Gene Ontology Analyses GO Category: BP GO File Creation Date: 07/15/20 Deduplicate Gene Sets: true Data Source: Liver_2,3-Benzofluorene_Male Work Source: Liver_2,3-Benzofluorene_Male_williams_0.05_NOMTC_foldfilter1.5_BMD BMDExpress2 Version: BMDExpress 2.30.0507 BETA Timestamp (Start Time): 02/12/2021 22:59.31 Remove Promiscuous Probes: true Remove BMD > Highest Dose from Category Descriptive Statistics: true Remove BMD with p-Value < Cutoff: 0.1 Remove genes with BMDU/BMDL >: 40.0 Identify conflicting probe sets: 0.5 Category Count: 3073 Total Run Time: 0 seconds GO/Pathway/Gene Set/Gene ID GO Level GO/Pathway/Gene Set/Gene Name All Genes (Expression Data) All Genes (Platform) Input Genes Genes with BMD <= Highest Dose Genes with BMD p-Value >= Genes with BMDU/BMDL <= Genes That Passed All Filters Fisher's A Parameter Fisher's B Parameter Fisher's C Parameter Fisher's D Parameter Fisher's Exact Left P-Value Fisher's Exact Right P-Value Fisher's Exact Two Tail Percentage Entrez Gene IDs Gene Symbols Probe IDs Genes with Conflicting Probesets BMD Mean BMD Median BMD Minimum BMD Standard Deviation BMD wMean BMD wSD BMDL Mean BMDL Median BMDL Minimum BMDL Standard Deviation BMDL wMean BMDL wSD BMDU Mean BMDU Median BMDU Minimum BMDU Standard Deviation BMDU wMean BMDU wSD 5th Percentile Index BMD at 5th Percentile of Total Genes 10th Percentile Index BMD at 10th Percentile of Total Genes BMD List BMDL List BMDU List Probes with Adverse Direction Up Probes with Adverse Direction Down Genes with Adverse Direction Up Genes Up List Genes Up Probes List Genes Up BMD Mean Genes Up BMD Median Genes Up SD Genes Up BMDL Mean Genes Up BMDL Median Genes Up BMDL SD Genes Up BMDU Mean Genes Up BMDU Median Genes Up BMDU SD BMD list (up) BMDL List (up) BMDU List (up) Genes with Adverse Direction Down Genes Down List Genes Down Probes List Genes Down BMD Mean Genes Down BMD Median Genes Down SD Genes Down BMDL Mean Genes Down BMDL Median Genes Down BMDL SD Genes Down BMDU Mean Genes Down BMDU Median Genes Down BMDU SD BMD list (down) BMDL List (down) BMDU List (down) Genes with Adverse Conflict Count Genes Conflict List Genes Conflict Probes List BMD list (Conflict) BMDL list (Conflict) BMDU list (Conflict) Model Counts Mean Fold Change Total Fold Change Min Fold Change Max Fold Change Standard Deviation Fold Change Median Fold Change Lower bound of the 95% confidence interval - BMD Upper bound of the 95% confidence interval - BMD Lower bound of the 95% confidence interval - BMDL Upper bound of the 95% confidence interval - BMDL Lower bound of the 95% confidence interval - BMDU Upper bound of the 95% confidence interval - BMDU Overall Direction Percent Genes With Overall Direction Up Percent Genes With Overall Direction Down Percent Genes With Overall Direction Conflict GO:0000083 7 regulation of transcription involved in G1/S transition of mitotic cell cycle 3 3 1 1 0 0 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:0000096 6 sulfur amino acid metabolic process 12 14 1 1 0 1 0 0 52 14 2481 0.74861 1.0 1.0 0.0 0 0 0 0 0 GO:0000097 6 sulfur amino acid biosynthetic process 4 5 1 1 0 1 0 0 52 5 2490 0.90193 1.0 1.0 0.0 0 0 0 0 0 GO:0000165 8 MAPK cascade 43 45 3 3 1 1 0 0 52 45 2450 0.39202 1.0 1.0 0.0 0 0 0 0 0 GO:0000209 10 protein polyubiquitination 28 29 1 1 0 0 0 0 52 29 2466 0.54796 1.0 1.0 0.0 0 0 0 0 0 GO:0000212 7 meiotic spindle organization 7 7 1 1 0 1 0 0 52 7 2488 0.8654 1.0 1.0 0.0 0 0 0 0 0 GO:0000226 5 microtubule cytoskeleton organization 73 80 2 1 0 1 0 0 52 80 2415 0.18701 1.0 0.40963 0.0 0 0 0 0 0 GO:0000266 7 mitochondrial fission 8 8 1 1 0 0 0 0 52 8 2487 0.84768 1.0 1.0 0.0 0 0 0 0 0 GO:0000272 6 polysaccharide catabolic process 4 4 1 1 0 1 0 0 52 4 2491 0.92076 1.0 1.0 0.0 0 0 0 0 0 GO:0000278 4 mitotic cell cycle 41 47 2 1 0 1 0 0 52 47 2448 0.37589 1.0 1.0 0.0 0 0 0 0 0 GO:0000288 9 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 1 1 1 1 0 0 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:0000289 9 nuclear-transcribed mRNA poly(A) tail shortening 2 2 1 1 0 0 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:0000290 9 deadenylation-dependent decapping of nuclear-transcribed mRNA 3 3 1 1 1 0 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:0000422 6 autophagy of mitochondrion 11 11 1 1 0 1 0 0 52 11 2484 0.79664 1.0 1.0 0.0 0 0 0 0 0 GO:0000423 7 mitophagy 2 2 1 1 0 1 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:0000723 6 telomere maintenance 14 16 1 1 0 1 0 0 52 16 2479 0.71819 1.0 1.0 0.0 0 0 0 0 0 GO:0000724 8 double-strand break repair via homologous recombination 15 15 1 1 0 1 0 0 52 15 2480 0.73325 1.0 1.0 0.0 0 0 0 0 0 GO:0000725 7 recombinational repair 15 15 1 1 0 1 0 0 52 15 2480 0.73325 1.0 1.0 0.0 0 0 0 0 0 GO:0000956 8 nuclear-transcribed mRNA catabolic process 15 16 2 2 1 0 0 0 52 16 2479 0.71819 1.0 1.0 0.0 0 0 0 0 0 GO:0000959 7 mitochondrial RNA metabolic process 9 9 1 1 0 1 0 0 52 9 2486 0.83032 1.0 1.0 0.0 0 0 0 0 0 GO:0001505 4 regulation of neurotransmitter levels 102 115 6 5 1 3 0 0 52 115 2380 0.088259 1.0 0.17097 0.0 0 0 0 0 0 GO:0001542 4 ovulation from ovarian follicle 5 8 1 1 0 1 0 0 52 8 2487 0.84768 1.0 1.0 0.0 0 0 0 0 0 GO:0001544 4 initiation of primordial ovarian follicle growth 1 1 1 1 0 1 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:0001547 4 antral ovarian follicle growth 3 3 1 1 0 1 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:0001556 4 oocyte maturation 5 5 1 1 0 1 0 0 52 5 2490 0.90193 1.0 1.0 0.0 0 0 0 0 0 GO:0001658 6 branching involved in ureteric bud morphogenesis 12 12 1 1 1 0 0 0 52 12 2483 0.7803 1.0 1.0 0.0 0 0 0 0 0 GO:0001667 5 ameboidal-type cell migration 42 44 2 2 0 2 0 0 52 44 2451 0.40034 1.0 1.0 0.0 0 0 0 0 0 GO:0001678 6 cellular glucose homeostasis 56 60 4 4 1 2 0 0 52 60 2435 0.28583 1.0 0.63391 0.0 0 0 0 0 0 GO:0001692 5 histamine metabolic process 1 1 1 1 1 0 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:0001694 6 histamine biosynthetic process 1 1 1 1 1 0 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:0001701 7 in utero embryonic development 63 65 2 2 1 1 0 0 52 65 2430 0.25715 1.0 0.64247 0.0 0 0 0 0 0 GO:0001702 6 gastrulation with mouth forming second 6 7 1 1 0 1 0 0 52 7 2488 0.8654 1.0 1.0 0.0 0 0 0 0 0 GO:0001783 8 B cell apoptotic process 5 6 1 1 1 0 0 0 52 6 2489 0.88348 1.0 1.0 0.0 0 0 0 0 0 GO:0001816 5 cytokine production 29 29 1 1 0 1 0 0 52 29 2466 0.54796 1.0 1.0 0.0 0 0 0 0 0 GO:0001885 6 endothelial cell development 10 10 2 1 0 0 0 0 52 10 2485 0.81331 1.0 1.0 0.0 0 0 0 0 0 GO:0001890 5 placenta development 22 23 1 1 1 0 0 0 52 23 2472 0.62094 1.0 1.0 0.0 0 0 0 0 0 GO:0001894 6 tissue homeostasis 38 39 3 2 0 1 0 0 52 39 2456 0.44459 1.0 1.0 0.0 0 0 0 0 0 GO:0001935 5 endothelial cell proliferation 7 8 1 1 0 1 0 0 52 8 2487 0.84768 1.0 1.0 0.0 0 0 0 0 0 GO:0001959 6 regulation of cytokine-mediated signaling pathway 30 30 1 1 0 1 0 0 52 30 2465 0.53665 1.0 1.0 0.0 0 0 0 0 0 GO:0001960 7 negative regulation of cytokine-mediated signaling pathway 13 13 1 1 0 1 0 0 52 13 2482 0.7643 1.0 1.0 0.0 0 0 0 0 0 GO:0001998 8 angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure 2 2 1 1 0 1 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:0002027 6 regulation of heart rate 12 13 1 1 0 1 0 0 52 13 2482 0.7643 1.0 1.0 0.0 0 0 0 0 0 GO:0002033 8 angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure 1 1 1 1 0 1 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:0002042 9 cell migration involved in sprouting angiogenesis 9 9 1 1 0 1 0 0 52 9 2486 0.83032 1.0 1.0 0.0 0 0 0 0 0 GO:0002053 7 positive regulation of mesenchymal cell proliferation 10 10 1 1 1 0 0 0 52 10 2485 0.81331 1.0 1.0 0.0 0 0 0 0 0 GO:0002062 5 chondrocyte differentiation 9 9 1 1 0 1 0 0 52 9 2486 0.83032 1.0 1.0 0.0 0 0 0 0 0 GO:0002064 5 epithelial cell development 37 38 2 1 0 0 0 0 52 38 2457 0.454 1.0 1.0 0.0 0 0 0 0 0 GO:0002066 6 columnar/cuboidal epithelial cell development 9 9 1 0 0 0 0 0 52 9 2486 0.83032 1.0 1.0 0.0 0 0 0 0 0 GO:0002068 7 glandular epithelial cell development 5 5 1 0 0 0 0 0 52 5 2490 0.90193 1.0 1.0 0.0 0 0 0 0 0 GO:0002082 6 regulation of oxidative phosphorylation 7 8 1 1 1 0 0 0 52 8 2487 0.84768 1.0 1.0 0.0 0 0 0 0 0 GO:0002221 5 pattern recognition receptor signaling pathway 26 28 1 0 0 0 0 0 52 28 2467 0.55952 1.0 1.0 0.0 0 0 0 0 0 GO:0002224 6 toll-like receptor signaling pathway 21 23 1 0 0 0 0 0 52 23 2472 0.62094 1.0 1.0 0.0 0 0 0 0 0 GO:0002263 4 cell activation involved in immune response 42 44 2 1 0 0 0 0 52 44 2451 0.40034 1.0 1.0 0.0 0 0 0 0 0 GO:0002274 4 myeloid leukocyte activation 50 53 1 0 0 0 0 0 52 53 2442 0.33131 1.0 0.62624 0.0 0 0 0 0 0 GO:0002275 5 myeloid cell activation involved in immune response 15 15 1 0 0 0 0 0 52 15 2480 0.73325 1.0 1.0 0.0 0 0 0 0 0 GO:0002281 6 macrophage activation involved in immune response 6 6 1 0 0 0 0 0 52 6 2489 0.88348 1.0 1.0 0.0 0 0 0 0 0 GO:0002285 5 lymphocyte activation involved in immune response 30 32 1 1 0 0 0 0 52 32 2463 0.5147 1.0 1.0 0.0 0 0 0 0 0 GO:0002286 6 T cell activation involved in immune response 19 20 1 1 0 0 0 0 52 20 2475 0.66093 1.0 1.0 0.0 0 0 0 0 0 GO:0002291 7 T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell 4 4 1 1 0 0 0 0 52 4 2491 0.92076 1.0 1.0 0.0 0 0 0 0 0 GO:0002366 4 leukocyte activation involved in immune response 41 43 2 1 0 0 0 0 52 43 2452 0.40883 1.0 1.0 0.0 0 0 0 0 0 GO:0002429 7 immune response-activating cell surface receptor signaling pathway 37 40 1 1 0 1 0 0 52 40 2455 0.43537 1.0 1.0 0.0 0 0 0 0 0 GO:0002430 8 complement receptor mediated signaling pathway 2 2 1 1 0 1 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:0002457 4 T cell antigen processing and presentation 1 1 1 1 0 0 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:0002573 6 myeloid leukocyte differentiation 36 39 2 1 0 1 0 0 52 39 2456 0.44459 1.0 1.0 0.0 0 0 0 0 0 GO:0002685 5 regulation of leukocyte migration 73 76 1 1 0 0 0 0 52 76 2419 0.20362 1.0 0.40479 0.0 0 0 0 0 0 GO:0002687 6 positive regulation of leukocyte migration 57 58 1 1 0 0 0 0 52 58 2437 0.29816 1.0 0.63115 0.0 0 0 0 0 0 GO:0002691 6 regulation of cellular extravasation 15 15 1 1 0 0 0 0 52 15 2480 0.73325 1.0 1.0 0.0 0 0 0 0 0 GO:0002693 7 positive regulation of cellular extravasation 11 11 1 1 0 0 0 0 52 11 2484 0.79664 1.0 1.0 0.0 0 0 0 0 0 GO:0002696 6 positive regulation of leukocyte activation 96 103 1 0 0 0 0 0 52 103 2392 0.11431 1.0 0.27079 0.0 0 0 0 0 0 GO:0002697 5 regulation of immune effector process 103 117 2 1 0 1 0 0 52 117 2378 0.084524 1.0 0.17213 0.0 0 0 0 0 0 GO:0002698 6 negative regulation of immune effector process 40 43 1 1 0 1 0 0 52 43 2452 0.40883 1.0 1.0 0.0 0 0 0 0 0 GO:0002699 6 positive regulation of immune effector process 68 81 1 0 0 0 0 0 52 81 2414 0.18306 1.0 0.41112 0.0 0 0 0 0 0 GO:0002700 6 regulation of production of molecular mediator of immune response 44 48 2 1 0 1 0 0 52 48 2447 0.36808 1.0 0.62471 0.0 0 0 0 0 0 GO:0002701 7 negative regulation of production of molecular mediator of immune response 11 12 1 1 0 1 0 0 52 12 2483 0.7803 1.0 1.0 0.0 0 0 0 0 0 GO:0002702 7 positive regulation of production of molecular mediator of immune response 35 38 1 0 0 0 0 0 52 38 2457 0.454 1.0 1.0 0.0 0 0 0 0 0 GO:0002703 6 regulation of leukocyte mediated immunity 69 79 1 0 0 0 0 0 52 79 2416 0.19103 1.0 0.40824 0.0 0 0 0 0 0 GO:0002705 7 positive regulation of leukocyte mediated immunity 47 57 1 0 0 0 0 0 52 57 2438 0.30452 1.0 0.62993 0.0 0 0 0 0 0 GO:0002718 6 regulation of cytokine production involved in immune response 32 36 2 1 0 1 0 0 52 36 2459 0.47341 1.0 1.0 0.0 0 0 0 0 0 GO:0002719 7 negative regulation of cytokine production involved in immune response 11 12 1 1 0 1 0 0 52 12 2483 0.7803 1.0 1.0 0.0 0 0 0 0 0 GO:0002720 7 positive regulation of cytokine production involved in immune response 22 25 1 0 0 0 0 0 52 25 2470 0.59562 1.0 1.0 0.0 0 0 0 0 0 GO:0002730 7 regulation of dendritic cell cytokine production 4 5 1 0 0 0 0 0 52 5 2490 0.90193 1.0 1.0 0.0 0 0 0 0 0 GO:0002732 8 positive regulation of dendritic cell cytokine production 2 3 1 0 0 0 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:0002733 8 regulation of myeloid dendritic cell cytokine production 2 3 1 0 0 0 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:0002735 9 positive regulation of myeloid dendritic cell cytokine production 2 3 1 0 0 0 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:0002739 7 regulation of cytokine secretion involved in immune response 6 7 1 1 0 1 0 0 52 7 2488 0.8654 1.0 1.0 0.0 0 0 0 0 0 GO:0002740 7 negative regulation of cytokine secretion involved in immune response 3 4 1 1 0 1 0 0 52 4 2491 0.92076 1.0 1.0 0.0 0 0 0 0 0 GO:0002756 7 MyD88-independent toll-like receptor signaling pathway 4 4 1 0 0 0 0 0 52 4 2491 0.92076 1.0 1.0 0.0 0 0 0 0 0 GO:0002757 6 immune response-activating signal transduction 38 41 1 1 0 1 0 0 52 41 2454 0.42634 1.0 1.0 0.0 0 0 0 0 0 GO:0002762 8 negative regulation of myeloid leukocyte differentiation 20 20 1 1 1 0 0 0 52 20 2475 0.66093 1.0 1.0 0.0 0 0 0 0 0 GO:0002764 5 immune response-regulating signaling pathway 45 49 1 1 0 1 0 0 52 49 2446 0.36042 1.0 0.62471 0.0 0 0 0 0 0 GO:0002768 6 immune response-regulating cell surface receptor signaling pathway 43 47 1 1 0 1 0 0 52 47 2448 0.37589 1.0 1.0 0.0 0 0 0 0 0 GO:0002790 6 peptide secretion 29 31 1 1 0 0 0 0 52 31 2464 0.52556 1.0 1.0 0.0 0 0 0 0 0 GO:0002792 7 negative regulation of peptide secretion 35 37 2 2 0 2 0 0 52 37 2458 0.46361 1.0 1.0 0.0 0 0 0 0 0 GO:0002886 7 regulation of myeloid leukocyte mediated immunity 26 28 1 0 0 0 0 0 52 28 2467 0.55952 1.0 1.0 0.0 0 0 0 0 0 GO:0002888 8 positive regulation of myeloid leukocyte mediated immunity 20 22 1 0 0 0 0 0 52 22 2473 0.634 1.0 1.0 0.0 0 0 0 0 0 GO:0002902 10 regulation of B cell apoptotic process 8 10 1 1 1 0 0 0 52 10 2485 0.81331 1.0 1.0 0.0 0 0 0 0 0 GO:0002904 11 positive regulation of B cell apoptotic process 3 3 1 1 1 0 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:0003002 4 regionalization 36 40 1 0 0 1 0 0 52 40 2455 0.43537 1.0 1.0 0.0 0 0 0 0 0 GO:0003009 7 skeletal muscle contraction 14 16 1 1 1 0 0 0 52 16 2479 0.71819 1.0 1.0 0.0 0 0 0 0 0 GO:0003012 4 muscle system process 68 71 1 1 1 0 0 0 52 71 2424 0.22644 1.0 0.40159 0.0 0 0 0 0 0 GO:0003013 4 circulatory system process 81 84 2 2 0 1 0 0 52 84 2411 0.17172 1.0 0.41625 0.0 0 0 0 0 0 GO:0003018 5 vascular process in circulatory system 70 73 2 2 0 1 0 0 52 73 2422 0.21703 1.0 0.40246 0.0 0 0 0 0 0 GO:0003044 6 regulation of systemic arterial blood pressure mediated by a chemical signal 9 12 1 0 0 0 0 0 52 12 2483 0.7803 1.0 1.0 0.0 0 0 0 0 0 GO:0003062 7 regulation of heart rate by chemical signal 1 1 1 1 0 1 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:0003073 5 regulation of systemic arterial blood pressure 15 18 1 0 0 0 0 0 52 18 2477 0.68897 1.0 1.0 0.0 0 0 0 0 0 GO:0003084 6 positive regulation of systemic arterial blood pressure 6 8 1 1 0 1 0 0 52 8 2487 0.84768 1.0 1.0 0.0 0 0 0 0 0 GO:0003085 6 negative regulation of systemic arterial blood pressure 7 8 1 1 0 1 0 0 52 8 2487 0.84768 1.0 1.0 0.0 0 0 0 0 0 GO:0003179 4 heart valve morphogenesis 13 13 1 1 0 0 0 0 52 13 2482 0.7643 1.0 1.0 0.0 0 0 0 0 0 GO:0003180 5 aortic valve morphogenesis 7 7 1 1 0 0 0 0 52 7 2488 0.8654 1.0 1.0 0.0 0 0 0 0 0 GO:0005976 5 polysaccharide metabolic process 20 22 2 2 1 1 0 0 52 22 2473 0.634 1.0 1.0 0.0 0 0 0 0 0 GO:0005977 6 glycogen metabolic process 15 16 1 1 0 1 0 0 52 16 2479 0.71819 1.0 1.0 0.0 0 0 0 0 0 GO:0005980 7 glycogen catabolic process 4 4 1 1 0 1 0 0 52 4 2491 0.92076 1.0 1.0 0.0 0 0 0 0 0 GO:0006006 6 glucose metabolic process 37 43 7 6 2 4 0 0 52 43 2452 0.40883 1.0 1.0 0.0 0 0 0 0 0 GO:0006012 6 galactose metabolic process 5 5 1 1 0 1 0 0 52 5 2490 0.90193 1.0 1.0 0.0 0 0 0 0 0 GO:0006015 7 5-phosphoribose 1-diphosphate biosynthetic process 1 1 1 1 0 1 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:0006022 5 aminoglycan metabolic process 23 24 1 1 0 1 0 0 52 24 2471 0.60815 1.0 1.0 0.0 0 0 0 0 0 GO:0006023 6 aminoglycan biosynthetic process 8 9 1 1 0 1 0 0 52 9 2486 0.83032 1.0 1.0 0.0 0 0 0 0 0 GO:0006024 7 glycosaminoglycan biosynthetic process 6 6 1 1 0 1 0 0 52 6 2489 0.88348 1.0 1.0 0.0 0 0 0 0 0 GO:0006029 6 proteoglycan metabolic process 11 11 1 1 0 1 0 0 52 11 2484 0.79664 1.0 1.0 0.0 0 0 0 0 0 GO:0006065 6 UDP-glucuronate biosynthetic process 1 1 1 1 0 1 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:0006071 6 glycerol metabolic process 6 6 1 1 0 1 0 0 52 6 2489 0.88348 1.0 1.0 0.0 0 0 0 0 0 GO:0006072 6 glycerol-3-phosphate metabolic process 1 1 1 1 0 1 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:0006073 6 cellular glucan metabolic process 15 16 1 1 0 1 0 0 52 16 2479 0.71819 1.0 1.0 0.0 0 0 0 0 0 GO:0006090 8 pyruvate metabolic process 20 25 3 2 0 2 0 0 52 25 2470 0.59562 1.0 1.0 0.0 0 0 0 0 0 GO:0006091 4 generation of precursor metabolites and energy 77 85 4 3 0 3 0 0 52 85 2410 0.1681 1.0 0.41817 0.0 0 0 0 0 0 GO:0006094 7 gluconeogenesis 10 13 3 2 0 2 0 0 52 13 2482 0.7643 1.0 1.0 0.0 0 0 0 0 0 GO:0006096 8 glycolytic process 11 16 1 0 0 0 0 0 52 16 2479 0.71819 1.0 1.0 0.0 0 0 0 0 0 GO:0006098 5 pentose-phosphate shunt 3 3 1 1 0 1 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:0006107 8 oxaloacetate metabolic process 6 6 1 1 0 1 0 0 52 6 2489 0.88348 1.0 1.0 0.0 0 0 0 0 0 GO:0006108 8 malate metabolic process 2 2 1 1 0 1 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:0006110 6 regulation of glycolytic process 22 23 2 2 1 1 0 0 52 23 2472 0.62094 1.0 1.0 0.0 0 0 0 0 0 GO:0006111 7 regulation of gluconeogenesis 17 17 2 1 0 0 0 0 52 17 2478 0.70343 1.0 1.0 0.0 0 0 0 0 0 GO:0006112 5 energy reserve metabolic process 16 17 1 1 0 1 0 0 52 17 2478 0.70343 1.0 1.0 0.0 0 0 0 0 0 GO:0006114 7 glycerol biosynthetic process 3 3 1 1 0 1 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:0006116 4 NADH oxidation 3 3 1 1 0 1 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:0006127 5 glycerophosphate shuttle 1 1 1 1 0 1 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:0006140 6 regulation of nucleotide metabolic process 30 33 3 3 1 2 0 0 52 33 2462 0.50406 1.0 1.0 0.0 0 0 0 0 0 GO:0006164 7 purine nucleotide biosynthetic process 33 38 2 0 0 0 0 0 52 38 2457 0.454 1.0 1.0 0.0 0 0 0 0 0 GO:0006165 7 nucleoside diphosphate phosphorylation 13 18 2 1 0 1 0 0 52 18 2477 0.68897 1.0 1.0 0.0 0 0 0 0 0 GO:0006260 6 DNA replication 28 29 1 1 0 1 0 0 52 29 2466 0.54796 1.0 1.0 0.0 0 0 0 0 0 GO:0006261 7 DNA-dependent DNA replication 13 13 1 1 0 1 0 0 52 13 2482 0.7643 1.0 1.0 0.0 0 0 0 0 0 GO:0006268 10 DNA unwinding involved in DNA replication 5 5 1 1 0 1 0 0 52 5 2490 0.90193 1.0 1.0 0.0 0 0 0 0 0 GO:0006278 7 RNA-dependent DNA biosynthetic process 3 5 1 1 0 1 0 0 52 5 2490 0.90193 1.0 1.0 0.0 0 0 0 0 0 GO:0006281 6 DNA repair 69 74 1 1 0 1 0 0 52 74 2421 0.21247 1.0 0.40311 0.0 0 0 0 0 0 GO:0006284 7 base-excision repair 12 13 1 1 0 1 0 0 52 13 2482 0.7643 1.0 1.0 0.0 0 0 0 0 0 GO:0006289 7 nucleotide-excision repair 8 9 1 1 0 1 0 0 52 9 2486 0.83032 1.0 1.0 0.0 0 0 0 0 0 GO:0006298 7 mismatch repair 6 6 1 1 0 1 0 0 52 6 2489 0.88348 1.0 1.0 0.0 0 0 0 0 0 GO:0006302 7 double-strand break repair 29 31 1 1 0 1 0 0 52 31 2464 0.52556 1.0 1.0 0.0 0 0 0 0 0 GO:0006310 6 DNA recombination 26 28 1 1 0 1 0 0 52 28 2467 0.55952 1.0 1.0 0.0 0 0 0 0 0 GO:0006325 5 chromatin organization 88 101 3 3 1 1 0 0 52 101 2394 0.11933 1.0 0.26809 0.0 0 0 0 0 0 GO:0006338 6 chromatin remodeling 22 24 1 1 1 0 0 0 52 24 2471 0.60815 1.0 1.0 0.0 0 0 0 0 0 GO:0006352 7 DNA-templated transcription, initiation 6 6 1 1 1 0 0 0 52 6 2489 0.88348 1.0 1.0 0.0 0 0 0 0 0 GO:0006390 7 mitochondrial transcription 4 4 1 1 0 1 0 0 52 4 2491 0.92076 1.0 1.0 0.0 0 0 0 0 0 GO:0006401 6 RNA catabolic process 23 25 2 2 1 0 0 0 52 25 2470 0.59562 1.0 1.0 0.0 0 0 0 0 0 GO:0006402 7 mRNA catabolic process 19 21 2 2 1 0 0 0 52 21 2474 0.64733 1.0 1.0 0.0 0 0 0 0 0 GO:0006417 7 regulation of translation 60 67 4 4 0 2 0 0 52 67 2428 0.24648 1.0 0.64646 0.0 0 0 0 0 0 GO:0006470 7 protein dephosphorylation 27 33 1 1 0 0 0 0 52 33 2462 0.50406 1.0 1.0 0.0 0 0 0 0 0 GO:0006473 8 protein acetylation 19 19 1 1 0 1 0 0 52 19 2476 0.67481 1.0 1.0 0.0 0 0 0 0 0 GO:0006475 9 internal protein amino acid acetylation 15 15 1 1 0 1 0 0 52 15 2480 0.73325 1.0 1.0 0.0 0 0 0 0 0 GO:0006479 7 protein methylation 16 19 1 1 0 1 0 0 52 19 2476 0.67481 1.0 1.0 0.0 0 0 0 0 0 GO:0006505 7 GPI anchor metabolic process 5 5 1 1 0 1 0 0 52 5 2490 0.90193 1.0 1.0 0.0 0 0 0 0 0 GO:0006507 8 GPI anchor release 1 1 1 1 0 1 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:0006521 6 regulation of cellular amino acid metabolic process 4 4 1 1 0 1 0 0 52 4 2491 0.92076 1.0 1.0 0.0 0 0 0 0 0 GO:0006536 7 glutamate metabolic process 7 7 1 1 0 1 0 0 52 7 2488 0.8654 1.0 1.0 0.0 0 0 0 0 0 GO:0006544 8 glycine metabolic process 3 3 1 1 0 1 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:0006547 7 histidine metabolic process 2 2 1 1 1 0 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:0006548 7 histidine catabolic process 2 2 1 1 1 0 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:0006555 7 methionine metabolic process 4 4 1 1 0 1 0 0 52 4 2491 0.92076 1.0 1.0 0.0 0 0 0 0 0 GO:0006560 8 proline metabolic process 3 3 2 2 1 1 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:0006561 8 proline biosynthetic process 1 1 1 1 1 0 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:0006562 8 proline catabolic process 2 2 1 1 0 1 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:0006563 9 L-serine metabolic process 3 3 1 1 1 0 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:0006564 9 L-serine biosynthetic process 2 2 1 1 1 0 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:0006576 6 cellular biogenic amine metabolic process 13 15 1 1 1 0 0 0 52 15 2480 0.73325 1.0 1.0 0.0 0 0 0 0 0 GO:0006577 5 amino-acid betaine metabolic process 12 13 2 2 0 2 0 0 52 13 2482 0.7643 1.0 1.0 0.0 0 0 0 0 0 GO:0006578 6 amino-acid betaine biosynthetic process 4 4 1 1 0 1 0 0 52 4 2491 0.92076 1.0 1.0 0.0 0 0 0 0 0 GO:0006579 6 amino-acid betaine catabolic process 3 3 1 1 0 1 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:0006584 6 catecholamine metabolic process 12 14 2 2 1 1 0 0 52 14 2481 0.74861 1.0 1.0 0.0 0 0 0 0 0 GO:0006635 7 fatty acid beta-oxidation 29 33 1 1 0 0 0 0 52 33 2462 0.50406 1.0 1.0 0.0 0 0 0 0 0 GO:0006642 8 triglyceride mobilization 2 2 1 1 0 0 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:0006643 5 membrane lipid metabolic process 25 29 1 1 0 1 0 0 52 29 2466 0.54796 1.0 1.0 0.0 0 0 0 0 0 GO:0006644 5 phospholipid metabolic process 58 63 3 3 0 3 0 0 52 63 2432 0.26826 1.0 0.63879 0.0 0 0 0 0 0 GO:0006650 6 glycerophospholipid metabolic process 42 46 2 2 0 2 0 0 52 46 2449 0.38388 1.0 1.0 0.0 0 0 0 0 0 GO:0006656 6 phosphatidylcholine biosynthetic process 7 7 1 1 0 1 0 0 52 7 2488 0.8654 1.0 1.0 0.0 0 0 0 0 0 GO:0006662 5 glycerol ether metabolic process 2 2 1 0 0 0 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:0006664 6 glycolipid metabolic process 12 13 1 1 0 1 0 0 52 13 2482 0.7643 1.0 1.0 0.0 0 0 0 0 0 GO:0006695 7 cholesterol biosynthetic process 21 21 4 4 0 4 0 0 52 21 2474 0.64733 1.0 1.0 0.0 0 0 0 0 0 GO:0006699 7 bile acid biosynthetic process 6 6 1 1 0 1 0 0 52 6 2489 0.88348 1.0 1.0 0.0 0 0 0 0 0 GO:0006706 6 steroid catabolic process 12 14 2 2 0 2 0 0 52 14 2481 0.74861 1.0 1.0 0.0 0 0 0 0 0 GO:0006707 6 cholesterol catabolic process 4 4 1 1 0 1 0 0 52 4 2491 0.92076 1.0 1.0 0.0 0 0 0 0 0 GO:0006733 6 oxidoreduction coenzyme metabolic process 9 9 1 1 0 1 0 0 52 9 2486 0.83032 1.0 1.0 0.0 0 0 0 0 0 GO:0006734 3 NADH metabolic process 6 8 1 1 0 1 0 0 52 8 2487 0.84768 1.0 1.0 0.0 0 0 0 0 0 GO:0006740 4 NADPH regeneration 4 4 1 1 0 1 0 0 52 4 2491 0.92076 1.0 1.0 0.0 0 0 0 0 0 GO:0006741 8 NADP biosynthetic process 3 3 1 1 0 1 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:0006754 8 ATP biosynthetic process 8 8 1 0 0 0 0 0 52 8 2487 0.84768 1.0 1.0 0.0 0 0 0 0 0 GO:0006757 7 ATP generation from ADP 11 16 1 0 0 0 0 0 52 16 2479 0.71819 1.0 1.0 0.0 0 0 0 0 0 GO:0006779 6 porphyrin-containing compound biosynthetic process 8 8 1 1 1 0 0 0 52 8 2487 0.84768 1.0 1.0 0.0 0 0 0 0 0 GO:0006782 7 protoporphyrinogen IX biosynthetic process 4 4 1 1 1 0 0 0 52 4 2491 0.92076 1.0 1.0 0.0 0 0 0 0 0 GO:0006783 6 heme biosynthetic process 7 7 1 1 1 0 0 0 52 7 2488 0.8654 1.0 1.0 0.0 0 0 0 0 0 GO:0006848 9 pyruvate transport 3 3 1 1 1 0 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:0006865 6 amino acid transport 21 21 1 1 1 0 0 0 52 21 2474 0.64733 1.0 1.0 0.0 0 0 0 0 0 GO:0006879 10 cellular iron ion homeostasis 15 15 1 1 1 0 0 0 52 15 2480 0.73325 1.0 1.0 0.0 0 0 0 0 0 GO:0006882 9 cellular zinc ion homeostasis 2 5 1 1 0 1 0 0 52 5 2490 0.90193 1.0 1.0 0.0 0 0 0 0 0 GO:0006886 5 intracellular protein transport 114 122 1 1 0 1 0 0 52 122 2373 0.075853 1.0 0.17635 0.0 0 0 0 0 0 GO:0006897 5 endocytosis 72 75 1 1 0 1 0 0 52 75 2420 0.208 1.0 0.40388 0.0 0 0 0 0 0 GO:0006914 4 autophagy 36 40 1 1 0 1 0 0 52 40 2455 0.43537 1.0 1.0 0.0 0 0 0 0 0 GO:0006915 5 apoptotic process 137 149 5 5 2 2 0 0 52 149 2346 0.042112 1.0 0.071704 0.0 0 0 0 0 0 GO:0006919 10 activation of cysteine-type endopeptidase activity involved in apoptotic process 32 34 1 1 1 0 0 0 52 34 2461 0.49363 1.0 1.0 0.0 0 0 0 0 0 GO:0006936 5 muscle contraction 49 51 1 1 1 0 0 0 52 51 2444 0.34556 1.0 0.62518 0.0 0 0 0 0 0 GO:0006941 6 striated muscle contraction 34 36 1 1 1 0 0 0 52 36 2459 0.47341 1.0 1.0 0.0 0 0 0 0 0 GO:0006975 7 DNA damage induced protein phosphorylation 4 5 1 0 0 0 0 0 52 5 2490 0.90193 1.0 1.0 0.0 0 0 0 0 0 GO:0006991 4 response to sterol depletion 3 3 1 1 0 1 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:0007004 8 telomere maintenance via telomerase 3 5 1 1 0 1 0 0 52 5 2490 0.90193 1.0 1.0 0.0 0 0 0 0 0 GO:0007005 6 mitochondrion organization 66 71 4 4 1 1 0 0 52 71 2424 0.22644 1.0 0.40159 0.0 0 0 0 0 0 GO:0007006 6 mitochondrial membrane organization 27 28 1 1 1 0 0 0 52 28 2467 0.55952 1.0 1.0 0.0 0 0 0 0 0 GO:0007007 7 inner mitochondrial membrane organization 4 4 1 1 1 0 0 0 52 4 2491 0.92076 1.0 1.0 0.0 0 0 0 0 0 GO:0007017 3 microtubule-based process 97 110 3 2 0 2 0 0 52 110 2385 0.098318 1.0 0.16946 0.0 0 0 0 0 0 GO:0007018 4 microtubule-based movement 28 32 1 1 0 1 0 0 52 32 2463 0.5147 1.0 1.0 0.0 0 0 0 0 0 GO:0007032 7 endosome organization 7 9 1 1 0 1 0 0 52 9 2486 0.83032 1.0 1.0 0.0 0 0 0 0 0 GO:0007049 3 cell cycle 49 56 3 2 0 2 0 0 52 56 2439 0.31101 1.0 0.62883 0.0 0 0 0 0 0 GO:0007051 6 spindle organization 29 29 1 1 0 1 0 0 52 29 2466 0.54796 1.0 1.0 0.0 0 0 0 0 0 GO:0007052 7 mitotic spindle organization 19 19 1 1 0 1 0 0 52 19 2476 0.67481 1.0 1.0 0.0 0 0 0 0 0 GO:0007056 7 spindle assembly involved in female meiosis 1 1 1 1 0 1 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:0007057 8 spindle assembly involved in female meiosis I 1 1 1 1 0 1 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:0007063 7 regulation of sister chromatid cohesion 6 7 1 1 0 0 0 0 52 7 2488 0.8654 1.0 1.0 0.0 0 0 0 0 0 GO:0007088 7 regulation of mitotic nuclear division 43 46 1 1 0 0 0 0 52 46 2449 0.38388 1.0 1.0 0.0 0 0 0 0 0 GO:0007098 4 centrosome cycle 8 9 1 1 0 1 0 0 52 9 2486 0.83032 1.0 1.0 0.0 0 0 0 0 0 GO:0007100 5 mitotic centrosome separation 3 3 1 1 0 1 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:0007155 3 cell adhesion 145 150 1 1 0 0 0 0 52 150 2345 0.041199 1.0 0.071757 0.0 0 0 0 0 0 GO:0007159 5 leukocyte cell-cell adhesion 25 26 1 1 0 0 0 0 52 26 2469 0.58334 1.0 1.0 0.0 0 0 0 0 0 GO:0007162 6 negative regulation of cell adhesion 83 86 1 1 0 1 0 0 52 86 2409 0.16455 1.0 0.42017 0.0 0 0 0 0 0 GO:0007169 7 transmembrane receptor protein tyrosine kinase signaling pathway 107 112 5 5 2 3 0 0 52 112 2383 0.094166 1.0 0.16982 0.0 0 0 0 0 0 GO:0007179 8 transforming growth factor beta receptor signaling pathway 27 29 1 1 0 1 0 0 52 29 2466 0.54796 1.0 1.0 0.0 0 0 0 0 0 GO:0007229 6 integrin-mediated signaling pathway 28 29 2 2 0 1 0 0 52 29 2466 0.54796 1.0 1.0 0.0 0 0 0 0 0 GO:0007263 7 nitric oxide mediated signal transduction 7 9 1 1 0 1 0 0 52 9 2486 0.83032 1.0 1.0 0.0 0 0 0 0 0 GO:0007267 3 cell-cell signaling 69 71 1 1 1 0 0 0 52 71 2424 0.22644 1.0 0.40159 0.0 0 0 0 0 0 GO:0007268 7 chemical synaptic transmission 38 38 1 1 1 0 0 0 52 38 2457 0.454 1.0 1.0 0.0 0 0 0 0 0 GO:0007274 8 neuromuscular synaptic transmission 6 6 1 1 1 0 0 0 52 6 2489 0.88348 1.0 1.0 0.0 0 0 0 0 0 GO:0007275 3 multicellular organism development 107 118 3 3 1 1 0 0 52 118 2377 0.082716 1.0 0.17282 0.0 0 0 0 0 0 GO:0007281 4 germ cell development 25 25 1 1 0 0 0 0 52 25 2470 0.59562 1.0 1.0 0.0 0 0 0 0 0 GO:0007286 5 spermatid development 12 12 1 1 0 0 0 0 52 12 2483 0.7803 1.0 1.0 0.0 0 0 0 0 0 GO:0007369 5 gastrulation 15 17 1 1 0 1 0 0 52 17 2478 0.70343 1.0 1.0 0.0 0 0 0 0 0 GO:0007389 3 pattern specification process 49 53 2 1 0 2 0 0 52 53 2442 0.33131 1.0 0.62624 0.0 0 0 0 0 0 GO:0007586 3 digestion 1 1 1 1 0 1 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:0007605 7 sensory perception of sound 26 26 1 1 0 0 0 0 52 26 2469 0.58334 1.0 1.0 0.0 0 0 0 0 0 GO:0007612 6 learning 40 43 1 1 0 1 0 0 52 43 2452 0.40883 1.0 1.0 0.0 0 0 0 0 0 GO:0007614 7 short-term memory 2 2 1 1 0 1 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:0008016 7 regulation of heart contraction 36 40 1 1 0 1 0 0 52 40 2455 0.43537 1.0 1.0 0.0 0 0 0 0 0 GO:0008064 7 regulation of actin polymerization or depolymerization 34 36 1 1 0 0 0 0 52 36 2459 0.47341 1.0 1.0 0.0 0 0 0 0 0 GO:0008088 7 axo-dendritic transport 12 15 1 1 0 1 0 0 52 15 2480 0.73325 1.0 1.0 0.0 0 0 0 0 0 GO:0008089 9 anterograde axonal transport 8 8 1 1 0 1 0 0 52 8 2487 0.84768 1.0 1.0 0.0 0 0 0 0 0 GO:0008104 4 protein localization 289 309 7 7 0 5 0 0 52 309 2186 0.0011157 1.0 0.001974 0.0 0 0 0 0 0 GO:0008203 6 cholesterol metabolic process 48 49 7 7 0 7 0 0 52 49 2446 0.36042 1.0 0.62471 0.0 0 0 0 0 0 GO:0008206 7 bile acid metabolic process 10 11 1 1 0 1 0 0 52 11 2484 0.79664 1.0 1.0 0.0 0 0 0 0 0 GO:0008207 6 C21-steroid hormone metabolic process 8 12 1 1 0 1 0 0 52 12 2483 0.7803 1.0 1.0 0.0 0 0 0 0 0 GO:0008209 6 androgen metabolic process 15 15 1 1 0 1 0 0 52 15 2480 0.73325 1.0 1.0 0.0 0 0 0 0 0 GO:0008213 7 protein alkylation 16 19 1 1 0 1 0 0 52 19 2476 0.67481 1.0 1.0 0.0 0 0 0 0 0 GO:0008277 6 regulation of G protein-coupled receptor signaling pathway 29 29 1 0 0 0 0 0 52 29 2466 0.54796 1.0 1.0 0.0 0 0 0 0 0 GO:0008286 8 insulin receptor signaling pathway 24 24 4 4 1 3 0 0 52 24 2471 0.60815 1.0 1.0 0.0 0 0 0 0 0 GO:0008360 5 regulation of cell shape 41 41 1 1 0 0 0 0 52 41 2454 0.42634 1.0 1.0 0.0 0 0 0 0 0 GO:0008543 8 fibroblast growth factor receptor signaling pathway 12 13 1 1 1 0 0 0 52 13 2482 0.7643 1.0 1.0 0.0 0 0 0 0 0 GO:0008589 6 regulation of smoothened signaling pathway 9 10 1 1 0 0 0 0 52 10 2485 0.81331 1.0 1.0 0.0 0 0 0 0 0 GO:0008608 4 attachment of spindle microtubules to kinetochore 5 7 1 1 0 0 0 0 52 7 2488 0.8654 1.0 1.0 0.0 0 0 0 0 0 GO:0008611 6 ether lipid biosynthetic process 1 1 1 0 0 0 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:0008630 7 intrinsic apoptotic signaling pathway in response to DNA damage 37 38 1 1 1 0 0 0 52 38 2457 0.454 1.0 1.0 0.0 0 0 0 0 0 GO:0008631 7 intrinsic apoptotic signaling pathway in response to oxidative stress 9 9 1 1 0 1 0 0 52 9 2486 0.83032 1.0 1.0 0.0 0 0 0 0 0 GO:0008643 6 carbohydrate transport 15 17 2 1 0 0 0 0 52 17 2478 0.70343 1.0 1.0 0.0 0 0 0 0 0 GO:0008645 7 hexose transmembrane transport 5 7 2 1 0 0 0 0 52 7 2488 0.8654 1.0 1.0 0.0 0 0 0 0 0 GO:0008654 5 phospholipid biosynthetic process 31 34 2 2 0 2 0 0 52 34 2461 0.49363 1.0 1.0 0.0 0 0 0 0 0 GO:0009051 5 pentose-phosphate shunt, oxidative branch 1 1 1 1 0 1 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:0009062 6 fatty acid catabolic process 37 42 3 3 0 1 0 0 52 42 2453 0.4175 1.0 1.0 0.0 0 0 0 0 0 GO:0009065 8 glutamine family amino acid catabolic process 8 9 1 1 0 1 0 0 52 9 2486 0.83032 1.0 1.0 0.0 0 0 0 0 0 GO:0009069 8 serine family amino acid metabolic process 11 13 2 2 1 1 0 0 52 13 2482 0.7643 1.0 1.0 0.0 0 0 0 0 0 GO:0009070 8 serine family amino acid biosynthetic process 3 4 1 1 1 0 0 0 52 4 2491 0.92076 1.0 1.0 0.0 0 0 0 0 0 GO:0009072 6 aromatic amino acid family metabolic process 16 17 1 1 1 0 0 0 52 17 2478 0.70343 1.0 1.0 0.0 0 0 0 0 0 GO:0009074 6 aromatic amino acid family catabolic process 13 13 1 1 1 0 0 0 52 13 2482 0.7643 1.0 1.0 0.0 0 0 0 0 0 GO:0009084 8 glutamine family amino acid biosynthetic process 4 4 1 1 1 0 0 0 52 4 2491 0.92076 1.0 1.0 0.0 0 0 0 0 0 GO:0009086 7 methionine biosynthetic process 4 4 1 1 0 1 0 0 52 4 2491 0.92076 1.0 1.0 0.0 0 0 0 0 0 GO:0009100 5 glycoprotein metabolic process 20 20 1 1 0 1 0 0 52 20 2475 0.66093 1.0 1.0 0.0 0 0 0 0 0 GO:0009101 6 glycoprotein biosynthetic process 12 12 1 1 0 1 0 0 52 12 2483 0.7803 1.0 1.0 0.0 0 0 0 0 0 GO:0009116 6 nucleoside metabolic process 13 17 1 1 0 1 0 0 52 17 2478 0.70343 1.0 1.0 0.0 0 0 0 0 0 GO:0009119 7 ribonucleoside metabolic process 9 12 1 1 0 1 0 0 52 12 2483 0.7803 1.0 1.0 0.0 0 0 0 0 0 GO:0009132 6 nucleoside diphosphate metabolic process 16 21 2 1 0 1 0 0 52 21 2474 0.64733 1.0 1.0 0.0 0 0 0 0 0 GO:0009135 7 purine nucleoside diphosphate metabolic process 14 19 1 0 0 0 0 0 52 19 2476 0.67481 1.0 1.0 0.0 0 0 0 0 0 GO:0009141 6 nucleoside triphosphate metabolic process 19 19 1 0 0 0 0 0 52 19 2476 0.67481 1.0 1.0 0.0 0 0 0 0 0 GO:0009142 7 nucleoside triphosphate biosynthetic process 14 14 1 0 0 0 0 0 52 14 2481 0.74861 1.0 1.0 0.0 0 0 0 0 0 GO:0009144 7 purine nucleoside triphosphate metabolic process 13 13 1 0 0 0 0 0 52 13 2482 0.7643 1.0 1.0 0.0 0 0 0 0 0 GO:0009145 8 purine nucleoside triphosphate biosynthetic process 10 10 1 0 0 0 0 0 52 10 2485 0.81331 1.0 1.0 0.0 0 0 0 0 0 GO:0009152 8 purine ribonucleotide biosynthetic process 31 36 2 0 0 0 0 0 52 36 2459 0.47341 1.0 1.0 0.0 0 0 0 0 0 GO:0009165 7 nucleotide biosynthetic process 50 55 3 1 0 1 0 0 52 55 2440 0.31764 1.0 0.62784 0.0 0 0 0 0 0 GO:0009179 8 purine ribonucleoside diphosphate metabolic process 14 19 1 0 0 0 0 0 52 19 2476 0.67481 1.0 1.0 0.0 0 0 0 0 0 GO:0009185 7 ribonucleoside diphosphate metabolic process 14 19 1 0 0 0 0 0 52 19 2476 0.67481 1.0 1.0 0.0 0 0 0 0 0 GO:0009199 7 ribonucleoside triphosphate metabolic process 12 12 1 0 0 0 0 0 52 12 2483 0.7803 1.0 1.0 0.0 0 0 0 0 0 GO:0009201 8 ribonucleoside triphosphate biosynthetic process 10 10 1 0 0 0 0 0 52 10 2485 0.81331 1.0 1.0 0.0 0 0 0 0 0 GO:0009205 8 purine ribonucleoside triphosphate metabolic process 11 11 1 0 0 0 0 0 52 11 2484 0.79664 1.0 1.0 0.0 0 0 0 0 0 GO:0009206 9 purine ribonucleoside triphosphate biosynthetic process 9 9 1 0 0 0 0 0 52 9 2486 0.83032 1.0 1.0 0.0 0 0 0 0 0 GO:0009251 7 glucan catabolic process 4 4 1 1 0 1 0 0 52 4 2491 0.92076 1.0 1.0 0.0 0 0 0 0 0 GO:0009260 7 ribonucleotide biosynthetic process 32 37 2 0 0 0 0 0 52 37 2458 0.46361 1.0 1.0 0.0 0 0 0 0 0 GO:0009268 4 response to pH 14 16 2 2 0 2 0 0 52 16 2479 0.71819 1.0 1.0 0.0 0 0 0 0 0 GO:0009299 7 mRNA transcription 8 8 1 1 0 1 0 0 52 8 2487 0.84768 1.0 1.0 0.0 0 0 0 0 0 GO:0009306 5 protein secretion 26 28 1 1 0 0 0 0 52 28 2467 0.55952 1.0 1.0 0.0 0 0 0 0 0 GO:0009309 6 amine biosynthetic process 2 3 1 1 1 0 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:0009403 5 toxin biosynthetic process 1 2 1 1 0 1 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:0009405 3 pathogenesis 1 1 1 1 1 0 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:0009408 4 response to heat 54 59 1 0 0 0 0 0 52 59 2436 0.29193 1.0 0.63248 0.0 0 0 0 0 0 GO:0009415 4 response to water 12 12 1 1 1 0 0 0 52 12 2483 0.7803 1.0 1.0 0.0 0 0 0 0 0 GO:0009581 4 detection of external stimulus 25 26 1 1 1 0 0 0 52 26 2469 0.58334 1.0 1.0 0.0 0 0 0 0 0 GO:0009582 4 detection of abiotic stimulus 25 26 1 1 1 0 0 0 52 26 2469 0.58334 1.0 1.0 0.0 0 0 0 0 0 GO:0009712 6 catechol-containing compound metabolic process 12 14 2 2 1 1 0 0 52 14 2481 0.74861 1.0 1.0 0.0 0 0 0 0 0 GO:0009713 7 catechol-containing compound biosynthetic process 8 8 1 1 1 0 0 0 52 8 2487 0.84768 1.0 1.0 0.0 0 0 0 0 0 GO:0009750 8 response to fructose 10 10 2 1 0 1 0 0 52 10 2485 0.81331 1.0 1.0 0.0 0 0 0 0 0 GO:0009755 5 hormone-mediated signaling pathway 41 44 1 1 0 1 0 0 52 44 2451 0.40034 1.0 1.0 0.0 0 0 0 0 0 GO:0009790 4 embryo development 68 71 2 2 1 1 0 0 52 71 2424 0.22644 1.0 0.40159 0.0 0 0 0 0 0 GO:0009791 3 post-embryonic development 25 26 2 2 0 2 0 0 52 26 2469 0.58334 1.0 1.0 0.0 0 0 0 0 0 GO:0009792 5 embryo development ending in birth or egg hatching 67 70 2 2 1 1 0 0 52 70 2425 0.2313 1.0 0.40137 0.0 0 0 0 0 0 GO:0009798 4 axis specification 10 10 1 1 0 1 0 0 52 10 2485 0.81331 1.0 1.0 0.0 0 0 0 0 0 GO:0009820 5 alkaloid metabolic process 3 3 1 1 0 1 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:0009895 6 negative regulation of catabolic process 80 83 4 4 1 1 0 0 52 83 2412 0.17542 1.0 0.41444 0.0 0 0 0 0 0 GO:0009948 5 anterior/posterior axis specification 6 6 1 1 0 1 0 0 52 6 2489 0.88348 1.0 1.0 0.0 0 0 0 0 0 GO:0009952 5 anterior/posterior pattern specification 22 26 1 0 0 1 0 0 52 26 2469 0.58334 1.0 1.0 0.0 0 0 0 0 0 GO:0010040 7 response to iron(II) ion 7 7 1 1 0 1 0 0 52 7 2488 0.8654 1.0 1.0 0.0 0 0 0 0 0 GO:0010045 6 response to nickel cation 1 2 1 1 1 0 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:0010133 8 proline catabolic process to glutamate 1 1 1 1 0 1 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:0010273 4 detoxification of copper ion 1 3 1 1 0 1 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:0010383 6 cell wall polysaccharide metabolic process 1 1 1 1 1 0 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:0010447 5 response to acidic pH 8 9 1 1 0 1 0 0 52 9 2486 0.83032 1.0 1.0 0.0 0 0 0 0 0 GO:0010464 6 regulation of mesenchymal cell proliferation 11 11 1 1 1 0 0 0 52 11 2484 0.79664 1.0 1.0 0.0 0 0 0 0 0 GO:0010467 5 gene expression 44 44 1 1 0 1 0 0 52 44 2451 0.40034 1.0 1.0 0.0 0 0 0 0 0 GO:0010470 6 regulation of gastrulation 12 12 1 1 0 1 0 0 52 12 2483 0.7803 1.0 1.0 0.0 0 0 0 0 0 GO:0010477 5 response to sulfur dioxide 1 2 1 1 0 0 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:0010508 8 positive regulation of autophagy 35 37 3 2 0 1 0 0 52 37 2458 0.46361 1.0 1.0 0.0 0 0 0 0 0 GO:0010510 8 regulation of acetyl-CoA biosynthetic process from pyruvate 2 2 1 1 0 1 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:0010608 7 posttranscriptional regulation of gene expression 70 78 5 5 1 2 0 0 52 78 2417 0.19514 1.0 0.40697 0.0 0 0 0 0 0 GO:0010611 6 regulation of cardiac muscle hypertrophy 26 26 2 2 0 2 0 0 52 26 2469 0.58334 1.0 1.0 0.0 0 0 0 0 0 GO:0010613 7 positive regulation of cardiac muscle hypertrophy 15 15 1 1 0 1 0 0 52 15 2480 0.73325 1.0 1.0 0.0 0 0 0 0 0 GO:0010614 7 negative regulation of cardiac muscle hypertrophy 10 10 1 1 0 1 0 0 52 10 2485 0.81331 1.0 1.0 0.0 0 0 0 0 0 GO:0010631 6 epithelial cell migration 28 30 2 2 0 2 0 0 52 30 2465 0.53665 1.0 1.0 0.0 0 0 0 0 0 GO:0010638 7 positive regulation of organelle organization 145 155 6 5 0 2 0 0 52 155 2340 0.036916 1.0 0.072629 0.0 0 0 0 0 0 GO:0010676 7 positive regulation of cellular carbohydrate metabolic process 20 20 1 1 0 1 0 0 52 20 2475 0.66093 1.0 1.0 0.0 0 0 0 0 0 GO:0010692 8 regulation of alkaline phosphatase activity 5 6 1 1 0 1 0 0 52 6 2489 0.88348 1.0 1.0 0.0 0 0 0 0 0 GO:0010694 9 positive regulation of alkaline phosphatase activity 3 3 1 1 0 1 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:0010732 8 regulation of protein glutathionylation 2 2 1 1 0 1 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:0010734 9 negative regulation of protein glutathionylation 2 2 1 1 0 1 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:0010749 7 regulation of nitric oxide mediated signal transduction 4 4 1 1 1 0 0 0 52 4 2491 0.92076 1.0 1.0 0.0 0 0 0 0 0 GO:0010751 8 negative regulation of nitric oxide mediated signal transduction 1 1 1 1 1 0 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:0010769 7 regulation of cell morphogenesis involved in differentiation 72 76 1 1 0 1 0 0 52 76 2419 0.20362 1.0 0.40479 0.0 0 0 0 0 0 GO:0010770 8 positive regulation of cell morphogenesis involved in differentiation 40 44 1 1 0 1 0 0 52 44 2451 0.40034 1.0 1.0 0.0 0 0 0 0 0 GO:0010803 7 regulation of tumor necrosis factor-mediated signaling pathway 11 11 1 1 0 1 0 0 52 11 2484 0.79664 1.0 1.0 0.0 0 0 0 0 0 GO:0010804 8 negative regulation of tumor necrosis factor-mediated signaling pathway 4 4 1 1 0 1 0 0 52 4 2491 0.92076 1.0 1.0 0.0 0 0 0 0 0 GO:0010810 6 regulation of cell-substrate adhesion 67 71 1 1 0 1 0 0 52 71 2424 0.22644 1.0 0.40159 0.0 0 0 0 0 0 GO:0010811 7 positive regulation of cell-substrate adhesion 40 43 1 1 0 1 0 0 52 43 2452 0.40883 1.0 1.0 0.0 0 0 0 0 0 GO:0010821 7 regulation of mitochondrion organization 47 48 1 1 0 1 0 0 52 48 2447 0.36808 1.0 0.62471 0.0 0 0 0 0 0 GO:0010829 7 negative regulation of glucose transmembrane transport 5 7 1 1 1 0 0 0 52 7 2488 0.8654 1.0 1.0 0.0 0 0 0 0 0 GO:0010833 7 telomere maintenance via telomere lengthening 5 7 1 1 0 1 0 0 52 7 2488 0.8654 1.0 1.0 0.0 0 0 0 0 0 GO:0010837 7 regulation of keratinocyte proliferation 7 8 1 1 0 0 0 0 52 8 2487 0.84768 1.0 1.0 0.0 0 0 0 0 0 GO:0010866 7 regulation of triglyceride biosynthetic process 13 13 2 2 0 2 0 0 52 13 2482 0.7643 1.0 1.0 0.0 0 0 0 0 0 GO:0010867 8 positive regulation of triglyceride biosynthetic process 10 10 2 2 0 2 0 0 52 10 2485 0.81331 1.0 1.0 0.0 0 0 0 0 0 GO:0010872 6 regulation of cholesterol esterification 4 4 1 1 0 1 0 0 52 4 2491 0.92076 1.0 1.0 0.0 0 0 0 0 0 GO:0010873 7 positive regulation of cholesterol esterification 4 4 1 1 0 1 0 0 52 4 2491 0.92076 1.0 1.0 0.0 0 0 0 0 0 GO:0010874 9 regulation of cholesterol efflux 9 10 1 1 0 1 0 0 52 10 2485 0.81331 1.0 1.0 0.0 0 0 0 0 0 GO:0010875 9 positive regulation of cholesterol efflux 9 9 1 1 0 1 0 0 52 9 2486 0.83032 1.0 1.0 0.0 0 0 0 0 0 GO:0010876 4 lipid localization 4 4 1 1 0 1 0 0 52 4 2491 0.92076 1.0 1.0 0.0 0 0 0 0 0 GO:0010893 8 positive regulation of steroid biosynthetic process 18 20 2 2 0 2 0 0 52 20 2475 0.66093 1.0 1.0 0.0 0 0 0 0 0 GO:0010896 7 regulation of triglyceride catabolic process 9 11 3 3 1 2 0 0 52 11 2484 0.79664 1.0 1.0 0.0 0 0 0 0 0 GO:0010897 8 negative regulation of triglyceride catabolic process 4 4 1 1 0 1 0 0 52 4 2491 0.92076 1.0 1.0 0.0 0 0 0 0 0 GO:0010898 8 positive regulation of triglyceride catabolic process 5 7 2 2 1 1 0 0 52 7 2488 0.8654 1.0 1.0 0.0 0 0 0 0 0 GO:0010901 5 regulation of very-low-density lipoprotein particle remodeling 3 3 1 1 0 1 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:0010903 6 negative regulation of very-low-density lipoprotein particle remodeling 3 3 1 1 0 1 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:0010907 7 positive regulation of glucose metabolic process 14 14 1 1 0 1 0 0 52 14 2481 0.74861 1.0 1.0 0.0 0 0 0 0 0 GO:0010918 6 positive regulation of mitochondrial membrane potential 7 7 1 1 1 0 0 0 52 7 2488 0.8654 1.0 1.0 0.0 0 0 0 0 0 GO:0010922 8 positive regulation of phosphatase activity 12 14 1 1 0 1 0 0 52 14 2481 0.74861 1.0 1.0 0.0 0 0 0 0 0 GO:0010950 8 positive regulation of endopeptidase activity 54 58 1 1 1 0 0 0 52 58 2437 0.29816 1.0 0.63115 0.0 0 0 0 0 0 GO:0010952 7 positive regulation of peptidase activity 63 67 1 1 1 0 0 0 52 67 2428 0.24648 1.0 0.64646 0.0 0 0 0 0 0 GO:0010965 7 regulation of mitotic sister chromatid separation 16 16 1 1 0 0 0 0 52 16 2479 0.71819 1.0 1.0 0.0 0 0 0 0 0 GO:0010970 6 transport along microtubule 17 20 1 1 0 1 0 0 52 20 2475 0.66093 1.0 1.0 0.0 0 0 0 0 0 GO:0010977 8 negative regulation of neuron projection development 36 38 1 1 0 1 0 0 52 38 2457 0.454 1.0 1.0 0.0 0 0 0 0 0 GO:0010982 6 regulation of high-density lipoprotein particle clearance 2 2 1 1 0 1 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:0010983 7 positive regulation of high-density lipoprotein particle clearance 1 1 1 1 0 1 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:0010984 5 regulation of lipoprotein particle clearance 8 8 1 1 0 1 0 0 52 8 2487 0.84768 1.0 1.0 0.0 0 0 0 0 0 GO:0010986 6 positive regulation of lipoprotein particle clearance 2 2 1 1 0 1 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:0014012 8 peripheral nervous system axon regeneration 7 7 1 1 0 1 0 0 52 7 2488 0.8654 1.0 1.0 0.0 0 0 0 0 0 GO:0014735 6 regulation of muscle atrophy 3 3 1 1 0 1 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:0014737 7 positive regulation of muscle atrophy 2 2 1 1 0 1 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:0014741 6 negative regulation of muscle hypertrophy 10 10 1 1 0 1 0 0 52 10 2485 0.81331 1.0 1.0 0.0 0 0 0 0 0 GO:0014742 6 positive regulation of muscle hypertrophy 15 15 1 1 0 1 0 0 52 15 2480 0.73325 1.0 1.0 0.0 0 0 0 0 0 GO:0014743 7 regulation of muscle hypertrophy 26 26 2 2 0 2 0 0 52 26 2469 0.58334 1.0 1.0 0.0 0 0 0 0 0 GO:0014744 6 positive regulation of muscle adaptation 4 4 1 1 0 1 0 0 52 4 2491 0.92076 1.0 1.0 0.0 0 0 0 0 0 GO:0014904 7 myotube cell development 8 8 1 1 1 0 0 0 52 8 2487 0.84768 1.0 1.0 0.0 0 0 0 0 0 GO:0015012 8 heparan sulfate proteoglycan biosynthetic process 3 3 1 1 0 1 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:0015031 5 protein transport 172 184 2 2 0 1 0 0 52 184 2311 0.019443 1.0 0.030144 0.0 0 0 0 0 0 GO:0015727 7 lactate transport 2 2 1 1 1 0 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:0015748 6 organophosphate ester transport 28 28 1 1 0 1 0 0 52 28 2467 0.55952 1.0 1.0 0.0 0 0 0 0 0 GO:0015749 6 monosaccharide transmembrane transport 5 7 2 1 0 0 0 0 52 7 2488 0.8654 1.0 1.0 0.0 0 0 0 0 0 GO:0015755 8 fructose transmembrane transport 2 2 1 0 0 0 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:0015833 6 peptide transport 179 191 2 2 0 1 0 0 52 191 2304 0.016635 1.0 0.030145 0.0 0 0 0 0 0 GO:0015914 7 phospholipid transport 20 20 1 1 0 1 0 0 52 20 2475 0.66093 1.0 1.0 0.0 0 0 0 0 0 GO:0015931 6 nucleobase-containing compound transport 29 31 1 1 0 0 0 0 52 31 2464 0.52556 1.0 1.0 0.0 0 0 0 0 0 GO:0015980 4 energy derivation by oxidation of organic compounds 29 31 2 2 0 2 0 0 52 31 2464 0.52556 1.0 1.0 0.0 0 0 0 0 0 GO:0016032 4 viral process 22 23 1 1 1 0 0 0 52 23 2472 0.62094 1.0 1.0 0.0 0 0 0 0 0 GO:0016036 6 cellular response to phosphate starvation 1 1 1 1 0 1 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:0016049 3 cell growth 20 23 1 1 0 1 0 0 52 23 2472 0.62094 1.0 1.0 0.0 0 0 0 0 0 GO:0016050 6 vesicle organization 36 39 1 1 0 1 0 0 52 39 2456 0.44459 1.0 1.0 0.0 0 0 0 0 0 GO:0016051 5 carbohydrate biosynthetic process 27 32 4 3 0 3 0 0 52 32 2463 0.5147 1.0 1.0 0.0 0 0 0 0 0 GO:0016052 5 carbohydrate catabolic process 24 30 3 2 0 2 0 0 52 30 2465 0.53665 1.0 1.0 0.0 0 0 0 0 0 GO:0016071 7 mRNA metabolic process 53 60 3 3 1 1 0 0 52 60 2435 0.28583 1.0 0.63391 0.0 0 0 0 0 0 GO:0016098 7 monoterpenoid metabolic process 2 3 1 1 0 1 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:0016125 5 sterol metabolic process 51 52 7 7 0 7 0 0 52 52 2443 0.33837 1.0 0.62564 0.0 0 0 0 0 0 GO:0016126 6 sterol biosynthetic process 25 25 4 4 0 4 0 0 52 25 2470 0.59562 1.0 1.0 0.0 0 0 0 0 0 GO:0016127 6 sterol catabolic process 4 4 1 1 0 1 0 0 52 4 2491 0.92076 1.0 1.0 0.0 0 0 0 0 0 GO:0016128 5 phytosteroid metabolic process 2 2 1 1 0 1 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:0016129 6 phytosteroid biosynthetic process 2 2 1 1 0 1 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:0016131 5 brassinosteroid metabolic process 1 1 1 1 0 1 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:0016132 6 brassinosteroid biosynthetic process 1 1 1 1 0 1 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:0016137 6 glycoside metabolic process 4 5 1 1 0 1 0 0 52 5 2490 0.90193 1.0 1.0 0.0 0 0 0 0 0 GO:0016192 4 vesicle-mediated transport 163 173 1 1 0 1 0 0 52 173 2322 0.024819 1.0 0.04685 0.0 0 0 0 0 0 GO:0016202 6 regulation of striated muscle tissue development 55 57 3 3 0 3 0 0 52 57 2438 0.30452 1.0 0.62993 0.0 0 0 0 0 0 GO:0016236 5 macroautophagy 11 11 1 1 0 1 0 0 52 11 2484 0.79664 1.0 1.0 0.0 0 0 0 0 0 GO:0016239 9 positive regulation of macroautophagy 19 21 1 1 0 0 0 0 52 21 2474 0.64733 1.0 1.0 0.0 0 0 0 0 0 GO:0016241 8 regulation of macroautophagy 26 28 1 1 0 0 0 0 52 28 2467 0.55952 1.0 1.0 0.0 0 0 0 0 0 GO:0016485 6 protein processing 34 36 1 1 1 0 0 0 52 36 2459 0.47341 1.0 1.0 0.0 0 0 0 0 0 GO:0016569 6 covalent chromatin modification 49 53 1 1 0 1 0 0 52 53 2442 0.33131 1.0 0.62624 0.0 0 0 0 0 0 GO:0016570 7 histone modification 48 51 1 1 0 1 0 0 52 51 2444 0.34556 1.0 0.62518 0.0 0 0 0 0 0 GO:0016572 8 histone phosphorylation 12 12 1 1 0 1 0 0 52 12 2483 0.7803 1.0 1.0 0.0 0 0 0 0 0 GO:0017145 4 stem cell division 11 11 1 0 0 0 0 0 52 11 2484 0.79664 1.0 1.0 0.0 0 0 0 0 0 GO:0017148 8 negative regulation of translation 21 22 2 2 0 0 0 0 52 22 2473 0.634 1.0 1.0 0.0 0 0 0 0 0 GO:0018057 7 peptidyl-lysine oxidation 2 2 1 1 0 1 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:0018105 8 peptidyl-serine phosphorylation 56 56 3 3 0 2 0 0 52 56 2439 0.31101 1.0 0.62883 0.0 0 0 0 0 0 GO:0018158 6 protein oxidation 8 8 2 2 0 2 0 0 52 8 2487 0.84768 1.0 1.0 0.0 0 0 0 0 0 GO:0018193 7 peptidyl-amino acid modification 169 184 6 6 0 4 0 0 52 184 2311 0.019443 1.0 0.030144 0.0 0 0 0 0 0 GO:0018196 8 peptidyl-asparagine modification 4 4 1 1 0 0 0 0 52 4 2491 0.92076 1.0 1.0 0.0 0 0 0 0 0 GO:0018205 8 peptidyl-lysine modification 36 39 1 1 0 1 0 0 52 39 2456 0.44459 1.0 1.0 0.0 0 0 0 0 0 GO:0018206 8 peptidyl-methionine modification 2 2 1 1 0 1 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:0018209 8 peptidyl-serine modification 61 61 3 3 0 2 0 0 52 61 2434 0.27985 1.0 0.63545 0.0 0 0 0 0 0 GO:0018279 8 protein N-linked glycosylation via asparagine 4 4 1 1 0 0 0 0 52 4 2491 0.92076 1.0 1.0 0.0 0 0 0 0 0 GO:0018298 7 protein-chromophore linkage 4 4 1 0 0 0 0 0 52 4 2491 0.92076 1.0 1.0 0.0 0 0 0 0 0 GO:0018958 5 phenol-containing compound metabolic process 27 31 2 2 1 1 0 0 52 31 2464 0.52556 1.0 1.0 0.0 0 0 0 0 0 GO:0019048 5 modulation by virus of host process 11 11 1 1 1 0 0 0 52 11 2484 0.79664 1.0 1.0 0.0 0 0 0 0 0 GO:0019062 5 virion attachment to host cell 2 2 1 1 0 0 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:0019087 6 transformation of host cell by virus 2 2 1 1 1 0 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:0019229 7 regulation of vasoconstriction 30 31 1 1 0 0 0 0 52 31 2464 0.52556 1.0 1.0 0.0 0 0 0 0 0 GO:0019285 6 glycine betaine biosynthetic process from choline 2 2 1 1 0 1 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:0019318 5 hexose metabolic process 48 54 8 7 2 5 0 0 52 54 2441 0.32441 1.0 0.62697 0.0 0 0 0 0 0 GO:0019319 6 hexose biosynthetic process 10 13 3 2 0 2 0 0 52 13 2482 0.7643 1.0 1.0 0.0 0 0 0 0 0 GO:0019320 6 hexose catabolic process 6 8 1 1 0 1 0 0 52 8 2487 0.84768 1.0 1.0 0.0 0 0 0 0 0 GO:0019321 5 pentose metabolic process 4 4 1 1 0 1 0 0 52 4 2491 0.92076 1.0 1.0 0.0 0 0 0 0 0 GO:0019322 6 pentose biosynthetic process 1 1 1 1 0 1 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:0019336 6 phenol-containing compound catabolic process 4 4 1 1 0 1 0 0 52 4 2491 0.92076 1.0 1.0 0.0 0 0 0 0 0 GO:0019359 8 nicotinamide nucleotide biosynthetic process 7 7 1 1 0 1 0 0 52 7 2488 0.8654 1.0 1.0 0.0 0 0 0 0 0 GO:0019362 6 pyridine nucleotide metabolic process 7 7 1 1 0 1 0 0 52 7 2488 0.8654 1.0 1.0 0.0 0 0 0 0 0 GO:0019363 7 pyridine nucleotide biosynthetic process 7 7 1 1 0 1 0 0 52 7 2488 0.8654 1.0 1.0 0.0 0 0 0 0 0 GO:0019388 7 galactose catabolic process 3 3 1 1 0 1 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:0019395 7 fatty acid oxidation 39 43 1 1 0 0 0 0 52 43 2452 0.40883 1.0 1.0 0.0 0 0 0 0 0 GO:0019400 5 alditol metabolic process 6 6 1 1 0 1 0 0 52 6 2489 0.88348 1.0 1.0 0.0 0 0 0 0 0 GO:0019401 6 alditol biosynthetic process 3 3 1 1 0 1 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:0019541 8 propionate metabolic process 4 4 1 1 0 1 0 0 52 4 2491 0.92076 1.0 1.0 0.0 0 0 0 0 0 GO:0019543 8 propionate catabolic process 2 2 1 1 0 1 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:0019614 7 catechol-containing compound catabolic process 3 3 1 1 0 1 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:0019626 7 short-chain fatty acid catabolic process 3 3 1 1 0 1 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:0019674 3 NAD metabolic process 7 9 1 1 0 1 0 0 52 9 2486 0.83032 1.0 1.0 0.0 0 0 0 0 0 GO:0019695 5 choline metabolic process 3 3 1 1 0 1 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:0019827 3 stem cell population maintenance 26 27 2 1 0 1 0 0 52 27 2468 0.5713 1.0 1.0 0.0 0 0 0 0 0 GO:0019882 3 antigen processing and presentation 24 35 1 1 0 0 0 0 52 35 2460 0.48342 1.0 1.0 0.0 0 0 0 0 0 GO:0019915 4 lipid storage 15 17 3 2 0 2 0 0 52 17 2478 0.70343 1.0 1.0 0.0 0 0 0 0 0 GO:0021680 4 cerebellar Purkinje cell layer development 4 4 1 1 0 1 0 0 52 4 2491 0.92076 1.0 1.0 0.0 0 0 0 0 0 GO:0021854 4 hypothalamus development 7 7 1 1 1 0 0 0 52 7 2488 0.8654 1.0 1.0 0.0 0 0 0 0 0 GO:0022406 3 membrane docking 13 14 1 1 0 0 0 0 52 14 2481 0.74861 1.0 1.0 0.0 0 0 0 0 0 GO:0022407 6 regulation of cell-cell adhesion 137 143 2 2 0 1 0 0 52 143 2352 0.048023 1.0 0.11627 0.0 0 0 0 0 0 GO:0022408 7 negative regulation of cell-cell adhesion 60 62 1 1 0 1 0 0 52 62 2433 0.274 1.0 0.63707 0.0 0 0 0 0 0 GO:0022409 7 positive regulation of cell-cell adhesion 88 92 1 1 0 0 0 0 52 92 2403 0.14474 1.0 0.2608 0.0 0 0 0 0 0 GO:0022411 5 cellular component disassembly 46 49 2 2 1 1 0 0 52 49 2446 0.36042 1.0 0.62471 0.0 0 0 0 0 0 GO:0022604 6 regulation of cell morphogenesis 114 118 2 2 0 1 0 0 52 118 2377 0.082716 1.0 0.17282 0.0 0 0 0 0 0 GO:0022610 2 biological adhesion 150 155 2 2 1 0 0 0 52 155 2340 0.036916 1.0 0.072629 0.0 0 0 0 0 0 GO:0022614 4 membrane to membrane docking 3 3 1 1 0 0 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:0023014 7 signal transduction by protein phosphorylation 49 51 3 3 1 1 0 0 52 51 2444 0.34556 1.0 0.62518 0.0 0 0 0 0 0 GO:0023052 2 signaling 77 79 1 1 1 0 0 0 52 79 2416 0.19103 1.0 0.40824 0.0 0 0 0 0 0 GO:0030071 8 regulation of mitotic metaphase/anaphase transition 15 15 1 1 0 0 0 0 52 15 2480 0.73325 1.0 1.0 0.0 0 0 0 0 0 GO:0030097 6 hemopoiesis 28 29 1 1 0 1 0 0 52 29 2466 0.54796 1.0 1.0 0.0 0 0 0 0 0 GO:0030104 6 water homeostasis 14 14 1 1 0 1 0 0 52 14 2481 0.74861 1.0 1.0 0.0 0 0 0 0 0 GO:0030155 5 regulation of cell adhesion 210 219 2 2 0 1 0 0 52 219 2276 0.0088723 1.0 0.020201 0.0 0 0 0 0 0 GO:0030166 7 proteoglycan biosynthetic process 8 8 1 1 0 1 0 0 52 8 2487 0.84768 1.0 1.0 0.0 0 0 0 0 0 GO:0030201 7 heparan sulfate proteoglycan metabolic process 5 5 1 1 0 1 0 0 52 5 2490 0.90193 1.0 1.0 0.0 0 0 0 0 0 GO:0030203 6 glycosaminoglycan metabolic process 21 21 1 1 0 1 0 0 52 21 2474 0.64733 1.0 1.0 0.0 0 0 0 0 0 GO:0030204 6 chondroitin sulfate metabolic process 4 4 1 1 0 1 0 0 52 4 2491 0.92076 1.0 1.0 0.0 0 0 0 0 0 GO:0030206 6 chondroitin sulfate biosynthetic process 2 2 1 1 0 1 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:0030223 8 neutrophil differentiation 3 3 1 0 0 0 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:0030224 7 monocyte differentiation 8 8 2 1 0 1 0 0 52 8 2487 0.84768 1.0 1.0 0.0 0 0 0 0 0 GO:0030307 6 positive regulation of cell growth 47 49 2 2 1 1 0 0 52 49 2446 0.36042 1.0 0.62471 0.0 0 0 0 0 0 GO:0030325 6 adrenal gland development 11 14 1 1 0 1 0 0 52 14 2481 0.74861 1.0 1.0 0.0 0 0 0 0 0 GO:0030330 7 DNA damage response, signal transduction by p53 class mediator 13 14 2 2 0 1 0 0 52 14 2481 0.74861 1.0 1.0 0.0 0 0 0 0 0 GO:0030433 8 ubiquitin-dependent ERAD pathway 11 11 1 1 0 0 0 0 52 11 2484 0.79664 1.0 1.0 0.0 0 0 0 0 0 GO:0030501 7 positive regulation of bone mineralization 11 12 1 1 0 0 0 0 52 12 2483 0.7803 1.0 1.0 0.0 0 0 0 0 0 GO:0030522 5 intracellular receptor signaling pathway 38 42 2 2 0 2 0 0 52 42 2453 0.4175 1.0 1.0 0.0 0 0 0 0 0 GO:0030573 7 bile acid catabolic process 1 1 1 1 0 1 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:0030638 4 polyketide metabolic process 1 1 1 1 0 1 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:0030647 6 aminoglycoside antibiotic metabolic process 1 1 1 1 0 1 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:0030705 5 cytoskeleton-dependent intracellular transport 21 24 1 1 0 1 0 0 52 24 2471 0.60815 1.0 1.0 0.0 0 0 0 0 0 GO:0030728 4 ovulation 14 18 2 2 1 1 0 0 52 18 2477 0.68897 1.0 1.0 0.0 0 0 0 0 0 GO:0030808 7 regulation of nucleotide biosynthetic process 11 12 2 2 1 1 0 0 52 12 2483 0.7803 1.0 1.0 0.0 0 0 0 0 0 GO:0030810 8 positive regulation of nucleotide biosynthetic process 7 8 1 1 1 0 0 0 52 8 2487 0.84768 1.0 1.0 0.0 0 0 0 0 0 GO:0030832 6 regulation of actin filament length 34 36 1 1 0 0 0 0 52 36 2459 0.47341 1.0 1.0 0.0 0 0 0 0 0 GO:0030833 8 regulation of actin filament polymerization 32 34 1 1 0 0 0 0 52 34 2461 0.49363 1.0 1.0 0.0 0 0 0 0 0 GO:0030838 8 positive regulation of actin filament polymerization 19 21 1 1 0 0 0 0 52 21 2474 0.64733 1.0 1.0 0.0 0 0 0 0 0 GO:0030851 7 granulocyte differentiation 5 6 1 0 0 0 0 0 52 6 2489 0.88348 1.0 1.0 0.0 0 0 0 0 0 GO:0030879 6 mammary gland development 15 16 1 0 0 0 0 0 52 16 2479 0.71819 1.0 1.0 0.0 0 0 0 0 0 GO:0030888 8 regulation of B cell proliferation 26 28 1 0 0 0 0 0 52 28 2467 0.55952 1.0 1.0 0.0 0 0 0 0 0 GO:0030890 9 positive regulation of B cell proliferation 17 19 1 0 0 0 0 0 52 19 2476 0.67481 1.0 1.0 0.0 0 0 0 0 0 GO:0031023 4 microtubule organizing center organization 13 14 1 1 0 1 0 0 52 14 2481 0.74861 1.0 1.0 0.0 0 0 0 0 0 GO:0031056 8 regulation of histone modification 33 33 2 2 0 1 0 0 52 33 2462 0.50406 1.0 1.0 0.0 0 0 0 0 0 GO:0031058 9 positive regulation of histone modification 24 24 2 2 0 1 0 0 52 24 2471 0.60815 1.0 1.0 0.0 0 0 0 0 0 GO:0031063 9 regulation of histone deacetylation 9 9 2 2 0 1 0 0 52 9 2486 0.83032 1.0 1.0 0.0 0 0 0 0 0 GO:0031065 10 positive regulation of histone deacetylation 8 8 2 2 0 1 0 0 52 8 2487 0.84768 1.0 1.0 0.0 0 0 0 0 0 GO:0031086 9 nuclear-transcribed mRNA catabolic process, deadenylation-independent decay 1 1 1 1 0 0 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:0031098 6 stress-activated protein kinase signaling cascade 26 27 1 1 0 0 0 0 52 27 2468 0.5713 1.0 1.0 0.0 0 0 0 0 0 GO:0031134 5 sister chromatid biorientation 1 1 1 1 0 0 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:0031330 7 negative regulation of cellular catabolic process 57 58 4 4 1 1 0 0 52 58 2437 0.29816 1.0 0.63115 0.0 0 0 0 0 0 GO:0031334 7 positive regulation of protein-containing complex assembly 61 68 1 1 0 0 0 0 52 68 2427 0.24132 1.0 0.40137 0.0 0 0 0 0 0 GO:0031335 7 regulation of sulfur amino acid metabolic process 2 2 1 1 0 1 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:0031337 8 positive regulation of sulfur amino acid metabolic process 1 1 1 1 0 1 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:0031345 7 negative regulation of cell projection organization 43 47 1 1 0 1 0 0 52 47 2448 0.37589 1.0 1.0 0.0 0 0 0 0 0 GO:0031348 6 negative regulation of defense response 64 68 4 4 0 2 0 0 52 68 2427 0.24132 1.0 0.40137 0.0 0 0 0 0 0 GO:0031397 10 negative regulation of protein ubiquitination 18 20 3 2 0 1 0 0 52 20 2475 0.66093 1.0 1.0 0.0 0 0 0 0 0 GO:0031455 6 glycine betaine metabolic process 2 2 1 1 0 1 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:0031456 7 glycine betaine biosynthetic process 2 2 1 1 0 1 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:0031529 7 ruffle organization 7 7 1 1 0 0 0 0 52 7 2488 0.8654 1.0 1.0 0.0 0 0 0 0 0 GO:0031532 6 actin cytoskeleton reorganization 15 15 1 1 0 0 0 0 52 15 2480 0.73325 1.0 1.0 0.0 0 0 0 0 0 GO:0031644 6 regulation of nervous system process 40 41 1 1 0 1 0 0 52 41 2454 0.42634 1.0 1.0 0.0 0 0 0 0 0 GO:0031663 6 lipopolysaccharide-mediated signaling pathway 19 20 1 0 0 0 0 0 52 20 2475 0.66093 1.0 1.0 0.0 0 0 0 0 0 GO:0032006 7 regulation of TOR signaling 19 20 1 1 0 0 0 0 52 20 2475 0.66093 1.0 1.0 0.0 0 0 0 0 0 GO:0032007 8 negative regulation of TOR signaling 11 11 1 1 0 0 0 0 52 11 2484 0.79664 1.0 1.0 0.0 0 0 0 0 0 GO:0032020 7 ISG15-protein conjugation 2 2 1 1 0 0 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:0032024 8 positive regulation of insulin secretion 27 29 1 1 0 1 0 0 52 29 2466 0.54796 1.0 1.0 0.0 0 0 0 0 0 GO:0032025 6 response to cobalt ion 13 13 1 1 1 0 0 0 52 13 2482 0.7643 1.0 1.0 0.0 0 0 0 0 0 GO:0032042 6 mitochondrial DNA metabolic process 5 5 1 1 0 0 0 0 52 5 2490 0.90193 1.0 1.0 0.0 0 0 0 0 0 GO:0032055 8 negative regulation of translation in response to stress 3 3 1 1 0 0 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:0032091 6 negative regulation of protein binding 41 42 2 2 1 1 0 0 52 42 2453 0.4175 1.0 1.0 0.0 0 0 0 0 0 GO:0032102 6 negative regulation of response to external stimulus 106 114 4 4 0 2 0 0 52 114 2381 0.090187 1.0 0.1705 0.0 0 0 0 0 0 GO:0032200 7 telomere organization 14 16 1 1 0 1 0 0 52 16 2479 0.71819 1.0 1.0 0.0 0 0 0 0 0 GO:0032204 5 regulation of telomere maintenance 18 18 2 1 1 0 0 0 52 18 2477 0.68897 1.0 1.0 0.0 0 0 0 0 0 GO:0032206 6 positive regulation of telomere maintenance 13 13 1 0 0 0 0 0 52 13 2482 0.7643 1.0 1.0 0.0 0 0 0 0 0 GO:0032231 6 regulation of actin filament bundle assembly 27 30 1 1 0 1 0 0 52 30 2465 0.53665 1.0 1.0 0.0 0 0 0 0 0 GO:0032233 7 positive regulation of actin filament bundle assembly 21 24 1 1 0 1 0 0 52 24 2471 0.60815 1.0 1.0 0.0 0 0 0 0 0 GO:0032259 3 methylation 34 41 2 2 0 2 0 0 52 41 2454 0.42634 1.0 1.0 0.0 0 0 0 0 0 GO:0032271 7 regulation of protein polymerization 48 52 1 1 0 0 0 0 52 52 2443 0.33837 1.0 0.62564 0.0 0 0 0 0 0 GO:0032273 8 positive regulation of protein polymerization 27 30 1 1 0 0 0 0 52 30 2465 0.53665 1.0 1.0 0.0 0 0 0 0 0 GO:0032370 6 positive regulation of lipid transport 26 28 1 1 0 1 0 0 52 28 2467 0.55952 1.0 1.0 0.0 0 0 0 0 0 GO:0032373 7 positive regulation of sterol transport 12 12 1 1 0 1 0 0 52 12 2483 0.7803 1.0 1.0 0.0 0 0 0 0 0 GO:0032376 8 positive regulation of cholesterol transport 12 12 1 1 0 1 0 0 52 12 2483 0.7803 1.0 1.0 0.0 0 0 0 0 0 GO:0032386 6 regulation of intracellular transport 104 109 2 2 0 1 0 0 52 109 2386 0.10046 1.0 0.16941 0.0 0 0 0 0 0 GO:0032387 6 negative regulation of intracellular transport 21 23 1 1 0 0 0 0 52 23 2472 0.62094 1.0 1.0 0.0 0 0 0 0 0 GO:0032392 8 DNA geometric change 18 18 1 1 0 1 0 0 52 18 2477 0.68897 1.0 1.0 0.0 0 0 0 0 0 GO:0032445 9 fructose import 1 1 1 0 0 0 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:0032465 6 regulation of cytokinesis 27 28 1 1 0 1 0 0 52 28 2467 0.55952 1.0 1.0 0.0 0 0 0 0 0 GO:0032479 6 regulation of type I interferon production 21 21 1 0 0 0 0 0 52 21 2474 0.64733 1.0 1.0 0.0 0 0 0 0 0 GO:0032481 7 positive regulation of type I interferon production 16 16 1 0 0 0 0 0 52 16 2479 0.71819 1.0 1.0 0.0 0 0 0 0 0 GO:0032489 10 regulation of Cdc42 protein signal transduction 4 5 1 1 0 1 0 0 52 5 2490 0.90193 1.0 1.0 0.0 0 0 0 0 0 GO:0032508 9 DNA duplex unwinding 17 17 1 1 0 1 0 0 52 17 2478 0.70343 1.0 1.0 0.0 0 0 0 0 0 GO:0032535 5 regulation of cellular component size 54 60 1 1 0 0 0 0 52 60 2435 0.28583 1.0 0.63391 0.0 0 0 0 0 0 GO:0032570 5 response to progesterone 36 40 1 1 0 1 0 0 52 40 2455 0.43537 1.0 1.0 0.0 0 0 0 0 0 GO:0032613 6 interleukin-10 production 3 3 1 1 0 1 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:0032615 6 interleukin-12 production 2 2 1 1 0 1 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:0032648 7 regulation of interferon-beta production 16 16 1 0 0 0 0 0 52 16 2479 0.71819 1.0 1.0 0.0 0 0 0 0 0 GO:0032649 6 regulation of interferon-gamma production 23 26 1 1 0 0 0 0 52 26 2469 0.58334 1.0 1.0 0.0 0 0 0 0 0 GO:0032663 6 regulation of interleukin-2 production 17 18 1 1 0 0 0 0 52 18 2477 0.68897 1.0 1.0 0.0 0 0 0 0 0 GO:0032691 8 negative regulation of interleukin-1 beta production 6 6 1 1 0 1 0 0 52 6 2489 0.88348 1.0 1.0 0.0 0 0 0 0 0 GO:0032692 7 negative regulation of interleukin-1 production 9 9 1 1 0 1 0 0 52 9 2486 0.83032 1.0 1.0 0.0 0 0 0 0 0 GO:0032703 7 negative regulation of interleukin-2 production 7 7 1 1 0 0 0 0 52 7 2488 0.8654 1.0 1.0 0.0 0 0 0 0 0 GO:0032728 8 positive regulation of interferon-beta production 12 12 1 0 0 0 0 0 52 12 2483 0.7803 1.0 1.0 0.0 0 0 0 0 0 GO:0032814 7 regulation of natural killer cell activation 8 8 1 0 0 0 0 0 52 8 2487 0.84768 1.0 1.0 0.0 0 0 0 0 0 GO:0032816 8 positive regulation of natural killer cell activation 7 7 1 0 0 0 0 0 52 7 2488 0.8654 1.0 1.0 0.0 0 0 0 0 0 GO:0032872 7 regulation of stress-activated MAPK cascade 56 60 1 1 1 0 0 0 52 60 2435 0.28583 1.0 0.63391 0.0 0 0 0 0 0 GO:0032873 8 negative regulation of stress-activated MAPK cascade 7 7 1 1 1 0 0 0 52 7 2488 0.8654 1.0 1.0 0.0 0 0 0 0 0 GO:0032897 6 negative regulation of viral transcription 7 7 1 1 0 0 0 0 52 7 2488 0.8654 1.0 1.0 0.0 0 0 0 0 0 GO:0032933 9 SREBP signaling pathway 2 2 1 1 0 1 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:0032944 7 regulation of mononuclear cell proliferation 75 80 1 0 0 0 0 0 52 80 2415 0.18701 1.0 0.40963 0.0 0 0 0 0 0 GO:0032946 8 positive regulation of mononuclear cell proliferation 48 52 1 0 0 0 0 0 52 52 2443 0.33837 1.0 0.62564 0.0 0 0 0 0 0 GO:0032956 6 regulation of actin cytoskeleton organization 79 82 2 2 0 1 0 0 52 82 2413 0.1792 1.0 0.41273 0.0 0 0 0 0 0 GO:0032970 5 regulation of actin filament-based process 88 91 2 2 0 1 0 0 52 91 2404 0.14787 1.0 0.26052 0.0 0 0 0 0 0 GO:0032984 6 protein-containing complex disassembly 18 21 1 1 1 0 0 0 52 21 2474 0.64733 1.0 1.0 0.0 0 0 0 0 0 GO:0032986 7 protein-DNA complex disassembly 5 5 1 1 1 0 0 0 52 5 2490 0.90193 1.0 1.0 0.0 0 0 0 0 0 GO:0033014 6 tetrapyrrole biosynthetic process 8 8 1 1 1 0 0 0 52 8 2487 0.84768 1.0 1.0 0.0 0 0 0 0 0 GO:0033036 3 macromolecule localization 295 315 8 8 0 6 0 0 52 315 2180 9.6876E-4 1.0 0.0020217 0.0 0 0 0 0 0 GO:0033044 7 regulation of chromosome organization 75 76 5 4 1 1 0 0 52 76 2419 0.20362 1.0 0.40479 0.0 0 0 0 0 0 GO:0033045 6 regulation of sister chromatid segregation 20 21 1 1 0 0 0 0 52 21 2474 0.64733 1.0 1.0 0.0 0 0 0 0 0 GO:0033047 7 regulation of mitotic sister chromatid segregation 18 18 1 1 0 0 0 0 52 18 2477 0.68897 1.0 1.0 0.0 0 0 0 0 0 GO:0033143 6 regulation of intracellular steroid hormone receptor signaling pathway 20 20 1 0 0 0 0 0 52 20 2475 0.66093 1.0 1.0 0.0 0 0 0 0 0 GO:0033144 7 negative regulation of intracellular steroid hormone receptor signaling pathway 10 10 1 0 0 0 0 0 52 10 2485 0.81331 1.0 1.0 0.0 0 0 0 0 0 GO:0033157 7 regulation of intracellular protein transport 69 73 2 2 0 1 0 0 52 73 2422 0.21703 1.0 0.40246 0.0 0 0 0 0 0 GO:0033198 5 response to ATP 13 13 1 0 0 0 0 0 52 13 2482 0.7643 1.0 1.0 0.0 0 0 0 0 0 GO:0033209 7 tumor necrosis factor-mediated signaling pathway 17 18 1 1 0 1 0 0 52 18 2477 0.68897 1.0 1.0 0.0 0 0 0 0 0 GO:0033235 10 positive regulation of protein sumoylation 4 4 1 0 0 0 0 0 52 4 2491 0.92076 1.0 1.0 0.0 0 0 0 0 0 GO:0033238 6 regulation of cellular amine metabolic process 12 13 1 1 0 1 0 0 52 13 2482 0.7643 1.0 1.0 0.0 0 0 0 0 0 GO:0033239 7 negative regulation of cellular amine metabolic process 3 3 1 1 0 1 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:0033240 7 positive regulation of cellular amine metabolic process 5 6 1 1 0 1 0 0 52 6 2489 0.88348 1.0 1.0 0.0 0 0 0 0 0 GO:0033365 6 protein localization to organelle 115 123 3 3 0 2 0 0 52 123 2372 0.074226 1.0 0.17742 0.0 0 0 0 0 0 GO:0033383 6 geranyl diphosphate metabolic process 1 1 1 1 0 1 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:0033384 6 geranyl diphosphate biosynthetic process 1 1 1 1 0 1 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:0033499 8 galactose catabolic process via UDP-galactose 2 2 1 1 0 1 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:0033500 6 carbohydrate homeostasis 85 91 8 7 1 4 0 0 52 91 2404 0.14787 1.0 0.26052 0.0 0 0 0 0 0 GO:0033555 3 multicellular organismal response to stress 16 17 1 1 0 1 0 0 52 17 2478 0.70343 1.0 1.0 0.0 0 0 0 0 0 GO:0033561 5 regulation of water loss via skin 8 8 1 1 0 1 0 0 52 8 2487 0.84768 1.0 1.0 0.0 0 0 0 0 0 GO:0033627 4 cell adhesion mediated by integrin 7 7 1 1 0 0 0 0 52 7 2488 0.8654 1.0 1.0 0.0 0 0 0 0 0 GO:0033700 8 phospholipid efflux 5 5 1 1 0 1 0 0 52 5 2490 0.90193 1.0 1.0 0.0 0 0 0 0 0 GO:0033762 6 response to glucagon 17 18 4 3 1 2 0 0 52 18 2477 0.68897 1.0 1.0 0.0 0 0 0 0 0 GO:0033866 7 nucleoside bisphosphate biosynthetic process 15 17 1 0 0 0 0 0 52 17 2478 0.70343 1.0 1.0 0.0 0 0 0 0 0 GO:0033962 7 cytoplasmic mRNA processing body assembly 3 3 1 1 1 0 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:0034014 5 response to triglyceride 5 5 1 1 0 1 0 0 52 5 2490 0.90193 1.0 1.0 0.0 0 0 0 0 0 GO:0034030 8 ribonucleoside bisphosphate biosynthetic process 15 17 1 0 0 0 0 0 52 17 2478 0.70343 1.0 1.0 0.0 0 0 0 0 0 GO:0034033 7 purine nucleoside bisphosphate biosynthetic process 15 17 1 0 0 0 0 0 52 17 2478 0.70343 1.0 1.0 0.0 0 0 0 0 0 GO:0034086 4 maintenance of sister chromatid cohesion 2 2 1 1 0 0 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:0034088 5 maintenance of mitotic sister chromatid cohesion 2 2 1 1 0 0 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:0034114 7 regulation of heterotypic cell-cell adhesion 12 13 1 1 0 1 0 0 52 13 2482 0.7643 1.0 1.0 0.0 0 0 0 0 0 GO:0034115 8 negative regulation of heterotypic cell-cell adhesion 4 4 1 1 0 1 0 0 52 4 2491 0.92076 1.0 1.0 0.0 0 0 0 0 0 GO:0034198 6 cellular response to amino acid starvation 13 15 1 1 0 0 0 0 52 15 2480 0.73325 1.0 1.0 0.0 0 0 0 0 0 GO:0034214 8 protein hexamerization 2 4 1 1 0 1 0 0 52 4 2491 0.92076 1.0 1.0 0.0 0 0 0 0 0 GO:0034219 5 carbohydrate transmembrane transport 6 8 2 1 0 0 0 0 52 8 2487 0.84768 1.0 1.0 0.0 0 0 0 0 0 GO:0034249 7 negative regulation of cellular amide metabolic process 28 29 2 2 0 0 0 0 52 29 2466 0.54796 1.0 1.0 0.0 0 0 0 0 0 GO:0034330 5 cell junction organization 75 80 1 1 0 1 0 0 52 80 2415 0.18701 1.0 0.40963 0.0 0 0 0 0 0 GO:0034340 6 response to type I interferon 4 4 1 1 0 0 0 0 52 4 2491 0.92076 1.0 1.0 0.0 0 0 0 0 0 GO:0034341 6 response to interferon-gamma 44 47 3 3 2 0 0 0 52 47 2448 0.37589 1.0 1.0 0.0 0 0 0 0 0 GO:0034349 6 glial cell apoptotic process 8 9 1 1 0 0 0 0 52 9 2486 0.83032 1.0 1.0 0.0 0 0 0 0 0 GO:0034375 8 high-density lipoprotein particle remodeling 8 8 1 1 0 1 0 0 52 8 2487 0.84768 1.0 1.0 0.0 0 0 0 0 0 GO:0034377 7 plasma lipoprotein particle assembly 7 7 1 1 0 1 0 0 52 7 2488 0.8654 1.0 1.0 0.0 0 0 0 0 0 GO:0034380 8 high-density lipoprotein particle assembly 4 4 1 1 0 1 0 0 52 4 2491 0.92076 1.0 1.0 0.0 0 0 0 0 0 GO:0034433 6 steroid esterification 2 2 1 1 0 1 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:0034434 7 sterol esterification 2 2 1 1 0 1 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:0034435 8 cholesterol esterification 2 2 1 1 0 1 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:0034440 5 lipid oxidation 39 43 1 1 0 0 0 0 52 43 2452 0.40883 1.0 1.0 0.0 0 0 0 0 0 GO:0034502 7 protein localization to chromosome 20 22 2 2 0 1 0 0 52 22 2473 0.634 1.0 1.0 0.0 0 0 0 0 0 GO:0034613 5 cellular protein localization 184 195 3 3 0 2 0 0 52 195 2300 0.015213 1.0 0.030559 0.0 0 0 0 0 0 GO:0034637 5 cellular carbohydrate biosynthetic process 15 17 1 1 0 1 0 0 52 17 2478 0.70343 1.0 1.0 0.0 0 0 0 0 0 GO:0034644 7 cellular response to UV 32 34 1 1 1 0 0 0 52 34 2461 0.49363 1.0 1.0 0.0 0 0 0 0 0 GO:0034655 5 nucleobase-containing compound catabolic process 33 39 2 2 1 0 0 0 52 39 2456 0.44459 1.0 1.0 0.0 0 0 0 0 0 GO:0034694 5 response to prostaglandin 15 16 1 0 0 0 0 0 52 16 2479 0.71819 1.0 1.0 0.0 0 0 0 0 0 GO:0034695 6 response to prostaglandin E 12 13 1 0 0 0 0 0 52 13 2482 0.7643 1.0 1.0 0.0 0 0 0 0 0 GO:0035023 9 regulation of Rho protein signal transduction 18 19 1 1 0 1 0 0 52 19 2476 0.67481 1.0 1.0 0.0 0 0 0 0 0 GO:0035025 10 positive regulation of Rho protein signal transduction 9 9 1 1 0 1 0 0 52 9 2486 0.83032 1.0 1.0 0.0 0 0 0 0 0 GO:0035150 5 regulation of tube size 54 57 2 2 0 1 0 0 52 57 2438 0.30452 1.0 0.62993 0.0 0 0 0 0 0 GO:0035264 3 multicellular organism growth 16 17 1 1 0 1 0 0 52 17 2478 0.70343 1.0 1.0 0.0 0 0 0 0 0 GO:0035278 10 miRNA mediated inhibition of translation 2 2 1 1 0 0 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:0035296 6 regulation of tube diameter 54 57 2 2 0 1 0 0 52 57 2438 0.30452 1.0 0.62993 0.0 0 0 0 0 0 GO:0035306 9 positive regulation of dephosphorylation 19 21 1 1 0 1 0 0 52 21 2474 0.64733 1.0 1.0 0.0 0 0 0 0 0 GO:0035376 8 sterol import 4 4 1 1 0 1 0 0 52 4 2491 0.92076 1.0 1.0 0.0 0 0 0 0 0 GO:0035384 5 thioester biosynthetic process 11 13 1 0 0 0 0 0 52 13 2482 0.7643 1.0 1.0 0.0 0 0 0 0 0 GO:0035404 9 histone-serine phosphorylation 5 5 1 1 0 1 0 0 52 5 2490 0.90193 1.0 1.0 0.0 0 0 0 0 0 GO:0035455 6 response to interferon-alpha 11 11 1 1 1 0 0 0 52 11 2484 0.79664 1.0 1.0 0.0 0 0 0 0 0 GO:0035457 7 cellular response to interferon-alpha 7 7 1 1 1 0 0 0 52 7 2488 0.8654 1.0 1.0 0.0 0 0 0 0 0 GO:0035592 5 establishment of protein localization to extracellular region 27 29 1 1 0 0 0 0 52 29 2466 0.54796 1.0 1.0 0.0 0 0 0 0 0 GO:0035666 8 TRIF-dependent toll-like receptor signaling pathway 3 3 1 0 0 0 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:0035774 7 positive regulation of insulin secretion involved in cellular response to glucose stimulus 13 13 1 1 0 1 0 0 52 13 2482 0.7643 1.0 1.0 0.0 0 0 0 0 0 GO:0035813 5 regulation of renal sodium excretion 6 7 1 1 0 1 0 0 52 7 2488 0.8654 1.0 1.0 0.0 0 0 0 0 0 GO:0035814 5 negative regulation of renal sodium excretion 2 3 1 1 0 1 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:0035821 3 modulation of process of other organism 40 42 1 1 1 0 0 0 52 42 2453 0.4175 1.0 1.0 0.0 0 0 0 0 0 GO:0035873 7 lactate transmembrane transport 2 2 1 1 1 0 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:0035879 8 plasma membrane lactate transport 2 2 1 1 1 0 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:0035900 4 response to isolation stress 6 6 1 1 0 1 0 0 52 6 2489 0.88348 1.0 1.0 0.0 0 0 0 0 0 GO:0035973 7 aggrephagy 1 1 1 1 0 1 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:0036490 8 regulation of translation in response to endoplasmic reticulum stress 3 4 1 1 0 0 0 0 52 4 2491 0.92076 1.0 1.0 0.0 0 0 0 0 0 GO:0036503 6 ERAD pathway 13 13 1 1 0 0 0 0 52 13 2482 0.7643 1.0 1.0 0.0 0 0 0 0 0 GO:0038034 5 signal transduction in absence of ligand 22 22 1 1 0 1 0 0 52 22 2473 0.634 1.0 1.0 0.0 0 0 0 0 0 GO:0038066 10 p38MAPK cascade 3 3 1 1 0 0 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:0040007 2 growth 94 98 4 4 1 3 0 0 52 98 2397 0.12727 1.0 0.26475 0.0 0 0 0 0 0 GO:0040014 5 regulation of multicellular organism growth 21 24 1 1 0 1 0 0 52 24 2471 0.60815 1.0 1.0 0.0 0 0 0 0 0 GO:0040033 9 negative regulation of translation, ncRNA-mediated 2 2 1 1 0 0 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:0042036 7 negative regulation of cytokine biosynthetic process 9 9 1 1 0 0 0 0 52 9 2486 0.83032 1.0 1.0 0.0 0 0 0 0 0 GO:0042053 7 regulation of dopamine metabolic process 8 9 1 1 0 1 0 0 52 9 2486 0.83032 1.0 1.0 0.0 0 0 0 0 0 GO:0042069 6 regulation of catecholamine metabolic process 8 9 1 1 0 1 0 0 52 9 2486 0.83032 1.0 1.0 0.0 0 0 0 0 0 GO:0042116 5 macrophage activation 23 24 1 0 0 0 0 0 52 24 2471 0.60815 1.0 1.0 0.0 0 0 0 0 0 GO:0042133 4 neurotransmitter metabolic process 31 35 4 4 1 3 0 0 52 35 2460 0.48342 1.0 1.0 0.0 0 0 0 0 0 GO:0042135 5 neurotransmitter catabolic process 7 8 1 1 0 1 0 0 52 8 2487 0.84768 1.0 1.0 0.0 0 0 0 0 0 GO:0042136 5 neurotransmitter biosynthetic process 14 17 1 1 1 0 0 0 52 17 2478 0.70343 1.0 1.0 0.0 0 0 0 0 0 GO:0042157 5 lipoprotein metabolic process 11 11 1 1 0 1 0 0 52 11 2484 0.79664 1.0 1.0 0.0 0 0 0 0 0 GO:0042158 6 lipoprotein biosynthetic process 3 3 1 1 0 1 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:0042168 5 heme metabolic process 11 11 1 1 1 0 0 0 52 11 2484 0.79664 1.0 1.0 0.0 0 0 0 0 0 GO:0042177 7 negative regulation of protein catabolic process 37 38 1 1 0 0 0 0 52 38 2457 0.454 1.0 1.0 0.0 0 0 0 0 0 GO:0042180 4 cellular ketone metabolic process 23 27 2 2 0 2 0 0 52 27 2468 0.5713 1.0 1.0 0.0 0 0 0 0 0 GO:0042246 4 tissue regeneration 26 26 1 1 1 0 0 0 52 26 2469 0.58334 1.0 1.0 0.0 0 0 0 0 0 GO:0042278 6 purine nucleoside metabolic process 9 11 1 1 0 1 0 0 52 11 2484 0.79664 1.0 1.0 0.0 0 0 0 0 0 GO:0042310 8 vasoconstriction 6 7 1 1 0 1 0 0 52 7 2488 0.8654 1.0 1.0 0.0 0 0 0 0 0 GO:0042311 8 vasodilation 12 13 1 1 0 1 0 0 52 13 2482 0.7643 1.0 1.0 0.0 0 0 0 0 0 GO:0042391 4 regulation of membrane potential 94 95 3 3 2 1 0 0 52 95 2400 0.13573 1.0 0.2623 0.0 0 0 0 0 0 GO:0042401 7 cellular biogenic amine biosynthetic process 2 3 1 1 1 0 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:0042417 5 dopamine metabolic process 10 12 1 1 0 1 0 0 52 12 2483 0.7803 1.0 1.0 0.0 0 0 0 0 0 GO:0042420 6 dopamine catabolic process 3 3 1 1 0 1 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:0042423 7 catecholamine biosynthetic process 8 8 1 1 1 0 0 0 52 8 2487 0.84768 1.0 1.0 0.0 0 0 0 0 0 GO:0042424 7 catecholamine catabolic process 3 3 1 1 0 1 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:0042440 3 pigment metabolic process 14 19 1 1 1 0 0 0 52 19 2476 0.67481 1.0 1.0 0.0 0 0 0 0 0 GO:0042446 5 hormone biosynthetic process 12 15 1 1 0 1 0 0 52 15 2480 0.73325 1.0 1.0 0.0 0 0 0 0 0 GO:0042474 5 middle ear morphogenesis 4 4 1 1 1 0 0 0 52 4 2491 0.92076 1.0 1.0 0.0 0 0 0 0 0 GO:0042534 7 regulation of tumor necrosis factor biosynthetic process 17 18 1 1 0 0 0 0 52 18 2477 0.68897 1.0 1.0 0.0 0 0 0 0 0 GO:0042551 5 neuron maturation 8 8 1 1 0 0 0 0 52 8 2487 0.84768 1.0 1.0 0.0 0 0 0 0 0 GO:0042593 7 glucose homeostasis 85 91 8 7 1 4 0 0 52 91 2404 0.14787 1.0 0.26052 0.0 0 0 0 0 0 GO:0042692 5 muscle cell differentiation 29 30 1 1 0 0 0 0 52 30 2465 0.53665 1.0 1.0 0.0 0 0 0 0 0 GO:0042742 5 defense response to bacterium 57 66 3 3 1 1 0 0 52 66 2429 0.25176 1.0 0.64443 0.0 0 0 0 0 0 GO:0042754 5 negative regulation of circadian rhythm 3 3 1 0 0 0 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:0042770 6 signal transduction in response to DNA damage 22 24 2 2 0 1 0 0 52 24 2471 0.60815 1.0 1.0 0.0 0 0 0 0 0 GO:0042789 8 mRNA transcription by RNA polymerase II 6 6 1 1 0 1 0 0 52 6 2489 0.88348 1.0 1.0 0.0 0 0 0 0 0 GO:0042866 8 pyruvate biosynthetic process 2 2 1 0 0 0 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:0042886 6 amide transport 189 201 2 2 0 1 0 0 52 201 2294 0.013302 1.0 0.031742 0.0 0 0 0 0 0 GO:0043009 6 chordate embryonic development 65 67 2 2 1 1 0 0 52 67 2428 0.24648 1.0 0.64646 0.0 0 0 0 0 0 GO:0043087 6 regulation of GTPase activity 76 81 1 1 0 0 0 0 52 81 2414 0.18306 1.0 0.41112 0.0 0 0 0 0 0 GO:0043094 4 cellular metabolic compound salvage 7 9 1 1 0 1 0 0 52 9 2486 0.83032 1.0 1.0 0.0 0 0 0 0 0 GO:0043102 6 amino acid salvage 4 4 1 1 0 1 0 0 52 4 2491 0.92076 1.0 1.0 0.0 0 0 0 0 0 GO:0043122 7 regulation of I-kappaB kinase/NF-kappaB signaling 56 62 2 1 0 1 0 0 52 62 2433 0.274 1.0 0.63707 0.0 0 0 0 0 0 GO:0043123 8 positive regulation of I-kappaB kinase/NF-kappaB signaling 42 47 1 0 0 0 0 0 52 47 2448 0.37589 1.0 1.0 0.0 0 0 0 0 0 GO:0043201 6 response to leucine 5 5 1 1 0 0 0 0 52 5 2490 0.90193 1.0 1.0 0.0 0 0 0 0 0 GO:0043249 5 erythrocyte maturation 1 1 1 1 0 1 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:0043254 6 regulation of protein-containing complex assembly 110 120 2 1 0 0 0 0 52 120 2375 0.079211 1.0 0.17444 0.0 0 0 0 0 0 GO:0043280 9 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process 44 47 1 1 1 0 0 0 52 47 2448 0.37589 1.0 1.0 0.0 0 0 0 0 0 GO:0043281 8 regulation of cysteine-type endopeptidase activity involved in apoptotic process 84 87 1 1 1 0 0 0 52 87 2408 0.16107 1.0 0.26054 0.0 0 0 0 0 0 GO:0043330 6 response to exogenous dsRNA 12 13 1 0 0 0 0 0 52 13 2482 0.7643 1.0 1.0 0.0 0 0 0 0 0 GO:0043331 5 response to dsRNA 17 18 1 0 0 0 0 0 52 18 2477 0.68897 1.0 1.0 0.0 0 0 0 0 0 GO:0043388 6 positive regulation of DNA binding 21 22 2 2 1 0 0 0 52 22 2473 0.634 1.0 1.0 0.0 0 0 0 0 0 GO:0043401 6 steroid hormone mediated signaling pathway 34 37 1 1 0 1 0 0 52 37 2458 0.46361 1.0 1.0 0.0 0 0 0 0 0 GO:0043409 8 negative regulation of MAPK cascade 47 51 1 1 1 0 0 0 52 51 2444 0.34556 1.0 0.62518 0.0 0 0 0 0 0 GO:0043414 4 macromolecule methylation 28 34 1 1 0 1 0 0 52 34 2461 0.49363 1.0 1.0 0.0 0 0 0 0 0 GO:0043457 7 regulation of cellular respiration 16 17 1 1 1 0 0 0 52 17 2478 0.70343 1.0 1.0 0.0 0 0 0 0 0 GO:0043470 6 regulation of carbohydrate catabolic process 24 25 2 2 1 1 0 0 52 25 2470 0.59562 1.0 1.0 0.0 0 0 0 0 0 GO:0043473 2 pigmentation 14 14 1 1 1 0 0 0 52 14 2481 0.74861 1.0 1.0 0.0 0 0 0 0 0 GO:0043487 5 regulation of RNA stability 15 16 2 2 1 0 0 0 52 16 2479 0.71819 1.0 1.0 0.0 0 0 0 0 0 GO:0043488 6 regulation of mRNA stability 15 16 2 2 1 0 0 0 52 16 2479 0.71819 1.0 1.0 0.0 0 0 0 0 0 GO:0043489 6 RNA stabilization 10 10 2 2 1 0 0 0 52 10 2485 0.81331 1.0 1.0 0.0 0 0 0 0 0 GO:0043491 6 protein kinase B signaling 19 20 1 1 0 0 0 0 52 20 2475 0.66093 1.0 1.0 0.0 0 0 0 0 0 GO:0043502 5 regulation of muscle adaptation 33 33 3 3 0 3 0 0 52 33 2462 0.50406 1.0 1.0 0.0 0 0 0 0 0 GO:0043524 8 negative regulation of neuron apoptotic process 75 76 1 1 0 1 0 0 52 76 2419 0.20362 1.0 0.40479 0.0 0 0 0 0 0 GO:0043534 8 blood vessel endothelial cell migration 13 13 2 2 0 2 0 0 52 13 2482 0.7643 1.0 1.0 0.0 0 0 0 0 0 GO:0043542 7 endothelial cell migration 25 26 2 2 0 2 0 0 52 26 2469 0.58334 1.0 1.0 0.0 0 0 0 0 0 GO:0043543 7 protein acylation 23 23 1 1 0 1 0 0 52 23 2472 0.62094 1.0 1.0 0.0 0 0 0 0 0 GO:0043547 7 positive regulation of GTPase activity 63 68 1 1 0 0 0 0 52 68 2427 0.24132 1.0 0.40137 0.0 0 0 0 0 0 GO:0043550 7 regulation of lipid kinase activity 23 23 1 1 0 0 0 0 52 23 2472 0.62094 1.0 1.0 0.0 0 0 0 0 0 GO:0043555 7 regulation of translation in response to stress 7 8 1 1 0 0 0 0 52 8 2487 0.84768 1.0 1.0 0.0 0 0 0 0 0 GO:0043691 9 reverse cholesterol transport 7 7 1 1 0 1 0 0 52 7 2488 0.8654 1.0 1.0 0.0 0 0 0 0 0 GO:0043903 4 regulation of interspecies interactions between organisms 58 62 2 2 0 0 0 0 52 62 2433 0.274 1.0 0.63707 0.0 0 0 0 0 0 GO:0044003 5 modulation by symbiont of host process 13 14 1 1 1 0 0 0 52 14 2481 0.74861 1.0 1.0 0.0 0 0 0 0 0 GO:0044030 7 regulation of DNA methylation 9 9 1 1 1 0 0 0 52 9 2486 0.83032 1.0 1.0 0.0 0 0 0 0 0 GO:0044036 5 cell wall macromolecule metabolic process 1 1 1 1 1 0 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:0044042 6 glucan metabolic process 15 16 1 1 0 1 0 0 52 16 2479 0.71819 1.0 1.0 0.0 0 0 0 0 0 GO:0044062 6 regulation of excretion 6 7 1 1 0 1 0 0 52 7 2488 0.8654 1.0 1.0 0.0 0 0 0 0 0 GO:0044087 5 regulation of cellular component biogenesis 211 228 3 2 0 1 0 0 52 228 2267 0.0072374 1.0 0.012379 0.0 0 0 0 0 0 GO:0044089 6 positive regulation of cellular component biogenesis 110 121 2 2 0 1 0 0 52 121 2374 0.077514 1.0 0.17536 0.0 0 0 0 0 0 GO:0044106 5 cellular amine metabolic process 14 16 1 1 1 0 0 0 52 16 2479 0.71819 1.0 1.0 0.0 0 0 0 0 0 GO:0044247 6 cellular polysaccharide catabolic process 4 4 1 1 0 1 0 0 52 4 2491 0.92076 1.0 1.0 0.0 0 0 0 0 0 GO:0044262 4 cellular carbohydrate metabolic process 38 40 3 3 1 2 0 0 52 40 2455 0.43537 1.0 1.0 0.0 0 0 0 0 0 GO:0044264 5 cellular polysaccharide metabolic process 20 22 2 2 1 1 0 0 52 22 2473 0.634 1.0 1.0 0.0 0 0 0 0 0 GO:0044272 5 sulfur compound biosynthetic process 25 31 3 2 0 2 0 0 52 31 2464 0.52556 1.0 1.0 0.0 0 0 0 0 0 GO:0044275 5 cellular carbohydrate catabolic process 5 5 1 1 0 1 0 0 52 5 2490 0.90193 1.0 1.0 0.0 0 0 0 0 0 GO:0044336 9 canonical Wnt signaling pathway involved in negative regulation of apoptotic process 1 1 1 1 1 0 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:0044337 9 canonical Wnt signaling pathway involved in positive regulation of apoptotic process 1 1 1 1 1 0 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:0044344 6 cellular response to fibroblast growth factor stimulus 25 26 2 2 1 0 0 0 52 26 2469 0.58334 1.0 1.0 0.0 0 0 0 0 0 GO:0044380 7 protein localization to cytoskeleton 8 10 1 1 0 1 0 0 52 10 2485 0.81331 1.0 1.0 0.0 0 0 0 0 0 GO:0044403 3 symbiotic process 38 40 3 3 2 0 0 0 52 40 2455 0.43537 1.0 1.0 0.0 0 0 0 0 0 GO:0044406 3 adhesion of symbiont to host 7 7 2 2 1 0 0 0 52 7 2488 0.8654 1.0 1.0 0.0 0 0 0 0 0 GO:0044550 4 secondary metabolite biosynthetic process 1 2 1 1 0 1 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:0044597 5 daunorubicin metabolic process 1 1 1 1 0 1 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:0044598 4 doxorubicin metabolic process 1 1 1 1 0 1 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:0044650 4 adhesion of symbiont to host cell 2 2 1 1 0 0 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:0044752 6 response to human chorionic gonadotropin 6 6 1 1 1 0 0 0 52 6 2489 0.88348 1.0 1.0 0.0 0 0 0 0 0 GO:0045023 4 G0 to G1 transition 1 1 1 1 1 0 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:0045069 7 regulation of viral genome replication 22 24 1 1 0 0 0 0 52 24 2471 0.60815 1.0 1.0 0.0 0 0 0 0 0 GO:0045071 7 negative regulation of viral genome replication 17 18 1 1 0 0 0 0 52 18 2477 0.68897 1.0 1.0 0.0 0 0 0 0 0 GO:0045076 7 regulation of interleukin-2 biosynthetic process 7 7 1 1 0 0 0 0 52 7 2488 0.8654 1.0 1.0 0.0 0 0 0 0 0 GO:0045085 8 negative regulation of interleukin-2 biosynthetic process 2 2 1 1 0 0 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:0045123 6 cellular extravasation 6 7 1 1 0 0 0 0 52 7 2488 0.8654 1.0 1.0 0.0 0 0 0 0 0 GO:0045184 4 establishment of protein localization 190 203 2 2 0 1 0 0 52 203 2292 0.012718 1.0 0.019431 0.0 0 0 0 0 0 GO:0045333 5 cellular respiration 13 14 1 1 0 1 0 0 52 14 2481 0.74861 1.0 1.0 0.0 0 0 0 0 0 GO:0045337 6 farnesyl diphosphate biosynthetic process 4 4 1 1 0 1 0 0 52 4 2491 0.92076 1.0 1.0 0.0 0 0 0 0 0 GO:0045338 6 farnesyl diphosphate metabolic process 5 5 1 1 0 1 0 0 52 5 2490 0.90193 1.0 1.0 0.0 0 0 0 0 0 GO:0045357 7 regulation of interferon-beta biosynthetic process 5 5 1 0 0 0 0 0 52 5 2490 0.90193 1.0 1.0 0.0 0 0 0 0 0 GO:0045359 8 positive regulation of interferon-beta biosynthetic process 4 4 1 0 0 0 0 0 52 4 2491 0.92076 1.0 1.0 0.0 0 0 0 0 0 GO:0045428 5 regulation of nitric oxide biosynthetic process 33 36 2 1 0 0 0 0 52 36 2459 0.47341 1.0 1.0 0.0 0 0 0 0 0 GO:0045429 6 positive regulation of nitric oxide biosynthetic process 25 28 2 1 0 0 0 0 52 28 2467 0.55952 1.0 1.0 0.0 0 0 0 0 0 GO:0045445 5 myoblast differentiation 11 11 1 1 0 0 0 0 52 11 2484 0.79664 1.0 1.0 0.0 0 0 0 0 0 GO:0045540 7 regulation of cholesterol biosynthetic process 10 10 3 3 0 3 0 0 52 10 2485 0.81331 1.0 1.0 0.0 0 0 0 0 0 GO:0045542 8 positive regulation of cholesterol biosynthetic process 6 6 2 2 0 2 0 0 52 6 2489 0.88348 1.0 1.0 0.0 0 0 0 0 0 GO:0045604 6 regulation of epidermal cell differentiation 11 11 1 1 0 0 0 0 52 11 2484 0.79664 1.0 1.0 0.0 0 0 0 0 0 GO:0045616 7 regulation of keratinocyte differentiation 5 5 1 1 0 0 0 0 52 5 2490 0.90193 1.0 1.0 0.0 0 0 0 0 0 GO:0045647 6 negative regulation of erythrocyte differentiation 2 3 1 1 0 0 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:0045655 8 regulation of monocyte differentiation 7 7 1 1 1 0 0 0 52 7 2488 0.8654 1.0 1.0 0.0 0 0 0 0 0 GO:0045656 9 negative regulation of monocyte differentiation 3 3 1 1 1 0 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:0045721 7 negative regulation of gluconeogenesis 6 6 1 0 0 0 0 0 52 6 2489 0.88348 1.0 1.0 0.0 0 0 0 0 0 GO:0045723 8 positive regulation of fatty acid biosynthetic process 13 14 1 1 0 1 0 0 52 14 2481 0.74861 1.0 1.0 0.0 0 0 0 0 0 GO:0045727 8 positive regulation of translation 24 28 1 1 0 1 0 0 52 28 2467 0.55952 1.0 1.0 0.0 0 0 0 0 0 GO:0045744 7 negative regulation of G protein-coupled receptor signaling pathway 10 10 1 0 0 0 0 0 52 10 2485 0.81331 1.0 1.0 0.0 0 0 0 0 0 GO:0045764 7 positive regulation of cellular amino acid metabolic process 2 2 1 1 0 1 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:0045776 5 negative regulation of blood pressure 16 18 1 1 0 1 0 0 52 18 2477 0.68897 1.0 1.0 0.0 0 0 0 0 0 GO:0045785 6 positive regulation of cell adhesion 137 145 2 2 0 1 0 0 52 145 2350 0.045967 1.0 0.071904 0.0 0 0 0 0 0 GO:0045821 7 positive regulation of glycolytic process 11 12 2 2 1 1 0 0 52 12 2483 0.7803 1.0 1.0 0.0 0 0 0 0 0 GO:0045834 6 positive regulation of lipid metabolic process 76 82 5 5 1 4 0 0 52 82 2413 0.1792 1.0 0.41273 0.0 0 0 0 0 0 GO:0045838 5 positive regulation of membrane potential 8 8 1 1 1 0 0 0 52 8 2487 0.84768 1.0 1.0 0.0 0 0 0 0 0 GO:0045840 8 positive regulation of mitotic nuclear division 21 24 1 1 0 0 0 0 52 24 2471 0.60815 1.0 1.0 0.0 0 0 0 0 0 GO:0045842 9 positive regulation of mitotic metaphase/anaphase transition 3 3 1 1 0 0 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:0045843 7 negative regulation of striated muscle tissue development 21 21 1 1 0 1 0 0 52 21 2474 0.64733 1.0 1.0 0.0 0 0 0 0 0 GO:0045844 7 positive regulation of striated muscle tissue development 30 32 1 1 0 1 0 0 52 32 2463 0.5147 1.0 1.0 0.0 0 0 0 0 0 GO:0045879 7 negative regulation of smoothened signaling pathway 4 5 1 1 0 0 0 0 52 5 2490 0.90193 1.0 1.0 0.0 0 0 0 0 0 GO:0045907 7 positive regulation of vasoconstriction 19 20 1 1 0 0 0 0 52 20 2475 0.66093 1.0 1.0 0.0 0 0 0 0 0 GO:0045913 6 positive regulation of carbohydrate metabolic process 30 32 3 3 1 2 0 0 52 32 2463 0.5147 1.0 1.0 0.0 0 0 0 0 0 GO:0045914 7 negative regulation of catecholamine metabolic process 3 3 1 1 0 1 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:0045923 7 positive regulation of fatty acid metabolic process 25 26 1 1 0 1 0 0 52 26 2469 0.58334 1.0 1.0 0.0 0 0 0 0 0 GO:0045927 5 positive regulation of growth 71 75 2 2 1 1 0 0 52 75 2420 0.208 1.0 0.40388 0.0 0 0 0 0 0 GO:0045940 7 positive regulation of steroid metabolic process 23 25 3 3 0 3 0 0 52 25 2470 0.59562 1.0 1.0 0.0 0 0 0 0 0 GO:0045963 8 negative regulation of dopamine metabolic process 3 3 1 1 0 1 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:0045974 8 regulation of translation, ncRNA-mediated 2 2 1 1 0 0 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:0045981 7 positive regulation of nucleotide metabolic process 17 19 2 2 1 1 0 0 52 19 2476 0.67481 1.0 1.0 0.0 0 0 0 0 0 GO:0046031 8 ADP metabolic process 14 19 1 0 0 0 0 0 52 19 2476 0.67481 1.0 1.0 0.0 0 0 0 0 0 GO:0046034 3 ATP metabolic process 31 37 1 0 0 0 0 0 52 37 2458 0.46361 1.0 1.0 0.0 0 0 0 0 0 GO:0046128 7 purine ribonucleoside metabolic process 9 11 1 1 0 1 0 0 52 11 2484 0.79664 1.0 1.0 0.0 0 0 0 0 0 GO:0046148 4 pigment biosynthetic process 8 10 1 1 1 0 0 0 52 10 2485 0.81331 1.0 1.0 0.0 0 0 0 0 0 GO:0046168 6 glycerol-3-phosphate catabolic process 1 1 1 1 0 1 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:0046189 6 phenol-containing compound biosynthetic process 8 8 1 1 1 0 0 0 52 8 2487 0.84768 1.0 1.0 0.0 0 0 0 0 0 GO:0046323 9 glucose import 3 4 1 1 0 0 0 0 52 4 2491 0.92076 1.0 1.0 0.0 0 0 0 0 0 GO:0046325 8 negative regulation of glucose import 3 5 1 1 1 0 0 0 52 5 2490 0.90193 1.0 1.0 0.0 0 0 0 0 0 GO:0046327 8 glycerol biosynthetic process from pyruvate 2 2 1 1 0 1 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:0046364 5 monosaccharide biosynthetic process 13 16 4 3 0 3 0 0 52 16 2479 0.71819 1.0 1.0 0.0 0 0 0 0 0 GO:0046365 5 monosaccharide catabolic process 7 9 1 1 0 1 0 0 52 9 2486 0.83032 1.0 1.0 0.0 0 0 0 0 0 GO:0046390 6 ribose phosphate biosynthetic process 34 39 4 2 0 2 0 0 52 39 2456 0.44459 1.0 1.0 0.0 0 0 0 0 0 GO:0046391 6 5-phosphoribose 1-diphosphate metabolic process 1 1 1 1 0 1 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:0046398 6 UDP-glucuronate metabolic process 1 1 1 1 0 1 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:0046434 5 organophosphate catabolic process 16 20 1 1 0 1 0 0 52 20 2475 0.66093 1.0 1.0 0.0 0 0 0 0 0 GO:0046459 7 short-chain fatty acid metabolic process 7 7 1 1 0 1 0 0 52 7 2488 0.8654 1.0 1.0 0.0 0 0 0 0 0 GO:0046470 6 phosphatidylcholine metabolic process 13 15 2 2 0 2 0 0 52 15 2480 0.73325 1.0 1.0 0.0 0 0 0 0 0 GO:0046474 6 glycerophospholipid biosynthetic process 21 23 1 1 0 1 0 0 52 23 2472 0.62094 1.0 1.0 0.0 0 0 0 0 0 GO:0046485 5 ether lipid metabolic process 2 2 1 0 0 0 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:0046488 7 phosphatidylinositol metabolic process 26 28 1 1 0 1 0 0 52 28 2467 0.55952 1.0 1.0 0.0 0 0 0 0 0 GO:0046496 7 nicotinamide nucleotide metabolic process 7 7 1 1 0 1 0 0 52 7 2488 0.8654 1.0 1.0 0.0 0 0 0 0 0 GO:0046498 6 S-adenosylhomocysteine metabolic process 4 4 1 1 0 1 0 0 52 4 2491 0.92076 1.0 1.0 0.0 0 0 0 0 0 GO:0046500 4 S-adenosylmethionine metabolic process 6 7 2 2 0 2 0 0 52 7 2488 0.8654 1.0 1.0 0.0 0 0 0 0 0 GO:0046501 6 protoporphyrinogen IX metabolic process 4 4 1 1 1 0 0 0 52 4 2491 0.92076 1.0 1.0 0.0 0 0 0 0 0 GO:0046504 5 glycerol ether biosynthetic process 1 1 1 0 0 0 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:0046578 8 regulation of Ras protein signal transduction 34 36 1 1 0 1 0 0 52 36 2459 0.47341 1.0 1.0 0.0 0 0 0 0 0 GO:0046579 9 positive regulation of Ras protein signal transduction 15 16 1 1 0 1 0 0 52 16 2479 0.71819 1.0 1.0 0.0 0 0 0 0 0 GO:0046620 5 regulation of organ growth 36 37 2 2 0 2 0 0 52 37 2458 0.46361 1.0 1.0 0.0 0 0 0 0 0 GO:0046621 6 negative regulation of organ growth 14 14 1 1 0 1 0 0 52 14 2481 0.74861 1.0 1.0 0.0 0 0 0 0 0 GO:0046622 6 positive regulation of organ growth 17 18 1 1 0 1 0 0 52 18 2477 0.68897 1.0 1.0 0.0 0 0 0 0 0 GO:0046676 8 negative regulation of insulin secretion 10 11 1 1 0 1 0 0 52 11 2484 0.79664 1.0 1.0 0.0 0 0 0 0 0 GO:0046687 5 response to chromate 3 3 1 1 0 1 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:0046722 7 lactic acid secretion 1 1 1 1 1 0 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:0046782 6 regulation of viral transcription 13 13 1 1 0 0 0 0 52 13 2482 0.7643 1.0 1.0 0.0 0 0 0 0 0 GO:0046813 6 receptor-mediated virion attachment to host cell 1 1 1 1 0 0 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:0046887 6 positive regulation of hormone secretion 46 50 2 2 1 1 0 0 52 50 2445 0.35291 1.0 0.62487 0.0 0 0 0 0 0 GO:0046889 7 positive regulation of lipid biosynthetic process 46 50 4 4 0 4 0 0 52 50 2445 0.35291 1.0 0.62487 0.0 0 0 0 0 0 GO:0046898 5 response to cycloheximide 7 8 1 1 1 0 0 0 52 8 2487 0.84768 1.0 1.0 0.0 0 0 0 0 0 GO:0046907 4 intracellular transport 174 183 1 1 0 1 0 0 52 183 2312 0.01988 1.0 0.049652 0.0 0 0 0 0 0 GO:0046916 9 cellular transition metal ion homeostasis 20 23 2 2 1 1 0 0 52 23 2472 0.62094 1.0 1.0 0.0 0 0 0 0 0 GO:0046939 7 nucleotide phosphorylation 14 19 2 1 0 1 0 0 52 19 2476 0.67481 1.0 1.0 0.0 0 0 0 0 0 GO:0047496 6 vesicle transport along microtubule 6 6 1 1 0 1 0 0 52 6 2489 0.88348 1.0 1.0 0.0 0 0 0 0 0 GO:0048015 7 phosphatidylinositol-mediated signaling 19 20 1 1 1 0 0 0 52 20 2475 0.66093 1.0 1.0 0.0 0 0 0 0 0 GO:0048017 6 inositol lipid-mediated signaling 19 20 1 1 1 0 0 0 52 20 2475 0.66093 1.0 1.0 0.0 0 0 0 0 0 GO:0048145 6 regulation of fibroblast proliferation 37 41 1 1 1 0 0 0 52 41 2454 0.42634 1.0 1.0 0.0 0 0 0 0 0 GO:0048146 7 positive regulation of fibroblast proliferation 27 30 1 1 1 0 0 0 52 30 2465 0.53665 1.0 1.0 0.0 0 0 0 0 0 GO:0048147 7 negative regulation of fibroblast proliferation 11 11 1 1 1 0 0 0 52 11 2484 0.79664 1.0 1.0 0.0 0 0 0 0 0 GO:0048240 4 sperm capacitation 5 5 1 1 1 0 0 0 52 5 2490 0.90193 1.0 1.0 0.0 0 0 0 0 0 GO:0048252 8 lauric acid metabolic process 3 4 1 1 1 0 0 0 52 4 2491 0.92076 1.0 1.0 0.0 0 0 0 0 0 GO:0048255 7 mRNA stabilization 10 10 2 2 1 0 0 0 52 10 2485 0.81331 1.0 1.0 0.0 0 0 0 0 0 GO:0048265 4 response to pain 2 2 1 1 0 1 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:0048285 6 organelle fission 20 20 1 1 0 0 0 0 52 20 2475 0.66093 1.0 1.0 0.0 0 0 0 0 0 GO:0048489 6 synaptic vesicle transport 8 8 1 1 0 1 0 0 52 8 2487 0.84768 1.0 1.0 0.0 0 0 0 0 0 GO:0048490 8 anterograde synaptic vesicle transport 2 2 1 1 0 1 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:0048525 5 negative regulation of viral process 30 32 2 2 0 0 0 0 52 32 2463 0.5147 1.0 1.0 0.0 0 0 0 0 0 GO:0048588 4 developmental cell growth 20 23 1 1 0 1 0 0 52 23 2472 0.62094 1.0 1.0 0.0 0 0 0 0 0 GO:0048589 3 developmental growth 91 95 4 4 1 3 0 0 52 95 2400 0.13573 1.0 0.2623 0.0 0 0 0 0 0 GO:0048634 6 regulation of muscle organ development 56 58 3 3 0 3 0 0 52 58 2437 0.29816 1.0 0.63115 0.0 0 0 0 0 0 GO:0048635 6 negative regulation of muscle organ development 22 22 1 1 0 1 0 0 52 22 2473 0.634 1.0 1.0 0.0 0 0 0 0 0 GO:0048636 6 positive regulation of muscle organ development 30 32 1 1 0 1 0 0 52 32 2463 0.5147 1.0 1.0 0.0 0 0 0 0 0 GO:0048638 5 regulation of developmental growth 94 100 2 2 0 2 0 0 52 100 2395 0.12192 1.0 0.26688 0.0 0 0 0 0 0 GO:0048639 6 positive regulation of developmental growth 48 50 1 1 0 1 0 0 52 50 2445 0.35291 1.0 0.62487 0.0 0 0 0 0 0 GO:0048640 6 negative regulation of developmental growth 30 32 1 1 0 1 0 0 52 32 2463 0.5147 1.0 1.0 0.0 0 0 0 0 0 GO:0048641 7 regulation of skeletal muscle tissue development 18 18 1 1 0 1 0 0 52 18 2477 0.68897 1.0 1.0 0.0 0 0 0 0 0 GO:0048705 5 skeletal system morphogenesis 20 21 1 1 1 0 0 0 52 21 2474 0.64733 1.0 1.0 0.0 0 0 0 0 0 GO:0048733 6 sebaceous gland development 2 3 1 1 0 1 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:0048741 8 skeletal muscle fiber development 7 7 1 1 1 0 0 0 52 7 2488 0.8654 1.0 1.0 0.0 0 0 0 0 0 GO:0048747 7 muscle fiber development 18 18 1 1 1 0 0 0 52 18 2477 0.68897 1.0 1.0 0.0 0 0 0 0 0 GO:0048821 6 erythrocyte development 8 9 2 2 1 1 0 0 52 9 2486 0.83032 1.0 1.0 0.0 0 0 0 0 0 GO:0048854 5 brain morphogenesis 6 6 1 1 0 1 0 0 52 6 2489 0.88348 1.0 1.0 0.0 0 0 0 0 0 GO:0048872 5 homeostasis of number of cells 46 48 1 1 0 1 0 0 52 48 2447 0.36808 1.0 0.62471 0.0 0 0 0 0 0 GO:0048873 6 homeostasis of number of cells within a tissue 12 12 1 1 0 1 0 0 52 12 2483 0.7803 1.0 1.0 0.0 0 0 0 0 0 GO:0050657 7 nucleic acid transport 18 20 1 1 0 0 0 0 52 20 2475 0.66093 1.0 1.0 0.0 0 0 0 0 0 GO:0050658 5 RNA transport 18 20 1 1 0 0 0 0 52 20 2475 0.66093 1.0 1.0 0.0 0 0 0 0 0 GO:0050663 6 cytokine secretion 13 15 1 1 0 0 0 0 52 15 2480 0.73325 1.0 1.0 0.0 0 0 0 0 0 GO:0050666 8 regulation of homocysteine metabolic process 1 1 1 1 0 1 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:0050668 9 positive regulation of homocysteine metabolic process 1 1 1 1 0 1 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:0050670 7 regulation of lymphocyte proliferation 73 78 1 0 0 0 0 0 52 78 2417 0.19514 1.0 0.40697 0.0 0 