Gene Ontology Analyses GO Category: BP GO File Creation Date: 07/15/20 Deduplicate Gene Sets: true Data Source: Kidney_PFHxSAm_Female Work Source: Kidney_PFHxSAm_Female_williams_0.05_NOMTC_foldfilter1.5_BMD BMDExpress2 Version: BMDExpress 2.30.0507 BETA Timestamp (Start Time): 02/12/2021 22:59.29 Remove Promiscuous Probes: true Remove BMD > Highest Dose from Category Descriptive Statistics: true Remove BMD with p-Value < Cutoff: 0.1 Remove genes with BMDU/BMDL >: 40.0 Identify conflicting probe sets: 0.5 Category Count: 2479 Total Run Time: 0 seconds GO/Pathway/Gene Set/Gene ID GO Level GO/Pathway/Gene Set/Gene Name All Genes (Expression Data) All Genes (Platform) Input Genes Genes with BMD <= Highest Dose Genes with BMD p-Value >= Genes with BMDU/BMDL <= Genes That Passed All Filters Fisher's A Parameter Fisher's B Parameter Fisher's C Parameter Fisher's D Parameter Fisher's Exact Left P-Value Fisher's Exact Right P-Value Fisher's Exact Two Tail Percentage Entrez Gene IDs Gene Symbols Probe IDs Genes with Conflicting Probesets BMD Mean BMD Median BMD Minimum BMD Standard Deviation BMD wMean BMD wSD BMDL Mean BMDL Median BMDL Minimum BMDL Standard Deviation BMDL wMean BMDL wSD BMDU Mean BMDU Median BMDU Minimum BMDU Standard Deviation BMDU wMean BMDU wSD 5th Percentile Index BMD at 5th Percentile of Total Genes 10th Percentile Index BMD at 10th Percentile of Total Genes BMD List BMDL List BMDU List Probes with Adverse Direction Up Probes with Adverse Direction Down Genes with Adverse Direction Up Genes Up List Genes Up Probes List Genes Up BMD Mean Genes Up BMD Median Genes Up SD Genes Up BMDL Mean Genes Up BMDL Median Genes Up BMDL SD Genes Up BMDU Mean Genes Up BMDU Median Genes Up BMDU SD BMD list (up) BMDL List (up) BMDU List (up) Genes with Adverse Direction Down Genes Down List Genes Down Probes List Genes Down BMD Mean Genes Down BMD Median Genes Down SD Genes Down BMDL Mean Genes Down BMDL Median Genes Down BMDL SD Genes Down BMDU Mean Genes Down BMDU Median Genes Down BMDU SD BMD list (down) BMDL List (down) BMDU List (down) Genes with Adverse Conflict Count Genes Conflict List Genes Conflict Probes List BMD list (Conflict) BMDL list (Conflict) BMDU list (Conflict) Model Counts Mean Fold Change Total Fold Change Min Fold Change Max Fold Change Standard Deviation Fold Change Median Fold Change Lower bound of the 95% confidence interval - BMD Upper bound of the 95% confidence interval - BMD Lower bound of the 95% confidence interval - BMDL Upper bound of the 95% confidence interval - BMDL Lower bound of the 95% confidence interval - BMDU Upper bound of the 95% confidence interval - BMDU Overall Direction Percent Genes With Overall Direction Up Percent Genes With Overall Direction Down Percent Genes With Overall Direction Conflict GO:0000096 6 sulfur amino acid metabolic process 12 14 1 1 0 1 0 0 69 14 2464 0.68011 1.0 1.0 0.0 0 0 0 0 0 GO:0000097 6 sulfur amino acid biosynthetic process 4 5 1 1 0 1 0 0 69 5 2473 0.87159 1.0 1.0 0.0 0 0 0 0 0 GO:0001505 4 regulation of neurotransmitter levels 102 115 2 2 2 0 0 0 69 115 2363 0.039466 1.0 0.073312 0.0 0 0 0 0 0 GO:0001516 8 prostaglandin biosynthetic process 5 7 1 1 1 0 0 0 69 7 2471 0.82491 1.0 1.0 0.0 0 0 0 0 0 GO:0001578 6 microtubule bundle formation 6 7 1 1 1 0 0 0 69 7 2471 0.82491 1.0 1.0 0.0 0 0 0 0 0 GO:0001649 5 osteoblast differentiation 27 27 3 3 2 0 0 0 69 27 2451 0.47454 1.0 1.0 0.0 0 0 0 0 0 GO:0001816 5 cytokine production 29 29 1 1 1 0 0 0 69 29 2449 0.44891 1.0 1.0 0.0 0 0 0 0 0 GO:0001894 6 tissue homeostasis 38 39 1 1 1 0 0 0 69 39 2439 0.33983 1.0 0.62521 0.0 0 0 0 0 0 GO:0002041 5 intussusceptive angiogenesis 1 1 1 1 1 0 0 0 69 1 2477 0.97291 1.0 1.0 0.0 0 0 0 0 0 GO:0002541 7 activation of plasma proteins involved in acute inflammatory response 1 1 1 1 0 0 0 0 69 1 2477 0.97291 1.0 1.0 0.0 0 0 0 0 0 GO:0002673 7 regulation of acute inflammatory response 17 21 1 1 1 0 0 0 69 21 2457 0.56042 1.0 1.0 0.0 0 0 0 0 0 GO:0002675 8 positive regulation of acute inflammatory response 13 17 1 1 1 0 0 0 69 17 2461 0.62601 1.0 1.0 0.0 0 0 0 0 0 GO:0003009 7 skeletal muscle contraction 14 16 1 1 1 0 0 0 69 16 2462 0.64355 1.0 1.0 0.0 0 0 0 0 0 GO:0003179 4 heart valve morphogenesis 13 13 1 1 1 0 0 0 69 13 2465 0.69915 1.0 1.0 0.0 0 0 0 0 0 GO:0003181 5 atrioventricular valve morphogenesis 5 5 1 1 1 0 0 0 69 5 2473 0.87159 1.0 1.0 0.0 0 0 0 0 0 GO:0003278 8 apoptotic process involved in heart morphogenesis 2 2 1 1 1 0 0 0 69 2 2476 0.94654 1.0 1.0 0.0 0 0 0 0 0 GO:0003279 4 cardiac septum development 11 11 1 1 1 0 0 0 69 11 2467 0.73881 1.0 1.0 0.0 0 0 0 0 0 GO:0003281 5 ventricular septum development 10 10 1 1 1 0 0 0 69 10 2468 0.75947 1.0 1.0 0.0 0 0 0 0 0 GO:0006022 5 aminoglycan metabolic process 23 24 1 1 1 0 0 0 69 24 2454 0.51572 1.0 1.0 0.0 0 0 0 0 0 GO:0006026 6 aminoglycan catabolic process 3 3 1 1 1 0 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:0006027 7 glycosaminoglycan catabolic process 3 3 1 1 1 0 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:0006144 6 purine nucleobase metabolic process 4 6 1 1 1 0 0 0 69 6 2472 0.84794 1.0 1.0 0.0 0 0 0 0 0 GO:0006145 7 purine nucleobase catabolic process 2 2 1 1 1 0 0 0 69 2 2476 0.94654 1.0 1.0 0.0 0 0 0 0 0 GO:0006206 6 pyrimidine nucleobase metabolic process 9 10 1 1 1 0 0 0 69 10 2468 0.75947 1.0 1.0 0.0 0 0 0 0 0 GO:0006208 7 pyrimidine nucleobase catabolic process 4 5 1 1 1 0 0 0 69 5 2473 0.87159 1.0 1.0 0.0 0 0 0 0 0 GO:0006210 8 thymine catabolic process 2 3 1 1 1 0 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:0006212 7 uracil catabolic process 2 2 1 1 1 0 0 0 69 2 2476 0.94654 1.0 1.0 0.0 0 0 0 0 0 GO:0006213 6 pyrimidine nucleoside metabolic process 3 4 1 1 1 0 0 0 69 4 2474 0.8959 1.0 1.0 0.0 0 0 0 0 0 GO:0006214 9 thymidine catabolic process 1 1 1 1 1 0 0 0 69 1 2477 0.97291 1.0 1.0 0.0 0 0 0 0 0 GO:0006479 7 protein methylation 16 19 1 1 0 1 0 0 69 19 2459 0.59232 1.0 1.0 0.0 0 0 0 0 0 GO:0006555 7 methionine metabolic process 4 4 1 1 0 1 0 0 69 4 2474 0.8959 1.0 1.0 0.0 0 0 0 0 0 GO:0006577 5 amino-acid betaine metabolic process 12 13 1 1 0 1 0 0 69 13 2465 0.69915 1.0 1.0 0.0 0 0 0 0 0 GO:0006579 6 amino-acid betaine catabolic process 3 3 1 1 0 1 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:0006692 6 prostanoid metabolic process 9 14 1 1 1 0 0 0 69 14 2464 0.68011 1.0 1.0 0.0 0 0 0 0 0 GO:0006693 7 prostaglandin metabolic process 9 14 1 1 1 0 0 0 69 14 2464 0.68011 1.0 1.0 0.0 0 0 0 0 0 GO:0006706 6 steroid catabolic process 12 14 1 1 1 0 0 0 69 14 2464 0.68011 1.0 1.0 0.0 0 0 0 0 0 GO:0006775 5 fat-soluble vitamin metabolic process 10 13 1 1 1 0 0 0 69 13 2465 0.69915 1.0 1.0 0.0 0 0 0 0 0 GO:0006778 5 porphyrin-containing compound metabolic process 14 15 1 0 0 1 0 0 69 15 2463 0.66158 1.0 1.0 0.0 0 0 0 0 0 GO:0006779 6 porphyrin-containing compound biosynthetic process 8 8 1 0 0 1 0 0 69 8 2470 0.8025 1.0 1.0 0.0 0 0 0 0 0 GO:0006782 7 protoporphyrinogen IX biosynthetic process 4 4 1 0 0 1 0 0 69 4 2474 0.8959 1.0 1.0 0.0 0 0 0 0 0 GO:0006783 6 heme biosynthetic process 7 7 1 0 0 1 0 0 69 7 2471 0.82491 1.0 1.0 0.0 0 0 0 0 0 GO:0006919 10 activation of cysteine-type endopeptidase activity involved in apoptotic process 32 34 1 1 0 0 0 0 69 34 2444 0.39064 1.0 1.0 0.0 0 0 0 0 0 GO:0006936 5 muscle contraction 49 51 1 1 1 0 0 0 69 51 2427 0.24297 1.0 0.40139 0.0 0 0 0 0 0 GO:0006937 7 regulation of muscle contraction 34 35 2 2 2 0 0 0 69 35 2443 0.37991 1.0 1.0 0.0 0 0 0 0 0 GO:0006940 8 regulation of smooth muscle contraction 19 19 1 1 1 0 0 0 69 19 2459 0.59232 1.0 1.0 0.0 0 0 0 0 0 GO:0006941 6 striated muscle contraction 34 36 1 1 1 0 0 0 69 36 2442 0.36948 1.0 0.62432 0.0 0 0 0 0 0 GO:0007052 7 mitotic spindle organization 19 19 1 1 1 0 0 0 69 19 2459 0.59232 1.0 1.0 0.0 0 0 0 0 0 GO:0007566 3 embryo implantation 18 18 1 1 1 0 0 0 69 18 2460 0.60894 1.0 1.0 0.0 0 0 0 0 0 GO:0007597 5 blood coagulation, intrinsic pathway 1 1 1 1 0 1 0 0 69 1 2477 0.97291 1.0 1.0 0.0 0 0 0 0 0 GO:0007598 5 blood coagulation, extrinsic pathway 1 1 1 1 1 0 0 0 69 1 2477 0.97291 1.0 1.0 0.0 0 0 0 0 0 GO:0007613 6 memory 40 41 1 1 1 0 0 0 69 41 2437 0.32139 1.0 0.62707 0.0 0 0 0 0 0 GO:0008015 5 blood circulation 4 4 1 1 1 0 0 0 69 4 2474 0.8959 1.0 1.0 0.0 0 0 0 0 0 GO:0008213 7 protein alkylation 16 19 1 1 0 1 0 0 69 19 2459 0.59232 1.0 1.0 0.0 0 0 0 0 0 GO:0008217 4 regulation of blood pressure 48 54 1 1 1 0 0 0 69 54 2424 0.22336 1.0 0.40188 0.0 0 0 0 0 0 GO:0008608 4 attachment of spindle microtubules to kinetochore 5 7 1 1 1 0 0 0 69 7 2471 0.82491 1.0 1.0 0.0 0 0 0 0 0 GO:0009086 7 methionine biosynthetic process 4 4 1 1 0 1 0 0 69 4 2474 0.8959 1.0 1.0 0.0 0 0 0 0 0 GO:0009111 5 vitamin catabolic process 5 6 1 1 1 0 0 0 69 6 2472 0.84794 1.0 1.0 0.0 0 0 0 0 0 GO:0009112 6 nucleobase metabolic process 12 15 1 1 1 0 0 0 69 15 2463 0.66158 1.0 1.0 0.0 0 0 0 0 0 GO:0009116 6 nucleoside metabolic process 13 17 1 1 1 0 0 0 69 17 2461 0.62601 1.0 1.0 0.0 0 0 0 0 0 GO:0009120 7 deoxyribonucleoside metabolic process 3 3 1 1 1 0 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:0009164 7 nucleoside catabolic process 4 7 1 1 1 0 0 0 69 7 2471 0.82491 1.0 1.0 0.0 0 0 0 0 0 GO:0009755 5 hormone-mediated signaling pathway 41 44 1 1 0 1 0 0 69 44 2434 0.29556 1.0 0.6315 0.0 0 0 0 0 0 GO:0010042 6 response to manganese ion 14 14 1 1 1 0 0 0 69 14 2464 0.68011 1.0 1.0 0.0 0 0 0 0 0 GO:0010226 6 response to lithium ion 21 24 1 1 1 0 0 0 69 24 2454 0.51572 1.0 1.0 0.0 0 0 0 0 0 GO:0010335 5 response to non-ionic osmotic stress 1 1 1 1 1 0 0 0 69 1 2477 0.97291 1.0 1.0 0.0 0 0 0 0 0 GO:0010467 5 gene expression 44 44 1 1 1 0 0 0 69 44 2434 0.29556 1.0 0.6315 0.0 0 0 0 0 0 GO:0010517 7 regulation of phospholipase activity 14 15 1 1 1 0 0 0 69 15 2463 0.66158 1.0 1.0 0.0 0 0 0 0 0 GO:0010518 8 positive regulation of phospholipase activity 10 10 1 1 1 0 0 0 69 10 2468 0.75947 1.0 1.0 0.0 0 0 0 0 0 GO:0010575 7 positive regulation of vascular endothelial growth factor production 11 11 1 1 1 0 0 0 69 11 2467 0.73881 1.0 1.0 0.0 0 0 0 0 0 GO:0010594 6 regulation of endothelial cell migration 53 55 2 2 1 1 0 0 69 55 2423 0.21718 1.0 0.40255 0.0 0 0 0 0 0 GO:0010595 7 positive regulation of endothelial cell migration 35 36 1 1 1 0 0 0 69 36 2442 0.36948 1.0 0.62432 0.0 0 0 0 0 0 GO:0010596 7 negative regulation of endothelial cell migration 17 18 1 1 0 1 0 0 69 18 2460 0.60894 1.0 1.0 0.0 0 0 0 0 0 GO:0010633 6 negative regulation of epithelial cell migration 18 21 1 1 0 1 0 0 69 21 2457 0.56042 1.0 1.0 0.0 0 0 0 0 0 GO:0010640 6 regulation of platelet-derived growth factor receptor signaling pathway 7 7 1 1 0 0 0 0 69 7 2471 0.82491 1.0 1.0 0.0 0 0 0 0 0 GO:0010641 7 positive regulation of platelet-derived growth factor receptor signaling pathway 2 2 1 1 0 0 0 0 69 2 2476 0.94654 1.0 1.0 0.0 0 0 0 0 0 GO:0010656 9 negative regulation of muscle cell apoptotic process 23 27 1 1 0 1 0 0 69 27 2451 0.47454 1.0 1.0 0.0 0 0 0 0 0 GO:0010660 8 regulation of muscle cell apoptotic process 35 39 1 1 0 1 0 0 69 39 2439 0.33983 1.0 0.62521 0.0 0 0 0 0 0 GO:0010894 8 negative regulation of steroid biosynthetic process 5 5 1 1 0 1 0 0 69 5 2473 0.87159 1.0 1.0 0.0 0 0 0 0 0 GO:0010896 7 regulation of triglyceride catabolic process 9 11 1 1 0 1 0 0 69 11 2467 0.73881 1.0 1.0 0.0 0 0 0 0 0 GO:0010898 8 positive regulation of triglyceride catabolic process 5 7 1 1 0 1 0 0 69 7 2471 0.82491 1.0 1.0 0.0 0 0 0 0 0 GO:0010950 8 positive regulation of endopeptidase activity 54 58 2 2 1 0 0 0 69 58 2420 0.19963 1.0 0.40595 0.0 0 0 0 0 0 GO:0010952 7 positive regulation of peptidase activity 63 67 2 2 1 0 0 0 69 67 2411 0.15494 1.0 0.26079 0.0 0 0 0 0 0 GO:0014733 6 regulation of skeletal muscle adaptation 3 3 1 1 1 0 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:0014883 7 transition between fast and slow fiber 3 3 1 1 1 0 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:0014910 7 regulation of smooth muscle cell migration 45 50 1 1 0 0 0 0 69 50 2428 0.24988 1.0 0.64509 0.0 0 0 0 0 0 GO:0014911 8 positive regulation of smooth muscle cell migration 32 35 1 1 0 0 0 0 69 35 2443 0.37991 1.0 1.0 0.0 0 0 0 0 0 GO:0019371 7 cyclooxygenase pathway 3 3 1 1 1 0 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:0019439 5 aromatic compound catabolic process 57 68 1 1 1 0 0 0 69 68 2410 0.15063 1.0 0.2609 0.0 0 0 0 0 0 GO:0019482 6 beta-alanine metabolic process 3 4 1 1 1 0 0 0 69 4 2474 0.8959 1.0 1.0 0.0 0 0 0 0 0 GO:0019483 6 beta-alanine biosynthetic process 2 2 1 1 1 0 0 0 69 2 2476 0.94654 1.0 1.0 0.0 0 0 0 0 0 GO:0019859 7 thymine metabolic process 2 3 1 1 1 0 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:0019860 6 uracil metabolic process 3 3 1 1 1 0 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:0020027 5 hemoglobin metabolic process 8 8 1 0 0 1 0 0 69 8 2470 0.8025 1.0 1.0 0.0 0 0 0 0 0 GO:0022617 6 extracellular matrix disassembly 7 7 1 0 1 0 0 0 69 7 2471 0.82491 1.0 1.0 0.0 0 0 0 0 0 GO:0030031 6 cell projection assembly 41 43 1 1 0 1 0 0 69 43 2435 0.30393 1.0 0.62982 0.0 0 0 0 0 0 GO:0030194 6 positive regulation of blood coagulation 17 18 1 1 0 1 0 0 69 18 2460 0.60894 1.0 1.0 0.0 0 0 0 0 0 GO:0030203 6 glycosaminoglycan metabolic process 21 21 1 1 1 0 0 0 69 21 2457 0.56042 1.0 1.0 0.0 0 0 0 0 0 GO:0030212 7 hyaluronan metabolic process 14 14 1 1 1 0 0 0 69 14 2464 0.68011 1.0 1.0 0.0 0 0 0 0 0 GO:0030214 7 hyaluronan catabolic process 3 3 1 1 1 0 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:0030218 6 erythrocyte differentiation 14 16 1 0 0 1 0 0 69 16 2462 0.64355 1.0 1.0 0.0 0 0 0 0 0 GO:0030278 5 regulation of ossification 54 58 1 1 1 0 0 0 69 58 2420 0.19963 1.0 0.40595 0.0 0 0 0 0 0 GO:0030500 6 regulation of bone mineralization 18 20 1 1 1 0 0 0 69 20 2458 0.57616 1.0 1.0 0.0 0 0 0 0 0 GO:0030501 7 positive regulation of bone mineralization 11 12 1 1 1 0 0 0 69 12 2466 0.71871 1.0 1.0 0.0 0 0 0 0 0 GO:0030510 6 regulation of BMP signaling pathway 17 19 1 1 1 0 0 0 69 19 2459 0.59232 1.0 1.0 0.0 0 0 0 0 0 GO:0030513 7 positive regulation of BMP signaling pathway 10 11 1 1 1 0 0 0 69 11 2467 0.73881 1.0 1.0 0.0 0 0 0 0 0 GO:0030728 4 ovulation 14 18 1 1 1 0 0 0 69 18 2460 0.60894 1.0 1.0 0.0 0 0 0 0 0 GO:0030901 4 midbrain development 8 8 1 0 1 0 0 0 69 8 2470 0.8025 1.0 1.0 0.0 0 0 0 0 0 GO:0031330 7 negative regulation of cellular catabolic process 57 58 1 1 0 1 0 0 69 58 2420 0.19963 1.0 0.40595 0.0 0 0 0 0 0 GO:0031392 9 regulation of prostaglandin biosynthetic process 5 6 1 1 1 0 0 0 69 6 2472 0.84794 1.0 1.0 0.0 0 0 0 0 0 GO:0031394 10 positive regulation of prostaglandin biosynthetic process 5 6 1 1 1 0 0 0 69 6 2472 0.84794 1.0 1.0 0.0 0 0 0 0 0 GO:0031620 5 regulation of fever generation 3 5 1 1 1 0 0 0 69 5 2473 0.87159 1.0 1.0 0.0 0 0 0 0 0 GO:0031622 6 positive regulation of fever generation 3 5 1 1 1 0 0 0 69 5 2473 0.87159 1.0 1.0 0.0 0 0 0 0 0 GO:0031650 4 regulation of heat generation 6 8 1 1 1 0 0 0 69 8 2470 0.8025 1.0 1.0 0.0 0 0 0 0 0 GO:0031652 5 positive regulation of heat generation 6 8 1 1 1 0 0 0 69 8 2470 0.8025 1.0 1.0 0.0 0 0 0 0 0 GO:0031915 6 positive regulation of synaptic plasticity 6 6 1 1 1 0 0 0 69 6 2472 0.84794 1.0 1.0 0.0 0 0 0 0 0 GO:0031954 10 positive regulation of protein autophosphorylation 9 10 1 1 0 0 0 0 69 10 2468 0.75947 1.0 1.0 0.0 0 0 0 0 0 GO:0032025 6 response to cobalt ion 13 13 1 0 0 1 0 0 69 13 2465 0.69915 1.0 1.0 0.0 0 0 0 0 0 GO:0032225 7 regulation of synaptic transmission, dopaminergic 7 7 1 1 1 0 0 0 69 7 2471 0.82491 1.0 1.0 0.0 0 0 0 0 0 GO:0032227 7 negative regulation of synaptic transmission, dopaminergic 2 2 1 1 1 0 0 0 69 2 2476 0.94654 1.0 1.0 0.0 0 0 0 0 0 GO:0032259 3 methylation 34 41 1 1 0 1 0 0 69 41 2437 0.32139 1.0 0.62707 0.0 0 0 0 0 0 GO:0032435 11 negative regulation of proteasomal ubiquitin-dependent protein catabolic process 5 5 1 1 0 1 0 0 69 5 2473 0.87159 1.0 1.0 0.0 0 0 0 0 0 GO:0032507 5 maintenance of protein location in cell 15 15 1 1 0 1 0 0 69 15 2463 0.66158 1.0 1.0 0.0 0 0 0 0 0 GO:0032571 6 response to vitamin K 3 3 1 1 1 0 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:0032720 8 negative regulation of tumor necrosis factor production 19 19 1 1 0 0 0 0 69 19 2459 0.59232 1.0 1.0 0.0 0 0 0 0 0 GO:0032873 8 negative regulation of stress-activated MAPK cascade 7 7 1 1 0 1 0 0 69 7 2471 0.82491 1.0 1.0 0.0 0 0 0 0 0 GO:0033013 5 tetrapyrrole metabolic process 14 16 1 0 0 1 0 0 69 16 2462 0.64355 1.0 1.0 0.0 0 0 0 0 0 GO:0033014 6 tetrapyrrole biosynthetic process 8 8 1 0 0 1 0 0 69 8 2470 0.8025 1.0 1.0 0.0 0 0 0 0 0 GO:0033032 8 regulation of myeloid cell apoptotic process 13 15 1 1 0 1 0 0 69 15 2463 0.66158 1.0 1.0 0.0 0 0 0 0 0 GO:0033033 9 negative regulation of myeloid cell apoptotic process 7 8 1 1 0 1 0 0 69 8 2470 0.8025 1.0 1.0 0.0 0 0 0 0 0 GO:0033135 9 regulation of peptidyl-serine phosphorylation 38 46 1 1 1 0 0 0 69 46 2432 0.27948 1.0 0.6354 0.0 0 0 0 0 0 GO:0033138 10 positive regulation of peptidyl-serine phosphorylation 26 34 1 1 1 0 0 0 69 34 2444 0.39064 1.0 1.0 0.0 0 0 0 0 0 GO:0033280 6 response to vitamin D 17 20 2 2 2 0 0 0 69 20 2458 0.57616 1.0 1.0 0.0 0 0 0 0 0 GO:0033688 6 regulation of osteoblast proliferation 10 11 1 1 1 0 0 0 69 11 2467 0.73881 1.0 1.0 0.0 0 0 0 0 0 GO:0033690 7 positive regulation of osteoblast proliferation 5 6 1 1 1 0 0 0 69 6 2472 0.84794 1.0 1.0 0.0 0 0 0 0 0 GO:0034196 7 acylglycerol transport 2 2 1 1 0 1 0 0 69 2 2476 0.94654 1.0 1.0 0.0 0 0 0 0 0 GO:0034197 8 triglyceride transport 2 2 1 1 0 1 0 0 69 2 2476 0.94654 1.0 1.0 0.0 0 0 0 0 0 GO:0034250 7 positive regulation of cellular amide metabolic process 35 39 1 1 1 0 0 0 69 39 2439 0.33983 1.0 0.62521 0.0 0 0 0 0 0 GO:0034391 9 regulation of smooth muscle cell apoptotic process 11 13 1 1 0 1 0 0 69 13 2465 0.69915 1.0 1.0 0.0 0 0 0 0 0 GO:0034392 10 negative regulation of smooth muscle cell apoptotic process 6 8 1 1 0 1 0 0 69 8 2470 0.8025 1.0 1.0 0.0 0 0 0 0 0 GO:0034405 4 response to fluid shear stress 18 20 2 2 1 0 0 0 69 20 2458 0.57616 1.0 1.0 0.0 0 0 0 0 0 GO:0034655 5 nucleobase-containing compound catabolic process 33 39 1 1 1 0 0 0 69 39 2439 0.33983 1.0 0.62521 0.0 0 0 0 0 0 GO:0034656 6 nucleobase-containing small molecule catabolic process 4 7 1 1 1 0 0 0 69 7 2471 0.82491 1.0 1.0 0.0 0 0 0 0 0 GO:0034769 7 basement membrane disassembly 3 3 1 0 1 0 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:0035437 7 maintenance of protein localization in endoplasmic reticulum 4 4 1 1 0 1 0 0 69 4 2474 0.8959 1.0 1.0 0.0 0 0 0 0 0 GO:0035633 7 maintenance of blood-brain barrier 3 3 1 1 1 0 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:0036314 5 response to sterol 18 18 1 1 0 1 0 0 69 18 2460 0.60894 1.0 1.0 0.0 0 0 0 0 0 GO:0036315 6 cellular response to sterol 9 9 1 1 0 1 0 0 69 9 2469 0.78069 1.0 1.0 0.0 0 0 0 0 0 GO:0036316 10 SREBP-SCAP complex retention in endoplasmic reticulum 1 1 1 1 0 1 0 0 69 1 2477 0.97291 1.0 1.0 0.0 0 0 0 0 0 GO:0042089 6 cytokine biosynthetic process 5 5 1 0 1 0 0 0 69 5 2473 0.87159 1.0 1.0 0.0 0 0 0 0 0 GO:0042107 5 cytokine metabolic process 5 5 1 0 1 0 0 0 69 5 2473 0.87159 1.0 1.0 0.0 0 0 0 0 0 GO:0042133 4 neurotransmitter metabolic process 31 35 1 1 1 0 0 0 69 35 2443 0.37991 1.0 1.0 0.0 0 0 0 0 0 GO:0042136 5 neurotransmitter biosynthetic process 14 17 1 1 1 0 0 0 69 17 2461 0.62601 1.0 1.0 0.0 0 0 0 0 0 GO:0042168 5 heme metabolic process 11 11 1 0 0 1 0 0 69 11 2467 0.73881 1.0 1.0 0.0 0 0 0 0 0 GO:0042177 7 negative regulation of protein catabolic process 37 38 1 1 0 1 0 0 69 38 2440 0.34944 1.0 0.62464 0.0 0 0 0 0 0 GO:0042219 6 cellular modified amino acid catabolic process 6 6 1 1 0 1 0 0 69 6 2472 0.84794 1.0 1.0 0.0 0 0 0 0 0 GO:0042222 6 interleukin-1 biosynthetic process 1 1 1 0 1 0 0 0 69 1 2477 0.97291 1.0 1.0 0.0 0 0 0 0 0 GO:0042303 3 molting cycle 1 1 1 1 1 0 0 0 69 1 2477 0.97291 1.0 1.0 0.0 0 0 0 0 0 GO:0042304 7 regulation of fatty acid biosynthetic process 23 24 2 2 1 1 0 0 69 24 2454 0.51572 1.0 1.0 0.0 0 0 0 0 0 GO:0042359 5 vitamin D metabolic process 3 3 1 1 1 0 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:0042363 6 fat-soluble vitamin catabolic process 4 4 1 1 1 0 0 0 69 4 2474 0.8959 1.0 1.0 0.0 0 0 0 0 0 GO:0042369 6 vitamin D catabolic process 1 1 1 1 1 0 0 0 69 1 2477 0.97291 1.0 1.0 0.0 0 0 0 0 0 GO:0042440 3 pigment metabolic process 14 19 1 0 0 1 0 0 69 19 2459 0.59232 1.0 1.0 0.0 0 0 0 0 0 GO:0042472 5 inner ear morphogenesis 13 13 1 1 0 1 0 0 69 13 2465 0.69915 1.0 1.0 0.0 0 0 0 0 0 GO:0042474 5 middle ear morphogenesis 4 4 1 1 0 1 0 0 69 4 2474 0.8959 1.0 1.0 0.0 0 0 0 0 0 GO:0042541 6 hemoglobin biosynthetic process 5 5 1 0 0 1 0 0 69 5 2473 0.87159 1.0 1.0 0.0 0 0 0 0 0 GO:0042633 4 hair cycle 1 1 1 1 1 0 0 0 69 1 2477 0.97291 1.0 1.0 0.0 0 0 0 0 0 GO:0043094 4 cellular metabolic compound salvage 7 9 1 1 0 1 0 0 69 9 2469 0.78069 1.0 1.0 0.0 0 0 0 0 0 GO:0043102 6 amino acid salvage 4 4 1 1 0 1 0 0 69 4 2474 0.8959 1.0 1.0 0.0 0 0 0 0 0 GO:0043280 9 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process 44 47 2 2 1 0 0 0 69 47 2431 0.27177 1.0 0.6376 0.0 0 0 0 0 0 GO:0043401 6 steroid hormone mediated signaling pathway 34 37 1 1 0 1 0 0 69 37 2441 0.35932 1.0 0.62434 0.0 0 0 0 0 0 GO:0043414 4 macromolecule methylation 28 34 1 1 0 1 0 0 69 34 2444 0.39064 1.0 1.0 0.0 0 0 0 0 0 GO:0043502 5 regulation of muscle adaptation 33 33 1 1 1 0 0 0 69 33 2445 0.40166 1.0 1.0 0.0 0 0 0 0 0 GO:0043535 7 regulation of blood vessel endothelial cell migration 35 37 1 1 1 0 0 0 69 37 2441 0.35932 1.0 0.62434 0.0 0 0 0 0 0 GO:0043536 8 positive regulation of blood vessel endothelial cell migration 22 23 1 1 1 0 0 0 69 23 2455 0.53022 1.0 1.0 0.0 0 0 0 0 0 GO:0044270 5 cellular nitrogen compound catabolic process 51 59 2 2 1 1 0 0 69 59 2419 0.1941 1.0 0.40753 0.0 0 0 0 0 0 GO:0044272 5 sulfur compound biosynthetic process 25 31 1 1 0 1 0 0 69 31 2447 0.42464 1.0 1.0 0.0 0 0 0 0 0 GO:0044319 5 wound healing, spreading of cells 13 13 1 1 1 0 0 0 69 13 2465 0.69915 1.0 1.0 0.0 0 0 0 0 0 GO:0044782 6 cilium organization 18 19 1 1 0 1 0 0 69 19 2459 0.59232 1.0 1.0 0.0 0 0 0 0 0 GO:0045132 4 meiotic chromosome segregation 8 8 1 1 1 0 0 0 69 8 2470 0.8025 1.0 1.0 0.0 0 0 0 0 0 GO:0045185 4 maintenance of protein location 25 26 1 1 0 1 0 0 69 26 2452 0.4879 1.0 1.0 0.0 0 0 0 0 0 GO:0045428 5 regulation of nitric oxide biosynthetic process 33 36 1 1 1 0 0 0 69 36 2442 0.36948 1.0 0.62432 0.0 0 0 0 0 0 GO:0045429 6 positive regulation of nitric oxide biosynthetic process 25 28 1 1 1 0 0 0 69 28 2450 0.46155 1.0 1.0 0.0 0 0 0 0 0 GO:0045600 7 positive regulation of fat cell differentiation 16 17 1 1 1 0 0 0 69 17 2461 0.62601 1.0 1.0 0.0 0 0 0 0 0 GO:0045667 6 regulation of osteoblast differentiation 33 34 1 1 1 0 0 0 69 34 2444 0.39064 1.0 1.0 0.0 0 0 0 0 0 GO:0045669 7 positive regulation of osteoblast differentiation 22 22 1 1 1 0 0 0 69 22 2456 0.54512 1.0 1.0 0.0 0 0 0 0 0 GO:0045717 8 negative regulation of fatty acid biosynthetic process 10 10 1 1 0 1 0 0 69 10 2468 0.75947 1.0 1.0 0.0 0 0 0 0 0 GO:0045723 8 positive regulation of fatty acid biosynthetic process 13 14 1 1 1 0 0 0 69 14 2464 0.68011 1.0 1.0 0.0 0 0 0 0 0 GO:0045766 7 positive regulation of angiogenesis 68 69 4 3 3 0 0 0 69 69 2409 0.14644 1.0 0.26121 0.0 0 0 0 0 0 GO:0045778 6 positive regulation of ossification 29 30 1 1 1 0 0 0 69 30 2448 0.43661 1.0 1.0 0.0 0 0 0 0 0 GO:0045922 7 negative regulation of fatty acid metabolic process 13 15 1 1 0 1 0 0 69 15 2463 0.66158 1.0 1.0 0.0 0 0 0 0 0 GO:0045923 7 positive regulation of fatty acid metabolic process 25 26 1 1 1 0 0 0 69 26 2452 0.4879 1.0 1.0 0.0 0 0 0 0 0 GO:0045932 6 negative regulation of muscle contraction 8 8 1 1 1 0 0 0 69 8 2470 0.8025 1.0 1.0 0.0 0 0 0 0 0 GO:0045933 6 positive regulation of muscle contraction 15 16 1 1 1 0 0 0 69 16 2462 0.64355 1.0 1.0 0.0 0 0 0 0 0 GO:0045939 7 negative regulation of steroid metabolic process 5 5 1 1 0 1 0 0 69 5 2473 0.87159 1.0 1.0 0.0 0 0 0 0 0 GO:0045986 7 negative regulation of smooth muscle contraction 6 6 1 1 1 0 0 0 69 6 2472 0.84794 1.0 1.0 0.0 0 0 0 0 0 GO:0045987 7 positive regulation of smooth muscle contraction 12 12 1 1 1 0 0 0 69 12 2466 0.71871 1.0 1.0 0.0 0 0 0 0 0 GO:0046104 8 thymidine metabolic process 1 1 1 1 1 0 0 0 69 1 2477 0.97291 1.0 1.0 0.0 0 0 0 0 0 GO:0046113 6 nucleobase catabolic process 5 6 1 1 1 0 0 0 69 6 2472 0.84794 1.0 1.0 0.0 0 0 0 0 0 GO:0046121 8 deoxyribonucleoside catabolic process 2 2 1 1 1 0 0 0 69 2 2476 0.94654 1.0 1.0 0.0 0 0 0 0 0 GO:0046125 7 pyrimidine deoxyribonucleoside metabolic process 2 2 1 1 1 0 0 0 69 2 2476 0.94654 1.0 1.0 0.0 0 0 0 0 0 GO:0046127 8 pyrimidine deoxyribonucleoside catabolic process 1 1 1 1 1 0 0 0 69 1 2477 0.97291 1.0 1.0 0.0 0 0 0 0 0 GO:0046135 7 pyrimidine nucleoside catabolic process 2 3 1 1 1 0 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:0046148 4 pigment biosynthetic process 8 10 1 0 0 1 0 0 69 10 2468 0.75947 1.0 1.0 0.0 0 0 0 0 0 GO:0046457 7 prostanoid biosynthetic process 5 7 1 1 1 0 0 0 69 7 2471 0.82491 1.0 1.0 0.0 0 0 0 0 0 GO:0046500 4 S-adenosylmethionine metabolic process 6 7 1 1 0 1 0 0 69 7 2471 0.82491 1.0 1.0 0.0 0 0 0 0 0 GO:0046501 6 protoporphyrinogen IX metabolic process 4 4 1 0 0 1 0 0 69 4 2474 0.8959 1.0 1.0 0.0 0 0 0 0 0 GO:0046697 4 decidualization 10 11 1 1 1 0 0 0 69 11 2467 0.73881 1.0 1.0 0.0 0 0 0 0 0 GO:0046700 5 heterocycle catabolic process 52 63 1 1 1 0 0 0 69 63 2415 0.17343 1.0 0.4158 0.0 0 0 0 0 0 GO:0047484 6 regulation of response to osmotic stress 5 5 1 1 1 0 0 0 69 5 2473 0.87159 1.0 1.0 0.0 0 0 0 0 0 GO:0048167 5 regulation of synaptic plasticity 59 62 1 1 1 0 0 0 69 62 2416 0.17839 1.0 0.41345 0.0 0 0 0 0 0 GO:0048598 4 embryonic morphogenesis 73 77 1 1 0 1 0 0 69 77 2401 0.11679 1.0 0.27036 0.0 0 0 0 0 0 GO:0048871 4 multicellular organismal homeostasis 34 36 1 1 0 1 0 0 69 36 2442 0.36948 1.0 0.62432 0.0 0 0 0 0 0 GO:0050720 7 interleukin-1 beta biosynthetic process 1 1 1 0 1 0 0 0 69 1 2477 0.97291 1.0 1.0 0.0 0 0 0 0 0 GO:0050729 7 positive regulation of inflammatory response 47 52 1 1 1 0 0 0 69 52 2426 0.23625 1.0 0.40129 0.0 0 0 0 0 0 GO:0050805 6 negative regulation of synaptic transmission 19 19 1 1 1 0 0 0 69 19 2459 0.59232 1.0 1.0 0.0 0 0 0 0 0 GO:0050820 6 positive regulation of coagulation 19 20 1 1 0 1 0 0 69 20 2458 0.57616 1.0 1.0 0.0 0 0 0 0 0 GO:0050873 6 brown fat cell differentiation 15 17 1 1 1 0 0 0 69 17 2461 0.62601 1.0 1.0 0.0 0 0 0 0 0 GO:0051004 7 regulation of lipoprotein lipase activity 8 8 1 1 0 1 0 0 69 8 2470 0.8025 1.0 1.0 0.0 0 0 0 0 0 GO:0051006 8 positive regulation of lipoprotein lipase activity 5 5 1 1 0 1 0 0 69 5 2473 0.87159 1.0 1.0 0.0 0 0 0 0 0 GO:0051055 7 negative regulation of lipid biosynthetic process 19 19 1 1 0 1 0 0 69 19 2459 0.59232 1.0 1.0 0.0 0 0 0 0 0 GO:0051188 5 cofactor biosynthetic process 48 53 1 0 0 1 0 0 69 53 2425 0.22972 1.0 0.40146 0.0 0 0 0 0 0 GO:0051255 4 spindle midzone assembly 3 4 1 1 1 0 0 0 69 4 2474 0.8959 1.0 1.0 0.0 0 0 0 0 0 GO:0051256 5 mitotic spindle midzone assembly 3 4 1 1 1 0 0 0 69 4 2474 0.8959 1.0 1.0 0.0 0 0 0 0 0 GO:0051315 5 attachment of mitotic spindle microtubules to kinetochore 3 3 1 1 1 0 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:0051382 7 kinetochore assembly 5 5 1 1 1 0 0 0 69 5 2473 0.87159 1.0 1.0 0.0 0 0 0 0 0 GO:0051383 7 kinetochore organization 9 9 2 2 2 0 0 0 69 9 2469 0.78069 1.0 1.0 0.0 0 0 0 0 0 GO:0051896 7 regulation of protein kinase B signaling 44 47 1 1 0 0 0 0 69 47 2431 0.27177 1.0 0.6376 0.0 0 0 0 0 0 GO:0051897 8 positive regulation of protein kinase B signaling 32 35 1 1 0 0 0 0 69 35 2443 0.37991 1.0 1.0 0.0 0 0 0 0 0 GO:0051917 6 regulation of fibrinolysis 8 8 1 1 0 1 0 0 69 8 2470 0.8025 1.0 1.0 0.0 0 0 0 0 0 GO:0051918 6 negative regulation of fibrinolysis 5 5 1 1 0 1 0 0 69 5 2473 0.87159 1.0 1.0 0.0 0 0 0 0 0 GO:0055008 6 cardiac muscle tissue morphogenesis 15 16 1 1 1 0 0 0 69 16 2462 0.64355 1.0 1.0 0.0 0 0 0 0 0 GO:0055010 7 ventricular cardiac muscle tissue morphogenesis 12 13 1 1 1 0 0 0 69 13 2465 0.69915 1.0 1.0 0.0 0 0 0 0 0 GO:0055094 4 response to lipoprotein particle 21 21 1 1 0 0 0 0 69 21 2457 0.56042 1.0 1.0 0.0 0 0 0 0 0 GO:0060021 4 roof of mouth development 16 16 1 1 0 1 0 0 69 16 2462 0.64355 1.0 1.0 0.0 0 0 0 0 0 GO:0060048 7 cardiac muscle contraction 23 23 1 1 1 0 0 0 69 23 2455 0.53022 1.0 1.0 0.0 0 0 0 0 0 GO:0060193 7 positive regulation of lipase activity 18 18 2 2 1 1 0 0 69 18 2460 0.60894 1.0 1.0 0.0 0 0 0 0 0 GO:0060249 5 anatomical structure homeostasis 62 66 1 1 1 0 0 0 69 66 2412 0.15937 1.0 0.26089 0.0 0 0 0 0 0 GO:0060263 5 regulation of respiratory burst 7 7 1 1 0 1 0 0 69 7 2471 0.82491 1.0 1.0 0.0 0 0 0 0 0 GO:0060268 6 negative regulation of respiratory burst 3 3 1 1 0 1 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:0060271 7 cilium assembly 15 16 1 1 0 1 0 0 69 16 2462 0.64355 1.0 1.0 0.0 0 0 0 0 0 GO:0060363 5 cranial suture morphogenesis 6 6 1 1 0 1 0 0 69 6 2472 0.84794 1.0 1.0 0.0 0 0 0 0 0 GO:0060411 4 cardiac septum morphogenesis 16 17 1 1 1 0 0 0 69 17 2461 0.62601 1.0 1.0 0.0 0 0 0 0 0 GO:0060413 5 atrial septum morphogenesis 2 2 1 1 1 0 0 0 69 2 2476 0.94654 1.0 1.0 0.0 0 0 0 0 0 GO:0060561 7 apoptotic process involved in morphogenesis 9 9 1 1 1 0 0 0 69 9 2469 0.78069 1.0 1.0 0.0 0 0 0 0 0 GO:0060591 5 chondroblast differentiation 1 1 1 1 1 0 0 0 69 1 2477 0.97291 1.0 1.0 0.0 0 0 0 0 0 GO:0060628 6 regulation of ER to Golgi vesicle-mediated transport 3 3 1 1 0 1 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:0060674 4 placenta blood vessel development 10 11 1 1 1 0 0 0 69 11 2467 0.73881 1.0 1.0 0.0 0 0 0 0 0 GO:0060710 4 chorio-allantoic fusion 4 4 1 1 1 0 0 0 69 4 2474 0.8959 1.0 1.0 0.0 0 0 0 0 0 GO:0060716 5 labyrinthine layer blood vessel development 7 8 1 1 1 0 0 0 69 8 2470 0.8025 1.0 1.0 0.0 0 0 0 0 0 GO:0061365 8 positive regulation of triglyceride lipase activity 5 5 1 1 0 1 0 0 69 5 2473 0.87159 1.0 1.0 0.0 0 0 0 0 0 GO:0070167 5 regulation of biomineral tissue development 22 25 1 1 1 0 0 0 69 25 2453 0.50162 1.0 1.0 0.0 0 0 0 0 0 GO:0070169 6 positive regulation of biomineral tissue development 13 14 1 1 1 0 0 0 69 14 2464 0.68011 1.0 1.0 0.0 0 0 0 0 0 GO:0070303 7 negative regulation of stress-activated protein kinase signaling cascade 7 7 1 1 0 1 0 0 69 7 2471 0.82491 1.0 1.0 0.0 0 0 0 0 0 GO:0070861 8 regulation of protein exit from endoplasmic reticulum 7 7 1 1 0 1 0 0 69 7 2471 0.82491 1.0 1.0 0.0 0 0 0 0 0 GO:0070862 8 negative regulation of protein exit from endoplasmic reticulum 3 3 1 1 0 1 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:0071260 5 cellular response to mechanical stimulus 54 54 1 1 1 0 0 0 69 54 2424 0.22336 1.0 0.40188 0.0 0 0 0 0 0 GO:0071265 8 L-methionine biosynthetic process 4 4 1 1 0 1 0 0 69 4 2474 0.8959 1.0 1.0 0.0 0 0 0 0 0 GO:0071267 7 L-methionine salvage 4 4 1 1 0 1 0 0 69 4 2474 0.8959 1.0 1.0 0.0 0 0 0 0 0 GO:0071284 7 cellular response to lead ion 4 4 1 1 1 0 0 0 69 4 2474 0.8959 1.0 1.0 0.0 0 0 0 0 0 GO:0071404 5 cellular response to low-density lipoprotein particle stimulus 17 17 1 1 0 0 0 0 69 17 2461 0.62601 1.0 1.0 0.0 0 0 0 0 0 GO:0071470 5 cellular response to osmotic stress 10 10 1 1 1 0 0 0 69 10 2468 0.75947 1.0 1.0 0.0 0 0 0 0 0 GO:0071471 6 cellular response to non-ionic osmotic stress 1 1 1 1 1 0 0 0 69 1 2477 0.97291 1.0 1.0 0.0 0 0 0 0 0 GO:0071498 5 cellular response to fluid shear stress 10 11 1 1 1 0 0 0 69 11 2467 0.73881 1.0 1.0 0.0 0 0 0 0 0 GO:0071634 6 regulation of transforming growth factor beta production 10 11 1 1 1 0 0 0 69 11 2467 0.73881 1.0 1.0 0.0 0 0 0 0 0 GO:0071636 7 positive regulation of transforming growth factor beta production 4 5 1 1 1 0 0 0 69 5 2473 0.87159 1.0 1.0 0.0 0 0 0 0 0 GO:0071711 7 basement membrane organization 12 13 1 0 1 0 0 0 69 13 2465 0.69915 1.0 1.0 0.0 0 0 0 0 0 GO:0072523 6 purine-containing compound catabolic process 5 8 1 1 1 0 0 0 69 8 2470 0.8025 1.0 1.0 0.0 0 0 0 0 0 GO:0072527 5 pyrimidine-containing compound metabolic process 15 17 1 1 1 0 0 0 69 17 2461 0.62601 1.0 1.0 0.0 0 0 0 0 0 GO:0072529 6 pyrimidine-containing compound catabolic process 5 7 1 1 1 0 0 0 69 7 2471 0.82491 1.0 1.0 0.0 0 0 0 0 0 GO:0072595 6 maintenance of protein localization in organelle 10 10 1 1 0 1 0 0 69 10 2468 0.75947 1.0 1.0 0.0 0 0 0 0 0 GO:0090049 8 regulation of cell migration involved in sprouting angiogenesis 15 16 1 1 1 0 0 0 69 16 2462 0.64355 1.0 1.0 0.0 0 0 0 0 0 GO:0090050 9 positive regulation of cell migration involved in sprouting angiogenesis 9 10 1 1 1 0 0 0 69 10 2468 0.75947 1.0 1.0 0.0 0 0 0 0 0 GO:0090100 7 positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 30 31 1 1 1 0 0 0 69 31 2447 0.42464 1.0 1.0 0.0 0 0 0 0 0 GO:0090153 6 regulation of sphingolipid biosynthetic process 4 4 1 1 1 0 0 0 69 4 2474 0.8959 1.0 1.0 0.0 0 0 0 0 0 GO:0090154 7 positive regulation of sphingolipid biosynthetic process 3 3 1 1 1 0 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:0090257 6 regulation of muscle system process 64 65 2 2 2 0 0 0 69 65 2413 0.16393 1.0 0.42101 0.0 0 0 0 0 0 GO:0090270 6 regulation of fibroblast growth factor production 3 3 1 1 1 0 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:0090271 7 positive regulation of fibroblast growth factor production 2 2 1 1 1 0 0 0 69 2 2476 0.94654 1.0 1.0 0.0 0 0 0 0 0 GO:0090317 7 negative regulation of intracellular protein transport 13 15 1 1 0 1 0 0 69 15 2463 0.66158 1.0 1.0 0.0 0 0 0 0 0 GO:0090335 7 regulation of brown fat cell differentiation 3 3 1 1 1 0 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:0090336 8 positive regulation of brown fat cell differentiation 3 3 1 1 1 0 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:0090361 6 regulation of platelet-derived growth factor production 2 2 1 1 1 0 0 0 69 2 2476 0.94654 1.0 1.0 0.0 0 0 0 0 0 GO:0090362 7 positive regulation of platelet-derived growth factor production 1 1 1 1 1 0 0 0 69 1 2477 0.97291 1.0 1.0 0.0 0 0 0 0 0 GO:0097009 5 energy homeostasis 9 10 1 1 0 1 0 0 69 10 2468 0.75947 1.0 1.0 0.0 0 0 0 0 0 GO:0097094 4 craniofacial suture morphogenesis 6 6 1 1 0 1 0 0 69 6 2472 0.84794 1.0 1.0 0.0 0 0 0 0 0 GO:0097756 7 negative regulation of blood vessel diameter 12 13 1 1 1 0 0 0 69 13 2465 0.69915 1.0 1.0 0.0 0 0 0 0 0 GO:0106049 6 regulation of cellular response to osmotic stress 4 4 1 1 1 0 0 0 69 4 2474 0.8959 1.0 1.0 0.0 0 0 0 0 0 GO:0110149 4 regulation of biomineralization 22 25 1 1 1 0 0 0 69 25 2453 0.50162 1.0 1.0 0.0 0 0 0 0 0 GO:0110151 5 positive regulation of biomineralization 13 14 1 1 1 0 0 0 69 14 2464 0.68011 1.0 1.0 0.0 0 0 0 0 0 GO:0120031 7 plasma membrane bounded cell projection assembly 36 38 1 1 0 1 0 0 69 38 2440 0.34944 1.0 0.62464 0.0 0 0 0 0 0 GO:0150077 7 regulation of neuroinflammatory response 8 9 1 1 1 0 0 0 69 9 2469 0.78069 1.0 1.0 0.0 0 0 0 0 0 GO:1900048 5 positive regulation of hemostasis 17 18 1 1 0 1 0 0 69 18 2460 0.60894 1.0 1.0 0.0 0 0 0 0 0 GO:1901136 5 carbohydrate derivative catabolic process 18 22 2 2 2 0 0 0 69 22 2456 0.54512 1.0 1.0 0.0 0 0 0 0 0 GO:1901301 7 regulation of cargo loading into COPII-coated vesicle 1 1 1 1 0 1 0 0 69 1 2477 0.97291 1.0 1.0 0.0 0 0 0 0 0 GO:1901303 7 negative regulation of cargo loading into COPII-coated vesicle 1 1 1 1 0 1 0 0 69 1 2477 0.97291 1.0 1.0 0.0 0 0 0 0 0 GO:1901361 5 organic cyclic compound catabolic process 75 89 2 2 2 0 0 0 69 89 2389 0.083061 1.0 0.17393 0.0 0 0 0 0 0 GO:1901423 6 response to benzene 3 3 1 0 0 1 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:1901616 5 organic hydroxy compound catabolic process 18 19 1 1 1 0 0 0 69 19 2459 0.59232 1.0 1.0 0.0 0 0 0 0 0 GO:1901657 5 glycosyl compound metabolic process 17 22 1 1 1 0 0 0 69 22 2456 0.54512 1.0 1.0 0.0 0 0 0 0 0 GO:1901658 6 glycosyl compound catabolic process 5 8 1 1 1 0 0 0 69 8 2470 0.8025 1.0 1.0 0.0 0 0 0 0 0 GO:1901799 10 negative regulation of proteasomal protein catabolic process 10 10 1 1 0 1 0 0 69 10 2468 0.75947 1.0 1.0 0.0 0 0 0 0 0 GO:1902218 7 regulation of intrinsic apoptotic signaling pathway in response to osmotic stress 4 4 1 1 1 0 0 0 69 4 2474 0.8959 1.0 1.0 0.0 0 0 0 0 0 GO:1902219 8 negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress 3 3 1 1 1 0 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:1902742 6 apoptotic process involved in development 10 10 1 1 1 0 0 0 69 10 2468 0.75947 1.0 1.0 0.0 0 0 0 0 0 GO:1902850 6 microtubule cytoskeleton organization involved in mitosis 28 28 1 1 1 0 0 0 69 28 2450 0.46155 1.0 1.0 0.0 0 0 0 0 0 GO:1903051 9 negative regulation of proteolysis involved in cellular protein catabolic process 15 15 1 1 0 1 0 0 69 15 2463 0.66158 1.0 1.0 0.0 0 0 0 0 0 GO:1903363 8 negative regulation of cellular protein catabolic process 17 17 1 1 0 1 0 0 69 17 2461 0.62601 1.0 1.0 0.0 0 0 0 0 0 GO:1903426 6 regulation of reactive oxygen species biosynthetic process 44 48 1 1 1 0 0 0 69 48 2430 0.26427 1.0 0.63996 0.0 0 0 0 0 0 GO:1903428 7 positive regulation of reactive oxygen species biosynthetic process 30 33 1 1 1 0 0 0 69 33 2445 0.40166 1.0 1.0 0.0 0 0 0 0 0 GO:1903510 7 mucopolysaccharide metabolic process 20 20 1 1 1 0 0 0 69 20 2458 0.57616 1.0 1.0 0.0 0 0 0 0 0 GO:1903556 7 negative regulation of tumor necrosis factor superfamily cytokine production 19 19 1 1 0 0 0 0 69 19 2459 0.59232 1.0 1.0 0.0 0 0 0 0 0 GO:1903670 7 regulation of sprouting angiogenesis 26 27 1 1 1 0 0 0 69 27 2451 0.47454 1.0 1.0 0.0 0 0 0 0 0 GO:1903672 8 positive regulation of sprouting angiogenesis 16 17 1 1 1 0 0 0 69 17 2461 0.62601 1.0 1.0 0.0 0 0 0 0 0 GO:1903828 6 negative regulation of cellular protein localization 29 31 1 1 0 1 0 0 69 31 2447 0.42464 1.0 1.0 0.0 0 0 0 0 0 GO:1904018 6 positive regulation of vasculature development 76 78 4 3 3 0 0 0 69 78 2400 0.11352 1.0 0.27227 0.0 0 0 0 0 0 GO:1904407 5 positive regulation of nitric oxide metabolic process 25 28 1 1 1 0 0 0 69 28 2450 0.46155 1.0 1.0 0.0 0 0 0 0 0 GO:1905038 6 regulation of membrane lipid metabolic process 4 4 1 1 1 0 0 0 69 4 2474 0.8959 1.0 1.0 0.0 0 0 0 0 0 GO:1990264 9 peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity 5 5 1 0 1 1 0 0 69 5 2473 0.87159 1.0 1.0 0.0 0 0 0 0 0 GO:1990776 6 response to angiotensin 20 20 1 1 1 0 0 0 69 20 2458 0.57616 1.0 1.0 0.0 0 0 0 0 0 GO:2000059 10 negative regulation of ubiquitin-dependent protein catabolic process 10 10 1 1 0 1 0 0 69 10 2468 0.75947 1.0 1.0 0.0 0 0 0 0 0 GO:2000303 7 regulation of ceramide biosynthetic process 4 4 1 1 1 0 0 0 69 4 2474 0.8959 1.0 1.0 0.0 0 0 0 0 0 GO:2000304 8 positive regulation of ceramide biosynthetic process 3 3 1 1 1 0 0 0 69 3 2475 0.92088 1.0 1.0 0.0 0 0 0 0 0 GO:2000638 8 regulation of SREBP signaling pathway 1 1 1 1 0 1 0 0 69 1 2477 0.97291 1.0 1.0 0.0 0 0 0 0 0 GO:2000639 9 negative regulation of SREBP signaling pathway 1 1 1 1 0 1 0 0 69 1 2477 0.97291 1.0 1.0 0.0 0 0 0 0 0 GO:2001056 9 positive regulation of cysteine-type endopeptidase activity 48 51 2 2 1 0 0 0 69 51 2427 0.24297 1.0 0.40139 0.0 0 0 0 0 0 GO:2001279 8 regulation of unsaturated fatty acid biosynthetic process 5 6 1 1 1 0 0 0 69 6 2472 0.84794 1.0 1.0 0.0 0 0 0 0 0 GO:2001280 9 positive regulation of unsaturated fatty acid biosynthetic process 5 6 1 1 1 0 0 0 69 6 2472 0.84794 1.0 1.0 0.0 0 0 0 0 0 GO:0042542 5 response to hydrogen peroxide 74 80 6 6 5 5 5 5 64 75 2403 0.9803 0.06328 0.06328 6.25 24516;24440;360504;361921;29680 jun;hbb;hba-a2;ect2;cyp11a1 JUN_8938;HBB_8782;HBA2_32600;ECT2_8523;CYP11A1_32785 61.746759999999995 57.7663 14.4142 35.479094417459436 54.91730531227088 32.816760201124794 44.226690000000005 38.6865 9.59235 27.791094589688242 37.71999930013997 23.86309854540033 119.20327999999999 109.049 30.0753 94.90356678216581 113.04919377457843 91.33660352664715 3.0 91.4283 57.7663;91.4283;101.406;14.4142;43.719 38.6865;54.7263;84.6435;9.59235;33.4848 109.049;277.036;115.953;30.0753;63.9031 3 2 3 360504;361921;29680 HBA2_32600;ECT2_8523;CYP11A1_32785 53.17973333333333 43.719 44.26084526094518 42.573550000000004 33.4848 38.34218057834609 69.97713333333333 63.9031 43.25985725847156 101.406;14.4142;43.719 84.6435;9.59235;33.4848 115.953;30.0753;63.9031 2 24516;24440 JUN_8938;HBB_8782 74.59729999999999 74.59729999999999 23.8026284683016 46.7064 46.7064 11.341851348875977 193.04250000000002 193.04250000000002 118.78474685118454 57.7663;91.4283 38.6865;54.7263 109.049;277.036 0 Exp 2,2(0.4);Linear,1(0.2);Poly 2,2(0.4) 1.7148384690083793 8.589013457298279 1.5230457782745361 1.7797720432281494 0.10958758495060297 1.7553097009658813 30.64796257615156 92.84555742384843 19.86672154470553 68.58665845529447 36.016635960211445 202.38992403978853 UP 0.6 0.4 0.0 GO:0051592 6 response to calcium ion 51 56 5 5 5 5 5 5 64 51 2427 0.99646 0.016514 0.016514 8.93 24516;24367;361921;58919;81639 jun;fgg;ect2;ccnd1;alox15 JUN_8938;FGG_8639;ECT2_8523;CCND1_8224;ALOX15_8036 59.85047999999999 57.7663 14.4142 39.60000736170388 59.855442028925445 39.630095040652314 41.151430000000005 38.6865 9.59235 28.645639910804924 43.54228809415275 30.687245598747282 126.85520000000001 109.049 30.0753 120.14110482634571 104.06120081637728 91.23217633514336 1.5 43.0159 57.7663;93.1824;14.4142;28.2655;105.624 38.6865;51.338;9.59235;22.3101;83.8302 109.049;327.378;30.0753;38.3337;129.44 3 2 3 361921;58919;81639 ECT2_8523;CCND1_8224;ALOX15_8036 49.43456666666666 28.2655 49.151845760493394 38.57755 22.3101 39.70248153809155 65.94966666666666 38.3337 55.13907065523805 14.4142;28.2655;105.624 9.59235;22.3101;83.8302 30.0753;38.3337;129.44 2 24516;24367 JUN_8938;FGG_8639 75.47435 75.47435 25.0429644731809 45.01225 45.01225 8.945961442181625 218.2135 218.2135 154.3819164296777 57.7663;93.1824 38.6865;51.338 109.049;327.378 0 Exp 2,2(0.4);Linear,1(0.2);Poly 2,2(0.4) 1.8177579881434716 9.17073655128479 1.5230457782745361 2.2675669193267822 0.27997437062120484 1.7797720432281494 25.13954311885732 94.56141688114268 16.042419544980003 66.26044045502 21.546878504814217 232.16352149518576 UP 0.6 0.4 0.0 GO:1903530 5 regulation of secretion by cell 205 222 5 5 5 5 5 5 64 217 2261 0.43382 0.73269 0.82961 2.25 78968;24367;299691;29657;25649 srebf1;fgg;cry1;arntl;apoa2 SREBF1_32750;FGG_8639;CRY1_8386;ARNTL_8086;APOA2_33095 52.01472000000001 38.2177 11.2357 33.76155856217244 53.10483707581861 27.362277083270108 31.116681999999997 27.1236 4.94421 19.767903106541688 32.935265205042896 16.498680421797612 137.22892000000002 73.8251 24.5771 124.43751583540629 124.97393126247593 94.56302896290076 11.2357;93.1824;37.2548;38.2177;80.183 4.94421;51.338;21.8798;27.1236;50.2978 24.5771;327.378;73.8251;63.2034;197.161 2 3 2 78968;25649 SREBF1_32750;APOA2_33095 45.70935 45.70935 48.75310337450326 27.621005 27.621005 32.06983104015439 110.86905 110.86905 122.03524601362099 11.2357;80.183 4.94421;50.2978 24.5771;197.161 3 24367;299691;29657 FGG_8639;CRY1_8386;ARNTL_8086 56.2183 38.2177 32.01546986551971 33.44713333333333 27.1236 15.714219426154559 154.80216666666666 73.8251 149.54938587551382 93.1824;37.2548;38.2177 51.338;21.8798;27.1236 327.378;73.8251;63.2034 0 Exp 2,2(0.4);Hill,1(0.2);Linear,1(0.2);Power,1(0.2) 2.50204949272517 13.49693763256073 1.8622472286224365 4.897102355957031 1.295256387263889 1.9712703227996826 22.421409131227797 81.6080308687722 13.78935095340827 48.444013046591735 28.154628211203388 246.3032117887966 DOWN 0.4 0.6 0.0 GO:0008654 5 phospholipid biosynthetic process 31 34 3 3 3 3 3 3 66 31 2447 0.9876 0.062612 0.062612 8.82 24450;25649;81639 hmgcs2;apoa2;alox15 HMGCS2_8812;APOA2_33095;ALOX15_8036 72.13516666666668 80.183 30.5985 38.154713058589934 73.6971476600074 36.05059932346268 52.90166666666667 50.2978 24.577 29.712295750637193 53.186217295597494 28.15054418975406 122.38886666666667 129.44 40.5656 78.5354613296015 131.1495208564558 78.69827274175628 0.5 55.390750000000004 30.5985;80.183;105.624 24.577;50.2978;83.8302 40.5656;197.161;129.44 3 0 3 24450;25649;81639 HMGCS2_8812;APOA2_33095;ALOX15_8036 72.13516666666668 80.183 38.154713058589934 52.90166666666667 50.2978 29.712295750637193 122.38886666666667 129.44 78.5354613296015 30.5985;80.183;105.624 24.577;50.2978;83.8302 40.5656;197.161;129.44 0 0 Exp 2,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 2.2395274851290976 7.0314284563064575 1.6914535760879517 3.3687045574188232 0.8985442584352104 1.9712703227996826 28.959044310416203 115.31128902291712 19.27903884491724 86.5242944884161 33.51762597709599 211.2601073562373 UP 1.0 0.0 0.0 GO:0009056 3 catabolic process 364 413 19 18 18 16 14 14 55 399 2079 0.86263 0.2176 0.32431 3.39 25044;29692;362282;287167;85430;24440;360504;316033;171142;29740;25086;499353;29657;25649 sds;pla2g2a;pck1;hba-a1;herpud1;hbb;hba-a2;glb1;ehhadh;eci1;cyp2e1;cyp2c24;arntl;apoa2 SDS_9798;PLA2G2A_32641;PCK1_9439;LOC287167_9118;HERPUD1_8795;HBB_8782;HBA2_32600;GLB1_8712;EHHADH_8534;ECI1_8520;CYP2E1_8421;CYP2C24_32875;ARNTL_8086;APOA2_33095 57.324676428571514 59.3162 1.16694E-12 36.54075001803728 56.11177591696692 32.94731870061863 38.54893785714294 40.68855 1.16694E-12 26.18669928711249 36.47272045581702 21.3223026221416 99.87756428571437 99.9497 1.16694E-12 72.69032096049223 105.21185440421813 74.41664900732552 64.7394;1.16694E-12;5.51457;105.203;53.893;91.4283;101.406;65.9159;32.6956;103.231;49.5529;10.5651;38.2177;80.183 43.4259;1.16694E-12;1.34064;82.0435;37.9512;54.7263;84.6435;47.8573;25.6436;49.9975;26.9979;7.63639;27.1236;50.2978 126.828;1.16694E-12;39.6721;130.247;92.6554;277.036;115.953;114.587;45.0542;107.244;71.5977;17.0471;63.2034;197.161 9 5 9 362282;287167;85430;360504;316033;171142;29740;25086;25649 PCK1_9439;LOC287167_9118;HERPUD1_8795;HBA2_32600;GLB1_8712;EHHADH_8534;ECI1_8520;CYP2E1_8421;APOA2_33095 66.39944111111112 65.9159 34.57074781888167 45.19699333333333 47.8573 26.59712320895627 101.57459999999999 107.244 47.92143467184075 5.51457;105.203;53.893;101.406;65.9159;32.6956;103.231;49.5529;80.183 1.34064;82.0435;37.9512;84.6435;47.8573;25.6436;49.9975;26.9979;50.2978 39.6721;130.247;92.6554;115.953;114.587;45.0542;107.244;71.5977;197.161 5 25044;29692;24440;499353;29657 SDS_9798;PLA2G2A_32641;HBB_8782;CYP2C24_32875;ARNTL_8086 40.99010000000023 38.2177 37.82061737498445 26.582438000000234 27.1236 23.138986481546773 96.82290000000023 63.2034 112.07831017632246 64.7394;1.16694E-12;91.4283;10.5651;38.2177 43.4259;1.16694E-12;54.7263;7.63639;27.1236 126.828;1.16694E-12;277.036;17.0471;63.2034 0 Exp 2,2(0.15);Exp 3,1(0.08);Hill,2(0.15);Linear,4(0.29);Poly 2,4(0.29);Power,1(0.08) 2.0421318565301467 29.92924189567566 1.5270863771438599 4.897102355957031 0.8329143339066433 1.9446134567260742 38.18346101731662 76.4658918398264 24.831505901943622 52.26636981234227 61.800045594083144 137.9550829773456 UP 0.6428571428571429 0.35714285714285715 0.0 GO:0000819 5 sister chromatid segregation 14 14 2 2 2 2 2 2 67 12 2466 0.99441 0.053364 0.053364 14.29 360243;303575 top2a;kif18b TOP2A_10059;KIF18B_32882 8.757950000000001 8.757950000000001 3.6768 7.18583124245205 7.2719152579365085 6.87164988454451 5.2182900000000005 5.2182900000000005 1.12034 5.795376467926824 4.019802242063492 5.541989046646758 19.72205 19.72205 11.7489 11.275736864835045 17.39022001984127 10.782735262087533 0.0 3.6768 0.5 8.757950000000001 13.8391;3.6768 9.31624;1.12034 27.6952;11.7489 2 0 2 360243;303575 TOP2A_10059;KIF18B_32882 8.757950000000001 8.757950000000001 7.18583124245205 5.2182900000000005 5.2182900000000005 5.795376467926824 19.72205 19.72205 11.275736864835045 13.8391;3.6768 9.31624;1.12034 27.6952;11.7489 0 0 Exp 4,1(0.5);Poly 2,1(0.5) 1.8816393976483556 3.763364553451538 1.8689792156219482 1.8943853378295898 0.017964841296677515 1.881682276725769 -1.2011039999999973 18.717004 -2.8136919999999987 13.250271999999999 4.094676 35.349424 UP 1.0 0.0 0.0 GO:0009611 4 response to wounding 115 120 9 9 8 8 8 8 61 112 2366 0.99562 0.01436 0.01436 6.67 338475;24587;100911740;24516;170568;84032;24770;81639 nrep;nefh;mrln;jun;dmbt1;col3a1;ccl2;alox15 NREP_9364;NEFH_33218;LOC100911740_32571;JUN_8938;DMBT1_32993;COL3A1_8354;CCL2_8218;ALOX15_8036 64.275375 60.94355 21.7434 27.501300982771706 66.13352024773982 29.774739535312975 42.218875 39.4238 12.6557 20.662133625738107 43.44774139661854 23.941331353553462 153.6835625 131.1455 53.5645 77.29162562355157 158.5248147675238 75.34248528686251 5.0 79.3182 36.861;79.3182;91.003;57.7663;21.7434;57.8774;64.0097;105.624 28.0333;39.4261;54.5666;38.6865;12.6557;39.4215;41.1311;83.8302 53.5645;264.141;273.335;109.049;160.485;106.603;132.851;129.44 2 6 2 170568;81639 DMBT1_32993;ALOX15_8036 63.6837 63.6837 59.3125410699963 48.24295 48.24295 50.327971597561934 144.9625 144.9625 21.952130021936394 21.7434;105.624 12.6557;83.8302 160.485;129.44 6 338475;24587;100911740;24516;84032;24770 NREP_9364;NEFH_33218;LOC100911740_32571;JUN_8938;COL3A1_8354;CCL2_8218 64.47259999999999 60.94355 18.84324715764248 40.21085 39.4238 8.471005737632371 156.59058333333334 120.95 90.70088560230084 36.861;79.3182;91.003;57.7663;57.8774;64.0097 28.0333;39.4261;54.5666;38.6865;39.4215;41.1311 53.5645;264.141;273.335;109.049;106.603;132.851 0 Exp 2,4(0.5);Linear,2(0.25);Poly 2,2(0.25) 1.6465433104002594 13.194245457649231 1.5230457782745361 1.8159936666488647 0.10239426104196822 1.623603641986847 45.21794571195726 83.33280428804272 27.90074689546884 56.53700310453115 100.1231985448017 207.24392645519828 DOWN 0.25 0.75 0.0 GO:0043066 8 negative regulation of apoptotic process 279 296 12 12 11 10 9 9 60 287 2191 0.7242 0.40987 0.70239 3.04 29142;360918;24516;85430;24367;114851;24770;282840;25612 vnn1;pf4;jun;herpud1;fgg;cdkn1a;ccl2;atf5;asns VNN1_10157;PF4_32963;JUN_8938;HERPUD1_8795;FGG_8639;CDKN1A_8271;CCL2_8218;ATF5_8097;ASNS_8091 70.4120111111111 64.0097 20.8684 27.25701131101161 70.9581764605987 24.157823948774443 45.254244444444446 41.1311 17.1194 15.94185925653836 48.1005983220541 16.906339496352174 136.9019888888889 109.875 26.5474 87.96288990629009 129.30018366157202 70.66827939569394 20.8684;105.82;57.7663;53.893;93.1824;54.5478;64.0097;97.9563;85.6642 17.1194;53.8521;38.6865;37.9512;51.338;38.2987;41.1311;75.2121;53.6991 26.5474;109.875;109.049;92.6554;327.378;94.4701;132.851;114.804;224.488 3 6 3 29142;85430;25612 VNN1_10157;HERPUD1_8795;ASNS_8091 53.4752 53.893 32.39992040175407 36.256566666666664 37.9512 18.348636178837207 114.5636 92.6554 100.77250221424497 20.8684;53.893;85.6642 17.1194;37.9512;53.6991 26.5474;92.6554;224.488 6 360918;24516;24367;114851;24770;282840 PF4_32963;JUN_8938;FGG_8639;CDKN1A_8271;CCL2_8218;ATF5_8097 78.88041666666668 78.59604999999999 22.597334236711774 49.753083333333336 46.23455 14.110182060684638 148.07118333333332 112.3395 88.70631242319608 105.82;57.7663;93.1824;54.5478;64.0097;97.9563 53.8521;38.6865;51.338;38.2987;41.1311;75.2121 109.875;109.049;327.378;94.4701;132.851;114.804 0 Exp 2,5(0.56);Exp 3,1(0.12);Linear,2(0.23);Poly 2,1(0.12) 1.814683964409175 16.647560477256775 1.5230457782745361 2.642244338989258 0.40508432751608664 1.6645443439483643 52.60409705458356 88.21992516763864 34.838896396839374 55.6695924920495 79.43290081677938 194.3710769609984 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0061402 9 positive regulation of transcription from RNA polymerase II promoter in response to acidic pH 2 2 1 1 1 1 1 1 68 1 2477 0.99928 0.053458 0.053458 50.0 362282 pck1 PCK1_9439 5.51457 5.51457 5.51457 5.51457 1.34064 1.34064 1.34064 1.34064 39.6721 39.6721 39.6721 39.6721 0.0 5.51457 0.0 5.51457 5.51457 1.34064 39.6721 1 0 1 362282 PCK1_9439 5.51457 5.51457 1.34064 1.34064 39.6721 39.6721 5.51457 1.34064 39.6721 0 0 Hill,1(1) 2.3449018001556396 2.3449018001556396 2.3449018001556396 2.3449018001556396 0.0 2.3449018001556396 5.51457 5.51457 1.34064 1.34064 39.6721 39.6721 UP 1.0 0.0 0.0 GO:0001933 9 negative regulation of protein phosphorylation 121 130 4 4 3 4 3 3 66 127 2351 0.52758 0.69424 1.0 2.31 24516;116663;114851 jun;dusp6;cdkn1a JUN_8938;DUSP6_8506;CDKN1A_8271 52.62063333333333 54.5478 45.5478 6.333120406508511 52.34239134316955 6.131847391606125 36.765566666666665 38.2987 33.3115 2.997587298701063 36.718810003342405 2.9793145377824146 91.75263333333334 94.4701 71.7388 18.80295787431684 90.55342075156376 17.88031402770226 57.7663;45.5478;54.5478 38.6865;33.3115;38.2987 109.049;71.7388;94.4701 0 3 0 3 24516;116663;114851 JUN_8938;DUSP6_8506;CDKN1A_8271 52.62063333333333 54.5478 6.333120406508511 36.765566666666665 38.2987 2.997587298701063 91.75263333333334 94.4701 18.80295787431684 57.7663;45.5478;54.5478 38.6865;33.3115;38.2987 109.049;71.7388;94.4701 0 Exp 2,1(0.34);Linear,2(0.67) 1.583989779577564 4.755239009857178 1.5230457782745361 1.6645443439483643 0.07234179394446755 1.5676488876342773 45.45403294117776 59.7872337254889 33.37347731237084 40.15765602096249 70.47508346434923 113.03018320231745 DOWN 0.0 1.0 0.0 GO:0006811 5 ion transport 243 256 7 7 7 6 6 6 63 250 2228 0.45009 0.70772 0.8407 2.34 24825;29503;24777;29692;287562;25649 tf;slc22a2;slc10a1;pla2g2a;ccl12;apoa2 TF_10003;SLC22A2_9845;SLC10A1_9832;PLA2G2A_32641;CCL12_8217;APOA2_33095 41.152236666666866 38.47045 1.16694E-12 35.55699301197512 42.5742314713509 32.71799360027092 25.55080833333353 25.28565 1.16694E-12 21.607225215570942 26.58452112555105 20.753529551741476 122.26858333333352 94.05109999999999 1.16694E-12 126.96682748646441 178.6402403260307 138.05361743779906 51.412;81.8219;7.96762;1.16694E-12;25.5289;80.183 36.6131;46.3605;6.07525;1.16694E-12;13.9582;50.2978 86.0232;102.079;11.4863;1.16694E-12;336.862;197.161 3 3 3 24825;29503;25649 TF_10003;SLC22A2_9845;APOA2_33095 71.13896666666666 80.183 17.10369576154037 44.4238 46.3605 7.0449172237862365 128.42106666666666 102.079 60.06938491788755 51.412;81.8219;80.183 36.6131;46.3605;50.2978 86.0232;102.079;197.161 3 24777;29692;287562 SLC10A1_9832;PLA2G2A_32641;CCL12_8217 11.165506666667056 7.96762 13.061433426393915 6.677816666667056 6.07525 6.9985821243181485 116.1161000000004 11.4863 191.2578051924414 7.96762;1.16694E-12;25.5289 6.07525;1.16694E-12;13.9582 11.4863;1.16694E-12;336.862 0 Hill,1(0.17);Linear,2(0.34);Poly 2,3(0.5) 1.9152042896971713 11.620649099349976 1.5314651727676392 2.4529356956481934 0.3191985075684774 1.9798146486282349 12.7007167087651 69.60375662456862 8.261427331721482 42.84018933494556 20.67396241007367 223.86320425659338 CONFLICT 0.5 0.5 0.0 GO:0010951 8 negative regulation of endopeptidase activity 84 91 3 3 3 2 2 2 67 89 2389 0.54903 0.71523 1.0 2.2 84386;85430 slpi;herpud1 SLPI_9890;HERPUD1_8795 55.20615 55.20615 53.893 1.8570745394302026 55.737580860950374 1.6982014971903852 38.64135 38.64135 37.9512 0.9760194900714516 38.92065320883745 0.8925208569361196 96.3817 96.3817 92.6554 5.269783997471378 97.88973093108889 4.818953081506522 56.5193;53.893 39.3315;37.9512 100.108;92.6554 1 1 1 85430 HERPUD1_8795 53.893 53.893 37.9512 37.9512 92.6554 92.6554 53.893 37.9512 92.6554 1 84386 SLPI_9890 56.5193 56.5193 39.3315 39.3315 100.108 100.108 56.5193 39.3315 100.108 0 Linear,2(1) 1.5544660118226887 3.1094229221343994 1.5270863771438599 1.5823365449905396 0.03906776834608216 1.5547114610671997 52.632376 57.779924 37.288656 39.994044 89.07815199999999 103.685248 CONFLICT 0.5 0.5 0.0 GO:0050865 5 regulation of cell activation 163 173 6 6 5 5 5 5 64 168 2310 0.67373 0.50904 0.80783 2.89 29142;29692;24367;114851;24770 vnn1;pla2g2a;fgg;cdkn1a;ccl2 VNN1_10157;PLA2G2A_32641;FGG_8639;CDKN1A_8271;CCL2_8218 46.52166000000023 54.5478 1.16694E-12 36.63956100129985 48.44862587427724 30.101070907315286 29.577440000000234 38.2987 1.16694E-12 20.69478874313489 32.08254568401725 17.70868280573485 116.24930000000022 94.4701 1.16694E-12 129.3112606980921 105.65629663261464 102.3174648068409 20.8684;1.16694E-12;93.1824;54.5478;64.0097 17.1194;1.16694E-12;51.338;38.2987;41.1311 26.5474;1.16694E-12;327.378;94.4701;132.851 1 4 1 29142 VNN1_10157 20.8684 20.8684 17.1194 17.1194 26.5474 26.5474 20.8684 17.1194 26.5474 4 29692;24367;114851;24770 PLA2G2A_32641;FGG_8639;CDKN1A_8271;CCL2_8218 52.93497500000029 59.27875 38.93249514945657 32.69195000000029 39.7149 22.502545587036177 138.6747750000003 113.66055 137.63183981647944 1.16694E-12;93.1824;54.5478;64.0097 1.16694E-12;51.338;38.2987;41.1311 1.16694E-12;327.378;94.4701;132.851 0 Exp 2,3(0.6);Hill,1(0.2);Linear,1(0.2) 1.9192523239778405 9.764009475708008 1.559963583946228 2.642244338989258 0.4230653245245315 1.9088982343673706 14.405668766654792 78.63765123334568 11.437657871418587 47.71722212858188 2.9029824825649655 229.5956175174355 DOWN 0.2 0.8 0.0 GO:0051276 6 chromosome organization 85 90 5 5 5 3 3 3 66 87 2391 0.77466 0.44373 0.73431 3.33 360243;293502;303575 top2a;kif22;kif18b TOP2A_10059;KIF22_8963;KIF18B_32882 10.251666666666667 13.2391 3.6768 5.70189913654506 9.579497773180822 5.864012747723225 6.485856666666667 9.02099 1.12034 4.649018172241675 5.953822039425651 4.798455425218789 21.62633333333333 25.4349 11.7489 8.6284416880068 20.501195071793624 8.746541184090272 13.8391;13.2391;3.6768 9.31624;9.02099;1.12034 27.6952;25.4349;11.7489 3 0 3 360243;293502;303575 TOP2A_10059;KIF22_8963;KIF18B_32882 10.251666666666667 13.2391 5.70189913654506 6.485856666666667 9.02099 4.649018172241675 21.62633333333333 25.4349 8.6284416880068 13.8391;13.2391;3.6768 9.31624;9.02099;1.12034 27.6952;25.4349;11.7489 0 0 Exp 4,1(0.34);Poly 2,2(0.67) 1.7888623183531374 5.380170702934265 1.616806149482727 1.8943853378295898 0.15345299613398927 1.8689792156219482 3.7993603839689474 16.703972949364385 1.2249973559727279 11.746715977360605 11.862332396068236 31.390334270598434 UP 1.0 0.0 0.0 GO:0071354 7 cellular response to interleukin-6 12 12 2 2 2 2 2 2 67 10 2468 0.99649 0.040069 0.040069 16.67 24367;24770 fgg;ccl2 FGG_8639;CCL2_8218 78.59604999999999 78.59604999999999 64.0097 20.628213995520863 76.78700358645564 20.468950016849462 46.23455 46.23455 41.1311 7.217368204892991 45.601603586455624 7.161645165753628 230.1145 230.1145 132.851 137.5513608238755 218.05156541775196 136.4893698535853 0.0 64.0097 0.5 78.59604999999999 93.1824;64.0097 51.338;41.1311 327.378;132.851 0 2 0 2 24367;24770 FGG_8639;CCL2_8218 78.59604999999999 78.59604999999999 20.628213995520863 46.23455 46.23455 7.217368204892991 230.1145 230.1145 137.5513608238755 93.1824;64.0097 51.338;41.1311 327.378;132.851 0 Exp 2,2(1) 1.7256337186878188 3.4688618183135986 1.559963583946228 1.9088982343673706 0.24673405750374733 1.7344309091567993 50.00680399999999 107.185296 36.231788 56.237311999999996 39.47804000000005 420.75095999999996 DOWN 0.0 1.0 0.0 GO:0015939 5 pantothenate metabolic process 1 1 1 1 1 1 1 1 68 0 2478 1.0 0.027091 0.027091 100.0 29142 vnn1 VNN1_10157 20.8684 20.8684 20.8684 20.8684 17.1194 17.1194 17.1194 17.1194 26.5474 26.5474 26.5474 26.5474 0.0 20.8684 0.0 20.8684 20.8684 17.1194 26.5474 1 0 1 29142 VNN1_10157 20.8684 20.8684 17.1194 17.1194 26.5474 26.5474 20.8684 17.1194 26.5474 0 0 Exp 2,1(1) 2.642244338989258 2.642244338989258 2.642244338989258 2.642244338989258 0.0 2.642244338989258 20.8684 20.8684 17.1194 17.1194 26.5474 26.5474 UP 1.0 0.0 0.0 GO:0043152 6 induction of bacterial agglutination 3 3 1 1 1 1 1 1 68 2 2476 0.99787 0.07912 0.07912 33.33 170568 dmbt1 DMBT1_32993 21.7434 21.7434 21.7434 21.7434 12.6557 12.6557 12.6557 12.6557 160.485 160.485 160.485 160.485 0.0 21.7434 0.0 21.7434 21.7434 12.6557 160.485 1 0 1 170568 DMBT1_32993 21.7434 21.7434 12.6557 12.6557 160.485 160.485 21.7434 12.6557 160.485 0 0 Poly 2,1(1) 1.5998332500457764 1.5998332500457764 1.5998332500457764 1.5998332500457764 0.0 1.5998332500457764 21.7434 21.7434 12.6557 12.6557 160.485 160.485 UP 1.0 0.0 0.0 GO:0050776 5 regulation of immune response 176 199 5 5 5 5 5 5 64 194 2284 0.54419 0.63737 1.0 2.51 314654;84032;25649;29339;81639 myo1f;col3a1;apoa2;apcs;alox15 MYO1F_32715;COL3A1_8354;APOA2_33095;APCS_8057;ALOX15_8036 87.5192 91.9576 57.8774 19.289263634986156 92.75332204631967 14.435808327104926 58.63606 58.4986 39.4215 16.429548048500926 61.42589210573126 15.061169650945175 187.90640000000002 129.44 106.603 121.67509278319864 220.53522053434838 126.35088134181 91.9576;57.8774;80.183;101.954;105.624 61.1322;39.4215;50.2978;58.4986;83.8302 110.707;106.603;197.161;395.621;129.44 3 2 3 314654;25649;81639 MYO1F_32715;APOA2_33095;ALOX15_8036 92.58819999999999 91.9576 12.73221750206942 65.08673333333333 61.1322 17.112399389136932 145.76933333333332 129.44 45.481412404776215 91.9576;80.183;105.624 61.1322;50.2978;83.8302 110.707;197.161;129.44 2 84032;29339 COL3A1_8354;APCS_8057 79.9157 79.9157 31.166862751646956 48.96005 48.96005 13.489546775373896 251.112 251.112 204.3665876849736 57.8774;101.954 39.4215;58.4986 106.603;395.621 0 Exp 2,1(0.2);Linear,2(0.4);Poly 2,2(0.4) 1.6868491206546905 8.46305787563324 1.5863633155822754 1.9712703227996826 0.16141367739990492 1.6244933605194092 70.61141494829243 104.42698505170756 44.23492617978956 73.03719382021043 81.25347877632412 294.55932122367585 UP 0.6 0.4 0.0 GO:0000281 5 mitotic cytokinesis 13 16 3 3 3 2 2 2 67 14 2464 0.99172 0.067982 0.067982 12.5 361921;306575 ect2;ckap2 ECT2_8523;CKAP2_8324 13.268 13.268 12.1218 1.6209715851920259 13.782768372627945 1.4483010478087577 9.031395 9.031395 8.47044 0.7933101688810037 9.2833247613571 0.7088044968361552 25.7278 25.7278 21.3803 6.148293462417026 27.680299999999995 5.4933596277688075 0.0 12.1218 0.5 13.268 14.4142;12.1218 9.59235;8.47044 30.0753;21.3803 2 0 2 361921;306575 ECT2_8523;CKAP2_8324 13.268 13.268 1.6209715851920259 9.031395 9.031395 0.7933101688810037 25.7278 25.7278 6.148293462417026 14.4142;12.1218 9.59235;8.47044 30.0753;21.3803 0 0 Poly 2,2(1) 1.9712398429683635 3.9630777835845947 1.7797720432281494 2.1833057403564453 0.28534141367669646 1.9815388917922974 11.021448000000003 15.514551999999998 7.9319232 10.1308668 17.206699999999998 34.2489 UP 1.0 0.0 0.0 GO:0035690 5 cellular response to drug 160 174 7 7 6 5 5 5 64 169 2309 0.6688 0.5143 0.80869 2.87 24777;362282;79438;361921;24770 slc10a1;pck1;igfals;ect2;ccl2 SLC10A1_9832;PCK1_9439;IGFALS_8880;ECT2_8523;CCL2_8218 32.454477999999995 14.4142 5.51457 31.9525224783071 39.52121285508943 32.771048618384334 20.837048000000003 9.59235 1.34064 21.04636906893372 25.806498255430157 21.311269555083836 72.57614 39.6721 11.4863 63.37091526617711 83.97642921635433 68.37601697336513 7.96762;5.51457;70.3663;14.4142;64.0097 6.07525;1.34064;46.0459;9.59235;41.1311 11.4863;39.6721;148.796;30.0753;132.851 2 3 2 362282;361921 PCK1_9439;ECT2_8523 9.964385 9.964385 6.292988723051229 5.466495 5.466495 5.834840097384847 34.8737 34.8737 6.78596235769107 5.51457;14.4142 1.34064;9.59235 39.6721;30.0753 3 24777;79438;24770 SLC10A1_9832;IGFALS_8880;CCL2_8218 47.44787333333333 64.0097 34.33830795683056 31.084083333333336 41.1311 21.797250360557722 97.71109999999999 132.851 75.09725599201346 7.96762;70.3663;64.0097 6.07525;46.0459;41.1311 11.4863;148.796;132.851 0 Exp 2,1(0.2);Hill,1(0.2);Linear,1(0.2);Poly 2,2(0.4) 1.8943431221640286 9.665151715278625 1.527578592300415 2.4529356956481934 0.4378920267134794 1.7797720432281494 4.446857172878794 60.462098827121196 2.3890921282675777 39.28500387173243 17.02908366203193 128.12319633796807 DOWN 0.4 0.6 0.0 GO:0070447 8 positive regulation of oligodendrocyte progenitor proliferation 2 2 1 1 1 1 1 1 68 1 2477 0.99928 0.053458 0.053458 50.0 24825 tf TF_10003 51.412 51.412 51.412 51.412 36.6131 36.6131 36.6131 36.6131 86.0232 86.0232 86.0232 86.0232 0.0 51.412 0.0 51.412 51.412 36.6131 86.0232 1 0 1 24825 TF_10003 51.412 51.412 36.6131 36.6131 86.0232 86.0232 51.412 36.6131 86.0232 0 0 Linear,1(1) 2.0048909187316895 2.0048909187316895 2.0048909187316895 2.0048909187316895 0.0 2.0048909187316895 51.412 51.412 36.6131 36.6131 86.0232 86.0232 UP 1.0 0.0 0.0 GO:0044087 5 regulation of cellular component biogenesis 211 228 3 3 3 2 2 2 67 226 2252 0.045084 0.98872 0.08511 0.88 361921;81639 ect2;alox15 ECT2_8523;ALOX15_8036 60.019099999999995 60.019099999999995 14.4142 64.49506809066877 72.56492971521719 62.00659740328884 46.711275 46.711275 9.59235 52.49408715570975 56.922627557771605 50.46866101050268 79.75765 79.75765 30.0753 70.26145318056693 93.42517921181322 67.5504929185085 14.4142;105.624 9.59235;83.8302 30.0753;129.44 2 0 2 361921;81639 ECT2_8523;ALOX15_8036 60.019099999999995 60.019099999999995 64.49506809066877 46.711275 46.711275 52.49408715570975 79.75765 79.75765 70.26145318056693 14.4142;105.624 9.59235;83.8302 30.0753;129.44 0 0 Poly 2,2(1) 1.735050946554485 3.471225619316101 1.6914535760879517 1.7797720432281494 0.0624505870188351 1.7356128096580505 -29.366504 149.404704 -26.041817999999992 119.464368 -17.619755999999995 177.135056 UP 1.0 0.0 0.0 GO:0003006 3 developmental process involved in reproduction 220 234 7 7 7 5 5 5 64 229 2249 0.38036 0.77487 0.83148 2.14 24587;29680;58919;289054;29657 nefh;cyp11a1;ccnd1;aspm;arntl NEFH_33218;CYP11A1_32785;CCND1_8224;ASPM_8092;ARNTL_8086 39.96878 38.2177 10.3235 25.40332987320756 45.654647167283905 26.579994299175926 25.96114 27.1236 7.4611 12.194706781345744 28.04218487904815 10.896395091818716 89.2887 63.2034 16.8623 99.67471321842366 113.03184827042789 112.40336433279924 79.3182;43.719;28.2655;10.3235;38.2177 39.4261;33.4848;22.3101;7.4611;27.1236 264.141;63.9031;38.3337;16.8623;63.2034 3 2 3 29680;58919;289054 CYP11A1_32785;CCND1_8224;ASPM_8092 27.435999999999996 28.2655 16.713195617535273 21.085333333333335 22.3101 13.055009784114805 39.6997 38.3337 23.550131276916495 43.719;28.2655;10.3235 33.4848;22.3101;7.4611 63.9031;38.3337;16.8623 2 24587;29657 NEFH_33218;ARNTL_8086 58.76795 58.76795 29.062442260157724 33.27485 33.27485 8.699181175547476 163.6722 163.6722 142.08433955535003 79.3182;38.2177 39.4261;27.1236 264.141;63.2034 0 