.05608 25.4417;90.3184;10.0144;67.6778;1.48195;0.496857;13.2791;84.8469;69.2223;96.7058;587.034;12.6303;185.32;63.0271;2.7438 135.068;239.858;103.876;246.456;37.9425;9.53;101.065;216.573;496.452;280.185;1362.21;61.9858;299.27;119.986;14.3351 10 24539;116682;29200;84029;24890;298452;81508;25748;360887;296925 LPL_32544;KYNU_8979;INHBA_33300;HAO2_8778;ESR1_33192;DPH2_8490;BHMT_8143;ALAS2_8019;ADCK3_7987;AASS_7936 264.176806 112.9435 330.20049052483444 159.170581 79.2569 193.0628431520975 720.26309 211.846 1103.5177789667816 900.118;100.381;91.8104;140.856;12.5403;734.134;5.5396;125.506;525.072;5.81076 487.466;72.7231;44.1594;93.5219;3.74981;463.289;1.97501;85.7907;336.426;2.60489 3428.38;161.456;186.93;282.925;51.2968;1764.85;37.8319;236.762;1038.12;14.0792 0 Exp 2,3(0.12);Exp 4,2(0.08);Exp 5,1(0.04);Hill,10(0.4);Linear,2(0.08);Poly 2,7(0.28) 2.1565085815631333 58.58368170261383 1.528982162475586 6.292444229125977 1.1982480393492927 1.8211764097213745 83.11256883943457 284.8907735605654 50.57849782897698 181.57719953102298 139.14088199475788 735.052982005242 UP 0.6 0.4 0.0 GO:0051641 3 cellular localization 308 325 5 5 5 2 2 2 67 323 2155 0.0045721 0.99919 0.0092085 0.62 293502;24890 kif22;esr1 KIF22_8963;ESR1_33192 6.751078 6.751078 0.961856 8.187196267988694 6.322941541873696 8.164776854085732 2.0158905000000003 2.0158905000000003 0.281971 2.452132472963175 1.8876601171599339 2.445417674507543 27.884735 27.884735 4.47267 33.109659846160454 26.153317792899834 33.018993988890166 0.961856;12.5403 0.281971;3.74981 4.47267;51.2968 1 1 1 293502 KIF22_8963 0.961856 0.961856 0.281971 0.281971 4.47267 4.47267 0.961856 0.281971 4.47267 1 24890 ESR1_33192 12.5403 12.5403 3.74981 3.74981 51.2968 51.2968 12.5403 3.74981 51.2968 0 Exp 4,1(0.5);Hill,1(0.5) 1.9034386206786522 3.8238754272460938 1.7318620681762695 2.092013359069824 0.2546654200439214 1.9119377136230469 -4.595797119999998 18.09795312 -1.3825917199999993 5.414372719999999 -18.002912399999992 73.7723824 CONFLICT 0.5 0.5 0.0 GO:0051173 6 positive regulation of nitrogen compound metabolic process 649 698 28 28 23 15 11 11 58 687 1791 0.017578 0.99212 0.028821 1.58 360243;94195;259241;316351;64194;29200;25283;25317;24890;24309;25426 top2a;s100a9;nr1d2;npas2;insig1;inhba;gclc;fgf1;esr1;dbp;cyp1b1 TOP2A_10059;S100A9_9775;NR1D2_9358;NPAS2_9350;INSIG1_8906;INHBA_33300;GCLC_8699;FGF1_8633;ESR1_33192;DBP_8439;CYP1B1_32710 207.56878272727315 66.0377 4.48597E-12 316.1795896814541 172.29200126292656 255.50254146227695 147.23316454545494 19.9899 4.48597E-12 253.56262907006564 115.62984249600564 188.37875254990533 371.58421818181864 215.15 4.48599E-12 480.954006881227 345.4519643763758 474.8251278670911 4.48597E-12;963.318;9.46041;53.0014;37.6554;91.8104;145.958;674.162;12.5403;66.0377;229.313 4.48597E-12;802.143;2.2133;14.3825;13.2791;44.1594;96.7058;437.622;3.74981;19.9899;185.32 4.48599E-12;1158.68;49.4216;215.15;101.065;186.93;280.185;1465.0;51.2968;280.428;299.27 8 3 8 360243;94195;259241;64194;25283;25317;24309;25426 TOP2A_10059;S100A9_9775;NR1D2_9358;INSIG1_8906;GCLC_8699;FGF1_8633;DBP_8439;CYP1B1_32710 265.7380637500006 105.99785 358.0300903603381 194.65913750000055 58.347849999999994 286.8761087210189 454.25620000000055 280.3065 547.3752225162548 4.48597E-12;963.318;9.46041;37.6554;145.958;674.162;66.0377;229.313 4.48597E-12;802.143;2.2133;13.2791;96.7058;437.622;19.9899;185.32 4.48599E-12;1158.68;49.4216;101.065;280.185;1465.0;280.428;299.27 3 316351;29200;24890 NPAS2_9350;INHBA_33300;ESR1_33192 52.450700000000005 53.0014 39.637919236130436 20.76390333333333 14.3825 20.94696809490656 151.1256 186.93 87.59813971814702 53.0014;91.8104;12.5403 14.3825;44.1594;3.74981 215.15;186.93;51.2968 0 Exp 4,1(0.1);Exp 5,1(0.1);Hill,5(0.46);Linear,2(0.19);Poly 2,2(0.19) 2.017035490861225 22.685563921928406 1.5704141855239868 3.1843981742858887 0.48583740453425633 1.9026079177856445 20.718585629987473 394.41897982455873 -2.612773536697972 297.0791026276079 87.35856316396803 655.8098731996691 UP 0.7272727272727273 0.2727272727272727 0.0 GO:0006564 9 L-serine biosynthetic process 2 2 2 2 2 2 2 2 67 0 2478 1.0 7.2355E-4 7.2355E-4 100.0 293820;58835 psat1;phgdh PSAT1_9583;PHGDH_9470 74.99195 74.99195 27.1579 67.64756225323272 107.98298510178903 48.983424590671916 38.8461 38.8461 10.0144 40.77418116627237 58.731257680444166 29.524478959462503 175.166 175.166 103.876 100.81928486157796 224.3345502776064 73.00298300204574 0.0 27.1579 0.0 27.1579 27.1579;122.826 10.0144;67.6778 103.876;246.456 2 0 2 293820;58835 PSAT1_9583;PHGDH_9470 74.99195 74.99195 67.64756225323272 38.8461 38.8461 40.77418116627237 175.166 175.166 100.81928486157796 27.1579;122.826 10.0144;67.6778 103.876;246.456 0 0 Exp 4,1(0.5);Hill,1(0.5) 2.0662078807241833 4.172475218772888 1.7978414297103882 2.3746337890625 0.4078537886344662 2.086237609386444 -18.762787999999986 168.746688 -17.66403199999999 95.35623199999999 35.43760000000003 314.89439999999996 UP 1.0 0.0 0.0 GO:0010033 4 response to organic substance 795 856 59 59 47 40 29 29 40 827 1651 0.94658 0.086535 0.15477 3.39 360243;94195;361042;24614;24552;312538;59107;24539;170496;116682;64194;29200;25663;360504;24426;116686;24404;29739;25283;24890;25315;25426;24296;310395;54232;81508;25612;24207;25748 top2a;s100a9;pck2;orm1;me1;mcm2;ltbp1;lpl;lcn2;kynu;insig1;inhba;il1r1;hba-a2;gstp1;gsr;gpx1;gclm;gclc;esr1;ephx1;cyp1b1;cyp1a1;noct;car3;bhmt;asns;apoc3;alas2 TOP2A_10059;S100A9_9775;PCK2_9440;ORM1_9400;ME1_9215;MCM2_9206;LTBP1_33264;LPL_32544;LCN2_32481;KYNU_8979;INSIG1_8906;INHBA_33300;IL1R1_8893;HBA2_32600;GSTP1_8762;GSR_8755;GPX1_33050;GCLM_8700;GCLC_8699;ESR1_33192;EPHX1_8567;CYP1B1_32710;CYP1A1_8415;CCRN4L_8232;CAR3_8196;BHMT_8143;ASNS_8091;APOC3_32553;ALAS2_8019 221.601879310345 83.0393 4.48597E-12 323.5060559310447 159.44616519198485 266.5191878613857 139.78276631034495 44.1594 4.48597E-12 213.05398878860163 99.47912287452328 168.86115877886607 575.1064531034485 161.456 4.48599E-12 1032.2700569698823 413.2475604561021 887.4602056056464 4.48597E-12;963.318;6.67763;662.49;13.1175;3.76863;769.394;900.118;972.626;100.381;37.6554;91.8104;76.6218;131.05;122.514;69.5519;8.00432;190.233;145.958;12.5403;27.5708;229.313;83.0393;665.276;3.44933;5.5396;6.05608;2.87451;125.506 4.48597E-12;802.143;1.48195;432.445;6.20444;0.956203;438.027;487.466;551.931;72.7231;13.2791;44.1594;27.5215;88.5948;84.8469;41.1016;2.69961;69.2223;96.7058;3.74981;12.6303;185.32;63.0271;433.686;2.13143;1.97501;2.7438;1.13737;85.7907 4.48599E-12;1158.68;37.9425;1413.32;28.4614;22.9217;2211.2;3428.38;4084.57;161.456;101.065;186.93;185.143;254.163;216.573;124.212;25.2254;496.452;280.185;51.2968;61.9858;299.27;119.986;1425.48;6.02113;37.8319;14.3351;8.23841;236.762 18 11 18 360243;94195;361042;24614;24552;312538;170496;64194;25663;24426;116686;29739;25283;25315;25426;24296;310395;25612 TOP2A_10059;S100A9_9775;PCK2_9440;ORM1_9400;ME1_9215;MCM2_9206;LCN2_32481;INSIG1_8906;IL1R1_8893;GSTP1_8762;GSR_8755;GCLM_8700;GCLC_8699;EPHX1_8567;CYP1B1_32710;CYP1A1_8415;CCRN4L_8232;ASNS_8091 237.5437244444447 79.83054999999999 332.98274605026336 156.95811072222247 52.06435 235.42184823680728 559.4768055555558 154.6775 998.9416611921034 4.48597E-12;963.318;6.67763;662.49;13.1175;3.76863;972.626;37.6554;76.6218;122.514;69.5519;190.233;145.958;27.5708;229.313;83.0393;665.276;6.05608 4.48597E-12;802.143;1.48195;432.445;6.20444;0.956203;551.931;13.2791;27.5215;84.8469;41.1016;69.2223;96.7058;12.6303;185.32;63.0271;433.686;2.7438 4.48599E-12;1158.68;37.9425;1413.32;28.4614;22.9217;4084.57;101.065;185.143;216.573;124.212;496.452;280.185;61.9858;299.27;119.986;1425.48;14.3351 11 59107;24539;116682;29200;360504;24404;24890;54232;81508;24207;25748 LTBP1_33264;LPL_32544;KYNU_8979;INHBA_33300;HBA2_32600;GPX1_33050;ESR1_33192;CAR3_8196;BHMT_8143;APOC3_32553;ALAS2_8019 195.51522363636366 91.8104 321.4645923133544 111.67765727272726 44.1594 177.42004800060732 600.68224 161.456 1134.0481990216385 769.394;900.118;100.381;91.8104;131.05;8.00432;12.5403;3.44933;5.5396;2.87451;125.506 438.027;487.466;72.7231;44.1594;88.5948;2.69961;3.74981;2.13143;1.97501;1.13737;85.7907 2211.2;3428.38;161.456;186.93;254.163;25.2254;51.2968;6.02113;37.8319;8.23841;236.762 0 Exp 2,2(0.07);Exp 4,5(0.18);Exp 5,1(0.04);Hill,10(0.35);Linear,4(0.14);Poly 2,7(0.25) 2.1709074887799917 70.25473630428314 1.5140434503555298 6.759152412414551 1.421203428710447 1.7846373319625854 103.85768905180335 339.3460695688866 62.2390266141293 217.3265060065606 199.39848795807723 950.8144182488196 UP 0.6206896551724138 0.3793103448275862 0.0 GO:0034599 5 cellular response to oxidative stress 95 101 9 9 7 5 4 4 65 97 2381 0.86413 0.29171 0.35068 3.96 287877;170496;116686;25426 pycr1;lcn2;gsr;cyp1b1 PYCR1_9631;LCN2_32481;GSR_8755;CYP1B1_32710 351.039725 180.9905 69.5519 419.566641012012 268.21354704846414 333.6316833229337 217.16775 137.8192 41.1016 231.0633098682913 175.8237807362753 185.49758818750266 1186.9775 269.56399999999996 124.212 1933.095337956115 768.2738305957259 1538.3455436750087 132.668;972.626;69.5519;229.313 90.3184;551.931;41.1016;185.32 239.858;4084.57;124.212;299.27 4 0 4 287877;170496;116686;25426 PYCR1_9631;LCN2_32481;GSR_8755;CYP1B1_32710 351.039725 180.9905 419.566641012012 217.16775 137.8192 231.0633098682913 1186.9775 269.56399999999996 1933.095337956115 132.668;972.626;69.5519;229.313 90.3184;551.931;41.1016;185.32 239.858;4084.57;124.212;299.27 0 0 Exp 4,1(0.25);Linear,2(0.5);Poly 2,1(0.25) 2.0854433373370136 8.618621945381165 1.7646474838256836 3.1843981742858887 0.6875299768034715 1.8347881436347961 -60.13558319177173 762.2150331917717 -9.27429367092546 443.60979367092546 -707.4559311969927 3081.4109311969924 UP 1.0 0.0 0.0 GO:0048522 5 positive regulation of cellular process 1060 1140 58 58 49 31 24 24 45 1116 1362 0.05756 0.96614 0.11012 2.11 360243;192247;94195;361042;24614;259241;316351;24539;170496;64194;29200;25663;360504;24426;24404;25283;25317;24890;24309;25426;24296;310395;25612;24207 top2a;sez6;s100a9;pck2;orm1;nr1d2;npas2;lpl;lcn2;insig1;inhba;il1r1;hba-a2;gstp1;gpx1;gclc;fgf1;esr1;dbp;cyp1b1;cyp1a1;noct;asns;apoc3 TOP2A_10059;SEZ6_9819;S100A9_9775;PCK2_9440;ORM1_9400;NR1D2_9358;NPAS2_9350;LPL_32544;LCN2_32481;INSIG1_8906;INHBA_33300;IL1R1_8893;HBA2_32600;GSTP1_8762;GPX1_33050;GCLC_8699;FGF1_8633;ESR1_33192;DBP_8439;CYP1B1_32710;CYP1A1_8415;CCRN4L_8232;ASNS_8091;APOC3_32553 247.1351437500002 79.83054999999999 4.48597E-12 342.03517029896625 194.45838156760598 296.5605351836219 158.37942958333352 35.84045 4.48597E-12 229.98409216361676 122.83217630809946 190.76879135778094 638.7617712500002 201.04000000000002 4.48599E-12 1076.8302373424742 502.203509976316 940.2762199963319 4.48597E-12;10.6392;963.318;6.67763;662.49;9.46041;53.0014;900.118;972.626;37.6554;91.8104;76.6218;131.05;122.514;8.00432;145.958;674.162;12.5403;66.0377;229.313;83.0393;665.276;6.05608;2.87451 4.48597E-12;3.96047;802.143;1.48195;432.445;2.2133;14.3825;487.466;551.931;13.2791;44.1594;27.5215;88.5948;84.8469;2.69961;96.7058;437.622;3.74981;19.9899;185.32;63.0271;433.686;2.7438;1.13737 4.48599E-12;29.4997;1158.68;37.9425;1413.32;49.4216;215.15;3428.38;4084.57;101.065;186.93;185.143;254.163;216.573;25.2254;280.185;1465.0;51.2968;280.428;299.27;119.986;1425.48;14.3351;8.23841 16 8 16 360243;94195;361042;24614;259241;170496;64194;25663;24426;25283;25317;24309;25426;24296;310395;25612 TOP2A_10059;S100A9_9775;PCK2_9440;ORM1_9400;NR1D2_9358;LCN2_32481;INSIG1_8906;IL1R1_8893;GSTP1_8762;GCLC_8699;FGF1_8633;DBP_8439;CYP1B1_32710;CYP1A1_8415;CCRN4L_8232;ASNS_8091 295.0753325000003 102.77664999999999 358.186655493488 197.18477187500028 73.937 251.49844603423537 695.7124500000002 248.37900000000002 1058.750089907679 4.48597E-12;963.318;6.67763;662.49;9.46041;972.626;37.6554;76.6218;122.514;145.958;674.162;66.0377;229.313;83.0393;665.276;6.05608 4.48597E-12;802.143;1.48195;432.445;2.2133;551.931;13.2791;27.5215;84.8469;96.7058;437.622;19.9899;185.32;63.0271;433.686;2.7438 4.48599E-12;1158.68;37.9425;1413.32;49.4216;4084.57;101.065;185.143;216.573;280.185;1465.0;280.428;299.27;119.986;1425.48;14.3351 8 192247;316351;24539;29200;360504;24404;24890;24207 SEZ6_9819;NPAS2_9350;LPL_32544;INHBA_33300;HBA2_32600;GPX1_33050;ESR1_33192;APOC3_32553 151.25476625000002 32.770849999999996 306.1147225456765 80.768745 9.171485 167.10931204666852 524.86041375 119.1134 1177.1635859853518 10.6392;53.0014;900.118;91.8104;131.05;8.00432;12.5403;2.87451 3.96047;14.3825;487.466;44.1594;88.5948;2.69961;3.74981;1.13737 29.4997;215.15;3428.38;186.93;254.163;25.2254;51.2968;8.23841 0 Exp 2,1(0.05);Exp 4,2(0.09);Exp 5,1(0.05);Hill,10(0.42);Linear,5(0.21);Poly 2,5(0.21) 2.1722994775990756 57.11634826660156 1.5235437154769897 6.292444229125977 1.2523241152354676 1.8208141326904297 110.29257566799242 383.9777118320081 66.36662937284707 250.39222979381998 207.93994980543647 1069.583592694564 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0002684 5 positive regulation of immune system process 239 264 8 8 6 5 3 3 66 261 2217 0.061331 0.97999 0.10931 1.14 29200;25663;117517 inhba;il1r1;c7 INHBA_33300;IL1R1_8893;C7_8179 90.7634 91.8104 76.6218 13.648252795138166 94.17492181056525 13.874564050728978 34.8041 32.7314 27.5215 8.510404988600731 34.00355681954191 7.247087723070176 221.95133333333334 186.93 185.143 62.21273263837006 241.78056955551932 65.97425831416484 91.8104;76.6218;103.858 44.1594;27.5215;32.7314 186.93;185.143;293.781 1 2 1 25663 IL1R1_8893 76.6218 76.6218 27.5215 27.5215 185.143 185.143 76.6218 27.5215 185.143 2 29200;117517 INHBA_33300;C7_8179 97.83420000000001 97.83420000000001 8.518939657022916 38.4454 38.4454 8.080816295399856 240.3555 240.3555 75.55506667656384 91.8104;103.858 44.1594;32.7314 186.93;293.781 0 Hill,3(1) 1.9569610246185583 5.916466116905212 1.6931662559509277 2.2924909591674805 0.30179409029905463 1.9308089017868042 75.31894804652734 106.20785195347267 25.173670162280537 44.43452983771946 151.55099897919422 292.35166768747246 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0032642 6 regulation of chemokine production 31 34 4 4 3 3 2 2 67 32 2446 0.93739 0.23454 0.23454 5.88 24539;24426 lpl;gstp1 LPL_32544;GSTP1_8762 511.31600000000003 511.31600000000003 122.514 549.8490614777842 689.6141560624249 488.6241147318443 286.15645 286.15645 84.8469 284.6946958452247 378.4736746098439 252.9943278476344 1822.4765 1822.4765 216.573 2271.090509562422 2558.9172406962784 2018.207663623823 0.5 511.31600000000003 900.118;122.514 487.466;84.8469 3428.38;216.573 1 1 1 24426 GSTP1_8762 122.514 122.514 84.8469 84.8469 216.573 216.573 122.514 84.8469 216.573 1 24539 LPL_32544 900.118 900.118 487.466 487.466 3428.38 3428.38 900.118 487.466 3428.38 0 Exp 2,1(0.5);Poly 2,1(0.5) 3.064639622472878 7.216514706611633 1.7036563158035278 5.5128583908081055 2.6935126181456046 3.6082573533058167 -250.73591999999985 1273.36792 -108.41026800000003 680.723168 -1325.0943600000007 4970.0473600000005 CONFLICT 0.5 0.5 0.0 GO:0017144 4 drug metabolic process 142 165 19 19 16 16 13 13 56 152 2326 0.99991 3.5022E-4 3.5022E-4 7.88 287877;58835;361042;287167;116682;360504;84029;24404;25426;24296;81508;25612;296925 pycr1;phgdh;pck2;hba-a1;kynu;hba-a2;hao2;gpx1;cyp1b1;cyp1a1;bhmt;asns;aass PYCR1_9631;PHGDH_9470;PCK2_9440;LOC287167_9118;KYNU_8979;HBA2_32600;HAO2_8778;GPX1_33050;CYP1B1_32710;CYP1A1_8415;BHMT_8143;ASNS_8091;AASS_7936 86.26951461538462 100.381 5.5396 73.5986791348926 90.04998371425376 77.64770795476734 59.206981538461534 67.6778 1.48195 55.38031161808347 63.15096196098379 59.958324929867096 159.05231538461535 161.456 14.0792 122.35338054993859 160.7599714019005 122.59545483164149 7.5 126.938 132.668;122.826;6.67763;149.282;100.381;131.05;140.856;8.00432;229.313;83.0393;5.5396;6.05608;5.81076 90.3184;67.6778;1.48195;97.0024;72.7231;88.5948;93.5219;2.69961;185.32;63.0271;1.97501;2.7438;2.60489 239.858;246.456;37.9425;334.152;161.456;254.163;282.925;25.2254;299.27;119.986;37.8319;14.3351;14.0792 6 7 6 287877;58835;361042;25426;24296;25612 PYCR1_9631;PHGDH_9470;PCK2_9440;CYP1B1_32710;CYP1A1_8415;ASNS_8091 96.763335 102.93265 84.93457559667904 68.428175 65.35245 67.77735541767434 159.64126666666667 179.922 119.1341407461634 132.668;122.826;6.67763;229.313;83.0393;6.05608 90.3184;67.6778;1.48195;185.32;63.0271;2.7438 239.858;246.456;37.9425;299.27;119.986;14.3351 7 287167;116682;360504;84029;24404;81508;296925 LOC287167_9118;KYNU_8979;HBA2_32600;HAO2_8778;GPX1_33050;BHMT_8143;AASS_7936 77.27481142857143 100.381 67.9518478904377 51.30310142857143 72.7231 46.34547037063472 158.54749999999999 161.456 134.58306869467893 149.282;100.381;131.05;140.856;8.00432;5.5396;5.81076 97.0024;72.7231;88.5948;93.5219;2.69961;1.97501;2.60489 334.152;161.456;254.163;282.925;25.2254;37.8319;14.0792 0 Exp 4,2(0.16);Hill,4(0.31);Linear,1(0.08);Poly 2,6(0.47) 2.230805757895897 31.672714710235596 1.528982162475586 6.292444229125977 1.3030954344314587 1.948032259941101 46.26081689250287 126.2782123382664 29.101901211327604 89.31206186559547 92.54026006874176 225.564370700489 CONFLICT 0.46153846153846156 0.5384615384615384 0.0 GO:0071103 7 DNA conformation change 30 32 4 4 4 3 3 3 66 29 2449 0.98999 0.053907 0.053907 9.38 360243;29685;312538 top2a;mcm6;mcm2 TOP2A_10059;MCM6_9210;MCM2_9206 1.8810133333348287 1.87441 4.48597E-12 1.8843236776692307 1.760683246097648 1.666659598272627 0.48435333333482866 0.496857 4.48597E-12 0.478224111228366 0.45681751660567554 0.4241069207247885 10.817233333334828 9.53 4.48599E-12 11.514938556643925 9.821928392347923 10.110749147381817 0.5 0.9372050000022429 4.48597E-12;1.87441;3.76863 4.48597E-12;0.496857;0.956203 4.48599E-12;9.53;22.9217 3 0 3 360243;29685;312538 TOP2A_10059;MCM6_9210;MCM2_9206 1.8810133333348287 1.87441 1.8843236776692307 0.48435333333482866 0.496857 0.478224111228366 10.817233333334828 9.53 11.514938556643925 4.48597E-12;1.87441;3.76863 4.48597E-12;0.496857;0.956203 4.48599E-12;9.53;22.9217 0 0 Hill,3(1) 1.695978411673296 5.102184057235718 1.5280487537384033 1.8211764097213745 0.1533851488223578 1.75295889377594 -0.25129964044889475 4.013326307118552 -0.056808192592477935 1.0255148592621353 -2.2131463024106974 23.84761296908036 UP 1.0 0.0 0.0 GO:0045862 8 positive regulation of proteolysis 112 119 7 7 4 5 2 2 67 117 2361 0.36548 0.84246 0.76996 1.68 94195;25283 s100a9;gclc S100A9_9775;GCLC_8699 554.638 554.638 145.958 577.9607986706363 357.5014181169121 506.2736621303789 449.4244 449.4244 96.7058 498.8194278212508 279.282139134315 436.948559566165 719.4325 719.4325 280.185 621.1897717384762 507.5509526996877 544.1407468107411 963.318;145.958 802.143;96.7058 1158.68;280.185 2 0 2 94195;25283 S100A9_9775;GCLC_8699 554.638 554.638 577.9607986706363 449.4244 449.4244 498.8194278212508 719.4325 719.4325 621.1897717384762 963.318;145.958 802.143;96.7058 1158.68;280.185 0 0 Poly 2,2(1) 1.732778503807397 3.465989112854004 1.7056305408477783 1.7603585720062256 0.03869856195312672 1.732994556427002 -246.37479999999994 1355.6508 -241.90405599999997 1140.752856 -141.49259999999992 1580.3575999999998 UP 1.0 0.0 0.0 GO:0048518 4 positive regulation of biological process 1152 1238 63 63 54 33 26 26 43 1212 1266 0.042287 0.97573 0.068029 2.1 360243;192247;94195;361042;24614;259241;316351;59107;24539;170496;64194;29200;25663;360504;24426;24404;25283;25317;24890;24309;25426;24296;310395;117517;25612;24207 top2a;sez6;s100a9;pck2;orm1;nr1d2;npas2;ltbp1;lpl;lcn2;insig1;inhba;il1r1;hba-a2;gstp1;gpx1;gclc;fgf1;esr1;dbp;cyp1b1;cyp1a1;noct;c7;asns;apoc3 TOP2A_10059;SEZ6_9819;S100A9_9775;PCK2_9440;ORM1_9400;NR1D2_9358;NPAS2_9350;LTBP1_33264;LPL_32544;LCN2_32481;INSIG1_8906;INHBA_33300;IL1R1_8893;HBA2_32600;GSTP1_8762;GPX1_33050;GCLC_8699;FGF1_8633;ESR1_33192;DBP_8439;CYP1B1_32710;CYP1A1_8415;CCRN4L_8232;C7_8179;ASNS_8091;APOC3_32553 261.71136346153867 87.42484999999999 4.48597E-12 345.16569121150184 195.10053205483808 292.3282878640504 164.302488846154 38.4454 4.48597E-12 228.8763634351738 120.59216846213991 187.70826078555208 685.9716734615387 215.8615 4.48599E-12 1080.806788477856 508.015784799092 922.8946683281943 4.48597E-12;10.6392;963.318;6.67763;662.49;9.46041;53.0014;769.394;900.118;972.626;37.6554;91.8104;76.6218;131.05;122.514;8.00432;145.958;674.162;12.5403;66.0377;229.313;83.0393;665.276;103.858;6.05608;2.87451 4.48597E-12;3.96047;802.143;1.48195;432.445;2.2133;14.3825;438.027;487.466;551.931;13.2791;44.1594;27.5215;88.5948;84.8469;2.69961;96.7058;437.622;3.74981;19.9899;185.32;63.0271;433.686;32.7314;2.7438;1.13737 4.48599E-12;29.4997;1158.68;37.9425;1413.32;49.4216;215.15;2211.2;3428.38;4084.57;101.065;186.93;185.143;254.163;216.573;25.2254;280.185;1465.0;51.2968;280.428;299.27;119.986;1425.48;293.781;14.3351;8.23841 16 10 16 360243;94195;361042;24614;259241;170496;64194;25663;24426;25283;25317;24309;25426;24296;310395;25612 TOP2A_10059;S100A9_9775;PCK2_9440;ORM1_9400;NR1D2_9358;LCN2_32481;INSIG1_8906;IL1R1_8893;GSTP1_8762;GCLC_8699;FGF1_8633;DBP_8439;CYP1B1_32710;CYP1A1_8415;CCRN4L_8232;ASNS_8091 295.0753325000003 102.77664999999999 358.186655493488 197.18477187500028 73.937 251.49844603423537 695.7124500000002 248.37900000000002 1058.750089907679 4.48597E-12;963.318;6.67763;662.49;9.46041;972.626;37.6554;76.6218;122.514;145.958;674.162;66.0377;229.313;83.0393;665.276;6.05608 4.48597E-12;802.143;1.48195;432.445;2.2133;551.931;13.2791;27.5215;84.8469;96.7058;437.622;19.9899;185.32;63.0271;433.686;2.7438 4.48599E-12;1158.68;37.9425;1413.32;49.4216;4084.57;101.065;185.143;216.573;280.185;1465.0;280.428;299.27;119.986;1425.48;14.3351 10 192247;316351;59107;24539;29200;360504;24404;24890;117517;24207 SEZ6_9819;NPAS2_9350;LTBP1_33264;LPL_32544;INHBA_33300;HBA2_32600;GPX1_33050;ESR1_33192;C7_8179;APOC3_32553 208.32901299999997 72.4059 334.6161038904983 111.69083599999999 23.55695 187.3374689256284 670.386431 201.04000000000002 1173.0946459796764 10.6392;53.0014;769.394;900.118;91.8104;131.05;8.00432;12.5403;103.858;2.87451 3.96047;14.3825;438.027;487.466;44.1594;88.5948;2.69961;3.74981;32.7314;1.13737 29.4997;215.15;2211.2;3428.38;186.93;254.163;25.2254;51.2968;293.781;8.23841 0 Exp 2,2(0.08);Exp 4,2(0.08);Exp 5,1(0.04);Hill,11(0.43);Linear,5(0.2);Poly 2,5(0.2) 2.1326577653336765 60.5612006187439 1.5140434503555298 6.292444229125977 1.2158292852855208 1.8208141326904297 129.03394322984744 394.3887836932299 76.32524711623223 252.27973057607585 270.5229190942544 1101.4204278288228 UP 0.6153846153846154 0.38461538461538464 0.0 GO:0051051 5 negative regulation of transport 140 146 11 11 9 7 5 5 64 141 2337 0.79936 0.36181 0.59398 3.42 64194;25283;24890;24207;114628 insig1;gclc;esr1;apoc3;abcg5 INSIG1_8906;GCLC_8699;ESR1_33192;APOC3_32553;ABCG5_7947 152.878242 37.6554 2.87451 237.5203813512313 180.61150059671903 265.8321936591025 100.344616 13.2791 1.13737 164.96377430822938 120.18660676272476 184.14517897182498 297.745042 101.065 8.23841 431.9533235668119 346.5251910388941 484.94426410552273 37.6554;145.958;12.5403;2.87451;565.363 13.2791;96.7058;3.74981;1.13737;386.851 101.065;280.185;51.2968;8.23841;1047.94 2 3 2 64194;25283 INSIG1_8906;GCLC_8699 91.8067 91.8067 76.5815028801342 54.99245 54.99245 58.991585302015736 190.625 190.625 126.6569666461344 37.6554;145.958 13.2791;96.7058 101.065;280.185 3 24890;24207;114628 ESR1_33192;APOC3_32553;ABCG5_7947 193.59260333333336 12.5403 321.9988784954834 130.57939333333334 3.74981 221.94156550390562 369.15840333333335 51.2968 588.236218042854 12.5403;2.87451;565.363 3.74981;1.13737;386.851 51.2968;8.23841;1047.94 0 Exp 4,1(0.2);Exp 5,1(0.2);Hill,1(0.2);Linear,1(0.2);Poly 2,1(0.2) 1.7474010673394686 8.765876770019531 1.5235437154769897 1.9665359258651733 0.15786347486792235 1.7603585720062256 -55.31755174726635 361.07403574726635 -44.252507565828594 244.94173956582858 -80.87873988412241 676.3688238841224 DOWN 0.4 0.6 0.0 GO:0009891 6 positive regulation of biosynthetic process 418 451 21 21 19 13 11 11 58 440 2038 0.4216 0.70036 0.8728 2.44 360243;259241;316351;59107;64194;29200;25317;24890;24309;25426;24207 top2a;nr1d2;npas2;ltbp1;insig1;inhba;fgf1;esr1;dbp;cyp1b1;apoc3 TOP2A_10059;NR1D2_9358;NPAS2_9350;LTBP1_33264;INSIG1_8906;INHBA_33300;FGF1_8633;ESR1_33192;DBP_8439;CYP1B1_32710;APOC3_32553 176.9317381818186 53.0014 4.48597E-12 277.84257555715476 145.22863175558925 238.17224798029733 105.44367090909132 14.3825 4.48597E-12 172.6775080391887 91.80657892408028 156.29946787579615 442.5454372727277 186.93 4.48599E-12 717.3639202514383 326.94125813185923 546.4718154136345 4.48597E-12;9.46041;53.0014;769.394;37.6554;91.8104;674.162;12.5403;66.0377;229.313;2.87451 4.48597E-12;2.2133;14.3825;438.027;13.2791;44.1594;437.622;3.74981;19.9899;185.32;1.13737 4.48599E-12;49.4216;215.15;2211.2;101.065;186.93;1465.0;51.2968;280.428;299.27;8.23841 6 5 6 360243;259241;64194;25317;24309;25426 TOP2A_10059;NR1D2_9358;INSIG1_8906;FGF1_8633;DBP_8439;CYP1B1_32710 169.43808500000077 51.84655 261.0332057995738 109.73738333333408 16.6345 175.60386486329242 365.86410000000075 190.7465 552.0769487748419 4.48597E-12;9.46041;37.6554;674.162;66.0377;229.313 4.48597E-12;2.2133;13.2791;437.622;19.9899;185.32 4.48599E-12;49.4216;101.065;1465.0;280.428;299.27 5 316351;59107;29200;24890;24207 NPAS2_9350;LTBP1_33264;INHBA_33300;ESR1_33192;APOC3_32553 185.92412199999998 53.0014 328.07470620675554 100.29121599999999 14.3825 189.57074952070647 534.563042 186.93 941.348605874585 53.0014;769.394;91.8104;12.5403;2.87451 14.3825;438.027;44.1594;3.74981;1.13737 215.15;2211.2;186.93;51.2968;8.23841 0 Exp 2,1(0.1);Exp 4,2(0.19);Exp 5,1(0.1);Hill,5(0.46);Linear,2(0.19) 1.969269250273434 22.25716197490692 1.5140434503555298 3.1843981742858887 0.5211696325176225 1.9026079177856445 12.737268648932854 341.1262077147044 3.3977847597139146 207.48955705846873 18.610451385417605 866.4804231600378 CONFLICT 0.5454545454545454 0.45454545454545453 0.0 GO:0010212 5 response to ionizing radiation 75 76 9 9 8 4 3 3 66 73 2405 0.85153 0.33958 0.45972 3.95 360243;24404;114628 top2a;gpx1;abcg5 TOP2A_10059;GPX1_33050;ABCG5_7947 191.1224400000015 8.00432 4.48597E-12 324.1265414101413 265.98360736465605 342.8732539222268 129.85020333333483 2.69961 4.48597E-12 222.57331171776516 181.2184411999823 235.49715837036507 357.72180000000156 25.2254 4.48599E-12 597.8795471578858 495.9424571980051 632.2578090073623 4.48597E-12;8.00432;565.363 4.48597E-12;2.69961;386.851 4.48599E-12;25.2254;1047.94 1 2 1 360243 TOP2A_10059 4.48597E-12 4.48597E-12 4.48597E-12 4.48597E-12 4.48599E-12 4.48599E-12 4.48597E-12 4.48597E-12 4.48599E-12 2 24404;114628 GPX1_33050;ABCG5_7947 286.68366000000003 286.68366000000003 394.11210218118305 194.775305 194.775305 271.6360528712381 536.5827 536.5827 723.1684288784876 8.00432;565.363 2.69961;386.851 25.2254;1047.94 0 Hill,2(0.67);Linear,1(0.34) 1.773663170539453 5.321172714233398 1.75295889377594 1.7846373319625854 0.01799113643427854 1.783576488494873 -175.6612700319074 557.9061500319104 -122.01520907863446 381.71561574530415 -318.84259828936933 1034.2861982893724 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0051128 5 regulation of cellular component organization 515 547 29 29 27 13 12 12 57 535 1943 0.25003 0.83803 0.45991 2.19 360243;192247;94195;312538;287598;170496;64194;29200;24404;25283;24890;24207 top2a;sez6;s100a9;mcm2;ska2;lcn2;insig1;inhba;gpx1;gclc;esr1;apoc3 TOP2A_10059;SEZ6_9819;S100A9_9775;MCM2_9206;LOC691962_32591;LCN2_32481;INSIG1_8906;INHBA_33300;GPX1_33050;GCLC_8699;ESR1_33192;APOC3_32553 187.63899000000038 11.58975 4.48597E-12 367.1754766499652 114.88929341736507 289.10687471503525 126.79435466666705 3.85514 4.48597E-12 264.0003131351755 71.25089960464413 191.19621205962878 496.5829841666671 40.39825 4.48599E-12 1175.3380601694478 355.66692319282134 1048.9554908354555 4.48597E-12;10.6392;963.318;3.76863;2.47312;972.626;37.6554;91.8104;8.00432;145.958;12.5403;2.87451 4.48597E-12;3.96047;802.143;0.956203;0.810493;551.931;13.2791;44.1594;2.69961;96.7058;3.74981;1.13737 4.48599E-12;29.4997;1158.68;22.9217;10.3838;4084.57;101.065;186.93;25.2254;280.185;51.2968;8.23841 7 5 7 360243;94195;312538;287598;170496;64194;25283 TOP2A_10059;S100A9_9775;MCM2_9206;LOC691962_32591;LCN2_32481;INSIG1_8906;GCLC_8699 303.6855928571435 37.6554 456.645434234777 209.40365657142925 13.2791 329.3027732915751 808.2579285714293 101.065 1502.3668143795248 4.48597E-12;963.318;3.76863;2.47312;972.626;37.6554;145.958 4.48597E-12;802.143;0.956203;0.810493;551.931;13.2791;96.7058 4.48599E-12;1158.68;22.9217;10.3838;4084.57;101.065;280.185 5 192247;29200;24404;24890;24207 SEZ6_9819;INHBA_33300;GPX1_33050;ESR1_33192;APOC3_32553 25.173746 10.6392 37.42774958813955 11.141332 3.74981 18.49144475842058 60.238062 29.4997 72.46635517127739 10.6392;91.8104;8.00432;12.5403;2.87451 3.96047;44.1594;2.69961;3.74981;1.13737 29.4997;186.93;25.2254;51.2968;8.23841 0 Exp 4,2(0.17);Exp 5,1(0.09);Hill,6(0.5);Linear,1(0.09);Poly 2,2(0.17) 1.866383327907359 23.15431237220764 1.503517508506775 3.747737169265747 0.6121305425206137 1.7566587328910828 -20.110093078012454 395.38807307801324 -22.577884150977212 276.1665934843113 -168.42712635242333 1161.5930946857575 CONFLICT 0.5833333333333334 0.4166666666666667 0.0 GO:0006875 8 cellular metal ion homeostasis 132 139 6 6 5 6 5 5 64 134 2344 0.82839 0.32332 0.42384 3.6 24567;288001;24890;117517;25748 mt1;kng1;esr1;c7;alas2 MT1A_9255;KNG1L1_32433;ESR1_33192;C7_8179;ALAS2_8019 288001(0.1788) 212.822772 103.858 3.87556 342.75114640092147 104.35230395310022 200.49610744140895 132.748604 32.7314 1.25511 230.30924453050844 53.9460862252168 134.57412321238357 316.83444 236.762 13.8374 393.82369440792667 212.51361218092254 248.99650364525462 818.334;3.87556;12.5403;103.858;125.506 540.216;1.25511;3.74981;32.7314;85.7907 988.495;13.8374;51.2968;293.781;236.762 1 4 1 288001 KNG1L1_32433 3.87556 3.87556 1.25511 1.25511 13.8374 13.8374 3.87556 1.25511 13.8374 4 24567;24890;117517;25748 MT1A_9255;ESR1_33192;C7_8179;ALAS2_8019 265.059575 114.682 372.08409519147125 165.6219775 59.26105 252.02924351448058 392.5837 265.2715 410.54005135409955 818.334;12.5403;103.858;125.506 540.216;3.74981;32.7314;85.7907 988.495;51.2968;293.781;236.762 0 Exp 4,1(0.2);Hill,2(0.4);Poly 2,2(0.4) 1.8497427857734017 9.334048390388489 1.5755720138549805 2.3371741771698 0.29157823730506727 1.7586312294006348 -87.61185418562954 513.2573981856295 -69.12634963380071 334.62355763380066 -28.367248323721242 662.0361283237213 DOWN 0.2 0.8 0.0 GO:0021960 12 anterior commissure morphogenesis 1 1 1 1 1 1 1 1 68 0 2478 1.0 0.027091 0.027091 100.0 308843 tsku TSKU_10094 92.2997 92.2997 92.2997 92.29970000000002 49.0864 49.0864 49.0864 49.0864 185.899 185.899 185.899 185.899 0.0 92.2997 0.0 92.2997 92.2997 49.0864 185.899 1 0 1 308843 TSKU_10094 92.2997 92.2997 49.0864 49.0864 185.899 185.899 92.2997 49.0864 185.899 0 0 Exp 4,1(1) 3.334043025970459 3.334043025970459 3.334043025970459 3.334043025970459 0.0 3.334043025970459 92.2997 92.2997 49.0864 49.0864 185.899 185.899 UP 1.0 0.0 0.0 GO:0051240 5 positive regulation of multicellular organismal process 484 516 22 22 18 14 10 10 59 506 1972 0.14428 0.91781 0.28729 1.94 192247;94195;24614;316351;24539;170496;29200;25663;25317;25426 sez6;s100a9;orm1;npas2;lpl;lcn2;inhba;il1r1;fgf1;cyp1b1 SEZ6_9819;S100A9_9775;ORM1_9400;NPAS2_9350;LPL_32544;LCN2_32481;INHBA_33300;IL1R1_8893;FGF1_8633;CYP1B1_32710 463.40998 445.9015 10.6392 408.23488178620846 428.25545710914986 372.6124772561894 298.695087 308.8825 3.96047 280.7315829311189 273.1945416428068 236.73650953049454 1246.59427 728.975 29.4997 1437.1928493954517 1156.916230616875 1394.3920940817331 10.6392;963.318;662.49;53.0014;900.118;972.626;91.8104;76.6218;674.162;229.313 3.96047;802.143;432.445;14.3825;487.466;551.931;44.1594;27.5215;437.622;185.32 29.4997;1158.68;1413.32;215.15;3428.38;4084.57;186.93;185.143;1465.0;299.27 6 4 6 94195;24614;170496;25663;25317;25426 S100A9_9775;ORM1_9400;LCN2_32481;IL1R1_8893;FGF1_8633;CYP1B1_32710 596.4218000000001 668.326 371.8902737251404 406.16375 435.0335 272.7159322800467 1434.3305 1286.0 1410.671217092594 963.318;662.49;972.626;76.6218;674.162;229.313 802.143;432.445;551.931;27.5215;437.622;185.32 1158.68;1413.32;4084.57;185.143;1465.0;299.27 4 192247;316351;24539;29200 SEZ6_9819;NPAS2_9350;LPL_32544;INHBA_33300 263.89225 72.4059 425.4438568563856 137.4920925 29.27095 233.93688136839864 964.9899250000001 201.04000000000002 1644.290098359985 10.6392;53.0014;900.118;91.8104 3.96047;14.3825;487.466;44.1594 29.4997;215.15;3428.38;186.93 0 Exp 2,1(0.1);Hill,4(0.4);Linear,4(0.4);Poly 2,1(0.1) 2.0920416895501446 21.9445698261261 1.5487829446792603 3.747737169265747 0.7640012383048437 1.7813107371330261 210.3833788322948 716.4365811677051 124.6958492114704 472.6943247885297 355.81291316459306 2137.3756268354073 UP 0.6 0.4 0.0 GO:0070555 6 response to interleukin-1 63 66 4 4 3 4 3 3 66 63 2415 0.89848 0.26449 0.42386 4.55 170496;25663;25283 lcn2;il1r1;gclc LCN2_32481;IL1R1_8893;GCLC_8699 398.4019333333333 145.958 76.6218 498.49958496674134 368.3197934316645 482.9945321254421 225.38610000000003 96.7058 27.5215 284.9040112540187 208.60137135072293 275.95456669746955 1516.6326666666666 280.185 185.143 2224.4066301794583 1379.7770079197849 2156.4993129027134 972.626;76.6218;145.958 551.931;27.5215;96.7058 4084.57;185.143;280.185 3 0 3 170496;25663;25283 LCN2_32481;IL1R1_8893;GCLC_8699 398.4019333333333 145.958 498.49958496674134 225.38610000000003 96.7058 284.9040112540187 1516.6326666666666 280.185 2224.4066301794583 972.626;76.6218;145.958 551.931;27.5215;96.7058 4084.57;185.143;280.185 0 0 Hill,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 1.7689009252987897 5.310515761375427 1.6931662559509277 1.856990933418274 0.08235203453894725 1.7603585720062256 -165.70345102673758 962.5073176934043 -97.01313887779526 547.7853388777953 -1000.5203961070788 4033.7857294404116 UP 1.0 0.0 0.0 GO:0031327 7 negative regulation of cellular biosynthetic process 281 294 14 14 10 8 5 5 64 289 2189 0.17415 0.9149 0.33918 1.7 259241;64194;25283;24890;24207 nr1d2;insig1;gclc;esr1;apoc3 NR1D2_9358;INSIG1_8906;GCLC_8699;ESR1_33192;APOC3_32553 41.697724 12.5403 2.87451 59.75614459714022 31.10525235281273 52.44830359076073 23.417076 3.74981 1.13737 41.251673877989845 16.73867705297923 35.75783225871862 98.041362 51.2968 8.23841 107.00344944446051 77.92942512951387 95.50335232814196 9.46041;37.6554;145.958;12.5403;2.87451 2.2133;13.2791;96.7058;3.74981;1.13737 49.4216;101.065;280.185;51.2968;8.23841 3 2 3 259241;64194;25283 NR1D2_9358;INSIG1_8906;GCLC_8699 64.35793666666666 37.6554 72.060163178264 37.3994 13.2791 51.658008025184245 143.5572 101.065 121.10791464854805 9.46041;37.6554;145.958 2.2133;13.2791;96.7058 49.4216;101.065;280.185 2 24890;24207 ESR1_33192;APOC3_32553 7.707405 7.707405 6.834745654525119 2.44359 2.44359 1.847274039442984 29.767605 29.767605 30.446879555975023 12.5403;2.87451 3.74981;1.13737 51.2968;8.23841 0 Exp 4,1(0.2);Exp 5,1(0.2);Hill,2(0.4);Poly 2,1(0.2) 1.8184698619630248 9.15930461883545 1.5235437154769897 2.177004337310791 0.24871328395228823 1.7603585720062256 -10.680846145864827 94.07629414586481 -12.741610414920359 59.57576241492036 4.248703180367883 191.83402081963214 UP 0.6 0.4 0.0 GO:0036316 10 SREBP-SCAP complex retention in endoplasmic reticulum 1 1 1 1 1 1 1 1 68 0 2478 1.0 0.027091 0.027091 100.0 64194 insig1 INSIG1_8906 37.6554 37.6554 37.6554 37.6554 13.2791 13.2791 13.2791 13.2791 101.065 101.065 101.065 101.065 0.0 37.6554 0.0 37.6554 37.6554 13.2791 101.065 1 0 1 64194 INSIG1_8906 37.6554 37.6554 13.2791 13.2791 101.065 101.065 37.6554 13.2791 101.065 0 0 Exp 5,1(1) 1.9665359258651733 1.9665359258651733 1.9665359258651733 1.9665359258651733 0.0 1.9665359258651733 37.6554 37.6554 13.2791 13.2791 101.065 101.065 UP 1.0 0.0 0.0 GO:0097306 6 cellular response to alcohol 47 52 4 4 4 2 2 2 67 50 2428 0.83496 0.41448 0.65073 3.85 29200;25426 inhba;cyp1b1 INHBA_33300;CYP1B1_32710 160.5617 160.5617 91.8104 97.22902089078134 188.66293120316695 88.7362615457306 114.7397 114.7397 44.1594 99.81561749636174 143.58851200339316 91.09692414217821 243.1 243.1 186.93 79.43637579849673 266.05878269475465 72.497768202546 91.8104;229.313 44.1594;185.32 186.93;299.27 1 1 1 25426 CYP1B1_32710 229.313 229.313 185.32 185.32 299.27 299.27 229.313 185.32 299.27 1 29200 INHBA_33300 91.8104 91.8104 44.1594 44.1594 186.93 186.93 91.8104 44.1594 186.93 0 Hill,1(0.5);Linear,1(0.5) 2.701888973466495 5.476889133453369 2.2924909591674805 3.1843981742858887 0.6306736399994353 2.7384445667266846 25.80915200000001 295.3142479999999 -23.597687999999977 253.07708799999997 133.00680000000006 353.19319999999993 CONFLICT 0.5 0.5 0.0 GO:0042745 5 circadian sleep/wake cycle 2 2 1 1 1 1 1 1 68 1 2477 0.99928 0.053458 0.053458 50.0 316351 npas2 NPAS2_9350 53.0014 53.0014 53.0014 53.0014 14.3825 14.3825 14.3825 14.3825 215.15 215.15 215.15 215.15 0.0 53.0014 0.0 53.0014 53.0014 14.3825 215.15 0 1 0 1 316351 NPAS2_9350 53.0014 53.0014 14.3825 14.3825 215.15 215.15 53.0014 14.3825 215.15 0 Hill,1(1) 2.6413023471832275 2.6413023471832275 2.6413023471832275 2.6413023471832275 0.0 2.6413023471832275 53.0014 53.0014 14.3825 14.3825 215.15 215.15 DOWN 0.0 1.0 0.0 GO:0070542 5 response to fatty acid 60 63 6 6 5 5 4 4 65 59 2419 0.97372 0.08903 0.08903 6.35 24539;64194;24207;25748 lpl;insig1;apoc3;alas2 LPL_32544;INSIG1_8906;APOC3_32553;ALAS2_8019 266.5384775 81.58070000000001 2.87451 425.52685851965845 176.15134343161233 374.49052892833896 146.9182925 49.5349 1.13737 230.08754477760175 95.77355463722827 203.5670424174404 943.6113525000001 168.9135 8.23841 1659.1682792291656 626.83946388904 1441.060858819999 2.5 512.812 900.118;37.6554;2.87451;125.506 487.466;13.2791;1.13737;85.7907 3428.38;101.065;8.23841;236.762 1 3 1 64194 INSIG1_8906 37.6554 37.6554 13.2791 13.2791 101.065 101.065 37.6554 13.2791 101.065 3 24539;24207;25748 LPL_32544;APOC3_32553;ALAS2_8019 342.8328366666667 125.506 486.50250311637666 191.46469000000002 85.7907 259.8155657602317 1224.4601366666668 236.762 1912.067684678823 900.118;2.87451;125.506 487.466;1.13737;85.7907 3428.38;8.23841;236.762 0 Exp 2,1(0.25);Exp 4,1(0.25);Exp 5,1(0.25);Poly 2,1(0.25) 1.7309255692041348 6.952367186546326 1.5235437154769897 1.9665359258651733 0.18241461011182283 1.7311437726020813 -150.4778438492653 683.5547988492654 -78.56750138204976 372.40408638204974 -682.3735611445825 2569.596266144582 DOWN 0.25 0.75 0.0 GO:0045597 6 positive regulation of cell differentiation 285 303 16 16 14 8 6 6 63 297 2181 0.26889 0.84761 0.57001 1.98 192247;94195;24539;29200;25663;310395 sez6;s100a9;lpl;inhba;il1r1;noct SEZ6_9819;S100A9_9775;LPL_32544;INHBA_33300;IL1R1_8893;CCRN4L_8232 451.2972333333334 378.54319999999996 10.6392 441.1766595589828 401.86601448855635 407.53197676050394 299.8227283333333 238.9227 3.96047 326.343745318573 252.22960407827523 279.3032337552283 1069.0187833333332 672.8050000000001 29.4997 1291.6350901188935 1021.0286435340494 1253.248865055591 10.6392;963.318;900.118;91.8104;76.6218;665.276 3.96047;802.143;487.466;44.1594;27.5215;433.686 29.4997;1158.68;3428.38;186.93;185.143;1425.48 3 3 3 94195;25663;310395 S100A9_9775;IL1R1_8893;CCRN4L_8232 568.4052666666666 665.276 451.2155715464764 421.1168333333333 433.686 387.46368220593695 923.101 1158.68 652.8645091617403 963.318;76.6218;665.276 802.143;27.5215;433.686 1158.68;185.143;1425.48 3 192247;24539;29200 SEZ6_9819;LPL_32544;INHBA_33300 334.1892 91.8104 491.7862807454474 178.52862333333334 44.1594 268.30153842188014 1214.9365666666667 186.93 1918.5137344476746 10.6392;900.118;91.8104 3.96047;487.466;44.1594 29.4997;3428.38;186.93 0 Exp 2,1(0.17);Hill,3(0.5);Linear,1(0.17);Poly 2,1(0.17) 2.050329080850078 12.900192499160767 1.6931662559509277 3.747737169265747 0.8163944037254782 1.7315708994865417 98.28238390060892 804.3120827660578 38.69334711876513 560.9521095479015 35.49546114274858 2102.5421055239185 CONFLICT 0.5 0.5 0.0 GO:0071496 4 cellular response to external stimulus 143 149 11 11 9 8 6 6 63 143 2335 0.89474 0.21363 0.29337 4.03 59107;24539;170496;24426;25283;25612 ltbp1;lpl;lcn2;gstp1;gclc;asns LTBP1_33264;LPL_32544;LCN2_32481;GSTP1_8762;GCLC_8699;ASNS_8091 486.11101333333335 457.676 6.05608 439.70614446405125 494.4567277453081 452.3979588229301 276.95341666666667 267.3664 2.7438 241.0219696449469 280.8439971509227 248.02785950589157 1705.87385 1245.6924999999999 14.3351 1788.434309124217 1810.9759889591721 1891.330413769134 769.394;900.118;972.626;122.514;145.958;6.05608 438.027;487.466;551.931;84.8469;96.7058;2.7438 2211.2;3428.38;4084.57;216.573;280.185;14.3351 4 2 4 170496;24426;25283;25612 LCN2_32481;GSTP1_8762;GCLC_8699;ASNS_8091 311.78852 134.236 444.78575558943913 184.056875 90.77635000000001 248.78279177737056 1148.915775 248.37900000000002 1960.382211574281 972.626;122.514;145.958;6.05608 551.931;84.8469;96.7058;2.7438 4084.57;216.573;280.185;14.3351 2 59107;24539 LTBP1_33264;LPL_32544 834.7560000000001 834.7560000000001 92.43582686382874 462.74649999999997 462.74649999999997 34.958652155082945 2819.79 2819.79 860.6762319246413 769.394;900.118 438.027;487.466 2211.2;3428.38 0 Exp 2,2(0.34);Hill,1(0.17);Linear,1(0.17);Poly 2,2(0.34) 2.3400789406151987 15.880349040031433 1.5140434503555298 5.5128583908081055 1.586246228814149 1.8086747527122498 134.2728210368789 837.9492056297877 84.09567480597272 469.8111585273606 274.828361358512 3136.919338641488 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0030030 5 cell projection organization 158 167 7 6 6 3 3 3 66 164 2314 0.32613 0.84225 0.62312 1.8 308843;58835;338475 tsku;phgdh;nrep TSKU_10094;PHGDH_9470;NREP_9364 135.42823333333334 122.826 92.2997 50.62017890983133 134.83448515243686 48.79739244501266 77.55006666666667 67.6778 49.0864 34.47670049313497 77.03863405248637 33.284596999396435 293.47433333333333 246.456 185.899 137.26321026529038 290.79504053193745 132.8517512179016 92.2997;122.826;191.159 49.0864;67.6778;115.886 185.899;246.456;448.068 2 1 2 308843;58835 TSKU_10094;PHGDH_9470 107.56285 107.56285 21.585353734534916 58.3821 58.3821 13.146105011751565 216.1775 216.1775 42.820265348313576 92.2997;122.826 49.0864;67.6778 185.899;246.456 1 338475 NREP_9364 191.159 191.159 115.886 115.886 448.068 448.068 191.159 115.886 448.068 0 Exp 4,2(0.67);Poly 2,1(0.34) 2.3946975993358004 7.422907471656799 1.7978414297103882 3.334043025970459 0.784329242371292 2.291023015975952 78.14610845009778 192.7103582165689 38.536007338122765 116.56412599521056 138.14638859619797 448.8022780704687 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0070328 8 triglyceride homeostasis 18 18 6 6 5 4 3 3 66 15 2463 0.99887 0.011601 0.011601 16.67 24539;24207;114628 lpl;apoc3;abcg5 LPL_32544;APOC3_32553;ABCG5_7947 489.4518366666667 565.363 2.87451 453.41300006264714 380.1686087355488 418.1696856072377 291.8181233333333 386.851 1.13737 256.71447139784635 239.80910823727658 253.09140241416466 1494.8528033333332 1047.94 8.23841 1753.3226783023645 979.5629759681754 1413.7101548435253 0.0 2.87451 0.5 284.118755 900.118;2.87451;565.363 487.466;1.13737;386.851 3428.38;8.23841;1047.94 0 3 0 3 24539;24207;114628 LPL_32544;APOC3_32553;ABCG5_7947 489.4518366666667 565.363 453.41300006264714 291.8181233333333 386.851 256.71447139784635 1494.8528033333332 1047.94 1753.3226783023645 900.118;2.87451;565.363 487.466;1.13737;386.851 3428.38;8.23841;1047.94 0 Exp 2,1(0.34);Exp 4,1(0.34);Linear,1(0.34) 1.6666441495626663 5.010776519775391 1.5235437154769897 1.783576488494873 0.13319461065346683 1.7036563158035278 -23.633273908213766 1002.5369472415471 1.3183517671520235 582.3178948995146 -489.21858444319196 3478.924191109859 DOWN 0.0 1.0 0.0 GO:0009611 4 response to wounding 115 120 7 7 7 5 5 5 64 115 2363 0.89657 0.22314 0.25732 4.17 338475;59107;24404;25317;24296 nrep;ltbp1;gpx1;fgf1;cyp1a1 NREP_9364;LTBP1_33264;GPX1_33050;FGF1_8633;CYP1A1_8415 345.151724 191.159 8.00432 351.53745331873654 280.2273941018512 323.5041234388123 211.452342 115.886 2.69961 210.49315377889212 179.68104197362175 202.74250650791097 853.89588 448.068 25.2254 949.4389743712187 626.1652337356751 783.1584142942897 191.159;769.394;8.00432;674.162;83.0393 115.886;438.027;2.69961;437.622;63.0271 448.068;2211.2;25.2254;1465.0;119.986 2 3 2 25317;24296 FGF1_8633;CYP1A1_8415 378.60065000000003 378.60065000000003 417.9868696833012 250.32455000000002 250.32455000000002 264.87859398789664 792.493 792.493 951.0685201908431 674.162;83.0393 437.622;63.0271 1465.0;119.986 3 338475;59107;24404 NREP_9364;LTBP1_33264;GPX1_33050 322.85244 191.159 397.4115408577119 185.53753666666668 115.886 225.86718783629027 894.8311333333332 448.068 1159.4478043192169 191.159;769.394;8.00432 115.886;438.027;2.69961 448.068;2211.2;25.2254 0 Exp 2,1(0.2);Hill,1(0.2);Linear,1(0.2);Poly 2,2(0.4) 2.276723392751308 13.45256221294403 1.5140434503555298 6.292444229125977 2.0367138672418132 1.7846373319625854 37.01556023492128 653.2878877650788 26.946957746015556 395.95772625398445 21.675925824763453 1686.1158341752366 DOWN 0.4 0.6 0.0 GO:0008285 6 negative regulation of cell population proliferation 190 199 8 8 7 5 4 4 65 195 2283 0.36263 0.80096 0.65401 2.01 29200;24426;24890;25426 inhba;gstp1;esr1;cyp1b1 INHBA_33300;GSTP1_8762;ESR1_33192;CYP1B1_32710 114.04442499999999 107.1622 12.5403 89.73296930880998 132.93909415842035 108.32033375152811 79.51902749999999 64.50315 3.74981 77.91771211738505 98.96083837840303 94.03389590952553 188.51745 201.75150000000002 51.2968 103.09424167758675 200.03325427516077 121.16670740046945 91.8104;122.514;12.5403;229.313 44.1594;84.8469;3.74981;185.32 186.93;216.573;51.2968;299.27 2 2 2 24426;25426 GSTP1_8762;CYP1B1_32710 175.9135 175.9135 75.51829712394202 135.08345 135.08345 71.04521033683413 257.9215 257.9215 58.47560948378415 122.514;229.313 84.8469;185.32 216.573;299.27 2 29200;24890 INHBA_33300;ESR1_33192 52.17535 52.17535 56.052425255335734 23.954605 23.954605 28.573895113968096 119.1134 119.1134 95.90715547403126 91.8104;12.5403 44.1594;3.74981 186.93;51.2968 0 Hill,2(0.5);Linear,1(0.25);Poly 2,1(0.25) 2.889390787491958 12.721609592437744 1.7318620681762695 5.5128583908081055 1.666035487312125 2.7384445667266846 26.106115077366226 201.98273492263377 3.1596696249626604 155.87838537503734 87.48509315596498 289.549806844035 CONFLICT 0.5 0.5 0.0 GO:0045935 7 positive regulation of nucleobase-containing compound metabolic process 358 387 17 17 16 10 9 9 60 378 2100 0.38202 0.74322 0.73474 2.33 360243;259241;316351;64194;29200;25317;24890;24309;25426 top2a;nr1d2;npas2;insig1;inhba;fgf1;esr1;dbp;cyp1b1 TOP2A_10059;NR1D2_9358;NPAS2_9350;INSIG1_8906;INHBA_33300;FGF1_8633;ESR1_33192;DBP_8439;CYP1B1_32710 130.44229000000053 53.0014 4.48597E-12 215.40836173156964 151.4052628663931 230.63511472156 80.07955666666716 14.3825 4.48597E-12 146.15646496391568 97.17417881573469 156.50441085119564 294.2846000000005 186.93 4.48599E-12 451.5967368365494 327.17147291453534 483.8332128516144 4.48597E-12;9.46041;53.0014;37.6554;91.8104;674.162;12.5403;66.0377;229.313 4.48597E-12;2.2133;14.3825;13.2791;44.1594;437.622;3.74981;19.9899;185.32 4.48599E-12;49.4216;215.15;101.065;186.93;1465.0;51.2968;280.428;299.27 6 3 6 360243;259241;64194;25317;24309;25426 TOP2A_10059;NR1D2_9358;INSIG1_8906;FGF1_8633;DBP_8439;CYP1B1_32710 169.43808500000077 51.84655 261.0332057995738 109.73738333333408 16.6345 175.60386486329242 365.86410000000075 190.7465 552.0769487748419 4.48597E-12;9.46041;37.6554;674.162;66.0377;229.313 4.48597E-12;2.2133;13.2791;437.622;19.9899;185.32 4.48599E-12;49.4216;101.065;1465.0;280.428;299.27 3 316351;29200;24890 NPAS2_9350;INHBA_33300;ESR1_33192 52.450700000000005 53.0014 39.637919236130436 20.76390333333333 14.3825 20.94696809490656 151.1256 186.93 87.59813971814702 53.0014;91.8104;12.5403 14.3825;44.1594;3.74981 215.15;186.93;51.2968 0 Exp 4,1(0.12);Exp 5,1(0.12);Hill,5(0.56);Linear,2(0.23) 2.0862850618413527 19.219574809074402 1.5704141855239868 3.1843981742858887 0.5115861365739042 1.9665359258651733 -10.291172997958313 271.1757529979593 -15.409333776424418 175.56844710975872 -0.7586013998783869 589.3278013998795 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0051336 5 regulation of hydrolase activity 294 317 13 13 11 9 7 7 62 310 2168 0.35803 0.77449 0.71155 2.21 299270;94195;312538;288001;24404;24890;24207 serpina6;s100a9;mcm2;kng1;gpx1;esr1;apoc3 SERPINA6_32325;S100A9_9775;MCM2_9206;KNG1L1_32433;GPX1_33050;ESR1_33192;APOC3_32553 288001(0.1788) 145.7365457142857 8.00432 2.87451 360.60844931056187 52.48484538037113 214.43168256413978 117.15926042857143 2.69961 0.956203 302.0599521682862 39.157228788850425 179.50570926031955 197.63910142857142 25.2254 8.23841 425.01544921840315 86.90734227077532 254.47379826949305 25.7745;963.318;3.76863;3.87556;8.00432;12.5403;2.87451 8.17372;802.143;0.956203;1.25511;2.69961;3.74981;1.13737 103.274;1158.68;22.9217;13.8374;25.2254;51.2968;8.23841 3 4 3 94195;312538;288001 S100A9_9775;MCM2_9206;KNG1L1_32433 323.65406333333334 3.87556 553.9652216181348 268.11810433333335 1.25511 462.479150049161 398.47970000000004 22.9217 658.3684403255446 963.318;3.76863;3.87556 802.143;0.956203;1.25511 1158.68;22.9217;13.8374 4 299270;24404;24890;24207 SERPINA6_32325;GPX1_33050;ESR1_33192;APOC3_32553 12.2984075 10.272310000000001 9.813470548150892 3.9401275 3.22471 3.0195948667812478 47.0086525 38.2611 41.4801933910032 25.7745;8.00432;12.5403;2.87451 8.17372;2.69961;3.74981;1.13737 103.274;25.2254;51.2968;8.23841 0 Exp 4,2(0.29);Hill,4(0.58);Poly 2,1(0.15) 1.6880343381935439 11.86901044845581 1.5235437154769897 2.0197160243988037 0.17629420986242494 1.7056305408477783 -121.40593199814299 412.87902342671435 -106.60988362284675 340.9284044799896 -117.21674952927145 512.4949523864143 CONFLICT 0.42857142857142855 0.5714285714285714 0.0 GO:0032375 8 negative regulation of cholesterol transport 6 7 2 2 2 2 2 2 67 5 2473 0.99938 0.013912 0.013912 28.57 24207;114628 apoc3;abcg5 APOC3_32553;ABCG5_7947 284.118755 284.118755 2.87451 397.7394256183816 284.431311748333 397.73918000091254 193.994185 193.994185 1.13737 272.74072336907903 194.20851364871692 272.7405549425115 528.089205 528.089205 8.23841 735.1800446994357 528.6669337073146 735.1795907010379 0.0 2.87451 0.0 2.87451 2.87451;565.363 1.13737;386.851 8.23841;1047.94 0 2 0 2 24207;114628 APOC3_32553;ABCG5_7947 284.118755 284.118755 397.7394256183816 193.994185 193.994185 272.74072336907903 528.089205 528.089205 735.1800446994357 2.87451;565.363 1.13737;386.851 8.23841;1047.94 0 Exp 4,1(0.5);Linear,1(0.5) 1.6484407026395829 3.307120203971863 1.5235437154769897 1.783576488494873 0.1838709371316876 1.6535601019859314 -267.11996519999997 835.3574752 -184.0051724 571.9935424 -490.8183531999998 1546.9967632 DOWN 0.0 1.0 0.0 GO:0015671 6 oxygen transport 4 7 3 3 3 2 2 2 67 5 2473 0.99938 0.013912 0.013912 28.57 287167;360504 hba-a1;hba-a2 LOC287167_9118;HBA2_32600 140.166 140.166 131.05 12.891970834593442 141.47953049109555 12.757436548849721 92.7986 92.7986 88.5948 5.945070973504146 93.4043283324339 5.8830311281319725 294.1575 294.1575 254.163 56.56076432033041 299.9203340528872 55.97052391980784 0.0 131.05 0.0 131.05 149.282;131.05 97.0024;88.5948 334.152;254.163 0 2 0 2 287167;360504 LOC287167_9118;HBA2_32600 140.166 140.166 12.891970834593442 92.7986 92.7986 5.945070973504146 294.1575 294.1575 56.56076432033041 149.282;131.05 97.0024;88.5948 334.152;254.163 0 Poly 2,2(1) 1.8428698927683922 3.69141685962677 1.743384599685669 1.948032259941101 0.14470774832057676 1.845708429813385 122.29863999999999 158.03336 84.55915200000001 101.03804799999997 215.76828000000006 372.54672 DOWN 0.0 1.0 0.0 GO:0019538 4 protein metabolic process 588 639 24 23 18 17 12 12 57 627 1851 0.084243 0.95376 0.15915 1.88 83472;171497;94195;29200;24404;84586;171142;298452;81508;24207;25748;360887 ugdh;sgk2;s100a9;inhba;gpx1;fgl2;ehhadh;dph2;bhmt;apoc3;alas2;coq8a UGDH_10131;SGK2_32380;S100A9_9775;INHBA_33300;GPX1_33050;FGL2_32918;EHHADH_8534;DPH2_8490;BHMT_8143;APOC3_32553;ALAS2_8019;ADCK3_7987 248.77500250000003 135.95600000000002 2.87451 316.4457044014835 183.51916939985472 268.51381549109726 172.04611583333335 90.70315 1.13737 244.2743615594839 120.14612331022198 191.56278764608433 470.38830916666666 280.92650000000003 8.23841 552.8898911251342 387.11743036119356 547.8051150713617 59.3662;156.37;963.318;91.8104;8.00432;146.406;166.899;734.134;5.5396;2.87451;125.506;525.072 25.4417;100.616;802.143;44.1594;2.69961;95.6156;105.26;463.289;1.97501;1.13737;85.7907;336.426 135.068;343.205;1158.68;186.93;25.2254;325.091;384.658;1764.85;37.8319;8.23841;236.762;1038.12 3 9 3 83472;171497;94195 UGDH_10131;SGK2_32380;S100A9_9775 393.0180666666667 156.37 496.2700321131765 309.40023333333335 100.616 428.3799358301732 545.651 343.205 541.0024665590722 59.3662;156.37;963.318 25.4417;100.616;802.143 135.068;343.205;1158.68 9 29200;24404;84586;171142;298452;81508;24207;25748;360887 INHBA_33300;GPX1_33050;FGL2_32918;EHHADH_8534;DPH2_8490;BHMT_8143;APOC3_32553;ALAS2_8019;ADCK3_7987 200.6939811111111 125.506 256.35048917148555 126.26141 85.7907 163.51079767391747 445.3007455555555 236.762 586.7851310978423 91.8104;8.00432;146.406;166.899;734.134;5.5396;2.87451;125.506;525.072 44.1594;2.69961;95.6156;105.26;463.289;1.97501;1.13737;85.7907;336.426 186.93;25.2254;325.091;384.658;1764.85;37.8319;8.23841;236.762;1038.12 0 Exp 2,1(0.09);Exp 4,2(0.17);Hill,3(0.25);Linear,1(0.09);Poly 2,5(0.42) 1.7096839897554776 20.645742058753967 1.5039241313934326 2.2924909591674805 0.21266720315521007 1.6785037517547607 69.72899013230466 427.8210148676954 33.83488479889118 310.2573468677755 157.56140424281392 783.2152140905193 DOWN 0.25 0.75 0.0 GO:0045454 4 cell redox homeostasis 21 21 4 4 3 3 3 3 66 18 2460 0.99791 0.017844 0.017844 14.29 116686;24404;25283 gsr;gpx1;gclc GSR_8755;GPX1_33050;GCLC_8699 74.50474 69.5519 8.00432 69.11007469562452 70.29522258221118 66.9612019699934 46.83566999999999 41.1016 2.69961 47.26468669792174 43.849506973935156 45.69890896946127 143.20746666666665 124.212 25.2254 128.5368438365177 134.93676164826908 124.15075955188487 0.5 38.77811 1.5 107.75495000000001 69.5519;8.00432;145.958 41.1016;2.69961;96.7058 124.212;25.2254;280.185 2 1 2 116686;25283 GSR_8755;GCLC_8699 107.75495000000001 107.75495000000001 54.02727143401748 68.9037 68.9037 39.31810688245302 202.1985 202.1985 110.28956598200936 69.5519;145.958 41.1016;96.7058 124.212;280.185 1 24404 GPX1_33050 8.00432 8.00432 2.69961 2.69961 25.2254 25.2254 8.00432 2.69961 25.2254 0 Exp 4,1(0.34);Hill,1(0.34);Poly 2,1(0.34) 1.785733008592346 5.357581257820129 1.7603585720062256 1.8125853538513184 0.02613486449938265 1.7846373319625854 -3.7006716492985703 152.71015164929855 -6.649357992888554 100.32069799288854 -2.2456648573381415 288.6605981906715 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0019395 7 fatty acid oxidation 39 43 3 3 3 2 2 2 67 41 2437 0.89103 0.32589 0.32589 4.65 84029;171142 hao2;ehhadh HAO2_8778;EHHADH_8534 153.8775 153.8775 140.856 18.415181902441223 158.36856551833878 17.28524184152384 99.39095 99.39095 93.5219 8.300090108245866 101.41516288487549 7.790803565641456 333.79150000000004 333.79150000000004 282.925 71.9360941704508 351.33516119023 67.52215598294207 140.856;166.899 93.5219;105.26 282.925;384.658 0 2 0 2 84029;171142 HAO2_8778;EHHADH_8534 153.8775 153.8775 18.415181902441223 99.39095 99.39095 8.300090108245866 333.79150000000004 333.79150000000004 71.9360941704508 140.856;166.899 93.5219;105.26 282.925;384.658 0 Poly 2,2(1) 1.785942254197013 3.6247689723968506 1.5039241313934326 2.120844841003418 0.4362288172196375 1.8123844861984253 128.35536 179.39964 87.887612 110.894288 234.09316000000004 433.4898400000001 DOWN 0.0 1.0 0.0 GO:0002793 7 positive regulation of peptide secretion 97 104 5 5 4 5 4 4 65 100 2378 0.85154 0.31034 0.36446 3.85 94195;361042;24614;24539 s100a9;pck2;orm1;lpl S100A9_9775;PCK2_9440;ORM1_9400;LPL_32544 633.1509075 781.3040000000001 6.67763 437.2685243715134 372.49369358887805 488.5450324442503 430.8839875 459.95550000000003 1.48195 329.3545835267323 237.90881077864864 328.70693371902456 1509.580625 1286.0 37.9425 1411.843613743473 1033.269795754906 1538.210636593104 963.318;6.67763;662.49;900.118 802.143;1.48195;432.445;487.466 1158.68;37.9425;1413.32;3428.38 3 1 3 94195;361042;24614 S100A9_9775;PCK2_9440;ORM1_9400 544.1618766666667 662.49 489.17415912650733 412.0233166666667 432.445 400.72099160064084 869.9808333333334 1158.68 731.7282442970773 963.318;6.67763;662.49 802.143;1.48195;432.445 1158.68;37.9425;1413.32 1 24539 LPL_32544 900.118 900.118 487.466 487.466 3428.38 3428.38 900.118 487.466 3428.38 0 Exp 2,1(0.25);Hill,1(0.25);Linear,1(0.25);Poly 2,1(0.25) 1.6196269026169816 6.487051963806152 1.528982162475586 1.7056305408477783 0.09604625945779068 1.626219630241394 204.62775361591673 1061.6740613840834 108.11649564380235 753.6514793561976 125.97388353139627 2893.1873664686036 UP 0.75 0.25 0.0 GO:1903047 4 mitotic cell cycle process 136 146 17 17 17 5 5 5 64 141 2337 0.79936 0.36181 0.59398 3.42 360243;29685;312538;293502;29200 top2a;mcm6;mcm2;kif22;inhba TOP2A_10059;MCM6_9210;MCM2_9206;KIF22_8963;INHBA_33300 19.683059200000898 1.87441 4.48597E-12 40.34438189728539 14.18670868246971 35.068270246401276 9.178886200000896 0.496857 4.48597E-12 19.557821630345646 6.540579526570693 16.987314709643428 44.7708740000009 9.53 4.48599E-12 79.93262649600462 33.31663237301854 69.7734661464391 4.48597E-12;1.87441;3.76863;0.961856;91.8104 4.48597E-12;0.496857;0.956203;0.281971;44.1594 4.48599E-12;9.53;22.9217;4.47267;186.93 4 1 4 360243;29685;312538;293502 TOP2A_10059;MCM6_9210;MCM2_9206;KIF22_8963 1.6512240000011214 1.418133 1.6057178142518471 0.4337577500011215 0.38941400000000004 0.4033673089360194 9.231092500001122 7.001334999999999 9.922663164772386 4.48597E-12;1.87441;3.76863;0.961856 4.48597E-12;0.496857;0.956203;0.281971 4.48599E-12;9.53;22.9217;4.47267 1 29200 INHBA_33300 91.8104 91.8104 44.1594 44.1594 186.93 186.93 91.8104 44.1594 186.93 0 Exp 4,1(0.2);Hill,4(0.8) 1.8785666534669425 9.486688375473022 1.5280487537384033 2.2924909591674805 0.29877450448437676 1.8211764097213745 -15.680350729555599 55.046469129557394 -7.964300313648405 26.322072713650197 -25.293162294344626 114.83491029434643 UP 0.8 0.2 0.0 GO:0030099 5 myeloid cell differentiation 58 64 2 2 2 2 2 2 67 62 2416 0.75029 0.52306 0.69168 3.12 363465;25748 pir;alas2 PIR_9487;ALAS2_8019 138.8595 138.8595 125.506 18.884700805149063 139.08726872909702 18.88195348241502 71.12365 71.12365 56.4566 20.742341030004283 70.87347623745819 20.73932346008595 304.27 304.27 236.762 95.470729168683 305.42147424749163 95.45684020600474 152.213;125.506 56.4566;85.7907 371.778;236.762 1 1 1 363465 PIR_9487 152.213 152.213 56.4566 56.4566 371.778 371.778 152.213 56.4566 371.778 1 25748 ALAS2_8019 125.506 125.506 85.7907 85.7907 236.762 236.762 125.506 85.7907 236.762 0 Hill,1(0.5);Poly 2,1(0.5) 1.9679497285001752 3.960813283920288 1.7586312294006348 2.2021820545196533 0.31363779624254645 1.980406641960144 112.68664000000001 165.03235999999998 42.376232 99.871068 171.95431999999997 436.58568 CONFLICT 0.5 0.5 0.0 GO:0031329 6 regulation of cellular catabolic process 171 183 10 10 8 6 4 4 65 179 2299 0.43939 0.74315 0.81532 2.19 24404;25283;310395;24207 gpx1;gclc;noct;apoc3 GPX1_33050;GCLC_8699;CCRN4L_8232;APOC3_32553 205.52820749999998 76.98116 2.87451 313.58191358014165 185.4406054945095 312.54512397997433 133.55719499999998 49.702704999999995 1.13737 205.015481130277 120.35145615189687 204.32826817280034 434.78220250000004 152.7052 8.23841 672.0760875542004 393.9109255011201 668.9579061322355 8.00432;145.958;665.276;2.87451 2.69961;96.7058;433.686;1.13737 25.2254;280.185;1425.48;8.23841 2 2 2 25283;310395 GCLC_8699;CCRN4L_8232 405.61699999999996 405.61699999999996 367.2132793922355 265.1959 265.1959 238.28098454559898 852.8325 852.8325 809.845860959047 145.958;665.276 96.7058;433.686 280.185;1425.48 2 24404;24207 GPX1_33050;APOC3_32553 5.439415 5.439415 3.627323437198562 1.9184899999999998 1.9184899999999998 1.1046704978408723 16.731905 16.731905 12.011615820948068 8.00432;2.87451 2.69961;1.13737 25.2254;8.23841 0 Exp 4,1(0.25);Hill,1(0.25);Linear,1(0.25);Poly 2,1(0.25) 1.7030446611111294 6.826050877571106 1.5235437154769897 1.7846373319625854 0.1225851245456811 1.7589349150657654 -101.78206780853881 512.8384828085387 -67.35797650767145 334.4723665076715 -223.8523633031166 1093.4167683031167 CONFLICT 0.5 0.5 0.0 GO:0031328 7 positive regulation of cellular biosynthetic process 404 436 18 18 17 11 10 10 59 426 2052 0.34596 0.76844 0.63018 2.29 360243;259241;316351;64194;29200;25317;24890;24309;25426;24207 top2a;nr1d2;npas2;insig1;inhba;fgf1;esr1;dbp;cyp1b1;apoc3 TOP2A_10059;NR1D2_9358;NPAS2_9350;INSIG1_8906;INHBA_33300;FGF1_8633;ESR1_33192;DBP_8439;CYP1B1_32710;APOC3_32553 117.68551200000044 45.3284 4.48597E-12 207.05669730125874 130.2760355982565 219.21078912764085 72.18533800000046 13.8308 4.48597E-12 140.0406210743987 83.51247226396394 148.32513234639597 265.67998100000045 143.9975 4.48599E-12 435.27221141915857 281.80168221734664 460.54870575178177 4.48597E-12;9.46041;53.0014;37.6554;91.8104;674.162;12.5403;66.0377;229.313;2.87451 4.48597E-12;2.2133;14.3825;13.2791;44.1594;437.622;3.74981;19.9899;185.32;1.13737 4.48599E-12;49.4216;215.15;101.065;186.93;1465.0;51.2968;280.428;299.27;8.23841 6 4 6 360243;259241;64194;25317;24309;25426 TOP2A_10059;NR1D2_9358;INSIG1_8906;FGF1_8633;DBP_8439;CYP1B1_32710 169.43808500000077 51.84655 261.0332057995738 109.73738333333408 16.6345 175.60386486329242 365.86410000000075 190.7465 552.0769487748419 4.48597E-12;9.46041;37.6554;674.162;66.0377;229.313 4.48597E-12;2.2133;13.2791;437.622;19.9899;185.32 4.48599E-12;49.4216;101.065;1465.0;280.428;299.27 4 316351;29200;24890;24207 NPAS2_9350;INHBA_33300;ESR1_33192;APOC3_32553 40.0566525 32.770849999999996 40.766318793529685 15.85727 9.066155 19.718447815445987 115.40380250000001 119.1134 101.09307586531675 53.0014;91.8104;12.5403;2.87451 14.3825;44.1594;3.74981;1.13737 215.15;186.93;51.2968;8.23841 0 Exp 4,2(0.2);Exp 5,1(0.1);Hill,5(0.5);Linear,2(0.2) 2.021723576158061 20.74311852455139 1.5235437154769897 3.1843981742858887 0.5197022226307655 1.934571921825409 -10.649558579746838 246.02058257974772 -14.612738197776068 158.98341419777694 -4.10453069152652 535.4644926915274 UP 0.6 0.4 0.0 GO:0031103 7 axon regeneration 17 18 2 2 2 1 1 1 68 17 2461 0.91625 0.39106 0.39106 5.56 338475 nrep NREP_9364 191.159 191.159 191.159 191.159 115.886 115.886 115.886 115.88599999999998 448.068 448.068 448.068 448.068 0.0 191.159 191.159 115.886 448.068 0 1 0 1 338475 NREP_9364 191.159 191.159 115.886 115.886 448.068 448.068 191.159 115.886 448.068 0 Poly 2,1(1) 2.291023015975952 2.291023015975952 2.291023015975952 2.291023015975952 0.0 2.291023015975952 191.159 191.159 115.886 115.886 448.068 448.068 DOWN 0.0 1.0 0.0 GO:0046395 6 carboxylic acid catabolic process 80 87 6 6 6 4 4 4 65 83 2395 0.91573 0.20799 0.29592 4.6 361042;116682;171142;296925 pck2;kynu;ehhadh;aass PCK2_9440;KYNU_8979;EHHADH_8534;AASS_7936 69.9420975 53.529315 5.81076 78.40575877105897 63.16879749005126 81.58587879880294 45.517485 37.663995 1.48195 51.929223430947175 40.063162167075234 53.50647538979722 149.533925 99.69924999999999 14.0792 169.53475078900243 142.6890981630639 177.93632072222914 6.67763;100.381;166.899;5.81076 1.48195;72.7231;105.26;2.60489 37.9425;161.456;384.658;14.0792 1 3 1 361042 PCK2_9440 6.67763 6.67763 1.48195 1.48195 37.9425 37.9425 6.67763 1.48195 37.9425 3 116682;171142;296925 KYNU_8979;EHHADH_8534;AASS_7936 91.03025333333333 100.381 80.95018600344618 60.195996666666666 72.7231 52.46154916432638 186.73106666666664 161.456 186.5778215614422 100.381;166.899;5.81076 72.7231;105.26;2.60489 161.456;384.658;14.0792 0 Hill,2(0.5);Poly 2,2(0.5) 1.8024823117990472 7.335469722747803 1.5039241313934326 2.3450815677642822 0.3993486483757672 1.743232011795044 -6.895546095637798 146.7797410956378 -5.373153962328232 96.40812396232825 -16.61013077322238 315.67798077322243 DOWN 0.25 0.75 0.0 GO:0050801 6 ion homeostasis 172 181 11 11 9 9 7 7 62 174 2304 0.88732 0.21551 0.33575 3.87 24567;288001;29739;25283;24890;117517;25748 mt1;kng1;gclm;gclc;esr1;c7;alas2 MT1A_9255;KNG1L1_32433;GCLM_8700;GCLC_8699;ESR1_33192;C7_8179;ALAS2_8019 288001(0.1788) 200.04355142857142 125.506 3.87556 280.9956789766571 123.05769334332749 166.50977389021782 118.5244457142857 69.2223 1.25511 189.77520945071547 62.3528861432237 110.60648606268886 337.25845714285714 280.185 13.8374 329.41212158615156 264.3178551907055 229.24606138574757 818.334;3.87556;190.233;145.958;12.5403;103.858;125.506 540.216;1.25511;69.2223;96.7058;3.74981;32.7314;85.7907 988.495;13.8374;496.452;280.185;51.2968;293.781;236.762 3 4 3 288001;29739;25283 KNG1L1_32433;GCLM_8700;GCLC_8699 113.35552 145.958 97.3625448386144 55.727736666666665 69.2223 49.135384246355834 263.49146666666667 280.185 241.7399813325328 3.87556;190.233;145.958 1.25511;69.2223;96.7058 13.8374;496.452;280.185 4 24567;24890;117517;25748 MT1A_9255;ESR1_33192;C7_8179;ALAS2_8019 265.059575 114.682 372.08409519147125 165.6219775 59.26105 252.02924351448058 392.5837 265.2715 410.54005135409955 818.334;12.5403;103.858;125.506 540.216;3.74981;32.7314;85.7907 988.495;51.2968;293.781;236.762 0 Exp 4,1(0.15);Hill,3(0.43);Poly 2,3(0.43) 1.844964752803198 13.003199219703674 1.5755720138549805 2.3371741771698 0.2424087825890263 1.7603585720062256 -8.120960667101684 408.2080635242445 -22.062996865014867 259.1118882935863 93.22654242406102 581.2903718616533 CONFLICT 0.42857142857142855 0.5714285714285714 0.0 GO:0021773 8 striatal medium spiny neuron differentiation 1 1 1 1 1 1 1 1 68 0 2478 1.0 0.027091 0.027091 100.0 29200 inhba INHBA_33300 91.8104 91.8104 91.8104 91.8104 44.1594 44.1594 44.1594 44.1594 186.93 186.93 186.93 186.93 0.0 91.8104 0.0 91.8104 91.8104 44.1594 186.93 0 1 0 1 29200 INHBA_33300 91.8104 91.8104 44.1594 44.1594 186.93 186.93 91.8104 44.1594 186.93 0 Hill,1(1) 2.2924909591674805 2.2924909591674805 2.2924909591674805 2.2924909591674805 0.0 2.2924909591674805 91.8104 91.8104 44.1594 44.1594 186.93 186.93 DOWN 0.0 1.0 0.0 GO:0042701 8 progesterone secretion 1 1 1 1 1 1 1 1 68 0 2478 1.0 0.027091 0.027091 100.0 29200 inhba INHBA_33300 91.8104 91.8104 91.8104 91.8104 44.1594 44.1594 44.1594 44.1594 186.93 186.93 186.93 186.93 0.0 91.8104 0.0 91.8104 91.8104 44.1594 186.93 0 1 0 1 29200 INHBA_33300 91.8104 91.8104 44.1594 44.1594 186.93 186.93 91.8104 44.1594 186.93 0 Hill,1(1) 2.2924909591674805 2.2924909591674805 2.2924909591674805 2.2924909591674805 0.0 2.2924909591674805 91.8104 91.8104 44.1594 44.1594 186.93 186.93 DOWN 0.0 1.0 0.0 GO:1901698 4 response to nitrogen compound 416 438 30 30 22 20 13 13 56 425 2053 0.70966 0.40628 0.74586 2.97 361042;24614;116682;64194;25663;24426;24404;29739;25283;25426;81508;25612;24207 pck2;orm1;kynu;insig1;il1r1;gstp1;gpx1;gclm;gclc;cyp1b1;bhmt;asns;apoc3 PCK2_9440;ORM1_9400;KYNU_8979;INSIG1_8906;IL1R1_8893;GSTP1_8762;GPX1_33050;GCLM_8700;GCLC_8699;CYP1B1_32710;BHMT_8143;ASNS_8091;APOC3_32553 122.63987230769229 76.6218 2.87451 179.35112842083774 93.4119216019642 136.44512859912524 76.31549538461537 27.5215 1.13737 120.14811209719143 59.42311669663745 94.99685641464978 252.07979307692307 161.456 8.23841 377.1796469652759 182.8908414381903 271.6039631924234 6.67763;662.49;100.381;37.6554;76.6218;122.514;8.00432;190.233;145.958;229.313;5.5396;6.05608;2.87451 1.48195;432.445;72.7231;13.2791;27.5215;84.8469;2.69961;69.2223;96.7058;185.32;1.97501;2.7438;1.13737 37.9425;1413.32;161.456;101.065;185.143;216.573;25.2254;496.452;280.185;299.27;37.8319;14.3351;8.23841 9 4 9 361042;24614;64194;25663;24426;29739;25283;25426;25612 PCK2_9440;ORM1_9400;INSIG1_8906;IL1R1_8893;GSTP1_8762;GCLM_8700;GCLC_8699;CYP1B1_32710;ASNS_8091 164.16876777777776 122.514 202.7273728824989 101.50737222222223 69.2223 137.3429502967369 338.2539555555556 216.573 429.4332877743413 6.67763;662.49;37.6554;76.6218;122.514;190.233;145.958;229.313;6.05608 1.48195;432.445;13.2791;27.5215;84.8469;69.2223;96.7058;185.32;2.7438 37.9425;1413.32;101.065;185.143;216.573;496.452;280.185;299.27;14.3351 4 116682;24404;81508;24207 KYNU_8979;GPX1_33050;BHMT_8143;APOC3_32553 29.1998575 6.77196 47.50030723929153 19.6337725 2.33731 35.39864099299141 58.1879275 31.52865 69.90504314453304 100.381;8.00432;5.5396;2.87451 72.7231;2.69961;1.97501;1.13737 161.456;25.2254;37.8319;8.23841 0 Exp 4,2(0.16);Exp 5,1(0.08);Hill,5(0.39);Linear,2(0.16);Poly 2,3(0.24) 2.091184855347271 29.57447636127472 1.5235437154769897 5.5128583908081055 1.1574914822226465 1.7846373319625854 25.14348830200241 220.13625631338215 11.002237655340537 141.62875311389024 47.04260137679796 457.1169847770482 UP 0.6923076923076923 0.3076923076923077 0.0 GO:0042493 4 response to drug 436 472 47 47 40 30 24 24 45 448 2030 0.99967 8.5824E-4 0.0013376 5.08 360243;94195;361042;24614;316351;24539;170496;116682;29200;25663;360504;24426;300850;116686;24404;29739;25283;25426;24296;54232;25612;24207;25748;114628 top2a;s100a9;pck2;orm1;npas2;lpl;lcn2;kynu;inhba;il1r1;hba-a2;gstp1;gsta4;gsr;gpx1;gclm;gclc;cyp1b1;cyp1a1;car3;asns;apoc3;alas2;abcg5 TOP2A_10059;S100A9_9775;PCK2_9440;ORM1_9400;NPAS2_9350;LPL_32544;LCN2_32481;KYNU_8979;INHBA_33300;IL1R1_8893;HBA2_32600;GSTP1_8762;GSTA4_8757;GSR_8755;GPX1_33050;GCLM_8700;GCLC_8699;CYP1B1_32710;CYP1A1_8415;CAR3_8196;ASNS_8091;APOC3_32553;ALAS2_8019;ABCG5_7947 243.72727791666685 111.44749999999999 4.48597E-12 318.242949557523 206.02921803360238 275.0383322513682 158.52424416666685 70.9727 4.48597E-12 215.85948474247078 133.97859691164302 178.5207635031934 603.6616058333335 215.8615 4.48599E-12 1045.1317745242864 495.1822751213061 926.8773212779038 22.5 967.972 4.48597E-12;963.318;6.67763;662.49;53.0014;900.118;972.626;100.381;91.8104;76.6218;131.05;122.514;339.498;69.5519;8.00432;190.233;145.958;229.313;83.0393;3.44933;6.05608;2.87451;125.506;565.363 4.48597E-12;802.143;1.48195;432.445;14.3825;487.466;551.931;72.7231;44.1594;27.5215;88.5948;84.8469;260.156;41.1016;2.69961;69.2223;96.7058;185.32;63.0271;2.13143;2.7438;1.13737;85.7907;386.851 4.48599E-12;1158.68;37.9425;1413.32;215.15;3428.38;4084.57;161.456;186.93;185.143;254.163;216.573;486.944;124.212;25.2254;496.452;280.185;299.27;119.986;6.02113;14.3351;8.23841;236.762;1047.94 14 10 14 360243;94195;361042;24614;170496;25663;24426;300850;116686;29739;25283;25426;24296;25612 TOP2A_10059;S100A9_9775;PCK2_9440;ORM1_9400;LCN2_32481;IL1R1_8893;GSTP1_8762;GSTA4_8757;GSR_8755;GCLM_8700;GCLC_8699;CYP1B1_32710;CYP1A1_8415;ASNS_8091 276.2783364285718 134.236 339.9423426255123 187.04613928571462 77.03460000000001 244.1718468480328 636.9723285714289 248.37900000000002 1078.0234686135743 4.48597E-12;963.318;6.67763;662.49;972.626;76.6218;122.514;339.498;69.5519;190.233;145.958;229.313;83.0393;6.05608 4.48597E-12;802.143;1.48195;432.445;551.931;27.5215;84.8469;260.156;41.1016;69.2223;96.7058;185.32;63.0271;2.7438 4.48599E-12;1158.68;37.9425;1413.32;4084.57;185.143;216.573;486.944;124.212;496.452;280.185;299.27;119.986;14.3351 10 316351;24539;116682;29200;360504;24404;54232;24207;25748;114628 NPAS2_9350;LPL_32544;KYNU_8979;INHBA_33300;HBA2_32600;GPX1_33050;CAR3_8196;APOC3_32553;ALAS2_8019;ABCG5_7947 198.155796 96.0957 296.5571468780484 118.59359100000002 58.44125 172.9804627935739 557.026594 201.04000000000002 1052.9259398102433 53.0014;900.118;100.381;91.8104;131.05;8.00432;3.44933;2.87451;125.506;565.363 14.3825;487.466;72.7231;44.1594;88.5948;2.69961;2.13143;1.13737;85.7907;386.851 215.15;3428.38;161.456;186.93;254.163;25.2254;6.02113;8.23841;236.762;1047.94 0 Exp 2,1(0.05);Exp 4,3(0.13);Hill,8(0.34);Linear,5(0.21);Poly 2,7(0.3) 2.2222030414640814 59.9956796169281 1.5235437154769897 6.759152412414551 1.517830806709634 1.798611342906952 116.40358060981141 371.05097522352236 72.16246385267335 244.88602448066047 185.52181077950996 1021.8014008871569 CONFLICT 0.5833333333333334 0.4166666666666667 0.0 GO:0071417 5 cellular response to organonitrogen compound 203 213 16 16 10 13 7 7 62 206 2272 0.78471 0.35438 0.51169 3.29 361042;24614;64194;24426;29739;25283;25426 pck2;orm1;insig1;gstp1;gclm;gclc;cyp1b1 PCK2_9440;ORM1_9400;INSIG1_8906;GSTP1_8762;GCLM_8700;GCLC_8699;CYP1B1_32710 199.2630042857143 145.958 6.67763 218.899432796127 151.25832106683018 166.93727514806432 126.18586428571429 84.8469 1.48195 147.99399745114866 98.59573285561004 117.55777569596344 406.4010714285714 280.185 37.9425 468.05074398709064 289.65407676783155 340.4004306526676 6.67763;662.49;37.6554;122.514;190.233;145.958;229.313 1.48195;432.445;13.2791;84.8469;69.2223;96.7058;185.32 37.9425;1413.32;101.065;216.573;496.452;280.185;299.27 7 0 7 361042;24614;64194;24426;29739;25283;25426 PCK2_9440;ORM1_9400;INSIG1_8906;GSTP1_8762;GCLM_8700;GCLC_8699;CYP1B1_32710 199.2630042857143 145.958 218.899432796127 126.18586428571429 84.8469 147.99399745114866 406.4010714285714 280.185 468.05074398709064 6.67763;662.49;37.6554;122.514;190.233;145.958;229.313 1.48195;432.445;13.2791;84.8469;69.2223;96.7058;185.32 37.9425;1413.32;101.065;216.573;496.452;280.185;299.27 0 0 Exp 5,1(0.15);Hill,2(0.29);Linear,2(0.29);Poly 2,2(0.29) 2.23053175139974 17.4107084274292 1.528982162475586 5.5128583908081055 1.4476099283946104 1.90879225730896 37.10003511845278 361.42597345297577 16.550376705615733 235.82135186581286 59.66422795496294 753.1379149021799 UP 1.0 0.0 0.0 GO:1902969 9 mitotic DNA replication 1 1 1 1 1 1 1 1 68 0 2478 1.0 0.027091 0.027091 100.0 29685 mcm6 MCM6_9210 1.87441 1.87441 1.87441 1.87441 0.496857 0.496857 0.496857 0.49685700000000005 9.53 9.53 9.53 9.53 0.0 1.87441 0.0 1.87441 1.87441 0.496857 9.53 1 0 1 29685 MCM6_9210 1.87441 1.87441 0.496857 0.496857 9.53 9.53 1.87441 0.496857 9.53 0 0 Hill,1(1) 1.8211764097213745 1.8211764097213745 1.8211764097213745 1.8211764097213745 0.0 1.8211764097213745 1.87441 1.87441 0.496857 0.496857 9.53 9.53 UP 1.0 0.0 0.0 GO:1901564 4 organonitrogen compound metabolic process 832 911 50 49 40 37 28 28 41 883 1595 0.83486 0.23472 0.44503 3.07 83472;266730;171497;94195;293656;287877;293820;58835;680308;116682;29200;84029;24426;300850;116686;24404;29739;25283;84586;171142;298452;24296;81508;25612;24207;25748;360887;296925 ugdh;slc17a3;sgk2;s100a9;rgd1307603;pycr1;psat1;phgdh;mthfd2;kynu;inhba;hao2;gstp1;gsta4;gsr;gpx1;gclm;gclc;fgl2;ehhadh;dph2;cyp1a1;bhmt;asns;apoc3;alas2;coq8a;aass UGDH_10131;SLC17A3_9840;SGK2_32380;S100A9_9775;RGD1307603_9684;PYCR1_9631;PSAT1_9583;PHGDH_9470;MTHFD2_9261;KYNU_8979;INHBA_33300;HAO2_8778;GSTP1_8762;GSTA4_8757;GSR_8755;GPX1_33050;GCLM_8700;GCLC_8699;FGL2_32918;EHHADH_8534;DPH2_8490;CYP1A1_8415;BHMT_8143;ASNS_8091;APOC3_32553;ALAS2_8019;ADCK3_7987;AASS_7936 186.4224775 122.66999999999999 2.87451 238.15247948540215 150.44227588189707 194.51080977261674 125.52849214285713 70.9727 1.13737 179.34594674883076 98.65624664485158 137.9794243964043 353.72432535714285 226.66750000000002 8.23841 429.41463633514076 297.0456432030168 395.27803238333564 59.3662;93.3839;156.37;963.318;32.0155;132.668;27.1579;122.826;622.58;100.381;91.8104;140.856;122.514;339.498;69.5519;8.00432;190.233;145.958;146.406;166.899;734.134;83.0393;5.5396;6.05608;2.87451;125.506;525.072;5.81076 25.4417;68.9252;100.616;802.143;12.3892;90.3184;10.0144;67.6778;414.266;72.7231;44.1594;93.5219;84.8469;260.156;41.1016;2.69961;69.2223;96.7058;95.6156;105.26;463.289;63.0271;1.97501;2.7438;1.13737;85.7907;336.426;2.60489 135.068;143.418;343.205;1158.68;78.5761;239.858;103.876;246.456;1250.29;161.456;186.93;282.925;216.573;486.944;124.212;25.2254;496.452;280.185;325.091;384.658;1764.85;119.986;37.8319;14.3351;8.23841;236.762;1038.12;14.0792 15 13 15 83472;266730;171497;94195;287877;293820;58835;680308;24426;300850;116686;29739;25283;24296;25612 UGDH_10131;SLC17A3_9840;SGK2_32380;S100A9_9775;PYCR1_9631;PSAT1_9583;PHGDH_9470;MTHFD2_9261;GSTP1_8762;GSTA4_8757;GSR_8755;GCLM_8700;GCLC_8699;CYP1A1_8415;ASNS_8091 208.96801866666664 122.826 257.7685225507625 146.4804 69.2223 209.80514617024326 357.30253999999996 239.858 369.8908676138946 59.3662;93.3839;156.37;963.318;132.668;27.1579;122.826;622.58;122.514;339.498;69.5519;190.233;145.958;83.0393;6.05608 25.4417;68.9252;100.616;802.143;90.3184;10.0144;67.6778;414.266;84.8469;260.156;41.1016;69.2223;96.7058;63.0271;2.7438 135.068;143.418;343.205;1158.68;239.858;103.876;246.456;1250.29;216.573;486.944;124.212;496.452;280.185;119.986;14.3351 13 293656;116682;29200;84029;24404;84586;171142;298452;81508;24207;25748;360887;296925 RGD1307603_9684;KYNU_8979;INHBA_33300;HAO2_8778;GPX1_33050;FGL2_32918;EHHADH_8534;DPH2_8490;BHMT_8143;APOC3_32553;ALAS2_8019;ADCK3_7987;AASS_7936 160.40839153846153 100.381 220.7377197334198 101.35321384615385 72.7231 140.83585359260044 349.59561615384615 186.93 505.20902412055415 32.0155;100.381;91.8104;140.856;8.00432;146.406;166.899;734.134;5.5396;2.87451;125.506;525.072;5.81076 12.3892;72.7231;44.1594;93.5219;2.69961;95.6156;105.26;463.289;1.97501;1.13737;85.7907;336.426;2.60489 78.5761;161.456;186.93;282.925;25.2254;325.091;384.658;1764.85;37.8319;8.23841;236.762;1038.12;14.0792 0 Exp 2,1(0.04);Exp 4,5(0.18);Hill,7(0.25);Linear,3(0.11);Poly 2,12(0.43) 1.9843842707984691 60.177754402160645 1.5039241313934326 6.292444229125977 1.140427662467699 1.7625030279159546 98.20956462355002 274.63539037645 59.09782381857964 191.9591604671346 194.66691816677954 512.7817325475061 CONFLICT 0.5357142857142857 0.4642857142857143 0.0 GO:0009892 5 negative regulation of metabolic process 589 626 28 28 22 16 11 11 58 615 1863 0.056267 0.97126 0.11763 1.76 299270;24614;259241;288001;64194;24426;24404;25283;24890;310395;24207 serpina6;orm1;nr1d2;kng1;insig1;gstp1;gpx1;gclc;esr1;noct;apoc3 SERPINA6_32325;ORM1_9400;NR1D2_9358;KNG1L1_32433;INSIG1_8906;GSTP1_8762;GPX1_33050;GCLC_8699;ESR1_33192;CCRN4L_8232;APOC3_32553 288001(0.1788) 154.22027272727271 25.7745 2.87451 256.63049719543585 115.5640313828533 233.544449442894 98.19924727272728 8.17372 1.13737 169.06847126923842 72.26547586545813 153.82968196533426 335.26514636363635 101.065 8.23841 542.705576229553 258.62184930976804 493.0978589619783 25.7745;662.49;9.46041;3.87556;37.6554;122.514;8.00432;145.958;12.5403;665.276;2.87451 8.17372;432.445;2.2133;1.25511;13.2791;84.8469;2.69961;96.7058;3.74981;433.686;1.13737 103.274;1413.32;49.4216;13.8374;101.065;216.573;25.2254;280.185;51.2968;1425.48;8.23841 7 4 7 24614;259241;288001;64194;24426;25283;310395 ORM1_9400;NR1D2_9358;KNG1L1_32433;INSIG1_8906;GSTP1_8762;GCLC_8699;CCRN4L_8232 235.31848142857143 122.514 297.6848190046253 152.06160142857144 84.8469 195.77492472475888 499.98314285714287 216.573 634.8018393923121 662.49;9.46041;3.87556;37.6554;122.514;145.958;665.276 432.445;2.2133;1.25511;13.2791;84.8469;96.7058;433.686 1413.32;49.4216;13.8374;101.065;216.573;280.185;1425.48 4 299270;24404;24890;24207 SERPINA6_32325;GPX1_33050;ESR1_33192;APOC3_32553 12.2984075 10.272310000000001 9.813470548150892 3.9401275 3.22471 3.0195948667812478 47.0086525 38.2611 41.4801933910032 25.7745;8.00432;12.5403;2.87451 8.17372;2.69961;3.74981;1.13737 103.274;25.2254;51.2968;8.23841 0 Exp 4,2(0.19);Exp 5,1(0.1);Hill,4(0.37);Linear,2(0.19);Poly 2,2(0.19) 1.9658584137433062 23.35838258266449 1.5235437154769897 5.5128583908081055 1.1423888040729715 1.7603585720062256 2.5613404399232422 305.8792050146222 -1.713834439539042 198.1123289849936 14.546645885944201 655.9836468413284 UP 0.6363636363636364 0.36363636363636365 0.0 GO:0010558 7 negative regulation of macromolecule biosynthetic process 265 277 12 12 8 7 4 4 65 273 2205 0.11414 0.95266 0.23666 1.44 259241;24426;25283;24890 nr1d2;gstp1;gclc;esr1 NR1D2_9358;GSTP1_8762;GCLC_8699;ESR1_33192 72.6181775 67.52714999999999 9.46041 71.80199075181707 47.3786411256335 67.93204951919972 46.8789525 44.298355 2.2133 50.92289339510301 28.55539778607629 47.54581881354797 149.3691 133.9349 49.4216 117.24169146334705 111.13171836045167 113.54909622649568 9.46041;122.514;145.958;12.5403 2.2133;84.8469;96.7058;3.74981 49.4216;216.573;280.185;51.2968 3 1 3 259241;24426;25283 NR1D2_9358;GSTP1_8762;GCLC_8699 92.64413666666667 122.514 72.98667392487505 61.25533333333334 84.8469 51.474553445399934 182.05986666666664 216.573 119.1902008315002 9.46041;122.514;145.958 2.2133;84.8469;96.7058 49.4216;216.573;280.185 1 24890 ESR1_33192 12.5403 12.5403 3.74981 3.74981 51.2968 51.2968 12.5403 3.74981 51.2968 0 Hill,2(0.5);Poly 2,2(0.5) 2.459447988573374 11.182083368301392 1.7318620681762695 5.5128583908081055 1.8229478812339703 1.9686814546585083 2.252226563219267 142.98412843678074 -3.0254830272009485 96.78338802720094 34.47224236591988 264.2659576340801 UP 0.75 0.25 0.0 GO:0046890 6 regulation of lipid biosynthetic process 73 78 10 10 8 5 3 3 66 75 2403 0.84125 0.35465 0.46818 3.85 64194;25317;24207 insig1;fgf1;apoc3 INSIG1_8906;FGF1_8633;APOC3_32553 238.23063666666667 37.6554 2.87451 377.9279597099718 237.154467652952 381.5739290537597 150.67949000000002 13.2791 1.13737 248.57364791078177 150.95578161108017 250.13177574398713 524.7678033333333 101.065 8.23841 815.5866794456773 520.815676014471 824.8301266330072 37.6554;674.162;2.87451 13.2791;437.622;1.13737 101.065;1465.0;8.23841 2 1 2 64194;25317 INSIG1_8906;FGF1_8633 355.9087 355.9087 450.0781331299934 225.45055000000002 225.45055000000002 300.055742138365 783.0325 783.0325 964.4476875976737 37.6554;674.162 13.2791;437.622 101.065;1465.0 1 24207 APOC3_32553 2.87451 2.87451 1.13737 1.13737 8.23841 8.23841 2.87451 1.13737 8.23841 0 Exp 4,1(0.34);Exp 5,1(0.34);Linear,1(0.34) 1.6756771137429767 5.06049382686615 1.5235437154769897 1.9665359258651733 0.2433623404849805 1.5704141855239868 -189.43510950809628 665.8963828414296 -130.60807256808476 431.96705256808474 -398.1554069605189 1447.6910136271858 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0002252 3 immune effector process 125 137 4 4 4 2 2 2 67 135 2343 0.27166 0.89477 0.58408 1.46 84586;117517 fgl2;c7 FGL2_32918;C7_8179 125.132 125.132 103.858 30.08597932592525 108.24236541906289 18.29334959609164 64.1735 64.1735 32.7314 44.4658442494911 39.21131237861789 27.03682087690482 309.43600000000004 309.43600000000004 293.781 22.139513318950105 297.00734392382395 13.461614549534982 146.406;103.858 95.6156;32.7314 325.091;293.781 0 2 0 2 84586;117517 FGL2_32918;C7_8179 125.132 125.132 30.08597932592525 64.1735 64.1735 44.4658442494911 309.43600000000004 309.43600000000004 22.139513318950105 146.406;103.858 95.6156;32.7314 325.091;293.781 0 Hill,1(0.5);Poly 2,1(0.5) 1.7899426607688733 3.590162515640259 1.6593536138534546 1.9308089017868042 0.1919478748866183 1.7950812578201294 83.43496 166.82904000000002 2.546984000000016 125.800016 278.7522 340.11980000000005 DOWN 0.0 1.0 0.0 GO:0048856 3 anatomical structure development 699 756 44 44 38 28 22 22 47 734 1744 0.70927 0.38669 0.68957 2.91 308843;360243;192247;94195;58835;24614;338475;312538;59107;64194;29200;360504;24426;24404;25317;24890;25315;24309;25426;24296;25612;25748 tsku;top2a;sez6;s100a9;phgdh;orm1;nrep;mcm2;ltbp1;insig1;inhba;hba-a2;gstp1;gpx1;fgf1;esr1;ephx1;dbp;cyp1b1;cyp1a1;asns;alas2 TSKU_10094;TOP2A_10059;SEZ6_9819;S100A9_9775;PHGDH_9470;ORM1_9400;NREP_9364;MCM2_9206;LTBP1_33264;INSIG1_8906;INHBA_33300;HBA2_32600;GSTP1_8762;GPX1_33050;FGF1_8633;ESR1_33192;EPHX1_8567;DBP_8439;CYP1B1_32710;CYP1A1_8415;ASNS_8091;ALAS2_8019 201.4160831818184 92.05505 4.48597E-12 284.8346885274862 153.59195179053228 225.2802139285218 134.30160422727292 56.056749999999994 4.48597E-12 207.12140266860598 100.59559155034509 158.7289275686096 410.4120227272729 201.75150000000002 4.48599E-12 592.4162186836459 315.35771805578537 471.10890445290124 92.2997;4.48597E-12;10.6392;963.318;122.826;662.49;191.159;3.76863;769.394;37.6554;91.8104;131.05;122.514;8.00432;674.162;12.5403;27.5708;66.0377;229.313;83.0393;6.05608;125.506 49.0864;4.48597E-12;3.96047;802.143;67.6778;432.445;115.886;0.956203;438.027;13.2791;44.1594;88.5948;84.8469;2.69961;437.622;3.74981;12.6303;19.9899;185.32;63.0271;2.7438;85.7907 185.899;4.48599E-12;29.4997;1158.68;246.456;1413.32;448.068;22.9217;2211.2;101.065;186.93;254.163;216.573;25.2254;1465.0;51.2968;61.9858;280.428;299.27;119.986;14.3351;236.762 14 8 14 308843;360243;94195;58835;24614;312538;64194;24426;25317;25315;24309;25426;24296;25612 TSKU_10094;TOP2A_10059;S100A9_9775;PHGDH_9470;ORM1_9400;MCM2_9206;INSIG1_8906;GSTP1_8762;FGF1_8633;EPHX1_8567;DBP_8439;CYP1B1_32710;CYP1A1_8415;ASNS_8091 220.78932928571462 87.6695 309.28988562681315 155.12625021428605 56.056749999999994 238.31225598292312 398.99425714285746 201.236 526.0211384560519 92.2997;4.48597E-12;963.318;122.826;662.49;3.76863;37.6554;122.514;674.162;27.5708;66.0377;229.313;83.0393;6.05608 49.0864;4.48597E-12;802.143;67.6778;432.445;0.956203;13.2791;84.8469;437.622;12.6303;19.9899;185.32;63.0271;2.7438 185.899;4.48599E-12;1158.68;246.456;1413.32;22.9217;101.065;216.573;1465.0;61.9858;280.428;299.27;119.986;14.3351 8 192247;338475;59107;29200;360504;24404;24890;25748 SEZ6_9819;NREP_9364;LTBP1_33264;INHBA_33300;HBA2_32600;GPX1_33050;ESR1_33192;ALAS2_8019 167.5129025 108.6582 252.33589841681732 97.85847375 64.97505 144.3622132698876 430.3931125 211.846 733.6796047743561 10.6392;191.159;769.394;91.8104;131.05;8.00432;12.5403;125.506 3.96047;115.886;438.027;44.1594;88.5948;2.69961;3.74981;85.7907 29.4997;448.068;2211.2;186.93;254.163;25.2254;51.2968;236.762 0 Exp 2,1(0.05);Exp 4,3(0.14);Exp 5,1(0.05);Hill,8(0.37);Linear,3(0.14);Poly 2,6(0.28) 2.3045833502119955 55.788352966308594 1.5140434503555298 6.292444229125977 1.3023749879009623 1.9253200888633728 82.39124229332342 320.4409240703134 47.75107864108266 220.8521298134632 162.85704080736392 657.9670046471821 UP 0.6363636363636364 0.36363636363636365 0.0 GO:0060135 4 maternal process involved in female pregnancy 17 18 2 2 2 2 2 2 67 16 2462 0.9884 0.083748 0.083748 11.11 24890;25748 esr1;alas2 ESR1_33192;ALAS2_8019 69.02315 69.02315 12.5403 79.87881251148518 47.97697331625574 74.12652414782605 44.770255 44.770255 3.74981 58.01166965357962 29.485552951222115 53.83409312467538 144.0294 144.0294 51.2968 131.14370059411925 109.4761385420002 121.69968960827391 0.0 12.5403 0.5 69.02315 12.5403;125.506 3.74981;85.7907 51.2968;236.762 0 2 0 2 24890;25748 ESR1_33192;ALAS2_8019 69.02315 69.02315 79.87881251148518 44.770255 44.770255 58.01166965357962 144.0294 144.0294 131.14370059411925 12.5403;125.506 3.74981;85.7907 51.2968;236.762 0 Hill,1(0.5);Poly 2,1(0.5) 1.7451953237701385 3.4904932975769043 1.7318620681762695 1.7586312294006348 0.018928655428424642 1.7452466487884521 -41.68323599999998 179.729536 -35.62981719999999 125.1703272 -37.72649599999997 325.785296 DOWN 0.0 1.0 0.0 GO:0048519 4 negative regulation of biological process 1024 1094 58 57 47 34 26 26 43 1068 1410 0.22038 0.84622 0.39071 2.38 308843;360243;192247;299270;287877;24614;259241;316351;24567;312538;59107;24539;288001;64194;29200;24426;24404;29739;25283;84586;24890;25426;310395;25612;24207;114628 tsku;top2a;sez6;serpina6;pycr1;orm1;nr1d2;npas2;mt1;mcm2;ltbp1;lpl;kng1;insig1;inhba;gstp1;gpx1;gclm;gclc;fgl2;esr1;cyp1b1;noct;asns;apoc3;abcg5 TSKU_10094;TOP2A_10059;SEZ6_9819;SERPINA6_32325;PYCR1_9631;ORM1_9400;NR1D2_9358;NPAS2_9350;MT1A_9255;MCM2_9206;LTBP1_33264;LPL_32544;KNG1L1_32433;INSIG1_8906;INHBA_33300;GSTP1_8762;GPX1_33050;GCLM_8700;GCLC_8699;FGL2_32918;ESR1_33192;CYP1B1_32710;CCRN4L_8232;ASNS_8091;APOC3_32553;ABCG5_7947 288001(0.1788) 219.45490038461554 92.05505 4.48597E-12 297.1369190378145 182.915994684516 259.4626615012424 134.17372280769249 46.6229 4.48597E-12 185.0244829593598 115.26151609564748 165.32747966461244 514.5899273076925 201.04000000000002 4.48599E-12 815.6465222455889 412.7102439656432 699.5793050356208 92.2997;4.48597E-12;10.6392;25.7745;132.668;662.49;9.46041;53.0014;818.334;3.76863;769.394;900.118;3.87556;37.6554;91.8104;122.514;8.00432;190.233;145.958;146.406;12.5403;229.313;665.276;6.05608;2.87451;565.363 49.0864;4.48597E-12;3.96047;8.17372;90.3184;432.445;2.2133;14.3825;540.216;0.956203;438.027;487.466;1.25511;13.2791;44.1594;84.8469;2.69961;69.2223;96.7058;95.6156;3.74981;185.32;433.686;2.7438;1.13737;386.851 185.899;4.48599E-12;29.4997;103.274;239.858;1413.32;49.4216;215.15;988.495;22.9217;2211.2;3428.38;13.8374;101.065;186.93;216.573;25.2254;496.452;280.185;325.091;51.2968;299.27;1425.48;14.3351;8.23841;1047.94 14 12 14 308843;360243;287877;24614;259241;312538;288001;64194;24426;29739;25283;25426;310395;25612 TSKU_10094;TOP2A_10059;PYCR1_9631;ORM1_9400;NR1D2_9358;MCM2_9206;KNG1L1_32433;INSIG1_8906;GSTP1_8762;GCLM_8700;GCLC_8699;CYP1B1_32710;CCRN4L_8232;ASNS_8091 164.3976985714289 107.40684999999999 224.61805776247436 104.43416521428603 59.15435 149.0600481056653 339.9012714285717 201.236 478.7090277541805 92.2997;4.48597E-12;132.668;662.49;9.46041;3.76863;3.87556;37.6554;122.514;190.233;145.958;229.313;665.276;6.05608 49.0864;4.48597E-12;90.3184;432.445;2.2133;0.956203;1.25511;13.2791;84.8469;69.2223;96.7058;185.32;433.686;2.7438 185.899;4.48599E-12;239.858;1413.32;49.4216;22.9217;13.8374;101.065;216.573;496.452;280.185;299.27;1425.48;14.3351 12 192247;299270;316351;24567;59107;24539;29200;24404;84586;24890;24207;114628 SEZ6_9819;SERPINA6_32325;NPAS2_9350;MT1A_9255;LTBP1_33264;LPL_32544;INHBA_33300;GPX1_33050;FGL2_32918;ESR1_33192;APOC3_32553;ABCG5_7947 283.6883025 72.4059 364.2447835858494 168.86987333333332 29.27095 221.60114800850116 718.3933591666668 201.04000000000002 1075.6484328508593 10.6392;25.7745;53.0014;818.334;769.394;900.118;91.8104;8.00432;146.406;12.5403;2.87451;565.363 3.96047;8.17372;14.3825;540.216;438.027;487.466;44.1594;2.69961;95.6156;3.74981;1.13737;386.851 29.4997;103.274;215.15;988.495;2211.2;3428.38;186.93;25.2254;325.091;51.2968;8.23841;1047.94 0 Exp 2,2(0.08);Exp 4,3(0.12);Exp 5,1(0.04);Hill,11(0.43);Linear,4(0.16);Poly 2,5(0.2) 2.097789697832406 58.043047070503235 1.5140434503555298 5.5128583908081055 0.9347508782178656 1.7841069102287292 105.23914581423075 333.6706549550003 63.05260125998883 205.29484435539615 201.0654978875491 828.1143567278357 CONFLICT 0.5384615384615384 0.46153846153846156 0.0 GO:0045944 9 positive regulation of transcription by RNA polymerase II 241 260 13 13 12 9 8 8 61 252 2226 0.73246 0.40786 0.68565 3.08 360243;259241;316351;64194;29200;25317;24890;24309 top2a;nr1d2;npas2;insig1;inhba;fgf1;esr1;dbp TOP2A_10059;NR1D2_9358;NPAS2_9350;INSIG1_8906;INHBA_33300;FGF1_8633;ESR1_33192;DBP_8439 118.08345125000056 45.3284 4.48597E-12 226.84442559766376 135.7706796193435 251.41523727348468 66.92450125000056 13.8308 4.48597E-12 150.44396357299357 79.48500916597901 166.5420671687884 293.6614250000006 143.9975 4.48599E-12 482.77308197856155 332.7707614710685 534.1534891141862 4.48597E-12;9.46041;53.0014;37.6554;91.8104;674.162;12.5403;66.0377 4.48597E-12;2.2133;14.3825;13.2791;44.1594;437.622;3.74981;19.9899 4.48599E-12;49.4216;215.15;101.065;186.93;1465.0;51.2968;280.428 5 3 5 360243;259241;64194;25317;24309 TOP2A_10059;NR1D2_9358;INSIG1_8906;FGF1_8633;DBP_8439 157.4631020000009 37.6554 289.99554570480245 94.6208600000009 13.2791 191.9168494713343 379.18292000000093 101.065 616.1621251458346 4.48597E-12;9.46041;37.6554;674.162;66.0377 4.48597E-12;2.2133;13.2791;437.622;19.9899 4.48599E-12;49.4216;101.065;1465.0;280.428 3 316351;29200;24890 NPAS2_9350;INHBA_33300;ESR1_33192 52.450700000000005 53.0014 39.637919236130436 20.76390333333333 14.3825 20.94696809490656 151.1256 186.93 87.59813971814702 53.0014;91.8104;12.5403 14.3825;44.1594;3.74981 215.15;186.93;51.2968 0 Exp 4,1(0.13);Exp 5,1(0.13);Hill,5(0.63);Linear,1(0.13) 1.978868492449429 16.035176634788513 1.5704141855239868 2.6413023471832275 0.3497084122628379 1.934571921825409 -39.11171573218519 275.2786182321863 -37.3278466444242 171.17684914442532 -40.883252640541855 628.206102640543 UP 0.625 0.375 0.0 GO:0006641 7 triglyceride metabolic process 19 21 4 4 4 4 4 4 65 17 2461 0.99982 0.002085 0.002085 19.05 24539;64194;24404;24207 lpl;insig1;gpx1;apoc3 LPL_32544;INSIG1_8906;GPX1_33050;APOC3_32553 237.1630575 22.82986 2.87451 442.2357635351568 142.0655048017358 360.9737628742707 126.14552 7.989355 1.13737 240.94069000011697 74.79404363643602 196.4014963871076 890.7272025 63.1452 8.23841 1692.2497800005358 529.3233561776416 1379.820092655396 0.5 5.439415 1.5 22.82986 900.118;37.6554;8.00432;2.87451 487.466;13.2791;2.69961;1.13737 3428.38;101.065;25.2254;8.23841 1 3 1 64194 INSIG1_8906 37.6554 37.6554 13.2791 13.2791 101.065 101.065 37.6554 13.2791 101.065 3 24539;24404;24207 LPL_32544;GPX1_33050;APOC3_32553 303.66561 8.00432 516.5492898941911 163.76766 2.69961 280.3320738651236 1153.9479366666667 25.2254 1969.7342580907602 900.118;8.00432;2.87451 487.466;2.69961;1.13737 3428.38;25.2254;8.23841 0 Exp 2,1(0.25);Exp 4,1(0.25);Exp 5,1(0.25);Hill,1(0.25) 1.7372894866783208 6.978373289108276 1.5235437154769897 1.9665359258651733 0.1838484966529457 1.7441468238830566 -196.2279907644537 670.5541057644537 -109.97635620011462 362.2673962001146 -767.6775819005252 2549.131986900525 DOWN 0.25 0.75 0.0 GO:0016043 4 cellular component organization 805 877 43 42 38 21 19 19 50 858 1620 0.13634 0.91362 0.24891 2.17 83472;308843;360243;192247;94195;58835;338475;29685;312538;24539;293502;29739;25283;499709;25426;310395;24207;301111;114628 ugdh;tsku;top2a;sez6;s100a9;phgdh;nrep;mcm6;mcm2;lpl;kif22;gclm;gclc;gar1;cyp1b1;noct;apoc3;ano10;abcg5 UGDH_10131;TSKU_10094;TOP2A_10059;SEZ6_9819;S100A9_9775;PHGDH_9470;NREP_9364;MCM6_9210;MCM2_9206;LPL_32544;KIF22_8963;GCLM_8700;GCLC_8699;GAR1_8683;CYP1B1_32710;CCRN4L_8232;APOC3_32553;ANO10_8049;ABCG5_7947 499709(-0.07184) 258.9806950526318 122.826 4.48597E-12 332.1513524171999 211.99179945279815 281.5386578548588 174.54049321052656 67.6778 4.48597E-12 242.00091056674478 139.19636763615873 193.08475304764357 559.0494094736845 246.456 4.48599E-12 845.7554667033064 458.4454891486734 734.0578772119301 59.3662;92.2997;4.48597E-12;10.6392;963.318;122.826;191.159;1.87441;3.76863;900.118;0.961856;190.233;145.958;765.364;229.313;665.276;2.87451;9.9207;565.363 25.4417;49.0864;4.48597E-12;3.96047;802.143;67.6778;115.886;0.496857;0.956203;487.466;0.281971;69.2223;96.7058;587.034;185.32;433.686;1.13737;2.9165;386.851 135.068;185.899;4.48599E-12;29.4997;1158.68;246.456;448.068;9.53;22.9217;3428.38;4.47267;496.452;280.185;1362.21;299.27;1425.48;8.23841;33.1883;1047.94 14 5 14 83472;308843;360243;94195;58835;29685;312538;293502;29739;25283;499709;25426;310395;301111 UGDH_10131;TSKU_10094;TOP2A_10059;S100A9_9775;PHGDH_9470;MCM6_9210;MCM2_9206;KIF22_8963;GCLM_8700;GCLC_8699;GAR1_8683;CYP1B1_32710;CCRN4L_8232;ANO10_8049 232.17710685714317 107.56285 320.9352324519896 165.78346650000032 58.3821 255.3250830597333 404.27233357142893 216.1775 516.7839745577872 59.3662;92.2997;4.48597E-12;963.318;122.826;1.87441;3.76863;0.961856;190.233;145.958;765.364;229.313;665.276;9.9207 25.4417;49.0864;4.48597E-12;802.143;67.6778;0.496857;0.956203;0.281971;69.2223;96.7058;587.034;185.32;433.686;2.9165 135.068;185.899;4.48599E-12;1158.68;246.456;9.53;22.9217;4.47267;496.452;280.185;1362.21;299.27;1425.48;33.1883 5 