0 0 0 0 GO:0050671 8 positive regulation of lymphocyte proliferation 47 51 1 0 0 0 0 0 52 51 2444 0.34556 1.0 0.62518 0.0 0 0 0 0 0 GO:0050680 7 negative regulation of epithelial cell proliferation 40 44 1 1 0 0 0 0 52 44 2451 0.40034 1.0 1.0 0.0 0 0 0 0 0 GO:0050709 7 negative regulation of protein secretion 32 34 2 2 0 2 0 0 52 34 2461 0.49363 1.0 1.0 0.0 0 0 0 0 0 GO:0050710 6 negative regulation of cytokine secretion 13 14 1 1 0 1 0 0 52 14 2481 0.74861 1.0 1.0 0.0 0 0 0 0 0 GO:0050711 7 negative regulation of interleukin-1 secretion 3 3 1 1 0 1 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:0050713 8 negative regulation of interleukin-1 beta secretion 2 2 1 1 0 1 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:0050728 7 negative regulation of inflammatory response 47 48 4 4 0 2 0 0 52 48 2447 0.36808 1.0 0.62471 0.0 0 0 0 0 0 GO:0050730 9 regulation of peptidyl-tyrosine phosphorylation 89 95 2 2 1 0 0 0 52 95 2400 0.13573 1.0 0.2623 0.0 0 0 0 0 0 GO:0050731 10 positive regulation of peptidyl-tyrosine phosphorylation 66 72 1 1 0 0 0 0 52 72 2423 0.22169 1.0 0.40196 0.0 0 0 0 0 0 GO:0050732 10 negative regulation of peptidyl-tyrosine phosphorylation 24 24 1 1 1 0 0 0 52 24 2471 0.60815 1.0 1.0 0.0 0 0 0 0 0 GO:0050764 6 regulation of phagocytosis 46 51 1 1 0 1 0 0 52 51 2444 0.34556 1.0 0.62518 0.0 0 0 0 0 0 GO:0050766 6 positive regulation of phagocytosis 30 35 1 1 0 1 0 0 52 35 2460 0.48342 1.0 1.0 0.0 0 0 0 0 0 GO:0050773 9 regulation of dendrite development 40 44 1 1 0 1 0 0 52 44 2451 0.40034 1.0 1.0 0.0 0 0 0 0 0 GO:0050777 6 negative regulation of immune response 45 49 1 1 0 1 0 0 52 49 2446 0.36042 1.0 0.62471 0.0 0 0 0 0 0 GO:0050779 6 RNA destabilization 2 2 1 1 0 0 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:0050792 5 regulation of viral process 53 56 2 2 0 0 0 0 52 56 2439 0.31101 1.0 0.62883 0.0 0 0 0 0 0 GO:0050796 7 regulation of insulin secretion 45 50 2 2 0 2 0 0 52 50 2445 0.35291 1.0 0.62487 0.0 0 0 0 0 0 GO:0050808 6 synapse organization 39 44 1 1 0 1 0 0 52 44 2451 0.40034 1.0 1.0 0.0 0 0 0 0 0 GO:0050812 7 regulation of acyl-CoA biosynthetic process 3 3 1 1 0 1 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:0050830 6 defense response to Gram-positive bacterium 27 33 2 2 1 1 0 0 52 33 2462 0.50406 1.0 1.0 0.0 0 0 0 0 0 GO:0050867 6 positive regulation of cell activation 103 110 1 0 0 0 0 0 52 110 2385 0.098318 1.0 0.16946 0.0 0 0 0 0 0 GO:0050871 8 positive regulation of B cell activation 27 29 1 0 0 0 0 0 52 29 2466 0.54796 1.0 1.0 0.0 0 0 0 0 0 GO:0050872 6 white fat cell differentiation 4 4 1 1 0 1 0 0 52 4 2491 0.92076 1.0 1.0 0.0 0 0 0 0 0 GO:0050873 6 brown fat cell differentiation 15 17 1 1 0 1 0 0 52 17 2478 0.70343 1.0 1.0 0.0 0 0 0 0 0 GO:0050891 4 multicellular organismal water homeostasis 11 11 1 1 0 1 0 0 52 11 2484 0.79664 1.0 1.0 0.0 0 0 0 0 0 GO:0050906 4 detection of stimulus involved in sensory perception 21 22 1 1 1 0 0 0 52 22 2473 0.634 1.0 1.0 0.0 0 0 0 0 0 GO:0050910 5 detection of mechanical stimulus involved in sensory perception of sound 4 4 1 1 1 0 0 0 52 4 2491 0.92076 1.0 1.0 0.0 0 0 0 0 0 GO:0050919 5 negative chemotaxis 5 5 1 1 0 1 0 0 52 5 2490 0.90193 1.0 1.0 0.0 0 0 0 0 0 GO:0050954 6 sensory perception of mechanical stimulus 27 27 1 1 0 0 0 0 52 27 2468 0.5713 1.0 1.0 0.0 0 0 0 0 0 GO:0050974 5 detection of mechanical stimulus involved in sensory perception 15 16 1 1 1 0 0 0 52 16 2479 0.71819 1.0 1.0 0.0 0 0 0 0 0 GO:0050982 5 detection of mechanical stimulus 19 20 1 1 1 0 0 0 52 20 2475 0.66093 1.0 1.0 0.0 0 0 0 0 0 GO:0050994 6 regulation of lipid catabolic process 22 26 3 3 1 2 0 0 52 26 2469 0.58334 1.0 1.0 0.0 0 0 0 0 0 GO:0050995 7 negative regulation of lipid catabolic process 10 11 1 1 0 1 0 0 52 11 2484 0.79664 1.0 1.0 0.0 0 0 0 0 0 GO:0050996 7 positive regulation of lipid catabolic process 13 15 2 2 1 1 0 0 52 15 2480 0.73325 1.0 1.0 0.0 0 0 0 0 0 GO:0051004 7 regulation of lipoprotein lipase activity 8 8 1 1 0 1 0 0 52 8 2487 0.84768 1.0 1.0 0.0 0 0 0 0 0 GO:0051006 8 positive regulation of lipoprotein lipase activity 5 5 1 1 0 1 0 0 52 5 2490 0.90193 1.0 1.0 0.0 0 0 0 0 0 GO:0051028 6 mRNA transport 14 15 1 1 0 0 0 0 52 15 2480 0.73325 1.0 1.0 0.0 0 0 0 0 0 GO:0051043 7 regulation of membrane protein ectodomain proteolysis 10 11 1 1 0 1 0 0 52 11 2484 0.79664 1.0 1.0 0.0 0 0 0 0 0 GO:0051044 8 positive regulation of membrane protein ectodomain proteolysis 7 8 1 1 0 1 0 0 52 8 2487 0.84768 1.0 1.0 0.0 0 0 0 0 0 GO:0051056 7 regulation of small GTPase mediated signal transduction 38 40 1 1 0 1 0 0 52 40 2455 0.43537 1.0 1.0 0.0 0 0 0 0 0 GO:0051057 8 positive regulation of small GTPase mediated signal transduction 17 18 1 1 0 1 0 0 52 18 2477 0.68897 1.0 1.0 0.0 0 0 0 0 0 GO:0051091 8 positive regulation of DNA-binding transcription factor activity 80 84 2 1 0 0 0 0 52 84 2411 0.17172 1.0 0.41625 0.0 0 0 0 0 0 GO:0051092 9 positive regulation of NF-kappaB transcription factor activity 44 48 2 1 0 0 0 0 52 48 2447 0.36808 1.0 0.62471 0.0 0 0 0 0 0 GO:0051129 6 negative regulation of cellular component organization 177 187 2 2 0 2 0 0 52 187 2308 0.018186 1.0 0.030031 0.0 0 0 0 0 0 GO:0051146 6 striated muscle cell differentiation 23 24 1 1 0 0 0 0 52 24 2471 0.60815 1.0 1.0 0.0 0 0 0 0 0 GO:0051147 6 regulation of muscle cell differentiation 57 60 2 2 0 2 0 0 52 60 2435 0.28583 1.0 0.63391 0.0 0 0 0 0 0 GO:0051148 7 negative regulation of muscle cell differentiation 24 24 1 1 0 1 0 0 52 24 2471 0.60815 1.0 1.0 0.0 0 0 0 0 0 GO:0051149 7 positive regulation of muscle cell differentiation 27 30 1 1 0 1 0 0 52 30 2465 0.53665 1.0 1.0 0.0 0 0 0 0 0 GO:0051153 7 regulation of striated muscle cell differentiation 45 47 2 2 0 2 0 0 52 47 2448 0.37589 1.0 1.0 0.0 0 0 0 0 0 GO:0051154 8 negative regulation of striated muscle cell differentiation 18 18 1 1 0 1 0 0 52 18 2477 0.68897 1.0 1.0 0.0 0 0 0 0 0 GO:0051155 8 positive regulation of striated muscle cell differentiation 23 25 1 1 0 1 0 0 52 25 2470 0.59562 1.0 1.0 0.0 0 0 0 0 0 GO:0051156 5 glucose 6-phosphate metabolic process 5 5 1 1 0 1 0 0 52 5 2490 0.90193 1.0 1.0 0.0 0 0 0 0 0 GO:0051180 5 vitamin transport 12 14 1 1 0 1 0 0 52 14 2481 0.74861 1.0 1.0 0.0 0 0 0 0 0 GO:0051196 7 regulation of coenzyme metabolic process 3 3 1 1 0 1 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:0051224 6 negative regulation of protein transport 47 51 3 3 0 2 0 0 52 51 2444 0.34556 1.0 0.62518 0.0 0 0 0 0 0 GO:0051225 5 spindle assembly 18 18 1 1 0 1 0 0 52 18 2477 0.68897 1.0 1.0 0.0 0 0 0 0 0 GO:0051236 4 establishment of RNA localization 18 20 1 1 0 0 0 0 52 20 2475 0.66093 1.0 1.0 0.0 0 0 0 0 0 GO:0051251 7 positive regulation of lymphocyte activation 82 87 1 0 0 0 0 0 52 87 2408 0.16107 1.0 0.26054 0.0 0 0 0 0 0 GO:0051259 7 protein complex oligomerization 47 55 2 1 0 1 0 0 52 55 2440 0.31764 1.0 0.62784 0.0 0 0 0 0 0 GO:0051260 8 protein homooligomerization 31 35 1 0 0 0 0 0 52 35 2460 0.48342 1.0 1.0 0.0 0 0 0 0 0 GO:0051262 8 protein tetramerization 23 25 1 0 0 0 0 0 52 25 2470 0.59562 1.0 1.0 0.0 0 0 0 0 0 GO:0051276 6 chromosome organization 85 90 2 2 1 1 0 0 52 90 2405 0.15107 1.0 0.26035 0.0 0 0 0 0 0 GO:0051289 9 protein homotetramerization 12 14 1 0 0 0 0 0 52 14 2481 0.74861 1.0 1.0 0.0 0 0 0 0 0 GO:0051299 4 centrosome separation 3 3 1 1 0 1 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:0051302 5 regulation of cell division 50 51 2 2 1 1 0 0 52 51 2444 0.34556 1.0 0.62518 0.0 0 0 0 0 0 GO:0051321 3 meiotic cell cycle 9 10 2 2 0 2 0 0 52 10 2485 0.81331 1.0 1.0 0.0 0 0 0 0 0 GO:0051341 5 regulation of oxidoreductase activity 32 35 1 1 0 1 0 0 52 35 2460 0.48342 1.0 1.0 0.0 0 0 0 0 0 GO:0051345 6 positive regulation of hydrolase activity 168 180 4 4 1 2 0 0 52 180 2315 0.02125 1.0 0.048525 0.0 0 0 0 0 0 GO:0051354 6 negative regulation of oxidoreductase activity 12 12 1 1 0 1 0 0 52 12 2483 0.7803 1.0 1.0 0.0 0 0 0 0 0 GO:0051365 6 cellular response to potassium ion starvation 3 3 1 1 0 1 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:0051402 5 neuron apoptotic process 23 25 1 1 0 0 0 0 52 25 2470 0.59562 1.0 1.0 0.0 0 0 0 0 0 GO:0051403 9 stress-activated MAPK cascade 16 17 1 1 0 0 0 0 52 17 2478 0.70343 1.0 1.0 0.0 0 0 0 0 0 GO:0051445 5 regulation of meiotic cell cycle 17 19 1 1 0 1 0 0 52 19 2476 0.67481 1.0 1.0 0.0 0 0 0 0 0 GO:0051446 6 positive regulation of meiotic cell cycle 11 11 1 1 0 1 0 0 52 11 2484 0.79664 1.0 1.0 0.0 0 0 0 0 0 GO:0051492 7 regulation of stress fiber assembly 24 27 1 1 0 1 0 0 52 27 2468 0.5713 1.0 1.0 0.0 0 0 0 0 0 GO:0051495 8 positive regulation of cytoskeleton organization 51 55 2 2 0 1 0 0 52 55 2440 0.31764 1.0 0.62784 0.0 0 0 0 0 0 GO:0051496 8 positive regulation of stress fiber assembly 18 21 1 1 0 1 0 0 52 21 2474 0.64733 1.0 1.0 0.0 0 0 0 0 0 GO:0051599 4 response to hydrostatic pressure 6 6 1 1 1 0 0 0 52 6 2489 0.88348 1.0 1.0 0.0 0 0 0 0 0 GO:0051604 5 protein maturation 41 43 1 1 1 0 0 0 52 43 2452 0.40883 1.0 1.0 0.0 0 0 0 0 0 GO:0051606 3 detection of stimulus 47 49 1 1 1 0 0 0 52 49 2446 0.36042 1.0 0.62471 0.0 0 0 0 0 0 GO:0051607 5 defense response to virus 45 46 2 1 0 0 0 0 52 46 2449 0.38388 1.0 1.0 0.0 0 0 0 0 0 GO:0051640 4 organelle localization 71 74 2 2 0 2 0 0 52 74 2421 0.21247 1.0 0.40311 0.0 0 0 0 0 0 GO:0051641 3 cellular localization 308 325 4 4 0 3 0 0 52 325 2170 7.6494E-4 1.0 0.0012266 0.0 0 0 0 0 0 GO:0051642 4 centrosome localization 5 5 1 1 0 1 0 0 52 5 2490 0.90193 1.0 1.0 0.0 0 0 0 0 0 GO:0051648 5 vesicle localization 14 14 1 1 0 1 0 0 52 14 2481 0.74861 1.0 1.0 0.0 0 0 0 0 0 GO:0051649 4 establishment of localization in cell 242 254 1 1 0 1 0 0 52 254 2241 0.0040004 1.0 0.0080292 0.0 0 0 0 0 0 GO:0051650 5 establishment of vesicle localization 14 14 1 1 0 1 0 0 52 14 2481 0.74861 1.0 1.0 0.0 0 0 0 0 0 GO:0051656 4 establishment of organelle localization 52 55 1 1 0 1 0 0 52 55 2440 0.31764 1.0 0.62784 0.0 0 0 0 0 0 GO:0051701 4 interaction with host 20 21 1 1 1 0 0 0 52 21 2474 0.64733 1.0 1.0 0.0 0 0 0 0 0 GO:0051782 6 negative regulation of cell division 7 7 1 1 1 0 0 0 52 7 2488 0.8654 1.0 1.0 0.0 0 0 0 0 0 GO:0051783 7 regulation of nuclear division 47 50 1 1 0 0 0 0 52 50 2445 0.35291 1.0 0.62487 0.0 0 0 0 0 0 GO:0051785 8 positive regulation of nuclear division 23 26 1 1 0 0 0 0 52 26 2469 0.58334 1.0 1.0 0.0 0 0 0 0 0 GO:0051791 7 medium-chain fatty acid metabolic process 7 8 1 1 1 0 0 0 52 8 2487 0.84768 1.0 1.0 0.0 0 0 0 0 0 GO:0051817 4 modulation of process of other organism involved in symbiotic interaction 33 35 1 1 1 0 0 0 52 35 2460 0.48342 1.0 1.0 0.0 0 0 0 0 0 GO:0051881 5 regulation of mitochondrial membrane potential 32 32 2 2 2 0 0 0 52 32 2463 0.5147 1.0 1.0 0.0 0 0 0 0 0 GO:0051930 8 regulation of sensory perception of pain 14 14 1 1 0 1 0 0 52 14 2481 0.74861 1.0 1.0 0.0 0 0 0 0 0 GO:0051931 7 regulation of sensory perception 14 14 1 1 0 1 0 0 52 14 2481 0.74861 1.0 1.0 0.0 0 0 0 0 0 GO:0051972 6 regulation of telomerase activity 16 17 1 1 1 0 0 0 52 17 2478 0.70343 1.0 1.0 0.0 0 0 0 0 0 GO:0051973 7 positive regulation of telomerase activity 13 14 1 1 1 0 0 0 52 14 2481 0.74861 1.0 1.0 0.0 0 0 0 0 0 GO:0051983 5 regulation of chromosome segregation 25 27 1 1 0 0 0 0 52 27 2468 0.5713 1.0 1.0 0.0 0 0 0 0 0 GO:0051984 6 positive regulation of chromosome segregation 10 10 1 1 0 0 0 0 52 10 2485 0.81331 1.0 1.0 0.0 0 0 0 0 0 GO:0052646 5 alditol phosphate metabolic process 2 2 1 1 0 1 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:0052803 5 imidazole-containing compound metabolic process 2 2 1 1 1 0 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:0052805 6 imidazole-containing compound catabolic process 2 2 1 1 1 0 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:0055001 5 muscle cell development 30 30 1 1 1 0 0 0 52 30 2465 0.53665 1.0 1.0 0.0 0 0 0 0 0 GO:0055002 6 striated muscle cell development 24 24 1 1 1 0 0 0 52 24 2471 0.60815 1.0 1.0 0.0 0 0 0 0 0 GO:0055021 7 regulation of cardiac muscle tissue growth 28 29 2 2 0 2 0 0 52 29 2466 0.54796 1.0 1.0 0.0 0 0 0 0 0 GO:0055022 8 negative regulation of cardiac muscle tissue growth 11 11 1 1 0 1 0 0 52 11 2484 0.79664 1.0 1.0 0.0 0 0 0 0 0 GO:0055023 8 positive regulation of cardiac muscle tissue growth 16 17 1 1 0 1 0 0 52 17 2478 0.70343 1.0 1.0 0.0 0 0 0 0 0 GO:0055024 7 regulation of cardiac muscle tissue development 35 37 2 2 0 2 0 0 52 37 2458 0.46361 1.0 1.0 0.0 0 0 0 0 0 GO:0055025 8 positive regulation of cardiac muscle tissue development 20 22 1 1 0 1 0 0 52 22 2473 0.634 1.0 1.0 0.0 0 0 0 0 0 GO:0055026 8 negative regulation of cardiac muscle tissue development 14 14 1 1 0 1 0 0 52 14 2481 0.74861 1.0 1.0 0.0 0 0 0 0 0 GO:0055069 9 zinc ion homeostasis 2 5 1 1 0 1 0 0 52 5 2490 0.90193 1.0 1.0 0.0 0 0 0 0 0 GO:0055072 10 iron ion homeostasis 18 18 1 1 1 0 0 0 52 18 2477 0.68897 1.0 1.0 0.0 0 0 0 0 0 GO:0055076 9 transition metal ion homeostasis 23 26 2 2 1 1 0 0 52 26 2469 0.58334 1.0 1.0 0.0 0 0 0 0 0 GO:0055081 7 anion homeostasis 21 21 1 1 0 1 0 0 52 21 2474 0.64733 1.0 1.0 0.0 0 0 0 0 0 GO:0055091 7 phospholipid homeostasis 4 4 1 1 0 1 0 0 52 4 2491 0.92076 1.0 1.0 0.0 0 0 0 0 0 GO:0055094 4 response to lipoprotein particle 21 21 2 1 1 0 0 0 52 21 2474 0.64733 1.0 1.0 0.0 0 0 0 0 0 GO:0055129 9 L-proline biosynthetic process 1 1 1 1 1 0 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:0060009 5 Sertoli cell development 7 8 1 1 0 0 0 0 52 8 2487 0.84768 1.0 1.0 0.0 0 0 0 0 0 GO:0060046 6 regulation of acrosome reaction 4 4 1 1 1 0 0 0 52 4 2491 0.92076 1.0 1.0 0.0 0 0 0 0 0 GO:0060070 8 canonical Wnt signaling pathway 13 16 1 1 1 0 0 0 52 16 2479 0.71819 1.0 1.0 0.0 0 0 0 0 0 GO:0060074 6 synapse maturation 4 4 1 1 0 1 0 0 52 4 2491 0.92076 1.0 1.0 0.0 0 0 0 0 0 GO:0060078 5 regulation of postsynaptic membrane potential 20 20 1 1 0 1 0 0 52 20 2475 0.66093 1.0 1.0 0.0 0 0 0 0 0 GO:0060079 6 excitatory postsynaptic potential 16 16 1 1 0 1 0 0 52 16 2479 0.71819 1.0 1.0 0.0 0 0 0 0 0 GO:0060147 7 regulation of posttranscriptional gene silencing 13 15 1 1 0 0 0 0 52 15 2480 0.73325 1.0 1.0 0.0 0 0 0 0 0 GO:0060148 5 positive regulation of posttranscriptional gene silencing 9 10 1 1 0 0 0 0 52 10 2485 0.81331 1.0 1.0 0.0 0 0 0 0 0 GO:0060191 6 regulation of lipase activity 26 27 1 1 0 1 0 0 52 27 2468 0.5713 1.0 1.0 0.0 0 0 0 0 0 GO:0060192 7 negative regulation of lipase activity 9 10 1 1 0 1 0 0 52 10 2485 0.81331 1.0 1.0 0.0 0 0 0 0 0 GO:0060193 7 positive regulation of lipase activity 18 18 1 1 0 1 0 0 52 18 2477 0.68897 1.0 1.0 0.0 0 0 0 0 0 GO:0060211 9 regulation of nuclear-transcribed mRNA poly(A) tail shortening 3 3 1 1 0 0 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:0060213 10 positive regulation of nuclear-transcribed mRNA poly(A) tail shortening 2 2 1 1 0 0 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:0060249 5 anatomical structure homeostasis 62 66 3 2 0 1 0 0 52 66 2429 0.25176 1.0 0.64443 0.0 0 0 0 0 0 GO:0060251 6 regulation of glial cell proliferation 16 18 1 1 1 0 0 0 52 18 2477 0.68897 1.0 1.0 0.0 0 0 0 0 0 GO:0060252 7 positive regulation of glial cell proliferation 9 10 1 1 1 0 0 0 52 10 2485 0.81331 1.0 1.0 0.0 0 0 0 0 0 GO:0060260 9 regulation of transcription initiation from RNA polymerase II promoter 6 8 1 1 1 0 0 0 52 8 2487 0.84768 1.0 1.0 0.0 0 0 0 0 0 GO:0060261 10 positive regulation of transcription initiation from RNA polymerase II promoter 5 6 1 1 1 0 0 0 52 6 2489 0.88348 1.0 1.0 0.0 0 0 0 0 0 GO:0060281 6 regulation of oocyte development 12 13 1 1 0 1 0 0 52 13 2482 0.7643 1.0 1.0 0.0 0 0 0 0 0 GO:0060282 7 positive regulation of oocyte development 7 7 1 1 0 1 0 0 52 7 2488 0.8654 1.0 1.0 0.0 0 0 0 0 0 GO:0060353 5 regulation of cell adhesion molecule production 7 7 1 1 0 1 0 0 52 7 2488 0.8654 1.0 1.0 0.0 0 0 0 0 0 GO:0060354 6 negative regulation of cell adhesion molecule production 3 3 1 1 0 1 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:0060420 6 regulation of heart growth 30 31 2 2 0 2 0 0 52 31 2464 0.52556 1.0 1.0 0.0 0 0 0 0 0 GO:0060421 7 positive regulation of heart growth 16 17 1 1 0 1 0 0 52 17 2478 0.70343 1.0 1.0 0.0 0 0 0 0 0 GO:0060456 6 positive regulation of digestive system process 3 4 1 1 1 0 0 0 52 4 2491 0.92076 1.0 1.0 0.0 0 0 0 0 0 GO:0060491 6 regulation of cell projection assembly 30 36 1 1 0 0 0 0 52 36 2459 0.47341 1.0 1.0 0.0 0 0 0 0 0 GO:0060560 4 developmental growth involved in morphogenesis 27 30 1 1 0 1 0 0 52 30 2465 0.53665 1.0 1.0 0.0 0 0 0 0 0 GO:0060627 5 regulation of vesicle-mediated transport 135 149 1 1 0 1 0 0 52 149 2346 0.042112 1.0 0.071704 0.0 0 0 0 0 0 GO:0060759 5 regulation of response to cytokine stimulus 34 34 1 1 0 1 0 0 52 34 2461 0.49363 1.0 1.0 0.0 0 0 0 0 0 GO:0060761 6 negative regulation of response to cytokine stimulus 14 14 1 1 0 1 0 0 52 14 2481 0.74861 1.0 1.0 0.0 0 0 0 0 0 GO:0060964 7 regulation of gene silencing by miRNA 12 14 1 1 0 0 0 0 52 14 2481 0.74861 1.0 1.0 0.0 0 0 0 0 0 GO:0060966 6 regulation of gene silencing by RNA 13 15 1 1 0 0 0 0 52 15 2480 0.73325 1.0 1.0 0.0 0 0 0 0 0 GO:0060968 5 regulation of gene silencing 15 18 1 1 0 0 0 0 52 18 2477 0.68897 1.0 1.0 0.0 0 0 0 0 0 GO:0060992 5 response to fungicide 17 19 1 1 1 0 0 0 52 19 2476 0.67481 1.0 1.0 0.0 0 0 0 0 0 GO:0061013 7 regulation of mRNA catabolic process 16 17 2 2 1 0 0 0 52 17 2478 0.70343 1.0 1.0 0.0 0 0 0 0 0 GO:0061014 8 positive regulation of mRNA catabolic process 3 3 1 1 0 0 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:0061028 7 establishment of endothelial barrier 9 9 2 1 0 0 0 0 52 9 2486 0.83032 1.0 1.0 0.0 0 0 0 0 0 GO:0061050 6 regulation of cell growth involved in cardiac muscle cell development 14 14 2 2 0 2 0 0 52 14 2481 0.74861 1.0 1.0 0.0 0 0 0 0 0 GO:0061051 7 positive regulation of cell growth involved in cardiac muscle cell development 8 8 1 1 0 1 0 0 52 8 2487 0.84768 1.0 1.0 0.0 0 0 0 0 0 GO:0061052 7 negative regulation of cell growth involved in cardiac muscle cell development 5 5 1 1 0 1 0 0 52 5 2490 0.90193 1.0 1.0 0.0 0 0 0 0 0 GO:0061081 8 positive regulation of myeloid leukocyte cytokine production involved in immune response 8 10 1 0 0 0 0 0 52 10 2485 0.81331 1.0 1.0 0.0 0 0 0 0 0 GO:0061117 7 negative regulation of heart growth 11 11 1 1 0 1 0 0 52 11 2484 0.79664 1.0 1.0 0.0 0 0 0 0 0 GO:0061157 7 mRNA destabilization 2 2 1 1 0 0 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:0061158 8 3'-UTR-mediated mRNA destabilization 1 1 1 1 0 0 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:0061178 6 regulation of insulin secretion involved in cellular response to glucose stimulus 18 19 1 1 0 1 0 0 52 19 2476 0.67481 1.0 1.0 0.0 0 0 0 0 0 GO:0061365 8 positive regulation of triglyceride lipase activity 5 5 1 1 0 1 0 0 52 5 2490 0.90193 1.0 1.0 0.0 0 0 0 0 0 GO:0061402 9 positive regulation of transcription from RNA polymerase II promoter in response to acidic pH 2 2 1 1 0 1 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:0061515 5 myeloid cell development 17 18 2 2 1 1 0 0 52 18 2477 0.68897 1.0 1.0 0.0 0 0 0 0 0 GO:0061635 4 regulation of protein complex stability 1 4 1 1 0 1 0 0 52 4 2491 0.92076 1.0 1.0 0.0 0 0 0 0 0 GO:0061687 3 detoxification of inorganic compound 2 4 1 1 0 1 0 0 52 4 2491 0.92076 1.0 1.0 0.0 0 0 0 0 0 GO:0061726 7 mitochondrion disassembly 11 11 1 1 0 1 0 0 52 11 2484 0.79664 1.0 1.0 0.0 0 0 0 0 0 GO:0061842 3 microtubule organizing center localization 5 5 1 1 0 1 0 0 52 5 2490 0.90193 1.0 1.0 0.0 0 0 0 0 0 GO:0061912 6 selective autophagy 3 3 1 1 0 1 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:0061919 3 process utilizing autophagic mechanism 36 40 1 1 0 1 0 0 52 40 2455 0.43537 1.0 1.0 0.0 0 0 0 0 0 GO:0062013 6 positive regulation of small molecule metabolic process 62 68 7 7 1 6 0 0 52 68 2427 0.24132 1.0 0.40137 0.0 0 0 0 0 0 GO:0062033 7 positive regulation of mitotic sister chromatid segregation 5 5 1 1 0 0 0 0 52 5 2490 0.90193 1.0 1.0 0.0 0 0 0 0 0 GO:0065005 7 protein-lipid complex assembly 7 7 1 1 0 1 0 0 52 7 2488 0.8654 1.0 1.0 0.0 0 0 0 0 0 GO:0070169 6 positive regulation of biomineral tissue development 13 14 1 1 0 0 0 0 52 14 2481 0.74861 1.0 1.0 0.0 0 0 0 0 0 GO:0070227 7 lymphocyte apoptotic process 11 13 1 1 1 0 0 0 52 13 2482 0.7643 1.0 1.0 0.0 0 0 0 0 0 GO:0070228 9 regulation of lymphocyte apoptotic process 20 22 1 1 1 0 0 0 52 22 2473 0.634 1.0 1.0 0.0 0 0 0 0 0 GO:0070230 10 positive regulation of lymphocyte apoptotic process 7 7 1 1 1 0 0 0 52 7 2488 0.8654 1.0 1.0 0.0 0 0 0 0 0 GO:0070265 4 necrotic cell death 9 9 1 1 0 1 0 0 52 9 2486 0.83032 1.0 1.0 0.0 0 0 0 0 0 GO:0070266 6 necroptotic process 8 8 1 1 0 1 0 0 52 8 2487 0.84768 1.0 1.0 0.0 0 0 0 0 0 GO:0070302 6 regulation of stress-activated protein kinase signaling cascade 57 61 1 1 1 0 0 0 52 61 2434 0.27985 1.0 0.63545 0.0 0 0 0 0 0 GO:0070303 7 negative regulation of stress-activated protein kinase signaling cascade 7 7 1 1 1 0 0 0 52 7 2488 0.8654 1.0 1.0 0.0 0 0 0 0 0 GO:0070371 9 ERK1 and ERK2 cascade 13 14 2 2 1 1 0 0 52 14 2481 0.74861 1.0 1.0 0.0 0 0 0 0 0 GO:0070372 8 regulation of ERK1 and ERK2 cascade 108 115 2 2 1 0 0 0 52 115 2380 0.088259 1.0 0.17097 0.0 0 0 0 0 0 GO:0070374 9 positive regulation of ERK1 and ERK2 cascade 75 80 2 2 1 0 0 0 52 80 2415 0.18701 1.0 0.40963 0.0 0 0 0 0 0 GO:0070508 9 cholesterol import 4 4 1 1 0 1 0 0 52 4 2491 0.92076 1.0 1.0 0.0 0 0 0 0 0 GO:0070541 6 response to platinum ion 3 3 1 1 1 0 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:0070555 6 response to interleukin-1 63 66 3 3 1 1 0 0 52 66 2429 0.25176 1.0 0.64443 0.0 0 0 0 0 0 GO:0070587 7 regulation of cell-cell adhesion involved in gastrulation 4 4 1 1 0 1 0 0 52 4 2491 0.92076 1.0 1.0 0.0 0 0 0 0 0 GO:0070633 5 transepithelial transport 7 7 1 1 0 1 0 0 52 7 2488 0.8654 1.0 1.0 0.0 0 0 0 0 0 GO:0070663 6 regulation of leukocyte proliferation 83 88 1 0 0 0 0 0 52 88 2407 0.15766 1.0 0.26036 0.0 0 0 0 0 0 GO:0070665 7 positive regulation of leukocyte proliferation 54 58 1 0 0 0 0 0 52 58 2437 0.29816 1.0 0.63115 0.0 0 0 0 0 0 GO:0070670 6 response to interleukin-4 17 17 1 0 0 0 0 0 52 17 2478 0.70343 1.0 1.0 0.0 0 0 0 0 0 GO:0070727 4 cellular macromolecule localization 185 196 3 3 0 2 0 0 52 196 2299 0.014877 1.0 0.030709 0.0 0 0 0 0 0 GO:0070741 6 response to interleukin-6 14 14 2 2 0 1 0 0 52 14 2481 0.74861 1.0 1.0 0.0 0 0 0 0 0 GO:0070849 4 response to epidermal growth factor 25 26 2 2 1 0 0 0 52 26 2469 0.58334 1.0 1.0 0.0 0 0 0 0 0 GO:0070861 8 regulation of protein exit from endoplasmic reticulum 7 7 1 1 0 0 0 0 52 7 2488 0.8654 1.0 1.0 0.0 0 0 0 0 0 GO:0070862 8 negative regulation of protein exit from endoplasmic reticulum 3 3 1 1 0 0 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:0070925 6 organelle assembly 79 80 2 2 1 1 0 0 52 80 2415 0.18701 1.0 0.40963 0.0 0 0 0 0 0 GO:0070935 8 3'-UTR-mediated mRNA stabilization 5 5 1 1 0 0 0 0 52 5 2490 0.90193 1.0 1.0 0.0 0 0 0 0 0 GO:0070989 4 oxidative demethylation 3 4 1 1 0 1 0 0 52 4 2491 0.92076 1.0 1.0 0.0 0 0 0 0 0 GO:0070997 4 neuron death 26 28 1 1 0 0 0 0 52 28 2467 0.55952 1.0 1.0 0.0 0 0 0 0 0 GO:0071103 7 DNA conformation change 30 32 1 1 0 1 0 0 52 32 2463 0.5147 1.0 1.0 0.0 0 0 0 0 0 GO:0071230 6 cellular response to amino acid stimulus 36 39 1 1 0 0 0 0 52 39 2456 0.44459 1.0 1.0 0.0 0 0 0 0 0 GO:0071233 7 cellular response to leucine 2 2 1 1 0 0 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:0071243 5 cellular response to arsenic-containing substance 6 6 1 1 1 0 0 0 52 6 2489 0.88348 1.0 1.0 0.0 0 0 0 0 0 GO:0071247 6 cellular response to chromate 2 2 1 1 0 1 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:0071265 8 L-methionine biosynthetic process 4 4 1 1 0 1 0 0 52 4 2491 0.92076 1.0 1.0 0.0 0 0 0 0 0 GO:0071267 7 L-methionine salvage 4 4 1 1 0 1 0 0 52 4 2491 0.92076 1.0 1.0 0.0 0 0 0 0 0 GO:0071276 7 cellular response to cadmium ion 18 20 2 2 0 2 0 0 52 20 2475 0.66093 1.0 1.0 0.0 0 0 0 0 0 GO:0071277 7 cellular response to calcium ion 24 25 1 1 0 1 0 0 52 25 2470 0.59562 1.0 1.0 0.0 0 0 0 0 0 GO:0071281 7 cellular response to iron ion 8 9 1 1 0 1 0 0 52 9 2486 0.83032 1.0 1.0 0.0 0 0 0 0 0 GO:0071282 8 cellular response to iron(II) ion 2 2 1 1 0 1 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:0071294 7 cellular response to zinc ion 4 7 1 1 0 1 0 0 52 7 2488 0.8654 1.0 1.0 0.0 0 0 0 0 0 GO:0071322 6 cellular response to carbohydrate stimulus 59 62 6 5 2 2 0 0 52 62 2433 0.274 1.0 0.63707 0.0 0 0 0 0 0 GO:0071326 7 cellular response to monosaccharide stimulus 53 56 5 4 1 2 0 0 52 56 2439 0.31101 1.0 0.62883 0.0 0 0 0 0 0 GO:0071331 8 cellular response to hexose stimulus 52 55 5 4 1 2 0 0 52 55 2440 0.31764 1.0 0.62784 0.0 0 0 0 0 0 GO:0071332 9 cellular response to fructose stimulus 4 4 2 1 0 1 0 0 52 4 2491 0.92076 1.0 1.0 0.0 0 0 0 0 0 GO:0071333 8 cellular response to glucose stimulus 51 54 4 4 1 2 0 0 52 54 2441 0.32441 1.0 0.62697 0.0 0 0 0 0 0 GO:0071346 7 cellular response to interferon-gamma 36 39 3 3 2 0 0 0 52 39 2456 0.44459 1.0 1.0 0.0 0 0 0 0 0 GO:0071347 7 cellular response to interleukin-1 47 50 3 3 1 1 0 0 52 50 2445 0.35291 1.0 0.62487 0.0 0 0 0 0 0 GO:0071353 7 cellular response to interleukin-4 15 15 1 0 0 0 0 0 52 15 2480 0.73325 1.0 1.0 0.0 0 0 0 0 0 GO:0071354 7 cellular response to interleukin-6 12 12 1 1 0 0 0 0 52 12 2483 0.7803 1.0 1.0 0.0 0 0 0 0 0 GO:0071364 6 cellular response to epidermal growth factor stimulus 19 20 2 2 1 0 0 0 52 20 2475 0.66093 1.0 1.0 0.0 0 0 0 0 0 GO:0071377 7 cellular response to glucagon stimulus 7 7 2 2 1 1 0 0 52 7 2488 0.8654 1.0 1.0 0.0 0 0 0 0 0 GO:0071379 6 cellular response to prostaglandin stimulus 12 12 1 0 0 0 0 0 52 12 2483 0.7803 1.0 1.0 0.0 0 0 0 0 0 GO:0071380 7 cellular response to prostaglandin E stimulus 11 11 1 0 0 0 0 0 52 11 2484 0.79664 1.0 1.0 0.0 0 0 0 0 0 GO:0071386 7 cellular response to corticosterone stimulus 2 2 1 1 0 1 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:0071389 8 cellular response to mineralocorticoid stimulus 7 8 1 1 0 1 0 0 52 8 2487 0.84768 1.0 1.0 0.0 0 0 0 0 0 GO:0071391 4 cellular response to estrogen stimulus 5 5 1 1 1 0 0 0 52 5 2490 0.90193 1.0 1.0 0.0 0 0 0 0 0 GO:0071401 6 cellular response to triglyceride 1 1 1 1 0 1 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:0071402 4 cellular response to lipoprotein particle stimulus 23 23 2 1 1 0 0 0 52 23 2472 0.62094 1.0 1.0 0.0 0 0 0 0 0 GO:0071404 5 cellular response to low-density lipoprotein particle stimulus 17 17 1 1 1 0 0 0 52 17 2478 0.70343 1.0 1.0 0.0 0 0 0 0 0 GO:0071409 6 cellular response to cycloheximide 3 3 1 1 1 0 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:0071459 8 protein localization to chromosome, centromeric region 8 10 1 1 0 0 0 0 52 10 2485 0.81331 1.0 1.0 0.0 0 0 0 0 0 GO:0071462 5 cellular response to water stimulus 4 4 1 1 1 0 0 0 52 4 2491 0.92076 1.0 1.0 0.0 0 0 0 0 0 GO:0071464 5 cellular response to hydrostatic pressure 3 3 1 1 1 0 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:0071467 5 cellular response to pH 6 7 2 2 0 2 0 0 52 7 2488 0.8654 1.0 1.0 0.0 0 0 0 0 0 GO:0071468 6 cellular response to acidic pH 2 3 1 1 0 1 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:0071482 6 cellular response to light stimulus 37 39 1 1 1 0 0 0 52 39 2456 0.44459 1.0 1.0 0.0 0 0 0 0 0 GO:0071501 5 cellular response to sterol depletion 2 2 1 1 0 1 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:0071539 10 protein localization to centrosome 4 4 1 1 0 1 0 0 52 4 2491 0.92076 1.0 1.0 0.0 0 0 0 0 0 GO:0071548 6 response to dexamethasone 48 52 3 3 0 2 0 0 52 52 2443 0.33837 1.0 0.62564 0.0 0 0 0 0 0 GO:0071549 7 cellular response to dexamethasone stimulus 35 36 2 2 0 1 0 0 52 36 2459 0.47341 1.0 1.0 0.0 0 0 0 0 0 GO:0071615 4 oxidative deethylation 1 1 1 1 0 1 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:0071616 7 acyl-CoA biosynthetic process 11 13 1 0 0 0 0 0 52 13 2482 0.7643 1.0 1.0 0.0 0 0 0 0 0 GO:0071692 5 protein localization to extracellular region 27 29 1 1 0 0 0 0 52 29 2466 0.54796 1.0 1.0 0.0 0 0 0 0 0 GO:0071824 6 protein-DNA complex subunit organization 34 41 1 1 1 0 0 0 52 41 2454 0.42634 1.0 1.0 0.0 0 0 0 0 0 GO:0071868 6 cellular response to monoamine stimulus 14 14 1 0 0 0 0 0 52 14 2481 0.74861 1.0 1.0 0.0 0 0 0 0 0 GO:0071870 6 cellular response to catecholamine stimulus 14 14 1 0 0 0 0 0 52 14 2481 0.74861 1.0 1.0 0.0 0 0 0 0 0 GO:0071871 6 response to epinephrine 8 9 1 0 0 0 0 0 52 9 2486 0.83032 1.0 1.0 0.0 0 0 0 0 0 GO:0071872 7 cellular response to epinephrine stimulus 5 5 1 0 0 0 0 0 52 5 2490 0.90193 1.0 1.0 0.0 0 0 0 0 0 GO:0071887 6 leukocyte apoptotic process 16 18 1 1 1 0 0 0 52 18 2477 0.68897 1.0 1.0 0.0 0 0 0 0 0 GO:0071897 6 DNA biosynthetic process 14 18 1 1 0 1 0 0 52 18 2477 0.68897 1.0 1.0 0.0 0 0 0 0 0 GO:0071901 9 negative regulation of protein serine/threonine kinase activity 40 43 1 1 0 0 0 0 52 43 2452 0.40883 1.0 1.0 0.0 0 0 0 0 0 GO:0071922 6 regulation of cohesin loading 1 2 1 1 0 0 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:0071930 8 negative regulation of transcription involved in G1/S transition of mitotic cell cycle 3 3 1 1 0 0 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:0071966 7 fungal-type cell wall polysaccharide metabolic process 1 1 1 1 1 0 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:0072329 7 monocarboxylic acid catabolic process 43 48 4 4 0 2 0 0 52 48 2447 0.36808 1.0 0.62471 0.0 0 0 0 0 0 GO:0072331 6 signal transduction by p53 class mediator 28 29 2 2 0 1 0 0 52 29 2466 0.54796 1.0 1.0 0.0 0 0 0 0 0 GO:0072384 5 organelle transport along microtubule 10 11 1 1 0 1 0 0 52 11 2484 0.79664 1.0 1.0 0.0 0 0 0 0 0 GO:0072522 6 purine-containing compound biosynthetic process 35 40 2 0 0 0 0 0 52 40 2455 0.43537 1.0 1.0 0.0 0 0 0 0 0 GO:0072524 5 pyridine-containing compound metabolic process 8 8 1 1 0 1 0 0 52 8 2487 0.84768 1.0 1.0 0.0 0 0 0 0 0 GO:0072525 6 pyridine-containing compound biosynthetic process 7 7 1 1 0 1 0 0 52 7 2488 0.8654 1.0 1.0 0.0 0 0 0 0 0 GO:0072577 7 endothelial cell apoptotic process 1 2 1 1 1 0 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:0072608 7 interleukin-10 secretion 1 1 1 1 0 0 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:0072643 7 interferon-gamma secretion 2 2 1 1 0 0 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:0072676 6 lymphocyte migration 27 28 1 1 0 0 0 0 52 28 2467 0.55952 1.0 1.0 0.0 0 0 0 0 0 GO:0072678 7 T cell migration 13 14 1 1 0 0 0 0 52 14 2481 0.74861 1.0 1.0 0.0 0 0 0 0 0 GO:0072683 7 T cell extravasation 4 4 1 1 0 0 0 0 52 4 2491 0.92076 1.0 1.0 0.0 0 0 0 0 0 GO:0072698 8 protein localization to microtubule cytoskeleton 7 7 1 1 0 1 0 0 52 7 2488 0.8654 1.0 1.0 0.0 0 0 0 0 0 GO:0080154 5 regulation of fertilization 4 4 1 1 1 0 0 0 52 4 2491 0.92076 1.0 1.0 0.0 0 0 0 0 0 GO:0090036 7 regulation of protein kinase C signaling 3 3 1 1 0 1 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:0090066 4 regulation of anatomical structure size 103 112 2 2 0 1 0 0 52 112 2383 0.094166 1.0 0.16982 0.0 0 0 0 0 0 GO:0090080 8 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway 1 1 1 1 1 0 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:0090095 7 regulation of metanephric cap mesenchymal cell proliferation 1 1 1 1 1 0 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:0090096 7 positive regulation of metanephric cap mesenchymal cell proliferation 1 1 1 1 1 0 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:0090186 5 regulation of pancreatic juice secretion 3 3 1 1 1 0 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:0090187 6 positive regulation of pancreatic juice secretion 2 2 1 1 1 0 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:0090205 7 positive regulation of cholesterol metabolic process 7 7 2 2 0 2 0 0 52 7 2488 0.8654 1.0 1.0 0.0 0 0 0 0 0 GO:0090207 6 regulation of triglyceride metabolic process 24 26 4 4 1 3 0 0 52 26 2469 0.58334 1.0 1.0 0.0 0 0 0 0 0 GO:0090208 7 positive regulation of triglyceride metabolic process 15 17 4 4 1 3 0 0 52 17 2478 0.70343 1.0 1.0 0.0 0 0 0 0 0 GO:0090209 7 negative regulation of triglyceride metabolic process 8 8 1 1 0 1 0 0 52 8 2487 0.84768 1.0 1.0 0.0 0 0 0 0 0 GO:0090257 6 regulation of muscle system process 64 65 3 3 0 3 0 0 52 65 2430 0.25715 1.0 0.64247 0.0 0 0 0 0 0 GO:0090276 6 regulation of peptide hormone secretion 58 63 3 3 1 2 0 0 52 63 2432 0.26826 1.0 0.63879 0.0 0 0 0 0 0 GO:0090277 7 positive regulation of peptide hormone secretion 36 38 2 2 1 1 0 0 52 38 2457 0.454 1.0 1.0 0.0 0 0 0 0 0 GO:0090278 7 negative regulation of peptide hormone secretion 13 14 1 1 0 1 0 0 52 14 2481 0.74861 1.0 1.0 0.0 0 0 0 0 0 GO:0090279 9 regulation of calcium ion import 17 21 1 1 1 0 0 0 52 21 2474 0.64733 1.0 1.0 0.0 0 0 0 0 0 GO:0090281 8 negative regulation of calcium ion import 4 5 1 1 1 0 0 0 52 5 2490 0.90193 1.0 1.0 0.0 0 0 0 0 0 GO:0090305 6 nucleic acid phosphodiester bond hydrolysis 28 32 1 1 1 0 0 0 52 32 2463 0.5147 1.0 1.0 0.0 0 0 0 0 0 GO:0090306 6 spindle assembly involved in meiosis 3 3 1 1 0 1 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:0090311 8 regulation of protein deacetylation 18 19 2 2 0 1 0 0 52 19 2476 0.67481 1.0 1.0 0.0 0 0 0 0 0 GO:0090312 9 positive regulation of protein deacetylation 10 11 2 2 0 1 0 0 52 11 2484 0.79664 1.0 1.0 0.0 0 0 0 0 0 GO:0090317 7 negative regulation of intracellular protein transport 13 15 1 1 0 0 0 0 52 15 2480 0.73325 1.0 1.0 0.0 0 0 0 0 0 GO:0090407 5 organophosphate biosynthetic process 89 97 6 4 0 4 0 0 52 97 2398 0.13003 1.0 0.26383 0.0 0 0 0 0 0 GO:0090501 7 RNA phosphodiester bond hydrolysis 18 22 1 1 1 0 0 0 52 22 2473 0.634 1.0 1.0 0.0 0 0 0 0 0 GO:0090503 8 RNA phosphodiester bond hydrolysis, exonucleolytic 7 7 1 1 1 0 0 0 52 7 2488 0.8654 1.0 1.0 0.0 0 0 0 0 0 GO:0090557 8 establishment of endothelial intestinal barrier 6 6 2 1 0 0 0 0 52 6 2489 0.88348 1.0 1.0 0.0 0 0 0 0 0 GO:0097009 5 energy homeostasis 9 10 1 1 0 1 0 0 52 10 2485 0.81331 1.0 1.0 0.0 0 0 0 0 0 GO:0097011 7 cellular response to granulocyte macrophage colony-stimulating factor stimulus 5 5 1 1 0 0 0 0 52 5 2490 0.90193 1.0 1.0 0.0 0 0 0 0 0 GO:0097012 6 response to granulocyte macrophage colony-stimulating factor 5 5 1 1 0 0 0 0 52 5 2490 0.90193 1.0 1.0 0.0 0 0 0 0 0 GO:0097150 4 neuronal stem cell population maintenance 9 9 1 1 0 1 0 0 52 9 2486 0.83032 1.0 1.0 0.0 0 0 0 0 0 GO:0097164 4 ammonium ion metabolic process 9 10 2 2 1 1 0 0 52 10 2485 0.81331 1.0 1.0 0.0 0 0 0 0 0 GO:0097192 6 extrinsic apoptotic signaling pathway in absence of ligand 22 22 1 1 0 1 0 0 52 22 2473 0.634 1.0 1.0 0.0 0 0 0 0 0 GO:0097267 7 omega-hydroxylase P450 pathway 2 2 1 1 1 0 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:0097284 7 hepatocyte apoptotic process 10 10 1 1 0 0 0 0 52 10 2485 0.81331 1.0 1.0 0.0 0 0 0 0 0 GO:0097300 5 programmed necrotic cell death 9 9 1 1 0 1 0 0 52 9 2486 0.83032 1.0 1.0 0.0 0 0 0 0 0 GO:0097368 6 establishment of Sertoli cell barrier 3 4 1 1 0 0 0 0 52 4 2491 0.92076 1.0 1.0 0.0 0 0 0 0 0 GO:0097384 5 cellular lipid biosynthetic process 2 2 1 0 0 0 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:0097411 5 hypoxia-inducible factor-1alpha signaling pathway 3 3 1 1 0 1 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:0097479 6 synaptic vesicle localization 8 8 1 1 0 1 0 0 52 8 2487 0.84768 1.0 1.0 0.0 0 0 0 0 0 GO:0097746 6 regulation of blood vessel diameter 54 57 2 2 0 1 0 0 52 57 2438 0.30452 1.0 0.62993 0.0 0 0 0 0 0 GO:0097755 7 positive regulation of blood vessel diameter 27 28 1 1 0 1 0 0 52 28 2467 0.55952 1.0 1.0 0.0 0 0 0 0 0 GO:0097756 7 negative regulation of blood vessel diameter 12 13 1 1 0 1 0 0 52 13 2482 0.7643 1.0 1.0 0.0 0 0 0 0 0 GO:0098609 4 cell-cell adhesion 84 86 1 1 0 0 0 0 52 86 2409 0.16455 1.0 0.42017 0.0 0 0 0 0 0 GO:0098657 5 import into cell 30 32 1 0 0 0 0 0 52 32 2463 0.5147 1.0 1.0 0.0 0 0 0 0 0 GO:0098704 5 carbohydrate import across plasma membrane 2 3 1 0 0 0 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:0098727 3 maintenance of cell number 28 29 2 1 0 1 0 0 52 29 2466 0.54796 1.0 1.0 0.0 0 0 0 0 0 GO:0098739 5 import across plasma membrane 17 19 1 0 0 0 0 0 52 19 2476 0.67481 1.0 1.0 0.0 0 0 0 0 0 GO:0098780 5 response to mitochondrial depolarisation 3 4 1 1 0 1 0 0 52 4 2491 0.92076 1.0 1.0 0.0 0 0 0 0 0 GO:0098801 6 regulation of renal system process 11 12 1 1 0 1 0 0 52 12 2483 0.7803 1.0 1.0 0.0 0 0 0 0 0 GO:0098916 6 anterograde trans-synaptic signaling 38 38 1 1 1 0 0 0 52 38 2457 0.454 1.0 1.0 0.0 0 0 0 0 0 GO:0098930 8 axonal transport 10 11 1 1 0 1 0 0 52 11 2484 0.79664 1.0 1.0 0.0 0 0 0 0 0 GO:0099111 5 microtubule-based transport 18 21 1 1 0 1 0 0 52 21 2474 0.64733 1.0 1.0 0.0 0 0 0 0 0 GO:0099514 6 synaptic vesicle cytoskeletal transport 2 2 1 1 0 1 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:0099517 7 synaptic vesicle transport along microtubule 2 2 1 1 0 1 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:0099518 6 vesicle cytoskeletal trafficking 7 7 1 1 0 1 0 0 52 7 2488 0.8654 1.0 1.0 0.0 0 0 0 0 0 GO:0099536 4 synaptic signaling 45 45 1 1 1 0 0 0 52 45 2450 0.39202 1.0 1.0 0.0 0 0 0 0 0 GO:0099537 5 trans-synaptic signaling 45 45 1 1 1 0 0 0 52 45 2450 0.39202 1.0 1.0 0.0 0 0 0 0 0 GO:0106118 8 regulation of sterol biosynthetic process 10 10 3 3 0 3 0 0 52 10 2485 0.81331 1.0 1.0 0.0 0 0 0 0 0 GO:0106120 9 positive regulation of sterol biosynthetic process 6 6 2 2 0 2 0 0 52 6 2489 0.88348 1.0 1.0 0.0 0 0 0 0 0 GO:0110020 7 regulation of actomyosin structure organization 31 34 1 1 0 1 0 0 52 34 2461 0.49363 1.0 1.0 0.0 0 0 0 0 0 GO:0110053 7 regulation of actin filament organization 56 59 2 2 0 1 0 0 52 59 2436 0.29193 1.0 0.63248 0.0 0 0 0 0 0 GO:0110110 6 positive regulation of animal organ morphogenesis 33 35 1 1 1 0 0 0 52 35 2460 0.48342 1.0 1.0 0.0 0 0 0 0 0 GO:0110151 5 positive regulation of biomineralization 13 14 1 1 0 0 0 0 52 14 2481 0.74861 1.0 1.0 0.0 0 0 0 0 0 GO:0110154 7 RNA decapping 3 3 1 1 1 0 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:0110156 8 methylguanosine-cap decapping 3 3 1 1 1 0 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:0120032 7 regulation of plasma membrane bounded cell projection assembly 29 35 1 1 0 0 0 0 52 35 2460 0.48342 1.0 1.0 0.0 0 0 0 0 0 GO:0120178 6 steroid hormone biosynthetic process 11 13 1 1 0 1 0 0 52 13 2482 0.7643 1.0 1.0 0.0 0 0 0 0 0 GO:0140052 5 cellular response to oxidised low-density lipoprotein particle stimulus 5 5 1 0 0 0 0 0 52 5 2490 0.90193 1.0 1.0 0.0 0 0 0 0 0 GO:0140271 6 hexose import across plasma membrane 2 3 1 0 0 0 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:1900003 8 regulation of serine-type endopeptidase activity 2 2 1 1 1 0 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:1900004 9 negative regulation of serine-type endopeptidase activity 2 2 1 1 1 0 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:1900006 9 positive regulation of dendrite development 24 27 1 1 0 1 0 0 52 27 2468 0.5713 1.0 1.0 0.0 0 0 0 0 0 GO:1900015 6 regulation of cytokine production involved in inflammatory response 11 13 1 0 0 0 0 0 52 13 2482 0.7643 1.0 1.0 0.0 0 0 0 0 0 GO:1900017 7 positive regulation of cytokine production involved in inflammatory response 6 7 1 0 0 0 0 0 52 7 2488 0.8654 1.0 1.0 0.0 0 0 0 0 0 GO:1900024 7 regulation of substrate adhesion-dependent cell spreading 16 18 1 1 0 1 0 0 52 18 2477 0.68897 1.0 1.0 0.0 0 0 0 0 0 GO:1900026 8 positive regulation of substrate adhesion-dependent cell spreading 12 14 1 1 0 1 0 0 52 14 2481 0.74861 1.0 1.0 0.0 0 0 0 0 0 GO:1900027 8 regulation of ruffle assembly 5 7 1 1 0 0 0 0 52 7 2488 0.8654 1.0 1.0 0.0 0 0 0 0 0 GO:1900151 8 regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 3 3 1 1 0 0 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:1900153 9 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 2 2 1 1 0 0 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:1900180 7 regulation of protein localization to nucleus 47 51 1 1 0 0 0 0 52 51 2444 0.34556 1.0 0.62518 0.0 0 0 0 0 0 GO:1900182 7 positive regulation of protein localization to nucleus 32 34 1 1 0 0 0 0 52 34 2461 0.49363 1.0 1.0 0.0 0 0 0 0 0 GO:1900193 7 regulation of oocyte maturation 11 12 1 1 0 1 0 0 52 12 2483 0.7803 1.0 1.0 0.0 0 0 0 0 0 GO:1900195 8 positive regulation of oocyte maturation 7 7 1 1 0 1 0 0 52 7 2488 0.8654 1.0 1.0 0.0 0 0 0 0 0 GO:1900271 6 regulation of long-term synaptic potentiation 13 15 1 1 0 1 0 0 52 15 2480 0.73325 1.0 1.0 0.0 0 0 0 0 0 GO:1900273 6 positive regulation of long-term synaptic potentiation 7 8 1 1 0 1 0 0 52 8 2487 0.84768 1.0 1.0 0.0 0 0 0 0 0 GO:1900371 8 regulation of purine nucleotide biosynthetic process 11 12 2 2 1 1 0 0 52 12 2483 0.7803 1.0 1.0 0.0 0 0 0 0 0 GO:1900373 9 positive regulation of purine nucleotide biosynthetic process 7 8 1 1 1 0 0 0 52 8 2487 0.84768 1.0 1.0 0.0 0 0 0 0 0 GO:1900409 6 positive regulation of cellular response to oxidative stress 8 11 1 1 0 1 0 0 52 11 2484 0.79664 1.0 1.0 0.0 0 0 0 0 0 GO:1900542 7 regulation of purine nucleotide metabolic process 30 32 3 3 1 2 0 0 52 32 2463 0.5147 1.0 1.0 0.0 0 0 0 0 0 GO:1900544 8 positive regulation of purine nucleotide metabolic process 17 19 2 2 1 1 0 0 52 19 2476 0.67481 1.0 1.0 0.0 0 0 0 0 0 GO:1901033 7 positive regulation of response to reactive oxygen species 4 7 1 1 0 1 0 0 52 7 2488 0.8654 1.0 1.0 0.0 0 0 0 0 0 GO:1901136 5 carbohydrate derivative catabolic process 18 22 1 1 0 1 0 0 52 22 2473 0.634 1.0 1.0 0.0 0 0 0 0 0 GO:1901215 7 negative regulation of neuron death 102 106 2 2 1 1 0 0 52 106 2389 0.10717 1.0 0.27551 0.0 0 0 0 0 0 GO:1901293 6 nucleoside phosphate biosynthetic process 50 55 3 1 0 1 0 0 52 55 2440 0.31764 1.0 0.62784 0.0 0 0 0 0 0 GO:1901298 7 regulation of hydrogen peroxide-mediated programmed cell death 6 8 1 1 0 1 0 0 52 8 2487 0.84768 1.0 1.0 0.0 0 0 0 0 0 GO:1901300 8 positive regulation of hydrogen peroxide-mediated programmed cell death 1 3 1 1 0 1 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:1901385 8 regulation of voltage-gated calcium channel activity 4 4 1 1 1 0 0 0 52 4 2491 0.92076 1.0 1.0 0.0 0 0 0 0 0 GO:1901387 8 positive regulation of voltage-gated calcium channel activity 1 1 1 1 1 0 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:1901503 5 ether biosynthetic process 1 1 1 0 0 0 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:1901657 5 glycosyl compound metabolic process 17 22 2 2 0 2 0 0 52 22 2473 0.634 1.0 1.0 0.0 0 0 0 0 0 GO:1901661 5 quinone metabolic process 5 6 1 1 0 1 0 0 52 6 2489 0.88348 1.0 1.0 0.0 0 0 0 0 0 GO:1901787 8 benzoyl-CoA metabolic process 1 1 1 1 0 1 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:1901799 10 negative regulation of proteasomal protein catabolic process 10 10 1 1 0 0 0 0 52 10 2485 0.81331 1.0 1.0 0.0 0 0 0 0 0 GO:1901834 8 regulation of deadenylation-independent decapping of nuclear-transcribed mRNA 1 1 1 1 0 0 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:1901835 9 positive regulation of deadenylation-independent decapping of nuclear-transcribed mRNA 1 1 1 1 0 0 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:1901857 7 positive regulation of cellular respiration 8 9 1 1 1 0 0 0 52 9 2486 0.83032 1.0 1.0 0.0 0 0 0 0 0 GO:1901861 5 regulation of muscle tissue development 56 58 3 3 0 3 0 0 52 58 2437 0.29816 1.0 0.63115 0.0 0 0 0 0 0 GO:1901862 6 negative regulation of muscle tissue development 21 21 1 1 0 1 0 0 52 21 2474 0.64733 1.0 1.0 0.0 0 0 0 0 0 GO:1901863 6 positive regulation of muscle tissue development 31 33 1 1 0 1 0 0 52 33 2462 0.50406 1.0 1.0 0.0 0 0 0 0 0 GO:1901970 8 positive regulation of mitotic sister chromatid separation 3 3 1 1 0 0 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:1901976 6 regulation of cell cycle checkpoint 6 6 1 0 0 0 0 0 52 6 2489 0.88348 1.0 1.0 0.0 0 0 0 0 0 GO:1902010 9 negative regulation of translation in response to endoplasmic reticulum stress 1 1 1 1 0 0 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:1902031 5 regulation of NADP metabolic process 5 5 1 1 0 1 0 0 52 5 2490 0.90193 1.0 1.0 0.0 0 0 0 0 0 GO:1902041 8 regulation of extrinsic apoptotic signaling pathway via death domain receptors 21 23 1 1 0 0 0 0 52 23 2472 0.62094 1.0 1.0 0.0 0 0 0 0 0 GO:1902042 9 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors 18 19 1 1 0 0 0 0 52 19 2476 0.67481 1.0 1.0 0.0 0 0 0 0 0 GO:1902099 7 regulation of metaphase/anaphase transition of cell cycle 15 15 1 1 0 0 0 0 52 15 2480 0.73325 1.0 1.0 0.0 0 0 0 0 0 GO:1902101 8 positive regulation of metaphase/anaphase transition of cell cycle 3 3 1 1 0 0 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:1902172 9 regulation of keratinocyte apoptotic process 1 1 1 1 0 0 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:1902275 8 regulation of chromatin organization 37 37 2 2 0 1 0 0 52 37 2458 0.46361 1.0 1.0 0.0 0 0 0 0 0 GO:1902369 8 negative regulation of RNA catabolic process 11 11 2 2 1 0 0 0 52 11 2484 0.79664 1.0 1.0 0.0 0 0 0 0 0 GO:1902373 8 negative regulation of mRNA catabolic process 11 11 2 2 1 0 0 0 52 11 2484 0.79664 1.0 1.0 0.0 0 0 0 0 0 GO:1902514 9 regulation of calcium ion transmembrane transport via high voltage-gated calcium channel 3 3 1 1 0 1 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:1902571 7 regulation of serine-type peptidase activity 2 2 1 1 1 0 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:1902572 8 negative regulation of serine-type peptidase activity 2 2 1 1 1 0 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:1902644 5 tertiary alcohol metabolic process 2 3 1 1 0 1 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:1902652 5 secondary alcohol metabolic process 53 54 7 7 0 7 0 0 52 54 2441 0.32441 1.0 0.62697 0.0 0 0 0 0 0 GO:1902653 6 secondary alcohol biosynthetic process 22 22 4 4 0 4 0 0 52 22 2473 0.634 1.0 1.0 0.0 0 0 0 0 0 GO:1902850 6 microtubule cytoskeleton organization involved in mitosis 28 28 1 1 0 1 0 0 52 28 2467 0.55952 1.0 1.0 0.0 0 0 0 0 0 GO:1902884 6 positive regulation of response to oxidative stress 9 12 1 1 0 1 0 0 52 12 2483 0.7803 1.0 1.0 0.0 0 0 0 0 0 GO:1902903 6 regulation of supramolecular fiber organization 89 94 3 3 0 1 0 0 52 94 2401 0.13867 1.0 0.26169 0.0 0 0 0 0 0 GO:1902905 7 positive regulation of supramolecular fiber organization 50 53 3 3 0 1 0 0 52 53 2442 0.33131 1.0 0.62624 0.0 0 0 0 0 0 GO:1902930 6 regulation of alcohol biosynthetic process 20 21 3 3 0 3 0 0 52 21 2474 0.64733 1.0 1.0 0.0 0 0 0 0 0 GO:1902932 7 positive regulation of alcohol biosynthetic process 13 14 2 2 0 2 0 0 52 14 2481 0.74861 1.0 1.0 0.0 0 0 0 0 0 GO:1902948 9 negative regulation of tau-protein kinase activity 3 3 1 1 0 0 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:1902994 8 regulation of phospholipid efflux 2 2 1 1 0 1 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:1902995 8 positive regulation of phospholipid efflux 2 2 1 1 0 1 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:1903008 6 organelle disassembly 14 14 1 1 0 1 0 0 52 14 2481 0.74861 1.0 1.0 0.0 0 0 0 0 0 GO:1903037 7 regulation of leukocyte cell-cell adhesion 100 105 1 1 0 0 0 0 52 105 2390 0.1095 1.0 0.27385 0.0 0 0 0 0 0 GO:1903039 8 positive regulation of leukocyte cell-cell adhesion 73 77 1 1 0 0 0 0 52 77 2418 0.19934 1.0 0.40582 0.0 0 0 0 0 0 GO:1903046 3 meiotic cell cycle process 29 29 1 1 0 1 0 0 52 29 2466 0.54796 1.0 1.0 0.0 0 0 0 0 0 GO:1903051 9 negative regulation of proteolysis involved in cellular protein catabolic process 15 15 1 1 0 0 0 0 52 15 2480 0.73325 1.0 1.0 0.0 0 0 0 0 0 GO:1903053 6 regulation of extracellular matrix organization 15 16 1 1 0 0 0 0 52 16 2479 0.71819 1.0 1.0 0.0 0 0 0 0 0 GO:1903055 7 positive regulation of extracellular matrix organization 8 9 1 1 0 0 0 0 52 9 2486 0.83032 1.0 1.0 0.0 0 0 0 0 0 GO:1903076 8 regulation of protein localization to plasma membrane 27 29 2 2 1 1 0 0 52 29 2466 0.54796 1.0 1.0 0.0 0 0 0 0 0 GO:1903078 8 positive regulation of protein localization to plasma membrane 14 16 2 2 1 1 0 0 52 16 2479 0.71819 1.0 1.0 0.0 0 0 0 0 0 GO:1903131 6 mononuclear cell differentiation 8 8 2 1 0 1 0 0 52 8 2487 0.84768 1.0 1.0 0.0 0 0 0 0 0 GO:1903146 8 regulation of autophagy of mitochondrion 11 12 1 1 0 1 0 0 52 12 2483 0.7803 1.0 1.0 0.0 0 0 0 0 0 GO:1903209 7 positive regulation of oxidative stress-induced cell death 6 8 1 1 0 1 0 0 52 8 2487 0.84768 1.0 1.0 0.0 0 0 0 0 0 GO:1903214 8 regulation of protein targeting to mitochondrion 8 8 1 1 0 1 0 0 52 8 2487 0.84768 1.0 1.0 0.0 0 0 0 0 0 GO:1903311 7 regulation of mRNA metabolic process 28 31 2 2 1 0 0 0 52 31 2464 0.52556 1.0 1.0 0.0 0 0 0 0 0 GO:1903312 8 negative regulation of mRNA metabolic process 13 14 2 2 1 0 0 0 52 14 2481 0.74861 1.0 1.0 0.0 0 0 0 0 0 GO:1903313 8 positive regulation of mRNA metabolic process 7 9 1 1 0 0 0 0 52 9 2486 0.83032 1.0 1.0 0.0 0 0 0 0 0 GO:1903321 9 negative regulation of protein modification by small protein conjugation or removal 22 24 3 2 0 1 0 0 52 24 2471 0.60815 1.0 1.0 0.0 0 0 0 0 0 GO:1903363 8 negative regulation of cellular protein catabolic process 17 17 1 1 0 0 0 0 52 17 2478 0.70343 1.0 1.0 0.0 0 0 0 0 0 GO:1903426 6 regulation of reactive oxygen species biosynthetic process 44 48 3 2 0 1 0 0 52 48 2447 0.36808 1.0 0.62471 0.0 0 0 0 0 0 GO:1903428 7 positive regulation of reactive oxygen species biosynthetic process 30 33 3 2 0 1 0 0 52 33 2462 0.50406 1.0 1.0 0.0 0 0 0 0 0 GO:1903429 7 regulation of cell maturation 18 19 1 1 0 1 0 0 52 19 2476 0.67481 1.0 1.0 0.0 0 0 0 0 0 GO:1903431 8 positive regulation of cell maturation 11 11 1 1 0 1 0 0 52 11 2484 0.79664 1.0 1.0 0.0 0 0 0 0 0 GO:1903432 8 regulation of TORC1 signaling 5 6 1 1 0 0 0 0 52 6 2489 0.88348 1.0 1.0 0.0 0 0 0 0 0 GO:1903487 5 regulation of lactation 3 3 1 1 0 1 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:1903489 6 positive regulation of lactation 3 3 1 1 0 1 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:1903509 5 liposaccharide metabolic process 12 13 1 1 0 1 0 0 52 13 2482 0.7643 1.0 1.0 0.0 0 0 0 0 0 GO:1903510 7 mucopolysaccharide metabolic process 20 20 1 1 0 1 0 0 52 20 2475 0.66093 1.0 1.0 0.0 0 0 0 0 0 GO:1903522 6 regulation of blood circulation 63 68 2 2 0 1 0 0 52 68 2427 0.24132 1.0 0.40137 0.0 0 0 0 0 0 GO:1903524 6 positive regulation of blood circulation 30 32 1 1 0 0 0 0 52 32 2463 0.5147 1.0 1.0 0.0 0 0 0 0 0 GO:1903533 8 regulation of protein targeting 19 21 1 1 0 1 0 0 52 21 2474 0.64733 1.0 1.0 0.0 0 0 0 0 0 GO:1903538 6 regulation of meiotic cell cycle process involved in oocyte maturation 9 10 1 1 0 1 0 0 52 10 2485 0.81331 1.0 1.0 0.0 0 0 0 0 0 GO:1903573 6 negative regulation of response to endoplasmic reticulum stress 18 18 1 1 0 0 0 0 52 18 2477 0.68897 1.0 1.0 0.0 0 0 0 0 0 GO:1903578 5 regulation of ATP metabolic process 33 35 2 2 1 1 0 0 52 35 2460 0.48342 1.0 1.0 0.0 0 0 0 0 0 GO:1903580 6 positive regulation of ATP metabolic process 18 19 2 2 1 1 0 0 52 19 2476 0.67481 1.0 1.0 0.0 0 0 0 0 0 GO:1903699 7 tarsal gland development 1 1 1 1 0 1 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:1903747 7 regulation of establishment of protein localization to mitochondrion 9 9 1 1 0 1 0 0 52 9 2486 0.83032 1.0 1.0 0.0 0 0 0 0 0 GO:1903793 7 positive regulation of anion transport 25 26 1 1 0 1 0 0 52 26 2469 0.58334 1.0 1.0 0.0 0 0 0 0 0 GO:1903825 5 organic acid transmembrane transport 23 23 1 1 1 0 0 0 52 23 2472 0.62094 1.0 1.0 0.0 0 0 0 0 0 GO:1903827 6 regulation of cellular protein localization 137 147 7 6 1 2 0 0 52 147 2348 0.043998 1.0 0.071721 0.0 0 0 0 0 0 GO:1903828 6 negative regulation of cellular protein localization 29 31 1 1 0 0 0 0 52 31 2464 0.52556 1.0 1.0 0.0 0 0 0 0 0 GO:1903829 6 positive regulation of cellular protein localization 83 90 4 3 1 1 0 0 52 90 2405 0.15107 1.0 0.26035 0.0 0 0 0 0 0 GO:1903840 5 response to arsenite(3-) 1 1 1 1 1 0 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:1903841 6 cellular response to arsenite(3-) 1 1 1 1 1 0 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:1903842 5 response to arsenite ion 1 1 1 1 1 0 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:1903843 6 cellular response to arsenite ion 1 1 1 1 1 0 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:1903862 7 positive regulation of oxidative phosphorylation 4 4 1 1 1 0 0 0 52 4 2491 0.92076 1.0 1.0 0.0 0 0 0 0 0 GO:1903900 6 regulation of viral life cycle 36 38 1 1 0 0 0 0 52 38 2457 0.454 1.0 1.0 0.0 0 0 0 0 0 GO:1903901 6 negative regulation of viral life cycle 23 24 1 1 0 0 0 0 52 24 2471 0.60815 1.0 1.0 0.0 0 0 0 0 0 GO:1903943 9 regulation of hepatocyte apoptotic process 3 3 1 1 0 0 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:1903944 10 negative regulation of hepatocyte apoptotic process 3 3 1 1 0 0 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:1903964 8 monounsaturated fatty acid metabolic process 2 2 1 1 0 1 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:1903966 8 monounsaturated fatty acid biosynthetic process 2 2 1 1 0 1 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:1904019 6 epithelial cell apoptotic process 14 17 2 2 1 0 0 0 52 17 2478 0.70343 1.0 1.0 0.0 0 0 0 0 0 GO:1904026 7 regulation of collagen fibril organization 3 3 1 1 0 0 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:1904028 8 positive regulation of collagen fibril organization 1 1 1 1 0 0 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:1904037 9 positive regulation of epithelial cell apoptotic process 14 16 1 1 0 1 0 0 52 16 2479 0.71819 1.0 1.0 0.0 0 0 0 0 0 GO:1904146 7 positive regulation of meiotic cell cycle process involved in oocyte maturation 6 6 1 1 0 1 0 0 52 6 2489 0.88348 1.0 1.0 0.0 0 0 0 0 0 GO:1904152 8 regulation of retrograde protein transport, ER to cytosol 3 3 1 1 0 0 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:1904153 9 negative regulation of retrograde protein transport, ER to cytosol 2 2 1 1 0 0 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:1904182 6 regulation of pyruvate dehydrogenase activity 2 2 1 1 0 1 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:1904183 7 negative regulation of pyruvate dehydrogenase activity 2 2 1 1 0 1 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:1904245 6 regulation of polynucleotide adenylyltransferase activity 1 1 1 1 0 0 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:1904246 7 negative regulation of polynucleotide adenylyltransferase activity 1 1 1 1 0 0 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:1904262 9 negative regulation of TORC1 signaling 2 2 1 1 0 0 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:1904292 7 regulation of ERAD pathway 7 7 1 1 0 0 0 0 52 7 2488 0.8654 1.0 1.0 0.0 0 0 0 0 0 GO:1904293 8 negative regulation of ERAD pathway 3 3 1 1 0 0 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:1904375 7 regulation of protein localization to cell periphery 35 37 2 2 1 1 0 0 52 37 2458 0.46361 1.0 1.0 0.0 0 0 0 0 0 GO:1904377 7 positive regulation of protein localization to cell periphery 16 18 2 2 1 1 0 0 52 18 2477 0.68897 1.0 1.0 0.0 0 0 0 0 0 GO:1904407 5 positive regulation of nitric oxide metabolic process 25 28 2 1 0 0 0 0 52 28 2467 0.55952 1.0 1.0 0.0 0 0 0 0 0 GO:1904502 9 regulation of lipophagy 2 3 1 1 0 0 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:1904504 10 positive regulation of lipophagy 2 3 1 1 0 0 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:1904580 6 regulation of intracellular mRNA localization 1 1 1 1 0 0 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:1904582 6 positive regulation of intracellular mRNA localization 1 1 1 1 0 0 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:1904585 6 response to putrescine 1 1 1 1 1 0 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:1904586 6 cellular response to putrescine 1 1 1 1 1 0 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:1904619 5 response to dimethyl sulfoxide 1 1 1 1 1 0 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:1904620 6 cellular response to dimethyl sulfoxide 1 1 1 1 1 0 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:1904627 6 response to phorbol 13-acetate 12-myristate 3 3 1 1 1 0 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:1904628 6 cellular response to phorbol 13-acetate 12-myristate 3 3 1 1 1 0 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:1904640 6 response to methionine 3 3 2 2 1 1 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:1904645 6 response to amyloid-beta 27 28 2 2 0 1 0 0 52 28 2467 0.55952 1.0 1.0 0.0 0 0 0 0 0 GO:1904646 7 cellular response to amyloid-beta 23 24 2 2 0 1 0 0 52 24 2471 0.60815 1.0 1.0 0.0 0 0 0 0 0 GO:1904659 8 glucose transmembrane transport 5 7 2 1 0 0 0 0 52 7 2488 0.8654 1.0 1.0 0.0 0 0 0 0 0 GO:1904672 6 regulation of somatic stem cell population maintenance 2 2 1 1 1 0 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:1904760 6 regulation of myofibroblast differentiation 2 2 1 1 0 0 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:1904761 7 negative regulation of myofibroblast differentiation 1 1 1 1 0 0 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:1904814 7 regulation of protein localization to chromosome, telomeric region 3 3 1 0 0 0 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:1904816 7 positive regulation of protein localization to chromosome, telomeric region 3 3 1 0 0 0 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:1904879 9 positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel 1 1 1 1 0 1 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:1904950 5 negative regulation of establishment of protein localization 48 52 3 3 0 2 0 0 52 52 2443 0.33837 1.0 0.62564 0.0 0 0 0 0 0 GO:1904994 8 regulation of leukocyte adhesion to vascular endothelial cell 12 13 1 1 0 0 0 0 52 13 2482 0.7643 1.0 1.0 0.0 0 0 0 0 0 GO:1904996 9 positive regulation of leukocyte adhesion to vascular endothelial cell 10 11 1 1 0 0 0 0 52 11 2484 0.79664 1.0 1.0 0.0 0 0 0 0 0 GO:1905039 6 carboxylic acid transmembrane transport 23 23 1 1 1 0 0 0 52 23 2472 0.62094 1.0 1.0 0.0 0 0 0 0 0 GO:1905206 7 positive regulation of hydrogen peroxide-induced cell death 2 4 1 1 0 1 0 0 52 4 2491 0.92076 1.0 1.0 0.0 0 0 0 0 0 GO:1905207 6 regulation of cardiocyte differentiation 23 24 2 2 0 2 0 0 52 24 2471 0.60815 1.0 1.0 0.0 0 0 0 0 0 GO:1905208 6 negative regulation of cardiocyte differentiation 9 9 1 1 0 1 0 0 52 9 2486 0.83032 1.0 1.0 0.0 0 0 0 0 0 GO:1905209 6 positive regulation of cardiocyte differentiation 12 13 1 1 0 1 0 0 52 13 2482 0.7643 1.0 1.0 0.0 0 0 0 0 0 GO:1905269 9 positive regulation of chromatin organization 25 25 2 2 0 1 0 0 52 25 2470 0.59562 1.0 1.0 0.0 0 0 0 0 0 GO:1905475 7 regulation of protein localization to membrane 44 49 2 2 1 1 0 0 52 49 2446 0.36042 1.0 0.62471 0.0 0 0 0 0 0 GO:1905477 7 positive regulation of protein localization to membrane 26 30 2 2 1 1 0 0 52 30 2465 0.53665 1.0 1.0 0.0 0 0 0 0 0 GO:1905508 9 protein localization to microtubule organizing center 4 4 1 1 0 1 0 0 52 4 2491 0.92076 1.0 1.0 0.0 0 0 0 0 0 GO:1905634 7 regulation of protein localization to chromatin 1 2 1 1 0 0 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:1905643 8 positive regulation of DNA methylation 1 1 1 1 1 0 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:1905719 5 protein localization to perinuclear region of cytoplasm 1 1 1 1 0 1 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:1905818 6 regulation of chromosome separation 17 17 1 1 0 0 0 0 52 17 2478 0.70343 1.0 1.0 0.0 0 0 0 0 0 GO:1905820 7 positive regulation of chromosome separation 3 3 1 1 0 0 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:1905879 5 regulation of oogenesis 12 13 1 1 0 1 0 0 52 13 2482 0.7643 1.0 1.0 0.0 0 0 0 0 0 GO:1905881 6 positive regulation of oogenesis 7 7 1 1 0 1 0 0 52 7 2488 0.8654 1.0 1.0 0.0 0 0 0 0 0 GO:1905897 6 regulation of response to endoplasmic reticulum stress 26 26 1 1 0 0 0 0 52 26 2469 0.58334 1.0 1.0 0.0 0 0 0 0 0 GO:1990089 4 response to nerve growth factor 24 25 1 1 0 1 0 0 52 25 2470 0.59562 1.0 1.0 0.0 0 0 0 0 0 GO:1990090 6 cellular response to nerve growth factor stimulus 22 23 1 1 0 1 0 0 52 23 2472 0.62094 1.0 1.0 0.0 0 0 0 0 0 GO:1990138 5 neuron projection extension 14 15 1 1 0 1 0 0 52 15 2480 0.73325 1.0 1.0 0.0 0 0 0 0 0 GO:1990253 7 cellular response to leucine starvation 2 3 1 1 0 0 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:1990539 7 fructose import across plasma membrane 1 1 1 0 0 0 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:1990637 6 response to prolactin 4 4 1 1 1 0 0 0 52 4 2491 0.92076 1.0 1.0 0.0 0 0 0 0 0 GO:1990646 7 cellular response to prolactin 3 3 1 1 1 0 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:1990785 5 response to water-immersion restraint stress 4 4 1 1 0 1 0 0 52 4 2491 0.92076 1.0 1.0 0.0 0 0 0 0 0 GO:1990823 6 response to leukemia inhibitory factor 27 33 1 1 0 0 0 0 52 33 2462 0.50406 1.0 1.0 0.0 0 0 0 0 0 GO:1990830 7 cellular response to leukemia inhibitory factor 26 32 1 1 0 0 0 0 52 32 2463 0.5147 1.0 1.0 0.0 0 0 0 0 0 GO:1990839 6 response to endothelin 3 3 1 1 1 0 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:1990840 4 response to lectin 1 1 1 1 1 0 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:1990858 5 cellular response to lectin 1 1 1 1 1 0 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:1990859 7 cellular response to endothelin 2 2 1 1 1 0 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:1990928 5 response to amino acid starvation 14 16 1 1 0 0 0 0 52 16 2479 0.71819 1.0 1.0 0.0 0 0 0 0 0 GO:2000001 7 regulation of DNA damage checkpoint 3 3 1 0 0 0 0 0 52 3 2492 0.93997 1.0 1.0 0.0 0 0 0 0 0 GO:2000027 6 regulation of animal organ morphogenesis 54 58 1 1 1 0 0 0 52 58 2437 0.29816 1.0 0.63115 0.0 0 0 0 0 0 GO:2000036 5 regulation of stem cell population maintenance 7 7 1 1 1 0 0 0 52 7 2488 0.8654 1.0 1.0 0.0 0 0 0 0 0 GO:2000106 8 regulation of leukocyte apoptotic process 31 33 1 1 1 0 0 0 52 33 2462 0.50406 1.0 1.0 0.0 0 0 0 0 0 GO:2000108 9 positive regulation of leukocyte apoptotic process 14 14 1 1 1 0 0 0 52 14 2481 0.74861 1.0 1.0 0.0 0 0 0 0 0 GO:2000116 8 regulation of cysteine-type endopeptidase activity 91 94 1 1 1 0 0 0 52 94 2401 0.13867 1.0 0.26169 0.0 0 0 0 0 0 GO:2000142 8 regulation of DNA-templated transcription, initiation 10 12 1 1 1 0 0 0 52 12 2483 0.7803 1.0 1.0 0.0 0 0 0 0 0 GO:2000144 9 positive regulation of DNA-templated transcription, initiation 9 10 1 1 1 0 0 0 52 10 2485 0.81331 1.0 1.0 0.0 0 0 0 0 0 GO:2000171 9 negative regulation of dendrite development 8 8 1 1 0 1 0 0 52 8 2487 0.84768 1.0 1.0 0.0 0 0 0 0 0 GO:2000278 7 regulation of DNA biosynthetic process 42 46 1 1 1 0 0 0 52 46 2449 0.38388 1.0 1.0 0.0 0 0 0 0 0 GO:2000322 7 regulation of glucocorticoid receptor signaling pathway 4 4 1 0 0 0 0 0 52 4 2491 0.92076 1.0 1.0 0.0 0 0 0 0 0 GO:2000323 8 negative regulation of glucocorticoid receptor signaling pathway 2 2 1 0 0 0 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:2000353 10 positive regulation of endothelial cell apoptotic process 8 10 1 1 0 1 0 0 52 10 2485 0.81331 1.0 1.0 0.0 0 0 0 0 0 GO:2000378 7 negative regulation of reactive oxygen species metabolic process 32 33 1 1 0 1 0 0 52 33 2462 0.50406 1.0 1.0 0.0 0 0 0 0 0 GO:2000479 9 regulation of cAMP-dependent protein kinase activity 7 8 1 1 0 0 0 0 52 8 2487 0.84768 1.0 1.0 0.0 0 0 0 0 0 GO:2000573 8 positive regulation of DNA biosynthetic process 29 33 1 1 1 0 0 0 52 33 2462 0.50406 1.0 1.0 0.0 0 0 0 0 0 GO:2000637 6 positive regulation of gene silencing by miRNA 9 10 1 1 0 0 0 0 52 10 2485 0.81331 1.0 1.0 0.0 0 0 0 0 0 GO:2000679 7 positive regulation of transcription regulatory region DNA binding 11 11 1 1 0 0 0 0 52 11 2484 0.79664 1.0 1.0 0.0 0 0 0 0 0 GO:2000725 7 regulation of cardiac muscle cell differentiation 21 22 2 2 0 2 0 0 52 22 2473 0.634 1.0 1.0 0.0 0 0 0 0 0 GO:2000726 7 negative regulation of cardiac muscle cell differentiation 8 8 1 1 0 1 0 0 52 8 2487 0.84768 1.0 1.0 0.0 0 0 0 0 0 GO:2000727 7 positive regulation of cardiac muscle cell differentiation 12 13 1 1 0 1 0 0 52 13 2482 0.7643 1.0 1.0 0.0 0 0 0 0 0 GO:2000831 6 regulation of steroid hormone secretion 7 7 1 0 0 0 0 0 52 7 2488 0.8654 1.0 1.0 0.0 0 0 0 0 0 GO:2000832 6 negative regulation of steroid hormone secretion 2 2 1 0 0 0 0 0 52 2 2493 0.95958 1.0 1.0 0.0 0 0 0 0 0 GO:2000846 7 regulation of corticosteroid hormone secretion 4 4 1 0 0 0 0 0 52 4 2491 0.92076 1.0 1.0 0.0 0 0 0 0 0 GO:2000847 7 negative regulation of corticosteroid hormone secretion 1 1 1 0 0 0 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:2000849 8 regulation of glucocorticoid secretion 1 1 1 0 0 0 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:2000850 8 negative regulation of glucocorticoid secretion 1 1 1 0 0 0 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:2001014 6 regulation of skeletal muscle cell differentiation 9 9 1 1 0 1 0 0 52 9 2486 0.83032 1.0 1.0 0.0 0 0 0 0 0 GO:2001025 6 positive regulation of response to drug 15 17 1 1 0 1 0 0 52 17 2478 0.70343 1.0 1.0 0.0 0 0 0 0 0 GO:2001040 6 positive regulation of cellular response to drug 3 5 1 1 0 1 0 0 52 5 2490 0.90193 1.0 1.0 0.0 0 0 0 0 0 GO:2001056 9 positive regulation of cysteine-type endopeptidase activity 48 51 1 1 1 0 0 0 52 51 2444 0.34556 1.0 0.62518 0.0 0 0 0 0 0 GO:2001138 7 regulation of phospholipid transport 4 4 1 1 0 1 0 0 52 4 2491 0.92076 1.0 1.0 0.0 0 0 0 0 0 GO:2001140 7 positive regulation of phospholipid transport 4 4 1 1 0 1 0 0 52 4 2491 0.92076 1.0 1.0 0.0 0 0 0 0 0 GO:2001169 6 regulation of ATP biosynthetic process 6 6 1 1 1 0 0 0 52 6 2489 0.88348 1.0 1.0 0.0 0 0 0 0 0 GO:2001171 7 positive regulation of ATP biosynthetic process 5 5 1 1 1 0 0 0 52 5 2490 0.90193 1.0 1.0 0.0 0 0 0 0 0 GO:2001252 8 positive regulation of chromosome organization 43 43 4 3 0 1 0 0 52 43 2452 0.40883 1.0 1.0 0.0 0 0 0 0 0 GO:2001256 9 regulation of store-operated calcium entry 4 4 1 1 1 0 0 0 52 4 2491 0.92076 1.0 1.0 0.0 0 0 0 0 0 GO:2001293 8 malonyl-CoA metabolic process 1 1 1 0 0 0 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:2001295 8 malonyl-CoA biosynthetic process 1 1 1 0 0 0 0 0 52 1 2494 0.97958 1.0 1.0 0.0 0 0 0 0 0 GO:0010949 8 negative regulation of intestinal phytosterol absorption 2 2 1 1 1 1 1 1 51 1 2494 0.99959 0.040423 0.040423 50.0 114628 abcg5 ABCG5_7947 360.968 360.968 360.968 360.968 273.647 273.647 273.647 273.647 528.588 528.588 528.588 528.588 0.0 360.968 0.0 360.968 360.968 273.647 528.588 0 1 0 1 114628 ABCG5_7947 360.968 360.968 273.647 273.647 528.588 528.588 360.968 273.647 528.588 0 Linear,1(1) 2.1518702507019043 2.1518702507019043 2.1518702507019043 2.1518702507019043 0.0 2.1518702507019043 360.968 360.968 273.647 273.647 528.588 528.588 DOWN 0.0 1.0 0.0 GO:0045796 8 negative regulation of intestinal cholesterol absorption 2 2 1 1 1 1 1 1 51 1 2494 0.99959 0.040423 0.040423 50.0 114628 abcg5 ABCG5_7947 360.968 360.968 360.968 360.968 273.647 273.647 273.647 273.647 528.588 528.588 528.588 528.588 0.0 360.968 0.0 360.968 360.968 273.647 528.588 0 1 0 1 114628 ABCG5_7947 360.968 360.968 273.647 273.647 528.588 528.588 360.968 273.647 528.588 0 Linear,1(1) 2.1518702507019043 2.1518702507019043 2.1518702507019043 2.1518702507019043 0.0 2.1518702507019043 360.968 360.968 273.647 273.647 528.588 528.588 DOWN 0.0 1.0 0.0 GO:0031670 5 cellular response to nutrient 30 32 2 2 2 2 2 2 50 30 2465 0.97376 0.13771 0.13771 6.25 59107;24539 ltbp1;lpl LTBP1_33264;LPL_32544 884.106 884.106 769.435 162.1692834108848 872.2211331940775 161.29592792135597 475.6785 475.6785 444.211 44.50176527397591 472.4171083123426 44.26210298911884 3624.54 3624.54 2183.16 2038.4191445333322 3475.1507968298833 2027.4413285598148 0.5 884.106 998.777;769.435 507.146;444.211 5065.92;2183.16 0 2 0 2 59107;24539 LTBP1_33264;LPL_32544 884.106 884.106 162.1692834108848 475.6785 475.6785 44.50176527397591 3624.54 3624.54 2038.4191445333322 998.777;769.435 507.146;444.211 5065.92;2183.16 0 Exp 2,2(1) 1.66631559928624 3.3329694271087646 1.6427439451217651 1.6902254819869995 0.03357451669856627 1.6664847135543823 659.35084 1108.86116 414.0022 537.3548 799.4351999999999 6449.6448 DOWN 0.0 1.0 0.0 GO:0042493 4 response to drug 436 472 37 35 24 30 20 20 32 452 2043 0.99983 5.3357E-4 8.0732E-4 4.24 24522;286954;170698;24614;24314;316351;83619;24539;29200;24484;24424;300850;116686;24330;24296;58919;54232;25612;24188;114628 zfp354a;ugt2b1;slco1a2;orm1;nqo1;npas2;nfe2l2;lpl;inhba;igfbp3;gstm2;gsta4;gsr;egr1;cyp1a1;ccnd1;car3;asns;aldh1a1;abcg5 ZFP354A_10203;UGT2B10_33303,UGT2B1_33224;SLCO1A2_9886;ORM1_9400;NQO1_33055;NPAS2_9350;NFE2L2_9301;LPL_32544;INHBA_33300;IGFBP3_8881;GSTM2_8759;GSTA4_8757;GSR_8755;EGR1_8533;CYP1A1_8415;CCND1_8224;CAR3_8196;ASNS_8091;ALDH1A1_8022;ABCG5_7947 155.06537299999997 81.57055 3.26713 205.47761588978227 184.43286371361546 231.1983672754239 95.68900634999999 55.15975 0.808077 130.1859018576 113.76907693646017 144.29026752119816 337.2733125 146.515 6.6682 509.40922440566794 415.47917674998104 598.3011333490001 3.26713;25.4966;440.994;56.9823;24.1117;134.458;6.6423;769.435;130.168;44.9033;3.28268;105.355;74.6342;8.26335;100.909;512.733;55.21;154.987;88.5069;360.968 1.71987;11.3392;299.351;16.0812;16.4151;56.7249;3.4063;444.211;89.164;18.8755;0.808077;75.6422;57.2867;1.51678;73.3629;330.024;24.6611;53.5946;65.9487;273.647 6.6682;63.97775;772.521;262.985;37.0434;320.448;13.4683;2183.16;231.33;122.765;13.1174;172.041;106.529;45.9052;159.385;1002.56;106.714;462.615;133.645;528.588 11 10 10 286954;24614;24314;83619;24424;300850;116686;24296;25612;24188 UGT2B10_33303,UGT2B1_33224;ORM1_9400;NQO1_33055;NFE2L2_9301;GSTM2_8759;GSTA4_8757;GSR_8755;CYP1A1_8415;ASNS_8091;ALDH1A1_8022 64.090768 65.80825 49.62534247624802 37.3884977 35.00485 30.362864596555514 142.480685 120.087 137.51614753975468 25.4966;56.9823;24.1117;6.6423;3.28268;105.355;74.6342;100.909;154.987;88.5069 11.3392;16.0812;16.4151;3.4063;0.808077;75.6422;57.2867;73.3629;53.5946;65.9487 63.97775;262.985;37.0434;13.4683;13.1174;172.041;106.529;159.385;462.615;133.645 10 24522;170698;316351;24539;29200;24484;24330;58919;54232;114628 ZFP354A_10203;SLCO1A2_9886;NPAS2_9350;LPL_32544;INHBA_33300;IGFBP3_8881;EGR1_8533;CCND1_8224;CAR3_8196;ABCG5_7947 246.03997799999996 132.313 261.30193590347733 153.989515 72.94445 165.2415382642778 532.0659400000001 275.889 666.781475798101 3.26713;440.994;134.458;769.435;130.168;44.9033;8.26335;512.733;55.21;360.968 1.71987;299.351;56.7249;444.211;89.164;18.8755;1.51678;330.024;24.6611;273.647 6.6682;772.521;320.448;2183.16;231.33;122.765;45.9052;1002.56;106.714;528.588 0 Exp 2,3(0.15);Exp 4,8(0.39);Exp 5,1(0.05);Hill,3(0.15);Linear,1(0.05);Poly 2,5(0.24) 2.1967769729731006 51.1693434715271 1.5423688888549805 6.495501518249512 1.3726738374686593 1.8888624906539917 65.01083727110773 245.1199087288922 38.6325192019209 152.7454934980791 114.01487628924232 560.5317487107575 CONFLICT 0.5 0.5 0.0 GO:0032879 4 regulation of localization 652 690 29 27 14 18 10 10 42 680 1815 0.12731 0.93031 0.26882 1.45 246273;170698;24614;83619;24539;29200;24484;24424;24330;114628 trib3;slco1a2;orm1;nfe2l2;lpl;inhba;igfbp3;gstm2;egr1;abcg5 TRIB3_10079;SLCO1A2_9886;ORM1_9400;NFE2L2_9301;LPL_32544;INHBA_33300;IGFBP3_8881;GSTM2_8759;EGR1_8533;ABCG5_7947 183.85338299999998 50.942800000000005 3.28268 258.4996827215414 240.04658454387186 290.4835378091628 115.3525547 17.47835 0.808077 162.40431462146753 147.7382083829534 179.85666621944128 423.28308 177.0475 13.1174 666.1983768576273 582.8786849673802 781.9243702131474 16.8949;440.994;56.9823;6.6423;769.435;130.168;44.9033;3.28268;8.26335;360.968 6.46469;299.351;16.0812;3.4063;444.211;89.164;18.8755;0.808077;1.51678;273.647 58.9909;772.521;262.985;13.4683;2183.16;231.33;122.765;13.1174;45.9052;528.588 4 6 4 246273;24614;83619;24424 TRIB3_10079;ORM1_9400;NFE2L2_9301;GSTM2_8759 20.950544999999998 11.7686 24.709073592402586 6.69006675 4.9354949999999995 6.673956994322703 87.1404 36.229600000000005 119.19270188343471 16.8949;56.9823;6.6423;3.28268 6.46469;16.0812;3.4063;0.808077 58.9909;262.985;13.4683;13.1174 6 170698;24539;29200;24484;24330;114628 SLCO1A2_9886;LPL_32544;INHBA_33300;IGFBP3_8881;EGR1_8533;ABCG5_7947 292.45527500000003 245.568 290.74098251232436 187.79421333333335 181.4055 178.05949510200534 647.3782 379.959 799.8102841656388 440.994;769.435;130.168;44.9033;8.26335;360.968 299.351;444.211;89.164;18.8755;1.51678;273.647 772.521;2183.16;231.33;122.765;45.9052;528.588 0 Exp 2,2(0.2);Exp 4,4(0.4);Hill,2(0.2);Linear,1(0.1);Poly 2,1(0.1) 1.957068940989621 21.1974276304245 1.5423688888549805 5.289852619171143 1.1401060909523264 1.6814804077148438 23.633619721134977 344.0731462788651 14.693317635684949 216.01179176431503 10.369048102047259 836.1971118979527 DOWN 0.4 0.6 0.0 GO:0006042 8 glucosamine biosynthetic process 1 1 1 1 1 1 1 1 51 0 2495 1.0 0.020416 0.020416 100.0 297417 gfpt1 GFPT1_8705 981.5 981.5 981.5 981.5 554.87 554.87 554.87 554.87 4240.48 4240.48 4240.48 4240.48 0.0 981.5 0.0 981.5 981.5 554.87 4240.48 1 0 1 297417 GFPT1_8705 981.5 981.5 554.87 554.87 4240.48 4240.48 981.5 554.87 4240.48 0 0 Linear,1(1) 1.5232417583465576 1.5232417583465576 1.5232417583465576 1.5232417583465576 0.0 1.5232417583465576 981.5 981.5 554.87 554.87 4240.48 4240.48 UP 1.0 0.0 0.0 GO:0010468 6 regulation of gene expression 723 775 39 35 20 27 18 18 34 757 1738 0.79435 0.29999 0.54289 2.32 24522;308843;246273;170698;360918;24614;316351;83619;59107;24539;29200;494344;25587;297417;24330;289185;25695;58919 zfp354a;tsku;trib3;slco1a2;pf4;orm1;npas2;nfe2l2;ltbp1;lpl;inhba;ier2;id2;gfpt1;egr1;creg1;cebpd;ccnd1 ZFP354A_10203;TSKU_10094;TRIB3_10079;SLCO1A2_9886;PF4_32963;ORM1_9400;NPAS2_9350;NFE2L2_9301;LTBP1_33264;LPL_32544;INHBA_33300;IER2_32643;ID2_8861;GFPT1_8705;EGR1_8533;CREG1_8380;CEBPD_8283;CCND1_8224 271.79949611111107 112.2448 2.99674 347.758005378028 285.1545166370444 350.8793583208357 159.51612133333333 62.985299999999995 0.998544 198.93992952500594 163.18236456107903 198.66736170831896 879.2265833333333 247.15750000000003 6.6682 1485.1025132270688 924.7795170538616 1494.398248315504 3.26713;6.12626;16.8949;440.994;179.631;56.9823;134.458;6.6423;998.777;769.435;130.168;543.54;2.99674;981.5;8.26335;94.3216;5.66035;512.733 1.71987;1.46625;6.46469;299.351;110.795;16.0812;56.7249;3.4063;507.146;444.211;89.164;375.947;0.998544;554.87;1.51678;69.2457;2.15795;330.024 6.6682;41.3339;58.9909;772.521;426.677;262.985;320.448;13.4683;5065.92;2183.16;231.33;978.946;10.914;4240.48;45.9052;147.421;16.35;1002.56 7 11 7 246273;360918;24614;83619;25587;297417;289185 TRIB3_10079;PF4_32963;ORM1_9400;NFE2L2_9301;ID2_8861;GFPT1_8705;CREG1_8380 191.28126285714285 56.9823 354.0178857311247 108.83734771428571 16.0812 200.97480574737625 737.2766 147.421 1552.0610435066535 16.8949;179.631;56.9823;6.6423;2.99674;981.5;94.3216 6.46469;110.795;16.0812;3.4063;0.998544;554.87;69.2457 58.9909;426.677;262.985;13.4683;10.914;4240.48;147.421 11 24522;308843;170698;316351;59107;24539;29200;494344;24330;25695;58919 ZFP354A_10203;TSKU_10094;SLCO1A2_9886;NPAS2_9350;LTBP1_33264;LPL_32544;INHBA_33300;IER2_32643;EGR1_8533;CEBPD_8283;CCND1_8224 323.0383718181818 134.458 350.6667630737206 191.76625 89.164 200.26139013323882 969.5583909090909 320.448 1510.2924683790227 3.26713;6.12626;440.994;134.458;998.777;769.435;130.168;543.54;8.26335;5.66035;512.733 1.71987;1.46625;299.351;56.7249;507.146;444.211;89.164;375.947;1.51678;2.15795;330.024 6.6682;41.3339;772.521;320.448;5065.92;2183.16;231.33;978.946;45.9052;16.35;1002.56 0 Exp 2,4(0.23);Exp 4,5(0.28);Hill,4(0.23);Linear,2(0.12);Poly 2,3(0.17) 1.9972676729696606 39.97264552116394 1.5232417583465576 6.495501518249512 1.3731720783829358 1.6814804077148438 111.14349415216631 432.4554980700559 67.61056283227505 251.42167983439163 193.14422553143766 1565.3089411352294 DOWN 0.3888888888888889 0.6111111111111112 0.0 GO:0032760 8 positive regulation of tumor necrosis factor production 43 45 4 3 3 3 3 3 49 42 2453 0.98759 0.062447 0.062447 6.67 360918;24614;24539 pf4;orm1;lpl PF4_32963;ORM1_9400;LPL_32544 335.3494333333333 179.631 56.9823 380.8981298118479 396.25769330628805 429.1960079428072 190.3624 110.795 16.0812 224.88221310072524 221.06468756436263 257.1404508698114 957.6073333333334 426.677 262.985 1064.5108133768924 1168.6127350600718 1164.2703040000936 1.5 474.53299999999996 179.631;56.9823;769.435 110.795;16.0812;444.211 426.677;262.985;2183.16 2 1 2 360918;24614 PF4_32963;ORM1_9400 118.30665 118.30665 86.72572747371449 63.4381 63.4381 66.97277025194643 344.831 344.831 115.74772322598835 179.631;56.9823 110.795;16.0812 426.677;262.985 1 24539 LPL_32544 769.435 769.435 444.211 444.211 2183.16 2183.16 769.435 444.211 2183.16 0 Exp 2,1(0.34);Exp 4,1(0.34);Poly 2,1(0.34) 1.7078550033826472 5.134706139564514 1.5846891403198242 1.8597915172576904 0.13878753397836552 1.6902254819869995 -95.67737671682966 766.3762433834963 -64.1157802885385 444.8405802885385 -247.00005179716266 2162.2147184638293 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0001932 8 regulation of protein phosphorylation 371 395 13 13 8 7 5 5 47 390 2105 0.16007 0.92402 0.33125 1.27 246273;29200;24484;24330;58919 trib3;inhba;igfbp3;egr1;ccnd1 TRIB3_10079;INHBA_33300;IGFBP3_8881;EGR1_8533;CCND1_8224 142.59251 44.9033 8.26335 212.4533742510471 162.1430644101134 229.84597804602242 89.208994 18.8755 1.51678 139.17184858849356 100.27220602910285 151.11457897810214 292.31021999999996 122.765 45.9052 403.75495594871893 334.93779224687773 435.6721373363123 16.8949;130.168;44.9033;8.26335;512.733 6.46469;89.164;18.8755;1.51678;330.024 58.9909;231.33;122.765;45.9052;1002.56 1 4 1 246273 TRIB3_10079 16.8949 16.8949 6.46469 6.46469 58.9909 58.9909 16.8949 6.46469 58.9909 4 29200;24484;24330;58919 INHBA_33300;IGFBP3_8881;EGR1_8533;CCND1_8224 174.0169125 87.53565 231.51377458874293 109.89507 54.01975 151.56620000580472 350.64005 177.0475 441.21985315563103 130.168;44.9033;8.26335;512.733 89.164;18.8755;1.51678;330.024 231.33;122.765;45.9052;1002.56 0 Exp 2,1(0.2);Exp 4,2(0.4);Hill,1(0.2);Poly 2,1(0.2) 2.1914387420444257 12.405099391937256 1.555469274520874 5.289852619171143 1.5959433839938704 1.6548216342926025 -43.63108325482153 328.81610325482154 -32.78050988728647 211.19849788728646 -61.5966028794773 646.2170428794773 DOWN 0.2 0.8 0.0 GO:0016311 6 dephosphorylation 44 50 4 4 2 1 1 1 51 49 2446 0.72805 0.64709 1.0 2.0 54232 car3 CAR3_8196 55.21 55.21 55.21 55.21 24.6611 24.6611 24.6611 24.6611 106.714 106.714 106.714 106.714 55.21 24.6611 106.714 0 1 0 1 54232 CAR3_8196 55.21 55.21 24.6611 24.6611 106.714 106.714 55.21 24.6611 106.714 0 Exp 5,1(1) 2.754816055297852 2.7548160552978516 2.7548160552978516 2.7548160552978516 0.0 2.7548160552978516 55.21 55.21 24.6611 24.6611 106.714 106.714 DOWN 0.0 1.0 0.0 GO:0042573 8 retinoic acid metabolic process 6 6 3 3 3 3 3 3 49 3 2492 1.0 1.5383E-4 1.5383E-4 50.0 499353;24296;24188 cyp2c24;cyp1a1;aldh1a1 CYP2C24_32875;CYP1A1_8415;ALDH1A1_8022 307.7836333333333 100.909 88.5069 369.11000190323114 315.4619716319515 371.14420258049995 200.8392 73.3629 65.9487 227.24655310276987 205.5504964246714 228.51324786559755 685.5933333333332 159.385 133.645 933.7997565368785 704.6121061678463 939.310383723481 0.0 88.5069 0.0 88.5069 733.935;100.909;88.5069 463.206;73.3629;65.9487 1763.75;159.385;133.645 2 1 2 24296;24188 CYP1A1_8415;ALDH1A1_8022 94.70795000000001 94.70795000000001 8.769609010953614 69.6558 69.6558 5.24263109707331 146.515 146.515 18.200928547741807 100.909;88.5069 73.3629;65.9487 159.385;133.645 1 499353 CYP2C24_32875 733.935 733.935 463.206 463.206 1763.75 1763.75 733.935 463.206 1763.75 0 Linear,1(0.34);Poly 2,2(0.67) 2.087405701332112 6.4099814891815186 1.7045893669128418 2.79919695854187 0.5825608526874854 1.9061951637268066 -109.90365422711767 725.4709208937843 -56.314482868345635 457.99288286834565 -371.10056664598346 1742.28723331265 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0045598 6 regulation of fat cell differentiation 37 42 6 6 4 3 3 3 49 39 2456 0.99025 0.052705 0.052705 7.14 246273;24539;25587 trib3;lpl;id2 TRIB3_10079;LPL_32544;ID2_8861 263.10888 16.8949 2.99674 438.5463425437922 521.6252253355327 435.89646886543693 150.558078 6.46469 0.998544 254.32557605828183 300.4537726385244 252.8599815225047 751.0216333333333 58.9909 10.914 1240.501137862196 1482.3524836170054 1232.7556116261994 1.5 393.16495 16.8949;769.435;2.99674 6.46469;444.211;0.998544 58.9909;2183.16;10.914 2 1 2 246273;25587 TRIB3_10079;ID2_8861 9.94582 9.94582 9.827483182015628 3.731617 3.731617 3.865148903555722 34.95245 34.95245 33.995502008427536 16.8949;2.99674 6.46469;0.998544 58.9909;10.914 1 24539 LPL_32544 769.435 769.435 444.211 444.211 2183.16 2183.16 769.435 444.211 2183.16 0 Exp 2,1(0.34);Exp 4,1(0.34);Hill,1(0.34) 1.9648487421224536 5.9371702671051025 1.6902254819869995 2.2692105770111084 0.2894948132767223 1.9777342081069946 -233.15302388277723 759.3707838827772 -137.23840400614907 438.3545600061491 -652.7375517812277 2154.7808184478945 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0006631 6 fatty acid metabolic process 129 145 19 17 10 14 9 9 43 136 2359 0.99947 0.0021946 0.0021946 6.21 24539;24424;25598;25315;499353;29277;24296;290277;24763 lpl;gstm2;fabp2;ephx1;cyp2c24;cyp2c11;cyp1a1;cryl1;acsm3 LPL_32544;GSTM2_8759;FABP2_32859;EPHX1_8567;CYP2C24_32875;CYP2C11_32593;CYP1A1_8415;CRYL1_8388;ACSM3_7976 271.68602 129.934 3.28268 302.7099873324691 405.00984467726107 327.2658582826382 165.92418633333332 73.3629 0.808077 190.91961726734942 251.53253113767238 197.66389534195062 648.2879888888888 319.535 13.1174 788.451400373987 986.3781341715353 905.9461278347613 6.5 597.03 769.435;3.28268;146.645;24.8784;733.935;129.934;100.909;76.0301;460.125 444.211;0.808077;95.8536;15.4867;463.206;45.3106;73.3629;23.2788;331.8 2183.16;13.1174;319.535;41.3795;1763.75;355.143;159.385;250.463;748.659 5 4 5 24424;25598;25315;24296;290277 GSTM2_8759;FABP2_32859;EPHX1_8567;CYP1A1_8415;CRYL1_8388 70.349036 76.0301 57.77701717790978 41.7580154 23.2788 40.723954478306574 156.77597999999998 159.385 131.55673538174324 3.28268;146.645;24.8784;100.909;76.0301 0.808077;95.8536;15.4867;73.3629;23.2788 13.1174;319.535;41.3795;159.385;250.463 4 24539;499353;29277;24763 LPL_32544;CYP2C24_32875;CYP2C11_32593;ACSM3_7976 523.35725 597.03 296.4666473207116 321.1319 388.0055 192.80794644664766 1262.6779999999999 1256.2045 853.6579272155794 769.435;733.935;129.934;460.125 444.211;463.206;45.3106;331.8 2183.16;1763.75;355.143;748.659 0 Exp 2,1(0.12);Exp 4,2(0.23);Hill,2(0.23);Linear,2(0.23);Poly 2,2(0.23) 1.8612987418707172 16.950507164001465 1.620619773864746 2.6370131969451904 0.3264642653737049 1.7059084177017212 73.91549494278686 469.45654505721313 41.19003638533174 290.658336281335 133.1664073112173 1163.4095704665601 CONFLICT 0.5555555555555556 0.4444444444444444 0.0 GO:0002376 2 immune system process 352 390 11 10 5 7 5 5 47 385 2110 0.16949 0.91857 0.33033 1.28 360918;24614;25587;24330;117517 pf4;orm1;id2;egr1;c7 PF4_32963;ORM1_9400;ID2_8861;EGR1_8533;C7_8179 52.343258000000006 13.8429 2.99674 74.3035743895899 40.19553649890256 45.014996169094 26.944076799999998 5.32886 0.998544 47.26498467683673 14.42033407074677 26.255663231966953 157.6755 45.9052 10.914 180.8924119397218 163.83440399162882 141.0345930739813 179.631;56.9823;2.99674;8.26335;13.8429 110.795;16.0812;0.998544;1.51678;5.32886 426.677;262.985;10.914;45.9052;41.8963 3 2 3 360918;24614;25587 PF4_32963;ORM1_9400;ID2_8861 79.87001333333333 56.9823 90.51409292291744 42.62491466666666 16.0812 59.516737383437324 233.52533333333335 262.985 209.44121373868455 179.631;56.9823;2.99674 110.795;16.0812;0.998544 426.677;262.985;10.914 2 24330;117517 EGR1_8533;C7_8179 11.053125000000001 11.053125000000001 3.945337640969398 3.4228199999999998 3.4228199999999998 2.6955476184256146 43.90075 43.90075 2.834720375098615 8.26335;13.8429 1.51678;5.32886 45.9052;41.8963 0 Exp 4,1(0.2);Hill,3(0.6);Poly 2,1(0.2) 2.377079454445113 13.173560738563538 1.5846891403198242 5.289852619171143 1.5177652997997202 1.9777342081069946 -12.786696576083493 117.47321257608348 -14.485508927614003 68.373662527614 -0.8836900467560724 316.2346900467561 UP 0.6 0.4 0.0 GO:0031323 5 regulation of cellular metabolic process 979 1054 47 43 21 31 16 16 36 1038 1457 0.075122 0.95851 0.12045 1.52 24522;246273;299270;363140;360918;316351;83619;29200;24484;494344;25587;297417;24330;289185;25695;58919 zfp354a;trib3;serpina6;rassf1;pf4;npas2;nfe2l2;inhba;igfbp3;ier2;id2;gfpt1;egr1;creg1;cebpd;ccnd1 ZFP354A_10203;TRIB3_10079;SERPINA6_32325;RASSF1_32475;PF4_32963;NPAS2_9350;NFE2L2_9301;INHBA_33300;IGFBP3_8881;IER2_32643;ID2_8861;GFPT1_8705;EGR1_8533;CREG1_8380;CEBPD_8283;CCND1_8224 214.838004375 69.61245 2.99674 309.24699235202485 221.49765591280578 293.9728696844814 129.197708375 37.8002 0.998544 184.60504208244674 131.76834410194303 178.15481876594535 537.746675 135.093 6.6682 1051.5152660644708 402.15062398111064 616.459251793155 3.26713;16.8949;15.8474;756.581;179.631;134.458;6.6423;130.168;44.9033;543.54;2.99674;981.5;8.26335;94.3216;5.66035;512.733 1.71987;6.46469;7.7531;437.5;110.795;56.7249;3.4063;89.164;18.8755;375.947;0.998544;554.87;1.51678;69.2457;2.15795;330.024 6.6682;58.9909;40.8362;940.187;426.677;320.448;13.4683;231.33;122.765;978.946;10.914;4240.48;45.9052;147.421;16.35;1002.56 7 9 7 246273;363140;360918;83619;25587;297417;289185 TRIB3_10079;RASSF1_32475;PF4_32963;NFE2L2_9301;ID2_8861;GFPT1_8705;CREG1_8380 291.2239342857143 94.3216 404.88265766938315 169.0400334285714 69.2457 229.63381275753224 834.0197428571428 147.421 1538.6176888901628 16.8949;756.581;179.631;6.6423;2.99674;981.5;94.3216 6.46469;437.5;110.795;3.4063;0.998544;554.87;69.2457 58.9909;940.187;426.677;13.4683;10.914;4240.48;147.421 9 24522;299270;316351;29200;24484;494344;24330;25695;58919 ZFP354A_10203;SERPINA6_32325;NPAS2_9350;INHBA_33300;IGFBP3_8881;IER2_32643;EGR1_8533;CEBPD_8283;CCND1_8224 155.42672555555555 44.9033 217.4611352679295 98.20923333333333 18.8755 147.91921331260852 307.3120666666666 122.765 401.3810335085727 3.26713;15.8474;134.458;130.168;44.9033;543.54;8.26335;5.66035;512.733 1.71987;7.7531;56.7249;89.164;18.8755;375.947;1.51678;2.15795;330.024 6.6682;40.8362;320.448;231.33;122.765;978.946;45.9052;16.35;1002.56 0 Exp 2,1(0.07);Exp 4,6(0.38);Hill,3(0.19);Linear,2(0.13);Poly 2,4(0.25) 2.0493008698686315 36.679927945137024 1.5232417583465576 6.495501518249512 1.4403429401588528 1.822007417678833 63.30697812250787 366.3690306274922 38.7412377546011 219.65417899539892 22.504194628409323 1052.9891553715906 CONFLICT 0.4375 0.5625 0.0 GO:0051050 5 positive regulation of transport 286 308 11 11 7 8 4 4 48 304 2191 0.22778 0.89096 0.39664 1.3 24614;83619;24539;24424 orm1;nfe2l2;lpl;gstm2 ORM1_9400;NFE2L2_9301;LPL_32544;GSTM2_8759 209.08557 31.8123 3.28268 374.372806859091 328.1081832222613 412.200903283418 116.12664425 9.743749999999999 0.808077 218.8246507773623 182.48190722617375 244.18535993528454 618.182675 138.22665 13.1174 1049.9369629382559 971.4355305037805 1135.1018448742354 56.9823;6.6423;769.435;3.28268 16.0812;3.4063;444.211;0.808077 262.985;13.4683;2183.16;13.1174 3 1 3 24614;83619;24424 ORM1_9400;NFE2L2_9301;GSTM2_8759 22.302426666666666 6.6423 30.08059129153105 6.765192333333332 3.4063 8.17182291924368 96.52356666666667 13.4683 144.15993678287785 56.9823;6.6423;3.28268 16.0812;3.4063;0.808077 262.985;13.4683;13.1174 1 24539 LPL_32544 769.435 769.435 444.211 444.211 2183.16 2183.16 769.435 444.211 2183.16 0 Exp 2,1(0.25);Exp 4,2(0.5);Hill,1(0.25) 1.6293266978283796 6.523191928863525 1.5423688888549805 1.7059084177017212 0.07983093615373528 1.6374573111534119 -157.79978072190914 575.9709207219091 -98.32151351181503 330.574802011815 -410.75554867949097 1647.120898679491 UP 0.75 0.25 0.0 GO:0051186 4 cofactor metabolic process 111 126 18 16 8 15 7 7 45 119 2376 0.99657 0.012779 0.012779 5.56 24424;300850;116686;24296;64392;24763;296925 gstm2;gsta4;gsr;cyp1a1;aldh1l1;acsm3;aass GSTM2_8759;GSTA4_8757;GSR_8755;CYP1A1_8415;ALDH1L1_32662;ACSM3_7976;AASS_7936 136.70134000000002 100.909 3.28268 154.08387814558623 131.43610785858408 144.83635417599973 93.74289957142858 73.3629 0.808077 112.0687201058512 90.8151700482791 106.3167968713309 353.9829142857143 159.385 13.1174 426.0184632361036 293.4943817937246 350.6452175270115 5.5 322.0775 3.28268;105.355;74.6342;100.909;184.03;460.125;28.5735 0.808077;75.6422;57.2867;73.3629;111.154;331.8;6.14642 13.1174;172.041;106.529;159.385;1150.07;748.659;128.079 5 2 5 24424;300850;116686;24296;64392 GSTM2_8759;GSTA4_8757;GSR_8755;CYP1A1_8415;ALDH1L1_32662 93.64217599999999 100.909 64.97325867914338 63.6507754 73.3629 40.26283079178519 320.22848 159.385 468.09501861646845 3.28268;105.355;74.6342;100.909;184.03 0.808077;75.6422;57.2867;73.3629;111.154 13.1174;172.041;106.529;159.385;1150.07 2 24763;296925 ACSM3_7976;AASS_7936 244.34925 244.34925 305.15299208122633 168.97321 168.97321 230.27185473567587 438.369 438.369 438.8163262687475 460.125;28.5735 331.8;6.14642 748.659;128.079 0 Hill,2(0.29);Linear,1(0.15);Poly 2,4(0.58) 1.79893858535244 12.643401026725769 1.6175053119659424 2.0709805488586426 0.17613178442030472 1.7613576650619507 22.554405667071606 250.84827433292838 10.721229889600366 176.7645692532568 38.38402014521415 669.5818084262144 UP 0.7142857142857143 0.2857142857142857 0.0 GO:0009256 7 10-formyltetrahydrofolate metabolic process 1 1 1 1 1 1 1 1 51 0 2495 1.0 0.020416 0.020416 100.0 64392 aldh1l1 ALDH1L1_32662 184.03 184.03 184.03 184.03 111.154 111.154 111.154 111.154 1150.07 1150.07 1150.07 1150.07 0.0 184.03 0.0 184.03 184.03 111.154 1150.07 1 0 1 64392 ALDH1L1_32662 184.03 184.03 111.154 111.154 1150.07 1150.07 184.03 111.154 1150.07 0 0 Poly 2,1(1) 1.7613576650619507 1.7613576650619507 1.7613576650619507 1.7613576650619507 0.0 1.7613576650619507 184.03 184.03 111.154 111.154 1150.07 1150.07 UP 1.0 0.0 0.0 GO:0009258 7 10-formyltetrahydrofolate catabolic process 1 1 1 1 1 1 1 1 51 0 2495 1.0 0.020416 0.020416 100.0 64392 aldh1l1 ALDH1L1_32662 184.03 184.03 184.03 184.03 111.154 111.154 111.154 111.154 1150.07 1150.07 1150.07 1150.07 0.0 184.03 0.0 184.03 184.03 111.154 1150.07 1 0 1 64392 ALDH1L1_32662 184.03 184.03 111.154 111.154 1150.07 1150.07 184.03 111.154 1150.07 0 0 Poly 2,1(1) 1.7613576650619507 1.7613576650619507 1.7613576650619507 1.7613576650619507 0.0 1.7613576650619507 184.03 184.03 111.154 111.154 1150.07 1150.07 UP 1.0 0.0 0.0 GO:1901135 4 carbohydrate derivative metabolic process 159 175 15 12 4 12 4 4 48 171 2324 0.71568 0.48449 0.77921 2.29 305291;297417;24763;296925 srd5a3;gfpt1;acsm3;aass SRD5A3_9939;GFPT1_8705;ACSM3_7976;AASS_7936 409.851875 314.66700000000003 28.5735 421.3435488387861 228.0560344571671 281.66801979654883 249.590855 218.6735 6.14642 244.92687683557875 145.32876166030536 183.0470398295107 1394.10725 603.935 128.079 1914.4450722017546 604.4003941899915 1037.6755561322127 169.209;981.5;460.125;28.5735 105.547;554.87;331.8;6.14642 459.211;4240.48;748.659;128.079 2 2 2 305291;297417 SRD5A3_9939;GFPT1_8705 575.3545 575.3545 574.3764743968019 330.2085 330.2085 317.7193402430831 2349.8455 2349.8455 2673.7609513904745 169.209;981.5 105.547;554.87 459.211;4240.48 2 24763;296925 ACSM3_7976;AASS_7936 244.34925 244.34925 305.15299208122633 168.97321 168.97321 230.27185473567587 438.369 438.369 438.8163262687475 460.125;28.5735 331.8;6.14642 748.659;128.079 0 Hill,1(0.25);Linear,2(0.5);Poly 2,1(0.25) 1.5727027391000428 6.293480157852173 1.5232417583465576 1.620619773864746 0.052900603873005304 1.5748093128204346 -3.0648028620102536 822.7685528620102 9.56251570113281 489.6191942988671 -482.04892075771977 3270.2634207577194 CONFLICT 0.5 0.5 0.0 GO:0050769 7 positive regulation of neurogenesis 132 142 4 4 3 3 2 2 50 140 2355 0.43812 0.79695 1.0 1.41 83619;25587 nfe2l2;id2 NFE2L2_9301;ID2_8861 4.81952 4.81952 2.99674 2.57780019722243 5.3136751918158565 2.4812648285910273 2.202422 2.202422 0.998544 1.7025405950425976 2.528793017902813 1.638782595439117 12.19115 12.19115 10.914 1.8061628511847745 12.537385038363169 1.7385243286820398 6.6423;2.99674 3.4063;0.998544 13.4683;10.914 2 0 2 83619;25587 NFE2L2_9301;ID2_8861 4.81952 4.81952 2.57780019722243 2.202422 2.202422 1.7025405950425976 12.19115 12.19115 1.8061628511847745 6.6423;2.99674 3.4063;0.998544 13.4683;10.914 0 0 Exp 4,1(0.5);Hill,1(0.5) 1.7465382082876029 3.520103096961975 1.5423688888549805 1.9777342081069946 0.30784976953654536 1.7600515484809875 1.2468712000000006 8.392168799999999 -0.15717888000000002 4.56202288 9.687936 14.694364 UP 1.0 0.0 0.0 GO:0007265 7 Ras protein signal transduction 42 44 2 2 1 1 1 1 51 43 2452 0.7739 0.59966 0.59966 2.27 363140 rassf1 RASSF1_32475 756.581 756.581 756.581 756.581 437.5 437.5 437.5 437.5 940.187 940.187 940.187 940.187 756.581 437.5 940.187 1 0 1 363140 RASSF1_32475 756.581 756.581 437.5 437.5 940.187 940.187 756.581 437.5 940.187 0 0 Poly 2,1(1) 2.1946890354156494 2.1946890354156494 2.1946890354156494 2.1946890354156494 0.0 2.1946890354156494 756.581 756.581 437.5 437.5 940.187 940.187 UP 1.0 0.0 0.0 GO:0010648 6 negative regulation of cell communication 320 334 16 15 9 10 7 7 45 327 2168 0.62839 0.53299 0.83768 2.1 308843;360918;83619;59107;24484;24424;24330 tsku;pf4;nfe2l2;ltbp1;igfbp3;gstm2;egr1 TSKU_10094;PF4_32963;NFE2L2_9301;LTBP1_33264;IGFBP3_8881;GSTM2_8759;EGR1_8533 178.23227 8.26335 3.28268 367.34012710917347 248.90462537255272 440.79489670128345 92.00198671428572 3.4063 0.808077 187.34772897137006 125.16794759605312 224.809075912902 818.4552571428572 45.9052 13.1174 1878.641181736791 1216.617119316623 2257.224485223798 6.12626;179.631;6.6423;998.777;44.9033;3.28268;8.26335 1.46625;110.795;3.4063;507.146;18.8755;0.808077;1.51678 41.3339;426.677;13.4683;5065.92;122.765;13.1174;45.9052 3 4 3 360918;83619;24424 PF4_32963;NFE2L2_9301;GSTM2_8759 63.18532666666667 6.6423 100.85890089712525 38.336459 3.4063 62.76438332028718 151.08756666666667 13.4683 238.66751476990606 179.631;6.6423;3.28268 110.795;3.4063;0.808077 426.677;13.4683;13.1174 4 308843;59107;24484;24330 TSKU_10094;LTBP1_33264;IGFBP3_8881;EGR1_8533 264.51747750000004 26.583325000000002 489.8297773998801 132.2511325 10.19614 250.0642265077452 1318.981025 84.3351 2498.2386257161966 6.12626;998.777;44.9033;8.26335 1.46625;507.146;18.8755;1.51678 41.3339;5065.92;122.765;45.9052 0 Exp 2,1(0.15);Exp 4,2(0.29);Hill,3(0.43);Poly 2,1(0.15) 2.0764048685129586 16.06037950515747 1.5423688888549805 5.289852619171143 1.3485905807016385 1.7059084177017212 -93.89710441360413 450.36164441360415 -46.787153159987525 230.79112658855897 -573.2616063451558 2210.1721206308703 CONFLICT 0.42857142857142855 0.5714285714285714 0.0 GO:0062197 5 cellular response to chemical stress 112 118 9 9 6 6 4 4 48 114 2381 0.90989 0.21875 0.30147 3.39 24314;83619;116686;24330 nqo1;nfe2l2;gsr;egr1 NQO1_33055;NFE2L2_9301;GSR_8755;EGR1_8533 28.412887500000004 16.187525 6.6423 31.806038654590292 34.217118600682596 35.00005433260078 19.65622 9.910699999999999 1.51678 25.946464546605704 24.236191357061593 28.67915163273257 50.736475 41.4743 13.4683 39.63400995268037 59.37620778482041 41.95613677159318 24.1117;6.6423;74.6342;8.26335 16.4151;3.4063;57.2867;1.51678 37.0434;13.4683;106.529;45.9052 3 1 3 24314;83619;116686 NQO1_33055;NFE2L2_9301;GSR_8755 35.129400000000004 24.1117 35.30958653637848 25.702700000000004 16.4151 28.115280744819174 52.3469 37.0434 48.38100149139123 24.1117;6.6423;74.6342 16.4151;3.4063;57.2867 37.0434;13.4683;106.529 1 24330 EGR1_8533 8.26335 8.26335 1.51678 1.51678 45.9052 45.9052 8.26335 1.51678 45.9052 0 Exp 4,2(0.5);Hill,1(0.25);Poly 2,1(0.25) 2.956207384526941 13.566885113716125 1.5423688888549805 5.289852619171143 1.913170828802681 3.367331802845001 -2.7570303814984847 59.58280538149849 -5.7713152556735885 45.083755255673594 11.895145246373232 89.57780475362676 UP 0.75 0.25 0.0 GO:0008284 6 positive regulation of cell population proliferation 272 293 8 7 6 4 3 3 49 290 2205 0.13417 0.94924 0.26984 1.02 25587;24330;58919 id2;egr1;ccnd1 ID2_8861;EGR1_8533;CCND1_8224 174.6643633333333 8.26335 2.99674 292.7878696573118 251.2216817863977 309.67054410803223 110.84644133333335 1.51678 0.998544 189.81351060830207 160.1571091079052 201.14464190901182 353.12639999999993 45.9052 10.914 562.6980510238861 502.9694325334903 591.7434973926917 2.99674;8.26335;512.733 0.998544;1.51678;330.024 10.914;45.9052;1002.56 1 2 1 25587 ID2_8861 2.99674 2.99674 0.998544 0.998544 10.914 10.914 2.99674 0.998544 10.914 2 24330;58919 EGR1_8533;CCND1_8224 260.49817499999995 260.49817499999995 356.71391041780424 165.77039 165.77039 232.28968293074104 524.2325999999999 524.2325999999999 676.4570963346604 8.26335;512.733 1.51678;330.024 45.9052;1002.56 0 Exp 2,1(0.34);Hill,2(0.67) 2.5341032828656225 8.823056101799011 1.555469274520874 5.289852619171143 2.0450776272083133 1.9777342081069946 -156.65630117639455 505.9850278430612 -103.94776629990761 325.6406489665743 -283.6263876129922 989.8791876129922 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0010817 4 regulation of hormone levels 159 176 16 15 8 14 7 7 45 169 2326 0.97582 0.063635 0.086858 3.98 299270;29200;24484;24330;499353;24296;24188 serpina6;inhba;igfbp3;egr1;cyp2c24;cyp1a1;aldh1a1 SERPINA6_32325;INHBA_33300;IGFBP3_8881;EGR1_8533;CYP2C24_32875;CYP1A1_8415;ALDH1A1_8022 160.36185 88.5069 8.26335 256.88669970777806 201.27270080570156 288.01217861904325 102.83242571428572 65.9487 1.51678 162.60304665736317 128.68094355113246 181.91464102933784 356.80234285714283 133.645 40.8362 623.8700372692559 453.7255911221691 704.0898060258281 15.8474;130.168;44.9033;8.26335;733.935;100.909;88.5069 7.7531;89.164;18.8755;1.51678;463.206;73.3629;65.9487 40.8362;231.33;122.765;45.9052;1763.75;159.385;133.645 2 5 2 24296;24188 CYP1A1_8415;ALDH1A1_8022 94.70795000000001 94.70795000000001 8.769609010953614 69.6558 69.6558 5.24263109707331 146.515 146.515 18.200928547741807 100.909;88.5069 73.3629;65.9487 159.385;133.645 5 299270;29200;24484;24330;499353 SERPINA6_32325;INHBA_33300;IGFBP3_8881;EGR1_8533;CYP2C24_32875 186.62340999999998 44.9033 309.7573792663106 116.10307600000002 18.8755 197.18588421215622 440.91728 122.765 743.4940349843918 15.8474;130.168;44.9033;8.26335;733.935 7.7531;89.164;18.8755;1.51678;463.206 40.8362;231.33;122.765;45.9052;1763.75 0 Exp 4,2(0.29);Hill,1(0.15);Linear,1(0.15);Poly 2,3(0.43) 2.182832418930156 16.80345916748047 1.6357452869415283 5.289852619171143 1.3367822460679275 1.8130581378936768 -29.942480313134723 350.66618031313476 -17.62559697122262 223.29044839979406 -105.36704847379082 818.9717341880764 DOWN 0.2857142857142857 0.7142857142857143 0.0 GO:0001822 5 kidney development 48 53 5 5 5 4 4 4 48 49 2446 0.99601 0.021642 0.021642 7.55 24522;25587;24330;24188 zfp354a;id2;egr1;aldh1a1 ZFP354A_10203;ID2_8861;EGR1_8533;ALDH1A1_8022 25.75853 5.76524 2.99674 41.90227288526403 30.49314078977876 44.48758023131364 17.545973500000002 1.618325 0.998544 32.269913500268466 21.221519218433 34.252905179882866 49.283100000000005 28.4096 6.6682 58.925257507116584 55.39373633465365 62.46761032099873 1.5 5.76524 3.26713;2.99674;8.26335;88.5069 1.71987;0.998544;1.51678;65.9487 6.6682;10.914;45.9052;133.645 