Exp 2,2(0.4);Linear,1(0.2);Poly 2,1(0.2);Power,1(0.2) 2.2135981816956343 12.229824542999268 1.5452834367752075 4.897102355957031 1.395752670737982 1.7671042680740356 17.70177959907345 62.23578040092656 15.27200821512343 36.650271784876566 1.9199617174766814 176.6574382825233 UP 0.6 0.4 0.0 GO:0045737 9 positive regulation of cyclin-dependent protein serine/threonine kinase activity 17 17 2 2 2 2 2 2 67 15 2463 0.99014 0.075732 0.075732 11.76 498709;58919 cks2;ccnd1 CKS2_8325;CCND1_8224 21.3426 21.3426 14.4197 9.790459070952696 24.302437180678126 8.850526342978176 15.966849999999999 15.966849999999999 9.6236 8.970710179523131 18.678861901997212 8.109477419159075 33.71475 33.71475 29.0958 6.5321817339231805 35.689549570366935 5.905059823469715 0.0 14.4197 0.5 21.3426 14.4197;28.2655 9.6236;22.3101 29.0958;38.3337 2 0 2 498709;58919 CKS2_8325;CCND1_8224 21.3426 21.3426 9.790459070952696 15.966849999999999 15.966849999999999 8.970710179523131 33.71475 33.71475 6.5321817339231805 14.4197;28.2655 9.6236;22.3101 29.0958;38.3337 0 0 Linear,1(0.5);Poly 2,1(0.5) 1.8629314872342118 3.798068046569824 1.530501127243042 2.2675669193267822 0.5211842197630466 1.899034023284912 7.773716000000006 34.911483999999994 3.534080000000001 28.39962 24.661608 42.767892 UP 1.0 0.0 0.0 GO:0001934 9 positive regulation of protein phosphorylation 270 289 14 14 13 11 11 11 58 278 2200 0.91583 0.15181 0.24471 3.81 24825;29692;24516;24367;361921;498709;114851;58919;24770;287562;81639 tf;pla2g2a;jun;fgg;ect2;cks2;cdkn1a;ccnd1;ccl2;ccl12;alox15 TF_10003;PLA2G2A_32641;JUN_8938;FGG_8639;ECT2_8523;CKS2_8325;CDKN1A_8271;CCND1_8224;CCL2_8218;CCL12_8217;ALOX15_8036 46.28822727272738 51.412 1.16694E-12 33.45144644854944 47.53241352890397 31.343811760868547 31.398350000000107 36.6131 1.16694E-12 23.857060618577737 33.168088006759916 24.239830963143852 119.41619090909103 94.4701 1.16694E-12 113.85552577809686 135.14023494002464 116.80520323359343 51.412;1.16694E-12;57.7663;93.1824;14.4142;14.4197;54.5478;28.2655;64.0097;25.5289;105.624 36.6131;1.16694E-12;38.6865;51.338;9.59235;9.6236;38.2987;22.3101;41.1311;13.9582;83.8302 86.0232;1.16694E-12;109.049;327.378;30.0753;29.0958;94.4701;38.3337;132.851;336.862;129.44 5 6 5 24825;361921;498709;58919;81639 TF_10003;ECT2_8523;CKS2_8325;CCND1_8224;ALOX15_8036 42.82708 28.2655 38.22127880300448 32.39387000000001 22.3101 30.836564632178142 62.593599999999995 38.3337 44.117662383845776 51.412;14.4142;14.4197;28.2655;105.624 36.6131;9.59235;9.6236;22.3101;83.8302 86.0232;30.0753;29.0958;38.3337;129.44 6 29692;24516;24367;114851;24770;287562 PLA2G2A_32641;JUN_8938;FGG_8639;CDKN1A_8271;CCL2_8218;CCL12_8217 49.172516666666866 56.15705 32.36268106195226 30.568750000000193 38.492599999999996 19.385220261915673 166.7683500000002 120.95 135.82925970031243 1.16694E-12;57.7663;93.1824;54.5478;64.0097;25.5289 1.16694E-12;38.6865;51.338;38.2987;41.1311;13.9582 1.16694E-12;109.049;327.378;94.4701;132.851;336.862 0 Exp 2,3(0.28);Hill,1(0.1);Linear,3(0.28);Poly 2,4(0.37) 1.753372632675886 19.45046067237854 1.5230457782745361 2.2675669193267822 0.24625828369281508 1.6914535760879517 26.519685703051916 66.05676884240285 17.299728127430157 45.49697187257005 52.1318748857651 186.70050693241694 CONFLICT 0.45454545454545453 0.5454545454545454 0.0 GO:0031400 8 negative regulation of protein modification process 161 172 5 5 4 5 4 4 65 168 2310 0.49624 0.69677 1.0 2.33 24516;116663;299691;114851 jun;dusp6;cry1;cdkn1a JUN_8938;DUSP6_8506;CRY1_8386;CDKN1A_8271 48.779175 50.0478 37.2548 9.261001632068012 47.91249783796546 9.303694996912801 33.044125 35.805099999999996 21.8798 7.834977050966168 32.36190289058283 8.152679069417868 87.27074999999999 84.14760000000001 71.7388 17.77779315335107 85.6417898779007 16.677200433716326 57.7663;45.5478;37.2548;54.5478 38.6865;33.3115;21.8798;38.2987 109.049;71.7388;73.8251;94.4701 0 4 0 4 24516;116663;299691;114851 JUN_8938;DUSP6_8506;CRY1_8386;CDKN1A_8271 48.779175 50.0478 9.261001632068012 33.044125 35.805099999999996 7.834977050966168 87.27074999999999 84.14760000000001 17.77779315335107 57.7663;45.5478;37.2548;54.5478 38.6865;33.3115;21.8798;38.2987 109.049;71.7388;73.8251;94.4701 0 Exp 2,2(0.5);Linear,2(0.5) 1.6493909808871354 6.617486238479614 1.5230457782745361 1.8622472286224365 0.1506464536440003 1.6160966157913208 39.70339340057333 57.85495659942666 25.365847490053145 40.72240250994685 69.84851270971603 104.69298729028398 DOWN 0.0 1.0 0.0 GO:0007093 7 mitotic cell cycle checkpoint 35 38 4 4 4 4 4 4 65 34 2444 0.99684 0.018198 0.018198 10.53 360243;304477;114851;58919 top2a;kntc1;cdkn1a;ccnd1 TOP2A_10059;KNTC1_8976;CDKN1A_8271;CCND1_8224 26.1376975 21.0523 7.89839 20.781316176524808 29.679619401290537 22.793814127003007 18.439905 15.81317 3.83458 15.339566808071861 20.86660041411419 16.780076274034002 43.266725 33.01445 12.5679 35.7351861813512 48.64259153393777 40.274935211431355 0.5 10.868745 2.5 41.40665 13.8391;7.89839;54.5478;28.2655 9.31624;3.83458;38.2987;22.3101 27.6952;12.5679;94.4701;38.3337 3 1 3 360243;304477;58919 TOP2A_10059;KNTC1_8976;CCND1_8224 16.667663333333333 13.8391 10.474033145643245 11.820306666666667 9.31624 9.488886774587062 26.198933333333333 27.6952 12.947904188065856 13.8391;7.89839;28.2655 9.31624;3.83458;22.3101 27.6952;12.5679;38.3337 1 114851 CDKN1A_8271 54.5478 54.5478 38.2987 38.2987 94.4701 94.4701 54.5478 38.2987 94.4701 0 Exp 5,1(0.25);Linear,2(0.5);Poly 2,1(0.25) 1.8656910953524428 7.5209715366363525 1.6645443439483643 2.2675669193267822 0.2776421607037277 1.794430136680603 5.772007647005687 46.50338735299432 3.4071295280895715 33.47268047191042 8.24624254227583 78.28720745772418 UP 0.75 0.25 0.0 GO:1905179 7 negative regulation of cardiac muscle tissue regeneration 2 2 1 1 1 1 1 1 68 1 2477 0.99928 0.053458 0.053458 50.0 114851 cdkn1a CDKN1A_8271 54.5478 54.5478 54.5478 54.5478 38.2987 38.2987 38.2987 38.2987 94.4701 94.4701 94.4701 94.4701 0.0 54.5478 0.0 54.5478 54.5478 38.2987 94.4701 0 1 0 1 114851 CDKN1A_8271 54.5478 54.5478 38.2987 38.2987 94.4701 94.4701 54.5478 38.2987 94.4701 0 Linear,1(1) 1.6645443439483643 1.6645443439483643 1.6645443439483643 1.6645443439483643 0.0 1.6645443439483643 54.5478 54.5478 38.2987 38.2987 94.4701 94.4701 DOWN 0.0 1.0 0.0 GO:0051413 6 response to cortisone 1 1 1 1 1 1 1 1 68 0 2478 1.0 0.027091 0.027091 100.0 316033 glb1 GLB1_8712 65.9159 65.9159 65.9159 65.9159 47.8573 47.8573 47.8573 47.8573 114.587 114.587 114.587 114.58699999999999 0.0 65.9159 0.0 65.9159 65.9159 47.8573 114.587 1 0 1 316033 GLB1_8712 65.9159 65.9159 47.8573 47.8573 114.587 114.587 65.9159 47.8573 114.587 0 0 Exp 2,1(1) 2.145577907562256 2.145577907562256 2.145577907562256 2.145577907562256 0.0 2.145577907562256 65.9159 65.9159 47.8573 47.8573 114.587 114.587 UP 1.0 0.0 0.0 GO:0002763 8 positive regulation of myeloid leukocyte differentiation 25 28 2 2 2 2 2 2 67 26 2452 0.96157 0.17463 0.17463 7.14 360918;24516 pf4;jun PF4_32963;JUN_8938 81.79315 81.79315 57.7663 33.97909713110399 70.76084586220955 30.185353611769763 46.2693 46.2693 38.6865 10.723698600762708 42.78753872808806 9.526404808259366 109.462 109.462 109.049 0.5840702012598943 109.27236458757984 0.5188591530580713 0.5 81.79315 105.82;57.7663 53.8521;38.6865 109.875;109.049 0 2 0 2 360918;24516 PF4_32963;JUN_8938 81.79315 81.79315 33.97909713110399 46.2693 46.2693 10.723698600762708 109.462 109.462 0.5840702012598943 105.82;57.7663 53.8521;38.6865 109.875;109.049 0 Exp 2,1(0.5);Exp 3,1(0.5) 1.6739647803547297 3.3628841638565063 1.5230457782745361 1.8398383855819702 0.22400620085685366 1.6814420819282532 34.70052400000001 128.885776 31.407012 61.131588 108.65252000000001 110.27148 DOWN 0.0 1.0 0.0 GO:0071236 5 cellular response to antibiotic 73 82 3 3 2 2 2 2 67 80 2398 0.61532 0.65942 1.0 2.44 361921;29680 ect2;cyp11a1 ECT2_8523;CYP11A1_32785 29.0666 29.0666 14.4142 20.721622801315533 24.15486294595549 19.522687564570933 21.538575 21.538575 9.59235 16.894513414160528 17.533994454256444 15.91701142823472 46.9892 46.9892 30.0753 23.919866772622324 41.31936916283998 22.53588389604411 14.4142;43.719 9.59235;33.4848 30.0753;63.9031 2 0 2 361921;29680 ECT2_8523;CYP11A1_32785 29.0666 29.0666 20.721622801315533 21.538575 21.538575 16.894513414160528 46.9892 46.9892 23.919866772622324 14.4142;43.719 9.59235;33.4848 30.0753;63.9031 0 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.7662181933912977 3.5325396060943604 1.752767562866211 1.7797720432281494 0.01909505118634565 1.7662698030471802 0.34789600000000576 57.785304 -1.876025999999996 44.953176 13.837955999999991 80.140444 UP 1.0 0.0 0.0 GO:0001822 5 kidney development 48 53 2 2 2 2 2 2 67 51 2427 0.82826 0.42399 0.65371 3.77 24450;24306 hmgcs2;cyp4a2 HMGCS2_8812;CYP4A2_8425 45.082800000000006 45.082800000000006 30.5985 20.483893501480612 45.64181966720592 20.46863178141994 33.9972 33.9972 24.577 13.322174600267052 34.36077138895309 13.312248787123448 70.07820000000001 70.07820000000001 40.5656 41.737119180892186 71.2172349433788 41.70602254250008 30.5985;59.5671 24.577;43.4174 40.5656;99.5908 2 0 2 24450;24306 HMGCS2_8812;CYP4A2_8425 45.082800000000006 45.082800000000006 20.483893501480612 33.9972 33.9972 13.322174600267052 70.07820000000001 70.07820000000001 41.737119180892186 30.5985;59.5671 24.577;43.4174 40.5656;99.5908 0 0 Exp 2,2(1) 2.539946005160654 5.2837806940078735 1.9150761365890503 3.3687045574188232 1.0278705136942248 2.6418903470039368 16.693572000000003 73.47202800000001 15.533608000000001 52.460792 12.233504000000018 127.92289600000001 UP 1.0 0.0 0.0 GO:0009968 6 negative regulation of signal transduction 284 297 10 10 8 9 7 7 62 290 2188 0.4356 0.71093 0.84955 2.36 29142;360918;85430;24367;116663;299691;29657 vnn1;pf4;herpud1;fgg;dusp6;cry1;arntl VNN1_10157;PF4_32963;HERPUD1_8795;FGG_8639;DUSP6_8506;CRY1_8386;ARNTL_8086 56.39772857142857 45.5478 20.8684 31.30219886412211 47.761732819977915 22.89597908815308 34.65365714285714 33.3115 17.1194 14.065004087196593 30.73576642532826 11.058801192139034 109.3175857142857 73.8251 26.5474 99.56370395139703 88.91994702724261 71.51217186591438 20.8684;105.82;53.893;93.1824;45.5478;37.2548;38.2177 17.1194;53.8521;37.9512;51.338;33.3115;21.8798;27.1236 26.5474;109.875;92.6554;327.378;71.7388;73.8251;63.2034 2 5 2 29142;85430 VNN1_10157;HERPUD1_8795 37.380700000000004 37.380700000000004 23.35191860597325 27.5353 27.5353 14.730307044321922 59.6014 59.6014 46.7454150906803 20.8684;53.893 17.1194;37.9512 26.5474;92.6554 5 360918;24367;116663;299691;29657 PF4_32963;FGG_8639;DUSP6_8506;CRY1_8386;ARNTL_8086 64.00453999999999 45.5478 32.86731342790281 37.501 33.3115 14.388235390936583 129.20406 73.8251 112.21819760358832 105.82;93.1824;45.5478;37.2548;38.2177 53.8521;51.338;33.3115;21.8798;27.1236 109.875;327.378;71.7388;73.8251;63.2034 0 Exp 2,3(0.43);Exp 3,1(0.15);Linear,2(0.29);Power,1(0.15) 2.1355894361969967 16.245065808296204 1.5270863771438599 4.897102355957031 1.193673318513782 1.8622472286224365 33.208735139921004 79.58672200293614 24.234156301784957 45.07315798392933 35.559761640406194 183.0754097881652 DOWN 0.2857142857142857 0.7142857142857143 0.0 GO:1902750 9 negative regulation of cell cycle G2/M phase transition 15 16 2 2 2 2 2 2 67 14 2464 0.99172 0.067982 0.067982 12.5 114851;282840 cdkn1a;atf5 CDKN1A_8271;ATF5_8097 76.25205 76.25205 54.5478 30.694444711136256 75.37635511811023 30.669451463511184 56.7554 56.7554 38.2987 26.101715456651508 56.01073304645059 26.080461883114417 104.63705 104.63705 94.4701 14.378238577969157 104.22684710980894 14.366530958542548 0.0 54.5478 0.5 76.25205 54.5478;97.9563 38.2987;75.2121 94.4701;114.804 0 2 0 2 114851;282840 CDKN1A_8271;ATF5_8097 76.25205 76.25205 30.694444711136256 56.7554 56.7554 26.101715456651508 104.63705 104.63705 14.378238577969157 54.5478;97.9563 38.2987;75.2121 94.4701;114.804 0 Linear,1(0.5);Poly 2,1(0.5) 1.992886428878672 4.050540447235107 1.6645443439483643 2.385996103286743 0.5101434313271328 2.0252702236175537 33.71172000000001 118.79237999999998 20.58026799999999 92.93053200000001 84.709828 124.564272 DOWN 0.0 1.0 0.0 GO:0019219 6 regulation of nucleobase-containing compound metabolic process 550 589 21 21 19 20 18 18 51 571 1907 0.7726 0.32057 0.56305 3.06 360243;24825;78968;360918;362282;316351;114519;366960;290350;24516;24309;299691;498709;306575;114851;58919;282840;29657 top2a;tf;srebf1;pf4;pck1;npas2;nfil3;maff;loxl2;jun;dbp;cry1;cks2;ckap2;cdkn1a;ccnd1;atf5;arntl TOP2A_10059;TF_10003;SREBF1_32750;PF4_32963;PCK1_9439;NPAS2_9350;NFIL3_9304;MAFF_9172;LOXL2_9150;JUN_8938;DBP_8439;CRY1_8386;CKS2_8325;CKAP2_8324;CDKN1A_8271;CCND1_8224;ATF5_8097;ARNTL_8086 44.10697055555555 44.456450000000004 5.51457 28.485425100256304 50.466289736031044 24.42351898696095 29.64145166666667 31.4593 1.34064 19.01206934130008 34.75053207162455 17.769775036179368 70.65157222222223 68.51425 21.3803 36.054856222327544 81.64356715858685 32.37259874572688 13.8391;51.412;11.2357;105.82;5.51457;58.2312;33.1149;58.0695;65.4434;57.7663;50.6952;37.2548;14.4197;12.1218;54.5478;28.2655;97.9563;38.2177 9.31624;36.6131;4.94421;53.8521;1.34064;35.795;25.603;40.1293;43.7615;38.6865;40.5862;21.8798;9.6236;8.47044;38.2987;22.3101;75.2121;27.1236 27.6952;86.0232;24.5771;109.875;39.6721;99.4319;46.6318;104.733;129.393;109.049;59.5346;73.8251;29.0958;21.3803;94.4701;38.3337;114.804;63.2034 8 10 8 360243;24825;78968;362282;366960;498709;306575;58919 TOP2A_10059;TF_10003;SREBF1_32750;PCK1_9439;MAFF_9172;CKS2_8325;CKAP2_8324;CCND1_8224 24.35973375 14.1294 19.892798217473388 16.593453750000002 9.46992 14.751637196827572 46.4388 33.71475 31.246905883394504 13.8391;51.412;11.2357;5.51457;58.0695;14.4197;12.1218;28.2655 9.31624;36.6131;4.94421;1.34064;40.1293;9.6236;8.47044;22.3101 27.6952;86.0232;24.5771;39.6721;104.733;29.0958;21.3803;38.3337 10 360918;316351;114519;290350;24516;24309;299691;114851;282840;29657 PF4_32963;NPAS2_9350;NFIL3_9304;LOXL2_9150;JUN_8938;DBP_8439;CRY1_8386;CDKN1A_8271;ATF5_8097;ARNTL_8086 59.904759999999996 56.15705 24.514708016082473 40.07985 38.492599999999996 15.527466976028856 90.02179 96.951 27.532790964288797 105.82;58.2312;33.1149;65.4434;57.7663;50.6952;37.2548;54.5478;97.9563;38.2177 53.8521;35.795;25.603;43.7615;38.6865;40.5862;21.8798;38.2987;75.2121;27.1236 109.875;99.4319;46.6318;129.393;109.049;59.5346;73.8251;94.4701;114.804;63.2034 0 Exp 2,2(0.12);Exp 3,1(0.06);Hill,2(0.12);Linear,6(0.34);Poly 2,5(0.28);Power,2(0.12) 2.3521764948887625 46.209039092063904 1.5230457782745361 5.737884044647217 1.2615537341745864 2.0940983295440674 30.94737555001872 57.266565561092406 20.85832373832686 38.42457959500647 53.99507844693986 87.30806599750457 CONFLICT 0.4444444444444444 0.5555555555555556 0.0 GO:0051249 6 regulation of lymphocyte activation 121 128 5 5 4 4 4 4 65 124 2354 0.73576 0.46024 0.7763 3.12 29142;29692;114851;24770 vnn1;pla2g2a;cdkn1a;ccl2 VNN1_10157;PLA2G2A_32641;CDKN1A_8271;CCL2_8218 34.85647500000029 37.7081 1.16694E-12 29.71138333920418 42.45487593625517 26.27884661761415 24.13730000000029 27.709049999999998 1.16694E-12 19.332137837462465 29.50256265399958 17.44160988957212 63.467125000000294 60.50875 1.16694E-12 61.00942172787018 75.9484422923692 51.99759717589798 20.8684;1.16694E-12;54.5478;64.0097 17.1194;1.16694E-12;38.2987;41.1311 26.5474;1.16694E-12;94.4701;132.851 1 3 1 29142 VNN1_10157 20.8684 20.8684 17.1194 17.1194 26.5474 26.5474 20.8684 17.1194 26.5474 3 29692;114851;24770 PLA2G2A_32641;CDKN1A_8271;CCL2_8218 39.519166666667054 54.5478 34.550040353424876 26.47660000000039 38.2987 22.97310129499213 75.77370000000039 94.4701 68.37041450781113 1.16694E-12;54.5478;64.0097 1.16694E-12;38.2987;41.1311 1.16694E-12;94.4701;132.851 0 Exp 2,2(0.5);Hill,1(0.25);Linear,1(0.25) 1.9218496097912048 7.855111241340637 1.559963583946228 2.642244338989258 0.4876910432413351 1.8264516592025757 5.739319327580205 63.973630672420384 5.191804919287076 43.08279508071351 3.6778917066875323 123.25635829331306 DOWN 0.25 0.75 0.0 GO:0065003 6 protein-containing complex assembly 203 233 7 7 7 6 6 6 63 227 2251 0.55347 0.61532 1.0 2.58 25044;360918;24367;361921;25649;29339 sds;pf4;fgg;ect2;apoa2;apcs SDS_9798;PF4_32963;FGG_8639;ECT2_8523;APOA2_33095;APCS_8057 76.7155 86.68270000000001 14.4142 34.035614016086164 77.73877915174883 30.575719828015274 44.500791666666665 50.8179 9.59235 17.796027763420046 46.42899158289727 16.505953624311513 197.82304999999997 161.99450000000002 30.0753 139.15704556886442 221.18030711236574 139.28003841890092 64.7394;105.82;93.1824;14.4142;80.183;101.954 43.4259;53.8521;51.338;9.59235;50.2978;58.4986 126.828;109.875;327.378;30.0753;197.161;395.621 2 4 2 361921;25649 ECT2_8523;APOA2_33095 47.2986 47.2986 46.50556447050182 29.945075000000003 29.945075000000003 28.783099726249947 113.61815 113.61815 118.14743150930111 14.4142;80.183 9.59235;50.2978 30.0753;197.161 4 25044;360918;24367;29339 SDS_9798;PF4_32963;FGG_8639;APCS_8057 91.42395 97.56819999999999 18.558785553927397 51.778650000000006 52.59505 6.309239993586047 239.9255 227.103 143.2866655031095 64.7394;105.82;93.1824;101.954 43.4259;53.8521;51.338;58.4986 126.828;109.875;327.378;395.621 0 Exp 2,1(0.17);Exp 3,1(0.17);Linear,3(0.5);Poly 2,1(0.17) 1.836700263831925 11.042228937149048 1.6244933605194092 1.9712703227996826 0.1250006487203783 1.8743683099746704 49.48133677556806 103.94966322443193 30.261003760197873 58.74057957313547 86.4742231193981 309.17187688060187 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0006732 5 coenzyme metabolic process 61 67 3 3 2 3 2 2 67 65 2413 0.72807 0.54809 0.70303 2.99 29142;24450 vnn1;hmgcs2 VNN1_10157;HMGCS2_8812 25.73345 25.73345 20.8684 6.880219691623219 27.968005238540695 6.111542258450005 20.8482 20.8482 17.1194 5.273319531376822 22.560866791393828 4.684169489174534 33.5565 33.5565 26.5474 9.912364280029278 36.775834050514504 8.80492715258878 20.8684;30.5985 17.1194;24.577 26.5474;40.5656 2 0 2 29142;24450 VNN1_10157;HMGCS2_8812 25.73345 25.73345 6.880219691623219 20.8482 20.8482 5.273319531376822 33.5565 33.5565 9.912364280029278 20.8684;30.5985 17.1194;24.577 26.5474;40.5656 0 0 Exp 2,2(1) 2.9834444098335733 6.010948896408081 2.642244338989258 3.3687045574188232 0.5136849467138063 3.0054744482040405 16.197952 35.268948 13.539751999999996 28.156648 19.818664 47.294336 UP 1.0 0.0 0.0 GO:0042737 5 drug catabolic process 55 60 7 7 7 6 6 6 63 54 2424 0.99903 0.0050154 0.0050154 10.0 362282;287167;24440;360504;25086;499353 pck1;hba-a1;hbb;hba-a2;cyp2e1;cyp2c24 PCK1_9439;LOC287167_9118;HBB_8782;HBA2_32600;CYP2E1_8421;CYP2C24_32875 60.61164499999999 70.4906 5.51457 45.309766600499614 50.2335133829773 43.80823028769414 42.89803833333334 40.8621 1.34064 36.43672353917921 34.17094221780444 33.13399147497326 108.59215 93.77535 17.0471 93.16169174760086 96.12846232225893 100.55577887974536 2.0 49.5529 5.0 105.203 5.51457;105.203;91.4283;101.406;49.5529;10.5651 1.34064;82.0435;54.7263;84.6435;26.9979;7.63639 39.6721;130.247;277.036;115.953;71.5977;17.0471 4 2 4 362282;287167;360504;25086 PCK1_9439;LOC287167_9118;HBA2_32600;CYP2E1_8421 65.4191175 75.47945 47.32196349751237 48.756384999999995 54.5207 41.30214518822116 89.36745 93.77535 41.48622624313601 5.51457;105.203;101.406;49.5529 1.34064;82.0435;84.6435;26.9979 39.6721;130.247;115.953;71.5977 2 24440;499353 HBB_8782;CYP2C24_32875 50.9967 50.9967 57.17891706844403 31.181345 31.181345 33.297594686464215 147.04155 147.04155 183.83991422323118 91.4283;10.5651 54.7263;7.63639 277.036;17.0471 0 Hill,1(0.17);Linear,1(0.17);Poly 2,4(0.67) 1.9889324094527365 12.048236846923828 1.6757243871688843 2.3449018001556396 0.3028946285543143 1.9908429384231567 24.356280878297603 96.86700912170238 13.742587347183683 72.05348931948298 34.04727127034833 183.13702872965166 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0072594 6 establishment of protein localization to organelle 64 68 3 3 3 3 3 3 66 65 2413 0.88973 0.27939 0.43002 4.41 286918;114851;29657 mx2;cdkn1a;arntl MX2_9268;CDKN1A_8271;ARNTL_8086 41.47533333333333 38.2177 31.6605 11.786274072977182 41.46364692248157 12.119693981878791 29.67373333333333 27.1236 23.5989 7.674530280305983 29.700554193653506 7.871023677104192 68.15316666666666 63.2034 46.786 24.224336745168777 67.99107289909976 24.981199320832165 31.6605;54.5478;38.2177 23.5989;38.2987;27.1236 46.786;94.4701;63.2034 0 3 0 3 286918;114851;29657 MX2_9268;CDKN1A_8271;ARNTL_8086 41.47533333333333 38.2177 11.786274072977182 29.67373333333333 27.1236 7.674530280305983 68.15316666666666 63.2034 24.224336745168777 31.6605;54.5478;38.2177 23.5989;38.2987;27.1236 46.786;94.4701;63.2034 0 Exp 2,1(0.34);Linear,1(0.34);Power,1(0.34) 2.787296051550291 9.21817684173584 1.6645443439483643 4.897102355957031 1.6559806244295898 2.6565301418304443 28.137908656132254 54.812758010534424 20.989184771785695 38.35828189488097 40.74074907877054 95.5655842545628 DOWN 0.0 1.0 0.0 GO:0019752 6 carboxylic acid metabolic process 287 320 18 18 17 15 14 14 55 306 2172 0.97878 0.043936 0.063094 4.38 29142;25044;83792;287877;362282;81660;171142;29740;24306;25086;499353;29680;25612;81639 vnn1;sds;scd2;pycr1;pck1;gatm;ehhadh;eci1;cyp4a2;cyp2e1;cyp2c24;cyp11a1;asns;alox15 VNN1_10157;SDS_9798;SCD_9786;PYCR1_9631;PCK1_9439;GATM_32792;EHHADH_8534;ECI1_8520;CYP4A2_8425;CYP2E1_8421;CYP2C24_32875;CYP11A1_32785;ASNS_8091;ALOX15_8036 54.133919285714285 52.13255 5.51457 32.01816574550201 58.707103067131605 30.26227089891713 36.22865928571428 35.935199999999995 1.34064 21.237480803661352 40.29052639393331 20.959474615033788 93.44171428571428 83.26400000000001 17.0471 62.539009782447074 101.02014167990991 61.947475847480966 20.8684;64.7394;83.9984;54.7122;5.51457;37.423;32.6956;103.231;59.5671;49.5529;10.5651;43.719;85.6642;105.624 17.1194;43.4259;54.1928;38.3856;1.34064;28.03;25.6436;49.9975;43.4174;26.9979;7.63639;33.4848;53.6991;83.8302 26.5474;126.828;206.18;94.9303;39.6721;55.6613;45.0542;107.244;99.5908;71.5977;17.0471;63.9031;224.488;129.44 11 3 11 29142;83792;287877;362282;171142;29740;24306;25086;29680;25612;81639 VNN1_10157;SCD_9786;PYCR1_9631;PCK1_9439;EHHADH_8534;ECI1_8520;CYP4A2_8425;CYP2E1_8421;CYP11A1_32785;ASNS_8091;ALOX15_8036 58.64976090909091 54.7122 32.882858833191634 38.918994545454545 38.3856 22.016458817710166 100.78614545454546 94.9303 64.70948342322575 20.8684;83.9984;54.7122;5.51457;32.6956;103.231;59.5671;49.5529;43.719;85.6642;105.624 17.1194;54.1928;38.3856;1.34064;25.6436;49.9975;43.4174;26.9979;33.4848;53.6991;83.8302 26.5474;206.18;94.9303;39.6721;45.0542;107.244;99.5908;71.5977;63.9031;224.488;129.44 3 25044;81660;499353 SDS_9798;GATM_32792;CYP2C24_32875 37.575833333333335 37.423 27.087473371345165 26.364096666666665 28.03 17.952818217400672 66.51213333333334 55.6613 55.689019916167794 64.7394;37.423;10.5651 43.4259;28.03;7.63639 126.828;55.6613;17.0471 0 Exp 2,7(0.5);Exp 3,1(0.08);Hill,1(0.08);Linear,2(0.15);Poly 2,3(0.22) 1.9419230091222661 27.505590558052063 1.5959433317184448 2.642244338989258 0.31842531007254166 1.894513189792633 37.36177839354889 70.90606017787968 25.103786516145792 47.353532055282784 60.681777577751376 126.20165099367722 UP 0.7857142857142857 0.21428571428571427 0.0 GO:0048522 5 positive regulation of cellular process 1060 1140 44 44 39 38 35 35 34 1105 1373 0.87127 0.18717 0.32797 3.07 29142;360243;24825;78968;29692;360918;362282;316351;114519;314654;366960;290350;24516;85430;24440;360504;24367;361921;116663;170568;24309;299691;84032;498709;306575;114851;58919;24770;287562;282840;289054;25612;29657;25649;81639 vnn1;top2a;tf;srebf1;pla2g2a;pf4;pck1;npas2;nfil3;myo1f;maff;loxl2;jun;herpud1;hbb;hba-a2;fgg;ect2;dusp6;dmbt1;dbp;cry1;col3a1;cks2;ckap2;cdkn1a;ccnd1;ccl2;ccl12;atf5;aspm;asns;arntl;apoa2;alox15 VNN1_10157;TOP2A_10059;TF_10003;SREBF1_32750;PLA2G2A_32641;PF4_32963;PCK1_9439;NPAS2_9350;NFIL3_9304;MYO1F_32715;MAFF_9172;LOXL2_9150;JUN_8938;HERPUD1_8795;HBB_8782;HBA2_32600;FGG_8639;ECT2_8523;DUSP6_8506;DMBT1_32993;DBP_8439;CRY1_8386;COL3A1_8354;CKS2_8325;CKAP2_8324;CDKN1A_8271;CCND1_8224;CCL2_8218;CCL12_8217;ATF5_8097;ASPM_8092;ASNS_8091;ARNTL_8086;APOA2_33095;ALOX15_8036 50.216493428571454 51.412 1.16694E-12 32.33937955215031 53.154180118822325 29.17062099967389 33.8804365714286 36.6131 1.16694E-12 22.588816271850696 36.176554882055704 21.207702649756577 103.67347142857147 94.4701 1.16694E-12 83.18667934762415 117.55277739644514 84.46015353481233 20.8684;13.8391;51.412;11.2357;1.16694E-12;105.82;5.51457;58.2312;33.1149;91.9576;58.0695;65.4434;57.7663;53.893;91.4283;101.406;93.1824;14.4142;45.5478;21.7434;50.6952;37.2548;57.8774;14.4197;12.1218;54.5478;28.2655;64.0097;25.5289;97.9563;10.3235;85.6642;38.2177;80.183;105.624 17.1194;9.31624;36.6131;4.94421;1.16694E-12;53.8521;1.34064;35.795;25.603;61.1322;40.1293;43.7615;38.6865;37.9512;54.7263;84.6435;51.338;9.59235;33.3115;12.6557;40.5862;21.8798;39.4215;9.6236;8.47044;38.2987;22.3101;41.1311;13.9582;75.2121;7.4611;53.6991;27.1236;50.2978;83.8302 26.5474;27.6952;86.0232;24.5771;1.16694E-12;109.875;39.6721;99.4319;46.6318;110.707;104.733;129.393;109.049;92.6554;277.036;115.953;327.378;30.0753;71.7388;160.485;59.5346;73.8251;106.603;29.0958;21.3803;94.4701;38.3337;132.851;336.862;114.804;16.8623;224.488;63.2034;197.161;129.44 18 17 18 29142;360243;24825;78968;362282;314654;366960;85430;360504;361921;170568;498709;306575;58919;289054;25612;25649;81639 VNN1_10157;TOP2A_10059;TF_10003;SREBF1_32750;PCK1_9439;MYO1F_32715;MAFF_9172;HERPUD1_8795;HBA2_32600;ECT2_8523;DMBT1_32993;CKS2_8325;CKAP2_8324;CCND1_8224;ASPM_8092;ASNS_8091;APOA2_33095;ALOX15_8036 43.38639833333333 25.00445 35.500575614827014 30.618343333333332 19.71475 26.827523163979542 81.9936 62.84765 64.63983041462721 20.8684;13.8391;51.412;11.2357;5.51457;91.9576;58.0695;53.893;101.406;14.4142;21.7434;14.4197;12.1218;28.2655;10.3235;85.6642;80.183;105.624 17.1194;9.31624;36.6131;4.94421;1.34064;61.1322;40.1293;37.9512;84.6435;9.59235;12.6557;9.6236;8.47044;22.3101;7.4611;53.6991;50.2978;83.8302 26.5474;27.6952;86.0232;24.5771;39.6721;110.707;104.733;92.6554;115.953;30.0753;160.485;29.0958;21.3803;38.3337;16.8623;224.488;197.161;129.44 17 29692;360918;316351;114519;290350;24516;24440;24367;116663;24309;299691;84032;114851;24770;287562;282840;29657 PLA2G2A_32641;PF4_32963;NPAS2_9350;NFIL3_9304;LOXL2_9150;JUN_8938;HBB_8782;FGG_8639;DUSP6_8506;DBP_8439;CRY1_8386;COL3A1_8354;CDKN1A_8271;CCL2_8218;CCL12_8217;ATF5_8097;ARNTL_8086 57.44835882352948 57.7663 27.844051999889754 37.33441764705889 38.6865 17.173986184278487 126.62862941176478 106.603 95.79643196581456 1.16694E-12;105.82;58.2312;33.1149;65.4434;57.7663;91.4283;93.1824;45.5478;50.6952;37.2548;57.8774;54.5478;64.0097;25.5289;97.9563;38.2177 1.16694E-12;53.8521;35.795;25.603;43.7615;38.6865;54.7263;51.338;33.3115;40.5862;21.8798;39.4215;38.2987;41.1311;13.9582;75.2121;27.1236 1.16694E-12;109.875;99.4319;46.6318;129.393;109.049;277.036;327.378;71.7388;59.5346;73.8251;106.603;94.4701;132.851;336.862;114.804;63.2034 0 Exp 2,7(0.2);Exp 3,1(0.03);Hill,3(0.09);Linear,10(0.29);Poly 2,12(0.35);Power,2(0.06) 2.023083759216139 75.82752931118011 1.5230457782745361 5.737884044647217 1.0035792693993768 1.8216042518615723 39.502441852849614 60.93054500429331 26.39675117230594 41.36412197055127 76.11368564151795 131.23325721562497 CONFLICT 0.5142857142857142 0.4857142857142857 0.0 GO:0016525 7 negative regulation of angiogenesis 32 34 3 3 2 3 2 2 67 32 2446 0.93739 0.23454 0.23454 5.88 360918;24770 pf4;ccl2 PF4_32963;CCL2_8218 84.91485 84.91485 64.0097 29.564346653443845 81.36162846715328 29.134169398183097 47.491600000000005 47.491600000000005 41.1311 8.995105363474005 46.41051397288843 8.86422170886808 121.363 121.363 109.875 16.246485404542216 123.31560062565174 16.010090243137423 0.5 84.91485 105.82;64.0097 53.8521;41.1311 109.875;132.851 0 2 0 2 360918;24770 PF4_32963;CCL2_8218 84.91485 84.91485 29.564346653443845 47.491600000000005 47.491600000000005 8.995105363474005 121.363 121.363 16.246485404542216 105.82;64.0097 53.8521;41.1311 109.875;132.851 0 Exp 2,1(0.5);Exp 3,1(0.5) 1.6941313059660672 3.3998019695281982 1.559963583946228 1.8398383855819702 0.19790137011987313 1.6999009847640991 43.94075600000001 125.888944 35.02502000000001 59.95818 98.84652 143.87948 DOWN 0.0 1.0 0.0 GO:1901566 5 organonitrogen compound biosynthetic process 169 188 8 6 6 6 4 4 65 184 2294 0.41457 0.76242 0.81553 2.13 287877;81660;25612;25649 pycr1;gatm;asns;apoa2 PYCR1_9631;GATM_32792;ASNS_8091;APOA2_33095 64.4956 67.44760000000001 37.423 22.530310924322993 61.608606380529515 22.87020590792213 42.603125000000006 44.3417 28.03 11.725928164364325 41.02381702022693 11.929488072077275 143.06015000000002 146.04565 55.6613 80.64828613324644 133.11347972701856 80.03908051791294 54.7122;37.423;85.6642;80.183 38.3856;28.03;53.6991;50.2978 94.9303;55.6613;224.488;197.161 3 1 3 287877;25612;25649 PYCR1_9631;ASNS_8091;APOA2_33095 73.5198 80.183 16.516817238196946 47.46083333333333 50.2978 8.04127511426725 172.1931 197.161 68.29235996895996 54.7122;85.6642;80.183 38.3856;53.6991;50.2978 94.9303;224.488;197.161 1 81660 GATM_32792 37.423 37.423 28.03 28.03 55.6613 55.6613 37.423 28.03 55.6613 0 Exp 2,2(0.5);Linear,2(0.5) 1.8376222295496472 7.410675525665283 1.5959433317184448 2.1833407878875732 0.2747076470663727 1.8156957030296326 42.41589529416349 86.5753047058365 31.111715398922925 54.09453460107707 64.02482958941842 222.09547041058158 UP 0.75 0.25 0.0 GO:0071385 8 cellular response to glucocorticoid stimulus 47 51 4 4 4 4 4 4 65 47 2431 0.98873 0.04743 0.04743 7.84 362282;79438;24450;24770 pck1;igfals;hmgcs2;ccl2 PCK1_9439;IGFALS_8880;HMGCS2_8812;CCL2_8218 42.6222675 47.3041 5.51457 30.2693784043031 49.54695237562261 25.582511493688735 28.273660000000003 32.85405 1.34064 20.16778900001353 33.78038033870495 15.634673270891268 90.471175 86.70830000000001 39.6721 58.50625953761271 97.79412298271316 59.830410585824566 1.5 47.3041 5.51457;70.3663;30.5985;64.0097 1.34064;46.0459;24.577;41.1311 39.6721;148.796;40.5656;132.851 2 2 2 362282;24450 PCK1_9439;HMGCS2_8812 18.056535 18.056535 17.737017001808677 12.958820000000001 12.958820000000001 16.430587726091847 40.11885 40.11885 0.6317999089898727 5.51457;30.5985 1.34064;24.577 39.6721;40.5656 2 79438;24770 IGFALS_8880;CCL2_8218 67.18799999999999 67.18799999999999 4.49479496529079 43.5885 43.5885 3.475288408175687 140.8235 140.8235 11.274817626019253 70.3663;64.0097 46.0459;41.1311 148.796;132.851 0 Exp 2,2(0.5);Hill,1(0.25);Linear,1(0.25) 2.082938282388629 8.801148533821106 1.527578592300415 3.3687045574188232 0.8657681960442292 1.9524326920509338 12.958276663782947 72.28625833621703 8.509226779986744 48.038093220013266 33.13504065313954 147.80730934686045 CONFLICT 0.5 0.5 0.0 GO:0032870 5 cellular response to hormone stimulus 198 212 11 11 10 11 10 10 59 202 2276 0.975 0.056402 0.073427 4.72 24825;78968;362282;24587;24516;79438;24450;29680;24770;25612 tf;srebf1;pck1;nefh;jun;igfals;hmgcs2;cyp11a1;ccl2;asns TF_10003;SREBF1_32750;PCK1_9439;NEFH_33218;JUN_8938;IGFALS_8880;HMGCS2_8812;CYP11A1_32785;CCL2_8218;ASNS_8091 49.960447 54.589150000000004 5.51457 27.28926732043777 58.22388615656882 23.67266852919148 31.994844999999998 37.6498 1.34064 17.003168307156603 36.65164648738058 13.230342323396803 113.40661000000003 97.5361 24.5771 80.65229535902108 137.44914703773105 85.54767151622251 51.412;11.2357;5.51457;79.3182;57.7663;70.3663;30.5985;43.719;64.0097;85.6642 36.6131;4.94421;1.34064;39.4261;38.6865;46.0459;24.577;33.4848;41.1311;53.6991 86.0232;24.5771;39.6721;264.141;109.049;148.796;40.5656;63.9031;132.851;224.488 6 4 6 24825;78968;362282;24450;29680;25612 TF_10003;SREBF1_32750;PCK1_9439;HMGCS2_8812;CYP11A1_32785;ASNS_8091 38.023995 37.15875 29.36281434435313 25.776475000000005 29.030900000000003 19.945203634157007 79.87151666666666 52.234350000000006 74.06103090050574 51.412;11.2357;5.51457;30.5985;43.719;85.6642 36.6131;4.94421;1.34064;24.577;33.4848;53.6991 86.0232;24.5771;39.6721;40.5656;63.9031;224.488 4 24587;24516;79438;24770 NEFH_33218;JUN_8938;IGFALS_8880;CCL2_8218 67.86512499999999 67.18799999999999 9.206508054043548 41.3224 40.2786 3.3111916505492136 163.70925 140.8235 68.91762221848633 79.3182;57.7663;70.3663;64.0097 39.4261;38.6865;46.0459;41.1311 264.141;109.049;148.796;132.851 0 Exp 2,6(0.6);Hill,2(0.2);Linear,2(0.2) 1.9541087465194453 20.302319884300232 1.5230457782745361 3.3687045574188232 0.6360719076183086 1.7599359154701233 33.046383879682466 66.87451012031754 21.45617209919836 42.53351790080164 63.41779943639368 163.3954205636063 UP 0.6 0.4 0.0 GO:0055129 9 L-proline biosynthetic process 1 1 1 1 1 1 1 1 68 0 2478 1.0 0.027091 0.027091 100.0 287877 pycr1 PYCR1_9631 54.7122 54.7122 54.7122 54.7122 38.3856 38.3856 38.3856 38.3856 94.9303 94.9303 94.9303 94.93030000000002 0.0 54.7122 0.0 54.7122 54.7122 38.3856 94.9303 1 0 1 287877 PYCR1_9631 54.7122 54.7122 38.3856 38.3856 94.9303 94.9303 54.7122 38.3856 94.9303 0 0 Linear,1(1) 1.6601210832595825 1.6601210832595825 1.6601210832595825 1.6601210832595825 0.0 1.6601210832595825 54.7122 54.7122 38.3856 38.3856 94.9303 94.9303 UP 1.0 0.0 0.0 GO:0031103 7 axon regeneration 17 18 3 3 3 3 3 3 66 15 2463 0.99887 0.011601 0.011601 16.67 338475;24587;24516 nrep;nefh;jun NREP_9364;NEFH_33218;JUN_8938 57.98183333333333 57.7663 36.861 21.229420597918715 63.03435859617682 20.555977383002833 35.38196666666667 38.6865 28.0333 6.374866929852976 36.67416998805257 5.646062308210316 142.2515 109.049 53.5645 109.14403370203064 167.91823324372763 111.19912223737848 0.0 36.861 0.5 47.313649999999996 36.861;79.3182;57.7663 28.0333;39.4261;38.6865 53.5645;264.141;109.049 0 3 0 3 338475;24587;24516 NREP_9364;NEFH_33218;JUN_8938 57.98183333333333 57.7663 21.229420597918715 35.38196666666667 38.6865 6.374866929852976 142.2515 109.049 109.14403370203064 36.861;79.3182;57.7663 28.0333;39.4261;38.6865 53.5645;264.141;109.049 0 Exp 2,2(0.67);Linear,1(0.34) 1.642816728060169 4.937524080276489 1.5230457782745361 1.7671042680740356 0.12203646351651709 1.6473740339279175 33.958482407315 82.00518425935167 28.16812563618928 42.59580769714406 18.743399012914423 265.7596009870856 DOWN 0.0 1.0 0.0 GO:0071310 5 cellular response to organic substance 516 551 21 20 20 19 18 18 51 533 1945 0.85482 0.21952 0.37392 3.27 24825;78968;360918;362282;114519;24587;286918;24516;79438;24450;24367;29680;84032;58919;24770;287562;25612;81639 tf;srebf1;pf4;pck1;nfil3;nefh;mx2;jun;igfals;hmgcs2;fgg;cyp11a1;col3a1;ccnd1;ccl2;ccl12;asns;alox15 TF_10003;SREBF1_32750;PF4_32963;PCK1_9439;NFIL3_9304;NEFH_33218;MX2_9268;JUN_8938;IGFALS_8880;HMGCS2_8812;FGG_8639;CYP11A1_32785;COL3A1_8354;CCND1_8224;CCL2_8218;CCL12_8217;ASNS_8091;ALOX15_8036 54.48211500000001 54.589150000000004 5.51457 30.841231205774665 54.13834466567874 29.10159104595961 35.21446944444445 37.6498 1.34064 19.613621949563672 35.697392536897844 19.736895003650012 126.4430888888889 107.826 24.5771 98.83112733708288 142.54907646904167 107.31507270161612 51.412;11.2357;105.82;5.51457;33.1149;79.3182;31.6605;57.7663;70.3663;30.5985;93.1824;43.719;57.8774;28.2655;64.0097;25.5289;85.6642;105.624 36.6131;4.94421;53.8521;1.34064;25.603;39.4261;23.5989;38.6865;46.0459;24.577;51.338;33.4848;39.4215;22.3101;41.1311;13.9582;53.6991;83.8302 86.0232;24.5771;109.875;39.6721;46.6318;264.141;46.786;109.049;148.796;40.5656;327.378;63.9031;106.603;38.3337;132.851;336.862;224.488;129.44 8 10 8 24825;78968;362282;24450;29680;58919;25612;81639 TF_10003;SREBF1_32750;PCK1_9439;HMGCS2_8812;CYP11A1_32785;CCND1_8224;ASNS_8091;ALOX15_8036 45.254183749999996 37.15875 34.964590653330546 32.59989375 29.030900000000003 26.723008103113237 80.87535 52.234350000000006 67.18795044259903 51.412;11.2357;5.51457;30.5985;43.719;28.2655;85.6642;105.624 36.6131;4.94421;1.34064;24.577;33.4848;22.3101;53.6991;83.8302 86.0232;24.5771;39.6721;40.5656;63.9031;38.3337;224.488;129.44 10 360918;114519;24587;286918;24516;79438;24367;84032;24770;287562 PF4_32963;NFIL3_9304;NEFH_33218;MX2_9268;JUN_8938;IGFALS_8880;FGG_8639;COL3A1_8354;CCL2_8218;CCL12_8217 61.86445999999999 60.94355 26.63790141005027 37.30613 39.4238 12.660209756999373 162.89728 121.363 107.78016902434943 105.82;33.1149;79.3182;31.6605;57.7663;70.3663;93.1824;57.8774;64.0097;25.5289 53.8521;25.603;39.4261;23.5989;38.6865;46.0459;51.338;39.4215;41.1311;13.9582 109.875;46.6318;264.141;46.786;109.049;148.796;327.378;106.603;132.851;336.862 0 Exp 2,9(0.5);Exp 3,1(0.06);Hill,2(0.12);Linear,4(0.23);Poly 2,2(0.12) 1.970451232417168 36.623093008995056 1.5230457782745361 3.3687045574188232 0.5608197992654174 1.803471326828003 40.23419309917965 68.73003690082035 26.153438389456127 44.27550049943275 80.78543747174541 172.10074030603238 CONFLICT 0.4444444444444444 0.5555555555555556 0.0 GO:0001525 4 angiogenesis 67 72 6 5 6 4 3 3 66 69 2409 0.87124 0.30941 0.44395 4.17 290350;24516;287562 loxl2;jun;ccl12 LOXL2_9150;JUN_8938;CCL12_8217 49.57953333333333 57.7663 25.5289 21.179215965264945 45.98317423588802 22.48546055927312 32.1354 38.6865 13.9582 15.945120135326675 29.392930688389168 16.91979945100445 191.76800000000003 129.393 109.049 126.06613824100425 215.69902308398352 131.903686624499 65.4434;57.7663;25.5289 43.7615;38.6865;13.9582 129.393;109.049;336.862 0 3 0 3 290350;24516;287562 LOXL2_9150;JUN_8938;CCL12_8217 49.57953333333333 57.7663 21.179215965264945 32.1354 38.6865 15.945120135326675 191.76800000000003 129.393 126.06613824100425 65.4434;57.7663;25.5289 43.7615;38.6865;13.9582 129.393;109.049;336.862 0 Exp 2,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 1.5942954792023227 4.791857123374939 1.5230457782745361 1.7373461723327637 0.12136894926838913 1.5314651727676392 25.6129942973423 73.54607236932436 14.091797971312122 50.17900202868789 49.11073505568481 334.42526494431524 DOWN 0.0 1.0 0.0 GO:0045471 5 response to ethanol 109 117 6 6 6 6 6 6 63 111 2367 0.96329 0.094265 0.13152 5.13 78968;24777;24450;25086;58919;24770 srebf1;slc10a1;hmgcs2;cyp2e1;ccnd1;ccl2 SREBF1_32750;SLC10A1_9832;HMGCS2_8812;CYP2E1_8421;CCND1_8224;CCL2_8218 31.938319999999994 29.432000000000002 7.96762 21.713242509675986 30.543996608002658 18.715055532253114 21.005926666666667 23.443550000000002 4.94421 13.684177921704567 21.384983624439656 11.728961256123425 53.23523333333333 39.449650000000005 11.4863 43.869551693887495 47.92694664203886 38.20124601710616 4.5 56.7813 11.2357;7.96762;30.5985;49.5529;28.2655;64.0097 4.94421;6.07525;24.577;26.9979;22.3101;41.1311 24.5771;11.4863;40.5656;71.5977;38.3337;132.851 4 2 4 78968;24450;25086;58919 SREBF1_32750;HMGCS2_8812;CYP2E1_8421;CCND1_8224 29.91315 29.432000000000002 15.681744946593154 19.7073025 23.443550000000002 10.026468647835337 43.768525000000004 39.449650000000005 19.854217235031776 11.2357;30.5985;49.5529;28.2655 4.94421;24.577;26.9979;22.3101 24.5771;40.5656;71.5977;38.3337 2 24777;24770 SLC10A1_9832;CCL2_8218 35.988659999999996 35.988659999999996 39.62773479979899 23.603175 23.603175 24.78822925525844 72.16865 72.16865 85.81780236667099 7.96762;64.0097 6.07525;41.1311 11.4863;132.851 0 Exp 2,2(0.34);Hill,1(0.17);Linear,1(0.17);Poly 2,2(0.34) 2.3849942539445443 14.710157752037048 1.559963583946228 3.3687045574188232 0.6158207129428829 2.360251307487488 14.564107495395106 49.31253250460489 10.056303870505777 31.95554946282755 18.13228114773989 88.33818551892678 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0021987 4 cerebral cortex development 30 34 3 3 3 3 3 3 66 31 2447 0.9876 0.062612 0.062612 8.82 24587;84032;289054 nefh;col3a1;aspm NEFH_33218;COL3A1_8354;ASPM_8092 49.173033333333336 57.8774 10.3235 35.31135307975797 60.893206882660486 35.08759652011504 28.769566666666666 39.4215 7.4611 18.45367359235914 31.97066098397188 16.555068728678947 129.2021 106.603 16.8623 125.17878557898698 189.32154318162338 130.56248703579445 0.5 34.10045 79.3182;57.8774;10.3235 39.4261;39.4215;7.4611 264.141;106.603;16.8623 1 2 1 289054 ASPM_8092 10.3235 10.3235 7.4611 7.4611 16.8623 16.8623 10.3235 7.4611 16.8623 2 24587;84032 NEFH_33218;COL3A1_8354 68.5978 68.5978 15.16093507406452 39.4238 39.4238 0.0032526911904005393 185.372 185.372 111.39618809456631 79.3182;57.8774 39.4261;39.4215 264.141;106.603 0 Exp 2,2(0.67);Poly 2,1(0.34) 1.6312037775873502 4.901865005493164 1.5452834367752075 1.7671042680740356 0.11740877193248707 1.589477300643921 9.214475689478874 89.1315909771878 7.88726917113803 49.65186416219531 -12.451030879682833 270.85523087968284 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:1902895 10 positive regulation of pri-miRNA transcription by RNA polymerase II 28 29 2 2 2 2 2 2 67 27 2451 0.95795 0.18446 0.18446 6.9 78968;24516 srebf1;jun SREBF1_32750;JUN_8938 34.501 34.501 11.2357 32.902102792678775 45.26223110868973 29.170878941690056 21.815355 21.815355 4.94421 23.859402071763036 29.619006378371015 21.15365494546385 66.81305 66.81305 24.5771 59.730653309711926 86.34904648597113 52.95696958290993 0.5 34.501 11.2357;57.7663 4.94421;38.6865 24.5771;109.049 1 1 1 78968 SREBF1_32750 11.2357 11.2357 4.94421 4.94421 24.5771 24.5771 11.2357 4.94421 24.5771 1 24516 JUN_8938 57.7663 57.7663 38.6865 38.6865 109.049 109.049 57.7663 38.6865 109.049 0 Exp 2,1(0.5);Hill,1(0.5) 2.0861401420431838 4.380465269088745 1.5230457782745361 2.857419490814209 0.9435447007738715 2.1902326345443726 -11.098987999999999 80.100988 -11.2520892 54.88279920000001 -15.969411999999991 149.59551199999999 CONFLICT 0.5 0.5 0.0 GO:0007010 6 cytoskeleton organization 170 184 8 8 8 5 5 5 64 179 2299 0.61906 0.56563 1.0 2.72 24587;303575;24770;287562;289054 nefh;kif18b;ccl2;ccl12;aspm NEFH_33218;KIF18B_32882;CCL2_8218;CCL12_8217;ASPM_8092 36.57142 25.5289 3.6768 33.440592798827595 41.20180317466411 32.59998757132677 20.619368 13.9582 1.12034 18.521255269206783 22.1048436 16.929124698594276 152.49304 132.851 11.7489 145.81460891856136 219.3929097351248 142.09245918197146 79.3182;3.6768;64.0097;25.5289;10.3235 39.4261;1.12034;41.1311;13.9582;7.4611 264.141;11.7489;132.851;336.862;16.8623 2 3 2 303575;289054 KIF18B_32882;ASPM_8092 7.00015 7.00015 4.699926642512625 4.29072 4.29072 4.483594393876412 14.305600000000002 14.305600000000002 3.615719814919288 3.6768;10.3235 1.12034;7.4611 11.7489;16.8623 3 24587;24770;287562 NEFH_33218;CCL2_8218;CCL12_8217 56.28560000000001 64.0097 27.71404858965934 31.505133333333333 39.4261 15.219983847012895 244.61800000000002 264.141 103.39720826502042 79.3182;64.0097;25.5289 39.4261;41.1311;13.9582 264.141;132.851;336.862 0 Exp 2,2(0.4);Exp 4,1(0.2);Poly 2,2(0.4) 1.6489947633140947 8.272795677185059 1.5314651727676392 1.8689792156219482 0.15385382510058024 1.559963583946228 7.259448027221168 65.88339197277884 4.38477196225557 36.85396403774443 24.680899959455473 280.30518004054454 DOWN 0.4 0.6 0.0 GO:0032409 4 regulation of transporter activity 61 63 3 3 3 3 3 3 66 60 2418 0.91097 0.24237 0.24237 4.76 100911740;24770;25649 mrln;ccl2;apoa2 LOC100911740_32571;CCL2_8218;APOA2_33095 78.39856666666667 80.183 64.0097 13.584833932122047 77.8761565006169 9.809388696317734 48.665166666666664 50.2978 41.1311 6.864931446368107 48.785095874460204 5.180806089470131 201.11566666666667 197.161 132.851 70.3254442242161 191.63870835903762 47.48208528929377 91.003;64.0097;80.183 54.5666;41.1311;50.2978 273.335;132.851;197.161 1 2 1 25649 APOA2_33095 80.183 80.183 50.2978 50.2978 197.161 197.161 80.183 50.2978 197.161 2 100911740;24770 LOC100911740_32571;CCL2_8218 77.50635 77.50635 19.08714547660279 47.84885 47.84885 9.500333158631918 203.093 203.093 99.3371890482109 91.003;64.0097 54.5666;41.1311 273.335;132.851 0 Exp 2,1(0.34);Linear,2(0.67) 1.7741554016310492 5.347227573394775 1.559963583946228 1.9712703227996826 0.20769989432687178 1.8159936666488647 63.025879912556945 93.77125342077639 40.896765430349944 56.433567902983384 121.53493492535354 280.6963984079798 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0015031 5 protein transport 172 184 6 6 6 6 6 6 63 178 2300 0.77239 0.38094 0.63385 3.26 286918;85430;24367;170568;114851;29657 mx2;herpud1;fgg;dmbt1;cdkn1a;arntl MX2_9268;HERPUD1_8795;FGG_8639;DMBT1_32993;CDKN1A_8271;ARNTL_8086 48.87413333333333 46.055350000000004 21.7434 25.16564104565324 42.969987200475835 19.07780941564269 31.82768333333333 32.5374 12.6557 13.54570182447801 29.33478729111199 11.316024626116292 130.82965000000002 93.56275 46.786 103.85242289421558 99.98290940916559 75.45311206854954 31.6605;53.893;93.1824;21.7434;54.5478;38.2177 23.5989;37.9512;51.338;12.6557;38.2987;27.1236 46.786;92.6554;327.378;160.485;94.4701;63.2034 2 4 2 85430;170568 HERPUD1_8795;DMBT1_32993 37.818200000000004 37.818200000000004 22.73320017243502 25.303449999999998 25.303449999999998 17.886619583504316 126.5702 126.5702 47.96277012517113 53.893;21.7434 37.9512;12.6557 92.6554;160.485 4 286918;24367;114851;29657 MX2_9268;FGG_8639;CDKN1A_8271;ARNTL_8086 54.4021 46.38275 27.58651887244929 35.0898 32.711149999999996 12.514021039085193 132.959375 78.83675 131.11289365022736 31.6605;93.1824;54.5478;38.2177 23.5989;51.338;38.2987;27.1236 46.786;327.378;94.4701;63.2034 0 Exp 2,2(0.34);Linear,2(0.34);Poly 2,1(0.17);Power,1(0.17) 2.1579683267249328 14.253994703292847 1.5270863771438599 4.897102355957031 1.302466579400427 1.7867212891578674 28.73742666011563 69.01084000655104 20.98886449189964 42.66650217476703 47.7304047500964 213.92889524990358 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0071378 7 cellular response to growth hormone stimulus 5 5 1 1 1 1 1 1 68 4 2474 0.99314 0.12841 0.12841 20.0 79438 igfals IGFALS_8880 70.3663 70.3663 70.3663 70.3663 46.0459 46.0459 46.0459 46.0459 148.796 148.796 148.796 148.796 0.0 70.3663 0.0 70.3663 70.3663 46.0459 148.796 0 1 0 1 79438 IGFALS_8880 70.3663 70.3663 46.0459 46.0459 148.796 148.796 70.3663 46.0459 148.796 0 Linear,1(1) 1.527578592300415 1.527578592300415 1.527578592300415 1.527578592300415 0.0 1.527578592300415 70.3663 70.3663 46.0459 46.0459 148.796 148.796 DOWN 0.0 1.0 0.0 GO:0050766 6 positive regulation of phagocytosis 30 35 2 2 2 2 2 2 67 33 2445 0.9328 0.24469 0.24469 5.71 24770;25649 ccl2;apoa2 CCL2_8218;APOA2_33095 72.09635 72.09635 64.0097 11.436250104164364 76.25179493067591 9.810829287131556 45.71445 45.71445 41.1311 6.481835731102772 48.069672313691505 5.560580019312736 165.006 165.006 132.851 45.47403709810688 181.5293232235702 39.01086552870698 0.5 72.09635 64.0097;80.183 41.1311;50.2978 132.851;197.161 1 1 1 25649 APOA2_33095 80.183 80.183 50.2978 50.2978 197.161 197.161 80.183 50.2978 197.161 1 24770 CCL2_8218 64.0097 64.0097 41.1311 41.1311 132.851 132.851 64.0097 41.1311 132.851 0 Exp 2,1(0.5);Linear,1(0.5) 1.753599132550376 3.5312339067459106 1.559963583946228 1.9712703227996826 0.29083778419100215 1.7656169533729553 56.24651599999999 87.94618400000002 36.731084 54.697815999999996 101.9822 228.0298 CONFLICT 0.5 0.5 0.0 GO:0008203 6 cholesterol metabolic process 48 49 5 5 4 5 4 4 65 45 2433 0.99046 0.041857 0.041857 8.16 78968;24450;29680;25649 srebf1;hmgcs2;cyp11a1;apoa2 SREBF1_32750;HMGCS2_8812;CYP11A1_32785;APOA2_33095 41.43405 37.15875 11.2357 29.074912491298527 52.88265210302709 30.559887345611475 28.3259525 29.030900000000003 4.94421 18.88682360161069 35.34174630536378 17.86344460352234 81.55170000000001 52.234350000000006 24.5771 78.74632005543708 113.86547697822624 90.06553567304695 1.5 37.15875 11.2357;30.5985;43.719;80.183 4.94421;24.577;33.4848;50.2978 24.5771;40.5656;63.9031;197.161 4 0 4 78968;24450;29680;25649 SREBF1_32750;HMGCS2_8812;CYP11A1_32785;APOA2_33095 41.43405 37.15875 29.074912491298527 28.3259525 29.030900000000003 18.88682360161069 81.55170000000001 52.234350000000006 78.74632005543708 11.2357;30.5985;43.719;80.183 4.94421;24.577;33.4848;50.2978 24.5771;40.5656;63.9031;197.161 0 0 Exp 2,2(0.5);Hill,1(0.25);Linear,1(0.25) 2.401468307202727 9.950161933898926 1.752767562866211 3.3687045574188232 0.7571188213535138 2.414344906806946 12.940635758527446 69.92746424147255 9.816865370421528 46.835039629578475 4.380306345671656 158.72309365432835 UP 1.0 0.0 0.0 GO:0051235 3 maintenance of location 47 50 3 3 2 3 2 2 67 48 2430 0.84811 0.39522 0.39522 4.0 299691;289054 cry1;aspm CRY1_8386;ASPM_8092 23.78915 23.78915 10.3235 19.04330485616927 30.841351085244185 16.222835126806952 14.670449999999999 14.670449999999999 7.4611 10.195560545894473 18.44611518466655 8.685514358493318 45.343700000000005 45.343700000000005 16.8623 40.278782155373065 60.2599171888675 34.31316396762428 37.2548;10.3235 21.8798;7.4611 73.8251;16.8623 1 1 1 289054 ASPM_8092 10.3235 10.3235 7.4611 7.4611 16.8623 16.8623 10.3235 7.4611 16.8623 1 299691 CRY1_8386 37.2548 37.2548 21.8798 21.8798 73.8251 73.8251 37.2548 21.8798 73.8251 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.6963784358364098 3.407530665397644 1.5452834367752075 1.8622472286224365 0.22412724660577696 1.703765332698822 -2.6035240000000073 50.181824000000006 0.5401239999999987 28.800776 -10.479844 101.16724400000001 CONFLICT 0.5 0.5 0.0 GO:0007623 3 circadian rhythm 58 63 10 10 9 9 8 8 61 55 2423 0.99997 2.2696E-4 2.2696E-4 12.7 78968;316351;114519;24516;24309;299691;282840;29657 srebf1;npas2;nfil3;jun;dbp;cry1;atf5;arntl SREBF1_32750;NPAS2_9350;NFIL3_9304;JUN_8938;DBP_8439;CRY1_8386;ATF5_8097;ARNTL_8086 48.0590125 44.456450000000004 11.2357 25.31870820133025 53.28450464485272 25.484491384219936 33.728801250000004 31.4593 4.94421 20.267302310188793 37.18551909977236 20.94543581955041 73.88211249999999 68.51425 24.5771 31.752515196862223 82.18189214973901 27.934320049624905 2.5 37.73625 5.5 57.99875 11.2357;58.2312;33.1149;57.7663;50.6952;37.2548;97.9563;38.2177 4.94421;35.795;25.603;38.6865;40.5862;21.8798;75.2121;27.1236 24.5771;99.4319;46.6318;109.049;59.5346;73.8251;114.804;63.2034 1 7 1 78968 SREBF1_32750 11.2357 11.2357 4.94421 4.94421 24.5771 24.5771 11.2357 4.94421 24.5771 7 316351;114519;24516;24309;299691;282840;29657 NPAS2_9350;NFIL3_9304;JUN_8938;DBP_8439;CRY1_8386;ATF5_8097;ARNTL_8086 53.31948571428571 50.6952 22.126885992492543 37.84088571428571 35.795 17.927759836859035 80.9256857142857 73.8251 26.706078666003446 58.2312;33.1149;57.7663;50.6952;37.2548;97.9563;38.2177 35.795;25.603;38.6865;40.5862;21.8798;75.2121;27.1236 99.4319;46.6318;109.049;59.5346;73.8251;114.804;63.2034 0 Exp 2,2(0.25);Hill,1(0.13);Linear,1(0.13);Poly 2,2(0.25);Power,2(0.25) 3.0468870246565958 26.920154094696045 1.5230457782745361 5.737884044647217 1.5695804255348527 2.846481442451477 30.51404284515682 65.60398215484318 19.684277288105562 47.77332521189443 51.87874206087845 95.88548293912156 DOWN 0.125 0.875 0.0 GO:0019725 4 cellular homeostasis 217 230 8 6 7 7 6 6 63 224 2254 0.56728 0.60221 1.0 2.61 24825;362282;85430;24770;287562;81639 tf;pck1;herpud1;ccl2;ccl12;alox15 TF_10003;PCK1_9439;HERPUD1_8795;CCL2_8218;CCL12_8217;ALOX15_8036 50.99702833333333 52.6525 5.51457 34.29073953008328 54.71740719340126 35.228806928813626 35.80407333333333 37.28215 1.34064 28.302371461053706 38.94007976484002 30.22803900424359 136.25061666666667 111.04769999999999 39.6721 103.97462690342135 185.23634285256185 122.15520768384583 51.412;5.51457;53.893;64.0097;25.5289;105.624 36.6131;1.34064;37.9512;41.1311;13.9582;83.8302 86.0232;39.6721;92.6554;132.851;336.862;129.44 4 2 4 24825;362282;85430;81639 TF_10003;PCK1_9439;HERPUD1_8795;ALOX15_8036 54.1108925 52.6525 40.91672153166182 39.933785 37.28215 33.819539140338684 86.947675 89.33930000000001 36.85109882661797 51.412;5.51457;53.893;105.624 36.6131;1.34064;37.9512;83.8302 86.0232;39.6721;92.6554;129.44 2 24770;287562 CCL2_8218;CCL12_8217 44.7693 44.7693 27.210034625483285 27.54465 27.54465 19.214141854503943 234.8565 234.8565 144.2575615366488 64.0097;25.5289 41.1311;13.9582 132.851;336.862 0 Exp 2,1(0.17);Hill,1(0.17);Linear,2(0.34);Poly 2,2(0.34) 1.7529119964153708 10.659761428833008 1.5270863771438599 2.3449018001556396 0.33214847796458646 1.6257085800170898 23.558722181213028 78.43533448545364 13.157459593838475 58.450687072828195 53.053587844184776 219.44764548914856 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0033157 7 regulation of intracellular protein transport 69 73 5 5 4 4 3 3 66 70 2408 0.86642 0.31695 0.44773 4.11 78968;361921;24770 srebf1;ect2;ccl2 SREBF1_32750;ECT2_8523;CCL2_8218 29.886533333333333 14.4142 11.2357 29.594232429365913 29.937008716989947 29.1781400558868 18.55588666666667 9.59235 4.94421 19.688359356458157 18.857997759990653 19.176262949765185 62.501133333333335 30.0753 24.5771 60.986763775620474 62.49384287216639 60.22610312459924 11.2357;14.4142;64.0097 4.94421;9.59235;41.1311 24.5771;30.0753;132.851 2 1 2 78968;361921 SREBF1_32750;ECT2_8523 12.82495 12.82495 2.247538904001446 7.26828 7.26828 3.286731313904439 27.3262 27.3262 3.8878145043198633 11.2357;14.4142 4.94421;9.59235 24.5771;30.0753 1 24770 CCL2_8218 64.0097 64.0097 41.1311 41.1311 132.851 132.851 64.0097 41.1311 132.851 0 Exp 2,1(0.34);Hill,1(0.34);Poly 2,1(0.34) 1.9944245643654095 6.197155117988586 1.559963583946228 2.857419490814209 0.694386013003245 1.7797720432281494 -3.6024932633940026 63.37555993006067 -3.723589299065612 40.835362632398954 -6.511886653069517 131.51415331973618 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0030001 7 metal ion transport 103 108 4 4 4 3 3 3 66 105 2373 0.66463 0.56744 0.76737 2.78 24825;24777;287562 tf;slc10a1;ccl12 TF_10003;SLC10A1_9832;CCL12_8217 28.302840000000003 25.5289 7.96762 21.854624127145254 27.559462338642543 18.38652816407426 18.882183333333334 13.9582 6.07525 15.853210386411751 17.472147613630057 13.58807212984807 144.7905 86.0232 11.4863 170.4627032508578 202.25080562184365 178.62063488212596 51.412;7.96762;25.5289 36.6131;6.07525;13.9582 86.0232;11.4863;336.862 1 2 1 24825 TF_10003 51.412 51.412 36.6131 36.6131 86.0232 86.0232 51.412 36.6131 86.0232 2 24777;287562 SLC10A1_9832;CCL12_8217 16.748260000000002 16.748260000000002 12.417700174315687 10.016725 10.016725 5.574087400754495 174.17415 174.17415 230.07536390331975 7.96762;25.5289 6.07525;13.9582 11.4863;336.862 0 Linear,1(0.34);Poly 2,2(0.67) 1.9601742463330398 5.989291787147522 1.5314651727676392 2.4529356956481934 0.4607935155073147 2.0048909187316895 3.572004679222996 53.03367532077701 0.9425869764687285 36.82177969019794 -48.10620771300111 337.68720771300116 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0043085 5 positive regulation of catalytic activity 340 363 12 12 10 10 9 9 60 354 2124 0.46936 0.66764 1.0 2.48 24825;24516;361921;498709;114851;58919;24770;287562;25649 tf;jun;ect2;cks2;cdkn1a;ccnd1;ccl2;ccl12;apoa2 TF_10003;JUN_8938;ECT2_8523;CKS2_8325;CDKN1A_8271;CCND1_8224;CCL2_8218;CCL12_8217;APOA2_33095 43.39412222222222 51.412 14.4142 23.45492584691848 46.1069791281962 23.233290724045226 28.94571666666667 36.6131 9.59235 15.256551921264837 30.49333097574667 15.150515676736081 117.10234444444444 94.4701 29.0958 98.75351919881277 145.22590087490082 111.76969775277071 51.412;57.7663;14.4142;14.4197;54.5478;28.2655;64.0097;25.5289;80.183 36.6131;38.6865;9.59235;9.6236;38.2987;22.3101;41.1311;13.9582;50.2978 86.0232;109.049;30.0753;29.0958;94.4701;38.3337;132.851;336.862;197.161 5 4 5 24825;361921;498709;58919;25649 TF_10003;ECT2_8523;CKS2_8325;CCND1_8224;APOA2_33095 37.73888000000001 28.2655 28.13373115455893 25.68739 22.3101 17.70271991024261 76.1378 38.3337 71.60340375718883 51.412;14.4142;14.4197;28.2655;80.183 36.6131;9.59235;9.6236;22.3101;50.2978 86.0232;30.0753;29.0958;38.3337;197.161 4 24516;114851;24770;287562 JUN_8938;CDKN1A_8271;CCL2_8218;CCL12_8217 50.46317500000001 56.15705 17.080653827332426 33.018625 38.492599999999996 12.768660211986479 168.308025 120.95 113.47733154307006 57.7663;54.5478;64.0097;25.5289 38.6865;38.2987;41.1311;13.9582 109.049;94.4701;132.851;336.862 0 Exp 2,2(0.23);Linear,4(0.45);Poly 2,3(0.34) 1.7421745518992724 15.833020210266113 1.5230457782745361 2.2675669193267822 0.2675789515914037 1.6645443439483643 28.07023733556882 58.718007108875625 18.978102744773636 38.913330588559695 52.58337856788677 181.6213103210021 CONFLICT 0.5555555555555556 0.4444444444444444 0.0 GO:0035821 3 modulation of process of other organism 40 42 4 4 4 4 4 4 65 38 2440 0.99507 0.025453 0.025453 9.52 84386;24516;287562;29339 slpi;jun;ccl12;apcs SLPI_9890;JUN_8938;CCL12_8217;APCS_8057 60.442125000000004 57.1428 25.5289 31.436272262719562 58.5465667078765 33.013320436342916 37.618700000000004 39.009 13.9582 18.25617123915453 36.14424598366789 19.446497152829966 235.41 222.95550000000003 100.108 153.00741414497975 250.20936971727886 150.72306076749368 1.5 57.1428 56.5193;57.7663;25.5289;101.954 39.3315;38.6865;13.9582;58.4986 100.108;109.049;336.862;395.621 0 4 0 4 84386;24516;287562;29339 SLPI_9890;JUN_8938;CCL12_8217;APCS_8057 60.442125000000004 57.1428 31.436272262719562 37.618700000000004 39.009 18.25617123915453 235.41 222.95550000000003 153.00741414497975 56.5193;57.7663;25.5289;101.954 39.3315;38.6865;13.9582;58.4986 100.108;109.049;336.862;395.621 0 Exp 2,1(0.25);Linear,2(0.5);Poly 2,1(0.25) 1.5648013794818683 6.261340856552124 1.5230457782745361 1.6244933605194092 0.047343805022838796 1.5569008588790894 29.634578182534796 91.2496718174652 19.72765218562855 55.509747814371444 85.46273413791991 385.3572658620801 DOWN 0.0 1.0 0.0 GO:0032787 7 monocarboxylic acid metabolic process 180 207 13 13 13 12 12 12 57 195 2283 0.99701 0.0083569 0.011011 5.8 29142;25044;83792;362282;81660;171142;29740;24306;25086;499353;25612;81639 vnn1;sds;scd2;pck1;gatm;ehhadh;eci1;cyp4a2;cyp2e1;cyp2c24;asns;alox15 VNN1_10157;SDS_9798;SCD_9786;PCK1_9439;GATM_32792;EHHADH_8534;ECI1_8520;CYP4A2_8425;CYP2E1_8421;CYP2C24_32875;ASNS_8091;ALOX15_8036 54.953639166666676 54.56 5.51457 34.65446311236965 59.70623195074033 32.594798661002464 36.277569166666666 35.7237 1.34064 23.063524563837895 40.75548158334673 22.64317690220282 95.77921666666668 85.59425 17.0471 67.35546684263116 103.02285566629162 66.63384180658005 9.5 94.4476 20.8684;64.7394;83.9984;5.51457;37.423;32.6956;103.231;59.5671;49.5529;10.5651;85.6642;105.624 17.1194;43.4259;54.1928;1.34064;28.03;25.6436;49.9975;43.4174;26.9979;7.63639;53.6991;83.8302 26.5474;126.828;206.18;39.6721;55.6613;45.0542;107.244;99.5908;71.5977;17.0471;224.488;129.44 9 3 9 29142;83792;362282;171142;29740;24306;25086;25612;81639 VNN1_10157;SCD_9786;PCK1_9439;EHHADH_8534;ECI1_8520;CYP4A2_8425;CYP2E1_8421;ASNS_8091;ALOX15_8036 60.74624111111112 59.5671 36.288488154064915 39.58205999999999 43.4174 24.529249648244456 105.53491111111111 99.5908 70.95382785980341 20.8684;83.9984;5.51457;32.6956;103.231;59.5671;49.5529;85.6642;105.624 17.1194;54.1928;1.34064;25.6436;49.9975;43.4174;26.9979;53.6991;83.8302 26.5474;206.18;39.6721;45.0542;107.244;99.5908;71.5977;224.488;129.44 3 25044;81660;499353 SDS_9798;GATM_32792;CYP2C24_32875 37.575833333333335 37.423 27.087473371345165 26.364096666666665 28.03 17.952818217400672 66.51213333333334 55.6613 55.689019916167794 64.7394;37.423;10.5651 43.4259;28.03;7.63639 126.828;55.6613;17.0471 0 Exp 2,6(0.5);Exp 3,1(0.09);Hill,1(0.09);Linear,1(0.09);Poly 2,3(0.25) 1.9843365619108058 24.09270191192627 1.5959433317184448 2.642244338989258 0.32449025365834283 1.916516363620758 35.34603083224904 74.56124750108428 23.22815169358118 49.32698663975215 57.66927369194037 133.88915964139298 UP 0.75 0.25 0.0 GO:0030100 6 regulation of endocytosis 51 53 2 2 2 2 2 2 67 51 2427 0.82826 0.42399 0.65371 3.77 24825;81639 tf;alox15 TF_10003;ALOX15_8036 78.518 78.518 51.412 38.333672821685106 84.48738887869332 37.39255627567959 60.221650000000004 60.221650000000004 36.6131 33.38753159796333 65.42081681959993 32.567846029004464 107.7316 107.7316 86.0232 30.700313697420064 112.51230838685997 29.94660107190158 51.412;105.624 36.6131;83.8302 86.0232;129.44 2 0 2 24825;81639 TF_10003;ALOX15_8036 78.518 78.518 38.333672821685106 60.221650000000004 60.221650000000004 33.38753159796333 107.7316 107.7316 30.700313697420064 51.412;105.624 36.6131;83.8302 86.0232;129.44 0 0 Linear,1(0.5);Poly 2,1(0.5) 1.8415156567770403 3.696344494819641 1.6914535760879517 2.0048909187316895 0.2216336704604784 1.8481722474098206 25.390240000000006 131.64576 13.948892 106.494408 65.183136 150.28006399999998 UP 1.0 0.0 0.0 GO:0001889 6 liver development 91 101 6 5 5 6 5 5 64 96 2382 0.94663 0.13587 0.19485 4.95 24516;24450;24309;58919;25612 jun;hmgcs2;dbp;ccnd1;asns JUN_8938;HMGCS2_8812;DBP_8439;CCND1_8224;ASNS_8091 50.59794 50.6952 28.2655 23.343912009622553 48.741281923662925 24.12013589397942 35.97178 38.6865 22.3101 12.839421352498713 34.46418897136383 13.211939382040764 94.39418 59.5346 38.3337 78.09393304195916 92.50978129077626 78.67145295224648 57.7663;30.5985;50.6952;28.2655;85.6642 38.6865;24.577;40.5862;22.3101;53.6991 109.049;40.5656;59.5346;38.3337;224.488 3 2 3 24450;58919;25612 HMGCS2_8812;CCND1_8224;ASNS_8091 48.176066666666664 30.5985 32.486625368962734 33.528733333333335 24.577 17.504784417505203 101.1291 40.5656 106.83776954481031 30.5985;28.2655;85.6642 24.577;22.3101;53.6991 40.5656;38.3337;224.488 2 24516;24309 JUN_8938;DBP_8439 54.23075 54.23075 5.000022760448193 39.63635 39.63635 1.3432907522202973 84.2918 84.2918 35.011968006383235 57.7663;50.6952 38.6865;40.5862 109.049;59.5346 0 Exp 2,3(0.6);Linear,1(0.2);Poly 2,1(0.2) 2.5439059175524887 14.493144631385803 1.5230457782745361 5.737884044647217 1.7514136246286627 2.2675669193267822 30.13609894719842 71.05978105280158 24.717530977107828 47.22602902289218 25.941829578442068 162.84653042155793 UP 0.6 0.4 0.0 GO:1902531 6 regulation of intracellular signal transduction 377 399 17 17 14 13 12 12 57 387 2091 0.72312 0.39502 0.73631 3.01 29142;24825;29692;24516;85430;24367;116663;84032;24770;287562;29657;81639 vnn1;tf;pla2g2a;jun;herpud1;fgg;dusp6;col3a1;ccl2;ccl12;arntl;alox15 VNN1_10157;TF_10003;PLA2G2A_32641;JUN_8938;HERPUD1_8795;FGG_8639;DUSP6_8506;COL3A1_8354;CCL2_8218;CCL12_8217;ARNTL_8086;ALOX15_8036 51.160633333333436 52.6525 1.16694E-12 29.208503547591857 50.463155826453914 28.697594585651743 35.04035833333343 37.28215 1.16694E-12 20.858185766284326 35.300104958723225 22.54248574144531 123.52926666666677 99.6292 1.16694E-12 104.8936668474345 139.1974935351312 112.45886197022989 20.8684;51.412;1.16694E-12;57.7663;53.893;93.1824;45.5478;57.8774;64.0097;25.5289;38.2177;105.624 17.1194;36.6131;1.16694E-12;38.6865;37.9512;51.338;33.3115;39.4215;41.1311;13.9582;27.1236;83.8302 26.5474;86.0232;1.16694E-12;109.049;92.6554;327.378;71.7388;106.603;132.851;336.862;63.2034;129.44 4 8 4 29142;24825;85430;81639 VNN1_10157;TF_10003;HERPUD1_8795;ALOX15_8036 57.949349999999995 52.6525 35.15233527505678 43.878475 37.28215 28.28489990641355 83.6665 89.33930000000001 42.599527560604066 20.8684;51.412;53.893;105.624 17.1194;36.6131;37.9512;83.8302 26.5474;86.0232;92.6554;129.44 8 29692;24516;24367;116663;84032;24770;287562;29657 PLA2G2A_32641;JUN_8938;FGG_8639;DUSP6_8506;COL3A1_8354;CCL2_8218;CCL12_8217;ARNTL_8086 47.76627500000015 51.65705 27.776977632140127 30.621300000000147 35.999 16.54829521923171 143.46065000000016 107.826 123.08597143496297 1.16694E-12;57.7663;93.1824;45.5478;57.8774;64.0097;25.5289;38.2177 1.16694E-12;38.6865;51.338;33.3115;39.4215;41.1311;13.9582;27.1236 1.16694E-12;109.049;327.378;71.7388;106.603;132.851;336.862;63.2034 0 Exp 2,5(0.42);Hill,1(0.09);Linear,3(0.25);Poly 2,2(0.17);Power,1(0.09) 1.9065000429887957 24.43163549900055 1.5230457782745361 4.897102355957031 0.9588610608408871 1.6404654383659363 34.6343666952217 67.68689997144517 23.238728749701387 46.841987916965486 64.18008761182662 182.87844572150695 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0071347 7 cellular response to interleukin-1 47 50 6 6 6 6 6 6 63 44 2434 0.99969 0.0019698 0.0019698 12.0 362282;79438;24367;29680;24770;287562 pck1;igfals;fgg;cyp11a1;ccl2;ccl12 PCK1_9439;IGFALS_8880;FGG_8639;CYP11A1_32785;CCL2_8218;CCL12_8217 50.38681166666667 53.86435 5.51457 31.91275286916528 48.415604745548116 27.88358100428947 31.216440000000002 37.307950000000005 1.34064 19.58900852145407 29.90598220388826 18.087385215715702 174.91036666666665 140.8235 39.6721 128.481643239969 223.92112191226926 121.54626732473616 1.5 34.62395 4.0 70.3663 5.51457;70.3663;93.1824;43.719;64.0097;25.5289 1.34064;46.0459;51.338;33.4848;41.1311;13.9582 39.6721;148.796;327.378;63.9031;132.851;336.862 2 4 2 362282;29680 PCK1_9439;CYP11A1_32785 24.616785 24.616785 27.01461152436677 17.41272 17.41272 22.729353511545373 51.7876 51.7876 17.133904414931287 5.51457;43.719 1.34064;33.4848 39.6721;63.9031 4 79438;24367;24770;287562 IGFALS_8880;FGG_8639;CCL2_8218;CCL12_8217 63.271825 67.18799999999999 28.107216863452827 38.1183 43.5885 16.637254437957417 236.47175 238.087 110.70447981412796 70.3663;93.1824;64.0097;25.5289 46.0459;51.338;41.1311;13.9582 148.796;327.378;132.851;336.862 0 Exp 2,3(0.5);Hill,1(0.17);Linear,1(0.17);Poly 2,1(0.17) 1.7490792410759648 10.625574946403503 1.527578592300415 2.3449018001556396 0.31933646049272385 1.6563655734062195 24.851291133115033 75.9223322002183 15.541968688099288 46.89091131190071 72.10364069760433 277.71709263572905 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0071214 4 cellular response to abiotic stimulus 122 125 5 5 4 4 3 3 66 122 2356 0.5582 0.66802 1.0 2.4 362282;361921;114851 pck1;ect2;cdkn1a PCK1_9439;ECT2_8523;CDKN1A_8271 24.825523333333336 14.4142 5.51457 26.12204339674891 38.52149941443088 25.405084791362242 16.410563333333332 9.59235 1.34064 19.39949933722603 26.64570989692228 18.550831539265733 54.73916666666667 39.6721 30.0753 34.74096918932075 71.15924467431829 36.8394523338466 5.51457;14.4142;54.5478 1.34064;9.59235;38.2987 39.6721;30.0753;94.4701 2 1 2 362282;361921 PCK1_9439;ECT2_8523 9.964385 9.964385 6.292988723051229 5.466495 5.466495 5.834840097384847 34.8737 34.8737 6.78596235769107 5.51457;14.4142 1.34064;9.59235 39.6721;30.0753 1 114851 CDKN1A_8271 54.5478 54.5478 38.2987 38.2987 94.4701 94.4701 54.5478 38.2987 94.4701 0 Hill,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 1.908072196815582 5.789218187332153 