192247;338475;24539;24207;114628 SEZ6_9819;NREP_9364;LPL_32544;APOC3_32553;ABCG5_7947 334.03074200000003 191.159 390.0731570337247 199.060168 115.886 225.05476492689326 992.4252220000001 448.068 1425.5816004367018 10.6392;191.159;900.118;2.87451;565.363 3.96047;115.886;487.466;1.13737;386.851 29.4997;448.068;3428.38;8.23841;1047.94 0 Exp 2,2(0.11);Exp 4,4(0.22);Hill,7(0.37);Linear,3(0.16);Poly 2,3(0.16) 1.9464934714350177 38.46116244792938 1.5235437154769897 3.747737169265747 0.6563841408544042 1.7603585720062256 109.62723236168449 408.3341577435791 65.72361288029926 283.3573735407539 178.75137177887854 939.3474471684901 UP 0.7368421052631579 0.2631578947368421 0.0 GO:0009615 5 response to virus 66 68 5 5 5 2 2 2 67 66 2412 0.72061 0.55624 0.70687 2.94 170496;24296 lcn2;cyp1a1 LCN2_32481;CYP1A1_8415 527.83265 527.83265 83.0393 629.032788023363 349.03838992332965 575.9752369118979 307.47905000000003 307.47905000000003 63.0271 345.7072630385497 209.21632749178536 316.54760534262806 2102.2780000000002 2102.2780000000002 119.986 2803.384230983687 1305.4530668127056 2566.924852470389 972.626;83.0393 551.931;63.0271 4084.57;119.986 2 0 2 170496;24296 LCN2_32481;CYP1A1_8415 527.83265 527.83265 629.032788023363 307.47905000000003 307.47905000000003 345.7072630385497 2102.2780000000002 2102.2780000000002 2803.384230983687 972.626;83.0393 551.931;63.0271 4084.57;119.986 0 0 Linear,1(0.5);Poly 2,1(0.5) 3.4183346650857755 8.14943516254425 1.856990933418274 6.292444229125977 3.1363391030311374 4.074717581272125 -343.96231599999976 1399.6276159999998 -171.64677199999994 786.604872 -1783.0143199999993 5987.57032 UP 1.0 0.0 0.0 GO:0046686 6 response to cadmium ion 39 43 4 4 3 4 3 3 66 40 2438 0.9725 0.10897 0.10897 6.98 24567;116686;25283 mt1;gsr;gclc MT1A_9255;GSR_8755;GCLC_8699 344.6146333333333 145.958 69.5519 412.0279138548787 179.58512622821544 274.12495689785874 226.0078 96.7058 41.1016 273.5288859971465 116.28303211103226 182.40614265319132 464.29733333333337 280.185 124.212 460.61837727812525 277.852637489157 314.0975327375112 1.5 482.14599999999996 818.334;69.5519;145.958 540.216;41.1016;96.7058 988.495;124.212;280.185 2 1 2 116686;25283 GSR_8755;GCLC_8699 107.75495000000001 107.75495000000001 54.02727143401748 68.9037 68.9037 39.31810688245302 202.1985 202.1985 110.28956598200936 69.5519;145.958 41.1016;96.7058 124.212;280.185 1 24567 MT1A_9255 818.334 818.334 540.216 540.216 988.495 988.495 818.334 540.216 988.495 0 Exp 4,1(0.34);Poly 2,2(0.67) 1.9537255753925384 5.910118103027344 1.7603585720062256 2.3371741771698 0.31901862867571024 1.8125853538513184 -121.63884354306481 810.8681102097314 -83.51927288471842 535.5348728847184 -56.94142913248652 985.5360957991531 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0050810 7 regulation of steroid biosynthetic process 33 36 6 6 6 2 2 2 67 34 2444 0.92807 0.25485 0.25485 5.56 64194;25317 insig1;fgf1 INSIG1_8906;FGF1_8633 355.9087 355.9087 37.6554 450.0781331299934 409.1163044246474 443.7434253986875 225.45055000000002 225.45055000000002 13.2791 300.055742138365 260.9227181811433 295.8325522305859 783.0325 783.0325 101.065 964.4476875976737 897.0481503340759 950.8733906626555 0.5 355.9087 37.6554;674.162 13.2791;437.622 101.065;1465.0 2 0 2 64194;25317 INSIG1_8906;FGF1_8633 355.9087 355.9087 450.0781331299934 225.45055000000002 225.45055000000002 300.055742138365 783.0325 783.0325 964.4476875976737 37.6554;674.162 13.2791;437.622 101.065;1465.0 0 0 Exp 5,1(0.5);Linear,1(0.5) 1.757349115662911 3.53695011138916 1.5704141855239868 1.9665359258651733 0.2801003687706698 1.76847505569458 -267.867768 979.685168 -190.40549199999995 641.3065919999999 -553.6237999999998 2119.6888 UP 1.0 0.0 0.0 GO:0044260 4 cellular macromolecule metabolic process 676 733 34 33 30 22 19 19 50 714 1764 0.46883 0.63672 0.89325 2.59 83472;360243;171497;94195;313108;29685;312538;293502;29200;24404;499709;24890;171142;298452;25426;310395;81508;25748;360887 ugdh;top2a;sgk2;s100a9;mms22l;mcm6;mcm2;kif22;inhba;gpx1;gar1;esr1;ehhadh;dph2;cyp1b1;noct;bhmt;alas2;coq8a UGDH_10131;TOP2A_10059;SGK2_32380;S100A9_9775;MMS22L_33129;MCM6_9210;MCM2_9206;KIF22_8963;INHBA_33300;GPX1_33050;GAR1_8683;ESR1_33192;EHHADH_8534;DPH2_8490;CYP1B1_32710;CCRN4L_8232;BHMT_8143;ALAS2_8019;ADCK3_7987 499709(-0.07184) 237.855414526316 91.8104 4.48597E-12 318.76189818781677 174.61056122137086 262.62863785001053 167.3985447894739 44.1594 4.48597E-12 240.02939588245812 118.49912638252914 185.27698406049737 447.7582668421055 186.93 4.48599E-12 581.3587377922761 351.4131263228084 533.9960802207739 59.3662;4.48597E-12;156.37;963.318;4.13516;1.87441;3.76863;0.961856;91.8104;8.00432;765.364;12.5403;166.899;734.134;229.313;665.276;5.5396;125.506;525.072 25.4417;4.48597E-12;100.616;802.143;1.24709;0.496857;0.956203;0.281971;44.1594;2.69961;587.034;3.74981;105.26;463.289;185.32;433.686;1.97501;85.7907;336.426 135.068;4.48599E-12;343.205;1158.68;20.8956;9.53;22.9217;4.47267;186.93;25.2254;1362.21;51.2968;384.658;1764.85;299.27;1425.48;37.8319;236.762;1038.12 11 8 11 83472;360243;171497;94195;313108;29685;312538;293502;499709;25426;310395 UGDH_10131;TOP2A_10059;SGK2_32380;S100A9_9775;MMS22L_33129;MCM6_9210;MCM2_9206;KIF22_8963;GAR1_8683;CYP1B1_32710;CCRN4L_8232 259.06793236363677 59.3662 360.37116473112644 194.29298372727314 25.4417 283.90061910921366 434.7029972727277 135.068 581.2214232406918 59.3662;4.48597E-12;156.37;963.318;4.13516;1.87441;3.76863;0.961856;765.364;229.313;665.276 25.4417;4.48597E-12;100.616;802.143;1.24709;0.496857;0.956203;0.281971;587.034;185.32;433.686 135.068;4.48599E-12;343.205;1158.68;20.8956;9.53;22.9217;4.47267;1362.21;299.27;1425.48 8 29200;24404;24890;171142;298452;81508;25748;360887 INHBA_33300;GPX1_33050;ESR1_33192;EHHADH_8534;DPH2_8490;BHMT_8143;ALAS2_8019;ADCK3_7987 208.6882025 108.6582 272.1699588373371 130.41869125 64.97505 174.09434422036628 465.70926249999997 211.846 621.1702666436104 91.8104;8.00432;12.5403;166.899;734.134;5.5396;125.506;525.072 44.1594;2.69961;3.74981;105.26;463.289;1.97501;85.7907;336.426 186.93;25.2254;51.2968;384.658;1764.85;37.8319;236.762;1038.12 0 Exp 2,2(0.11);Exp 4,3(0.16);Hill,7(0.37);Linear,3(0.16);Poly 2,4(0.22) 1.7925567068815762 34.60662305355072 1.5039241313934326 3.1843981742858887 0.3805382983009888 1.7318620681762695 94.5225847129627 381.18824433966927 59.46816557598575 275.32892400296214 186.3474975556556 709.1690361285553 CONFLICT 0.5789473684210527 0.42105263157894735 0.0 GO:1902531 6 regulation of intracellular signal transduction 377 399 20 20 14 12 7 7 62 392 2086 0.13067 0.93309 0.24102 1.75 192247;94195;24426;24404;25317;24890;24207 sez6;s100a9;gstp1;gpx1;fgf1;esr1;apoc3 SEZ6_9819;S100A9_9775;GSTP1_8762;GPX1_33050;FGF1_8633;ESR1_33192;APOC3_32553 256.29319 12.5403 2.87451 395.3953802900964 195.95437951727823 342.62345836733454 190.87988 3.96047 1.13737 312.81992465134397 133.92678182388258 247.198372421651 422.07333000000006 51.2968 8.23841 618.1764475243289 387.2515143527686 652.5056446156308 10.6392;963.318;122.514;8.00432;674.162;12.5403;2.87451 3.96047;802.143;84.8469;2.69961;437.622;3.74981;1.13737 29.4997;1158.68;216.573;25.2254;1465.0;51.2968;8.23841 3 4 3 94195;24426;25317 S100A9_9775;GSTP1_8762;FGF1_8633 586.6646666666667 674.162 427.176402800217 441.5373 437.622 358.66407814188744 946.7510000000001 1158.68 650.6365493599327 963.318;122.514;674.162 802.143;84.8469;437.622 1158.68;216.573;1465.0 4 192247;24404;24890;24207 SEZ6_9819;GPX1_33050;ESR1_33192;APOC3_32553 8.514582500000001 9.321760000000001 4.194885240197277 2.886815 3.22471 1.2901032192683914 28.5650775 27.36255 17.719401649924816 10.6392;8.00432;12.5403;2.87451 3.96047;2.69961;3.74981;1.13737 29.4997;25.2254;51.2968;8.23841 0 Exp 4,1(0.15);Hill,3(0.43);Linear,1(0.15);Poly 2,2(0.29) 2.213796102915233 17.576683402061462 1.5235437154769897 5.5128583908081055 1.5375154636776247 1.7318620681762695 -36.619806821593386 549.2061868215933 -40.860363216557516 422.6201232165575 -35.87819102188831 880.0248510218883 CONFLICT 0.42857142857142855 0.5714285714285714 0.0 GO:0032720 8 negative regulation of tumor necrosis factor production 19 19 3 3 2 3 2 2 67 17 2461 0.98649 0.092012 0.092012 10.53 24614;24426 orm1;gstp1 ORM1_9400;GSTP1_8762 392.502 392.502 122.514 381.8206912779871 459.49263184217835 369.88045471310255 258.64594999999997 258.64594999999997 84.8469 245.7889736375597 301.76974873575995 238.10269953740615 814.9465 814.9465 216.573 846.227919064657 963.4176129480412 819.7648127630507 0.0 122.514 0.5 392.502 662.49;122.514 432.445;84.8469 1413.32;216.573 2 0 2 24614;24426 ORM1_9400;GSTP1_8762 392.502 392.502 381.8206912779871 258.64594999999997 258.64594999999997 245.7889736375597 814.9465 814.9465 846.227919064657 662.49;122.514 432.445;84.8469 1413.32;216.573 0 0 Linear,1(0.5);Poly 2,1(0.5) 2.922023451671041 7.061641335487366 1.5487829446792603 5.5128583908081055 2.803024629092795 3.530820667743683 -136.67447999999996 921.67848 -82.00018799999998 599.2920879999999 -357.86555999999973 1987.7585599999998 UP 1.0 0.0 0.0 GO:0043524 8 negative regulation of neuron apoptotic process 75 76 3 3 3 3 3 3 66 73 2405 0.85153 0.33958 0.45972 3.95 24567;29739;25283 mt1;gclm;gclc MT1A_9255;GCLM_8700;GCLC_8699 384.8416666666667 190.233 145.958 376.0675088336312 245.155426169527 258.07902017735836 235.38136666666665 96.7058 69.2223 264.35194524092935 136.749675555362 181.4678518240015 588.3773333333334 496.452 280.185 362.99237485976664 460.6526972732817 267.2088223299948 818.334;190.233;145.958 540.216;69.2223;96.7058 988.495;496.452;280.185 2 1 2 29739;25283 GCLM_8700;GCLC_8699 168.09550000000002 168.09550000000002 31.30715273703435 82.96405 82.96405 19.433769220740455 388.3185 388.3185 152.9238622468713 190.233;145.958 69.2223;96.7058 496.452;280.185 1 24567 MT1A_9255 818.334 818.334 540.216 540.216 988.495 988.495 818.334 540.216 988.495 0 Hill,1(0.34);Poly 2,2(0.67) 1.987697513527451 6.006325006484985 1.7603585720062256 2.3371741771698 0.29951624067163996 1.90879225730896 -40.71878115212854 810.4021144854619 -63.761020154810865 534.5237534881442 177.6127924687604 999.1418741979063 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0034371 9 chylomicron remodeling 2 2 1 1 1 1 1 1 68 1 2477 0.99928 0.053458 0.053458 50.0 24539 lpl LPL_32544 900.118 900.118 900.118 900.118 487.466 487.466 487.466 487.466 3428.38 3428.38 3428.38 3428.38 0.0 900.118 0.0 900.118 900.118 487.466 3428.38 0 1 0 1 24539 LPL_32544 900.118 900.118 487.466 487.466 3428.38 3428.38 900.118 487.466 3428.38 0 Exp 2,1(1) 1.7036563158035278 1.7036563158035278 1.7036563158035278 1.7036563158035278 0.0 1.7036563158035278 900.118 900.118 487.466 487.466 3428.38 3428.38 DOWN 0.0 1.0 0.0 GO:1901423 6 response to benzene 3 3 1 1 1 1 1 1 68 2 2476 0.99787 0.07912 0.07912 33.33 25748 alas2 ALAS2_8019 125.506 125.506 125.506 125.50600000000001 85.7907 85.7907 85.7907 85.7907 236.762 236.762 236.762 236.76199999999997 0.0 125.506 0.0 125.506 125.506 85.7907 236.762 0 1 0 1 25748 ALAS2_8019 125.506 125.506 85.7907 85.7907 236.762 236.762 125.506 85.7907 236.762 0 Poly 2,1(1) 1.7586312294006348 1.7586312294006348 1.7586312294006348 1.7586312294006348 0.0 1.7586312294006348 125.506 125.506 85.7907 85.7907 236.762 236.762 DOWN 0.0 1.0 0.0 GO:0032270 7 positive regulation of cellular protein metabolic process 403 428 18 18 14 9 6 6 63 422 2056 0.040649 0.98344 0.072474 1.4 94195;29200;25283;25317;24890;25426 s100a9;inhba;gclc;fgf1;esr1;cyp1b1 S100A9_9775;INHBA_33300;GCLC_8699;FGF1_8633;ESR1_33192;CYP1B1_32710 352.8502833333334 187.63549999999998 12.5403 378.92760128625315 297.2846834414107 306.1631653587963 261.61666833333334 141.0129 3.74981 306.57669457120716 209.7006465443686 224.4420187553953 573.5603 289.72749999999996 51.2968 586.6133632468152 541.0163827929465 594.7105067776027 963.318;91.8104;145.958;674.162;12.5403;229.313 802.143;44.1594;96.7058;437.622;3.74981;185.32 1158.68;186.93;280.185;1465.0;51.2968;299.27 4 2 4 94195;25283;25317;25426 S100A9_9775;GCLC_8699;FGF1_8633;CYP1B1_32710 503.18775 451.7375 384.5224371870255 380.4477 311.471 316.05912513614703 800.78375 728.975 603.2722029257742 963.318;145.958;674.162;229.313 802.143;96.7058;437.622;185.32 1158.68;280.185;1465.0;299.27 2 29200;24890 INHBA_33300;ESR1_33192 52.17535 52.17535 56.052425255335734 23.954605 23.954605 28.573895113968096 119.1134 119.1134 95.90715547403126 91.8104;12.5403 44.1594;3.74981 186.93;51.2968 0 Hill,2(0.34);Linear,2(0.34);Poly 2,2(0.34) 1.9764754994449922 12.24515450000763 1.5704141855239868 3.1843981742858887 0.6130018798135921 1.7461103200912476 49.645054281350326 656.0555123853163 16.304221882009273 506.9291147846574 104.171850690812 1042.9487493091879 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0097305 5 response to alcohol 168 183 16 16 13 8 6 6 63 177 2301 0.77645 0.37594 0.63279 3.28 94195;29200;24426;116686;25426;54232 s100a9;inhba;gstp1;gsr;cyp1b1;car3 S100A9_9775;INHBA_33300;GSTP1_8762;GSR_8755;CYP1B1_32710;CAR3_8196 246.65943833333333 107.1622 3.44933 358.8339293864854 185.95714985386144 241.96901859972184 193.28372166666668 64.50315 2.13143 304.7845947699687 142.73074176378012 206.3257609208852 331.94768833333336 201.75150000000002 6.02113 416.7200097764479 257.7796805054895 281.52756963988475 963.318;91.8104;122.514;69.5519;229.313;3.44933 802.143;44.1594;84.8469;41.1016;185.32;2.13143 1158.68;186.93;216.573;124.212;299.27;6.02113 4 2 4 94195;24426;116686;25426 S100A9_9775;GSTP1_8762;GSR_8755;CYP1B1_32710 346.174225 175.9135 416.7600396172068 278.35287500000004 135.08345 354.37453855495295 449.68375000000003 257.9215 478.0419997297135 963.318;122.514;69.5519;229.313 802.143;84.8469;41.1016;185.32 1158.68;216.573;124.212;299.27 2 29200;54232 INHBA_33300;CAR3_8196 47.629865 47.629865 62.4807117898992 23.145415 23.145415 29.71826258650478 96.475565 96.475565 127.92188875379556 91.8104;3.44933 44.1594;2.13143 186.93;6.02113 0 Exp 4,2(0.34);Hill,1(0.17);Linear,1(0.17);Poly 2,2(0.34) 3.072306814127252 21.267115831375122 1.7056305408477783 6.759152412414551 2.111236323940421 2.7384445667266846 -40.46750460229458 533.7863812689611 -50.5947462914728 437.16218962480616 -1.4977655895721682 665.3931422562388 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0031349 6 positive regulation of defense response 74 79 4 4 3 4 3 3 66 76 2402 0.83602 0.36218 0.47253 3.8 94195;316351;24539 s100a9;npas2;lpl S100A9_9775;NPAS2_9350;LPL_32544 638.8124666666666 900.118 53.0014 508.31045077969173 738.3015160334458 434.0119283780136 434.66383333333334 487.466 14.3825 396.52579101942825 468.40811647352206 328.46299071270704 1600.7366666666667 1158.68 215.15 1651.5969031919785 2174.0711603344585 1692.8432804878807 963.318;53.0014;900.118 802.143;14.3825;487.466 1158.68;215.15;3428.38 1 2 1 94195 S100A9_9775 963.318 963.318 802.143 802.143 1158.68 1158.68 963.318 802.143 1158.68 2 316351;24539 NPAS2_9350;LPL_32544 476.5597 476.5597 599.0018923156922 250.92425 250.92425 334.5205509174661 1821.765 1821.765 2272.0967225120503 53.0014;900.118 14.3825;487.466 215.15;3428.38 0 Exp 2,1(0.34);Hill,1(0.34);Poly 2,1(0.34) 1.9725515250962098 6.050589203834534 1.7036563158035278 2.6413023471832275 0.5407811798527614 1.7056305408477783 63.60504251113878 1214.0198908221946 -14.047340150631271 883.375006817298 -268.22116996858995 3469.6945033019233 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0043207 4 response to external biotic stimulus 357 390 25 25 18 18 11 11 58 379 2099 0.63679 0.49384 0.86547 2.82 94195;361042;24614;24539;170496;360504;24426;24404;24296;310395;54232 s100a9;pck2;orm1;lpl;lcn2;hba-a2;gstp1;gpx1;cyp1a1;noct;car3 S100A9_9775;PCK2_9440;ORM1_9400;LPL_32544;LCN2_32481;HBA2_32600;GSTP1_8762;GPX1_33050;CYP1A1_8415;CCRN4L_8232;CAR3_8196 410.7784163636363 131.05 3.44933 418.18086519431176 307.95378272253555 388.78068386021096 268.2229809090909 88.5948 1.48195 280.79027441250804 194.62760095289678 244.79871953128813 1106.3946390909093 254.163 6.02113 1430.8151165056843 876.1246456324009 1363.0500223923439 963.318;6.67763;662.49;900.118;972.626;131.05;122.514;8.00432;83.0393;665.276;3.44933 802.143;1.48195;432.445;487.466;551.931;88.5948;84.8469;2.69961;63.0271;433.686;2.13143 1158.68;37.9425;1413.32;3428.38;4084.57;254.163;216.573;25.2254;119.986;1425.48;6.02113 7 4 7 94195;361042;24614;170496;24426;24296;310395 S100A9_9775;PCK2_9440;ORM1_9400;LCN2_32481;GSTP1_8762;CYP1A1_8415;CCRN4L_8232 496.56298999999996 662.49 418.6076596477754 338.50870714285713 432.445 297.8282615032032 1208.0787857142857 1158.68 1408.443452330795 963.318;6.67763;662.49;972.626;122.514;83.0393;665.276 802.143;1.48195;432.445;551.931;84.8469;63.0271;433.686 1158.68;37.9425;1413.32;4084.57;216.573;119.986;1425.48 4 24539;360504;24404;54232 LPL_32544;HBA2_32600;GPX1_33050;CAR3_8196 260.6554125 69.52716000000001 430.38645702745293 145.22296 45.647205 231.75068370009944 928.4473825 139.6942 1670.42935214236 900.118;131.05;8.00432;3.44933 487.466;88.5948;2.69961;2.13143 3428.38;254.163;25.2254;6.02113 0 Exp 2,1(0.1);Exp 4,1(0.1);Hill,2(0.19);Linear,3(0.28);Poly 2,4(0.37) 2.4406713813527965 32.39867877960205 1.528982162475586 6.759152412414551 2.1050609443585024 1.7846373319625854 163.64931747843465 657.9075152488381 102.28653267144082 434.159429146741 260.836939436065 1951.9523387457532 UP 0.6363636363636364 0.36363636363636365 0.0 GO:0035295 4 tube development 61 65 3 3 2 3 2 2 67 63 2415 0.74292 0.53151 0.69543 3.08 58835;24296 phgdh;cyp1a1 PHGDH_9470;CYP1A1_8415 102.93265 102.93265 83.0393 28.133445371034835 97.49423716673297 27.061745696737916 65.35245 65.35245 63.0271 3.2885415072639943 64.71674946279346 3.1632696532214775 183.221 183.221 119.986 89.42779461666264 165.93391484281736 86.02118241187237 122.826;83.0393 67.6778;63.0271 246.456;119.986 2 0 2 58835;24296 PHGDH_9470;CYP1A1_8415 102.93265 102.93265 28.133445371034835 65.35245 65.35245 3.2885415072639943 183.221 183.221 89.42779461666264 122.826;83.0393 67.6778;63.0271 246.456;119.986 0 0 Exp 4,1(0.5);Poly 2,1(0.5) 3.363453125771894 8.090285658836365 1.7978414297103882 6.292444229125977 3.1781641182068023 4.045142829418182 63.941684 141.92361599999998 60.794764 69.91013600000001 59.28040000000003 307.16159999999996 UP 1.0 0.0 0.0 GO:0060745 6 mammary gland branching involved in pregnancy 1 1 1 1 1 1 1 1 68 0 2478 1.0 0.027091 0.027091 100.0 24890 esr1 ESR1_33192 12.5403 12.5403 12.5403 12.540300000000002 3.74981 3.74981 3.74981 3.7498100000000005 51.2968 51.2968 51.2968 51.2968 0.0 12.5403 0.0 12.5403 12.5403 3.74981 51.2968 0 1 0 1 24890 ESR1_33192 12.5403 12.5403 3.74981 3.74981 51.2968 51.2968 12.5403 3.74981 51.2968 0 Hill,1(1) 1.7318620681762695 1.7318620681762695 1.7318620681762695 1.7318620681762695 0.0 1.7318620681762695 12.5403 12.5403 3.74981 3.74981 51.2968 51.2968 DOWN 0.0 1.0 0.0 GO:0060750 6 epithelial cell proliferation involved in mammary gland duct elongation 1 1 1 1 1 1 1 1 68 0 2478 1.0 0.027091 0.027091 100.0 24890 esr1 ESR1_33192 12.5403 12.5403 12.5403 12.540300000000002 3.74981 3.74981 3.74981 3.7498100000000005 51.2968 51.2968 51.2968 51.2968 0.0 12.5403 0.0 12.5403 12.5403 3.74981 51.2968 0 1 0 1 24890 ESR1_33192 12.5403 12.5403 3.74981 3.74981 51.2968 51.2968 12.5403 3.74981 51.2968 0 Hill,1(1) 1.7318620681762695 1.7318620681762695 1.7318620681762695 1.7318620681762695 0.0 1.7318620681762695 12.5403 12.5403 3.74981 3.74981 51.2968 51.2968 DOWN 0.0 1.0 0.0 GO:0009067 8 aspartate family amino acid biosynthetic process 9 9 3 3 3 3 3 3 66 6 2472 0.99994 0.0014225 0.0014225 33.33 81508;25612;296925 bhmt;asns;aass BHMT_8143;ASNS_8091;AASS_7936 5.802146666666666 5.81076 5.5396 0.2583477109117435 5.768030796360777 0.2253956338226096 2.4412333333333334 2.60489 1.97501 0.40969152350681015 2.42363657980456 0.3904513690537824 22.082066666666666 14.3351 14.0792 13.64035588697499 21.959638666741547 13.634678372117468 0.0 5.5396 0.0 5.5396 5.5396;6.05608;5.81076 1.97501;2.7438;2.60489 37.8319;14.3351;14.0792 1 2 1 25612 ASNS_8091 6.05608 6.05608 2.7438 2.7438 14.3351 14.3351 6.05608 2.7438 14.3351 2 81508;296925 BHMT_8143;AASS_7936 5.67518 5.67518 0.1917390747865672 2.28995 2.28995 0.4453924193337818 25.95555 25.95555 16.795695241489714 5.5396;5.81076 1.97501;2.60489 37.8319;14.0792 0 Exp 4,1(0.34);Hill,2(0.67) 2.4017775913453026 7.550020337104797 1.6724973917007446 3.5324413776397705 0.9417700022501402 2.3450815677642822 5.509798710605415 6.094494622727917 1.9776237310258555 2.9048429356408114 6.646550906019543 37.51758242731379 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0010556 6 regulation of macromolecule biosynthetic process 567 609 29 29 24 19 15 15 54 594 1884 0.39615 0.7106 0.77518 2.46 360243;94195;363465;259241;316351;64194;29200;24426;25283;25317;24890;298452;24309;25426;289185 top2a;s100a9;pir;nr1d2;npas2;insig1;inhba;gstp1;gclc;fgf1;esr1;dph2;dbp;cyp1b1;creg1 TOP2A_10059;S100A9_9775;PIR_9487;NR1D2_9358;NPAS2_9350;INSIG1_8906;INHBA_33300;GSTP1_8762;GCLC_8699;FGF1_8633;ESR1_33192;DPH2_8490;DBP_8439;CYP1B1_32710;CREG1_8380 225.986260666667 97.6763 4.48597E-12 304.0504118744334 207.8732556947981 276.3421705313702 150.72597400000032 44.1594 4.48597E-12 234.0621461592938 134.9791383164788 195.6467212299482 448.1844933333336 280.185 4.48599E-12 547.6163840628469 441.53758645563005 572.0747149263652 4.48597E-12;963.318;152.213;9.46041;53.0014;37.6554;91.8104;122.514;145.958;674.162;12.5403;734.134;66.0377;229.313;97.6763 4.48597E-12;802.143;56.4566;2.2133;14.3825;13.2791;44.1594;84.8469;96.7058;437.622;3.74981;463.289;19.9899;185.32;36.7323 4.48599E-12;1158.68;371.778;49.4216;215.15;101.065;186.93;216.573;280.185;1465.0;51.2968;1764.85;280.428;299.27;282.14 11 4 11 360243;94195;363465;259241;64194;24426;25283;25317;24309;25426;289185 TOP2A_10059;S100A9_9775;PIR_9487;NR1D2_9358;INSIG1_8906;GSTP1_8762;GCLC_8699;FGF1_8633;DBP_8439;CYP1B1_32710;CREG1_8380 227.11889181818225 122.514 307.0079483250551 157.75535454545496 56.4566 248.43592453657462 409.50369090909135 280.428 465.6422151334333 4.48597E-12;963.318;152.213;9.46041;37.6554;122.514;145.958;674.162;66.0377;229.313;97.6763 4.48597E-12;802.143;56.4566;2.2133;13.2791;84.8469;96.7058;437.622;19.9899;185.32;36.7323 4.48599E-12;1158.68;371.778;49.4216;101.065;216.573;280.185;1465.0;280.428;299.27;282.14 4 316351;29200;24890;298452 NPAS2_9350;INHBA_33300;ESR1_33192;DPH2_8490 222.87152500000002 72.4059 342.37475588741813 131.3951775 29.27095 221.9225817183552 554.5567 201.04000000000002 810.0260690312543 53.0014;91.8104;12.5403;734.134 14.3825;44.1594;3.74981;463.289 215.15;186.93;51.2968;1764.85 0 Exp 4,2(0.14);Exp 5,1(0.07);Hill,6(0.4);Linear,3(0.2);Poly 2,3(0.2) 2.110629945589944 33.683305978775024 1.5704141855239868 5.5128583908081055 1.0050121884855028 1.9026079177856445 72.11552227130122 379.85699906203274 32.27418491047213 269.1777630895284 171.05236628346483 725.3166203832025 UP 0.7333333333333333 0.26666666666666666 0.0 GO:0050729 7 positive regulation of inflammatory response 47 52 2 2 2 2 2 2 67 50 2428 0.83496 0.41448 0.65073 3.85 94195;24539 s100a9;lpl S100A9_9775;LPL_32544 931.7180000000001 931.7180000000001 900.118 44.68914857098584 920.5391699164345 41.79937219535322 644.8045 644.8045 487.466 222.51024058343975 589.1443621169916 208.12185196703658 2293.53 2293.53 1158.68 1604.9202612591064 2694.99504178273 1501.1397954397119 963.318;900.118 802.143;487.466 1158.68;3428.38 1 1 1 94195 S100A9_9775 963.318 963.318 802.143 802.143 1158.68 1158.68 963.318 802.143 1158.68 1 24539 LPL_32544 900.118 900.118 487.466 487.466 3428.38 3428.38 900.118 487.466 3428.38 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.704643142520658 3.409286856651306 1.7036563158035278 1.7056305408477783 0.0013959879163778321 1.704643428325653 869.7820000000002 993.654 336.42103999999995 953.18796 69.22400000000016 4517.835999999999 CONFLICT 0.5 0.5 0.0 GO:0044057 5 regulation of system process 160 167 6 6 6 2 2 2 67 165 2313 0.15775 0.94798 0.32045 1.2 29200;114628 inhba;abcg5 INHBA_33300;ABCG5_7947 328.5867 328.5867 91.8104 334.8522547085208 424.81960540770706 305.9485059891005 215.5052 215.5052 44.1594 242.31955421566792 285.1452111134767 221.40303534393937 617.4350000000001 617.4350000000001 186.93 608.8260096694293 792.4049904194165 556.2734174443885 91.8104;565.363 44.1594;386.851 186.93;1047.94 0 2 0 2 29200;114628 INHBA_33300;ABCG5_7947 328.5867 328.5867 334.8522547085208 215.5052 215.5052 242.31955421566792 617.4350000000001 617.4350000000001 608.8260096694293 91.8104;565.363 44.1594;386.851 186.93;1047.94 0 Hill,1(0.5);Linear,1(0.5) 2.022086292633966 4.0760674476623535 1.783576488494873 2.2924909591674805 0.35985687325656307 2.0380337238311768 -135.494848 792.668248 -120.33256799999998 551.3429679999999 -226.35479999999995 1461.2248 DOWN 0.0 1.0 0.0 GO:0018105 8 peptidyl-serine phosphorylation 56 56 1 1 1 1 1 1 68 55 2423 0.54792 0.78883 1.0 1.79 171497 sgk2 SGK2_32380 156.37 156.37 156.37 156.37 100.616 100.616 100.616 100.616 343.205 343.205 343.205 343.205 156.37 100.616 343.205 1 0 1 171497 SGK2_32380 156.37 156.37 100.616 100.616 343.205 343.205 156.37 100.616 343.205 0 0 Poly 2,1(1) 1.8997833728790283 1.8997833728790283 1.8997833728790283 1.8997833728790283 0.0 1.8997833728790283 156.37 156.37 100.616 100.616 343.205 343.205 UP 1.0 0.0 0.0 GO:0031326 6 regulation of cellular biosynthetic process 611 656 33 33 28 19 15 15 54 641 1837 0.26745 0.8185 0.48798 2.29 360243;94195;363465;259241;316351;64194;29200;25283;25317;24890;298452;24309;25426;289185;24207 top2a;s100a9;pir;nr1d2;npas2;insig1;inhba;gclc;fgf1;esr1;dph2;dbp;cyp1b1;creg1;apoc3 TOP2A_10059;S100A9_9775;PIR_9487;NR1D2_9358;NPAS2_9350;INSIG1_8906;INHBA_33300;GCLC_8699;FGF1_8633;ESR1_33192;DPH2_8490;DBP_8439;CYP1B1_32710;CREG1_8380;APOC3_32553 218.01029466666697 91.8104 4.48597E-12 308.4953398013093 185.84086960438526 270.8181720967658 145.145338666667 36.7323 4.48597E-12 236.72780954994965 120.50709021440703 190.87477249714973 434.2955206666669 280.185 4.48599E-12 556.4804563560391 395.66316573261423 561.1598635103226 4.48597E-12;963.318;152.213;9.46041;53.0014;37.6554;91.8104;145.958;674.162;12.5403;734.134;66.0377;229.313;97.6763;2.87451 4.48597E-12;802.143;56.4566;2.2133;14.3825;13.2791;44.1594;96.7058;437.622;3.74981;463.289;19.9899;185.32;36.7323;1.13737 4.48599E-12;1158.68;371.778;49.4216;215.15;101.065;186.93;280.185;1465.0;51.2968;1764.85;280.428;299.27;282.14;8.23841 10 5 10 360243;94195;363465;259241;64194;25283;25317;24309;25426;289185 TOP2A_10059;S100A9_9775;PIR_9487;NR1D2_9358;INSIG1_8906;GCLC_8699;FGF1_8633;DBP_8439;CYP1B1_32710;CREG1_8380 237.57938100000047 121.81715 321.54184134435656 165.04620000000045 46.59445 260.63104594315325 428.79676000000046 281.284 486.1735228061388 4.48597E-12;963.318;152.213;9.46041;37.6554;145.958;674.162;66.0377;229.313;97.6763 4.48597E-12;802.143;56.4566;2.2133;13.2791;96.7058;437.622;19.9899;185.32;36.7323 4.48599E-12;1158.68;371.778;49.4216;101.065;280.185;1465.0;280.428;299.27;282.14 5 316351;29200;24890;298452;24207 NPAS2_9350;INHBA_33300;ESR1_33192;DPH2_8490;APOC3_32553 178.872122 53.0014 312.4021325527547 105.343616 14.3825 200.82490754472272 445.29304199999996 186.93 742.832019490527 53.0014;91.8104;12.5403;734.134;2.87451 14.3825;44.1594;3.74981;463.289;1.13737 215.15;186.93;51.2968;1764.85;8.23841 0 Exp 4,3(0.2);Exp 5,1(0.07);Hill,6(0.4);Linear,3(0.2);Poly 2,2(0.14) 1.9372126715518634 29.69399130344391 1.5235437154769897 3.1843981742858887 0.45714457523329616 1.7603585720062256 61.890112378079294 374.1304769552546 25.344537774441108 264.9461395588928 152.67755411230627 715.9134872210277 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0042737 5 drug catabolic process 55 60 8 8 7 6 5 5 64 55 2423 0.99498 0.021727 0.021727 8.33 361042;287167;360504;24404;296925 pck2;hba-a1;hba-a2;gpx1;aass PCK2_9440;LOC287167_9118;HBA2_32600;GPX1_33050;AASS_7936 60.164941999999996 8.00432 5.81076 73.3187247699046 53.514679500843535 71.99700257788147 38.476729999999996 2.69961 1.48195 49.68017702565631 33.862875243017434 48.64415911481035 133.11242 37.9425 14.0792 149.9466453990952 121.4426139088986 148.1861666289347 2.0 8.00432 6.67763;149.282;131.05;8.00432;5.81076 1.48195;97.0024;88.5948;2.69961;2.60489 37.9425;334.152;254.163;25.2254;14.0792 1 4 1 361042 PCK2_9440 6.67763 6.67763 1.48195 1.48195 37.9425 37.9425 6.67763 1.48195 37.9425 4 287167;360504;24404;296925 LOC287167_9118;HBA2_32600;GPX1_33050;AASS_7936 73.53677 69.52716000000001 77.30119862440341 47.725425 45.647205 52.15909244207156 156.9049 139.6942 161.87890924469852 149.282;131.05;8.00432;5.81076 97.0024;88.5948;2.69961;2.60489 334.152;254.163;25.2254;14.0792 0 Hill,3(0.6);Poly 2,2(0.4) 1.8510576257402835 9.350117921829224 1.528982162475586 2.3450815677642822 0.3047141845405396 1.7846373319625854 -4.101753822768863 124.43163782276886 -5.069865161727606 82.0233251617276 1.6783902927102758 264.5464497072897 DOWN 0.2 0.8 0.0 GO:0015711 6 organic anion transport 106 111 11 10 7 7 3 3 66 108 2370 0.64578 0.58644 1.0 2.7 266730;24207;301111 slc17a3;apoc3;ano10 SLC17A3_9840;APOC3_32553;ANO10_8049 35.39303666666667 9.9207 2.87451 50.3449835732224 34.913872352295094 51.23350735752424 24.32635666666667 2.9165 1.13737 38.633973985245596 24.39935800604091 38.94442530766137 61.61490333333334 33.1883 8.23841 71.93354030593123 59.118242069928144 74.61855647786153 93.3839;2.87451;9.9207 68.9252;1.13737;2.9165 143.418;8.23841;33.1883 2 1 2 266730;301111 SLC17A3_9840;ANO10_8049 51.6523 51.6523 59.01739469952906 35.92085 35.92085 46.67519938730846 88.30315 88.30315 77.94416835815879 93.3839;9.9207 68.9252;2.9165 143.418;33.1883 1 24207 APOC3_32553 2.87451 2.87451 1.13737 1.13737 8.23841 8.23841 2.87451 1.13737 8.23841 0 Exp 4,1(0.34);Hill,1(0.34);Poly 2,1(0.34) 1.534077512701081 4.603102803230286 1.504341721534729 1.575217366218567 0.03665660413820579 1.5235437154769897 -21.57767537729393 92.36374871062726 -19.392100482616556 68.0448138159499 -19.785560431075382 143.01536709774206 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0006733 6 oxidoreduction coenzyme metabolic process 9 9 4 4 4 2 2 2 67 7 2471 0.99858 0.023028 0.023028 22.22 116682;360887 kynu;coq8a KYNU_8979;ADCK3_7987 312.7265 312.7265 100.381 300.301886008896 255.26552394209358 289.0980719434935 204.57455 204.57455 72.7231 186.46610880855803 168.89537143652564 179.50933727323604 599.7879999999999 599.7879999999999 161.456 619.8950592221236 481.17477505567933 596.7677020287005 0.0 100.381 0.0 100.381 100.381;525.072 72.7231;336.426 161.456;1038.12 0 2 0 2 116682;360887 KYNU_8979;ADCK3_7987 312.7265 312.7265 300.301886008896 204.57455 204.57455 186.46610880855803 599.7879999999999 599.7879999999999 619.8950592221236 100.381;525.072 72.7231;336.426 161.456;1038.12 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.762527636593318 3.5444716215133667 1.5869897603988647 1.957481861114502 0.2619774767920764 1.7722358107566833 -103.47068000000002 728.92368 -53.85429199999999 463.00339199999996 -259.3427199999999 1458.9187199999997 DOWN 0.0 1.0 0.0 GO:1901360 4 organic cyclic compound metabolic process 507 567 46 45 40 29 24 24 45 543 1935 0.99478 0.010887 0.017828 4.23 83472;360243;266730;299270;291317;287877;680308;313108;29685;312538;116682;293502;64194;84029;499709;24890;25315;25426;24296;310395;24207;25748;26760;296925 ugdh;top2a;slc17a3;serpina6;rpp38;pycr1;mthfd2;mms22l;mcm6;mcm2;kynu;kif22;insig1;hao2;gar1;esr1;ephx1;cyp1b1;cyp1a1;noct;apoc3;alas2;akr7a3;aass UGDH_10131;TOP2A_10059;SLC17A3_9840;SERPINA6_32325;RPP38_9741;PYCR1_9631;MTHFD2_9261;MMS22L_33129;MCM6_9210;MCM2_9206;KYNU_8979;KIF22_8963;INSIG1_8906;HAO2_8778;GAR1_8683;ESR1_33192;EPHX1_8567;CYP1B1_32710;CYP1A1_8415;CCRN4L_8232;APOC3_32553;ALAS2_8019;AKR7A3_8015;AASS_7936 499709(-0.07184) 171.44910108333352 58.24145 4.48597E-12 271.281840300581 134.7534089598324 238.4784295976467 123.64958379166687 29.254150000000003 4.48597E-12 209.02666139211541 97.84353040857268 185.5212906618626 300.38129916666685 111.63 4.48599E-12 456.50943239213325 228.12729449943166 386.02601455628974 59.3662;4.48597E-12;93.3839;25.7745;916.962;132.668;622.58;4.13516;1.87441;3.76863;100.381;0.961856;37.6554;140.856;765.364;12.5403;27.5708;229.313;83.0393;665.276;2.87451;125.506;57.1167;5.81076 25.4417;4.48597E-12;68.9252;8.17372;769.912;90.3184;414.266;1.24709;0.496857;0.956203;72.7231;0.281971;13.2791;93.5219;587.034;3.74981;12.6303;185.32;63.0271;433.686;1.13737;85.7907;33.0666;2.60489 135.068;4.48599E-12;143.418;103.274;1051.72;239.858;1250.29;20.8956;9.53;22.9217;161.456;4.47267;101.065;282.925;1362.21;51.2968;61.9858;299.27;119.986;1425.48;8.23841;236.762;102.949;14.0792 16 8 16 83472;360243;266730;287877;680308;313108;29685;312538;293502;64194;499709;25315;25426;24296;310395;26760 UGDH_10131;TOP2A_10059;SLC17A3_9840;PYCR1_9631;MTHFD2_9261;MMS22L_33129;MCM6_9210;MCM2_9206;KIF22_8963;INSIG1_8906;GAR1_8683;EPHX1_8567;CYP1B1_32710;CYP1A1_8415;CCRN4L_8232;AKR7A3_8015 174.00458475000028 58.24145 261.5773113437816 120.62353256250029 29.254150000000003 187.04928871500215 331.2124856250003 111.4675 511.31450695897934 59.3662;4.48597E-12;93.3839;132.668;622.58;4.13516;1.87441;3.76863;0.961856;37.6554;765.364;27.5708;229.313;83.0393;665.276;57.1167 25.4417;4.48597E-12;68.9252;90.3184;414.266;1.24709;0.496857;0.956203;0.281971;13.2791;587.034;12.6303;185.32;63.0271;433.686;33.0666 135.068;4.48599E-12;143.418;239.858;1250.29;20.8956;9.53;22.9217;4.47267;101.065;1362.21;61.9858;299.27;119.986;1425.48;102.949 8 299270;291317;116682;84029;24890;24207;25748;296925 SERPINA6_32325;RPP38_9741;KYNU_8979;HAO2_8778;ESR1_33192;APOC3_32553;ALAS2_8019;AASS_7936 166.33813375 63.07775 308.45338549780314 129.70168625000002 40.44841 261.77096246011536 238.71892625 132.365 343.50191695110453 25.7745;916.962;100.381;140.856;12.5403;2.87451;125.506;5.81076 8.17372;769.912;72.7231;93.5219;3.74981;1.13737;85.7907;2.60489 103.274;1051.72;161.456;282.925;51.2968;8.23841;236.762;14.0792 0 Exp 2,1(0.05);Exp 4,3(0.13);Exp 5,1(0.05);Hill,9(0.38);Linear,3(0.13);Poly 2,7(0.3) 2.04410201148638 53.38845705986023 1.504341721534729 6.292444229125977 1.1811545498004203 1.7616393566131592 62.91376049746263 279.9844416692043 40.02150216046097 207.27766542287276 117.73948771904432 483.0231106142894 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0055114 3 oxidation-reduction process 260 296 32 32 27 21 17 17 52 279 2199 0.99941 0.0016848 0.0018603 5.74 83472;287877;363465;58835;361042;680308;24552;84029;116686;24404;171142;25426;24296;290277;26760;286921;296925 ugdh;pycr1;pir;phgdh;pck2;mthfd2;me1;hao2;gsr;gpx1;ehhadh;cyp1b1;cyp1a1;cryl1;akr7a3;akr1b8;aass UGDH_10131;PYCR1_9631;PIR_9487;PHGDH_9470;PCK2_9440;MTHFD2_9261;ME1_9215;HAO2_8778;GSR_8755;GPX1_33050;EHHADH_8534;CYP1B1_32710;CYP1A1_8415;CRYL1_8388;AKR7A3_8015;AKR1B8_8013;AASS_7936 127.67196529411764 83.0393 5.81076 149.6141537064355 107.17907906624328 115.58616000627089 77.58169352941178 56.4566 1.48195 100.09641009573394 68.92506829358224 79.87420794240796 238.15126470588234 135.068 14.0792 289.0745652292652 194.88668132583035 214.22345088902387 13.5 198.106 59.3662;132.668;152.213;122.826;6.67763;622.58;13.1175;140.856;69.5519;8.00432;166.899;229.313;83.0393;32.8011;57.1167;267.583;5.81076 25.4417;90.3184;56.4566;67.6778;1.48195;414.266;6.20444;93.5219;41.1016;2.69961;105.26;185.32;63.0271;15.4462;33.0666;114.994;2.60489 135.068;239.858;371.778;246.456;37.9425;1250.29;28.4614;282.925;124.212;25.2254;384.658;299.27;119.986;74.622;102.949;310.791;14.0792 13 4 13 83472;287877;363465;58835;361042;680308;24552;116686;25426;24296;290277;26760;286921 UGDH_10131;PYCR1_9631;PIR_9487;PHGDH_9470;PCK2_9440;MTHFD2_9261;ME1_9215;GSR_8755;CYP1B1_32710;CYP1A1_8415;CRYL1_8388;AKR7A3_8015;AKR1B8_8013 142.21948692307691 83.0393 164.44757196638813 85.75403 56.4566 110.75175040309912 257.0526076923077 135.068 317.9840998818192 59.3662;132.668;152.213;122.826;6.67763;622.58;13.1175;69.5519;229.313;83.0393;32.8011;57.1167;267.583 25.4417;90.3184;56.4566;67.6778;1.48195;414.266;6.20444;41.1016;185.32;63.0271;15.4462;33.0666;114.994 135.068;239.858;371.778;246.456;37.9425;1250.29;28.4614;124.212;299.27;119.986;74.622;102.949;310.791 4 84029;24404;171142;296925 HAO2_8778;GPX1_33050;EHHADH_8534;AASS_7936 80.39251999999999 74.43016 85.52133051591751 51.02160000000001 48.110755 56.057327976022904 176.7219 154.0752 186.11856213030805 140.856;8.00432;166.899;5.81076 93.5219;2.69961;105.26;2.60489 282.925;25.2254;384.658;14.0792 0 Exp 4,3(0.18);Exp 5,1(0.06);Hill,7(0.42);Linear,2(0.12);Poly 2,4(0.24) 2.3247570408241485 43.56180739402771 1.5039241313934326 6.292444229125977 1.3437240153734327 2.120844841003418 56.54991121851188 198.79401936972337 29.998880571946337 125.16450648687717 100.73393920030972 375.568590211455 UP 0.7647058823529411 0.23529411764705882 0.0 GO:0048589 3 developmental growth 91 95 5 5 5 3 3 3 66 92 2386 0.74496 0.47958 0.74206 3.16 24404;25317;24890 gpx1;fgf1;esr1 GPX1_33050;FGF1_8633;ESR1_33192 231.56887333333336 12.5403 8.00432 383.3036010893612 267.81445784685224 396.14602323498684 148.02380666666667 3.74981 2.69961 250.7999420184503 171.71863969163215 259.22434112864863 513.8407333333333 51.2968 25.2254 823.831228103726 591.9170929445432 851.2425497033043 8.00432;674.162;12.5403 2.69961;437.622;3.74981 25.2254;1465.0;51.2968 1 2 1 25317 FGF1_8633 674.162 674.162 437.622 437.622 1465.0 1465.0 674.162 437.622 1465.0 2 24404;24890 GPX1_33050;ESR1_33192 10.272310000000001 10.272310000000001 3.20742221732655 3.22471 3.22471 0.7426035416021101 38.2611 38.2611 18.435263735026957 8.00432;12.5403 2.69961;3.74981 25.2254;51.2968 0 Hill,2(0.67);Linear,1(0.34) 1.6931385361972706 5.086913585662842 1.5704141855239868 1.7846373319625854 0.11161108349283966 1.7318620681762695 -202.17998371644615 665.3177303831128 -135.7830448460392 431.83065817937256 -418.41206203917875 1446.0935287058455 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0006268 10 DNA unwinding involved in DNA replication 5 5 2 2 2 2 2 2 67 3 2475 0.99982 0.0068619 0.0068619 40.0 29685;312538 mcm6;mcm2 MCM6_9210;MCM2_9206 2.82152 2.82152 1.87441 1.3394158070591826 2.495581895261845 1.257602245528927 0.72653 0.72653 0.496857 0.324806671510916 0.6474904139650873 0.30496698433905783 16.22585 16.22585 9.53 9.469361881615892 13.92154251870324 8.89095880702861 0.0 1.87441 0.0 1.87441 1.87441;3.76863 0.496857;0.956203 9.53;22.9217 2 0 2 29685;312538 MCM6_9210;MCM2_9206 2.82152 2.82152 1.3394158070591826 0.72653 0.72653 0.324806671510916 16.22585 16.22585 9.469361881615892 1.87441;3.76863 0.496857;0.956203 9.53;22.9217 0 0 Hill,2(1) 1.6681865432896064 3.349225163459778 1.5280487537384033 1.8211764097213745 0.2072725532988764 1.674612581729889 0.9651844000000005 4.677855599999999 0.2763709200000001 1.17668908 3.1019840000000016 29.349716 UP 1.0 0.0 0.0 GO:0006730 4 one-carbon metabolic process 9 10 2 2 2 2 2 2 67 8 2470 0.99801 0.028287 0.028287 20.0 680308;54232 mthfd2;car3 MTHFD2_9261;CAR3_8196 313.01466500000004 313.01466500000004 3.44933 437.79149519757055 281.5474063597659 435.5238415226675 208.19871500000002 208.19871500000002 2.13143 291.42314920840187 187.25201386375733 289.9136480360321 628.155565 628.155565 6.02113 879.8309555963226 564.9157155667908 875.2736448179327 0.0 3.44933 0.0 3.44933 622.58;3.44933 414.266;2.13143 1250.29;6.02113 1 1 1 680308 MTHFD2_9261 622.58 622.58 414.266 414.266 1250.29 1250.29 622.58 414.266 1250.29 1 54232 CAR3_8196 3.44933 3.44933 2.13143 2.13143 6.02113 6.02113 3.44933 2.13143 6.02113 0 Exp 4,1(0.5);Linear,1(0.5) 3.2135459793146195 8.286988615989685 1.5278362035751343 6.759152412414551 3.6990991658014525 4.1434943079948425 -293.7333915999999 919.7627216 -195.69316359999996 612.0905936 -591.2279275999997 1847.5390575999998 CONFLICT 0.5 0.5 0.0 GO:0045598 6 regulation of fat cell differentiation 37 42 4 4 3 4 3 3 66 39 2439 0.97455 0.10329 0.10329 7.14 24539;64194;310395 lpl;insig1;noct LPL_32544;INSIG1_8906;CCRN4L_8232 534.3498 665.276 37.6554 445.88864807765646 494.8791686236889 433.22974670363266 311.47703333333334 433.686 13.2791 259.6431737658499 295.41315514837555 259.6815737564799 1651.6416666666667 1425.48 101.065 1675.1471881325333 1417.2890793681247 1531.827557109349 1.5 782.697 900.118;37.6554;665.276 487.466;13.2791;433.686 3428.38;101.065;1425.48 2 1 2 64194;310395 INSIG1_8906;CCRN4L_8232 351.46569999999997 351.46569999999997 443.7947822723697 223.48255 223.48255 297.2725698476147 763.2725 763.2725 936.5028276051813 37.6554;665.276 13.2791;433.686 101.065;1425.48 1 24539 LPL_32544 900.118 900.118 487.466 487.466 3428.38 3428.38 900.118 487.466 3428.38 0 Exp 2,1(0.34);Exp 5,1(0.34);Linear,1(0.34) 1.805762636512924 5.427703499794006 1.7036563158035278 1.9665359258651733 0.13886285555804515 1.7575112581253052 29.77929524738289 1038.920304752617 17.663123050087336 605.2909436165794 -243.96582613443684 3547.2491594677704 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0045113 7 regulation of integrin biosynthetic process 2 2 1 1 1 1 1 1 68 1 2477 0.99928 0.053458 0.053458 50.0 94195 s100a9 S100A9_9775 963.318 963.318 963.318 963.318 802.143 802.143 802.143 802.143 1158.68 1158.68 1158.68 1158.68 0.0 963.318 0.0 963.318 963.318 802.143 1158.68 1 0 1 94195 S100A9_9775 963.318 963.318 802.143 802.143 1158.68 1158.68 963.318 802.143 1158.68 0 0 Poly 2,1(1) 1.7056305408477783 1.7056305408477783 1.7056305408477783 1.7056305408477783 0.0 1.7056305408477783 963.318 963.318 802.143 802.143 1158.68 1158.68 UP 1.0 0.0 0.0 GO:0070488 7 neutrophil aggregation 2 2 1 1 1 1 1 1 68 1 2477 0.99928 0.053458 0.053458 50.0 94195 s100a9 S100A9_9775 963.318 963.318 963.318 963.318 802.143 802.143 802.143 802.143 1158.68 1158.68 1158.68 1158.68 0.0 963.318 0.0 963.318 963.318 802.143 1158.68 1 0 1 94195 S100A9_9775 963.318 963.318 802.143 802.143 1158.68 1158.68 963.318 802.143 1158.68 0 0 Poly 2,1(1) 1.7056305408477783 1.7056305408477783 1.7056305408477783 1.7056305408477783 0.0 1.7056305408477783 963.318 963.318 802.143 802.143 1158.68 1158.68 UP 1.0 0.0 0.0 GO:0048869 3 cellular developmental process 541 573 36 36 32 18 15 15 54 558 1920 0.50753 0.60841 1.0 2.62 308843;360243;94195;363465;58835;361042;259241;29200;360504;24426;24404;25317;24890;24296;25748 tsku;top2a;s100a9;pir;phgdh;pck2;nr1d2;inhba;hba-a2;gstp1;gpx1;fgf1;esr1;cyp1a1;alas2 TSKU_10094;TOP2A_10059;S100A9_9775;PIR_9487;PHGDH_9470;PCK2_9440;NR1D2_9358;INHBA_33300;HBA2_32600;GSTP1_8762;GPX1_33050;FGF1_8633;ESR1_33192;CYP1A1_8415;ALAS2_8019 173.02807066666693 92.2997 4.48597E-12 273.04959819480746 134.78854856224237 230.37173247179035 119.30329133333363 56.4566 4.48597E-12 217.12132478469542 87.73194318156764 166.24312505116555 307.0742200000003 186.93 4.48599E-12 425.26561346814105 269.63866688981693 438.7799031304041 92.2997;4.48597E-12;963.318;152.213;122.826;6.67763;9.46041;91.8104;131.05;122.514;8.00432;674.162;12.5403;83.0393;125.506 49.0864;4.48597E-12;802.143;56.4566;67.6778;1.48195;2.2133;44.1594;88.5948;84.8469;2.69961;437.622;3.74981;63.0271;85.7907 185.899;4.48599E-12;1158.68;371.778;246.456;37.9425;49.4216;186.93;254.163;216.573;25.2254;1465.0;51.2968;119.986;236.762 10 5 10 308843;360243;94195;363465;58835;361042;259241;24426;25317;24296 TSKU_10094;TOP2A_10059;S100A9_9775;PIR_9487;PHGDH_9470;PCK2_9440;NR1D2_9358;GSTP1_8762;FGF1_8633;CYP1A1_8415 222.65100400000046 107.40684999999999 325.84161616945175 156.45550500000044 59.74185 260.6655521061042 385.17361000000045 201.236 505.95100287527686 92.2997;4.48597E-12;963.318;152.213;122.826;6.67763;9.46041;122.514;674.162;83.0393 49.0864;4.48597E-12;802.143;56.4566;67.6778;1.48195;2.2133;84.8469;437.622;63.0271 185.899;4.48599E-12;1158.68;371.778;246.456;37.9425;49.4216;216.573;1465.0;119.986 5 29200;360504;24404;24890;25748 INHBA_33300;HBA2_32600;GPX1_33050;ESR1_33192;ALAS2_8019 73.78220400000001 91.8104 59.91090929752344 44.998864000000005 44.1594 41.99998679947923 150.87544 186.93 106.1232663373494 91.8104;131.05;8.00432;12.5403;125.506 44.1594;88.5948;2.69961;3.74981;85.7907 186.93;254.163;25.2254;51.2968;236.762 0 Exp 4,2(0.14);Hill,7(0.47);Linear,1(0.07);Poly 2,5(0.34) 2.235234529283695 37.390013098716736 1.528982162475586 6.292444229125977 1.4598447310740748 1.7978414297103882 34.84590859104381 311.21023274229003 9.424740733645038 229.18184193302227 91.86012587956631 522.2883141204343 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0033273 5 response to vitamin 73 78 8 8 8 8 8 8 61 70 2408 0.99981 9.9319E-4 9.9319E-4 10.26 24614;59107;116682;24426;116686;24404;24296;24207 orm1;ltbp1;kynu;gstp1;gsr;gpx1;cyp1a1;apoc3 ORM1_9400;LTBP1_33264;KYNU_8979;GSTP1_8762;GSR_8755;GPX1_33050;CYP1A1_8415;APOC3_32553 227.28112875000002 91.71015 2.87451 305.77717958635685 113.0659531334214 209.74970593629604 142.00096 67.8751 1.13737 183.505598864171 73.02608055866457 128.3592293972233 535.02635125 142.834 8.23841 819.4383658295985 241.57177529650534 539.9315226979321 2.5 76.29560000000001 6.5 715.942 662.49;769.394;100.381;122.514;69.5519;8.00432;83.0393;2.87451 432.445;438.027;72.7231;84.8469;41.1016;2.69961;63.0271;1.13737 1413.32;2211.2;161.456;216.573;124.212;25.2254;119.986;8.23841 4 4 4 24614;24426;116686;24296 ORM1_9400;GSTP1_8762;GSR_8755;CYP1A1_8415 234.3988 102.77664999999999 286.27753589150745 155.35514999999998 73.937 185.5878415517299 468.52275 170.3925 631.439698572173 662.49;122.514;69.5519;83.0393 432.445;84.8469;41.1016;63.0271 1413.32;216.573;124.212;119.986 4 59107;116682;24404;24207 LTBP1_33264;KYNU_8979;GPX1_33050;APOC3_32553 220.1634575 54.192660000000004 368.8848114113606 128.64677 37.711355 208.93772419993743 601.5299524999999 93.3407 1075.3022113374886 769.394;100.381;8.00432;2.87451 438.027;72.7231;2.69961;1.13737 2211.2;161.456;25.2254;8.23841 0 Exp 2,1(0.13);Exp 4,2(0.25);Hill,1(0.13);Linear,1(0.13);Poly 2,3(0.38) 2.300598206217069 21.946377277374268 1.5140434503555298 6.292444229125977 1.9674276354143372 1.798611342906952 15.38835387674257 439.1739036232574 14.838067724297375 269.1638522757026 -32.81546548768131 1102.8681679876809 CONFLICT 0.5 0.5 0.0 GO:0045664 8 regulation of neuron differentiation 157 165 7 7 7 3 3 3 66 162 2316 0.3356 0.83615 0.62296 1.82 192247;94195;338475 sez6;s100a9;nrep SEZ6_9819;S100A9_9775;NREP_9364 388.3720666666666 191.159 10.6392 506.0325772521106 247.20258615562844 406.78493756439644 307.3298233333333 115.886 3.96047 432.15956650138344 185.49190506758057 345.0654885900838 545.4159000000001 448.068 29.4997 570.8498031030842 396.62724656304306 480.1232439570637 10.6392;963.318;191.159 3.96047;802.143;115.886 29.4997;1158.68;448.068 1 2 1 94195 S100A9_9775 963.318 963.318 802.143 802.143 1158.68 1158.68 963.318 802.143 1158.68 2 192247;338475 SEZ6_9819;NREP_9364 100.89909999999999 100.89909999999999 127.64677471843935 59.923235 59.923235 79.14330125089836 238.78385 238.78385 295.97248331972514 10.6392;191.159 3.96047;115.886 29.4997;448.068 0 Hill,1(0.34);Poly 2,2(0.67) 2.44658991200066 7.7443907260894775 1.7056305408477783 3.747737169265747 1.051578175581833 2.291023015975952 -184.25770093597657 961.0018342693099 -181.7047630894603 796.3644097561269 -100.56146347728475 1191.3932634772846 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0043508 10 negative regulation of JUN kinase activity 1 1 1 1 1 1 1 1 68 0 2478 1.0 0.027091 0.027091 100.0 24426 gstp1 GSTP1_8762 122.514 122.514 122.514 122.51399999999998 84.8469 84.8469 84.8469 84.8469 216.573 216.573 216.573 216.573 0.0 122.514 0.0 122.514 122.514 84.8469 216.573 1 0 1 24426 GSTP1_8762 122.514 122.514 84.8469 84.8469 216.573 216.573 122.514 84.8469 216.573 0 0 Poly 2,1(1) 5.5128583908081055 5.5128583908081055 5.5128583908081055 5.5128583908081055 0.0 5.5128583908081055 122.514 122.514 84.8469 84.8469 216.573 216.573 UP 1.0 0.0 0.0 GO:0031346 7 positive regulation of cell projection organization 92 99 3 3 3 3 3 3 66 96 2382 0.72061 0.5075 0.74918 3.03 192247;94195;170496 sez6;s100a9;lcn2 SEZ6_9819;S100A9_9775;LCN2_32481 648.8610666666667 963.318 10.6392 552.7359433170719 566.8901499105546 579.8588299047914 452.67815666666667 551.931 3.96047 408.24279905665657 364.99971891174715 391.20158728781826 1757.5832333333335 1158.68 29.4997 2092.8240720754247 1875.0857266845558 2293.4028304748076 10.6392;963.318;972.626 3.96047;802.143;551.931 29.4997;1158.68;4084.57 2 1 2 94195;170496 S100A9_9775;LCN2_32481 967.972 967.972 6.581749919279151 677.037 677.037 176.92660193424837 2621.625 2621.625 2068.916660005908 963.318;972.626 802.143;551.931 1158.68;4084.57 1 192247 SEZ6_9819 10.6392 10.6392 3.96047 3.96047 29.4997 29.4997 10.6392 3.96047 29.4997 0 Hill,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 2.281154100015622 7.310358643531799 1.7056305408477783 3.747737169265747 1.1378364541707422 1.856990933418274 23.381465163476037 1274.3406681698575 -9.292059596303716 914.648372929637 -610.6701477700467 4125.836614436714 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0090087 6 regulation of peptide transport 199 214 9 9 8 6 5 5 64 209 2269 0.47123 0.70167 1.0 2.34 94195;361042;24614;24539;64194 s100a9;pck2;orm1;lpl;insig1 S100A9_9775;PCK2_9440;ORM1_9400;LPL_32544;INSIG1_8906 514.051806 662.49 6.67763 462.9533472122943 291.1480599809425 441.78571129323444 347.36301000000003 432.445 1.48195 340.93195755213094 183.33725638860017 297.1312600675498 1227.8775 1158.68 37.9425 1375.4126818613386 806.7999109927237 1370.803957285034 963.318;6.67763;662.49;900.118;37.6554 802.143;1.48195;432.445;487.466;13.2791 1158.68;37.9425;1413.32;3428.38;101.065 4 1 4 94195;361042;24614;64194 S100A9_9775;PCK2_9440;ORM1_9400;INSIG1_8906 417.5352575 350.0727 472.9321036869216 312.3372625 222.86205 383.14589865247456 677.7518749999999 629.8725000000001 710.463725573466 963.318;6.67763;662.49;37.6554 802.143;1.48195;432.445;13.2791 1158.68;37.9425;1413.32;101.065 1 24539 LPL_32544 900.118 900.118 487.466 487.466 3428.38 3428.38 900.118 487.466 3428.38 0 Exp 2,1(0.2);Exp 5,1(0.2);Hill,1(0.2);Linear,1(0.2);Poly 2,1(0.2) 1.6837296606652963 8.453587889671326 1.528982162475586 1.9665359258651733 0.17519228948976975 1.7036563158035278 108.25530532712088 919.8483066728793 48.5229731468541 646.2030468531459 22.27512852715995 2433.4798714728404 UP 0.8 0.2 0.0 GO:0031330 7 negative regulation of cellular catabolic process 57 58 2 2 2 2 2 2 67 56 2422 0.79368 0.47037 0.67 3.45 310395;24207 noct;apoc3 CCRN4L_8232;APOC3_32553 334.07525499999997 334.07525499999997 2.87451 468.388585447073 262.7212313215317 457.3894113191682 217.41168499999998 217.41168499999998 1.13737 305.8580694659509 170.81745830659537 298.6756011714476 716.859205 716.859205 8.23841 1002.1411388686047 564.1936517100006 978.6078478584672 665.276;2.87451 433.686;1.13737 1425.48;8.23841 1 1 1 310395 CCRN4L_8232 665.276 665.276 433.686 433.686 1425.48 1425.48 665.276 433.686 1425.48 1 24207 APOC3_32553 2.87451 2.87451 1.13737 1.13737 8.23841 8.23841 2.87451 1.13737 8.23841 0 Exp 4,1(0.5);Linear,1(0.5) 1.6363511946391172 3.281054973602295 1.5235437154769897 1.7575112581253052 0.16544003598417661 1.6405274868011475 -315.07820519999996 983.2287151999999 -206.48597239999992 641.3093423999999 -672.0375532 2105.7559632 CONFLICT 0.5 0.5 0.0 GO:0019752 6 carboxylic acid metabolic process 287 320 32 32 28 26 22 22 47 298 2180 1.0 1.6554E-5 1.6554E-5 6.88 83472;287877;293820;58835;361042;680308;24552;24539;116682;84029;24426;24404;29739;25283;25315;171142;25426;24296;290277;81508;25612;296925 ugdh;pycr1;psat1;phgdh;pck2;mthfd2;me1;lpl;kynu;hao2;gstp1;gpx1;gclm;gclc;ephx1;ehhadh;cyp1b1;cyp1a1;cryl1;bhmt;asns;aass UGDH_10131;PYCR1_9631;PSAT1_9583;PHGDH_9470;PCK2_9440;MTHFD2_9261;ME1_9215;LPL_32544;KYNU_8979;HAO2_8778;GSTP1_8762;GPX1_33050;GCLM_8700;GCLC_8699;EPHX1_8567;EHHADH_8534;CYP1B1_32710;CYP1A1_8415;CRYL1_8388;BHMT_8143;ASNS_8091;AASS_7936 143.15850863636362 91.71015 5.5396 215.56826834866598 118.92736915972338 174.1637119612328 86.8908 65.35245 1.48195 127.58975554837774 74.33549083043265 104.32617578253846 360.9052863636364 148.262 14.0792 734.9377052458731 278.4829753027988 591.7178576105681 15.0 140.856 59.3662;132.668;27.1579;122.826;6.67763;622.58;13.1175;900.118;100.381;140.856;122.514;8.00432;190.233;145.958;27.5708;166.899;229.313;83.0393;32.8011;5.5396;6.05608;5.81076 25.4417;90.3184;10.0144;67.6778;1.48195;414.266;6.20444;487.466;72.7231;93.5219;84.8469;2.69961;69.2223;96.7058;12.6303;105.26;185.32;63.0271;15.4462;1.97501;2.7438;2.60489 135.068;239.858;103.876;246.456;37.9425;1250.29;28.4614;3428.38;161.456;282.925;216.573;25.2254;496.452;280.185;61.9858;384.658;299.27;119.986;74.622;37.8319;14.3351;14.0792 15 7 15 83472;287877;293820;58835;361042;680308;24552;24426;29739;25283;25315;25426;24296;290277;25612 UGDH_10131;PYCR1_9631;PSAT1_9583;PHGDH_9470;PCK2_9440;MTHFD2_9261;ME1_9215;GSTP1_8762;GCLM_8700;GCLC_8699;EPHX1_8567;CYP1B1_32710;CYP1A1_8415;CRYL1_8388;ASNS_8091 121.45856733333333 83.0393 155.2287277455054 76.35647266666666 63.0271 106.1508035396728 240.35738666666663 135.068 308.4121910515927 59.3662;132.668;27.1579;122.826;6.67763;622.58;13.1175;122.514;190.233;145.958;27.5708;229.313;83.0393;32.8011;6.05608 25.4417;90.3184;10.0144;67.6778;1.48195;414.266;6.20444;84.8469;69.2223;96.7058;12.6303;185.32;63.0271;15.4462;2.7438 135.068;239.858;103.876;246.456;37.9425;1250.29;28.4614;216.573;496.452;280.185;61.9858;299.27;119.986;74.622;14.3351 7 24539;116682;84029;24404;171142;81508;296925 LPL_32544;KYNU_8979;HAO2_8778;GPX1_33050;EHHADH_8534;BHMT_8143;AASS_7936 189.65838285714287 100.381 320.4998320188572 109.46435857142858 72.7231 172.6647122979506 619.2222142857144 161.456 1246.7343033973523 900.118;100.381;140.856;8.00432;166.899;5.5396;5.81076 487.466;72.7231;93.5219;2.69961;105.26;1.97501;2.60489 3428.38;161.456;282.925;25.2254;384.658;37.8319;14.0792 0 Exp 2,1(0.05);Exp 4,3(0.14);Hill,9(0.41);Linear,2(0.1);Poly 2,7(0.32) 2.2761712956881626 54.83395528793335 1.5039241313934326 6.292444229125977 1.2691176213756528 1.933137059211731 53.078262534834536 233.2387547378928 33.57443452619936 140.20716547380064 53.79436570270593 668.0162070245668 UP 0.6818181818181818 0.3181818181818182 0.0 GO:0043085 5 positive regulation of catalytic activity 340 363 14 14 11 7 4 4 65 359 2119 0.022763 0.99274 0.052156 1.1 94195;29739;25317;24890 s100a9;gclm;fgf1;esr1 S100A9_9775;GCLM_8700;FGF1_8633;ESR1_33192 460.063325 432.1975 12.5403 436.7259906550359 379.4815220102021 382.6998595111332 328.1842775 253.42215000000002 3.74981 369.2029772507882 246.35643702059323 293.1746919795604 792.8572 827.566 51.2968 638.5844068528661 775.2959737389004 699.3082724057017 963.318;190.233;674.162;12.5403 802.143;69.2223;437.622;3.74981 1158.68;496.452;1465.0;51.2968 3 1 3 94195;29739;25317 S100A9_9775;GCLM_8700;FGF1_8633 609.2376666666667 674.162 390.610395535415 436.3291 437.622 366.46206053960077 1040.044 1158.68 495.05270673737374 963.318;190.233;674.162 802.143;69.2223;437.622 1158.68;496.452;1465.0 1 24890 ESR1_33192 12.5403 12.5403 3.74981 3.74981 51.2968 51.2968 12.5403 3.74981 51.2968 0 Hill,2(0.5);Linear,1(0.25);Poly 2,1(0.25) 1.7250146374702255 6.916699051856995 1.5704141855239868 1.90879225730896 0.13907901498573874 1.718746304512024 32.07185415806481 888.0547958419352 -33.63464020577243 690.0031952057725 167.04448128419142 1418.6699187158088 UP 0.75 0.25 0.0 GO:0009987 2 cellular process 2111 2325 128 126 108 80 64 64 5 2261 217 0.73269 0.43382 0.82961 2.75 83472;308843;360243;266730;171497;192247;94195;291317;293656;287877;293820;363465;58835;361042;24614;338475;259241;680308;24567;313108;24552;29685;312538;59107;24539;287598;287167;170496;116682;288001;293502;64194;29200;25663;360504;84029;24426;300850;116686;24404;29739;25283;499709;84586;25317;24890;25315;171142;298452;25426;24296;290277;310395;54232;117517;81508;25612;24207;301111;25748;26760;360887;114628;296925 ugdh;tsku;top2a;slc17a3;sgk2;sez6;s100a9;rpp38;rgd1307603;pycr1;psat1;pir;phgdh;pck2;orm1;nrep;nr1d2;mthfd2;mt1;mms22l;me1;mcm6;mcm2;ltbp1;lpl;ska2;hba-a1;lcn2;kynu;kng1;kif22;insig1;inhba;il1r1;hba-a2;hao2;gstp1;gsta4;gsr;gpx1;gclm;gclc;gar1;fgl2;fgf1;esr1;ephx1;ehhadh;dph2;cyp1b1;cyp1a1;cryl1;noct;car3;c7;bhmt;asns;apoc3;ano10;alas2;akr7a3;coq8a;abcg5;aass UGDH_10131;TSKU_10094;TOP2A_10059;SLC17A3_9840;SGK2_32380;SEZ6_9819;S100A9_9775;RPP38_9741;RGD1307603_9684;PYCR1_9631;PSAT1_9583;PIR_9487;PHGDH_9470;PCK2_9440;ORM1_9400;NREP_9364;NR1D2_9358;MTHFD2_9261;MT1A_9255;MMS22L_33129;ME1_9215;MCM6_9210;MCM2_9206;LTBP1_33264;LPL_32544;LOC691962_32591;LOC287167_9118;LCN2_32481;KYNU_8979;KNG1L1_32433;KIF22_8963;INSIG1_8906;INHBA_33300;IL1R1_8893;HBA2_32600;HAO2_8778;GSTP1_8762;GSTA4_8757;GSR_8755;GPX1_33050;GCLM_8700;GCLC_8699;GAR1_8683;FGL2_32918;FGF1_8633;ESR1_33192;EPHX1_8567;EHHADH_8534;DPH2_8490;CYP1B1_32710;CYP1A1_8415;CRYL1_8388;CCRN4L_8232;CAR3_8196;C7_8179;BHMT_8143;ASNS_8091;APOC3_32553;ANO10_8049;ALAS2_8019;AKR7A3_8015;ADCK3_7987;ABCG5_7947;AASS_7936 288001(0.1788);499709(-0.07184) 223.3398855625001 96.88245 4.48597E-12 298.0448285353043 182.11155463358392 263.2545956614865 145.85491725000009 59.74185 4.48597E-12 207.0944135704003 118.88357216156174 182.47595516198794 490.8335079687501 186.4145 4.48599E-12 780.7595383033059 397.94096926503806 685.472930386506 59.3662;92.2997;4.48597E-12;93.3839;156.37;10.6392;963.318;916.962;32.0155;132.668;27.1579;152.213;122.826;6.67763;662.49;191.159;9.46041;622.58;818.334;4.13516;13.1175;1.87441;3.76863;769.394;900.118;2.47312;149.282;972.626;100.381;3.87556;0.961856;37.6554;91.8104;76.6218;131.05;140.856;122.514;339.498;69.5519;8.00432;190.233;145.958;765.364;146.406;674.162;12.5403;27.5708;166.899;734.134;229.313;83.0393;32.8011;665.276;3.44933;103.858;5.5396;6.05608;2.87451;9.9207;125.506;57.1167;525.072;565.363;5.81076 25.4417;49.0864;4.48597E-12;68.9252;100.616;3.96047;802.143;769.912;12.3892;90.3184;10.0144;56.4566;67.6778;1.48195;432.445;115.886;2.2133;414.266;540.216;1.24709;6.20444;0.496857;0.956203;438.027;487.466;0.810493;97.0024;551.931;72.7231;1.25511;0.281971;13.2791;44.1594;27.5215;88.5948;93.5219;84.8469;260.156;41.1016;2.69961;69.2223;96.7058;587.034;95.6156;437.622;3.74981;12.6303;105.26;463.289;185.32;63.0271;15.4462;433.686;2.13143;32.7314;1.97501;2.7438;1.13737;2.9165;85.7907;33.0666;336.426;386.851;2.60489 135.068;185.899;4.48599E-12;143.418;343.205;29.4997;1158.68;1051.72;78.5761;239.858;103.876;371.778;246.456;37.9425;1413.32;448.068;49.4216;1250.29;988.495;20.8956;28.4614;9.53;22.9217;2211.2;3428.38;10.3838;334.152;4084.57;161.456;13.8374;4.47267;101.065;186.93;185.143;254.163;282.925;216.573;486.944;124.212;25.2254;496.452;280.185;1362.21;325.091;1465.0;51.2968;61.9858;384.658;1764.85;299.27;119.986;74.622;1425.48;6.02113;293.781;37.8319;14.3351;8.23841;33.1883;236.762;102.949;1038.12;1047.94;14.0792 39 25 39 83472;308843;360243;266730;171497;94195;287877;293820;363465;58835;361042;24614;259241;680308;313108;24552;29685;312538;287598;170496;288001;293502;64194;25663;24426;300850;116686;29739;25283;499709;25317;25315;25426;24296;290277;310395;25612;301111;26760 UGDH_10131;TSKU_10094;TOP2A_10059;SLC17A3_9840;SGK2_32380;S100A9_9775;PYCR1_9631;PSAT1_9583;PIR_9487;PHGDH_9470;PCK2_9440;ORM1_9400;NR1D2_9358;MTHFD2_9261;MMS22L_33129;ME1_9215;MCM6_9210;MCM2_9206;LOC691962_32591;LCN2_32481;KNG1L1_32433;KIF22_8963;INSIG1_8906;IL1R1_8893;GSTP1_8762;GSTA4_8757;GSR_8755;GCLM_8700;GCLC_8699;GAR1_8683;FGF1_8633;EPHX1_8567;CYP1B1_32710;CYP1A1_8415;CRYL1_8388;CCRN4L_8232;ASNS_8091;ANO10_8049;AKR7A3_8015 195.80242964102578 76.6218 283.5358548645832 129.5024260000001 41.1016 201.46208085358964 428.8175607692309 135.068 755.8191326429929 59.3662;92.2997;4.48597E-12;93.3839;156.37;963.318;132.668;27.1579;152.213;122.826;6.67763;662.49;9.46041;622.58;4.13516;13.1175;1.87441;3.76863;2.47312;972.626;3.87556;0.961856;37.6554;76.6218;122.514;339.498;69.5519;190.233;145.958;765.364;674.162;27.5708;229.313;83.0393;32.8011;665.276;6.05608;9.9207;57.1167 25.4417;49.0864;4.48597E-12;68.9252;100.616;802.143;90.3184;10.0144;56.4566;67.6778;1.48195;432.445;2.2133;414.266;1.24709;6.20444;0.496857;0.956203;0.810493;551.931;1.25511;0.281971;13.2791;27.5215;84.8469;260.156;41.1016;69.2223;96.7058;587.034;437.622;12.6303;185.32;63.0271;15.4462;433.686;2.7438;2.9165;33.0666 135.068;185.899;4.48599E-12;143.418;343.205;1158.68;239.858;103.876;371.778;246.456;37.9425;1413.32;49.4216;1250.29;20.8956;28.4614;9.53;22.9217;10.3838;4084.57;13.8374;4.47267;101.065;185.143;216.573;486.944;124.212;496.452;280.185;1362.21;1465.0;61.9858;299.27;119.986;74.622;1425.48;14.3351;33.1883;102.949 25 192247;291317;293656;338475;24567;59107;24539;287167;116682;29200;360504;84029;24404;84586;24890;171142;298452;54232;117517;81508;24207;25748;360887;114628;296925 SEZ6_9819;RPP38_9741;RGD1307603_9684;NREP_9364;MT1A_9255;LTBP1_33264;LPL_32544;LOC287167_9118;KYNU_8979;INHBA_33300;HBA2_32600;HAO2_8778;GPX1_33050;FGL2_32918;ESR1_33192;EHHADH_8534;DPH2_8490;CAR3_8196;C7_8179;BHMT_8143;APOC3_32553;ALAS2_8019;ADCK3_7987;ABCG5_7947;AASS_7936 266.2983168 131.05 320.527394347848 171.36480360000002 88.5948 217.269761578852 587.5783856 282.925 824.4170674520117 10.6392;916.962;32.0155;191.159;818.334;769.394;900.118;149.282;100.381;91.8104;131.05;140.856;8.00432;146.406;12.5403;166.899;734.134;3.44933;103.858;5.5396;2.87451;125.506;525.072;565.363;5.81076 3.96047;769.912;12.3892;115.886;540.216;438.027;487.466;97.0024;72.7231;44.1594;88.5948;93.5219;2.69961;95.6156;3.74981;105.26;463.289;2.13143;32.7314;1.97501;1.13737;85.7907;336.426;386.851;2.60489 29.4997;1051.72;78.5761;448.068;988.495;2211.2;3428.38;334.152;161.456;186.93;254.163;282.925;25.2254;325.091;51.2968;384.658;1764.85;6.02113;293.781;37.8319;8.23841;236.762;1038.12;1047.94;14.0792 0 Exp 2,4(0.07);Exp 4,12(0.19);Exp 5,1(0.02);Hill,21(0.33);Linear,9(0.15);Poly 2,17(0.27) 2.0426145163953486 141.39831244945526 1.503517508506775 6.759152412414551 1.113486241561828 1.7741119861602783 150.31890257135046 296.3608685536496 95.116785925252 196.5930485747481 299.5474210844402 682.1195948530602 UP 0.609375 0.390625 0.0 GO:0031110 7 regulation of microtubule polymerization or depolymerization 24 26 5 5 5 1 1 1 68 25 2453 0.84472 0.5121 0.5121 3.85 287598 ska2 LOC691962_32591 2.47312 2.47312 2.47312 2.47312 0.810493 0.810493 0.810493 0.810493 10.3838 10.3838 10.3838 10.3838 2.47312 0.810493 10.3838 1 0 1 287598 LOC691962_32591 2.47312 2.47312 0.810493 0.810493 10.3838 10.3838 2.47312 0.810493 10.3838 0 0 Exp 4,1(1) 1.503517508506775 1.503517508506775 1.503517508506775 1.503517508506775 0.0 1.503517508506775 2.47312 2.47312 0.810493 0.810493 10.3838 10.3838 UP 1.0 0.0 0.0 GO:0042537 5 benzene-containing compound metabolic process 17 24 5 5 4 4 3 3 66 21 2457 0.99652 0.025632 0.025632 12.5 116682;84029;25426 kynu;hao2;cyp1b1 KYNU_8979;HAO2_8778;CYP1B1_32710 156.85 140.856 100.381 65.93725186114449 178.2203147224457 69.13524444156968 117.18833333333333 93.5219 72.7231 59.91319155614507 137.48814002145346 63.3590030773138 247.88366666666664 282.925 161.456 75.29339898246948 261.92618337355856 70.50044473650209 0.5 120.6185 1.5 185.0845 100.381;140.856;229.313 72.7231;93.5219;185.32 161.456;282.925;299.27 1 2 1 25426 CYP1B1_32710 229.313 229.313 185.32 185.32 299.27 299.27 229.313 185.32 299.27 2 116682;84029 KYNU_8979;HAO2_8778 120.6185 120.6185 28.62014696852544 83.1225 83.1225 14.706972520542783 222.1905 222.1905 85.89155360394888 100.381;140.856 72.7231;93.5219 161.456;282.925 0 Linear,1(0.34);Poly 2,2(0.67) 2.3645291365656043 7.262724876403809 1.957481861114502 3.1843981742858887 0.6662277883052349 2.120844841003418 82.2349753811544 231.46502461884558 49.3901746783514 184.98649198831527 162.6811648920346 333.0861684412987 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0001819 6 positive regulation of cytokine production 132 142 7 7 6 5 4 4 65 138 2340 0.66024 0.54326 0.79238 2.82 24614;24539;25663;25426 orm1;lpl;il1r1;cyp1b1 ORM1_9400;LPL_32544;IL1R1_8893;CYP1B1_32710 467.13570000000004 445.9015 76.6218 380.656326787598 360.8924301363194 343.26990188963094 283.188125 308.8825 27.5215 215.21358226901594 229.96843950827653 188.20063972081462 1331.52825 856.295 185.143 1503.688064721398 950.3448420155794 1391.5652316029157 662.49;900.118;76.6218;229.313 432.445;487.466;27.5215;185.32 1413.32;3428.38;185.143;299.27 3 1 3 24614;25663;25426 ORM1_9400;IL1R1_8893;CYP1B1_32710 322.80826666666667 229.313 303.91842755847057 215.0955 185.32 204.09726973492323 632.5776666666667 299.27 678.546377432179 662.49;76.6218;229.313 432.445;27.5215;185.32 1413.32;185.143;299.27 1 24539 LPL_32544 900.118 900.118 487.466 487.466 3428.38 3428.38 900.118 487.466 3428.38 0 Exp 2,1(0.25);Hill,1(0.25);Linear,2(0.5) 1.942114715733676 8.130003690719604 1.5487829446792603 3.1843981742858887 0.7711759747325717 1.6984112858772278 94.0924997481539 840.1789002518462 72.27881437636438 494.09743562363565 -142.08605342697 2805.14255342697 UP 0.75 0.25 0.0 GO:0015747 6 urate transport 2 2 1 1 1 1 1 1 68 1 2477 0.99928 0.053458 0.053458 50.0 266730 slc17a3 SLC17A3_9840 93.3839 93.3839 93.3839 93.38390000000001 68.9252 68.9252 68.9252 68.9252 143.418 143.418 143.418 143.418 0.0 93.3839 0.0 93.3839 93.3839 68.9252 143.418 1 0 1 266730 SLC17A3_9840 93.3839 93.3839 68.9252 68.9252 143.418 143.418 93.3839 68.9252 143.418 0 0 Poly 2,1(1) 1.504341721534729 1.504341721534729 1.504341721534729 1.504341721534729 0.0 1.504341721534729 93.3839 93.3839 68.9252 68.9252 143.418 143.418 UP 1.0 0.0 0.0 GO:0006725 4 cellular aromatic compound metabolic process 429 482 32 32 29 22 19 19 50 463 2015 0.97346 0.049499 0.084499 3.94 83472;360243;266730;291317;680308;313108;29685;312538;116682;293502;84029;499709;24890;25315;25426;24296;310395;25748;296925 ugdh;top2a;slc17a3;rpp38;mthfd2;mms22l;mcm6;mcm2;kynu;kif22;hao2;gar1;esr1;ephx1;cyp1b1;cyp1a1;noct;alas2;aass UGDH_10131;TOP2A_10059;SLC17A3_9840;RPP38_9741;MTHFD2_9261;MMS22L_33129;MCM6_9210;MCM2_9206;KYNU_8979;KIF22_8963;HAO2_8778;GAR1_8683;ESR1_33192;EPHX1_8567;CYP1B1_32710;CYP1A1_8415;CCRN4L_8232;ALAS2_8019;AASS_7936 499709(-0.07184) 203.0889113684213 83.0393 4.48597E-12 297.3515190176028 158.2592293327016 265.84055750152976 148.50604321052657 63.0271 4.48597E-12 228.92726949676106 116.89353192585497 206.64990975759466 350.1982510526318 135.068 4.48599E-12 502.18957536829424 261.5477078926034 431.869595038453 59.3662;4.48597E-12;93.3839;916.962;622.58;4.13516;1.87441;3.76863;100.381;0.961856;140.856;765.364;12.5403;27.5708;229.313;83.0393;665.276;125.506;5.81076 25.4417;4.48597E-12;68.9252;769.912;414.266;1.24709;0.496857;0.956203;72.7231;0.281971;93.5219;587.034;3.74981;12.6303;185.32;63.0271;433.686;85.7907;2.60489 135.068;4.48599E-12;143.418;1051.72;1250.29;20.8956;9.53;22.9217;161.456;4.47267;282.925;1362.21;51.2968;61.9858;299.27;119.986;1425.48;236.762;14.0792 13 6 13 83472;360243;266730;680308;313108;29685;312538;293502;499709;25315;25426;24296;310395 UGDH_10131;TOP2A_10059;SLC17A3_9840;MTHFD2_9261;MMS22L_33129;MCM6_9210;MCM2_9206;KIF22_8963;GAR1_8683;EPHX1_8567;CYP1B1_32710;CYP1A1_8415;CCRN4L_8232 196.66409661538498 59.3662 286.6040911710503 137.94710930769267 25.4417 204.28793392824826 373.5021361538465 119.986 561.6175122138653 59.3662;4.48597E-12;93.3839;622.58;4.13516;1.87441;3.76863;0.961856;765.364;27.5708;229.313;83.0393;665.276 25.4417;4.48597E-12;68.9252;414.266;1.24709;0.496857;0.956203;0.281971;587.034;12.6303;185.32;63.0271;433.686 135.068;4.48599E-12;143.418;1250.29;20.8956;9.53;22.9217;4.47267;1362.21;61.9858;299.27;119.986;1425.48 6 291317;116682;84029;24890;25748;296925 RPP38_9741;KYNU_8979;HAO2_8778;ESR1_33192;ALAS2_8019;AASS_7936 217.0093433333333 112.9435 347.5976170427756 171.38373333333334 79.2569 295.95474965711617 299.7065 199.10899999999998 382.6673404706443 916.962;100.381;140.856;12.5403;125.506;5.81076 769.912;72.7231;93.5219;3.74981;85.7907;2.60489 1051.72;161.456;282.925;51.2968;236.762;14.0792 0 Exp 2,1(0.06);Exp 4,2(0.11);Hill,7(0.37);Linear,3(0.16);Poly 2,6(0.32) 1.9969965440449975 40.909411668777466 1.504341721534729 6.292444229125977 1.1130243104940385 1.7575112581253052 69.38336214063997 336.79446059620255 45.56778884274327 251.44429757830983 124.38627870111637 576.0102234041474 UP 0.6842105263157895 0.3157894736842105 0.0 GO:0031348 6 negative regulation of defense response 64 68 5 5 4 4 3 3 66 65 2413 0.88973 0.27939 0.43002 4.41 259241;24404;84586 nr1d2;gpx1;fgl2 NR1D2_9358;GPX1_33050;FGL2_32918 54.62357666666667 9.46041 8.00432 79.48924439335447 17.852985303012264 41.543895168626065 33.509503333333335 2.69961 2.2133 53.78600707183081 8.463769625550661 28.160130540364758 133.246 49.4216 25.2254 166.58253822763058 58.74925607810453 87.17230211057753 9.46041;8.00432;146.406 2.2133;2.69961;95.6156 49.4216;25.2254;325.091 1 2 1 259241 NR1D2_9358 9.46041 9.46041 2.2133 2.2133 49.4216 49.4216 9.46041 2.2133 49.4216 2 24404;84586 GPX1_33050;FGL2_32918 77.20516 77.20516 97.86476645561058 49.157605000000004 49.157605000000004 65.70152660966143 175.1582 175.1582 212.03699920457282 8.00432;146.406 2.69961;95.6156 25.2254;325.091 0 Hill,2(0.67);Poly 2,1(0.34) 1.861155833087079 5.620995283126831 1.6593536138534546 2.177004337310791 0.27006485283016457 1.7846373319625854 -35.326971163772306 144.57412449710566 -27.355093363317657 94.37410002998433 -55.25988764450676 321.7518876445068 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0060602 6 branch elongation of an epithelium 6 6 2 2 2 2 2 2 67 4 2474 0.99964 0.010113 0.010113 33.33 25317;24890 fgf1;esr1 FGF1_8633;ESR1_33192 343.35115 343.35115 12.5403 467.83719065017164 376.47621656986917 465.4858718424529 220.68590500000002 220.68590500000002 3.74981 306.7939677172581 242.4083563291582 305.2520415070189 758.1484 758.1484 51.2968 999.639119305122 828.9275364914981 994.6149991429629 0.0 12.5403 0.0 12.5403 674.162;12.5403 437.622;3.74981 1465.0;51.2968 1 1 1 25317 FGF1_8633 674.162 674.162 437.622 437.622 1465.0 1465.0 674.162 437.622 1465.0 1 24890 ESR1_33192 12.5403 12.5403 3.74981 3.74981 51.2968 51.2968 12.5403 3.74981 51.2968 0 Hill,1(0.5);Linear,1(0.5) 1.6491636544730555 3.3022762537002563 1.5704141855239868 1.7318620681762695 0.11416089263163907 1.6511381268501282 -305.038116 991.7404160000001 -204.50884119999998 645.8806512 -627.2807359999997 2143.577536 CONFLICT 0.5 0.5 0.0 GO:0032922 6 circadian regulation of gene expression 22 23 4 4 3 3 2 2 67 21 2457 0.97714 0.12717 0.12717 8.7 316351;310395 npas2;noct NPAS2_9350;CCRN4L_8232 359.1387 359.1387 53.0014 432.9435216082809 553.0700584591758 334.99455117201103 224.03425 224.03425 14.3825 296.4923482252535 356.8440993089327 229.41403707969164 820.315 820.315 215.15 855.832550473514 1203.673939083696 662.2093340472076 0.5 359.1387 53.0014;665.276 14.3825;433.686 215.15;1425.48 1 1 1 310395 CCRN4L_8232 665.276 665.276 433.686 433.686 1425.48 1425.48 665.276 433.686 1425.48 1 316351 NPAS2_9350 53.0014 53.0014 14.3825 14.3825 215.15 215.15 53.0014 14.3825 215.15 0 Hill,1(0.5);Linear,1(0.5) 2.1545576370307002 4.398813605308533 1.7575112581253052 2.6413023471832275 0.6249346722251008 2.1994068026542664 -240.89040799999998 959.1678079999999 -186.88317999999992 634.9516799999999 -365.8083999999998 2006.4383999999995 CONFLICT 0.5 0.5 0.0 GO:0032502 2 developmental process 992 1073 62 62 53 37 30 30 39 1043 1435 0.64017 0.45514 0.80637 2.8 83472;308843;360243;192247;94195;363465;58835;361042;24614;338475;259241;312538;59107;116682;64194;29200;360504;24426;116686;24404;29739;25283;25317;24890;25315;24309;25426;24296;25612;25748 ugdh;tsku;top2a;sez6;s100a9;pir;phgdh;pck2;orm1;nrep;nr1d2;mcm2;ltbp1;kynu;insig1;inhba;hba-a2;gstp1;gsr;gpx1;gclm;gclc;fgf1;esr1;ephx1;dbp;cyp1b1;cyp1a1;asns;alas2 UGDH_10131;TSKU_10094;TOP2A_10059;SEZ6_9819;S100A9_9775;PIR_9487;PHGDH_9470;PCK2_9440;ORM1_9400;NREP_9364;NR1D2_9358;MCM2_9206;LTBP1_33264;KYNU_8979;INSIG1_8906;INHBA_33300;HBA2_32600;GSTP1_8762;GSR_8755;GPX1_33050;GCLM_8700;GCLC_8699;FGF1_8633;ESR1_33192;EPHX1_8567;DBP_8439;CYP1B1_32710;CYP1A1_8415;ASNS_8091;ALAS2_8019 172.1664990000002 92.05505 4.48597E-12 249.5683666829861 129.9310919819095 195.3173093171403 110.6660547666668 52.7715 4.48597E-12 181.49296801821103 81.85908877447633 137.2196840385745 356.1859866666668 186.4145 4.48599E-12 518.5021088098183 272.23634937513475 408.0138662537671 59.3662;92.2997;4.48597E-12;10.6392;963.318;152.213;122.826;6.67763;662.49;191.159;9.46041;3.76863;769.394;100.381;37.6554;91.8104;131.05;122.514;69.5519;8.00432;190.233;145.958;674.162;12.5403;27.5708;66.0377;229.313;83.0393;6.05608;125.506 25.4417;49.0864;4.48597E-12;3.96047;802.143;56.4566;67.6778;1.48195;432.445;115.886;2.2133;0.956203;438.027;72.7231;13.2791;44.1594;88.5948;84.8469;41.1016;2.69961;69.2223;96.7058;437.622;3.74981;12.6303;19.9899;185.32;63.0271;2.7438;85.7907 135.068;185.899;4.48599E-12;29.4997;1158.68;371.778;246.456;37.9425;1413.32;448.068;49.4216;22.9217;2211.2;161.456;101.065;186.93;254.163;216.573;124.212;25.2254;496.452;280.185;1465.0;51.2968;61.9858;280.428;299.27;119.986;14.3351;236.762 21 9 21 83472;308843;360243;94195;363465;58835;361042;24614;259241;312538;64194;24426;116686;29739;25283;25317;25315;24309;25426;24296;25612 UGDH_10131;TSKU_10094;TOP2A_10059;S100A9_9775;PIR_9487;PHGDH_9470;PCK2_9440;ORM1_9400;NR1D2_9358;MCM2_9206;INSIG1_8906;GSTP1_8762;GSR_8755;GCLM_8700;GCLC_8699;FGF1_8633;EPHX1_8567;DBP_8439;CYP1B1_32710;CYP1A1_8415;ASNS_8091 177.357654761905 83.0393 260.2537766100661 117.35194061904782 49.0864 200.70842310299196 337.1894619047621 185.899 443.7869283911631 59.3662;92.2997;4.48597E-12;963.318;152.213;122.826;6.67763;662.49;9.46041;3.76863;37.6554;122.514;69.5519;190.233;145.958;674.162;27.5708;66.0377;229.313;83.0393;6.05608 25.4417;49.0864;4.48597E-12;802.143;56.4566;67.6778;1.48195;432.445;2.2133;0.956203;13.2791;84.8469;41.1016;69.2223;96.7058;437.622;12.6303;19.9899;185.32;63.0271;2.7438 135.068;185.899;4.48599E-12;1158.68;371.778;246.456;37.9425;1413.32;49.4216;22.9217;101.065;216.573;124.212;496.452;280.185;1465.0;61.9858;280.428;299.27;119.986;14.3351 9 192247;338475;59107;116682;29200;360504;24404;24890;25748 SEZ6_9819;NREP_9364;LTBP1_33264;KYNU_8979;INHBA_33300;HBA2_32600;GPX1_33050;ESR1_33192;ALAS2_8019 160.05380222222223 100.381 237.0969707075146 95.06565444444443 72.7231 135.2981563056914 400.5112111111111 186.93 692.1245512403538 10.6392;191.159;769.394;100.381;91.8104;131.05;8.00432;12.5403;125.506 3.96047;115.886;438.027;72.7231;44.1594;88.5948;2.69961;3.74981;85.7907 29.4997;448.068;2211.2;161.456;186.93;254.163;25.2254;51.2968;236.762 0 Exp 2,1(0.04);Exp 4,4(0.14);Exp 5,1(0.04);Hill,13(0.44);Linear,3(0.1);Poly 2,8(0.27) 2.1736085318970524 70.70948946475983 1.5140434503555298 6.292444229125977 1.155074624653625 1.9057000875473022 82.85960593963185 261.4733920603684 45.71963026007009 175.61247927326357 170.6423899420316 541.7295833913021 UP 0.7 0.3 0.0 GO:0045595 5 regulation of cell differentiation 433 456 24 24 20 14 10 10 59 446 2032 0.28502 0.8168 0.52683 2.19 192247;94195;338475;259241;24539;64194;29200;25663;84586;310395 sez6;s100a9;nrep;nr1d2;lpl;insig1;inhba;il1r1;fgl2;noct SEZ6_9819;S100A9_9775;NREP_9364;NR1D2_9358;LPL_32544;INSIG1_8906;INHBA_33300;IL1R1_8893;FGL2_32918;CCRN4L_8232 309.246421 119.10820000000001 9.46041 379.8171784182601 247.21842126614422 343.6919196715343 202.593037 69.8875 2.2133 275.7166351001326 152.7966577227354 231.39057940918602 733.7758299999999 256.0105 29.4997 1061.0921531665047 629.4433489711485 1003.9122831920475 10.6392;963.318;191.159;9.46041;900.118;37.6554;91.8104;76.6218;146.406;665.276 3.96047;802.143;115.886;2.2133;487.466;13.2791;44.1594;27.5215;95.6156;433.686 29.4997;1158.68;448.068;49.4216;3428.38;101.065;186.93;185.143;325.091;1425.48 5 5 5 94195;259241;64194;25663;310395 S100A9_9775;NR1D2_9358;INSIG1_8906;IL1R1_8893;CCRN4L_8232 350.466322 76.6218 436.9836495112631 255.76858000000001 27.5215 355.446118499298 583.9579200000001 185.143 655.0635217990176 963.318;9.46041;37.6554;76.6218;665.276 802.143;2.2133;13.2791;27.5215;433.686 1158.68;49.4216;101.065;185.143;1425.48 5 192247;338475;24539;29200;84586 SEZ6_9819;NREP_9364;LPL_32544;INHBA_33300;FGL2_32918 268.02652 146.406 359.70132021207826 149.41749399999998 95.6156 193.99278947949375 883.59374 325.091 1431.1151321320335 10.6392;191.159;900.118;91.8104;146.406 3.96047;115.886;487.466;44.1594;95.6156 29.4997;448.068;3428.38;186.93;325.091 0 Exp 2,1(0.1);Exp 5,1(0.1);Hill,4(0.4);Linear,1(0.1);Poly 2,3(0.3) 2.033513690509614 20.994109392166138 1.6593536138534546 3.747737169265747 0.6326238355402833 1.8620235919952393 73.83329486099086 544.6595471390092 31.702096080066553 373.48397791993347 76.10409977767335 1391.4475602223267 CONFLICT 0.5 0.5 0.0 GO:0071385 8 cellular response to glucocorticoid stimulus 47 51 8 8 6 7 5 5 64 46 2432 0.99781 0.01127 0.01127 9.8 361042;24614;24426;25315;25426 pck2;orm1;gstp1;ephx1;cyp1b1 PCK2_9440;ORM1_9400;GSTP1_8762;EPHX1_8567;CYP1B1_32710 209.71308600000003 122.514 6.67763 268.04569564807406 129.6585155017932 193.40186747079304 143.34483 84.8469 1.48195 177.46421898502385 93.2182307033007 136.10405511449292 405.81826 216.573 37.9425 573.5371373306509 225.25169402467932 381.12808037338726 1.5 75.0424 6.67763;662.49;122.514;27.5708;229.313 1.48195;432.445;84.8469;12.6303;185.32 37.9425;1413.32;216.573;61.9858;299.27 5 0 5 361042;24614;24426;25315;25426 PCK2_9440;ORM1_9400;GSTP1_8762;EPHX1_8567;CYP1B1_32710 209.71308600000003 122.514 268.04569564807406 143.34483 84.8469 177.46421898502385 405.81826 216.573 573.5371373306509 6.67763;662.49;122.514;27.5708;229.313 1.48195;432.445;84.8469;12.6303;185.32 37.9425;1413.32;216.573;61.9858;299.27 0 0 Hill,2(0.4);Linear,2(0.4);Poly 2,1(0.2) 2.641047043619173 14.865911364555359 1.528982162475586 5.5128583908081055 1.6296509889114268 3.0908896923065186 -25.239325445762745 444.6654974457628 -12.209416431973438 298.8990764319734 -96.90920646325134 908.5457264632512 UP 1.0 0.0 0.0 GO:0045596 6 negative regulation of cell differentiation 184 195 9 9 7 6 4 4 65 191 2287 0.38107 0.78755 0.81701 2.05 192247;64194;84586;310395 sez6;insig1;fgl2;noct SEZ6_9819;INSIG1_8906;FGL2_32918;CCRN4L_8232 214.99415 92.0307 10.6392 305.8692839547149 269.30819865981164 351.1557946452472 136.6352925 54.44735 3.96047 202.27134971991515 171.19261055918204 232.87063941811826 470.283925 213.078 29.4997 649.1260470182114 586.0035029692103 744.6916181543885 10.6392;37.6554;146.406;665.276 3.96047;13.2791;95.6156;433.686 29.4997;101.065;325.091;1425.48 2 2 2 64194;310395 INSIG1_8906;CCRN4L_8232 351.46569999999997 351.46569999999997 443.7947822723697 223.48255 223.48255 297.2725698476147 763.2725 763.2725 936.5028276051813 37.6554;665.276 13.2791;433.686 101.065;1425.48 2 192247;84586 SEZ6_9819;FGL2_32918 78.5226 78.5226 96.0016249399978 49.788035 49.788035 64.80996395353458 177.29535 177.29535 209.01461268974714 10.6392;146.406 3.96047;95.6156 29.4997;325.091 0 Exp 5,1(0.25);Hill,1(0.25);Linear,1(0.25);Poly 2,1(0.25) 2.1531635438861385 9.13113796710968 1.6593536138534546 3.747737169265747 0.9850004284706626 1.8620235919952393 -84.75774827562054 514.7460482756205 -61.59063022551686 334.86121522551684 -165.85960107784717 1106.427451077847 CONFLICT 0.5 0.5 0.0 GO:0014823 3 response to activity 61 66 6 6 4 6 4 4 65 62 2416 0.9686 0.10152 0.10152 6.06 116686;29739;25283;114628 gsr;gclm;gclc;abcg5 GSR_8755;GCLM_8700;GCLC_8699;ABCG5_7947 242.776475 168.09550000000002 69.5519 220.7588830692192 293.77639656126786 247.70539051803672 148.47017499999998 82.96405 41.1016 160.53369826547066 186.97948337503792 180.25153242274618 487.19725 388.3185 124.212 403.7864309436983 573.2611375113739 447.9854781556035 2.5 377.798 69.5519;190.233;145.958;565.363 41.1016;69.2223;96.7058;386.851 124.212;496.452;280.185;1047.94 3 1 3 116686;29739;25283 GSR_8755;GCLM_8700;GCLC_8699 135.24763333333334 145.958 61.0492910679832 69.0099 69.2223 27.80270849629583 300.28299999999996 280.185 186.93207751212742 69.5519;190.233;145.958 41.1016;69.2223;96.7058 124.212;496.452;280.185 1 114628 ABCG5_7947 565.363 565.363 386.851 386.851 1047.94 1047.94 565.363 386.851 1047.94 0 Exp 4,1(0.25);Hill,1(0.25);Linear,1(0.25);Poly 2,1(0.25) 1.8154634184957175 7.265312671661377 1.7603585720062256 1.90879225730896 0.06524028575351219 1.7980809211730957 26.432769592165215 459.1201804078348 -8.852849300161239 305.7931993001612 91.48654767517581 882.9079523248242 UP 0.75 0.25 0.0 GO:0042391 4 regulation of membrane potential 94 95 4 4 4 4 4 4 65 91 2387 0.88775 0.25504 0.32505 4.21 192247;287877;29739;25283 sez6;pycr1;gclm;gclc SEZ6_9819;PYCR1_9631;GCLM_8700;GCLC_8699 119.87455 139.313 10.6392 76.86935215639154 126.12301777986029 67.34535779068509 65.0517425 79.77035000000001 3.96047 42.38679221552263 71.50507549795536 38.20964956982928 261.498675 260.0215 29.4997 191.3496684833532 266.7328790637247 171.30444976307274 10.6392;132.668;190.233;145.958 3.96047;90.3184;69.2223;96.7058 29.4997;239.858;496.452;280.185 3 1 3 287877;29739;25283 PYCR1_9631;GCLM_8700;GCLC_8699 156.28633333333332 145.958 30.140307867262038 85.41550000000001 90.3184 14.382785348116608 338.83166666666665 280.185 137.98439709740123 132.668;190.233;145.958 90.3184;69.2223;96.7058 239.858;496.452;280.185 1 192247 SEZ6_9819 10.6392 10.6392 3.96047 3.96047 29.4997 29.4997 10.6392 3.96047 29.4997 0 Hill,2(0.5);Poly 2,2(0.5) 2.171184464533505 9.181535482406616 1.7603585720062256 3.747737169265747 0.970689851255944 1.8367198705673218 44.54258488673632 195.20651511326366 23.512686128787813 106.5907988712122 73.97599988631387 449.02135011368614 UP 0.75 0.25 0.0 GO:0006541 9 glutamine metabolic process 8 8 2 2 2 2 2 2 67 6 2472 0.99903 0.018227 0.018227 25.0 58835;25612 phgdh;asns PHGDH_9470;ASNS_8091 64.44104 64.44104 6.05608 82.56880227061065 78.20424397022333 80.24185654227632 35.2108 35.2108 2.7438 45.91527172956729 42.864311166253096 44.62129213342077 130.39555 130.39555 14.3351 164.1342624451245 157.75471315136477 159.50864707506923 0.0 6.05608 0.0 6.05608 122.826;6.05608 67.6778;2.7438 246.456;14.3351 2 0 2 58835;25612 PHGDH_9470;ASNS_8091 64.44104 64.44104 82.56880227061065 35.2108 35.2108 45.91527172956729 130.39555 130.39555 164.1342624451245 122.826;6.05608 67.6778;2.7438 246.456;14.3351 0 0 Exp 4,1(0.5);Hill,1(0.5) 2.520073303843366 5.330282807350159 1.7978414297103882 3.5324413776397705 1.2265473858266984 2.6651414036750793 -49.993481599999996 178.87556159999997 -28.42452000000001 98.84612000000001 -97.08293199999997 357.874032 UP 1.0 0.0 0.0 GO:0043433 8 negative regulation of DNA-binding transcription factor activity 32 34 5 5 2 5 2 2 67 32 2446 0.93739 0.23454 0.23454 5.88 24890;25426 esr1;cyp1b1 ESR1_33192;CYP1B1_32710 120.92665 120.92665 12.5403 153.2814461461171 144.29113462242285 149.67766516518796 94.534905 94.534905 3.74981 128.38951261032986 114.10514568134683 125.3709627771374 175.2834 175.2834 51.2968 175.34353127252794 202.01077857752836 171.22105135720594 0.5 120.92665 12.5403;229.313 3.74981;185.32 51.2968;299.27 1 1 1 25426 CYP1B1_32710 229.313 229.313 185.32 185.32 299.27 299.27 229.313 185.32 299.27 1 24890 ESR1_33192 12.5403 12.5403 3.74981 3.74981 51.2968 51.2968 12.5403 3.74981 51.2968 0 Hill,1(0.5);Linear,1(0.5) 2.34839059954163 4.916260242462158 1.7318620681762695 3.1843981742858887 1.0270981305484141 2.458130121231079 -91.51059599999999 333.36389599999995 -83.40388119999999 272.47369119999996 -67.73033599999997 418.29713599999997 CONFLICT 0.5 0.5 0.0 GO:0006959 4 humoral immune response 62 73 2 2 2 2 2 2 67 71 2407 0.68305 0.59541 1.0 2.74 94195;117517 s100a9;c7 S100A9_9775;C7_8179 533.588 533.588 103.858 607.7299941585902 236.74056619868492 439.4302537276509 417.4372 417.4372 32.7314 544.0561598835914 151.69143056690956 393.38972681567253 726.2305 726.2305 293.781 611.5759479414638 427.5044992002844 442.21114073812805 963.318;103.858 802.143;32.7314 1158.68;293.781 1 1 1 94195 S100A9_9775 963.318 963.318 802.143 802.143 1158.68 1158.68 963.318 802.143 1158.68 1 117517 C7_8179 103.858 103.858 32.7314 32.7314 293.781 293.781 103.858 32.7314 293.781 0 Hill,1(0.5);Poly 2,1(0.5) 1.8147304569627778 3.6364394426345825 1.7056305408477783 1.9308089017868042 0.15922514599645718 1.8182197213172913 -308.68280000000004 1375.8588 -336.586168 1171.460568 -121.37052000000006 1573.8315200000002 CONFLICT 0.5 0.5 0.0 GO:0006529 7 asparagine biosynthetic process 1 1 1 1 1 1 1 1 68 0 2478 1.0 0.027091 0.027091 100.0 25612 asns ASNS_8091 6.05608 6.05608 6.05608 6.056079999999999 2.7438 2.7438 2.7438 2.7438 14.3351 14.3351 14.3351 14.3351 0.0 6.05608 0.0 6.05608 6.05608 2.7438 14.3351 1 0 1 25612 ASNS_8091 6.05608 6.05608 2.7438 2.7438 14.3351 14.3351 6.05608 2.7438 14.3351 0 0 Hill,1(1) 3.5324413776397705 3.5324413776397705 3.5324413776397705 3.5324413776397705 0.0 3.5324413776397705 6.05608 6.05608 2.7438 2.7438 14.3351 14.3351 UP 1.0 0.0 0.0 GO:0070981 7 L-asparagine biosynthetic process 1 1 1 1 1 1 1 1 68 0 2478 1.0 0.027091 0.027091 100.0 25612 asns ASNS_8091 6.05608 6.05608 6.05608 6.056079999999999 2.7438 2.7438 2.7438 2.7438 14.3351 14.3351 14.3351 14.3351 0.0 6.05608 0.0 6.05608 6.05608 2.7438 14.3351 1 0 1 25612 ASNS_8091 6.05608 6.05608 2.7438 2.7438 14.3351 14.3351 6.05608 2.7438 14.3351 0 0 Hill,1(1) 3.5324413776397705 3.5324413776397705 3.5324413776397705 3.5324413776397705 0.0 3.5324413776397705 6.05608 6.05608 2.7438 2.7438 14.3351 14.3351 UP 1.0 0.0 0.0 GO:0070982 7 L-asparagine metabolic process 1 1 1 1 1 1 1 1 68 0 2478 1.0 0.027091 0.027091 100.0 25612 asns ASNS_8091 6.05608 6.05608 6.05608 6.056079999999999 2.7438 2.7438 2.7438 2.7438 14.3351 14.3351 14.3351 14.3351 0.0 6.05608 0.0 6.05608 6.05608 2.7438 14.3351 1 0 1 25612 ASNS_8091 6.05608 6.05608 2.7438 2.7438 14.3351 14.3351 6.05608 2.7438 14.3351 0 0 Hill,1(1) 3.5324413776397705 3.5324413776397705 3.5324413776397705 3.5324413776397705 0.0 3.5324413776397705 6.05608 6.05608 2.7438 2.7438 14.3351 14.3351 UP 1.0 0.0 0.0 GO:0009650 7 UV protection 2 3 1 1 1 1 1 1 68 2 2476 0.99787 0.07912 0.07912 33.33 24404 gpx1 GPX1_33050 8.00432 8.00432 8.00432 8.00432 2.69961 2.69961 2.69961 2.69961 25.2254 25.2254 25.2254 25.2254 0.0 8.00432 0.0 8.00432 8.00432 2.69961 25.2254 0 1 0 1 24404 GPX1_33050 8.00432 8.00432 2.69961 2.69961 25.2254 25.2254 8.00432 2.69961 25.2254 0 Hill,1(1) 1.7846373319625854 1.7846373319625854 1.7846373319625854 1.7846373319625854 0.0 1.7846373319625854 8.00432 8.00432 2.69961 2.69961 25.2254 25.2254 DOWN 0.0 1.0 0.0 GO:0060255 5 regulation of macromolecule metabolic process 1000 1070 56 56 47 34 26 26 43 1044 1434 0.27073 0.80521 0.53677 2.43 308843;360243;299270;94195;363465;58835;24614;259241;316351;59107;24539;170496;288001;64194;29200;25663;24426;24404;25283;25317;24890;298452;24309;25426;289185;310395 tsku;top2a;serpina6;s100a9;pir;phgdh;orm1;nr1d2;npas2;ltbp1;lpl;lcn2;kng1;insig1;inhba;il1r1;gstp1;gpx1;gclc;fgf1;esr1;dph2;dbp;cyp1b1;creg1;noct TSKU_10094;TOP2A_10059;SERPINA6_32325;S100A9_9775;PIR_9487;PHGDH_9470;ORM1_9400;NR1D2_9358;NPAS2_9350;LTBP1_33264;LPL_32544;LCN2_32481;KNG1L1_32433;INSIG1_8906;INHBA_33300;IL1R1_8893;GSTP1_8762;GPX1_33050;GCLC_8699;FGF1_8633;ESR1_33192;DPH2_8490;DBP_8439;CYP1B1_32710;CREG1_8380;CCRN4L_8232 288001(0.1788) 295.7346073076925 110.09514999999999 4.48597E-12 349.07035927205055 253.70059029888316 320.9724037364356 183.10995192307706 52.7715 4.48597E-12 232.64041608072722 156.43147571992867 206.65251563661937 770.9827769230772 263.3205 4.48599E-12 1081.7408248259323 658.6158208405936 998.4648614011769 92.2997;4.48597E-12;25.7745;963.318;152.213;122.826;662.49;9.46041;53.0014;769.394;900.118;972.626;3.87556;37.6554;91.8104;76.6218;122.514;8.00432;145.958;674.162;12.5403;734.134;66.0377;229.313;97.6763;665.276 49.0864;4.48597E-12;8.17372;802.143;56.4566;67.6778;432.445;2.2133;14.3825;438.027;487.466;551.931;1.25511;13.2791;44.1594;27.5215;84.8469;2.69961;96.7058;437.622;3.74981;463.289;19.9899;185.32;36.7323;433.686 185.899;4.48599E-12;103.274;1158.68;371.778;246.456;1413.32;49.4216;215.15;2211.2;3428.38;4084.57;13.8374;101.065;186.93;185.143;216.573;25.2254;280.185;1465.0;51.2968;1764.85;280.428;299.27;282.14;1425.48 18 8 18 308843;360243;94195;363465;58835;24614;259241;170496;288001;64194;25663;24426;25283;25317;24309;25426;289185;310395 TSKU_10094;TOP2A_10059;S100A9_9775;PIR_9487;PHGDH_9470;ORM1_9400;NR1D2_9358;LCN2_32481;KNG1L1_32433;INSIG1_8906;IL1R1_8893;GSTP1_8762;GCLC_8699;FGF1_8633;DBP_8439;CYP1B1_32710;CREG1_8380;CCRN4L_8232 283.0179372222225 122.66999999999999 336.51718141721346 183.27287277777805 62.0672 239.34053411036837 669.9581111111114 280.3065 993.4079842830434 92.2997;4.48597E-12;963.318;152.213;122.826;662.49;9.46041;972.626;3.87556;37.6554;76.6218;122.514;145.958;674.162;66.0377;229.313;97.6763;665.276 49.0864;4.48597E-12;802.143;56.4566;67.6778;432.445;2.2133;551.931;1.25511;13.2791;27.5215;84.8469;96.7058;437.622;19.9899;185.32;36.7323;433.686 185.899;4.48599E-12;1158.68;371.778;246.456;1413.32;49.4216;4084.57;13.8374;101.065;185.143;216.573;280.185;1465.0;280.428;299.27;282.14;1425.48 8 299270;316351;59107;24539;29200;24404;24890;298452 SERPINA6_32325;NPAS2_9350;LTBP1_33264;LPL_32544;INHBA_33300;GPX1_33050;ESR1_33192;DPH2_8490 324.34711500000003 72.4059 398.5057472445458 182.74338 29.27095 232.75105508978027 998.288275 201.04000000000002 1302.7673893815204 25.7745;53.0014;769.394;900.118;91.8104;8.00432;12.5403;734.134 8.17372;14.3825;438.027;487.466;44.1594;2.69961;3.74981;463.289 103.274;215.15;2211.2;3428.38;186.93;25.2254;51.2968;1764.85 0 Exp 2,2(0.08);Exp 4,5(0.2);Exp 5,1(0.04);Hill,9(0.35);Linear,6(0.24);Poly 2,3(0.12) 1.9850576013677819 54.269266963005066 1.5140434503555298 5.5128583908081055 0.8389397913712616 1.7724979519844055 161.5562809942979 429.91293362108706 93.68585493684222 272.534048909312 355.17499054241273 1186.7905633037417 UP 0.6923076923076923 0.3076923076923077 0.0 GO:0060548 6 negative regulation of cell death 321 341 16 16 13 11 9 9 60 332 2146 0.55379 0.58886 1.0 2.64 287877;316351;24567;24426;24404;29739;25283;24890;25612 pycr1;npas2;mt1;gstp1;gpx1;gclm;gclc;esr1;asns PYCR1_9631;NPAS2_9350;MT1A_9255;GSTP1_8762;GPX1_33050;GCLM_8700;GCLC_8699;ESR1_33192;ASNS_8091 165.4787888888889 122.514 6.05608 254.06481275687253 112.6834430502246 159.71868456307578 100.54279111111111 69.2223 2.69961 169.7754153136083 65.81363217308086 104.66803334394069 280.8411444444444 216.573 14.3351 305.45934189729377 219.65170961616988 225.2944608037296 132.668;53.0014;818.334;122.514;8.00432;190.233;145.958;12.5403;6.05608 90.3184;14.3825;540.216;84.8469;2.69961;69.2223;96.7058;3.74981;2.7438 239.858;215.15;988.495;216.573;25.2254;496.452;280.185;51.2968;14.3351 5 4 5 287877;24426;29739;25283;25612 PYCR1_9631;GSTP1_8762;GCLM_8700;GCLC_8699;ASNS_8091 119.48581599999997 132.668 68.47478633051209 68.76744 84.8469 38.284699315692684 249.48062 239.858 172.0512593212325 132.668;122.514;190.233;145.958;6.05608 90.3184;84.8469;69.2223;96.7058;2.7438 239.858;216.573;496.452;280.185;14.3351 4 316351;24567;24404;24890 NPAS2_9350;MT1A_9255;GPX1_33050;ESR1_33192 222.970005 32.770849999999996 397.42442455638127 140.26198 9.066155 266.6882323346599 320.04179999999997 133.2234 453.49478314950153 53.0014;818.334;8.00432;12.5403 14.3825;540.216;2.69961;3.74981 215.15;988.495;25.2254;51.2968 0 Hill,5(0.56);Poly 2,4(0.45) 2.3520638933559903 22.974074006080627 1.7318620681762695 5.5128583908081055 1.2601526036806059 1.90879225730896 -0.5102221122678259 331.4677998900455 -10.377146893779667 211.46272911600184 81.27437440487924 480.4079144840098 CONFLICT 0.5555555555555556 0.4444444444444444 0.0 GO:0007584 4 response to nutrient 144 154 19 19 17 14 13 13 56 141 2337 0.99996 1.7452E-4 1.7452E-4 8.44 24614;59107;24539;116682;24426;116686;24404;29739;25283;25426;24296;24207;114628 orm1;ltbp1;lpl;kynu;gstp1;gsr;gpx1;gclm;gclc;cyp1b1;cyp1a1;apoc3;abcg5 ORM1_9400;LTBP1_33264;LPL_32544;KYNU_8979;GSTP1_8762;GSR_8755;GPX1_33050;GCLM_8700;GCLC_8699;CYP1B1_32710;CYP1A1_8415;APOC3_32553;ABCG5_7947 296.0949253846154 145.958 2.87451 311.97453603242076 233.54788759793826 267.3256276384309 181.65944461538461 84.8469 1.13737 183.43853501086298 150.57515999256083 164.39879943522627 756.34137 280.185 8.23841 1033.6101440978318 529.6261977957411 832.9468935320763 6.5 168.09550000000002 662.49;769.394;900.118;100.381;122.514;69.5519;8.00432;190.233;145.958;229.313;83.0393;2.87451;565.363 432.445;438.027;487.466;72.7231;84.8469;41.1016;2.69961;69.2223;96.7058;185.32;63.0271;1.13737;386.851 1413.32;2211.2;3428.38;161.456;216.573;124.212;25.2254;496.452;280.185;299.27;119.986;8.23841;1047.94 7 6 7 24614;24426;116686;29739;25283;25426;24296 ORM1_9400;GSTP1_8762;GSR_8755;GCLM_8700;GCLC_8699;CYP1B1_32710;CYP1A1_8415 214.72845714285717 145.958 205.32668454093553 138.95267142857142 84.8469 137.3570517620375 421.4282857142857 280.185 455.6169266861194 662.49;122.514;69.5519;190.233;145.958;229.313;83.0393 432.445;84.8469;41.1016;69.2223;96.7058;185.32;63.0271 1413.32;216.573;124.212;496.452;280.185;299.27;119.986 6 59107;24539;116682;24404;24207;114628 LTBP1_33264;LPL_32544;KYNU_8979;GPX1_33050;APOC3_32553;ABCG5_7947 391.02247166666666 332.872 403.6265848396381 231.4840133333333 229.78705 229.31750491004306 1147.0733016666666 604.698 1405.2389393808928 769.394;900.118;100.381;8.00432;2.87451;565.363 438.027;487.466;72.7231;2.69961;1.13737;386.851 2211.2;3428.38;161.456;25.2254;8.23841;1047.94 0 Exp 2,2(0.16);Exp 4,2(0.16);Hill,2(0.16);Linear,3(0.24);Poly 2,4(0.31) 2.182647608664489 32.28715908527374 1.5140434503555298 6.292444229125977 1.5831899934584306 1.7846373319625854 126.50363575724589 465.6862150119848 81.94112107690623 281.3777681538629 194.46449524357456 1318.2182447564255 CONFLICT 0.5384615384615384 0.46153846153846156 0.0 GO:0032869 7 cellular response to insulin stimulus 59 62 7 7 5 6 4 4 65 58 2420 0.9753 0.085045 0.085045 6.45 361042;64194;24426;25283 pck2;insig1;gstp1;gclc PCK2_9440;INSIG1_8906;GSTP1_8762;GCLC_8699 78.2012575 80.0847 6.67763 66.61879402804107 53.688826450695174 66.38869397022684 49.0784375 49.063 1.48195 48.630466294621236 31.466965199834807 46.78320275676262 158.941375 158.81900000000002 37.9425 109.5624986597262 120.66794149497545 113.02288454296429 2.5 134.236 6.67763;37.6554;122.514;145.958 1.48195;13.2791;84.8469;96.7058 37.9425;101.065;216.573;280.185 4 0 4 361042;64194;24426;25283 PCK2_9440;INSIG1_8906;GSTP1_8762;GCLC_8699 78.2012575 80.0847 66.61879402804107 49.0784375 49.063 48.630466294621236 158.941375 158.81900000000002 109.5624986597262 6.67763;37.6554;122.514;145.958 1.48195;13.2791;84.8469;96.7058 37.9425;101.065;216.573;280.185 0 0 Exp 5,1(0.25);Hill,1(0.25);Poly 2,2(0.5) 2.3241843363588086 10.76873505115509 1.528982162475586 5.5128583908081055 1.8889244108338472 1.8634472489356995 12.914839352519763 143.48767564748022 1.4205805312711988 96.7362944687288 51.57012631346835 266.31262368653165 UP 1.0 0.0 0.0 GO:0046883 5 regulation of hormone secretion 83 89 5 5 4 3 2 2 67 87 2391 0.56355 0.70352 1.0 2.25 361042;29200 pck2;inhba PCK2_9440;INHBA_33300 49.244015 49.244015 6.67763 60.197958968194676 32.053627444048466 55.070640229516336 22.820674999999998 22.820674999999998 