2 2 2 25587;24188 ID2_8861;ALDH1A1_8022 45.75182 45.75182 60.46481399634667 33.473622 33.473622 45.92669574672413 72.2795 72.2795 86.78392236180619 2.99674;88.5069 0.998544;65.9487 10.914;133.645 2 24522;24330 ZFP354A_10203;EGR1_8533 5.76524 5.76524 3.5328610422998517 1.618325 1.618325 0.14360631619117753 26.2867 26.2867 27.74474877341656 3.26713;8.26335 1.71987;1.51678 6.6682;45.9052 0 Exp 4,1(0.25);Hill,2(0.5);Poly 2,1(0.25) 3.713764931961438 16.56228530406952 1.9777342081069946 6.495501518249512 2.1090039745031994 4.044524788856506 -15.305697427558755 66.82275742755876 -14.078541730263098 49.170488730263095 -8.463652356974258 107.02985235697426 CONFLICT 0.5 0.5 0.0 GO:0046456 6 icosanoid biosynthetic process 13 16 2 2 2 1 1 1 51 15 2480 0.95913 0.28181 0.28181 6.25 29277 cyp2c11 CYP2C11_32593 129.934 129.934 129.934 129.934 45.3106 45.3106 45.3106 45.3106 355.143 355.143 355.143 355.143 0.0 129.934 129.934 45.3106 355.143 0 1 0 1 29277 CYP2C11_32593 129.934 129.934 45.3106 45.3106 355.143 355.143 129.934 45.3106 355.143 0 Exp 4,1(1) 1.628912329673767 1.628912329673767 1.628912329673767 1.628912329673767 0.0 1.628912329673767 129.934 129.934 45.3106 45.3106 355.143 355.143 DOWN 0.0 1.0 0.0 GO:0045214 7 sarcomere organization 18 18 1 1 1 1 1 1 51 17 2478 0.94922 0.31103 0.31103 5.56 29276 csrp1 CSRP1_8396 373.299 373.299 373.299 373.299 263.875 263.875 263.875 263.875 603.145 603.145 603.145 603.145 0.0 373.299 373.299 263.875 603.145 0 1 0 1 29276 CSRP1_8396 373.299 373.299 263.875 263.875 603.145 603.145 373.299 263.875 603.145 0 Exp 2,1(1) 1.8113902807235718 1.8113902807235718 1.8113902807235718 1.8113902807235718 0.0 1.8113902807235718 373.299 373.299 263.875 263.875 603.145 603.145 DOWN 0.0 1.0 0.0 GO:0043207 4 response to external biotic stimulus 357 390 21 19 10 14 8 8 44 382 2113 0.59889 0.55437 1.0 2.05 286954;360918;24614;24539;24484;24296;54232;140668 ugt2b1;pf4;orm1;lpl;igfbp3;cyp1a1;car3;abcc3 UGT2B10_33303,UGT2B1_33224;PF4_32963;ORM1_9400;LPL_32544;IGFBP3_8881;CYP1A1_8415;CAR3_8196;ABCC3_7941 164.8823875 71.7371 25.4966 248.83525426237586 189.87840297365776 283.69552217629274 92.4719625 32.55545 11.3392 146.1703370226369 106.43891228761294 166.34325499032784 429.21046875 141.075 63.97775 718.2571286920169 506.710025914328 819.4768163397774 25.4966;179.631;56.9823;769.435;44.9033;100.909;55.21;86.4919 11.3392;110.795;16.0812;444.211;18.8755;73.3629;24.6611;40.4498 63.97775;426.677;262.985;2183.16;122.765;159.385;106.714;108.02 6 3 5 286954;360918;24614;24296;140668 UGT2B10_33303,UGT2B1_33224;PF4_32963;ORM1_9400;CYP1A1_8415;ABCC3_7941 89.90216000000001 86.4919 57.91338029577447 50.40562 40.4498 41.76536619499462 204.20895000000002 159.385 144.804132687529 25.4966;179.631;56.9823;100.909;86.4919 11.3392;110.795;16.0812;73.3629;40.4498 63.97775;426.677;262.985;159.385;108.02 3 24539;24484;54232 LPL_32544;IGFBP3_8881;CAR3_8196 289.8494333333333 55.21 415.36525352087807 162.58253333333334 24.6611 243.9145613111348 804.2129999999999 122.765 1194.2300993765814 769.435;44.9033;55.21 444.211;18.8755;24.6611 2183.16;122.765;106.714 0 Exp 2,1(0.12);Exp 4,4(0.45);Exp 5,2(0.23);Poly 2,2(0.23) 1.9573832746680917 18.220760822296143 1.5846891403198242 3.368933916091919 0.6157919068723928 1.7026138305664062 -7.551646273460619 337.3164212734606 -8.818913286688996 193.762838286689 -68.51632785702981 926.9372653570299 UP 0.625 0.375 0.0 GO:0009891 6 positive regulation of biosynthetic process 418 451 24 22 10 17 9 9 43 442 2053 0.55764 0.58825 1.0 2.0 360918;316351;83619;59107;29200;494344;25587;24330;25695 pf4;npas2;nfe2l2;ltbp1;inhba;ier2;id2;egr1;cebpd PF4_32963;NPAS2_9350;NFE2L2_9301;LTBP1_33264;INHBA_33300;IER2_32643;ID2_8861;EGR1_8533;CEBPD_8283 223.34852666666666 130.168 2.99674 337.5413917795354 281.1813470179916 396.59880642731923 127.53960822222221 56.7249 0.998544 185.60679866194607 151.34171526068644 211.0901108309254 789.995388888889 231.33 10.914 1633.4769343124183 1138.72360191655 2012.458425908927 179.631;134.458;6.6423;998.777;130.168;543.54;2.99674;8.26335;5.66035 110.795;56.7249;3.4063;507.146;89.164;375.947;0.998544;1.51678;2.15795 426.677;320.448;13.4683;5065.92;231.33;978.946;10.914;45.9052;16.35 3 6 3 360918;83619;25587 PF4_32963;NFE2L2_9301;ID2_8861 63.09001333333333 6.6423 100.94391366921799 38.399948 3.4063 62.70751141451009 150.3531 13.4683 239.3069250889535 179.631;6.6423;2.99674 110.795;3.4063;0.998544 426.677;13.4683;10.914 6 316351;59107;29200;494344;24330;25695 NPAS2_9350;LTBP1_33264;INHBA_33300;IER2_32643;EGR1_8533;CEBPD_8283 303.4777833333333 132.313 393.8328635273759 172.10943833333332 72.94445 215.3964484806043 1109.8165333333334 275.889 1969.2790249655804 134.458;998.777;130.168;543.54;8.26335;5.66035 56.7249;507.146;89.164;375.947;1.51678;2.15795 320.448;5065.92;231.33;978.946;45.9052;16.35 0 Exp 2,1(0.12);Exp 4,2(0.23);Hill,3(0.34);Linear,1(0.12);Poly 2,2(0.23) 1.9334169604529485 18.98572325706482 1.5423688888549805 5.289852619171143 1.2031134777256978 1.6427439451217651 2.821484037370169 443.8755692959631 6.276499763084146 248.80271668136032 -277.20954152855757 1857.2003193063351 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0010628 7 positive regulation of gene expression 455 488 23 21 12 15 10 10 42 478 2017 0.58898 0.55161 1.0 2.05 360918;24614;316351;83619;24539;29200;494344;25587;24330;25695 pf4;orm1;npas2;nfe2l2;lpl;inhba;ier2;id2;egr1;cebpd PF4_32963;ORM1_9400;NPAS2_9350;NFE2L2_9301;LPL_32544;INHBA_33300;IER2_32643;ID2_8861;EGR1_8533;CEBPD_8283 183.777704 93.57515000000001 2.99674 262.55451703248144 222.9124774697641 303.6283741655783 110.1002674 36.40305 0.998544 163.6936495233689 127.11236269688257 184.70370118524446 449.01835 247.15750000000003 10.914 676.4645061473583 592.7941673871393 822.4274658185261 179.631;56.9823;134.458;6.6423;769.435;130.168;543.54;2.99674;8.26335;5.66035 110.795;16.0812;56.7249;3.4063;444.211;89.164;375.947;0.998544;1.51678;2.15795 426.677;262.985;320.448;13.4683;2183.16;231.33;978.946;10.914;45.9052;16.35 4 6 4 360918;24614;83619;25587 PF4_32963;ORM1_9400;NFE2L2_9301;ID2_8861 61.563085 31.8123 82.47691704418212 32.820261 9.743749999999999 52.402477230939674 178.511075 138.22665 203.347049371485 179.631;56.9823;6.6423;2.99674 110.795;16.0812;3.4063;0.998544 426.677;262.985;13.4683;10.914 6 316351;24539;29200;494344;24330;25695 NPAS2_9350;LPL_32544;INHBA_33300;IER2_32643;EGR1_8533;CEBPD_8283 265.2541166666667 132.313 316.3638591485011 161.62027166666667 72.94445 196.52367622967878 629.3565333333332 275.889 837.4437389712735 134.458;769.435;130.168;543.54;8.26335;5.66035 56.7249;444.211;89.164;375.947;1.51678;2.15795 320.448;2183.16;231.33;978.946;45.9052;16.35 0 Exp 2,1(0.1);Exp 4,3(0.3);Hill,3(0.3);Linear,1(0.1);Poly 2,2(0.2) 1.9007493768214687 20.617893934249878 1.5423688888549805 5.289852619171143 1.1445741397834976 1.662985384464264 21.044728377529566 346.5106796224704 8.641892284160377 211.55864251583964 29.741305245421188 868.2953947545786 DOWN 0.4 0.6 0.0 GO:0046223 6 aflatoxin catabolic process 2 3 2 2 2 2 2 2 50 1 2494 0.99999 0.0012108 0.0012108 66.67 83619;26760 nfe2l2;akr7a3 NFE2L2_9301;AKR7A3_8015 13.2462 13.2462 6.6423 9.339324944555681 14.965965625 9.017083941615311 8.10165 8.10165 3.4063 6.640227650088516 9.324397395833333 6.4111154144162485 22.91135 22.91135 13.4683 13.354489380167255 25.370477604166663 12.893710461222987 0.0 6.6423 0.0 6.6423 6.6423;19.8501 3.4063;12.797 13.4683;32.3544 2 0 2 83619;26760 NFE2L2_9301;AKR7A3_8015 13.2462 13.2462 9.339324944555681 8.10165 8.10165 6.640227650088516 22.91135 22.91135 13.354489380167255 6.6423;19.8501 3.4063;12.797 13.4683;32.3544 0 0 Exp 4,2(1) 2.521264970971509 5.663806438446045 1.5423688888549805 4.1214375495910645 1.8236769391521923 2.8319032192230225 0.30255599999999916 26.189844000000004 -1.101236 17.304536 4.402971999999998 41.419728 UP 1.0 0.0 0.0 GO:1901377 6 organic heteropentacyclic compound catabolic process 2 3 2 2 2 2 2 2 50 1 2494 0.99999 0.0012108 0.0012108 66.67 83619;26760 nfe2l2;akr7a3 NFE2L2_9301;AKR7A3_8015 13.2462 13.2462 6.6423 9.339324944555681 14.965965625 9.017083941615311 8.10165 8.10165 3.4063 6.640227650088516 9.324397395833333 6.4111154144162485 22.91135 22.91135 13.4683 13.354489380167255 25.370477604166663 12.893710461222987 0.0 6.6423 0.0 6.6423 6.6423;19.8501 3.4063;12.797 13.4683;32.3544 2 0 2 83619;26760 NFE2L2_9301;AKR7A3_8015 13.2462 13.2462 9.339324944555681 8.10165 8.10165 6.640227650088516 22.91135 22.91135 13.354489380167255 6.6423;19.8501 3.4063;12.797 13.4683;32.3544 0 0 Exp 4,2(1) 2.521264970971509 5.663806438446045 1.5423688888549805 4.1214375495910645 1.8236769391521923 2.8319032192230225 0.30255599999999916 26.189844000000004 -1.101236 17.304536 4.402971999999998 41.419728 UP 1.0 0.0 0.0 GO:0098869 4 cellular oxidant detoxification 38 46 4 4 3 3 3 3 49 43 2452 0.98661 0.065869 0.065869 6.52 24314;24424;116686 nqo1;gstm2;gsr NQO1_33055;GSTM2_8759;GSR_8755 34.009526666666666 24.1117 3.28268 36.69107631455003 51.828278406323825 34.079892777059925 24.836625666666666 16.4151 0.808077 29.16590963624787 38.95615033445394 27.318233124657205 52.22993333333333 37.0434 13.1174 48.52220985954096 75.61479062329639 45.927681278119394 1.5 49.37295 24.1117;3.28268;74.6342 16.4151;0.808077;57.2867 37.0434;13.1174;106.529 3 0 3 24314;24424;116686 NQO1_33055;GSTM2_8759;GSR_8755 34.009526666666666 24.1117 36.69107631455003 24.836625666666666 16.4151 29.16590963624787 52.22993333333333 37.0434 48.52220985954096 24.1117;3.28268;74.6342 16.4151;0.808077;57.2867 37.0434;13.1174;106.529 0 0 Exp 4,1(0.34);Hill,1(0.34);Poly 2,1(0.34) 2.518186112344177 8.440572023391724 1.7059084177017212 4.773829460144043 1.7024526077264759 1.9608341455459595 -7.510334795975943 75.5293881293093 -8.167708061443431 57.84095939477676 -2.6781160778663775 107.13798274453305 UP 1.0 0.0 0.0 GO:0032369 6 negative regulation of lipid transport 13 14 3 2 2 2 2 2 50 12 2483 0.99751 0.031809 0.031809 14.29 24484;114628 igfbp3;abcg5 IGFBP3_8881;ABCG5_7947 202.93565 202.93565 44.9033 223.49149266369182 189.12950683251577 222.63698730157768 146.26125 146.26125 18.8755 180.15065530306848 135.13247856809156 179.46186084780706 325.6765 325.6765 122.765 286.96019526146824 307.9495901658491 285.86302139305064 0.0 44.9033 0.5 202.93565 44.9033;360.968 18.8755;273.647 122.765;528.588 0 2 0 2 24484;114628 IGFBP3_8881;ABCG5_7947 202.93565 202.93565 223.49149266369182 146.26125 146.26125 180.15065530306848 325.6765 325.6765 286.96019526146824 44.9033;360.968 18.8755;273.647 122.765;528.588 0 Exp 4,1(0.5);Linear,1(0.5) 1.8870509916407023 3.806691884994507 1.6548216342926025 2.1518702507019043 0.35146644724240833 1.9033459424972534 -106.80775599999998 512.679056 -103.41481999999999 395.93732 -72.03003999999993 723.3830399999999 DOWN 0.0 1.0 0.0 GO:0050789 3 regulation of biological process 1644 1779 78 74 42 58 34 34 18 1745 750 0.28478 0.80679 0.54139 1.91 24522;308843;246273;170698;299270;363140;360918;24614;338475;24314;316351;83619;25333;59107;24539;29200;24484;494344;25587;24424;116686;297417;289388;246248;24330;24296;289185;25695;58919;117517;25612;64392;24188;114628 zfp354a;tsku;trib3;slco1a2;serpina6;rassf1;pf4;orm1;nrep;nqo1;npas2;nfe2l2;mgp;ltbp1;lpl;inhba;igfbp3;ier2;id2;gstm2;gsr;gfpt1;g0s2;fmo5;egr1;cyp1a1;creg1;cebpd;ccnd1;c7;asns;aldh1l1;aldh1a1;abcg5 ZFP354A_10203;TSKU_10094;TRIB3_10079;SLCO1A2_9886;SERPINA6_32325;RASSF1_32475;PF4_32963;ORM1_9400;NREP_9364;NQO1_33055;NPAS2_9350;NFE2L2_9301;MGP_33209;LTBP1_33264;LPL_32544;INHBA_33300;IGFBP3_8881;IER2_32643;ID2_8861;GSTM2_8759;GSR_8755;GFPT1_8705;G0S2_32729;FMO5_33281;EGR1_8533;CYP1A1_8415;CREG1_8380;CEBPD_8283;CCND1_8224;C7_8179;ASNS_8091;ALDH1L1_32662;ALDH1A1_8022;ABCG5_7947 204.81376911764704 81.80369999999999 2.99674 289.6330196988634 237.41205942829663 300.90891425263345 121.14648414705883 55.15975 0.808077 168.2870014751873 139.2697175377978 173.65730356776012 594.8433529411765 153.403 6.6682 1132.4663486696186 638.0971257360403 1127.3186674971116 3.26713;6.12626;16.8949;440.994;15.8474;756.581;179.631;56.9823;112.624;24.1117;134.458;6.6423;75.1005;998.777;769.435;130.168;44.9033;543.54;2.99674;3.28268;74.6342;981.5;3.45084;57.4978;8.26335;100.909;94.3216;5.66035;512.733;13.8429;154.987;184.03;88.5069;360.968 1.71987;1.46625;6.46469;299.351;7.7531;437.5;110.795;16.0812;79.4619;16.4151;56.7249;3.4063;13.9312;507.146;444.211;89.164;18.8755;375.947;0.998544;0.808077;57.2867;554.87;1.07374;31.5489;1.51678;73.3629;69.2457;2.15795;330.024;5.32886;53.5946;111.154;65.9487;273.647 6.6682;41.3339;58.9909;772.521;40.8362;940.187;426.677;262.985;192.339;37.0434;320.448;13.4683;346.231;5065.92;2183.16;231.33;122.765;978.946;10.914;13.1174;106.529;4240.48;14.3222;109.026;45.9052;159.385;147.421;16.35;1002.56;41.8963;462.615;1150.07;133.645;528.588 17 17 17 246273;363140;360918;24614;24314;83619;25587;24424;116686;297417;289388;246248;24296;289185;25612;64392;24188 TRIB3_10079;RASSF1_32475;PF4_32963;ORM1_9400;NQO1_33055;NFE2L2_9301;ID2_8861;GSTM2_8759;GSR_8755;GFPT1_8705;G0S2_32729;FMO5_33281;CYP1A1_8415;CREG1_8380;ASNS_8091;ALDH1L1_32662;ALDH1A1_8022 163.93882117647058 74.6342 274.88633310800276 94.73847947058823 53.5946 156.8431364449341 487.46330588235287 133.645 1021.8770910385048 16.8949;756.581;179.631;56.9823;24.1117;6.6423;2.99674;3.28268;74.6342;981.5;3.45084;57.4978;100.909;94.3216;154.987;184.03;88.5069 6.46469;437.5;110.795;16.0812;16.4151;3.4063;0.998544;0.808077;57.2867;554.87;1.07374;31.5489;73.3629;69.2457;53.5946;111.154;65.9487 58.9909;940.187;426.677;262.985;37.0434;13.4683;10.914;13.1174;106.529;4240.48;14.3222;109.026;159.385;147.421;462.615;1150.07;133.645 17 24522;308843;170698;299270;338475;316351;25333;59107;24539;29200;24484;494344;24330;25695;58919;117517;114628 ZFP354A_10203;TSKU_10094;SLCO1A2_9886;SERPINA6_32325;NREP_9364;NPAS2_9350;MGP_33209;LTBP1_33264;LPL_32544;INHBA_33300;IGFBP3_8881;IER2_32643;EGR1_8533;CEBPD_8283;CCND1_8224;C7_8179;ABCG5_7947 245.6887170588235 112.624 306.43867827333116 147.5544888235294 56.7249 179.8036545773486 702.2234 231.33 1255.539731012999 3.26713;6.12626;440.994;15.8474;112.624;134.458;75.1005;998.777;769.435;130.168;44.9033;543.54;8.26335;5.66035;512.733;13.8429;360.968 1.71987;1.46625;299.351;7.7531;79.4619;56.7249;13.9312;507.146;444.211;89.164;18.8755;375.947;1.51678;2.15795;330.024;5.32886;273.647 6.6682;41.3339;772.521;40.8362;192.339;320.448;346.231;5065.92;2183.16;231.33;122.765;978.946;45.9052;16.35;1002.56;41.8963;528.588 0 Exp 2,4(0.12);Exp 4,10(0.3);Exp 5,1(0.03);Hill,7(0.21);Linear,3(0.09);Poly 2,9(0.27) 2.0580894205704205 75.39677035808563 1.5232417583465576 6.495501518249512 1.1116242660131617 1.8453741073608398 107.45732906338843 302.1702091719057 64.57895815135379 177.7140101427639 214.17925496522486 975.5074509171282 CONFLICT 0.5 0.5 0.0 GO:0071385 8 cellular response to glucocorticoid stimulus 47 51 7 7 3 5 3 3 49 48 2447 0.98097 0.084235 0.084235 5.88 286954;24614;25315 ugt2b1;orm1;ephx1 UGT2B10_33303,UGT2B1_33224;ORM1_9400;EPHX1_8567 35.78576666666667 25.4966 24.8784 18.359338545365212 44.62002116901548 18.917808713934217 14.302366666666666 15.4867 11.3392 2.5833360376329906 14.685123495824945 2.5691450005521794 122.78075000000001 63.97775 41.3795 121.94504505847091 182.7954970213538 122.95118824684862 1.5 41.239450000000005 25.4966;56.9823;24.8784 11.3392;16.0812;15.4867 63.97775;262.985;41.3795 4 0 3 286954;24614;25315 UGT2B10_33303,UGT2B1_33224;ORM1_9400;EPHX1_8567 35.78576666666667 25.4966 18.359338545365212 14.302366666666666 15.4867 2.5833360376329906 122.78075000000001 63.97775 121.94504505847091 25.4966;56.9823;24.8784 11.3392;16.0812;15.4867 63.97775;262.985;41.3795 0 0 Exp 4,4(1) 1.8645354745543752 7.622990250587463 1.5846891403198242 2.6370131969451904 0.4905679285739102 1.7006439566612244 15.010219326098895 56.561314007234444 11.379046743466715 17.22568658986662 -15.213058998064469 260.7745589980645 UP 1.0 0.0 0.0 GO:0042981 7 regulation of apoptotic process 428 455 19 19 11 14 9 9 43 446 2049 0.54567 0.59981 1.0 1.98 360918;24314;83619;29200;24484;289388;24330;25612;24188 pf4;nqo1;nfe2l2;inhba;igfbp3;g0s2;egr1;asns;aldh1a1 PF4_32963;NQO1_33055;NFE2L2_9301;INHBA_33300;IGFBP3_8881;G0S2_32729;EGR1_8533;ASNS_8091;ALDH1A1_8022 71.18493222222222 44.9033 3.45084 69.08489935331994 60.05587829262783 54.253148711525895 40.08774666666667 18.8755 1.07374 41.2688027353266 33.69940091763842 33.48331625374177 165.30790000000002 122.765 13.4683 173.36284415592053 135.97097768585706 132.87639464615881 179.631;24.1117;6.6423;130.168;44.9033;3.45084;8.26335;154.987;88.5069 110.795;16.4151;3.4063;89.164;18.8755;1.07374;1.51678;53.5946;65.9487 426.677;37.0434;13.4683;231.33;122.765;14.3222;45.9052;462.615;133.645 6 3 6 360918;24314;83619;289388;25612;24188 PF4_32963;NQO1_33055;NFE2L2_9301;G0S2_32729;ASNS_8091;ALDH1A1_8022 76.22162333333334 56.3093 77.33139727055801 41.872240000000005 35.00485 43.03405306366575 181.29515 85.3442 209.0349406674181 179.631;24.1117;6.6423;3.45084;154.987;88.5069 110.795;16.4151;3.4063;1.07374;53.5946;65.9487 426.677;37.0434;13.4683;14.3222;462.615;133.645 3 29200;24484;24330 INHBA_33300;IGFBP3_8881;EGR1_8533 61.11155 44.9033 62.54771337908766 36.51876 18.8755 46.41090670308866 133.3334 122.765 93.16306898487194 130.168;44.9033;8.26335 89.164;18.8755;1.51678 231.33;122.765;45.9052 0 Exp 4,5(0.56);Hill,1(0.12);Poly 2,3(0.34) 2.4348728435713776 24.270328998565674 1.5423688888549805 5.289852619171143 1.399864864681082 2.0805697441101074 26.049464644719883 116.32039979972458 13.125462212919953 67.05003112041337 52.044175151465254 278.5716248485348 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0051241 5 negative regulation of multicellular organismal process 326 344 17 16 9 12 7 7 45 337 2158 0.59545 0.56633 1.0 2.03 360918;24614;83619;29200;25587;24188;114628 pf4;orm1;nfe2l2;inhba;id2;aldh1a1;abcg5 PF4_32963;ORM1_9400;NFE2L2_9301;INHBA_33300;ID2_8861;ALDH1A1_8022;ABCG5_7947 117.98503428571429 88.5069 2.99674 124.632244130488 137.20800026846456 141.54061289118752 80.00582057142857 65.9487 0.998544 95.67509972800879 94.27452343207538 113.09733117930115 229.6581857142857 231.33 10.914 197.10172325682007 261.75012827419994 191.50043594597236 179.631;56.9823;6.6423;130.168;2.99674;88.5069;360.968 110.795;16.0812;3.4063;89.164;0.998544;65.9487;273.647 426.677;262.985;13.4683;231.33;10.914;133.645;528.588 5 2 5 360918;24614;83619;25587;24188 PF4_32963;ORM1_9400;NFE2L2_9301;ID2_8861;ALDH1A1_8022 66.951848 56.9823 72.4363528705409 39.4459488 16.0812 47.73901349074683 169.53786 133.645 177.243081115309 179.631;56.9823;6.6423;2.99674;88.5069 110.795;16.0812;3.4063;0.998544;65.9487 426.677;262.985;13.4683;10.914;133.645 2 29200;114628 INHBA_33300;ABCG5_7947 245.568 245.568 163.20024509785515 181.4055 181.4055 130.44918031363784 379.959 379.959 210.1931475619507 130.168;360.968 89.164;273.647 231.33;528.588 0 Exp 4,2(0.29);Hill,1(0.15);Linear,1(0.15);Poly 2,3(0.43) 1.8975357344042307 13.551396250724792 1.5423688888549805 2.79919695854187 0.441168154595131 1.8597915172576904 25.656175759149306 210.3138928122793 9.128714819776462 150.88292632308068 83.6431857527356 375.67318567583584 UP 0.7142857142857143 0.2857142857142857 0.0 GO:0070301 6 cellular response to hydrogen peroxide 41 45 2 2 2 2 2 2 50 43 2452 0.93755 0.23371 0.23371 4.44 24314;83619 nqo1;nfe2l2 NQO1_33055;NFE2L2_9301 15.376999999999999 15.376999999999999 6.6423 12.352731203260275 15.379509971264369 12.352730693255177 9.910699999999999 9.910699999999999 3.4063 9.198610695099562 9.91256908045977 9.198610315318096 25.25585 25.25585 13.4683 16.670113077150972 25.259237227011496 16.67011238889487 24.1117;6.6423 16.4151;3.4063 37.0434;13.4683 2 0 2 24314;83619 NQO1_33055;NFE2L2_9301 15.376999999999999 15.376999999999999 12.352731203260275 9.910699999999999 9.910699999999999 9.198610695099562 25.25585 25.25585 16.670113077150972 24.1117;6.6423 16.4151;3.4063 37.0434;13.4683 0 0 Exp 4,2(1) 2.713485957219152 6.316198348999023 1.5423688888549805 4.773829460144043 2.284987683095451 3.1580991744995117 -1.7430120000000002 32.497012 -2.8379239999999992 22.659323999999998 2.1522520000000043 48.35944799999999 UP 1.0 0.0 0.0 GO:0002009 5 morphogenesis of an epithelium 84 87 3 3 3 2 2 2 50 85 2410 0.7388 0.53645 0.69752 2.3 25333;24188 mgp;aldh1a1 MGP_33209;ALDH1A1_8022 81.80369999999999 81.80369999999999 75.1005 9.479756351299452 80.56009647111856 9.315185505716197 39.93995 39.93995 13.9312 36.78192699037123 35.11470634297122 36.14338390944609 239.938 239.938 133.645 150.32100218532344 259.657887500805 147.71139350744474 75.1005;88.5069 13.9312;65.9487 346.231;133.645 1 1 1 24188 ALDH1A1_8022 88.5069 88.5069 65.9487 65.9487 133.645 133.645 88.5069 65.9487 133.645 1 25333 MGP_33209 75.1005 75.1005 13.9312 13.9312 346.231 346.231 75.1005 13.9312 346.231 0 Hill,1(0.5);Poly 2,1(0.5) 2.377259327483394 4.818119525909424 2.0189225673675537 2.79919695854187 0.551737313185564 2.409059762954712 68.66542799999999 94.94197199999999 -11.037199999999991 90.91709999999998 31.60372000000001 448.27227999999997 CONFLICT 0.5 0.5 0.0 GO:0009416 5 response to light stimulus 83 88 6 4 4 4 3 3 49 85 2410 0.8973 0.2668 0.42446 3.41 25587;58919;25612 id2;ccnd1;asns ID2_8861;CCND1_8224;ASNS_8091 223.57224666666664 154.987 2.99674 261.6977564576023 334.9117030881576 261.5141979882641 128.20571466666667 53.5946 0.998544 176.74713999907848 204.00401843040646 181.62641718242685 492.0296666666666 462.615 10.914 496.47695242612554 695.1555142530353 474.5088945155639 2.99674;512.733;154.987 0.998544;330.024;53.5946 10.914;1002.56;462.615 2 1 2 25587;25612 ID2_8861;ASNS_8091 78.99186999999999 78.99186999999999 107.47334352030649 27.296572 27.296572 37.19102786126739 236.7645 236.7645 319.4008401687447 2.99674;154.987 0.998544;53.5946 10.914;462.615 1 58919 CCND1_8224 512.733 512.733 330.024 330.024 1002.56 1002.56 512.733 330.024 1002.56 0 Exp 2,1(0.34);Exp 4,1(0.34);Hill,1(0.34) 2.008584530285414 6.167356371879578 1.555469274520874 2.634152889251709 0.5435610207666105 1.9777342081069946 -72.56664280208423 519.7111361354175 -71.80250269298364 328.21393202631697 -69.78689350748385 1053.846226840817 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0065009 3 regulation of molecular function 643 686 24 22 12 14 8 8 44 678 1817 0.035871 0.98454 0.058974 1.17 246273;299270;24314;24484;25587;24424;24330;58919 trib3;serpina6;nqo1;igfbp3;id2;gstm2;egr1;ccnd1 TRIB3_10079;SERPINA6_32325;NQO1_33055;IGFBP3_8881;ID2_8861;GSTM2_8759;EGR1_8533;CCND1_8224 78.62913375 16.37115 2.99674 175.92900412511347 128.99535857101125 214.03062151604266 47.856973875 7.108895 0.808077 114.22103538629007 78.9561727288394 139.84660681889488 166.5165125 43.3707 10.914 339.59934614321804 269.37552506815524 409.80966735981656 16.8949;15.8474;24.1117;44.9033;2.99674;3.28268;8.26335;512.733 6.46469;7.7531;16.4151;18.8755;0.998544;0.808077;1.51678;330.024 58.9909;40.8362;37.0434;122.765;10.914;13.1174;45.9052;1002.56 4 4 4 246273;24314;25587;24424 TRIB3_10079;NQO1_33055;ID2_8861;GSTM2_8759 11.821505 10.08879 10.44950141792899 6.17160275 3.731617 7.315351013422271 30.016424999999998 25.080399999999997 22.652286610167344 16.8949;24.1117;2.99674;3.28268 6.46469;16.4151;0.998544;0.808077 58.9909;37.0434;10.914;13.1174 4 299270;24484;24330;58919 SERPINA6_32325;IGFBP3_8881;EGR1_8533;CCND1_8224 145.4367625 30.37535 245.37281235835593 89.542345 13.3143 160.4817851190931 303.0166 84.3351 467.8662351357276 15.8474;44.9033;8.26335;512.733 7.7531;18.8755;1.51678;330.024 40.8362;122.765;45.9052;1002.56 0 Exp 2,1(0.13);Exp 4,4(0.5);Hill,3(0.38) 2.3410821754183853 21.039884328842163 1.555469274520874 5.289852619171143 1.5049142720108586 1.8953961730003357 -43.28344623777855 200.54171373777854 -31.294165427278436 127.00811317727843 -68.81382803349936 401.8468530334993 CONFLICT 0.5 0.5 0.0 GO:0006974 5 cellular response to DNA damage stimulus 142 151 8 7 4 5 3 3 49 148 2347 0.62812 0.6047 1.0 1.99 363140;307126;58919 rassf1;mcm10;ccnd1 RASSF1_32475;MCM10_32579;CCND1_8224 494.30733333333336 512.733 213.608 271.9550488156698 509.7151275802752 283.25589866832945 296.9003333333333 330.024 123.177 159.75800465808697 303.64728526376143 165.13553313886052 870.2806666666667 940.187 668.095 177.85353703633012 866.0982998034075 174.40572497237605 756.581;213.608;512.733 437.5;123.177;330.024 940.187;668.095;1002.56 1 2 1 363140 RASSF1_32475 756.581 756.581 437.5 437.5 940.187 940.187 756.581 437.5 940.187 2 307126;58919 MCM10_32579;CCND1_8224 363.17049999999995 363.17049999999995 211.51331592242616 226.6005 226.6005 146.2629163680938 835.3275 835.3275 236.50246956955883 213.608;512.733 123.177;330.024 668.095;1002.56 0 Exp 2,1(0.34);Poly 2,2(0.67) 1.9294189137831135 5.854155540466309 1.555469274520874 2.1946890354156494 0.3458587921669631 2.103997230529785 186.561224876572 802.0534417900947 116.11713242402712 477.68353424263955 669.020443197532 1071.5408901358014 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0042149 6 cellular response to glucose starvation 22 22 4 4 2 3 2 2 50 20 2475 0.9906 0.072832 0.072832 9.09 83619;25612 nfe2l2;asns NFE2L2_9301;ASNS_8091 80.81465 80.81465 6.6423 104.89554332308404 72.88531191536748 104.29442077179483 28.50045 28.50045 3.4063 35.4884872662248 25.817779175946544 35.28511418352709 238.04165 238.04165 13.4683 317.5946773175599 214.03380857461022 315.77464458159346 0.5 80.81465 6.6423;154.987 3.4063;53.5946 13.4683;462.615 2 0 2 83619;25612 NFE2L2_9301;ASNS_8091 80.81465 80.81465 104.89554332308404 28.50045 28.50045 35.4884872662248 238.04165 238.04165 317.5946773175599 6.6423;154.987 3.4063;53.5946 13.4683;462.615 0 0 Exp 4,2(1) 2.015647653948798 4.1765217781066895 1.5423688888549805 2.634152889251709 0.772007870271503 2.0882608890533447 -64.56315599999996 226.19245599999996 -20.684084 77.684984 -202.12211599999995 678.205416 UP 1.0 0.0 0.0 GO:0010212 5 response to ionizing radiation 75 76 5 5 4 3 3 3 49 73 2422 0.9326 0.20116 0.20116 3.95 24330;58919;114628 egr1;ccnd1;abcg5 EGR1_8533;CCND1_8224;ABCG5_7947 293.98811666666666 360.968 8.26335 258.8187310093511 320.93394611955677 240.04748059081535 201.72925999999998 273.647 1.51678 175.66550427748413 222.22004880494717 162.54915381235847 525.6844 528.588 45.9052 478.33400962139416 563.8730179026023 450.1690087568519 8.26335;512.733;360.968 1.51678;330.024;273.647 45.9052;1002.56;528.588 0 3 0 3 24330;58919;114628 EGR1_8533;CCND1_8224;ABCG5_7947 293.98811666666666 360.968 258.8187310093511 201.72925999999998 273.647 175.66550427748413 525.6844 528.588 478.33400962139416 8.26335;512.733;360.968 1.51678;330.024;273.647 45.9052;1002.56;528.588 0 Exp 2,1(0.34);Hill,1(0.34);Linear,1(0.34) 2.606395778533291 8.997192144393921 1.555469274520874 5.289852619171143 2.006167425466397 2.1518702507019043 1.1071511883169478 586.8690821450164 2.9450286834038195 400.5134913165962 -15.601487666231378 1066.9702876662313 DOWN 0.0 1.0 0.0 GO:1903707 6 negative regulation of hemopoiesis 45 48 5 5 4 3 3 3 49 45 2450 0.9845 0.072969 0.072969 6.25 360918;83619;25587 pf4;nfe2l2;id2 PF4_32963;NFE2L2_9301;ID2_8861 63.09001333333333 6.6423 2.99674 100.94391366921799 32.48943700848111 77.47208367594557 38.399948 3.4063 0.998544 62.70751141451009 19.407302695451044 48.11894008757977 150.3531 13.4683 10.914 239.3069250889535 77.10101660755589 184.0020541950483 1.5 93.13665 179.631;6.6423;2.99674 110.795;3.4063;0.998544 426.677;13.4683;10.914 3 0 3 360918;83619;25587 PF4_32963;NFE2L2_9301;ID2_8861 63.09001333333333 6.6423 100.94391366921799 38.399948 3.4063 62.70751141451009 150.3531 13.4683 239.3069250889535 179.631;6.6423;2.99674 110.795;3.4063;0.998544 426.677;13.4683;10.914 0 0 Exp 4,1(0.34);Hill,1(0.34);Poly 2,1(0.34) 1.7835015104290102 5.3798946142196655 1.5423688888549805 1.9777342081069946 0.22517051485273246 1.8597915172576904 -51.13877829742228 177.31880496408894 -32.5602812469427 109.3601772469427 -120.44817853333592 421.1543785333359 UP 1.0 0.0 0.0 GO:0061418 9 regulation of transcription from RNA polymerase II promoter in response to hypoxia 6 7 2 2 2 2 2 2 50 5 2490 0.99973 0.0080418 0.0080418 28.57 83619;24330 nfe2l2;egr1 NFE2L2_9301;EGR1_8533 7.452825000000001 7.452825000000001 6.6423 1.1462554476424458 7.600331783446979 1.1271135918461097 2.46154 2.46154 1.51678 1.336092405187606 2.2896038984246414 1.3137803732550348 29.68675 29.68675 13.4683 22.93635195066992 32.63833248295321 22.553327082664484 0.0 6.6423 0.0 6.6423 6.6423;8.26335 3.4063;1.51678 13.4683;45.9052 1 1 1 83619 NFE2L2_9301 6.6423 6.6423 3.4063 3.4063 13.4683 13.4683 6.6423 3.4063 13.4683 1 24330 EGR1_8533 8.26335 8.26335 1.51678 1.51678 45.9052 45.9052 8.26335 1.51678 45.9052 0 Exp 4,1(0.5);Hill,1(0.5) 2.8563795452351224 6.832221508026123 1.5423688888549805 5.289852619171143 2.649871158092817 3.4161107540130615 5.864196 9.041454000000002 0.6098104 4.3132696 -2.1014119999999963 61.474911999999996 CONFLICT 0.5 0.5 0.0 GO:0014823 3 response to activity 61 66 5 4 3 3 2 2 50 64 2431 0.84977 0.39267 0.39267 3.03 116686;114628 gsr;abcg5 GSR_8755;ABCG5_7947 217.80110000000002 217.80110000000002 74.6342 202.4685716629127 231.24992960940784 201.57326329524514 165.46685 165.46685 57.2867 152.98983530955576 175.62909004619908 152.31332004303448 317.5585 317.5585 106.529 298.4407809608131 337.38221475570487 297.12108711276096 74.6342;360.968 57.2867;273.647 106.529;528.588 1 1 1 116686 GSR_8755 74.6342 74.6342 57.2867 57.2867 106.529 106.529 74.6342 57.2867 106.529 1 114628 ABCG5_7947 360.968 360.968 273.647 273.647 528.588 528.588 360.968 273.647 528.588 0 Linear,1(0.5);Poly 2,1(0.5) 2.054132581982195 4.112704396247864 1.9608341455459595 2.1518702507019043 0.13508292540723496 2.056352198123932 -62.80602399999998 498.408224 -46.56624399999998 377.49994399999997 -96.0593199999999 731.1763199999998 CONFLICT 0.5 0.5 0.0 GO:0043933 5 protein-containing complex subunit organization 226 259 7 6 4 5 3 3 49 256 2239 0.20892 0.91184 0.3609 1.16 360918;25333;24539 pf4;mgp;lpl PF4_32963;MGP_33209;LPL_32544 341.38883333333325 179.631 75.1005 374.36519196645855 405.4574546046463 418.91965593220345 189.64573333333337 110.795 13.9312 225.71720178669 220.34345468277945 258.3841456641553 985.3559999999999 426.677 346.231 1038.1082345020677 1209.8952975309928 1117.8994355609677 179.631;75.1005;769.435 110.795;13.9312;444.211 426.677;346.231;2183.16 1 2 1 360918 PF4_32963 179.631 179.631 110.795 110.795 426.677 426.677 179.631 110.795 426.677 2 25333;24539 MGP_33209;LPL_32544 422.26775 422.26775 490.9686333617708 229.0711 229.0711 304.25376438759145 1264.6954999999998 1264.6954999999998 1298.9049524582238 75.1005;769.435 13.9312;444.211 346.231;2183.16 0 Exp 2,1(0.34);Hill,1(0.34);Poly 2,1(0.34) 1.8514394926013096 5.568939566612244 1.6902254819869995 2.0189225673675537 0.16437614656845254 1.8597915172576904 -82.24526160650578 765.0229282731724 -65.77732560272477 445.06879226939145 -189.37405452996222 2160.086054529962 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:1904486 5 response to 17alpha-ethynylestradiol 6 6 1 1 1 1 1 1 51 5 2490 0.99418 0.11652 0.11652 16.67 170698 slco1a2 SLCO1A2_9886 440.994 440.994 440.994 440.994 299.351 299.351 299.351 299.351 772.521 772.521 772.521 772.521 0.0 440.994 0.0 440.994 440.994 299.351 772.521 0 1 0 1 170698 SLCO1A2_9886 440.994 440.994 299.351 299.351 772.521 772.521 440.994 299.351 772.521 0 Exp 2,1(1) 1.672735333442688 1.672735333442688 1.672735333442688 1.672735333442688 0.0 1.672735333442688 440.994 440.994 299.351 299.351 772.521 772.521 DOWN 0.0 1.0 0.0 GO:0048562 5 embryonic organ morphogenesis 19 20 2 2 2 2 2 2 50 18 2477 0.99284 0.061463 0.061463 10.0 25587;24188 id2;aldh1a1 ID2_8861;ALDH1A1_8022 45.75182 45.75182 2.99674 60.46481399634667 68.00049668229354 51.63319187679893 33.473622 33.473622 0.998544 45.92669574672413 50.372842178146406 39.218542769374125 72.2795 72.2795 10.914 86.78392236180619 104.21257482870537 74.1080740841955 0.0 2.99674 1.0 88.5069 2.99674;88.5069 0.998544;65.9487 10.914;133.645 2 0 2 25587;24188 ID2_8861;ALDH1A1_8022 45.75182 45.75182 60.46481399634667 33.473622 33.473622 45.92669574672413 72.2795 72.2795 86.78392236180619 2.99674;88.5069 0.998544;65.9487 10.914;133.645 0 0 Hill,1(0.5);Poly 2,1(0.5) 2.3528849483426324 4.776931166648865 1.9777342081069946 2.79919695854187 0.580861881324653 2.3884655833244324 -38.0481368 129.5517768 -30.177530879999985 97.12477487999999 -47.99687999999999 192.55588 UP 1.0 0.0 0.0 GO:0010906 6 regulation of glucose metabolic process 37 37 6 5 2 4 2 2 50 35 2460 0.96171 0.17365 0.17365 5.41 24484;297417 igfbp3;gfpt1 IGFBP3_8881;GFPT1_8705 513.20165 513.20165 44.9033 662.2738778069426 136.73006423173803 393.8844747431731 286.87275 286.87275 18.8755 379.00534562869296 71.42601676031776 225.41176164482502 2181.6225 2181.6225 122.765 2911.664199493564 526.4781931796164 1731.6994709858413 0.5 513.20165 44.9033;981.5 18.8755;554.87 122.765;4240.48 1 1 1 297417 GFPT1_8705 981.5 981.5 554.87 554.87 4240.48 4240.48 981.5 554.87 4240.48 1 24484 IGFBP3_8881 44.9033 44.9033 18.8755 18.8755 122.765 122.765 44.9033 18.8755 122.765 0 Exp 4,1(0.5);Linear,1(0.5) 1.587669177117761 3.17806339263916 1.5232417583465576 1.6548216342926025 0.09304102254913306 1.58903169631958 -404.66311599999995 1431.066416 -238.40186000000006 812.14736 -1853.7381999999993 6216.983199999999 CONFLICT 0.5 0.5 0.0 GO:0046394 6 carboxylic acid biosynthetic process 88 95 20 17 12 14 9 9 43 86 2409 0.99999 9.3089E-5 9.3089E-5 9.47 24539;24424;29277;24296;25612;64392;24188;24763;296925 lpl;gstm2;cyp2c11;cyp1a1;asns;aldh1l1;aldh1a1;acsm3;aass LPL_32544;GSTM2_8759;CYP2C11_32593;CYP1A1_8415;ASNS_8091;ALDH1L1_32662;ALDH1A1_8022;ACSM3_7976;AASS_7936 213.3092311111111 129.934 3.28268 246.94431459818063 263.3176659941968 294.3238644346933 125.81514411111112 65.9487 0.808077 154.91934153962887 159.18149518109732 176.18187221223965 592.6525999999999 355.143 13.1174 697.1535877720847 693.3707307728089 841.8978392223501 3.5 115.42150000000001 769.435;3.28268;129.934;100.909;154.987;184.03;88.5069;460.125;28.5735 444.211;0.808077;45.3106;73.3629;53.5946;111.154;65.9487;331.8;6.14642 2183.16;13.1174;355.143;159.385;462.615;1150.07;133.645;748.659;128.079 5 4 5 24424;24296;25612;64392;24188 GSTM2_8759;CYP1A1_8415;ASNS_8091;ALDH1L1_32662;ALDH1A1_8022 106.34311599999998 100.909 69.58913902802136 60.9736554 65.9487 39.908203158962785 383.76648 159.385 459.2729900886312 3.28268;100.909;154.987;184.03;88.5069 0.808077;73.3629;53.5946;111.154;65.9487 13.1174;159.385;462.615;1150.07;133.645 4 24539;29277;24763;296925 LPL_32544;CYP2C11_32593;ACSM3_7976;AASS_7936 347.01687499999997 295.0295 336.53215694253623 206.867005 188.55530000000002 214.7321202812909 853.7602499999999 551.901 922.6018293664118 769.435;129.934;460.125;28.5735 444.211;45.3106;331.8;6.14642 2183.16;355.143;748.659;128.079 0 Exp 2,1(0.12);Exp 4,2(0.23);Hill,2(0.23);Linear,1(0.12);Poly 2,3(0.34) 1.8879982418499441 17.364073991775513 1.6175053119659424 2.79919695854187 0.45717465835437343 1.7059084177017212 51.97227890696644 374.64618331525577 24.60117430522024 227.02911391700198 137.17892265557128 1048.1262773444287 CONFLICT 0.5555555555555556 0.4444444444444444 0.0 GO:0048522 5 positive regulation of cellular process 1060 1140 49 46 26 34 20 20 32 1120 1375 0.21787 0.85642 0.39942 1.75 246273;363140;360918;24614;24314;316351;83619;24539;29200;24484;494344;25587;24424;289388;24330;24296;25695;58919;25612;24188 trib3;rassf1;pf4;orm1;nqo1;npas2;nfe2l2;lpl;inhba;igfbp3;ier2;id2;gstm2;g0s2;egr1;cyp1a1;cebpd;ccnd1;asns;aldh1a1 TRIB3_10079;RASSF1_32475;PF4_32963;ORM1_9400;NQO1_33055;NPAS2_9350;NFE2L2_9301;LPL_32544;INHBA_33300;IGFBP3_8881;IER2_32643;ID2_8861;GSTM2_8759;G0S2_32729;EGR1_8533;CYP1A1_8415;CEBPD_8283;CCND1_8224;ASNS_8091;ALDH1A1_8022 177.206868 72.7446 2.99674 252.39522498207074 237.83403867714807 292.7322165426468 105.25349904999999 36.23505 0.808077 154.64906990089148 139.5167171708797 175.81011828441464 371.74071999999995 146.515 10.914 539.8559997361153 492.5473406479832 636.373327063858 16.8949;756.581;179.631;56.9823;24.1117;134.458;6.6423;769.435;130.168;44.9033;543.54;2.99674;3.28268;3.45084;8.26335;100.909;5.66035;512.733;154.987;88.5069 6.46469;437.5;110.795;16.0812;16.4151;56.7249;3.4063;444.211;89.164;18.8755;375.947;0.998544;0.808077;1.07374;1.51678;73.3629;2.15795;330.024;53.5946;65.9487 58.9909;940.187;426.677;262.985;37.0434;320.448;13.4683;2183.16;231.33;122.765;978.946;10.914;13.1174;14.3222;45.9052;159.385;16.35;1002.56;462.615;133.645 12 8 12 246273;363140;360918;24614;24314;83619;25587;24424;289388;24296;25612;24188 TRIB3_10079;RASSF1_32475;PF4_32963;ORM1_9400;NQO1_33055;NFE2L2_9301;ID2_8861;GSTM2_8759;G0S2_32729;CYP1A1_8415;ASNS_8091;ALDH1A1_8022 116.24803000000001 40.547 210.7875921166818 65.53740425 16.24815 122.59614098420381 211.1125166666667 96.31795000000001 280.1219013119526 16.8949;756.581;179.631;56.9823;24.1117;6.6423;2.99674;3.28268;3.45084;100.909;154.987;88.5069 6.46469;437.5;110.795;16.0812;16.4151;3.4063;0.998544;0.808077;1.07374;73.3629;53.5946;65.9487 58.9909;940.187;426.677;262.985;37.0434;13.4683;10.914;13.1174;14.3222;159.385;462.615;133.645 8 316351;24539;29200;24484;494344;24330;25695;58919 NPAS2_9350;LPL_32544;INHBA_33300;IGFBP3_8881;IER2_32643;EGR1_8533;CEBPD_8283;CCND1_8224 268.645125 132.313 295.23326019512814 164.82764125 72.94445 185.84223892927542 612.683025 275.889 746.444126877255 134.458;769.435;130.168;44.9033;543.54;8.26335;5.66035;512.733 56.7249;444.211;89.164;18.8755;375.947;1.51678;2.15795;330.024 320.448;2183.16;231.33;122.765;978.946;45.9052;16.35;1002.56 0 Exp 2,2(0.1);Exp 4,8(0.4);Hill,4(0.2);Linear,1(0.05);Poly 2,5(0.25) 2.05919646446803 44.19193708896637 1.5423688888549805 5.289852619171143 1.0314507455953235 1.874327003955841 66.58978346977244 287.82395253022764 37.47555579072004 173.03144230927995 135.13839615967177 608.3430438403283 UP 0.6 0.4 0.0 GO:0006796 5 phosphate-containing compound metabolic process 383 419 27 23 9 17 7 7 45 412 2083 0.35845 0.77627 0.70582 1.67 246273;24484;297417;58919;54232;24763;296925 trib3;igfbp3;gfpt1;ccnd1;car3;acsm3;aass TRIB3_10079;IGFBP3_8881;GFPT1_8705;CCND1_8224;CAR3_8196;ACSM3_7976;AASS_7936 299.9913857142857 55.21 16.8949 368.36460818816204 221.17692682323855 274.670287692459 181.83453000000003 24.6611 6.14642 222.29306797664884 138.45769108343634 180.35918005318652 915.4639857142856 128.079 58.9909 1512.5646321092422 512.1642062731768 829.6573870380313 16.8949;44.9033;981.5;512.733;55.21;460.125;28.5735 6.46469;18.8755;554.87;330.024;24.6611;331.8;6.14642 58.9909;122.765;4240.48;1002.56;106.714;748.659;128.079 2 5 2 246273;297417 TRIB3_10079;GFPT1_8705 499.19745 499.19745 682.0788073771278 280.667345 280.667345 387.7811135397107 2149.7354499999997 2149.7354499999997 2956.7592980676327 16.8949;981.5 6.46469;554.87 58.9909;4240.48 5 24484;58919;54232;24763;296925 IGFBP3_8881;CCND1_8224;CAR3_8196;ACSM3_7976;AASS_7936 220.30895999999998 55.21 243.82926966718532 142.301404 24.6611 172.30849188767536 421.7554 128.079 423.9964970365911 44.9033;512.733;55.21;460.125;28.5735 18.8755;330.024;24.6611;331.8;6.14642 122.765;1002.56;106.714;748.659;128.079 0 Exp 2,1(0.15);Exp 4,2(0.29);Exp 5,1(0.15);Hill,1(0.15);Linear,2(0.29) 1.8124580341789334 12.995684385299683 1.5232417583465576 2.7548160552978516 0.4712420484250178 1.620619773864746 27.103065096471028 572.8797063321005 17.157520708859124 346.5115392911409 -205.05957465814254 2035.9875460867138 DOWN 0.2857142857142857 0.7142857142857143 0.0 GO:0060548 6 negative regulation of cell death 321 341 12 12 8 7 5 5 47 336 2159 0.28477 0.84556 0.53882 1.47 360918;24314;316351;83619;25612 pf4;nqo1;npas2;nfe2l2;asns PF4_32963;NQO1_33055;NPAS2_9350;NFE2L2_9301;ASNS_8091 99.96599999999998 134.458 6.6423 79.0991601412114 96.21385215603586 70.16898124218066 48.18718 53.5946 3.4063 41.942413676694855 41.96814173958882 30.80245892148667 252.05034 320.448 13.4683 213.69344887938888 238.8426493990511 190.24186407976535 179.631;24.1117;134.458;6.6423;154.987 110.795;16.4151;56.7249;3.4063;53.5946 426.677;37.0434;320.448;13.4683;462.615 4 1 4 360918;24314;83619;25612 PF4_32963;NQO1_33055;NFE2L2_9301;ASNS_8091 91.34299999999999 89.54935 88.58063362492581 46.05275 35.00485 48.116346604212026 234.950925 231.86020000000002 242.76996005068085 179.631;24.1117;6.6423;154.987 110.795;16.4151;3.4063;53.5946 426.677;37.0434;13.4683;462.615 1 316351 NPAS2_9350 134.458 134.458 56.7249 56.7249 320.448 320.448 134.458 56.7249 320.448 0 Exp 4,3(0.6);Hill,1(0.2);Poly 2,1(0.2) 2.3263344281327862 12.699005246162415 1.5423688888549805 4.773829460144043 1.3115630079842902 1.8888624906539917 30.632529176754957 169.29947082324506 11.423033456369417 84.95132654363059 64.73977340804961 439.3609065919504 UP 0.8 0.2 0.0 GO:0042908 5 xenobiotic transport 11 11 2 2 2 2 2 2 50 9 2486 0.99882 0.01999 0.01999 18.18 266730;140668 slc17a3;abcc3 SLC17A3_9840;ABCC3_7941 72.6253 72.6253 58.7587 19.610333784002766 74.06353349366573 19.504567669020464 43.55765 43.55765 40.4498 4.395163619821223 43.23530609714789 4.371458802458012 93.45765 93.45765 78.8953 20.59427287002388 94.96804616895874 20.483199990982587 0.0 58.7587 0.5 72.6253 58.7587;86.4919 46.6655;40.4498 78.8953;108.02 2 0 2 266730;140668 SLC17A3_9840;ABCC3_7941 72.6253 72.6253 19.610333784002766 43.55765 43.55765 4.395163619821223 93.45765 93.45765 20.59427287002388 58.7587;86.4919 46.6655;40.4498 78.8953;108.02 0 0 Exp 5,1(0.5);Poly 2,1(0.5) 2.459335074927584 5.164258241653442 1.7953243255615234 3.368933916091919 1.112710012404229 2.582129120826721 45.44676399999999 99.803836 37.466264 49.649036 64.91544400000001 121.999856 UP 1.0 0.0 0.0 GO:0045596 6 negative regulation of cell differentiation 184 195 12 12 7 8 5 5 47 190 2305 0.79639 0.36702 0.59335 2.56 246273;360918;83619;25587;58919 trib3;pf4;nfe2l2;id2;ccnd1 TRIB3_10079;PF4_32963;NFE2L2_9301;ID2_8861;CCND1_8224 143.779588 16.8949 2.99674 219.1678090349258 234.6774855603868 271.77136802605816 90.3377068 6.46469 0.998544 141.8108409450704 149.7430438302291 176.0258307483644 302.52204 58.9909 10.914 428.18288419899847 468.55879399701473 525.7796057364534 16.8949;179.631;6.6423;2.99674;512.733 6.46469;110.795;3.4063;0.998544;330.024 58.9909;426.677;13.4683;10.914;1002.56 4 1 4 246273;360918;83619;25587 TRIB3_10079;PF4_32963;NFE2L2_9301;ID2_8861 51.541235 11.7686 85.59563615361611 30.4161335 4.9354949999999995 53.632575621061825 127.51255 36.229600000000005 200.66215178975995 16.8949;179.631;6.6423;2.99674 6.46469;110.795;3.4063;0.998544 58.9909;426.677;13.4683;10.914 1 58919 CCND1_8224 512.733 512.733 330.024 330.024 1002.56 1002.56 512.733 330.024 1002.56 0 Exp 2,1(0.2);Exp 4,2(0.4);Hill,1(0.2);Poly 2,1(0.2) 1.8210058295157394 9.204574465751648 1.5423688888549805 2.2692105770111084 0.30541854993277057 1.8597915172576904 -48.329466836860405 335.8886428368604 -33.96497587743842 214.64038947743842 -72.7968060613855 677.8408860613854 UP 0.8 0.2 0.0 GO:0002682 4 regulation of immune system process 334 363 15 14 7 9 6 6 46 357 2138 0.3732 0.77222 0.69125 1.65 360918;24614;83619;29200;25587;117517 pf4;orm1;nfe2l2;inhba;id2;c7 PF4_32963;ORM1_9400;NFE2L2_9301;INHBA_33300;ID2_8861;C7_8179 65.04387333333334 35.4126 2.99674 73.9168189648355 54.82424768900548 53.34506269108373 37.628984 10.705029999999999 0.998544 49.0504026729975 26.1040609310756 36.94878090757691 164.54510000000002 136.61315000000002 10.914 169.90186126380138 176.56650817553063 137.5201992793429 179.631;56.9823;6.6423;130.168;2.99674;13.8429 110.795;16.0812;3.4063;89.164;0.998544;5.32886 426.677;262.985;13.4683;231.33;10.914;41.8963 4 2 4 360918;24614;83619;25587 PF4_32963;ORM1_9400;NFE2L2_9301;ID2_8861 61.563085 31.8123 82.47691704418212 32.820261 9.743749999999999 52.402477230939674 178.511075 138.22665 203.347049371485 179.631;56.9823;6.6423;2.99674 110.795;16.0812;3.4063;0.998544 426.677;262.985;13.4683;10.914 2 29200;117517 INHBA_33300;C7_8179 72.00545 72.00545 82.25426703220327 47.246430000000004 47.246430000000004 59.28039599572358 136.61315000000002 136.61315000000002 133.94985385525808 130.168;13.8429 89.164;5.32886 231.33;41.8963 0 Exp 4,2(0.34);Hill,2(0.34);Poly 2,2(0.34) 1.8187784883884668 11.061822295188904 1.5423688888549805 2.4614932537078857 0.34670587335090425 1.7477684020996094 5.898099974648289 124.18964669201841 -1.6195123541180365 76.87748035411803 28.595296961152343 300.4949030388476 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0019538 4 protein metabolic process 588 639 22 20 8 13 6 6 46 633 1862 0.012509 0.99571 0.022777 0.94 246273;83619;29200;24484;297417;58919 trib3;nfe2l2;inhba;igfbp3;gfpt1;ccnd1 TRIB3_10079;NFE2L2_9301;INHBA_33300;IGFBP3_8881;GFPT1_8705;CCND1_8224 282.14025 87.53565 6.6423 391.89494195225717 203.5418784536203 282.6207314912362 167.13408166666667 54.01975 3.4063 226.95975345482557 124.42707821967484 175.21152368978298 944.9323666666666 177.0475 13.4683 1655.3948323023778 502.0911899910321 933.7670649621787 16.8949;6.6423;130.168;44.9033;981.5;512.733 6.46469;3.4063;89.164;18.8755;554.87;330.024 58.9909;13.4683;231.33;122.765;4240.48;1002.56 3 3 3 246273;83619;297417 TRIB3_10079;NFE2L2_9301;GFPT1_8705 335.0124 16.8949 559.8981529412381 188.24699666666666 6.46469 317.50851699948623 1437.6463999999999 58.9909 2427.4318154676166 16.8949;6.6423;981.5 6.46469;3.4063;554.87 58.9909;13.4683;4240.48 3 29200;24484;58919 INHBA_33300;IGFBP3_8881;CCND1_8224 229.2681 130.168 249.1621548621098 146.02116666666666 89.164 163.18057578671346 452.2183333333333 231.33 479.69110097888336 130.168;44.9033;512.733 89.164;18.8755;330.024 231.33;122.765;1002.56 0 Exp 2,1(0.17);Exp 4,3(0.5);Linear,1(0.17);Poly 2,1(0.17) 1.6795516588000352 10.180857419967651 1.5232417583465576 2.2692105770111084 0.28533823248859375 1.5956072807312012 -31.441012583149927 595.7215125831499 -14.471543783316804 348.7397071166501 -379.6593695804454 2269.5241029137787 CONFLICT 0.5 0.5 0.0 GO:0006464 6 cellular protein modification process 420 450 18 17 6 11 5 5 47 445 2050 0.081202 0.9661 0.143 1.11 246273;83619;24484;297417;58919 trib3;nfe2l2;igfbp3;gfpt1;ccnd1 TRIB3_10079;NFE2L2_9301;IGFBP3_8881;GFPT1_8705;CCND1_8224 312.5347 44.9033 6.6423 430.1725089759747 212.97635470627063 304.8348299779025 182.728098 18.8755 3.4063 250.1291906591712 128.9612350759076 189.37907185440068 1087.65284 122.765 13.4683 1809.0457601186024 536.9058961364136 1005.8511275398733 16.8949;6.6423;44.9033;981.5;512.733 6.46469;3.4063;18.8755;554.87;330.024 58.9909;13.4683;122.765;4240.48;1002.56 3 2 3 246273;83619;297417 TRIB3_10079;NFE2L2_9301;GFPT1_8705 335.0124 16.8949 559.8981529412381 188.24699666666666 6.46469 317.50851699948623 1437.6463999999999 58.9909 2427.4318154676166 16.8949;6.6423;981.5 6.46469;3.4063;554.87 58.9909;13.4683;4240.48 2 24484;58919 IGFBP3_8881;CCND1_8224 278.81814999999995 278.81814999999995 330.8055533104682 174.44975 174.44975 220.01521430602247 562.6625 562.6625 622.1090105540184 44.9033;512.733 18.8755;330.024 122.765;1002.56 0 Exp 2,1(0.2);Exp 4,3(0.6);Linear,1(0.2) 1.6884527194623242 8.545112133026123 1.5232417583465576 2.2692105770111084 0.3172597195519901 1.555469274520874 -64.5281290717918 689.5975290717918 -36.51980440059759 401.97600040059757 -498.04568326092567 2673.3513632609256 UP 0.6 0.4 0.0 GO:0008152 2 metabolic process 1361 1509 85 81 41 66 33 33 19 1476 1019 0.77744 0.31729 0.57115 2.19 286954;246273;24902;305291;266730;299270;501907;24314;83619;307126;24539;29200;24484;24424;300850;116686;297417;246248;25598;25315;24330;499353;29277;24296;290277;58919;54232;25612;64392;24188;26760;24763;296925 ugt2b1;trib3;sult2a6;srd5a3;slc17a3;serpina6;rgd1559459;nqo1;nfe2l2;mcm10;lpl;inhba;igfbp3;gstm2;gsta4;gsr;gfpt1;fmo5;fabp2;ephx1;egr1;cyp2c24;cyp2c11;cyp1a1;cryl1;ccnd1;car3;asns;aldh1l1;aldh1a1;akr7a3;acsm3;aass UGT2B10_33303,UGT2B1_33224;TRIB3_10079;SULT2A6_32471,SULT2A6_9972;SRD5A3_9939;SLC17A3_9840;SERPINA6_32325;RGD1559459_9690;NQO1_33055;NFE2L2_9301;MCM10_32579;LPL_32544;INHBA_33300;IGFBP3_8881;GSTM2_8759;GSTA4_8757;GSR_8755;GFPT1_8705;FMO5_33281;FABP2_32859;EPHX1_8567;EGR1_8533;CYP2C24_32875;CYP2C11_32593;CYP1A1_8415;CRYL1_8388;CCND1_8224;CAR3_8196;ASNS_8091;ALDH1L1_32662;ALDH1A1_8022;AKR7A3_8015;ACSM3_7976;AASS_7936 167.12916606060608 74.6342 3.28268 243.3332837723209 187.7191846954403 246.0684836093404 99.66025354545455 45.3106 0.808077 147.58166838882988 114.76920544317441 151.55645562012114 471.1271863636363 133.645 13.1174 844.6812382301728 473.0636429544219 690.1891374163964 25.4966;16.8949;50.527550000000005;169.209;58.7587;15.8474;42.78;24.1117;6.6423;213.608;769.435;130.168;44.9033;3.28268;105.355;74.6342;981.5;57.4978;146.645;24.8784;8.26335;733.935;129.934;100.909;76.0301;512.733;55.21;154.987;184.03;88.5069;19.8501;460.125;28.5735 11.3392;6.46469;20.8664;105.547;46.6655;7.7531;20.6065;16.4151;3.4063;123.177;444.211;89.164;18.8755;0.808077;75.6422;57.2867;554.87;31.5489;95.8536;15.4867;1.51678;463.206;45.3106;73.3629;23.2788;330.024;24.6611;53.5946;111.154;65.9487;12.797;331.8;6.14642 63.97775;58.9909;154.361;459.211;78.8953;40.8362;93.6128;37.0434;13.4683;668.095;2183.16;231.33;122.765;13.1174;172.041;106.529;4240.48;109.026;319.535;41.3795;45.9052;1763.75;355.143;159.385;250.463;1002.56;106.714;462.615;1150.07;133.645;32.3544;748.659;128.079 23 12 21 286954;246273;24902;305291;266730;501907;24314;83619;24424;300850;116686;297417;246248;25598;25315;24296;290277;25612;64392;24188;26760 UGT2B10_33303,UGT2B1_33224;TRIB3_10079;SULT2A6_32471,SULT2A6_9972;SRD5A3_9939;SLC17A3_9840;RGD1559459_9690;NQO1_33055;NFE2L2_9301;GSTM2_8759;GSTA4_8757;GSR_8755;GFPT1_8705;FMO5_33281;FABP2_32859;EPHX1_8567;CYP1A1_8415;CRYL1_8388;ASNS_8091;ALDH1L1_32662;ALDH1A1_8022;AKR7A3_8015 114.88223476190475 58.7587 205.96156443259233 66.80680319047619 31.5489 117.02045532456549 388.1047976190476 109.026 918.6373622717034 25.4966;16.8949;50.527550000000005;169.209;58.7587;42.78;24.1117;6.6423;3.28268;105.355;74.6342;981.5;57.4978;146.645;24.8784;100.909;76.0301;154.987;184.03;88.5069;19.8501 11.3392;6.46469;20.8664;105.547;46.6655;20.6065;16.4151;3.4063;0.808077;75.6422;57.2867;554.87;31.5489;95.8536;15.4867;73.3629;23.2788;53.5946;111.154;65.9487;12.797 63.97775;58.9909;154.361;459.211;78.8953;93.6128;37.0434;13.4683;13.1174;172.041;106.529;4240.48;109.026;319.535;41.3795;159.385;250.463;462.615;1150.07;133.645;32.3544 12 299270;307126;24539;29200;24484;24330;499353;29277;58919;54232;24763;296925 SERPINA6_32325;MCM10_32579;LPL_32544;INHBA_33300;IGFBP3_8881;EGR1_8533;CYP2C24_32875;CYP2C11_32593;CCND1_8224;CAR3_8196;ACSM3_7976;AASS_7936 258.5612958333333 130.051 284.23883564306396 157.15379166666665 67.2373 181.09841809993662 616.4163666666667 293.2365 710.6730573643849 15.8474;213.608;769.435;130.168;44.9033;8.26335;733.935;129.934;512.733;55.21;460.125;28.5735 7.7531;123.177;444.211;89.164;18.8755;1.51678;463.206;45.3106;330.024;24.6611;331.8;6.14642 40.8362;668.095;2183.16;231.33;122.765;45.9052;1763.75;355.143;1002.56;106.714;748.659;128.079 0 Exp 2,2(0.06);Exp 4,14(0.4);Exp 5,2(0.06);Hill,4(0.12);Linear,3(0.09);Poly 2,10(0.29) 2.0258559714244884 75.06003451347351 1.5232417583465576 5.289852619171143 0.887129723825192 1.7953243255615234 84.10574625663303 250.152585864579 49.30653859094367 150.01396849996544 182.92853160114123 759.3258411261315 UP 0.6363636363636364 0.36363636363636365 0.0 GO:1900087 9 positive regulation of G1/S transition of mitotic cell cycle 15 16 2 2 2 2 2 2 50 14 2481 0.99627 0.040873 0.040873 12.5 24296;58919 cyp1a1;ccnd1 CYP1A1_8415;CCND1_8224 306.82099999999997 306.82099999999997 100.909 291.2035430553687 265.1282294514306 285.1717539588532 201.69344999999998 201.69344999999998 73.3629 181.48680427679864 175.70926172772005 177.72761194104433 580.9725 580.9725 159.385 596.2147602269671 495.6100592309094 583.8651794073585 0.0 100.909 0.5 306.82099999999997 100.909;512.733 73.3629;330.024 159.385;1002.56 1 1 1 24296 CYP1A1_8415 100.909 100.909 73.3629 73.3629 159.385 159.385 100.909 73.3629 159.385 1 58919 CCND1_8224 512.733 512.733 330.024 330.024 1002.56 1002.56 512.733 330.024 1002.56 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.7219256686678825 3.4616644382476807 1.555469274520874 1.9061951637268066 0.2480006545951967 1.7308322191238403 -96.76652000000001 710.40852 -49.834428 453.221328 -245.33899999999994 1407.2839999999999 CONFLICT 0.5 0.5 0.0 GO:0071417 5 cellular response to organonitrogen compound 203 213 20 19 11 12 7 7 45 206 2289 0.93607 0.13893 0.19837 3.29 286954;246273;24614;83619;24424;297417;24330 ugt2b1;trib3;orm1;nfe2l2;gstm2;gfpt1;egr1 UGT2B10_33303,UGT2B1_33224;TRIB3_10079;ORM1_9400;NFE2L2_9301;GSTM2_8759;GFPT1_8705;EGR1_8533 157.00887571428572 16.8949 3.28268 364.02504870084306 65.71000705203188 198.7885093964954 84.92660671428573 6.46469 0.808077 207.29871697647323 30.049923110215207 113.32826940935213 671.2749357142857 58.9909 13.1174 1576.2082821785762 280.9767931567391 861.052736256089 25.4966;16.8949;56.9823;6.6423;3.28268;981.5;8.26335 11.3392;6.46469;16.0812;3.4063;0.808077;554.87;1.51678 63.97775;58.9909;262.985;13.4683;13.1174;4240.48;45.9052 7 1 6 286954;246273;24614;83619;24424;297417 UGT2B10_33303,UGT2B1_33224;TRIB3_10079;ORM1_9400;NFE2L2_9301;GSTM2_8759;GFPT1_8705 181.79979666666668 21.19575 392.24294678168127 98.8282445 8.901945 223.4814605148684 775.5032249999999 61.484325 1700.0192215841628 25.4966;16.8949;56.9823;6.6423;3.28268;981.5 11.3392;6.46469;16.0812;3.4063;0.808077;554.87 63.97775;58.9909;262.985;13.4683;13.1174;4240.48 1 24330 EGR1_8533 8.26335 8.26335 1.51678 1.51678 45.9052 45.9052 8.26335 1.51678 45.9052 0 Exp 4,5(0.63);Hill,2(0.25);Linear,1(0.13) 1.9630220800434124 17.316559314727783 1.5232417583465576 5.289852619171143 1.2847385505555438 1.7006439566612244 -112.6646542466842 426.6824056752556 -68.64243190801751 238.49564533658895 -496.3965004294678 1838.9463718580391 UP 0.8571428571428571 0.14285714285714285 0.0 GO:0007346 6 regulation of mitotic cell cycle 146 155 6 6 5 4 4 4 48 151 2344 0.79334 0.39091 0.55493 2.58 25587;24296;58919;25612 id2;cyp1a1;ccnd1;asns ID2_8861;CYP1A1_8415;CCND1_8224;ASNS_8091 192.906435 127.94800000000001 2.99674 222.30319800667934 225.9936410807506 225.07919928576976 114.495011 63.47875 0.998544 146.89554535579518 143.1962702713634 146.06915094270195 408.8685 311.0 10.914 438.16590627942134 445.77768518083053 449.67851269950495 2.99674;100.909;512.733;154.987 0.998544;73.3629;330.024;53.5946 10.914;159.385;1002.56;462.615 3 1 3 25587;24296;25612 ID2_8861;CYP1A1_8415;ASNS_8091 86.29758 100.909 77.04141729958764 42.652014666666666 53.5946 37.40260866780076 210.97133333333332 159.385 230.226650695208 2.99674;100.909;154.987 0.998544;73.3629;53.5946 10.914;159.385;462.615 1 58919 CCND1_8224 512.733 512.733 330.024 330.024 1002.56 1002.56 512.733 330.024 1002.56 0 Exp 2,1(0.25);Exp 4,1(0.25);Hill,1(0.25);Poly 2,1(0.25) 1.9824827904410862 8.073551535606384 1.555469274520874 2.634152889251709 0.45007410817206434 1.9419646859169006 -24.950699046545765 410.76356904654574 -29.46262344867931 258.4526454486793 -20.534088153832897 838.2710881538328 UP 0.75 0.25 0.0 GO:0010744 7 positive regulation of macrophage derived foam cell differentiation 6 6 2 2 2 2 2 2 50 4 2491 0.99985 0.00582 0.00582 33.33 360918;24539 pf4;lpl PF4_32963;LPL_32544 474.53299999999996 474.53299999999996 179.631 417.05440797095054 709.7640459321525 251.52949979541395 277.503 277.503 110.795 235.760714556094 410.4790300210147 142.1895404300204 1304.9185 1304.9185 426.677 1242.02104033889 2005.4551753227258 749.0747610886793 0.0 179.631 0.0 179.631 179.631;769.435 110.795;444.211 426.677;2183.16 1 1 1 360918 PF4_32963 179.631 179.631 110.795 110.795 426.677 426.677 179.631 110.795 426.677 1 24539 LPL_32544 769.435 769.435 444.211 444.211 2183.16 2183.16 769.435 444.211 2183.16 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.7729825192742914 3.55001699924469 1.6902254819869995 1.8597915172576904 0.11990129339882284 1.775008499622345 -103.47491999999988 1052.54092 -49.24467999999996 604.2506799999999 -416.4348399999999 3026.2718399999994 CONFLICT 0.5 0.5 0.0 GO:0060255 5 regulation of macromolecule metabolic process 1000 1070 50 46 26 34 21 21 31 1049 1446 0.4639 0.64621 0.88753 1.96 24522;308843;246273;170698;299270;363140;360918;24614;316351;83619;59107;24539;29200;24484;494344;25587;297417;24330;289185;25695;58919 zfp354a;tsku;trib3;slco1a2;serpina6;rassf1;pf4;orm1;npas2;nfe2l2;ltbp1;lpl;inhba;igfbp3;ier2;id2;gfpt1;egr1;creg1;cebpd;ccnd1 ZFP354A_10203;TSKU_10094;TRIB3_10079;SLCO1A2_9886;SERPINA6_32325;RASSF1_32475;PF4_32963;ORM1_9400;NPAS2_9350;NFE2L2_9301;LTBP1_33264;LPL_32544;INHBA_33300;IGFBP3_8881;IER2_32643;ID2_8861;GFPT1_8705;EGR1_8533;CREG1_8380;CEBPD_8283;CCND1_8224 271.8915538095238 94.3216 2.99674 346.98069132414963 304.10886713374975 354.88442280506337 158.8294659047619 56.7249 0.998544 199.10895998329983 173.8376466478386 202.40871999155834 806.1841285714285 231.33 6.6682 1390.3382790109333 849.1541153013256 1366.0518090209023 3.26713;6.12626;16.8949;440.994;15.8474;756.581;179.631;56.9823;134.458;6.6423;998.777;769.435;130.168;44.9033;543.54;2.99674;981.5;8.26335;94.3216;5.66035;512.733 1.71987;1.46625;6.46469;299.351;7.7531;437.5;110.795;16.0812;56.7249;3.4063;507.146;444.211;89.164;18.8755;375.947;0.998544;554.87;1.51678;69.2457;2.15795;330.024 6.6682;41.3339;58.9909;772.521;40.8362;940.187;426.677;262.985;320.448;13.4683;5065.92;2183.16;231.33;122.765;978.946;10.914;4240.48;45.9052;147.421;16.35;1002.56 8 13 8 246273;363140;360918;24614;83619;25587;297417;289185 TRIB3_10079;RASSF1_32475;PF4_32963;ORM1_9400;NFE2L2_9301;ID2_8861;GFPT1_8705;CREG1_8380 261.94373 75.65195 383.8880601755217 149.92017925 42.66345 219.3698709299365 762.6404 205.203 1438.719020927516 16.8949;756.581;179.631;56.9823;6.6423;2.99674;981.5;94.3216 6.46469;437.5;110.795;16.0812;3.4063;0.998544;554.87;69.2457 58.9909;940.187;426.677;262.985;13.4683;10.914;4240.48;147.421 13 24522;308843;170698;299270;316351;59107;24539;29200;24484;494344;24330;25695;58919 ZFP354A_10203;TSKU_10094;SLCO1A2_9886;SERPINA6_32325;NPAS2_9350;LTBP1_33264;LPL_32544;INHBA_33300;IGFBP3_8881;IER2_32643;EGR1_8533;CEBPD_8283;CCND1_8224 278.01329153846154 130.168 338.5068741896013 164.31210384615386 56.7249 194.72198188613686 832.9802692307693 231.33 1418.5356525898749 3.26713;6.12626;440.994;15.8474;134.458;998.777;769.435;130.168;44.9033;543.54;8.26335;5.66035;512.733 1.71987;1.46625;299.351;7.7531;56.7249;507.146;444.211;89.164;18.8755;375.947;1.51678;2.15795;330.024 6.6682;41.3339;772.521;40.8362;320.448;5065.92;2183.16;231.33;122.765;978.946;45.9052;16.35;1002.56 0 Exp 2,4(0.2);Exp 4,7(0.34);Hill,4(0.2);Linear,2(0.1);Poly 2,4(0.2) 1.9792228940794878 45.63521432876587 1.5232417583465576 6.495501518249512 1.2746513871024832 1.6902254819869995 123.48546075929505 420.2976468597526 73.6691570424708 243.98977476705304 211.5266240896201 1400.841633053237 DOWN 0.38095238095238093 0.6190476190476191 0.0 GO:0021960 12 anterior commissure morphogenesis 1 1 1 1 1 1 1 1 51 0 2495 1.0 0.020416 0.020416 100.0 308843 tsku TSKU_10094 6.12626 6.12626 6.12626 6.12626 1.46625 1.46625 1.46625 1.46625 41.3339 41.3339 41.3339 41.3339 0.0 6.12626 0.0 6.12626 6.12626 1.46625 41.3339 0 1 0 1 308843 TSKU_10094 6.12626 6.12626 1.46625 1.46625 41.3339 41.3339 6.12626 1.46625 41.3339 0 Hill,1(1) 2.3648924827575684 2.3648924827575684 2.3648924827575684 2.3648924827575684 0.0 2.3648924827575684 6.12626 6.12626 1.46625 1.46625 41.3339 41.3339 DOWN 0.0 1.0 0.0 GO:0008283 3 cell population proliferation 139 149 10 9 7 8 6 6 46 143 2352 0.97041 0.079959 0.12207 4.03 307126;24484;25587;24330;24296;58919 mcm10;igfbp3;id2;egr1;cyp1a1;ccnd1 MCM10_32579;IGFBP3_8881;ID2_8861;EGR1_8533;CYP1A1_8415;CCND1_8224 147.23556499999998 72.90615 2.99674 195.309924675386 160.48917815537538 184.61236480275974 91.32578733333332 46.1192 0.998544 126.3231685962864 99.69130297562644 119.62514154621927 334.93736666666666 141.075 10.914 405.23585017133746 366.3531661310018 388.26232757754286 213.608;44.9033;2.99674;8.26335;100.909;512.733 123.177;18.8755;0.998544;1.51678;73.3629;330.024 668.095;122.765;10.914;45.9052;159.385;1002.56 2 4 2 25587;24296 ID2_8861;CYP1A1_8415 51.952870000000004 51.952870000000004 69.23442300730035 37.180721999999996 37.180721999999996 51.16932684379743 85.14949999999999 85.14949999999999 104.9848509095479 2.99674;100.909 0.998544;73.3629 10.914;159.385 4 307126;24484;24330;58919 MCM10_32579;IGFBP3_8881;EGR1_8533;CCND1_8224 194.8769125 129.25565 230.00003779346198 118.39832 71.02625 150.96837451546907 459.8313 395.43 455.65949179852856 213.608;44.9033;8.26335;512.733 123.177;18.8755;1.51678;330.024 668.095;122.765;45.9052;1002.56 0 Exp 2,1(0.17);Exp 4,1(0.17);Hill,2(0.34);Poly 2,2(0.34) 2.1822580721722713 14.488070130348206 1.555469274520874 5.289852619171143 1.4232531492146827 1.9419646859169006 -9.044923004330286 303.5160530043303 -9.753799212474718 192.4053738791414 10.681154255114052 659.1935790782193 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0044282 4 small molecule catabolic process 107 120 11 11 5 8 4 4 48 116 2379 0.90477 0.22755 0.30676 3.33 305291;24296;64392;296925 srd5a3;cyp1a1;aldh1l1;aass SRD5A3_9939;CYP1A1_8415;ALDH1L1_32662;AASS_7936 120.680375 135.059 28.5735 71.28063347007961 105.73974655159131 65.83564952100375 74.05258 89.45495 6.14642 48.236003433123116 66.321958898821 46.13067506109958 474.18625 309.298 128.079 474.66941377859666 324.2429331124298 356.8961879417238 169.209;100.909;184.03;28.5735 105.547;73.3629;111.154;6.14642 459.211;159.385;1150.07;128.079 3 1 3 305291;24296;64392 SRD5A3_9939;CYP1A1_8415;ALDH1L1_32662 151.38266666666667 169.209 44.33518670687345 96.68796666666667 105.547 20.39371627495424 589.5553333333334 459.211 508.04175638458423 169.209;100.909;184.03 105.547;73.3629;111.154 459.211;159.385;1150.07 1 296925 AASS_7936 28.5735 28.5735 6.14642 6.14642 128.079 128.079 28.5735 6.14642 128.079 0 Hill,1(0.25);Poly 2,3(0.75) 1.6983917821456 6.8171714544296265 1.5321133136749268 1.9061951637268066 0.1645182937076421 1.6894314885139465 50.82535419932198 190.53539580067803 26.78129663553934 121.32386336446066 9.010224496975184 939.3622755030246 UP 0.75 0.25 0.0 GO:0030154 4 cell differentiation 405 432 21 19 10 18 9 9 43 423 2072 0.61436 0.53168 1.0 2.08 25333;29200;24484;494344;25587;24330;24296;25695;58919 mgp;inhba;igfbp3;ier2;id2;egr1;cyp1a1;cebpd;ccnd1 MGP_33209;INHBA_33300;IGFBP3_8881;IER2_32643;ID2_8861;EGR1_8533;CYP1A1_8415;CEBPD_8283;CCND1_8224 158.25269333333333 75.1005 2.99674 214.42587742790812 145.78921895208916 196.732089878787 100.66420822222223 18.8755 0.998544 147.03022364378378 89.29680638730991 134.8412992286051 323.82068888888887 159.385 10.914 393.0778072687659 314.66663502879084 363.4672727647541 75.1005;130.168;44.9033;543.54;2.99674;8.26335;100.909;5.66035;512.733 13.9312;89.164;18.8755;375.947;0.998544;1.51678;73.3629;2.15795;330.024 346.231;231.33;122.765;978.946;10.914;45.9052;159.385;16.35;1002.56 2 7 2 25587;24296 ID2_8861;CYP1A1_8415 51.952870000000004 51.952870000000004 69.23442300730035 37.180721999999996 37.180721999999996 51.16932684379743 85.14949999999999 85.14949999999999 104.9848509095479 2.99674;100.909 0.998544;73.3629 10.914;159.385 7 25333;29200;24484;494344;24330;25695;58919 MGP_33209;INHBA_33300;IGFBP3_8881;IER2_32643;EGR1_8533;CEBPD_8283;CCND1_8224 188.62407142857143 75.1005 235.93007467731098 118.80234714285714 18.8755 163.27968983613025 392.01245714285716 231.33 423.9852175101504 75.1005;130.168;44.9033;543.54;8.26335;5.66035;512.733 13.9312;89.164;18.8755;375.947;1.51678;2.15795;330.024 346.231;231.33;122.765;978.946;45.9052;16.35;1002.56 0 Exp 2,1(0.12);Exp 4,2(0.23);Hill,3(0.34);Linear,1(0.12);Poly 2,2(0.23) 1.9565440305869266 19.18736505508423 1.555469274520874 5.289852619171143 1.1983329068668613 1.6548216342926025 18.161120080433363 298.3442665862333 4.604462108283485 196.72395433616094 67.00985480662843 580.6315229711493 DOWN 0.2222222222222222 0.7777777777777778 0.0 GO:0034762 5 regulation of transmembrane transport 122 128 7 7 6 4 3 3 49 125 2370 0.73638 0.49035 0.74412 2.34 246273;83619;24424 trib3;nfe2l2;gstm2 TRIB3_10079;NFE2L2_9301;GSTM2_8759 8.93996 6.6423 3.28268 7.091019985784838 9.63975446024376 6.565152663714695 3.559689 3.4063 0.808077 2.831424340669021 4.056600577626233 2.391076256132244 28.525533333333332 13.4683 13.1174 26.384364826603914 29.002809329657573 26.504046945101212 16.8949;6.6423;3.28268 6.46469;3.4063;0.808077 58.9909;13.4683;13.1174 3 0 3 246273;83619;24424 TRIB3_10079;NFE2L2_9301;GSTM2_8759 8.93996 6.6423 7.091019985784838 3.559689 3.4063 2.831424340669021 28.525533333333332 13.4683 26.384364826603914 16.8949;6.6423;3.28268 6.46469;3.4063;0.808077 58.9909;13.4683;13.1174 0 0 Exp 4,2(0.67);Hill,1(0.34) 1.81414887003422 5.51748788356781 1.5423688888549805 2.2692105770111084 0.3813033219148246 1.7059084177017212 0.9157154966610896 16.96420450333891 0.355630733660377 6.763747266339623 -1.331186131339301 58.38225279800597 UP 1.0 0.0 0.0 GO:0034641 4 cellular nitrogen compound metabolic process 478 543 32 29 15 23 11 11 41 532 1963 0.56844 0.56727 1.0 2.03 266730;307126;24424;300850;116686;297417;24330;25612;64392;24763;296925 slc17a3;mcm10;gstm2;gsta4;gsr;gfpt1;egr1;asns;aldh1l1;acsm3;aass SLC17A3_9840;MCM10_32579;GSTM2_8759;GSTA4_8757;GSR_8755;GFPT1_8705;EGR1_8533;ASNS_8091;ALDH1L1_32662;ACSM3_7976;AASS_7936 206.64703909090912 105.355 3.28268 288.07268118416715 148.10129401406687 185.04187855446986 123.87829790909092 57.2867 0.808077 170.5256206174235 92.08334615354593 118.49129469996589 710.407809090909 172.041 13.1174 1226.3591757366632 422.60626286889 681.4957997790007 58.7587;213.608;3.28268;105.355;74.6342;981.5;8.26335;154.987;184.03;460.125;28.5735 46.6655;123.177;0.808077;75.6422;57.2867;554.87;1.51678;53.5946;111.154;331.8;6.14642 78.8953;668.095;13.1174;172.041;106.529;4240.48;45.9052;462.615;1150.07;748.659;128.079 7 4 7 266730;24424;300850;116686;297417;25612;64392 SLC17A3_9840;GSTM2_8759;GSTA4_8757;GSR_8755;GFPT1_8705;ASNS_8091;ALDH1L1_32662 223.22108285714285 105.355 339.74745495585995 128.57443957142857 57.2867 190.86226905102248 889.1068142857142 172.041 1529.2760188580958 58.7587;3.28268;105.355;74.6342;981.5;154.987;184.03 46.6655;0.808077;75.6422;57.2867;554.87;53.5946;111.154 78.8953;13.1174;172.041;106.529;4240.48;462.615;1150.07 4 307126;24330;24763;296925 MCM10_32579;EGR1_8533;ACSM3_7976;AASS_7936 177.6424625 121.09075 209.76236015406965 115.66005000000001 64.66171 154.6985280746338 397.68455 398.087 361.819816897504 213.608;8.26335;460.125;28.5735 123.177;1.51678;331.8;6.14642 668.095;45.9052;748.659;128.079 0 Exp 4,1(0.1);Hill,3(0.28);Linear,2(0.19);Poly 2,5(0.46) 2.0413056709119997 24.08377468585968 1.5232417583465576 5.289852619171143 1.0747461087776902 1.7953243255615234 36.406963468588145 376.88711471323006 23.104095960749646 224.65249985743216 -14.324150771904101 1435.139768953722 UP 0.6363636363636364 0.36363636363636365 0.0 GO:1901700 4 response to oxygen-containing compound 599 638 50 45 27 36 22 22 30 616 1879 0.9982 0.0044199 0.0056533 3.45 24522;286954;246273;170698;360918;24614;24314;83619;59107;24539;29200;24484;24424;116686;297417;24330;24296;58919;54232;25612;24188;140668 zfp354a;ugt2b1;trib3;slco1a2;pf4;orm1;nqo1;nfe2l2;ltbp1;lpl;inhba;igfbp3;gstm2;gsr;gfpt1;egr1;cyp1a1;ccnd1;car3;asns;aldh1a1;abcc3 ZFP354A_10203;UGT2B10_33303,UGT2B1_33224;TRIB3_10079;SLCO1A2_9886;PF4_32963;ORM1_9400;NQO1_33055;NFE2L2_9301;LTBP1_33264;LPL_32544;INHBA_33300;IGFBP3_8881;GSTM2_8759;GSR_8755;GFPT1_8705;EGR1_8533;CYP1A1_8415;CCND1_8224;CAR3_8196;ASNS_8091;ALDH1A1_8022;ABCC3_7941 216.53733 80.56305 3.26713 315.7014129813468 226.73531026060985 316.72344911483594 123.97688713636363 47.0222 0.808077 177.5776125464382 129.49236096534213 176.19342858512192 710.2035068181817 128.205 6.6682 1372.1670724377277 725.2586826110173 1364.0694348937168 3.26713;25.4966;16.8949;440.994;179.631;56.9823;24.1117;6.6423;998.777;769.435;130.168;44.9033;3.28268;74.6342;981.5;8.26335;100.909;512.733;55.21;154.987;88.5069;86.4919 1.71987;11.3392;6.46469;299.351;110.795;16.0812;16.4151;3.4063;507.146;444.211;89.164;18.8755;0.808077;57.2867;554.87;1.51678;73.3629;330.024;24.6611;53.5946;65.9487;40.4498 6.6682;63.97775;58.9909;772.521;426.677;262.985;37.0434;13.4683;5065.92;2183.16;231.33;122.765;13.1174;106.529;4240.48;45.9052;159.385;1002.56;106.714;462.615;133.645;108.02 14 9 13 286954;246273;360918;24614;24314;83619;24424;116686;297417;24296;25612;24188;140668 UGT2B10_33303,UGT2B1_33224;TRIB3_10079;PF4_32963;ORM1_9400;NQO1_33055;NFE2L2_9301;GSTM2_8759;GSR_8755;GFPT1_8705;CYP1A1_8415;ASNS_8091;ALDH1A1_8022;ABCC3_7941 138.46696 74.6342 259.20812203831207 77.755559 40.4498 147.13700082518668 468.22567307692304 108.02 1142.8188488393764 25.4966;16.8949;179.631;56.9823;24.1117;6.6423;3.28268;74.6342;981.5;100.909;154.987;88.5069;86.4919 11.3392;6.46469;110.795;16.0812;16.4151;3.4063;0.808077;57.2867;554.87;73.3629;53.5946;65.9487;40.4498 63.97775;58.9909;426.677;262.985;37.0434;13.4683;13.1174;106.529;4240.48;159.385;462.615;133.645;108.02 9 24522;170698;59107;24539;29200;24484;24330;58919;54232 ZFP354A_10203;SLCO1A2_9886;LTBP1_33264;LPL_32544;INHBA_33300;IGFBP3_8881;EGR1_8533;CCND1_8224;CAR3_8196 329.3056422222222 130.168 369.63898165152943 190.74102777777776 89.164 204.48961292029554 1059.7270444444443 231.33 1658.5603714779902 3.26713;440.994;998.777;769.435;130.168;44.9033;8.26335;512.733;55.21 1.71987;299.351;507.146;444.211;89.164;18.8755;1.51678;330.024;24.6611 6.6682;772.521;5065.92;2183.16;231.33;122.765;45.9052;1002.56;106.714 0 Exp 2,4(0.18);Exp 4,9(0.4);Exp 5,2(0.09);Hill,2(0.09);Linear,1(0.05);Poly 2,5(0.22) 2.184147056730748 55.7215518951416 1.5232417583465576 6.495501518249512 1.346035419706213 1.7059084177017212 84.61410589188097 348.460554108119 49.77192569726914 198.18184857545816 136.8113813237053 1283.5956323126582 CONFLICT 0.5909090909090909 0.4090909090909091 0.0 GO:0001666 4 response to hypoxia 168 175 11 10 7 7 5 5 47 170 2325 0.85702 0.28432 0.40115 2.86 24522;83619;24484;24330;24296 zfp354a;nfe2l2;igfbp3;egr1;cyp1a1 ZFP354A_10203;NFE2L2_9301;IGFBP3_8881;EGR1_8533;CYP1A1_8415 32.797016 8.26335 3.26713 41.66469902782846 42.92758637058372 44.47750888224956 19.77627 3.4063 1.51678 30.82108359212408 26.6312201882004 33.65966726692344 69.63834 45.9052 6.6682 68.11842416591857 86.88723460321081 70.27034851290271 3.26713;6.6423;44.9033;8.26335;100.909 1.71987;3.4063;18.8755;1.51678;73.3629 6.6682;13.4683;122.765;45.9052;159.385 2 3 2 83619;24296 NFE2L2_9301;CYP1A1_8415 53.775650000000006 53.775650000000006 66.65662281007792 38.3846 38.3846 49.46678624875483 86.42665 86.42665 103.17868805836311 6.6423;100.909 3.4063;73.3629 13.4683;159.385 3 24522;24484;24330 ZFP354A_10203;IGFBP3_8881;EGR1_8533 18.81126 8.26335 22.734037632882114 7.370716666666667 1.71987 9.96395207973389 58.446133333333336 45.9052 59.055677112478634 3.26713;44.9033;8.26335 1.71987;18.8755;1.51678 6.6682;122.765;45.9052 0 Exp 4,3(0.6);Hill,1(0.2);Poly 2,1(0.2) 2.7837652817661924 16.888739824295044 1.5423688888549805 6.495501518249512 2.338754506592862 1.9061951637268066 -3.7237029210111956 69.3177349210112 -7.239600916459594 46.792140916459594 9.92990863357793 129.34677136642208 DOWN 0.4 0.6 0.0 GO:0046677 4 response to antibiotic 202 218 15 15 12 11 9 9 43 209 2286 0.98902 0.029698 0.038773 4.13 286954;24314;83619;116686;24330;24296;58919;54232;24188 ugt2b1;nqo1;nfe2l2;gsr;egr1;cyp1a1;ccnd1;car3;aldh1a1 UGT2B10_33303,UGT2B1_33224;NQO1_33055;NFE2L2_9301;GSR_8755;EGR1_8533;CYP1A1_8415;CCND1_8224;CAR3_8196;ALDH1A1_8022 99.61189444444443 55.21 6.6423 158.73355150412917 122.34020460958544 170.89146449813754 64.88453111111112 24.6611 1.51678 103.11343124353981 81.79962450906689 110.01328690338849 185.46973888888886 106.529 13.4683 310.0988260953955 224.19354386772866 336.469189755706 25.4966;24.1117;6.6423;74.6342;8.26335;100.909;512.733;55.21;88.5069 11.3392;16.4151;3.4063;57.2867;1.51678;73.3629;330.024;24.6611;65.9487 63.97775;37.0434;13.4683;106.529;45.9052;159.385;1002.56;106.714;133.645 7 3 6 286954;24314;83619;116686;24296;24188 UGT2B10_33303,UGT2B1_33224;NQO1_33055;NFE2L2_9301;GSR_8755;CYP1A1_8415;ALDH1A1_8022 53.38345 50.065400000000004 39.403491907634276 37.95981666666667 36.8509 30.909745651261296 85.67474166666666 85.253375 56.953990231786356 25.4966;24.1117;6.6423;74.6342;100.909;88.5069 11.3392;16.4151;3.4063;57.2867;73.3629;65.9487 63.97775;37.0434;13.4683;106.529;159.385;133.645 3 24330;58919;54232 EGR1_8533;CCND1_8224;CAR3_8196 192.0687833333333 55.21 278.6936523754906 118.73396000000001 24.6611 183.34809963418436 385.0597333333333 106.714 535.6345414920636 8.26335;512.733;55.21 1.51678;330.024;24.6611 45.9052;1002.56;106.714 0 Exp 2,1(0.1);Exp 4,4(0.4);Exp 5,1(0.1);Hill,1(0.1);Poly 2,3(0.3) 2.3460219279068704 25.983850479125977 1.5423688888549805 5.289852619171143 1.3638865822622113 1.933514654636383 -4.094025871586609 203.3178147604755 -2.4829106346682437 132.25197285689046 -17.128160826769516 388.06763860454726 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0042745 5 circadian sleep/wake cycle 2 2 1 1 1 1 1 1 51 1 2494 0.99959 0.040423 0.040423 50.0 316351 npas2 NPAS2_9350 134.458 134.458 134.458 134.458 56.7249 56.7249 56.7249 56.72489999999999 320.448 320.448 320.448 320.448 0.0 134.458 0.0 134.458 134.458 56.7249 320.448 0 1 0 1 316351 NPAS2_9350 134.458 134.458 56.7249 56.7249 320.448 320.448 134.458 56.7249 320.448 0 Hill,1(1) 1.8888624906539917 1.8888624906539917 1.8888624906539917 1.8888624906539917 0.0 1.8888624906539917 134.458 134.458 56.7249 56.7249 320.448 320.448 DOWN 0.0 1.0 0.0 GO:1903706 5 regulation of hemopoiesis 119 128 9 9 5 5 4 4 48 124 2371 0.88281 0.26362 0.33021 3.12 360918;83619;29200;25587 pf4;nfe2l2;inhba;id2 PF4_32963;NFE2L2_9301;INHBA_33300;ID2_8861 79.85951 68.40515 2.99674 88.98303140703702 62.83032794727332 80.01241644128075 51.090961 46.28515 0.998544 57.14661176073303 41.0751106601467 52.99211337307614 170.597325 122.39915 10.914 199.54410752284613 125.00758506431382 165.9464221749135 179.631;6.6423;130.168;2.99674 110.795;3.4063;89.164;0.998544 426.677;13.4683;231.33;10.914 3 1 3 360918;83619;25587 PF4_32963;NFE2L2_9301;ID2_8861 63.09001333333333 6.6423 100.94391366921799 38.399948 3.4063 62.70751141451009 150.3531 13.4683 239.3069250889535 179.631;6.6423;2.99674 110.795;3.4063;0.998544 426.677;13.4683;10.914 1 29200 INHBA_33300 130.168 130.168 89.164 89.164 231.33 231.33 130.168 89.164 231.33 0 Exp 4,1(0.25);Hill,1(0.25);Poly 2,2(0.5) 1.7453560289591212 7.015639901161194 1.5423688888549805 1.9777342081069946 0.2000172600453703 1.7477684020996094 -7.343860778896257 167.06288077889627 -4.912718525518379 107.09464052551837 -24.95590037238918 366.1505503723892 UP 0.75 0.25 0.0 GO:0006959 4 humoral immune response 62 73 2 2 2 2 2 2 50 71 2424 0.81456 0.44297 0.65999 2.74 360918;117517 pf4;c7 PF4_32963;C7_8179 96.73695000000001 96.73695000000001 13.8429 117.22988975003344 64.10130152923537 107.7621266892518 58.061930000000004 58.061930000000004 5.32886 74.57582277956979 37.30075431484258 68.55290301358401 234.28665 234.28665 41.8963 272.0810422397066 158.54196347826087 250.1071339919994 179.631;13.8429 110.795;5.32886 426.677;41.8963 1 1 1 360918 PF4_32963 179.631 179.631 110.795 110.795 426.677 426.677 179.631 110.795 426.677 1 117517 C7_8179 13.8429 13.8429 5.32886 5.32886 41.8963 41.8963 13.8429 5.32886 41.8963 0 Hill,1(0.5);Poly 2,1(0.5) 2.1395944178822672 4.321284770965576 1.8597915172576904 2.4614932537078857 0.42546737809565394 2.160642385482788 -65.73538799999997 259.209288 -45.29488719999999 161.41874719999998 -142.79843599999998 611.371736 CONFLICT 0.5 0.5 0.0 GO:0045595 5 regulation of cell differentiation 433 456 24 23 12 18 10 10 42 446 2049 0.67903 0.45732 0.85464 2.19 246273;360918;338475;83619;24539;29200;24484;25587;25695;58919 trib3;pf4;nrep;nfe2l2;lpl;inhba;igfbp3;id2;cebpd;ccnd1 TRIB3_10079;PF4_32963;NREP_9364;NFE2L2_9301;LPL_32544;INHBA_33300;IGFBP3_8881;ID2_8861;CEBPD_8283;CCND1_8224 178.16885899999997 78.76365 2.99674 258.57858879744884 250.18386989282067 312.52334195674223 108.5558884 49.1687 0.998544 154.68632128764327 150.08544417561563 185.30401702217804 425.85542 157.552 10.914 687.141088409468 622.1034328606877 854.9634754757159 16.8949;179.631;112.624;6.6423;769.435;130.168;44.9033;2.99674;5.66035;512.733 6.46469;110.795;79.4619;3.4063;444.211;89.164;18.8755;0.998544;2.15795;330.024 58.9909;426.677;192.339;13.4683;2183.16;231.33;122.765;10.914;16.35;1002.56 4 6 4 246273;360918;83619;25587 TRIB3_10079;PF4_32963;NFE2L2_9301;ID2_8861 51.541235 11.7686 85.59563615361611 30.4161335 4.9354949999999995 53.632575621061825 127.51255 36.229600000000005 200.66215178975995 16.8949;179.631;6.6423;2.99674 6.46469;110.795;3.4063;0.998544 58.9909;426.677;13.4683;10.914 6 338475;24539;29200;24484;25695;58919 NREP_9364;LPL_32544;INHBA_33300;IGFBP3_8881;CEBPD_8283;CCND1_8224 262.587275 121.396 307.5350731462864 160.64905833333333 84.31295 182.2173905711209 624.7506666666667 211.8345 840.8662430783307 112.624;769.435;130.168;44.9033;5.66035;512.733 79.4619;444.211;89.164;18.8755;2.15795;330.024 192.339;2183.16;231.33;122.765;16.35;1002.56 0 Exp 2,2(0.2);Exp 4,4(0.4);Hill,1(0.1);Poly 2,3(0.3) 1.7464153509736668 17.5890074968338 1.5423688888549805 2.2692105770111084 0.2296976191901613 1.672523558139801 17.900189228600595 338.4375287713994 12.680313164257626 204.4314636357424 -0.03903899916491582 851.749878999165 DOWN 0.4 0.6 0.0 GO:0071702 5 organic substance transport 316 335 14 13 7 9 6 6 46 329 2166 0.46364 0.6982 1.0 1.79 170698;266730;29200;25598;114628;140668 slco1a2;slc17a3;inhba;fabp2;abcg5;abcc3 SLCO1A2_9886;SLC17A3_9840;INHBA_33300;FABP2_32859;ABCG5_7947;ABCC3_7941 204.00426666666667 138.4065 58.7587 157.76505189114187 199.43706804185607 157.48566520991648 140.85515 92.50880000000001 40.4498 115.24291636375312 138.3322309260371 118.12381809380273 339.81488333333334 275.4325 78.8953 267.15464190727 320.9136748005832 262.7229611423473 440.994;58.7587;130.168;146.645;360.968;86.4919 299.351;46.6655;89.164;95.8536;273.647;40.4498 772.521;78.8953;231.33;319.535;528.588;108.02 3 3 3 266730;25598;140668 SLC17A3_9840;FABP2_32859;ABCC3_7941 97.29853333333334 86.4919 44.928698233126376 60.98963333333334 46.6655 30.352608791063272 168.81676666666667 108.02 131.33564417881132 58.7587;146.645;86.4919 46.6655;95.8536;40.4498 78.8953;319.535;108.02 3 170698;29200;114628 SLCO1A2_9886;INHBA_33300;ABCG5_7947 310.71000000000004 360.968 161.39269033013846 220.7206666666667 273.647 114.65400696152459 510.81299999999993 528.588 271.033000922397 440.994;130.168;360.968 299.351;89.164;273.647 772.521;231.33;528.588 0 Exp 2,1(0.17);Exp 5,1(0.17);Linear,1(0.17);Poly 2,3(0.5) 2.050883799058907 12.714155077934265 1.6357452869415283 3.368933916091919 0.6483418846056672 1.9424351453781128 77.76593371684416 330.2425996164892 48.64161175659858 233.06868824340143 126.04664867100155 553.5831179956651 CONFLICT 0.5 0.5 0.0 GO:0051054 7 positive regulation of DNA metabolic process 56 60 4 3 3 2 2 2 50 58 2437 0.87792 0.34809 0.34809 3.33 316351;24484 npas2;igfbp3 NPAS2_9350;IGFBP3_8881 89.68065 89.68065 44.9033 63.3247356571269 86.82034390355389 63.19540682766641 37.8002 37.8002 18.8755 26.76356740384211 36.591320180550795 26.708907865059867 221.60649999999998 221.60649999999998 122.765 139.78298982530032 215.2926617529425 139.49750943181746 134.458;44.9033 56.7249;18.8755 320.448;122.765 0 2 0 2 316351;24484 NPAS2_9350;IGFBP3_8881 89.68065 89.68065 63.3247356571269 37.8002 37.8002 26.76356740384211 221.60649999999998 221.60649999999998 139.78298982530032 134.458;44.9033 56.7249;18.8755 320.448;122.765 0 Exp 4,1(0.5);Hill,1(0.5) 1.767973561379817 3.5436841249465942 1.6548216342926025 1.8888624906539917 0.165491876607845 1.7718420624732971 1.9170440000000042 177.444256 0.7077880000000007 74.89261199999999 27.877160000000032 415.33583999999996 DOWN 0.0 1.0 0.0 GO:0008150 1 biological_process 2293 2547 123 114 65 92 52 52 0 2495 0 1.0 1.0 1.0 2.04 24522;286954;308843;246273;24902;305291;170698;266730;299270;501907;363140;360918;24614;338475;24314;316351;83619;25333;307126;59107;24539;29200;24484;494344;25587;24424;300850;116686;297417;289388;246248;25598;25315;24330;499353;29277;24296;29276;290277;289185;25695;58919;54232;117517;25612;64392;24188;26760;24763;114628;140668;296925 zfp354a;ugt2b1;tsku;trib3;sult2a6;srd5a3;slco1a2;slc17a3;serpina6;rgd1559459;rassf1;pf4;orm1;nrep;nqo1;npas2;nfe2l2;mgp;mcm10;ltbp1;lpl;inhba;igfbp3;ier2;id2;gstm2;gsta4;gsr;gfpt1;g0s2;fmo5;fabp2;ephx1;egr1;cyp2c24;cyp2c11;cyp1a1;csrp1;cryl1;creg1;cebpd;ccnd1;car3;c7;asns;aldh1l1;aldh1a1;akr7a3;acsm3;abcg5;abcc3;aass ZFP354A_10203;UGT2B10_33303,UGT2B1_33224;TSKU_10094;TRIB3_10079;SULT2A6_32471,SULT2A6_9972;SRD5A3_9939;SLCO1A2_9886;SLC17A3_9840;SERPINA6_32325;RGD1559459_9690;RASSF1_32475;PF4_32963;ORM1_9400;NREP_9364;NQO1_33055;NPAS2_9350;NFE2L2_9301;MGP_33209;MCM10_32579;LTBP1_33264;LPL_32544;INHBA_33300;IGFBP3_8881;IER2_32643;ID2_8861;GSTM2_8759;GSTA4_8757;GSR_8755;GFPT1_8705;G0S2_32729;FMO5_33281;FABP2_32859;EPHX1_8567;EGR1_8533;CYP2C24_32875;CYP2C11_32593;CYP1A1_8415;CSRP1_8396;CRYL1_8388;CREG1_8380;CEBPD_8283;CCND1_8224;CAR3_8196;C7_8179;ASNS_8091;ALDH1L1_32662;ALDH1A1_8022;AKR7A3_8015;ACSM3_7976;ABCG5_7947;ABCC3_7941;AASS_7936 187.77644230769232 81.261 2.99674 258.2412553576196 215.85096343556933 273.10799666726524 112.4171015576923 45.98805 0.808077 154.68956689004833 128.85275488266177 162.59604355259447 507.1559567307693 156.873 6.6682 950.4960734305027 553.2730900274919 954.3126559716192 3.26713;25.4966;6.12626;16.8949;50.527550000000005;169.209;440.994;58.7587;15.8474;42.78;756.581;179.631;56.9823;112.624;24.1117;134.458;6.6423;75.1005;213.608;998.777;769.435;130.168;44.9033;543.54;2.99674;3.28268;105.355;74.6342;981.5;3.45084;57.4978;146.645;24.8784;8.26335;733.935;129.934;100.909;373.299;76.0301;94.3216;5.66035;512.733;55.21;13.8429;154.987;184.03;88.5069;19.8501;460.125;360.968;86.4919;28.5735 1.71987;11.3392;1.46625;6.46469;20.8664;105.547;299.351;46.6655;7.7531;20.6065;437.5;110.795;16.0812;79.4619;16.4151;56.7249;3.4063;13.9312;123.177;507.146;444.211;89.164;18.8755;375.947;0.998544;0.808077;75.6422;57.2867;554.87;1.07374;31.5489;95.8536;15.4867;1.51678;463.206;45.3106;73.3629;263.875;23.2788;69.2457;2.15795;330.024;24.6611;5.32886;53.5946;111.154;65.9487;12.797;331.8;273.647;40.4498;6.14642 6.6682;63.97775;41.3339;58.9909;154.361;459.211;772.521;78.8953;40.8362;93.6128;940.187;426.677;262.985;192.339;37.0434;320.448;13.4683;346.231;668.095;5065.92;2183.16;231.33;122.765;978.946;10.914;13.1174;172.041;106.529;4240.48;14.3222;109.026;319.535;41.3795;45.9052;1763.75;355.143;159.385;603.145;250.463;147.421;16.35;1002.56;106.714;41.8963;462.615;1150.07;133.645;32.3544;748.659;528.588;108.02;128.079 30 24 28 286954;246273;24902;305291;266730;501907;363140;360918;24614;24314;83619;25587;24424;300850;116686;297417;289388;246248;25598;25315;24296;290277;289185;25612;64392;24188;26760;140668 UGT2B10_33303,UGT2B1_33224;TRIB3_10079;SULT2A6_32471,SULT2A6_9972;SRD5A3_9939;SLC17A3_9840;RGD1559459_9690;RASSF1_32475;PF4_32963;ORM1_9400;NQO1_33055;NFE2L2_9301;ID2_8861;GSTM2_8759;GSTA4_8757;GSR_8755;GFPT1_8705;G0S2_32729;FMO5_33281;FABP2_32859;EPHX1_8567;CYP1A1_8415;CRYL1_8388;CREG1_8380;ASNS_8091;ALDH1L1_32662;ALDH1A1_8022;AKR7A3_8015;ABCC3_7941 128.3207967857143 66.69645 218.4823785360437 74.25310182142857 35.99935 125.25483800256318 359.3116767857142 121.3355 807.258251618098 25.4966;16.8949;50.527550000000005;169.209;58.7587;42.78;756.581;179.631;56.9823;24.1117;6.6423;2.99674;3.28268;105.355;74.6342;981.5;3.45084;57.4978;146.645;24.8784;100.909;76.0301;94.3216;154.987;184.03;88.5069;19.8501;86.4919 11.3392;6.46469;20.8664;105.547;46.6655;20.6065;437.5;110.795;16.0812;16.4151;3.4063;0.998544;0.808077;75.6422;57.2867;554.87;1.07374;31.5489;95.8536;15.4867;73.3629;23.2788;69.2457;53.5946;111.154;65.9487;12.797;40.4498 63.97775;58.9909;154.361;459.211;78.8953;93.6128;940.187;426.677;262.985;37.0434;13.4683;10.914;13.1174;172.041;106.529;4240.48;14.3222;109.026;319.535;41.3795;159.385;250.463;147.421;462.615;1150.07;133.645;32.3544;108.02 24 24522;308843;170698;299270;338475;316351;25333;307126;59107;24539;29200;24484;494344;24330;499353;29277;29276;25695;58919;54232;117517;24763;114628;296925 ZFP354A_10203;TSKU_10094;SLCO1A2_9886;SERPINA6_32325;NREP_9364;NPAS2_9350;MGP_33209;MCM10_32579;LTBP1_33264;LPL_32544;INHBA_33300;IGFBP3_8881;IER2_32643;EGR1_8533;CYP2C24_32875;CYP2C11_32593;CSRP1_8396;CEBPD_8283;CCND1_8224;CAR3_8196;C7_8179;ACSM3_7976;ABCG5_7947;AASS_7936 257.14136208333326 130.051 287.2529505971896 156.9417679166667 68.0934 175.50109759404623 679.64095 333.3395 1086.5692990039988 3.26713;6.12626;440.994;15.8474;112.624;134.458;75.1005;213.608;998.777;769.435;130.168;44.9033;543.54;8.26335;733.935;129.934;373.299;5.66035;512.733;55.21;13.8429;460.125;360.968;28.5735 1.71987;1.46625;299.351;7.7531;79.4619;56.7249;13.9312;123.177;507.146;444.211;89.164;18.8755;375.947;1.51678;463.206;45.3106;263.875;2.15795;330.024;24.6611;5.32886;331.8;273.647;6.14642 6.6682;41.3339;772.521;40.8362;192.339;320.448;346.231;668.095;5065.92;2183.16;231.33;122.765;978.946;45.9052;1763.75;355.143;603.145;16.35;1002.56;106.714;41.8963;748.659;528.588;128.079 0 Exp 2,5(0.1);Exp 4,18(0.34);Exp 5,3(0.06);Hill,9(0.17);Linear,5(0.1);Poly 2,14(0.26) 2.046188183987364 117.44047915935516 1.5232417583465576 6.495501518249512 0.9638085047961368 1.8453741073608398 117.585669547735 257.9672150676497 70.3719983348186 154.46220478056603 248.8081810935966 765.5037323679421 CONFLICT 0.5384615384615384 0.46153846153846156 0.0 GO:0051171 5 regulation of nitrogen compound metabolic process 917 985 46 42 20 30 15 15 37 970 1525 0.090713 0.94911 0.1525 1.52 24522;246273;299270;363140;360918;316351;83619;29200;24484;494344;25587;24330;289185;25695;58919 zfp354a;trib3;serpina6;rassf1;pf4;npas2;nfe2l2;inhba;igfbp3;ier2;id2;egr1;creg1;cebpd;ccnd1 ZFP354A_10203;TRIB3_10079;SERPINA6_32325;RASSF1_32475;PF4_32963;NPAS2_9350;NFE2L2_9301;INHBA_33300;IGFBP3_8881;IER2_32643;ID2_8861;EGR1_8533;CREG1_8380;CEBPD_8283;CCND1_8224 163.72720466666667 44.9033 2.99674 240.17110135179982 210.94612251797176 281.60211088169825 100.8195556 18.8755 0.998544 150.690939687075 125.89418952024913 172.11504968712597 290.89778666666666 122.765 6.6682 374.2626694451502 348.8609717760523 405.98281743202284 3.26713;16.8949;15.8474;756.581;179.631;134.458;6.6423;130.168;44.9033;543.54;2.99674;8.26335;94.3216;5.66035;512.733 1.71987;6.46469;7.7531;437.5;110.795;56.7249;3.4063;89.164;18.8755;375.947;0.998544;1.51678;69.2457;2.15795;330.024 6.6682;58.9909;40.8362;940.187;426.677;320.448;13.4683;231.33;122.765;978.946;10.914;45.9052;147.421;16.35;1002.56 6 9 6 246273;363140;360918;83619;25587;289185 TRIB3_10079;RASSF1_32475;PF4_32963;NFE2L2_9301;ID2_8861;CREG1_8380 176.17792333333333 55.60825 292.46717565368334 104.73503899999999 37.855195 168.9464831324446 266.27636666666666 103.20595 364.99304778351416 16.8949;756.581;179.631;6.6423;2.99674;94.3216 6.46469;437.5;110.795;3.4063;0.998544;69.2457 58.9909;940.187;426.677;13.4683;10.914;147.421 9 24522;299270;316351;29200;24484;494344;24330;25695;58919 ZFP354A_10203;SERPINA6_32325;NPAS2_9350;INHBA_33300;IGFBP3_8881;IER2_32643;EGR1_8533;CEBPD_8283;CCND1_8224 155.42672555555555 44.9033 217.4611352679295 98.20923333333333 18.8755 147.91921331260852 307.3120666666666 122.765 401.3810335085727 3.26713;15.8474;134.458;130.168;44.9033;543.54;8.26335;5.66035;512.733 1.71987;7.7531;56.7249;89.164;18.8755;375.947;1.51678;2.15795;330.024 6.6682;40.8362;320.448;231.33;122.765;978.946;45.9052;16.35;1002.56 0 Exp 2,1(0.07);Exp 4,6(0.4);Hill,3(0.2);Linear,1(0.07);Poly 2,4(0.27) 2.0902337231523065 35.156686186790466 1.5423688888549805 6.495501518249512 1.475698754044153 1.8309566974639893 42.18385769862695 285.2705516347064 24.55941828856801 177.079692911432 101.49474344655542 480.30082988677793 DOWN 0.4 0.6 0.0 GO:0048523 5 negative regulation of cellular process 938 999 48 46 26 33 20 20 32 979 1516 0.51589 0.59767 1.0 2.0 24522;308843;246273;299270;363140;360918;24314;316351;83619;59107;24539;29200;24484;25587;24424;297417;24330;25695;58919;25612 zfp354a;tsku;trib3;serpina6;rassf1;pf4;nqo1;npas2;nfe2l2;ltbp1;lpl;inhba;igfbp3;id2;gstm2;gfpt1;egr1;cebpd;ccnd1;asns ZFP354A_10203;TSKU_10094;TRIB3_10079;SERPINA6_32325;RASSF1_32475;PF4_32963;NQO1_33055;NPAS2_9350;NFE2L2_9301;LTBP1_33264;LPL_32544;INHBA_33300;IGFBP3_8881;ID2_8861;GSTM2_8759;GFPT1_8705;EGR1_8533;CEBPD_8283;CCND1_8224;ASNS_8091 237.8133055 34.5075 2.99674 351.82173484885425 305.0600025604845 372.54430697229304 132.28058305 17.6453 0.808077 197.3280783467999 169.5662444715614 208.8555769530152 764.0384750000001 90.87795 6.6682 1436.4401080905648 889.3063601785051 1461.286970187698 3.26713;6.12626;16.8949;15.8474;756.581;179.631;24.1117;134.458;6.6423;998.777;769.435;130.168;44.9033;2.99674;3.28268;981.5;8.26335;5.66035;512.733;154.987 1.71987;1.46625;6.46469;7.7531;437.5;110.795;16.4151;56.7249;3.4063;507.146;444.211;89.164;18.8755;0.998544;0.808077;554.87;1.51678;2.15795;330.024;53.5946 6.6682;41.3339;58.9909;40.8362;940.187;426.677;37.0434;320.448;13.4683;5065.92;2183.16;231.33;122.765;10.914;13.1174;4240.48;45.9052;16.35;1002.56;462.615 9 11 9 246273;363140;360918;24314;83619;25587;24424;297417;25612 TRIB3_10079;RASSF1_32475;PF4_32963;NQO1_33055;NFE2L2_9301;ID2_8861;GSTM2_8759;GFPT1_8705;ASNS_8091 236.29192444444445 24.1117 369.2003440177955 131.6502567777778 16.4151 211.77029707041086 689.2769999999999 58.9909 1368.8995488079108 16.8949;756.581;179.631;24.1117;6.6423;2.99674;3.28268;981.5;154.987 6.46469;437.5;110.795;16.4151;3.4063;0.998544;0.808077;554.87;53.5946 58.9909;940.187;426.677;37.0434;13.4683;10.914;13.1174;4240.48;462.615 11 24522;308843;299270;316351;59107;24539;29200;24484;24330;25695;58919 ZFP354A_10203;TSKU_10094;SERPINA6_32325;NPAS2_9350;LTBP1_33264;LPL_32544;INHBA_33300;IGFBP3_8881;EGR1_8533;CEBPD_8283;CCND1_8224 239.05807181818182 44.9033 355.14547746920874 132.79630454545455 18.8755 195.20483302170058 825.2069545454546 122.765 1553.1031770489335 3.26713;6.12626;15.8474;134.458;998.777;769.435;130.168;44.9033;8.26335;5.66035;512.733 1.71987;1.46625;7.7531;56.7249;507.146;444.211;89.164;18.8755;1.51678;2.15795;330.024 6.6682;41.3339;40.8362;320.448;5065.92;2183.16;231.33;122.765;45.9052;16.35;1002.56 0 Exp 2,3(0.15);Exp 4,8(0.4);Hill,5(0.25);Linear,1(0.05);Poly 2,3(0.15) 2.1566564083122164 48.089696288108826 1.5232417583465576 6.495501518249512 1.4056732921906252 1.8364248275756836 83.62063174354688 392.0059792564532 45.797739627641604 218.7634264723584 134.4908404496607 1393.5861095503392 CONFLICT 0.45 0.55 0.0 GO:0006810 4 transport 570 605 16 15 8 11 7 7 45 598 1897 0.049129 0.97878 0.098198 1.16 170698;266730;29200;25598;58919;114628;140668 slco1a2;slc17a3;inhba;fabp2;ccnd1;abcg5;abcc3 SLCO1A2_9886;SLC17A3_9840;INHBA_33300;FABP2_32859;CCND1_8224;ABCG5_7947;ABCC3_7941 248.10837142857142 146.645 58.7587 185.35833961039467 248.94176213620278 188.51541386276696 167.87927142857143 95.8536 40.4498 127.1989129261294 168.62193921908477 130.86530779686402 434.49275714285716 319.535 78.8953 349.604968644344 428.62235968079733 358.6412153766262 440.994;58.7587;130.168;146.645;512.733;360.968;86.4919 299.351;46.6655;89.164;95.8536;330.024;273.647;40.4498 772.521;78.8953;231.33;319.535;1002.56;528.588;108.02 3 4 3 266730;25598;140668 SLC17A3_9840;FABP2_32859;ABCC3_7941 97.29853333333334 86.4919 44.928698233126376 60.98963333333334 46.6655 30.352608791063272 168.81676666666667 108.02 131.33564417881132 58.7587;146.645;86.4919 46.6655;95.8536;40.4498 78.8953;319.535;108.02 4 170698;29200;58919;114628 SLCO1A2_9886;INHBA_33300;CCND1_8224;ABCG5_7947 361.21575 400.981 166.0373154652792 248.0465 286.499 108.39971807005153 633.74975 650.5545 330.7965684952763 440.994;130.168;512.733;360.968 299.351;89.164;330.024;273.647 772.521;231.33;1002.56;528.588 0 Exp 2,2(0.29);Exp 5,1(0.15);Linear,1(0.15);Poly 2,3(0.43) 1.97145479527101 14.26962435245514 1.555469274520874 3.368933916091919 0.62901525521691 1.7953243255615234 110.7929918171034 385.4237510400394 73.64899804928815 262.1095448078548 175.50177198212594 693.4837423035883 CONFLICT 0.42857142857142855 0.5714285714285714 0.0 GO:0071496 4 cellular response to external stimulus 143 149 12 12 5 10 5 5 47 144 2351 0.92004 0.18498 0.22709 3.36 83619;59107;24539;24330;25612 nfe2l2;ltbp1;lpl;egr1;asns NFE2L2_9301;LTBP1_33264;LPL_32544;EGR1_8533;ASNS_8091 387.62093 154.987 6.6423 464.3460889668362 532.6872169681044 467.980138967812 201.974936 53.5946 1.51678 251.7128267621646 284.86584577600576 253.45006965477057 1554.2136999999998 462.615 13.4683 2154.5378406040168 2107.3291584305907 2213.204922867457 6.6423;998.777;769.435;8.26335;154.987 3.4063;507.146;444.211;1.51678;53.5946 13.4683;5065.92;2183.16;45.9052;462.615 2 3 2 83619;25612 NFE2L2_9301;ASNS_8091 80.81465 80.81465 104.89554332308404 28.50045 28.50045 35.4884872662248 238.04165 238.04165 317.5946773175599 6.6423;154.987 3.4063;53.5946 13.4683;462.615 3 59107;24539;24330 LTBP1_33264;LPL_32544;EGR1_8533 592.15845 769.435 518.5070434372203 317.62459333333334 444.211 275.5600039810497 2431.6617333333334 2183.16 2519.216541239957 998.777;769.435;8.26335 507.146;444.211;1.51678 5065.92;2183.16;45.9052 0 Exp 2,2(0.4);Exp 4,2(0.4);Hill,1(0.2) 2.2654655656136766 12.799343824386597 1.5423688888549805 5.289852619171143 1.5883193435226126 1.6902254819869995 -19.396362646276202 794.6382226462763 -18.66108464794067 422.6109566479407 -334.3219841009857 3442.7493841009855 DOWN 0.4 0.6 0.0 GO:0010243 5 response to organonitrogen compound 400 420 31 28 16 20 12 12 40 408 2087 0.92575 0.13582 0.189 2.86 24522;286954;246273;24614;83619;24484;24424;297417;24330;58919;25612;140668 zfp354a;ugt2b1;trib3;orm1;nfe2l2;igfbp3;gstm2;gfpt1;egr1;ccnd1;asns;abcc3 ZFP354A_10203;UGT2B10_33303,UGT2B1_33224;TRIB3_10079;ORM1_9400;NFE2L2_9301;IGFBP3_8881;GSTM2_8759;GFPT1_8705;EGR1_8533;CCND1_8224;ASNS_8091;ABCC3_7941 158.45370499999999 35.19995 3.26713 295.84715572181517 110.283122318996 196.4891980884623 86.59583475 13.7102 0.808077 173.7610259162769 59.87537374996492 122.75480837070225 533.4627291666666 85.998875 6.6682 1201.9604814823995 286.6972821661069 619.6070192294852 3.26713;25.4966;16.8949;56.9823;6.6423;44.9033;3.28268;981.5;8.26335;512.733;154.987;86.4919 1.71987;11.3392;6.46469;16.0812;3.4063;18.8755;0.808077;554.87;1.51678;330.024;53.5946;40.4498 6.6682;63.97775;58.9909;262.985;13.4683;122.765;13.1174;4240.48;45.9052;1002.56;462.615;108.02 9 4 8 286954;246273;24614;83619;24424;297417;25612;140668 UGT2B10_33303,UGT2B1_33224;TRIB3_10079;ORM1_9400;NFE2L2_9301;GSTM2_8759;GFPT1_8705;ASNS_8091;ABCC3_7941 166.53471000000002 41.239450000000005 333.2118555523475 85.876733375 13.7102 190.42509146752892 652.95679375 85.998875 1457.6702862190396 25.4966;16.8949;56.9823;6.6423;3.28268;981.5;154.987;86.4919 11.3392;6.46469;16.0812;3.4063;0.808077;554.87;53.5946;40.4498 63.97775;58.9909;262.985;13.4683;13.1174;4240.48;462.615;108.02 4 24522;24484;24330;58919 ZFP354A_10203;IGFBP3_8881;EGR1_8533;CCND1_8224 142.29169499999998 26.583325000000002 247.65748314130497 88.0340375 10.297685 161.53164459472504 294.4746 84.3351 474.51322107420077 3.26713;44.9033;8.26335;512.733 1.71987;18.8755;1.51678;330.024 6.6682;122.765;45.9052;1002.56 0 Exp 2,1(0.08);Exp 4,8(0.62);Exp 5,1(0.08);Hill,2(0.16);Linear,1(0.08) 2.2247911636906346 33.0254385471344 1.5232417583465576 6.495501518249512 1.6014649979190532 1.7026138305664062 -8.937581295075631 325.84499129507566 -11.718720835679477 184.91039033567947 -146.61043422170576 1213.535892555039 UP 0.6666666666666666 0.3333333333333333 0.0 GO:1901575 4 organic substance catabolic process 296 332 25 24 10 17 8 8 44 324 2171 0.77065 0.36506 0.53737 2.41 286954;305291;83619;24539;24296;64392;26760;296925 ugt2b1;srd5a3;nfe2l2;lpl;cyp1a1;aldh1l1;akr7a3;aass UGT2B10_33303,UGT2B1_33224;SRD5A3_9939;NFE2L2_9301;LPL_32544;CYP1A1_8415;ALDH1L1_32662;AKR7A3_8015;AASS_7936 163.0181875 64.74125000000001 6.6423 254.67536887289856 203.81790806761944 294.1333816722775 95.99547749999999 43.07995 3.4063 147.7553851873003 120.32299004558035 169.79898022352094 523.7131812499999 143.732 13.4683 770.2178287959795 587.199042368635 857.7786489276612 25.4966;169.209;6.6423;769.435;100.909;184.03;19.8501;28.5735 11.3392;105.547;3.4063;444.211;73.3629;111.154;12.797;6.14642 63.97775;459.211;13.4683;2183.16;159.385;1150.07;32.3544;128.079 7 2 6 286954;305291;83619;24296;64392;26760 UGT2B10_33303,UGT2B1_33224;SRD5A3_9939;NFE2L2_9301;CYP1A1_8415;ALDH1L1_32662;AKR7A3_8015 84.35616666666668 63.2028 78.83374780472298 52.934400000000004 43.07995 49.73758206141509 313.07774166666667 111.681375 441.8494418877797 25.4966;169.209;6.6423;100.909;184.03;19.8501 11.3392;105.547;3.4063;73.3629;111.154;12.797 63.97775;459.211;13.4683;159.385;1150.07;32.3544 2 24539;296925 LPL_32544;AASS_7936 399.00424999999996 399.00424999999996 523.8681905700373 225.17871 225.17871 309.7584351156369 1155.6195 1155.6195 1453.1617109876308 769.435;28.5735 444.211;6.14642 2183.16;128.079 0 Exp 2,1(0.12);Exp 4,4(0.45);Hill,1(0.12);Poly 2,3(0.34) 1.8537968987723552 17.57249128818512 1.5321133136749268 4.1214375495910645 0.8212629128515162 1.6986740827560425 -13.462839224587754 339.4992142245877 -6.393780626314992 198.384735626315 -10.020543487768123 1057.4469059877679 UP 0.75 0.25 0.0 GO:0045347 8 negative regulation of MHC class II biosynthetic process 2 2 1 1 1 1 1 1 51 1 2494 0.99959 0.040423 0.040423 50.0 360918 pf4 PF4_32963 179.631 179.631 179.631 179.631 110.795 110.795 110.795 110.795 426.677 426.677 426.677 426.67699999999996 0.0 179.631 0.0 179.631 179.631 110.795 426.677 1 0 1 360918 PF4_32963 179.631 179.631 110.795 110.795 426.677 426.677 179.631 110.795 426.677 0 0 Poly 2,1(1) 1.8597915172576904 1.8597915172576904 1.8597915172576904 1.8597915172576904 0.0 1.8597915172576904 179.631 179.631 110.795 110.795 426.677 426.677 UP 1.0 0.0 0.0 GO:0031103 7 axon regeneration 17 18 2 2 1 2 1 1 51 17 2478 0.94922 0.31103 0.31103 5.56 338475 nrep NREP_9364 112.624 112.624 112.624 112.624 79.4619 79.4619 79.4619 79.4619 192.339 192.339 192.339 192.339 0.0 112.624 112.624 79.4619 192.339 0 1 0 1 338475 NREP_9364 112.624 112.624 79.4619 79.4619 192.339 192.339 112.624 79.4619 192.339 0 Poly 2,1(1) 1.826043963432312 1.826043963432312 1.826043963432312 1.826043963432312 0.0 1.826043963432312 112.624 112.624 79.4619 79.4619 192.339 192.339 DOWN 0.0 1.0 0.0 GO:0033273 5 response to vitamin 73 78 7 7 6 7 6 6 46 72 2423 0.99915 0.0045026 0.0045026 7.69 24522;24614;59107;116686;24296;58919 zfp354a;orm1;ltbp1;gsr;cyp1a1;ccnd1 ZFP354A_10203;ORM1_9400;LTBP1_33264;GSR_8755;CYP1A1_8415;CCND1_8224 291.217105 87.7716 3.26713 392.58547051384386 270.9127709188774 383.3505570882112 164.27011166666668 65.3248 1.71987 206.46081100764962 152.16123957067794 201.50103834682398 1100.6745333333333 211.185 6.6682 1975.1315404909585 1031.249392161135 1927.7428800080977 2.5 87.7716 3.26713;56.9823;998.777;74.6342;100.909;512.733 1.71987;16.0812;507.146;57.2867;73.3629;330.024 6.6682;262.985;5065.92;106.529;159.385;1002.56 3 3 3 24614;116686;24296 ORM1_9400;GSR_8755;CYP1A1_8415 77.50850000000001 74.6342 22.103957645408208 48.910266666666665 57.2867 29.545249453394938 176.29966666666667 159.385 79.58768400533677 56.9823;74.6342;100.909 16.0812;57.2867;73.3629 262.985;106.529;159.385 3 24522;59107;58919 ZFP354A_10203;LTBP1_33264;CCND1_8224 504.92571 512.733 