1.6645443439483643 2.3449018001556396 0.3641280299251605 1.7797720432281494 -4.734351488982963 54.38539815564964 -5.542036749069844 38.36316341573651 15.426059156475525 94.0522741768578 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0104004 4 cellular response to environmental stimulus 122 125 5 5 4 4 3 3 66 122 2356 0.5582 0.66802 1.0 2.4 362282;361921;114851 pck1;ect2;cdkn1a PCK1_9439;ECT2_8523;CDKN1A_8271 24.825523333333336 14.4142 5.51457 26.12204339674891 38.52149941443088 25.405084791362242 16.410563333333332 9.59235 1.34064 19.39949933722603 26.64570989692228 18.550831539265733 54.73916666666667 39.6721 30.0753 34.74096918932075 71.15924467431829 36.8394523338466 5.51457;14.4142;54.5478 1.34064;9.59235;38.2987 39.6721;30.0753;94.4701 2 1 2 362282;361921 PCK1_9439;ECT2_8523 9.964385 9.964385 6.292988723051229 5.466495 5.466495 5.834840097384847 34.8737 34.8737 6.78596235769107 5.51457;14.4142 1.34064;9.59235 39.6721;30.0753 1 114851 CDKN1A_8271 54.5478 54.5478 38.2987 38.2987 94.4701 94.4701 54.5478 38.2987 94.4701 0 Hill,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 1.908072196815582 5.789218187332153 1.6645443439483643 2.3449018001556396 0.3641280299251605 1.7797720432281494 -4.734351488982963 54.38539815564964 -5.542036749069844 38.36316341573651 15.426059156475525 94.0522741768578 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0051656 4 establishment of organelle localization 52 55 2 2 2 2 2 2 67 53 2425 0.81464 0.4428 0.65998 3.64 314654;293502 myo1f;kif22 MYO1F_32715;KIF22_8963 52.598349999999996 52.598349999999996 13.2391 55.662385154833245 55.527223853211 55.508058126986896 35.076595 35.076595 9.02099 36.84818996683622 37.015493231396526 36.74602633113716 68.07095 68.07095 25.4349 60.2964801560174 71.24366320081549 60.12930484460752 91.9576;13.2391 61.1322;9.02099 110.707;25.4349 2 0 2 314654;293502 MYO1F_32715;KIF22_8963 52.598349999999996 52.598349999999996 55.662385154833245 35.076595 35.076595 36.84818996683622 68.07095 68.07095 60.2964801560174 91.9576;13.2391 61.1322;9.02099 110.707;25.4349 0 0 Poly 2,2(1) 1.6015123989364648 3.2031694650650024 1.5863633155822754 1.616806149482727 0.021526334289545083 1.6015847325325012 -24.545779999999993 129.74248 -15.992390799999988 86.14558079999998 -15.495707999999993 151.637608 UP 1.0 0.0 0.0 GO:0071229 5 cellular response to acid chemical 95 99 5 5 5 5 5 5 64 94 2384 0.95079 0.12776 0.19021 5.05 78968;362282;24450;84032;24770 srebf1;pck1;hmgcs2;col3a1;ccl2 SREBF1_32750;PCK1_9439;HMGCS2_8812;COL3A1_8354;CCL2_8218 33.847173999999995 30.5985 5.51457 26.513198717542174 34.66869707208197 22.340309742392446 22.282890000000002 24.577 1.34064 18.66452231395971 24.178522364434695 15.273847582082283 68.85376 40.5656 24.5771 47.78300886688698 63.24780892791806 45.77112739337332 3.5 60.94355 11.2357;5.51457;30.5985;57.8774;64.0097 4.94421;1.34064;24.577;39.4215;41.1311 24.5771;39.6721;40.5656;106.603;132.851 3 2 3 78968;362282;24450 SREBF1_32750;PCK1_9439;HMGCS2_8812 15.782923333333335 11.2357 13.145676707329802 10.287283333333335 4.94421 12.50573592382445 34.93826666666667 39.6721 8.98414807220658 11.2357;5.51457;30.5985 4.94421;1.34064;24.577 24.5771;39.6721;40.5656 2 84032;24770 COL3A1_8354;CCL2_8218 60.94355 60.94355 4.336190914270134 40.276300000000006 40.276300000000006 1.208869753116359 119.727 119.727 18.560138792584475 57.8774;64.0097 39.4215;41.1311 106.603;132.851 0 Exp 2,3(0.6);Hill,2(0.4) 2.2365884378114345 11.72046673297882 1.559963583946228 3.3687045574188232 0.7901957635232616 2.3449018001556396 10.607330663713256 57.087017336286735 5.922714860662374 38.64306513933763 26.970106049632875 110.73741395036711 UP 0.6 0.4 0.0 GO:0032355 5 response to estradiol 114 121 7 7 5 5 4 4 65 117 2361 0.77183 0.41698 0.56773 3.31 24587;360504;58919;24770 nefh;hba-a2;ccnd1;ccl2 NEFH_33218;HBA2_32600;CCND1_8224;CCL2_8218 68.24985000000001 71.66395 28.2655 30.760178648646768 61.219663329078095 29.115362304199014 46.877700000000004 40.2786 22.3101 26.572996152234435 37.337930027196535 18.390933405063464 137.81967500000002 124.402 38.3337 93.73255496049649 155.23612931675643 114.9640670475595 79.3182;101.406;28.2655;64.0097 39.4261;84.6435;22.3101;41.1311 264.141;115.953;38.3337;132.851 2 2 2 360504;58919 HBA2_32600;CCND1_8224 64.83575 64.83575 51.718143529374686 53.4768 53.4768 44.07636983441355 77.14335 77.14335 54.88513338095301 101.406;28.2655 84.6435;22.3101 115.953;38.3337 2 24587;24770 NEFH_33218;CCL2_8218 71.66395 71.66395 10.824744159794273 40.2786 40.2786 1.2056170619233415 198.496 198.496 92.83604930198187 79.3182;64.0097 39.4261;41.1311 264.141;132.851 0 Exp 2,2(0.5);Linear,1(0.25);Poly 2,1(0.25) 1.8258889253051351 7.372753143310547 1.559963583946228 2.2675669193267822 0.3001867906122404 1.7726113200187683 38.10487492432615 98.39482507567388 20.83616377081024 72.91923622918976 45.96177113871342 229.67757886128663 CONFLICT 0.5 0.5 0.0 GO:0007179 8 transforming growth factor beta receptor signaling pathway 27 29 3 3 3 3 3 3 66 26 2452 0.99297 0.042049 0.042049 10.34 24516;84032;24770 jun;col3a1;ccl2 JUN_8938;COL3A1_8354;CCL2_8218 59.88446666666666 57.8774 57.7663 3.572988713015347 59.63561745023294 3.4824409356373174 39.74636666666667 39.4215 38.6865 1.2542611583451135 39.511420902160104 1.3231379555253635 116.16766666666666 109.049 106.603 14.49985990736934 115.78959614570097 13.618248886303506 0.5 57.82185 1.5 60.94355 57.7663;57.8774;64.0097 38.6865;39.4215;41.1311 109.049;106.603;132.851 0 3 0 3 24516;84032;24770 JUN_8938;COL3A1_8354;CCL2_8218 59.88446666666666 57.8774 3.572988713015347 39.74636666666667 39.4215 1.2542611583451135 116.16766666666666 109.049 14.49985990736934 57.7663;57.8774;64.0097 38.6865;39.4215;41.1311 109.049;106.603;132.851 0 Exp 2,3(1) 1.5572580425847802 4.672486662864685 1.5230457782745361 1.589477300643921 0.03328445836832998 1.559963583946228 55.84124931593596 63.92768401739736 38.327036552553515 41.16569678077982 99.75953054603295 132.57580278730038 DOWN 0.0 1.0 0.0 GO:0061045 7 negative regulation of wound healing 33 35 3 3 2 3 2 2 67 33 2445 0.9328 0.24469 0.24469 5.71 24367;114851 fgg;cdkn1a FGG_8639;CDKN1A_8271 73.8651 73.8651 54.5478 27.318787648429804 62.43491576391484 22.023122740390335 44.818349999999995 44.818349999999995 38.2987 9.220177451925785 40.96062657825924 7.43287375432313 210.92405 210.92405 94.4701 164.69075548191827 142.0174169032499 132.76594733494247 0.5 73.8651 93.1824;54.5478 51.338;38.2987 327.378;94.4701 0 2 0 2 24367;114851 FGG_8639;CDKN1A_8271 73.8651 73.8651 27.318787648429804 44.818349999999995 44.818349999999995 9.220177451925785 210.92405 210.92405 164.69075548191827 93.1824;54.5478 51.338;38.2987 327.378;94.4701 0 Exp 2,1(0.5);Linear,1(0.5) 1.782539132582852 3.573442578315735 1.6645443439483643 1.9088982343673706 0.17278429292459394 1.7867212891578674 36.003192 111.727008 32.039835999999994 57.596864 -17.325691999999975 439.17379199999993 DOWN 0.0 1.0 0.0 GO:0045638 7 negative regulation of myeloid cell differentiation 29 31 2 2 2 2 2 2 67 29 2449 0.95021 0.20433 0.20433 6.45 360918;29339 pf4;apcs PF4_32963;APCS_8057 103.887 103.887 101.954 2.7336748160668205 102.74257523575234 2.203080097943939 56.17535 56.17535 53.8521 3.2855716587833004 57.55082068470684 2.6478560980583623 252.748 252.748 109.875 202.05293429693123 337.33537679376786 162.83531445082286 0.5 103.887 105.82;101.954 53.8521;58.4986 109.875;395.621 0 2 0 2 360918;29339 PF4_32963;APCS_8057 103.887 103.887 2.7336748160668205 56.17535 56.17535 3.2855716587833004 252.748 252.748 202.05293429693123 105.82;101.954 53.8521;58.4986 109.875;395.621 0 Exp 3,1(0.5);Linear,1(0.5) 1.7288161388090577 3.4643317461013794 1.6244933605194092 1.8398383855819702 0.15227192751652394 1.7321658730506897 100.09832 107.67568 51.62178 60.72892 -27.283079999999984 532.77908 DOWN 0.0 1.0 0.0 GO:0015850 6 organic hydroxy compound transport 49 50 2 2 2 2 2 2 67 48 2430 0.84811 0.39522 0.39522 4.0 24777;25649 slc10a1;apoa2 SLC10A1_9832;APOA2_33095 44.07531 44.07531 7.96762 51.06398490396339 56.813937508130714 47.78059535721998 28.186525 28.186525 6.07525 31.270064986361163 35.987281458107475 29.259414922616614 104.32365 104.32365 11.4863 131.29183946477787 137.07624149759948 122.84983764917138 7.96762;80.183 6.07525;50.2978 11.4863;197.161 1 1 1 25649 APOA2_33095 80.183 80.183 50.2978 50.2978 197.161 197.161 80.183 50.2978 197.161 1 24777 SLC10A1_9832 7.96762 7.96762 6.07525 6.07525 11.4863 11.4863 7.96762 6.07525 11.4863 0 Linear,1(0.5);Poly 2,1(0.5) 2.1989541469906277 4.424206018447876 1.9712703227996826 2.4529356956481934 0.3405888514039287 2.212103009223938 -26.695762400000007 114.84638240000001 -15.151574000000004 71.52462400000002 -77.637556 286.284856 CONFLICT 0.5 0.5 0.0 GO:2000147 6 positive regulation of cell motility 188 196 9 9 7 5 5 5 64 191 2287 0.55909 0.62359 1.0 2.55 24825;314654;24516;24770;287562 tf;myo1f;jun;ccl2;ccl12 TF_10003;MYO1F_32715;JUN_8938;CCL2_8218;CCL12_8217 58.1349 57.7663 25.5289 23.911152192543923 50.27519462708633 25.25844727738123 38.30422 38.6865 13.9582 16.769336869029736 32.60473088355445 18.19543257007255 155.09844 110.707 86.0232 102.95081347550392 193.0858373652881 124.76753544568744 51.412;91.9576;57.7663;64.0097;25.5289 36.6131;61.1322;38.6865;41.1311;13.9582 86.0232;110.707;109.049;132.851;336.862 2 3 2 24825;314654 TF_10003;MYO1F_32715 71.6848 71.6848 28.670068707277284 48.87265 48.87265 17.337621878591072 98.3651 98.3651 17.454082365452518 51.412;91.9576 36.6131;61.1322 86.0232;110.707 3 24516;24770;287562 JUN_8938;CCL2_8218;CCL12_8217 49.101633333333325 57.7663 20.651884381172934 31.2586 38.6865 15.032361671074838 192.92066666666668 132.851 125.22365743873375 57.7663;64.0097;25.5289 38.6865;41.1311;13.9582 109.049;132.851;336.862 0 Exp 2,2(0.4);Linear,1(0.2);Poly 2,2(0.4) 1.6318701178142152 8.205728769302368 1.5230457782745361 2.0048909187316895 0.20486558967109317 1.559963583946228 37.175851004634396 79.09394899536561 23.605248146716363 53.00319185328364 64.85807323010978 245.33880676989025 DOWN 0.4 0.6 0.0 GO:0007026 8 negative regulation of microtubule depolymerization 9 10 1 1 1 1 1 1 68 9 2469 0.97171 0.24053 0.24053 10.0 306575 ckap2 CKAP2_8324 12.1218 12.1218 12.1218 12.1218 8.47044 8.47044 8.47044 8.47044 21.3803 21.3803 21.3803 21.3803 0.0 12.1218 0.0 12.1218 12.1218 8.47044 21.3803 1 0 1 306575 CKAP2_8324 12.1218 12.1218 8.47044 8.47044 21.3803 21.3803 12.1218 8.47044 21.3803 0 0 Poly 2,1(1) 2.1833057403564453 2.1833057403564453 2.1833057403564453 2.1833057403564453 0.0 2.1833057403564453 12.1218 12.1218 8.47044 8.47044 21.3803 21.3803 UP 1.0 0.0 0.0 GO:0007162 6 negative regulation of cell adhesion 83 86 4 4 3 3 3 3 66 83 2395 0.79769 0.41442 0.50488 3.49 29692;314654;24367 pla2g2a;myo1f;fgg PLA2G2A_32641;MYO1F_32715;FGG_8639 61.71333333333373 91.9576 1.16694E-12 53.448822878462536 63.49296138463374 52.485435720436506 37.490066666667055 51.338 1.16694E-12 32.83459170468379 39.497316547772556 32.99952251722762 146.02833333333373 110.707 1.16694E-12 166.52262958028604 131.45204432230182 152.01940948945165 1.16694E-12;91.9576;93.1824 1.16694E-12;61.1322;51.338 1.16694E-12;110.707;327.378 1 2 1 314654 MYO1F_32715 91.9576 91.9576 61.1322 61.1322 110.707 110.707 91.9576 61.1322 110.707 2 29692;24367 PLA2G2A_32641;FGG_8639 46.59120000000058 46.59120000000058 65.88990692723652 25.669000000000583 25.669000000000583 36.301447932554154 163.6890000000006 163.6890000000006 231.4912038112887 1.16694E-12;93.1824 1.16694E-12;51.338 1.16694E-12;327.378 0 Exp 2,1(0.34);Hill,1(0.34);Poly 2,1(0.34) 1.819254297355865 5.483620524406433 1.5863633155822754 1.988358974456787 0.21289406317275053 1.9088982343673706 1.2302964709057136 122.19637019576173 0.3342283621830049 74.64590497115111 -42.40976129477758 334.466427961445 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0006928 3 movement of cell or subcellular component 248 268 9 9 9 8 8 8 61 260 2218 0.70207 0.4424 0.69265 2.99 360918;314654;290350;293502;303575;24770;287562;289054 pf4;myo1f;loxl2;kif22;kif18b;ccl2;ccl12;aspm PF4_32963;MYO1F_32715;LOXL2_9150;KIF22_8963;KIF18B_32882;CCL2_8218;CCL12_8217;ASPM_8092 47.499874999999996 44.7693 3.6768 39.51733780397626 44.13628894336632 34.275712887794256 28.929691249999998 27.54465 1.12034 23.548573863075593 27.4049073192214 21.739127797200588 109.21676250000002 110.291 11.7489 105.45100245453115 154.9947053169314 130.35903068893313 105.82;91.9576;65.4434;13.2391;3.6768;64.0097;25.5289;10.3235 53.8521;61.1322;43.7615;9.02099;1.12034;41.1311;13.9582;7.4611 109.875;110.707;129.393;25.4349;11.7489;132.851;336.862;16.8623 4 4 4 314654;293502;303575;289054 MYO1F_32715;KIF22_8963;KIF18B_32882;ASPM_8092 29.79925 11.7813 41.63166373010652 19.6836575 8.241045 27.842783757115445 41.188275 21.148600000000002 46.688513254002494 91.9576;13.2391;3.6768;10.3235 61.1322;9.02099;1.12034;7.4611 110.707;25.4349;11.7489;16.8623 4 360918;290350;24770;287562 PF4_32963;LOXL2_9150;CCL2_8218;CCL12_8217 65.2005 64.72655 32.78849712861711 38.175725 42.4463 17.050634142728146 177.24525 131.122 106.89082394161191 105.82;65.4434;64.0097;25.5289 53.8521;43.7615;41.1311;13.9582 109.875;129.393;132.851;336.862 0 Exp 2,1(0.13);Exp 3,1(0.13);Exp 4,1(0.13);Linear,1(0.13);Poly 2,4(0.5) 1.6560372708436681 13.28604543209076 1.5314651727676392 1.8689792156219482 0.13573528107536917 1.6015847325325012 20.1157570150815 74.8839929849185 12.611362109464022 45.248020390535984 36.14294595985213 182.29057904014786 CONFLICT 0.5 0.5 0.0 GO:0006281 6 DNA repair 69 74 2 2 2 2 2 2 67 72 2406 0.67551 0.60294 1.0 2.7 360847;293502 ube2t;kif22 UBE2T_10125;KIF22_8963 12.11525 12.11525 10.9914 1.5893639120730165 11.84462391304348 1.5425954385765468 8.44345 8.44345 7.86591 0.816764900812939 8.304376822742476 0.7927308534016997 21.8204 21.8204 18.2059 5.111674921197561 20.950018729096993 4.961259254113055 10.9914;13.2391 7.86591;9.02099 18.2059;25.4349 2 0 2 360847;293502 UBE2T_10125;KIF22_8963 12.11525 12.11525 1.5893639120730165 8.44345 8.44345 0.816764900812939 21.8204 21.8204 5.111674921197561 10.9914;13.2391 7.86591;9.02099 18.2059;25.4349 0 0 Poly 2,2(1) 1.9547927635618438 3.980240225791931 1.616806149482727 2.363434076309204 0.5279456700822553 1.9901201128959656 9.912504 14.317995999999999 7.311471600000001 9.5754284 14.735980000000001 28.904819999999997 UP 1.0 0.0 0.0 GO:0030154 4 cell differentiation 405 432 19 18 16 15 13 13 56 419 2059 0.72788 0.38569 0.62787 3.01 360243;24825;78968;362282;366960;290350;24516;362376;116663;170568;29680;58919;282840 top2a;tf;srebf1;pck1;maff;loxl2;jun;herc6;dusp6;dmbt1;cyp11a1;ccnd1;atf5 TOP2A_10059;TF_10003;SREBF1_32750;PCK1_9439;MAFF_9172;LOXL2_9150;JUN_8938;HERC6_8794;DUSP6_8506;DMBT1_32993;CYP11A1_32785;CCND1_8224;ATF5_8097 42.64196692307692 45.5478 5.51457 25.97422895475866 51.11345165734506 25.088144104224366 29.854199230769233 33.4848 1.34064 19.906548096973207 36.225605278751615 19.476759273887758 82.21354615384615 86.0232 24.5771 42.221295590981406 93.83046757708676 38.205441813002835 13.8391;51.412;11.2357;5.51457;58.0695;65.4434;57.7663;53.833;45.5478;21.7434;43.719;28.2655;97.9563 9.31624;36.6131;4.94421;1.34064;40.1293;43.7615;38.6865;36.3389;33.3115;12.6557;33.4848;22.3101;75.2121 27.6952;86.0232;24.5771;39.6721;104.733;129.393;109.049;98.3689;71.7388;160.485;63.9031;38.3337;114.804 8 5 8 360243;24825;78968;362282;366960;170568;29680;58919 TOP2A_10059;TF_10003;SREBF1_32750;PCK1_9439;MAFF_9172;DMBT1_32993;CYP11A1_32785;CCND1_8224 29.224846250000002 25.00445 19.689607439879058 20.09926125 17.4829 15.17145524211875 68.17779999999999 51.7876 46.960074775859205 13.8391;51.412;11.2357;5.51457;58.0695;21.7434;43.719;28.2655 9.31624;36.6131;4.94421;1.34064;40.1293;12.6557;33.4848;22.3101 27.6952;86.0232;24.5771;39.6721;104.733;160.485;63.9031;38.3337 5 290350;24516;362376;116663;282840 LOXL2_9150;JUN_8938;HERC6_8794;DUSP6_8506;ATF5_8097 64.10936 57.7663 20.234651620005742 45.46210000000001 38.6865 17.064093546977496 104.67074 109.049 21.548016833991923 65.4434;57.7663;53.833;45.5478;97.9563 43.7615;38.6865;36.3389;33.3115;75.2121 129.393;109.049;98.3689;71.7388;114.804 0 Exp 2,3(0.24);Hill,2(0.16);Linear,5(0.39);Poly 2,3(0.24) 1.90669876904012 25.266368627548218 1.5089621543884277 2.857419490814209 0.4104964544675082 1.8216042518615723 28.522215223033346 56.761718623120515 19.032876417922388 40.67552204361607 59.26178842362937 105.16530388406291 UP 0.6153846153846154 0.38461538461538464 0.0 GO:0071222 6 cellular response to lipopolysaccharide 81 86 5 5 5 5 5 5 64 81 2397 0.97285 0.081066 0.081066 5.81 360918;24516;24450;29680;24770 pf4;jun;hmgcs2;cyp11a1;ccl2 PF4_32963;JUN_8938;HMGCS2_8812;CYP11A1_32785;CCL2_8218 60.3827 57.7663 30.5985 28.501431440280328 53.23690644208685 25.222494031570665 38.3463 38.6865 24.577 10.741607019668885 35.36175798971892 10.344772964644603 91.24874 109.049 40.5656 37.78590862355966 84.77400001093733 40.43357807488809 3.5 84.91485 105.82;57.7663;30.5985;43.719;64.0097 53.8521;38.6865;24.577;33.4848;41.1311 109.875;109.049;40.5656;63.9031;132.851 2 3 2 24450;29680 HMGCS2_8812;CYP11A1_32785 37.15875 37.15875 9.277594522558136 29.030900000000003 29.030900000000003 6.298765785453517 52.234350000000006 52.234350000000006 16.502104505941027 30.5985;43.719 24.577;33.4848 40.5656;63.9031 3 360918;24516;24770 PF4_32963;JUN_8938;CCL2_8218 75.86533333333334 64.0097 26.128653854022627 44.55656666666667 41.1311 8.142433435609592 117.25833333333333 109.875 13.509959634778216 105.82;57.7663;64.0097 53.8521;38.6865;41.1311 109.875;109.049;132.851 0 Exp 2,4(0.8);Exp 3,1(0.2) 1.915838378518281 10.044319868087769 1.5230457782745361 3.3687045574188232 0.771500536800994 1.752767562866211 35.40009384264551 85.3653061573545 28.930866314441126 47.76173368555887 58.12793077264104 124.36954922735896 DOWN 0.4 0.6 0.0 GO:0031110 7 regulation of microtubule polymerization or depolymerization 24 26 2 2 2 2 2 2 67 24 2454 0.96831 0.15528 0.15528 7.69 291441;306575 ska1;ckap2 SKA1_9829;CKAP2_8324 12.0212 12.0212 11.9206 0.1422698843745472 11.98371381794368 0.13202383235483747 8.409375 8.409375 8.34831 0.08635895118608913 8.386620589390962 0.08013951613096751 21.2143 21.2143 21.0483 0.23475945135346712 21.15244407334643 0.21785244702726345 0.5 12.0212 11.9206;12.1218 8.34831;8.47044 21.0483;21.3803 2 0 2 291441;306575 SKA1_9829;CKAP2_8324 12.0212 12.0212 0.1422698843745472 8.409375 8.409375 0.08635895118608913 21.2143 21.2143 0.23475945135346712 11.9206;12.1218 8.34831;8.47044 21.0483;21.3803 0 0 Poly 2,2(1) 1.9968539567689492 4.0096306800842285 1.8263249397277832 2.1833057403564453 0.25242354487792995 2.0048153400421143 11.824024 12.218376000000001 8.2896876 8.5290624 20.888940000000005 21.539659999999998 UP 1.0 0.0 0.0 GO:0042060 5 wound healing 52 55 2 2 2 2 2 2 67 53 2425 0.81464 0.4428 0.65998 3.64 84032;81639 col3a1;alox15 COL3A1_8354;ALOX15_8036 81.7507 81.7507 57.8774 33.76194463860161 97.9666970577093 24.77805046061393 61.62585 61.62585 39.4215 31.401692913679053 76.70820871322137 23.045850583921453 118.0215 118.0215 106.603 16.1481975619571 125.77754388180324 11.85123837862922 57.8774;105.624 39.4215;83.8302 106.603;129.44 1 1 1 81639 ALOX15_8036 105.624 105.624 83.8302 83.8302 129.44 129.44 105.624 83.8302 129.44 1 84032 COL3A1_8354 57.8774 57.8774 39.4215 39.4215 106.603 106.603 57.8774 39.4215 106.603 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.6396728528230209 3.2809308767318726 1.589477300643921 1.6914535760879517 0.07210811588662136 1.6404654383659363 34.95903200000001 128.54236799999998 18.105324000000003 105.146376 95.64124 140.40176 CONFLICT 0.5 0.5 0.0 GO:0071549 7 cellular response to dexamethasone stimulus 35 36 3 3 3 3 3 3 66 33 2445 0.98488 0.07193 0.07193 8.33 362282;79438;24770 pck1;igfals;ccl2 PCK1_9439;IGFALS_8880;CCL2_8218 46.63019 64.0097 5.51457 35.74873769629216 60.4696630290993 25.90910319515569 29.50588 41.1311 1.34064 24.515288555372962 39.08560835842957 17.834297842798282 107.10636666666666 132.851 39.6721 58.94146245982816 130.78312837875288 43.408237218430635 0.5 34.762135 5.51457;70.3663;64.0097 1.34064;46.0459;41.1311 39.6721;148.796;132.851 1 2 1 362282 PCK1_9439 5.51457 5.51457 1.34064 1.34064 39.6721 39.6721 5.51457 1.34064 39.6721 2 79438;24770 IGFALS_8880;CCL2_8218 67.18799999999999 67.18799999999999 4.49479496529079 43.5885 43.5885 3.475288408175687 140.8235 140.8235 11.274817626019253 70.3663;64.0097 46.0459;41.1311 148.796;132.851 0 Exp 2,1(0.34);Hill,1(0.34);Linear,1(0.34) 1.7745199840196064 5.432443976402283 1.527578592300415 2.3449018001556396 0.4628163813451772 1.559963583946228 6.176685068998545 87.08369493100145 1.76421944445638 57.24754055554362 40.40782300014712 173.8049103331862 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0006639 6 acylglycerol metabolic process 23 26 4 4 2 4 2 2 67 24 2454 0.96831 0.15528 0.15528 7.69 25086;25649 cyp2e1;apoa2 CYP2E1_8421;APOA2_33095 64.86795000000001 64.86795000000001 49.5529 21.658751418422028 72.85290204650353 18.481953214827676 38.647850000000005 38.647850000000005 26.9979 16.47551729096842 44.7218942959157 14.058970153873572 134.37935 134.37935 71.5977 88.78666089816087 167.11241092049116 75.76387397035505 0.5 64.86795000000001 49.5529;80.183 26.9979;50.2978 71.5977;197.161 2 0 2 25086;25649 CYP2E1_8421;APOA2_33095 64.86795000000001 64.86795000000001 21.658751418422028 38.647850000000005 38.647850000000005 16.47551729096842 134.37935 134.37935 88.78666089816087 49.5529;80.183 26.9979;50.2978 71.5977;197.161 0 0 Linear,1(0.5);Poly 2,1(0.5) 2.0841850269736693 4.174837827682495 1.9712703227996826 2.2035675048828125 0.1642589127015073 2.0874189138412476 34.850452000000004 94.88544800000001 15.813948000000003 61.48175200000001 11.32731600000001 257.431384 UP 1.0 0.0 0.0 GO:0042391 4 regulation of membrane potential 94 95 3 3 3 3 3 3 66 92 2386 0.74496 0.47958 0.74206 3.16 287877;24516;81639 pycr1;jun;alox15 PYCR1_9631;JUN_8938;ALOX15_8036 72.70083333333334 57.7663 54.7122 28.55316198292816 73.43108296940927 29.014460605670212 53.63410000000001 38.6865 38.3856 26.15102247733343 54.407576661392405 26.482881479281705 111.13976666666667 109.049 94.9303 17.34959156474091 111.03042107594938 17.952935104017257 54.7122;57.7663;105.624 38.3856;38.6865;83.8302 94.9303;109.049;129.44 2 1 2 287877;81639 PYCR1_9631;ALOX15_8036 80.1681 80.1681 36.00007902241325 61.1079 61.1079 32.1341848283102 112.18515 112.18515 24.402042886713403 54.7122;105.624 38.3856;83.8302 94.9303;129.44 1 24516 JUN_8938 57.7663 57.7663 38.6865 38.6865 109.049 109.049 57.7663 38.6865 109.049 0 Exp 2,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 1.6231958920735114 4.87462043762207 1.5230457782745361 1.6914535760879517 0.0895661307898132 1.6601210832595825 40.38988884949857 105.01177781716811 24.041432260930044 83.22676773906997 91.50685560060941 130.77267773272393 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0000122 9 negative regulation of transcription by RNA polymerase II 174 180 7 7 6 7 6 6 63 174 2304 0.78846 0.36096 0.62992 3.33 78968;114519;290350;24516;299691;58919 srebf1;nfil3;loxl2;jun;cry1;ccnd1 SREBF1_32750;NFIL3_9304;LOXL2_9150;JUN_8938;CRY1_8386;CCND1_8224 38.84676666666667 35.18485 11.2357 19.874871100529592 42.8237709763586 17.768391859127657 26.197518333333335 23.95655 4.94421 13.786075548335596 28.699596915259438 11.968917247712444 70.30161666666667 60.22845 24.5771 41.661746424431925 78.6420018882407 39.40567779195756 11.2357;33.1149;65.4434;57.7663;37.2548;28.2655 4.94421;25.603;43.7615;38.6865;21.8798;22.3101 24.5771;46.6318;129.393;109.049;73.8251;38.3337 2 4 2 78968;58919 SREBF1_32750;CCND1_8224 19.7506 19.7506 12.04188706225067 13.627154999999998 13.627154999999998 12.279538580339652 31.4554 31.4554 9.727385146070851 11.2357;28.2655 4.94421;22.3101 24.5771;38.3337 4 114519;290350;24516;299691 NFIL3_9304;LOXL2_9150;JUN_8938;CRY1_8386 48.39485 47.51055 15.663702395559826 32.482699999999994 32.14475 10.415536862143362 89.724725 91.43705 36.77316914068145 33.1149;65.4434;57.7663;37.2548 25.603;43.7615;38.6865;21.8798 46.6318;129.393;109.049;73.8251 0 Exp 2,2(0.34);Hill,1(0.17);Linear,3(0.5) 2.1190173444328804 13.083168983459473 1.5230457782745361 2.857419490814209 0.5700523982925693 2.0649070739746094 22.943557652704207 54.74997568062913 15.16636045469854 37.22867621196813 36.9652766258606 103.63795670747272 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0009967 6 positive regulation of signal transduction 363 381 13 13 11 10 10 10 59 371 2107 0.53945 0.59681 1.0 2.62 24825;29692;24516;24367;84032;24770;287562;289054;29657;81639 tf;pla2g2a;jun;fgg;col3a1;ccl2;ccl12;aspm;arntl;alox15 TF_10003;PLA2G2A_32641;JUN_8938;FGG_8639;COL3A1_8354;CCL2_8218;CCL12_8217;ASPM_8092;ARNTL_8086;ALOX15_8036 50.394190000000116 54.589150000000004 1.16694E-12 33.482518578918956 50.06339508454766 32.88832205407459 33.956330000000115 37.6498 1.16694E-12 24.04150269402413 34.65491319481928 25.811568598146856 130.82719000000012 107.826 1.16694E-12 114.90760016307243 151.8189647755892 122.10874757204542 51.412;1.16694E-12;57.7663;93.1824;57.8774;64.0097;25.5289;10.3235;38.2177;105.624 36.6131;1.16694E-12;38.6865;51.338;39.4215;41.1311;13.9582;7.4611;27.1236;83.8302 86.0232;1.16694E-12;109.049;327.378;106.603;132.851;336.862;16.8623;63.2034;129.44 3 7 3 24825;289054;81639 TF_10003;ASPM_8092;ALOX15_8036 55.7865 51.412 47.80061205413587 42.634800000000006 36.6131 38.53901285541705 77.44183333333334 86.0232 56.777324036302836 51.412;10.3235;105.624 36.6131;7.4611;83.8302 86.0232;16.8623;129.44 7 29692;24516;24367;84032;24770;287562;29657 PLA2G2A_32641;JUN_8938;FGG_8639;COL3A1_8354;CCL2_8218;CCL12_8217;ARNTL_8086 48.08320000000016 57.7663 29.98693794282185 30.236985714285883 38.6865 17.835598599002783 153.70662857142875 109.049 129.21055829084682 1.16694E-12;57.7663;93.1824;57.8774;64.0097;25.5289;38.2177 1.16694E-12;38.6865;51.338;39.4215;41.1311;13.9582;27.1236 1.16694E-12;109.049;327.378;106.603;132.851;336.862;63.2034 0 Exp 2,4(0.4);Hill,1(0.1);Linear,1(0.1);Poly 2,3(0.3);Power,1(0.1) 1.8839807478439867 20.239939332008362 1.5230457782745361 4.897102355957031 1.0277831124167616 1.6404654383659363 29.641509980375645 71.1468700196246 19.055252250306808 48.85740774969344 59.60672155206822 202.047658447932 DOWN 0.3 0.7 0.0 GO:0045859 7 regulation of protein kinase activity 207 223 7 7 7 6 6 6 63 217 2261 0.5996 0.57076 1.0 2.69 24825;361921;116663;498709;114851;58919 tf;ect2;dusp6;cks2;cdkn1a;ccnd1 TF_10003;ECT2_8523;DUSP6_8506;CKS2_8325;CDKN1A_8271;CCND1_8224 34.767833333333336 36.90665 14.4142 18.193846792217055 39.369464230948324 16.709002284520018 24.958225 27.8108 9.59235 13.129013612139715 28.3714022349837 11.780759113180055 58.28948333333333 55.036249999999995 29.0958 29.344930592892315 65.11040886233121 28.469172834751625 51.412;14.4142;45.5478;14.4197;54.5478;28.2655 36.6131;9.59235;33.3115;9.6236;38.2987;22.3101 86.0232;30.0753;71.7388;29.0958;94.4701;38.3337 4 2 4 24825;361921;498709;58919 TF_10003;ECT2_8523;CKS2_8325;CCND1_8224 27.127850000000002 21.3426 17.456117948444312 19.5347875 15.966849999999999 12.86409497298424 45.882 34.204499999999996 27.07964208072183 51.412;14.4142;14.4197;28.2655 36.6131;9.59235;9.6236;22.3101 86.0232;30.0753;29.0958;38.3337 2 116663;114851 DUSP6_8506;CDKN1A_8271 50.0478 50.0478 6.363961030678928 35.805099999999996 35.805099999999996 3.526482939133565 83.10445 83.10445 16.073456375185824 45.5478;54.5478 33.3115;38.2987 71.7388;94.4701 0 Linear,4(0.67);Poly 2,2(0.34) 1.784701179266339 10.814924240112305 1.530501127243042 2.2675669193267822 0.2849337036212814 1.7221581935882568 20.209723907560598 49.32594275910607 14.452826169239657 35.46362383076034 34.8086485466085 81.77031812005816 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0051591 5 response to cAMP 57 59 6 6 6 6 6 6 63 53 2425 0.99912 0.0046109 0.0046109 10.17 24825;78968;362282;24516;24450;29680 tf;srebf1;pck1;jun;hmgcs2;cyp11a1 TF_10003;SREBF1_32750;PCK1_9439;JUN_8938;HMGCS2_8812;CYP11A1_32785 33.374345 37.15875 5.51457 21.453803087754633 39.42969415315315 18.613040002209193 23.274375000000003 29.030900000000003 1.34064 16.361469812886316 28.034933220009485 13.250008732633287 60.63168333333334 52.234350000000006 24.5771 32.06728130674107 67.68661621621622 33.715671350683124 1.5 20.9171 4.5 54.589150000000004 51.412;11.2357;5.51457;57.7663;30.5985;43.719 36.6131;4.94421;1.34064;38.6865;24.577;33.4848 86.0232;24.5771;39.6721;109.049;40.5656;63.9031 5 1 5 24825;78968;362282;24450;29680 TF_10003;SREBF1_32750;PCK1_9439;HMGCS2_8812;CYP11A1_32785 28.495954 30.5985 19.92088961476319 20.191950000000002 24.577 16.228433040278414 50.948220000000006 40.5656 24.127105028307884 51.412;11.2357;5.51457;30.5985;43.719 36.6131;4.94421;1.34064;24.577;33.4848 86.0232;24.5771;39.6721;40.5656;63.9031 1 24516 JUN_8938 57.7663 57.7663 38.6865 38.6865 109.049 109.049 57.7663 38.6865 109.049 0 Exp 2,3(0.5);Hill,2(0.34);Linear,1(0.17) 2.2233863583316236 13.851730108261108 1.5230457782745361 3.3687045574188232 0.6992319591546906 2.1748963594436646 16.207727268332626 50.540962731667385 10.182472522049608 36.3662774779504 34.972514297663686 86.290852369003 UP 0.8333333333333334 0.16666666666666666 0.0 GO:0043933 5 protein-containing complex subunit organization 226 259 8 8 8 7 7 7 62 252 2226 0.59646 0.56287 1.0 2.7 25044;360918;303575;24367;361921;25649;29339 sds;pf4;kif18b;fgg;ect2;apoa2;apcs SDS_9798;PF4_32963;KIF18B_32882;FGG_8639;ECT2_8523;APOA2_33095;APCS_8057 66.28139999999999 80.183 3.6768 41.562550662184684 70.27182771707166 37.3819280128941 38.30358428571429 50.2978 1.12034 23.081446200821023 41.86095944528711 21.337649333745137 171.24102857142856 126.828 11.7489 145.20145712818817 200.06536846618167 146.96121160971438 64.7394;105.82;3.6768;93.1824;14.4142;80.183;101.954 43.4259;53.8521;1.12034;51.338;9.59235;50.2978;58.4986 126.828;109.875;11.7489;327.378;30.0753;197.161;395.621 3 4 3 303575;361921;25649 KIF18B_32882;ECT2_8523;APOA2_33095 32.758 14.4142 41.420657991393625 20.336830000000003 9.59235 26.290464637691365 79.66173333333333 30.0753 102.16908771562626 3.6768;14.4142;80.183 1.12034;9.59235;50.2978 11.7489;30.0753;197.161 4 25044;360918;24367;29339 SDS_9798;PF4_32963;FGG_8639;APCS_8057 91.42395 97.56819999999999 18.558785553927397 51.778650000000006 52.59505 6.309239993586047 239.9255 227.103 143.2866655031095 64.7394;105.82;93.1824;101.954 43.4259;53.8521;51.338;58.4986 126.828;109.875;327.378;395.621 0 Exp 2,1(0.15);Exp 3,1(0.15);Exp 4,1(0.15);Linear,3(0.43);Poly 2,1(0.15) 1.841277184163801 12.911208152770996 1.6244933605194092 1.9712703227996826 0.11462060484098151 1.8689792156219482 35.4914315864142 97.07136841358579 21.204609652529356 55.40255891889922 63.67428381311865 278.80777332973844 CONFLICT 0.42857142857142855 0.5714285714285714 0.0 GO:0009987 2 cellular process 2111 2325 82 79 73 70 62 62 7 2263 215 0.39578 0.75059 0.66309 2.67 29142;360847;360243;24825;78968;29503;24777;291441;25044;83792;287877;29692;360918;362282;338475;114519;24587;299923;314654;286918;366960;290350;287167;304477;293502;303575;24516;79438;24450;85430;362376;24440;360504;316033;81660;24367;171142;361921;29740;116663;170568;24306;25086;499353;29680;299691;84032;498709;306575;114851;297594;58919;24770;287562;791259;282840;289054;25612;29657;25649;29339;81639 vnn1;ube2t;top2a;tf;srebf1;slc22a2;slc10a1;ska1;sds;scd2;pycr1;pla2g2a;pf4;pck1;nrep;nfil3;nefh;ndrg1;myo1f;mx2;maff;loxl2;hba-a1;kntc1;kif22;kif18b;jun;igfals;hmgcs2;herpud1;herc6;hbb;hba-a2;glb1;gatm;fgg;ehhadh;ect2;eci1;dusp6;dmbt1;cyp4a2;cyp2e1;cyp2c24;cyp11a1;cry1;col3a1;cks2;ckap2;cdkn1a;cdca3;ccnd1;ccl2;ccl12;car14;atf5;aspm;asns;arntl;apoa2;apcs;alox15 VNN1_10157;UBE2T_10125;TOP2A_10059;TF_10003;SREBF1_32750;SLC22A2_9845;SLC10A1_9832;SKA1_9829;SDS_9798;SCD_9786;PYCR1_9631;PLA2G2A_32641;PF4_32963;PCK1_9439;NREP_9364;NFIL3_9304;NEFH_33218;NDRG1_32364;MYO1F_32715;MX2_9268;MAFF_9172;LOXL2_9150;LOC287167_9118;KNTC1_8976;KIF22_8963;KIF18B_32882;JUN_8938;IGFALS_8880;HMGCS2_8812;HERPUD1_8795;HERC6_8794;HBB_8782;HBA2_32600;GLB1_8712;GATM_32792;FGG_8639;EHHADH_8534;ECT2_8523;ECI1_8520;DUSP6_8506;DMBT1_32993;CYP4A2_8425;CYP2E1_8421;CYP2C24_32875;CYP11A1_32785;CRY1_8386;COL3A1_8354;CKS2_8325;CKAP2_8324;CDKN1A_8271;CDCA3_8260;CCND1_8224;CCL2_8218;CCL12_8217;CAR14_8195;ATF5_8097;ASPM_8092;ASNS_8091;ARNTL_8086;APOA2_33095;APCS_8057;ALOX15_8036 50.04094161290324 50.48245 1.16694E-12 33.41047658314604 52.34490146008437 31.51747639015385 32.729369403225824 34.91185 1.16694E-12 21.789487956512197 33.988066977492096 20.125047249492134 101.97584951612906 93.56275 1.16694E-12 90.73444500884469 114.73490872795551 97.72821934587161 20.8684;10.9914;13.8391;51.412;11.2357;81.8219;7.96762;11.9206;64.7394;83.9984;54.7122;1.16694E-12;105.82;5.51457;36.861;33.1149;79.3182;99.6641;91.9576;31.6605;58.0695;65.4434;105.203;7.89839;13.2391;3.6768;57.7663;70.3663;30.5985;53.893;53.833;91.4283;101.406;65.9159;37.423;93.1824;32.6956;14.4142;103.231;45.5478;21.7434;59.5671;49.5529;10.5651;43.719;37.2548;57.8774;14.4197;12.1218;54.5478;2.6193;28.2655;64.0097;25.5289;98.1742;97.9563;10.3235;85.6642;38.2177;80.183;101.954;105.624 17.1194;7.86591;9.31624;36.6131;4.94421;46.3605;6.07525;8.34831;43.4259;54.1928;38.3856;1.16694E-12;53.8521;1.34064;28.0333;25.603;39.4261;42.5546;61.1322;23.5989;40.1293;43.7615;82.0435;3.83458;9.02099;1.12034;38.6865;46.0459;24.577;37.9512;36.3389;54.7263;84.6435;47.8573;28.03;51.338;25.6436;9.59235;49.9975;33.3115;12.6557;43.4174;26.9979;7.63639;33.4848;21.8798;39.4215;9.6236;8.47044;38.2987;0.978353;22.3101;41.1311;13.9582;55.9966;75.2121;7.4611;53.6991;27.1236;50.2978;58.4986;83.8302 26.5474;18.2059;27.6952;86.0232;24.5771;102.079;11.4863;21.0483;126.828;206.18;94.9303;1.16694E-12;109.875;39.6721;53.5645;46.6318;264.141;105.409;110.707;46.786;104.733;129.393;130.247;12.5679;25.4349;11.7489;109.049;148.796;40.5656;92.6554;98.3689;277.036;115.953;114.587;55.6613;327.378;45.0542;30.0753;107.244;71.7388;160.485;99.5908;71.5977;17.0471;63.9031;73.8251;106.603;29.0958;21.3803;94.4701;7.96997;38.3337;132.851;336.862;356.234;114.804;16.8623;224.488;63.2034;197.161;395.621;129.44 35 27 35 29142;360847;360243;24825;78968;29503;291441;83792;287877;362282;314654;366960;287167;304477;293502;303575;24450;85430;360504;316033;171142;361921;29740;170568;24306;25086;29680;498709;306575;297594;58919;289054;25612;25649;81639 VNN1_10157;UBE2T_10125;TOP2A_10059;TF_10003;SREBF1_32750;SLC22A2_9845;SKA1_9829;SCD_9786;PYCR1_9631;PCK1_9439;MYO1F_32715;MAFF_9172;LOC287167_9118;KNTC1_8976;KIF22_8963;KIF18B_32882;HMGCS2_8812;HERPUD1_8795;HBA2_32600;GLB1_8712;EHHADH_8534;ECT2_8523;ECI1_8520;DMBT1_32993;CYP4A2_8425;CYP2E1_8421;CYP11A1_32785;CKS2_8325;CKAP2_8324;CDCA3_8260;CCND1_8224;ASPM_8092;ASNS_8091;APOA2_33095;ALOX15_8036 44.06617885714285 32.6956 34.55527911957854 30.15018751428572 25.6436 24.61537797529496 75.68112485714285 63.9031 59.33443378925124 20.8684;10.9914;13.8391;51.412;11.2357;81.8219;11.9206;83.9984;54.7122;5.51457;91.9576;58.0695;105.203;7.89839;13.2391;3.6768;30.5985;53.893;101.406;65.9159;32.6956;14.4142;103.231;21.7434;59.5671;49.5529;43.719;14.4197;12.1218;2.6193;28.2655;10.3235;85.6642;80.183;105.624 17.1194;7.86591;9.31624;36.6131;4.94421;46.3605;8.34831;54.1928;38.3856;1.34064;61.1322;40.1293;82.0435;3.83458;9.02099;1.12034;24.577;37.9512;84.6435;47.8573;25.6436;9.59235;49.9975;12.6557;43.4174;26.9979;33.4848;9.6236;8.47044;0.978353;22.3101;7.4611;53.6991;50.2978;83.8302 26.5474;18.2059;27.6952;86.0232;24.5771;102.079;21.0483;206.18;94.9303;39.6721;110.707;104.733;130.247;12.5679;25.4349;11.7489;40.5656;92.6554;115.953;114.587;45.0542;30.0753;107.244;160.485;99.5908;71.5977;63.9031;29.0958;21.3803;7.96997;38.3337;16.8623;224.488;197.161;129.44 27 24777;25044;29692;360918;338475;114519;24587;299923;286918;290350;24516;79438;362376;24440;81660;24367;116663;499353;299691;84032;114851;24770;287562;791259;282840;29657;29339 SLC10A1_9832;SDS_9798;PLA2G2A_32641;PF4_32963;NREP_9364;NFIL3_9304;NEFH_33218;NDRG1_32364;MX2_9268;LOXL2_9150;JUN_8938;IGFALS_8880;HERC6_8794;HBB_8782;GATM_32792;FGG_8639;DUSP6_8506;CYP2C24_32875;CRY1_8386;COL3A1_8354;CDKN1A_8271;CCL2_8218;CCL12_8217;CAR14_8195;ATF5_8097;ARNTL_8086;APCS_8057 57.78600444444448 57.7663 30.77494195613707 36.072753333333374 38.6865 17.34921687988974 136.06160370370375 106.603 112.13461634229382 7.96762;64.7394;1.16694E-12;105.82;36.861;33.1149;79.3182;99.6641;31.6605;65.4434;57.7663;70.3663;53.833;91.4283;37.423;93.1824;45.5478;10.5651;37.2548;57.8774;54.5478;64.0097;25.5289;98.1742;97.9563;38.2177;101.954 6.07525;43.4259;1.16694E-12;53.8521;28.0333;25.603;39.4261;42.5546;23.5989;43.7615;38.6865;46.0459;36.3389;54.7263;28.03;51.338;33.3115;7.63639;21.8798;39.4215;38.2987;41.1311;13.9582;55.9966;75.2121;27.1236;58.4986 11.4863;126.828;1.16694E-12;109.875;53.5645;46.6318;264.141;105.409;46.786;129.393;109.049;148.796;98.3689;277.036;55.6613;327.378;71.7388;17.0471;73.8251;106.603;94.4701;132.851;336.862;356.234;114.804;63.2034;395.621 0 Exp 2,18(0.3);Exp 3,3(0.05);Exp 4,2(0.04);Exp 5,1(0.02);Hill,3(0.05);Linear,15(0.25);Poly 2,19(0.31);Power,1(0.02) 1.90208881222812 121.28085899353027 1.5089621543884277 4.897102355957031 0.5466879685056583 1.79746013879776 41.724397465278216 58.35748576052825 27.30552463724333 38.15321416920832 79.39020887887553 124.56149015338262 CONFLICT 0.5645161290322581 0.43548387096774194 0.0 GO:0043434 5 response to peptide hormone 194 204 10 10 9 9 8 8 61 196 2282 0.90397 0.18324 0.25857 3.92 78968;362282;79438;24450;81660;29680;299691;24770 srebf1;pck1;igfals;hmgcs2;gatm;cyp11a1;cry1;ccl2 SREBF1_32750;PCK1_9439;IGFALS_8880;HMGCS2_8812;GATM_32792;CYP11A1_32785;CRY1_8386;CCL2_8218 37.51519625 37.3389 5.51457 22.621765512875882 41.632776191916626 18.36944654725684 25.17918125 26.3035 1.34064 15.838347599918407 28.26666546542959 12.204744049715115 72.4814125 59.7822 24.5771 45.065992430987485 76.79232298423995 42.932944603180154 11.2357;5.51457;70.3663;30.5985;37.423;43.719;37.2548;64.0097 4.94421;1.34064;46.0459;24.577;28.03;33.4848;21.8798;41.1311 24.5771;39.6721;148.796;40.5656;55.6613;63.9031;73.8251;132.851 4 4 4 78968;362282;24450;29680 SREBF1_32750;PCK1_9439;HMGCS2_8812;CYP11A1_32785 22.7669425 20.9171 17.61567405117457 16.086662500000003 14.760605000000002 15.452944127447848 42.179475000000004 40.11885 16.23423348655035 11.2357;5.51457;30.5985;43.719 4.94421;1.34064;24.577;33.4848 24.5771;39.6721;40.5656;63.9031 4 79438;81660;299691;24770 IGFALS_8880;GATM_32792;CRY1_8386;CCL2_8218 52.26345 50.71635 17.427813959396428 34.2717 34.58055 11.227958533648641 102.78335 103.33805000000001 45.01960823096975 70.3663;37.423;37.2548;64.0097 46.0459;28.03;21.8798;41.1311 148.796;55.6613;73.8251;132.851 0 Exp 2,5(0.63);Hill,2(0.25);Linear,1(0.13) 2.1035137264821078 17.456923604011536 1.527578592300415 3.3687045574188232 0.6538541650846554 2.022794008255005 21.839112529364815 53.19127997063519 14.203766319121856 36.154596180878144 41.25227302812419 103.71055197187582 CONFLICT 0.5 0.5 0.0 GO:0030334 6 regulation of cell migration 259 272 10 10 7 6 5 5 64 267 2211 0.23722 0.87588 0.43265 1.84 314654;24516;84032;24770;287562 myo1f;jun;col3a1;ccl2;ccl12 MYO1F_32715;JUN_8938;COL3A1_8354;CCL2_8218;CCL12_8217 59.427980000000005 57.8774 25.5289 23.62986161146527 50.487503850554475 26.93149329471096 38.865899999999996 39.4215 13.9582 16.745548973831824 32.23621021827143 19.333831471337586 159.2144 110.707 106.603 99.86389896654349 208.2713655606408 123.13749678874665 91.9576;57.7663;57.8774;64.0097;25.5289 61.1322;38.6865;39.4215;41.1311;13.9582 110.707;109.049;106.603;132.851;336.862 1 4 1 314654 MYO1F_32715 91.9576 91.9576 61.1322 61.1322 110.707 110.707 91.9576 61.1322 110.707 4 24516;84032;24770;287562 JUN_8938;COL3A1_8354;CCL2_8218;CCL12_8217 51.295575 57.82185 17.42375024143289 33.299325 39.054 12.934688465872174 171.34125 120.95 110.98045390780908 57.7663;57.8774;64.0097;25.5289 38.6865;39.4215;41.1311;13.9582 109.049;106.603;132.851;336.862 0 Exp 2,3(0.6);Poly 2,2(0.4) 1.5578236979909101 7.7903151512146 1.5230457782745361 1.589477300643921 0.030516506177755382 1.559963583946228 38.71549307003757 80.14046692996243 24.1877791561924 53.54402084380761 71.67983309775406 246.74896690224597 DOWN 0.2 0.8 0.0 GO:0006869 6 lipid transport 73 76 4 4 3 4 3 3 66 73 2405 0.85153 0.33958 0.45972 3.95 24777;29692;25649 slc10a1;pla2g2a;apoa2 SLC10A1_9832;PLA2G2A_32641;APOA2_33095 29.38354000000039 7.96762 1.16694E-12 44.17363007875588 47.06191077485588 45.89944715769414 18.79101666666706 6.07525 1.16694E-12 27.454238518866468 29.81011884220674 28.426836312100416 69.5491000000004 11.4863 1.16694E-12 110.66427399178977 113.54731127004509 115.68764921739934 7.96762;1.16694E-12;80.183 6.07525;1.16694E-12;50.2978 11.4863;1.16694E-12;197.161 1 2 1 25649 APOA2_33095 80.183 80.183 50.2978 50.2978 197.161 197.161 80.183 50.2978 197.161 2 24777;29692 SLC10A1_9832;PLA2G2A_32641 3.9838100000005836 3.9838100000005836 5.633958131916735 3.0376250000005833 3.0376250000005833 4.295850472402748 5.7431500000005835 5.7431500000005835 8.122040620742215 7.96762;1.16694E-12 6.07525;1.16694E-12 11.4863;1.16694E-12 0 Hill,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 2.1263873513992477 6.412564992904663 1.9712703227996826 2.4529356956481934 0.2732901642606598 1.988358974456787 -20.603628145422814 79.37070814542359 -12.276378851889895 49.85841218522401 -55.67931482251488 194.77751482251568 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0065008 3 regulation of biological quality 821 880 31 29 26 26 22 22 47 858 1620 0.36981 0.72306 0.70124 2.5 24825;78968;287877;29692;362282;286918;58827;25087;24516;85430;81660;24367;499353;29680;299691;58919;24770;287562;289054;29657;25649;81639 tf;srebf1;pycr1;pla2g2a;pck1;mx2;mest;kng2l1;jun;herpud1;gatm;fgg;cyp2c24;cyp11a1;cry1;ccnd1;ccl2;ccl12;aspm;arntl;apoa2;alox15 TF_10003;SREBF1_32750;PYCR1_9631;PLA2G2A_32641;PCK1_9439;MX2_9268;MEST_9219;KNG2_8975;JUN_8938;HERPUD1_8795;GATM_32792;FGG_8639;CYP2C24_32875;CYP11A1_32785;CRY1_8386;CCND1_8224;CCL2_8218;CCL12_8217;ASPM_8092;ARNTL_8086;APOA2_33095;ALOX15_8036 45.97022590909096 40.96835 1.16694E-12 30.5505500534863 47.55825329109194 27.814234661478842 30.88177909090915 30.7574 1.16694E-12 20.88273789252068 32.42997101170703 19.73123438451477 109.89677727272733 79.92415 1.16694E-12 101.80420705851627 117.07425579957209 100.92360379779196 51.412;11.2357;54.7122;1.16694E-12;5.51457;31.6605;96.9172;73.9369;57.7663;53.893;37.423;93.1824;10.5651;43.719;37.2548;28.2655;64.0097;25.5289;10.3235;38.2177;80.183;105.624 36.6131;4.94421;38.3856;1.16694E-12;1.34064;23.5989;56.7353;52.6626;38.6865;37.9512;28.03;51.338;7.63639;33.4848;21.8798;22.3101;41.1311;13.9582;7.4611;27.1236;50.2978;83.8302 86.0232;24.5771;94.9303;1.16694E-12;39.6721;46.786;331.492;140.016;109.049;92.6554;55.6613;327.378;17.0471;63.9031;73.8251;38.3337;132.851;336.862;16.8623;63.2034;197.161;129.44 11 11 11 24825;78968;287877;362282;25087;85430;29680;58919;289054;25649;81639 TF_10003;SREBF1_32750;PYCR1_9631;PCK1_9439;KNG2_8975;HERPUD1_8795;CYP11A1_32785;CCND1_8224;ASPM_8092;APOA2_33095;ALOX15_8036 47.16539727272727 51.412 31.77526696959259 33.571031818181815 36.6131 24.26667364871536 83.96129090909089 86.0232 55.406924575876914 51.412;11.2357;54.7122;5.51457;73.9369;53.893;43.719;28.2655;10.3235;80.183;105.624 36.6131;4.94421;38.3856;1.34064;52.6626;37.9512;33.4848;22.3101;7.4611;50.2978;83.8302 86.0232;24.5771;94.9303;39.6721;140.016;92.6554;63.9031;38.3337;16.8623;197.161;129.44 11 29692;286918;58827;24516;81660;24367;499353;299691;24770;287562;29657 PLA2G2A_32641;MX2_9268;MEST_9219;JUN_8938;GATM_32792;FGG_8639;CYP2C24_32875;CRY1_8386;CCL2_8218;CCL12_8217;ARNTL_8086 44.77505454545465 37.423 30.776544330296673 28.192526363636468 27.1236 17.635314896038544 135.83226363636373 73.8251 131.20536086505962 1.16694E-12;31.6605;96.9172;57.7663;37.423;93.1824;10.5651;37.2548;64.0097;25.5289;38.2177 1.16694E-12;23.5989;56.7353;38.6865;28.03;51.338;7.63639;21.8798;41.1311;13.9582;27.1236 1.16694E-12;46.786;331.492;109.049;55.6613;327.378;17.0471;73.8251;132.851;336.862;63.2034 0 Exp 2,8(0.37);Hill,3(0.14);Linear,6(0.28);Poly 2,4(0.19);Power,1(0.05) 1.9900073892127579 45.634166955947876 1.5230457782745361 4.897102355957031 0.7326135073765587 1.9400842785835266 33.20396356242699 58.73648825575495 22.155438321731495 39.608119860086795 67.35550672186184 152.43804782359283 CONFLICT 0.5 0.5 0.0 GO:0001819 6 positive regulation of cytokine production 132 142 4 4 4 3 3 3 66 139 2339 0.45674 0.75087 1.0 2.11 360918;24770;25649 pf4;ccl2;apoa2 PF4_32963;CCL2_8218;APOA2_33095 83.33756666666666 80.183 64.0097 21.082902187870964 80.60070314116778 15.03616472396535 48.427 50.2978 41.1311 6.5636026486983585 48.92015502586844 5.105980293918389 146.629 132.851 109.875 45.24473905328663 170.9903651145602 44.04144046227198 105.82;64.0097;80.183 53.8521;41.1311;50.2978 109.875;132.851;197.161 1 2 1 25649 APOA2_33095 80.183 80.183 50.2978 50.2978 197.161 197.161 80.183 50.2978 197.161 2 360918;24770 PF4_32963;CCL2_8218 84.91485 84.91485 29.564346653443845 47.491600000000005 47.491600000000005 8.995105363474005 121.363 121.363 16.246485404542216 105.82;64.0097 53.8521;41.1311 109.875;132.851 0 Exp 2,1(0.34);Exp 3,1(0.34);Linear,1(0.34) 1.7818867829802822 5.371072292327881 1.559963583946228 1.9712703227996826 0.21007042158036376 1.8398383855819702 59.48001692987363 107.19511640345972 40.999584398083734 55.85441560191628 95.42975794721434 197.82824205278564 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0010038 5 response to metal ion 201 215 12 11 11 11 10 10 59 205 2273 0.97256 0.061006 0.076774 4.65 24825;290350;24516;24450;81660;24367;361921;29680;58919;81639 tf;loxl2;jun;hmgcs2;gatm;fgg;ect2;cyp11a1;ccnd1;alox15 TF_10003;LOXL2_9150;JUN_8938;HMGCS2_8812;GATM_32792;FGG_8639;ECT2_8523;CYP11A1_32785;CCND1_8224;ALOX15_8036 52.78483 47.5655 14.4142 28.857488479039343 51.776310151375185 28.246814374204625 37.222355 35.048950000000005 9.59235 20.168689196822584 37.58684533526872 21.10969577522136 100.98221999999998 74.96315 30.0753 87.68159273910473 88.12019739853335 65.3542326905437 51.412;65.4434;57.7663;30.5985;37.423;93.1824;14.4142;43.719;28.2655;105.624 36.6131;43.7615;38.6865;24.577;28.03;51.338;9.59235;33.4848;22.3101;83.8302 86.0232;129.393;109.049;40.5656;55.6613;327.378;30.0753;63.9031;38.3337;129.44 6 4 6 24825;24450;361921;29680;58919;81639 TF_10003;HMGCS2_8812;ECT2_8523;CYP11A1_32785;CCND1_8224;ALOX15_8036 45.6722 37.15875 32.05698307108764 35.067925 29.030900000000003 25.707897002239402 64.72348333333333 52.234350000000006 37.74413620203365 51.412;30.5985;14.4142;43.719;28.2655;105.624 36.6131;24.577;9.59235;33.4848;22.3101;83.8302 86.0232;40.5656;30.0753;63.9031;38.3337;129.44 4 290350;24516;81660;24367 LOXL2_9150;JUN_8938;GATM_32792;FGG_8639 63.453775 61.60485 23.077394213150814 40.454 41.224000000000004 9.778903219005024 155.37032499999998 119.221 118.81219983552126 65.4434;57.7663;37.423;93.1824 43.7615;38.6865;28.03;51.338 129.393;109.049;55.6613;327.378 0 Exp 2,5(0.5);Linear,3(0.3);Poly 2,2(0.2) 1.9724073849853774 20.21778655052185 1.5230457782745361 3.3687045574188232 0.5252973666180628 1.84433513879776 34.89877333541683 70.67088666458318 24.72167192472969 49.72303807527031 46.63660578233684 155.32783421766314 UP 0.6 0.4 0.0 GO:0044282 4 small molecule catabolic process 107 120 8 8 8 5 5 5 64 115 2363 0.89657 0.22314 0.25732 4.17 25044;362282;316033;171142;29740 sds;pck1;glb1;ehhadh;eci1 SDS_9798;PCK1_9439;GLB1_8712;EHHADH_8534;ECI1_8520 54.419293999999994 64.7394 5.51457 37.02988688384939 62.29495774452201 33.62367683451952 33.652988 43.4259 1.34064 20.449043316735388 38.03705213796917 16.478518904837507 86.67706000000001 107.244 39.6721 41.09741626255839 95.37922292804315 38.88088055442503 64.7394;5.51457;65.9159;32.6956;103.231 43.4259;1.34064;47.8573;25.6436;49.9975 126.828;39.6721;114.587;45.0542;107.244 4 1 4 362282;316033;171142;29740 PCK1_9439;GLB1_8712;EHHADH_8534;ECI1_8520 51.8392675 49.305749999999996 42.23631674167258 31.209760000000003 36.75045 22.754239378477724 76.639325 76.1491 39.752853210922694 5.51457;65.9159;32.6956;103.231 1.34064;47.8573;25.6436;49.9975 39.6721;114.587;45.0542;107.244 1 25044 SDS_9798 64.7394 64.7394 43.4259 43.4259 126.828 126.828 64.7394 43.4259 126.828 0 Exp 2,2(0.4);Exp 3,1(0.2);Hill,1(0.2);Linear,1(0.2) 1.9521210058365124 9.84208881855011 1.618504285812378 2.3449018001556396 0.2835503777522686 1.9179565906524658 21.9611670456053 86.8774209543947 15.728611235025234 51.57736476497477 50.653586346627115 122.70053365337287 UP 0.8 0.2 0.0 GO:0002682 4 regulation of immune system process 334 363 13 13 12 12 12 12 57 351 2127 0.8258 0.27175 0.48317 3.31 29142;29692;360918;314654;24516;84032;114851;24770;287562;25649;29339;81639 vnn1;pla2g2a;pf4;myo1f;jun;col3a1;cdkn1a;ccl2;ccl12;apoa2;apcs;alox15 VNN1_10157;PLA2G2A_32641;PF4_32963;MYO1F_32715;JUN_8938;COL3A1_8354;CDKN1A_8271;CCL2_8218;CCL12_8217;APOA2_33095;APCS_8057;ALOX15_8036 63.844758333333424 60.94355 1.16694E-12 35.11960532265422 66.24028375044813 33.069418812433064 41.35219166666676 40.276300000000006 1.16694E-12 22.950083698498734 43.287080923518154 22.998548551228204 145.76554166666676 110.291 1.16694E-12 115.0143194576021 186.93749996741295 125.40489184162226 20.8684;1.16694E-12;105.82;91.9576;57.7663;57.8774;54.5478;64.0097;25.5289;80.183;101.954;105.624 17.1194;1.16694E-12;53.8521;61.1322;38.6865;39.4215;38.2987;41.1311;13.9582;50.2978;58.4986;83.8302 26.5474;1.16694E-12;109.875;110.707;109.049;106.603;94.4701;132.851;336.862;197.161;395.621;129.44 4 8 4 29142;314654;25649;81639 VNN1_10157;MYO1F_32715;APOA2_33095;ALOX15_8036 74.65825000000001 86.0703 37.336380868486216 53.094899999999996 55.715 27.756784312068056 115.96385 120.0735 70.23180615995864 20.8684;91.9576;80.183;105.624 17.1194;61.1322;50.2978;83.8302 26.5474;110.707;197.161;129.44 8 29692;360918;24516;84032;114851;24770;287562;29339 PLA2G2A_32641;PF4_32963;JUN_8938;COL3A1_8354;CDKN1A_8271;CCL2_8218;CCL12_8217;APCS_8057 58.43801250000014 57.82185 35.22103234673569 35.48083750000015 39.054 19.475645374960955 160.66638750000016 109.462 133.8361822402983 1.16694E-12;105.82;57.7663;57.8774;54.5478;64.0097;25.5289;101.954 1.16694E-12;53.8521;38.6865;39.4215;38.2987;41.1311;13.9582;58.4986 1.16694E-12;109.875;109.049;106.603;94.4701;132.851;336.862;395.621 0 Exp 2,4(0.34);Exp 3,1(0.09);Hill,1(0.09);Linear,3(0.25);Poly 2,3(0.25) 1.7454398190174827 21.212518453598022 1.5230457782745361 2.642244338989258 0.3191735176221596 1.6445188522338867 43.97397101820296 83.71554564846389 28.36695940543913 54.33742392789439 80.69006433314874 210.8410190001848 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0009066 8 aspartate family amino acid metabolic process 14 14 3 3 2 3 2 2 67 12 2466 0.99441 0.053364 0.053364 14.29 25044;25612 sds;asns SDS_9798;ASNS_8091 75.20179999999999 75.20179999999999 64.7394 14.796067974972335 75.66151811745107 14.78177749883186 48.5625 48.5625 43.4259 7.264249384485615 48.78820233236152 7.257233359506374 175.65800000000002 175.65800000000002 126.828 69.05604825067809 177.8035914202416 68.98935189516394 0.0 64.7394 0.5 75.20179999999999 64.7394;85.6642 43.4259;53.6991 126.828;224.488 1 1 1 25612 ASNS_8091 85.6642 85.6642 53.6991 53.6991 224.488 224.488 85.6642 53.6991 224.488 1 25044 SDS_9798 64.7394 64.7394 43.4259 43.4259 126.828 126.828 64.7394 43.4259 126.828 0 Exp 2,1(0.5);Linear,1(0.5) 1.7495570957751696 3.5138999223709106 1.5959433317184448 1.9179565906524658 0.22769775902422584 1.7569499611854553 54.695496000000006 95.70810399999998 38.494763999999996 58.630236000000004 79.95120000000003 271.3648 CONFLICT 0.5 0.5 0.0 GO:0010039 6 response to iron ion 30 31 2 2 2 2 2 2 67 29 2449 0.95021 0.20433 0.20433 6.45 24825;58919 tf;ccnd1 TF_10003;CCND1_8224 39.83875 39.83875 28.2655 16.367047110734426 37.725819209311275 16.091963151602066 29.4616 29.4616 22.3101 10.113748291311188 28.155949076567907 9.94376467100274 62.17845 62.17845 38.3337 33.72156884139585 57.825108762985764 33.154804256294796 0.5 39.83875 51.412;28.2655 36.6131;22.3101 86.0232;38.3337 2 0 2 24825;58919 TF_10003;CCND1_8224 39.83875 39.83875 16.367047110734426 29.4616 29.4616 10.113748291311188 62.17845 62.17845 33.72156884139585 51.412;28.2655 36.6131;22.3101 86.0232;38.3337 0 0 Linear,2(1) 2.1321876850255603 4.272457838058472 2.0048909187316895 2.2675669193267822 0.1857399812757517 2.136228919029236 17.15518 62.52231999999999 15.444659999999995 43.47854000000001 15.44274 108.91416 UP 1.0 0.0 0.0 GO:0051129 6 negative regulation of cellular component organization 177 187 4 4 3 4 3 3 66 184 2294 0.24134 0.89331 0.4813 1.6 360243;306575;25649 top2a;ckap2;apoa2 TOP2A_10059;CKAP2_8324;APOA2_33095 35.3813 13.8391 12.1218 38.808910342729284 62.10728957758262 36.46637618877361 22.694826666666668 9.31624 8.47044 23.90861658566914 39.15802268506901 22.47275769700072 82.07883333333334 27.6952 21.3803 99.71408277682411 150.75745442910917 93.62653694108074 13.8391;12.1218;80.183 9.31624;8.47044;50.2978 27.6952;21.3803;197.161 3 0 3 360243;306575;25649 TOP2A_10059;CKAP2_8324;APOA2_33095 35.3813 13.8391 38.808910342729284 22.694826666666668 9.31624 23.90861658566914 82.07883333333334 27.6952 99.71408277682411 13.8391;12.1218;80.183 9.31624;8.47044;50.2978 27.6952;21.3803;197.161 0 0 Linear,1(0.34);Poly 2,2(0.67) 2.0126875245903033 6.048961400985718 1.8943853378295898 2.1833057403564453 0.1496358458662241 1.9712703227996826 -8.53511627332837 79.29771627332838 -4.360319927841086 49.74997326117442 -30.758273631730916 194.91594029839757 UP 1.0 0.0 0.0 GO:0044248 4 cellular catabolic process 306 344 16 16 15 13 12 12 57 332 2146 0.87037 0.21315 0.36948 3.49 25044;362282;287167;85430;24440;360504;171142;29740;25086;499353;29657;25649 sds;pck1;hba-a1;herpud1;hbb;hba-a2;ehhadh;eci1;cyp2e1;cyp2c24;arntl;apoa2 SDS_9798;PCK1_9439;LOC287167_9118;HERPUD1_8795;HBB_8782;HBA2_32600;EHHADH_8534;ECI1_8520;CYP2E1_8421;CYP2C24_32875;ARNTL_8086;APOA2_33095 61.385797499999995 59.3162 5.51457 35.41969566635956 59.01675507558774 31.546132191801913 40.9856525 40.68855 1.34064 25.70946889499988 38.14200248118632 20.312539878928884 106.97490833333335 99.9497 17.0471 72.54723416842371 111.05234624281306 73.68390346632117 64.7394;5.51457;105.203;53.893;91.4283;101.406;32.6956;103.231;49.5529;10.5651;38.2177;80.183 43.4259;1.34064;82.0435;37.9512;54.7263;84.6435;25.6436;49.9975;26.9979;7.63639;27.1236;50.2978 126.828;39.6721;130.247;92.6554;277.036;115.953;45.0542;107.244;71.5977;17.0471;63.2034;197.161 8 4 8 362282;287167;85430;360504;171142;29740;25086;25649 PCK1_9439;LOC287167_9118;HERPUD1_8795;HBA2_32600;EHHADH_8534;ECI1_8520;CYP2E1_8421;APOA2_33095 66.45988375 67.03800000000001 36.95717560240073 44.864455 43.97435 28.413512425387125 99.94805 99.9497 50.96388544152757 5.51457;105.203;53.893;101.406;32.6956;103.231;49.5529;80.183 1.34064;82.0435;37.9512;84.6435;25.6436;49.9975;26.9979;50.2978 39.6721;130.247;92.6554;115.953;45.0542;107.244;71.5977;197.161 4 25044;24440;499353;29657 SDS_9798;HBB_8782;CYP2C24_32875;ARNTL_8086 51.237624999999994 51.47855 34.74363741266163 33.2280475 35.27475 20.48062717987476 121.028625 95.01570000000001 113.32526636840157 64.7394;91.4283;10.5651;38.2177 43.4259;54.7263;7.63639;27.1236 126.828;277.036;17.0471;63.2034 0 Exp 2,1(0.09);Exp 3,1(0.09);Hill,1(0.09);Linear,4(0.34);Poly 2,4(0.34);Power,1(0.09) 2.0382673762393915 25.795305013656616 1.5270863771438599 4.897102355957031 0.9042644054235238 1.8665524125099182 41.345218088964444 81.42637691103556 26.439151088494523 55.532153911505475 65.92744646075312 148.02237020591355 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0051173 6 positive regulation of nitrogen compound metabolic process 649 698 31 31 27 27 25 25 44 673 1805 0.96145 0.065745 0.10129 3.58 360243;24825;78968;29692;360918;362282;316351;114519;366960;24516;85430;24367;361921;24309;299691;498709;306575;114851;58919;24770;287562;282840;29657;25649;81639 top2a;tf;srebf1;pla2g2a;pf4;pck1;npas2;nfil3;maff;jun;herpud1;fgg;ect2;dbp;cry1;cks2;ckap2;cdkn1a;ccnd1;ccl2;ccl12;atf5;arntl;apoa2;alox15 TOP2A_10059;TF_10003;SREBF1_32750;PLA2G2A_32641;PF4_32963;PCK1_9439;NPAS2_9350;NFIL3_9304;MAFF_9172;JUN_8938;HERPUD1_8795;FGG_8639;ECT2_8523;DBP_8439;CRY1_8386;CKS2_8325;CKAP2_8324;CDKN1A_8271;CCND1_8224;CCL2_8218;CCL12_8217;ATF5_8097;ARNTL_8086;APOA2_33095;ALOX15_8036 46.612690800000045 50.6952 1.16694E-12 31.84615311851174 51.81887507077187 29.24958429106266 31.115339200000044 35.795 1.16694E-12 21.844689219150915 35.425461585410154 21.78314506132941 95.55032000000007 86.0232 1.16694E-12 84.25609021627649 114.07682108292148 88.42857373556555 13.8391;51.412;11.2357;1.16694E-12;105.82;5.51457;58.2312;33.1149;58.0695;57.7663;53.893;93.1824;14.4142;50.6952;37.2548;14.4197;12.1218;54.5478;28.2655;64.0097;25.5289;97.9563;38.2177;80.183;105.624 9.31624;36.6131;4.94421;1.16694E-12;53.8521;1.34064;35.795;25.603;40.1293;38.6865;37.9512;51.338;9.59235;40.5862;21.8798;9.6236;8.47044;38.2987;22.3101;41.1311;13.9582;75.2121;27.1236;50.2978;83.8302 27.6952;86.0232;24.5771;1.16694E-12;109.875;39.6721;99.4319;46.6318;104.733;109.049;92.6554;327.378;30.0753;59.5346;73.8251;29.0958;21.3803;94.4701;38.3337;132.851;336.862;114.804;63.2034;197.161;129.44 12 13 12 360243;24825;78968;362282;366960;85430;361921;498709;306575;58919;25649;81639 TOP2A_10059;TF_10003;SREBF1_32750;PCK1_9439;MAFF_9172;HERPUD1_8795;ECT2_8523;CKS2_8325;CKAP2_8324;CCND1_8224;APOA2_33095;ALOX15_8036 37.41600583333334 21.3426 32.21478279922616 26.201598333333333 15.966849999999999 24.452941955224507 68.40350833333333 39.0029 54.81814726651713 13.8391;51.412;11.2357;5.51457;58.0695;53.893;14.4142;14.4197;12.1218;28.2655;80.183;105.624 9.31624;36.6131;4.94421;1.34064;40.1293;37.9512;9.59235;9.6236;8.47044;22.3101;50.2978;83.8302 27.6952;86.0232;24.5771;39.6721;104.733;92.6554;30.0753;29.0958;21.3803;38.3337;197.161;129.44 13 29692;360918;316351;114519;24516;24367;24309;299691;114851;24770;287562;282840;29657 PLA2G2A_32641;PF4_32963;NPAS2_9350;NFIL3_9304;JUN_8938;FGG_8639;DBP_8439;CRY1_8386;CDKN1A_8271;CCL2_8218;CCL12_8217;ATF5_8097;ARNTL_8086 55.10193846153855 54.5478 30.238939155844854 35.65110000000009 38.2987 18.969211516999316 120.60891538461547 99.4319 100.13169807778849 1.16694E-12;105.82;58.2312;33.1149;57.7663;93.1824;50.6952;37.2548;54.5478;64.0097;25.5289;97.9563;38.2177 1.16694E-12;53.8521;35.795;25.603;38.6865;51.338;40.5862;21.8798;38.2987;41.1311;13.9582;75.2121;27.1236 1.16694E-12;109.875;99.4319;46.6318;109.049;327.378;59.5346;73.8251;94.4701;132.851;336.862;114.804;63.2034 0 Exp 2,4(0.16);Exp 3,1(0.04);Hill,3(0.12);Linear,7(0.28);Poly 2,8(0.32);Power,2(0.08) 2.1599923543470534 58.42996120452881 1.5230457782745361 5.737884044647217 1.131449308412089 1.9088982343673706 34.12899877754345 59.096382822456654 22.55222102609289 39.67845737390721 62.52193263521967 128.57870736478043 CONFLICT 0.48 0.52 0.0 GO:0050727 6 regulation of inflammatory response 108 115 5 5 3 4 2 2 67 113 2365 0.38904 0.82806 0.76843 1.74 84386;81639 slpi;alox15 SLPI_9890;ALOX15_8036 81.07165 81.07165 56.5193 34.722266358130994 78.79059265347884 34.572088970855745 61.58085 61.58085 39.3315 31.465332523985843 59.513754863574356 31.329241711840538 114.774 114.774 100.108 20.740856105763783 113.41144256480216 20.65114976149218 56.5193;105.624 39.3315;83.8302 100.108;129.44 1 1 1 81639 ALOX15_8036 105.624 105.624 83.8302 83.8302 129.44 129.44 105.624 83.8302 129.44 1 84386 SLPI_9890 56.5193 56.5193 39.3315 39.3315 100.108 100.108 56.5193 39.3315 100.108 0 Linear,1(0.5);Poly 2,1(0.5) 1.6359855768309517 3.273790121078491 1.5823365449905396 1.6914535760879517 0.07715739263192349 1.6368950605392456 32.94904400000001 129.194256 17.972123999999994 105.189576 86.02864000000001 143.51936 CONFLICT 0.5 0.5 0.0 GO:0007275 3 multicellular organism development 107 118 3 3 3 3 3 3 66 115 2363 0.60178 0.62872 1.0 2.54 366960;360504;81660 maff;hba-a2;gatm MAFF_9172;HBA2_32600;GATM_32792 65.63283333333334 58.0695 37.423 32.65515396661504 49.042599987139916 22.99576294981218 50.934266666666666 40.1293 28.03 29.81329525670273 36.54683628472222 19.580221490662275 92.11576666666667 104.733 55.6613 32.06506206080588 75.08105905992797 30.89299809611436 58.0695;101.406;37.423 40.1293;84.6435;28.03 104.733;115.953;55.6613 2 1 2 366960;360504 MAFF_9172;HBA2_32600 79.73775 79.73775 30.64353302289079 62.3864 62.3864 31.476292679094215 110.343 110.343 7.9337380849131725 58.0695;101.406 40.1293;84.6435 104.733;115.953 1 81660 GATM_32792 37.423 37.423 28.03 28.03 55.6613 55.6613 37.423 28.03 55.6613 0 Exp 2,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 1.9194585709701593 5.7830634117126465 1.778118371963501 2.1833407878875732 0.22246705734180872 1.8216042518615723 28.68004794454776 102.58561872211891 17.19734714456792 84.6711861887654 55.83073313038553 128.4008002029478 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0044092 4 negative regulation of molecular function 276 297 9 9 9 8 8 8 61 289 2189 0.58606 0.5644 1.0 2.69 84386;100911740;24516;85430;116663;114851;25649;29339 slpi;mrln;jun;herpud1;dusp6;cdkn1a;apoa2;apcs SLPI_9890;LOC100911740_32571;JUN_8938;HERPUD1_8795;DUSP6_8506;CDKN1A_8271;APOA2_33095;APCS_8057 67.67677499999999 57.1428 45.5478 20.529446884397217 66.71059115716615 20.40245224032589 43.8678 39.009 33.3115 9.217606735559315 43.44849683360514 9.116294121158628 166.7672875 104.5785 71.7388 114.75390237980002 163.05157251282864 117.81908614939182 56.5193;91.003;57.7663;53.893;45.5478;54.5478;80.183;101.954 39.3315;54.5666;38.6865;37.9512;33.3115;38.2987;50.2978;58.4986 100.108;273.335;109.049;92.6554;71.7388;94.4701;197.161;395.621 2 6 2 85430;25649 HERPUD1_8795;APOA2_33095 67.03800000000001 67.03800000000001 18.58983727739426 44.1245 44.1245 8.73036458459786 144.9082 144.9082 73.89661843196888 53.893;80.183 37.9512;50.2978 92.6554;197.161 6 84386;100911740;24516;116663;114851;29339 SLPI_9890;LOC100911740_32571;JUN_8938;DUSP6_8506;CDKN1A_8271;APCS_8057 67.8897 57.1428 22.819014817997704 43.78223333333333 39.009 10.181895030232191 174.05364999999998 104.5785 130.72437468239426 56.5193;91.003;57.7663;45.5478;54.5478;101.954 39.3315;54.5666;38.6865;33.3115;38.2987;58.4986 100.108;273.335;109.049;71.7388;94.4701;395.621 0 Exp 2,1(0.13);Linear,7(0.88) 1.6533879002301972 13.276419281959534 1.5230457782745361 1.9712703227996826 0.15742836824371692 1.6034149527549744 53.45059411615304 81.90295588384697 37.48032441555571 50.2552755844443 87.24689021043183 246.28768478956817 DOWN 0.25 0.75 0.0 GO:0042745 5 circadian sleep/wake cycle 2 2 1 1 1 1 1 1 68 1 2477 0.99928 0.053458 0.053458 50.0 316351 npas2 NPAS2_9350 58.2312 58.2312 58.2312 58.23120000000001 35.795 35.795 35.795 35.795 99.4319 99.4319 99.4319 99.4319 0.0 58.2312 0.0 58.2312 58.2312 35.795 99.4319 0 1 0 1 316351 NPAS2_9350 58.2312 58.2312 35.795 35.795 99.4319 99.4319 58.2312 35.795 99.4319 0 Power,1(1) 4.820915699005127 4.820915699005127 4.820915699005127 4.820915699005127 0.0 4.820915699005127 58.2312 58.2312 35.795 35.795 99.4319 99.4319 DOWN 0.0 1.0 0.0 GO:0051493 7 regulation of cytoskeleton organization 126 131 6 6 6 6 6 6 63 125 2353 0.93867 0.14087 0.16573 4.58 291441;314654;361921;306575;282840;81639 ska1;myo1f;ect2;ckap2;atf5;alox15 SKA1_9829;MYO1F_32715;ECT2_8523;CKAP2_8324;ATF5_8097;ALOX15_8036 55.66575 53.1859 11.9206 47.1440767145036 72.32466512424699 44.23826400683832 41.0976 35.362275 8.34831 36.113398491147855 54.549103750753005 34.67930149942821 71.24248333333334 70.39115 21.0483 52.04312655302011 89.68760946159638 48.49203097475823 11.9206;91.9576;14.4142;12.1218;97.9563;105.624 8.34831;61.1322;9.59235;8.47044;75.2121;83.8302 21.0483;110.707;30.0753;21.3803;114.804;129.44 5 1 5 291441;314654;361921;306575;81639 SKA1_9829;MYO1F_32715;ECT2_8523;CKAP2_8324;ALOX15_8036 47.20764 14.4142 47.34614847892065 34.2747 9.59235 35.7922087213202 62.530179999999994 30.0753 53.069078157407255 11.9206;91.9576;14.4142;12.1218;105.624 8.34831;61.1322;9.59235;8.47044;83.8302 21.0483;110.707;30.0753;21.3803;129.44 1 282840 ATF5_8097 97.9563 97.9563 75.2121 75.2121 114.804 114.804 97.9563 75.2121 114.804 0 Poly 2,6(1) 1.888998340163257 11.453215718269348 1.5863633155822754 2.385996103286743 0.3091034539821108 1.8030484914779663 17.94263210058113 93.38886789941887 12.20086293417133 69.99433706582867 29.59930913983007 112.88565752683661 UP 0.8333333333333334 0.16666666666666666 0.0 GO:0048245 8 eosinophil chemotaxis 9 9 2 2 2 2 2 2 67 7 2471 0.99858 0.023028 0.023028 22.22 24770;287562 ccl2;ccl12 CCL2_8218;CCL12_8217 44.7693 44.7693 25.5289 27.210034625483285 34.23643823814133 22.77067479305678 27.54465 27.54465 13.9582 19.214141854503943 20.10695641335915 16.079324470495745 234.8565 234.8565 132.851 144.2575615366488 290.6978458373669 120.72171408095208 0.0 25.5289 0.0 25.5289 64.0097;25.5289 41.1311;13.9582 132.851;336.862 0 2 0 2 24770;287562 CCL2_8218;CCL12_8217 44.7693 44.7693 27.210034625483285 27.54465 27.54465 19.214141854503943 234.8565 234.8565 144.2575615366488 64.0097;25.5289 41.1311;13.9582 132.851;336.862 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.545648698637383 3.091428756713867 1.5314651727676392 1.559963583946228 0.020151419797422698 1.5457143783569336 7.058116000000005 82.48048399999999 0.9152079999999962 54.174092 34.92572000000004 434.78728 DOWN 0.0 1.0 0.0 GO:0072677 8 eosinophil migration 9 9 2 2 2 2 2 2 67 7 2471 0.99858 0.023028 0.023028 22.22 24770;287562 ccl2;ccl12 CCL2_8218;CCL12_8217 44.7693 44.7693 25.5289 27.210034625483285 34.23643823814133 22.77067479305678 27.54465 27.54465 13.9582 19.214141854503943 20.10695641335915 16.079324470495745 234.8565 234.8565 132.851 144.2575615366488 290.6978458373669 120.72171408095208 0.0 25.5289 0.0 25.5289 64.0097;25.5289 41.1311;13.9582 132.851;336.862 0 2 0 