1.48195 30.177514298749823 14.203054483250177 27.607165781909504 112.43625 112.43625 37.9425 105.35007156203072 82.3520313613685 96.37695344806784 6.67763;91.8104 1.48195;44.1594 37.9425;186.93 1 1 1 361042 PCK2_9440 6.67763 6.67763 1.48195 1.48195 37.9425 37.9425 6.67763 1.48195 37.9425 1 29200 INHBA_33300 91.8104 91.8104 44.1594 44.1594 186.93 186.93 91.8104 44.1594 186.93 0 Hill,2(1) 1.8722120030070377 3.8214731216430664 1.528982162475586 2.2924909591674805 0.5398822476364197 1.9107365608215332 -34.186099600000006 132.67412960000001 -19.003225999999998 64.644576 -33.571499999999986 258.44399999999996 CONFLICT 0.5 0.5 0.0 GO:0051651 4 maintenance of location in cell 23 23 3 3 3 2 2 2 67 21 2457 0.97714 0.12717 0.12717 8.7 170496;64194 lcn2;insig1 LCN2_32481;INSIG1_8906 505.1407 505.1407 37.6554 661.1240514700551 432.20451448887053 653.0280523211483 282.60505 282.60505 13.2791 380.8844111890181 240.58531707543284 376.22017327185034 2092.8175 2092.8175 101.065 2816.763398390518 1782.0679858821106 2782.2698505830617 0.5 505.1407 972.626;37.6554 551.931;13.2791 4084.57;101.065 2 0 2 170496;64194 LCN2_32481;INSIG1_8906 505.1407 505.1407 661.1240514700551 282.60505 282.60505 380.8844111890181 2092.8175 2092.8175 2816.763398390518 972.626;37.6554 551.931;13.2791 4084.57;101.065 0 0 Exp 5,1(0.5);Linear,1(0.5) 1.9109786457658122 3.8235268592834473 1.856990933418274 1.9665359258651733 0.07746000700423171 1.9117634296417236 -411.13048799999996 1421.4118879999999 -245.27381200000002 810.483912 -1811.0173999999993 5996.652399999999 UP 1.0 0.0 0.0 GO:1901362 5 organic cyclic compound biosynthetic process 212 234 19 19 18 9 8 8 61 226 2252 0.8225 0.2975 0.52263 3.42 83472;287877;116682;64194;499709;24890;24296;25748 ugdh;pycr1;kynu;insig1;gar1;esr1;cyp1a1;alas2 UGDH_10131;PYCR1_9631;KYNU_8979;INSIG1_8906;GAR1_8683;ESR1_33192;CYP1A1_8415;ALAS2_8019 499709(-0.07184) 164.565025 91.71015 12.5403 246.27302839710677 107.43922954162684 151.10787274085683 117.67048875 67.8751 3.74981 192.5224898322624 74.11197990122446 117.8935038953578 300.962725 148.262 51.2968 433.61095710718035 196.2201531931358 265.2634353950818 59.3662;132.668;100.381;37.6554;765.364;12.5403;83.0393;125.506 25.4417;90.3184;72.7231;13.2791;587.034;3.74981;63.0271;85.7907 135.068;239.858;161.456;101.065;1362.21;51.2968;119.986;236.762 5 3 5 83472;287877;64194;499709;24296 UGDH_10131;PYCR1_9631;INSIG1_8906;GAR1_8683;CYP1A1_8415 215.61858 83.0393 309.33953461771097 155.82005999999998 63.0271 242.9829752125918 391.6374 135.068 545.2299555956184 59.3662;132.668;37.6554;765.364;83.0393 25.4417;90.3184;13.2791;587.034;63.0271 135.068;239.858;101.065;1362.21;119.986 3 116682;24890;25748 KYNU_8979;ESR1_33192;ALAS2_8019 79.47576666666667 100.381 59.31343801924934 54.08787 72.7231 44.08095683923729 149.83826666666667 161.456 93.27681329576679 100.381;12.5403;125.506 72.7231;3.74981;85.7907 161.456;51.2968;236.762 0 Exp 2,1(0.13);Exp 5,1(0.13);Hill,2(0.25);Poly 2,4(0.5) 2.0659658830526357 18.66523849964142 1.5737498998641968 6.292444229125977 1.6058727780959818 1.7616393566131592 -6.093476834882551 335.22352683488253 -15.740790179484662 251.08176767948467 0.48566179606910964 601.4397882039309 UP 0.625 0.375 0.0 GO:0006749 5 glutathione metabolic process 22 29 10 10 9 8 7 7 62 22 2456 1.0 7.6538E-6 7.6538E-6 24.14 293656;24426;300850;116686;24404;29739;25283 rgd1307603;gstp1;gsta4;gsr;gpx1;gclm;gclc RGD1307603_9684;GSTP1_8762;GSTA4_8757;GSR_8755;GPX1_33050;GCLM_8700;GCLC_8699 129.68210285714287 122.514 8.00432 112.52058909029961 135.9265272785667 120.80030578599175 81.01734428571429 69.2223 2.69961 86.53258587965806 84.99731627475676 93.36169590660526 244.02392857142857 216.573 25.2254 189.02907502389425 253.97629089391984 201.22121759240892 0.5 20.00991 1.5 50.7837 32.0155;122.514;339.498;69.5519;8.00432;190.233;145.958 12.3892;84.8469;260.156;41.1016;2.69961;69.2223;96.7058 78.5761;216.573;486.944;124.212;25.2254;496.452;280.185 5 2 5 24426;300850;116686;29739;25283 GSTP1_8762;GSTA4_8757;GSR_8755;GCLM_8700;GCLC_8699 173.55098000000004 145.958 102.46787027137817 110.40652 84.8469 86.26300275400224 320.8732 280.185 165.54237716276762 122.514;339.498;69.5519;190.233;145.958 84.8469;260.156;41.1016;69.2223;96.7058 216.573;486.944;124.212;496.452;280.185 2 293656;24404 RGD1307603_9684;GPX1_33050 20.00991 20.00991 16.97846820229081 7.544405 7.544405 6.85157479591736 51.90075 51.90075 37.724641751049134 32.0155;8.00432 12.3892;2.69961 78.5761;25.2254 0 Exp 4,2(0.29);Hill,2(0.29);Linear,1(0.15);Poly 2,2(0.29) 2.073135174392528 16.09905517101288 1.567038655281067 5.5128583908081055 1.4204790279821393 1.7846373319625854 46.32568394706519 213.03852176722054 16.91310757425822 145.12158099717035 103.98923011076596 384.0586270320912 UP 0.7142857142857143 0.2857142857142857 0.0 GO:0006475 9 internal protein amino acid acetylation 15 15 1 1 1 1 1 1 68 14 2464 0.93948 0.33842 0.33842 6.67 171142 ehhadh EHHADH_8534 166.899 166.899 166.899 166.899 105.26 105.26 105.26 105.26 384.658 384.658 384.658 384.658 0.0 166.899 166.899 105.26 384.658 0 1 0 1 171142 EHHADH_8534 166.899 166.899 105.26 105.26 384.658 384.658 166.899 105.26 384.658 0 Poly 2,1(1) 1.5039241313934326 1.5039241313934326 1.5039241313934326 1.5039241313934326 0.0 1.5039241313934326 166.899 166.899 105.26 105.26 384.658 384.658 DOWN 0.0 1.0 0.0 GO:0044238 3 primary metabolic process 1157 1278 73 71 62 48 39 39 30 1239 1239 0.88324 0.17195 0.32912 3.05 83472;360243;171497;299270;94195;291317;287877;293820;58835;361042;313108;29685;312538;24539;116682;293502;64194;29200;84029;24426;24404;29739;25283;499709;84586;24890;25315;171142;298452;25426;24296;290277;310395;81508;25612;24207;25748;360887;296925 ugdh;top2a;sgk2;serpina6;s100a9;rpp38;pycr1;psat1;phgdh;pck2;mms22l;mcm6;mcm2;lpl;kynu;kif22;insig1;inhba;hao2;gstp1;gpx1;gclm;gclc;gar1;fgl2;esr1;ephx1;ehhadh;dph2;cyp1b1;cyp1a1;cryl1;noct;bhmt;asns;apoc3;alas2;coq8a;aass UGDH_10131;TOP2A_10059;SGK2_32380;SERPINA6_32325;S100A9_9775;RPP38_9741;PYCR1_9631;PSAT1_9583;PHGDH_9470;PCK2_9440;MMS22L_33129;MCM6_9210;MCM2_9206;LPL_32544;KYNU_8979;KIF22_8963;INSIG1_8906;INHBA_33300;HAO2_8778;GSTP1_8762;GPX1_33050;GCLM_8700;GCLC_8699;GAR1_8683;FGL2_32918;ESR1_33192;EPHX1_8567;EHHADH_8534;DPH2_8490;CYP1B1_32710;CYP1A1_8415;CRYL1_8388;CCRN4L_8232;BHMT_8143;ASNS_8091;APOC3_32553;ALAS2_8019;ADCK3_7987;AASS_7936 499709(-0.07184) 197.2716116923078 91.8104 4.48597E-12 290.43582878980266 155.52281385897768 253.71171132071453 134.33643541025654 63.0271 4.48597E-12 215.09174681173602 104.88136319725457 185.04532628566233 407.07454051282065 161.456 4.48599E-12 669.8276291965132 319.91676297071695 581.7837537511346 59.3662;4.48597E-12;156.37;25.7745;963.318;916.962;132.668;27.1579;122.826;6.67763;4.13516;1.87441;3.76863;900.118;100.381;0.961856;37.6554;91.8104;140.856;122.514;8.00432;190.233;145.958;765.364;146.406;12.5403;27.5708;166.899;734.134;229.313;83.0393;32.8011;665.276;5.5396;6.05608;2.87451;125.506;525.072;5.81076 25.4417;4.48597E-12;100.616;8.17372;802.143;769.912;90.3184;10.0144;67.6778;1.48195;1.24709;0.496857;0.956203;487.466;72.7231;0.281971;13.2791;44.1594;93.5219;84.8469;2.69961;69.2223;96.7058;587.034;95.6156;3.74981;12.6303;105.26;463.289;185.32;63.0271;15.4462;433.686;1.97501;2.7438;1.13737;85.7907;336.426;2.60489 135.068;4.48599E-12;343.205;103.274;1158.68;1051.72;239.858;103.876;246.456;37.9425;20.8956;9.53;22.9217;3428.38;161.456;4.47267;101.065;186.93;282.925;216.573;25.2254;496.452;280.185;1362.21;325.091;51.2968;61.9858;384.658;1764.85;299.27;119.986;74.622;1425.48;37.8319;14.3351;8.23841;236.762;1038.12;14.0792 23 16 23 83472;360243;171497;94195;287877;293820;58835;361042;313108;29685;312538;293502;64194;24426;29739;25283;499709;25315;25426;24296;290277;310395;25612 UGDH_10131;TOP2A_10059;SGK2_32380;S100A9_9775;PYCR1_9631;PSAT1_9583;PHGDH_9470;PCK2_9440;MMS22L_33129;MCM6_9210;MCM2_9206;KIF22_8963;INSIG1_8906;GSTP1_8762;GCLM_8700;GCLC_8699;GAR1_8683;EPHX1_8567;CYP1B1_32710;CYP1A1_8415;CRYL1_8388;CCRN4L_8232;ASNS_8091 164.56106373913062 59.3662 263.737245170945 115.8529074347828 25.4417 207.94193984360012 294.56823347826105 119.986 426.2787277432829 59.3662;4.48597E-12;156.37;963.318;132.668;27.1579;122.826;6.67763;4.13516;1.87441;3.76863;0.961856;37.6554;122.514;190.233;145.958;765.364;27.5708;229.313;83.0393;32.8011;665.276;6.05608 25.4417;4.48597E-12;100.616;802.143;90.3184;10.0144;67.6778;1.48195;1.24709;0.496857;0.956203;0.281971;13.2791;84.8469;69.2223;96.7058;587.034;12.6303;185.32;63.0271;15.4462;433.686;2.7438 135.068;4.48599E-12;343.205;1158.68;239.858;103.876;246.456;37.9425;20.8956;9.53;22.9217;4.47267;101.065;216.573;496.452;280.185;1362.21;61.9858;299.27;119.986;74.622;1425.48;14.3351 16 299270;291317;24539;116682;29200;84029;24404;84586;24890;171142;298452;81508;24207;25748;360887;296925 SERPINA6_32325;RPP38_9741;LPL_32544;KYNU_8979;INHBA_33300;HAO2_8778;GPX1_33050;FGL2_32918;ESR1_33192;EHHADH_8534;DPH2_8490;BHMT_8143;APOC3_32553;ALAS2_8019;ADCK3_7987;AASS_7936 244.29302437500002 112.9435 328.14283220515324 160.906506875 79.2569 229.14617131833197 568.802356875 211.846 907.0871053567053 25.7745;916.962;900.118;100.381;91.8104;140.856;8.00432;146.406;12.5403;166.899;734.134;5.5396;2.87451;125.506;525.072;5.81076 8.17372;769.912;487.466;72.7231;44.1594;93.5219;2.69961;95.6156;3.74981;105.26;463.289;1.97501;1.13737;85.7907;336.426;2.60489 103.274;1051.72;3428.38;161.456;186.93;282.925;25.2254;325.091;51.2968;384.658;1764.85;37.8319;8.23841;236.762;1038.12;14.0792 0 Exp 2,3(0.08);Exp 4,5(0.13);Exp 5,1(0.03);Hill,15(0.39);Linear,3(0.08);Poly 2,12(0.31) 2.0119284127492105 83.78168499469757 1.5039241313934326 6.292444229125977 1.00570896482754 1.7646474838256836 106.1179836889033 288.42523969571226 66.82963655153448 201.84323426897862 196.84834771630332 617.3007333093377 CONFLICT 0.5897435897435898 0.41025641025641024 0.0 GO:0090304 5 nucleic acid metabolic process 251 278 16 16 16 10 10 10 59 268 2210 0.87518 0.21444 0.32667 3.6 360243;291317;313108;29685;312538;293502;499709;24890;25426;310395 top2a;rpp38;mms22l;mcm6;mcm2;kif22;gar1;esr1;cyp1b1;noct TOP2A_10059;RPP38_9741;MMS22L_33129;MCM6_9210;MCM2_9206;KIF22_8963;GAR1_8683;ESR1_33192;CYP1B1_32710;CCRN4L_8232 499709(-0.07184) 260.0195356000005 8.33773 4.48597E-12 372.06173038784937 210.25768128831717 337.7852862449659 198.26839310000042 2.49845 4.48597E-12 291.8739746836412 160.3552086207647 265.40824481417894 424.77967700000045 37.10925 4.48599E-12 603.9327854134443 333.2793413933524 534.8272023634192 4.48597E-12;916.962;4.13516;1.87441;3.76863;0.961856;765.364;12.5403;229.313;665.276 4.48597E-12;769.912;1.24709;0.496857;0.956203;0.281971;587.034;3.74981;185.32;433.686 4.48599E-12;1051.72;20.8956;9.53;22.9217;4.47267;1362.21;51.2968;299.27;1425.48 8 2 8 360243;313108;29685;312538;293502;499709;25426;310395 TOP2A_10059;MMS22L_33129;MCM6_9210;MCM2_9206;KIF22_8963;GAR1_8683;CYP1B1_32710;CCRN4L_8232 208.83663200000055 3.951895 323.39548773693843 151.12776512500056 1.1016465 234.31418192270635 393.0974962500006 21.90865 625.87533800305 4.48597E-12;4.13516;1.87441;3.76863;0.961856;765.364;229.313;665.276 4.48597E-12;1.24709;0.496857;0.956203;0.281971;587.034;185.32;433.686 4.48599E-12;20.8956;9.53;22.9217;4.47267;1362.21;299.27;1425.48 2 291317;24890 RPP38_9741;ESR1_33192 464.75115 464.75115 639.5227171222652 386.83090500000003 386.83090500000003 541.758480037736 551.5084 551.5084 707.4060287763457 916.962;12.5403 769.912;3.74981 1051.72;51.2968 0 Exp 2,1(0.1);Exp 4,2(0.2);Hill,4(0.4);Linear,2(0.2);Poly 2,1(0.1) 1.830782565875629 18.738110423088074 1.5280487537384033 3.1843981742858887 0.48601722440997486 1.7424104809761047 29.413285951019475 490.6257852489814 17.363029353581055 379.17375684641985 50.458258510985615 799.1010954890153 UP 0.8 0.2 0.0 GO:0010608 7 posttranscriptional regulation of gene expression 70 78 5 5 5 4 4 4 65 74 2404 0.9421 0.15875 0.15875 5.13 94195;298452;25426;310395 s100a9;dph2;cyp1b1;noct S100A9_9775;DPH2_8490;CYP1B1_32710;CCRN4L_8232 648.01025 699.7049999999999 229.313 306.83424993783945 518.7075389582803 298.08132027408004 471.1095 448.48749999999995 185.32 253.45643610227498 362.6430869232731 204.30113914217304 1162.0700000000002 1292.08 299.27 626.4087825586947 1007.621932194749 725.0242943991652 2.5 848.726 963.318;734.134;229.313;665.276 802.143;463.289;185.32;433.686 1158.68;1764.85;299.27;1425.48 3 1 3 94195;25426;310395 S100A9_9775;CYP1B1_32710;CCRN4L_8232 619.3023333333333 665.276 369.15581876266475 473.7163333333333 433.686 310.3537884774945 961.1433333333334 1158.68 588.5174526157513 963.318;229.313;665.276 802.143;185.32;433.686 1158.68;299.27;1425.48 1 298452 DPH2_8490 734.134 734.134 463.289 463.289 1764.85 1764.85 734.134 463.289 1764.85 0 Linear,3(0.75);Poly 2,1(0.25) 2.002493047959331 8.332050085067749 1.6845101118087769 3.1843981742858887 0.7348974437456848 1.7315708994865417 347.31268506091715 948.7078149390829 222.72219261977042 719.4968073802296 548.1893930924788 1775.950606907521 UP 0.75 0.25 0.0 GO:0006996 5 organelle organization 397 425 22 21 21 9 9 9 60 416 2062 0.2615 0.83817 0.51293 2.12 360243;94195;29685;312538;293502;29739;25283;499709;310395 top2a;s100a9;mcm6;mcm2;kif22;gclm;gclc;gar1;noct TOP2A_10059;S100A9_9775;MCM6_9210;MCM2_9206;KIF22_8963;GCLM_8700;GCLC_8699;GAR1_8683;CCRN4L_8232 499709(-0.07184) 304.0837662222227 145.958 4.48597E-12 384.32803681911287 197.70473090891628 313.48828846847493 221.16957011111163 69.2223 4.48597E-12 306.1917346170584 132.62367591607602 232.8730227063666 528.8812633333338 280.185 4.48599E-12 616.2704959158814 387.54659508648683 574.7509239017119 4.48597E-12;963.318;1.87441;3.76863;0.961856;190.233;145.958;765.364;665.276 4.48597E-12;802.143;0.496857;0.956203;0.281971;69.2223;96.7058;587.034;433.686 4.48599E-12;1158.68;9.53;22.9217;4.47267;496.452;280.185;1362.21;1425.48 9 0 9 360243;94195;29685;312538;293502;29739;25283;499709;310395 TOP2A_10059;S100A9_9775;MCM6_9210;MCM2_9206;KIF22_8963;GCLM_8700;GCLC_8699;GAR1_8683;CCRN4L_8232 304.0837662222227 145.958 384.32803681911287 221.16957011111163 69.2223 306.1917346170584 528.8812633333338 280.185 616.2704959158814 4.48597E-12;963.318;1.87441;3.76863;0.961856;190.233;145.958;765.364;665.276 4.48597E-12;802.143;0.496857;0.956203;0.281971;69.2223;96.7058;587.034;433.686 4.48599E-12;1158.68;9.53;22.9217;4.47267;496.452;280.185;1362.21;1425.48 0 0 Exp 2,1(0.12);Exp 4,1(0.12);Hill,4(0.45);Linear,1(0.12);Poly 2,2(0.23) 1.7653388434370967 15.946375846862793 1.5280487537384033 2.092013359069824 0.16252021137540443 1.7575112581253052 52.98944883373568 555.1780836107099 21.12430349463338 421.21483672758984 126.25120600162467 931.5113206650428 UP 1.0 0.0 0.0 GO:0006810 4 transport 570 605 23 22 19 13 9 9 60 596 1882 0.019391 0.99172 0.031805 1.49 266730;287167;170496;29200;360504;24207;301111;25748;114628 slc17a3;hba-a1;lcn2;inhba;hba-a2;apoc3;ano10;alas2;abcg5 SLC17A3_9840;LOC287167_9118;LCN2_32481;INHBA_33300;HBA2_32600;APOC3_32553;ANO10_8049;ALAS2_8019;ABCG5_7947 237.9796122222222 125.506 2.87451 321.7909559457131 231.21762880172307 299.3784648333829 147.4787077777778 85.7907 1.13737 190.34865560243273 147.90740158882514 184.05653237683643 703.2624122222223 236.762 8.23841 1304.7835865142372 603.6069091903051 1102.7312084631849 93.3839;149.282;972.626;91.8104;131.05;2.87451;9.9207;125.506;565.363 68.9252;97.0024;551.931;44.1594;88.5948;1.13737;2.9165;85.7907;386.851 143.418;334.152;4084.57;186.93;254.163;8.23841;33.1883;236.762;1047.94 3 6 3 266730;170496;301111 SLC17A3_9840;LCN2_32481;ANO10_8049 358.6435333333333 93.3839 533.359520838546 207.92423333333332 68.9252 299.7411862812039 1420.3921 143.418 2307.9039318885934 93.3839;972.626;9.9207 68.9252;551.931;2.9165 143.418;4084.57;33.1883 6 287167;29200;360504;24207;25748;114628 LOC287167_9118;INHBA_33300;HBA2_32600;APOC3_32553;ALAS2_8019;ABCG5_7947 177.64765166666666 128.27800000000002 196.94241763968077 117.255945 87.19275 136.91592383072816 344.6975683333333 245.4625 361.27637413117674 149.282;91.8104;131.05;2.87451;125.506;565.363 97.0024;44.1594;88.5948;1.13737;85.7907;386.851 334.152;186.93;254.163;8.23841;236.762;1047.94 0 Exp 4,1(0.12);Hill,2(0.23);Linear,2(0.23);Poly 2,4(0.45) 1.7620279763672497 15.986209273338318 1.504341721534729 2.2924909591674805 0.24550608493655057 1.7586312294006348 27.74285433768975 448.21637010675477 23.117586117521753 271.83982943803386 -149.19619763374612 1555.7210220781908 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0050878 4 regulation of body fluid levels 107 110 6 6 5 4 3 3 66 107 2371 0.65207 0.58016 1.0 2.73 94195;288001;25748 s100a9;kng1;alas2 S100A9_9775;KNG1L1_32433;ALAS2_8019 288001(0.1788) 364.23318666666665 125.506 3.87556 522.3748186490468 228.9868115282097 445.04583072001026 296.39627 85.7907 1.25511 440.02429782164495 183.61795180475343 373.5561394421674 469.75980000000004 236.762 13.8374 606.9449116660588 307.8402346734785 524.0219564497761 963.318;3.87556;125.506 802.143;1.25511;85.7907 1158.68;13.8374;236.762 2 1 2 94195;288001 S100A9_9775;KNG1L1_32433 483.59677999999997 483.59677999999997 678.4282554821673 401.699055 401.699055 566.3132579891858 586.2587 586.2587 809.5259658512382 963.318;3.87556 802.143;1.25511 1158.68;13.8374 1 25748 ALAS2_8019 125.506 125.506 85.7907 85.7907 236.762 236.762 125.506 85.7907 236.762 0 Exp 4,1(0.34);Poly 2,2(0.67) 1.6781573045271465 5.0398337841033936 1.5755720138549805 1.7586312294006348 0.0941939221560177 1.7056305408477783 -226.88956797655527 955.3559413098885 -201.53809772271347 794.3306377227135 -217.06302394199855 1156.5826239419985 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0046700 5 heterocycle catabolic process 52 63 6 6 6 4 4 4 65 59 2419 0.97372 0.08903 0.08903 6.35 116682;24296;310395;26760 kynu;cyp1a1;noct;akr7a3 KYNU_8979;CYP1A1_8415;CCRN4L_8232;AKR7A3_8015 226.45325 91.71015 57.1167 293.0881814733863 237.0879167429094 297.53902171195136 150.6257 67.8751 33.0666 189.4602906834921 158.88237296847709 191.22112825041853 452.46775 140.721 102.949 649.1399818151064 471.8658256674707 662.2063354748699 2.5 382.82849999999996 100.381;83.0393;665.276;57.1167 72.7231;63.0271;433.686;33.0666 161.456;119.986;1425.48;102.949 3 1 3 24296;310395;26760 CYP1A1_8415;CCRN4L_8232;AKR7A3_8015 268.4773333333333 83.0393 343.88207528020894 176.5932333333333 63.0271 223.15224823941014 549.4716666666667 119.986 758.6932943517646 83.0393;665.276;57.1167 63.0271;433.686;33.0666 119.986;1425.48;102.949 1 116682 KYNU_8979 100.381 100.381 72.7231 72.7231 161.456 161.456 100.381 72.7231 161.456 0 Hill,1(0.25);Linear,1(0.25);Poly 2,2(0.5) 3.2579971148291285 15.212039589881897 1.7575112581253052 6.292444229125977 2.2914175239395154 3.5810420513153076 -60.77316784391854 513.6796678439187 -35.04538486982227 336.29678486982226 -183.68943217880422 1088.624932178804 UP 0.75 0.25 0.0 GO:0010941 5 regulation of cell death 479 511 28 28 24 17 14 14 55 497 1981 0.59004 0.53016 1.0 2.74 360243;94195;287877;316351;24567;29200;360504;24426;24404;29739;25283;24890;25426;25612 top2a;s100a9;pycr1;npas2;mt1;inhba;hba-a2;gstp1;gpx1;gclm;gclc;esr1;cyp1b1;asns TOP2A_10059;S100A9_9775;PYCR1_9631;NPAS2_9350;MT1A_9255;INHBA_33300;HBA2_32600;GSTP1_8762;GPX1_33050;GCLM_8700;GCLC_8699;ESR1_33192;CYP1B1_32710;ASNS_8091 207.48575000000028 126.78200000000001 4.48597E-12 299.5259153545768 143.80535227852164 193.37373429752995 144.65016571428603 77.03460000000001 4.48597E-12 234.71976886147453 98.48224394364739 152.5067397349898 316.1866642857146 228.21550000000002 4.48599E-12 349.53776614415847 239.43892784758359 242.71152434248916 4.48597E-12;963.318;132.668;53.0014;818.334;91.8104;131.05;122.514;8.00432;190.233;145.958;12.5403;229.313;6.05608 4.48597E-12;802.143;90.3184;14.3825;540.216;44.1594;88.5948;84.8469;2.69961;69.2223;96.7058;3.74981;185.32;2.7438 4.48599E-12;1158.68;239.858;215.15;988.495;186.93;254.163;216.573;25.2254;496.452;280.185;51.2968;299.27;14.3351 8 6 8 360243;94195;287877;24426;29739;25283;25426;25612 TOP2A_10059;S100A9_9775;PYCR1_9631;GSTP1_8762;GCLM_8700;GCLC_8699;CYP1B1_32710;ASNS_8091 223.75751000000054 139.313 309.41560617667704 166.41252500000056 87.58265 263.42240491042236 338.1691375000006 260.0215 367.7818439071214 4.48597E-12;963.318;132.668;122.514;190.233;145.958;229.313;6.05608 4.48597E-12;802.143;90.3184;84.8469;69.2223;96.7058;185.32;2.7438 4.48599E-12;1158.68;239.858;216.573;496.452;280.185;299.27;14.3351 6 316351;24567;29200;360504;24404;24890 NPAS2_9350;MT1A_9255;INHBA_33300;HBA2_32600;GPX1_33050;ESR1_33192 185.79007000000001 72.4059 313.43151201027723 115.63368666666668 29.27095 210.53917743455213 286.8767 201.04000000000002 355.6492034215907 53.0014;818.334;91.8104;131.05;8.00432;12.5403 14.3825;540.216;44.1594;88.5948;2.69961;3.74981 215.15;988.495;186.93;254.163;25.2254;51.2968 0 Hill,7(0.5);Linear,1(0.08);Poly 2,6(0.43) 2.2652514631679286 33.857584834098816 1.7056305408477783 5.5128583908081055 1.0612347184152764 1.9284122586250305 50.58448047966533 364.3870195203353 21.69643173674885 267.60389969182324 133.08758523474916 499.28574333668 CONFLICT 0.5714285714285714 0.42857142857142855 0.0 GO:0032879 4 regulation of localization 652 690 32 32 26 19 14 14 55 676 1802 0.12315 0.92662 0.21857 2.03 94195;361042;24614;24539;64194;29200;25663;24426;25283;25317;24890;25426;24207;114628 s100a9;pck2;orm1;lpl;insig1;inhba;il1r1;gstp1;gclc;fgf1;esr1;cyp1b1;apoc3;abcg5 S100A9_9775;PCK2_9440;ORM1_9400;LPL_32544;INSIG1_8906;INHBA_33300;IL1R1_8893;GSTP1_8762;GCLC_8699;FGF1_8633;ESR1_33192;CYP1B1_32710;APOC3_32553;ABCG5_7947 320.81543142857146 134.236 2.87451 352.4777236931763 262.9729588910884 309.454858846412 214.62348785714286 90.77635000000001 1.13737 250.8665570312867 173.64800839656553 208.4584234968855 705.7116935714286 248.37900000000002 8.23841 947.2366002063161 573.9396420741541 824.9696436274429 963.318;6.67763;662.49;900.118;37.6554;91.8104;76.6218;122.514;145.958;674.162;12.5403;229.313;2.87451;565.363 802.143;1.48195;432.445;487.466;13.2791;44.1594;27.5215;84.8469;96.7058;437.622;3.74981;185.32;1.13737;386.851 1158.68;37.9425;1413.32;3428.38;101.065;186.93;185.143;216.573;280.185;1465.0;51.2968;299.27;8.23841;1047.94 9 5 9 94195;361042;24614;64194;25663;24426;25283;25317;25426 S100A9_9775;PCK2_9440;ORM1_9400;INSIG1_8906;IL1R1_8893;GSTP1_8762;GCLC_8699;FGF1_8633;CYP1B1_32710 324.3010922222222 145.958 348.39981985053475 231.26280555555553 96.7058 272.1312166228987 573.0198333333333 280.185 590.7594613814915 963.318;6.67763;662.49;37.6554;76.6218;122.514;145.958;674.162;229.313 802.143;1.48195;432.445;13.2791;27.5215;84.8469;96.7058;437.622;185.32 1158.68;37.9425;1413.32;101.065;185.143;216.573;280.185;1465.0;299.27 5 24539;29200;24890;24207;114628 LPL_32544;INHBA_33300;ESR1_33192;APOC3_32553;ABCG5_7947 314.54124200000007 91.8104 401.17372875678103 184.67271599999998 44.1594 233.83869679590552 944.557042 186.93 1451.6085644923894 900.118;91.8104;12.5403;2.87451;565.363 487.466;44.1594;3.74981;1.13737;386.851 3428.38;186.93;51.2968;8.23841;1047.94 0 Exp 2,1(0.08);Exp 4,1(0.08);Exp 5,1(0.08);Hill,4(0.29);Linear,4(0.29);Poly 2,3(0.22) 1.9559628929705775 29.506256699562073 1.5235437154769897 5.5128583908081055 1.0723583038424886 1.718746304512024 136.17630843439417 505.45455442274874 83.21154898765045 346.03542672663525 209.51881846558496 1201.9045686772724 UP 0.6428571428571429 0.35714285714285715 0.0 GO:0050769 7 positive regulation of neurogenesis 132 142 6 6 6 3 3 3 66 139 2339 0.45674 0.75087 1.0 2.11 192247;94195;25663 sez6;s100a9;il1r1 SEZ6_9819;S100A9_9775;IL1R1_8893 350.193 76.6218 10.6392 532.0057566365613 195.27960490048815 417.27396957074603 277.87499 27.5215 3.96047 454.1822214328576 144.70596640912507 356.02837405431706 457.77423333333337 185.143 29.4997 611.970489091315 282.4064388753286 482.1381233814008 10.6392;963.318;76.6218 3.96047;802.143;27.5215 29.4997;1158.68;185.143 2 1 2 94195;25663 S100A9_9775;IL1R1_8893 519.9698999999999 519.9698999999999 626.9888958723433 414.83225 414.83225 547.7401155028953 671.9115 671.9115 688.394614436008 963.318;76.6218 802.143;27.5215 1158.68;185.143 1 192247 SEZ6_9819 10.6392 10.6392 3.96047 3.96047 29.4997 29.4997 10.6392 3.96047 29.4997 0 Hill,2(0.67);Poly 2,1(0.34) 2.211997158833903 7.146533966064453 1.6931662559509277 3.747737169265747 1.1826253617880491 1.7056305408477783 -251.82818693691638 952.2141869369163 -236.08057649858893 791.830556498589 -234.73556682810295 1150.2840334947696 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0051046 6 regulation of secretion 220 238 12 12 10 7 5 5 64 233 2245 0.36333 0.78778 0.67739 2.1 94195;361042;24614;24539;29200 s100a9;pck2;orm1;lpl;inhba S100A9_9775;PCK2_9440;ORM1_9400;LPL_32544;INHBA_33300 524.882806 662.49 6.67763 449.45826370932616 318.3033268565625 442.6069666434472 353.53907 432.445 1.48195 333.5671035683218 200.5024105258298 298.41056644484564 1245.0505 1158.68 37.9425 1358.2553984482263 869.8704593509073 1389.0429581925423 963.318;6.67763;662.49;900.118;91.8104 802.143;1.48195;432.445;487.466;44.1594 1158.68;37.9425;1413.32;3428.38;186.93 3 2 3 94195;361042;24614 S100A9_9775;PCK2_9440;ORM1_9400 544.1618766666667 662.49 489.17415912650733 412.0233166666667 432.445 400.72099160064084 869.9808333333334 1158.68 731.7282442970773 963.318;6.67763;662.49 802.143;1.48195;432.445 1158.68;37.9425;1413.32 2 24539;29200 LPL_32544;INHBA_33300 495.9642 495.9642 571.5597852446235 265.8127 265.8127 313.4651030047524 1807.655 1807.655 2292.0512758771342 900.118;91.8104 487.466;44.1594 3428.38;186.93 0 Exp 2,1(0.2);Hill,2(0.4);Linear,1(0.2);Poly 2,1(0.2) 1.7361750542417562 8.779542922973633 1.528982162475586 2.2924909591674805 0.3112777930342802 1.7036563158035278 130.91526756439254 918.8503444356074 61.15461229449977 645.9235277055002 54.48715051937188 2435.6138494806282 UP 0.6 0.4 0.0 GO:0006139 4 nucleobase-containing compound metabolic process 359 401 22 22 22 13 13 13 56 388 2090 0.81394 0.28316 0.50139 3.24 83472;360243;291317;313108;29685;312538;116682;293502;499709;24890;25426;310395;296925 ugdh;top2a;rpp38;mms22l;mcm6;mcm2;kynu;kif22;gar1;esr1;cyp1b1;noct;aass UGDH_10131;TOP2A_10059;RPP38_9741;MMS22L_33129;MCM6_9210;MCM2_9206;KYNU_8979;KIF22_8963;GAR1_8683;ESR1_33192;CYP1B1_32710;CCRN4L_8232;AASS_7936 499709(-0.07184) 212.75025507692342 12.5403 4.48597E-12 335.06102705894926 175.7174955233307 305.82321450446625 160.26566315384648 3.74981 4.48597E-12 263.2891233206961 132.66975905702623 240.48219979816776 350.6461515384618 51.2968 4.48599E-12 542.6106066490436 281.1077099471399 483.1937210806139 59.3662;4.48597E-12;916.962;4.13516;1.87441;3.76863;100.381;0.961856;765.364;12.5403;229.313;665.276;5.81076 25.4417;4.48597E-12;769.912;1.24709;0.496857;0.956203;72.7231;0.281971;587.034;3.74981;185.32;433.686;2.60489 135.068;4.48599E-12;1051.72;20.8956;9.53;22.9217;161.456;4.47267;1362.21;51.2968;299.27;1425.48;14.0792 9 4 9 83472;360243;313108;29685;312538;293502;499709;25426;310395 UGDH_10131;TOP2A_10059;MMS22L_33129;MCM6_9210;MCM2_9206;KIF22_8963;GAR1_8683;CYP1B1_32710;CCRN4L_8232 192.22880622222272 4.13516 306.5843117253735 137.16264677777826 1.24709 223.14897410230472 364.4275522222227 22.9217 591.7369665614794 59.3662;4.48597E-12;4.13516;1.87441;3.76863;0.961856;765.364;229.313;665.276 25.4417;4.48597E-12;1.24709;0.496857;0.956203;0.281971;587.034;185.32;433.686 135.068;4.48599E-12;20.8956;9.53;22.9217;4.47267;1362.21;299.27;1425.48 4 291317;116682;24890;296925 RPP38_9741;KYNU_8979;ESR1_33192;AASS_7936 258.923515 56.46065 440.8027269202732 212.24745000000001 38.236455 373.219356151557 319.63800000000003 106.37639999999999 492.04971961611085 916.962;100.381;12.5403;5.81076 769.912;72.7231;3.74981;2.60489 1051.72;161.456;51.2968;14.0792 0 Exp 2,1(0.08);Exp 4,2(0.16);Hill,6(0.47);Linear,2(0.16);Poly 2,2(0.16) 1.8539121949372166 24.614423751831055 1.5280487537384033 3.1843981742858887 0.4509296749208275 1.75295889377594 30.60900596903798 394.89150418480887 17.140065351287035 303.391260956406 55.679665755989106 645.6126373209347 UP 0.6923076923076923 0.3076923076923077 0.0 GO:0002439 5 chronic inflammatory response to antigenic stimulus 2 3 1 1 1 1 1 1 68 2 2476 0.99787 0.07912 0.07912 33.33 24614 orm1 ORM1_9400 662.49 662.49 662.49 662.49 432.445 432.445 432.445 432.445 1413.32 1413.32 1413.32 1413.32 0.0 662.49 0.0 662.49 662.49 432.445 1413.32 1 0 1 24614 ORM1_9400 662.49 662.49 432.445 432.445 1413.32 1413.32 662.49 432.445 1413.32 0 0 Linear,1(1) 1.5487829446792603 1.5487829446792603 1.5487829446792603 1.5487829446792603 0.0 1.5487829446792603 662.49 662.49 432.445 432.445 1413.32 1413.32 UP 1.0 0.0 0.0 GO:0009416 5 response to light stimulus 83 88 6 6 4 4 2 2 67 86 2392 0.57086 0.69752 1.0 2.27 24404;25612 gpx1;asns GPX1_33050;ASNS_8091 7.0302 7.0302 6.05608 1.3776137153788746 7.299500232781634 1.3239238339298356 2.721705 2.721705 2.69961 0.031247048660574088 2.715596729311265 0.030029254209644363 19.780250000000002 19.780250000000002 14.3351 7.700604979155855 21.285588318206084 7.400488506881237 8.00432;6.05608 2.69961;2.7438 25.2254;14.3351 1 1 1 25612 ASNS_8091 6.05608 6.05608 2.7438 2.7438 14.3351 14.3351 6.05608 2.7438 14.3351 1 24404 GPX1_33050 8.00432 8.00432 2.69961 2.69961 25.2254 25.2254 8.00432 2.69961 25.2254 0 Hill,2(1) 2.510802014398045 5.317078709602356 1.7846373319625854 3.5324413776397705 1.23588409288362 2.658539354801178 5.1209248 8.9394752 2.6783988 2.7650112 9.107756000000004 30.452744000000003 CONFLICT 0.5 0.5 0.0 GO:0046916 9 cellular transition metal ion homeostasis 20 23 2 2 2 2 2 2 67 21 2457 0.97714 0.12717 0.12717 8.7 24567;25748 mt1;alas2 MT1A_9255;ALAS2_8019 471.91999999999996 471.91999999999996 125.506 489.90337699591333 344.1324415463438 455.35260908542807 313.00335 313.00335 85.7907 321.32721117273115 229.18759834653005 298.6653916836912 612.6285 612.6285 236.762 531.5555019417069 473.9763025151374 494.0671896713416 0.5 471.91999999999996 818.334;125.506 540.216;85.7907 988.495;236.762 0 2 0 2 24567;25748 MT1A_9255;ALAS2_8019 471.91999999999996 471.91999999999996 489.90337699591333 313.00335 313.00335 321.32721117273115 612.6285 612.6285 531.5555019417069 818.334;125.506 540.216;85.7907 988.495;236.762 0 Poly 2,2(1) 2.027369600373731 4.095805406570435 1.7586312294006348 2.3371741771698 0.4090916415752312 2.0479027032852173 -207.05143999999996 1150.8914399999999 -132.33344399999993 758.340144 -124.06983999999989 1349.32684 DOWN 0.0 1.0 0.0 GO:0051186 4 cofactor metabolic process 111 126 24 24 20 20 16 16 53 110 2368 1.0 1.0311E-7 1.0311E-7 12.7 293656;680308;287167;116682;360504;24426;300850;116686;24404;29739;25283;24296;81508;25748;360887;296925 rgd1307603;mthfd2;hba-a1;kynu;hba-a2;gstp1;gsta4;gsr;gpx1;gclm;gclc;cyp1a1;bhmt;alas2;coq8a;aass RGD1307603_9684;MTHFD2_9261;LOC287167_9118;KYNU_8979;HBA2_32600;GSTP1_8762;GSTA4_8757;GSR_8755;GPX1_33050;GCLM_8700;GCLC_8699;CYP1A1_8415;BHMT_8143;ALAS2_8019;ADCK3_7987;AASS_7936 166.00221125 124.00999999999999 5.5396 180.431601895144 132.80159975873124 148.00702026295892 108.09571312499999 78.785 1.97501 121.82176632539239 86.78183207756469 101.23456709537608 322.187975 226.66750000000002 14.0792 354.5578693678471 255.13738639607882 286.2366491810019 5.5 91.71015 11.5 169.7575 32.0155;622.58;149.282;100.381;131.05;122.514;339.498;69.5519;8.00432;190.233;145.958;83.0393;5.5396;125.506;525.072;5.81076 12.3892;414.266;97.0024;72.7231;88.5948;84.8469;260.156;41.1016;2.69961;69.2223;96.7058;63.0271;1.97501;85.7907;336.426;2.60489 78.5761;1250.29;334.152;161.456;254.163;216.573;486.944;124.212;25.2254;496.452;280.185;119.986;37.8319;236.762;1038.12;14.0792 7 9 7 680308;24426;300850;116686;29739;25283;24296 MTHFD2_9261;GSTP1_8762;GSTA4_8757;GSR_8755;GCLM_8700;GCLC_8699;CYP1A1_8415 224.76774285714288 145.958 197.25448249551354 147.04652857142858 84.8469 138.40952761350056 424.9488571428571 280.185 395.38297318862396 622.58;122.514;339.498;69.5519;190.233;145.958;83.0393 414.266;84.8469;260.156;41.1016;69.2223;96.7058;63.0271 1250.29;216.573;486.944;124.212;496.452;280.185;119.986 9 293656;287167;116682;360504;24404;81508;25748;360887;296925 RGD1307603_9684;LOC287167_9118;KYNU_8979;HBA2_32600;GPX1_33050;BHMT_8143;ALAS2_8019;ADCK3_7987;AASS_7936 120.29568666666667 100.381 162.7505636735271 77.80063444444444 72.7231 105.3474423968622 242.26284444444445 161.456 319.43157273796567 32.0155;149.282;100.381;131.05;8.00432;5.5396;125.506;525.072;5.81076 12.3892;97.0024;72.7231;88.5948;2.69961;1.97501;85.7907;336.426;2.60489 78.5761;334.152;161.456;254.163;25.2254;37.8319;236.762;1038.12;14.0792 0 Exp 2,1(0.07);Exp 4,3(0.19);Hill,3(0.19);Linear,2(0.13);Poly 2,7(0.44) 2.0717056829595415 36.93143427371979 1.5278362035751343 6.292444229125977 1.4233671017445046 1.7724979519844055 77.59072632137945 254.41369617862057 48.40304762555774 167.78837862444226 148.45461900975485 495.921330990245 CONFLICT 0.4375 0.5625 0.0 GO:0043604 6 amide biosynthetic process 50 60 4 4 4 4 4 4 65 56 2422 0.97827 0.07735 0.07735 6.67 84029;29739;25283;25612 hao2;gclm;gclc;asns HAO2_8778;GCLM_8700;GCLC_8699;ASNS_8091 120.77577000000001 143.40699999999998 6.05608 79.6288775457639 130.79123705485281 74.02003999993983 65.54845 81.3721 2.7438 43.63185227701585 69.88952875375801 40.00481051649058 268.47427500000003 281.555 14.3351 197.40527508901363 292.8011305689489 189.96466633984377 2.0 145.958 140.856;190.233;145.958;6.05608 93.5219;69.2223;96.7058;2.7438 282.925;496.452;280.185;14.3351 3 1 3 29739;25283;25612 GCLM_8700;GCLC_8699;ASNS_8091 114.08236 145.958 96.13702088284617 56.22396666666666 69.2223 48.31078412821856 263.65736666666663 280.185 241.48301868682887 190.233;145.958;6.05608 69.2223;96.7058;2.7438 496.452;280.185;14.3351 1 84029 HAO2_8778 140.856 140.856 93.5219 93.5219 282.925 282.925 140.856 93.5219 282.925 0 Hill,2(0.5);Poly 2,2(0.5) 2.23993758016938 9.322437047958374 1.7603585720062256 3.5324413776397705 0.8147631519617823 2.014818549156189 42.73947000515136 198.81206999484866 22.78923476852446 108.30766523147554 75.0171054127666 461.9314445872334 UP 0.75 0.25 0.0 GO:1901700 4 response to oxygen-containing compound 599 638 52 52 41 34 24 24 45 614 1864 0.97599 0.043298 0.066761 3.76 94195;361042;24614;24567;59107;24539;170496;64194;29200;25663;360504;24426;116686;24404;29739;25283;24890;25426;24296;310395;54232;25612;24207;25748 s100a9;pck2;orm1;mt1;ltbp1;lpl;lcn2;insig1;inhba;il1r1;hba-a2;gstp1;gsr;gpx1;gclm;gclc;esr1;cyp1b1;cyp1a1;noct;car3;asns;apoc3;alas2 S100A9_9775;PCK2_9440;ORM1_9400;MT1A_9255;LTBP1_33264;LPL_32544;LCN2_32481;INSIG1_8906;INHBA_33300;IL1R1_8893;HBA2_32600;GSTP1_8762;GSR_8755;GPX1_33050;GCLM_8700;GCLC_8699;ESR1_33192;CYP1B1_32710;CYP1A1_8415;CCRN4L_8232;CAR3_8196;ASNS_8091;APOC3_32553;ALAS2_8019 295.60045708333337 124.00999999999999 2.87451 356.0650320513015 206.15796726449264 297.50307116472266 187.47613208333328 77.03460000000001 1.13737 235.94584228128673 129.1445392847569 189.080129143951 723.0802225000001 226.66750000000002 6.02113 1099.8838257904267 524.6764405594733 982.5511397734093 963.318;6.67763;662.49;818.334;769.394;900.118;972.626;37.6554;91.8104;76.6218;131.05;122.514;69.5519;8.00432;190.233;145.958;12.5403;229.313;83.0393;665.276;3.44933;6.05608;2.87451;125.506 802.143;1.48195;432.445;540.216;438.027;487.466;551.931;13.2791;44.1594;27.5215;88.5948;84.8469;41.1016;2.69961;69.2223;96.7058;3.74981;185.32;63.0271;433.686;2.13143;2.7438;1.13737;85.7907 1158.68;37.9425;1413.32;988.495;2211.2;3428.38;4084.57;101.065;186.93;185.143;254.163;216.573;124.212;25.2254;496.452;280.185;51.2968;299.27;119.986;1425.48;6.02113;14.3351;8.23841;236.762 14 10 14 94195;361042;24614;170496;64194;25663;24426;116686;29739;25283;25426;24296;310395;25612 S100A9_9775;PCK2_9440;ORM1_9400;LCN2_32481;INSIG1_8906;IL1R1_8893;GSTP1_8762;GSR_8755;GCLM_8700;GCLC_8699;CYP1B1_32710;CYP1A1_8415;CCRN4L_8232;ASNS_8091 302.237865 134.236 353.0950444402348 200.38964642857144 77.03460000000001 251.65006023797022 711.2295428571427 248.37900000000002 1092.3246445156572 963.318;6.67763;662.49;972.626;37.6554;76.6218;122.514;69.5519;190.233;145.958;229.313;83.0393;665.276;6.05608 802.143;1.48195;432.445;551.931;13.2791;27.5215;84.8469;41.1016;69.2223;96.7058;185.32;63.0271;433.686;2.7438 1158.68;37.9425;1413.32;4084.57;101.065;185.143;216.573;124.212;496.452;280.185;299.27;119.986;1425.48;14.3351 10 24567;59107;24539;29200;360504;24404;24890;54232;24207;25748 MT1A_9255;LTBP1_33264;LPL_32544;INHBA_33300;HBA2_32600;GPX1_33050;ESR1_33192;CAR3_8196;APOC3_32553;ALAS2_8019 286.308086 108.6582 379.13987050490243 169.397212 64.97505 223.9931167550345 739.671174 211.846 1169.4325537994828 818.334;769.394;900.118;91.8104;131.05;8.00432;12.5403;3.44933;2.87451;125.506 540.216;438.027;487.466;44.1594;88.5948;2.69961;3.74981;2.13143;1.13737;85.7907 988.495;2211.2;3428.38;186.93;254.163;25.2254;51.2968;6.02113;8.23841;236.762 0 Exp 2,2(0.09);Exp 4,3(0.13);Exp 5,1(0.05);Hill,7(0.3);Linear,4(0.17);Poly 2,7(0.3) 2.1954245805314927 59.41470229625702 1.5140434503555298 6.759152412414551 1.5244947962645425 1.798611342906952 153.14477526700708 438.0561388996598 93.07813506500962 281.87412910165705 283.03504474396095 1163.1254002560395 CONFLICT 0.5833333333333334 0.4166666666666667 0.0 GO:0042592 4 homeostatic process 357 379 29 29 25 20 17 17 52 362 2116 0.9902 0.021002 0.02598 4.49 361042;259241;24567;24539;288001;64194;25663;116686;24404;29739;25283;499709;24890;117517;24207;25748;114628 pck2;nr1d2;mt1;lpl;kng1;insig1;il1r1;gsr;gpx1;gclm;gclc;gar1;esr1;c7;apoc3;alas2;abcg5 PCK2_9440;NR1D2_9358;MT1A_9255;LPL_32544;KNG1L1_32433;INSIG1_8906;IL1R1_8893;GSR_8755;GPX1_33050;GCLM_8700;GCLC_8699;GAR1_8683;ESR1_33192;C7_8179;APOC3_32553;ALAS2_8019;ABCG5_7947 288001(0.1788);499709(-0.07184) 225.99975470588234 76.6218 2.87451 317.5635544806916 154.36127496870682 252.952732842545 140.02685588235295 32.7314 1.13737 211.4859250586278 91.53954852652815 165.16070055084376 513.5639476470589 185.143 8.23841 856.4334810631518 370.06996845483303 702.2635535540662 6.67763;9.46041;818.334;900.118;3.87556;37.6554;76.6218;69.5519;8.00432;190.233;145.958;765.364;12.5403;103.858;2.87451;125.506;565.363 1.48195;2.2133;540.216;487.466;1.25511;13.2791;27.5215;41.1016;2.69961;69.2223;96.7058;587.034;3.74981;32.7314;1.13737;85.7907;386.851 37.9425;49.4216;988.495;3428.38;13.8374;101.065;185.143;124.212;25.2254;496.452;280.185;1362.21;51.2968;293.781;8.23841;236.762;1047.94 9 8 9 361042;259241;288001;64194;25663;116686;29739;25283;499709 PCK2_9440;NR1D2_9358;KNG1L1_32433;INSIG1_8906;IL1R1_8893;GSR_8755;GCLM_8700;GCLC_8699;GAR1_8683 145.0441888888889 69.5519 241.40459818999605 93.31274 27.5215 188.0887516126317 294.49649999999997 124.212 427.7886302147826 6.67763;9.46041;3.87556;37.6554;76.6218;69.5519;190.233;145.958;765.364 1.48195;2.2133;1.25511;13.2791;27.5215;41.1016;69.2223;96.7058;587.034 37.9425;49.4216;13.8374;101.065;185.143;124.212;496.452;280.185;1362.21 8 24567;24539;24404;24890;117517;24207;25748;114628 MT1A_9255;LPL_32544;GPX1_33050;ESR1_33192;C7_8179;APOC3_32553;ALAS2_8019;ABCG5_7947 317.07476625 114.682 382.09849952588996 192.58023624999998 59.26105 236.30095102653334 760.0148262499999 265.2715 1155.9664366461132 818.334;900.118;8.00432;12.5403;103.858;2.87451;125.506;565.363 540.216;487.466;2.69961;3.74981;32.7314;1.13737;85.7907;386.851 988.495;3428.38;25.2254;51.2968;293.781;8.23841;236.762;1047.94 0 Exp 2,2(0.12);Exp 4,3(0.18);Exp 5,1(0.06);Hill,7(0.42);Linear,1(0.06);Poly 2,3(0.18) 1.7882890521625876 30.59677290916443 1.5235437154769897 2.3371741771698 0.21641132252085735 1.7603585720062256 75.03962336340354 376.9598860483612 39.49282868220942 240.56088308249642 106.4413135689386 920.6865817251789 CONFLICT 0.5294117647058824 0.47058823529411764 0.0 GO:0031297 7 replication fork processing 3 3 1 1 1 1 1 1 68 2 2476 0.99787 0.07912 0.07912 33.33 313108 mms22l MMS22L_33129 4.13516 4.13516 4.13516 4.13516 1.24709 1.24709 1.24709 1.24709 20.8956 20.8956 20.8956 20.895599999999998 0.0 4.13516 0.0 4.13516 4.13516 1.24709 20.8956 1 0 1 313108 MMS22L_33129 4.13516 4.13516 1.24709 1.24709 20.8956 20.8956 4.13516 1.24709 20.8956 0 0 Exp 4,1(1) 1.65592360496521 1.65592360496521 1.65592360496521 1.65592360496521 0.0 1.65592360496521 4.13516 4.13516 1.24709 1.24709 20.8956 20.8956 UP 1.0 0.0 0.0 GO:0032501 2 multicellular organismal process 609 640 33 33 29 19 15 15 54 625 1853 0.30845 0.78531 0.57544 2.34 192247;259241;316351;24539;288001;29200;360504;24404;29739;25283;84586;24890;310395;24207;114628 sez6;nr1d2;npas2;lpl;kng1;inhba;hba-a2;gpx1;gclm;gclc;fgl2;esr1;noct;apoc3;abcg5 SEZ6_9819;NR1D2_9358;NPAS2_9350;LPL_32544;KNG1L1_32433;INHBA_33300;HBA2_32600;GPX1_33050;GCLM_8700;GCLC_8699;FGL2_32918;ESR1_33192;CCRN4L_8232;APOC3_32553;ABCG5_7947 288001(0.1788) 195.77400666666665 91.8104 2.87451 280.9822972160262 198.95997533525545 281.1855152214286 115.44660466666667 44.1594 1.13737 170.87555976569277 121.99514099551222 177.9271626920291 522.4860206666666 215.15 8.23841 901.2851770300728 482.6728267404574 802.1079059805103 10.6392;9.46041;53.0014;900.118;3.87556;91.8104;131.05;8.00432;190.233;145.958;146.406;12.5403;665.276;2.87451;565.363 3.96047;2.2133;14.3825;487.466;1.25511;44.1594;88.5948;2.69961;69.2223;96.7058;95.6156;3.74981;433.686;1.13737;386.851 29.4997;49.4216;215.15;3428.38;13.8374;186.93;254.163;25.2254;496.452;280.185;325.091;51.2968;1425.48;8.23841;1047.94 5 10 5 259241;288001;29739;25283;310395 NR1D2_9358;KNG1L1_32433;GCLM_8700;GCLC_8699;CCRN4L_8232 202.960594 145.958 271.21209134527794 120.616502 69.2223 179.92502354547022 453.07520000000005 280.185 577.323509143513 9.46041;3.87556;190.233;145.958;665.276 2.2133;1.25511;69.2223;96.7058;433.686 49.4216;13.8374;496.452;280.185;1425.48 10 192247;316351;24539;29200;360504;24404;84586;24890;24207;114628 SEZ6_9819;NPAS2_9350;LPL_32544;INHBA_33300;HBA2_32600;GPX1_33050;FGL2_32918;ESR1_33192;APOC3_32553;ABCG5_7947 192.18071300000003 72.4059 300.130225834344 112.861656 29.27095 176.09526518138247 557.191431 201.04000000000002 1054.254127209614 10.6392;53.0014;900.118;91.8104;131.05;8.00432;146.406;12.5403;2.87451;565.363 3.96047;14.3825;487.466;44.1594;88.5948;2.69961;95.6156;3.74981;1.13737;386.851 29.4997;215.15;3428.38;186.93;254.163;25.2254;325.091;51.2968;8.23841;1047.94 0 Exp 2,1(0.07);Exp 4,2(0.14);Hill,7(0.47);Linear,2(0.14);Poly 2,3(0.2) 1.9431447661410737 29.99543070793152 1.5235437154769897 3.747737169265747 0.5660710286063304 1.783576488494873 53.57734499428847 337.97066833904483 28.971640226470655 201.9215691068627 66.3727898393795 978.5992514939537 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0048871 4 multicellular organismal homeostasis 34 36 4 4 4 2 2 2 67 34 2444 0.92807 0.25485 0.25485 5.56 259241;24404 nr1d2;gpx1 NR1D2_9358;GPX1_33050 8.732365 8.732365 8.00432 1.0296111130179295 8.906252092964024 0.9998127834004704 2.456455 2.456455 2.2133 0.3438730987588252 2.3983795842088504 0.33392094904538433 37.323499999999996 37.323499999999996 25.2254 17.109297098945955 40.21302391595033 16.61413104252831 0.5 8.732365 9.46041;8.00432 2.2133;2.69961 49.4216;25.2254 1 1 1 259241 NR1D2_9358 9.46041 9.46041 2.2133 2.2133 49.4216 49.4216 9.46041 2.2133 49.4216 1 24404 GPX1_33050 8.00432 8.00432 2.69961 2.69961 25.2254 25.2254 8.00432 2.69961 25.2254 0 Hill,2(1) 1.971081736562263 3.9616416692733765 1.7846373319625854 2.177004337310791 0.2774453701955745 1.9808208346366882 7.3053968000000005 10.159333199999999 1.9798712 2.9330388000000003 13.611223999999996 61.035776 CONFLICT 0.5 0.5 0.0 GO:0005975 4 carbohydrate metabolic process 100 118 5 5 5 3 3 3 66 115 2363 0.60178 0.62872 1.0 2.54 83472;361042;25283 ugdh;pck2;gclc UGDH_10131;PCK2_9440;GCLC_8699 70.66727666666667 59.3662 6.67763 70.32454135793304 54.698174896640126 71.77396541917304 41.20981666666666 25.4417 1.48195 49.5315104717778 31.806391645745418 49.19217107320745 151.06516666666667 135.068 37.9425 121.91098887132091 122.60211073126436 124.97334561469319 59.3662;6.67763;145.958 25.4417;1.48195;96.7058 135.068;37.9425;280.185 3 0 3 83472;361042;25283 UGDH_10131;PCK2_9440;GCLC_8699 70.66727666666667 59.3662 70.32454135793304 41.20981666666666 25.4417 49.5315104717778 151.06516666666667 135.068 121.91098887132091 59.3662;6.67763;145.958 25.4417;1.48195;96.7058 135.068;37.9425;280.185 0 0 Hill,2(0.67);Poly 2,1(0.34) 1.61800462207899 4.863090634346008 1.528982162475586 1.7603585720062256 0.12272054277693764 1.5737498998641968 -8.912433385266965 150.24698671860028 -14.840363905662699 97.25999723899604 13.109895872286671 289.02043746104664 UP 1.0 0.0 0.0 GO:0080090 5 regulation of primary metabolic process 955 1029 50 50 42 27 20 20 49 1009 1469 0.031522 0.98295 0.061393 1.94 360243;299270;94195;363465;259241;316351;288001;64194;29200;24426;24404;25283;25317;24890;298452;24309;25426;289185;310395;24207 top2a;serpina6;s100a9;pir;nr1d2;npas2;kng1;insig1;inhba;gstp1;gpx1;gclc;fgf1;esr1;dph2;dbp;cyp1b1;creg1;noct;apoc3 TOP2A_10059;SERPINA6_32325;S100A9_9775;PIR_9487;NR1D2_9358;NPAS2_9350;KNG1L1_32433;INSIG1_8906;INHBA_33300;GSTP1_8762;GPX1_33050;GCLC_8699;FGF1_8633;ESR1_33192;DPH2_8490;DBP_8439;CYP1B1_32710;CREG1_8380;CCRN4L_8232;APOC3_32553 288001(0.1788) 204.7799400000002 78.92405 4.48597E-12 296.0216339903137 187.5291316536823 274.0230576326188 135.39207100000021 28.3611 4.48597E-12 221.157990631905 121.1644708699073 190.0338185242098 414.9411305000002 215.8615 4.48599E-12 553.0510368563923 402.46198107687746 570.8657055633196 4.48597E-12;25.7745;963.318;152.213;9.46041;53.0014;3.87556;37.6554;91.8104;122.514;8.00432;145.958;674.162;12.5403;734.134;66.0377;229.313;97.6763;665.276;2.87451 4.48597E-12;8.17372;802.143;56.4566;2.2133;14.3825;1.25511;13.2791;44.1594;84.8469;2.69961;96.7058;437.622;3.74981;463.289;19.9899;185.32;36.7323;433.686;1.13737 4.48599E-12;103.274;1158.68;371.778;49.4216;215.15;13.8374;101.065;186.93;216.573;25.2254;280.185;1465.0;51.2968;1764.85;280.428;299.27;282.14;1425.48;8.23841 13 7 13 360243;94195;363465;259241;288001;64194;24426;25283;25317;24309;25426;289185;310395 TOP2A_10059;S100A9_9775;PIR_9487;NR1D2_9358;KNG1L1_32433;INSIG1_8906;GSTP1_8762;GCLC_8699;FGF1_8633;DBP_8439;CYP1B1_32710;CREG1_8380;CCRN4L_8232 243.6507207692311 122.514 313.68842320167875 166.9423084615388 56.4566 244.3932848330473 457.21984615384645 280.428 526.5760146465093 4.48597E-12;963.318;152.213;9.46041;3.87556;37.6554;122.514;145.958;674.162;66.0377;229.313;97.6763;665.276 4.48597E-12;802.143;56.4566;2.2133;1.25511;13.2791;84.8469;96.7058;437.622;19.9899;185.32;36.7323;433.686 4.48599E-12;1158.68;371.778;49.4216;13.8374;101.065;216.573;280.185;1465.0;280.428;299.27;282.14;1425.48 7 299270;316351;29200;24404;24890;298452;24207 SERPINA6_32325;NPAS2_9350;INHBA_33300;GPX1_33050;ESR1_33192;DPH2_8490;APOC3_32553 132.59134714285713 25.7745 267.08977469094515 76.79877285714285 8.17372 171.0734238698949 336.4235157142857 103.274 634.778631938175 25.7745;53.0014;91.8104;8.00432;12.5403;734.134;2.87451 8.17372;14.3825;44.1594;2.69961;3.74981;463.289;1.13737 103.274;215.15;186.93;25.2254;51.2968;1764.85;8.23841 0 Exp 4,4(0.2);Exp 5,1(0.05);Hill,8(0.4);Linear,4(0.2);Poly 2,3(0.15) 2.006368268342878 42.34428632259369 1.5235437154769897 5.5128583908081055 0.896868202887284 1.7724979519844055 75.04273870307108 334.51714129692937 38.465308039240796 232.31883396075963 172.55582666622374 657.3264343337767 UP 0.65 0.35 0.0 GO:0006955 3 immune response 185 212 8 8 4 8 4 4 65 208 2270 0.30644 0.83997 0.65625 1.89 94195;24614;170496;117517 s100a9;orm1;lcn2;c7 S100A9_9775;ORM1_9400;LCN2_32481;C7_8179 675.573 812.904 103.858 407.45833159068764 462.35489298096047 461.9147107969176 454.81260000000003 492.188 32.7314 320.7923727823133 280.67998150610975 327.00247717713904 1737.5877500000001 1286.0 293.781 1636.3768280218699 1404.4766413185566 1768.1504029739322 963.318;662.49;972.626;103.858 802.143;432.445;551.931;32.7314 1158.68;1413.32;4084.57;293.781 3 1 3 94195;24614;170496 S100A9_9775;ORM1_9400;LCN2_32481 866.1446666666667 963.318 176.4315084029303 595.5063333333334 551.931 188.66176098333597 2218.8566666666666 1413.32 1620.7637286271352 963.318;662.49;972.626 802.143;432.445;551.931 1158.68;1413.32;4084.57 1 117517 C7_8179 103.858 103.858 32.7314 32.7314 293.781 293.781 103.858 32.7314 293.781 0 Hill,1(0.25);Linear,2(0.5);Poly 2,1(0.25) 1.754309233757219 7.042213320732117 1.5487829446792603 1.9308089017868042 0.16946030011447705 1.7813107371330261 276.2638350411264 1074.8821649588738 140.436074673333 769.1891253266671 133.93845853856715 3341.2370414614325 UP 0.75 0.25 0.0 GO:0051716 3 cellular response to stimulus 785 838 58 58 47 39 29 29 40 809 1669 0.95925 0.067908 0.11854 3.46 360243;287877;361042;24614;338475;24567;313108;29685;312538;59107;24539;170496;293502;64194;29200;25663;24426;300850;116686;24404;29739;25283;25317;24890;25315;25426;24296;25612;24207 top2a;pycr1;pck2;orm1;nrep;mt1;mms22l;mcm6;mcm2;ltbp1;lpl;lcn2;kif22;insig1;inhba;il1r1;gstp1;gsta4;gsr;gpx1;gclm;gclc;fgf1;esr1;ephx1;cyp1b1;cyp1a1;asns;apoc3 TOP2A_10059;PYCR1_9631;PCK2_9440;ORM1_9400;NREP_9364;MT1A_9255;MMS22L_33129;MCM6_9210;MCM2_9206;LTBP1_33264;LPL_32544;LCN2_32481;KIF22_8963;INSIG1_8906;INHBA_33300;IL1R1_8893;GSTP1_8762;GSTA4_8757;GSR_8755;GPX1_33050;GCLM_8700;GCLC_8699;FGF1_8633;ESR1_33192;EPHX1_8567;CYP1B1_32710;CYP1A1_8415;ASNS_8091;APOC3_32553 226.9520515862071 83.0393 4.48597E-12 312.85406647667827 159.461415417635 256.77326672513647 138.16124348275878 44.1594 4.48597E-12 189.41647990231306 99.02274031069263 156.91373621477555 587.3274131034484 185.143 4.48599E-12 1026.7855236058294 403.8229868889864 852.3361134551255 4.48597E-12;132.668;6.67763;662.49;191.159;818.334;4.13516;1.87441;3.76863;769.394;900.118;972.626;0.961856;37.6554;91.8104;76.6218;122.514;339.498;69.5519;8.00432;190.233;145.958;674.162;12.5403;27.5708;229.313;83.0393;6.05608;2.87451 4.48597E-12;90.3184;1.48195;432.445;115.886;540.216;1.24709;0.496857;0.956203;438.027;487.466;551.931;0.281971;13.2791;44.1594;27.5215;84.8469;260.156;41.1016;2.69961;69.2223;96.7058;437.622;3.74981;12.6303;185.32;63.0271;2.7438;1.13737 4.48599E-12;239.858;37.9425;1413.32;448.068;988.495;20.8956;9.53;22.9217;2211.2;3428.38;4084.57;4.47267;101.065;186.93;185.143;216.573;486.944;124.212;25.2254;496.452;280.185;1465.0;51.2968;61.9858;299.27;119.986;14.3351;8.23841 21 8 21 360243;287877;361042;24614;313108;29685;312538;170496;293502;64194;25663;24426;300850;116686;29739;25283;25317;25315;25426;24296;25612 TOP2A_10059;PYCR1_9631;PCK2_9440;ORM1_9400;MMS22L_33129;MCM6_9210;MCM2_9206;LCN2_32481;KIF22_8963;INSIG1_8906;IL1R1_8893;GSTP1_8762;GSTA4_8757;GSR_8755;GCLM_8700;GCLC_8699;FGF1_8633;EPHX1_8567;CYP1B1_32710;CYP1A1_8415;ASNS_8091 180.3511888571431 76.6218 267.7850157292932 113.01594623809545 41.1016 166.31554346327607 461.1743509523812 124.212 927.309322032722 4.48597E-12;132.668;6.67763;662.49;4.13516;1.87441;3.76863;972.626;0.961856;37.6554;76.6218;122.514;339.498;69.5519;190.233;145.958;674.162;27.5708;229.313;83.0393;6.05608 4.48597E-12;90.3184;1.48195;432.445;1.24709;0.496857;0.956203;551.931;0.281971;13.2791;27.5215;84.8469;260.156;41.1016;69.2223;96.7058;437.622;12.6303;185.32;63.0271;2.7438 4.48599E-12;239.858;37.9425;1413.32;20.8956;9.53;22.9217;4084.57;4.47267;101.065;185.143;216.573;486.944;124.212;496.452;280.185;1465.0;61.9858;299.27;119.986;14.3351 8 338475;24567;59107;24539;29200;24404;24890;24207 NREP_9364;MT1A_9255;LTBP1_33264;LPL_32544;INHBA_33300;GPX1_33050;ESR1_33192;APOC3_32553 349.27931624999997 141.4847 403.7471370150793 204.16764875 80.0227 240.0151514134764 918.47920125 317.499 1259.8485280729483 191.159;818.334;769.394;900.118;91.8104;8.00432;12.5403;2.87451 115.886;540.216;438.027;487.466;44.1594;2.69961;3.74981;1.13737 448.068;988.495;2211.2;3428.38;186.93;25.2254;51.2968;8.23841 0 Exp 2,2(0.07);Exp 4,4(0.14);Exp 5,1(0.04);Hill,11(0.38);Linear,5(0.18);Poly 2,6(0.21) 2.0628198382932013 64.80562460422516 1.5140434503555298 6.292444229125977 1.1409306221995728 1.7846373319625854 113.08478990427992 340.81931326813424 69.22067919089594 207.10180777462168 213.6156144225281 961.0392117843685 UP 0.7241379310344828 0.27586206896551724 0.0 GO:0033043 6 regulation of organelle organization 271 282 17 17 16 6 6 6 63 276 2202 0.34353 0.79323 0.69667 2.13 360243;312538;287598;64194;24404;25283 top2a;mcm2;ska2;insig1;gpx1;gclc TOP2A_10059;MCM2_9206;LOC691962_32591;INSIG1_8906;GPX1_33050;GCLC_8699 32.97657833333408 5.886475 4.48597E-12 57.063695349997424 31.560949966804955 55.41425337282588 19.075201000000746 1.8279064999999999 4.48597E-12 38.35107719097283 18.039610082648966 37.19046528403559 73.29681666666743 24.07355 4.48599E-12 107.47351012011069 70.53651070021482 104.75753111413675 4.48597E-12;3.76863;2.47312;37.6554;8.00432;145.958 4.48597E-12;0.956203;0.810493;13.2791;2.69961;96.7058 4.48599E-12;22.9217;10.3838;101.065;25.2254;280.185 5 1 5 360243;312538;287598;64194;25283 TOP2A_10059;MCM2_9206;LOC691962_32591;INSIG1_8906;GCLC_8699 37.971030000000894 3.76863 62.315708716716166 22.350319200000897 0.956203 41.92920709905153 82.9111000000009 22.9217 117.23879857717672 4.48597E-12;3.76863;2.47312;37.6554;145.958 4.48597E-12;0.956203;0.810493;13.2791;96.7058 4.48599E-12;22.9217;10.3838;101.065;280.185 1 24404 GPX1_33050 8.00432 8.00432 2.69961 2.69961 25.2254 25.2254 8.00432 2.69961 25.2254 0 Exp 4,1(0.17);Exp 5,1(0.17);Hill,3(0.5);Poly 2,1(0.17) 1.7086183718565144 10.296056985855103 1.503517508506775 1.9665359258651733 0.17394680557507175 1.7566587328910828 -12.683887572072706 78.63704423874087 -11.612051933297373 49.762453933298865 -12.699901815636906 159.29353514897173 UP 0.8333333333333334 0.16666666666666666 0.0 GO:0050776 5 regulation of immune response 176 199 7 7 6 5 4 4 65 195 2283 0.36263 0.80096 0.65401 2.01 25663;24404;84586;117517 il1r1;gpx1;fgl2;c7 IL1R1_8893;GPX1_33050;FGL2_32918;C7_8179 83.72253 90.2399 8.00432 58.07558940868589 73.10836069584842 50.23780912242403 39.6420275 30.12645 2.69961 39.54932358662652 26.3758609652546 23.727758910142704 207.3101 239.462 25.2254 135.39543966731915 195.9905998307396 133.44081809666767 76.6218;8.00432;146.406;103.858 27.5215;2.69961;95.6156;32.7314 185.143;25.2254;325.091;293.781 1 3 1 25663 IL1R1_8893 76.6218 76.6218 27.5215 27.5215 185.143 185.143 76.6218 27.5215 185.143 3 24404;84586;117517 GPX1_33050;FGL2_32918;C7_8179 86.08944000000001 103.858 70.89109640893417 43.68220333333333 32.7314 47.41608766709918 214.69913333333332 293.781 164.83416133330297 8.00432;146.406;103.858 2.69961;95.6156;32.7314 25.2254;325.091;293.781 0 Hill,3(0.75);Poly 2,1(0.25) 1.763932467296764 7.067966103553772 1.6593536138534546 1.9308089017868042 0.12135841916520132 1.7389017939567566 26.808452379487846 140.63660762051217 0.8836903851060214 78.40036461489397 74.6225691260272 339.9976308739728 DOWN 0.25 0.75 0.0 GO:1903506 8 regulation of nucleic acid-templated transcription 474 508 24 24 19 16 12 12 57 496 1982 0.35947 0.75019 0.75971 2.36 360243;363465;259241;316351;64194;29200;25283;25317;24890;24309;25426;289185 top2a;pir;nr1d2;npas2;insig1;inhba;gclc;fgf1;esr1;dbp;cyp1b1;creg1 TOP2A_10059;PIR_9487;NR1D2_9358;NPAS2_9350;INSIG1_8906;INHBA_33300;GCLC_8699;FGF1_8633;ESR1_33192;DBP_8439;CYP1B1_32710;CREG1_8380 130.81899250000038 78.92405 4.48597E-12 184.14241196943598 149.48313685095914 210.2981569178935 75.8842258333337 28.3611 4.48597E-12 125.55185422980108 93.59979558502731 143.19304909175017 298.555366666667 247.66750000000002 4.48599E-12 385.84612400060405 324.4439190894481 441.0863475085188 4.48597E-12;152.213;9.46041;53.0014;37.6554;91.8104;145.958;674.162;12.5403;66.0377;229.313;97.6763 4.48597E-12;56.4566;2.2133;14.3825;13.2791;44.1594;96.7058;437.622;3.74981;19.9899;185.32;36.7323 4.48599E-12;371.778;49.4216;215.15;101.065;186.93;280.185;1465.0;51.2968;280.428;299.27;282.14 9 3 9 360243;363465;259241;64194;25283;25317;24309;25426;289185 TOP2A_10059;PIR_9487;NR1D2_9358;INSIG1_8906;GCLC_8699;FGF1_8633;DBP_8439;CYP1B1_32710;CREG1_8380 156.94175666666717 97.6763 207.7510590782072 94.25766666666716 36.7323 141.5827489276144 347.6986222222227 280.428 438.0868254278301 4.48597E-12;152.213;9.46041;37.6554;145.958;674.162;66.0377;229.313;97.6763 4.48597E-12;56.4566;2.2133;13.2791;96.7058;437.622;19.9899;185.32;36.7323 4.48599E-12;371.778;49.4216;101.065;280.185;1465.0;280.428;299.27;282.14 3 316351;29200;24890 NPAS2_9350;INHBA_33300;ESR1_33192 52.450700000000005 53.0014 39.637919236130436 20.76390333333333 14.3825 20.94696809490656 151.1256 186.93 87.59813971814702 53.0014;91.8104;12.5403 14.3825;44.1594;3.74981 215.15;186.93;51.2968 0 Exp 4,2(0.17);Exp 5,1(0.09);Hill,6(0.5);Linear,2(0.17);Poly 2,1(0.09) 2.020864373298029 24.780306935310364 1.5704141855239868 3.1843981742858887 0.4736743495466332 1.934571921825409 26.63061480261517 235.00737019738557 4.84657693323804 146.92187473342938 80.24237038029509 516.868362953039 UP 0.75 0.25 0.0 GO:0071356 7 cellular response to tumor necrosis factor 67 70 5 5 4 4 3 3 66 67 2411 0.88064 0.29437 0.43673 4.29 361042;170496;25426 pck2;lcn2;cyp1b1 PCK2_9440;LCN2_32481;CYP1B1_32710 402.87221 229.313 6.67763 505.82226414846775 264.9240599924708 413.13901100569797 246.2443166666667 185.32 1.48195 280.23627251383937 172.38801056594303 234.87126194203668 1473.9275 299.27 37.9425 2264.655318733681 840.0007600284436 1812.478356280606 6.67763;972.626;229.313 1.48195;551.931;185.32 37.9425;4084.57;299.27 3 0 3 361042;170496;25426 PCK2_9440;LCN2_32481;CYP1B1_32710 402.87221 229.313 505.82226414846775 246.2443166666667 185.32 280.23627251383937 1473.9275 299.27 2264.655318733681 6.67763;972.626;229.313 1.48195;551.931;185.32 37.9425;4084.57;299.27 0 0 Hill,1(0.34);Linear,2(0.67) 2.0832746191465965 6.5703712701797485 1.528982162475586 3.1843981742858887 0.8765464343168055 1.856990933418274 -169.5195659217187 975.2639859217187 -70.87287858355577 563.3615119168891 -1088.7712414695125 4036.626241469512 UP 1.0 0.0 0.0 GO:0051049 5 regulation of transport 454 483 23 23 19 14 10 10 59 473 2005 0.21367 0.86996 0.43571 2.07 94195;361042;24614;24539;64194;29200;25283;24890;24207;114628 s100a9;pck2;orm1;lpl;insig1;inhba;gclc;esr1;apoc3;abcg5 S100A9_9775;PCK2_9440;ORM1_9400;LPL_32544;INSIG1_8906;INHBA_33300;GCLC_8699;ESR1_33192;APOC3_32553;ABCG5_7947 338.880524 118.88419999999999 2.87451 391.533046510398 231.61344400571147 330.09223407774886 226.941843 70.4326 1.13737 281.6989757621105 149.9361001759606 223.53492843017202 771.397771 233.5575 8.23841 1073.3765354404936 540.375664831307 915.3409520668808 963.318;6.67763;662.49;900.118;37.6554;91.8104;145.958;12.5403;2.87451;565.363 802.143;1.48195;432.445;487.466;13.2791;44.1594;96.7058;3.74981;1.13737;386.851 1158.68;37.9425;1413.32;3428.38;101.065;186.93;280.185;51.2968;8.23841;1047.94 5 5 5 94195;361042;24614;64194;25283 S100A9_9775;PCK2_9440;ORM1_9400;INSIG1_8906;GCLC_8699 363.21980599999995 145.958 427.19951121407803 269.21097 96.7058 345.54300783641537 598.2385 280.185 640.4536775101303 963.318;6.67763;662.49;37.6554;145.958 802.143;1.48195;432.445;13.2791;96.7058 1158.68;37.9425;1413.32;101.065;280.185 5 24539;29200;24890;24207;114628 LPL_32544;INHBA_33300;ESR1_33192;APOC3_32553;ABCG5_7947 314.54124200000007 91.8104 401.17372875678103 184.67271599999998 44.1594 233.83869679590552 944.557042 186.93 1451.6085644923894 900.118;91.8104;12.5403;2.87451;565.363 487.466;44.1594;3.74981;1.13737;386.851 3428.38;186.93;51.2968;8.23841;1047.94 0 Exp 2,1(0.1);Exp 4,1(0.1);Exp 5,1(0.1);Hill,3(0.3);Linear,2(0.2);Poly 2,2(0.2) 1.7417790166580274 17.545419692993164 1.5235437154769897 2.2924909591674805 0.23268424979126776 1.718746304512024 96.20582758529034 581.5552204147098 52.3430089228122 401.54067707718775 106.11210176140844 1436.6834402385914 CONFLICT 0.5 0.5 0.0 GO:0006694 6 steroid biosynthetic process 45 49 12 12 11 3 2 2 67 47 2431 0.85455 0.38548 0.38548 4.08 64194;24296 insig1;cyp1a1 INSIG1_8906;CYP1A1_8415 60.34735 60.34735 37.6554 32.09126344669217 66.30195401407062 30.96666872100111 38.153099999999995 38.153099999999995 13.2791 35.17714815046837 44.68029665987244 33.9444127880672 110.5255 110.5255 101.065 13.379167406830845 113.00803373002827 12.91031266308223 37.6554;83.0393 13.2791;63.0271 101.065;119.986 2 0 2 64194;24296 INSIG1_8906;CYP1A1_8415 60.34735 60.34735 32.09126344669217 38.153099999999995 38.153099999999995 35.17714815046837 110.5255 110.5255 13.379167406830845 37.6554;83.0393 13.2791;63.0271 101.065;119.986 0 0 Exp 5,1(0.5);Poly 2,1(0.5) 3.5177148318303484 8.25898015499115 1.9665359258651733 6.292444229125977 3.0588790960269057 4.129490077495575 15.871128000000006 104.82357199999998 -10.599940000000004 86.90614 91.98291999999998 129.06808 UP 1.0 0.0 0.0 GO:0042060 5 wound healing 52 55 3 3 3 2 2 2 67 53 2425 0.81464 0.4428 0.65998 3.64 59107;25317 ltbp1;fgf1 LTBP1_33264;FGF1_8633 721.778 721.778 674.162 67.33919298595693 690.8071060256142 51.148551933114526 437.8245 437.8245 437.622 0.28637824643616216 437.6927878437959 0.21752313867584383 1838.1 1838.1 1465.0 527.6430801214016 1595.4244173840018 400.7796691499847 769.394;674.162 438.027;437.622 2211.2;1465.0 1 1 1 25317 FGF1_8633 674.162 674.162 437.622 437.622 1465.0 1465.0 674.162 437.622 1465.0 1 59107 LTBP1_33264 769.394 769.394 438.027 438.027 2211.2 2211.2 769.394 438.027 2211.2 0 Exp 2,1(0.5);Linear,1(0.5) 1.5419712422538905 3.0844576358795166 1.5140434503555298 1.5704141855239868 0.03986012909808696 1.5422288179397583 628.45064 815.10536 437.42760000000004 438.22139999999996 1106.824 2569.3759999999997 CONFLICT 0.5 0.5 0.0 GO:0055085 4 transmembrane transport 188 198 8 7 5 6 3 3 66 195 2283 0.20233 0.9147 0.36551 1.52 266730;301111;114628 slc17a3;ano10;abcg5 SLC17A3_9840;ANO10_8049;ABCG5_7947 222.8892 93.3839 9.9207 299.5125276234536 289.70258818634846 309.4442026802946 152.89756666666668 68.9252 2.9165 205.2801594048079 199.11359912220547 211.2632449142109 408.1821 143.418 33.1883 556.7811730382324 530.0771274082201 579.2520624671268 93.3839;9.9207;565.363 68.9252;2.9165;386.851 143.418;33.1883;1047.94 2 1 2 266730;301111 SLC17A3_9840;ANO10_8049 51.6523 51.6523 59.01739469952906 35.92085 35.92085 46.67519938730846 88.30315 88.30315 77.94416835815879 93.3839;9.9207 68.9252;2.9165 143.418;33.1883 1 114628 ABCG5_7947 565.363 565.363 386.851 386.851 1047.94 1047.94 565.363 386.851 1047.94 0 Hill,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 1.6168121969435303 4.863135576248169 1.504341721534729 1.783576488494873 0.1451487374640167 1.575217366218567 -116.04113136016957 561.8195313601695 -79.39880170497736 385.1939350383107 -221.87510986134458 1038.2393098613447 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0043412 5 macromolecule modification 438 472 19 18 15 12 9 9 60 463 2015 0.15007 0.91603 0.27349 1.91 171497;94195;24404;499709;171142;298452;25426;81508;360887 sgk2;s100a9;gpx1;gar1;ehhadh;dph2;cyp1b1;bhmt;coq8a SGK2_32380;S100A9_9775;GPX1_33050;GAR1_8683;EHHADH_8534;DPH2_8490;CYP1B1_32710;BHMT_8143;ADCK3_7987 499709(-0.07184) 394.8904355555556 229.313 5.5396 358.8099972996703 275.0538540500105 292.46673781093676 287.1958466666667 185.32 1.97501 280.4207351314718 193.09250898676189 213.02328488985094 712.6722555555557 384.658 25.2254 630.1596964464624 532.8339792330321 590.7895310950506 156.37;963.318;8.00432;765.364;166.899;734.134;229.313;5.5396;525.072 100.616;802.143;2.69961;587.034;105.26;463.289;185.32;1.97501;336.426 343.205;1158.68;25.2254;1362.21;384.658;1764.85;299.27;37.8319;1038.12 4 5 4 171497;94195;499709;25426 SGK2_32380;S100A9_9775;GAR1_8683;CYP1B1_32710 528.59125 497.3385 397.1417933948992 418.77825 386.177 332.1688831346438 790.84125 750.9425 548.8740294514309 156.37;963.318;765.364;229.313 100.616;802.143;587.034;185.32 343.205;1158.68;1362.21;299.27 5 24404;171142;298452;81508;360887 GPX1_33050;EHHADH_8534;DPH2_8490;BHMT_8143;ADCK3_7987 287.92978400000004 166.899 327.14124055077076 181.92992399999997 105.26 208.21714682178754 650.13706 384.658 746.4963200511359 8.00432;166.899;734.134;5.5396;525.072 2.69961;105.26;463.289;1.97501;336.426 25.2254;384.658;1764.85;37.8319;1038.12 0 Exp 2,2(0.23);Exp 4,1(0.12);Hill,1(0.12);Linear,2(0.23);Poly 2,3(0.34) 1.802229067073227 16.64225661754608 1.5039241313934326 3.1843981742858887 0.5134435880227395 1.6845101118087769 160.46790398643768 629.3129671246735 103.98763304743838 470.40406028589484 300.9679205438668 1124.3765905672444 CONFLICT 0.4444444444444444 0.5555555555555556 0.0 GO:0071222 6 cellular response to lipopolysaccharide 81 86 4 4 3 3 2 2 67 84 2394 0.58558 0.68522 1.0 2.33 170496;24426 lcn2;gstp1 LCN2_32481;GSTP1_8762 547.5699999999999 547.5699999999999 122.514 601.1199599680584 761.5023700440528 519.4334301589271 318.38895 318.38895 84.8469 330.2783344944156 435.93158970264324 285.3966256630835 2150.5715 2150.5715 216.573 2735.0869083092225 3123.960612885463 2363.414408400821 972.626;122.514 551.931;84.8469 4084.57;216.573 2 0 2 170496;24426 LCN2_32481;GSTP1_8762 547.5699999999999 547.5699999999999 601.1199599680584 318.38895 318.38895 330.2783344944156 2150.5715 2150.5715 2735.0869083092225 972.626;122.514 551.931;84.8469 4084.57;216.573 0 0 Linear,1(0.5);Poly 2,1(0.5) 3.199582480410453 7.369849324226379 1.856990933418274 5.5128583908081055 2.5850886702395717 3.6849246621131897 -285.53976 1380.67976 -139.35346800000002 776.1313680000001 -1640.06556 5941.20856 UP 1.0 0.0 0.0 GO:0090501 7 RNA phosphodiester bond hydrolysis 18 22 3 3 3 2 2 2 67 20 2458 0.97973 0.1181 0.1181 9.09 291317;310395 rpp38;noct RPP38_9741;CCRN4L_8232 791.1189999999999 791.1189999999999 665.276 177.96887732971814 788.7790894581439 177.93810984528298 601.799 601.799 433.686 237.7476846112282 598.6731258478973 237.70658249104127 1238.6 1238.6 1051.72 264.28823053628525 1242.0748256324318 264.24254005297536 0.5 791.1189999999999 916.962;665.276 769.912;433.686 1051.72;1425.48 1 1 1 310395 CCRN4L_8232 665.276 665.276 433.686 433.686 1425.48 1425.48 665.276 433.686 1425.48 1 291317 RPP38_9741 916.962 916.962 769.912 769.912 1051.72 1051.72 916.962 769.912 1051.72 0 Linear,1(0.5);Poly 2,1(0.5) 1.673934470973786 3.3518433570861816 1.5943320989608765 1.7575112581253052 0.1153850899934865 1.6759216785430908 544.4667199999999 1037.77128 272.29751999999996 931.30048 872.3151999999999 1604.8847999999998 CONFLICT 0.5 0.5 0.0 GO:0034516 6 response to vitamin B6 1 1 1 1 1 1 1 1 68 0 2478 1.0 0.027091 0.027091 100.0 116682 kynu KYNU_8979 100.381 100.381 100.381 100.381 72.7231 72.7231 72.7231 72.72309999999999 161.456 161.456 161.456 161.456 0.0 100.381 0.0 100.381 100.381 72.7231 161.456 0 1 0 1 116682 KYNU_8979 100.381 100.381 72.7231 72.7231 161.456 161.456 100.381 72.7231 161.456 0 Poly 2,1(1) 1.957481861114502 1.957481861114502 1.957481861114502 1.957481861114502 0.0 1.957481861114502 100.381 100.381 72.7231 72.7231 161.456 161.456 DOWN 0.0 1.0 0.0 GO:0097053 6 L-kynurenine catabolic process 1 1 1 1 1 1 1 1 68 0 2478 1.0 0.027091 0.027091 100.0 116682 kynu KYNU_8979 100.381 100.381 100.381 100.381 72.7231 72.7231 72.7231 72.72309999999999 161.456 161.456 161.456 161.456 0.0 100.381 0.0 100.381 100.381 72.7231 161.456 0 1 0 1 116682 KYNU_8979 100.381 100.381 72.7231 72.7231 161.456 161.456 100.381 72.7231 161.456 0 Poly 2,1(1) 1.957481861114502 1.957481861114502 1.957481861114502 1.957481861114502 0.0 1.957481861114502 100.381 100.381 72.7231 72.7231 161.456 161.456 DOWN 0.0 1.0 0.0 GO:0043401 6 steroid hormone mediated signaling pathway 34 37 3 3 2 3 2 2 67 35 2443 0.92319 0.26502 0.26502 5.41 259241;24890 nr1d2;esr1 NR1D2_9358;ESR1_33192 11.000354999999999 11.000354999999999 9.46041 2.1778111043086446 10.686037720014854 2.1319640008816845 2.981555 2.981555 2.2133 1.086476640360941 2.824746917935388 1.0636042219023176 50.3592 50.3592 49.4216 1.3259666360811344 50.1678270082931 1.298052493580706 0.5 11.000354999999999 9.46041;12.5403 2.2133;3.74981 49.4216;51.2968 1 1 1 259241 NR1D2_9358 9.46041 9.46041 2.2133 2.2133 49.4216 49.4216 9.46041 2.2133 49.4216 1 24890 ESR1_33192 12.5403 12.5403 3.74981 3.74981 51.2968 51.2968 12.5403 3.74981 51.2968 0 Hill,2(1) 1.9417186289583195 3.9088664054870605 1.7318620681762695 2.177004337310791 0.3147631170977873 1.9544332027435303 7.982062799999998 14.0186472 1.4757752000000002 4.4873348 48.521504 52.196896 CONFLICT 0.5 0.5 0.0 GO:0055088 6 lipid homeostasis 50 52 10 10 9 6 5 5 64 47 2431 0.99758 0.012212 0.012212 9.62 259241;24539;64194;24207;114628 nr1d2;lpl;insig1;apoc3;abcg5 NR1D2_9358;LPL_32544;INSIG1_8906;APOC3_32553;ABCG5_7947 303.094264 37.6554 2.87451 409.8880221044401 237.62887112409098 356.36405409870997 178.189354 13.2791 1.13737 239.11403909355175 147.43872196838416 220.41404746117314 927.009002 101.065 8.23841 1463.5542114340785 619.1547431396668 1120.3739163780992 1.5 23.557904999999998 9.46041;900.118;37.6554;2.87451;565.363 2.2133;487.466;13.2791;1.13737;386.851 49.4216;3428.38;101.065;8.23841;1047.94 2 3 2 259241;64194 NR1D2_9358;INSIG1_8906 23.557904999999998 23.557904999999998 19.9368686244869 7.7462 7.7462 7.824702219254097 75.2433 75.2433 36.517398343529315 9.46041;37.6554 2.2133;13.2791 49.4216;101.065 3 24539;24207;114628 LPL_32544;APOC3_32553;ABCG5_7947 489.4518366666667 565.363 453.41300006264714 291.8181233333333 386.851 256.71447139784635 1494.8528033333332 1047.94 1753.3226783023645 900.118;2.87451;565.363 487.466;1.13737;386.851 3428.38;8.23841;1047.94 0 Exp 2,1(0.2);Exp 4,1(0.2);Exp 5,1(0.2);Hill,1(0.2);Linear,1(0.2) 1.8172637564776855 9.154316782951355 1.5235437154769897 2.177004337310791 0.25054124686456536 1.783576488494873 -56.18842839067804 662.3769563906781 -31.40334234878773 387.7820503487877 -355.8528265648981 2209.870830564898 DOWN 0.4 0.6 0.0 GO:0002931 4 response to ischemia 27 28 3 3 2 2 1 1 68 27 2451 0.82537 0.53845 0.53845 3.57 116686 gsr GSR_8755 69.5519 69.5519 69.5519 69.5519 41.1016 41.1016 41.1016 41.1016 124.212 124.212 124.212 124.212 69.5519 41.1016 124.212 1 0 1 116686 GSR_8755 69.5519 69.5519 41.1016 41.1016 124.212 124.212 69.5519 41.1016 124.212 0 0 Exp 4,1(1) 1.8125853538513184 1.8125853538513184 1.8125853538513184 1.8125853538513184 0.0 1.8125853538513184 69.5519 69.5519 41.1016 41.1016 124.212 124.212 UP 1.0 0.0 0.0 GO:0006790 4 sulfur compound metabolic process 86 101 16 16 15 13 12 12 57 89 2389 1.0 1.0516E-5 1.0516E-5 11.88 83472;293656;58835;116682;24426;300850;116686;24404;29739;25283;81508;296925 ugdh;rgd1307603;phgdh;kynu;gstp1;gsta4;gsr;gpx1;gclm;gclc;bhmt;aass UGDH_10131;RGD1307603_9684;PHGDH_9470;KYNU_8979;GSTP1_8762;GSTA4_8757;GSR_8755;GPX1_33050;GCLM_8700;GCLC_8699;BHMT_8143;AASS_7936 100.14152333333334 84.96645000000001 5.5396 96.3416766790579 95.84242571262207 102.12669912919917 61.46199250000001 54.389700000000005 1.97501 71.39517610188037 58.808239629839115 75.0883650523606 191.92155 148.262 14.0792 164.01234876119156 183.34799617029066 173.72420678067186 4.5 64.45905 9.5 168.09550000000002 59.3662;32.0155;122.826;100.381;122.514;339.498;69.5519;8.00432;190.233;145.958;5.5396;5.81076 25.4417;12.3892;67.6778;72.7231;84.8469;260.156;41.1016;2.69961;69.2223;96.7058;1.97501;2.60489 135.068;78.5761;246.456;161.456;216.573;486.944;124.212;25.2254;496.452;280.185;37.8319;14.0792 7 5 7 83472;58835;24426;300850;116686;29739;25283 UGDH_10131;PHGDH_9470;GSTP1_8762;GSTA4_8757;GSR_8755;GCLM_8700;GCLC_8699 149.99244285714286 122.826 94.62629358453273 92.16458571428572 69.2223 77.97500621099533 283.6985714285714 246.456 152.75521566857344 59.3662;122.826;122.514;339.498;69.5519;190.233;145.958 25.4417;67.6778;84.8469;260.156;41.1016;69.2223;96.7058 135.068;246.456;216.573;486.944;124.212;496.452;280.185 5 293656;116682;24404;81508;296925 RGD1307603_9684;KYNU_8979;GPX1_33050;BHMT_8143;AASS_7936 30.350236000000002 8.00432 40.69451594985349 18.478362 2.69961 30.63032096550361 63.433719999999994 37.8319 59.97678008493787 32.0155;100.381;8.00432;5.5396;5.81076 12.3892;72.7231;2.69961;1.97501;2.60489 78.5761;161.456;25.2254;37.8319;14.0792 0 Exp 4,4(0.34);Hill,4(0.34);Linear,1(0.09);Poly 2,3(0.25) 1.977463453602002 25.445707321166992 1.567038655281067 5.5128583908081055 1.0876383526043305 1.7912393808364868 45.631088227796035 154.65195843887065 21.066368841563857 101.85761615843616 99.1228277664572 284.7202722335428 CONFLICT 0.5833333333333334 0.4166666666666667 0.0 GO:0006259 5 DNA metabolic process 110 119 10 10 10 7 7 7 62 112 2366 0.98631 0.039737 0.039737 5.88 360243;313108;29685;312538;293502;499709;25426 top2a;mms22l;mcm6;mcm2;kif22;gar1;cyp1b1 TOP2A_10059;MMS22L_33129;MCM6_9210;MCM2_9206;KIF22_8963;GAR1_8683;CYP1B1_32710 499709(-0.07184) 143.63100800000066 3.76863 4.48597E-12 286.935875516767 80.69549139013078 178.98682383570417 110.76230300000064 0.956203 4.48597E-12 221.0117648177433 63.14038649637035 139.71505772674297 245.61428142857207 20.8956 4.48599E-12 503.9786447882262 125.76393271472278 296.39534996958156 4.5 116.72408 4.48597E-12;4.13516;1.87441;3.76863;0.961856;765.364;229.313 4.48597E-12;1.24709;0.496857;0.956203;0.281971;587.034;185.32 4.48599E-12;20.8956;9.53;22.9217;4.47267;1362.21;299.27 7 0 7 360243;313108;29685;312538;293502;499709;25426 TOP2A_10059;MMS22L_33129;MCM6_9210;MCM2_9206;KIF22_8963;GAR1_8683;CYP1B1_32710 143.63100800000066 3.76863 286.935875516767 110.76230300000064 0.956203 221.0117648177433 245.61428142857207 20.8956 503.9786447882262 4.48597E-12;4.13516;1.87441;3.76863;0.961856;765.364;229.313 4.48597E-12;1.24709;0.496857;0.956203;0.281971;587.034;185.32 4.48599E-12;20.8956;9.53;22.9217;4.47267;1362.21;299.27 0 0 Exp 2,1(0.15);Exp 4,2(0.29);Hill,3(0.43);Linear,1(0.15) 1.893201248283112 13.654404997825623 1.5280487537384033 3.1843981742858887 0.5734142995644652 1.75295889377594 -68.93406327518602 356.19607927518734 -52.965503627627484 274.4901096276288 -127.73832342658923 618.9668862837334 UP 1.0 0.0 0.0 GO:0010817 4 regulation of hormone levels 159 176 15 15 12 9 6 6 63 170 2308 0.80407 0.34108 0.47372 3.41 299270;361042;29200;24890;25426;24296 serpina6;pck2;inhba;esr1;cyp1b1;cyp1a1 SERPINA6_32325;PCK2_9440;INHBA_33300;ESR1_33192;CYP1B1_32710;CYP1A1_8415 74.85918833333334 54.4069 6.67763 83.84737695462402 82.0255886233653 91.77843727748494 50.98533 26.166559999999997 1.48195 70.35909897233421 59.346863056233644 77.12136445169804 133.11655 111.63 37.9425 97.28146459123134 135.6539199651264 105.55756110038989 25.7745;6.67763;91.8104;12.5403;229.313;83.0393 8.17372;1.48195;44.1594;3.74981;185.32;63.0271 103.274;37.9425;186.93;51.2968;299.27;119.986 3 3 3 361042;25426;24296 PCK2_9440;CYP1B1_32710;CYP1A1_8415 106.34330999999999 83.0393 113.13237668907738 83.27635 63.0271 93.57687348443791 152.3995 119.986 133.64502160855076 6.67763;229.313;83.0393 1.48195;185.32;63.0271 37.9425;299.27;119.986 3 299270;29200;24890 SERPINA6_32325;INHBA_33300;ESR1_33192 43.37506666666667 25.7745 42.464952004486385 18.694309999999998 8.17372 22.164066672276096 113.8336 103.274 68.43040332834521 25.7745;91.8104;12.5403 8.17372;44.1594;3.74981 103.274;186.93;51.2968 0 Hill,4(0.67);Linear,1(0.17);Poly 2,1(0.17) 2.502611296160555 17.049893617630005 1.528982162475586 6.292444229125977 1.7864677069797237 2.156103491783142 7.767313662188769 141.95106300447787 -5.313674473105024 107.28433447310502 55.275166438145575 210.95793356185442 CONFLICT 0.5 0.5 0.0 GO:0001701 7 in utero embryonic development 63 65 1 1 1 1 1 1 68 64 2414 0.46849 0.83607 1.0 1.54 360504 hba-a2 HBA2_32600 131.05 131.05 131.05 131.05 88.5948 88.5948 88.5948 88.5948 254.163 254.163 254.163 254.163 131.05 88.5948 254.163 0 1 0 1 360504 HBA2_32600 131.05 131.05 88.5948 88.5948 254.163 254.163 131.05 88.5948 254.163 0 Poly 2,1(1) 1.948032259941101 1.948032259941101 1.948032259941101 1.948032259941101 0.0 1.948032259941101 131.05 131.05 88.5948 88.5948 254.163 254.163 DOWN 0.0 1.0 0.0 GO:0016070 6 RNA metabolic process 159 180 8 8 8 4 4 4 65 176 2302 0.4546 0.73104 1.0 2.22 291317;499709;24890;310395 rpp38;gar1;esr1;noct RPP38_9741;GAR1_8683;ESR1_33192;CCRN4L_8232 499709(-0.07184) 590.035575 715.3199999999999 12.5403 398.65727058789383 546.1352898948992 428.2118212353424 448.5954525 510.36 3.74981 326.8636273006002 413.24808467360907 351.0299130880569 972.6767000000001 1206.9650000000001 51.2968 635.5983489853425 883.2501240960372 666.4728723592167 916.962;765.364;12.5403;665.276 769.912;587.034;3.74981;433.686 1051.72;1362.21;51.2968;1425.48 2 2 2 499709;310395 GAR1_8683;CCRN4L_8232 715.3199999999999 715.3199999999999 70.77290351540135 510.36 510.36 108.43341068139395 1393.845 1393.845 44.73864604567573 765.364;665.276 587.034;433.686 1362.21;1425.48 2 291317;24890 RPP38_9741;ESR1_33192 464.75115 464.75115 639.5227171222652 386.83090500000003 386.83090500000003 541.758480037736 551.5084 551.5084 707.4060287763457 916.962;12.5403 769.912;3.74981 1051.72;51.2968 0 Exp 2,1(0.25);Hill,1(0.25);Linear,1(0.25);Poly 2,1(0.25) 1.6744363799333575 6.703591227531433 1.5943320989608765 1.7575112581253052 0.08079410732534772 1.6758739352226257 199.35144982386407 980.7197001761359 128.26909774541173 768.9218072545882 349.7903179943645 1595.5630820056358 CONFLICT 0.5 0.5 0.0 GO:0016311 6 dephosphorylation 44 50 4 3 3 2 2 2 67 48 2430 0.84811 0.39522 0.39522 4.0 310395;54232 noct;car3 CCRN4L_8232;CAR3_8196 334.362665 334.362665 3.44933 467.98212632711136 448.6667652208285 439.1769756112653 217.908715 217.908715 2.13143 305.15516289904457 292.4425152471804 286.37230781863184 715.750565 715.750565 6.02113 1003.7089925923939 960.9053408506378 941.9288792504906 665.276;3.44933 433.686;2.13143 1425.48;6.02113 1 1 1 310395 CCRN4L_8232 665.276 665.276 433.686 433.686 1425.48 1425.48 665.276 433.686 1425.48 1 54232 CAR3_8196 3.44933 3.44933 2.13143 2.13143 6.02113 6.02113 3.44933 2.13143 6.02113 0 Exp 4,1(0.5);Linear,1(0.5) 3.446634076922497 8.516663670539856 1.7575112581253052 6.759152412414551 3.5366943772596366 4.258331835269928 -314.22747159999983 982.9528015999998 -205.01476359999995 640.8321936 -675.3191275999998 2106.8202576 CONFLICT 0.5 0.5 0.0 GO:0048583 4 regulation of response to stimulus 781 832 47 47 38 31 23 23 46 809 1669 0.60376 0.49837 0.89701 2.76 308843;192247;94195;287877;338475;259241;316351;59107;24539;288001;64194;29200;25663;24426;24404;29739;25283;84586;25317;24890;25426;117517;24207 tsku;sez6;s100a9;pycr1;nrep;nr1d2;npas2;ltbp1;lpl;kng1;insig1;inhba;il1r1;gstp1;gpx1;gclm;gclc;fgl2;fgf1;esr1;cyp1b1;c7;apoc3 TSKU_10094;SEZ6_9819;S100A9_9775;PYCR1_9631;NREP_9364;NR1D2_9358;NPAS2_9350;LTBP1_33264;LPL_32544;KNG1L1_32433;INSIG1_8906;INHBA_33300;IL1R1_8893;GSTP1_8762;GPX1_33050;GCLM_8700;GCLC_8699;FGL2_32918;FGF1_8633;ESR1_33192;CYP1B1_32710;C7_8179;APOC3_32553 288001(0.1788) 215.99495652173914 103.858 2.87451 297.76146001840135 170.14966702157147 245.95103710592355 134.75430304347827 49.0864 1.13737 206.68579657301802 103.96697343369769 163.52377446105262 518.0106221739131 216.573 8.23841 826.7983031629251 402.43646784219436 695.8297317084334 92.2997;10.6392;963.318;132.668;191.159;9.46041;53.0014;769.394;900.118;3.87556;37.6554;91.8104;76.6218;122.514;8.00432;190.233;145.958;146.406;674.162;12.5403;229.313;103.858;2.87451 49.0864;3.96047;802.143;90.3184;115.886;2.2133;14.3825;438.027;487.466;1.25511;13.2791;44.1594;27.5215;84.8469;2.69961;69.2223;96.7058;95.6156;437.622;3.74981;185.32;32.7314;1.13737 185.899;29.4997;1158.68;239.858;448.068;49.4216;215.15;2211.2;3428.38;13.8374;101.065;186.93;185.143;216.573;25.2254;496.452;280.185;325.091;1465.0;51.2968;299.27;293.781;8.23841 12 11 12 308843;94195;287877;259241;288001;64194;25663;24426;29739;25283;25317;25426 TSKU_10094;S100A9_9775;PYCR1_9631;NR1D2_9358;KNG1L1_32433;INSIG1_8906;IL1R1_8893;GSTP1_8762;GCLM_8700;GCLC_8699;FGF1_8633;CYP1B1_32710 223.17323916666666 127.59100000000001 292.85433564634224 154.96115083333333 77.03460000000001 236.2556925784645 390.94866666666667 228.21550000000002 452.8018805936881 92.2997;963.318;132.668;9.46041;3.87556;37.6554;76.6218;122.514;190.233;145.958;674.162;229.313 49.0864;802.143;90.3184;2.2133;1.25511;13.2791;27.5215;84.8469;69.2223;96.7058;437.622;185.32 185.899;1158.68;239.858;49.4216;13.8374;101.065;185.143;216.573;496.452;280.185;1465.0;299.27 11 192247;338475;316351;59107;24539;29200;24404;84586;24890;117517;24207 SEZ6_9819;NREP_9364;NPAS2_9350;LTBP1_33264;LPL_32544;INHBA_33300;GPX1_33050;FGL2_32918;ESR1_33192;C7_8179;APOC3_32553 208.16410272727273 91.8104 317.15427740005276 112.7104690909091 32.7314 177.64827467150798 656.6236645454545 215.15 1112.5955401496403 10.6392;191.159;53.0014;769.394;900.118;91.8104;8.00432;146.406;12.5403;103.858;2.87451 3.96047;115.886;14.3825;438.027;487.466;44.1594;2.69961;95.6156;3.74981;32.7314;1.13737 29.4997;448.068;215.15;2211.2;3428.38;186.93;25.2254;325.091;51.2968;293.781;8.23841 0 Exp 2,2(0.09);Exp 4,3(0.14);Exp 5,1(0.05);Hill,9(0.4);Linear,2(0.09);Poly 2,6(0.27) 2.0834544996895534 50.97388005256653 1.5140434503555298 5.5128583908081055 0.9432119999341249 1.7846373319625854 94.3033460472877 337.68656699619066 50.28424622144675 219.22435986550985 180.10786926820697 855.9133750796191 CONFLICT 0.5217391304347826 0.4782608695652174 0.0 GO:0045600 7 positive regulation of fat cell differentiation 16 17 2 2 2 2 2 2 67 15 2463 0.99014 0.075732 0.075732 11.76 24539;310395 lpl;noct LPL_32544;CCRN4L_8232 782.697 782.697 665.276 166.05837070741168 750.6454115887105 159.7522264089813 460.576 460.576 433.686 38.02820269221227 453.2360249326818 36.58406390796794 2426.9300000000003 2426.9300000000003 1425.48 1416.2641720385348 2153.5712037498756 1362.4808776732848 0.0 665.276 0.5 782.697 900.118;665.276 487.466;433.686 3428.38;1425.48 1 1 1 310395 CCRN4L_8232 665.276 665.276 433.686 433.686 1425.48 1425.48 665.276 433.686 1425.48 1 24539 LPL_32544 900.118 900.118 487.466 487.466 3428.38 3428.38 900.118 487.466 3428.38 0 Exp 2,1(0.5);Linear,1(0.5) 1.7303742817670922 3.461167573928833 1.7036563158035278 1.7575112581253052 0.03808119491613915 1.7305837869644165 552.5518399999999 1012.8421600000001 407.8716 513.2804000000001 464.0880000000004 4389.772 CONFLICT 0.5 0.5 0.0 GO:0042981 7 regulation of apoptotic process 428 455 23 23 19 14 11 11 58 444 2034 0.40816 0.71209 0.75221 2.42 360243;94195;24567;29200;24426;24404;29739;25283;24890;25426;25612 top2a;s100a9;mt1;inhba;gstp1;gpx1;gclm;gclc;esr1;cyp1b1;asns TOP2A_10059;S100A9_9775;MT1A_9255;INHBA_33300;GSTP1_8762;GPX1_33050;GCLM_8700;GCLC_8699;ESR1_33192;CYP1B1_32710;ASNS_8091 235.2801000000004 122.514 4.48597E-12 335.0375714450197 149.8705342493337 224.0223543463566 166.52787454545495 69.2223 4.48597E-12 262.27562287117604 103.49159064489007 176.50458006754303 337.9493000000004 216.573 4.48599E-12 395.3739124670491 238.42074795163373 282.0647839598731 4.48597E-12;963.318;818.334;91.8104;122.514;8.00432;190.233;145.958;12.5403;229.313;6.05608 4.48597E-12;802.143;540.216;44.1594;84.8469;2.69961;69.2223;96.7058;3.74981;185.32;2.7438 4.48599E-12;1158.68;988.495;186.93;216.573;25.2254;496.452;280.185;51.2968;299.27;14.3351 7 4 7 360243;94195;24426;29739;25283;25426;25612 TOP2A_10059;S100A9_9775;GSTP1_8762;GCLM_8700;GCLC_8699;CYP1B1_32710;ASNS_8091 236.77029714285777 145.958 331.83416897177875 177.28311428571493 84.8469 282.5839226442554 352.21358571428635 280.185 394.92585538680663 4.48597E-12;963.318;122.514;190.233;145.958;229.313;6.05608 4.48597E-12;802.143;84.8469;69.2223;96.7058;185.32;2.7438 4.48599E-12;1158.68;216.573;496.452;280.185;299.27;14.3351 4 24567;29200;24404;24890 MT1A_9255;INHBA_33300;GPX1_33050;ESR1_33192 232.67225499999998 52.17535 392.332979487141 147.706205 23.954605 262.3840926654028 312.9868 119.1134 455.88372952009007 818.334;91.8104;8.00432;12.5403 540.216;44.1594;2.69961;3.74981 988.495;186.93;25.2254;51.2968 0 Hill,6(0.55);Linear,1(0.1);Poly 2,4(0.37) 2.316695085499393 27.503602743148804 1.7056305408477783 5.5128583908081055 1.1776540973942105 1.90879225730896 37.28554784510584 433.27465215489497 11.532886169811803 321.52286292109807 104.29824888053497 571.6003511194659 UP 0.6363636363636364 0.36363636363636365 0.0 GO:0009893 5 positive regulation of metabolic process 777 837 41 41 35 24 19 19 50 818 1660 0.20606 0.86168 0.36608 2.27 360243;94195;24614;259241;316351;59107;24539;170496;64194;29200;25663;24426;25283;25317;24890;24309;25426;310395;24207 top2a;s100a9;orm1;nr1d2;npas2;ltbp1;lpl;lcn2;insig1;inhba;il1r1;gstp1;gclc;fgf1;esr1;dbp;cyp1b1;noct;apoc3 TOP2A_10059;S100A9_9775;ORM1_9400;NR1D2_9358;NPAS2_9350;LTBP1_33264;LPL_32544;LCN2_32481;INSIG1_8906;INHBA_33300;IL1R1_8893;GSTP1_8762;GCLC_8699;FGF1_8633;ESR1_33192;DBP_8439;CYP1B1_32710;CCRN4L_8232;APOC3_32553 339.7458378947371 122.514 4.48597E-12 374.9863366462589 261.83776219540187 335.5909553325741 214.55924105263182 84.8469 4.48597E-12 249.8760315470706 163.82483093931987 215.2396764061929 897.912147894737 280.185 4.48599E-12 1200.7158905661765 691.299763963369 1078.7164191608665 4.48597E-12;963.318;662.49;9.46041;53.0014;769.394;900.118;972.626;37.6554;91.8104;76.6218;122.514;145.958;674.162;12.5403;66.0377;229.313;665.276;2.87451 4.48597E-12;802.143;432.445;2.2133;14.3825;438.027;487.466;551.931;13.2791;44.1594;27.5215;84.8469;96.7058;437.622;3.74981;19.9899;185.32;433.686;1.13737 4.48599E-12;1158.68;1413.32;49.4216;215.15;2211.2;3428.38;4084.57;101.065;186.93;185.143;216.573;280.185;1465.0;51.2968;280.428;299.27;1425.48;8.23841 13 6 13 360243;94195;24614;259241;170496;64194;25663;24426;25283;25317;24309;25426;310395 TOP2A_10059;S100A9_9775;ORM1_9400;NR1D2_9358;LCN2_32481;INSIG1_8906;IL1R1_8893;GSTP1_8762;GCLC_8699;FGF1_8633;DBP_8439;CYP1B1_32710;CCRN4L_8232 355.80248538461575 145.958 372.4758748491585 237.5156538461542 96.7058 263.5528596380383 843.010430769231 280.428 1129.3000011417155 4.48597E-12;963.318;662.49;9.46041;972.626;37.6554;76.6218;122.514;145.958;674.162;66.0377;229.313;665.276 4.48597E-12;802.143;432.445;2.2133;551.931;13.2791;27.5215;84.8469;96.7058;437.622;19.9899;185.32;433.686 4.48599E-12;1158.68;1413.32;49.4216;4084.57;101.065;185.143;216.573;280.185;1465.0;280.428;299.27;1425.48 6 316351;59107;24539;29200;24890;24207 NPAS2_9350;LTBP1_33264;LPL_32544;INHBA_33300;ESR1_33192;APOC3_32553 304.956435 72.4059 413.6647912391131 164.82034666666667 29.27095 231.80532238636883 1016.8658683333333 201.04000000000002 1450.7259754896336 53.0014;769.394;900.118;91.8104;12.5403;2.87451 14.3825;438.027;487.466;44.1594;3.74981;1.13737 215.15;2211.2;3428.38;186.93;51.2968;8.23841 0 Exp 2,2(0.11);Exp 4,2(0.11);Exp 5,1(0.06);Hill,6(0.32);Linear,5(0.27);Poly 2,3(0.16) 1.9760113075045462 39.796117186546326 1.5140434503555298 5.5128583908081055 0.9280047195744044 1.7575112581253052 171.13141729299244 508.3602584964817 102.20127447072353 326.9172076345401 358.0044381743394 1437.8198576151347 UP 0.6842105263157895 0.3157894736842105 0.0 GO:0045931 7 positive regulation of mitotic cell cycle 58 63 3 3 3 2 2 2 67 61 2417 0.75763 0.51452 0.68795 3.17 24296;25612 cyp1a1;asns CYP1A1_8415;ASNS_8091 44.547689999999996 44.547689999999996 6.05608 54.43535689957586 62.957751696951036 47.805306582147466 32.88545 32.88545 2.7438 42.626730222302996 47.30182894979981 37.434932421423404 67.16055 67.16055 14.3351 74.70646782846183 92.42631034801356 65.60746179725665 83.0393;6.05608 63.0271;2.7438 119.986;14.3351 2 0 2 24296;25612 CYP1A1_8415;ASNS_8091 44.547689999999996 44.547689999999996 54.43535689957586 32.88545 32.88545 42.626730222302996 67.16055 67.16055 74.70646782846183 83.0393;6.05608 63.0271;2.7438 119.986;14.3351 0 0 Hill,1(0.5);Poly 2,1(0.5) 4.714625155985912 9.824885606765747 3.5324413776397705 6.292444229125977 1.951616732380104 4.9124428033828735 -30.8958656 119.99124559999998 -26.192183999999983 91.96308399999998 -36.37733200000001 170.69843200000003 UP 1.0 0.0 0.0 GO:0061024 5 membrane organization 110 116 5 5 5 3 3 3 66 113 2365 0.61433 0.61694 1.0 2.59 25283;301111;114628 gclc;ano10;abcg5 GCLC_8699;ANO10_8049;ABCG5_7947 240.4139 145.958 9.9207 289.5176591175917 327.2916629633433 302.3924247563201 162.15776666666667 96.7058 2.9165 200.1609228295157 222.22849519457853 209.07651047560972 453.7711 280.185 33.1883 529.1779981708708 612.6091415340384 552.8017639340603 145.958;9.9207;565.363 96.7058;2.9165;386.851 280.185;33.1883;1047.94 2 1 2 25283;301111 GCLC_8699;ANO10_8049 77.93935 77.93935 96.19289732430872 49.81115 49.81115 66.31905003273945 156.68665 156.68665 174.65304150069935 145.958;9.9207 96.7058;2.9165 280.185;33.1883 1 114628 ABCG5_7947 565.363 565.363 386.851 386.851 1047.94 1047.94 565.363 386.851 1047.94 0 Hill,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 1.703770612656786 5.1191524267196655 1.575217366218567 1.783576488494873 0.11418542052464103 1.7603585720062256 -87.20617291631606 568.0339729163161 -64.34564017998835 388.6611735133216 -145.0501769986319 1052.5923769986318 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0006883 9 cellular sodium ion homeostasis 4 4 1 1 1 1 1 1 68 3 2475 0.99581 0.1041 0.1041 25.0 117517 c7 C7_8179 103.858 103.858 103.858 103.858 32.7314 32.7314 32.7314 32.7314 293.781 293.781 293.781 293.781 0.0 103.858 0.0 103.858 103.858 32.7314 293.781 0 1 0 1 117517 C7_8179 103.858 103.858 32.7314 32.7314 293.781 293.781 103.858 32.7314 293.781 0 Hill,1(1) 1.9308089017868042 1.9308089017868042 1.9308089017868042 1.9308089017868042 0.0 1.9308089017868042 103.858 103.858 32.7314 32.7314 293.781 293.781 DOWN 0.0 1.0 0.0 GO:0030001 7 metal ion transport 103 108 3 3 3 2 2 2 67 106 2372 0.43256 0.80007 1.0 1.85 266730;170496 slc17a3;lcn2 SLC17A3_9840;LCN2_32481 533.00495 533.00495 93.3839 621.7180512147006 407.20734630872477 595.7207911574607 310.42810000000003 310.42810000000003 68.9252 341.5366765324333 241.32202306284321 327.25525462172726 2113.994 2113.994 143.418 2786.815304886924 1550.1134972544235 2670.284086159896 93.3839;972.626 68.9252;551.931 143.418;4084.57 2 0 2 266730;170496 SLC17A3_9840;LCN2_32481 533.00495 533.00495 621.7180512147006 310.42810000000003 310.42810000000003 341.5366765324333 2113.994 2113.994 2786.815304886924 93.3839;972.626 68.9252;551.931 143.418;4084.57 0 0 Linear,1(0.5);Poly 2,1(0.5) 1.6713913179303133 3.361332654953003 1.504341721534729 1.856990933418274 0.24936064910294622 1.6806663274765015 -328.65230799999983 1394.6622079999997 -162.91758399999998 783.773784 -1748.3349599999992 5976.3229599999995 UP 1.0 0.0 0.0 GO:0031347 6 regulation of defense response 154 164 11 11 9 10 8 8 61 156 2322 0.96944 0.072401 0.081896 4.88 94195;259241;316351;24539;25663;24404;84586;24890 s100a9;nr1d2;npas2;lpl;il1r1;gpx1;fgl2;esr1 S100A9_9775;NR1D2_9358;NPAS2_9350;LPL_32544;IL1R1_8893;GPX1_33050;FGL2_32918;ESR1_33192 271.18377875 64.8116 8.00432 410.625731794832 166.21085931241004 347.3128659758704 179.473915 20.951999999999998 2.2133 300.83272147716923 100.44232761215086 232.97000438221525 679.798475 200.1465 25.2254 1170.5482733789663 489.62702224589697 1106.9941921088496 963.318;9.46041;53.0014;900.118;76.6218;8.00432;146.406;12.5403 802.143;2.2133;14.3825;487.466;27.5215;2.69961;95.6156;3.74981 1158.68;49.4216;215.15;3428.38;185.143;25.2254;325.091;51.2968 3 5 3 94195;259241;25663 S100A9_9775;NR1D2_9358;IL1R1_8893 349.80007 76.6218 532.382241345724 277.2926 27.5215 454.70988886534013 464.4148666666667 185.143 605.0686995096122 963.318;9.46041;76.6218 802.143;2.2133;27.5215 1158.68;49.4216;185.143 5 316351;24539;24404;84586;24890 NPAS2_9350;LPL_32544;GPX1_33050;FGL2_32918;ESR1_33192 224.01400400000003 53.0014 382.0229827785733 120.78270400000001 14.3825 208.59730431326295 809.02864 215.15 1469.3871244480767 53.0014;900.118;8.00432;146.406;12.5403 14.3825;487.466;2.69961;95.6156;3.74981 215.15;3428.38;25.2254;325.091;51.2968 0 Exp 2,1(0.13);Hill,5(0.63);Poly 2,2(0.25) 1.8629696225096217 15.096612811088562 1.6593536138534546 2.6413023471832275 0.3471361565081734 1.718746304512024 -13.365335942177921 555.7328934421779 -28.992525212124093 387.940355212124 -131.35009437622227 1490.9470443762225 DOWN 0.375 0.625 0.0 GO:0034097 5 response to cytokine 230 247 12 12 11 9 8 8 61 239 2239 0.77938 0.35201 0.53722 3.24 361042;312538;170496;116682;25663;29739;25283;25426 pck2;mcm2;lcn2;kynu;il1r1;gclm;gclc;cyp1b1 PCK2_9440;MCM2_9206;LCN2_32481;KYNU_8979;IL1R1_8893;GCLM_8700;GCLC_8699;CYP1B1_32710 215.6973825 123.1695 3.76863 316.20094697380637 186.82207044474396 273.42912047076993 125.73273162500001 70.9727 0.956203 182.3240850999339 114.21637408237872 160.40306736780622 695.992525 232.664 22.9217 1377.6433858225396 541.8432953504044 1173.529358647451 6.67763;3.76863;972.626;100.381;76.6218;190.233;145.958;229.313 1.48195;0.956203;551.931;72.7231;27.5215;69.2223;96.7058;185.32 37.9425;22.9217;4084.57;161.456;185.143;496.452;280.185;299.27 7 1 7 361042;312538;170496;25663;29739;25283;25426 PCK2_9440;MCM2_9206;LCN2_32481;IL1R1_8893;GCLM_8700;GCLC_8699;CYP1B1_32710 232.17115142857142 145.958 337.8075656736276 133.30553614285716 69.2223 195.56885037833334 772.3548857142857 280.185 1469.6236095232032 6.67763;3.76863;972.626;76.6218;190.233;145.958;229.313 1.48195;0.956203;551.931;27.5215;69.2223;96.7058;185.32 37.9425;22.9217;4084.57;185.143;496.452;280.185;299.27 1 116682 KYNU_8979 100.381 100.381 72.7231 72.7231 161.456 161.456 100.381 72.7231 161.456 0 Hill,4(0.5);Linear,2(0.25);Poly 2,2(0.25) 1.8766865514895592 15.418218970298767 1.5280487537384033 3.1843981742858887 0.532814544207657 1.8086747527122498 -3.4186946463306924 434.81345964633067 -0.6114133838404712 252.07687663384047 -258.6656355684746 1650.6506855684743 UP 0.875 0.125 0.0 GO:0006974 5 cellular response to DNA damage stimulus 142 151 9 9 8 6 5 5 64 146 2332 0.77754 0.38944 0.60172 3.31 360243;313108;29685;312538;293502 top2a;mms22l;mcm6;mcm2;kif22 TOP2A_10059;MMS22L_33129;MCM6_9210;MCM2_9206;KIF22_8963 2.148011200000897 1.87441 4.48597E-12 1.7798131600458462 2.191611008024888 1.7198527339121825 0.5964242000008972 0.496857 4.48597E-12 0.5043121644540832 0.6199714888075366 0.5028767360340293 11.563994000000898 9.53 4.48599E-12 10.052690199874565 11.479571153332483 9.400237964421096 4.48597E-12;4.13516;1.87441;3.76863;0.961856 4.48597E-12;1.24709;0.496857;0.956203;0.281971 4.48599E-12;20.8956;9.53;22.9217;4.47267 5 0 5 360243;313108;29685;312538;293502 TOP2A_10059;MMS22L_33129;MCM6_9210;MCM2_9206;KIF22_8963 2.148011200000897 1.87441 1.7798131600458462 0.5964242000008972 0.496857 0.5043121644540832 11.563994000000898 9.53 10.052690199874565 4.48597E-12;4.13516;1.87441;3.76863;0.961856 4.48597E-12;1.24709;0.496857;0.956203;0.281971 4.48599E-12;20.8956;9.53;22.9217;4.47267 0 0 Exp 4,2(0.4);Hill,3(0.6) 1.760245091544224 8.850121021270752 1.5280487537384033 2.092013359069824 0.21104256334634544 1.75295889377594 0.5879361804612968 3.7080862195404976 0.1543750976139392 1.0384733023878554 2.752422531684033 20.37556546831776 UP 1.0 0.0 0.0 GO:0032355 5 response to estradiol 114 121 14 14 9 10 6 6 63 115 2363 0.95708 0.10659 0.13979 4.96 64194;360504;24426;24404;24890;25426 insig1;hba-a2;gstp1;gpx1;esr1;cyp1b1 INSIG1_8906;HBA2_32600;GSTP1_8762;GPX1_33050;ESR1_33192;CYP1B1_32710 90.17950333333333 80.0847 8.00432 86.73342510039869 100.84221454649696 100.60012480251474 63.08170333333334 49.063 2.69961 71.71249977519976 73.61097894937507 84.50880617951285 