497.8008544083792 279.62995666666666 330.024 256.453822206466 2025.0493999999999 1002.56 2680.134441363918 3.26713;998.777;512.733 1.71987;507.146;330.024 6.6682;5065.92;1002.56 0 Exp 2,2(0.34);Exp 4,2(0.34);Poly 2,2(0.34) 2.1483220423883895 15.145433187484741 1.555469274520874 6.495501518249512 1.9528764146271893 1.7744695544242859 -22.916695508527027 605.3509055085269 -0.9329436909784761 329.4731670243118 -479.7598533661792 2681.108920032846 CONFLICT 0.5 0.5 0.0 GO:0080090 5 regulation of primary metabolic process 955 1029 50 46 22 34 17 17 35 1012 1483 0.15822 0.90229 0.31756 1.65 24522;246273;299270;363140;360918;316351;83619;29200;24484;494344;25587;297417;246248;24330;289185;25695;58919 zfp354a;trib3;serpina6;rassf1;pf4;npas2;nfe2l2;inhba;igfbp3;ier2;id2;gfpt1;fmo5;egr1;creg1;cebpd;ccnd1 ZFP354A_10203;TRIB3_10079;SERPINA6_32325;RASSF1_32475;PF4_32963;NPAS2_9350;NFE2L2_9301;INHBA_33300;IGFBP3_8881;IER2_32643;ID2_8861;GFPT1_8705;FMO5_33281;EGR1_8533;CREG1_8380;CEBPD_8283;CCND1_8224 205.58269823529412 57.4978 2.99674 301.84901465123994 215.14107235029394 289.5006772597497 123.45366082352942 31.5489 0.998544 180.30524704863976 127.88386952434837 175.46328279592996 512.5278117647058 122.765 6.6682 1023.421189277752 390.78920444695905 606.0254590414917 3.26713;16.8949;15.8474;756.581;179.631;134.458;6.6423;130.168;44.9033;543.54;2.99674;981.5;57.4978;8.26335;94.3216;5.66035;512.733 1.71987;6.46469;7.7531;437.5;110.795;56.7249;3.4063;89.164;18.8755;375.947;0.998544;554.87;31.5489;1.51678;69.2457;2.15795;330.024 6.6682;58.9909;40.8362;940.187;426.677;320.448;13.4683;231.33;122.765;978.946;10.914;4240.48;109.026;45.9052;147.421;16.35;1002.56 8 9 8 246273;363140;360918;83619;25587;297417;246248;289185 TRIB3_10079;RASSF1_32475;PF4_32963;NFE2L2_9301;ID2_8861;GFPT1_8705;FMO5_33281;CREG1_8380 262.0081675 75.9097 383.8487828197943 151.85364175 50.3973 218.08614388074375 743.3955249999999 128.2235 1447.3611599675603 16.8949;756.581;179.631;6.6423;2.99674;981.5;57.4978;94.3216 6.46469;437.5;110.795;3.4063;0.998544;554.87;31.5489;69.2457 58.9909;940.187;426.677;13.4683;10.914;4240.48;109.026;147.421 9 24522;299270;316351;29200;24484;494344;24330;25695;58919 ZFP354A_10203;SERPINA6_32325;NPAS2_9350;INHBA_33300;IGFBP3_8881;IER2_32643;EGR1_8533;CEBPD_8283;CCND1_8224 155.42672555555555 44.9033 217.4611352679295 98.20923333333333 18.8755 147.91921331260852 307.3120666666666 122.765 401.3810335085727 3.26713;15.8474;134.458;130.168;44.9033;543.54;8.26335;5.66035;512.733 1.71987;7.7531;56.7249;89.164;18.8755;375.947;1.51678;2.15795;330.024 6.6682;40.8362;320.448;231.33;122.765;978.946;45.9052;16.35;1002.56 0 Exp 2,1(0.06);Exp 4,6(0.36);Exp 5,1(0.06);Hill,3(0.18);Linear,2(0.12);Poly 2,4(0.24) 2.0255707819632307 38.361109495162964 1.5232417583465576 6.495501518249512 1.4024652154417372 1.8130581378936768 62.092784942616305 349.07261152797196 37.74198707459574 209.16533457246305 26.02426004356846 999.0313634858431 CONFLICT 0.47058823529411764 0.5294117647058824 0.0 GO:2001234 7 negative regulation of apoptotic signaling pathway 88 93 4 4 2 2 2 2 50 91 2404 0.70502 0.57322 0.71489 2.15 360918;83619 pf4;nfe2l2 PF4_32963;NFE2L2_9301 93.13665 93.13665 6.6423 122.3214828386453 45.59365316258353 102.18547874957486 57.10065 57.10065 3.4063 75.93527799280778 27.58669547884187 63.43515918551021 220.07265 220.07265 13.4683 292.1826738152778 106.50927899777284 244.08489590932498 179.631;6.6423 110.795;3.4063 426.677;13.4683 2 0 2 360918;83619 PF4_32963;NFE2L2_9301 93.13665 93.13665 122.3214828386453 57.10065 57.10065 75.93527799280778 220.07265 220.07265 292.1826738152778 179.631;6.6423 110.795;3.4063 426.677;13.4683 0 0 Exp 4,1(0.5);Poly 2,1(0.5) 1.6936601122936863 3.402160406112671 1.5423688888549805 1.8597915172576904 0.22445169304561383 1.7010802030563354 -76.39227599999998 262.665576 -48.140275999999986 162.34157599999998 -184.871876 625.0171760000001 UP 1.0 0.0 0.0 GO:0021773 8 striatal medium spiny neuron differentiation 1 1 1 1 1 1 1 1 51 0 2495 1.0 0.020416 0.020416 100.0 29200 inhba INHBA_33300 130.168 130.168 130.168 130.168 89.164 89.164 89.164 89.164 231.33 231.33 231.33 231.33 0.0 130.168 0.0 130.168 130.168 89.164 231.33 0 1 0 1 29200 INHBA_33300 130.168 130.168 89.164 89.164 231.33 231.33 130.168 89.164 231.33 0 Poly 2,1(1) 1.6357452869415283 1.6357452869415283 1.6357452869415283 1.6357452869415283 0.0 1.6357452869415283 130.168 130.168 89.164 89.164 231.33 231.33 DOWN 0.0 1.0 0.0 GO:0042701 8 progesterone secretion 1 1 1 1 1 1 1 1 51 0 2495 1.0 0.020416 0.020416 100.0 29200 inhba INHBA_33300 130.168 130.168 130.168 130.168 89.164 89.164 89.164 89.164 231.33 231.33 231.33 231.33 0.0 130.168 0.0 130.168 130.168 89.164 231.33 0 1 0 1 29200 INHBA_33300 130.168 130.168 89.164 89.164 231.33 231.33 130.168 89.164 231.33 0 Poly 2,1(1) 1.6357452869415283 1.6357452869415283 1.6357452869415283 1.6357452869415283 0.0 1.6357452869415283 130.168 130.168 89.164 89.164 231.33 231.33 DOWN 0.0 1.0 0.0 GO:0051173 6 positive regulation of nitrogen compound metabolic process 649 698 31 28 14 21 12 12 40 686 1809 0.297 0.80456 0.53346 1.72 246273;363140;360918;316351;83619;29200;24484;494344;25587;24330;25695;58919 trib3;rassf1;pf4;npas2;nfe2l2;inhba;igfbp3;ier2;id2;egr1;cebpd;ccnd1 TRIB3_10079;RASSF1_32475;PF4_32963;NPAS2_9350;NFE2L2_9301;INHBA_33300;IGFBP3_8881;IER2_32643;ID2_8861;EGR1_8533;CEBPD_8283;CCND1_8224 195.205995 87.53565 2.99674 259.93464736420367 248.96098634137377 298.57241301932936 119.46455533333335 37.8002 0.998544 163.55648923252068 147.62336646256458 183.39410781292943 347.37845 177.0475 10.914 399.8672521794417 411.9959909750431 423.30307926619884 16.8949;756.581;179.631;134.458;6.6423;130.168;44.9033;543.54;2.99674;8.26335;5.66035;512.733 6.46469;437.5;110.795;56.7249;3.4063;89.164;18.8755;375.947;0.998544;1.51678;2.15795;330.024 58.9909;940.187;426.677;320.448;13.4683;231.33;122.765;978.946;10.914;45.9052;16.35;1002.56 5 7 5 246273;363140;360918;83619;25587 TRIB3_10079;RASSF1_32475;PF4_32963;NFE2L2_9301;ID2_8861 192.54918800000002 16.8949 323.89994403003175 111.8329068 6.46469 187.8850572789908 290.04744 58.9909 402.84851583099197 16.8949;756.581;179.631;6.6423;2.99674 6.46469;437.5;110.795;3.4063;0.998544 58.9909;940.187;426.677;13.4683;10.914 7 316351;29200;24484;494344;24330;25695;58919 NPAS2_9350;INHBA_33300;IGFBP3_8881;IER2_32643;EGR1_8533;CEBPD_8283;CCND1_8224 197.10371428571426 130.168 232.20717489871822 124.91573285714286 56.7249 159.455103516304 388.32917142857144 231.33 424.56082241049086 134.458;130.168;44.9033;543.54;8.26335;5.66035;512.733 56.7249;89.164;18.8755;375.947;1.51678;2.15795;330.024 320.448;231.33;122.765;978.946;45.9052;16.35;1002.56 0 Exp 2,1(0.09);Exp 4,4(0.34);Hill,3(0.25);Linear,1(0.09);Poly 2,3(0.25) 1.9458156336925032 25.01716983318329 1.5423688888549805 5.289852619171143 1.0401529550361588 1.7573065757751465 48.13412314511521 342.2778668548848 26.923759908949506 212.00535075771717 121.13225362780167 573.6246463721983 CONFLICT 0.4166666666666667 0.5833333333333334 0.0 GO:0006790 4 sulfur compound metabolic process 86 101 14 12 5 12 5 5 47 96 2399 0.98447 0.052781 0.052781 4.95 24424;300850;116686;24763;296925 gstm2;gsta4;gsr;acsm3;aass GSTM2_8759;GSTA4_8757;GSR_8755;ACSM3_7976;AASS_7936 134.39407599999998 74.6342 3.28268 186.34869065169437 138.91188661303744 185.7546818767989 94.33667940000001 57.2867 0.808077 136.5980732696223 96.28999393624596 137.37321217616392 233.68508000000003 128.079 13.1174 293.6705403822998 249.12191998150718 286.8990143339434 3.28268;105.355;74.6342;460.125;28.5735 0.808077;75.6422;57.2867;331.8;6.14642 13.1174;172.041;106.529;748.659;128.079 3 2 3 24424;300850;116686 GSTM2_8759;GSTA4_8757;GSR_8755 61.09062666666667 74.6342 52.36660110721464 44.57899233333333 57.2867 39.00193414307651 97.22913333333334 106.529 79.86891322193716 3.28268;105.355;74.6342 0.808077;75.6422;57.2867 13.1174;172.041;106.529 2 24763;296925 ACSM3_7976;AASS_7936 244.34925 244.34925 305.15299208122633 168.97321 168.97321 230.27185473567587 438.369 438.369 438.8163262687475 460.125;28.5735 331.8;6.14642 748.659;128.079 0 Hill,2(0.4);Linear,1(0.2);Poly 2,2(0.4) 1.785746832535021 8.975848197937012 1.6175053119659424 2.0709805488586426 0.20827639140876522 1.7059084177017212 -28.947753207585123 297.7359052075851 -25.396810951137965 214.07016975113794 -23.728498183296438 491.0986581832964 UP 0.6 0.4 0.0 GO:0032731 8 positive regulation of interleukin-1 beta production 22 23 3 3 3 3 3 3 49 20 2475 0.99897 0.010657 0.010657 13.04 24614;24539;24330 orm1;lpl;egr1 ORM1_9400;LPL_32544;EGR1_8533 278.2268833333333 56.9823 8.26335 426.0955813332096 321.7648147248634 435.6988516735389 153.93632666666667 16.0812 1.51678 251.49069578527977 178.37722565331495 258.4712259020871 830.6833999999999 262.985 45.9052 1176.2974220207575 958.0653121541969 1194.9163762797584 0.5 32.622825 1.5 413.20865 56.9823;769.435;8.26335 16.0812;444.211;1.51678 262.985;2183.16;45.9052 1 2 1 24614 ORM1_9400 56.9823 56.9823 16.0812 16.0812 262.985 262.985 56.9823 16.0812 262.985 2 24539;24330 LPL_32544;EGR1_8533 388.84917499999995 388.84917499999995 538.2296353619533 222.86389 222.86389 313.0320849540894 1114.5326 1114.5326 1511.2673622034981 769.435;8.26335 444.211;1.51678 2183.16;45.9052 0 Exp 2,1(0.34);Exp 4,1(0.34);Hill,1(0.34) 2.419788636870403 8.564767241477966 1.5846891403198242 5.289852619171143 2.1093715435005205 1.6902254819869995 -203.9456578898144 760.3994245564811 -130.65218631755573 438.5248396508891 -500.42244117146424 2161.789241171464 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:1901701 5 cellular response to oxygen-containing compound 359 378 31 27 16 19 12 12 40 366 2129 0.96406 0.073557 0.11154 3.17 286954;246273;360918;24614;24314;83619;59107;24539;29200;24484;297417;24330 ugt2b1;trib3;pf4;orm1;nqo1;nfe2l2;ltbp1;lpl;inhba;igfbp3;gfpt1;egr1 UGT2B10_33303,UGT2B1_33224;TRIB3_10079;PF4_32963;ORM1_9400;NQO1_33055;NFE2L2_9301;LTBP1_33264;LPL_32544;INHBA_33300;IGFBP3_8881;GFPT1_8705;EGR1_8533 270.2337875 50.942800000000005 6.6423 396.88742974219355 291.16081713969965 404.61291711235606 148.35706416666667 17.6453 1.51678 217.33462719890665 155.70970336180383 219.9427519113219 1062.7252125 177.0475 13.4683 1788.5956475919697 1136.869968673166 1803.147629186399 25.4966;16.8949;179.631;56.9823;24.1117;6.6423;998.777;769.435;130.168;44.9033;981.5;8.26335 11.3392;6.46469;110.795;16.0812;16.4151;3.4063;507.146;444.211;89.164;18.8755;554.87;1.51678 63.97775;58.9909;426.677;262.985;37.0434;13.4683;5065.92;2183.16;231.33;122.765;4240.48;45.9052 8 5 7 286954;246273;360918;24614;24314;83619;297417 UGT2B10_33303,UGT2B1_33224;TRIB3_10079;PF4_32963;ORM1_9400;NQO1_33055;NFE2L2_9301;GFPT1_8705 184.46554285714288 25.4966 356.42315245762234 102.76735571428571 16.0812 202.8703921949637 729.0889071428571 63.97775 1555.6894103413315 25.4966;16.8949;179.631;56.9823;24.1117;6.6423;981.5 11.3392;6.46469;110.795;16.0812;16.4151;3.4063;554.87 63.97775;58.9909;426.677;262.985;37.0434;13.4683;4240.48 5 59107;24539;29200;24484;24330 LTBP1_33264;LPL_32544;INHBA_33300;IGFBP3_8881;EGR1_8533 390.30933 130.168 460.13779106286955 212.182656 89.164 243.78365630141553 1529.8160400000002 231.33 2167.8756625038272 998.777;769.435;130.168;44.9033;8.26335 507.146;444.211;89.164;18.8755;1.51678 5065.92;2183.16;231.33;122.765;45.9052 0 Exp 2,2(0.16);Exp 4,7(0.54);Hill,1(0.08);Linear,1(0.08);Poly 2,2(0.16) 2.0079395757646035 28.86780822277069 1.5232417583465576 5.289852619171143 1.2662483275229206 1.6902254819869995 45.67358438835859 494.79399061164145 25.38842275950128 271.32570557383207 50.73195746355532 2074.7184675364447 CONFLICT 0.5833333333333334 0.4166666666666667 0.0 GO:0030182 5 neuron differentiation 63 68 4 4 3 3 3 3 49 65 2430 0.95185 0.16005 0.16005 4.41 29200;494344;25587 inhba;ier2;id2 INHBA_33300;IER2_32643;ID2_8861 225.56824666666662 130.168 2.99674 282.6175141085608 275.6402123623154 287.33711723112356 155.36984800000002 89.164 0.998544 196.04590507390176 190.10189855636276 199.32395452051014 407.06333333333333 231.33 10.914 507.3786964283516 496.66831169439894 516.4973802331938 130.168;543.54;2.99674 89.164;375.947;0.998544 231.33;978.946;10.914 1 2 1 25587 ID2_8861 2.99674 2.99674 0.998544 0.998544 10.914 10.914 2.99674 0.998544 10.914 2 29200;494344 INHBA_33300;IER2_32643 336.854 336.854 292.29814435264547 232.5555 232.5555 202.78620402902166 605.138 605.138 528.6443433235618 130.168;543.54 89.164;375.947 231.33;978.946 0 Hill,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 1.7193164140394372 5.184507131576538 1.5710276365280151 1.9777342081069946 0.21853871962060972 1.6357452869415283 -94.24357711596298 545.3800704492962 -66.47697789316442 377.2166738931644 -167.0897115160874 981.2163781827542 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0071156 7 regulation of cell cycle arrest 20 21 3 3 3 3 3 3 49 18 2477 0.99928 0.0082364 0.0082364 14.29 363140;25587;58919 rassf1;id2;ccnd1 RASSF1_32475;ID2_8861;CCND1_8224 424.10357999999997 512.733 2.99674 384.5304796724041 586.5722985704896 285.98785772668873 256.1741813333333 330.024 0.998544 227.4285097791274 351.16563321721986 162.1027935534306 651.2203333333333 940.187 10.914 555.3978287339024 861.071912750575 366.39513905311225 0.5 257.86487 1.5 634.6569999999999 756.581;2.99674;512.733 437.5;0.998544;330.024 940.187;10.914;1002.56 2 1 2 363140;25587 RASSF1_32475;ID2_8861 379.78887000000003 379.78887000000003 532.8645404414464 219.249272 219.249272 308.6531395354014 475.5505 475.5505 657.0952398735666 756.581;2.99674 437.5;0.998544 940.187;10.914 1 58919 CCND1_8224 512.733 512.733 330.024 330.024 1002.56 1002.56 512.733 330.024 1002.56 0 Exp 2,1(0.34);Hill,1(0.34);Poly 2,1(0.34) 1.8900245791269423 5.727892518043518 1.555469274520874 2.1946890354156494 0.32505870596642306 1.9777342081069946 -11.033620862937767 859.2407808629378 -1.185404897721014 513.5337675643876 22.728524916702895 1279.7121417499638 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0045860 8 positive regulation of protein kinase activity 136 148 2 2 2 2 2 2 50 146 2349 0.40928 0.81587 0.76687 1.35 24330;58919 egr1;ccnd1 EGR1_8533;CCND1_8224 260.49817499999995 260.49817499999995 8.26335 356.71391041780424 293.9452396212578 353.56385791254746 165.77039 165.77039 1.51678 232.28968293074104 187.55089199033733 230.23839007029653 524.2325999999999 524.2325999999999 45.9052 676.4570963346604 587.6601915624192 670.4834706677724 8.26335;512.733 1.51678;330.024 45.9052;1002.56 0 2 0 2 24330;58919 EGR1_8533;CCND1_8224 260.49817499999995 260.49817499999995 356.71391041780424 165.77039 165.77039 232.28968293074104 524.2325999999999 524.2325999999999 676.4570963346604 8.26335;512.733 1.51678;330.024 45.9052;1002.56 0 Exp 2,1(0.5);Hill,1(0.5) 2.8684844806734584 6.845321893692017 1.555469274520874 5.289852619171143 2.6406077865523048 3.4226609468460083 -233.88208199999997 754.8784319999999 -156.1666856 487.70746560000003 -413.28910399999995 1461.7543039999998 DOWN 0.0 1.0 0.0 GO:0045600 7 positive regulation of fat cell differentiation 16 17 4 4 3 2 2 2 50 15 2480 0.99554 0.045728 0.045728 11.76 24539;25587 lpl;id2 LPL_32544;ID2_8861 386.21587 386.21587 2.99674 541.9536910068182 630.1397163432631 417.9905711450081 222.604772 222.604772 0.998544 313.39853314394435 363.6599523804317 241.71369996850348 1097.037 1097.037 10.914 1536.0098770053528 1788.3680923749655 1184.672521707696 0.0 2.99674 0.5 386.21587 769.435;2.99674 444.211;0.998544 2183.16;10.914 1 1 1 25587 ID2_8861 2.99674 2.99674 0.998544 0.998544 10.914 10.914 2.99674 0.998544 10.914 1 24539 LPL_32544 769.435 769.435 444.211 444.211 2183.16 2183.16 769.435 444.211 2183.16 0 Exp 2,1(0.5);Hill,1(0.5) 1.828337155761984 3.667959690093994 1.6902254819869995 1.9777342081069946 0.20329936988975442 1.833979845046997 -364.8936247999999 1137.3253648 -211.74343488000002 656.95297888 -1031.7640799999992 3225.8380799999995 CONFLICT 0.5 0.5 0.0 GO:0009636 4 response to toxic substance 240 257 19 19 15 15 12 12 40 245 2250 0.99858 0.0044404 0.0044404 4.67 286954;24314;83619;300850;116686;25315;24330;24296;58919;54232;25612;24188 ugt2b1;nqo1;nfe2l2;gsta4;gsr;ephx1;egr1;cyp1a1;ccnd1;car3;asns;aldh1a1 UGT2B10_33303,UGT2B1_33224;NQO1_33055;NFE2L2_9301;GSTA4_8757;GSR_8755;EPHX1_8567;EGR1_8533;CYP1A1_8415;CCND1_8224;CAR3_8196;ASNS_8091;ALDH1A1_8022 98.47728749999999 64.9221 6.6423 138.24870729577466 120.25806557874515 158.33638358468494 60.72369 39.12785 1.51678 89.20590183309072 78.0019980448965 102.01813149902418 195.43859583333332 106.6215 13.4683 280.559431718477 228.5953742634026 316.4580165774197 25.4966;24.1117;6.6423;105.355;74.6342;24.8784;8.26335;100.909;512.733;55.21;154.987;88.5069 11.3392;16.4151;3.4063;75.6422;57.2867;15.4867;1.51678;73.3629;330.024;24.6611;53.5946;65.9487 63.97775;37.0434;13.4683;172.041;106.529;41.3795;45.9052;159.385;1002.56;106.714;462.615;133.645 10 3 9 286954;24314;83619;300850;116686;25315;24296;25612;24188 UGT2B10_33303,UGT2B1_33224;NQO1_33055;NFE2L2_9301;GSTA4_8757;GSR_8755;EPHX1_8567;CYP1A1_8415;ASNS_8091;ALDH1A1_8022 67.28012222222223 74.6342 49.8271758687159 41.38693333333333 53.5946 29.242103976073615 132.23155 106.529 136.11397556925408 25.4966;24.1117;6.6423;105.355;74.6342;24.8784;100.909;154.987;88.5069 11.3392;16.4151;3.4063;75.6422;57.2867;15.4867;73.3629;53.5946;65.9487 63.97775;37.0434;13.4683;172.041;106.529;41.3795;159.385;462.615;133.645 3 24330;58919;54232 EGR1_8533;CCND1_8224;CAR3_8196 192.0687833333333 55.21 278.6936523754906 118.73396000000001 24.6611 183.34809963418436 385.0597333333333 106.714 535.6345414920636 8.26335;512.733;55.21 1.51678;330.024;24.6611 45.9052;1002.56;106.714 0 Exp 2,1(0.08);Exp 4,6(0.47);Exp 5,1(0.08);Hill,1(0.08);Poly 2,4(0.31) 2.365605414545198 33.32599711418152 1.5423688888549805 5.289852619171143 1.1904768148652518 2.0709805488586426 20.25571769511336 176.69885730488662 10.250699592094499 111.19668040790549 36.69715367550927 354.1800379911574 UP 0.75 0.25 0.0 GO:0051049 5 regulation of transport 454 483 21 20 13 14 9 9 43 474 2021 0.46285 0.67648 0.85956 1.86 246273;170698;24614;83619;24539;29200;24484;24424;114628 trib3;slco1a2;orm1;nfe2l2;lpl;inhba;igfbp3;gstm2;abcg5 TRIB3_10079;SLCO1A2_9886;ORM1_9400;NFE2L2_9301;LPL_32544;INHBA_33300;IGFBP3_8881;GSTM2_8759;ABCG5_7947 203.36338666666668 56.9823 3.28268 266.256725696187 263.56597898589047 295.54961357022165 128.0009741111111 18.8755 0.808077 166.94985266730322 162.5755172883268 182.72345544988733 465.2139555555555 231.33 13.1174 692.4724404906524 637.3661944833572 803.4976136381554 16.8949;440.994;56.9823;6.6423;769.435;130.168;44.9033;3.28268;360.968 6.46469;299.351;16.0812;3.4063;444.211;89.164;18.8755;0.808077;273.647 58.9909;772.521;262.985;13.4683;2183.16;231.33;122.765;13.1174;528.588 4 5 4 246273;24614;83619;24424 TRIB3_10079;ORM1_9400;NFE2L2_9301;GSTM2_8759 20.950544999999998 11.7686 24.709073592402586 6.69006675 4.9354949999999995 6.673956994322703 87.1404 36.229600000000005 119.19270188343471 16.8949;56.9823;6.6423;3.28268 6.46469;16.0812;3.4063;0.808077 58.9909;262.985;13.4683;13.1174 5 170698;24539;29200;24484;114628 SLCO1A2_9886;LPL_32544;INHBA_33300;IGFBP3_8881;ABCG5_7947 349.29366 360.968 285.3653510321952 225.04970000000003 273.647 170.94354358734927 767.6727999999999 528.588 831.3180392621706 440.994;769.435;130.168;44.9033;360.968 299.351;444.211;89.164;18.8755;273.647 772.521;2183.16;231.33;122.765;528.588 0 Exp 2,2(0.23);Exp 4,4(0.45);Hill,1(0.12);Linear,1(0.12);Poly 2,1(0.12) 1.7523634490263367 15.907575011253357 1.5423688888549805 2.2692105770111084 0.257962873876782 1.672735333442688 29.408992545157815 377.3177807881756 18.92707036847301 237.0748778537492 12.798627768329311 917.6292833427818 CONFLICT 0.4444444444444444 0.5555555555555556 0.0 GO:0006875 8 cellular metal ion homeostasis 132 139 5 5 4 3 2 2 50 137 2358 0.45297 0.78688 1.0 1.44 24424;117517 gstm2;c7 GSTM2_8759;C7_8179 8.56279 8.56279 3.28268 7.467203172821805 10.550062671009773 6.9181368797036225 3.0684685 3.0684685 0.808077 3.1966763155728644 3.919211051525022 2.961623488661902 27.50685 27.50685 13.1174 20.349755345089523 32.92260094758661 18.853430084534473 3.28268;13.8429 0.808077;5.32886 13.1174;41.8963 1 1 1 24424 GSTM2_8759 3.28268 3.28268 0.808077 0.808077 13.1174 13.1174 3.28268 0.808077 13.1174 1 117517 C7_8179 13.8429 13.8429 5.32886 5.32886 41.8963 41.8963 13.8429 5.32886 41.8963 0 Hill,2(1) 2.0491661869200066 4.167401671409607 1.7059084177017212 2.4614932537078857 0.5342791613016844 2.0837008357048035 -1.7862256000000016 18.9118056 -1.3618988399999985 7.498835839999998 -0.6964719999999929 55.71017199999999 CONFLICT 0.5 0.5 0.0 GO:0009067 8 aspartate family amino acid biosynthetic process 9 9 3 3 2 3 2 2 50 7 2488 0.99938 0.01343 0.01343 22.22 25612;296925 asns;aass ASNS_8091;AASS_7936 91.78025 91.78025 28.5735 89.38784308352564 64.07552046023011 80.3435275139286 29.87051 29.87051 6.14642 33.55092983295992 19.4717868094047 30.156226631774594 295.347 295.347 128.079 236.55267415102293 222.0302308154077 212.61813271841714 0.0 28.5735 0.0 28.5735 154.987;28.5735 53.5946;6.14642 462.615;128.079 1 1 1 25612 ASNS_8091 154.987 154.987 53.5946 53.5946 462.615 462.615 154.987 53.5946 462.615 1 296925 AASS_7936 28.5735 28.5735 6.14642 6.14642 128.079 128.079 28.5735 6.14642 128.079 0 Exp 4,1(0.5);Hill,1(0.5) 2.0641599479921786 4.251658201217651 1.6175053119659424 2.634152889251709 0.7188783959756402 2.1258291006088257 -32.10497999999998 215.66547999999997 -16.628706399999995 76.36972639999999 -32.498279999999966 623.19228 CONFLICT 0.5 0.5 0.0 GO:0032355 5 response to estradiol 114 121 8 8 6 7 5 5 47 116 2379 0.96548 0.097847 0.097847 4.13 24314;24484;58919;24188;140668 nqo1;igfbp3;ccnd1;aldh1a1;abcc3 NQO1_33055;IGFBP3_8881;CCND1_8224;ALDH1A1_8022;ABCC3_7941 151.34936 86.4919 24.1117 203.8835365888771 151.71744614042865 199.62335331989203 94.34262 40.4498 16.4151 133.25196827220603 92.99964682039911 131.43436176078055 280.80668 122.765 37.0434 405.2275166713288 283.15730865927566 395.77969261140316 24.1117;44.9033;512.733;88.5069;86.4919 16.4151;18.8755;330.024;65.9487;40.4498 37.0434;122.765;1002.56;133.645;108.02 3 2 3 24314;24188;140668 NQO1_33055;ALDH1A1_8022;ABCC3_7941 66.37016666666666 86.4919 36.61077109285371 40.93786666666667 40.4498 24.770406517522744 92.9028 108.02 50.04362679223 24.1117;88.5069;86.4919 16.4151;65.9487;40.4498 37.0434;133.645;108.02 2 24484;58919 IGFBP3_8881;CCND1_8224 278.81814999999995 278.81814999999995 330.8055533104682 174.44975 174.44975 220.01521430602247 562.6625 562.6625 622.1090105540184 44.9033;512.733 18.8755;330.024 122.765;1002.56 0 Exp 2,1(0.2);Exp 4,2(0.4);Exp 5,1(0.2);Poly 2,1(0.2) 2.587027798309926 14.152251243591309 1.555469274520874 4.773829460144043 1.3299758748938493 2.79919695854187 -27.362439343871586 330.06115934387157 -22.457880003380737 211.14312000338072 -74.39089926316399 636.004259263164 UP 0.6 0.4 0.0 GO:0051094 5 positive regulation of developmental process 376 396 20 20 11 15 9 9 43 387 2108 0.71795 0.41989 0.69932 2.27 360918;83619;24539;29200;24484;25587;24330;25695;58919 pf4;nfe2l2;lpl;inhba;igfbp3;id2;egr1;cebpd;ccnd1 PF4_32963;NFE2L2_9301;LPL_32544;INHBA_33300;IGFBP3_8881;ID2_8861;EGR1_8533;CEBPD_8283;CCND1_8224 184.49256 44.9033 2.99674 273.85409895302143 252.7815176113225 327.0872490068371 111.238786 18.8755 0.998544 164.11666515814545 149.94583540712551 194.8136093242724 450.3477222222222 122.765 10.914 724.5092906448159 641.6077920889244 886.6579039484311 179.631;6.6423;769.435;130.168;44.9033;2.99674;8.26335;5.66035;512.733 110.795;3.4063;444.211;89.164;18.8755;0.998544;1.51678;2.15795;330.024 426.677;13.4683;2183.16;231.33;122.765;10.914;45.9052;16.35;1002.56 3 6 3 360918;83619;25587 PF4_32963;NFE2L2_9301;ID2_8861 63.09001333333333 6.6423 100.94391366921799 38.399948 3.4063 62.70751141451009 150.3531 13.4683 239.3069250889535 179.631;6.6423;2.99674 110.795;3.4063;0.998544 426.677;13.4683;10.914 6 24539;29200;24484;24330;25695;58919 LPL_32544;INHBA_33300;IGFBP3_8881;EGR1_8533;CEBPD_8283;CCND1_8224 245.19383333333334 87.53565 320.39525282877344 147.65820499999998 54.01975 191.6950916638654 600.3450333333333 177.0475 857.8797828278776 769.435;130.168;44.9033;8.26335;5.66035;512.733 444.211;89.164;18.8755;1.51678;2.15795;330.024 2183.16;231.33;122.765;45.9052;16.35;1002.56 0 Exp 2,2(0.23);Exp 4,3(0.34);Hill,2(0.23);Poly 2,2(0.23) 1.9091365576737613 18.783605575561523 1.5423688888549805 5.289852619171143 1.2097678630075421 1.6548216342926025 5.574548684025956 363.410571315974 4.0158980966783275 218.4616739033217 -22.998347665724225 923.6937921101685 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0044849 4 estrous cycle 13 15 2 2 2 2 2 2 50 13 2482 0.99693 0.03623 0.03623 13.33 24330;24188 egr1;aldh1a1 EGR1_8533;ALDH1A1_8022 48.385125 48.385125 8.26335 56.74075835148179 52.969561805127306 56.369136383847845 33.73274 33.73274 1.51678 45.560247556869136 37.413834187296274 45.26185202366013 89.77510000000001 89.77510000000001 45.9052 62.04140755995143 94.78780903885121 61.63506914252338 0.0 8.26335 0.5 48.385125 8.26335;88.5069 1.51678;65.9487 45.9052;133.645 1 1 1 24188 ALDH1A1_8022 88.5069 88.5069 65.9487 65.9487 133.645 133.645 88.5069 65.9487 133.645 1 24330 EGR1_8533 8.26335 8.26335 1.51678 1.51678 45.9052 45.9052 8.26335 1.51678 45.9052 0 Hill,1(0.5);Poly 2,1(0.5) 3.848030582352303 8.089049577713013 2.79919695854187 5.289852619171143 1.7611595072316188 4.044524788856506 -30.253553999999994 127.023804 -29.410541599999995 96.8760216 3.7900960000000197 175.760104 CONFLICT 0.5 0.5 0.0 GO:0055086 5 nucleobase-containing small molecule metabolic process 108 122 11 8 3 8 3 3 49 119 2376 0.76356 0.45811 0.73666 2.46 297417;24763;296925 gfpt1;acsm3;aass GFPT1_8705;ACSM3_7976;AASS_7936 490.0661666666667 460.125 28.5735 477.16829703636364 256.8592532964864 359.3789725207751 297.60547333333335 331.8 6.14642 275.9553243778277 164.80030848480064 233.26761760267235 1705.7393333333332 748.659 128.079 2216.9714859556334 675.4646701144887 1334.627140614864 981.5;460.125;28.5735 554.87;331.8;6.14642 4240.48;748.659;128.079 1 2 1 297417 GFPT1_8705 981.5 981.5 554.87 554.87 4240.48 4240.48 981.5 554.87 4240.48 2 24763;296925 ACSM3_7976;AASS_7936 244.34925 244.34925 305.15299208122633 168.97321 168.97321 230.27185473567587 438.369 438.369 438.8163262687475 460.125;28.5735 331.8;6.14642 748.659;128.079 0 Hill,1(0.34);Linear,2(0.67) 1.5864701145474716 4.761366844177246 1.5232417583465576 1.620619773864746 0.055344068215925794 1.6175053119659424 -49.90059302902512 1030.0329263623585 -14.667373061811418 609.8783197284781 -803.0000717029984 4214.478738369664 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0010564 6 regulation of cell cycle process 146 156 6 6 4 5 4 4 48 152 2343 0.78964 0.39566 0.55697 2.56 363140;25587;24296;58919 rassf1;id2;cyp1a1;ccnd1 RASSF1_32475;ID2_8861;CYP1A1_8415;CCND1_8224 343.304935 306.82099999999997 2.99674 353.1139721582871 415.8527224400639 344.7244141194559 210.471361 201.69344999999998 0.998544 206.97216202327039 253.51286636760784 196.47690330789092 528.2615 549.7860000000001 10.914 515.8681978506396 614.4160656366541 476.4776151958392 756.581;2.99674;100.909;512.733 437.5;0.998544;73.3629;330.024 940.187;10.914;159.385;1002.56 3 1 3 363140;25587;24296 RASSF1_32475;ID2_8861;CYP1A1_8415 286.82891333333333 100.909 409.752327461776 170.62048133333334 73.3629 233.93943258381526 370.162 159.385 499.20665553355764 756.581;2.99674;100.909 437.5;0.998544;73.3629 940.187;10.914;159.385 1 58919 CCND1_8224 512.733 512.733 330.024 330.024 1002.56 1002.56 512.733 330.024 1002.56 0 Exp 2,1(0.25);Hill,1(0.25);Poly 2,2(0.5) 1.8940543191756174 7.634087681770325 1.555469274520874 2.1946890354156494 0.2654138548536879 1.9419646859169006 -2.746757715121362 689.3566277151214 7.638642217195041 413.30407978280493 22.71066610637314 1033.8123338936268 UP 0.75 0.25 0.0 GO:0045454 4 cell redox homeostasis 21 21 3 3 3 3 3 3 49 18 2477 0.99928 0.0082364 0.0082364 14.29 24314;83619;116686 nqo1;nfe2l2;gsr NQO1_33055;NFE2L2_9301;GSR_8755 35.129400000000004 24.1117 6.6423 35.30958653637848 43.93045948481239 37.070629405428484 25.702700000000004 16.4151 3.4063 28.115280744819174 32.73905622394282 29.55313734315857 52.3469 37.0434 13.4683 48.38100149139123 64.41780666319238 50.80863051554757 0.5 15.376999999999999 1.5 49.37295 24.1117;6.6423;74.6342 16.4151;3.4063;57.2867 37.0434;13.4683;106.529 3 0 3 24314;83619;116686 NQO1_33055;NFE2L2_9301;GSR_8755 35.129400000000004 24.1117 35.30958653637848 25.702700000000004 16.4151 28.115280744819174 52.3469 37.0434 48.38100149139123 24.1117;6.6423;74.6342 16.4151;3.4063;57.2867 37.0434;13.4683;106.529 0 0 Exp 4,2(0.67);Poly 2,1(0.34) 2.4349983574089085 8.277032494544983 1.5423688888549805 4.773829460144043 1.7573840992985403 1.9608341455459595 -4.8271586118349035 75.08595861183491 -6.112735216471979 57.518135216471975 -2.401357100048081 107.09515710004808 UP 1.0 0.0 0.0 GO:0044255 4 cellular lipid metabolic process 218 243 26 24 12 21 11 11 41 232 2263 0.99722 0.0083157 0.013461 4.53 305291;24539;24424;25598;25315;499353;29277;24296;290277;24188;24763 srd5a3;lpl;gstm2;fabp2;ephx1;cyp2c24;cyp2c11;cyp1a1;cryl1;aldh1a1;acsm3 SRD5A3_9939;LPL_32544;GSTM2_8759;FABP2_32859;EPHX1_8567;CYP2C24_32875;CYP2C11_32593;CYP1A1_8415;CRYL1_8388;ALDH1A1_8022;ACSM3_7976 245.71728000000002 129.934 3.28268 277.4355224281094 342.3971847547593 310.0868214811399 151.34667063636363 73.3629 0.808077 174.04176537669247 213.95372587241698 186.9731554069985 584.3134454545454 319.535 13.1174 723.1066474227316 829.8038495507386 848.2655622452493 169.209;769.435;3.28268;146.645;24.8784;733.935;129.934;100.909;76.0301;88.5069;460.125 105.547;444.211;0.808077;95.8536;15.4867;463.206;45.3106;73.3629;23.2788;65.9487;331.8 459.211;2183.16;13.1174;319.535;41.3795;1763.75;355.143;159.385;250.463;133.645;748.659 7 4 7 305291;24424;25598;25315;24296;290277;24188 SRD5A3_9939;GSTM2_8759;FABP2_32859;EPHX1_8567;CYP1A1_8415;CRYL1_8388;ALDH1A1_8022 87.06586857142858 88.5069 59.860348485010626 54.326539571428576 65.9487 41.19508678670706 196.67655714285715 159.385 158.15935511430504 169.209;3.28268;146.645;24.8784;100.909;76.0301;88.5069 105.547;0.808077;95.8536;15.4867;73.3629;23.2788;65.9487 459.211;13.1174;319.535;41.3795;159.385;250.463;133.645 4 24539;499353;29277;24763 LPL_32544;CYP2C24_32875;CYP2C11_32593;ACSM3_7976 523.35725 597.03 296.4666473207116 321.1319 388.0055 192.80794644664766 1262.6779999999999 1256.2045 853.6579272155794 769.435;733.935;129.934;460.125 444.211;463.206;45.3106;331.8 2183.16;1763.75;355.143;748.659 0 Exp 2,1(0.1);Exp 4,2(0.19);Hill,2(0.19);Linear,2(0.19);Poly 2,4(0.37) 1.8977659285749124 21.28181743621826 1.5321133136749268 2.79919695854187 0.42258219301570216 1.7059084177017212 81.76336349417022 409.67119650582976 48.494559921191765 254.1987813515355 156.984724680954 1011.6421662281371 UP 0.6363636363636364 0.36363636363636365 0.0 GO:0003008 3 system process 296 309 9 9 6 6 4 4 48 305 2190 0.22524 0.89249 0.39644 1.29 24424;25598;24330;114628 gstm2;fabp2;egr1;abcg5 GSTM2_8759;FABP2_32859;EGR1_8533;ABCG5_7947 129.7897575 77.454175 3.28268 167.82946442005715 190.25983354347707 175.9228599152506 92.95636425 48.68519 0.808077 128.46530560641864 138.7757834803286 136.74321955615582 226.78640000000001 182.7201 13.1174 243.624683094687 316.1297966819402 239.45717725686566 3.28268;146.645;8.26335;360.968 0.808077;95.8536;1.51678;273.647 13.1174;319.535;45.9052;528.588 2 2 2 24424;25598 GSTM2_8759;FABP2_32859 74.96384 74.96384 101.37246863863581 48.3308385 48.3308385 67.20733383472196 166.3262 166.3262 216.66996283490707 3.28268;146.645 0.808077;95.8536 13.1174;319.535 2 24330;114628 EGR1_8533;ABCG5_7947 184.615675 184.615675 249.39984977102785 137.58189 137.58189 192.42512392778704 287.2466 287.2466 341.30828104210997 8.26335;360.968 1.51678;273.647 45.9052;528.588 0 Hill,2(0.5);Linear,1(0.25);Poly 2,1(0.25) 2.52386908386357 11.23717725276947 1.7059084177017212 5.289852619171143 1.6654202698933402 2.1207081079483032 -34.68311763165599 294.262632631656 -32.93963524429027 218.85236374429024 -11.96578943279323 465.5385894327933 CONFLICT 0.5 0.5 0.0 GO:0006950 3 response to stress 773 821 46 43 26 33 21 21 31 800 1695 0.92023 0.13191 0.23027 2.56 24522;246273;363140;360918;24614;338475;24314;83619;307126;59107;24539;24484;25587;300850;116686;24330;24296;58919;54232;25612;24188 zfp354a;trib3;rassf1;pf4;orm1;nrep;nqo1;nfe2l2;mcm10;ltbp1;lpl;igfbp3;id2;gsta4;gsr;egr1;cyp1a1;ccnd1;car3;asns;aldh1a1 ZFP354A_10203;TRIB3_10079;RASSF1_32475;PF4_32963;ORM1_9400;NREP_9364;NQO1_33055;NFE2L2_9301;MCM10_32579;LTBP1_33264;LPL_32544;IGFBP3_8881;ID2_8861;GSTA4_8757;GSR_8755;EGR1_8533;CYP1A1_8415;CCND1_8224;CAR3_8196;ASNS_8091;ALDH1A1_8022 204.14537238095238 88.5069 2.99674 292.25937184803803 264.12163280269823 330.4687848372791 116.58519447619048 57.2867 0.998544 162.22361259037277 151.066616539489 183.24478359894286 579.9336666666667 159.385 6.6682 1147.2265212727216 742.6811531399628 1279.109569436082 3.26713;16.8949;756.581;179.631;56.9823;112.624;24.1117;6.6423;213.608;998.777;769.435;44.9033;2.99674;105.355;74.6342;8.26335;100.909;512.733;55.21;154.987;88.5069 1.71987;6.46469;437.5;110.795;16.0812;79.4619;16.4151;3.4063;123.177;507.146;444.211;18.8755;0.998544;75.6422;57.2867;1.51678;73.3629;330.024;24.6611;53.5946;65.9487 6.6682;58.9909;940.187;426.677;262.985;192.339;37.0434;13.4683;668.095;5065.92;2183.16;122.765;10.914;172.041;106.529;45.9052;159.385;1002.56;106.714;462.615;133.645 12 9 12 246273;363140;360918;24614;24314;83619;25587;300850;116686;24296;25612;24188 TRIB3_10079;RASSF1_32475;PF4_32963;ORM1_9400;NQO1_33055;NFE2L2_9301;ID2_8861;GSTA4_8757;GSR_8755;CYP1A1_8415;ASNS_8091;ALDH1A1_8022 130.68600333333333 81.57055 205.07427270569724 76.4579945 55.440650000000005 118.98111818592426 232.04004999999998 146.515 268.40121530330975 16.8949;756.581;179.631;56.9823;24.1117;6.6423;2.99674;105.355;74.6342;100.909;154.987;88.5069 6.46469;437.5;110.795;16.0812;16.4151;3.4063;0.998544;75.6422;57.2867;73.3629;53.5946;65.9487 58.9909;940.187;426.677;262.985;37.0434;13.4683;10.914;172.041;106.529;159.385;462.615;133.645 9 24522;338475;307126;59107;24539;24484;24330;58919;54232 ZFP354A_10203;NREP_9364;MCM10_32579;LTBP1_33264;LPL_32544;IGFBP3_8881;EGR1_8533;CCND1_8224;CAR3_8196 302.0911977777778 112.624 369.8994743258358 170.08812777777777 79.4619 201.71857169175962 1043.7918222222224 192.339 1663.62944219872 3.26713;112.624;213.608;998.777;769.435;44.9033;8.26335;512.733;55.21 1.71987;79.4619;123.177;507.146;444.211;18.8755;1.51678;330.024;24.6611 6.6682;192.339;668.095;5065.92;2183.16;122.765;45.9052;1002.56;106.714 0 Exp 2,3(0.15);Exp 4,7(0.34);Exp 5,1(0.05);Hill,2(0.1);Poly 2,8(0.39) 2.276137982369466 52.58714425563812 1.5423688888549805 6.495501518249512 1.343672918969506 1.9777342081069946 79.14397426925693 329.1467704926478 47.201009283763526 185.96937966861742 89.25677852064285 1070.6105548126905 CONFLICT 0.5714285714285714 0.42857142857142855 0.0 GO:0034371 9 chylomicron remodeling 2 2 1 1 1 1 1 1 51 1 2494 0.99959 0.040423 0.040423 50.0 24539 lpl LPL_32544 769.435 769.435 769.435 769.435 444.211 444.211 444.211 444.21099999999996 2183.16 2183.16 2183.16 2183.16 0.0 769.435 0.0 769.435 769.435 444.211 2183.16 0 1 0 1 24539 LPL_32544 769.435 769.435 444.211 444.211 2183.16 2183.16 769.435 444.211 2183.16 0 Exp 2,1(1) 1.6902254819869995 1.6902254819869995 1.6902254819869995 1.6902254819869995 0.0 1.6902254819869995 769.435 769.435 444.211 444.211 2183.16 2183.16 DOWN 0.0 1.0 0.0 GO:0009404 4 toxin metabolic process 12 17 4 4 3 4 3 3 49 14 2481 0.9997 0.0044607 0.0044607 17.65 83619;24296;26760 nfe2l2;cyp1a1;akr7a3 NFE2L2_9301;CYP1A1_8415;AKR7A3_8015 42.46713333333334 19.8501 6.6423 51.041163092383904 59.02596102564103 52.893930214667655 29.8554 12.797 3.4063 37.97003066643481 42.15470354830355 39.393970876030764 68.40256666666666 32.3544 13.4683 79.35693778582521 94.07504782698783 82.40996327191586 0.0 6.6423 0.5 13.2462 6.6423;100.909;19.8501 3.4063;73.3629;12.797 13.4683;159.385;32.3544 3 0 3 83619;24296;26760 NFE2L2_9301;CYP1A1_8415;AKR7A3_8015 42.46713333333334 19.8501 51.041163092383904 29.8554 12.797 37.97003066643481 68.40256666666666 32.3544 79.35693778582521 6.6423;100.909;19.8501 3.4063;73.3629;12.797 13.4683;159.385;32.3544 0 0 Exp 4,2(0.67);Poly 2,1(0.34) 2.2968613569881446 7.570001602172852 1.5423688888549805 4.1214375495910645 1.3959025481271783 1.9061951637268066 -15.291379998899977 100.22564666556664 -13.111734555752793 72.8225345557528 -21.398262143046054 158.20339547637937 UP 1.0 0.0 0.0 GO:0051172 6 negative regulation of nitrogen compound metabolic process 471 499 28 26 12 16 8 8 44 491 2004 0.28356 0.82798 0.5957 1.6 24522;246273;299270;24484;25587;24330;25695;58919 zfp354a;trib3;serpina6;igfbp3;id2;egr1;cebpd;ccnd1 ZFP354A_10203;TRIB3_10079;SERPINA6_32325;IGFBP3_8881;ID2_8861;EGR1_8533;CEBPD_8283;CCND1_8224 76.32077124999999 12.055375000000002 2.99674 176.8652067388814 100.384728069041 198.1947677149467 46.188804250000004 4.31132 0.998544 114.84007212579544 61.08915336447646 128.98921505359652 163.1236875 43.3707 6.6682 341.21815625862513 211.26289325628164 381.6884780115017 3.26713;16.8949;15.8474;44.9033;2.99674;8.26335;5.66035;512.733 1.71987;6.46469;7.7531;18.8755;0.998544;1.51678;2.15795;330.024 6.6682;58.9909;40.8362;122.765;10.914;45.9052;16.35;1002.56 2 6 2 246273;25587 TRIB3_10079;ID2_8861 9.94582 9.94582 9.827483182015628 3.731617 3.731617 3.865148903555722 34.95245 34.95245 33.995502008427536 16.8949;2.99674 6.46469;0.998544 58.9909;10.914 6 24522;299270;24484;24330;25695;58919 ZFP354A_10203;SERPINA6_32325;IGFBP3_8881;EGR1_8533;CEBPD_8283;CCND1_8224 98.445755 12.055375000000002 203.5309177080041 60.34119999999999 4.955525 132.28438188524584 205.84743333333333 43.3707 392.43992507750613 3.26713;15.8474;44.9033;8.26335;5.66035;512.733 1.71987;7.7531;18.8755;1.51678;2.15795;330.024 6.6682;40.8362;122.765;45.9052;16.35;1002.56 0 Exp 2,1(0.13);Exp 4,5(0.63);Hill,2(0.25) 2.4092946446180776 22.63324463367462 1.555469274520874 6.495501518249512 1.9322736410841237 1.8953961730003357 -46.24056405020322 198.88210655020322 -33.39130562706012 125.76891412706013 -73.3284312113559 399.5758062113559 DOWN 0.25 0.75 0.0 GO:0009314 4 response to radiation 159 166 9 7 6 6 5 5 47 161 2334 0.88101 0.24849 0.3848 3.01 25587;24330;58919;25612;114628 id2;egr1;ccnd1;asns;abcg5 ID2_8861;EGR1_8533;CCND1_8224;ASNS_8091;ABCG5_7947 207.98961799999998 154.987 2.99674 224.16113284137847 275.4885045544677 224.31410968899473 131.9561848 53.5946 0.998544 157.80686495760378 184.43475790225966 158.20587294102214 410.11643999999995 462.615 10.914 406.13833744201986 506.5596582558763 405.28449266766745 2.99674;8.26335;512.733;154.987;360.968 0.998544;1.51678;330.024;53.5946;273.647 10.914;45.9052;1002.56;462.615;528.588 2 3 2 25587;25612 ID2_8861;ASNS_8091 78.99186999999999 78.99186999999999 107.47334352030649 27.296572 27.296572 37.19102786126739 236.7645 236.7645 319.4008401687447 2.99674;154.987 0.998544;53.5946 10.914;462.615 3 24330;58919;114628 EGR1_8533;CCND1_8224;ABCG5_7947 293.98811666666666 360.968 258.8187310093511 201.72925999999998 273.647 175.66550427748413 525.6844 528.588 478.33400962139416 8.26335;512.733;360.968 1.51678;330.024;273.647 45.9052;1002.56;528.588 0 Exp 2,1(0.2);Exp 4,1(0.2);Hill,2(0.4);Linear,1(0.2) 2.4716444609586827 13.609079241752625 1.555469274520874 5.289852619171143 1.486721010529166 2.1518702507019043 11.503721868900328 404.47551413109966 -6.367631125641964 270.2800007256419 54.12049113067104 766.1123888693289 DOWN 0.4 0.6 0.0 GO:0022414 2 reproductive process 343 368 18 18 10 12 7 7 45 361 2134 0.51631 0.64198 1.0 1.9 29200;24484;116686;24330;24296;58919;24188 inhba;igfbp3;gsr;egr1;cyp1a1;ccnd1;aldh1a1 INHBA_33300;IGFBP3_8881;GSR_8755;EGR1_8533;CYP1A1_8415;CCND1_8224;ALDH1A1_8022 137.15967857142854 88.5069 8.26335 170.20592737163966 134.29715458014448 169.2175686289401 90.88265428571428 65.9487 1.51678 109.86367216440851 88.65900388167515 109.47672800811573 257.4456 133.645 45.9052 333.28766065955693 252.4404012253848 331.384940666824 130.168;44.9033;74.6342;8.26335;100.909;512.733;88.5069 89.164;18.8755;57.2867;1.51678;73.3629;330.024;65.9487 231.33;122.765;106.529;45.9052;159.385;1002.56;133.645 3 4 3 116686;24296;24188 GSR_8755;CYP1A1_8415;ALDH1A1_8022 88.0167 88.5069 13.14425733124555 65.53276666666666 65.9487 8.046166914334641 133.18633333333332 133.645 26.43098494822578 74.6342;100.909;88.5069 57.2867;73.3629;65.9487 106.529;159.385;133.645 4 29200;24484;24330;58919 INHBA_33300;IGFBP3_8881;EGR1_8533;CCND1_8224 174.0169125 87.53565 231.51377458874293 109.89507 54.01975 151.56620000580472 350.64005 177.0475 441.21985315563103 130.168;44.9033;8.26335;512.733 89.164;18.8755;1.51678;330.024 231.33;122.765;45.9052;1002.56 0 Exp 2,1(0.15);Exp 4,1(0.15);Hill,1(0.15);Poly 2,4(0.58) 2.178722592852502 16.802115082740784 1.555469274520874 5.289852619171143 1.3416360538928536 1.9061951637268066 11.069363032974152 263.249994109883 9.494506978855114 172.27080159257343 10.542645757531488 504.34855424246854 CONFLICT 0.42857142857142855 0.5714285714285714 0.0 GO:0019222 4 regulation of metabolic process 1092 1179 60 56 29 44 24 24 28 1155 1340 0.54925 0.56231 1.0 2.04 24522;308843;246273;170698;299270;363140;360918;24614;316351;83619;59107;24539;29200;24484;494344;25587;297417;289388;246248;24330;289185;25695;58919;24188 zfp354a;tsku;trib3;slco1a2;serpina6;rassf1;pf4;orm1;npas2;nfe2l2;ltbp1;lpl;inhba;igfbp3;ier2;id2;gfpt1;g0s2;fmo5;egr1;creg1;cebpd;ccnd1;aldh1a1 ZFP354A_10203;TSKU_10094;TRIB3_10079;SLCO1A2_9886;SERPINA6_32325;RASSF1_32475;PF4_32963;ORM1_9400;NPAS2_9350;NFE2L2_9301;LTBP1_33264;LPL_32544;INHBA_33300;IGFBP3_8881;IER2_32643;ID2_8861;GFPT1_8705;G0S2_32729;FMO5_33281;EGR1_8533;CREG1_8380;CEBPD_8283;CCND1_8224;ALDH1A1_8022 244.13242374999996 73.00235 2.99674 332.3875010437015 283.81824202884184 344.7344035076028 143.08292183333336 44.1369 0.998544 190.72524279430974 163.0135547886413 196.21415886236431 716.1191625 140.53300000000002 6.6682 1319.2803291213872 785.2212064100518 1318.3350350260257 3.26713;6.12626;16.8949;440.994;15.8474;756.581;179.631;56.9823;134.458;6.6423;998.777;769.435;130.168;44.9033;543.54;2.99674;981.5;3.45084;57.4978;8.26335;94.3216;5.66035;512.733;88.5069 1.71987;1.46625;6.46469;299.351;7.7531;437.5;110.795;16.0812;56.7249;3.4063;507.146;444.211;89.164;18.8755;375.947;0.998544;554.87;1.07374;31.5489;1.51678;69.2457;2.15795;330.024;65.9487 6.6682;41.3339;58.9909;772.521;40.8362;940.187;426.677;262.985;320.448;13.4683;5065.92;2183.16;231.33;122.765;978.946;10.914;4240.48;14.3222;109.026;45.9052;147.421;16.35;1002.56;133.645 11 13 11 246273;363140;360918;24614;83619;25587;297417;289388;246248;289185;24188 TRIB3_10079;RASSF1_32475;PF4_32963;ORM1_9400;NFE2L2_9301;ID2_8861;GFPT1_8705;G0S2_32729;FMO5_33281;CREG1_8380;ALDH1A1_8022 204.0913981818182 57.4978 336.67068931331534 117.99388854545454 31.5489 192.0593775474593 578.0105818181818 133.645 1244.8792795460051 16.8949;756.581;179.631;56.9823;6.6423;2.99674;981.5;3.45084;57.4978;94.3216;88.5069 6.46469;437.5;110.795;16.0812;3.4063;0.998544;554.87;1.07374;31.5489;69.2457;65.9487 58.9909;940.187;426.677;262.985;13.4683;10.914;4240.48;14.3222;109.026;147.421;133.645 13 24522;308843;170698;299270;316351;59107;24539;29200;24484;494344;24330;25695;58919 ZFP354A_10203;TSKU_10094;SLCO1A2_9886;SERPINA6_32325;NPAS2_9350;LTBP1_33264;LPL_32544;INHBA_33300;IGFBP3_8881;IER2_32643;EGR1_8533;CEBPD_8283;CCND1_8224 278.01329153846154 130.168 338.5068741896013 164.31210384615386 56.7249 194.72198188613686 832.9802692307693 231.33 1418.5356525898749 3.26713;6.12626;440.994;15.8474;134.458;998.777;769.435;130.168;44.9033;543.54;8.26335;5.66035;512.733 1.71987;1.46625;299.351;7.7531;56.7249;507.146;444.211;89.164;18.8755;375.947;1.51678;2.15795;330.024 6.6682;41.3339;772.521;40.8362;320.448;5065.92;2183.16;231.33;122.765;978.946;45.9052;16.35;1002.56 0 Exp 2,4(0.17);Exp 4,8(0.34);Exp 5,1(0.05);Hill,4(0.17);Linear,2(0.09);Poly 2,5(0.21) 1.9985612637424763 52.19616258144379 1.5232417583465576 6.495501518249512 1.2003114362759237 1.7516418099403381 111.14972725880628 377.1151202411937 66.77693260063282 219.3889110660339 188.29710227371913 1243.9412227262806 CONFLICT 0.4583333333333333 0.5416666666666666 0.0 GO:0010033 4 response to organic substance 795 856 60 54 32 42 26 26 26 830 1665 0.99549 0.0099477 0.016721 3.04 24522;286954;246273;170698;360918;24614;24314;83619;25333;59107;24539;29200;24484;494344;25587;24424;116686;297417;25315;24330;24296;58919;54232;25612;24188;140668 zfp354a;ugt2b1;trib3;slco1a2;pf4;orm1;nqo1;nfe2l2;mgp;ltbp1;lpl;inhba;igfbp3;ier2;id2;gstm2;gsr;gfpt1;ephx1;egr1;cyp1a1;ccnd1;car3;asns;aldh1a1;abcc3 ZFP354A_10203;UGT2B10_33303,UGT2B1_33224;TRIB3_10079;SLCO1A2_9886;PF4_32963;ORM1_9400;NQO1_33055;NFE2L2_9301;MGP_33209;LTBP1_33264;LPL_32544;INHBA_33300;IGFBP3_8881;IER2_32643;ID2_8861;GSTM2_8759;GSR_8755;GFPT1_8705;EPHX1_8567;EGR1_8533;CYP1A1_8415;CCND1_8224;CAR3_8196;ASNS_8091;ALDH1A1_8022;ABCC3_7941 208.08988076923077 74.86735 2.99674 303.3432071472509 218.75337338671824 304.6245872799204 120.53288311538464 32.55545 0.808077 174.85930028393892 124.71042076629097 173.38151373737992 653.9210634615384 128.205 6.6682 1274.3368675345966 685.5528893341711 1279.4711010911867 3.26713;25.4966;16.8949;440.994;179.631;56.9823;24.1117;6.6423;75.1005;998.777;769.435;130.168;44.9033;543.54;2.99674;3.28268;74.6342;981.5;24.8784;8.26335;100.909;512.733;55.21;154.987;88.5069;86.4919 1.71987;11.3392;6.46469;299.351;110.795;16.0812;16.4151;3.4063;13.9312;507.146;444.211;89.164;18.8755;375.947;0.998544;0.808077;57.2867;554.87;15.4867;1.51678;73.3629;330.024;24.6611;53.5946;65.9487;40.4498 6.6682;63.97775;58.9909;772.521;426.677;262.985;37.0434;13.4683;346.231;5065.92;2183.16;231.33;122.765;978.946;10.914;13.1174;106.529;4240.48;41.3795;45.9052;159.385;1002.56;106.714;462.615;133.645;108.02 16 11 15 286954;246273;360918;24614;24314;83619;25587;24424;116686;297417;25315;24296;25612;24188;140668 UGT2B10_33303,UGT2B1_33224;TRIB3_10079;PF4_32963;ORM1_9400;NQO1_33055;NFE2L2_9301;ID2_8861;GSTM2_8759;GSR_8755;GFPT1_8705;EPHX1_8567;CYP1A1_8415;ASNS_8091;ALDH1A1_8022;ABCC3_7941 121.86304133333333 56.9823 243.98263932836994 68.4871674 16.4151 138.42792556109677 409.28181666666666 106.529 1069.4335952077565 25.4966;16.8949;179.631;56.9823;24.1117;6.6423;2.99674;3.28268;74.6342;981.5;24.8784;100.909;154.987;88.5069;86.4919 11.3392;6.46469;110.795;16.0812;16.4151;3.4063;0.998544;0.808077;57.2867;554.87;15.4867;73.3629;53.5946;65.9487;40.4498 63.97775;58.9909;426.677;262.985;37.0434;13.4683;10.914;13.1174;106.529;4240.48;41.3795;159.385;462.615;133.645;108.02 11 24522;170698;25333;59107;24539;29200;24484;494344;24330;58919;54232 ZFP354A_10203;SLCO1A2_9886;MGP_33209;LTBP1_33264;LPL_32544;INHBA_33300;IGFBP3_8881;IER2_32643;EGR1_8533;CCND1_8224;CAR3_8196 325.6719345454545 130.168 346.90563360796443 191.50431363636363 89.164 200.0211421389257 987.5200363636363 346.231 1498.8272034194356 3.26713;440.994;75.1005;998.777;769.435;130.168;44.9033;543.54;8.26335;512.733;55.21 1.71987;299.351;13.9312;507.146;444.211;89.164;18.8755;375.947;1.51678;330.024;24.6611 6.6682;772.521;346.231;5065.92;2183.16;231.33;122.765;978.946;45.9052;1002.56;106.714 0 Exp 2,4(0.15);Exp 4,10(0.38);Exp 5,2(0.08);Hill,4(0.15);Linear,2(0.08);Poly 2,5(0.19) 2.1584928993928627 63.926249504089355 1.5232417583465576 6.495501518249512 1.254381548720686 1.8597915172576904 91.48850585319559 324.691255685266 53.31913199266421 187.74663423810503 164.0817416645677 1143.7603852585094 CONFLICT 0.5769230769230769 0.4230769230769231 0.0 GO:0070328 8 triglyceride homeostasis 18 18 4 4 2 3 2 2 50 16 2479 0.99472 0.050784 0.050784 11.11 24539;114628 lpl;abcg5 LPL_32544;ABCG5_7947 565.2015 565.2015 360.968 288.8297855909253 579.4039724934509 288.1305686570681 358.929 358.929 273.647 120.60696102630244 364.8595415575137 120.31498826692055 1355.8739999999998 1355.8739999999998 528.588 1169.9590811613882 1413.4037718504405 1167.1267721604506 0.0 360.968 0.5 565.2015 769.435;360.968 444.211;273.647 2183.16;528.588 0 2 0 2 24539;114628 LPL_32544;ABCG5_7947 565.2015 565.2015 288.8297855909253 358.929 358.929 120.60696102630244 1355.8739999999998 1355.8739999999998 1169.9590811613882 769.435;360.968 444.211;273.647 2183.16;528.588 0 Exp 2,1(0.5);Linear,1(0.5) 1.907130287019246 3.842095732688904 1.6902254819869995 2.1518702507019043 0.32643214645760454 1.921047866344452 164.90384000000012 965.4991599999998 191.77627999999996 526.08172 -265.60655999999994 2977.3545599999998 DOWN 0.0 1.0 0.0 GO:0044057 5 regulation of system process 160 167 11 10 3 8 2 2 50 165 2330 0.32599 0.86599 0.5784 1.2 29200;114628 inhba;abcg5 INHBA_33300;ABCG5_7947 245.568 245.568 130.168 163.20024509785515 298.1515320417288 145.27306810291086 181.4055 181.4055 89.164 130.44918031363784 223.43655607302534 116.11963354778712 379.959 379.959 231.33 210.1931475619507 447.6837641579732 187.10390675101817 130.168;360.968 89.164;273.647 231.33;528.588 0 2 0 2 29200;114628 INHBA_33300;ABCG5_7947 245.568 245.568 163.20024509785515 181.4055 181.4055 130.44918031363784 379.959 379.959 210.1931475619507 130.168;360.968 89.164;273.647 231.33;528.588 0 Linear,1(0.5);Poly 2,1(0.5) 1.8761427506176935 3.7876155376434326 1.6357452869415283 2.1518702507019043 0.36495546181462296 1.8938077688217163 19.384000000000015 471.752 0.6121600000000456 362.19884 88.64616000000007 671.2718399999999 DOWN 0.0 1.0 0.0 GO:2001233 6 regulation of apoptotic signaling pathway 139 145 7 7 5 4 4 4 48 141 2354 0.82895 0.34332 0.53671 2.76 360918;83619;29200;289388 pf4;nfe2l2;inhba;g0s2 PF4_32963;NFE2L2_9301;INHBA_33300;G0S2_32729 79.97303500000001 68.40515 3.45084 88.85247609108536 69.52178622342939 80.70857714614672 51.10976 46.28515 1.07374 57.124648647343115 45.52850025271611 53.428863467178786 171.449375 122.82610000000001 13.4683 198.6402099233415 138.08421893008975 168.26131945832813 179.631;6.6423;130.168;3.45084 110.795;3.4063;89.164;1.07374 426.677;13.4683;231.33;14.3222 3 1 3 360918;83619;289388 PF4_32963;NFE2L2_9301;G0S2_32729 63.24138 6.6423 100.80899804601373 38.42501333333333 3.4063 62.68509740471441 151.48916666666668 14.3222 238.32003691952414 179.631;6.6423;3.45084 110.795;3.4063;1.07374 426.677;13.4683;14.3222 1 29200 INHBA_33300 130.168 130.168 89.164 89.164 231.33 231.33 130.168 89.164 231.33 0 Exp 4,2(0.5);Poly 2,2(0.5) 1.7676147577698533 7.118475437164307 1.5423688888549805 2.0805697441101074 0.24082237122779823 1.7477684020996094 -7.102391569263673 167.04846156926368 -4.872395674396259 107.09191567439625 -23.21803072487461 366.1167807248747 UP 0.75 0.25 0.0 GO:0051188 5 cofactor biosynthetic process 48 53 6 5 3 4 2 2 50 51 2444 0.90786 0.29493 0.29493 3.77 24296;64392 cyp1a1;aldh1l1 CYP1A1_8415;ALDH1L1_32662 142.4695 142.4695 100.909 58.77542275900694 118.5689880639771 48.084107342156685 92.25845 92.25845 73.3629 26.722343078498945 81.3920427548341 21.861518857787768 654.7275 654.7275 159.385 700.5200815197948 369.867131773693 573.0946918620391 100.909;184.03 73.3629;111.154 159.385;1150.07 2 0 2 24296;64392 CYP1A1_8415;ALDH1L1_32662 142.4695 142.4695 58.77542275900694 92.25845 92.25845 26.722343078498945 654.7275 654.7275 700.5200815197948 100.909;184.03 73.3629;111.154 159.385;1150.07 0 0 Poly 2,2(1) 1.8323458905824062 3.6675528287887573 1.7613576650619507 1.9061951637268066 0.10241557747601716 1.8337764143943787 61.01092000000003 223.92808 55.223172000000005 129.293728 -316.1437999999998 1625.5987999999998 UP 1.0 0.0 0.0 GO:0010604 6 positive regulation of macromolecule metabolic process 704 754 32 29 17 21 14 14 38 740 1755 0.39933 0.71467 0.75993 1.86 246273;363140;360918;24614;316351;83619;24539;29200;24484;494344;25587;24330;25695;58919 trib3;rassf1;pf4;orm1;npas2;nfe2l2;lpl;inhba;igfbp3;ier2;id2;egr1;cebpd;ccnd1 TRIB3_10079;RASSF1_32475;PF4_32963;ORM1_9400;NPAS2_9350;NFE2L2_9301;LPL_32544;INHBA_33300;IGFBP3_8881;IER2_32643;ID2_8861;EGR1_8533;CEBPD_8283;CCND1_8224 226.34923142857141 93.57515000000001 2.99674 288.0294260465523 286.14965355911795 322.87011157719235 135.27620457142856 37.8002 0.998544 176.91941512615787 166.19471872640602 195.41937755514428 472.4776 247.15750000000003 10.914 615.001626271402 598.2186186150515 699.9393352394262 16.8949;756.581;179.631;56.9823;134.458;6.6423;769.435;130.168;44.9033;543.54;2.99674;8.26335;5.66035;512.733 6.46469;437.5;110.795;16.0812;56.7249;3.4063;444.211;89.164;18.8755;375.947;0.998544;1.51678;2.15795;330.024 58.9909;940.187;426.677;262.985;320.448;13.4683;2183.16;231.33;122.765;978.946;10.914;45.9052;16.35;1002.56 6 8 6 246273;363140;360918;24614;83619;25587 TRIB3_10079;RASSF1_32475;PF4_32963;ORM1_9400;NFE2L2_9301;ID2_8861 169.95470666666668 36.9386 294.94406675581774 95.87428899999999 11.272945 172.53608518655622 285.53703333333334 160.98795 360.48800808845033 16.8949;756.581;179.631;56.9823;6.6423;2.99674 6.46469;437.5;110.795;16.0812;3.4063;0.998544 58.9909;940.187;426.677;262.985;13.4683;10.914 8 316351;24539;29200;24484;494344;24330;25695;58919 NPAS2_9350;LPL_32544;INHBA_33300;IGFBP3_8881;IER2_32643;EGR1_8533;CEBPD_8283;CCND1_8224 268.645125 132.313 295.23326019512814 164.82764125 72.94445 185.84223892927542 612.683025 275.889 746.444126877255 134.458;769.435;130.168;44.9033;543.54;8.26335;5.66035;512.733 56.7249;444.211;89.164;18.8755;375.947;1.51678;2.15795;330.024 320.448;2183.16;231.33;122.765;978.946;45.9052;16.35;1002.56 0 Exp 2,2(0.15);Exp 4,5(0.36);Hill,3(0.22);Linear,1(0.08);Poly 2,3(0.22) 1.898300349472394 28.292084455490112 1.5423688888549805 5.289852619171143 0.9707122270492318 1.672523558139801 75.47019128802364 377.2282715691192 42.6001474655566 227.95226167730047 150.3200471057071 794.6351528942929 CONFLICT 0.42857142857142855 0.5714285714285714 0.0 GO:0006357 8 regulation of transcription by RNA polymerase II 343 364 24 21 12 17 11 11 41 353 2142 0.94199 0.11273 0.16014 3.02 24522;246273;360918;316351;83619;29200;494344;25587;24330;25695;58919 zfp354a;trib3;pf4;npas2;nfe2l2;inhba;ier2;id2;egr1;cebpd;ccnd1 ZFP354A_10203;TRIB3_10079;PF4_32963;NPAS2_9350;NFE2L2_9301;INHBA_33300;IER2_32643;ID2_8861;EGR1_8533;CEBPD_8283;CCND1_8224 140.38679727272728 16.8949 2.99674 202.30604850183724 148.67131517915715 211.62638776868425 88.99263945454545 6.46469 0.998544 136.6174115723358 91.85967636724104 141.90908223807344 282.9325090909091 58.9909 6.6682 377.8036839822673 299.6485693232302 398.1517425153273 3.26713;16.8949;179.631;134.458;6.6423;130.168;543.54;2.99674;8.26335;5.66035;512.733 1.71987;6.46469;110.795;56.7249;3.4063;89.164;375.947;0.998544;1.51678;2.15795;330.024 6.6682;58.9909;426.677;320.448;13.4683;231.33;978.946;10.914;45.9052;16.35;1002.56 4 7 4 246273;360918;83619;25587 TRIB3_10079;PF4_32963;NFE2L2_9301;ID2_8861 51.541235 11.7686 85.59563615361611 30.4161335 4.9354949999999995 53.632575621061825 127.51255 36.229600000000005 200.66215178975995 16.8949;179.631;6.6423;2.99674 6.46469;110.795;3.4063;0.998544 58.9909;426.677;13.4683;10.914 7 24522;316351;29200;494344;24330;25695;58919 ZFP354A_10203;NPAS2_9350;INHBA_33300;IER2_32643;EGR1_8533;CEBPD_8283;CCND1_8224 191.15569 130.168 237.234425128096 122.46492857142857 56.7249 161.4756043357438 371.74391428571425 231.33 438.6962928646326 3.26713;134.458;130.168;543.54;8.26335;5.66035;512.733 1.71987;56.7249;89.164;375.947;1.51678;2.15795;330.024 6.6682;320.448;231.33;978.946;45.9052;16.35;1002.56 0 Exp 2,1(0.1);Exp 4,4(0.37);Hill,3(0.28);Linear,1(0.1);Poly 2,2(0.19) 2.1794010736902814 27.66316068172455 1.5423688888549805 6.495501518249512 1.7065819808580325 1.8597915172576904 20.83156262072096 259.9420319247336 8.256908520964402 169.7283703881265 59.66479947281434 506.2002187090038 DOWN 0.36363636363636365 0.6363636363636364 0.0 GO:1902168 6 response to catechin 1 1 1 1 1 1 1 1 51 0 2495 1.0 0.020416 0.020416 100.0 24424 gstm2 GSTM2_8759 3.28268 3.28268 3.28268 3.28268 0.808077 0.808077 0.808077 0.808077 13.1174 13.1174 13.1174 13.1174 0.0 3.28268 0.0 3.28268 3.28268 0.808077 13.1174 1 0 1 24424 GSTM2_8759 3.28268 3.28268 0.808077 0.808077 13.1174 13.1174 3.28268 0.808077 13.1174 0 0 Hill,1(1) 1.7059084177017212 1.7059084177017212 1.7059084177017212 1.7059084177017212 0.0 1.7059084177017212 3.28268 3.28268 0.808077 0.808077 13.1174 13.1174 UP 1.0 0.0 0.0 GO:0044281 3 small molecule metabolic process 449 498 52 48 25 40 19 19 33 479 2016 0.9989 0.0029238 0.003956 3.82 286954;305291;266730;501907;24539;24424;297417;25598;25315;499353;29277;24296;290277;54232;25612;64392;24188;24763;296925 ugt2b1;srd5a3;slc17a3;rgd1559459;lpl;gstm2;gfpt1;fabp2;ephx1;cyp2c24;cyp2c11;cyp1a1;cryl1;car3;asns;aldh1l1;aldh1a1;acsm3;aass UGT2B10_33303,UGT2B1_33224;SRD5A3_9939;SLC17A3_9840;RGD1559459_9690;LPL_32544;GSTM2_8759;GFPT1_8705;FABP2_32859;EPHX1_8567;CYP2C24_32875;CYP2C11_32593;CYP1A1_8415;CRYL1_8388;CAR3_8196;ASNS_8091;ALDH1L1_32662;ALDH1A1_8022;ACSM3_7976;AASS_7936 222.85399368421054 100.909 3.28268 290.7141572476325 243.22778769750312 288.4970298165966 131.25529984210525 53.5946 0.808077 175.43965947241364 148.67508063722994 176.01951744385076 671.152197368421 250.463 13.1174 1053.8615145560914 632.3643988503242 840.4726679066135 25.4966;169.209;58.7587;42.78;769.435;3.28268;981.5;146.645;24.8784;733.935;129.934;100.909;76.0301;55.21;154.987;184.03;88.5069;460.125;28.5735 11.3392;105.547;46.6655;20.6065;444.211;0.808077;554.87;95.8536;15.4867;463.206;45.3106;73.3629;23.2788;24.6611;53.5946;111.154;65.9487;331.8;6.14642 63.97775;459.211;78.8953;93.6128;2183.16;13.1174;4240.48;319.535;41.3795;1763.75;355.143;159.385;250.463;106.714;462.615;1150.07;133.645;748.659;128.079 14 6 13 286954;305291;266730;501907;24424;297417;25598;25315;24296;290277;25612;64392;24188 UGT2B10_33303,UGT2B1_33224;SRD5A3_9939;SLC17A3_9840;RGD1559459_9690;GSTM2_8759;GFPT1_8705;FABP2_32859;EPHX1_8567;CYP1A1_8415;CRYL1_8388;ASNS_8091;ALDH1L1_32662;ALDH1A1_8022 158.23179846153846 88.5069 254.33589184130835 90.6550443846154 53.5946 144.29212942795144 574.3374423076923 159.385 1142.7327533883763 25.4966;169.209;58.7587;42.78;3.28268;981.5;146.645;24.8784;100.909;76.0301;154.987;184.03;88.5069 11.3392;105.547;46.6655;20.6065;0.808077;554.87;95.8536;15.4867;73.3629;23.2788;53.5946;111.154;65.9487 63.97775;459.211;78.8953;93.6128;13.1174;4240.48;319.535;41.3795;159.385;250.463;462.615;1150.07;133.645 6 24539;499353;29277;54232;24763;296925 LPL_32544;CYP2C24_32875;CYP2C11_32593;CAR3_8196;ACSM3_7976;AASS_7936 362.8687499999999 295.0295 338.5589680022891 219.22252000000003 188.55530000000002 217.40394205739878 880.9174999999999 551.901 887.1659094024637 769.435;733.935;129.934;55.21;460.125;28.5735 444.211;463.206;45.3106;24.6611;331.8;6.14642 2183.16;1763.75;355.143;106.714;748.659;128.079 0 Exp 2,1(0.05);Exp 4,6(0.3);Exp 5,1(0.05);Hill,3(0.15);Linear,3(0.15);Poly 2,6(0.3) 1.9038638782140005 38.851518869400024 1.5232417583465576 2.79919695854187 0.422834966026582 1.733633041381836 92.13296629041665 353.5750210780044 52.368008115489474 210.14259156872112 197.27826835915914 1145.0261263776824 UP 0.6842105263157895 0.3157894736842105 0.0 GO:0045667 6 regulation of osteoblast differentiation 33 34 3 3 3 2 2 2 50 32 2463 0.96923 0.15188 0.15188 5.88 25587;25695 id2;cebpd ID2_8861;CEBPD_8283 4.328545 4.328545 2.99674 1.8834566934362993 4.964995125621566 1.6544701844525869 1.578247 1.578247 0.998544 0.8198238447483707 1.8552785828317193 0.7201514706264961 13.632000000000001 13.632000000000001 10.914 3.8438324625300684 14.930892436534942 3.376507793064382 0.5 4.328545 2.99674;5.66035 0.998544;2.15795 10.914;16.35 1 1 1 25587 ID2_8861 2.99674 2.99674 0.998544 0.998544 10.914 10.914 2.99674 0.998544 10.914 1 25695 CEBPD_8283 5.66035 5.66035 2.15795 2.15795 16.35 16.35 5.66035 2.15795 16.35 0 Exp 4,1(0.5);Hill,1(0.5) 1.7663711076204096 3.5553308725357056 1.577596664428711 1.9777342081069946 0.28293997054224274 1.7776654362678528 1.7182072000000002 6.9388828 0.44202911999999994 2.7144648800000004 8.30472 18.959280000000003 CONFLICT 0.5 0.5 0.0 GO:0065008 3 regulation of biological quality 821 880 59 53 25 42 19 19 33 861 1634 0.67832 0.43198 0.76944 2.16 299270;363140;24314;83619;59107;24539;29200;24484;25587;24424;116686;289388;24330;499353;24296;58919;117517;24188;114628 serpina6;rassf1;nqo1;nfe2l2;ltbp1;lpl;inhba;igfbp3;id2;gstm2;gsr;g0s2;egr1;cyp2c24;cyp1a1;ccnd1;c7;aldh1a1;abcg5 SERPINA6_32325;RASSF1_32475;NQO1_33055;NFE2L2_9301;LTBP1_33264;LPL_32544;INHBA_33300;IGFBP3_8881;ID2_8861;GSTM2_8759;GSR_8755;G0S2_32729;EGR1_8533;CYP2C24_32875;CYP1A1_8415;CCND1_8224;C7_8179;ALDH1A1_8022;ABCG5_7947 244.7362268421053 74.6342 2.99674 333.2956749643317 358.580349889847 356.91679869568014 147.24591057894736 57.2867 0.808077 190.61793182974966 215.34165634567916 201.5635744872762 655.5432631578948 122.765 10.914 1239.9553305936715 938.9784320141446 1370.1751802712074 15.8474;756.581;24.1117;6.6423;998.777;769.435;130.168;44.9033;2.99674;3.28268;74.6342;3.45084;8.26335;733.935;100.909;512.733;13.8429;88.5069;360.968 7.7531;437.5;16.4151;3.4063;507.146;444.211;89.164;18.8755;0.998544;0.808077;57.2867;1.07374;1.51678;463.206;73.3629;330.024;5.32886;65.9487;273.647 40.8362;940.187;37.0434;13.4683;5065.92;2183.16;231.33;122.765;10.914;13.1174;106.529;14.3222;45.9052;1763.75;159.385;1002.56;41.8963;133.645;528.588 9 10 9 363140;24314;83619;25587;24424;116686;289388;24296;24188 RASSF1_32475;NQO1_33055;NFE2L2_9301;ID2_8861;GSTM2_8759;GSR_8755;G0S2_32729;CYP1A1_8415;ALDH1A1_8022 117.90170666666667 24.1117 242.78360170286706 72.97778455555556 16.4151 139.98723609721608 158.73458888888888 37.0434 298.71484631093597 756.581;24.1117;6.6423;2.99674;3.28268;74.6342;3.45084;100.909;88.5069 437.5;16.4151;3.4063;0.998544;0.808077;57.2867;1.07374;73.3629;65.9487 940.187;37.0434;13.4683;10.914;13.1174;106.529;14.3222;159.385;133.645 10 299270;59107;24539;29200;24484;24330;499353;58919;117517;114628 SERPINA6_32325;LTBP1_33264;LPL_32544;INHBA_33300;IGFBP3_8881;EGR1_8533;CYP2C24_32875;CCND1_8224;C7_8179;ABCG5_7947 358.887295 245.568 373.1114644093359 214.08722400000002 181.4055 211.59256287709226 1102.6710699999999 379.959 1589.561750657874 15.8474;998.777;769.435;130.168;44.9033;8.26335;733.935;512.733;13.8429;360.968 7.7531;507.146;444.211;89.164;18.8755;1.51678;463.206;330.024;5.32886;273.647 40.8362;5065.92;2183.16;231.33;122.765;45.9052;1763.75;1002.56;41.8963;528.588 0 Exp 2,3(0.16);Exp 4,5(0.27);Hill,4(0.22);Linear,2(0.11);Poly 2,5(0.27) 2.089222294899862 42.54119527339935 1.5423688888549805 5.289852619171143 1.039578136780105 1.9061951637268066 94.86821398116555 394.604239703045 61.53363524851028 232.95818590938433 97.99134937356484 1213.0951769422245 CONFLICT 0.47368421052631576 0.5263157894736842 0.0 GO:0045639 7 positive regulation of myeloid cell differentiation 40 45 6 6 3 4 3 3 49 42 2453 0.98759 0.062447 0.062447 6.67 360918;29200;25587 pf4;inhba;id2 PF4_32963;INHBA_33300;ID2_8861 104.26524666666667 130.168 2.99674 91.12151186258124 95.8057242408907 83.77800473497292 66.98584799999999 89.164 0.998544 58.16114043879567 63.18202568825912 55.05495779336463 222.97366666666667 231.33 10.914 208.00742600285534 190.46729706477734 178.2771414812743 1.5 154.8995 179.631;130.168;2.99674 110.795;89.164;0.998544 426.677;231.33;10.914 2 1 2 360918;25587 PF4_32963;ID2_8861 91.31387 91.31387 124.89928303586774 55.896772 55.896772 77.6378185878504 218.7955 218.7955 293.9888366664626 179.631;2.99674 110.795;0.998544 426.677;10.914 1 29200 INHBA_33300 130.168 130.168 89.164 89.164 231.33 231.33 130.168 89.164 231.33 0 Hill,1(0.34);Poly 2,2(0.67) 1.8187902686165627 5.473271012306213 1.6357452869415283 1.9777342081069946 0.1737160584802956 1.8597915172576904 1.151549037125804 207.37894429620752 1.1703218261199595 132.80137417388005 -12.408894389865111 458.3562277231985 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0030178 7 negative regulation of Wnt signaling pathway 31 31 3 3 2 3 2 2 50 29 2466 0.97588 0.13074 0.13074 6.45 308843;24330 tsku;egr1 TSKU_10094;EGR1_8533 7.194805000000001 7.194805000000001 6.12626 1.511150831005962 7.208366308420629 1.5110291247616103 1.4915150000000001 1.4915150000000001 1.46625 0.03573010565334971 1.491835647663175 0.03572722799424558 43.619550000000004 43.619550000000004 41.3339 3.2323972288379332 43.64855804794521 3.232136895508677 0.5 7.194805000000001 6.12626;8.26335 1.46625;1.51678 41.3339;45.9052 0 2 0 2 308843;24330 TSKU_10094;EGR1_8533 7.194805000000001 7.194805000000001 1.511150831005962 1.4915150000000001 1.4915150000000001 0.03573010565334971 43.619550000000004 43.619550000000004 3.2323972288379332 6.12626;8.26335 1.46625;1.51678 41.3339;45.9052 0 Hill,2(1) 3.5369383220482185 7.654745101928711 2.3648924827575684 5.289852619171143 2.0682591471583676 3.8273725509643555 5.1004568 9.289153200000001 1.4419956000000003 1.5410344 39.139676 48.099424000000006 DOWN 0.0 1.0 0.0 GO:1901654 5 response to ketone 140 154 10 9 4 7 3 3 49 151 2344 0.61384 0.61837 1.0 1.95 286954;24424;58919 ugt2b1;gstm2;ccnd1 UGT2B10_33303,UGT2B1_33224;GSTM2_8759;CCND1_8224 180.50409333333332 25.4966 3.28268 287.9329772345261 292.99699784640006 299.45833048649746 114.05709233333333 11.3392 0.808077 187.10693478125597 186.65686901301763 195.35503233245691 359.88505000000004 63.97775 13.1174 557.1534908072078 578.5581890150397 577.9029022358703 25.4966;3.28268;512.733 11.3392;0.808077;330.024 63.97775;13.1174;1002.56 3 1 2 286954;24424 UGT2B10_33303,UGT2B1_33224;GSTM2_8759 14.38964 14.38964 15.707613468735476 6.0736385 6.0736385 7.446628486809618 38.547575 38.547575 35.963698378521215 25.4966;3.28268 11.3392;0.808077 63.97775;13.1174 1 58919 CCND1_8224 512.733 512.733 330.024 330.024 1002.56 1002.56 512.733 330.024 1002.56 0 Exp 2,1(0.25);Exp 4,2(0.5);Hill,1(0.25) 1.6644120128798634 6.662665605545044 1.555469274520874 1.7059084177017212 0.07352425041882626 1.7006439566612244 -145.32274321991775 506.33092988658444 -97.6743364265463 325.788521093213 -270.59347707906306 990.363577079063 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0045892 8 negative regulation of transcription, DNA-templated 221 232 16 14 7 11 6 6 46 226 2269 0.81015 0.33486 0.46828 2.59 24522;246273;25587;24330;25695;58919 zfp354a;trib3;id2;egr1;cebpd;ccnd1 ZFP354A_10203;TRIB3_10079;ID2_8861;EGR1_8533;CEBPD_8283;CCND1_8224 91.63591166666667 6.96185 2.99674 206.35779713765731 121.2120189809665 232.28122151907968 57.14697233333334 1.93891 0.998544 133.6965867360145 76.54801409755086 150.367169684648 190.23138333333335 31.1276 6.6682 398.50139142231563 245.74047337041 449.31800781922897 3.26713;16.8949;2.99674;8.26335;5.66035;512.733 1.71987;6.46469;0.998544;1.51678;2.15795;330.024 6.6682;58.9909;10.914;45.9052;16.35;1002.56 2 4 2 246273;25587 TRIB3_10079;ID2_8861 9.94582 9.94582 9.827483182015628 3.731617 3.731617 3.865148903555722 34.95245 34.95245 33.995502008427536 16.8949;2.99674 6.46469;0.998544 58.9909;10.914 4 24522;24330;25695;58919 ZFP354A_10203;EGR1_8533;CEBPD_8283;CCND1_8224 132.4809575 6.96185 253.50957216793915 83.85465 1.93891 164.11311809449987 267.87084999999996 31.1276 490.0770209056905 3.26713;8.26335;5.66035;512.733 1.71987;1.51678;2.15795;330.024 6.6682;45.9052;16.35;1002.56 0 Exp 2,1(0.17);Exp 4,3(0.5);Hill,2(0.34) 2.6894247688335295 19.165364861488342 1.555469274520874 6.495501518249512 2.1412422002567704 2.1234723925590515 -73.48471542779436 256.7565387611277 -49.83257749929641 164.12652216596308 -128.63613978610363 509.0989064527703 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0006066 4 alcohol metabolic process 93 100 14 14 4 14 4 4 48 96 2399 0.94906 0.14496 0.14496 4.0 305291;25315;24296;24188 srd5a3;ephx1;cyp1a1;aldh1a1 SRD5A3_9939;EPHX1_8567;CYP1A1_8415;ALDH1A1_8022 95.875825 94.70795000000001 24.8784 59.15522749075099 109.97916696562034 45.58090189552044 65.08632499999999 69.6558 15.4867 37.26676090909747 75.70120918036872 26.00022470022405 198.405125 146.515 41.3795 181.101440530059 221.64544103969442 164.9162934053062 169.209;24.8784;100.909;88.5069 105.547;15.4867;73.3629;65.9487 459.211;41.3795;159.385;133.645 4 0 4 305291;25315;24296;24188 SRD5A3_9939;EPHX1_8567;CYP1A1_8415;ALDH1A1_8022 95.875825 94.70795000000001 59.15522749075099 65.08632499999999 69.6558 37.26676090909747 198.405125 146.515 181.101440530059 169.209;24.8784;100.909;88.5069 105.547;15.4867;73.3629;65.9487 459.211;41.3795;159.385;133.645 0 0 Exp 4,1(0.25);Poly 2,3(0.75) 2.154770408135457 8.874518632888794 1.5321133136749268 2.79919695854187 0.6002841494814447 2.2716041803359985 37.90370205906404 153.84794794093594 28.564899309084502 101.60775069091551 20.92571328054217 375.88453671945786 UP 1.0 0.0 0.0 GO:0001817 5 regulation of cytokine production 196 207 10 9 5 6 5 5 47 202 2293 0.75597 0.41734 0.60905 2.42 360918;24614;59107;24539;24330 pf4;orm1;ltbp1;lpl;egr1 PF4_32963;ORM1_9400;LTBP1_33264;LPL_32544;EGR1_8533 402.61773 179.631 8.26335 451.29344500827506 473.7539936178644 470.06087141246417 215.949996 110.795 1.51678 241.80824614506446 252.23194620621894 256.16770391621395 1596.9294399999999 426.677 45.9052 2117.317672802518 1890.886205502552 2162.7573956652122 179.631;56.9823;998.777;769.435;8.26335 110.795;16.0812;507.146;444.211;1.51678 426.677;262.985;5065.92;2183.16;45.9052 2 3 2 360918;24614 PF4_32963;ORM1_9400 118.30665 118.30665 86.72572747371449 63.4381 63.4381 66.97277025194643 344.831 344.831 115.74772322598835 179.631;56.9823 110.795;16.0812 426.677;262.985 3 59107;24539;24330 LTBP1_33264;LPL_32544;EGR1_8533 592.15845 769.435 518.5070434372203 317.62459333333334 444.211 275.5600039810497 2431.6617333333334 2183.16 2519.216541239957 998.777;769.435;8.26335 507.146;444.211;1.51678 5065.92;2183.16;45.9052 0 Exp 2,2(0.4);Exp 4,1(0.2);Hill,1(0.2);Poly 2,1(0.2) 2.1245809707878114 12.067302703857422 1.5846891403198242 5.289852619171143 1.6112197112397892 1.6902254819869995 7.041584231282059 798.1938757687179 3.9957230470567424 427.9042689529433 -258.9813285684497 3452.8402085684493 DOWN 0.4 0.6 0.0 GO:0044238 3 primary metabolic process 1157 1278 70 66 33 51 25 25 27 1253 1242 0.43417 0.67207 0.78099 1.96 286954;246273;24902;305291;299270;501907;83619;307126;24539;29200;24484;24424;297417;25598;25315;24330;499353;29277;24296;290277;58919;25612;24188;24763;296925 ugt2b1;trib3;sult2a6;srd5a3;serpina6;rgd1559459;nfe2l2;mcm10;lpl;inhba;igfbp3;gstm2;gfpt1;fabp2;ephx1;egr1;cyp2c24;cyp2c11;cyp1a1;cryl1;ccnd1;asns;aldh1a1;acsm3;aass UGT2B10_33303,UGT2B1_33224;TRIB3_10079;SULT2A6_32471,SULT2A6_9972;SRD5A3_9939;SERPINA6_32325;RGD1559459_9690;NFE2L2_9301;MCM10_32579;LPL_32544;INHBA_33300;IGFBP3_8881;GSTM2_8759;GFPT1_8705;FABP2_32859;EPHX1_8567;EGR1_8533;CYP2C24_32875;CYP2C11_32593;CYP1A1_8415;CRYL1_8388;CCND1_8224;ASNS_8091;ALDH1A1_8022;ACSM3_7976;AASS_7936 197.4325992 88.5069 3.28268 272.38958884973397 219.23746135577235 266.93505292151303 116.50471467999999 45.3106 0.808077 165.80935604912645 132.79128291937064 165.16412714930695 550.1809619999999 159.385 13.1174 939.7089313646973 550.2836535580832 741.8963379086979 25.4966;16.8949;50.527550000000005;169.209;15.8474;42.78;6.6423;213.608;769.435;130.168;44.9033;3.28268;981.5;146.645;24.8784;8.26335;733.935;129.934;100.909;76.0301;512.733;154.987;88.5069;460.125;28.5735 11.3392;6.46469;20.8664;105.547;7.7531;20.6065;3.4063;123.177;444.211;89.164;18.8755;0.808077;554.87;95.8536;15.4867;1.51678;463.206;45.3106;73.3629;23.2788;330.024;53.5946;65.9487;331.8;6.14642 63.97775;58.9909;154.361;459.211;40.8362;93.6128;13.4683;668.095;2183.16;231.33;122.765;13.1174;4240.48;319.535;41.3795;45.9052;1763.75;355.143;159.385;250.463;1002.56;462.615;133.645;748.659;128.079 16 11 14 286954;246273;24902;305291;501907;83619;24424;297417;25598;25315;24296;290277;25612;24188 UGT2B10_33303,UGT2B1_33224;TRIB3_10079;SULT2A6_32471,SULT2A6_9972;SRD5A3_9939;RGD1559459_9690;NFE2L2_9301;GSTM2_8759;GFPT1_8705;FABP2_32859;EPHX1_8567;CYP1A1_8415;CRYL1_8388;ASNS_8091;ALDH1A1_8022 134.87781642857144 63.278825000000005 250.01545912148853 75.1023905 22.0726 142.41644234020202 461.73154642857145 144.003 1097.975132483502 25.4966;16.8949;50.527550000000005;169.209;42.78;6.6423;3.28268;981.5;146.645;24.8784;100.909;76.0301;154.987;88.5069 11.3392;6.46469;20.8664;105.547;20.6065;3.4063;0.808077;554.87;95.8536;15.4867;73.3629;23.2788;53.5946;65.9487 63.97775;58.9909;154.361;459.211;93.6128;13.4683;13.1174;4240.48;319.535;41.3795;159.385;250.463;462.615;133.645 11 299270;307126;24539;29200;24484;24330;499353;29277;58919;24763;296925 SERPINA6_32325;MCM10_32579;LPL_32544;INHBA_33300;IGFBP3_8881;EGR1_8533;CYP2C24_32875;CYP2C11_32593;CCND1_8224;ACSM3_7976;AASS_7936 277.0477772727273 130.168 290.44756378592274 169.19858181818182 89.164 184.82771637621917 662.7529454545455 355.143 726.0994265693263 15.8474;213.608;769.435;130.168;44.9033;8.26335;733.935;129.934;512.733;460.125;28.5735 7.7531;123.177;444.211;89.164;18.8755;1.51678;463.206;45.3106;330.024;331.8;6.14642 40.8362;668.095;2183.16;231.33;122.765;45.9052;1763.75;355.143;1002.56;748.659;128.079 0 Exp 2,2(0.08);Exp 4,12(0.45);Hill,4(0.15);Linear,3(0.12);Poly 2,6(0.23) 1.9222833001164519 54.140273213386536 1.5232417583465576 5.289852619171143 0.7472346328542271 1.7045893669128418 90.65588037090426 304.20931802909575 51.50744710874241 181.50198225125757 181.8150609050386 918.5468630949613 CONFLICT 0.56 0.44 0.0 GO:0048870 3 cell motility 193 205 5 5 2 4 2 2 50 203 2292 0.19716 0.93126 0.43428 0.98 360918;494344 pf4;ier2 PF4_32963;IER2_32643 361.58549999999997 361.58549999999997 179.631 257.32252163481525 464.0430252808989 212.64945607061358 243.371 243.371 110.795 187.4907772451754 318.02377787381164 154.94101156067953 702.8115 702.8115 426.677 390.51315493911335 858.3012378997408 322.71722451124236 179.631;543.54 110.795;375.947 426.677;978.946 1 1 1 360918 PF4_32963 179.631 179.631 110.795 110.795 426.677 426.677 179.631 110.795 426.677 1 494344 IER2_32643 543.54 543.54 375.947 375.947 978.946 978.946 543.54 375.947 978.946 0 Linear,1(0.5);Poly 2,1(0.5) 1.709322635371158 3.4308191537857056 1.5710276365280151 1.8597915172576904 0.20418689822569683 1.7154095768928528 4.954680000000053 718.21632 -16.477959999999996 503.21995999999996 161.58788000000015 1244.03512 CONFLICT 0.5 0.5 0.0 GO:0010565 6 regulation of cellular ketone metabolic process 51 56 6 6 2 6 2 2 50 54 2441 0.89545 0.31782 0.31782 3.57 246273;24330 trib3;egr1 TRIB3_10079;EGR1_8533 12.579125000000001 12.579125000000001 8.26335 6.103427537150737 11.020959042913226 5.691754158570247 3.990735 3.990735 1.51678 3.4987007137007304 3.0975391173683495 3.262714960665387 52.44805 52.44805 45.9052 9.252987206572767 50.085821632597806 8.62887747771867 16.8949;8.26335 6.46469;1.51678 58.9909;45.9052 1 1 1 246273 TRIB3_10079 16.8949 16.8949 6.46469 6.46469 58.9909 58.9909 16.8949 6.46469 58.9909 1 24330 EGR1_8533 8.26335 8.26335 1.51678 1.51678 45.9052 45.9052 8.26335 1.51678 45.9052 0 Exp 4,1(0.5);Hill,1(0.5) 3.4646485412308525 7.559063196182251 2.2692105770111084 5.289852619171143 2.1359164715485415 3.7795315980911255 4.120206000000003 21.038044 -0.8582168000000001 8.839686799999999 39.624064 65.272036 CONFLICT 0.5 0.5 0.0 GO:0006996 5 organelle organization 397 425 10 9 4 5 2 2 50 423 2072 0.0045673 0.99921 0.0077836 0.47 24522;29276 zfp354a;csrp1 ZFP354A_10203;CSRP1_8396 188.283065 188.283065 3.26713 261.652044532139 146.62058263491002 254.9318880293432 132.797435 132.797435 1.71987 185.3716701458409 103.28096799800133 180.6106653664127 304.90659999999997 304.90659999999997 6.6682 421.7727901004521 237.74831938707524 410.94016250465387 3.26713;373.299 1.71987;263.875 6.6682;603.145 0 2 0 2 24522;29276 ZFP354A_10203;CSRP1_8396 188.283065 188.283065 261.652044532139 132.797435 132.797435 185.3716701458409 304.90659999999997 304.90659999999997 421.7727901004521 3.26713;373.299 1.71987;263.875 6.6682;603.145 0 Exp 2,1(0.5);Exp 4,1(0.5) 3.430144066738651 8.306891798973083 1.8113902807235718 6.495501518249512 3.3121668198867034 4.153445899486542 -174.34816759999998 550.9142975999999 -124.11459239999996 389.7094623999999 -279.6406639999999 889.453864 DOWN 0.0 1.0 0.0 GO:2000026 5 regulation of multicellular organismal development 487 514 21 20 10 16 8 8 44 506 1989 0.24891 0.8532 0.48553 1.56 360918;338475;83619;25333;29200;25587;24330;58919 pf4;nrep;nfe2l2;mgp;inhba;id2;egr1;ccnd1 PF4_32963;NREP_9364;NFE2L2_9301;MGP_33209;INHBA_33300;ID2_8861;EGR1_8533;CCND1_8224 128.51986125 93.86224999999999 2.99674 168.35885560214018 148.508134799387 190.5960887945324 78.6622155 46.69655 0.998544 110.94581096481343 87.50160145834494 127.87580047250343 283.6780625 211.8345 10.914 328.6738361200092 341.8334879102814 359.9868284904709 179.631;112.624;6.6423;75.1005;130.168;2.99674;8.26335;512.733 110.795;79.4619;3.4063;13.9312;89.164;0.998544;1.51678;330.024 426.677;192.339;13.4683;346.231;231.33;10.914;45.9052;1002.56 3 5 3 360918;83619;25587 PF4_32963;NFE2L2_9301;ID2_8861 63.09001333333333 6.6423 100.94391366921799 38.399948 3.4063 62.70751141451009 150.3531 13.4683 239.3069250889535 179.631;6.6423;2.99674 110.795;3.4063;0.998544 426.677;13.4683;10.914 5 338475;25333;29200;24330;58919 NREP_9364;MGP_33209;INHBA_33300;EGR1_8533;CCND1_8224 167.77776999999998 112.624 198.42156536753254 102.81957600000001 79.4619 132.7754739537008 363.67304 231.33 372.9367258848449 112.624;75.1005;130.168;8.26335;512.733 79.4619;13.9312;89.164;1.51678;330.024 192.339;346.231;231.33;45.9052;1002.56 0 Exp 2,1(0.13);Exp 4,1(0.13);Hill,3(0.38);Poly 2,3(0.38) 2.0238764776927423 17.705928325653076 1.5423688888549805 5.289852619171143 1.2564032888958303 1.8429177403450012 11.85312655030151 245.18659594969847 1.7806909280888163 155.5437400719112 55.91871414732657 511.43741085267345 DOWN 0.375 0.625 0.0 GO:0001775 3 cell activation 161 172 5 4 3 3 3 3 49 169 2326 0.52927 0.69382 1.0 1.74 360918;25587;24330 pf4;id2;egr1 PF4_32963;ID2_8861;EGR1_8533 63.63036333333333 8.26335 2.99674 100.49400517208493 28.523004823851615 70.2754652443193 37.770108 1.51678 0.998544 63.241942418356125 15.141378481264782 44.45289840802943 161.1654 45.9052 10.914 230.60443040037197 85.13747260052284 159.74536235956455 179.631;2.99674;8.26335 110.795;0.998544;1.51678 426.677;10.914;45.9052 2 1 2 360918;25587 PF4_32963;ID2_8861 91.31387 91.31387 124.89928303586774 55.896772 55.896772 77.6378185878504 218.7955 218.7955 293.9888366664626 179.631;2.99674 110.795;0.998544 426.677;10.914 1 24330 EGR1_8533 8.26335 8.26335 1.51678 1.51678 45.9052 45.9052 8.26335 1.51678 45.9052 0 Hill,2(0.67);Poly 2,1(0.34) 2.6896261594033404 9.127378344535828 1.8597915172576904 5.289852619171143 1.9471927660992117 1.9777342081069946 -50.08930890523855 177.3500355719052 -33.794886859452944 109.33510285945293 -99.78807873723119 422.11887873723117 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0015747 6 urate transport 2 2 1 1 1 1 1 1 51 1 2494 0.99959 0.040423 0.040423 50.0 266730 slc17a3 SLC17A3_9840 58.7587 58.7587 58.7587 58.75869999999999 46.6655 46.6655 46.6655 46.6655 78.8953 78.8953 78.8953 78.8953 0.0 58.7587 0.0 58.7587 58.7587 46.6655 78.8953 1 0 1 266730 SLC17A3_9840 58.7587 58.7587 46.6655 46.6655 78.8953 78.8953 58.7587 46.6655 78.8953 0 0 Poly 2,1(1) 1.7953243255615234 1.7953243255615234 1.7953243255615234 1.7953243255615234 0.0 1.7953243255615234 58.7587 58.7587 46.6655 46.6655 78.8953 78.8953 UP 1.0 0.0 0.0 GO:0051716 3 cellular response to stimulus 785 838 56 50 30 38 24 24 28 814 1681 0.98453 0.030523 0.05148 2.86 286954;246273;170698;363140;360918;24614;338475;24314;83619;307126;59107;24539;29200;24484;25587;24424;300850;116686;297417;25315;24330;24296;58919;25612 ugt2b1;trib3;slco1a2;rassf1;pf4;orm1;nrep;nqo1;nfe2l2;mcm10;ltbp1;lpl;inhba;igfbp3;id2;gstm2;gsta4;gsr;gfpt1;ephx1;egr1;cyp1a1;ccnd1;asns UGT2B10_33303,UGT2B1_33224;TRIB3_10079;SLCO1A2_9886;RASSF1_32475;PF4_32963;ORM1_9400;NREP_9364;NQO1_33055;NFE2L2_9301;MCM10_32579;LTBP1_33264;LPL_32544;INHBA_33300;IGFBP3_8881;ID2_8861;GSTM2_8759;GSTA4_8757;GSR_8755;GFPT1_8705;EPHX1_8567;EGR1_8533;CYP1A1_8415;CCND1_8224;ASNS_8091 239.43285291666666 103.132 2.99674 321.1912461404199 287.25934613837046 333.1517016123551 138.624099625 65.3248 0.808077 180.7491116324968 165.51337092417015 186.16811845278366 720.5993937500001 182.19 10.914 1311.0183796643926 806.0281330499731 1305.1755596689065 25.4966;16.8949;440.994;756.581;179.631;56.9823;112.624;24.1117;6.6423;213.608;998.777;769.435;130.168;44.9033;2.99674;3.28268;105.355;74.6342;981.5;24.8784;8.26335;100.909;512.733;154.987 11.3392;6.46469;299.351;437.5;110.795;16.0812;79.4619;16.4151;3.4063;123.177;507.146;444.211;89.164;18.8755;0.998544;0.808077;75.6422;57.2867;554.87;15.4867;1.51678;73.3629;330.024;53.5946 63.97775;58.9909;772.521;940.187;426.677;262.985;192.339;37.0434;13.4683;668.095;5065.92;2183.16;231.33;122.765;10.914;13.1174;172.041;106.529;4240.48;41.3795;45.9052;159.385;1002.56;462.615 16 9 15 286954;246273;363140;360918;24614;24314;83619;25587;24424;300850;116686;297417;25315;24296;25612 UGT2B10_33303,UGT2B1_33224;TRIB3_10079;RASSF1_32475;PF4_32963;ORM1_9400;NQO1_33055;NFE2L2_9301;ID2_8861;GSTM2_8759;GSTA4_8757;GSR_8755;GFPT1_8705;EPHX1_8567;CYP1A1_8415;ASNS_8091 167.65885466666666 56.9823 293.0994712924477 95.60341406666666 16.4151 167.47533568522138 467.31935 106.529 1073.4629828135664 25.4966;16.8949;756.581;179.631;56.9823;24.1117;6.6423;2.99674;3.28268;105.355;74.6342;981.5;24.8784;100.909;154.987 11.3392;6.46469;437.5;110.795;16.0812;16.4151;3.4063;0.998544;0.808077;75.6422;57.2867;554.87;15.4867;73.3629;53.5946 63.97775;58.9909;940.187;426.677;262.985;37.0434;13.4683;10.914;13.1174;172.041;106.529;4240.48;41.3795;159.385;462.615 9 170698;338475;307126;59107;24539;29200;24484;24330;58919 SLCO1A2_9886;NREP_9364;MCM10_32579;LTBP1_33264;LPL_32544;INHBA_33300;IGFBP3_8881;EGR1_8533;CCND1_8224 359.05618333333337 213.608 347.1320547965158 210.32524222222222 123.177 188.65065030033043 1142.7328 668.095 1613.735624751483 440.994;112.624;213.608;998.777;769.435;130.168;44.9033;8.26335;512.733 299.351;79.4619;123.177;507.146;444.211;89.164;18.8755;1.51678;330.024 772.521;192.339;668.095;5065.92;2183.16;231.33;122.765;45.9052;1002.56 0 Exp 2,4(0.16);Exp 4,9(0.36);Hill,3(0.12);Linear,1(0.04);Poly 2,8(0.32) 2.0018222004079402 53.11356163024902 1.5232417583465576 5.289852619171143 0.9304897935005144 1.826043963432312 110.92959131085811 367.93611452247524 66.30939411470783 210.9388051352922 196.08280173060166 1245.1159857693983 UP 0.625 0.375 0.0 GO:0019219 6 regulation of nucleobase-containing compound metabolic process 550 589 32 28 15 22 13 13 39 576 1919 0.69545 0.42637 0.74043 2.21 24522;246273;360918;316351;83619;29200;24484;494344;25587;24330;289185;25695;58919 zfp354a;trib3;pf4;npas2;nfe2l2;inhba;igfbp3;ier2;id2;egr1;creg1;cebpd;ccnd1 ZFP354A_10203;TRIB3_10079;PF4_32963;NPAS2_9350;NFE2L2_9301;INHBA_33300;IGFBP3_8881;IER2_32643;ID2_8861;EGR1_8533;CREG1_8380;CEBPD_8283;CCND1_8224 129.49843615384614 44.9033 2.99674 186.85449775011358 129.0313747692654 189.0623555717829 82.08001800000001 18.8755 0.998544 126.26966181896174 79.22412530456322 126.8842108377761 260.1879692307692 122.765 6.6682 349.3622944207736 261.674504918692 355.48776041251085 3.26713;16.8949;179.631;134.458;6.6423;130.168;44.9033;543.54;2.99674;8.26335;94.3216;5.66035;512.733 1.71987;6.46469;110.795;56.7249;3.4063;89.164;18.8755;375.947;0.998544;1.51678;69.2457;2.15795;330.024 6.6682;58.9909;426.677;320.448;13.4683;231.33;122.765;978.946;10.914;45.9052;147.421;16.35;1002.56 5 8 5 246273;360918;83619;25587;289185 TRIB3_10079;PF4_32963;NFE2L2_9301;ID2_8861;CREG1_8380 60.097308 16.8949 76.55711346643967 38.1820468 6.46469 49.58716489906709 131.49424 58.9909 174.00644714191773 16.8949;179.631;6.6423;2.99674;94.3216 6.46469;110.795;3.4063;0.998544;69.2457 58.9909;426.677;13.4683;10.914;147.421 8 24522;316351;29200;24484;494344;24330;25695;58919 ZFP354A_10203;NPAS2_9350;INHBA_33300;IGFBP3_8881;IER2_32643;EGR1_8533;CEBPD_8283;CCND1_8224 172.87414124999998 87.53565 225.64101583149167 109.51625 37.8002 153.91818247337392 340.62155 177.0475 415.5836363353625 3.26713;134.458;130.168;44.9033;543.54;8.26335;5.66035;512.733 1.71987;56.7249;89.164;18.8755;375.947;1.51678;2.15795;330.024 6.6682;320.448;231.33;122.765;978.946;45.9052;16.35;1002.56 0 Exp 2,1(0.08);Exp 4,5(0.39);Hill,3(0.24);Linear,1(0.08);Poly 2,3(0.24) 2.1053209392497423 31.14893901348114 1.5423688888549805 6.495501518249512 1.585038731372316 1.8309566974639893 27.92317411764259 231.0736981900497 13.439047935494017 150.72098806450597 70.27246262724779 450.10347583429063 DOWN 0.38461538461538464 0.6153846153846154 0.0 GO:0065003 6 protein-containing complex assembly 203 233 5 4 2 4 2 2 50 231 2264 0.13144 0.95895 0.22827 0.86 360918;25333 pf4;mgp PF4_32963;MGP_33209 127.36574999999999 127.36574999999999 75.1005 73.91422539082042 85.44509039741581 44.14328161899082 62.3631 62.3631 13.9312 68.4930498314975 23.517075274079875 40.90563043404177 386.454 386.454 346.231 56.883912119333296 354.19213018794045 33.972385410205135 179.631;75.1005 110.795;13.9312 426.677;346.231 1 1 1 360918 PF4_32963 179.631 179.631 110.795 110.795 426.677 426.677 179.631 110.795 426.677 1 25333 MGP_33209 75.1005 75.1005 13.9312 13.9312 346.231 346.231 75.1005 13.9312 346.231 0 Hill,1(0.5);Poly 2,1(0.5) 1.9377241972969979 3.878714084625244 1.8597915172576904 2.0189225673675537 0.11252264463002062 1.939357042312622 24.92586 229.80563999999998 -32.56342399999998 157.289624 307.61692 465.29108 CONFLICT 0.5 0.5 0.0 GO:0032269 7 negative regulation of cellular protein metabolic process 274 292 16 15 6 6 3 3 49 289 2206 0.136 0.94838 0.2696 1.03 246273;299270;24484 trib3;serpina6;igfbp3 TRIB3_10079;SERPINA6_32325;IGFBP3_8881 25.881866666666667 16.8949 15.8474 16.48136852944359 37.35563581783801 15.340220191415492 11.031096666666665 7.7531 6.46469 6.8239283278792815 15.672174724235738 6.520044621675482 74.19736666666667 58.9909 40.8362 43.02917078823774 104.3094288055468 37.87114155160211 16.8949;15.8474;44.9033 6.46469;7.7531;18.8755 58.9909;40.8362;122.765 1 2 1 246273 TRIB3_10079 16.8949 16.8949 6.46469 6.46469 58.9909 58.9909 16.8949 6.46469 58.9909 2 299270;24484 SERPINA6_32325;IGFBP3_8881 30.37535 30.37535 20.5456239234782 13.3143 13.3143 7.864724463069256 81.8006 81.8006 57.932410054476414 15.8474;44.9033 7.7531;18.8755 40.8362;122.765 0 Exp 4,3(1) 1.8953055742114668 5.737090349197388 1.6548216342926025 2.2692105770111084 0.319005645644775 1.8130581378936768 7.231442454774815 44.53229087855852 3.3090948268843077 18.753098506449025 25.505276124979588 122.88945720835375 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0001889 6 liver development 91 101 7 7 6 6 5 5 47 96 2399 0.98447 0.052781 0.052781 4.95 25315;24296;58919;25612;24188 ephx1;cyp1a1;ccnd1;asns;aldh1a1 EPHX1_8567;CYP1A1_8415;CCND1_8224;ASNS_8091;ALDH1A1_8022 176.40285999999998 100.909 24.8784 193.62417642967003 198.13764261813913 200.25143284183895 107.68337999999999 65.9487 15.4867 126.27435813440907 127.88448954725564 128.2058955538851 359.9169 159.385 41.3795 392.5605509240581 380.4969165688289 407.4277187400693 24.8784;100.909;512.733;154.987;88.5069 15.4867;73.3629;330.024;53.5946;65.9487 41.3795;159.385;1002.56;462.615;133.645 4 1 4 25315;24296;25612;24188 EPHX1_8567;CYP1A1_8415;ASNS_8091;ALDH1A1_8022 92.320325 94.70795000000001 53.42855962793526 52.098225 59.77165 25.733667710786335 199.256125 146.515 182.73610489372146 24.8784;100.909;154.987;88.5069 15.4867;73.3629;53.5946;65.9487 41.3795;159.385;462.615;133.645 1 58919 CCND1_8224 512.733 512.733 330.024 330.024 1002.56 1002.56 512.733 330.024 1002.56 0 Exp 2,1(0.2);Exp 4,2(0.4);Poly 2,2(0.4) 2.249899441302901 11.53202748298645 1.555469274520874 2.79919695854187 0.5439753556111887 2.634152889251709 6.683786331011362 346.1219336689886 -3.000975052647334 218.36773505264733 15.82240575682306 704.0113942431769 UP 0.8 0.2 0.0 GO:0045935 7 positive regulation of nucleobase-containing compound metabolic process 358 387 20 19 10 14 9 9 43 378 2117 0.74233 0.39174 0.69519 2.33 360918;316351;83619;29200;24484;494344;25587;24330;25695 pf4;npas2;nfe2l2;inhba;igfbp3;ier2;id2;egr1;cebpd PF4_32963;NPAS2_9350;NFE2L2_9301;INHBA_33300;IGFBP3_8881;IER2_32643;ID2_8861;EGR1_8533;CEBPD_8283 117.36255999999997 44.9033 2.99674 173.54022761573546 100.72967453640779 156.787442931179 73.28733044444445 18.8755 0.998544 120.83881755089199 58.40839678373785 109.11850089519605 240.75594444444445 122.765 10.914 314.77463473767665 213.78495366747578 282.28388935734466 179.631;134.458;6.6423;130.168;44.9033;543.54;2.99674;8.26335;5.66035 110.795;56.7249;3.4063;89.164;18.8755;375.947;0.998544;1.51678;2.15795 426.677;320.448;13.4683;231.33;122.765;978.946;10.914;45.9052;16.35 3 6 3 360918;83619;25587 PF4_32963;NFE2L2_9301;ID2_8861 63.09001333333333 6.6423 100.94391366921799 38.399948 3.4063 62.70751141451009 150.3531 13.4683 239.3069250889535 179.631;6.6423;2.99674 110.795;3.4063;0.998544 426.677;13.4683;10.914 6 316351;29200;24484;494344;24330;25695 NPAS2_9350;INHBA_33300;IGFBP3_8881;IER2_32643;EGR1_8533;CEBPD_8283 144.49883333333332 87.53565 203.6151003467416 90.73102166666666 37.8002 143.85729880612112 285.9573666666667 177.0475 358.1485508351062 134.458;130.168;44.9033;543.54;8.26335;5.66035 56.7249;89.164;18.8755;375.947;1.51678;2.15795 320.448;231.33;122.765;978.946;45.9052;16.35 0 Exp 4,3(0.34);Hill,3(0.34);Linear,1(0.12);Poly 2,2(0.23) 1.9349912409354384 18.997800946235657 1.5423688888549805 5.289852619171143 1.2025343402950264 1.6548216342926025 3.982944624386164 230.7421753756138 -5.660697022138322 152.23535791102722 35.10318308249563 446.4087058063933 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0019369 6 arachidonic acid metabolic process 29 34 7 7 4 6 3 3 49 31 2464 0.99544 0.030772 0.030772 8.82 25315;499353;29277 ephx1;cyp2c24;cyp2c11 EPHX1_8567;CYP2C24_32875;CYP2C11_32593 296.2491333333333 129.934 24.8784 382.66938495606524 545.8625762092379 364.586420284525 174.66776666666667 45.3106 15.4867 250.32598811178863 339.061586000503 239.78159981961133 720.0908333333333 355.143 41.3795 917.3495656556355 1315.5496949450917 871.0669476818318 0.5 77.4062 24.8784;733.935;129.934 15.4867;463.206;45.3106 41.3795;1763.75;355.143 1 2 1 25315 EPHX1_8567 24.8784 24.8784 15.4867 15.4867 41.3795 41.3795 24.8784 15.4867 41.3795 2 499353;29277 CYP2C24_32875;CYP2C11_32593 431.93449999999996 431.93449999999996 427.0932029434558 254.25830000000002 254.25830000000002 295.4966711666647 1059.4465 1059.4465 996.0355617268393 733.935;129.934 463.206;45.3106 1763.75;355.143 0 Exp 4,2(0.67);Linear,1(0.34) 1.9418242913664279 5.970514893531799 1.628912329673767 2.6370131969451904 0.5614577115822221 1.7045893669128418 -136.78204060009188 729.2803072667584 -108.60275551147379 457.9382888448072 -317.987923264311 1758.1695899309775 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0048583 4 regulation of response to stimulus 781 832 34 32 19 22 14 14 38 818 1677 0.23126 0.85163 0.45552 1.68 308843;246273;360918;338475;316351;83619;59107;24539;29200;24484;24424;289388;24330;117517 tsku;trib3;pf4;nrep;npas2;nfe2l2;ltbp1;lpl;inhba;igfbp3;gstm2;g0s2;egr1;c7 TSKU_10094;TRIB3_10079;PF4_32963;NREP_9364;NPAS2_9350;NFE2L2_9301;LTBP1_33264;LPL_32544;INHBA_33300;IGFBP3_8881;GSTM2_8759;G0S2_32729;EGR1_8533;C7_8179 173.46425214285713 30.8991 3.28268 310.2068753893078 268.7611503968616 375.42983196272905 94.74592835714286 12.670095 0.808077 166.18974239111247 144.82448641756946 202.2682079787933 626.5480857142858 90.87795 13.1174 1395.9773763794128 994.9834396232648 1689.7851888315333 6.12626;16.8949;179.631;112.624;134.458;6.6423;998.777;769.435;130.168;44.9033;3.28268;3.45084;8.26335;13.8429 1.46625;6.46469;110.795;79.4619;56.7249;3.4063;507.146;444.211;89.164;18.8755;0.808077;1.07374;1.51678;5.32886 41.3339;58.9909;426.677;192.339;320.448;13.4683;5065.92;2183.16;231.33;122.765;13.1174;14.3222;45.9052;41.8963 5 9 5 246273;360918;83619;24424;289388 TRIB3_10079;PF4_32963;NFE2L2_9301;GSTM2_8759;G0S2_32729 41.980344 6.6423 77.1488688011631 24.509561400000003 3.4063 48.28855979269257 105.31516000000002 14.3222 180.71757017731562 16.8949;179.631;6.6423;3.28268;3.45084 6.46469;110.795;3.4063;0.808077;1.07374 58.9909;426.677;13.4683;13.1174;14.3222 9 308843;338475;316351;59107;24539;29200;24484;24330;117517 TSKU_10094;NREP_9364;NPAS2_9350;LTBP1_33264;LPL_32544;INHBA_33300;IGFBP3_8881;EGR1_8533;C7_8179 246.5108677777778 112.624 369.57709229116404 133.7661322222222 56.7249 197.27877900231795 916.1219333333332 192.339 1698.8987449878489 6.12626;112.624;134.458;998.777;769.435;130.168;44.9033;8.26335;13.8429 1.46625;79.4619;56.7249;507.146;444.211;89.164;18.8755;1.51678;5.32886 41.3339;192.339;320.448;5065.92;2183.16;231.33;122.765;45.9052;41.8963 0 Exp 2,2(0.15);Exp 4,4(0.29);Hill,5(0.36);Poly 2,3(0.22) 2.0169765517681357 29.912530303001404 1.5423688888549805 5.289852619171143 0.9535584239429151 1.8429177403450012 10.967953600871795 335.96055068484253 7.690417545815848 181.80143916846987 -104.70958297962147 1357.805754408193 DOWN 0.35714285714285715 0.6428571428571429 0.0 GO:0098754 2 detoxification 44 58 7 7 5 6 5 5 47 53 2442 0.99903 0.0058961 0.0058961 8.62 24314;83619;24424;116686;26760 nqo1;nfe2l2;gstm2;gsr;akr7a3 NQO1_33055;NFE2L2_9301;GSTM2_8759;GSR_8755;AKR7A3_8015 25.704196000000003 19.8501 3.28268 28.709893912118176 34.839905787204856 31.100918331240493 18.1426354 12.797 0.808077 22.811534832959307 25.300054927059854 24.89656795035255 40.5025 32.3544 13.1174 38.46637258801511 52.459186778681286 42.18591234242635 1.5 13.2462 24.1117;6.6423;3.28268;74.6342;19.8501 16.4151;3.4063;0.808077;57.2867;12.797 37.0434;13.4683;13.1174;106.529;32.3544 5 0 5 24314;83619;24424;116686;26760 NQO1_33055;NFE2L2_9301;GSTM2_8759;GSR_8755;AKR7A3_8015 25.704196000000003 19.8501 28.709893912118176 18.1426354 12.797 22.811534832959307 40.5025 32.3544 38.46637258801511 24.1117;6.6423;3.28268;74.6342;19.8501 16.4151;3.4063;0.808077;57.2867;12.797 37.0434;13.4683;13.1174;106.529;32.3544 0 0 Exp 4,3(0.6);Hill,1(0.2);Poly 2,1(0.2) 2.519417204365694 14.104378461837769 1.5423688888549805 4.773829460144043 1.5102063349092423 1.9608341455459595 0.5388644295929907 50.869527570407016 -1.8525564825797147 38.137827282579714 6.785237809782579 74.21976219021741 UP 1.0 0.0 0.0 GO:0044237 3 cellular metabolic process 1201 1328 79 75 38 61 31 31 21 1297 1198 0.89112 0.17113 0.3266 2.33 286954;246273;305291;266730;501907;24314;83619;307126;24539;29200;24484;24424;300850;116686;297417;246248;25598;25315;24330;499353;29277;24296;290277;58919;54232;25612;64392;24188;26760;24763;296925 ugt2b1;trib3;srd5a3;slc17a3;rgd1559459;nqo1;nfe2l2;mcm10;lpl;inhba;igfbp3;gstm2;gsta4;gsr;gfpt1;fmo5;fabp2;ephx1;egr1;cyp2c24;cyp2c11;cyp1a1;cryl1;ccnd1;car3;asns;aldh1l1;aldh1a1;akr7a3;acsm3;aass UGT2B10_33303,UGT2B1_33224;TRIB3_10079;SRD5A3_9939;SLC17A3_9840;RGD1559459_9690;NQO1_33055;NFE2L2_9301;MCM10_32579;LPL_32544;INHBA_33300;IGFBP3_8881;GSTM2_8759;GSTA4_8757;GSR_8755;GFPT1_8705;FMO5_33281;FABP2_32859;EPHX1_8567;EGR1_8533;CYP2C24_32875;CYP2C11_32593;CYP1A1_8415;CRYL1_8388;CCND1_8224;CAR3_8196;ASNS_8091;ALDH1L1_32662;ALDH1A1_8022;AKR7A3_8015;ACSM3_7976;AASS_7936 175.77056548387097 76.0301 3.28268 248.72727948574126 194.76133784481925 250.18008607903772 105.16673764516129 46.6655 0.808077 150.70675769089422 119.51679933953515 153.82980576511906 495.2258048387096 133.645 13.1174 866.5654508734291 489.6478602720356 703.4979532966895 25.4966;16.8949;169.209;58.7587;42.78;24.1117;6.6423;213.608;769.435;130.168;44.9033;3.28268;105.355;74.6342;981.5;57.4978;146.645;24.8784;8.26335;733.935;129.934;100.909;76.0301;512.733;55.21;154.987;184.03;88.5069;19.8501;460.125;28.5735 11.3392;6.46469;105.547;46.6655;20.6065;16.4151;3.4063;123.177;444.211;89.164;18.8755;0.808077;75.6422;57.2867;554.87;31.5489;95.8536;15.4867;1.51678;463.206;45.3106;73.3629;23.2788;330.024;24.6611;53.5946;111.154;65.9487;12.797;331.8;6.14642 63.97775;58.9909;459.211;78.8953;93.6128;37.0434;13.4683;668.095;2183.16;231.33;122.765;13.1174;172.041;106.529;4240.48;109.026;319.535;41.3795;45.9052;1763.75;355.143;159.385;250.463;1002.56;106.714;462.615;1150.07;133.645;32.3544;748.659;128.079 21 11 20 286954;246273;305291;266730;501907;24314;83619;24424;300850;116686;297417;246248;25598;25315;24296;290277;25612;64392;24188;26760 UGT2B10_33303,UGT2B1_33224;TRIB3_10079;SRD5A3_9939;SLC17A3_9840;RGD1559459_9690;NQO1_33055;NFE2L2_9301;GSTM2_8759;GSTA4_8757;GSR_8755;GFPT1_8705;FMO5_33281;FABP2_32859;EPHX1_8567;CYP1A1_8415;CRYL1_8388;ASNS_8091;ALDH1L1_32662;ALDH1A1_8022;AKR7A3_8015 118.09996900000002 66.69645 210.7698568715067 69.10382335 39.1072 119.57373690911703 399.79198749999995 107.7775 940.8989010000411 25.4966;16.8949;169.209;58.7587;42.78;24.1117;6.6423;3.28268;105.355;74.6342;981.5;57.4978;146.645;24.8784;100.909;76.0301;154.987;184.03;88.5069;19.8501 11.3392;6.46469;105.547;46.6655;20.6065;16.4151;3.4063;0.808077;75.6422;57.2867;554.87;31.5489;95.8536;15.4867;73.3629;23.2788;53.5946;111.154;65.9487;12.797 63.97775;58.9909;459.211;78.8953;93.6128;37.0434;13.4683;13.1174;172.041;106.529;4240.48;109.026;319.535;41.3795;159.385;250.463;462.615;1150.07;133.645;32.3544 11 307126;24539;29200;24484;24330;499353;29277;58919;54232;24763;296925 MCM10_32579;LPL_32544;INHBA_33300;IGFBP3_8881;EGR1_8533;CYP2C24_32875;CYP2C11_32593;CCND1_8224;CAR3_8196;ACSM3_7976;AASS_7936 280.62619545454544 130.168 287.13122080089835 170.7356727272727 89.164 183.4157295125548 668.7418363636364 355.143 720.7085477688566 213.608;769.435;130.168;44.9033;8.26335;733.935;129.934;512.733;55.21;460.125;28.5735 123.177;444.211;89.164;18.8755;1.51678;463.206;45.3106;330.024;24.6611;331.8;6.14642 668.095;2183.16;231.33;122.765;45.9052;1763.75;355.143;1002.56;106.714;748.659;128.079 0 Exp 2,2(0.07);Exp 4,11(0.35);Exp 5,2(0.07);Hill,4(0.13);Linear,3(0.1);Poly 2,10(0.32) 2.044052444427212 69.5112476348877 1.5232417583465576 5.289852619171143 0.9225122492529184 1.778340995311737 88.21199870137514 263.32913226636686 52.11398148936519 158.21949380095742 190.17189575973197 800.2797139176873 UP 0.6451612903225806 0.3548387096774194 0.0 GO:0007576 8 nucleolar fragmentation 1 1 1 1 1 1 1 1 51 0 2495 1.0 0.020416 0.020416 100.0 24522 zfp354a ZFP354A_10203 3.26713 3.26713 3.26713 3.26713 1.71987 1.71987 1.71987 1.7198699999999998 6.6682 6.6682 6.6682 6.6682 0.0 3.26713 0.0 3.26713 3.26713 1.71987 6.6682 0 1 0 1 24522 ZFP354A_10203 3.26713 3.26713 1.71987 1.71987 6.6682 6.6682 3.26713 1.71987 6.6682 0 Exp 4,1(1) 6.495501518249512 6.495501518249512 6.495501518249512 6.495501518249512 0.0 6.495501518249512 3.26713 3.26713 1.71987 1.71987 6.6682 6.6682 DOWN 0.0 1.0 0.0 GO:0006529 7 asparagine biosynthetic process 1 1 1 1 1 1 1 1 51 0 2495 1.0 0.020416 0.020416 100.0 25612 asns ASNS_8091 154.987 154.987 154.987 154.987 53.5946 53.5946 53.5946 53.5946 462.615 462.615 462.615 462.615 0.0 154.987 0.0 154.987 154.987 53.5946 462.615 1 0 1 25612 ASNS_8091 154.987 154.987 53.5946 53.5946 462.615 462.615 154.987 53.5946 462.615 0 0 Exp 4,1(1) 2.634152889251709 2.634152889251709 2.634152889251709 2.634152889251709 0.0 2.634152889251709 154.987 154.987 53.5946 53.5946 462.615 462.615 UP 1.0 0.0 0.0 GO:0070981 7 L-asparagine biosynthetic process 1 1 1 1 1 1 1 1 51 0 2495 1.0 0.020416 0.020416 100.0 25612 asns ASNS_8091 154.987 154.987 154.987 154.987 53.5946 53.5946 53.5946 53.5946 462.615 462.615 462.615 462.615 0.0 154.987 0.0 154.987 154.987 53.5946 462.615 1 0 1 25612 ASNS_8091 154.987 154.987 53.5946 53.5946 462.615 462.615 154.987 53.5946 462.615 0 0 Exp 4,1(1) 2.634152889251709 