2 24770;287562 CCL2_8218;CCL12_8217 44.7693 44.7693 27.210034625483285 27.54465 27.54465 19.214141854503943 234.8565 234.8565 144.2575615366488 64.0097;25.5289 41.1311;13.9582 132.851;336.862 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.545648698637383 3.091428756713867 1.5314651727676392 1.559963583946228 0.020151419797422698 1.5457143783569336 7.058116000000005 82.48048399999999 0.9152079999999962 54.174092 34.92572000000004 434.78728 DOWN 0.0 1.0 0.0 GO:0032940 5 secretion by cell 76 81 3 3 3 3 3 3 66 78 2400 0.82535 0.3772 0.48146 3.7 314654;24367;287562 myo1f;fgg;ccl12 MYO1F_32715;FGG_8639;CCL12_8217 70.22296666666666 91.9576 25.5289 38.71104145025467 50.935988148196046 39.76087803721845 42.1428 51.338 13.9582 24.894986368343332 30.493640889693523 26.12113877104917 258.3156666666667 327.378 110.707 127.92077790700506 281.57829257726627 117.19185012855273 91.9576;93.1824;25.5289 61.1322;51.338;13.9582 110.707;327.378;336.862 1 2 1 314654 MYO1F_32715 91.9576 91.9576 61.1322 61.1322 110.707 110.707 91.9576 61.1322 110.707 2 24367;287562 FGG_8639;CCL12_8217 59.35565 59.35565 47.83824862100411 32.6481 32.6481 26.43151005939691 332.12 332.12 6.7062007127719685 93.1824;25.5289 51.338;13.9582 327.378;336.862 0 Exp 2,1(0.34);Poly 2,2(0.67) 1.6676216311197807 5.026726722717285 1.5314651727676392 1.9088982343673706 0.20391922253217115 1.5863633155822754 26.41729947091271 114.02863386242062 13.971470920779236 70.31412907922076 113.55967936993741 403.071653963396 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0045664 8 regulation of neuron differentiation 157 165 3 3 3 3 3 3 66 162 2316 0.3356 0.83615 0.62296 1.82 338475;361921;289054 nrep;ect2;aspm NREP_9364;ECT2_8523;ASPM_8092 20.532899999999998 14.4142 10.3235 14.287707787815371 21.457170900353077 14.359278059727632 15.028916666666666 9.59235 7.4611 11.312428830752193 15.70652997253825 11.428178623876878 33.5007 30.0753 16.8623 18.58932207155494 35.061571184778344 18.235044338833603 36.861;14.4142;10.3235 28.0333;9.59235;7.4611 53.5645;30.0753;16.8623 2 1 2 361921;289054 ECT2_8523;ASPM_8092 12.368849999999998 12.368849999999998 2.892561709799816 8.526724999999999 8.526724999999999 1.5070213274038373 23.4688 23.4688 9.343001899817851 14.4142;10.3235 9.59235;7.4611 30.0753;16.8623 1 338475 NREP_9364 36.861 36.861 28.0333 28.0333 53.5645 53.5645 36.861 28.0333 53.5645 0 Linear,1(0.34);Poly 2,2(0.67) 1.6547088213680852 4.972429513931274 1.5452834367752075 1.7797720432281494 0.11757028355406812 1.6473740339279175 4.364836602700084 36.700963397299915 2.2276983586450765 27.830134974688256 12.464901799952788 54.53649820004722 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0030856 6 regulation of epithelial cell differentiation 50 51 4 4 4 4 4 4 65 47 2431 0.98873 0.04743 0.04743 7.84 366960;170568;58919;29657 maff;dmbt1;ccnd1;arntl MAFF_9172;DMBT1_32993;CCND1_8224;ARNTL_8086 36.574025 33.2416 21.7434 15.850721734855899 35.65923017116206 14.568655574377658 25.554675 24.71685 12.6557 11.427919649226038 25.072071804461654 10.509342123865748 91.688775 83.9682 38.3337 53.42051103352067 86.7603664495974 52.980944209531614 1.5 33.2416 58.0695;21.7434;28.2655;38.2177 40.1293;12.6557;22.3101;27.1236 104.733;160.485;38.3337;63.2034 3 1 3 366960;170568;58919 MAFF_9172;DMBT1_32993;CCND1_8224 36.02613333333333 28.2655 19.36664549175551 25.0317 22.3101 13.937539386850169 101.1839 104.733 61.152940289327105 58.0695;21.7434;28.2655 40.1293;12.6557;22.3101 104.733;160.485;38.3337 1 29657 ARNTL_8086 38.2177 38.2177 27.1236 27.1236 63.2034 63.2034 38.2177 27.1236 63.2034 0 Linear,2(0.5);Poly 2,1(0.25);Power,1(0.25) 2.3851022989316664 10.586106777191162 1.5998332500457764 4.897102355957031 1.525862108467875 2.0445855855941772 21.040317699841214 52.10773230015879 14.355313743758474 36.75403625624152 39.33667418714978 144.04087581285023 UP 0.75 0.25 0.0 GO:0051246 6 regulation of protein metabolic process 635 675 25 25 22 21 20 20 49 655 1823 0.73391 0.36184 0.67826 2.96 24825;78968;84386;29692;24516;85430;24440;24367;361921;116663;299691;498709;114851;58919;24770;287562;29657;25649;29339;81639 tf;srebf1;slpi;pla2g2a;jun;herpud1;hbb;fgg;ect2;dusp6;cry1;cks2;cdkn1a;ccnd1;ccl2;ccl12;arntl;apoa2;apcs;alox15 TF_10003;SREBF1_32750;SLPI_9890;PLA2G2A_32641;JUN_8938;HERPUD1_8795;HBB_8782;FGG_8639;ECT2_8523;DUSP6_8506;CRY1_8386;CKS2_8325;CDKN1A_8271;CCND1_8224;CCL2_8218;CCL12_8217;ARNTL_8086;APOA2_33095;APCS_8057;ALOX15_8036 51.270205000000054 52.6525 1.16694E-12 31.21843435482967 53.68981391415411 28.852617255411506 33.67231800000006 37.28215 1.16694E-12 20.701148551436308 35.655512493089475 19.712377943488708 130.47519500000004 93.56275 1.16694E-12 115.15597901667506 142.50139590110842 116.7313648542027 51.412;11.2357;56.5193;1.16694E-12;57.7663;53.893;91.4283;93.1824;14.4142;45.5478;37.2548;14.4197;54.5478;28.2655;64.0097;25.5289;38.2177;80.183;101.954;105.624 36.6131;4.94421;39.3315;1.16694E-12;38.6865;37.9512;54.7263;51.338;9.59235;33.3115;21.8798;9.6236;38.2987;22.3101;41.1311;13.9582;27.1236;50.2978;58.4986;83.8302 86.0232;24.5771;100.108;1.16694E-12;109.049;92.6554;277.036;327.378;30.0753;71.7388;73.8251;29.0958;94.4701;38.3337;132.851;336.862;63.2034;197.161;395.621;129.44 8 12 8 24825;78968;85430;361921;498709;58919;25649;81639 TF_10003;SREBF1_32750;HERPUD1_8795;ECT2_8523;CKS2_8325;CCND1_8224;APOA2_33095;ALOX15_8036 44.9308875 39.83875 34.483932490713805 31.895319999999998 29.4616 26.475068910546774 78.4201875 62.17845 61.224384493142175 51.412;11.2357;53.893;14.4142;14.4197;28.2655;80.183;105.624 36.6131;4.94421;37.9512;9.59235;9.6236;22.3101;50.2978;83.8302 86.0232;24.5771;92.6554;30.0753;29.0958;38.3337;197.161;129.44 12 84386;29692;24516;24440;24367;116663;299691;114851;24770;287562;29657;29339 SLPI_9890;PLA2G2A_32641;JUN_8938;HBB_8782;FGG_8639;DUSP6_8506;CRY1_8386;CDKN1A_8271;CCL2_8218;CCL12_8217;ARNTL_8086;APCS_8057 55.49641666666676 55.533550000000005 29.630152142794344 34.85698333333343 38.492599999999996 17.039007654460995 165.17853333333343 104.5785 131.28333793821886 56.5193;1.16694E-12;57.7663;91.4283;93.1824;45.5478;37.2548;54.5478;64.0097;25.5289;38.2177;101.954 39.3315;1.16694E-12;38.6865;54.7263;51.338;33.3115;21.8798;38.2987;41.1311;13.9582;27.1236;58.4986 100.108;1.16694E-12;109.049;277.036;327.378;71.7388;73.8251;94.4701;132.851;336.862;63.2034;395.621 0 Exp 2,4(0.2);Hill,2(0.1);Linear,9(0.45);Poly 2,4(0.2);Power,1(0.05) 1.8678405775346656 39.09537494182587 1.5230457782745361 4.897102355957031 0.7640096610187194 1.7233816385269165 37.588122891771334 64.95228710822879 24.599639626826814 42.74499637317331 80.00586196902242 180.94452803097772 DOWN 0.4 0.6 0.0 GO:1901074 8 regulation of engulfment of apoptotic cell 1 1 1 1 1 1 1 1 68 0 2478 1.0 0.027091 0.027091 100.0 81639 alox15 ALOX15_8036 105.624 105.624 105.624 105.624 83.8302 83.8302 83.8302 83.8302 129.44 129.44 129.44 129.44 0.0 105.624 0.0 105.624 105.624 83.8302 129.44 1 0 1 81639 ALOX15_8036 105.624 105.624 83.8302 83.8302 129.44 129.44 105.624 83.8302 129.44 0 0 Poly 2,1(1) 1.6914535760879517 1.6914535760879517 1.6914535760879517 1.6914535760879517 0.0 1.6914535760879517 105.624 105.624 83.8302 83.8302 129.44 129.44 UP 1.0 0.0 0.0 GO:0043408 7 regulation of MAPK cascade 190 203 11 11 9 9 8 8 61 195 2283 0.90621 0.17982 0.25673 3.94 24825;29692;24516;24367;116663;24770;287562;81639 tf;pla2g2a;jun;fgg;dusp6;ccl2;ccl12;alox15 TF_10003;PLA2G2A_32641;JUN_8938;FGG_8639;DUSP6_8506;CCL2_8218;CCL12_8217;ALOX15_8036 55.38388750000014 54.589150000000004 1.16694E-12 34.0254038764497 53.72958890750927 32.51650113460706 37.358575000000144 37.6498 1.16694E-12 24.874561900965976 37.38687625748585 25.966935323063463 149.16775000000015 119.2445 1.16694E-12 120.4079099046117 163.5577800330237 122.13733983792079 51.412;1.16694E-12;57.7663;93.1824;45.5478;64.0097;25.5289;105.624 36.6131;1.16694E-12;38.6865;51.338;33.3115;41.1311;13.9582;83.8302 86.0232;1.16694E-12;109.049;327.378;71.7388;132.851;336.862;129.44 2 6 2 24825;81639 TF_10003;ALOX15_8036 78.518 78.518 38.333672821685106 60.221650000000004 60.221650000000004 33.38753159796333 107.7316 107.7316 30.700313697420064 51.412;105.624 36.6131;83.8302 86.0232;129.44 6 29692;24516;24367;116663;24770;287562 PLA2G2A_32641;JUN_8938;FGG_8639;DUSP6_8506;CCL2_8218;CCL12_8217 47.672516666666866 51.65705 32.27215681539808 29.737550000000194 35.999 19.09219218913812 162.9798000000002 120.95 138.53909102285866 1.16694E-12;57.7663;93.1824;45.5478;64.0097;25.5289 1.16694E-12;38.6865;51.338;33.3115;41.1311;13.9582 1.16694E-12;109.049;327.378;71.7388;132.851;336.862 0 Exp 2,3(0.38);Hill,1(0.13);Linear,2(0.25);Poly 2,2(0.25) 1.7109072544986643 13.77572512626648 1.5230457782745361 2.0048909187316895 0.21139156913195045 1.6295512318611145 31.805485562624508 78.96228943737579 20.12138302876692 54.59576697123337 65.72932538999132 232.60617461000894 DOWN 0.25 0.75 0.0 GO:1904031 8 positive regulation of cyclin-dependent protein kinase activity 18 18 3 3 3 3 3 3 66 15 2463 0.99887 0.011601 0.011601 16.67 498709;114851;58919 cks2;cdkn1a;ccnd1 CKS2_8325;CDKN1A_8271;CCND1_8224 32.411 28.2655 14.4197 20.382712775536042 39.34568347146025 19.301878180854782 23.4108 22.3101 9.6236 14.369203017912985 28.43725225283063 13.005332863082417 53.96653333333334 38.3337 29.0958 35.379922041227466 64.92544607797363 36.17722351448464 0.0 14.4197 0.5 21.3426 14.4197;54.5478;28.2655 9.6236;38.2987;22.3101 29.0958;94.4701;38.3337 2 1 2 498709;58919 CKS2_8325;CCND1_8224 21.3426 21.3426 9.790459070952696 15.966849999999999 15.966849999999999 8.970710179523131 33.71475 33.71475 6.5321817339231805 14.4197;28.2655 9.6236;22.3101 29.0958;38.3337 1 114851 CDKN1A_8271 54.5478 54.5478 38.2987 38.2987 94.4701 94.4701 54.5478 38.2987 94.4701 0 Linear,2(0.67);Poly 2,1(0.34) 1.7943054596728907 5.4626123905181885 1.530501127243042 2.2675669193267822 0.3926129969449902 1.6645443439483643 9.34578917276971 55.47621082723029 7.150516068352392 39.6710839316476 13.930382605088447 94.00268406157821 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0000302 5 response to reactive oxygen species 109 115 7 7 6 6 6 6 63 109 2369 0.96615 0.088414 0.12788 5.22 24516;24440;360504;361921;25086;29680 jun;hbb;hba-a2;ect2;cyp2e1;cyp11a1 JUN_8938;HBB_8782;HBA2_32600;ECT2_8523;CYP2E1_8421;CYP11A1_32785 59.71445 53.6596 14.4142 32.12155998956153 54.086851490056894 29.636634858194387 41.355225 36.08565 9.59235 25.83307605129033 36.06013062362683 21.910983250319198 111.26901666666667 90.32335 30.0753 87.08079465782147 106.63216347248043 83.89667216022994 4.5 96.41714999999999 57.7663;91.4283;101.406;14.4142;49.5529;43.719 38.6865;54.7263;84.6435;9.59235;26.9979;33.4848 109.049;277.036;115.953;30.0753;71.5977;63.9031 4 2 4 360504;361921;25086;29680 HBA2_32600;ECT2_8523;CYP2E1_8421;CYP11A1_32785 52.273025000000004 46.63595 36.184298097597974 38.6796375 30.24135 32.260379609756995 70.38227499999999 67.7504 35.33081835681849 101.406;14.4142;49.5529;43.719 84.6435;9.59235;26.9979;33.4848 115.953;30.0753;71.5977;63.9031 2 24516;24440 JUN_8938;HBB_8782 74.59729999999999 74.59729999999999 23.8026284683016 46.7064 46.7064 11.341851348875977 193.04250000000002 193.04250000000002 118.78474685118454 57.7663;91.4283 38.6865;54.7263 109.049;277.036 0 Exp 2,2(0.34);Linear,1(0.17);Poly 2,3(0.5) 1.788025635543427 10.792580962181091 1.5230457782745361 2.2035675048828125 0.2212136072071145 1.7667140364646912 34.011848972569005 85.417051027431 20.684459094690016 62.025990905309996 41.58986898613766 180.94816434719564 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0051239 4 regulation of multicellular organismal process 724 769 31 30 27 25 23 23 46 746 1732 0.76334 0.32411 0.59527 2.99 29142;24825;78968;360918;338475;316351;366960;290350;24516;81660;24367;361921;116663;170568;299691;84032;58919;24770;282840;289054;29657;25649;29339 vnn1;tf;srebf1;pf4;nrep;npas2;maff;loxl2;jun;gatm;fgg;ect2;dusp6;dmbt1;cry1;col3a1;ccnd1;ccl2;atf5;aspm;arntl;apoa2;apcs VNN1_10157;TF_10003;SREBF1_32750;PF4_32963;NREP_9364;NPAS2_9350;MAFF_9172;LOXL2_9150;JUN_8938;GATM_32792;FGG_8639;ECT2_8523;DUSP6_8506;DMBT1_32993;CRY1_8386;COL3A1_8354;CCND1_8224;CCL2_8218;ATF5_8097;ASPM_8092;ARNTL_8086;APOA2_33095;APCS_8057 51.9156608695652 51.412 10.3235 29.086740361698407 54.05287868838565 27.341177434975176 33.79120260869565 35.795 4.94421 17.568610924383968 35.87212970565802 17.43434924618187 109.90421739130437 99.4319 16.8623 91.99466451202308 116.31431131347888 94.43080173938223 20.8684;51.412;11.2357;105.82;36.861;58.2312;58.0695;65.4434;57.7663;37.423;93.1824;14.4142;45.5478;21.7434;37.2548;57.8774;28.2655;64.0097;97.9563;10.3235;38.2177;80.183;101.954 17.1194;36.6131;4.94421;53.8521;28.0333;35.795;40.1293;43.7615;38.6865;28.03;51.338;9.59235;33.3115;12.6557;21.8798;39.4215;22.3101;41.1311;75.2121;7.4611;27.1236;50.2978;58.4986 26.5474;86.0232;24.5771;109.875;53.5645;99.4319;104.733;129.393;109.049;55.6613;327.378;30.0753;71.7388;160.485;73.8251;106.603;38.3337;132.851;114.804;16.8623;63.2034;197.161;395.621 9 14 9 29142;24825;78968;366960;361921;170568;58919;289054;25649 VNN1_10157;TF_10003;SREBF1_32750;MAFF_9172;ECT2_8523;DMBT1_32993;CCND1_8224;ASPM_8092;APOA2_33095 32.946133333333336 21.7434 24.554362060130995 22.34700666666667 17.1194 16.237909723145556 76.08866666666667 38.3337 66.01008663026433 20.8684;51.412;11.2357;58.0695;14.4142;21.7434;28.2655;10.3235;80.183 17.1194;36.6131;4.94421;40.1293;9.59235;12.6557;22.3101;7.4611;50.2978 26.5474;86.0232;24.5771;104.733;30.0753;160.485;38.3337;16.8623;197.161 14 360918;338475;316351;290350;24516;81660;24367;116663;299691;84032;24770;282840;29657;29339 PF4_32963;NREP_9364;NPAS2_9350;LOXL2_9150;JUN_8938;GATM_32792;FGG_8639;DUSP6_8506;CRY1_8386;COL3A1_8354;CCL2_8218;ATF5_8097;ARNTL_8086;APCS_8057 64.11035714285713 58.0543 25.523710307769637 41.14818571428572 39.054 14.530066667741433 131.6427857142857 107.826 101.6859464232577 105.82;36.861;58.2312;65.4434;57.7663;37.423;93.1824;45.5478;37.2548;57.8774;64.0097;97.9563;38.2177;101.954 53.8521;28.0333;35.795;43.7615;38.6865;28.03;51.338;33.3115;21.8798;39.4215;41.1311;75.2121;27.1236;58.4986 109.875;53.5645;99.4319;129.393;109.049;55.6613;327.378;71.7388;73.8251;106.603;132.851;114.804;63.2034;395.621 0 Exp 2,7(0.31);Exp 3,1(0.05);Hill,1(0.05);Linear,8(0.35);Poly 2,4(0.18);Power,2(0.09) 2.031427826580424 49.63757288455963 1.5230457782745361 4.897102355957031 0.9241513110071407 1.8398383855819702 40.0282518077996 63.80306993133083 26.61111772781414 40.97128748957716 72.30707879978507 147.5013559828236 DOWN 0.391304347826087 0.6086956521739131 0.0 GO:0090316 7 positive regulation of intracellular protein transport 45 48 3 3 3 2 2 2 67 46 2432 0.86089 0.37569 0.37569 4.17 361921;24770 ect2;ccl2 ECT2_8523;CCL2_8218 39.211949999999995 39.211949999999995 14.4142 35.069314366337416 35.5403013667426 34.68277386185825 25.361725 25.361725 9.59235 22.301263995147238 23.026851708428243 22.055455316221884 81.46315 81.46315 30.0753 72.67339441119427 73.85447061503416 71.87237474355912 14.4142;64.0097 9.59235;41.1311 30.0753;132.851 1 1 1 361921 ECT2_8523 14.4142 14.4142 9.59235 9.59235 30.0753 30.0753 14.4142 9.59235 30.0753 1 24770 CCL2_8218 64.0097 64.0097 41.1311 41.1311 132.851 132.851 64.0097 41.1311 132.851 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.6662471530842853 3.3397356271743774 1.559963583946228 1.7797720432281494 0.15542805212041372 1.6698678135871887 -9.391640000000002 87.81554 -5.546250000000001 56.2697 -19.257036 182.183336 CONFLICT 0.5 0.5 0.0 GO:0044281 3 small molecule metabolic process 449 498 26 26 24 22 20 20 49 478 2000 0.98088 0.03657 0.062897 4.02 29142;78968;25044;83792;287877;362282;24450;316033;81660;171142;29740;24306;25086;499353;29680;299691;791259;25612;25649;81639 vnn1;srebf1;sds;scd2;pycr1;pck1;hmgcs2;glb1;gatm;ehhadh;eci1;cyp4a2;cyp2e1;cyp2c24;cyp11a1;cry1;car14;asns;apoa2;alox15 VNN1_10157;SREBF1_32750;SDS_9798;SCD_9786;PYCR1_9631;PCK1_9439;HMGCS2_8812;GLB1_8712;GATM_32792;EHHADH_8534;ECI1_8520;CYP4A2_8425;CYP2E1_8421;CYP2C24_32875;CYP11A1_32785;CRY1_8386;CAR14_8195;ASNS_8091;APOA2_33095;ALOX15_8036 54.061848499999996 52.13255 5.51457 31.424938264751866 58.5297510077417 29.60659544620433 35.637696999999996 35.935199999999995 1.34064 20.391843225403974 38.953417953224694 19.535375772700036 105.75669 84.3777 17.0471 84.60406766045374 117.5952071311009 87.51768654443902 20.8684;11.2357;64.7394;83.9984;54.7122;5.51457;30.5985;65.9159;37.423;32.6956;103.231;59.5671;49.5529;10.5651;43.719;37.2548;98.1742;85.6642;80.183;105.624 17.1194;4.94421;43.4259;54.1928;38.3856;1.34064;24.577;47.8573;28.03;25.6436;49.9975;43.4174;26.9979;7.63639;33.4848;21.8798;55.9966;53.6991;50.2978;83.8302 26.5474;24.5771;126.828;206.18;94.9303;39.6721;40.5656;114.587;55.6613;45.0542;107.244;99.5908;71.5977;17.0471;63.9031;73.8251;356.234;224.488;197.161;129.44 15 5 15 29142;78968;83792;287877;362282;24450;316033;171142;29740;24306;25086;29680;25612;25649;81639 VNN1_10157;SREBF1_32750;SCD_9786;PYCR1_9631;PCK1_9439;HMGCS2_8812;GLB1_8712;EHHADH_8534;ECI1_8520;CYP4A2_8425;CYP2E1_8421;CYP11A1_32785;ASNS_8091;APOA2_33095;ALOX15_8036 55.53869799999999 54.7122 31.869249551416956 37.052350000000004 38.3856 21.32123098707047 99.03588666666668 94.9303 65.86790365161455 20.8684;11.2357;83.9984;54.7122;5.51457;30.5985;65.9159;32.6956;103.231;59.5671;49.5529;43.719;85.6642;80.183;105.624 17.1194;4.94421;54.1928;38.3856;1.34064;24.577;47.8573;25.6436;49.9975;43.4174;26.9979;33.4848;53.6991;50.2978;83.8302 26.5474;24.5771;206.18;94.9303;39.6721;40.5656;114.587;45.0542;107.244;99.5908;71.5977;63.9031;224.488;197.161;129.44 5 25044;81660;499353;299691;791259 SDS_9798;GATM_32792;CYP2C24_32875;CRY1_8386;CAR14_8195 49.631299999999996 37.423 33.215418669647995 31.393737999999995 28.03 18.816980858913585 125.91909999999999 73.8251 134.6744546508914 64.7394;37.423;10.5651;37.2548;98.1742 43.4259;28.03;7.63639;21.8798;55.9966 126.828;55.6613;17.0471;73.8251;356.234 0 Exp 2,11(0.55);Exp 3,1(0.05);Hill,2(0.1);Linear,3(0.15);Poly 2,3(0.15) 2.0171907188211837 41.224114775657654 1.5133047103881836 3.3687045574188232 0.4671895150775699 1.916516363620758 40.28926206285097 67.834434937149 26.700577662849724 44.57481633715028 68.67732249349383 142.83605750650617 UP 0.75 0.25 0.0 GO:0046165 5 alcohol biosynthetic process 38 41 3 3 2 3 2 2 67 39 2439 0.90227 0.30568 0.30568 4.88 362282;24450 pck1;hmgcs2 PCK1_9439;HMGCS2_8812 18.056535 18.056535 5.51457 17.737017001808677 26.063831283970067 13.651673324683987 12.958820000000001 12.958820000000001 1.34064 16.430587726091847 20.376334682946045 12.646152176901866 40.11885 40.11885 39.6721 0.6317999089898727 40.404073217802285 0.4862782712115193 5.51457;30.5985 1.34064;24.577 39.6721;40.5656 2 0 2 362282;24450 PCK1_9439;HMGCS2_8812 18.056535 18.056535 17.737017001808677 12.958820000000001 12.958820000000001 16.430587726091847 40.11885 40.11885 0.6317999089898727 5.51457;30.5985 1.34064;24.577 39.6721;40.5656 0 0 Exp 2,1(0.5);Hill,1(0.5) 2.81056602499993 5.713606357574463 2.3449018001556396 3.3687045574188232 0.723937872258282 2.8568031787872314 -6.525716400000004 42.6387864 -9.812812799999998 35.7304528 39.24322 40.99448 UP 1.0 0.0 0.0 GO:0034614 6 cellular response to reactive oxygen species 66 70 3 3 2 2 2 2 67 68 2410 0.70563 0.57222 0.71457 2.86 24516;361921 jun;ect2 JUN_8938;ECT2_8523 36.09025 36.09025 14.4142 30.65456388867733 39.85495034429992 30.188679166870752 24.139425000000003 24.139425000000003 9.59235 20.572670757858592 26.6659636572303 20.26000954931394 69.56215 69.56215 30.0753 55.842838805392056 76.42023335883704 54.99414542595861 57.7663;14.4142 38.6865;9.59235 109.049;30.0753 1 1 1 361921 ECT2_8523 14.4142 14.4142 9.59235 9.59235 30.0753 30.0753 14.4142 9.59235 30.0753 1 24516 JUN_8938 57.7663 57.7663 38.6865 38.6865 109.049 109.049 57.7663 38.6865 109.049 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.6464125536236895 3.3028178215026855 1.5230457782745361 1.7797720432281494 0.18153288285739425 1.6514089107513428 -6.394808000000005 78.575308 -4.372841999999995 52.651692 -7.832076000000001 146.956376 CONFLICT 0.5 0.5 0.0 GO:0046685 4 response to arsenic-containing substance 19 20 2 2 2 2 2 2 67 18 2460 0.98441 0.1005 0.1005 10.0 24587;114851 nefh;cdkn1a NEFH_33218;CDKN1A_8271 66.933 66.933 54.5478 17.515317812703266 66.2861374737622 17.491412059187716 38.862399999999994 38.862399999999994 38.2987 0.7971921851100084 38.83295869860476 0.7961041386300829 179.30555 179.30555 94.4701 119.97544396002458 174.8747072601556 119.81169566713643 0.0 54.5478 1.0 79.3182 79.3182;54.5478 39.4261;38.2987 264.141;94.4701 0 2 0 2 24587;114851 NEFH_33218;CDKN1A_8271 66.933 66.933 17.515317812703266 38.862399999999994 38.862399999999994 0.7971921851100084 179.30555 179.30555 119.97544396002458 79.3182;54.5478 39.4261;38.2987 264.141;94.4701 0 Exp 2,1(0.5);Linear,1(0.5) 1.7150578458435886 3.4316486120224 1.6645443439483643 1.7671042680740356 0.07252081782724003 1.7158243060112 42.65800800000001 91.207992 37.75754799999999 39.967251999999995 13.028068000000019 345.583032 DOWN 0.0 1.0 0.0 GO:0050764 6 regulation of phagocytosis 46 51 3 3 3 3 3 3 66 48 2430 0.95257 0.15842 0.15842 5.88 24770;25649;81639 ccl2;apoa2;alox15 CCL2_8218;APOA2_33095;ALOX15_8036 83.27223333333333 80.183 64.0097 20.978441626186957 86.98882233767662 18.59919524644498 58.4197 50.2978 41.1311 22.478372492464874 61.141954934300955 21.438135011523944 153.15066666666667 132.851 129.44 38.15220583836975 162.48803947440757 40.8419774665945 1.5 92.90350000000001 64.0097;80.183;105.624 41.1311;50.2978;83.8302 132.851;197.161;129.44 2 1 2 25649;81639 APOA2_33095;ALOX15_8036 92.90350000000001 92.90350000000001 17.989503620166875 67.06400000000001 67.06400000000001 23.710987429459763 163.3005 163.3005 47.8859783287342 80.183;105.624 50.2978;83.8302 197.161;129.44 1 24770 CCL2_8218 64.0097 64.0097 41.1311 41.1311 132.851 132.851 64.0097 41.1311 132.851 0 Exp 2,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 1.7326343048012733 5.222687482833862 1.559963583946228 1.9712703227996826 0.21006358688106458 1.6914535760879517 59.53289185001988 107.01157481664679 32.98302695744026 83.85637304255974 109.97738149718354 196.32395183614977 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0032287 8 peripheral nervous system myelin maintenance 4 4 1 1 1 1 1 1 68 3 2475 0.99581 0.1041 0.1041 25.0 299923 ndrg1 NDRG1_32364 99.6641 99.6641 99.6641 99.6641 42.5546 42.5546 42.5546 42.5546 105.409 105.409 105.409 105.409 0.0 99.6641 0.0 99.6641 99.6641 42.5546 105.409 0 1 0 1 299923 NDRG1_32364 99.6641 99.6641 42.5546 42.5546 105.409 105.409 99.6641 42.5546 105.409 0 Exp 3,1(1) 1.5226441621780396 1.5226441621780396 1.5226441621780396 1.5226441621780396 0.0 1.5226441621780396 99.6641 99.6641 42.5546 42.5546 105.409 105.409 DOWN 0.0 1.0 0.0 GO:0009612 4 response to mechanical stimulus 121 126 6 6 5 4 4 4 65 122 2356 0.74622 0.44797 0.77458 3.17 24516;84032;24770;25612 jun;col3a1;ccl2;asns JUN_8938;COL3A1_8354;CCL2_8218;ASNS_8091 66.32939999999999 60.94355 57.7663 13.215880406289045 68.66109191395172 14.548428487285586 43.23455 40.276300000000006 38.6865 7.051132715386955 44.431033222660304 7.861952252694836 143.24775 120.95 106.603 55.43904410777063 153.4810327177146 60.631352682344826 57.7663;57.8774;64.0097;85.6642 38.6865;39.4215;41.1311;53.6991 109.049;106.603;132.851;224.488 1 3 1 25612 ASNS_8091 85.6642 85.6642 53.6991 53.6991 224.488 224.488 85.6642 53.6991 224.488 3 24516;84032;24770 JUN_8938;COL3A1_8354;CCL2_8218 59.88446666666666 57.8774 3.572988713015347 39.74636666666667 39.4215 1.2542611583451135 116.16766666666666 109.049 14.49985990736934 57.7663;57.8774;64.0097 38.6865;39.4215;41.1311 109.049;106.603;132.851 0 Exp 2,4(1) 1.5668405532083283 6.26842999458313 1.5230457782745361 1.5959433317184448 0.03328855674121254 1.5747204422950745 53.37783720183678 79.2809627981632 36.3244399389208 50.1446600610792 88.91748677438481 197.57801322561517 DOWN 0.25 0.75 0.0 GO:0043627 3 response to estrogen 45 49 4 4 4 4 4 4 65 45 2433 0.99046 0.041857 0.041857 8.16 170568;29680;58919;25649 dmbt1;cyp11a1;ccnd1;apoa2 DMBT1_32993;CYP11A1_32785;CCND1_8224;APOA2_33095 43.47772500000001 35.99225 21.7434 26.147836743584854 48.72240336827713 30.225136997014552 29.6871 27.89745 12.6557 16.162840042723516 32.1338087739289 18.18630383252839 114.97070000000001 112.19405 38.3337 75.95596631676364 132.57860451686417 79.47640479012874 1.5 35.99225 21.7434;43.719;28.2655;80.183 12.6557;33.4848;22.3101;50.2978 160.485;63.9031;38.3337;197.161 4 0 4 170568;29680;58919;25649 DMBT1_32993;CYP11A1_32785;CCND1_8224;APOA2_33095 43.47772500000001 35.99225 26.147836743584854 29.6871 27.89745 16.162840042723516 114.97070000000001 112.19405 75.95596631676364 21.7434;43.719;28.2655;80.183 12.6557;33.4848;22.3101;50.2978 160.485;63.9031;38.3337;197.161 0 0 Exp 2,1(0.25);Linear,2(0.5);Poly 2,1(0.25) 1.8815958027351123 7.591438055038452 1.5998332500457764 2.2675669193267822 0.2897953534780522 1.8620189428329468 17.852844991286837 69.10260500871317 13.847516758130956 45.526683241869044 40.533853009571615 189.4075469904284 UP 1.0 0.0 0.0 GO:0046907 4 intracellular transport 174 183 5 5 5 5 5 5 64 178 2300 0.62406 0.56061 1.0 2.73 314654;286918;85430;114851;29657 myo1f;mx2;herpud1;cdkn1a;arntl MYO1F_32715;MX2_9268;HERPUD1_8795;CDKN1A_8271;ARNTL_8086 54.055319999999995 53.893 31.6605 23.39449659443435 48.68616285840736 20.54709444096286 37.62092 37.9512 23.5989 14.664238216729826 34.25157002813518 12.93542393356344 81.56438 92.6554 46.786 25.91101086318324 75.61963944614801 26.046900804253777 91.9576;31.6605;53.893;54.5478;38.2177 61.1322;23.5989;37.9512;38.2987;27.1236 110.707;46.786;92.6554;94.4701;63.2034 2 3 2 314654;85430 MYO1F_32715;HERPUD1_8795 72.9253 72.9253 26.915736783153477 49.5417 49.5417 16.39144229468535 101.68119999999999 101.68119999999999 12.76440877126729 91.9576;53.893 61.1322;37.9512 110.707;92.6554 3 286918;114851;29657 MX2_9268;CDKN1A_8271;ARNTL_8086 41.47533333333333 38.2177 11.786274072977182 29.67373333333333 27.1236 7.674530280305983 68.15316666666666 63.2034 24.224336745168777 31.6605;54.5478;38.2177 23.5989;38.2987;27.1236 46.786;94.4701;63.2034 0 Exp 2,1(0.2);Linear,2(0.4);Poly 2,1(0.2);Power,1(0.2) 2.207817197975889 12.331626534461975 1.5270863771438599 4.897102355957031 1.4356366642833323 1.6645443439483643 33.549139603659334 74.56150039634068 24.767148471583578 50.474691528416415 58.85237759092122 104.2763824090788 DOWN 0.4 0.6 0.0 GO:0016043 4 cellular component organization 805 877 30 29 29 24 23 23 46 854 1624 0.4786 0.62229 0.89838 2.62 360243;24825;25044;360918;338475;24587;299923;314654;286918;290350;293502;303575;24516;24367;361921;84032;498709;24770;287562;289054;25649;29339;81639 top2a;tf;sds;pf4;nrep;nefh;ndrg1;myo1f;mx2;loxl2;kif22;kif18b;jun;fgg;ect2;col3a1;cks2;ccl2;ccl12;aspm;apoa2;apcs;alox15 TOP2A_10059;TF_10003;SDS_9798;PF4_32963;NREP_9364;NEFH_33218;NDRG1_32364;MYO1F_32715;MX2_9268;LOXL2_9150;KIF22_8963;KIF18B_32882;JUN_8938;FGG_8639;ECT2_8523;COL3A1_8354;CKS2_8325;CCL2_8218;CCL12_8217;ASPM_8092;APOA2_33095;APCS_8057;ALOX15_8036 55.778882608695646 57.8774 3.6768 34.90168645743814 60.82209095111872 33.46492043526299 34.59540086956522 39.4215 1.12034 21.23610026518927 37.275031151391836 20.690921031404603 126.46104782608698 109.049 11.7489 108.7029165512627 152.79861436450776 116.81922542334401 13.8391;51.412;64.7394;105.82;36.861;79.3182;99.6641;91.9576;31.6605;65.4434;13.2391;3.6768;57.7663;93.1824;14.4142;57.8774;14.4197;64.0097;25.5289;10.3235;80.183;101.954;105.624 9.31624;36.6131;43.4259;53.8521;28.0333;39.4261;42.5546;61.1322;23.5989;43.7615;9.02099;1.12034;38.6865;51.338;9.59235;39.4215;9.6236;41.1311;13.9582;7.4611;50.2978;58.4986;83.8302 27.6952;86.0232;126.828;109.875;53.5645;264.141;105.409;110.707;46.786;129.393;25.4349;11.7489;109.049;327.378;30.0753;106.603;29.0958;132.851;336.862;16.8623;197.161;395.621;129.44 10 13 10 360243;24825;314654;293502;303575;361921;498709;289054;25649;81639 TOP2A_10059;TF_10003;MYO1F_32715;KIF22_8963;KIF18B_32882;ECT2_8523;CKS2_8325;ASPM_8092;APOA2_33095;ALOX15_8036 39.9089 14.41695 38.959407211580846 27.800792 9.607975 28.511043368770405 66.42436000000001 29.585549999999998 62.13665012197265 13.8391;51.412;91.9576;13.2391;3.6768;14.4142;14.4197;10.3235;80.183;105.624 9.31624;36.6131;61.1322;9.02099;1.12034;9.59235;9.6236;7.4611;50.2978;83.8302 27.6952;86.0232;110.707;25.4349;11.7489;30.0753;29.0958;16.8623;197.161;129.44 13 25044;360918;338475;24587;299923;286918;290350;24516;24367;84032;24770;287562;29339 SDS_9798;PF4_32963;NREP_9364;NEFH_33218;NDRG1_32364;MX2_9268;LOXL2_9150;JUN_8938;FGG_8639;COL3A1_8354;CCL2_8218;CCL12_8217;APCS_8057 67.98656153846153 64.7394 26.898530150410913 39.82202307692308 41.1311 12.208845903835028 172.6431153846154 126.828 115.9885904195167 64.7394;105.82;36.861;79.3182;99.6641;31.6605;65.4434;57.7663;93.1824;57.8774;64.0097;25.5289;101.954 43.4259;53.8521;28.0333;39.4261;42.5546;23.5989;43.7615;38.6865;51.338;39.4215;41.1311;13.9582;58.4986 126.828;109.875;53.5645;264.141;105.409;46.786;129.393;109.049;327.378;106.603;132.851;336.862;395.621 0 Exp 2,6(0.27);Exp 3,2(0.09);Exp 4,1(0.05);Linear,6(0.27);Poly 2,8(0.35) 1.7377309906878744 40.315842628479004 1.5226441621780396 2.6565301418304443 0.25321255893458255 1.6914535760879517 41.51497339419381 70.04279182319752 25.916456182404893 43.27434555672556 82.03544292216293 170.886652730011 CONFLICT 0.43478260869565216 0.5652173913043478 0.0 GO:0060416 6 response to growth hormone 18 18 2 2 2 2 2 2 67 16 2462 0.9884 0.083748 0.083748 11.11 79438;24450 igfals;hmgcs2 IGFALS_8880;HMGCS2_8812 50.4824 50.4824 30.5985 28.120081052870386 51.10439889001009 28.106319452778806 35.31145 35.31145 24.577 15.18080477461589 35.64724006054491 15.173375487197253 94.6808 94.6808 40.5656 76.53044977053248 96.3736064581231 76.49299676879363 0.0 30.5985 0.5 50.4824 70.3663;30.5985 46.0459;24.577 148.796;40.5656 1 1 1 24450 HMGCS2_8812 30.5985 30.5985 24.577 24.577 40.5656 40.5656 30.5985 24.577 40.5656 1 79438 IGFALS_8880 70.3663 70.3663 46.0459 46.0459 148.796 148.796 70.3663 46.0459 148.796 0 Exp 2,1(0.5);Linear,1(0.5) 2.2684710634473255 4.896283149719238 1.527578592300415 3.3687045574188232 1.3018726549538533 2.448141574859619 11.509956000000003 89.454844 14.271927999999999 56.350972 -11.384991999999997 200.74659200000002 CONFLICT 0.5 0.5 0.0 GO:0008202 5 steroid metabolic process 95 104 7 7 6 6 5 5 64 99 2379 0.93999 0.14846 0.20258 4.81 78968;24450;25086;29680;25649 srebf1;hmgcs2;cyp2e1;cyp11a1;apoa2 SREBF1_32750;HMGCS2_8812;CYP2E1_8421;CYP11A1_32785;APOA2_33095 43.05782000000001 43.719 11.2357 25.440048100327953 52.45860173788119 27.669050425103947 28.060342000000002 26.9979 4.94421 16.36724851669699 34.279141353693575 16.45392499847846 79.5609 63.9031 24.5771 68.34144873285172 108.48259389656131 82.97294352151187 11.2357;30.5985;49.5529;43.719;80.183 4.94421;24.577;26.9979;33.4848;50.2978 24.5771;40.5656;71.5977;63.9031;197.161 5 0 5 78968;24450;25086;29680;25649 SREBF1_32750;HMGCS2_8812;CYP2E1_8421;CYP11A1_32785;APOA2_33095 43.05782000000001 43.719 25.440048100327953 28.060342000000002 26.9979 16.36724851669699 79.5609 63.9031 68.34144873285172 11.2357;30.5985;49.5529;43.719;80.183 4.94421;24.577;26.9979;33.4848;50.2978 24.5771;40.5656;71.5977;63.9031;197.161 0 0 Exp 2,2(0.4);Hill,1(0.2);Linear,1(0.2);Poly 2,1(0.2) 2.3605149726592622 12.153729438781738 1.752767562866211 3.3687045574188232 0.6678696075955798 2.2035675048828125 20.7586346539465 65.3570053460535 13.713816127116901 42.4068678728831 19.656978981390473 139.46482101860954 UP 1.0 0.0 0.0 GO:0051094 5 positive regulation of developmental process 376 396 14 13 13 10 10 10 59 386 2092 0.48416 0.64874 1.0 2.53 29142;24825;360918;290350;24516;361921;170568;58919;289054;29657 vnn1;tf;pf4;loxl2;jun;ect2;dmbt1;ccnd1;aspm;arntl VNN1_10157;TF_10003;PF4_32963;LOXL2_9150;JUN_8938;ECT2_8523;DMBT1_32993;CCND1_8224;ASPM_8092;ARNTL_8086 41.427440000000004 33.2416 10.3235 29.4026884131064 41.05238135515045 23.973764732817017 26.917544999999997 24.71685 7.4611 15.780056582782137 27.60360735339337 14.036419771171404 76.98473 74.61330000000001 16.8623 49.388995301361305 83.02870861410061 48.33762868961917 20.8684;51.412;105.82;65.4434;57.7663;14.4142;21.7434;28.2655;10.3235;38.2177 17.1194;36.6131;53.8521;43.7615;38.6865;9.59235;12.6557;22.3101;7.4611;27.1236 26.5474;86.0232;109.875;129.393;109.049;30.0753;160.485;38.3337;16.8623;63.2034 6 4 6 29142;24825;361921;170568;58919;289054 VNN1_10157;TF_10003;ECT2_8523;DMBT1_32993;CCND1_8224;ASPM_8092 24.504500000000004 21.3059 14.57339005694968 17.625291666666666 14.88755 10.726378756990488 59.72115 34.204499999999996 54.988779679376414 20.8684;51.412;14.4142;21.7434;28.2655;10.3235 17.1194;36.6131;9.59235;12.6557;22.3101;7.4611 26.5474;86.0232;30.0753;160.485;38.3337;16.8623 4 360918;290350;24516;29657 PF4_32963;LOXL2_9150;JUN_8938;ARNTL_8086 66.81184999999999 61.60485 28.419217739937896 40.855925 41.224000000000004 11.114946175420739 102.8801 109.462 28.072277799280915 105.82;65.4434;57.7663;38.2177 53.8521;43.7615;38.6865;27.1236 109.875;129.393;109.049;63.2034 0 Exp 2,2(0.2);Exp 3,1(0.1);Linear,3(0.3);Poly 2,3(0.3);Power,1(0.1) 2.0419209557294753 21.836923599243164 1.5230457782745361 4.897102355957031 1.0152937198138352 1.8098052144050598 23.20346491533902 59.651415084660975 17.13696460004672 36.698125399953284 46.37311356606746 107.59634643393257 UP 0.6 0.4 0.0 GO:0046677 4 response to antibiotic 202 218 13 13 12 12 12 12 57 206 2272 0.9953 0.01245 0.014358 5.5 78968;24777;24587;24516;24450;24440;360504;361921;25086;29680;58919;24770 srebf1;slc10a1;nefh;jun;hmgcs2;hbb;hba-a2;ect2;cyp2e1;cyp11a1;ccnd1;ccl2 SREBF1_32750;SLC10A1_9832;NEFH_33218;JUN_8938;HMGCS2_8812;HBB_8782;HBA2_32600;ECT2_8523;CYP2E1_8421;CYP11A1_32785;CCND1_8224;CCL2_8218 48.306826666666666 46.63595 7.96762 31.427870438331226 46.367124950931135 28.743252897450862 32.21625916666667 30.24135 4.94421 22.468011115509196 29.585745837805483 17.381573304609795 98.2974 67.7504 11.4863 89.19967780364762 104.30136983814756 96.98284214605539 9.5 85.37325 11.2357;7.96762;79.3182;57.7663;30.5985;91.4283;101.406;14.4142;49.5529;43.719;28.2655;64.0097 4.94421;6.07525;39.4261;38.6865;24.577;54.7263;84.6435;9.59235;26.9979;33.4848;22.3101;41.1311 24.5771;11.4863;264.141;109.049;40.5656;277.036;115.953;30.0753;71.5977;63.9031;38.3337;132.851 7 5 7 78968;24450;360504;361921;25086;29680;58919 SREBF1_32750;HMGCS2_8812;HBA2_32600;ECT2_8523;CYP2E1_8421;CYP11A1_32785;CCND1_8224 39.884542857142854 30.5985 30.506275834045308 29.50712285714286 24.577 26.262064892828914 55.00078571428571 40.5656 31.89286234966631 11.2357;30.5985;101.406;14.4142;49.5529;43.719;28.2655 4.94421;24.577;84.6435;9.59235;26.9979;33.4848;22.3101 24.5771;40.5656;115.953;30.0753;71.5977;63.9031;38.3337 5 24777;24587;24516;24440;24770 SLC10A1_9832;NEFH_33218;JUN_8938;HBB_8782;CCL2_8218 60.098023999999995 64.0097 31.973889843321857 36.00905 39.4261 17.968362442150934 158.91266000000002 132.851 111.72091716114755 7.96762;79.3182;57.7663;91.4283;64.0097 6.07525;39.4261;38.6865;54.7263;41.1311 11.4863;264.141;109.049;277.036;132.851 0 Exp 2,5(0.42);Hill,1(0.09);Linear,2(0.17);Poly 2,4(0.34) 2.0274112737517758 25.066275477409363 1.5230457782745361 3.3687045574188232 0.566170904563149 1.7789452075958252 30.524834998191995 66.08881833514134 19.50378514628582 44.92873318704751 47.82793116826745 148.76686883173258 CONFLICT 0.5833333333333334 0.4166666666666667 0.0 GO:0022414 2 reproductive process 343 368 12 11 11 9 8 8 61 360 2118 0.31566 0.80155 0.60374 2.17 360243;24587;29680;498709;58919;24770;289054;29657 top2a;nefh;cyp11a1;cks2;ccnd1;ccl2;aspm;arntl TOP2A_10059;NEFH_33218;CYP11A1_32785;CKS2_8325;CCND1_8224;CCL2_8218;ASPM_8092;ARNTL_8086 36.51405 33.2416 10.3235 25.069380583264753 43.119258168644976 26.07224403537978 23.734579999999998 24.71685 7.4611 13.780309628111723 26.74495150362263 12.306649173131278 79.5106875 50.768550000000005 16.8623 83.05758417855887 103.6757550917219 100.23908949807942 13.8391;79.3182;43.719;14.4197;28.2655;64.0097;10.3235;38.2177 9.31624;39.4261;33.4848;9.6236;22.3101;41.1311;7.4611;27.1236 27.6952;264.141;63.9031;29.0958;38.3337;132.851;16.8623;63.2034 5 3 5 360243;29680;498709;58919;289054 TOP2A_10059;CYP11A1_32785;CKS2_8325;CCND1_8224;ASPM_8092 22.11336 14.4197 13.88622598073357 16.439168000000002 9.6236 11.211770470096148 35.17802 29.0958 17.773154838604217 13.8391;43.719;14.4197;28.2655;10.3235 9.31624;33.4848;9.6236;22.3101;7.4611 27.6952;63.9031;29.0958;38.3337;16.8623 3 24587;24770;29657 NEFH_33218;CCL2_8218;ARNTL_8086 60.51519999999999 64.0097 20.771890206478602 35.8936 39.4261 7.642737156935325 153.39846666666668 132.851 102.03248778331998 79.3182;64.0097;38.2177 39.4261;41.1311;27.1236 264.141;132.851;63.2034 0 Exp 2,3(0.38);Linear,1(0.13);Poly 2,3(0.38);Power,1(0.13) 1.9843295421507556 17.214674592018127 1.530501127243042 4.897102355957031 1.1356377673409703 1.7599359154701233 19.141855569638587 53.88624443036141 14.185312622809693 33.28384737719031 21.954718118401146 137.06665688159887 UP 0.625 0.375 0.0 GO:1903531 6 negative regulation of secretion by cell 58 60 3 3 3 3 3 3 66 57 2421 0.92265 0.22059 0.22059 5.0 78968;299691;25649 srebf1;cry1;apoa2 SREBF1_32750;CRY1_8386;APOA2_33095 42.89116666666667 37.2548 11.2357 34.817510195637674 53.92621310977181 30.497421040696647 25.707270000000005 21.8798 4.94421 22.917769883273976 32.94544214340905 20.127525817575226 98.52106666666667 73.8251 24.5771 88.9028611013354 124.31563636738268 82.5392777991787 2.0 80.183 11.2357;37.2548;80.183 4.94421;21.8798;50.2978 24.5771;73.8251;197.161 2 1 2 78968;25649 SREBF1_32750;APOA2_33095 45.70935 45.70935 48.75310337450326 27.621005 27.621005 32.06983104015439 110.86905 110.86905 122.03524601362099 11.2357;80.183 4.94421;50.2978 24.5771;197.161 1 299691 CRY1_8386 37.2548 37.2548 21.8798 21.8798 73.8251 73.8251 37.2548 21.8798 73.8251 0 Exp 2,1(0.34);Hill,1(0.34);Linear,1(0.34) 2.1890340032432003 6.690937042236328 1.8622472286224365 2.857419490814209 0.5458196000011829 1.9712703227996826 3.491444854097317 82.290888479236 -0.22662799821490154 51.641167998214904 -2.081991278957773 199.1241246122911 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0042573 8 retinoic acid metabolic process 6 6 1 1 1 1 1 1 68 5 2473 0.98989 0.15206 0.15206 16.67 499353 cyp2c24 CYP2C24_32875 10.5651 10.5651 10.5651 10.5651 7.63639 7.63639 7.63639 7.63639 17.0471 17.0471 17.0471 17.0471 0.0 10.5651 0.0 10.5651 10.5651 7.63639 17.0471 0 1 0 1 499353 CYP2C24_32875 10.5651 10.5651 7.63639 7.63639 17.0471 17.0471 10.5651 7.63639 17.0471 0 Poly 2,1(1) 2.2906150817871094 2.2906150817871094 2.2906150817871094 2.2906150817871094 0.0 2.2906150817871094 10.5651 10.5651 7.63639 7.63639 17.0471 17.0471 DOWN 0.0 1.0 0.0 GO:0045347 8 negative regulation of MHC class II biosynthetic process 2 2 1 1 1 1 1 1 68 1 2477 0.99928 0.053458 0.053458 50.0 360918 pf4 PF4_32963 105.82 105.82 105.82 105.82 53.8521 53.8521 53.8521 53.8521 109.875 109.875 109.875 109.87500000000001 0.0 105.82 0.0 105.82 105.82 53.8521 109.875 0 1 0 1 360918 PF4_32963 105.82 105.82 53.8521 53.8521 109.875 109.875 105.82 53.8521 109.875 0 Exp 3,1(1) 1.8398383855819702 1.8398383855819702 1.8398383855819702 1.8398383855819702 0.0 1.8398383855819702 105.82 105.82 53.8521 53.8521 109.875 109.875 DOWN 0.0 1.0 0.0 GO:0044419 2 interspecies interaction between organisms 272 296 18 18 18 18 18 18 51 278 2200 0.99981 5.9446E-4 7.6996E-4 6.08 29142;24825;84386;29692;360918;362282;314654;286918;24516;24450;362376;360504;81714;170568;25086;24770;287562;29339 vnn1;tf;slpi;pla2g2a;pf4;pck1;myo1f;mx2;jun;hmgcs2;herc6;hba-a2;gas5;dmbt1;cyp2e1;ccl2;ccl12;apcs VNN1_10157;TF_10003;SLPI_9890;PLA2G2A_32641;PF4_32963;PCK1_9439;MYO1F_32715;MX2_9268;JUN_8938;HMGCS2_8812;HERC6_8794;HBA2_32600;GAS5_8688;DMBT1_32993;CYP2E1_8421;CCL2_8218;CCL12_8217;APCS_8057 50.54843166666673 50.48245 1.16694E-12 32.60443618965581 49.57877182190011 28.947470105793123 33.366007777777845 33.2259 1.16694E-12 21.7302557092754 32.33018578249984 17.956820051741207 113.30369444444452 99.23845 1.16694E-12 101.09122140212511 142.8210467321725 123.23942427335756 13.5 77.98365 20.8684;51.412;56.5193;1.16694E-12;105.82;5.51457;91.9576;31.6605;57.7663;30.5985;53.833;101.406;39.7267;21.7434;49.5529;64.0097;25.5289;101.954 17.1194;36.6131;39.3315;1.16694E-12;53.8521;1.34064;61.1322;23.5989;38.6865;24.577;36.3389;84.6435;30.1129;12.6557;26.9979;41.1311;13.9582;58.4986 26.5474;86.0232;100.108;1.16694E-12;109.875;39.6721;110.707;46.786;109.049;40.5656;98.3689;115.953;58.3946;160.485;71.5977;132.851;336.862;395.621 9 9 9 29142;24825;362282;314654;24450;360504;81714;170568;25086 VNN1_10157;TF_10003;PCK1_9439;MYO1F_32715;HMGCS2_8812;HBA2_32600;GAS5_8688;DMBT1_32993;CYP2E1_8421 45.864452222222226 39.7267 32.325075051951444 32.79914888888889 26.9979 25.62925512100403 78.88284444444444 71.5977 43.75271950890915 20.8684;51.412;5.51457;91.9576;30.5985;101.406;39.7267;21.7434;49.5529 17.1194;36.6131;1.34064;61.1322;24.577;84.6435;30.1129;12.6557;26.9979 26.5474;86.0232;39.6721;110.707;40.5656;115.953;58.3946;160.485;71.5977 9 84386;29692;360918;286918;24516;362376;24770;287562;29339 SLPI_9890;PLA2G2A_32641;PF4_32963;MX2_9268;JUN_8938;HERC6_8794;CCL2_8218;CCL12_8217;APCS_8057 55.23241111111125 56.5193 34.127773968588905 33.9328666666668 38.6865 18.597091700652822 147.7245444444446 109.049 130.90534919233718 56.5193;1.16694E-12;105.82;31.6605;57.7663;53.833;64.0097;25.5289;101.954 39.3315;1.16694E-12;53.8521;23.5989;38.6865;36.3389;41.1311;13.9582;58.4986 100.108;1.16694E-12;109.875;46.786;109.049;98.3689;132.851;336.862;395.621 0 Exp 2,7(0.39);Exp 3,1(0.06);Hill,2(0.12);Linear,3(0.17);Poly 2,5(0.28) 1.879859858946086 34.84961450099945 1.5059963464736938 3.3687045574188232 0.523071060249266 1.701305866241455 35.48595062137319 65.61091271196027 23.327141814066245 43.404873741489446 66.6019328388206 160.00545605006843 CONFLICT 0.5 0.5 0.0 GO:1902107 7 positive regulation of leukocyte differentiation 58 62 3 3 3 3 3 3 66 59 2419 0.91495 0.23506 0.23506 4.84 29142;360918;24516 vnn1;pf4;jun VNN1_10157;PF4_32963;JUN_8938 61.4849 57.7663 20.8684 42.5977062188799 58.833295988005375 34.6300410234699 36.55266666666667 38.6865 17.1194 18.459083017401845 36.65117881294592 15.217539935254122 81.8238 109.049 26.5474 47.87254815361303 89.49570052734983 43.214751303491305 20.8684;105.82;57.7663 17.1194;53.8521;38.6865 26.5474;109.875;109.049 1 2 1 29142 VNN1_10157 20.8684 20.8684 17.1194 17.1194 26.5474 26.5474 20.8684 17.1194 26.5474 2 360918;24516 PF4_32963;JUN_8938 81.79315 81.79315 33.97909713110399 46.2693 46.2693 10.723698600762708 109.462 109.462 0.5840702012598943 105.82;57.7663 53.8521;38.6865 109.875;109.049 0 Exp 2,2(0.67);Exp 3,1(0.34) 1.949045014685657 6.005128502845764 1.5230457782745361 2.642244338989258 0.5768908458876781 1.8398383855819702 13.28105758143142 109.68874241856858 15.664247830449078 57.441085502884256 27.65091201596765 135.99668798403235 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0009416 5 response to light stimulus 83 88 6 6 5 5 4 4 65 84 2394 0.91246 0.21373 0.29919 4.55 299691;114851;58919;25612 cry1;cdkn1a;ccnd1;asns CRY1_8386;CDKN1A_8271;CCND1_8224;ASNS_8091 51.433075 45.901300000000006 28.2655 25.29315746697447 49.04858029027372 22.569195496611464 34.046925 30.304399999999998 21.8798 15.16660327526129 32.52118763518511 13.977494130946026 107.779225 84.14760000000001 38.3337 81.18627658520353 98.94378714200161 70.97749433019247 37.2548;54.5478;28.2655;85.6642 21.8798;38.2987;22.3101;53.6991 73.8251;94.4701;38.3337;224.488 2 2 2 58919;25612 CCND1_8224;ASNS_8091 56.96485 56.96485 40.58701000129228 38.004599999999996 38.004599999999996 22.19537475466455 131.41085 131.41085 131.63096787703492 28.2655;85.6642 22.3101;53.6991 38.3337;224.488 2 299691;114851 CRY1_8386;CDKN1A_8271 45.901300000000006 45.901300000000006 12.227997567058939 30.08925 30.08925 11.609915529623787 84.14760000000001 84.14760000000001 14.598219497596176 37.2548;54.5478 21.8798;38.2987 73.8251;94.4701 0 Exp 2,2(0.5);Linear,2(0.5) 1.830111589510298 7.390301823616028 1.5959433317184448 2.2675669193267822 0.30189799829774894 1.7633957862854004 26.64578068236502 76.22036931763498 19.18365379024393 48.91019620975607 28.21667394650055 187.34177605349947 CONFLICT 0.5 0.5 0.0 GO:0017015 7 regulation of transforming growth factor beta receptor signaling pathway 30 31 1 1 1 1 1 1 68 30 2448 0.79567 0.57536 0.57536 3.23 338475 nrep NREP_9364 36.861 36.861 36.861 36.861 28.0333 28.0333 28.0333 28.033300000000004 53.5645 53.5645 53.5645 53.56450000000001 36.861 28.0333 53.5645 0 1 0 1 338475 NREP_9364 36.861 36.861 28.0333 28.0333 53.5645 53.5645 36.861 28.0333 53.5645 0 Linear,1(1) 1.6473740339279175 1.6473740339279175 1.6473740339279175 1.6473740339279175 0.0 1.6473740339279175 36.861 36.861 28.0333 28.0333 53.5645 53.5645 DOWN 0.0 1.0 0.0 GO:0051240 5 positive regulation of multicellular organismal process 484 516 19 18 17 15 14 14 55 502 1976 0.57378 0.54654 1.0 2.71 29142;24825;360918;316351;290350;24516;81660;24367;361921;58919;24770;289054;29657;25649 vnn1;tf;pf4;npas2;loxl2;jun;gatm;fgg;ect2;ccnd1;ccl2;aspm;arntl;apoa2 VNN1_10157;TF_10003;PF4_32963;NPAS2_9350;LOXL2_9150;JUN_8938;GATM_32792;FGG_8639;ECT2_8523;CCND1_8224;CCL2_8218;ASPM_8092;ARNTL_8086;APOA2_33095 51.82573571428572 54.589150000000004 10.3235 28.914179728654467 50.93483140793193 24.0264286460003 33.07940357142858 36.20405 7.4611 15.015887201054555 33.610787498215466 13.03635553943196 101.56039285714284 92.72755000000001 16.8623 82.15576458905987 98.82679635667989 68.75036409038486 20.8684;51.412;105.82;58.2312;65.4434;57.7663;37.423;93.1824;14.4142;28.2655;64.0097;10.3235;38.2177;80.183 17.1194;36.6131;53.8521;35.795;43.7615;38.6865;28.03;51.338;9.59235;22.3101;41.1311;7.4611;27.1236;50.2978 26.5474;86.0232;109.875;99.4319;129.393;109.049;55.6613;327.378;30.0753;38.3337;132.851;16.8623;63.2034;197.161 6 8 6 29142;24825;361921;58919;289054;25649 VNN1_10157;TF_10003;ECT2_8523;CCND1_8224;ASPM_8092;APOA2_33095 34.24443333333334 24.56695 26.777574086437824 23.898974999999997 19.71475 16.624784812133665 65.83381666666666 34.204499999999996 68.74736386461423 20.8684;51.412;14.4142;28.2655;10.3235;80.183 17.1194;36.6131;9.59235;22.3101;7.4611;50.2978 26.5474;86.0232;30.0753;38.3337;16.8623;197.161 8 360918;316351;290350;24516;81660;24367;24770;29657 PF4_32963;NPAS2_9350;LOXL2_9150;JUN_8938;GATM_32792;FGG_8639;CCL2_8218;ARNTL_8086 65.01171249999999 61.12045 24.01672590201839 39.964725 39.9088 9.741949918302506 128.355325 109.462 85.1144848676643 105.82;58.2312;65.4434;57.7663;37.423;93.1824;64.0097;38.2177 53.8521;35.795;43.7615;38.6865;28.03;51.338;41.1311;27.1236 109.875;99.4319;129.393;109.049;55.6613;327.378;132.851;63.2034 0 Exp 2,5(0.36);Exp 3,1(0.08);Linear,4(0.29);Poly 2,2(0.15);Power,2(0.15) 2.161725994506643 32.68147897720337 1.5230457782745361 4.897102355957031 1.1122803167201962 1.9400842785835266 36.6795621312936 66.97190929727783 25.213600834357962 40.94520630849918 58.524571575442494 144.5962141388432 CONFLICT 0.42857142857142855 0.5714285714285714 0.0 GO:0002376 2 immune system process 352 390 12 12 12 12 12 12 57 378 2100 0.75073 0.36321 0.61138 3.08 29142;84386;360918;114519;299923;314654;286918;24516;170568;24770;287562;29339 vnn1;slpi;pf4;nfil3;ndrg1;myo1f;mx2;jun;dmbt1;ccl2;ccl12;apcs VNN1_10157;SLPI_9890;PF4_32963;NFIL3_9304;NDRG1_32364;MYO1F_32715;MX2_9268;JUN_8938;DMBT1_32993;CCL2_8218;CCL12_8217;APCS_8057 59.21725833333333 57.1428 20.8684 33.28801568436683 58.23412997780294 32.93017017136402 35.67681666666667 39.009 12.6557 17.03479050429301 34.386760839078605 16.693018235235076 140.07768333333334 109.462 26.5474 112.95890062262657 163.01388642156792 127.78155178602718 20.8684;56.5193;105.82;33.1149;99.6641;91.9576;31.6605;57.7663;21.7434;64.0097;25.5289;101.954 17.1194;39.3315;53.8521;25.603;42.5546;61.1322;23.5989;38.6865;12.6557;41.1311;13.9582;58.4986 26.5474;100.108;109.875;46.6318;105.409;110.707;46.786;109.049;160.485;132.851;336.862;395.621 3 9 3 29142;314654;170568 VNN1_10157;MYO1F_32715;DMBT1_32993 44.85646666666667 21.7434 40.793124141371344 30.30243333333333 17.1194 26.79248101545159 99.24646666666668 110.707 67.70028095697485 20.8684;91.9576;21.7434 17.1194;61.1322;12.6557 26.5474;110.707;160.485 9 84386;360918;114519;299923;286918;24516;24770;287562;29339 SLPI_9890;PF4_32963;NFIL3_9304;NDRG1_32364;MX2_9268;JUN_8938;CCL2_8218;CCL12_8217;APCS_8057 64.0041888888889 57.7663 31.693699229162405 37.46827777777778 39.3315 14.321377814283258 153.68808888888887 109.049 124.76048875113115 56.5193;105.82;33.1149;99.6641;31.6605;57.7663;64.0097;25.5289;101.954 39.3315;53.8521;25.603;42.5546;23.5989;38.6865;41.1311;13.9582;58.4986 100.108;109.875;46.6318;105.409;46.786;109.049;132.851;336.862;395.621 0 Exp 2,4(0.34);Exp 3,2(0.17);Linear,3(0.25);Poly 2,3(0.25) 1.82030531212958 22.50430142879486 1.5226441621780396 2.835543394088745 0.513106007945925 1.5930982828140259 40.38279041349881 78.05172625316784 26.038476601089066 45.31515673224427 76.16516868513246 203.9901979815342 DOWN 0.25 0.75 0.0 GO:0055114 3 oxidation-reduction process 260 296 15 15 15 11 11 11 58 285 2193 0.90318 0.17049 0.25262 3.72 83792;287877;290350;171142;29740;24306;25086;499353;29680;25649;81639 scd2;pycr1;loxl2;ehhadh;eci1;cyp4a2;cyp2e1;cyp2c24;cyp11a1;apoa2;alox15 SCD_9786;PYCR1_9631;LOXL2_9150;EHHADH_8534;ECI1_8520;CYP4A2_8425;CYP2E1_8421;CYP2C24_32875;CYP11A1_32785;APOA2_33095;ALOX15_8036 62.662881818181816 59.5671 10.5651 29.115419256463337 66.34654748823426 27.931541334436357 41.60413545454545 43.4174 7.63639 19.477311518431577 44.74974299965138 19.834375873996727 105.59465454545456 99.5908 17.0471 58.47141083073612 118.33698232002791 59.156701276073264 83.9984;54.7122;65.4434;32.6956;103.231;59.5671;49.5529;10.5651;43.719;80.183;105.624 54.1928;38.3856;43.7615;25.6436;49.9975;43.4174;26.9979;7.63639;33.4848;50.2978;83.8302 206.18;94.9303;129.393;45.0542;107.244;99.5908;71.5977;17.0471;63.9031;197.161;129.44 9 2 9 83792;287877;171142;29740;24306;25086;29680;25649;81639 SCD_9786;PYCR1_9631;EHHADH_8534;ECI1_8520;CYP4A2_8425;CYP2E1_8421;CYP11A1_32785;APOA2_33095;ALOX15_8036 68.14257777777777 59.5671 26.184257252153337 45.13862222222222 43.4174 17.757960596643535 112.78901111111112 99.5908 56.254110167023434 83.9984;54.7122;32.6956;103.231;59.5671;49.5529;43.719;80.183;105.624 54.1928;38.3856;25.6436;49.9975;43.4174;26.9979;33.4848;50.2978;83.8302 206.18;94.9303;45.0542;107.244;99.5908;71.5977;63.9031;197.161;129.44 2 290350;499353 LOXL2_9150;CYP2C24_32875 38.00425 38.00425 38.80481806998971 25.698945 25.698945 25.544310252109963 73.22005 73.22005 79.44054772850576 65.4434;10.5651 43.7615;7.63639 129.393;17.0471 0 Exp 2,4(0.37);Exp 3,1(0.1);Linear,3(0.28);Poly 2,3(0.28) 1.8553969598398619 20.529820203781128 1.618504285812378 2.2906150817871094 0.21768508928717584 1.8151482343673706 45.45676857057713 79.86899506578649 30.093779900568215 53.1144910085227 71.04025889554379 140.1490501953653 UP 0.8181818181818182 0.18181818181818182 0.0 GO:0046395 6 carboxylic acid catabolic process 80 87 5 5 5 4 4 4 65 83 2395 0.91573 0.20799 0.29592 4.6 25044;362282;171142;29740 sds;pck1;ehhadh;eci1 SDS_9798;PCK1_9439;EHHADH_8534;ECI1_8520 51.5451425 48.7175 5.51457 42.10952051347247 61.72483098567885 37.31770817693546 30.10191 34.53475 1.34064 21.759675174024697 36.490828616689335 17.658316450426213 79.69957500000001 76.1491 39.6721 43.902484953692145 92.35490856068486 42.1514921433724 64.7394;5.51457;32.6956;103.231 43.4259;1.34064;25.6436;49.9975 126.828;39.6721;45.0542;107.244 3 1 3 362282;171142;29740 PCK1_9439;EHHADH_8534;ECI1_8520 47.147056666666664 32.6956 50.43568798804704 25.66058 25.6436 24.328434444188964 63.990100000000005 45.0542 37.55551422907162 5.51457;32.6956;103.231 1.34064;25.6436;49.9975 39.6721;45.0542;107.244 1 25044 SDS_9798 64.7394 64.7394 43.4259 43.4259 126.828 126.828 64.7394 43.4259 126.828 0 Exp 2,1(0.25);Exp 3,1(0.25);Hill,1(0.25);Linear,1(0.25) 1.9065462549644663 7.696510910987854 1.618504285812378 2.3449018001556396 0.3067958719744214 1.8665524125099182 10.277812396796989 92.812472603203 8.777428329455798 51.426391670544206 36.67513974538169 122.72401025461832 UP 0.75 0.25 0.0 GO:0007507 5 heart development 69 74 2 2 2 2 2 2 67 72 2406 0.67551 0.60294 1.0 2.7 84032;114851 col3a1;cdkn1a COL3A1_8354;CDKN1A_8271 56.2126 56.2126 54.5478 2.3543827386388494 54.97964150326798 1.5820065646741501 38.8601 38.8601 38.2987 0.7939394939157437 38.44432459150327 0.5334805895044218 100.53655 100.53655 94.4701 8.57925586545816 96.043709375 5.764754759892116 57.8774;54.5478 39.4215;38.2987 106.603;94.4701 0 2 0 2 84032;114851 COL3A1_8354;CDKN1A_8271 56.2126 56.2126 2.3543827386388494 38.8601 38.8601 0.7939394939157437 100.53655 100.53655 8.57925586545816 57.8774;54.5478 39.4215;38.2987 106.603;94.4701 0 Exp 2,1(0.5);Linear,1(0.5) 1.6265778341724544 3.254021644592285 1.589477300643921 1.6645443439483643 0.05308041536419612 1.6270108222961426 52.949592 59.475608 37.759755999999996 39.96044400000001 88.64630800000002 112.42679199999999 DOWN 0.0 1.0 0.0 GO:0018960 5 4-nitrophenol metabolic process 1 1 1 1 1 1 1 1 68 0 2478 1.0 0.027091 0.027091 100.0 25086 cyp2e1 CYP2E1_8421 49.5529 49.5529 49.5529 49.5529 26.9979 26.9979 26.9979 26.9979 71.5977 71.5977 71.5977 71.5977 0.0 49.5529 0.0 49.5529 49.5529 26.9979 71.5977 1 0 1 25086 CYP2E1_8421 49.5529 49.5529 26.9979 26.9979 71.5977 71.5977 49.5529 26.9979 71.5977 0 0 Poly 2,1(1) 2.2035675048828125 2.2035675048828125 2.2035675048828125 2.2035675048828125 0.0 2.2035675048828125 49.5529 49.5529 26.9979 26.9979 71.5977 71.5977 UP 1.0 0.0 0.0 GO:0016999 5 antibiotic metabolic process 46 51 6 6 6 6 6 6 63 45 2433 0.99965 0.0021853 0.0021853 11.76 362282;287167;24440;360504;24306;29680 pck1;hba-a1;hbb;hba-a2;cyp4a2;cyp11a1 PCK1_9439;LOC287167_9118;HBB_8782;HBA2_32600;CYP4A2_8425;CYP11A1_32785 67.80632833333334 75.4977 5.51457 39.02254209888965 66.62995176617713 30.575169866371425 49.94269 49.07185 1.34064 31.41048219618095 48.06397205027898 23.85825437388396 121.06700000000001 107.7719 39.6721 83.41561332587564 124.03057722696083 79.07597835707024 1.5 51.64305 4.5 103.3045 5.51457;105.203;91.4283;101.406;59.5671;43.719 1.34064;82.0435;54.7263;84.6435;43.4174;33.4848 39.6721;130.247;277.036;115.953;99.5908;63.9031 5 1 5 362282;287167;360504;24306;29680 PCK1_9439;LOC287167_9118;HBA2_32600;CYP4A2_8425;CYP11A1_32785 63.081934000000004 59.5671 41.66592404109478 48.985968 43.4174 35.020110113420834 89.87320000000001 99.5908 37.41399463923893 5.51457;105.203;101.406;59.5671;43.719 1.34064;82.0435;84.6435;43.4174;33.4848 39.6721;130.247;115.953;99.5908;63.9031 1 24440 HBB_8782 91.4283 91.4283 54.7263 54.7263 277.036 277.036 91.4283 54.7263 277.036 0 Exp 2,2(0.34);Hill,1(0.17);Linear,1(0.17);Poly 2,2(0.34) 1.858198081765279 11.221897959709167 1.6757243871688843 2.3449018001556396 0.24521237074262467 1.7667140364646912 36.581791574538705 99.03086509212798 24.809069707896505 75.0763102921035 54.32060818496461 187.81339181503537 UP 0.8333333333333334 0.16666666666666666 0.0 GO:0010212 5 response to ionizing radiation 75 76 6 6 6 6 6 6 63 70 2408 0.99611 0.015595 0.015595 7.89 360243;361921;29680;114851;58919;24770 top2a;ect2;cyp11a1;cdkn1a;ccnd1;ccl2 TOP2A_10059;ECT2_8523;CYP11A1_32785;CDKN1A_8271;CCND1_8224;CCL2_8218 36.46588333333333 35.99225 13.8391 20.99390195722717 39.311029250772506 19.598263285963565 25.688881666666664 27.89745 9.31624 14.119659064623933 27.881647502708773 13.067633930554722 64.55473333333333 51.1184 27.6952 41.939797183613884 68.08817813315142 38.97378622986587 2.5 35.99225 13.8391;14.4142;43.719;54.5478;28.2655;64.0097 9.31624;9.59235;33.4848;38.2987;22.3101;41.1311 27.6952;30.0753;63.9031;94.4701;38.3337;132.851 4 2 4 360243;361921;29680;58919 TOP2A_10059;ECT2_8523;CYP11A1_32785;CCND1_8224 25.05945 21.33985 14.114710582580154 18.675872499999997 15.951224999999999 11.58483268135648 40.001825 34.204499999999996 16.573497972239714 13.8391;14.4142;43.719;28.2655 9.31624;9.59235;33.4848;22.3101 27.6952;30.0753;63.9031;38.3337 2 114851;24770 CDKN1A_8271;CCL2_8218 59.27875 59.27875 6.690573652908962 39.7149 39.7149 2.0028092470327894 113.66055 113.66055 27.139394658042768 54.5478;64.0097 38.2987;41.1311 94.4701;132.851 0 Exp 2,2(0.34);Linear,2(0.34);Poly 2,2(0.34) 1.806846098643717 10.918999791145325 1.559963583946228 2.2675669193267822 0.24648450125917376 1.7662698030471802 19.66726314829361 53.26450351837305 14.390801383538667 36.98696194979467 30.99590634821479 98.11356031845187 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0042311 8 vasodilation 12 13 1 1 1 1 1 1 68 12 2466 0.95346 0.30085 0.30085 7.69 25087 kng2l1 KNG2_8975 73.9369 73.9369 73.9369 73.9369 52.6626 52.6626 52.6626 52.6626 140.016 140.016 140.016 140.016 0.0 73.9369 73.9369 52.6626 140.016 1 0 1 25087 KNG2_8975 73.9369 73.9369 52.6626 52.6626 140.016 140.016 73.9369 52.6626 140.016 0 0 Exp 2,1(1) 1.6083673238754272 1.6083673238754272 1.6083673238754272 1.6083673238754272 0.0 1.6083673238754272 73.9369 73.9369 52.6626 52.6626 140.016 140.016 UP 1.0 0.0 0.0 GO:0032102 6 negative regulation of response to external stimulus 106 114 7 7 4 7 4 4 65 110 2368 0.8062 0.3731 0.54881 3.51 84386;24367;114851;24770 slpi;fgg;cdkn1a;ccl2 SLPI_9890;FGG_8639;CDKN1A_8271;CCL2_8218 67.06479999999999 60.2645 54.5478 17.882445069769798 60.43841287864709 13.16600727037076 42.524825 40.231300000000005 38.2987 5.990881405032695 40.37649932168742 4.380714137494299 163.701775 116.4795 94.4701 110.42172188237767 125.22462103698196 79.72663773122419 56.5193;93.1824;54.5478;64.0097 39.3315;51.338;38.2987;41.1311 100.108;327.378;94.4701;132.851 0 4 0 4 84386;24367;114851;24770 SLPI_9890;FGG_8639;CDKN1A_8271;CCL2_8218 67.06479999999999 60.2645 17.882445069769798 42.524825 40.231300000000005 5.990881405032695 163.701775 116.4795 110.42172188237767 56.5193;93.1824;54.5478;64.0097 39.3315;51.338;38.2987;41.1311 100.108;327.378;94.4701;132.851 0 Exp 2,2(0.5);Linear,2(0.5) 1.6734890155756572 6.715742707252502 1.559963583946228 1.9088982343673706 0.15976612019711903 1.623440444469452 49.540003831625626 84.58959616837438 36.653761223067946 48.395888776932054 55.48848755526987 271.9150624447301 DOWN 0.0 1.0 0.0 GO:0033762 6 response to glucagon 17 18 4 4 4 4 4 4 65 14 2464 0.99992 0.0011336 0.0011336 22.22 78968;362282;24450;299691 srebf1;pck1;hmgcs2;cry1 SREBF1_32750;PCK1_9439;HMGCS2_8812;CRY1_8386 21.1508925 20.9171 5.51457 15.18111488965457 29.789520250888227 12.012079829726217 13.185412500000002 13.412005 1.34064 11.74133288846252 19.42744611150588 8.880694139960232 44.659975 40.11885 24.5771 20.78115482985726 54.599395435911454 21.818117860603532 0.0 5.51457 0.5 8.375135 11.2357;5.51457;30.5985;37.2548 4.94421;1.34064;24.577;21.8798 24.5771;39.6721;40.5656;73.8251 3 1 3 78968;362282;24450 SREBF1_32750;PCK1_9439;HMGCS2_8812 15.782923333333335 11.2357 13.145676707329802 10.287283333333335 4.94421 12.50573592382445 34.93826666666667 39.6721 8.98414807220658 11.2357;5.51457;30.5985 4.94421;1.34064;24.577 24.5771;39.6721;40.5656 1 299691 CRY1_8386 37.2548 37.2548 21.8798 21.8798 73.8251 73.8251 37.2548 21.8798 73.8251 0 Exp 2,2(0.5);Hill,2(0.5) 2.546242312970079 10.433273077011108 1.8622472286224365 3.3687045574188232 0.6496791412364459 2.6011606454849243 6.273399908138524 36.02838509186148 1.6789062693067311 24.691918730693274 24.29444326673988 65.02550673326013 UP 0.75 0.25 0.0 GO:0070848 5 response to growth factor 153 159 4 4 4 4 4 4 65 155 2323 0.56646 0.63492 1.0 2.52 79438;116663;29680;24770 igfals;dusp6;cyp11a1;ccl2 IGFALS_8880;DUSP6_8506;CYP11A1_32785;CCL2_8218 55.9107 54.77875 43.719 13.29894002868901 57.14681661407899 13.682817408642403 38.493325 37.307950000000005 33.3115 6.216533843643665 39.1245098901099 6.747517582464688 104.32222499999999 102.2949 63.9031 42.76756136858677 108.1093751931237 43.19269674135334 70.3663;45.5478;43.719;64.0097 46.0459;33.3115;33.4848;41.1311 148.796;71.7388;63.9031;132.851 1 3 1 29680 CYP11A1_32785 43.719 43.719 33.4848 33.4848 63.9031 63.9031 43.719 33.4848 63.9031 3 79438;116663;24770 IGFALS_8880;DUSP6_8506;CCL2_8218 59.9746 64.0097 12.891897050861047 40.16283333333333 41.1311 6.422179621696471 117.79526666666668 132.851 40.6750457604331 70.3663;45.5478;64.0097 46.0459;33.3115;41.1311 148.796;71.7388;132.851 0 Exp 2,2(0.5);Linear,2(0.5) 1.5996419597034075 6.407958626747131 1.527578592300415 1.752767562866211 0.1020072917394904 1.5638062357902527 42.87773877188478 68.94366122811522 32.40112183322925 44.585528166770764 62.410014858785 146.23443514121502 DOWN 0.25 0.75 0.0 GO:0060014 6 granulosa cell differentiation 1 1 1 1 1 1 1 1 68 0 2478 1.0 0.027091 0.027091 100.0 29680 cyp11a1 CYP11A1_32785 43.719 43.719 43.719 43.719 33.4848 33.4848 33.4848 33.4848 63.9031 63.9031 63.9031 63.9031 0.0 43.719 0.0 43.719 43.719 33.4848 63.9031 1 0 1 29680 CYP11A1_32785 43.719 43.719 33.4848 33.4848 63.9031 63.9031 43.719 33.4848 63.9031 0 0 Exp 2,1(1) 1.752767562866211 1.752767562866211 1.752767562866211 1.752767562866211 0.0 1.752767562866211 43.719 43.719 33.4848 33.4848 63.9031 63.9031 UP 1.0 0.0 0.0 GO:1901605 7 alpha-amino acid metabolic process 67 72 4 4 3 4 3 3 66 69 2409 0.87124 0.30941 0.44395 4.17 25044;287877;25612 sds;pycr1;asns SDS_9798;PYCR1_9631;ASNS_8091 68.37193333333333 64.7394 54.7122 15.792499796211253 66.87207254925663 15.98243465363818 45.1702 43.4259 38.3856 7.804342216356193 44.423711495225426 7.903020516890935 148.74876666666668 126.828 94.9303 67.50325485310563 143.033472416294 67.68164160715611 64.7394;54.7122;85.6642 43.4259;38.3856;53.6991 126.828;94.9303;224.488 2 1 2 287877;25612 PYCR1_9631;ASNS_8091 70.1882 70.1882 21.88636909128605 46.04235 46.04235 10.828279693700189 159.70915 159.70915 91.61112822493239 54.7122;85.6642 38.3856;53.6991 94.9303;224.488 1 25044 SDS_9798 64.7394 64.7394 43.4259 43.4259 126.828 126.828 64.7394 43.4259 126.828 0 Exp 2,1(0.34);Linear,2(0.67) 1.7192221651821613 5.174021005630493 1.5959433317184448 1.9179565906524658 0.1704359467144624 1.6601210832595825 50.501037476634735 86.24282919003193 36.33875540425599 54.00164459574401 72.3616428398584 225.13589049347496 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0071353 7 cellular response to interleukin-4 15 15 1 1 1 1 1 1 68 14 2464 0.93948 0.33842 0.33842 6.67 114519 nfil3 NFIL3_9304 33.1149 33.1149 33.1149 33.1149 25.603 25.603 25.603 25.602999999999998 46.6318 46.6318 46.6318 46.631800000000005 0.0 33.1149 33.1149 25.603 46.6318 0 1 0 1 114519 NFIL3_9304 33.1149 33.1149 25.603 25.603 46.6318 46.6318 33.1149 25.603 46.6318 0 Linear,1(1) 2.835543394088745 2.835543394088745 2.835543394088745 2.835543394088745 0.0 2.835543394088745 33.1149 33.1149 25.603 25.603 46.6318 46.6318 DOWN 0.0 1.0 0.0 GO:0043405 8 regulation of MAP kinase activity 90 99 2 2 2 2 2 2 67 97 2381 0.4925 0.75832 1.0 2.02 24825;116663 tf;dusp6 TF_10003;DUSP6_8506 48.4799 48.4799 45.5478 4.14661558623418 47.75264787186975 4.01704238268151 34.9623 34.9623 33.3115 2.33458374876563 34.552850181399876 2.2616328110674178 78.881 78.881 71.7388 10.100596105181042 77.10951193699673 9.784973263390949 51.412;45.5478 36.6131;33.3115 86.0232;71.7388 1 1 1 24825 TF_10003 51.412 51.412 36.6131 36.6131 86.0232 86.0232 51.412 36.6131 86.0232 1 116663 DUSP6_8506 45.5478 45.5478 33.3115 33.3115 71.7388 71.7388 45.5478 33.3115 71.7388 0 Linear,2(1) 1.7728409456513006 3.572539806365967 1.5676488876342773 2.0048909187316895 0.3091768052087594 1.7862699031829834 42.732984 54.226816 31.726732 38.197868 64.88228799999999 92.87971200000001 CONFLICT 0.5 0.5 0.0 GO:0044262 4 cellular carbohydrate metabolic process 38 40 2 2 2 2 2 2 67 38 2440 0.9077 0.29553 0.29553 5.0 362282;316033 pck1;glb1 PCK1_9439;GLB1_8712 35.715235 35.715235 5.51457 42.710190035686445 41.05113724663676 42.038275741437396 24.59897 24.59897 1.34064 32.89224572414903 28.708289291479822 32.37478677457418 77.12955 77.12955 39.6721 52.97283380191211 83.74759273542601 52.139468176316804 1.0 65.9159 5.51457;65.9159 1.34064;47.8573 39.6721;114.587 2 0 2 362282;316033 PCK1_9439;GLB1_8712 35.715235 35.715235 42.710190035686445 24.59897 24.59897 32.89224572414903 77.12955 77.12955 52.97283380191211 5.51457;65.9159 1.34064;47.8573 39.6721;114.587 0 0 Exp 2,1(0.5);Hill,1(0.5) 2.2430268606989316 4.4904797077178955 2.145577907562256 2.3449018001556396 0.14094327610528073 2.2452398538589478 -23.47806839999999 94.9085384 -20.9873568 70.1852968 3.7129480000000115 150.54615199999998 UP 1.0 0.0 0.0 GO:0002274 4 myeloid leukocyte activation 50 53 3 3 3 3 3 3 66 50 2428 0.9466 0.17174 0.17174 5.66 299923;314654;24516 ndrg1;myo1f;jun NDRG1_32364;MYO1F_32715;JUN_8938 83.12933333333335 91.9576 57.7663 22.300451351112404 85.39648545526212 22.565973623531967 47.457766666666664 42.5546 38.6865 11.999297672919576 45.2442186440678 10.172107941118385 108.38833333333334 109.049 105.409 2.710085115514181 107.60999566417028 2.7363996287880603 1.5 95.81085 99.6641;91.9576;57.7663 42.5546;61.1322;38.6865 105.409;110.707;109.049 1 2 1 314654 MYO1F_32715 91.9576 91.9576 61.1322 61.1322 110.707 110.707 91.9576 61.1322 110.707 2 299923;24516 NDRG1_32364;JUN_8938 78.71520000000001 78.71520000000001 29.626218496797676 40.62055 40.62055 2.7351597403076613 107.22900000000001 107.22900000000001 2.573868683518601 99.6641;57.7663 42.5546;38.6865 105.409;109.049 0 Exp 2,1(0.34);Exp 3,1(0.34);Poly 2,1(0.34) 1.5437300058906696 4.632053256034851 1.5226441621780396 1.5863633155822754 0.03667288357164927 1.5230457782745361 57.89399701572807 108.3646696509386 33.879283093235394 61.03625024009795 105.32158332623389 111.45508334043278 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0043269 