157.9322 158.81900000000002 25.2254 113.92239967395348 164.35307266368534 124.44301578012282 37.6554;131.05;122.514;8.00432;12.5403;229.313 13.2791;88.5948;84.8469;2.69961;3.74981;185.32 101.065;254.163;216.573;25.2254;51.2968;299.27 3 3 3 64194;24426;25426 INSIG1_8906;GSTP1_8762;CYP1B1_32710 129.82746666666665 122.514 96.03787797246109 94.48200000000001 84.8469 86.42421062532188 205.636 216.573 99.55410078444778 37.6554;122.514;229.313 13.2791;84.8469;185.32 101.065;216.573;299.27 3 360504;24404;24890 HBA2_32600;GPX1_33050;ESR1_33192 50.53154000000001 12.5403 69.76790507976285 31.68140666666667 3.74981 49.29124146890635 110.22840000000001 51.2968 125.33078744809673 131.05;8.00432;12.5403 88.5948;2.69961;3.74981 254.163;25.2254;51.2968 0 Exp 5,1(0.17);Hill,2(0.34);Linear,1(0.17);Poly 2,2(0.34) 2.433852478326196 16.128324151039124 1.7318620681762695 5.5128583908081055 1.484894782758155 1.9572840929031372 20.778309187639323 159.58069747902732 5.699752674627021 120.46365399203965 66.77529517163238 249.08910482836762 CONFLICT 0.5 0.5 0.0 GO:0007059 3 chromosome segregation 37 37 6 6 6 2 2 2 67 35 2443 0.92319 0.26502 0.26502 5.41 360243;287598 top2a;ska2 TOP2A_10059;LOC691962_32591 1.2365600000022432 1.2365600000022432 4.48597E-12 1.7487599226849022 1.3168673184378517 1.7450681179828682 0.405246500002243 0.405246500002243 4.48597E-12 0.5731050964010563 0.4315648830328236 0.5718952150089869 5.191900000002243 5.191900000002243 4.48599E-12 7.342455394481701 5.529083449722768 7.326954746852376 0.5 1.2365600000022432 4.48597E-12;2.47312 4.48597E-12;0.810493 4.48599E-12;10.3838 2 0 2 360243;287598 TOP2A_10059;LOC691962_32591 1.2365600000022432 1.2365600000022432 1.7487599226849022 0.405246500002243 0.405246500002243 0.5731050964010563 5.191900000002243 5.191900000002243 7.342455394481701 4.48597E-12;2.47312 4.48597E-12;0.810493 4.48599E-12;10.3838 0 0 Exp 4,1(0.5);Hill,1(0.5) 1.623454461475527 3.256476402282715 1.503517508506775 1.75295889377594 0.1763816950323928 1.6282382011413574 -1.1870975999933608 3.660217599997847 -0.38903663999336074 1.1995296399978468 -4.984223999993359 15.368023999997847 UP 1.0 0.0 0.0 GO:0015893 5 drug transport 30 33 5 4 4 4 3 3 66 30 2448 0.98884 0.058181 0.058181 9.09 287167;29200;360504 hba-a1;inhba;hba-a2 LOC287167_9118;INHBA_33300;HBA2_32600 124.0474666666667 131.05 91.8104 29.368738591456893 129.36991096601176 27.830761441053774 76.58553333333333 88.5948 44.1594 28.394762310210176 81.39813173205853 26.273032659218906 258.415 254.163 186.93 73.70304572404036 272.37264111234185 72.85134525157208 0.5 111.43020000000001 149.282;91.8104;131.05 97.0024;44.1594;88.5948 334.152;186.93;254.163 0 3 0 3 287167;29200;360504 LOC287167_9118;INHBA_33300;HBA2_32600 124.0474666666667 131.05 29.368738591456893 76.58553333333333 88.5948 28.394762310210176 258.415 254.163 73.70304572404036 149.282;91.8104;131.05 97.0024;44.1594;88.5948 334.152;186.93;254.163 0 Hill,1(0.34);Poly 2,2(0.67) 1.9819787500682555 5.9839078187942505 1.743384599685669 2.2924909591674805 0.2775038301069376 1.948032259941101 90.81361036885329 157.28132296448004 44.45383495311775 108.71723171354891 175.0121523538147 341.8178476461853 DOWN 0.0 1.0 0.0 GO:0010646 5 regulation of cell communication 678 722 39 39 31 26 19 19 50 703 1775 0.50102 0.60619 1.0 2.63 308843;192247;94195;361042;24614;338475;59107;24539;64194;29200;25663;24426;24404;29739;25283;25317;24890;25426;24207 tsku;sez6;s100a9;pck2;orm1;nrep;ltbp1;lpl;insig1;inhba;il1r1;gstp1;gpx1;gclm;gclc;fgf1;esr1;cyp1b1;apoc3 TSKU_10094;SEZ6_9819;S100A9_9775;PCK2_9440;ORM1_9400;NREP_9364;LTBP1_33264;LPL_32544;INSIG1_8906;INHBA_33300;IL1R1_8893;GSTP1_8762;GPX1_33050;GCLM_8700;GCLC_8699;FGF1_8633;ESR1_33192;CYP1B1_32710;APOC3_32553 273.0411715789474 122.514 2.87451 332.7764666744797 200.16609533597688 280.02792243011 173.51366368421054 69.2223 1.13737 230.20071221084194 125.39639563464557 185.36664858596785 643.5983057894737 216.573 8.23841 914.1211360211735 470.38347074850674 783.2600451449237 92.2997;10.6392;963.318;6.67763;662.49;191.159;769.394;900.118;37.6554;91.8104;76.6218;122.514;8.00432;190.233;145.958;674.162;12.5403;229.313;2.87451 49.0864;3.96047;802.143;1.48195;432.445;115.886;438.027;487.466;13.2791;44.1594;27.5215;84.8469;2.69961;69.2223;96.7058;437.622;3.74981;185.32;1.13737 185.899;29.4997;1158.68;37.9425;1413.32;448.068;2211.2;3428.38;101.065;186.93;185.143;216.573;25.2254;496.452;280.185;1465.0;51.2968;299.27;8.23841 11 8 11 308843;94195;361042;24614;64194;25663;24426;29739;25283;25317;25426 TSKU_10094;S100A9_9775;PCK2_9440;ORM1_9400;INSIG1_8906;IL1R1_8893;GSTP1_8762;GCLM_8700;GCLC_8699;FGF1_8633;CYP1B1_32710 291.0220481818182 145.958 321.04141985506493 199.9703590909091 84.8469 253.20291692710492 530.8663181818182 280.185 541.1241073136677 92.2997;963.318;6.67763;662.49;37.6554;76.6218;122.514;190.233;145.958;674.162;229.313 49.0864;802.143;1.48195;432.445;13.2791;27.5215;84.8469;69.2223;96.7058;437.622;185.32 185.899;1158.68;37.9425;1413.32;101.065;185.143;216.573;496.452;280.185;1465.0;299.27 8 192247;338475;59107;24539;29200;24404;24890;24207 SEZ6_9819;NREP_9364;LTBP1_33264;LPL_32544;INHBA_33300;GPX1_33050;ESR1_33192;APOC3_32553 248.31746625 52.17535 369.20778611154793 137.1357075 24.059935 205.0989591181645 798.60478875 119.1134 1297.3022304108829 10.6392;191.159;769.394;900.118;91.8104;8.00432;12.5403;2.87451 3.96047;115.886;438.027;487.466;44.1594;2.69961;3.74981;1.13737 29.4997;448.068;2211.2;3428.38;186.93;25.2254;51.2968;8.23841 0 Exp 2,2(0.11);Exp 4,2(0.11);Exp 5,1(0.06);Hill,7(0.37);Linear,3(0.16);Poly 2,4(0.22) 2.068379326041613 42.30295646190643 1.5140434503555298 5.5128583908081055 1.0354791306658568 1.7603585720062256 123.40662323766992 422.6757199202249 70.00279963863302 277.0245277297881 232.559314106371 1054.6372974725764 CONFLICT 0.5789473684210527 0.42105263157894735 0.0 GO:0048878 5 chemical homeostasis 274 291 25 25 22 18 15 15 54 276 2202 0.99627 0.0092608 0.011347 5.15 361042;259241;24567;24539;288001;64194;25663;24404;29739;25283;24890;117517;24207;25748;114628 pck2;nr1d2;mt1;lpl;kng1;insig1;il1r1;gpx1;gclm;gclc;esr1;c7;apoc3;alas2;abcg5 PCK2_9440;NR1D2_9358;MT1A_9255;LPL_32544;KNG1L1_32433;INSIG1_8906;IL1R1_8893;GPX1_33050;GCLM_8700;GCLC_8699;ESR1_33192;C7_8179;APOC3_32553;ALAS2_8019;ABCG5_7947 288001(0.1788) 200.47199533333333 76.6218 2.87451 303.35988296883 148.50599443820164 248.92414080726655 116.82139666666666 27.5215 1.13737 188.59286283300665 85.55340635498801 157.09095041559561 482.9443406666667 185.143 8.23841 880.3325042882489 367.86167579962756 718.2942963964731 13.5 859.226 6.67763;9.46041;818.334;900.118;3.87556;37.6554;76.6218;8.00432;190.233;145.958;12.5403;103.858;2.87451;125.506;565.363 1.48195;2.2133;540.216;487.466;1.25511;13.2791;27.5215;2.69961;69.2223;96.7058;3.74981;32.7314;1.13737;85.7907;386.851 37.9425;49.4216;988.495;3428.38;13.8374;101.065;185.143;25.2254;496.452;280.185;51.2968;293.781;8.23841;236.762;1047.94 7 8 7 361042;259241;288001;64194;25663;29739;25283 PCK2_9440;NR1D2_9358;KNG1L1_32433;INSIG1_8906;IL1R1_8893;GCLM_8700;GCLC_8699 67.21168571428571 37.6554 74.50771394807295 30.239865714285713 13.2791 38.04609015143863 166.29235714285713 101.065 173.18672600485155 6.67763;9.46041;3.87556;37.6554;76.6218;190.233;145.958 1.48195;2.2133;1.25511;13.2791;27.5215;69.2223;96.7058 37.9425;49.4216;13.8374;101.065;185.143;496.452;280.185 8 24567;24539;24404;24890;117517;24207;25748;114628 MT1A_9255;LPL_32544;GPX1_33050;ESR1_33192;C7_8179;APOC3_32553;ALAS2_8019;ABCG5_7947 317.07476625 114.682 382.09849952588996 192.58023624999998 59.26105 236.30095102653334 760.0148262499999 265.2715 1155.9664366461132 818.334;900.118;8.00432;12.5403;103.858;2.87451;125.506;565.363 540.216;487.466;2.69961;3.74981;32.7314;1.13737;85.7907;386.851 988.495;3428.38;25.2254;51.2968;293.781;8.23841;236.762;1047.94 0 Exp 2,1(0.07);Exp 4,2(0.14);Exp 5,1(0.07);Hill,7(0.47);Linear,1(0.07);Poly 2,3(0.2) 1.7985004707770964 27.16430175304413 1.5235437154769897 2.3371741771698 0.22598090855085268 1.7603585720062256 46.95071277962734 353.9932778870393 21.38023978313356 212.26255355019975 37.43462524416168 928.4540560891717 CONFLICT 0.4666666666666667 0.5333333333333333 0.0 GO:0051276 6 chromosome organization 85 90 10 10 10 5 5 5 64 85 2393 0.96696 0.094275 0.094275 5.56 360243;29685;312538;293502;499709 top2a;mcm6;mcm2;kif22;gar1 TOP2A_10059;MCM6_9210;MCM2_9206;KIF22_8963;GAR1_8683 499709(-0.07184) 154.3937792000009 1.87441 4.48597E-12 341.5455673733728 51.13064796441421 210.44277604939663 117.7538062000009 0.496857 4.48597E-12 262.3358360393046 38.500649337819006 161.61792993005065 279.8268740000009 9.53 4.48599E-12 605.1315801221989 96.18938028841335 373.1000463677565 3.5 384.56631500000003 4.48597E-12;1.87441;3.76863;0.961856;765.364 4.48597E-12;0.496857;0.956203;0.281971;587.034 4.48599E-12;9.53;22.9217;4.47267;1362.21 5 0 5 360243;29685;312538;293502;499709 TOP2A_10059;MCM6_9210;MCM2_9206;KIF22_8963;GAR1_8683 154.3937792000009 1.87441 341.5455673733728 117.7538062000009 0.496857 262.3358360393046 279.8268740000009 9.53 605.1315801221989 4.48597E-12;1.87441;3.76863;0.961856;765.364 4.48597E-12;0.496857;0.956203;0.281971;587.034 4.48599E-12;9.53;22.9217;4.47267;1362.21 0 0 Exp 2,1(0.2);Exp 4,1(0.2);Hill,3(0.6) 1.7525158818012059 8.814083218574524 1.5280487537384033 2.092013359069824 0.21645940873701652 1.75295889377594 -144.98411037575264 453.7716687757545 -112.19369262870383 347.7013050287056 -250.59434260615723 810.2480906061592 UP 1.0 0.0 0.0 GO:0018130 5 heterocycle biosynthetic process 162 180 8 8 8 6 6 6 63 174 2304 0.78846 0.36096 0.62992 3.33 83472;287877;116682;499709;24890;25748 ugdh;pycr1;kynu;gar1;esr1;alas2 UGDH_10131;PYCR1_9631;KYNU_8979;GAR1_8683;ESR1_33192;ALAS2_8019 499709(-0.07184) 199.30425 112.9435 12.5403 280.9126028981808 129.21711333495773 186.33003268539318 144.176285 79.2569 3.74981 219.70687665622972 89.69297716592989 145.30011823251786 364.4418 199.10899999999998 51.2968 493.8096802685829 240.2722651676007 325.9075813892872 59.3662;132.668;100.381;765.364;12.5403;125.506 25.4417;90.3184;72.7231;587.034;3.74981;85.7907 135.068;239.858;161.456;1362.21;51.2968;236.762 3 3 3 83472;287877;499709 UGDH_10131;PYCR1_9631;GAR1_8683 319.13273333333336 132.668 388.1817177354098 234.26469999999998 90.3184 307.22447952204266 579.0453333333334 239.858 680.2612787461399 59.3662;132.668;765.364 25.4417;90.3184;587.034 135.068;239.858;1362.21 3 116682;24890;25748 KYNU_8979;ESR1_33192;ALAS2_8019 79.47576666666667 100.381 59.31343801924934 54.08787 72.7231 44.08095683923729 149.83826666666667 161.456 93.27681329576679 100.381;12.5403;125.506 72.7231;3.74981;85.7907 161.456;51.2968;236.762 0 Exp 2,1(0.17);Hill,2(0.34);Poly 2,3(0.5) 1.7301243449416133 10.406258344650269 1.5737498998641968 1.957481861114502 0.13431006918585986 1.7452466487884521 -25.472646209755226 424.0811462097552 -31.6258303241988 319.9784003241988 -30.68823725694523 759.5718372569452 CONFLICT 0.5 0.5 0.0 GO:1905463 9 negative regulation of DNA duplex unwinding 3 3 2 2 2 2 2 2 67 1 2477 0.99998 0.0021326 0.0021326 66.67 360243;312538 top2a;mcm2 TOP2A_10059;MCM2_9206 1.884315000002243 1.884315000002243 4.48597E-12 2.664823828779886 1.6581341530765399 2.645556744316976 0.478101500002243 0.478101500002243 4.48597E-12 0.6761376254877483 0.4207133232982045 0.6712490468889939 11.460850000002244 11.460850000002244 4.48599E-12 16.208089506320515 10.085164533670437 16.090902536537346 0.0 4.48597E-12 0.0 4.48597E-12 4.48597E-12;3.76863 4.48597E-12;0.956203 4.48599E-12;22.9217 2 0 2 360243;312538 TOP2A_10059;MCM2_9206 1.884315000002243 1.884315000002243 2.664823828779886 0.478101500002243 0.478101500002243 0.6761376254877483 11.460850000002244 11.460850000002244 16.208089506320515 4.48597E-12;3.76863 4.48597E-12;0.956203 4.48599E-12;22.9217 0 0 Hill,2(1) 1.6366449379718788 3.2810076475143433 1.5280487537384033 1.75295889377594 0.15903548517815816 1.6405038237571716 -1.8089423999933605 5.577572399997846 -0.45897743999336066 1.4151804399978467 -11.00241599999336 33.924115999997845 UP 1.0 0.0 0.0 GO:0031175 7 neuron projection development 77 81 4 4 4 2 2 2 67 79 2399 0.6228 0.65272 1.0 2.47 58835;338475 phgdh;nrep PHGDH_9470;NREP_9364 156.9925 156.9925 122.826 48.318727678820224 153.2293035768568 48.02474518268357 91.78190000000001 91.78190000000001 67.6778 34.088345128797265 89.12700520822779 33.8809436248349 347.262 347.262 246.456 142.5612123685822 336.1589376836559 141.6938364446343 122.826;191.159 67.6778;115.886 246.456;448.068 1 1 1 58835 PHGDH_9470 122.826 122.826 67.6778 67.6778 246.456 246.456 122.826 67.6778 246.456 1 338475 NREP_9364 191.159 191.159 115.886 115.886 448.068 448.068 191.159 115.886 448.068 0 Exp 4,1(0.5);Poly 2,1(0.5) 2.0295063672089357 4.08886444568634 1.7978414297103882 2.291023015975952 0.3487320440047186 2.04443222284317 90.02616000000002 223.95884 44.53786400000001 139.025936 149.68224000000004 544.84176 CONFLICT 0.5 0.5 0.0 GO:0017121 8 plasma membrane phospholipid scrambling 3 3 1 1 1 1 1 1 68 2 2476 0.99787 0.07912 0.07912 33.33 301111 ano10 ANO10_8049 9.9207 9.9207 9.9207 9.9207 2.9165 2.9165 2.9165 2.9165 33.1883 33.1883 33.1883 33.1883 0.0 9.9207 0.0 9.9207 9.9207 2.9165 33.1883 1 0 1 301111 ANO10_8049 9.9207 9.9207 2.9165 2.9165 33.1883 33.1883 9.9207 2.9165 33.1883 0 0 Hill,1(1) 1.575217366218567 1.575217366218567 1.575217366218567 1.575217366218567 0.0 1.575217366218567 9.9207 9.9207 2.9165 2.9165 33.1883 33.1883 UP 1.0 0.0 0.0 GO:0010243 5 response to organonitrogen compound 400 420 28 28 21 19 12 12 57 408 2070 0.65495 0.47007 0.8691 2.86 361042;24614;116682;64194;24426;24404;29739;25283;25426;81508;25612;24207 pck2;orm1;kynu;insig1;gstp1;gpx1;gclm;gclc;cyp1b1;bhmt;asns;apoc3 PCK2_9440;ORM1_9400;KYNU_8979;INSIG1_8906;GSTP1_8762;GPX1_33050;GCLM_8700;GCLC_8699;CYP1B1_32710;BHMT_8143;ASNS_8091;APOC3_32553 126.47471166666666 69.01820000000001 2.87451 186.76864451072473 94.55474561592887 141.42544875049978 80.38166166666667 41.2507 1.13737 124.55286121374621 61.594508572736125 98.10882922507615 257.65785916666664 131.26049999999998 8.23841 393.39084438381957 182.73754767720936 281.6742354061425 6.67763;662.49;100.381;37.6554;122.514;8.00432;190.233;145.958;229.313;5.5396;6.05608;2.87451 1.48195;432.445;72.7231;13.2791;84.8469;2.69961;69.2223;96.7058;185.32;1.97501;2.7438;1.13737 37.9425;1413.32;161.456;101.065;216.573;25.2254;496.452;280.185;299.27;37.8319;14.3351;8.23841 8 4 8 361042;24614;64194;24426;29739;25283;25426;25612 PCK2_9440;ORM1_9400;INSIG1_8906;GSTP1_8762;GCLM_8700;GCLC_8699;CYP1B1_32710;ASNS_8091 175.11213874999999 134.236 213.86396584670004 110.75560625 77.03460000000001 143.79873833151677 357.392825 248.37900000000002 454.96157669622653 6.67763;662.49;37.6554;122.514;190.233;145.958;229.313;6.05608 1.48195;432.445;13.2791;84.8469;69.2223;96.7058;185.32;2.7438 37.9425;1413.32;101.065;216.573;496.452;280.185;299.27;14.3351 4 116682;24404;81508;24207 KYNU_8979;GPX1_33050;BHMT_8143;APOC3_32553 29.1998575 6.77196 47.50030723929153 19.6337725 2.33731 35.39864099299141 58.1879275 31.52865 69.90504314453304 100.381;8.00432;5.5396;2.87451 72.7231;2.69961;1.97501;1.13737 161.456;25.2254;37.8319;8.23841 0 Exp 4,2(0.17);Exp 5,1(0.09);Hill,4(0.34);Linear,2(0.17);Poly 2,3(0.25) 2.1283031773625587 27.88131010532379 1.5235437154769897 5.5128583908081055 1.195094053830622 1.8467147946357727 20.8004030259072 232.14902030742616 9.909246275574077 150.85407705775927 35.07603546296886 480.2396828703644 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0009410 4 response to xenobiotic stimulus 123 132 11 11 7 8 4 4 65 128 2350 0.71455 0.48451 0.78022 3.03 361042;24404;25283;25426 pck2;gpx1;gclc;cyp1b1 PCK2_9440;GPX1_33050;GCLC_8699;CYP1B1_32710 97.4882375 76.98116 6.67763 109.51563634272152 101.57892132068113 116.53385714012248 71.55184 49.702704999999995 1.48195 87.98927016792481 76.66525718087873 94.93443996926483 160.655725 159.06375 25.2254 149.3330431566833 159.31749937605613 150.1776988858408 6.67763;8.00432;145.958;229.313 1.48195;2.69961;96.7058;185.32 37.9425;25.2254;280.185;299.27 3 1 3 361042;25283;25426 PCK2_9440;GCLC_8699;CYP1B1_32710 127.31621 145.958 112.482284136491 94.50258333333333 96.7058 91.93882629069633 205.79916666666668 280.185 145.68100327284725 6.67763;145.958;229.313 1.48195;96.7058;185.32 37.9425;280.185;299.27 1 24404 GPX1_33050 8.00432 8.00432 2.69961 2.69961 25.2254 25.2254 8.00432 2.69961 25.2254 0 Hill,2(0.5);Linear,1(0.25);Poly 2,1(0.25) 1.9776308330656975 8.258376240730286 1.528982162475586 3.1843981742858887 0.7553754829817049 1.7724979519844055 -9.83708611586708 204.81356111586706 -14.677644764566338 157.78132476456634 14.309342706450366 307.0021072935496 UP 0.75 0.25 0.0 GO:0140352 4 export from cell 85 90 3 3 2 3 2 2 67 88 2390 0.55627 0.70942 1.0 2.22 266730;29200 slc17a3;inhba SLC17A3_9840;INHBA_33300 92.59715 92.59715 91.8104 1.1126325201970815 92.8146632352941 1.0692647520356593 56.5423 56.5423 44.1594 17.51206512150982 59.96580764705882 16.82948649249468 165.174 165.174 143.418 30.767630262988934 159.15910588235292 29.568381245969626 93.3839;91.8104 68.9252;44.1594 143.418;186.93 1 1 1 266730 SLC17A3_9840 93.3839 93.3839 68.9252 68.9252 143.418 143.418 93.3839 68.9252 143.418 1 29200 INHBA_33300 91.8104 91.8104 44.1594 44.1594 186.93 186.93 91.8104 44.1594 186.93 0 Hill,1(0.5);Poly 2,1(0.5) 1.857064833579272 3.7968326807022095 1.504341721534729 2.2924909591674805 0.5573056705171262 1.8984163403511047 91.05512 94.13918 32.27181599999999 80.81278400000001 122.53224000000002 207.81576 CONFLICT 0.5 0.5 0.0 GO:1901607 7 alpha-amino acid biosynthetic process 18 19 6 6 6 6 6 6 63 13 2465 1.0 6.5275E-6 6.5275E-6 31.58 287877;293820;58835;81508;25612;296925 pycr1;psat1;phgdh;bhmt;asns;aass PYCR1_9631;PSAT1_9583;PHGDH_9470;BHMT_8143;ASNS_8091;AASS_7936 50.00972333333333 16.60699 5.5396 60.860282073047834 60.25625413018106 66.53230258649344 29.22238333333333 6.3791 1.97501 39.32560140043769 37.35221151399072 43.67426311090553 109.40603333333333 70.85395 14.0792 108.70099752978658 120.73328744875057 118.69236022587701 0.0 5.5396 0.5 5.67518 132.668;27.1579;122.826;5.5396;6.05608;5.81076 90.3184;10.0144;67.6778;1.97501;2.7438;2.60489 239.858;103.876;246.456;37.8319;14.3351;14.0792 4 2 4 287877;293820;58835;25612 PYCR1_9631;PSAT1_9583;PHGDH_9470;ASNS_8091 72.176995 74.99195 64.8669862319714 42.6886 38.8461 43.0358314173976 151.131275 171.86700000000002 112.40624157567574 132.668;27.1579;122.826;6.05608 90.3184;10.0144;67.6778;2.7438 239.858;103.876;246.456;14.3351 2 81508;296925 BHMT_8143;AASS_7936 5.67518 5.67518 0.1917390747865672 2.28995 2.28995 0.4453924193337818 25.95555 25.95555 16.795695241489714 5.5396;5.81076 1.97501;2.60489 37.8319;14.0792 0 Exp 4,2(0.34);Hill,3(0.5);Poly 2,1(0.17) 2.1698717166845327 13.48714303970337 1.6724973917007446 3.5324413776397705 0.6989601022926415 2.071461498737335 1.3113553509316134 98.70809131573506 -2.2446513713229628 60.689418037989626 22.427120363359464 196.38494630330723 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0035690 5 cellular response to drug 160 174 16 16 10 10 5 5 64 169 2309 0.6688 0.5143 0.80869 2.87 361042;170496;29739;25283;25426 pck2;lcn2;gclm;gclc;cyp1b1 PCK2_9440;LCN2_32481;GCLM_8700;GCLC_8699;CYP1B1_32710 308.961526 190.233 6.67763 380.4065548525595 236.22097702800386 320.21267982714375 180.93221 96.7058 1.48195 217.6206233507707 145.7211664159149 185.6442703033093 1039.6839 299.27 37.9425 1709.8954218050296 706.1302858276277 1407.2682529924248 6.67763;972.626;190.233;145.958;229.313 1.48195;551.931;69.2223;96.7058;185.32 37.9425;4084.57;496.452;280.185;299.27 5 0 5 361042;170496;29739;25283;25426 PCK2_9440;LCN2_32481;GCLM_8700;GCLC_8699;CYP1B1_32710 308.961526 190.233 380.4065548525595 180.93221 96.7058 217.6206233507707 1039.6839 299.27 1709.8954218050296 6.67763;972.626;190.233;145.958;229.313 1.48195;551.931;69.2223;96.7058;185.32 37.9425;4084.57;496.452;280.185;299.27 0 0 Hill,2(0.4);Linear,2(0.4);Poly 2,1(0.2) 1.9793375990729825 10.239522099494934 1.528982162475586 3.1843981742858887 0.6518015669570948 1.856990933418274 -24.479520968835573 642.4025729688357 -9.820676790334886 371.6850967903349 -459.1055198481149 2538.473319848115 UP 1.0 0.0 0.0 GO:0097327 5 response to antineoplastic agent 75 80 8 8 5 6 3 3 66 77 2401 0.83072 0.36969 0.47696 3.75 361042;25426;25612 pck2;cyp1b1;asns PCK2_9440;CYP1B1_32710;ASNS_8091 80.68223666666667 6.67763 6.05608 128.71839199542399 102.2049151413793 135.0697308273499 63.181916666666666 2.7438 1.48195 105.77656459070144 80.62149646551724 111.25745891502395 117.18253333333332 37.9425 14.3351 158.13352418606036 146.7306611551724 162.37357695738825 6.67763;229.313;6.05608 1.48195;185.32;2.7438 37.9425;299.27;14.3351 3 0 3 361042;25426;25612 PCK2_9440;CYP1B1_32710;ASNS_8091 80.68223666666667 6.67763 128.71839199542399 63.181916666666666 2.7438 105.77656459070144 117.18253333333332 37.9425 158.13352418606036 6.67763;229.313;6.05608 1.48195;185.32;2.7438 37.9425;299.27;14.3351 0 0 Hill,2(0.67);Linear,1(0.34) 2.5812788092786225 8.245821714401245 1.528982162475586 3.5324413776397705 1.0704660254911604 3.1843981742858887 -64.97633593903242 226.34080927236573 -56.515534292508164 182.87936762584147 -61.762394869849885 296.12746153651653 UP 1.0 0.0 0.0 GO:0017182 9 peptidyl-diphthamide metabolic process 1 1 1 1 1 1 1 1 68 0 2478 1.0 0.027091 0.027091 100.0 298452 dph2 DPH2_8490 734.134 734.134 734.134 734.134 463.289 463.289 463.289 463.289 1764.85 1764.85 1764.85 1764.85 0.0 734.134 0.0 734.134 734.134 463.289 1764.85 0 1 0 1 298452 DPH2_8490 734.134 734.134 463.289 463.289 1764.85 1764.85 734.134 463.289 1764.85 0 Linear,1(1) 1.6845101118087769 1.6845101118087769 1.6845101118087769 1.6845101118087769 0.0 1.6845101118087769 734.134 734.134 463.289 463.289 1764.85 1764.85 DOWN 0.0 1.0 0.0 GO:0017183 9 peptidyl-diphthamide biosynthetic process from peptidyl-histidine 1 1 1 1 1 1 1 1 68 0 2478 1.0 0.027091 0.027091 100.0 298452 dph2 DPH2_8490 734.134 734.134 734.134 734.134 463.289 463.289 463.289 463.289 1764.85 1764.85 1764.85 1764.85 0.0 734.134 0.0 734.134 734.134 463.289 1764.85 0 1 0 1 298452 DPH2_8490 734.134 734.134 463.289 463.289 1764.85 1764.85 734.134 463.289 1764.85 0 Linear,1(1) 1.6845101118087769 1.6845101118087769 1.6845101118087769 1.6845101118087769 0.0 1.6845101118087769 734.134 734.134 463.289 463.289 1764.85 1764.85 DOWN 0.0 1.0 0.0 GO:0009719 3 response to endogenous stimulus 481 515 40 40 30 27 18 18 51 497 1981 0.91327 0.1411 0.22449 3.5 360243;361042;24614;24552;59107;64194;29200;25663;360504;24426;24404;29739;25283;24890;25315;25426;25612;24207 top2a;pck2;orm1;me1;ltbp1;insig1;inhba;il1r1;hba-a2;gstp1;gpx1;gclm;gclc;esr1;ephx1;cyp1b1;asns;apoc3 TOP2A_10059;PCK2_9440;ORM1_9400;ME1_9215;LTBP1_33264;INSIG1_8906;INHBA_33300;IL1R1_8893;HBA2_32600;GSTP1_8762;GPX1_33050;GCLM_8700;GCLC_8699;ESR1_33192;EPHX1_8567;CYP1B1_32710;ASNS_8091;APOC3_32553 140.77115222222247 57.1386 4.48597E-12 221.41051005393305 90.80495047659102 150.0574735869996 83.93161555555581 20.4003 4.48597E-12 136.92516718587783 55.46269043535044 97.60629149856284 326.21035611111137 143.10399999999998 4.48599E-12 573.2540058848311 192.17216939563292 358.9874025808265 4.48597E-12;6.67763;662.49;13.1175;769.394;37.6554;91.8104;76.6218;131.05;122.514;8.00432;190.233;145.958;12.5403;27.5708;229.313;6.05608;2.87451 4.48597E-12;1.48195;432.445;6.20444;438.027;13.2791;44.1594;27.5215;88.5948;84.8469;2.69961;69.2223;96.7058;3.74981;12.6303;185.32;2.7438;1.13737 4.48599E-12;37.9425;1413.32;28.4614;2211.2;101.065;186.93;185.143;254.163;216.573;25.2254;496.452;280.185;51.2968;61.9858;299.27;14.3351;8.23841 12 6 12 360243;361042;24614;24552;64194;25663;24426;29739;25283;25315;25426;25612 TOP2A_10059;PCK2_9440;ORM1_9400;ME1_9215;INSIG1_8906;IL1R1_8893;GSTP1_8762;GCLM_8700;GCLC_8699;EPHX1_8567;CYP1B1_32710;ASNS_8091 126.51726750000039 57.1386 185.9135553424258 77.7000908333337 20.4003 124.82306666075436 261.2277333333337 143.10399999999998 392.0596408679081 4.48597E-12;6.67763;662.49;13.1175;37.6554;76.6218;122.514;190.233;145.958;27.5708;229.313;6.05608 4.48597E-12;1.48195;432.445;6.20444;13.2791;27.5215;84.8469;69.2223;96.7058;12.6303;185.32;2.7438 4.48599E-12;37.9425;1413.32;28.4614;101.065;185.143;216.573;496.452;280.185;61.9858;299.27;14.3351 6 59107;29200;360504;24404;24890;24207 LTBP1_33264;INHBA_33300;HBA2_32600;GPX1_33050;ESR1_33192;APOC3_32553 169.27892166666666 52.17535 298.61944023485 96.39466499999999 23.954605 170.8436699800913 456.17560166666664 119.1134 865.2982805978589 769.394;91.8104;131.05;8.00432;12.5403;2.87451 438.027;44.1594;88.5948;2.69961;3.74981;1.13737 2211.2;186.93;254.163;25.2254;51.2968;8.23841 0 Exp 2,1(0.06);Exp 4,2(0.12);Exp 5,1(0.06);Hill,9(0.5);Linear,2(0.12);Poly 2,3(0.17) 2.1418596225498083 41.45010602474213 1.5140434503555298 5.5128583908081055 1.0383749708102348 1.8467147946357727 38.48471513995169 243.05758930449326 20.67541559049498 147.1878155206166 61.38051677414677 591.0401954480758 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0046394 6 carboxylic acid biosynthetic process 88 95 14 14 13 13 12 12 57 83 2395 1.0 5.4817E-6 5.4817E-6 12.63 83472;287877;293820;58835;24539;116682;84029;24426;24296;81508;25612;296925 ugdh;pycr1;psat1;phgdh;lpl;kynu;hao2;gstp1;cyp1a1;bhmt;asns;aass UGDH_10131;PYCR1_9631;PSAT1_9583;PHGDH_9470;LPL_32544;KYNU_8979;HAO2_8778;GSTP1_8762;CYP1A1_8415;BHMT_8143;ASNS_8091;AASS_7936 142.19440333333333 91.71015 5.5396 244.28996318261028 124.22931991548926 211.77593986605265 83.53008333333334 65.35245 1.97501 132.32387641886268 75.27898186220784 114.89272233101345 416.73535 148.262 14.0792 952.8104495711998 336.76777198765353 822.5230126674231 3.5 43.26205 8.5 127.747 59.3662;132.668;27.1579;122.826;900.118;100.381;140.856;122.514;83.0393;5.5396;6.05608;5.81076 25.4417;90.3184;10.0144;67.6778;487.466;72.7231;93.5219;84.8469;63.0271;1.97501;2.7438;2.60489 135.068;239.858;103.876;246.456;3428.38;161.456;282.925;216.573;119.986;37.8319;14.3351;14.0792 7 5 7 83472;287877;293820;58835;24426;24296;25612 UGDH_10131;PYCR1_9631;PSAT1_9583;PHGDH_9470;GSTP1_8762;CYP1A1_8415;ASNS_8091 79.08964 83.0393 50.17403925836415 49.15287142857143 63.0271 35.944802875135935 153.73601428571428 135.068 85.01830498762074 59.3662;132.668;27.1579;122.826;122.514;83.0393;6.05608 25.4417;90.3184;10.0144;67.6778;84.8469;63.0271;2.7438 135.068;239.858;103.876;246.456;216.573;119.986;14.3351 5 24539;116682;84029;81508;296925 LPL_32544;KYNU_8979;HAO2_8778;BHMT_8143;AASS_7936 230.54107199999999 100.381 378.961638733524 131.65818 72.7231 203.10059116178752 784.93442 161.456 1481.6311347622566 900.118;100.381;140.856;5.5396;5.81076 487.466;72.7231;93.5219;1.97501;2.60489 3428.38;161.456;282.925;37.8319;14.0792 0 Exp 2,1(0.09);Exp 4,2(0.17);Hill,4(0.34);Poly 2,5(0.42) 2.419786648104777 32.648178577423096 1.5737498998641968 6.292444229125977 1.5848691943810735 2.03916335105896 3.9743448496056146 280.4144618170611 8.6608021761011 158.39936449056557 -122.36791215568815 955.8386121556882 CONFLICT 0.5833333333333334 0.4166666666666667 0.0 GO:0015891 11 siderophore transport 1 1 1 1 1 1 1 1 68 0 2478 1.0 0.027091 0.027091 100.0 170496 lcn2 LCN2_32481 972.626 972.626 972.626 972.6259999999999 551.931 551.931 551.931 551.931 4084.57 4084.57 4084.57 4084.5700000000006 0.0 972.626 0.0 972.626 972.626 551.931 4084.57 1 0 1 170496 LCN2_32481 972.626 972.626 551.931 551.931 4084.57 4084.57 972.626 551.931 4084.57 0 0 Linear,1(1) 1.856990933418274 1.856990933418274 1.856990933418274 1.856990933418274 0.0 1.856990933418274 972.626 972.626 551.931 551.931 4084.57 4084.57 UP 1.0 0.0 0.0 GO:0006744 7 ubiquinone biosynthetic process 1 1 1 1 1 1 1 1 68 0 2478 1.0 0.027091 0.027091 100.0 360887 coq8a ADCK3_7987 525.072 525.072 525.072 525.072 336.426 336.426 336.426 336.426 1038.12 1038.12 1038.12 1038.12 0.0 525.072 0.0 525.072 525.072 336.426 1038.12 0 1 0 1 360887 ADCK3_7987 525.072 525.072 336.426 336.426 1038.12 1038.12 525.072 336.426 1038.12 0 Exp 2,1(1) 1.5869897603988647 1.5869897603988647 1.5869897603988647 1.5869897603988647 0.0 1.5869897603988647 525.072 525.072 336.426 336.426 1038.12 1038.12 DOWN 0.0 1.0 0.0 GO:0009605 3 response to external stimulus 571 616 44 44 34 29 20 20 49 596 1882 0.86075 0.209 0.39181 3.25 94195;361042;24614;59107;24539;170496;116682;360504;24426;116686;24404;29739;25283;25426;24296;310395;54232;25612;24207;114628 s100a9;pck2;orm1;ltbp1;lpl;lcn2;kynu;hba-a2;gstp1;gsr;gpx1;gclm;gclc;cyp1b1;cyp1a1;noct;car3;asns;apoc3;abcg5 S100A9_9775;PCK2_9440;ORM1_9400;LTBP1_33264;LPL_32544;LCN2_32481;KYNU_8979;HBA2_32600;GSTP1_8762;GSR_8755;GPX1_33050;GCLM_8700;GCLC_8699;CYP1B1_32710;CYP1A1_8415;CCRN4L_8232;CAR3_8196;ASNS_8091;APOC3_32553;ABCG5_7947 329.88435350000003 138.50400000000002 2.87451 360.1932661934551 258.80917645439087 312.58862301892503 212.21423800000002 86.72085000000001 1.13737 237.98593179999256 167.1220695400691 199.61384715868522 840.6814770000001 267.174 6.02113 1175.3274257950463 635.9157614495457 1024.5814217067066 963.318;6.67763;662.49;769.394;900.118;972.626;100.381;131.05;122.514;69.5519;8.00432;190.233;145.958;229.313;83.0393;665.276;3.44933;6.05608;2.87451;565.363 802.143;1.48195;432.445;438.027;487.466;551.931;72.7231;88.5948;84.8469;41.1016;2.69961;69.2223;96.7058;185.32;63.0271;433.686;2.13143;2.7438;1.13737;386.851 1158.68;37.9425;1413.32;2211.2;3428.38;4084.57;161.456;254.163;216.573;124.212;25.2254;496.452;280.185;299.27;119.986;1425.48;6.02113;14.3351;8.23841;1047.94 12 8 12 94195;361042;24614;170496;24426;116686;29739;25283;25426;24296;310395;25612 S100A9_9775;PCK2_9440;ORM1_9400;LCN2_32481;GSTP1_8762;GSR_8755;GCLM_8700;GCLC_8699;CYP1B1_32710;CYP1A1_8415;CCRN4L_8232;ASNS_8091 343.08774250000005 168.09550000000002 366.78683378701373 230.38787083333332 90.77635000000001 260.6928377834295 805.9171333333334 289.72749999999996 1158.1566066106025 963.318;6.67763;662.49;972.626;122.514;69.5519;190.233;145.958;229.313;83.0393;665.276;6.05608 802.143;1.48195;432.445;551.931;84.8469;41.1016;69.2223;96.7058;185.32;63.0271;433.686;2.7438 1158.68;37.9425;1413.32;4084.57;216.573;124.212;496.452;280.185;299.27;119.986;1425.48;14.3351 8 59107;24539;116682;360504;24404;54232;24207;114628 LTBP1_33264;LPL_32544;KYNU_8979;HBA2_32600;GPX1_33050;CAR3_8196;APOC3_32553;ABCG5_7947 310.07927 115.7155 374.1573983048899 184.95378875 80.65895 213.35149758801015 892.8279924999999 207.8095 1279.2657398000579 769.394;900.118;100.381;131.05;8.00432;3.44933;2.87451;565.363 438.027;487.466;72.7231;88.5948;2.69961;2.13143;1.13737;386.851 2211.2;3428.38;161.456;254.163;25.2254;6.02113;8.23841;1047.94 0 Exp 2,2(0.1);Exp 4,3(0.15);Hill,4(0.2);Linear,5(0.25);Poly 2,6(0.3) 2.2398414999434437 51.37590003013611 1.5140434503555298 6.759152412414551 1.6549184724451658 1.798611342906952 172.02269436373646 487.7460126362636 107.91230464609123 316.5161713539088 325.5715211000776 1355.7914328999223 UP 0.6 0.4 0.0 GO:0048646 3 anatomical structure formation involved in morphogenesis 166 174 4 4 4 4 4 4 65 170 2308 0.4857 0.70561 1.0 2.3 29200;24404;25317;25426 inhba;gpx1;fgf1;cyp1b1 INHBA_33300;GPX1_33050;FGF1_8633;CYP1B1_32710 250.82243 160.5617 8.00432 296.60552216448633 286.45851656089195 295.7710531992296 167.4502525 114.7397 2.69961 196.34621593608324 196.09366787342765 192.75767087301261 494.10635 243.1 25.2254 656.9633014011945 551.4152642867352 669.4136054475935 91.8104;8.00432;674.162;229.313 44.1594;2.69961;437.622;185.32 186.93;25.2254;1465.0;299.27 2 2 2 25317;25426 FGF1_8633;CYP1B1_32710 451.7375 451.7375 314.55574450405453 311.471 311.471 178.40445510692828 882.135 882.135 824.295588032594 674.162;229.313 437.622;185.32 1465.0;299.27 2 29200;24404 INHBA_33300;GPX1_33050 49.90736 49.90736 59.2598474726623 23.429505 23.429505 29.316498655570207 106.07770000000001 106.07770000000001 114.34241920905819 91.8104;8.00432 44.1594;2.69961 186.93;25.2254 0 Hill,2(0.5);Linear,2(0.5) 2.1267909090205843 8.831940650939941 1.5704141855239868 3.1843981742858887 0.7179237971535417 2.038564145565033 -39.850981721196604 541.4958417211966 -24.969039117361575 359.86954411736156 -149.71768537317058 1137.9303853731706 CONFLICT 0.5 0.5 0.0 GO:0051345 6 positive regulation of hydrolase activity 168 180 6 6 5 3 2 2 67 178 2300 0.12263 0.96207 0.23265 1.11 94195;24890 s100a9;esr1 S100A9_9775;ESR1_33192 487.92915 487.92915 12.5403 672.3013590709488 215.03151150550795 550.493301700306 402.946405 402.946405 3.74981 564.5492387021596 173.78703773561813 462.26379017738816 604.9884000000001 604.9884000000001 51.2968 783.0381700920587 287.14095764993885 641.1667354161233 963.318;12.5403 802.143;3.74981 1158.68;51.2968 1 1 1 94195 S100A9_9775 963.318 963.318 802.143 802.143 1158.68 1158.68 963.318 802.143 1158.68 1 24890 ESR1_33192 12.5403 12.5403 3.74981 3.74981 51.2968 51.2968 12.5403 3.74981 51.2968 0 Hill,1(0.5);Poly 2,1(0.5) 1.7186962605467095 3.437492609024048 1.7056305408477783 1.7318620681762695 0.018548490854856377 1.718746304512024 -443.8329959999999 1419.691296 -379.47892119999995 1185.3717311999999 -480.2471359999996 1690.2239359999999 CONFLICT 0.5 0.5 0.0 GO:0002544 6 chronic inflammatory response 13 14 4 4 3 3 2 2 67 12 2466 0.99441 0.053364 0.053364 14.29 94195;24614 s100a9;orm1 S100A9_9775;ORM1_9400 812.904 812.904 662.49 212.71751877078685 793.8097992975414 210.9966013732648 617.294 617.294 432.445 261.41596279110445 593.8284721525339 259.3010675020057 1286.0 1286.0 1158.68 180.05767076134248 1302.1625489212242 178.60097655035105 0.0 662.49 0.5 812.904 963.318;662.49 802.143;432.445 1158.68;1413.32 2 0 2 94195;24614 S100A9_9775;ORM1_9400 812.904 812.904 212.71751877078685 617.294 617.294 261.41596279110445 1286.0 1286.0 180.05767076134248 963.318;662.49 802.143;432.445 1158.68;1413.32 0 0 Linear,1(0.5);Poly 2,1(0.5) 1.6253158128773317 3.2544134855270386 1.5487829446792603 1.7056305408477783 0.11090799886356828 1.6272067427635193 518.09256 1107.71544 254.98996 979.59804 1036.4528000000003 1535.5471999999997 UP 1.0 0.0 0.0 GO:0001682 11 tRNA 5'-leader removal 2 2 1 1 1 1 1 1 68 1 2477 0.99928 0.053458 0.053458 50.0 291317 rpp38 RPP38_9741 916.962 916.962 916.962 916.9620000000001 769.912 769.912 769.912 769.912 1051.72 1051.72 1051.72 1051.72 0.0 916.962 0.0 916.962 916.962 769.912 1051.72 0 1 0 1 291317 RPP38_9741 916.962 916.962 769.912 769.912 1051.72 1051.72 916.962 769.912 1051.72 0 Poly 2,1(1) 1.5943320989608765 1.5943320989608765 1.5943320989608765 1.5943320989608765 0.0 1.5943320989608765 916.962 916.962 769.912 769.912 1051.72 1051.72 DOWN 0.0 1.0 0.0 GO:0051234 3 establishment of localization 596 632 25 24 21 14 10 10 59 622 1856 0.025987 0.98818 0.047414 1.58 266730;287167;170496;293502;29200;360504;24207;301111;25748;114628 slc17a3;hba-a1;lcn2;kif22;inhba;hba-a2;apoc3;ano10;alas2;abcg5 SLC17A3_9840;LOC287167_9118;LCN2_32481;KIF22_8963;INHBA_33300;HBA2_32600;APOC3_32553;ANO10_8049;ALAS2_8019;ABCG5_7947 214.2778366 109.44495 0.961856 312.5086718291549 204.13704559273862 290.21263543824966 132.7590341 77.35795 0.281971 185.40079015277271 130.54504533526273 178.98730014058896 633.3834380000001 211.846 4.47267 1249.8514602653634 533.1422063065421 1049.3541841845945 93.3839;149.282;972.626;0.961856;91.8104;131.05;2.87451;9.9207;125.506;565.363 68.9252;97.0024;551.931;0.281971;44.1594;88.5948;1.13737;2.9165;85.7907;386.851 143.418;334.152;4084.57;4.47267;186.93;254.163;8.23841;33.1883;236.762;1047.94 4 6 4 266730;170496;293502;301111 SLC17A3_9840;LCN2_32481;KIF22_8963;ANO10_8049 269.223114 51.6523 470.7783957317344 156.01366775000002 35.92085 265.8483523469131 1066.4122425 88.30315 2012.9962735387187 93.3839;972.626;0.961856;9.9207 68.9252;551.931;0.281971;2.9165 143.418;4084.57;4.47267;33.1883 6 287167;29200;360504;24207;25748;114628 LOC287167_9118;INHBA_33300;HBA2_32600;APOC3_32553;ALAS2_8019;ABCG5_7947 177.64765166666666 128.27800000000002 196.94241763968077 117.255945 87.19275 136.91592383072816 344.6975683333333 245.4625 361.27637413117674 149.282;91.8104;131.05;2.87451;125.506;565.363 97.0024;44.1594;88.5948;1.13737;85.7907;386.851 334.152;186.93;254.163;8.23841;236.762;1047.94 0 Exp 4,2(0.2);Hill,2(0.2);Linear,2(0.2);Poly 2,4(0.4) 1.7925363239698633 18.078222632408142 1.504341721534729 2.2924909591674805 0.2520855945861917 1.771103858947754 20.582955059291407 407.97271814070865 17.846433831974963 247.67163436802505 -141.28252285989277 1408.0493988598932 DOWN 0.4 0.6 0.0 GO:0072521 5 purine-containing compound metabolic process 83 95 5 5 5 3 3 3 66 92 2386 0.74496 0.47958 0.74206 3.16 266730;116682;296925 slc17a3;kynu;aass SLC17A3_9840;KYNU_8979;AASS_7936 66.52522 93.3839 5.81076 52.6965282719953 58.41133603006491 54.59363969915302 48.08439666666667 68.9252 2.60489 39.43215890722993 42.105634673727366 40.96423817618388 106.31773333333335 143.418 14.0792 80.38844839038337 93.48226416125725 82.67903256614287 93.3839;100.381;5.81076 68.9252;72.7231;2.60489 143.418;161.456;14.0792 1 2 1 266730 SLC17A3_9840 93.3839 93.3839 68.9252 68.9252 143.418 143.418 93.3839 68.9252 143.418 2 116682;296925 KYNU_8979;AASS_7936 53.09588 53.09588 66.87125800243928 37.663995 37.663995 49.58106177566239 87.76759999999999 87.76759999999999 104.21113466957358 100.381;5.81076 72.7231;2.60489 161.456;14.0792 0 Hill,1(0.34);Poly 2,2(0.67) 1.9042942964486815 5.806905150413513 1.504341721534729 2.3450815677642822 0.42079547837626624 1.957481861114502 6.893484624937379 126.15695537506264 3.462708249424736 92.70608508390859 15.349640390201927 197.28582627646475 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0071333 8 cellular response to glucose stimulus 51 54 9 9 8 7 6 6 63 48 2430 0.99949 0.0029399 0.0029399 11.11 361042;25663;24404;29739;25283;24207 pck2;il1r1;gpx1;gclm;gclc;apoc3 PCK2_9440;IL1R1_8893;GPX1_33050;GCLM_8700;GCLC_8699;APOC3_32553 71.72821 42.31305999999999 2.87451 80.7595670100265 54.44814050122159 77.05285624295047 33.12808833333333 15.110555 1.13737 40.80962581040087 24.89252641741319 38.38509055456276 172.19771833333334 111.54275 8.23841 191.56077536567972 133.79974969694726 181.47572941996793 1.5 7.340975 4.5 168.09550000000002 6.67763;76.6218;8.00432;190.233;145.958;2.87451 1.48195;27.5215;2.69961;69.2223;96.7058;1.13737 37.9425;185.143;25.2254;496.452;280.185;8.23841 4 2 4 361042;25663;29739;25283 PCK2_9440;IL1R1_8893;GCLM_8700;GCLC_8699 104.8726075 111.28989999999999 80.44618867139424 48.732887500000004 48.371900000000004 42.441294406241795 249.930625 232.664 192.20173172363067 6.67763;76.6218;190.233;145.958 1.48195;27.5215;69.2223;96.7058 37.9425;185.143;496.452;280.185 2 24404;24207 GPX1_33050;APOC3_32553 5.439415 5.439415 3.627323437198562 1.9184899999999998 1.9184899999999998 1.1046704978408723 16.731905 16.731905 12.011615820948068 8.00432;2.87451 2.69961;1.13737 25.2254;8.23841 0 Exp 4,1(0.17);Hill,4(0.67);Poly 2,1(0.17) 1.6942511412581283 10.199480295181274 1.5235437154769897 1.90879225730896 0.15154630845385234 1.7267624139785767 7.107097865927571 136.3493221340724 0.4735867890637877 65.78258987760287 18.917174569910486 325.4782620967561 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0006090 8 pyruvate metabolic process 20 25 2 2 2 2 2 2 67 23 2455 0.97143 0.14577 0.14577 8.0 361042;24552 pck2;me1 PCK2_9440;ME1_9215 9.897565 9.897565 6.67763 4.55367574695981 8.94678845455741 4.350633371099264 3.843195 3.843195 1.48195 3.339304703085659 3.145970874654742 3.1904095251429836 33.201950000000004 33.201950000000004 28.4614 6.704150103107769 34.601730974615286 6.405220921343017 0.5 9.897565 6.67763;13.1175 1.48195;6.20444 37.9425;28.4614 2 0 2 361042;24552 PCK2_9440;ME1_9215 9.897565 9.897565 4.55367574695981 3.843195 3.843195 3.339304703085659 33.201950000000004 33.201950000000004 6.704150103107769 6.67763;13.1175 1.48195;6.20444 37.9425;28.4614 0 0 Exp 4,1(0.5);Hill,1(0.5) 2.2034122094989743 4.7043137550354 1.528982162475586 3.1753315925598145 1.1641448462151658 2.3521568775177 3.586492400000001 16.2086376 -0.7848451999999995 8.471235199999999 23.910472000000002 42.49342800000001 UP 1.0 0.0 0.0 GO:0032269 7 negative regulation of cellular protein metabolic process 274 292 15 15 12 8 5 5 64 287 2191 0.1793 0.91185 0.33897 1.71 299270;288001;24426;24404;25283 serpina6;kng1;gstp1;gpx1;gclc SERPINA6_32325;KNG1L1_32433;GSTP1_8762;GPX1_33050;GCLC_8699 288001(0.1788) 61.22527600000001 25.7745 3.87556 67.66490931022724 49.284664605672624 65.05796254651639 38.736228 8.17372 1.25511 47.76035041960193 29.612878151507072 45.379459371085346 127.81896000000002 103.274 13.8374 117.48657305891597 111.34420906908508 116.17226344823912 25.7745;3.87556;122.514;8.00432;145.958 8.17372;1.25511;84.8469;2.69961;96.7058 103.274;13.8374;216.573;25.2254;280.185 3 2 3 288001;24426;25283 KNG1L1_32433;GSTP1_8762;GCLC_8699 90.78251999999999 122.514 76.17099222362278 60.93593666666667 84.8469 52.024121146012966 170.1984666666667 216.573 139.09783971310742 3.87556;122.514;145.958 1.25511;84.8469;96.7058 13.8374;216.573;280.185 2 299270;24404 SERPINA6_32325;GPX1_33050 16.889409999999998 16.889409999999998 12.565414780905565 5.436665 5.436665 3.8707803019610916 64.2497 64.2497 55.18869432211636 25.7745;8.00432 8.17372;2.69961 103.274;25.2254 0 Exp 4,1(0.2);Hill,2(0.4);Poly 2,2(0.4) 2.2297250028354596 12.6531423330307 1.5755720138549805 5.5128583908081055 1.674565477657062 1.7846373319625854 1.9143679316615874 120.53618406833841 -3.127564945636678 80.60002094563667 24.837438189133266 230.80048181086676 UP 0.6 0.4 0.0 GO:0051707 4 response to other organism 231 253 14 14 11 10 7 7 62 246 2232 0.62231 0.53679 0.84026 2.77 94195;24539;170496;360504;24404;24296;54232 s100a9;lpl;lcn2;hba-a2;gpx1;cyp1a1;car3 S100A9_9775;LPL_32544;LCN2_32481;HBA2_32600;GPX1_33050;CYP1A1_8415;CAR3_8196 437.3721357142857 131.05 3.44933 477.71683001712637 312.1405606232017 429.03289586087715 285.42756285714285 88.5948 2.13143 323.3252623663126 194.35539373298136 265.79323447303386 1296.717932857143 254.163 6.02113 1736.345161324188 1007.6544563654973 1661.4568650814251 963.318;900.118;972.626;131.05;8.00432;83.0393;3.44933 802.143;487.466;551.931;88.5948;2.69961;63.0271;2.13143 1158.68;3428.38;4084.57;254.163;25.2254;119.986;6.02113 3 4 3 94195;170496;24296 S100A9_9775;LCN2_32481;CYP1A1_8415 672.9944333333333 963.318 510.93732905882234 472.3670333333334 551.931 375.9267175953358 1787.7453333333335 1158.68 2055.7903512920116 963.318;972.626;83.0393 802.143;551.931;63.0271 1158.68;4084.57;119.986 4 24539;360504;24404;54232 LPL_32544;HBA2_32600;GPX1_33050;CAR3_8196 260.6554125 69.52716000000001 430.38645702745293 145.22296 45.647205 231.75068370009944 928.4473825 139.6942 1670.42935214236 900.118;131.05;8.00432;3.44933 487.466;88.5948;2.69961;2.13143 3428.38;254.163;25.2254;6.02113 0 Exp 2,1(0.15);Exp 4,1(0.15);Hill,1(0.15);Linear,1(0.15);Poly 2,3(0.43) 2.5975389396836404 22.050544023513794 1.7036563158035278 6.759152412414551 2.3115602279249434 1.856990933418274 83.4745555003646 791.2697159282068 45.90485655147015 524.9502691628156 10.41543648758693 2583.020429226699 CONFLICT 0.42857142857142855 0.5714285714285714 0.0 GO:0030334 6 regulation of cell migration 259 272 9 9 7 5 4 4 65 268 2210 0.12412 0.94766 0.23548 1.47 25663;24426;25317;25426 il1r1;gstp1;fgf1;cyp1b1 IL1R1_8893;GSTP1_8762;FGF1_8633;CYP1B1_32710 275.6527 175.9135 76.6218 273.2653109922541 339.82302262917483 278.5704609384361 183.82760000000002 135.08345 27.5215 181.33082161142192 231.7567407786112 179.9053501836229 541.4965 257.9215 185.143 617.547701161349 656.1919919540711 656.4673599761609 76.6218;122.514;674.162;229.313 27.5215;84.8469;437.622;185.32 185.143;216.573;1465.0;299.27 4 0 4 25663;24426;25317;25426 IL1R1_8893;GSTP1_8762;FGF1_8633;CYP1B1_32710 275.6527 175.9135 273.2653109922541 183.82760000000002 135.08345 181.33082161142192 541.4965 257.9215 617.547701161349 76.6218;122.514;674.162;229.313 27.5215;84.8469;437.622;185.32 185.143;216.573;1465.0;299.27 0 0 Hill,1(0.25);Linear,2(0.5);Poly 2,1(0.25) 2.6138430368037624 11.960837006568909 1.5704141855239868 5.5128583908081055 1.8348121229395133 2.438782215118408 7.852695227590971 543.452704772409 6.123394820806482 361.53180517919355 -63.70024713812188 1146.693247138122 UP 1.0 0.0 0.0 GO:0007568 3 aging 181 193 15 15 12 9 7 7 62 186 2292 0.85269 0.26529 0.35979 3.63 360243;116682;116686;24404;29739;25283;24296 top2a;kynu;gsr;gpx1;gclm;gclc;cyp1a1 TOP2A_10059;KYNU_8979;GSR_8755;GPX1_33050;GCLM_8700;GCLC_8699;CYP1A1_8415 85.30964571428636 83.0393 4.48597E-12 68.82536950800797 82.20432402392585 64.98097882313485 49.354215714286354 63.0271 4.48597E-12 36.630047625448896 48.88876779787494 34.96269966341605 172.5023428571435 124.212 4.48599E-12 169.9011655697392 161.46747933466835 160.1929768013189 4.48597E-12;100.381;69.5519;8.00432;190.233;145.958;83.0393 4.48597E-12;72.7231;41.1016;2.69961;69.2223;96.7058;63.0271 4.48599E-12;161.456;124.212;25.2254;496.452;280.185;119.986 5 2 5 360243;116686;29739;25283;24296 TOP2A_10059;GSR_8755;GCLM_8700;GCLC_8699;CYP1A1_8415 97.7564400000009 83.0393 73.21836583762833 54.0113600000009 63.0271 36.12257044650725 204.16700000000088 124.212 191.29340306450595 4.48597E-12;69.5519;190.233;145.958;83.0393 4.48597E-12;41.1016;69.2223;96.7058;63.0271 4.48599E-12;124.212;496.452;280.185;119.986 2 116682;24404 KYNU_8979;GPX1_33050 54.192660000000004 54.192660000000004 65.32017685149971 37.711355 37.711355 49.5140846213484 93.3407 93.3407 96.32958106511208 100.381;8.00432 72.7231;2.69961 161.456;25.2254 0 Exp 4,1(0.15);Hill,3(0.43);Poly 2,3(0.43) 2.1809335956454183 17.269258499145508 1.75295889377594 6.292444229125977 1.6886040737554318 1.8125853538513184 34.3230984633976 136.29619296517512 22.218296686057208 76.4901347425155 46.63779802103241 298.3668876932546 UP 0.7142857142857143 0.2857142857142857 0.0 GO:0032787 7 monocarboxylic acid metabolic process 180 207 22 22 18 18 14 14 55 193 2285 0.99971 9.7454E-4 9.7454E-4 6.76 58835;361042;24552;24539;116682;84029;24426;24404;25315;171142;25426;24296;290277;25612 phgdh;pck2;me1;lpl;kynu;hao2;gstp1;gpx1;ephx1;ehhadh;cyp1b1;cyp1a1;cryl1;asns PHGDH_9470;PCK2_9440;ME1_9215;LPL_32544;KYNU_8979;HAO2_8778;GSTP1_8762;GPX1_33050;EPHX1_8567;EHHADH_8534;CYP1B1_32710;CYP1A1_8415;CRYL1_8388;ASNS_8091 140.01240928571428 91.71015 6.05608 229.59247361320124 119.56323589041415 187.23031869642242 85.78922142857144 65.35245 1.48195 127.17326538298714 76.67672128482775 108.1639536663107 384.4483 140.721 14.3351 884.1669108803696 292.09432474763355 696.8354821215967 9.5 131.841 122.826;6.67763;13.1175;900.118;100.381;140.856;122.514;8.00432;27.5708;166.899;229.313;83.0393;32.8011;6.05608 67.6778;1.48195;6.20444;487.466;72.7231;93.5219;84.8469;2.69961;12.6303;105.26;185.32;63.0271;15.4462;2.7438 246.456;37.9425;28.4614;3428.38;161.456;282.925;216.573;25.2254;61.9858;384.658;299.27;119.986;74.622;14.3351 9 5 9 58835;361042;24552;24426;25315;25426;24296;290277;25612 PHGDH_9470;PCK2_9440;ME1_9215;GSTP1_8762;EPHX1_8567;CYP1B1_32710;CYP1A1_8415;CRYL1_8388;ASNS_8091 71.54615666666666 32.8011 75.49470826573906 48.819832222222225 15.4462 60.30251226679196 122.18131111111113 74.622 105.54324011476817 122.826;6.67763;13.1175;122.514;27.5708;229.313;83.0393;32.8011;6.05608 67.6778;1.48195;6.20444;84.8469;12.6303;185.32;63.0271;15.4462;2.7438 246.456;37.9425;28.4614;216.573;61.9858;299.27;119.986;74.622;14.3351 5 24539;116682;84029;24404;171142 LPL_32544;KYNU_8979;HAO2_8778;GPX1_33050;EHHADH_8534 263.251664 140.856 361.0890901726394 152.334122 93.5219 191.51803314297698 856.5288800000001 282.925 1443.978315830945 900.118;100.381;140.856;8.00432;166.899 487.466;72.7231;93.5219;2.69961;105.26 3428.38;161.456;282.925;25.2254;384.658 0 Exp 2,1(0.08);Exp 4,2(0.15);Hill,5(0.36);Linear,1(0.08);Poly 2,5(0.36) 2.5684342796025237 39.90635812282562 1.5039241313934326 6.292444229125977 1.4712838948972162 2.420735716819763 19.74451680775931 260.2803017636693 19.1717911337131 152.40665172342975 -78.70665145312842 847.6032514531286 UP 0.6428571428571429 0.35714285714285715 0.0 GO:1903530 5 regulation of secretion by cell 205 222 8 8 7 5 4 4 65 218 2260 0.26731 0.86554 0.51672 1.8 361042;24614;24539;29200 pck2;orm1;lpl;inhba PCK2_9440;ORM1_9400;LPL_32544;INHBA_33300 415.27400750000004 377.1502 6.67763 435.0360709543278 261.9645119742985 417.76563187798337 241.38808749999998 238.3022 1.48195 253.97584715712105 147.95210553687062 239.67628555149315 1266.643125 800.125 37.9425 1567.3870060887098 844.6443863259876 1492.403868205466 6.67763;662.49;900.118;91.8104 1.48195;432.445;487.466;44.1594 37.9425;1413.32;3428.38;186.93 2 2 2 361042;24614 PCK2_9440;ORM1_9400 334.583815 334.583815 463.72937401302113 216.963475 216.963475 304.73689509583716 725.63125 725.63125 972.5387569414006 6.67763;662.49 1.48195;432.445 37.9425;1413.32 2 24539;29200 LPL_32544;INHBA_33300 495.9642 495.9642 571.5597852446235 265.8127 265.8127 313.4651030047524 1807.655 1807.655 2292.0512758771342 900.118;91.8104 487.466;44.1594 3428.38;186.93 0 Exp 2,1(0.25);Hill,2(0.5);Linear,1(0.25) 1.7438962705145555 7.0739123821258545 1.528982162475586 2.2924909591674805 0.3579644328893555 1.626219630241394 -11.061342035241182 841.6093570352411 -7.508242713978575 490.2844177139786 -269.3961409669355 2802.6823909669356 CONFLICT 0.5 0.5 0.0 GO:0001932 8 regulation of protein phosphorylation 371 395 17 17 14 6 4 4 65 391 2087 0.01161 0.99661 0.026478 1.01 29200;24426;25317;24890 inhba;gstp1;fgf1;esr1 INHBA_33300;GSTP1_8762;FGF1_8633;ESR1_33192 225.256675 107.1622 12.5403 302.83560588985546 299.0988674366993 353.27046187023154 142.5945275 64.50315 3.74981 199.45202256450304 189.83810586099062 233.2480746593159 479.94995 201.75150000000002 51.2968 660.6298088186328 651.7183472712601 763.9069796716851 91.8104;122.514;674.162;12.5403 44.1594;84.8469;437.622;3.74981 186.93;216.573;1465.0;51.2968 2 2 2 24426;25317 GSTP1_8762;FGF1_8633 398.338 398.338 390.07404162799656 261.23445000000004 261.23445000000004 249.44966544376237 840.7865 840.7865 882.7711975163779 122.514;674.162 84.8469;437.622 216.573;1465.0 2 29200;24890 INHBA_33300;ESR1_33192 52.17535 52.17535 56.052425255335734 23.954605 23.954605 28.573895113968096 119.1134 119.1134 95.90715547403126 91.8104;12.5403 44.1594;3.74981 186.93;51.2968 0 Hill,2(0.5);Linear,1(0.25);Poly 2,1(0.25) 2.4213244897241366 11.107625603675842 1.5704141855239868 5.5128583908081055 1.8500299758284946 2.012176513671875 -71.5222187720583 522.0355687720584 -52.868454613212975 338.05750961321297 -167.4672626422601 1127.3671626422602 CONFLICT 0.5 0.5 0.0 GO:0010604 6 positive regulation of macromolecule metabolic process 704 754 34 34 28 21 16 16 53 738 1740 0.14638 0.90863 0.28495 2.12 360243;94195;24614;259241;316351;24539;170496;64194;29200;25663;25283;25317;24890;24309;25426;310395 top2a;s100a9;orm1;nr1d2;npas2;lpl;lcn2;insig1;inhba;il1r1;gclc;fgf1;esr1;dbp;cyp1b1;noct TOP2A_10059;S100A9_9775;ORM1_9400;NR1D2_9358;NPAS2_9350;LPL_32544;LCN2_32481;INSIG1_8906;INHBA_33300;IL1R1_8893;GCLC_8699;FGF1_8633;ESR1_33192;DBP_8439;CYP1B1_32710;CCRN4L_8232 347.52427562500026 118.88419999999999 4.48597E-12 381.64800330805434 283.6225408197643 341.25884388079345 222.03839437500028 70.4326 4.48597E-12 259.5736929462352 178.22907686146195 220.6416812463391 914.0199625000002 280.3065 4.48599E-12 1237.3713248534511 746.9702451945855 1113.2115912957397 4.48597E-12;963.318;662.49;9.46041;53.0014;900.118;972.626;37.6554;91.8104;76.6218;145.958;674.162;12.5403;66.0377;229.313;665.276 4.48597E-12;802.143;432.445;2.2133;14.3825;487.466;551.931;13.2791;44.1594;27.5215;96.7058;437.622;3.74981;19.9899;185.32;433.686 4.48599E-12;1158.68;1413.32;49.4216;215.15;3428.38;4084.57;101.065;186.93;185.143;280.185;1465.0;51.2968;280.428;299.27;1425.48 12 4 12 360243;94195;24614;259241;170496;64194;25663;25283;25317;24309;25426;310395 TOP2A_10059;S100A9_9775;ORM1_9400;NR1D2_9358;LCN2_32481;INSIG1_8906;IL1R1_8893;GCLC_8699;FGF1_8633;DBP_8439;CYP1B1_32710;CCRN4L_8232 375.24319250000036 187.63549999999998 382.0876288836169 250.23805000000038 141.0129 271.0704801192634 895.2135500000004 289.849 1163.0170822002854 4.48597E-12;963.318;662.49;9.46041;972.626;37.6554;76.6218;145.958;674.162;66.0377;229.313;665.276 4.48597E-12;802.143;432.445;2.2133;551.931;13.2791;27.5215;96.7058;437.622;19.9899;185.32;433.686 4.48599E-12;1158.68;1413.32;49.4216;4084.57;101.065;185.143;280.185;1465.0;280.428;299.27;1425.48 4 316351;24539;29200;24890 NPAS2_9350;LPL_32544;INHBA_33300;ESR1_33192 264.367525 72.4059 425.0675310660286 137.4394275 29.27095 233.97698335486984 970.4392 201.04000000000002 1640.1874049331152 53.0014;900.118;91.8104;12.5403 14.3825;487.466;44.1594;3.74981 215.15;3428.38;186.93;51.2968 0 Exp 2,1(0.07);Exp 4,1(0.07);Exp 5,1(0.07);Hill,6(0.38);Linear,5(0.32);Poly 2,2(0.13) 1.915255912695733 31.2456716299057 1.5487829446792603 3.1843981742858887 0.4345387939377386 1.7589349150657654 160.51675400405372 534.5317972459469 94.84728483134505 349.2295039186555 307.7080133218094 1520.3319116781913 UP 0.75 0.25 0.0 GO:0006065 6 UDP-glucuronate biosynthetic process 1 1 1 1 1 1 1 1 68 0 2478 1.0 0.027091 0.027091 100.0 83472 ugdh UGDH_10131 59.3662 59.3662 59.3662 59.3662 25.4417 25.4417 25.4417 25.4417 135.068 135.068 135.068 135.068 0.0 59.3662 0.0 59.3662 59.3662 25.4417 135.068 1 0 1 83472 UGDH_10131 59.3662 59.3662 25.4417 25.4417 135.068 135.068 59.3662 25.4417 135.068 0 0 Hill,1(1) 1.5737498998641968 1.5737498998641968 1.5737498998641968 1.5737498998641968 0.0 1.5737498998641968 59.3662 59.3662 25.4417 25.4417 135.068 135.068 UP 1.0 0.0 0.0 GO:0046398 6 UDP-glucuronate metabolic process 1 1 1 1 1 1 1 1 68 0 2478 1.0 0.027091 0.027091 100.0 83472 ugdh UGDH_10131 59.3662 59.3662 59.3662 59.3662 25.4417 25.4417 25.4417 25.4417 135.068 135.068 135.068 135.068 0.0 59.3662 0.0 59.3662 59.3662 25.4417 135.068 1 0 1 83472 UGDH_10131 59.3662 59.3662 25.4417 25.4417 135.068 135.068 59.3662 25.4417 135.068 0 0 Hill,1(1) 1.5737498998641968 1.5737498998641968 1.5737498998641968 1.5737498998641968 0.0 1.5737498998641968 59.3662 59.3662 25.4417 25.4417 135.068 135.068 UP 1.0 0.0 0.0 GO:0051093 5 negative regulation of developmental process 252 270 14 14 12 7 5 5 64 265 2213 0.24368 0.8717 0.43295 1.85 192247;64194;29200;84586;310395 sez6;insig1;inhba;fgl2;noct SEZ6_9819;INSIG1_8906;INHBA_33300;FGL2_32918;CCRN4L_8232 190.3574 91.8104 10.6392 270.55842511930757 234.77156840831893 315.08997422006314 118.140114 44.1594 3.96047 179.98786716573835 146.4751264220909 210.02045206892342 413.61314000000004 186.93 29.4997 576.2650067900166 508.3537849485879 670.7777463121226 10.6392;37.6554;91.8104;146.406;665.276 3.96047;13.2791;44.1594;95.6156;433.686 29.4997;101.065;186.93;325.091;1425.48 2 3 2 64194;310395 INSIG1_8906;CCRN4L_8232 351.46569999999997 351.46569999999997 443.7947822723697 223.48255 223.48255 297.2725698476147 763.2725 763.2725 936.5028276051813 37.6554;665.276 13.2791;433.686 101.065;1425.48 3 192247;29200;84586 SEZ6_9819;INHBA_33300;FGL2_32918 82.95186666666667 91.8104 68.3155268235072 47.91182333333333 44.1594 45.94264059110702 180.5069 186.93 147.9002918155674 10.6392;91.8104;146.406 3.96047;44.1594;95.6156 29.4997;186.93;325.091 0 Exp 5,1(0.2);Hill,2(0.4);Linear,1(0.2);Poly 2,1(0.2) 2.1803345698643355 11.42362892627716 1.6593536138534546 3.747737169265747 0.8530464384588804 1.9665359258651733 -46.797515937206896 427.51231593720684 -39.62620759425501 275.906435594255 -91.50540946884723 918.7316894688473 DOWN 0.4 0.6 0.0 GO:0071248 6 cellular response to metal ion 94 103 6 6 4 4 3 3 66 100 2378 0.69589 0.53466 0.75695 2.91 24567;300850;24296 mt1;gsta4;cyp1a1 MT1A_9255;GSTA4_8757;CYP1A1_8415 413.6237666666666 339.498 83.0393 373.2097880883664 229.54161795027287 259.92333372737863 287.79970000000003 260.156 63.0271 239.79249817930076 168.4060824742268 175.99704088462076 531.8083333333334 486.944 119.986 435.9891937586679 314.5246431170406 322.49662523924746 818.334;339.498;83.0393 540.216;260.156;63.0271 988.495;486.944;119.986 2 1 2 300850;24296 GSTA4_8757;CYP1A1_8415 211.26864999999998 211.26864999999998 181.34368586428647 161.59155 161.59155 139.3911819578448 303.46500000000003 303.46500000000003 259.47849021065304 339.498;83.0393 260.156;63.0271 486.944;119.986 1 24567 MT1A_9255 818.334 818.334 540.216 540.216 988.495 988.495 818.334 540.216 988.495 0 Linear,1(0.34);Poly 2,2(0.67) 2.954017078614759 10.382403016090393 1.7527846097946167 6.292444229125977 2.4696214895453825 2.3371741771698 -8.70286570269559 835.9503990360288 16.44894378799455 559.1504562120056 38.440115707877 1025.17655095879 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0098869 4 cellular oxidant detoxification 38 46 10 10 7 8 6 6 63 40 2438 0.99982 0.0012645 0.0012645 13.04 94195;287167;360504;24426;116686;24404 s100a9;hba-a1;hba-a2;gstp1;gsr;gpx1 S100A9_9775;LOC287167_9118;HBA2_32600;GSTP1_8762;GSR_8755;GPX1_33050 240.6200366666667 126.78200000000001 8.00432 357.7608114378835 146.77548176226043 235.8098780073847 186.06471833333333 86.72085000000001 2.69961 303.9299412849436 105.65520139057215 198.99094821273064 352.1675666666667 235.368 25.2254 409.3000288491642 251.48118847942501 282.9087454792644 1.5 96.03295 3.5 140.166 963.318;149.282;131.05;122.514;69.5519;8.00432 802.143;97.0024;88.5948;84.8469;41.1016;2.69961 1158.68;334.152;254.163;216.573;124.212;25.2254 3 3 3 94195;24426;116686 S100A9_9775;GSTP1_8762;GSR_8755 385.1279666666667 122.514 501.4269956769413 309.36383333333333 84.8469 427.31942752880235 499.8216666666667 216.573 572.453811352788 963.318;122.514;69.5519 802.143;84.8469;41.1016 1158.68;216.573;124.212 3 287167;360504;24404 LOC287167_9118;HBA2_32600;GPX1_33050 96.11210666666666 131.05 76.84619710482842 62.76560333333333 88.5948 52.18826113964742 204.51346666666666 254.163 160.33626591340257 149.282;131.05;8.00432 97.0024;88.5948;2.69961 334.152;254.163;25.2254 0 Exp 4,1(0.17);Hill,1(0.17);Poly 2,4(0.67) 2.1661237549728245 14.507128477096558 1.7056305408477783 5.5128583908081055 1.518503826598292 1.798611342906952 -45.64823307571493 526.8883064090483 -57.12988440937323 429.25932107603984 24.659334020283723 679.6757993130497 CONFLICT 0.5 0.5 0.0 GO:0044249 4 cellular biosynthetic process 372 415 35 35 31 27 23 23 46 392 2086 0.99989 3.2463E-4 3.8261E-4 5.54 83472;287877;293820;58835;361042;29685;24539;116682;29200;84029;24426;29739;25283;499709;24890;298452;25426;24296;81508;25612;25748;360887;296925 ugdh;pycr1;psat1;phgdh;pck2;mcm6;lpl;kynu;inhba;hao2;gstp1;gclm;gclc;gar1;esr1;dph2;cyp1b1;cyp1a1;bhmt;asns;alas2;coq8a;aass UGDH_10131;PYCR1_9631;PSAT1_9583;PHGDH_9470;PCK2_9440;MCM6_9210;LPL_32544;KYNU_8979;INHBA_33300;HAO2_8778;GSTP1_8762;GCLM_8700;GCLC_8699;GAR1_8683;ESR1_33192;DPH2_8490;CYP1B1_32710;CYP1A1_8415;BHMT_8143;ASNS_8091;ALAS2_8019;ADCK3_7987;AASS_7936 499709(-0.07184) 197.16589478260872 122.514 1.87441 264.564126641087 156.45424222867774 226.79163481284203 125.045079 69.2223 0.496857 171.48292360035651 99.36993145223096 142.79451945529735 468.01619565217396 216.573 9.53 785.9603627538867 362.0155925604661 681.1483549009404 19.5 629.6030000000001 59.3662;132.668;27.1579;122.826;6.67763;1.87441;900.118;100.381;91.8104;140.856;122.514;190.233;145.958;765.364;12.5403;734.134;229.313;83.0393;5.5396;6.05608;125.506;525.072;5.81076 25.4417;90.3184;10.0144;67.6778;1.48195;0.496857;487.466;72.7231;44.1594;93.5219;84.8469;69.2223;96.7058;587.034;3.74981;463.289;185.32;63.0271;1.97501;2.7438;85.7907;336.426;2.60489 135.068;239.858;103.876;246.456;37.9425;9.53;3428.38;161.456;186.93;282.925;216.573;496.452;280.185;1362.21;51.2968;1764.85;299.27;119.986;37.8319;14.3351;236.762;1038.12;14.0792 13 10 13 83472;287877;293820;58835;361042;29685;24426;29739;25283;499709;25426;24296;25612 UGDH_10131;PYCR1_9631;PSAT1_9583;PHGDH_9470;PCK2_9440;MCM6_9210;GSTP1_8762;GCLM_8700;GCLC_8699;GAR1_8683;CYP1B1_32710;CYP1A1_8415;ASNS_8091 145.61904 122.514 199.81949803026203 98.79469284615385 67.6778 155.6913935563889 273.98012307692306 216.573 354.10013879269417 59.3662;132.668;27.1579;122.826;6.67763;1.87441;122.514;190.233;145.958;765.364;229.313;83.0393;6.05608 25.4417;90.3184;10.0144;67.6778;1.48195;0.496857;84.8469;69.2223;96.7058;587.034;185.32;63.0271;2.7438 135.068;239.858;103.876;246.456;37.9425;9.53;216.573;496.452;280.185;1362.21;299.27;119.986;14.3351 10 24539;116682;29200;84029;24890;298452;81508;25748;360887;296925 LPL_32544;KYNU_8979;INHBA_33300;HAO2_8778;ESR1_33192;DPH2_8490;BHMT_8143;ALAS2_8019;ADCK3_7987;AASS_7936 264.176806 112.9435 330.20049052483444 159.170581 79.2569 193.0628431520975 720.26309 211.846 1103.5177789667816 900.118;100.381;91.8104;140.856;12.5403;734.134;5.5396;125.506;525.072;5.81076 487.466;72.7231;44.1594;93.5219;3.74981;463.289;1.97501;85.7907;336.426;2.60489 3428.38;161.456;186.93;282.925;51.2968;1764.85;37.8319;236.762;1038.12;14.0792 0 Exp 2,3(0.14);Exp 4,2(0.09);Hill,9(0.4);Linear,2(0.09);Poly 2,7(0.31) 2.131549427159608 53.52625608444214 1.528982162475586 6.292444229125977 1.238627879931612 1.7978414297103882 89.04164444231624 305.29014512290115 54.962022782768 195.12813521723203 146.80342920921714 789.2289620951307 CONFLICT 0.5652173913043478 0.43478260869565216 0.0 GO:0007154 3 cell communication 162 169 10 10 8 8 6 6 63 163 2315 0.83016 0.30669 0.45854 3.55 94195;59107;24539;170496;24426;25612 s100a9;ltbp1;lpl;lcn2;gstp1;asns S100A9_9775;LTBP1_33264;LPL_32544;LCN2_32481;GSTP1_8762;ASNS_8091 622.3376800000001 834.7560000000001 6.05608 439.859903781709 655.1257302681606 445.6968149492837 394.52628333333337 462.74649999999997 2.7438 300.28405569665813 395.70116077678455 284.9579267526786 1852.2896833333334 1684.94 14.3351 1681.1123237441577 2219.696653518822 1811.295946929448 963.318;769.394;900.118;972.626;122.514;6.05608 802.143;438.027;487.466;551.931;84.8469;2.7438 1158.68;2211.2;3428.38;4084.57;216.573;14.3351 4 2 4 94195;170496;24426;25612 S100A9_9775;LCN2_32481;GSTP1_8762;ASNS_8091 516.12852 542.9159999999999 523.9194164091156 360.416175 318.38895 381.0811240324592 1368.5395250000001 687.6265000000001 1878.0982456350278 963.318;972.626;122.514;6.05608 802.143;551.931;84.8469;2.7438 1158.68;4084.57;216.573;14.3351 2 59107;24539 LTBP1_33264;LPL_32544 834.7560000000001 834.7560000000001 92.43582686382874 462.74649999999997 462.74649999999997 34.958652155082945 2819.79 2819.79 860.6762319246413 769.394;900.118 438.027;487.466 2211.2;3428.38 0 Exp 2,2(0.34);Hill,1(0.17);Linear,1(0.17);Poly 2,2(0.34) 2.3277936490478135 15.825621008872986 1.5140434503555298 5.5128583908081055 1.5925074328301667 1.7813107371330261 270.3764546255353 974.2989053744649 154.24899664556978 634.8035700210969 507.1196681306153 3197.4596985360513 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0043933 5 protein-containing complex subunit organization 226 259 15 15 14 6 5 5 64 254 2224 0.28136 0.84656 0.54518 1.93 83472;29685;312538;24539;24207 ugdh;mcm6;mcm2;lpl;apoc3 UGDH_10131;MCM6_9210;MCM2_9206;LPL_32544;APOC3_32553 193.60035 3.76863 1.87441 395.71367831378177 118.07722004528328 324.28949449767407 103.09962600000001 1.13737 0.496857 215.13087391734547 62.647436939974874 176.0254281779475 720.827622 22.9217 8.23841 1514.4928674694495 439.01480839789787 1237.8553253101857 59.3662;1.87441;3.76863;900.118;2.87451 25.4417;0.496857;0.956203;487.466;1.13737 135.068;9.53;22.9217;3428.38;8.23841 3 2 3 83472;29685;312538 UGDH_10131;MCM6_9210;MCM2_9206 21.66974666666667 3.76863 32.65982184253664 8.964920000000001 0.956203 14.271158294379228 55.8399 22.9217 68.93948998527623 59.3662;1.87441;3.76863 25.4417;0.496857;0.956203 135.068;9.53;22.9217 2 24539;24207 LPL_32544;APOC3_32553 451.496255 451.496255 634.4469561544843 244.301685 244.301685 343.8862721581635 1718.309205 1718.309205 2418.4053109071406 900.118;2.87451 487.466;1.13737 3428.38;8.23841 0 Exp 2,1(0.2);Exp 4,1(0.2);Hill,3(0.6) 1.626044287671922 8.150175094604492 1.5235437154769897 1.8211764097213745 0.1292910836582559 1.5737498998641968 -153.25798225975132 540.4586822597513 -85.4708991901434 291.67015119014343 -606.6839072153057 2048.3391512153057 UP 0.6 0.4 0.0 GO:0006778 5 porphyrin-containing compound metabolic process 14 15 3 3 2 3 2 2 67 13 2465 0.99314 0.060519 0.060519 13.33 24296;25748 cyp1a1;alas2 CYP1A1_8415;ALAS2_8019 104.27265 104.27265 83.0393 30.02849154461478 92.99301491346996 25.44110785862992 74.4089 74.4089 63.0271 16.096295924218058 68.36263077597894 13.637301764693408 178.374 178.374 119.986 82.57310147984029 147.35697567589122 69.95859841474305 0.0 83.0393 0.5 104.27265 83.0393;125.506 63.0271;85.7907 119.986;236.762 1 1 1 24296 CYP1A1_8415 83.0393 83.0393 63.0271 63.0271 119.986 119.986 83.0393 63.0271 119.986 1 25748 ALAS2_8019 125.506 125.506 85.7907 85.7907 236.762 236.762 125.506 85.7907 236.762 0 Poly 2,2(1) 3.326573151247804 8.051075458526611 1.7586312294006348 6.292444229125977 3.205889916737512 4.025537729263306 62.655284 145.890016 52.100572 96.717228 63.93351999999999 292.81448 CONFLICT 0.5 0.5 0.0 GO:0007062 5 sister chromatid cohesion 12 13 2 2 2 1 1 1 68 12 2466 0.95346 0.30085 0.30085 7.69 293502 kif22 KIF22_8963 0.961856 0.961856 0.961856 0.961856 0.281971 0.281971 0.281971 0.281971 4.47267 4.47267 4.47267 4.47267 0.0 0.961856 0.961856 0.281971 4.47267 1 0 1 293502 KIF22_8963 0.961856 0.961856 0.281971 0.281971 4.47267 4.47267 0.961856 0.281971 4.47267 0 0 Exp 4,1(1) 2.092013359069824 2.092013359069824 2.092013359069824 2.092013359069824 0.0 2.092013359069824 0.961856 0.961856 0.281971 0.281971 4.47267 4.47267 UP 1.0 0.0 0.0 GO:0034470 8 ncRNA processing 32 40 2 2 2 2 2 2 67 38 2440 0.9077 0.29553 0.29553 5.0 291317;499709 rpp38;gar1 RPP38_9741;GAR1_8683 499709(-0.07184) 841.163 841.163 765.364 107.19597381431859 882.9145803278689 89.46836246546174 678.473 678.473 587.034 129.31427392983377 728.8394000000001 107.92883277456436 1206.9650000000001 1206.9650000000001 1051.72 219.54958449061098 1121.453 183.2414138834349 1.0 916.962 916.962;765.364 769.912;587.034 1051.72;1362.21 1 1 1 499709 GAR1_8683 765.364 765.364 587.034 587.034 1362.21 1362.21 765.364 587.034 1362.21 1 291317 RPP38_9741 916.962 916.962 769.912 769.912 1051.72 1051.72 916.962 769.912 1051.72 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.6070581604933996 3.2142179012298584 1.5943320989608765 1.619885802268982 0.01806919689359049 1.6071089506149292 692.5969600000001 989.7290399999999 499.2525599999999 857.69344 902.6848000000002 1511.2452 CONFLICT 0.5 0.5 0.0 GO:0006281 6 DNA repair 69 74 5 5 5 4 4 4 65 70 2408 0.95203 0.13847 0.13847 5.41 313108;29685;312538;293502 mms22l;mcm6;mcm2;kif22 MMS22L_33129;MCM6_9210;MCM2_9206;KIF22_8963 2.685014 2.82152 0.961856 1.5169596121356252 2.5958213578512397 1.5290470934487568 0.7455302500000001 0.72653 0.281971 0.43690988923680424 0.7343160925964188 0.4555665444196894 14.4549925 15.212800000000001 4.47267 8.889485820876166 13.596808863292013 8.558965860329597 2.5 3.951895 4.13516;1.87441;3.76863;0.961856 1.24709;0.496857;0.956203;0.281971 20.8956;9.53;22.9217;4.47267 4 0 4 313108;29685;312538;293502 MMS22L_33129;MCM6_9210;MCM2_9206;KIF22_8963 2.685014 2.82152 1.5169596121356252 0.7455302500000001 0.72653 0.43690988923680424 14.4549925 15.212800000000001 8.889485820876166 4.13516;1.87441;3.76863;0.961856 1.24709;0.496857;0.956203;0.281971 20.8956;9.53;22.9217;4.47267 0 0 Exp 4,2(0.5);Hill,2(0.5) 1.7620713681375777 7.097162127494812 1.5280487537384033 2.092013359069824 0.24344186379779859 1.7385500073432922 1.1983935801070873 4.1716344198929125 0.31735855854793177 1.1737019414520684 5.7432963955413605 23.16668860445864 UP 1.0 0.0 0.0 GO:0031400 8 negative regulation of protein modification process 161 172 11 11 9 4 2 2 67 170 2308 0.14334 0.9539 0.32416 1.16 24426;25283 gstp1;gclc GSTP1_8762;GCLC_8699 134.236 134.236 122.514 16.577411378137445 140.95172916666667 13.587072220312082 90.77635000000001 90.77635000000001 84.8469 8.385508607412872 94.17343072916667 6.872877100897864 248.37900000000002 248.37900000000002 216.573 44.980476564838575 266.6011875 36.866611417782224 122.514;145.958 84.8469;96.7058 216.573;280.185 2 0 2 24426;25283 GSTP1_8762;GCLC_8699 134.236 134.236 16.577411378137445 90.77635000000001 90.77635000000001 8.385508607412872 248.37900000000002 248.37900000000002 44.980476564838575 122.514;145.958 84.8469;96.7058 216.573;280.185 0 0 Poly 2,2(1) 3.1152219061433644 7.273216962814331 1.7603585720062256 5.5128583908081055 2.6534180682761 3.6366084814071655 111.26087999999999 157.21112 79.15462800000002 102.398072 186.03924000000004 310.71876000000003 UP 1.0 0.0 0.0 GO:0048584 5 positive regulation of response to stimulus 502 537 20 20 16 13 10 10 59 527 1951 0.10987 0.93997 0.23002 1.86 94195;316351;24539;29200;25663;24404;25317;24890;25426;117517 s100a9;npas2;lpl;inhba;il1r1;gpx1;fgf1;esr1;cyp1b1;c7 S100A9_9775;NPAS2_9350;LPL_32544;INHBA_33300;IL1R1_8893;GPX1_33050;FGF1_8633;ESR1_33192;CYP1B1_32710;C7_8179 311.274722 97.83420000000001 8.00432 380.71136957475034 261.1756961255638 318.3034990207049 203.779522 38.4454 2.69961 278.02060483503004 164.98429329189966 216.89818059301314 730.88562 254.46550000000002 25.2254 1064.3340975452709 617.78303569908 928.4345560267826 963.318;53.0014;900.118;91.8104;76.6218;8.00432;674.162;12.5403;229.313;103.858 802.143;14.3825;487.466;44.1594;27.5215;2.69961;437.622;3.74981;185.32;32.7314 1158.68;215.15;3428.38;186.93;185.143;25.2254;1465.0;51.2968;299.27;293.781 4 6 4 94195;25663;25317;25426 S100A9_9775;IL1R1_8893;FGF1_8633;CYP1B1_32710 485.8537 451.7375 406.9054158554458 363.151625 311.471 337.9008393669596 777.02325 728.975 631.8080619900188 963.318;76.6218;674.162;229.313 802.143;27.5215;437.622;185.32 1158.68;185.143;1465.0;299.27 6 316351;24539;29200;24404;24890;117517 NPAS2_9350;LPL_32544;INHBA_33300;GPX1_33050;ESR1_33192;C7_8179 194.8887366666667 72.4059 347.7265610285462 97.53145333333333 23.55695 191.72813943179293 700.1272 201.04000000000002 1340.412485257979 53.0014;900.118;91.8104;8.00432;12.5403;103.858 14.3825;487.466;44.1594;2.69961;3.74981;32.7314 215.15;3428.38;186.93;25.2254;51.2968;293.781 0 Exp 2,1(0.1);Hill,6(0.6);Linear,2(0.2);Poly 2,1(0.1) 1.971939764470515 20.238367080688477 1.5704141855239868 3.1843981742858887 0.5238921776158114 1.7582497000694275 75.30737044024522 547.2420735597548 31.46056584368199 376.09847815631804 71.20451183391503 1390.5667281660849 DOWN 0.4 0.6 0.0 GO:2000026 5 regulation of multicellular organismal development 487 514 27 27 22 16 12 12 57 502 1976 0.34126 0.76538 0.64953 2.33 192247;94195;338475;259241;29200;25663;24404;84586;25317;24890;25426;310395 sez6;s100a9;nrep;nr1d2;inhba;il1r1;gpx1;fgl2;fgf1;esr1;cyp1b1;noct SEZ6_9819;S100A9_9775;NREP_9364;NR1D2_9358;INHBA_33300;IL1R1_8893;GPX1_33050;FGL2_32918;FGF1_8633;ESR1_33192;CYP1B1_32710;CCRN4L_8232 256.5592025 119.10820000000001 8.00432 324.80506558982677 232.73673620342032 291.00734525454345 179.5480575 69.8875 2.2133 251.51264624330148 156.8509262745274 206.61412826560684 470.75879166666664 243.1 25.2254 550.4712264066892 460.09322385988594 576.5095619974061 10.6392;963.318;191.159;9.46041;91.8104;76.6218;8.00432;146.406;674.162;12.5403;229.313;665.276 3.96047;802.143;115.886;2.2133;44.1594;27.5215;2.69961;95.6156;437.622;3.74981;185.32;433.686 29.4997;1158.68;448.068;49.4216;186.93;185.143;25.2254;325.091;1465.0;51.2968;299.27;1425.48 6 6 6 94195;259241;25663;25317;25426;310395 S100A9_9775;NR1D2_9358;IL1R1_8893;FGF1_8633;CYP1B1_32710;CCRN4L_8232 436.358535 447.29449999999997 385.00918241037596 314.75096666666667 309.503 304.5412162195893 763.8324333333334 728.975 655.1947211972993 963.318;9.46041;76.6218;674.162;229.313;665.276 802.143;2.2133;27.5215;437.622;185.32;433.686 1158.68;49.4216;185.143;1465.0;299.27;1425.48 6 192247;338475;29200;24404;84586;24890 SEZ6_9819;NREP_9364;INHBA_33300;GPX1_33050;FGL2_32918;ESR1_33192 76.75986999999999 52.17535 79.23090893085983 44.34514833333333 24.059935 50.51740645618515 177.68515000000002 119.1134 176.6905517662758 10.6392;191.159;91.8104;8.00432;146.406;12.5403 3.96047;115.886;44.1594;2.69961;95.6156;3.74981 29.4997;448.068;186.93;25.2254;325.091;51.2968 0 Hill,6(0.5);Linear,3(0.25);Poly 2,3(0.25) 2.052143211381939 25.595228910446167 1.5704141855239868 3.747737169265747 0.6812662860353556 1.7710742950439453 72.7834362886083 440.33496871139175 37.241381367098 321.8547336329019 159.3003751345621 782.2172081987712 CONFLICT 0.5 0.5 0.0 GO:0048585 5 negative regulation of response to stimulus 377 396 28 28 24 17 13 13 56 383 2095 0.82634 0.26755 0.40386 3.28 308843;287877;259241;59107;24539;288001;64194;24426;24404;29739;25283;84586;24890 tsku;pycr1;nr1d2;ltbp1;lpl;kng1;insig1;gstp1;gpx1;gclm;gclc;fgl2;esr1 TSKU_10094;PYCR1_9631;NR1D2_9358;LTBP1_33264;LPL_32544;KNG1L1_32433;INSIG1_8906;GSTP1_8762;GPX1_33050;GCLM_8700;GCLC_8699;FGL2_32918;ESR1_33192 288001(0.1788) 197.77897615384614 122.514 3.87556 290.8987904629456 136.49804648290234 237.63752221583178 110.34502538461538 69.2223 1.25511 161.36360525577837 74.80875066654038 131.2987546550805 586.4987846153846 216.573 13.8374 1031.0676697882361 400.13084376243256 862.0886797271812 92.2997;132.668;9.46041;769.394;900.118;3.87556;37.6554;122.514;8.00432;190.233;145.958;146.406;12.5403 49.0864;90.3184;2.2133;438.027;487.466;1.25511;13.2791;84.8469;2.69961;69.2223;96.7058;95.6156;3.74981 185.899;239.858;49.4216;2211.2;3428.38;13.8374;101.065;216.573;25.2254;496.452;280.185;325.091;51.2968 8 5 8 308843;287877;259241;288001;64194;24426;29739;25283 TSKU_10094;PYCR1_9631;NR1D2_9358;KNG1L1_32433;INSIG1_8906;GSTP1_8762;GCLM_8700;GCLC_8699 91.83300875 107.40684999999999 68.32493959676498 50.865913750000004 59.15435 40.34441383865497 197.911375 201.236 152.8113630770187 92.2997;132.668;9.46041;3.87556;37.6554;122.514;190.233;145.958 49.0864;90.3184;2.2133;1.25511;13.2791;84.8469;69.2223;96.7058 185.899;239.858;49.4216;13.8374;101.065;216.573;496.452;280.185 5 59107;24539;24404;84586;24890 LTBP1_33264;LPL_32544;GPX1_33050;FGL2_32918;ESR1_33192 367.29252400000007 146.406 432.8153749947255 205.51160399999998 95.6156 238.4739760038211 1208.23864 325.091 1537.2819885459492 769.394;900.118;8.00432;146.406;12.5403 438.027;487.466;2.69961;95.6156;3.74981 2211.2;3428.38;25.2254;325.091;51.2968 0 Exp 2,2(0.16);Exp 4,2(0.16);Exp 5,1(0.08);Hill,4(0.31);Poly 2,4(0.31) 2.026565284664365 28.393364787101746 1.5140434503555298 5.5128583908081055 1.1019389724995214 1.7646474838256836 39.64459232539801 355.9133599822943 22.62677035560452 198.06328041362622 26.004014637420823 1146.9935545933486 UP 0.6153846153846154 0.38461538461538464 0.0 GO:0048513 4 animal organ development 418 452 31 31 27 18 14 14 55 438 2040 0.76915 0.33438 0.52663 3.1 308843;360243;58835;24614;29200;24426;25317;24890;25315;24309;25426;24296;25612;25748 tsku;top2a;phgdh;orm1;inhba;gstp1;fgf1;esr1;ephx1;dbp;cyp1b1;cyp1a1;asns;alas2 TSKU_10094;TOP2A_10059;PHGDH_9470;ORM1_9400;INHBA_33300;GSTP1_8762;FGF1_8633;ESR1_33192;EPHX1_8567;DBP_8439;CYP1B1_32710;CYP1A1_8415;ASNS_8091;ALAS2_8019 165.44037714285747 92.05505 4.48597E-12 221.4968711271168 157.03670599247664 211.96889504209955 106.36350785714318 56.056749999999994 4.48597E-12 147.4220607689611 102.06114208114332 142.36594305181873 341.30297857142887 201.75150000000002 4.48599E-12 475.1801571169273 321.5823279491237 453.2720971642009 92.2997;4.48597E-12;122.826;662.49;91.8104;122.514;674.162;12.5403;27.5708;66.0377;229.313;83.0393;6.05608;125.506 49.0864;4.48597E-12;67.6778;432.445;44.1594;84.8469;437.622;3.74981;12.6303;19.9899;185.32;63.0271;2.7438;85.7907 185.899;4.48599E-12;246.456;1413.32;186.93;216.573;1465.0;51.2968;61.9858;280.428;299.27;119.986;14.3351;236.762 11 3 11 308843;360243;58835;24614;24426;25317;25315;24309;25426;24296;25612 TSKU_10094;TOP2A_10059;PHGDH_9470;ORM1_9400;GSTP1_8762;FGF1_8633;EPHX1_8567;DBP_8439;CYP1B1_32710;CYP1A1_8415;ASNS_8091 189.66441636363678 92.2997 245.14114801646986 123.21720000000042 63.0271 162.6609213195102 391.20480909090946 216.573 528.1188148916157 92.2997;4.48597E-12;122.826;662.49;122.514;674.162;27.5708;66.0377;229.313;83.0393;6.05608 49.0864;4.48597E-12;67.6778;432.445;84.8469;437.622;12.6303;19.9899;185.32;63.0271;2.7438 185.899;4.48599E-12;246.456;1413.32;216.573;1465.0;61.9858;280.428;299.27;119.986;14.3351 3 29200;24890;25748 INHBA_33300;ESR1_33192;ALAS2_8019 76.6189 91.8104 57.99481527093608 44.56663666666666 44.1594 41.02196106081513 158.3296 186.93 95.98344785888871 91.8104;12.5403;125.506 44.1594;3.74981;85.7907 186.93;51.2968;236.762 0 Exp 4,3(0.22);Hill,5(0.36);Linear,3(0.22);Poly 2,3(0.22) 2.516942510783174 39.30266451835632 1.5487829446792603 6.292444229125977 1.4955408948410525 2.0975494384765625 49.413220582844545 281.4675337028704 29.13910988619638 183.58790582809002 92.38839028193547 590.2175668609223 UP 0.7857142857142857 0.21428571428571427 0.0 GO:0008631 7 intrinsic apoptotic signaling pathway in response to oxidative stress 9 9 2 2 2 2 2 2 67 7 2471 0.99858 0.023028 0.023028 22.22 24404;25426 gpx1;cyp1b1 GPX1_33050;CYP1B1_32710 118.65866 118.65866 8.00432 156.48886836344366 146.33439261275953 151.51525853974337 94.009805 94.009805 2.69961 129.13211615193197 116.84737776613761 125.02797271882315 162.24769999999998 162.24769999999998 25.2254 193.77879500755492 196.5183172824791 187.6200175267439 0.0 8.00432 0.0 8.00432 8.00432;229.313 2.69961;185.32 25.2254;299.27 1 1 1 25426 CYP1B1_32710 229.313 229.313 185.32 185.32 299.27 299.27 229.313 185.32 299.27 1 24404 GPX1_33050 8.00432 8.00432 2.69961 2.69961 25.2254 25.2254 8.00432 2.69961 25.2254 0 Hill,1(0.5);Linear,1(0.5) 2.383903492523155 4.969035506248474 1.7846373319625854 3.1843981742858887 0.9897803836462015 2.484517753124237 -98.22384639999999 335.54116639999995 -84.95817719999997 272.97778719999997 -106.31600800000001 430.81140800000003 CONFLICT 0.5 0.5 0.0 GO:0009968 6 negative regulation of signal transduction 284 297 21 21 17 12 8 8 61 289 2189 0.58606 0.5644 1.0 2.69 308843;59107;64194;24426;24404;29739;25283;24890 tsku;ltbp1;insig1;gstp1;gpx1;gclm;gclc;esr1 TSKU_10094;LTBP1_33264;INSIG1_8906;GSTP1_8762;GPX1_33050;GCLM_8700;GCLC_8699;ESR1_33192 172.32484 107.40684999999999 8.00432 249.8744906859092 109.68551986789365 172.05609569174425 94.70211499999999 59.15435 2.69961 143.46210111121553 56.62789281234122 98.08856172499074 445.987025 201.236 25.2254 728.8035567218169 275.6166096313442 488.4969201740457 92.2997;769.394;37.6554;122.514;8.00432;190.233;145.958;12.5403 49.0864;438.027;13.2791;84.8469;2.69961;69.2223;96.7058;3.74981 185.899;2211.2;101.065;216.573;25.2254;496.452;280.185;51.2968 5 3 5 308843;64194;24426;29739;25283 TSKU_10094;INSIG1_8906;GSTP1_8762;GCLM_8700;GCLC_8699 117.73202 122.514 57.304086572966135 62.6281 69.2223 32.85250988988511 256.0348 216.573 149.06002585267458 92.2997;37.6554;122.514;190.233;145.958 49.0864;13.2791;84.8469;69.2223;96.7058 185.899;101.065;216.573;496.452;280.185 3 59107;24404;24890 LTBP1_33264;GPX1_33050;ESR1_33192 263.31287333333336 12.5403 438.28498018388916 148.15880666666666 3.74981 251.03376836544928 762.5740666666666 51.2968 1254.6145824590487 769.394;8.00432;12.5403 438.027;2.69961;3.74981 2211.2;25.2254;51.2968 0 Exp 2,1(0.13);Exp 4,1(0.13);Exp 5,1(0.13);Hill,3(0.38);Poly 2,2(0.25) 2.2096649012015335 19.513131022453308 1.5140434503555298 5.5128583908081055 1.362685540677489 1.8467147946357727 -0.829347873350315 345.47902787335033 -4.712049048230426 194.11627904823044 -59.048073368654 951.0221233686539 UP 0.625 0.375 0.0 GO:0009635 4 response to herbicide 15 16 4 4 4 3 3 3 66 13 2465 0.9993 0.0082757 0.0082757 18.75 170496;300850;24296 lcn2;gsta4;cyp1a1 LCN2_32481;GSTA4_8757;CYP1A1_8415 465.0544333333333 339.498 83.0393 457.89129459705106 346.29236505460216 420.97869114575275 291.7047 260.156 63.0271 245.97407630189414 223.87837051482057 233.06349497460178 1563.8333333333333 486.944 119.986 2190.7189574314034 1069.8603634945398 1930.132120624498 0.0 83.0393 0.5 211.26864999999998 972.626;339.498;83.0393 551.931;260.156;63.0271 4084.57;486.944;119.986 3 0 3 170496;300850;24296 LCN2_32481;GSTA4_8757;CYP1A1_8415 465.0544333333333 339.498 457.89129459705106 291.7047 260.156 245.97407630189414 1563.8333333333333 486.944 2190.7189574314034 972.626;339.498;83.0393 551.931;260.156;63.0271 4084.57;486.944;119.986 0 0 Linear,2(0.67);Poly 2,1(0.34) 2.7360198037137136 9.902219772338867 1.7527846097946167 6.292444229125977 2.5914157763558268 1.856990933418274 -53.09834456924625 983.207211235913 13.358829633526568 570.0505703664735 -915.1985390586669 4042.865205725334 UP 1.0 0.0 0.0 GO:0043434 5 response to peptide hormone 194 204 15 15 12 10 7 7 62 197 2281 0.81676 0.3136 0.49683 3.43 361042;24614;64194;24426;25283;25426;24207 pck2;orm1;insig1;gstp1;gclc;cyp1b1;apoc3 PCK2_9440;ORM1_9400;INSIG1_8906;GSTP1_8762;GCLC_8699;CYP1B1_32710;APOC3_32553 172.49750571428572 122.514 2.87451 231.29127609458408 113.26698900000001 169.5571466170128 116.45944571428572 84.8469 1.13737 154.45786665453937 80.08213032102985 119.59882164078671 336.6562728571429 216.573 8.23841 488.3309960819158 202.03719773684213 330.6898111412687 6.67763;662.49;37.6554;122.514;145.958;229.313;2.87451 1.48195;432.445;13.2791;84.8469;96.7058;185.32;1.13737 37.9425;1413.32;101.065;216.573;280.185;299.27;8.23841 6 1 6 361042;24614;64194;24426;25283;25426 PCK2_9440;ORM1_9400;INSIG1_8906;GSTP1_8762;GCLC_8699;CYP1B1_32710 200.768005 134.236 239.75263874689549 135.67979166666666 90.77635000000001 159.76713309726887 391.3925833333333 248.37900000000002 510.8753851293305 6.67763;662.49;37.6554;122.514;145.958;229.313 1.48195;432.445;13.2791;84.8469;96.7058;185.32 37.9425;1413.32;101.065;216.573;280.185;299.27 1 24207 APOC3_32553 2.87451 2.87451 1.13737 1.13737 8.23841 8.23841 2.87451 1.13737 8.23841 0 Exp 4,1(0.15);Exp 5,1(0.15);Hill,1(0.15);Linear,2(0.29);Poly 2,2(0.29) 2.1598428871145408 17.02545988559723 1.5235437154769897 5.5128583908081055 1.4802227617889505 1.7603585720062256 1.1545305640722745 343.84048086449917 2.0354568167492744 230.88343461182214 -25.104391615674785 698.4169373299605 UP 0.8571428571428571 0.14285714285714285 0.0 GO:0001505 4 regulation of neurotransmitter levels 102 115 4 4 3 4 3 3 66 112 2366 0.62062 0.61096 1.0 2.61 58835;24890;25426 phgdh;esr1;cyp1b1 PHGDH_9470;ESR1_33192;CYP1B1_32710 121.55976666666668 122.826 12.5403 108.3918971900729 138.91503698792977 112.80060536323376 85.58253666666667 67.6778 3.74981 92.09977291223922 102.47708242044622 97.17452962674894 199.0076 246.456 51.2968 130.61849017838176 213.14240453547913 130.52514572190864 122.826;12.5403;229.313 67.6778;3.74981;185.32 246.456;51.2968;299.27 2 1 2 58835;25426 PHGDH_9470;CYP1B1_32710 176.0695 176.0695 75.29767980821177 126.49889999999999 126.49889999999999 83.18559737370407 272.863 272.863 37.345137541586105 122.826;229.313 67.6778;185.32 246.456;299.27 1 24890 ESR1_33192 12.5403 12.5403 3.74981 3.74981 51.2968 51.2968 12.5403 3.74981 51.2968 0 Exp 4,1(0.34);Hill,1(0.34);Linear,1(0.34) 2.1483119796884864 6.714101672172546 1.7318620681762695 3.1843981742858887 0.8202391949535569 1.7978414297103882 -1.0972117338324665 244.2167450671658 -18.63816755237538 189.8032408857087 51.198863887362904 346.8163361126371 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0006690 6 icosanoid metabolic process 39 48 5 5 4 5 4 4 65 44 2434 0.99125 0.039219 0.039219 8.33 24426;24404;25315;25426 gstp1;gpx1;ephx1;cyp1b1 GSTP1_8762;GPX1_33050;EPHX1_8567;CYP1B1_32710 96.85052999999999 75.0424 8.00432 101.48604119315918 103.04843970281873 115.37898867649746 71.3742025 48.738600000000005 2.69961 84.32517236232621 78.30263513048347 97.06528512139491 150.76355 139.2794 25.2254 129.13347797452317 149.86107868583161 140.15028337690978 1.5 75.0424 122.514;8.00432;27.5708;229.313 84.8469;2.69961;12.6303;185.32 216.573;25.2254;61.9858;299.27 3 1 3 24426;25315;25426 GSTP1_8762;EPHX1_8567;CYP1B1_32710 126.46593333333333 122.514 100.92914419538755 94.26573333333333 84.8469 86.7292853512776 192.6096 216.573 120.44347760289885 122.514;27.5708;229.313 84.8469;12.6303;185.32 216.573;61.9858;299.27 1 24404 GPX1_33050 8.00432 8.00432 2.69961 2.69961 25.2254 25.2254 8.00432 2.69961 25.2254 0 Hill,2(0.5);Linear,1(0.25);Poly 2,1(0.25) 3.1369631764864963 13.572783589363098 1.7846373319625854 5.5128583908081055 1.550850871319655 3.1376439332962036 -2.6057903692959883 196.30685036929597 -11.264466415079696 154.0128714150797 24.212741584967276 277.31435841503276 UP 0.75 0.25 0.0 GO:0032870 5 cellular response to hormone stimulus 198 212 22 22 18 16 12 12 57 200 2278 0.99631 0.01006 0.012344 5.66 361042;24614;59107;64194;29200;24426;29739;25283;24890;25315;25426;25612 pck2;orm1;ltbp1;insig1;inhba;gstp1;gclm;gclc;esr1;ephx1;cyp1b1;asns PCK2_9440;ORM1_9400;LTBP1_33264;INSIG1_8906;INHBA_33300;GSTP1_8762;GCLM_8700;GCLC_8699;ESR1_33192;EPHX1_8567;CYP1B1_32710;ASNS_8091 191.8510508333333 107.1622 6.05608 256.74721150387705 123.61857563732502 178.46272282644736 115.38428 56.69085 1.48195 158.7192720679725 76.62056582737168 116.20789188120668 447.54626666666667 201.75150000000002 14.3351 674.0661716293739 260.78260360186624 434.7437602185544 9.5 445.9015 6.67763;662.49;769.394;37.6554;91.8104;122.514;190.233;145.958;12.5403;27.5708;229.313;6.05608 1.48195;432.445;438.027;13.2791;44.1594;84.8469;69.2223;96.7058;3.74981;12.6303;185.32;2.7438 37.9425;1413.32;2211.2;101.065;186.93;216.573;496.452;280.185;51.2968;61.9858;299.27;14.3351 9 3 9 361042;24614;64194;24426;29739;25283;25315;25426;25612 PCK2_9440;ORM1_9400;INSIG1_8906;GSTP1_8762;GCLM_8700;GCLC_8699;EPHX1_8567;CYP1B1_32710;ASNS_8091 158.71865666666665 122.514 206.0079796878456 99.85279444444444 69.2223 138.43106316837012 324.5698222222222 216.573 436.820818343548 6.67763;662.49;37.6554;122.514;190.233;145.958;27.5708;229.313;6.05608 1.48195;432.445;13.2791;84.8469;69.2223;96.7058;12.6303;185.32;2.7438 37.9425;1413.32;101.065;216.573;496.452;280.185;61.9858;299.27;14.3351 3 59107;29200;24890 LTBP1_33264;INHBA_33300;ESR1_33192 291.2482333333333 91.8104 415.9789271398773 161.97873666666666 44.1594 239.91710340866496 816.4755999999999 186.93 1209.7690710222676 769.394;91.8104;12.5403 438.027;44.1594;3.74981 2211.2;186.93;51.2968 0 Exp 2,1(0.09);Exp 5,1(0.09);Hill,6(0.5);Linear,2(0.17);Poly 2,2(0.17) 2.2628966389242287 29.572435975074768 1.5140434503555298 5.5128583908081055 1.1900971620306364 1.9376640915870667 46.58264059139313 337.11946107527353 25.58039783505511 205.18816216494486 66.15742673766385 828.9351065956695 UP 0.75 0.25 0.0 GO:0046685 4 response to arsenic-containing substance 19 20 4 4 4 3 3 3 66 17 2461 0.99828 0.015593 0.015593 15.0 25283;25426;24296 gclc;cyp1b1;cyp1a1 GCLC_8699;CYP1B1_32710;CYP1A1_8415 152.77009999999999 145.958 83.0393 73.37439851698954 155.18640672994664 80.15650239019571 115.01763333333334 96.7058 63.0271 63.16946079889654 119.5043647451827 68.31460235633402 233.14700000000002 280.185 119.986 98.46379155303735 225.28022711532975 103.70667249688306 0.0 83.0393 1.0 145.958 145.958;229.313;83.0393 96.7058;185.32;63.0271 280.185;299.27;119.986 3 0 3 25283;25426;24296 GCLC_8699;CYP1B1_32710;CYP1A1_8415 152.77009999999999 145.958 73.37439851698954 115.01763333333334 96.7058 63.16946079889654 233.14700000000002 280.185 98.46379155303735 145.958;229.313;83.0393 96.7058;185.32;63.0271 280.185;299.27;119.986 0 0 Linear,1(0.34);Poly 2,2(0.67) 3.2795628652911826 11.23720097541809 1.7603585720062256 6.292444229125977 2.3176007519033712 3.1843981742858887 69.73915167859482 235.80104832140515 43.53465914759266 186.500607519074 121.7247307451884 344.5692692548115 UP 1.0 0.0 0.0 GO:0043065 8 positive regulation of apoptotic process 196 210 10 10 8 5 4 4 65 206 2272 0.3147 0.83441 0.6554 1.9 360243;94195;29200;25426 top2a;s100a9;inhba;cyp1b1 TOP2A_10059;S100A9_9775;INHBA_33300;CYP1B1_32710 321.1103500000011 160.5617 4.48597E-12 438.3863376568918 204.54755412861422 284.0176919804614 257.90560000000113 114.7397 4.48597E-12 371.33352187843104 161.3281193296311 239.92322686722304 411.22000000000116 243.1 4.48599E-12 513.3670378329058 272.0916457960655 336.31000832931926 4.48597E-12;963.318;91.8104;229.313 4.48597E-12;802.143;44.1594;185.32 4.48599E-12;1158.68;186.93;299.27 3 1 3 360243;94195;25426 TOP2A_10059;S100A9_9775;CYP1B1_32710 397.5436666666681 229.313 503.2112480721506 329.1543333333348 185.32 419.9697425962159 485.9833333333349 299.27 601.4825327749188 4.48597E-12;963.318;229.313 4.48597E-12;802.143;185.32 4.48599E-12;1158.68;299.27 1 29200 INHBA_33300 91.8104 91.8104 44.1594 44.1594 186.93 186.93 91.8104 44.1594 186.93 0 Hill,2(0.5);Linear,1(0.25);Poly 2,1(0.25) 2.1614635863395533 8.935478568077087 1.7056305408477783 3.1843981742858887 0.687326376927184 2.02272492647171 -108.5082609037529 750.7289609037551 -106.00125144086132 621.8124514408636 -91.8796970762466 914.3196970762488 UP 0.75 0.25 0.0 GO:0009308 5 amine metabolic process 16 18 3 3 3 2 2 2 67 16 2462 0.9884 0.083748 0.083748 11.11 116682;24296 kynu;cyp1a1 KYNU_8979;CYP1A1_8415 91.71015 91.71015 83.0393 12.262433667302728 88.62723552668737 11.461176036754592 67.8751 67.8751 63.0271 6.85610735038455 66.15139709121718 6.408112402611669 140.721 140.721 119.986 29.32371821580595 133.34868568201074 27.40763421372838 0.0 83.0393 0.5 91.71015 100.381;83.0393 72.7231;63.0271 161.456;119.986 1 1 1 24296 CYP1A1_8415 83.0393 83.0393 63.0271 63.0271 119.986 119.986 83.0393 63.0271 119.986 1 116682 KYNU_8979 100.381 100.381 72.7231 72.7231 161.456 161.456 100.381 72.7231 161.456 0 Poly 2,2(1) 3.509607590684281 8.249926090240479 1.957481861114502 6.292444229125977 3.0652812866094075 4.124963045120239 74.715284 108.705016 58.37302 77.37718000000001 100.08040000000003 181.36159999999998 CONFLICT 0.5 0.5 0.0 GO:0051172 6 negative regulation of nitrogen compound metabolic process 471 499 23 23 17 13 8 8 61 491 1987 0.055328 0.97415 0.092609 1.6 299270;259241;288001;24426;24404;25283;24890;310395 serpina6;nr1d2;kng1;gstp1;gpx1;gclc;esr1;noct SERPINA6_32325;NR1D2_9358;KNG1L1_32433;GSTP1_8762;GPX1_33050;GCLC_8699;ESR1_33192;CCRN4L_8232 288001(0.1788) 124.17538624999999 19.1574 3.87556 225.6861076074437 122.73095161700049 240.4886645746712 79.16628125 5.961765 1.25511 148.60820336876515 77.26469764711108 158.3789677377695 270.66165 77.2854 13.8374 476.28113973410706 275.6273426211307 506.50898378587266 25.7745;9.46041;3.87556;122.514;8.00432;145.958;12.5403;665.276 8.17372;2.2133;1.25511;84.8469;2.69961;96.7058;3.74981;433.686 103.274;49.4216;13.8374;216.573;25.2254;280.185;51.2968;1425.48 5 3 5 259241;288001;24426;25283;310395 NR1D2_9358;KNG1L1_32433;GSTP1_8762;GCLC_8699;CCRN4L_8232 189.41679399999998 122.514 273.68617256471396 123.74142200000001 84.8469 178.94226107486574 397.0994 216.573 585.5755779012475 9.46041;3.87556;122.514;145.958;665.276 2.2133;1.25511;84.8469;96.7058;433.686 49.4216;13.8374;216.573;280.185;1425.48 3 299270;24404;24890 SERPINA6_32325;GPX1_33050;ESR1_33192 15.439706666666666 12.5403 9.23307876995173 4.8743799999999995 3.74981 2.9051614992457826 59.932066666666664 51.2968 39.73439144234292 25.7745;8.00432;12.5403 8.17372;2.69961;3.74981 103.274;25.2254;51.2968 0 Exp 4,1(0.13);Hill,4(0.5);Linear,1(0.13);Poly 2,2(0.25) 2.09081642737573 18.319519996643066 1.5755720138549805 5.5128583908081055 1.3155128631992783 1.7724979519844055 -32.217107316643876 280.5678798166439 -23.813949725163297 182.1465122251633 -59.38434118409981 600.7076411840999 UP 0.625 0.375 0.0 GO:0055086 5 nucleobase-containing small molecule metabolic process 108 122 6 6 6 3 3 3 66 119 2359 0.57679 0.65155 1.0 2.46 83472;116682;296925 ugdh;kynu;aass UGDH_10131;KYNU_8979;AASS_7936 55.18598666666666 59.3662 5.81076 47.42349851127113 43.45261853538027 49.60282863719181 33.58989666666667 25.4417 2.60489 35.76221015387658 26.653751910475854 35.93444583272038 103.5344 135.068 14.0792 78.58597992822891 81.32666469031234 83.58812967759802 59.3662;100.381;5.81076 25.4417;72.7231;2.60489 135.068;161.456;14.0792 1 2 1 83472 UGDH_10131 59.3662 59.3662 25.4417 25.4417 135.068 135.068 59.3662 25.4417 135.068 2 116682;296925 KYNU_8979;AASS_7936 53.09588 53.09588 66.87125800243928 37.663995 37.663995 49.58106177566239 87.76759999999999 87.76759999999999 104.21113466957358 100.381;5.81076 72.7231;2.60489 161.456;14.0792 0 Hill,2(0.67);Poly 2,1(0.34) 1.9331422157477 5.876313328742981 1.5737498998641968 2.3450815677642822 0.3856674501401281 1.957481861114502 1.5212461891301245 108.8507271442032 -6.878853785280299 74.05864711861364 14.605992134456756 192.46280786554325 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0046483 4 heterocycle metabolic process 413 462 32 32 30 22 20 20 49 442 2036 0.99177 0.017181 0.025349 4.33 83472;360243;266730;291317;287877;680308;313108;29685;312538;116682;293502;499709;24890;25315;25426;24296;310395;25748;26760;296925 ugdh;top2a;slc17a3;rpp38;pycr1;mthfd2;mms22l;mcm6;mcm2;kynu;kif22;gar1;esr1;ephx1;cyp1b1;cyp1a1;noct;alas2;akr7a3;aass UGDH_10131;TOP2A_10059;SLC17A3_9840;RPP38_9741;PYCR1_9631;MTHFD2_9261;MMS22L_33129;MCM6_9210;MCM2_9206;KYNU_8979;KIF22_8963;GAR1_8683;ESR1_33192;EPHX1_8567;CYP1B1_32710;CYP1A1_8415;CCRN4L_8232;ALAS2_8019;AKR7A3_8015;AASS_7936 499709(-0.07184) 195.38090080000023 71.20275 4.48597E-12 291.34248727781596 154.18661647734254 257.0236244733841 142.5738960500002 48.04685 4.48597E-12 224.34976316530512 113.422479000687 199.88011570824722 335.6824385000003 127.52700000000002 4.48599E-12 492.2593427257291 254.9081116745352 417.38123627314167 59.3662;4.48597E-12;93.3839;916.962;132.668;622.58;4.13516;1.87441;3.76863;100.381;0.961856;765.364;12.5403;27.5708;229.313;83.0393;665.276;125.506;57.1167;5.81076 25.4417;4.48597E-12;68.9252;769.912;90.3184;414.266;1.24709;0.496857;0.956203;72.7231;0.281971;587.034;3.74981;12.6303;185.32;63.0271;433.686;85.7907;33.0666;2.60489 135.068;4.48599E-12;143.418;1051.72;239.858;1250.29;20.8956;9.53;22.9217;161.456;4.47267;1362.21;51.2968;61.9858;299.27;119.986;1425.48;236.762;102.949;14.0792 15 5 15 83472;360243;266730;287877;680308;313108;29685;312538;293502;499709;25315;25426;24296;310395;26760 UGDH_10131;TOP2A_10059;SLC17A3_9840;PYCR1_9631;MTHFD2_9261;MMS22L_33129;MCM6_9210;MCM2_9206;KIF22_8963;GAR1_8683;EPHX1_8567;CYP1B1_32710;CYP1A1_8415;CCRN4L_8232;AKR7A3_8015 183.09453040000028 59.3662 268.1297447514697 127.77982806666697 33.0666 191.33376418662343 346.5556513333337 119.986 525.4344338090796 59.3662;4.48597E-12;93.3839;132.668;622.58;4.13516;1.87441;3.76863;0.961856;765.364;27.5708;229.313;83.0393;665.276;57.1167 25.4417;4.48597E-12;68.9252;90.3184;414.266;1.24709;0.496857;0.956203;0.281971;587.034;12.6303;185.32;63.0271;433.686;33.0666 135.068;4.48599E-12;143.418;239.858;1250.29;20.8956;9.53;22.9217;4.47267;1362.21;61.9858;299.27;119.986;1425.48;102.949 5 291317;116682;24890;25748;296925 RPP38_9741;KYNU_8979;ESR1_33192;ALAS2_8019;AASS_7936 232.24001200000004 100.381 386.38106799766564 186.95610000000002 72.7231 328.12768517567906 303.06280000000004 161.456 427.7363454348017 916.962;100.381;12.5403;125.506;5.81076 769.912;72.7231;3.74981;85.7907;2.60489 1051.72;161.456;51.2968;236.762;14.0792 0 Exp 2,1(0.05);Exp 