2.634152889251709 2.634152889251709 2.634152889251709 0.0 2.634152889251709 154.987 154.987 53.5946 53.5946 462.615 462.615 UP 1.0 0.0 0.0 GO:0070982 7 L-asparagine metabolic process 1 1 1 1 1 1 1 1 51 0 2495 1.0 0.020416 0.020416 100.0 25612 asns ASNS_8091 154.987 154.987 154.987 154.987 53.5946 53.5946 53.5946 53.5946 462.615 462.615 462.615 462.615 0.0 154.987 0.0 154.987 154.987 53.5946 462.615 1 0 1 25612 ASNS_8091 154.987 154.987 53.5946 53.5946 462.615 462.615 154.987 53.5946 462.615 0 0 Exp 4,1(1) 2.634152889251709 2.634152889251709 2.634152889251709 2.634152889251709 0.0 2.634152889251709 154.987 154.987 53.5946 53.5946 462.615 462.615 UP 1.0 0.0 0.0 GO:0071900 8 regulation of protein serine/threonine kinase activity 142 154 4 4 2 2 2 2 50 152 2343 0.38163 0.83323 0.76778 1.3 246273;58919 trib3;ccnd1 TRIB3_10079;CCND1_8224 264.81395 264.81395 16.8949 350.6104828806535 381.6059363514119 309.2684506282336 168.244345 168.244345 6.46469 228.79098221704027 244.45699287315108 201.8132259099096 530.77545 530.77545 58.9909 667.2041091280876 753.0280551322278 588.5311225935978 16.8949;512.733 6.46469;330.024 58.9909;1002.56 1 1 1 246273 TRIB3_10079 16.8949 16.8949 6.46469 6.46469 58.9909 58.9909 16.8949 6.46469 58.9909 1 58919 CCND1_8224 512.733 512.733 330.024 330.024 1002.56 1002.56 512.733 330.024 1002.56 0 Exp 2,1(0.5);Exp 4,1(0.5) 1.8787462122273362 3.8246798515319824 1.555469274520874 2.2692105770111084 0.5046913150037636 1.9123399257659912 -221.1073879999999 750.7352879999999 -148.84377879999997 485.3324687999999 -393.9222679999999 1455.473168 CONFLICT 0.5 0.5 0.0 GO:0052695 9 cellular glucuronidation 3 10 2 2 2 2 2 2 50 8 2487 0.99913 0.01657 0.01657 20.0 286954;501907 ugt2b1;rgd1559459 UGT2B10_33303,UGT2B1_33224;RGD1559459_9690 34.1383 34.1383 25.4966 12.221209341959561 37.355692976045475 11.342606519463972 15.972850000000001 15.972850000000001 11.3392 6.552970673290086 17.69800511571255 6.081866843203782 78.795275 78.795275 63.97775 20.95514481580229 84.31199056029233 19.448645019766857 0.0 25.4966 0.0 25.4966 25.4966;42.78 11.3392;20.6065 63.97775;93.6128 3 0 2 286954;501907 UGT2B10_33303,UGT2B1_33224;RGD1559459_9690 34.1383 34.1383 12.221209341959561 15.972850000000001 15.972850000000001 6.552970673290086 78.795275 78.795275 20.95514481580229 25.4966;42.78 11.3392;20.6065 63.97775;93.6128 0 0 Exp 4,3(1) 1.8192961186682537 5.483303427696228 1.6986740827560425 2.0820155143737793 0.22019378301979642 1.7026138305664062 17.200568000000004 51.076032 6.8908960000000015 25.054804 49.752926000000016 107.83762399999999 UP 1.0 0.0 0.0 GO:0071372 7 cellular response to follicle-stimulating hormone stimulus 17 19 3 3 3 3 3 3 49 16 2479 0.99952 0.006176 0.006176 15.79 29200;25587;24330 inhba;id2;egr1 INHBA_33300;ID2_8861;EGR1_8533 47.142696666666666 8.26335 2.99674 71.95022613179916 43.02788141090105 68.88855419835491 30.55977466666667 1.51678 0.998544 50.75340936654409 27.167553936041834 48.98096691253825 96.04973333333334 45.9052 10.914 118.455303517459 93.37139283990345 110.1977949383943 0.0 2.99674 0.5 5.630045000000001 130.168;2.99674;8.26335 89.164;0.998544;1.51678 231.33;10.914;45.9052 1 2 1 25587 ID2_8861 2.99674 2.99674 0.998544 0.998544 10.914 10.914 2.99674 0.998544 10.914 2 29200;24330 INHBA_33300;EGR1_8533 69.215675 69.215675 86.19960467317266 45.34039 45.34039 61.975943614149195 138.6176 138.6176 131.11513348015936 130.168;8.26335 89.164;1.51678 231.33;45.9052 0 Hill,2(0.67);Poly 2,1(0.34) 2.5769681946838885 8.903332114219666 1.6357452869415283 5.289852619171143 2.0182329394202014 1.9777342081069946 -34.27664888721277 128.56204222054612 -26.873114671061728 87.99266400439505 -37.99506135724448 230.09452802391115 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0043604 6 amide biosynthetic process 50 60 3 2 2 2 2 2 50 58 2437 0.87792 0.34809 0.34809 3.33 25612;64392 asns;aldh1l1 ASNS_8091;ALDH1L1_32662 169.5085 169.5085 154.987 20.536502246000886 169.14526364798246 20.53007655137086 82.3743 82.3743 53.5946 40.70064206102896 81.65441340149717 40.68790718076554 806.3425 806.3425 462.615 486.1040922605982 797.7446056235165 485.9519944779337 154.987;184.03 53.5946;111.154 462.615;1150.07 2 0 2 25612;64392 ASNS_8091;ALDH1L1_32662 169.5085 169.5085 20.536502246000886 82.3743 82.3743 40.70064206102896 806.3425 806.3425 486.1040922605982 154.987;184.03 53.5946;111.154 462.615;1150.07 0 0 Exp 4,1(0.5);Poly 2,1(0.5) 2.15399289284542 4.39551055431366 1.7613576650619507 2.634152889251709 0.6171594216118111 2.19775527715683 141.04636 197.97064 25.966088000000006 138.782512 132.63660000000016 1480.0483999999997 UP 1.0 0.0 0.0 GO:0097327 5 response to antineoplastic agent 75 80 7 7 4 5 3 3 49 77 2418 0.92167 0.22262 0.22262 3.75 24424;24330;25612 gstm2;egr1;asns GSTM2_8759;EGR1_8533;ASNS_8091 55.51101 8.26335 3.28268 86.18472143177293 54.01654455834365 84.04685209007381 18.639819 1.51678 0.808077 30.27380222327587 17.88182742669067 29.720544335691102 173.8792 45.9052 13.1174 250.5893685064073 173.6399648475301 240.8062520021657 3.28268;8.26335;154.987 0.808077;1.51678;53.5946 13.1174;45.9052;462.615 2 1 2 24424;25612 GSTM2_8759;ASNS_8091 79.13484 79.13484 107.271153407294 27.2013385 27.2013385 37.32570836855966 237.8662 237.8662 317.84280108707827 3.28268;154.987 0.808077;53.5946 13.1174;462.615 1 24330 EGR1_8533 8.26335 8.26335 1.51678 1.51678 45.9052 45.9052 8.26335 1.51678 45.9052 0 Exp 4,1(0.34);Hill,2(0.67) 2.8752796301286763 9.629913926124573 1.7059084177017212 5.289852619171143 1.8600642862413634 2.634152889251709 -42.01618335258734 153.03820335258732 -15.618213211483557 52.89785121148356 -109.6893651519359 457.44776515193587 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0015722 7 canalicular bile acid transport 4 4 1 1 1 1 1 1 51 3 2492 0.99761 0.079243 0.079243 25.0 140668 abcc3 ABCC3_7941 86.4919 86.4919 86.4919 86.4919 40.4498 40.4498 40.4498 40.4498 108.02 108.02 108.02 108.02 0.0 86.4919 0.0 86.4919 86.4919 40.4498 108.02 1 0 1 140668 ABCC3_7941 86.4919 86.4919 40.4498 40.4498 108.02 108.02 86.4919 40.4498 108.02 0 0 Exp 5,1(1) 3.368933916091919 3.368933916091919 3.368933916091919 3.368933916091919 0.0 3.368933916091919 86.4919 86.4919 40.4498 40.4498 108.02 108.02 UP 1.0 0.0 0.0 GO:0042592 4 homeostatic process 357 379 25 23 11 17 8 8 44 371 2124 0.63312 0.5194 0.84519 2.11 24314;83619;24539;24424;116686;24330;117517;114628 nqo1;nfe2l2;lpl;gstm2;gsr;egr1;c7;abcg5 NQO1_33055;NFE2L2_9301;LPL_32544;GSTM2_8759;GSR_8755;EGR1_8533;C7_8179;ABCG5_7947 157.64751625 18.9773 3.28268 275.1551884373831 269.1786724966349 325.23586764654834 100.327477125 10.871979999999999 0.808077 167.02243071916024 170.5526996267602 192.7641211572224 371.21344999999997 43.90075 13.1174 752.152543951569 645.7531268093808 925.8751590214634 24.1117;6.6423;769.435;3.28268;74.6342;8.26335;13.8429;360.968 16.4151;3.4063;444.211;0.808077;57.2867;1.51678;5.32886;273.647 37.0434;13.4683;2183.16;13.1174;106.529;45.9052;41.8963;528.588 4 4 4 24314;83619;24424;116686 NQO1_33055;NFE2L2_9301;GSTM2_8759;GSR_8755 27.167720000000003 15.376999999999999 32.93525964580008 19.47904425 9.910699999999999 26.11350042573188 42.539525 25.25585 44.104640206776054 24.1117;6.6423;3.28268;74.6342 16.4151;3.4063;0.808077;57.2867 37.0434;13.4683;13.1174;106.529 4 24539;24330;117517;114628 LPL_32544;EGR1_8533;C7_8179;ABCG5_7947 288.1273125 187.40545 360.79478573871774 181.17591 139.48793 216.7471253505304 699.887375 287.2466 1014.9032952203158 769.435;8.26335;13.8429;360.968 444.211;1.51678;5.32886;273.647 2183.16;45.9052;41.8963;528.588 0 Exp 2,1(0.13);Exp 4,2(0.25);Hill,3(0.38);Linear,1(0.13);Poly 2,1(0.13) 2.417446295337513 21.576382517814636 1.5423688888549805 5.289852619171143 1.4764680726461767 2.056352198123932 -33.02530138028118 348.32033388028117 -15.41316237934295 216.0681166293429 -150.00167102856977 892.4285710285699 CONFLICT 0.5 0.5 0.0 GO:1901698 4 response to nitrogen compound 416 438 32 29 17 21 13 13 39 425 2070 0.94911 0.096966 0.13767 2.97 24522;286954;246273;24614;24314;83619;24484;24424;297417;24330;58919;25612;140668 zfp354a;ugt2b1;trib3;orm1;nqo1;nfe2l2;igfbp3;gstm2;gfpt1;egr1;ccnd1;asns;abcc3 ZFP354A_10203;UGT2B10_33303,UGT2B1_33224;TRIB3_10079;ORM1_9400;NQO1_33055;NFE2L2_9301;IGFBP3_8881;GSTM2_8759;GFPT1_8705;EGR1_8533;CCND1_8224;ASNS_8091;ABCC3_7941 148.11970461538462 25.4966 3.26713 285.6922031096356 105.60209265954542 191.49524767749216 81.1973166923077 16.0812 0.808077 167.49833306843374 57.51451181967994 119.3998767394366 495.2766269230769 63.97775 6.6682 1158.996506343974 273.13550964841096 603.3284687462659 3.26713;25.4966;16.8949;56.9823;24.1117;6.6423;44.9033;3.28268;981.5;8.26335;512.733;154.987;86.4919 1.71987;11.3392;6.46469;16.0812;16.4151;3.4063;18.8755;0.808077;554.87;1.51678;330.024;53.5946;40.4498 6.6682;63.97775;58.9909;262.985;37.0434;13.4683;122.765;13.1174;4240.48;45.9052;1002.56;462.615;108.02 10 4 9 286954;246273;24614;24314;83619;24424;297417;25612;140668 UGT2B10_33303,UGT2B1_33224;TRIB3_10079;ORM1_9400;NQO1_33055;NFE2L2_9301;GSTM2_8759;GFPT1_8705;ASNS_8091;ABCC3_7941 150.70993111111113 25.4966 315.2858793817108 78.15877411111111 16.0812 179.62489550353564 584.5219722222222 63.97775 1378.8953018949658 25.4966;16.8949;56.9823;24.1117;6.6423;3.28268;981.5;154.987;86.4919 11.3392;6.46469;16.0812;16.4151;3.4063;0.808077;554.87;53.5946;40.4498 63.97775;58.9909;262.985;37.0434;13.4683;13.1174;4240.48;462.615;108.02 4 24522;24484;24330;58919 ZFP354A_10203;IGFBP3_8881;EGR1_8533;CCND1_8224 142.29169499999998 26.583325000000002 247.65748314130497 88.0340375 10.297685 161.53164459472504 294.4746 84.3351 474.51322107420077 3.26713;44.9033;8.26335;512.733 1.71987;18.8755;1.51678;330.024 6.6682;122.765;45.9052;1002.56 0 Exp 2,1(0.08);Exp 4,9(0.65);Exp 5,1(0.08);Hill,2(0.15);Linear,1(0.08) 2.349488744137093 37.79926800727844 1.5232417583465576 6.495501518249512 1.650363880769688 1.7042611241340637 -7.184346087049647 303.42375531781886 -9.855814363742098 172.2504477483575 -134.76105078041337 1125.3143046265673 UP 0.6923076923076923 0.3076923076923077 0.0 GO:0015721 7 bile acid and bile salt transport 18 18 2 2 2 2 2 2 50 16 2479 0.99472 0.050784 0.050784 11.11 170698;140668 slco1a2;abcc3 SLCO1A2_9886;ABCC3_7941 263.74295 263.74295 86.4919 250.67083885487162 210.58036347243282 239.1304000741078 169.9004 169.9004 40.4498 183.07079417733456 131.07451590201867 174.64254100516357 440.27049999999997 440.27049999999997 108.02 469.87316320524195 340.61920904811296 448.2410399815536 0.0 86.4919 0.5 263.74295 440.994;86.4919 299.351;40.4498 772.521;108.02 1 1 1 140668 ABCC3_7941 86.4919 86.4919 40.4498 40.4498 108.02 108.02 86.4919 40.4498 108.02 1 170698 SLCO1A2_9886 440.994 440.994 299.351 299.351 772.521 772.521 440.994 299.351 772.521 0 Exp 2,1(0.5);Exp 5,1(0.5) 2.3738860118970324 5.041669249534607 1.672735333442688 3.368933916091919 1.1993935200302819 2.5208346247673035 -83.669108 611.155008 -83.82277600000003 423.623576 -210.94047999999998 1091.48148 CONFLICT 0.5 0.5 0.0 GO:0009635 4 response to herbicide 15 16 3 3 3 2 2 2 50 14 2481 0.99627 0.040873 0.040873 12.5 300850;24296 gsta4;cyp1a1 GSTA4_8757;CYP1A1_8415 103.132 103.132 100.909 3.1437967491554293 101.79179148109158 2.508214554557264 74.50255 74.50255 73.3629 1.611708486358555 73.81547458903555 1.2858689685563605 165.713 165.713 159.385 8.949143422696846 161.89795748643616 7.139892803074871 0.0 100.909 0.5 103.132 105.355;100.909 75.6422;73.3629 172.041;159.385 2 0 2 300850;24296 GSTA4_8757;CYP1A1_8415 103.132 103.132 3.1437967491554293 74.50255 74.50255 1.611708486358555 165.713 165.713 8.949143422696846 105.355;100.909 75.6422;73.3629 172.041;159.385 0 0 Poly 2,2(1) 1.98688024460626 3.977175712585449 1.9061951637268066 2.0709805488586426 0.11652086326715808 1.9885878562927246 98.77492000000001 107.48908 72.268836 76.736264 153.31011999999998 178.11588 UP 1.0 0.0 0.0 GO:0044248 4 cellular catabolic process 306 344 28 28 14 21 12 12 40 332 2163 0.98235 0.039995 0.06097 3.49 286954;305291;83619;24539;24424;25315;499353;29277;24296;64392;26760;296925 ugt2b1;srd5a3;nfe2l2;lpl;gstm2;ephx1;cyp2c24;cyp2c11;cyp1a1;aldh1l1;akr7a3;aass UGT2B10_33303,UGT2B1_33224;SRD5A3_9939;NFE2L2_9301;LPL_32544;GSTM2_8759;EPHX1_8567;CYP2C24_32875;CYP2C11_32593;CYP1A1_8415;ALDH1L1_32662;AKR7A3_8015;AASS_7936 183.01463166666667 64.74125000000001 3.28268 273.1727915917995 266.6507163353497 324.14128834478373 107.73126641666666 30.39865 0.808077 166.2756914326266 160.65401205376963 196.0182845979573 530.2579458333333 143.732 13.1174 751.4589185532661 718.4805488469814 872.1405370057107 25.4966;169.209;6.6423;769.435;3.28268;24.8784;733.935;129.934;100.909;184.03;19.8501;28.5735 11.3392;105.547;3.4063;444.211;0.808077;15.4867;463.206;45.3106;73.3629;111.154;12.797;6.14642 63.97775;459.211;13.4683;2183.16;13.1174;41.3795;1763.75;355.143;159.385;1150.07;32.3544;128.079 9 4 8 286954;305291;83619;24424;25315;24296;64392;26760 UGT2B10_33303,UGT2B1_33224;SRD5A3_9939;NFE2L2_9301;GSTM2_8759;EPHX1_8567;CYP1A1_8415;ALDH1L1_32662;AKR7A3_8015 66.78726 25.1875 74.36875503764199 41.737647124999995 14.141850000000002 47.03445687065079 241.62041875 52.678625 396.25056928177577 25.4966;169.209;6.6423;3.28268;24.8784;100.909;184.03;19.8501 11.3392;105.547;3.4063;0.808077;15.4867;73.3629;111.154;12.797 63.97775;459.211;13.4683;13.1174;41.3795;159.385;1150.07;32.3544 4 24539;499353;29277;296925 LPL_32544;CYP2C24_32875;CYP2C11_32593;AASS_7936 415.46937499999996 431.93449999999996 390.69633837405723 239.718505 244.76080000000002 247.7325125684531 1107.533 1059.4465 1018.661711010088 769.435;733.935;129.934;28.5735 444.211;463.206;45.3106;6.14642 2183.16;1763.75;355.143;128.079 0 Exp 2,1(0.08);Exp 4,6(0.47);Hill,2(0.16);Linear,1(0.08);Poly 2,3(0.24) 1.8618051196453909 25.24891459941864 1.5321133136749268 4.1214375495910645 0.7123870592933398 1.7026138305664062 28.45257460107578 337.5766887322576 13.651937512514905 201.81059532081844 105.08003709989333 955.4358545667731 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0120161 4 regulation of cold-induced thermogenesis 48 55 6 6 3 3 2 2 50 53 2442 0.89966 0.3102 0.3102 3.64 289388;24188 g0s2;aldh1a1 G0S2_32729;ALDH1A1_8022 45.97887 45.97887 3.45084 60.143716807009866 76.33627678048781 42.120332127011835 33.51122 33.51122 1.07374 45.87352414520603 56.66577889430894 32.12651587584246 73.98360000000001 73.98360000000001 14.3222 84.37396103016617 116.57116845528455 59.089451901781125 3.45084;88.5069 1.07374;65.9487 14.3222;133.645 2 0 2 289388;24188 G0S2_32729;ALDH1A1_8022 45.97887 45.97887 60.143716807009866 33.51122 33.51122 45.87352414520603 73.98360000000001 73.98360000000001 84.37396103016617 3.45084;88.5069 1.07374;65.9487 14.3222;133.645 0 0 Exp 4,1(0.5);Poly 2,1(0.5) 2.4132808580327425 4.8797667026519775 2.0805697441101074 2.79919695854187 0.5081461764698986 2.4398833513259888 -37.3760688 129.33380879999999 -30.06624079999999 97.08868079999999 -42.952743999999996 190.91994400000002 UP 1.0 0.0 0.0 GO:0002439 5 chronic inflammatory response to antigenic stimulus 2 3 1 1 1 1 1 1 51 2 2493 0.99879 0.06003 0.06003 33.33 24614 orm1 ORM1_9400 56.9823 56.9823 56.9823 56.9823 16.0812 16.0812 16.0812 16.0812 262.985 262.985 262.985 262.985 0.0 56.9823 0.0 56.9823 56.9823 16.0812 262.985 1 0 1 24614 ORM1_9400 56.9823 56.9823 16.0812 16.0812 262.985 262.985 56.9823 16.0812 262.985 0 0 Exp 4,1(1) 1.5846891403198242 1.5846891403198242 1.5846891403198242 1.5846891403198242 0.0 1.5846891403198242 56.9823 56.9823 16.0812 16.0812 262.985 262.985 UP 1.0 0.0 0.0 GO:0031401 8 positive regulation of protein modification process 319 340 14 11 7 8 6 6 46 334 2161 0.4469 0.71244 0.83824 1.76 246273;363140;29200;24484;24330;58919 trib3;rassf1;inhba;igfbp3;egr1;ccnd1 TRIB3_10079;RASSF1_32475;INHBA_33300;IGFBP3_8881;EGR1_8533;CCND1_8224 244.92392499999997 87.53565 8.26335 314.54643530000106 322.821218840923 347.3358613184073 147.257495 54.01975 1.51678 188.97834151487538 191.42577533192127 207.15505643513256 400.28968333333336 177.0475 45.9052 447.6291306126643 498.5382622874979 468.6881431591606 16.8949;756.581;130.168;44.9033;8.26335;512.733 6.46469;437.5;89.164;18.8755;1.51678;330.024 58.9909;940.187;231.33;122.765;45.9052;1002.56 2 4 2 246273;363140 TRIB3_10079;RASSF1_32475 386.73795 386.73795 523.0370572594306 221.982345 221.982345 304.7879906318457 499.58895 499.58895 623.099737865139 16.8949;756.581 6.46469;437.5 58.9909;940.187 4 29200;24484;24330;58919 INHBA_33300;IGFBP3_8881;EGR1_8533;CCND1_8224 174.0169125 87.53565 231.51377458874293 109.89507 54.01975 151.56620000580472 350.64005 177.0475 441.21985315563103 130.168;44.9033;8.26335;512.733 89.164;18.8755;1.51678;330.024 231.33;122.765;45.9052;1002.56 0 Exp 2,1(0.17);Exp 4,2(0.34);Hill,1(0.17);Poly 2,2(0.34) 2.1919801231341993 14.599788427352905 1.555469274520874 5.289852619171143 1.4322333794475917 1.924755334854126 -6.7656421861459535 496.61349218614595 -3.9566713219621192 298.47166132196213 42.11178175782027 758.4675849088463 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0051051 5 negative regulation of transport 140 146 11 10 5 6 3 3 49 143 2352 0.65193 0.58124 1.0 2.05 24484;24424;114628 igfbp3;gstm2;abcg5 IGFBP3_8881;GSTM2_8759;ABCG5_7947 136.38466000000003 44.9033 3.28268 195.60502666461005 178.36333482092755 194.54885901057912 97.776859 18.8755 0.808077 152.57567897599256 127.35101876442758 155.66839711725842 221.49013333333332 122.765 13.1174 271.5464487520567 290.86985774330196 254.6639096033583 44.9033;3.28268;360.968 18.8755;0.808077;273.647 122.765;13.1174;528.588 1 2 1 24424 GSTM2_8759 3.28268 3.28268 0.808077 0.808077 13.1174 13.1174 3.28268 0.808077 13.1174 2 24484;114628 IGFBP3_8881;ABCG5_7947 202.93565 202.93565 223.49149266369182 146.26125 146.26125 180.15065530306848 325.6765 325.6765 286.96019526146824 44.9033;360.968 18.8755;273.647 122.765;528.588 0 Exp 4,1(0.34);Hill,1(0.34);Linear,1(0.34) 1.8246279698757382 5.512600302696228 1.6548216342926025 2.1518702507019043 0.27341944060556933 1.7059084177017212 -84.96326500732684 357.73258500732686 -74.87877528401529 270.4324932840153 -85.79360062426088 528.7738672909276 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0019218 7 regulation of steroid metabolic process 46 49 6 6 2 6 2 2 50 47 2448 0.92336 0.26429 0.26429 4.08 246248;24330 fmo5;egr1 FMO5_33281;EGR1_8533 32.880575 32.880575 8.26335 34.81401346299001 26.587149300611966 33.657110977233536 16.53284 16.53284 1.51678 21.235915705408136 12.693964663419509 20.530226207901073 77.4656 77.4656 45.9052 44.633145713919845 69.39714255026851 43.14994420719154 57.4978;8.26335 31.5489;1.51678 109.026;45.9052 1 1 1 246248 FMO5_33281 57.4978 57.4978 31.5489 31.5489 109.026 109.026 57.4978 31.5489 109.026 1 24330 EGR1_8533 8.26335 8.26335 1.51678 1.51678 45.9052 45.9052 8.26335 1.51678 45.9052 0 Exp 5,1(0.5);Hill,1(0.5) 2.9821473179081748 6.9710341691970825 1.68118155002594 5.289852619171143 2.5517157840642812 3.4855170845985413 -15.369185999999992 81.130336 -12.898637599999997 45.9643176 15.607216000000008 139.323984 CONFLICT 0.5 0.5 0.0 GO:1901576 4 organic substance biosynthetic process 397 444 41 37 20 30 14 14 38 430 2065 0.97249 0.056158 0.093321 3.15 305291;24539;29200;24424;297417;25315;24330;29277;24296;25612;64392;24188;24763;296925 srd5a3;lpl;inhba;gstm2;gfpt1;ephx1;egr1;cyp2c11;cyp1a1;asns;aldh1l1;aldh1a1;acsm3;aass SRD5A3_9939;LPL_32544;INHBA_33300;GSTM2_8759;GFPT1_8705;EPHX1_8567;EGR1_8533;CYP2C11_32593;CYP1A1_8415;ASNS_8091;ALDH1L1_32662;ALDH1A1_8022;ACSM3_7976;AASS_7936 230.98584499999998 130.051 3.28268 298.7154321389568 232.26179457633407 278.61337386318365 135.63719835714284 69.6558 0.808077 176.31135546633317 140.32875354280225 165.36343125094237 739.4413642857143 293.2365 13.1174 1165.0146249766397 636.0586454890189 881.8707428715425 169.209;769.435;130.168;3.28268;981.5;24.8784;8.26335;129.934;100.909;154.987;184.03;88.5069;460.125;28.5735 105.547;444.211;89.164;0.808077;554.87;15.4867;1.51678;45.3106;73.3629;53.5946;111.154;65.9487;331.8;6.14642 459.211;2183.16;231.33;13.1174;4240.48;41.3795;45.9052;355.143;159.385;462.615;1150.07;133.645;748.659;128.079 8 6 8 305291;24424;297417;25315;24296;25612;64392;24188 SRD5A3_9939;GSTM2_8759;GFPT1_8705;EPHX1_8567;CYP1A1_8415;ASNS_8091;ALDH1L1_32662;ALDH1A1_8022 213.4128725 127.94800000000001 317.1631671020775 122.596497125 69.6558 178.8778941501025 832.4878624999999 309.298 1425.7869796722518 169.209;3.28268;981.5;24.8784;100.909;154.987;184.03;88.5069 105.547;0.808077;554.87;15.4867;73.3629;53.5946;111.154;65.9487 459.211;13.1174;4240.48;41.3795;159.385;462.615;1150.07;133.645 6 24539;29200;24330;29277;24763;296925 LPL_32544;INHBA_33300;EGR1_8533;CYP2C11_32593;ACSM3_7976;AASS_7936 254.416475 130.051 300.0300180904966 153.0248 67.2373 188.12680005757008 615.3793666666667 293.2365 806.5579869226556 769.435;130.168;8.26335;129.934;460.125;28.5735 444.211;89.164;1.51678;45.3106;331.8;6.14642 2183.16;231.33;45.9052;355.143;748.659;128.079 0 Exp 2,1(0.08);Exp 4,3(0.22);Hill,3(0.22);Linear,2(0.15);Poly 2,5(0.36) 1.9986602152304433 29.98204016685486 1.5232417583465576 5.289852619171143 1.0093490240932248 1.6980669498443604 74.50913255114628 387.46255744885366 43.27966237976045 227.99473433452528 129.1693834716218 1349.7133450998065 CONFLICT 0.5714285714285714 0.42857142857142855 0.0 GO:0001934 9 positive regulation of protein phosphorylation 270 289 7 7 5 5 4 4 48 285 2210 0.28013 0.85837 0.51139 1.38 29200;24484;24330;58919 inhba;igfbp3;egr1;ccnd1 INHBA_33300;IGFBP3_8881;EGR1_8533;CCND1_8224 174.0169125 87.53565 8.26335 231.51377458874293 176.5319183750997 242.63310461909123 109.89507 54.01975 1.51678 151.56620000580472 109.56514721319735 159.66688233452186 350.64005 177.0475 45.9052 441.21985315563103 362.2741758132897 459.855306809434 130.168;44.9033;8.26335;512.733 89.164;18.8755;1.51678;330.024 231.33;122.765;45.9052;1002.56 0 4 0 4 29200;24484;24330;58919 INHBA_33300;IGFBP3_8881;EGR1_8533;CCND1_8224 174.0169125 87.53565 231.51377458874293 109.89507 54.01975 151.56620000580472 350.64005 177.0475 441.21985315563103 130.168;44.9033;8.26335;512.733 89.164;18.8755;1.51678;330.024 231.33;122.765;45.9052;1002.56 0 Exp 2,1(0.25);Exp 4,1(0.25);Hill,1(0.25);Poly 2,1(0.25) 2.1724158822134596 10.135888814926147 1.555469274520874 5.289852619171143 1.8377578879772953 1.6452834606170654 -52.86658659696809 400.90041159696807 -38.63980600568863 258.42994600568863 -81.75540609251846 783.0355060925184 DOWN 0.0 1.0 0.0 GO:0006955 3 immune response 185 212 5 5 3 3 3 3 49 209 2286 0.3594 0.82139 0.79761 1.42 360918;24614;117517 pf4;orm1;c7 PF4_32963;ORM1_9400;C7_8179 83.4854 56.9823 13.8429 86.0129888889463 58.87122275439575 48.22612248921147 44.068353333333334 16.0812 5.32886 58.03651639616676 21.711497847084097 32.66291385539609 243.85276666666667 262.985 41.8963 193.10250784845687 235.27257046702206 125.05136538452385 179.631;56.9823;13.8429 110.795;16.0812;5.32886 426.677;262.985;41.8963 2 1 2 360918;24614 PF4_32963;ORM1_9400 118.30665 118.30665 86.72572747371449 63.4381 63.4381 66.97277025194643 344.831 344.831 115.74772322598835 179.631;56.9823 110.795;16.0812 426.677;262.985 1 117517 C7_8179 13.8429 13.8429 5.32886 5.32886 41.8963 41.8963 13.8429 5.32886 41.8963 0 Exp 4,1(0.34);Hill,1(0.34);Poly 2,1(0.34) 1.9358379435679989 5.9059739112854 1.5846891403198242 2.4614932537078857 0.4484253469453358 1.8597915172576904 -13.847459686121383 180.8182596861214 -21.606147460410483 109.74285412707715 25.33670828716987 462.3688250461635 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0070141 7 response to UV-A 3 3 1 1 1 1 1 1 51 2 2493 0.99879 0.06003 0.06003 33.33 58919 ccnd1 CCND1_8224 512.733 512.733 512.733 512.733 330.024 330.024 330.024 330.024 1002.56 1002.56 1002.56 1002.56 0.0 512.733 0.0 512.733 512.733 330.024 1002.56 0 1 0 1 58919 CCND1_8224 512.733 512.733 330.024 330.024 1002.56 1002.56 512.733 330.024 1002.56 0 Exp 2,1(1) 1.555469274520874 1.555469274520874 1.555469274520874 1.555469274520874 0.0 1.555469274520874 512.733 512.733 330.024 330.024 1002.56 1002.56 DOWN 0.0 1.0 0.0 GO:0009628 3 response to abiotic stimulus 422 443 23 20 16 18 14 14 38 429 2066 0.973 0.055254 0.092988 3.16 24522;24314;83619;25333;59107;24539;24484;25587;116686;24330;24296;58919;25612;114628 zfp354a;nqo1;nfe2l2;mgp;ltbp1;lpl;igfbp3;id2;gsr;egr1;cyp1a1;ccnd1;asns;abcg5 ZFP354A_10203;NQO1_33055;NFE2L2_9301;MGP_33209;LTBP1_33264;LPL_32544;IGFBP3_8881;ID2_8861;GSR_8755;EGR1_8533;CYP1A1_8415;CCND1_8224;ASNS_8091;ABCG5_7947 224.12344428571427 74.86735 2.99674 319.5771206847915 263.01287580092327 336.1861770085856 128.29539242857143 36.23505 0.998544 179.79839780511847 152.05151471566836 188.65397213536068 720.8394357142857 141.075 6.6682 1382.0071312671203 843.506782432764 1458.6276457153708 3.26713;24.1117;6.6423;75.1005;998.777;769.435;44.9033;2.99674;74.6342;8.26335;100.909;512.733;154.987;360.968 1.71987;16.4151;3.4063;13.9312;507.146;444.211;18.8755;0.998544;57.2867;1.51678;73.3629;330.024;53.5946;273.647 6.6682;37.0434;13.4683;346.231;5065.92;2183.16;122.765;10.914;106.529;45.9052;159.385;1002.56;462.615;528.588 6 8 6 24314;83619;25587;116686;24296;25612 NQO1_33055;NFE2L2_9301;ID2_8861;GSR_8755;CYP1A1_8415;ASNS_8091 60.71349 49.37295 60.48399412830969 34.17735733333333 35.00485 31.0153742345238 131.65911666666668 71.7862 172.2977830773039 24.1117;6.6423;2.99674;74.6342;100.909;154.987 16.4151;3.4063;0.998544;57.2867;73.3629;53.5946 37.0434;13.4683;10.914;106.529;159.385;462.615 8 24522;25333;59107;24539;24484;24330;58919;114628 ZFP354A_10203;MGP_33209;LTBP1_33264;LPL_32544;IGFBP3_8881;EGR1_8533;CCND1_8224;ABCG5_7947 346.68091 218.03425000000001 383.408186614731 198.88391875 146.26125 214.62129947927966 1162.724675 437.4095 1733.5320839825192 3.26713;75.1005;998.777;769.435;44.9033;8.26335;512.733;360.968 1.71987;13.9312;507.146;444.211;18.8755;1.51678;330.024;273.647 6.6682;346.231;5065.92;2183.16;122.765;45.9052;1002.56;528.588 0 Exp 2,3(0.22);Exp 4,5(0.36);Hill,3(0.22);Linear,1(0.08);Poly 2,2(0.15) 2.345999740635583 37.29452204704285 1.5423688888549805 6.495501518249512 1.6110767598843103 1.969284176826477 56.71871109012662 391.5281774813019 34.11123196970166 222.4795528874412 -3.100171064898177 1444.7790424934697 CONFLICT 0.42857142857142855 0.5714285714285714 0.0 GO:0035556 5 intracellular signal transduction 318 334 14 14 6 7 3 3 49 331 2164 0.074893 0.97493 0.14443 0.9 246273;363140;360918 trib3;rassf1;pf4 TRIB3_10079;RASSF1_32475;PF4_32963 317.7023 179.631 16.8949 388.692223418568 578.3900553940322 373.07638577887786 184.91989666666666 110.795 6.46469 224.87493156437435 334.39808059678654 216.24283773859722 475.28496666666666 426.677 58.9909 442.60444245556704 741.3513912777353 426.1558860457881 16.8949;756.581;179.631 6.46469;437.5;110.795 58.9909;940.187;426.677 3 0 3 246273;363140;360918 TRIB3_10079;RASSF1_32475;PF4_32963 317.7023 179.631 388.692223418568 184.91989666666666 110.795 224.87493156437435 475.28496666666666 426.677 442.60444245556704 16.8949;756.581;179.631 6.46469;437.5;110.795 58.9909;940.187;426.677 0 0 Exp 4,1(0.34);Poly 2,2(0.67) 2.1000873158348234 6.323691129684448 1.8597915172576904 2.2692105770111084 0.2180725316339715 2.1946890354156494 -122.14435725234387 757.5489572523439 -69.55004378780606 439.3898371211394 -25.569109565975168 976.1390428993085 UP 1.0 0.0 0.0 GO:0045787 6 positive regulation of cell cycle 111 119 8 8 6 6 5 5 47 114 2381 0.96785 0.09265 0.09265 4.2 363140;25587;24296;58919;25612 rassf1;id2;cyp1a1;ccnd1;asns RASSF1_32475;ID2_8861;CYP1A1_8415;CCND1_8224;ASNS_8091 305.641348 154.987 2.99674 317.1905372620461 392.202761749887 329.120413291026 179.0960088 73.3629 0.998544 192.48420848945085 235.38837267553774 192.42690626379405 515.1322 462.615 10.914 447.71853966269913 600.6538541760868 442.62854493746033 756.581;2.99674;100.909;512.733;154.987 437.5;0.998544;73.3629;330.024;53.5946 940.187;10.914;159.385;1002.56;462.615 4 1 4 363140;25587;24296;25612 RASSF1_32475;ID2_8861;CYP1A1_8415;ASNS_8091 253.868435 127.94800000000001 340.99396734851024 141.364011 63.47875 199.7720441834121 393.27525 311.0 410.2134557214288 756.581;2.99674;100.909;154.987 437.5;0.998544;73.3629;53.5946 940.187;10.914;159.385;462.615 1 58919 CCND1_8224 512.733 512.733 330.024 330.024 1002.56 1002.56 512.733 330.024 1002.56 0 Exp 2,1(0.2);Exp 4,1(0.2);Hill,1(0.2);Poly 2,2(0.4) 2.0232154816348484 10.268240571022034 1.555469274520874 2.634152889251709 0.3976700219279743 1.9777342081069946 27.611583570054847 583.6711124299452 10.376161087159517 347.81585651284047 122.68959692668938 907.5748030733107 UP 0.8 0.2 0.0 GO:0032268 6 regulation of cellular protein metabolic process 600 637 30 27 11 15 7 7 45 630 1865 0.031741 0.98709 0.052752 1.1 246273;299270;363140;29200;24484;24330;58919 trib3;serpina6;rassf1;inhba;igfbp3;egr1;ccnd1 TRIB3_10079;SERPINA6_32325;RASSF1_32475;INHBA_33300;IGFBP3_8881;EGR1_8533;CCND1_8224 212.19870714285713 44.9033 8.26335 299.9102018158052 314.3200470748428 342.0571501143185 127.32829571428572 18.8755 1.51678 180.3909334120816 186.3392406964015 204.02343262090167 348.93918571428577 122.765 40.8362 430.62123424684324 485.8629016854542 462.8534184708886 16.8949;15.8474;756.581;130.168;44.9033;8.26335;512.733 6.46469;7.7531;437.5;89.164;18.8755;1.51678;330.024 58.9909;40.8362;940.187;231.33;122.765;45.9052;1002.56 2 5 2 246273;363140 TRIB3_10079;RASSF1_32475 386.73795 386.73795 523.0370572594306 221.982345 221.982345 304.7879906318457 499.58895 499.58895 623.099737865139 16.8949;756.581 6.46469;437.5 58.9909;940.187 5 299270;29200;24484;24330;58919 SERPINA6_32325;INHBA_33300;IGFBP3_8881;EGR1_8533;CCND1_8224 142.38300999999998 44.9033 212.608771703199 89.466676 18.8755 138.9814057535967 288.67928 122.765 406.4503711512292 15.8474;130.168;44.9033;8.26335;512.733 7.7531;89.164;18.8755;1.51678;330.024 40.8362;231.33;122.765;45.9052;1002.56 0 Exp 2,1(0.15);Exp 4,3(0.43);Hill,1(0.15);Poly 2,2(0.29) 2.133347624702389 16.412846565246582 1.555469274520874 5.289852619171143 1.3282948370313337 1.8130581378936768 -9.977879560770361 434.3752938464846 -6.307177887884734 260.96376931645614 29.930511091651056 667.9478603369204 DOWN 0.2857142857142857 0.7142857142857143 0.0 GO:0031667 5 response to nutrient levels 239 256 28 27 17 21 14 14 38 242 2253 0.9999 3.9807E-4 3.9807E-4 5.47 24522;24614;24314;83619;25333;59107;24539;24484;116686;24330;24296;58919;25612;114628 zfp354a;orm1;nqo1;nfe2l2;mgp;ltbp1;lpl;igfbp3;gsr;egr1;cyp1a1;ccnd1;asns;abcg5 ZFP354A_10203;ORM1_9400;NQO1_33055;NFE2L2_9301;MGP_33209;LTBP1_33264;LPL_32544;IGFBP3_8881;GSR_8755;EGR1_8533;CYP1A1_8415;CCND1_8224;ASNS_8091;ABCG5_7947 227.9795557142857 74.86735 3.26713 317.0191619150715 248.73603597938572 327.43987746615886 129.372725 36.23505 1.51678 179.0204797950646 142.20659442320192 184.98338653236897 738.8445071428571 211.185 6.6682 1373.6634411736188 805.3371473819425 1409.3722412021643 11.5 641.084 3.26713;56.9823;24.1117;6.6423;75.1005;998.777;769.435;44.9033;74.6342;8.26335;100.909;512.733;154.987;360.968 1.71987;16.0812;16.4151;3.4063;13.9312;507.146;444.211;18.8755;57.2867;1.51678;73.3629;330.024;53.5946;273.647 6.6682;262.985;37.0434;13.4683;346.231;5065.92;2183.16;122.765;106.529;45.9052;159.385;1002.56;462.615;528.588 6 8 6 24614;24314;83619;116686;24296;25612 ORM1_9400;NQO1_33055;NFE2L2_9301;GSR_8755;CYP1A1_8415;ASNS_8091 69.71108333333332 65.80825 53.83033747259689 36.69113333333333 35.00485 28.2789322001144 173.67095000000003 132.957 167.63637425155375 56.9823;24.1117;6.6423;74.6342;100.909;154.987 16.0812;16.4151;3.4063;57.2867;73.3629;53.5946 262.985;37.0434;13.4683;106.529;159.385;462.615 8 24522;25333;59107;24539;24484;24330;58919;114628 ZFP354A_10203;MGP_33209;LTBP1_33264;LPL_32544;IGFBP3_8881;EGR1_8533;CCND1_8224;ABCG5_7947 346.68091 218.03425000000001 383.408186614731 198.88391875 146.26125 214.62129947927966 1162.724675 437.4095 1733.5320839825192 3.26713;75.1005;998.777;769.435;44.9033;8.26335;512.733;360.968 1.71987;13.9312;507.146;444.211;18.8755;1.51678;330.024;273.647 6.6682;346.231;5065.92;2183.16;122.765;45.9052;1002.56;528.588 0 Exp 2,3(0.22);Exp 4,6(0.43);Hill,2(0.15);Linear,1(0.08);Poly 2,2(0.15) 2.309164265174123 36.901476979255676 1.5423688888549805 6.495501518249512 1.6272965274671674 1.933514654636383 61.914763264308164 394.0443481642633 35.59606291473743 223.14938708526256 19.275592517655696 1458.4134217680587 CONFLICT 0.42857142857142855 0.5714285714285714 0.0 GO:0046903 5 secretion 115 123 5 5 4 3 3 3 49 120 2375 0.75908 0.46354 0.73783 2.44 29200;58919;140668 inhba;ccnd1;abcc3 INHBA_33300;CCND1_8224;ABCC3_7941 243.13096666666664 130.168 86.4919 234.5012637725079 252.41001164927405 246.24155294139132 153.21259999999998 89.164 40.4498 155.04828827781364 156.32479666515428 165.1496373966785 447.3033333333333 231.33 108.02 484.80286038072563 461.4723808983666 513.0621878818685 130.168;512.733;86.4919 89.164;330.024;40.4498 231.33;1002.56;108.02 1 2 1 140668 ABCC3_7941 86.4919 86.4919 40.4498 40.4498 108.02 108.02 86.4919 40.4498 108.02 2 29200;58919 INHBA_33300;CCND1_8224 321.4505 321.4505 270.51430574463154 209.594 209.594 170.31373931659186 616.9449999999999 616.9449999999999 545.341962854501 130.168;512.733 89.164;330.024 231.33;1002.56 0 Exp 2,1(0.34);Exp 5,1(0.34);Poly 2,1(0.34) 2.0465539709647724 6.560148477554321 1.555469274520874 3.368933916091919 1.0246170885274466 1.6357452869415283 -22.2321941514885 508.49412748482183 -22.241055110189336 328.66625511018935 -101.30274807830324 995.9094147449698 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0007178 7 transmembrane receptor protein serine/threonine kinase signaling pathway 41 43 3 3 2 3 2 2 50 41 2454 0.94414 0.21851 0.21851 4.65 29200;24330 inhba;egr1 INHBA_33300;EGR1_8533 69.215675 69.215675 8.26335 86.19960467317266 53.074695741602724 83.12225588235216 45.34039 45.34039 1.51678 61.975943614149195 33.73532029940873 59.76338595957426 138.6176 138.6176 45.9052 131.11513348015936 114.06613415523965 126.43428837648091 130.168;8.26335 89.164;1.51678 231.33;45.9052 0 2 0 2 29200;24330 INHBA_33300;EGR1_8533 69.215675 69.215675 86.19960467317266 45.34039 45.34039 61.975943614149195 138.6176 138.6176 131.11513348015936 130.168;8.26335 89.164;1.51678 231.33;45.9052 0 Hill,1(0.5);Poly 2,1(0.5) 2.941572961941365 6.925597906112671 1.6357452869415283 5.289852619171143 2.5838440738030446 3.4627989530563354 -50.25088199999999 188.682232 -40.5538856 131.2346656 -43.098704 320.333904 DOWN 0.0 1.0 0.0 GO:1901564 4 organonitrogen compound metabolic process 832 911 45 41 20 31 15 15 37 896 1599 0.18318 0.88598 0.3109 1.65 246273;266730;83619;29200;24484;24424;300850;116686;297417;24296;58919;25612;64392;24763;296925 trib3;slc17a3;nfe2l2;inhba;igfbp3;gstm2;gsta4;gsr;gfpt1;cyp1a1;ccnd1;asns;aldh1l1;acsm3;aass TRIB3_10079;SLC17A3_9840;NFE2L2_9301;INHBA_33300;IGFBP3_8881;GSTM2_8759;GSTA4_8757;GSR_8755;GFPT1_8705;CYP1A1_8415;CCND1_8224;ASNS_8091;ALDH1L1_32662;ACSM3_7976;AASS_7936 190.899772 100.909 3.28268 267.2106587293431 152.1481888176017 195.15396153112826 117.28432579999999 57.2867 0.808077 160.52209828514765 97.53587575348656 126.2273476648054 579.2656599999999 159.385 13.1174 1076.1083178559613 357.09024396384945 602.3984788840988 16.8949;58.7587;6.6423;130.168;44.9033;3.28268;105.355;74.6342;981.5;100.909;512.733;154.987;184.03;460.125;28.5735 6.46469;46.6655;3.4063;89.164;18.8755;0.808077;75.6422;57.2867;554.87;73.3629;330.024;53.5946;111.154;331.8;6.14642 58.9909;78.8953;13.4683;231.33;122.765;13.1174;172.041;106.529;4240.48;159.385;1002.56;462.615;1150.07;748.659;128.079 10 5 10 246273;266730;83619;24424;300850;116686;297417;24296;25612;64392 TRIB3_10079;SLC17A3_9840;NFE2L2_9301;GSTM2_8759;GSTA4_8757;GSR_8755;GFPT1_8705;CYP1A1_8415;ASNS_8091;ALDH1L1_32662 168.699378 87.7716 291.9819142834675 98.3254967 55.440650000000005 164.33252780108756 645.55919 132.957 1309.2527793987422 16.8949;58.7587;6.6423;3.28268;105.355;74.6342;981.5;100.909;154.987;184.03 6.46469;46.6655;3.4063;0.808077;75.6422;57.2867;554.87;73.3629;53.5946;111.154 58.9909;78.8953;13.4683;13.1174;172.041;106.529;4240.48;159.385;462.615;1150.07 5 29200;24484;58919;24763;296925 INHBA_33300;IGFBP3_8881;CCND1_8224;ACSM3_7976;AASS_7936 235.30056 130.168 233.21387003648172 155.20198399999998 89.164 163.48783078824638 446.6786 231.33 404.0411605756275 130.168;44.9033;512.733;460.125;28.5735 89.164;18.8755;330.024;331.8;6.14642 231.33;122.765;1002.56;748.659;128.079 0 Exp 2,1(0.07);Exp 4,4(0.27);Hill,2(0.14);Linear,2(0.14);Poly 2,6(0.4) 1.7950252554511437 27.253735661506653 1.5232417583465576 2.634152889251709 0.31040566025006167 1.7059084177017212 55.67252099145301 326.127023008547 36.04893578806481 198.5197158119352 34.679713080535066 1123.851606919465 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0010996 5 response to auditory stimulus 12 13 1 1 1 1 1 1 51 12 2483 0.97238 0.2357 0.2357 7.69 116686 gsr GSR_8755 74.6342 74.6342 74.6342 74.6342 57.2867 57.2867 57.2867 57.286699999999996 106.529 106.529 106.529 106.52900000000001 0.0 74.6342 74.6342 57.2867 106.529 1 0 1 116686 GSR_8755 74.6342 74.6342 57.2867 57.2867 106.529 106.529 74.6342 57.2867 106.529 0 0 Poly 2,1(1) 1.9608341455459595 1.9608341455459595 1.9608341455459595 1.9608341455459595 0.0 1.9608341455459595 74.6342 74.6342 57.2867 57.2867 106.529 106.529 UP 1.0 0.0 0.0 GO:0006468 7 protein phosphorylation 190 202 10 9 4 6 3 3 49 199 2296 0.39868 0.79443 0.79506 1.49 246273;24484;58919 trib3;igfbp3;ccnd1 TRIB3_10079;IGFBP3_8881;CCND1_8224 191.51039999999998 44.9033 16.8949 278.53920133566476 209.69074799824503 278.5722938234523 118.45473 18.8755 6.46469 183.3294140542202 129.27855157398267 184.45587939164432 394.7719666666667 122.765 58.9909 527.3248562841536 431.2254312822201 525.3891483989354 16.8949;44.9033;512.733 6.46469;18.8755;330.024 58.9909;122.765;1002.56 1 2 1 246273 TRIB3_10079 16.8949 16.8949 6.46469 6.46469 58.9909 58.9909 16.8949 6.46469 58.9909 2 24484;58919 IGFBP3_8881;CCND1_8224 278.81814999999995 278.81814999999995 330.8055533104682 174.44975 174.44975 220.01521430602247 562.6625 562.6625 622.1090105540184 44.9033;512.733 18.8755;330.024 122.765;1002.56 0 Exp 2,1(0.34);Exp 4,2(0.67) 1.8009257538273382 5.479501485824585 1.555469274520874 2.2692105770111084 0.3866030072325336 1.6548216342926025 -123.68637842717845 506.70717842717846 -89.00203164697753 325.91149164697754 -201.95228287636547 991.4962162096988 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0048545 5 response to steroid hormone 158 177 11 11 6 9 6 6 46 171 2324 0.93477 0.14861 0.17132 3.39 286954;24614;25333;25315;24330;58919 ugt2b1;orm1;mgp;ephx1;egr1;ccnd1 UGT2B10_33303,UGT2B1_33224;ORM1_9400;MGP_33209;EPHX1_8567;EGR1_8533;CCND1_8224 117.24235833333334 41.239450000000005 8.26335 195.26641684043472 132.82303447302164 198.26888733693565 64.72984666666666 14.708950000000002 1.51678 130.0765325191576 70.23442053831495 134.6060434909063 293.83974166666667 163.481375 41.3795 369.8717370635263 355.20123569083745 357.82831008926604 25.4966;56.9823;75.1005;24.8784;8.26335;512.733 11.3392;16.0812;13.9312;15.4867;1.51678;330.024 63.97775;262.985;346.231;41.3795;45.9052;1002.56 4 3 3 286954;24614;25315 UGT2B10_33303,UGT2B1_33224;ORM1_9400;EPHX1_8567 35.78576666666667 25.4966 18.359338545365212 14.302366666666666 15.4867 2.5833360376329906 122.78075000000001 63.97775 121.94504505847091 25.4966;56.9823;24.8784 11.3392;16.0812;15.4867 63.97775;262.985;41.3795 3 25333;24330;58919 MGP_33209;EGR1_8533;CCND1_8224 198.69894999999997 75.1005 274.0070064333803 115.15732666666668 13.9312 186.18349802811238 464.89873333333327 346.231 489.24290980208735 75.1005;8.26335;512.733 13.9312;1.51678;330.024 346.231;45.9052;1002.56 0 Exp 2,1(0.15);Exp 4,4(0.58);Hill,2(0.29) 2.132839533387032 16.487234711647034 1.555469274520874 5.289852619171143 1.3475186017301752 1.7026138305664062 -39.00331615248527 273.48803281915195 -39.35305651294317 168.81274984627652 -2.119286853618121 589.7987701869515 CONFLICT 0.5 0.5 0.0 GO:1901565 5 organonitrogen compound catabolic process 128 143 8 8 4 6 3 3 49 140 2355 0.66618 0.56677 0.76655 2.1 83619;64392;296925 nfe2l2;aldh1l1;aass NFE2L2_9301;ALDH1L1_32662;AASS_7936 73.08193333333334 28.5735 6.6423 96.7075462730977 53.97428055034867 80.48280066125045 40.23557333333333 6.14642 3.4063 61.43243845933623 26.453637599160235 51.91883231537333 430.53909999999996 128.079 13.4683 625.7614882522972 302.77985811651797 522.4980572435408 6.6423;184.03;28.5735 3.4063;111.154;6.14642 13.4683;1150.07;128.079 2 1 2 83619;64392 NFE2L2_9301;ALDH1L1_32662 95.33615 95.33615 125.43204556908493 57.28015 57.28015 76.18912932725377 581.76915 581.76915 803.6987695781579 6.6423;184.03 3.4063;111.154 13.4683;1150.07 1 296925 AASS_7936 28.5735 28.5735 6.14642 6.14642 128.079 128.079 28.5735 6.14642 128.079 0 Exp 4,1(0.34);Hill,1(0.34);Poly 2,1(0.34) 1.6379243597224342 4.9212318658828735 1.5423688888549805 1.7613576650619507 0.1112767313755775 1.6175053119659424 -36.35295729861133 182.516823965278 -29.28177503435353 109.7529217010202 -277.57668483429075 1138.6548848342907 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0019752 6 carboxylic acid metabolic process 287 320 37 34 20 28 16 16 36 304 2191 0.99989 3.857E-4 3.857E-4 5.0 286954;501907;24539;24424;297417;25598;25315;499353;29277;24296;290277;25612;64392;24188;24763;296925 ugt2b1;rgd1559459;lpl;gstm2;gfpt1;fabp2;ephx1;cyp2c24;cyp2c11;cyp1a1;cryl1;asns;aldh1l1;aldh1a1;acsm3;aass UGT2B10_33303,UGT2B1_33224;RGD1559459_9690;LPL_32544;GSTM2_8759;GFPT1_8705;FABP2_32859;EPHX1_8567;CYP2C24_32875;CYP2C11_32593;CYP1A1_8415;CRYL1_8388;ASNS_8091;ALDH1L1_32662;ALDH1A1_8022;ACSM3_7976;AASS_7936 246.94051125 115.42150000000001 3.28268 311.3489850532561 268.8220168493859 307.88659080511366 144.8110685625 59.77165 0.808077 188.30905764666855 163.3903748700311 188.40342128957235 756.691965625 284.999 13.1174 1130.188274580806 704.4462883684295 897.3410004091235 15.0 981.5 25.4966;42.78;769.435;3.28268;981.5;146.645;24.8784;733.935;129.934;100.909;76.0301;154.987;184.03;88.5069;460.125;28.5735 11.3392;20.6065;444.211;0.808077;554.87;95.8536;15.4867;463.206;45.3106;73.3629;23.2788;53.5946;111.154;65.9487;331.8;6.14642 63.97775;93.6128;2183.16;13.1174;4240.48;319.535;41.3795;1763.75;355.143;159.385;250.463;462.615;1150.07;133.645;748.659;128.079 12 5 11 286954;501907;24424;297417;25598;25315;24296;290277;25612;64392;24188 UGT2B10_33303,UGT2B1_33224;RGD1559459_9690;GSTM2_8759;GFPT1_8705;FABP2_32859;EPHX1_8567;CYP1A1_8415;CRYL1_8388;ASNS_8091;ALDH1L1_32662;ALDH1A1_8022 166.27688 88.5069 276.6791639366514 93.30027972727272 53.5946 157.35590330547413 629.8436772727272 159.385 1240.058481305868 25.4966;42.78;3.28268;981.5;146.645;24.8784;100.909;76.0301;154.987;184.03;88.5069 11.3392;20.6065;0.808077;554.87;95.8536;15.4867;73.3629;23.2788;53.5946;111.154;65.9487 63.97775;93.6128;13.1174;4240.48;319.535;41.3795;159.385;250.463;462.615;1150.07;133.645 5 24539;499353;29277;24763;296925 LPL_32544;CYP2C24_32875;CYP2C11_32593;ACSM3_7976;AASS_7936 424.4004999999999 460.125 338.9418041242479 258.134804 331.8 218.45903204467447 1035.7581999999998 748.659 896.6670902200549 769.435;733.935;129.934;460.125;28.5735 444.211;463.206;45.3106;331.8;6.14642 2183.16;1763.75;355.143;748.659;128.079 0 Exp 2,1(0.06);Exp 4,6(0.36);Hill,3(0.18);Linear,3(0.18);Poly 2,4(0.24) 1.8934182436836287 32.76926517486572 1.5232417583465576 2.79919695854187 0.39869250083512825 1.7059084177017212 94.37950857390447 399.5015139260954 52.53963031563241 237.0825068093676 202.89971108040504 1310.484220169595 UP 0.6875 0.3125 0.0 GO:0071248 6 cellular response to metal ion 94 103 8 8 5 8 5 5 47 98 2397 0.98302 0.056587 0.056587 4.85 24314;83619;25587;300850;24296 nqo1;nfe2l2;id2;gsta4;cyp1a1 NQO1_33055;NFE2L2_9301;ID2_8861;GSTA4_8757;CYP1A1_8415 48.002948 24.1117 2.99674 50.978823788299785 64.30936531637252 49.690529880447485 33.9650088 16.4151 0.998544 37.47600526053153 46.11954899455502 36.706106295995646 78.57034 37.0434 10.914 80.3242121839237 103.1193953295156 77.77773716743663 24.1117;6.6423;2.99674;105.355;100.909 16.4151;3.4063;0.998544;75.6422;73.3629 37.0434;13.4683;10.914;172.041;159.385 5 0 5 24314;83619;25587;300850;24296 NQO1_33055;NFE2L2_9301;ID2_8861;GSTA4_8757;CYP1A1_8415 48.002948 24.1117 50.978823788299785 33.9650088 16.4151 37.47600526053153 78.57034 37.0434 80.3242121839237 24.1117;6.6423;2.99674;105.355;100.909 16.4151;3.4063;0.998544;75.6422;73.3629 37.0434;13.4683;10.914;172.041;159.385 0 0 Exp 4,2(0.4);Hill,1(0.2);Poly 2,2(0.4) 2.2486056267959666 12.271108269691467 1.5423688888549805 4.773829460144043 1.3120883072826846 1.9777342081069946 3.3180387617803078 92.68785723821969 1.1158418472262213 66.81417575277378 8.163063716510862 148.97761628348914 UP 1.0 0.0 0.0 GO:0009605 3 response to external stimulus 571 616 44 40 25 31 19 19 33 597 1898 0.9854 0.030043 0.047982 3.08 24522;286954;360918;24614;24314;83619;25333;59107;24539;24484;25587;116686;24330;24296;58919;54232;25612;114628;140668 zfp354a;ugt2b1;pf4;orm1;nqo1;nfe2l2;mgp;ltbp1;lpl;igfbp3;id2;gsr;egr1;cyp1a1;ccnd1;car3;asns;abcg5;abcc3 ZFP354A_10203;UGT2B10_33303,UGT2B1_33224;PF4_32963;ORM1_9400;NQO1_33055;NFE2L2_9301;MGP_33209;LTBP1_33264;LPL_32544;IGFBP3_8881;ID2_8861;GSR_8755;EGR1_8533;CYP1A1_8415;CCND1_8224;CAR3_8196;ASNS_8091;ABCG5_7947;ABCC3_7941 186.39684315789472 74.6342 2.99674 280.6227096667101 221.37275074001982 307.1619123222615 105.23483126315789 24.6611 0.998544 159.02253234647884 125.76810403831706 174.08945766557744 582.1118868421053 122.765 6.6682 1200.5539028685919 701.4538300852468 1313.4054642071042 3.26713;25.4966;179.631;56.9823;24.1117;6.6423;75.1005;998.777;769.435;44.9033;2.99674;74.6342;8.26335;100.909;512.733;55.21;154.987;360.968;86.4919 1.71987;11.3392;110.795;16.0812;16.4151;3.4063;13.9312;507.146;444.211;18.8755;0.998544;57.2867;1.51678;73.3629;330.024;24.6611;53.5946;273.647;40.4498 6.6682;63.97775;426.677;262.985;37.0434;13.4683;346.231;5065.92;2183.16;122.765;10.914;106.529;45.9052;159.385;1002.56;106.714;462.615;528.588;108.02 11 9 10 286954;360918;24614;24314;83619;25587;116686;24296;25612;140668 UGT2B10_33303,UGT2B1_33224;PF4_32963;ORM1_9400;NQO1_33055;NFE2L2_9301;ID2_8861;GSR_8755;CYP1A1_8415;ASNS_8091;ABCC3_7941 71.288274 65.80825 60.766729647907425 38.372934400000005 28.432450000000003 35.578391648634934 165.16144500000001 107.27449999999999 165.53958391327845 25.4966;179.631;56.9823;24.1117;6.6423;2.99674;74.6342;100.909;154.987;86.4919 11.3392;110.795;16.0812;16.4151;3.4063;0.998544;57.2867;73.3629;53.5946;40.4498 63.97775;426.677;262.985;37.0434;13.4683;10.914;106.529;159.385;462.615;108.02 9 24522;25333;59107;24539;24484;24330;58919;54232;114628 ZFP354A_10203;MGP_33209;LTBP1_33264;LPL_32544;IGFBP3_8881;EGR1_8533;CCND1_8224;CAR3_8196;ABCG5_7947 314.29525333333333 75.1005 371.572448773288 179.52582777777778 24.6611 208.99075479839365 1045.3901555555556 346.231 1659.3367064889235 3.26713;75.1005;998.777;769.435;44.9033;8.26335;512.733;55.21;360.968 1.71987;13.9312;507.146;444.211;18.8755;1.51678;330.024;24.6611;273.647 6.6682;346.231;5065.92;2183.16;122.765;45.9052;1002.56;106.714;528.588 0 Exp 2,3(0.15);Exp 4,8(0.4);Exp 5,2(0.1);Hill,3(0.15);Linear,1(0.05);Poly 2,3(0.15) 2.2601671309897884 50.26404058933258 1.5423688888549805 6.495501518249512 1.4041395179137126 1.933514654636383 60.21348399518439 312.5802023206051 33.72958018112162 176.74008234519414 42.277015673685696 1121.9467580105247 CONFLICT 0.5263157894736842 0.47368421052631576 0.0 GO:0032868 6 response to insulin 96 102 15 13 6 8 4 4 48 98 2397 0.94534 0.1526 0.1526 3.92 246273;24484;297417;24330 trib3;igfbp3;gfpt1;egr1 TRIB3_10079;IGFBP3_8881;GFPT1_8705;EGR1_8533 262.8903875 30.8991 8.26335 479.32829862580337 84.29270695409113 255.76920393417453 145.4317425 12.670095 1.51678 273.0564821499203 42.923985908859905 145.8091795531434 1117.035275 90.87795 45.9052 2082.5671551331016 327.7594372578914 1113.0385016100854 16.8949;44.9033;981.5;8.26335 6.46469;18.8755;554.87;1.51678 58.9909;122.765;4240.48;45.9052 2 2 2 246273;297417 TRIB3_10079;GFPT1_8705 499.19745 499.19745 682.0788073771278 280.667345 280.667345 387.7811135397107 2149.7354499999997 2149.7354499999997 2956.7592980676327 16.8949;981.5 6.46469;554.87 58.9909;4240.48 2 24484;24330 IGFBP3_8881;EGR1_8533 26.583325000000002 26.583325000000002 25.90835710733604 10.19614 10.19614 12.274468624718544 84.3351 84.3351 54.348085780641796 44.9033;8.26335 18.8755;1.51678 122.765;45.9052 0 Exp 4,2(0.5);Hill,1(0.25);Linear,1(0.25) 2.345360462372093 10.737126588821411 1.5232417583465576 5.289852619171143 1.767209252368501 1.9620161056518555 -206.85134515328724 732.6321201532871 -122.16361000692191 413.02709500692197 -923.8805370304399 3157.95108703044 CONFLICT 0.5 0.5 0.0 GO:2000113 8 negative regulation of cellular macromolecule biosynthetic process 254 266 18 16 8 12 7 7 45 259 2236 0.8309 0.29676 0.48809 2.63 24522;246273;25587;297417;24330;25695;58919 zfp354a;trib3;id2;gfpt1;egr1;cebpd;ccnd1 ZFP354A_10203;TRIB3_10079;ID2_8861;GFPT1_8705;EGR1_8533;CEBPD_8283;CCND1_8224 218.75935285714286 8.26335 2.99674 385.49820855660016 150.2701758112212 280.8267953779738 128.250262 2.15795 0.998544 224.24404644048835 92.70441240646173 173.063985910582 768.8383285714286 45.9052 6.6682 1573.479619192949 380.67176407997056 892.893804955948 3.26713;16.8949;2.99674;981.5;8.26335;5.66035;512.733 1.71987;6.46469;0.998544;554.87;1.51678;2.15795;330.024 6.6682;58.9909;10.914;4240.48;45.9052;16.35;1002.56 3 4 3 246273;25587;297417 TRIB3_10079;ID2_8861;GFPT1_8705 333.79721333333333 16.8949 560.9701102596025 187.4444113333333 6.46469 318.2116309837028 1436.7949666666664 58.9909 2428.1814536153183 16.8949;2.99674;981.5 6.46469;0.998544;554.87 58.9909;10.914;4240.48 4 24522;24330;25695;58919 ZFP354A_10203;EGR1_8533;CEBPD_8283;CCND1_8224 132.4809575 6.96185 253.50957216793915 83.85465 1.93891 164.11311809449987 267.87084999999996 31.1276 490.0770209056905 3.26713;8.26335;5.66035;512.733 1.71987;1.51678;2.15795;330.024 6.6682;45.9052;16.35;1002.56 0 Exp 2,1(0.15);Exp 4,3(0.43);Hill,2(0.29);Linear,1(0.15) 2.4796439185775085 20.6886066198349 1.5232417583465576 6.495501518249512 2.0541786403721454 1.9777342081069946 -66.82171653932636 504.3404222536121 -37.872052363138266 294.3725763631383 -396.81168574425567 1934.488342887113 CONFLICT 0.42857142857142855 0.5714285714285714 0.0 GO:0097306 6 cellular response to alcohol 47 52 6 5 3 4 2 2 50 50 2445 0.91185 0.28727 0.28727 3.85 286954;29200 ugt2b1;inhba UGT2B10_33303,UGT2B1_33224;INHBA_33300 77.8323 77.8323 25.4966 74.01385673628961 68.13266758207291 72.7315973349561 50.2516 50.2516 11.3392 55.03044382448682 43.03977372272949 54.077064186334496 147.653875 147.653875 63.97775 118.33591082182643 132.14576763434866 116.28579019769406 25.4966;130.168 11.3392;89.164 63.97775;231.33 2 1 1 286954 UGT2B10_33303,UGT2B1_33224 25.4966 25.4966 11.3392 11.3392 63.97775 63.97775 25.4966 11.3392 63.97775 1 29200 INHBA_33300 130.168 130.168 89.164 89.164 231.33 231.33 130.168 89.164 231.33 0 Exp 4,2(0.67);Poly 2,1(0.34) 1.678729150040527 5.037033200263977 1.6357452869415283 1.7026138305664062 0.037521009852228754 1.6986740827560425 -24.745672 180.41027200000002 -26.016704000000004 126.519904 -16.35132999999999 311.65908 CONFLICT 0.5 0.5 0.0 GO:0050896 2 response to stimulus 1203 1308 76 69 40 56 33 33 19 1275 1220 0.97233 0.05146 0.092196 2.52 24522;286954;246273;170698;363140;360918;24614;338475;24314;316351;83619;25333;307126;59107;24539;29200;24484;494344;25587;24424;300850;116686;297417;25315;24330;24296;58919;54232;117517;25612;24188;114628;140668 zfp354a;ugt2b1;trib3;slco1a2;rassf1;pf4;orm1;nrep;nqo1;npas2;nfe2l2;mgp;mcm10;ltbp1;lpl;inhba;igfbp3;ier2;id2;gstm2;gsta4;gsr;gfpt1;ephx1;egr1;cyp1a1;ccnd1;car3;c7;asns;aldh1a1;abcg5;abcc3 ZFP354A_10203;UGT2B10_33303,UGT2B1_33224;TRIB3_10079;SLCO1A2_9886;RASSF1_32475;PF4_32963;ORM1_9400;NREP_9364;NQO1_33055;NPAS2_9350;NFE2L2_9301;MGP_33209;MCM10_32579;LTBP1_33264;LPL_32544;INHBA_33300;IGFBP3_8881;IER2_32643;ID2_8861;GSTM2_8759;GSTA4_8757;GSR_8755;GFPT1_8705;EPHX1_8567;EGR1_8533;CYP1A1_8415;CCND1_8224;CAR3_8196;C7_8179;ASNS_8091;ALDH1A1_8022;ABCG5_7947;ABCC3_7941 215.38708484848488 88.5069 2.99674 289.705492712634 243.15727480394048 294.97335286324056 126.82838851515154 56.7249 0.808077 168.45353334157 141.83275505867817 170.55330431969443 601.9861196969697 172.041 6.6682 1139.328953924091 642.646438182868 1111.835521777178 3.26713;25.4966;16.8949;440.994;756.581;179.631;56.9823;112.624;24.1117;134.458;6.6423;75.1005;213.608;998.777;769.435;130.168;44.9033;543.54;2.99674;3.28268;105.355;74.6342;981.5;24.8784;8.26335;100.909;512.733;55.21;13.8429;154.987;88.5069;360.968;86.4919 1.71987;11.3392;6.46469;299.351;437.5;110.795;16.0812;79.4619;16.4151;56.7249;3.4063;13.9312;123.177;507.146;444.211;89.164;18.8755;375.947;0.998544;0.808077;75.6422;57.2867;554.87;15.4867;1.51678;73.3629;330.024;24.6611;5.32886;53.5946;65.9487;273.647;40.4498 6.6682;63.97775;58.9909;772.521;940.187;426.677;262.985;192.339;37.0434;320.448;13.4683;346.231;668.095;5065.92;2183.16;231.33;122.765;978.946;10.914;13.1174;172.041;106.529;4240.48;41.3795;45.9052;159.385;1002.56;106.714;41.8963;462.615;133.645;528.588;108.02 18 16 17 286954;246273;363140;360918;24614;24314;83619;25587;24424;300850;116686;297417;25315;24296;25612;24188;140668 UGT2B10_33303,UGT2B1_33224;TRIB3_10079;RASSF1_32475;PF4_32963;ORM1_9400;NQO1_33055;NFE2L2_9301;ID2_8861;GSTM2_8759;GSTA4_8757;GSR_8755;GFPT1_8705;EPHX1_8567;CYP1A1_8415;ASNS_8091;ALDH1A1_8022;ABCC3_7941 158.2283305882353 74.6342 275.45909588919596 90.61468888235294 40.4498 157.35510609940468 426.5561911764706 108.02 1010.7146498381326 25.4966;16.8949;756.581;179.631;56.9823;24.1117;6.6423;2.99674;3.28268;105.355;74.6342;981.5;24.8784;100.909;154.987;88.5069;86.4919 11.3392;6.46469;437.5;110.795;16.0812;16.4151;3.4063;0.998544;0.808077;75.6422;57.2867;554.87;15.4867;73.3629;53.5946;65.9487;40.4498 63.97775;58.9909;940.187;426.677;262.985;37.0434;13.4683;10.914;13.1174;172.041;106.529;4240.48;41.3795;159.385;462.615;133.645;108.02 16 24522;170698;338475;316351;25333;307126;59107;24539;29200;24484;494344;24330;58919;54232;117517;114628 ZFP354A_10203;SLCO1A2_9886;NREP_9364;NPAS2_9350;MGP_33209;MCM10_32579;LTBP1_33264;LPL_32544;INHBA_33300;IGFBP3_8881;IER2_32643;EGR1_8533;CCND1_8224;CAR3_8196;C7_8179;ABCG5_7947 276.11826125000005 132.313 300.7922646747682 165.305444375 84.31295 176.23825087241897 788.38041875 333.3395 1267.9242264733373 3.26713;440.994;112.624;134.458;75.1005;213.608;998.777;769.435;130.168;44.9033;543.54;8.26335;512.733;55.21;13.8429;360.968 1.71987;299.351;79.4619;56.7249;13.9312;123.177;507.146;444.211;89.164;18.8755;375.947;1.51678;330.024;24.6611;5.32886;273.647 6.6682;772.521;192.339;320.448;346.231;668.095;5065.92;2183.16;231.33;122.765;978.946;45.9052;1002.56;106.714;41.8963;528.588 0 Exp 2,4(0.12);Exp 4,10(0.3);Exp 5,2(0.06);Hill,6(0.18);Linear,3(0.09);Poly 2,9(0.27) 2.144398574894107 78.62418627738953 1.5232417583465576 6.495501518249512 1.1223916746691025 1.933514654636383 116.5418287942294 314.2323409027403 69.3533559209027 184.30342110940023 213.2559609203061 990.7162784736333 CONFLICT 0.5151515151515151 0.48484848484848486 0.0 GO:0006883 9 cellular sodium ion homeostasis 4 4 1 1 1 1 1 1 51 3 2492 0.99761 0.079243 0.079243 25.0 117517 c7 C7_8179 13.8429 13.8429 13.8429 13.8429 5.32886 5.32886 5.32886 5.32886 41.8963 41.8963 41.8963 41.8963 0.0 13.8429 0.0 13.8429 13.8429 5.32886 41.8963 0 1 0 1 117517 C7_8179 13.8429 13.8429 5.32886 5.32886 41.8963 41.8963 13.8429 5.32886 41.8963 0 Hill,1(1) 2.4614932537078857 2.4614932537078857 2.4614932537078857 2.4614932537078857 0.0 2.4614932537078857 13.8429 13.8429 5.32886 5.32886 41.8963 41.8963 DOWN 0.0 1.0 0.0 GO:0048856 3 anatomical structure development 699 756 39 37 21 28 16 16 36 740 1755 0.63464 0.48399 0.87849 2.12 24522;308843;24614;338475;25333;59107;29200;25587;25315;24330;24296;29276;25695;58919;25612;24188 zfp354a;tsku;orm1;nrep;mgp;ltbp1;inhba;id2;ephx1;egr1;cyp1a1;csrp1;cebpd;ccnd1;asns;aldh1a1 ZFP354A_10203;TSKU_10094;ORM1_9400;NREP_9364;MGP_33209;LTBP1_33264;INHBA_33300;ID2_8861;EPHX1_8567;EGR1_8533;CYP1A1_8415;CSRP1_8396;CEBPD_8283;CCND1_8224;ASNS_8091;ALDH1A1_8022 165.954933125 81.80369999999999 2.99674 263.372307216272 184.2017521594262 285.76967020378464 94.745974625 34.8379 0.998544 145.98809299052485 103.57441124581857 156.3518872455991 538.9191125 175.862 6.6682 1236.3466600245024 637.3786693957907 1374.808157478236 3.26713;6.12626;56.9823;112.624;75.1005;998.777;130.168;2.99674;24.8784;8.26335;100.909;373.299;5.66035;512.733;154.987;88.5069 1.71987;1.46625;16.0812;79.4619;13.9312;507.146;89.164;0.998544;15.4867;1.51678;73.3629;263.875;2.15795;330.024;53.5946;65.9487 6.6682;41.3339;262.985;192.339;346.231;5065.92;231.33;10.914;41.3795;45.9052;159.385;603.145;16.35;1002.56;462.615;133.645 6 10 6 24614;25587;25315;24296;25612;24188 ORM1_9400;ID2_8861;EPHX1_8567;CYP1A1_8415;ASNS_8091;ALDH1A1_8022 71.54339 72.7446 55.13841788070273 37.578774 34.8379 30.430845225367893 178.48725 146.515 165.60404623128932 56.9823;2.99674;24.8784;100.909;154.987;88.5069 16.0812;0.998544;15.4867;73.3629;53.5946;65.9487 262.985;10.914;41.3795;159.385;462.615;133.645 10 24522;308843;338475;25333;59107;29200;24330;29276;25695;58919 ZFP354A_10203;TSKU_10094;NREP_9364;MGP_33209;LTBP1_33264;INHBA_33300;EGR1_8533;CSRP1_8396;CEBPD_8283;CCND1_8224 222.60185899999996 93.86224999999999 323.12766285720926 129.04629500000001 46.69655 177.53998453476146 755.17823 211.8345 1547.18474195392 3.26713;6.12626;112.624;75.1005;998.777;130.168;8.26335;373.299;5.66035;512.733 1.71987;1.46625;79.4619;13.9312;507.146;89.164;1.51678;263.875;2.15795;330.024 6.6682;41.3339;192.339;346.231;5065.92;231.33;45.9052;603.145;16.35;1002.56 0 Exp 2,3(0.19);Exp 4,5(0.32);Hill,4(0.25);Poly 2,4(0.25) 2.244760331554976 39.757140159606934 1.555469274520874 6.495501518249512 1.4079761323006017 1.9419646859169006 36.90250258902671 295.0073636609733 23.211809059642817 166.28014019035714 -66.8907509120063 1144.7289759120063 DOWN 0.375 0.625 0.0 GO:0048878 5 chemical homeostasis 274 291 19 17 7 12 4 4 48 287 2208 0.27426 0.86214 0.51131 1.37 24539;24424;117517;114628 lpl;gstm2;c7;abcg5 LPL_32544;GSTM2_8759;C7_8179;ABCG5_7947 286.882145 187.40545 3.28268 362.0888738225227 484.1767056778862 325.91818602941146 180.99873424999998 139.48793 0.808077 216.9431382236131 304.43741811931784 179.57319953835338 691.690425 285.24215 13.1174 1022.0531051652397 1182.3085002428986 1053.7068721564663 769.435;3.28268;13.8429;360.968 444.211;0.808077;5.32886;273.647 2183.16;13.1174;41.8963;528.588 1 3 1 24424 GSTM2_8759 3.28268 3.28268 0.808077 0.808077 13.1174 13.1174 3.28268 0.808077 13.1174 3 24539;117517;114628 LPL_32544;C7_8179;ABCG5_7947 381.41529999999995 360.968 378.2108201169951 241.06228666666667 273.647 221.24806408194067 917.8814333333333 528.588 1122.4591712671615 769.435;13.8429;360.968 444.211;5.32886;273.647 2183.16;41.8963;528.588 0 Exp 2,1(0.25);Hill,2(0.5);Linear,1(0.25) 1.976873010137699 8.00949740409851 1.6902254819869995 2.4614932537078857 0.37348277822138365 1.9288893342018127 -67.96495134607227 641.7292413460723 -31.605541209140796 393.6030097091408 -309.92161806193496 1693.302468061935 DOWN 0.25 0.75 0.0 GO:0046883 5 regulation of hormone secretion 83 89 6 5 3 4 2 2 50 87 2408 0.72759 0.54893 0.70326 2.25 29200;24484 inhba;igfbp3 INHBA_33300;IGFBP3_8881 87.53565 87.53565 44.9033 60.291247565836635 65.27146983322433 51.41640882099512 54.01975 54.01975 18.8755 49.70147498943065 35.66613088620013 42.385444989714586 177.0475 177.0475 122.765 76.7670476995175 148.69918328973185 65.46698016472632 130.168;44.9033 89.164;18.8755 231.33;122.765 0 2 0 2 29200;24484 INHBA_33300;IGFBP3_8881 87.53565 87.53565 60.291247565836635 54.01975 54.01975 49.70147498943065 177.0475 177.0475 76.7670476995175 130.168;44.9033 89.164;18.8755 231.33;122.765 0 Exp 4,1(0.5);Poly 2,1(0.5) 1.645255812639178 3.290566921234131 1.6357452869415283 1.6548216342926025 0.013489014572214613 1.6452834606170654 3.9762440000000083 171.095056 -14.862979999999979 122.90247999999998 70.65380000000003 283.4412 DOWN 0.0 1.0 0.0 GO:0006807 3 nitrogen compound metabolic process 1028 1128 53 49 23 37 17 17 35 1111 1384 0.058098 0.96869 0.092499 1.51 246273;266730;83619;307126;29200;24484;24424;300850;116686;297417;24330;24296;58919;25612;64392;24763;296925 trib3;slc17a3;nfe2l2;mcm10;inhba;igfbp3;gstm2;gsta4;gsr;gfpt1;egr1;cyp1a1;ccnd1;asns;aldh1l1;acsm3;aass TRIB3_10079;SLC17A3_9840;NFE2L2_9301;MCM10_32579;INHBA_33300;IGFBP3_8881;GSTM2_8759;GSTA4_8757;GSR_8755;GFPT1_8705;EGR1_8533;CYP1A1_8415;CCND1_8224;ASNS_8091;ALDH1L1_32662;ACSM3_7976;AASS_7936 181.49223117647057 100.909 3.28268 253.9671116977977 149.4527609719089 182.92195447966 110.82109805882352 57.2867 0.808077 152.7803812834233 94.21690444655896 118.02252055314831 553.1167705882352 159.385 13.1174 1015.2852924628589 368.8712225432404 564.4648875848444 16.8949;58.7587;6.6423;213.608;130.168;44.9033;3.28268;105.355;74.6342;981.5;8.26335;100.909;512.733;154.987;184.03;460.125;28.5735 6.46469;46.6655;3.4063;123.177;89.164;18.8755;0.808077;75.6422;57.2867;554.87;1.51678;73.3629;330.024;53.5946;111.154;331.8;6.14642 58.9909;78.8953;13.4683;668.095;231.33;122.765;13.1174;172.041;106.529;4240.48;45.9052;159.385;1002.56;462.615;1150.07;748.659;128.079 10 7 10 246273;266730;83619;24424;300850;116686;297417;24296;25612;64392 TRIB3_10079;SLC17A3_9840;NFE2L2_9301;GSTM2_8759;GSTA4_8757;GSR_8755;GFPT1_8705;CYP1A1_8415;ASNS_8091;ALDH1L1_32662 168.699378 87.7716 291.9819142834675 98.3254967 55.440650000000005 164.33252780108756 645.55919 132.957 1309.2527793987422 16.8949;58.7587;6.6423;3.28268;105.355;74.6342;981.5;100.909;154.987;184.03 6.46469;46.6655;3.4063;0.808077;75.6422;57.2867;554.87;73.3629;53.5946;111.154 58.9909;78.8953;13.4683;13.1174;172.041;106.529;4240.48;159.385;462.615;1150.07 7 307126;29200;24484;24330;58919;24763;296925 MCM10_32579;INHBA_33300;IGFBP3_8881;EGR1_8533;CCND1_8224;ACSM3_7976;AASS_7936 199.76773571428572 130.168 208.4599191617234 128.67195714285714 89.164 145.27613277067798 421.0561714285714 231.33 378.1635484311945 213.608;130.168;44.9033;8.26335;512.733;460.125;28.5735 123.177;89.164;18.8755;1.51678;330.024;331.8;6.14642 668.095;231.33;122.765;45.9052;1002.56;748.659;128.079 0 Exp 2,1(0.06);Exp 4,4(0.24);Hill,3(0.18);Linear,2(0.12);Poly 2,7(0.42) 1.9308034661394078 34.64758551120758 1.5232417583465576 5.289852619171143 0.8895574153185881 1.7613576650619507 60.76392971484738 302.22053263809374 38.193914933809424 183.44828118383765 70.48077871279094 1035.7527624636796 CONFLICT 0.5882352941176471 0.4117647058823529 0.0 GO:1903530 5 regulation of secretion by cell 205 222 9 8 5 7 4 4 48 218 2277 0.52049 0.6774 1.0 1.8 24614;24539;29200;24484 orm1;lpl;inhba;igfbp3 ORM1_9400;LPL_32544;INHBA_33300;IGFBP3_8881 250.37214999999998 93.57515000000001 44.9033 348.0863697085777 270.4821448765107 373.6531091547158 142.082925 54.01975 16.0812 204.23702782508002 150.24517589989486 220.86521462640326 700.06 247.15750000000003 122.765 990.5549783749174 783.5140245664738 1047.4250703575897 56.9823;769.435;130.168;44.9033 16.0812;444.211;89.164;18.8755 262.985;2183.16;231.33;122.765 1 3 1 24614 ORM1_9400 56.9823 56.9823 16.0812 16.0812 262.985 262.985 56.9823 16.0812 262.985 3 24539;29200;24484 LPL_32544;INHBA_33300;IGFBP3_8881 314.83543333333336 130.168 395.9963279838126 184.0835 89.164 228.0018760893208 845.7516666666667 231.33 1159.5009173598494 769.435;130.168;44.9033 444.211;89.164;18.8755 2183.16;231.33;122.765 0 Exp 2,1(0.25);Exp 4,2(0.5);Poly 2,1(0.25) 1.640925630609619 6.565481543540955 1.5846891403198242 1.6902254819869995 0.044015761706469966 1.6452834606170654 -90.7524923144062 591.4967923144061 -58.0693622685784 342.2352122685784 -270.683878807419 1670.8038788074189 DOWN 0.25 0.75 0.0 GO:0097305 5 response to alcohol 168 183 18 17 11 13 8 8 44 175 2320 0.98966 0.029772 0.029772 4.37 286954;24314;29200;116686;24330;58919;54232;24188 ugt2b1;nqo1;inhba;gsr;egr1;ccnd1;car3;aldh1a1 UGT2B10_33303,UGT2B1_33224;NQO1_33055;INHBA_33300;GSR_8755;EGR1_8533;CCND1_8224;CAR3_8196;ALDH1A1_8022 114.89046875 64.9221 8.26335 165.61223727006092 139.80450048763782 190.31710600335447 74.5444475 40.9739 1.51678 107.60414404882792 92.14815799630162 122.50446914935412 215.96304375 106.6215 37.0434 323.74808932730116 262.42040523046364 374.3558648504553 25.4966;24.1117;130.168;74.6342;8.26335;512.733;55.21;88.5069 11.3392;16.4151;89.164;57.2867;1.51678;330.024;24.6611;65.9487 63.97775;37.0434;231.33;106.529;45.9052;1002.56;106.714;133.645 5 4 4 286954;24314;116686;24188 UGT2B10_33303,UGT2B1_33224;NQO1_33055;GSR_8755;ALDH1A1_8022 53.18735 50.065400000000004 33.264641115404615 37.747425 36.8509 27.86609419292856 85.2987875 85.253375 43.09387910419869 25.4966;24.1117;74.6342;88.5069 11.3392;16.4151;57.2867;65.9487 63.97775;37.0434;106.529;133.645 4 29200;24330;58919;54232 INHBA_33300;EGR1_8533;CCND1_8224;CAR3_8196 176.59358749999998 92.68900000000001 229.64761700029447 111.34147 56.91255 150.4314220054383 346.6273 169.022 444.04704978259525 130.168;8.26335;512.733;55.21 89.164;1.51678;330.024;24.6611 231.33;45.9052;1002.56;106.714 0 Exp 2,1(0.12);Exp 4,3(0.34);Exp 5,1(0.12);Hill,1(0.12);Poly 2,3(0.34) 2.4164997115007796 24.171031713485718 1.555469274520874 5.289852619171143 1.4144561483148343 1.9608341455459595 0.12704344928717148 229.65389405071284 -0.02142004188627311 149.11031504188628 -8.382936222332233 440.3090237223323 CONFLICT 0.5 0.5 0.0 GO:0140352 4 export from cell 85 90 3 3 2 2 2 2 50 88 2407 0.72197 0.55509 0.70616 2.22 266730;29200 slc17a3;inhba SLC17A3_9840;INHBA_33300 94.46335 94.46335 58.7587 50.49400026978452 80.63748521547656 46.55464519427843 67.91475 67.91475 46.6655 30.050977540256522 59.68643079584775 27.70651145983845 155.11265 155.11265 78.8953 107.78761005813705 125.59910553633219 99.3784195307372 58.7587;130.168 46.6655;89.164 78.8953;231.33 1 1 1 266730 SLC17A3_9840 58.7587 58.7587 46.6655 46.6655 78.8953 78.8953 58.7587 46.6655 78.8953 1 29200 INHBA_33300 130.168 130.168 89.164 89.164 231.33 231.33 130.168 89.164 231.33 0 Poly 2,2(1) 1.7136782965506507 3.4310696125030518 1.6357452869415283 1.7953243255615234 0.1128394203434285 1.7155348062515259 24.482236 164.44446399999998 26.266220000000004 109.56327999999999 5.726644000000022 304.49865600000004 CONFLICT 0.5 0.5 0.0 GO:0007584 4 response to nutrient 144 154 13 12 10 12 10 10 42 144 2351 0.99981 8.4918E-4 8.4918E-4 6.49 24522;24614;24314;25333;59107;24539;116686;24296;58919;114628 zfp354a;orm1;nqo1;mgp;ltbp1;lpl;gsr;cyp1a1;ccnd1;abcg5 ZFP354A_10203;ORM1_9400;NQO1_33055;MGP_33209;LTBP1_33264;LPL_32544;GSR_8755;CYP1A1_8415;CCND1_8224;ABCG5_7947 297.691783 88.00475 3.26713 353.05126642667574 303.93835073499343 352.05037386318816 173.382497 65.3248 1.71987 196.38201836767507 176.11328221913502 196.88104747125738 969.9069599999999 304.608 6.6682 1582.3426882950196 987.3731091035387 1557.0933639917012 6.5 436.8505 3.26713;56.9823;24.1117;75.1005;998.777;769.435;74.6342;100.909;512.733;360.968 1.71987;16.0812;16.4151;13.9312;507.146;444.211;57.2867;73.3629;330.024;273.647 6.6682;262.985;37.0434;346.231;5065.92;2183.16;106.529;159.385;1002.56;528.588 4 6 4 24614;24314;116686;24296 ORM1_9400;NQO1_33055;GSR_8755;CYP1A1_8415 64.1593 65.80825 32.22619832196575 40.786474999999996 36.8509 29.08490687078954 141.4856 132.957 95.24114962402892 56.9823;24.1117;74.6342;100.909 16.0812;16.4151;57.2867;73.3629 262.985;37.0434;106.529;159.385 6 24522;25333;59107;24539;58919;114628 ZFP354A_10203;MGP_33209;LTBP1_33264;LPL_32544;CCND1_8224;ABCG5_7947 453.380105 436.8505 388.6150750670438 261.77984499999997 301.8355 213.23410225332762 1522.1878666666664 765.574 1893.7713600660952 3.26713;75.1005;998.777;769.435;512.733;360.968 1.71987;13.9312;507.146;444.211;330.024;273.647 6.6682;346.231;5065.92;2183.16;1002.56;528.588 0 Exp 2,3(0.3);Exp 4,3(0.3);Hill,1(0.1);Linear,1(0.1);Poly 2,2(0.2) 2.2580541871350777 25.78028094768524 1.555469274520874 6.495501518249512 1.6729859452161635 1.933514654636383 78.86834098781466 516.5152250121853 51.66366096959645 295.1013330304035 -10.839199049519038 1950.6531190495189 DOWN 0.4 0.6 0.0 GO:0006355 7 regulation of transcription, DNA-templated 466 499 27 23 13 18 12 12 40 487 2008 0.79622 0.31213 0.48415 2.4 24522;246273;360918;316351;83619;29200;494344;25587;24330;289185;25695;58919 zfp354a;trib3;pf4;npas2;nfe2l2;inhba;ier2;id2;egr1;creg1;cebpd;ccnd1 ZFP354A_10203;TRIB3_10079;PF4_32963;NPAS2_9350;NFE2L2_9301;INHBA_33300;IER2_32643;ID2_8861;EGR1_8533;CREG1_8380;CEBPD_8283;CCND1_8224 136.5480308333333 55.60825 2.99674 193.3490817315426 143.84820335937647 201.82826698257296 87.34706116666666 31.594794999999998 0.998544 130.38426352699753 89.85286296721593 135.0723269918971 271.63988333333333 103.20595 6.6682 362.3395349723562 286.1395640510017 381.19210847948847 3.26713;16.8949;179.631;134.458;6.6423;130.168;543.54;2.99674;8.26335;94.3216;5.66035;512.733 1.71987;6.46469;110.795;56.7249;3.4063;89.164;375.947;0.998544;1.51678;69.2457;2.15795;330.024 6.6682;58.9909;426.677;320.448;13.4683;231.33;978.946;10.914;45.9052;147.421;16.35;1002.56 5 7 5 246273;360918;83619;25587;289185 TRIB3_10079;PF4_32963;NFE2L2_9301;ID2_8861;CREG1_8380 60.097308 16.8949 76.55711346643967 38.1820468 6.46469 49.58716489906709 131.49424 58.9909 174.00644714191773 16.8949;179.631;6.6423;2.99674;94.3216 6.46469;110.795;3.4063;0.998544;69.2457 58.9909;426.677;13.4683;10.914;147.421 7 24522;316351;29200;494344;24330;25695;58919 ZFP354A_10203;NPAS2_9350;INHBA_33300;IER2_32643;EGR1_8533;CEBPD_8283;CCND1_8224 191.15569 130.168 237.234425128096 122.46492857142857 56.7249 161.4756043357438 371.74391428571425 231.33 438.6962928646326 3.26713;134.458;130.168;543.54;8.26335;5.66035;512.733 1.71987;56.7249;89.164;375.947;1.51678;2.15795;330.024 6.6682;320.448;231.33;978.946;45.9052;16.35;1002.56 0 Exp 2,1(0.09);Exp 4,4(0.34);Hill,3(0.25);Linear,1(0.09);Poly 2,3(0.25) 2.147989908066215 29.494117379188538 1.5423688888549805 6.495501518249512 1.6390943510217022 1.8453741073608398 27.150489335765712 245.94557233090092 13.57521931417159 161.11890301916173 66.62699184008633 476.6527748265803 CONFLICT 0.4166666666666667 0.5833333333333334 0.0 GO:0007050 6 cell cycle arrest 22 23 4 4 3 2 2 2 50 21 2474 0.98934 0.078753 0.078753 8.7 363140;29200 rassf1;inhba RASSF1_32475;INHBA_33300 443.3745 443.3745 130.168 442.9408801234087 611.5545531257428 373.6677170237544 263.332 263.332 89.164 246.3107477313972 356.8536334680295 207.78929855732002 585.7585 585.7585 231.33 501.23759159155236 776.0732091751843 422.8471900907347 0.5 443.3745 756.581;130.168 437.5;89.164 940.187;231.33 1 1 1 363140 RASSF1_32475 756.581 756.581 437.5 437.5 940.187 940.187 756.581 437.5 940.187 1 29200 INHBA_33300 130.168 130.168 89.164 89.164 231.33 231.33 130.168 89.164 231.33 0 Poly 2,2(1) 1.8947169303047349 3.8304343223571777 1.6357452869415283 2.1946890354156494 0.395232914847879 1.9152171611785889 -170.51023999999995 1057.2592399999999 -78.03728000000001 604.70128 -108.92135999999994 1280.43836 CONFLICT 0.5 0.5 0.0 GO:0048584 5 positive regulation of response to stimulus 502 537 15 14 10 11 8 8 44 529 1966 0.2013 0.88629 0.39085 1.49 316351;83619;24539;29200;24484;24424;289388;117517 npas2;nfe2l2;lpl;inhba;igfbp3;gstm2;g0s2;c7 NPAS2_9350;NFE2L2_9301;LPL_32544;INHBA_33300;IGFBP3_8881;GSTM2_8759;G0S2_32729;C7_8179 138.2728775 29.3731 3.28268 260.8701123606037 237.77603128195506 323.8558471138351 77.44904712499999 12.102179999999999 0.808077 151.6116262632498 131.76165010614181 189.89594020153672 367.5634 82.33064999999999 13.1174 742.4813978359226 649.1854233426228 929.7322161089272 134.458;6.6423;769.435;130.168;44.9033;3.28268;3.45084;13.8429 56.7249;3.4063;444.211;89.164;18.8755;0.808077;1.07374;5.32886 320.448;13.4683;2183.16;231.33;122.765;13.1174;14.3222;41.8963 3 5 3 83619;24424;289388 NFE2L2_9301;GSTM2_8759;G0S2_32729 4.458606666666667 3.45084 1.8930020805412038 1.7627056666666665 1.07374 1.4295789438909392 13.635966666666667 13.4683 0.6196530023596877 6.6423;3.28268;3.45084 3.4063;0.808077;1.07374 13.4683;13.1174;14.3222 5 316351;24539;29200;24484;117517 NPAS2_9350;LPL_32544;INHBA_33300;IGFBP3_8881;C7_8179 218.56144 130.168 312.41610800738647 122.860852 56.7249 182.62124888367325 579.91986 231.33 902.4521317320092 134.458;769.435;130.168;44.9033;13.8429 56.7249;444.211;89.164;18.8755;5.32886 320.448;2183.16;231.33;122.765;41.8963 0 Exp 2,1(0.13);Exp 4,3(0.38);Hill,3(0.38);Poly 2,1(0.13) 1.8124544215115548 14.659995198249817 1.5423688888549805 2.4614932537078857 0.30497620260621655 1.6980669498443604 -42.50088744989782 319.04664244989783 -27.612449731715103 182.5105439817151 -146.94995868835474 882.0767586883547 DOWN 0.375 0.625 0.0 GO:0042752 4 regulation of circadian rhythm 33 35 6 4 3 4 2 2 50 33 2462 0.96682 0.15908 0.15908 5.71 316351;25587 npas2;id2 NPAS2_9350;ID2_8861 68.72737 68.72737 2.99674 92.95714840932784 108.71291177971926 73.7790236961594 28.861722 28.861722 0.998544 39.40448421841564 45.811571226072445 31.274887672798922 165.68099999999998 165.68099999999998 10.914 218.8735904077968 259.82953234514576 173.71746110425997 0.5 68.72737 134.458;2.99674 56.7249;0.998544 320.448;10.914 1 1 1 25587 ID2_8861 2.99674 2.99674 0.998544 0.998544 10.914 10.914 2.99674 0.998544 10.914 1 316351 NPAS2_9350 134.458 134.458 56.7249 56.7249 320.448 320.448 134.458 56.7249 320.448 0 Hill,2(1) 1.9327876143478822 3.8665966987609863 1.8888624906539917 1.9777342081069946 0.06284179406671322 1.9332983493804932 -60.10466480000001 197.55940479999998 -25.75010687999999 83.47355087999999 -137.66231999999997 469.02431999999993 CONFLICT 0.5 0.5 0.0 GO:0044092 4 negative regulation of molecular function 276 297 16 15 8 10 5 5 47 292 2203 0.42331 0.74284 0.82757 1.68 246273;299270;24314;25587;24424 trib3;serpina6;nqo1;id2;gstm2 TRIB3_10079;SERPINA6_32325;NQO1_33055;ID2_8861;GSTM2_8759 12.626684000000001 15.8474 2.99674 9.226896879378245 15.077791629502572 9.596329391722813 6.487902199999999 6.46469 0.808077 6.374637013002012 8.391110893048129 7.128209310572864 32.18038 37.0434 10.914 20.205397118393876 34.85896962970437 19.67433277250097 16.8949;15.8474;24.1117;2.99674;3.28268 6.46469;7.7531;16.4151;0.998544;0.808077 58.9909;40.8362;37.0434;10.914;13.1174 4 1 4 246273;24314;25587;24424 TRIB3_10079;NQO1_33055;ID2_8861;GSTM2_8759 11.821505 10.08879 10.44950141792899 6.17160275 3.731617 7.315351013422271 30.016424999999998 25.080399999999997 22.652286610167344 16.8949;24.1117;2.99674;3.28268 6.46469;16.4151;0.998544;0.808077 58.9909;37.0434;10.914;13.1174 1 299270 SERPINA6_32325 15.8474 15.8474 7.7531 7.7531 40.8362 40.8362 15.8474 7.7531 40.8362 0 Exp 4,3(0.6);Hill,2(0.4) 2.313424941633113 12.539740800857544 1.7059084177017212 4.773829460144043 1.2843753759809329 1.9777342081069946 4.538952291681191 20.71441570831881 0.900286496360188 12.075517903639813 14.469568544110018 49.89119145588998 UP 0.8 0.2 0.0 GO:0065007 2 biological regulation 1742 1890 86 80 44 63 35 35 17 1855 640 0.16111 0.90228 0.26295 1.85 24522;308843;246273;170698;299270;363140;360918;24614;338475;24314;316351;83619;25333;59107;24539;29200;24484;494344;25587;24424;116686;297417;289388;246248;24330;499353;24296;289185;25695;58919;117517;25612;64392;24188;114628 zfp354a;tsku;trib3;slco1a2;serpina6;rassf1;pf4;orm1;nrep;nqo1;npas2;nfe2l2;mgp;ltbp1;lpl;inhba;igfbp3;ier2;id2;gstm2;gsr;gfpt1;g0s2;fmo5;egr1;cyp2c24;cyp1a1;creg1;cebpd;ccnd1;c7;asns;aldh1l1;aldh1a1;abcg5 ZFP354A_10203;TSKU_10094;TRIB3_10079;SLCO1A2_9886;SERPINA6_32325;RASSF1_32475;PF4_32963;ORM1_9400;NREP_9364;NQO1_33055;NPAS2_9350;NFE2L2_9301;MGP_33209;LTBP1_33264;LPL_32544;INHBA_33300;IGFBP3_8881;IER2_32643;ID2_8861;GSTM2_8759;GSR_8755;GFPT1_8705;G0S2_32729;FMO5_33281;EGR1_8533;CYP2C24_32875;CYP1A1_8415;CREG1_8380;CEBPD_8283;CCND1_8224;C7_8179;ASNS_8091;ALDH1L1_32662;ALDH1A1_8022;ABCG5_7947 219.93151857142854 88.5069 2.99674 299.0303248475869 261.0040912906128 312.49779881452594 130.91961317142858 56.7249 0.808077 175.58630450117718 154.66138320466317 183.26979085128798 628.2406857142856 159.385 6.6682 1133.0482753323913 691.5819424596457 1126.253935204507 3.26713;6.12626;16.8949;440.994;15.8474;756.581;179.631;56.9823;112.624;24.1117;134.458;6.6423;75.1005;998.777;769.435;130.168;44.9033;543.54;2.99674;3.28268;74.6342;981.5;3.45084;57.4978;8.26335;733.935;100.909;94.3216;5.66035;512.733;13.8429;154.987;184.03;88.5069;360.968 1.71987;1.46625;6.46469;299.351;7.7531;437.5;110.795;16.0812;79.4619;16.4151;56.7249;3.4063;13.9312;507.146;444.211;89.164;18.8755;375.947;0.998544;0.808077;57.2867;554.87;1.07374;31.5489;1.51678;463.206;73.3629;69.2457;2.15795;330.024;5.32886;53.5946;111.154;65.9487;273.647 6.6682;41.3339;58.9909;772.521;40.8362;940.187;426.677;262.985;192.339;37.0434;320.448;13.4683;346.231;5065.92;2183.16;231.33;122.765;978.946;10.914;13.1174;106.529;4240.48;14.3222;109.026;45.9052;1763.75;159.385;147.421;16.35;1002.56;41.8963;462.615;1150.07;133.645;528.588 17 18 17 246273;363140;360918;24614;24314;83619;25587;24424;116686;297417;289388;246248;24296;289185;25612;64392;24188 TRIB3_10079;RASSF1_32475;PF4_32963;ORM1_9400;NQO1_33055;NFE2L2_9301;ID2_8861;GSTM2_8759;GSR_8755;GFPT1_8705;G0S2_32729;FMO5_33281;CYP1A1_8415;CREG1_8380;ASNS_8091;ALDH1L1_32662;ALDH1A1_8022 163.93882117647058 74.6342 274.88633310800276 94.73847947058823 53.5946 156.8431364449341 487.46330588235287 133.645 1021.8770910385048 16.8949;756.581;179.631;56.9823;24.1117;6.6423;2.99674;3.28268;74.6342;981.5;3.45084;57.4978;100.909;94.3216;154.987;184.03;88.5069 6.46469;437.5;110.795;16.0812;16.4151;3.4063;0.998544;0.808077;57.2867;554.87;1.07374;31.5489;73.3629;69.2457;53.5946;111.154;65.9487 58.9909;940.187;426.677;262.985;37.0434;13.4683;10.914;13.1174;106.529;4240.48;14.3222;109.026;159.385;147.421;462.615;1150.07;133.645 18 24522;308843;170698;299270;338475;316351;25333;59107;24539;29200;24484;494344;24330;499353;25695;58919;117517;114628 ZFP354A_10203;TSKU_10094;SLCO1A2_9886;SERPINA6_32325;NREP_9364;NPAS2_9350;MGP_33209;LTBP1_33264;LPL_32544;INHBA_33300;IGFBP3_8881;IER2_32643;EGR1_8533;CYP2C24_32875;CEBPD_8283;CCND1_8224;C7_8179;ABCG5_7947 272.8135105555555 121.396 318.78588332056574 165.0906838888889 68.0934 189.63900957985027 761.1971 275.889 1243.4845922480774 3.26713;6.12626;440.994;15.8474;112.624;134.458;75.1005;998.777;769.435;130.168;44.9033;543.54;8.26335;733.935;5.66035;512.733;13.8429;360.968 1.71987;1.46625;299.351;7.7531;79.4619;56.7249;13.9312;507.146;444.211;89.164;18.8755;375.947;1.51678;463.206;2.15795;330.024;5.32886;273.647 6.6682;41.3339;772.521;40.8362;192.339;320.448;346.231;5065.92;2183.16;231.33;122.765;978.946;45.9052;1763.75;16.35;1002.56;41.8963;528.588 0 Exp 2,4(0.12);Exp 4,10(0.29);Exp 5,1(0.03);Hill,7(0.2);Linear,4(0.12);Poly 2,9(0.26) 2.0470376332781925 77.10135972499847 1.5232417583465576 6.495501518249512 1.098581886733046 1.8309566974639893 120.86263204701552 319.00040509584164 72.74778834150769 189.09143800134947 252.86126199597464 1003.6201094325972 CONFLICT 0.4857142857142857 0.5142857142857142 0.0 GO:0032526 5 response to retinoic acid 42 45 5 5 3 4 2 2 50 43 2452 0.93755 0.23371 0.23371 4.44 24614;24188 orm1;aldh1a1 ORM1_9400;ALDH1A1_8022 72.7446 72.7446 56.9823 22.291258434193438 69.79638731199383 21.89786031722183 41.01495 41.01495 16.0812 35.26164741082017 36.3512906286155 34.6393467123789 198.315 198.315 133.645 91.45719107866819 210.411008484381 89.84314641357784 56.9823;88.5069 16.0812;65.9487 262.985;133.645 2 0 2 24614;24188 ORM1_9400;ALDH1A1_8022 72.7446 72.7446 22.291258434193438 41.01495 41.01495 35.26164741082017 198.315 198.315 91.45719107866819 56.9823;88.5069 16.0812;65.9487 262.985;133.645 0 0 Exp 4,1(0.5);Poly 2,1(0.5) 2.1061474359164847 4.383886098861694 1.5846891403198242 2.79919695854187 0.8587867140688874 2.191943049430847 41.85049200000001 103.63870800000001 -7.8552000000000035 89.8851 71.5618 325.0682 UP 1.0 0.0 0.0 GO:0043434 5 response to peptide hormone 194 204 21 19 11 12 7 7 45 197 2298 0.94816 0.11758 0.18757 3.43 286954;246273;24614;83619;24484;297417;24330 ugt2b1;trib3;orm1;nfe2l2;igfbp3;gfpt1;egr1 UGT2B10_33303,UGT2B1_33224;TRIB3_10079;ORM1_9400;NFE2L2_9301;IGFBP3_8881;GFPT1_8705;EGR1_8533 162.95467857142856 25.4966 6.6423 361.4263099964822 62.01916340288693 173.45931616017543 87.50766714285714 11.3392 1.51678 206.18629800372645 27.937583277142483 98.93665795117248 686.9388785714285 63.97775 13.4683 1569.106411670296 246.63079828182904 754.1736526926697 25.4966;16.8949;56.9823;6.6423;44.9033;981.5;8.26335 11.3392;6.46469;16.0812;3.4063;18.8755;554.87;1.51678 63.97775;58.9909;262.985;13.4683;122.765;4240.48;45.9052 6 2 5 286954;246273;24614;83619;297417 UGT2B10_33303,UGT2B1_33224;TRIB3_10079;ORM1_9400;NFE2L2_9301;GFPT1_8705 217.50322 25.4966 427.5016413326117 118.432278 11.3392 244.0237038103162 927.9803899999999 63.97775 1854.241636989702 25.4966;16.8949;56.9823;6.6423;981.5 11.3392;6.46469;16.0812;3.4063;554.87 63.97775;58.9909;262.985;13.4683;4240.48 2 24484;24330 IGFBP3_8881;EGR1_8533 26.583325000000002 26.583325000000002 25.90835710733604 10.19614 10.19614 12.274468624718544 84.3351 84.3351 54.348085780641796 44.9033;8.26335 18.8755;1.51678 122.765;45.9052 0 Exp 4,6(0.75);Hill,1(0.13);Linear,1(0.13) 1.955575642417321 17.265472531318665 1.5232417583465576 5.289852619171143 1.2874680973061565 1.6767478585243225 -104.79367881597173 430.7030359588289 -65.23727997187868 240.25261425759297 -475.4714182740029 1849.3491754168601 UP 0.7142857142857143 0.2857142857142857 0.0 GO:0009893 5 positive regulation of metabolic process 777 837 39 36 19 28 16 16 36 821 1674 0.43677 0.67734 0.88156 1.91 246273;363140;360918;24614;316351;83619;59107;24539;29200;24484;494344;25587;289388;24330;25695;58919 trib3;rassf1;pf4;orm1;npas2;nfe2l2;ltbp1;lpl;inhba;igfbp3;ier2;id2;g0s2;egr1;cebpd;ccnd1 TRIB3_10079;RASSF1_32475;PF4_32963;ORM1_9400;NPAS2_9350;NFE2L2_9301;LTBP1_33264;LPL_32544;INHBA_33300;IGFBP3_8881;IER2_32643;ID2_8861;G0S2_32729;EGR1_8533;CEBPD_8283;CCND1_8224 260.6948175 93.57515000000001 2.99674 337.2384710689085 342.87018307836547 369.62635726641014 150.13041275 37.8002 0.998544 193.16199057973745 192.9671674282903 210.3099147601321 730.9330375 247.15750000000003 10.914 1295.0619816829349 968.3457972137977 1447.2499507356413 16.8949;756.581;179.631;56.9823;134.458;6.6423;998.777;769.435;130.168;44.9033;543.54;2.99674;3.45084;8.26335;5.66035;512.733 6.46469;437.5;110.795;16.0812;56.7249;3.4063;507.146;444.211;89.164;18.8755;375.947;0.998544;1.07374;1.51678;2.15795;330.024 58.9909;940.187;426.677;262.985;320.448;13.4683;5065.92;2183.16;231.33;122.765;978.946;10.914;14.3222;45.9052;16.35;1002.56 7 9 7 246273;363140;360918;24614;83619;25587;289388 TRIB3_10079;RASSF1_32475;PF4_32963;ORM1_9400;NFE2L2_9301;ID2_8861;G0S2_32729 146.16844 16.8949 276.50287666185557 82.33135342857143 6.46469 161.52748466900366 246.79205714285717 58.9909 344.6755221552383 16.8949;756.581;179.631;56.9823;6.6423;2.99674;3.45084 6.46469;437.5;110.795;16.0812;3.4063;0.998544;1.07374 58.9909;940.187;426.677;262.985;13.4683;10.914;14.3222 9 316351;59107;24539;29200;24484;494344;24330;25695;58919 NPAS2_9350;LTBP1_33264;LPL_32544;INHBA_33300;IGFBP3_8881;IER2_32643;EGR1_8533;CEBPD_8283;CCND1_8224 349.7708888888889 134.458 368.10304166600616 202.86301444444445 89.164 207.94320636974686 1107.4871333333333 320.448 1640.4302578417528 134.458;998.777;769.435;130.168;44.9033;543.54;8.26335;5.66035;512.733 56.7249;507.146;444.211;89.164;18.8755;375.947;1.51678;2.15795;330.024 320.448;5065.92;2183.16;231.33;122.765;978.946;45.9052;16.35;1002.56 0 Exp 2,3(0.19);Exp 4,6(0.38);Hill,3(0.19);Linear,1(0.07);Poly 2,3(0.19) 1.8920334985473672 32.015398144721985 1.5423688888549805 5.289852619171143 0.9088407019702248 1.672523558139801 95.44796667623481 425.94166832376504 55.48103736592866 244.77978813407134 96.35266647536184 1365.5134085246382 CONFLICT 0.4375 0.5625 0.0 GO:0003166 9 bundle of His development 1 1 1 1 1 1 1 1 51 0 2495 1.0 0.020416 0.020416 100.0 25587 id2 ID2_8861 2.99674 2.99674 2.99674 2.99674 0.998544 0.998544 0.998544 0.9985439999999999 10.914 10.914 10.914 10.914 0.0 2.99674 0.0 2.99674 2.99674 0.998544 10.914 1 0 1 25587 ID2_8861 2.99674 2.99674 0.998544 0.998544 10.914 10.914 2.99674 0.998544 10.914 0 0 Hill,1(1) 1.9777342081069946 1.9777342081069946 1.9777342081069946 1.9777342081069946 0.0 1.9777342081069946 2.99674 2.99674 0.998544 0.998544 10.914 10.914 UP 1.0 0.0 0.0 GO:0045578 9 negative regulation of B cell differentiation 1 1 1 1 1 1 1 1 51 0 2495 1.0 0.020416 0.020416 100.0 25587 id2 ID2_8861 2.99674 2.99674 2.99674 2.99674 0.998544 0.998544 0.998544 0.9985439999999999 10.914 10.914 10.914 10.914 0.0 2.99674 0.0 2.99674 2.99674 0.998544 10.914 1 0 1 25587 ID2_8861 2.99674 2.99674 0.998544 0.998544 10.914 10.914 2.99674 0.998544 10.914 0 0 Hill,1(1) 1.9777342081069946 1.9777342081069946 1.9777342081069946 1.9777342081069946 0.0 1.9777342081069946 2.99674 2.99674 0.998544 0.998544 10.914 10.914 UP 1.0 0.0 0.0 GO:0019221 6 cytokine-mediated signaling pathway 83 85 3 3 2 3 2 2 50 83 2412 0.74993 0.52374 0.69183 2.35 360918;24330 pf4;egr1 PF4_32963;EGR1_8533 93.947175 93.947175 8.26335 121.17522739100286 36.95707211825108 90.48586674346771 56.15589 56.15589 1.51678 77.27137039799541 19.814275929115603 57.701289904385966 236.2911 236.2911 45.9052 269.2463218646079 109.66145866180855 201.0558372859191 179.631;8.26335 110.795;1.51678 426.677;45.9052 1 1 1 360918 PF4_32963 179.631 179.631 110.795 110.795 426.677 426.677 179.631 110.795 426.677 1 24330 EGR1_8533 8.26335 8.26335 1.51678 1.51678 45.9052 45.9052 8.26335 1.51678 45.9052 0 Hill,1(0.5);Poly 2,1(0.5) 3.1365622947229768 7.149644136428833 1.8597915172576904 5.289852619171143 2.4254194650472036 3.5748220682144165 -73.99312199999999 261.887472 -50.936765600000015 163.2485456 -136.865264 609.447464 CONFLICT 0.5 0.5 0.0 GO:0048513 4 animal organ development 418 452 24 23 14 20 12 12 40 440 2055 0.88257 0.19893 0.35701 2.65 24522;308843;24614;25333;29200;25587;25315;24330;24296;58919;25612;24188 zfp354a;tsku;orm1;mgp;inhba;id2;ephx1;egr1;cyp1a1;ccnd1;asns;aldh1a1 ZFP354A_10203;TSKU_10094;ORM1_9400;MGP_33209;INHBA_33300;ID2_8861;EPHX1_8567;EGR1_8533;CYP1A1_8415;CCND1_8224;ASNS_8091;ALDH1A1_8022 97.07654833333333 66.0414 2.99674 140.91296523315907 104.56936062787204 146.40433846009412 55.274562 15.78395 0.998544 92.1990864947329 59.684543348798165 97.34294539257975 228.74598333333333 146.515 6.6682 283.2841913650955 252.83371121273711 287.4718086712817 3.26713;6.12626;56.9823;75.1005;130.168;2.99674;24.8784;8.26335;100.909;512.733;154.987;88.5069 1.71987;1.46625;16.0812;13.9312;89.164;0.998544;15.4867;1.51678;73.3629;330.024;53.5946;65.9487 6.6682;41.3339;262.985;346.231;231.33;10.914;41.3795;45.9052;159.385;1002.56;462.615;133.645 6 6 6 24614;25587;25315;24296;25612;24188 ORM1_9400;ID2_8861;EPHX1_8567;CYP1A1_8415;ASNS_8091;ALDH1A1_8022 71.54339 72.7446 55.13841788070273 37.578774 34.8379 30.430845225367893 178.48725 146.515 165.60404623128932 56.9823;2.99674;24.8784;100.909;154.987;88.5069 16.0812;0.998544;15.4867;73.3629;53.5946;65.9487 262.985;10.914;41.3795;159.385;462.615;133.645 6 24522;308843;25333;29200;24330;58919 ZFP354A_10203;TSKU_10094;MGP_33209;INHBA_33300;EGR1_8533;CCND1_8224 122.60970666666667 41.681925 197.68488548858798 72.97035 7.825535 130.4756792618094 279.00471666666664 138.6176 378.23656087031253 3.26713;6.12626;75.1005;130.168;8.26335;512.733 1.71987;1.46625;13.9312;89.164;1.51678;330.024 6.6682;41.3339;346.231;231.33;45.9052;1002.56 0 Exp 2,1(0.09);Exp 4,4(0.34);Hill,4(0.34);Poly 2,3(0.25) 2.4573624198232595 32.899365305900574 1.555469274520874 6.495501518249512 1.5528564765210595 2.191907525062561 17.347532691854 176.80556397481269 3.108017941363812 107.4411060586362 68.46286327436601 389.0291033923006 CONFLICT 0.5 0.5 0.0 GO:0080135 5 regulation of cellular response to stress 165 174 7 6 4 3 2 2 50 172 2323 0.2985 0.88113 0.57878 1.15 316351;83619 npas2;nfe2l2 NPAS2_9350;NFE2L2_9301 70.55015 70.55015 6.6423 90.3793482121054 96.35750987061948 82.68244636113324 30.0656 30.0656 3.4063 37.70194362337305 40.83119685545368 34.491164110126675 166.95815 166.95815 13.4683 217.06742755661202 228.9406419072916 198.58149334711442 134.458;6.6423 56.7249;3.4063 320.448;13.4683 1 1 1 83619 NFE2L2_9301 6.6423 6.6423 3.4063 3.4063 13.4683 13.4683 6.6423 3.4063 13.4683 1 316351 NPAS2_9350 134.458 134.458 56.7249 56.7249 320.448 320.448 134.458 56.7249 320.448 0 Exp 4,1(0.5);Hill,1(0.5) 1.706845845678469 3.431231379508972 1.5423688888549805 1.8888624906539917 0.24500797546983216 1.715615689754486 -54.70923599999999 195.80953599999998 -22.18662799999999 82.31782799999999 -133.88195599999995 467.7982559999999 CONFLICT 0.5 0.5 0.0 GO:0006575 4 cellular modified amino acid metabolic process 61 71 10 10 4 10 4 4 48 67 2428 0.98628 0.054956 0.054956 5.63 24424;300850;116686;64392 gstm2;gsta4;gsr;aldh1l1 GSTM2_8759;GSTA4_8757;GSR_8755;ALDH1L1_32662 91.82547 89.9946 3.28268 74.87787603767174 97.74490111805171 58.87037486904718 61.22274425 66.46445 0.808077 46.066891466519635 67.51532235953191 33.44413342714662 360.43935 139.285 13.1174 530.444312028784 331.76245292954854 490.8910481787396 2.5 144.6925 3.28268;105.355;74.6342;184.03 0.808077;75.6422;57.2867;111.154 13.1174;172.041;106.529;1150.07 4 0 4 24424;300850;116686;64392 GSTM2_8759;GSTA4_8757;GSR_8755;ALDH1L1_32662 91.82547 89.9946 74.87787603767174 61.22274425 66.46445 46.066891466519635 360.43935 139.285 530.444312028784 3.28268;105.355;74.6342;184.03 0.808077;75.6422;57.2867;111.154 13.1174;172.041;106.529;1150.07 0 0 Hill,1(0.25);Poly 2,3(0.75) 1.8689816469438905 7.499080777168274 1.7059084177017212 2.0709805488586426 0.17056983743146925 1.861095905303955 18.445151483081716 165.2057885169183 16.07719061281076 106.36829788718924 -159.39607578820835 880.2747757882083 UP 1.0 0.0 0.0 GO:0048518 4 positive regulation of biological process 1152 1238 53 50 28 38 22 22 30 1216 1279 0.21858 0.85512 0.40159 1.78 246273;363140;360918;24614;24314;316351;83619;59107;24539;29200;24484;494344;25587;24424;289388;24330;24296;25695;58919;117517;25612;24188 trib3;rassf1;pf4;orm1;nqo1;npas2;nfe2l2;ltbp1;lpl;inhba;igfbp3;ier2;id2;gstm2;g0s2;egr1;cyp1a1;cebpd;ccnd1;c7;asns;aldh1a1 TRIB3_10079;RASSF1_32475;PF4_32963;ORM1_9400;NQO1_33055;NPAS2_9350;NFE2L2_9301;LTBP1_33264;LPL_32544;INHBA_33300;IGFBP3_8881;IER2_32643;ID2_8861;GSTM2_8759;G0S2_32729;EGR1_8533;CYP1A1_8415;CEBPD_8283;CCND1_8224;C7_8179;ASNS_8091;ALDH1A1_8022 207.12533000000002 72.7446 2.99674 300.1853708255121 282.6390147768 341.1393187779375 118.97931095454547 36.23505 0.808077 172.06977036440864 160.62544065740676 193.00171227261018 570.1195772727273 146.515 10.914 1130.0183353016184 780.368785404717 1307.600474189526 16.8949;756.581;179.631;56.9823;24.1117;134.458;6.6423;998.777;769.435;130.168;44.9033;543.54;2.99674;3.28268;3.45084;8.26335;100.909;5.66035;512.733;13.8429;154.987;88.5069 6.46469;437.5;110.795;16.0812;16.4151;56.7249;3.4063;507.146;444.211;89.164;18.8755;375.947;0.998544;0.808077;1.07374;1.51678;73.3629;2.15795;330.024;5.32886;53.5946;65.9487 58.9909;940.187;426.677;262.985;37.0434;320.448;13.4683;5065.92;2183.16;231.33;122.765;978.946;10.914;13.1174;14.3222;45.9052;159.385;16.35;1002.56;41.8963;462.615;133.645 12 10 12 246273;363140;360918;24614;24314;83619;25587;24424;289388;24296;25612;24188 TRIB3_10079;RASSF1_32475;PF4_32963;ORM1_9400;NQO1_33055;NFE2L2_9301;ID2_8861;GSTM2_8759;G0S2_32729;CYP1A1_8415;ASNS_8091;ALDH1A1_8022 116.24803000000001 40.547 210.7875921166818 65.53740425 16.24815 122.59614098420381 211.1125166666667 96.31795000000001 280.1219013119526 16.8949;756.581;179.631;56.9823;24.1117;6.6423;2.99674;3.28268;3.45084;100.909;154.987;88.5069 6.46469;437.5;110.795;16.0812;16.4151;3.4063;0.998544;0.808077;1.07374;73.3629;53.5946;65.9487 58.9909;940.187;426.677;262.985;37.0434;13.4683;10.914;13.1174;14.3222;159.385;462.615;133.645 10 316351;59107;24539;29200;24484;494344;24330;25695;58919;117517 NPAS2_9350;LTBP1_33264;LPL_32544;INHBA_33300;IGFBP3_8881;IER2_32643;EGR1_8533;CEBPD_8283;CCND1_8224;C7_8179 316.17809 132.313 362.9449983762713 183.109599 72.94445 205.7616702664416 1000.9280500000001 275.889 1582.8956197922598 134.458;998.777;769.435;130.168;44.9033;543.54;8.26335;5.66035;512.733;13.8429 56.7249;507.146;444.211;89.164;18.8755;375.947;1.51678;2.15795;330.024;5.32886 320.448;5065.92;2183.16;231.33;122.765;978.946;45.9052;16.35;1002.56;41.8963 0 Exp 2,3(0.14);Exp 4,8(0.37);Hill,5(0.23);Linear,1(0.05);Poly 2,5(0.23) 2.0547556865950876 48.29617428779602 1.5423688888549805 5.289852619171143 0.9902906549281997 1.874327003955841 81.68584724503148 332.5648127549686 47.07593027706433 190.8826916320266 97.91496885341974 1042.324185692035 CONFLICT 0.5454545454545454 0.45454545454545453 0.0 GO:0032922 6 circadian regulation of gene expression 22 23 7 5 5 5 4 4 48 19 2476 0.99993 0.0010272 0.0010272 17.39 316351;25587;297417;24330 npas2;id2;gfpt1;egr1 NPAS2_9350;ID2_8861;GFPT1_8705;EGR1_8533 281.8045225 71.360675 2.99674 470.40525491751544 132.02738153272526 262.80856581269165 153.527556 29.120839999999998 0.998544 268.8363114650287 63.83802348946135 149.45362428617878 1154.4368 183.17659999999998 10.914 2062.012500213491 441.82267018365576 1142.3969756090578 0.5 5.630045000000001 1.5 71.360675 134.458;2.99674;981.5;8.26335 56.7249;0.998544;554.87;1.51678 320.448;10.914;4240.48;45.9052 2 2 2 25587;297417 ID2_8861;GFPT1_8705 492.24837 492.24837 691.9062905591434 277.934272 277.934272 391.64626244326644 2125.6969999999997 2125.6969999999997 2990.7548000760607 2.99674;981.5 0.998544;554.87 10.914;4240.48 2 316351;24330 NPAS2_9350;EGR1_8533 71.360675 71.360675 89.23309276446294 29.120839999999998 29.120839999999998 39.038036028560654 183.17659999999998 183.17659999999998 194.1310756059421 134.458;8.26335 56.7249;1.51678 320.448;45.9052 0 Hill,3(0.75);Linear,1(0.25) 2.342314297151048 10.679691076278687 1.5232417583465576 5.289852619171143 1.757658472917123 1.9332983493804932 -179.19262731916513 742.8016723191652 -109.93202923572812 416.98714123572813 -866.3354502092211 3175.209050209221 CONFLICT 0.5 0.5 0.0 GO:0019439 5 aromatic compound catabolic process 57 68 8 8 6 5 4 4 48 64 2431 0.9885 0.048153 0.048153 5.88 286954;25315;24296;64392 ugt2b1;ephx1;cyp1a1;aldh1l1 UGT2B10_33303,UGT2B1_33224;EPHX1_8567;CYP1A1_8415;ALDH1L1_32662 83.82849999999999 63.2028 24.8784 75.74036557019427 88.72462737724875 59.75788349204607 52.8357 44.4248 11.3392 48.094689131545486 59.34436785608007 39.93784560955866 353.7030625 111.681375 41.3795 533.3687195404934 269.92977882456375 420.96652095542555 2.5 142.4695 25.4966;24.8784;100.909;184.03 11.3392;15.4867;73.3629;111.154 63.97775;41.3795;159.385;1150.07 5 0 4 286954;25315;24296;64392 UGT2B10_33303,UGT2B1_33224;EPHX1_8567;CYP1A1_8415;ALDH1L1_32662 83.82849999999999 63.2028 75.74036557019427 52.8357 44.4248 48.094689131545486 353.7030625 111.681375 533.3687195404934 25.4966;24.8784;100.909;184.03 11.3392;15.4867;73.3629;111.154 63.97775;41.3795;159.385;1150.07 0 0 Exp 4,3(0.6);Poly 2,2(0.4) 1.9128049525539892 9.705853939056396 1.6986740827560425 2.6370131969451904 0.39795313340732336 1.7613576650619507 9.60294174120962 158.05405825879035 5.702904651085412 99.96849534891459 -168.99828264968357 876.4044076496835 UP 1.0 0.0 0.0 GO:2000045 8 regulation of G1/S transition of mitotic cell cycle 38 40 4 4 3 3 3 3 49 37 2458 0.99179 0.04666 0.04666 7.5 25587;24296;58919 id2;cyp1a1;ccnd1 ID2_8861;CYP1A1_8415;CCND1_8224 205.54624666666666 100.909 2.99674 270.4985743625694 236.79314484720413 253.64583801641334 134.795148 73.3629 0.998544 172.90135480889705 156.82391919050713 159.82411301130185 390.953 159.385 10.914 534.8441373867718 443.2168733745123 511.8705352710858 1.0 100.909 2.99674;100.909;512.733 0.998544;73.3629;330.024 10.914;159.385;1002.56 2 1 2 25587;24296 ID2_8861;CYP1A1_8415 51.952870000000004 51.952870000000004 69.23442300730035 37.180721999999996 37.180721999999996 51.16932684379743 85.14949999999999 85.14949999999999 104.9848509095479 2.99674;100.909 0.998544;73.3629 10.914;159.385 1 58919 CCND1_8224 512.733 512.733 330.024 330.024 1002.56 1002.56 512.733 330.024 1002.56 0 Exp 2,1(0.34);Hill,1(0.34);Poly 2,1(0.34) 1.8032900035355235 5.439398646354675 1.555469274520874 1.9777342081069946 0.2259919461568684 1.9061951637268066 -100.55170579166668 511.644199125 -60.861153734648724 330.4514497346487 -214.2801171217019 996.1861171217018 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0044271 5 cellular nitrogen compound biosynthetic process 201 229 15 13 7 10 4 4 48 225 2270 0.4921 0.70164 1.0 1.75 297417;24330;25612;64392 gfpt1;egr1;asns;aldh1l1 GFPT1_8705;EGR1_8533;ASNS_8091;ALDH1L1_32662 332.1950875 169.5085 8.26335 439.6529841385104 170.3044867532129 304.1703518413654 180.28384499999999 82.3743 1.51678 253.70688554234678 88.25759944946161 174.47891789857948 1474.7675499999998 806.3425 45.9052 1899.1835311329646 772.089128638416 1338.562705851635 981.5;8.26335;154.987;184.03 554.87;1.51678;53.5946;111.154 4240.48;45.9052;462.615;1150.07 3 1 3 297417;25612;64392 GFPT1_8705;ASNS_8091;ALDH1L1_32662 440.17233333333337 184.03 469.02836373329626 239.87286666666668 111.154 274.30943592638835 1951.0549999999996 1150.07 2012.2745133865308 981.5;154.987;184.03 554.87;53.5946;111.154 4240.48;462.615;1150.07 1 24330 EGR1_8533 8.26335 8.26335 1.51678 1.51678 45.9052 45.9052 8.26335 1.51678 45.9052 0 Exp 4,1(0.25);Hill,1(0.25);Linear,1(0.25);Poly 2,1(0.25) 2.4727216727394565 11.20860493183136 1.5232417583465576 5.289852619171143 1.725856533790256 2.19775527715683 -98.66483695574021 763.0550119557402 -68.3489028314998 428.9165928314998 -386.43231051030557 3335.967410510305 UP 0.75 0.25 0.0 GO:0010827 6 regulation of glucose transmembrane transport 28 31 4 4 4 2 2 2 50 29 2466 0.97588 0.13074 0.13074 6.45 246273;83619 trib3;nfe2l2 TRIB3_10079;NFE2L2_9301 11.7686 11.7686 6.6423 7.249682984793195 10.786183541702346 7.115308790553769 4.9354949999999995 4.9354949999999995 3.4063 2.1626083085131285 4.642436393218016 2.1225239697190728 36.229600000000005 36.229600000000005 13.4683 32.18933915724272 31.867569737968832 31.59270389451097 0.5 11.7686 16.8949;6.6423 6.46469;3.4063 58.9909;13.4683 2 0 2 246273;83619 TRIB3_10079;NFE2L2_9301 11.7686 11.7686 7.249682984793195 4.9354949999999995 4.9354949999999995 2.1626083085131285 36.229600000000005 36.229600000000005 32.18933915724272 16.8949;6.6423 6.46469;3.4063 58.9909;13.4683 0 0 Exp 4,2(1) 1.8708179484499803 3.811579465866089 1.5423688888549805 2.2692105770111084 0.513954686544276 1.9057897329330444 1.7210520000000002 21.816148 1.9382727999999996 7.932717199999999 -8.382547999999993 80.841748 UP 1.0 0.0 0.0 GO:0030030 5 cell projection organization 158 167 5 5 2 3 2 2 50 165 2330 0.32599 0.86599 0.5784 1.2 308843;338475 tsku;nrep TSKU_10094;NREP_9364 59.37513 59.37513 6.12626 75.30527413504183 63.32805895919909 75.09749009015448 40.464075 40.464075 1.46625 55.15125301805254 43.35907787589725 54.99907841190017 116.83645 116.83645 41.3339 106.77673020375272 122.44138051567813 106.48210939323955 6.12626;112.624 1.46625;79.4619 41.3339;192.339 0 2 0 2 308843;338475 TSKU_10094;NREP_9364 59.37513 59.37513 75.30527413504183 40.464075 40.464075 55.15125301805254 116.83645 116.83645 106.77673020375272 6.12626;112.624 1.46625;79.4619 41.3339;192.339 0 Hill,1(0.5);Poly 2,1(0.5) 2.0780754659794987 4.19093644618988 1.826043963432312 2.3648924827575684 0.38102344204721916 