6 regulation of ion transport 174 184 5 5 5 4 4 4 65 180 2298 0.43437 0.74709 0.81531 2.17 24825;24777;100911740;24770 tf;slc10a1;mrln;ccl2 TF_10003;SLC10A1_9832;LOC100911740_32571;CCL2_8218 53.598079999999996 57.71084999999999 7.96762 34.61429231213026 44.328707406997864 32.34710406552076 34.5965125 38.8721 6.07525 20.486046212742593 29.559384878761556 19.96433081424118 125.923875 109.4371 11.4863 110.25129972305315 92.92182762025118 91.13526337307111 51.412;7.96762;91.003;64.0097 36.6131;6.07525;54.5666;41.1311 86.0232;11.4863;273.335;132.851 1 3 1 24825 TF_10003 51.412 51.412 36.6131 36.6131 86.0232 86.0232 51.412 36.6131 86.0232 3 24777;100911740;24770 SLC10A1_9832;LOC100911740_32571;CCL2_8218 54.326773333333335 64.0097 42.356084386545135 33.92431666666667 41.1311 25.036094957397673 139.2241 132.851 131.0406338722078 7.96762;91.003;64.0097 6.07525;54.5666;41.1311 11.4863;273.335;132.851 0 Exp 2,1(0.25);Linear,2(0.5);Poly 2,1(0.25) 1.9319746580556911 7.833783864974976 1.559963583946228 2.4529356956481934 0.3767218659079339 1.910442292690277 19.67607353411234 87.52008646588766 14.520187211512262 54.67283778848774 17.877601271407926 233.97014872859205 DOWN 0.25 0.75 0.0 GO:0044866 7 modulation by host of viral exo-alpha-sialidase activity 1 1 1 1 1 1 1 1 68 0 2478 1.0 0.027091 0.027091 100.0 29339 apcs APCS_8057 101.954 101.954 101.954 101.954 58.4986 58.4986 58.4986 58.498599999999996 395.621 395.621 395.621 395.6209999999999 0.0 101.954 0.0 101.954 101.954 58.4986 395.621 0 1 0 1 29339 APCS_8057 101.954 101.954 58.4986 58.4986 395.621 395.621 101.954 58.4986 395.621 0 Linear,1(1) 1.6244933605194092 1.6244933605194092 1.6244933605194092 1.6244933605194092 0.0 1.6244933605194092 101.954 101.954 58.4986 58.4986 395.621 395.621 DOWN 0.0 1.0 0.0 GO:0044869 7 negative regulation by host of viral exo-alpha-sialidase activity 1 1 1 1 1 1 1 1 68 0 2478 1.0 0.027091 0.027091 100.0 29339 apcs APCS_8057 101.954 101.954 101.954 101.954 58.4986 58.4986 58.4986 58.498599999999996 395.621 395.621 395.621 395.6209999999999 0.0 101.954 0.0 101.954 101.954 58.4986 395.621 0 1 0 1 29339 APCS_8057 101.954 101.954 58.4986 58.4986 395.621 395.621 101.954 58.4986 395.621 0 Linear,1(1) 1.6244933605194092 1.6244933605194092 1.6244933605194092 1.6244933605194092 0.0 1.6244933605194092 101.954 101.954 58.4986 58.4986 395.621 395.621 DOWN 0.0 1.0 0.0 GO:0044871 7 negative regulation by host of viral glycoprotein metabolic process 1 1 1 1 1 1 1 1 68 0 2478 1.0 0.027091 0.027091 100.0 29339 apcs APCS_8057 101.954 101.954 101.954 101.954 58.4986 58.4986 58.4986 58.498599999999996 395.621 395.621 395.621 395.6209999999999 0.0 101.954 0.0 101.954 101.954 58.4986 395.621 0 1 0 1 29339 APCS_8057 101.954 101.954 58.4986 58.4986 395.621 395.621 101.954 58.4986 395.621 0 Linear,1(1) 1.6244933605194092 1.6244933605194092 1.6244933605194092 1.6244933605194092 0.0 1.6244933605194092 101.954 101.954 58.4986 58.4986 395.621 395.621 DOWN 0.0 1.0 0.0 GO:0052403 7 negative regulation by host of symbiont catalytic activity 1 1 1 1 1 1 1 1 68 0 2478 1.0 0.027091 0.027091 100.0 29339 apcs APCS_8057 101.954 101.954 101.954 101.954 58.4986 58.4986 58.4986 58.498599999999996 395.621 395.621 395.621 395.6209999999999 0.0 101.954 0.0 101.954 101.954 58.4986 395.621 0 1 0 1 29339 APCS_8057 101.954 101.954 58.4986 58.4986 395.621 395.621 101.954 58.4986 395.621 0 Linear,1(1) 1.6244933605194092 1.6244933605194092 1.6244933605194092 1.6244933605194092 0.0 1.6244933605194092 101.954 101.954 58.4986 58.4986 395.621 395.621 DOWN 0.0 1.0 0.0 GO:1903016 7 negative regulation of exo-alpha-sialidase activity 1 1 1 1 1 1 1 1 68 0 2478 1.0 0.027091 0.027091 100.0 29339 apcs APCS_8057 101.954 101.954 101.954 101.954 58.4986 58.4986 58.4986 58.498599999999996 395.621 395.621 395.621 395.6209999999999 0.0 101.954 0.0 101.954 101.954 58.4986 395.621 0 1 0 1 29339 APCS_8057 101.954 101.954 58.4986 58.4986 395.621 395.621 101.954 58.4986 395.621 0 Linear,1(1) 1.6244933605194092 1.6244933605194092 1.6244933605194092 1.6244933605194092 0.0 1.6244933605194092 101.954 101.954 58.4986 58.4986 395.621 395.621 DOWN 0.0 1.0 0.0 GO:0032091 6 negative regulation of protein binding 41 42 2 2 2 2 2 2 67 40 2438 0.89671 0.3158 0.3158 4.76 84386;114851 slpi;cdkn1a SLPI_9890;CDKN1A_8271 55.533550000000005 55.533550000000005 54.5478 1.3940610191090832 55.503082556099926 1.3933949887680512 38.8151 38.8151 38.2987 0.730299883608927 38.79913917014456 0.7299509735730719 97.28905 97.28905 94.4701 3.9865973216516952 97.20192222827073 3.9846926741951663 56.5193;54.5478 39.3315;38.2987 100.108;94.4701 0 2 0 2 84386;114851 SLPI_9890;CDKN1A_8271 55.533550000000005 55.533550000000005 1.3940610191090832 38.8151 38.8151 0.730299883608927 97.28905 97.28905 3.9865973216516952 56.5193;54.5478 39.3315;38.2987 100.108;94.4701 0 Linear,2(1) 1.622920006096049 3.246880888938904 1.5823365449905396 1.6645443439483643 0.05812969210949825 1.623440444469452 53.60148000000001 57.46562 37.802956 39.827244 91.763908 102.814192 DOWN 0.0 1.0 0.0 GO:0046888 6 negative regulation of hormone secretion 24 25 2 2 2 2 2 2 67 23 2455 0.97143 0.14577 0.14577 8.0 78968;299691 srebf1;cry1 SREBF1_32750;CRY1_8386 24.245250000000002 24.245250000000002 11.2357 18.39828205037089 32.44718768495974 14.281219094638756 13.412005 13.412005 4.94421 11.975270532395077 18.750569894174937 9.295512576798329 49.201100000000004 49.201100000000004 24.5771 34.823594759875085 64.72542740213522 27.030968710400078 0.5 24.245250000000002 11.2357;37.2548 4.94421;21.8798 24.5771;73.8251 1 1 1 78968 SREBF1_32750 11.2357 11.2357 4.94421 4.94421 24.5771 24.5771 11.2357 4.94421 24.5771 1 299691 CRY1_8386 37.2548 37.2548 21.8798 21.8798 73.8251 73.8251 37.2548 21.8798 73.8251 0 Exp 2,1(0.5);Hill,1(0.5) 2.3067773034648344 4.7196667194366455 1.8622472286224365 2.857419490814209 0.7036930550445591 2.3598333597183228 -1.253467999999998 49.743967999999995 -3.1848731999999966 30.008883199999993 0.9380600000000072 97.46414 CONFLICT 0.5 0.5 0.0 GO:0048856 3 anatomical structure development 699 756 31 29 27 27 24 24 45 732 1746 0.85813 0.20824 0.35138 3.17 360243;78968;338475;24587;366960;24516;24450;24440;360504;81660;361921;170568;24309;24306;29680;84032;114851;58919;24770;282840;289054;25612;25649;81639 top2a;srebf1;nrep;nefh;maff;jun;hmgcs2;hbb;hba-a2;gatm;ect2;dmbt1;dbp;cyp4a2;cyp11a1;col3a1;cdkn1a;ccnd1;ccl2;atf5;aspm;asns;apoa2;alox15 TOP2A_10059;SREBF1_32750;NREP_9364;NEFH_33218;MAFF_9172;JUN_8938;HMGCS2_8812;HBB_8782;HBA2_32600;GATM_32792;ECT2_8523;DMBT1_32993;DBP_8439;CYP4A2_8425;CYP11A1_32785;COL3A1_8354;CDKN1A_8271;CCND1_8224;CCL2_8218;ATF5_8097;ASPM_8092;ASNS_8091;APOA2_33095;ALOX15_8036 53.8556625 56.15705 10.3235 29.92980964963384 57.46008301927809 28.46927724891426 37.66294166666667 39.054 4.94421 22.19808250638127 39.84365122346763 20.780474501206744 105.89906666666667 102.1619 16.8623 73.94437266778239 114.38882721976331 73.30131499718962 13.8391;11.2357;36.861;79.3182;58.0695;57.7663;30.5985;91.4283;101.406;37.423;14.4142;21.7434;50.6952;59.5671;43.719;57.8774;54.5478;28.2655;64.0097;97.9563;10.3235;85.6642;80.183;105.624 9.31624;4.94421;28.0333;39.4261;40.1293;38.6865;24.577;54.7263;84.6435;28.03;9.59235;12.6557;40.5862;43.4174;33.4848;39.4215;38.2987;22.3101;41.1311;75.2121;7.4611;53.6991;50.2978;83.8302 27.6952;24.5771;53.5645;264.141;104.733;109.049;40.5656;277.036;115.953;55.6613;30.0753;160.485;59.5346;99.5908;63.9031;106.603;94.4701;38.3337;132.851;114.804;16.8623;224.488;197.161;129.44 14 10 14 360243;78968;366960;24450;360504;361921;170568;24306;29680;58919;289054;25612;25649;81639 TOP2A_10059;SREBF1_32750;MAFF_9172;HMGCS2_8812;HBA2_32600;ECT2_8523;DMBT1_32993;CYP4A2_8425;CYP11A1_32785;CCND1_8224;ASPM_8092;ASNS_8091;APOA2_33095;ALOX15_8036 47.475192857142865 37.15875 34.33377405819487 34.311342857142854 29.030900000000003 26.69089329928337 90.99022142857143 81.74695 67.91362031821326 13.8391;11.2357;58.0695;30.5985;101.406;14.4142;21.7434;59.5671;43.719;28.2655;10.3235;85.6642;80.183;105.624 9.31624;4.94421;40.1293;24.577;84.6435;9.59235;12.6557;43.4174;33.4848;22.3101;7.4611;53.6991;50.2978;83.8302 27.6952;24.5771;104.733;40.5656;115.953;30.0753;160.485;99.5908;63.9031;38.3337;16.8623;224.488;197.161;129.44 10 338475;24587;24516;24440;81660;24309;84032;114851;24770;282840 NREP_9364;NEFH_33218;JUN_8938;HBB_8782;GATM_32792;DBP_8439;COL3A1_8354;CDKN1A_8271;CCL2_8218;ATF5_8097 62.78832 57.82185 20.84566807121115 42.35518 39.4238 13.72215047819484 126.77145 107.826 80.50599896355898 36.861;79.3182;57.7663;91.4283;37.423;50.6952;57.8774;54.5478;64.0097;97.9563 28.0333;39.4261;38.6865;54.7263;28.03;40.5862;39.4215;38.2987;41.1311;75.2121 53.5645;264.141;109.049;277.036;55.6613;59.5346;106.603;94.4701;132.851;114.804 0 Exp 2,9(0.38);Hill,1(0.05);Linear,6(0.25);Poly 2,8(0.34) 1.9582038693275279 49.65323853492737 1.5230457782745361 5.737884044647217 0.896769192502698 1.7726113200187683 41.881244749095586 65.83008025090442 28.781859016556844 46.54402431677648 76.31515621024262 135.48297712309073 CONFLICT 0.5833333333333334 0.4166666666666667 0.0 GO:0007059 3 chromosome segregation 37 37 5 5 5 3 3 3 66 34 2444 0.98339 0.076811 0.076811 8.11 360243;291441;303575 top2a;ska1;kif18b TOP2A_10059;SKA1_9829;KIF18B_32882 9.812166666666668 11.9206 3.6768 5.399278068717458 9.057773619257086 5.4294134185867025 6.26163 8.34831 1.12034 4.478712903201096 5.682660061094818 4.5645169768124285 20.164133333333336 21.0483 11.7489 8.00983357775511 18.795523472629522 7.645257422892157 0.5 7.7987 13.8391;11.9206;3.6768 9.31624;8.34831;1.12034 27.6952;21.0483;11.7489 3 0 3 360243;291441;303575 TOP2A_10059;SKA1_9829;KIF18B_32882 9.812166666666668 11.9206 5.399278068717458 6.26163 8.34831 4.478712903201096 20.164133333333336 21.0483 8.00983357775511 13.8391;11.9206;3.6768 9.31624;8.34831;1.12034 27.6952;21.0483;11.7489 0 0 Exp 4,1(0.34);Poly 2,2(0.67) 1.8630175600370769 5.589689493179321 1.8263249397277832 1.8943853378295898 0.034392528470249595 1.8689792156219482 3.702308359715479 15.922024973617857 1.193489243439041 11.329770756560958 11.100153371662534 29.22811329500413 UP 1.0 0.0 0.0 GO:0036335 6 intestinal stem cell homeostasis 1 1 1 1 1 1 1 1 68 0 2478 1.0 0.027091 0.027091 100.0 29692 pla2g2a PLA2G2A_32641 1.16694E-12 1.16694E-12 1.16694E-12 1.16694E-12 1.16694E-12 1.16694E-12 1.16694E-12 1.16694E-12 1.16694E-12 1.16694E-12 1.16694E-12 1.16694E-12 0.0 1.16694E-12 0.0 1.16694E-12 1.16694E-12 1.16694E-12 1.16694E-12 0 1 0 1 29692 PLA2G2A_32641 1.16694E-12 1.16694E-12 1.16694E-12 1.16694E-12 1.16694E-12 1.16694E-12 1.16694E-12 1.16694E-12 1.16694E-12 0 Hill,1(1) 1.988358974456787 1.988358974456787 1.988358974456787 1.988358974456787 0.0 1.988358974456787 1.16694E-12 1.16694E-12 1.16694E-12 1.16694E-12 1.16694E-12 1.16694E-12 DOWN 0.0 1.0 0.0 GO:0048468 4 cell development 159 163 5 4 4 5 4 4 65 159 2319 0.5446 0.65475 1.0 2.45 24440;360504;282840;289054 hbb;hba-a2;atf5;aspm HBB_8782;HBA2_32600;ATF5_8097;ASPM_8092 75.278525 94.69229999999999 10.3235 43.5005629623629 80.74322871375567 39.12648649573178 55.51075 64.9692 7.4611 34.381412329484085 59.809799752645326 30.635889331748064 131.163825 115.3785 16.8623 107.76910987193487 125.39503004672255 92.03209458525212 91.4283;101.406;97.9563;10.3235 54.7263;84.6435;75.2121;7.4611 277.036;115.953;114.804;16.8623 2 2 2 360504;289054 HBA2_32600;ASPM_8092 55.86475 55.86475 64.40505339742371 46.0523 46.0523 54.57619842825259 66.40765 66.40765 70.06770592252182 101.406;10.3235 84.6435;7.4611 115.953;16.8623 2 24440;282840 HBB_8782;ATF5_8097 94.69229999999999 94.69229999999999 4.61599306758644 64.9692 64.9692 14.485648098031353 195.92000000000002 195.92000000000002 114.71534732545594 91.4283;97.9563 54.7263;75.2121 277.036;114.804 0 Linear,1(0.25);Poly 2,3(0.75) 1.841823778235014 7.464707612991333 1.5452834367752075 2.385996103286743 0.3620453282061476 1.7667140364646912 32.64797329688434 117.90907670311566 21.816965917105605 89.2045340828944 25.550097325503856 236.7775526744962 CONFLICT 0.5 0.5 0.0 GO:0030855 5 epithelial cell differentiation 87 96 3 3 3 3 3 3 66 93 2385 0.73891 0.48662 0.74377 3.12 362282;24516;29680 pck1;jun;cyp11a1 PCK1_9439;JUN_8938;CYP11A1_32785 35.666623333333334 43.719 5.51457 27.040551020358905 46.36300250231803 22.871755326177823 24.503980000000002 33.4848 1.34064 20.227942571828706 31.591594040333796 16.34728885929997 70.87473333333334 63.9031 39.6721 35.209960478582396 88.12913733194252 34.097627487146454 5.51457;57.7663;43.719 1.34064;38.6865;33.4848 39.6721;109.049;63.9031 2 1 2 362282;29680 PCK1_9439;CYP11A1_32785 24.616785 24.616785 27.01461152436677 17.41272 17.41272 22.729353511545373 51.7876 51.7876 17.133904414931287 5.51457;43.719 1.34064;33.4848 39.6721;63.9031 1 24516 JUN_8938 57.7663 57.7663 38.6865 38.6865 109.049 109.049 57.7663 38.6865 109.049 0 Exp 2,2(0.67);Hill,1(0.34) 1.8429801100499479 5.620715141296387 1.5230457782745361 2.3449018001556396 0.4240366285256794 1.752767562866211 5.06735928847888 66.26588737818778 1.6139081455647215 47.39405185443528 31.030912218820717 110.71855444784596 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0006694 6 steroid biosynthetic process 45 49 3 3 2 3 2 2 67 47 2431 0.85455 0.38548 0.38548 4.08 24450;29680 hmgcs2;cyp11a1 HMGCS2_8812;CYP11A1_32785 37.15875 37.15875 30.5985 9.277594522558136 33.63873405565132 7.828967724295575 29.030900000000003 29.030900000000003 24.577 6.298765785453517 26.64108268899286 5.315260751837235 52.234350000000006 52.234350000000006 40.5656 16.502104505941027 45.973279758680135 13.925424661083667 30.5985;43.719 24.577;33.4848 40.5656;63.9031 2 0 2 24450;29680 HMGCS2_8812;CYP11A1_32785 37.15875 37.15875 9.277594522558136 29.030900000000003 29.030900000000003 6.298765785453517 52.234350000000006 52.234350000000006 16.502104505941027 30.5985;43.719 24.577;33.4848 40.5656;63.9031 0 0 Exp 2,2(1) 2.429929232945538 5.121472120285034 1.752767562866211 3.3687045574188232 1.1426400068183613 2.560736060142517 24.30066 50.016839999999995 20.301256000000006 37.760543999999996 29.36360000000001 75.10510000000001 UP 1.0 0.0 0.0 GO:0051046 6 regulation of secretion 220 238 6 6 6 6 6 6 63 232 2246 0.53055 0.63667 1.0 2.52 78968;24777;24367;299691;29657;25649 srebf1;slc10a1;fgg;cry1;arntl;apoa2 SREBF1_32750;SLC10A1_9832;FGG_8639;CRY1_8386;ARNTL_8086;APOA2_33095 44.67353666666667 37.73625 7.96762 35.14586896975614 47.34237510478402 29.98769755215957 26.94311 24.5017 4.94421 20.42371694914518 29.506169966395795 18.010361633970884 116.27181666666667 68.51425 11.4863 122.56817432993634 110.48548466120852 95.96745184973483 11.2357;7.96762;93.1824;37.2548;38.2177;80.183 4.94421;6.07525;51.338;21.8798;27.1236;50.2978 24.5771;11.4863;327.378;73.8251;63.2034;197.161 2 4 2 78968;25649 SREBF1_32750;APOA2_33095 45.70935 45.70935 48.75310337450326 27.621005 27.621005 32.06983104015439 110.86905 110.86905 122.03524601362099 11.2357;80.183 4.94421;50.2978 24.5771;197.161 4 24777;24367;299691;29657 SLC10A1_9832;FGG_8639;CRY1_8386;ARNTL_8086 44.15563 37.73625 35.57188361504443 26.6041625 24.5017 18.759783067836675 118.97319999999999 68.51425 141.57991366515708 7.96762;93.1824;37.2548;38.2177 6.07525;51.338;21.8798;27.1236 11.4863;327.378;73.8251;63.2034 0 Exp 2,2(0.34);Hill,1(0.17);Linear,1(0.17);Poly 2,1(0.17);Power,1(0.17) 2.4937960957291314 15.949873328208923 1.8622472286224365 4.897102355957031 1.1628733254978179 2.212103009223938 16.55098445607771 72.79608887725561 10.600732842363566 43.28548715763644 18.19685130113909 214.34678203219426 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0010558 7 negative regulation of macromolecule biosynthetic process 265 277 11 11 10 11 10 10 59 267 2211 0.87748 0.21122 0.32536 3.61 78968;360918;114519;290350;24516;299691;114851;58919;282840;29657 srebf1;pf4;nfil3;loxl2;jun;cry1;cdkn1a;ccnd1;atf5;arntl SREBF1_32750;PF4_32963;NFIL3_9304;LOXL2_9150;JUN_8938;CRY1_8386;CDKN1A_8271;CCND1_8224;ATF5_8097;ARNTL_8086 52.962239999999994 46.38275 11.2357 30.200911904341197 53.64661164786956 25.878648035100237 35.167161 32.711149999999996 4.94421 19.607923079841676 37.10266415015803 19.028528832312634 80.41622 84.14760000000001 24.5771 36.26517862608399 85.100131921104 32.70739118687041 11.2357;105.82;33.1149;65.4434;57.7663;37.2548;54.5478;28.2655;97.9563;38.2177 4.94421;53.8521;25.603;43.7615;38.6865;21.8798;38.2987;22.3101;75.2121;27.1236 24.5771;109.875;46.6318;129.393;109.049;73.8251;94.4701;38.3337;114.804;63.2034 2 8 2 78968;58919 SREBF1_32750;CCND1_8224 19.7506 19.7506 12.04188706225067 13.627154999999998 13.627154999999998 12.279538580339652 31.4554 31.4554 9.727385146070851 11.2357;28.2655 4.94421;22.3101 24.5771;38.3337 8 360918;114519;290350;24516;299691;114851;282840;29657 PF4_32963;NFIL3_9304;LOXL2_9150;JUN_8938;CRY1_8386;CDKN1A_8271;ATF5_8097;ARNTL_8086 61.26515 56.15705 27.532619863769916 40.5521625 38.492599999999996 17.523531581434597 92.656425 101.75955 28.657937986770303 105.82;33.1149;65.4434;57.7663;37.2548;54.5478;97.9563;38.2177 53.8521;25.603;43.7615;38.6865;21.8798;38.2987;75.2121;27.1236 109.875;46.6318;129.393;109.049;73.8251;94.4701;114.804;63.2034 0 Exp 2,2(0.2);Exp 3,1(0.1);Hill,1(0.1);Linear,4(0.4);Poly 2,1(0.1);Power,1(0.1) 2.2441356376081725 23.87065017223358 1.5230457782745361 4.897102355957031 1.0001402795362049 2.0649070739746094 34.243520869764964 71.68095913023504 23.014044364934072 47.32027763506593 57.93882941458891 102.89361058541111 DOWN 0.2 0.8 0.0 GO:0006600 6 creatine metabolic process 2 2 1 1 1 1 1 1 68 1 2477 0.99928 0.053458 0.053458 50.0 81660 gatm GATM_32792 37.423 37.423 37.423 37.423 28.03 28.03 28.03 28.03 55.6613 55.6613 55.6613 55.6613 0.0 37.423 0.0 37.423 37.423 28.03 55.6613 0 1 0 1 81660 GATM_32792 37.423 37.423 28.03 28.03 55.6613 55.6613 37.423 28.03 55.6613 0 Exp 2,1(1) 2.1833407878875732 2.1833407878875732 2.1833407878875732 2.1833407878875732 0.0 2.1833407878875732 37.423 37.423 28.03 28.03 55.6613 55.6613 DOWN 0.0 1.0 0.0 GO:0006601 6 creatine biosynthetic process 2 2 1 1 1 1 1 1 68 1 2477 0.99928 0.053458 0.053458 50.0 81660 gatm GATM_32792 37.423 37.423 37.423 37.423 28.03 28.03 28.03 28.03 55.6613 55.6613 55.6613 55.6613 0.0 37.423 0.0 37.423 37.423 28.03 55.6613 0 1 0 1 81660 GATM_32792 37.423 37.423 28.03 28.03 55.6613 55.6613 37.423 28.03 55.6613 0 Exp 2,1(1) 2.1833407878875732 2.1833407878875732 2.1833407878875732 2.1833407878875732 0.0 2.1833407878875732 37.423 37.423 28.03 28.03 55.6613 55.6613 DOWN 0.0 1.0 0.0 GO:0031329 6 regulation of cellular catabolic process 171 183 4 4 2 4 2 2 67 181 2297 0.11556 0.96476 0.23366 1.09 78968;85430 srebf1;herpud1 SREBF1_32750;HERPUD1_8795 32.56435 32.56435 11.2357 30.163266097108924 38.21437613636363 29.085684295918085 21.447705 21.447705 4.94421 23.339466455556565 25.819532475782413 22.50566469744979 58.61625 58.61625 24.5771 48.138627581652145 67.63332736587184 46.41887651592574 11.2357;53.893 4.94421;37.9512 24.5771;92.6554 2 0 2 78968;85430 SREBF1_32750;HERPUD1_8795 32.56435 32.56435 30.163266097108924 21.447705 21.447705 23.339466455556565 58.61625 58.61625 48.138627581652145 11.2357;53.893 4.94421;37.9512 24.5771;92.6554 0 0 Hill,1(0.5);Linear,1(0.5) 2.0889055455447774 4.384505867958069 1.5270863771438599 2.857419490814209 0.940687565913318 2.1922529339790344 -9.239804 74.368504 -10.8991452 53.7945552 -8.100483999999987 125.33298399999998 UP 1.0 0.0 0.0 GO:0046486 5 glycerolipid metabolic process 62 68 6 6 4 6 4 4 65 64 2414 0.96486 0.11027 0.11027 5.88 29692;25086;25649;81639 pla2g2a;cyp2e1;apoa2;alox15 PLA2G2A_32641;CYP2E1_8421;APOA2_33095;ALOX15_8036 58.839975000000294 64.86795000000001 1.16694E-12 45.43369576062595 73.95539456939655 38.6226028427536 40.2814750000003 38.647850000000005 1.16694E-12 35.57090950288548 51.467152633602616 31.727572334917067 99.54967500000029 100.51885 1.16694E-12 83.89050998348436 133.5831591022685 77.49952066881107 2.5 92.90350000000001 1.16694E-12;49.5529;80.183;105.624 1.16694E-12;26.9979;50.2978;83.8302 1.16694E-12;71.5977;197.161;129.44 3 1 3 25086;25649;81639 CYP2E1_8421;APOA2_33095;ALOX15_8036 78.4533 80.183 28.07554025072356 53.70863333333333 50.2978 28.56926528357587 132.7329 129.44 62.84638390178065 49.5529;80.183;105.624 26.9979;50.2978;83.8302 71.5977;197.161;129.44 1 29692 PLA2G2A_32641 1.16694E-12 1.16694E-12 1.16694E-12 1.16694E-12 1.16694E-12 1.16694E-12 1.16694E-12 1.16694E-12 1.16694E-12 0 Hill,1(0.25);Linear,1(0.25);Poly 2,2(0.5) 1.9550454353440192 7.854650378227234 1.6914535760879517 2.2035675048828125 0.21001579658324748 1.9798146486282349 14.314953154586853 103.36499684541374 5.421983687172528 75.14096631282807 17.33697521618562 181.76237478381495 UP 0.75 0.25 0.0 GO:0071356 7 cellular response to tumor necrosis factor 67 70 4 4 4 4 4 4 65 66 2412 0.96086 0.11936 0.11936 5.71 362282;29680;24770;287562 pck1;cyp11a1;ccl2;ccl12 PCK1_9439;CYP11A1_32785;CCL2_8218;CCL12_8217 34.693042500000004 34.62395 5.51457 25.008659040138298 32.85005488917279 19.552697222341422 22.478685 23.7215 1.34064 18.151792967295734 20.064534435004795 14.368991776715255 143.32205 98.37705 39.6721 134.9296568441127 241.35321704886618 141.709298686124 2.5 53.86435 5.51457;43.719;64.0097;25.5289 1.34064;33.4848;41.1311;13.9582 39.6721;63.9031;132.851;336.862 2 2 2 362282;29680 PCK1_9439;CYP11A1_32785 24.616785 24.616785 27.01461152436677 17.41272 17.41272 22.729353511545373 51.7876 51.7876 17.133904414931287 5.51457;43.719 1.34064;33.4848 39.6721;63.9031 2 24770;287562 CCL2_8218;CCL12_8217 44.7693 44.7693 27.210034625483285 27.54465 27.54465 19.214141854503943 234.8565 234.8565 144.2575615366488 64.0097;25.5289 41.1311;13.9582 132.851;336.862 0 Exp 2,2(0.5);Hill,1(0.25);Poly 2,1(0.25) 1.77018087024744 7.189098119735718 1.5314651727676392 2.3449018001556396 0.37808623207357656 1.6563655734062195 10.18455664066446 59.20152835933555 4.689927892050186 40.26744210794982 11.0909862927696 275.5531137072304 CONFLICT 0.5 0.5 0.0 GO:0046456 6 icosanoid biosynthetic process 13 16 3 3 3 2 2 2 67 14 2464 0.99172 0.067982 0.067982 12.5 24306;81639 cyp4a2;alox15 CYP4A2_8425;ALOX15_8036 82.59555 82.59555 59.5671 32.56714631043068 82.4373261463779 32.56637758838539 63.6238 63.6238 43.4174 28.57616492673572 63.4849658849888 28.575490408687987 114.5154 114.5154 99.5908 21.106571732993476 114.41285607169532 21.106073528857305 0.0 59.5671 0.5 82.59555 59.5671;105.624 43.4174;83.8302 99.5908;129.44 2 0 2 24306;81639 CYP4A2_8425;ALOX15_8036 82.59555 82.59555 32.56714631043068 63.6238 63.6238 28.57616492673572 114.5154 114.5154 21.106571732993476 59.5671;105.624 43.4174;83.8302 99.5908;129.44 0 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.7997950938132505 3.606529712677002 1.6914535760879517 1.9150761365890503 0.15812502895662583 1.803264856338501 37.45978800000002 127.73131199999999 24.019256 103.228344 85.26318400000001 143.76761599999998 UP 1.0 0.0 0.0 GO:0051301 3 cell division 78 79 9 9 9 7 7 7 62 72 2406 0.99892 0.0048409 0.0048409 8.86 360243;291441;303575;498709;297594;58919;289054 top2a;ska1;kif18b;cks2;cdca3;ccnd1;aspm TOP2A_10059;SKA1_9829;KIF18B_32882;CKS2_8325;CDCA3_8260;CCND1_8224;ASPM_8092 12.152071428571428 11.9206 2.6193 8.502274151212777 14.316473249180182 10.243301743079039 8.451149 8.34831 0.978353 7.127034915733446 10.34794045065361 8.675947973488672 21.822024285714285 21.0483 7.96997 10.634708866699738 23.760517540990975 11.917455598704796 2.5 11.12205 13.8391;11.9206;3.6768;14.4197;2.6193;28.2655;10.3235 9.31624;8.34831;1.12034;9.6236;0.978353;22.3101;7.4611 27.6952;21.0483;11.7489;29.0958;7.96997;38.3337;16.8623 7 0 7 360243;291441;303575;498709;297594;58919;289054 TOP2A_10059;SKA1_9829;KIF18B_32882;CKS2_8325;CDCA3_8260;CCND1_8224;ASPM_8092 12.152071428571428 11.9206 8.502274151212777 8.451149 8.34831 7.127034915733446 21.822024285714285 21.0483 10.634708866699738 13.8391;11.9206;3.6768;14.4197;2.6193;28.2655;10.3235 9.31624;8.34831;1.12034;9.6236;0.978353;22.3101;7.4611 27.6952;21.0483;11.7489;29.0958;7.96997;38.3337;16.8623 0 0 Exp 4,2(0.29);Linear,1(0.15);Poly 2,4(0.58) 1.8725971250066504 13.261441588401794 1.530501127243042 2.3284006118774414 0.31283521131229614 1.8689792156219482 5.853498593442927 18.450644263699928 3.171367647754633 13.730930352245366 13.943721706193198 29.70032686523538 UP 1.0 0.0 0.0 GO:0007018 4 microtubule-based movement 28 32 2 2 2 2 2 2 67 30 2448 0.94609 0.21436 0.21436 6.25 293502;303575 kif22;kif18b KIF22_8963;KIF18B_32882 8.45795 8.45795 3.6768 6.761567173740124 8.399253675213677 6.761057619035142 5.070665 5.070665 1.12034 5.586603190781496 5.022168391608392 5.586182181884065 18.5919 18.5919 11.7489 9.677463407319093 18.507891142191145 9.676734109379016 0.5 8.45795 13.2391;3.6768 9.02099;1.12034 25.4349;11.7489 2 0 2 293502;303575 KIF22_8963;KIF18B_32882 8.45795 8.45795 6.761567173740124 5.070665 5.070665 5.586603190781496 18.5919 18.5919 9.677463407319093 13.2391;3.6768 9.02099;1.12034 25.4349;11.7489 0 0 Exp 4,1(0.5);Poly 2,1(0.5) 1.7383259444284234 3.4857853651046753 1.616806149482727 1.8689792156219482 0.17831328509964706 1.7428926825523376 -0.9131040000000006 17.829004 -2.6719719999999993 12.813302 5.179620000000002 32.00418 UP 1.0 0.0 0.0 GO:1903047 4 mitotic cell cycle process 136 146 11 11 11 9 9 9 60 137 2341 0.99486 0.015413 0.015413 6.16 360243;304477;293502;303575;361921;498709;306575;114851;58919 top2a;kntc1;kif22;kif18b;ect2;cks2;ckap2;cdkn1a;ccnd1 TOP2A_10059;KNTC1_8976;KIF22_8963;KIF18B_32882;ECT2_8523;CKS2_8325;CKAP2_8324;CDKN1A_8271;CCND1_8224 18.046932222222225 13.8391 3.6768 15.200772746848905 23.00944540994223 19.301097217530366 12.39859333333333 9.31624 1.12034 11.299944120312057 15.942038458669014 14.245556770364649 32.311344444444444 27.6952 11.7489 24.789158441550164 39.53812003989327 32.411381295093754 6.5 21.3426 13.8391;7.89839;13.2391;3.6768;14.4142;14.4197;12.1218;54.5478;28.2655 9.31624;3.83458;9.02099;1.12034;9.59235;9.6236;8.47044;38.2987;22.3101 27.6952;12.5679;25.4349;11.7489;30.0753;29.0958;21.3803;94.4701;38.3337 8 1 8 360243;304477;293502;303575;361921;498709;306575;58919 TOP2A_10059;KNTC1_8976;KIF22_8963;KIF18B_32882;ECT2_8523;CKS2_8325;CKAP2_8324;CCND1_8224 13.484323750000001 13.539100000000001 7.067586168190537 9.161079999999998 9.168614999999999 6.174167739919054 24.5415 26.56505 9.018586016665807 13.8391;7.89839;13.2391;3.6768;14.4142;14.4197;12.1218;28.2655 9.31624;3.83458;9.02099;1.12034;9.59235;9.6236;8.47044;22.3101 27.6952;12.5679;25.4349;11.7489;30.0753;29.0958;21.3803;38.3337 1 114851 CDKN1A_8271 54.5478 54.5478 38.2987 38.2987 94.4701 94.4701 54.5478 38.2987 94.4701 0 Exp 4,1(0.12);Exp 5,1(0.12);Linear,2(0.23);Poly 2,5(0.56) 1.8187392573133503 16.500335812568665 1.530501127243042 2.2675669193267822 0.2513138009283897 1.7797720432281494 8.115760694280937 27.978103750163505 5.015963174729456 19.781223491937208 16.115760929298336 48.506927959590556 UP 0.8888888888888888 0.1111111111111111 0.0 GO:1904486 5 response to 17alpha-ethynylestradiol 6 6 1 1 1 1 1 1 68 5 2473 0.98989 0.15206 0.15206 16.67 24777 slc10a1 SLC10A1_9832 7.96762 7.96762 7.96762 7.96762 6.07525 6.07525 6.07525 6.07525 11.4863 11.4863 11.4863 11.4863 0.0 7.96762 0.0 7.96762 7.96762 6.07525 11.4863 0 1 0 1 24777 SLC10A1_9832 7.96762 7.96762 6.07525 6.07525 11.4863 11.4863 7.96762 6.07525 11.4863 0 Poly 2,1(1) 2.4529356956481934 2.4529356956481934 2.4529356956481934 2.4529356956481934 0.0 2.4529356956481934 7.96762 7.96762 6.07525 6.07525 11.4863 11.4863 DOWN 0.0 1.0 0.0 GO:0051234 3 establishment of localization 596 632 23 22 21 22 20 20 49 612 1866 0.83078 0.24692 0.39957 3.16 24825;29503;24777;29692;314654;286918;290350;287167;293502;85430;24440;360504;24367;170568;114851;58919;287562;29657;25649;81639 tf;slc22a2;slc10a1;pla2g2a;myo1f;mx2;loxl2;hba-a1;kif22;herpud1;hbb;hba-a2;fgg;dmbt1;cdkn1a;ccnd1;ccl12;arntl;apoa2;alox15 TF_10003;SLC22A2_9845;SLC10A1_9832;PLA2G2A_32641;MYO1F_32715;MX2_9268;LOXL2_9150;LOC287167_9118;KIF22_8963;HERPUD1_8795;HBB_8782;HBA2_32600;FGG_8639;DMBT1_32993;CDKN1A_8271;CCND1_8224;CCL12_8217;ARNTL_8086;APOA2_33095;ALOX15_8036 57.13625600000006 54.2204 1.16694E-12 34.99608901855926 51.73276833095843 31.108135662912414 39.28696200000006 38.12495 1.16694E-12 25.6771624317814 35.57843389555007 22.71905573402544 123.75670000000007 106.393 1.16694E-12 96.14658355579 128.23834771394843 98.52203670496375 51.412;81.8219;7.96762;1.16694E-12;91.9576;31.6605;65.4434;105.203;13.2391;53.893;91.4283;101.406;93.1824;21.7434;54.5478;28.2655;25.5289;38.2177;80.183;105.624 36.6131;46.3605;6.07525;1.16694E-12;61.1322;23.5989;43.7615;82.0435;9.02099;37.9512;54.7263;84.6435;51.338;12.6557;38.2987;22.3101;13.9582;27.1236;50.2978;83.8302 86.0232;102.079;11.4863;1.16694E-12;110.707;46.786;129.393;130.247;25.4349;92.6554;277.036;115.953;327.378;160.485;94.4701;38.3337;336.862;63.2034;197.161;129.44 11 9 11 24825;29503;314654;287167;293502;85430;360504;170568;58919;25649;81639 TF_10003;SLC22A2_9845;MYO1F_32715;LOC287167_9118;KIF22_8963;HERPUD1_8795;HBA2_32600;DMBT1_32993;CCND1_8224;APOA2_33095;ALOX15_8036 66.79531818181819 80.183 34.64749844054598 47.89625363636364 46.3605 27.613415109711543 108.04719999999999 110.707 49.14610781014102 51.412;81.8219;91.9576;105.203;13.2391;53.893;101.406;21.7434;28.2655;80.183;105.624 36.6131;46.3605;61.1322;82.0435;9.02099;37.9512;84.6435;12.6557;22.3101;50.2978;83.8302 86.0232;102.079;110.707;130.247;25.4349;92.6554;115.953;160.485;38.3337;197.161;129.44 9 24777;29692;286918;290350;24440;24367;114851;287562;29657 SLC10A1_9832;PLA2G2A_32641;MX2_9268;LOXL2_9150;HBB_8782;FGG_8639;CDKN1A_8271;CCL12_8217;ARNTL_8086 45.330735555555684 38.2177 33.51250155202331 28.76449444444457 27.1236 19.65384810222338 142.95720000000014 94.4701 134.8393214328167 7.96762;1.16694E-12;31.6605;65.4434;91.4283;93.1824;54.5478;25.5289;38.2177 6.07525;1.16694E-12;23.5989;43.7615;54.7263;51.338;38.2987;13.9582;27.1236 11.4863;1.16694E-12;46.786;129.393;277.036;327.378;94.4701;336.862;63.2034 0 Exp 2,2(0.1);Hill,1(0.05);Linear,7(0.35);Poly 2,9(0.45);Power,1(0.05) 1.9162062862533207 39.98333239555359 1.5270863771438599 4.897102355957031 0.7479876861522715 1.7463279366493225 41.79854373754211 72.47396826245802 28.033449389313734 50.5404746106864 81.61860185951852 165.8947981404816 CONFLICT 0.55 0.45 0.0 GO:0048585 5 negative regulation of response to stimulus 377 396 19 19 15 18 14 14 55 382 2096 0.89497 0.17366 0.30997 3.54 29142;84386;287877;360918;85430;24367;116663;299691;84032;114851;24770;29657;25649;81639 vnn1;slpi;pycr1;pf4;herpud1;fgg;dusp6;cry1;col3a1;cdkn1a;ccl2;arntl;apoa2;alox15 VNN1_10157;SLPI_9890;PYCR1_9631;PF4_32963;HERPUD1_8795;FGG_8639;DUSP6_8506;CRY1_8386;COL3A1_8354;CDKN1A_8271;CCL2_8218;ARNTL_8086;APOA2_33095;ALOX15_8036 62.01839285714287 55.615750000000006 20.8684 25.558461309093023 59.71176998278829 23.12818866064653 40.948 38.858549999999994 17.1194 16.193874970066727 40.67229403945453 16.857364450859254 115.77046428571428 97.51915 26.5474 72.37161456198575 109.29909805507744 57.52647752319749 20.8684;56.5193;54.7122;105.82;53.893;93.1824;45.5478;37.2548;57.8774;54.5478;64.0097;38.2177;80.183;105.624 17.1194;39.3315;38.3856;53.8521;37.9512;51.338;33.3115;21.8798;39.4215;38.2987;41.1311;27.1236;50.2978;83.8302 26.5474;100.108;94.9303;109.875;92.6554;327.378;71.7388;73.8251;106.603;94.4701;132.851;63.2034;197.161;129.44 5 9 5 29142;287877;85430;25649;81639 VNN1_10157;PYCR1_9631;HERPUD1_8795;APOA2_33095;ALOX15_8036 63.05612000000001 54.7122 31.775548437942014 45.51684 38.3856 24.521823056779446 108.14682 94.9303 62.14911422226384 20.8684;54.7122;53.893;80.183;105.624 17.1194;38.3856;37.9512;50.2978;83.8302 26.5474;94.9303;92.6554;197.161;129.44 9 84386;360918;24367;116663;299691;84032;114851;24770;29657 SLPI_9890;PF4_32963;FGG_8639;DUSP6_8506;CRY1_8386;COL3A1_8354;CDKN1A_8271;CCL2_8218;ARNTL_8086 61.44187777777779 56.5193 23.571531158835292 38.40975555555556 39.3315 10.256130742891155 120.00582222222222 100.108 80.7676947013281 56.5193;105.82;93.1824;45.5478;37.2548;57.8774;54.5478;64.0097;38.2177 39.3315;53.8521;51.338;33.3115;21.8798;39.4215;38.2987;41.1311;27.1236 100.108;109.875;327.378;71.7388;73.8251;106.603;94.4701;132.851;63.2034 0 Exp 2,5(0.36);Exp 3,1(0.08);Linear,6(0.43);Poly 2,1(0.08);Power,1(0.08) 1.888219096288859 27.964232563972473 1.5270863771438599 4.897102355957031 0.8827304019645932 1.677998960018158 48.63005207989869 75.40673363438701 32.465129533685854 49.43087046631413 77.85989421510882 153.68103435631974 DOWN 0.35714285714285715 0.6428571428571429 0.0 GO:0031328 7 positive regulation of cellular biosynthetic process 404 436 18 18 16 16 14 14 55 422 2056 0.81057 0.28422 0.51578 3.21 360243;24825;78968;360918;362282;316351;114519;366960;24516;24309;306575;282840;29657;25649 top2a;tf;srebf1;pf4;pck1;npas2;nfil3;maff;jun;dbp;ckap2;atf5;arntl;apoa2 TOP2A_10059;TF_10003;SREBF1_32750;PF4_32963;PCK1_9439;NPAS2_9350;NFIL3_9304;MAFF_9172;JUN_8938;DBP_8439;CKAP2_8324;ATF5_8097;ARNTL_8086;APOA2_33095 48.15551928571428 51.0536 5.51457 31.771597589138178 58.337117532948994 27.487656388752335 31.997873571428574 36.20405 1.34064 20.948133395403634 39.75830265309593 19.470170966270985 78.84082857142857 74.61330000000001 21.3803 48.33032147798394 99.28593562233219 51.40855132390572 13.8391;51.412;11.2357;105.82;5.51457;58.2312;33.1149;58.0695;57.7663;50.6952;12.1218;97.9563;38.2177;80.183 9.31624;36.6131;4.94421;53.8521;1.34064;35.795;25.603;40.1293;38.6865;40.5862;8.47044;75.2121;27.1236;50.2978 27.6952;86.0232;24.5771;109.875;39.6721;99.4319;46.6318;104.733;109.049;59.5346;21.3803;114.804;63.2034;197.161 7 7 7 360243;24825;78968;362282;366960;306575;25649 TOP2A_10059;TF_10003;SREBF1_32750;PCK1_9439;MAFF_9172;CKAP2_8324;APOA2_33095 33.19652428571429 13.8391 29.51163513912993 21.58739 9.31624 20.01426098027854 71.60598571428572 39.6721 64.22821616624655 13.8391;51.412;11.2357;5.51457;58.0695;12.1218;80.183 9.31624;36.6131;4.94421;1.34064;40.1293;8.47044;50.2978 27.6952;86.0232;24.5771;39.6721;104.733;21.3803;197.161 7 360918;316351;114519;24516;24309;282840;29657 PF4_32963;NPAS2_9350;NFIL3_9304;JUN_8938;DBP_8439;ATF5_8097;ARNTL_8086 63.114514285714286 57.7663 28.17867480474249 42.40835714285714 38.6865 17.243344588454722 86.07567142857143 99.4319 28.522727301850306 105.82;58.2312;33.1149;57.7663;50.6952;97.9563;38.2177 53.8521;35.795;25.603;38.6865;40.5862;75.2121;27.1236 109.875;99.4319;46.6318;109.049;59.5346;114.804;63.2034 0 Exp 2,1(0.08);Exp 3,1(0.08);Hill,2(0.15);Linear,4(0.29);Poly 2,4(0.29);Power,2(0.15) 2.5575726276608792 39.1181036233902 1.5230457782745361 5.737884044647217 1.3452171050165465 2.2641037702560425 31.512538692453163 64.79849987897539 21.024570243303273 42.971176899553875 53.523857960572464 104.15779918228466 CONFLICT 0.5 0.5 0.0 GO:2000502 9 negative regulation of natural killer cell chemotaxis 1 1 1 1 1 1 1 1 68 0 2478 1.0 0.027091 0.027091 100.0 24770 ccl2 CCL2_8218 64.0097 64.0097 64.0097 64.0097 41.1311 41.1311 41.1311 41.1311 132.851 132.851 132.851 132.851 0.0 64.0097 0.0 64.0097 64.0097 41.1311 132.851 0 1 0 1 24770 CCL2_8218 64.0097 64.0097 41.1311 41.1311 132.851 132.851 64.0097 41.1311 132.851 0 Exp 2,1(1) 1.559963583946228 1.559963583946228 1.559963583946228 1.559963583946228 0.0 1.559963583946228 64.0097 64.0097 41.1311 41.1311 132.851 132.851 DOWN 0.0 1.0 0.0 GO:0007165 4 signal transduction 714 752 18 18 14 15 13 13 56 739 1739 0.029311 0.98553 0.060015 1.73 24825;78968;24777;360918;299923;24516;85430;361921;84032;114851;58919;24770;287562 tf;srebf1;slc10a1;pf4;ndrg1;jun;herpud1;ect2;col3a1;cdkn1a;ccnd1;ccl2;ccl12 TF_10003;SREBF1_32750;SLC10A1_9832;PF4_32963;NDRG1_32364;JUN_8938;HERPUD1_8795;ECT2_8523;COL3A1_8354;CDKN1A_8271;CCND1_8224;CCL2_8218;CCL12_8217 48.646324615384614 53.893 7.96762 30.986569773094885 48.987053369802005 30.314723146599814 29.64530076923077 37.9512 4.94421 16.12963601264014 29.10699811008375 14.689461833583453 98.32846923076923 94.4701 11.4863 81.59559271381622 119.26773737554663 102.93827450599707 51.412;11.2357;7.96762;105.82;99.6641;57.7663;53.893;14.4142;57.8774;54.5478;28.2655;64.0097;25.5289 36.6131;4.94421;6.07525;53.8521;42.5546;38.6865;37.9512;9.59235;39.4215;38.2987;22.3101;41.1311;13.9582 86.0232;24.5771;11.4863;109.875;105.409;109.049;92.6554;30.0753;106.603;94.4701;38.3337;132.851;336.862 5 8 5 24825;78968;85430;361921;58919 TF_10003;SREBF1_32750;HERPUD1_8795;ECT2_8523;CCND1_8224 31.844079999999998 28.2655 20.064711835384035 22.282192000000002 22.3101 15.104065880436634 54.332939999999994 38.3337 32.41412621208538 51.412;11.2357;53.893;14.4142;28.2655 36.6131;4.94421;37.9512;9.59235;22.3101 86.0232;24.5771;92.6554;30.0753;38.3337 8 24777;360918;299923;24516;84032;114851;24770;287562 SLC10A1_9832;PF4_32963;NDRG1_32364;JUN_8938;COL3A1_8354;CDKN1A_8271;CCL2_8218;CCL12_8217 59.1477275 57.82185 32.9888002868297 34.24724375 39.054 15.896768687814632 125.82567500000002 107.826 92.55468123458924 7.96762;105.82;99.6641;57.7663;57.8774;54.5478;64.0097;25.5289 6.07525;53.8521;42.5546;38.6865;39.4215;38.2987;41.1311;13.9582 11.4863;109.875;105.409;109.049;106.603;94.4701;132.851;336.862 0 Exp 2,3(0.24);Exp 3,2(0.16);Hill,1(0.08);Linear,4(0.31);Poly 2,3(0.24) 1.81596634746377 24.12065017223358 1.5226441621780396 2.857419490814209 0.42696756617419446 1.6645443439483643 31.80183340857179 65.49081582219745 20.87713075320282 38.41347078525872 53.97259976709089 142.68433869444763 DOWN 0.38461538461538464 0.6153846153846154 0.0 GO:0065009 3 regulation of molecular function 643 686 18 18 16 15 14 14 55 672 1806 0.12918 0.92252 0.27035 2.04 24825;84386;100911740;24516;85430;361921;116663;498709;114851;58919;24770;287562;25649;29339 tf;slpi;mrln;jun;herpud1;ect2;dusp6;cks2;cdkn1a;ccnd1;ccl2;ccl12;apoa2;apcs TF_10003;SLPI_9890;LOC100911740_32571;JUN_8938;HERPUD1_8795;ECT2_8523;DUSP6_8506;CKS2_8325;CDKN1A_8271;CCND1_8224;CCL2_8218;CCL12_8217;APOA2_33095;APCS_8057 52.81887142857143 54.2204 14.4142 26.51633080010616 53.718689322322376 25.627088560754324 34.58363214285714 38.12495 9.59235 15.578386420585401 35.13131008132131 15.023830690027003 141.95566428571428 97.28905 29.0958 115.79027177421061 158.70835367206706 124.05215115642137 51.412;56.5193;91.003;57.7663;53.893;14.4142;45.5478;14.4197;54.5478;28.2655;64.0097;25.5289;80.183;101.954 36.6131;39.3315;54.5666;38.6865;37.9512;9.59235;33.3115;9.6236;38.2987;22.3101;41.1311;13.9582;50.2978;58.4986 86.0232;100.108;273.335;109.049;92.6554;30.0753;71.7388;29.0958;94.4701;38.3337;132.851;336.862;197.161;395.621 6 8 6 24825;85430;361921;498709;58919;25649 TF_10003;HERPUD1_8795;ECT2_8523;CKS2_8325;CCND1_8224;APOA2_33095 40.43123333333333 39.83875 26.013420801014746 27.731358333333333 29.4616 16.60650092772155 78.89073333333333 62.17845 64.39805738777115 51.412;53.893;14.4142;14.4197;28.2655;80.183 36.6131;37.9512;9.59235;9.6236;22.3101;50.2978 86.0232;92.6554;30.0753;29.0958;38.3337;197.161 8 84386;100911740;24516;116663;114851;24770;287562;29339 SLPI_9890;LOC100911740_32571;JUN_8938;DUSP6_8506;CDKN1A_8271;CCL2_8218;CCL12_8217;APCS_8057 62.1096 57.1428 24.336194428640063 39.722837500000004 39.009 13.538447093891783 189.2543625 120.95 126.37813700681815 56.5193;91.003;57.7663;45.5478;54.5478;64.0097;25.5289;101.954 39.3315;54.5666;38.6865;33.3115;38.2987;41.1311;13.9582;58.4986 100.108;273.335;109.049;71.7388;94.4701;132.851;336.862;395.621 0 Exp 2,2(0.15);Linear,9(0.65);Poly 2,3(0.22) 1.6977042553765034 23.950579047203064 1.5230457782745361 2.2675669193267822 0.22923830997242328 1.6034149527549744 38.928767927401225 66.70897492974164 26.423174295412828 42.744089990301454 81.30101068763906 202.6103178837895 CONFLICT 0.42857142857142855 0.5714285714285714 0.0 GO:0010035 4 response to inorganic substance 271 293 17 16 15 15 14 14 55 279 2199 0.99015 0.022443 0.032506 4.78 24825;24587;290350;24516;24450;24440;360504;81660;24367;361921;25086;29680;58919;81639 tf;nefh;loxl2;jun;hmgcs2;hbb;hba-a2;gatm;fgg;ect2;cyp2e1;cyp11a1;ccnd1;alox15 TF_10003;NEFH_33218;LOXL2_9150;JUN_8938;HMGCS2_8812;HBB_8782;HBA2_32600;GATM_32792;FGG_8639;ECT2_8523;CYP2E1_8421;CYP11A1_32785;CCND1_8224;ALOX15_8036 60.68240714285714 54.589150000000004 14.4142 29.343310948637118 57.361149858398946 28.059639060522926 41.28695357142857 37.6498 9.59235 21.651505205007965 38.99029123407916 20.103669057354622 124.1821357142857 97.5361 30.0753 96.22111766939256 115.28923108402653 88.09055558879693 51.412;79.3182;65.4434;57.7663;30.5985;91.4283;101.406;37.423;93.1824;14.4142;49.5529;43.719;28.2655;105.624 36.6131;39.4261;43.7615;38.6865;24.577;54.7263;84.6435;28.03;51.338;9.59235;26.9979;33.4848;22.3101;83.8302 86.0232;264.141;129.393;109.049;40.5656;277.036;115.953;55.6613;327.378;30.0753;71.5977;63.9031;38.3337;129.44 8 6 8 24825;24450;360504;361921;25086;29680;58919;81639 TF_10003;HMGCS2_8812;HBA2_32600;ECT2_8523;CYP2E1_8421;CYP11A1_32785;CCND1_8224;ALOX15_8036 53.124012500000006 46.63595 33.41370770196983 40.256118750000006 30.24135 28.314569562000823 71.98644999999999 67.7504 36.59198164012753 51.412;30.5985;101.406;14.4142;49.5529;43.719;28.2655;105.624 36.6131;24.577;84.6435;9.59235;26.9979;33.4848;22.3101;83.8302 86.0232;40.5656;115.953;30.0753;71.5977;63.9031;38.3337;129.44 6 24587;290350;24516;24440;81660;24367 NEFH_33218;LOXL2_9150;JUN_8938;HBB_8782;GATM_32792;FGG_8639 70.76026666666667 72.3808 21.501830051013503 42.66139999999999 41.5938 9.616655152806535 193.77638333333334 196.767 109.66536445223558 79.3182;65.4434;57.7663;91.4283;37.423;93.1824 39.4261;43.7615;38.6865;54.7263;28.03;51.338 264.141;129.393;109.049;277.036;55.6613;327.378 0 Exp 2,6(0.43);Linear,4(0.29);Poly 2,4(0.29) 1.9417381080603577 27.72188639640808 1.5230457782745361 3.3687045574188232 0.4546714080194541 1.7789452075958252 45.311440879984964 76.05337340572933 29.945201557515635 52.62870558534152 73.77843191749989 174.58583951107153 CONFLICT 0.5714285714285714 0.42857142857142855 0.0 GO:0060627 5 regulation of vesicle-mediated transport 135 149 6 6 5 6 5 5 64 144 2334 0.78637 0.37838 0.59845 3.36 24825;24367;24770;25649;81639 tf;fgg;ccl2;apoa2;alox15 TF_10003;FGG_8639;CCL2_8218;APOA2_33095;ALOX15_8036 78.88222 80.183 51.412 21.77794074406484 81.39969151640678 21.2404099380902 52.642039999999994 50.2978 36.6131 18.502202320886035 56.03902486192334 19.768617116001483 174.57064 132.851 86.0232 94.17850842176257 163.93176717024042 72.81774508849178 51.412;93.1824;64.0097;80.183;105.624 36.6131;51.338;41.1311;50.2978;83.8302 86.0232;327.378;132.851;197.161;129.44 3 2 3 24825;25649;81639 TF_10003;APOA2_33095;ALOX15_8036 79.073 80.183 27.123040224134122 56.913700000000006 50.2978 24.29385174709846 137.54139999999998 129.44 56.01006301264089 51.412;80.183;105.624 36.6131;50.2978;83.8302 86.0232;197.161;129.44 2 24367;24770 FGG_8639;CCL2_8218 78.59604999999999 78.59604999999999 20.628213995520863 46.23455 46.23455 7.217368204892991 230.1145 230.1145 137.5513608238755 93.1824;64.0097 51.338;41.1311 327.378;132.851 0 Exp 2,2(0.4);Linear,2(0.4);Poly 2,1(0.2) 1.8188582332508156 9.136476635932922 1.559963583946228 2.0048909187316895 0.1929036483868787 1.9088982343673706 59.79301328183299 97.97142671816701 36.42414460780144 68.85993539219857 92.0195376345658 257.1217423654342 UP 0.6 0.4 0.0 GO:0070663 6 regulation of leukocyte proliferation 83 88 4 4 3 3 3 3 66 85 2393 0.78627 0.42914 0.5146 3.41 29692;114851;287562 pla2g2a;cdkn1a;ccl12 PLA2G2A_32641;CDKN1A_8271;CCL12_8217 26.69223333333372 25.5289 1.16694E-12 27.292501342737022 34.13844011255968 23.074866577500046 17.418966666667057 13.9582 1.16694E-12 19.38247365181526 22.139334147866812 17.36436962294964 143.77736666666706 94.4701 1.16694E-12 173.75962324603253 194.13717034008386 165.77695752727536 1.16694E-12;54.5478;25.5289 1.16694E-12;38.2987;13.9582 1.16694E-12;94.4701;336.862 0 3 0 3 29692;114851;287562 PLA2G2A_32641;CDKN1A_8271;CCL12_8217 26.69223333333372 25.5289 27.292501342737022 17.418966666667057 13.9582 19.38247365181526 143.77736666666706 94.4701 173.75962324603253 1.16694E-12;54.5478;25.5289 1.16694E-12;38.2987;13.9582 1.16694E-12;94.4701;336.862 0 Hill,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 1.7177729624107236 5.1843684911727905 1.5314651727676392 1.988358974456787 0.23498862623377384 1.6645443439483643 -4.192139340957667 57.57660600762511 -4.514367038988237 39.35230037232235 -52.85015723388722 340.40489056722134 DOWN 0.0 1.0 0.0 GO:1905952 5 regulation of lipid localization 57 62 4 4 4 4 4 4 65 58 2420 0.9753 0.085045 0.085045 6.45 78968;58827;299691;25649 srebf1;mest;cry1;apoa2 SREBF1_32750;MEST_9219;CRY1_8386;APOA2_33095 56.39767500000001 58.718900000000005 11.2357 39.2157589103645 61.342433226768975 32.18545158853902 33.4642775 36.0888 4.94421 24.30707947016037 37.04934473273657 20.142069539151628 156.7638 135.49305 24.5771 137.2516293256781 160.05488375106563 114.80628224005531 2.5 88.5501 11.2357;96.9172;37.2548;80.183 4.94421;56.7353;21.8798;50.2978 24.5771;331.492;73.8251;197.161 2 2 2 78968;25649 SREBF1_32750;APOA2_33095 45.70935 45.70935 48.75310337450326 27.621005 27.621005 32.06983104015439 110.86905 110.86905 122.03524601362099 11.2357;80.183 4.94421;50.2978 24.5771;197.161 2 58827;299691 MEST_9219;CRY1_8386 67.086 67.086 42.18768762186427 39.30755 39.30755 24.64656041164772 202.65855000000002 202.65855000000002 182.19801227731605 96.9172;37.2548 56.7353;21.8798 331.492;73.8251 0 Exp 2,1(0.25);Hill,1(0.25);Linear,2(0.5) 2.1405565004764098 8.692407846450806 1.8622472286224365 2.857419490814209 0.46011390271348673 1.98637056350708 17.966231267842787 94.82911873215723 9.643339619242838 57.285215380757165 22.257203260835496 291.27039673916454 CONFLICT 0.5 0.5 0.0 GO:0003062 7 regulation of heart rate by chemical signal 1 1 1 1 1 1 1 1 68 0 2478 1.0 0.027091 0.027091 100.0 78968 srebf1 SREBF1_32750 11.2357 11.2357 11.2357 11.2357 4.94421 4.94421 4.94421 4.94421 24.5771 24.5771 24.5771 24.5771 0.0 11.2357 0.0 11.2357 11.2357 4.94421 24.5771 1 0 1 78968 SREBF1_32750 11.2357 11.2357 4.94421 4.94421 24.5771 24.5771 11.2357 4.94421 24.5771 0 0 Hill,1(1) 2.857419490814209 2.857419490814209 2.857419490814209 2.857419490814209 0.0 2.857419490814209 11.2357 11.2357 4.94421 4.94421 24.5771 24.5771 UP 1.0 0.0 0.0 GO:0031667 5 response to nutrient levels 239 256 17 17 17 13 13 13 56 243 2235 0.99277 0.017574 0.022966 5.08 78968;24777;25044;362282;24516;79438;24450;81660;29680;114851;58919;24770;25612 srebf1;slc10a1;sds;pck1;jun;igfals;hmgcs2;gatm;cyp11a1;cdkn1a;ccnd1;ccl2;asns SREBF1_32750;SLC10A1_9832;SDS_9798;PCK1_9439;JUN_8938;IGFALS_8880;HMGCS2_8812;GATM_32792;CYP11A1_32785;CDKN1A_8271;CCND1_8224;CCL2_8218;ASNS_8091 43.2167376923077 43.719 5.51457 25.622028956373374 46.888294808396424 22.638246968140695 29.388399999999997 33.4848 1.34064 16.80488230903498 32.37443915166936 14.022370081575662 85.43702307692307 63.9031 11.4863 61.100663729116654 89.36615609873401 59.295732172088705 11.5 78.01525 11.2357;7.96762;64.7394;5.51457;57.7663;70.3663;30.5985;37.423;43.719;54.5478;28.2655;64.0097;85.6642 4.94421;6.07525;43.4259;1.34064;38.6865;46.0459;24.577;28.03;33.4848;38.2987;22.3101;41.1311;53.6991 24.5771;11.4863;126.828;39.6721;109.049;148.796;40.5656;55.6613;63.9031;94.4701;38.3337;132.851;224.488 6 7 6 78968;362282;24450;29680;58919;25612 SREBF1_32750;PCK1_9439;HMGCS2_8812;CYP11A1_32785;CCND1_8224;ASNS_8091 34.166244999999996 29.432000000000002 28.766544691758686 23.392641666666663 23.443550000000002 19.23300853284937 71.92326666666666 40.11885 75.80722977058763 11.2357;5.51457;30.5985;43.719;28.2655;85.6642 4.94421;1.34064;24.577;33.4848;22.3101;53.6991 24.5771;39.6721;40.5656;63.9031;38.3337;224.488 7 24777;25044;24516;79438;81660;114851;24770 SLC10A1_9832;SDS_9798;JUN_8938;IGFALS_8880;GATM_32792;CDKN1A_8271;CCL2_8218 50.97430285714285 57.7663 21.708534104250123 34.52762142857143 38.6865 13.776367813090195 97.02024285714285 109.049 48.3578437846043 7.96762;64.7394;57.7663;70.3663;37.423;54.5478;64.0097 6.07525;43.4259;38.6865;46.0459;28.03;38.2987;41.1311 11.4863;126.828;109.049;148.796;55.6613;94.4701;132.851 0 Exp 2,6(0.47);Hill,2(0.16);Linear,4(0.31);Poly 2,1(0.08) 2.0125248634472794 27.016669034957886 1.5230457782745361 3.3687045574188232 0.5734596744856074 1.9179565906524658 29.28844409231465 57.14503129230073 20.253161915923688 38.52363808407631 52.222323920090965 118.65172223375515 CONFLICT 0.46153846153846156 0.5384615384615384 0.0 GO:0019222 4 regulation of metabolic process 1092 1179 40 40 34 36 32 32 37 1147 1331 0.55558 0.5417 1.0 2.71 360243;24825;78968;84386;24777;29692;360918;362282;316351;114519;366960;290350;24516;85430;24440;81660;24367;361921;116663;24309;299691;498709;306575;114851;58919;24770;287562;282840;29657;25649;29339;81639 top2a;tf;srebf1;slpi;slc10a1;pla2g2a;pf4;pck1;npas2;nfil3;maff;loxl2;jun;herpud1;hbb;gatm;fgg;ect2;dusp6;dbp;cry1;cks2;ckap2;cdkn1a;ccnd1;ccl2;ccl12;atf5;arntl;apoa2;apcs;alox15 TOP2A_10059;TF_10003;SREBF1_32750;SLPI_9890;SLC10A1_9832;PLA2G2A_32641;PF4_32963;PCK1_9439;NPAS2_9350;NFIL3_9304;MAFF_9172;LOXL2_9150;JUN_8938;HERPUD1_8795;HBB_8782;GATM_32792;FGG_8639;ECT2_8523;DUSP6_8506;DBP_8439;CRY1_8386;CKS2_8325;CKAP2_8324;CDKN1A_8271;CCND1_8224;CCL2_8218;CCL12_8217;ATF5_8097;ARNTL_8086;APOA2_33095;APCS_8057;ALOX15_8036 49.112521562500035 51.0536 1.16694E-12 31.746550776897614 53.39454040819228 28.792299361915667 32.55056656250003 36.20405 1.16694E-12 20.916696740008586 36.0918237134561 19.964703656276512 107.18132500000006 89.33930000000001 1.16694E-12 98.27867014802604 122.14120159273452 102.12339330893045 13.8391;51.412;11.2357;56.5193;7.96762;1.16694E-12;105.82;5.51457;58.2312;33.1149;58.0695;65.4434;57.7663;53.893;91.4283;37.423;93.1824;14.4142;45.5478;50.6952;37.2548;14.4197;12.1218;54.5478;28.2655;64.0097;25.5289;97.9563;38.2177;80.183;101.954;105.624 9.31624;36.6131;4.94421;39.3315;6.07525;1.16694E-12;53.8521;1.34064;35.795;25.603;40.1293;43.7615;38.6865;37.9512;54.7263;28.03;51.338;9.59235;33.3115;40.5862;21.8798;9.6236;8.47044;38.2987;22.3101;41.1311;13.9582;75.2121;27.1236;50.2978;58.4986;83.8302 27.6952;86.0232;24.5771;100.108;11.4863;1.16694E-12;109.875;39.6721;99.4319;46.6318;104.733;129.393;109.049;92.6554;277.036;55.6613;327.378;30.0753;71.7388;59.5346;73.8251;29.0958;21.3803;94.4701;38.3337;132.851;336.862;114.804;63.2034;197.161;395.621;129.44 12 20 12 360243;24825;78968;362282;366960;85430;361921;498709;306575;58919;25649;81639 TOP2A_10059;TF_10003;SREBF1_32750;PCK1_9439;MAFF_9172;HERPUD1_8795;ECT2_8523;CKS2_8325;CKAP2_8324;CCND1_8224;APOA2_33095;ALOX15_8036 37.41600583333334 21.3426 32.21478279922616 26.201598333333333 15.966849999999999 24.452941955224507 68.40350833333333 39.0029 54.81814726651713 13.8391;51.412;11.2357;5.51457;58.0695;53.893;14.4142;14.4197;12.1218;28.2655;80.183;105.624 9.31624;36.6131;4.94421;1.34064;40.1293;37.9512;9.59235;9.6236;8.47044;22.3101;50.2978;83.8302 27.6952;86.0232;24.5771;39.6721;104.733;92.6554;30.0753;29.0958;21.3803;38.3337;197.161;129.44 20 84386;24777;29692;360918;316351;114519;290350;24516;24440;81660;24367;116663;24309;299691;114851;24770;287562;282840;29657;29339 SLPI_9890;SLC10A1_9832;PLA2G2A_32641;PF4_32963;NPAS2_9350;NFIL3_9304;LOXL2_9150;JUN_8938;HBB_8782;GATM_32792;FGG_8639;DUSP6_8506;DBP_8439;CRY1_8386;CDKN1A_8271;CCL2_8218;CCL12_8217;ATF5_8097;ARNTL_8086;APCS_8057 56.13043100000006 55.533550000000005 30.08821303961599 36.35994750000006 38.492599999999996 18.080818233052923 130.44801500000005 99.76995 111.80172279168933 56.5193;7.96762;1.16694E-12;105.82;58.2312;33.1149;65.4434;57.7663;91.4283;37.423;93.1824;45.5478;50.6952;37.2548;54.5478;64.0097;25.5289;97.9563;38.2177;101.954 39.3315;6.07525;1.16694E-12;53.8521;35.795;25.603;43.7615;38.6865;54.7263;28.03;51.338;33.3115;40.5862;21.8798;38.2987;41.1311;13.9582;75.2121;27.1236;58.4986 100.108;11.4863;1.16694E-12;109.875;99.4319;46.6318;129.393;109.049;277.036;55.6613;327.378;71.7388;59.5346;73.8251;94.4701;132.851;336.862;114.804;63.2034;395.621 0 Exp 2,5(0.16);Exp 3,1(0.04);Hill,3(0.1);Linear,12(0.38);Poly 2,9(0.29);Power,2(0.07) 2.0802382900139422 71.33337235450745 1.5230457782745361 5.737884044647217 1.0279365134009304 1.8783162832260132 38.112902909022644 60.112140215977455 25.303300891107554 39.79783223389252 73.1295030872441 141.23314691275596 DOWN 0.375 0.625 0.0 GO:1901988 8 negative regulation of cell cycle phase transition 40 41 5 5 4 4 4 4 65 37 2441 0.99557 0.023498 0.023498 9.76 114851;58919;24770;282840 cdkn1a;ccnd1;ccl2;atf5 CDKN1A_8271;CCND1_8224;CCL2_8218;ATF5_8097 61.194824999999994 59.27875 28.2655 28.79729704762527 62.68743094138543 30.461358709446763 44.238 39.7149 22.3101 22.24976240562283 46.18657034537202 23.762280492137403 95.1147 104.63705 38.3337 40.97232538490666 91.4084367515295 37.35609504377408 1.5 59.27875 54.5478;28.2655;64.0097;97.9563 38.2987;22.3101;41.1311;75.2121 94.4701;38.3337;132.851;114.804 1 3 1 58919 CCND1_8224 28.2655 28.2655 22.3101 22.3101 38.3337 38.3337 28.2655 22.3101 38.3337 3 114851;24770;282840 CDKN1A_8271;CCL2_8218;ATF5_8097 72.17126666666667 64.0097 22.826143912262832 51.54730000000001 41.1311 20.543190884572905 114.04169999999999 114.804 19.20180192507992 54.5478;64.0097;97.9563 38.2987;41.1311;75.2121 94.4701;132.851;114.804 0 Exp 2,1(0.25);Linear,2(0.5);Poly 2,1(0.25) 1.9360203504187163 7.878070950508118 1.559963583946228 2.385996103286743 0.4175447758119513 1.9660556316375732 32.97347389332724 89.41617610667275 22.43323284248963 66.04276715751037 54.96182112279147 135.26757887720854 DOWN 0.25 0.75 0.0 GO:0002684 5 positive regulation of immune system process 239 264 7 7 7 7 7 7 62 257 2221 0.57486 0.58414 1.0 2.65 29142;360918;24516;114851;24770;287562;29339 vnn1;pf4;jun;cdkn1a;ccl2;ccl12;apcs VNN1_10157;PF4_32963;JUN_8938;CDKN1A_8271;CCL2_8218;CCL12_8217;APCS_8057 61.4993 57.7663 20.8684 33.20192680392711 58.662568361360975 31.702019531623776 37.36351428571429 38.6865 13.9582 16.79790548783078 36.0938868726372 17.619728360473598 172.1822142857143 109.875 26.5474 137.66379985218128 217.61101016816585 146.19269544400228 20.8684;105.82;57.7663;54.5478;64.0097;25.5289;101.954 17.1194;53.8521;38.6865;38.2987;41.1311;13.9582;58.4986 26.5474;109.875;109.049;94.4701;132.851;336.862;395.621 1 6 1 29142 VNN1_10157 20.8684 20.8684 17.1194 17.1194 26.5474 26.5474 20.8684 17.1194 26.5474 6 360918;24516;114851;24770;287562;29339 PF4_32963;JUN_8938;CDKN1A_8271;CCL2_8218;CCL12_8217;APCS_8057 68.27111666666667 60.888 30.620883789820056 40.73753333333334 39.9088 15.58774892185098 196.4546833333333 121.363 133.38929123764652 105.82;57.7663;54.5478;64.0097;25.5289;101.954 53.8521;38.6865;38.2987;41.1311;13.9582;58.4986 109.875;109.049;94.4701;132.851;336.862;395.621 0 Exp 2,3(0.43);Exp 3,1(0.15);Linear,2(0.29);Poly 2,1(0.15) 1.7376296352369234 12.385594964027405 1.5230457782745361 2.642244338989258 0.39999550830319497 1.6244933605194092 36.90296841601901 86.09563158398099 24.91945175479543 49.807576816633144 70.1994441811025 274.164984390326 DOWN 0.14285714285714285 0.8571428571428571 0.0 GO:0016477 4 cell migration 189 200 6 6 6 5 5 5 64 195 2283 0.53924 0.6419 1.0 2.5 360918;290350;24770;287562;289054 pf4;loxl2;ccl2;ccl12;aspm PF4_32963;LOXL2_9150;CCL2_8218;CCL12_8217;ASPM_8092 54.2251 64.0097 10.3235 37.531469246020734 46.3736204996449 30.73728838927707 32.0328 41.1311 7.4611 20.167318395860168 28.22426405982371 18.49173148485045 145.16866 129.393 16.8623 117.10582527068414 198.5118542549192 132.0113867257773 105.82;65.4434;64.0097;25.5289;10.3235 53.8521;43.7615;41.1311;13.9582;7.4611 109.875;129.393;132.851;336.862;16.8623 1 4 1 289054 ASPM_8092 10.3235 10.3235 7.4611 7.4611 16.8623 16.8623 10.3235 7.4611 16.8623 4 360918;290350;24770;287562 PF4_32963;LOXL2_9150;CCL2_8218;CCL12_8217 65.2005 64.72655 32.78849712861711 38.175725 42.4463 17.050634142728146 177.24525 131.122 106.89082394161191 105.82;65.4434;64.0097;25.5289 53.8521;43.7615;41.1311;13.9582 109.875;129.393;132.851;336.862 0 Exp 2,1(0.2);Exp 3,1(0.2);Linear,1(0.2);Poly 2,2(0.4) 1.6382461439976619 8.213896751403809 1.5314651727676392 1.8398383855819702 0.13832018801149337 1.559963583946228 21.327316720418303 87.12288327958169 14.35536601604607 49.710233983953934 42.52087834034673 247.81644165965326 DOWN 0.2 0.8 0.0 GO:0009628 3 response to abiotic stimulus 422 443 19 18 16 17 15 15 54 428 2050 0.86875 0.20706 0.3343 3.39 360243;24825;362282;299923;290350;24516;24450;361921;29680;299691;84032;114851;58919;24770;25612 top2a;tf;pck1;ndrg1;loxl2;jun;hmgcs2;ect2;cyp11a1;cry1;col3a1;cdkn1a;ccnd1;ccl2;asns TOP2A_10059;TF_10003;PCK1_9439;NDRG1_32364;LOXL2_9150;JUN_8938;HMGCS2_8812;ECT2_8523;CYP11A1_32785;CRY1_8386;COL3A1_8354;CDKN1A_8271;CCND1_8224;CCL2_8218;ASNS_8091 47.332704666666665 51.412 5.51457 26.477979404371617 52.95108659598476 26.198771611856174 30.44446866666667 36.6131 1.34064 14.973018006818068 32.91659031139488 12.799606939421404 86.82376 86.0232 27.6952 52.302053114164245 91.63999481100272 50.06714974633193 13.8391;51.412;5.51457;99.6641;65.4434;57.7663;30.5985;14.4142;43.719;37.2548;57.8774;54.5478;28.2655;64.0097;85.6642 9.31624;36.6131;1.34064;42.5546;43.7615;38.6865;24.577;9.59235;33.4848;21.8798;39.4215;38.2987;22.3101;41.1311;53.6991 27.6952;86.0232;39.6721;105.409;129.393;109.049;40.5656;30.0753;63.9031;73.8251;106.603;94.4701;38.3337;132.851;224.488 8 7 8 360243;24825;362282;24450;361921;29680;58919;25612 TOP2A_10059;TF_10003;PCK1_9439;HMGCS2_8812;ECT2_8523;CYP11A1_32785;CCND1_8224;ASNS_8091 34.17838375 29.432000000000002 25.946405106837286 23.86666625 23.443550000000002 17.19956192643367 68.844525 40.11885 65.81616610207881 13.8391;51.412;5.51457;30.5985;14.4142;43.719;28.2655;85.6642 9.31624;36.6131;1.34064;24.577;9.59235;33.4848;22.3101;53.6991 27.6952;86.0232;39.6721;40.5656;30.0753;63.9031;38.3337;224.488 7 299923;290350;24516;299691;84032;114851;24770 NDRG1_32364;LOXL2_9150;JUN_8938;CRY1_8386;COL3A1_8354;CDKN1A_8271;CCL2_8218 62.36621428571429 57.8774 18.869383448983214 37.961957142857145 39.4215 7.373092228243888 107.37145714285715 106.603 20.137918057556394 99.6641;65.4434;57.7663;37.2548;57.8774;54.5478;64.0097 42.5546;43.7615;38.6865;21.8798;39.4215;38.2987;41.1311 105.409;129.393;109.049;73.8251;106.603;94.4701;132.851 0 Exp 2,7(0.47);Exp 3,1(0.07);Hill,1(0.07);Linear,4(0.27);Poly 2,2(0.14) 1.8537342695676071 28.46820104122162 1.5226441621780396 3.3687045574188232 0.4788040820872587 1.752767562866211 33.932998292151055 60.732411041182274 22.867076080638302 38.02186125269503 60.35526919067445 113.29225080932554 CONFLICT 0.5333333333333333 0.4666666666666667 0.0 GO:0051049 5 regulation of transport 454 483 15 15 14 14 13 13 56 470 2008 0.56327 0.56036 1.0 2.69 24825;78968;24777;24587;286918;100911740;24367;361921;299691;24770;29657;25649;81639 tf;srebf1;slc10a1;nefh;mx2;mrln;fgg;ect2;cry1;ccl2;arntl;apoa2;alox15 TF_10003;SREBF1_32750;SLC10A1_9832;NEFH_33218;MX2_9268;LOC100911740_32571;FGG_8639;ECT2_8523;CRY1_8386;CCL2_8218;ARNTL_8086;APOA2_33095;ALOX15_8036 54.26790923076923 51.412 7.96762 33.59734148043723 54.54545762486839 31.16492408462525 34.64746230769231 36.6131 4.94421 22.501968653821212 35.45830386858112 21.83855456611438 127.71403076923077 86.0232 11.4863 105.50208437545506 119.47869901011813 91.83083840320467 51.412;11.2357;7.96762;79.3182;31.6605;91.003;93.1824;14.4142;37.2548;64.0097;38.2177;80.183;105.624 36.6131;4.94421;6.07525;39.4261;23.5989;54.5666;51.338;9.59235;21.8798;41.1311;27.1236;50.2978;83.8302 86.0232;24.5771;11.4863;264.141;46.786;273.335;327.378;30.0753;73.8251;132.851;63.2034;197.161;129.44 5 8 5 24825;78968;361921;25649;81639 TF_10003;SREBF1_32750;ECT2_8523;APOA2_33095;ALOX15_8036 52.57378 51.412 41.057688097626745 37.05553200000001 36.6131 32.20553656019985 93.45532 86.0232 72.22575335749016 51.412;11.2357;14.4142;80.183;105.624 36.6131;4.94421;9.59235;50.2978;83.8302 86.0232;24.5771;30.0753;197.161;129.44 8 24777;24587;286918;100911740;24367;299691;24770;29657 SLC10A1_9832;NEFH_33218;MX2_9268;LOC100911740_32571;FGG_8639;CRY1_8386;CCL2_8218;ARNTL_8086 55.32674 51.113699999999994 31.119864801656373 33.14241875 33.27485 16.388853058229586 149.125725 103.33805000000001 121.40019909495031 7.96762;79.3182;31.6605;91.003;93.1824;37.2548;64.0097;38.2177 6.07525;39.4261;23.5989;54.5666;51.338;21.8798;41.1311;27.1236 11.4863;264.141;46.786;273.335;327.378;73.8251;132.851;63.2034 0 Exp 2,5(0.39);Hill,1(0.08);Linear,3(0.24);Poly 2,3(0.24);Power,1(0.08) 2.1363293035323454 29.225581526756287 1.559963583946228 4.897102355957031 0.8858975160772214 1.9088982343673706 36.004186357161565 72.53163210437691 22.415252808518296 46.87967180686632 70.36244440209988 185.06561713636165 DOWN 0.38461538461538464 0.6153846153846154 0.0 GO:0021953 6 central nervous system neuron differentiation 21 22 2 2 2 2 2 2 67 20 2458 0.97973 0.1181 0.1181 9.09 360243;282840 top2a;atf5 TOP2A_10059;ATF5_8097 55.8977 55.8977 13.8391 59.47984253442506 82.40456134384071 46.180345075765835 42.26417000000001 42.26417000000001 9.31624 46.59540945811936 63.029155331812525 36.176828922792865 71.2496 71.2496 27.6952 61.59522318102273 98.69916897552882 47.822733556702694 0.5 55.8977 13.8391;97.9563 9.31624;75.2121 27.6952;114.804 1 1 1 360243 TOP2A_10059 13.8391 13.8391 9.31624 9.31624 27.6952 27.6952 13.8391 9.31624 27.6952 1 282840 ATF5_8097 97.9563 97.9563 75.2121 75.2121 114.804 114.804 97.9563 75.2121 114.804 0 Poly 2,2(1) 2.126028229865479 4.280381441116333 1.8943853378295898 2.385996103286743 0.34762130595906243 2.1401907205581665 -26.53715599999998 138.33255599999998 -22.313772800000002 106.8421128 -14.117024 156.616224 CONFLICT 0.5 0.5 0.0 GO:0032501 2 multicellular organismal process 609 640 22 22 19 18 16 16 53 624 1854 0.41512 0.69155 0.77965 2.5 316351;366960;25087;24516;24450;24440;360504;81660;24367;299691;24770;282840;289054;29657;25649;81639 npas2;maff;kng2l1;jun;hmgcs2;hbb;hba-a2;gatm;fgg;cry1;ccl2;atf5;aspm;arntl;apoa2;alox15 NPAS2_9350;MAFF_9172;KNG2_8975;JUN_8938;HMGCS2_8812;HBB_8782;HBA2_32600;GATM_32792;FGG_8639;CRY1_8386;CCL2_8218;ATF5_8097;ASPM_8092;ARNTL_8086;APOA2_33095;ALOX15_8036 64.72569375 61.12045 10.3235 28.788228489609384 61.676943758235474 27.459871638226307 44.84524375 40.6302 7.4611 22.128375717163657 43.02590196046979 21.23548229696095 124.87316249999999 111.9265 16.8623 82.12136561232508 111.11946844571753 66.31753411736676 58.2312;58.0695;73.9369;57.7663;30.5985;91.4283;101.406;37.423;93.1824;37.2548;64.0097;97.9563;10.3235;38.2177;80.183;105.624 35.795;40.1293;52.6626;38.6865;24.577;54.7263;84.6435;28.03;51.338;21.8798;41.1311;75.2121;7.4611;27.1236;50.2978;83.8302 99.4319;104.733;140.016;109.049;40.5656;277.036;115.953;55.6613;327.378;73.8251;132.851;114.804;16.8623;63.2034;197.161;129.44 7 9 7 366960;25087;24450;360504;289054;25649;81639 MAFF_9172;KNG2_8975;HMGCS2_8812;HBA2_32600;ASPM_8092;APOA2_33095;ALOX15_8036 65.73448571428571 73.9369 35.36320187829098 49.085928571428575 50.2978 28.57534374991338 106.39012857142858 115.953 61.02409652142107 58.0695;73.9369;30.5985;101.406;10.3235;80.183;105.624 40.1293;52.6626;24.577;84.6435;7.4611;50.2978;83.8302 104.733;140.016;40.5656;115.953;16.8623;197.161;129.44 9 316351;24516;24440;81660;24367;299691;24770;282840;29657 NPAS2_9350;JUN_8938;HBB_8782;GATM_32792;FGG_8639;CRY1_8386;CCL2_8218;ATF5_8097;ARNTL_8086 63.941077777777764 58.2312 24.787675824983 41.546933333333335 38.6865 16.665383422381854 139.24885555555554 109.049 96.54263012594632 58.2312;57.7663;91.4283;37.423;93.1824;37.2548;64.0097;97.9563;38.2177 35.795;38.6865;54.7263;28.03;51.338;21.8798;41.1311;75.2121;27.1236 99.4319;109.049;277.036;55.6613;327.378;73.8251;132.851;114.804;63.2034 0 Exp 2,7(0.44);Linear,3(0.19);Poly 2,4(0.25);Power,2(0.13) 2.1187082557842993 36.68162131309509 1.5230457782745361 4.897102355957031 1.0979486929142956 1.8419257402420044 50.6194617900914 78.8319257099086 34.0023396485898 55.688147851410186 84.63369334996074 165.1126316500393 CONFLICT 0.4375 0.5625 0.0 GO:0002761 7 regulation of myeloid leukocyte differentiation 45 48 3 3 3 3 3 3 66 45 2433 0.96078 0.13911 0.13911 6.25 360918;24516;29339 pf4;jun;apcs PF4_32963;JUN_8938;APCS_8057 88.51343333333334 101.954 57.7663 26.697867801817594 86.7771126413223 26.402737867853194 50.345733333333335 53.8521 38.6865 10.361022247024339 50.85445455206612 11.207737881628969 204.84833333333333 109.875 109.049 165.2144918865574 256.29937302479334 175.28879392616787 1.5 103.887 105.82;57.7663;101.954 53.8521;38.6865;58.4986 109.875;109.049;395.621 0 3 0 3 360918;24516;29339 PF4_32963;JUN_8938;APCS_8057 88.51343333333334 101.954 26.697867801817594 50.345733333333335 53.8521 10.361022247024339 204.84833333333333 109.875 165.2144918865574 105.82;57.7663;101.954 53.8521;38.6865;58.4986 109.875;109.049;395.621 0 Exp 2,1(0.34);Exp 3,1(0.34);Linear,1(0.34) 1.6573091360833927 4.9873775243759155 1.5230457782745361 1.8398383855819702 0.16177280766925747 1.6244933605194092 58.301951855483104 118.72491481118354 38.621132925870896 62.070333740795775 17.890535858460282 391.8061308082064 DOWN 0.0 1.0 0.0 GO:0006950 3 response to stress 773 821 44 43 41 42 40 40 29 781 1697 1.0 7.1463E-6 1.0089E-5 4.87 29142;360847;360243;24825;78968;84386;287877;29692;360918;362282;338475;24587;299923;314654;286918;290350;100911740;293502;24516;24450;85430;24440;360504;81660;361921;116663;170568;25086;29680;299691;84032;114851;58919;24770;287562;25612;29657;25649;29339;81639 vnn1;ube2t;top2a;tf;srebf1;slpi;pycr1;pla2g2a;pf4;pck1;nrep;nefh;ndrg1;myo1f;mx2;loxl2;mrln;kif22;jun;hmgcs2;herpud1;hbb;hba-a2;gatm;ect2;dusp6;dmbt1;cyp2e1;cyp11a1;cry1;col3a1;cdkn1a;ccnd1;ccl2;ccl12;asns;arntl;apoa2;apcs;alox15 VNN1_10157;UBE2T_10125;TOP2A_10059;TF_10003;SREBF1_32750;SLPI_9890;PYCR1_9631;PLA2G2A_32641;PF4_32963;PCK1_9439;NREP_9364;NEFH_33218;NDRG1_32364;MYO1F_32715;MX2_9268;LOXL2_9150;LOC100911740_32571;KIF22_8963;JUN_8938;HMGCS2_8812;HERPUD1_8795;HBB_8782;HBA2_32600;GATM_32792;ECT2_8523;DUSP6_8506;DMBT1_32993;CYP2E1_8421;CYP11A1_32785;CRY1_8386;COL3A1_8354;CDKN1A_8271;CCND1_8224;CCL2_8218;CCL12_8217;ASNS_8091;ARNTL_8086;APOA2_33095;APCS_8057;ALOX15_8036 