4,2(0.1);Hill,8(0.4);Linear,3(0.15);Poly 2,6(0.3) 2.0757989027634474 45.757816553115845 1.504341721534729 6.292444229125977 1.2854850742220927 1.75807124376297 67.6944259677357 323.0673756322648 44.248277099974544 240.89951500002599 119.94026933275728 551.4246076672432 UP 0.75 0.25 0.0 GO:0007167 6 enzyme linked receptor protein signaling pathway 141 148 9 9 9 2 2 2 67 146 2332 0.22405 0.91838 0.43332 1.35 29200;25317 inhba;fgf1 INHBA_33300;FGF1_8633 382.9862 382.9862 91.8104 411.7847653948359 471.9371066013453 392.0996881417751 240.8907 240.8907 44.1594 278.2200726032901 300.9898823216807 264.91996030482625 825.965 825.965 186.93 903.7319638310906 1021.1829494312049 860.5297013408376 91.8104;674.162 44.1594;437.622 186.93;1465.0 1 1 1 25317 FGF1_8633 674.162 674.162 437.622 437.622 1465.0 1465.0 674.162 437.622 1465.0 1 29200 INHBA_33300 91.8104 91.8104 44.1594 44.1594 186.93 186.93 91.8104 44.1594 186.93 0 Hill,1(0.5);Linear,1(0.5) 1.897408844309023 3.8629051446914673 1.5704141855239868 2.2924909591674805 0.5105853831806181 1.9314525723457336 -187.71836799999994 953.690768 -144.70264799999998 626.484048 -426.54359999999997 2078.4736 CONFLICT 0.5 0.5 0.0 GO:0006629 4 lipid metabolic process 289 320 32 31 26 19 14 14 55 306 2172 0.97878 0.043936 0.063094 4.38 299270;361042;24539;64194;84029;24426;24404;24890;25315;171142;25426;24296;290277;24207 serpina6;pck2;lpl;insig1;hao2;gstp1;gpx1;esr1;ephx1;ehhadh;cyp1b1;cyp1a1;cryl1;apoc3 SERPINA6_32325;PCK2_9440;LPL_32544;INSIG1_8906;HAO2_8778;GSTP1_8762;GPX1_33050;ESR1_33192;EPHX1_8567;EHHADH_8534;CYP1B1_32710;CYP1A1_8415;CRYL1_8388;APOC3_32553 128.3312757142857 35.22825 2.87451 233.04430559053577 100.31877177569798 183.04336008544664 77.00285428571429 14.362649999999999 1.13737 130.2713048511448 63.21656803764717 107.11452987663783 371.10299357142856 102.1695 8.23841 887.506544785149 256.9746137822114 669.3144090412617 25.7745;6.67763;900.118;37.6554;140.856;122.514;8.00432;12.5403;27.5708;166.899;229.313;83.0393;32.8011;2.87451 8.17372;1.48195;487.466;13.2791;93.5219;84.8469;2.69961;3.74981;12.6303;105.26;185.32;63.0271;15.4462;1.13737 103.274;37.9425;3428.38;101.065;282.925;216.573;25.2254;51.2968;61.9858;384.658;299.27;119.986;74.622;8.23841 7 7 7 361042;64194;24426;25315;25426;24296;290277 PCK2_9440;INSIG1_8906;GSTP1_8762;EPHX1_8567;CYP1B1_32710;CYP1A1_8415;CRYL1_8388 77.08160428571429 37.6554 77.67155478906113 53.71879285714285 15.4462 65.69068107040519 130.20632857142857 101.065 94.20869673366526 6.67763;37.6554;122.514;27.5708;229.313;83.0393;32.8011 1.48195;13.2791;84.8469;12.6303;185.32;63.0271;15.4462 37.9425;101.065;216.573;61.9858;299.27;119.986;74.622 7 299270;24539;84029;24404;24890;171142;24207 SERPINA6_32325;LPL_32544;HAO2_8778;GPX1_33050;ESR1_33192;EHHADH_8534;APOC3_32553 179.58094714285716 25.7745 324.8222084835187 100.28691571428571 8.17372 176.60516629361092 611.9996585714287 103.274 1249.9329152211137 25.7745;900.118;140.856;8.00432;12.5403;166.899;2.87451 8.17372;487.466;93.5219;2.69961;3.74981;105.26;1.13737 103.274;3428.38;282.925;25.2254;51.2968;384.658;8.23841 0 Exp 2,1(0.08);Exp 4,1(0.08);Exp 5,1(0.08);Hill,6(0.43);Linear,1(0.08);Poly 2,4(0.29) 2.3363019668703426 36.684919595718384 1.5039241313934326 6.292444229125977 1.5040167209658595 1.9931259751319885 6.255203070105281 250.4073483584662 8.762571674379032 145.2431368970495 -93.8013651033512 836.0073522462085 CONFLICT 0.5 0.5 0.0 GO:0045185 4 maintenance of protein location 25 26 2 2 2 2 2 2 67 24 2454 0.96831 0.15528 0.15528 7.69 59107;64194 ltbp1;insig1 LTBP1_33264;INSIG1_8906 403.5247 403.5247 37.6554 517.4173261159507 205.148494445972 434.7579228777229 225.65305 225.65305 13.2791 300.34212038474556 110.50280820731373 252.36131420520218 1156.1325 1156.1325 101.065 1492.0907677190753 584.0695057739896 1253.7235422479882 0.5 403.5247 769.394;37.6554 438.027;13.2791 2211.2;101.065 1 1 1 64194 INSIG1_8906 37.6554 37.6554 13.2791 13.2791 101.065 101.065 37.6554 13.2791 101.065 1 59107 LTBP1_33264 769.394 769.394 438.027 438.027 2211.2 2211.2 769.394 438.027 2211.2 0 Exp 2,1(0.5);Exp 5,1(0.5) 1.725520454368772 3.480579376220703 1.5140434503555298 1.9665359258651733 0.31996049786875674 1.7402896881103516 -313.579128 1120.628528 -190.5998919999999 641.905992 -911.7998 3224.0648 CONFLICT 0.5 0.5 0.0 GO:0019438 5 aromatic compound biosynthetic process 165 183 7 7 7 5 5 5 64 178 2300 0.62406 0.56061 1.0 2.73 83472;116682;499709;24890;25748 ugdh;kynu;gar1;esr1;alas2 UGDH_10131;KYNU_8979;GAR1_8683;ESR1_33192;ALAS2_8019 499709(-0.07184) 212.63150000000002 100.381 12.5403 311.94189545421756 127.61084212405632 230.19375899796717 154.947862 72.7231 3.74981 243.8620266247755 89.40186395633543 179.5213112379108 389.35856 161.456 51.2968 547.8628144362127 240.4650916139564 402.6674816469843 59.3662;100.381;765.364;12.5403;125.506 25.4417;72.7231;587.034;3.74981;85.7907 135.068;161.456;1362.21;51.2968;236.762 2 3 2 83472;499709 UGDH_10131;GAR1_8683 412.36510000000004 412.36510000000004 499.21583188278396 306.23785 306.23785 397.10572359215 748.639 748.639 867.7204296788223 59.3662;765.364 25.4417;587.034 135.068;1362.21 3 116682;24890;25748 KYNU_8979;ESR1_33192;ALAS2_8019 79.47576666666667 100.381 59.31343801924934 54.08787 72.7231 44.08095683923729 149.83826666666667 161.456 93.27681329576679 100.381;12.5403;125.506 72.7231;3.74981;85.7907 161.456;51.2968;236.762 0 Exp 2,1(0.2);Hill,2(0.4);Poly 2,2(0.4) 1.723301192043806 8.641610860824585 1.5737498998641968 1.957481861114502 0.14924507239283966 1.7318620681762695 -60.79762704017912 486.06062704017916 -58.80662891623379 368.70235291623374 -90.86437020610009 869.5814902061002 DOWN 0.4 0.6 0.0 GO:0042594 4 response to starvation 75 79 4 4 3 3 2 2 67 77 2401 0.63782 0.63901 1.0 2.53 361042;25612 pck2;asns PCK2_9440;ASNS_8091 6.366854999999999 6.366854999999999 6.05608 0.43950221984650345 6.5185327349652455 0.3836012652242446 2.112875 2.112875 1.48195 0.8922626918402456 1.8049439407676036 0.7787744453755708 26.138800000000003 26.138800000000003 14.3351 16.6929526261833 31.899747567240862 14.569750637365214 6.67763;6.05608 1.48195;2.7438 37.9425;14.3351 2 0 2 361042;25612 PCK2_9440;ASNS_8091 6.366854999999999 6.366854999999999 0.43950221984650345 2.112875 2.112875 0.8922626918402456 26.138800000000003 26.138800000000003 16.6929526261833 6.67763;6.05608 1.48195;2.7438 37.9425;14.3351 0 0 Hill,2(1) 2.324013738427958 5.0614235401153564 1.528982162475586 3.5324413776397705 1.4166595968732734 2.5307117700576782 5.7577359999999995 6.975973999999999 0.8762620000000003 3.349487999999999 3.0035480000000057 49.274052 UP 1.0 0.0 0.0 GO:0007162 6 negative regulation of cell adhesion 83 86 5 5 4 4 3 3 66 83 2395 0.79769 0.41442 0.50488 3.49 288001;84586;25426 kng1;fgl2;cyp1b1 KNG1L1_32433;FGL2_32918;CYP1B1_32710 288001(0.1788) 126.53152 146.406 3.87556 114.02524305999616 160.0349946040827 122.34428205419307 94.06356999999998 95.6156 1.25511 92.0422594818201 127.19182691132492 100.39177003538082 212.7328 299.27 13.8374 172.73163032901647 220.84888167988555 158.76940384432058 3.87556;146.406;229.313 1.25511;95.6156;185.32 13.8374;325.091;299.27 2 1 2 288001;25426 KNG1L1_32433;CYP1B1_32710 116.59428 116.59428 159.40834255733543 93.287555 93.287555 130.15353189735592 156.5537 156.5537 201.83132703170733 3.87556;229.313 1.25511;185.32 13.8374;299.27 1 84586 FGL2_32918 146.406 146.406 95.6156 95.6156 325.091 325.091 146.406 95.6156 325.091 0 Exp 4,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 2.026756260828746 6.419323801994324 1.5755720138549805 3.1843981742858887 0.9056399102558845 1.6593536138534546 -2.500189359198515 255.56322935919852 -10.09205164575441 198.2191916457544 17.268559594679658 408.1970404053203 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0072503 8 cellular divalent inorganic cation homeostasis 114 121 4 4 3 4 3 3 66 118 2360 0.58302 0.64593 1.0 2.48 24567;288001;24890 mt1;kng1;esr1 MT1A_9255;KNG1L1_32433;ESR1_33192 288001(0.1788) 278.2499533333333 12.5403 3.87556 467.74656869687294 99.60681222130472 312.48388401008714 181.74030666666667 3.74981 1.25511 310.4515629130139 62.88458373658135 207.51053058514634 351.20973333333336 51.2968 13.8374 552.2229486311605 142.7824858794385 368.25922977423915 818.334;3.87556;12.5403 540.216;1.25511;3.74981 988.495;13.8374;51.2968 1 2 1 288001 KNG1L1_32433 3.87556 3.87556 1.25511 1.25511 13.8374 13.8374 3.87556 1.25511 13.8374 2 24567;24890 MT1A_9255;ESR1_33192 415.43715 415.43715 569.7821895073985 271.982905 271.982905 379.33888082631086 519.8959 519.8959 662.6992025358263 818.334;12.5403 540.216;3.74981 988.495;51.2968 0 Exp 4,1(0.34);Hill,1(0.34);Poly 2,1(0.34) 1.8544460895885524 5.64460825920105 1.5755720138549805 2.3371741771698 0.4022576258941028 1.7318620681762695 -251.05511707200685 807.5550237386735 -169.56870843294394 533.0493217662772 -273.6893600346499 976.1088267013166 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0071280 7 cellular response to copper ion 11 12 3 3 2 3 2 2 67 10 2468 0.99649 0.040069 0.040069 16.67 24567;24296 mt1;cyp1a1 MT1A_9255;CYP1A1_8415 450.68665 450.68665 83.0393 519.9318685405281 173.98629392971247 342.34919866299845 301.62155 301.62155 63.0271 337.4235070969492 122.04955180282977 222.1765470713684 554.2405 554.2405 119.986 614.1286034215473 227.40997946143315 404.37304958352365 0.0 83.0393 0.5 450.68665 818.334;83.0393 540.216;63.0271 988.495;119.986 1 1 1 24296 CYP1A1_8415 83.0393 83.0393 63.0271 63.0271 119.986 119.986 83.0393 63.0271 119.986 1 24567 MT1A_9255 818.334 818.334 540.216 540.216 988.495 988.495 818.334 540.216 988.495 0 Poly 2,2(1) 3.834910450531323 8.629618406295776 2.3371741771698 6.292444229125977 2.796798275162281 4.314809203147888 -269.9021559999999 1171.2754559999998 -166.023572 769.266672 -296.8983200000001 1405.37932 CONFLICT 0.5 0.5 0.0 GO:0009966 5 regulation of signal transduction 594 626 34 34 27 22 16 16 53 610 1868 0.45728 0.65318 0.8876 2.56 308843;192247;94195;338475;59107;64194;29200;25663;24426;24404;29739;25283;25317;24890;25426;24207 tsku;sez6;s100a9;nrep;ltbp1;insig1;inhba;il1r1;gstp1;gpx1;gclm;gclc;fgf1;esr1;cyp1b1;apoc3 TSKU_10094;SEZ6_9819;S100A9_9775;NREP_9364;LTBP1_33264;INSIG1_8906;INHBA_33300;IL1R1_8893;GSTP1_8762;GPX1_33050;GCLM_8700;GCLC_8699;FGF1_8633;ESR1_33192;CYP1B1_32710;APOC3_32553 226.15603937500003 107.40684999999999 2.87451 299.1439404891005 179.71723145599358 244.57677785986013 148.46041625 59.15435 1.13737 223.40002417386827 115.81605722168935 174.27202116279915 459.295331875 201.75150000000002 8.23841 620.9311941826918 365.4691996086836 513.7429095104623 92.2997;10.6392;963.318;191.159;769.394;37.6554;91.8104;76.6218;122.514;8.00432;190.233;145.958;674.162;12.5403;229.313;2.87451 49.0864;3.96047;802.143;115.886;438.027;13.2791;44.1594;27.5215;84.8469;2.69961;69.2223;96.7058;437.622;3.74981;185.32;1.13737 185.899;29.4997;1158.68;448.068;2211.2;101.065;186.93;185.143;216.573;25.2254;496.452;280.185;1465.0;51.2968;299.27;8.23841 9 7 9 308843;94195;64194;25663;24426;29739;25283;25317;25426 TSKU_10094;S100A9_9775;INSIG1_8906;IL1R1_8893;GSTP1_8762;GCLM_8700;GCLC_8699;FGF1_8633;CYP1B1_32710 281.3416555555555 145.958 318.39290884727285 196.1941111111111 84.8469 261.6167817045212 487.5852222222222 280.185 486.00351396203354 92.2997;963.318;37.6554;76.6218;122.514;190.233;145.958;674.162;229.313 49.0864;802.143;13.2791;27.5215;84.8469;69.2223;96.7058;437.622;185.32 185.899;1158.68;101.065;185.143;216.573;496.452;280.185;1465.0;299.27 7 192247;338475;59107;29200;24404;24890;24207 SEZ6_9819;NREP_9364;LTBP1_33264;INHBA_33300;GPX1_33050;ESR1_33192;APOC3_32553 155.2031042857143 12.5403 279.4830938992066 87.08852285714285 3.96047 160.30945207192886 422.9226157142857 51.2968 803.8733535763499 10.6392;191.159;769.394;91.8104;8.00432;12.5403;2.87451 3.96047;115.886;438.027;44.1594;2.69961;3.74981;1.13737 29.4997;448.068;2211.2;186.93;25.2254;51.2968;8.23841 0 Exp 2,1(0.07);Exp 4,2(0.13);Exp 5,1(0.07);Hill,6(0.38);Linear,2(0.13);Poly 2,4(0.25) 2.172450618048712 37.52153503894806 1.5140434503555298 5.5128583908081055 1.091044439852834 1.8467147946357727 79.5755085353407 372.73657021465925 38.994404404804555 257.92642809519543 155.03904672548106 763.5516170245189 CONFLICT 0.5625 0.4375 0.0 GO:2000379 7 positive regulation of reactive oxygen species metabolic process 59 62 5 5 4 4 3 3 66 59 2419 0.91495 0.23506 0.23506 4.84 24426;24890;25426 gstp1;esr1;cyp1b1 GSTP1_8762;ESR1_33192;CYP1B1_32710 121.45576666666666 122.514 12.5403 108.39022446541631 142.6308842621288 124.78643431729535 91.30556999999999 84.8469 3.74981 90.95723878716693 111.87454859976333 104.78603398319342 189.04659999999998 216.573 51.2968 126.25749087590809 203.12097667211356 142.59593519406636 122.514;12.5403;229.313 84.8469;3.74981;185.32 216.573;51.2968;299.27 2 1 2 24426;25426 GSTP1_8762;CYP1B1_32710 175.9135 175.9135 75.51829712394202 135.08345 135.08345 71.04521033683413 257.9215 257.9215 58.47560948378415 122.514;229.313 84.8469;185.32 216.573;299.27 1 24890 ESR1_33192 12.5403 12.5403 3.74981 3.74981 51.2968 51.2968 12.5403 3.74981 51.2968 0 Hill,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 3.12108671044749 10.429118633270264 1.7318620681762695 5.5128583908081055 1.9073332741131115 3.1843981742858887 -1.1993188676921847 244.11085220102552 -11.622235145091139 194.23337514509112 46.17279916495204 331.92040083504793 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0046173 6 polyol biosynthetic process 14 16 2 2 2 2 2 2 67 14 2464 0.99172 0.067982 0.067982 12.5 361042;25315 pck2;ephx1 PCK2_9440;EPHX1_8567 17.124215 17.124215 6.67763 14.773702187483336 16.931369928124518 14.77118471487499 7.056125 7.056125 1.48195 7.883073884041047 6.953225135736078 7.881730590239616 49.964150000000004 49.964150000000004 37.9425 17.001180472102497 49.742229060447805 16.998283432105044 0.0 6.67763 0.5 17.124215 6.67763;27.5708 1.48195;12.6303 37.9425;61.9858 2 0 2 361042;25315 PCK2_9440;EPHX1_8567 17.124215 17.124215 14.773702187483336 7.056125 7.056125 7.883073884041047 49.964150000000004 49.964150000000004 17.001180472102497 6.67763;27.5708 1.48195;12.6303 37.9425;61.9858 0 0 Hill,2(1) 2.173917019050249 4.6198718547821045 1.528982162475586 3.0908896923065186 1.1044354059297823 2.3099359273910522 -3.3510915999999966 37.599521599999996 -3.8692579999999994 17.981508 26.401716000000008 73.526584 UP 1.0 0.0 0.0 GO:0019725 4 cellular homeostasis 217 230 18 18 14 15 12 12 57 218 2260 0.99258 0.018537 0.029241 5.22 361042;24567;288001;25663;116686;24404;29739;25283;24890;117517;24207;25748 pck2;mt1;kng1;il1r1;gsr;gpx1;gclm;gclc;esr1;c7;apoc3;alas2 PCK2_9440;MT1A_9255;KNG1L1_32433;IL1R1_8893;GSR_8755;GPX1_33050;GCLM_8700;GCLC_8699;ESR1_33192;C7_8179;APOC3_32553;ALAS2_8019 288001(0.1788) 130.33625166666664 73.08685 2.87451 225.80124297787222 72.95093514987332 125.33713194039558 75.30109583333333 30.12645 1.13737 150.40508396762738 36.32317229773055 79.96710533364485 228.46420916666668 154.6775 8.23841 281.67947321700973 160.01719559088298 192.80989682046743 10.5 504.2835 6.67763;818.334;3.87556;76.6218;69.5519;8.00432;190.233;145.958;12.5403;103.858;2.87451;125.506 1.48195;540.216;1.25511;27.5215;41.1016;2.69961;69.2223;96.7058;3.74981;32.7314;1.13737;85.7907 37.9425;988.495;13.8374;185.143;124.212;25.2254;496.452;280.185;51.2968;293.781;8.23841;236.762 6 6 6 361042;288001;25663;116686;29739;25283 PCK2_9440;KNG1L1_32433;IL1R1_8893;GSR_8755;GCLM_8700;GCLC_8699 82.15298166666666 73.08685 74.51930677245794 39.54804333333333 34.31155 37.97367020366437 189.62865 154.6775 179.19360003196263 6.67763;3.87556;76.6218;69.5519;190.233;145.958 1.48195;1.25511;27.5215;41.1016;69.2223;96.7058 37.9425;13.8374;185.143;124.212;496.452;280.185 6 24567;24404;24890;117517;24207;25748 MT1A_9255;GPX1_33050;ESR1_33192;C7_8179;APOC3_32553;ALAS2_8019 178.51952166666663 58.19915 317.8751481729642 111.05414833333333 18.240605000000002 212.73890796744402 267.2997683333333 144.0294 372.59265763522666 818.334;8.00432;12.5403;103.858;2.87451;125.506 540.216;2.69961;3.74981;32.7314;1.13737;85.7907 988.495;25.2254;51.2968;293.781;8.23841;236.762 0 Exp 4,3(0.25);Hill,6(0.5);Poly 2,3(0.25) 1.767299514763183 21.34611403942108 1.5235437154769897 2.3371741771698 0.2199403695418926 1.7594949007034302 2.5771714183726147 258.09533191496075 -9.79859156854063 160.4007832352073 69.08904387337475 387.83937445995855 CONFLICT 0.5 0.5 0.0 GO:0000454 10 snoRNA guided rRNA pseudouridine synthesis 1 2 1 1 1 1 1 1 68 1 2477 0.99928 0.053458 0.053458 50.0 499709 gar1 GAR1_8683 499709(-0.07184) 765.364 765.364 765.364 765.364 587.034 587.034 587.034 587.034 1362.21 1362.21 1362.21 1362.21 0.0 765.364 0.0 765.364 765.364 587.034 1362.21 1 0 1 499709 GAR1_8683 765.364 765.364 587.034 587.034 1362.21 1362.21 765.364 587.034 1362.21 0 0 Exp 2,1(1) 1.619885802268982 1.619885802268982 1.619885802268982 1.619885802268982 0.0 1.619885802268982 765.364 765.364 587.034 587.034 1362.21 1362.21 UP 1.0 0.0 0.0 GO:0030162 7 regulation of proteolysis 214 230 11 11 7 9 5 5 64 225 2253 0.39779 0.76139 0.83051 2.17 299270;94195;288001;24404;25283 serpina6;s100a9;kng1;gpx1;gclc SERPINA6_32325;S100A9_9775;KNG1L1_32433;GPX1_33050;GCLC_8699 288001(0.1788) 229.386076 25.7745 3.87556 414.40887464219355 114.46270371225035 279.05271331320944 182.195448 8.17372 1.25511 348.88578744946716 85.09431604562738 233.84082442064746 316.24036 103.274 13.8374 482.8292823763571 184.76712424282155 331.63207177880514 25.7745;963.318;3.87556;8.00432;145.958 8.17372;802.143;1.25511;2.69961;96.7058 103.274;1158.68;13.8374;25.2254;280.185 3 2 3 94195;288001;25283 S100A9_9775;KNG1L1_32433;GCLC_8699 371.05052 145.958 517.8150546655158 300.0346366666667 96.7058 437.4497856352521 484.2341333333334 280.185 599.0769410553652 963.318;3.87556;145.958 802.143;1.25511;96.7058 1158.68;13.8374;280.185 2 299270;24404 SERPINA6_32325;GPX1_33050 16.889409999999998 16.889409999999998 12.565414780905565 5.436665 5.436665 3.8707803019610916 64.2497 64.2497 55.18869432211636 25.7745;8.00432 8.17372;2.69961 103.274;25.2254 0 Exp 4,1(0.2);Hill,2(0.4);Poly 2,2(0.4) 1.7634084973505593 8.845914483070374 1.5755720138549805 2.0197160243988037 0.16171551582990343 1.7603585720062256 -133.85931835822035 592.6314703582203 -123.61642815125614 488.00732415125617 -106.97816599302246 739.4588859930224 UP 0.6 0.4 0.0 GO:0002064 5 epithelial cell development 37 38 3 3 3 2 2 2 67 36 2442 0.91817 0.2752 0.2752 5.26 24404;24890 gpx1;esr1 GPX1_33050;ESR1_33192 10.272310000000001 10.272310000000001 8.00432 3.20742221732655 10.355118049488194 3.2052835965137034 3.22471 3.22471 2.69961 0.7426035416021101 3.243882265656485 0.7421083940093837 38.2611 38.2611 25.2254 18.435263735026957 38.73705487224954 18.422971608813928 0.5 10.272310000000001 8.00432;12.5403 2.69961;3.74981 25.2254;51.2968 0 2 0 2 24404;24890 GPX1_33050;ESR1_33192 10.272310000000001 10.272310000000001 3.20742221732655 3.22471 3.22471 0.7426035416021101 38.2611 38.2611 18.435263735026957 8.00432;12.5403 2.69961;3.74981 25.2254;51.2968 0 Hill,2(1) 1.7580516774763202 3.516499400138855 1.7318620681762695 1.7846373319625854 0.03731774690221282 1.7582497000694275 5.8270496000000005 14.717570400000001 2.1955139999999997 4.253906000000001 12.711128000000002 63.811071999999996 DOWN 0.0 1.0 0.0 GO:0009889 5 regulation of biosynthetic process 634 681 36 36 30 22 17 17 52 664 1814 0.4043 0.69926 0.78328 2.5 360243;94195;363465;259241;316351;59107;64194;29200;24426;25283;25317;24890;298452;24309;25426;289185;24207 top2a;s100a9;pir;nr1d2;npas2;ltbp1;insig1;inhba;gstp1;gclc;fgf1;esr1;dph2;dbp;cyp1b1;creg1;apoc3 TOP2A_10059;S100A9_9775;PIR_9487;NR1D2_9358;NPAS2_9350;LTBP1_33264;INSIG1_8906;INHBA_33300;GSTP1_8762;GCLC_8699;FGF1_8633;ESR1_33192;DPH2_8490;DBP_8439;CYP1B1_32710;CREG1_8380;APOC3_32553 244.82720117647088 97.6763 4.48597E-12 319.5005172373638 195.7099191374531 277.41247733492247 158.82670470588263 44.1594 4.48597E-12 233.2908986715364 125.85885321090826 192.07201794208405 526.0121064705884 280.185 4.48599E-12 679.9437823761374 426.6377765093743 605.1685619874936 4.48597E-12;963.318;152.213;9.46041;53.0014;769.394;37.6554;91.8104;122.514;145.958;674.162;12.5403;734.134;66.0377;229.313;97.6763;2.87451 4.48597E-12;802.143;56.4566;2.2133;14.3825;438.027;13.2791;44.1594;84.8469;96.7058;437.622;3.74981;463.289;19.9899;185.32;36.7323;1.13737 4.48599E-12;1158.68;371.778;49.4216;215.15;2211.2;101.065;186.93;216.573;280.185;1465.0;51.2968;1764.85;280.428;299.27;282.14;8.23841 11 6 11 360243;94195;363465;259241;64194;24426;25283;25317;24309;25426;289185 TOP2A_10059;S100A9_9775;PIR_9487;NR1D2_9358;INSIG1_8906;GSTP1_8762;GCLC_8699;FGF1_8633;DBP_8439;CYP1B1_32710;CREG1_8380 227.11889181818225 122.514 307.0079483250551 157.75535454545496 56.4566 248.43592453657462 409.50369090909135 280.428 465.6422151334333 4.48597E-12;963.318;152.213;9.46041;37.6554;122.514;145.958;674.162;66.0377;229.313;97.6763 4.48597E-12;802.143;56.4566;2.2133;13.2791;84.8469;96.7058;437.622;19.9899;185.32;36.7323 4.48599E-12;1158.68;371.778;49.4216;101.065;216.573;280.185;1465.0;280.428;299.27;282.14 6 316351;59107;29200;24890;298452;24207 NPAS2_9350;LTBP1_33264;INHBA_33300;ESR1_33192;DPH2_8490;APOC3_32553 277.292435 72.4059 369.0466393356197 160.79084666666665 29.27095 225.1907793935897 739.6108683333332 201.04000000000002 980.3965650336444 53.0014;769.394;91.8104;12.5403;734.134;2.87451 14.3825;438.027;44.1594;3.74981;463.289;1.13737 215.15;2211.2;186.93;51.2968;1764.85;8.23841 0 Exp 2,1(0.06);Exp 4,3(0.18);Exp 5,1(0.06);Hill,6(0.36);Linear,3(0.18);Poly 2,3(0.18) 2.0304790427772352 36.720893144607544 1.5140434503555298 5.5128583908081055 0.970593279293413 1.7603585720062256 92.94629618718321 396.7081061657584 47.92725101368835 269.72615839807685 202.78734958418528 849.2368633569915 UP 0.6470588235294118 0.35294117647058826 0.0 GO:0019369 6 arachidonic acid metabolic process 29 34 4 4 3 4 3 3 66 31 2447 0.9876 0.062612 0.062612 8.82 24404;25315;25426 gpx1;ephx1;cyp1b1 GPX1_33050;EPHX1_8567;CYP1B1_32710 88.29603999999999 27.5708 8.00432 122.51550530699696 102.0128584240327 125.4641629636945 66.88330333333333 12.6303 2.69961 102.6893031866174 77.95447571052216 105.63935364394823 128.82706666666664 61.9858 25.2254 148.74786349555862 146.31195830449823 151.32386600320447 0.5 17.78756 8.00432;27.5708;229.313 2.69961;12.6303;185.32 25.2254;61.9858;299.27 2 1 2 25315;25426 EPHX1_8567;CYP1B1_32710 128.4419 128.4419 142.6532776714927 98.97515 98.97515 122.11005791107054 180.62789999999998 180.62789999999998 167.785266888425 27.5708;229.313 12.6303;185.32 61.9858;299.27 1 24404 GPX1_33050 8.00432 8.00432 2.69961 2.69961 25.2254 25.2254 8.00432 2.69961 25.2254 0 Hill,2(0.67);Linear,1(0.34) 2.599482802955266 8.059925198554993 1.7846373319625854 3.1843981742858887 0.7825566519223839 3.0908896923065186 -50.343305539039534 226.93538553903954 -49.32058246853644 183.08718913520312 -39.49698663319654 297.1511199665299 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0002617 7 negative regulation of macrophage antigen processing and presentation 1 1 1 1 1 1 1 1 68 0 2478 1.0 0.027091 0.027091 100.0 84586 fgl2 FGL2_32918 146.406 146.406 146.406 146.406 95.6156 95.6156 95.6156 95.6156 325.091 325.091 325.091 325.091 0.0 146.406 0.0 146.406 146.406 95.6156 325.091 0 1 0 1 84586 FGL2_32918 146.406 146.406 95.6156 95.6156 325.091 325.091 146.406 95.6156 325.091 0 Poly 2,1(1) 1.6593536138534546 1.6593536138534546 1.6593536138534546 1.6593536138534546 0.0 1.6593536138534546 146.406 146.406 95.6156 95.6156 325.091 325.091 DOWN 0.0 1.0 0.0 GO:0043380 7 regulation of memory T cell differentiation 1 1 1 1 1 1 1 1 68 0 2478 1.0 0.027091 0.027091 100.0 84586 fgl2 FGL2_32918 146.406 146.406 146.406 146.406 95.6156 95.6156 95.6156 95.6156 325.091 325.091 325.091 325.091 0.0 146.406 0.0 146.406 146.406 95.6156 325.091 0 1 0 1 84586 FGL2_32918 146.406 146.406 95.6156 95.6156 325.091 325.091 146.406 95.6156 325.091 0 Poly 2,1(1) 1.6593536138534546 1.6593536138534546 1.6593536138534546 1.6593536138534546 0.0 1.6593536138534546 146.406 146.406 95.6156 95.6156 325.091 325.091 DOWN 0.0 1.0 0.0 GO:0043381 7 negative regulation of memory T cell differentiation 1 1 1 1 1 1 1 1 68 0 2478 1.0 0.027091 0.027091 100.0 84586 fgl2 FGL2_32918 146.406 146.406 146.406 146.406 95.6156 95.6156 95.6156 95.6156 325.091 325.091 325.091 325.091 0.0 146.406 0.0 146.406 146.406 95.6156 325.091 0 1 0 1 84586 FGL2_32918 146.406 146.406 95.6156 95.6156 325.091 325.091 146.406 95.6156 325.091 0 Poly 2,1(1) 1.6593536138534546 1.6593536138534546 1.6593536138534546 1.6593536138534546 0.0 1.6593536138534546 146.406 146.406 95.6156 95.6156 325.091 325.091 DOWN 0.0 1.0 0.0 GO:0043066 8 negative regulation of apoptotic process 279 296 13 13 10 8 6 6 63 290 2188 0.29252 0.83088 0.56832 2.03 24567;24426;24404;29739;25283;25612 mt1;gstp1;gpx1;gclm;gclc;asns MT1A_9255;GSTP1_8762;GPX1_33050;GCLM_8700;GCLC_8699;ASNS_8091 215.18323333333333 134.236 6.05608 304.77872288002715 137.32758474929045 208.1993704840006 132.73906833333334 77.03460000000001 2.69961 203.70219263774462 77.03648892958508 136.51940320475208 336.87758333333335 248.37900000000002 14.3351 365.7641947662807 260.404339126909 289.0095130603383 818.334;122.514;8.00432;190.233;145.958;6.05608 540.216;84.8469;2.69961;69.2223;96.7058;2.7438 988.495;216.573;25.2254;496.452;280.185;14.3351 4 2 4 24426;29739;25283;25612 GSTP1_8762;GCLM_8700;GCLC_8699;ASNS_8091 116.19027 134.236 78.60867845065368 63.3797 77.03460000000001 41.961561619415455 251.886275 248.37900000000002 198.57055825449677 122.514;190.233;145.958;6.05608 84.8469;69.2223;96.7058;2.7438 216.573;496.452;280.185;14.3351 2 24567;24404 MT1A_9255;GPX1_33050 413.16916 413.16916 572.9896117247251 271.457805 271.457805 380.08148436791294 506.8602 506.8602 681.1344662708532 818.334;8.00432 540.216;2.69961 988.495;25.2254 0 Hill,3(0.5);Poly 2,3(0.5) 2.546881719150517 16.836262106895447 1.7603585720062256 5.5128583908081055 1.4843265471505884 2.12298321723938 -28.69053613430657 459.0570028009732 -30.25663260654221 295.7347692732088 44.20527316993133 629.5498934967354 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0022607 5 cellular component assembly 355 395 19 18 15 6 4 4 65 391 2087 0.01161 0.99661 0.026478 1.01 83472;29685;312538;310395 ugdh;mcm6;mcm2;noct UGDH_10131;MCM6_9210;MCM2_9206;CCRN4L_8232 182.57130999999998 31.567415 1.87441 322.9061189277262 195.15015827908584 336.1955639302886 115.14519 13.1989515 0.496857 212.6799855537275 124.43996113192522 220.8411462883291 398.249925 78.99485000000001 9.53 687.1294902721194 424.23256204986154 716.0296646054899 59.3662;1.87441;3.76863;665.276 25.4417;0.496857;0.956203;433.686 135.068;9.53;22.9217;1425.48 4 0 4 83472;29685;312538;310395 UGDH_10131;MCM6_9210;MCM2_9206;CCRN4L_8232 182.57130999999998 31.567415 322.9061189277262 115.14519 13.1989515 212.6799855537275 398.249925 78.99485000000001 687.1294902721194 59.3662;1.87441;3.76863;665.276 25.4417;0.496857;0.956203;433.686 135.068;9.53;22.9217;1425.48 0 0 Hill,3(0.75);Linear,1(0.25) 1.66563855327844 6.68048632144928 1.5280487537384033 1.8211764097213745 0.14133495217526496 1.665630578994751 -133.8766865491716 499.0193065491716 -93.28119584265298 323.5715758426529 -275.1369754666769 1071.636825466677 UP 1.0 0.0 0.0 GO:0035999 6 tetrahydrofolate interconversion 3 3 1 1 1 1 1 1 68 2 2476 0.99787 0.07912 0.07912 33.33 680308 mthfd2 MTHFD2_9261 622.58 622.58 622.58 622.58 414.266 414.266 414.266 414.266 1250.29 1250.29 1250.29 1250.29 0.0 622.58 0.0 622.58 622.58 414.266 1250.29 1 0 1 680308 MTHFD2_9261 622.58 622.58 414.266 414.266 1250.29 1250.29 622.58 414.266 1250.29 0 0 Linear,1(1) 1.5278362035751343 1.5278362035751343 1.5278362035751343 1.5278362035751343 0.0 1.5278362035751343 622.58 622.58 414.266 414.266 1250.29 1250.29 UP 1.0 0.0 0.0 GO:0001775 3 cell activation 161 172 4 4 4 2 2 2 67 170 2308 0.14334 0.9539 0.32416 1.16 29739;84586 gclm;fgl2 GCLM_8700;FGL2_32918 168.3195 168.3195 146.406 30.990368899062894 182.5488628488932 23.568059536776996 82.41895 82.41895 69.2223 18.662881407890954 73.84980672120629 14.193051447099407 410.7715 410.7715 325.091 121.1705251309081 466.40747433429584 92.1497307660049 190.233;146.406 69.2223;95.6156 496.452;325.091 1 1 1 29739 GCLM_8700 190.233 190.233 69.2223 69.2223 496.452 496.452 190.233 69.2223 496.452 1 84586 FGL2_32918 146.406 146.406 95.6156 95.6156 325.091 325.091 146.406 95.6156 325.091 0 Hill,1(0.5);Poly 2,1(0.5) 1.7797082149220742 3.5681458711624146 1.6593536138534546 1.90879225730896 0.17637975627736127 1.7840729355812073 125.36904000000001 211.26996 56.553516 108.28438399999999 242.83772000000005 578.7052799999999 CONFLICT 0.5 0.5 0.0 GO:0033993 5 response to lipid 414 443 41 41 33 26 19 19 50 424 2054 0.98906 0.02247 0.034655 4.29 94195;361042;24614;59107;24539;170496;64194;29200;360504;24426;116686;24404;24890;25315;25426;24296;310395;24207;25748 s100a9;pck2;orm1;ltbp1;lpl;lcn2;insig1;inhba;hba-a2;gstp1;gsr;gpx1;esr1;ephx1;cyp1b1;cyp1a1;noct;apoc3;alas2 S100A9_9775;PCK2_9440;ORM1_9400;LTBP1_33264;LPL_32544;LCN2_32481;INSIG1_8906;INHBA_33300;HBA2_32600;GSTP1_8762;GSR_8755;GPX1_33050;ESR1_33192;EPHX1_8567;CYP1B1_32710;CYP1A1_8415;CCRN4L_8232;APOC3_32553;ALAS2_8019 309.5436610526316 122.514 2.87451 369.7036133429128 204.0224218178163 308.1562788626674 198.6061389473684 84.8469 1.13737 243.5757603362442 130.1318446207935 194.64820710418385 812.9094689473684 216.573 8.23841 1212.9857509108135 536.5861439616821 1043.344789891518 963.318;6.67763;662.49;769.394;900.118;972.626;37.6554;91.8104;131.05;122.514;69.5519;8.00432;12.5403;27.5708;229.313;83.0393;665.276;2.87451;125.506 802.143;1.48195;432.445;438.027;487.466;551.931;13.2791;44.1594;88.5948;84.8469;41.1016;2.69961;3.74981;12.6303;185.32;63.0271;433.686;1.13737;85.7907 1158.68;37.9425;1413.32;2211.2;3428.38;4084.57;101.065;186.93;254.163;216.573;124.212;25.2254;51.2968;61.9858;299.27;119.986;1425.48;8.23841;236.762 11 8 11 94195;361042;24614;170496;64194;24426;116686;25315;25426;24296;310395 S100A9_9775;PCK2_9440;ORM1_9400;LCN2_32481;INSIG1_8906;GSTP1_8762;GSR_8755;EPHX1_8567;CYP1B1_32710;CYP1A1_8415;CCRN4L_8232 349.09382090909094 122.514 386.84446496199524 238.35381363636364 84.8469 273.085666312478 822.0985727272728 216.573 1216.6839790726053 963.318;6.67763;662.49;972.626;37.6554;122.514;69.5519;27.5708;229.313;83.0393;665.276 802.143;1.48195;432.445;551.931;13.2791;84.8469;41.1016;12.6303;185.32;63.0271;433.686 1158.68;37.9425;1413.32;4084.57;101.065;216.573;124.212;61.9858;299.27;119.986;1425.48 8 59107;24539;29200;360504;24404;24890;24207;25748 LTBP1_33264;LPL_32544;INHBA_33300;HBA2_32600;GPX1_33050;ESR1_33192;APOC3_32553;ALAS2_8019 255.16219124999998 108.6582 363.1021480769447 143.95308625 64.97505 200.31853331966624 800.27445125 211.846 1291.6553465456543 769.394;900.118;91.8104;131.05;8.00432;12.5403;2.87451;125.506 438.027;487.466;44.1594;88.5948;2.69961;3.74981;1.13737;85.7907 2211.2;3428.38;186.93;254.163;25.2254;51.2968;8.23841;236.762 0 Exp 2,2(0.11);Exp 4,2(0.11);Exp 5,1(0.06);Hill,5(0.27);Linear,4(0.22);Poly 2,5(0.27) 2.1160032691664603 44.5145069360733 1.5140434503555298 6.292444229125977 1.3451114731318055 1.7846373319625854 143.30464254409256 475.78267956117054 89.08111979855413 308.1311580961827 267.4845571566806 1358.334380738056 CONFLICT 0.5789473684210527 0.42105263157894735 0.0 GO:0042743 5 hydrogen peroxide metabolic process 18 19 7 7 5 6 4 4 65 15 2463 0.99989 0.0014068 0.0014068 21.05 287167;360504;24404;24296 hba-a1;hba-a2;gpx1;cyp1a1 LOC287167_9118;HBA2_32600;GPX1_33050;CYP1A1_8415 92.843905 107.04465 8.00432 63.084202260566805 93.88223660641727 59.44118037088968 62.830977499999996 75.81095 2.69961 42.61173737731612 64.19865741102704 39.794987161020394 183.3816 187.0745 25.2254 137.56708157588673 181.90081507636262 134.00849740017784 0.0 8.00432 0.5 45.52181 149.282;131.05;8.00432;83.0393 97.0024;88.5948;2.69961;63.0271 334.152;254.163;25.2254;119.986 1 3 1 24296 CYP1A1_8415 83.0393 83.0393 63.0271 63.0271 119.986 119.986 83.0393 63.0271 119.986 3 287167;360504;24404 LOC287167_9118;HBA2_32600;GPX1_33050 96.11210666666666 131.05 76.84619710482842 62.76560333333333 88.5948 52.18826113964742 204.51346666666666 254.163 160.33626591340257 149.282;131.05;8.00432 97.0024;88.5948;2.69961 334.152;254.163;25.2254 0 Hill,1(0.25);Poly 2,3(0.75) 2.4850759972022387 11.768498420715332 1.743384599685669 6.292444229125977 2.2352938331751764 1.8663347959518433 31.021386784644562 154.66642321535545 21.07147487023022 104.59048012976977 48.56586005563099 318.197339944369 DOWN 0.25 0.75 0.0 GO:0022603 5 regulation of anatomical structure morphogenesis 271 280 5 5 5 3 3 3 66 277 2201 0.044545 0.98626 0.078835 1.07 25317;24890;25426 fgf1;esr1;cyp1b1 FGF1_8633;ESR1_33192;CYP1B1_32710 305.33843333333334 229.313 12.5403 337.29915262695715 316.02128810554524 321.8885147792036 208.89727000000002 185.32 3.74981 217.8948945233428 218.95635128014843 205.81264031150408 605.1889333333334 299.27 51.2968 754.8701741037418 611.3432159967017 734.1699404251632 674.162;12.5403;229.313 437.622;3.74981;185.32 1465.0;51.2968;299.27 2 1 2 25317;25426 FGF1_8633;CYP1B1_32710 451.7375 451.7375 314.55574450405453 311.471 311.471 178.40445510692828 882.135 882.135 824.295588032594 674.162;229.313 437.622;185.32 1465.0;299.27 1 24890 ESR1_33192 12.5403 12.5403 3.74981 3.74981 51.2968 51.2968 12.5403 3.74981 51.2968 0 Hill,1(0.34);Linear,2(0.67) 2.0536115206174146 6.486674427986145 1.5704141855239868 3.1843981742858887 0.8889010888305457 1.7318620681762695 -76.35148953721517 687.0283562038819 -37.67401497587031 455.46855497587035 -249.0270831818159 1459.4049498484826 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0052548 7 regulation of endopeptidase activity 137 148 7 7 5 6 4 4 65 144 2334 0.62714 0.5769 1.0 2.7 299270;94195;288001;24404 serpina6;s100a9;kng1;gpx1 SERPINA6_32325;S100A9_9775;KNG1L1_32433;GPX1_33050 288001(0.1788) 250.24309499999998 16.889409999999998 3.87556 475.47820023547865 105.69406691473907 325.14049857509207 203.56786 5.436665 1.25511 399.061219548657 81.86155123700972 272.95027287189964 325.2542 64.2497 13.8374 557.0372451489397 158.20173845122358 381.6438266748596 25.7745;963.318;3.87556;8.00432 8.17372;802.143;1.25511;2.69961 103.274;1158.68;13.8374;25.2254 2 2 2 94195;288001 S100A9_9775;KNG1L1_32433 483.59677999999997 483.59677999999997 678.4282554821673 401.699055 401.699055 566.3132579891858 586.2587 586.2587 809.5259658512382 963.318;3.87556 802.143;1.25511 1158.68;13.8374 2 299270;24404 SERPINA6_32325;GPX1_33050 16.889409999999998 16.889409999999998 12.565414780905565 5.436665 5.436665 3.8707803019610916 64.2497 64.2497 55.18869432211636 25.7745;8.00432 8.17372;2.69961 103.274;25.2254 0 Exp 4,1(0.25);Hill,2(0.5);Poly 2,1(0.25) 1.7641718039817984 7.085555911064148 1.5755720138549805 2.0197160243988037 0.1866460968067161 1.7451339364051819 -215.72554123076907 716.211731230769 -187.51213515768384 594.6478551576839 -220.642300245961 871.1507002459609 CONFLICT 0.5 0.5 0.0 GO:0009062 6 fatty acid catabolic process 37 42 4 4 4 2 2 2 67 40 2438 0.89671 0.3158 0.3158 4.76 361042;171142 pck2;ehhadh PCK2_9440;EHHADH_8534 86.788315 86.788315 6.67763 113.29361721799889 80.67713924808743 112.96349305946995 53.370975 53.370975 1.48195 73.3821628933166 49.41266467759562 73.16833597728149 211.30025 211.30025 37.9425 245.16488119248447 198.0758008743169 244.45049981697613 6.67763;166.899 1.48195;105.26 37.9425;384.658 1 1 1 361042 PCK2_9440 6.67763 6.67763 1.48195 1.48195 37.9425 37.9425 6.67763 1.48195 37.9425 1 171142 EHHADH_8534 166.899 166.899 105.26 105.26 384.658 384.658 166.899 105.26 384.658 0 Hill,1(0.5);Poly 2,1(0.5) 1.5164013883590148 3.0329062938690186 1.5039241313934326 1.528982162475586 0.017718703701373895 1.5164531469345093 -70.2286276 243.8052576 -48.331514 155.073464 -128.48094000000003 551.08144 CONFLICT 0.5 0.5 0.0 GO:0000290 9 deadenylation-dependent decapping of nuclear-transcribed mRNA 3 3 1 1 1 1 1 1 68 2 2476 0.99787 0.07912 0.07912 33.33 310395 noct CCRN4L_8232 665.276 665.276 665.276 665.276 433.686 433.686 433.686 433.68600000000004 1425.48 1425.48 1425.48 1425.48 0.0 665.276 0.0 665.276 665.276 433.686 1425.48 1 0 1 310395 CCRN4L_8232 665.276 665.276 433.686 433.686 1425.48 1425.48 665.276 433.686 1425.48 0 0 Linear,1(1) 1.7575112581253052 1.7575112581253052 1.7575112581253052 1.7575112581253052 0.0 1.7575112581253052 665.276 665.276 433.686 433.686 1425.48 1425.48 UP 1.0 0.0 0.0 GO:0006807 3 nitrogen compound metabolic process 1028 1128 65 64 55 47 38 38 31 1090 1388 0.97413 0.044475 0.084738 3.37 83472;360243;266730;171497;94195;291317;293656;287877;293820;58835;680308;313108;29685;312538;116682;293502;29200;84029;24426;300850;116686;24404;29739;25283;499709;84586;24890;171142;298452;25426;24296;310395;81508;25612;24207;25748;360887;296925 ugdh;top2a;slc17a3;sgk2;s100a9;rpp38;rgd1307603;pycr1;psat1;phgdh;mthfd2;mms22l;mcm6;mcm2;kynu;kif22;inhba;hao2;gstp1;gsta4;gsr;gpx1;gclm;gclc;gar1;fgl2;esr1;ehhadh;dph2;cyp1b1;cyp1a1;noct;bhmt;asns;apoc3;alas2;coq8a;aass UGDH_10131;TOP2A_10059;SLC17A3_9840;SGK2_32380;S100A9_9775;RPP38_9741;RGD1307603_9684;PYCR1_9631;PSAT1_9583;PHGDH_9470;MTHFD2_9261;MMS22L_33129;MCM6_9210;MCM2_9206;KYNU_8979;KIF22_8963;INHBA_33300;HAO2_8778;GSTP1_8762;GSTA4_8757;GSR_8755;GPX1_33050;GCLM_8700;GCLC_8699;GAR1_8683;FGL2_32918;ESR1_33192;EHHADH_8534;DPH2_8490;CYP1B1_32710;CYP1A1_8415;CCRN4L_8232;BHMT_8143;ASNS_8091;APOC3_32553;ALAS2_8019;ADCK3_7987;AASS_7936 499709(-0.07184) 205.79012436842117 111.44749999999999 4.48597E-12 275.93227363134326 169.48853311585444 244.780650216807 144.67057134210538 69.07375 4.48597E-12 212.71443291810652 118.30226079249233 185.55821412248156 372.42310210526324 201.75150000000002 4.48599E-12 473.58701758546965 308.58307794213897 435.82791768132734 59.3662;4.48597E-12;93.3839;156.37;963.318;916.962;32.0155;132.668;27.1579;122.826;622.58;4.13516;1.87441;3.76863;100.381;0.961856;91.8104;140.856;122.514;339.498;69.5519;8.00432;190.233;145.958;765.364;146.406;12.5403;166.899;734.134;229.313;83.0393;665.276;5.5396;6.05608;2.87451;125.506;525.072;5.81076 25.4417;4.48597E-12;68.9252;100.616;802.143;769.912;12.3892;90.3184;10.0144;67.6778;414.266;1.24709;0.496857;0.956203;72.7231;0.281971;44.1594;93.5219;84.8469;260.156;41.1016;2.69961;69.2223;96.7058;587.034;95.6156;3.74981;105.26;463.289;185.32;63.0271;433.686;1.97501;2.7438;1.13737;85.7907;336.426;2.60489 135.068;4.48599E-12;143.418;343.205;1158.68;1051.72;78.5761;239.858;103.876;246.456;1250.29;20.8956;9.53;22.9217;161.456;4.47267;186.93;282.925;216.573;486.944;124.212;25.2254;496.452;280.185;1362.21;325.091;51.2968;384.658;1764.85;299.27;119.986;1425.48;37.8319;14.3351;8.23841;236.762;1038.12;14.0792 23 15 23 83472;360243;266730;171497;94195;287877;293820;58835;680308;313108;29685;312538;293502;24426;300850;116686;29739;25283;499709;25426;24296;310395;25612 UGDH_10131;TOP2A_10059;SLC17A3_9840;SGK2_32380;S100A9_9775;PYCR1_9631;PSAT1_9583;PHGDH_9470;MTHFD2_9261;MMS22L_33129;MCM6_9210;MCM2_9206;KIF22_8963;GSTP1_8762;GSTA4_8757;GSR_8755;GCLM_8700;GCLC_8699;GAR1_8683;CYP1B1_32710;CYP1A1_8415;CCRN4L_8232;ASNS_8091 208.92231895652193 122.514 274.8815561074621 148.09687482608715 68.9252 213.2741968809777 369.7529595652176 216.573 460.44415610541085 59.3662;4.48597E-12;93.3839;156.37;963.318;132.668;27.1579;122.826;622.58;4.13516;1.87441;3.76863;0.961856;122.514;339.498;69.5519;190.233;145.958;765.364;229.313;83.0393;665.276;6.05608 25.4417;4.48597E-12;68.9252;100.616;802.143;90.3184;10.0144;67.6778;414.266;1.24709;0.496857;0.956203;0.281971;84.8469;260.156;41.1016;69.2223;96.7058;587.034;185.32;63.0271;433.686;2.7438 135.068;4.48599E-12;143.418;343.205;1158.68;239.858;103.876;246.456;1250.29;20.8956;9.53;22.9217;4.47267;216.573;486.944;124.212;496.452;280.185;1362.21;299.27;119.986;1425.48;14.3351 15 291317;293656;116682;29200;84029;24404;84586;24890;171142;298452;81508;24207;25748;360887;296925 RPP38_9741;RGD1307603_9684;KYNU_8979;INHBA_33300;HAO2_8778;GPX1_33050;FGL2_32918;ESR1_33192;EHHADH_8534;DPH2_8490;BHMT_8143;APOC3_32553;ALAS2_8019;ADCK3_7987;AASS_7936 200.98742600000003 100.381 287.13363680165895 139.416906 72.7231 219.21637337277957 376.51732066666665 186.93 509.4761355785053 916.962;32.0155;100.381;91.8104;140.856;8.00432;146.406;12.5403;166.899;734.134;5.5396;2.87451;125.506;525.072;5.81076 769.912;12.3892;72.7231;44.1594;93.5219;2.69961;95.6156;3.74981;105.26;463.289;1.97501;1.13737;85.7907;336.426;2.60489 1051.72;78.5761;161.456;186.93;282.925;25.2254;325.091;51.2968;384.658;1764.85;37.8319;8.23841;236.762;1038.12;14.0792 0 Exp 2,2(0.06);Exp 4,7(0.19);Hill,11(0.29);Linear,5(0.14);Poly 2,13(0.35) 1.9427554783713368 78.91586482524872 1.5039241313934326 6.292444229125977 1.0107567831070468 1.75807124376297 118.05635826235606 293.5238904744863 77.03716964022644 212.30397304398443 221.84422242254644 523.0019817879802 UP 0.6052631578947368 0.39473684210526316 0.0 GO:2001236 7 regulation of extrinsic apoptotic signaling pathway 62 65 6 6 6 5 5 5 64 60 2418 0.99256 0.029624 0.029624 7.69 29200;24426;24404;29739;25283 inhba;gstp1;gpx1;gclm;gclc INHBA_33300;GSTP1_8762;GPX1_33050;GCLM_8700;GCLC_8699 111.703944 122.514 8.00432 68.20259417728683 106.43607517286006 77.15498670215304 59.526801999999996 69.2223 2.69961 37.35931855413077 53.307676149473096 39.99782077656403 241.07308000000003 216.573 25.2254 170.9313334790669 239.1365470419671 191.44236788700832 2.5 134.236 91.8104;122.514;8.00432;190.233;145.958 44.1594;84.8469;2.69961;69.2223;96.7058 186.93;216.573;25.2254;496.452;280.185 3 2 3 24426;29739;25283 GSTP1_8762;GCLM_8700;GCLC_8699 152.90166666666667 145.958 34.38933875975705 83.59166666666668 84.8469 13.784679941998307 331.07 280.185 146.71409638817943 122.514;190.233;145.958 84.8469;69.2223;96.7058 216.573;496.452;280.185 2 29200;24404 INHBA_33300;GPX1_33050 49.90736 49.90736 59.2598474726623 23.429505 23.429505 29.316498655570207 106.07770000000001 106.07770000000001 114.34241920905819 91.8104;8.00432 44.1594;2.69961 186.93;25.2254 0 Hill,3(0.6);Poly 2,2(0.4) 2.3763961999032945 13.259137511253357 1.7603585720062256 5.5128583908081055 1.6134944620865423 1.90879225730896 51.92173436568007 171.48615363431992 26.779915454998623 92.27368854500139 91.24516019159927 390.90099980840074 UP 0.6 0.4 0.0 GO:0010951 8 negative regulation of endopeptidase activity 84 91 5 5 4 4 3 3 66 88 2390 0.7688 0.45097 0.73574 3.3 299270;288001;24404 serpina6;kng1;gpx1 SERPINA6_32325;KNG1L1_32433;GPX1_33050 288001(0.1788) 12.55146 8.00432 3.87556 11.636075580521121 13.33946587696497 11.654022665322389 4.042813333333333 2.69961 1.25511 3.64964895284921 4.296894667656888 3.647080094587472 47.445600000000006 25.2254 13.8374 48.68294692107288 50.463641217972516 49.07335517455858 25.7745;3.87556;8.00432 8.17372;1.25511;2.69961 103.274;13.8374;25.2254 1 2 1 288001 KNG1L1_32433 3.87556 3.87556 1.25511 1.25511 13.8374 13.8374 3.87556 1.25511 13.8374 2 299270;24404 SERPINA6_32325;GPX1_33050 16.889409999999998 16.889409999999998 12.565414780905565 5.436665 5.436665 3.8707803019610916 64.2497 64.2497 55.18869432211636 25.7745;8.00432 8.17372;2.69961 103.274;25.2254 0 Exp 4,1(0.34);Hill,2(0.67) 1.7841287059921114 5.37992537021637 1.5755720138549805 2.0197160243988037 0.22219893525656537 1.7846373319625854 -0.6159990827004158 25.718919082700417 -0.08715324520191547 8.17277991186858 -7.644340519258357 102.53554051925835 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0051241 5 negative regulation of multicellular organismal process 326 344 18 18 16 11 9 9 60 335 2143 0.54215 0.60007 1.0 2.62 192247;24614;288001;29200;24426;84586;310395;24207;114628 sez6;orm1;kng1;inhba;gstp1;fgl2;noct;apoc3;abcg5 SEZ6_9819;ORM1_9400;KNG1L1_32433;INHBA_33300;GSTP1_8762;FGL2_32918;CCRN4L_8232;APOC3_32553;ABCG5_7947 288001(0.1788) 252.36096333333333 122.514 2.87451 290.0336182333226 278.3188287214476 308.11663992850566 164.88409444444443 84.8469 1.13737 193.12398402991653 183.69316651981467 206.94616499471368 518.5455011111111 216.573 8.23841 601.6955615950042 558.4774717587836 623.478985998293 10.6392;662.49;3.87556;91.8104;122.514;146.406;665.276;2.87451;565.363 3.96047;432.445;1.25511;44.1594;84.8469;95.6156;433.686;1.13737;386.851 29.4997;1413.32;13.8374;186.93;216.573;325.091;1425.48;8.23841;1047.94 4 5 4 24614;288001;24426;310395 ORM1_9400;KNG1L1_32433;GSTP1_8762;CCRN4L_8232 363.53889 392.502 350.175079194958 238.05825249999998 258.64594999999997 227.74684046714898 767.3026 814.9465 757.5286289201044 662.49;3.87556;122.514;665.276 432.445;1.25511;84.8469;433.686 1413.32;13.8374;216.573;1425.48 5 192247;29200;84586;24207;114628 SEZ6_9819;INHBA_33300;FGL2_32918;APOC3_32553;ABCG5_7947 163.418622 91.8104 232.4287059808049 106.344768 44.1594 161.41330668580943 319.539822 186.93 426.9703857592057 10.6392;91.8104;146.406;2.87451;565.363 3.96047;44.1594;95.6156;1.13737;386.851 29.4997;186.93;325.091;8.23841;1047.94 0 Exp 4,2(0.23);Hill,2(0.23);Linear,3(0.34);Poly 2,2(0.23) 2.1335176336003077 21.401426553726196 1.5235437154769897 5.5128583908081055 1.370547981689423 1.7575112581253052 62.87233275422926 441.84959391243746 38.70975821156567 291.05843067732326 125.43773420237511 911.6532680198468 CONFLICT 0.4444444444444444 0.5555555555555556 0.0 GO:0046165 5 alcohol biosynthetic process 38 41 9 9 9 3 3 3 66 38 2440 0.9765 0.097729 0.097729 7.32 361042;64194;25315 pck2;insig1;ephx1 PCK2_9440;INSIG1_8906;EPHX1_8567 23.967943333333334 27.5708 6.67763 15.800031350083874 21.590704731441402 15.463703023614611 9.13045 12.6303 1.48195 6.631734279017819 8.375456661856663 6.82476588864519 66.99776666666666 61.9858 37.9425 31.85831695120338 61.28100660573995 29.267262490045557 1.5 32.6131 6.67763;37.6554;27.5708 1.48195;13.2791;12.6303 37.9425;101.065;61.9858 3 0 3 361042;64194;25315 PCK2_9440;INSIG1_8906;EPHX1_8567 23.967943333333334 27.5708 15.800031350083874 9.13045 12.6303 6.631734279017819 66.99776666666666 61.9858 31.85831695120338 6.67763;37.6554;27.5708 1.48195;13.2791;12.6303 37.9425;101.065;61.9858 0 0 Exp 5,1(0.34);Hill,2(0.67) 2.102467397196054 6.586407780647278 1.528982162475586 3.0908896923065186 0.8057273959710562 1.9665359258651733 6.088524721109447 41.847361945557225 1.625936200477386 16.634963799522613 30.946687245963503 103.04884608736982 UP 1.0 0.0 0.0 GO:0045471 5 response to ethanol 109 117 11 11 9 5 4 4 65 113 2365 0.79171 0.39195 0.55655 3.42 94195;24426;116686;54232 s100a9;gstp1;gsr;car3 S100A9_9775;GSTP1_8762;GSR_8755;CAR3_8196 289.7083075 96.03295 3.44933 451.7067633812156 182.90508199904312 363.99164380571017 232.5557325 62.97425 2.13143 381.22504225656905 141.76319389602105 307.2643657978969 376.37153250000006 170.3925 6.02113 528.6101146005068 248.4410169563831 428.050350350141 963.318;122.514;69.5519;3.44933 802.143;84.8469;41.1016;2.13143 1158.68;216.573;124.212;6.02113 3 1 3 94195;24426;116686 S100A9_9775;GSTP1_8762;GSR_8755 385.1279666666667 122.514 501.4269956769413 309.36383333333333 84.8469 427.31942752880235 499.8216666666667 216.573 572.453811352788 963.318;122.514;69.5519 802.143;84.8469;41.1016 1158.68;216.573;124.212 1 54232 CAR3_8196 3.44933 3.44933 2.13143 2.13143 6.02113 6.02113 3.44933 2.13143 6.02113 0 Exp 4,2(0.5);Poly 2,2(0.5) 3.2761450872471354 15.790226697921753 1.7056305408477783 6.759152412414551 2.5780855549083666 3.662721872329712 -152.96432061359144 732.3809356135913 -141.04480891143768 606.1562739114377 -141.66637980849657 894.4094448084967 UP 0.75 0.25 0.0 GO:1903202 7 negative regulation of oxidative stress-induced cell death 25 26 3 3 2 3 2 2 67 24 2454 0.96831 0.15528 0.15528 7.69 287877;24404 pycr1;gpx1 PYCR1_9631;GPX1_33050 70.33616 70.33616 8.00432 88.15053349566978 83.32918293206198 86.21414771222308 46.509005 46.509005 2.69961 61.95584056836005 55.64103886703747 60.59486855695466 132.5417 132.5417 25.2254 151.7681669236998 154.91169817242752 148.43430484531254 0.5 70.33616 132.668;8.00432 90.3184;2.69961 239.858;25.2254 1 1 1 287877 PYCR1_9631 132.668 132.668 90.3184 90.3184 239.858 239.858 132.668 90.3184 239.858 1 24404 GPX1_33050 8.00432 8.00432 2.69961 2.69961 25.2254 25.2254 8.00432 2.69961 25.2254 0 Hill,1(0.5);Poly 2,1(0.5) 1.7746142615760636 3.549284815788269 1.7646474838256836 1.7846373319625854 0.014134957172492576 1.7746424078941345 -51.83424639999997 192.5065664 -39.35740919999998 132.37541919999998 -77.798248 342.881648 CONFLICT 0.5 0.5 0.0 GO:0043010 7 camera-type eye development 12 12 2 2 2 2 2 2 67 10 2468 0.99649 0.040069 0.040069 16.67 308843;24296 tsku;cyp1a1 TSKU_10094;CYP1A1_8415 87.6695 87.6695 83.0393 6.548091636499983 85.88927023363138 6.044755415884951 56.056749999999994 56.056749999999994 49.0864 9.857563504487379 58.73672593019902 9.099836057430183 152.9425 152.9425 119.986 46.60752926834889 140.27131035477356 43.02491941246857 0.0 83.0393 0.5 87.6695 92.2997;83.0393 49.0864;63.0271 185.899;119.986 2 0 2 308843;24296 TSKU_10094;CYP1A1_8415 87.6695 87.6695 6.548091636499983 56.056749999999994 56.056749999999994 9.857563504487379 152.9425 152.9425 46.60752926834889 92.2997;83.0393 49.0864;63.0271 185.899;119.986 0 0 Exp 4,1(0.5);Poly 2,1(0.5) 4.580314377684736 9.626487255096436 3.334043025970459 6.292444229125977 2.0919055522217076 4.813243627548218 78.594308 96.744692 42.394864 69.71863599999999 88.34776 217.53724 UP 1.0 0.0 0.0 GO:0009888 4 tissue development 153 164 8 8 7 6 5 5 64 159 2319 0.71743 0.46084 0.80124 3.05 58835;24404;25317;24890;25426 phgdh;gpx1;fgf1;esr1;cyp1b1 PHGDH_9470;GPX1_33050;FGF1_8633;ESR1_33192;CYP1B1_32710 209.369124 122.826 8.00432 275.3222013973426 234.8299913648838 278.23200875093266 139.413844 67.6778 2.69961 182.53564814286725 159.55365045281434 183.67882654323543 417.44964 246.456 25.2254 597.5940858247243 457.26653284234106 610.5874164308585 122.826;8.00432;674.162;12.5403;229.313 67.6778;2.69961;437.622;3.74981;185.32 246.456;25.2254;1465.0;51.2968;299.27 3 2 3 58835;25317;25426 PHGDH_9470;FGF1_8633;CYP1B1_32710 342.1003333333333 229.313 292.4612506714922 230.20659999999998 185.32 189.0126528121332 670.2420000000001 299.27 688.7870052287572 122.826;674.162;229.313 67.6778;437.622;185.32 246.456;1465.0;299.27 2 24404;24890 GPX1_33050;ESR1_33192 10.272310000000001 10.272310000000001 3.20742221732655 3.22471 3.22471 0.7426035416021101 38.2611 38.2611 18.435263735026957 8.00432;12.5403 2.69961;3.74981 25.2254;51.2968 0 Exp 4,1(0.2);Hill,2(0.4);Linear,2(0.4) 1.9443356839661405 10.069153189659119 1.5704141855239868 3.1843981742858887 0.6605932355336378 1.7846373319625854 -31.96142595142345 450.69967395142345 -20.585706085258295 299.41339408525835 -106.36467155152337 941.2639515515234 UP 0.6 0.4 0.0 GO:0036315 6 cellular response to sterol 9 9 4 4 4 2 2 2 67 7 2471 0.99858 0.023028 0.023028 22.22 64194;29200 insig1;inhba INSIG1_8906;INHBA_33300 64.7329 64.7329 37.6554 38.29336773515746 60.78646015728731 37.8844722496658 28.71925 28.71925 13.2791 21.835669535074942 26.468908456745993 21.602508880276158 143.9975 143.9975 101.065 60.715723766582926 137.7402558472066 60.0674030046636 0.0 37.6554 0.0 37.6554 37.6554;91.8104 13.2791;44.1594 101.065;186.93 1 1 1 64194 INSIG1_8906 37.6554 37.6554 13.2791 13.2791 101.065 101.065 37.6554 13.2791 101.065 1 29200 INHBA_33300 91.8104 91.8104 44.1594 44.1594 186.93 186.93 91.8104 44.1594 186.93 0 Exp 5,1(0.5);Hill,1(0.5) 2.1232677247403258 4.259026885032654 1.9665359258651733 2.2924909591674805 0.23048501440994829 2.129513442516327 11.661000000000001 117.8048 -1.5434439999999974 58.981944 59.8498 228.1452 CONFLICT 0.5 0.5 0.0 GO:0006518 5 peptide metabolic process 59 74 11 11 10 9 8 8 61 66 2412 0.99987 6.9613E-4 6.9613E-4 10.81 293656;84029;24426;300850;116686;24404;29739;25283 rgd1307603;hao2;gstp1;gsta4;gsr;gpx1;gclm;gclc RGD1307603_9684;HAO2_8778;GSTP1_8762;GSTA4_8757;GSR_8755;GPX1_33050;GCLM_8700;GCLC_8699 131.07884 131.685 8.00432 104.24870454526219 136.49221573865537 112.50463622516038 82.58041375 77.03460000000001 2.69961 80.23550063810602 85.97556667047607 86.98912290674295 248.8865625 248.37900000000002 25.2254 175.54652574779095 257.2983400462705 187.64138648849993 2.5 96.03295 6.5 264.8655 32.0155;140.856;122.514;339.498;69.5519;8.00432;190.233;145.958 12.3892;93.5219;84.8469;260.156;41.1016;2.69961;69.2223;96.7058 78.5761;282.925;216.573;486.944;124.212;25.2254;496.452;280.185 5 3 5 24426;300850;116686;29739;25283 GSTP1_8762;GSTA4_8757;GSR_8755;GCLM_8700;GCLC_8699 173.55098000000004 145.958 102.46787027137817 110.40652 84.8469 86.26300275400224 320.8732 280.185 165.54237716276762 122.514;339.498;69.5519;190.233;145.958 84.8469;260.156;41.1016;69.2223;96.7058 216.573;486.944;124.212;496.452;280.185 3 293656;84029;24404 RGD1307603_9684;HAO2_8778;GPX1_33050 60.291940000000004 32.0155 70.79590393526168 36.20357 12.3892 49.87499628154072 128.90883333333332 78.5761 136.02319285196677 32.0155;140.856;8.00432 12.3892;93.5219;2.69961 78.5761;282.925;25.2254 0 Exp 4,2(0.25);Hill,2(0.25);Linear,1(0.13);Poly 2,3(0.38) 2.0790396878248587 18.219900012016296 1.567038655281067 5.5128583908081055 1.3166302339922524 1.798611342906952 58.83817340440959 203.31950659559038 26.98004848875972 138.18077901124025 127.23902650539823 370.5340984946018 UP 0.625 0.375 0.0 GO:0021782 5 glial cell development 22 22 3 3 3 3 3 3 66 19 2459 0.9975 0.020267 0.020267 13.64 94195;58835;24426 s100a9;phgdh;gstp1 S100A9_9775;PHGDH_9470;GSTP1_8762 402.88599999999997 122.826 122.514 485.34837416437273 293.4051557577879 414.0916173934969 318.22256666666664 84.8469 67.6778 419.17530204777495 219.49196874343718 360.23036415964725 540.5696666666666 246.456 216.573 535.5077371545003 426.9294641232062 452.5025824258451 0.5 122.66999999999999 1.5 543.072 963.318;122.826;122.514 802.143;67.6778;84.8469 1158.68;246.456;216.573 3 0 3 94195;58835;24426 S100A9_9775;PHGDH_9470;GSTP1_8762 402.88599999999997 122.826 485.34837416437273 318.22256666666664 84.8469 419.17530204777495 540.5696666666666 246.456 535.5077371545003 963.318;122.826;122.514 802.143;67.6778;84.8469 1158.68;246.456;216.573 0 0 Exp 4,1(0.34);Poly 2,2(0.67) 2.5664790783383786 9.016330361366272 1.7056305408477783 5.5128583908081055 2.171974438568975 1.7978414297103882 -146.33738837011379 952.1093883701137 -156.11894134418742 792.5640746775208 -65.41438428391848 1146.5537176172518 UP 1.0 0.0 0.0 GO:1901605 7 alpha-amino acid metabolic process 67 72 9 9 9 9 9 9 60 63 2415 0.99998 1.0102E-4 1.0102E-4 12.5 287877;293820;58835;116682;29739;25283;81508;25612;296925 pycr1;psat1;phgdh;kynu;gclm;gclc;bhmt;asns;aass PYCR1_9631;PSAT1_9583;PHGDH_9470;KYNU_8979;GCLM_8700;GCLC_8699;BHMT_8143;ASNS_8091;AASS_7936 81.84781555555554 100.381 5.5396 71.41673232720733 86.83238431615491 71.74398900364801 45.99838888888889 67.6778 1.97501 40.69078915244685 50.262753296883766 41.483691765873786 177.16991111111113 161.456 14.0792 157.88891701730876 181.26955847036564 158.63372818038937 2.5 16.60699 6.5 139.313 132.668;27.1579;122.826;100.381;190.233;145.958;5.5396;6.05608;5.81076 90.3184;10.0144;67.6778;72.7231;69.2223;96.7058;1.97501;2.7438;2.60489 239.858;103.876;246.456;161.456;496.452;280.185;37.8319;14.3351;14.0792 6 3 6 287877;293820;58835;29739;25283;25612 PYCR1_9631;PSAT1_9583;PHGDH_9470;GCLM_8700;GCLC_8699;ASNS_8091 104.14983 127.747 71.93116383905243 56.11375 68.45005 40.241112245451156 230.19368333333333 243.15699999999998 165.10697745256454 132.668;27.1579;122.826;190.233;145.958;6.05608 90.3184;10.0144;67.6778;69.2223;96.7058;2.7438 239.858;103.876;246.456;496.452;280.185;14.3351 3 116682;81508;296925 KYNU_8979;BHMT_8143;AASS_7936 37.243786666666665 5.81076 54.678598761860506 25.767666666666667 2.60489 40.66581767091907 71.12236666666666 37.8319 79.12756582078923 100.381;5.5396;5.81076 72.7231;1.97501;2.60489 161.456;37.8319;14.0792 0 Exp 4,2(0.23);Hill,4(0.45);Poly 2,3(0.34) 2.0662585138768472 19.113775730133057 1.6724973917007446 3.5324413776397705 0.5853467904546928 1.90879225730896 35.18888376844678 128.50674734266434 19.413739975956947 72.58303780182084 74.01581865980273 280.3240035624195 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0015914 7 phospholipid transport 20 20 3 3 3 2 2 2 67 18 2460 0.98441 0.1005 0.1005 10.0 24207;301111 apoc3;ano10 APOC3_32553;ANO10_8049 6.397605 6.397605 2.87451 4.98240873052884 5.107207252815588 4.636177743160069 2.026935 2.026935 1.13737 1.258034887612423 1.7011156076832723 1.1706131836053768 20.713355 20.713355 8.23841 17.64223640885843 16.14417905548262 16.416265345142833 0.0 2.87451 1.0 9.9207 2.87451;9.9207 1.13737;2.9165 8.23841;33.1883 1 1 1 301111 ANO10_8049 9.9207 9.9207 2.9165 2.9165 33.1883 33.1883 9.9207 2.9165 33.1883 1 24207 APOC3_32553 2.87451 2.87451 1.13737 1.13737 8.23841 8.23841 2.87451 1.13737 8.23841 0 Exp 4,1(0.5);Hill,1(0.5) 1.5491651037938188 3.0987610816955566 1.5235437154769897 1.575217366218567 0.03653878884803447 1.5493805408477783 -0.5076611999999994 13.3028712 0.2833876000000002 3.7704823999999997 -3.737537199999995 45.16424719999999 CONFLICT 0.5 0.5 0.0 GO:2000661 8 positive regulation of interleukin-1-mediated signaling pathway 1 1 1 1 1 1 1 1 68 0 2478 1.0 0.027091 0.027091 100.0 25663 il1r1 IL1R1_8893 76.6218 76.6218 76.6218 76.6218 27.5215 27.5215 27.5215 27.5215 185.143 185.143 185.143 185.143 0.0 76.6218 0.0 76.6218 76.6218 27.5215 185.143 1 0 1 25663 IL1R1_8893 76.6218 76.6218 27.5215 27.5215 185.143 185.143 76.6218 27.5215 185.143 0 0 Hill,1(1) 1.6931662559509277 1.6931662559509277 1.6931662559509277 1.6931662559509277 0.0 1.6931662559509277 76.6218 76.6218 27.5215 27.5215 185.143 185.143 UP 1.0 0.0 0.0 GO:0009653 3 anatomical structure morphogenesis 282 299 10 10 10 6 6 6 63 293 2185 0.28224 0.83822 0.56881 2.01 83472;308843;64194;29200;24890;25426 ugdh;tsku;insig1;inhba;esr1;cyp1b1 UGDH_10131;TSKU_10094;INSIG1_8906;INHBA_33300;ESR1_33192;CYP1B1_32710 87.16416666666667 75.5883 12.5403 76.2191818491557 104.40377165652389 92.31468235871385 53.50606833333333 34.80055 3.74981 66.87796236894195 70.99746117695017 81.720170577051 159.92146666666667 160.4835 51.2968 85.67777253796146 174.10275750516846 100.69918671786415 59.3662;92.2997;37.6554;91.8104;12.5403;229.313 25.4417;49.0864;13.2791;44.1594;3.74981;185.32 135.068;185.899;101.065;186.93;51.2968;299.27 4 2 4 83472;308843;64194;25426 UGDH_10131;TSKU_10094;INSIG1_8906;CYP1B1_32710 104.658575 75.83295 86.08579471776493 68.2818 37.26405 79.42916092489793 180.3255 160.4835 86.6204867010878 59.3662;92.2997;37.6554;229.313 25.4417;49.0864;13.2791;185.32 135.068;185.899;101.065;299.27 2 29200;24890 INHBA_33300;ESR1_33192 52.17535 52.17535 56.052425255335734 23.954605 23.954605 28.573895113968096 119.1134 119.1134 95.90715547403126 91.8104;12.5403 44.1594;3.74981 186.93;51.2968 0 Exp 4,1(0.17);Exp 5,1(0.17);Hill,3(0.5);Linear,1(0.17) 2.2520404306096125 14.083080053329468 1.5737498998641968 3.334043025970459 0.7482678641720782 2.129513442516327 26.176119313341317 148.15221401999202 -0.00744672804781743 107.01958339471449 91.36497049469268 228.47796283864068 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0071407 6 cellular response to organic cyclic compound 197 209 24 24 18 18 12 12 57 197 2281 0.99675 0.0090083 0.011508 5.74 361042;24614;59107;64194;29200;24426;29739;25283;24890;25315;25426;24296 pck2;orm1;ltbp1;insig1;inhba;gstp1;gclm;gclc;esr1;ephx1;cyp1b1;cyp1a1 PCK2_9440;ORM1_9400;LTBP1_33264;INSIG1_8906;INHBA_33300;GSTP1_8762;GCLM_8700;GCLC_8699;ESR1_33192;EPHX1_8567;CYP1B1_32710;CYP1A1_8415 198.26631916666665 107.1622 6.67763 252.61123466777863 123.74253594338552 169.00653109615038 120.40788833333333 66.1247 1.48195 155.75634744349878 78.31952785766963 109.78517982372277 456.35050833333327 201.75150000000002 37.9425 668.5609293239833 253.45501039255728 414.7932739980869 9.5 445.9015 6.67763;662.49;769.394;37.6554;91.8104;122.514;190.233;145.958;12.5403;27.5708;229.313;83.0393 1.48195;432.445;438.027;13.2791;44.1594;84.8469;69.2223;96.7058;3.74981;12.6303;185.32;63.0271 37.9425;1413.32;2211.2;101.065;186.93;216.573;496.452;280.185;51.2968;61.9858;299.27;119.986 9 3 9 361042;24614;64194;24426;29739;25283;25315;25426;24296 PCK2_9440;ORM1_9400;INSIG1_8906;GSTP1_8762;GCLM_8700;GCLC_8699;EPHX1_8567;CYP1B1_32710;CYP1A1_8415 167.27234777777778 122.514 200.3987629661478 106.55093888888888 69.2223 134.54899791419803 336.30881111111114 216.573 428.787263892039 6.67763;662.49;37.6554;122.514;190.233;145.958;27.5708;229.313;83.0393 1.48195;432.445;13.2791;84.8469;69.2223;96.7058;12.6303;185.32;63.0271 37.9425;1413.32;101.065;216.573;496.452;280.185;61.9858;299.27;119.986 3 59107;29200;24890 LTBP1_33264;INHBA_33300;ESR1_33192 291.2482333333333 91.8104 415.9789271398773 161.97873666666666 44.1594 239.91710340866496 816.4755999999999 186.93 1209.7690710222676 769.394;91.8104;12.5403 438.027;44.1594;3.74981 2211.2;186.93;51.2968 0 Exp 2,1(0.09);Exp 5,1(0.09);Hill,5(0.42);Linear,2(0.17);Poly 2,3(0.25) 2.374433905035634 32.332438826560974 1.5140434503555298 6.292444229125977 1.60844985175042 1.9376640915870667 55.33805811761627 341.194580215717 32.280438591326345 208.5353380753403 78.0765524687626 834.624464197904 UP 0.75 0.25 0.0 GO:0042574 8 retinal metabolic process 1 1 1 1 1 1 1 1 68 0 2478 1.0 0.027091 0.027091 100.0 25426 cyp1b1 CYP1B1_32710 229.313 229.313 229.313 229.313 185.32 185.32 185.32 185.32 299.27 299.27 299.27 299.27 0.0 229.313 0.0 229.313 229.313 185.32 299.27 1 0 1 25426 CYP1B1_32710 229.313 229.313 185.32 185.32 299.27 299.27 229.313 185.32 299.27 0 0 Linear,1(1) 3.1843981742858882 3.1843981742858887 3.1843981742858887 3.1843981742858887 0.0 3.1843981742858887 229.313 229.313 185.32 185.32 299.27 299.27 UP 1.0 0.0 0.0 GO:0006915 5 apoptotic process 137 149 5 5 4 4 3 3 66 146 2332 0.41762 0.77993 0.79601 2.01 94195;312538;24404 s100a9;mcm2;gpx1 S100A9_9775;MCM2_9206;GPX1_33050 325.0303166666667 8.00432 3.76863 552.7774057328313 145.9013447111111 413.7998099312052 268.59960433333333 2.69961 0.956203 462.0629569243025 118.7327539785325 345.95764776745307 402.2757 25.2254 22.9217 655.0663520226711 189.7970590691824 490.47009696697955 963.318;3.76863;8.00432 802.143;0.956203;2.69961 1158.68;22.9217;25.2254 2 1 2 94195;312538 S100A9_9775;MCM2_9206 483.543315 483.543315 678.5038664102794 401.5496015 401.5496015 566.5246171558299 590.8008500000001 590.8008500000001 803.1023957189051 963.318;3.76863 802.143;0.956203 1158.68;22.9217 1 24404 GPX1_33050 8.00432 8.00432 2.69961 2.69961 25.2254 25.2254 8.00432 2.69961 25.2254 0 Hill,2(0.67);Poly 2,1(0.34) 1.669260241509307 5.018316626548767 1.5280487537384033 1.7846373319625854 0.13141224107766455 1.7056305408477783 -300.49620397684794 950.5568373101812 -254.27385388975574 791.4730625564224 -339.00165996761655 1143.5530599676167 UP 0.6666666666666666 0.3333333333333333 0.0 GO:1902532 7 negative regulation of intracellular signal transduction 138 146 10 10 7 6 3 3 66 143 2335 0.43417 0.76783 0.79597 2.05 24426;24404;24890 gstp1;gpx1;esr1 GSTP1_8762;GPX1_33050;ESR1_33192 47.68620666666666 12.5403 8.00432 64.84244574344905 21.38353136918605 40.98671290222578 30.43210666666667 3.74981 2.69961 47.12751882013347 11.267783646075584 29.76507667749041 97.69839999999999 51.2968 25.2254 103.7704551804607 56.223394534883724 66.59891861370897 122.514;8.00432;12.5403 84.8469;2.69961;3.74981 216.573;25.2254;51.2968 1 2 1 24426 GSTP1_8762 122.514 122.514 84.8469 84.8469 216.573 216.573 122.514 84.8469 216.573 2 24404;24890 GPX1_33050;ESR1_33192 10.272310000000001 10.272310000000001 3.20742221732655 3.22471 3.22471 0.7426035416021101 38.2611 38.2611 18.435263735026957 8.00432;12.5403 2.69961;3.74981 25.2254;51.2968 0 Hill,2(0.67);Poly 2,1(0.34) 2.5732384782702544 9.02935779094696 1.7318620681762695 5.5128583908081055 2.167884940206406 1.7846373319625854 -25.6899282029256 121.06234153625893 -22.897701260338017 83.76191459367135 -19.728924455443178 215.1257244554432 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0008202 5 steroid metabolic process 95 104 21 20 16 10 6 6 63 98 2380 0.97924 0.060005 0.060005 5.77 299270;64194;24890;25426;24296;24207 serpina6;insig1;esr1;cyp1b1;cyp1a1;apoc3 SERPINA6_32325;INSIG1_8906;ESR1_33192;CYP1B1_32710;CYP1A1_8415;APOC3_32553 65.19950166666666 31.71495 2.87451 85.11392734357884 75.04860034575253 92.33977242567721 45.78118333333333 10.72641 1.13737 72.10952243776093 55.11115768407044 77.66980769981187 113.855035 102.1695 8.23841 99.75995741524827 120.74366562476239 110.03265561327284 4.5 156.17615 25.7745;37.6554;12.5403;229.313;83.0393;2.87451 8.17372;13.2791;3.74981;185.32;63.0271;1.13737 103.274;101.065;51.2968;299.27;119.986;8.23841 3 3 3 64194;25426;24296 INSIG1_8906;CYP1B1_32710;CYP1A1_8415 116.66923333333334 83.0393 100.15681814755965 87.20873333333333 63.0271 88.5329394135501 173.4403333333333 119.986 109.38157898080163 37.6554;229.313;83.0393 13.2791;185.32;63.0271 101.065;299.27;119.986 3 299270;24890;24207 SERPINA6_32325;ESR1_33192;APOC3_32553 13.72977 12.5403 11.496239152901266 4.353633333333334 3.74981 3.556825451724237 54.26973666666667 51.2968 47.58749421833464 25.7745;12.5403;2.87451 8.17372;3.74981;1.13737 103.274;51.2968;8.23841 0 Exp 4,1(0.17);Exp 5,1(0.17);Hill,2(0.34);Linear,1(0.17);Poly 2,1(0.17) 2.438004631177841 16.7185001373291 1.5235437154769897 6.292444229125977 1.8120478109126241 1.9931259751319885 -2.9058243853890957 133.30482771872244 -11.918451618974352 103.48081828564102 34.03044413981516 193.67962586018487 CONFLICT 0.5 0.5 0.0 GO:0001525 4 angiogenesis 67 72 3 3 3 3 3 3 66 69 2409 0.87124 0.30941 0.44395 4.17 24404;25317;25426 gpx1;fgf1;cyp1b1 GPX1_33050;FGF1_8633;CYP1B1_32710 303.82644 229.313 8.00432 339.27231424214506 320.6580974136627 322.4397738234244 208.54720333333333 185.32 2.69961 218.38955689740303 222.78844596966638 204.91827252238974 596.4984666666667 299.27 25.2254 764.5235743579483 615.4551506512057 742.65742431092 8.00432;674.162;229.313 2.69961;437.622;185.32 25.2254;1465.0;299.27 2 1 2 25317;25426 FGF1_8633;CYP1B1_32710 451.7375 451.7375 314.55574450405453 311.471 311.471 178.40445510692828 882.135 882.135 824.295588032594 674.162;229.313 437.622;185.32 1465.0;299.27 1 24404 GPX1_33050 8.00432 8.00432 2.69961 2.69961 25.2254 25.2254 8.00432 2.69961 25.2254 0 Hill,1(0.34);Linear,2(0.67) 2.074263139333843 6.539449691772461 1.5704141855239868 3.1843981742858887 0.8765620617076956 1.7846373319625854 -80.09632543432792 687.7492054343279 -38.58384481398738 455.678251480654 -268.64140058979103 1461.6383339231243 UP 0.6666666666666666 0.3333333333333333 0.0 GO:1905775 9 negative regulation of DNA helicase activity 2 2 1 1 1 1 1 1 68 1 2477 0.99928 0.053458 0.053458 50.0 312538 mcm2 MCM2_9206 3.76863 3.76863 3.76863 3.76863 0.956203 0.956203 0.956203 0.956203 22.9217 22.9217 22.9217 22.9217 0.0 3.76863 0.0 3.76863 3.76863 0.956203 22.9217 1 0 1 312538 MCM2_9206 3.76863 3.76863 0.956203 0.956203 22.9217 22.9217 3.76863 0.956203 22.9217 0 0 Hill,1(1) 1.5280487537384033 1.5280487537384033 1.5280487537384033 1.5280487537384033 0.0 1.5280487537384033 3.76863 3.76863 0.956203 0.956203 22.9217 22.9217 UP 1.0 0.0 0.0 GO:0031099 4 regeneration 111 120 10 10 9 6 5 5 64 115 2363 0.89657 0.22314 0.25732 4.17 24614;338475;24426;24404;25748 orm1;nrep;gstp1;gpx1;alas2 ORM1_9400;NREP_9364;GSTP1_8762;GPX1_33050;ALAS2_8019 221.93466399999997 125.506 8.00432 254.94376503834036 172.11623717260147 229.50259094420025 144.333642 85.7907 2.69961 166.46589027209995 110.20934508281084 150.18613995947874 467.98968 236.762 25.2254 549.2638441290414 371.5498823376316 491.41120286048175 662.49;191.159;122.514;8.00432;125.506 432.445;115.886;84.8469;2.69961;85.7907 1413.32;448.068;216.573;25.2254;236.762 2 3 2 24614;24426 ORM1_9400;GSTP1_8762 392.502 392.502 381.8206912779871 258.64594999999997 258.64594999999997 245.7889736375597 814.9465 814.9465 846.227919064657 662.49;122.514 432.445;84.8469 1413.32;216.573 3 338475;24404;25748 NREP_9364;GPX1_33050;ALAS2_8019 108.22310666666665 125.506 92.79241888728916 68.12543666666666 85.7907 58.62453297711662 236.6851333333333 236.762 211.4213104799356 191.159;8.00432;125.506 115.886;2.69961;85.7907 448.068;25.2254;236.762 0 Hill,1(0.2);Linear,1(0.2);Poly 2,3(0.6) 2.2783703500128345 12.895932912826538 1.5487829446792603 5.5128583908081055 1.6625146447322965 1.7846373319625854 -1.5333989136615855 445.4027269136616 -1.5801442607070726 290.24742826070707 -13.461306877711195 949.440666877711 DOWN 0.4 0.6 0.0 GO:0097190 5 apoptotic signaling pathway 104 107 9 9 6 7 4 4 65 103 2375 0.83846 0.32909 0.53334 3.74 170496;29200;24404;25426 lcn2;inhba;gpx1;cyp1b1 LCN2_32481;INHBA_33300;GPX1_33050;CYP1B1_32710 325.43843 160.5617 8.00432 440.99823115607575 276.6360193013461 376.8946802842044 196.02750250000003 114.7397 2.69961 249.814294171999 177.8634117090594 213.9854248963644 1148.99885 243.1 25.2254 1960.2772197064264 852.2897805681727 1688.2637252212878 972.626;91.8104;8.00432;229.313 551.931;44.1594;2.69961;185.32 4084.57;186.93;25.2254;299.27 2 2 2 170496;25426 LCN2_32481;CYP1B1_32710 600.9694999999999 600.9694999999999 525.6016628441164 368.6255 368.6255 259.23312415758147 2191.92 2191.92 2676.6112988254386 972.626;229.313 551.931;185.32 4084.57;299.27 2 29200;24404 INHBA_33300;GPX1_33050 49.90736 49.90736 59.2598474726623 23.429505 23.429505 29.316498655570207 106.07770000000001 106.07770000000001 114.34241920905819 91.8104;8.00432 44.1594;2.69961 186.93;25.2254 0 Hill,2(0.5);Linear,2(0.5) 2.217806687471553 9.118517398834229 1.7846373319625854 3.1843981742858887 0.6435351260761418 2.074740946292877 -106.73983653295426 757.6166965329542 -48.79050578855899 440.84551078855907 -772.0728253122979 3070.070525312298 CONFLICT 0.5 0.5 0.0 GO:0009066 8 aspartate family amino acid metabolic process 14 14 4 4 4 4 4 4 65 10 2468 0.99998 4.0255E-4 4.0255E-4 28.57 58835;81508;25612;296925 phgdh;bhmt;asns;aass PHGDH_9470;BHMT_8143;ASNS_8091;AASS_7936 35.05811 5.93342 5.5396 58.5123068929822 33.30812507988318 57.33360406001128 18.750375000000002 2.6743449999999998 1.97501 32.61999855471947 17.775908836110634 31.962168107230514 78.17555 26.0835 14.0792 112.73843634278712 74.77664035818589 110.52822854816907 0.0 5.5396 0.5 5.67518 122.826;5.5396;6.05608;5.81076 67.6778;1.97501;2.7438;2.60489 246.456;37.8319;14.3351;14.0792 2 2 2 58835;25612 PHGDH_9470;ASNS_8091 64.44104 64.44104 82.56880227061065 35.2108 35.2108 45.91527172956729 130.39555 130.39555 164.1342624451245 122.826;6.05608 67.6778;2.7438 246.456;14.3351 2 81508;296925 BHMT_8143;AASS_7936 5.67518 5.67518 0.1917390747865672 2.28995 2.28995 0.4453924193337818 25.95555 25.95555 16.795695241489714 5.5396;5.81076 1.97501;2.60489 37.8319;14.0792 0 Exp 4,2(0.5);Hill,2(0.5) 2.234021957955317 9.347861766815186 1.6724973917007446 3.5324413776397705 0.8488032898708922 2.071461498737335 -22.28395075512256 92.40017075512256 -13.217223583625081 50.71797358362508 -32.30811761593138 188.65921761593137 CONFLICT 0.5 0.5 0.0 GO:0090092 6 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 55 58 6 6 6 3 3 3 66 55 2423 0.92997 0.20632 0.20632 5.17 338475;59107;29200 nrep;ltbp1;inhba NREP_9364;LTBP1_33264;INHBA_33300 350.7878 191.159 91.8104 365.9110535216448 244.6152834342645 288.66132588065216 199.35746666666668 115.886 44.1594 209.78211528405689 138.976850146513 166.33618982752597 948.7326666666667 448.068 186.93 1101.0976748505707 628.1359492088299 866.8791682289469 1.5 480.2765 191.159;769.394;91.8104 115.886;438.027;44.1594 448.068;2211.2;186.93 0 3 0 3 338475;59107;29200 NREP_9364;LTBP1_33264;INHBA_33300 350.7878 191.159 365.9110535216448 199.35746666666668 115.886 209.78211528405689 948.7326666666667 448.068 1101.0976748505707 191.159;769.394;91.8104 115.886;438.027;44.1594 448.068;2211.2;186.93 0 Exp 2,1(0.34);Hill,1(0.34);Poly 2,1(0.34) 1.9959905197837673 6.097557425498962 1.5140434503555298 2.2924909591674805 0.449013719950821 2.291023015975952 -63.27953669035509 764.855136690355 -38.03334436495527 436.7482776982886 -297.2766497322673 2194.741983065601 DOWN 0.0 1.0 0.0 GO:0051179 2 localization 693 737 29 28 25 17 13 13 56 724 1754 0.037061 0.98123 0.060716 1.76 266730;59107;287167;170496;293502;64194;29200;360504;24890;24207;301111;25748;114628 slc17a3;ltbp1;hba-a1;lcn2;kif22;insig1;inhba;hba-a2;esr1;apoc3;ano10;alas2;abcg5 SLC17A3_9840;LTBP1_33264;LOC287167_9118;LCN2_32481;KIF22_8963;INSIG1_8906;INHBA_33300;HBA2_32600;ESR1_33192;APOC3_32553;ANO10_8049;ALAS2_8019;ABCG5_7947 227.87446661538462 93.3839 0.961856 323.59944566889794 188.25529797637077 283.2399298273182 137.1266346923077 68.9252 0.281971 190.00448576052509 118.08096124444933 173.96435660852316 669.0304753846153 186.93 4.47267 1195.6285545295011 497.7655814916739 991.4678767462253 93.3839;769.394;149.282;972.626;0.961856;37.6554;91.8104;131.05;12.5403;2.87451;9.9207;125.506;565.363 68.9252;438.027;97.0024;551.931;0.281971;13.2791;44.1594;88.5948;3.74981;1.13737;2.9165;85.7907;386.851 143.418;2211.2;334.152;4084.57;4.47267;101.065;186.93;254.163;51.2968;8.23841;33.1883;236.762;1047.94 5 8 5 266730;170496;293502;64194;301111 SLC17A3_9840;LCN2_32481;KIF22_8963;INSIG1_8906;ANO10_8049 222.9095712 37.6554 420.65299790830727 127.46675420000001 13.2791 238.9165988380301 873.3427939999999 101.065 1795.9661905729313 93.3839;972.626;0.961856;37.6554;9.9207 68.9252;551.931;0.281971;13.2791;2.9165 143.418;4084.57;4.47267;101.065;33.1883 8 59107;287167;29200;360504;24890;24207;25748;114628 LTBP1_33264;LOC287167_9118;INHBA_33300;HBA2_32600;ESR1_33192;APOC3_32553;ALAS2_8019;ABCG5_7947 230.97752625 128.27800000000002 279.94977954841283 143.16406 87.19275 170.77040560678213 541.33527625 245.4625 747.6809217655481 769.394;149.282;91.8104;131.05;12.5403;2.87451;125.506;565.363 438.027;97.0024;44.1594;88.5948;3.74981;1.13737;85.7907;386.851 2211.2;334.152;186.93;254.163;51.2968;8.23841;236.762;1047.94 0 Exp 2,1(0.08);Exp 4,2(0.16);Exp 5,1(0.08);Hill,3(0.24);Linear,2(0.16);Poly 2,4(0.31) 1.7773451874458488 23.290664076805115 1.504341721534729 2.2924909591674805 0.239054522496729 1.7586312294006348 51.96380412468989 403.78512910607935 33.83901966797143 240.41424971664398 19.079389450814006 1318.9815613184167 DOWN 0.38461538461538464 0.6153846153846154 0.0 GO:0080135 5 regulation of cellular response to stress 165 174 11 11 9 7 5 5 64 169 2309 0.6688 0.5143 0.80869 2.87 287877;316351;64194;24426;24404 pycr1;npas2;insig1;gstp1;gpx1 PYCR1_9631;NPAS2_9350;INSIG1_8906;GSTP1_8762;GPX1_33050 70.768624 53.0014 8.00432 54.45326986397493 72.83392518045625 60.42612217850793 41.105302 14.3825 2.69961 42.71609548175629 44.69556675902282 45.2970293776714 159.57428 215.15 25.2254 92.54181194947503 149.27937179945525 101.12668602727462 132.668;53.0014;37.6554;122.514;8.00432 90.3184;14.3825;13.2791;84.8469;2.69961 239.858;215.15;101.065;216.573;25.2254 3 2 3 287877;64194;24426 PYCR1_9631;INSIG1_8906;GSTP1_8762 97.61246666666666 122.514 52.171959053243654 62.8148 84.8469 42.98631769447112 185.83200000000002 216.573 74.32786168725687 132.668;37.6554;122.514 90.3184;13.2791;84.8469 239.858;101.065;216.573 2 316351;24404 NPAS2_9350;GPX1_33050 30.50286 30.50286 31.81774040159357 8.541055 8.541055 8.261050742856506 120.1877 120.1877 134.29697257414256 53.0014;8.00432 14.3825;2.69961 215.15;25.2254 0 Exp 5,1(0.2);Hill,2(0.4);Poly 2,2(0.4) 2.4604863199184557 13.669981479644775 1.7646474838256836 5.5128583908081055 1.5937833676583821 1.9665359258651733 23.038228498908445 118.49901950109157 3.662993453613147 78.54761054638684 78.45780534622885 240.6907546537712 UP 0.6 0.4 0.0 GO:0042572 8 retinol metabolic process 8 10 3 3 2 3 2 2 67 8 2470 0.99801 0.028287 0.028287 20.0 25426;24296 cyp1b1;cyp1a1 CYP1B1_32710;CYP1A1_8415 156.17615 156.17615 83.0393 103.43112517924666 157.53690513187487 103.41322133454288 124.17354999999999 124.17354999999999 63.0271 86.47413888096834 125.31121652013901 86.45917027697475 209.628 209.628 119.986 126.77293215824898 211.29584338581066 126.75098786550274 0.0 83.0393 0.0 83.0393 229.313;83.0393 185.32;63.0271 299.27;119.986 2 0 2 25426;24296 CYP1B1_32710;CYP1A1_8415 156.17615 156.17615 103.43112517924666 124.17354999999999 124.17354999999999 86.47413888096834 209.628 209.628 126.77293215824898 229.313;83.0393 185.32;63.0271 299.27;119.986 0 0 Linear,1(0.5);Poly 2,1(0.5) 4.476343140893527 9.476842403411865 3.1843981742858887 6.292444229125977 2.1977204416175224 4.738421201705933 12.827924000000024 299.52437599999996 4.326508000000004 244.02059199999997 33.92968000000002 385.32631999999995 UP 1.0 0.0 0.0 GO:0006417 7 regulation of translation 60 67 4 4 4 3 3 3 66 64 2414 0.89415 0.27193 0.42687 4.48 94195;298452;25426 s100a9;dph2;cyp1b1 S100A9_9775;DPH2_8490;CYP1B1_32710 642.255 734.134 229.313 375.52915730606065 464.18434483562606 347.4152664577191 483.584 463.289 185.32 308.9119107464133 336.2152557705759 246.08957638139643 1074.2666666666667 1158.68 299.27 736.4274521182198 852.1795103753789 823.2148159814528 963.318;734.134;229.313 802.143;463.289;185.32 1158.68;1764.85;299.27 2 1 2 94195;25426 S100A9_9775;CYP1B1_32710 596.3154999999999 596.3154999999999 519.0199129248319 493.7315 493.7315 436.1597260918299 728.975 728.975 607.694638819531 963.318;229.313 802.143;185.32 1158.68;299.27 1 298452 DPH2_8490 734.134 734.134 463.289 463.289 1764.85 1764.85 734.134 463.289 1764.85 0 Linear,2(0.67);Poly 2,1(0.34) 2.091519818416399 6.574538826942444 1.6845101118087769 3.1843981742858887 0.8599286778747298 1.7056305408477783 217.30375428395348 1067.2062457160464 134.01726534236622 833.1507346576338 240.9205547372609 1907.6127785960725 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0006928 3 movement of cell or subcellular component 248 268 11 11 10 5 4 4 65 264 2214 0.13261 0.94332 0.23551 1.49 94195;293502;24404;25426 s100a9;kif22;gpx1;cyp1b1 S100A9_9775;KIF22_8963;GPX1_33050;CYP1B1_32710 300.399294 118.65866 0.961856 454.48581644749316 159.76061869806665 281.82266249559297 247.61114525 94.009805 0.281971 379.71004079548675 129.70385578474819 234.74408494155378 371.91201750000005 162.24769999999998 4.47267 541.4437507991659 206.1482375682234 338.797863818468 963.318;0.961856;8.00432;229.313 802.143;0.281971;2.69961;185.32 1158.68;4.47267;25.2254;299.27 3 1 3 94195;293502;25426 S100A9_9775;KIF22_8963;CYP1B1_32710 397.8642853333333 229.313 502.83147158295117 329.2483236666667 185.32 419.85926120827355 487.4742233333333 299.27 599.6784658605058 963.318;0.961856;229.313 802.143;0.281971;185.32 1158.68;4.47267;299.27 1 24404 GPX1_33050 8.00432 8.00432 2.69961 2.69961 25.2254 25.2254 8.00432 2.69961 25.2254 0 Exp 4,1(0.25);Hill,1(0.25);Linear,1(0.25);Poly 2,1(0.25) 2.1220552609795016 8.766679406166077 1.7056305408477783 3.1843981742858887 0.6824833631195786 1.9383253455162048 -144.99680611854325 745.7953941185433 -124.50469472957695 619.7269852295769 -158.70285828318254 902.5268932831826 UP 0.75 0.25 0.0 GO:0050789 3 regulation of biological process 1644 1779 97 96 81 56 44 44 25 1735 743 0.16269 0.89266 0.28747 2.47 308843;360243;171497;192247;299270;94195;287877;363465;58835;361042;24614;338475;259241;316351;24567;24552;312538;59107;24539;287598;170496;288001;64194;29200;25663;360504;24426;116686;24404;29739;25283;84586;25317;24890;298452;24309;25426;24296;289185;310395;117517;25612;24207;114628 tsku;top2a;sgk2;sez6;serpina6;s100a9;pycr1;pir;phgdh;pck2;orm1;nrep;nr1d2;npas2;mt1;me1;mcm2;ltbp1;lpl;ska2;lcn2;kng1;insig1;inhba;il1r1;hba-a2;gstp1;gsr;gpx1;gclm;gclc;fgl2;fgf1;esr1;dph2;dbp;cyp1b1;cyp1a1;creg1;noct;c7;asns;apoc3;abcg5 TSKU_10094;TOP2A_10059;SGK2_32380;SEZ6_9819;SERPINA6_32325;S100A9_9775;PYCR1_9631;PIR_9487;PHGDH_9470;PCK2_9440;ORM1_9400;NREP_9364;NR1D2_9358;NPAS2_9350;MT1A_9255;ME1_9215;MCM2_9206;LTBP1_33264;LPL_32544;LOC691962_32591;LCN2_32481;KNG1L1_32433;INSIG1_8906;INHBA_33300;IL1R1_8893;HBA2_32600;GSTP1_8762;GSR_8755;GPX1_33050;GCLM_8700;GCLC_8699;FGL2_32918;FGF1_8633;ESR1_33192;DPH2_8490;DBP_8439;CYP1B1_32710;CYP1A1_8415;CREG1_8380;CCRN4L_8232;C7_8179;ASNS_8091;APOC3_32553;ABCG5_7947 288001(0.1788) 234.60769681818192 100.76715 4.48597E-12 307.4275809491427 194.3917142111444 268.91384684295934 145.50758354545468 52.7715 4.48597E-12 204.31349343243446 120.1135665210387 174.75498575385282 565.4224047727274 243.15699999999998 4.48599E-12 884.3633853397073 468.7482364831867 780.643473294284 92.2997;4.48597E-12;156.37;10.6392;25.7745;963.318;132.668;152.213;122.826;6.67763;662.49;191.159;9.46041;53.0014;818.334;13.1175;3.76863;769.394;900.118;2.47312;972.626;3.87556;37.6554;91.8104;76.6218;131.05;122.514;69.5519;8.00432;190.233;145.958;146.406;674.162;12.5403;734.134;66.0377;229.313;83.0393;97.6763;665.276;103.858;6.05608;2.87451;565.363 49.0864;4.48597E-12;100.616;3.96047;8.17372;802.143;90.3184;56.4566;67.6778;1.48195;432.445;115.886;2.2133;14.3825;540.216;6.20444;0.956203;438.027;487.466;0.810493;551.931;1.25511;13.2791;44.1594;27.5215;88.5948;84.8469;41.1016;2.69961;69.2223;96.7058;95.6156;437.622;3.74981;463.289;19.9899;185.32;63.0271;36.7323;433.686;32.7314;2.7438;1.13737;386.851 185.899;4.48599E-12;343.205;29.4997;103.274;1158.68;239.858;371.778;246.456;37.9425;1413.32;448.068;49.4216;215.15;988.495;28.4614;22.9217;2211.2;3428.38;10.3838;4084.57;13.8374;101.065;186.93;185.143;254.163;216.573;124.212;25.2254;496.452;280.185;325.091;1465.0;51.2968;1764.85;280.428;299.27;119.986;282.14;1425.48;293.781;14.3351;8.23841;1047.94 28 16 28 308843;360243;171497;94195;287877;363465;58835;361042;24614;259241;24552;312538;287598;170496;288001;64194;25663;24426;116686;29739;25283;25317;24309;25426;24296;289185;310395;25612 TSKU_10094;TOP2A_10059;SGK2_32380;S100A9_9775;PYCR1_9631;PIR_9487;PHGDH_9470;PCK2_9440;ORM1_9400;NR1D2_9358;ME1_9215;MCM2_9206;LOC691962_32591;LCN2_32481;KNG1L1_32433;INSIG1_8906;IL1R1_8893;GSTP1_8762;GSR_8755;GCLM_8700;GCLC_8699;FGF1_8633;DBP_8439;CYP1B1_32710;CYP1A1_8415;CREG1_8380;CCRN4L_8232;ASNS_8091 205.65278678571445 94.988 290.1450001462896 131.26407128571444 52.7715 204.10275785421464 482.0358392857144 228.21550000000002 834.5426834968235 92.2997;4.48597E-12;156.37;963.318;132.668;152.213;122.826;6.67763;662.49;9.46041;13.1175;3.76863;2.47312;972.626;3.87556;37.6554;76.6218;122.514;69.5519;190.233;145.958;674.162;66.0377;229.313;83.0393;97.6763;665.276;6.05608 49.0864;4.48597E-12;100.616;802.143;90.3184;56.4566;67.6778;1.48195;432.445;2.2133;6.20444;0.956203;0.810493;551.931;1.25511;13.2791;27.5215;84.8469;41.1016;69.2223;96.7058;437.622;19.9899;185.32;63.0271;36.7323;433.686;2.7438 185.899;4.48599E-12;343.205;1158.68;239.858;371.778;246.456;37.9425;1413.32;49.4216;28.4614;22.9217;10.3838;4084.57;13.8374;101.065;185.143;216.573;124.212;496.452;280.185;1465.0;280.428;299.27;119.986;282.14;1425.48;14.3351 16 192247;299270;338475;316351;24567;59107;24539;29200;360504;24404;84586;24890;298452;117517;24207;114628 SEZ6_9819;SERPINA6_32325;NREP_9364;NPAS2_9350;MT1A_9255;LTBP1_33264;LPL_32544;INHBA_33300;HBA2_32600;GPX1_33050;FGL2_32918;ESR1_33192;DPH2_8490;C7_8179;APOC3_32553;ABCG5_7947 285.27878937500003 117.45400000000001 339.2616295224334 170.43373 66.3771 208.90289781355804 711.348894375 273.972 976.0592145006456 10.6392;25.7745;191.159;53.0014;818.334;769.394;900.118;91.8104;131.05;8.00432;146.406;12.5403;734.134;103.858;2.87451;565.363 3.96047;8.17372;115.886;14.3825;540.216;438.027;487.466;44.1594;88.5948;2.69961;95.6156;3.74981;463.289;32.7314;1.13737;386.851 29.4997;103.274;448.068;215.15;988.495;2211.2;3428.38;186.93;254.163;25.2254;325.091;51.2968;1764.85;293.781;8.23841;1047.94 0 Exp 2,2(0.05);Exp 4,9(0.21);Exp 5,1(0.03);Hill,15(0.35);Linear,7(0.16);Poly 2,10(0.23) 2.051673436425975 96.4370903968811 1.503517508506775 6.292444229125977 0.9974490777507392 1.8052133917808533 143.76865159176197 325.4467420446019 85.13680414766515 205.8783629432442 304.1097232317915 826.7350863136628 UP 0.6363636363636364 0.36363636363636365 0.0 GO:0097176 5 epoxide metabolic process 2 2 1 1 1 1 1 1 68 1 2477 0.99928 0.053458 0.053458 50.0 25315 ephx1 EPHX1_8567 27.5708 27.5708 27.5708 27.5708 12.6303 12.6303 12.6303 12.6303 61.9858 61.9858 61.9858 61.9858 0.0 27.5708 0.0 27.5708 27.5708 12.6303 61.9858 1 0 1 25315 EPHX1_8567 27.5708 27.5708 12.6303 12.6303 61.9858 61.9858 27.5708 12.6303 61.9858 0 0 Hill,1(1) 3.0908896923065186 3.0908896923065186 3.0908896923065186 3.0908896923065186 0.0 3.0908896923065186 27.5708 27.5708 12.6303 12.6303 61.9858 61.9858 UP 1.0 0.0 0.0 GO:0060681 7 branch elongation involved in ureteric bud branching 1 1 1 1 1 1 1 1 68 0 2478 1.0 0.027091 0.027091 100.0 25317 fgf1 FGF1_8633 674.162 674.162 674.162 674.162 437.622 437.622 437.622 437.62199999999996 1465.0 1465.0 1465.0 1465.0 0.0 674.162 0.0 674.162 674.162 437.622 1465.0 1 0 1 25317 FGF1_8633 674.162 674.162 437.622 437.622 1465.0 1465.0 674.162 437.622 1465.0 0 0 Linear,1(1) 1.5704141855239868 1.5704141855239868 1.5704141855239868 1.5704141855239868 0.0 1.5704141855239868 674.162 674.162 437.622 437.622 1465.0 1465.0 UP 1.0 0.0 0.0 GO:2000544 7 regulation of endothelial cell chemotaxis to fibroblast growth factor 1 1 1 1 1 1 1 1 68 0 2478 1.0 0.027091 0.027091 100.0 25317 fgf1 FGF1_8633 674.162 674.162 674.162 674.162 437.622 437.622 437.622 437.62199999999996 1465.0 1465.0 1465.0 1465.0 0.0 674.162 0.0 674.162 674.162 437.622 1465.0 1 0 1 25317 FGF1_8633 674.162 674.162 437.622 437.622 1465.0 1465.0 674.162 437.622 1465.0 0 0 Linear,1(1) 1.5704141855239868 1.5704141855239868 1.5704141855239868 1.5704141855239868 0.0 1.5704141855239868 674.162 674.162 437.622 437.622 1465.0 1465.0 UP 1.0 0.0 0.0 GO:0005996 4 monosaccharide metabolic process 56 69 4 4 4 2 2 2 67 67 2411 0.71313 0.56428 0.71071 2.9 361042;25283 pck2;gclc PCK2_9440;GCLC_8699 76.317815 76.317815 6.67763 98.4860941131714 53.47380582833254 93.03662302339869 49.093875 49.093875 1.48195 67.33343006569064 33.475776751399096 63.60771037071959 159.06375 159.06375 37.9425 171.29131444158224 119.33245195873509 161.81335641731607 6.67763;145.958 1.48195;96.7058 37.9425;280.185 2 0 2 361042;25283 PCK2_9440;GCLC_8699 76.317815 76.317815 98.4860941131714 49.093875 49.093875 67.33343006569064 159.06375 159.06375 171.29131444158224 6.67763;145.958 1.48195;96.7058 37.9425;280.185 0 0 Hill,1(0.5);Poly 2,1(0.5) 1.6405964940101858 3.2893407344818115 1.528982162475586 1.7603585720062256 0.163607828185711 1.6446703672409058 -60.17694759999998 212.81257759999997 -44.225498 142.413248 -78.3339 396.4614 UP 1.0 0.0 0.0 GO:0070365 6 hepatocyte differentiation 9 9 2 2 2 2 2 2 67 7 2471 0.99858 0.023028 0.023028 22.22 361042;24296 pck2;cyp1a1 PCK2_9440;CYP1A1_8415 44.858464999999995 44.858464999999995 6.67763 53.995854679729355 44.371584751131216 53.99146430539714 32.254525 32.254525 1.48195 43.51899291414324 31.86211454134101 43.515454407889614 78.96425 78.96425 37.9425 58.0135152022785 78.44114253393666 58.00879815409813 0.0 6.67763 0.0 6.67763 6.67763;83.0393 1.48195;63.0271 37.9425;119.986 2 0 2 361042;24296 PCK2_9440;CYP1A1_8415 44.858464999999995 44.858464999999995 53.995854679729355 32.254525 32.254525 43.51899291414324 78.96425 78.96425 58.0135152022785 6.67763;83.0393 1.48195;63.0271 37.9425;119.986 0 0 Hill,1(0.5);Poly 2,1(0.5) 3.1017793255978185 7.8214263916015625 1.528982162475586 6.292444229125977 3.3682763292533773 3.9107131958007812 -29.9759716 119.6929016 -28.059721999999994 92.568772 -1.4383800000000093 159.36687999999998 UP 1.0 0.0 0.0 GO:0051881 5 regulation of mitochondrial membrane potential 32 32 3 3 3 3 3 3 66 29 2449 0.98999 0.053907 0.053907 9.38 287877;29739;25283 pycr1;gclm;gclc PYCR1_9631;GCLM_8700;GCLC_8699 156.28633333333332 145.958 132.668 30.140307867262038 151.48278180684713 29.413099795189968 85.41550000000001 90.3184 69.2223 14.382785348116608 86.33758874227233 13.05241221897316 338.83166666666665 280.185 239.858 137.98439709740123 318.82829430100264 132.86806909416146 0.5 139.313 132.668;190.233;145.958 90.3184;69.2223;96.7058 239.858;496.452;280.185 3 0 3 287877;29739;25283 PYCR1_9631;GCLM_8700;GCLC_8699 156.28633333333332 145.958 30.140307867262038 85.41550000000001 90.3184 14.382785348116608 338.83166666666665 280.185 137.98439709740123 132.668;190.233;145.958 90.3184;69.2223;96.7058 239.858;496.452;280.185 0 0 Hill,1(0.34);Poly 2,2(0.67) 1.8099750506250334 5.433798313140869 1.7603585720062256 1.90879225730896 0.08448734562020843 1.7646474838256836 122.17936420651444 190.39330246015226 69.13984621483374 101.69115378516628 182.687622202687 494.9757111306463 UP 1.0 0.0 0.0 GO:0046223 6 aflatoxin catabolic process 2 3 1 1 1 1 1 1 68 2 2476 0.99787 0.07912 0.07912 33.33 26760 akr7a3 AKR7A3_8015 57.1167 57.1167 57.1167 57.1167 33.0666 33.0666 33.0666 33.0666 102.949 102.949 102.949 102.94899999999998 0.0 57.1167 0.0 57.1167 57.1167 33.0666 102.949 1 0 1 26760 AKR7A3_8015 57.1167 57.1167 33.0666 33.0666 102.949 102.949 57.1167 33.0666 102.949 0 0 Hill,1(1) 5.204602241516113 5.204602241516113 5.204602241516113 5.204602241516113 0.0 5.204602241516113 57.1167 57.1167 33.0666 33.0666 102.949 102.949 UP 1.0 0.0 0.0 GO:1901377 6 organic heteropentacyclic compound catabolic process 2 3 1 1 1 1 1 1 68 2 2476 0.99787 0.07912 0.07912 33.33 26760 akr7a3 AKR7A3_8015 57.1167 57.1167 57.1167 57.1167 33.0666 33.0666 33.0666 33.0666 102.949 102.949 102.949 102.94899999999998 0.0 57.1167 0.0 57.1167 57.1167 33.0666 102.949 1 0 1 26760 AKR7A3_8015 57.1167 57.1167 33.0666 33.0666 102.949 102.949 57.1167 33.0666 102.949 0 0 Hill,1(1) 5.204602241516113 5.204602241516113 5.204602241516113 5.204602241516113 0.0 5.204602241516113 57.1167 57.1167 33.0666 33.0666 102.949 102.949 UP 1.0 0.0 0.0 GO:0044283 4 small molecule biosynthetic process 144 161 24 24 23 17 16 16 53 145 2333 1.0 3.1586E-6 3.1586E-6 9.94 83472;287877;293820;58835;361042;24539;116682;64194;84029;24426;25315;24296;81508;25612;360887;296925 ugdh;pycr1;psat1;phgdh;pck2;lpl;kynu;insig1;hao2;gstp1;ephx1;cyp1a1;bhmt;asns;coq8a;aass UGDH_10131;PYCR1_9631;PSAT1_9583;PHGDH_9470;PCK2_9440;LPL_32544;KYNU_8979;INSIG1_8906;HAO2_8778;GSTP1_8762;EPHX1_8567;CYP1A1_8415;BHMT_8143;ASNS_8091;ADCK3_7987;AASS_7936 143.956791875 71.20275 5.5396 237.40693258038164 107.09504786505124 195.31343926419913 85.38614687500001 44.2344 1.48195 134.95697887645517 64.10618987589618 110.72521652191995 389.99609375 127.52700000000002 14.0792 845.7731530103885 279.6471055778655 699.8793884580659 7.5 71.20275 59.3662;132.668;27.1579;122.826;6.67763;900.118;100.381;37.6554;140.856;122.514;27.5708;83.0393;5.5396;6.05608;525.072;5.81076 25.4417;90.3184;10.0144;67.6778;1.48195;487.466;72.7231;13.2791;93.5219;84.8469;12.6303;63.0271;1.97501;2.7438;336.426;2.60489 135.068;239.858;103.876;246.456;37.9425;3428.38;161.456;101.065;282.925;216.573;61.9858;119.986;37.8319;14.3351;1038.12;14.0792 10 6 10 83472;287877;293820;58835;361042;64194;24426;25315;24296;25612 UGDH_10131;PYCR1_9631;PSAT1_9583;PHGDH_9470;PCK2_9440;INSIG1_8906;GSTP1_8762;EPHX1_8567;CYP1A1_8415;ASNS_8091 62.55313099999999 48.5108 49.42393741396042 37.146145000000004 19.3604 35.282826759396464 127.71453999999999 111.93100000000001 82.46074983879303 59.3662;132.668;27.1579;122.826;6.67763;37.6554;122.514;27.5708;83.0393;6.05608 25.4417;90.3184;10.0144;67.6778;1.48195;13.2791;84.8469;12.6303;63.0271;2.7438 135.068;239.858;103.876;246.456;37.9425;101.065;216.573;61.9858;119.986;14.3351 6 24539;116682;84029;81508;360887;296925 LPL_32544;KYNU_8979;HAO2_8778;BHMT_8143;ADCK3_7987;AASS_7936 279.62956 120.6185 359.64929699644233 165.78615 83.1225 199.97047312575788 827.1320166666668 222.1905 1329.2360507389835 900.118;100.381;140.856;5.5396;525.072;5.81076 487.466;72.7231;93.5219;1.97501;336.426;2.60489 3428.38;161.456;282.925;37.8319;1038.12;14.0792 0 Exp 2,2(0.13);Exp 4,2(0.13);Exp 5,1(0.07);Hill,6(0.38);Poly 2,5(0.32) 2.295516548364879 40.82157611846924 1.528982162475586 6.292444229125977 1.4278732278534805 1.9620088934898376 27.627394910612978 260.286188839387 19.25722722553695 151.51506652446304 -24.432751225090442 804.4249387250903 UP 0.625 0.375 0.0 GO:0051239 4 regulation of multicellular organismal process 724 769 39 39 33 26 21 21 48 748 1730 0.57666 0.52859 1.0 2.73 192247;94195;24614;338475;259241;316351;59107;24539;170496;288001;29200;25663;24426;24404;84586;25317;24890;25426;310395;24207;114628 sez6;s100a9;orm1;nrep;nr1d2;npas2;ltbp1;lpl;lcn2;kng1;inhba;il1r1;gstp1;gpx1;fgl2;fgf1;esr1;cyp1b1;noct;apoc3;abcg5 SEZ6_9819;S100A9_9775;ORM1_9400;NREP_9364;NR1D2_9358;NPAS2_9350;LTBP1_33264;LPL_32544;LCN2_32481;KNG1L1_32433;INHBA_33300;IL1R1_8893;GSTP1_8762;GPX1_33050;FGL2_32918;FGF1_8633;ESR1_33192;CYP1B1_32710;CCRN4L_8232;APOC3_32553;ABCG5_7947 288001(0.1788) 339.56985238095245 146.406 2.87451 364.24188819517417 298.77378614187836 337.04441113057925 216.80564619047618 95.6156 1.13737 242.25874687569998 191.78092768373935 217.13922991530916 870.87211 299.27 8.23841 1152.8616317010953 740.136990373894 1055.2458458324247 10.6392;963.318;662.49;191.159;9.46041;53.0014;769.394;900.118;972.626;3.87556;91.8104;76.6218;122.514;8.00432;146.406;674.162;12.5403;229.313;665.276;2.87451;565.363 3.96047;802.143;432.445;115.886;2.2133;14.3825;438.027;487.466;551.931;1.25511;44.1594;27.5215;84.8469;2.69961;95.6156;437.622;3.74981;185.32;433.686;1.13737;386.851 29.4997;1158.68;1413.32;448.068;49.4216;215.15;2211.2;3428.38;4084.57;13.8374;186.93;185.143;216.573;25.2254;325.091;1465.0;51.2968;299.27;1425.48;8.23841;1047.94 10 11 10 94195;24614;259241;170496;288001;25663;24426;25317;25426;310395 S100A9_9775;ORM1_9400;NR1D2_9358;LCN2_32481;KNG1L1_32433;IL1R1_8893;GSTP1_8762;FGF1_8633;CYP1B1_32710;CCRN4L_8232 437.965677 445.9015 389.5000603255178 295.89838100000003 308.8825 275.1594179805692 1031.1295 728.975 1235.7202541325544 963.318;662.49;9.46041;972.626;3.87556;76.6218;122.514;674.162;229.313;665.276 802.143;432.445;2.2133;551.931;1.25511;27.5215;84.8469;437.622;185.32;433.686 1158.68;1413.32;49.4216;4084.57;13.8374;185.143;216.573;1465.0;299.27;1425.48 11 192247;338475;316351;59107;24539;29200;24404;84586;24890;24207;114628 SEZ6_9819;NREP_9364;NPAS2_9350;LTBP1_33264;LPL_32544;INHBA_33300;GPX1_33050;FGL2_32918;ESR1_33192;APOC3_32553;ABCG5_7947 250.11910272727275 91.8104 332.14713661315767 144.90316 44.1594 193.1179461635957 725.1835736363637 215.15 1111.236111828073 10.6392;191.159;53.0014;769.394;900.118;91.8104;8.00432;146.406;12.5403;2.87451;565.363 3.96047;115.886;14.3825;438.027;487.466;44.1594;2.69961;95.6156;3.74981;1.13737;386.851 29.4997;448.068;215.15;2211.2;3428.38;186.93;25.2254;325.091;51.2968;8.23841;1047.94 0 Exp 2,2(0.1);Exp 4,2(0.1);Hill,7(0.34);Linear,6(0.29);Poly 2,4(0.2) 2.019825866490306 45.255555510520935 1.5140434503555298 5.5128583908081055 0.96348794446988 1.7575112581253052 183.7810234810031 495.3586812809017 113.18986862699232 320.4214237539601 377.78504531247984 1363.9591746875199 CONFLICT 0.47619047619047616 0.5238095238095238 0.0 GO:0009991 4 response to extracellular stimulus 248 265 31 31 27 20 17 17 52 248 2230 0.99985 4.6854E-4 4.6854E-4 6.42 361042;24614;59107;24539;170496;116682;24426;116686;24404;29739;25283;25426;24296;310395;25612;24207;114628 pck2;orm1;ltbp1;lpl;lcn2;kynu;gstp1;gsr;gpx1;gclm;gclc;cyp1b1;cyp1a1;noct;asns;apoc3;abcg5 