2.09546822309494 -44.9926552 163.7429152 -35.97166199999999 116.899812 -31.148547999999963 264.821448 DOWN 0.0 1.0 0.0 GO:0045931 7 positive regulation of mitotic cell cycle 58 63 4 4 3 3 3 3 49 60 2435 0.96207 0.13589 0.13589 4.76 24296;58919;25612 cyp1a1;ccnd1;asns CYP1A1_8415;CCND1_8224;ASNS_8091 256.20966666666664 154.987 100.909 223.79515841352185 249.0826392983184 233.17689477849405 152.32716666666667 73.3629 53.5946 154.20706810565898 157.91935849595185 151.73320552052706 541.52 462.615 159.385 427.08959180129875 490.80327434087604 467.5789525576268 100.909;512.733;154.987 73.3629;330.024;53.5946 159.385;1002.56;462.615 2 1 2 24296;25612 CYP1A1_8415;ASNS_8091 127.94800000000001 127.94800000000001 38.23892051300602 63.47875 63.47875 13.978298982530077 311.0 311.0 214.41598925919683 100.909;154.987 73.3629;53.5946 159.385;462.615 1 58919 CCND1_8224 512.733 512.733 330.024 330.024 1002.56 1002.56 512.733 330.024 1002.56 0 Exp 2,1(0.34);Exp 4,1(0.34);Poly 2,1(0.34) 1.9840681835237715 6.09581732749939 1.555469274520874 2.634152889251709 0.5502256264781237 1.9061951637268066 2.961604558038374 509.45772877529487 -22.174558205553865 326.8288915388872 58.222630042648234 1024.8173699573517 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0032787 7 monocarboxylic acid metabolic process 180 207 27 24 14 21 13 13 39 194 2301 0.99996 1.7033E-4 1.7033E-4 6.28 286954;501907;24539;24424;25598;25315;499353;29277;24296;290277;25612;24188;24763 ugt2b1;rgd1559459;lpl;gstm2;fabp2;ephx1;cyp2c24;cyp2c11;cyp1a1;cryl1;asns;aldh1a1;acsm3 UGT2B10_33303,UGT2B1_33224;RGD1559459_9690;LPL_32544;GSTM2_8759;FABP2_32859;EPHX1_8567;CYP2C24_32875;CYP2C11_32593;CYP1A1_8415;CRYL1_8388;ASNS_8091;ALDH1A1_8022;ACSM3_7976 212.07266769230768 100.909 3.28268 265.68282565526744 287.6415976360789 310.1422496682619 126.52359053846155 53.5946 0.808077 168.08923560556616 176.73383976295108 190.30312755091884 506.80326538461543 250.463 13.1174 686.8664790470741 694.8941692645202 834.1551089489744 9.5 307.556 25.4966;42.78;769.435;3.28268;146.645;24.8784;733.935;129.934;100.909;76.0301;154.987;88.5069;460.125 11.3392;20.6065;444.211;0.808077;95.8536;15.4867;463.206;45.3106;73.3629;23.2788;53.5946;65.9487;331.8 63.97775;93.6128;2183.16;13.1174;319.535;41.3795;1763.75;355.143;159.385;250.463;462.615;133.645;748.659 10 4 9 286954;501907;24424;25598;25315;24296;290277;25612;24188 UGT2B10_33303,UGT2B1_33224;RGD1559459_9690;GSTM2_8759;FABP2_32859;EPHX1_8567;CYP1A1_8415;CRYL1_8388;ASNS_8091;ALDH1A1_8022 73.72396444444445 76.0301 54.21635974739432 40.03100855555556 23.2788 32.986557470625954 170.8589388888889 133.645 147.5285472827119 25.4966;42.78;3.28268;146.645;24.8784;100.909;76.0301;154.987;88.5069 11.3392;20.6065;0.808077;95.8536;15.4867;73.3629;23.2788;53.5946;65.9487 63.97775;93.6128;13.1174;319.535;41.3795;159.385;250.463;462.615;133.645 4 24539;499353;29277;24763 LPL_32544;CYP2C24_32875;CYP2C11_32593;ACSM3_7976 523.35725 597.03 296.4666473207116 321.1319 388.0055 192.80794644664766 1262.6779999999999 1256.2045 853.6579272155794 769.435;733.935;129.934;460.125 444.211;463.206;45.3106;331.8 2183.16;1763.75;355.143;748.659 0 Exp 2,1(0.08);Exp 4,6(0.43);Hill,2(0.15);Linear,2(0.15);Poly 2,3(0.22) 1.9548954074875797 27.867160439491272 1.620619773864746 2.79919695854187 0.41143095706535465 1.806051790714264 67.64583847815047 356.49949690646486 35.14924120418033 217.89793987274274 133.41839409082996 880.1881366784007 UP 0.6923076923076923 0.3076923076923077 0.0 GO:0090304 5 nucleic acid metabolic process 251 278 9 9 4 5 2 2 50 276 2219 0.065016 0.98271 0.11566 0.72 307126;24330 mcm10;egr1 MCM10_32579;EGR1_8533 110.935675 110.935675 8.26335 145.2005944953782 135.28724464719272 141.05748740583422 62.34689 62.34689 1.51678 86.02676656264724 76.77442595295904 83.57210645829358 357.00010000000003 357.00010000000003 45.9052 439.9546267651017 430.7848236267072 427.4011028655411 213.608;8.26335 123.177;1.51678 668.095;45.9052 0 2 0 2 307126;24330 MCM10_32579;EGR1_8533 110.935675 110.935675 145.2005944953782 62.34689 62.34689 86.02676656264724 357.00010000000003 357.00010000000003 439.9546267651017 213.608;8.26335 123.177;1.51678 668.095;45.9052 0 Hill,1(0.5);Poly 2,1(0.5) 3.3361407735056408 7.393849849700928 2.103997230529785 5.289852619171143 2.252739949188008 3.696924924850464 -90.30208199999998 312.173432 -56.8801256 181.5739056 -252.74590399999983 966.7461039999998 DOWN 0.0 1.0 0.0 GO:0010605 6 negative regulation of macromolecule metabolic process 531 562 32 30 15 20 11 11 41 551 1944 0.5157 0.61829 1.0 1.96 24522;246273;299270;360918;24614;24484;25587;297417;24330;25695;58919 zfp354a;trib3;serpina6;pf4;orm1;igfbp3;id2;gfpt1;egr1;cebpd;ccnd1 ZFP354A_10203;TRIB3_10079;SERPINA6_32325;PF4_32963;ORM1_9400;IGFBP3_8881;ID2_8861;GFPT1_8705;EGR1_8533;CEBPD_8283;CCND1_8224 166.24358818181818 16.8949 2.99674 309.9061603815151 111.68372318809608 216.48083057153772 95.56878490909092 7.7531 0.998544 181.47519804226772 63.747655607859436 135.1723080803405 566.8301363636364 58.9909 6.6682 1254.053749847921 305.7057542245439 677.0049525602807 3.26713;16.8949;15.8474;179.631;56.9823;44.9033;2.99674;981.5;8.26335;5.66035;512.733 1.71987;6.46469;7.7531;110.795;16.0812;18.8755;0.998544;554.87;1.51678;2.15795;330.024 6.6682;58.9909;40.8362;426.677;262.985;122.765;10.914;4240.48;45.9052;16.35;1002.56 5 6 5 246273;360918;24614;25587;297417 TRIB3_10079;PF4_32963;ORM1_9400;ID2_8861;GFPT1_8705 247.600988 56.9823 416.1188833969347 137.8418868 16.0812 237.4108856194446 1000.0093799999999 262.985 1819.0925103051304 16.8949;179.631;56.9823;2.99674;981.5 6.46469;110.795;16.0812;0.998544;554.87 58.9909;426.677;262.985;10.914;4240.48 6 24522;299270;24484;24330;25695;58919 ZFP354A_10203;SERPINA6_32325;IGFBP3_8881;EGR1_8533;CEBPD_8283;CCND1_8224 98.445755 12.055375000000002 203.5309177080041 60.34119999999999 4.955525 132.28438188524584 205.84743333333333 43.3707 392.43992507750613 3.26713;15.8474;44.9033;8.26335;5.66035;512.733 1.71987;7.7531;18.8755;1.51678;2.15795;330.024 6.6682;40.8362;122.765;45.9052;16.35;1002.56 0 Exp 2,1(0.1);Exp 4,6(0.55);Hill,2(0.19);Linear,1(0.1);Poly 2,1(0.1) 2.172836033633191 27.600967049598694 1.5232417583465576 6.495501518249512 1.7088975366010748 1.8130581378936768 -16.899249112924707 349.38642547656104 -11.676203790619638 202.81377360880145 -174.2682709236525 1307.928543650925 CONFLICT 0.45454545454545453 0.5454545454545454 0.0 GO:0015850 6 organic hydroxy compound transport 49 50 5 5 4 4 3 3 49 47 2448 0.9822 0.0804 0.0804 6.0 170698;114628;140668 slco1a2;abcg5;abcc3 SLCO1A2_9886;ABCG5_7947;ABCC3_7941 296.1513 360.968 86.4919 185.9269700050803 268.3347740403991 185.58579650310082 204.48259999999996 273.647 40.4498 142.6367537168454 185.82761909863862 145.9545748477158 469.70966666666664 528.588 108.02 336.14042951173445 412.8061718680886 324.58649431462806 1.5 400.981 440.994;360.968;86.4919 299.351;273.647;40.4498 772.521;528.588;108.02 1 2 1 140668 ABCC3_7941 86.4919 86.4919 40.4498 40.4498 108.02 108.02 86.4919 40.4498 108.02 2 170698;114628 SLCO1A2_9886;ABCG5_7947 400.981 400.981 56.586927271234906 286.499 286.499 18.175472703617977 650.5545 650.5545 172.4866784551777 440.994;360.968 299.351;273.647 772.521;528.588 0 Exp 2,1(0.34);Exp 5,1(0.34);Linear,1(0.34) 2.2974457658307057 7.193539500236511 1.672735333442688 3.368933916091919 0.8744430481103227 2.1518702507019043 85.75512708319269 506.5474729168073 43.073918416680186 365.8912815833198 89.33096243699868 850.0883708963346 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0098856 6 intestinal lipid absorption 3 3 1 1 1 1 1 1 51 2 2493 0.99879 0.06003 0.06003 33.33 25598 fabp2 FABP2_32859 146.645 146.645 146.645 146.645 95.8536 95.8536 95.8536 95.8536 319.535 319.535 319.535 319.535 0.0 146.645 0.0 146.645 146.645 95.8536 319.535 1 0 1 25598 FABP2_32859 146.645 146.645 95.8536 95.8536 319.535 319.535 146.645 95.8536 319.535 0 0 Poly 2,1(1) 2.089545965194702 2.089545965194702 2.089545965194702 2.089545965194702 0.0 2.089545965194702 146.645 146.645 95.8536 95.8536 319.535 319.535 UP 1.0 0.0 0.0 GO:0045893 8 positive regulation of transcription, DNA-templated 299 321 17 16 9 12 8 8 44 313 2182 0.79942 0.32936 0.52566 2.49 360918;316351;83619;29200;494344;25587;24330;25695 pf4;npas2;nfe2l2;inhba;ier2;id2;egr1;cebpd PF4_32963;NPAS2_9350;NFE2L2_9301;INHBA_33300;IER2_32643;ID2_8861;EGR1_8533;CEBPD_8283 126.4199675 69.215675 2.99674 183.23406085529516 117.02768478833491 175.8396553030231 80.08880925 30.0656 0.998544 127.32715478131114 69.94967207557227 122.28429420854219 255.5048125 138.6176 10.914 333.1671544331654 240.35741427093134 317.8211081606684 179.631;134.458;6.6423;130.168;543.54;2.99674;8.26335;5.66035 110.795;56.7249;3.4063;89.164;375.947;0.998544;1.51678;2.15795 426.677;320.448;13.4683;231.33;978.946;10.914;45.9052;16.35 3 5 3 360918;83619;25587 PF4_32963;NFE2L2_9301;ID2_8861 63.09001333333333 6.6423 100.94391366921799 38.399948 3.4063 62.70751141451009 150.3531 13.4683 239.3069250889535 179.631;6.6423;2.99674 110.795;3.4063;0.998544 426.677;13.4683;10.914 5 316351;29200;494344;24330;25695 NPAS2_9350;INHBA_33300;IER2_32643;EGR1_8533;CEBPD_8283 164.41794 130.168 221.01607471750043 105.102126 56.7249 155.94770991119228 318.59584 231.33 390.318403383863 134.458;130.168;543.54;8.26335;5.66035 56.7249;89.164;375.947;1.51678;2.15795 320.448;231.33;978.946;45.9052;16.35 0 Exp 4,2(0.25);Hill,3(0.38);Linear,1(0.13);Poly 2,2(0.25) 1.973194881084109 17.342979311943054 1.5423688888549805 5.289852619171143 1.2724967809856356 1.7477684020996094 -0.554758535625183 253.39469353562518 -8.144407433553155 168.32202593355316 24.63175341504936 486.37787158495064 DOWN 0.375 0.625 0.0 GO:0009967 6 positive regulation of signal transduction 363 381 9 8 6 5 4 4 48 377 2118 0.092078 0.9638 0.1693 1.05 29200;24484;24424;289388 inhba;igfbp3;gstm2;g0s2 INHBA_33300;IGFBP3_8881;GSTM2_8759;G0S2_32729 45.451205 24.17707 3.28268 59.77583323208441 56.1677266634126 46.30509563986716 27.48032925 9.97462 0.808077 41.98267626661386 30.559437104874135 34.97461976633889 95.38365 68.5436 13.1174 104.19507821279277 128.84912317132697 74.05562876396252 130.168;44.9033;3.28268;3.45084 89.164;18.8755;0.808077;1.07374 231.33;122.765;13.1174;14.3222 2 2 2 24424;289388 GSTM2_8759;G0S2_32729 3.36676 3.36676 0.118907076324308 0.9409084999999999 0.9409084999999999 0.18785210881036196 13.7198 13.7198 0.8519222499735996 3.28268;3.45084 0.808077;1.07374 13.1174;14.3222 2 29200;24484 INHBA_33300;IGFBP3_8881 87.53565 87.53565 60.291247565836635 54.01975 54.01975 49.70147498943065 177.0475 177.0475 76.7670476995175 130.168;44.9033 89.164;18.8755 231.33;122.765 0 Exp 4,2(0.5);Hill,1(0.25);Poly 2,1(0.25) 1.7605615574019693 7.0770450830459595 1.6357452869415283 2.0805697441101074 0.2096421537604837 1.6803650259971619 -13.12911156744272 104.03152156744272 -13.662693491281573 68.62335199128158 -6.727526648536909 197.4948266485369 CONFLICT 0.5 0.5 0.0 GO:0071383 6 cellular response to steroid hormone stimulus 54 60 8 8 4 6 4 4 48 56 2439 0.99319 0.032469 0.032469 6.67 286954;24614;25315;24330 ugt2b1;orm1;ephx1;egr1 UGT2B10_33303,UGT2B1_33224;ORM1_9400;EPHX1_8567;EGR1_8533 28.905162500000003 25.1875 8.26335 20.3489818584524 35.561711453919166 23.84453146956106 11.10597 13.41295 1.51678 6.73178208141054 11.40421438108691 6.903502630617643 103.5618625 54.941475 41.3795 106.72952679472361 148.68910973285753 121.50522060246318 2.0 25.4966 25.4966;56.9823;24.8784;8.26335 11.3392;16.0812;15.4867;1.51678 63.97775;262.985;41.3795;45.9052 4 1 3 286954;24614;25315 UGT2B10_33303,UGT2B1_33224;ORM1_9400;EPHX1_8567 35.78576666666667 25.4966 18.359338545365212 14.302366666666666 15.4867 2.5833360376329906 122.78075000000001 63.97775 121.94504505847091 25.4966;56.9823;24.8784 11.3392;16.0812;15.4867 63.97775;262.985;41.3795 1 24330 EGR1_8533 8.26335 8.26335 1.51678 1.51678 45.9052 45.9052 8.26335 1.51678 45.9052 0 Exp 4,4(0.8);Hill,1(0.2) 2.2969166451000684 12.912842869758606 1.5846891403198242 5.289852619171143 1.5719179610042022 1.7026138305664062 8.96316027871665 48.847164721283356 4.508823560217674 17.703116439782328 -1.0330737588291186 208.15679875882915 UP 0.75 0.25 0.0 GO:0006869 6 lipid transport 73 76 7 7 5 7 5 5 47 71 2424 0.99605 0.018031 0.018031 6.58 170698;29200;25598;114628;140668 slco1a2;inhba;fabp2;abcg5;abcc3 SLCO1A2_9886;INHBA_33300;FABP2_32859;ABCG5_7947;ABCC3_7941 233.05338 146.645 86.4919 157.42738677521137 232.24813230378678 157.30646235713334 159.69308 95.8536 40.4498 118.06631680920681 159.71208513503984 122.07968127134998 391.99879999999996 319.535 108.02 262.27999290014475 377.3607359847684 260.01801488465486 2.5 253.80650000000003 440.994;130.168;146.645;360.968;86.4919 299.351;89.164;95.8536;273.647;40.4498 772.521;231.33;319.535;528.588;108.02 2 3 2 25598;140668 FABP2_32859;ABCC3_7941 116.56845000000001 116.56845000000001 42.534664919392476 68.1517 68.1517 39.17640268350323 213.7775 213.7775 149.56369082267264 146.645;86.4919 95.8536;40.4498 319.535;108.02 3 170698;29200;114628 SLCO1A2_9886;INHBA_33300;ABCG5_7947 310.71000000000004 360.968 161.39269033013846 220.7206666666667 273.647 114.65400696152459 510.81299999999993 528.588 271.033000922397 440.994;130.168;360.968 299.351;89.164;273.647 772.521;231.33;528.588 0 Exp 2,1(0.2);Exp 5,1(0.2);Linear,1(0.2);Poly 2,2(0.4) 2.1062052074649698 10.918830752372742 1.6357452869415283 3.368933916091919 0.7028507642484771 2.089545965194702 95.06219136698655 371.04456863301345 56.20339038654225 263.1827696134577 162.10024984094872 621.8973501590513 DOWN 0.4 0.6 0.0 GO:0010558 7 negative regulation of macromolecule biosynthetic process 265 277 19 17 9 13 8 8 44 269 2226 0.89539 0.19776 0.26384 2.89 24522;246273;360918;25587;297417;24330;25695;58919 zfp354a;trib3;pf4;id2;gfpt1;egr1;cebpd;ccnd1 ZFP354A_10203;TRIB3_10079;PF4_32963;ID2_8861;GFPT1_8705;EGR1_8533;CEBPD_8283;CCND1_8224 213.86830874999998 12.579125000000001 2.99674 357.16999999994744 151.22858318739503 273.4292841994951 126.06835425 4.31132 0.998544 207.70134967030904 93.29493236181067 168.50513829763182 726.0681625 52.44805 6.6682 1461.773323741557 382.173484779801 869.2363260759491 3.26713;16.8949;179.631;2.99674;981.5;8.26335;5.66035;512.733 1.71987;6.46469;110.795;0.998544;554.87;1.51678;2.15795;330.024 6.6682;58.9909;426.677;10.914;4240.48;45.9052;16.35;1002.56 4 4 4 246273;360918;25587;297417 TRIB3_10079;PF4_32963;ID2_8861;GFPT1_8705 295.25566 98.26295 464.4711491612424 168.2820585 58.629845 262.6300524692013 1184.265475 242.83395000000002 2045.921477256634 16.8949;179.631;2.99674;981.5 6.46469;110.795;0.998544;554.87 58.9909;426.677;10.914;4240.48 4 24522;24330;25695;58919 ZFP354A_10203;EGR1_8533;CEBPD_8283;CCND1_8224 132.4809575 6.96185 253.50957216793915 83.85465 1.93891 164.11311809449987 267.87084999999996 31.1276 490.0770209056905 3.26713;8.26335;5.66035;512.733 1.71987;1.51678;2.15795;330.024 6.6682;45.9052;16.35;1002.56 0 Exp 2,1(0.13);Exp 4,3(0.38);Hill,2(0.25);Linear,1(0.13);Poly 2,1(0.13) 2.392068916242626 22.54839813709259 1.5232417583465576 6.495501518249512 1.9408552411572726 1.9187628626823425 -33.63787370563469 461.37449120563474 -17.86133790720433 269.99804640720436 -286.88907067974844 1739.0253956797483 CONFLICT 0.5 0.5 0.0 GO:0051128 5 regulation of cellular component organization 515 547 17 15 6 9 4 4 48 543 1952 0.0067855 0.99818 0.010422 0.73 363140;83619;29200;24484 rassf1;nfe2l2;inhba;igfbp3 RASSF1_32475;NFE2L2_9301;INHBA_33300;IGFBP3_8881 234.57365000000001 87.53565 6.6423 351.81422900345666 321.1172097481306 396.7665341789818 137.23645 54.01975 3.4063 203.62464114274087 184.62932430932702 230.9925169736222 326.93757500000004 177.0475 13.4683 418.3957824880518 432.29509400629667 465.0819732944025 756.581;6.6423;130.168;44.9033 437.5;3.4063;89.164;18.8755 940.187;13.4683;231.33;122.765 2 2 2 363140;83619 RASSF1_32475;NFE2L2_9301 381.61165 381.61165 530.2867402442239 220.45315 220.45315 306.9505989403588 476.82765 476.82765 655.2890770223818 756.581;6.6423 437.5;3.4063 940.187;13.4683 2 29200;24484 INHBA_33300;IGFBP3_8881 87.53565 87.53565 60.291247565836635 54.01975 54.01975 49.70147498943065 177.0475 177.0475 76.7670476995175 130.168;44.9033 89.164;18.8755 231.33;122.765 0 Exp 4,2(0.5);Poly 2,2(0.5) 1.7398308588169848 7.027624845504761 1.5423688888549805 2.1946890354156494 0.29596243808222833 1.6452834606170654 -110.20429442338752 579.3515944233875 -62.31569831988605 336.78859831988603 -83.09029183829085 736.9654418382909 CONFLICT 0.5 0.5 0.0 GO:0016999 5 antibiotic metabolic process 46 51 6 6 3 5 2 2 50 49 2446 0.91576 0.27961 0.27961 3.92 286954;24296 ugt2b1;cyp1a1 UGT2B10_33303,UGT2B1_33224;CYP1A1_8415 63.2028 63.2028 25.4966 53.32461942555239 78.24823606035976 48.89565158976053 42.35105 42.35105 11.3392 43.85737886428006 54.72532283280913 40.21472895051517 111.681375 111.681375 63.97775 67.4631134493602 130.71595922712655 61.85984871370204 25.4966;100.909 11.3392;73.3629 63.97775;159.385 3 0 2 286954;24296 UGT2B10_33303,UGT2B1_33224;CYP1A1_8415 63.2028 63.2028 53.32461942555239 42.35105 42.35105 43.85737886428006 111.681375 111.681375 67.4631134493602 25.4966;100.909 11.3392;73.3629 63.97775;159.385 0 0 Exp 4,2(0.67);Poly 2,1(0.34) 1.7665713939509882 5.307483077049255 1.6986740827560425 1.9061951637268066 0.11869139246483551 1.7026138305664062 -10.701351999999993 137.106952 -18.432175999999984 103.13427599999999 18.18227000000003 205.18048 UP 1.0 0.0 0.0 GO:0051239 4 regulation of multicellular organismal process 724 769 40 37 20 28 16 16 36 753 1742 0.60337 0.51654 1.0 2.08 360918;24614;338475;316351;83619;25333;59107;24539;29200;25587;289388;24330;25695;58919;24188;114628 pf4;orm1;nrep;npas2;nfe2l2;mgp;ltbp1;lpl;inhba;id2;g0s2;egr1;cebpd;ccnd1;aldh1a1;abcg5 PF4_32963;ORM1_9400;NREP_9364;NPAS2_9350;NFE2L2_9301;MGP_33209;LTBP1_33264;LPL_32544;INHBA_33300;ID2_8861;G0S2_32729;EGR1_8533;CEBPD_8283;CCND1_8224;ALDH1A1_8022;ABCG5_7947 215.39983 100.56545 2.99674 298.58391862709277 271.6974203091758 327.57044970913716 124.76801337500001 61.3368 0.998544 168.09250782543353 154.93959108111997 185.18145380248365 674.67766875 247.15750000000003 10.914 1291.4140013244091 873.2330452296703 1428.9149654974653 179.631;56.9823;112.624;134.458;6.6423;75.1005;998.777;769.435;130.168;2.99674;3.45084;8.26335;5.66035;512.733;88.5069;360.968 110.795;16.0812;79.4619;56.7249;3.4063;13.9312;507.146;444.211;89.164;0.998544;1.07374;1.51678;2.15795;330.024;65.9487;273.647 426.677;262.985;192.339;320.448;13.4683;346.231;5065.92;2183.16;231.33;10.914;14.3222;45.9052;16.35;1002.56;133.645;528.588 6 10 6 360918;24614;83619;25587;289388;24188 PF4_32963;ORM1_9400;NFE2L2_9301;ID2_8861;G0S2_32729;ALDH1A1_8022 56.36834666666667 31.8123 69.78311526855495 33.05058066666667 9.743749999999999 45.48203083219677 143.66858333333334 73.98360000000001 170.72611017105046 179.631;56.9823;6.6423;2.99674;3.45084;88.5069 110.795;16.0812;3.4063;0.998544;1.07374;65.9487 426.677;262.985;13.4683;10.914;14.3222;133.645 10 338475;316351;25333;59107;24539;29200;24330;25695;58919;114628 NREP_9364;NPAS2_9350;MGP_33209;LTBP1_33264;LPL_32544;INHBA_33300;EGR1_8533;CEBPD_8283;CCND1_8224;ABCG5_7947 310.81872 132.313 344.8257545843844 179.798473 84.31295 192.2750496674299 993.28312 333.3395 1569.2743046937226 112.624;134.458;75.1005;998.777;769.435;130.168;8.26335;5.66035;512.733;360.968 79.4619;56.7249;13.9312;507.146;444.211;89.164;1.51678;2.15795;330.024;273.647 192.339;320.448;346.231;5065.92;2183.16;231.33;45.9052;16.35;1002.56;528.588 0 Exp 2,3(0.19);Exp 4,4(0.25);Hill,4(0.25);Linear,1(0.07);Poly 2,4(0.25) 1.9569170754318816 33.12168300151825 1.5423688888549805 5.289852619171143 0.9161552239220668 1.8429177403450012 69.09370987272453 361.7059501272754 42.402684540537535 207.13334220946246 41.88480810103965 1307.4705293989607 DOWN 0.375 0.625 0.0 GO:0009617 5 response to bacterium 110 127 7 7 3 5 2 2 50 125 2370 0.51497 0.74223 1.0 1.57 24539;54232 lpl;car3 LPL_32544;CAR3_8196 412.3225 412.3225 55.21 505.03334079296184 669.5132605573111 350.37765436797423 234.43605 234.43605 24.6611 296.66657933613794 385.51499273197356 205.8187683885588 1144.937 1144.937 106.714 1468.2690473676817 1892.660372881356 1018.6429751153523 769.435;55.21 444.211;24.6611 2183.16;106.714 0 2 0 2 24539;54232 LPL_32544;CAR3_8196 412.3225 412.3225 505.03334079296184 234.43605 234.43605 296.66657933613794 1144.937 1144.937 1468.2690473676817 769.435;55.21 444.211;24.6611 2183.16;106.714 0 Exp 2,1(0.5);Exp 5,1(0.5) 2.157836948161593 4.445041537284851 1.6902254819869995 2.7548160552978516 0.7527792135753778 2.2225207686424255 -287.6179999999998 1112.263 -176.72285200000002 645.594952 -889.9800799999998 3179.8540799999996 DOWN 0.0 1.0 0.0 GO:0009725 4 response to hormone 388 419 39 36 23 28 19 19 33 400 2095 0.9999 3.2492E-4 4.0359E-4 4.53 286954;246273;170698;24614;24314;83619;25333;59107;29200;24484;25587;24424;297417;25315;24330;58919;25612;24188;140668 ugt2b1;trib3;slco1a2;orm1;nqo1;nfe2l2;mgp;ltbp1;inhba;igfbp3;id2;gstm2;gfpt1;ephx1;egr1;ccnd1;asns;aldh1a1;abcc3 UGT2B10_33303,UGT2B1_33224;TRIB3_10079;SLCO1A2_9886;ORM1_9400;NQO1_33055;NFE2L2_9301;MGP_33209;LTBP1_33264;INHBA_33300;IGFBP3_8881;ID2_8861;GSTM2_8759;GFPT1_8705;EPHX1_8567;EGR1_8533;CCND1_8224;ASNS_8091;ALDH1A1_8022;ABCC3_7941 193.87950368421053 56.9823 2.99674 313.893379028162 194.90883508962457 300.1862538382125 107.67744163157896 16.4151 0.808077 176.63877901982346 105.16740776345749 166.4701961318852 685.9930763157895 122.765 10.914 1430.2367520651871 691.5573104000376 1425.410747897884 25.4966;16.8949;440.994;56.9823;24.1117;6.6423;75.1005;998.777;130.168;44.9033;2.99674;3.28268;981.5;24.8784;8.26335;512.733;154.987;88.5069;86.4919 11.3392;6.46469;299.351;16.0812;16.4151;3.4063;13.9312;507.146;89.164;18.8755;0.998544;0.808077;554.87;15.4867;1.51678;330.024;53.5946;65.9487;40.4498 63.97775;58.9909;772.521;262.985;37.0434;13.4683;346.231;5065.92;231.33;122.765;10.914;13.1174;4240.48;41.3795;45.9052;1002.56;462.615;133.645;108.02 13 7 12 286954;246273;24614;24314;83619;25587;24424;297417;25315;25612;24188;140668 UGT2B10_33303,UGT2B1_33224;TRIB3_10079;ORM1_9400;NQO1_33055;NFE2L2_9301;ID2_8861;GSTM2_8759;GFPT1_8705;EPHX1_8567;ASNS_8091;ALDH1A1_8022;ABCC3_7941 122.73095166666667 25.1875 274.254292174975 65.48857591666668 15.78395 155.57079461360635 453.88635416666665 61.484325 1199.748077619018 25.4966;16.8949;56.9823;24.1117;6.6423;2.99674;3.28268;981.5;24.8784;154.987;88.5069;86.4919 11.3392;6.46469;16.0812;16.4151;3.4063;0.998544;0.808077;554.87;15.4867;53.5946;65.9487;40.4498 63.97775;58.9909;262.985;37.0434;13.4683;10.914;13.1174;4240.48;41.3795;462.615;133.645;108.02 7 170698;25333;59107;29200;24484;24330;58919 SLCO1A2_9886;MGP_33209;LTBP1_33264;INHBA_33300;IGFBP3_8881;EGR1_8533;CCND1_8224 315.84845 130.168 360.8492326236691 180.00121142857142 89.164 198.92366904334 1083.8903142857143 346.231 1790.358493360913 440.994;75.1005;998.777;130.168;44.9033;8.26335;512.733 299.351;13.9312;507.146;89.164;18.8755;1.51678;330.024 772.521;346.231;5065.92;231.33;122.765;45.9052;1002.56 0 Exp 2,3(0.15);Exp 4,9(0.45);Exp 5,1(0.05);Hill,4(0.2);Linear,1(0.05);Poly 2,2(0.1) 2.1142582324538814 45.68785798549652 1.5232417583465576 5.289852619171143 1.0724477192124997 1.7042611241340637 52.7358270667724 335.0231803016486 28.250959998666687 187.1039232644912 42.880200711769476 1329.105951919809 UP 0.631578947368421 0.3684210526315789 0.0 GO:2001239 8 regulation of extrinsic apoptotic signaling pathway in absence of ligand 18 19 2 2 2 2 2 2 50 17 2478 0.99382 0.056032 0.056032 10.53 360918;29200 pf4;inhba PF4_32963;INHBA_33300 154.8995 154.8995 130.168 34.97562271783034 142.88274523264687 30.569419265379917 99.9795 99.9795 89.164 15.295426783846173 94.72437147215867 13.368520068120308 329.00350000000003 329.00350000000003 231.33 138.13118838444848 281.54505644546146 120.72952197064882 0.0 130.168 0.5 154.8995 179.631;130.168 110.795;89.164 426.677;231.33 1 1 1 360918 PF4_32963 179.631 179.631 110.795 110.795 426.677 426.677 179.631 110.795 426.677 1 29200 INHBA_33300 130.168 130.168 89.164 89.164 231.33 231.33 130.168 89.164 231.33 0 Poly 2,2(1) 1.7441746498123694 3.4955368041992188 1.6357452869415283 1.8597915172576904 0.15842460875584127 1.7477684020996094 106.42576 203.37323999999998 78.78112 121.17788 137.56344000000004 520.44356 CONFLICT 0.5 0.5 0.0 GO:2001238 8 positive regulation of extrinsic apoptotic signaling pathway 16 17 2 2 2 2 2 2 50 15 2480 0.99554 0.045728 0.045728 11.76 29200;289388 inhba;g0s2 INHBA_33300;G0S2_32729 66.80942 66.80942 3.45084 89.60256312870072 96.52965888386125 79.13301536403908 45.11887 45.11887 1.07374 62.289220202486085 65.77955692307691 55.01108056716391 122.82610000000001 122.82610000000001 14.3222 153.44768695037408 173.72310286576166 135.51820109854364 0.0 3.45084 0.5 66.80942 130.168;3.45084 89.164;1.07374 231.33;14.3222 1 1 1 289388 G0S2_32729 3.45084 3.45084 1.07374 1.07374 14.3222 14.3222 3.45084 1.07374 14.3222 1 29200 INHBA_33300 130.168 130.168 89.164 89.164 231.33 231.33 130.168 89.164 231.33 0 Exp 4,1(0.5);Poly 2,1(0.5) 1.844798675487721 3.7163150310516357 1.6357452869415283 2.0805697441101074 0.31453839010152723 1.8581575155258179 -57.37339679999998 190.9922368 -41.20958479999999 131.4473248 -89.84154399999996 335.493744 CONFLICT 0.5 0.5 0.0 GO:0045597 6 positive regulation of cell differentiation 285 303 17 17 9 12 7 7 45 296 2199 0.72715 0.42542 0.66624 2.31 360918;83619;24539;29200;24484;25587;25695 pf4;nfe2l2;lpl;inhba;igfbp3;id2;cebpd PF4_32963;NFE2L2_9301;LPL_32544;INHBA_33300;IGFBP3_8881;ID2_8861;CEBPD_8283 162.77667 44.9033 2.99674 276.24534990020123 238.473093757872 351.0566911955154 95.65832771428572 18.8755 0.998544 160.14009233199883 136.8743962283332 203.75814561386724 429.2377571428571 122.765 10.914 788.2129714271049 660.3598654321357 1002.958354820891 179.631;6.6423;769.435;130.168;44.9033;2.99674;5.66035 110.795;3.4063;444.211;89.164;18.8755;0.998544;2.15795 426.677;13.4683;2183.16;231.33;122.765;10.914;16.35 3 4 3 360918;83619;25587 PF4_32963;NFE2L2_9301;ID2_8861 63.09001333333333 6.6423 100.94391366921799 38.399948 3.4063 62.70751141451009 150.3531 13.4683 239.3069250889535 179.631;6.6423;2.99674 110.795;3.4063;0.998544 426.677;13.4683;10.914 4 24539;29200;24484;25695 LPL_32544;INHBA_33300;IGFBP3_8881;CEBPD_8283 237.54166249999997 87.53565 358.3843875268363 138.6021125 54.01975 207.19748253586633 638.40125 177.0475 1033.5723000381975 769.435;130.168;44.9033;5.66035 444.211;89.164;18.8755;2.15795 2183.16;231.33;122.765;16.35 0 Exp 2,1(0.15);Exp 4,3(0.43);Hill,1(0.15);Poly 2,2(0.29) 1.699488681747203 11.938283681869507 1.5423688888549805 1.9777342081069946 0.15735081823501615 1.6548216342926025 -41.8687490687071 367.4220890687071 -22.9751128733036 214.29176830187507 -154.67858357152915 1013.1540978572434 CONFLICT 0.42857142857142855 0.5714285714285714 0.0 GO:0015711 6 organic anion transport 106 111 7 7 5 6 4 4 48 107 2388 0.92662 0.18881 0.28503 3.6 170698;266730;25598;140668 slco1a2;slc17a3;fabp2;abcc3 SLCO1A2_9886;SLC17A3_9840;FABP2_32859;ABCC3_7941 183.2224 116.56845000000001 58.7587 175.7195741375635 155.71781200858052 158.83426242036236 120.579975 71.25955 40.4498 121.73012166297418 100.64071511488801 110.53321434621283 319.742825 213.7775 78.8953 320.3343065570548 264.7689745266285 294.3288023097428 440.994;58.7587;146.645;86.4919 299.351;46.6655;95.8536;40.4498 772.521;78.8953;319.535;108.02 3 1 3 266730;25598;140668 SLC17A3_9840;FABP2_32859;ABCC3_7941 97.29853333333334 86.4919 44.928698233126376 60.98963333333334 46.6655 30.352608791063272 168.81676666666667 108.02 131.33564417881132 58.7587;146.645;86.4919 46.6655;95.8536;40.4498 78.8953;319.535;108.02 1 170698 SLCO1A2_9886 440.994 440.994 299.351 299.351 772.521 772.521 440.994 299.351 772.521 0 Exp 2,1(0.25);Exp 5,1(0.25);Poly 2,2(0.5) 2.1442659132493422 8.926539540290833 1.672735333442688 3.368933916091919 0.7781118086458901 1.9424351453781128 11.017217345187788 355.4275826548122 1.2844557702852768 239.87549422971472 5.8152045740862945 633.6704454259136 UP 0.75 0.25 0.0 GO:0062012 5 regulation of small molecule metabolic process 117 127 16 15 6 13 5 5 47 122 2373 0.9577 0.11432 0.18237 3.94 246273;24484;297417;246248;24330 trib3;igfbp3;gfpt1;fmo5;egr1 TRIB3_10079;IGFBP3_8881;GFPT1_8705;FMO5_33281;EGR1_8533 221.81187 44.9033 8.26335 425.151662818834 80.43322497220744 229.3603666490795 122.65517399999999 18.8755 1.51678 241.8961392751924 41.285542484412005 130.69273178458891 915.43342 109.026 45.9052 1859.0403455618145 296.2535334912272 1000.7548929318178 16.8949;44.9033;981.5;57.4978;8.26335 6.46469;18.8755;554.87;31.5489;1.51678 58.9909;122.765;4240.48;109.026;45.9052 3 2 3 246273;297417;246248 TRIB3_10079;GFPT1_8705;FMO5_33281 351.9642333333333 57.4978 545.5718192928804 197.62786333333335 31.5489 309.63488588247776 1469.4989666666663 109.026 2399.8703700674755 16.8949;981.5;57.4978 6.46469;554.87;31.5489 58.9909;4240.48;109.026 2 24484;24330 IGFBP3_8881;EGR1_8533 26.583325000000002 26.583325000000002 25.90835710733604 10.19614 10.19614 12.274468624718544 84.3351 84.3351 54.348085780641796 44.9033;8.26335 18.8755;1.51678 122.765;45.9052 0 Exp 4,2(0.4);Exp 5,1(0.2);Hill,1(0.2);Linear,1(0.2) 2.194272714501887 12.418308138847351 1.5232417583465576 5.289852619171143 1.5948396054885572 1.68118155002594 -150.84999337351323 594.4737333735131 -89.37614067832207 334.68648867832206 -714.0872895516397 2544.954129551639 UP 0.6 0.4 0.0 GO:0002931 4 response to ischemia 27 28 3 3 2 3 2 2 50 26 2469 0.98165 0.1104 0.1104 7.14 116686;24330 gsr;egr1 GSR_8755;EGR1_8533 41.448775000000005 41.448775000000005 8.26335 46.931278108115166 45.61895841812331 46.55925262909263 29.40174 29.40174 1.51678 39.43528861823126 32.905850548743366 39.12268404554538 76.2171 76.2171 45.9052 42.867500081297 80.02618735542221 42.52768827784461 0.5 41.448775000000005 74.6342;8.26335 57.2867;1.51678 106.529;45.9052 1 1 1 116686 GSR_8755 74.6342 74.6342 57.2867 57.2867 106.529 106.529 74.6342 57.2867 106.529 1 24330 EGR1_8533 8.26335 8.26335 1.51678 1.51678 45.9052 45.9052 8.26335 1.51678 45.9052 0 Hill,1(0.5);Poly 2,1(0.5) 3.2206402532068843 7.250686764717102 1.9608341455459595 5.289852619171143 2.353971537395657 3.625343382358551 -23.59465799999999 106.492208 -25.252781599999995 84.0562616 16.80577600000001 135.628424 CONFLICT 0.5 0.5 0.0 GO:0032869 7 cellular response to insulin stimulus 59 62 10 9 5 6 3 3 49 59 2436 0.96394 0.13123 0.13123 4.84 246273;297417;24330 trib3;gfpt1;egr1 TRIB3_10079;GFPT1_8705;EGR1_8533 335.55275 16.8949 8.26335 559.4233756742495 127.95449749374926 386.95414875654376 187.61715666666666 6.46469 1.51678 318.0599136258064 69.58089789974997 220.00567315328612 1448.4587 58.9909 45.9052 2417.970225959449 554.9886563162281 1670.7099253061224 16.8949;981.5;8.26335 6.46469;554.87;1.51678 58.9909;4240.48;45.9052 2 1 2 246273;297417 TRIB3_10079;GFPT1_8705 499.19745 499.19745 682.0788073771278 280.667345 280.667345 387.7811135397107 2149.7354499999997 2149.7354499999997 2956.7592980676327 16.8949;981.5 6.46469;554.87 58.9909;4240.48 1 24330 EGR1_8533 8.26335 8.26335 1.51678 1.51678 45.9052 45.9052 8.26335 1.51678 45.9052 0 Exp 4,1(0.34);Hill,1(0.34);Linear,1(0.34) 2.6344850363888077 9.082304954528809 1.5232417583465576 5.289852619171143 1.994496812154478 2.2692105770111084 -297.49439361153446 968.5998936115345 -172.30151776389874 547.5358310972322 -1287.7321912663688 4184.649591266369 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0071310 5 cellular response to organic substance 516 551 37 32 22 23 17 17 35 534 1961 0.97951 0.041488 0.060318 3.09 286954;246273;360918;24614;83619;59107;24539;29200;24484;25587;24424;297417;25315;24330;24296;58919;25612 ugt2b1;trib3;pf4;orm1;nfe2l2;ltbp1;lpl;inhba;igfbp3;id2;gstm2;gfpt1;ephx1;egr1;cyp1a1;ccnd1;asns UGT2B10_33303,UGT2B1_33224;TRIB3_10079;PF4_32963;ORM1_9400;NFE2L2_9301;LTBP1_33264;LPL_32544;INHBA_33300;IGFBP3_8881;ID2_8861;GSTM2_8759;GFPT1_8705;EPHX1_8567;EGR1_8533;CYP1A1_8415;CCND1_8224;ASNS_8091 236.38120999999998 56.9823 2.99674 349.6689767685059 275.91572519847585 359.55219406151525 131.65555829411764 18.8755 0.808077 194.64290550227702 153.45731659666384 198.40175015248332 847.3900029411765 159.385 10.914 1536.6445574399845 960.965950552854 1574.4959859832904 25.4966;16.8949;179.631;56.9823;6.6423;998.777;769.435;130.168;44.9033;2.99674;3.28268;981.5;24.8784;8.26335;100.909;512.733;154.987 11.3392;6.46469;110.795;16.0812;3.4063;507.146;444.211;89.164;18.8755;0.998544;0.808077;554.87;15.4867;1.51678;73.3629;330.024;53.5946 63.97775;58.9909;426.677;262.985;13.4683;5065.92;2183.16;231.33;122.765;10.914;13.1174;4240.48;41.3795;45.9052;159.385;1002.56;462.615 12 6 11 286954;246273;360918;24614;83619;25587;24424;297417;25315;24296;25612 UGT2B10_33303,UGT2B1_33224;TRIB3_10079;PF4_32963;ORM1_9400;NFE2L2_9301;ID2_8861;GSTM2_8759;GFPT1_8705;EPHX1_8567;CYP1A1_8415;ASNS_8091 141.29099272727274 25.4966 285.49673551056225 77.01883736363637 15.4867 162.43210774821432 523.0899863636364 63.97775 1243.873171417117 25.4966;16.8949;179.631;56.9823;6.6423;2.99674;3.28268;981.5;24.8784;100.909;154.987 11.3392;6.46469;110.795;16.0812;3.4063;0.998544;0.808077;554.87;15.4867;73.3629;53.5946 63.97775;58.9909;426.677;262.985;13.4683;10.914;13.1174;4240.48;41.3795;159.385;462.615 6 59107;24539;29200;24484;24330;58919 LTBP1_33264;LPL_32544;INHBA_33300;IGFBP3_8881;EGR1_8533;CCND1_8224 410.713275 321.4505 414.58335137913065 231.82288000000003 209.594 223.29085797759475 1441.9400333333333 616.9449999999999 1950.9180059006087 998.777;769.435;130.168;44.9033;8.26335;512.733 507.146;444.211;89.164;18.8755;1.51678;330.024 5065.92;2183.16;231.33;122.765;45.9052;1002.56 0 Exp 2,3(0.17);Exp 4,8(0.45);Hill,3(0.17);Linear,1(0.06);Poly 2,3(0.17) 1.9198465046785798 36.510451912879944 1.5232417583465576 5.289852619171143 0.8833752442009525 1.7006439566612244 70.1591296807255 402.6032903192746 39.12819435414764 224.18292223408764 116.9155484743003 1577.8644574080527 UP 0.6470588235294118 0.35294117647058826 0.0 GO:0048511 2 rhythmic process 111 122 12 10 7 10 6 6 46 116 2379 0.98921 0.035743 0.035743 4.92 316351;29200;25587;297417;24330;24188 npas2;inhba;id2;gfpt1;egr1;aldh1a1 NPAS2_9350;INHBA_33300;ID2_8861;GFPT1_8705;EGR1_8533;ALDH1A1_8022 224.31549833333335 109.33745 2.99674 375.3321169269345 121.00914040318781 200.0419410230201 128.20382066666667 61.3368 0.998544 212.03012098199792 67.26729569488067 113.49548205004537 830.4536999999999 182.4875 10.914 1674.5171496135772 341.16409729899493 877.7519026183276 134.458;130.168;2.99674;981.5;8.26335;88.5069 56.7249;89.164;0.998544;554.87;1.51678;65.9487 320.448;231.33;10.914;4240.48;45.9052;133.645 3 3 3 25587;297417;24188 ID2_8861;GFPT1_8705;ALDH1A1_8022 357.66787999999997 88.5069 541.9436154468261 207.27241466666666 65.9487 302.7749852419765 1461.6796666666667 133.645 2407.293956705398 2.99674;981.5;88.5069 0.998544;554.87;65.9487 10.914;4240.48;133.645 3 316351;29200;24330 NPAS2_9350;INHBA_33300;EGR1_8533 90.96311666666668 130.168 71.65221266674764 49.13522666666666 56.7249 44.31378058135114 199.2277333333333 231.33 140.05839461386572 134.458;130.168;8.26335 56.7249;89.164;1.51678 320.448;231.33;45.9052 0 Hill,3(0.5);Linear,1(0.17);Poly 2,2(0.34) 2.2727672816232056 15.114633321762085 1.5232417583465576 5.289852619171143 1.4295348759658435 1.9332983493804932 -76.01274404621003 524.6437407128766 -41.455610792116886 297.8632521254502 -509.4390768170409 2170.3464768170406 CONFLICT 0.5 0.5 0.0 GO:1902531 6 regulation of intracellular signal transduction 377 399 13 12 7 7 4 4 48 395 2100 0.071847 0.97302 0.1245 1.0 246273;83619;24484;24424 trib3;nfe2l2;igfbp3;gstm2 TRIB3_10079;NFE2L2_9301;IGFBP3_8881;GSTM2_8759 17.930795 11.7686 3.28268 18.89079579093392 29.902907711393656 20.532191627949043 7.38864175 4.9354949999999995 0.808077 7.999259914405764 12.571842746636216 8.58669522090473 52.0854 36.229600000000005 13.1174 51.8108007492003 82.88047845327738 55.95348576485042 16.8949;6.6423;44.9033;3.28268 6.46469;3.4063;18.8755;0.808077 58.9909;13.4683;122.765;13.1174 3 1 3 246273;83619;24424 TRIB3_10079;NFE2L2_9301;GSTM2_8759 8.93996 6.6423 7.091019985784838 3.559689 3.4063 2.831424340669021 28.525533333333332 13.4683 26.384364826603914 16.8949;6.6423;3.28268 6.46469;3.4063;0.808077 58.9909;13.4683;13.1174 1 24484 IGFBP3_8881 44.9033 44.9033 18.8755 18.8755 122.765 122.765 44.9033 18.8755 122.765 0 Exp 4,3(0.75);Hill,1(0.25) 1.772933676683158 7.172309517860413 1.5423688888549805 2.2692105770111084 0.32468992800182894 1.6803650259971619 -0.5821848751152423 36.44377487511524 -0.4506329661176478 15.227916466117648 1.3108152657837238 102.85998473421628 UP 0.75 0.25 0.0 GO:0051336 5 regulation of hydrolase activity 294 317 10 10 5 5 2 2 50 315 2180 0.033756 0.99208 0.05635 0.63 299270;24484 serpina6;igfbp3 SERPINA6_32325;IGFBP3_8881 30.37535 30.37535 15.8474 20.5456239234782 42.0292069105691 12.26775858178512 13.3143 13.3143 7.7531 7.864724463069256 17.77531680216802 4.696014167520064 81.8006 81.8006 40.8362 57.932410054476414 114.66093170731708 34.59134768826132 15.8474;44.9033 7.7531;18.8755 40.8362;122.765 0 2 0 2 299270;24484 SERPINA6_32325;IGFBP3_8881 30.37535 30.37535 20.5456239234782 13.3143 13.3143 7.864724463069256 81.8006 81.8006 57.932410054476414 15.8474;44.9033 7.7531;18.8755 40.8362;122.765 0 Exp 4,2(1) 1.7321338951757503 3.4678797721862793 1.6548216342926025 1.8130581378936768 0.11189010472756912 1.7339398860931396 1.9005680000000034 58.850132 2.414348000000002 24.214251999999995 1.510376000000008 162.090824 DOWN 0.0 1.0 0.0 GO:0030278 5 regulation of ossification 54 58 5 5 4 3 3 3 49 55 2440 0.9709 0.11318 0.11318 5.17 25333;25587;25695 mgp;id2;cebpd MGP_33209;ID2_8861;CEBPD_8283 27.919196666666664 5.66035 2.99674 40.88190605551597 43.286199041372356 42.77469714648513 5.695898 2.15795 0.998544 7.155501718371117 8.45341811183 7.375038463551685 124.49833333333333 16.35 10.914 192.045356945523 195.9493224312934 202.01363481565457 1.5 40.380424999999995 75.1005;2.99674;5.66035 13.9312;0.998544;2.15795 346.231;10.914;16.35 1 2 1 25587 ID2_8861 2.99674 2.99674 0.998544 0.998544 10.914 10.914 2.99674 0.998544 10.914 2 25333;25695 MGP_33209;CEBPD_8283 40.380424999999995 40.380424999999995 49.10160095161104 8.044575 8.044575 8.324944911604524 181.2905 181.2905 233.26109208459945 75.1005;5.66035 13.9312;2.15795 346.231;16.35 0 Exp 4,1(0.34);Hill,2(0.67) 1.8468339766999908 5.574253439903259 1.577596664428711 2.0189225673675537 0.24378101081512074 1.9777342081069946 -18.343035086962125 74.18142842029545 -2.4013144528452512 13.793110452845252 -92.82144618373297 341.81811285039964 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0045651 9 positive regulation of macrophage differentiation 7 7 3 3 2 2 2 2 50 5 2490 0.99973 0.0080418 0.0080418 28.57 360918;25587 pf4;id2 PF4_32963;ID2_8861 91.31387 91.31387 2.99674 124.89928303586774 62.40367175648703 118.01792990014424 55.896772 55.896772 0.998544 77.6378185878504 37.92609457085829 73.36034610438695 218.7955 218.7955 10.914 293.9888366664626 150.74646606786428 277.7914578353807 0.0 2.99674 0.0 2.99674 179.631;2.99674 110.795;0.998544 426.677;10.914 2 0 2 360918;25587 PF4_32963;ID2_8861 91.31387 91.31387 124.89928303586774 55.896772 55.896772 77.6378185878504 218.7955 218.7955 293.9888366664626 179.631;2.99674 110.795;0.998544 426.677;10.914 0 0 Hill,1(0.5);Poly 2,1(0.5) 1.9178564345716143 3.837525725364685 1.8597915172576904 1.9777342081069946 0.08339807649093156 1.9187628626823425 -81.78770479999999 264.4154448 -51.703754880000005 163.49729888000002 -188.65224 626.24324 UP 1.0 0.0 0.0 GO:0120162 5 positive regulation of cold-induced thermogenesis 37 42 4 4 2 2 1 1 51 41 2454 0.78906 0.5825 0.5825 2.38 289388 g0s2 G0S2_32729 3.45084 3.45084 3.45084 3.45084 1.07374 1.07374 1.07374 1.07374 14.3222 14.3222 14.3222 14.3222 3.45084 1.07374 14.3222 1 0 1 289388 G0S2_32729 3.45084 3.45084 1.07374 1.07374 14.3222 14.3222 3.45084 1.07374 14.3222 0 0 Exp 4,1(1) 2.0805697441101074 2.0805697441101074 2.0805697441101074 2.0805697441101074 0.0 2.0805697441101074 3.45084 3.45084 1.07374 1.07374 14.3222 14.3222 UP 1.0 0.0 0.0 GO:0052697 8 xenobiotic glucuronidation 1 7 1 1 1 1 1 1 51 6 2489 0.99196 0.1346 0.1346 14.29 501907 rgd1559459 RGD1559459_9690 42.78 42.78 42.78 42.78 20.6065 20.6065 20.6065 20.6065 93.6128 93.6128 93.6128 93.6128 0.0 42.78 0.0 42.78 42.78 20.6065 93.6128 1 0 1 501907 RGD1559459_9690 42.78 42.78 20.6065 20.6065 93.6128 93.6128 42.78 20.6065 93.6128 0 0 Exp 4,1(1) 2.0820155143737793 2.0820155143737793 2.0820155143737793 2.0820155143737793 0.0 2.0820155143737793 42.78 42.78 20.6065 20.6065 93.6128 93.6128 UP 1.0 0.0 0.0 GO:0045664 8 regulation of neuron differentiation 157 165 5 5 3 5 3 3 49 162 2333 0.56183 0.66584 1.0 1.82 338475;83619;25587 nrep;nfe2l2;id2 NREP_9364;NFE2L2_9301;ID2_8861 40.75434666666666 6.6423 2.99674 62.267630672914905 59.99280942567871 65.719149368113 27.95558133333333 3.4063 0.998544 44.62202336496011 41.72945419586059 47.11361924490222 72.24043333333333 13.4683 10.914 104.01625064701831 104.1538875279993 110.09054981667784 112.624;6.6423;2.99674 79.4619;3.4063;0.998544 192.339;13.4683;10.914 2 1 2 83619;25587 NFE2L2_9301;ID2_8861 4.81952 4.81952 2.57780019722243 2.202422 2.202422 1.7025405950425976 12.19115 12.19115 1.8061628511847745 6.6423;2.99674 3.4063;0.998544 13.4683;10.914 1 338475 NREP_9364 112.624 112.624 79.4619 79.4619 192.339 192.339 112.624 79.4619 192.339 0 Exp 4,1(0.34);Hill,1(0.34);Poly 2,1(0.34) 1.7726478587481538 5.346147060394287 1.5423688888549805 1.9777342081069946 0.22099186993843908 1.826043963432312 -29.708110661716262 111.21680399504959 -22.538991581695818 78.45015424836248 -45.465034876523816 189.94590154319047 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0051216 5 cartilage development 18 18 1 1 1 1 1 1 51 17 2478 0.94922 0.31103 0.31103 5.56 25333 mgp MGP_33209 75.1005 75.1005 75.1005 75.1005 13.9312 13.9312 13.9312 13.9312 346.231 346.231 346.231 346.231 0.0 75.1005 75.1005 13.9312 346.231 0 1 0 1 25333 MGP_33209 75.1005 75.1005 13.9312 13.9312 346.231 346.231 75.1005 13.9312 346.231 0 Hill,1(1) 2.0189225673675537 2.0189225673675537 2.0189225673675537 2.0189225673675537 0.0 2.0189225673675537 75.1005 75.1005 13.9312 13.9312 346.231 346.231 DOWN 0.0 1.0 0.0 GO:0031099 4 regeneration 111 120 8 8 5 5 3 3 49 117 2378 0.77245 0.44719 0.73443 2.5 24614;338475;58919 orm1;nrep;ccnd1 ORM1_9400;NREP_9364;CCND1_8224 227.44643333333332 112.624 56.9823 248.62686607658335 210.94934410984405 246.69375118424907 141.85569999999998 79.4619 16.0812 166.01132529677005 128.77222071677917 166.47377761830305 485.96133333333336 262.985 192.339 448.7798470634943 470.23687330695833 433.8361724794771 56.9823;112.624;512.733 16.0812;79.4619;330.024 262.985;192.339;1002.56 1 2 1 24614 ORM1_9400 56.9823 56.9823 16.0812 16.0812 262.985 262.985 56.9823 16.0812 262.985 2 338475;58919 NREP_9364;CCND1_8224 312.6785 312.6785 282.9197871137683 204.74295 204.74295 177.17416001834187 597.4495 597.4495 572.9127633597457 112.624;512.733 79.4619;330.024 192.339;1002.56 0 Exp 2,1(0.34);Exp 4,1(0.34);Poly 2,1(0.34) 1.651095711190519 4.96620237827301 1.555469274520874 1.826043963432312 0.1485017471706929 1.5846891403198242 -53.901351258560055 508.79421792522663 -46.00379936328875 329.7151993632888 -21.880871064282246 993.8035377309488 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0072593 4 reactive oxygen species metabolic process 40 44 4 4 2 3 2 2 50 42 2453 0.94089 0.2261 0.2261 4.55 24314;24296 nqo1;cyp1a1 NQO1_33055;CYP1A1_8415 62.51035 62.51035 24.1117 54.30389160681765 80.92608765884287 47.65116847052499 44.888999999999996 44.888999999999996 16.4151 40.268175553655276 58.544893436986094 35.33495594019271 98.21419999999999 98.21419999999999 37.0434 86.50857498121215 127.55130964269695 75.91048373515186 24.1117;100.909 16.4151;73.3629 37.0434;159.385 2 0 2 24314;24296 NQO1_33055;CYP1A1_8415 62.51035 62.51035 54.30389160681765 44.888999999999996 44.888999999999996 40.268175553655276 98.21419999999999 98.21419999999999 86.50857498121215 24.1117;100.909 16.4151;73.3629 37.0434;159.385 0 0 Exp 4,1(0.5);Poly 2,1(0.5) 3.0165958677594062 6.68002462387085 1.9061951637268066 4.773829460144043 2.027723656959742 3.340012311935425 -12.751003999999995 137.771704 -10.919843999999998 100.69784399999999 -21.68056799999998 218.108968 UP 1.0 0.0 0.0 GO:0006541 9 glutamine metabolic process 8 8 2 2 2 2 2 2 50 6 2489 0.99958 0.010583 0.010583 25.0 297417;25612 gfpt1;asns GFPT1_8705;ASNS_8091 568.2435 568.2435 154.987 584.4329470388368 374.0053702539932 515.8536299087627 304.2323 304.2323 53.5946 354.45523458199904 186.42798695993716 312.86227158431507 2351.5474999999997 2351.5474999999997 462.615 2671.353959907316 1463.7146019900497 2357.8883496754047 0.0 154.987 0.0 154.987 981.5;154.987 554.87;53.5946 4240.48;462.615 2 0 2 297417;25612 GFPT1_8705;ASNS_8091 568.2435 568.2435 584.4329470388368 304.2323 304.2323 354.45523458199904 2351.5474999999997 2351.5474999999997 2671.353959907316 981.5;154.987 554.87;53.5946 4240.48;462.615 0 0 Exp 4,1(0.5);Linear,1(0.5) 2.003110500890412 4.157394647598267 1.5232417583465576 2.634152889251709 0.785532793958649 2.0786973237991333 -241.73923999999988 1378.22624 -187.01759199999998 795.4821919999999 -1350.7601999999997 6053.855199999999 UP 1.0 0.0 0.0 GO:0045669 7 positive regulation of osteoblast differentiation 22 22 1 1 1 1 1 1 51 21 2474 0.92717 0.366 0.366 4.55 25695 cebpd CEBPD_8283 5.66035 5.66035 5.66035 5.66035 2.15795 2.15795 2.15795 2.15795 16.35 16.35 16.35 16.35 5.66035 2.15795 16.35 0 1 0 1 25695 CEBPD_8283 5.66035 5.66035 2.15795 2.15795 16.35 16.35 5.66035 2.15795 16.35 0 Exp 4,1(1) 1.577596664428711 1.577596664428711 1.577596664428711 1.577596664428711 0.0 1.577596664428711 5.66035 5.66035 2.15795 2.15795 16.35 16.35 DOWN 0.0 1.0 0.0 GO:0000082 6 G1/S transition of mitotic cell cycle 23 25 3 3 2 2 2 2 50 23 2472 0.98655 0.091027 0.091027 8.0 29200;58919 inhba;ccnd1 INHBA_33300;CCND1_8224 321.4505 321.4505 130.168 270.51430574463154 394.89039721695127 249.78221034738897 209.594 209.594 89.164 170.31373931659186 255.83119797596459 157.26097051291183 616.9449999999999 616.9449999999999 231.33 545.341962854501 764.9957938013914 503.54719874065006 0.5 321.4505 130.168;512.733 89.164;330.024 231.33;1002.56 0 2 0 2 29200;58919 INHBA_33300;CCND1_8224 321.4505 321.4505 270.51430574463154 209.594 209.594 170.31373931659186 616.9449999999999 616.9449999999999 545.341962854501 130.168;512.733 89.164;330.024 231.33;1002.56 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.5951023587155397 3.1912145614624023 1.555469274520874 1.6357452869415283 0.05676371274926017 1.5956072807312012 -53.46319999999997 696.3642 -26.448799999999977 445.6368 -138.8603999999998 1372.7503999999997 DOWN 0.0 1.0 0.0 GO:2000844 7 negative regulation of testosterone secretion 1 1 1 1 1 1 1 1 51 0 2495 1.0 0.020416 0.020416 100.0 24484 igfbp3 IGFBP3_8881 44.9033 44.9033 44.9033 44.9033 18.8755 18.8755 18.8755 18.8755 122.765 122.765 122.765 122.765 0.0 44.9033 0.0 44.9033 44.9033 18.8755 122.765 0 1 0 1 24484 IGFBP3_8881 44.9033 44.9033 18.8755 18.8755 122.765 122.765 44.9033 18.8755 122.765 0 Exp 4,1(1) 1.6548216342926025 1.6548216342926025 1.6548216342926025 1.6548216342926025 0.0 1.6548216342926025 44.9033 44.9033 18.8755 18.8755 122.765 122.765 DOWN 0.0 1.0 0.0 GO:0043010 7 camera-type eye development 12 12 2 2 2 2 2 2 50 10 2485 0.99845 0.023677 0.023677 16.67 308843;24296 tsku;cyp1a1 TSKU_10094;CYP1A1_8415 53.517630000000004 53.517630000000004 6.12626 67.02151819344142 69.51758165022301 63.08634555381103 37.414575 37.414575 1.46625 50.838608759595786 49.55120371333964 47.85361666123397 100.35945 100.35945 41.3339 83.47473333653123 120.28725428436276 78.5735091389793 0.0 6.12626 0.5 53.517630000000004 6.12626;100.909 1.46625;73.3629 41.3339;159.385 1 1 1 24296 CYP1A1_8415 100.909 100.909 73.3629 73.3629 159.385 159.385 100.909 73.3629 159.385 1 308843 TSKU_10094 6.12626 6.12626 1.46625 1.46625 41.3339 41.3339 6.12626 1.46625 41.3339 0 Hill,1(0.5);Poly 2,1(0.5) 2.1231925521172963 4.271087646484375 1.9061951637268066 2.3648924827575684 0.32434798479874083 2.1355438232421875 -39.36945519999998 146.4047152 -33.04414199999998 107.87329199999998 -15.330627999999976 216.04952799999995 CONFLICT 0.5 0.5 0.0 GO:0043269 6 regulation of ion transport 174 184 7 7 4 4 2 2 50 182 2313 0.26223 0.9001 0.5834 1.09 170698;24424 slco1a2;gstm2 SLCO1A2_9886;GSTM2_8759 222.13834000000003 222.13834000000003 3.28268 309.5086425741149 356.2678933897059 244.56926553233808 150.0795385 150.0795385 0.808077 211.10172532855327 241.56318788253674 166.80953878000545 392.81919999999997 392.81919999999997 13.1174 536.9794352174765 625.5261487499998 424.31340522473465 440.994;3.28268 299.351;0.808077 772.521;13.1174 1 1 1 24424 GSTM2_8759 3.28268 3.28268 0.808077 0.808077 13.1174 13.1174 3.28268 0.808077 13.1174 1 170698 SLCO1A2_9886 440.994 440.994 299.351 299.351 772.521 772.521 440.994 299.351 772.521 0 Exp 2,1(0.5);Hill,1(0.5) 1.689240446445377 3.378643751144409 1.672735333442688 1.7059084177017212 0.023456912832435096 1.6893218755722046 -206.81875359999992 651.0954336 -142.49252603999992 442.65160303999994 -351.39632799999987 1137.0347279999999 CONFLICT 0.5 0.5 0.0 GO:0045444 5 fat cell differentiation 31 34 4 4 2 4 2 2 50 32 2463 0.96923 0.15188 0.15188 5.88 25695;58919 cebpd;ccnd1 CEBPD_8283;CCND1_8224 259.19667499999997 259.19667499999997 5.66035 358.5545093692328 278.2362958357219 357.5420560799459 166.09097500000001 166.09097500000001 2.15795 231.83630727584762 178.40172628367867 231.1816692061982 509.455 509.455 16.35 697.355778673985 546.4853238882974 695.3866494803127 0.5 259.19667499999997 5.66035;512.733 2.15795;330.024 16.35;1002.56 0 2 0 2 25695;58919 CEBPD_8283;CCND1_8224 259.19667499999997 259.19667499999997 358.5545093692328 166.09097500000001 166.09097500000001 231.83630727584762 509.455 509.455 697.355778673985 5.66035;512.733 2.15795;330.024 16.35;1002.56 0 Exp 2,1(0.5);Exp 4,1(0.5) 1.5664939001175453 3.133065938949585 1.555469274520874 1.577596664428711 0.015646427453790256 1.5665329694747925 -237.73452199999997 756.1278719999999 -155.21775399999993 487.39970399999993 -457.03079999999994 1475.9407999999999 DOWN 0.0 1.0 0.0 GO:0051240 5 positive regulation of multicellular organismal process 484 516 26 25 14 18 11 11 41 505 1990 0.64265 0.49142 0.86191 2.13 360918;24614;316351;83619;24539;29200;25587;289388;24330;25695;58919 pf4;orm1;npas2;nfe2l2;lpl;inhba;id2;g0s2;egr1;cebpd;ccnd1 PF4_32963;ORM1_9400;NPAS2_9350;NFE2L2_9301;LPL_32544;INHBA_33300;ID2_8861;G0S2_32729;EGR1_8533;CEBPD_8283;CCND1_8224 164.58371636363634 56.9823 2.99674 250.53179917438288 232.35491166238518 298.49879047014366 96.01394672727271 16.0812 0.998544 151.180877071472 132.63418565728438 180.34528457831635 411.6472454545454 231.33 10.914 657.0860861078482 605.4006718346301 799.0835763664992 179.631;56.9823;134.458;6.6423;769.435;130.168;2.99674;3.45084;8.26335;5.66035;512.733 110.795;16.0812;56.7249;3.4063;444.211;89.164;0.998544;1.07374;1.51678;2.15795;330.024 426.677;262.985;320.448;13.4683;2183.16;231.33;10.914;14.3222;45.9052;16.35;1002.56 5 6 5 360918;24614;83619;25587;289388 PF4_32963;ORM1_9400;NFE2L2_9301;ID2_8861;G0S2_32729 49.940636 6.6423 76.00814421904195 26.4709568 3.4063 47.55084682815913 145.6733 14.3222 190.798622114574 179.631;56.9823;6.6423;2.99674;3.45084 110.795;16.0812;3.4063;0.998544;1.07374 426.677;262.985;13.4683;10.914;14.3222 6 316351;24539;29200;24330;25695;58919 NPAS2_9350;LPL_32544;INHBA_33300;EGR1_8533;CEBPD_8283;CCND1_8224 260.1196166666667 132.313 311.1511025750875 153.96643833333334 72.94445 187.1791435200344 633.2922 275.889 839.468304965232 134.458;769.435;130.168;8.26335;5.66035;512.733 56.7249;444.211;89.164;1.51678;2.15795;330.024 320.448;2183.16;231.33;45.9052;16.35;1002.56 0 Exp 2,2(0.19);Exp 4,4(0.37);Hill,3(0.28);Poly 2,2(0.19) 1.914700139513683 22.682905316352844 1.5423688888549805 5.289852619171143 1.0865686527665923 1.6902254819869995 16.52888429166967 312.638548435603 6.671757667553095 185.35613578699235 23.334183176139163 799.9603077329517 CONFLICT 0.45454545454545453 0.5454545454545454 0.0 GO:0001656 6 metanephros development 10 10 2 2 2 2 2 2 50 8 2487 0.99913 0.01657 0.01657 20.0 25587;24330 id2;egr1 ID2_8861;EGR1_8533 5.630045000000001 5.630045000000001 2.99674 3.724055644864883 6.767068748219881 3.3590094429783965 1.257662 1.257662 0.998544 0.3664481898549911 1.3695454770720592 0.3305275343515759 28.4096 28.4096 10.914 24.742514801854718 35.9639519225292 22.31715870762133 0.0 2.99674 0.0 2.99674 2.99674;8.26335 0.998544;1.51678 10.914;45.9052 1 1 1 25587 ID2_8861 2.99674 2.99674 0.998544 0.998544 10.914 10.914 2.99674 0.998544 10.914 1 24330 EGR1_8533 8.26335 8.26335 1.51678 1.51678 45.9052 45.9052 8.26335 1.51678 45.9052 0 Hill,2(1) 3.234489523986614 7.267586827278137 1.9777342081069946 5.289852619171143 2.342021388556272 3.6337934136390686 0.4687672000000003 10.791322800000001 0.7497907200000001 1.76553328 -5.881775999999995 62.70097599999999 CONFLICT 0.5 0.5 0.0 GO:0035690 5 cellular response to drug 160 174 11 11 8 8 6 6 46 168 2327 0.93948 0.14021 0.16448 3.45 286954;170698;24314;83619;24424;24330 ugt2b1;slco1a2;nqo1;nfe2l2;gstm2;egr1 UGT2B10_33303,UGT2B1_33224;SLCO1A2_9886;NQO1_33055;NFE2L2_9301;GSTM2_8759;EGR1_8533 84.79843833333334 16.187525 3.28268 174.74878365946478 101.25596257997556 187.65988626679453 55.472742833333335 7.37275 0.808077 119.63298831896452 66.37584172064487 128.68295103589261 157.672175 41.4743 13.1174 301.8449010597756 188.27102358673335 322.8743413587723 25.4966;440.994;24.1117;6.6423;3.28268;8.26335 11.3392;299.351;16.4151;3.4063;0.808077;1.51678 63.97775;772.521;37.0434;13.4683;13.1174;45.9052 5 2 4 286954;24314;83619;24424 UGT2B10_33303,UGT2B1_33224;NQO1_33055;NFE2L2_9301;GSTM2_8759 14.88332 15.376999999999999 11.551247679115301 7.99216925 7.37275 7.183076302331444 31.9017125 25.25585 24.138145638124143 25.4966;24.1117;6.6423;3.28268 11.3392;16.4151;3.4063;0.808077 63.97775;37.0434;13.4683;13.1174 2 170698;24330 SLCO1A2_9886;EGR1_8533 224.62867500000002 224.62867500000002 305.9867770422625 150.43389 150.43389 210.60059663140606 409.2131 409.2131 513.7949594972881 440.994;8.26335 299.351;1.51678 772.521;45.9052 0 Exp 2,1(0.15);Exp 4,4(0.58);Hill,2(0.29) 2.281173248441338 18.385982632637024 1.5423688888549805 5.289852619171143 1.650827757251717 1.7026138305664062 -55.02971035831389 224.6265870249806 -40.253584576695786 151.19907024336243 -83.85404809205909 399.1983980920591 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0033993 5 response to lipid 414 443 34 32 19 28 17 17 35 426 2069 0.99808 0.0050286 0.0082242 3.84 286954;170698;360918;24614;24314;25333;59107;24539;29200;24484;116686;25315;24330;24296;58919;24188;140668 ugt2b1;slco1a2;pf4;orm1;nqo1;mgp;ltbp1;lpl;inhba;igfbp3;gsr;ephx1;egr1;cyp1a1;ccnd1;aldh1a1;abcc3 UGT2B10_33303,UGT2B1_33224;SLCO1A2_9886;PF4_32963;ORM1_9400;NQO1_33055;MGP_33209;LTBP1_33264;LPL_32544;INHBA_33300;IGFBP3_8881;GSR_8755;EPHX1_8567;EGR1_8533;CYP1A1_8415;CCND1_8224;ALDH1A1_8022;ABCC3_7941 214.23624411764706 86.4919 8.26335 291.5266870576249 237.2615076411721 315.2781828261178 124.19910470588235 57.2867 1.51678 163.38976193917455 134.16416124082653 176.14150723286477 653.5314029411765 159.385 37.0434 1257.132988023827 759.251846983849 1362.388106478147 25.4966;440.994;179.631;56.9823;24.1117;75.1005;998.777;769.435;130.168;44.9033;74.6342;24.8784;8.26335;100.909;512.733;88.5069;86.4919 11.3392;299.351;110.795;16.0812;16.4151;13.9312;507.146;444.211;89.164;18.8755;57.2867;15.4867;1.51678;73.3629;330.024;65.9487;40.4498 63.97775;772.521;426.677;262.985;37.0434;346.231;5065.92;2183.16;231.33;122.765;106.529;41.3795;45.9052;159.385;1002.56;133.645;108.02 10 8 9 286954;360918;24614;24314;116686;25315;24296;24188;140668 UGT2B10_33303,UGT2B1_33224;PF4_32963;ORM1_9400;NQO1_33055;GSR_8755;EPHX1_8567;CYP1A1_8415;ALDH1A1_8022;ABCC3_7941 73.51577777777777 74.6342 49.73774737650918 45.24058888888889 40.4498 34.27992918219219 148.84907222222222 108.02 125.13437643745502 25.4966;179.631;56.9823;24.1117;74.6342;24.8784;100.909;88.5069;86.4919 11.3392;110.795;16.0812;16.4151;57.2867;15.4867;73.3629;65.9487;40.4498 63.97775;426.677;262.985;37.0434;106.529;41.3795;159.385;133.645;108.02 8 170698;25333;59107;24539;29200;24484;24330;58919 SLCO1A2_9886;MGP_33209;LTBP1_33264;LPL_32544;INHBA_33300;IGFBP3_8881;EGR1_8533;CCND1_8224 372.54676875 285.581 370.57796088558644 213.027435 194.2575 206.50310183205642 1221.299025 559.376 1702.5042823603133 440.994;75.1005;998.777;769.435;130.168;44.9033;8.26335;512.733 299.351;13.9312;507.146;444.211;89.164;18.8755;1.51678;330.024 772.521;346.231;5065.92;2183.16;231.33;122.765;45.9052;1002.56 0 Exp 2,4(0.23);Exp 4,6(0.34);Exp 5,1(0.06);Hill,2(0.12);Poly 2,5(0.28) 2.1263923522938724 41.452287554740906 1.555469274520874 5.289852619171143 1.110019013662128 1.7812026739120483 75.6532538874738 352.8192343478203 46.5285421544299 201.86966725733487 55.928314333039 1251.134491549314 CONFLICT 0.5294117647058824 0.47058823529411764 0.0 GO:0045648 6 positive regulation of erythrocyte differentiation 15 16 4 4 2 3 2 2 50 14 2481 0.99627 0.040873 0.040873 12.5 29200;25587 inhba;id2 INHBA_33300;ID2_8861 66.58237 66.58237 2.99674 89.92366031803756 78.57014283099451 88.31110513462471 45.081272 45.081272 0.998544 62.34239180400419 53.39217068944478 61.22443745590104 121.122 121.122 10.914 155.85764828201408 141.8994691885296 153.06273248651814 0.0 2.99674 0.5 66.58237 130.168;2.99674 89.164;0.998544 231.33;10.914 1 1 1 25587 ID2_8861 2.99674 2.99674 0.998544 0.998544 10.914 10.914 2.99674 0.998544 10.914 1 29200 INHBA_33300 130.168 130.168 89.164 89.164 231.33 231.33 130.168 89.164 231.33 0 Hill,1(0.5);Poly 2,1(0.5) 1.7986298701328332 3.613479495048523 1.6357452869415283 1.9777342081069946 0.24182268524677283 1.8067397475242615 -58.04546479999999 191.21020479999999 -41.32087487999999 131.48341888 -94.88568000000002 337.12968 CONFLICT 0.5 0.5 0.0 GO:0006725 4 cellular aromatic compound metabolic process 429 482 31 28 15 22 11 11 41 471 2024 0.73115 0.39385 0.71997 2.28 286954;266730;307126;24424;297417;25315;24330;24296;64392;24763;296925 ugt2b1;slc17a3;mcm10;gstm2;gfpt1;ephx1;egr1;cyp1a1;aldh1l1;acsm3;aass UGT2B10_33303,UGT2B1_33224;SLC17A3_9840;MCM10_32579;GSTM2_8759;GFPT1_8705;EPHX1_8567;EGR1_8533;CYP1A1_8415;ALDH1L1_32662;ACSM3_7976;AASS_7936 189.94774818181816 58.7587 3.28268 295.5453929778787 135.9388161569751 181.40074487730718 116.02968881818182 46.6655 0.808077 174.7503641753938 86.65092762837169 116.20733909927432 667.0948318181818 128.079 13.1174 1243.8697378542251 379.97877107105415 663.4312498849015 25.4966;58.7587;213.608;3.28268;981.5;24.8784;8.26335;100.909;184.03;460.125;28.5735 11.3392;46.6655;123.177;0.808077;554.87;15.4867;1.51678;73.3629;111.154;331.8;6.14642 63.97775;78.8953;668.095;13.1174;4240.48;41.3795;45.9052;159.385;1150.07;748.659;128.079 8 4 7 286954;266730;24424;297417;25315;24296;64392 UGT2B10_33303,UGT2B1_33224;SLC17A3_9840;GSTM2_8759;GFPT1_8705;EPHX1_8567;CYP1A1_8415;ALDH1L1_32662 196.97934 58.7587 351.31141614550074 116.240911 46.6655 197.30734704763634 821.0435642857143 78.8953 1561.150719949883 25.4966;58.7587;3.28268;981.5;24.8784;100.909;184.03 11.3392;46.6655;0.808077;554.87;15.4867;73.3629;111.154 63.97775;78.8953;13.1174;4240.48;41.3795;159.385;1150.07 4 307126;24330;24763;296925 MCM10_32579;EGR1_8533;ACSM3_7976;AASS_7936 177.6424625 121.09075 209.76236015406965 115.66005000000001 64.66171 154.6985280746338 397.68455 398.087 361.819816897504 213.608;8.26335;460.125;28.5735 123.177;1.51678;331.8;6.14642 668.095;45.9052;748.659;128.079 0 Exp 4,3(0.25);Hill,3(0.25);Linear,2(0.17);Poly 2,4(0.34) 1.973269367087351 25.362303376197815 1.5232417583465576 5.289852619171143 1.0434197676248704 1.733633041381836 15.2915820935917 364.6039142700446 12.758822972947215 219.30055466341645 -67.98520897625303 1402.1748726126166 UP 0.6363636363636364 0.36363636363636365 0.0 GO:0051179 2 localization 693 737 23 21 9 16 8 8 44 729 1766 0.01741 0.99313 0.030092 1.09 170698;266730;59107;29200;25598;58919;114628;140668 slco1a2;slc17a3;ltbp1;inhba;fabp2;ccnd1;abcg5;abcc3 SLCO1A2_9886;SLC17A3_9840;LTBP1_33264;INHBA_33300;FABP2_32859;CCND1_8224;ABCG5_7947;ABCC3_7941 341.94195 253.80650000000003 58.7587 316.0496684654577 360.9502816754034 333.557455910208 210.2876125 184.75029999999998 40.4498 168.09502188330808 219.18981995044643 175.8173992071942 1013.4211625 424.0615 78.8953 1669.1398692675423 1121.330326879761 1797.2133176581115 440.994;58.7587;998.777;130.168;146.645;512.733;360.968;86.4919 299.351;46.6655;507.146;89.164;95.8536;330.024;273.647;40.4498 772.521;78.8953;5065.92;231.33;319.535;1002.56;528.588;108.02 3 5 3 266730;25598;140668 SLC17A3_9840;FABP2_32859;ABCC3_7941 97.29853333333334 86.4919 44.928698233126376 60.98963333333334 46.6655 30.352608791063272 168.81676666666667 108.02 131.33564417881132 58.7587;146.645;86.4919 46.6655;95.8536;40.4498 78.8953;319.535;108.02 5 170698;59107;29200;58919;114628 SLCO1A2_9886;LTBP1_33264;INHBA_33300;CCND1_8224;ABCG5_7947 488.72800000000007 440.994 319.33236931996095 299.8664 299.351 149.12875087755543 1520.1838 772.521 2002.7222479148727 440.994;998.777;130.168;512.733;360.968 299.351;507.146;89.164;330.024;273.647 772.521;5065.92;231.33;1002.56;528.588 0 Exp 2,3(0.38);Exp 5,1(0.13);Linear,1(0.13);Poly 2,3(0.38) 1.9270132675109723 15.912368297576904 1.555469274520874 3.368933916091919 0.5989298133767014 1.7340298295021057 122.93070351158849 560.9531964884115 93.80370523975952 326.7715197602405 -143.23375540174834 2170.076080401748 DOWN 0.375 0.625 0.0 GO:0032502 2 developmental process 992 1073 56 53 28 43 22 22 30 1051 1444 0.56951 0.54303 1.0 2.05 24522;308843;24614;338475;24314;83619;25333;59107;29200;24484;494344;25587;24424;116686;25315;24330;24296;29276;25695;58919;25612;24188 zfp354a;tsku;orm1;nrep;nqo1;nfe2l2;mgp;ltbp1;inhba;igfbp3;ier2;id2;gstm2;gsr;ephx1;egr1;cyp1a1;csrp1;cebpd;ccnd1;asns;aldh1a1 ZFP354A_10203;TSKU_10094;ORM1_9400;NREP_9364;NQO1_33055;NFE2L2_9301;MGP_33209;LTBP1_33264;INHBA_33300;IGFBP3_8881;IER2_32643;ID2_8861;GSTM2_8759;GSR_8755;EPHX1_8567;EGR1_8533;CYP1A1_8415;CSRP1_8396;CEBPD_8283;CCND1_8224;ASNS_8091;ALDH1A1_8022 152.381505 65.80825 2.99674 246.3009275260428 166.73154890824617 264.22757621592285 90.39428504545455 17.6453 0.808077 142.89652675214438 96.29676619619865 148.7524693422185 449.75340454545454 128.205 6.6682 1071.5275874576478 536.9565252493908 1218.5958424844323 3.26713;6.12626;56.9823;112.624;24.1117;6.6423;75.1005;998.777;130.168;44.9033;543.54;2.99674;3.28268;74.6342;24.8784;8.26335;100.909;373.299;5.66035;512.733;154.987;88.5069 1.71987;1.46625;16.0812;79.4619;16.4151;3.4063;13.9312;507.146;89.164;18.8755;375.947;0.998544;0.808077;57.2867;15.4867;1.51678;73.3629;263.875;2.15795;330.024;53.5946;65.9487 6.6682;41.3339;262.985;192.339;37.0434;13.4683;346.231;5065.92;231.33;122.765;978.946;10.914;13.1174;106.529;41.3795;45.9052;159.385;603.145;16.35;1002.56;462.615;133.645 10 12 10 24614;24314;83619;25587;24424;116686;25315;24296;25612;24188 ORM1_9400;NQO1_33055;NFE2L2_9301;ID2_8861;GSTM2_8759;GSR_8755;EPHX1_8567;CYP1A1_8415;ASNS_8091;ALDH1A1_8022 53.793122 40.930350000000004 50.75157340398552 30.3388821 16.24815 28.794611648634042 124.10816 73.95425 144.26651260874553 56.9823;24.1117;6.6423;2.99674;3.28268;74.6342;24.8784;100.909;154.987;88.5069 16.0812;16.4151;3.4063;0.998544;0.808077;57.2867;15.4867;73.3629;53.5946;65.9487 262.985;37.0434;13.4683;10.914;13.1174;106.529;41.3795;159.385;462.615;133.645 12 24522;308843;338475;25333;59107;29200;24484;494344;24330;29276;25695;58919 ZFP354A_10203;TSKU_10094;NREP_9364;MGP_33209;LTBP1_33264;INHBA_33300;IGFBP3_8881;IER2_32643;EGR1_8533;CSRP1_8396;CEBPD_8283;CCND1_8224 234.53849083333333 93.86224999999999 312.2603297071471 140.44045416666668 49.1687 179.70269761228988 721.1244416666667 211.8345 1413.5747146857132 3.26713;6.12626;112.624;75.1005;998.777;130.168;44.9033;543.54;8.26335;373.299;5.66035;512.733 1.71987;1.46625;79.4619;13.9312;507.146;89.164;18.8755;375.947;1.51678;263.875;2.15795;330.024 6.6682;41.3339;192.339;346.231;5065.92;231.33;122.765;978.946;45.9052;603.145;16.35;1002.56 0 Exp 2,3(0.14);Exp 4,8(0.37);Hill,5(0.23);Linear,1(0.05);Poly 2,5(0.23) 2.1752282598688457 52.965930342674255 1.5423688888549805 6.495501518249512 1.3476174364913656 1.8661195635795593 49.458897992296926 255.30411200770308 30.681626983614315 150.10694310729477 1.9905240335462508 897.5162850573627 CONFLICT 0.45454545454545453 0.5454545454545454 0.0 GO:0042737 5 drug catabolic process 55 60 7 7 3 7 3 3 49 57 2438 0.96753 0.12208 0.12208 5.0 499353;29277;296925 cyp2c24;cyp2c11;aass CYP2C24_32875;CYP2C11_32593;AASS_7936 297.4808333333333 129.934 28.5735 381.3629077933292 382.48916129032256 421.07884552019294 171.55434 45.3106 6.14642 253.33569889444087 232.80102317996906 275.42051358301984 748.9906666666666 355.143 128.079 886.1105424631475 947.9727654271471 977.1733900772169 2.0 733.935 733.935;129.934;28.5735 463.206;45.3106;6.14642 1763.75;355.143;128.079 0 3 0 3 499353;29277;296925 CYP2C24_32875;CYP2C11_32593;AASS_7936 297.4808333333333 129.934 381.3629077933292 171.55434 45.3106 253.33569889444087 748.9906666666666 355.143 886.1105424631475 733.935;129.934;28.5735 463.206;45.3106;6.14642 1763.75;355.143;128.079 0 Exp 4,1(0.34);Hill,1(0.34);Linear,1(0.34) 1.6498877590454126 4.951007008552551 1.6175053119659424 1.7045893669128418 0.04732998810526212 1.628912329673767 -134.07192251456416 729.0335891812308 -115.12199054601291 458.23067054601296 -253.7378073701459 1751.719140703479 DOWN 0.0 1.0 0.0 GO:0032501 2 multicellular organismal process 609 640 32 29 14 25 11 11 41 629 1866 0.31357 0.79407 0.62817 1.72 316351;25333;24539;29200;24484;25587;24424;297417;25598;24330;114628 npas2;mgp;lpl;inhba;igfbp3;id2;gstm2;gfpt1;fabp2;egr1;abcg5 NPAS2_9350;MGP_33209;LPL_32544;INHBA_33300;IGFBP3_8881;ID2_8861;GSTM2_8759;GFPT1_8705;FABP2_32859;EGR1_8533;ABCG5_7947 241.6109609090909 130.168 2.99674 332.83746699544145 232.8845109032258 282.659846542276 140.963691 56.7249 0.808077 195.55525699633034 135.59202587279927 173.38683687161026 760.2248727272727 319.535 10.914 1306.3518586843138 619.6797878161867 880.2533034085686 134.458;75.1005;769.435;130.168;44.9033;2.99674;3.28268;981.5;146.645;8.26335;360.968 56.7249;13.9312;444.211;89.164;18.8755;0.998544;0.808077;554.87;95.8536;1.51678;273.647 320.448;346.231;2183.16;231.33;122.765;10.914;13.1174;4240.48;319.535;45.9052;528.588 4 7 4 25587;24424;297417;25598 ID2_8861;GSTM2_8759;GFPT1_8705;FABP2_32859 283.606105 74.96384 470.15496427260587 163.13255525 48.426072 264.96626029360834 1146.0115999999998 166.3262 2068.0662528769494 2.99674;3.28268;981.5;146.645 0.998544;0.808077;554.87;95.8536 10.914;13.1174;4240.48;319.535 7 316351;25333;24539;29200;24484;24330;114628 NPAS2_9350;MGP_33209;LPL_32544;INHBA_33300;IGFBP3_8881;EGR1_8533;ABCG5_7947 217.6137357142857 130.168 268.8200410561787 128.29576857142857 56.7249 167.68425692748335 539.7753142857143 320.448 741.5463637489058 134.458;75.1005;769.435;130.168;44.9033;8.26335;360.968 56.7249;13.9312;444.211;89.164;18.8755;1.51678;273.647 320.448;346.231;2183.16;231.33;122.765;45.9052;528.588 0 Exp 2,1(0.1);Exp 4,1(0.1);Hill,5(0.46);Linear,2(0.19);Poly 2,2(0.19) 2.0073842245009534 23.6267306804657 1.5232417583465576 5.289852619171143 1.0624701590091485 1.8888624906539917 44.91658739777185 438.30533442040996 25.397919186621195 256.5294628133788 -11.779741863720915 1532.2294873182664 DOWN 0.36363636363636365 0.6363636363636364 0.0 GO:0060416 6 response to growth hormone 18 18 4 4 4 3 3 3 49 15 2480 0.99962 0.0052762 0.0052762 16.67 286954;24614;24484 ugt2b1;orm1;igfbp3 UGT2B10_33303,UGT2B1_33224;ORM1_9400;IGFBP3_8881 42.46073333333334 44.9033 25.4966 15.884329544029647 46.17679261696388 13.841363043346947 15.431966666666668 16.0812 11.3392 3.80986644954035 16.33801910903468 3.3128992190932536 149.90925000000001 122.765 63.97775 102.24274604678561 168.60112935118775 98.80391839462581 0.0 25.4966 0.5 35.19995 25.4966;56.9823;44.9033 11.3392;16.0812;18.8755 63.97775;262.985;122.765 3 1 2 286954;24614 UGT2B10_33303,UGT2B1_33224;ORM1_9400 41.239450000000005 41.239450000000005 22.263751980405264 13.7102 13.7102 3.3531003563866033 163.481375 163.481375 140.71937598028657 25.4966;56.9823 11.3392;16.0812 63.97775;262.985 1 24484 IGFBP3_8881 44.9033 44.9033 18.8755 18.8755 122.765 122.765 44.9033 18.8755 122.765 0 Exp 4,4(1) 1.6595119051468776 6.6407986879348755 1.5846891403198242 1.7026138305664062 0.05480269097445839 1.6767478585243225 24.485922334574532 60.43554433209214 11.120696923038103 19.74323641029523 34.21069117251548 265.6078088274845 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0017144 4 drug metabolic process 142 165 18 17 10 15 8 8 44 157 2338 0.99471 0.016973 0.016973 4.85 286954;246248;499353;29277;24296;25612;24188;296925 ugt2b1;fmo5;cyp2c24;cyp2c11;cyp1a1;asns;aldh1a1;aass UGT2B10_33303,UGT2B1_33224;FMO5_33281;CYP2C24_32875;CYP2C11_32593;CYP1A1_8415;ASNS_8091;ALDH1A1_8022;AASS_7936 164.97997499999997 94.70795000000001 25.4966 234.40071845613167 204.71920133829 280.74886640302935 93.807165 49.452600000000004 6.14642 151.17633581331845 125.79634728418645 179.26228185027446 396.95259375 146.515 63.97775 568.9628375206996 477.2784029539606 683.236623195718 25.4966;57.4978;733.935;129.934;100.909;154.987;88.5069;28.5735 11.3392;31.5489;463.206;45.3106;73.3629;53.5946;65.9487;6.14642 63.97775;109.026;1763.75;355.143;159.385;462.615;133.645;128.079 6 3 5 286954;246248;24296;25612;24188 UGT2B10_33303,UGT2B1_33224;FMO5_33281;CYP1A1_8415;ASNS_8091;ALDH1A1_8022 85.47945999999999 88.5069 48.62985452515771 47.15886 53.5946 25.533543832633185 185.72975000000002 133.645 158.72879659245038 25.4966;57.4978;100.909;154.987;88.5069 11.3392;31.5489;73.3629;53.5946;65.9487 63.97775;109.026;159.385;462.615;133.645 3 499353;29277;296925 CYP2C24_32875;CYP2C11_32593;AASS_7936 297.4808333333333 129.934 381.3629077933292 171.55434 45.3106 253.33569889444087 748.9906666666666 355.143 886.1105424631475 733.935;129.934;28.5735 463.206;45.3106;6.14642 1763.75;355.143;128.079 0 Exp 4,4(0.45);Exp 5,1(0.12);Hill,1(0.12);Linear,1(0.12);Poly 2,2(0.23) 1.889463148179871 17.373021483421326 1.6175053119659424 2.79919695854187 0.45526691894742743 1.7026138305664062 2.548564215377155 327.4113857846228 -10.952690964361537 198.56702096436157 2.681462709054074 791.2237247909461 UP 0.625 0.375 0.0 GO:0072301 8 regulation of metanephric glomerular mesangial cell proliferation 1 1 1 1 1 1 1 1 51 0 2495 1.0 0.020416 0.020416 100.0 24330 egr1 EGR1_8533 8.26335 8.26335 8.26335 8.26335 1.51678 1.51678 1.51678 1.51678 45.9052 45.9052 45.9052 45.9052 0.0 8.26335 0.0 8.26335 8.26335 1.51678 45.9052 0 1 0 1 24330 EGR1_8533 8.26335 8.26335 1.51678 1.51678 45.9052 45.9052 8.26335 1.51678 45.9052 0 Hill,1(1) 5.289852619171143 5.289852619171143 5.289852619171143 5.289852619171143 0.0 5.289852619171143 8.26335 8.26335 1.51678 1.51678 45.9052 45.9052 DOWN 0.0 1.0 0.0 GO:0072303 8 positive regulation of glomerular metanephric mesangial cell proliferation 1 1 1 1 1 1 1 1 51 0 2495 1.0 0.020416 0.020416 100.0 24330 egr1 EGR1_8533 8.26335 8.26335 8.26335 8.26335 1.51678 1.51678 1.51678 1.51678 45.9052 45.9052 45.9052 45.9052 0.0 8.26335 0.0 8.26335 8.26335 1.51678 45.9052 0 1 0 1 24330 EGR1_8533 8.26335 8.26335 1.51678 1.51678 45.9052 45.9052 8.26335 1.51678 45.9052 0 Hill,1(1) 5.289852619171143 5.289852619171143 5.289852619171143 5.289852619171143 0.0 5.289852619171143 8.26335 8.26335 1.51678 1.51678 45.9052 45.9052 DOWN 0.0 1.0 0.0 GO:1903320 8 regulation of protein modification by small protein conjugation or removal 63 67 8 5 3 4 3 3 49 64 2431 0.954 0.15511 0.15511 4.48 246273;363140;24330 trib3;rassf1;egr1 TRIB3_10079;RASSF1_32475;EGR1_8533 260.57975 16.8949 8.26335 429.571363006221 434.2438805718132 452.37284483456335 148.49382333333332 6.46469 1.51678 250.2989174306502 249.68945460962192 263.575975800036 348.36103333333335 58.9909 45.9052 512.5780818585821 555.3586373288072 540.0825019401188 16.8949;756.581;8.26335 6.46469;437.5;1.51678 58.9909;940.187;45.9052 2 1 2 246273;363140 TRIB3_10079;RASSF1_32475 386.73795 386.73795 523.0370572594306 221.982345 221.982345 304.7879906318457 499.58895 499.58895 623.099737865139 16.8949;756.581 6.46469;437.5 58.9909;940.187 1 24330 EGR1_8533 8.26335 8.26335 1.51678 1.51678 45.9052 45.9052 8.26335 1.51678 45.9052 0 Exp 4,1(0.34);Hill,1(0.34);Poly 2,1(0.34) 2.9755262672929583 9.7537522315979 2.1946890354156494 5.289852619171143 1.7658741658280115 2.2692105770111084 -225.5260084528805 746.6855084528804 -134.74606548532395 431.73371215199063 -231.67567000850522 928.3977366751719 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0000122 9 negative regulation of transcription by RNA polymerase II 174 180 15 13 6 10 5 5 47 175 2320 0.84276 0.30469 0.41182 2.78 24522;246273;25587;24330;58919 zfp354a;trib3;id2;egr1;ccnd1 ZFP354A_10203;TRIB3_10079;ID2_8861;EGR1_8533;CCND1_8224 108.83102399999999 8.26335 2.99674 225.85811118534912 149.21477731653934 254.55434090136637 68.1447768 1.71987 0.998544 146.41152228538252 94.57568090550167 164.85588594824023 225.00766 45.9052 6.6682 435.23990863192677 301.330894927474 491.38535105582463 3.26713;16.8949;2.99674;8.26335;512.733 1.71987;6.46469;0.998544;1.51678;330.024 6.6682;58.9909;10.914;45.9052;1002.56 2 3 2 246273;25587 TRIB3_10079;ID2_8861 9.94582 9.94582 9.827483182015628 3.731617 3.731617 3.865148903555722 34.95245 34.95245 33.995502008427536 16.8949;2.99674 6.46469;0.998544 58.9909;10.914 3 24522;24330;58919 ZFP354A_10203;EGR1_8533;CCND1_8224 174.75449333333333 8.26335 292.7086329100059 111.08688333333333 1.71987 189.60513205639302 351.7111333333333 45.9052 563.9929706771294 3.26713;8.26335;512.733 1.71987;1.51678;330.024 6.6682;45.9052;1002.56 0 Exp 2,1(0.2);Exp 4,2(0.4);Hill,2(0.4) 2.992210099568339 17.58776819705963 1.555469274520874 6.495501518249512 2.2242075319171124 2.2692105770111084 -89.14233923301732 306.80438723301734 -60.19058087558153 196.4801344755815 -156.49694071094 606.5122607109399 DOWN 0.4 0.6 0.0 GO:0090092 6 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 55 58 3 3 3 3 3 3 49 55 2440 0.9709 0.11318 0.11318 5.17 338475;59107;29200 nrep;ltbp1;inhba NREP_9364;LTBP1_33264;INHBA_33300 413.85633333333334 130.168 112.624 506.63210291525485 522.3165115065393 537.2185247962575 225.2573 89.164 79.4619 244.1709689477232 277.41870619341046 259.02995352790333 1829.863 231.33 192.339 2802.5753789964333 2434.963817467304 2966.213245084079 1.5 564.4725000000001 112.624;998.777;130.168 79.4619;507.146;89.164 192.339;5065.92;231.33 0 3 0 3 338475;59107;29200 NREP_9364;LTBP1_33264;INHBA_33300 413.85633333333334 130.168 506.63210291525485 225.2573 89.164 244.1709689477232 1829.863 231.33 2802.5753789964333 112.624;998.777;130.168 79.4619;507.146;89.164 192.339;5065.92;231.33 0 Exp 2,1(0.34);Poly 2,2(0.67) 1.6992825358284789 5.1045331954956055 1.6357452869415283 1.826043963432312 0.10790540935090215 1.6427439451217651 -159.4518614231946 987.1645280898614 -51.04816231450906 501.56276231450903 -1341.5495929961048 5001.275592996104 DOWN 0.0 1.0 0.0 GO:0008299 5 isoprenoid biosynthetic process 14 14 4 4 3 4 3 3 49 11 2484 0.99987 0.0024934 0.0024934 21.43 305291;24296;24188 srd5a3;cyp1a1;aldh1a1 SRD5A3_9939;CYP1A1_8415;ALDH1A1_8022 119.54163333333334 100.909 88.5069 43.4578934694646 116.29529882247994 40.55482501814253 81.61953333333334 73.3629 65.9487 21.050779943349678 80.17029674843889 19.579147654857863 250.74699999999999 159.385 133.645 180.99327714586528 235.02467948260482 170.24017122518455 0.0 88.5069 0.5 94.70795000000001 169.209;100.909;88.5069 105.547;73.3629;65.9487 459.211;159.385;133.645 3 0 3 305291;24296;24188 SRD5A3_9939;CYP1A1_8415;ALDH1A1_8022 119.54163333333334 100.909 43.4578934694646 81.61953333333334 73.3629 21.050779943349678 250.74699999999999 159.385 180.99327714586528 169.209;100.909;88.5069 105.547;73.3629;65.9487 459.211;159.385;133.645 0 0 Poly 2,3(1) 2.014484371630507 6.2375054359436035 1.5321133136749268 2.79919695854187 0.6510108036956146 1.9061951637268066 70.36439740703479 168.7188692596319 57.79833333812209 105.44073332854458 45.933826127911374 455.5601738720886 UP 1.0 0.0 0.0 GO:0071407 6 cellular response to organic cyclic compound 197 209 18 17 11 13 9 9 43 200 2295 0.99177 0.023255 0.03437 4.31 286954;24614;59107;29200;24484;24424;25315;24330;24296 ugt2b1;orm1;ltbp1;inhba;igfbp3;gstm2;ephx1;egr1;cyp1a1 UGT2B10_33303,UGT2B1_33224;ORM1_9400;LTBP1_33264;INHBA_33300;IGFBP3_8881;GSTM2_8759;EPHX1_8567;EGR1_8533;CYP1A1_8415 154.85118111111112 44.9033 3.28268 319.2732361970601 193.55311558312852 352.12351349187986 81.53115077777778 16.0812 0.808077 162.66902779159352 100.54426329554721 179.2908724914223 667.4183166666667 122.765 13.1174 1651.732228346222 856.1312959563506 1833.158543500733 25.4966;56.9823;998.777;130.168;44.9033;3.28268;24.8784;8.26335;100.909 11.3392;16.0812;507.146;89.164;18.8755;0.808077;15.4867;1.51678;73.3629 63.97775;262.985;5065.92;231.33;122.765;13.1174;41.3795;45.9052;159.385 6 4 5 286954;24614;24424;25315;24296 UGT2B10_33303,UGT2B1_33224;ORM1_9400;GSTM2_8759;EPHX1_8567;CYP1A1_8415 42.309796000000006 25.4966 37.94338543338061 23.4156154 15.4867 28.584668919782608 108.16893 63.97775 102.51778267860166 25.4966;56.9823;3.28268;24.8784;100.909 11.3392;16.0812;0.808077;15.4867;73.3629 63.97775;262.985;13.1174;41.3795;159.385 4 59107;29200;24484;24330 LTBP1_33264;INHBA_33300;IGFBP3_8881;EGR1_8533 295.5279125 87.53565 471.6060520500424 154.17557 54.01975 238.34529839046462 1366.4800500000001 177.0475 2467.466084854395 998.777;130.168;44.9033;8.26335 507.146;89.164;18.8755;1.51678 5065.92;231.33;122.765;45.9052 0 Exp 2,1(0.1);Exp 4,5(0.5);Hill,2(0.2);Poly 2,2(0.2) 1.9796508436095186 21.45825731754303 1.5846891403198242 5.289852619171143 1.1471091334231944 1.7006439566612244 -53.74066653763481 363.44302875985704 -24.74594737939664 187.8082489349522 -411.71340585286487 1746.5500391861983 CONFLICT 0.5555555555555556 0.4444444444444444 0.0 GO:0071704 3 organic substance metabolic process 1263 1393 80 76 38 61 30 30 22 1363 1132 0.71784 0.38434 0.67606 2.15 286954;246273;24902;305291;266730;299270;501907;83619;307126;24539;29200;24484;24424;300850;116686;297417;25598;25315;24330;499353;29277;24296;290277;58919;25612;64392;24188;26760;24763;296925 ugt2b1;trib3;sult2a6;srd5a3;slc17a3;serpina6;rgd1559459;nfe2l2;mcm10;lpl;inhba;igfbp3;gstm2;gsta4;gsr;gfpt1;fabp2;ephx1;egr1;cyp2c24;cyp2c11;cyp1a1;cryl1;ccnd1;asns;aldh1l1;aldh1a1;akr7a3;acsm3;aass UGT2B10_33303,UGT2B1_33224;TRIB3_10079;SULT2A6_32471,SULT2A6_9972;SRD5A3_9939;SLC17A3_9840;SERPINA6_32325;RGD1559459_9690;NFE2L2_9301;MCM10_32579;LPL_32544;INHBA_33300;IGFBP3_8881;GSTM2_8759;GSTA4_8757;GSR_8755;GFPT1_8705;FABP2_32859;EPHX1_8567;EGR1_8533;CYP2C24_32875;CYP2C11_32593;CYP1A1_8415;CRYL1_8388;CCND1_8224;ASNS_8091;ALDH1L1_32662;ALDH1A1_8022;AKR7A3_8015;ACSM3_7976;AASS_7936 179.28143266666666 82.2685 3.28268 252.25367120537618 195.43236782719984 250.45573700796115 107.20544223333333 50.13005 0.808077 152.91077878028133 119.60690854252836 154.21252640483388 509.8137916666666 156.873 13.1174 877.5813556733002 494.08815237725935 702.9067541985314 25.4966;16.8949;50.527550000000005;169.209;58.7587;15.8474;42.78;6.6423;213.608;769.435;130.168;44.9033;3.28268;105.355;74.6342;981.5;146.645;24.8784;8.26335;733.935;129.934;100.909;76.0301;512.733;154.987;184.03;88.5069;19.8501;460.125;28.5735 11.3392;6.46469;20.8664;105.547;46.6655;7.7531;20.6065;3.4063;123.177;444.211;89.164;18.8755;0.808077;75.6422;57.2867;554.87;95.8536;15.4867;1.51678;463.206;45.3106;73.3629;23.2788;330.024;53.5946;111.154;65.9487;12.797;331.8;6.14642 63.97775;58.9909;154.361;459.211;78.8953;40.8362;93.6128;13.4683;668.095;2183.16;231.33;122.765;13.1174;172.041;106.529;4240.48;319.535;41.3795;45.9052;1763.75;355.143;159.385;250.463;1002.56;462.615;1150.07;133.645;32.3544;748.659;128.079 21 11 19 286954;246273;24902;305291;266730;501907;83619;24424;300850;116686;297417;25598;25315;24296;290277;25612;64392;24188;26760 UGT2B10_33303,UGT2B1_33224;TRIB3_10079;SULT2A6_32471,SULT2A6_9972;SRD5A3_9939;SLC17A3_9840;RGD1559459_9690;NFE2L2_9301;GSTM2_8759;GSTA4_8757;GSR_8755;GFPT1_8705;FABP2_32859;EPHX1_8567;CYP1A1_8415;CRYL1_8388;ASNS_8091;ALDH1L1_32662;ALDH1A1_8022;AKR7A3_8015 122.6798647368421 74.6342 215.47309699372593 71.31467721052631 46.6655 122.40806032014267 421.2700710526316 133.645 961.938558189629 25.4966;16.8949;50.527550000000005;169.209;58.7587;42.78;6.6423;3.28268;105.355;74.6342;981.5;146.645;24.8784;100.909;76.0301;154.987;184.03;88.5069;19.8501 11.3392;6.46469;20.8664;105.547;46.6655;20.6065;3.4063;0.808077;75.6422;57.2867;554.87;95.8536;15.4867;73.3629;23.2788;53.5946;111.154;65.9487;12.797 63.97775;58.9909;154.361;459.211;78.8953;93.6128;13.4683;13.1174;172.041;106.529;4240.48;319.535;41.3795;159.385;250.463;462.615;1150.07;133.645;32.3544 11 299270;307126;24539;29200;24484;24330;499353;29277;58919;24763;296925 SERPINA6_32325;MCM10_32579;LPL_32544;INHBA_33300;IGFBP3_8881;EGR1_8533;CYP2C24_32875;CYP2C11_32593;CCND1_8224;ACSM3_7976;AASS_7936 277.0477772727273 130.168 290.44756378592274 169.19858181818182 89.164 184.82771637621917 662.7529454545455 355.143 726.0994265693263 15.8474;213.608;769.435;130.168;44.9033;8.26335;733.935;129.934;512.733;460.125;28.5735 7.7531;123.177;444.211;89.164;18.8755;1.51678;463.206;45.3106;330.024;331.8;6.14642 40.8362;668.095;2183.16;231.33;122.765;45.9052;1763.75;355.143;1002.56;748.659;128.079 0 Exp 2,2(0.07);Exp 4,13(0.41);Hill,4(0.13);Linear,3(0.1);Poly 2,10(0.32) 1.9648761342280607 65.85020744800568 1.5232417583465576 5.289852619171143 0.783231785708513 1.778340995311737 89.01361572398504 269.5492496093483 52.487022788553645 161.923861678113 195.77533669515583 823.8522466381775 UP 0.6333333333333333 0.36666666666666664 0.0 GO:0097176 5 epoxide metabolic process 2 2 1 1 1 1 1 1 51 1 2494 0.99959 0.040423 0.040423 50.0 25315 ephx1 EPHX1_8567 24.8784 24.8784 24.8784 24.8784 15.4867 15.4867 15.4867 15.486700000000003 41.3795 41.3795 41.3795 41.3795 0.0 24.8784 0.0 24.8784 24.8784 15.4867 41.3795 1 0 1 25315 EPHX1_8567 24.8784 24.8784 15.4867 15.4867 41.3795 41.3795 24.8784 15.4867 41.3795 0 0 Exp 4,1(1) 2.6370131969451904 2.6370131969451904 2.6370131969451904 2.6370131969451904 0.0 2.6370131969451904 24.8784 24.8784 15.4867 15.4867 41.3795 41.3795 UP 1.0 0.0 0.0 GO:0055093 4 response to hyperoxia 24 24 2 2 2 2 2 2 50 22 2473 0.98799 0.084821 0.084821 8.33 24330;24296 egr1;cyp1a1 EGR1_8533;CYP1A1_8415 54.586175000000004 54.586175000000004 8.26335 65.51036736243547 69.70224024725275 61.924287439120725 37.43984 37.43984 1.51678 50.802878653942436 49.16225370946127 48.02189618471629 102.6451 102.6451 45.9052 80.24233610769315 121.16046538461538 75.84981867722804 0.5 54.586175000000004 8.26335;100.909 1.51678;73.3629 45.9052;159.385 1 1 1 24296 CYP1A1_8415 100.909 100.909 73.3629 73.3629 159.385 159.385 100.909 73.3629 159.385 1 24330 EGR1_8533 8.26335 8.26335 1.51678 1.51678 45.9052 45.9052 8.26335 1.51678 45.9052 0 Hill,1(0.5);Poly 2,1(0.5) 3.1754513820072274 7.196047782897949 1.9061951637268066 5.289852619171143 2.3926071319571083 3.5980238914489746 -36.206562 145.378912 -32.9693576 107.8490376 -8.565103999999991 213.85530399999996 CONFLICT 0.5 0.5 0.0 GO:0006629 4 lipid metabolic process 289 320 34 32 15 29 14 14 38 306 2189 0.99876 0.003665 0.004526 4.38 24902;305291;299270;501907;24539;24424;25598;25315;499353;29277;24296;290277;24188;24763 sult2a6;srd5a3;serpina6;rgd1559459;lpl;gstm2;fabp2;ephx1;cyp2c24;cyp2c11;cyp1a1;cryl1;aldh1a1;acsm3 SULT2A6_32471,SULT2A6_9972;SRD5A3_9939;SERPINA6_32325;RGD1559459_9690;LPL_32544;GSTM2_8759;FABP2_32859;EPHX1_8567;CYP2C24_32875;CYP2C11_32593;CYP1A1_8415;CRYL1_8388;ALDH1A1_8022;ACSM3_7976 200.86035928571428 94.70795000000001 3.28268 259.2381465858576 273.14857999389193 298.96598591256503 122.43138407142858 55.62965 0.808077 163.12742885099388 168.9093464834388 183.05717222792205 479.7327071428572 204.92399999999998 13.1174 667.7589471241555 663.5521471014491 799.7931327089791 50.527550000000005;169.209;15.8474;42.78;769.435;3.28268;146.645;24.8784;733.935;129.934;100.909;76.0301;88.5069;460.125 20.8664;105.547;7.7531;20.6065;444.211;0.808077;95.8536;15.4867;463.206;45.3106;73.3629;23.2788;65.9487;331.8 154.361;459.211;40.8362;93.6128;2183.16;13.1174;319.535;41.3795;1763.75;355.143;159.385;250.463;133.645;748.659 10 5 9 24902;305291;501907;24424;25598;25315;24296;290277;24188 SULT2A6_32471,SULT2A6_9972;SRD5A3_9939;RGD1559459_9690;GSTM2_8759;FABP2_32859;EPHX1_8567;CYP1A1_8415;CRYL1_8388;ALDH1A1_8022 78.08540333333333 76.0301 54.85209203006846 46.862075222222224 23.2788 38.62863091160331 180.52329999999998 154.361 141.48793439143495 50.527550000000005;169.209;42.78;3.28268;146.645;24.8784;100.909;76.0301;88.5069 20.8664;105.547;20.6065;0.808077;95.8536;15.4867;73.3629;23.2788;65.9487 154.361;459.211;93.6128;13.1174;319.535;41.3795;159.385;250.463;133.645 5 299270;24539;499353;29277;24763 SERPINA6_32325;LPL_32544;CYP2C24_32875;CYP2C11_32593;ACSM3_7976 421.85527999999994 460.125 342.6844091866334 258.45614 331.8 217.9964050566385 1018.3096399999998 748.659 919.3086366226242 15.8474;769.435;733.935;129.934;460.125 7.7531;444.211;463.206;45.3106;331.8 40.8362;2183.16;1763.75;355.143;748.659 0 Exp 2,1(0.07);Exp 4,6(0.4);Hill,2(0.14);Linear,2(0.14);Poly 2,4(0.27) 1.8980771069719138 28.912619829177856 1.5321133136749268 2.79919695854187 0.3702298653969713 1.8130581378936768 65.06311363079584 336.65760494063267 36.98001119102196 207.88275695183523 129.93917955004912 829.5262347356652 UP 0.6428571428571429 0.35714285714285715 0.0 GO:1901566 5 organonitrogen compound biosynthetic process 169 188 15 13 8 9 4 4 48 184 2311 0.66223 0.54251 0.79121 2.13 29200;25612;64392;296925 inhba;asns;aldh1l1;aass INHBA_33300;ASNS_8091;ALDH1L1_32662;AASS_7936 124.439625 142.5775 28.5735 67.59507653344654 97.01326894206711 75.4401692153362 65.01475500000001 71.3793 6.14642 45.85454092067035 48.241412533521526 49.183305463884466 493.0235 346.9725 128.079 459.8198038569022 382.7436528517355 426.1643272906748 130.168;154.987;184.03;28.5735 89.164;53.5946;111.154;6.14642 231.33;462.615;1150.07;128.079 2 2 2 25612;64392 ASNS_8091;ALDH1L1_32662 169.5085 169.5085 20.536502246000886 82.3743 82.3743 40.70064206102896 806.3425 806.3425 486.1040922605982 154.987;184.03 53.5946;111.154 462.615;1150.07 2 29200;296925 INHBA_33300;AASS_7936 79.37075 79.37075 71.83815988125671 47.655210000000004 47.655210000000004 58.702293775696695 179.7045 179.7045 73.0094822642923 130.168;28.5735 89.164;6.14642 231.33;128.079 0 Exp 4,1(0.25);Hill,1(0.25);Poly 2,2(0.5) 1.8718130953418712 7.64876115322113 1.6175053119659424 2.634152889251709 0.485538035399534 1.6985514760017395 58.196449997222345 190.6828000027776 20.077304897743048 109.95220510225697 42.40009222023588 943.646907779764 CONFLICT 0.5 0.5 0.0 GO:0071774 4 response to fibroblast growth factor 28 30 3 3 2 1 1 1 51 29 2466 0.87613 0.46335 0.46335 3.33 494344 ier2 IER2_32643 543.54 543.54 543.54 543.54 375.947 375.947 375.947 375.947 978.946 978.946 978.946 978.946 543.54 375.947 978.946 0 1 0 1 494344 IER2_32643 543.54 543.54 375.947 375.947 978.946 978.946 543.54 375.947 978.946 0 Linear,1(1) 1.5710276365280151 1.5710276365280151 1.5710276365280151 1.5710276365280151 0.0 1.5710276365280151 543.54 543.54 375.947 375.947 978.946 978.946 DOWN 0.0 1.0 0.0 GO:0071260 5 cellular response to mechanical stimulus 54 54 2 2 2 2 2 2 50 52 2443 0.90379 0.30257 0.30257 3.7 59107;24330 ltbp1;egr1 LTBP1_33264;EGR1_8533 503.520175 503.520175 8.26335 700.3989187728386 594.6776558553806 688.432475110205 254.33139 254.33139 1.51678 357.53385022806475 300.8647072764161 351.42531898741873 2555.9126 2555.9126 45.9052 3549.6865067368303 3017.9071449764647 3489.0394633671744 998.777;8.26335 507.146;1.51678 5065.92;45.9052 0 2 0 2 59107;24330 LTBP1_33264;EGR1_8533 503.520175 503.520175 700.3989187728386 254.33139 254.33139 357.53385022806475 2555.9126 2555.9126 3549.6865067368303 998.777;8.26335 507.146;1.51678 5065.92;45.9052 0 Exp 2,1(0.5);Hill,1(0.5) 2.9478591148034714 6.932596564292908 1.6427439451217651 5.289852619171143 2.5788952751445926 3.466298282146454 -467.18320199999994 1474.223552 -241.18524559999992 749.8480255999999 -2363.701904 7475.527104000001 DOWN 0.0 1.0 0.0 GO:0071280 7 cellular response to copper ion 11 12 4 4 2 4 2 2 50 10 2485 0.99845 0.023677 0.023677 16.67 83619;24296 nfe2l2;cyp1a1 NFE2L2_9301;CYP1A1_8415 53.775650000000006 53.775650000000006 6.6423 66.65662281007792 76.3909191611842 58.48251504492078 38.3846 38.3846 3.4063 49.46678624875483 55.16769878887559 43.40066971678761 86.42665 86.42665 13.4683 103.17868805836311 121.43313103319377 90.52587608408047 0.0 6.6423 0.5 53.775650000000006 6.6423;100.909 3.4063;73.3629 13.4683;159.385 2 0 2 83619;24296 NFE2L2_9301;CYP1A1_8415 53.775650000000006 53.775650000000006 66.65662281007792 38.3846 38.3846 49.46678624875483 86.42665 86.42665 103.17868805836311 6.6423;100.909 3.4063;73.3629 13.4683;159.385 0 0 Exp 4,1(0.5);Poly 2,1(0.5) 1.7146591838082728 3.448564052581787 1.5423688888549805 1.9061951637268066 0.2572640261357091 1.7242820262908936 -38.605716 146.157016 -30.172867999999987 106.94206799999998 -56.57171599999998 229.42501599999997 UP 1.0 0.0 0.0 GO:1905952 5 regulation of lipid localization 57 62 7 6 3 6 3 3 49 59 2436 0.96394 0.13123 0.13123 4.84 24539;24484;114628 lpl;igfbp3;abcg5 LPL_32544;IGFBP3_8881;ABCG5_7947 391.76876666666664 360.968 44.9033 363.2465574464035 388.78873994484024 372.00026813821614 245.57783333333336 273.647 18.8755 214.05251803724084 241.47367520876426 219.5067212008367 944.8376666666667 528.588 122.765 1091.4461634713518 953.1323029954798 1109.3197896718696 769.435;44.9033;360.968 444.211;18.8755;273.647 2183.16;122.765;528.588 0 3 0 3 24539;24484;114628 LPL_32544;IGFBP3_8881;ABCG5_7947 391.76876666666664 360.968 363.2465574464035 245.57783333333336 273.647 214.05251803724084 944.8376666666667 528.588 1091.4461634713518 769.435;44.9033;360.968 444.211;18.8755;273.647 2183.16;122.765;528.588 0 Exp 2,1(0.34);Exp 4,1(0.34);Linear,1(0.34) 1.8190192936035643 5.496917366981506 1.6548216342926025 2.1518702507019043 0.2773165014887644 1.6902254819869995 -19.28340887214972 802.820942205483 3.3546066706775264 487.80105999598914 -290.24993645422546 2179.9252697875586 DOWN 0.0 1.0 0.0 GO:0002244 5 hematopoietic progenitor cell differentiation 30 31 2 2 2 2 2 2 50 29 2466 0.97588 0.13074 0.13074 6.45 29200;25695 inhba;cebpd INHBA_33300;CEBPD_8283 67.914175 67.914175 5.66035 88.04020362460125 48.11703727972927 83.46989954726503 45.660975 45.660975 2.15795 61.52256795925582 31.826718596102232 58.32883564587654 123.84 123.84 16.35 152.013815819484 89.65745244485937 144.1225419054254 0.5 67.914175 130.168;5.66035 89.164;2.15795 231.33;16.35 0 2 0 2 29200;25695 INHBA_33300;CEBPD_8283 67.914175 67.914175 88.04020362460125 45.660975 45.660975 61.52256795925582 123.84 123.84 152.013815819484 130.168;5.66035 89.164;2.15795 231.33;16.35 0 Exp 4,1(0.5);Poly 2,1(0.5) 1.606407889838051 3.2133419513702393 1.577596664428711 1.6357452869415283 0.041117285295469916 1.6066709756851196 -54.103322000000006 189.931672 -39.604954 130.926904 -86.84039999999999 334.5204 DOWN 0.0 1.0 0.0 GO:0070848 5 response to growth factor 153 159 6 6 4 4 3 3 49 156 2339 0.59011 0.64047 1.0 1.89 59107;494344;24330 ltbp1;ier2;egr1 LTBP1_33264;IER2_32643;EGR1_8533 516.8601166666666 543.54 8.26335 495.79550707937136 583.0731071867747 524.862031551884 294.8699266666667 375.947 1.51678 262.3839665350689 317.90295640002506 270.35002587999213 2030.2570666666668 978.946 45.9052 2670.0334018934323 2555.21046002886 2855.2032347832783 998.777;543.54;8.26335 507.146;375.947;1.51678 5065.92;978.946;45.9052 0 3 0 3 59107;494344;24330 LTBP1_33264;IER2_32643;EGR1_8533 516.8601166666666 543.54 495.79550707937136 294.8699266666667 375.947 262.3839665350689 2030.2570666666668 978.946 2670.0334018934323 998.777;543.54;8.26335 507.146;375.947;1.51678 5065.92;978.946;45.9052 0 Exp 2,1(0.34);Hill,1(0.34);Linear,1(0.34) 2.390006547932042 8.503624200820923 1.5710276365280151 5.289852619171143 2.1266642173748376 1.6427439451217651 -44.18531550488615 1077.9055488382194 -2.045482605058396 591.7853359383918 -991.1701598571253 5051.684293190458 DOWN 0.0 1.0 0.0 GO:0046395 6 carboxylic acid catabolic process 80 87 8 8 3 5 2 2 50 85 2410 0.7388 0.53645 0.69752 2.3 64392;296925 aldh1l1;aass ALDH1L1_32662;AASS_7936 106.30175 106.30175 28.5735 109.92434532952652 70.6782732805843 97.70003842868996 58.65021 58.65021 6.14642 74.25157189398888 34.5873044187462 65.99431095710847 639.0745 639.0745 128.079 722.6567664116208 404.8811880706026 642.29260258513 184.03;28.5735 111.154;6.14642 1150.07;128.079 1 1 1 64392 ALDH1L1_32662 184.03 184.03 111.154 111.154 1150.07 1150.07 184.03 111.154 1150.07 1 296925 AASS_7936 28.5735 28.5735 6.14642 6.14642 128.079 128.079 28.5735 6.14642 128.079 0 Hill,1(0.5);Poly 2,1(0.5) 1.6878996947418512 3.378862977027893 1.6175053119659424 1.7613576650619507 0.10171897436382911 1.6894314885139465 -46.045619999999985 258.64912 -44.257218399999985 161.55763839999997 -362.47668 1640.6256799999999 CONFLICT 0.5 0.5 0.0 GO:0001819 6 positive regulation of cytokine production 132 142 5 4 4 4 4 4 48 138 2357 0.83911 0.32907 0.53212 2.82 360918;24614;24539;24330 pf4;orm1;lpl;egr1 PF4_32963;ORM1_9400;LPL_32544;EGR1_8533 253.57791249999997 118.30665 8.26335 351.3809661042564 315.84013068566014 403.4638835712747 143.150995 63.4381 1.51678 206.47116076508792 175.56013856930818 239.06532786295998 729.6818 344.831 45.9052 981.455913177982 935.9150036035294 1109.645617582897 179.631;56.9823;769.435;8.26335 110.795;16.0812;444.211;1.51678 426.677;262.985;2183.16;45.9052 2 2 2 360918;24614 PF4_32963;ORM1_9400 118.30665 118.30665 86.72572747371449 63.4381 63.4381 66.97277025194643 344.831 344.831 115.74772322598835 179.631;56.9823 110.795;16.0812 426.677;262.985 2 24539;24330 LPL_32544;EGR1_8533 388.84917499999995 388.84917499999995 538.2296353619533 222.86389 222.86389 313.0320849540894 1114.5326 1114.5326 1511.2673622034981 769.435;8.26335 444.211;1.51678 2183.16;45.9052 0 Exp 2,1(0.25);Exp 4,1(0.25);Hill,1(0.25);Poly 2,1(0.25) 2.2656829703581476 10.424558758735657 1.5846891403198242 5.289852619171143 1.7927270421565533 1.775008499622345 -90.77543428217137 597.9312592821714 -59.19074254978611 345.4927325497862 -232.14499491442234 1691.5085949144222 CONFLICT 0.5 0.5 0.0 GO:0042127 5 regulation of cell population proliferation 436 466 19 17 9 11 6 6 46 460 2035 0.1351 0.93441 0.27546 1.29 360918;29200;24484;25587;24330;58919 pf4;inhba;igfbp3;id2;egr1;ccnd1 PF4_32963;INHBA_33300;IGFBP3_8881;ID2_8861;EGR1_8533;CCND1_8224 146.44923166666666 87.53565 2.99674 192.6216180464685 163.74465424540608 222.5728459668546 91.89563733333334 54.01975 0.998544 125.56458477097846 101.5384972358269 146.10932770764504 306.69186666666667 177.0475 10.914 372.4598304140014 338.5739896157143 423.7047529874709 179.631;130.168;44.9033;2.99674;8.26335;512.733 110.795;89.164;18.8755;0.998544;1.51678;330.024 426.677;231.33;122.765;10.914;45.9052;1002.56 2 4 2 360918;25587 PF4_32963;ID2_8861 91.31387 91.31387 124.89928303586774 55.896772 55.896772 77.6378185878504 218.7955 218.7955 293.9888366664626 179.631;2.99674 110.795;0.998544 426.677;10.914 4 29200;24484;24330;58919 INHBA_33300;IGFBP3_8881;EGR1_8533;CCND1_8224 174.0169125 87.53565 231.51377458874293 109.89507 54.01975 151.56620000580472 350.64005 177.0475 441.21985315563103 130.168;44.9033;8.26335;512.733 89.164;18.8755;1.51678;330.024 231.33;122.765;45.9052;1002.56 0 Exp 2,1(0.17);Exp 4,1(0.17);Hill,2(0.34);Poly 2,2(0.34) 2.0840142174244605 13.973414540290833 1.555469274520874 5.289852619171143 1.4590175311752043 1.7573065757751465 -7.680163030087101 300.5786263634204 -8.57695573475793 192.36823040142457 8.66193216203294 604.7218011713004 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0018130 5 heterocycle biosynthetic process 162 180 14 12 7 8 3 3 49 177 2318 0.49285 0.72368 1.0 1.67 297417;24330;64392 gfpt1;egr1;aldh1l1 GFPT1_8705;EGR1_8533;ALDH1L1_32662 391.26444999999995 184.03 8.26335 518.6588302303428 175.24146979561374 370.7857577290077 222.51359333333335 111.154 1.51678 293.0028426340197 99.42983959811689 210.99453665231513 1812.1517333333331 1150.07 45.9052 2174.2535740821518 871.8358135721667 1613.7466087558112 981.5;8.26335;184.03 554.87;1.51678;111.154 4240.48;45.9052;1150.07 2 1 2 297417;64392 GFPT1_8705;ALDH1L1_32662 582.765 582.765 563.8964447928361 333.012 333.012 313.7545925209701 2695.2749999999996 2695.2749999999996 2185.2498676467185 981.5;184.03 554.87;111.154 4240.48;1150.07 1 24330 EGR1_8533 8.26335 8.26335 1.51678 1.51678 45.9052 45.9052 8.26335 1.51678 45.9052 0 Hill,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 2.421140473062399 8.57445204257965 1.5232417583465576 5.289852619171143 2.1092784391463764 1.7613576650619507 -195.65326789208717 978.1821678920871 -109.05033600009727 554.077522666764 -648.2478037810265 4272.551270447693 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0040011 2 locomotion 209 224 6 6 3 5 3 3 49 221 2274 0.31554 0.84982 0.62062 1.34 360918;494344;25587 pf4;ier2;id2 PF4_32963;IER2_32643;ID2_8861 242.05591333333334 179.631 2.99674 275.6254820156556 325.1652751472143 301.3502515900469 162.58018133333334 110.795 0.998544 192.7637541616438 222.528482452061 210.50916008555976 472.17900000000003 426.677 10.914 485.6174546482035 603.0487028536918 530.3745474021827 179.631;543.54;2.99674 110.795;375.947;0.998544 426.677;978.946;10.914 2 1 2 360918;25587 PF4_32963;ID2_8861 91.31387 91.31387 124.89928303586774 55.896772 55.896772 77.6378185878504 218.7955 218.7955 293.9888366664626 179.631;2.99674 110.795;0.998544 426.677;10.914 1 494344 IER2_32643 543.54 543.54 375.947 375.947 978.946 978.946 543.54 375.947 978.946 0 Hill,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 1.7944802008156995 5.4085533618927 1.5710276365280151 1.9777342081069946 0.20924678113986375 1.8597915172576904 -69.84368129169462 553.9555079583613 -55.55254116291337 380.71290382958 -77.34888160206958 1021.7068816020695 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0048519 4 negative regulation of biological process 1024 1094 52 50 29 37 23 23 29 1071 1424 0.63116 0.47888 0.88793 2.1 24522;308843;246273;299270;363140;360918;24614;24314;316351;83619;59107;24539;29200;24484;25587;24424;297417;24330;25695;58919;25612;24188;114628 zfp354a;tsku;trib3;serpina6;rassf1;pf4;orm1;nqo1;npas2;nfe2l2;ltbp1;lpl;inhba;igfbp3;id2;gstm2;gfpt1;egr1;cebpd;ccnd1;asns;aldh1a1;abcg5 ZFP354A_10203;TSKU_10094;TRIB3_10079;SERPINA6_32325;RASSF1_32475;PF4_32963;ORM1_9400;NQO1_33055;NPAS2_9350;NFE2L2_9301;LTBP1_33264;LPL_32544;INHBA_33300;IGFBP3_8881;ID2_8861;GSTM2_8759;GFPT1_8705;EGR1_8533;CEBPD_8283;CCND1_8224;ASNS_8091;ALDH1A1_8022;ABCG5_7947 228.8140569565217 56.9823 2.99674 331.6685622637294 277.62406297530794 342.85234780080344 130.490807 18.8755 0.808077 188.0089508129268 158.8478566653417 194.62231834381214 704.608152173913 133.645 6.6682 1345.4721338887532 775.4136984534462 1326.1813132476202 3.26713;6.12626;16.8949;15.8474;756.581;179.631;56.9823;24.1117;134.458;6.6423;998.777;769.435;130.168;44.9033;2.99674;3.28268;981.5;8.26335;5.66035;512.733;154.987;88.5069;360.968 