51.666974250000024 50.48245 1.16694E-12 31.3452540857293 53.202545228193024 28.923098745840107 33.64920850000003 35.048950000000005 1.16694E-12 20.278911952443334 34.27085861917406 17.898306812020394 110.44957750000003 93.56275 1.16694E-12 91.44384088241226 121.94137428990969 98.32523410919157 20.8684;10.9914;13.8391;51.412;11.2357;56.5193;54.7122;1.16694E-12;105.82;5.51457;36.861;79.3182;99.6641;91.9576;31.6605;65.4434;91.003;13.2391;57.7663;30.5985;53.893;91.4283;101.406;37.423;14.4142;45.5478;21.7434;49.5529;43.719;37.2548;57.8774;54.5478;28.2655;64.0097;25.5289;85.6642;38.2177;80.183;101.954;105.624 17.1194;7.86591;9.31624;36.6131;4.94421;39.3315;38.3856;1.16694E-12;53.8521;1.34064;28.0333;39.4261;42.5546;61.1322;23.5989;43.7615;54.5666;9.02099;38.6865;24.577;37.9512;54.7263;84.6435;28.03;9.59235;33.3115;12.6557;26.9979;33.4848;21.8798;39.4215;38.2987;22.3101;41.1311;13.9582;53.6991;27.1236;50.2978;58.4986;83.8302 26.5474;18.2059;27.6952;86.0232;24.5771;100.108;94.9303;1.16694E-12;109.875;39.6721;53.5645;264.141;105.409;110.707;46.786;129.393;273.335;25.4349;109.049;40.5656;92.6554;277.036;115.953;55.6613;30.0753;71.7388;160.485;71.5977;63.9031;73.8251;106.603;94.4701;38.3337;132.851;336.862;224.488;63.2034;197.161;395.621;129.44 20 20 20 29142;360847;360243;24825;78968;287877;362282;314654;293502;24450;85430;360504;361921;170568;25086;29680;58919;25612;25649;81639 VNN1_10157;UBE2T_10125;TOP2A_10059;TF_10003;SREBF1_32750;PYCR1_9631;PCK1_9439;MYO1F_32715;KIF22_8963;HMGCS2_8812;HERPUD1_8795;HBA2_32600;ECT2_8523;DMBT1_32993;CYP2E1_8421;CYP11A1_32785;CCND1_8224;ASNS_8091;APOA2_33095;ALOX15_8036 44.4416885 37.15875 32.89985969546492 31.288897000000002 25.78745 24.889677883845128 80.922545 67.7504 60.421200060134645 20.8684;10.9914;13.8391;51.412;11.2357;54.7122;5.51457;91.9576;13.2391;30.5985;53.893;101.406;14.4142;21.7434;49.5529;43.719;28.2655;85.6642;80.183;105.624 17.1194;7.86591;9.31624;36.6131;4.94421;38.3856;1.34064;61.1322;9.02099;24.577;37.9512;84.6435;9.59235;12.6557;26.9979;33.4848;22.3101;53.6991;50.2978;83.8302 26.5474;18.2059;27.6952;86.0232;24.5771;94.9303;39.6721;110.707;25.4349;40.5656;92.6554;115.953;30.0753;160.485;71.5977;63.9031;38.3337;224.488;197.161;129.44 20 84386;29692;360918;338475;24587;299923;286918;290350;100911740;24516;24440;81660;116663;299691;84032;114851;24770;287562;29657;29339 SLPI_9890;PLA2G2A_32641;PF4_32963;NREP_9364;NEFH_33218;NDRG1_32364;MX2_9268;LOXL2_9150;LOC100911740_32571;JUN_8938;HBB_8782;GATM_32792;DUSP6_8506;CRY1_8386;COL3A1_8354;CDKN1A_8271;CCL2_8218;CCL12_8217;ARNTL_8086;APCS_8057 58.89226000000006 57.1428 28.713345912061108 36.00952000000006 39.009 14.590675601889524 139.97661000000008 106.006 108.06419450106537 56.5193;1.16694E-12;105.82;36.861;79.3182;99.6641;31.6605;65.4434;91.003;57.7663;91.4283;37.423;45.5478;37.2548;57.8774;54.5478;64.0097;25.5289;38.2177;101.954 39.3315;1.16694E-12;53.8521;28.0333;39.4261;42.5546;23.5989;43.7615;54.5666;38.6865;54.7263;28.03;33.3115;21.8798;39.4215;38.2987;41.1311;13.9582;27.1236;58.4986 100.108;1.16694E-12;109.875;53.5645;264.141;105.409;46.786;129.393;273.335;109.049;277.036;55.6613;71.7388;73.8251;106.603;94.4701;132.851;336.862;63.2034;395.621 0 Exp 2,11(0.28);Exp 3,2(0.05);Hill,3(0.08);Linear,13(0.33);Poly 2,10(0.25);Power,1(0.03) 1.903266021048099 78.82281517982483 1.5226441621780396 4.897102355957031 0.6302795782137789 1.7612069845199585 41.9529793687349 61.38096913126516 27.36470857650619 39.93370842349388 82.11083761212048 138.78831738787954 CONFLICT 0.5 0.5 0.0 GO:0098609 4 cell-cell adhesion 84 86 3 3 3 2 2 2 67 84 2394 0.58558 0.68522 1.0 2.33 29142;24367 vnn1;fgg VNN1_10157;FGG_8639 57.025400000000005 57.025400000000005 20.8684 51.13371977472399 56.01255384615386 51.11365359018348 34.2287 34.2287 17.1194 24.196204102709984 33.74942658959538 24.186708890962354 176.96269999999998 176.96269999999998 26.5474 212.7193572484178 172.74919893285903 212.63588071088662 20.8684;93.1824 17.1194;51.338 26.5474;327.378 1 1 1 29142 VNN1_10157 20.8684 20.8684 17.1194 17.1194 26.5474 26.5474 20.8684 17.1194 26.5474 1 24367 FGG_8639 93.1824 93.1824 51.338 51.338 327.378 327.378 93.1824 51.338 327.378 0 Exp 2,2(1) 2.245835157233 4.551142573356628 1.9088982343673706 2.642244338989258 0.5185540035348758 2.275571286678314 -13.84231999999998 127.89311999999998 0.6944720000000117 67.76292799999999 -117.85128799999998 471.77668800000004 CONFLICT 0.5 0.5 0.0 GO:0060255 5 regulation of macromolecule metabolic process 1000 1070 38 38 33 34 31 31 38 1039 1439 0.73395 0.35229 0.62302 2.9 360243;24825;78968;84386;24777;29692;360918;362282;316351;114519;366960;290350;24516;85430;24440;24367;361921;116663;24309;299691;498709;306575;114851;58919;24770;287562;282840;29657;25649;29339;81639 top2a;tf;srebf1;slpi;slc10a1;pla2g2a;pf4;pck1;npas2;nfil3;maff;loxl2;jun;herpud1;hbb;fgg;ect2;dusp6;dbp;cry1;cks2;ckap2;cdkn1a;ccnd1;ccl2;ccl12;atf5;arntl;apoa2;apcs;alox15 TOP2A_10059;TF_10003;SREBF1_32750;SLPI_9890;SLC10A1_9832;PLA2G2A_32641;PF4_32963;PCK1_9439;NPAS2_9350;NFIL3_9304;MAFF_9172;LOXL2_9150;JUN_8938;HERPUD1_8795;HBB_8782;FGG_8639;ECT2_8523;DUSP6_8506;DBP_8439;CRY1_8386;CKS2_8325;CKAP2_8324;CDKN1A_8271;CCND1_8224;CCL2_8218;CCL12_8217;ATF5_8097;ARNTL_8086;APOA2_33095;APCS_8057;ALOX15_8036 49.48960290322584 51.412 1.16694E-12 32.19839295074158 54.41438013388546 29.409921089304127 32.696391290322616 36.6131 1.16694E-12 21.245909053653506 36.606599863682696 20.491955896326626 108.84326129032263 92.6554 1.16694E-12 99.44507214416966 126.38618002760528 103.90597928432133 13.8391;51.412;11.2357;56.5193;7.96762;1.16694E-12;105.82;5.51457;58.2312;33.1149;58.0695;65.4434;57.7663;53.893;91.4283;93.1824;14.4142;45.5478;50.6952;37.2548;14.4197;12.1218;54.5478;28.2655;64.0097;25.5289;97.9563;38.2177;80.183;101.954;105.624 9.31624;36.6131;4.94421;39.3315;6.07525;1.16694E-12;53.8521;1.34064;35.795;25.603;40.1293;43.7615;38.6865;37.9512;54.7263;51.338;9.59235;33.3115;40.5862;21.8798;9.6236;8.47044;38.2987;22.3101;41.1311;13.9582;75.2121;27.1236;50.2978;58.4986;83.8302 27.6952;86.0232;24.5771;100.108;11.4863;1.16694E-12;109.875;39.6721;99.4319;46.6318;104.733;129.393;109.049;92.6554;277.036;327.378;30.0753;71.7388;59.5346;73.8251;29.0958;21.3803;94.4701;38.3337;132.851;336.862;114.804;63.2034;197.161;395.621;129.44 12 19 12 360243;24825;78968;362282;366960;85430;361921;498709;306575;58919;25649;81639 TOP2A_10059;TF_10003;SREBF1_32750;PCK1_9439;MAFF_9172;HERPUD1_8795;ECT2_8523;CKS2_8325;CKAP2_8324;CCND1_8224;APOA2_33095;ALOX15_8036 37.41600583333334 21.3426 32.21478279922616 26.201598333333333 15.966849999999999 24.452941955224507 68.40350833333333 39.0029 54.81814726651713 13.8391;51.412;11.2357;5.51457;58.0695;53.893;14.4142;14.4197;12.1218;28.2655;80.183;105.624 9.31624;36.6131;4.94421;1.34064;40.1293;37.9512;9.59235;9.6236;8.47044;22.3101;50.2978;83.8302 27.6952;86.0232;24.5771;39.6721;104.733;92.6554;30.0753;29.0958;21.3803;38.3337;197.161;129.44 19 84386;24777;29692;360918;316351;114519;290350;24516;24440;24367;116663;24309;299691;114851;24770;287562;282840;29657;29339 SLPI_9890;SLC10A1_9832;PLA2G2A_32641;PF4_32963;NPAS2_9350;NFIL3_9304;LOXL2_9150;JUN_8938;HBB_8782;FGG_8639;DUSP6_8506;DBP_8439;CRY1_8386;CDKN1A_8271;CCL2_8218;CCL12_8217;ATF5_8097;ARNTL_8086;APCS_8057 57.115032631579005 56.5193 30.579880252585138 36.79836578947375 38.6865 18.46673246809902 134.3841578947369 100.108 113.43266608365951 56.5193;7.96762;1.16694E-12;105.82;58.2312;33.1149;65.4434;57.7663;91.4283;93.1824;45.5478;50.6952;37.2548;54.5478;64.0097;25.5289;97.9563;38.2177;101.954 39.3315;6.07525;1.16694E-12;53.8521;35.795;25.603;43.7615;38.6865;54.7263;51.338;33.3115;40.5862;21.8798;38.2987;41.1311;13.9582;75.2121;27.1236;58.4986 100.108;11.4863;1.16694E-12;109.875;99.4319;46.6318;129.393;109.049;277.036;327.378;71.7388;59.5346;73.8251;94.4701;132.851;336.862;114.804;63.2034;395.621 0 Exp 2,4(0.13);Exp 3,1(0.04);Hill,3(0.1);Linear,12(0.39);Poly 2,9(0.3);Power,2(0.07) 2.076994728585687 69.15003156661987 1.5230457782745361 5.737884044647217 1.0448937724993734 1.8622472286224365 38.15491880546419 60.824287000987496 25.21727058198956 40.175511998655686 73.83597134396774 143.85055123667755 DOWN 0.3870967741935484 0.6129032258064516 0.0 GO:0042246 4 tissue regeneration 26 26 3 3 3 3 3 3 66 23 2455 0.9953 0.031687 0.031687 11.54 81660;170568;114851 gatm;dmbt1;cdkn1a GATM_32792;DMBT1_32993;CDKN1A_8271 37.90473333333333 37.423 21.7434 16.407504840570166 40.18983620210994 15.170906653189347 26.32813333333333 28.03 12.6557 12.905933707536752 28.36880684235254 11.652540778963907 103.5388 94.4701 55.6613 52.99700944572253 92.96092263699654 48.77662102263056 0.5 29.5832 1.5 45.9854 37.423;21.7434;54.5478 28.03;12.6557;38.2987 55.6613;160.485;94.4701 1 2 1 170568 DMBT1_32993 21.7434 21.7434 12.6557 12.6557 160.485 160.485 21.7434 12.6557 160.485 2 81660;114851 GATM_32792;CDKN1A_8271 45.9854 45.9854 12.109062206463422 33.16435 33.16435 7.261067403970299 75.06569999999999 75.06569999999999 27.44196564971254 37.423;54.5478 28.03;38.2987 55.6613;94.4701 0 Exp 2,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 1.7981691343662172 5.447718381881714 1.5998332500457764 2.1833407878875732 0.31984848565016805 1.6645443439483643 19.33789375392412 56.471572912742545 11.723694504961305 40.93257216170535 43.56703816732326 163.51056183267673 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:2000849 8 regulation of glucocorticoid secretion 1 1 1 1 1 1 1 1 68 0 2478 1.0 0.027091 0.027091 100.0 299691 cry1 CRY1_8386 37.2548 37.2548 37.2548 37.2548 21.8798 21.8798 21.8798 21.8798 73.8251 73.8251 73.8251 73.8251 0.0 37.2548 0.0 37.2548 37.2548 21.8798 73.8251 0 1 0 1 299691 CRY1_8386 37.2548 37.2548 21.8798 21.8798 73.8251 73.8251 37.2548 21.8798 73.8251 0 Exp 2,1(1) 1.8622472286224365 1.8622472286224365 1.8622472286224365 1.8622472286224365 0.0 1.8622472286224365 37.2548 37.2548 21.8798 21.8798 73.8251 73.8251 DOWN 0.0 1.0 0.0 GO:2000850 8 negative regulation of glucocorticoid secretion 1 1 1 1 1 1 1 1 68 0 2478 1.0 0.027091 0.027091 100.0 299691 cry1 CRY1_8386 37.2548 37.2548 37.2548 37.2548 21.8798 21.8798 21.8798 21.8798 73.8251 73.8251 73.8251 73.8251 0.0 37.2548 0.0 37.2548 37.2548 21.8798 73.8251 0 1 0 1 299691 CRY1_8386 37.2548 37.2548 21.8798 21.8798 73.8251 73.8251 37.2548 21.8798 73.8251 0 Exp 2,1(1) 1.8622472286224365 1.8622472286224365 1.8622472286224365 1.8622472286224365 0.0 1.8622472286224365 37.2548 37.2548 21.8798 21.8798 73.8251 73.8251 DOWN 0.0 1.0 0.0 GO:1903202 7 negative regulation of oxidative stress-induced cell death 25 26 2 2 2 2 2 2 67 24 2454 0.96831 0.15528 0.15528 7.69 29142;287877 vnn1;pycr1 VNN1_10157;PYCR1_9631 37.7903 37.7903 20.8684 23.931180481121288 46.256735811540956 20.720529156324986 27.752499999999998 27.752499999999998 17.1194 15.037474230069359 33.072497082342764 13.020018944215446 60.73885 60.73885 26.5474 48.354012307201565 77.845659325697 41.86674880610498 0.5 37.7903 20.8684;54.7122 17.1194;38.3856 26.5474;94.9303 2 0 2 29142;287877 VNN1_10157;PYCR1_9631 37.7903 37.7903 23.931180481121288 27.752499999999998 27.752499999999998 15.037474230069359 60.73885 60.73885 48.354012307201565 20.8684;54.7122 17.1194;38.3856 26.5474;94.9303 0 0 Exp 2,1(0.5);Linear,1(0.5) 2.0943842852445553 4.30236542224884 1.6601210832595825 2.642244338989258 0.6944660140874631 2.15118271112442 4.623376 70.957224 6.911624000000003 48.59337599999999 -6.276392000000001 127.754092 UP 1.0 0.0 0.0 GO:0006952 4 defense response 257 279 13 13 13 12 12 12 57 267 2211 0.96658 0.068048 0.11351 4.3 29142;24825;84386;29692;360918;314654;286918;170568;24770;287562;25649;29339 vnn1;tf;slpi;pla2g2a;pf4;myo1f;mx2;dmbt1;ccl2;ccl12;apoa2;apcs VNN1_10157;TF_10003;SLPI_9890;PLA2G2A_32641;PF4_32963;MYO1F_32715;MX2_9268;DMBT1_32993;CCL2_8218;CCL12_8217;APOA2_33095;APCS_8057 54.304733333333424 53.96565 1.16694E-12 35.145411858922955 54.268759649468045 32.223841313842414 34.01571666666677 37.972300000000004 1.16694E-12 20.200258936811558 34.28712889770101 18.98051938362363 141.9188833333334 110.291 1.16694E-12 118.78991577648804 174.19223881279237 130.02087508452166 20.8684;51.412;56.5193;1.16694E-12;105.82;91.9576;31.6605;21.7434;64.0097;25.5289;80.183;101.954 17.1194;36.6131;39.3315;1.16694E-12;53.8521;61.1322;23.5989;12.6557;41.1311;13.9582;50.2978;58.4986 26.5474;86.0232;100.108;1.16694E-12;109.875;110.707;46.786;160.485;132.851;336.862;197.161;395.621 5 7 5 29142;24825;314654;170568;25649 VNN1_10157;TF_10003;MYO1F_32715;DMBT1_32993;APOA2_33095 53.23288 51.412 32.666019911400284 35.56364 36.6131 20.83813692423102 116.18472000000001 110.707 66.13290514677239 20.8684;51.412;91.9576;21.7434;80.183 17.1194;36.6131;61.1322;12.6557;50.2978 26.5474;86.0232;110.707;160.485;197.161 7 84386;29692;360918;286918;24770;287562;29339 SLPI_9890;PLA2G2A_32641;PF4_32963;MX2_9268;CCL2_8218;CCL12_8217;APCS_8057 55.070342857143025 56.5193 39.38924735088882 32.91005714285731 39.3315 21.33504767691363 160.3004285714287 109.875 148.35252844138626 56.5193;1.16694E-12;105.82;31.6605;64.0097;25.5289;101.954 39.3315;1.16694E-12;53.8521;23.5989;41.1311;13.9582;58.4986 100.108;1.16694E-12;109.875;46.786;132.851;336.862;395.621 0 Exp 2,3(0.25);Exp 3,1(0.09);Hill,1(0.09);Linear,4(0.34);Poly 2,3(0.25) 1.8475359902184758 22.5875883102417 1.5314651727676392 2.6565301418304443 0.40042450453515743 1.7321658730506897 34.419344595754595 74.19012207091227 22.586344230495833 45.44508910283769 74.70716127977647 209.1306053868904 CONFLICT 0.4166666666666667 0.5833333333333334 0.0 GO:0048589 3 developmental growth 91 95 5 5 5 5 5 5 64 90 2388 0.95848 0.11225 0.18226 5.26 81660;170568;114851;282840;289054 gatm;dmbt1;cdkn1a;atf5;aspm GATM_32792;DMBT1_32993;CDKN1A_8271;ATF5_8097;ASPM_8092 44.3988 37.423 10.3235 34.25807573456221 51.15720996617149 32.17972838165527 32.33152 28.03 7.4611 26.918999499647086 37.52736713634358 25.51620315227107 88.45653999999999 94.4701 16.8623 55.044785334607326 91.92088966024416 45.622734820248375 3.5 76.25205 37.423;21.7434;54.5478;97.9563;10.3235 28.03;12.6557;38.2987;75.2121;7.4611 55.6613;160.485;94.4701;114.804;16.8623 2 3 2 170568;289054 DMBT1_32993;ASPM_8092 16.033450000000002 16.033450000000002 8.075088730472249 10.058399999999999 10.058399999999999 3.6731368855516426 88.67365000000001 88.67365000000001 101.55658510232116 21.7434;10.3235 12.6557;7.4611 160.485;16.8623 3 81660;114851;282840 GATM_32792;CDKN1A_8271;ATF5_8097 63.30903333333333 54.5478 31.203197101632625 47.18026666666666 38.2987 24.81328897875762 88.31179999999999 94.4701 30.048431489680183 37.423;54.5478;97.9563 28.03;38.2987;75.2121 55.6613;94.4701;114.804 0 Exp 2,1(0.2);Linear,1(0.2);Poly 2,3(0.6) 1.8460093617940838 9.378997921943665 1.5452834367752075 2.385996103286743 0.3823967827671459 1.6645443439483643 14.370272640639683 74.42732735936032 8.735976595142471 55.927063404857535 40.20765832849434 136.70542167150563 DOWN 0.4 0.6 0.0 GO:0051186 4 cofactor metabolic process 111 126 7 6 5 7 5 5 64 121 2357 0.87688 0.25378 0.3887 3.97 29142;287167;24450;24440;360504 vnn1;hba-a1;hmgcs2;hbb;hba-a2 VNN1_10157;LOC287167_9118;HMGCS2_8812;HBB_8782;HBA2_32600 69.90083999999999 91.4283 20.8684 40.77714814443258 55.6188530717568 38.65433886216328 52.621939999999995 54.7263 17.1194 31.394210591811365 41.34753628137151 27.985984323835847 118.06979999999999 115.953 26.5474 99.75754169976327 99.1360922446094 101.81199615194808 20.8684;105.203;30.5985;91.4283;101.406 17.1194;82.0435;24.577;54.7263;84.6435 26.5474;130.247;40.5656;277.036;115.953 4 1 4 29142;287167;24450;360504 VNN1_10157;LOC287167_9118;HMGCS2_8812;HBA2_32600 64.51897500000001 66.00225 44.988197806415464 52.09585 53.310249999999996 36.225453394770184 78.32825 78.2593 52.3400820782378 20.8684;105.203;30.5985;101.406 17.1194;82.0435;24.577;84.6435 26.5474;130.247;40.5656;115.953 1 24440 HBB_8782 91.4283 91.4283 54.7263 54.7263 277.036 277.036 91.4283 54.7263 277.036 0 Exp 2,2(0.4);Linear,1(0.2);Poly 2,2(0.4) 2.1557112218348276 11.220101356506348 1.6757243871688843 3.3687045574188232 0.7420175140809698 1.778118371963501 34.158093729624 105.643586270376 25.103701118572246 80.14017888142776 30.62845935249534 205.51114064750465 UP 0.8 0.2 0.0 GO:0048252 8 lauric acid metabolic process 3 4 1 1 1 1 1 1 68 3 2475 0.99581 0.1041 0.1041 25.0 24306 cyp4a2 CYP4A2_8425 59.5671 59.5671 59.5671 59.56710000000001 43.4174 43.4174 43.4174 43.4174 99.5908 99.5908 99.5908 99.5908 0.0 59.5671 0.0 59.5671 59.5671 43.4174 99.5908 1 0 1 24306 CYP4A2_8425 59.5671 59.5671 43.4174 43.4174 99.5908 99.5908 59.5671 43.4174 99.5908 0 0 Exp 2,1(1) 1.9150761365890503 1.9150761365890503 1.9150761365890503 1.9150761365890503 0.0 1.9150761365890503 59.5671 59.5671 43.4174 43.4174 99.5908 99.5908 UP 1.0 0.0 0.0 GO:0051222 6 positive regulation of protein transport 131 141 4 4 4 3 3 3 66 138 2340 0.46248 0.74649 1.0 2.13 24367;361921;24770 fgg;ect2;ccl2 FGG_8639;ECT2_8523;CCL2_8218 57.202099999999994 64.0097 14.4142 39.822919231643496 49.90646572796716 40.12338965943732 34.02048333333334 41.1311 9.59235 21.76224886163729 30.082851043210578 22.33538655405002 163.43476666666666 132.851 30.0753 150.99254598973857 137.04024592406793 144.73634959527146 93.1824;14.4142;64.0097 51.338;9.59235;41.1311 327.378;30.0753;132.851 1 2 1 361921 ECT2_8523 14.4142 14.4142 9.59235 9.59235 30.0753 30.0753 14.4142 9.59235 30.0753 2 24367;24770 FGG_8639;CCL2_8218 78.59604999999999 78.59604999999999 20.628213995520863 46.23455 46.23455 7.217368204892991 230.1145 230.1145 137.5513608238755 93.1824;64.0097 51.338;41.1311 327.378;132.851 0 Exp 2,2(0.67);Poly 2,1(0.34) 1.7434943286602513 5.248633861541748 1.559963583946228 1.9088982343673706 0.17642029469165377 1.7797720432281494 12.138224648920058 102.26597535107993 9.394180465995024 58.646786200671656 -7.429383996026303 334.2989173293596 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0019369 6 arachidonic acid metabolic process 29 34 5 5 5 4 4 4 65 30 2448 0.99809 0.012398 0.012398 11.76 24306;25086;499353;81639 cyp4a2;cyp2e1;cyp2c24;alox15 CYP4A2_8425;CYP2E1_8421;CYP2C24_32875;ALOX15_8036 56.327275 54.56 10.5651 39.0757059186715 60.87356147513995 40.875634371366054 40.4704725 35.20765 7.63639 32.39515156083842 45.31538998024367 33.673915838774505 79.41890000000001 85.59425 17.0471 47.820597373586466 85.42437656992334 49.268468755663285 0.5 30.059 2.5 82.59555 59.5671;49.5529;10.5651;105.624 43.4174;26.9979;7.63639;83.8302 99.5908;71.5977;17.0471;129.44 3 1 3 24306;25086;81639 CYP4A2_8425;CYP2E1_8421;ALOX15_8036 71.58133333333333 59.5671 29.903986619568514 51.415166666666664 43.4174 29.248090272073043 100.2095 99.5908 28.926112936065174 59.5671;49.5529;105.624 43.4174;26.9979;83.8302 99.5908;71.5977;129.44 1 499353 CYP2C24_32875 10.5651 10.5651 7.63639 7.63639 17.0471 17.0471 10.5651 7.63639 17.0471 0 Exp 2,1(0.25);Poly 2,3(0.75) 2.0108568301617162 8.100712299346924 1.6914535760879517 2.2906150817871094 0.27433195905809754 2.0593218207359314 18.03308319970192 94.62146680029808 8.723223970378353 72.21772102962164 32.554714573885235 126.28308542611475 UP 0.75 0.25 0.0 GO:0050896 2 response to stimulus 1203 1308 63 61 57 57 52 52 17 1256 1222 0.99999 3.0293E-5 4.3647E-5 3.98 29142;360847;360243;24825;78968;84386;24777;25044;83792;287877;29692;360918;362282;338475;316351;114519;24587;299923;314654;286918;58827;290350;100911740;293502;24516;79438;24450;85430;362376;24440;360504;316033;81660;81714;24367;361921;116663;170568;24306;25086;29680;299691;84032;114851;58919;24770;287562;25612;29657;25649;29339;81639 vnn1;ube2t;top2a;tf;srebf1;slpi;slc10a1;sds;scd2;pycr1;pla2g2a;pf4;pck1;nrep;npas2;nfil3;nefh;ndrg1;myo1f;mx2;mest;loxl2;mrln;kif22;jun;igfals;hmgcs2;herpud1;herc6;hbb;hba-a2;glb1;gatm;gas5;fgg;ect2;dusp6;dmbt1;cyp4a2;cyp2e1;cyp11a1;cry1;col3a1;cdkn1a;ccnd1;ccl2;ccl12;asns;arntl;apoa2;apcs;alox15 VNN1_10157;UBE2T_10125;TOP2A_10059;TF_10003;SREBF1_32750;SLPI_9890;SLC10A1_9832;SDS_9798;SCD_9786;PYCR1_9631;PLA2G2A_32641;PF4_32963;PCK1_9439;NREP_9364;NPAS2_9350;NFIL3_9304;NEFH_33218;NDRG1_32364;MYO1F_32715;MX2_9268;MEST_9219;LOXL2_9150;LOC100911740_32571;KIF22_8963;JUN_8938;IGFALS_8880;HMGCS2_8812;HERPUD1_8795;HERC6_8794;HBB_8782;HBA2_32600;GLB1_8712;GATM_32792;GAS5_8688;FGG_8639;ECT2_8523;DUSP6_8506;DMBT1_32993;CYP4A2_8425;CYP2E1_8421;CYP11A1_32785;CRY1_8386;COL3A1_8354;CDKN1A_8271;CCND1_8224;CCL2_8218;CCL12_8217;ASNS_8091;ARNTL_8086;APOA2_33095;APCS_8057;ALOX15_8036 53.73536711538463 54.2204 1.16694E-12 30.07917646850312 54.84960847689085 27.802342685904403 35.055884423076954 37.28215 1.16694E-12 19.09681238070168 35.49038127160988 17.107236476109687 117.06054615384618 98.90039999999999 1.16694E-12 93.68738598271328 124.55280075610081 95.7983498889636 20.8684;10.9914;13.8391;51.412;11.2357;56.5193;7.96762;64.7394;83.9984;54.7122;1.16694E-12;105.82;5.51457;36.861;58.2312;33.1149;79.3182;99.6641;91.9576;31.6605;96.9172;65.4434;91.003;13.2391;57.7663;70.3663;30.5985;53.893;53.833;91.4283;101.406;65.9159;37.423;39.7267;93.1824;14.4142;45.5478;21.7434;59.5671;49.5529;43.719;37.2548;57.8774;54.5478;28.2655;64.0097;25.5289;85.6642;38.2177;80.183;101.954;105.624 17.1194;7.86591;9.31624;36.6131;4.94421;39.3315;6.07525;43.4259;54.1928;38.3856;1.16694E-12;53.8521;1.34064;28.0333;35.795;25.603;39.4261;42.5546;61.1322;23.5989;56.7353;43.7615;54.5666;9.02099;38.6865;46.0459;24.577;37.9512;36.3389;54.7263;84.6435;47.8573;28.03;30.1129;51.338;9.59235;33.3115;12.6557;43.4174;26.9979;33.4848;21.8798;39.4215;38.2987;22.3101;41.1311;13.9582;53.6991;27.1236;50.2978;58.4986;83.8302 26.5474;18.2059;27.6952;86.0232;24.5771;100.108;11.4863;126.828;206.18;94.9303;1.16694E-12;109.875;39.6721;53.5645;99.4319;46.6318;264.141;105.409;110.707;46.786;331.492;129.393;273.335;25.4349;109.049;148.796;40.5656;92.6554;98.3689;277.036;115.953;114.587;55.6613;58.3946;327.378;30.0753;71.7388;160.485;99.5908;71.5977;63.9031;73.8251;106.603;94.4701;38.3337;132.851;336.862;224.488;63.2034;197.161;395.621;129.44 24 28 24 29142;360847;360243;24825;78968;83792;287877;362282;314654;293502;24450;85430;360504;316033;81714;361921;170568;24306;25086;29680;58919;25612;25649;81639 VNN1_10157;UBE2T_10125;TOP2A_10059;TF_10003;SREBF1_32750;SCD_9786;PYCR1_9631;PCK1_9439;MYO1F_32715;KIF22_8963;HMGCS2_8812;HERPUD1_8795;HBA2_32600;GLB1_8712;GAS5_8688;ECT2_8523;DMBT1_32993;CYP4A2_8425;CYP2E1_8421;CYP11A1_32785;CCND1_8224;ASNS_8091;APOA2_33095;ALOX15_8036 47.41841124999999 46.63595 31.36727586234049 33.38993083333333 31.79885 23.416888467595147 87.38347083333333 78.81045 61.16286136162437 20.8684;10.9914;13.8391;51.412;11.2357;83.9984;54.7122;5.51457;91.9576;13.2391;30.5985;53.893;101.406;65.9159;39.7267;14.4142;21.7434;59.5671;49.5529;43.719;28.2655;85.6642;80.183;105.624 17.1194;7.86591;9.31624;36.6131;4.94421;54.1928;38.3856;1.34064;61.1322;9.02099;24.577;37.9512;84.6435;47.8573;30.1129;9.59235;12.6557;43.4174;26.9979;33.4848;22.3101;53.6991;50.2978;83.8302 26.5474;18.2059;27.6952;86.0232;24.5771;206.18;94.9303;39.6721;110.707;25.4349;40.5656;92.6554;115.953;114.587;58.3946;30.0753;160.485;99.5908;71.5977;63.9031;38.3337;224.488;197.161;129.44 28 84386;24777;25044;29692;360918;338475;316351;114519;24587;299923;286918;58827;290350;100911740;24516;79438;362376;24440;81660;24367;116663;299691;84032;114851;24770;287562;29657;29339 SLPI_9890;SLC10A1_9832;SDS_9798;PLA2G2A_32641;PF4_32963;NREP_9364;NPAS2_9350;NFIL3_9304;NEFH_33218;NDRG1_32364;MX2_9268;MEST_9219;LOXL2_9150;LOC100911740_32571;JUN_8938;IGFALS_8880;HERC6_8794;HBB_8782;GATM_32792;FGG_8639;DUSP6_8506;CRY1_8386;COL3A1_8354;CDKN1A_8271;CCL2_8218;CCL12_8217;ARNTL_8086;APCS_8057 59.14990071428576 57.82185 28.371991009841512 36.483844642857186 39.009 14.736364052393979 142.49803928571436 106.006 109.26483306306172 56.5193;7.96762;64.7394;1.16694E-12;105.82;36.861;58.2312;33.1149;79.3182;99.6641;31.6605;96.9172;65.4434;91.003;57.7663;70.3663;53.833;91.4283;37.423;93.1824;45.5478;37.2548;57.8774;54.5478;64.0097;25.5289;38.2177;101.954 39.3315;6.07525;43.4259;1.16694E-12;53.8521;28.0333;35.795;25.603;39.4261;42.5546;23.5989;56.7353;43.7615;54.5666;38.6865;46.0459;36.3389;54.7263;28.03;51.338;33.3115;21.8798;39.4215;38.2987;41.1311;13.9582;27.1236;58.4986 100.108;11.4863;126.828;1.16694E-12;109.875;53.5645;99.4319;46.6318;264.141;105.409;46.786;331.492;129.393;273.335;109.049;148.796;98.3689;277.036;55.6613;327.378;71.7388;73.8251;106.603;94.4701;132.851;336.862;63.2034;395.621 0 Exp 2,17(0.33);Exp 3,2(0.04);Hill,3(0.06);Linear,17(0.33);Poly 2,11(0.22);Power,2(0.04) 1.9427256615024922 105.23767697811127 1.5059963464736938 4.897102355957031 0.7019097489287893 1.797882854938507 45.55975382159239 61.91098040917692 29.865311691399654 40.24645715475424 91.59602457351065 142.5250677341817 CONFLICT 0.46153846153846156 0.5384615384615384 0.0 GO:0031640 4 killing of cells of other organism 20 23 2 2 2 2 2 2 67 21 2457 0.97714 0.12717 0.12717 8.7 360918;287562 pf4;ccl12 PF4_32963;CCL12_8217 65.67445 65.67445 25.5289 56.77438127892721 39.32557463949573 42.83461105319179 33.90515 33.90515 13.9582 28.20924721797801 20.813295501252053 21.283052416705313 223.3685 223.3685 109.875 160.50404694119086 297.85810309990507 121.09561158248974 0.5 65.67445 105.82;25.5289 53.8521;13.9582 109.875;336.862 0 2 0 2 360918;287562 PF4_32963;CCL12_8217 65.67445 65.67445 56.77438127892721 33.90515 33.90515 28.20924721797801 223.3685 223.3685 160.50404694119086 105.82;25.5289 53.8521;13.9582 109.875;336.862 0 Exp 3,1(0.5);Poly 2,1(0.5) 1.6785852409216002 3.3713035583496094 1.5314651727676392 1.8398383855819702 0.21805278991729585 1.6856517791748047 -13.010828000000004 144.359728 -5.190871999999999 73.001172 0.9212399999999832 445.81576000000007 DOWN 0.0 1.0 0.0 GO:0010959 7 regulation of metal ion transport 108 117 4 4 4 3 3 3 66 114 2364 0.60805 0.62286 1.0 2.56 24825;100911740;24770 tf;mrln;ccl2 TF_10003;LOC100911740_32571;CCL2_8218 68.80823333333332 64.0097 51.412 20.22699339653162 62.243466222589014 17.279415073357374 44.1036 41.1311 36.6131 9.33856829230262 41.12979276114124 7.805372755290702 164.06973333333335 132.851 86.0232 97.48017535895866 133.04433055883047 81.43489898289573 51.412;91.003;64.0097 36.6131;54.5666;41.1311 86.0232;273.335;132.851 1 2 1 24825 TF_10003 51.412 51.412 36.6131 36.6131 86.0232 86.0232 51.412 36.6131 86.0232 2 100911740;24770 LOC100911740_32571;CCL2_8218 77.50635 77.50635 19.08714547660279 47.84885 47.84885 9.500333158631918 203.093 203.093 99.3371890482109 91.003;64.0097 54.5666;41.1311 273.335;132.851 0 Exp 2,1(0.34);Linear,2(0.67) 1.7841848451724145 5.380848169326782 1.559963583946228 2.0048909187316895 0.2233061830508563 1.8159936666488647 45.919235571860085 91.69723109480658 33.536015161883014 54.671184838116986 53.7605305844058 274.3789360822609 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0031100 5 animal organ regeneration 72 80 6 5 4 6 4 4 65 76 2402 0.93672 0.16928 0.16928 5.0 114851;58919;24770;25649 cdkn1a;ccnd1;ccl2;apoa2 CDKN1A_8271;CCND1_8224;CCL2_8218;APOA2_33095 56.75149999999999 59.27875 28.2655 21.741091272672314 57.94002417490176 22.482723248824723 38.009425 39.7149 22.3101 11.651916872736724 38.850994871990544 12.027478737624785 115.70395 113.66055 38.3337 66.74904316240543 119.63675974283645 70.97415141008499 3.0 80.183 54.5478;28.2655;64.0097;80.183 38.2987;22.3101;41.1311;50.2978 94.4701;38.3337;132.851;197.161 2 2 2 58919;25649 CCND1_8224;APOA2_33095 54.224250000000005 54.224250000000005 36.71121631225258 36.30395 36.30395 19.790292459814737 117.74735 117.74735 112.30786086755015 28.2655;80.183 22.3101;50.2978 38.3337;197.161 2 114851;24770 CDKN1A_8271;CCL2_8218 59.27875 59.27875 6.690573652908962 39.7149 39.7149 2.0028092470327894 113.66055 113.66055 27.139394658042768 54.5478;64.0097 38.2987;41.1311 94.4701;132.851 0 Exp 2,1(0.25);Linear,3(0.75) 1.845776156314516 7.463345170021057 1.559963583946228 2.2675669193267822 0.31967712548007393 1.8179073333740234 35.44523055278117 78.05776944721883 26.590546464718013 49.428303535281984 50.28988770084264 181.11801229915733 CONFLICT 0.5 0.5 0.0 GO:0051172 6 negative regulation of nitrogen compound metabolic process 471 499 16 16 14 15 13 13 56 486 1992 0.50965 0.61241 1.0 2.61 78968;84386;114519;290350;24516;85430;116663;299691;114851;58919;282840;29657;29339 srebf1;slpi;nfil3;loxl2;jun;herpud1;dusp6;cry1;cdkn1a;ccnd1;atf5;arntl;apcs SREBF1_32750;SLPI_9890;NFIL3_9304;LOXL2_9150;JUN_8938;HERPUD1_8795;DUSP6_8506;CRY1_8386;CDKN1A_8271;CCND1_8224;ATF5_8097;ARNTL_8086;APCS_8057 52.43973076923077 53.893 11.2357 25.625588087963447 56.545165337927514 25.01528151223829 35.91633153846154 37.9512 4.94421 17.504058252505253 38.64686872182923 16.96193659324605 104.18541538461538 92.6554 24.5771 92.91164851050563 114.48974544580132 98.50562985323745 11.2357;56.5193;33.1149;65.4434;57.7663;53.893;45.5478;37.2548;54.5478;28.2655;97.9563;38.2177;101.954 4.94421;39.3315;25.603;43.7615;38.6865;37.9512;33.3115;21.8798;38.2987;22.3101;75.2121;27.1236;58.4986 24.5771;100.108;46.6318;129.393;109.049;92.6554;71.7388;73.8251;94.4701;38.3337;114.804;63.2034;395.621 3 10 3 78968;85430;58919 SREBF1_32750;HERPUD1_8795;CCND1_8224 31.1314 28.2655 21.4725719914965 21.73517 22.3101 16.51100407587921 51.8554 38.3337 35.99709725644556 11.2357;53.893;28.2655 4.94421;37.9512;22.3101 24.5771;92.6554;38.3337 10 84386;114519;290350;24516;116663;299691;114851;282840;29657;29339 SLPI_9890;NFIL3_9304;LOXL2_9150;JUN_8938;DUSP6_8506;CRY1_8386;CDKN1A_8271;ATF5_8097;ARNTL_8086;APCS_8057 58.832229999999996 55.533550000000005 24.00724690986501 40.170680000000004 38.492599999999996 16.149190954747198 119.88442 97.28905 100.17730511220593 56.5193;33.1149;65.4434;57.7663;45.5478;37.2548;54.5478;97.9563;38.2177;101.954 39.3315;25.603;43.7615;38.6865;33.3115;21.8798;38.2987;75.2121;27.1236;58.4986 100.108;46.6318;129.393;109.049;71.7388;73.8251;94.4701;114.804;63.2034;395.621 0 Exp 2,2(0.16);Hill,1(0.08);Linear,8(0.62);Poly 2,1(0.08);Power,1(0.08) 2.043489215355453 28.332376956939697 1.5230457782745361 4.897102355957031 0.9479200627354937 1.7373461723327637 38.50950240326615 66.36995913519539 26.401017082007073 45.431645994915996 53.67806791743612 154.6927628517946 DOWN 0.23076923076923078 0.7692307692307693 0.0 GO:0051051 5 negative regulation of transport 140 146 7 7 6 6 5 5 64 141 2337 0.79936 0.36181 0.59398 3.42 78968;286918;100911740;299691;25649 srebf1;mx2;mrln;cry1;apoa2 SREBF1_32750;MX2_9268;LOC100911740_32571;CRY1_8386;APOA2_33095 50.267399999999995 37.2548 11.2357 33.88713001266117 48.94404435009361 27.239011224499833 31.057461999999997 23.5989 4.94421 20.88439448946797 31.14324000501471 16.61486113307758 123.13683999999998 73.8251 24.5771 107.25458539206146 107.91848204065258 83.37993304901967 11.2357;31.6605;91.003;37.2548;80.183 4.94421;23.5989;54.5666;21.8798;50.2978 24.5771;46.786;273.335;73.8251;197.161 2 3 2 78968;25649 SREBF1_32750;APOA2_33095 45.70935 45.70935 48.75310337450326 27.621005 27.621005 32.06983104015439 110.86905 110.86905 122.03524601362099 11.2357;80.183 4.94421;50.2978 24.5771;197.161 3 286918;100911740;299691 MX2_9268;LOC100911740_32571;CRY1_8386 53.306099999999994 37.2548 32.766083841832554 33.34843333333333 23.5989 18.39556396861302 131.31536666666668 73.8251 123.73342483461502 31.6605;91.003;37.2548 23.5989;54.5666;21.8798 46.786;273.335;73.8251 0 Exp 2,2(0.4);Hill,1(0.2);Linear,2(0.4) 2.191983698958759 11.163460850715637 1.8159936666488647 2.857419490814209 0.487116857442332 1.9712703227996826 20.564020901892015 79.97077909810798 12.751483107030023 49.363440892969976 29.12405081659952 217.14962918340046 DOWN 0.4 0.6 0.0 GO:0072330 7 monocarboxylic acid biosynthetic process 51 55 6 6 6 5 5 5 64 50 2428 0.99677 0.015355 0.015355 9.09 25044;83792;81660;25612;81639 sds;scd2;gatm;asns;alox15 SDS_9798;SCD_9786;GATM_32792;ASNS_8091;ALOX15_8036 75.48979999999999 83.9984 37.423 25.732455486020008 71.5217861741391 29.059793987351917 52.6356 53.6991 28.03 20.41392354925922 50.694026438589184 22.520292463600967 148.51946000000004 129.44 55.6613 68.10495586268293 134.12825063384574 71.6826775685463 1.5 74.3689 64.7394;83.9984;37.423;85.6642;105.624 43.4259;54.1928;28.03;53.6991;83.8302 126.828;206.18;55.6613;224.488;129.44 3 2 3 83792;25612;81639 SCD_9786;ASNS_8091;ALOX15_8036 91.7622 85.6642 12.033530107162896 63.90736666666667 54.1928 17.255445544619597 186.70266666666666 206.18 50.42871663381237 83.9984;85.6642;105.624 54.1928;53.6991;83.8302 206.18;224.488;129.44 2 25044;81660 SDS_9798;GATM_32792 51.0812 51.0812 19.315611677604206 35.72795 35.72795 10.886545292469966 91.24465000000001 91.24465000000001 50.322456164668644 64.7394;37.423 43.4259;28.03 126.828;55.6613 0 Exp 2,3(0.6);Linear,1(0.2);Poly 2,1(0.2) 1.84161643141072 9.262644529342651 1.5959433317184448 2.1833407878875732 0.2269127451419137 1.8739502429962158 52.934308279666595 98.04529172033341 34.74200706849807 70.52919293150194 88.82283412187587 208.21608587812415 UP 0.6 0.4 0.0 GO:0006807 3 nitrogen compound metabolic process 1028 1128 42 39 36 37 31 31 38 1097 1381 0.59303 0.50393 1.0 2.75 29142;360847;360243;24825;78968;25044;287877;29692;362282;114519;290350;293502;24516;24450;85430;362376;24440;81660;24367;171142;116663;25086;299691;84032;297594;58919;24770;287562;25612;29657;25649 vnn1;ube2t;top2a;tf;srebf1;sds;pycr1;pla2g2a;pck1;nfil3;loxl2;kif22;jun;hmgcs2;herpud1;herc6;hbb;gatm;fgg;ehhadh;dusp6;cyp2e1;cry1;col3a1;cdca3;ccnd1;ccl2;ccl12;asns;arntl;apoa2 VNN1_10157;UBE2T_10125;TOP2A_10059;TF_10003;SREBF1_32750;SDS_9798;PYCR1_9631;PLA2G2A_32641;PCK1_9439;NFIL3_9304;LOXL2_9150;KIF22_8963;JUN_8938;HMGCS2_8812;HERPUD1_8795;HERC6_8794;HBB_8782;GATM_32792;FGG_8639;EHHADH_8534;DUSP6_8506;CYP2E1_8421;CRY1_8386;COL3A1_8354;CDCA3_8260;CCND1_8224;CCL2_8218;CCL12_8217;ASNS_8091;ARNTL_8086;APOA2_33095 42.27907967741939 38.2177 1.16694E-12 26.148245917076995 44.43082305731135 22.912659286611486 27.928933645161333 27.1236 1.16694E-12 16.309533659694814 29.6964843064776 14.381651701423777 97.30132161290327 71.7388 1.16694E-12 88.77082481211833 107.09013798804332 90.05208749425948 20.8684;10.9914;13.8391;51.412;11.2357;64.7394;54.7122;1.16694E-12;5.51457;33.1149;65.4434;13.2391;57.7663;30.5985;53.893;53.833;91.4283;37.423;93.1824;32.6956;45.5478;49.5529;37.2548;57.8774;2.6193;28.2655;64.0097;25.5289;85.6642;38.2177;80.183 17.1194;7.86591;9.31624;36.6131;4.94421;43.4259;38.3856;1.16694E-12;1.34064;25.603;43.7615;9.02099;38.6865;24.577;37.9512;36.3389;54.7263;28.03;51.338;25.6436;33.3115;26.9979;21.8798;39.4215;0.978353;22.3101;41.1311;13.9582;53.6991;27.1236;50.2978 26.5474;18.2059;27.6952;86.0232;24.5771;126.828;94.9303;1.16694E-12;39.6721;46.6318;129.393;25.4349;109.049;40.5656;92.6554;98.3689;277.036;55.6613;327.378;45.0542;71.7388;71.5977;73.8251;106.603;7.96997;38.3337;132.851;336.862;224.488;63.2034;197.161 16 15 16 29142;360847;360243;24825;78968;287877;362282;293502;24450;85430;171142;25086;297594;58919;25612;25649 VNN1_10157;UBE2T_10125;TOP2A_10059;TF_10003;SREBF1_32750;PYCR1_9631;PCK1_9439;KIF22_8963;HMGCS2_8812;HERPUD1_8795;EHHADH_8534;CYP2E1_8421;CDCA3_8260;CCND1_8224;ASNS_8091;APOA2_33095 34.080279374999996 29.432000000000002 25.912161965257546 22.9413214375 23.443550000000002 16.902521155521843 66.306979375 40.11885 62.65301753750525 20.8684;10.9914;13.8391;51.412;11.2357;54.7122;5.51457;13.2391;30.5985;53.893;32.6956;49.5529;2.6193;28.2655;85.6642;80.183 17.1194;7.86591;9.31624;36.6131;4.94421;38.3856;1.34064;9.02099;24.577;37.9512;25.6436;26.9979;0.978353;22.3101;53.6991;50.2978 26.5474;18.2059;27.6952;86.0232;24.5771;94.9303;39.6721;25.4349;40.5656;92.6554;45.0542;71.5977;7.96997;38.3337;224.488;197.161 15 25044;29692;114519;290350;24516;362376;24440;81660;24367;116663;299691;84032;24770;287562;29657 SDS_9798;PLA2G2A_32641;NFIL3_9304;LOXL2_9150;JUN_8938;HERC6_8794;HBB_8782;GATM_32792;FGG_8639;DUSP6_8506;CRY1_8386;COL3A1_8354;CCL2_8218;CCL12_8217;ARNTL_8086 51.024466666666754 53.833 24.2274471626017 33.249053333333414 36.3389 14.32286586874603 130.36195333333342 106.603 102.03686395399215 64.7394;1.16694E-12;33.1149;65.4434;57.7663;53.833;91.4283;37.423;93.1824;45.5478;37.2548;57.8774;64.0097;25.5289;38.2177 43.4259;1.16694E-12;25.603;43.7615;38.6865;36.3389;54.7263;28.03;51.338;33.3115;21.8798;39.4215;41.1311;13.9582;27.1236 126.828;1.16694E-12;46.6318;129.393;109.049;98.3689;277.036;55.6613;327.378;71.7388;73.8251;106.603;132.851;336.862;63.2034 0 Exp 2,11(0.36);Exp 4,1(0.04);Hill,3(0.1);Linear,10(0.33);Poly 2,5(0.17);Power,1(0.04) 2.0098279301754913 64.8285573720932 1.5089621543884277 4.897102355957031 0.6941526310515668 1.9088982343673706 33.07420701082169 51.483952344017105 22.18754735618526 33.670319934137396 66.05164844187225 128.55099478393427 CONFLICT 0.5161290322580645 0.4838709677419355 0.0 GO:0046337 7 phosphatidylethanolamine metabolic process 8 8 2 2 2 2 2 2 67 6 2472 0.99903 0.018227 0.018227 25.0 29692;81639 pla2g2a;alox15 PLA2G2A_32641;ALOX15_8036 52.81200000000058 52.81200000000058 1.16694E-12 74.68744665604706 75.31302691689041 67.56938850818966 41.915100000000585 41.915100000000585 1.16694E-12 59.276902888223695 59.77340480428988 53.627540639620044 64.72000000000058 64.72000000000058 1.16694E-12 91.52790175678588 92.29453726541587 82.80487056445591 0.0 1.16694E-12 0.0 1.16694E-12 1.16694E-12;105.624 1.16694E-12;83.8302 1.16694E-12;129.44 1 1 1 81639 ALOX15_8036 105.624 105.624 83.8302 83.8302 129.44 129.44 105.624 83.8302 129.44 1 29692 PLA2G2A_32641 1.16694E-12 1.16694E-12 1.16694E-12 1.16694E-12 1.16694E-12 1.16694E-12 1.16694E-12 1.16694E-12 1.16694E-12 0 Hill,1(0.5);Poly 2,1(0.5) 1.8339075488943015 3.6798125505447388 1.6914535760879517 1.988358974456787 0.20994382055749686 1.8399062752723694 -50.69951999999827 156.32351999999943 -40.23849599999827 124.06869599999945 -62.131199999998245 191.5711999999994 CONFLICT 0.5 0.5 0.0 GO:0090068 7 positive regulation of cell cycle process 80 86 3 3 3 3 3 3 66 83 2395 0.79769 0.41442 0.50488 3.49 361921;114851;58919 ect2;cdkn1a;ccnd1 ECT2_8523;CDKN1A_8271;CCND1_8224 32.409166666666664 28.2655 14.4142 20.385140233104444 37.56789289934414 20.19352001306929 23.400383333333334 22.3101 9.59235 14.384198653064871 27.089857938099623 13.876771322498058 54.293033333333334 38.3337 30.0753 35.03851890553215 62.572284682096594 36.37549058138675 14.4142;54.5478;28.2655 9.59235;38.2987;22.3101 30.0753;94.4701;38.3337 2 1 2 361921;58919 ECT2_8523;CCND1_8224 21.33985 21.33985 9.794348158249228 15.951224999999999 15.951224999999999 8.992807266435213 34.204499999999996 34.204499999999996 5.839570641751015 14.4142;28.2655 9.59235;22.3101 30.0753;38.3337 1 114851 CDKN1A_8271 54.5478 54.5478 38.2987 38.2987 94.4701 94.4701 54.5478 38.2987 94.4701 0 Linear,2(0.67);Poly 2,1(0.34) 1.8868612005147878 5.711883306503296 1.6645443439483643 2.2675669193267822 0.32011911591505354 1.7797720432281494 9.341208912606472 55.47712442072685 7.123130243062182 39.67763642360448 14.643216621988373 93.9428500446783 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0071456 5 cellular response to hypoxia 57 60 3 3 3 2 2 2 67 58 2420 0.77941 0.48831 0.67703 3.33 362282;299923 pck1;ndrg1 PCK1_9439;NDRG1_32364 52.589335000000005 52.589335000000005 5.51457 66.57377110852629 86.80004931434809 45.730963818998696 21.94762 21.94762 1.34064 29.142670595551124 36.92336136931931 20.018730986736315 72.54055 72.54055 39.6721 46.483007764181984 96.42708778527485 31.93018377758376 5.51457;99.6641 1.34064;42.5546 39.6721;105.409 1 1 1 362282 PCK1_9439 5.51457 5.51457 1.34064 1.34064 39.6721 39.6721 5.51457 1.34064 39.6721 1 299923 NDRG1_32364 99.6641 99.6641 42.5546 42.5546 105.409 105.409 99.6641 42.5546 105.409 0 Exp 3,1(0.5);Hill,1(0.5) 1.8895637160169436 3.867545962333679 1.5226441621780396 2.3449018001556396 0.5814239516963943 1.9337729811668396 -39.67720439999999 144.85587439999998 -18.442060799999993 62.337300799999994 8.118387999999996 136.962712 CONFLICT 0.5 0.5 0.0 GO:0006635 7 fatty acid beta-oxidation 29 33 2 2 2 2 2 2 67 31 2447 0.94182 0.22443 0.22443 6.06 171142;29740 ehhadh;eci1 EHHADH_8534;ECI1_8520 67.9633 67.9633 32.6956 49.8760596537056 71.45712971979788 49.63071261183054 37.82055 37.82055 25.6436 17.220807838339077 39.0268716429337 17.136096369727255 76.1491 76.1491 45.0542 43.97482930063513 79.2295471443883 43.75851120412185 0.5 67.9633 32.6956;103.231 25.6436;49.9975 45.0542;107.244 2 0 2 171142;29740 EHHADH_8534;ECI1_8520 67.9633 67.9633 49.8760596537056 37.82055 37.82055 17.220807838339077 76.1491 76.1491 43.97482930063513 32.6956;103.231 25.6436;49.9975 45.0542;107.244 0 0 Exp 2,1(0.5);Exp 3,1(0.5) 1.7140085171049648 3.4336525201797485 1.618504285812378 1.8151482343673706 0.1390482695025339 1.7168262600898743 -1.1613919999999922 137.08799199999999 13.953727999999991 61.687372 15.203096000000016 137.095104 UP 1.0 0.0 0.0 GO:0033993 5 response to lipid 414 443 25 24 21 21 18 18 51 425 2053 0.97753 0.043232 0.074243 4.06 78968;84386;24777;83792;360918;362282;24587;58827;24516;79438;24450;360504;316033;29680;114851;58919;24770;25649 srebf1;slpi;slc10a1;scd2;pf4;pck1;nefh;mest;jun;igfals;hmgcs2;hba-a2;glb1;cyp11a1;cdkn1a;ccnd1;ccl2;apoa2 SREBF1_32750;SLPI_9890;SLC10A1_9832;SCD_9786;PF4_32963;PCK1_9439;NEFH_33218;MEST_9219;JUN_8938;IGFALS_8880;HMGCS2_8812;HBA2_32600;GLB1_8712;CYP11A1_32785;CDKN1A_8271;CCND1_8224;CCL2_8218;APOA2_33095 58.003832777777774 60.888 5.51457 31.48996694052956 59.462970784250814 26.270596347660586 37.95725555555556 39.3788 1.34064 20.679516334813105 38.41944082358814 15.55704143139228 119.06672222222223 109.462 11.4863 85.62571332834382 131.68577987735316 86.71322670694315 11.2357;56.5193;7.96762;83.9984;105.82;5.51457;79.3182;96.9172;57.7663;70.3663;30.5985;101.406;65.9159;43.719;54.5478;28.2655;64.0097;80.183 4.94421;39.3315;6.07525;54.1928;53.8521;1.34064;39.4261;56.7353;38.6865;46.0459;24.577;84.6435;47.8573;33.4848;38.2987;22.3101;41.1311;50.2978 24.5771;100.108;11.4863;206.18;109.875;39.6721;264.141;331.492;109.049;148.796;40.5656;115.953;114.587;63.9031;94.4701;38.3337;132.851;197.161 9 9 9 78968;83792;362282;24450;360504;316033;29680;58919;25649 SREBF1_32750;SCD_9786;PCK1_9439;HMGCS2_8812;HBA2_32600;GLB1_8712;CYP11A1_32785;CCND1_8224;APOA2_33095 50.09295222222222 43.719 34.155163829215404 35.960905555555556 33.4848 26.296707985562147 93.43695555555557 63.9031 69.60630820825635 11.2357;83.9984;5.51457;30.5985;101.406;65.9159;43.719;28.2655;80.183 4.94421;54.1928;1.34064;24.577;84.6435;47.8573;33.4848;22.3101;50.2978 24.5771;206.18;39.6721;40.5656;115.953;114.587;63.9031;38.3337;197.161 9 84386;24777;360918;24587;58827;24516;79438;114851;24770 SLPI_9890;SLC10A1_9832;PF4_32963;NEFH_33218;MEST_9219;JUN_8938;IGFALS_8880;CDKN1A_8271;CCL2_8218 65.91471333333332 64.0097 28.280797403018923 39.953605555555555 39.4261 14.431079665440071 144.6964888888889 109.875 96.21313142104673 56.5193;7.96762;105.82;79.3182;96.9172;57.7663;70.3663;54.5478;64.0097 39.3315;6.07525;53.8521;39.4261;56.7353;38.6865;46.0459;38.2987;41.1311 100.108;11.4863;109.875;264.141;331.492;109.049;148.796;94.4701;132.851 0 Exp 2,7(0.39);Exp 3,1(0.06);Hill,2(0.12);Linear,6(0.34);Poly 2,2(0.12) 1.9662149037866425 36.27909517288208 1.5230457782745361 3.3687045574188232 0.4946372466543541 1.856894314289093 43.45621025795852 72.55145529759703 28.403806417312715 47.51070469379838 79.50966083046283 158.62378361398163 CONFLICT 0.5 0.5 0.0 GO:0060414 6 aorta smooth muscle tissue morphogenesis 2 2 1 1 1 1 1 1 68 1 2477 0.99928 0.053458 0.053458 50.0 84032 col3a1 COL3A1_8354 57.8774 57.8774 57.8774 57.8774 39.4215 39.4215 39.4215 39.4215 106.603 106.603 106.603 106.603 0.0 57.8774 0.0 57.8774 57.8774 39.4215 106.603 0 1 0 1 84032 COL3A1_8354 57.8774 57.8774 39.4215 39.4215 106.603 106.603 57.8774 39.4215 106.603 0 Exp 2,1(1) 1.589477300643921 1.589477300643921 1.589477300643921 1.589477300643921 0.0 1.589477300643921 57.8774 57.8774 39.4215 39.4215 106.603 106.603 DOWN 0.0 1.0 0.0 GO:0050863 7 regulation of T cell activation 94 99 4 4 3 3 3 3 66 96 2382 0.72061 0.5075 0.74918 3.03 29142;29692;24770 vnn1;pla2g2a;ccl2 VNN1_10157;PLA2G2A_32641;CCL2_8218 28.292700000000384 20.8684 1.16694E-12 32.6443041952186 29.23071337097435 33.53027872105644 19.416833333333724 17.1194 1.16694E-12 20.661570529446955 19.883586333889788 21.231692545672548 53.132800000000394 26.5474 1.16694E-12 70.302451380588 55.69416704735059 72.04102445901171 20.8684;1.16694E-12;64.0097 17.1194;1.16694E-12;41.1311 26.5474;1.16694E-12;132.851 1 2 1 29142 VNN1_10157 20.8684 20.8684 17.1194 17.1194 26.5474 26.5474 20.8684 17.1194 26.5474 2 29692;24770 PLA2G2A_32641;CCL2_8218 32.00485000000058 32.00485000000058 45.26169293171572 20.565550000000584 20.565550000000584 29.084079727661184 66.42550000000058 66.42550000000058 93.9398429874132 1.16694E-12;64.0097 1.16694E-12;41.1311 1.16694E-12;132.851 0 Exp 2,2(0.67);Hill,1(0.34) 2.0161712152179483 6.190566897392273 1.559963583946228 2.642244338989258 0.5450413307412211 1.988358974456787 -8.647807716649893 65.23320771665067 -3.9639347484972873 42.79760141516473 -26.42191288937481 132.68751288937557 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0006464 6 cellular protein modification process 420 450 19 18 16 19 15 15 54 435 2043 0.85477 0.22546 0.34091 3.33 360847;24825;362282;290350;85430;362376;171142;116663;299691;84032;297594;58919;24770;287562;25649 ube2t;tf;pck1;loxl2;herpud1;herc6;ehhadh;dusp6;cry1;col3a1;cdca3;ccnd1;ccl2;ccl12;apoa2 UBE2T_10125;TF_10003;PCK1_9439;LOXL2_9150;HERPUD1_8795;HERC6_8794;EHHADH_8534;DUSP6_8506;CRY1_8386;COL3A1_8354;CDCA3_8260;CCND1_8224;CCL2_8218;CCL12_8217;APOA2_33095 41.00462466666667 45.5478 2.6193 23.183136451234443 43.73182256047357 21.95205792857242 27.520213533333333 33.3115 0.978353 15.66349370314016 28.973948603252534 14.564184286007864 98.31448466666667 86.0232 7.96997 82.30812944284743 120.42285390687327 98.25756989832017 10.9914;51.412;5.51457;65.4434;53.893;53.833;32.6956;45.5478;37.2548;57.8774;2.6193;28.2655;64.0097;25.5289;80.183 7.86591;36.6131;1.34064;43.7615;37.9512;36.3389;25.6436;33.3115;21.8798;39.4215;0.978353;22.3101;41.1311;13.9582;50.2978 18.2059;86.0232;39.6721;129.393;92.6554;98.3689;45.0542;71.7388;73.8251;106.603;7.96997;38.3337;132.851;336.862;197.161 8 7 8 360847;24825;362282;85430;171142;297594;58919;25649 UBE2T_10125;TF_10003;PCK1_9439;HERPUD1_8795;EHHADH_8534;CDCA3_8260;CCND1_8224;APOA2_33095 33.19679625 30.48055 27.22070448923757 22.875087875 23.97685 18.300999226734408 65.63443375 42.363150000000005 60.78374675529846 10.9914;51.412;5.51457;53.893;32.6956;2.6193;28.2655;80.183 7.86591;36.6131;1.34064;37.9512;25.6436;0.978353;22.3101;50.2978 18.2059;86.0232;39.6721;92.6554;45.0542;7.96997;38.3337;197.161 7 290350;362376;116663;299691;84032;24770;287562 LOXL2_9150;HERC6_8794;DUSP6_8506;CRY1_8386;COL3A1_8354;CCL2_8218;CCL12_8217 49.92785714285714 53.833 14.677511871096891 32.82892857142857 36.3389 10.957872013719072 135.6631142857143 106.603 91.90014559452429 65.4434;53.833;45.5478;37.2548;57.8774;64.0097;25.5289 43.7615;36.3389;33.3115;21.8798;39.4215;41.1311;13.9582 129.393;98.3689;71.7388;73.8251;106.603;132.851;336.862 0 Exp 2,5(0.34);Exp 4,1(0.07);Hill,1(0.07);Linear,6(0.4);Poly 2,2(0.14) 1.8391409914081607 27.979809761047363 1.5089621543884277 2.363434076309204 0.3289337541042462 1.8151482343673706 29.272338885237943 52.73691044809539 19.59339203325695 35.44703503340971 56.66082409362137 139.968145239712 CONFLICT 0.5333333333333333 0.4666666666666667 0.0 GO:0051641 3 cellular localization 308 325 7 7 7 7 7 7 62 318 2160 0.32913 0.79695 0.71332 2.15 314654;286918;293502;85430;114851;289054;29657 myo1f;mx2;kif22;herpud1;cdkn1a;aspm;arntl MYO1F_32715;MX2_9268;KIF22_8963;HERPUD1_8795;CDKN1A_8271;ASPM_8092;ARNTL_8086 41.97702857142857 38.2177 10.3235 28.126055276185586 42.90348217521049 23.27435658886894 29.226669999999995 27.1236 7.4611 18.683710538451223 30.1729264099968 15.356071197718016 64.30272857142857 63.2034 16.8623 36.369967800632544 67.11047866087605 31.464586174530258 91.9576;31.6605;13.2391;53.893;54.5478;10.3235;38.2177 61.1322;23.5989;9.02099;37.9512;38.2987;7.4611;27.1236 110.707;46.786;25.4349;92.6554;94.4701;16.8623;63.2034 4 3 4 314654;293502;85430;289054 MYO1F_32715;KIF22_8963;HERPUD1_8795;ASPM_8092 42.353300000000004 33.566050000000004 38.588841151555705 28.8913725 23.486095 25.662164836811638 61.4149 59.04515 47.205841903377454 91.9576;13.2391;53.893;10.3235 61.1322;9.02099;37.9512;7.4611 110.707;25.4349;92.6554;16.8623 3 286918;114851;29657 MX2_9268;CDKN1A_8271;ARNTL_8086 41.47533333333333 38.2177 11.786274072977182 29.67373333333333 27.1236 7.674530280305983 68.15316666666666 63.2034 24.224336745168777 31.6605;54.5478;38.2177 23.5989;38.2987;27.1236 46.786;94.4701;63.2034 0 Exp 2,1(0.15);Linear,2(0.29);Poly 2,3(0.43);Power,1(0.15) 2.006768984864841 15.49371612071991 1.5270863771438599 4.897102355957031 1.249424570565492 1.616806149482727 21.140955237256478 62.81310190560066 15.385583537255583 43.06775646274441 37.359479373696445 91.2459777691607 CONFLICT 0.5714285714285714 0.42857142857142855 0.0 GO:0035026 6 leading edge cell differentiation 2 2 1 1 1 1 1 1 68 1 2477 0.99928 0.053458 0.053458 50.0 24516 jun JUN_8938 57.7663 57.7663 57.7663 57.7663 38.6865 38.6865 38.6865 38.6865 109.049 109.049 109.049 109.049 0.0 57.7663 0.0 57.7663 57.7663 38.6865 109.049 0 1 0 1 24516 JUN_8938 57.7663 57.7663 38.6865 38.6865 109.049 109.049 57.7663 38.6865 109.049 0 Exp 2,1(1) 1.5230457782745361 1.5230457782745361 1.5230457782745361 1.5230457782745361 0.0 1.5230457782745361 57.7663 57.7663 38.6865 38.6865 109.049 109.049 DOWN 0.0 1.0 0.0 GO:0043648 7 dicarboxylic acid metabolic process 32 33 2 2 2 2 2 2 67 31 2447 0.94182 0.22443 0.22443 6.06 362282;29680 pck1;cyp11a1 PCK1_9439;CYP11A1_32785 24.616785 24.616785 5.51457 27.01461152436677 27.576778425897515 26.688314177739617 17.41272 17.41272 1.34064 22.729353511545373 19.903177318195766 22.454815869770353 51.7876 51.7876 39.6721 17.133904414931287 53.66496345504756 16.926951687037576 0.5 24.616785 5.51457;43.719 1.34064;33.4848 39.6721;63.9031 2 0 2 362282;29680 PCK1_9439;CYP11A1_32785 24.616785 24.616785 27.01461152436677 17.41272 17.41272 22.729353511545373 51.7876 51.7876 17.133904414931287 5.51457;43.719 1.34064;33.4848 39.6721;63.9031 0 0 Exp 2,1(0.5);Hill,1(0.5) 2.027330218148832 4.097669363021851 1.752767562866211 2.3449018001556396 0.41870213456007926 2.0488346815109253 -12.823556400000001 62.0571264 -14.088556799999996 48.91399679999999 28.041220000000003 75.53397999999999 UP 1.0 0.0 0.0 GO:0031669 5 cellular response to nutrient levels 87 92 7 7 7 6 6 6 63 86 2392 0.98893 0.036282 0.036282 6.52 78968;362282;24516;114851;24770;25612 srebf1;pck1;jun;cdkn1a;ccl2;asns SREBF1_32750;PCK1_9439;JUN_8938;CDKN1A_8271;CCL2_8218;ASNS_8091 46.45637833333333 56.15705 5.51457 31.4816952082828 56.416738831956586 24.056319528484128 29.683375 38.492599999999996 1.34064 21.346767679205907 37.12265658286443 15.861009705501186 104.18455 101.75955 24.5771 71.98877850139563 119.38556096412466 65.00168254395889 3.5 60.888 11.2357;5.51457;57.7663;54.5478;64.0097;85.6642 4.94421;1.34064;38.6865;38.2987;41.1311;53.6991 24.5771;39.6721;109.049;94.4701;132.851;224.488 3 3 3 78968;362282;25612 SREBF1_32750;PCK1_9439;ASNS_8091 34.13815666666667 11.2357 44.71445726284322 19.99465 4.94421 29.244467708236716 96.24573333333335 39.6721 111.31722227985806 11.2357;5.51457;85.6642 4.94421;1.34064;53.6991 24.5771;39.6721;224.488 3 24516;114851;24770 JUN_8938;CDKN1A_8271;CCL2_8218 58.7746 57.7663 4.810861624491021 39.372099999999996 38.6865 1.535629499586546 112.12336666666666 109.049 19.37426563778198 57.7663;54.5478;64.0097 38.6865;38.2987;41.1311 109.049;94.4701;132.851 0 Exp 2,3(0.5);Hill,2(0.34);Linear,1(0.17) 1.8665508222327967 11.545818328857422 1.5230457782745361 2.857419490814209 0.5507549246891463 1.6302438378334045 21.26577576394907 71.64698090271759 12.602403432548488 46.76434656745151 46.581530318678155 161.78756968132186 CONFLICT 0.5 0.5 0.0 GO:0051248 7 negative regulation of protein metabolic process 294 313 9 9 8 8 7 7 62 306 2172 0.37297 0.76262 0.71131 2.24 84386;24516;85430;116663;299691;114851;29339 slpi;jun;herpud1;dusp6;cry1;cdkn1a;apcs SLPI_9890;JUN_8938;HERPUD1_8795;DUSP6_8506;CRY1_8386;CDKN1A_8271;APCS_8057 58.21185714285714 54.5478 37.2548 20.607817132329256 58.33730739860713 21.869883634838203 38.27968571428571 38.2987 21.8798 10.830694739093566 38.051921241294544 11.668740253912022 133.9239142857143 94.4701 71.7388 116.17959641676084 137.81300170626795 121.85582970714078 56.5193;57.7663;53.893;45.5478;37.2548;54.5478;101.954 39.3315;38.6865;37.9512;33.3115;21.8798;38.2987;58.4986 100.108;109.049;92.6554;71.7388;73.8251;94.4701;395.621 1 6 1 85430 HERPUD1_8795 53.893 53.893 37.9512 37.9512 92.6554 92.6554 53.893 37.9512 92.6554 6 84386;24516;116663;299691;114851;29339 SLPI_9890;JUN_8938;DUSP6_8506;CRY1_8386;CDKN1A_8271;APCS_8057 58.93166666666667 55.533550000000005 22.47812928263084 38.33443333333334 38.492599999999996 11.86337055404855 140.802 97.28905 125.69745668983124 56.5193;57.7663;45.5478;37.2548;54.5478;101.954 39.3315;38.6865;33.3115;21.8798;38.2987;58.4986 100.108;109.049;71.7388;73.8251;94.4701;395.621 0 Exp 2,2(0.29);Linear,5(0.72) 1.6181731120322824 11.351402521133423 1.5230457782745361 1.8622472286224365 0.1175172128858398 1.5823365449905396 42.94537256796609 73.4783417177482 30.25619476869052 46.303176659880904 47.85686481490629 219.9909637565223 DOWN 0.14285714285714285 0.8571428571428571 0.0 GO:0009408 4 response to heat 54 59 3 3 3 2 2 2 67 57 2421 0.78657 0.47939 0.67349 3.39 114851;24770 cdkn1a;ccl2 CDKN1A_8271;CCL2_8218 59.27875 59.27875 54.5478 6.690573652908962 56.89092964597864 5.775846580272329 39.7149 39.7149 38.2987 2.0028092470327894 39.000110964951 1.7289876086159104 113.66055 113.66055 94.4701 27.139394658042768 103.97468413525206 23.428929708913696 54.5478;64.0097 38.2987;41.1311 94.4701;132.851 0 2 0 2 114851;24770 CDKN1A_8271;CCL2_8218 59.27875 59.27875 6.690573652908962 39.7149 39.7149 2.0028092470327894 113.66055 113.66055 27.139394658042768 54.5478;64.0097 38.2987;41.1311 94.4701;132.851 0 Exp 2,1(0.5);Linear,1(0.5) 1.6114057714998768 3.2245079278945923 1.559963583946228 1.6645443439483643 0.07394976457915338 1.6122539639472961 50.00608800000001 68.551412 36.939147999999996 42.490652000000004 76.047268 151.273832 DOWN 0.0 1.0 0.0 GO:0008283 3 cell population proliferation 139 149 5 5 5 5 5 5 64 144 2334 0.78637 0.37838 0.59845 3.36 290350;170568;498709;58919;282840 loxl2;dmbt1;cks2;ccnd1;atf5 LOXL2_9150;DMBT1_32993;CKS2_8325;CCND1_8224;ATF5_8097 45.56566 28.2655 14.4197 35.27311348241036 54.03452802766951 35.92322542732618 32.712599999999995 22.3101 9.6236 27.25747079389429 39.204383054180276 28.024786153828735 94.42229999999999 114.804 29.0958 57.91400205667022 102.68117542399662 52.21777364473109 65.4434;21.7434;14.4197;28.2655;97.9563 43.7615;12.6557;9.6236;22.3101;75.2121 129.393;160.485;29.0958;38.3337;114.804 3 2 3 170568;498709;58919 DMBT1_32993;CKS2_8325;CCND1_8224 21.476200000000002 21.7434 6.926766293877678 14.863133333333332 12.6557 6.625057886791126 75.9715 38.3337 73.33644019714892 21.7434;14.4197;28.2655 12.6557;9.6236;22.3101 160.485;29.0958;38.3337 2 290350;282840 LOXL2_9150;ATF5_8097 81.69985 81.69985 22.990092066040138 59.4868 59.4868 22.238932532385615 122.0985 122.0985 10.315980830730597 65.4434;97.9563 43.7615;75.2121 129.393;114.804 0 Linear,2(0.4);Poly 2,3(0.6) 1.8724270881678455 9.521243572235107 1.530501127243042 2.385996103286743 0.39506112094287554 1.7373461723327637 14.647412826304311 76.48390717369568 8.820373424773791 56.60482657522621 43.65843898447134 145.18616101552868 UP 0.6 0.4 0.0 GO:0006959 4 humoral immune response 62 73 5 5 5 5 5 5 64 68 2410 0.98706 0.045662 0.045662 6.85 84386;360918;170568;287562;29339 slpi;pf4;dmbt1;ccl12;apcs SLPI_9890;PF4_32963;DMBT1_32993;CCL12_8217;APCS_8057 62.313120000000005 56.5193 21.7434 40.301356511251555 55.711692217372594 37.354843368572205 35.659220000000005 39.3315 12.6557 21.59976853642186 33.070924340689736 21.34249050023791 220.5902 160.485 100.108 136.51132143415802 250.6461832544415 138.2652109976385 2.5 79.23665 56.5193;105.82;21.7434;25.5289;101.954 39.3315;53.8521;12.6557;13.9582;58.4986 100.108;109.875;160.485;336.862;395.621 1 4 1 170568 DMBT1_32993 21.7434 21.7434 12.6557 12.6557 160.485 160.485 21.7434 12.6557 160.485 4 84386;360918;287562;29339 SLPI_9890;PF4_32963;CCL12_8217;APCS_8057 72.45555 79.23665 38.46825366667079 41.4101 46.5918 20.039524177817533 235.6165 223.3685 152.78041943150527 56.5193;105.82;25.5289;101.954 39.3315;53.8521;13.9582;58.4986 100.108;109.875;336.862;395.621 0 Exp 3,1(0.2);Linear,2(0.4);Poly 2,2(0.4) 1.632283774723886 8.177966713905334 1.5314651727676392 1.8398383855819702 0.11916059924387229 1.5998332500457764 26.98742348411198 97.63881651588801 16.726188107685427 54.592251892314565 100.93275098536029 340.2476490146397 DOWN 0.2 0.8 0.0 GO:0048731 4 system development 102 110 2 2 2 2 2 2 67 108 2370 0.41984 0.80845 0.76777 1.82 361921;84032 ect2;col3a1 ECT2_8523;COL3A1_8354 36.1458 36.1458 14.4142 30.73312345206715 25.344549306930695 26.668161617384495 24.506925000000003 24.506925000000003 9.59235 21.092394242030704 17.09393821782178 18.3025776544112 68.33914999999999 68.33914999999999 30.0753 54.11325561860978 49.320879999999995 46.95588617052395 14.4142;57.8774 9.59235;39.4215 30.0753;106.603 1 1 1 361921 ECT2_8523 14.4142 14.4142 9.59235 9.59235 30.0753 30.0753 14.4142 9.59235 30.0753 1 84032 COL3A1_8354 57.8774 57.8774 39.4215 39.4215 106.603 106.603 57.8774 39.4215 106.603 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.6819355704163566 3.3692493438720703 1.589477300643921 1.7797720432281494 0.13455870290545646 1.6846246719360352 -6.448135999999998 78.739736 -4.725641999999997 53.739492 -6.657995999999997 143.33629599999998 CONFLICT 0.5 0.5 0.0 GO:0019538 4 protein metabolic process 588 639 26 23 20 23 17 17 52 622 1856 0.53004 0.58191 1.0 2.66 360847;24825;362282;290350;85430;362376;24367;171142;116663;299691;84032;297594;58919;24770;287562;29657;25649 ube2t;tf;pck1;loxl2;herpud1;herc6;fgg;ehhadh;dusp6;cry1;col3a1;cdca3;ccnd1;ccl2;ccl12;arntl;apoa2 UBE2T_10125;TF_10003;PCK1_9439;LOXL2_9150;HERPUD1_8795;HERC6_8794;FGG_8639;EHHADH_8534;DUSP6_8506;CRY1_8386;COL3A1_8354;CDCA3_8260;CCND1_8224;CCL2_8218;CCL12_8217;ARNTL_8086;APOA2_33095 43.90996882352942 45.5478 2.6193 25.13861470486984 44.5301779000206 22.24361364016872 28.897929588235293 33.3115 0.978353 15.751997925517314 29.386238164243682 14.203582356693458 109.72345117647059 86.0232 7.96997 95.63435573536398 121.04541197806729 99.93749689563639 10.9914;51.412;5.51457;65.4434;53.893;53.833;93.1824;32.6956;45.5478;37.2548;57.8774;2.6193;28.2655;64.0097;25.5289;38.2177;80.183 7.86591;36.6131;1.34064;43.7615;37.9512;36.3389;51.338;25.6436;33.3115;21.8798;39.4215;0.978353;22.3101;41.1311;13.9582;27.1236;50.2978 18.2059;86.0232;39.6721;129.393;92.6554;98.3689;327.378;45.0542;71.7388;73.8251;106.603;7.96997;38.3337;132.851;336.862;63.2034;197.161 8 9 8 360847;24825;362282;85430;171142;297594;58919;25649 UBE2T_10125;TF_10003;PCK1_9439;HERPUD1_8795;EHHADH_8534;CDCA3_8260;CCND1_8224;APOA2_33095 33.19679625 30.48055 27.22070448923757 22.875087875 23.97685 18.300999226734408 65.63443375 42.363150000000005 60.78374675529846 10.9914;51.412;5.51457;53.893;32.6956;2.6193;28.2655;80.183 7.86591;36.6131;1.34064;37.9512;25.6436;0.978353;22.3101;50.2978 18.2059;86.0232;39.6721;92.6554;45.0542;7.96997;38.3337;197.161 9 290350;362376;24367;116663;299691;84032;24770;287562;29657 LOXL2_9150;HERC6_8794;FGG_8639;DUSP6_8506;CRY1_8386;COL3A1_8354;CCL2_8218;CCL12_8217;ARNTL_8086 53.43278888888889 53.833 19.969033738356266 34.25156666666667 36.3389 11.604800522413115 148.9136888888889 106.603 106.71142664608888 65.4434;53.833;93.1824;45.5478;37.2548;57.8774;64.0097;25.5289;38.2177 43.7615;36.3389;51.338;33.3115;21.8798;39.4215;41.1311;13.9582;27.1236 129.393;98.3689;327.378;71.7388;73.8251;106.603;132.851;336.862;63.2034 0 Exp 2,6(0.36);Exp 4,1(0.06);Hill,1(0.06);Linear,6(0.36);Poly 2,2(0.12);Power,1(0.06) 1.9524734478509442 34.785810351371765 1.5089621543884277 4.897102355957031 0.7965558634380042 1.8622472286224365 31.95982994874281 55.860107698316 21.40990508986003 36.38595408661057 64.26176421975248 155.1851381331887 CONFLICT 0.47058823529411764 0.5294117647058824 0.0 GO:0071372 7 cellular response to follicle-stimulating hormone stimulus 17 19 2 2 2 2 2 2 67 17 2461 0.98649 0.092012 0.092012 10.53 24825;29680 tf;cyp11a1 TF_10003;CYP11A1_32785 47.5655 47.5655 43.719 5.4397724676681705 49.05052128527157 5.018022326034491 35.048950000000005 35.048950000000005 33.4848 2.2120421435858244 35.65282262273691 2.0405406528706336 74.96315 74.96315 63.9031 15.641272710524584 79.23311221660414 14.42859166178552 0.0 43.719 0.5 47.5655 51.412;43.719 36.6131;33.4848 86.0232;63.9031 2 0 2 24825;29680 TF_10003;CYP11A1_32785 47.5655 47.5655 5.4397724676681705 35.048950000000005 35.048950000000005 2.2120421435858244 74.96315 74.96315 15.641272710524584 51.412;43.719 36.6131;33.4848 86.0232;63.9031 0 0 Exp 2,1(0.5);Linear,1(0.5) 1.874595361521505 3.7576584815979004 1.752767562866211 2.0048909187316895 0.17827813462798897 1.8788292407989502 40.026360000000004 55.104639999999996 31.983216000000002 38.11468400000001 53.285452 96.640848 UP 1.0 0.0 0.0 GO:0071363 6 cellular response to growth factor stimulus 136 141 3 3 3 3 3 3 66 138 2340 0.46248 0.74649 1.0 2.13 79438;29680;24770 igfals;cyp11a1;ccl2 IGFALS_8880;CYP11A1_32785;CCL2_8218 59.365 64.0097 43.719 13.917599573561526 64.3662574933804 11.744308065301814 40.220600000000005 41.1311 33.4848 6.329855131833565 42.74263396293028 5.649419444643646 115.18336666666666 132.851 63.9031 45.119951998016724 130.74708889673434 37.435665437175004 70.3663;43.719;64.0097 46.0459;33.4848;41.1311 148.796;63.9031;132.851 1 2 1 29680 CYP11A1_32785 43.719 43.719 33.4848 33.4848 63.9031 63.9031 43.719 33.4848 63.9031 2 79438;24770 IGFALS_8880;CCL2_8218 67.18799999999999 67.18799999999999 4.49479496529079 43.5885 43.5885 3.475288408175687 140.8235 140.8235 11.274817626019253 70.3663;64.0097 46.0459;41.1311 148.796;132.851 0 Exp 2,2(0.67);Linear,1(0.34) 1.6104507589409438 4.840309739112854 1.527578592300415 1.752767562866211 0.12174579694029104 1.559963583946228 43.61575347387243 75.11424652612756 33.0576946139809 47.383505386019095 64.12533446018588 166.24139887314743 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0048869 3 cellular developmental process 541 573 26 25 23 22 20 20 49 553 1925 0.92387 0.12391 0.19011 3.49 360243;24825;78968;362282;24587;366960;290350;24516;362376;24440;360504;24367;116663;170568;29680;114851;58919;282840;289054;29657 top2a;tf;srebf1;pck1;nefh;maff;loxl2;jun;herc6;hbb;hba-a2;fgg;dusp6;dmbt1;cyp11a1;cdkn1a;ccnd1;atf5;aspm;arntl TOP2A_10059;TF_10003;SREBF1_32750;PCK1_9439;NEFH_33218;MAFF_9172;LOXL2_9150;JUN_8938;HERC6_8794;HBB_8782;HBA2_32600;FGG_8639;DUSP6_8506;DMBT1_32993;CYP11A1_32785;CDKN1A_8271;CCND1_8224;ATF5_8097;ASPM_8092;ARNTL_8086 51.138473499999996 52.6225 5.51457 30.427411453534404 54.444933896636684 25.586902467843668 34.5560945 36.476 1.34064 21.84511509532593 36.74753745747645 18.09225107789312 111.39099500000002 96.4195 16.8623 86.2813404530445 114.23283820694087 74.75772704285133 13.8391;51.412;11.2357;5.51457;79.3182;58.0695;65.4434;57.7663;53.833;91.4283;101.406;93.1824;45.5478;21.7434;43.719;54.5478;28.2655;97.9563;10.3235;38.2177 9.31624;36.6131;4.94421;1.34064;39.4261;40.1293;43.7615;38.6865;36.3389;54.7263;84.6435;51.338;33.3115;12.6557;33.4848;38.2987;22.3101;75.2121;7.4611;27.1236 27.6952;86.0232;24.5771;39.6721;264.141;104.733;129.393;109.049;98.3689;277.036;115.953;327.378;71.7388;160.485;63.9031;94.4701;38.3337;114.804;16.8623;63.2034 10 10 10 360243;24825;78968;362282;366960;360504;170568;29680;58919;289054 TOP2A_10059;TF_10003;SREBF1_32750;PCK1_9439;MAFF_9172;HBA2_32600;DMBT1_32993;CYP11A1_32785;CCND1_8224;ASPM_8092 34.552827 25.00445 29.809153228824062 25.289869 17.4829 25.094198458784344 67.82377 51.7876 47.55258757249822 13.8391;51.412;11.2357;5.51457;58.0695;101.406;21.7434;43.719;28.2655;10.3235 9.31624;36.6131;4.94421;1.34064;40.1293;84.6435;12.6557;33.4848;22.3101;7.4611 27.6952;86.0232;24.5771;39.6721;104.733;115.953;160.485;63.9031;38.3337;16.8623 10 24587;290350;24516;362376;24440;24367;116663;114851;282840;29657 NEFH_33218;LOXL2_9150;JUN_8938;HERC6_8794;HBB_8782;FGG_8639;DUSP6_8506;CDKN1A_8271;ATF5_8097;ARNTL_8086 67.72412 61.60485 21.322330613326532 43.822320000000005 39.0563 13.671723251928904 154.95822 111.9265 96.10851815036769 79.3182;65.4434;57.7663;53.833;91.4283;93.1824;45.5478;54.5478;97.9563;38.2177 39.4261;43.7615;38.6865;36.3389;54.7263;51.338;33.3115;38.2987;75.2121;27.1236 264.141;129.393;109.049;98.3689;277.036;327.378;71.7388;94.4701;114.804;63.2034 0 Exp 2,5(0.25);Hill,2(0.1);Linear,7(0.35);Poly 2,5(0.25);Power,1(0.05) 1.9422872521427723 40.58272933959961 1.5089621543884277 4.897102355957031 0.758483771898073 1.7726113200187683 37.80307246366611 64.4738745363339 24.982050683426717 44.130138316573294 73.57653028120923 149.2054597187908 CONFLICT 0.5 0.5 0.0 GO:0051346 6 negative regulation of hydrolase activity 118 128 5 5 5 4 4 4 65 124 2354 0.73576 0.46024 0.7763 3.12 84386;85430;25649;29339 slpi;herpud1;apoa2;apcs SLPI_9890;HERPUD1_8795;APOA2_33095;APCS_8057 73.137325 68.35115 53.893 22.557667535064425 76.25026395886337 21.94723596841934 46.519775 44.81465 37.9512 9.710089190930928 47.92992371448023 9.393263901818322 196.38635 148.6345 92.6554 141.09651130800506 211.81511061740778 140.37233216787024 56.5193;53.893;80.183;101.954 39.3315;37.9512;50.2978;58.4986 100.108;92.6554;197.161;395.621 2 2 2 85430;25649 HERPUD1_8795;APOA2_33095 