PCK2_9440;ORM1_9400;LTBP1_33264;LPL_32544;LCN2_32481;KYNU_8979;GSTP1_8762;GSR_8755;GPX1_33050;GCLM_8700;GCLC_8699;CYP1B1_32710;CYP1A1_8415;CCRN4L_8232;ASNS_8091;APOC3_32553;ABCG5_7947 323.52174941176474 145.958 2.87451 346.141524124369 261.5997427617942 310.7443736504903 197.14209 84.8469 1.13737 203.84037736139487 165.53872162602283 188.77132305622968 905.574435882353 280.185 8.23841 1250.8278030327265 667.8919472701284 1069.0149894240285 12.5 663.883 6.67763;662.49;769.394;900.118;972.626;100.381;122.514;69.5519;8.00432;190.233;145.958;229.313;83.0393;665.276;6.05608;2.87451;565.363 1.48195;432.445;438.027;487.466;551.931;72.7231;84.8469;41.1016;2.69961;69.2223;96.7058;185.32;63.0271;433.686;2.7438;1.13737;386.851 37.9425;1413.32;2211.2;3428.38;4084.57;161.456;216.573;124.212;25.2254;496.452;280.185;299.27;119.986;1425.48;14.3351;8.23841;1047.94 11 6 11 361042;24614;170496;24426;116686;29739;25283;25426;24296;310395;25612 PCK2_9440;ORM1_9400;LCN2_32481;GSTP1_8762;GSR_8755;GCLM_8700;GCLC_8699;CYP1B1_32710;CYP1A1_8415;CCRN4L_8232;ASNS_8091 286.70317363636366 145.958 325.60734141764857 178.4101318181818 84.8469 197.72350537418697 773.8477818181818 280.185 1209.08392857246 6.67763;662.49;972.626;122.514;69.5519;190.233;145.958;229.313;83.0393;665.276;6.05608 1.48195;432.445;551.931;84.8469;41.1016;69.2223;96.7058;185.32;63.0271;433.686;2.7438 37.9425;1413.32;4084.57;216.573;124.212;496.452;280.185;299.27;119.986;1425.48;14.3351 6 59107;24539;116682;24404;24207;114628 LTBP1_33264;LPL_32544;KYNU_8979;GPX1_33050;APOC3_32553;ABCG5_7947 391.02247166666666 332.872 403.6265848396381 231.4840133333333 229.78705 229.31750491004306 1147.0733016666666 604.698 1405.2389393808928 769.394;900.118;100.381;8.00432;2.87451;565.363 438.027;487.466;72.7231;2.69961;1.13737;386.851 2211.2;3428.38;161.456;25.2254;8.23841;1047.94 0 Exp 2,2(0.12);Exp 4,2(0.12);Hill,4(0.24);Linear,5(0.3);Poly 2,4(0.24) 2.1504422683244924 40.96308481693268 1.5140434503555298 6.292444229125977 1.4343113517742538 1.7846373319625854 158.9765136388804 488.06698518464884 100.24252547126378 294.0416545287363 310.9686419604765 1500.1802298042294 UP 0.6470588235294118 0.35294117647058826 0.0 GO:0042398 6 cellular modified amino acid biosynthetic process 19 20 3 3 3 3 3 3 66 17 2461 0.99828 0.015593 0.015593 15.0 84029;29739;25283 hao2;gclm;gclc HAO2_8778;GCLM_8700;GCLC_8699 159.01566666666665 145.958 140.856 27.15509208847099 160.46630987992415 27.514366163430683 86.48333333333333 93.5219 69.2223 15.033022271098226 85.86380928305597 15.397753557314674 353.1873333333333 282.925 280.185 124.07840439147095 359.0494917491749 126.49331989170894 0.0 140.856 1.0 145.958 140.856;190.233;145.958 93.5219;69.2223;96.7058 282.925;496.452;280.185 2 1 2 29739;25283 GCLM_8700;GCLC_8699 168.09550000000002 168.09550000000002 31.30715273703435 82.96405 82.96405 19.433769220740455 388.3185 388.3185 152.9238622468713 190.233;145.958 69.2223;96.7058 496.452;280.185 1 84029 HAO2_8778 140.856 140.856 93.5219 93.5219 282.925 282.925 140.856 93.5219 282.925 0 Hill,1(0.34);Poly 2,2(0.67) 1.9243743832704572 5.7899956703186035 1.7603585720062256 2.120844841003418 0.18117634472136185 1.90879225730896 128.28678720145712 189.74454613187623 69.4718672016271 103.49479946503956 212.779400988305 493.59526567836156 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0048512 4 circadian behavior 13 13 4 4 3 3 2 2 67 11 2467 0.99552 0.046539 0.046539 15.38 259241;316351 nr1d2;npas2 NR1D2_9358;NPAS2_9350 31.230905 31.230905 9.46041 30.78812928857565 15.047390078853045 20.593605674676734 8.2979 8.2979 2.2133 8.604923841615333 3.7747959139784943 5.755673129533254 132.2858 132.2858 49.4216 117.18767547519664 70.68710795698924 78.38465130662154 0.0 9.46041 0.5 31.230905 9.46041;53.0014 2.2133;14.3825 49.4216;215.15 1 1 1 259241 NR1D2_9358 9.46041 9.46041 2.2133 2.2133 49.4216 49.4216 9.46041 2.2133 49.4216 1 316351 NPAS2_9350 53.0014 53.0014 14.3825 14.3825 215.15 215.15 53.0014 14.3825 215.15 0 Hill,2(1) 2.397942173190809 4.8183066844940186 2.177004337310791 2.6413023471832275 0.32830827127221845 2.4091533422470093 -11.439265199999998 73.9010752 -3.6279159999999973 20.223715999999996 -30.12803200000002 294.699632 CONFLICT 0.5 0.5 0.0 GO:0042541 6 hemoglobin biosynthetic process 5 5 2 2 2 2 2 2 67 3 2475 0.99982 0.0068619 0.0068619 40.0 29200;25748 inhba;alas2 INHBA_33300;ALAS2_8019 108.6582 108.6582 91.8104 23.826387256149417 105.71734683330993 23.4605945147162 64.97505 64.97505 44.1594 29.437774539611528 61.34159220615082 28.985833415060426 211.846 211.846 186.93 35.236545120087975 207.4968091560174 34.695578825049836 0.0 91.8104 0.0 91.8104 91.8104;125.506 44.1594;85.7907 186.93;236.762 0 2 0 2 29200;25748 INHBA_33300;ALAS2_8019 108.6582 108.6582 23.826387256149417 64.97505 64.97505 29.437774539611528 211.846 211.846 35.236545120087975 91.8104;125.506 44.1594;85.7907 186.93;236.762 0 Hill,1(0.5);Poly 2,1(0.5) 2.0078959619239605 4.051122188568115 1.7586312294006348 2.2924909591674805 0.37749583512055435 2.0255610942840576 75.636512 141.679888 24.176375999999998 105.77372399999999 163.01064000000002 260.68136 DOWN 0.0 1.0 0.0 GO:0030195 6 negative regulation of blood coagulation 26 26 1 1 1 1 1 1 68 25 2453 0.84472 0.5121 0.5121 3.85 288001 kng1 KNG1L1_32433 288001(0.1788) 3.87556 3.87556 3.87556 3.87556 1.25511 1.25511 1.25511 1.25511 13.8374 13.8374 13.8374 13.8374 3.87556 1.25511 13.8374 1 0 1 288001 KNG1L1_32433 3.87556 3.87556 1.25511 1.25511 13.8374 13.8374 3.87556 1.25511 13.8374 0 0 Exp 4,1(1) 1.5755720138549805 1.5755720138549805 1.5755720138549805 1.5755720138549805 0.0 1.5755720138549805 3.87556 3.87556 1.25511 1.25511 13.8374 13.8374 UP 1.0 0.0 0.0 GO:0000302 5 response to reactive oxygen species 109 115 10 10 9 6 6 6 63 109 2369 0.96615 0.088414 0.12788 5.22 170496;25663;360504;24426;24404;25426 lcn2;il1r1;hba-a2;gstp1;gpx1;cyp1b1 LCN2_32481;IL1R1_8893;HBA2_32600;GSTP1_8762;GPX1_33050;CYP1B1_32710 256.6881866666667 126.78200000000001 8.00432 358.15404196227445 239.29843945106717 321.8753775093422 156.81896833333334 86.72085000000001 2.69961 203.58337558320727 153.6236304180237 184.8177449869962 844.1574 235.368 25.2254 1590.2252210365425 709.2581717881424 1429.9753865207415 4.5 600.9694999999999 972.626;76.6218;131.05;122.514;8.00432;229.313 551.931;27.5215;88.5948;84.8469;2.69961;185.32 4084.57;185.143;254.163;216.573;25.2254;299.27 4 2 4 170496;25663;24426;25426 LCN2_32481;IL1R1_8893;GSTP1_8762;CYP1B1_32710 350.26869999999997 175.9135 419.80698718874766 212.40485 135.08345 235.55924898615922 1196.3890000000001 257.9215 1926.0555422325356 972.626;76.6218;122.514;229.313 551.931;27.5215;84.8469;185.32 4084.57;185.143;216.573;299.27 2 360504;24404 HBA2_32600;GPX1_33050 69.52716000000001 69.52716000000001 87.00643472370994 45.647205 45.647205 60.73707132030694 139.6942 139.6942 161.88332942857338 131.05;8.00432 88.5948;2.69961 254.163;25.2254 0 Hill,2(0.34);Linear,2(0.34);Poly 2,2(0.34) 2.4016512993307417 15.980083346366882 1.6931662559509277 5.5128583908081055 1.5010980069838387 1.9025115966796875 -29.894733026822905 543.2711063601563 -6.081659162132212 319.7195958287989 -428.2877867637468 2116.602586763747 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0006108 8 malate metabolic process 2 2 1 1 1 1 1 1 68 1 2477 0.99928 0.053458 0.053458 50.0 24552 me1 ME1_9215 13.1175 13.1175 13.1175 13.1175 6.20444 6.20444 6.20444 6.20444 28.4614 28.4614 28.4614 28.4614 0.0 13.1175 0.0 13.1175 13.1175 6.20444 28.4614 1 0 1 24552 ME1_9215 13.1175 13.1175 6.20444 6.20444 28.4614 28.4614 13.1175 6.20444 28.4614 0 0 Exp 4,1(1) 3.175331592559815 3.1753315925598145 3.1753315925598145 3.1753315925598145 0.0 3.1753315925598145 13.1175 13.1175 6.20444 6.20444 28.4614 28.4614 UP 1.0 0.0 0.0 GO:0042325 8 regulation of phosphorylation 405 429 20 20 17 7 5 5 64 424 2054 0.016232 0.99454 0.032525 1.17 29200;24426;25317;24890;24207 inhba;gstp1;fgf1;esr1;apoc3 INHBA_33300;GSTP1_8762;FGF1_8633;ESR1_33192;APOC3_32553 180.780242 91.8104 2.87451 280.48675299918233 200.53021997677783 320.03372474858134 114.30309600000001 44.1594 1.13737 183.95069301418582 127.04794076633122 209.55930175700138 385.60764200000006 186.93 8.23841 609.7755026389973 437.6004143866321 692.7899731349337 91.8104;122.514;674.162;12.5403;2.87451 44.1594;84.8469;437.622;3.74981;1.13737 186.93;216.573;1465.0;51.2968;8.23841 2 3 2 24426;25317 GSTP1_8762;FGF1_8633 398.338 398.338 390.07404162799656 261.23445000000004 261.23445000000004 249.44966544376237 840.7865 840.7865 882.7711975163779 122.514;674.162 84.8469;437.622 216.573;1465.0 3 29200;24890;24207 INHBA_33300;ESR1_33192;APOC3_32553 35.74173666666667 12.5403 48.79680450676082 16.34886 3.74981 24.120029270444512 82.15507000000001 51.2968 93.25688020048011 91.8104;12.5403;2.87451 44.1594;3.74981;1.13737 186.93;51.2968;8.23841 0 Exp 4,1(0.2);Hill,2(0.4);Linear,1(0.2);Poly 2,1(0.2) 2.2070561369858144 12.631169319152832 1.5235437154769897 5.5128583908081055 1.6973926439836033 1.7318620681762695 -65.07723702579091 426.63772102579094 -46.93679560246274 275.54298760246274 -148.88415216664094 920.099436166641 DOWN 0.4 0.6 0.0 GO:0022402 3 cell cycle process 177 191 21 20 20 6 6 6 63 185 2293 0.74325 0.41596 0.64251 3.14 360243;58835;29685;312538;293502;29200 top2a;phgdh;mcm6;mcm2;kif22;inhba TOP2A_10059;PHGDH_9470;MCM6_9210;MCM2_9206;KIF22_8963;INHBA_33300 36.873549333334076 2.82152 4.48597E-12 55.45460329570991 31.043415603229686 53.42276243691552 18.928705166667413 0.72653 4.48597E-12 29.603387117628174 16.026762609800993 28.670674469461837 78.38506166666741 16.22585 4.48599E-12 109.0452268454657 66.38779668007432 105.33050334357765 4.48597E-12;122.826;1.87441;3.76863;0.961856;91.8104 4.48597E-12;67.6778;0.496857;0.956203;0.281971;44.1594 4.48599E-12;246.456;9.53;22.9217;4.47267;186.93 5 1 5 360243;58835;29685;312538;293502 TOP2A_10059;PHGDH_9470;MCM6_9210;MCM2_9206;KIF22_8963 25.886179200000896 1.87441 54.20884627995909 13.882566200000898 0.496857 30.074478757135022 56.676074000000895 9.53 106.43766147791746 4.48597E-12;122.826;1.87441;3.76863;0.961856 4.48597E-12;67.6778;0.496857;0.956203;0.281971 4.48599E-12;246.456;9.53;22.9217;4.47267 1 29200 INHBA_33300 91.8104 91.8104 44.1594 44.1594 186.93 186.93 91.8104 44.1594 186.93 0 Exp 4,2(0.34);Hill,4(0.67) 1.8648650284344948 11.28452980518341 1.5280487537384033 2.2924909591674805 0.27030146275008193 1.8095089197158813 -7.499374774563464 81.24647344123161 -4.758937911447415 42.616348244782245 -8.869292121427407 165.63941545476223 UP 0.8333333333333334 0.16666666666666666 0.0 GO:0008283 3 cell population proliferation 139 149 10 10 8 6 4 4 65 145 2333 0.62162 0.58238 1.0 2.68 24426;24404;24890;24296 gstp1;gpx1;esr1;cyp1a1 GSTP1_8762;GPX1_33050;ESR1_33192;CYP1A1_8415 56.52448 47.7898 8.00432 55.81656398764559 46.72151847773973 45.89713737086105 38.580855 33.388455 2.69961 41.78848028298429 32.53873557234589 36.449557552170674 103.27029999999999 85.6414 25.2254 85.45791863453421 82.42720500000001 60.287589261465484 122.514;8.00432;12.5403;83.0393 84.8469;2.69961;3.74981;63.0271 216.573;25.2254;51.2968;119.986 2 2 2 24426;24296 GSTP1_8762;CYP1A1_8415 102.77664999999999 102.77664999999999 27.912828055304658 73.937 73.937 15.4289285441343 168.2795 168.2795 68.29732267446504 122.514;83.0393 84.8469;63.0271 216.573;119.986 2 24404;24890 GPX1_33050;ESR1_33192 10.272310000000001 10.272310000000001 3.20742221732655 3.22471 3.22471 0.7426035416021101 38.2611 38.2611 18.435263735026957 8.00432;12.5403 2.69961;3.74981 25.2254;51.2968 0 Hill,2(0.5);Poly 2,2(0.5) 3.2178431523694564 15.321802020072937 1.7318620681762695 6.292444229125977 2.4139410623852355 3.6487478613853455 1.8242472921073372 111.22471270789265 -2.3718556773246036 79.5335656773246 19.52153973815649 187.01906026184352 CONFLICT 0.5 0.5 0.0 GO:0019516 8 lactate oxidation 1 1 1 1 1 1 1 1 68 0 2478 1.0 0.027091 0.027091 100.0 84029 hao2 HAO2_8778 140.856 140.856 140.856 140.856 93.5219 93.5219 93.5219 93.52189999999999 282.925 282.925 282.925 282.925 0.0 140.856 0.0 140.856 140.856 93.5219 282.925 0 1 0 1 84029 HAO2_8778 140.856 140.856 93.5219 93.5219 282.925 282.925 140.856 93.5219 282.925 0 Poly 2,1(1) 2.120844841003418 2.120844841003418 2.120844841003418 2.120844841003418 0.0 2.120844841003418 140.856 140.856 93.5219 93.5219 282.925 282.925 DOWN 0.0 1.0 0.0 GO:0010629 7 negative regulation of gene expression 355 375 15 15 11 9 6 6 63 369 2109 0.098469 0.95413 0.17087 1.6 24614;259241;24426;25283;24890;310395 orm1;nr1d2;gstp1;gclc;esr1;noct ORM1_9400;NR1D2_9358;GSTP1_8762;GCLC_8699;ESR1_33192;CCRN4L_8232 269.7064516666667 134.236 9.46041 310.3533187493615 218.478218799563 307.55446754146294 175.60780166666666 90.77635000000001 2.2133 203.28974029644493 140.78081870702397 202.1701917069688 572.7127333333333 248.37900000000002 49.4216 662.1100751473238 474.6329590900328 649.4433361224189 662.49;9.46041;122.514;145.958;12.5403;665.276 432.445;2.2133;84.8469;96.7058;3.74981;433.686 1413.32;49.4216;216.573;280.185;51.2968;1425.48 5 1 5 24614;259241;24426;25283;310395 ORM1_9400;NR1D2_9358;GSTP1_8762;GCLC_8699;CCRN4L_8232 321.139682 145.958 317.1098377605394 209.9794 96.7058 206.87640597065436 676.99592 280.185 682.9530121862939 662.49;9.46041;122.514;145.958;665.276 432.445;2.2133;84.8469;96.7058;433.686 1413.32;49.4216;216.573;280.185;1425.48 1 24890 ESR1_33192 12.5403 12.5403 3.74981 3.74981 51.2968 51.2968 12.5403 3.74981 51.2968 0 Hill,2(0.34);Linear,2(0.34);Poly 2,2(0.34) 2.1529793977443963 14.488377571105957 1.5487829446792603 5.5128583908081055 1.5317456950818638 1.7589349150657654 21.37207650100879 518.0408268323246 12.942131334728685 338.27347199860463 42.91433302885548 1102.511133637811 UP 0.8333333333333334 0.16666666666666666 0.0 GO:0022602 3 ovulation cycle process 24 29 2 2 2 2 2 2 67 27 2451 0.95795 0.18446 0.18446 6.9 29200;24890 inhba;esr1 INHBA_33300;ESR1_33192 52.17535 52.17535 12.5403 56.052425255335734 43.77923311345647 54.78033241465403 23.954605 23.954605 3.74981 28.573895113968096 19.674508961552963 27.92541920522214 119.1134 119.1134 51.2968 95.90715547403126 104.74742593290615 93.73057158327359 0.5 52.17535 91.8104;12.5403 44.1594;3.74981 186.93;51.2968 0 2 0 2 29200;24890 INHBA_33300;ESR1_33192 52.17535 52.17535 56.052425255335734 23.954605 23.954605 28.573895113968096 119.1134 119.1134 95.90715547403126 91.8104;12.5403 44.1594;3.74981 186.93;51.2968 0 Hill,2(1) 1.992555678975921 4.02435302734375 1.7318620681762695 2.2924909591674805 0.396424490548979 2.012176513671875 -25.509347999999996 129.860048 -15.64679319999999 63.55600319999999 -13.807136000000028 252.03393600000004 DOWN 0.0 1.0 0.0 GO:0042632 8 cholesterol homeostasis 34 35 9 9 8 5 4 4 65 31 2447 0.99782 0.013716 0.013716 11.43 24539;64194;24207;114628 lpl;insig1;apoc3;abcg5 LPL_32544;INSIG1_8906;APOC3_32553;ABCG5_7947 376.5027275 301.5092 2.87451 433.68833371064346 314.0358518406196 387.03353405235885 222.1833675 200.06504999999999 1.13737 251.65626708519613 196.07049150051637 237.9168395504647 1146.4058525 574.5025 8.23841 1592.195984485926 809.9418005049915 1262.4668112600089 0.5 20.264955 2.5 732.7405000000001 900.118;37.6554;2.87451;565.363 487.466;13.2791;1.13737;386.851 3428.38;101.065;8.23841;1047.94 1 3 1 64194 INSIG1_8906 37.6554 37.6554 13.2791 13.2791 101.065 101.065 37.6554 13.2791 101.065 3 24539;24207;114628 LPL_32544;APOC3_32553;ABCG5_7947 489.4518366666667 565.363 453.41300006264714 291.8181233333333 386.851 256.71447139784635 1494.8528033333332 1047.94 1753.3226783023645 900.118;2.87451;565.363 487.466;1.13737;386.851 3428.38;8.23841;1047.94 0 Exp 2,1(0.25);Exp 4,1(0.25);Exp 5,1(0.25);Linear,1(0.25) 1.737031254496179 6.977312445640564 1.5235437154769897 1.9665359258651733 0.18377222528091672 1.7436164021492004 -48.51183953643056 801.5172945364305 -24.439774243492224 468.8065092434922 -413.9462122962075 2706.757917296208 DOWN 0.25 0.75 0.0 GO:0006811 5 ion transport 243 256 13 12 9 8 4 4 65 252 2226 0.16095 0.92833 0.30983 1.56 266730;170496;24207;301111 slc17a3;lcn2;apoc3;ano10 SLC17A3_9840;LCN2_32481;APOC3_32553;ANO10_8049 269.7012775 51.6523 2.87451 470.41593489553196 182.9109109215293 397.2391792415932 156.2275175 35.92085 1.13737 265.6816156241374 107.65851448354273 224.6220023625019 1067.3536775 88.30315 8.23841 2012.3348504319656 694.4464217016109 1695.8644383983478 93.3839;972.626;2.87451;9.9207 68.9252;551.931;1.13737;2.9165 143.418;4084.57;8.23841;33.1883 3 1 3 266730;170496;301111 SLC17A3_9840;LCN2_32481;ANO10_8049 358.6435333333333 93.3839 533.359520838546 207.92423333333332 68.9252 299.7411862812039 1420.3921 143.418 2307.9039318885934 93.3839;972.626;9.9207 68.9252;551.931;2.9165 143.418;4084.57;33.1883 1 24207 APOC3_32553 2.87451 2.87451 1.13737 1.13737 8.23841 8.23841 2.87451 1.13737 8.23841 0 Exp 4,1(0.25);Hill,1(0.25);Linear,1(0.25);Poly 2,1(0.25) 1.609118113912587 6.46009373664856 1.504341721534729 1.856990933418274 0.16406479835951662 1.5493805408477783 -191.30633869762124 730.7088936976213 -104.14046581165465 416.5955008116547 -904.734475923326 3039.4418309233265 UP 0.75 0.25 0.0 GO:0031100 5 animal organ regeneration 72 80 8 8 7 4 3 3 66 77 2401 0.83072 0.36969 0.47696 3.75 24614;24426;25748 orm1;gstp1;alas2 ORM1_9400;GSTP1_8762;ALAS2_8019 303.50333333333333 125.506 122.514 310.8951722837351 309.35700764759866 312.86945423990204 201.0275333333333 85.7907 84.8469 200.4139605876381 204.68158351177726 201.79278175320997 622.2183333333334 236.762 216.573 685.1885026635614 636.7671316916487 688.0680918878269 662.49;122.514;125.506 432.445;84.8469;85.7907 1413.32;216.573;236.762 2 1 2 24614;24426 ORM1_9400;GSTP1_8762 392.502 392.502 381.8206912779871 258.64594999999997 258.64594999999997 245.7889736375597 814.9465 814.9465 846.227919064657 662.49;122.514 432.445;84.8469 1413.32;216.573 1 25748 ALAS2_8019 125.506 125.506 85.7907 85.7907 236.762 236.762 125.506 85.7907 236.762 0 Linear,1(0.34);Poly 2,2(0.67) 2.467065756009331 8.820272564888 1.5487829446792603 5.5128583908081055 2.230551203352051 1.7586312294006348 -48.307673025894985 655.3143396925616 -25.76221269214517 427.8172793588118 -153.14544892521644 1397.5821155918832 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0065009 3 regulation of molecular function 643 686 34 34 25 19 11 11 58 675 1803 0.021615 0.9901 0.038675 1.6 299270;94195;312538;288001;24426;24404;29739;25317;24890;25426;24207 serpina6;s100a9;mcm2;kng1;gstp1;gpx1;gclm;fgf1;esr1;cyp1b1;apoc3 SERPINA6_32325;S100A9_9775;MCM2_9206;KNG1L1_32433;GSTP1_8762;GPX1_33050;GCLM_8700;FGF1_8633;ESR1_33192;CYP1B1_32710;APOC3_32553 288001(0.1788) 203.30707454545453 25.7745 2.87451 321.32699919514886 171.25429095422524 267.5565751688009 145.19327481818183 8.17372 0.956203 254.84909599934312 115.74197385728856 194.67598068358066 350.97897363636366 103.274 8.23841 503.12668778252964 329.6486419474993 507.65056052031474 25.7745;963.318;3.76863;3.87556;122.514;8.00432;190.233;674.162;12.5403;229.313;2.87451 8.17372;802.143;0.956203;1.25511;84.8469;2.69961;69.2223;437.622;3.74981;185.32;1.13737 103.274;1158.68;22.9217;13.8374;216.573;25.2254;496.452;1465.0;51.2968;299.27;8.23841 7 4 7 94195;312538;288001;24426;29739;25317;25426 S100A9_9775;MCM2_9206;KNG1L1_32433;GSTP1_8762;GCLM_8700;FGF1_8633;CYP1B1_32710 312.4548842857143 190.233 365.8076765554537 225.909359 84.8469 295.53281070767 524.6763 299.27 569.4171972919357 963.318;3.76863;3.87556;122.514;190.233;674.162;229.313 802.143;0.956203;1.25511;84.8469;69.2223;437.622;185.32 1158.68;22.9217;13.8374;216.573;496.452;1465.0;299.27 4 299270;24404;24890;24207 SERPINA6_32325;GPX1_33050;ESR1_33192;APOC3_32553 12.2984075 10.272310000000001 9.813470548150892 3.9401275 3.22471 3.0195948667812478 47.0086525 38.2611 41.4801933910032 25.7745;8.00432;12.5403;2.87451 8.17372;2.69961;3.74981;1.13737 103.274;25.2254;51.2968;8.23841 0 Exp 4,2(0.19);Hill,5(0.46);Linear,2(0.19);Poly 2,2(0.19) 2.000634803293527 24.04547345638275 1.5235437154769897 5.5128583908081055 1.1996117954225334 1.7318620681762695 13.414952815578602 393.19919627533045 -5.412916636229653 295.79946627259324 53.650101548879945 648.3078457238473 UP 0.6363636363636364 0.36363636363636365 0.0 GO:0048598 4 embryonic morphogenesis 73 77 3 3 3 2 2 2 67 75 2403 0.65288 0.62489 1.0 2.6 83472;64194 ugdh;insig1 UGDH_10131;INSIG1_8906 48.5108 48.5108 37.6554 15.351853904984894 46.54633715127908 15.098383680115942 19.3604 19.3604 13.2791 8.600256936859514 18.259888925150015 8.458260467038427 118.0665 118.0665 101.065 24.043751880686184 114.98979945257396 23.646772126083803 59.3662;37.6554 25.4417;13.2791 135.068;101.065 2 0 2 83472;64194 UGDH_10131;INSIG1_8906 48.5108 48.5108 15.351853904984894 19.3604 19.3604 8.600256936859514 118.0665 118.0665 24.043751880686184 59.3662;37.6554 25.4417;13.2791 135.068;101.065 0 0 Exp 5,1(0.5);Hill,1(0.5) 1.7592145168823676 3.54028582572937 1.5737498998641968 1.9665359258651733 0.2777416625406061 1.770142912864685 27.234216000000007 69.787384 7.441051999999999 31.279747999999998 84.74356 151.38944 UP 1.0 0.0 0.0 GO:0050790 4 regulation of catalytic activity 528 565 29 29 23 15 10 10 59 555 1923 0.074399 0.96152 0.1415 1.77 299270;94195;312538;288001;24426;24404;29739;25317;24890;24207 serpina6;s100a9;mcm2;kng1;gstp1;gpx1;gclm;fgf1;esr1;apoc3 SERPINA6_32325;S100A9_9775;MCM2_9206;KNG1L1_32433;GSTP1_8762;GPX1_33050;GCLM_8700;FGF1_8633;ESR1_33192;APOC3_32553 288001(0.1788) 200.706482 19.1574 2.87451 338.58635286912977 160.29334175319258 291.7540531630612 141.1806023 5.961765 0.956203 268.2679936671175 102.60628374993367 210.4792940573898 356.14987099999996 77.2854 8.23841 530.0339024628742 335.38384957880174 556.0814929965758 25.7745;963.318;3.76863;3.87556;122.514;8.00432;190.233;674.162;12.5403;2.87451 8.17372;802.143;0.956203;1.25511;84.8469;2.69961;69.2223;437.622;3.74981;1.13737 103.274;1158.68;22.9217;13.8374;216.573;25.2254;496.452;1465.0;51.2968;8.23841 6 4 6 94195;312538;288001;24426;29739;25317 S100A9_9775;MCM2_9206;KNG1L1_32433;GSTP1_8762;GCLM_8700;FGF1_8633 326.311865 156.3735 398.7046197253604 232.67425216666666 77.03460000000001 323.1457177458132 562.2440166666667 356.5125 614.1888418618248 963.318;3.76863;3.87556;122.514;190.233;674.162 802.143;0.956203;1.25511;84.8469;69.2223;437.622 1158.68;22.9217;13.8374;216.573;496.452;1465.0 4 299270;24404;24890;24207 SERPINA6_32325;GPX1_33050;ESR1_33192;APOC3_32553 12.2984075 10.272310000000001 9.813470548150892 3.9401275 3.22471 3.0195948667812478 47.0086525 38.2611 41.4801933910032 25.7745;8.00432;12.5403;2.87451 8.17372;2.69961;3.74981;1.13737 103.274;25.2254;51.2968;8.23841 0 Exp 4,2(0.2);Hill,5(0.5);Linear,1(0.1);Poly 2,2(0.2) 1.9097735093591863 20.861075282096863 1.5235437154769897 5.5128583908081055 1.2153692008216148 1.718746304512024 -9.151513704323662 410.5644777043236 -25.093622829096688 307.45482742909667 27.631454697518336 684.6682873024815 UP 0.6 0.4 0.0 GO:1901575 4 organic substance catabolic process 296 332 19 19 17 13 11 11 58 321 2157 0.82055 0.28253 0.4673 3.31 361042;24539;116682;171142;25426;24296;310395;81508;24207;26760;296925 pck2;lpl;kynu;ehhadh;cyp1b1;cyp1a1;noct;bhmt;apoc3;akr7a3;aass PCK2_9440;LPL_32544;KYNU_8979;EHHADH_8534;CYP1B1_32710;CYP1A1_8415;CCRN4L_8232;BHMT_8143;APOC3_32553;AKR7A3_8015;AASS_7936 202.09504545454544 83.0393 2.87451 300.7206860983215 160.1522598296785 251.17669996020308 126.1589109090909 63.0271 1.13737 175.04904440723587 104.57492910204333 152.22866165633232 547.2973645454546 119.986 8.23841 1038.3943694478714 384.66911720620476 797.4270658120384 6.67763;900.118;100.381;166.899;229.313;83.0393;665.276;5.5396;2.87451;57.1167;5.81076 1.48195;487.466;72.7231;105.26;185.32;63.0271;433.686;1.97501;1.13737;33.0666;2.60489 37.9425;3428.38;161.456;384.658;299.27;119.986;1425.48;37.8319;8.23841;102.949;14.0792 5 6 5 361042;25426;24296;310395;26760 PCK2_9440;CYP1B1_32710;CYP1A1_8415;CCRN4L_8232;AKR7A3_8015 208.284526 83.0393 268.5455374771537 143.31633 63.0271 176.63324171742698 397.1255 119.986 582.9766761312154 6.67763;229.313;83.0393;665.276;57.1167 1.48195;185.32;63.0271;433.686;33.0666 37.9425;299.27;119.986;1425.48;102.949 6 24539;116682;171142;81508;24207;296925 LPL_32544;KYNU_8979;EHHADH_8534;BHMT_8143;APOC3_32553;AASS_7936 196.93714500000002 53.09588 350.8593210131866 111.86106166666667 37.663995 189.16977298362244 672.4405849999999 99.64394999999999 1357.678794641702 900.118;100.381;166.899;5.5396;2.87451;5.81076 487.466;72.7231;105.26;1.97501;1.13737;2.60489 3428.38;161.456;384.658;37.8319;8.23841;14.0792 0 Exp 2,1(0.1);Exp 4,2(0.19);Hill,3(0.28);Linear,2(0.19);Poly 2,3(0.28) 2.273773308442409 28.67412304878235 1.5039241313934326 6.292444229125977 1.646743208818682 1.7575112581253052 24.380476575154603 379.80961433393634 22.711536326385357 229.60628549179646 -66.35449322159081 1160.9492223124998 CONFLICT 0.45454545454545453 0.5454545454545454 0.0 GO:0007626 3 locomotory behavior 41 43 3 3 3 2 2 2 67 41 2437 0.89103 0.32589 0.32589 4.65 192247;316351 sez6;npas2 SEZ6_9819;NPAS2_9350 31.8203 31.8203 10.6392 29.954598885980758 21.35888022618837 26.046024400130747 9.171485 9.171485 3.96047 7.369488086729634 6.597746366849266 6.407893066906217 122.32485 122.32485 29.4997 131.2745860593169 76.47818199328502 114.14544673533464 10.6392;53.0014 3.96047;14.3825 29.4997;215.15 0 2 0 2 192247;316351 SEZ6_9819;NPAS2_9350 31.8203 31.8203 29.954598885980758 9.171485 9.171485 7.369488086729634 122.32485 122.32485 131.2745860593169 10.6392;53.0014 3.96047;14.3825 29.4997;215.15 0 Hill,2(1) 3.1462528477233747 6.389039516448975 2.6413023471832275 3.747737169265747 0.7823675656354808 3.1945197582244873 -9.694655999999995 73.33525599999999 -1.0421043999999977 19.3850744 -59.61244399999997 304.262144 DOWN 0.0 1.0 0.0 GO:0008211 5 glucocorticoid metabolic process 8 9 4 4 4 1 1 1 68 8 2470 0.97697 0.21931 0.21931 11.11 299270 serpina6 SERPINA6_32325 25.7745 25.7745 25.7745 25.7745 8.17372 8.17372 8.17372 8.17372 103.274 103.274 103.274 103.274 0.0 25.7745 0.0 25.7745 25.7745 8.17372 103.274 0 1 0 1 299270 SERPINA6_32325 25.7745 25.7745 8.17372 8.17372 103.274 103.274 25.7745 8.17372 103.274 0 Hill,1(1) 2.0197160243988037 2.0197160243988037 2.0197160243988037 2.0197160243988037 0.0 2.0197160243988037 25.7745 25.7745 8.17372 8.17372 103.274 103.274 DOWN 0.0 1.0 0.0 GO:0043170 4 macromolecule metabolic process 853 925 42 41 36 27 22 22 47 903 1575 0.26026 0.81621 0.52595 2.38 83472;360243;171497;94195;291317;313108;29685;312538;293502;29200;24404;499709;84586;24890;171142;298452;25426;310395;81508;24207;25748;360887 ugdh;top2a;sgk2;s100a9;rpp38;mms22l;mcm6;mcm2;kif22;inhba;gpx1;gar1;fgl2;esr1;ehhadh;dph2;cyp1b1;noct;bhmt;apoc3;alas2;coq8a UGDH_10131;TOP2A_10059;SGK2_32380;S100A9_9775;RPP38_9741;MMS22L_33129;MCM6_9210;MCM2_9206;KIF22_8963;INHBA_33300;GPX1_33050;GAR1_8683;FGL2_32918;ESR1_33192;EHHADH_8534;DPH2_8490;CYP1B1_32710;CCRN4L_8232;BHMT_8143;APOC3_32553;ALAS2_8019;ADCK3_7987 499709(-0.07184) 253.88615390909115 108.6582 4.48597E-12 334.38470667942966 197.6785879763948 299.54695185230577 183.96533277272746 64.97505 4.48597E-12 260.66160720490296 141.43890399550202 228.41074035384622 449.65711272727293 211.846 4.48599E-12 563.0071931630694 358.60739060144164 528.3452541776135 59.3662;4.48597E-12;156.37;963.318;916.962;4.13516;1.87441;3.76863;0.961856;91.8104;8.00432;765.364;146.406;12.5403;166.899;734.134;229.313;665.276;5.5396;2.87451;125.506;525.072 25.4417;4.48597E-12;100.616;802.143;769.912;1.24709;0.496857;0.956203;0.281971;44.1594;2.69961;587.034;95.6156;3.74981;105.26;463.289;185.32;433.686;1.97501;1.13737;85.7907;336.426 135.068;4.48599E-12;343.205;1158.68;1051.72;20.8956;9.53;22.9217;4.47267;186.93;25.2254;1362.21;325.091;51.2968;384.658;1764.85;299.27;1425.48;37.8319;8.23841;236.762;1038.12 11 11 11 83472;360243;171497;94195;313108;29685;312538;293502;499709;25426;310395 UGDH_10131;TOP2A_10059;SGK2_32380;S100A9_9775;MMS22L_33129;MCM6_9210;MCM2_9206;KIF22_8963;GAR1_8683;CYP1B1_32710;CCRN4L_8232 259.06793236363677 59.3662 360.37116473112644 194.29298372727314 25.4417 283.90061910921366 434.7029972727277 135.068 581.2214232406918 59.3662;4.48597E-12;156.37;963.318;4.13516;1.87441;3.76863;0.961856;765.364;229.313;665.276 25.4417;4.48597E-12;100.616;802.143;1.24709;0.496857;0.956203;0.281971;587.034;185.32;433.686 135.068;4.48599E-12;343.205;1158.68;20.8956;9.53;22.9217;4.47267;1362.21;299.27;1425.48 11 291317;29200;24404;84586;24890;171142;298452;81508;24207;25748;360887 RPP38_9741;INHBA_33300;GPX1_33050;FGL2_32918;ESR1_33192;EHHADH_8534;DPH2_8490;BHMT_8143;APOC3_32553;ALAS2_8019;ADCK3_7987 248.70437545454544 125.506 323.8535612543456 173.63768181818182 85.7907 248.69495357652545 464.61122818181815 236.762 572.1377368923103 916.962;91.8104;8.00432;146.406;12.5403;166.899;734.134;5.5396;2.87451;125.506;525.072 769.912;44.1594;2.69961;95.6156;3.74981;105.26;463.289;1.97501;1.13737;85.7907;336.426 1051.72;186.93;25.2254;325.091;51.2968;384.658;1764.85;37.8319;8.23841;236.762;1038.12 0 Exp 2,2(0.1);Exp 4,4(0.19);Hill,7(0.32);Linear,3(0.14);Poly 2,6(0.28) 1.7637026009886303 39.38385248184204 1.5039241313934326 3.1843981742858887 0.3619824059768566 1.6950703263282776 114.15567826435756 393.6166295538247 75.04177966304702 292.8888858824081 214.39138041164617 684.9228450428996 CONFLICT 0.5 0.5 0.0 GO:0006468 7 protein phosphorylation 190 202 8 8 6 4 2 2 67 200 2278 0.078528 0.97806 0.17011 0.99 171497;360887 sgk2;coq8a SGK2_32380;ADCK3_7987 340.721 340.721 156.37 260.7116844370424 272.0169819226625 241.92994482299565 218.521 218.521 100.616 166.74285007159983 174.58010870345984 154.73065046761508 690.6624999999999 690.6624999999999 343.205 491.37910884824976 561.1718741769424 455.98002616387237 156.37;525.072 100.616;336.426 343.205;1038.12 1 1 1 171497 SGK2_32380 156.37 156.37 100.616 100.616 343.205 343.205 156.37 100.616 343.205 1 360887 ADCK3_7987 525.072 525.072 336.426 336.426 1038.12 1038.12 525.072 336.426 1038.12 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.7363573249003317 3.486773133277893 1.5869897603988647 1.8997833728790283 0.22117848449656077 1.7433865666389465 -20.606959999999958 702.04896 -12.572799999999972 449.6148 9.645800000000008 1371.6791999999998 CONFLICT 0.5 0.5 0.0 GO:0071247 6 cellular response to chromate 2 2 1 1 1 1 1 1 68 1 2477 0.99928 0.053458 0.053458 50.0 24567 mt1 MT1A_9255 818.334 818.334 818.334 818.334 540.216 540.216 540.216 540.216 988.495 988.495 988.495 988.4950000000001 0.0 818.334 0.0 818.334 818.334 540.216 988.495 0 1 0 1 24567 MT1A_9255 818.334 818.334 540.216 540.216 988.495 988.495 818.334 540.216 988.495 0 Poly 2,1(1) 2.3371741771698 2.3371741771698 2.3371741771698 2.3371741771698 0.0 2.3371741771698 818.334 818.334 540.216 540.216 988.495 988.495 DOWN 0.0 1.0 0.0 GO:0048821 6 erythrocyte development 8 9 4 4 4 2 2 2 67 7 2471 0.99858 0.023028 0.023028 22.22 360504;25748 hba-a2;alas2 HBA2_32600;ALAS2_8019 128.27800000000002 128.27800000000002 125.506 3.9201999948980477 129.130822614841 3.7300610149478004 87.19275 87.19275 85.7907 1.9827981251247346 87.62409918727917 1.8866277222240302 245.4625 245.4625 236.762 12.304365099426745 248.1392616018846 11.70757426426728 0.0 125.506 0.0 125.506 131.05;125.506 88.5948;85.7907 254.163;236.762 0 2 0 2 360504;25748 HBA2_32600;ALAS2_8019 128.27800000000002 128.27800000000002 3.9201999948980477 87.19275 87.19275 1.9827981251247346 245.4625 245.4625 12.304365099426745 131.05;125.506 88.5948;85.7907 254.163;236.762 0 Poly 2,2(1) 1.8509106861791889 3.706663489341736 1.7586312294006348 1.948032259941101 0.1339267530588841 1.853331744670868 122.84488 133.71112000000002 84.444732 89.940768 228.40952 262.51548 DOWN 0.0 1.0 0.0 GO:0010987 7 negative regulation of high-density lipoprotein particle clearance 1 1 1 1 1 1 1 1 68 0 2478 1.0 0.027091 0.027091 100.0 24207 apoc3 APOC3_32553 2.87451 2.87451 2.87451 2.87451 1.13737 1.13737 1.13737 1.13737 8.23841 8.23841 8.23841 8.23841 0.0 2.87451 0.0 2.87451 2.87451 1.13737 8.23841 0 1 0 1 24207 APOC3_32553 2.87451 2.87451 1.13737 1.13737 8.23841 8.23841 2.87451 1.13737 8.23841 0 Exp 4,1(1) 1.5235437154769897 1.5235437154769897 1.5235437154769897 1.5235437154769897 0.0 1.5235437154769897 2.87451 2.87451 1.13737 1.13737 8.23841 8.23841 DOWN 0.0 1.0 0.0 GO:0045091 8 regulation of single stranded viral RNA replication via double stranded DNA intermediate 1 1 1 1 1 1 1 1 68 0 2478 1.0 0.027091 0.027091 100.0 360243 top2a TOP2A_10059 4.48597E-12 4.48597E-12 4.48597E-12 4.48597E-12 4.48597E-12 4.48597E-12 4.48597E-12 4.48597E-12 4.48599E-12 4.48599E-12 4.48599E-12 4.48599E-12 0.0 4.48597E-12 0.0 4.48597E-12 4.48597E-12 4.48597E-12 4.48599E-12 1 0 1 360243 TOP2A_10059 4.48597E-12 4.48597E-12 4.48597E-12 4.48597E-12 4.48599E-12 4.48599E-12 4.48597E-12 4.48597E-12 4.48599E-12 0 0 Hill,1(1) 1.75295889377594 1.75295889377594 1.75295889377594 1.75295889377594 0.0 1.75295889377594 4.48597E-12 4.48597E-12 4.48597E-12 4.48597E-12 4.48599E-12 4.48599E-12 UP 1.0 0.0 0.0 GO:0045870 8 positive regulation of single stranded viral RNA replication via double stranded DNA intermediate 1 1 1 1 1 1 1 1 68 0 2478 1.0 0.027091 0.027091 100.0 360243 top2a TOP2A_10059 4.48597E-12 4.48597E-12 4.48597E-12 4.48597E-12 4.48597E-12 4.48597E-12 4.48597E-12 4.48597E-12 4.48599E-12 4.48599E-12 4.48599E-12 4.48599E-12 0.0 4.48597E-12 0.0 4.48597E-12 4.48597E-12 4.48597E-12 4.48599E-12 1 0 1 360243 TOP2A_10059 4.48597E-12 4.48597E-12 4.48597E-12 4.48597E-12 4.48599E-12 4.48599E-12 4.48597E-12 4.48597E-12 4.48599E-12 0 0 Hill,1(1) 1.75295889377594 1.75295889377594 1.75295889377594 1.75295889377594 0.0 1.75295889377594 4.48597E-12 4.48597E-12 4.48597E-12 4.48597E-12 4.48599E-12 4.48599E-12 UP 1.0 0.0 0.0 GO:0043603 5 cellular amide metabolic process 114 134 17 17 15 14 12 12 57 122 2356 0.99996 1.8308E-4 1.8308E-4 8.96 293656;680308;116682;84029;24426;300850;116686;24404;29739;25283;25612;296925 rgd1307603;mthfd2;kynu;hao2;gstp1;gsta4;gsr;gpx1;gclm;gclc;asns;aass RGD1307603_9684;MTHFD2_9261;KYNU_8979;HAO2_8778;GSTP1_8762;GSTA4_8757;GSR_8755;GPX1_33050;GCLM_8700;GCLC_8699;ASNS_8091;AASS_7936 148.62154666666666 111.44749999999999 5.81076 177.41069921516734 127.51541225344675 154.4552335628697 96.08175833333335 70.9727 2.60489 122.75592091861999 81.8993782122498 108.56235653397711 285.9377333333333 189.0145 14.0792 346.3897491836152 242.27069322126505 293.5463391597339 5.5 111.44749999999999 32.0155;622.58;100.381;140.856;122.514;339.498;69.5519;8.00432;190.233;145.958;6.05608;5.81076 12.3892;414.266;72.7231;93.5219;84.8469;260.156;41.1016;2.69961;69.2223;96.7058;2.7438;2.60489 78.5761;1250.29;161.456;282.925;216.573;486.944;124.212;25.2254;496.452;280.185;14.3351;14.0792 7 5 7 680308;24426;300850;116686;29739;25283;25612 MTHFD2_9261;GSTP1_8762;GSTA4_8757;GSR_8755;GCLM_8700;GCLC_8699;ASNS_8091 213.77014000000003 145.958 208.30954301321196 138.4346285714286 84.8469 146.16659636043974 409.85587142857145 280.185 410.6849763339889 622.58;122.514;339.498;69.5519;190.233;145.958;6.05608 414.266;84.8469;260.156;41.1016;69.2223;96.7058;2.7438 1250.29;216.573;486.944;124.212;496.452;280.185;14.3351 5 293656;116682;84029;24404;296925 RGD1307603_9684;KYNU_8979;HAO2_8778;GPX1_33050;AASS_7936 57.413516 32.0155 60.3283206924383 36.78774 12.3892 43.115750035184945 112.45234 78.5761 111.68672691129417 32.0155;100.381;140.856;8.00432;5.81076 12.3892;72.7231;93.5219;2.69961;2.60489 78.5761;161.456;282.925;25.2254;14.0792 0 Exp 4,2(0.17);Hill,4(0.34);Linear,2(0.17);Poly 2,4(0.34) 2.1285105554653083 27.582741022109985 1.5278362035751343 5.5128583908081055 1.1430873501379268 1.8606888055801392 48.241994016650025 249.00109931668334 26.626057626087373 165.53745904057928 89.94928269635986 481.92618397030674 CONFLICT 0.5833333333333334 0.4166666666666667 0.0 GO:0017001 5 antibiotic catabolic process 20 22 5 5 5 4 4 4 65 18 2460 0.99977 0.0024968 0.0024968 18.18 361042;287167;360504;24404 pck2;hba-a1;hba-a2;gpx1 PCK2_9440;LOC287167_9118;HBA2_32600;GPX1_33050 73.7534875 69.52716000000001 6.67763 77.04883782690189 67.67377798583136 77.4748700392227 47.44469 45.647205 1.48195 52.48489886297518 43.14062214786776 52.64711875294726 162.870725 146.05275 25.2254 155.16104701922612 153.30936966245312 156.39560174549243 0.5 7.340975 1.5 69.52716000000001 6.67763;149.282;131.05;8.00432 1.48195;97.0024;88.5948;2.69961 37.9425;334.152;254.163;25.2254 1 3 1 361042 PCK2_9440 6.67763 6.67763 1.48195 1.48195 37.9425 37.9425 6.67763 1.48195 37.9425 3 287167;360504;24404 LOC287167_9118;HBA2_32600;GPX1_33050 96.11210666666666 131.05 76.84619710482842 62.76560333333333 88.5948 52.18826113964742 204.51346666666666 254.163 160.33626591340257 149.282;131.05;8.00432 97.0024;88.5948;2.69961 334.152;254.163;25.2254 0 Hill,2(0.5);Poly 2,2(0.5) 1.744758953202405 7.005036354064941 1.528982162475586 1.948032259941101 0.17253292202995776 1.7640109658241272 -1.754373570363839 149.26134857036385 -3.990510885715679 98.87989088571567 10.812898921158393 314.92855107884156 DOWN 0.25 0.75 0.0 GO:0033554 4 cellular response to stress 394 417 29 29 23 18 13 13 56 404 2074 0.77137 0.33505 0.61978 3.12 360243;287877;338475;313108;29685;312538;170496;293502;64194;116686;25317;25426;25612 top2a;pycr1;nrep;mms22l;mcm6;mcm2;lcn2;kif22;insig1;gsr;fgf1;cyp1b1;asns TOP2A_10059;PYCR1_9631;NREP_9364;MMS22L_33129;MCM6_9210;MCM2_9206;LCN2_32481;KIF22_8963;INSIG1_8906;GSR_8755;FGF1_8633;CYP1B1_32710;ASNS_8091 178.76395661538496 37.6554 4.48597E-12 302.5055627504528 168.6659682122297 274.12040419532565 110.86030930769266 13.2791 4.48597E-12 181.24045227086535 108.55273737177743 168.6675265039225 525.7075438461542 101.065 4.48599E-12 1140.6112409368627 436.5160524255628 953.1344692205757 4.48597E-12;132.668;191.159;4.13516;1.87441;3.76863;972.626;0.961856;37.6554;69.5519;674.162;229.313;6.05608 4.48597E-12;90.3184;115.886;1.24709;0.496857;0.956203;551.931;0.281971;13.2791;41.1016;437.622;185.32;2.7438 4.48599E-12;239.858;448.068;20.8956;9.53;22.9217;4084.57;4.47267;101.065;124.212;1465.0;299.27;14.3351 12 1 12 360243;287877;313108;29685;312538;170496;293502;64194;116686;25317;25426;25612 TOP2A_10059;PYCR1_9631;MMS22L_33129;MCM6_9210;MCM2_9206;LCN2_32481;KIF22_8963;INSIG1_8906;GSR_8755;FGF1_8633;CYP1B1_32710;ASNS_8091 177.73103633333372 21.85574 315.9328101392622 110.44150175000038 8.01145 189.29290821561906 532.1775058333337 61.99335 1191.0804038103897 4.48597E-12;132.668;4.13516;1.87441;3.76863;972.626;0.961856;37.6554;69.5519;674.162;229.313;6.05608 4.48597E-12;90.3184;1.24709;0.496857;0.956203;551.931;0.281971;13.2791;41.1016;437.622;185.32;2.7438 4.48599E-12;239.858;20.8956;9.53;22.9217;4084.57;4.47267;101.065;124.212;1465.0;299.27;14.3351 1 338475 NREP_9364 191.159 191.159 115.886 115.886 448.068 448.068 191.159 115.886 448.068 0 Exp 4,3(0.24);Exp 5,1(0.08);Hill,4(0.31);Linear,3(0.24);Poly 2,2(0.16) 1.996138879371592 26.8291574716568 1.5280487537384033 3.5324413776397705 0.6138821739712301 1.8211764097213745 14.32005949882344 343.20785373194644 12.336877157866354 209.38374145751897 -94.3357897349382 1145.7508774272465 UP 0.9230769230769231 0.07692307692307693 0.0 GO:0032268 6 regulation of cellular protein metabolic process 600 637 30 30 25 15 11 11 58 626 1852 0.047676 0.97613 0.090249 1.73 299270;94195;288001;29200;24426;24404;25283;25317;24890;298452;25426 serpina6;s100a9;kng1;inhba;gstp1;gpx1;gclc;fgf1;esr1;dph2;cyp1b1 SERPINA6_32325;S100A9_9775;KNG1L1_32433;INHBA_33300;GSTP1_8762;GPX1_33050;GCLC_8699;FGF1_8633;ESR1_33192;DPH2_8490;CYP1B1_32710 288001(0.1788) 273.76400727272727 122.514 3.87556 345.72277122301836 255.25744661218448 308.5293333476129 193.63312272727273 84.8469 1.25511 262.6948331498515 173.47957676375958 215.47376294011457 505.9201454545455 216.573 13.8374 636.5524540145868 511.8888048242519 653.0718109235152 25.7745;963.318;3.87556;91.8104;122.514;8.00432;145.958;674.162;12.5403;734.134;229.313 8.17372;802.143;1.25511;44.1594;84.8469;2.69961;96.7058;437.622;3.74981;463.289;185.32 103.274;1158.68;13.8374;186.93;216.573;25.2254;280.185;1465.0;51.2968;1764.85;299.27 6 5 6 94195;288001;24426;25283;25317;25426 S100A9_9775;KNG1L1_32433;GSTP1_8762;GCLC_8699;FGF1_8633;CYP1B1_32710 356.52342666666664 187.63549999999998 376.49306466108015 267.982135 141.0129 301.6474581866762 572.2575666666667 289.72749999999996 589.7547815574254 963.318;3.87556;122.514;145.958;674.162;229.313 802.143;1.25511;84.8469;96.7058;437.622;185.32 1158.68;13.8374;216.573;280.185;1465.0;299.27 5 299270;29200;24404;24890;298452 SERPINA6_32325;INHBA_33300;GPX1_33050;ESR1_33192;DPH2_8490 174.45270399999998 25.7745 314.68190405257036 104.414308 8.17372 201.34744238603597 426.31524 103.274 750.8075868173736 25.7745;91.8104;8.00432;12.5403;734.134 8.17372;44.1594;2.69961;3.74981;463.289 103.274;186.93;25.2254;51.2968;1764.85 0 Exp 4,1(0.1);Hill,4(0.37);Linear,3(0.28);Poly 2,3(0.28) 2.079469286457133 24.82244837284088 1.5704141855239868 5.5128583908081055 1.1760649992086265 1.7603585720062256 69.45490557162566 478.0731089738289 38.390396908252484 348.875848546293 129.74168429828774 882.0986066108031 CONFLICT 0.5454545454545454 0.45454545454545453 0.0 GO:0006767 5 water-soluble vitamin metabolic process 8 9 3 3 2 3 2 2 67 7 2471 0.99858 0.023028 0.023028 22.22 116682;25283 kynu;gclc KYNU_8979;GCLC_8699 123.1695 123.1695 100.381 32.227805766139305 124.16964470514297 32.19675271883101 84.71445 84.71445 72.7231 16.95832980116264 85.2407279564261 16.94198963139105 220.82049999999998 220.82049999999998 161.456 83.95408102349775 223.425897035718 83.8731872118411 0.0 100.381 0.0 100.381 100.381;145.958 72.7231;96.7058 161.456;280.185 1 1 1 25283 GCLC_8699 145.958 145.958 96.7058 96.7058 280.185 280.185 145.958 96.7058 280.185 1 116682 KYNU_8979 100.381 100.381 72.7231 72.7231 161.456 161.456 100.381 72.7231 161.456 0 Poly 2,2(1) 1.8563054634837484 3.7178404331207275 1.7603585720062256 1.957481861114502 0.13938721445825852 1.8589202165603638 78.50404 167.83496 61.211404 108.217496 104.46607999999999 337.17492 CONFLICT 0.5 0.5 0.0 GO:0007165 4 signal transduction 714 752 36 36 31 19 14 14 55 738 1740 0.054524 0.97069 0.10761 1.86 171497;259241;24567;24539;170496;64194;29200;25663;24404;25317;24890;25426;24207;114628 sgk2;nr1d2;mt1;lpl;lcn2;insig1;inhba;il1r1;gpx1;fgf1;esr1;cyp1b1;apoc3;abcg5 SGK2_32380;NR1D2_9358;MT1A_9255;LPL_32544;LCN2_32481;INSIG1_8906;INHBA_33300;IL1R1_8893;GPX1_33050;FGF1_8633;ESR1_33192;CYP1B1_32710;APOC3_32553;ABCG5_7947 325.3752242857143 124.09020000000001 2.87451 373.2312745050588 265.6506849751853 328.54710315387445 198.91300642857144 72.3877 1.13737 226.8004940110741 167.60493062048056 203.023863058998 876.0128721428572 243.1 8.23841 1307.0228216071705 681.2366932884573 1104.497879883451 156.37;9.46041;818.334;900.118;972.626;37.6554;91.8104;76.6218;8.00432;674.162;12.5403;229.313;2.87451;565.363 100.616;2.2133;540.216;487.466;551.931;13.2791;44.1594;27.5215;2.69961;437.622;3.74981;185.32;1.13737;386.851 343.205;49.4216;988.495;3428.38;4084.57;101.065;186.93;185.143;25.2254;1465.0;51.2968;299.27;8.23841;1047.94 7 7 7 171497;259241;170496;64194;25663;25317;25426 SGK2_32380;NR1D2_9358;LCN2_32481;INSIG1_8906;IL1R1_8893;FGF1_8633;CYP1B1_32710 308.0298014285714 156.37 369.84987624573034 188.35755714285713 100.616 221.0567824214619 932.524942857143 299.27 1471.7905458822675 156.37;9.46041;972.626;37.6554;76.6218;674.162;229.313 100.616;2.2133;551.931;13.2791;27.5215;437.622;185.32 343.205;49.4216;4084.57;101.065;185.143;1465.0;299.27 7 24567;24539;29200;24404;24890;24207;114628 MT1A_9255;LPL_32544;INHBA_33300;GPX1_33050;ESR1_33192;APOC3_32553;ABCG5_7947 342.72064714285716 91.8104 405.37532362439975 209.46845571428574 44.1594 249.6476121875831 819.5008014285714 186.93 1236.0081894972238 818.334;900.118;91.8104;8.00432;12.5403;2.87451;565.363 540.216;487.466;44.1594;2.69961;3.74981;1.13737;386.851 988.495;3428.38;186.93;25.2254;51.2968;8.23841;1047.94 0 Exp 2,1(0.08);Exp 4,1(0.08);Exp 5,1(0.08);Hill,5(0.36);Linear,4(0.29);Poly 2,2(0.15) 1.9279709674047076 27.505234241485596 1.5235437154769897 3.1843981742858887 0.43021781569634543 1.8208141326904297 129.86472655394752 520.885722017481 80.10764230489941 317.7183705522435 191.35244882205484 1560.6732954636593 CONFLICT 0.5 0.5 0.0 GO:0019222 4 regulation of metabolic process 1092 1179 62 62 52 37 28 28 41 1151 1327 0.20021 0.8616 0.39185 2.37 308843;360243;299270;94195;363465;58835;24614;259241;316351;24552;59107;24539;170496;288001;64194;29200;25663;24426;24404;25283;25317;24890;298452;24309;25426;289185;310395;24207 tsku;top2a;serpina6;s100a9;pir;phgdh;orm1;nr1d2;npas2;me1;ltbp1;lpl;lcn2;kng1;insig1;inhba;il1r1;gstp1;gpx1;gclc;fgf1;esr1;dph2;dbp;cyp1b1;creg1;noct;apoc3 TSKU_10094;TOP2A_10059;SERPINA6_32325;S100A9_9775;PIR_9487;PHGDH_9470;ORM1_9400;NR1D2_9358;NPAS2_9350;ME1_9215;LTBP1_33264;LPL_32544;LCN2_32481;KNG1L1_32433;INSIG1_8906;INHBA_33300;IL1R1_8893;GSTP1_8762;GPX1_33050;GCLC_8699;FGF1_8633;ESR1_33192;DPH2_8490;DBP_8439;CYP1B1_32710;CREG1_8380;CCRN4L_8232;APOC3_32553 288001(0.1788) 275.1818500000002 94.988 4.48597E-12 344.2686674609124 227.1742984311395 312.6997682974374 170.2928771428573 46.6229 4.48597E-12 228.75256672998796 139.9601680382733 200.88820777562546 717.2232860714287 231.5145 4.48599E-12 1059.4595922739074 589.5957422402947 963.6094366135135 92.2997;4.48597E-12;25.7745;963.318;152.213;122.826;662.49;9.46041;53.0014;13.1175;769.394;900.118;972.626;3.87556;37.6554;91.8104;76.6218;122.514;8.00432;145.958;674.162;12.5403;734.134;66.0377;229.313;97.6763;665.276;2.87451 49.0864;4.48597E-12;8.17372;802.143;56.4566;67.6778;432.445;2.2133;14.3825;6.20444;438.027;487.466;551.931;1.25511;13.2791;44.1594;27.5215;84.8469;2.69961;96.7058;437.622;3.74981;463.289;19.9899;185.32;36.7323;433.686;1.13737 185.899;4.48599E-12;103.274;1158.68;371.778;246.456;1413.32;49.4216;215.15;28.4614;2211.2;3428.38;4084.57;13.8374;101.065;186.93;185.143;216.573;25.2254;280.185;1465.0;51.2968;1764.85;280.428;299.27;282.14;1425.48;8.23841 19 9 19 308843;360243;94195;363465;58835;24614;259241;24552;170496;288001;64194;25663;24426;25283;25317;24309;25426;289185;310395 TSKU_10094;TOP2A_10059;S100A9_9775;PIR_9487;PHGDH_9470;ORM1_9400;NR1D2_9358;ME1_9215;LCN2_32481;KNG1L1_32433;INSIG1_8906;IL1R1_8893;GSTP1_8762;GCLC_8699;FGF1_8633;DBP_8439;CYP1B1_32710;CREG1_8380;CCRN4L_8232 268.81265105263185 122.514 332.84606557832456 173.9534815789476 56.4566 236.11781563123404 636.1951263157897 280.185 976.5719345893622 92.2997;4.48597E-12;963.318;152.213;122.826;662.49;9.46041;13.1175;972.626;3.87556;37.6554;76.6218;122.514;145.958;674.162;66.0377;229.313;97.6763;665.276 49.0864;4.48597E-12;802.143;56.4566;67.6778;432.445;2.2133;6.20444;551.931;1.25511;13.2791;27.5215;84.8469;96.7058;437.622;19.9899;185.32;36.7323;433.686 185.899;4.48599E-12;1158.68;371.778;246.456;1413.32;49.4216;28.4614;4084.57;13.8374;101.065;185.143;216.573;280.185;1465.0;280.428;299.27;282.14;1425.48 9 299270;316351;59107;24539;29200;24404;24890;298452;24207 SERPINA6_32325;NPAS2_9350;LTBP1_33264;LPL_32544;INHBA_33300;GPX1_33050;ESR1_33192;DPH2_8490;APOC3_32553 288.62793666666664 53.0014 387.86429852571285 162.56493444444445 14.3825 225.9777620144886 888.2827344444445 186.93 1262.5226661560296 25.7745;53.0014;769.394;900.118;91.8104;8.00432;12.5403;734.134;2.87451 8.17372;14.3825;438.027;487.466;44.1594;2.69961;3.74981;463.289;1.13737 103.274;215.15;2211.2;3428.38;186.93;25.2254;51.2968;1764.85;8.23841 0 Exp 2,2(0.08);Exp 4,7(0.25);Exp 5,1(0.04);Hill,9(0.33);Linear,6(0.22);Poly 2,3(0.11) 1.999655476533356 58.96814227104187 1.5140434503555298 5.5128583908081055 0.8407962848938916 1.7724979519844055 147.6629510389566 402.7007489610438 85.56174067592148 255.0240136097931 324.79396133241835 1109.6526108104395 UP 0.6785714285714286 0.32142857142857145 0.0 GO:0050896 2 response to stimulus 1203 1308 84 84 68 56 41 41 28 1267 1211 0.93115 0.10782 0.18137 3.13 360243;94195;287877;361042;24614;338475;316351;24567;313108;24552;29685;312538;59107;24539;170496;116682;288001;293502;64194;29200;25663;360504;24426;300850;116686;24404;29739;25283;25317;24890;25315;25426;24296;310395;54232;117517;81508;25612;24207;25748;114628 top2a;s100a9;pycr1;pck2;orm1;nrep;npas2;mt1;mms22l;me1;mcm6;mcm2;ltbp1;lpl;lcn2;kynu;kng1;kif22;insig1;inhba;il1r1;hba-a2;gstp1;gsta4;gsr;gpx1;gclm;gclc;fgf1;esr1;ephx1;cyp1b1;cyp1a1;noct;car3;c7;bhmt;asns;apoc3;alas2;abcg5 TOP2A_10059;S100A9_9775;PYCR1_9631;PCK2_9440;ORM1_9400;NREP_9364;NPAS2_9350;MT1A_9255;MMS22L_33129;ME1_9215;MCM6_9210;MCM2_9206;LTBP1_33264;LPL_32544;LCN2_32481;KYNU_8979;KNG1L1_32433;KIF22_8963;INSIG1_8906;INHBA_33300;IL1R1_8893;HBA2_32600;GSTP1_8762;GSTA4_8757;GSR_8755;GPX1_33050;GCLM_8700;GCLC_8699;FGF1_8633;ESR1_33192;EPHX1_8567;CYP1B1_32710;CYP1A1_8415;CCRN4L_8232;CAR3_8196;C7_8179;BHMT_8143;ASNS_8091;APOC3_32553;ALAS2_8019;ABCG5_7947 288001(0.1788) 227.20353380487816 91.8104 4.48597E-12 310.8392563610259 179.2780250532463 263.4391456289197 144.75962319512206 44.1594 4.48597E-12 206.27615108452758 113.90879825223284 171.35435017139577 534.4404587804879 186.93 4.48599E-12 902.3239237558231 418.43972072022774 772.8502815489966 4.48597E-12;963.318;132.668;6.67763;662.49;191.159;53.0014;818.334;4.13516;13.1175;1.87441;3.76863;769.394;900.118;972.626;100.381;3.87556;0.961856;37.6554;91.8104;76.6218;131.05;122.514;339.498;69.5519;8.00432;190.233;145.958;674.162;12.5403;27.5708;229.313;83.0393;665.276;3.44933;103.858;5.5396;6.05608;2.87451;125.506;565.363 4.48597E-12;802.143;90.3184;1.48195;432.445;115.886;14.3825;540.216;1.24709;6.20444;0.496857;0.956203;438.027;487.466;551.931;72.7231;1.25511;0.281971;13.2791;44.1594;27.5215;88.5948;84.8469;260.156;41.1016;2.69961;69.2223;96.7058;437.622;3.74981;12.6303;185.32;63.0271;433.686;2.13143;32.7314;1.97501;2.7438;1.13737;85.7907;386.851 4.48599E-12;1158.68;239.858;37.9425;1413.32;448.068;215.15;988.495;20.8956;28.4614;9.53;22.9217;2211.2;3428.38;4084.57;161.456;13.8374;4.47267;101.065;186.93;185.143;254.163;216.573;486.944;124.212;25.2254;496.452;280.185;1465.0;51.2968;61.9858;299.27;119.986;1425.48;6.02113;293.781;37.8319;14.3351;8.23841;236.762;1047.94 25 16 25 360243;94195;287877;361042;24614;313108;24552;29685;312538;170496;288001;293502;64194;25663;24426;300850;116686;29739;25283;25317;25315;25426;24296;310395;25612 TOP2A_10059;S100A9_9775;PYCR1_9631;PCK2_9440;ORM1_9400;MMS22L_33129;ME1_9215;MCM6_9210;MCM2_9206;LCN2_32481;KNG1L1_32433;KIF22_8963;INSIG1_8906;IL1R1_8893;GSTP1_8762;GSTA4_8757;GSR_8755;GCLM_8700;GCLC_8699;FGF1_8633;EPHX1_8567;CYP1B1_32710;CYP1A1_8415;CCRN4L_8232;ASNS_8091 217.3184810400002 76.6218 310.061259389568 144.66493684000017 41.1016 216.96776803483448 492.44480680000015 124.212 889.2261593702452 4.48597E-12;963.318;132.668;6.67763;662.49;4.13516;13.1175;1.87441;3.76863;972.626;3.87556;0.961856;37.6554;76.6218;122.514;339.498;69.5519;190.233;145.958;674.162;27.5708;229.313;83.0393;665.276;6.05608 4.48597E-12;802.143;90.3184;1.48195;432.445;1.24709;6.20444;0.496857;0.956203;551.931;1.25511;0.281971;13.2791;27.5215;84.8469;260.156;41.1016;69.2223;96.7058;437.622;12.6303;185.32;63.0271;433.686;2.7438 4.48599E-12;1158.68;239.858;37.9425;1413.32;20.8956;28.4614;9.53;22.9217;4084.57;13.8374;4.47267;101.065;185.143;216.573;486.944;124.212;496.452;280.185;1465.0;61.9858;299.27;119.986;1425.48;14.3351 16 338475;316351;24567;59107;24539;116682;29200;360504;24404;24890;54232;117517;81508;24207;25748;114628 NREP_9364;NPAS2_9350;MT1A_9255;LTBP1_33264;LPL_32544;KYNU_8979;INHBA_33300;HBA2_32600;GPX1_33050;ESR1_33192;CAR3_8196;C7_8179;BHMT_8143;APOC3_32553;ALAS2_8019;ABCG5_7947 242.64892875 102.1195 321.5867204676275 144.907570625 58.44125 195.31054743881265 600.058665 225.95600000000002 947.8818414989813 191.159;53.0014;818.334;769.394;900.118;100.381;91.8104;131.05;8.00432;12.5403;3.44933;103.858;5.5396;2.87451;125.506;565.363 115.886;14.3825;540.216;438.027;487.466;72.7231;44.1594;88.5948;2.69961;3.74981;2.13143;32.7314;1.97501;1.13737;85.7907;386.851 448.068;215.15;988.495;2211.2;3428.38;161.456;186.93;254.163;25.2254;51.2968;6.02113;293.781;37.8319;8.23841;236.762;1047.94 0 Exp 2,2(0.05);Exp 4,8(0.2);Exp 5,1(0.03);Hill,13(0.32);Linear,7(0.18);Poly 2,10(0.25) 2.090935210104353 93.47115290164948 1.5140434503555298 6.759152412414551 1.2229611510349077 1.7846373319625854 132.05545922810398 322.3516083816522 81.61837508968668 207.90087130055744 258.2385884150199 810.6423291459557 UP 0.6097560975609756 0.3902439024390244 0.0 GO:0051094 5 positive regulation of developmental process 376 396 21 21 18 11 8 8 61 388 2090 0.23152 0.86369 0.49907 2.02 192247;94195;24539;29200;25663;25317;25426;310395 sez6;s100a9;lpl;inhba;il1r1;fgf1;cyp1b1;noct SEZ6_9819;S100A9_9775;LPL_32544;INHBA_33300;IL1R1_8893;FGF1_8633;CYP1B1_32710;CCRN4L_8232 451.40729999999996 447.29449999999997 10.6392 391.3584093259054 411.7334301691421 339.9406773631928 302.73479625 309.503 3.96047 283.98512875903475 270.7528278355901 226.5102538706432 1022.2978375 728.975 29.4997 1138.5114071385167 934.3129922433586 1021.3048929425499 10.6392;963.318;900.118;91.8104;76.6218;674.162;229.313;665.276 3.96047;802.143;487.466;44.1594;27.5215;437.622;185.32;433.686 29.4997;1158.68;3428.38;186.93;185.143;1465.0;299.27;1425.48 5 3 5 94195;25663;25317;25426;310395 S100A9_9775;IL1R1_8893;FGF1_8633;CYP1B1_32710;CCRN4L_8232 521.7381600000001 665.276 361.41041135643553 377.2585 433.686 294.32592910751174 906.7146 1158.68 619.2619007502399 963.318;76.6218;674.162;229.313;665.276 802.143;27.5215;437.622;185.32;433.686 1158.68;185.143;1465.0;299.27;1425.48 3 192247;24539;29200 SEZ6_9819;LPL_32544;INHBA_33300 334.1892 91.8104 491.7862807454474 178.52862333333334 44.1594 268.30153842188014 1214.9365666666667 186.93 1918.5137344476746 10.6392;900.118;91.8104 3.96047;487.466;44.1594 29.4997;3428.38;186.93 0 Exp 2,1(0.13);Hill,3(0.38);Linear,3(0.38);Poly 2,1(0.13) 2.0953080216797892 17.655004858970642 1.5704141855239868 3.747737169265747 0.8204980839138699 1.7315708994865417 180.2097585934464 722.6048414065536 105.94314215438467 499.52645034561533 233.34968378303415 1811.2459912169659 UP 0.625 0.375 0.0 GO:0050777 6 negative regulation of immune response 45 49 3 3 3 2 2 2 67 47 2431 0.85455 0.38548 0.38548 4.08 24404;84586 gpx1;fgl2 GPX1_33050;FGL2_32918 77.20516 77.20516 8.00432 97.86476645561058 29.400789057991513 70.76013532412803 49.157605000000004 49.157605000000004 2.69961 65.70152660966143 17.064132923620935 47.50482816520237 175.1582 175.1582 25.2254 212.03699920457282 71.5836886562942 153.31122017486234 8.00432;146.406 2.69961;95.6156 25.2254;325.091 0 2 0 2 24404;84586 GPX1_33050;FGL2_32918 77.20516 77.20516 97.86476645561058 49.157605000000004 49.157605000000004 65.70152660966143 175.1582 175.1582 212.03699920457282 8.00432;146.406 2.69961;95.6156 25.2254;325.091 0 Hill,1(0.5);Poly 2,1(0.5) 1.720855719172849 3.44399094581604 1.6593536138534546 1.7846373319625854 0.0885889666472303 1.72199547290802 -58.4284864 212.8388064 -41.90006519999998 140.21527519999998 -118.71008799999998 469.02648800000003 DOWN 0.0 1.0 0.0 GO:0035296 6 regulation of tube diameter 54 57 7 7 7 4 4 4 65 53 2425 0.98227 0.066509 0.066509 7.02 288001;24404;29739;25283 kng1;gpx1;gclm;gclc KNG1L1_32433;GPX1_33050;GCLM_8700;GCLC_8699 288001(0.1788) 87.01772 76.98116 3.87556 95.36436577845767 86.64937749143247 95.35346776072299 42.470704999999995 35.960955 1.25511 48.08866336745803 42.069948370704005 47.88972423839453 203.92495 152.7052 13.8374 230.54607351742806 203.61502779790462 230.79962970741647 1.5 76.98116 3.87556;8.00432;190.233;145.958 1.25511;2.69961;69.2223;96.7058 13.8374;25.2254;496.452;280.185 3 1 3 288001;29739;25283 KNG1L1_32433;GCLM_8700;GCLC_8699 113.35552 145.958 97.3625448386144 55.727736666666665 69.2223 49.135384246355834 263.49146666666667 280.185 241.7399813325328 3.87556;190.233;145.958 1.25511;69.2223;96.7058 13.8374;496.452;280.185 1 24404 GPX1_33050 8.00432 8.00432 2.69961 2.69961 25.2254 25.2254 8.00432 2.69961 25.2254 0 Exp 4,1(0.25);Hill,2(0.5);Poly 2,1(0.25) 1.753222392514549 7.0293601751327515 1.5755720138549805 1.90879225730896 0.1375156271609644 1.7724979519844055 -6.4393584628885066 180.4747984628885 -4.656185100108871 89.59759510010886 -22.010202047079503 429.8601020470795 UP 0.75 0.25 0.0 GO:0097746 6 regulation of blood vessel diameter 54 57 7 7 7 4 4 4 65 53 2425 0.98227 0.066509 0.066509 7.02 288001;24404;29739;25283 kng1;gpx1;gclm;gclc KNG1L1_32433;GPX1_33050;GCLM_8700;GCLC_8699 288001(0.1788) 87.01772 76.98116 3.87556 95.36436577845767 86.64937749143247 95.35346776072299 42.470704999999995 35.960955 1.25511 48.08866336745803 42.069948370704005 47.88972423839453 203.92495 152.7052 13.8374 230.54607351742806 203.61502779790462 230.79962970741647 1.5 76.98116 3.87556;8.00432;190.233;145.958 1.25511;2.69961;69.2223;96.7058 13.8374;25.2254;496.452;280.185 3 1 3 288001;29739;25283 KNG1L1_32433;GCLM_8700;GCLC_8699 113.35552 145.958 97.3625448386144 55.727736666666665 69.2223 49.135384246355834 263.49146666666667 280.185 241.7399813325328 3.87556;190.233;145.958 1.25511;69.2223;96.7058 13.8374;496.452;280.185 1 24404 GPX1_33050 8.00432 8.00432 2.69961 2.69961 25.2254 25.2254 8.00432 2.69961 25.2254 0 Exp 4,1(0.25);Hill,2(0.5);Poly 2,1(0.25) 1.753222392514549 7.0293601751327515 1.5755720138549805 1.90879225730896 0.1375156271609644 1.7724979519844055 -6.4393584628885066 180.4747984628885 -4.656185100108871 89.59759510010886 -22.010202047079503 429.8601020470795 UP 0.75 0.25 0.0 GO:0009612 4 response to mechanical stimulus 121 126 7 7 5 6 4 4 65 122 2356 0.74622 0.44797 0.77458 3.17 59107;116686;25283;25612 ltbp1;gsr;gclc;asns LTBP1_33264;GSR_8755;GCLC_8699;ASNS_8091 247.739995 107.75495000000001 6.05608 352.4412893935558 150.80502013187618 247.1065208249947 144.64454999999998 68.9037 2.7438 199.35592212993492 90.43307891812685 140.60360578337887 657.483025 202.1985 14.3351 1041.5385218685556 361.08760545820866 727.1375740367401 769.394;69.5519;145.958;6.05608 438.027;41.1016;96.7058;2.7438 2211.2;124.212;280.185;14.3351 3 1 3 116686;25283;25612 GSR_8755;GCLC_8699;ASNS_8091 73.85532666666667 69.5519 70.0501707044896 46.8504 41.1016 47.244056632342655 139.57736666666668 124.212 133.58934539140213 69.5519;145.958;6.05608 41.1016;96.7058;2.7438 124.212;280.185;14.3351 1 59107 LTBP1_33264 769.394 769.394 438.027 438.027 2211.2 2211.2 769.394 438.027 2211.2 0 Exp 2,1(0.25);Exp 4,1(0.25);Hill,1(0.25);Poly 2,1(0.25) 2.0324891083659495 8.619428753852844 1.5140434503555298 3.5324413776397705 0.9275702331668917 1.786471962928772 -97.65246860568459 593.1324586056846 -50.72425368733619 340.01335368733623 -363.2247264311844 1678.1907764311845 UP 0.75 0.25 0.0 GO:0042744 6 hydrogen peroxide catabolic process 11 11 4 4 4 3 3 3 66 8 2470 0.99986 0.0026873 0.0026873 27.27 287167;360504;24404 hba-a1;hba-a2;gpx1 LOC287167_9118;HBA2_32600;GPX1_33050 96.11210666666666 131.05 8.00432 76.84619710482842 99.37580803462107 76.51261079543778 62.76560333333333 88.5948 2.69961 52.18826113964742 64.79222671363733 51.794496084114236 204.51346666666666 254.163 25.2254 160.33626591340257 213.26994241080854 161.3988387624925 0.0 8.00432 0.5 69.52716000000001 149.282;131.05;8.00432 97.0024;88.5948;2.69961 334.152;254.163;25.2254 0 3 0 3 287167;360504;24404 LOC287167_9118;HBA2_32600;GPX1_33050 96.11210666666666 131.05 76.84619710482842 62.76560333333333 88.5948 52.18826113964742 204.51346666666666 254.163 160.33626591340257 149.282;131.05;8.00432 97.0024;88.5948;2.69961 334.152;254.163;25.2254 0 Hill,1(0.34);Poly 2,2(0.67) 1.8232509190766826 5.4760541915893555 1.743384599685669 1.948032259941101 0.10822842760987678 1.7846373319625854 9.152448400710128 183.07176493262324 3.7090263630060463 121.82218030366062 23.075901546180347 385.95103178715294 DOWN 0.0 1.0 0.0 GO:0098754 2 detoxification 44 58 12 12 9 10 8 8 61 50 2428 0.99998 1.2516E-4 1.2516E-4 13.79 94195;24567;287167;360504;24426;116686;24404;26760 s100a9;mt1;hba-a1;hba-a2;gstp1;gsr;gpx1;akr7a3 S100A9_9775;MT1A_9255;LOC287167_9118;HBA2_32600;GSTP1_8762;GSR_8755;GPX1_33050;AKR7A3_8015 289.89636499999995 126.78200000000001 8.00432 375.6833082587089 164.71092073588258 258.52283383221294 211.20886375 86.72085000000001 2.69961 294.143010935923 115.72679732452842 203.76373958721467 400.55617500000005 235.368 25.2254 428.60628039064255 265.8856848521316 304.6582759153948 1.5 63.3343 4.5 140.166 963.318;818.334;149.282;131.05;122.514;69.5519;8.00432;57.1167 802.143;540.216;97.0024;88.5948;84.8469;41.1016;2.69961;33.0666 1158.68;988.495;334.152;254.163;216.573;124.212;25.2254;102.949 4 4 4 94195;24426;116686;26760 S100A9_9775;GSTP1_8762;GSR_8755;AKR7A3_8015 303.12514999999996 96.03295 441.0410439261521 240.28952500000003 62.97425 375.259424553125 400.60350000000005 170.3925 507.78527857911234 963.318;122.514;69.5519;57.1167 802.143;84.8469;41.1016;33.0666 1158.68;216.573;124.212;102.949 4 24567;287167;360504;24404 MT1A_9255;LOC287167_9118;HBA2_32600;GPX1_33050 276.66758 140.166 366.5214970623309 182.1282025 92.7986 242.49837811102165 400.50885 294.1575 413.273807456941 818.334;149.282;131.05;8.00432 540.216;97.0024;88.5948;2.69961 988.495;334.152;254.163;25.2254 0 Exp 4,1(0.13);Hill,2(0.25);Poly 2,5(0.63) 2.440041859299341 22.04890489578247 1.7056305408477783 5.5128583908081055 1.6206872676965347 1.8803088068962097 29.56111444863751 550.2316155513627 7.3781564320084385 415.0395710679915 103.54717582310116 697.5651741768988 CONFLICT 0.5 0.5 0.0 GO:0048732 5 gland development 137 157 12 12 10 8 6 6 63 151 2327 0.8708 0.24966 0.31572 3.82 25315;24309;25426;24296;25612;25748 ephx1;dbp;cyp1b1;cyp1a1;asns;alas2 EPHX1_8567;DBP_8439;CYP1B1_32710;CYP1A1_8415;ASNS_8091;ALAS2_8019 89.58714666666667 74.5385 6.05608 80.29245942320776 97.46699462000674 83.97743070605564 61.58363333333333 41.5085 2.7438 68.53808808572548 67.82640359401373 73.98735126280532 168.79448333333332 178.374 14.3351 119.79444878211038 180.1558372589175 116.46414140077351 27.5708;66.0377;229.313;83.0393;6.05608;125.506 12.6303;19.9899;185.32;63.0271;2.7438;85.7907 61.9858;280.428;299.27;119.986;14.3351;236.762 5 1 5 25315;24309;25426;24296;25612 EPHX1_8567;DBP_8439;CYP1B1_32710;CYP1A1_8415;ASNS_8091 82.40337600000001 66.0377 87.58738261216554 56.742219999999996 19.9899 75.47212912775815 155.20098 119.986 128.656567854937 27.5708;66.0377;229.313;83.0393;6.05608 12.6303;19.9899;185.32;63.0271;2.7438 61.9858;280.428;299.27;119.986;14.3351 1 25748 ALAS2_8019 125.506 125.506 85.7907 85.7907 236.762 236.762 125.506 85.7907 236.762 0 Exp 4,1(0.17);Hill,2(0.34);Linear,1(0.17);Poly 2,2(0.34) 3.002075073890156 19.761412620544434 1.7586312294006348 6.292444229125977 1.6367111238985352 3.1376439332962036 25.339798445205886 153.83449488812744 6.741741039721511 116.42552562694513 72.93896064551292 264.6500060211538 UP 0.8333333333333334 0.16666666666666666 0.0 GO:0071229 5 cellular response to acid chemical 95 99 8 8 6 6 4 4 65 95 2383 0.87224 0.27939 0.34183 4.04 24614;24539;29739;25283 orm1;lpl;gclm;gclc ORM1_9400;LPL_32544;GCLM_8700;GCLC_8699 474.69975 426.3615 145.958 367.5315566844794 404.25720992819237 366.5645385530619 271.45977500000004 264.5754 69.2223 219.09958160596557 223.90520672494537 214.8613907943737 1404.5842499999999 954.886 280.185 1435.8276832471636 1225.050478114268 1441.3328495757505 662.49;900.118;190.233;145.958 432.445;487.466;69.2223;96.7058 1413.32;3428.38;496.452;280.185 3 1 3 24614;29739;25283 ORM1_9400;GCLM_8700;GCLC_8699 332.89366666666666 190.233 286.29595895913957 199.45770000000002 96.7058 202.24032032220973 729.9856666666666 496.452 601.5830883230789 662.49;190.233;145.958 432.445;69.2223;96.7058 1413.32;496.452;280.185 1 24539 LPL_32544 900.118 900.118 487.466 487.466 3428.38 3428.38 900.118 487.466 3428.38 0 Exp 2,1(0.25);Hill,1(0.25);Linear,1(0.25);Poly 2,1(0.25) 1.7255720088572086 6.921590089797974 1.5487829446792603 1.90879225730896 0.1487966094009567 1.7320074439048767 114.51882444921017 834.8806755507899 56.74218502615372 486.17736497384624 -2.52687958222009 2811.69537958222 UP 0.75 0.25 0.0 GO:0033189 6 response to vitamin A 20 20 3 3 3 3 3 3 66 17 2461 0.99828 0.015593 0.015593 15.0 116686;24296;24207 gsr;cyp1a1;apoc3 GSR_8755;CYP1A1_8415;APOC3_32553 51.82190333333333 69.5519 2.87451 42.922755914386876 49.04240271273712 44.97875187741861 35.08868999999999 41.1016 1.13737 31.37994558423102 33.95326310452961 33.292098083395196 84.14547 119.986 8.23841 65.7713926215851 78.24992162872627 67.55397269509314 0.0 2.87451 1.0 69.5519 69.5519;83.0393;2.87451 41.1016;63.0271;1.13737 124.212;119.986;8.23841 2 1 2 116686;24296 GSR_8755;CYP1A1_8415 76.29560000000001 76.29560000000001 9.53703200057533 52.06435 52.06435 15.503669730905642 122.099 122.099 2.9882332572944037 69.5519;83.0393 41.1016;63.0271 124.212;119.986 1 24207 APOC3_32553 2.87451 2.87451 1.13737 1.13737 8.23841 8.23841 2.87451 1.13737 8.23841 0 Exp 4,2(0.67);Poly 2,1(0.34) 2.5901460536506553 9.628573298454285 1.5235437154769897 6.292444229125977 2.6737954521669756 1.8125853538513184 3.250232557530879 100.3935741091358 -0.42106125921471715 70.59844125921472 9.718132779304483 158.57280722069552 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0071310 5 cellular response to organic substance 516 551 37 37 30 26 19 19 50 532 1946 0.90948 0.14518 0.23593 3.45 361042;24614;312538;59107;24539;170496;64194;29200;25663;24426;24404;29739;25283;24890;25315;25426;24296;25612;24207 pck2;orm1;mcm2;ltbp1;lpl;lcn2;insig1;inhba;il1r1;gstp1;gpx1;gclm;gclc;esr1;ephx1;cyp1b1;cyp1a1;asns;apoc3 PCK2_9440;ORM1_9400;MCM2_9206;LTBP1_33264;LPL_32544;LCN2_32481;INSIG1_8906;INHBA_33300;IL1R1_8893;GSTP1_8762;GPX1_33050;GCLM_8700;GCLC_8699;ESR1_33192;EPHX1_8567;CYP1B1_32710;CYP1A1_8415;ASNS_8091;APOC3_32553 228.90869315789473 83.0393 2.87451 328.3184809561014 154.71093078310477 267.9045210844628 132.59737594736842 44.1594 0.956203 190.00048558785278 91.44126463701045 155.55877294204632 697.1063005263159 185.143 8.23841 1216.9134032191005 454.3269181054918 1020.7280250234301 6.67763;662.49;3.76863;769.394;900.118;972.626;37.6554;91.8104;76.6218;122.514;8.00432;190.233;145.958;12.5403;27.5708;229.313;83.0393;6.05608;2.87451 1.48195;432.445;0.956203;438.027;487.466;551.931;13.2791;44.1594;27.5215;84.8469;2.69961;69.2223;96.7058;3.74981;12.6303;185.32;63.0271;2.7438;1.13737 37.9425;1413.32;22.9217;2211.2;3428.38;4084.57;101.065;186.93;185.143;216.573;25.2254;496.452;280.185;51.2968;61.9858;299.27;119.986;14.3351;8.23841 13 6 13 361042;24614;312538;170496;64194;25663;24426;29739;25283;25315;25426;24296;25612 PCK2_9440;ORM1_9400;MCM2_9206;LCN2_32481;INSIG1_8906;IL1R1_8893;GSTP1_8762;GCLM_8700;GCLC_8699;EPHX1_8567;CYP1B1_32710;CYP1A1_8415;ASNS_8091 197.27104923076925 83.0393 291.4210161883603 118.62391946153846 63.0271 175.46790896464313 564.1345461538461 185.143 1120.6508668300798 6.67763;662.49;3.76863;972.626;37.6554;76.6218;122.514;190.233;145.958;27.5708;229.313;83.0393;6.05608 1.48195;432.445;0.956203;551.931;13.2791;27.5215;84.8469;69.2223;96.7058;12.6303;185.32;63.0271;2.7438 37.9425;1413.32;22.9217;4084.57;101.065;185.143;216.573;496.452;280.185;61.9858;299.27;119.986;14.3351 6 59107;24539;29200;24404;24890;24207 LTBP1_33264;LPL_32544;INHBA_33300;GPX1_33050;ESR1_33192;APOC3_32553 297.4569216666667 52.17535 419.51270786334845 162.87319833333333 23.954605 233.36554015582036 985.2117683333332 119.1134 1473.6091661237567 769.394;900.118;91.8104;8.00432;12.5403;2.87451 438.027;487.466;44.1594;2.69961;3.74981;1.13737 2211.2;3428.38;186.93;25.2254;51.2968;8.23841 0 Exp 2,2(0.11);Exp 4,1(0.06);Exp 5,1(0.06);Hill,9(0.48);Linear,3(0.16);Poly 2,3(0.16) 2.1724983008941137 45.95492351055145 1.5140434503555298 6.292444229125977 1.3735673427840032 1.7846373319625854 81.27869966434315 376.53868665144637 47.162738307043796 218.0320135876931 149.91530087170747 1244.2973001809241 UP 0.6842105263157895 0.3157894736842105 0.0 GO:0050714 7 positive regulation of protein secretion 92 99 4 4 3 4 3 3 66 96 2382 0.72061 0.5075 0.74918 3.03 361042;24614;24539 pck2;orm1;lpl PCK2_9440;ORM1_9400;LPL_32544 523.0952100000001 662.49 6.67763 462.7441023889903 307.1760563085329 483.6414972647069 307.1309833333333 432.445 1.48195 266.1255836883235 175.5308014232162 276.33726871849717 1626.5475 1413.32 37.9425 1705.2466347771367 1019.4052709829087 1718.4975843276654 6.67763;662.49;900.118 1.48195;432.445;487.466 37.9425;1413.32;3428.38 2 1 2 361042;24614 PCK2_9440;ORM1_9400 334.583815 334.583815 463.72937401302113 216.963475 216.963475 304.73689509583716 725.63125 725.63125 972.5387569414006 6.67763;662.49 1.48195;432.445 37.9425;1413.32 1 24539 LPL_32544 900.118 900.118 487.466 487.466 3428.38 3428.38 900.118 487.466 3428.38 0 Exp 2,1(0.34);Hill,1(0.34);Linear,1(0.34) 1.5919337420506805 4.781421422958374 1.528982162475586 1.7036563158035278 0.09564595469761193 1.5487829446792603 -0.5490368771828571 1046.7394568771829 5.981535667161722 608.2804309995049 -303.12072310163535 3556.2157231016354 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0009890 6 negative regulation of biosynthetic process 293 306 15 15 11 9 6 6 63 300 2178 0.25916 0.85437 0.57133 1.96 259241;64194;24426;25283;24890;24207 nr1d2;insig1;gstp1;gclc;esr1;apoc3 NR1D2_9358;INSIG1_8906;GSTP1_8762;GCLC_8699;ESR1_33192;APOC3_32553 55.16710333333333 25.09785 2.87451 62.81068803510137 34.360741575414586 53.76912792603512 33.65538 8.514455 1.13737 44.61275255986028 19.164326583048172 37.08030447012958 117.796635 76.1809 8.23841 107.24465218479547 82.86716550329032 96.10648591327023 9.46041;37.6554;122.514;145.958;12.5403;2.87451 2.2133;13.2791;84.8469;96.7058;3.74981;1.13737 49.4216;101.065;216.573;280.185;51.2968;8.23841 4 2 4 259241;64194;24426;25283 NR1D2_9358;INSIG1_8906;GSTP1_8762;GCLC_8699 78.8969525 80.0847 65.63009983074096 49.261275 49.063 48.392659665309786 161.81115 158.81900000000002 105.40830812965677 9.46041;37.6554;122.514;145.958 2.2133;13.2791;84.8469;96.7058 49.4216;101.065;216.573;280.185 2 24890;24207 ESR1_33192;APOC3_32553 7.707405 7.707405 6.834745654525119 2.44359 2.44359 1.847274039442984 29.767605 29.767605 30.446879555975023 12.5403;2.87451 3.74981;1.13737 51.2968;8.23841 0 Exp 4,1(0.17);Exp 5,1(0.17);Hill,2(0.34);Poly 2,2(0.34) 2.1876838593739003 14.672163009643555 1.5235437154769897 5.5128583908081055 1.5191369359448348 1.8634472489356995 4.908085547482592 105.42612111918407 -2.042256732282574 69.35301673228255 31.983041004964704 203.6102289950353 UP 0.6666666666666666 0.3333333333333333 0.0 GO:1901701 5 cellular response to oxygen-containing compound 359 378 33 33 26 22 16 16 53 362 2116 0.9795 0.041063 0.05774 4.23 361042;24614;24567;59107;24539;170496;64194;29200;25663;24426;24404;29739;25283;24890;25426;24207 pck2;orm1;mt1;ltbp1;lpl;lcn2;insig1;inhba;il1r1;gstp1;gpx1;gclm;gclc;esr1;cyp1b1;apoc3 PCK2_9440;ORM1_9400;MT1A_9255;LTBP1_33264;LPL_32544;LCN2_32481;INSIG1_8906;INHBA_33300;IL1R1_8893;GSTP1_8762;GPX1_33050;GCLM_8700;GCLC_8699;ESR1_33192;CYP1B1_32710;APOC3_32553 315.4477725 134.236 2.87451 365.6689106146963 203.224490663665 309.2247754625428 186.26304625 77.03460000000001 1.13737 218.54865593839637 119.93850465256276 182.0370746863877 875.8928818750001 248.37900000000002 8.23841 1279.8993185650527 589.5668558622093 1146.8033466758204 6.67763;662.49;818.334;769.394;900.118;972.626;37.6554;91.8104;76.6218;122.514;8.00432;190.233;145.958;12.5403;229.313;2.87451 1.48195;432.445;540.216;438.027;487.466;551.931;13.2791;44.1594;27.5215;84.8469;2.69961;69.2223;96.7058;3.74981;185.32;1.13737 37.9425;1413.32;988.495;2211.2;3428.38;4084.57;101.065;186.93;185.143;216.573;25.2254;496.452;280.185;51.2968;299.27;8.23841 9 7 9 361042;24614;170496;64194;25663;24426;29739;25283;25426 PCK2_9440;ORM1_9400;LCN2_32481;INSIG1_8906;IL1R1_8893;GSTP1_8762;GCLM_8700;GCLC_8699;CYP1B1_32710 271.5654255555555 145.958 326.6466357369779 162.52817222222222 84.8469 197.0152427283025 790.5022777777779 280.185 1302.1380094143035 6.67763;662.49;972.626;37.6554;76.6218;122.514;190.233;145.958;229.313 1.48195;432.445;551.931;13.2791;27.5215;84.8469;69.2223;96.7058;185.32 37.9425;1413.32;4084.57;101.065;185.143;216.573;496.452;280.185;299.27 7 24567;59107;24539;29200;24404;24890;24207 MT1A_9255;LTBP1_33264;LPL_32544;INHBA_33300;GPX1_33050;ESR1_33192;APOC3_32553 371.8679328571429 91.8104 430.60200125764646 216.77931285714288 44.1594 256.36688630078567 985.6808014285715 186.93 1345.2155410989988 818.334;769.394;900.118;91.8104;8.00432;12.5403;2.87451 540.216;438.027;487.466;44.1594;2.69961;3.74981;1.13737 988.495;2211.2;3428.38;186.93;25.2254;51.2968;8.23841 0 Exp 2,2(0.13);Exp 4,1(0.07);Exp 5,1(0.07);Hill,6(0.38);Linear,3(0.19);Poly 2,3(0.19) 1.9809013271856073 33.84827363491058 1.5140434503555298 5.5128583908081055 1.0001628578667545 1.7724979519844055 136.27000629879882 494.62553870120115 79.17420484018577 293.3518876598142 248.74221577812432 1503.043547971876 CONFLICT 0.5625 0.4375 0.0 GO:0050920 5 regulation of chemotaxis 65 68 2 2 2 2 2 2 67 66 2412 0.72061 0.55624 0.70687 2.94 24426;25317 gstp1;fgf1 GSTP1_8762;FGF1_8633 398.338 398.338 122.514 390.07404162799656 593.1570353809421 276.13193378977064 261.23445000000004 261.23445000000004 84.8469 249.44966544376237 385.819882537443 176.5844715396046 840.7865 840.7865 216.573 882.7711975163779 1281.6787789233776 624.9103807235091 122.514;674.162 84.8469;437.622 216.573;1465.0 2 0 2 24426;25317 GSTP1_8762;FGF1_8633 398.338 398.338 390.07404162799656 261.23445000000004 261.23445000000004 249.44966544376237 840.7865 840.7865 882.7711975163779 122.514;674.162 84.8469;437.622 216.573;1465.0 0 0 Linear,1(0.5);Poly 2,1(0.5) 2.942358071294177 7.083272576332092 1.5704141855239868 5.5128583908081055 2.7877290320060095 3.541636288166046 -142.2770399999999 938.9530399999999 -84.48514799999992 606.9540480000001 -382.6719599999999 2064.24496 UP 1.0 0.0 0.0 GO:0009967 6 positive regulation of signal transduction 363 381 17 17 13 10 7 7 62 374 2104 0.16742 0.9104 0.30665 1.84 94195;29200;25663;24404;25317;24890;25426 s100a9;inhba;il1r1;gpx1;fgf1;esr1;cyp1b1 S100A9_9775;INHBA_33300;IL1R1_8893;GPX1_33050;FGF1_8633;ESR1_33192;CYP1B1_32710 293.68140285714287 91.8104 8.00432 375.46425411175437 248.0970569661353 305.25816018761844 214.7450457142857 44.1594 2.69961 302.54771019377637 172.29274780405981 224.6617715010508 481.6493142857143 186.93 25.2254 581.2218279167184 456.52786147555037 583.4409467321609 963.318;91.8104;76.6218;8.00432;674.162;12.5403;229.313 802.143;44.1594;27.5215;2.69961;437.622;3.74981;185.32 1158.68;186.93;185.143;25.2254;1465.0;51.2968;299.27 4 3 4 94195;25663;25317;25426 S100A9_9775;IL1R1_8893;FGF1_8633;CYP1B1_32710 485.8537 451.7375 406.9054158554458 363.151625 311.471 337.9008393669596 777.02325 728.975 631.8080619900188 963.318;76.6218;674.162;229.313 802.143;27.5215;437.622;185.32 1158.68;185.143;1465.0;299.27 3 29200;24404;24890 INHBA_33300;GPX1_33050;ESR1_33192 37.45167333333333 12.5403 47.13063920907644 16.869606666666666 3.74981 23.639486989823475 87.8174 51.2968 86.81825892955926 91.8104;8.00432;12.5403 44.1594;2.69961;3.74981 186.93;25.2254;51.2968 0 Hill,4(0.58);Linear,2(0.29);Poly 2,1(0.15) 1.9370571569115627 13.962599515914917 1.5704141855239868 3.1843981742858887 0.5732616468726929 1.7318620681762695 15.533590936405346 571.8292147778805 -9.385434539050863 438.87552596762225 51.07415858130997 912.2244699901187 CONFLICT 0.5714285714285714 0.42857142857142855 0.0 GO:0001817 5 regulation of cytokine production 196 207 12 12 10 8 6 6 63 201 2277 0.67291 0.4951 0.82246 2.9 24614;59107;24539;25663;24426;25426 orm1;ltbp1;lpl;il1r1;gstp1;cyp1b1 ORM1_9400;LTBP1_33264;LPL_32544;IL1R1_8893;GSTP1_8762;CYP1B1_32710 460.0751333333333 445.9015 76.6218 359.03281292665525 376.0732221326089 332.05016733276153 275.93773333333337 308.8825 27.5215 200.9724198237327 236.3385923338144 181.2949437794618 1292.3143333333333 856.295 185.143 1325.967917986354 997.3153206554038 1299.549449133267 662.49;769.394;900.118;76.6218;122.514;229.313 432.445;438.027;487.466;27.5215;84.8469;185.32 1413.32;2211.2;3428.38;185.143;216.573;299.27 4 2 4 24614;25663;24426;25426 ORM1_9400;IL1R1_8893;GSTP1_8762;CYP1B1_32710 272.7347 175.9135 267.59494649182005 182.53334999999998 135.08345 178.91796479389657 528.5765 257.9215 591.789738749893 662.49;76.6218;122.514;229.313 432.445;27.5215;84.8469;185.32 1413.32;185.143;216.573;299.27 2 59107;24539 LTBP1_33264;LPL_32544 834.7560000000001 834.7560000000001 92.43582686382874 462.74649999999997 462.74649999999997 34.958652155082945 2819.79 2819.79 860.6762319246413 769.394;900.118 438.027;487.466 2211.2;3428.38 0 Exp 2,2(0.34);Hill,1(0.17);Linear,2(0.34);Poly 2,1(0.17) 2.2170174696231406 15.15690553188324 1.5140434503555298 5.5128583908081055 1.5939687247698313 1.6984112858772278 172.78905042176495 747.3612162449018 115.12630555942098 436.74916110724564 231.31902730673391 2353.3096393599326 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0006793 4 phosphorus metabolic process 386 422 20 19 17 9 7 7 62 415 2063 0.093282 0.95481 0.18769 1.66 83472;171497;116682;310395;54232;360887;296925 ugdh;sgk2;kynu;noct;car3;coq8a;aass UGDH_10131;SGK2_32380;KYNU_8979;CCRN4L_8232;CAR3_8196;ADCK3_7987;AASS_7936 216.53218428571427 100.381 3.44933 267.1414681749069 208.58750952527194 273.34090959279945 139.0898742857143 72.7231 2.13143 174.1239431384755 134.4912667942941 178.49319358361032 446.20419 161.456 6.02113 559.5138760640383 435.87188255360064 579.8087722170249 59.3662;156.37;100.381;665.276;3.44933;525.072;5.81076 25.4417;100.616;72.7231;433.686;2.13143;336.426;2.60489 135.068;343.205;161.456;1425.48;6.02113;1038.12;14.0792 3 4 3 83472;171497;310395 UGDH_10131;SGK2_32380;CCRN4L_8232 293.6707333333333 156.37 325.45397518606734 186.58123333333333 100.616 217.2748676841464 634.5843333333333 343.205 692.796665231822 59.3662;156.37;665.276 25.4417;100.616;433.686 135.068;343.205;1425.48 4 116682;54232;360887;296925 KYNU_8979;CAR3_8196;ADCK3_7987;AASS_7936 158.6782725 53.09588 248.39983662091345 103.471355 37.663995 158.80506496249092 304.91908249999994 87.76759999999999 493.9949610824486 100.381;3.44933;525.072;5.81076 72.7231;2.13143;336.426;2.60489 161.456;6.02113;1038.12;14.0792 0 Exp 2,1(0.15);Exp 4,1(0.15);Hill,2(0.29);Linear,1(0.15);Poly 2,2(0.29) 2.211537370414706 17.87975013256073 1.5737498998641968 6.759152412414551 1.872662095737031 1.8997833728790283 18.63101517994005 414.43335339148854 10.0970520487341 268.08269652269445 31.710510076527157 860.6978699234728 CONFLICT 0.42857142857142855 0.5714285714285714 0.0 GO:0009404 4 toxin metabolic process 12 17 4 4 3 4 3 3 66 14 2464 0.9991 0.0098563 0.0098563 17.65 25426;24296;26760 cyp1b1;cyp1a1;akr7a3 CYP1B1_32710;CYP1A1_8415;AKR7A3_8015 123.15633333333334 83.0393 57.1167 92.84354423449878 142.29797355185568 93.54501894396228 93.80456666666667 63.0271 33.0666 80.65800514334165 111.31294398196323 79.99114001247608 174.0683333333333 119.986 102.949 108.76193196304183 194.8540313909122 111.74738197838568 0.0 57.1167 0.5 70.078 229.313;83.0393;57.1167 185.32;63.0271;33.0666 299.27;119.986;102.949 3 0 3 25426;24296;26760 CYP1B1_32710;CYP1A1_8415;AKR7A3_8015 123.15633333333334 83.0393 92.84354423449878 93.80456666666667 63.0271 80.65800514334165 174.0683333333333 119.986 108.76193196304183 229.313;83.0393;57.1167 185.32;63.0271;33.0666 299.27;119.986;102.949 0 0 Hill,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 4.707006108390317 14.681444644927979 3.1843981742858887 6.292444229125977 1.5771585706721416 5.204602241516113 18.093972630972033 228.21869403569468 2.5314415423258225 185.0776917910075 50.99262116829928 297.1440454983674 UP 1.0 0.0 0.0 GO:0048523 5 negative regulation of cellular process 938 999 54 53 43 32 24 24 45 975 1503 0.26261 0.81296 0.53222 2.4 308843;360243;192247;299270;287877;259241;316351;24567;312538;59107;24539;288001;64194;29200;24426;24404;29739;25283;84586;24890;25426;310395;25612;24207 tsku;top2a;sez6;serpina6;pycr1;nr1d2;npas2;mt1;mcm2;ltbp1;lpl;kng1;insig1;inhba;gstp1;gpx1;gclm;gclc;fgl2;esr1;cyp1b1;noct;asns;apoc3 TSKU_10094;TOP2A_10059;SEZ6_9819;SERPINA6_32325;PYCR1_9631;NR1D2_9358;NPAS2_9350;MT1A_9255;MCM2_9206;LTBP1_33264;LPL_32544;KNG1L1_32433;INSIG1_8906;INHBA_33300;GSTP1_8762;GPX1_33050;GCLM_8700;GCLC_8699;FGL2_32918;ESR1_33192;CYP1B1_32710;CCRN4L_8232;ASNS_8091;APOC3_32553 288001(0.1788) 186.5822670833335 72.4059 4.48597E-12 284.7876068251508 142.21661944630767 235.6448055400241 111.21753304166685 29.27095 4.48597E-12 173.25430436794116 86.79853931161848 144.97278731814794 454.9199212500002 186.4145 4.48599E-12 819.712329092678 341.27745756838607 693.6303707430876 92.2997;4.48597E-12;10.6392;25.7745;132.668;9.46041;53.0014;818.334;3.76863;769.394;900.118;3.87556;37.6554;91.8104;122.514;8.00432;190.233;145.958;146.406;12.5403;229.313;665.276;6.05608;2.87451 49.0864;4.48597E-12;3.96047;8.17372;90.3184;2.2133;14.3825;540.216;0.956203;438.027;487.466;1.25511;13.2791;44.1594;84.8469;2.69961;69.2223;96.7058;95.6156;3.74981;185.32;433.686;2.7438;1.13737 185.899;4.48599E-12;29.4997;103.274;239.858;49.4216;215.15;988.495;22.9217;2211.2;3428.38;13.8374;101.065;186.93;216.573;25.2254;496.452;280.185;325.091;51.2968;299.27;1425.48;14.3351;8.23841 13 11 13 308843;360243;287877;259241;312538;288001;64194;24426;29739;25283;25426;310395;25612 TSKU_10094;TOP2A_10059;PYCR1_9631;NR1D2_9358;MCM2_9206;KNG1L1_32433;INSIG1_8906;GSTP1_8762;GCLM_8700;GCLC_8699;CYP1B1_32710;CCRN4L_8232;ASNS_8091 126.0829061538465 92.2997 179.97969572342956 79.20256253846188 49.0864 120.0619029372358 257.33060000000035 185.899 380.5970813848001 92.2997;4.48597E-12;132.668;9.46041;3.76863;3.87556;37.6554;122.514;190.233;145.958;229.313;665.276;6.05608 49.0864;4.48597E-12;90.3184;2.2133;0.956203;1.25511;13.2791;84.8469;69.2223;96.7058;185.32;433.686;2.7438 185.899;4.48599E-12;239.858;49.4216;22.9217;13.8374;101.065;216.573;496.452;280.185;299.27;1425.48;14.3351 11 192247;299270;316351;24567;59107;24539;29200;24404;84586;24890;24207 SEZ6_9819;SERPINA6_32325;NPAS2_9350;MT1A_9255;LTBP1_33264;LPL_32544;INHBA_33300;GPX1_33050;FGL2_32918;ESR1_33192;APOC3_32553 258.0815118181818 53.0014 370.52172214777926 149.0534072727273 14.3825 220.98469847576095 688.4345736363637 186.93 1122.8865150325798 10.6392;25.7745;53.0014;818.334;769.394;900.118;91.8104;8.00432;146.406;12.5403;2.87451 3.96047;8.17372;14.3825;540.216;438.027;487.466;44.1594;2.69961;95.6156;3.74981;1.13737 29.4997;103.274;215.15;988.495;2211.2;3428.38;186.93;25.2254;325.091;51.2968;8.23841 0 Exp 2,2(0.09);Exp 4,3(0.13);Exp 5,1(0.05);Hill,11(0.46);Linear,2(0.09);Poly 2,5(0.21) 2.138891140672897 54.7106876373291 1.5140434503555298 5.5128583908081055 0.9582980834500812 1.8467147946357727 72.64349452430413 300.5210396423629 41.90137493942345 180.53369114391032 126.96668736624758 782.8731551337528 CONFLICT 0.5416666666666666 0.4583333333333333 0.0 GO:0001101 4 response to acid chemical 195 202 16 16 13 12 10 10 59 192 2286 0.98197 0.042761 0.064704 4.95 24614;24539;64194;24426;24404;29739;25283;25612;24207;25748 orm1;lpl;insig1;gstp1;gpx1;gclm;gclc;asns;apoc3;alas2 ORM1_9400;LPL_32544;INSIG1_8906;GSTP1_8762;GPX1_33050;GCLM_8700;GCLC_8699;ASNS_8091;APOC3_32553;ALAS2_8019 220.140931 124.00999999999999 2.87451 308.08833951284913 161.990613523955 277.08644128594045 127.63365800000001 77.03460000000001 1.13737 179.69835722161963 89.97382707137798 158.7278060992762 622.0535910000001 226.66750000000002 8.23841 1070.8671615441979 475.0202903221308 980.5584072689492 662.49;900.118;37.6554;122.514;8.00432;190.233;145.958;6.05608;2.87451;125.506 432.445;487.466;13.2791;84.8469;2.69961;69.2223;96.7058;2.7438;1.13737;85.7907 1413.32;3428.38;101.065;216.573;25.2254;496.452;280.185;14.3351;8.23841;236.762 6 4 6 24614;64194;24426;29739;25283;25612 ORM1_9400;INSIG1_8906;GSTP1_8762;GCLM_8700;GCLC_8699;ASNS_8091 194.15108 134.236 239.4501060397042 116.54048333333333 77.03460000000001 159.40211443854085 420.3216833333333 248.37900000000002 513.7593276416515 662.49;37.6554;122.514;190.233;145.958;6.05608 432.445;13.2791;84.8469;69.2223;96.7058;2.7438 1413.32;101.065;216.573;496.452;280.185;14.3351 4 24539;24404;24207;25748 LPL_32544;GPX1_33050;APOC3_32553;ALAS2_8019 259.12570750000003 66.75516 431.0653364077192 144.27342 44.245155 232.18702805653135 924.6514525 130.9937 1672.3863814727993 900.118;8.00432;2.87451;125.506 487.466;2.69961;1.13737;85.7907 3428.38;25.2254;8.23841;236.762 0 Exp 2,1(0.1);Exp 4,1(0.1);Exp 5,1(0.1);Hill,3(0.3);Linear,1(0.1);Poly 2,3(0.3) 2.0943370266878096 23.000238060951233 1.5235437154769897 5.5128583908081055 1.2683471957881298 1.7724979519844055 29.185799813628677 411.09606218637134 16.255462280266556 239.0118537197334 -41.67675218399154 1285.7839341839913 UP 0.6 0.4 0.0 GO:0042752 4 regulation of circadian rhythm 33 35 5 5 4 5 4 4 65 31 2447 0.99782 0.013716 0.013716 11.43 360243;259241;316351;310395 top2a;nr1d2;npas2;noct TOP2A_10059;NR1D2_9358;NPAS2_9350;CCRN4L_8232 181.9344525000011 31.230905 4.48597E-12 323.05325872030625 192.75571251987176 339.44209042925036 112.57045000000112 8.2979 4.48597E-12 214.1703969166677 122.71424466765761 223.2421866811971 422.51290000000114 132.2858 4.48599E-12 674.9460829777236 431.7530563717366 715.4181996688287 0.5 4.730205000002242 2.5 359.1387 4.48597E-12;9.46041;53.0014;665.276 4.48597E-12;2.2133;14.3825;433.686 4.48599E-12;49.4216;215.15;1425.48 3 1 3 360243;259241;310395 TOP2A_10059;NR1D2_9358;CCRN4L_8232 224.91213666666815 9.46041 381.3956265306867 145.29976666666815 2.2133 249.75225595850517 491.63386666666815 49.4216 809.1119046169393 4.48597E-12;9.46041;665.276 4.48597E-12;2.2133;433.686 4.48599E-12;49.4216;1425.48 1 316351 NPAS2_9350 53.0014 53.0014 14.3825 14.3825 215.15 215.15 53.0014 14.3825 215.15 0 Hill,3(0.75);Linear,1(0.25) 2.0515722442624584 8.328776836395264 1.75295889377594 2.6413023471832275 0.4224554343329836 1.967257797718048 -134.657741045899 498.5266460459012 -97.31653897833324 322.45743897833546 -238.9342613181679 1083.9600613181701 UP 0.75 0.25 0.0 GO:2001235 7 positive regulation of apoptotic signaling pathway 58 59 2 2 2 2 2 2 67 57 2421 0.78657 0.47939 0.67349 3.39 94195;29200 s100a9;inhba S100A9_9775;INHBA_33300 527.5642 527.5642 91.8104 616.2489338156131 347.8764628166159 561.4155169219232 423.1512 423.1512 44.1594 535.9753435881915 266.86988024316105 488.28461692398355 672.8050000000001 672.8050000000001 186.93 687.1310146180275 472.44925025329275 625.9905577058408 963.318;91.8104 802.143;44.1594 1158.68;186.93 1 1 1 94195 S100A9_9775 963.318 963.318 802.143 802.143 1158.68 1158.68 963.318 802.143 1158.68 1 29200 INHBA_33300 91.8104 91.8104 44.1594 44.1594 186.93 186.93 91.8104 44.1594 186.93 0 Hill,1(0.5);Poly 2,1(0.5) 1.9774080495875077 3.998121500015259 1.7056305408477783 2.2924909591674805 0.4149729814038354 1.9990607500076294 -326.51324799999986 1381.6416479999998 -319.6727279999999 1165.975128 -279.50999999999976 1625.12 CONFLICT 0.5 0.5 0.0 GO:0045833 6 negative regulation of lipid metabolic process 31 34 6 6 4 5 3 3 66 31 2447 0.9876 0.062612 0.062612 8.82 64194;24890;24207 insig1;esr1;apoc3 INSIG1_8906;ESR1_33192;APOC3_32553 17.690070000000002 12.5403 2.87451 17.953207946985405 14.606565172398067 17.286674445198454 6.0554266666666665 3.74981 1.13737 6.390798307600806 5.00952875079814 6.0893958733232045 53.53340333333333 51.2968 8.23841 46.45369467125335 44.61211204369242 46.232524199552465 0.5 7.707405 37.6554;12.5403;2.87451 13.2791;3.74981;1.13737 101.065;51.2968;8.23841 1 2 1 64194 INSIG1_8906 37.6554 37.6554 13.2791 13.2791 101.065 101.065 37.6554 13.2791 101.065 2 24890;24207 ESR1_33192;APOC3_32553 7.707405 7.707405 6.834745654525119 2.44359 2.44359 1.847274039442984 29.767605 29.767605 30.446879555975023 12.5403;2.87451 3.74981;1.13737 51.2968;8.23841 0 Exp 4,1(0.34);Exp 5,1(0.34);Hill,1(0.34) 1.7312377033207258 5.221941709518433 1.5235437154769897 1.9665359258651733 0.22162673350273057 1.7318620681762695 -2.6258973043783307 38.00603730437834 -1.1764424148639971 13.28729574819733 0.9660992116637388 106.10070745500292 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0006464 6 cellular protein modification process 420 450 17 16 13 10 7 7 62 443 2035 0.060088 0.97275 0.10958 1.56 171497;94195;24404;171142;298452;81508;360887 sgk2;s100a9;gpx1;ehhadh;dph2;bhmt;coq8a SGK2_32380;S100A9_9775;GPX1_33050;EHHADH_8534;DPH2_8490;BHMT_8143;ADCK3_7987 365.61956 166.899 5.5396 378.4382105200415 263.407027430325 320.93238502963 258.91551714285714 105.26 1.97501 295.29822889726813 175.6796336638304 230.4559769030388 678.9386142857142 384.658 25.2254 655.2408625808691 556.5503356590876 649.8754082614327 156.37;963.318;8.00432;166.899;734.134;5.5396;525.072 100.616;802.143;2.69961;105.26;463.289;1.97501;336.426 343.205;1158.68;25.2254;384.658;1764.85;37.8319;1038.12 2 5 2 171497;94195 SGK2_32380;S100A9_9775 559.844 559.844 570.5984028649219 451.3795 451.3795 496.05449888545513 750.9425 750.9425 576.6279023881 156.37;963.318 100.616;802.143 343.205;1158.68 5 24404;171142;298452;81508;360887 GPX1_33050;EHHADH_8534;DPH2_8490;BHMT_8143;ADCK3_7987 287.92978400000004 166.899 327.14124055077076 181.92992399999997 105.26 208.21714682178754 650.13706 384.658 746.4963200511359 8.00432;166.899;734.134;5.5396;525.072 2.69961;105.26;463.289;1.97501;336.426 25.2254;384.658;1764.85;37.8319;1038.12 0 Exp 2,1(0.15);Exp 4,1(0.15);Hill,1(0.15);Linear,1(0.15);Poly 2,3(0.43) 1.6869847760910164 11.837972640991211 1.5039241313934326 1.8997833728790283 0.12830454657149193 1.6845101118087769 85.26861034070566 645.9705096592944 40.15552779005753 477.67550649565675 193.52939033951452 1164.3478382319138 DOWN 0.2857142857142857 0.7142857142857143 0.0 GO:0034641 4 cellular nitrogen compound metabolic process 478 543 39 39 36 29 26 26 43 517 1961 0.99951 0.0012139 0.0015493 4.79 83472;360243;266730;291317;293656;680308;313108;29685;312538;116682;293502;84029;24426;300850;116686;24404;29739;25283;499709;24890;25426;310395;81508;25612;25748;296925 ugdh;top2a;slc17a3;rpp38;rgd1307603;mthfd2;mms22l;mcm6;mcm2;kynu;kif22;hao2;gstp1;gsta4;gsr;gpx1;gclm;gclc;gar1;esr1;cyp1b1;noct;bhmt;asns;alas2;aass UGDH_10131;TOP2A_10059;SLC17A3_9840;RPP38_9741;RGD1307603_9684;MTHFD2_9261;MMS22L_33129;MCM6_9210;MCM2_9206;KYNU_8979;KIF22_8963;HAO2_8778;GSTP1_8762;GSTA4_8757;GSR_8755;GPX1_33050;GCLM_8700;GCLC_8699;GAR1_8683;ESR1_33192;CYP1B1_32710;CCRN4L_8232;BHMT_8143;ASNS_8091;ALAS2_8019;AASS_7936 499709(-0.07184) 179.5172929230771 81.4679 4.48597E-12 262.55596580044454 157.12371858653566 248.57378689617354 127.60760157692326 55.013400000000004 4.48597E-12 202.55790760392492 112.84078066300958 193.40125752567764 316.62036423076944 139.243 4.48599E-12 441.7148341145358 267.69804309457714 403.28737807729294 59.3662;4.48597E-12;93.3839;916.962;32.0155;622.58;4.13516;1.87441;3.76863;100.381;0.961856;140.856;122.514;339.498;69.5519;8.00432;190.233;145.958;765.364;12.5403;229.313;665.276;5.5396;6.05608;125.506;5.81076 25.4417;4.48597E-12;68.9252;769.912;12.3892;414.266;1.24709;0.496857;0.956203;72.7231;0.281971;93.5219;84.8469;260.156;41.1016;2.69961;69.2223;96.7058;587.034;3.74981;185.32;433.686;1.97501;2.7438;85.7907;2.60489 135.068;4.48599E-12;143.418;1051.72;78.5761;1250.29;20.8956;9.53;22.9217;161.456;4.47267;282.925;216.573;486.944;124.212;25.2254;496.452;280.185;1362.21;51.2968;299.27;1425.48;37.8319;14.3351;236.762;14.0792 17 9 17 83472;360243;266730;680308;313108;29685;312538;293502;24426;300850;116686;29739;25283;499709;25426;310395;25612 UGDH_10131;TOP2A_10059;SLC17A3_9840;MTHFD2_9261;MMS22L_33129;MCM6_9210;MCM2_9206;KIF22_8963;GSTP1_8762;GSTA4_8757;GSR_8755;GCLM_8700;GCLC_8699;GAR1_8683;CYP1B1_32710;CCRN4L_8232;ASNS_8091 195.28436094117674 93.3839 253.1265142787887 133.672436529412 68.9252 182.17648526747593 370.1327688235297 143.418 492.18467097705417 59.3662;4.48597E-12;93.3839;622.58;4.13516;1.87441;3.76863;0.961856;122.514;339.498;69.5519;190.233;145.958;765.364;229.313;665.276;6.05608 25.4417;4.48597E-12;68.9252;414.266;1.24709;0.496857;0.956203;0.281971;84.8469;260.156;41.1016;69.2223;96.7058;587.034;185.32;433.686;2.7438 135.068;4.48599E-12;143.418;1250.29;20.8956;9.53;22.9217;4.47267;216.573;486.944;124.212;496.452;280.185;1362.21;299.27;1425.48;14.3351 9 291317;293656;116682;84029;24404;24890;81508;25748;296925 RPP38_9741;RGD1307603_9684;KYNU_8979;HAO2_8778;GPX1_33050;ESR1_33192;BHMT_8143;ALAS2_8019;AASS_7936 149.73505333333333 32.0155 292.8338522544214 116.15180222222223 12.3892 248.2246673707909 215.54137777777777 78.5761 328.10714547857225 916.962;32.0155;100.381;140.856;8.00432;12.5403;5.5396;125.506;5.81076 769.912;12.3892;72.7231;93.5219;2.69961;3.74981;1.97501;85.7907;2.60489 1051.72;78.5761;161.456;282.925;25.2254;51.2968;37.8319;236.762;14.0792 0 Exp 2,1(0.04);Exp 4,5(0.2);Hill,9(0.35);Linear,4(0.16);Poly 2,7(0.27) 1.92685925486756 52.830071687698364 1.504341721534729 5.5128583908081055 0.8554376336451701 1.75807124376297 78.59402883337451 280.4405570127796 49.746848574243344 205.46835457960316 146.83064827526556 486.4100801862732 UP 0.6538461538461539 0.34615384615384615 0.0 GO:0051235 3 maintenance of location 47 50 5 5 5 3 3 3 66 47 2431 0.95541 0.15189 0.15189 6.0 59107;170496;64194 ltbp1;lcn2;insig1 LTBP1_33264;LCN2_32481;INSIG1_8906 593.2251333333334 769.394 37.6554 491.7510629404407 481.58620974580003 542.5061106968305 334.4123666666667 438.027 13.2791 283.8810693301041 269.50082433811247 312.92023489711426 2132.278333333333 2211.2 101.065 1992.9248589343085 1844.914744920398 2233.839504306118 1.5 871.01 769.394;972.626;37.6554 438.027;551.931;13.2791 2211.2;4084.57;101.065 2 1 2 170496;64194 LCN2_32481;INSIG1_8906 505.1407 505.1407 661.1240514700551 282.60505 282.60505 380.8844111890181 2092.8175 2092.8175 2816.763398390518 972.626;37.6554 551.931;13.2791 4084.57;101.065 1 59107 LTBP1_33264 769.394 769.394 438.027 438.027 2211.2 2211.2 769.394 438.027 2211.2 0 Exp 2,1(0.34);Exp 5,1(0.34);Linear,1(0.34) 1.7682757957051174 5.337570309638977 1.5140434503555298 1.9665359258651733 0.2360658530658016 1.856990933418274 36.75642054995512 1149.6938461167115 13.170695547340813 655.6540377859926 -122.92844607628967 4387.485112742957 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0044271 5 cellular nitrogen compound biosynthetic process 201 229 12 12 12 10 10 10 59 219 2259 0.95886 0.085745 0.12985 4.37 83472;116682;84029;29739;25283;499709;24890;25426;25612;25748 ugdh;kynu;hao2;gclm;gclc;gar1;esr1;cyp1b1;asns;alas2 UGDH_10131;KYNU_8979;HAO2_8778;GCLM_8700;GCLC_8699;GAR1_8683;ESR1_33192;CYP1B1_32710;ASNS_8091;ALAS2_8019 499709(-0.07184) 177.55735800000002 133.18099999999998 6.05608 218.57606801576597 150.26964423670995 152.08461778936334 122.225311 79.2569 2.7438 171.84288706339316 102.36339435557345 120.5263647079218 331.99599 258.4735 14.3351 387.46821050671 272.4282277856644 268.1604209775992 59.3662;100.381;140.856;190.233;145.958;765.364;12.5403;229.313;6.05608;125.506 25.4417;72.7231;93.5219;69.2223;96.7058;587.034;3.74981;185.32;2.7438;85.7907 135.068;161.456;282.925;496.452;280.185;1362.21;51.2968;299.27;14.3351;236.762 6 4 6 83472;29739;25283;499709;25426;25612 