1.71987;1.46625;6.46469;7.7531;437.5;110.795;16.0812;16.4151;56.7249;3.4063;507.146;444.211;89.164;18.8755;0.998544;0.808077;554.87;1.51678;2.15795;330.024;53.5946;65.9487;273.647 6.6682;41.3339;58.9909;40.8362;940.187;426.677;262.985;37.0434;320.448;13.4683;5065.92;2183.16;231.33;122.765;10.914;13.1174;4240.48;45.9052;16.35;1002.56;462.615;133.645;528.588 11 12 11 246273;363140;360918;24614;24314;83619;25587;24424;297417;25612;24188 TRIB3_10079;RASSF1_32475;PF4_32963;ORM1_9400;NQO1_33055;NFE2L2_9301;ID2_8861;GSTM2_8759;GFPT1_8705;ASNS_8091;ALDH1A1_8022 206.55604727272728 56.9823 336.85858468331116 115.1711100909091 16.4151 193.2508696454038 600.0111818181817 133.645 1240.7210539540163 16.8949;756.581;179.631;56.9823;24.1117;6.6423;2.99674;3.28268;981.5;154.987;88.5069 6.46469;437.5;110.795;16.0812;16.4151;3.4063;0.998544;0.808077;554.87;53.5946;65.9487 58.9909;940.187;426.677;262.985;37.0434;13.4683;10.914;13.1174;4240.48;462.615;133.645 12 24522;308843;299270;316351;59107;24539;29200;24484;24330;25695;58919;114628 ZFP354A_10203;TSKU_10094;SERPINA6_32325;NPAS2_9350;LTBP1_33264;LPL_32544;INHBA_33300;IGFBP3_8881;EGR1_8533;CEBPD_8283;CCND1_8224;ABCG5_7947 249.2172325 87.53565 340.44177578665887 144.5338625 37.8002 190.5100673931322 800.4887083333333 177.0475 1483.299322745839 3.26713;6.12626;15.8474;134.458;998.777;769.435;130.168;44.9033;8.26335;5.66035;512.733;360.968 1.71987;1.46625;7.7531;56.7249;507.146;444.211;89.164;18.8755;1.51678;2.15795;330.024;273.647 6.6682;41.3339;40.8362;320.448;5065.92;2183.16;231.33;122.765;45.9052;16.35;1002.56;528.588 0 Exp 2,3(0.14);Exp 4,9(0.4);Hill,5(0.22);Linear,2(0.09);Poly 2,4(0.18) 2.1520087650111313 54.625452637672424 1.5232417583465576 6.495501518249512 1.3213997220487552 1.8597915172576904 93.2650121502368 364.36310176280665 53.653757616164086 207.32785638383595 154.7294982631596 1254.4868060846666 CONFLICT 0.4782608695652174 0.5217391304347826 0.0 GO:0070887 4 cellular response to chemical stimulus 594 635 46 41 27 30 21 21 31 614 1881 0.99585 0.009529 0.014136 3.31 286954;246273;170698;360918;24614;24314;83619;59107;24539;29200;24484;25587;24424;300850;116686;297417;25315;24330;24296;58919;25612 ugt2b1;trib3;slco1a2;pf4;orm1;nqo1;nfe2l2;ltbp1;lpl;inhba;igfbp3;id2;gstm2;gsta4;gsr;gfpt1;ephx1;egr1;cyp1a1;ccnd1;asns UGT2B10_33303,UGT2B1_33224;TRIB3_10079;SLCO1A2_9886;PF4_32963;ORM1_9400;NQO1_33055;NFE2L2_9301;LTBP1_33264;LPL_32544;INHBA_33300;IGFBP3_8881;ID2_8861;GSTM2_8759;GSTA4_8757;GSR_8755;GFPT1_8705;EPHX1_8567;EGR1_8533;CYP1A1_8415;CCND1_8224;ASNS_8091 222.07502238095236 74.6342 2.99674 322.6647631520563 256.33252977915544 335.1464727678555 127.94473766666665 53.5946 0.808077 181.10148320785603 146.65972248664218 185.97174307054962 737.7983071428571 159.385 10.914 1399.9186598685687 840.6671457869649 1451.7422959272137 25.4966;16.8949;440.994;179.631;56.9823;24.1117;6.6423;998.777;769.435;130.168;44.9033;2.99674;3.28268;105.355;74.6342;981.5;24.8784;8.26335;100.909;512.733;154.987 11.3392;6.46469;299.351;110.795;16.0812;16.4151;3.4063;507.146;444.211;89.164;18.8755;0.998544;0.808077;75.6422;57.2867;554.87;15.4867;1.51678;73.3629;330.024;53.5946 63.97775;58.9909;772.521;426.677;262.985;37.0434;13.4683;5065.92;2183.16;231.33;122.765;10.914;13.1174;172.041;106.529;4240.48;41.3795;45.9052;159.385;1002.56;462.615 15 7 14 286954;246273;360918;24614;24314;83619;25587;24424;300850;116686;297417;25315;24296;25612 UGT2B10_33303,UGT2B1_33224;TRIB3_10079;PF4_32963;ORM1_9400;NQO1_33055;NFE2L2_9301;ID2_8861;GSTM2_8759;GSTA4_8757;GSR_8755;GFPT1_8705;EPHX1_8567;CYP1A1_8415;ASNS_8091 125.59298714285715 41.239450000000005 252.84525319091725 71.18222935714286 16.24815 143.42755816379747 433.5430892857143 85.253375 1105.6826412516427 25.4966;16.8949;179.631;56.9823;24.1117;6.6423;2.99674;3.28268;105.355;74.6342;981.5;24.8784;100.909;154.987 11.3392;6.46469;110.795;16.0812;16.4151;3.4063;0.998544;0.808077;75.6422;57.2867;554.87;15.4867;73.3629;53.5946 63.97775;58.9909;426.677;262.985;37.0434;13.4683;10.914;13.1174;172.041;106.529;4240.48;41.3795;159.385;462.615 7 170698;59107;24539;29200;24484;24330;58919 SLCO1A2_9886;LTBP1_33264;LPL_32544;INHBA_33300;IGFBP3_8881;EGR1_8533;CCND1_8224 415.03909285714286 440.994 378.63410429449164 241.4697542857143 299.351 205.4274600226707 1346.3087428571428 772.521 1798.81950942361 440.994;998.777;769.435;130.168;44.9033;8.26335;512.733 299.351;507.146;444.211;89.164;18.8755;1.51678;330.024 772.521;5065.92;2183.16;231.33;122.765;45.9052;1002.56 0 Exp 2,4(0.19);Exp 4,9(0.41);Hill,3(0.14);Linear,1(0.05);Poly 2,5(0.23) 1.997290697918134 46.98883140087128 1.5232417583465576 5.289852619171143 0.992404733004698 1.7042611241340637 84.06902359861806 360.08102116328666 50.48635384158109 205.4031214917523 139.04320608416413 1336.5534082015502 UP 0.6666666666666666 0.3333333333333333 0.0 GO:1904880 5 response to hydrogen sulfide 3 3 1 1 1 1 1 1 51 2 2493 0.99879 0.06003 0.06003 33.33 24314 nqo1 NQO1_33055 24.1117 24.1117 24.1117 24.111700000000003 16.4151 16.4151 16.4151 16.4151 37.0434 37.0434 37.0434 37.0434 0.0 24.1117 0.0 24.1117 24.1117 16.4151 37.0434 1 0 1 24314 NQO1_33055 24.1117 24.1117 16.4151 16.4151 37.0434 37.0434 24.1117 16.4151 37.0434 0 0 Exp 4,1(1) 4.773829460144043 4.773829460144043 4.773829460144043 4.773829460144043 0.0 4.773829460144043 24.1117 24.1117 16.4151 16.4151 37.0434 37.0434 UP 1.0 0.0 0.0 GO:0072330 7 monocarboxylic acid biosynthetic process 51 55 12 9 6 9 6 6 46 49 2446 0.99991 7.2772E-4 7.2772E-4 10.91 24539;24424;24296;25612;24188;24763 lpl;gstm2;cyp1a1;asns;aldh1a1;acsm3 LPL_32544;GSTM2_8759;CYP1A1_8415;ASNS_8091;ALDH1A1_8022;ACSM3_7976 262.8742633333333 127.94800000000001 3.28268 293.6582396927886 326.9638056144118 321.9680221160058 161.6208795 69.6558 0.808077 180.71589893785043 201.7959123532868 187.99297796871332 616.7635666666666 311.0 13.1174 812.6184060842373 795.9580889763779 946.6085450265211 1.5 94.70795000000001 4.5 614.78 769.435;3.28268;100.909;154.987;88.5069;460.125 444.211;0.808077;73.3629;53.5946;65.9487;331.8 2183.16;13.1174;159.385;462.615;133.645;748.659 4 2 4 24424;24296;25612;24188 GSTM2_8759;CYP1A1_8415;ASNS_8091;ALDH1A1_8022 86.92139499999999 94.70795000000001 62.78675059439506 48.428569249999995 59.77165 32.77740577130201 192.19060000000002 146.515 191.22444207816807 3.28268;100.909;154.987;88.5069 0.808077;73.3629;53.5946;65.9487 13.1174;159.385;462.615;133.645 2 24539;24763 LPL_32544;ACSM3_7976 614.78 614.78 218.71519848881078 388.0055 388.0055 79.48658037996132 1465.9095 1465.9095 1014.345384718883 769.435;460.125 444.211;331.8 2183.16;748.659 0 Exp 2,1(0.17);Exp 4,1(0.17);Hill,1(0.17);Linear,1(0.17);Poly 2,2(0.34) 2.008648208059686 12.356298685073853 1.620619773864746 2.79919695854187 0.5205547721557984 1.806051790714264 27.898733636325147 497.8497930303415 17.018044170005368 306.2237148299946 -33.46658049671737 1266.9937138300506 UP 0.6666666666666666 0.3333333333333333 0.0 GO:2001236 7 regulation of extrinsic apoptotic signaling pathway 62 65 4 4 3 3 3 3 49 62 2433 0.95815 0.1454 0.1454 4.62 360918;29200;289388 pf4;inhba;g0s2 PF4_32963;INHBA_33300;G0S2_32729 104.41661333333333 130.168 3.45084 90.86920617485625 113.36979836440169 73.61091035830634 67.01091333333333 89.164 1.07374 58.11848381231684 74.90174833433554 47.96732152554349 224.10973333333334 231.33 14.3222 206.27219749353847 224.9831529765484 162.7603192380051 179.631;130.168;3.45084 110.795;89.164;1.07374 426.677;231.33;14.3222 2 1 2 360918;289388 PF4_32963;G0S2_32729 91.54092 91.54092 124.57818584653091 55.93437 55.93437 77.58464698633229 220.49960000000002 220.49960000000002 291.57887533482256 179.631;3.45084 110.795;1.07374 426.677;14.3222 1 29200 INHBA_33300 130.168 130.168 89.164 89.164 231.33 231.33 130.168 89.164 231.33 0 Exp 4,1(0.34);Poly 2,2(0.67) 1.849782811526381 5.576106548309326 1.6357452869415283 2.0805697441101074 0.22241422933582777 1.8597915172576904 1.5884264669756192 207.244800199691 1.2436576764226288 132.77816899024404 -9.30923181515763 457.52869848182434 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0045944 9 positive regulation of transcription by RNA polymerase II 241 260 16 15 8 11 7 7 45 253 2242 0.84563 0.27676 0.48309 2.69 360918;316351;83619;29200;494344;24330;25695 pf4;npas2;nfe2l2;inhba;ier2;egr1;cebpd PF4_32963;NPAS2_9350;NFE2L2_9301;INHBA_33300;IER2_32643;EGR1_8533;CEBPD_8283 144.05185714285713 130.168 5.66035 190.44402921833844 124.63737653788259 180.52750799953031 91.38741857142857 56.7249 1.51678 133.12685075234606 74.55102683425322 126.05085231879174 290.44635714285715 231.33 13.4683 343.66442527511174 255.66899184144503 324.9979418216288 179.631;134.458;6.6423;130.168;543.54;8.26335;5.66035 110.795;56.7249;3.4063;89.164;375.947;1.51678;2.15795 426.677;320.448;13.4683;231.33;978.946;45.9052;16.35 2 5 2 360918;83619 PF4_32963;NFE2L2_9301 93.13665 93.13665 122.3214828386453 57.10065 57.10065 75.93527799280778 220.07265 220.07265 292.1826738152778 179.631;6.6423 110.795;3.4063 426.677;13.4683 5 316351;29200;494344;24330;25695 NPAS2_9350;INHBA_33300;IER2_32643;EGR1_8533;CEBPD_8283 164.41794 130.168 221.01607471750043 105.102126 56.7249 155.94770991119228 318.59584 231.33 390.318403383863 134.458;130.168;543.54;8.26335;5.66035 56.7249;89.164;375.947;1.51678;2.15795 320.448;231.33;978.946;45.9052;16.35 0 Exp 4,2(0.29);Hill,2(0.29);Linear,1(0.15);Poly 2,2(0.29) 1.972547256862493 15.36524510383606 1.5423688888549805 5.289852619171143 1.3719462585322024 1.6357452869415283 2.968945945981318 285.13476833973294 -7.2343326050288965 190.00916974788606 35.8561880962491 545.0365261894652 DOWN 0.2857142857142857 0.7142857142857143 0.0 GO:0008202 5 steroid metabolic process 95 104 13 13 4 13 4 4 48 100 2395 0.94145 0.16039 0.16039 3.85 24902;299270;501907;24296 sult2a6;serpina6;rgd1559459;cyp1a1 SULT2A6_32471,SULT2A6_9972;SERPINA6_32325;RGD1559459_9690;CYP1A1_8415 52.51598750000001 46.653775 15.8474 35.520943607782876 65.22208869646883 32.55580979016355 30.647225 20.736449999999998 7.7531 29.12759600120076 39.78977706235913 29.958541534567736 112.04874999999998 123.98689999999999 40.8362 56.10157037026684 130.6587334109692 40.51256700268478 50.527550000000005;15.8474;42.78;100.909 20.8664;7.7531;20.6065;73.3629 154.361;40.8362;93.6128;159.385 4 1 3 24902;501907;24296 SULT2A6_32471,SULT2A6_9972;RGD1559459_9690;CYP1A1_8415 64.73885 50.527550000000005 31.562888746398038 38.2786 20.8664 30.384172966694354 135.78626666666665 154.361 36.60957678003571 50.527550000000005;42.78;100.909 20.8664;20.6065;73.3629 154.361;93.6128;159.385 1 299270 SERPINA6_32325 15.8474 15.8474 7.7531 7.7531 40.8362 40.8362 15.8474 7.7531 40.8362 0 Exp 4,4(0.8);Poly 2,1(0.2) 1.9003833046053795 9.536997556686401 1.657426357269287 2.0820155143737793 0.18102959920592593 1.9061951637268066 17.705462764372783 87.32651223562723 2.102180918823251 59.19226908117675 57.06921103713852 167.02828896286147 UP 0.75 0.25 0.0 GO:0051046 6 regulation of secretion 220 238 11 10 6 9 5 5 47 233 2262 0.64251 0.54356 0.81264 2.1 170698;24614;24539;29200;24484 slco1a2;orm1;lpl;inhba;igfbp3 SLCO1A2_9886;ORM1_9400;LPL_32544;INHBA_33300;IGFBP3_8881 288.49652000000003 130.168 44.9033 313.27372778794745 291.95582101908997 344.1034586284889 173.53654 89.164 16.0812 190.34500816663933 169.02305017367587 207.4422776813782 714.5522 262.985 122.765 858.4576245754357 782.1296008899095 948.1653868740996 440.994;56.9823;769.435;130.168;44.9033 299.351;16.0812;444.211;89.164;18.8755 772.521;262.985;2183.16;231.33;122.765 1 4 1 24614 ORM1_9400 56.9823 56.9823 16.0812 16.0812 262.985 262.985 56.9823 16.0812 262.985 4 170698;24539;29200;24484 SLCO1A2_9886;LPL_32544;INHBA_33300;IGFBP3_8881 346.375075 285.581 329.4253438493905 212.900375 194.2575 194.88001301457908 827.444 501.9255 947.4363307758467 440.994;769.435;130.168;44.9033 299.351;444.211;89.164;18.8755 772.521;2183.16;231.33;122.765 0 Exp 2,2(0.4);Exp 4,2(0.4);Poly 2,1(0.2) 1.6472388062344683 8.238216876983643 1.5846891403198242 1.6902254819869995 0.04061763712978477 1.6548216342926025 13.899990447742823 563.0930495522571 6.691784044163597 340.38129595583644 -37.91908490663798 1467.0234849066383 DOWN 0.2 0.8 0.0 GO:0009612 4 response to mechanical stimulus 121 126 6 6 6 5 5 5 47 121 2374 0.95907 0.11148 0.18103 3.97 25333;59107;116686;24330;25612 mgp;ltbp1;gsr;egr1;asns MGP_33209;LTBP1_33264;GSR_8755;EGR1_8533;ASNS_8091 262.35241 75.1005 8.26335 414.94311736582404 290.10579852463803 443.1699921570742 126.695056 53.5946 1.51678 214.061559687186 141.42346243134457 228.8951417431954 1205.44004 346.231 45.9052 2164.8014490385735 1375.1127763552554 2303.355306643866 75.1005;998.777;74.6342;8.26335;154.987 13.9312;507.146;57.2867;1.51678;53.5946 346.231;5065.92;106.529;45.9052;462.615 2 3 2 116686;25612 GSR_8755;ASNS_8091 114.8106 114.8106 56.81800976732645 55.440650000000005 55.440650000000005 2.6107089468186477 284.572 284.572 251.79082528559294 74.6342;154.987 57.2867;53.5946 106.529;462.615 3 25333;59107;24330 MGP_33209;LTBP1_33264;EGR1_8533 360.71361666666667 75.1005 553.588711967753 174.19799333333333 13.9312 288.40823638284695 1819.3520666666666 346.231 2815.617411128084 75.1005;998.777;8.26335 13.9312;507.146;1.51678 346.231;5065.92;45.9052 0 Exp 2,1(0.2);Exp 4,1(0.2);Hill,2(0.4);Poly 2,1(0.2) 2.462878513271987 13.54650616645813 1.6427439451217651 5.289852619171143 1.4865448918151163 2.0189225673675537 -101.36126875245702 626.0660887524571 -60.93817394142914 314.32828594142916 -692.0920935533964 3102.9721735533963 DOWN 0.4 0.6 0.0 GO:0043086 5 negative regulation of catalytic activity 212 228 11 11 5 6 3 3 49 225 2270 0.30175 0.85841 0.62165 1.32 246273;299270;24314 trib3;serpina6;nqo1 TRIB3_10079;SERPINA6_32325;NQO1_33055 18.951333333333334 16.8949 15.8474 4.499594666559791 20.399363907911994 4.631232886878225 10.210963333333334 7.7531 6.46469 5.411421616916698 11.703526111030161 5.876382441858798 45.6235 40.8362 37.0434 11.730808583810443 45.155354189130115 12.368073118898355 16.8949;15.8474;24.1117 6.46469;7.7531;16.4151 58.9909;40.8362;37.0434 2 1 2 246273;24314 TRIB3_10079;NQO1_33055 20.5033 20.5033 5.103048218467077 11.439895 11.439895 7.03600238658643 48.01715 48.01715 15.519226080091789 16.8949;24.1117 6.46469;16.4151 58.9909;37.0434 1 299270 SERPINA6_32325 15.8474 15.8474 7.7531 7.7531 40.8362 40.8362 15.8474 7.7531 40.8362 0 Exp 4,3(1) 2.69805714186878 8.856098175048828 1.8130581378936768 4.773829460144043 1.59412241374991 2.2692105770111084 13.859562637047633 24.043104029619037 4.087363307971519 16.33456335869515 32.34884043239717 58.89815956760283 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0071285 7 cellular response to lithium ion 14 15 2 2 2 2 2 2 50 13 2482 0.99693 0.03623 0.03623 13.33 25587;300850 id2;gsta4 ID2_8861;GSTA4_8757 54.17587 54.17587 2.99674 72.37821975645574 59.435339847087924 71.99501822326978 38.320372 38.320372 0.998544 52.78103533015593 42.15578360242861 52.501589749293124 91.47749999999999 91.47749999999999 10.914 113.93399433224485 99.75668135821903 113.33077859335228 0.0 2.99674 0.5 54.17587 2.99674;105.355 0.998544;75.6422 10.914;172.041 2 0 2 25587;300850 ID2_8861;GSTA4_8757 54.17587 54.17587 72.37821975645574 38.320372 38.320372 52.78103533015593 91.47749999999999 91.47749999999999 113.93399433224485 2.99674;105.355 0.998544;75.6422 10.914;172.041 0 0 Hill,1(0.5);Poly 2,1(0.5) 2.0238204158971063 4.048714756965637 1.9777342081069946 2.0709805488586426 0.06593511986632178 2.0243573784828186 -46.135224799999975 154.48696479999998 -34.83041087999999 111.47115488 -66.42696 249.38196 UP 1.0 0.0 0.0 GO:0050790 4 regulation of catalytic activity 528 565 18 18 9 10 6 6 46 559 1936 0.038072 0.98493 0.06421 1.06 246273;299270;24314;24484;24330;58919 trib3;serpina6;nqo1;igfbp3;egr1;ccnd1 TRIB3_10079;SERPINA6_32325;NQO1_33055;IGFBP3_8881;EGR1_8533;CCND1_8224 103.792275 20.5033 8.26335 200.72899755875764 142.8169510859386 225.9704418749774 63.508195 12.0841 1.51678 130.7256967770961 87.52177617634347 147.98403932694967 218.01678333333334 52.44805 37.0434 385.6518933750406 297.66649712577436 431.26675788822007 16.8949;15.8474;24.1117;44.9033;8.26335;512.733 6.46469;7.7531;16.4151;18.8755;1.51678;330.024 58.9909;40.8362;37.0434;122.765;45.9052;1002.56 2 4 2 246273;24314 TRIB3_10079;NQO1_33055 20.5033 20.5033 5.103048218467077 11.439895 11.439895 7.03600238658643 48.01715 48.01715 15.519226080091789 16.8949;24.1117 6.46469;16.4151 58.9909;37.0434 4 299270;24484;24330;58919 SERPINA6_32325;IGFBP3_8881;EGR1_8533;CCND1_8224 145.4367625 30.37535 245.37281235835593 89.542345 13.3143 160.4817851190931 303.0166 84.3351 467.8662351357276 15.8474;44.9033;8.26335;512.733 7.7531;18.8755;1.51678;330.024 40.8362;122.765;45.9052;1002.56 0 Exp 2,1(0.17);Exp 4,4(0.67);Hill,1(0.17) 2.5382531754678745 17.356241703033447 1.555469274520874 5.289852619171143 1.6828477766913028 2.0411343574523926 -56.824374395780026 264.40892439578005 -41.094147768735745 168.11053776873572 -90.5689999883108 526.6025666549774 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0010629 7 negative regulation of gene expression 355 375 21 19 9 14 7 7 45 368 2127 0.49352 0.66268 1.0 1.87 24522;246273;24614;25587;24330;25695;58919 zfp354a;trib3;orm1;id2;egr1;cebpd;ccnd1 ZFP354A_10203;TRIB3_10079;ORM1_9400;ID2_8861;EGR1_8533;CEBPD_8283;CCND1_8224 86.6853957142857 8.26335 2.99674 188.83282807010073 105.67900101301623 201.62496819977412 51.28043342857143 2.15795 0.998544 123.03073479865971 61.924999630987614 132.09181268525876 200.62475714285713 45.9052 6.6682 364.8181574500912 249.91080987874184 385.8434728416871 3.26713;16.8949;56.9823;2.99674;8.26335;5.66035;512.733 1.71987;6.46469;16.0812;0.998544;1.51678;2.15795;330.024 6.6682;58.9909;262.985;10.914;45.9052;16.35;1002.56 3 4 3 246273;24614;25587 TRIB3_10079;ORM1_9400;ID2_8861 25.624646666666667 16.8949 28.031527424964438 7.848144666666666 6.46469 7.6359078120826815 110.9633 58.9909 133.83121844909732 16.8949;56.9823;2.99674 6.46469;16.0812;0.998544 58.9909;262.985;10.914 4 24522;24330;25695;58919 ZFP354A_10203;EGR1_8533;CEBPD_8283;CCND1_8224 132.4809575 6.96185 253.50957216793915 83.85465 1.93891 164.11311809449987 267.87084999999996 31.1276 490.0770209056905 3.26713;8.26335;5.66035;512.733 1.71987;1.51678;2.15795;330.024 6.6682;45.9052;16.35;1002.56 0 Exp 2,1(0.15);Exp 4,4(0.58);Hill,2(0.29) 2.4936926556333985 20.750054001808167 1.555469274520874 6.495501518249512 2.047157248173253 1.9777342081069946 -53.203920968495254 226.57471239706666 -39.86201038197085 142.4228772391137 -69.63631600179198 470.8858302875062 CONFLICT 0.42857142857142855 0.5714285714285714 0.0 GO:0031398 10 positive regulation of protein ubiquitination 34 35 4 2 2 2 2 2 50 33 2462 0.96682 0.15908 0.15908 5.71 246273;363140 trib3;rassf1 TRIB3_10079;RASSF1_32475 386.73795 386.73795 16.8949 523.0370572594306 611.8211363297123 415.02154369373767 221.982345 221.982345 6.46469 304.7879906318457 353.14447038726263 241.84439824232032 499.58895 499.58895 58.9909 623.099737865139 767.7329991707439 494.41968115786034 0.5 386.73795 16.8949;756.581 6.46469;437.5 58.9909;940.187 2 0 2 246273;363140 TRIB3_10079;RASSF1_32475 386.73795 386.73795 523.0370572594306 221.982345 221.982345 304.7879906318457 499.58895 499.58895 623.099737865139 16.8949;756.581 6.46469;437.5 58.9909;940.187 0 0 Exp 4,1(0.5);Poly 2,1(0.5) 2.2316387638718544 4.463899612426758 2.1946890354156494 2.2692105770111084 0.05269468740662442 2.231949806213379 -338.154428 1111.630328 -200.43225879999997 644.3969487999999 -363.98322799999977 1363.1611279999997 UP 1.0 0.0 0.0 GO:0035239 4 tube morphogenesis 83 86 3 3 3 2 2 2 50 84 2411 0.74437 0.53012 0.69467 2.33 25333;25587 mgp;id2 MGP_33209;ID2_8861 39.04862 39.04862 2.99674 50.98505764504733 62.25701774999999 39.01559496950404 7.464872000000001 7.464872000000001 0.998544 9.14476875635289 11.627570650000001 6.997905079789548 178.5725 178.5725 10.914 237.10492454712954 286.50265937499995 181.4411933356762 75.1005;2.99674 13.9312;0.998544 346.231;10.914 1 1 1 25587 ID2_8861 2.99674 2.99674 0.998544 0.998544 10.914 10.914 2.99674 0.998544 10.914 1 25333 MGP_33209 75.1005 75.1005 13.9312 13.9312 346.231 346.231 75.1005 13.9312 346.231 0 Hill,2(1) 1.9982222661661062 3.9966567754745483 1.9777342081069946 2.0189225673675537 0.02912456813908906 1.9983283877372742 -31.61306479999999 109.71030479999999 -5.209130879999997 20.13887488 -150.03816 507.18316 CONFLICT 0.5 0.5 0.0 GO:1901362 5 organic cyclic compound biosynthetic process 212 234 19 17 8 13 4 4 48 230 2265 0.47216 0.71817 1.0 1.71 297417;24330;24296;64392 gfpt1;egr1;cyp1a1;aldh1l1 GFPT1_8705;EGR1_8533;CYP1A1_8415;ALDH1L1_32662 318.6755875 142.4695 8.26335 447.6768476853 135.70215701655383 242.9731480494195 185.22592 92.25845 1.51678 250.5898232667565 85.56417791895089 136.924465339013 1398.96005 654.7275 45.9052 1958.186713512276 492.86528245727186 1118.9356009680957 981.5;8.26335;100.909;184.03 554.87;1.51678;73.3629;111.154 4240.48;45.9052;159.385;1150.07 3 1 3 297417;24296;64392 GFPT1_8705;CYP1A1_8415;ALDH1L1_32662 422.14633333333336 184.03 486.19406461857733 246.4623 111.154 267.75646373947734 1849.9783333333332 1150.07 2128.670443271652 981.5;100.909;184.03 554.87;73.3629;111.154 4240.48;159.385;1150.07 1 24330 EGR1_8533 8.26335 8.26335 1.51678 1.51678 45.9052 45.9052 8.26335 1.51678 45.9052 0 Hill,1(0.25);Linear,1(0.25);Poly 2,2(0.5) 2.280640496104126 10.480647206306458 1.5232417583465576 5.289852619171143 1.786782541109916 1.8337764143943787 -120.04772323159398 757.398898231594 -60.35210680142137 430.8039468014214 -520.0629292420306 3317.98302924203 UP 0.75 0.25 0.0 GO:0001101 4 response to acid chemical 195 202 16 15 9 11 7 7 45 195 2300 0.95063 0.11309 0.18565 3.47 24522;24614;24314;24539;24330;25612;24188 zfp354a;orm1;nqo1;lpl;egr1;asns;aldh1a1 ZFP354A_10203;ORM1_9400;NQO1_33055;LPL_32544;EGR1_8533;ASNS_8091;ALDH1A1_8022 157.9361971428571 56.9823 3.26713 274.82875815308984 198.59553283261204 318.734787183318 85.64103571428572 16.4151 1.51678 160.0716687352764 110.69666991460507 186.0306186050892 447.4316857142857 133.645 6.6682 782.0252012317067 569.0690493161463 902.7512503447849 3.26713;56.9823;24.1117;769.435;8.26335;154.987;88.5069 1.71987;16.0812;16.4151;444.211;1.51678;53.5946;65.9487 6.6682;262.985;37.0434;2183.16;45.9052;462.615;133.645 4 3 4 24614;24314;25612;24188 ORM1_9400;NQO1_33055;ASNS_8091;ALDH1A1_8022 81.146975 72.7446 55.80762164253045 38.0099 35.00485 25.62981785772189 224.0721 198.315 184.00518467778744 56.9823;24.1117;154.987;88.5069 16.0812;16.4151;53.5946;65.9487 262.985;37.0434;462.615;133.645 3 24522;24539;24330 ZFP354A_10203;LPL_32544;EGR1_8533 260.32182666666665 8.26335 440.91201843420487 149.14921666666666 1.71987 255.53102022899733 745.2444666666667 45.9052 1245.4259095960758 3.26713;769.435;8.26335 1.71987;444.211;1.51678 6.6682;2183.16;45.9052 0 Exp 2,1(0.15);Exp 4,4(0.58);Hill,1(0.15);Poly 2,1(0.15) 3.1732043885600465 25.2674480676651 1.5846891403198242 6.495501518249512 1.9104807139331301 2.79919695854187 -45.65979607364426 361.53219035935854 -32.9417159634975 204.2237873920689 -131.90069069012884 1026.7640621187004 CONFLICT 0.5714285714285714 0.42857142857142855 0.0 GO:0008211 5 glucocorticoid metabolic process 8 9 2 2 1 2 1 1 51 8 2487 0.98657 0.16968 0.16968 11.11 299270 serpina6 SERPINA6_32325 15.8474 15.8474 15.8474 15.847400000000002 7.7531 7.7531 7.7531 7.753100000000001 40.8362 40.8362 40.8362 40.8362 0.0 15.8474 0.0 15.8474 15.8474 7.7531 40.8362 0 1 0 1 299270 SERPINA6_32325 15.8474 15.8474 7.7531 7.7531 40.8362 40.8362 15.8474 7.7531 40.8362 0 Exp 4,1(1) 1.8130581378936768 1.8130581378936768 1.8130581378936768 1.8130581378936768 0.0 1.8130581378936768 15.8474 15.8474 7.7531 7.7531 40.8362 40.8362 DOWN 0.0 1.0 0.0 GO:1901342 6 regulation of vasculature development 120 124 3 3 3 3 3 3 49 121 2374 0.75458 0.46895 0.73903 2.42 360918;83619;24330 pf4;nfe2l2;egr1 PF4_32963;NFE2L2_9301;EGR1_8533 64.84555 8.26335 6.6423 99.41041997473152 25.875313980245878 64.92823122591015 38.57269333333333 3.4063 1.51678 62.55348716616952 13.81623576337081 40.96235793733834 162.01683333333332 45.9052 13.4683 229.77552303372818 74.4974364925922 149.8460707012476 179.631;6.6423;8.26335 110.795;3.4063;1.51678 426.677;13.4683;45.9052 2 1 2 360918;83619 PF4_32963;NFE2L2_9301 93.13665 93.13665 122.3214828386453 57.10065 57.10065 75.93527799280778 220.07265 220.07265 292.1826738152778 179.631;6.6423 110.795;3.4063 426.677;13.4683 1 24330 EGR1_8533 8.26335 8.26335 1.51678 1.51678 45.9052 45.9052 8.26335 1.51678 45.9052 0 Exp 4,1(0.34);Hill,1(0.34);Poly 2,1(0.34) 2.4757038788281864 8.692013025283813 1.5423688888549805 5.289852619171143 2.07804838718392 1.8597915172576904 -47.64793015602339 177.3390301560234 -32.213241068776696 109.35862773544336 -97.99864841701827 422.032315083685 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0043651 8 linoleic acid metabolic process 10 12 3 3 3 2 2 2 50 10 2485 0.99845 0.023677 0.023677 16.67 24424;499353 gstm2;cyp2c24 GSTM2_8759;CYP2C24_32875 368.60884 368.60884 3.28268 516.6492101616832 653.4309827393535 323.54149713972964 232.00703850000002 232.00703850000002 0.808077 326.96470695987506 412.2585255918176 204.75527441248872 888.4337 888.4337 13.1174 1237.8841828262368 1570.8635159778173 775.2008401829447 0.0 3.28268 0.5 368.60884 3.28268;733.935 0.808077;463.206 13.1174;1763.75 1 1 1 24424 GSTM2_8759 3.28268 3.28268 0.808077 0.808077 13.1174 13.1174 3.28268 0.808077 13.1174 1 499353 CYP2C24_32875 733.935 733.935 463.206 463.206 1763.75 1763.75 733.935 463.206 1763.75 0 Hill,1(0.5);Linear,1(0.5) 1.7052487647676113 3.410497784614563 1.7045893669128418 1.7059084177017212 9.327097575460849E-4 1.7052488923072815 -347.4304335999998 1084.6481135999998 -221.14292603999994 685.15700304 -827.1862479999999 2604.0536479999996 CONFLICT 0.5 0.5 0.0 GO:0051093 5 negative regulation of developmental process 252 270 13 13 8 9 6 6 46 264 2231 0.68971 0.47884 0.81885 2.22 246273;360918;83619;29200;25587;58919 trib3;pf4;nfe2l2;inhba;id2;ccnd1 TRIB3_10079;PF4_32963;NFE2L2_9301;INHBA_33300;ID2_8861;CCND1_8224 141.51099 73.53145 2.99674 196.1083935864281 218.01845349408106 247.7075719581664 90.142089 47.814345 0.998544 126.84037718952314 140.08661668103213 159.98200052388813 290.6567 145.16045 10.914 384.0796579053257 430.74402469587034 481.80102253905096 16.8949;179.631;6.6423;130.168;2.99674;512.733 6.46469;110.795;3.4063;89.164;0.998544;330.024 58.9909;426.677;13.4683;231.33;10.914;1002.56 4 2 4 246273;360918;83619;25587 TRIB3_10079;PF4_32963;NFE2L2_9301;ID2_8861 51.541235 11.7686 85.59563615361611 30.4161335 4.9354949999999995 53.632575621061825 127.51255 36.229600000000005 200.66215178975995 16.8949;179.631;6.6423;2.99674 6.46469;110.795;3.4063;0.998544 58.9909;426.677;13.4683;10.914 2 29200;58919 INHBA_33300;CCND1_8224 321.4505 321.4505 270.51430574463154 209.594 209.594 170.31373931659186 616.9449999999999 616.9449999999999 545.341962854501 130.168;512.733 89.164;330.024 231.33;1002.56 0 Exp 2,1(0.17);Exp 4,2(0.34);Hill,1(0.17);Poly 2,2(0.34) 1.788732479938318 10.840319752693176 1.5423688888549805 2.2692105770111084 0.2857274115885187 1.7477684020996094 -15.4084061974564 298.4303861974564 -11.351350612852201 191.6355286128522 -16.67103293391733 597.9844329339173 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0051384 7 response to glucocorticoid 119 133 9 9 5 7 5 5 47 128 2367 0.94886 0.13206 0.19179 3.76 286954;24614;25333;25315;58919 ugt2b1;orm1;mgp;ephx1;ccnd1 UGT2B10_33303,UGT2B1_33224;ORM1_9400;MGP_33209;EPHX1_8567;CCND1_8224 139.03816 56.9823 24.8784 209.99592771035583 153.0750367967398 209.6195285161332 77.37246 15.4867 11.3392 141.24840831329038 81.40713522324822 144.31442500767358 343.42665 262.985 41.3795 390.5955917090591 405.48928884405774 363.94797044770417 25.4966;56.9823;75.1005;24.8784;512.733 11.3392;16.0812;13.9312;15.4867;330.024 63.97775;262.985;346.231;41.3795;1002.56 4 2 3 286954;24614;25315 UGT2B10_33303,UGT2B1_33224;ORM1_9400;EPHX1_8567 35.78576666666667 25.4966 18.359338545365212 14.302366666666666 15.4867 2.5833360376329906 122.78075000000001 63.97775 121.94504505847091 25.4966;56.9823;24.8784 11.3392;16.0812;15.4867 63.97775;262.985;41.3795 2 25333;58919 MGP_33209;CCND1_8224 293.91675 293.91675 309.45290841762176 171.9776 171.9776 223.51136236424315 674.3955 674.3955 464.09468658938556 75.1005;512.733 13.9312;330.024 346.231;1002.56 0 Exp 2,1(0.17);Exp 4,4(0.67);Hill,1(0.17) 1.833203243584054 11.197382092475891 1.555469274520874 2.6370131969451904 0.41185057418800936 1.7006439566612244 -45.03138638852701 323.10770638852705 -46.437228739248184 201.1821487392482 1.0545184489020016 685.798781551098 UP 0.6 0.4 0.0 GO:0072521 5 purine-containing compound metabolic process 83 95 8 5 3 5 3 3 49 92 2403 0.87343 0.30633 0.44206 3.16 266730;24763;296925 slc17a3;acsm3;aass SLC17A3_9840;ACSM3_7976;AASS_7936 182.48573333333334 58.7587 28.5735 240.91587405391812 144.98211317604554 220.10776011648568 128.20397333333332 46.6655 6.14642 177.47945097067472 100.41382469126341 162.61269854751302 318.5444333333333 128.079 78.8953 373.30103727496305 261.94912943398293 340.03889125689966 58.7587;460.125;28.5735 46.6655;331.8;6.14642 78.8953;748.659;128.079 1 2 1 266730 SLC17A3_9840 58.7587 58.7587 46.6655 46.6655 78.8953 78.8953 58.7587 46.6655 78.8953 2 24763;296925 ACSM3_7976;AASS_7936 244.34925 244.34925 305.15299208122633 168.97321 168.97321 230.27185473567587 438.369 438.369 438.8163262687475 460.125;28.5735 331.8;6.14642 748.659;128.079 0 Hill,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 1.6758041240255077 5.033449411392212 1.6175053119659424 1.7953243255615234 0.10177670153543368 1.620619773864746 -90.13624235135057 455.1077090180172 -72.63293190201688 329.0408785686836 -103.88545721122085 740.9743238778876 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0006732 5 coenzyme metabolic process 61 67 9 7 3 7 3 3 49 64 2431 0.954 0.15511 0.15511 4.48 64392;24763;296925 aldh1l1;acsm3;aass ALDH1L1_32662;ACSM3_7976;AASS_7936 224.24283333333332 184.03 28.5735 218.56801747186924 192.08298142847167 231.81804373804596 149.70014 111.154 6.14642 166.2134688386558 127.23931068630874 175.15024140492736 675.6026666666667 748.659 128.079 514.8973896810248 512.049234587726 500.98663532742347 184.03;460.125;28.5735 111.154;331.8;6.14642 1150.07;748.659;128.079 1 2 1 64392 ALDH1L1_32662 184.03 184.03 111.154 111.154 1150.07 1150.07 184.03 111.154 1150.07 2 24763;296925 ACSM3_7976;AASS_7936 244.34925 244.34925 305.15299208122633 168.97321 168.97321 230.27185473567587 438.369 438.369 438.8163262687475 460.125;28.5735 331.8;6.14642 748.659;128.079 0 Hill,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 1.6651682989168841 4.999482750892639 1.6175053119659424 1.7613576650619507 0.08216888440159283 1.620619773864746 -23.090161964974612 471.57582863164134 -38.388106314801206 337.7883863148012 92.94141945341084 1258.2639138799225 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0046483 4 heterocycle metabolic process 413 462 32 29 16 22 11 11 41 451 2044 0.77881 0.33749 0.58487 2.38 266730;83619;307126;297417;25315;24330;24296;64392;26760;24763;296925 slc17a3;nfe2l2;mcm10;gfpt1;ephx1;egr1;cyp1a1;aldh1l1;akr7a3;acsm3;aass SLC17A3_9840;NFE2L2_9301;MCM10_32579;GFPT1_8705;EPHX1_8567;EGR1_8533;CYP1A1_8415;ALDH1L1_32662;AKR7A3_8015;ACSM3_7976;AASS_7936 189.73985000000002 58.7587 6.6423 295.6545935883248 126.51118670831922 178.12479952898045 116.39841818181817 46.6655 1.51678 174.49363876373866 81.00184895131821 113.85561189000356 664.2518818181817 128.079 13.4683 1245.4202786471992 351.3441882778659 647.4201977052907 58.7587;6.6423;213.608;981.5;24.8784;8.26335;100.909;184.03;19.8501;460.125;28.5735 46.6655;3.4063;123.177;554.87;15.4867;1.51678;73.3629;111.154;12.797;331.8;6.14642 78.8953;13.4683;668.095;4240.48;41.3795;45.9052;159.385;1150.07;32.3544;748.659;128.079 7 4 7 266730;83619;297417;25315;24296;64392;26760 SLC17A3_9840;NFE2L2_9301;GFPT1_8705;EPHX1_8567;CYP1A1_8415;ALDH1L1_32662;AKR7A3_8015 196.65264285714284 58.7587 351.4720827732167 116.82034285714285 46.6655 196.9272154170237 816.5760714285714 78.8953 1563.72017872996 58.7587;6.6423;981.5;24.8784;100.909;184.03;19.8501 46.6655;3.4063;554.87;15.4867;73.3629;111.154;12.797 78.8953;13.4683;4240.48;41.3795;159.385;1150.07;32.3544 4 307126;24330;24763;296925 MCM10_32579;EGR1_8533;ACSM3_7976;AASS_7936 177.6424625 121.09075 209.76236015406965 115.66005000000001 64.66171 154.6985280746338 397.68455 398.087 361.819816897504 213.608;8.26335;460.125;28.5735 123.177;1.51678;331.8;6.14642 668.095;45.9052;748.659;128.079 0 Exp 4,3(0.28);Hill,2(0.19);Linear,2(0.19);Poly 2,4(0.37) 2.1479615526167666 25.91891348361969 1.5232417583465576 5.289852619171143 1.2320168601923596 1.7953243255615234 15.019150474920167 364.46054952507984 13.279267359732216 219.51756900390416 -71.74447002930515 1400.2482336656687 UP 0.6363636363636364 0.36363636363636365 0.0 GO:0032496 5 response to lipopolysaccharide 176 189 14 13 7 10 6 6 46 183 2312 0.91372 0.18445 0.27595 3.17 286954;360918;24614;24484;24296;140668 ugt2b1;pf4;orm1;igfbp3;cyp1a1;abcc3 UGT2B10_33303,UGT2B1_33224;PF4_32963;ORM1_9400;IGFBP3_8881;CYP1A1_8415;ABCC3_7941 82.40235 71.7371 25.4966 54.96044572274684 70.19174440554846 33.726668729722135 45.1506 29.66265 11.3392 39.511619328040716 36.79909560926654 28.629986167855794 190.63495833333332 141.075 63.97775 133.71652468304146 160.86409051780785 83.6320543391904 25.4966;179.631;56.9823;44.9033;100.909;86.4919 11.3392;110.795;16.0812;18.8755;73.3629;40.4498 63.97775;426.677;262.985;122.765;159.385;108.02 6 1 5 286954;360918;24614;24296;140668 UGT2B10_33303,UGT2B1_33224;PF4_32963;ORM1_9400;CYP1A1_8415;ABCC3_7941 89.90216000000001 86.4919 57.91338029577447 50.40562 40.4498 41.76536619499462 204.20895000000002 159.385 144.804132687529 25.4966;179.631;56.9823;100.909;86.4919 11.3392;110.795;16.0812;73.3629;40.4498 63.97775;426.677;262.985;159.385;108.02 1 24484 IGFBP3_8881 44.9033 44.9033 18.8755 18.8755 122.765 122.765 44.9033 18.8755 122.765 0 Exp 4,4(0.58);Exp 5,1(0.15);Poly 2,2(0.29) 1.9036098524552647 13.775719285011292 1.5846891403198242 3.368933916091919 0.6279754390161773 1.7026138305664062 38.424834301491074 126.37986569850892 13.534719953502165 76.76648004649783 83.63945482043697 297.6304618462297 UP 0.8333333333333334 0.16666666666666666 0.0 GO:0019216 6 regulation of lipid metabolic process 132 142 13 13 5 11 4 4 48 138 2357 0.83911 0.32907 0.53212 2.82 246273;25587;246248;24330 trib3;id2;fmo5;egr1 TRIB3_10079;ID2_8861;FMO5_33281;EGR1_8533 21.4131975 12.579125000000001 2.99674 24.729186170758325 20.929765794369843 24.292704524794566 10.1322285 3.990735 0.998544 14.488786493809469 9.617322337809417 14.446144948901065 56.209025 52.44805 10.914 40.64143934478494 57.97240530658469 37.32936081233847 16.8949;2.99674;57.4978;8.26335 6.46469;0.998544;31.5489;1.51678 58.9909;10.914;109.026;45.9052 3 1 3 246273;25587;246248 TRIB3_10079;ID2_8861;FMO5_33281 25.79648 16.8949 28.319957276683876 13.004044666666667 6.46469 16.29120721506007 59.643633333333334 58.9909 49.05925683908525 16.8949;2.99674;57.4978 6.46469;0.998544;31.5489 58.9909;10.914;109.026 1 24330 EGR1_8533 8.26335 8.26335 1.51678 1.51678 45.9052 45.9052 8.26335 1.51678 45.9052 0 Exp 4,1(0.25);Exp 5,1(0.25);Hill,2(0.5) 2.513478808832847 11.217978954315186 1.68118155002594 5.289852619171143 1.67420612257178 2.1234723925590515 -2.8214049473431615 45.64779994734316 -4.066782263933279 24.331239263933277 16.380414442110755 96.03763555788925 UP 0.75 0.25 0.0 GO:0019373 7 epoxygenase P450 pathway 10 13 3 3 2 3 2 2 50 11 2484 0.99801 0.027621 0.027621 15.38 499353;29277 cyp2c24;cyp2c11 CYP2C24_32875;CYP2C11_32593 431.93449999999996 431.93449999999996 129.934 427.0932029434558 630.3163189478812 322.0216014840621 254.25830000000002 254.25830000000002 45.3106 295.4966711666647 391.51444623477846 222.79987278302966 1059.4465 1059.4465 355.143 996.0355617268393 1522.0980830979056 750.9952500106128 0.0 129.934 0.5 431.93449999999996 733.935;129.934 463.206;45.3106 1763.75;355.143 0 2 0 2 499353;29277 CYP2C24_32875;CYP2C11_32593 431.93449999999996 431.93449999999996 427.0932029434558 254.25830000000002 254.25830000000002 295.4966711666647 1059.4465 1059.4465 996.0355617268393 733.935;129.934 463.206;45.3106 1763.75;355.143 0 Exp 4,1(0.5);Linear,1(0.5) 1.6663212885860665 3.333501696586609 1.628912329673767 1.7045893669128418 0.05351174621185661 1.6667508482933044 -159.98648000000003 1023.85548 -155.2791919999999 663.7957919999999 -320.98835999999983 2439.88136 DOWN 0.0 1.0 0.0 GO:1901360 4 organic cyclic compound metabolic process 507 567 43 40 21 33 16 16 36 551 1944 0.94707 0.096094 0.17582 2.82 286954;24902;266730;299270;501907;83619;307126;24424;297417;25315;24330;24296;64392;26760;24763;296925 ugt2b1;sult2a6;slc17a3;serpina6;rgd1559459;nfe2l2;mcm10;gstm2;gfpt1;ephx1;egr1;cyp1a1;aldh1l1;akr7a3;acsm3;aass UGT2B10_33303,UGT2B1_33224;SULT2A6_32471,SULT2A6_9972;SLC17A3_9840;SERPINA6_32325;RGD1559459_9690;NFE2L2_9301;MCM10_32579;GSTM2_8759;GFPT1_8705;EPHX1_8567;EGR1_8533;CYP1A1_8415;ALDH1L1_32662;AKR7A3_8015;ACSM3_7976;AASS_7936 139.06703625 35.67675 3.28268 253.77031738832738 101.71353059704454 154.3132812479559 83.8597423125 18.0466 0.808077 151.0065964126557 63.05560190589621 99.55295322554761 479.542240625 86.25405 13.1174 1055.8852277275973 280.2707632227861 553.2381093533817 25.4966;50.527550000000005;58.7587;15.8474;42.78;6.6423;213.608;3.28268;981.5;24.8784;8.26335;100.909;184.03;19.8501;460.125;28.5735 11.3392;20.8664;46.6655;7.7531;20.6065;3.4063;123.177;0.808077;554.87;15.4867;1.51678;73.3629;111.154;12.797;331.8;6.14642 63.97775;154.361;78.8953;40.8362;93.6128;13.4683;668.095;13.1174;4240.48;41.3795;45.9052;159.385;1150.07;32.3544;748.659;128.079 13 5 11 286954;24902;266730;501907;83619;24424;297417;25315;24296;64392;26760 UGT2B10_33303,UGT2B1_33224;SULT2A6_32471,SULT2A6_9972;SLC17A3_9840;RGD1559459_9690;NFE2L2_9301;GSTM2_8759;GFPT1_8705;EPHX1_8567;CYP1A1_8415;ALDH1L1_32662;AKR7A3_8015 136.24139363636365 42.78 285.0906359355443 79.21477972727273 20.6065 161.29953096797405 549.1910409090908 78.8953 1267.203111066704 25.4966;50.527550000000005;58.7587;42.78;6.6423;3.28268;981.5;24.8784;100.909;184.03;19.8501 11.3392;20.8664;46.6655;20.6065;3.4063;0.808077;554.87;15.4867;73.3629;111.154;12.797 63.97775;154.361;78.8953;93.6128;13.4683;13.1174;4240.48;41.3795;159.385;1150.07;32.3544 5 299270;307126;24330;24763;296925 SERPINA6_32325;MCM10_32579;EGR1_8533;ACSM3_7976;AASS_7936 145.28345 28.5735 195.53954651918878 94.07866 7.7531 142.3991148603256 326.31488 128.079 351.6437599394478 15.8474;213.608;8.26335;460.125;28.5735 7.7531;123.177;1.51678;331.8;6.14642 40.8362;668.095;45.9052;748.659;128.079 0 Exp 4,9(0.5);Hill,3(0.17);Linear,2(0.12);Poly 2,4(0.23) 2.0105099640119497 38.656912207603455 1.5232417583465576 5.289852619171143 0.9885681051521052 1.778340995311737 14.719580729719567 263.41449177028045 9.866510070298688 157.85297455470132 -37.841520961522804 996.9260022115229 UP 0.6875 0.3125 0.0 GO:0043066 8 negative regulation of apoptotic process 279 296 10 10 6 6 4 4 48 292 2203 0.25996 0.87121 0.51171 1.35 360918;24314;83619;25612 pf4;nqo1;nfe2l2;asns PF4_32963;NQO1_33055;NFE2L2_9301;ASNS_8091 91.34299999999999 89.54935 6.6423 88.58063362492581 67.14574498051587 81.45487975463583 46.05275 35.00485 3.4063 48.116346604212026 30.752019669697535 37.32084505774876 234.950925 231.86020000000002 13.4683 242.76996005068085 176.81713148079425 236.78807540927568 179.631;24.1117;6.6423;154.987 110.795;16.4151;3.4063;53.5946 426.677;37.0434;13.4683;462.615 4 0 4 360918;24314;83619;25612 PF4_32963;NQO1_33055;NFE2L2_9301;ASNS_8091 91.34299999999999 89.54935 88.58063362492581 46.05275 35.00485 48.116346604212026 234.950925 231.86020000000002 242.76996005068085 179.631;24.1117;6.6423;154.987 110.795;16.4151;3.4063;53.5946 426.677;37.0434;13.4683;462.615 0 0 Exp 4,3(0.75);Poly 2,1(0.25) 2.4506997100029095 10.810142755508423 1.5423688888549805 4.773829460144043 1.4550073123351066 2.2469722032546997 4.533979047572743 178.15202095242728 -1.101269672127799 93.20676967212779 -2.963635849667213 472.86548584966727 UP 1.0 0.0 0.0 GO:1901137 5 carbohydrate derivative biosynthetic process 71 78 7 5 2 5 2 2 50 76 2419 0.78817 0.47752 0.67267 2.56 305291;297417 srd5a3;gfpt1 SRD5A3_9939;GFPT1_8705 575.3545 575.3545 169.209 574.3764743968019 283.206849396755 399.0085648635986 330.2085 330.2085 105.547 317.7193402430831 168.6055045070032 220.7136671343234 2349.8455 2349.8455 459.211 2673.7609513904745 989.8786227985022 1857.4115890157766 169.209;981.5 105.547;554.87 459.211;4240.48 2 0 2 305291;297417 SRD5A3_9939;GFPT1_8705 575.3545 575.3545 574.3764743968019 330.2085 330.2085 317.7193402430831 2349.8455 2349.8455 2673.7609513904745 169.209;981.5 105.547;554.87 459.211;4240.48 0 0 Linear,1(0.5);Poly 2,1(0.5) 1.5276710961160345 3.0553550720214844 1.5232417583465576 1.5321133136749268 0.006273136932361468 1.5276775360107422 -220.69068000000004 1371.39968 -110.12803999999994 770.5450399999999 -1355.7981199999995 6055.489119999998 UP 1.0 0.0 0.0 GO:0051726 5 regulation of cell cycle 252 268 10 9 7 7 6 6 46 262 2233 0.69649 0.47134 0.81808 2.24 363140;29200;25587;24296;58919;25612 rassf1;inhba;id2;cyp1a1;ccnd1;asns RASSF1_32475;INHBA_33300;ID2_8861;CYP1A1_8415;CCND1_8224;ASNS_8091 276.39579 142.5775 2.99674 292.60841669243996 369.6060915269744 318.61048885855007 164.10734066666666 81.26345 0.998544 176.0343643971697 222.7786566751269 185.75088846864313 467.83183333333335 346.9725 10.914 416.8758337046736 568.8050670818085 429.8390428704609 756.581;130.168;2.99674;100.909;512.733;154.987 437.5;89.164;0.998544;73.3629;330.024;53.5946 940.187;231.33;10.914;159.385;1002.56;462.615 4 2 4 363140;25587;24296;25612 RASSF1_32475;ID2_8861;CYP1A1_8415;ASNS_8091 253.868435 127.94800000000001 340.99396734851024 141.364011 63.47875 199.7720441834121 393.27525 311.0 410.2134557214288 756.581;2.99674;100.909;154.987 437.5;0.998544;73.3629;53.5946 940.187;10.914;159.385;462.615 2 29200;58919 INHBA_33300;CCND1_8224 321.4505 321.4505 270.51430574463154 209.594 209.594 170.31373931659186 616.9449999999999 616.9449999999999 545.341962854501 130.168;512.733 89.164;330.024 231.33;1002.56 0 Exp 2,1(0.17);Exp 4,1(0.17);Hill,1(0.17);Poly 2,3(0.5) 1.9527848446679088 11.903985857963562 1.555469274520874 2.634152889251709 0.3944873710414665 1.9419646859169006 42.26029365554837 510.5312863444516 23.250513143713647 304.96416818961967 134.26169429989739 801.4019723667694 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0006954 5 inflammatory response 129 140 4 4 3 3 3 3 49 137 2358 0.6804 0.55201 0.76173 2.14 360918;24614;83619 pf4;orm1;nfe2l2 PF4_32963;ORM1_9400;NFE2L2_9301 81.0852 56.9823 6.6423 88.97744052977697 53.25634369717283 51.0390093084603 43.4275 16.0812 3.4063 58.68516264516953 19.845384982512385 32.11067707786021 234.37676666666667 262.985 13.4683 208.08455180470114 211.79176280238997 150.67622629038962 179.631;56.9823;6.6423 110.795;16.0812;3.4063 426.677;262.985;13.4683 3 0 3 360918;24614;83619 PF4_32963;ORM1_9400;NFE2L2_9301 81.0852 56.9823 88.97744052977697 43.4275 16.0812 58.68516264516953 234.37676666666667 262.985 208.08455180470114 179.631;56.9823;6.6423 110.795;16.0812;3.4063 426.677;262.985;13.4683 0 0 Exp 4,2(0.67);Poly 2,1(0.34) 1.6565283274134857 4.986849546432495 1.5423688888549805 1.8597915172576904 0.17235111763635125 1.5846891403198242 -19.602252513674486 181.77265251367453 -22.981013123226163 109.83601312322615 -1.0930704506810685 469.84660378401446 UP 1.0 0.0 0.0 GO:0043065 8 positive regulation of apoptotic process 196 210 9 9 7 8 6 6 46 204 2291 0.86839 0.25452 0.43828 2.86 24314;29200;24484;289388;24330;24188 nqo1;inhba;igfbp3;g0s2;egr1;aldh1a1 NQO1_33055;INHBA_33300;IGFBP3_8881;G0S2_32729;EGR1_8533;ALDH1A1_8022 49.900681666666664 34.5075 3.45084 50.029157627387825 52.888870191678514 42.10412648928569 32.165636666666664 17.6453 1.07374 36.66299055471044 32.68945154338549 32.6325749035307 97.5018 84.3351 14.3222 81.3520994369537 108.06888865576103 64.27488109472804 24.1117;130.168;44.9033;3.45084;8.26335;88.5069 16.4151;89.164;18.8755;1.07374;1.51678;65.9487 37.0434;231.33;122.765;14.3222;45.9052;133.645 3 3 3 24314;289388;24188 NQO1_33055;G0S2_32729;ALDH1A1_8022 38.68981333333333 24.1117 44.3624207742379 27.81251333333333 16.4151 33.90598592827723 61.6702 37.0434 63.35883607390527 24.1117;3.45084;88.5069 16.4151;1.07374;65.9487 37.0434;14.3222;133.645 3 29200;24484;24330 INHBA_33300;IGFBP3_8881;EGR1_8533 61.11155 44.9033 62.54771337908766 36.51876 18.8755 46.41090670308866 133.3334 122.765 93.16306898487194 130.168;44.9033;8.26335 89.164;18.8755;1.51678 231.33;122.765;45.9052 0 Exp 4,3(0.5);Hill,1(0.17);Poly 2,2(0.34) 2.7122653727882478 18.234015703201294 1.6357452869415283 5.289852619171143 1.6085483120430741 2.4398833513259888 9.869018240199374 89.93234509313396 2.8291343608502117 61.50213897248313 32.40656317926623 162.59703682073376 CONFLICT 0.5 0.5 0.0 GO:0097237 5 cellular response to toxic substance 71 80 5 5 5 4 4 4 48 76 2419 0.97793 0.078331 0.078331 5.0 286954;24314;83619;24330 ugt2b1;nqo1;nfe2l2;egr1 UGT2B10_33303,UGT2B1_33224;NQO1_33055;NFE2L2_9301;EGR1_8533 16.1284875 16.187525 6.6423 10.055535039832131 15.825356082766268 9.998472922154777 8.169345 7.37275 1.51678 6.95182649841752 7.686974945961757 6.883265553830804 40.0986625 41.4743 13.4683 20.995535504775564 41.78779663300182 20.357224051343234 3.0 25.4966 25.4966;24.1117;6.6423;8.26335 11.3392;16.4151;3.4063;1.51678 63.97775;37.0434;13.4683;45.9052 4 1 3 286954;24314;83619 UGT2B10_33303,UGT2B1_33224;NQO1_33055;NFE2L2_9301 18.7502 24.1117 10.508587859936277 10.386866666666666 11.3392 6.5564795007178445 38.16315 37.0434 25.2733360455738 25.4966;24.1117;6.6423 11.3392;16.4151;3.4063 63.97775;37.0434;13.4683 1 24330 EGR1_8533 8.26335 8.26335 1.51678 1.51678 45.9052 45.9052 8.26335 1.51678 45.9052 0 Exp 4,4(0.8);Hill,1(0.2) 2.5724384322450797 15.007338881492615 1.5423688888549805 5.289852619171143 1.8635472673821425 1.7026138305664062 6.2740631609645146 25.98291183903548 1.3565550315508306 14.98213496844917 19.52303770531994 60.67428729468007 UP 0.75 0.25 0.0 GO:0050673 4 epithelial cell proliferation 37 39 4 4 3 4 3 3 49 36 2459 0.9925 0.043776 0.043776 7.69 24484;25587;58919 igfbp3;id2;ccnd1 IGFBP3_8881;ID2_8861;CCND1_8224 186.87767999999997 44.9033 2.99674 282.97580660188106 212.07720808663043 281.01611294098507 116.63268133333334 18.8755 0.998544 185.01834382212118 131.17692855112205 185.6913092876893 378.7463333333333 122.765 10.914 543.1254731554517 433.4612692372264 532.7291508356197 0.5 23.950020000000002 44.9033;2.99674;512.733 18.8755;0.998544;330.024 122.765;10.914;1002.56 1 2 1 25587 ID2_8861 2.99674 2.99674 0.998544 0.998544 10.914 10.914 2.99674 0.998544 10.914 2 24484;58919 IGFBP3_8881;CCND1_8224 278.81814999999995 278.81814999999995 330.8055533104682 174.44975 174.44975 220.01521430602247 562.6625 562.6625 622.1090105540184 44.9033;512.733 18.8755;330.024 122.765;1002.56 0 Exp 2,1(0.34);Exp 4,1(0.34);Hill,1(0.34) 1.720257727581024 5.188025116920471 1.555469274520874 1.9777342081069946 0.22077556320697309 1.6548216342926025 -133.33958990686514 507.09494990686505 -92.73528426367864 326.0006469303453 -235.85799740155085 993.3506640682174 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0050793 4 regulation of developmental process 584 616 28 27 14 21 12 12 40 604 1891 0.50095 0.62835 1.0 1.95 246273;360918;338475;83619;25333;24539;29200;24484;25587;24330;25695;58919 trib3;pf4;nrep;nfe2l2;mgp;lpl;inhba;igfbp3;id2;egr1;cebpd;ccnd1 TRIB3_10079;PF4_32963;NREP_9364;NFE2L2_9301;MGP_33209;LPL_32544;INHBA_33300;IGFBP3_8881;ID2_8861;EGR1_8533;CEBPD_8283;CCND1_8224 155.42103666666665 60.0019 2.99674 240.2739699186055 204.7131777549084 286.01498370976435 91.75057199999999 16.40335 0.998544 145.34376191753458 117.92293163405104 172.6536736757198 387.5575333333333 157.552 10.914 631.2014056100928 534.6932114216341 765.9395294571286 16.8949;179.631;112.624;6.6423;75.1005;769.435;130.168;44.9033;2.99674;8.26335;5.66035;512.733 6.46469;110.795;79.4619;3.4063;13.9312;444.211;89.164;18.8755;0.998544;1.51678;2.15795;330.024 58.9909;426.677;192.339;13.4683;346.231;2183.16;231.33;122.765;10.914;45.9052;16.35;1002.56 4 8 4 246273;360918;83619;25587 TRIB3_10079;PF4_32963;NFE2L2_9301;ID2_8861 51.541235 11.7686 85.59563615361611 30.4161335 4.9354949999999995 53.632575621061825 127.51255 36.229600000000005 200.66215178975995 16.8949;179.631;6.6423;2.99674 6.46469;110.795;3.4063;0.998544 58.9909;426.677;13.4683;10.914 8 338475;25333;24539;29200;24484;24330;25695;58919 NREP_9364;MGP_33209;LPL_32544;INHBA_33300;IGFBP3_8881;EGR1_8533;CEBPD_8283;CCND1_8224 207.36093749999998 93.86224999999999 279.8778991104753 122.41779125 49.1687 169.52541353177799 517.580025 211.8345 742.2005024887656 112.624;75.1005;769.435;130.168;44.9033;8.26335;5.66035;512.733 79.4619;13.9312;444.211;89.164;18.8755;1.51678;2.15795;330.024 192.339;346.231;2183.16;231.33;122.765;45.9052;16.35;1002.56 0 Exp 2,2(0.17);Exp 4,4(0.34);Hill,3(0.25);Poly 2,3(0.25) 1.9386670085022375 24.897782683372498 1.5423688888549805 5.289852619171143 1.0362720754791448 1.7581347227096558 19.47324027913507 291.36883305419826 9.514597133240969 173.986546866759 30.4217179203132 744.6933487463535 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0030968 5 endoplasmic reticulum unfolded protein response 19 20 3 3 3 2 2 2 50 18 2477 0.99284 0.061463 0.061463 10.0 83619;58919 nfe2l2;ccnd1 NFE2L2_9301;CCND1_8224 259.68764999999996 259.68764999999996 6.6423 357.8601658654467 337.4179003982874 340.5582397465726 166.71515 166.71515 3.4063 230.95359052555347 216.8802204221846 219.7873799737363 508.01415 508.01415 13.4683 699.3934482853302 659.9283138205715 665.5789728994134 0.0 6.6423 1.0 512.733 6.6423;512.733 3.4063;330.024 13.4683;1002.56 1 1 1 83619 NFE2L2_9301 6.6423 6.6423 3.4063 3.4063 13.4683 13.4683 6.6423 3.4063 13.4683 1 58919 CCND1_8224 512.733 512.733 330.024 330.024 1002.56 1002.56 512.733 330.024 1002.56 0 Exp 2,1(0.5);Exp 4,1(0.5) 1.5489052316364686 3.0978381633758545 1.5423688888549805 1.555469274520874 0.009263371540512377 1.5489190816879272 -236.28123599999992 755.6565359999998 -153.37019600000002 486.800496 -461.29571599999986 1477.3240159999998 CONFLICT 0.5 0.5 0.0 GO:0051098 4 regulation of binding 106 113 6 5 3 3 2 2 50 111 2384 0.59162 0.68061 1.0 1.77 246273;25587 trib3;id2 TRIB3_10079;ID2_8861 9.94582 9.94582 2.99674 9.827483182015628 10.528234282433983 9.792906254020494 3.731617 3.731617 0.998544 3.865148903555722 3.960680523536165 3.8515497985912632 34.95245 34.95245 10.914 33.995502008427536 36.96715361653272 33.87589254145284 16.8949;2.99674 6.46469;0.998544 58.9909;10.914 2 0 2 246273;25587 TRIB3_10079;ID2_8861 9.94582 9.94582 9.827483182015628 3.731617 3.731617 3.865148903555722 34.95245 34.95245 33.995502008427536 16.8949;2.99674 6.46469;0.998544 58.9909;10.914 0 0 Exp 4,1(0.5);Hill,1(0.5) 2.118465336877873 4.246944785118103 1.9777342081069946 2.2692105770111084 0.2061049170077306 2.1234723925590515 -3.674376799999999 23.5660168 -1.6252060799999999 9.08844008 -12.162911999999999 82.067812 UP 1.0 0.0 0.0 GO:0051592 6 response to calcium ion 51 56 3 3 2 3 2 2 50 54 2441 0.89545 0.31782 0.31782 3.57 25333;58919 mgp;ccnd1 MGP_33209;CCND1_8224 293.91675 293.91675 75.1005 309.45290841762176 257.2692951043186 305.0820063973996 171.9776 171.9776 13.9312 223.51136236424315 145.50790994990172 220.35435126909442 674.3955 674.3955 346.231 464.09468658938556 619.4343455513983 457.5395295751545 75.1005;512.733 13.9312;330.024 346.231;1002.56 0 2 0 2 25333;58919 MGP_33209;CCND1_8224 293.91675 293.91675 309.45290841762176 171.9776 171.9776 223.51136236424315 674.3955 674.3955 464.09468658938556 75.1005;512.733 13.9312;330.024 346.231;1002.56 0 Exp 2,1(0.5);Hill,1(0.5) 1.7721094834058728 3.5743918418884277 1.555469274520874 2.0189225673675537 0.3277109661351221 1.7871959209442139 -134.96309999999988 722.7965999999999 -137.793344 481.748544 31.193080000000123 1317.5979199999997 DOWN 0.0 1.0 0.0 GO:0006720 5 isoprenoid metabolic process 36 41 6 6 4 6 4 4 48 37 2458 0.99875 0.0089573 0.0089573 9.76 305291;499353;24296;24188 srd5a3;cyp2c24;cyp1a1;aldh1a1 SRD5A3_9939;CYP2C24_32875;CYP1A1_8415;ALDH1A1_8022 273.139975 135.059 88.5069 309.2391651363107 286.14421936360105 320.1077310683225 177.01615 89.45495 65.9487 191.5658671143427 185.5038765069202 198.11324055210264 628.99775 309.298 133.645 770.8005992150304 655.4191991333593 799.9534040388357 1.5 135.059 169.209;733.935;100.909;88.5069 105.547;463.206;73.3629;65.9487 459.211;1763.75;159.385;133.645 3 1 3 305291;24296;24188 SRD5A3_9939;CYP1A1_8415;ALDH1A1_8022 119.54163333333334 100.909 43.4578934694646 81.61953333333334 73.3629 21.050779943349678 250.74699999999999 159.385 180.99327714586528 169.209;100.909;88.5069 105.547;73.3629;65.9487 459.211;159.385;133.645 1 499353 CYP2C24_32875 733.935 733.935 463.206 463.206 1763.75 1763.75 733.935 463.206 1763.75 0 Linear,1(0.25);Poly 2,3(0.75) 1.9320923040292413 7.942094802856445 1.5321133136749268 2.79919695854187 0.5635785264030709 1.8053922653198242 -29.914406833584565 576.1943568335846 -10.718399772055818 364.7506997720558 -126.38683723072984 1384.3823372307297 UP 0.75 0.25 0.0 GO:0031324 6 negative regulation of cellular metabolic process 513 545 30 28 13 18 9 9 43 536 1959 0.29704 0.81369 0.60802 1.65 24522;246273;299270;24484;25587;297417;24330;25695;58919 zfp354a;trib3;serpina6;igfbp3;id2;gfpt1;egr1;cebpd;ccnd1 ZFP354A_10203;TRIB3_10079;SERPINA6_32325;IGFBP3_8881;ID2_8861;GFPT1_8705;EGR1_8533;CEBPD_8283;CCND1_8224 176.89624111111112 15.8474 2.99674 344.1074903652757 122.51484136897226 243.06757320325113 102.70893711111111 6.46469 0.998544 200.72478836173804 73.49096551038642 150.60912298851034 616.1632777777777 45.9052 6.6682 1396.0945292572344 312.46081130717494 766.1616347875886 3.26713;16.8949;15.8474;44.9033;2.99674;981.5;8.26335;5.66035;512.733 1.71987;6.46469;7.7531;18.8755;0.998544;554.87;1.51678;2.15795;330.024 6.6682;58.9909;40.8362;122.765;10.914;4240.48;45.9052;16.35;1002.56 3 6 3 246273;25587;297417 TRIB3_10079;ID2_8861;GFPT1_8705 333.79721333333333 16.8949 560.9701102596025 187.4444113333333 6.46469 318.2116309837028 1436.7949666666664 58.9909 2428.1814536153183 16.8949;2.99674;981.5 6.46469;0.998544;554.87 58.9909;10.914;4240.48 6 24522;299270;24484;24330;25695;58919 ZFP354A_10203;SERPINA6_32325;IGFBP3_8881;EGR1_8533;CEBPD_8283;CCND1_8224 98.445755 12.055375000000002 203.5309177080041 60.34119999999999 4.955525 132.28438188524584 205.84743333333333 43.3707 392.43992507750613 3.26713;15.8474;44.9033;8.26335;5.66035;512.733 1.71987;7.7531;18.8755;1.51678;2.15795;330.024 6.6682;40.8362;122.765;45.9052;16.35;1002.56 0 Exp 2,1(0.12);Exp 4,5(0.56);Hill,2(0.23);Linear,1(0.12) 2.2896302330540266 24.15648639202118 1.5232417583465576 6.495501518249512 1.859156084587987 1.8130581378936768 -47.92065259420235 401.71313481642454 -28.43125795189107 233.8491321741133 -295.95181467028226 1528.2783702258375 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0033598 5 mammary gland epithelial cell proliferation 6 6 2 2 2 2 2 2 50 4 2491 0.99985 0.00582 0.00582 33.33 25587;58919 id2;ccnd1 ID2_8861;CCND1_8224 257.86487 257.86487 2.99674 360.4379660626691 393.91960606379246 304.7847518637002 165.511272 165.511272 0.998544 232.65613112059606 253.3321218927445 196.7329967144201 506.73699999999997 506.73699999999997 10.914 701.199611136515 771.4192393971258 592.9312936196277 0.0 2.99674 0.0 2.99674 2.99674;512.733 0.998544;330.024 10.914;1002.56 1 1 1 25587 ID2_8861 2.99674 2.99674 0.998544 0.998544 10.914 10.914 2.99674 0.998544 10.914 1 58919 CCND1_8224 512.733 512.733 330.024 330.024 1002.56 1002.56 512.733 330.024 1002.56 0 Exp 2,1(0.5);Hill,1(0.5) 1.7539397919767092 3.5332034826278687 1.555469274520874 1.9777342081069946 0.298586397996033 1.7666017413139343 -241.6766647999999 757.4064047999999 -156.93367487999996 487.95621888 -465.07607999999993 1478.55008 CONFLICT 0.5 0.5 0.0 GO:0006082 4 organic acid metabolic process 306 341 38 35 21 29 17 17 35 324 2171 0.99993 2.4441E-4 2.4441E-4 4.99 286954;266730;501907;24539;24424;297417;25598;25315;499353;29277;24296;290277;25612;64392;24188;24763;296925 ugt2b1;slc17a3;rgd1559459;lpl;gstm2;gfpt1;fabp2;ephx1;cyp2c24;cyp2c11;cyp1a1;cryl1;asns;aldh1l1;aldh1a1;acsm3;aass UGT2B10_33303,UGT2B1_33224;SLC17A3_9840;RGD1559459_9690;LPL_32544;GSTM2_8759;GFPT1_8705;FABP2_32859;EPHX1_8567;CYP2C24_32875;CYP2C11_32593;CYP1A1_8415;CRYL1_8388;ASNS_8091;ALDH1L1_32662;ALDH1A1_8022;ACSM3_7976;AASS_7936 235.87099294117644 100.909 3.28268 304.8977461262322 252.07063695174944 300.55734494505674 139.0377998235294 53.5946 0.808077 183.87673346603887 154.08221601688916 183.30301900380567 716.8215735294117 250.463 13.1174 1106.578830820242 654.5620800798648 876.7131217054813 25.4966;58.7587;42.78;769.435;3.28268;981.5;146.645;24.8784;733.935;129.934;100.909;76.0301;154.987;184.03;88.5069;460.125;28.5735 11.3392;46.6655;20.6065;444.211;0.808077;554.87;95.8536;15.4867;463.206;45.3106;73.3629;23.2788;53.5946;111.154;65.9487;331.8;6.14642 63.97775;78.8953;93.6128;2183.16;13.1174;4240.48;319.535;41.3795;1763.75;355.143;159.385;250.463;462.615;1150.07;133.645;748.659;128.079 13 5 12 286954;266730;501907;24424;297417;25598;25315;24296;290277;25612;64392;24188 UGT2B10_33303,UGT2B1_33224;SLC17A3_9840;RGD1559459_9690;GSTM2_8759;GFPT1_8705;FABP2_32859;EPHX1_8567;CYP1A1_8415;CRYL1_8388;ASNS_8091;ALDH1L1_32662;ALDH1A1_8022 157.31703166666668 82.2685 265.62283753326915 89.41404808333334 50.13005 150.63573527925635 583.9313125 146.515 1192.9984813728552 25.4966;58.7587;42.78;3.28268;981.5;146.645;24.8784;100.909;76.0301;154.987;184.03;88.5069 11.3392;46.6655;20.6065;0.808077;554.87;95.8536;15.4867;73.3629;23.2788;53.5946;111.154;65.9487 63.97775;78.8953;93.6128;13.1174;4240.48;319.535;41.3795;159.385;250.463;462.615;1150.07;133.645 5 24539;499353;29277;24763;296925 LPL_32544;CYP2C24_32875;CYP2C11_32593;ACSM3_7976;AASS_7936 424.4004999999999 460.125 338.9418041242479 258.134804 331.8 218.45903204467447 1035.7581999999998 748.659 896.6670902200549 769.435;733.935;129.934;460.125;28.5735 444.211;463.206;45.3106;331.8;6.14642 2183.16;1763.75;355.143;748.659;128.079 0 Exp 2,1(0.06);Exp 4,6(0.34);Hill,3(0.17);Linear,3(0.17);Poly 2,5(0.28) 1.887830601623149 34.564589500427246 1.5232417583465576 2.79919695854187 0.3880431395108163 1.733633041381836 90.93180470054247 380.81018118181044 51.628349201112556 226.44725044594634 190.78738829488634 1242.8557587639373 UP 0.7058823529411765 0.29411764705882354 0.0 GO:0007568 3 aging 181 193 13 13 8 11 7 7 45 186 2309 0.96075 0.09409 0.11 3.63 24314;83619;24484;25587;24424;116686;24296 nqo1;nfe2l2;igfbp3;id2;gstm2;gsr;cyp1a1 NQO1_33055;NFE2L2_9301;IGFBP3_8881;ID2_8861;GSTM2_8759;GSR_8755;CYP1A1_8415 36.78284571428571 24.1117 2.99674 38.60829559916145 56.49830992069941 37.87988861642804 24.450445857142856 16.4151 0.808077 29.20646030565939 37.67191217701123 30.340465108717563 66.17458571428571 37.0434 10.914 61.93344666792004 101.47172713593186 58.18390423227602 24.1117;6.6423;44.9033;2.99674;3.28268;74.6342;100.909 16.4151;3.4063;18.8755;0.998544;0.808077;57.2867;73.3629 37.0434;13.4683;122.765;10.914;13.1174;106.529;159.385 6 1 6 24314;83619;25587;24424;116686;24296 NQO1_33055;NFE2L2_9301;ID2_8861;GSTM2_8759;GSR_8755;CYP1A1_8415 35.42943666666667 15.376999999999999 42.1109744848678 25.3796035 9.910699999999999 31.880539257216437 56.74285 25.25585 62.0939450775597 24.1117;6.6423;2.99674;3.28268;74.6342;100.909 16.4151;3.4063;0.998544;0.808077;57.2867;73.3629 37.0434;13.4683;10.914;13.1174;106.529;159.385 1 24484 IGFBP3_8881 44.9033 44.9033 18.8755 18.8755 122.765 122.765 44.9033 18.8755 122.765 0 Exp 4,3(0.43);Hill,2(0.29);Poly 2,2(0.29) 2.0528754507480205 15.521691918373108 1.5423688888549805 4.773829460144043 1.1393880535881602 1.9061951637268066 8.18142007843954 65.3842713501319 2.8139972764716674 46.08689443781404 20.293646352574186 112.05552507599724 UP 0.8571428571428571 0.14285714285714285 0.0 GO:0030162 7 regulation of proteolysis 214 230 10 10 5 5 2 2 50 228 2267 0.13745 0.95658 0.3216 0.87 246273;299270 trib3;serpina6 TRIB3_10079;SERPINA6_32325 16.37115 16.37115 15.8474 0.7406943532929424 16.578358013010053 0.680263040072556 7.108895 7.108895 6.46469 0.911043447948555 6.854032111176819 0.8367137980524755 49.91355 49.91355 40.8362 12.837311480407413 53.50476652868125 11.78994884353847 16.8949;15.8474 6.46469;7.7531 58.9909;40.8362 1 1 1 246273 TRIB3_10079 16.8949 16.8949 6.46469 6.46469 58.9909 58.9909 16.8949 6.46469 58.9909 1 299270 SERPINA6_32325 15.8474 15.8474 7.7531 7.7531 40.8362 40.8362 15.8474 7.7531 40.8362 0 Exp 4,2(1) 2.0283517207931165 4.082268714904785 1.8130581378936768 2.2692105770111084 0.32254848295471966 2.0411343574523926 15.3446 17.3977 5.8462532000000005 8.3715368 32.121944 67.705156 CONFLICT 0.5 0.5 0.0 GO:0030855 5 epithelial cell differentiation 87 96 3 3 2 3 2 2 50 94 2401 0.68799 0.59082 1.0 2.08 25587;24296 id2;cyp1a1 ID2_8861;CYP1A1_8415 51.952870000000004 51.952870000000004 2.99674 69.23442300730035 84.48325507063572 51.73928317503174 37.180721999999996 37.180721999999996 0.998544 51.16932684379743 61.223067320887985 38.239132738462054 85.14949999999999 85.14949999999999 10.914 104.9848509095479 134.4775290110999 78.45578390571447 2.99674;100.909 0.998544;73.3629 10.914;159.385 2 0 2 25587;24296 ID2_8861;CYP1A1_8415 51.952870000000004 51.952870000000004 69.23442300730035 37.180721999999996 37.180721999999996 51.16932684379743 85.14949999999999 85.14949999999999 104.9848509095479 2.99674;100.909 0.998544;73.3629 10.914;159.385 0 0 Hill,1(0.5);Poly 2,1(0.5) 1.9416352341855094 3.8839293718338013 1.9061951637268066 1.9777342081069946 0.0505857434008363 1.9419646859169006 -44.00114479999999 147.9068848 -33.73634688 108.09779088 -60.35207999999999 230.65107999999998 UP 1.0 0.0 0.0 GO:1902037 8 negative regulation of hematopoietic stem cell differentiation 1 1 1 1 1 1 1 1 51 0 2495 1.0 0.020416 0.020416 100.0 83619 nfe2l2 NFE2L2_9301 6.6423 6.6423 6.6423 6.6423 3.4063 3.4063 3.4063 3.4062999999999994 13.4683 13.4683 13.4683 13.4683 0.0 6.6423 0.0 6.6423 6.6423 3.4063 13.4683 1 0 1 83619 NFE2L2_9301 6.6423 6.6423 3.4063 3.4063 13.4683 13.4683 6.6423 3.4063 13.4683 0 0 Exp 4,1(1) 1.5423688888549805 1.5423688888549805 1.5423688888549805 1.5423688888549805 0.0 1.5423688888549805 6.6423 6.6423 3.4063 3.4063 13.4683 13.4683 UP 1.0 0.0 0.0 GO:1903788 8 positive regulation of glutathione biosynthetic process 1 1 1 1 1 1 1 1 51 0 2495 1.0 0.020416 0.020416 100.0 83619 nfe2l2 NFE2L2_9301 6.6423 6.6423 6.6423 6.6423 3.4063 3.4063 3.4063 3.4062999999999994 13.4683 13.4683 13.4683 13.4683 0.0 6.6423 0.0 6.6423 6.6423 3.4063 13.4683 1 0 1 83619 NFE2L2_9301 6.6423 6.6423 3.4063 3.4063 13.4683 13.4683 6.6423 3.4063 13.4683 0 0 Exp 4,1(1) 1.5423688888549805 1.5423688888549805 1.5423688888549805 1.5423688888549805 0.0 1.5423688888549805 6.6423 6.6423 3.4063 3.4063 13.4683 13.4683 UP 1.0 0.0 0.0 GO:0097190 5 apoptotic signaling pathway 104 107 7 6 4 5 3 3 49 104 2391 0.82763 0.37457 0.47945 2.8 246273;29200;289388 trib3;inhba;g0s2 TRIB3_10079;INHBA_33300;G0S2_32729 50.17124666666667 16.8949 3.45084 69.60456949961356 66.87708220889871 71.90890875377005 32.234143333333336 6.46469 1.07374 49.37633056982904 43.693238535815716 51.55483254027562 101.5477 58.9909 14.3222 114.5923524275944 131.0017398548438 115.150695963637 16.8949;130.168;3.45084 6.46469;89.164;1.07374 58.9909;231.33;14.3222 2 1 2 246273;289388 TRIB3_10079;G0S2_32729 10.17287 10.17287 9.506385992678815 3.769215 3.769215 3.8119773020376186 36.65655 36.65655 31.585540676787534 16.8949;3.45084 6.46469;1.07374 58.9909;14.3222 1 29200 INHBA_33300 130.168 130.168 89.164 89.164 231.33 231.33 130.168 89.164 231.33 0 Exp 4,2(0.67);Poly 2,1(0.34) 1.9766248538073705 5.985525608062744 1.6357452869415283 2.2692105770111084 0.3252518089254954 2.0805697441101074 -28.593738530695944 128.9362318640293 -23.64043464899669 88.10872131566335 -28.125754021442418 231.2211540214424 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0080134 5 regulation of response to stress 340 358 14 12 5 6 3 3 49 355 2140 0.05205 0.98372 0.10416 0.84 316351;83619;24539 npas2;nfe2l2;lpl NPAS2_9350;NFE2L2_9301;LPL_32544 303.5117666666667 134.458 6.6423 408.5309753390351 389.07924600300197 412.19537130238234 168.11406666666667 56.7249 3.4063 240.58856108207502 216.26127441533916 245.94319660619948 839.0254333333332 320.448 13.4683 1174.1305012792077 1078.8316153440176 1193.5457458199562 134.458;6.6423;769.435 56.7249;3.4063;444.211 320.448;13.4683;2183.16 1 2 1 83619 NFE2L2_9301 6.6423 6.6423 3.4063 3.4063 13.4683 13.4683 6.6423 3.4063 13.4683 2 316351;24539 NPAS2_9350;LPL_32544 451.94649999999996 451.94649999999996 448.9965425974903 250.46795 250.46795 273.9940489255287 1251.8039999999999 1251.8039999999999 1317.1362865975561 134.458;769.435 56.7249;444.211 320.448;2183.16 0 Exp 2,1(0.34);Exp 4,1(0.34);Hill,1(0.34) 1.7012876442746732 5.121456861495972 1.5423688888549805 1.8888624906539917 0.17386587236163298 1.6902254819869995 -158.78455175854623 765.8080850918795 -104.1375195225076 440.3656528558409 -489.6283061821764 2167.679172848843 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0042445 4 hormone metabolic process 53 64 9 9 4 9 4 4 48 60 2435 0.99105 0.039865 0.039865 6.25 299270;499353;24296;24188 serpina6;cyp2c24;cyp1a1;aldh1a1 SERPINA6_32325;CYP2C24_32875;CYP1A1_8415;ALDH1A1_8022 234.799575 94.70795000000001 15.8474 334.86537606409706 303.56908732667887 349.4923530356889 152.567675 69.6558 7.7531 209.15996534079486 197.699137464559 215.78292741427964 524.40405 146.515 40.8362 827.7978399252703 678.2642219054646 880.6432953383745 2.5 417.42199999999997 15.8474;733.935;100.909;88.5069 7.7531;463.206;73.3629;65.9487 40.8362;1763.75;159.385;133.645 2 2 2 24296;24188 CYP1A1_8415;ALDH1A1_8022 94.70795000000001 94.70795000000001 8.769609010953614 69.6558 69.6558 5.24263109707331 146.515 146.515 18.200928547741807 100.909;88.5069 73.3629;65.9487 159.385;133.645 2 299270;499353 SERPINA6_32325;CYP2C24_32875 374.89119999999997 374.89119999999997 507.764611445973 235.47955000000002 235.47955000000002 322.0538341010785 902.2931 902.2931 1218.2840313798831 15.8474;733.935 7.7531;463.206 40.8362;1763.75 0 Exp 4,1(0.25);Linear,1(0.25);Poly 2,2(0.5) 2.0151532606938187 8.223039627075195 1.7045893669128418 2.79919695854187 0.5024251715390365 1.8596266508102417 -93.36849354281512 562.967643542815 -52.40909103397891 357.54444103397896 -286.83783312676485 1335.6459331267647 CONFLICT 0.5 0.5 0.0 GO:0009743 5 response to carbohydrate 119 123 13 11 4 7 2 2 50 121 2374 0.53646 0.72571 1.0 1.63 297417;24330 gfpt1;egr1 GFPT1_8705;EGR1_8533 494.881675 494.881675 8.26335 688.1822349142785 171.3558305100182 514.0591836994059 278.19339 278.19339 1.51678 391.2798142534115 94.2462813479053 292.2786606635064 2143.1926 2143.1926 45.9052 2966.0122852742056 748.8211956284151 2215.555381781089 981.5;8.26335 554.87;1.51678 4240.48;45.9052 1 1 1 297417 GFPT1_8705 981.5 981.5 554.87 554.87 4240.48 4240.48 981.5 554.87 4240.48 1 24330 EGR1_8533 8.26335 8.26335 1.51678 1.51678 45.9052 45.9052 8.26335 1.51678 45.9052 0 Hill,1(0.5);Linear,1(0.5) 2.8386131129515335 6.8130943775177 1.5232417583465576 5.289852619171143 2.6633960817799633 3.40654718875885 -458.89024199999994 1448.653592 -264.0927655999999 820.4795455999999 -1967.4907039999994 6253.875903999999 CONFLICT 0.5 0.5 0.0 GO:0071157 7 negative regulation of cell cycle arrest 7 8 2 2 2 2 2 2 50 6 2489 0.99958 0.010583 0.010583 25.0 363140;58919 rassf1;ccnd1 RASSF1_32475;CCND1_8224 634.6569999999999 634.6569999999999 512.733 172.42657437877747 658.1601507102012 169.19257479389307 383.762 383.762 330.024 75.99700841480515 394.1210130972145 74.57162317734219 971.3734999999999 971.3734999999999 940.187 44.10437126295181 965.3617138904261 43.277158178940084 0.0 512.733 0.0 512.733 756.581;512.733 437.5;330.024 940.187;1002.56 1 1 1 363140 RASSF1_32475 756.581 756.581 437.5 437.5 940.187 940.187 756.581 437.5 940.187 1 58919 CCND1_8224 512.733 512.733 330.024 330.024 1002.56 1002.56 512.733 330.024 1002.56 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.8476394025125402 3.7501583099365234 1.555469274520874 2.1946890354156494 0.45199662759713916 1.8750791549682617 395.68595999999985 873.62804 278.43552 489.08848 910.24796 1032.49904 CONFLICT 0.5 0.5 0.0 GO:0009987 2 cellular process 2111 2325 114 105 60 85 48 48 4 2277 218 0.6774 0.52049 1.0 2.06 24522;286954;308843;246273;305291;170698;266730;501907;363140;360918;24614;338475;24314;83619;25333;307126;59107;24539;29200;24484;494344;25587;24424;300850;116686;297417;289388;246248;25598;25315;24330;499353;29277;24296;29276;290277;25695;58919;54232;117517;25612;64392;24188;26760;24763;114628;140668;296925 zfp354a;ugt2b1;tsku;trib3;srd5a3;slco1a2;slc17a3;rgd1559459;rassf1;pf4;orm1;nrep;nqo1;nfe2l2;mgp;mcm10;ltbp1;lpl;inhba;igfbp3;ier2;id2;gstm2;gsta4;gsr;gfpt1;g0s2;fmo5;fabp2;ephx1;egr1;cyp2c24;cyp2c11;cyp1a1;csrp1;cryl1;cebpd;ccnd1;car3;c7;asns;aldh1l1;aldh1a1;akr7a3;acsm3;abcg5;abcc3;aass ZFP354A_10203;UGT2B10_33303,UGT2B1_33224;TSKU_10094;TRIB3_10079;SRD5A3_9939;SLCO1A2_9886;SLC17A3_9840;RGD1559459_9690;RASSF1_32475;PF4_32963;ORM1_9400;NREP_9364;NQO1_33055;NFE2L2_9301;MGP_33209;MCM10_32579;LTBP1_33264;LPL_32544;INHBA_33300;IGFBP3_8881;IER2_32643;ID2_8861;GSTM2_8759;GSTA4_8757;GSR_8755;GFPT1_8705;G0S2_32729;FMO5_33281;FABP2_32859;EPHX1_8567;EGR1_8533;CYP2C24_32875;CYP2C11_32593;CYP1A1_8415;CSRP1_8396;CRYL1_8388;CEBPD_8283;CCND1_8224;CAR3_8196;C7_8179;ASNS_8091;ALDH1L1_32662;ALDH1A1_8022;AKR7A3_8015;ACSM3_7976;ABCG5_7947;ABCC3_7941;AASS_7936 197.2754260416667 81.261 2.99674 266.45071610553975 226.1079945354487 281.7890886818899 118.56456627083332 45.98805 0.808077 159.40424381390054 135.76923274916058 167.37431244409035 535.6050739583334 165.713 6.6682 984.2433713450649 581.5389443442009 988.3826671061788 3.26713;25.4966;6.12626;16.8949;169.209;440.994;58.7587;42.78;756.581;179.631;56.9823;112.624;24.1117;6.6423;75.1005;213.608;998.777;769.435;130.168;44.9033;543.54;2.99674;3.28268;105.355;74.6342;981.5;3.45084;57.4978;146.645;24.8784;8.26335;733.935;129.934;100.909;373.299;76.0301;5.66035;512.733;55.21;13.8429;154.987;184.03;88.5069;19.8501;460.125;360.968;86.4919;28.5735 1.71987;11.3392;1.46625;6.46469;105.547;299.351;46.6655;20.6065;437.5;110.795;16.0812;79.4619;16.4151;3.4063;13.9312;123.177;507.146;444.211;89.164;18.8755;375.947;0.998544;0.808077;75.6422;57.2867;554.87;1.07374;31.5489;95.8536;15.4867;1.51678;463.206;45.3106;73.3629;263.875;23.2788;2.15795;330.024;24.6611;5.32886;53.5946;111.154;65.9487;12.797;331.8;273.647;40.4498;6.14642 6.6682;63.97775;41.3339;58.9909;459.211;772.521;78.8953;93.6128;940.187;426.677;262.985;192.339;37.0434;13.4683;346.231;668.095;5065.92;2183.16;231.33;122.765;978.946;10.914;13.1174;172.041;106.529;4240.48;14.3222;109.026;319.535;41.3795;45.9052;1763.75;355.143;159.385;603.145;250.463;16.35;1002.56;106.714;41.8963;462.615;1150.07;133.645;32.3544;748.659;528.588;108.02;128.079 27 22 26 286954;246273;305291;266730;501907;363140;360918;24614;24314;83619;25587;24424;300850;116686;297417;289388;246248;25598;25315;24296;290277;25612;64392;24188;26760;140668 UGT2B10_33303,UGT2B1_33224;TRIB3_10079;SRD5A3_9939;SLC17A3_9840;RGD1559459_9690;RASSF1_32475;PF4_32963;ORM1_9400;NQO1_33055;NFE2L2_9301;ID2_8861;GSTM2_8759;GSTA4_8757;GSR_8755;GFPT1_8705;G0S2_32729;FMO5_33281;FABP2_32859;EPHX1_8567;CYP1A1_8415;CRYL1_8388;ASNS_8091;ALDH1L1_32662;ALDH1A1_8022;AKR7A3_8015;ABCC3_7941 132.62050615384618 66.69645 226.37530192901033 76.49902888461537 35.99935 129.70590534902132 375.3440365384615 108.523 836.6933369015155 25.4966;16.8949;169.209;58.7587;42.78;756.581;179.631;56.9823;24.1117;6.6423;2.99674;3.28268;105.355;74.6342;981.5;3.45084;57.4978;146.645;24.8784;100.909;76.0301;154.987;184.03;88.5069;19.8501;86.4919 11.3392;6.46469;105.547;46.6655;20.6065;437.5;110.795;16.0812;16.4151;3.4063;0.998544;0.808077;75.6422;57.2867;554.87;1.07374;31.5489;95.8536;15.4867;73.3629;23.2788;53.5946;111.154;65.9487;12.797;40.4498 63.97775;58.9909;459.211;78.8953;93.6128;940.187;426.677;262.985;37.0434;13.4683;10.914;13.1174;172.041;106.529;4240.48;14.3222;109.026;319.535;41.3795;159.385;250.463;462.615;1150.07;133.645;32.3544;108.02 22 24522;308843;170698;338475;25333;307126;59107;24539;29200;24484;494344;24330;499353;29277;29276;25695;58919;54232;117517;24763;114628;296925 ZFP354A_10203;TSKU_10094;SLCO1A2_9886;NREP_9364;MGP_33209;MCM10_32579;LTBP1_33264;LPL_32544;INHBA_33300;IGFBP3_8881;IER2_32643;EGR1_8533;CYP2C24_32875;CYP2C11_32593;CSRP1_8396;CEBPD_8283;CCND1_8224;CAR3_8196;C7_8179;ACSM3_7976;ABCG5_7947;AASS_7936 273.6857859090909 130.051 294.2732894721764 168.27838318181819 84.31295 179.05659082162583 725.0044818181818 350.687 1124.8744177738722 3.26713;6.12626;440.994;112.624;75.1005;213.608;998.777;769.435;130.168;44.9033;543.54;8.26335;733.935;129.934;373.299;5.66035;512.733;55.21;13.8429;460.125;360.968;28.5735 1.71987;1.46625;299.351;79.4619;13.9312;123.177;507.146;444.211;89.164;18.8755;375.947;1.51678;463.206;45.3106;263.875;2.15795;330.024;24.6611;5.32886;331.8;273.647;6.14642 6.6682;41.3339;772.521;192.339;346.231;668.095;5065.92;2183.16;231.33;122.765;978.946;45.9052;1763.75;355.143;603.145;16.35;1002.56;106.714;41.8963;748.659;528.588;128.079 0 Exp 2,5(0.11);Exp 4,15(0.31);Exp 5,3(0.07);Hill,8(0.17);Linear,5(0.11);Poly 2,13(0.27) 2.067480316103724 108.17187309265137 1.5232417583465576 6.495501518249512 1.0059469802590428 1.8597915172576904 121.89608363370874 272.6547684496246 73.46884556363048 163.66028697803623 257.1610180151862 814.0491299014808 CONFLICT 0.5416666666666666 0.4583333333333333 0.0 GO:0019725 4 cellular homeostasis 217 230 12 12 8 8 5 5 47 225 2270 0.67263 0.51191 0.80692 2.17 24314;83619;24424;116686;117517 nqo1;nfe2l2;gstm2;gsr;c7 NQO1_33055;NFE2L2_9301;GSTM2_8759;GSR_8755;C7_8179 24.502755999999998 13.8429 3.28268 29.138611181020288 37.22419498126004 33.8339055426595 16.6490074 5.32886 0.808077 23.48364795395541 26.949026052769348 27.374823785366374 42.41088 37.0434 13.1174 38.19682203413001 58.090285115116906 44.30304335217722 24.1117;6.6423;3.28268;74.6342;13.8429 16.4151;3.4063;0.808077;57.2867;5.32886 37.0434;13.4683;13.1174;106.529;41.8963 4 1 4 24314;83619;24424;116686 NQO1_33055;NFE2L2_9301;GSTM2_8759;GSR_8755 27.167720000000003 15.376999999999999 32.93525964580008 19.47904425 9.910699999999999 26.11350042573188 42.539525 25.25585 44.104640206776054 24.1117;6.6423;3.28268;74.6342 16.4151;3.4063;0.808077;57.2867 37.0434;13.4683;13.1174;106.529 1 117517 C7_8179 13.8429 13.8429 5.32886 5.32886 41.8963 41.8963 13.8429 5.32886 41.8963 0 Exp 4,2(0.4);Hill,2(0.4);Poly 2,1(0.2) 2.272637015506757 12.44443416595459 1.5423688888549805 4.773829460144043 1.323773420535526 1.9608341455459595 -1.0383628253131327 50.04387482531314 -3.9353176084095054 37.23333240840951 8.92988928763161 75.89187071236839 UP 0.8 0.2 0.0 GO:0055085 4 transmembrane transport 188 198 7 6 5 4 4 4 48 194 2301 0.6204 0.58495 1.0 2.02 170698;266730;114628;140668 slco1a2;slc17a3;abcg5;abcc3 SLCO1A2_9886;SLC17A3_9840;ABCG5_7947;ABCC3_7941 236.80315000000002 223.72995 58.7587 192.70366823321413 216.9162691157926 184.24674778128053 165.028325 160.15625 40.4498 140.67713011368443 151.6848471292931 138.09719188913897 372.006075 318.304 78.8953 336.9137766053639 330.8827085713226 313.366265446939 440.994;58.7587;360.968;86.4919 299.351;46.6655;273.647;40.4498 772.521;78.8953;528.588;108.02 2 2 2 266730;140668 SLC17A3_9840;ABCC3_7941 72.6253 72.6253 19.610333784002766 43.55765 43.55765 4.395163619821223 93.45765 93.45765 20.59427287002388 58.7587;86.4919 46.6655;40.4498 78.8953;108.02 2 170698;114628 SLCO1A2_9886;ABCG5_7947 400.981 400.981 56.586927271234906 286.499 286.499 18.175472703617977 650.5545 650.5545 172.4866784551777 440.994;360.968 299.351;273.647 772.521;528.588 0 Exp 2,1(0.25);Exp 5,1(0.25);Linear,1(0.25);Poly 2,1(0.25) 2.160079224480309 8.988863825798035 1.672735333442688 3.368933916091919 0.7749356998843514 1.9735972881317139 47.953555131450145 425.6527448685499 27.164737488589253 302.89191251141074 41.83057392674323 702.1815760732567 CONFLICT 0.5 0.5 0.0 GO:0009611 4 response to wounding 115 120 8 8 5 6 4 4 48 116 2379 0.90477 0.22755 0.30676 3.33 338475;59107;24330;24296 nrep;ltbp1;egr1;cyp1a1 NREP_9364;LTBP1_33264;EGR1_8533;CYP1A1_8415 305.14333750000003 106.76650000000001 8.26335 464.7726127389847 321.3218353203613 467.2402805338342 165.371895 76.41239999999999 1.51678 230.58203165180666 175.06010784992478 230.3176996748886 1365.8873 175.862 45.9052 2467.4857742060626 1428.2920188633273 2499.5206617537774 112.624;998.777;8.26335;100.909 79.4619;507.146;1.51678;73.3629 192.339;5065.92;45.9052;159.385 1 3 1 24296 CYP1A1_8415 100.909 100.909 73.3629 73.3629 159.385 159.385 100.909 73.3629 159.385 3 338475;59107;24330 NREP_9364;LTBP1_33264;EGR1_8533 373.22145 112.624 544.2541648154449 196.04156 79.4619 272.22846999118 1768.0547333333334 192.339 2856.9734339437623 112.624;998.777;8.26335 79.4619;507.146;1.51678 192.339;5065.92;45.9052 0 Exp 2,1(0.25);Hill,1(0.25);Poly 2,2(0.5) 2.345162872484975 10.664835691452026 1.6427439451217651 5.289852619171143 1.752568104142396 1.8661195635795593 -150.33382298420509 760.6204979842051 -60.598496018770504 391.3422860187705 -1052.2487587219418 3784.023358721942 DOWN 0.25 0.75 0.0 GO:0010043 6 response to zinc ion 25 28 2 2 1 2 1 1 51 27 2468 0.8896 0.44048 0.44048 3.57 300850 gsta4 GSTA4_8757 105.355 105.355 105.355 105.355 75.6422 75.6422 75.6422 75.6422 172.041 172.041 172.041 172.041 105.355 75.6422 172.041 1 0 1 300850 GSTA4_8757 105.355 105.355 75.6422 75.6422 172.041 172.041 105.355 75.6422 172.041 0 0 Poly 2,1(1) 2.0709805488586426 2.0709805488586426 2.0709805488586426 2.0709805488586426 0.0 2.0709805488586426 105.355 105.355 75.6422 75.6422 172.041 172.041 UP 1.0 0.0 0.0 GO:0042221 3 response to chemical 909 981 68 62 36 48 29 29 23 952 1543 0.9964 0.0080484 0.013639 2.96 24522;286954;246273;170698;360918;24614;24314;316351;83619;25333;59107;24539;29200;24484;494344;25587;24424;300850;116686;297417;25315;24330;24296;58919;54232;25612;24188;114628;140668 zfp354a;ugt2b1;trib3;slco1a2;pf4;orm1;nqo1;npas2;nfe2l2;mgp;ltbp1;lpl;inhba;igfbp3;ier2;id2;gstm2;gsta4;gsr;gfpt1;ephx1;egr1;cyp1a1;ccnd1;car3;asns;aldh1a1;abcg5;abcc3 ZFP354A_10203;UGT2B10_33303,UGT2B1_33224;TRIB3_10079;SLCO1A2_9886;PF4_32963;ORM1_9400;NQO1_33055;NPAS2_9350;NFE2L2_9301;MGP_33209;LTBP1_33264;LPL_32544;INHBA_33300;IGFBP3_8881;IER2_32643;ID2_8861;GSTM2_8759;GSTA4_8757;GSR_8755;GFPT1_8705;EPHX1_8567;EGR1_8533;CYP1A1_8415;CCND1_8224;CAR3_8196;ASNS_8091;ALDH1A1_8022;ABCG5_7947;ABCC3_7941 207.27992758620692 86.4919 2.99674 289.07218187126085 219.7188203604238 287.4126773662996 122.06445037931034 53.5946 0.808077 168.38061816628198 128.00294374412348 166.45783179505355 621.4836086206897 159.385 6.6682 1208.9985361201695 648.4914051317752 1199.4882113092058 3.26713;25.4966;16.8949;440.994;179.631;56.9823;24.1117;134.458;6.6423;75.1005;998.777;769.435;130.168;44.9033;543.54;2.99674;3.28268;105.355;74.6342;981.5;24.8784;8.26335;100.909;512.733;55.21;154.987;88.5069;360.968;86.4919 1.71987;11.3392;6.46469;299.351;110.795;16.0812;16.4151;56.7249;3.4063;13.9312;507.146;444.211;89.164;18.8755;375.947;0.998544;0.808077;75.6422;57.2867;554.87;15.4867;1.51678;73.3629;330.024;24.6611;53.5946;65.9487;273.647;40.4498 6.6682;63.97775;58.9909;772.521;426.677;262.985;37.0434;320.448;13.4683;346.231;5065.92;2183.16;231.33;122.765;978.946;10.914;13.1174;172.041;106.529;4240.48;41.3795;45.9052;159.385;1002.56;106.714;462.615;133.645;528.588;108.02 17 13 16 286954;246273;360918;24614;24314;83619;25587;24424;300850;116686;297417;25315;24296;25612;24188;140668 UGT2B10_33303,UGT2B1_33224;TRIB3_10079;PF4_32963;ORM1_9400;NQO1_33055;NFE2L2_9301;ID2_8861;GSTM2_8759;GSTA4_8757;GSR_8755;GFPT1_8705;EPHX1_8567;CYP1A1_8415;ASNS_8091;ALDH1A1_8022;ABCC3_7941 120.83128875 65.80825 235.7457499546628 68.9343569375 28.432450000000003 133.74604365185724 394.454265625 107.27449999999999 1034.8719891400483 25.4966;16.8949;179.631;56.9823;24.1117;6.6423;2.99674;3.28268;105.355;74.6342;981.5;24.8784;100.909;154.987;88.5069;86.4919 11.3392;6.46469;110.795;16.0812;16.4151;3.4063;0.998544;0.808077;75.6422;57.2867;554.87;15.4867;73.3629;53.5946;65.9487;40.4498 63.97775;58.9909;426.677;262.985;37.0434;13.4683;10.914;13.1174;172.041;106.529;4240.48;41.3795;159.385;462.615;133.645;108.02 13 24522;170698;316351;25333;59107;24539;29200;24484;494344;24330;58919;54232;114628 ZFP354A_10203;SLCO1A2_9886;NPAS2_9350;MGP_33209;LTBP1_33264;LPL_32544;INHBA_33300;IGFBP3_8881;IER2_32643;EGR1_8533;CCND1_8224;CAR3_8196;ABCG5_7947 313.6782523076923 134.458 321.37383967290754 187.45533461538463 89.164 188.1454134626415 900.9043384615385 346.231 1385.1264666749323 3.26713;440.994;134.458;75.1005;998.777;769.435;130.168;44.9033;543.54;8.26335;512.733;55.21;360.968 1.71987;299.351;56.7249;13.9312;507.146;444.211;89.164;18.8755;375.947;1.51678;330.024;24.6611;273.647 6.6682;772.521;320.448;346.231;5065.92;2183.16;231.33;122.765;978.946;45.9052;1002.56;106.714;528.588 0 Exp 2,4(0.14);Exp 4,10(0.34);Exp 5,2(0.07);Hill,5(0.17);Linear,3(0.1);Poly 2,6(0.2) 2.145731169969372 70.0379627943039 1.5232417583465576 6.495501518249512 1.1925246968540533 1.8975288271903992 102.06838870868935 312.49146646372446 60.780158546926735 183.34874221169397 181.45304026071426 1061.5141769806648 CONFLICT 0.5517241379310345 0.4482758620689655 0.0 GO:0010941 5 regulation of cell death 479 511 21 21 13 15 10 10 42 501 1994 0.52289 0.61604 1.0 1.96 360918;24314;316351;83619;29200;24484;289388;24330;25612;24188 pf4;nqo1;npas2;nfe2l2;inhba;igfbp3;g0s2;egr1;asns;aldh1a1 PF4_32963;NQO1_33055;NPAS2_9350;NFE2L2_9301;INHBA_33300;IGFBP3_8881;G0S2_32729;EGR1_8533;ASNS_8091;ALDH1A1_8022 77.512239 66.7051 3.45084 68.1378664055269 74.03240105230573 57.43994888396395 41.751462000000004 36.23505 1.07374 39.26268799536379 38.02476697700016 31.450874888599056 180.82191 128.205 13.4683 170.65202132339658 170.62519509046294 141.17811930802293 179.631;24.1117;134.458;6.6423;130.168;44.9033;3.45084;8.26335;154.987;88.5069 110.795;16.4151;56.7249;3.4063;89.164;18.8755;1.07374;1.51678;53.5946;65.9487 426.677;37.0434;320.448;13.4683;231.33;122.765;14.3222;45.9052;462.615;133.645 6 4 6 360918;24314;83619;289388;25612;24188 PF4_32963;NQO1_33055;NFE2L2_9301;G0S2_32729;ASNS_8091;ALDH1A1_8022 76.22162333333334 56.3093 77.33139727055801 41.872240000000005 35.00485 43.03405306366575 181.29515 85.3442 209.0349406674181 179.631;24.1117;6.6423;3.45084;154.987;88.5069 110.795;16.4151;3.4063;1.07374;53.5946;65.9487 426.677;37.0434;13.4683;14.3222;462.615;133.645 4 316351;29200;24484;24330 NPAS2_9350;INHBA_33300;IGFBP3_8881;EGR1_8533 79.4481625 87.53565 62.873442177141 41.570295 37.8002 39.21802558467343 180.11205 177.0475 120.57863270528763 134.458;130.168;44.9033;8.26335 56.7249;89.164;18.8755;1.51678 320.448;231.33;122.765;45.9052 0 Exp 4,5(0.5);Hill,2(0.2);Poly 2,3(0.3) 2.3738249579153843 26.159191489219666 1.5423688888549805 5.289852619171143 1.3443015161760714 1.9847161173820496 35.27995186183588 119.7445261381641 17.416195859323576 66.08672814067643 75.05069136006325 286.59312863993677 UP 0.6 0.4 0.0 GO:0046700 5 heterocycle catabolic process 52 63 8 8 6 5 4 4 48 59 2436 0.99163 0.037932 0.037932 6.35 83619;24296;64392;26760 nfe2l2;cyp1a1;aldh1l1;akr7a3 NFE2L2_9301;CYP1A1_8415;ALDH1L1_32662;AKR7A3_8015 77.85785 60.37955 6.6423 82.13897689041015 74.21416507849831 66.3974045579321 50.180049999999994 43.07995 3.4063 51.12254306758093 50.53823581342435 43.467378266011025 338.81942499999997 95.8697 13.4683 544.7012558580245 222.38023655517634 404.9772014196499 2.5 142.4695 6.6423;100.909;184.03;19.8501 3.4063;73.3629;111.154;12.797 13.4683;159.385;1150.07;32.3544 4 0 4 83619;24296;64392;26760 NFE2L2_9301;CYP1A1_8415;ALDH1L1_32662;AKR7A3_8015 77.85785 60.37955 82.13897689041015 50.180049999999994 43.07995 51.12254306758093 338.81942499999997 95.8697 544.7012558580245 6.6423;100.909;184.03;19.8501 3.4063;73.3629;111.154;12.797 13.4683;159.385;1150.07;32.3544 0 0 Exp 4,2(0.5);Poly 2,2(0.5) 2.149378865772392 9.331359267234802 1.5423688888549805 4.1214375495910645 1.201740910432679 1.8337764143943787 -2.63834735260194 158.35404735260192 0.07995779377069567 100.2801422062293 -194.98780574086413 872.626655740864 UP 1.0 0.0 0.0 GO:0051347 6 positive regulation of transferase activity 183 195 4 4 4 3 3 3 49 192 2303 0.42756 0.77367 0.79458 1.54 246273;24330;58919 trib3;egr1;ccnd1 TRIB3_10079;EGR1_8533;CCND1_8224 179.2970833333333 16.8949 8.26335 288.79622367052485 247.07843426636083 306.72053125859026 112.66849 6.46469 1.51678 188.25165005614718 156.91771611067307 199.86266866745603 369.1520333333333 58.9909 45.9052 548.5864089309207 498.22864342341046 582.278528376069 16.8949;8.26335;512.733 6.46469;1.51678;330.024 58.9909;45.9052;1002.56 1 2 1 246273 TRIB3_10079 16.8949 16.8949 6.46469 6.46469 58.9909 58.9909 16.8949 6.46469 58.9909 2 24330;58919 EGR1_8533;CCND1_8224 260.49817499999995 260.49817499999995 356.71391041780424 165.77039 165.77039 232.28968293074104 524.2325999999999 524.2325999999999 676.4570963346604 8.26335;512.733 1.51678;330.024 45.9052;1002.56 0 Exp 2,1(0.34);Exp 4,1(0.34);Hill,1(0.34) 2.652934959570558 9.114532470703125 1.555469274520874 5.289852619171143 1.9823943418059942 2.2692105770111084 -147.50660852183148 506.1007751884981 -100.35830603720329 325.6952860372033 -251.63192797193966 989.9359946386064 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0071375 6 cellular response to peptide hormone stimulus 102 109 15 14 10 9 6 6 46 103 2392 0.99411 0.021909 0.021909 5.5 286954;246273;24614;83619;297417;24330 ugt2b1;trib3;orm1;nfe2l2;gfpt1;egr1 UGT2B10_33303,UGT2B1_33224;TRIB3_10079;ORM1_9400;NFE2L2_9301;GFPT1_8705;EGR1_8533 182.62990833333333 21.19575 6.6423 391.79460163874694 68.30176195122912 205.25881039891942 98.94636166666668 8.901945 1.51678 223.41947101616262 31.263937893429535 117.10815791381131 780.9678583333333 61.484325 13.4683 1697.1286767594422 292.0973380734125 889.1188231169264 4.5 519.24115 25.4966;16.8949;56.9823;6.6423;981.5;8.26335 11.3392;6.46469;16.0812;3.4063;554.87;1.51678 63.97775;58.9909;262.985;13.4683;4240.48;45.9052 6 1 5 286954;246273;24614;83619;297417 UGT2B10_33303,UGT2B1_33224;TRIB3_10079;ORM1_9400;NFE2L2_9301;GFPT1_8705 217.50322 25.4966 427.5016413326117 118.432278 11.3392 244.0237038103162 927.9803899999999 63.97775 1854.241636989702 25.4966;16.8949;56.9823;6.6423;981.5 11.3392;6.46469;16.0812;3.4063;554.87 63.97775;58.9909;262.985;13.4683;4240.48 1 24330 EGR1_8533 8.26335 8.26335 1.51678 1.51678 45.9052 45.9052 8.26335 1.51678 45.9052 0 Exp 4,5(0.72);Hill,1(0.15);Linear,1(0.15) 2.0027885930196274 15.610650897026062 1.5232417583465576 5.289852619171143 1.3731623310628607 1.6986740827560425 -130.87106527736444 496.1308819440311 -79.82644784676378 277.7191711800971 -577.0179083957779 2138.9536250624446 UP 0.8333333333333334 0.16666666666666666 0.0 GO:0002684 5 positive regulation of immune system process 239 264 10 9 4 6 4 4 48 260 2235 0.36043 0.80377 0.65048 1.52 360918;29200;25587;117517 pf4;inhba;id2;c7 PF4_32963;INHBA_33300;ID2_8861;C7_8179 81.65966 72.00545 2.99674 87.06015244411034 72.72264092341253 79.33479251694875 51.571601 47.246430000000004 0.998544 56.617502126717945 46.88891407174018 53.27606988316492 177.704325 136.61315000000002 10.914 192.462929836603 148.6254408870577 162.0162565992981 179.631;130.168;2.99674;13.8429 110.795;89.164;0.998544;5.32886 426.677;231.33;10.914;41.8963 2 2 2 360918;25587 PF4_32963;ID2_8861 91.31387 91.31387 124.89928303586774 55.896772 55.896772 77.6378185878504 218.7955 218.7955 293.9888366664626 179.631;2.99674 110.795;0.998544 426.677;10.914 2 29200;117517 INHBA_33300;C7_8179 72.00545 72.00545 82.25426703220327 47.246430000000004 47.246430000000004 59.28039599572358 136.61315000000002 136.61315000000002 133.94985385525808 130.168;13.8429 89.164;5.32886 231.33;41.8963 0 Hill,2(0.5);Poly 2,2(0.5) 1.9617182340928874 7.934764266014099 1.6357452869415283 2.4614932537078857 0.3486869551510609 1.9187628626823425 -3.659289395228143 166.97860939522812 -3.913551084183581 107.05675308418358 -10.909346239870928 366.31799623987104 CONFLICT 0.5 0.5 0.0 GO:0043603 5 cellular amide metabolic process 114 134 13 11 7 11 7 7 45 127 2368 0.99498 0.017524 0.017524 5.22 24424;300850;116686;25612;64392;24763;296925 gstm2;gsta4;gsr;asns;aldh1l1;acsm3;aass GSTM2_8759;GSTA4_8757;GSR_8755;ASNS_8091;ALDH1L1_32662;ACSM3_7976;AASS_7936 144.42676857142857 105.355 3.28268 153.34413751372946 145.02057462795585 160.99422073935887 90.91885671428572 57.2867 0.808077 112.9137600165975 93.33285834068691 119.54050104147846 397.30148571428566 172.041 13.1174 418.279706555376 359.9717539454754 381.77157377058666 5.5 322.0775 3.28268;105.355;74.6342;154.987;184.03;460.125;28.5735 0.808077;75.6422;57.2867;53.5946;111.154;331.8;6.14642 13.1174;172.041;106.529;462.615;1150.07;748.659;128.079 5 2 5 24424;300850;116686;25612;64392 GSTM2_8759;GSTA4_8757;GSR_8755;ASNS_8091;ALDH1L1_32662 104.457776 105.355 70.73116720599829 59.69711540000001 57.2867 40.040686607260305 380.87448 172.041 461.64526295993977 3.28268;105.355;74.6342;154.987;184.03 0.808077;75.6422;57.2867;53.5946;111.154 13.1174;172.041;106.529;462.615;1150.07 2 24763;296925 ACSM3_7976;AASS_7936 244.34925 244.34925 305.15299208122633 168.97321 168.97321 230.27185473567587 438.369 438.369 438.8163262687475 460.125;28.5735 331.8;6.14642 748.659;128.079 0 Exp 4,1(0.15);Hill,2(0.29);Linear,1(0.15);Poly 2,3(0.43) 1.8840134388571197 13.371358752250671 1.6175053119659424 2.634152889251709 0.36192493840549844 1.7613576650619507 30.827841767543347 258.0256953753138 7.271172705965014 174.56654072260642 87.43554275131822 707.1674286772532 UP 0.7142857142857143 0.2857142857142857 0.0 GO:0055114 3 oxidation-reduction process 260 296 33 32 14 29 12 12 40 284 2211 0.9949 0.013606 0.015119 4.05 305291;24314;116686;246248;499353;29277;24296;290277;64392;24188;26760;296925 srd5a3;nqo1;gsr;fmo5;cyp2c24;cyp2c11;cyp1a1;cryl1;aldh1l1;aldh1a1;akr7a3;aass SRD5A3_9939;NQO1_33055;GSR_8755;FMO5_33281;CYP2C24_32875;CYP2C11_32593;CYP1A1_8415;CRYL1_8388;ALDH1L1_32662;ALDH1A1_8022;AKR7A3_8015;AASS_7936 140.601775 82.2685 19.8501 194.30075692606096 170.99721797661525 237.9142781974145 84.33351 51.29865 6.14642 124.23726708775841 108.11425299413787 150.5582023544489 390.3915666666667 146.515 32.3544 529.9797665551589 423.1461727889639 603.5669251663651 169.209;24.1117;74.6342;57.4978;733.935;129.934;100.909;76.0301;184.03;88.5069;19.8501;28.5735 105.547;16.4151;57.2867;31.5489;463.206;45.3106;73.3629;23.2788;111.154;65.9487;12.797;6.14642 459.211;37.0434;106.529;109.026;1763.75;355.143;159.385;250.463;1150.07;133.645;32.3544;128.079 9 3 9 305291;24314;116686;246248;24296;290277;64392;24188;26760 SRD5A3_9939;NQO1_33055;GSR_8755;FMO5_33281;CYP1A1_8415;CRYL1_8388;ALDH1L1_32662;ALDH1A1_8022;AKR7A3_8015 88.30875555555556 76.0301 56.966146643272054 55.2599 57.2867 37.07431465239782 270.8585333333333 133.645 354.419778921225 169.209;24.1117;74.6342;57.4978;100.909;76.0301;184.03;88.5069;19.8501 105.547;16.4151;57.2867;31.5489;73.3629;23.2788;111.154;65.9487;12.797 459.211;37.0434;106.529;109.026;159.385;250.463;1150.07;133.645;32.3544 3 499353;29277;296925 CYP2C24_32875;CYP2C11_32593;AASS_7936 297.4808333333333 129.934 381.3629077933292 171.55434 45.3106 253.33569889444087 748.9906666666666 355.143 886.1105424631475 733.935;129.934;28.5735 463.206;45.3106;6.14642 1763.75;355.143;128.079 0 Exp 4,3(0.25);Exp 5,1(0.09);Hill,2(0.17);Linear,1(0.09);Poly 2,5(0.42) 2.1202267623368836 27.454650282859802 1.5321133136749268 4.773829460144043 1.0702153966512873 1.8337764143943787 30.665772571290844 250.53777742870915 14.039658795429247 154.62736120457072 90.5272849987042 690.2558483346291 UP 0.75 0.25 0.0 GO:0010041 7 response to iron(III) ion 5 6 3 3 2 3 2 2 50 4 2491 0.99985 0.00582 0.00582 33.33 116686;24296 gsr;cyp1a1 GSR_8755;CYP1A1_8415 87.7716 87.7716 74.6342 18.57908925432025 90.52042980023217 18.167840459964086 65.3248 65.3248 57.2867 11.367590035711236 67.00666770725151 11.115968030298085 132.957 132.957 106.529 37.374836026396125 138.48671470462457 36.547542715905266 0.0 74.6342 0.0 74.6342 74.6342;100.909 57.2867;73.3629 106.529;159.385 2 0 2 116686;24296 GSR_8755;CYP1A1_8415 87.7716 87.7716 18.57908925432025 65.3248 65.3248 11.367590035711236 132.957 132.957 37.374836026396125 74.6342;100.909 57.2867;73.3629 106.529;159.385 0 0 Poly 2,2(1) 1.9333216403666758 3.867029309272766 1.9061951637268066 1.9608341455459595 0.03863559456145145 1.933514654636383 62.02229600000001 113.520904 49.57012400000001 81.07947599999999 81.15812 184.75588 UP 1.0 0.0 0.0 GO:0044283 4 small molecule biosynthetic process 144 161 29 25 14 22 11 11 41 150 2345 0.99994 2.8627E-4 2.8627E-4 6.83 305291;24539;24424;25315;29277;24296;25612;64392;24188;24763;296925 srd5a3;lpl;gstm2;ephx1;cyp2c11;cyp1a1;asns;aldh1l1;aldh1a1;acsm3;aass SRD5A3_9939;LPL_32544;GSTM2_8759;EPHX1_8567;CYP2C11_32593;CYP1A1_8415;ASNS_8091;ALDH1L1_32662;ALDH1A1_8022;ACSM3_7976;AASS_7936 192.1700436363636 129.934 3.28268 228.12002254913563 244.82789879720806 273.61281983010286 113.942727 65.9487 0.808077 142.48953826214841 148.39884332656104 163.7177904426633 530.4058090909091 355.143 13.1174 645.5441424239559 645.5218422788153 780.6758114644934 7.5 176.61950000000002 169.209;769.435;3.28268;24.8784;129.934;100.909;154.987;184.03;88.5069;460.125;28.5735 105.547;444.211;0.808077;15.4867;45.3106;73.3629;53.5946;111.154;65.9487;331.8;6.14642 459.211;2183.16;13.1174;41.3795;355.143;159.385;462.615;1150.07;133.645;748.659;128.079 7 4 7 305291;24424;25315;24296;25612;64392;24188 SRD5A3_9939;GSTM2_8759;EPHX1_8567;CYP1A1_8415;ASNS_8091;ALDH1L1_32662;ALDH1A1_8022 103.68614 100.909 70.60429136680858 60.84313957142857 65.9487 41.68610007590374 345.6318428571429 159.385 399.2634225506675 169.209;3.28268;24.8784;100.909;154.987;184.03;88.5069 105.547;0.808077;15.4867;73.3629;53.5946;111.154;65.9487 459.211;13.1174;41.3795;159.385;462.615;1150.07;133.645 4 24539;29277;24763;296925 LPL_32544;CYP2C11_32593;ACSM3_7976;AASS_7936 347.01687499999997 295.0295 336.53215694253623 206.867005 188.55530000000002 214.7321202812909 853.7602499999999 551.901 922.6018293664118 769.435;129.934;460.125;28.5735 444.211;45.3106;331.8;6.14642 2183.16;355.143;748.659;128.079 0 Exp 2,1(0.1);Exp 4,3(0.28);Hill,2(0.19);Linear,1(0.1);Poly 2,4(0.37) 1.9096203837065941 21.53320050239563 1.5321133136749268 2.79919695854187 0.48186070616437904 1.7059084177017212 57.35972517752032 326.9803620952069 29.73679095141729 198.1486630485827 148.91359965247824 911.8980185293399 UP 0.6363636363636364 0.36363636363636365 0.0 GO:0071396 6 cellular response to lipid 195 209 19 17 10 14 9 9 43 200 2295 0.99177 0.023255 0.03437 4.31 286954;360918;24614;59107;24539;29200;24484;25315;24330 ugt2b1;pf4;orm1;ltbp1;lpl;inhba;igfbp3;ephx1;egr1 UGT2B10_33303,UGT2B1_33224;PF4_32963;ORM1_9400;LTBP1_33264;LPL_32544;INHBA_33300;IGFBP3_8881;EPHX1_8567;EGR1_8533 248.7261055555556 56.9823 8.26335 368.8860295353807 319.8346325425332 416.03949119452614 134.95726444444443 18.8755 1.51678 197.42424660165196 170.3925278733915 225.5879743601859 938.2332722222222 231.33 41.3795 1689.4862334315567 1243.8564929024178 1868.8611439999975 25.4966;179.631;56.9823;998.777;769.435;130.168;44.9033;24.8784;8.26335 11.3392;110.795;16.0812;507.146;444.211;89.164;18.8755;15.4867;1.51678 63.97775;426.677;262.985;5065.92;2183.16;231.33;122.765;41.3795;45.9052 5 5 4 286954;360918;24614;25315 UGT2B10_33303,UGT2B1_33224;PF4_32963;ORM1_9400;EPHX1_8567 71.747075 41.239450000000005 73.46817675744036 38.425525 15.78395 48.29240266635288 198.7548125 163.481375 181.66442148613092 25.4966;179.631;56.9823;24.8784 11.3392;110.795;16.0812;15.4867 63.97775;426.677;262.985;41.3795 5 59107;24539;29200;24484;24330 LTBP1_33264;LPL_32544;INHBA_33300;IGFBP3_8881;EGR1_8533 390.30933 130.168 460.13779106286955 212.182656 89.164 243.78365630141553 1529.8160400000002 231.33 2167.8756625038272 998.777;769.435;130.168;44.9033;8.26335 507.146;444.211;89.164;18.8755;1.51678 5065.92;2183.16;231.33;122.765;45.9052 0 Exp 2,2(0.2);Exp 4,5(0.5);Hill,1(0.1);Poly 2,2(0.2) 1.9729550123200148 21.396170735359192 1.5846891403198242 5.289852619171143 1.1489505312139707 1.694449782371521 7.720566259106818 489.7316448520043 5.973423331365183 263.94110555752366 -165.56440028639486 2042.0309447308393 CONFLICT 0.4444444444444444 0.5555555555555556 0.0 GO:0046165 5 alcohol biosynthetic process 38 41 7 7 2 7 2 2 50 39 2456 0.95036 0.20341 0.20341 4.88 305291;25315 srd5a3;ephx1 SRD5A3_9939;EPHX1_8567 97.0437 97.0437 24.8784 102.05714599272312 138.6651721480351 83.3724604449256 60.51685 60.51685 15.4867 63.68224884569483 86.48807348340328 52.02326325400247 250.29525 250.29525 41.3795 295.4514870433469 370.7878007121964 241.36004566179253 169.209;24.8784 105.547;15.4867 459.211;41.3795 2 0 2 305291;25315 SRD5A3_9939;EPHX1_8567 97.0437 97.0437 102.05714599272312 60.51685 60.51685 63.68224884569483 250.29525 250.29525 295.4514870433469 169.209;24.8784 105.547;15.4867 459.211;41.3795 0 0 Exp 4,1(0.5);Poly 2,1(0.5) 2.0100256285371607 4.169126510620117 1.5321133136749268 2.6370131969451904 0.7812821999926283 2.0845632553100586 -44.40028799999999 238.487688 -27.742243999999992 148.77594399999998 -159.17961999999994 659.7701199999999 UP 1.0 0.0 0.0 GO:0009719 3 response to endogenous stimulus 481 515 42 38 24 30 20 20 32 495 2000 0.99938 0.0017 0.0024195 3.88 286954;246273;170698;24614;24314;83619;25333;59107;29200;24484;494344;25587;24424;297417;25315;24330;58919;25612;24188;140668 ugt2b1;trib3;slco1a2;orm1;nqo1;nfe2l2;mgp;ltbp1;inhba;igfbp3;ier2;id2;gstm2;gfpt1;ephx1;egr1;ccnd1;asns;aldh1a1;abcc3 UGT2B10_33303,UGT2B1_33224;TRIB3_10079;SLCO1A2_9886;ORM1_9400;NQO1_33055;NFE2L2_9301;MGP_33209;LTBP1_33264;INHBA_33300;IGFBP3_8881;IER2_32643;ID2_8861;GSTM2_8759;GFPT1_8705;EPHX1_8567;EGR1_8533;CCND1_8224;ASNS_8091;ALDH1A1_8022;ABCC3_7941 211.3625285 66.0414 2.99674 315.36714616363594 208.3046922869117 301.8880793001909 121.09091955 17.6453 0.808077 182.09204969998308 115.57188422634871 171.53815017578114 700.6407225 128.205 10.914 1393.6306115958594 702.599977360079 1396.9702904500691 25.4966;16.8949;440.994;56.9823;24.1117;6.6423;75.1005;998.777;130.168;44.9033;543.54;2.99674;3.28268;981.5;24.8784;8.26335;512.733;154.987;88.5069;86.4919 11.3392;6.46469;299.351;16.0812;16.4151;3.4063;13.9312;507.146;89.164;18.8755;375.947;0.998544;0.808077;554.87;15.4867;1.51678;330.024;53.5946;65.9487;40.4498 63.97775;58.9909;772.521;262.985;37.0434;13.4683;346.231;5065.92;231.33;122.765;978.946;10.914;13.1174;4240.48;41.3795;45.9052;1002.56;462.615;133.645;108.02 13 8 12 286954;246273;24614;24314;83619;25587;24424;297417;25315;25612;24188;140668 UGT2B10_33303,UGT2B1_33224;TRIB3_10079;ORM1_9400;NQO1_33055;NFE2L2_9301;ID2_8861;GSTM2_8759;GFPT1_8705;EPHX1_8567;ASNS_8091;ALDH1A1_8022;ABCC3_7941 122.73095166666667 25.1875 274.254292174975 65.48857591666668 15.78395 155.57079461360635 453.88635416666665 61.484325 1199.748077619018 25.4966;16.8949;56.9823;24.1117;6.6423;2.99674;3.28268;981.5;24.8784;154.987;88.5069;86.4919 11.3392;6.46469;16.0812;16.4151;3.4063;0.998544;0.808077;554.87;15.4867;53.5946;65.9487;40.4498 63.97775;58.9909;262.985;37.0434;13.4683;10.914;13.1174;4240.48;41.3795;462.615;133.645;108.02 