67.03800000000001 67.03800000000001 18.58983727739426 44.1245 44.1245 8.73036458459786 144.9082 144.9082 73.89661843196888 53.893;80.183 37.9512;50.2978 92.6554;197.161 2 84386;29339 SLPI_9890;APCS_8057 79.23665 79.23665 32.127184471176434 48.91505 48.91505 13.553186385680698 247.8645 247.8645 208.95924622878022 56.5193;101.954 39.3315;58.4986 100.108;395.621 0 Linear,4(1) 1.6678486833686093 6.705186605453491 1.5270863771438599 1.9712703227996826 0.2006533123782882 1.6034149527549744 51.03081081563686 95.24383918436314 37.00388759288771 56.0356624071123 58.111768918155036 334.660931081845 CONFLICT 0.5 0.5 0.0 GO:2000431 6 regulation of cytokinesis, actomyosin contractile ring assembly 1 1 1 1 1 1 1 1 68 0 2478 1.0 0.027091 0.027091 100.0 361921 ect2 ECT2_8523 14.4142 14.4142 14.4142 14.4142 9.59235 9.59235 9.59235 9.59235 30.0753 30.0753 30.0753 30.0753 0.0 14.4142 0.0 14.4142 14.4142 9.59235 30.0753 1 0 1 361921 ECT2_8523 14.4142 14.4142 9.59235 9.59235 30.0753 30.0753 14.4142 9.59235 30.0753 0 0 Poly 2,1(1) 1.7797720432281494 1.7797720432281494 1.7797720432281494 1.7797720432281494 0.0 1.7797720432281494 14.4142 14.4142 9.59235 9.59235 30.0753 30.0753 UP 1.0 0.0 0.0 GO:0007019 6 microtubule depolymerization 5 5 1 1 1 1 1 1 68 4 2474 0.99314 0.12841 0.12841 20.0 303575 kif18b KIF18B_32882 3.6768 3.6768 3.6768 3.6768 1.12034 1.12034 1.12034 1.12034 11.7489 11.7489 11.7489 11.7489 0.0 3.6768 0.0 3.6768 3.6768 1.12034 11.7489 1 0 1 303575 KIF18B_32882 3.6768 3.6768 1.12034 1.12034 11.7489 11.7489 3.6768 1.12034 11.7489 0 0 Exp 4,1(1) 1.8689792156219482 1.8689792156219482 1.8689792156219482 1.8689792156219482 0.0 1.8689792156219482 3.6768 3.6768 1.12034 1.12034 11.7489 11.7489 UP 1.0 0.0 0.0 GO:0048518 4 positive regulation of biological process 1152 1238 47 46 42 40 37 37 32 1201 1277 0.83333 0.23473 0.46407 2.99 29142;360243;24825;78968;29692;360918;362282;316351;114519;314654;366960;290350;24516;85430;24440;360504;81660;24367;361921;116663;170568;24309;299691;84032;498709;306575;114851;58919;24770;287562;282840;289054;25612;29657;25649;29339;81639 vnn1;top2a;tf;srebf1;pla2g2a;pf4;pck1;npas2;nfil3;myo1f;maff;loxl2;jun;herpud1;hbb;hba-a2;gatm;fgg;ect2;dusp6;dmbt1;dbp;cry1;col3a1;cks2;ckap2;cdkn1a;ccnd1;ccl2;ccl12;atf5;aspm;asns;arntl;apoa2;apcs;alox15 VNN1_10157;TOP2A_10059;TF_10003;SREBF1_32750;PLA2G2A_32641;PF4_32963;PCK1_9439;NPAS2_9350;NFIL3_9304;MYO1F_32715;MAFF_9172;LOXL2_9150;JUN_8938;HERPUD1_8795;HBB_8782;HBA2_32600;GATM_32792;FGG_8639;ECT2_8523;DUSP6_8506;DMBT1_32993;DBP_8439;CRY1_8386;COL3A1_8354;CKS2_8325;CKAP2_8324;CDKN1A_8271;CCND1_8224;CCL2_8218;CCL12_8217;ATF5_8097;ASPM_8092;ASNS_8091;ARNTL_8086;APOA2_33095;APCS_8057;ALOX15_8036 51.269034324324345 51.412 1.16694E-12 32.64193743725291 54.474846939324934 29.773884901363058 34.38767243243246 36.6131 1.16694E-12 22.347892650922255 36.72671385021025 20.73632462509979 110.26631891891897 94.4701 1.16694E-12 94.45914792284785 126.65229920112127 100.68495064283643 20.8684;13.8391;51.412;11.2357;1.16694E-12;105.82;5.51457;58.2312;33.1149;91.9576;58.0695;65.4434;57.7663;53.893;91.4283;101.406;37.423;93.1824;14.4142;45.5478;21.7434;50.6952;37.2548;57.8774;14.4197;12.1218;54.5478;28.2655;64.0097;25.5289;97.9563;10.3235;85.6642;38.2177;80.183;101.954;105.624 17.1194;9.31624;36.6131;4.94421;1.16694E-12;53.8521;1.34064;35.795;25.603;61.1322;40.1293;43.7615;38.6865;37.9512;54.7263;84.6435;28.03;51.338;9.59235;33.3115;12.6557;40.5862;21.8798;39.4215;9.6236;8.47044;38.2987;22.3101;41.1311;13.9582;75.2121;7.4611;53.6991;27.1236;50.2978;58.4986;83.8302 26.5474;27.6952;86.0232;24.5771;1.16694E-12;109.875;39.6721;99.4319;46.6318;110.707;104.733;129.393;109.049;92.6554;277.036;115.953;55.6613;327.378;30.0753;71.7388;160.485;59.5346;73.8251;106.603;29.0958;21.3803;94.4701;38.3337;132.851;336.862;114.804;16.8623;224.488;63.2034;197.161;395.621;129.44 18 19 18 29142;360243;24825;78968;362282;314654;366960;85430;360504;361921;170568;498709;306575;58919;289054;25612;25649;81639 VNN1_10157;TOP2A_10059;TF_10003;SREBF1_32750;PCK1_9439;MYO1F_32715;MAFF_9172;HERPUD1_8795;HBA2_32600;ECT2_8523;DMBT1_32993;CKS2_8325;CKAP2_8324;CCND1_8224;ASPM_8092;ASNS_8091;APOA2_33095;ALOX15_8036 43.38639833333333 25.00445 35.500575614827014 30.618343333333332 19.71475 26.827523163979542 81.9936 62.84765 64.63983041462721 20.8684;13.8391;51.412;11.2357;5.51457;91.9576;58.0695;53.893;101.406;14.4142;21.7434;14.4197;12.1218;28.2655;10.3235;85.6642;80.183;105.624 17.1194;9.31624;36.6131;4.94421;1.34064;61.1322;40.1293;37.9512;84.6435;9.59235;12.6557;9.6236;8.47044;22.3101;7.4611;53.6991;50.2978;83.8302 26.5474;27.6952;86.0232;24.5771;39.6721;110.707;104.733;92.6554;115.953;30.0753;160.485;29.0958;21.3803;38.3337;16.8623;224.488;197.161;129.44 19 29692;360918;316351;114519;290350;24516;24440;81660;24367;116663;24309;299691;84032;114851;24770;287562;282840;29657;29339 PLA2G2A_32641;PF4_32963;NPAS2_9350;NFIL3_9304;LOXL2_9150;JUN_8938;HBB_8782;GATM_32792;FGG_8639;DUSP6_8506;DBP_8439;CRY1_8386;COL3A1_8354;CDKN1A_8271;CCL2_8218;CCL12_8217;ATF5_8097;ARNTL_8086;APCS_8057 58.736794736842164 57.7663 28.630680441665046 37.958615789473754 38.6865 17.072109780843608 137.05100000000004 106.603 111.09572172773643 1.16694E-12;105.82;58.2312;33.1149;65.4434;57.7663;91.4283;37.423;93.1824;45.5478;50.6952;37.2548;57.8774;54.5478;64.0097;25.5289;97.9563;38.2177;101.954 1.16694E-12;53.8521;35.795;25.603;43.7615;38.6865;54.7263;28.03;51.338;33.3115;40.5862;21.8798;39.4215;38.2987;41.1311;13.9582;75.2121;27.1236;58.4986 1.16694E-12;109.875;99.4319;46.6318;129.393;109.049;277.036;55.6613;327.378;71.7388;59.5346;73.8251;106.603;94.4701;132.851;336.862;114.804;63.2034;395.621 0 Exp 2,8(0.22);Exp 3,1(0.03);Hill,3(0.09);Linear,11(0.3);Poly 2,12(0.33);Power,2(0.06) 2.0152693506577077 79.6353634595871 1.5230457782745361 5.737884044647217 0.9793766088222895 1.8216042518615723 40.7510834659207 61.786985182728 27.186689428800385 41.58865543606456 79.82950192884243 140.70313590899553 CONFLICT 0.4864864864864865 0.5135135135135135 0.0 GO:0070482 4 response to oxygen levels 182 189 8 7 7 7 6 6 63 183 2295 0.75169 0.40596 0.63982 3.17 24825;362282;299923;290350;114851;24770 tf;pck1;ndrg1;loxl2;cdkn1a;ccl2 TF_10003;PCK1_9439;NDRG1_32364;LOXL2_9150;CDKN1A_8271;CCL2_8218 56.76526166666667 59.27875 5.51457 30.424694723444905 67.25164595154537 24.97326553120223 33.94994 39.7149 1.34064 16.194113273087865 39.044698918852355 9.134629338050154 97.96973333333334 99.93955 39.6721 34.09706229349777 104.6293622922054 23.214576514287053 51.412;5.51457;99.6641;65.4434;54.5478;64.0097 36.6131;1.34064;42.5546;43.7615;38.2987;41.1311 86.0232;39.6721;105.409;129.393;94.4701;132.851 2 4 2 24825;362282 TF_10003;PCK1_9439 28.463285 28.463285 32.45438399203488 18.97687 18.97687 24.941395655131252 62.84765 62.84765 32.77517712545579 51.412;5.51457 36.6131;1.34064 86.0232;39.6721 4 299923;290350;114851;24770 NDRG1_32364;LOXL2_9150;CDKN1A_8271;CCL2_8218 70.91625 64.72655 19.765437469228946 41.436475 41.84285 2.3519375422191606 115.530775 117.40100000000001 18.60245357121381 99.6641;65.4434;54.5478;64.0097 42.5546;43.7615;38.2987;41.1311 105.409;129.393;94.4701;132.851 0 Exp 2,1(0.17);Exp 3,1(0.17);Hill,1(0.17);Linear,3(0.5) 1.7845073332146906 10.834290981292725 1.5226441621780396 2.3449018001556396 0.31480780184386536 1.700945258140564 32.42043563355331 81.11008769978001 20.99195064374011 46.907929356259885 70.68640124665914 125.25306542000753 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:2001237 8 negative regulation of extrinsic apoptotic signaling pathway 46 48 2 2 2 2 2 2 67 46 2432 0.86089 0.37569 0.37569 4.17 360918;24367 pf4;fgg PF4_32963;FGG_8639 99.5012 99.5012 93.1824 8.936132657923038 99.20462796934866 8.926284610142805 52.59505 52.59505 51.338 1.7777371585809807 52.53605052681993 1.7757780067698832 218.6265 218.6265 109.875 153.7978462284176 223.73073706896554 153.6283536082698 105.82;93.1824 53.8521;51.338 109.875;327.378 0 2 0 2 360918;24367 PF4_32963;FGG_8639 99.5012 99.5012 8.936132657923038 52.59505 52.59505 1.7777371585809807 218.6265 218.6265 153.7978462284176 105.82;93.1824 53.8521;51.338 109.875;327.378 0 Exp 2,1(0.5);Exp 3,1(0.5) 1.8740502249829745 3.748736619949341 1.8398383855819702 1.9088982343673706 0.048832687383874175 1.8743683099746704 87.116352 111.88604799999999 50.131232000000004 55.058868 5.47356000000002 431.77943999999997 DOWN 0.0 1.0 0.0 GO:0048545 5 response to steroid hormone 158 177 12 12 12 10 10 10 59 167 2311 0.99302 0.019013 0.025488 5.65 78968;362282;79438;24450;316033;29680;114851;58919;24770;25649 srebf1;pck1;igfals;hmgcs2;glb1;cyp11a1;cdkn1a;ccnd1;ccl2;apoa2 SREBF1_32750;PCK1_9439;IGFALS_8880;HMGCS2_8812;GLB1_8712;CYP11A1_32785;CDKN1A_8271;CCND1_8224;CCL2_8218;APOA2_33095 45.435596999999994 49.1334 5.51457 25.72852731295407 52.248581022422876 23.35285471423285 31.028755 35.89175 1.34064 17.385754211497567 35.56320024863908 14.180660603224956 89.49167 79.1866 24.5771 57.74065015086473 104.25198648362567 62.97963903171231 7.5 68.1411 11.2357;5.51457;70.3663;30.5985;65.9159;43.719;54.5478;28.2655;64.0097;80.183 4.94421;1.34064;46.0459;24.577;47.8573;33.4848;38.2987;22.3101;41.1311;50.2978 24.5771;39.6721;148.796;40.5656;114.587;63.9031;94.4701;38.3337;132.851;197.161 7 3 7 78968;362282;24450;316033;29680;58919;25649 SREBF1_32750;PCK1_9439;HMGCS2_8812;GLB1_8712;CYP11A1_32785;CCND1_8224;APOA2_33095 37.918881428571424 30.5985 27.424251647421137 26.401692857142855 24.577 19.105357007278283 74.11422857142858 40.5656 61.81796443903433 11.2357;5.51457;30.5985;65.9159;43.719;28.2655;80.183 4.94421;1.34064;24.577;47.8573;33.4848;22.3101;50.2978 24.5771;39.6721;40.5656;114.587;63.9031;38.3337;197.161 3 79438;114851;24770 IGFALS_8880;CDKN1A_8271;CCL2_8218 62.9746 64.0097 7.9598875350095195 41.82523333333334 41.1311 3.9199671903388675 125.37236666666666 132.851 27.92442157150864 70.3663;54.5478;64.0097 46.0459;38.2987;41.1311 148.796;94.4701;132.851 0 Exp 2,4(0.4);Hill,2(0.2);Linear,4(0.4) 2.078523740274295 21.46029508113861 1.527578592300415 3.3687045574188232 0.5961273367860547 2.0584241151809692 29.488890558445828 61.38230344155417 20.252952898953367 41.804557101046626 53.70364426108721 125.27969573891278 UP 0.7 0.3 0.0 GO:0080134 5 regulation of response to stress 340 358 19 19 15 18 14 14 55 344 2134 0.94833 0.094906 0.15704 3.91 29142;24825;84386;287877;316351;314654;85430;24440;24367;299691;114851;24770;29657;81639 vnn1;tf;slpi;pycr1;npas2;myo1f;herpud1;hbb;fgg;cry1;cdkn1a;ccl2;arntl;alox15 VNN1_10157;TF_10003;SLPI_9890;PYCR1_9631;NPAS2_9350;MYO1F_32715;HERPUD1_8795;HBB_8782;FGG_8639;CRY1_8386;CDKN1A_8271;CCL2_8218;ARNTL_8086;ALOX15_8036 62.275600000000004 55.615750000000006 20.8684 24.56123160116676 59.54796263326735 22.665355276646647 41.76112142857143 38.34215 17.1194 16.934015950795995 40.77102900006826 17.429205089460975 122.04334285714285 97.1811 26.5474 81.35422360507278 106.26256171182852 58.10082256815756 20.8684;51.412;56.5193;54.7122;58.2312;91.9576;53.893;91.4283;93.1824;37.2548;54.5478;64.0097;38.2177;105.624 17.1194;36.6131;39.3315;38.3856;35.795;61.1322;37.9512;54.7263;51.338;21.8798;38.2987;41.1311;27.1236;83.8302 26.5474;86.0232;100.108;94.9303;99.4319;110.707;92.6554;277.036;327.378;73.8251;94.4701;132.851;63.2034;129.44 6 8 6 29142;24825;287877;314654;85430;81639 VNN1_10157;TF_10003;PYCR1_9631;MYO1F_32715;HERPUD1_8795;ALOX15_8036 63.07786666666667 54.3026 30.712506035337874 45.83861666666667 38.1684 23.259047522064762 90.05055 93.79285 34.80713866273699 20.8684;51.412;54.7122;91.9576;53.893;105.624 17.1194;36.6131;38.3856;61.1322;37.9512;83.8302 26.5474;86.0232;94.9303;110.707;92.6554;129.44 8 84386;316351;24440;24367;299691;114851;24770;29657 SLPI_9890;NPAS2_9350;HBB_8782;FGG_8639;CRY1_8386;CDKN1A_8271;CCL2_8218;ARNTL_8086 61.6739 57.37525 21.109425796345764 38.702999999999996 38.8151 11.009103602019588 146.0379375 99.76995 99.45263353846877 56.5193;58.2312;91.4283;93.1824;37.2548;54.5478;64.0097;38.2177 39.3315;35.795;54.7263;51.338;21.8798;38.2987;41.1311;27.1236 100.108;99.4319;277.036;327.378;73.8251;94.4701;132.851;63.2034 0 Exp 2,4(0.29);Linear,6(0.43);Poly 2,2(0.15);Power,2(0.15) 2.0412951011187523 31.163477301597595 1.5270863771438599 4.897102355957031 1.1509747232263032 1.7233816385269165 49.40964008917203 75.14155991082798 32.89054140676533 50.63170145037753 79.42739441953773 164.65929129474796 CONFLICT 0.42857142857142855 0.5714285714285714 0.0 GO:0042127 5 regulation of cell population proliferation 436 466 17 17 14 12 11 11 58 455 2023 0.37211 0.74292 0.75215 2.36 24825;29692;360918;299923;24516;114851;58919;24770;287562;282840;289054 tf;pla2g2a;pf4;ndrg1;jun;cdkn1a;ccnd1;ccl2;ccl12;atf5;aspm TF_10003;PLA2G2A_32641;PF4_32963;NDRG1_32364;JUN_8938;CDKN1A_8271;CCND1_8224;CCL2_8218;CCL12_8217;ATF5_8097;ASPM_8092 54.11764545454557 54.5478 1.16694E-12 36.222103900584166 57.18894268867929 33.88457687748281 33.643418181818284 38.2987 1.16694E-12 21.589556018307295 35.70757426771347 21.187981137146576 104.04902727272739 105.409 1.16694E-12 88.52728990363455 126.65539850573957 101.75184377572668 51.412;1.16694E-12;105.82;99.6641;57.7663;54.5478;28.2655;64.0097;25.5289;97.9563;10.3235 36.6131;1.16694E-12;53.8521;42.5546;38.6865;38.2987;22.3101;41.1311;13.9582;75.2121;7.4611 86.0232;1.16694E-12;109.875;105.409;109.049;94.4701;38.3337;132.851;336.862;114.804;16.8623 3 8 3 24825;58919;289054 TF_10003;CCND1_8224;ASPM_8092 30.000333333333334 28.2655 20.599112677087163 22.1281 22.3101 14.576852163618868 47.07306666666667 38.3337 35.399010148637394 51.412;28.2655;10.3235 36.6131;22.3101;7.4611 86.0232;38.3337;16.8623 8 29692;360918;299923;24516;114851;24770;287562;282840 PLA2G2A_32641;PF4_32963;NDRG1_32364;JUN_8938;CDKN1A_8271;CCL2_8218;CCL12_8217;ATF5_8097 63.16163750000015 60.888 37.55467757603305 37.961662500000145 39.9088 22.956899125655525 125.41501250000016 109.462 94.47131679510562 1.16694E-12;105.82;99.6641;57.7663;54.5478;64.0097;25.5289;97.9563 1.16694E-12;53.8521;42.5546;38.6865;38.2987;41.1311;13.9582;75.2121 1.16694E-12;109.875;105.409;109.049;94.4701;132.851;336.862;114.804 0 Exp 2,2(0.19);Exp 3,2(0.19);Hill,1(0.1);Linear,3(0.28);Poly 2,3(0.28) 1.7791847581932185 19.833597779273987 1.5226441621780396 2.385996103286743 0.3174178988761265 1.6645443439483643 32.71174996356441 75.52354094552672 20.884805896541394 46.40203046709517 51.732742139813524 156.36531240564125 DOWN 0.2727272727272727 0.7272727272727273 0.0 GO:0002683 5 negative regulation of immune system process 126 135 8 8 7 7 7 7 62 128 2350 0.9726 0.069885 0.092027 5.19 29692;360918;84032;24770;25649;29339;81639 pla2g2a;pf4;col3a1;ccl2;apoa2;apcs;alox15 PLA2G2A_32641;PF4_32963;COL3A1_8354;CCL2_8218;APOA2_33095;APCS_8057;ALOX15_8036 73.63830000000017 80.183 1.16694E-12 38.00674044960057 83.34955164466474 31.742798727173994 46.718757142857314 50.2978 1.16694E-12 25.320716682514586 54.04791727760194 23.214350690624357 153.07871428571448 129.44 1.16694E-12 121.92730294826514 200.1167945815435 132.1387241656566 5.5 105.722 1.16694E-12;105.82;57.8774;64.0097;80.183;101.954;105.624 1.16694E-12;53.8521;39.4215;41.1311;50.2978;58.4986;83.8302 1.16694E-12;109.875;106.603;132.851;197.161;395.621;129.44 2 5 2 25649;81639 APOA2_33095;ALOX15_8036 92.90350000000001 92.90350000000001 17.989503620166875 67.06400000000001 67.06400000000001 23.710987429459763 163.3005 163.3005 47.8859783287342 80.183;105.624 50.2978;83.8302 197.161;129.44 5 29692;360918;84032;24770;29339 PLA2G2A_32641;PF4_32963;COL3A1_8354;CCL2_8218;APCS_8057 65.93222000000023 64.0097 42.73241588714546 38.580660000000236 41.1311 23.05222492326885 148.99000000000024 109.875 147.14956555831182 1.16694E-12;105.82;57.8774;64.0097;101.954 1.16694E-12;53.8521;39.4215;41.1311;58.4986 1.16694E-12;109.875;106.603;132.851;395.621 0 Exp 2,2(0.29);Exp 3,1(0.15);Hill,1(0.15);Linear,2(0.29);Poly 2,1(0.15) 1.7443110171006815 12.26485550403595 1.559963583946228 1.988358974456787 0.180220208888189 1.6914535760879517 45.48251265532992 101.79408734467043 27.96090772209707 65.47660656361757 62.753704229330665 243.40372434209826 DOWN 0.2857142857142857 0.7142857142857143 0.0 GO:0046474 6 glycerophospholipid biosynthetic process 21 23 2 2 2 2 2 2 67 21 2457 0.97714 0.12717 0.12717 8.7 25649;81639 apoa2;alox15 APOA2_33095;ALOX15_8036 92.90350000000001 92.90350000000001 80.183 17.989503620166875 91.17865841133646 17.823357806205653 67.06400000000001 67.06400000000001 50.2978 23.710987429459763 64.79058000520021 23.491999658064227 163.3005 163.3005 129.44 47.8859783287342 167.8918288481539 47.44371738508945 0.5 92.90350000000001 80.183;105.624 50.2978;83.8302 197.161;129.44 2 0 2 25649;81639 APOA2_33095;ALOX15_8036 92.90350000000001 92.90350000000001 17.989503620166875 67.06400000000001 67.06400000000001 23.710987429459763 163.3005 163.3005 47.8859783287342 80.183;105.624 50.2978;83.8302 197.161;129.44 0 0 Linear,1(0.5);Poly 2,1(0.5) 1.8260099224636142 3.6627238988876343 1.6914535760879517 1.9712703227996826 0.19786031908942353 1.8313619494438171 67.97132000000002 117.83568 34.202248000000004 99.92575200000002 96.93392 229.66708 UP 1.0 0.0 0.0 GO:0007154 3 cell communication 162 169 9 9 8 7 7 7 62 162 2316 0.91685 0.16984 0.21941 4.14 78968;362282;24516;114851;24770;287562;25612 srebf1;pck1;jun;cdkn1a;ccl2;ccl12;asns SREBF1_32750;PCK1_9439;JUN_8938;CDKN1A_8271;CCL2_8218;CCL12_8217;ASNS_8091 43.46673857142857 54.5478 5.51457 29.807379941849085 47.86709201414141 25.094046828249486 27.436921428571427 38.2987 1.34064 20.373093796273253 30.710815223953826 17.383937535465662 137.4241857142857 109.049 24.5771 109.78509553683249 179.58228612409812 118.39125865432179 11.2357;5.51457;57.7663;54.5478;64.0097;25.5289;85.6642 4.94421;1.34064;38.6865;38.2987;41.1311;13.9582;53.6991 24.5771;39.6721;109.049;94.4701;132.851;336.862;224.488 3 4 3 78968;362282;25612 SREBF1_32750;PCK1_9439;ASNS_8091 34.13815666666667 11.2357 44.71445726284322 19.99465 4.94421 29.244467708236716 96.24573333333335 39.6721 111.31722227985806 11.2357;5.51457;85.6642 4.94421;1.34064;53.6991 24.5771;39.6721;224.488 4 24516;114851;24770;287562 JUN_8938;CDKN1A_8271;CCL2_8218;CCL12_8217 50.46317500000001 56.15705 17.080653827332426 33.018625 38.492599999999996 12.768660211986479 168.308025 120.95 113.47733154307006 57.7663;54.5478;64.0097;25.5289 38.6865;38.2987;41.1311;13.9582 109.049;94.4701;132.851;336.862 0 Exp 2,3(0.43);Hill,2(0.29);Linear,1(0.15);Poly 2,1(0.15) 1.8145281919778218 13.077283501625061 1.5230457782745361 2.857419490814209 0.524234456745087 1.5959433317184448 21.38512249447524 65.5483546483819 12.344322334430519 42.529520522712346 56.09424878774651 218.75412264082496 CONFLICT 0.42857142857142855 0.5714285714285714 0.0 GO:0006508 5 proteolysis 170 184 6 5 4 4 3 3 66 181 2297 0.25291 0.88672 0.48052 1.63 85430;24367;29657 herpud1;fgg;arntl HERPUD1_8795;FGG_8639;ARNTL_8086 61.76436666666667 53.893 38.2177 28.315161511517697 52.04640524846455 24.558503576060367 38.80426666666667 37.9512 27.1236 12.129719036042568 34.27781395868231 11.144560755434323 161.07893333333334 92.6554 63.2034 144.7701272937664 117.24146457685254 119.26857424343379 53.893;93.1824;38.2177 37.9512;51.338;27.1236 92.6554;327.378;63.2034 1 2 1 85430 HERPUD1_8795 53.893 53.893 37.9512 37.9512 92.6554 92.6554 53.893 37.9512 92.6554 2 24367;29657 FGG_8639;ARNTL_8086 65.70005 65.70005 38.86591209588424 39.2308 39.2308 17.122166442363515 195.2907 195.2907 186.79965107724368 93.1824;38.2177 51.338;27.1236 327.378;63.2034 0 Exp 2,1(0.34);Linear,1(0.34);Power,1(0.34) 2.4258383277562645 8.333086967468262 1.5270863771438599 4.897102355957031 1.8453613857479696 1.9088982343673706 29.72274506985461 93.80598826347872 25.07819742738541 52.53033590594792 -2.7438877154646377 324.90175438213134 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0006529 7 asparagine biosynthetic process 1 1 1 1 1 1 1 1 68 0 2478 1.0 0.027091 0.027091 100.0 25612 asns ASNS_8091 85.6642 85.6642 85.6642 85.6642 53.6991 53.6991 53.6991 53.6991 224.488 224.488 224.488 224.488 0.0 85.6642 0.0 85.6642 85.6642 53.6991 224.488 1 0 1 25612 ASNS_8091 85.6642 85.6642 53.6991 53.6991 224.488 224.488 85.6642 53.6991 224.488 0 0 Exp 2,1(1) 1.5959433317184448 1.5959433317184448 1.5959433317184448 1.5959433317184448 0.0 1.5959433317184448 85.6642 85.6642 53.6991 53.6991 224.488 224.488 UP 1.0 0.0 0.0 GO:0070981 7 L-asparagine biosynthetic process 1 1 1 1 1 1 1 1 68 0 2478 1.0 0.027091 0.027091 100.0 25612 asns ASNS_8091 85.6642 85.6642 85.6642 85.6642 53.6991 53.6991 53.6991 53.6991 224.488 224.488 224.488 224.488 0.0 85.6642 0.0 85.6642 85.6642 53.6991 224.488 1 0 1 25612 ASNS_8091 85.6642 85.6642 53.6991 53.6991 224.488 224.488 85.6642 53.6991 224.488 0 0 Exp 2,1(1) 1.5959433317184448 1.5959433317184448 1.5959433317184448 1.5959433317184448 0.0 1.5959433317184448 85.6642 85.6642 53.6991 53.6991 224.488 224.488 UP 1.0 0.0 0.0 GO:0070982 7 L-asparagine metabolic process 1 1 1 1 1 1 1 1 68 0 2478 1.0 0.027091 0.027091 100.0 25612 asns ASNS_8091 85.6642 85.6642 85.6642 85.6642 53.6991 53.6991 53.6991 53.6991 224.488 224.488 224.488 224.488 0.0 85.6642 0.0 85.6642 85.6642 53.6991 224.488 1 0 1 25612 ASNS_8091 85.6642 85.6642 53.6991 53.6991 224.488 224.488 85.6642 53.6991 224.488 0 0 Exp 2,1(1) 1.5959433317184448 1.5959433317184448 1.5959433317184448 1.5959433317184448 0.0 1.5959433317184448 85.6642 85.6642 53.6991 53.6991 224.488 224.488 UP 1.0 0.0 0.0 GO:0014070 5 response to organic cyclic compound 433 471 24 23 21 20 18 18 51 453 2025 0.9598 0.072207 0.11454 3.82 24825;78968;24777;25044;362282;24587;24516;79438;24450;360504;316033;116663;29680;114851;58919;24770;25612;25649 tf;srebf1;slc10a1;sds;pck1;nefh;jun;igfals;hmgcs2;hba-a2;glb1;dusp6;cyp11a1;cdkn1a;ccnd1;ccl2;asns;apoa2 TF_10003;SREBF1_32750;SLC10A1_9832;SDS_9798;PCK1_9439;NEFH_33218;JUN_8938;IGFALS_8880;HMGCS2_8812;HBA2_32600;GLB1_8712;DUSP6_8506;CYP11A1_32785;CDKN1A_8271;CCND1_8224;CCL2_8218;ASNS_8091;APOA2_33095 52.67652722222223 56.15705 5.51457 27.52236995764799 55.68279445484209 23.741705422558468 35.898250000000004 38.492599999999996 1.34064 19.739433081809793 36.809651256963065 14.637714870760052 105.81244444444445 101.75955 11.4863 69.80070309577812 119.18382014217457 75.52806937028231 51.412;11.2357;7.96762;64.7394;5.51457;79.3182;57.7663;70.3663;30.5985;101.406;65.9159;45.5478;43.719;54.5478;28.2655;64.0097;85.6642;80.183 36.6131;4.94421;6.07525;43.4259;1.34064;39.4261;38.6865;46.0459;24.577;84.6435;47.8573;33.3115;33.4848;38.2987;22.3101;41.1311;53.6991;50.2978 86.0232;24.5771;11.4863;126.828;39.6721;264.141;109.049;148.796;40.5656;115.953;114.587;71.7388;63.9031;94.4701;38.3337;132.851;224.488;197.161 10 8 10 24825;78968;362282;24450;360504;316033;29680;58919;25612;25649 TF_10003;SREBF1_32750;PCK1_9439;HMGCS2_8812;HBA2_32600;GLB1_8712;CYP11A1_32785;CCND1_8224;ASNS_8091;APOA2_33095 50.391437 47.5655 32.40230609844375 35.976755000000004 35.048950000000005 24.753898053715023 94.52637999999999 74.96315 69.33556297190258 51.412;11.2357;5.51457;30.5985;101.406;65.9159;43.719;28.2655;85.6642;80.183 36.6131;4.94421;1.34064;24.577;84.6435;47.8573;33.4848;22.3101;53.6991;50.2978 86.0232;24.5771;39.6721;40.5656;115.953;114.587;63.9031;38.3337;224.488;197.161 8 24777;25044;24587;24516;79438;116663;114851;24770 SLC10A1_9832;SDS_9798;NEFH_33218;JUN_8938;IGFALS_8880;DUSP6_8506;CDKN1A_8271;CCL2_8218 55.53289 60.888 21.746929547467488 35.80011875 39.0563 12.587016125922824 119.92002500000001 117.9385 72.40128533008136 7.96762;64.7394;79.3182;57.7663;70.3663;45.5478;54.5478;64.0097 6.07525;43.4259;39.4261;38.6865;46.0459;33.3115;38.2987;41.1311 11.4863;126.828;264.141;109.049;148.796;71.7388;94.4701;132.851 0 Exp 2,7(0.39);Hill,2(0.12);Linear,7(0.39);Poly 2,2(0.12) 1.952432284312505 36.067938923835754 1.5230457782745361 3.3687045574188232 0.503187032834318 1.8480374813079834 39.96184099372206 65.39121345072239 26.77909716723516 45.017402832764844 73.56616479057695 138.05872409831196 CONFLICT 0.5555555555555556 0.4444444444444444 0.0 GO:0006511 8 ubiquitin-dependent protein catabolic process 65 67 2 2 2 2 2 2 67 65 2413 0.72807 0.54809 0.70303 2.99 85430;29657 herpud1;arntl HERPUD1_8795;ARNTL_8086 46.055350000000004 46.055350000000004 38.2177 11.084110927133473 43.3590045599459 10.407543301894014 32.5374 32.5374 27.1236 7.656269383975487 30.67491890638586 7.188935194579203 77.9294 77.9294 63.2034 20.825708919506233 72.86329179789394 19.554519870585114 53.893;38.2177 37.9512;27.1236 92.6554;63.2034 1 1 1 85430 HERPUD1_8795 53.893 53.893 37.9512 37.9512 92.6554 92.6554 53.893 37.9512 92.6554 1 29657 ARNTL_8086 38.2177 38.2177 27.1236 27.1236 63.2034 63.2034 38.2177 27.1236 63.2034 0 Linear,1(0.5);Power,1(0.5) 2.7346477461020613 6.424188733100891 1.5270863771438599 4.897102355957031 2.382961151325814 3.2120943665504456 30.693556000000005 61.41714400000001 21.926351999999998 43.148448 49.06644000000001 106.79236 CONFLICT 0.5 0.5 0.0 GO:0006650 6 glycerophospholipid metabolic process 42 46 3 3 3 3 3 3 66 43 2435 0.96576 0.12673 0.12673 6.52 29692;25649;81639 pla2g2a;apoa2;alox15 PLA2G2A_32641;APOA2_33095;ALOX15_8036 61.93566666666705 80.183 1.16694E-12 55.12559500207922 77.66846517165023 42.153591315886665 44.709333333333724 50.2978 1.16694E-12 42.19358751958976 55.19038110741989 33.872318567941285 108.86700000000037 129.44 1.16694E-12 100.17759842898948 143.01483361018845 82.30860522686781 1.5 92.90350000000001 1.16694E-12;80.183;105.624 1.16694E-12;50.2978;83.8302 1.16694E-12;197.161;129.44 2 1 2 25649;81639 APOA2_33095;ALOX15_8036 92.90350000000001 92.90350000000001 17.989503620166875 67.06400000000001 67.06400000000001 23.710987429459763 163.3005 163.3005 47.8859783287342 80.183;105.624 50.2978;83.8302 197.161;129.44 1 29692 PLA2G2A_32641 1.16694E-12 1.16694E-12 1.16694E-12 1.16694E-12 1.16694E-12 1.16694E-12 1.16694E-12 1.16694E-12 1.16694E-12 0 Hill,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 1.8785972692343549 5.651082873344421 1.6914535760879517 1.988358974456787 0.16670445371792547 1.9712703227996826 -0.44481647616284903 124.31614980949695 -3.0372057271882014 92.45587239385566 -4.494624302704338 222.2286243027051 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0048583 4 regulation of response to stimulus 781 832 33 33 27 28 24 24 45 808 1670 0.69859 0.39624 0.6978 2.88 29142;24825;84386;287877;29692;360918;338475;316351;314654;24516;85430;24440;24367;116663;299691;84032;114851;24770;287562;289054;29657;25649;29339;81639 vnn1;tf;slpi;pycr1;pla2g2a;pf4;nrep;npas2;myo1f;jun;herpud1;hbb;fgg;dusp6;cry1;col3a1;cdkn1a;ccl2;ccl12;aspm;arntl;apoa2;apcs;alox15 VNN1_10157;TF_10003;SLPI_9890;PYCR1_9631;PLA2G2A_32641;PF4_32963;NREP_9364;NPAS2_9350;MYO1F_32715;JUN_8938;HERPUD1_8795;HBB_8782;FGG_8639;DUSP6_8506;CRY1_8386;COL3A1_8354;CDKN1A_8271;CCL2_8218;CCL12_8217;ASPM_8092;ARNTL_8086;APOA2_33095;APCS_8057;ALOX15_8036 58.07167916666671 55.615750000000006 1.16694E-12 29.56371732015551 57.83866450531747 27.04672129814183 37.84067916666672 38.34215 1.16694E-12 18.446734298844106 38.172272263132484 18.056008874184307 129.41430833333342 99.76995 1.16694E-12 103.2312695367601 140.9839488043829 107.83220300919285 20.8684;51.412;56.5193;54.7122;1.16694E-12;105.82;36.861;58.2312;91.9576;57.7663;53.893;91.4283;93.1824;45.5478;37.2548;57.8774;54.5478;64.0097;25.5289;10.3235;38.2177;80.183;101.954;105.624 17.1194;36.6131;39.3315;38.3856;1.16694E-12;53.8521;28.0333;35.795;61.1322;38.6865;37.9512;54.7263;51.338;33.3115;21.8798;39.4215;38.2987;41.1311;13.9582;7.4611;27.1236;50.2978;58.4986;83.8302 26.5474;86.0232;100.108;94.9303;1.16694E-12;109.875;53.5645;99.4319;110.707;109.049;92.6554;277.036;327.378;71.7388;73.8251;106.603;94.4701;132.851;336.862;16.8623;63.2034;197.161;395.621;129.44 8 16 8 29142;24825;287877;314654;85430;289054;25649;81639 VNN1_10157;TF_10003;PYCR1_9631;MYO1F_32715;HERPUD1_8795;ASPM_8092;APOA2_33095;ALOX15_8036 58.6217125 54.3026 33.021725411243054 41.598825 38.1684 24.06487628015748 94.29082500000001 93.79285 57.00001690487842 20.8684;51.412;54.7122;91.9576;53.893;10.3235;80.183;105.624 17.1194;36.6131;38.3856;61.1322;37.9512;7.4611;50.2978;83.8302 26.5474;86.0232;94.9303;110.707;92.6554;16.8623;197.161;129.44 16 84386;29692;360918;338475;316351;24516;24440;24367;116663;299691;84032;114851;24770;287562;29657;29339 SLPI_9890;PLA2G2A_32641;PF4_32963;NREP_9364;NPAS2_9350;JUN_8938;HBB_8782;FGG_8639;DUSP6_8506;CRY1_8386;COL3A1_8354;CDKN1A_8271;CCL2_8218;CCL12_8217;ARNTL_8086;APCS_8057 57.79666250000007 57.1428 28.827807058599245 35.961606250000074 38.492599999999996 15.498761952296466 146.97605000000007 103.3555 117.63136281514937 56.5193;1.16694E-12;105.82;36.861;58.2312;57.7663;91.4283;93.1824;45.5478;37.2548;57.8774;54.5478;64.0097;25.5289;38.2177;101.954 39.3315;1.16694E-12;53.8521;28.0333;35.795;38.6865;54.7263;51.338;33.3115;21.8798;39.4215;38.2987;41.1311;13.9582;27.1236;58.4986 100.108;1.16694E-12;109.875;53.5645;99.4319;109.049;277.036;327.378;71.7388;73.8251;106.603;94.4701;132.851;336.862;63.2034;395.621 0 Exp 2,6(0.25);Exp 3,1(0.05);Hill,1(0.05);Linear,10(0.42);Poly 2,4(0.17);Power,2(0.09) 1.8795950958082737 47.99173295497894 1.5230457782745361 4.897102355957031 0.9145604357433236 1.6623327136039734 46.24372885207054 69.89962948126289 30.460448379365374 45.22090995396805 88.11319880875274 170.71541785791405 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0045071 7 negative regulation of viral genome replication 17 18 3 3 3 3 3 3 66 15 2463 0.99887 0.011601 0.011601 16.67 84386;286918;287562 slpi;mx2;ccl12 SLPI_9890;MX2_9268;CCL12_8217 37.902899999999995 31.6605 25.5289 16.41118190015577 36.92183810220073 16.03602094474553 25.62953333333333 23.5989 13.9582 12.807954248174577 24.857472522775836 12.619928259187773 161.252 100.108 46.786 154.40195269490602 167.10547879878533 157.95624457257114 0.0 25.5289 0.5 28.5947 56.5193;31.6605;25.5289 39.3315;23.5989;13.9582 100.108;46.786;336.862 0 3 0 3 84386;286918;287562 SLPI_9890;MX2_9268;CCL12_8217 37.902899999999995 31.6605 16.41118190015577 25.62953333333333 23.5989 12.807954248174577 161.252 100.108 154.40195269490602 56.5193;31.6605;25.5289 39.3315;23.5989;13.9582 100.108;46.786;336.862 0 Exp 2,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 1.8602596971546999 5.770331859588623 1.5314651727676392 2.6565301418304443 0.635380589963735 1.5823365449905396 19.33189943596131 56.47390056403869 11.135968700747405 40.123097965919264 -13.470257545543433 335.9742575455434 DOWN 0.0 1.0 0.0 GO:0035519 11 protein K29-linked ubiquitination 1 1 1 1 1 1 1 1 68 0 2478 1.0 0.027091 0.027091 100.0 360847 ube2t UBE2T_10125 10.9914 10.9914 10.9914 10.9914 7.86591 7.86591 7.86591 7.86591 18.2059 18.2059 18.2059 18.2059 0.0 10.9914 0.0 10.9914 10.9914 7.86591 18.2059 1 0 1 360847 UBE2T_10125 10.9914 10.9914 7.86591 7.86591 18.2059 18.2059 10.9914 7.86591 18.2059 0 0 Poly 2,1(1) 2.363434076309204 2.363434076309204 2.363434076309204 2.363434076309204 0.0 2.363434076309204 10.9914 10.9914 7.86591 7.86591 18.2059 18.2059 UP 1.0 0.0 0.0 GO:0044314 11 protein K27-linked ubiquitination 1 1 1 1 1 1 1 1 68 0 2478 1.0 0.027091 0.027091 100.0 360847 ube2t UBE2T_10125 10.9914 10.9914 10.9914 10.9914 7.86591 7.86591 7.86591 7.86591 18.2059 18.2059 18.2059 18.2059 0.0 10.9914 0.0 10.9914 10.9914 7.86591 18.2059 1 0 1 360847 UBE2T_10125 10.9914 10.9914 7.86591 7.86591 18.2059 18.2059 10.9914 7.86591 18.2059 0 0 Poly 2,1(1) 2.363434076309204 2.363434076309204 2.363434076309204 2.363434076309204 0.0 2.363434076309204 10.9914 10.9914 7.86591 7.86591 18.2059 18.2059 UP 1.0 0.0 0.0 GO:0098542 4 defense response to other organism 155 169 8 8 8 8 8 8 61 161 2317 0.96382 0.083153 0.13273 4.73 29142;84386;29692;360918;314654;286918;170568;29339 vnn1;slpi;pla2g2a;pf4;myo1f;mx2;dmbt1;apcs VNN1_10157;SLPI_9890;PLA2G2A_32641;PF4_32963;MYO1F_32715;MX2_9268;DMBT1_32993;APCS_8057 53.815400000000146 44.0899 1.16694E-12 41.378042126125415 55.10673705241953 37.01109968007825 33.27355000000015 31.4652 1.16694E-12 23.17438021578361 34.92710222899421 20.827924273685134 118.76617500000015 104.9915 1.16694E-12 123.445787785405 142.9763584527292 139.00871407721206 20.8684;56.5193;1.16694E-12;105.82;91.9576;31.6605;21.7434;101.954 17.1194;39.3315;1.16694E-12;53.8521;61.1322;23.5989;12.6557;58.4986 26.5474;100.108;1.16694E-12;109.875;110.707;46.786;160.485;395.621 3 5 3 29142;314654;170568 VNN1_10157;MYO1F_32715;DMBT1_32993 44.85646666666667 21.7434 40.793124141371344 30.30243333333333 17.1194 26.79248101545159 99.24646666666668 110.707 67.70028095697485 20.8684;91.9576;21.7434 17.1194;61.1322;12.6557 26.5474;110.707;160.485 5 84386;29692;360918;286918;29339 SLPI_9890;PLA2G2A_32641;PF4_32963;MX2_9268;APCS_8057 59.190760000000225 56.5193 45.474109946902374 35.05622000000024 39.3315 23.881567402433603 130.47800000000024 100.108 154.65808280364763 56.5193;1.16694E-12;105.82;31.6605;101.954 39.3315;1.16694E-12;53.8521;23.5989;58.4986 100.108;1.16694E-12;109.875;46.786;395.621 0 Exp 2,2(0.25);Exp 3,1(0.13);Hill,1(0.13);Linear,2(0.25);Poly 2,2(0.25) 1.896736694485352 15.51999831199646 1.5823365449905396 2.6565301418304443 0.46092661395327483 1.7321658730506897 25.141879703986348 82.48892029601394 17.21452382763171 49.33257617236859 33.22260842106431 204.30974157893598 DOWN 0.375 0.625 0.0 GO:0030258 5 lipid modification 64 70 4 4 4 4 4 4 65 66 2412 0.96086 0.11936 0.11936 5.71 171142;29740;25086;81639 ehhadh;eci1;cyp2e1;alox15 EHHADH_8534;ECI1_8520;CYP2E1_8421;ALOX15_8036 72.775875 76.39195 32.6956 37.203265836516266 81.94072447262681 35.873472668672115 46.6173 38.4977 25.6436 27.20932821968721 55.65430234178805 29.363012580498218 88.33397500000001 89.42085 45.0542 37.418962045677205 98.87275313912608 37.756520673663864 2.5 104.4275 32.6956;103.231;49.5529;105.624 25.6436;49.9975;26.9979;83.8302 45.0542;107.244;71.5977;129.44 4 0 4 171142;29740;25086;81639 EHHADH_8534;ECI1_8520;CYP2E1_8421;ALOX15_8036 72.775875 76.39195 37.203265836516266 46.6173 38.4977 27.20932821968721 88.33397500000001 89.42085 37.418962045677205 32.6956;103.231;49.5529;105.624 25.6436;49.9975;26.9979;83.8302 45.0542;107.244;71.5977;129.44 0 0 Exp 2,1(0.25);Exp 3,1(0.25);Poly 2,2(0.5) 1.8190854422752314 7.328673601150513 1.618504285812378 2.2035675048828125 0.2605634897077847 1.7533009052276611 36.31667448021404 109.23507551978597 19.952158344706532 73.28244165529347 51.66339219523633 125.00455780476369 UP 1.0 0.0 0.0 GO:1903900 6 regulation of viral life cycle 36 38 5 5 5 5 5 5 64 33 2445 0.99956 0.0031605 0.0031605 13.16 360243;84386;286918;287562;29339 top2a;slpi;mx2;ccl12;apcs TOP2A_10059;SLPI_9890;MX2_9268;CCL12_8217;APCS_8057 45.90036 31.6605 13.8391 35.00166721783406 49.728509386560646 33.45135959662787 28.940688 23.5989 9.31624 20.123169114424293 31.30512804704323 19.07693737752954 181.41444 100.108 27.6952 172.05635199366515 209.23686333167691 168.17375866927517 0.5 19.684 2.5 44.0899 13.8391;56.5193;31.6605;25.5289;101.954 9.31624;39.3315;23.5989;13.9582;58.4986 27.6952;100.108;46.786;336.862;395.621 1 4 1 360243 TOP2A_10059 13.8391 13.8391 9.31624 9.31624 27.6952 27.6952 13.8391 9.31624 27.6952 4 84386;286918;287562;29339 SLPI_9890;MX2_9268;CCL12_8217;APCS_8057 53.91567499999999 44.0899 34.71580495551222 33.8468 31.4652 19.479639299364177 219.84425 218.485 172.12064287658822 56.5193;31.6605;25.5289;101.954 39.3315;23.5989;13.9582;58.4986 100.108;46.786;336.862;395.621 0 Exp 2,1(0.2);Linear,2(0.4);Poly 2,2(0.4) 1.817110756141426 9.289210557937622 1.5314651727676392 2.6565301418304443 0.46800503204610633 1.6244933605194092 15.220045967838065 76.58067403216194 11.301952567469826 46.57942343253017 30.60039798476106 332.22848201523897 DOWN 0.2 0.8 0.0 GO:0006898 6 receptor-mediated endocytosis 38 39 2 2 2 2 2 2 67 37 2441 0.913 0.28537 0.28537 5.13 286918;170568 mx2;dmbt1 MX2_9268;DMBT1_32993 26.70195 26.70195 21.7434 7.012448659705119 28.05757239418825 6.74529554977026 18.127299999999998 18.127299999999998 12.6557 7.738010927880638 19.62318558994876 7.443216087389069 103.63550000000001 103.63550000000001 46.786 80.39733391412929 88.09336463816943 77.33443836538206 0.5 26.70195 31.6605;21.7434 23.5989;12.6557 46.786;160.485 1 1 1 170568 DMBT1_32993 21.7434 21.7434 12.6557 12.6557 160.485 160.485 21.7434 12.6557 160.485 1 286918 MX2_9268 31.6605 31.6605 23.5989 23.5989 46.786 46.786 31.6605 23.5989 46.786 0 Exp 2,1(0.5);Poly 2,1(0.5) 2.0615540862779143 4.256363391876221 1.5998332500457764 2.6565301418304443 0.7471975378396861 2.1281816959381104 16.983192000000003 36.420708 7.402963999999997 28.851636 -7.789519999999996 215.06052 CONFLICT 0.5 0.5 0.0 GO:0045069 7 regulation of viral genome replication 22 24 4 4 4 4 4 4 65 20 2458 0.99964 0.0034817 0.0034817 16.67 360243;84386;286918;287562 top2a;slpi;mx2;ccl12 TOP2A_10059;SLPI_9890;MX2_9268;CCL12_8217 31.886950000000002 28.5947 13.8391 18.008827794075508 35.475516692437445 15.999472151156095 21.551209999999998 18.77855 9.31624 13.262478885703583 23.8836878169806 12.313022145866004 127.86280000000001 73.447 27.6952 142.66276098043244 158.37029018836103 149.3662195810718 0.5 19.684 1.5 28.5947 13.8391;56.5193;31.6605;25.5289 9.31624;39.3315;23.5989;13.9582 27.6952;100.108;46.786;336.862 1 3 1 360243 TOP2A_10059 13.8391 13.8391 9.31624 9.31624 27.6952 27.6952 13.8391 9.31624 27.6952 3 84386;286918;287562 SLPI_9890;MX2_9268;CCL12_8217 37.902899999999995 31.6605 16.41118190015577 25.62953333333333 23.5989 12.807954248174577 161.252 100.108 154.40195269490602 56.5193;31.6605;25.5289 39.3315;23.5989;13.9582 100.108;46.786;336.862 0 Exp 2,1(0.25);Linear,1(0.25);Poly 2,2(0.5) 1.8687330381908103 7.664717197418213 1.5314651727676392 2.6565301418304443 0.5189894958958214 1.7383609414100647 14.238298761806 49.535601238194005 8.553980692010487 34.54843930798951 -11.94670576082379 267.67230576082386 DOWN 0.25 0.75 0.0 GO:0050796 7 regulation of insulin secretion 45 50 2 2 2 2 2 2 67 48 2430 0.84811 0.39522 0.39522 4.0 78968;29657 srebf1;arntl SREBF1_32750;ARNTL_8086 24.7267 24.7267 11.2357 19.07915516997542 32.255611748236085 15.831776204031742 16.033905 16.033905 4.94421 15.683197071581098 22.22272235748684 13.013829175818657 43.89025 43.89025 24.5771 27.31291866214594 54.66832441482809 22.664107078414883 11.2357;38.2177 4.94421;27.1236 24.5771;63.2034 1 1 1 78968 SREBF1_32750 11.2357 11.2357 4.94421 4.94421 24.5771 24.5771 11.2357 4.94421 24.5771 1 29657 ARNTL_8086 38.2177 38.2177 27.1236 27.1236 63.2034 63.2034 38.2177 27.1236 63.2034 0 Hill,1(0.5);Power,1(0.5) 3.740731976555364 7.75452184677124 2.857419490814209 4.897102355957031 1.442273585412496 3.87726092338562 -1.7156599999999962 51.16906 -5.701897199999998 37.76970719999999 6.0364760000000075 81.744024 CONFLICT 0.5 0.5 0.0 GO:0071300 6 cellular response to retinoic acid 19 22 2 2 2 2 2 2 67 20 2458 0.97973 0.1181 0.1181 9.09 362282;24770 pck1;ccl2 PCK1_9439;CCL2_8218 34.762135 34.762135 5.51457 41.36230308938865 44.749108414634144 38.8762246223734 21.235870000000002 21.235870000000002 1.34064 28.136104092532076 28.029363170731713 26.444985433617532 86.26155 86.26155 39.6721 65.88743205350322 102.17014268292684 61.927272346700825 0.5 34.762135 5.51457;64.0097 1.34064;41.1311 39.6721;132.851 1 1 1 362282 PCK1_9439 5.51457 5.51457 1.34064 1.34064 39.6721 39.6721 5.51457 1.34064 39.6721 1 24770 CCL2_8218 64.0097 64.0097 41.1311 41.1311 132.851 132.851 64.0097 41.1311 132.851 0 Exp 2,1(0.5);Hill,1(0.5) 1.9125797803419218 3.9048653841018677 1.559963583946228 2.3449018001556396 0.5550351354941474 1.9524326920509338 -22.563092399999988 92.08736239999999 -17.7587808 60.23052080000001 -5.053771999999981 177.57687199999998 CONFLICT 0.5 0.5 0.0 GO:0010165 6 response to X-ray 13 13 2 2 2 2 2 2 67 11 2467 0.99552 0.046539 0.046539 15.38 114851;58919 cdkn1a;ccnd1 CDKN1A_8271;CCND1_8224 41.40665 41.40665 28.2655 18.584392555179218 43.534281825618656 18.339193337609725 30.304399999999998 30.304399999999998 22.3101 11.305647481679225 31.598725618651578 11.15648275066135 66.4019 66.4019 38.3337 39.69442911140052 70.94631168450475 39.17070777205169 0.0 28.2655 0.5 41.40665 54.5478;28.2655 38.2987;22.3101 94.4701;38.3337 1 1 1 58919 CCND1_8224 28.2655 28.2655 22.3101 22.3101 38.3337 38.3337 28.2655 22.3101 38.3337 1 114851 CDKN1A_8271 54.5478 54.5478 38.2987 38.2987 94.4701 94.4701 54.5478 38.2987 94.4701 0 Linear,2(1) 1.9427984172553292 3.9321112632751465 1.6645443439483643 2.2675669193267822 0.42640135225865533 1.9660556316375732 15.649995999999998 67.163304 14.635572000000002 45.97322799999999 11.388228000000005 121.415572 CONFLICT 0.5 0.5 0.0 GO:1901568 4 fatty acid derivative metabolic process 46 57 6 6 6 5 5 5 64 52 2426 0.99613 0.017729 0.017729 8.77 24450;24306;25086;499353;81639 hmgcs2;cyp4a2;cyp2e1;cyp2c24;alox15 HMGCS2_8812;CYP4A2_8425;CYP2E1_8421;CYP2C24_32875;ALOX15_8036 51.18152 49.5529 10.5651 35.74321008781947 54.003624982726635 37.57578572981039 37.291778 26.9979 7.63639 28.94140420071079 40.60948963925961 30.267867119468725 71.64824 71.5977 17.0471 44.911278472706606 75.24514220517109 46.90997217012133 1.5 40.0757 30.5985;59.5671;49.5529;10.5651;105.624 24.577;43.4174;26.9979;7.63639;83.8302 40.5656;99.5908;71.5977;17.0471;129.44 4 1 4 24450;24306;25086;81639 HMGCS2_8812;CYP4A2_8425;CYP2E1_8421;ALOX15_8036 61.335625 54.56 31.87575516756427 44.705625 35.20765 27.392924643950803 85.298525 85.59425 38.04158305761168 30.5985;59.5671;49.5529;105.624 24.577;43.4174;26.9979;83.8302 40.5656;99.5908;71.5977;129.44 1 499353 CYP2C24_32875 10.5651 10.5651 7.63639 7.63639 17.0471 17.0471 10.5651 7.63639 17.0471 0 Exp 2,2(0.4);Poly 2,3(0.6) 2.229448811405922 11.469416856765747 1.6914535760879517 3.3687045574188232 0.6461085045875593 2.2035675048828125 19.851214983755142 82.51182501624487 11.923518714421785 62.66003728557821 32.28176872441322 111.01471127558682 UP 0.8 0.2 0.0 GO:0071495 4 cellular response to endogenous stimulus 313 332 13 13 12 12 11 11 58 321 2157 0.82055 0.28253 0.4673 3.31 24825;78968;362282;24587;24516;79438;24450;29680;84032;24770;25612 tf;srebf1;pck1;nefh;jun;igfals;hmgcs2;cyp11a1;col3a1;ccl2;asns TF_10003;SREBF1_32750;PCK1_9439;NEFH_33218;JUN_8938;IGFALS_8880;HMGCS2_8812;CYP11A1_32785;COL3A1_8354;CCL2_8218;ASNS_8091 50.68017 57.7663 5.51457 25.998686754559362 58.21399700856238 23.215522991628156 32.66999545454546 38.6865 1.34064 16.285302230304087 36.730701568869826 12.98381972751436 112.7881 106.603 24.5771 76.54097969605562 136.56875944445693 84.06813935786354 51.412;11.2357;5.51457;79.3182;57.7663;70.3663;30.5985;43.719;57.8774;64.0097;85.6642 36.6131;4.94421;1.34064;39.4261;38.6865;46.0459;24.577;33.4848;39.4215;41.1311;53.6991 86.0232;24.5771;39.6721;264.141;109.049;148.796;40.5656;63.9031;106.603;132.851;224.488 6 5 6 24825;78968;362282;24450;29680;25612 TF_10003;SREBF1_32750;PCK1_9439;HMGCS2_8812;CYP11A1_32785;ASNS_8091 38.023995 37.15875 29.36281434435313 25.776475000000005 29.030900000000003 19.945203634157007 79.87151666666666 52.234350000000006 74.06103090050574 51.412;11.2357;5.51457;30.5985;43.719;85.6642 36.6131;4.94421;1.34064;24.577;33.4848;53.6991 86.0232;24.5771;39.6721;40.5656;63.9031;224.488 5 24587;24516;79438;84032;24770 NEFH_33218;JUN_8938;IGFALS_8880;COL3A1_8354;CCL2_8218 65.86758 64.0097 9.138970021123882 40.94222 39.4261 2.9909324251812763 152.288 132.851 64.91882428849124 79.3182;57.7663;70.3663;57.8774;64.0097 39.4261;38.6865;46.0459;39.4215;41.1311 264.141;109.049;148.796;106.603;132.851 0 Exp 2,7(0.64);Hill,2(0.19);Linear,2(0.19) 1.917761926976627 21.891797184944153 1.5230457782745361 3.3687045574188232 0.6178908894744831 1.752767562866211 35.31592795877837 66.04441204122165 23.04599684480955 42.293994064281364 67.5552715412242 158.0209284587758 CONFLICT 0.5454545454545454 0.45454545454545453 0.0 GO:1901576 4 organic substance biosynthetic process 397 444 21 19 18 18 15 15 54 429 2049 0.8668 0.20964 0.33514 3.38 78968;25044;83792;287877;362282;114519;24516;24450;81660;24306;29680;299691;25612;25649;81639 srebf1;sds;scd2;pycr1;pck1;nfil3;jun;hmgcs2;gatm;cyp4a2;cyp11a1;cry1;asns;apoa2;alox15 SREBF1_32750;SDS_9798;SCD_9786;PYCR1_9631;PCK1_9439;NFIL3_9304;JUN_8938;HMGCS2_8812;GATM_32792;CYP4A2_8425;CYP11A1_32785;CRY1_8386;ASNS_8091;APOA2_33095;ALOX15_8036 52.74100466666667 54.7122 5.51457 28.302818440969265 57.64132728096385 25.51892859665963 36.386316666666666 38.3856 1.34064 20.582179964750942 39.85793414835065 18.66358747057964 102.16688 94.9303 24.5771 64.08599510113847 110.09995571979823 61.91885477353509 11.2357;64.7394;83.9984;54.7122;5.51457;33.1149;57.7663;30.5985;37.423;59.5671;43.719;37.2548;85.6642;80.183;105.624 4.94421;43.4259;54.1928;38.3856;1.34064;25.603;38.6865;24.577;28.03;43.4174;33.4848;21.8798;53.6991;50.2978;83.8302 24.5771;126.828;206.18;94.9303;39.6721;46.6318;109.049;40.5656;55.6613;99.5908;63.9031;73.8251;224.488;197.161;129.44 10 5 10 78968;83792;287877;362282;24450;24306;29680;25612;25649;81639 SREBF1_32750;SCD_9786;PYCR1_9631;PCK1_9439;HMGCS2_8812;CYP4A2_8425;CYP11A1_32785;ASNS_8091;APOA2_33095;ALOX15_8036 56.081667 57.13965 33.45682180145031 38.81695499999999 40.9015 24.54087808150912 112.05080000000001 97.26055 74.39801596601887 11.2357;83.9984;54.7122;5.51457;30.5985;59.5671;43.719;85.6642;80.183;105.624 4.94421;54.1928;38.3856;1.34064;24.577;43.4174;33.4848;53.6991;50.2978;83.8302 24.5771;206.18;94.9303;39.6721;40.5656;99.5908;63.9031;224.488;197.161;129.44 5 25044;114519;24516;81660;299691 SDS_9798;NFIL3_9304;JUN_8938;GATM_32792;CRY1_8386 46.05968 37.423 14.192096159376867 31.52504 28.03 9.127342097949427 82.39903999999999 73.8251 34.46689534659312 64.7394;33.1149;57.7663;37.423;37.2548 43.4259;25.603;38.6865;28.03;21.8798 126.828;46.6318;109.049;55.6613;73.8251 0 Exp 2,8(0.54);Hill,2(0.14);Linear,4(0.27);Poly 2,1(0.07) 2.03414868235596 31.353741884231567 1.5230457782745361 3.3687045574188232 0.5378045485062591 1.9150761365890503 38.41780232224614 67.0642070110872 25.970296476335747 46.802336856997584 69.7348917444263 134.59886825557368 UP 0.6666666666666666 0.3333333333333333 0.0 GO:2000145 5 regulation of cell motility 264 277 11 11 8 7 6 6 63 271 2207 0.36291 0.77838 0.69609 2.17 24825;314654;24516;84032;24770;287562 tf;myo1f;jun;col3a1;ccl2;ccl12 TF_10003;MYO1F_32715;JUN_8938;COL3A1_8354;CCL2_8218;CCL12_8217 58.09198333333333 57.82185 25.5289 21.38704304904412 50.633137785934075 24.222791765829754 38.490433333333335 39.054 13.9582 15.005884834113118 32.92569246654061 17.47477944699694 147.01586666666665 109.878 86.0232 94.18632568662328 189.01386897267642 121.00955484153644 51.412;91.9576;57.7663;57.8774;64.0097;25.5289 36.6131;61.1322;38.6865;39.4215;41.1311;13.9582 86.0232;110.707;109.049;106.603;132.851;336.862 2 4 2 24825;314654 TF_10003;MYO1F_32715 71.6848 71.6848 28.670068707277284 48.87265 48.87265 17.337621878591072 98.3651 98.3651 17.454082365452518 51.412;91.9576 36.6131;61.1322 86.0232;110.707 4 24516;84032;24770;287562 JUN_8938;COL3A1_8354;CCL2_8218;CCL12_8217 51.295575 57.82185 17.42375024143289 33.299325 39.054 12.934688465872174 171.34125 120.95 110.98045390780908 57.7663;57.8774;64.0097;25.5289 38.6865;39.4215;41.1311;13.9582 109.049;106.603;132.851;336.862 0 Exp 2,3(0.5);Linear,1(0.17);Poly 2,2(0.34) 1.6247269333736711 9.795206069946289 1.5230457782745361 2.0048909187316895 0.1844474614662026 1.5731634497642517 40.97878475814869 75.20518190851799 26.483224745701705 50.49764192096495 71.651110031259 222.38062330207435 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0070141 7 response to UV-A 3 3 1 1 1 1 1 1 68 2 2476 0.99787 0.07912 0.07912 33.33 58919 ccnd1 CCND1_8224 28.2655 28.2655 28.2655 28.265500000000003 22.3101 22.3101 22.3101 22.3101 38.3337 38.3337 38.3337 38.3337 0.0 28.2655 0.0 28.2655 28.2655 22.3101 38.3337 1 0 1 58919 CCND1_8224 28.2655 28.2655 22.3101 22.3101 38.3337 38.3337 28.2655 22.3101 38.3337 0 0 Linear,1(1) 2.2675669193267822 2.2675669193267822 2.2675669193267822 2.2675669193267822 0.0 2.2675669193267822 28.2655 28.2655 22.3101 22.3101 38.3337 38.3337 UP 1.0 0.0 0.0 GO:0043065 8 positive regulation of apoptotic process 196 210 8 8 7 5 5 5 64 205 2273 0.49038 0.6853 1.0 2.38 360243;24516;361921;116663;24770 top2a;jun;ect2;dusp6;ccl2 TOP2A_10059;JUN_8938;ECT2_8523;DUSP6_8506;CCL2_8218 39.11542000000001 45.5478 13.8391 23.759201565856532 42.81390880273222 20.601857093475278 26.407538 33.3115 9.31624 15.73279927303848 29.383962235797778 13.782395364500243 74.28186000000001 71.7388 27.6952 46.82441183632742 78.26727255760258 40.35470507704628 13.8391;57.7663;14.4142;45.5478;64.0097 9.31624;38.6865;9.59235;33.3115;41.1311 27.6952;109.049;30.0753;71.7388;132.851 2 3 2 360243;361921 TOP2A_10059;ECT2_8523 14.12665 14.12665 0.40665710986038317 9.454295 9.454295 0.19523925335338116 28.88525 28.88525 1.6829848499020597 13.8391;14.4142 9.31624;9.59235 27.6952;30.0753 3 24516;116663;24770 JUN_8938;DUSP6_8506;CCL2_8218 55.7746 57.7663 9.390718266991085 37.709700000000005 38.6865 4.000267456058443 104.54626666666667 109.049 30.803915381219518 57.7663;45.5478;64.0097 38.6865;33.3115;41.1311 109.049;71.7388;132.851 0 Exp 2,2(0.4);Linear,1(0.2);Poly 2,2(0.4) 1.6587532395589002 8.32481563091278 1.5230457782745361 1.8943853378295898 0.16313425235179305 1.5676488876342773 18.28956160138913 59.94127839861087 12.617131408857661 40.19794459114234 33.238453393990234 115.32526660600976 DOWN 0.4 0.6 0.0 GO:0017085 5 response to insecticide 12 12 2 2 2 2 2 2 67 10 2468 0.99649 0.040069 0.040069 16.67 24587;29680 nefh;cyp11a1 NEFH_33218;CYP11A1_32785 61.518600000000006 61.518600000000006 43.719 25.172435724816154 72.30860652856246 20.020065897672808 36.45545 36.45545 33.4848 4.201133519063618 38.25623950617284 3.3412328793299304 164.02205 164.02205 63.9031 141.58957694055377 224.7135331868592 112.60859663171087 0.0 43.719 0.5 61.518600000000006 79.3182;43.719 39.4261;33.4848 264.141;63.9031 1 1 1 29680 CYP11A1_32785 43.719 43.719 33.4848 33.4848 63.9031 63.9031 43.719 33.4848 63.9031 1 24587 NEFH_33218 79.3182 79.3182 39.4261 39.4261 264.141 264.141 79.3182 39.4261 264.141 0 Exp 2,2(1) 1.7599213167873746 3.5198718309402466 1.752767562866211 1.7671042680740356 0.010137581472325342 1.7599359154701233 26.631384000000004 96.40581600000002 30.632976 42.277924 -32.21109200000001 360.255192 CONFLICT 0.5 0.5 0.0 GO:0019373 7 epoxygenase P450 pathway 10 13 2 2 2 2 2 2 67 11 2467 0.99552 0.046539 0.046539 15.38 25086;499353 cyp2e1;cyp2c24 CYP2E1_8421;CYP2C24_32875 30.059 30.059 10.5651 27.568537763544875 24.180359168890583 26.28511819219435 17.317145 17.317145 7.63639 13.69065501501115 14.39778655356462 13.053303308454263 44.3224 44.3224 17.0471 38.57309917779488 36.097176096073206 36.777375703556416 0.0 10.5651 0.5 30.059 49.5529;10.5651 26.9979;7.63639 71.5977;17.0471 1 1 1 25086 CYP2E1_8421 49.5529 49.5529 26.9979 26.9979 71.5977 71.5977 49.5529 26.9979 71.5977 1 499353 CYP2C24_32875 10.5651 10.5651 7.63639 7.63639 17.0471 17.0471 10.5651 7.63639 17.0471 0 Poly 2,2(1) 2.2466697488550826 4.494182586669922 2.2035675048828125 2.2906150817871094 0.06155193191488582 2.247091293334961 -8.149043999999993 68.267044 -1.657134799999998 36.2914248 -9.137188000000002 97.78198800000001 CONFLICT 0.5 0.5 0.0 GO:0051128 5 regulation of cellular component organization 515 547 12 12 11 12 11 11 58 536 1942 0.16197 0.90408 0.2997 2.01 360243;24825;78968;291441;314654;361921;306575;114851;282840;25649;81639 top2a;tf;srebf1;ska1;myo1f;ect2;ckap2;cdkn1a;atf5;apoa2;alox15 TOP2A_10059;TF_10003;SREBF1_32750;SKA1_9829;MYO1F_32715;ECT2_8523;CKAP2_8324;CDKN1A_8271;ATF5_8097;APOA2_33095;ALOX15_8036 49.564736363636364 51.412 11.2357 38.79086432017913 64.67312534637797 35.33895893605887 35.095968181818186 36.6131 4.94421 29.24787690936346 46.244680718034815 27.382197097528753 77.94377272727273 86.0232 21.0483 58.08265104159918 103.67724462969397 57.96067480931585 13.8391;51.412;11.2357;11.9206;91.9576;14.4142;12.1218;54.5478;97.9563;80.183;105.624 9.31624;36.6131;4.94421;8.34831;61.1322;9.59235;8.47044;38.2987;75.2121;50.2978;83.8302 27.6952;86.0232;24.5771;21.0483;110.707;30.0753;21.3803;94.4701;114.804;197.161;129.44 9 2 9 360243;24825;78968;291441;314654;361921;306575;25649;81639 TOP2A_10059;TF_10003;SREBF1_32750;SKA1_9829;MYO1F_32715;ECT2_8523;CKAP2_8324;APOA2_33095;ALOX15_8036 43.63422222222222 14.4142 39.31316288925307 30.28276111111111 9.59235 28.996376612324966 72.01193333333333 30.0753 63.035175899175535 13.8391;51.412;11.2357;11.9206;91.9576;14.4142;12.1218;80.183;105.624 9.31624;36.6131;4.94421;8.34831;61.1322;9.59235;8.47044;50.2978;83.8302 27.6952;86.0232;24.5771;21.0483;110.707;30.0753;21.3803;197.161;129.44 2 114851;282840 CDKN1A_8271;ATF5_8097 76.25205 76.25205 30.694444711136256 56.7554 56.7554 26.101715456651508 104.63705 104.63705 14.378238577969157 54.5478;97.9563 38.2987;75.2121 94.4701;114.804 0 Hill,1(0.1);Linear,3(0.28);Poly 2,7(0.64) 1.9576002320826031 21.845726132392883 1.5863633155822754 2.857419490814209 0.3721682879702027 1.8943853378295898 26.64080047295519 72.48867225431754 17.811577463563456 52.380358900072906 43.61911943137325 112.26842602317221 UP 0.8181818181818182 0.18181818181818182 0.0 GO:0048146 7 positive regulation of fibroblast proliferation 27 30 2 2 2 2 2 2 67 28 2450 0.95416 0.19436 0.19436 6.67 24516;114851 jun;cdkn1a JUN_8938;CDKN1A_8271 56.15705 56.15705 54.5478 2.2758231752491507 55.7917800230365 2.2164220746189107 38.492599999999996 38.492599999999996 38.2987 0.27421600974518423 38.44858828738031 0.26705871696073824 101.75955 101.75955 94.4701 10.308839052240765 100.10497971348356 10.039768769197256 0.5 56.15705 57.7663;54.5478 38.6865;38.2987 109.049;94.4701 0 2 0 2 24516;114851 JUN_8938;CDKN1A_8271 56.15705 56.15705 2.2758231752491507 38.492599999999996 38.492599999999996 0.27421600974518423 101.75955 101.75955 10.308839052240765 57.7663;54.5478 38.6865;38.2987 109.049;94.4701 0 Exp 2,1(0.5);Linear,1(0.5) 1.5922239904615536 3.1875901222229004 1.5230457782745361 1.6645443439483643 0.1000545953161339 1.5937950611114502 53.00292 59.31117999999999 38.11255599999999 38.872644 87.472228 116.04687200000001 DOWN 0.0 1.0 0.0 GO:0030330 7 DNA damage response, signal transduction by p53 class mediator 13 14 2 2 2 2 2 2 67 12 2466 0.99441 0.053364 0.053364 14.29 299923;114851 ndrg1;cdkn1a NDRG1_32364;CDKN1A_8271 77.10595 77.10595 54.5478 31.902041672046604 77.3403986355455 31.900318658589953 40.426649999999995 40.426649999999995 38.2987 3.0093757500519236 40.44876595250536 3.0092132151594875 99.93955 99.93955 94.4701 7.734970368721659 99.99639442605817 7.734552606806418 0.0 54.5478 0.5 77.10595 99.6641;54.5478 42.5546;38.2987 105.409;94.4701 0 2 0 2 299923;114851 NDRG1_32364;CDKN1A_8271 77.10595 77.10595 31.902041672046604 40.426649999999995 40.426649999999995 3.0093757500519236 99.93955 99.93955 7.734970368721659 99.6641;54.5478 42.5546;38.2987 105.409;94.4701 0 Exp 3,1(0.5);Linear,1(0.5) 1.5920140476765434 3.187188506126404 1.5226441621780396 1.6645443439483643 0.10033858078140032 1.593594253063202 32.89197600000001 121.31992400000001 36.25586799999999 44.597432 89.219428 110.659672 DOWN 0.0 1.0 0.0 GO:1902532 7 negative regulation of intracellular signal transduction 138 146 6 6 5 5 4 4 65 142 2336 0.63819 0.56583 1.0 2.74 29142;85430;116663;29657 vnn1;herpud1;dusp6;arntl VNN1_10157;HERPUD1_8795;DUSP6_8506;ARNTL_8086 39.631725 41.88275 20.8684 14.05282581057987 41.50443229013441 10.709999977748925 28.876424999999998 30.217550000000003 17.1194 9.005951067442407 30.02834574689323 7.041243773703299 63.536249999999995 67.4711 26.5474 27.589204027843973 67.02954804970834 20.60310220819531 20.8684;53.893;45.5478;38.2177 17.1194;37.9512;33.3115;27.1236 26.5474;92.6554;71.7388;63.2034 2 2 2 29142;85430 VNN1_10157;HERPUD1_8795 37.380700000000004 37.380700000000004 23.35191860597325 27.5353 27.5353 14.730307044321922 59.6014 59.6014 46.7454150906803 20.8684;53.893 17.1194;37.9512 26.5474;92.6554 2 116663;29657 DUSP6_8506;ARNTL_8086 41.88275 41.88275 5.183163416775496 30.217550000000003 30.217550000000003 4.375506051304219 67.4711 67.4711 6.035439220139542 45.5478;38.2177 33.3115;27.1236 71.7388;63.2034 0 Exp 2,1(0.25);Linear,2(0.5);Power,1(0.25) 2.3591531756261186 10.634081959724426 1.5270863771438599 4.897102355957031 1.5792041970842898 2.1049466133117676 25.859955705631727 53.40349429436828 20.05059295390646 37.702257046093536 36.49883005271293 90.57366994728706 CONFLICT 0.5 0.5 0.0 GO:0050794 4 regulation of cellular process 1555 1680 57 57 50 51 46 46 23 1634 844 0.59555 0.50648 1.0 2.74 29142;360243;24825;78968;84386;24777;291441;287877;29692;360918;362282;338475;316351;114519;24587;299923;314654;366960;290350;100911740;304477;303575;24516;85430;24440;360504;24367;361921;116663;170568;24309;299691;84032;498709;306575;114851;58919;24770;287562;282840;289054;25612;29657;25649;29339;81639 vnn1;top2a;tf;srebf1;slpi;slc10a1;ska1;pycr1;pla2g2a;pf4;pck1;nrep;npas2;nfil3;nefh;ndrg1;myo1f;maff;loxl2;mrln;kntc1;kif18b;jun;herpud1;hbb;hba-a2;fgg;ect2;dusp6;dmbt1;dbp;cry1;col3a1;cks2;ckap2;cdkn1a;ccnd1;ccl2;ccl12;atf5;aspm;asns;arntl;apoa2;apcs;alox15 VNN1_10157;TOP2A_10059;TF_10003;SREBF1_32750;SLPI_9890;SLC10A1_9832;SKA1_9829;PYCR1_9631;PLA2G2A_32641;PF4_32963;PCK1_9439;NREP_9364;NPAS2_9350;NFIL3_9304;NEFH_33218;NDRG1_32364;MYO1F_32715;MAFF_9172;LOXL2_9150;LOC100911740_32571;KNTC1_8976;KIF18B_32882;JUN_8938;HERPUD1_8795;HBB_8782;HBA2_32600;FGG_8639;ECT2_8523;DUSP6_8506;DMBT1_32993;DBP_8439;CRY1_8386;COL3A1_8354;CKS2_8325;CKAP2_8324;CDKN1A_8271;CCND1_8224;CCL2_8218;CCL12_8217;ATF5_8097;ASPM_8092;ASNS_8091;ARNTL_8086;APOA2_33095;APCS_8057;ALOX15_8036 50.19722782608697 52.6525 1.16694E-12 33.54508951661718 53.95250110405742 31.55465320340475 32.73891434782612 37.28215 1.16694E-12 22.067511298996603 34.80657871666544 20.672285539224873 108.09851521739135 94.7002 1.16694E-12 95.31551350855499 121.86289672564085 99.20472094540567 20.8684;13.8391;51.412;11.2357;56.5193;7.96762;11.9206;54.7122;1.16694E-12;105.82;5.51457;36.861;58.2312;33.1149;79.3182;99.6641;91.9576;58.0695;65.4434;91.003;7.89839;3.6768;57.7663;53.893;91.4283;101.406;93.1824;14.4142;45.5478;21.7434;50.6952;37.2548;57.8774;14.4197;12.1218;54.5478;28.2655;64.0097;25.5289;97.9563;10.3235;85.6642;38.2177;80.183;101.954;105.624 17.1194;9.31624;36.6131;4.94421;39.3315;6.07525;8.34831;38.3856;1.16694E-12;53.8521;1.34064;28.0333;35.795;25.603;39.4261;42.5546;61.1322;40.1293;43.7615;54.5666;3.83458;1.12034;38.6865;37.9512;54.7263;84.6435;51.338;9.59235;33.3115;12.6557;40.5862;21.8798;39.4215;9.6236;8.47044;38.2987;22.3101;41.1311;13.9582;75.2121;7.4611;53.6991;27.1236;50.2978;58.4986;83.8302 26.5474;27.6952;86.0232;24.5771;100.108;11.4863;21.0483;94.9303;1.16694E-12;109.875;39.6721;53.5645;99.4319;46.6318;264.141;105.409;110.707;104.733;129.393;273.335;12.5679;11.7489;109.049;92.6554;277.036;115.953;327.378;30.0753;71.7388;160.485;59.5346;73.8251;106.603;29.0958;21.3803;94.4701;38.3337;132.851;336.862;114.804;16.8623;224.488;63.2034;197.161;395.621;129.44 22 24 22 29142;360243;24825;78968;291441;287877;362282;314654;366960;304477;303575;85430;360504;361921;170568;498709;306575;58919;289054;25612;25649;81639 VNN1_10157;TOP2A_10059;TF_10003;SREBF1_32750;SKA1_9829;PYCR1_9631;PCK1_9439;MYO1F_32715;MAFF_9172;KNTC1_8976;KIF18B_32882;HERPUD1_8795;HBA2_32600;ECT2_8523;DMBT1_32993;CKS2_8325;CKAP2_8324;CCND1_8224;ASPM_8092;ASNS_8091;APOA2_33095;ALOX15_8036 39.0528709090909 21.3059 34.48009628586324 27.400864090909092 14.88755 25.958952053302784 73.46273636363637 39.0029 62.89299303605212 20.8684;13.8391;51.412;11.2357;11.9206;54.7122;5.51457;91.9576;58.0695;7.89839;3.6768;53.893;101.406;14.4142;21.7434;14.4197;12.1218;28.2655;10.3235;85.6642;80.183;105.624 17.1194;9.31624;36.6131;4.94421;8.34831;38.3856;1.34064;61.1322;40.1293;3.83458;1.12034;37.9512;84.6435;9.59235;12.6557;9.6236;8.47044;22.3101;7.4611;53.6991;50.2978;83.8302 26.5474;27.6952;86.0232;24.5771;21.0483;94.9303;39.6721;110.707;104.733;12.5679;11.7489;92.6554;115.953;30.0753;160.485;29.0958;21.3803;38.3337;16.8623;224.488;197.161;129.44 24 84386;24777;29692;360918;338475;316351;114519;24587;299923;290350;100911740;24516;24440;24367;116663;24309;299691;84032;114851;24770;287562;282840;29657;29339 SLPI_9890;SLC10A1_9832;PLA2G2A_32641;PF4_32963;NREP_9364;NPAS2_9350;NFIL3_9304;NEFH_33218;NDRG1_32364;LOXL2_9150;LOC100911740_32571;JUN_8938;HBB_8782;FGG_8639;DUSP6_8506;DBP_8439;CRY1_8386;COL3A1_8354;CDKN1A_8271;CCL2_8218;CCL12_8217;ATF5_8097;ARNTL_8086;APCS_8057 60.41288833333338 57.82185 29.806556083997304 37.63212708333338 39.3765 16.889843273006736 139.84797916666673 106.006 109.38092974315259 56.5193;7.96762;1.16694E-12;105.82;36.861;58.2312;33.1149;79.3182;99.6641;65.4434;91.003;57.7663;91.4283;93.1824;45.5478;50.6952;37.2548;57.8774;54.5478;64.0097;25.5289;97.9563;38.2177;101.954 39.3315;6.07525;1.16694E-12;53.8521;28.0333;35.795;25.603;39.4261;42.5546;43.7615;54.5666;38.6865;54.7263;51.338;33.3115;40.5862;21.8798;39.4215;38.2987;41.1311;13.9582;75.2121;27.1236;58.4986 100.108;11.4863;1.16694E-12;109.875;53.5645;99.4319;46.6318;264.141;105.409;129.393;273.335;109.049;277.036;327.378;71.7388;59.5346;73.8251;106.603;94.4701;132.851;336.862;114.804;63.2034;395.621 0 Exp 2,8(0.18);Exp 3,2(0.05);Exp 4,1(0.03);Exp 5,1(0.03);Hill,3(0.07);Linear,15(0.33);Poly 2,14(0.31);Power,2(0.05) 1.955544346049736 95.29031121730804 1.5226441621780396 5.737884044647217 0.8968570708192022 1.7789452075958252 40.503158735353495 59.89129691682048 26.361707362373178 39.116121333279054 80.553643920716 135.64338651406672 CONFLICT 0.4782608695652174 0.5217391304347826 0.0 GO:0031396 9 regulation of protein ubiquitination 54 58 2 2 2 2 2 2 67 56 2422 0.79368 0.47037 0.67 3.45 85430;299691 herpud1;cry1 HERPUD1_8795;CRY1_8386 45.5739 45.5739 37.2548 11.764984046738036 41.923121404958685 10.571588382072736 29.9155 29.9155 21.8798 11.36419592316147 26.389089504132233 10.211454696039496 83.24025 83.24025 73.8251 13.315032821777038 79.10847756198348 11.964406048187053 53.893;37.2548 37.9512;21.8798 92.6554;73.8251 1 1 1 85430 HERPUD1_8795 53.893 53.893 37.9512 37.9512 92.6554 92.6554 53.893 37.9512 92.6554 1 299691 CRY1_8386 37.2548 37.2548 21.8798 21.8798 73.8251 73.8251 37.2548 21.8798 73.8251 0 Exp 2,1(0.5);Linear,1(0.5) 1.686360689088556 3.3893336057662964 1.5270863771438599 1.8622472286224365 0.23699451086875886 1.6946668028831482 29.268464000000005 61.879335999999995 14.165528000000002 45.665472 64.78655600000002 101.69394399999999 CONFLICT 0.5 0.5 0.0 GO:0051171 5 regulation of nitrogen compound metabolic process 917 985 37 37 32 33 30 30 39 955 1523 0.83073 0.23892 0.45239 3.05 360243;24825;78968;84386;29692;360918;362282;316351;114519;366960;290350;24516;85430;24440;24367;361921;116663;24309;299691;498709;306575;114851;58919;24770;287562;282840;29657;25649;29339;81639 top2a;tf;srebf1;slpi;pla2g2a;pf4;pck1;npas2;nfil3;maff;loxl2;jun;herpud1;hbb;fgg;ect2;dusp6;dbp;cry1;cks2;ckap2;cdkn1a;ccnd1;ccl2;ccl12;atf5;arntl;apoa2;apcs;alox15 TOP2A_10059;TF_10003;SREBF1_32750;SLPI_9890;PLA2G2A_32641;PF4_32963;PCK1_9439;NPAS2_9350;NFIL3_9304;MAFF_9172;LOXL2_9150;JUN_8938;HERPUD1_8795;HBB_8782;FGG_8639;ECT2_8523;DUSP6_8506;DBP_8439;CRY1_8386;CKS2_8325;CKAP2_8324;CDKN1A_8271;CCND1_8224;CCL2_8218;CCL12_8217;ATF5_8097;ARNTL_8086;APOA2_33095;APCS_8057;ALOX15_8036 50.873669000000035 52.6525 1.16694E-12 31.797067217443487 55.7261748069827 28.7324134479758 33.58376266666671 37.28215 1.16694E-12 21.016702342379745 37.46889600658262 20.106124773517937 112.08849333333339 93.56275 1.16694E-12 99.46154123678404 129.63129443655978 103.52347822180369 13.8391;51.412;11.2357;56.5193;1.16694E-12;105.82;5.51457;58.2312;33.1149;58.0695;65.4434;57.7663;53.893;91.4283;93.1824;14.4142;45.5478;50.6952;37.2548;14.4197;12.1218;54.5478;28.2655;64.0097;25.5289;97.9563;38.2177;80.183;101.954;105.624 9.31624;36.6131;4.94421;39.3315;1.16694E-12;53.8521;1.34064;35.795;25.603;40.1293;43.7615;38.6865;37.9512;54.7263;51.338;9.59235;33.3115;40.5862;21.8798;9.6236;8.47044;38.2987;22.3101;41.1311;13.9582;75.2121;27.1236;50.2978;58.4986;83.8302 27.6952;86.0232;24.5771;100.108;1.16694E-12;109.875;39.6721;99.4319;46.6318;104.733;129.393;109.049;92.6554;277.036;327.378;30.0753;71.7388;59.5346;73.8251;29.0958;21.3803;94.4701;38.3337;132.851;336.862;114.804;63.2034;197.161;395.621;129.44 12 18 12 360243;24825;78968;362282;366960;85430;361921;498709;306575;58919;25649;81639 TOP2A_10059;TF_10003;SREBF1_32750;PCK1_9439;MAFF_9172;HERPUD1_8795;ECT2_8523;CKS2_8325;CKAP2_8324;CCND1_8224;APOA2_33095;ALOX15_8036 37.41600583333334 21.3426 32.21478279922616 26.201598333333333 15.966849999999999 24.452941955224507 68.40350833333333 39.0029 54.81814726651713 13.8391;51.412;11.2357;5.51457;58.0695;53.893;14.4142;14.4197;12.1218;28.2655;80.183;105.624 9.31624;36.6131;4.94421;1.34064;40.1293;37.9512;9.59235;9.6236;8.47044;22.3101;50.2978;83.8302 27.6952;86.0232;24.5771;39.6721;104.733;92.6554;30.0753;29.0958;21.3803;38.3337;197.161;129.44 18 84386;29692;360918;316351;114519;290350;24516;24440;24367;116663;24309;299691;114851;24770;287562;282840;29657;29339 SLPI_9890;PLA2G2A_32641;PF4_32963;NPAS2_9350;NFIL3_9304;LOXL2_9150;JUN_8938;HBB_8782;FGG_8639;DUSP6_8506;DBP_8439;CRY1_8386;CDKN1A_8271;CCL2_8218;CCL12_8217;ATF5_8097;ARNTL_8086;APCS_8057 59.845444444444496 57.1428 28.985455306294487 38.50520555555562 39.009 17.391706044395637 141.21181666666672 104.5785 112.63226659057727 56.5193;1.16694E-12;105.82;58.2312;33.1149;65.4434;57.7663;91.4283;93.1824;45.5478;50.6952;37.2548;54.5478;64.0097;25.5289;97.9563;38.2177;101.954 39.3315;1.16694E-12;53.8521;35.795;25.603;43.7615;38.6865;54.7263;51.338;33.3115;40.5862;21.8798;38.2987;41.1311;13.9582;75.2121;27.1236;58.4986 100.108;1.16694E-12;109.875;99.4319;46.6318;129.393;109.049;277.036;327.378;71.7388;59.5346;73.8251;94.4701;132.851;336.862;114.804;63.2034;395.621 0 Exp 2,4(0.14);Exp 3,1(0.04);Hill,3(0.1);Linear,12(0.4);Poly 2,8(0.27);Power,2(0.07) 