UGDH_10131;GCLM_8700;GCLC_8699;GAR1_8683;CYP1B1_32710;ASNS_8091 232.7150466666667 168.09550000000002 273.6721033116066 161.07793333333333 82.96405 218.20832386626927 431.25335 289.72749999999996 484.29722029507354 59.3662;190.233;145.958;765.364;229.313;6.05608 25.4417;69.2223;96.7058;587.034;185.32;2.7438 135.068;496.452;280.185;1362.21;299.27;14.3351 4 116682;84029;24890;25748 KYNU_8979;HAO2_8778;ESR1_33192;ALAS2_8019 94.820825 112.9435 57.334741191147224 63.9463775 79.2569 41.03877659505327 183.10995 199.10899999999998 101.13553074831484 100.381;140.856;12.5403;125.506 72.7231;93.5219;3.74981;85.7907 161.456;282.925;51.2968;236.762 0 Exp 2,1(0.1);Hill,4(0.4);Linear,1(0.1);Poly 2,4(0.4) 2.035062245297729 21.148446083068848 1.5737498998641968 3.5324413776397705 0.6796873210640937 1.8345754146575928 42.08250748099462 313.0322085190054 15.71598612739642 228.73463587260358 91.84070504228555 572.1512749577143 UP 0.6 0.4 0.0 GO:0009725 4 response to hormone 388 419 35 35 26 25 17 17 52 402 2076 0.97382 0.050155 0.069992 4.06 360243;361042;24614;24552;59107;64194;29200;360504;24426;24404;29739;25283;24890;25315;25426;25612;24207 top2a;pck2;orm1;me1;ltbp1;insig1;inhba;hba-a2;gstp1;gpx1;gclm;gclc;esr1;ephx1;cyp1b1;asns;apoc3 TOP2A_10059;PCK2_9440;ORM1_9400;ME1_9215;LTBP1_33264;INSIG1_8906;INHBA_33300;HBA2_32600;GSTP1_8762;GPX1_33050;GCLM_8700;GCLC_8699;ESR1_33192;EPHX1_8567;CYP1B1_32710;ASNS_8091;APOC3_32553 144.54464352941204 37.6554 4.48597E-12 227.62733125471834 91.4940384063925 153.89067465575323 87.24985764705909 13.2791 4.48597E-12 140.3912480343228 56.82021231351589 99.91138109477475 334.5084358823532 101.065 4.48599E-12 589.7813181773815 192.51368137458675 368.2386904943069 4.48597E-12;6.67763;662.49;13.1175;769.394;37.6554;91.8104;131.05;122.514;8.00432;190.233;145.958;12.5403;27.5708;229.313;6.05608;2.87451 4.48597E-12;1.48195;432.445;6.20444;438.027;13.2791;44.1594;88.5948;84.8469;2.69961;69.2223;96.7058;3.74981;12.6303;185.32;2.7438;1.13737 4.48599E-12;37.9425;1413.32;28.4614;2211.2;101.065;186.93;254.163;216.573;25.2254;496.452;280.185;51.2968;61.9858;299.27;14.3351;8.23841 11 6 11 360243;361042;24614;24552;64194;24426;29739;25283;25315;25426;25612 TOP2A_10059;PCK2_9440;ORM1_9400;ME1_9215;INSIG1_8906;GSTP1_8762;GCLM_8700;GCLC_8699;EPHX1_8567;CYP1B1_32710;ASNS_8091 131.05321909090952 37.6554 194.29011028831192 82.26178090909133 13.2791 129.86222988948995 268.14452727272766 101.065 410.427001171146 4.48597E-12;6.67763;662.49;13.1175;37.6554;122.514;190.233;145.958;27.5708;229.313;6.05608 4.48597E-12;1.48195;432.445;6.20444;13.2791;84.8469;69.2223;96.7058;12.6303;185.32;2.7438 4.48599E-12;37.9425;1413.32;28.4614;101.065;216.573;496.452;280.185;61.9858;299.27;14.3351 6 59107;29200;360504;24404;24890;24207 LTBP1_33264;INHBA_33300;HBA2_32600;GPX1_33050;ESR1_33192;APOC3_32553 169.27892166666666 52.17535 298.61944023485 96.39466499999999 23.954605 170.8436699800913 456.17560166666664 119.1134 865.2982805978589 769.394;91.8104;131.05;8.00432;12.5403;2.87451 438.027;44.1594;88.5948;2.69961;3.74981;1.13737 2211.2;186.93;254.163;25.2254;51.2968;8.23841 0 Exp 2,1(0.06);Exp 4,2(0.12);Exp 5,1(0.06);Hill,8(0.48);Linear,2(0.12);Poly 2,3(0.18) 2.1716827425025595 39.7569397687912 1.5140434503555298 5.5128583908081055 1.058781424662583 1.90879225730896 36.33747888942965 252.75180816939445 20.512094627453834 153.98762066666433 54.144193830102154 614.8726779346042 UP 0.6470588235294118 0.35294117647058826 0.0 GO:0010043 6 response to zinc ion 25 28 4 4 4 3 3 3 66 25 2453 0.99382 0.038426 0.038426 10.71 94195;24567;300850 s100a9;mt1;gsta4 S100A9_9775;MT1A_9255;GSTA4_8757 707.0499999999998 818.334 339.498 326.4597135819366 540.4562363847045 333.3406625660652 534.1716666666667 540.216 260.156 271.0440508779584 413.4049779837775 268.48508702218527 878.0396666666667 988.495 486.944 349.2242816877618 701.1296599073002 356.22787854419516 0.5 578.9159999999999 1.5 890.826 963.318;818.334;339.498 802.143;540.216;260.156 1158.68;988.495;486.944 2 1 2 94195;300850 S100A9_9775;GSTA4_8757 651.408 651.408 441.10735223979196 531.1495 531.1495 383.2426830149533 822.812 822.812 474.98908076712706 963.318;339.498 802.143;260.156 1158.68;486.944 1 24567 MT1A_9255 818.334 818.334 540.216 540.216 988.495 988.495 818.334 540.216 988.495 0 Linear,1(0.34);Poly 2,2(0.67) 1.911766577587016 5.795589327812195 1.7056305408477783 2.3371741771698 0.3518006152292419 1.7527846097946167 337.62605710844576 1076.4739428915543 227.45644942286015 840.8868839104731 482.85518990829974 1273.2241434250336 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0071702 5 organic substance transport 316 335 15 14 11 9 5 5 64 330 2148 0.091918 0.96022 0.20305 1.49 266730;29200;24207;301111;114628 slc17a3;inhba;apoc3;ano10;abcg5 SLC17A3_9840;INHBA_33300;APOC3_32553;ANO10_8049;ABCG5_7947 152.670502 91.8104 2.87451 234.70742227715135 187.77575217211063 263.7412865242623 100.797894 44.1594 1.13737 162.4524195056746 126.62432645901733 181.75693663314493 283.942942 143.418 8.23841 433.51503847102623 346.6020652014356 488.7171379527278 93.3839;91.8104;2.87451;9.9207;565.363 68.9252;44.1594;1.13737;2.9165;386.851 143.418;186.93;8.23841;33.1883;1047.94 2 3 2 266730;301111 SLC17A3_9840;ANO10_8049 51.6523 51.6523 59.01739469952906 35.92085 35.92085 46.67519938730846 88.30315 88.30315 77.94416835815879 93.3839;9.9207 68.9252;2.9165 143.418;33.1883 3 29200;24207;114628 INHBA_33300;APOC3_32553;ABCG5_7947 220.01597 91.8104 302.36703934107754 144.04925666666665 44.1594 211.36990961489678 414.36947000000004 186.93 555.9149066606711 91.8104;2.87451;565.363 44.1594;1.13737;386.851 186.93;8.23841;1047.94 0 Exp 4,1(0.2);Hill,2(0.4);Linear,1(0.2);Poly 2,1(0.2) 1.71327964978876 8.67917025089264 1.504341721534729 2.2924909591674805 0.3303785171346794 1.575217366218567 -53.05962440589988 358.40062840589985 -41.59793002460843 243.19371802460842 -96.04974335354319 663.9356273535432 DOWN 0.4 0.6 0.0 GO:0014070 5 response to organic cyclic compound 433 471 41 41 31 26 17 17 52 454 2024 0.92779 0.12162 0.20685 3.61 361042;24614;59107;116682;64194;29200;360504;24426;24404;29739;25283;24890;25315;25426;24296;25612;25748 pck2;orm1;ltbp1;kynu;insig1;inhba;hba-a2;gstp1;gpx1;gclm;gclc;esr1;ephx1;cyp1b1;cyp1a1;asns;alas2 PCK2_9440;ORM1_9400;LTBP1_33264;KYNU_8979;INSIG1_8906;INHBA_33300;HBA2_32600;GSTP1_8762;GPX1_33050;GCLM_8700;GCLC_8699;ESR1_33192;EPHX1_8567;CYP1B1_32710;CYP1A1_8415;ASNS_8091;ALAS2_8019 161.77607235294116 100.381 6.05608 219.63587543570506 111.3530800499295 149.76278621100462 99.84980411764705 69.2223 1.48195 135.0601678959068 71.27583844110146 97.34726684931756 362.83221176470585 186.93 14.3351 576.917596516399 225.05457535590918 364.0267528496066 6.67763;662.49;769.394;100.381;37.6554;91.8104;131.05;122.514;8.00432;190.233;145.958;12.5403;27.5708;229.313;83.0393;6.05608;125.506 1.48195;432.445;438.027;72.7231;13.2791;44.1594;88.5948;84.8469;2.69961;69.2223;96.7058;3.74981;12.6303;185.32;63.0271;2.7438;85.7907 37.9425;1413.32;2211.2;161.456;101.065;186.93;254.163;216.573;25.2254;496.452;280.185;51.2968;61.9858;299.27;119.986;14.3351;236.762 10 7 10 361042;24614;64194;24426;29739;25283;25315;25426;24296;25612 PCK2_9440;ORM1_9400;INSIG1_8906;GSTP1_8762;GCLM_8700;GCLC_8699;EPHX1_8567;CYP1B1_32710;CYP1A1_8415;ASNS_8091 151.15072100000003 102.77664999999999 195.6950377169865 96.170225 66.1247 131.03256278650153 304.11144 168.2795 416.8890746403204 6.67763;662.49;37.6554;122.514;190.233;145.958;27.5708;229.313;83.0393;6.05608 1.48195;432.445;13.2791;84.8469;69.2223;96.7058;12.6303;185.32;63.0271;2.7438 37.9425;1413.32;101.065;216.573;496.452;280.185;61.9858;299.27;119.986;14.3351 7 59107;116682;29200;360504;24404;24890;25748 LTBP1_33264;KYNU_8979;INHBA_33300;HBA2_32600;GPX1_33050;ESR1_33192;ALAS2_8019 176.95514571428572 100.381 265.9661455839082 105.10634571428571 72.7231 151.10999250425255 446.71902857142857 186.93 782.8829019644631 769.394;100.381;91.8104;131.05;8.00432;12.5403;125.506 438.027;72.7231;44.1594;88.5948;2.69961;3.74981;85.7907 2211.2;161.456;186.93;254.163;25.2254;51.2968;236.762 0 Exp 2,1(0.06);Exp 5,1(0.06);Hill,7(0.42);Linear,2(0.12);Poly 2,6(0.36) 2.294847347540127 43.31366288661957 1.5140434503555298 6.292444229125977 1.4053232067296673 1.948032259941101 57.36780466770743 266.1843400381749 35.64627573088126 164.05333250441288 88.58299482820087 637.0814287012108 CONFLICT 0.5882352941176471 0.4117647058823529 0.0 GO:0003006 3 developmental process involved in reproduction 220 234 9 9 8 5 4 4 65 230 2248 0.22513 0.89163 0.40263 1.71 29200;116686;24890;25426 inhba;gsr;esr1;cyp1b1 INHBA_33300;GSR_8755;ESR1_33192;CYP1B1_32710 100.8039 80.68115 12.5403 91.94676433317271 118.52697557487276 102.64695597942853 68.5827025 42.6305 3.74981 79.96376111952645 86.036695935956 89.54865451680095 165.4272 155.571 51.2968 105.04079593960942 181.3359589880753 115.24574204334307 91.8104;69.5519;12.5403;229.313 44.1594;41.1016;3.74981;185.32 186.93;124.212;51.2968;299.27 2 2 2 116686;25426 GSR_8755;CYP1B1_32710 149.43245 149.43245 112.96815717982213 113.21079999999999 113.21079999999999 101.97780861187398 211.74099999999999 211.74099999999999 123.78469890095462 69.5519;229.313 41.1016;185.32 124.212;299.27 2 29200;24890 INHBA_33300;ESR1_33192 52.17535 52.17535 56.052425255335734 23.954605 23.954605 28.573895113968096 119.1134 119.1134 95.90715547403126 91.8104;12.5403 44.1594;3.74981 186.93;51.2968 0 Exp 4,1(0.25);Hill,2(0.5);Linear,1(0.25) 2.1879464636984634 9.021336555480957 1.7318620681762695 3.1843981742858887 0.6669807859875664 2.0525381565093994 10.69607095349076 190.91172904650924 -9.78178339713594 146.94718839713593 62.48721997918274 268.3671800208172 CONFLICT 0.5 0.5 0.0 GO:0071548 6 response to dexamethasone 48 52 5 5 3 4 2 2 67 50 2428 0.83496 0.41448 0.65073 3.85 361042;25426 pck2;cyp1b1 PCK2_9440;CYP1B1_32710 117.99531499999999 117.99531499999999 6.67763 157.42697985897604 118.64708420351303 157.4242814223052 93.400975 93.400975 1.48195 129.99313179511157 93.93916432465173 129.99090359868612 168.60625 168.60625 37.9425 184.78644736052752 169.37129113668482 184.78327995855946 6.67763;229.313 1.48195;185.32 37.9425;299.27 2 0 2 361042;25426 PCK2_9440;CYP1B1_32710 117.99531499999999 117.99531499999999 157.42697985897604 93.400975 93.400975 129.99313179511157 168.60625 168.60625 184.78644736052752 6.67763;229.313 1.48195;185.32 37.9425;299.27 0 0 Hill,1(0.5);Linear,1(0.5) 2.2065556885569295 4.713380336761475 1.528982162475586 3.1843981742858887 1.1705558876358548 2.3566901683807373 -100.18734759999997 336.17797759999996 -86.760314 273.56226399999997 -87.49470000000002 424.7072 UP 1.0 0.0 0.0 GO:0065003 6 protein-containing complex assembly 203 233 10 10 9 4 3 3 66 230 2248 0.11037 0.95961 0.20418 1.29 83472;29685;312538 ugdh;mcm6;mcm2 UGDH_10131;MCM6_9210;MCM2_9206 21.66974666666667 3.76863 1.87441 32.65982184253664 15.72526162420763 29.443907564458755 8.964920000000001 0.956203 0.496857 14.271158294379228 6.415309771080014 12.832174398952352 55.8399 22.9217 9.53 68.93948998527623 42.103561392177966 63.05064188178709 59.3662;1.87441;3.76863 25.4417;0.496857;0.956203 135.068;9.53;22.9217 3 0 3 83472;29685;312538 UGDH_10131;MCM6_9210;MCM2_9206 21.66974666666667 3.76863 32.65982184253664 8.964920000000001 0.956203 14.271158294379228 55.8399 22.9217 68.93948998527623 59.3662;1.87441;3.76863 25.4417;0.496857;0.956203 135.068;9.53;22.9217 0 0 Hill,3(1) 1.6360942344497729 4.922975063323975 1.5280487537384033 1.8211764097213745 0.15770874803435725 1.5737498998641968 -15.288320920981878 58.62781425431521 -7.184415882498914 25.114255882498913 -22.172476877557685 133.8522768775577 UP 1.0 0.0 0.0 GO:0002682 4 regulation of immune system process 334 363 13 13 10 9 6 6 63 357 2121 0.11836 0.9431 0.22202 1.65 24614;29200;25663;24404;84586;117517 orm1;inhba;il1r1;gpx1;fgl2;c7 ORM1_9400;INHBA_33300;IL1R1_8893;GPX1_33050;FGL2_32918;C7_8179 181.53175333333334 97.83420000000001 8.00432 239.89816806821068 123.72622870491388 180.37673372402014 105.862085 38.4454 2.69961 162.9088412307931 61.9899002660938 122.35220593612102 404.9150666666667 240.3555 25.2254 505.0910146724317 293.33798056829255 380.9889957316102 662.49;91.8104;76.6218;8.00432;146.406;103.858 432.445;44.1594;27.5215;2.69961;95.6156;32.7314 1413.32;186.93;185.143;25.2254;325.091;293.781 2 4 2 24614;25663 ORM1_9400;IL1R1_8893 369.5559 369.5559 414.2713771015565 229.98325 229.98325 286.32415271179093 799.2315 799.2315 868.4522851973503 662.49;76.6218 432.445;27.5215 1413.32;185.143 4 29200;24404;84586;117517 INHBA_33300;GPX1_33050;FGL2_32918;C7_8179 87.51968 97.83420000000001 57.952975585419864 43.8015025 38.4454 38.71580868672846 207.75685000000001 240.3555 135.30083155628918 91.8104;8.00432;146.406;103.858 44.1594;2.69961;95.6156;32.7314 186.93;25.2254;325.091;293.781 0 Hill,4(0.67);Linear,1(0.17);Poly 2,1(0.17) 1.8031741282359213 10.909240007400513 1.5487829446792603 2.2924909591674805 0.265409228313225 1.7389017939567566 -10.426759985215313 373.490266651882 -24.492136630483515 236.21630663048353 0.7580818600573593 809.0720514732759 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0008152 2 metabolic process 1361 1509 96 94 81 63 51 51 18 1458 1020 0.99658 0.0073351 0.012652 3.38 83472;360243;266730;171497;299270;94195;291317;293656;287877;293820;363465;58835;361042;680308;313108;24552;29685;312538;24539;287167;116682;293502;64194;29200;360504;84029;24426;300850;116686;24404;29739;25283;499709;84586;24890;25315;171142;298452;25426;24296;290277;310395;54232;81508;25612;24207;25748;26760;286921;360887;296925 ugdh;top2a;slc17a3;sgk2;serpina6;s100a9;rpp38;rgd1307603;pycr1;psat1;pir;phgdh;pck2;mthfd2;mms22l;me1;mcm6;mcm2;lpl;hba-a1;kynu;kif22;insig1;inhba;hba-a2;hao2;gstp1;gsta4;gsr;gpx1;gclm;gclc;gar1;fgl2;esr1;ephx1;ehhadh;dph2;cyp1b1;cyp1a1;cryl1;noct;car3;bhmt;asns;apoc3;alas2;akr7a3;akr1b8;coq8a;aass UGDH_10131;TOP2A_10059;SLC17A3_9840;SGK2_32380;SERPINA6_32325;S100A9_9775;RPP38_9741;RGD1307603_9684;PYCR1_9631;PSAT1_9583;PIR_9487;PHGDH_9470;PCK2_9440;MTHFD2_9261;MMS22L_33129;ME1_9215;MCM6_9210;MCM2_9206;LPL_32544;LOC287167_9118;KYNU_8979;KIF22_8963;INSIG1_8906;INHBA_33300;HBA2_32600;HAO2_8778;GSTP1_8762;GSTA4_8757;GSR_8755;GPX1_33050;GCLM_8700;GCLC_8699;GAR1_8683;FGL2_32918;ESR1_33192;EPHX1_8567;EHHADH_8534;DPH2_8490;CYP1B1_32710;CYP1A1_8415;CRYL1_8388;CCRN4L_8232;CAR3_8196;BHMT_8143;ASNS_8091;APOC3_32553;ALAS2_8019;AKR7A3_8015;AKR1B8_8013;ADCK3_7987;AASS_7936 499709(-0.07184) 188.71438600000008 93.3839 4.48597E-12 266.9079981889318 153.63633833385035 234.9407494008551 126.1648872745099 63.0271 4.48597E-12 196.50723509895386 102.64412212485537 170.8445326820859 379.7580923529413 161.456 4.48599E-12 606.9941869967439 307.99356547380887 531.9762741418124 59.3662;4.48597E-12;93.3839;156.37;25.7745;963.318;916.962;32.0155;132.668;27.1579;152.213;122.826;6.67763;622.58;4.13516;13.1175;1.87441;3.76863;900.118;149.282;100.381;0.961856;37.6554;91.8104;131.05;140.856;122.514;339.498;69.5519;8.00432;190.233;145.958;765.364;146.406;12.5403;27.5708;166.899;734.134;229.313;83.0393;32.8011;665.276;3.44933;5.5396;6.05608;2.87451;125.506;57.1167;267.583;525.072;5.81076 25.4417;4.48597E-12;68.9252;100.616;8.17372;802.143;769.912;12.3892;90.3184;10.0144;56.4566;67.6778;1.48195;414.266;1.24709;6.20444;0.496857;0.956203;487.466;97.0024;72.7231;0.281971;13.2791;44.1594;88.5948;93.5219;84.8469;260.156;41.1016;2.69961;69.2223;96.7058;587.034;95.6156;3.74981;12.6303;105.26;463.289;185.32;63.0271;15.4462;433.686;2.13143;1.97501;2.7438;1.13737;85.7907;33.0666;114.994;336.426;2.60489 135.068;4.48599E-12;143.418;343.205;103.274;1158.68;1051.72;78.5761;239.858;103.876;371.778;246.456;37.9425;1250.29;20.8956;28.4614;9.53;22.9217;3428.38;334.152;161.456;4.47267;101.065;186.93;254.163;282.925;216.573;486.944;124.212;25.2254;496.452;280.185;1362.21;325.091;51.2968;61.9858;384.658;1764.85;299.27;119.986;74.622;1425.48;6.02113;37.8319;14.3351;8.23841;236.762;102.949;310.791;1038.12;14.0792 31 20 31 83472;360243;266730;171497;94195;287877;293820;363465;58835;361042;680308;313108;24552;29685;312538;293502;64194;24426;300850;116686;29739;25283;499709;25315;25426;24296;290277;310395;25612;26760;286921 UGDH_10131;TOP2A_10059;SLC17A3_9840;SGK2_32380;S100A9_9775;PYCR1_9631;PSAT1_9583;PIR_9487;PHGDH_9470;PCK2_9440;MTHFD2_9261;MMS22L_33129;ME1_9215;MCM6_9210;MCM2_9206;KIF22_8963;INSIG1_8906;GSTP1_8762;GSTA4_8757;GSR_8755;GCLM_8700;GCLC_8699;GAR1_8683;EPHX1_8567;CYP1B1_32710;CYP1A1_8415;CRYL1_8388;CCRN4L_8232;ASNS_8091;AKR7A3_8015;AKR1B8_8013 174.19188600000015 83.0393 246.7865926752951 118.05765519354854 56.4566 190.7174840361193 309.48105709677435 135.068 412.5869400906592 59.3662;4.48597E-12;93.3839;156.37;963.318;132.668;27.1579;152.213;122.826;6.67763;622.58;4.13516;13.1175;1.87441;3.76863;0.961856;37.6554;122.514;339.498;69.5519;190.233;145.958;765.364;27.5708;229.313;83.0393;32.8011;665.276;6.05608;57.1167;267.583 25.4417;4.48597E-12;68.9252;100.616;802.143;90.3184;10.0144;56.4566;67.6778;1.48195;414.266;1.24709;6.20444;0.496857;0.956203;0.281971;13.2791;84.8469;260.156;41.1016;69.2223;96.7058;587.034;12.6303;185.32;63.0271;15.4462;433.686;2.7438;33.0666;114.994 135.068;4.48599E-12;143.418;343.205;1158.68;239.858;103.876;371.778;246.456;37.9425;1250.29;20.8956;28.4614;9.53;22.9217;4.47267;101.065;216.573;486.944;124.212;496.452;280.185;1362.21;61.9858;299.27;119.986;74.622;1425.48;14.3351;102.949;310.791 20 299270;291317;293656;24539;287167;116682;29200;360504;84029;24404;84586;24890;171142;298452;54232;81508;24207;25748;360887;296925 SERPINA6_32325;RPP38_9741;RGD1307603_9684;LPL_32544;LOC287167_9118;KYNU_8979;INHBA_33300;HBA2_32600;HAO2_8778;GPX1_33050;FGL2_32918;ESR1_33192;EHHADH_8534;DPH2_8490;CAR3_8196;BHMT_8143;APOC3_32553;ALAS2_8019;ADCK3_7987;AASS_7936 211.224261 112.9435 300.7196125864386 138.731097 79.2569 209.55644569197284 488.68749700000006 211.846 824.7755880505717 25.7745;916.962;32.0155;900.118;149.282;100.381;91.8104;131.05;140.856;8.00432;146.406;12.5403;166.899;734.134;3.44933;5.5396;2.87451;125.506;525.072;5.81076 8.17372;769.912;12.3892;487.466;97.0024;72.7231;44.1594;88.5948;93.5219;2.69961;95.6156;3.74981;105.26;463.289;2.13143;1.97501;1.13737;85.7907;336.426;2.60489 103.274;1051.72;78.5761;3428.38;334.152;161.456;186.93;254.163;282.925;25.2254;325.091;51.2968;384.658;1764.85;6.02113;37.8319;8.23841;236.762;1038.12;14.0792 0 Exp 2,3(0.06);Exp 4,9(0.18);Exp 5,2(0.04);Hill,17(0.34);Linear,5(0.1);Poly 2,15(0.3) 2.0875647395992125 116.00104880332947 1.5039241313934326 6.759152412414551 1.1971245251571319 1.7846373319625854 115.46017899017805 261.96859300982214 72.23251440992084 180.097260139099 213.1655656031678 546.3506191027149 UP 0.6078431372549019 0.39215686274509803 0.0 GO:0090209 7 negative regulation of triglyceride metabolic process 8 8 3 3 2 3 2 2 67 6 2472 0.99903 0.018227 0.018227 25.0 24890;24207 esr1;apoc3 ESR1_33192;APOC3_32553 7.707405 7.707405 2.87451 6.834745654525119 6.683484057731202 6.679589805520749 2.44359 2.44359 1.13737 1.847274039442984 2.166847796163511 1.8053389936605937 29.767605 29.767605 8.23841 30.446879555975023 25.206323691242265 29.755703660656458 0.0 2.87451 0.0 2.87451 12.5403;2.87451 3.74981;1.13737 51.2968;8.23841 0 2 0 2 24890;24207 ESR1_33192;APOC3_32553 7.707405 7.707405 6.834745654525119 2.44359 2.44359 1.847274039442984 29.767605 29.767605 30.446879555975023 12.5403;2.87451 3.74981;1.13737 51.2968;8.23841 0 Exp 4,1(0.5);Hill,1(0.5) 1.624366821270041 3.2554057836532593 1.5235437154769897 1.7318620681762695 0.14730331983927167 1.6277028918266296 -1.765069200000001 17.179879200000002 -0.1166012000000003 5.003781200000001 -12.429617199999992 71.96482719999999 DOWN 0.0 1.0 0.0 GO:0071285 7 cellular response to lithium ion 14 15 1 1 1 1 1 1 68 14 2464 0.93948 0.33842 0.33842 6.67 300850 gsta4 GSTA4_8757 339.498 339.498 339.498 339.498 260.156 260.156 260.156 260.156 486.944 486.944 486.944 486.944 0.0 339.498 339.498 260.156 486.944 1 0 1 300850 GSTA4_8757 339.498 339.498 260.156 260.156 486.944 486.944 339.498 260.156 486.944 0 0 Linear,1(1) 1.7527846097946167 1.7527846097946167 1.7527846097946167 1.7527846097946167 0.0 1.7527846097946167 339.498 339.498 260.156 260.156 486.944 486.944 UP 1.0 0.0 0.0 GO:0045717 8 negative regulation of fatty acid biosynthetic process 10 10 4 4 3 3 2 2 67 8 2470 0.99801 0.028287 0.028287 20.0 64194;24207 insig1;apoc3 INSIG1_8906;APOC3_32553 20.264955 20.264955 2.87451 24.59380317470338 15.463953211796593 23.638018492576432 7.208235 7.208235 1.13737 8.585499618336138 5.532243746128033 8.251842844500816 54.651705 54.651705 8.23841 65.63831126342336 41.83832890229736 63.087421024097154 0.0 2.87451 0.0 2.87451 37.6554;2.87451 13.2791;1.13737 101.065;8.23841 1 1 1 64194 INSIG1_8906 37.6554 37.6554 13.2791 13.2791 101.065 101.065 37.6554 13.2791 101.065 1 24207 APOC3_32553 2.87451 2.87451 1.13737 1.13737 8.23841 8.23841 2.87451 1.13737 8.23841 0 Exp 4,1(0.5);Exp 5,1(0.5) 1.7309256053082143 3.490079641342163 1.5235437154769897 1.9665359258651733 0.31324279597830235 1.7450398206710815 -13.820317199999998 54.3502272 -4.690660399999995 19.107130399999996 -36.3183532 145.6217632 CONFLICT 0.5 0.5 0.0 GO:2000490 7 negative regulation of hepatic stellate cell activation 1 1 1 1 1 1 1 1 68 0 2478 1.0 0.027091 0.027091 100.0 25283 gclc GCLC_8699 145.958 145.958 145.958 145.958 96.7058 96.7058 96.7058 96.7058 280.185 280.185 280.185 280.185 0.0 145.958 0.0 145.958 145.958 96.7058 280.185 1 0 1 25283 GCLC_8699 145.958 145.958 96.7058 96.7058 280.185 280.185 145.958 96.7058 280.185 0 0 Poly 2,1(1) 1.7603585720062256 1.7603585720062256 1.7603585720062256 1.7603585720062256 0.0 1.7603585720062256 145.958 145.958 96.7058 96.7058 280.185 280.185 UP 1.0 0.0 0.0 GO:0032102 6 negative regulation of response to external stimulus 106 114 10 10 8 7 5 5 64 109 2369 0.91443 0.1938 0.23441 4.39 259241;288001;24426;24404;84586 nr1d2;kng1;gstp1;gpx1;fgl2 NR1D2_9358;KNG1L1_32433;GSTP1_8762;GPX1_33050;FGL2_32918 288001(0.1788) 58.052058 9.46041 3.87556 70.290074518326 21.46368064246307 43.93011445667759 37.326104 2.69961 1.25511 48.44819680862778 11.674702287773624 30.53714116193696 126.02968000000001 49.4216 13.8374 138.23974681325194 59.60758264815802 84.20979147789232 9.46041;3.87556;122.514;8.00432;146.406 2.2133;1.25511;84.8469;2.69961;95.6156 49.4216;13.8374;216.573;25.2254;325.091 3 2 3 259241;288001;24426 NR1D2_9358;KNG1L1_32433;GSTP1_8762 45.28332333333333 9.46041 66.94199504925166 29.43843666666667 2.2133 47.98752847084369 93.27733333333333 49.4216 108.24936436992753 9.46041;3.87556;122.514 2.2133;1.25511;84.8469 49.4216;13.8374;216.573 2 24404;84586 GPX1_33050;FGL2_32918 77.20516 77.20516 97.86476645561058 49.157605000000004 49.157605000000004 65.70152660966143 175.1582 175.1582 212.03699920457282 8.00432;146.406 2.69961;95.6156 25.2254;325.091 0 Exp 4,1(0.2);Hill,2(0.4);Poly 2,2(0.4) 2.2368283665682247 12.709425687789917 1.5755720138549805 5.5128583908081055 1.676742918008645 1.7846373319625854 -3.559908828469048 119.66402482846905 -5.140612888940979 79.79282088894098 4.8571993418178465 247.20216065818218 UP 0.6 0.4 0.0 GO:0009314 4 response to radiation 159 166 14 14 11 8 5 5 64 161 2317 0.70784 0.47167 0.80251 3.01 360243;25663;24404;25612;114628 top2a;il1r1;gpx1;asns;abcg5 TOP2A_10059;IL1R1_8893;GPX1_33050;ASNS_8091;ABCG5_7947 131.20904000000093 8.00432 4.48597E-12 244.7079414114199 205.68019511103614 288.7337424839254 83.9631820000009 2.7438 4.48597E-12 169.68858670960736 136.02852975848626 200.6405362132051 254.5287000000009 25.2254 4.48599E-12 449.82599255926675 390.61135765307944 529.4555115644317 4.48597E-12;76.6218;8.00432;6.05608;565.363 4.48597E-12;27.5215;2.69961;2.7438;386.851 4.48599E-12;185.143;25.2254;14.3351;1047.94 3 2 3 360243;25663;25612 TOP2A_10059;IL1R1_8893;ASNS_8091 27.559293333334825 6.05608 42.59713836109193 10.088433333334828 2.7438 15.159682373430124 66.49270000000149 14.3351 103.0038544937504 4.48597E-12;76.6218;6.05608 4.48597E-12;27.5215;2.7438 4.48599E-12;185.143;14.3351 2 24404;114628 GPX1_33050;ABCG5_7947 286.68366000000003 286.68366000000003 394.11210218118305 194.775305 194.775305 271.6360528712381 536.5827 536.5827 723.1684288784876 8.00432;565.363 2.69961;386.851 25.2254;1047.94 0 Hill,4(0.8);Linear,1(0.2) 2.0168685899467422 10.546780347824097 1.6931662559509277 3.5324413776397705 0.7963948919846756 1.783576488494873 -83.28692791894761 345.7050079189495 -64.77542223631048 232.70178623631227 -139.7611669842624 648.8185669842642 UP 0.6 0.4 0.0 GO:0010628 7 positive regulation of gene expression 455 488 22 22 20 16 14 14 55 474 2004 0.66347 0.4535 0.75822 2.87 360243;24614;259241;316351;24539;170496;64194;29200;25663;25317;24890;24309;25426;310395 top2a;orm1;nr1d2;npas2;lpl;lcn2;insig1;inhba;il1r1;fgf1;esr1;dbp;cyp1b1;noct TOP2A_10059;ORM1_9400;NR1D2_9358;NPAS2_9350;LPL_32544;LCN2_32481;INSIG1_8906;INHBA_33300;IL1R1_8893;FGF1_8633;ESR1_33192;DBP_8439;CYP1B1_32710;CCRN4L_8232 317.93660071428604 84.2161 4.48597E-12 367.1869231471678 277.4653571525267 339.62243745127046 189.55467928571463 35.84045 4.48597E-12 222.51624554730043 169.8071532032531 209.01267720925273 941.8181714285718 247.789 4.48599E-12 1315.4084850790057 766.9238315416277 1156.1004470857415 4.48597E-12;662.49;9.46041;53.0014;900.118;972.626;37.6554;91.8104;76.6218;674.162;12.5403;66.0377;229.313;665.276 4.48597E-12;432.445;2.2133;14.3825;487.466;551.931;13.2791;44.1594;27.5215;437.622;3.74981;19.9899;185.32;433.686 4.48599E-12;1413.32;49.4216;215.15;3428.38;4084.57;101.065;186.93;185.143;1465.0;51.2968;280.428;299.27;1425.48 10 4 10 360243;24614;259241;170496;64194;25663;25317;24309;25426;310395 TOP2A_10059;ORM1_9400;NR1D2_9358;LCN2_32481;INSIG1_8906;IL1R1_8893;FGF1_8633;DBP_8439;CYP1B1_32710;CCRN4L_8232 339.3642310000005 152.9674 364.32949679374354 210.40078000000048 106.42075 227.11474111310983 930.3697600000005 289.849 1265.7304342543773 4.48597E-12;662.49;9.46041;972.626;37.6554;76.6218;674.162;66.0377;229.313;665.276 4.48597E-12;432.445;2.2133;551.931;13.2791;27.5215;437.622;19.9899;185.32;433.686 4.48599E-12;1413.32;49.4216;4084.57;101.065;185.143;1465.0;280.428;299.27;1425.48 4 316351;24539;29200;24890 NPAS2_9350;LPL_32544;INHBA_33300;ESR1_33192 264.367525 72.4059 425.0675310660286 137.4394275 29.27095 233.97698335486984 970.4392 201.04000000000002 1640.1874049331152 53.0014;900.118;91.8104;12.5403 14.3825;487.466;44.1594;3.74981 215.15;3428.38;186.93;51.2968 0 Exp 2,1(0.08);Exp 4,1(0.08);Exp 5,1(0.08);Hill,6(0.43);Linear,5(0.36) 1.942847789156248 27.779682517051697 1.5487829446792603 3.1843981742858887 0.45744895777383116 1.8072510957717896 125.5923278494306 510.2808735791415 72.99354174961812 306.1158168218111 252.76506895363434 1630.871273903509 UP 0.7142857142857143 0.2857142857142857 0.0 GO:0016477 4 cell migration 189 200 8 8 7 4 3 3 66 197 2281 0.1958 0.91815 0.36554 1.5 94195;24404;25426 s100a9;gpx1;cyp1b1 S100A9_9775;GPX1_33050;CYP1B1_32710 400.21177333333327 229.313 8.00432 500.06084614166116 226.73434040156098 323.0405314161051 330.05420333333336 185.32 2.69961 418.91338682903654 184.2878156761495 270.31993061940204 494.39180000000005 299.27 25.2254 591.3833107145654 291.2053444827781 383.41975794281996 963.318;8.00432;229.313 802.143;2.69961;185.32 1158.68;25.2254;299.27 2 1 2 94195;25426 S100A9_9775;CYP1B1_32710 596.3154999999999 596.3154999999999 519.0199129248319 493.7315 493.7315 436.1597260918299 728.975 728.975 607.694638819531 963.318;229.313 802.143;185.32 1158.68;299.27 1 24404 GPX1_33050 8.00432 8.00432 2.69961 2.69961 25.2254 25.2254 8.00432 2.69961 25.2254 0 Hill,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 2.132164793094966 6.674666047096252 1.7056305408477783 3.1843981742858887 0.8318980508900566 1.7846373319625854 -165.6603443635837 966.0838910302504 -143.99091970631554 804.0993263729822 -174.82141472520044 1163.6050147252006 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0051129 6 negative regulation of cellular component organization 177 187 12 12 12 7 7 7 62 180 2298 0.87063 0.23995 0.34664 3.74 360243;192247;312538;64194;24404;25283;24207 top2a;sez6;mcm2;insig1;gpx1;gclc;apoc3 TOP2A_10059;SEZ6_9819;MCM2_9206;INSIG1_8906;GPX1_33050;GCLC_8699;APOC3_32553 29.842865714286354 8.00432 4.48597E-12 52.737111490222425 26.725227894005116 50.03565792531455 16.96265042857207 2.69961 4.48597E-12 35.448100172373024 15.02007176619435 33.46626580856023 66.73360142857207 25.2254 4.48599E-12 99.70287723036172 60.03951998832271 95.36834051021489 4.48597E-12;10.6392;3.76863;37.6554;8.00432;145.958;2.87451 4.48597E-12;3.96047;0.956203;13.2791;2.69961;96.7058;1.13737 4.48599E-12;29.4997;22.9217;101.065;25.2254;280.185;8.23841 4 3 4 360243;312538;64194;25283 TOP2A_10059;MCM2_9206;INSIG1_8906;GCLC_8699 46.84550750000112 20.712015 68.21012435483523 27.735275750001122 7.1176515 46.376281620791204 101.04292500000112 61.99335 127.0229401993548 4.48597E-12;3.76863;37.6554;145.958 4.48597E-12;0.956203;13.2791;96.7058 4.48599E-12;22.9217;101.065;280.185 3 192247;24404;24207 SEZ6_9819;GPX1_33050;APOC3_32553 7.172676666666668 8.00432 3.948585275061602 2.59915 2.69961 1.4142286099496082 20.987836666666666 25.2254 11.246258060752183 10.6392;8.00432;2.87451 3.96047;2.69961;1.13737 29.4997;25.2254;8.23841 0 Exp 4,1(0.15);Exp 5,1(0.15);Hill,4(0.58);Poly 2,1(0.15) 1.9151288477313024 14.063820362091064 1.5235437154769897 3.747737169265747 0.7820603307183699 1.7603585720062256 -9.225333208477977 68.91106463705069 -9.2976696730533 43.222970530197436 -7.127323653187531 140.59452651033166 CONFLICT 0.5714285714285714 0.42857142857142855 0.0 GO:0019433 8 triglyceride catabolic process 5 7 2 2 2 2 2 2 67 5 2473 0.99938 0.013912 0.013912 28.57 24539;24207 lpl;apoc3 LPL_32544;APOC3_32553 451.496255 451.496255 2.87451 634.4469561544843 244.55737439920188 562.9169917181995 244.301685 244.301685 1.13737 343.8862721581635 132.13558581067102 305.1152250611852 1718.309205 1718.309205 8.23841 2418.4053109071406 929.4929248943247 2145.7450921077166 0.0 2.87451 0.0 2.87451 900.118;2.87451 487.466;1.13737 3428.38;8.23841 0 2 0 2 24539;24207 LPL_32544;APOC3_32553 451.496255 451.496255 634.4469561544843 244.301685 244.301685 343.8862721581635 1718.309205 1718.309205 2418.4053109071406 900.118;2.87451 487.466;1.13737 3428.38;8.23841 0 Exp 2,1(0.5);Exp 4,1(0.5) 1.6110849987741636 3.2272000312805176 1.5235437154769897 1.7036563158035278 0.12735884106803746 1.6136000156402588 -427.80236520000005 1330.7948752000002 -232.30037240000004 720.9037424 -1633.4295531999996 5070.0479632 DOWN 0.0 1.0 0.0 GO:0010041 7 response to iron(III) ion 5 6 3 3 3 2 2 2 67 4 2474 0.99964 0.010113 0.010113 33.33 116686;24296 gsr;cyp1a1 GSR_8755;CYP1A1_8415 76.29560000000001 76.29560000000001 69.5519 9.53703200057533 77.67327238913629 9.33589936516162 52.06435 52.06435 41.1016 15.503669730905642 54.303933312425514 15.176702813800176 122.099 122.099 119.986 2.9882332572944037 121.66733462961801 2.925212473655767 0.0 69.5519 0.0 69.5519 69.5519;83.0393 41.1016;63.0271 124.212;119.986 2 0 2 116686;24296 GSR_8755;CYP1A1_8415 76.29560000000001 76.29560000000001 9.53703200057533 52.06435 52.06435 15.503669730905642 122.099 122.099 2.9882332572944037 69.5519;83.0393 41.1016;63.0271 124.212;119.986 0 0 Exp 4,1(0.5);Poly 2,1(0.5) 3.377216642390593 8.105029582977295 1.8125853538513184 6.292444229125977 3.1677385894654506 4.0525147914886475 63.07794800000001 89.513252 30.57736 73.55134 117.95752 126.24048 UP 1.0 0.0 0.0 GO:0010823 8 negative regulation of mitochondrion organization 22 22 3 3 3 2 2 2 67 20 2458 0.97973 0.1181 0.1181 9.09 24404;25283 gpx1;gclc GPX1_33050;GCLC_8699 76.98116 76.98116 8.00432 97.547982617639 70.72541374452554 97.14597361880436 49.702704999999995 49.702704999999995 2.69961 66.47241442251101 45.439833062956204 66.19847222447643 152.7052 152.7052 25.2254 180.2836620886097 141.1436195985401 179.54068768198803 0.5 76.98116 8.00432;145.958 2.69961;96.7058 25.2254;280.185 1 1 1 25283 GCLC_8699 145.958 145.958 96.7058 96.7058 280.185 280.185 145.958 96.7058 280.185 1 24404 GPX1_33050 8.00432 8.00432 2.69961 2.69961 25.2254 25.2254 8.00432 2.69961 25.2254 0 Hill,1(0.5);Poly 2,1(0.5) 1.7724563817602557 3.544995903968811 1.7603585720062256 1.7846373319625854 0.017167675803942465 1.7724979519844055 -58.21344640000001 212.1757664 -42.42336120000001 141.8287712 -97.15520799999999 402.565608 CONFLICT 0.5 0.5 0.0 GO:0002376 2 immune system process 352 390 13 13 9 9 5 5 64 385 2093 0.034754 0.98707 0.06194 1.28 94195;24614;170496;84586;117517 s100a9;orm1;lcn2;fgl2;c7 S100A9_9775;ORM1_9400;LCN2_32481;FGL2_32918;C7_8179 569.7396000000001 662.49 103.858 424.87676067867017 443.87607555650686 441.81659190496515 382.9732 432.445 32.7314 320.9132387239268 269.85617109375 311.0333488602551 1455.0884 1158.68 293.781 1551.5560757566254 1341.3469053403257 1685.1502552346062 963.318;662.49;972.626;146.406;103.858 802.143;432.445;551.931;95.6156;32.7314 1158.68;1413.32;4084.57;325.091;293.781 3 2 3 94195;24614;170496 S100A9_9775;ORM1_9400;LCN2_32481 866.1446666666667 963.318 176.4315084029303 595.5063333333334 551.931 188.66176098333597 2218.8566666666666 1413.32 1620.7637286271352 963.318;662.49;972.626 802.143;432.445;551.931 1158.68;1413.32;4084.57 2 84586;117517 FGL2_32918;C7_8179 125.132 125.132 30.08597932592525 64.1735 64.1735 44.4658442494911 309.43600000000004 309.43600000000004 22.139513318950105 146.406;103.858 95.6156;32.7314 325.091;293.781 0 Hill,1(0.2);Linear,2(0.4);Poly 2,2(0.4) 1.7348930551383626 8.701566934585571 1.5487829446792603 1.9308089017868042 0.15357692373271364 1.7056305408477783 197.31869897653286 942.1605010234671 101.6803438668033 664.2660561331968 95.08953633250576 2815.0872636674944 UP 0.6 0.4 0.0 GO:0051130 6 positive regulation of cellular component organization 262 280 11 11 10 4 4 4 65 276 2202 0.10848 0.95545 0.23799 1.43 192247;94195;170496;24890 sez6;s100a9;lcn2;esr1 SEZ6_9819;S100A9_9775;LCN2_32481;ESR1_33192 489.780875 487.92915 10.6392 552.1811703410598 350.75690137036133 528.9757217564494 340.44607 277.945735 3.74981 401.86102958356037 224.15343499818096 352.68568173452326 1331.011625 604.9884000000001 29.4997 1909.920176146093 1164.0159474836285 1976.71914629323 10.6392;963.318;972.626;12.5403 3.96047;802.143;551.931;3.74981 29.4997;1158.68;4084.57;51.2968 2 2 2 94195;170496 S100A9_9775;LCN2_32481 967.972 967.972 6.581749919279151 677.037 677.037 176.92660193424837 2621.625 2621.625 2068.916660005908 963.318;972.626 802.143;551.931 1158.68;4084.57 2 192247;24890 SEZ6_9819;ESR1_33192 11.58975 11.58975 1.34428070171374 3.85514 3.85514 0.14895911452475824 40.39825 40.39825 15.41287722020131 10.6392;12.5403 3.96047;3.74981 29.4997;51.2968 0 Hill,2(0.5);Linear,1(0.25);Poly 2,1(0.25) 2.1293364742438707 9.042220711708069 1.7056305408477783 3.747737169265747 0.9936518726300447 1.7944265007972717 -51.356671934238534 1030.9184219342387 -53.37773899188909 734.2698789918891 -540.710147623171 3202.733397623171 CONFLICT 0.5 0.5 0.0 GO:0051223 7 regulation of protein transport 189 204 8 8 7 5 4 4 65 200 2278 0.34032 0.81677 0.65392 1.96 361042;24614;24539;64194 pck2;orm1;lpl;insig1 PCK2_9440;ORM1_9400;LPL_32544;INSIG1_8906 401.7352575 350.0727 6.67763 449.0742572007484 236.36186475735434 414.79139372500174 233.6680125 222.86205 1.48195 262.30221093922177 132.9005881347199 238.41699910952866 1245.176875 757.1925 37.9425 1587.561527856709 778.1194090781338 1467.3765196761417 6.67763;662.49;900.118;37.6554 1.48195;432.445;487.466;13.2791 37.9425;1413.32;3428.38;101.065 3 1 3 361042;24614;64194 PCK2_9440;ORM1_9400;INSIG1_8906 235.60767666666666 37.6554 370.01526190062975 149.06868333333333 13.2791 245.48196639000966 517.4425 101.065 776.4943552636104 6.67763;662.49;37.6554 1.48195;432.445;13.2791 37.9425;1413.32;101.065 1 24539 LPL_32544 900.118 900.118 487.466 487.466 3428.38 3428.38 900.118 487.466 3428.38 0 Exp 2,1(0.25);Exp 5,1(0.25);Hill,1(0.25);Linear,1(0.25) 1.6782985222808733 6.747957348823547 1.528982162475586 1.9665359258651733 0.20206546596593752 1.626219630241394 -38.357514556733406 841.8280295567333 -23.388154220437258 490.72417922043724 -310.63342229957493 2800.987172299575 UP 0.75 0.25 0.0 GO:1901566 5 organonitrogen compound biosynthetic process 169 188 16 16 16 14 14 14 55 174 2304 0.9999 3.6315E-4 3.6315E-4 7.45 83472;287877;293820;58835;116682;29200;84029;24426;29739;25283;81508;25612;25748;296925 ugdh;pycr1;psat1;phgdh;kynu;inhba;hao2;gstp1;gclm;gclc;bhmt;asns;alas2;aass UGDH_10131;PYCR1_9631;PSAT1_9583;PHGDH_9470;KYNU_8979;INHBA_33300;HAO2_8778;GSTP1_8762;GCLM_8700;GCLC_8699;BHMT_8143;ASNS_8091;ALAS2_8019;AASS_7936 91.19163857142857 111.44749999999999 5.5396 60.273043110323066 91.45162147838474 63.24500605032916 53.41043571428571 68.45005 1.97501 37.471899960508196 53.471423741793615 38.41554808386368 189.48479999999998 201.75150000000002 14.0792 128.74060971004988 188.59832718784838 137.5255742386597 8.5 124.166 59.3662;132.668;27.1579;122.826;100.381;91.8104;140.856;122.514;190.233;145.958;5.5396;6.05608;125.506;5.81076 25.4417;90.3184;10.0144;67.6778;72.7231;44.1594;93.5219;84.8469;69.2223;96.7058;1.97501;2.7438;85.7907;2.60489 135.068;239.858;103.876;246.456;161.456;186.93;282.925;216.573;496.452;280.185;37.8319;14.3351;236.762;14.0792 8 6 8 83472;287877;293820;58835;24426;29739;25283;25612 UGDH_10131;PYCR1_9631;PSAT1_9583;PHGDH_9470;GSTP1_8762;GCLM_8700;GCLC_8699;ASNS_8091 100.8473975 122.66999999999999 63.38772912867551 55.871387500000004 68.45005 37.53595270295389 216.6003875 228.21550000000002 143.4561989542496 59.3662;132.668;27.1579;122.826;122.514;190.233;145.958;6.05608 25.4417;90.3184;10.0144;67.6778;84.8469;69.2223;96.7058;2.7438 135.068;239.858;103.876;246.456;216.573;496.452;280.185;14.3351 6 116682;29200;84029;81508;25748;296925 KYNU_8979;INHBA_33300;HAO2_8778;BHMT_8143;ALAS2_8019;AASS_7936 78.31729333333334 96.0957 58.92457037729053 50.12916666666667 58.44125 40.68950203754165 153.33068333333333 174.19299999999998 107.4070304276665 100.381;91.8104;140.856;5.5396;125.506;5.81076 72.7231;44.1594;93.5219;1.97501;85.7907;2.60489 161.456;186.93;282.925;37.8319;236.762;14.0792 0 Exp 4,2(0.15);Hill,6(0.43);Poly 2,6(0.43) 2.168761727015805 32.37235105037689 1.5737498998641968 5.5128583908081055 1.0449005836331782 1.933137059211731 59.61868779463675 122.7645893482204 33.78145413456917 73.03941729400228 122.04634453808555 256.92325546191444 CONFLICT 0.5714285714285714 0.42857142857142855 0.0 GO:0006954 5 inflammatory response 129 140 10 10 7 8 5 5 64 135 2343 0.82436 0.32879 0.42703 3.57 94195;24614;288001;25663;24207 s100a9;orm1;kng1;il1r1;apoc3 S100A9_9775;ORM1_9400;KNG1L1_32433;IL1R1_8893;APOC3_32553 288001(0.1788) 341.83597399999996 76.6218 2.87451 443.990311445433 155.9358943482061 336.40221718043614 252.900396 27.5215 1.13737 357.5644420461488 109.80256283878862 263.1076868232158 555.8437620000001 185.143 8.23841 676.33915336825 270.90481098064066 538.3241725348018 963.318;662.49;3.87556;76.6218;2.87451 802.143;432.445;1.25511;27.5215;1.13737 1158.68;1413.32;13.8374;185.143;8.23841 4 1 4 94195;24614;288001;25663 S100A9_9775;ORM1_9400;KNG1L1_32433;IL1R1_8893 426.57633999999996 369.5559 463.641741733626 315.8411525 229.98325 379.55172870429186 692.7451 671.9115 696.3952600335818 963.318;662.49;3.87556;76.6218 802.143;432.445;1.25511;27.5215 1158.68;1413.32;13.8374;185.143 1 24207 APOC3_32553 2.87451 2.87451 1.13737 1.13737 8.23841 8.23841 2.87451 1.13737 8.23841 0 Exp 4,2(0.4);Hill,1(0.2);Linear,1(0.2);Poly 2,1(0.2) 1.6075839471648983 8.046695470809937 1.5235437154769897 1.7056305408477783 0.08436104805354201 1.5755720138549805 -47.33869295537016 731.01064095537 -60.518656310773366 566.3194483107733 -36.99364452821658 1148.6811685282164 UP 0.8 0.2 0.0 GO:0035556 5 intracellular signal transduction 318 334 16 16 13 7 4 4 65 330 2148 0.040557 0.98594 0.070716 1.2 171497;24567;24404;25426 sgk2;mt1;gpx1;cyp1b1 SGK2_32380;MT1A_9255;GPX1_33050;CYP1B1_32710 303.00532999999996 192.8415 8.00432 355.6785597183815 188.3724144617656 209.04247785618333 207.21290249999998 142.968 2.69961 234.20713663781618 137.7171504177342 144.16064230807277 414.04885 321.23749999999995 25.2254 407.98900720888304 279.63452541578005 251.75918561279542 156.37;818.334;8.00432;229.313 100.616;540.216;2.69961;185.32 343.205;988.495;25.2254;299.27 2 2 2 171497;25426 SGK2_32380;CYP1B1_32710 192.8415 192.8415 51.578489940090414 142.968 142.968 59.89477279362537 321.23749999999995 321.23749999999995 31.06673643143152 156.37;229.313 100.616;185.32 343.205;299.27 2 24567;24404 MT1A_9255;GPX1_33050 413.16916 413.16916 572.9896117247251 271.457805 271.457805 380.08148436791294 506.8602 506.8602 681.1344662708532 818.334;8.00432 540.216;2.69961 988.495;25.2254 0 Hill,1(0.25);Linear,1(0.25);Poly 2,2(0.5) 2.241264567492873 9.205993056297302 1.7846373319625854 3.1843981742858887 0.6349029057470779 2.118478775024414 -45.559658524013855 651.5703185240138 -22.310091405059865 436.73589640505986 14.219622935294638 813.8780770647053 CONFLICT 0.5 0.5 0.0 GO:0045892 8 negative regulation of transcription, DNA-templated 221 232 10 10 6 6 3 3 66 229 2249 0.11239 0.95871 0.20415 1.29 259241;25283;24890 nr1d2;gclc;esr1 NR1D2_9358;GCLC_8699;ESR1_33192 55.98623666666666 12.5403 9.46041 77.93304869299695 42.57006345395203 70.33662556670944 34.22297 3.74981 2.2133 54.11717148328893 24.95280554846034 48.8086074641406 126.96780000000001 51.2968 49.4216 132.69330004050693 104.3835960361383 119.57331773451858 9.46041;145.958;12.5403 2.2133;96.7058;3.74981 49.4216;280.185;51.2968 2 1 2 259241;25283 NR1D2_9358;GCLC_8699 77.709205 77.709205 96.51837150462109 49.45955 49.45955 66.81628752126984 164.8033 164.8033 163.17436498966373 9.46041;145.958 2.2133;96.7058 49.4216;280.185 1 24890 ESR1_33192 12.5403 12.5403 3.74981 3.74981 51.2968 51.2968 12.5403 3.74981 51.2968 0 Hill,2(0.67);Poly 2,1(0.34) 1.8792789302797337 5.669224977493286 1.7318620681762695 2.177004337310791 0.24918446455286508 1.7603585720062256 -32.20330995100653 144.17578328433987 -27.016374506369687 95.46231450636968 -23.18880449617106 277.124404496171 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0032496 5 response to lipopolysaccharide 176 189 15 15 10 12 7 7 62 182 2296 0.86478 0.24831 0.35079 3.7 94195;361042;24614;170496;24426;24296;310395 s100a9;pck2;orm1;lcn2;gstp1;cyp1a1;noct S100A9_9775;PCK2_9440;ORM1_9400;LCN2_32481;GSTP1_8762;CYP1A1_8415;CCRN4L_8232 496.56298999999996 662.49 6.67763 418.6076596477754 352.24367015199635 407.1433818926941 338.50870714285713 432.445 1.48195 297.8282615032032 230.52954986104808 267.3977977621622 1208.0787857142857 1158.68 37.9425 1408.443452330795 931.0541639916062 1382.3260919378201 963.318;6.67763;662.49;972.626;122.514;83.0393;665.276 802.143;1.48195;432.445;551.931;84.8469;63.0271;433.686 1158.68;37.9425;1413.32;4084.57;216.573;119.986;1425.48 7 0 7 94195;361042;24614;170496;24426;24296;310395 S100A9_9775;PCK2_9440;ORM1_9400;LCN2_32481;GSTP1_8762;CYP1A1_8415;CCRN4L_8232 496.56298999999996 662.49 418.6076596477754 338.50870714285713 432.445 297.8282615032032 1208.0787857142857 1158.68 1408.443452330795 963.318;6.67763;662.49;972.626;122.514;83.0393;665.276 802.143;1.48195;432.445;551.931;84.8469;63.0271;433.686 1158.68;37.9425;1413.32;4084.57;216.573;119.986;1425.48 0 0 Hill,1(0.15);Linear,3(0.43);Poly 2,3(0.43) 2.398976575082779 20.203200459480286 1.528982162475586 6.292444229125977 2.0760343811289794 1.7575112581253052 186.45409598626122 806.6718840137388 117.87444340648469 559.1429708792296 164.6892747562149 2251.4682966723567 UP 1.0 0.0 0.0 GO:0006575 4 cellular modified amino acid metabolic process 61 71 14 14 12 12 10 10 59 61 2417 1.0 1.3618E-5 1.3618E-5 14.08 293656;680308;84029;24426;300850;116686;24404;29739;25283;81508 rgd1307603;mthfd2;hao2;gstp1;gsta4;gsr;gpx1;gclm;gclc;bhmt RGD1307603_9684;MTHFD2_9261;HAO2_8778;GSTP1_8762;GSTA4_8757;GSR_8755;GPX1_33050;GCLM_8700;GCLC_8699;BHMT_8143 167.67503200000002 131.685 5.5396 188.5662940211014 146.92495953928503 165.4942459206981 107.688432 77.03460000000001 1.97501 131.34880719917567 93.61042990085595 117.40163181053252 327.92143999999996 248.37900000000002 25.2254 365.2402368457482 284.98115613270403 310.8513152694503 2.5 50.7837 6.5 168.09550000000002 32.0155;622.58;140.856;122.514;339.498;69.5519;8.00432;190.233;145.958;5.5396 12.3892;414.266;93.5219;84.8469;260.156;41.1016;2.69961;69.2223;96.7058;1.97501 78.5761;1250.29;282.925;216.573;486.944;124.212;25.2254;496.452;280.185;37.8319 6 4 6 680308;24426;300850;116686;29739;25283 MTHFD2_9261;GSTP1_8762;GSTA4_8757;GSR_8755;GCLM_8700;GCLC_8699 248.38915000000006 168.09550000000002 204.94936370736795 161.04976666666667 90.77635000000001 146.08721748652297 475.776 383.5645 407.2992604908583 622.58;122.514;339.498;69.5519;190.233;145.958 414.266;84.8469;260.156;41.1016;69.2223;96.7058 1250.29;216.573;486.944;124.212;496.452;280.185 4 293656;84029;24404;81508 RGD1307603_9684;HAO2_8778;GPX1_33050;BHMT_8143 46.603854999999996 20.00991 63.959581194241466 27.646430000000002 7.544405 44.172865909298515 106.1396 58.20399999999999 120.03593049074932 32.0155;140.856;8.00432;5.5396 12.3892;93.5219;2.69961;1.97501 78.5761;282.925;25.2254;37.8319 0 Exp 4,3(0.3);Hill,2(0.2);Linear,2(0.2);Poly 2,3(0.3) 1.9725791960754366 21.420233607292175 1.5278362035751343 5.5128583908081055 1.1962483474283323 1.7724979519844055 50.80043210744044 284.54963189255955 26.2775978556395 189.09926614436046 101.54319585190416 554.2996841480958 UP 0.6 0.4 0.0 GO:0010038 5 response to metal ion 201 215 15 15 10 11 7 7 62 208 2270 0.77729 0.36355 0.51552 3.26 94195;24567;300850;116686;25283;24296;25748 s100a9;mt1;gsta4;gsr;gclc;cyp1a1;alas2 S100A9_9775;MT1A_9255;GSTA4_8757;GSR_8755;GCLC_8699;CYP1A1_8415;ALAS2_8019 363.6007428571429 145.958 69.5519 373.3320642489375 215.37630865363903 261.32120552544825 269.87717142857144 96.7058 41.1016 293.11143007682654 159.02374019079855 206.26048410412483 485.0377142857143 280.185 119.986 423.1489526186235 310.2784014156024 307.640633026056 963.318;818.334;339.498;69.5519;145.958;83.0393;125.506 802.143;540.216;260.156;41.1016;96.7058;63.0271;85.7907 1158.68;988.495;486.944;124.212;280.185;119.986;236.762 5 2 5 94195;300850;116686;25283;24296 S100A9_9775;GSTA4_8757;GSR_8755;GCLC_8699;CYP1A1_8415 320.27304 145.958 375.30090936337075 252.62669999999997 96.7058 318.99336107165306 434.0014 280.185 431.913365413482 963.318;339.498;69.5519;145.958;83.0393 802.143;260.156;41.1016;96.7058;63.0271 1158.68;486.944;124.212;280.185;119.986 2 24567;25748 MT1A_9255;ALAS2_8019 471.91999999999996 471.91999999999996 489.90337699591333 313.00335 313.00335 321.32721117273115 612.6285 612.6285 531.5555019417069 818.334;125.506 540.216;85.7907 988.495;236.762 0 Exp 4,1(0.15);Linear,1(0.15);Poly 2,5(0.72) 2.196557732176106 17.41960871219635 1.7056305408477783 6.292444229125977 1.6914890824882383 1.7603585720062256 87.03247929140144 640.1690064228842 52.73718531271277 487.01715754443 171.56458335914147 798.5108452122871 UP 0.7142857142857143 0.2857142857142857 0.0 GO:1904469 7 positive regulation of tumor necrosis factor secretion 9 9 2 2 2 2 2 2 67 7 2471 0.99858 0.023028 0.023028 22.22 24614;24539 orm1;lpl ORM1_9400;LPL_32544 781.3040000000001 781.3040000000001 662.49 168.02837019979657 809.520056017654 163.2214494409894 459.95550000000003 459.95550000000003 432.445 38.905722207664525 466.48871838397554 37.792715377366505 2420.85 2420.85 1413.32 1424.8625904977648 2660.1191342726192 1384.1004170828287 0.0 662.49 0.0 662.49 662.49;900.118 432.445;487.466 1413.32;3428.38 1 1 1 24614 ORM1_9400 662.49 662.49 432.445 432.445 1413.32 1413.32 662.49 432.445 1413.32 1 24539 LPL_32544 900.118 900.118 487.466 487.466 3428.38 3428.38 900.118 487.466 3428.38 0 Exp 2,1(0.5);Linear,1(0.5) 1.6243749091609387 3.252439260482788 1.5487829446792603 1.7036563158035278 0.10951201094719044 1.626219630241394 548.4285600000001 1014.1794400000001 406.03492 513.87608 446.09119999999984 4395.6088 CONFLICT 0.5 0.5 0.0 GO:0007610 2 behavior 142 151 7 7 6 4 3 3 66 148 2330 0.40679 0.78772 0.79623 1.99 192247;259241;316351 sez6;nr1d2;npas2 SEZ6_9819;NR1D2_9358;NPAS2_9350 24.367003333333333 10.6392 9.46041 24.80511823825948 13.836405516344966 15.378609968195189 6.85209 3.96047 2.2133 6.579776350933216 3.8258028914018327 4.2462542647548425 98.02376666666667 49.4216 29.4997 101.92220771766736 59.37241546110353 62.04199856878393 10.6392;9.46041;53.0014 3.96047;2.2133;14.3825 29.4997;49.4216;215.15 1 2 1 259241 NR1D2_9358 9.46041 9.46041 2.2133 2.2133 49.4216 49.4216 9.46041 2.2133 49.4216 2 192247;316351 SEZ6_9819;NPAS2_9350 31.8203 31.8203 29.954598885980758 9.171485 9.171485 7.369488086729634 122.32485 122.32485 131.2745860593169 10.6392;53.0014 3.96047;14.3825 29.4997;215.15 0 Hill,3(1) 2.7828011822724212 8.566043853759766 2.177004337310791 3.747737169265747 0.8069461244789433 2.6413023471832275 -3.7026303832603062 52.436637049926965 -0.5936278689408976 14.297807868940899 -17.312068895237914 213.35960222857125 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0009628 3 response to abiotic stimulus 422 443 28 28 24 15 12 12 57 431 2047 0.57647 0.55107 1.0 2.71 360243;59107;24539;25663;116686;24404;25283;25317;24296;25612;25748;114628 top2a;ltbp1;lpl;il1r1;gsr;gpx1;gclc;fgf1;cyp1a1;asns;alas2;abcg5 TOP2A_10059;LTBP1_33264;LPL_32544;IL1R1_8893;GSR_8755;GPX1_33050;GCLC_8699;FGF1_8633;CYP1A1_8415;ASNS_8091;ALAS2_8019;ABCG5_7947 285.3145333333337 104.27265 4.48597E-12 337.6680458965248 274.68447124203135 312.7716377908548 172.46300916666704 74.4089 4.48597E-12 199.29002454442204 173.82922479495446 194.0300722993181 761.5307083333337 210.9525 4.48599E-12 1092.4515698663986 650.7359005681907 921.0493581981539 4.48597E-12;769.394;900.118;76.6218;69.5519;8.00432;145.958;674.162;83.0393;6.05608;125.506;565.363 4.48597E-12;438.027;487.466;27.5215;41.1016;2.69961;96.7058;437.622;63.0271;2.7438;85.7907;386.851 4.48599E-12;2211.2;3428.38;185.143;124.212;25.2254;280.185;1465.0;119.986;14.3351;236.762;1047.94 7 5 7 360243;25663;116686;25283;25317;24296;25612 TOP2A_10059;IL1R1_8893;GSR_8755;GCLC_8699;FGF1_8633;CYP1A1_8415;ASNS_8091 150.7698685714292 76.6218 236.05007788002112 95.53168571428635 41.1016 154.6003579488136 312.69444285714354 124.212 517.1383790872346 4.48597E-12;76.6218;69.5519;145.958;674.162;83.0393;6.05608 4.48597E-12;27.5215;41.1016;96.7058;437.622;63.0271;2.7438 4.48599E-12;185.143;124.212;280.185;1465.0;119.986;14.3351 5 59107;24539;24404;25748;114628 LTBP1_33264;LPL_32544;GPX1_33050;ALAS2_8019;ABCG5_7947 473.677064 565.363 392.358536069168 280.16686200000004 386.851 220.25237193501846 1389.90148 1047.94 1426.4409427766548 769.394;900.118;8.00432;125.506;565.363 438.027;487.466;2.69961;85.7907;386.851 2211.2;3428.38;25.2254;236.762;1047.94 0 Exp 2,2(0.17);Exp 4,1(0.09);Hill,4(0.34);Linear,2(0.17);Poly 2,3(0.25) 2.0256668729423914 26.958913683891296 1.5140434503555298 6.292444229125977 1.3801047870765553 1.7594949007034302 94.26085088214214 476.36821578452543 59.70406283548846 285.2219554978456 143.41804455311933 1379.6433721135481 CONFLICT 0.5833333333333334 0.4166666666666667 0.0 GO:0098609 4 cell-cell adhesion 84 86 5 5 3 3 2 2 67 84 2394 0.58558 0.68522 1.0 2.33 94195;25426 s100a9;cyp1b1 S100A9_9775;CYP1B1_32710 596.3154999999999 596.3154999999999 229.313 519.0199129248319 338.43541114149014 369.2930943751237 493.7315 493.7315 185.32 436.1597260918299 277.0213004101162 310.3364069069652 728.975 728.975 299.27 607.694638819531 427.03601161995897 432.3869431910207 963.318;229.313 802.143;185.32 1158.68;299.27 2 0 2 94195;25426 S100A9_9775;CYP1B1_32710 596.3154999999999 596.3154999999999 519.0199129248319 493.7315 493.7315 436.1597260918299 728.975 728.975 607.694638819531 963.318;229.313 802.143;185.32 1158.68;299.27 0 0 Linear,1(0.5);Poly 2,1(0.5) 2.330537873599551 4.890028715133667 1.7056305408477783 3.1843981742858887 1.0456466214032707 2.4450143575668335 -123.00940000000003 1315.6403999999998 -110.75504000000012 1098.2180400000002 -113.2467999999999 1571.1968 UP 1.0 0.0 0.0 GO:0060429 5 epithelium development 39 42 2 2 2 2 2 2 67 40 2438 0.89671 0.3158 0.3158 4.76 58835;25317 phgdh;fgf1 PHGDH_9470;FGF1_8633 398.494 398.494 122.826 389.8534243122663 447.7418329709874 383.5817961573822 252.6499 252.6499 67.6778 261.5900524806324 285.6949944073769 257.3818156514463 855.728 855.728 246.456 861.6407255741805 964.5738787015521 847.7793871918412 122.826;674.162 67.6778;437.622 246.456;1465.0 2 0 2 58835;25317 PHGDH_9470;FGF1_8633 398.494 398.494 389.8534243122663 252.6499 252.6499 261.5900524806324 855.728 855.728 861.6407255741805 122.826;674.162 67.6778;437.622 246.456;1465.0 0 0 Exp 4,1(0.5);Linear,1(0.5) 1.6802844058491762 3.368255615234375 1.5704141855239868 1.7978414297103882 0.16081534659077323 1.6841278076171875 -141.81527999999992 938.80328 -109.89541599999995 615.195216 -338.44511999999986 2049.90112 UP 1.0 0.0 0.0 GO:0015698 7 inorganic anion transport 24 26 2 2 2 2 2 2 67 24 2454 0.96831 0.15528 0.15528 7.69 266730;301111 slc17a3;ano10 SLC17A3_9840;ANO10_8049 51.6523 51.6523 9.9207 59.01739469952906 61.391068572383816 57.387852813179 35.92085 35.92085 2.9165 46.67519938730846 43.6229684553661 45.38644049101029 88.30315 88.30315 33.1883 77.94416835815879 101.16512435640253 75.79203528310539 0.5 51.6523 93.3839;9.9207 68.9252;2.9165 143.418;33.1883 2 0 2 266730;301111 SLC17A3_9840;ANO10_8049 51.6523 51.6523 59.01739469952906 35.92085 35.92085 46.67519938730846 88.30315 88.30315 77.94416835815879 93.3839;9.9207 68.9252;2.9165 143.418;33.1883 0 0 Hill,1(0.5);Poly 2,1(0.5) 1.5393716914665674 3.079559087753296 1.504341721534729 1.575217366218567 0.05011664897691005 1.539779543876648 -30.141636000000005 133.446236 -28.76767600000001 100.60937600000001 -19.721956000000006 196.328256 UP 1.0 0.0 0.0 GO:0071396 6 cellular response to lipid 195 209 22 22 19 14 11 11 58 198 2280 0.99099 0.022729 0.025228 5.26 361042;24614;59107;24539;170496;64194;29200;24426;24890;25315;25426 pck2;orm1;ltbp1;lpl;lcn2;insig1;inhba;gstp1;esr1;ephx1;cyp1b1 PCK2_9440;ORM1_9400;LTBP1_33264;LPL_32544;LCN2_32481;INSIG1_8906;INHBA_33300;GSTP1_8762;ESR1_33192;EPHX1_8567;CYP1B1_32710 348.4281390909091 122.514 6.67763 391.15894949030303 230.43147600191358 343.74072749052044 205.03058727272727 84.8469 1.48195 224.17827045753452 138.67927415254235 198.200775249848 1099.321190909091 216.573 37.9425 1490.648820945179 717.5043014591306 1335.409075265666 9.5 936.3720000000001 6.67763;662.49;769.394;900.118;972.626;37.6554;91.8104;122.514;12.5403;27.5708;229.313 1.48195;432.445;438.027;487.466;551.931;13.2791;44.1594;84.8469;3.74981;12.6303;185.32 37.9425;1413.32;2211.2;3428.38;4084.57;101.065;186.93;216.573;51.2968;61.9858;299.27 7 4 7 361042;24614;170496;64194;24426;25315;25426 PCK2_9440;ORM1_9400;LCN2_32481;INSIG1_8906;GSTP1_8762;EPHX1_8567;CYP1B1_32710 294.1209757142857 122.514 376.2005446033965 183.1334642857143 84.8469 223.14121111503349 887.8180428571429 216.573 1489.7204307577913 6.67763;662.49;972.626;37.6554;122.514;27.5708;229.313 1.48195;432.445;551.931;13.2791;84.8469;12.6303;185.32 37.9425;1413.32;4084.57;101.065;216.573;61.9858;299.27 4 59107;24539;29200;24890 LTBP1_33264;LPL_32544;INHBA_33300;ESR1_33192 443.46567500000003 430.6022 456.1135568472057 243.3505525 241.0932 254.674237644993 1469.4517 1199.0649999999998 1637.4386356398907 769.394;900.118;91.8104;12.5403 438.027;487.466;44.1594;3.74981 2211.2;3428.38;186.93;51.2968 0 Exp 2,2(0.19);Exp 5,1(0.1);Hill,4(0.37);Linear,3(0.28);Poly 2,1(0.1) 2.1612402927732197 25.931491017341614 1.5140434503555298 5.5128583908081055 1.2023441412756195 1.856990933418274 117.2679719141934 579.5883062676248 72.5496954412205 337.5114791042341 218.4040315280705 1980.2383502901116 UP 0.6363636363636364 0.36363636363636365 0.0 GO:0010996 5 response to auditory stimulus 12 13 3 3 2 3 2 2 67 11 2467 0.99552 0.046539 0.046539 15.38 116686;25283 gsr;gclc GSR_8755;GCLC_8699 107.75495000000001 107.75495000000001 69.5519 54.02727143401748 103.1676157248808 53.63635695217967 68.9037 68.9037 41.1016 39.31810688245302 65.56528785096238 39.033620604119186 202.1985 202.1985 124.212 110.28956598200936 192.83406065689562 109.49156550199959 0.0 69.5519 0.5 107.75495000000001 69.5519;145.958 41.1016;96.7058 124.212;280.185 2 0 2 116686;25283 GSR_8755;GCLC_8699 107.75495000000001 107.75495000000001 54.02727143401748 68.9037 68.9037 39.31810688245302 202.1985 202.1985 110.28956598200936 69.5519;145.958 41.1016;96.7058 124.212;280.185 0 0 Exp 4,1(0.5);Poly 2,1(0.5) 1.7862810991400837 3.572943925857544 1.7603585720062256 1.8125853538513184 0.03692991160221557 1.786471962928772 32.87697200000002 182.632928 14.411584000000012 123.395816 49.344960000000015 355.05204000000003 UP 1.0 0.0 0.0 GO:0072330 7 monocarboxylic acid biosynthetic process 51 55 6 6 5 5 4 4 65 51 2427 0.98464 0.059759 0.059759 7.27 24539;24426;24296;25612 lpl;gstp1;cyp1a1;asns LPL_32544;GSTP1_8762;CYP1A1_8415;ASNS_8091 277.931845 102.77664999999999 6.05608 417.600228970659 237.09478655843435 387.81142213249717 159.52095 73.937 2.7438 221.37020833349882 139.32878795174022 204.63579388213938 944.818525 168.2795 14.3351 1657.7662926645507 777.82171065273 1544.124197346683 1.5 102.77664999999999 900.118;122.514;83.0393;6.05608 487.466;84.8469;63.0271;2.7438 3428.38;216.573;119.986;14.3351 3 1 3 24426;24296;25612 GSTP1_8762;CYP1A1_8415;ASNS_8091 70.53645999999999 83.0393 59.22712671344779 50.20593333333333 63.0271 42.52665626901949 116.9647 119.986 101.15279649802078 122.514;83.0393;6.05608 84.8469;63.0271;2.7438 216.573;119.986;14.3351 1 24539 LPL_32544 900.118 900.118 487.466 487.466 3428.38 3428.38 900.118 487.466 3428.38 0 Exp 2,1(0.25);Hill,1(0.25);Poly 2,2(0.5) 3.8011349697349344 17.04140031337738 1.7036563158035278 6.292444229125977 2.062742331816901 4.522649884223938 -131.31637939124573 687.1800693912458 -57.42185416682884 376.46375416682883 -679.7924418112598 2569.4294918112596 UP 0.75 0.25 0.0 GO:0034645 5 cellular macromolecule biosynthetic process 143 162 8 8 8 6 6 6 63 156 2322 0.85453 0.27305 0.44642 3.7 83472;29685;29200;499709;24890;25748 ugdh;mcm6;inhba;gar1;esr1;alas2 UGDH_10131;MCM6_9210;INHBA_33300;GAR1_8683;ESR1_33192;ALAS2_8019 499709(-0.07184) 176.07688500000003 75.5883 1.87441 292.44816967514737 87.75623319830495 199.6687331529605 124.44541116666666 34.80055 0.496857 228.76216463786582 57.80670179444084 154.3863620652101 330.29946666666666 160.99900000000002 9.53 512.4440017751273 173.85335243841126 351.23796858327853 59.3662;1.87441;91.8104;765.364;12.5403;125.506 25.4417;0.496857;44.1594;587.034;3.74981;85.7907 135.068;9.53;186.93;1362.21;51.2968;236.762 3 3 3 83472;29685;499709 UGDH_10131;MCM6_9210;GAR1_8683 275.53487 59.3662 425.17732644952827 204.32418566666664 25.4417 331.6710159003414 502.26933333333335 135.068 747.3709989030438 59.3662;1.87441;765.364 25.4417;0.496857;587.034 135.068;9.53;1362.21 3 29200;24890;25748 INHBA_33300;ESR1_33192;ALAS2_8019 76.6189 91.8104 57.99481527093608 44.56663666666666 44.1594 41.02196106081513 158.3296 186.93 95.98344785888871 91.8104;12.5403;125.506 44.1594;3.74981;85.7907 186.93;51.2968;236.762 0 Exp 2,1(0.17);Hill,4(0.67);Poly 2,1(0.17) 1.7856430204270533 10.797796368598938 1.5737498998641968 2.2924909591674805 0.258061760370795 1.7452466487884521 -57.93038702556268 410.0841570255627 -58.60244360032752 307.49326593366084 -79.74113319232015 740.3400665256534 CONFLICT 0.5 0.5 0.0 GO:0019878 10 lysine biosynthetic process via aminoadipic acid 1 1 1 1 1 1 1 1 68 0 2478 1.0 0.027091 0.027091 100.0 296925 aass AASS_7936 5.81076 5.81076 5.81076 5.81076 2.60489 2.60489 2.60489 2.60489 14.0792 14.0792 14.0792 14.0792 0.0 5.81076 0.0 5.81076 5.81076 2.60489 14.0792 0 1 0 1 296925 AASS_7936 5.81076 5.81076 2.60489 2.60489 14.0792 14.0792 5.81076 2.60489 14.0792 0 Hill,1(1) 2.3450815677642822 2.3450815677642822 2.3450815677642822 2.3450815677642822 0.0 2.3450815677642822 5.81076 5.81076 2.60489 2.60489 14.0792 14.0792 DOWN 0.0 1.0 0.0 GO:0033512 10 L-lysine catabolic process to acetyl-CoA via saccharopine 1 1 1 1 1 1 1 1 68 0 2478 1.0 0.027091 0.027091 100.0 296925 aass AASS_7936 5.81076 5.81076 5.81076 5.81076 2.60489 2.60489 2.60489 2.60489 14.0792 14.0792 14.0792 14.0792 0.0 5.81076 0.0 5.81076 5.81076 2.60489 14.0792 0 1 0 1 296925 AASS_7936 5.81076 5.81076 2.60489 2.60489 14.0792 14.0792 5.81076 2.60489 14.0792 0 Hill,1(1) 2.3450815677642822 2.3450815677642822 2.3450815677642822 2.3450815677642822 0.0 2.3450815677642822 5.81076 5.81076 2.60489 2.60489 14.0792 14.0792 DOWN 0.0 1.0 0.0 GO:0009636 4 response to toxic substance 240 257 24 24 21 14 12 12 57 245 2233 0.98189 0.040205 0.063724 4.67 94195;170496;360504;24426;300850;116686;24404;25315;25426;24296;54232;25612 s100a9;lcn2;hba-a2;gstp1;gsta4;gsr;gpx1;ephx1;cyp1b1;cyp1a1;car3;asns S100A9_9775;LCN2_32481;HBA2_32600;GSTP1_8762;GSTA4_8757;GSR_8755;GPX1_33050;EPHX1_8567;CYP1B1_32710;CYP1A1_8415;CAR3_8196;ASNS_8091 246.33256083333333 102.77664999999999 3.44933 351.42037112013185 185.89371923785185 274.9989050149012 174.7771283333333 73.937 2.13143 253.05587032633176 129.51917442956065 185.13293310964792 570.9971191666667 170.3925 6.02113 1151.5414240178525 436.4782655355144 1002.7074650925954 963.318;972.626;131.05;122.514;339.498;69.5519;8.00432;27.5708;229.313;83.0393;3.44933;6.05608 802.143;551.931;88.5948;84.8469;260.156;41.1016;2.69961;12.6303;185.32;63.0271;2.13143;2.7438 1158.68;4084.57;254.163;216.573;486.944;124.212;25.2254;61.9858;299.27;119.986;6.02113;14.3351 9 3 9 94195;170496;24426;300850;116686;25315;25426;24296;25612 S100A9_9775;LCN2_32481;GSTP1_8762;GSTA4_8757;GSR_8755;EPHX1_8567;CYP1B1_32710;CYP1A1_8415;ASNS_8091 312.60967555555555 122.514 385.655685678002 222.6555222222222 84.8469 277.699104242041 729.6173222222222 216.573 1305.8824768771365 963.318;972.626;122.514;339.498;69.5519;27.5708;229.313;83.0393;6.05608 802.143;551.931;84.8469;260.156;41.1016;12.6303;185.32;63.0271;2.7438 1158.68;4084.57;216.573;486.944;124.212;61.9858;299.27;119.986;14.3351 3 360504;24404;54232 HBA2_32600;GPX1_33050;CAR3_8196 47.50121666666667 8.00432 72.39120375318561 31.14194666666667 2.69961 49.756441535084015 95.13651 25.2254 138.05531278385595 131.05;8.00432;3.44933 88.5948;2.69961;2.13143 254.163;25.2254;6.02113 0 Exp 4,2(0.17);Hill,3(0.25);Linear,3(0.25);Poly 2,4(0.34) 2.848361984523318 39.232845306396484 1.7056305408477783 6.759152412414551 1.8894875255583323 2.51946097612381 47.49776788570546 445.16735378096115 31.597290977469157 317.95696568919755 -80.5487769502513 1222.5430152835845 UP 0.75 0.25 0.0 GO:0009617 5 response to bacterium 110 127 7 7 6 6 5 5 64 122 2356 0.87343 0.259 0.39093 3.94 24539;170496;360504;24404;54232 lpl;lcn2;hba-a2;gpx1;car3 LPL_32544;LCN2_32481;HBA2_32600;GPX1_33050;CAR3_8196 403.04953 131.05 3.44933 490.20893534033195 359.8017306704509 474.3042622125952 226.564568 88.5948 2.13143 270.85710348212393 203.4378227738792 262.28206987299785 1559.671906 254.163 6.02113 2021.131529790446 1376.7972952867294 1965.078367418095 900.118;972.626;131.05;8.00432;3.44933 487.466;551.931;88.5948;2.69961;2.13143 3428.38;4084.57;254.163;25.2254;6.02113 1 4 1 170496 LCN2_32481 972.626 972.626 551.931 551.931 4084.57 4084.57 972.626 551.931 4084.57 4 24539;360504;24404;54232 LPL_32544;HBA2_32600;GPX1_33050;CAR3_8196 260.6554125 69.52716000000001 430.38645702745293 145.22296 45.647205 231.75068370009944 928.4473825 139.6942 1670.42935214236 900.118;131.05;8.00432;3.44933 487.466;88.5948;2.69961;2.13143 3428.38;254.163;25.2254;6.02113 0 Exp 2,1(0.2);Exp 4,1(0.2);Hill,1(0.2);Linear,1(0.2);Poly 2,1(0.2) 2.367260359246654 14.052469253540039 1.7036563158035278 6.759152412414551 2.209207050702384 1.856990933418274 -26.63754701872216 832.7366070187222 -10.852151065291821 463.9812870652918 -211.92799089519485 3331.271802895195 DOWN 0.2 0.8 0.0 GO:0034284 6 response to monosaccharide 105 109 12 12 10 9 7 7 62 102 2376 0.99177 0.026164 0.026164 6.42 361042;25663;24426;24404;29739;25283;24207 pck2;il1r1;gstp1;gpx1;gclm;gclc;apoc3 PCK2_9440;IL1R1_8893;GSTP1_8762;GPX1_33050;GCLM_8700;GCLC_8699;APOC3_32553 78.98332285714287 76.6218 2.87451 76.18101047961333 56.64743141925777 75.85985454004397 40.51649 27.5215 1.13737 42.07105877722594 26.829725334575155 38.95284567020776 178.53704428571427 185.143 8.23841 175.67275900652342 136.47425434565602 176.73140747427354 4.5 134.236 6.67763;76.6218;122.514;8.00432;190.233;145.958;2.87451 1.48195;27.5215;84.8469;2.69961;69.2223;96.7058;1.13737 37.9425;185.143;216.573;25.2254;496.452;280.185;8.23841 5 2 5 361042;25663;24426;29739;25283 PCK2_9440;IL1R1_8893;GSTP1_8762;GCLM_8700;GCLC_8699 108.40088599999999 122.514 70.11373403038084 55.955690000000004 69.2223 40.14712919908471 243.2591 216.573 167.11874666625525 6.67763;76.6218;122.514;190.233;145.958 1.48195;27.5215;84.8469;69.2223;96.7058 37.9425;185.143;216.573;496.452;280.185 2 24404;24207 GPX1_33050;APOC3_32553 5.439415 5.439415 3.627323437198562 1.9184899999999998 1.9184899999999998 1.1046704978408723 16.731905 16.731905 12.011615820948068 8.00432;2.87451 2.69961;1.13737 25.2254;8.23841 0 Exp 4,1(0.15);Hill,4(0.58);Poly 2,2(0.29) 2.0052921381515354 15.71233868598938 1.5235437154769897 5.5128583908081055 1.447782522335101 1.7603585720062256 22.547640517837415 135.41900519644832 9.34981350303812 71.68316649696187 48.3968431969582 308.67724537447043 UP 0.7142857142857143 0.2857142857142857 0.0 GO:0034654 5 nucleobase-containing compound biosynthetic process 143 160 6 6 6 4 4 4 65 156 2322 0.56097 0.63994 1.0 2.5 83472;116682;499709;24890 ugdh;kynu;gar1;esr1 UGDH_10131;KYNU_8979;GAR1_8683;ESR1_33192 499709(-0.07184) 234.412875 79.8736 12.5403 355.78196442037716 127.98204710471049 257.853833401574 172.2371525 49.0824 3.74981 278.0265939308103 90.0387202940294 201.08547018488795 427.5077 148.262 51.2968 624.9019966130903 241.11816009600963 451.0519448344943 59.3662;100.381;765.364;12.5403 25.4417;72.7231;587.034;3.74981 135.068;161.456;1362.21;51.2968 2 2 2 83472;499709 UGDH_10131;GAR1_8683 412.36510000000004 412.36510000000004 499.21583188278396 306.23785 306.23785 397.10572359215 748.639 748.639 867.7204296788223 59.3662;765.364 25.4417;587.034 135.068;1362.21 2 116682;24890 KYNU_8979;ESR1_33192 56.46065 56.46065 62.112754634173164 38.236455 38.236455 48.77148107974629 106.37639999999999 106.37639999999999 77.89431733008513 100.381;12.5403 72.7231;3.74981 161.456;51.2968 0 Exp 2,1(0.25);Hill,2(0.5);Poly 2,1(0.25) 1.7145801451220302 6.88297963142395 1.5737498998641968 1.957481861114502 0.17121922384867522 1.6758739352226257 -114.25345013196957 583.0792001319696 -100.22890955219418 444.70321455219414 -184.89625668082851 1039.9116566808284 CONFLICT 0.5 0.5 0.0 GO:0006084 8 acetyl-CoA metabolic process 16 16 3 3 3 2 2 2 67 14 2464 0.99172 0.067982 0.067982 12.5 116682;296925 kynu;aass KYNU_8979;AASS_7936 53.09588 53.09588 5.81076 66.87125800243928 38.731099818473034 63.71084152247261 37.663995 37.663995 2.60489 49.58106177566239 27.01336459690336 47.2378008678994 87.76759999999999 87.76759999999999 14.0792 104.21113466957358 65.38174863854778 99.28599048589854 0.0 5.81076 0.5 53.09588 100.381;5.81076 72.7231;2.60489 161.456;14.0792 0 2 0 2 116682;296925 KYNU_8979;AASS_7936 53.09588 53.09588 66.87125800243928 37.663995 37.663995 49.58106177566239 87.76759999999999 87.76759999999999 104.21113466957358 100.381;5.81076 72.7231;2.60489 161.456;14.0792 0 Hill,1(0.5);Poly 2,1(0.5) 2.1425346278957877 4.302563428878784 1.957481861114502 2.3450815677642822 0.2740743809579762 2.151281714439392 -39.582955199999994 145.7747152 -31.051850799999997 106.3798408 -56.661664 232.19686399999998 DOWN 0.0 1.0 0.0 GO:0044242 5 cellular lipid catabolic process 56 64 7 7 7 5 5 5 64 59 2419 0.9931 0.027918 0.027918 7.81 361042;24539;171142;25426;24207 pck2;lpl;ehhadh;cyp1b1;apoc3 PCK2_9440;LPL_32544;EHHADH_8534;CYP1B1_32710;APOC3_32553 261.17642800000004 166.899 2.87451 370.6883336881406 169.16969974662646 274.3650844992322 156.13306400000002 105.26 1.13737 200.7249938175232 108.59505672289214 155.5585502114988 831.697782 299.27 8.23841 1460.6689594198765 459.00592630084225 1040.421083598238 2.5 198.106 6.67763;900.118;166.899;229.313;2.87451 1.48195;487.466;105.26;185.32;1.13737 37.9425;3428.38;384.658;299.27;8.23841 2 3 2 361042;25426 PCK2_9440;CYP1B1_32710 117.99531499999999 117.99531499999999 157.42697985897604 93.400975 93.400975 129.99313179511157 168.60625 168.60625 184.78644736052752 6.67763;229.313 1.48195;185.32 37.9425;299.27 3 24539;171142;24207 LPL_32544;EHHADH_8534;APOC3_32553 356.6305033333333 166.899 477.7656356464853 197.9544566666667 105.26 256.07241321931895 1273.7588033333334 384.658 1875.4245660057659 900.118;166.899;2.87451 487.466;105.26;1.13737 3428.38;384.658;8.23841 0 Exp 2,1(0.2);Exp 4,1(0.2);Hill,1(0.2);Linear,1(0.2);Poly 2,1(0.2) 1.8020984956934825 9.444504499435425 1.5039241313934326 3.1843981742858887 0.7286740056305692 1.528982162475586 -63.74622253638063 586.0990785363806 -19.810150536009132 332.0762785360091 -448.6350116675967 2112.0305756675966 DOWN 0.4 0.6 0.0 GO:0007166 5 cell surface receptor signaling pathway 368 386 14 14 13 5 4 4 65 382 2096 0.014082 0.99579 0.025891 1.04 170496;29200;25663;25317 lcn2;inhba;il1r1;fgf1 LCN2_32481;INHBA_33300;IL1R1_8893;FGF1_8633 453.80505 382.9862 76.6218 443.86172557129777 481.4587320655045 414.45245857495996 265.30847500000004 240.8907 27.5215 269.13068794937243 288.8112579983672 256.5321464337723 1480.41075 825.965 185.143 1837.81517799322 1435.5191550208904 1651.3530775921931 972.626;91.8104;76.6218;674.162 551.931;44.1594;27.5215;437.622 4084.57;186.93;185.143;1465.0 3 1 3 170496;25663;25317 LCN2_32481;IL1R1_8893;FGF1_8633 574.4699333333333 674.162 456.24528788976374 339.02483333333333 437.622 275.7578319442321 1911.571 1465.0 1987.7001724638958 972.626;76.6218;674.162 551.931;27.5215;437.622 4084.57;185.143;1465.0 1 29200 INHBA_33300 91.8104 91.8104 44.1594 44.1594 186.93 186.93 91.8104 44.1594 186.93 0 Hill,2(0.5);Linear,2(0.5) 1.8342469571313382 7.413062334060669 1.5704141855239868 2.2924909591674805 0.31547293432818346 1.7750785946846008 18.82055894012825 888.7895410598719 1.5604008096149755 529.056549190385 -320.6481244333554 3281.4696244333554 UP 0.75 0.25 0.0 GO:2001242 7 regulation of intrinsic apoptotic signaling pathway 62 64 4 4 3 3 2 2 67 62 2416 0.75029 0.52306 0.69168 3.12 94195;24404 s100a9;gpx1 S100A9_9775;GPX1_33050 485.66116 485.66116 8.00432 675.5087812882755 223.40483875080983 564.5842342177599 402.421305 402.421305 2.69961 565.2918422437618 182.9550847440715 472.46589637824513 591.9527 591.9527 25.2254 801.4734338270858 280.7924602565764 669.864371000735 963.318;8.00432 802.143;2.69961 1158.68;25.2254 1 1 1 94195 S100A9_9775 963.318 963.318 802.143 802.143 1158.68 1158.68 963.318 802.143 1158.68 1 24404 GPX1_33050 8.00432 8.00432 2.69961 2.69961 25.2254 25.2254 8.00432 2.69961 25.2254 0 Hill,1(0.5);Poly 2,1(0.5) 1.7446867735305616 3.4902678728103638 1.7056305408477783 1.7846373319625854 0.05586623775706919 1.7451339364051819 -450.54624639999986 1421.8685664 -381.0332172 1185.8758272 -518.8328080000001 1702.7382080000002 CONFLICT 0.5 0.5 0.0 GO:0019439 5 aromatic compound catabolic process 57 68 6 6 6 4 4 4 65 64 2414 0.96486 0.11027 0.11027 5.88 116682;25315;24296;310395 kynu;ephx1;cyp1a1;noct KYNU_8979;EPHX1_8567;CYP1A1_8415;CCRN4L_8232 219.06677499999998 91.71015 27.5708 299.0892665289788 191.85611275426973 285.6675354562527 145.51662499999998 67.8751 12.6303 193.91044589066323 127.33051295735261 185.7342016569823 442.22695 140.721 61.9858 656.7702410809101 385.34045916036894 625.0644616676092 2.5 382.82849999999996 100.381;27.5708;83.0393;665.276 72.7231;12.6303;63.0271;433.686 161.456;61.9858;119.986;1425.48 3 1 3 25315;24296;310395 EPHX1_8567;CYP1A1_8415;CCRN4L_8232 258.6287 83.0393 353.2572838187912 169.78113333333332 63.0271 229.93323672388757 535.8172666666667 119.986 771.0161088535137 27.5708;83.0393;665.276 12.6303;63.0271;433.686 61.9858;119.986;1425.48 1 116682 KYNU_8979 100.381 100.381 72.7231 72.7231 161.456 161.456 100.381 72.7231 161.456 0 Hill,1(0.25);Linear,1(0.25);Poly 2,2(0.5) 2.860056981992266 13.098327040672302 1.7575112581253052 6.292444229125977 2.0958285322353363 2.5241857767105103 -74.04070619839919 512.1742561983991 -44.51561197284997 335.5488619728499 -201.4078862592919 1085.8617862592919 UP 0.75 0.25 0.0 GO:0050727 6 regulation of inflammatory response 108 115 8 8 7 7 6 6 63 109 2369 0.96615 0.088414 0.12788 5.22 94195;259241;24539;25663;24404;24890 s100a9;nr1d2;lpl;il1r1;gpx1;esr1 S100A9_9775;NR1D2_9358;LPL_32544;IL1R1_8893;GPX1_33050;ESR1_33192 328.34380500000003 44.58105 8.00432 468.5120671257235 171.9168880956373 368.5771141586285 220.96553666666668 15.635655 2.2133 343.18670250083994 104.4328038245614 247.0661382298429 816.3578000000001 118.2199 25.2254 1351.8636416862403 507.41584286911973 1175.6227293793686 4.5 931.7180000000001 963.318;9.46041;900.118;76.6218;8.00432;12.5403 802.143;2.2133;487.466;27.5215;2.69961;3.74981 1158.68;49.4216;3428.38;185.143;25.2254;51.2968 3 3 3 94195;259241;25663 S100A9_9775;NR1D2_9358;IL1R1_8893 349.80007 76.6218 532.382241345724 277.2926 27.5215 454.70988886534013 464.4148666666667 185.143 605.0686995096122 963.318;9.46041;76.6218 802.143;2.2133;27.5215 1158.68;49.4216;185.143 3 24539;24404;24890 LPL_32544;GPX1_33050;ESR1_33192 306.88754 12.5403 513.757654719128 164.63847333333334 3.74981 279.5773322540618 1168.3007333333333 51.2968 1957.32946848171 900.118;8.00432;12.5403 487.466;2.69961;3.74981 3428.38;25.2254;51.2968 0 Exp 2,1(0.17);Hill,4(0.67);Poly 2,1(0.17) 1.7919044748971438 10.79595685005188 1.6931662559509277 2.177004337310791 0.18794120587892185 1.718746304512024 -46.54392591290383 703.2315359129038 -53.64101716089388 495.57209049422727 -265.3584004909735 1898.0740004909735 CONFLICT 0.5 0.5 0.0 GO:0071260 5 cellular response to mechanical stimulus 54 54 4 4 3 3 2 2 67 52 2426 0.82149 0.43344 0.6568 3.7 59107;25283 ltbp1;gclc LTBP1_33264;GCLC_8699 457.676 457.676 145.958 440.83582323581646 302.09833393501805 382.00445375878263 267.3664 267.3664 96.7058 241.3505350827298 182.19012581227435 209.14130490105194 1245.6924999999999 1245.6924999999999 280.185 1365.433801072941 763.8101466606498 1183.2109956355032 769.394;145.958 438.027;96.7058 2211.2;280.185 1 1 1 25283 GCLC_8699 145.958 145.958 96.7058 96.7058 280.185 280.185 145.958 96.7058 280.185 1 59107 LTBP1_33264 769.394 769.394 438.027 438.027 2211.2 2211.2 769.394 438.027 2211.2 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.6325622089902851 3.2744020223617554 1.5140434503555298 1.7603585720062256 0.1741710928279964 1.6372010111808777 -153.29127999999997 1068.64328 -67.12837599999995 601.8611759999999 -646.7021999999995 3138.087199999999 CONFLICT 0.5 0.5 0.0 GO:0001934 9 positive regulation of protein phosphorylation 270 289 10 10 9 3 3 3 66 286 2192 0.037041 0.98892 0.079925 1.04 29200;25317;24890 inhba;fgf1;esr1 INHBA_33300;FGF1_8633;ESR1_33192 259.50423333333333 91.8104 12.5403 361.2848388477482 312.0323014020463 383.4142934505651 161.84373666666667 44.1594 3.74981 239.6841080179369 197.5278747956477 253.7485130635508 567.7422666666666 186.93 51.2968 780.001712341334 683.5892753748715 825.9872868117609 91.8104;674.162;12.5403 44.1594;437.622;3.74981 186.93;1465.0;51.2968 1 2 1 25317 FGF1_8633 674.162 674.162 437.622 437.622 1465.0 1465.0 674.162 437.622 1465.0 2 29200;24890 INHBA_33300;ESR1_33192 52.17535 52.17535 56.052425255335734 23.954605 23.954605 28.573895113968096 119.1134 119.1134 95.90715547403126 91.8104;12.5403 44.1594;3.74981 186.93;51.2968 0 Hill,2(0.67);Linear,1(0.34) 1.840539096705386 5.594767212867737 1.5704141855239868 2.2924909591674805 0.3789821981884148 1.7318620681762695 -149.32804863390743 668.3365153005742 -109.38436453121048 433.0718378645438 -314.9127625670644 1450.3972959003977 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0009624 5 response to nematode 1 1 1 1 1 1 1 1 68 0 2478 1.0 0.027091 0.027091 100.0 24296 cyp1a1 CYP1A1_8415 83.0393 83.0393 83.0393 83.0393 63.0271 63.0271 63.0271 63.0271 119.986 119.986 119.986 119.986 0.0 83.0393 0.0 83.0393 83.0393 63.0271 119.986 1 0 1 24296 CYP1A1_8415 83.0393 83.0393 63.0271 63.0271 119.986 119.986 83.0393 63.0271 119.986 0 0 Poly 2,1(1) 6.292444229125976 6.292444229125977 6.292444229125977 6.292444229125977 0.0 6.292444229125977 83.0393 83.0393 63.0271 63.0271 119.986 119.986 UP 1.0 0.0 0.0 GO:0019341 5 dibenzo-p-dioxin catabolic process 1 1 1 1 1 1 1 1 68 0 2478 1.0 0.027091 0.027091 100.0 24296 cyp1a1 CYP1A1_8415 83.0393 83.0393 83.0393 83.0393 63.0271 63.0271 63.0271 63.0271 119.986 119.986 119.986 119.986 0.0 83.0393 0.0 83.0393 83.0393 63.0271 119.986 1 0 1 24296 CYP1A1_8415 83.0393 83.0393 63.0271 63.0271 119.986 119.986 83.0393 63.0271 119.986 0 0 Poly 2,1(1) 6.292444229125976 6.292444229125977 6.292444229125977 6.292444229125977 0.0 6.292444229125977 83.0393 83.0393 63.0271 63.0271 119.986 119.986 UP 1.0 0.0 0.0 GO:2001233 6 regulation of apoptotic signaling pathway 139 145 8 8 7 7 6 6 63 139 2339 0.90571 0.19638 0.2839 4.14 94195;29200;24426;24404;29739;25283 s100a9;inhba;gstp1;gpx1;gclm;gclc S100A9_9775;INHBA_33300;GSTP1_8762;GPX1_33050;GCLM_8700;GCLC_8699 253.63962 134.236 8.00432 352.98114937128184 170.2183539715948 256.88954511143714 183.29616833333333 77.03460000000001 2.69961 305.00772318351613 109.04747181596508 218.58892055823304 394.00756666666666 248.37900000000002 25.2254 404.6081559780113 307.5830566307324 320.11055279568103 963.318;91.8104;122.514;8.00432;190.233;145.958 802.143;44.1594;84.8469;2.69961;69.2223;96.7058 1158.68;186.93;216.573;25.2254;496.452;280.185 4 2 4 94195;24426;29739;25283 S100A9_9775;GSTP1_8762;GCLM_8700;GCLC_8699 355.50575 168.09550000000002 406.1798568125332 263.22950000000003 90.77635000000001 359.4519201870815 537.9725000000001 388.3185 430.79530569749704 963.318;122.514;190.233;145.958 802.143;84.8469;69.2223;96.7058 1158.68;216.573;496.452;280.185 2 29200;24404 INHBA_33300;GPX1_33050 49.90736 49.90736 59.2598474726623 23.429505 23.429505 29.316498655570207 106.07770000000001 106.07770000000001 114.34241920905819 91.8104;8.00432 44.1594;2.69961 186.93;25.2254 0 Hill,3(0.5);Poly 2,3(0.5) 2.248605153440222 14.964768052101135 1.7056305408477783 5.5128583908081055 1.4939565873796883 1.8467147946357727 -28.804123561718797 536.0833635617188 -60.760839539840106 427.35317620650676 70.25361421457876 717.7615191187546 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0006979 4 response to oxidative stress 170 179 17 17 15 12 11 11 58 168 2310 0.99745 0.0075868 0.0075868 6.15 287877;170496;25663;360504;24426;116686;24404;29739;25283;25426;54232 pycr1;lcn2;il1r1;hba-a2;gstp1;gsr;gpx1;gclm;gclc;cyp1b1;car3 PYCR1_9631;LCN2_32481;IL1R1_8893;HBA2_32600;GSTP1_8762;GSR_8755;GPX1_33050;GCLM_8700;GCLC_8699;CYP1B1_32710;CAR3_8196 189.2717590909091 131.05 3.44933 268.8094582003995 181.28681220765228 235.54144993337317 112.76303090909092 84.8469 2.13143 154.5666881873635 112.52254727329995 137.6598887250642 564.6975027272728 239.858 6.02113 1175.1570344488025 486.9531488420476 1026.4377119149349 7.5 168.09550000000002 132.668;972.626;76.6218;131.05;122.514;69.5519;8.00432;190.233;145.958;229.313;3.44933 90.3184;551.931;27.5215;88.5948;84.8469;41.1016;2.69961;69.2223;96.7058;185.32;2.13143 239.858;4084.57;185.143;254.163;216.573;124.212;25.2254;496.452;280.185;299.27;6.02113 8 3 8 287877;170496;25663;24426;116686;29739;25283;25426 PYCR1_9631;LCN2_32481;IL1R1_8893;GSTP1_8762;GSR_8755;GCLM_8700;GCLC_8699;CYP1B1_32710 242.43571250000002 139.313 299.80859793822475 143.3709375 87.58265 171.74584556334514 740.782875 260.0215 1355.5342106168684 132.668;972.626;76.6218;122.514;69.5519;190.233;145.958;229.313 90.3184;551.931;27.5215;84.8469;41.1016;69.2223;96.7058;185.32 239.858;4084.57;185.143;216.573;124.212;496.452;280.185;299.27 3 360504;24404;54232 HBA2_32600;GPX1_33050;CAR3_8196 47.50121666666667 8.00432 72.39120375318561 31.14194666666667 2.69961 49.756441535084015 95.13651 25.2254 138.05531278385595 131.05;8.00432;3.44933 88.5948;2.69961;2.13143 254.163;25.2254;6.02113 0 Exp 4,2(0.19);Hill,3(0.28);Linear,2(0.19);Poly 2,4(0.37) 2.3809575517312385 29.98561942577362 1.6931662559509277 6.759152412414551 1.7582708426611842 1.856990933418274 30.415520783552836 348.12799739826534 21.419955343775257 204.10610647440654 -129.77592526421142 1259.170930718757 UP 0.7272727272727273 0.2727272727272727 0.0 GO:0017015 7 regulation of transforming growth factor beta receptor signaling pathway 30 31 4 4 4 2 2 2 67 29 2449 0.95021 0.20433 0.20433 6.45 338475;59107 nrep;ltbp1 NREP_9364;LTBP1_33264 480.2765 480.2765 191.159 408.87388961940326 350.13543246367243 365.1088367781722 276.9565 276.9565 115.886 227.7880855982156 204.45349752311753 203.40609923051565 1329.634 1329.634 448.068 1246.7225933269997 932.8128447820343 1113.2758715857262 0.5 480.2765 191.159;769.394 115.886;438.027 448.068;2211.2 0 2 0 2 338475;59107 NREP_9364;LTBP1_33264 480.2765 480.2765 408.87388961940326 276.9565 276.9565 227.7880855982156 1329.634 1329.634 1246.7225933269997 191.159;769.394 115.886;438.027 448.068;2211.2 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.8624468829881198 3.805066466331482 1.5140434503555298 2.291023015975952 0.5494075196935787 1.902533233165741 -86.3938 1046.9468 -38.74167999999992 592.6546799999999 -398.2353599999999 3057.5033599999997 DOWN 0.0 1.0 0.0 GO:0055082 5 cellular chemical homeostasis 190 202 16 16 13 14 11 11 58 191 2287 0.99311 0.018028 0.021109 5.45 361042;24567;288001;25663;24404;29739;25283;24890;117517;24207;25748 pck2;mt1;kng1;il1r1;gpx1;gclm;gclc;esr1;c7;apoc3;alas2 PCK2_9440;MT1A_9255;KNG1L1_32433;IL1R1_8893;GPX1_33050;GCLM_8700;GCLC_8699;ESR1_33192;C7_8179;APOC3_32553;ALAS2_8019 288001(0.1788) 135.8621018181818 76.6218 2.87451 235.96982688629262 73.282200590775 131.8435601331187 78.41014090909091 27.5215 1.13737 157.3412370699529 35.857473094923485 84.10563109861408 237.94168272727273 185.143 8.23841 293.4143846640431 163.5067222891955 202.45469581947654 9.5 504.2835 6.67763;818.334;3.87556;76.6218;8.00432;190.233;145.958;12.5403;103.858;2.87451;125.506 1.48195;540.216;1.25511;27.5215;2.69961;69.2223;96.7058;3.74981;32.7314;1.13737;85.7907 37.9425;988.495;13.8374;185.143;25.2254;496.452;280.185;51.2968;293.781;8.23841;236.762 5 6 5 361042;288001;25663;29739;25283 PCK2_9440;KNG1L1_32433;IL1R1_8893;GCLM_8700;GCLC_8699 84.673198 76.6218 83.02874607362573 39.237332 27.5215 42.44732588074153 202.71197999999998 185.143 197.11451351017257 6.67763;3.87556;76.6218;190.233;145.958 1.48195;1.25511;27.5215;69.2223;96.7058 37.9425;13.8374;185.143;496.452;280.185 6 24567;24404;24890;117517;24207;25748 MT1A_9255;GPX1_33050;ESR1_33192;C7_8179;APOC3_32553;ALAS2_8019 178.51952166666663 58.19915 317.8751481729642 111.05414833333333 18.240605000000002 212.73890796744402 267.2997683333333 144.0294 372.59265763522666 818.334;8.00432;12.5403;103.858;2.87451;125.506 540.216;2.69961;3.74981;32.7314;1.13737;85.7907 988.495;25.2254;51.2968;293.781;8.23841;236.762 0 Exp 4,2(0.19);Hill,6(0.55);Poly 2,3(0.28) 1.76323915399572 19.533528685569763 1.5235437154769897 2.3371741771698 0.23040602531244297 1.7586312294006348 -3.5871545589838263 275.31135819534745 -14.572588266029825 171.3928700842116 64.54486207578765 411.3385033787578 CONFLICT 0.45454545454545453 0.5454545454545454 0.0 GO:0007623 3 circadian rhythm 58 63 7 7 5 6 4 4 65 59 2419 0.97372 0.08903 0.08903 6.35 259241;316351;24309;310395 nr1d2;npas2;dbp;noct NR1D2_9358;NPAS2_9350;DBP_8439;CCRN4L_8232 198.44387749999999 59.519549999999995 9.46041 312.1601574446884 188.43991740477534 310.6287894030219 117.567925 17.1862 2.2133 210.87597440670152 112.46021203609702 208.6018459573585 492.61990000000003 247.789 49.4216 629.4621108868852 467.1929373491258 631.9315070152759 2.5 365.65684999999996 9.46041;53.0014;66.0377;665.276 2.2133;14.3825;19.9899;433.686 49.4216;215.15;280.428;1425.48 3 1 3 259241;24309;310395 NR1D2_9358;DBP_8439;CCRN4L_8232 246.92470333333333 66.0377 363.40556270226114 151.96306666666666 19.9899 244.1410662943523 585.1098666666667 280.428 736.8903988784582 9.46041;66.0377;665.276 2.2133;19.9899;433.686 49.4216;280.428;1425.48 1 316351 NPAS2_9350 53.0014 53.0014 14.3825 14.3825 215.15 215.15 53.0014 14.3825 215.15 0 Exp 4,1(0.25);Hill,2(0.5);Linear,1(0.25) 2.094021839184742 8.478425860404968 1.7575112581253052 2.6413023471832275 0.38887119442797113 2.0398061275482178 -107.47307679579467 504.36083179579464 -89.09052991856748 324.2263799185675 -124.25296866914744 1109.4927686691476 UP 0.75 0.25 0.0 GO:0030335 7 positive regulation of cell migration 186 194 5 5 5 3 3 3 66 191 2287 0.21591 0.90741 0.4855 1.55 25663;25317;25426 il1r1;fgf1;cyp1b1 IL1R1_8893;FGF1_8633;CYP1B1_32710 326.69893333333334 229.313 76.6218 310.44578860473104 352.88473331852504 296.70784456192615 216.8211666666667 185.32 27.5215 206.85707058518284 240.5869946468236 191.1476467130723 649.8043333333334 299.27 185.143 708.2825878463576 682.6160033318524 703.9082011997539 76.6218;674.162;229.313 27.5215;437.622;185.32 185.143;1465.0;299.27 3 0 3 25663;25317;25426 IL1R1_8893;FGF1_8633;CYP1B1_32710 326.69893333333334 229.313 310.44578860473104 216.8211666666667 185.32 206.85707058518284 649.8043333333334 299.27 708.2825878463576 76.6218;674.162;229.313 27.5215;437.622;185.32 185.143;1465.0;299.27 0 0 Hill,1(0.34);Linear,2(0.67) 2.0382012337747293 6.447978615760803 1.5704141855239868 3.1843981742858887 0.8984973586526607 1.6931662559509277 -24.603547521331848 678.0014141879985 -17.25964469015358 450.9019780234869 -151.69286646728847 1451.3015331339552 UP 1.0 0.0 0.0 GO:0009064 8 glutamine family amino acid metabolic process 23 24 5 5 5 5 5 5 64 19 2459 0.99997 3.5924E-4 3.5924E-4 20.83 287877;58835;29739;25283;25612 pycr1;phgdh;gclm;gclc;asns PYCR1_9631;PHGDH_9470;GCLM_8700;GCLC_8699;ASNS_8091 119.548216 132.668 6.05608 68.47837781747812 128.37456496674372 56.67280734329755 65.33362 69.2223 2.7438 37.23760024910307 72.628391552552 31.61764573218574 255.45722 246.456 14.3351 171.13896507689884 268.03411430908767 148.62332919713276 0.5 64.44104 1.5 127.747 132.668;122.826;190.233;145.958;6.05608 90.3184;67.6778;69.2223;96.7058;2.7438 239.858;246.456;496.452;280.185;14.3351 5 0 5 287877;58835;29739;25283;25612 PYCR1_9631;PHGDH_9470;GCLM_8700;GCLC_8699;ASNS_8091 119.548216 132.668 68.47837781747812 65.33362 69.2223 37.23760024910307 255.45722 246.456 171.13896507689884 132.668;122.826;190.233;145.958;6.05608 90.3184;67.6778;69.2223;96.7058;2.7438 239.858;246.456;496.452;280.185;14.3351 0 0 Exp 4,1(0.2);Hill,2(0.4);Poly 2,2(0.4) 2.0661831835480284 10.764081120491028 1.7603585720062256 3.5324413776397705 0.7735661485796035 1.7978414297103882 59.52427134679247 179.57216065320756 32.693424253424645 97.97381574657535 105.44730307172395 405.4671369282761 UP 1.0 0.0 0.0 GO:0006631 6 fatty acid metabolic process 129 145 15 15 13 12 10 10 59 135 2343 0.99855 0.004894 0.004894 6.9 361042;24539;84029;24426;24404;25315;171142;25426;24296;290277 pck2;lpl;hao2;gstp1;gpx1;ephx1;ehhadh;cyp1b1;cyp1a1;cryl1 PCK2_9440;LPL_32544;HAO2_8778;GSTP1_8762;GPX1_33050;EPHX1_8567;EHHADH_8534;CYP1B1_32710;CYP1A1_8415;CRYL1_8388 171.779315 102.77664999999999 6.67763 266.51269530043595 134.8328047344968 210.42644166338263 105.169996 73.937 1.48195 146.34978714091287 87.04074517161209 120.7293098355363 493.15676999999994 168.2795 25.2254 1038.8086890944262 339.78256930207607 791.691266975729 6.5 153.8775 6.67763;900.118;140.856;122.514;8.00432;27.5708;166.899;229.313;83.0393;32.8011 1.48195;487.466;93.5219;84.8469;2.69961;12.6303;105.26;185.32;63.0271;15.4462 37.9425;3428.38;282.925;216.573;25.2254;61.9858;384.658;299.27;119.986;74.622 6 4 6 361042;24426;25315;25426;24296;290277 PCK2_9440;GSTP1_8762;EPHX1_8567;CYP1B1_32710;CYP1A1_8415;CRYL1_8388 83.65263833333333 57.920199999999994 82.92614307320952 60.45874166666667 39.23665 69.25844823391884 135.06321666666665 97.304 102.23592131810457 6.67763;122.514;27.5708;229.313;83.0393;32.8011 1.48195;84.8469;12.6303;185.32;63.0271;15.4462 37.9425;216.573;61.9858;299.27;119.986;74.622 4 24539;84029;24404;171142 LPL_32544;HAO2_8778;GPX1_33050;EHHADH_8534 303.96933 153.8775 403.47769772197114 172.2368775 99.39095 215.09241002102803 1030.2971 333.79150000000004 1605.8627609191392 900.118;140.856;8.00432;166.899 487.466;93.5219;2.69961;105.26 3428.38;282.925;25.2254;384.658 0 Exp 2,1(0.1);Hill,4(0.4);Linear,1(0.1);Poly 2,4(0.4) 2.593609109132988 29.443261861801147 1.5039241313934326 6.292444229125977 1.68577800440575 2.420735716819763 6.5930350700331815 336.9655949299668 14.461458160563183 195.8785338394368 -150.70352609957217 1137.0170660995723 UP 0.6 0.4 0.0 GO:0045926 5 negative regulation of growth 66 72 7 7 7 2 2 2 67 70 2408 0.69059 0.58778 1.0 2.78 24567;29200 mt1;inhba MT1A_9255;INHBA_33300 455.07219999999995 455.07219999999995 91.8104 513.7297642520629 269.60333444103304 441.7248810006288 292.1877 292.1877 44.1594 350.7649857123427 165.5530595629402 301.60141061429596 587.7125 587.7125 186.93 566.7920470617951 383.08686743724036 487.34990059410194 818.334;91.8104 540.216;44.1594 988.495;186.93 0 2 0 2 24567;29200 MT1A_9255;INHBA_33300 455.07219999999995 455.07219999999995 513.7297642520629 292.1877 292.1877 350.7649857123427 587.7125 587.7125 566.7920470617951 818.334;91.8104 540.216;44.1594 988.495;186.93 0 Hill,1(0.5);Poly 2,1(0.5) 2.3147247506261865 4.62966513633728 2.2924909591674805 2.3371741771698 0.03159580645467682 2.31483256816864 -256.920928 1167.065328 -193.94776799999994 778.3231679999999 -197.82119999999998 1373.2462 DOWN 0.0 1.0 0.0 GO:0032354 6 response to follicle-stimulating hormone 20 22 7 7 6 6 5 5 64 17 2461 0.99998 2.3216E-4 2.3216E-4 22.73 29200;29739;25283;25426;25612 inhba;gclm;gclc;cyp1b1;asns INHBA_33300;GCLM_8700;GCLC_8699;CYP1B1_32710;ASNS_8091 132.67409600000002 145.958 6.05608 87.36493994738436 158.89219722467277 83.22449808661302 79.63025999999999 69.2223 2.7438 68.44693287392796 104.06594587099573 74.28102867337799 255.43442 280.185 14.3351 175.67395994948143 280.5935514426206 153.28614323430233 0.5 48.93324 1.5 118.88419999999999 91.8104;190.233;145.958;229.313;6.05608 44.1594;69.2223;96.7058;185.32;2.7438 186.93;496.452;280.185;299.27;14.3351 4 1 4 29739;25283;25426;25612 GCLM_8700;GCLC_8699;CYP1B1_32710;ASNS_8091 142.89002 168.09550000000002 97.37081846317336 88.497975 82.96405 75.64655333185489 272.560525 289.72749999999996 197.97246556689606 190.233;145.958;229.313;6.05608 69.2223;96.7058;185.32;2.7438 496.452;280.185;299.27;14.3351 1 29200 INHBA_33300 91.8104 91.8104 44.1594 44.1594 186.93 186.93 91.8104 44.1594 186.93 0 Hill,3(0.6);Linear,1(0.2);Poly 2,1(0.2) 2.440922288611896 12.678481340408325 1.7603585720062256 3.5324413776397705 0.7854331576435246 2.2924909591674805 56.09534972756495 209.25284227243503 19.63387805507257 139.62664194492743 101.44940480114258 409.4194351988574 UP 0.8 0.2 0.0 GO:0065008 3 regulation of biological quality 821 880 52 52 45 35 29 29 40 851 1627 0.92527 0.11669 0.19989 3.3 192247;299270;94195;287877;58835;361042;259241;24567;59107;24539;170496;288001;64194;29200;25663;116686;24404;29739;25283;499709;24890;25426;24296;310395;117517;24207;301111;25748;114628 sez6;serpina6;s100a9;pycr1;phgdh;pck2;nr1d2;mt1;ltbp1;lpl;lcn2;kng1;insig1;inhba;il1r1;gsr;gpx1;gclm;gclc;gar1;esr1;cyp1b1;cyp1a1;noct;c7;apoc3;ano10;alas2;abcg5 SEZ6_9819;SERPINA6_32325;S100A9_9775;PYCR1_9631;PHGDH_9470;PCK2_9440;NR1D2_9358;MT1A_9255;LTBP1_33264;LPL_32544;LCN2_32481;KNG1L1_32433;INSIG1_8906;INHBA_33300;IL1R1_8893;GSR_8755;GPX1_33050;GCLM_8700;GCLC_8699;GAR1_8683;ESR1_33192;CYP1B1_32710;CYP1A1_8415;CCRN4L_8232;C7_8179;APOC3_32553;ANO10_8049;ALAS2_8019;ABCG5_7947 288001(0.1788);499709(-0.07184) 273.05520448275865 103.858 2.87451 344.84131830255944 192.52708109769878 276.66074873071653 174.8895496551724 63.0271 1.13737 234.7530159026646 120.75941606885246 181.7092242735846 650.6544520689655 236.762 8.23841 1020.4978506272331 465.3355646895543 852.7277481801418 10.6392;25.7745;963.318;132.668;122.826;6.67763;9.46041;818.334;769.394;900.118;972.626;3.87556;37.6554;91.8104;76.6218;69.5519;8.00432;190.233;145.958;765.364;12.5403;229.313;83.0393;665.276;103.858;2.87451;9.9207;125.506;565.363 3.96047;8.17372;802.143;90.3184;67.6778;1.48195;2.2133;540.216;438.027;487.466;551.931;1.25511;13.2791;44.1594;27.5215;41.1016;2.69961;69.2223;96.7058;587.034;3.74981;185.32;63.0271;433.686;32.7314;1.13737;2.9165;85.7907;386.851 29.4997;103.274;1158.68;239.858;246.456;37.9425;49.4216;988.495;2211.2;3428.38;4084.57;13.8374;101.065;186.93;185.143;124.212;25.2254;496.452;280.185;1362.21;51.2968;299.27;119.986;1425.48;293.781;8.23841;33.1883;236.762;1047.94 17 12 17 94195;287877;58835;361042;259241;170496;288001;64194;25663;116686;29739;25283;499709;25426;24296;310395;301111 S100A9_9775;PYCR1_9631;PHGDH_9470;PCK2_9440;NR1D2_9358;LCN2_32481;KNG1L1_32433;INSIG1_8906;IL1R1_8893;GSR_8755;GCLM_8700;GCLC_8699;GAR1_8683;CYP1B1_32710;CYP1A1_8415;CCRN4L_8232;ANO10_8049 263.7873352941176 122.826 342.91638773389224 178.63732117647058 67.6778 250.76125991613281 603.4092235294117 239.858 1010.4581436223996 963.318;132.668;122.826;6.67763;9.46041;972.626;3.87556;37.6554;76.6218;69.5519;190.233;145.958;765.364;229.313;83.0393;665.276;9.9207 802.143;90.3184;67.6778;1.48195;2.2133;551.931;1.25511;13.2791;27.5215;41.1016;69.2223;96.7058;587.034;185.32;63.0271;433.686;2.9165 1158.68;239.858;246.456;37.9425;49.4216;4084.57;13.8374;101.065;185.143;124.212;496.452;280.185;1362.21;299.27;119.986;1425.48;33.1883 12 192247;299270;24567;59107;24539;29200;24404;24890;117517;24207;25748;114628 SEZ6_9819;SERPINA6_32325;MT1A_9255;LTBP1_33264;LPL_32544;INHBA_33300;GPX1_33050;ESR1_33192;C7_8179;APOC3_32553;ALAS2_8019;ABCG5_7947 286.18468583333333 97.83420000000001 362.39604200430654 169.58020666666664 38.4454 220.81975327205876 717.5851925000001 211.846 1075.8308003947323 10.6392;25.7745;818.334;769.394;900.118;91.8104;8.00432;12.5403;103.858;2.87451;125.506;565.363 3.96047;8.17372;540.216;438.027;487.466;44.1594;2.69961;3.74981;32.7314;1.13737;85.7907;386.851 29.4997;103.274;988.495;2211.2;3428.38;186.93;25.2254;51.2968;293.781;8.23841;236.762;1047.94 0 Exp 2,3(0.11);Exp 4,4(0.14);Exp 5,1(0.04);Hill,11(0.38);Linear,4(0.14);Poly 2,6(0.21) 1.9571557184044055 60.10544192790985 1.5140434503555298 6.292444229125977 0.9434915244961916 1.783576488494873 147.54577105231493 398.5646379132024 89.44816992996128 260.33092938038357 279.23113284585554 1022.0777712920757 CONFLICT 0.5862068965517241 0.41379310344827586 0.0 GO:0080134 5 regulation of response to stress 340 358 22 22 18 16 12 12 57 346 2132 0.83823 0.25577 0.38332 3.35 94195;287877;259241;316351;24539;288001;64194;25663;24426;24404;84586;24890 s100a9;pycr1;nr1d2;npas2;lpl;kng1;insig1;il1r1;gstp1;gpx1;fgl2;esr1 S100A9_9775;PYCR1_9631;NR1D2_9358;NPAS2_9350;LPL_32544;KNG1L1_32433;INSIG1_8906;IL1R1_8893;GSTP1_8762;GPX1_33050;FGL2_32918;ESR1_33192 288001(0.1788) 