8 170698;25333;59107;29200;24484;494344;24330;58919 SLCO1A2_9886;MGP_33209;LTBP1_33264;INHBA_33300;IGFBP3_8881;IER2_32643;EGR1_8533;CCND1_8224 344.30989375 285.581 343.6435079325401 204.49443499999998 194.2575 196.76641869612982 1070.772275 559.376 1657.9650975975094 440.994;75.1005;998.777;130.168;44.9033;543.54;8.26335;512.733 299.351;13.9312;507.146;89.164;18.8755;375.947;1.51678;330.024 772.521;346.231;5065.92;231.33;122.765;978.946;45.9052;1002.56 0 Exp 2,3(0.15);Exp 4,9(0.43);Exp 5,1(0.05);Hill,4(0.2);Linear,2(0.1);Poly 2,2(0.1) 2.084569607085575 47.258885622024536 1.5232417583465576 5.289852619171143 1.056820591195107 1.7026138305664062 73.14678266836759 349.5782743316323 41.285560096879266 200.89627900312072 89.85517702162213 1311.4262679783774 UP 0.6 0.4 0.0 GO:0038183 5 bile acid signaling pathway 14 14 3 3 3 3 3 3 49 11 2484 0.99987 0.0024934 0.0024934 21.43 170698;64392;114628 slco1a2;aldh1l1;abcg5 SLCO1A2_9886;ALDH1L1_32662;ABCG5_7947 328.66400000000004 360.968 184.03 131.4925307232315 352.80779570977074 105.66687272651062 228.05066666666667 273.647 111.154 102.04801277993275 252.055119023603 81.87834613387747 817.0596666666667 772.521 528.588 313.12575541199567 712.1325505345976 282.5212654208157 0.0 184.03 0.5 272.499 440.994;184.03;360.968 299.351;111.154;273.647 772.521;1150.07;528.588 1 2 1 64392 ALDH1L1_32662 184.03 184.03 111.154 111.154 1150.07 1150.07 184.03 111.154 1150.07 2 170698;114628 SLCO1A2_9886;ABCG5_7947 400.981 400.981 56.586927271234906 286.499 286.499 18.175472703617977 650.5545 650.5545 172.4866784551777 440.994;360.968 299.351;273.647 772.521;528.588 0 Exp 2,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 1.8508176054441439 5.585963249206543 1.672735333442688 2.1518702507019043 0.25492622009182475 1.7613576650619507 179.86619390141348 477.4618060985865 112.57246927509593 343.52886405823745 462.7245178791175 1171.3948154542159 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0009966 5 regulation of signal transduction 594 626 24 22 15 15 11 11 41 615 1880 0.34688 0.76716 0.62874 1.76 308843;246273;360918;338475;83619;59107;29200;24484;24424;289388;24330 tsku;trib3;pf4;nrep;nfe2l2;ltbp1;inhba;igfbp3;gstm2;g0s2;egr1 TSKU_10094;TRIB3_10079;PF4_32963;NREP_9364;NFE2L2_9301;LTBP1_33264;INHBA_33300;IGFBP3_8881;GSTM2_8759;G0S2_32729;EGR1_8533 137.34214818181817 16.8949 3.28268 292.30694579440404 205.1705040359629 373.5753347737334 74.56165790909091 6.46469 0.808077 149.33154277322902 107.56478669941723 189.5867634577855 566.0153545454546 58.9909 13.1174 1497.8292595633577 928.5125425591256 1933.7174214492447 6.12626;16.8949;179.631;112.624;6.6423;998.777;130.168;44.9033;3.28268;3.45084;8.26335 1.46625;6.46469;110.795;79.4619;3.4063;507.146;89.164;18.8755;0.808077;1.07374;1.51678 41.3339;58.9909;426.677;192.339;13.4683;5065.92;231.33;122.765;13.1174;14.3222;45.9052 5 6 5 246273;360918;83619;24424;289388 TRIB3_10079;PF4_32963;NFE2L2_9301;GSTM2_8759;G0S2_32729 41.980344 6.6423 77.1488688011631 24.509561400000003 3.4063 48.28855979269257 105.31516000000002 14.3222 180.71757017731562 16.8949;179.631;6.6423;3.28268;3.45084 6.46469;110.795;3.4063;0.808077;1.07374 58.9909;426.677;13.4683;13.1174;14.3222 6 308843;338475;59107;29200;24484;24330 TSKU_10094;NREP_9364;LTBP1_33264;INHBA_33300;IGFBP3_8881;EGR1_8533 216.81031833333336 78.76365 386.59156868195976 116.27173833333335 49.1687 195.2984945995028 949.9321833333333 157.552 2017.8559617835783 6.12626;112.624;998.777;130.168;44.9033;8.26335 1.46625;79.4619;507.146;89.164;18.8755;1.51678 41.3339;192.339;5065.92;231.33;122.765;45.9052 0 Exp 2,1(0.1);Exp 4,4(0.37);Hill,3(0.28);Poly 2,3(0.28) 2.024912237003406 23.871949076652527 1.5423688888549805 5.289852619171143 1.0696717379508125 1.826043963432312 -35.40021791972663 310.08451428336303 -13.687644419788143 162.81096023797 -319.14517289231924 1451.1758819832285 CONFLICT 0.45454545454545453 0.5454545454545454 0.0 GO:0070980 6 biphenyl catabolic process 1 2 1 1 1 1 1 1 51 1 2494 0.99959 0.040423 0.040423 50.0 286954 ugt2b1 UGT2B10_33303,UGT2B1_33224 25.4966 25.4966 25.4966 25.4966 11.3392 11.3392 11.3392 11.3392 63.97775 63.97775 63.97775 63.97775 0.0 25.4966 0.0 25.4966 25.4966 11.3392 63.97775 2 0 1 286954 UGT2B10_33303,UGT2B1_33224 25.4966 25.4966 11.3392 11.3392 63.97775 63.97775 25.4966 11.3392 63.97775 0 0 Exp 4,2(1) 1.7006428157979387 3.4012879133224487 1.6986740827560425 1.7026138305664062 0.0027858223928730738 1.7006439566612244 25.4966 25.4966 11.3392 11.3392 63.97775 63.97775 UP 1.0 0.0 0.0 GO:0033554 4 cellular response to stress 394 417 28 27 14 20 11 11 41 406 2089 0.86942 0.22058 0.34389 2.64 246273;363140;338475;24314;83619;307126;25587;116686;24330;58919;25612 trib3;rassf1;nrep;nqo1;nfe2l2;mcm10;id2;gsr;egr1;ccnd1;asns TRIB3_10079;RASSF1_32475;NREP_9364;NQO1_33055;NFE2L2_9301;MCM10_32579;ID2_8861;GSR_8755;EGR1_8533;CCND1_8224;ASNS_8091 171.2796536363636 74.6342 2.99674 245.25456038511507 254.7952409114565 288.3048165017994 100.89505581818183 53.5946 0.998544 147.07522488330594 152.1932489491063 170.38461430028823 321.69516363636365 106.529 10.914 382.9724286235245 444.98000250340965 414.06797939806535 16.8949;756.581;112.624;24.1117;6.6423;213.608;2.99674;74.6342;8.26335;512.733;154.987 6.46469;437.5;79.4619;16.4151;3.4063;123.177;0.998544;57.2867;1.51678;330.024;53.5946 58.9909;940.187;192.339;37.0434;13.4683;668.095;10.914;106.529;45.9052;1002.56;462.615 7 4 7 246273;363140;24314;83619;25587;116686;25612 TRIB3_10079;RASSF1_32475;NQO1_33055;NFE2L2_9301;ID2_8861;GSR_8755;ASNS_8091 148.12112 24.1117 273.6624723182668 82.23799057142857 16.4151 158.3996186801394 232.82108571428574 58.9909 350.00612033458515 16.8949;756.581;24.1117;6.6423;2.99674;74.6342;154.987 6.46469;437.5;16.4151;3.4063;0.998544;57.2867;53.5946 58.9909;940.187;37.0434;13.4683;10.914;106.529;462.615 4 338475;307126;24330;58919 NREP_9364;MCM10_32579;EGR1_8533;CCND1_8224 211.8070875 163.11599999999999 217.42967140456537 133.54492 101.31945 140.31859635243507 477.22479999999996 430.217 439.54712375082914 112.624;213.608;8.26335;512.733 79.4619;123.177;1.51678;330.024 192.339;668.095;45.9052;1002.56 0 Exp 2,1(0.1);Exp 4,4(0.37);Hill,2(0.19);Poly 2,4(0.37) 2.3459047480531523 28.128182291984558 1.5423688888549805 5.289852619171143 1.267512194330302 2.103997230529785 26.343470395896645 316.21583687683056 13.979152153242467 187.81095948312117 95.37292113100233 548.0174061417249 UP 0.6363636363636364 0.36363636363636365 0.0 GO:0045471 5 response to ethanol 109 117 13 13 10 9 7 7 45 110 2385 0.99785 0.0086448 0.0086448 5.98 286954;24314;116686;24330;58919;54232;24188 ugt2b1;nqo1;gsr;egr1;ccnd1;car3;aldh1a1 UGT2B10_33303,UGT2B1_33224;NQO1_33055;GSR_8755;EGR1_8533;CCND1_8224;CAR3_8196;ALDH1A1_8022 112.70796428571428 55.21 8.26335 178.75735215365435 140.64301850925386 200.45532690575072 72.45594000000001 24.6611 1.51678 116.05049070341697 92.40782386384956 129.04294487645433 213.7677642857143 106.529 37.0434 349.6235831323152 265.1257301685502 394.21286511462876 4.5 81.57055 25.4966;24.1117;74.6342;8.26335;512.733;55.21;88.5069 11.3392;16.4151;57.2867;1.51678;330.024;24.6611;65.9487 63.97775;37.0434;106.529;45.9052;1002.56;106.714;133.645 5 3 4 286954;24314;116686;24188 UGT2B10_33303,UGT2B1_33224;NQO1_33055;GSR_8755;ALDH1A1_8022 53.18735 50.065400000000004 33.264641115404615 37.747425 36.8509 27.86609419292856 85.2987875 85.253375 43.09387910419869 25.4966;24.1117;74.6342;88.5069 11.3392;16.4151;57.2867;65.9487 63.97775;37.0434;106.529;133.645 3 24330;58919;54232 EGR1_8533;CCND1_8224;CAR3_8196 192.0687833333333 55.21 278.6936523754906 118.73396000000001 24.6611 183.34809963418436 385.0597333333333 106.714 535.6345414920636 8.26335;512.733;55.21 1.51678;330.024;24.6611 45.9052;1002.56;106.714 0 Exp 2,1(0.13);Exp 4,3(0.38);Exp 5,1(0.13);Hill,1(0.13);Poly 2,2(0.25) 2.5372930587623514 22.53528642654419 1.555469274520874 5.289852619171143 1.4523554500637934 2.3578251004219055 -19.717335384716094 245.13326395614467 -13.515466619911265 158.42734661991125 -45.23701068068405 472.77253925211255 CONFLICT 0.5714285714285714 0.42857142857142855 0.0 GO:0006730 4 one-carbon metabolic process 9 10 2 2 2 2 2 2 50 8 2487 0.99913 0.01657 0.01657 20.0 54232;64392 car3;aldh1l1 CAR3_8196;ALDH1L1_32662 119.62 119.62 55.21 91.08949555245104 138.47056644880175 87.1011394249158 67.90755 67.90755 24.6611 61.15971611448994 80.56428155410312 58.48183622236686 628.3919999999999 628.3919999999999 106.714 737.7641027916715 781.0690036310821 705.4610807780035 0.0 55.21 0.0 55.21 55.21;184.03 24.6611;111.154 106.714;1150.07 1 1 1 64392 ALDH1L1_32662 184.03 184.03 111.154 111.154 1150.07 1150.07 184.03 111.154 1150.07 1 54232 CAR3_8196 55.21 55.21 24.6611 24.6611 106.714 106.714 55.21 24.6611 106.714 0 Exp 5,1(0.5);Poly 2,1(0.5) 2.202774699063569 4.516173720359802 1.7613576650619507 2.7548160552978516 0.7024811645624769 2.258086860179901 -6.623599999999968 245.86359999999996 -16.855491999999984 152.670592 -394.09687999999994 1650.8808800000002 CONFLICT 0.5 0.5 0.0 GO:1904469 7 positive regulation of tumor necrosis factor secretion 9 9 2 2 2 2 2 2 50 7 2488 0.99938 0.01343 0.01343 22.22 24614;24539 orm1;lpl ORM1_9400;LPL_32544 413.20865 413.20865 56.9823 503.78013544466495 408.2806174901185 503.7319265837813 230.14610000000002 230.14610000000002 16.0812 302.7334848080404 227.18472786561262 302.70451495506865 1223.0725 1223.0725 262.985 1357.7687635648786 1209.7906571146243 1357.6388329049944 0.0 56.9823 0.0 56.9823 56.9823;769.435 16.0812;444.211 262.985;2183.16 1 1 1 24614 ORM1_9400 56.9823 56.9823 16.0812 16.0812 262.985 262.985 56.9823 16.0812 262.985 1 24539 LPL_32544 769.435 769.435 444.211 444.211 2183.16 2183.16 769.435 444.211 2183.16 0 Exp 2,1(0.5);Exp 4,1(0.5) 1.6366068452736713 3.2749146223068237 1.5846891403198242 1.6902254819869995 0.07462546285448003 1.6374573111534119 -284.99499599999996 1111.412296 -189.42110399999996 649.7133039999999 -658.6989999999996 3104.843999999999 CONFLICT 0.5 0.5 0.0 GO:0050794 4 regulation of cellular process 1555 1680 71 67 39 51 31 31 21 1649 846 0.20263 0.86872 0.375 1.85 24522;308843;246273;170698;299270;363140;360918;24614;338475;24314;316351;83619;59107;24539;29200;24484;494344;25587;24424;116686;297417;289388;24330;24296;289185;25695;58919;25612;64392;24188;114628 zfp354a;tsku;trib3;slco1a2;serpina6;rassf1;pf4;orm1;nrep;nqo1;npas2;nfe2l2;ltbp1;lpl;inhba;igfbp3;ier2;id2;gstm2;gsr;gfpt1;g0s2;egr1;cyp1a1;creg1;cebpd;ccnd1;asns;aldh1l1;aldh1a1;abcg5 ZFP354A_10203;TSKU_10094;TRIB3_10079;SLCO1A2_9886;SERPINA6_32325;RASSF1_32475;PF4_32963;ORM1_9400;NREP_9364;NQO1_33055;NPAS2_9350;NFE2L2_9301;LTBP1_33264;LPL_32544;INHBA_33300;IGFBP3_8881;IER2_32643;ID2_8861;GSTM2_8759;GSR_8755;GFPT1_8705;G0S2_32729;EGR1_8533;CYP1A1_8415;CREG1_8380;CEBPD_8283;CCND1_8224;ASNS_8091;ALDH1L1_32662;ALDH1A1_8022;ABCG5_7947 219.91054677419356 94.3216 2.99674 299.2333397165918 253.76068554807523 309.78858412044184 131.2313387419355 57.2867 0.808077 173.0594879611086 150.7212553485484 177.37049507768506 636.371635483871 159.385 6.6682 1178.484923211308 674.3159349555026 1172.8625446724714 3.26713;6.12626;16.8949;440.994;15.8474;756.581;179.631;56.9823;112.624;24.1117;134.458;6.6423;998.777;769.435;130.168;44.9033;543.54;2.99674;3.28268;74.6342;981.5;3.45084;8.26335;100.909;94.3216;5.66035;512.733;154.987;184.03;88.5069;360.968 1.71987;1.46625;6.46469;299.351;7.7531;437.5;110.795;16.0812;79.4619;16.4151;56.7249;3.4063;507.146;444.211;89.164;18.8755;375.947;0.998544;0.808077;57.2867;554.87;1.07374;1.51678;73.3629;69.2457;2.15795;330.024;53.5946;111.154;65.9487;273.647 6.6682;41.3339;58.9909;772.521;40.8362;940.187;426.677;262.985;192.339;37.0434;320.448;13.4683;5065.92;2183.16;231.33;122.765;978.946;10.914;13.1174;106.529;4240.48;14.3222;45.9052;159.385;147.421;16.35;1002.56;462.615;1150.07;133.645;528.588 16 15 16 246273;363140;360918;24614;24314;83619;25587;24424;116686;297417;289388;24296;289185;25612;64392;24188 TRIB3_10079;RASSF1_32475;PF4_32963;ORM1_9400;NQO1_33055;NFE2L2_9301;ID2_8861;GSTM2_8759;GSR_8755;GFPT1_8705;G0S2_32729;CYP1A1_8415;CREG1_8380;ASNS_8091;ALDH1L1_32662;ALDH1A1_8022 170.591385 81.57055 282.4844705344719 98.6878281875 55.440650000000005 161.11152049845748 511.1156375 140.53300000000002 1050.5731422384117 16.8949;756.581;179.631;56.9823;24.1117;6.6423;2.99674;3.28268;74.6342;981.5;3.45084;100.909;94.3216;154.987;184.03;88.5069 6.46469;437.5;110.795;16.0812;16.4151;3.4063;0.998544;0.808077;57.2867;554.87;1.07374;73.3629;69.2457;53.5946;111.154;65.9487 58.9909;940.187;426.677;262.985;37.0434;13.4683;10.914;13.1174;106.529;4240.48;14.3222;159.385;147.421;462.615;1150.07;133.645 15 24522;308843;170698;299270;338475;316351;59107;24539;29200;24484;494344;24330;25695;58919;114628 ZFP354A_10203;TSKU_10094;SLCO1A2_9886;SERPINA6_32325;NREP_9364;NPAS2_9350;LTBP1_33264;LPL_32544;INHBA_33300;IGFBP3_8881;IER2_32643;EGR1_8533;CEBPD_8283;CCND1_8224;ABCG5_7947 272.51765266666666 130.168 317.22287311647204 165.94441666666665 79.4619 184.02513661541812 769.9780333333333 231.33 1325.3155267307618 3.26713;6.12626;440.994;15.8474;112.624;134.458;998.777;769.435;130.168;44.9033;543.54;8.26335;5.66035;512.733;360.968 1.71987;1.46625;299.351;7.7531;79.4619;56.7249;507.146;444.211;89.164;18.8755;375.947;1.51678;2.15795;330.024;273.647 6.6682;41.3339;772.521;40.8362;192.339;320.448;5065.92;2183.16;231.33;122.765;978.946;45.9052;16.35;1002.56;528.588 0 Exp 2,4(0.13);Exp 4,10(0.33);Hill,5(0.17);Linear,3(0.1);Poly 2,9(0.3) 2.060913278442417 69.23517298698425 1.5232417583465576 6.495501518249512 1.160229112505965 1.8309566974639893 114.57251383588662 325.2485797125004 70.30983159838183 192.15284588548923 221.51383997183 1051.2294309959111 CONFLICT 0.5161290322580645 0.4838709677419355 0.0 GO:0007166 5 cell surface receptor signaling pathway 368 386 15 14 8 10 5 5 47 381 2114 0.17734 0.91397 0.33014 1.3 360918;29200;289388;24330;58919 pf4;inhba;g0s2;egr1;ccnd1 PF4_32963;INHBA_33300;G0S2_32729;EGR1_8533;CCND1_8224 166.84923799999999 130.168 3.45084 207.962126250205 239.60923983655007 254.07275241057815 106.51470400000001 89.164 1.07374 134.55308821717725 153.6542347104946 164.5464531309637 344.15888 231.33 14.3222 403.35441122374255 478.52896445114595 487.4966704370857 179.631;130.168;3.45084;8.26335;512.733 110.795;89.164;1.07374;1.51678;330.024 426.677;231.33;14.3222;45.9052;1002.56 2 3 2 360918;289388 PF4_32963;G0S2_32729 91.54092 91.54092 124.57818584653091 55.93437 55.93437 77.58464698633229 220.49960000000002 220.49960000000002 291.57887533482256 179.631;3.45084 110.795;1.07374 426.677;14.3222 3 29200;24330;58919 INHBA_33300;EGR1_8533;CCND1_8224 217.05478333333335 130.168 263.2192845923163 140.23492666666667 89.164 170.10416826455526 426.5984 231.33 507.34052925000964 130.168;8.26335;512.733 89.164;1.51678;330.024 231.33;45.9052;1002.56 0 Exp 2,1(0.2);Exp 4,1(0.2);Hill,1(0.2);Poly 2,2(0.4) 2.2046184904582455 12.421428442001343 1.555469274520874 5.289852619171143 1.5816847094237676 1.8597915172576904 -15.437602808013906 349.13607880801385 -11.426277919764644 224.45568591976462 -9.396849948111424 697.7146099481113 DOWN 0.4 0.6 0.0 GO:0014070 5 response to organic cyclic compound 433 471 36 33 19 29 17 17 35 454 2041 0.9961 0.0094904 0.011301 3.61 24522;286954;170698;24614;24314;25333;59107;29200;24484;24424;25315;24330;24296;58919;25612;24188;140668 zfp354a;ugt2b1;slco1a2;orm1;nqo1;mgp;ltbp1;inhba;igfbp3;gstm2;ephx1;egr1;cyp1a1;ccnd1;asns;aldh1a1;abcc3 ZFP354A_10203;UGT2B10_33303,UGT2B1_33224;SLCO1A2_9886;ORM1_9400;NQO1_33055;MGP_33209;LTBP1_33264;INHBA_33300;IGFBP3_8881;GSTM2_8759;EPHX1_8567;EGR1_8533;CYP1A1_8415;CCND1_8224;ASNS_8091;ALDH1A1_8022;ABCC3_7941 163.52075058823527 75.1005 3.26713 259.7676654869121 177.94515894271836 277.2890231572632 91.48321335294118 18.8755 0.808077 145.1487982826454 97.72684881207195 152.81901600134285 522.1216735294119 133.645 6.6682 1203.3064287103707 603.7455001220641 1325.2082211059412 3.26713;25.4966;440.994;56.9823;24.1117;75.1005;998.777;130.168;44.9033;3.28268;24.8784;8.26335;100.909;512.733;154.987;88.5069;86.4919 1.71987;11.3392;299.351;16.0812;16.4151;13.9312;507.146;89.164;18.8755;0.808077;15.4867;1.51678;73.3629;330.024;53.5946;65.9487;40.4498 6.6682;63.97775;772.521;262.985;37.0434;346.231;5065.92;231.33;122.765;13.1174;41.3795;45.9052;159.385;1002.56;462.615;133.645;108.02 10 8 9 286954;24614;24314;24424;25315;24296;25612;24188;140668 UGT2B10_33303,UGT2B1_33224;ORM1_9400;NQO1_33055;GSTM2_8759;EPHX1_8567;CYP1A1_8415;ASNS_8091;ALDH1A1_8022;ABCC3_7941 62.84960888888889 56.9823 48.830575081251204 32.60958633333333 16.4151 26.37843895409149 142.46311666666668 108.02 142.65109173618774 25.4966;56.9823;24.1117;3.28268;24.8784;100.909;154.987;88.5069;86.4919 11.3392;16.0812;16.4151;0.808077;15.4867;73.3629;53.5946;65.9487;40.4498 63.97775;262.985;37.0434;13.1174;41.3795;159.385;462.615;133.645;108.02 8 24522;170698;25333;59107;29200;24484;24330;58919 ZFP354A_10203;SLCO1A2_9886;MGP_33209;LTBP1_33264;INHBA_33300;IGFBP3_8881;EGR1_8533;CCND1_8224 276.775785 102.63425000000001 351.8860831336247 157.71604375 54.01975 194.65535982047123 949.23755 288.7805 1700.7417607185932 3.26713;440.994;75.1005;998.777;130.168;44.9033;8.26335;512.733 1.71987;299.351;13.9312;507.146;89.164;18.8755;1.51678;330.024 6.6682;772.521;346.231;5065.92;231.33;122.765;45.9052;1002.56 0 Exp 2,3(0.17);Exp 4,8(0.45);Exp 5,1(0.06);Hill,3(0.17);Poly 2,3(0.17) 2.3182666094236533 46.7769992351532 1.555469274520874 6.495501518249512 1.4698246102116594 1.806051790714264 40.035040886564616 287.006460289906 22.483854504023284 160.48257220185906 -49.89389299370271 1094.1372400525265 CONFLICT 0.5294117647058824 0.47058823529411764 0.0 GO:0031331 7 positive regulation of cellular catabolic process 107 115 12 11 4 7 2 2 50 113 2382 0.58045 0.69007 1.0 1.74 246273;24484 trib3;igfbp3 TRIB3_10079;IGFBP3_8881 30.8991 30.8991 16.8949 19.8049295701853 39.239219108826056 15.909747382695587 12.670095 12.670095 6.46469 8.77576791101781 16.365687523564695 7.049772636588753 90.87795 90.87795 58.9909 45.09509857406901 109.86809545844045 36.225911532210525 16.8949;44.9033 6.46469;18.8755 58.9909;122.765 1 1 1 246273 TRIB3_10079 16.8949 16.8949 6.46469 6.46469 58.9909 58.9909 16.8949 6.46469 58.9909 1 24484 IGFBP3_8881 44.9033 44.9033 18.8755 18.8755 122.765 122.765 44.9033 18.8755 122.765 0 Exp 4,2(1) 1.9378180398591562 3.924032211303711 1.6548216342926025 2.2692105770111084 0.4344385876822888 1.9620161056518555 3.4508680000000034 58.347331999999994 0.5075012000000036 24.832688799999996 28.379332000000005 153.376568 CONFLICT 0.5 0.5 0.0 GO:0009892 5 negative regulation of metabolic process 589 626 36 34 16 24 12 12 40 614 1881 0.47427 0.65312 0.87212 1.92 24522;246273;299270;360918;24614;24484;25587;297417;24330;25695;58919;24188 zfp354a;trib3;serpina6;pf4;orm1;igfbp3;id2;gfpt1;egr1;cebpd;ccnd1;aldh1a1 ZFP354A_10203;TRIB3_10079;SERPINA6_32325;PF4_32963;ORM1_9400;IGFBP3_8881;ID2_8861;GFPT1_8705;EGR1_8533;CEBPD_8283;CCND1_8224;ALDH1A1_8022 159.76553083333332 30.8991 2.99674 296.3348370876628 109.10607502514861 203.38533211586062 93.1004445 11.91715 0.998544 173.24095464313777 63.99244834705077 126.90848829693523 530.731375 90.87795 6.6682 1202.2146227456772 286.56973703000244 638.1120091910445 3.26713;16.8949;15.8474;179.631;56.9823;44.9033;2.99674;981.5;8.26335;5.66035;512.733;88.5069 1.71987;6.46469;7.7531;110.795;16.0812;18.8755;0.998544;554.87;1.51678;2.15795;330.024;65.9487 6.6682;58.9909;40.8362;426.677;262.985;122.765;10.914;4240.48;45.9052;16.35;1002.56;133.645 6 6 6 246273;360918;24614;25587;297417;24188 TRIB3_10079;PF4_32963;ORM1_9400;ID2_8861;GFPT1_8705;ALDH1A1_8022 221.0853066666667 72.7446 377.81268935152855 125.859689 41.01495 214.36553191499127 855.6153166666667 198.315 1665.0453213033093 16.8949;179.631;56.9823;2.99674;981.5;88.5069 6.46469;110.795;16.0812;0.998544;554.87;65.9487 58.9909;426.677;262.985;10.914;4240.48;133.645 6 24522;299270;24484;24330;25695;58919 ZFP354A_10203;SERPINA6_32325;IGFBP3_8881;EGR1_8533;CEBPD_8283;CCND1_8224 98.445755 12.055375000000002 203.5309177080041 60.34119999999999 4.955525 132.28438188524584 205.84743333333333 43.3707 392.43992507750613 3.26713;15.8474;44.9033;8.26335;5.66035;512.733 1.71987;7.7531;18.8755;1.51678;2.15795;330.024 6.6682;40.8362;122.765;45.9052;16.35;1002.56 0 Exp 2,1(0.09);Exp 4,6(0.5);Hill,2(0.17);Linear,1(0.09);Poly 2,2(0.17) 2.219188347910338 30.400164008140564 1.5232417583465576 6.495501518249512 1.6315193480926655 1.8364248275756836 -7.901687170236158 327.4327488369029 -4.919853061925664 191.12074206192565 -149.4855823446028 1210.9483323446025 CONFLICT 0.5 0.5 0.0 GO:0010647 6 positive regulation of cell communication 426 450 15 14 10 10 7 7 45 443 2052 0.27591 0.8384 0.58058 1.56 24614;24539;29200;24484;24424;289388;24330 orm1;lpl;inhba;igfbp3;gstm2;g0s2;egr1 ORM1_9400;LPL_32544;INHBA_33300;IGFBP3_8881;GSTM2_8759;G0S2_32729;EGR1_8533 145.21221 44.9033 3.28268 278.90323352359496 220.42041711180286 333.83551843486003 81.67575671428573 16.0812 0.808077 162.88857274955666 121.97410449608876 196.36227436523433 410.51211428571423 122.765 13.1174 788.1176537701872 641.659677676671 936.9702308315975 56.9823;769.435;130.168;44.9033;3.28268;3.45084;8.26335 16.0812;444.211;89.164;18.8755;0.808077;1.07374;1.51678 262.985;2183.16;231.33;122.765;13.1174;14.3222;45.9052 3 4 3 24614;24424;289388 ORM1_9400;GSTM2_8759;G0S2_32729 21.238606666666666 3.45084 30.95506064082145 5.987672333333333 1.07374 8.742260564391588 96.8082 14.3222 143.9145910929118 56.9823;3.28268;3.45084 16.0812;0.808077;1.07374 262.985;13.1174;14.3222 4 24539;29200;24484;24330 LPL_32544;INHBA_33300;IGFBP3_8881;EGR1_8533 238.1924125 87.53565 357.8249177380989 138.44182 54.01975 207.3384241919225 645.79005 177.0475 1027.7322174568026 769.435;130.168;44.9033;8.26335 444.211;89.164;18.8755;1.51678 2183.16;231.33;122.765;45.9052 0 Exp 2,1(0.15);Exp 4,3(0.43);Hill,2(0.29);Poly 2,1(0.15) 2.017660841505115 15.641812324523926 1.5846891403198242 5.289852619171143 1.3571604128038293 1.6902254819869995 -61.4021968114574 351.82661681145737 -38.99378666039651 202.34530008896792 -173.33361412025977 994.3578426916882 CONFLICT 0.42857142857142855 0.5714285714285714 0.0 GO:0032101 5 regulation of response to external stimulus 254 266 7 6 2 4 2 2 50 264 2231 0.078898 0.97813 0.16486 0.75 83619;24539 nfe2l2;lpl NFE2L2_9301;LPL_32544 388.03864999999996 388.03864999999996 6.6423 539.3758908095957 556.4700852018296 483.9298036475422 223.80865 223.80865 3.4063 311.69599254890176 321.1422614316668 279.6546583598844 1098.31415 1098.31415 13.4683 1534.203714154168 1577.401439346762 1376.49256260148 6.6423;769.435 3.4063;444.211 13.4683;2183.16 1 1 1 83619 NFE2L2_9301 6.6423 6.6423 3.4063 3.4063 13.4683 13.4683 6.6423 3.4063 13.4683 1 24539 LPL_32544 769.435 769.435 444.211 444.211 2183.16 2183.16 769.435 444.211 2183.16 0 Exp 2,1(0.5);Exp 4,1(0.5) 1.614605586069447 3.23259437084198 1.5423688888549805 1.6902254819869995 0.10455039964679097 1.61629718542099 -359.4981960000001 1135.575496 -208.179956 655.7972560000001 -1027.9837159999995 3224.612015999999 CONFLICT 0.5 0.5 0.0 GO:0031349 6 positive regulation of defense response 74 79 3 2 2 2 2 2 50 77 2418 0.78279 0.48429 0.67532 2.53 316351;24539 npas2;lpl NPAS2_9350;LPL_32544 451.94649999999996 451.94649999999996 134.458 448.9965425974903 466.5508970536858 448.52125750949256 250.46795 250.46795 56.7249 273.9940489255287 259.3800851752649 273.70401264840933 1251.8039999999999 1251.8039999999999 320.448 1317.1362865975561 1294.6461590776753 1315.7420325744426 134.458;769.435 56.7249;444.211 320.448;2183.16 0 2 0 2 316351;24539 NPAS2_9350;LPL_32544 451.94649999999996 451.94649999999996 448.9965425974903 250.46795 250.46795 273.9940489255287 1251.8039999999999 1251.8039999999999 1317.1362865975561 134.458;769.435 56.7249;444.211 320.448;2183.16 0 Exp 2,1(0.5);Hill,1(0.5) 1.786785805202405 3.579087972640991 1.6902254819869995 1.8888624906539917 0.1404575758230412 1.7895439863204956 -170.3309599999999 1074.2239599999998 -129.268428 630.204328 -573.6537599999999 3077.2617600000003 DOWN 0.0 1.0 0.0 GO:0010039 6 response to iron ion 30 31 5 5 3 5 3 3 49 28 2467 0.99677 0.024124 0.024124 9.68 116686;24296;58919 gsr;cyp1a1;ccnd1 GSR_8755;CYP1A1_8415;CCND1_8224 229.4254 100.909 74.6342 245.70304931375998 211.36826090786204 234.1059794820845 153.55786666666665 73.3629 57.2867 153.03539855805695 142.28882744080582 145.82802177036214 422.82466666666664 159.385 106.529 502.7606107486278 385.80616897047923 479.0802495067919 0.5 87.7716 74.6342;100.909;512.733 57.2867;73.3629;330.024 106.529;159.385;1002.56 2 1 2 116686;24296 GSR_8755;CYP1A1_8415 87.7716 87.7716 18.57908925432025 65.3248 65.3248 11.367590035711236 132.957 132.957 37.374836026396125 74.6342;100.909 57.2867;73.3629 106.529;159.385 1 58919 CCND1_8224 512.733 512.733 330.024 330.024 1002.56 1002.56 512.733 330.024 1002.56 0 Exp 2,1(0.34);Poly 2,2(0.67) 1.7981388335981259 5.42249858379364 1.555469274520874 1.9608341455459595 0.21996770458210071 1.9061951637268066 -48.613774457542036 507.46457445754197 -19.6179892972836 326.7337226306169 -146.10252228250886 991.7518556158421 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0007165 4 signal transduction 714 752 29 28 16 19 12 12 40 740 1755 0.19176 0.88367 0.35818 1.6 246273;170698;363140;360918;83619;24539;29200;289388;24330;58919;64392;114628 trib3;slco1a2;rassf1;pf4;nfe2l2;lpl;inhba;g0s2;egr1;ccnd1;aldh1l1;abcg5 TRIB3_10079;SLCO1A2_9886;RASSF1_32475;PF4_32963;NFE2L2_9301;LPL_32544;INHBA_33300;G0S2_32729;EGR1_8533;CCND1_8224;ALDH1L1_32662;ABCG5_7947 280.81594916666666 181.8305 3.45084 284.33501203984986 420.4221961585464 304.1747849816366 175.6922925 110.9745 1.07374 171.7195484325785 260.06720935127123 176.87798491860818 613.9816333333333 477.6325 13.4683 644.6972454234599 847.5500698986974 718.2419371365224 16.8949;440.994;756.581;179.631;6.6423;769.435;130.168;3.45084;8.26335;512.733;184.03;360.968 6.46469;299.351;437.5;110.795;3.4063;444.211;89.164;1.07374;1.51678;330.024;111.154;273.647 58.9909;772.521;940.187;426.677;13.4683;2183.16;231.33;14.3222;45.9052;1002.56;1150.07;528.588 6 6 6 246273;363140;360918;83619;289388;64392 TRIB3_10079;RASSF1_32475;PF4_32963;NFE2L2_9301;G0S2_32729;ALDH1L1_32662 191.20500666666666 98.26295 289.66687255107564 111.73228833333333 58.629845 168.03982636140452 433.95256666666666 242.83395000000002 502.52230364412947 16.8949;756.581;179.631;6.6423;3.45084;184.03 6.46469;437.5;110.795;3.4063;1.07374;111.154 58.9909;940.187;426.677;13.4683;14.3222;1150.07 6 170698;24539;29200;24330;58919;114628 SLCO1A2_9886;LPL_32544;INHBA_33300;EGR1_8533;CCND1_8224;ABCG5_7947 370.4268916666667 400.981 273.2817053270314 239.65229666666664 286.499 163.75966208985682 794.0106999999999 650.5545 764.2527087796417 440.994;769.435;130.168;8.26335;512.733;360.968 299.351;444.211;89.164;1.51678;330.024;273.647 772.521;2183.16;231.33;45.9052;1002.56;528.588 0 Exp 2,3(0.25);Exp 4,3(0.25);Hill,1(0.09);Linear,1(0.09);Poly 2,4(0.34) 2.007604832307769 25.703885674476624 1.5423688888549805 5.289852619171143 1.0242742542733456 1.8105745911598206 119.93827134024875 441.69362699308465 78.53281153758319 272.85177346241676 249.20982770610937 978.7534389605573 CONFLICT 0.5 0.5 0.0 GO:0019878 10 lysine biosynthetic process via aminoadipic acid 1 1 1 1 1 1 1 1 51 0 2495 1.0 0.020416 0.020416 100.0 296925 aass AASS_7936 28.5735 28.5735 28.5735 28.573500000000003 6.14642 6.14642 6.14642 6.14642 128.079 128.079 128.079 128.079 0.0 28.5735 0.0 28.5735 28.5735 6.14642 128.079 0 1 0 1 296925 AASS_7936 28.5735 28.5735 6.14642 6.14642 128.079 128.079 28.5735 6.14642 128.079 0 Hill,1(1) 1.6175053119659424 1.6175053119659424 1.6175053119659424 1.6175053119659424 0.0 1.6175053119659424 28.5735 28.5735 6.14642 6.14642 128.079 128.079 DOWN 0.0 1.0 0.0 GO:0033512 10 L-lysine catabolic process to acetyl-CoA via saccharopine 1 1 1 1 1 1 1 1 51 0 2495 1.0 0.020416 0.020416 100.0 296925 aass AASS_7936 28.5735 28.5735 28.5735 28.573500000000003 6.14642 6.14642 6.14642 6.14642 128.079 128.079 128.079 128.079 0.0 28.5735 0.0 28.5735 28.5735 6.14642 128.079 0 1 0 1 296925 AASS_7936 28.5735 28.5735 6.14642 6.14642 128.079 128.079 28.5735 6.14642 128.079 0 Hill,1(1) 1.6175053119659424 1.6175053119659424 1.6175053119659424 1.6175053119659424 0.0 1.6175053119659424 28.5735 28.5735 6.14642 6.14642 128.079 128.079 DOWN 0.0 1.0 0.0 GO:0048609 3 multicellular organismal reproductive process 128 145 9 9 5 7 4 4 48 141 2354 0.82895 0.34332 0.53671 2.76 116686;24330;24296;24188 gsr;egr1;cyp1a1;aldh1a1 GSR_8755;EGR1_8533;CYP1A1_8415;ALDH1A1_8022 68.0783625 81.57055 8.26335 41.29564395408181 75.14380993686869 38.10493844650194 49.52877 61.6177 1.51678 32.67525320333826 54.888765352092335 29.83707451518847 111.36605 120.087 45.9052 48.68501175115398 120.59254882395382 46.67522406462573 74.6342;8.26335;100.909;88.5069 57.2867;1.51678;73.3629;65.9487 106.529;45.9052;159.385;133.645 3 1 3 116686;24296;24188 GSR_8755;CYP1A1_8415;ALDH1A1_8022 88.0167 88.5069 13.14425733124555 65.53276666666666 65.9487 8.046166914334641 133.18633333333332 133.645 26.43098494822578 74.6342;100.909;88.5069 57.2867;73.3629;65.9487 106.529;159.385;133.645 1 24330 EGR1_8533 8.26335 8.26335 1.51678 1.51678 45.9052 45.9052 8.26335 1.51678 45.9052 0 Hill,1(0.25);Poly 2,3(0.75) 2.727541163329069 11.956078886985779 1.9061951637268066 5.289852619171143 1.5874024175635173 2.380015552043915 27.608631424999842 108.54809357500015 17.5070218607285 81.55051813927149 63.65473848386912 159.07736151613088 UP 0.75 0.25 0.0 GO:1902533 7 positive regulation of intracellular signal transduction 254 269 6 5 3 3 2 2 50 267 2228 0.075201 0.97937 0.16603 0.74 24484;24424 igfbp3;gstm2 IGFBP3_8881;GSTM2_8759 24.09299 24.09299 3.28268 29.430222639188447 40.67416626845508 17.783902600414933 9.8417885 9.8417885 0.808077 12.775597321865796 17.0396420033774 7.719954457009448 67.9412 67.9412 13.1174 77.5325615008301 111.62354262279263 46.85086956343401 44.9033;3.28268 18.8755;0.808077 122.765;13.1174 1 1 1 24424 GSTM2_8759 3.28268 3.28268 0.808077 0.808077 13.1174 13.1174 3.28268 0.808077 13.1174 1 24484 IGFBP3_8881 44.9033 44.9033 18.8755 18.8755 122.765 122.765 44.9033 18.8755 122.765 0 Exp 4,1(0.5);Hill,1(0.5) 1.680170870993385 3.3607300519943237 1.6548216342926025 1.7059084177017212 0.03612381097759621 1.6803650259971619 -16.6952176 64.88119760000001 -7.864286039999996 27.547863039999996 -39.51344799999998 175.395848 CONFLICT 0.5 0.5 0.0 GO:0016043 4 cellular component organization 805 877 22 20 10 14 8 8 44 869 1626 0.0017167 0.99946 0.0028862 0.91 24522;308843;360918;338475;25333;24539;29276;114628 zfp354a;tsku;pf4;nrep;mgp;lpl;csrp1;abcg5 ZFP354A_10203;TSKU_10094;PF4_32963;NREP_9364;MGP_33209;LPL_32544;CSRP1_8396;ABCG5_7947 235.05636124999998 146.1275 3.26713 259.20429553719936 262.7744236824705 292.56983819226724 148.63840249999998 95.12845 1.46625 162.0749486789163 162.6293154585954 180.8373548194561 541.0177625 386.454 6.6682 697.7976999548956 635.1646450189485 805.7110167455656 3.26713;6.12626;179.631;112.624;75.1005;769.435;373.299;360.968 1.71987;1.46625;110.795;79.4619;13.9312;444.211;263.875;273.647 6.6682;41.3339;426.677;192.339;346.231;2183.16;603.145;528.588 1 7 1 360918 PF4_32963 179.631 179.631 110.795 110.795 426.677 426.677 179.631 110.795 426.677 7 24522;308843;338475;25333;24539;29276;114628 ZFP354A_10203;TSKU_10094;NREP_9364;MGP_33209;LPL_32544;CSRP1_8396;ABCG5_7947 242.97427 112.624 278.92569026894483 154.04460285714285 79.4619 174.280095820887 557.3521571428571 346.231 752.0538448507612 3.26713;6.12626;112.624;75.1005;769.435;373.299;360.968 1.71987;1.46625;79.4619;13.9312;444.211;263.875;273.647 6.6682;41.3339;192.339;346.231;2183.16;603.145;528.588 0 Exp 2,2(0.25);Exp 4,1(0.13);Hill,2(0.25);Linear,1(0.13);Poly 2,2(0.25) 2.2654866139910403 20.218638062477112 1.6902254819869995 6.495501518249512 1.617888512532619 1.939357042312622 55.436948464705125 414.6757740352948 36.32619313410311 260.95061186589686 57.46862667620718 1024.5668983237929 DOWN 0.125 0.875 0.0 GO:0032722 7 positive regulation of chemokine production 25 28 3 2 2 2 2 2 50 26 2469 0.98165 0.1104 0.1104 7.14 24539;24330 lpl;egr1 LPL_32544;EGR1_8533 388.84917499999995 388.84917499999995 8.26335 538.2296353619533 496.2955978620886 516.3348456284388 222.86389 222.86389 1.51678 313.0320849540894 285.3542761838818 300.29816762658226 1114.5326 1114.5326 45.9052 1511.2673622034981 1416.2258948104788 1449.790106116852 0.5 388.84917499999995 769.435;8.26335 444.211;1.51678 2183.16;45.9052 0 2 0 2 24539;24330 LPL_32544;EGR1_8533 388.84917499999995 388.84917499999995 538.2296353619533 222.86389 222.86389 313.0320849540894 1114.5326 1114.5326 1511.2673622034981 769.435;8.26335 444.211;1.51678 2183.16;45.9052 0 Exp 2,1(0.5);Hill,1(0.5) 2.99015780400947 6.980078101158142 1.6902254819869995 5.289852619171143 2.5453207584460262 3.490039050579071 -357.09904199999994 1134.797392 -210.9764456 656.7042256 -979.9771039999996 3209.0423039999996 DOWN 0.0 1.0 0.0 GO:0034764 6 positive regulation of transmembrane transport 60 63 5 5 4 3 2 2 50 61 2434 0.86411 0.37052 0.37052 3.17 83619;24424 nfe2l2;gstm2 NFE2L2_9301;GSTM2_8759 4.96249 4.96249 3.28268 2.375610084209949 5.861699854368932 2.0065808101872222 2.1071885 2.1071885 0.808077 1.8372211023348555 2.8026087336716676 1.5518256268229977 13.29285 13.29285 13.1174 0.24812376951838025 13.38676917475728 0.20958001389886344 6.6423;3.28268 3.4063;0.808077 13.4683;13.1174 2 0 2 83619;24424 NFE2L2_9301;GSTM2_8759 4.96249 4.96249 2.375610084209949 2.1071885 2.1071885 1.8372211023348555 13.29285 13.29285 0.24812376951838025 6.6423;3.28268 3.4063;0.808077 13.4683;13.1174 0 0 Exp 4,1(0.5);Hill,1(0.5) 1.6220789347929285 3.2482773065567017 1.5423688888549805 1.7059084177017212 0.11563990983958337 1.6241386532783508 1.6700624000000004 8.254917599999999 -0.43907003999999983 4.65344704 12.948968 13.636731999999999 UP 1.0 0.0 0.0 GO:0014912 8 negative regulation of smooth muscle cell migration 13 14 2 2 2 2 2 2 50 12 2483 0.99751 0.031809 0.031809 14.29 83619;24484 nfe2l2;igfbp3 NFE2L2_9301;IGFBP3_8881 25.7728 25.7728 6.6423 27.054612554978505 34.49513524904214 24.078907701692657 11.140899999999998 11.140899999999998 3.4063 10.938376219530943 14.667403448275861 9.73527714955239 68.11664999999999 68.11664999999999 13.4683 77.28443773131174 93.03294750957853 68.78401378426052 0.0 6.6423 0.5 25.7728 6.6423;44.9033 3.4063;18.8755 13.4683;122.765 1 1 1 83619 NFE2L2_9301 6.6423 6.6423 3.4063 3.4063 13.4683 13.4683 6.6423 3.4063 13.4683 1 24484 IGFBP3_8881 44.9033 44.9033 18.8755 18.8755 122.765 122.765 44.9033 18.8755 122.765 0 Exp 4,2(1) 1.597606148378587 3.197190523147583 1.5423688888549805 1.6548216342926025 0.07951609886198716 1.5985952615737915 -11.722980000000003 63.26858 -4.018915999999997 26.300715999999994 -38.99411599999999 175.22741599999998 CONFLICT 0.5 0.5 0.0 GO:2000112 7 regulation of cellular macromolecule biosynthetic process 538 577 29 25 14 20 13 13 39 564 1931 0.72403 0.39422 0.73756 2.25 24522;246273;360918;316351;83619;29200;494344;25587;297417;24330;289185;25695;58919 zfp354a;trib3;pf4;npas2;nfe2l2;inhba;ier2;id2;gfpt1;egr1;creg1;cebpd;ccnd1 ZFP354A_10203;TRIB3_10079;PF4_32963;NPAS2_9350;NFE2L2_9301;INHBA_33300;IER2_32643;ID2_8861;GFPT1_8705;EGR1_8533;CREG1_8380;CEBPD_8283;CCND1_8224 201.54433615384613 94.3216 2.99674 298.6424304945409 159.58342542238228 231.7383863675032 123.31036415384614 56.7249 0.998544 179.99181628685463 98.58817272678337 148.64522630663575 576.9352769230768 147.421 6.6682 1154.1307187227528 360.4215331483303 673.6648225162428 3.26713;16.8949;179.631;134.458;6.6423;130.168;543.54;2.99674;981.5;8.26335;94.3216;5.66035;512.733 1.71987;6.46469;110.795;56.7249;3.4063;89.164;375.947;0.998544;554.87;1.51678;69.2457;2.15795;330.024 6.6682;58.9909;426.677;320.448;13.4683;231.33;978.946;10.914;4240.48;45.9052;147.421;16.35;1002.56 6 7 6 246273;360918;83619;25587;297417;289185 TRIB3_10079;PF4_32963;NFE2L2_9301;ID2_8861;GFPT1_8705;CREG1_8380 213.6644233333333 55.60825 382.34270853340263 124.29670566666668 37.855195 215.54933627482143 816.3251999999999 103.20595 1684.6908492553437 16.8949;179.631;6.6423;2.99674;981.5;94.3216 6.46469;110.795;3.4063;0.998544;554.87;69.2457 58.9909;426.677;13.4683;10.914;4240.48;147.421 7 24522;316351;29200;494344;24330;25695;58919 ZFP354A_10203;NPAS2_9350;INHBA_33300;IER2_32643;EGR1_8533;CEBPD_8283;CCND1_8224 191.15569 130.168 237.234425128096 122.46492857142857 56.7249 161.4756043357438 371.74391428571425 231.33 438.6962928646326 3.26713;134.458;130.168;543.54;8.26335;5.66035;512.733 1.71987;56.7249;89.164;375.947;1.51678;2.15795;330.024 6.6682;320.448;231.33;978.946;45.9052;16.35;1002.56 0 Exp 2,1(0.08);Exp 4,4(0.31);Hill,3(0.24);Linear,2(0.16);Poly 2,3(0.24) 2.091945840274844 31.017359137535095 1.5232417583465576 6.495501518249512 1.5905769958563867 1.8309566974639893 39.20046165327497 363.8882106544173 25.465698256857593 221.1550300508347 -50.45732849909734 1204.327882345251 CONFLICT 0.46153846153846156 0.5384615384615384 0.0 GO:0051443 9 positive regulation of ubiquitin-protein transferase activity 9 9 1 1 1 1 1 1 51 8 2487 0.98657 0.16968 0.16968 11.11 246273 trib3 TRIB3_10079 16.8949 16.8949 16.8949 16.8949 6.46469 6.46469 6.46469 6.46469 58.9909 58.9909 58.9909 58.9909 0.0 16.8949 0.0 16.8949 16.8949 6.46469 58.9909 1 0 1 246273 TRIB3_10079 16.8949 16.8949 6.46469 6.46469 58.9909 58.9909 16.8949 6.46469 58.9909 0 0 Exp 4,1(1) 2.2692105770111084 2.2692105770111084 2.2692105770111084 2.2692105770111084 0.0 2.2692105770111084 16.8949 16.8949 6.46469 6.46469 58.9909 58.9909 UP 1.0 0.0 0.0 GO:0009624 5 response to nematode 1 1 1 1 1 1 1 1 51 0 2495 1.0 0.020416 0.020416 100.0 24296 cyp1a1 CYP1A1_8415 100.909 100.909 100.909 100.909 73.3629 73.3629 73.3629 73.3629 159.385 159.385 159.385 159.385 0.0 100.909 0.0 100.909 100.909 73.3629 159.385 1 0 1 24296 CYP1A1_8415 100.909 100.909 73.3629 73.3629 159.385 159.385 100.909 73.3629 159.385 0 0 Poly 2,1(1) 1.9061951637268066 1.9061951637268066 1.9061951637268066 1.9061951637268066 0.0 1.9061951637268066 100.909 100.909 73.3629 73.3629 159.385 159.385 UP 1.0 0.0 0.0 GO:0019341 5 dibenzo-p-dioxin catabolic process 1 1 1 1 1 1 1 1 51 0 2495 1.0 0.020416 0.020416 100.0 24296 cyp1a1 CYP1A1_8415 100.909 100.909 100.909 100.909 73.3629 73.3629 73.3629 73.3629 159.385 159.385 159.385 159.385 0.0 100.909 0.0 100.909 100.909 73.3629 159.385 1 0 1 24296 CYP1A1_8415 100.909 100.909 73.3629 73.3629 159.385 159.385 100.909 73.3629 159.385 0 0 Poly 2,1(1) 1.9061951637268066 1.9061951637268066 1.9061951637268066 1.9061951637268066 0.0 1.9061951637268066 100.909 100.909 73.3629 73.3629 159.385 159.385 UP 1.0 0.0 0.0 GO:0006488 6 dolichol-linked oligosaccharide biosynthetic process 1 1 1 1 1 1 1 1 51 0 2495 1.0 0.020416 0.020416 100.0 305291 srd5a3 SRD5A3_9939 169.209 169.209 169.209 169.209 105.547 105.547 105.547 105.547 459.211 459.211 459.211 459.211 0.0 169.209 0.0 169.209 169.209 105.547 459.211 1 0 1 305291 SRD5A3_9939 169.209 169.209 105.547 105.547 459.211 459.211 169.209 105.547 459.211 0 0 Poly 2,1(1) 1.5321133136749268 1.5321133136749268 1.5321133136749268 1.5321133136749268 0.0 1.5321133136749268 169.209 169.209 105.547 105.547 459.211 459.211 UP 1.0 0.0 0.0 GO:0016095 6 polyprenol catabolic process 1 1 1 1 1 1 1 1 51 0 2495 1.0 0.020416 0.020416 100.0 305291 srd5a3 SRD5A3_9939 169.209 169.209 169.209 169.209 105.547 105.547 105.547 105.547 459.211 459.211 459.211 459.211 0.0 169.209 0.0 169.209 169.209 105.547 459.211 1 0 1 305291 SRD5A3_9939 169.209 169.209 105.547 105.547 459.211 459.211 169.209 105.547 459.211 0 0 Poly 2,1(1) 1.5321133136749268 1.5321133136749268 1.5321133136749268 1.5321133136749268 0.0 1.5321133136749268 169.209 169.209 105.547 105.547 459.211 459.211 UP 1.0 0.0 0.0 GO:0044093 4 positive regulation of molecular function 417 443 11 10 6 6 4 4 48 439 2056 0.037734 0.98727 0.064731 0.9 246273;24424;24330;58919 trib3;gstm2;egr1;ccnd1 TRIB3_10079;GSTM2_8759;EGR1_8533;CCND1_8224 135.29348249999998 12.579125000000001 3.28268 251.68917355096517 229.9685349566782 287.970467295763 84.70338675 3.990735 0.808077 163.56643043436728 145.96174103845644 187.44395008562063 280.143375 52.44805 13.1174 481.9974381768183 464.1829129965343 548.3621857541106 16.8949;3.28268;8.26335;512.733 6.46469;0.808077;1.51678;330.024 58.9909;13.1174;45.9052;1002.56 2 2 2 246273;24424 TRIB3_10079;GSTM2_8759 10.08879 10.08879 9.625293069003146 3.6363835 3.6363835 3.9998294108479797 36.05415 36.05415 32.4374629267611 16.8949;3.28268 6.46469;0.808077 58.9909;13.1174 2 24330;58919 EGR1_8533;CCND1_8224 260.49817499999995 260.49817499999995 356.71391041780424 165.77039 165.77039 232.28968293074104 524.2325999999999 524.2325999999999 676.4570963346604 8.26335;512.733 1.51678;330.024 45.9052;1002.56 0 Exp 2,1(0.25);Exp 4,1(0.25);Hill,2(0.5) 2.3756577834129304 10.820440888404846 1.555469274520874 5.289852619171143 1.7503314270987942 1.9875594973564148 -111.36190757994589 381.9488725799458 -75.59171507567991 244.99848857567991 -192.21411441328195 752.500864413282 CONFLICT 0.5 0.5 0.0 GO:0010038 5 response to metal ion 201 215 16 15 10 13 9 9 43 206 2289 0.99 0.027424 0.037134 4.19 24314;83619;25333;25587;24424;300850;116686;24296;58919 nqo1;nfe2l2;mgp;id2;gstm2;gsta4;gsr;cyp1a1;ccnd1 NQO1_33055;NFE2L2_9301;MGP_33209;ID2_8861;GSTM2_8759;GSTA4_8757;GSR_8755;CYP1A1_8415;CCND1_8224 100.6405688888889 74.6342 2.99674 160.0298074630033 132.5937359890578 171.03972724100535 63.541669000000006 16.4151 0.808077 104.54685408710765 81.81208868695904 113.17018099130401 206.8099 106.529 10.914 317.8569545080617 284.048255601148 337.14514446359425 24.1117;6.6423;75.1005;2.99674;3.28268;105.355;74.6342;100.909;512.733 16.4151;3.4063;13.9312;0.998544;0.808077;75.6422;57.2867;73.3629;330.024 37.0434;13.4683;346.231;10.914;13.1174;172.041;106.529;159.385;1002.56 7 2 7 24314;83619;25587;24424;300850;116686;24296 NQO1_33055;NFE2L2_9301;ID2_8861;GSTM2_8759;GSTA4_8757;GSR_8755;CYP1A1_8415 45.41880285714286 24.1117 46.6507292004422 32.55997442857143 16.4151 34.75454031939157 73.21401428571428 37.0434 71.49925255950649 24.1117;6.6423;2.99674;3.28268;105.355;74.6342;100.909 16.4151;3.4063;0.998544;0.808077;75.6422;57.2867;73.3629 37.0434;13.4683;10.914;13.1174;172.041;106.529;159.385 2 25333;58919 MGP_33209;CCND1_8224 293.91675 293.91675 309.45290841762176 171.9776 171.9776 223.51136236424315 674.3955 674.3955 464.09468658938556 75.1005;512.733 13.9312;330.024 346.231;1002.56 0 Exp 2,1(0.12);Exp 4,2(0.23);Hill,3(0.34);Poly 2,3(0.34) 2.0370129647620834 19.512242674827576 1.5423688888549805 4.773829460144043 0.9968563942503853 1.9608341455459595 -3.9122386536066074 205.19337643138437 -4.7622756702436675 131.84561367024367 -0.8566436119336629 414.47644361193363 UP 0.7777777777777778 0.2222222222222222 0.0 GO:0014910 7 regulation of smooth muscle cell migration 45 50 4 4 4 3 3 3 49 47 2448 0.9822 0.0804 0.0804 6.0 83619;24484;24330 nfe2l2;igfbp3;egr1 NFE2L2_9301;IGFBP3_8881;EGR1_8533 19.936316666666666 8.26335 6.6423 21.637228180865343 27.093519597552763 22.830001908639204 7.932859999999999 3.4063 1.51678 9.523581211120112 10.956795900314324 10.176808975905693 60.71283333333333 45.9052 13.4683 56.13280379086131 79.73528323417153 56.76257099054419 1.5 26.583325000000002 6.6423;44.9033;8.26335 3.4063;18.8755;1.51678 13.4683;122.765;45.9052 1 2 1 83619 NFE2L2_9301 6.6423 6.6423 3.4063 3.4063 13.4683 13.4683 6.6423 3.4063 13.4683 2 24484;24330 IGFBP3_8881;EGR1_8533 26.583325000000002 26.583325000000002 25.90835710733604 10.19614 10.19614 12.274468624718544 84.3351 84.3351 54.348085780641796 44.9033;8.26335 18.8755;1.51678 122.765;45.9052 0 Exp 4,2(0.67);Hill,1(0.34) 2.3811915876826015 8.487043142318726 1.5423688888549805 5.289852619171143 2.1318900139691324 1.6548216342926025 -4.548511982223662 44.421145315557 -2.8440866647433385 18.70980666474334 -2.8074138495502297 124.23308051621689 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0017015 7 regulation of transforming growth factor beta receptor signaling pathway 30 31 2 2 2 2 2 2 50 29 2466 0.97588 0.13074 0.13074 6.45 338475;59107 nrep;ltbp1 NREP_9364;LTBP1_33264 555.7005 555.7005 112.624 626.6047954688026 610.5816440456017 621.7794542769902 293.30395 293.30395 79.4619 302.4183273156655 319.7912413572639 300.0894724736538 2629.1295 2629.1295 192.339 3446.1421737619153 2930.9596589893704 3419.604215699443 0.5 555.7005 112.624;998.777 79.4619;507.146 192.339;5065.92 0 2 0 2 338475;59107 NREP_9364;LTBP1_33264 555.7005 555.7005 626.6047954688026 293.30395 293.30395 302.4183273156655 2629.1295 2629.1295 3446.1421737619153 112.624;998.777 79.4619;507.146 192.339;5065.92 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.7319707458426024 3.468787908554077 1.6427439451217651 1.826043963432312 0.12961268593900602 1.7343939542770386 -312.72943999999995 1424.13044 -125.82646799999998 712.434368 -2146.97988 7405.23888 DOWN 0.0 1.0 0.0 GO:0051602 4 response to electrical stimulus 25 25 2 2 2 2 2 2 50 23 2472 0.98655 0.091027 0.091027 8.0 24314;24330 nqo1;egr1 NQO1_33055;EGR1_8533 16.187525 16.187525 8.26335 11.20647575561782 14.74761261753644 11.019909415367534 8.96594 8.96594 1.51678 10.534703100287162 7.612343225199813 10.359320487063862 41.4743 41.4743 37.0434 6.266238873518943 42.27944473436766 6.161918007685511 0.5 16.187525 24.1117;8.26335 16.4151;1.51678 37.0434;45.9052 1 1 1 24314 NQO1_33055 24.1117 24.1117 16.4151 16.4151 37.0434 37.0434 24.1117 16.4151 37.0434 1 24330 EGR1_8533 8.26335 8.26335 1.51678 1.51678 45.9052 45.9052 8.26335 1.51678 45.9052 0 Exp 4,1(0.5);Hill,1(0.5) 5.025221813335142 10.063682079315186 4.773829460144043 5.289852619171143 0.36488347499736634 5.031841039657593 0.6561420000000009 31.718908 -5.6344135999999985 23.566293599999998 32.789736 50.158864 CONFLICT 0.5 0.5 0.0 GO:0044260 4 cellular macromolecule metabolic process 676 733 29 28 11 19 8 8 44 725 1770 0.018469 0.99266 0.030311 1.09 246273;83619;307126;29200;24484;297417;24330;58919 trib3;nfe2l2;mcm10;inhba;igfbp3;gfpt1;egr1;ccnd1 TRIB3_10079;NFE2L2_9301;MCM10_32579;INHBA_33300;IGFBP3_8881;GFPT1_8705;EGR1_8533;CCND1_8224 239.33910625 87.53565 6.6423 344.95505919136406 180.37253563628403 235.16308833891435 140.93728375 54.01975 1.51678 200.5082065697349 108.25117081309399 145.771008539136 797.9493 177.0475 13.4683 1434.957284230381 477.8859228140211 765.01901485459 16.8949;6.6423;213.608;130.168;44.9033;981.5;8.26335;512.733 6.46469;3.4063;123.177;89.164;18.8755;554.87;1.51678;330.024 58.9909;13.4683;668.095;231.33;122.765;4240.48;45.9052;1002.56 3 5 3 246273;83619;297417 TRIB3_10079;NFE2L2_9301;GFPT1_8705 335.0124 16.8949 559.8981529412381 188.24699666666666 6.46469 317.50851699948623 1437.6463999999999 58.9909 2427.4318154676166 16.8949;6.6423;981.5 6.46469;3.4063;554.87 58.9909;13.4683;4240.48 5 307126;29200;24484;24330;58919 MCM10_32579;INHBA_33300;IGFBP3_8881;EGR1_8533;CCND1_8224 181.93513 130.168 201.27707696141653 112.551456 89.164 131.39450776594384 414.13104000000004 231.33 407.62942505406545 213.608;130.168;44.9033;8.26335;512.733 123.177;89.164;18.8755;1.51678;330.024 668.095;231.33;122.765;45.9052;1002.56 0 Exp 2,1(0.13);Exp 4,3(0.38);Hill,1(0.13);Linear,1(0.13);Poly 2,2(0.25) 1.9939125948520822 17.57470726966858 1.5232417583465576 5.289852619171143 1.2807709153007032 1.6452834606170654 0.2974459223560473 478.38076657764395 1.9921854519676572 279.88238204803235 -196.42536586448773 1792.3239658644877 DOWN 0.375 0.625 0.0 GO:0031669 5 cellular response to nutrient levels 87 92 11 11 4 9 4 4 48 88 2407 0.96242 0.11606 0.11606 4.35 83619;59107;24539;25612 nfe2l2;ltbp1;lpl;asns NFE2L2_9301;LTBP1_33264;LPL_32544;ASNS_8091 482.460325 462.21099999999996 6.6423 476.99718534315184 649.5280084962105 430.9890946935827 252.089475 248.9028 3.4063 260.26143794445585 347.99556051500235 233.71193824746203 1931.290825 1322.8874999999998 13.4683 2289.4242407508755 2566.6110907547754 2201.2022624299975 6.6423;998.777;769.435;154.987 3.4063;507.146;444.211;53.5946 13.4683;5065.92;2183.16;462.615 2 2 2 83619;25612 NFE2L2_9301;ASNS_8091 80.81465 80.81465 104.89554332308404 28.50045 28.50045 35.4884872662248 238.04165 238.04165 317.5946773175599 6.6423;154.987 3.4063;53.5946 13.4683;462.615 2 59107;24539 LTBP1_33264;LPL_32544 884.106 884.106 162.1692834108848 475.6785 475.6785 44.50176527397591 3624.54 3624.54 2038.4191445333322 998.777;769.435 507.146;444.211 5065.92;2183.16 0 Exp 2,2(0.5);Exp 4,2(0.5) 1.8326770387713147 7.509491205215454 1.5423688888549805 2.634152889251709 0.5082711029071053 1.6664847135543823 15.003083363711141 949.9175666362889 -2.966734185566736 507.1456841855667 -312.3449309358575 4174.926580935858 CONFLICT 0.5 0.5 0.0 GO:0044242 5 cellular lipid catabolic process 56 64 5 5 2 3 2 2 50 62 2433 0.85938 0.37794 0.37794 3.12 305291;24539 srd5a3;lpl SRD5A3_9939;LPL_32544 469.322 469.322 169.209 424.4238748444766 524.3390923522824 417.23118847492805 274.879 274.879 105.547 239.47161094376094 305.9211550622489 235.41329967990904 1321.1855 1321.1855 459.211 1219.016028319767 1479.2037486990316 1198.35743559953 169.209;769.435 105.547;444.211 459.211;2183.16 1 1 1 305291 SRD5A3_9939 169.209 169.209 105.547 105.547 459.211 459.211 169.209 105.547 459.211 1 24539 LPL_32544 769.435 769.435 444.211 444.211 2183.16 2183.16 769.435 444.211 2183.16 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.6092286860682363 3.2223387956619263 1.5321133136749268 1.6902254819869995 0.1118021864015754 1.6111693978309631 -118.89947999999987 1057.5434799999998 -57.01171999999991 606.76972 -368.2845199999995 3010.6555199999993 CONFLICT 0.5 0.5 0.0 GO:0071312 6 cellular response to alkaloid 21 22 3 3 2 2 2 2 50 20 2475 0.9906 0.072832 0.072832 9.09 24424;24330 gstm2;egr1 GSTM2_8759;EGR1_8533 5.773015000000001 5.773015000000001 3.28268 3.5218655318524 7.400743830592105 2.665433272953676 1.1624285 1.1624285 0.808077 0.5011286971472494 1.3940391679276314 0.3792663550972229 29.5113 29.5113 13.1174 23.18447572018829 40.22665503289473 17.54657366718741 0.5 5.773015000000001 3.28268;8.26335 0.808077;1.51678 13.1174;45.9052 1 1 1 24424 GSTM2_8759 3.28268 3.28268 0.808077 0.808077 13.1174 13.1174 3.28268 0.808077 13.1174 1 24330 EGR1_8533 8.26335 8.26335 1.51678 1.51678 45.9052 45.9052 8.26335 1.51678 45.9052 0 Hill,2(1) 3.0039980212119897 6.995761036872864 1.7059084177017212 5.289852619171143 2.534231248253234 3.497880518436432 0.8919584000000009 10.654071600000002 0.4678995600000002 1.85695744 -2.6207440000000055 61.64334400000001 CONFLICT 0.5 0.5 0.0 GO:0045475 4 locomotor rhythm 6 6 3 3 3 3 3 3 49 3 2492 1.0 1.5383E-4 1.5383E-4 50.0 316351;25587;24330 npas2;id2;egr1 NPAS2_9350;ID2_8861;EGR1_8533 48.572696666666666 8.26335 2.99674 74.4254545952998 75.52243280859734 77.9878855188985 19.746741333333333 1.51678 0.998544 32.02507308220865 31.17571507427369 33.79826661309331 125.75573333333334 45.9052 10.914 169.5137311376672 189.14479337452343 174.1898709563132 0.0 2.99674 0.0 2.99674 134.458;2.99674;8.26335 56.7249;0.998544;1.51678 320.448;10.914;45.9052 1 2 1 25587 ID2_8861 2.99674 2.99674 0.998544 0.998544 10.914 10.914 2.99674 0.998544 10.914 2 316351;24330 NPAS2_9350;EGR1_8533 71.360675 71.360675 89.23309276446294 29.120839999999998 29.120839999999998 39.038036028560654 183.17659999999998 183.17659999999998 194.1310756059421 134.458;8.26335 56.7249;1.51678 320.448;45.9052 0 Hill,3(1) 2.7035678919454043 9.156449317932129 1.8888624906539917 5.289852619171143 1.9384168972533682 1.9777342081069946 -35.64763357384031 132.7930269071736 -16.493040413734647 55.98652308040131 -66.06711134185994 317.5785780085266 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0032870 5 cellular response to hormone stimulus 198 212 25 23 16 16 12 12 40 200 2295 0.99978 8.3771E-4 8.3771E-4 5.66 286954;246273;24614;83619;59107;29200;24484;25587;297417;25315;24330;25612 ugt2b1;trib3;orm1;nfe2l2;ltbp1;inhba;igfbp3;id2;gfpt1;ephx1;egr1;asns UGT2B10_33303,UGT2B1_33224;TRIB3_10079;ORM1_9400;NFE2L2_9301;LTBP1_33264;INHBA_33300;IGFBP3_8881;ID2_8861;GFPT1_8705;EPHX1_8567;EGR1_8533;ASNS_8091 204.3741575 35.19995 2.99674 370.2058383874169 200.5447262985211 367.47867822668945 106.57862616666667 15.78395 0.998544 200.14366141024016 99.44336311937144 191.03627906439294 885.0608874999999 93.371375 10.914 1773.7652423350112 926.3204242350042 1860.3121584713756 9.5 568.2435 25.4966;16.8949;56.9823;6.6423;998.777;130.168;44.9033;2.99674;981.5;24.8784;8.26335;154.987 11.3392;6.46469;16.0812;3.4063;507.146;89.164;18.8755;0.998544;554.87;15.4867;1.51678;53.5946 63.97775;58.9909;262.985;13.4683;5065.92;231.33;122.765;10.914;4240.48;41.3795;45.9052;462.615 9 4 8 286954;246273;24614;83619;25587;297417;25315;25612 UGT2B10_33303,UGT2B1_33224;TRIB3_10079;ORM1_9400;NFE2L2_9301;ID2_8861;GFPT1_8705;EPHX1_8567;ASNS_8091 158.79728 25.1875 336.0453080088097 82.78015425 13.41295 191.46580413129564 644.35130625 61.484325 1461.5511028757064 25.4966;16.8949;56.9823;6.6423;2.99674;981.5;24.8784;154.987 11.3392;6.46469;16.0812;3.4063;0.998544;554.87;15.4867;53.5946 63.97775;58.9909;262.985;13.4683;10.914;4240.48;41.3795;462.615 4 59107;29200;24484;24330 LTBP1_33264;INHBA_33300;IGFBP3_8881;EGR1_8533 295.5279125 87.53565 471.6060520500424 154.17557 54.01975 238.34529839046462 1366.4800500000001 177.0475 2467.466084854395 998.777;130.168;44.9033;8.26335 507.146;89.164;18.8755;1.51678 5065.92;231.33;122.765;45.9052 0 Exp 2,1(0.08);Exp 4,8(0.62);Hill,2(0.16);Linear,1(0.08);Poly 2,1(0.08) 1.9943449862187883 27.792862057685852 1.5232417583465576 5.289852619171143 1.0256982631654705 1.6986740827560425 -5.0895141395753 413.8378291395753 -6.6633106892968215 219.82056302263015 -118.5412758384939 1888.6630508384942 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0071378 7 cellular response to growth hormone stimulus 5 5 3 3 3 2 2 2 50 3 2492 0.99992 0.0039313 0.0039313 40.0 286954;24614 ugt2b1;orm1 UGT2B10_33303,UGT2B1_33224;ORM1_9400 41.239450000000005 41.239450000000005 25.4966 22.263751980405264 47.05597516591896 20.688420003312526 13.7102 13.7102 11.3392 3.3531003563866033 14.58621553520448 3.1158426732042703 163.481375 163.481375 63.97775 140.71937598028657 200.24507019576583 130.76239599895268 0.0 25.4966 0.0 25.4966 25.4966;56.9823 11.3392;16.0812 63.97775;262.985 3 0 2 286954;24614 UGT2B10_33303,UGT2B1_33224;ORM1_9400 41.239450000000005 41.239450000000005 22.263751980405264 13.7102 13.7102 3.3531003563866033 163.481375 163.481375 140.71937598028657 25.4966;56.9823 11.3392;16.0812 63.97775;262.985 0 0 Exp 4,3(1) 1.6610782810537796 4.985977053642273 1.5846891403198242 1.7026138305664062 0.06697551951366207 1.6986740827560425 10.383464000000004 72.095436 9.06304 18.35736 -31.545729999999935 358.50847999999996 UP 1.0 0.0 0.0 GO:0006979 4 response to oxidative stress 170 179 9 9 6 7 5 5 47 174 2321 0.84566 0.30059 0.4096 2.79 24314;83619;116686;54232;24188 nqo1;nfe2l2;gsr;car3;aldh1a1 NQO1_33055;NFE2L2_9301;GSR_8755;CAR3_8196;ALDH1A1_8022 49.821020000000004 55.21 6.6423 34.15663666927702 57.993749229391526 35.05798432665311 33.543580000000006 24.6611 3.4063 26.89965833151046 42.08137102794929 27.716351028530486 79.47993999999998 106.529 13.4683 51.394542362083556 87.96437352594617 51.07247540070038 24.1117;6.6423;74.6342;55.21;88.5069 16.4151;3.4063;57.2867;24.6611;65.9487 37.0434;13.4683;106.529;106.714;133.645 4 1 4 24314;83619;116686;24188 NQO1_33055;NFE2L2_9301;GSR_8755;ALDH1A1_8022 48.473775 49.37295 39.28698653255511 35.7642 36.8509 30.527274197128484 72.671425 71.7862 56.68179722017613 24.1117;6.6423;74.6342;88.5069 16.4151;3.4063;57.2867;65.9487 37.0434;13.4683;106.529;133.645 1 54232 CAR3_8196 55.21 55.21 24.6611 24.6611 106.714 106.714 55.21 24.6611 106.714 0 Exp 4,2(0.4);Exp 5,1(0.2);Poly 2,2(0.4) 2.566400411004165 13.831045508384705 1.5423688888549805 4.773829460144043 1.2427963620824003 2.7548160552978516 19.881407901695955 79.76063209830406 9.964989876495824 57.122170123504176 34.430637365508325 124.52924263449168 UP 0.8 0.2 0.0 GO:0034976 5 response to endoplasmic reticulum stress 55 58 6 6 4 3 3 3 49 55 2440 0.9709 0.11318 0.11318 5.17 246273;83619;58919 trib3;nfe2l2;ccnd1 TRIB3_10079;NFE2L2_9301;CCND1_8224 178.7567333333333 16.8949 6.6423 289.27735648360607 276.4298909699266 306.8819423395049 113.29833 6.46469 3.4063 187.69616529130184 176.84308006933807 198.91799863140403 358.3397333333333 58.9909 13.4683 558.3752239898753 545.5840183584617 593.705757311109 1.5 264.81395 16.8949;6.6423;512.733 6.46469;3.4063;330.024 58.9909;13.4683;1002.56 2 1 2 246273;83619 TRIB3_10079;NFE2L2_9301 11.7686 11.7686 7.249682984793195 4.9354949999999995 4.9354949999999995 2.1626083085131285 36.229600000000005 36.229600000000005 32.18933915724272 16.8949;6.6423 6.46469;3.4063 58.9909;13.4683 1 58919 CCND1_8224 512.733 512.733 330.024 330.024 1002.56 1002.56 512.733 330.024 1002.56 0 Exp 2,1(0.34);Exp 4,2(0.67) 1.7591714338894002 5.367048740386963 1.5423688888549805 2.2692105770111084 0.4159120713617846 1.555469274520874 -148.59141155376236 506.104878220429 -99.09987585131542 325.69653585131545 -273.5213149902359 990.2007816569026 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0009887 4 animal organ morphogenesis 110 116 5 5 4 4 3 3 49 113 2382 0.78994 0.42511 0.51148 2.59 29200;25587;24188 inhba;id2;aldh1a1 INHBA_33300;ID2_8861;ALDH1A1_8022 73.89054666666668 88.5069 2.99674 64.83333001682492 84.1603974646384 50.94072383673914 52.03708133333333 65.9487 0.998544 45.699417483891914 60.45626564184681 35.88757887429281 125.29633333333334 133.645 10.914 110.44491133743256 137.2556418468108 87.81266145128204 130.168;2.99674;88.5069 89.164;0.998544;65.9487 231.33;10.914;133.645 2 1 2 25587;24188 ID2_8861;ALDH1A1_8022 45.75182 45.75182 60.46481399634667 33.473622 33.473622 45.92669574672413 72.2795 72.2795 86.78392236180619 2.99674;88.5069 0.998544;65.9487 10.914;133.645 1 29200 INHBA_33300 130.168 130.168 89.164 89.164 231.33 231.33 130.168 89.164 231.33 0 Hill,1(0.34);Poly 2,2(0.67) 2.0843581921893684 6.412676453590393 1.6357452869415283 2.79919695854187 0.5979656156086763 1.9777342081069946 0.5247272128261784 147.25636612050715 0.32332220051052474 103.75084046615615 0.31615072240292363 250.27651594426374 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0010646 5 regulation of cell communication 678 722 29 26 17 20 13 13 39 709 1786 0.35703 0.75322 0.64421 1.8 308843;246273;360918;24614;338475;83619;59107;24539;29200;24484;24424;289388;24330 tsku;trib3;pf4;orm1;nrep;nfe2l2;ltbp1;lpl;inhba;igfbp3;gstm2;g0s2;egr1 TSKU_10094;TRIB3_10079;PF4_32963;ORM1_9400;NREP_9364;NFE2L2_9301;LTBP1_33264;LPL_32544;INHBA_33300;IGFBP3_8881;GSTM2_8759;G0S2_32729;EGR1_8533 179.78314846153847 44.9033 3.28268 321.0680721636134 264.5420050177319 383.00082988318377 98.49772592307691 16.0812 0.808077 172.14614362032967 142.53111768908963 206.79971416738425 667.1010692307693 122.765 13.1174 1443.6375043001817 1010.7334796187237 1707.544926888535 6.12626;16.8949;179.631;56.9823;112.624;6.6423;998.777;769.435;130.168;44.9033;3.28268;3.45084;8.26335 1.46625;6.46469;110.795;16.0812;79.4619;3.4063;507.146;444.211;89.164;18.8755;0.808077;1.07374;1.51678 41.3339;58.9909;426.677;262.985;192.339;13.4683;5065.92;2183.16;231.33;122.765;13.1174;14.3222;45.9052 6 7 6 246273;360918;24614;83619;24424;289388 TRIB3_10079;PF4_32963;ORM1_9400;NFE2L2_9301;GSTM2_8759;G0S2_32729 44.48067 11.7686 69.27530690279849 23.1048345 4.9354949999999995 43.3274457066587 131.59346666666667 36.65655 173.98381690329327 16.8949;179.631;56.9823;6.6423;3.28268;3.45084 6.46469;110.795;16.0812;3.4063;0.808077;1.07374 58.9909;426.677;262.985;13.4683;13.1174;14.3222 7 308843;338475;59107;24539;29200;24484;24330 TSKU_10094;NREP_9364;LTBP1_33264;LPL_32544;INHBA_33300;IGFBP3_8881;EGR1_8533 295.75670142857143 112.624 410.08769871828156 163.12020428571427 79.4619 217.13598579845413 1126.1075857142857 192.339 1900.1008680900534 6.12626;112.624;998.777;769.435;130.168;44.9033;8.26335 1.46625;79.4619;507.146;444.211;89.164;18.8755;1.51678 41.3339;192.339;5065.92;2183.16;231.33;122.765;45.9052 0 Exp 2,2(0.16);Exp 4,5(0.39);Hill,3(0.24);Poly 2,3(0.24) 1.9596626089870148 27.14686369895935 1.5423688888549805 5.289852619171143 0.9969873796199117 1.7059084177017212 5.248556283342282 354.3177406397346 4.918016270375858 192.077435575778 -117.6692175443734 1451.8713560059116 CONFLICT 0.46153846153846156 0.5384615384615384 0.0 GO:0002072 6 optic cup morphogenesis involved in camera-type eye development 1 1 1 1 1 1 1 1 51 0 2495 1.0 0.020416 0.020416 100.0 24188 aldh1a1 ALDH1A1_8022 88.5069 88.5069 88.5069 88.5069 65.9487 65.9487 65.9487 65.9487 133.645 133.645 133.645 133.645 0.0 88.5069 0.0 88.5069 88.5069 65.9487 133.645 1 0 1 24188 ALDH1A1_8022 88.5069 88.5069 65.9487 65.9487 133.645 133.645 88.5069 65.9487 133.645 0 0 Poly 2,1(1) 2.79919695854187 2.79919695854187 2.79919695854187 2.79919695854187 0.0 2.79919695854187 88.5069 88.5069 65.9487 65.9487 133.645 133.645 UP 1.0 0.0 0.0 GO:0048869 3 cellular developmental process 541 573 29 27 14 21 10 10 42 563 1932 0.35338 0.7653 0.73697 1.75 308843;25333;29200;24484;494344;25587;24330;24296;25695;58919 tsku;mgp;inhba;igfbp3;ier2;id2;egr1;cyp1a1;cebpd;ccnd1 TSKU_10094;MGP_33209;INHBA_33300;IGFBP3_8881;IER2_32643;ID2_8861;EGR1_8533;CYP1A1_8415;CEBPD_8283;CCND1_8224 143.04005 60.0019 2.99674 207.8075663879326 134.2044146561733 191.58173319487156 90.7444124 16.40335 0.998544 142.12643226751806 82.0114115010578 130.8439809970584 295.57201 141.075 10.914 381.21154929526244 291.9941507370737 354.92132870408483 6.12626;75.1005;130.168;44.9033;543.54;2.99674;8.26335;100.909;5.66035;512.733 1.46625;13.9312;89.164;18.8755;375.947;0.998544;1.51678;73.3629;2.15795;330.024 41.3339;346.231;231.33;122.765;978.946;10.914;45.9052;159.385;16.35;1002.56 2 8 2 25587;24296 ID2_8861;CYP1A1_8415 51.952870000000004 51.952870000000004 69.23442300730035 37.180721999999996 37.180721999999996 51.16932684379743 85.14949999999999 85.14949999999999 104.9848509095479 2.99674;100.909 0.998544;73.3629 10.914;159.385 8 308843;25333;29200;24484;494344;24330;25695;58919 TSKU_10094;MGP_33209;INHBA_33300;IGFBP3_8881;IER2_32643;EGR1_8533;CEBPD_8283;CCND1_8224 165.811845 60.0019 227.75935627720273 104.135335 16.40335 156.75655940207125 348.1776375 177.0475 411.6490022089899 6.12626;75.1005;130.168;44.9033;543.54;8.26335;5.66035;512.733 1.46625;13.9312;89.164;18.8755;375.947;1.51678;2.15795;330.024 41.3339;346.231;231.33;122.765;978.946;45.9052;16.35;1002.56 0 Exp 2,1(0.1);Exp 4,2(0.2);Hill,4(0.4);Linear,1(0.1);Poly 2,2(0.2) 1.9939846160231545 21.552257537841797 1.555469274520874 5.289852619171143 1.1321983847743788 1.7805083990097046 14.239585938706739 271.8405140612932 2.653537030914677 178.8352877690853 59.29464383762121 531.8493761623788 DOWN 0.2 0.8 0.0 GO:1901605 7 alpha-amino acid metabolic process 67 72 10 10 6 7 3 3 49 69 2426 0.94267 0.18027 0.18027 4.17 297417;25612;296925 gfpt1;asns;aass GFPT1_8705;ASNS_8091;AASS_7936 388.3535 154.987 28.5735 517.5540272205889 148.42489570273463 331.36119453912676 204.87034000000003 53.5946 6.14642 304.035612957454 68.69709722540202 191.0951543839157 1610.391333333333 462.615 128.079 2283.85712769436 591.492497229036 1432.840667820891 981.5;154.987;28.5735 554.87;53.5946;6.14642 4240.48;462.615;128.079 2 1 2 297417;25612 GFPT1_8705;ASNS_8091 568.2435 568.2435 584.4329470388368 304.2323 304.2323 354.45523458199904 2351.5474999999997 2351.5474999999997 2671.353959907316 981.5;154.987 554.87;53.5946 4240.48;462.615 1 296925 AASS_7936 28.5735 28.5735 6.14642 6.14642 128.079 128.079 28.5735 6.14642 128.079 0 Exp 4,1(0.34);Hill,1(0.34);Linear,1(0.34) 1.8653135439632686 5.774899959564209 1.5232417583465576 2.634152889251709 0.6159790925444001 1.6175053119659424 -197.31401559452445 974.0210155945246 -139.1783442490692 548.9190242490693 -974.0363004980359 4194.8189671647015 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0006270 6 DNA replication initiation 12 13 1 1 1 1 1 1 51 12 2483 0.97238 0.2357 0.2357 7.69 307126 mcm10 MCM10_32579 213.608 213.608 213.608 213.608 123.177 123.177 123.177 123.177 668.095 668.095 668.095 668.095 0.0 213.608 213.608 123.177 668.095 0 1 0 1 307126 MCM10_32579 213.608 213.608 123.177 123.177 668.095 668.095 213.608 123.177 668.095 0 Poly 2,1(1) 2.103997230529785 2.103997230529785 2.103997230529785 2.103997230529785 0.0 2.103997230529785 213.608 213.608 123.177 123.177 668.095 668.095 DOWN 0.0 1.0 0.0 GO:0006749 5 glutathione metabolic process 22 29 6 6 3 6 3 3 49 26 2469 0.99748 0.020178 0.020178 10.34 24424;300850;116686 gstm2;gsta4;gsr GSTM2_8759;GSTA4_8757;GSR_8755 61.09062666666667 74.6342 3.28268 52.36660110721464 74.6536698847349 33.969115157528975 44.57899233333333 57.2867 0.808077 39.00193414307651 55.83693513891953 25.02098400893042 97.22913333333334 106.529 13.1174 79.86891322193716 112.77065673048011 53.8993467074185 0.5 38.95844 1.5 89.9946 3.28268;105.355;74.6342 0.808077;75.6422;57.2867 13.1174;172.041;106.529 3 0 3 24424;300850;116686 GSTM2_8759;GSTA4_8757;GSR_8755 61.09062666666667 74.6342 52.36660110721464 44.57899233333333 57.2867 39.00193414307651 97.22913333333334 106.529 79.86891322193716 3.28268;105.355;74.6342 0.808077;75.6422;57.2867 13.1174;172.041;106.529 0 0 Hill,1(0.34);Poly 2,2(0.67) 1.9062983166944876 5.737723112106323 1.7059084177017212 2.0709805488586426 0.1872596316290528 1.9608341455459595 1.832239024906265 120.34901430842709 0.4441490675476274 88.71383559911904 6.84894977813947 187.6093168885272 UP 1.0 0.0 0.0 GO:0006637 7 acyl-CoA metabolic process 29 31 5 3 2 3 2 2 50 29 2466 0.97588 0.13074 0.13074 6.45 24763;296925 acsm3;aass ACSM3_7976;AASS_7936 244.34925 244.34925 28.5735 305.15299208122633 193.9281252038102 296.7048515354933 168.97321 168.97321 6.14642 230.27185473567587 130.9248662970909 223.8967935597533 438.369 438.369 128.079 438.8163262687475 365.86237767098606 426.6677250939839 0.5 244.34925 460.125;28.5735 331.8;6.14642 748.659;128.079 0 2 0 2 24763;296925 ACSM3_7976;AASS_7936 244.34925 244.34925 305.15299208122633 168.97321 168.97321 230.27185473567587 438.369 438.369 438.8163262687475 460.125;28.5735 331.8;6.14642 748.659;128.079 0 Hill,1(0.5);Linear,1(0.5) 1.6190617940348266 3.2381250858306885 1.6175053119659424 1.620619773864746 0.002202257128391235 1.6190625429153442 -178.5712199999999 667.2697199999999 -150.1672984 488.1137184 -169.79939999999988 1046.5374 DOWN 0.0 1.0 0.0 GO:0001676 7 long-chain fatty acid metabolic process 44 52 8 8 5 7 4 4 48 48 2447 0.99633 0.020309 0.020309 7.69 24424;25315;499353;29277 gstm2;ephx1;cyp2c24;cyp2c11 GSTM2_8759;EPHX1_8567;CYP2C24_32875;CYP2C11_32593 223.00752 77.4062 3.28268 345.0814992864442 501.85266782005857 371.24963111573226 131.20284425 30.39865 0.808077 222.1085278390791 311.6250627392544 241.51972928095827 543.347475 198.26125 13.1174 828.234875663602 1209.9064037282392 887.8749350472883 1.5 77.4062 3.28268;24.8784;733.935;129.934 0.808077;15.4867;463.206;45.3106 13.1174;41.3795;1763.75;355.143 2 2 2 24424;25315 GSTM2_8759;EPHX1_8567 14.08054 14.08054 15.270480056605948 8.1473885 8.1473885 10.379353861780825 27.24845 27.24845 19.984322560572323 3.28268;24.8784 0.808077;15.4867 13.1174;41.3795 2 499353;29277 CYP2C24_32875;CYP2C11_32593 431.93449999999996 431.93449999999996 427.0932029434558 254.25830000000002 254.25830000000002 295.4966711666647 1059.4465 1059.4465 996.0355617268393 733.935;129.934 463.206;45.3106 1763.75;355.143 0 Exp 4,2(0.5);Hill,1(0.25);Linear,1(0.25) 1.879950331320881 7.6764233112335205 1.628912329673767 2.6370131969451904 0.4799561454591013 1.7052488923072815 -115.17234930071535 561.1873893007153 -86.4635130322975 348.8692015322975 -268.3227031503301 1355.0176531503303 CONFLICT 0.5 0.5 0.0 GO:0035094 5 response to nicotine 34 36 2 2 2 2 2 2 50 34 2461 0.96431 0.16634 0.16634 5.56 300850;116686 gsta4;gsr GSTA4_8757;GSR_8755 89.9946 89.9946 74.6342 21.722886003475665 83.07519076647243 19.39400237284589 66.46445 66.46445 57.2867 12.979298522069717 62.33014307485433 11.587804046599482 139.285 139.285 106.529 46.32397944909313 124.52938368444644 41.357643142426966 0.5 89.9946 105.355;74.6342 75.6422;57.2867 172.041;106.529 2 0 2 300850;116686 GSTA4_8757;GSR_8755 89.9946 89.9946 21.722886003475665 66.46445 66.46445 12.979298522069717 139.285 139.285 46.32397944909313 105.355;74.6342 75.6422;57.2867 172.041;106.529 0 0 Poly 2,2(1) 2.015154925796907 4.031814694404602 1.9608341455459595 2.0709805488586426 0.07788526870570663 2.015907347202301 59.888216000000014 120.100984 48.476060000000004 84.45284 75.08324 203.48676 UP 1.0 0.0 0.0 GO:0070995 4 NADPH oxidation 3 3 1 1 1 1 1 1 51 2 2493 0.99879 0.06003 0.06003 33.33 246248 fmo5 FMO5_33281 57.4978 57.4978 57.4978 57.497800000000005 31.5489 31.5489 31.5489 31.548900000000003 109.026 109.026 109.026 109.026 0.0 57.4978 0.0 57.4978 57.4978 31.5489 109.026 1 0 1 246248 FMO5_33281 57.4978 57.4978 31.5489 31.5489 109.026 109.026 57.4978 31.5489 109.026 0 0 Exp 5,1(1) 1.68118155002594 1.68118155002594 1.68118155002594 1.68118155002594 0.0 1.68118155002594 57.4978 57.4978 31.5489 31.5489 109.026 109.026 UP 1.0 0.0 0.0 GO:0071495 4 cellular response to endogenous stimulus 313 332 28 26 17 18 13 13 39 319 2176 0.99485 0.013316 0.019133 3.92 286954;246273;24614;83619;59107;29200;24484;25587;24424;297417;25315;24330;25612 ugt2b1;trib3;orm1;nfe2l2;ltbp1;inhba;igfbp3;id2;gstm2;gfpt1;ephx1;egr1;asns UGT2B10_33303,UGT2B1_33224;TRIB3_10079;ORM1_9400;NFE2L2_9301;LTBP1_33264;INHBA_33300;IGFBP3_8881;ID2_8861;GSTM2_8759;GFPT1_8705;EPHX1_8567;EGR1_8533;ASNS_8091 188.90558230769233 25.4966 2.99674 358.8062585644613 196.58138120359857 363.6459618057369 98.44243007692309 15.4867 0.808077 193.85543934681152 97.46160492126427 188.99940396778473 817.9883115384616 63.97775 10.914 1715.3832524557438 907.9725524842825 1839.9633678410014 25.4966;16.8949;56.9823;6.6423;998.777;130.168;44.9033;2.99674;3.28268;981.5;24.8784;8.26335;154.987 11.3392;6.46469;16.0812;3.4063;507.146;89.164;18.8755;0.998544;0.808077;554.87;15.4867;1.51678;53.5946 63.97775;58.9909;262.985;13.4683;5065.92;231.33;122.765;10.914;13.1174;4240.48;41.3795;45.9052;462.615 10 4 9 286954;246273;24614;83619;25587;24424;297417;25315;25612 UGT2B10_33303,UGT2B1_33224;TRIB3_10079;ORM1_9400;NFE2L2_9301;ID2_8861;GSTM2_8759;GFPT1_8705;EPHX1_8567;ASNS_8091 141.51788 24.8784 318.5872594512119 73.67214566666667 11.3392 181.17218954871325 574.2142055555555 58.9909 1383.252720608909 25.4966;16.8949;56.9823;6.6423;2.99674;3.28268;981.5;24.8784;154.987 11.3392;6.46469;16.0812;3.4063;0.998544;0.808077;554.87;15.4867;53.5946 63.97775;58.9909;262.985;13.4683;10.914;13.1174;4240.48;41.3795;462.615 4 59107;29200;24484;24330 LTBP1_33264;INHBA_33300;IGFBP3_8881;EGR1_8533 295.5279125 87.53565 471.6060520500424 154.17557 54.01975 238.34529839046462 1366.4800500000001 177.0475 2467.466084854395 998.777;130.168;44.9033;8.26335 507.146;89.164;18.8755;1.51678 5065.92;231.33;122.765;45.9052 0 Exp 2,1(0.08);Exp 4,8(0.58);Hill,3(0.22);Linear,1(0.08);Poly 2,1(0.08) 1.9722149416830663 29.498770475387573 1.5232417583465576 5.289852619171143 0.9921995800667933 1.7006439566612244 -6.14372168420374 383.95488629958834 -6.938587163181182 203.82344731702733 -114.5046466654378 1750.481269742361 UP 0.6923076923076923 0.3076923076923077 0.0 GO:0033197 6 response to vitamin E 15 17 2 2 2 2 2 2 50 15 2480 0.99554 0.045728 0.045728 11.76 24614;58919 orm1;ccnd1 ORM1_9400;CCND1_8224 284.85765 284.85765 56.9823 322.2644105005158 246.34472529434103 317.6284929543907 173.0526 173.0526 16.0812 221.99108278469205 146.52306221040638 218.79764186403165 632.7725 632.7725 262.985 522.9584976960408 570.275182301557 515.4355060271845 0.0 56.9823 0.5 284.85765 56.9823;512.733 16.0812;330.024 262.985;1002.56 1 1 1 24614 ORM1_9400 56.9823 56.9823 16.0812 16.0812 262.985 262.985 56.9823 16.0812 262.985 1 58919 CCND1_8224 512.733 512.733 330.024 330.024 1002.56 1002.56 512.733 330.024 1002.56 0 Exp 2,1(0.5);Exp 4,1(0.5) 1.5700112316268264 3.1401584148406982 1.555469274520874 1.5846891403198242 0.02066156525179856 1.5700792074203491 -161.77803599999987 731.4933359999998 -134.61134399999997 480.71654399999994 -92.01099999999974 1357.5559999999998 CONFLICT 0.5 0.5 0.0 GO:1901388 7 regulation of transforming growth factor beta activation 1 1 1 1 1 1 1 1 51 0 2495 1.0 0.020416 0.020416 100.0 59107 ltbp1 LTBP1_33264 998.777 998.777 998.777 998.7770000000002 507.146 507.146 507.146 507.14599999999996 5065.92 5065.92 5065.92 5065.92 0.0 998.777 0.0 998.777 998.777 507.146 5065.92 0 1 0 1 59107 LTBP1_33264 998.777 998.777 507.146 507.146 5065.92 5065.92 998.777 507.146 5065.92 0 Exp 2,1(1) 1.6427439451217651 1.6427439451217651 1.6427439451217651 1.6427439451217651 0.0 1.6427439451217651 998.777 998.777 507.146 507.146 5065.92 5065.92 DOWN 0.0 1.0 0.0 GO:0006139 4 nucleobase-containing compound metabolic process 359 401 20 17 7 13 5 5 47 396 2099 0.14929 0.93015 0.33333 1.25 307126;297417;24330;24763;296925 mcm10;gfpt1;egr1;acsm3;aass MCM10_32579;GFPT1_8705;EGR1_8533;ACSM3_7976;AASS_7936 338.41396999999995 213.608 8.26335 402.7872564048756 194.8619975798027 252.3888876799505 203.50204000000002 123.177 1.51678 237.75996714574174 119.91034401315537 163.91209231826198 1166.24364 668.095 45.9052 1746.8830982733066 550.686942248017 896.8354276561271 213.608;981.5;8.26335;460.125;28.5735 123.177;554.87;1.51678;331.8;6.14642 668.095;4240.48;45.9052;748.659;128.079 1 4 1 297417 GFPT1_8705 981.5 981.5 554.87 554.87 4240.48 4240.48 981.5 554.87 4240.48 4 307126;24330;24763;296925 MCM10_32579;EGR1_8533;ACSM3_7976;AASS_7936 177.6424625 121.09075 209.76236015406965 115.66005000000001 64.66171 154.6985280746338 397.68455 398.087 361.819816897504 213.608;8.26335;460.125;28.5735 123.177;1.51678;331.8;6.14642 668.095;45.9052;748.659;128.079 0 Hill,2(0.4);Linear,2(0.4);Poly 2,1(0.2) 2.1357818152650068 12.155216693878174 1.5232417583465576 5.289852619171143 1.6141935946202401 1.620619773864746 -14.644626830440302 691.4725668304402 -4.903759955470122 411.9078399554701 -364.9669077419471 2697.454187741947 DOWN 0.2 0.8 0.0 GO:1901361 5 organic cyclic compound catabolic process 75 89 12 12 7 9 5 5 47 84 2411 0.99142 0.033207 0.033207 5.62 286954;83619;24296;64392;26760 ugt2b1;nfe2l2;cyp1a1;aldh1l1;akr7a3 UGT2B10_33303,UGT2B1_33224;NFE2L2_9301;CYP1A1_8415;ALDH1L1_32662;AKR7A3_8015 67.3856 25.4966 6.6423 74.88957700351231 66.31670533620576 62.177527964149334 42.41188 12.797 3.4063 47.55899634156507 44.18379657216938 41.77399580413397 283.85109 63.97775 13.4683 487.47531513230797 196.70208004975888 364.81683318582515 3.5 142.4695 25.4966;6.6423;100.909;184.03;19.8501 11.3392;3.4063;73.3629;111.154;12.797 63.97775;13.4683;159.385;1150.07;32.3544 6 0 5 286954;83619;24296;64392;26760 UGT2B10_33303,UGT2B1_33224;NFE2L2_9301;CYP1A1_8415;ALDH1L1_32662;AKR7A3_8015 67.3856 25.4966 74.88957700351231 42.41188 12.797 47.55899634156507 283.85109 63.97775 487.47531513230797 25.4966;6.6423;100.909;184.03;19.8501 11.3392;3.4063;73.3629;111.154;12.797 63.97775;13.4683;159.385;1150.07;32.3544 0 0 Exp 4,4(0.67);Poly 2,2(0.34) 1.9879846151565341 12.732647180557251 1.5423688888549805 4.1214375495910645 0.986452926636229 1.7319857478141785 1.74199148546505 133.02920851453496 0.7245816855299125 84.0991783144701 -143.4398632596771 711.1420432596772 UP 1.0 0.0 0.0 GO:0042537 5 benzene-containing compound metabolic process 17 24 2 2 2 2 2 2 50 22 2473 0.98799 0.084821 0.084821 8.33 286954;24424 ugt2b1;gstm2 UGT2B10_33303,UGT2B1_33224;GSTM2_8759 14.38964 14.38964 3.28268 15.707613468735476 21.086899225186162 12.530864240925997 6.0736385 6.0736385 0.808077 7.446628486809618 9.248659417664248 5.9406026769473 38.547575 38.547575 13.1174 35.963698378521215 53.88142639739843 28.690305047284784 0.5 14.38964 25.4966;3.28268 11.3392;0.808077 63.97775;13.1174 3 0 2 286954;24424 UGT2B10_33303,UGT2B1_33224;GSTM2_8759 14.38964 14.38964 15.707613468735476 6.0736385 6.0736385 7.446628486809618 38.547575 38.547575 35.963698378521215 25.4966;3.28268 11.3392;0.808077 63.97775;13.1174 0 0 Exp 4,2(0.67);Hill,1(0.34) 1.7023962080334474 5.10719633102417 1.6986740827560425 1.7059084177017212 0.003621958938376603 1.7026138305664062 -7.3800016000000035 36.1592816 -4.246862039999997 16.39413904 -11.295567999999996 88.39071799999999 UP 1.0 0.0 0.0 GO:0008610 5 lipid biosynthetic process 109 122 17 15 6 14 6 6 46 116 2379 0.98921 0.035743 0.035743 4.92 305291;24539;24424;24296;24188;24763 srd5a3;lpl;gstm2;cyp1a1;aldh1a1;acsm3 SRD5A3_9939;LPL_32544;GSTM2_8759;CYP1A1_8415;ALDH1A1_8022;ACSM3_7976 265.24459666666667 135.059 3.28268 292.668965823989 313.5514776988082 310.22478388392045 170.27961283333335 89.45495 0.808077 175.6792199245651 196.90301083913866 178.68501506468564 616.1962333333333 309.298 13.1174 812.7487273431601 764.7608746262188 908.4516559926863 169.209;769.435;3.28268;100.909;88.5069;460.125 105.547;444.211;0.808077;73.3629;65.9487;331.8 459.211;2183.16;13.1174;159.385;133.645;748.659 4 2 4 305291;24424;24296;24188 SRD5A3_9939;GSTM2_8759;CYP1A1_8415;ALDH1A1_8022 90.476895 94.70795000000001 68.10356129265759 61.41666925 69.6558 43.909525460437195 191.33960000000002 146.515 189.62067647553624 169.209;3.28268;100.909;88.5069 105.547;0.808077;73.3629;65.9487 459.211;13.1174;159.385;133.645 2 24539;24763 LPL_32544;ACSM3_7976 614.78 614.78 218.71519848881078 388.0055 388.0055 79.48658037996132 1465.9095 1465.9095 1014.345384718883 769.435;460.125 444.211;331.8 2183.16;748.659 0 Exp 2,1(0.17);Hill,1(0.17);Linear,1(0.17);Poly 2,3(0.5) 1.8351808399103926 11.25425910949707 1.5321133136749268 2.79919695854187 0.46906807563530734 1.6980669498443604 31.060650926504934 499.4285424068284 29.706960073045053 310.8522655936217 -34.13819255513681 1266.5306592218035 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0003006 3 developmental process involved in reproduction 220 234 11 11 6 5 3 3 49 231 2264 0.28183 0.87051 0.62422 1.28 29200;116686;58919 inhba;gsr;ccnd1 INHBA_33300;GSR_8755;CCND1_8224 239.1784 130.168 74.6342 238.52691697475146 265.0058184233613 254.76486844675568 158.82489999999999 89.164 57.2867 149.11703271065318 175.30857666374231 158.99964882221462 446.80633333333327 231.33 106.529 485.32507241057857 497.94496728913396 519.4570411066533 130.168;74.6342;512.733 89.164;57.2867;330.024 231.33;106.529;1002.56 1 2 1 116686 GSR_8755 74.6342 74.6342 57.2867 57.2867 106.529 106.529 74.6342 57.2867 106.529 2 29200;58919 INHBA_33300;CCND1_8224 321.4505 321.4505 270.51430574463154 209.594 209.594 170.31373931659186 616.9449999999999 616.9449999999999 545.341962854501 130.168;512.733 89.164;330.024 231.33;1002.56 0 Exp 2,1(0.34);Poly 2,2(0.67) 1.7087269080192036 5.152048707008362 1.555469274520874 1.9608341455459595 0.21464997974224495 1.6357452869415283 -30.7402162597148 509.0970162597148 -9.916907593457495 327.5667075934575 -102.39068662008219 996.0033532867488 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0045786 6 negative regulation of cell cycle 105 115 5 5 4 3 3 3 49 112 2383 0.79425 0.41955 0.50781 2.61 363140;29200;58919 rassf1;inhba;ccnd1 RASSF1_32475;INHBA_33300;CCND1_8224 466.49399999999997 512.733 130.168 315.7559904150672 577.743519781079 268.6790090064528 285.56266666666664 330.024 89.164 178.37348414305677 347.6740810007819 146.78546097976746 724.6923333333334 940.187 231.33 428.4009707579257 853.5639204065678 324.86506549124397 756.581;130.168;512.733 437.5;89.164;330.024 940.187;231.33;1002.56 1 2 1 363140 RASSF1_32475 756.581 756.581 437.5 437.5 940.187 940.187 756.581 437.5 940.187 2 29200;58919 INHBA_33300;CCND1_8224 321.4505 321.4505 270.51430574463154 209.594 209.594 170.31373931659186 616.9449999999999 616.9449999999999 545.341962854501 130.168;512.733 89.164;330.024 231.33;1002.56 0 Exp 2,1(0.34);Poly 2,2(0.67) 1.77412154276992 5.385903596878052 1.555469274520874 2.1946890354156494 0.34820115231640564 1.6357452869415283 109.18246011382314 823.8055398861768 83.71406765754747 487.4112656757858 239.91099838848965 1209.473668278177 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0051707 4 response to other organism 231 253 11 9 5 7 4 4 48 249 2246 0.39964 0.77504 0.81417 1.58 360918;24539;24296;54232 pf4;lpl;cyp1a1;car3 PF4_32963;LPL_32544;CYP1A1_8415;CAR3_8196 276.29625 140.27 55.21 332.75106546824156 382.74695770689897 381.25801088917893 163.2575 92.07894999999999 24.6611 190.5930955995171 227.8122540115217 213.63473864587525 718.9839999999999 293.031 106.714 986.117020595764 1019.8049770970914 1146.7208553899904 179.631;769.435;100.909;55.21 110.795;444.211;73.3629;24.6611 426.677;2183.16;159.385;106.714 2 2 2 360918;24296 PF4_32963;CYP1A1_8415 140.27 140.27 55.664860028567325 92.07894999999999 92.07894999999999 26.468491744053082 293.031 293.031 189.00398575691466 179.631;100.909 110.795;73.3629 426.677;159.385 2 24539;54232 LPL_32544;CAR3_8196 412.3225 412.3225 505.03334079296184 234.43605 234.43605 296.66657933613794 1144.937 1144.937 1468.2690473676817 769.435;55.21 444.211;24.6611 2183.16;106.714 0 Exp 2,1(0.25);Exp 5,1(0.25);Poly 2,2(0.5) 2.0156597287355242 8.211028218269348 1.6902254819869995 2.7548160552978516 0.47715548411401965 1.8829933404922485 -49.79979415887675 602.3922941588767 -23.523733687526743 350.0387336875267 -247.41068018384874 1685.3786801838487 CONFLICT 0.5 0.5 0.0 GO:0048660 6 regulation of smooth muscle cell proliferation 79 82 5 5 4 4 3 3 49 79 2416 0.91588 0.23353 0.23353 3.66 24484;25587;24330 igfbp3;id2;egr1 IGFBP3_8881;ID2_8861;EGR1_8533 18.721130000000002 8.26335 2.99674 22.826822263615668 28.506495208792558 23.20181143181736 7.130274666666666 1.51678 0.998544 10.174963426764998 11.348754184423218 10.616104741561799 59.8614 45.9052 10.914 57.21663384960705 85.44458856233162 54.134666490823456 44.9033;2.99674;8.26335 18.8755;0.998544;1.51678 122.765;10.914;45.9052 1 2 1 25587 ID2_8861 2.99674 2.99674 0.998544 0.998544 10.914 10.914 2.99674 0.998544 10.914 2 24484;24330 IGFBP3_8881;EGR1_8533 26.583325000000002 26.583325000000002 25.90835710733604 10.19614 10.19614 12.274468624718544 84.3351 84.3351 54.348085780641796 44.9033;8.26335 18.8755;1.51678 122.765;45.9052 0 Exp 4,1(0.34);Hill,2(0.67) 2.5869471868395335 8.92240846157074 1.6548216342926025 5.289852619171143 2.011958049606758 1.9777342081069946 -7.10985107813881 44.552111078138815 -4.383780365270578 18.64432969860391 -4.885316352181974 124.60811635218198 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0044249 4 cellular biosynthetic process 372 415 37 34 19 27 13 13 39 402 2093 0.96603 0.068639 0.089284 3.13 305291;24539;29200;24424;297417;24330;29277;24296;25612;64392;24188;24763;296925 srd5a3;lpl;inhba;gstm2;gfpt1;egr1;cyp2c11;cyp1a1;asns;aldh1l1;aldh1a1;acsm3;aass SRD5A3_9939;LPL_32544;INHBA_33300;GSTM2_8759;GFPT1_8705;EGR1_8533;CYP2C11_32593;CYP1A1_8415;ASNS_8091;ALDH1L1_32662;ALDH1A1_8022;ACSM3_7976;AASS_7936 246.84026384615385 130.168 3.28268 304.7203403024867 237.9839490289684 280.9288665956034 144.87954438461537 73.3629 0.808077 179.94615123378443 143.77341464508262 166.6976405502411 793.1384307692307 355.143 13.1174 1194.4173528202214 652.467123743512 890.5327522480516 169.209;769.435;130.168;3.28268;981.5;8.26335;129.934;100.909;154.987;184.03;88.5069;460.125;28.5735 105.547;444.211;89.164;0.808077;554.87;1.51678;45.3106;73.3629;53.5946;111.154;65.9487;331.8;6.14642 459.211;2183.16;231.33;13.1174;4240.48;45.9052;355.143;159.385;462.615;1150.07;133.645;748.659;128.079 7 6 7 305291;24424;297417;24296;25612;64392;24188 SRD5A3_9939;GSTM2_8759;GFPT1_8705;CYP1A1_8415;ASNS_8091;ALDH1L1_32662;ALDH1A1_8022 240.34636857142854 154.987 332.54678421947426 137.8978967142857 73.3629 187.4698503151601 945.5033428571429 459.211 1500.8230878976892 169.209;3.28268;981.5;100.909;154.987;184.03;88.5069 105.547;0.808077;554.87;73.3629;53.5946;111.154;65.9487 459.211;13.1174;4240.48;159.385;462.615;1150.07;133.645 6 24539;29200;24330;29277;24763;296925 LPL_32544;INHBA_33300;EGR1_8533;CYP2C11_32593;ACSM3_7976;AASS_7936 254.416475 130.051 300.0300180904966 153.0248 67.2373 188.12680005757008 615.3793666666667 293.2365 806.5579869226556 769.435;130.168;8.26335;129.934;460.125;28.5735 444.211;89.164;1.51678;45.3106;331.8;6.14642 2183.16;231.33;45.9052;355.143;748.659;128.079 0 Exp 2,1(0.08);Exp 4,2(0.16);Hill,3(0.24);Linear,2(0.16);Poly 2,5(0.39) 1.9564983242105092 27.345026969909668 1.5232417583465576 5.289852619171143 1.0400268291062418 1.6902254819869995 81.192399937738 412.4881277545697 47.05970229324751 242.6993864759833 143.84576158471884 1442.4310999537424 CONFLICT 0.5384615384615384 0.46153846153846156 0.0 GO:0015718 8 monocarboxylic acid transport 51 54 5 5 4 4 3 3 49 51 2444 0.97697 0.096205 0.096205 5.56 170698;25598;140668 slco1a2;fabp2;abcc3 SLCO1A2_9886;FABP2_32859;ABCC3_7941 224.71030000000005 146.645 86.4919 189.70655767308094 192.10635881084764 178.19939512165575 145.21813333333333 95.8536 40.4498 136.32718255642686 120.89749759446273 129.0256898026579 400.0253333333333 319.535 108.02 339.4840424384234 334.5269659593782 327.5445344860533 1.5 293.8195 440.994;146.645;86.4919 299.351;95.8536;40.4498 772.521;319.535;108.02 2 1 2 25598;140668 FABP2_32859;ABCC3_7941 116.56845000000001 116.56845000000001 42.534664919392476 68.1517 68.1517 39.17640268350323 213.7775 213.7775 149.56369082267264 146.645;86.4919 95.8536;40.4498 319.535;108.02 1 170698 SLCO1A2_9886 440.994 440.994 299.351 299.351 772.521 772.521 440.994 299.351 772.521 0 Exp 2,1(0.34);Exp 5,1(0.34);Poly 2,1(0.34) 2.275047929665023 7.131215214729309 1.672735333442688 3.368933916091919 0.8838980204585964 2.089545965194702 10.03712100640243 439.3834789935976 -9.050596338426573 299.48686300509326 15.862974890017313 784.1876917766494 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0009889 5 regulation of biosynthetic process 634 681 37 33 15 27 14 14 38 667 1828 0.58373 0.54142 1.0 2.06 24522;246273;360918;316351;83619;59107;29200;494344;25587;297417;24330;289185;25695;58919 zfp354a;trib3;pf4;npas2;nfe2l2;ltbp1;inhba;ier2;id2;gfpt1;egr1;creg1;cebpd;ccnd1 ZFP354A_10203;TRIB3_10079;PF4_32963;NPAS2_9350;NFE2L2_9301;LTBP1_33264;INHBA_33300;IER2_32643;ID2_8861;GFPT1_8705;EGR1_8533;CREG1_8380;CEBPD_8283;CCND1_8224 258.4895264285714 112.2448 2.99674 357.38677282435896 259.66708234338216 355.9229934917716 150.7271952857143 62.985299999999995 0.998544 201.06847010178166 147.31347598924276 195.51663749842436 897.5770428571428 189.3755 6.6682 1633.6801411337804 921.6073053769945 1703.5160456711587 3.26713;16.8949;179.631;134.458;6.6423;998.777;130.168;543.54;2.99674;981.5;8.26335;94.3216;5.66035;512.733 1.71987;6.46469;110.795;56.7249;3.4063;507.146;89.164;375.947;0.998544;554.87;1.51678;69.2457;2.15795;330.024 6.6682;58.9909;426.677;320.448;13.4683;5065.92;231.33;978.946;10.914;4240.48;45.9052;147.421;16.35;1002.56 6 8 6 246273;360918;83619;25587;297417;289185 TRIB3_10079;PF4_32963;NFE2L2_9301;ID2_8861;GFPT1_8705;CREG1_8380 213.6644233333333 55.60825 382.34270853340263 124.29670566666668 37.855195 215.54933627482143 816.3251999999999 103.20595 1684.6908492553437 16.8949;179.631;6.6423;2.99674;981.5;94.3216 6.46469;110.795;3.4063;0.998544;554.87;69.2457 58.9909;426.677;13.4683;10.914;4240.48;147.421 8 24522;316351;59107;29200;494344;24330;25695;58919 ZFP354A_10203;NPAS2_9350;LTBP1_33264;INHBA_33300;IER2_32643;EGR1_8533;CEBPD_8283;CCND1_8224 292.10835375 132.313 360.2383521692866 170.5500625 72.94445 202.10616398657083 958.5159249999999 275.889 1708.6170099765918 3.26713;134.458;998.777;130.168;543.54;8.26335;5.66035;512.733 1.71987;56.7249;507.146;89.164;375.947;1.51678;2.15795;330.024 6.6682;320.448;5065.92;231.33;978.946;45.9052;16.35;1002.56 0 Exp 2,2(0.15);Exp 4,4(0.29);Hill,3(0.22);Linear,2(0.15);Poly 2,3(0.22) 2.056135943445532 32.66010308265686 1.5232417583465576 6.495501518249512 1.54103173284895 1.7368503212928772 71.2788862422725 445.70016661487034 45.40108958920095 256.0533009822276 41.80305137926814 1753.3510343350176 CONFLICT 0.42857142857142855 0.5714285714285714 0.0 GO:0060537 5 muscle tissue development 32 35 2 2 2 2 2 2 50 33 2462 0.96682 0.15908 0.15908 5.71 25587;29276 id2;csrp1 ID2_8861;CSRP1_8396 188.14786999999998 188.14786999999998 2.99674 261.843239134704 262.15818328569276 240.0142265268061 132.436772 132.436772 0.998544 185.8817246518871 184.97646987814048 170.3853745287647 307.0295 307.0295 10.914 418.7705561288902 425.39551226117044 383.85902746096366 0.5 188.14786999999998 2.99674;373.299 0.998544;263.875 10.914;603.145 1 1 1 25587 ID2_8861 2.99674 2.99674 0.998544 0.998544 10.914 10.914 2.99674 0.998544 10.914 1 29276 CSRP1_8396 373.299 373.299 263.875 263.875 603.145 603.145 373.299 263.875 603.145 0 Exp 2,1(0.5);Hill,1(0.5) 1.8927357243998804 3.7891244888305664 1.8113902807235718 1.9777342081069946 0.11762291906202094 1.8945622444152832 -174.74834479999996 551.0440848 -125.18215487999998 390.05569888 -273.35687999999993 887.4158799999999 CONFLICT 0.5 0.5 0.0 GO:0006633 6 fatty acid biosynthetic process 33 37 7 5 3 5 3 3 49 34 2461 0.9938 0.038289 0.038289 8.11 24539;24424;24763 lpl;gstm2;acsm3 LPL_32544;GSTM2_8759;ACSM3_7976 410.94756 460.125 3.28268 385.4363239421795 618.5503418648275 271.9981051570745 258.93969233333337 331.8 0.808077 230.50597900314202 377.3959384193792 143.3763065105409 981.6454666666665 748.659 13.1174 1103.6227805237863 1583.8426329103445 961.6033871426575 0.5 231.70384 769.435;3.28268;460.125 444.211;0.808077;331.8 2183.16;13.1174;748.659 1 2 1 24424 GSTM2_8759 3.28268 3.28268 0.808077 0.808077 13.1174 13.1174 3.28268 0.808077 13.1174 2 24539;24763 LPL_32544;ACSM3_7976 614.78 614.78 218.71519848881078 388.0055 388.0055 79.48658037996132 1465.9095 1465.9095 1014.345384718883 769.435;460.125 444.211;331.8 2183.16;748.659 0 Exp 2,1(0.34);Hill,1(0.34);Linear,1(0.34) 1.6718366062320316 5.016753673553467 1.620619773864746 1.7059084177017212 0.04539651573153829 1.6902254819869995 -25.214700151615318 847.1098201516154 -1.9023781601399605 519.7817628268067 -267.2212757949874 2230.5122091283206 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0009653 3 anatomical structure morphogenesis 282 299 9 9 6 7 5 5 47 294 2201 0.41638 0.74837 0.82769 1.67 308843;25333;29200;25587;24188 tsku;mgp;inhba;id2;aldh1a1 TSKU_10094;MGP_33209;INHBA_33300;ID2_8861;ALDH1A1_8022 60.57968000000001 75.1005 2.99674 55.03246323662788 65.78182548861797 45.230817160237564 34.301738799999995 13.9312 0.998544 40.66211017887325 32.154166936126565 36.03306910738682 152.69078 133.645 10.914 138.29831478200305 194.59993170394918 144.17847750928684 6.12626;75.1005;130.168;2.99674;88.5069 1.46625;13.9312;89.164;0.998544;65.9487 41.3339;346.231;231.33;10.914;133.645 2 3 2 25587;24188 ID2_8861;ALDH1A1_8022 45.75182 45.75182 60.46481399634667 33.473622 33.473622 45.92669574672413 72.2795 72.2795 86.78392236180619 2.99674;88.5069 0.998544;65.9487 10.914;133.645 3 308843;25333;29200 TSKU_10094;MGP_33209;INHBA_33300 70.46492 75.1005 62.150661838867 34.85381666666667 13.9312 47.44513415410302 206.2983 231.33 153.9821414994934 6.12626;75.1005;130.168 1.46625;13.9312;89.164 41.3339;346.231;231.33 0 Hill,3(0.6);Poly 2,2(0.4) 2.1240739113522253 10.796491503715515 1.6357452869415283 2.79919695854187 0.44116830247850686 2.0189225673675537 12.341599123587649 108.81776087641236 -1.34017224767031 69.94364984767032 31.466962253720638 273.91459774627936 DOWN 0.4 0.6 0.0 GO:0009968 6 negative regulation of signal transduction 284 297 14 13 8 8 6 6 46 291 2204 0.59574 0.57669 1.0 2.02 308843;360918;83619;59107;24424;24330 tsku;pf4;nfe2l2;ltbp1;gstm2;egr1 TSKU_10094;PF4_32963;NFE2L2_9301;LTBP1_33264;GSTM2_8759;EGR1_8533 200.453765 7.452825000000001 3.28268 397.21360264372396 332.32957218879034 502.7974562221506 104.1897345 2.46154 0.808077 202.16641613713983 168.6355170908811 255.79206814626897 934.4036333333333 43.619550000000004 13.1174 2030.3254442957511 1663.9404624967058 2560.5611020050055 6.12626;179.631;6.6423;998.777;3.28268;8.26335 1.46625;110.795;3.4063;507.146;0.808077;1.51678 41.3339;426.677;13.4683;5065.92;13.1174;45.9052 3 3 3 360918;83619;24424 PF4_32963;NFE2L2_9301;GSTM2_8759 63.18532666666667 6.6423 100.85890089712525 38.336459 3.4063 62.76438332028718 151.08756666666667 13.4683 238.66751476990606 179.631;6.6423;3.28268 110.795;3.4063;0.808077 426.677;13.4683;13.1174 3 308843;59107;24330 TSKU_10094;LTBP1_33264;EGR1_8533 337.7222033333333 8.26335 572.4912444181335 170.04301 1.51678 291.93975412493126 1717.7196999999999 45.9052 2899.62741759799 6.12626;998.777;8.26335 1.46625;507.146;1.51678 41.3339;5065.92;45.9052 0 Exp 2,1(0.17);Exp 4,1(0.17);Hill,3(0.5);Poly 2,1(0.17) 2.1564472870822424 14.405557870864868 1.5423688888549805 5.289852619171143 1.4446474819050827 1.7828499674797058 -117.38331248745322 518.2908424874533 -57.57708930329878 265.95655830329883 -690.1950744359532 2559.0023411026195 CONFLICT 0.5 0.5 0.0 GO:0042178 5 xenobiotic catabolic process 6 15 3 3 3 3 3 3 49 12 2483 0.99982 0.0030721 0.0030721 20.0 286954;24424;24296 ugt2b1;gstm2;cyp1a1 UGT2B10_33303,UGT2B1_33224;GSTM2_8759;CYP1A1_8415 43.229426666666676 25.4966 3.28268 51.17191070673571 73.0554109752327 47.03571651190908 28.503392333333334 11.3392 0.808077 39.20468988503896 50.99050325171858 37.55041357332603 78.82671666666666 63.97775 13.1174 74.25578469547564 122.56996818241619 63.313332359597766 0.0 3.28268 0.5 14.38964 25.4966;3.28268;100.909 11.3392;0.808077;73.3629 63.97775;13.1174;159.385 4 0 3 286954;24424;24296 UGT2B10_33303,UGT2B1_33224;GSTM2_8759;CYP1A1_8415 43.229426666666676 25.4966 51.17191070673571 28.503392333333334 11.3392 39.20468988503896 78.82671666666666 63.97775 74.25578469547564 25.4966;3.28268;100.909 11.3392;0.808077;73.3629 63.97775;13.1174;159.385 0 0 Exp 4,2(0.5);Hill,1(0.25);Poly 2,1(0.25) 1.7512063497315677 7.013391494750977 1.6986740827560425 1.9061951637268066 0.10194109835719889 1.7042611241340637 -14.677041519436806 101.13589485277015 -15.860890653567832 72.8676753202345 -5.201614007660041 162.8550473409934 UP 1.0 0.0 0.0 GO:0042905 9 9-cis-retinoic acid metabolic process 2 2 2 2 2 2 2 2 50 0 2495 1.0 4.0897E-4 4.0897E-4 100.0 24296;24188 cyp1a1;aldh1a1 CYP1A1_8415;ALDH1A1_8022 94.70795000000001 94.70795000000001 88.5069 8.769609010953614 96.07385540965416 8.554218084007049 69.6558 69.6558 65.9487 5.24263109707331 70.47236299241723 5.113866499903081 146.515 146.515 133.645 18.200928547741807 149.34987516182727 17.75389437936667 0.0 88.5069 0.0 88.5069 100.909;88.5069 73.3629;65.9487 159.385;133.645 2 0 2 24296;24188 CYP1A1_8415;ALDH1A1_8022 94.70795000000001 94.70795000000001 8.769609010953614 69.6558 69.6558 5.24263109707331 146.515 146.515 18.200928547741807 100.909;88.5069 73.3629;65.9487 159.385;133.645 0 0 Poly 2,2(1) 2.309938463399252 4.705392122268677 1.9061951637268066 2.79919695854187 0.6314476247254893 2.3526960611343384 82.553892 106.86200800000002 62.38988400000001 76.92171599999999 121.28980000000001 171.74019999999996 UP 1.0 0.0 0.0 GO:0048585 5 negative regulation of response to stimulus 377 396 19 18 10 10 7 7 45 389 2106 0.42693 0.72057 0.84682 1.77 308843;360918;83619;59107;24539;24424;24330 tsku;pf4;nfe2l2;ltbp1;lpl;gstm2;egr1 TSKU_10094;PF4_32963;NFE2L2_9301;LTBP1_33264;LPL_32544;GSTM2_8759;EGR1_8533 281.73679857142855 8.26335 3.28268 421.58122103617995 455.9934550349628 470.6046736927805 152.76420099999999 3.4063 0.808077 224.8904950157521 246.60008139382003 252.16992892579108 1112.7974 45.9052 13.1174 1912.578066387774 1810.8356963966235 2152.848151982719 6.12626;179.631;6.6423;998.777;769.435;3.28268;8.26335 1.46625;110.795;3.4063;507.146;444.211;0.808077;1.51678 41.3339;426.677;13.4683;5065.92;2183.16;13.1174;45.9052 3 4 3 360918;83619;24424 PF4_32963;NFE2L2_9301;GSTM2_8759 63.18532666666667 6.6423 100.85890089712525 38.336459 3.4063 62.76438332028718 151.08756666666667 13.4683 238.66751476990606 179.631;6.6423;3.28268 110.795;3.4063;0.808077 426.677;13.4683;13.1174 4 308843;59107;24539;24330 TSKU_10094;LTBP1_33264;LPL_32544;EGR1_8533 445.6504025 388.84917499999995 514.8703409517009 238.58500750000002 222.86389 274.97497166865367 1834.079775 1114.5326 2378.946148081824 6.12626;998.777;769.435;8.26335 1.46625;507.146;444.211;1.51678 41.3339;5065.92;2183.16;45.9052 0 Exp 2,2(0.29);Exp 4,1(0.15);Hill,3(0.43);Poly 2,1(0.15) 2.082693632217698 16.095783352851868 1.5423688888549805 5.289852619171143 1.3458560398602384 1.7059084177017212 -30.57494054604291 594.0485376889001 -13.837009169489392 319.36541116948945 -304.0602594644731 2529.655059464473 CONFLICT 0.42857142857142855 0.5714285714285714 0.0 GO:0006805 4 xenobiotic metabolic process 43 62 9 9 7 9 7 7 45 55 2440 0.99997 2.0323E-4 2.0323E-4 11.29 286954;501907;24424;300850;499353;29277;24296 ugt2b1;rgd1559459;gstm2;gsta4;cyp2c24;cyp2c11;cyp1a1 UGT2B10_33303,UGT2B1_33224;RGD1559459_9690;GSTM2_8759;GSTA4_8757;CYP2C24_32875;CYP2C11_32593;CYP1A1_8415 163.09889714285714 100.909 3.28268 255.96482835929763 221.33686441587056 303.34811257884223 98.61078242857143 45.3106 0.808077 163.40234588009673 138.9560244986631 192.45779389307896 374.43242142857144 159.385 13.1174 622.3039723932642 504.64373687841777 743.2879684201986 2.5 71.84450000000001 5.5 431.93449999999996 25.4966;42.78;3.28268;105.355;733.935;129.934;100.909 11.3392;20.6065;0.808077;75.6422;463.206;45.3106;73.3629 63.97775;93.6128;13.1174;172.041;1763.75;355.143;159.385 6 2 5 286954;501907;24424;300850;24296 UGT2B10_33303,UGT2B1_33224;RGD1559459_9690;GSTM2_8759;GSTA4_8757;CYP1A1_8415 55.564656 42.78 45.65120021300295 36.351775399999994 20.6065 35.53328696770714 100.42679 93.6128 66.33731634446409 25.4966;42.78;3.28268;105.355;100.909 11.3392;20.6065;0.808077;75.6422;73.3629 63.97775;93.6128;13.1174;172.041;159.385 2 499353;29277 CYP2C24_32875;CYP2C11_32593 431.93449999999996 431.93449999999996 427.0932029434558 254.25830000000002 254.25830000000002 295.4966711666647 1059.4465 1059.4465 996.0355617268393 733.935;129.934 463.206;45.3106 1763.75;355.143 0 Exp 4,4(0.5);Hill,1(0.13);Linear,1(0.13);Poly 2,2(0.25) 1.80484888298721 14.499889254570007 1.628912329673767 2.0820155143737793 0.18125428125556672 1.7052488923072815 -26.522501318192553 352.72029560390683 -22.43936940755134 219.6609342646942 -86.57681280667936 835.4416556638223 UP 0.7142857142857143 0.2857142857142857 0.0 GO:0032354 6 response to follicle-stimulating hormone 20 22 4 4 4 4 4 4 48 18 2477 0.99994 8.6149E-4 8.6149E-4 18.18 29200;25587;24330;25612 inhba;id2;egr1;asns INHBA_33300;ID2_8861;EGR1_8533;ASNS_8091 74.10377249999999 69.215675 2.99674 79.74222094123681 67.67451664575327 78.4792659329597 36.318481 27.55569 0.998544 43.010733188584815 32.9851932036703 42.696215007218036 187.69105000000002 138.6176 10.914 207.2364904383637 174.65653167594698 199.06535619108337 0.5 5.630045000000001 1.5 69.215675 130.168;2.99674;8.26335;154.987 89.164;0.998544;1.51678;53.5946 231.33;10.914;45.9052;462.615 2 2 2 25587;25612 ID2_8861;ASNS_8091 78.99186999999999 78.99186999999999 107.47334352030649 27.296572 27.296572 37.19102786126739 236.7645 236.7645 319.4008401687447 2.99674;154.987 0.998544;53.5946 10.914;462.615 2 29200;24330 INHBA_33300;EGR1_8533 69.215675 69.215675 86.19960467317266 45.34039 45.34039 61.975943614149195 138.6176 138.6176 131.11513348015936 130.168;8.26335 89.164;1.51678 231.33;45.9052 0 Exp 4,1(0.25);Hill,2(0.5);Poly 2,1(0.25) 2.5911469194582155 11.537485003471375 1.6357452869415283 5.289852619171143 1.6563018411349657 2.305943548679352 -4.043604022412069 152.25114902241205 -5.83203752481311 78.46899952481311 -15.400710629596404 390.78281062959644 CONFLICT 0.5 0.5 0.0