205.5152658333333 64.8116 3.87556 343.22331847425073 133.77880783286784 275.16536074864143 135.45756916666667 20.951999999999998 1.25511 249.8251491424503 81.7385317239128 184.27795355583152 500.8101 200.1465 13.8374 972.036419645263 364.7527173769541 876.9846220256437 963.318;132.668;9.46041;53.0014;900.118;3.87556;37.6554;76.6218;122.514;8.00432;146.406;12.5403 802.143;90.3184;2.2133;14.3825;487.466;1.25511;13.2791;27.5215;84.8469;2.69961;95.6156;3.74981 1158.68;239.858;49.4216;215.15;3428.38;13.8374;101.065;185.143;216.573;25.2254;325.091;51.2968 7 5 7 94195;287877;259241;288001;64194;25663;24426 S100A9_9775;PYCR1_9631;NR1D2_9358;KNG1L1_32433;INSIG1_8906;IL1R1_8893;GSTP1_8762 192.30188142857145 76.6218 343.784162191993 145.9396157142857 27.5215 291.73088160163366 280.654 185.143 396.3866853087442 963.318;132.668;9.46041;3.87556;37.6554;76.6218;122.514 802.143;90.3184;2.2133;1.25511;13.2791;27.5215;84.8469 1158.68;239.858;49.4216;13.8374;101.065;185.143;216.573 5 316351;24539;24404;84586;24890 NPAS2_9350;LPL_32544;GPX1_33050;FGL2_32918;ESR1_33192 224.01400400000003 53.0014 382.0229827785733 120.78270400000001 14.3825 208.59730431326295 809.02864 215.15 1469.3871244480767 53.0014;900.118;8.00432;146.406;12.5403 14.3825;487.466;2.69961;95.6156;3.74981 215.15;3428.38;25.2254;325.091;51.2968 0 Exp 2,1(0.09);Exp 4,1(0.09);Exp 5,1(0.09);Hill,5(0.42);Poly 2,4(0.34) 2.0109522603913743 25.916226625442505 1.5755720138549805 5.5128583908081055 1.0961240914933406 1.7482547760009766 11.318392026333356 399.71213964033336 -5.894315598910737 276.80945393224414 -49.17127877342642 1050.7914787734264 CONFLICT 0.5833333333333334 0.4166666666666667 0.0 GO:0043408 7 regulation of MAPK cascade 190 203 9 9 6 5 3 3 66 200 2278 0.18631 0.92309 0.36613 1.48 24426;25317;24890 gstp1;fgf1;esr1 GSTP1_8762;FGF1_8633;ESR1_33192 269.73876666666666 122.514 12.5403 354.5309117943926 354.51182900792645 395.09058613068737 175.40623666666667 84.8469 3.74981 230.67729495331577 228.7813651240092 258.4224103633176 577.6232666666666 216.573 51.2968 772.9211833800478 775.9669325620047 849.8321014518591 122.514;674.162;12.5403 84.8469;437.622;3.74981 216.573;1465.0;51.2968 2 1 2 24426;25317 GSTP1_8762;FGF1_8633 398.338 398.338 390.07404162799656 261.23445000000004 261.23445000000004 249.44966544376237 840.7865 840.7865 882.7711975163779 122.514;674.162 84.8469;437.622 216.573;1465.0 1 24890 ESR1_33192 12.5403 12.5403 3.74981 3.74981 51.2968 51.2968 12.5403 3.74981 51.2968 0 Hill,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 2.465858295627844 8.815134644508362 1.5704141855239868 5.5128583908081055 2.2310261063147117 1.7318620681762695 -131.45072735998383 670.9282606933173 -85.62969607430716 436.44216940764056 -297.01938977552925 1452.2659231088624 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0006732 5 coenzyme metabolic process 61 67 10 10 9 7 6 6 63 61 2417 0.99812 0.0086155 0.0086155 8.96 680308;116682;25283;81508;360887;296925 mthfd2;kynu;gclc;bhmt;coq8a;aass MTHFD2_9261;KYNU_8979;GCLC_8699;BHMT_8143;ADCK3_7987;AASS_7936 234.22356 123.1695 5.5396 270.40227079464256 144.92208521894423 226.50307436590262 154.1168 84.71445 1.97501 177.16556726532508 95.40852904969604 148.74465975760336 463.66034999999994 220.82049999999998 14.0792 539.8581013967495 287.15532940550185 449.42578799082946 2.5 123.1695 622.58;100.381;145.958;5.5396;525.072;5.81076 414.266;72.7231;96.7058;1.97501;336.426;2.60489 1250.29;161.456;280.185;37.8319;1038.12;14.0792 2 4 2 680308;25283 MTHFD2_9261;GCLC_8699 384.269 384.269 337.02264826269476 255.48590000000002 255.48590000000002 224.54897085495628 765.2375 765.2375 685.9678239629757 622.58;145.958 414.266;96.7058 1250.29;280.185 4 116682;81508;360887;296925 KYNU_8979;BHMT_8143;ADCK3_7987;AASS_7936 159.20084 53.09588 247.96624274157102 103.43225 37.663995 158.83835337198653 312.87177499999996 99.64394999999999 487.796289619498 100.381;5.5396;525.072;5.81076 72.7231;1.97501;336.426;2.60489 161.456;37.8319;1038.12;14.0792 0 Exp 2,1(0.17);Exp 4,1(0.17);Hill,1(0.17);Linear,1(0.17);Poly 2,2(0.34) 1.7888703600241933 10.850245356559753 1.5278362035751343 2.3450815677642822 0.30290874477846075 1.716427981853485 17.856681012659635 450.59043898734046 12.35482166834612 295.87877833165385 31.68390190295196 895.6367980970479 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0009266 4 response to temperature stimulus 80 87 7 7 7 4 4 4 65 83 2395 0.91573 0.20799 0.29592 4.6 24539;25663;25283;25317 lpl;il1r1;gclc;fgf1 LPL_32544;IL1R1_8893;GCLC_8699;FGF1_8633 449.21495000000004 410.06 76.6218 401.95570608100184 456.5410144044584 376.1050291646218 262.328825 267.1639 27.5215 233.79471839797657 275.23299050250307 226.92580223267797 1339.6770000000001 872.5925 185.143 1509.2888095344772 1240.9732176253897 1319.698521420368 900.118;76.6218;145.958;674.162 487.466;27.5215;96.7058;437.622 3428.38;185.143;280.185;1465.0 3 1 3 25663;25283;25317 IL1R1_8893;GCLC_8699;FGF1_8633 298.9139333333333 145.958 326.81831468021096 187.2831 96.7058 219.542229380887 643.4426666666667 280.185 713.074739705687 76.6218;145.958;674.162 27.5215;96.7058;437.622 185.143;280.185;1465.0 1 24539 LPL_32544 900.118 900.118 487.466 487.466 3428.38 3428.38 900.118 487.466 3428.38 0 Exp 2,1(0.25);Hill,1(0.25);Linear,1(0.25);Poly 2,1(0.25) 1.6804447386889552 6.727595329284668 1.5704141855239868 1.7603585720062256 0.07996895261220001 1.6984112858772278 55.29835804061827 843.1315419593817 33.21000096998296 491.44764903001703 -139.42603334378805 2818.780033343788 UP 0.75 0.25 0.0 GO:0006796 5 phosphate-containing compound metabolic process 383 419 19 18 16 8 6 6 63 413 2065 0.047617 0.98016 0.097772 1.43 171497;116682;310395;54232;360887;296925 sgk2;kynu;noct;car3;coq8a;aass SGK2_32380;KYNU_8979;CCRN4L_8232;CAR3_8196;ADCK3_7987;AASS_7936 242.72651499999998 128.3755 3.44933 282.619666593093 227.34202130367356 287.62529128687896 158.03123666666667 86.66955 2.13143 182.6725631686329 148.1968922936254 186.73458673269477 498.0602216666666 252.33049999999997 6.02113 594.2044510436156 473.67767568253043 611.4577139511242 156.37;100.381;665.276;3.44933;525.072;5.81076 100.616;72.7231;433.686;2.13143;336.426;2.60489 343.205;161.456;1425.48;6.02113;1038.12;14.0792 2 4 2 171497;310395 SGK2_32380;CCRN4L_8232 410.823 410.823 359.85088358652115 267.151 267.151 235.51605560980332 884.3425 884.3425 765.2839916086708 156.37;665.276 100.616;433.686 343.205;1425.48 4 116682;54232;360887;296925 KYNU_8979;CAR3_8196;ADCK3_7987;AASS_7936 158.6782725 53.09588 248.39983662091345 103.471355 37.663995 158.80506496249092 304.91908249999994 87.76759999999999 493.9949610824486 100.381;3.44933;525.072;5.81076 72.7231;2.13143;336.426;2.60489 161.456;6.02113;1038.12;14.0792 0 Exp 2,1(0.17);Exp 4,1(0.17);Hill,1(0.17);Linear,1(0.17);Poly 2,2(0.34) 2.340565020590927 16.306000232696533 1.5869897603988647 6.759152412414551 1.9959744179109749 1.9286326169967651 16.583683353329576 468.86934664667035 11.862743875303664 304.19972945802965 22.597637070501207 973.5228062628321 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0044282 4 small molecule catabolic process 107 120 8 8 8 5 5 5 64 115 2363 0.89657 0.22314 0.25732 4.17 361042;116682;171142;24296;296925 pck2;kynu;ehhadh;cyp1a1;aass PCK2_9440;KYNU_8979;EHHADH_8534;CYP1A1_8415;AASS_7936 72.561538 83.0393 5.81076 68.1535369516089 67.82015503060155 69.770978005926 49.019408 63.0271 1.48195 45.648663815007446 45.43864199434298 46.62520412305478 143.62434000000002 119.986 14.0792 147.41485599551356 137.37467660871474 151.16160047851116 6.67763;100.381;166.899;83.0393;5.81076 1.48195;72.7231;105.26;63.0271;2.60489 37.9425;161.456;384.658;119.986;14.0792 2 3 2 361042;24296 PCK2_9440;CYP1A1_8415 44.858464999999995 44.858464999999995 53.995854679729355 32.254525 32.254525 43.51899291414324 78.96425 78.96425 58.0135152022785 6.67763;83.0393 1.48195;63.0271 37.9425;119.986 3 116682;171142;296925 KYNU_8979;EHHADH_8534;AASS_7936 91.03025333333333 100.381 80.95018600344618 60.195996666666666 72.7231 52.46154916432638 186.73106666666664 161.456 186.5778215614422 100.381;166.899;5.81076 72.7231;105.26;2.60489 161.456;384.658;14.0792 0 Hill,2(0.4);Poly 2,3(0.6) 2.3145186481824758 13.62791395187378 1.5039241313934326 6.292444229125977 2.0237072220890604 1.957481861114502 12.822328919910234 132.3007470800898 9.006589974022518 89.03222602597748 14.40952155147022 272.8391584485298 DOWN 0.4 0.6 0.0 GO:0072593 4 reactive oxygen species metabolic process 40 44 10 10 7 7 5 5 64 39 2439 0.99901 0.0060306 0.0060306 11.36 287167;360504;24404;25426;24296 hba-a1;hba-a2;gpx1;cyp1b1;cyp1a1 LOC287167_9118;HBA2_32600;GPX1_33050;CYP1B1_32710;CYP1A1_8415 120.137724 131.05 8.00432 81.91138632182266 128.92150038014125 82.7796776173147 87.328782 88.5948 2.69961 66.04946819116805 95.53572267786663 67.95229394851322 206.55928 254.163 25.2254 129.92132504285817 212.26710502700453 125.62830939285905 1.5 107.04465 3.5 189.2975 149.282;131.05;8.00432;229.313;83.0393 97.0024;88.5948;2.69961;185.32;63.0271 334.152;254.163;25.2254;299.27;119.986 2 3 2 25426;24296 CYP1B1_32710;CYP1A1_8415 156.17615 156.17615 103.43112517924666 124.17354999999999 124.17354999999999 86.47413888096834 209.628 209.628 126.77293215824898 229.313;83.0393 185.32;63.0271 299.27;119.986 3 287167;360504;24404 LOC287167_9118;HBA2_32600;GPX1_33050 96.11210666666666 131.05 76.84619710482842 62.76560333333333 88.5948 52.18826113964742 204.51346666666666 254.163 160.33626591340257 149.282;131.05;8.00432 97.0024;88.5948;2.69961 334.152;254.163;25.2254 0 Hill,1(0.2);Linear,1(0.2);Poly 2,3(0.6) 2.6114229285931936 14.95289659500122 1.743384599685669 6.292444229125977 1.9388509965778196 1.948032259941101 48.33922824483794 191.93621975516203 29.433870504760556 145.22369349523942 92.67821750711077 320.4403424928892 DOWN 0.4 0.6 0.0 GO:0031325 6 positive regulation of cellular metabolic process 693 746 33 33 27 18 13 13 56 733 1745 0.032226 0.98393 0.059933 1.74 360243;94195;259241;316351;64194;29200;24426;25283;25317;24890;24309;25426;24207 top2a;s100a9;nr1d2;npas2;insig1;inhba;gstp1;gclc;fgf1;esr1;dbp;cyp1b1;apoc3 TOP2A_10059;S100A9_9775;NR1D2_9358;NPAS2_9350;INSIG1_8906;INHBA_33300;GSTP1_8762;GCLC_8699;FGF1_8633;ESR1_33192;DBP_8439;CYP1B1_32710;APOC3_32553 185.2803938461542 66.0377 4.48597E-12 294.7274660650567 149.83227850872697 241.74468961462293 131.19608307692343 19.9899 4.48597E-12 235.37782606387546 100.50137312627318 177.38395795945831 331.71060076923106 215.15 4.48599E-12 451.71409206896135 300.22775582600764 451.29808590311455 4.48597E-12;963.318;9.46041;53.0014;37.6554;91.8104;122.514;145.958;674.162;12.5403;66.0377;229.313;2.87451 4.48597E-12;802.143;2.2133;14.3825;13.2791;44.1594;84.8469;96.7058;437.622;3.74981;19.9899;185.32;1.13737 4.48599E-12;1158.68;49.4216;215.15;101.065;186.93;216.573;280.185;1465.0;51.2968;280.428;299.27;8.23841 9 4 9 360243;94195;259241;64194;24426;25283;25317;24309;25426 TOP2A_10059;S100A9_9775;NR1D2_9358;INSIG1_8906;GSTP1_8762;GCLC_8699;FGF1_8633;DBP_8439;CYP1B1_32710 249.82427888888938 122.514 338.2921656504248 182.45777777777826 84.8469 270.83301616898416 427.846955555556 280.185 518.1160233729192 4.48597E-12;963.318;9.46041;37.6554;122.514;145.958;674.162;66.0377;229.313 4.48597E-12;802.143;2.2133;13.2791;84.8469;96.7058;437.622;19.9899;185.32 4.48599E-12;1158.68;49.4216;101.065;216.573;280.185;1465.0;280.428;299.27 4 316351;29200;24890;24207 NPAS2_9350;INHBA_33300;ESR1_33192;APOC3_32553 40.0566525 32.770849999999996 40.766318793529685 15.85727 9.066155 19.718447815445987 115.40380250000001 119.1134 101.09307586531675 53.0014;91.8104;12.5403;2.87451 14.3825;44.1594;3.74981;1.13737 215.15;186.93;51.2968;8.23841 0 Exp 4,2(0.16);Exp 5,1(0.08);Hill,5(0.39);Linear,2(0.16);Poly 2,3(0.24) 2.1326976201447474 29.7219660282135 1.5235437154769897 5.5128583908081055 1.0764398808221296 1.9026079177856445 25.064718252087687 345.4960694402207 3.2432392983178886 259.148926855529 86.15602317104413 577.2651783674181 UP 0.6923076923076923 0.3076923076923077 0.0 GO:2001237 8 negative regulation of extrinsic apoptotic signaling pathway 46 48 5 5 5 4 4 4 65 44 2434 0.99125 0.039219 0.039219 8.33 24426;24404;29739;25283 gstp1;gpx1;gclm;gclc GSTP1_8762;GPX1_33050;GCLM_8700;GCLC_8699 116.67733 134.236 8.00432 77.69960112284319 109.94040504411596 88.24085438615595 63.368652499999996 77.03460000000001 2.69961 41.98284739441843 55.499614436232385 45.63127072523567 254.60885000000002 248.37900000000002 25.2254 194.25562340197513 251.64530032084335 217.6718609358792 1.5 134.236 122.514;8.00432;190.233;145.958 84.8469;2.69961;69.2223;96.7058 216.573;25.2254;496.452;280.185 3 1 3 24426;29739;25283 GSTP1_8762;GCLM_8700;GCLC_8699 152.90166666666667 145.958 34.38933875975705 83.59166666666668 84.8469 13.784679941998307 331.07 280.185 146.71409638817943 122.514;190.233;145.958 84.8469;69.2223;96.7058 216.573;496.452;280.185 1 24404 GPX1_33050 8.00432 8.00432 2.69961 2.69961 25.2254 25.2254 8.00432 2.69961 25.2254 0 Hill,2(0.5);Poly 2,2(0.5) 2.3978480220310447 10.966646552085876 1.7603585720062256 5.5128583908081055 1.848607951742972 1.8467147946357727 40.53172089961366 192.8229391003863 22.22546205346997 104.51184294653004 64.23833906606433 444.97936093393565 UP 0.75 0.25 0.0 GO:0008150 1 biological_process 2293 2547 137 134 115 86 69 69 0 2478 0 1.0 1.0 1.0 2.71 83472;308843;360243;266730;171497;192247;299270;94195;291317;293656;287877;293820;363465;58835;361042;24614;338475;259241;316351;680308;24567;313108;24552;29685;312538;59107;24539;287598;287167;170496;116682;288001;293502;64194;29200;25663;360504;84029;24426;300850;116686;24404;29739;25283;499709;84586;25317;24890;25315;171142;298452;24309;25426;24296;290277;289185;310395;54232;117517;81508;25612;24207;301111;25748;26760;286921;360887;114628;296925 ugdh;tsku;top2a;slc17a3;sgk2;sez6;serpina6;s100a9;rpp38;rgd1307603;pycr1;psat1;pir;phgdh;pck2;orm1;nrep;nr1d2;npas2;mthfd2;mt1;mms22l;me1;mcm6;mcm2;ltbp1;lpl;ska2;hba-a1;lcn2;kynu;kng1;kif22;insig1;inhba;il1r1;hba-a2;hao2;gstp1;gsta4;gsr;gpx1;gclm;gclc;gar1;fgl2;fgf1;esr1;ephx1;ehhadh;dph2;dbp;cyp1b1;cyp1a1;cryl1;creg1;noct;car3;c7;bhmt;asns;apoc3;ano10;alas2;akr7a3;akr1b8;coq8a;abcg5;aass UGDH_10131;TSKU_10094;TOP2A_10059;SLC17A3_9840;SGK2_32380;SEZ6_9819;SERPINA6_32325;S100A9_9775;RPP38_9741;RGD1307603_9684;PYCR1_9631;PSAT1_9583;PIR_9487;PHGDH_9470;PCK2_9440;ORM1_9400;NREP_9364;NR1D2_9358;NPAS2_9350;MTHFD2_9261;MT1A_9255;MMS22L_33129;ME1_9215;MCM6_9210;MCM2_9206;LTBP1_33264;LPL_32544;LOC691962_32591;LOC287167_9118;LCN2_32481;KYNU_8979;KNG1L1_32433;KIF22_8963;INSIG1_8906;INHBA_33300;IL1R1_8893;HBA2_32600;HAO2_8778;GSTP1_8762;GSTA4_8757;GSR_8755;GPX1_33050;GCLM_8700;GCLC_8699;GAR1_8683;FGL2_32918;FGF1_8633;ESR1_33192;EPHX1_8567;EHHADH_8534;DPH2_8490;DBP_8439;CYP1B1_32710;CYP1A1_8415;CRYL1_8388;CREG1_8380;CCRN4L_8232;CAR3_8196;C7_8179;BHMT_8143;ASNS_8091;APOC3_32553;ANO10_8049;ALAS2_8019;AKR7A3_8015;AKR1B8_8013;ADCK3_7987;ABCG5_7947;AASS_7936 288001(0.1788);499709(-0.07184) 214.54819675362324 93.3839 4.48597E-12 289.5620964979349 176.51010593930368 256.94824738351736 138.10126266666674 49.0864 4.48597E-12 201.5653844899649 113.76966646447002 178.32782327404226 472.53807985507257 215.15 4.48599E-12 754.6642264158069 388.2091016644958 666.06558650531 59.3662;92.2997;4.48597E-12;93.3839;156.37;10.6392;25.7745;963.318;916.962;32.0155;132.668;27.1579;152.213;122.826;6.67763;662.49;191.159;9.46041;53.0014;622.58;818.334;4.13516;13.1175;1.87441;3.76863;769.394;900.118;2.47312;149.282;972.626;100.381;3.87556;0.961856;37.6554;91.8104;76.6218;131.05;140.856;122.514;339.498;69.5519;8.00432;190.233;145.958;765.364;146.406;674.162;12.5403;27.5708;166.899;734.134;66.0377;229.313;83.0393;32.8011;97.6763;665.276;3.44933;103.858;5.5396;6.05608;2.87451;9.9207;125.506;57.1167;267.583;525.072;565.363;5.81076 25.4417;49.0864;4.48597E-12;68.9252;100.616;3.96047;8.17372;802.143;769.912;12.3892;90.3184;10.0144;56.4566;67.6778;1.48195;432.445;115.886;2.2133;14.3825;414.266;540.216;1.24709;6.20444;0.496857;0.956203;438.027;487.466;0.810493;97.0024;551.931;72.7231;1.25511;0.281971;13.2791;44.1594;27.5215;88.5948;93.5219;84.8469;260.156;41.1016;2.69961;69.2223;96.7058;587.034;95.6156;437.622;3.74981;12.6303;105.26;463.289;19.9899;185.32;63.0271;15.4462;36.7323;433.686;2.13143;32.7314;1.97501;2.7438;1.13737;2.9165;85.7907;33.0666;114.994;336.426;386.851;2.60489 135.068;185.899;4.48599E-12;143.418;343.205;29.4997;103.274;1158.68;1051.72;78.5761;239.858;103.876;371.778;246.456;37.9425;1413.32;448.068;49.4216;215.15;1250.29;988.495;20.8956;28.4614;9.53;22.9217;2211.2;3428.38;10.3838;334.152;4084.57;161.456;13.8374;4.47267;101.065;186.93;185.143;254.163;282.925;216.573;486.944;124.212;25.2254;496.452;280.185;1362.21;325.091;1465.0;51.2968;61.9858;384.658;1764.85;280.428;299.27;119.986;74.622;282.14;1425.48;6.02113;293.781;37.8319;14.3351;8.23841;33.1883;236.762;102.949;310.791;1038.12;1047.94;14.0792 42 27 42 83472;308843;360243;266730;171497;94195;287877;293820;363465;58835;361042;24614;259241;680308;313108;24552;29685;312538;287598;170496;288001;293502;64194;25663;24426;300850;116686;29739;25283;499709;25317;25315;24309;25426;24296;290277;289185;310395;25612;301111;26760;286921 UGDH_10131;TSKU_10094;TOP2A_10059;SLC17A3_9840;SGK2_32380;S100A9_9775;PYCR1_9631;PSAT1_9583;PIR_9487;PHGDH_9470;PCK2_9440;ORM1_9400;NR1D2_9358;MTHFD2_9261;MMS22L_33129;ME1_9215;MCM6_9210;MCM2_9206;LOC691962_32591;LCN2_32481;KNG1L1_32433;KIF22_8963;INSIG1_8906;IL1R1_8893;GSTP1_8762;GSTA4_8757;GSR_8755;GCLM_8700;GCLC_8699;GAR1_8683;FGF1_8633;EPHX1_8567;DBP_8439;CYP1B1_32710;CYP1A1_8415;CRYL1_8388;CREG1_8380;CCRN4L_8232;ASNS_8091;ANO10_8049;AKR7A3_8015;AKR1B8_8013 192.0855180000001 79.83054999999999 274.3488033673083 124.34073366666676 38.91695 195.18569245091822 418.981996904762 164.28050000000002 728.5364272085375 59.3662;92.2997;4.48597E-12;93.3839;156.37;963.318;132.668;27.1579;152.213;122.826;6.67763;662.49;9.46041;622.58;4.13516;13.1175;1.87441;3.76863;2.47312;972.626;3.87556;0.961856;37.6554;76.6218;122.514;339.498;69.5519;190.233;145.958;765.364;674.162;27.5708;66.0377;229.313;83.0393;32.8011;97.6763;665.276;6.05608;9.9207;57.1167;267.583 25.4417;49.0864;4.48597E-12;68.9252;100.616;802.143;90.3184;10.0144;56.4566;67.6778;1.48195;432.445;2.2133;414.266;1.24709;6.20444;0.496857;0.956203;0.810493;551.931;1.25511;0.281971;13.2791;27.5215;84.8469;260.156;41.1016;69.2223;96.7058;587.034;437.622;12.6303;19.9899;185.32;63.0271;15.4462;36.7323;433.686;2.7438;2.9165;33.0666;114.994 135.068;185.899;4.48599E-12;143.418;343.205;1158.68;239.858;103.876;371.778;246.456;37.9425;1413.32;49.4216;1250.29;20.8956;28.4614;9.53;22.9217;10.3838;4084.57;13.8374;4.47267;101.065;185.143;216.573;486.944;124.212;496.452;280.185;1362.21;1465.0;61.9858;280.428;299.27;119.986;74.622;282.14;1425.48;14.3351;33.1883;102.949;310.791 27 192247;299270;291317;293656;338475;316351;24567;59107;24539;287167;116682;29200;360504;84029;24404;84586;24890;171142;298452;54232;117517;81508;24207;25748;360887;114628;296925 SEZ6_9819;SERPINA6_32325;RPP38_9741;RGD1307603_9684;NREP_9364;NPAS2_9350;MT1A_9255;LTBP1_33264;LPL_32544;LOC287167_9118;KYNU_8979;INHBA_33300;HBA2_32600;HAO2_8778;GPX1_33050;FGL2_32918;ESR1_33192;EHHADH_8534;DPH2_8490;CAR3_8196;C7_8179;BHMT_8143;APOC3_32553;ALAS2_8019;ADCK3_7987;ABCG5_7947;AASS_7936 249.49014148148152 125.506 313.8732494892826 159.50653 85.7907 213.07507280317145 555.8475422222223 254.163 800.4324026972655 10.6392;25.7745;916.962;32.0155;191.159;53.0014;818.334;769.394;900.118;149.282;100.381;91.8104;131.05;140.856;8.00432;146.406;12.5403;166.899;734.134;3.44933;103.858;5.5396;2.87451;125.506;525.072;565.363;5.81076 3.96047;8.17372;769.912;12.3892;115.886;14.3825;540.216;438.027;487.466;97.0024;72.7231;44.1594;88.5948;93.5219;2.69961;95.6156;3.74981;105.26;463.289;2.13143;32.7314;1.97501;1.13737;85.7907;336.426;386.851;2.60489 29.4997;103.274;1051.72;78.5761;448.068;215.15;988.495;2211.2;3428.38;334.152;161.456;186.93;254.163;282.925;25.2254;325.091;51.2968;384.658;1764.85;6.02113;293.781;37.8319;8.23841;236.762;1038.12;1047.94;14.0792 0 Exp 2,4(0.06);Exp 4,14(0.21);Exp 5,2(0.03);Hill,23(0.34);Linear,9(0.14);Poly 2,17(0.25) 2.0521429260429076 152.58222234249115 1.503517508506775 6.759152412414551 1.0809927229276557 1.7846373319625854 146.22420393753617 282.8721895697104 90.54064596847122 185.6618793648624 294.4703223419298 650.6058373682154 UP 0.6086956521739131 0.391304347826087 0.0 GO:0050794 4 regulation of cellular process 1555 1680 92 91 77 52 41 41 28 1639 839 0.15081 0.90042 0.24849 2.44 308843;360243;171497;192247;299270;94195;287877;363465;361042;24614;338475;259241;316351;24567;312538;59107;24539;287598;170496;288001;64194;29200;25663;360504;24426;116686;24404;29739;25283;84586;25317;24890;298452;24309;25426;24296;289185;310395;25612;24207;114628 tsku;top2a;sgk2;sez6;serpina6;s100a9;pycr1;pir;pck2;orm1;nrep;nr1d2;npas2;mt1;mcm2;ltbp1;lpl;ska2;lcn2;kng1;insig1;inhba;il1r1;hba-a2;gstp1;gsr;gpx1;gclm;gclc;fgl2;fgf1;esr1;dph2;dbp;cyp1b1;cyp1a1;creg1;noct;asns;apoc3;abcg5 TSKU_10094;TOP2A_10059;SGK2_32380;SEZ6_9819;SERPINA6_32325;S100A9_9775;PYCR1_9631;PIR_9487;PCK2_9440;ORM1_9400;NREP_9364;NR1D2_9358;NPAS2_9350;MT1A_9255;MCM2_9206;LTBP1_33264;LPL_32544;LOC691962_32591;LCN2_32481;KNG1L1_32433;INSIG1_8906;INHBA_33300;IL1R1_8893;HBA2_32600;GSTP1_8762;GSR_8755;GPX1_33050;GCLM_8700;GCLC_8699;FGL2_32918;FGF1_8633;ESR1_33192;DPH2_8490;DBP_8439;CYP1B1_32710;CYP1A1_8415;CREG1_8380;CCRN4L_8232;ASNS_8091;APOC3_32553;ABCG5_7947 288001(0.1788) 245.92529658536597 97.6763 4.48597E-12 315.4403154648332 204.6312519962718 278.8988120644275 153.55414721951234 56.4566 4.48597E-12 209.41324047737947 128.07141500296427 180.69326416429524 592.9240831707318 239.858 4.48599E-12 910.156221610592 492.8733033580504 812.0794893522676 92.2997;4.48597E-12;156.37;10.6392;25.7745;963.318;132.668;152.213;6.67763;662.49;191.159;9.46041;53.0014;818.334;3.76863;769.394;900.118;2.47312;972.626;3.87556;37.6554;91.8104;76.6218;131.05;122.514;69.5519;8.00432;190.233;145.958;146.406;674.162;12.5403;734.134;66.0377;229.313;83.0393;97.6763;665.276;6.05608;2.87451;565.363 49.0864;4.48597E-12;100.616;3.96047;8.17372;802.143;90.3184;56.4566;1.48195;432.445;115.886;2.2133;14.3825;540.216;0.956203;438.027;487.466;0.810493;551.931;1.25511;13.2791;44.1594;27.5215;88.5948;84.8469;41.1016;2.69961;69.2223;96.7058;95.6156;437.622;3.74981;463.289;19.9899;185.32;63.0271;36.7323;433.686;2.7438;1.13737;386.851 185.899;4.48599E-12;343.205;29.4997;103.274;1158.68;239.858;371.778;37.9425;1413.32;448.068;49.4216;215.15;988.495;22.9217;2211.2;3428.38;10.3838;4084.57;13.8374;101.065;186.93;185.143;254.163;216.573;124.212;25.2254;496.452;280.185;325.091;1465.0;51.2968;1764.85;280.428;299.27;119.986;282.14;1425.48;14.3351;8.23841;1047.94 26 15 26 308843;360243;171497;94195;287877;363465;361042;24614;259241;312538;287598;170496;288001;64194;25663;24426;116686;29739;25283;25317;24309;25426;24296;289185;310395;25612 TSKU_10094;TOP2A_10059;SGK2_32380;S100A9_9775;PYCR1_9631;PIR_9487;PCK2_9440;ORM1_9400;NR1D2_9358;MCM2_9206;LOC691962_32591;LCN2_32481;KNG1L1_32433;INSIG1_8906;IL1R1_8893;GSTP1_8762;GSR_8755;GCLM_8700;GCLC_8699;FGF1_8633;DBP_8439;CYP1B1_32710;CYP1A1_8415;CREG1_8380;CCRN4L_8232;ASNS_8091 216.24363576923093 94.988 298.4040776238257 138.51968292307708 52.7715 210.11543483908267 508.5417730769232 228.21550000000002 860.812777211797 92.2997;4.48597E-12;156.37;963.318;132.668;152.213;6.67763;662.49;9.46041;3.76863;2.47312;972.626;3.87556;37.6554;76.6218;122.514;69.5519;190.233;145.958;674.162;66.0377;229.313;83.0393;97.6763;665.276;6.05608 49.0864;4.48597E-12;100.616;802.143;90.3184;56.4566;1.48195;432.445;2.2133;0.956203;0.810493;551.931;1.25511;13.2791;27.5215;84.8469;41.1016;69.2223;96.7058;437.622;19.9899;185.32;63.0271;36.7323;433.686;2.7438 185.899;4.48599E-12;343.205;1158.68;239.858;371.778;37.9425;1413.32;49.4216;22.9217;10.3838;4084.57;13.8374;101.065;185.143;216.573;124.212;496.452;280.185;1465.0;280.428;299.27;119.986;282.14;1425.48;14.3351 15 192247;299270;338475;316351;24567;59107;24539;29200;360504;24404;84586;24890;298452;24207;114628 SEZ6_9819;SERPINA6_32325;NREP_9364;NPAS2_9350;MT1A_9255;LTBP1_33264;LPL_32544;INHBA_33300;HBA2_32600;GPX1_33050;FGL2_32918;ESR1_33192;DPH2_8490;APOC3_32553;ABCG5_7947 297.3735086666667 131.05 347.58031576011746 179.61388533333331 88.5948 212.86821044569493 739.186754 254.163 1003.7211732325286 10.6392;25.7745;191.159;53.0014;818.334;769.394;900.118;91.8104;131.05;8.00432;146.406;12.5403;734.134;2.87451;565.363 3.96047;8.17372;115.886;14.3825;540.216;438.027;487.466;44.1594;88.5948;2.69961;95.6156;3.74981;463.289;1.13737;386.851 29.4997;103.274;448.068;215.15;988.495;2211.2;3428.38;186.93;254.163;25.2254;325.091;51.2968;1764.85;8.23841;1047.94 0 Exp 2,2(0.05);Exp 4,7(0.18);Exp 5,1(0.03);Hill,14(0.35);Linear,7(0.18);Poly 2,10(0.25) 2.0395012035751345 89.5331084728241 1.503517508506775 6.292444229125977 1.019651647063294 1.7846373319625854 149.3688351791215 342.4817579916103 89.45263425242638 217.6556601865982 314.3247419416495 871.5234243998136 UP 0.6341463414634146 0.36585365853658536 0.0 GO:0034754 5 cellular hormone metabolic process 34 41 6 6 4 5 3 3 66 38 2440 0.9765 0.097729 0.097729 7.32 24890;25426;24296 esr1;cyp1b1;cyp1a1 ESR1_33192;CYP1B1_32710;CYP1A1_8415 108.29753333333333 83.0393 12.5403 110.5716266935751 121.669852312072 109.12337094992397 84.03230333333333 63.0271 3.74981 92.58967220735276 95.24120636685387 91.35802231041968 156.85093333333333 119.986 51.2968 128.03102929295434 171.71771578056473 127.34922097478203 1.5 156.17615 12.5403;229.313;83.0393 3.74981;185.32;63.0271 51.2968;299.27;119.986 2 1 2 25426;24296 CYP1B1_32710;CYP1A1_8415 156.17615 156.17615 103.43112517924666 124.17354999999999 124.17354999999999 86.47413888096834 209.628 209.628 126.77293215824898 229.313;83.0393 185.32;63.0271 299.27;119.986 1 24890 ESR1_33192 12.5403 12.5403 3.74981 3.74981 51.2968 51.2968 12.5403 3.74981 51.2968 0 Hill,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 3.2617700989489102 11.208704471588135 1.7318620681762695 6.292444229125977 2.3298326501178805 3.1843981742858887 -16.826041201756652 233.42110786842332 -20.742774125931547 188.80738079259822 11.970184848585689 301.731681818081 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0046677 4 response to antibiotic 202 218 21 21 17 12 9 9 60 209 2269 0.93415 0.13068 0.18668 4.13 94195;170496;360504;24426;116686;24404;25426;24296;54232 s100a9;lcn2;hba-a2;gstp1;gsr;gpx1;cyp1b1;cyp1a1;car3 S100A9_9775;LCN2_32481;HBA2_32600;GSTP1_8762;GSR_8755;GPX1_33050;CYP1B1_32710;CYP1A1_8415;CAR3_8196 286.9850944444445 122.514 3.44933 392.0006535261821 212.32962801688734 309.87309268936804 202.42171555555558 84.8469 2.13143 281.59265527209885 146.61254616619178 205.15008778225845 698.7445033333333 216.573 6.02113 1316.4165166562368 535.0619312028579 1174.7320108887918 963.318;972.626;131.05;122.514;69.5519;8.00432;229.313;83.0393;3.44933 802.143;551.931;88.5948;84.8469;41.1016;2.69961;185.32;63.0271;2.13143 1158.68;4084.57;254.163;216.573;124.212;25.2254;299.27;119.986;6.02113 6 3 6 94195;170496;24426;116686;25426;24296 S100A9_9775;LCN2_32481;GSTP1_8762;GSR_8755;CYP1B1_32710;CYP1A1_8415 406.72703333333334 175.9135 438.34889105330086 288.0616 135.08345 315.4008765172412 1000.5485 257.9215 1561.1508114564394 963.318;972.626;122.514;69.5519;229.313;83.0393 802.143;551.931;84.8469;41.1016;185.32;63.0271 1158.68;4084.57;216.573;124.212;299.27;119.986 3 360504;24404;54232 HBA2_32600;GPX1_33050;CAR3_8196 47.50121666666667 8.00432 72.39120375318561 31.14194666666667 2.69961 49.756441535084015 95.13651 25.2254 138.05531278385595 131.05;8.00432;3.44933 88.5948;2.69961;2.13143 254.163;25.2254;6.02113 0 Exp 4,2(0.23);Hill,1(0.12);Linear,2(0.23);Poly 2,4(0.45) 2.908673783888068 30.85672962665558 1.7056305408477783 6.759152412414551 2.140173091733625 1.948032259941101 30.87800080733882 543.0921880815501 18.447847444450957 386.3955836666602 -161.31428754874116 1558.8032942154077 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0042326 9 negative regulation of phosphorylation 137 147 8 8 6 4 2 2 67 145 2333 0.22808 0.91645 0.43302 1.36 24426;24207 gstp1;apoc3 GSTP1_8762;APOC3_32553 62.694255 62.694255 2.87451 84.59789467670014 17.275953947508892 55.05596827538883 42.992135000000005 42.992135000000005 1.13737 59.19157631293874 11.213792961743772 38.521638867130825 112.405705 112.405705 8.23841 147.31480134471911 33.316408244661915 95.87187790340914 122.514;2.87451 84.8469;1.13737 216.573;8.23841 1 1 1 24426 GSTP1_8762 122.514 122.514 84.8469 84.8469 216.573 216.573 122.514 84.8469 216.573 1 24207 APOC3_32553 2.87451 2.87451 1.13737 1.13737 8.23841 8.23841 2.87451 1.13737 8.23841 0 Exp 4,1(0.5);Poly 2,1(0.5) 2.8981167601789752 7.036402106285095 1.5235437154769897 5.5128583908081055 2.820871459213642 3.5182010531425476 -54.55244519999998 179.94095519999996 -39.04320439999998 125.02747439999999 -91.76219320000003 316.57360320000004 CONFLICT 0.5 0.5 0.0 GO:0030258 5 lipid modification 64 70 5 5 5 3 3 3 66 67 2411 0.88064 0.29437 0.43673 4.29 84029;171142;24296 hao2;ehhadh;cyp1a1 HAO2_8778;EHHADH_8534;CYP1A1_8415 130.26476666666667 140.856 83.0393 42.92135818754259 125.74819703189137 47.083092911226615 87.26966666666668 93.5219 63.0271 21.799593501791104 84.79170654066488 23.843532200240215 262.52299999999997 282.925 119.986 133.5102921088858 251.15238580901263 147.13806229688 140.856;166.899;83.0393 93.5219;105.26;63.0271 282.925;384.658;119.986 1 2 1 24296 CYP1A1_8415 83.0393 83.0393 63.0271 63.0271 119.986 119.986 83.0393 63.0271 119.986 2 84029;171142 HAO2_8778;EHHADH_8534 153.8775 153.8775 18.415181902441223 99.39095 99.39095 8.300090108245866 333.79150000000004 333.79150000000004 71.9360941704508 140.856;166.899 93.5219;105.26 282.925;384.658 0 Poly 2,3(1) 2.7175949907744967 9.917213201522827 1.5039241313934326 6.292444229125977 2.6048914674549843 2.120844841003418 81.69467756768498 178.83485576564837 62.601104360758974 111.93822897257436 111.44188194624451 413.60411805375554 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0097191 6 extrinsic apoptotic signaling pathway 41 42 2 2 2 2 2 2 67 40 2438 0.89671 0.3158 0.3158 4.76 170496;29200 lcn2;inhba LCN2_32481;INHBA_33300 532.2182 532.2182 91.8104 622.8306837348975 527.5890495106922 622.7962769101745 298.0452 298.0452 44.1594 359.04874165394324 295.37659246103664 359.02890684579427 2135.75 2135.75 186.93 2756.047674623935 2115.265846321131 2755.8954232147707 972.626;91.8104 551.931;44.1594 4084.57;186.93 1 1 1 170496 LCN2_32481 972.626 972.626 551.931 551.931 4084.57 4084.57 972.626 551.931 4084.57 1 29200 INHBA_33300 91.8104 91.8104 44.1594 44.1594 186.93 186.93 91.8104 44.1594 186.93 0 Hill,1(0.5);Linear,1(0.5) 2.0632825609008023 4.149481892585754 1.856990933418274 2.2924909591674805 0.30794502141418 2.074740946292877 -330.981088 1395.417488 -199.570968 795.661368 -1683.9372000000003 5955.4372 CONFLICT 0.5 0.5 0.0 GO:0010647 6 positive regulation of cell communication 426 450 21 21 17 13 10 10 59 440 2038 0.30262 0.80311 0.63059 2.22 94195;361042;24614;24539;29200;25663;24404;25317;24890;25426 s100a9;pck2;orm1;lpl;inhba;il1r1;gpx1;fgf1;esr1;cyp1b1 S100A9_9775;PCK2_9440;ORM1_9400;LPL_32544;INHBA_33300;IL1R1_8893;GPX1_33050;FGF1_8633;ESR1_33192;CYP1B1_32710 362.505545 160.5617 6.67763 392.2342135612484 264.5317907964226 336.20852144406604 242.46082700000002 114.7397 1.48195 280.6302813577484 173.19351711212832 224.57737662008776 825.11877 243.1 25.2254 1085.0144877264963 613.1104120824348 955.6371896552464 963.318;6.67763;662.49;900.118;91.8104;76.6218;8.00432;674.162;12.5403;229.313 802.143;1.48195;432.445;487.466;44.1594;27.5215;2.69961;437.622;3.74981;185.32 1158.68;37.9425;1413.32;3428.38;186.93;185.143;25.2254;1465.0;51.2968;299.27 6 4 6 94195;361042;24614;25663;25317;25426 S100A9_9775;PCK2_9440;ORM1_9400;IL1R1_8893;FGF1_8633;CYP1B1_32710 435.430405 445.9015 385.2975704112012 314.4222416666667 308.8825 304.59485897431097 759.8925833333333 728.975 655.2705444662089 963.318;6.67763;662.49;76.6218;674.162;229.313 802.143;1.48195;432.445;27.5215;437.622;185.32 1158.68;37.9425;1413.32;185.143;1465.0;299.27 4 24539;29200;24404;24890 LPL_32544;INHBA_33300;GPX1_33050;ESR1_33192 253.118255 52.17535 433.0463746058969 134.518705 23.954605 236.08852488988117 922.9580500000001 119.1134 1671.7848429703497 900.118;91.8104;8.00432;12.5403 487.466;44.1594;2.69961;3.74981 3428.38;186.93;25.2254;51.2968 0 Exp 2,1(0.1);Hill,5(0.5);Linear,3(0.3);Poly 2,1(0.1) 1.8263213720695786 18.74402093887329 1.528982162475586 3.1843981742858887 0.5085381222379699 1.704643428325653 119.39626074470402 605.614829255296 68.52437657714262 416.3972774228574 152.61982320267862 1497.6177167973212 UP 0.6 0.4 0.0 GO:0048468 4 cell development 159 163 11 11 11 7 7 7 62 156 2322 0.92964 0.14884 0.2061 4.29 94195;58835;360504;24426;24404;24890;25748 s100a9;phgdh;hba-a2;gstp1;gpx1;esr1;alas2 S100A9_9775;PHGDH_9470;HBA2_32600;GSTP1_8762;GPX1_33050;ESR1_33192;ALAS2_8019 212.25123142857143 122.826 8.00432 335.626420715587 126.90281741685897 234.25833252464767 162.21466000000004 84.8469 2.69961 284.67757604927925 90.45205353162754 196.83884377309167 312.73660000000007 236.762 25.2254 385.0275439317037 211.9765646735442 278.0069908459224 963.318;122.826;131.05;122.514;8.00432;12.5403;125.506 802.143;67.6778;88.5948;84.8469;2.69961;3.74981;85.7907 1158.68;246.456;254.163;216.573;25.2254;51.2968;236.762 3 4 3 94195;58835;24426 S100A9_9775;PHGDH_9470;GSTP1_8762 402.88599999999997 122.826 485.34837416437273 318.22256666666664 84.8469 419.17530204777495 540.5696666666666 246.456 535.5077371545003 963.318;122.826;122.514 802.143;67.6778;84.8469 1158.68;246.456;216.573 4 360504;24404;24890;25748 HBA2_32600;GPX1_33050;ESR1_33192;ALAS2_8019 69.27515500000001 69.02315 68.19334864353536 45.20873 44.770255 48.4943800519421 141.86180000000002 144.0294 120.31026073093956 131.05;8.00432;12.5403;125.506 88.5948;2.69961;3.74981;85.7907 254.163;25.2254;51.2968;236.762 0 Exp 4,1(0.15);Hill,2(0.29);Poly 2,4(0.58) 2.098144237683331 16.239493250846863 1.7056305408477783 5.5128583908081055 1.4101098291363368 1.7846373319625854 -36.38430050955907 460.8867633667019 -48.677439617659644 373.1067596176597 27.504203837080354 597.9689961629196 CONFLICT 0.42857142857142855 0.5714285714285714 0.0 GO:1901615 4 organic hydroxy compound metabolic process 134 145 20 20 16 11 7 7 62 138 2340 0.96029 0.094293 0.11085 4.83 361042;64194;84029;25315;25426;24296;24207 pck2;insig1;hao2;ephx1;cyp1b1;cyp1a1;apoc3 PCK2_9440;INSIG1_8906;HAO2_8778;EPHX1_8567;CYP1B1_32710;CYP1A1_8415;APOC3_32553 75.42666285714286 37.6554 2.87451 83.39369627764773 72.27119669850981 87.25726594349456 52.913959999999996 13.2791 1.13737 68.0715336185254 52.23894955721512 71.88688140327604 130.20181571428571 101.065 8.23841 116.11920408653368 118.06832007433866 114.10588884136867 6.67763;37.6554;140.856;27.5708;229.313;83.0393;2.87451 1.48195;13.2791;93.5219;12.6303;185.32;63.0271;1.13737 37.9425;101.065;282.925;61.9858;299.27;119.986;8.23841 5 2 5 361042;64194;25315;25426;24296 PCK2_9440;INSIG1_8906;EPHX1_8567;CYP1B1_32710;CYP1A1_8415 76.851226 37.6554 89.68290183919049 55.14769 13.2791 76.5631019542573 124.04986 101.065 103.09381795092276 6.67763;37.6554;27.5708;229.313;83.0393 1.48195;13.2791;12.6303;185.32;63.0271 37.9425;101.065;61.9858;299.27;119.986 2 84029;24207 HAO2_8778;APOC3_32553 71.86525499999999 71.86525499999999 97.5676472572238 47.329635 47.329635 65.32572763973204 145.581705 145.581705 194.23275049000893 140.856;2.87451 93.5219;1.13737 282.925;8.23841 0 Exp 4,1(0.15);Exp 5,1(0.15);Hill,2(0.29);Linear,1(0.15);Poly 2,2(0.29) 2.4949216389565767 19.70763874053955 1.5235437154769897 6.292444229125977 1.674745323354415 2.120844841003418 13.647748104032424 137.20557761025333 2.4858621911305363 103.34205780886946 44.179505507803185 216.2241259207682 UP 0.7142857142857143 0.2857142857142857 0.0 GO:2000112 7 regulation of cellular macromolecule biosynthetic process 538 577 27 27 22 17 13 13 56 564 1914 0.27251 0.81834 0.55951 2.25 360243;94195;259241;316351;64194;29200;25283;25317;24890;298452;24309;25426;289185 top2a;s100a9;nr1d2;npas2;insig1;inhba;gclc;fgf1;esr1;dph2;dbp;cyp1b1;creg1 TOP2A_10059;S100A9_9775;NR1D2_9358;NPAS2_9350;INSIG1_8906;INHBA_33300;GCLC_8699;FGF1_8633;ESR1_33192;DPH2_8490;DBP_8439;CYP1B1_32710;CREG1_8380 239.62053153846185 91.8104 4.48597E-12 326.04799305325224 211.73050764233398 285.5000190208965 163.04508538461576 36.7323 4.48597E-12 250.29841887090328 139.13253166899236 201.65027309315334 471.8781846153849 280.185 4.48599E-12 586.7702516149991 448.5342675426361 591.0385163760423 4.48597E-12;963.318;9.46041;53.0014;37.6554;91.8104;145.958;674.162;12.5403;734.134;66.0377;229.313;97.6763 4.48597E-12;802.143;2.2133;14.3825;13.2791;44.1594;96.7058;437.622;3.74981;463.289;19.9899;185.32;36.7323 4.48599E-12;1158.68;49.4216;215.15;101.065;186.93;280.185;1465.0;51.2968;1764.85;280.428;299.27;282.14 9 4 9 360243;94195;259241;64194;25283;25317;24309;25426;289185 TOP2A_10059;S100A9_9775;NR1D2_9358;INSIG1_8906;GCLC_8699;FGF1_8633;DBP_8439;CYP1B1_32710;CREG1_8380 247.06453444444494 97.6763 339.5595068224889 177.11171111111162 36.7323 273.46274625881114 435.1321777777782 280.428 515.2268762207907 4.48597E-12;963.318;9.46041;37.6554;145.958;674.162;66.0377;229.313;97.6763 4.48597E-12;802.143;2.2133;13.2791;96.7058;437.622;19.9899;185.32;36.7323 4.48599E-12;1158.68;49.4216;101.065;280.185;1465.0;280.428;299.27;282.14 4 316351;29200;24890;298452 NPAS2_9350;INHBA_33300;ESR1_33192;DPH2_8490 222.87152500000002 72.4059 342.37475588741813 131.3951775 29.27095 221.9225817183552 554.5567 201.04000000000002 810.0260690312543 53.0014;91.8104;12.5403;734.134 14.3825;44.1594;3.74981;463.289 215.15;186.93;51.2968;1764.85 0 Exp 4,2(0.16);Exp 5,1(0.08);Hill,5(0.39);Linear,3(0.24);Poly 2,2(0.16) 1.9539765023031825 25.968265533447266 1.5704141855239868 3.1843981742858887 0.4711699437299336 1.7603585720062256 62.37882352749031 416.8622395494334 26.981314963312144 299.10885580591923 152.90624237961725 790.8501268511527 UP 0.6923076923076923 0.3076923076923077 0.0 GO:0006082 4 organic acid metabolic process 306 341 33 33 29 27 23 23 46 318 2160 1.0 1.3563E-5 1.3563E-5 6.74 83472;266730;287877;293820;58835;361042;680308;24552;24539;116682;84029;24426;24404;29739;25283;25315;171142;25426;24296;290277;81508;25612;296925 ugdh;slc17a3;pycr1;psat1;phgdh;pck2;mthfd2;me1;lpl;kynu;hao2;gstp1;gpx1;gclm;gclc;ephx1;ehhadh;cyp1b1;cyp1a1;cryl1;bhmt;asns;aass UGDH_10131;SLC17A3_9840;PYCR1_9631;PSAT1_9583;PHGDH_9470;PCK2_9440;MTHFD2_9261;ME1_9215;LPL_32544;KYNU_8979;HAO2_8778;GSTP1_8762;GPX1_33050;GCLM_8700;GCLC_8699;EPHX1_8567;EHHADH_8534;CYP1B1_32710;CYP1A1_8415;CRYL1_8388;BHMT_8143;ASNS_8091;AASS_7936 140.9943952173913 93.3839 5.5396 210.8675843080548 117.52472167936884 169.2439592596297 86.10968695652174 67.6778 1.48195 124.71254033278737 74.03839998682642 101.324355366066 351.4493173913043 143.418 14.0792 719.4709612287588 271.06626357472464 575.5082100956092 16.5 143.40699999999998 59.3662;93.3839;132.668;27.1579;122.826;6.67763;622.58;13.1175;900.118;100.381;140.856;122.514;8.00432;190.233;145.958;27.5708;166.899;229.313;83.0393;32.8011;5.5396;6.05608;5.81076 25.4417;68.9252;90.3184;10.0144;67.6778;1.48195;414.266;6.20444;487.466;72.7231;93.5219;84.8469;2.69961;69.2223;96.7058;12.6303;105.26;185.32;63.0271;15.4462;1.97501;2.7438;2.60489 135.068;143.418;239.858;103.876;246.456;37.9425;1250.29;28.4614;3428.38;161.456;282.925;216.573;25.2254;496.452;280.185;61.9858;384.658;299.27;119.986;74.622;37.8319;14.3351;14.0792 16 7 16 83472;266730;287877;293820;58835;361042;680308;24552;24426;29739;25283;25315;25426;24296;290277;25612 UGDH_10131;SLC17A3_9840;PYCR1_9631;PSAT1_9583;PHGDH_9470;PCK2_9440;MTHFD2_9261;ME1_9215;GSTP1_8762;GCLM_8700;GCLC_8699;EPHX1_8567;CYP1B1_32710;CYP1A1_8415;CRYL1_8388;ASNS_8091 119.70390062499999 88.2116 150.12935225033897 75.892018125 65.35245 102.56824577316343 234.298675 139.243 298.9384586771186 59.3662;93.3839;132.668;27.1579;122.826;6.67763;622.58;13.1175;122.514;190.233;145.958;27.5708;229.313;83.0393;32.8011;6.05608 25.4417;68.9252;90.3184;10.0144;67.6778;1.48195;414.266;6.20444;84.8469;69.2223;96.7058;12.6303;185.32;63.0271;15.4462;2.7438 135.068;143.418;239.858;103.876;246.456;37.9425;1250.29;28.4614;216.573;496.452;280.185;61.9858;299.27;119.986;74.622;14.3351 7 24539;116682;84029;24404;171142;81508;296925 LPL_32544;KYNU_8979;HAO2_8778;GPX1_33050;EHHADH_8534;BHMT_8143;AASS_7936 189.65838285714287 100.381 320.4998320188572 109.46435857142858 72.7231 172.6647122979506 619.2222142857144 161.456 1246.7343033973523 900.118;100.381;140.856;8.00432;166.899;5.5396;5.81076 487.466;72.7231;93.5219;2.69961;105.26;1.97501;2.60489 3428.38;161.456;282.925;25.2254;384.658;37.8319;14.0792 0 Exp 2,1(0.05);Exp 4,3(0.14);Hill,9(0.4);Linear,2(0.09);Poly 2,8(0.35) 2.235553203370354 56.33829700946808 1.5039241313934326 6.292444229125977 1.2569400551364704 1.90879225730896 54.815290877566554 227.17349955721602 35.141136901323236 137.07823701172026 57.4099882043821 645.4886465782266 UP 0.6956521739130435 0.30434782608695654 0.0 GO:0032101 5 regulation of response to external stimulus 254 266 16 16 13 13 10 10 59 256 2222 0.90118 0.17724 0.31426 3.76 94195;259241;24539;288001;25663;24426;24404;84586;25317;24890 s100a9;nr1d2;lpl;kng1;il1r1;gstp1;gpx1;fgl2;fgf1;esr1 S100A9_9775;NR1D2_9358;LPL_32544;KNG1L1_32433;IL1R1_8893;GSTP1_8762;GPX1_33050;FGL2_32918;FGF1_8633;ESR1_33192 288001(0.1788) 291.70203899999996 99.5679 3.87556 392.205832380156 238.6727557298717 362.7290360953231 194.513283 56.184200000000004 1.25511 281.13696369228 150.05527780216494 241.57755590781912 691.86482 200.858 13.8374 1087.737308922793 609.9000086811709 1033.359063469204 963.318;9.46041;900.118;3.87556;76.6218;122.514;8.00432;146.406;674.162;12.5403 802.143;2.2133;487.466;1.25511;27.5215;84.8469;2.69961;95.6156;437.622;3.74981 1158.68;49.4216;3428.38;13.8374;185.143;216.573;25.2254;325.091;1465.0;51.2968 6 4 6 94195;259241;288001;25663;24426;25317 S100A9_9775;NR1D2_9358;KNG1L1_32433;IL1R1_8893;GSTP1_8762;FGF1_8633 308.32529500000004 99.5679 408.18479783081085 225.933635 56.184200000000004 327.6074682259191 514.7758333333334 200.858 629.7007469995813 963.318;9.46041;3.87556;76.6218;122.514;674.162 802.143;2.2133;1.25511;27.5215;84.8469;437.622 1158.68;49.4216;13.8374;185.143;216.573;1465.0 4 24539;24404;84586;24890 LPL_32544;GPX1_33050;FGL2_32918;ESR1_33192 266.767155 79.47315 427.08687604731983 147.382755 49.682705 230.86799056530705 957.4983 188.1939 1652.828816218308 900.118;8.00432;146.406;12.5403 487.466;2.69961;95.6156;3.74981 3428.38;25.2254;325.091;51.2968 0 Exp 2,1(0.1);Exp 4,1(0.1);Hill,4(0.4);Linear,1(0.1);Poly 2,3(0.3) 1.9384996967976715 21.114155054092407 1.5704141855239868 5.5128583908081055 1.2071542496511465 1.704643428325653 48.61034558299184 534.7937324170082 20.262787612593485 368.76377838740655 17.678251140908856 1366.0513888590908 UP 0.6 0.4 0.0 GO:0051054 7 positive regulation of DNA metabolic process 56 60 3 3 3 2 2 2 67 58 2420 0.77941 0.48831 0.67703 3.33 316351;25426 npas2;cyp1b1 NPAS2_9350;CYP1B1_32710 141.1572 141.1572 53.0014 124.67112796185012 207.15801481221482 82.6478979498417 99.85125 99.85125 14.3825 120.87106540907548 163.84031414531412 80.12873262905607 257.21 257.21 215.15 59.481822433412454 288.69963846963844 39.43212571118814 53.0014;229.313 14.3825;185.32 215.15;299.27 1 1 1 25426 CYP1B1_32710 229.313 229.313 185.32 185.32 299.27 299.27 229.313 185.32 299.27 1 316351 NPAS2_9350 53.0014 53.0014 14.3825 14.3825 215.15 215.15 53.0014 14.3825 215.15 0 Hill,1(0.5);Linear,1(0.5) 2.900165231863057 5.825700521469116 2.6413023471832275 3.1843981742858887 0.38402674217840843 2.912850260734558 -31.628167999999988 313.94256799999994 -67.66749999999999 267.37 174.7724 339.64759999999995 CONFLICT 0.5 0.5 0.0 GO:0006950 3 response to stress 773 821 58 58 47 40 30 30 39 791 1687 0.9828 0.031065 0.04981 3.65 360243;94195;287877;361042;24614;338475;313108;29685;312538;59107;24539;170496;288001;293502;64194;25663;360504;24426;300850;116686;24404;29739;25283;25317;25426;24296;54232;25612;24207;25748 top2a;s100a9;pycr1;pck2;orm1;nrep;mms22l;mcm6;mcm2;ltbp1;lpl;lcn2;kng1;kif22;insig1;il1r1;hba-a2;gstp1;gsta4;gsr;gpx1;gclm;gclc;fgf1;cyp1b1;cyp1a1;car3;asns;apoc3;alas2 TOP2A_10059;S100A9_9775;PYCR1_9631;PCK2_9440;ORM1_9400;NREP_9364;MMS22L_33129;MCM6_9210;MCM2_9206;LTBP1_33264;LPL_32544;LCN2_32481;KNG1L1_32433;KIF22_8963;INSIG1_8906;IL1R1_8893;HBA2_32600;GSTP1_8762;GSTA4_8757;GSR_8755;GPX1_33050;GCLM_8700;GCLC_8699;FGF1_8633;CYP1B1_32710;CYP1A1_8415;CAR3_8196;ASNS_8091;APOC3_32553;ALAS2_8019 288001(0.1788) 228.61842953333354 102.77664999999999 4.48597E-12 318.84544488305534 168.84329306064038 264.07729232149 146.19451970000014 66.1247 4.48597E-12 210.22768673850652 107.78717147911267 168.29583111498442 580.4416970000001 200.858 4.48599E-12 1014.7402586406545 419.9270387062494 860.489119791767 4.48597E-12;963.318;132.668;6.67763;662.49;191.159;4.13516;1.87441;3.76863;769.394;900.118;972.626;3.87556;0.961856;37.6554;76.6218;131.05;122.514;339.498;69.5519;8.00432;190.233;145.958;674.162;229.313;83.0393;3.44933;6.05608;2.87451;125.506 4.48597E-12;802.143;90.3184;1.48195;432.445;115.886;1.24709;0.496857;0.956203;438.027;487.466;551.931;1.25511;0.281971;13.2791;27.5215;88.5948;84.8469;260.156;41.1016;2.69961;69.2223;96.7058;437.622;185.32;63.0271;2.13143;2.7438;1.13737;85.7907 4.48599E-12;1158.68;239.858;37.9425;1413.32;448.068;20.8956;9.53;22.9217;2211.2;3428.38;4084.57;13.8374;4.47267;101.065;185.143;254.163;216.573;486.944;124.212;25.2254;496.452;280.185;1465.0;299.27;119.986;6.02113;14.3351;8.23841;236.762 22 8 22 360243;94195;287877;361042;24614;313108;29685;312538;170496;288001;293502;64194;25663;24426;300850;116686;29739;25283;25317;25426;24296;25612 TOP2A_10059;S100A9_9775;PYCR1_9631;PCK2_9440;ORM1_9400;MMS22L_33129;MCM6_9210;MCM2_9206;LCN2_32481;KNG1L1_32433;KIF22_8963;INSIG1_8906;IL1R1_8893;GSTP1_8762;GSTA4_8757;GSR_8755;GCLM_8700;GCLC_8699;FGF1_8633;CYP1B1_32710;CYP1A1_8415;ASNS_8091 214.86353300000022 79.83054999999999 310.821559506414 143.82284913636386 52.06435 219.2679451163223 490.69058954545477 154.6775 918.2322034890102 4.48597E-12;963.318;132.668;6.67763;662.49;4.13516;1.87441;3.76863;972.626;3.87556;0.961856;37.6554;76.6218;122.514;339.498;69.5519;190.233;145.958;674.162;229.313;83.0393;6.05608 4.48597E-12;802.143;90.3184;1.48195;432.445;1.24709;0.496857;0.956203;551.931;1.25511;0.281971;13.2791;27.5215;84.8469;260.156;41.1016;69.2223;96.7058;437.622;185.32;63.0271;2.7438 4.48599E-12;1158.68;239.858;37.9425;1413.32;20.8956;9.53;22.9217;4084.57;13.8374;4.47267;101.065;185.143;216.573;486.944;124.212;496.452;280.185;1465.0;299.27;119.986;14.3351 8 338475;59107;24539;360504;24404;54232;24207;25748 NREP_9364;LTBP1_33264;LPL_32544;HBA2_32600;GPX1_33050;CAR3_8196;APOC3_32553;ALAS2_8019 266.444395 128.27800000000002 359.3228686980005 152.71661375000002 87.19275 196.9639608989096 827.2572425 245.4625 1281.211422069995 191.159;769.394;900.118;131.05;8.00432;3.44933;2.87451;125.506 115.886;438.027;487.466;88.5948;2.69961;2.13143;1.13737;85.7907 448.068;2211.2;3428.38;254.163;25.2254;6.02113;8.23841;236.762 0 Exp 2,2(0.07);Exp 4,6(0.2);Exp 5,1(0.04);Hill,8(0.27);Linear,5(0.17);Poly 2,8(0.27) 2.0662948109997727 69.10022616386414 1.5140434503555298 6.759152412414551 1.3995195514814702 1.7625030279159546 114.52105242012335 342.71580664654357 70.96550815731118 221.42353124268917 217.32155895147292 943.5618350485272 UP 0.7333333333333333 0.26666666666666666 0.0 GO:1901388 7 regulation of transforming growth factor beta activation 1 1 1 1 1 1 1 1 68 0 2478 1.0 0.027091 0.027091 100.0 59107 ltbp1 LTBP1_33264 769.394 769.394 769.394 769.394 438.027 438.027 438.027 438.02699999999993 2211.2 2211.2 2211.2 2211.2 0.0 769.394 0.0 769.394 769.394 438.027 2211.2 0 1 0 1 59107 LTBP1_33264 769.394 769.394 438.027 438.027 2211.2 2211.2 769.394 438.027 2211.2 0 Exp 2,1(1) 1.5140434503555298 1.5140434503555298 1.5140434503555298 1.5140434503555298 0.0 1.5140434503555298 769.394 769.394 438.027 438.027 2211.2 2211.2 DOWN 0.0 1.0 0.0 GO:0071371 6 cellular response to gonadotropin stimulus 23 25 7 7 7 4 4 4 65 21 2457 0.99956 0.0040611 0.0040611 16.0 29200;29739;25283;25426 inhba;gclm;gclc;cyp1b1 INHBA_33300;GCLM_8700;GCLC_8699;CYP1B1_32710 164.3286 168.09550000000002 91.8104 59.13368599571657 180.22753983518749 58.86205324477978 98.85187499999999 82.96405 44.1594 61.51021816258797 118.21013335393489 67.3018701970384 315.70925 289.72749999999996 186.93 130.10797847269015 317.762221961269 116.29482266879906 0.5 118.88419999999999 1.5 168.09550000000002 91.8104;190.233;145.958;229.313 44.1594;69.2223;96.7058;185.32 186.93;496.452;280.185;299.27 3 1 3 29739;25283;25426 GCLM_8700;GCLC_8699;CYP1B1_32710 188.50133333333335 190.233 41.70447228215851 117.0827 96.7058 60.671925357038056 358.6356666666666 299.27 119.73331034567353 190.233;145.958;229.313 69.2223;96.7058;185.32 496.452;280.185;299.27 1 29200 INHBA_33300 91.8104 91.8104 44.1594 44.1594 186.93 186.93 91.8104 44.1594 186.93 0 Hill,2(0.5);Linear,1(0.25);Poly 2,1(0.25) 2.2254800245157424 9.146039962768555 1.7603585720062256 3.1843981742858887 0.6392039225261663 2.10064160823822 106.37758772419781 222.27961227580218 38.571861200663804 159.1318887993362 188.20343109676367 443.21506890323633 UP 0.75 0.25 0.0 GO:0010639 7 negative regulation of organelle organization 85 89 9 9 9 5 5 5 64 84 2394 0.9685 0.090873 0.090873 5.62 360243;312538;64194;24404;25283 top2a;mcm2;insig1;gpx1;gclc TOP2A_10059;MCM2_9206;INSIG1_8906;GPX1_33050;GCLC_8699 39.077270000000894 8.00432 4.48597E-12 61.572667374888134 38.35067035089825 60.33929562551698 22.728142600000897 2.69961 4.48597E-12 41.6944424910246 22.061253759385604 40.868530994142574 85.87942000000089 25.2254 4.48599E-12 115.11203204744415 84.57743731680343 113.12622934842618 3.5 91.8067 4.48597E-12;3.76863;37.6554;8.00432;145.958 4.48597E-12;0.956203;13.2791;2.69961;96.7058 4.48599E-12;22.9217;101.065;25.2254;280.185 4 1 4 360243;312538;64194;25283 TOP2A_10059;MCM2_9206;INSIG1_8906;GCLC_8699 46.84550750000112 20.712015 68.21012435483523 27.735275750001122 7.1176515 46.376281620791204 101.04292500000112 61.99335 127.0229401993548 4.48597E-12;3.76863;37.6554;145.958 4.48597E-12;0.956203;13.2791;96.7058 4.48599E-12;22.9217;101.065;280.185 1 24404 GPX1_33050 8.00432 8.00432 2.69961 2.69961 25.2254 25.2254 8.00432 2.69961 25.2254 0 Exp 5,1(0.2);Hill,3(0.6);Poly 2,1(0.2) 1.7528808166349679 8.792539477348328 1.5280487537384033 1.9665359258651733 0.15580760677244052 1.7603585720062256 -14.893552564042587 93.04809256404437 -13.818647616002682 59.27493281600448 -15.020724844997119 186.7795648449989 UP 0.8 0.2 0.0 GO:0016999 5 antibiotic metabolic process 46 51 10 10 8 8 6 6 63 45 2433 0.99965 0.0021853 0.0021853 11.76 361042;287167;360504;84029;24404;24296 pck2;hba-a1;hba-a2;hao2;gpx1;cyp1a1 PCK2_9440;LOC287167_9118;HBA2_32600;HAO2_8778;GPX1_33050;CYP1A1_8415 86.484875 107.04465 6.67763 65.46146097204912 78.23055401594806 64.89776375555145 57.721293333333335 75.81095 1.48195 44.71300292384382 52.51022458236304 44.569693734474065 175.73231666666666 187.0745 25.2254 132.27581553648298 158.3366131253969 130.89595496941985 1.5 45.52181 4.5 145.06900000000002 6.67763;149.282;131.05;140.856;8.00432;83.0393 1.48195;97.0024;88.5948;93.5219;2.69961;63.0271 37.9425;334.152;254.163;282.925;25.2254;119.986 2 4 2 361042;24296 PCK2_9440;CYP1A1_8415 44.858464999999995 44.858464999999995 53.995854679729355 32.254525 32.254525 43.51899291414324 78.96425 78.96425 58.0135152022785 6.67763;83.0393 1.48195;63.0271 37.9425;119.986 4 287167;360504;84029;24404 LOC287167_9118;HBA2_32600;HAO2_8778;GPX1_33050 107.29808 135.953 66.613782387523 70.4546775 91.05835 45.301550893415246 224.11635 268.544 136.6585925507674 149.282;131.05;140.856;8.00432 97.0024;88.5948;93.5219;2.69961 334.152;254.163;282.925;25.2254 0 Hill,2(0.34);Poly 2,4(0.67) 2.232089831868661 15.418325424194336 1.528982162475586 6.292444229125977 1.8346106113582155 1.8663347959518433 34.10479711511235 138.86495288488766 21.943439603210024 93.49914706345663 69.88962056420105 281.5750127691323 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0044281 3 small molecule metabolic process 449 498 44 44 38 33 27 27 42 471 2007 0.99996 1.0774E-4 1.4773E-4 5.42 83472;266730;287877;293820;58835;361042;680308;24552;24539;116682;64194;84029;24426;24404;29739;25283;25315;171142;25426;24296;290277;54232;81508;25612;24207;360887;296925 ugdh;slc17a3;pycr1;psat1;phgdh;pck2;mthfd2;me1;lpl;kynu;insig1;hao2;gstp1;gpx1;gclm;gclc;ephx1;ehhadh;cyp1b1;cyp1a1;cryl1;car3;bhmt;asns;apoc3;coq8a;aass UGDH_10131;SLC17A3_9840;PYCR1_9631;PSAT1_9583;PHGDH_9470;PCK2_9440;MTHFD2_9261;ME1_9215;LPL_32544;KYNU_8979;INSIG1_8906;HAO2_8778;GSTP1_8762;GPX1_33050;GCLM_8700;GCLC_8699;EPHX1_8567;EHHADH_8534;CYP1B1_32710;CYP1A1_8415;CRYL1_8388;CAR3_8196;BHMT_8143;ASNS_8091;APOC3_32553;ADCK3_7987;AASS_7936 141.1823085185185 83.0393 2.87451 212.53256647650065 111.94586635553183 169.76282895788265 86.4258037037037 63.0271 1.13737 127.76229203480277 70.19868288203568 102.91618453158384 342.10292 135.068 6.02113 683.796272870601 255.86260486319023 548.8768933444259 23.5 377.1925 59.3662;93.3839;132.668;27.1579;122.826;6.67763;622.58;13.1175;900.118;100.381;37.6554;140.856;122.514;8.00432;190.233;145.958;27.5708;166.899;229.313;83.0393;32.8011;3.44933;5.5396;6.05608;2.87451;525.072;5.81076 25.4417;68.9252;90.3184;10.0144;67.6778;1.48195;414.266;6.20444;487.466;72.7231;13.2791;93.5219;84.8469;2.69961;69.2223;96.7058;12.6303;105.26;185.32;63.0271;15.4462;2.13143;1.97501;2.7438;1.13737;336.426;2.60489 135.068;143.418;239.858;103.876;246.456;37.9425;1250.29;28.4614;3428.38;161.456;101.065;282.925;216.573;25.2254;496.452;280.185;61.9858;384.658;299.27;119.986;74.622;6.02113;37.8319;14.3351;8.23841;1038.12;14.0792 17 10 17 83472;266730;287877;293820;58835;361042;680308;24552;64194;24426;29739;25283;25315;25426;24296;290277;25612 UGDH_10131;SLC17A3_9840;PYCR1_9631;PSAT1_9583;PHGDH_9470;PCK2_9440;MTHFD2_9261;ME1_9215;INSIG1_8906;GSTP1_8762;GCLM_8700;GCLC_8699;EPHX1_8567;CYP1B1_32710;CYP1A1_8415;CRYL1_8388;ASNS_8091 114.87751823529412 83.0393 146.71790431021185 72.20890529411766 63.0271 100.46561684500686 226.46139999999997 135.068 291.2441044840586 59.3662;93.3839;132.668;27.1579;122.826;6.67763;622.58;13.1175;37.6554;122.514;190.233;145.958;27.5708;229.313;83.0393;32.8011;6.05608 25.4417;68.9252;90.3184;10.0144;67.6778;1.48195;414.266;6.20444;13.2791;84.8469;69.2223;96.7058;12.6303;185.32;63.0271;15.4462;2.7438 135.068;143.418;239.858;103.876;246.456;37.9425;1250.29;28.4614;101.065;216.573;496.452;280.185;61.9858;299.27;119.986;74.622;14.3351 10 24539;116682;84029;24404;171142;54232;81508;24207;360887;296925 LPL_32544;KYNU_8979;HAO2_8778;GPX1_33050;EHHADH_8534;CAR3_8196;BHMT_8143;APOC3_32553;ADCK3_7987;AASS_7936 185.900452 54.192660000000004 297.81499749410915 110.594531 37.711355 167.87314159773757 538.6935040000001 99.64394999999999 1063.8515947854671 900.118;100.381;140.856;8.00432;166.899;3.44933;5.5396;2.87451;525.072;5.81076 487.466;72.7231;93.5219;2.69961;105.26;2.13143;1.97501;1.13737;336.426;2.60489 3428.38;161.456;282.925;25.2254;384.658;6.02113;37.8319;8.23841;1038.12;14.0792 0 Exp 2,2(0.08);Exp 4,5(0.19);Exp 5,1(0.04);Hill,9(0.34);Linear,2(0.08);Poly 2,8(0.3) 2.256523915477805 68.17451882362366 1.5039241313934326 6.759152412414551 1.4545896291023048 1.90879225730896 61.01456200022898 221.35005503680804 38.233589153966776 134.61801825344065 84.17347802103325 600.0323619789668 UP 0.6296296296296297 0.37037037037037035 0.0 GO:0045087 5 innate immune response 79 87 5 5 2 5 2 2 67 85 2393 0.57821 0.69142 1.0 2.3 94195;170496 s100a9;lcn2 S100A9_9775;LCN2_32481 967.972 967.972 963.318 6.581749919279151 969.8503496143959 6.021879893539398 677.037 677.037 551.931 176.92660193424837 626.5443470437019 161.87651610678247 2621.625 2621.625 1158.68 2068.916660005908 3212.068097686376 1892.9263173296083 963.318;972.626 802.143;551.931 1158.68;4084.57 2 0 2 94195;170496 S100A9_9775;LCN2_32481 967.972 967.972 6.581749919279151 677.037 677.037 176.92660193424837 2621.625 2621.625 2068.916660005908 963.318;972.626 802.143;551.931 1158.68;4084.57 0 0 Linear,1(0.5);Poly 2,1(0.5) 1.779702348741393 3.5626214742660522 1.7056305408477783 1.856990933418274 0.10702795998965536 1.7813107371330261 958.85016 977.09384 431.82924 922.24476 -245.74719999999934 5488.9972 UP 1.0 0.0 0.0 GO:0065007 2 biological regulation 1742 1890 103 102 86 60 47 47 22 1843 635 0.15103 0.90302 0.26405 2.49 308843;360243;171497;192247;299270;94195;287877;363465;58835;361042;24614;338475;259241;316351;24567;24552;312538;59107;24539;287598;170496;288001;64194;29200;25663;360504;24426;116686;24404;29739;25283;499709;84586;25317;24890;298452;24309;25426;24296;289185;310395;117517;25612;24207;301111;25748;114628 tsku;top2a;sgk2;sez6;serpina6;s100a9;pycr1;pir;phgdh;pck2;orm1;nrep;nr1d2;npas2;mt1;me1;mcm2;ltbp1;lpl;ska2;lcn2;kng1;insig1;inhba;il1r1;hba-a2;gstp1;gsr;gpx1;gclm;gclc;gar1;fgl2;fgf1;esr1;dph2;dbp;cyp1b1;cyp1a1;creg1;noct;c7;asns;apoc3;ano10;alas2;abcg5 TSKU_10094;TOP2A_10059;SGK2_32380;SEZ6_9819;SERPINA6_32325;S100A9_9775;PYCR1_9631;PIR_9487;PHGDH_9470;PCK2_9440;ORM1_9400;NREP_9364;NR1D2_9358;NPAS2_9350;MT1A_9255;ME1_9215;MCM2_9206;LTBP1_33264;LPL_32544;LOC691962_32591;LCN2_32481;KNG1L1_32433;INSIG1_8906;INHBA_33300;IL1R1_8893;HBA2_32600;GSTP1_8762;GSR_8755;GPX1_33050;GCLM_8700;GCLC_8699;GAR1_8683;FGL2_32918;FGF1_8633;ESR1_33192;DPH2_8490;DBP_8439;CYP1B1_32710;CYP1A1_8415;CREG1_8380;CCRN4L_8232;C7_8179;ASNS_8091;APOC3_32553;ANO10_8049;ALAS2_8019;ABCG5_7947 288001(0.1788);499709(-0.07184) 238.79849702127672 103.858 4.48597E-12 309.5321884635403 194.2639884086492 269.42927640115704 150.59733778723412 56.4566 4.48597E-12 209.1711641182675 120.89619964426772 176.7083024603292 564.0584278723405 239.858 4.48599E-12 867.9850920463314 464.34175809817924 771.8064134091575 92.2997;4.48597E-12;156.37;10.6392;25.7745;963.318;132.668;152.213;122.826;6.67763;662.49;191.159;9.46041;53.0014;818.334;13.1175;3.76863;769.394;900.118;2.47312;972.626;3.87556;37.6554;91.8104;76.6218;131.05;122.514;69.5519;8.00432;190.233;145.958;765.364;146.406;674.162;12.5403;734.134;66.0377;229.313;83.0393;97.6763;665.276;103.858;6.05608;2.87451;9.9207;125.506;565.363 49.0864;4.48597E-12;100.616;3.96047;8.17372;802.143;90.3184;56.4566;67.6778;1.48195;432.445;115.886;2.2133;14.3825;540.216;6.20444;0.956203;438.027;487.466;0.810493;551.931;1.25511;13.2791;44.1594;27.5215;88.5948;84.8469;41.1016;2.69961;69.2223;96.7058;587.034;95.6156;437.622;3.74981;463.289;19.9899;185.32;63.0271;36.7323;433.686;32.7314;2.7438;1.13737;2.9165;85.7907;386.851 185.899;4.48599E-12;343.205;29.4997;103.274;1158.68;239.858;371.778;246.456;37.9425;1413.32;448.068;49.4216;215.15;988.495;28.4614;22.9217;2211.2;3428.38;10.3838;4084.57;13.8374;101.065;186.93;185.143;254.163;216.573;124.212;25.2254;496.452;280.185;1362.21;325.091;1465.0;51.2968;1764.85;280.428;299.27;119.986;282.14;1425.48;293.781;14.3351;8.23841;33.1883;236.762;1047.94 30 17 30 308843;360243;171497;94195;287877;363465;58835;361042;24614;259241;24552;312538;287598;170496;288001;64194;25663;24426;116686;29739;25283;499709;25317;24309;25426;24296;289185;310395;25612;301111 TSKU_10094;TOP2A_10059;SGK2_32380;S100A9_9775;PYCR1_9631;PIR_9487;PHGDH_9470;PCK2_9440;ORM1_9400;NR1D2_9358;ME1_9215;MCM2_9206;LOC691962_32591;LCN2_32481;KNG1L1_32433;INSIG1_8906;IL1R1_8893;GSTP1_8762;GSR_8755;GCLM_8700;GCLC_8699;GAR1_8683;FGF1_8633;DBP_8439;CYP1B1_32710;CYP1A1_8415;CREG1_8380;CCRN4L_8232;ASNS_8091;ANO10_8049 217.78542433333348 94.988 300.5823620646452 142.1781498666668 52.7715 215.389789344072 496.41339333333343 228.21550000000002 825.7583659782355 92.2997;4.48597E-12;156.37;963.318;132.668;152.213;122.826;6.67763;662.49;9.46041;13.1175;3.76863;2.47312;972.626;3.87556;37.6554;76.6218;122.514;69.5519;190.233;145.958;765.364;674.162;66.0377;229.313;83.0393;97.6763;665.276;6.05608;9.9207 49.0864;4.48597E-12;100.616;802.143;90.3184;56.4566;67.6778;1.48195;432.445;2.2133;6.20444;0.956203;0.810493;551.931;1.25511;13.2791;27.5215;84.8469;41.1016;69.2223;96.7058;587.034;437.622;19.9899;185.32;63.0271;36.7323;433.686;2.7438;2.9165 185.899;4.48599E-12;343.205;1158.68;239.858;371.778;246.456;37.9425;1413.32;49.4216;28.4614;22.9217;10.3838;4084.57;13.8374;101.065;185.143;216.573;124.212;496.452;280.185;1362.21;1465.0;280.428;299.27;119.986;282.14;1425.48;14.3351;33.1883 17 192247;299270;338475;316351;24567;59107;24539;29200;360504;24404;84586;24890;298452;117517;24207;25748;114628 SEZ6_9819;SERPINA6_32325;NREP_9364;NPAS2_9350;MT1A_9255;LTBP1_33264;LPL_32544;INHBA_33300;HBA2_32600;GPX1_33050;FGL2_32918;ESR1_33192;DPH2_8490;C7_8179;APOC3_32553;ALAS2_8019;ABCG5_7947 275.88039 125.506 330.76639554356535 165.4547282352941 85.7907 203.30846567706067 683.4320182352941 254.163 952.0490267686773 10.6392;25.7745;191.159;53.0014;818.334;769.394;900.118;91.8104;131.05;8.00432;146.406;12.5403;734.134;103.858;2.87451;125.506;565.363 3.96047;8.17372;115.886;14.3825;540.216;438.027;487.466;44.1594;88.5948;2.69961;95.6156;3.74981;463.289;32.7314;1.13737;85.7907;386.851 29.4997;103.274;448.068;215.15;988.495;2211.2;3428.38;186.93;254.163;25.2254;325.091;51.2968;1764.85;293.781;8.23841;236.762;1047.94 0 Exp 2,3(0.07);Exp 4,9(0.2);Exp 5,1(0.03);Hill,16(0.35);Linear,7(0.15);Poly 2,11(0.24) 2.023292942786405 101.39082479476929 1.503517508506775 6.292444229125977 0.9737834877410168 1.7846373319625854 150.30467334570102 327.2923206968523 90.79626763883117 210.39840793563707 315.9054972519315 812.21135849275 UP 0.6382978723404256 0.3617021276595745 0.0 GO:0019543 8 propionate catabolic process 2 2 1 1 1 1 1 1 68 1 2477 0.99928 0.053458 0.053458 50.0 361042 pck2 PCK2_9440 6.67763 6.67763 6.67763 6.677629999999999 1.48195 1.48195 1.48195 1.48195 37.9425 37.9425 37.9425 37.9425 0.0 6.67763 0.0 6.67763 6.67763 1.48195 37.9425 1 0 1 361042 PCK2_9440 6.67763 6.67763 1.48195 1.48195 37.9425 37.9425 6.67763 1.48195 37.9425 0 0 Hill,1(1) 1.528982162475586 1.528982162475586 1.528982162475586 1.528982162475586 0.0 1.528982162475586 6.67763 6.67763 1.48195 1.48195 37.9425 37.9425 UP 1.0 0.0 0.0 GO:0046327 8 glycerol biosynthetic process from pyruvate 2 2 1 1 1 1 1 1 68 1 2477 0.99928 0.053458 0.053458 50.0 361042 pck2 PCK2_9440 6.67763 6.67763 6.67763 6.677629999999999 1.48195 1.48195 1.48195 1.48195 37.9425 37.9425 37.9425 37.9425 0.0 6.67763 0.0 6.67763 6.67763 1.48195 37.9425 1 0 1 361042 PCK2_9440 6.67763 6.67763 1.48195 1.48195 37.9425 37.9425 6.67763 1.48195 37.9425 0 0 Hill,1(1) 1.528982162475586 1.528982162475586 1.528982162475586 1.528982162475586 0.0 1.528982162475586 6.67763 6.67763 1.48195 1.48195 37.9425 37.9425 UP 1.0 0.0 0.0 GO:0030224 7 monocyte differentiation 8 8 1 1 1 1 1 1 68 7 2471 0.98177 0.1975 0.1975 12.5 363465 pir PIR_9487 152.213 152.213 152.213 152.213 56.4566 56.4566 56.4566 56.4566 371.778 371.778 371.778 371.778 0.0 152.213 0.0 152.213 152.213 56.4566 371.778 1 0 1 363465 PIR_9487 152.213 152.213 56.4566 56.4566 371.778 371.778 152.213 56.4566 371.778 0 0 Hill,1(1) 2.2021820545196533 2.2021820545196533 2.2021820545196533 2.2021820545196533 0.0 2.2021820545196533 152.213 152.213 56.4566 56.4566 371.778 371.778 UP 1.0 0.0 0.0 GO:0010976 8 positive regulation of neuron projection development 73 77 2 2 2 2 2 2 67 75 2403 0.65288 0.62489 1.0 2.6 192247;94195 sez6;s100a9 SEZ6_9819;S100A9_9775 486.9786 486.9786 10.6392 673.6456397726627 288.4439782805429 612.345046474734 403.051735 403.051735 3.96047 564.4002795876349 236.71354561588737 513.0408259616681 594.0898500000001 594.0898500000001 29.4997 798.45104731226 358.77299009552536 725.7933768252786 10.6392;963.318 3.96047;802.143 29.4997;1158.68 1 1 1 94195 S100A9_9775 963.318 963.318 802.143 802.143 1158.68 1158.68 963.318 802.143 1158.68 1 192247 SEZ6_9819 10.6392 10.6392 3.96047 3.96047 29.4997 29.4997 10.6392 3.96047 29.4997 0 Hill,1(0.5);Poly 2,1(0.5) 2.528290919765773 5.453367710113525 1.7056305408477783 3.747737169265747 1.443987444860343 2.7266838550567627 -446.646624 1420.603824 -379.1671444 1185.2706143999999 -512.5068439999999 1700.6865439999997 CONFLICT 0.5 0.5 0.0 GO:0051171 5 regulation of nitrogen compound metabolic process 917 985 44 44 37 25 19 19 50 966 1512 0.033856 0.9817 0.060022 1.93 360243;299270;94195;363465;259241;316351;288001;64194;29200;24426;24404;25283;25317;24890;298452;24309;25426;289185;310395 top2a;serpina6;s100a9;pir;nr1d2;npas2;kng1;insig1;inhba;gstp1;gpx1;gclc;fgf1;esr1;dph2;dbp;cyp1b1;creg1;noct TOP2A_10059;SERPINA6_32325;S100A9_9775;PIR_9487;NR1D2_9358;NPAS2_9350;KNG1L1_32433;INSIG1_8906;INHBA_33300;GSTP1_8762;GPX1_33050;GCLC_8699;FGF1_8633;ESR1_33192;DPH2_8490;DBP_8439;CYP1B1_32710;CREG1_8380;CCRN4L_8232 288001(0.1788) 215.4065415789476 91.8104 4.48597E-12 300.18845717601477 205.6487684460636 280.726915308741 142.45810789473708 36.7323 4.48597E-12 224.88679944651366 132.94239147394254 195.26399686486909 436.34653684210554 216.573 4.48599E-12 559.6293812344737 441.1460273191941 584.1088732949353 4.48597E-12;25.7745;963.318;152.213;9.46041;53.0014;3.87556;37.6554;91.8104;122.514;8.00432;145.958;674.162;12.5403;734.134;66.0377;229.313;97.6763;665.276 4.48597E-12;8.17372;802.143;56.4566;2.2133;14.3825;1.25511;13.2791;44.1594;84.8469;2.69961;96.7058;437.622;3.74981;463.289;19.9899;185.32;36.7323;433.686 4.48599E-12;103.274;1158.68;371.778;49.4216;215.15;13.8374;101.065;186.93;216.573;25.2254;280.185;1465.0;51.2968;1764.85;280.428;299.27;282.14;1425.48 13 6 13 360243;94195;363465;259241;288001;64194;24426;25283;25317;24309;25426;289185;310395 TOP2A_10059;S100A9_9775;PIR_9487;NR1D2_9358;KNG1L1_32433;INSIG1_8906;GSTP1_8762;GCLC_8699;FGF1_8633;DBP_8439;CYP1B1_32710;CREG1_8380;CCRN4L_8232 243.6507207692311 122.514 313.68842320167875 166.9423084615388 56.4566 244.3932848330473 457.21984615384645 280.428 526.5760146465093 4.48597E-12;963.318;152.213;9.46041;3.87556;37.6554;122.514;145.958;674.162;66.0377;229.313;97.6763;665.276 4.48597E-12;802.143;56.4566;2.2133;1.25511;13.2791;84.8469;96.7058;437.622;19.9899;185.32;36.7323;433.686 4.48599E-12;1158.68;371.778;49.4216;13.8374;101.065;216.573;280.185;1465.0;280.428;299.27;282.14;1425.48 6 299270;316351;29200;24404;24890;298452 SERPINA6_32325;NPAS2_9350;INHBA_33300;GPX1_33050;ESR1_33192;DPH2_8490 154.21082 39.38795 285.79391840579393 89.40900666666666 11.27811 183.80312416535054 391.12103333333334 145.102 677.0534831425052 25.7745;53.0014;91.8104;8.00432;12.5403;734.134 8.17372;14.3825;44.1594;2.69961;3.74981;463.289 103.274;215.15;186.93;25.2254;51.2968;1764.85 0 Exp 4,3(0.16);Exp 5,1(0.06);Hill,8(0.43);Linear,4(0.22);Poly 2,3(0.16) 2.035649756047181 40.8207426071167 1.5704141855239868 5.5128583908081055 0.9101918108656222 1.7846373319625854 80.42534938203363 350.3877337758616 41.33667043440251 243.57954535507167 184.70647786689253 687.9865958173184 UP 0.6842105263157895 0.3157894736842105 0.0 GO:0044248 4 cellular catabolic process 306 344 24 24 22 18 16 16 53 328 2150 0.9917 0.018446 0.029675 4.65 94195;361042;24539;287167;116682;360504;24404;25315;171142;25426;24296;310395;81508;24207;26760;296925 s100a9;pck2;lpl;hba-a1;kynu;hba-a2;gpx1;ephx1;ehhadh;cyp1b1;cyp1a1;noct;bhmt;apoc3;akr7a3;aass S100A9_9775;PCK2_9440;LPL_32544;LOC287167_9118;KYNU_8979;HBA2_32600;GPX1_33050;EPHX1_8567;EHHADH_8534;CYP1B1_32710;CYP1A1_8415;CCRN4L_8232;BHMT_8143;APOC3_32553;AKR7A3_8015;AASS_7936 218.89191375000001 91.71015 2.87451 321.99814478363874 150.98507743976313 241.2737717432524 149.426133125 67.8751 1.13737 228.7803107992921 100.83819953820661 160.88932045668625 490.904825625 140.721 8.23841 884.872143297627 339.72593597886623 688.5734408202499 963.318;6.67763;900.118;149.282;100.381;131.05;8.00432;27.5708;166.899;229.313;83.0393;665.276;5.5396;2.87451;57.1167;5.81076 802.143;1.48195;487.466;97.0024;72.7231;88.5948;2.69961;12.6303;105.26;185.32;63.0271;433.686;1.97501;1.13737;33.0666;2.60489 1158.68;37.9425;3428.38;334.152;161.456;254.163;25.2254;61.9858;384.658;299.27;119.986;1425.48;37.8319;8.23841;102.949;14.0792 7 9 7 94195;361042;25315;25426;24296;310395;26760 S100A9_9775;PCK2_9440;EPHX1_8567;CYP1B1_32710;CYP1A1_8415;CCRN4L_8232;AKR7A3_8015 290.3302042857143 83.0393 375.07318555702005 218.76499285714286 63.0271 298.9094407927932 458.04190000000006 119.986 581.0558550483221 963.318;6.67763;27.5708;229.313;83.0393;665.276;57.1167 802.143;1.48195;12.6303;185.32;63.0271;433.686;33.0666 1158.68;37.9425;61.9858;299.27;119.986;1425.48;102.949 9 24539;287167;116682;360504;24404;171142;81508;24207;296925 LPL_32544;LOC287167_9118;KYNU_8979;HBA2_32600;GPX1_33050;EHHADH_8534;BHMT_8143;APOC3_32553;AASS_7936 163.32879888888888 100.381 284.52885803507615 95.49590888888889 72.7231 153.78311526011908 516.4648788888888 161.456 1101.4641142347934 900.118;149.282;100.381;131.05;8.00432;166.899;5.5396;2.87451;5.81076 487.466;97.0024;72.7231;88.5948;2.69961;105.26;1.97501;1.13737;2.60489 3428.38;334.152;161.456;254.163;25.2254;384.658;37.8319;8.23841;14.0792 0 Exp 2,1(0.07);Exp 4,2(0.13);Hill,5(0.32);Linear,2(0.13);Poly 2,6(0.38) 2.184215136302354 38.946697473526 1.5039241313934326 6.292444229125977 1.4033927489600675 1.7710742950439453 61.11282280601708 376.67100469398304 37.3237808333469 261.5284854166531 57.31747540916291 924.4921758408373 CONFLICT 0.4375 0.5625 0.0 GO:0070849 4 response to epidermal growth factor 25 26 2 2 2 2 2 2 67 24 2454 0.96831 0.15528 0.15528 7.69 25663;24426 il1r1;gstp1 IL1R1_8893;GSTP1_8762 99.5679 99.5679 76.6218 32.45068582356932 86.90536187479297 27.062284952962862 56.184200000000004 56.184200000000004 27.5215 40.53517907423131 40.367022722755884 33.804356946116634 200.858 200.858 185.143 22.224366132693476 192.18586021861543 18.534034456217633 0.5 99.5679 76.6218;122.514 27.5215;84.8469 185.143;216.573 2 0 2 25663;24426 IL1R1_8893;GSTP1_8762 99.5679 99.5679 32.45068582356932 56.184200000000004 56.184200000000004 40.53517907423131 200.858 200.858 22.224366132693476 76.6218;122.514 27.5215;84.8469 185.143;216.573 0 0 Hill,1(0.5);Poly 2,1(0.5) 3.0551899779149934 7.206024646759033 1.6931662559509277 5.5128583908081055 2.700930210602431 3.6030123233795166 54.593543999999994 144.542256 0.005307999999999424 112.36309200000001 170.0566 231.6594 UP 1.0 0.0 0.0 GO:0003008 3 system process 296 309 14 14 12 7 5 5 64 304 2174 0.13911 0.93504 0.26241 1.62 288001;24404;29739;25283;114628 kng1;gpx1;gclm;gclc;abcg5 KNG1L1_32433;GPX1_33050;GCLM_8700;GCLC_8699;ABCG5_7947 288001(0.1788) 182.686776 145.958 3.87556 229.31117084630068 243.02232245393108 262.195208211191 111.34676399999998 69.2223 1.25511 159.54293207537881 154.69350006329321 184.74511745329318 372.72796 280.185 13.8374 427.0080794739463 479.41579092797093 479.1927564980097 3.87556;8.00432;190.233;145.958;565.363 1.25511;2.69961;69.2223;96.7058;386.851 13.8374;25.2254;496.452;280.185;1047.94 3 2 3 288001;29739;25283 KNG1L1_32433;GCLM_8700;GCLC_8699 113.35552 145.958 97.3625448386144 55.727736666666665 69.2223 49.135384246355834 263.49146666666667 280.185 241.7399813325328 3.87556;190.233;145.958 1.25511;69.2223;96.7058 13.8374;496.452;280.185 2 24404;114628 GPX1_33050;ABCG5_7947 286.68366000000003 286.68366000000003 394.11210218118305 194.775305 194.775305 271.6360528712381 536.5827 536.5827 723.1684288784876 8.00432;565.363 2.69961;386.851 25.2254;1047.94 0 Exp 4,1(0.2);Hill,2(0.4);Linear,1(0.2);Poly 2,1(0.2) 1.7592516008143386 8.812936663627625 1.5755720138549805 1.90879225730896 0.11966862993837146 1.783576488494873 -18.313327476859314 383.6868794768593 -28.49878184846999 251.19230984846996 -1.5611243169875024 747.0170443169876 UP 0.6 0.4 0.0 GO:0048609 3 multicellular organismal reproductive process 128 145 9 9 9 6 6 6 63 139 2339 0.90571 0.19638 0.2839 4.14 25663;116686;24890;25426;24296;25748 il1r1;gsr;esr1;cyp1b1;cyp1a1;alas2 IL1R1_8893;GSR_8755;ESR1_33192;CYP1B1_32710;CYP1A1_8415;ALAS2_8019 99.42871666666667 79.83054999999999 12.5403 73.18598406054032 108.39791571031755 82.39865017068591 67.751785 52.06435 3.74981 64.17939120407539 78.01317439253272 72.10067689767794 169.44496666666666 154.6775 51.2968 89.53630598950724 170.5349088611396 96.26257658096281 76.6218;69.5519;12.5403;229.313;83.0393;125.506 27.5215;41.1016;3.74981;185.32;63.0271;85.7907 185.143;124.212;51.2968;299.27;119.986;236.762 4 2 4 25663;116686;25426;24296 IL1R1_8893;GSR_8755;CYP1B1_32710;CYP1A1_8415 114.63149999999999 79.83054999999999 76.65250848980742 79.24255 52.06435 72.2153383919926 182.15275 154.6775 83.56081050897404 76.6218;69.5519;229.313;83.0393 27.5215;41.1016;185.32;63.0271 185.143;124.212;299.27;119.986 2 24890;25748 ESR1_33192;ALAS2_8019 69.02315 69.02315 79.87881251148518 44.770255 44.770255 58.01166965357962 144.0294 144.0294 131.14370059411925 12.5403;125.506 3.74981;85.7907 51.2968;236.762 0 Exp 4,1(0.17);Hill,2(0.34);Linear,1(0.17);Poly 2,2(0.34) 2.3919686441077626 16.473087310791016 1.6931662559509277 6.292444229125977 1.830439993210937 1.7856082916259766 40.86773302454964 157.98970030878368 16.397576585532477 119.10599341446752 97.80100071152197 241.08893262181135 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0042221 3 response to chemical 909 981 69 69 56 46 34 34 35 947 1531 0.97547 0.042461 0.078371 3.47 360243;94195;287877;361042;24614;316351;24567;24552;312538;59107;24539;170496;116682;64194;29200;25663;360504;24426;300850;116686;24404;29739;25283;24890;25315;25426;24296;310395;54232;81508;25612;24207;25748;114628 top2a;s100a9;pycr1;pck2;orm1;npas2;mt1;me1;mcm2;ltbp1;lpl;lcn2;kynu;insig1;inhba;il1r1;hba-a2;gstp1;gsta4;gsr;gpx1;gclm;gclc;esr1;ephx1;cyp1b1;cyp1a1;noct;car3;bhmt;asns;apoc3;alas2;abcg5 TOP2A_10059;S100A9_9775;PYCR1_9631;PCK2_9440;ORM1_9400;NPAS2_9350;MT1A_9255;ME1_9215;MCM2_9206;LTBP1_33264;LPL_32544;LCN2_32481;KYNU_8979;INSIG1_8906;INHBA_33300;IL1R1_8893;HBA2_32600;GSTP1_8762;GSTA4_8757;GSR_8755;GPX1_33050;GCLM_8700;GCLC_8699;ESR1_33192;EPHX1_8567;CYP1B1_32710;CYP1A1_8415;CCRN4L_8232;CAR3_8196;BHMT_8143;ASNS_8091;APOC3_32553;ALAS2_8019;ABCG5_7947 245.15643823529422 96.0957 4.48597E-12 322.6784076713617 189.92123828361767 269.849493517807 157.22423891176484 66.1247 4.48597E-12 214.24173853306436 122.29420534291187 174.85835835867448 578.1315923529413 201.04000000000002 4.48599E-12 961.062613763236 444.2523128967409 831.4899938599336 4.48597E-12;963.318;132.668;6.67763;662.49;53.0014;818.334;13.1175;3.76863;769.394;900.118;972.626;100.381;37.6554;91.8104;76.6218;131.05;122.514;339.498;69.5519;8.00432;190.233;145.958;12.5403;27.5708;229.313;83.0393;665.276;3.44933;5.5396;6.05608;2.87451;125.506;565.363 4.48597E-12;802.143;90.3184;1.48195;432.445;14.3825;540.216;6.20444;0.956203;438.027;487.466;551.931;72.7231;13.2791;44.1594;27.5215;88.5948;84.8469;260.156;41.1016;2.69961;69.2223;96.7058;3.74981;12.6303;185.32;63.0271;433.686;2.13143;1.97501;2.7438;1.13737;85.7907;386.851 4.48599E-12;1158.68;239.858;37.9425;1413.32;215.15;988.495;28.4614;22.9217;2211.2;3428.38;4084.57;161.456;101.065;186.93;185.143;254.163;216.573;486.944;124.212;25.2254;496.452;280.185;51.2968;61.9858;299.27;119.986;1425.48;6.02113;37.8319;14.3351;8.23841;236.762;1047.94 20 14 20 360243;94195;287877;361042;24614;24552;312538;170496;64194;25663;24426;300850;116686;29739;25283;25315;25426;24296;310395;25612 TOP2A_10059;S100A9_9775;PYCR1_9631;PCK2_9440;ORM1_9400;ME1_9215;MCM2_9206;LCN2_32481;INSIG1_8906;IL1R1_8893;GSTP1_8762;GSTA4_8757;GSR_8755;GCLM_8700;GCLC_8699;EPHX1_8567;CYP1B1_32710;CYP1A1_8415;CCRN4L_8232;ASNS_8091 237.39765200000025 102.77664999999999 316.7525034986502 158.7860196500002 66.1247 224.45517933062862 539.8692250000001 200.858 947.6775924762692 4.48597E-12;963.318;132.668;6.67763;662.49;13.1175;3.76863;972.626;37.6554;76.6218;122.514;339.498;69.5519;190.233;145.958;27.5708;229.313;83.0393;665.276;6.05608 4.48597E-12;802.143;90.3184;1.48195;432.445;6.20444;0.956203;551.931;13.2791;27.5215;84.8469;260.156;41.1016;69.2223;96.7058;12.6303;185.32;63.0271;433.686;2.7438 4.48599E-12;1158.68;239.858;37.9425;1413.32;28.4614;22.9217;4084.57;101.065;185.143;216.573;486.944;124.212;496.452;280.185;61.9858;299.27;119.986;1425.48;14.3351 14 316351;24567;59107;24539;116682;29200;360504;24404;24890;54232;81508;24207;25748;114628 NPAS2_9350;MT1A_9255;LTBP1_33264;LPL_32544;KYNU_8979;INHBA_33300;HBA2_32600;GPX1_33050;ESR1_33192;CAR3_8196;BHMT_8143;APOC3_32553;ALAS2_8019;ABCG5_7947 256.24041857142856 96.0957 342.70080544819814 154.99312357142858 58.44125 207.05691283758497 632.7921171428571 201.04000000000002 1013.1934247288415 53.0014;818.334;769.394;900.118;100.381;91.8104;131.05;8.00432;12.5403;3.44933;5.5396;2.87451;125.506;565.363 14.3825;540.216;438.027;487.466;72.7231;44.1594;88.5948;2.69961;3.74981;2.13143;1.97501;1.13737;85.7907;386.851 215.15;988.495;2211.2;3428.38;161.456;186.93;254.163;25.2254;51.2968;6.02113;37.8319;8.23841;236.762;1047.94 0 Exp 2,2(0.06);Exp 4,5(0.15);Exp 5,1(0.03);Hill,11(0.33);Linear,6(0.18);Poly 2,9(0.27) 2.148817723899012 80.53422141075134 1.5140434503555298 6.759152412414551 1.3234599207265145 1.7841069102287292 136.692213106809 353.6206633637796 85.2096150394568 229.23886278407286 255.08267050517878 901.1805142007038 CONFLICT 0.5882352941176471 0.4117647058823529 0.0 GO:0002697 5 regulation of immune effector process 103 117 4 4 4 2 2 2 67 115 2363 0.37714 0.8354 0.76909 1.71 25663;84586 il1r1;fgl2 IL1R1_8893;FGL2_32918 111.5139 111.5139 76.6218 49.34488103967826 89.82258411214953 38.650885047136725 61.56855 61.56855 27.5215 48.14979986879488 40.40257499134649 37.714801222744235 255.11700000000002 255.11700000000002 185.143 98.95817981349492 211.6163755624784 77.51201648190676 76.6218;146.406 27.5215;95.6156 185.143;325.091 1 1 1 25663 IL1R1_8893 76.6218 76.6218 27.5215 27.5215 185.143 185.143 76.6218 27.5215 185.143 1 84586 FGL2_32918 146.406 146.406 95.6156 95.6156 325.091 325.091 146.406 95.6156 325.091 0 Hill,1(0.5);Poly 2,1(0.5) 1.6761746763589096 3.3525198698043823 1.6593536138534546 1.6931662559509277 0.02390914851695699 1.6762599349021912 43.125384 179.90241600000002 -5.163667999999987 128.300768 117.96796000000003 392.26604 CONFLICT 0.5 0.5 0.0 GO:0035229 7 positive regulation of glutamate-cysteine ligase activity 1 1 1 1 1 1 1 1 68 0 2478 1.0 0.027091 0.027091 100.0 29739 gclm GCLM_8700 190.233 190.233 190.233 190.233 69.2223 69.2223 69.2223 69.2223 496.452 496.452 496.452 496.452 0.0 190.233 0.0 190.233 190.233 69.2223 496.452 1 0 1 29739 GCLM_8700 190.233 190.233 69.2223 69.2223 496.452 496.452 190.233 69.2223 496.452 0 0 Hill,1(1) 1.90879225730896 1.90879225730896 1.90879225730896 1.90879225730896 0.0 1.90879225730896 190.233 190.233 69.2223 69.2223 496.452 496.452 UP 1.0 0.0 0.0 GO:0007204 11 positive regulation of cytosolic calcium ion concentration 73 76 3 3 2 3 2 2 67 74 2404 0.66042 0.61768 1.0 2.63 288001;24890 kng1;esr1 KNG1L1_32433;ESR1_33192 288001(0.1788) 8.207930000000001 8.207930000000001 3.87556 6.126896411218324 9.055874105067414 6.008397558680914 2.50246 2.50246 1.25511 1.7640192870260798 2.7465949837284986 1.7299018077451012 32.567099999999996 32.567099999999996 13.8374 26.487795759179367 36.23293156671316 25.975501574155945 3.87556;12.5403 1.25511;3.74981 13.8374;51.2968 1 1 1 288001 KNG1L1_32433 3.87556 3.87556 1.25511 1.25511 13.8374 13.8374 3.87556 1.25511 13.8374 1 24890 ESR1_33192 12.5403 12.5403 3.74981 3.74981 51.2968 51.2968 12.5403 3.74981 51.2968 0 Exp 4,1(0.5);Hill,1(0.5) 1.6518696699423767 3.30743408203125 1.5755720138549805 1.7318620681762695 0.11051375724259738 1.653717041015625 -0.2835151999999965 16.6993752 0.05765400000000076 4.947265999999999 -4.143111999999995 69.277312 CONFLICT 0.5 0.5 0.0 GO:0042311 8 vasodilation 12 13 3 3 3 2 2 2 67 11 2467 0.99552 0.046539 0.046539 15.38 288001;24404 kng1;gpx1 KNG1L1_32433;GPX1_33050 288001(0.1788) 5.93994 5.93994 3.87556 2.919474193891769 6.270978221704524 2.881693418867005 1.97736 1.97736 1.25511 1.0214157454239667 2.0931779965055326 1.00819765342461 19.5314 19.5314 13.8374 8.0525320241524 20.44447396622015 7.948324594807512 0.0 3.87556 0.5 5.93994 3.87556;8.00432 1.25511;2.69961 13.8374;25.2254 1 1 1 288001 KNG1L1_32433 3.87556 3.87556 1.25511 1.25511 13.8374 13.8374 3.87556 1.25511 13.8374 1 24404 GPX1_33050 8.00432 8.00432 2.69961 2.69961 25.2254 25.2254 8.00432 2.69961 25.2254 0 Exp 4,1(0.5);Hill,1(0.5) 1.6768496161317121 3.360209345817566 1.5755720138549805 1.7846373319625854 0.1478315041448102 1.680104672908783 1.893755200000001 9.986124799999999 0.5617500000000002 3.39297 8.371160000000001 30.69164 CONFLICT 0.5 0.5 0.0 GO:0048511 2 rhythmic process 111 122 11 11 9 10 8 8 61 114 2364 0.9951 0.015761 0.015761 6.56 360243;259241;316351;29200;24890;24309;25426;310395 top2a;nr1d2;npas2;inhba;esr1;dbp;cyp1b1;noct TOP2A_10059;NR1D2_9358;NPAS2_9350;INHBA_33300;ESR1_33192;DBP_8439;CYP1B1_32710;CCRN4L_8232 140.92990125000057 59.519549999999995 4.48597E-12 224.28704372082436 147.75295671140603 222.84849525204365 87.93761375000057 17.1862 4.48597E-12 152.66130695487396 96.06856870181095 152.57779225148073 313.49705000000057 201.04000000000002 4.48599E-12 462.94995521749695 314.47640514021407 457.7609301937228 5.5 160.5617 4.48597E-12;9.46041;53.0014;91.8104;12.5403;66.0377;229.313;665.276 4.48597E-12;2.2133;14.3825;44.1594;3.74981;19.9899;185.32;433.686 4.48599E-12;49.4216;215.15;186.93;51.2968;280.428;299.27;1425.48 5 3 5 360243;259241;24309;25426;310395 TOP2A_10059;NR1D2_9358;DBP_8439;CYP1B1_32710;CCRN4L_8232 194.0174220000009 66.0377 279.02208027592815 128.24184000000088 19.9899 187.48446346429006 410.9199200000009 280.428 582.743987048885 4.48597E-12;9.46041;66.0377;229.313;665.276 4.48597E-12;2.2133;19.9899;185.32;433.686 4.48599E-12;49.4216;280.428;299.27;1425.48 3 316351;29200;24890 NPAS2_9350;INHBA_33300;ESR1_33192 52.450700000000005 53.0014 39.637919236130436 20.76390333333333 14.3825 20.94696809490656 151.1256 186.93 87.59813971814702 53.0014;91.8104;12.5403 14.3825;44.1594;3.74981 215.15;186.93;51.2968 0 Exp 4,1(0.13);Hill,5(0.63);Linear,2(0.25) 2.1315381360909815 17.440135955810547 1.7318620681762695 3.1843981742858887 0.5172611322056709 2.0398061275482178 -14.493090506332436 296.3528930063336 -17.851274715140022 193.72650221514112 -7.310901630614069 634.3050016306152 UP 0.625 0.375 0.0 GO:0050767 7 regulation of neurogenesis 202 215 9 9 8 5 4 4 65 211 2267 0.29432 0.84803 0.65787 1.86 192247;94195;338475;25663 sez6;s100a9;nrep;il1r1 SEZ6_9819;S100A9_9775;NREP_9364;IL1R1_8893 310.43449999999996 133.8904 10.6392 441.59903006229536 194.07681449179017 331.0569080957321 237.3777425 71.70375 3.96047 379.58016509133074 136.29351726317887 282.8647401567038 455.347675 316.6055 29.4997 499.69537962691754 330.76247921957054 392.2724299881584 10.6392;963.318;191.159;76.6218 3.96047;802.143;115.886;27.5215 29.4997;1158.68;448.068;185.143 2 2 2 94195;25663 S100A9_9775;IL1R1_8893 519.9698999999999 519.9698999999999 626.9888958723433 414.83225 414.83225 547.7401155028953 671.9115 671.9115 688.394614436008 963.318;76.6218 802.143;27.5215 1158.68;185.143 2 192247;338475 SEZ6_9819;NREP_9364 100.89909999999999 100.89909999999999 127.64677471843935 59.923235 59.923235 79.14330125089836 238.78385 238.78385 295.97248331972514 10.6392;191.159 3.96047;115.886 29.4997;448.068 0 Hill,2(0.5);Poly 2,2(0.5) 2.231494324749325 9.437556982040405 1.6931662559509277 3.747737169265747 0.9666846115247464 1.9983267784118652 -122.33254946104944 743.2015494610495 -134.61081928950412 609.3663042895041 -34.35379703437911 945.0491470343791 CONFLICT 0.5 0.5 0.0 GO:0050793 4 regulation of developmental process 584 616 34 34 28 19 14 14 55 602 1876 0.27136 0.81719 0.56832 2.27 192247;94195;338475;259241;24539;64194;29200;25663;24404;84586;25317;24890;25426;310395 sez6;s100a9;nrep;nr1d2;lpl;insig1;inhba;il1r1;gpx1;fgl2;fgf1;esr1;cyp1b1;noct SEZ6_9819;S100A9_9775;NREP_9364;NR1D2_9358;LPL_32544;INSIG1_8906;INHBA_33300;IL1R1_8893;GPX1_33050;FGL2_32918;FGF1_8633;ESR1_33192;CYP1B1_32710;CCRN4L_8232 286.8917021428571 119.10820000000001 8.00432 351.8836772467855 250.36712706378265 314.8537398996162 189.66584214285714 69.8875 2.2133 250.6714636638425 162.11738002687247 210.3978805838347 655.61075 243.1 25.2254 950.2638314903422 576.0878492438812 859.9191061009343 10.6392;963.318;191.159;9.46041;900.118;37.6554;91.8104;76.6218;8.00432;146.406;674.162;12.5403;229.313;665.276 3.96047;802.143;115.886;2.2133;487.466;13.2791;44.1594;27.5215;2.69961;95.6156;437.622;3.74981;185.32;433.686 29.4997;1158.68;448.068;49.4216;3428.38;101.065;186.93;185.143;25.2254;325.091;1465.0;51.2968;299.27;1425.48 7 7 7 94195;259241;64194;25663;25317;25426;310395 S100A9_9775;NR1D2_9358;INSIG1_8906;IL1R1_8893;FGF1_8633;CYP1B1_32710;CCRN4L_8232 379.4009442857142 229.313 382.40802218322744 271.6835571428572 185.32 300.4520028036583 669.1513714285715 299.27 648.4481166250432 963.318;9.46041;37.6554;76.6218;674.162;229.313;665.276 802.143;2.2133;13.2791;27.5215;437.622;185.32;433.686 1158.68;49.4216;101.065;185.143;1465.0;299.27;1425.48 7 192247;338475;24539;29200;24404;84586;24890 SEZ6_9819;NREP_9364;LPL_32544;INHBA_33300;GPX1_33050;FGL2_32918;ESR1_33192 194.38246 91.8104 319.4945954522005 107.64812714285713 44.1594 173.71684867142085 642.0701285714287 186.93 1239.1893119411022 10.6392;191.159;900.118;91.8104;8.00432;146.406;12.5403 3.96047;115.886;487.466;44.1594;2.69961;95.6156;3.74981 29.4997;448.068;3428.38;186.93;25.2254;325.091;51.2968 0 Exp 2,1(0.08);Exp 5,1(0.08);Hill,6(0.43);Linear,3(0.22);Poly 2,3(0.22) 2.0188895548419126 29.265421152114868 1.5704141855239868 3.747737169265747 0.6380249412735869 1.7710742950439453 102.56375970707143 471.21964457864283 58.35609942888189 320.97558485683237 157.83211417280722 1153.3893858271927 CONFLICT 0.5 0.5 0.0 GO:0031399 7 regulation of protein modification process 444 469 22 22 19 7 5 5 64 464 2014 0.007027 0.99785 0.011514 1.07 29200;24426;25283;25317;24890 inhba;gstp1;gclc;fgf1;esr1 INHBA_33300;GSTP1_8762;GCLC_8699;FGF1_8633;ESR1_33192 209.39694 122.514 12.5403 264.65016364506187 268.33983069853684 313.37751769112396 133.416782 84.8469 3.74981 173.94535648046806 171.13206046999073 206.15574164278152 439.99696000000006 216.573 51.2968 579.0552782545964 577.094191946471 681.8311046426127 91.8104;122.514;145.958;674.162;12.5403 44.1594;84.8469;96.7058;437.622;3.74981 186.93;216.573;280.185;1465.0;51.2968 3 2 3 24426;25283;25317 GSTP1_8762;GCLC_8699;FGF1_8633 314.21133333333336 145.958 311.9467376161087 206.39156666666668 96.7058 200.33919574547394 653.9193333333334 280.185 703.1361941447285 122.514;145.958;674.162 84.8469;96.7058;437.622 216.573;280.185;1465.0 2 29200;24890 INHBA_33300;ESR1_33192 52.17535 52.17535 56.052425255335734 23.954605 23.954605 28.573895113968096 119.1134 119.1134 95.90715547403126 91.8104;12.5403 44.1594;3.74981 186.93;51.2968 0 Hill,2(0.4);Linear,1(0.2);Poly 2,2(0.4) 2.271760915983631 12.867984175682068 1.5704141855239868 5.5128583908081055 1.6654224933305735 1.7603585720062256 -22.579156417386315 441.3730364173864 -19.053045452617994 285.886609452618 -67.56737024367447 947.5612902436746 UP 0.6 0.4 0.0 GO:0019216 6 regulation of lipid metabolic process 132 142 14 14 12 7 5 5 64 137 2341 0.81618 0.33976 0.58889 3.52 259241;64194;25317;24890;24207 nr1d2;insig1;fgf1;esr1;apoc3 NR1D2_9358;INSIG1_8906;FGF1_8633;ESR1_33192;APOC3_32553 147.338524 12.5403 2.87451 294.79829943957674 144.54971272807794 295.3221643128444 91.60031599999999 3.74981 1.13737 193.49193349255785 90.38381505225864 193.51569663103072 335.004362 51.2968 8.23841 632.5427355258284 328.3640008470201 634.0713823338775 9.46041;37.6554;674.162;12.5403;2.87451 2.2133;13.2791;437.622;3.74981;1.13737 49.4216;101.065;1465.0;51.2968;8.23841 3 2 3 259241;64194;25317 NR1D2_9358;INSIG1_8906;FGF1_8633 240.42593666666667 37.6554 375.8909001854102 151.03813333333332 13.2791 248.25057393211267 538.4955333333334 101.065 802.7917882339437 9.46041;37.6554;674.162 2.2133;13.2791;437.622 49.4216;101.065;1465.0 2 24890;24207 ESR1_33192;APOC3_32553 7.707405 7.707405 6.834745654525119 2.44359 2.44359 1.847274039442984 29.767605 29.767605 30.446879555975023 12.5403;2.87451 3.74981;1.13737 51.2968;8.23841 0 Exp 4,1(0.2);Exp 5,1(0.2);Hill,2(0.4);Linear,1(0.2) 1.777414512329878 8.96936023235321 1.5235437154769897 2.177004337310791 0.2754356672150171 1.7318620681762695 -111.06357858170674 405.74062658170675 -78.00284162379324 261.20347362379323 -219.443791681294 889.452515681294 UP 0.6 0.4 0.0 GO:0044270 5 cellular nitrogen compound catabolic process 51 59 5 5 5 3 3 3 66 56 2422 0.92636 0.21343 0.21343 5.08 116682;310395;81508 kynu;noct;bhmt KYNU_8979;CCRN4L_8232;BHMT_8143 257.06553333333335 100.381 5.5396 356.6869238010462 281.646744817744 370.23539570176 169.46137 72.7231 1.97501 231.54333154647253 185.00847738062677 240.57946404806475 541.5893 161.456 37.8319 767.9634149391949 597.9907016055183 794.7798315022133 1.5 382.82849999999996 100.381;665.276;5.5396 72.7231;433.686;1.97501 161.456;1425.48;37.8319 1 2 1 310395 CCRN4L_8232 665.276 665.276 433.686 433.686 1425.48 1425.48 665.276 433.686 1425.48 2 116682;81508 KYNU_8979;BHMT_8143 52.960300000000004 52.960300000000004 67.06299707722582 37.349055 37.349055 50.02645419499617 99.64394999999999 99.64394999999999 87.41543942808387 100.381;5.5396 72.7231;1.97501 161.456;37.8319 0 Exp 4,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 1.7919275107475274 5.387490510940552 1.6724973917007446 1.957481861114502 0.14630547230102545 1.7575112581253052 -146.56371795365567 660.6947846203223 -92.5545754029406 431.4773154029406 -327.44311331213964 1410.62171331214 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0008584 6 male gonad development 41 45 6 6 5 4 3 3 66 42 2436 0.9681 0.1207 0.1207 6.67 29200;24890;25426 inhba;esr1;cyp1b1 INHBA_33300;ESR1_33192;CYP1B1_32710 111.22123333333333 91.8104 12.5403 109.68220550455453 133.6246089521773 118.56015801818089 77.74307 44.1594 3.74981 95.33011403623044 99.8889176273328 102.86326460104335 179.1656 186.93 51.2968 124.16880208039375 198.94566310264386 132.56640131517926 1.5 160.5617 91.8104;12.5403;229.313 44.1594;3.74981;185.32 186.93;51.2968;299.27 1 2 1 25426 CYP1B1_32710 229.313 229.313 185.32 185.32 299.27 299.27 229.313 185.32 299.27 2 29200;24890 INHBA_33300;ESR1_33192 52.17535 52.17535 56.052425255335734 23.954605 23.954605 28.573895113968096 119.1134 119.1134 95.90715547403126 91.8104;12.5403 44.1594;3.74981 186.93;51.2968 0 Hill,2(0.67);Linear,1(0.34) 2.329607554891381 7.208751201629639 1.7318620681762695 3.1843981742858887 0.7325371860124695 2.2924909591674805 -12.89586637846483 235.3383330451315 -30.133109321362937 185.61924932136293 38.65537304010533 319.6758269598946 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0006952 4 defense response 257 279 15 15 11 10 6 6 63 273 2205 0.35509 0.78441 0.69623 2.15 94195;24614;170496;288001;25663;24207 s100a9;orm1;lcn2;kng1;il1r1;apoc3 S100A9_9775;ORM1_9400;LCN2_32481;KNG1L1_32433;IL1R1_8893;APOC3_32553 288001(0.1788) 446.967645 369.5559 2.87451 473.3053209181611 279.90156944065535 441.8123851000669 302.73883 229.98325 1.13737 342.32306553028695 176.91339203943954 294.2285592199341 1143.9648016666667 671.9115 8.23841 1562.4550758644905 849.7823759978502 1575.7627109776197 963.318;662.49;972.626;3.87556;76.6218;2.87451 802.143;432.445;551.931;1.25511;27.5215;1.13737 1158.68;1413.32;4084.57;13.8374;185.143;8.23841 5 1 5 94195;24614;170496;288001;25663 S100A9_9775;ORM1_9400;LCN2_32481;KNG1L1_32433;IL1R1_8893 535.7862719999999 662.49 469.95403471570063 363.059122 432.445 345.2424065643254 1371.11008 1158.68 1632.3663801671278 963.318;662.49;972.626;3.87556;76.6218 802.143;432.445;551.931;1.25511;27.5215 1158.68;1413.32;4084.57;13.8374;185.143 1 24207 APOC3_32553 2.87451 2.87451 1.13737 1.13737 8.23841 8.23841 2.87451 1.13737 8.23841 0 Exp 4,2(0.34);Hill,1(0.17);Linear,2(0.34);Poly 2,1(0.17) 1.6466944227161306 9.90368640422821 1.5235437154769897 1.856990933418274 0.12615599361157556 1.634369134902954 68.24451226071284 825.6907777392873 28.823329673386297 576.6543303266137 -106.25964108393032 2394.1892444172636 UP 0.8333333333333334 0.16666666666666666 0.0 GO:0022414 2 reproductive process 343 368 21 21 19 11 9 9 60 359 2119 0.45063 0.68434 0.86286 2.45 360243;29200;25663;116686;84586;24890;25426;24296;25748 top2a;inhba;il1r1;gsr;fgl2;esr1;cyp1b1;cyp1a1;alas2 TOP2A_10059;INHBA_33300;IL1R1_8893;GSR_8755;FGL2_32918;ESR1_33192;CYP1B1_32710;CYP1A1_8415;ALAS2_8019 92.7543000000005 83.0393 4.48597E-12 69.40009399325331 96.37219245137618 79.53049474393029 60.698412222222714 44.1594 4.48597E-12 57.086029218820485 67.33607929119273 67.52931336485487 169.85453333333382 185.143 4.48599E-12 108.00766845418806 157.1752691334603 103.5872145397816 4.48597E-12;91.8104;76.6218;69.5519;146.406;12.5403;229.313;83.0393;125.506 4.48597E-12;44.1594;27.5215;41.1016;95.6156;3.74981;185.32;63.0271;85.7907 4.48599E-12;186.93;185.143;124.212;325.091;51.2968;299.27;119.986;236.762 5 4 5 360243;25663;116686;25426;24296 TOP2A_10059;IL1R1_8893;GSR_8755;CYP1B1_32710;CYP1A1_8415 91.7052000000009 76.6218 83.8736040228676 63.39404000000089 41.1016 71.88301378213673 145.7222000000009 124.212 108.96206521629293 4.48597E-12;76.6218;69.5519;229.313;83.0393 4.48597E-12;27.5215;41.1016;185.32;63.0271 4.48599E-12;185.143;124.212;299.27;119.986 4 29200;84586;24890;25748 INHBA_33300;FGL2_32918;ESR1_33192;ALAS2_8019 94.065675 108.6582 58.82028190861695 57.3288775 64.97505 42.1113605875583 200.01995 211.846 114.42999012967134 91.8104;146.406;12.5403;125.506 44.1594;95.6156;3.74981;85.7907 186.93;325.091;51.2968;236.762 0 Exp 4,1(0.12);Hill,4(0.45);Linear,1(0.12);Poly 2,3(0.34) 2.208316130641043 22.17789077758789 1.6593536138534546 6.292444229125977 1.5170079810401382 1.7586312294006348 47.41290525774168 138.09569474225933 23.402206465926668 97.99461797851878 99.28952327659762 240.41954339007003 CONFLICT 0.5555555555555556 0.4444444444444444 0.0 GO:0014910 7 regulation of smooth muscle cell migration 45 50 5 5 4 3 2 2 67 48 2430 0.84811 0.39522 0.39522 4.0 24426;25426 gstp1;cyp1b1 GSTP1_8762;CYP1B1_32710 175.9135 175.9135 122.514 75.51829712394202 216.54468268975876 49.00231817947903 135.08345 135.08345 84.8469 71.04521033683413 173.3079734646991 46.09982129681577 257.9215 257.9215 216.573 58.47560948378415 289.38318891932494 37.94365777290403 122.514;229.313 84.8469;185.32 216.573;299.27 2 0 2 24426;25426 GSTP1_8762;CYP1B1_32710 175.9135 175.9135 75.51829712394202 135.08345 135.08345 71.04521033683413 257.9215 257.9215 58.47560948378415 122.514;229.313 84.8469;185.32 216.573;299.27 0 0 Linear,1(0.5);Poly 2,1(0.5) 4.189884985866076 8.697256565093994 3.1843981742858887 5.5128583908081055 1.6464700088259563 4.348628282546997 71.25048000000001 280.57651999999996 36.61981200000001 233.54708799999997 176.87844 338.96455999999995 UP 1.0 0.0 0.0