2.065508732111754 66.69709587097168 1.5230457782745361 5.737884044647217 1.0619278200948112 1.8510428071022034 39.49523462803219 62.252103371967905 26.063032321235255 41.10449301209816 76.49663790345033 147.68034876321641 DOWN 0.4 0.6 0.0 GO:0060135 4 maternal process involved in female pregnancy 17 18 3 2 2 3 2 2 67 16 2462 0.9884 0.083748 0.083748 11.11 29680;24770 cyp11a1;ccl2 CYP11A1_32785;CCL2_8218 53.86435 53.86435 43.719 14.347691565021835 55.86225016001707 14.066735340732327 37.307950000000005 37.307950000000005 33.4848 5.406750580986667 38.06083403029657 5.300875693585808 98.37705 98.37705 63.9031 48.753527638571974 105.165924727971 47.798836984395656 0.0 43.719 0.5 53.86435 43.719;64.0097 33.4848;41.1311 63.9031;132.851 1 1 1 29680 CYP11A1_32785 43.719 43.719 33.4848 33.4848 63.9031 63.9031 43.719 33.4848 63.9031 1 24770 CCL2_8218 64.0097 64.0097 41.1311 41.1311 132.851 132.851 64.0097 41.1311 132.851 0 Exp 2,2(1) 1.6535578517830787 3.312731146812439 1.559963583946228 1.752767562866211 0.13633300093406808 1.6563655734062195 33.97946400000001 73.749236 29.814576000000002 44.80132400000001 30.808108000000004 165.945992 CONFLICT 0.5 0.5 0.0 GO:0071396 6 cellular response to lipid 195 209 10 10 9 10 9 9 60 200 2278 0.94796 0.1077 0.17552 4.31 78968;360918;362282;24587;24516;79438;24450;29680;24770 srebf1;pf4;pck1;nefh;jun;igfals;hmgcs2;cyp11a1;ccl2 SREBF1_32750;PF4_32963;PCK1_9439;NEFH_33218;JUN_8938;IGFALS_8880;HMGCS2_8812;CYP11A1_32785;CCL2_8218 52.03869666666666 57.7663 5.51457 32.609219516585334 57.83733845890697 26.43428472844557 31.49870555555556 38.6865 1.34064 17.975993835472014 35.23136563788069 13.551513080175921 103.71443333333335 109.049 24.5771 74.68369638423432 129.86495920456127 85.73980586166076 11.2357;105.82;5.51457;79.3182;57.7663;70.3663;30.5985;43.719;64.0097 4.94421;53.8521;1.34064;39.4261;38.6865;46.0459;24.577;33.4848;41.1311 24.5771;109.875;39.6721;264.141;109.049;148.796;40.5656;63.9031;132.851 4 5 4 78968;362282;24450;29680 SREBF1_32750;PCK1_9439;HMGCS2_8812;CYP11A1_32785 22.7669425 20.9171 17.61567405117457 16.086662500000003 14.760605000000002 15.452944127447848 42.179475000000004 40.11885 16.23423348655035 11.2357;5.51457;30.5985;43.719 4.94421;1.34064;24.577;33.4848 24.5771;39.6721;40.5656;63.9031 5 360918;24587;24516;79438;24770 PF4_32963;NEFH_33218;JUN_8938;IGFALS_8880;CCL2_8218 75.45609999999999 70.3663 18.753249056230256 43.828340000000004 41.1311 6.2945745708506635 152.9424 132.851 64.3572395601303 105.82;79.3182;57.7663;70.3663;64.0097 53.8521;39.4261;38.6865;46.0459;41.1311 109.875;264.141;109.049;148.796;132.851 0 Exp 2,5(0.56);Exp 3,1(0.12);Hill,2(0.23);Linear,1(0.12) 1.979580622877423 18.541324019432068 1.5230457782745361 3.3687045574188232 0.6595674652325719 1.7671042680740356 30.73400658249758 73.34338675083575 19.75438958304718 43.24302152806394 54.9210850289669 152.5077816376998 CONFLICT 0.4444444444444444 0.5555555555555556 0.0 GO:2000113 8 negative regulation of cellular macromolecule biosynthetic process 254 266 10 10 9 10 9 9 60 257 2221 0.82276 0.29024 0.42727 3.38 78968;114519;290350;24516;299691;114851;58919;282840;29657 srebf1;nfil3;loxl2;jun;cry1;cdkn1a;ccnd1;atf5;arntl SREBF1_32750;NFIL3_9304;LOXL2_9150;JUN_8938;CRY1_8386;CDKN1A_8271;CCND1_8224;ATF5_8097;ARNTL_8086 47.08915555555555 38.2177 11.2357 25.259836792926393 51.789575342073725 24.27616808015491 33.09105666666667 27.1236 4.94421 19.59692896631128 36.506492203938535 19.18401347107188 77.14302222222221 73.8251 24.5771 36.86499778705331 84.21830632098589 33.10960264313187 11.2357;33.1149;65.4434;57.7663;37.2548;54.5478;28.2655;97.9563;38.2177 4.94421;25.603;43.7615;38.6865;21.8798;38.2987;22.3101;75.2121;27.1236 24.5771;46.6318;129.393;109.049;73.8251;94.4701;38.3337;114.804;63.2034 2 7 2 78968;58919 SREBF1_32750;CCND1_8224 19.7506 19.7506 12.04188706225067 13.627154999999998 13.627154999999998 12.279538580339652 31.4554 31.4554 9.727385146070851 11.2357;28.2655 4.94421;22.3101 24.5771;38.3337 7 114519;290350;24516;299691;114851;282840;29657 NFIL3_9304;LOXL2_9150;JUN_8938;CRY1_8386;CDKN1A_8271;ATF5_8097;ARNTL_8086 54.900171428571426 54.5478 22.50033618976351 38.65217142857143 38.2987 18.015553528337133 90.19662857142858 94.4701 30.028065631045617 33.1149;65.4434;57.7663;37.2548;54.5478;97.9563;38.2177 25.603;43.7615;38.6865;21.8798;38.2987;75.2121;27.1236 46.6318;129.393;109.049;73.8251;94.4701;114.804;63.2034 0 Exp 2,2(0.23);Hill,1(0.12);Linear,4(0.45);Poly 2,1(0.12);Power,1(0.12) 2.294217532950346 22.03081178665161 1.5230457782745361 4.897102355957031 1.0410208465667754 2.2675669193267822 30.586062184176985 63.59224892693413 20.287729742009965 45.89438359132337 53.057890334680735 101.22815410976372 DOWN 0.2222222222222222 0.7777777777777778 0.0 GO:0032354 6 response to follicle-stimulating hormone 20 22 3 3 3 3 3 3 66 19 2459 0.9975 0.020267 0.020267 13.64 24825;29680;25612 tf;cyp11a1;asns TF_10003;CYP11A1_32785;ASNS_8091 60.26506666666666 51.412 43.719 22.330081567547712 65.52076279612348 22.539763527903567 41.26566666666667 36.6131 33.4848 10.880683046727023 43.77073257358221 11.073141538813687 124.80476666666668 86.0232 63.9031 87.03381504819451 144.57434987437188 88.98531582979405 0.5 47.5655 1.5 68.5381 51.412;43.719;85.6642 36.6131;33.4848;53.6991 86.0232;63.9031;224.488 3 0 3 24825;29680;25612 TF_10003;CYP11A1_32785;ASNS_8091 60.26506666666666 51.412 22.330081567547712 41.26566666666667 36.6131 10.880683046727023 124.80476666666668 86.0232 87.03381504819451 51.412;43.719;85.6642 36.6131;33.4848;53.6991 86.0232;63.9031;224.488 0 0 Exp 2,2(0.67);Linear,1(0.34) 1.7766866846690164 5.353601813316345 1.5959433317184448 2.0048909187316895 0.20631616311376494 1.752767562866211 34.99620060272874 85.53393273060459 28.95301470611675 53.57831862721659 26.316733435183238 223.2927998981501 UP 1.0 0.0 0.0 GO:0034641 4 cellular nitrogen compound metabolic process 478 543 15 13 13 13 11 11 58 532 1946 0.16979 0.89868 0.30031 2.03 29142;360847;360243;78968;362282;114519;293502;24516;24450;24440;25612 vnn1;ube2t;top2a;srebf1;pck1;nfil3;kif22;jun;hmgcs2;hbb;asns VNN1_10157;UBE2T_10125;TOP2A_10059;SREBF1_32750;PCK1_9439;NFIL3_9304;KIF22_8963;JUN_8938;HMGCS2_8812;HBB_8782;ASNS_8091 34.02367909090909 20.8684 5.51457 30.681147601910347 38.528026345415874 30.0205291394425 22.445390000000003 17.1194 1.34064 19.084961962017108 25.921082161118026 18.39930238254716 78.173 39.6721 18.2059 89.58932645245191 83.85664040136902 88.0169710389132 20.8684;10.9914;13.8391;11.2357;5.51457;33.1149;13.2391;57.7663;30.5985;91.4283;85.6642 17.1194;7.86591;9.31624;4.94421;1.34064;25.603;9.02099;38.6865;24.577;54.7263;53.6991 26.5474;18.2059;27.6952;24.5771;39.6721;46.6318;25.4349;109.049;40.5656;277.036;224.488 8 3 8 29142;360847;360243;78968;362282;293502;24450;25612 VNN1_10157;UBE2T_10125;TOP2A_10059;SREBF1_32750;PCK1_9439;KIF22_8963;HMGCS2_8812;ASNS_8091 23.993871249999998 13.539100000000001 26.04590285935387 15.985436250000001 9.168614999999999 16.872244350356624 53.398275 27.121299999999998 69.54701463141421 20.8684;10.9914;13.8391;11.2357;5.51457;13.2391;30.5985;85.6642 17.1194;7.86591;9.31624;4.94421;1.34064;9.02099;24.577;53.6991 26.5474;18.2059;27.6952;24.5771;39.6721;25.4349;40.5656;224.488 3 114519;24516;24440 NFIL3_9304;JUN_8938;HBB_8782 60.76983333333334 57.7663 29.272496720528167 39.671933333333335 38.6865 14.58663634507053 144.23893333333334 109.049 119.1648958393928 33.1149;57.7663;91.4283 25.603;38.6865;54.7263 46.6318;109.049;277.036 0 Exp 2,4(0.37);Hill,2(0.19);Linear,2(0.19);Poly 2,3(0.28) 2.1776754956403366 24.797737956047058 1.5230457782745361 3.3687045574188232 0.6218688590026626 2.3449018001556396 15.89227952029309 52.155078661525096 11.166898216928828 33.72388178307118 25.22909137414984 131.11690862585016 UP 0.7272727272727273 0.2727272727272727 0.0 GO:1901700 4 response to oxygen-containing compound 599 638 34 32 30 30 27 27 42 611 1867 0.99708 0.0062332 0.010461 4.23 24825;78968;84386;24777;25044;83792;360918;362282;24587;58827;24516;79438;24450;24440;360504;316033;81660;361921;25086;29680;299691;84032;114851;58919;24770;25612;25649 tf;srebf1;slpi;slc10a1;sds;scd2;pf4;pck1;nefh;mest;jun;igfals;hmgcs2;hbb;hba-a2;glb1;gatm;ect2;cyp2e1;cyp11a1;cry1;col3a1;cdkn1a;ccnd1;ccl2;asns;apoa2 TF_10003;SREBF1_32750;SLPI_9890;SLC10A1_9832;SDS_9798;SCD_9786;PF4_32963;PCK1_9439;NEFH_33218;MEST_9219;JUN_8938;IGFALS_8880;HMGCS2_8812;HBB_8782;HBA2_32600;GLB1_8712;GATM_32792;ECT2_8523;CYP2E1_8421;CYP11A1_32785;CRY1_8386;COL3A1_8354;CDKN1A_8271;CCND1_8224;CCL2_8218;ASNS_8091;APOA2_33095 56.80871074074074 57.7663 5.51457 28.83349826560591 56.284351036846004 25.112957973148397 36.94876111111112 39.3315 1.34064 18.694953822013712 36.44808391977792 15.050339907215347 118.34587407407409 106.603 11.4863 82.79752074021201 122.2299126752788 82.34620503886563 51.412;11.2357;56.5193;7.96762;64.7394;83.9984;105.82;5.51457;79.3182;96.9172;57.7663;70.3663;30.5985;91.4283;101.406;65.9159;37.423;14.4142;49.5529;43.719;37.2548;57.8774;54.5478;28.2655;64.0097;85.6642;80.183 36.6131;4.94421;39.3315;6.07525;43.4259;54.1928;53.8521;1.34064;39.4261;56.7353;38.6865;46.0459;24.577;54.7263;84.6435;47.8573;28.03;9.59235;26.9979;33.4848;21.8798;39.4215;38.2987;22.3101;41.1311;53.6991;50.2978 86.0232;24.5771;100.108;11.4863;126.828;206.18;109.875;39.6721;264.141;331.492;109.049;148.796;40.5656;277.036;115.953;114.587;55.6613;30.0753;71.5977;63.9031;73.8251;106.603;94.4701;38.3337;132.851;224.488;197.161 13 14 13 24825;78968;83792;362282;24450;360504;316033;361921;25086;29680;58919;25612;25649 TF_10003;SREBF1_32750;SCD_9786;PCK1_9439;HMGCS2_8812;HBA2_32600;GLB1_8712;ECT2_8523;CYP2E1_8421;CYP11A1_32785;CCND1_8224;ASNS_8091;APOA2_33095 50.14460538461538 49.5529 31.454842786936275 34.657738461538464 33.4848 23.453433862420102 96.3936 71.5977 70.92699000593262 51.412;11.2357;83.9984;5.51457;30.5985;101.406;65.9159;14.4142;49.5529;43.719;28.2655;85.6642;80.183 36.6131;4.94421;54.1928;1.34064;24.577;84.6435;47.8573;9.59235;26.9979;33.4848;22.3101;53.6991;50.2978 86.0232;24.5771;206.18;39.6721;40.5656;115.953;114.587;30.0753;71.5977;63.9031;38.3337;224.488;197.161 14 84386;24777;25044;360918;24587;58827;24516;79438;24440;81660;299691;84032;114851;24770 SLPI_9890;SLC10A1_9832;SDS_9798;PF4_32963;NEFH_33218;MEST_9219;JUN_8938;IGFALS_8880;HBB_8782;GATM_32792;CRY1_8386;COL3A1_8354;CDKN1A_8271;CCL2_8218 62.99680857142857 60.94355 25.76419831382206 39.07613928571429 39.4238 13.458416030358938 138.73012857142857 109.462 90.20981121046842 56.5193;7.96762;64.7394;105.82;79.3182;96.9172;57.7663;70.3663;91.4283;37.423;37.2548;57.8774;54.5478;64.0097 39.3315;6.07525;43.4259;53.8521;39.4261;56.7353;38.6865;46.0459;54.7263;28.03;21.8798;39.4215;38.2987;41.1311 100.108;11.4863;126.828;109.875;264.141;331.492;109.049;148.796;277.036;55.6613;73.8251;106.603;94.4701;132.851 0 Exp 2,11(0.41);Exp 3,1(0.04);Hill,2(0.08);Linear,9(0.34);Poly 2,4(0.15) 1.931896216588615 53.171600580215454 1.5230457782745361 3.3687045574188232 0.42422698298277645 1.8622472286224365 45.9326524569943 67.68476902448718 29.896983851647974 44.00053837057425 87.11446909417867 149.57727905396953 CONFLICT 0.48148148148148145 0.5185185185185185 0.0 GO:0050673 4 epithelial cell proliferation 37 39 2 2 2 2 2 2 67 37 2441 0.913 0.28537 0.28537 5.13 290350;58919 loxl2;ccnd1 LOXL2_9150;CCND1_8224 46.85445 46.85445 28.2655 26.288745200275333 47.832815789473685 26.252308945480866 33.035799999999995 33.035799999999995 22.3101 15.168430405945134 33.60031052631579 15.147406930275464 83.86335 83.86335 38.3337 64.38864852010022 86.25964736842106 64.29940572112 0.5 46.85445 65.4434;28.2655 43.7615;22.3101 129.393;38.3337 1 1 1 58919 CCND1_8224 28.2655 28.2655 22.3101 22.3101 38.3337 38.3337 28.2655 22.3101 38.3337 1 290350 LOXL2_9150 65.4434 65.4434 43.7615 43.7615 129.393 129.393 65.4434 43.7615 129.393 0 Linear,2(1) 1.984829642009808 4.004913091659546 1.7373461723327637 2.2675669193267822 0.37492268572526727 2.002456545829773 10.420108000000013 83.28879199999999 12.013427999999994 54.058172 -5.374763999999999 173.101464 CONFLICT 0.5 0.5 0.0 GO:0007166 5 cell surface receptor signaling pathway 368 386 8 8 7 7 7 7 62 379 2099 0.15651 0.91727 0.30674 1.81 78968;360918;24516;84032;58919;24770;287562 srebf1;pf4;jun;col3a1;ccnd1;ccl2;ccl12 SREBF1_32750;PF4_32963;JUN_8938;COL3A1_8354;CCND1_8224;CCL2_8218;CCL12_8217 50.071928571428565 57.7663 11.2357 31.64482818317049 41.67247609195403 25.88980184758765 30.61481571428572 38.6865 4.94421 17.314081645471756 26.113561339166242 15.009053829190718 122.59297142857145 109.049 24.5771 102.73269909032068 165.62496174987135 134.34630100360783 11.2357;105.82;57.7663;57.8774;28.2655;64.0097;25.5289 4.94421;53.8521;38.6865;39.4215;22.3101;41.1311;13.9582 24.5771;109.875;109.049;106.603;38.3337;132.851;336.862 2 5 2 78968;58919 SREBF1_32750;CCND1_8224 19.7506 19.7506 12.04188706225067 13.627154999999998 13.627154999999998 12.279538580339652 31.4554 31.4554 9.727385146070851 11.2357;28.2655 4.94421;22.3101 24.5771;38.3337 5 360918;24516;84032;24770;287562 PF4_32963;JUN_8938;COL3A1_8354;CCL2_8218;CCL12_8217 62.20046 57.8774 28.67530102148886 37.40988 39.4215 14.490097871374081 159.048 109.875 99.96557327400268 105.82;57.7663;57.8774;64.0097;25.5289 53.8521;38.6865;39.4215;41.1311;13.9582 109.875;109.049;106.603;132.851;336.862 0 Exp 2,3(0.43);Exp 3,1(0.15);Hill,1(0.15);Linear,1(0.15);Poly 2,1(0.15) 1.8308098386090745 13.168776631355286 1.5230457782745361 2.857419490814209 0.5070960654741409 1.589477300643921 26.62911178829821 73.51474535455893 17.788364534537564 43.44126689403387 46.48752290249381 198.69841995464907 DOWN 0.2857142857142857 0.7142857142857143 0.0 GO:0032956 6 regulation of actin cytoskeleton organization 79 82 3 3 3 3 3 3 66 79 2399 0.81993 0.38468 0.48603 3.66 314654;361921;81639 myo1f;ect2;alox15 MYO1F_32715;ECT2_8523;ALOX15_8036 70.66526666666665 91.9576 14.4142 49.19176250240821 77.63218858195211 47.31826321625533 51.51825 61.1322 9.59235 38.04123577261258 58.02257887802806 37.63355346744103 90.0741 110.707 30.0753 52.79794809772438 97.94087809888087 51.13251797662393 91.9576;14.4142;105.624 61.1322;9.59235;83.8302 110.707;30.0753;129.44 3 0 3 314654;361921;81639 MYO1F_32715;ECT2_8523;ALOX15_8036 70.66526666666665 91.9576 49.19176250240821 51.51825 61.1322 38.04123577261258 90.0741 110.707 52.79794809772438 91.9576;14.4142;105.624 61.1322;9.59235;83.8302 110.707;30.0753;129.44 0 0 Poly 2,3(1) 1.6840011115133449 5.0575889348983765 1.5863633155822754 1.7797720432281494 0.09682548770919511 1.6914535760879517 14.999547114218736 126.3309862191146 8.470539281297143 94.56596071870285 30.327597288113097 149.82060271188692 UP 1.0 0.0 0.0 GO:0033273 5 response to vitamin 73 78 7 7 7 4 4 4 65 74 2404 0.9421 0.15875 0.15875 5.13 25044;29680;58919;24770 sds;cyp11a1;ccnd1;ccl2 SDS_9798;CYP11A1_32785;CCND1_8224;CCL2_8218 50.18339999999999 53.86435 28.2655 17.56157277941438 47.50683827552674 19.568717002288935 35.087975 37.307950000000005 22.3101 9.51988467485296 33.380850612641815 10.942165733116488 90.47895 95.36555 38.3337 46.69777638492724 84.98005128687198 49.789800095582464 2.5 64.37455 64.7394;43.719;28.2655;64.0097 43.4259;33.4848;22.3101;41.1311 126.828;63.9031;38.3337;132.851 2 2 2 29680;58919 CYP11A1_32785;CCND1_8224 35.99225 35.99225 10.927274643066331 27.89745 27.89745 7.901706147725311 51.1184 51.1184 18.08029613087131 43.719;28.2655 33.4848;22.3101 63.9031;38.3337 2 25044;24770 SDS_9798;CCL2_8218 64.37455 64.37455 0.5159758182314222 42.2785 42.2785 1.6226686414668818 129.8395 129.8395 4.258904143088003 64.7394;64.0097 43.4259;41.1311 126.828;132.851 0 Exp 2,2(0.5);Linear,2(0.5) 1.8569893731914708 7.498254656791687 1.559963583946228 2.2675669193267822 0.300078881519591 1.8353620767593384 32.97305867617395 67.39374132382606 25.758488018644112 44.417461981355885 44.71512914277132 136.24277085722866 CONFLICT 0.5 0.5 0.0 GO:0006810 4 transport 570 605 22 21 20 21 19 19 50 586 1892 0.81519 0.26766 0.47344 3.14 24825;29503;24777;29692;314654;286918;290350;287167;85430;24440;360504;24367;170568;114851;58919;287562;29657;25649;81639 tf;slc22a2;slc10a1;pla2g2a;myo1f;mx2;loxl2;hba-a1;herpud1;hbb;hba-a2;fgg;dmbt1;cdkn1a;ccnd1;ccl12;arntl;apoa2;alox15 TF_10003;SLC22A2_9845;SLC10A1_9832;PLA2G2A_32641;MYO1F_32715;MX2_9268;LOXL2_9150;LOC287167_9118;HERPUD1_8795;HBB_8782;HBA2_32600;FGG_8639;DMBT1_32993;CDKN1A_8271;CCND1_8224;CCL12_8217;ARNTL_8086;APOA2_33095;ALOX15_8036 59.44663263157901 54.5478 1.16694E-12 34.352275856193316 53.01953469212163 30.80277531243489 40.8799078947369 38.2987 1.16694E-12 25.345145955895056 36.466196141264376 22.564857939593487 128.93153157894744 110.707 1.16694E-12 95.87699583574683 131.67486140738407 98.35420474964977 51.412;81.8219;7.96762;1.16694E-12;91.9576;31.6605;65.4434;105.203;53.893;91.4283;101.406;93.1824;21.7434;54.5478;28.2655;25.5289;38.2177;80.183;105.624 36.6131;46.3605;6.07525;1.16694E-12;61.1322;23.5989;43.7615;82.0435;37.9512;54.7263;84.6435;51.338;12.6557;38.2987;22.3101;13.9582;27.1236;50.2978;83.8302 86.0232;102.079;11.4863;1.16694E-12;110.707;46.786;129.393;130.247;92.6554;277.036;115.953;327.378;160.485;94.4701;38.3337;336.862;63.2034;197.161;129.44 10 9 10 24825;29503;314654;287167;85430;360504;170568;58919;25649;81639 TF_10003;SLC22A2_9845;MYO1F_32715;LOC287167_9118;HERPUD1_8795;HBA2_32600;DMBT1_32993;CCND1_8224;APOA2_33095;ALOX15_8036 72.15094 81.00245000000001 31.35707633293213 51.78378 48.32915 25.73927436846484 116.30843 113.33 43.006624562632446 51.412;81.8219;91.9576;105.203;53.893;101.406;21.7434;28.2655;80.183;105.624 36.6131;46.3605;61.1322;82.0435;37.9512;84.6435;12.6557;22.3101;50.2978;83.8302 86.0232;102.079;110.707;130.247;92.6554;115.953;160.485;38.3337;197.161;129.44 9 24777;29692;286918;290350;24440;24367;114851;287562;29657 SLC10A1_9832;PLA2G2A_32641;MX2_9268;LOXL2_9150;HBB_8782;FGG_8639;CDKN1A_8271;CCL12_8217;ARNTL_8086 45.330735555555684 38.2177 33.51250155202331 28.76449444444457 27.1236 19.65384810222338 142.95720000000014 94.4701 134.8393214328167 7.96762;1.16694E-12;31.6605;65.4434;91.4283;93.1824;54.5478;25.5289;38.2177 6.07525;1.16694E-12;23.5989;43.7615;54.7263;51.338;38.2987;13.9582;27.1236 11.4863;1.16694E-12;46.786;129.393;277.036;327.378;94.4701;336.862;63.2034 0 Exp 2,2(0.11);Hill,1(0.06);Linear,7(0.37);Poly 2,8(0.43);Power,1(0.06) 1.9334174999682276 38.36652624607086 1.5270863771438599 4.897102355957031 0.7629013243592404 1.7553097009658813 43.99996558326078 74.89329967989725 29.483340386061716 52.27647540341212 85.81997651146064 172.04308664643423 CONFLICT 0.5263157894736842 0.47368421052631576 0.0 GO:0045595 5 regulation of cell differentiation 433 456 19 19 17 17 15 15 54 441 2037 0.84212 0.24181 0.42501 3.29 29142;24825;360918;338475;366960;290350;24516;361921;170568;84032;58919;282840;289054;29657;29339 vnn1;tf;pf4;nrep;maff;loxl2;jun;ect2;dmbt1;col3a1;ccnd1;atf5;aspm;arntl;apcs VNN1_10157;TF_10003;PF4_32963;NREP_9364;MAFF_9172;LOXL2_9150;JUN_8938;ECT2_8523;DMBT1_32993;COL3A1_8354;CCND1_8224;ATF5_8097;ASPM_8092;ARNTL_8086;APCS_8057 51.13284 51.412 10.3235 31.39054581684928 55.249015026215105 31.486575743337692 34.03135 36.6131 7.4611 19.16818363802557 37.331417931132215 20.433766554521934 103.01152000000002 104.733 16.8623 91.39694980383409 121.21755781068443 107.8145955078005 20.8684;51.412;105.82;36.861;58.0695;65.4434;57.7663;14.4142;21.7434;57.8774;28.2655;97.9563;10.3235;38.2177;101.954 17.1194;36.6131;53.8521;28.0333;40.1293;43.7615;38.6865;9.59235;12.6557;39.4215;22.3101;75.2121;7.4611;27.1236;58.4986 26.5474;86.0232;109.875;53.5645;104.733;129.393;109.049;30.0753;160.485;106.603;38.3337;114.804;16.8623;63.2034;395.621 7 8 7 29142;24825;366960;361921;170568;58919;289054 VNN1_10157;TF_10003;MAFF_9172;ECT2_8523;DMBT1_32993;CCND1_8224;ASPM_8092 29.299500000000002 21.7434 18.382888505165155 20.840149999999998 17.1194 12.970217156592511 66.1514142857143 38.3337 53.002292406505994 20.8684;51.412;58.0695;14.4142;21.7434;28.2655;10.3235 17.1194;36.6131;40.1293;9.59235;12.6557;22.3101;7.4611 26.5474;86.0232;104.733;30.0753;160.485;38.3337;16.8623 8 360918;338475;290350;24516;84032;282840;29657;29339 PF4_32963;NREP_9364;LOXL2_9150;JUN_8938;COL3A1_8354;ATF5_8097;ARNTL_8086;APCS_8057 70.23701249999999 61.660399999999996 28.058426772384284 45.57365000000001 41.591499999999996 16.25976050078403 135.2641125 109.462 108.40378652421217 105.82;36.861;65.4434;57.7663;57.8774;97.9563;38.2177;101.954 53.8521;28.0333;43.7615;38.6865;39.4215;75.2121;27.1236;58.4986 109.875;53.5645;129.393;109.049;106.603;114.804;63.2034;395.621 0 Exp 2,3(0.2);Exp 3,1(0.07);Linear,6(0.4);Poly 2,4(0.27);Power,1(0.07) 1.9550228334133697 30.905868649482727 1.5230457782745361 4.897102355957031 0.852509386794319 1.7797720432281494 35.24703200620297 67.01864799379705 24.330910681736512 43.731789318263495 56.75828170737115 149.2647582926289 CONFLICT 0.4666666666666667 0.5333333333333333 0.0 GO:0044260 4 cellular macromolecule metabolic process 676 733 27 25 23 27 22 22 47 711 1767 0.76456 0.32386 0.59012 3.0 360847;360243;24825;78968;362282;114519;286918;290350;293502;24516;85430;362376;171142;116663;299691;84032;297594;58919;24770;287562;29657;25649 ube2t;top2a;tf;srebf1;pck1;nfil3;mx2;loxl2;kif22;jun;herpud1;herc6;ehhadh;dusp6;cry1;col3a1;cdca3;ccnd1;ccl2;ccl12;arntl;apoa2 UBE2T_10125;TOP2A_10059;TF_10003;SREBF1_32750;PCK1_9439;NFIL3_9304;MX2_9268;LOXL2_9150;KIF22_8963;JUN_8938;HERPUD1_8795;HERC6_8794;EHHADH_8534;DUSP6_8506;CRY1_8386;COL3A1_8354;CDCA3_8260;CCND1_8224;CCL2_8218;CCL12_8217;ARNTL_8086;APOA2_33095 37.006485 35.18485 2.6193 21.828440228485615 40.7845498436762 20.425980130501426 25.04984740909091 25.6233 0.978353 14.84482981841195 27.45425909622861 13.501554085395872 82.64066681818181 67.4711 7.96997 72.98078931840595 101.84733053700542 88.38326215532909 10.9914;13.8391;51.412;11.2357;5.51457;33.1149;31.6605;65.4434;13.2391;57.7663;53.893;53.833;32.6956;45.5478;37.2548;57.8774;2.6193;28.2655;64.0097;25.5289;38.2177;80.183 7.86591;9.31624;36.6131;4.94421;1.34064;25.603;23.5989;43.7615;9.02099;38.6865;37.9512;36.3389;25.6436;33.3115;21.8798;39.4215;0.978353;22.3101;41.1311;13.9582;27.1236;50.2978 18.2059;27.6952;86.0232;24.5771;39.6721;46.6318;46.786;129.393;25.4349;109.049;92.6554;98.3689;45.0542;71.7388;73.8251;106.603;7.96997;38.3337;132.851;336.862;63.2034;197.161 11 11 11 360847;360243;24825;78968;362282;293502;85430;171142;297594;58919;25649 UBE2T_10125;TOP2A_10059;TF_10003;SREBF1_32750;PCK1_9439;KIF22_8963;HERPUD1_8795;EHHADH_8534;CDCA3_8260;CCND1_8224;APOA2_33095 27.626206363636367 13.8391 24.699677880382275 18.75292209090909 9.31624 16.896348764177844 54.79842454545455 38.3337 54.140677556628596 10.9914;13.8391;51.412;11.2357;5.51457;13.2391;53.893;32.6956;2.6193;28.2655;80.183 7.86591;9.31624;36.6131;4.94421;1.34064;9.02099;37.9512;25.6436;0.978353;22.3101;50.2978 18.2059;27.6952;86.0232;24.5771;39.6721;25.4349;92.6554;45.0542;7.96997;38.3337;197.161 11 114519;286918;290350;24516;362376;116663;299691;84032;24770;287562;29657 NFIL3_9304;MX2_9268;LOXL2_9150;JUN_8938;HERC6_8794;DUSP6_8506;CRY1_8386;COL3A1_8354;CCL2_8218;CCL12_8217;ARNTL_8086 46.38676363636364 45.5478 14.034187488149968 31.34677272727273 33.3115 9.489754987889933 110.4829090909091 98.3689 80.92205393609898 33.1149;31.6605;65.4434;57.7663;53.833;45.5478;37.2548;57.8774;64.0097;25.5289;38.2177 25.603;23.5989;43.7615;38.6865;36.3389;33.3115;21.8798;39.4215;41.1311;13.9582;27.1236 46.6318;46.786;129.393;109.049;98.3689;71.7388;73.8251;106.603;132.851;336.862;63.2034 0 Exp 2,7(0.32);Exp 4,1(0.05);Hill,2(0.1);Linear,7(0.32);Poly 2,4(0.19);Power,1(0.05) 2.0080267413349353 46.260642409324646 1.5089621543884277 4.897102355957031 0.7621260431375555 1.8783162832260132 27.884960376468044 46.128009623531966 18.84658784022431 31.253106977957515 52.14393595493303 113.1373976814306 CONFLICT 0.5 0.5 0.0 GO:0008152 2 metabolic process 1361 1509 60 56 53 52 44 44 25 1465 1013 0.8153 0.2591 0.45916 2.92 29142;360847;360243;24825;78968;25044;83792;287877;29692;362282;114519;286918;290350;287167;293502;24516;24450;85430;362376;24440;360504;316033;81660;24367;171142;29740;116663;24306;25086;499353;29680;299691;84032;498709;114851;297594;58919;24770;287562;791259;25612;29657;25649;81639 vnn1;ube2t;top2a;tf;srebf1;sds;scd2;pycr1;pla2g2a;pck1;nfil3;mx2;loxl2;hba-a1;kif22;jun;hmgcs2;herpud1;herc6;hbb;hba-a2;glb1;gatm;fgg;ehhadh;eci1;dusp6;cyp4a2;cyp2e1;cyp2c24;cyp11a1;cry1;col3a1;cks2;cdkn1a;cdca3;ccnd1;ccl2;ccl12;car14;asns;arntl;apoa2;alox15 VNN1_10157;UBE2T_10125;TOP2A_10059;TF_10003;SREBF1_32750;SDS_9798;SCD_9786;PYCR1_9631;PLA2G2A_32641;PCK1_9439;NFIL3_9304;MX2_9268;LOXL2_9150;LOC287167_9118;KIF22_8963;JUN_8938;HMGCS2_8812;HERPUD1_8795;HERC6_8794;HBB_8782;HBA2_32600;GLB1_8712;GATM_32792;FGG_8639;EHHADH_8534;ECI1_8520;DUSP6_8506;CYP4A2_8425;CYP2E1_8421;CYP2C24_32875;CYP11A1_32785;CRY1_8386;COL3A1_8354;CKS2_8325;CDKN1A_8271;CDCA3_8260;CCND1_8224;CCL2_8218;CCL12_8217;CAR14_8195;ASNS_8091;ARNTL_8086;APOA2_33095;ALOX15_8036 49.74279931818183 50.48245 1.16694E-12 30.8837090219185 50.19642794350969 27.595300185939934 33.645866659090935 34.91185 1.16694E-12 21.195381446166706 33.91354722985019 18.47877192419398 102.88906522727275 89.33930000000001 1.16694E-12 87.81213439789798 110.8807482581584 90.89743860482722 20.8684;10.9914;13.8391;51.412;11.2357;64.7394;83.9984;54.7122;1.16694E-12;5.51457;33.1149;31.6605;65.4434;105.203;13.2391;57.7663;30.5985;53.893;53.833;91.4283;101.406;65.9159;37.423;93.1824;32.6956;103.231;45.5478;59.5671;49.5529;10.5651;43.719;37.2548;57.8774;14.4197;54.5478;2.6193;28.2655;64.0097;25.5289;98.1742;85.6642;38.2177;80.183;105.624 17.1194;7.86591;9.31624;36.6131;4.94421;43.4259;54.1928;38.3856;1.16694E-12;1.34064;25.603;23.5989;43.7615;82.0435;9.02099;38.6865;24.577;37.9512;36.3389;54.7263;84.6435;47.8573;28.03;51.338;25.6436;49.9975;33.3115;43.4174;26.9979;7.63639;33.4848;21.8798;39.4215;9.6236;38.2987;0.978353;22.3101;41.1311;13.9582;55.9966;53.6991;27.1236;50.2978;83.8302 26.5474;18.2059;27.6952;86.0232;24.5771;126.828;206.18;94.9303;1.16694E-12;39.6721;46.6318;46.786;129.393;130.247;25.4349;109.049;40.5656;92.6554;98.3689;277.036;115.953;114.587;55.6613;327.378;45.0542;107.244;71.7388;99.5908;71.5977;17.0471;63.9031;73.8251;106.603;29.0958;94.4701;7.96997;38.3337;132.851;336.862;356.234;224.488;63.2034;197.161;129.44 25 19 25 29142;360847;360243;24825;78968;83792;287877;362282;287167;293502;24450;85430;360504;316033;171142;29740;24306;25086;29680;498709;297594;58919;25612;25649;81639 VNN1_10157;UBE2T_10125;TOP2A_10059;TF_10003;SREBF1_32750;SCD_9786;PYCR1_9631;PCK1_9439;LOC287167_9118;KIF22_8963;HMGCS2_8812;HERPUD1_8795;HBA2_32600;GLB1_8712;EHHADH_8534;ECI1_8520;CYP4A2_8425;CYP2E1_8421;CYP11A1_32785;CKS2_8325;CDCA3_8260;CCND1_8224;ASNS_8091;APOA2_33095;ALOX15_8036 49.1347428 49.5529 34.4791889891999 34.24606972 33.4848 25.112638747729022 82.28609480000001 71.5977 60.93236103758009 20.8684;10.9914;13.8391;51.412;11.2357;83.9984;54.7122;5.51457;105.203;13.2391;30.5985;53.893;101.406;65.9159;32.6956;103.231;59.5671;49.5529;43.719;14.4197;2.6193;28.2655;85.6642;80.183;105.624 17.1194;7.86591;9.31624;36.6131;4.94421;54.1928;38.3856;1.34064;82.0435;9.02099;24.577;37.9512;84.6435;47.8573;25.6436;49.9975;43.4174;26.9979;33.4848;9.6236;0.978353;22.3101;53.6991;50.2978;83.8302 26.5474;18.2059;27.6952;86.0232;24.5771;206.18;94.9303;39.6721;130.247;25.4349;40.5656;92.6554;115.953;114.587;45.0542;107.244;99.5908;71.5977;63.9031;29.0958;7.96997;38.3337;224.488;197.161;129.44 19 25044;29692;114519;286918;290350;24516;362376;24440;81660;24367;116663;499353;299691;84032;114851;24770;287562;791259;29657 SDS_9798;PLA2G2A_32641;NFIL3_9304;MX2_9268;LOXL2_9150;JUN_8938;HERC6_8794;HBB_8782;GATM_32792;FGG_8639;DUSP6_8506;CYP2C24_32875;CRY1_8386;COL3A1_8354;CDKN1A_8271;CCL2_8218;CCL12_8217;CAR14_8195;ARNTL_8086 50.5428736842106 53.833 26.310746460267605 32.856125789473744 36.3389 15.204482449212483 129.9982368421053 98.3689 110.02282377774165 64.7394;1.16694E-12;33.1149;31.6605;65.4434;57.7663;53.833;91.4283;37.423;93.1824;45.5478;10.5651;37.2548;57.8774;54.5478;64.0097;25.5289;98.1742;38.2177 43.4259;1.16694E-12;25.603;23.5989;43.7615;38.6865;36.3389;54.7263;28.03;51.338;33.3115;7.63639;21.8798;39.4215;38.2987;41.1311;13.9582;55.9966;27.1236 126.828;1.16694E-12;46.6318;46.786;129.393;109.049;98.3689;277.036;55.6613;327.378;71.7388;17.0471;73.8251;106.603;94.4701;132.851;336.862;356.234;63.2034 0 Exp 2,17(0.39);Exp 3,1(0.03);Exp 4,1(0.03);Hill,3(0.07);Linear,11(0.25);Poly 2,10(0.23);Power,1(0.03) 1.9549529246168156 88.93522524833679 1.5089621543884277 4.897102355957031 0.6152993330313719 1.8680987358093262 40.61724645808971 58.86835217827394 27.383031659592085 39.9087016585898 76.94223760897032 128.8358928455752 CONFLICT 0.5681818181818182 0.4318181818181818 0.0 GO:0010942 6 positive regulation of cell death 222 238 11 11 10 8 8 8 61 230 2248 0.80969 0.31406 0.52628 3.36 360243;24516;24440;360504;361921;116663;114851;24770 top2a;jun;hbb;hba-a2;ect2;dusp6;cdkn1a;ccl2 TOP2A_10059;JUN_8938;HBB_8782;HBA2_32600;ECT2_8523;DUSP6_8506;CDKN1A_8271;CCL2_8218 55.3699 56.15705 13.8391 31.621072988752303 52.036382976294206 23.639456875483823 38.71327375 38.492599999999996 9.31624 24.24109296823 35.93944556440225 16.888587966995004 107.35855000000001 101.75955 27.6952 78.6228365905043 99.41457279692337 63.778293464439066 13.8391;57.7663;91.4283;101.406;14.4142;45.5478;54.5478;64.0097 9.31624;38.6865;54.7263;84.6435;9.59235;33.3115;38.2987;41.1311 27.6952;109.049;277.036;115.953;30.0753;71.7388;94.4701;132.851 3 5 3 360243;360504;361921 TOP2A_10059;HBA2_32600;ECT2_8523 43.219766666666665 14.4142 50.39157664871515 34.517363333333336 9.59235 43.41072726904069 57.907833333333336 30.0753 50.28267344745438 13.8391;101.406;14.4142 9.31624;84.6435;9.59235 27.6952;115.953;30.0753 5 24516;24440;116663;114851;24770 JUN_8938;HBB_8782;DUSP6_8506;CDKN1A_8271;CCL2_8218 62.65998 57.7663 17.407040618295834 41.23082 38.6865 8.061086243925196 137.02898 109.049 81.35779974631812 57.7663;91.4283;45.5478;54.5478;64.0097 38.6865;54.7263;33.3115;38.2987;41.1311 109.049;277.036;71.7388;94.4701;132.851 0 Exp 2,2(0.25);Linear,3(0.38);Poly 2,3(0.38) 1.6858341184764505 13.522788047790527 1.5230457782745361 1.8943853378295898 0.13215931171221598 1.7099270224571228 33.45761436403332 77.28218563596668 21.915053353215225 55.511494146784784 52.87570390891794 161.84139609108206 DOWN 0.375 0.625 0.0 GO:0010639 7 negative regulation of organelle organization 85 89 3 3 2 3 2 2 67 87 2391 0.56355 0.70352 1.0 2.25 360243;306575 top2a;ckap2 TOP2A_10059;CKAP2_8324 12.980450000000001 12.980450000000001 12.1218 1.2143144753316344 13.0727148757764 1.2072837406325634 8.89334 8.89334 8.47044 0.5980709155275759 8.938782049689442 0.5946081568899355 24.53775 24.53775 21.3803 4.465308612514924 24.877028788819878 4.4394550129395025 13.8391;12.1218 9.31624;8.47044 27.6952;21.3803 2 0 2 360243;306575 TOP2A_10059;CKAP2_8324 12.980450000000001 12.980450000000001 1.2143144753316344 8.89334 8.89334 0.5980709155275759 24.53775 24.53775 4.465308612514924 13.8391;12.1218 9.31624;8.47044 27.6952;21.3803 0 0 Poly 2,2(1) 2.033721313880156 4.077691078186035 1.8943853378295898 2.1833057403564453 0.20429757584988642 2.0388455390930176 11.297496000000002 14.663404 8.064456 9.722224 18.349148 30.726352 UP 1.0 0.0 0.0 GO:0000278 4 mitotic cell cycle 41 47 4 4 3 3 2 2 67 45 2433 0.86713 0.36583 0.36583 4.26 291441;303575 ska1;kif18b SKA1_9829;KIF18B_32882 7.7987 7.7987 3.6768 5.82924688274566 7.725934072801125 5.828338481906982 4.734325 4.734325 1.12034 5.110946601212929 4.670525546008435 5.110150136717195 16.398600000000002 16.398600000000002 11.7489 6.575668800966182 16.316516559912515 6.574644081448585 11.9206;3.6768 8.34831;1.12034 21.0483;11.7489 2 0 2 291441;303575 SKA1_9829;KIF18B_32882 7.7987 7.7987 5.82924688274566 4.734325 4.734325 5.110946601212929 16.398600000000002 16.398600000000002 6.575668800966182 11.9206;3.6768 8.34831;1.12034 21.0483;11.7489 0 0 Exp 4,1(0.5);Poly 2,1(0.5) 1.8475289857870252 3.6953041553497314 1.8263249397277832 1.8689792156219482 0.030161127731365988 1.8476520776748657 -0.2802239999999987 15.877623999999999 -2.3490855999999987 11.817735599999999 7.285188000000003 25.512012 UP 1.0 0.0 0.0 GO:0022402 3 cell cycle process 177 191 14 14 13 11 10 10 59 181 2297 0.98783 0.030612 0.034888 5.24 360243;304477;293502;303575;361921;498709;306575;114851;58919;289054 top2a;kntc1;kif22;kif18b;ect2;cks2;ckap2;cdkn1a;ccnd1;aspm TOP2A_10059;KNTC1_8976;KIF22_8963;KIF18B_32882;ECT2_8523;CKS2_8325;CKAP2_8324;CDKN1A_8271;CCND1_8224;ASPM_8092 17.274589 13.539100000000001 3.6768 14.538050463727133 22.174132820152934 18.833621769240917 11.904844 9.168614999999999 1.12034 10.767496631335748 15.383606710870193 13.861775192899591 30.76644 26.56505 11.7489 23.87659171365219 38.04501902526376 31.691545981197166 8.5 41.40665 13.8391;7.89839;13.2391;3.6768;14.4142;14.4197;12.1218;54.5478;28.2655;10.3235 9.31624;3.83458;9.02099;1.12034;9.59235;9.6236;8.47044;38.2987;22.3101;7.4611 27.6952;12.5679;25.4349;11.7489;30.0753;29.0958;21.3803;94.4701;38.3337;16.8623 9 1 9 360243;304477;293502;303575;361921;498709;306575;58919;289054 TOP2A_10059;KNTC1_8976;KIF22_8963;KIF18B_32882;ECT2_8523;CKS2_8325;CKAP2_8324;CCND1_8224;ASPM_8092 13.133121111111112 13.2391 6.694551299845352 8.972193333333333 9.02099 5.803137722489014 23.688255555555557 25.4349 8.815909865707441 13.8391;7.89839;13.2391;3.6768;14.4142;14.4197;12.1218;28.2655;10.3235 9.31624;3.83458;9.02099;1.12034;9.59235;9.6236;8.47044;22.3101;7.4611 27.6952;12.5679;25.4349;11.7489;30.0753;29.0958;21.3803;38.3337;16.8623 1 114851 CDKN1A_8271 54.5478 54.5478 38.2987 38.2987 94.4701 94.4701 54.5478 38.2987 94.4701 0 Exp 4,1(0.1);Exp 5,1(0.1);Linear,2(0.2);Poly 2,6(0.6) 1.7893455268459713 18.045619249343872 1.530501127243042 2.2675669193267822 0.2538511874485086 1.7371234893798828 8.263811968046408 26.28536603195359 5.231080445570582 18.578607554429418 15.967575134899423 45.56530486510057 UP 0.9 0.1 0.0 GO:0045893 8 positive regulation of transcription, DNA-templated 299 321 16 16 14 15 13 13 56 308 2170 0.95505 0.085767 0.13775 4.05 360243;24825;78968;360918;362282;316351;114519;366960;24516;24309;306575;282840;29657 top2a;tf;srebf1;pf4;pck1;npas2;nfil3;maff;jun;dbp;ckap2;atf5;arntl TOP2A_10059;TF_10003;SREBF1_32750;PF4_32963;PCK1_9439;NPAS2_9350;NFIL3_9304;MAFF_9172;JUN_8938;DBP_8439;CKAP2_8324;ATF5_8097;ARNTL_8086 45.69186692307692 50.6952 5.51457 31.646462775383334 54.52582522349604 28.048822683074984 30.590186923076924 35.795 1.34064 21.10305652502476 37.919553165894385 20.572242198080875 69.73927692307691 63.2034 21.3803 35.69442013578954 82.2103846249101 31.559091484530434 13.8391;51.412;11.2357;105.82;5.51457;58.2312;33.1149;58.0695;57.7663;50.6952;12.1218;97.9563;38.2177 9.31624;36.6131;4.94421;53.8521;1.34064;35.795;25.603;40.1293;38.6865;40.5862;8.47044;75.2121;27.1236 27.6952;86.0232;24.5771;109.875;39.6721;99.4319;46.6318;104.733;109.049;59.5346;21.3803;114.804;63.2034 6 7 6 360243;24825;78968;362282;366960;306575 TOP2A_10059;TF_10003;SREBF1_32750;PCK1_9439;MAFF_9172;CKAP2_8324 25.365444999999998 12.980450000000001 23.021450583257128 16.802321666666668 8.89334 16.98090067943443 50.680150000000005 33.68365 35.665606113046785 13.8391;51.412;11.2357;5.51457;58.0695;12.1218 9.31624;36.6131;4.94421;1.34064;40.1293;8.47044 27.6952;86.0232;24.5771;39.6721;104.733;21.3803 7 360918;316351;114519;24516;24309;282840;29657 PF4_32963;NPAS2_9350;NFIL3_9304;JUN_8938;DBP_8439;ATF5_8097;ARNTL_8086 63.114514285714286 57.7663 28.17867480474249 42.40835714285714 38.6865 17.243344588454722 86.07567142857143 99.4319 28.522727301850306 105.82;58.2312;33.1149;57.7663;50.6952;97.9563;38.2177 53.8521;35.795;25.603;38.6865;40.5862;75.2121;27.1236 109.875;99.4319;46.6318;109.049;59.5346;114.804;63.2034 0 Exp 2,1(0.08);Exp 3,1(0.08);Hill,2(0.16);Linear,3(0.24);Poly 2,4(0.31);Power,2(0.16) 2.6093153829565927 37.146833300590515 1.5230457782745361 5.737884044647217 1.3782748684543327 2.3449018001556396 28.48865379396416 62.89508005218967 19.11843471960126 42.06193912655259 50.335569106678065 89.14298473947576 CONFLICT 0.46153846153846156 0.5384615384615384 0.0 GO:0006875 8 cellular metal ion homeostasis 132 139 5 4 4 5 4 4 65 135 2343 0.67668 0.52596 0.78842 2.88 24825;85430;24770;287562 tf;herpud1;ccl2;ccl12 TF_10003;HERPUD1_8795;CCL2_8218;CCL12_8217 48.710899999999995 52.6525 25.5289 16.38707322922555 41.20814428143712 17.87973389028923 32.4134 37.28215 13.9582 12.448526141140833 26.629701477045913 14.100937447497952 162.0979 112.75319999999999 86.0232 118.33214918857287 213.75090602794415 137.176901101331 51.412;53.893;64.0097;25.5289 36.6131;37.9512;41.1311;13.9582 86.0232;92.6554;132.851;336.862 2 2 2 24825;85430 TF_10003;HERPUD1_8795 52.6525 52.6525 1.7543319241234476 37.28215 37.28215 0.9461795839057369 89.33930000000001 89.33930000000001 4.689673594185197 51.412;53.893 36.6131;37.9512 86.0232;92.6554 2 24770;287562 CCL2_8218;CCL12_8217 44.7693 44.7693 27.210034625483285 27.54465 27.54465 19.214141854503943 234.8565 234.8565 144.2575615366488 64.0097;25.5289 41.1311;13.9582 132.851;336.862 0 Exp 2,1(0.25);Linear,2(0.5);Poly 2,1(0.25) 1.6445382692198633 6.6234060525894165 1.5270863771438599 2.0048909187316895 0.23314903927188077 1.5457143783569336 32.65156823535898 64.77023176464103 20.213844381681984 44.612955618318026 46.13239379519861 278.0634062048014 CONFLICT 0.5 0.5 0.0 GO:0071320 6 cellular response to cAMP 28 29 3 3 3 3 3 3 66 26 2452 0.99297 0.042049 0.042049 10.34 24825;362282;29680 tf;pck1;cyp11a1 TF_10003;PCK1_9439;CYP11A1_32785 33.54852333333333 43.719 5.51457 24.5809370625213 41.06583762519979 21.005241791291436 23.81284666666667 33.4848 1.34064 19.52425720929053 29.35981843100693 16.34127658447334 63.199466666666666 63.9031 39.6721 23.18355975046398 71.9774497469366 21.888280811547737 0.5 24.616785 1.5 47.5655 51.412;5.51457;43.719 36.6131;1.34064;33.4848 86.0232;39.6721;63.9031 3 0 3 24825;362282;29680 TF_10003;PCK1_9439;CYP11A1_32785 33.54852333333333 43.719 24.5809370625213 23.81284666666667 33.4848 19.52425720929053 63.199466666666666 63.9031 23.18355975046398 51.412;5.51457;43.719 36.6131;1.34064;33.4848 86.0232;39.6721;63.9031 0 0 Exp 2,1(0.34);Hill,1(0.34);Linear,1(0.34) 2.019822684374905 6.10256028175354 1.752767562866211 2.3449018001556396 0.29715218913038927 2.0048909187316895 5.7325744985726885 61.36447216809398 1.7190697618643611 45.90662357146898 36.964799119766525 89.43413421356681 UP 1.0 0.0 0.0 GO:0050679 7 positive regulation of epithelial cell proliferation 67 70 4 4 3 3 3 3 66 67 2411 0.88064 0.29437 0.43673 4.29 24516;58919;24770 jun;ccnd1;ccl2 JUN_8938;CCND1_8224;CCL2_8218 50.01383333333333 57.7663 28.2655 19.091556064745827 46.326548544096084 19.37747876372613 34.042566666666666 38.6865 22.3101 10.233870130763517 32.136075602262416 10.491144747217273 93.41123333333333 109.049 38.3337 49.160805623619865 83.3578932965575 48.94938793705916 57.7663;28.2655;64.0097 38.6865;22.3101;41.1311 109.049;38.3337;132.851 1 2 1 58919 CCND1_8224 28.2655 28.2655 22.3101 22.3101 38.3337 38.3337 28.2655 22.3101 38.3337 2 24516;24770 JUN_8938;CCL2_8218 60.888 60.888 4.41475047766004 39.9088 39.9088 1.7285932372889559 120.95 120.95 16.83055560580231 57.7663;64.0097 38.6865;41.1311 109.049;132.851 0 Exp 2,2(0.67);Linear,1(0.34) 1.7530562172294586 5.350576281547546 1.5230457782745361 2.2675669193267822 0.4195984457571779 1.559963583946228 28.409703868202847 71.61796279846382 22.46185242396463 45.6232809093687 37.78054478699677 149.04192187966987 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0014823 3 response to activity 61 66 3 3 3 3 3 3 66 63 2415 0.89848 0.26449 0.42386 4.55 362282;299691;24770 pck1;cry1;ccl2 PCK1_9439;CRY1_8386;CCL2_8218 35.59302333333333 37.2548 5.51457 29.2829504096946 39.68680107007062 19.654759499161177 21.450513333333333 21.8798 1.34064 19.89870327520197 23.875413655621948 13.514532173804678 82.11606666666667 73.8251 39.6721 47.13949456139016 83.02343696748663 34.605698370026346 5.51457;37.2548;64.0097 1.34064;21.8798;41.1311 39.6721;73.8251;132.851 1 2 1 362282 PCK1_9439 5.51457 5.51457 1.34064 1.34064 39.6721 39.6721 5.51457 1.34064 39.6721 2 299691;24770 CRY1_8386;CCL2_8218 50.63225 50.63225 18.918571219967966 31.505450000000003 31.505450000000003 13.612724776656584 103.33805000000001 103.33805000000001 41.737614155639015 37.2548;64.0097 21.8798;41.1311 73.8251;132.851 0 Exp 2,2(0.67);Hill,1(0.34) 1.8956528972484519 5.767112612724304 1.559963583946228 2.3449018001556396 0.3959079944731783 1.8622472286224365 2.4562455019942036 68.72980116467247 -1.0669891838928613 43.968015850559524 28.772706912682906 135.45942642065043 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0032496 5 response to lipopolysaccharide 176 189 9 9 8 7 7 7 62 182 2296 0.86478 0.24831 0.35079 3.7 84386;360918;362282;24516;24450;29680;24770 slpi;pf4;pck1;jun;hmgcs2;cyp11a1;ccl2 SLPI_9890;PF4_32963;PCK1_9439;JUN_8938;HMGCS2_8812;CYP11A1_32785;CCL2_8218 51.99248142857142 56.5193 5.51457 31.042963647452886 51.81252245392788 22.930662441679694 33.200520000000004 38.6865 1.34064 16.565851491732417 34.8180897008022 11.754348117154255 85.14625714285715 100.108 39.6721 36.94377206042795 86.96867217966323 34.6428263459199 56.5193;105.82;5.51457;57.7663;30.5985;43.719;64.0097 39.3315;53.8521;1.34064;38.6865;24.577;33.4848;41.1311 100.108;109.875;39.6721;109.049;40.5656;63.9031;132.851 3 4 3 362282;24450;29680 PCK1_9439;HMGCS2_8812;CYP11A1_32785 26.61069 30.5985 19.411892987375037 19.800813333333334 24.577 16.595804434631464 48.046933333333335 40.5656 13.739108471197563 5.51457;30.5985;43.719 1.34064;24.577;33.4848 39.6721;40.5656;63.9031 4 84386;360918;24516;24770 SLPI_9890;PF4_32963;JUN_8938;CCL2_8218 71.028825 60.888 23.42445203021478 43.2503 40.231300000000005 7.143165399177027 112.97075000000001 109.462 13.971858248517455 56.5193;105.82;57.7663;64.0097 39.3315;53.8521;38.6865;41.1311 100.108;109.875;109.049;132.851 0 Exp 2,4(0.58);Exp 3,1(0.15);Hill,1(0.15);Linear,1(0.15) 1.9188062451081622 13.971558213233948 1.5230457782745361 3.3687045574188232 0.667648811689579 1.752767562866211 28.995532133089352 74.9894307240535 20.928365475117335 45.47267452488266 57.77792780078353 112.51458648493077 CONFLICT 0.42857142857142855 0.5714285714285714 0.0 GO:2000112 7 regulation of cellular macromolecule biosynthetic process 538 577 22 22 20 21 19 19 50 558 1920 0.86927 0.19928 0.31074 3.29 360243;24825;78968;360918;362282;316351;114519;366960;290350;24516;24440;24309;299691;498709;306575;114851;58919;282840;29657 top2a;tf;srebf1;pf4;pck1;npas2;nfil3;maff;loxl2;jun;hbb;dbp;cry1;cks2;ckap2;cdkn1a;ccnd1;atf5;arntl TOP2A_10059;TF_10003;SREBF1_32750;PF4_32963;PCK1_9439;NPAS2_9350;NFIL3_9304;MAFF_9172;LOXL2_9150;JUN_8938;HBB_8782;DBP_8439;CRY1_8386;CKS2_8325;CKAP2_8324;CDKN1A_8271;CCND1_8224;ATF5_8097;ARNTL_8086 46.59756684210526 50.6952 5.51457 29.735482383490773 51.706384350562594 25.073085876036938 30.96170684210526 35.795 1.34064 19.351902699909854 35.35528369561651 17.822057818896905 81.5139105263158 73.8251 21.3803 58.90289076407307 87.55892878574777 46.863792500582996 13.8391;51.412;11.2357;105.82;5.51457;58.2312;33.1149;58.0695;65.4434;57.7663;91.4283;50.6952;37.2548;14.4197;12.1218;54.5478;28.2655;97.9563;38.2177 9.31624;36.6131;4.94421;53.8521;1.34064;35.795;25.603;40.1293;43.7615;38.6865;54.7263;40.5862;21.8798;9.6236;8.47044;38.2987;22.3101;75.2121;27.1236 27.6952;86.0232;24.5771;109.875;39.6721;99.4319;46.6318;104.733;129.393;109.049;277.036;59.5346;73.8251;29.0958;21.3803;94.4701;38.3337;114.804;63.2034 8 11 8 360243;24825;78968;362282;366960;498709;306575;58919 TOP2A_10059;TF_10003;SREBF1_32750;PCK1_9439;MAFF_9172;CKS2_8325;CKAP2_8324;CCND1_8224 24.35973375 14.1294 19.892798217473388 16.593453750000002 9.46992 14.751637196827572 46.4388 33.71475 31.246905883394504 13.8391;51.412;11.2357;5.51457;58.0695;14.4197;12.1218;28.2655 9.31624;36.6131;4.94421;1.34064;40.1293;9.6236;8.47044;22.3101 27.6952;86.0232;24.5771;39.6721;104.733;29.0958;21.3803;38.3337 11 360918;316351;114519;290350;24516;24440;24309;299691;114851;282840;29657 PF4_32963;NPAS2_9350;NFIL3_9304;LOXL2_9150;JUN_8938;HBB_8782;DBP_8439;CRY1_8386;CDKN1A_8271;ATF5_8097;ARNTL_8086 62.77053636363635 57.7663 25.123957372049222 41.411345454545454 38.6865 15.378351316793609 107.02308181818181 99.4319 62.142837711289296 105.82;58.2312;33.1149;65.4434;57.7663;91.4283;50.6952;37.2548;54.5478;97.9563;38.2177 53.8521;35.795;25.603;43.7615;38.6865;54.7263;40.5862;21.8798;38.2987;75.2121;27.1236 109.875;99.4319;46.6318;129.393;109.049;277.036;59.5346;73.8251;94.4701;114.804;63.2034 0 Exp 2,2(0.11);Exp 3,1(0.06);Hill,2(0.11);Linear,7(0.37);Poly 2,5(0.27);Power,2(0.11) 2.3162187980761715 47.964348793029785 1.5230457782745361 5.737884044647217 1.2400767896000342 2.0048909187316895 33.226863316618015 59.96827036759249 22.26003016110988 39.663383523100656 55.027940699310584 107.99988035332103 CONFLICT 0.42105263157894735 0.5789473684210527 0.0 GO:0008610 5 lipid biosynthetic process 109 122 8 8 7 7 6 6 63 116 2362 0.95543 0.10979 0.14205 4.92 78968;83792;24450;29680;25649;81639 srebf1;scd2;hmgcs2;cyp11a1;apoa2;alox15 SREBF1_32750;SCD_9786;HMGCS2_8812;CYP11A1_32785;APOA2_33095;ALOX15_8036 59.22643333333334 61.95100000000001 11.2357 36.24558387713829 69.58298042060646 33.19107170970036 41.88780166666667 41.8913 4.94421 27.26319530241487 49.04424217574177 25.195934063387856 110.30446666666667 96.67155 24.5771 79.33236623052828 132.86644510922727 76.43924669663502 11.2357;83.9984;30.5985;43.719;80.183;105.624 4.94421;54.1928;24.577;33.4848;50.2978;83.8302 24.5771;206.18;40.5656;63.9031;197.161;129.44 6 0 6 78968;83792;24450;29680;25649;81639 SREBF1_32750;SCD_9786;HMGCS2_8812;CYP11A1_32785;APOA2_33095;ALOX15_8036 59.22643333333334 61.95100000000001 36.24558387713829 41.88780166666667 41.8913 27.26319530241487 110.30446666666667 96.67155 79.33236623052828 11.2357;83.9984;30.5985;43.719;80.183;105.624 4.94421;54.1928;24.577;33.4848;50.2978;83.8302 24.5771;206.18;40.5656;63.9031;197.161;129.44 0 0 Exp 2,3(0.5);Hill,1(0.17);Linear,1(0.17);Poly 2,1(0.17) 2.173473065724566 13.515565752983093 1.6914535760879517 3.3687045574188232 0.6926378273524184 1.9226102828979492 30.22392593010906 88.22894073655762 20.07270203207181 63.70290130126153 46.82535299821677 173.78358033511657 UP 1.0 0.0 0.0 GO:0048584 5 positive regulation of response to stimulus 502 537 18 18 15 14 13 13 56 524 1954 0.38665 0.72402 0.76502 2.42 24825;29692;316351;24516;85430;24367;84032;24770;287562;289054;29657;29339;81639 tf;pla2g2a;npas2;jun;herpud1;fgg;col3a1;ccl2;ccl12;aspm;arntl;apcs;alox15 TF_10003;PLA2G2A_32641;NPAS2_9350;JUN_8938;HERPUD1_8795;FGG_8639;COL3A1_8354;CCL2_8218;CCL12_8217;ASPM_8092;ARNTL_8086;APCS_8057;ALOX15_8036 55.232315384615475 57.7663 1.16694E-12 32.29743141721541 57.61043301014806 32.717057571938525 36.292930769230864 37.9512 1.16694E-12 21.894883792619233 37.94312417102972 23.09062847068065 145.84463076923086 106.603 1.16694E-12 125.31976264842378 173.8769242033482 136.04938416081055 51.412;1.16694E-12;58.2312;57.7663;53.893;93.1824;57.8774;64.0097;25.5289;10.3235;38.2177;101.954;105.624 36.6131;1.16694E-12;35.795;38.6865;37.9512;51.338;39.4215;41.1311;13.9582;7.4611;27.1236;58.4986;83.8302 86.0232;1.16694E-12;99.4319;109.049;92.6554;327.378;106.603;132.851;336.862;16.8623;63.2034;395.621;129.44 4 9 4 24825;85430;289054;81639 TF_10003;HERPUD1_8795;ASPM_8092;ALOX15_8036 55.313125 52.6525 39.04051755201468 41.4639 37.28215 31.553991324183798 81.245225 89.33930000000001 46.97842947384647 51.412;53.893;10.3235;105.624 36.6131;37.9512;7.4611;83.8302 86.0232;92.6554;16.8623;129.44 9 29692;316351;24516;24367;84032;24770;287562;29657;29339 PLA2G2A_32641;NPAS2_9350;JUN_8938;FGG_8639;COL3A1_8354;CCL2_8218;CCL12_8217;ARNTL_8086;APCS_8057 55.19640000000013 57.8774 31.51381671505347 33.99472222222235 38.6865 18.066462631681244 174.55547777777792 109.049 140.41387435413708 1.16694E-12;58.2312;57.7663;93.1824;57.8774;64.0097;25.5289;38.2177;101.954 1.16694E-12;35.795;38.6865;51.338;39.4215;41.1311;13.9582;27.1236;58.4986 1.16694E-12;99.4319;109.049;327.378;106.603;132.851;336.862;63.2034;395.621 0 Exp 2,4(0.31);Hill,1(0.08);Linear,3(0.24);Poly 2,3(0.24);Power,2(0.16) 1.9701447225612132 28.212434768676758 1.5230457782745361 4.897102355957031 1.2061816425653267 1.6244933605194092 37.67523167080921 72.78939909842174 24.390736359858266 48.19512517860345 77.72003177589063 213.9692297625711 DOWN 0.3076923076923077 0.6923076923076923 0.0 GO:0051247 7 positive regulation of protein metabolic process 428 454 20 20 18 16 16 16 53 438 2040 0.90646 0.1536 0.26272 3.52 24825;78968;29692;24516;85430;24367;361921;299691;498709;114851;58919;24770;287562;29657;25649;81639 tf;srebf1;pla2g2a;jun;herpud1;fgg;ect2;cry1;cks2;cdkn1a;ccnd1;ccl2;ccl12;arntl;apoa2;alox15 TF_10003;SREBF1_32750;PLA2G2A_32641;JUN_8938;HERPUD1_8795;FGG_8639;ECT2_8523;CRY1_8386;CKS2_8325;CDKN1A_8271;CCND1_8224;CCL2_8218;CCL12_8217;ARNTL_8086;APOA2_33095;ALOX15_8036 45.62216875000008 44.81485 1.16694E-12 30.29301198311173 48.49347043929556 28.050956261231722 30.47365375000007 31.86835 1.16694E-12 21.426991173654947 32.81027394427757 20.94901247945183 110.31250625000007 89.33930000000001 1.16694E-12 99.76574167495545 124.98897464579649 100.612768981364 51.412;11.2357;1.16694E-12;57.7663;53.893;93.1824;14.4142;37.2548;14.4197;54.5478;28.2655;64.0097;25.5289;38.2177;80.183;105.624 36.6131;4.94421;1.16694E-12;38.6865;37.9512;51.338;9.59235;21.8798;9.6236;38.2987;22.3101;41.1311;13.9582;27.1236;50.2978;83.8302 86.0232;24.5771;1.16694E-12;109.049;92.6554;327.378;30.0753;73.8251;29.0958;94.4701;38.3337;132.851;336.862;63.2034;197.161;129.44 8 8 8 24825;78968;85430;361921;498709;58919;25649;81639 TF_10003;SREBF1_32750;HERPUD1_8795;ECT2_8523;CKS2_8325;CCND1_8224;APOA2_33095;ALOX15_8036 44.9308875 39.83875 34.483932490713805 31.895319999999998 29.4616 26.475068910546774 78.4201875 62.17845 61.224384493142175 51.412;11.2357;53.893;14.4142;14.4197;28.2655;80.183;105.624 36.6131;4.94421;37.9512;9.59235;9.6236;22.3101;50.2978;83.8302 86.0232;24.5771;92.6554;30.0753;29.0958;38.3337;197.161;129.44 8 29692;24516;24367;299691;114851;24770;287562;29657 PLA2G2A_32641;JUN_8938;FGG_8639;CRY1_8386;CDKN1A_8271;CCL2_8218;CCL12_8217;ARNTL_8086 46.313450000000145 46.38275 27.860267429492527 29.051987500000145 32.711149999999996 16.681453284534218 142.20482500000014 101.75955 123.51122069289013 1.16694E-12;57.7663;93.1824;37.2548;54.5478;64.0097;25.5289;38.2177 1.16694E-12;38.6865;51.338;21.8798;38.2987;41.1311;13.9582;27.1236 1.16694E-12;109.049;327.378;73.8251;94.4701;132.851;336.862;63.2034 0 Exp 2,4(0.25);Hill,2(0.13);Linear,5(0.32);Poly 2,4(0.25);Power,1(0.07) 1.9322955244261997 32.56558644771576 1.5230457782745361 4.897102355957031 0.8386171148046028 1.821009635925293 30.77859287827532 60.465744621724824 19.974428074909152 40.972879425090994 61.42729282927191 159.19771967072825 CONFLICT 0.5 0.5 0.0 GO:0032502 2 developmental process 992 1073 46 43 40 38 33 33 36 1040 1438 0.86314 0.19773 0.38705 3.08 360243;24825;78968;362282;338475;24587;366960;290350;24516;79438;24450;362376;24440;360504;81660;24367;361921;116663;170568;24309;24306;29680;84032;114851;58919;24770;287562;282840;289054;25612;29657;25649;81639 top2a;tf;srebf1;pck1;nrep;nefh;maff;loxl2;jun;igfals;hmgcs2;herc6;hbb;hba-a2;gatm;fgg;ect2;dusp6;dmbt1;dbp;cyp4a2;cyp11a1;col3a1;cdkn1a;ccnd1;ccl2;ccl12;atf5;aspm;asns;arntl;apoa2;alox15 TOP2A_10059;TF_10003;SREBF1_32750;PCK1_9439;NREP_9364;NEFH_33218;MAFF_9172;LOXL2_9150;JUN_8938;IGFALS_8880;HMGCS2_8812;HERC6_8794;HBB_8782;HBA2_32600;GATM_32792;FGG_8639;ECT2_8523;DUSP6_8506;DMBT1_32993;DBP_8439;CYP4A2_8425;CYP11A1_32785;COL3A1_8354;CDKN1A_8271;CCND1_8224;CCL2_8218;CCL12_8217;ATF5_8097;ASPM_8092;ASNS_8091;ARNTL_8086;APOA2_33095;ALOX15_8036 52.77521121212121 53.833 5.51457 28.49177595018252 54.892063952294 26.042857311083743 36.173998181818185 38.2987 1.34064 20.59184344177909 37.5593005239278 18.82256777480222 116.45493939393941 99.5908 16.8623 85.64062951550412 125.97193856044052 85.95865063662293 13.8391;51.412;11.2357;5.51457;36.861;79.3182;58.0695;65.4434;57.7663;70.3663;30.5985;53.833;91.4283;101.406;37.423;93.1824;14.4142;45.5478;21.7434;50.6952;59.5671;43.719;57.8774;54.5478;28.2655;64.0097;25.5289;97.9563;10.3235;85.6642;38.2177;80.183;105.624 9.31624;36.6131;4.94421;1.34064;28.0333;39.4261;40.1293;43.7615;38.6865;46.0459;24.577;36.3389;54.7263;84.6435;28.03;51.338;9.59235;33.3115;12.6557;40.5862;43.4174;33.4848;39.4215;38.2987;22.3101;41.1311;13.9582;75.2121;7.4611;53.6991;27.1236;50.2978;83.8302 27.6952;86.0232;24.5771;39.6721;53.5645;264.141;104.733;129.393;109.049;148.796;40.5656;98.3689;277.036;115.953;55.6613;327.378;30.0753;71.7388;160.485;59.5346;99.5908;63.9031;106.603;94.4701;38.3337;132.851;336.862;114.804;16.8623;224.488;63.2034;197.161;129.44 16 17 16 360243;24825;78968;362282;366960;24450;360504;361921;170568;24306;29680;58919;289054;25612;25649;81639 TOP2A_10059;TF_10003;SREBF1_32750;PCK1_9439;MAFF_9172;HMGCS2_8812;HBA2_32600;ECT2_8523;DMBT1_32993;CYP4A2_8425;CYP11A1_32785;CCND1_8224;ASPM_8092;ASNS_8091;APOA2_33095;ALOX15_8036 45.098704375 37.15875 33.67524678947095 32.39453375 29.030900000000003 26.19774548170838 87.4724 74.96315 64.50818941737556 13.8391;51.412;11.2357;5.51457;58.0695;30.5985;101.406;14.4142;21.7434;59.5671;43.719;28.2655;10.3235;85.6642;80.183;105.624 9.31624;36.6131;4.94421;1.34064;40.1293;24.577;84.6435;9.59235;12.6557;43.4174;33.4848;22.3101;7.4611;53.6991;50.2978;83.8302 27.6952;86.0232;24.5771;39.6721;104.733;40.5656;115.953;30.0753;160.485;99.5908;63.9031;38.3337;16.8623;224.488;197.161;129.44 17 338475;24587;290350;24516;79438;362376;24440;81660;24367;116663;24309;84032;114851;24770;287562;282840;29657 NREP_9364;NEFH_33218;LOXL2_9150;JUN_8938;IGFALS_8880;HERC6_8794;HBB_8782;GATM_32792;FGG_8639;DUSP6_8506;DBP_8439;COL3A1_8354;CDKN1A_8271;CCL2_8218;CCL12_8217;ATF5_8097;ARNTL_8086 60.00015882352941 57.7663 21.119318660827428 39.731141176470594 39.4215 13.300106551784568 143.73262352941177 109.049 95.58684981383115 36.861;79.3182;65.4434;57.7663;70.3663;53.833;91.4283;37.423;93.1824;45.5478;50.6952;57.8774;54.5478;64.0097;25.5289;97.9563;38.2177 28.0333;39.4261;43.7615;38.6865;46.0459;36.3389;54.7263;28.03;51.338;33.3115;40.5862;39.4215;38.2987;41.1311;13.9582;75.2121;27.1236 53.5645;264.141;129.393;109.049;148.796;98.3689;277.036;55.6613;327.378;71.7388;59.5346;106.603;94.4701;132.851;336.862;114.804;63.2034 0 Exp 2,11(0.34);Hill,2(0.07);Linear,10(0.31);Poly 2,9(0.28);Power,1(0.04) 1.9580864252206505 68.68203282356262 1.5089621543884277 5.737884044647217 0.9329491447077578 1.7671042680740356 43.05403933213272 62.496383092109696 29.14822169904103 43.19977466459535 87.23502411430593 145.67485467357284 CONFLICT 0.48484848484848486 0.5151515151515151 0.0 GO:0010817 4 regulation of hormone levels 159 176 6 6 6 6 6 6 63 170 2308 0.80407 0.34108 0.47372 3.41 78968;24367;499353;29680;299691;29657 srebf1;fgg;cyp2c24;cyp11a1;cry1;arntl SREBF1_32750;FGG_8639;CYP2C24_32875;CYP11A1_32785;CRY1_8386;ARNTL_8086 39.02911666666667 37.73625 10.5651 30.13653580924103 35.506585870335165 22.99982844927715 24.401133333333334 24.5017 4.94421 17.213397207347146 22.489638061365245 13.270717230667222 94.98896666666667 63.553250000000006 17.0471 116.15678281322475 76.57581573649479 85.28904767625936 11.2357;93.1824;10.5651;43.719;37.2548;38.2177 4.94421;51.338;7.63639;33.4848;21.8798;27.1236 24.5771;327.378;17.0471;63.9031;73.8251;63.2034 2 4 2 78968;29680 SREBF1_32750;CYP11A1_32785 27.47735 27.47735 22.969161705316978 19.214505 19.214505 20.18124472806497 44.2401 44.2401 27.807681276942187 11.2357;43.719 4.94421;33.4848 24.5771;63.9031 4 24367;499353;299691;29657 FGG_8639;CYP2C24_32875;CRY1_8386;ARNTL_8086 44.805 37.73625 34.7041862225102 26.9944475 24.5017 18.198161426465358 120.3634 68.51425 140.19317794355518 93.1824;10.5651;37.2548;38.2177 51.338;7.63639;21.8798;27.1236 327.378;17.0471;73.8251;63.2034 0 Exp 2,3(0.5);Hill,1(0.17);Poly 2,1(0.17);Power,1(0.17) 2.4176956183377243 15.569049954414368 1.752767562866211 4.897102355957031 1.1981825411340712 2.09975665807724 14.914865786400412 63.14336754693292 10.62754696670251 38.17471969996416 2.0441829684754538 187.93375036485787 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0010468 6 regulation of gene expression 723 775 28 28 24 24 22 22 47 753 1725 0.66004 0.44042 0.79156 2.84 360243;24825;78968;24777;360918;362282;316351;114519;366960;290350;24516;24440;24309;299691;498709;306575;114851;58919;24770;282840;29657;25649 top2a;tf;srebf1;slc10a1;pf4;pck1;npas2;nfil3;maff;loxl2;jun;hbb;dbp;cry1;cks2;ckap2;cdkn1a;ccnd1;ccl2;atf5;arntl;apoa2 TOP2A_10059;TF_10003;SREBF1_32750;SLC10A1_9832;PF4_32963;PCK1_9439;NPAS2_9350;NFIL3_9304;MAFF_9172;LOXL2_9150;JUN_8938;HBB_8782;DBP_8439;CRY1_8386;CKS2_8325;CKAP2_8324;CDKN1A_8271;CCND1_8224;CCL2_8218;ATF5_8097;ARNTL_8086;APOA2_33095 47.15973136363636 51.0536 5.51457 29.94603422672483 52.700750307010175 26.202460457706728 31.171662727272732 36.20405 1.34064 19.317642421797242 35.59640627045003 18.013156610351853 85.9210272727273 79.92415 11.4863 62.84456377049633 95.14521562663921 56.37981065830701 13.8391;51.412;11.2357;7.96762;105.82;5.51457;58.2312;33.1149;58.0695;65.4434;57.7663;91.4283;50.6952;37.2548;14.4197;12.1218;54.5478;28.2655;64.0097;97.9563;38.2177;80.183 9.31624;36.6131;4.94421;6.07525;53.8521;1.34064;35.795;25.603;40.1293;43.7615;38.6865;54.7263;40.5862;21.8798;9.6236;8.47044;38.2987;22.3101;41.1311;75.2121;27.1236;50.2978 27.6952;86.0232;24.5771;11.4863;109.875;39.6721;99.4319;46.6318;104.733;129.393;109.049;277.036;59.5346;73.8251;29.0958;21.3803;94.4701;38.3337;132.851;114.804;63.2034;197.161 9 13 9 360243;24825;78968;362282;366960;498709;306575;58919;25649 TOP2A_10059;TF_10003;SREBF1_32750;PCK1_9439;MAFF_9172;CKS2_8325;CKAP2_8324;CCND1_8224;APOA2_33095 30.562318888888893 14.4197 26.315519279551772 20.33838111111111 9.6236 17.7940939204125 63.185711111111104 38.3337 58.12447223197912 13.8391;51.412;11.2357;5.51457;58.0695;14.4197;12.1218;28.2655;80.183 9.31624;36.6131;4.94421;1.34064;40.1293;9.6236;8.47044;22.3101;50.2978 27.6952;86.0232;24.5771;39.6721;104.733;29.0958;21.3803;38.3337;197.161 13 24777;360918;316351;114519;290350;24516;24440;24309;299691;114851;24770;282840;29657 SLC10A1_9832;PF4_32963;NPAS2_9350;NFIL3_9304;LOXL2_9150;JUN_8938;HBB_8782;DBP_8439;CRY1_8386;CDKN1A_8271;CCL2_8218;ATF5_8097;ARNTL_8086 58.65024769230768 57.7663 27.532298283480998 38.67162692307692 38.6865 17.11742855129209 101.66086153846155 99.4319 63.270508232265946 7.96762;105.82;58.2312;33.1149;65.4434;57.7663;91.4283;50.6952;37.2548;54.5478;64.0097;97.9563;38.2177 6.07525;53.8521;35.795;25.603;43.7615;38.6865;54.7263;40.5862;21.8798;38.2987;41.1311;75.2121;27.1236 11.4863;109.875;99.4319;46.6318;129.393;109.049;277.036;59.5346;73.8251;94.4701;132.851;114.804;63.2034 0 Exp 2,3(0.14);Exp 3,1(0.05);Hill,2(0.1);Linear,8(0.37);Poly 2,6(0.28);Power,2(0.1) 2.2642553518559945 53.94851839542389 1.5230457782745361 5.737884044647217 1.1712175152025932 1.988080620765686 34.64608010330754 59.67338262396518 23.09933373012047 39.24399172442499 59.65995548347297 112.18209906198157 CONFLICT 0.4090909090909091 0.5909090909090909 0.0 GO:0071704 3 organic substance metabolic process 1263 1393 54 50 47 47 39 39 30 1354 1124 0.66596 0.4273 0.80696 2.8 29142;360847;360243;24825;78968;25044;83792;287877;29692;362282;114519;286918;290350;293502;24516;24450;85430;362376;24440;316033;81660;24367;171142;29740;116663;24306;25086;499353;29680;299691;84032;297594;58919;24770;287562;25612;29657;25649;81639 vnn1;ube2t;top2a;tf;srebf1;sds;scd2;pycr1;pla2g2a;pck1;nfil3;mx2;loxl2;kif22;jun;hmgcs2;herpud1;herc6;hbb;glb1;gatm;fgg;ehhadh;eci1;dusp6;cyp4a2;cyp2e1;cyp2c24;cyp11a1;cry1;col3a1;cdca3;ccnd1;ccl2;ccl12;asns;arntl;apoa2;alox15 VNN1_10157;UBE2T_10125;TOP2A_10059;TF_10003;SREBF1_32750;SDS_9798;SCD_9786;PYCR1_9631;PLA2G2A_32641;PCK1_9439;NFIL3_9304;MX2_9268;LOXL2_9150;KIF22_8963;JUN_8938;HMGCS2_8812;HERPUD1_8795;HERC6_8794;HBB_8782;GLB1_8712;GATM_32792;FGG_8639;EHHADH_8534;ECI1_8520;DUSP6_8506;CYP4A2_8425;CYP2E1_8421;CYP2C24_32875;CYP11A1_32785;CRY1_8386;COL3A1_8354;CDCA3_8260;CCND1_8224;CCL2_8218;CCL12_8217;ASNS_8091;ARNTL_8086;APOA2_33095;ALOX15_8036 46.53673000000003 45.5478 1.16694E-12 28.67758308242267 48.066008037468 26.45169363567892 31.020826487179527 33.3115 1.16694E-12 18.501347615094907 32.526383810114986 17.659451733269766 97.464588974359 73.8251 1.16694E-12 82.6860062702065 104.61120213317302 83.90924010924064 20.8684;10.9914;13.8391;51.412;11.2357;64.7394;83.9984;54.7122;1.16694E-12;5.51457;33.1149;31.6605;65.4434;13.2391;57.7663;30.5985;53.893;53.833;91.4283;65.9159;37.423;93.1824;32.6956;103.231;45.5478;59.5671;49.5529;10.5651;43.719;37.2548;57.8774;2.6193;28.2655;64.0097;25.5289;85.6642;38.2177;80.183;105.624 17.1194;7.86591;9.31624;36.6131;4.94421;43.4259;54.1928;38.3856;1.16694E-12;1.34064;25.603;23.5989;43.7615;9.02099;38.6865;24.577;37.9512;36.3389;54.7263;47.8573;28.03;51.338;25.6436;49.9975;33.3115;43.4174;26.9979;7.63639;33.4848;21.8798;39.4215;0.978353;22.3101;41.1311;13.9582;53.6991;27.1236;50.2978;83.8302 26.5474;18.2059;27.6952;86.0232;24.5771;126.828;206.18;94.9303;1.16694E-12;39.6721;46.6318;46.786;129.393;25.4349;109.049;40.5656;92.6554;98.3689;277.036;114.587;55.6613;327.378;45.0542;107.244;71.7388;99.5908;71.5977;17.0471;63.9031;73.8251;106.603;7.96997;38.3337;132.851;336.862;224.488;63.2034;197.161;129.44 22 17 22 29142;360847;360243;24825;78968;83792;287877;362282;293502;24450;85430;316033;171142;29740;24306;25086;29680;297594;58919;25612;25649;81639 VNN1_10157;UBE2T_10125;TOP2A_10059;TF_10003;SREBF1_32750;SCD_9786;PYCR1_9631;PCK1_9439;KIF22_8963;HMGCS2_8812;HERPUD1_8795;GLB1_8712;EHHADH_8534;ECI1_8520;CYP4A2_8425;CYP2E1_8421;CYP11A1_32785;CDCA3_8260;CCND1_8224;ASNS_8091;APOA2_33095;ALOX15_8036 45.78817590909091 46.63595 31.776069275129295 30.90187013636364 30.24135 21.22293110994745 80.99348045454548 67.7504 62.79459628854276 20.8684;10.9914;13.8391;51.412;11.2357;83.9984;54.7122;5.51457;13.2391;30.5985;53.893;65.9159;32.6956;103.231;59.5671;49.5529;43.719;2.6193;28.2655;85.6642;80.183;105.624 17.1194;7.86591;9.31624;36.6131;4.94421;54.1928;38.3856;1.34064;9.02099;24.577;37.9512;47.8573;25.6436;49.9975;43.4174;26.9979;33.4848;0.978353;22.3101;53.6991;50.2978;83.8302 26.5474;18.2059;27.6952;86.0232;24.5771;206.18;94.9303;39.6721;25.4349;40.5656;92.6554;114.587;45.0542;107.244;99.5908;71.5977;63.9031;7.96997;38.3337;224.488;197.161;129.44 17 25044;29692;114519;286918;290350;24516;362376;24440;81660;24367;116663;499353;299691;84032;24770;287562;29657 SDS_9798;PLA2G2A_32641;NFIL3_9304;MX2_9268;LOXL2_9150;JUN_8938;HERC6_8794;HBB_8782;GATM_32792;FGG_8639;DUSP6_8506;CYP2C24_32875;CRY1_8386;COL3A1_8354;CCL2_8218;CCL12_8217;ARNTL_8086 47.505447058823606 45.5478 25.023704783367695 31.174770000000073 33.3115 14.891297213479092 118.78014117647066 98.3689 101.02788788906905 64.7394;1.16694E-12;33.1149;31.6605;65.4434;57.7663;53.833;91.4283;37.423;93.1824;45.5478;10.5651;37.2548;57.8774;64.0097;25.5289;38.2177 43.4259;1.16694E-12;25.603;23.5989;43.7615;38.6865;36.3389;54.7263;28.03;51.338;33.3115;7.63639;21.8798;39.4215;41.1311;13.9582;27.1236 126.828;1.16694E-12;46.6318;46.786;129.393;109.049;98.3689;277.036;55.6613;327.378;71.7388;17.0471;73.8251;106.603;132.851;336.862;63.2034 0 Exp 2,16(0.42);Exp 3,1(0.03);Exp 4,1(0.03);Hill,3(0.08);Linear,10(0.26);Poly 2,7(0.18);Power,1(0.03) 2.0011349507804317 80.77303230762482 1.5089621543884277 4.897102355957031 0.636147921661273 1.9088982343673706 37.536236668222564 55.537223331777504 25.214156679617368 36.827496294741664 71.51348821641352 123.41568973230449 CONFLICT 0.5641025641025641 0.4358974358974359 0.0 GO:0007610 2 behavior 142 151 6 6 5 5 4 4 65 147 2331 0.61056 0.59321 1.0 2.65 316351;24516;81660;29680 npas2;jun;gatm;cyp11a1 NPAS2_9350;JUN_8938;GATM_32792;CYP11A1_32785 49.284875 50.74265 37.423 10.386759906526857 48.24025924538055 11.458971703888906 33.999075 34.6399 28.03 4.512635403970421 33.02718728087178 5.155635107411438 82.011325 81.6675 55.6613 26.183607676607544 80.46035455054486 27.458410978765688 58.2312;57.7663;37.423;43.719 35.795;38.6865;28.03;33.4848 99.4319;109.049;55.6613;63.9031 1 3 1 29680 CYP11A1_32785 43.719 43.719 33.4848 33.4848 63.9031 63.9031 43.719 33.4848 63.9031 3 316351;24516;81660 NPAS2_9350;JUN_8938;GATM_32792 51.140166666666666 57.7663 11.881688811921201 34.170500000000004 35.795 5.510852769762558 88.0474 99.4319 28.456401002410665 58.2312;57.7663;37.423 35.795;38.6865;28.03 99.4319;109.049;55.6613 0 Exp 2,3(0.75);Power,1(0.25) 2.302353935416746 10.280069828033447 1.5230457782745361 4.820915699005127 1.5253533828605703 1.968054175376892 39.1058502916037 59.4638997083963 29.576692304109056 38.42145769589095 56.35138947692464 107.67126052307539 DOWN 0.25 0.75 0.0 GO:0033043 6 regulation of organelle organization 271 282 9 9 8 9 8 8 61 274 2204 0.64686 0.50226 0.84579 2.84 360243;78968;291441;314654;361921;306575;282840;81639 top2a;srebf1;ska1;myo1f;ect2;ckap2;atf5;alox15 TOP2A_10059;SREBF1_32750;SKA1_9829;MYO1F_32715;ECT2_8523;CKAP2_8324;ATF5_8097;ALOX15_8036 44.8836625 14.12665 11.2357 44.571436325262894 64.90916536152525 45.58018747558607 32.60575625 9.454295 4.94421 34.353454645678006 48.66044260027709 35.83839498536054 59.9659 28.88525 21.0483 48.69609597293929 81.804132049083 49.645180516178584 13.8391;11.2357;11.9206;91.9576;14.4142;12.1218;97.9563;105.624 9.31624;4.94421;8.34831;61.1322;9.59235;8.47044;75.2121;83.8302 27.6952;24.5771;21.0483;110.707;30.0753;21.3803;114.804;129.44 7 1 7 360243;78968;291441;314654;361921;306575;81639 TOP2A_10059;SREBF1_32750;SKA1_9829;MYO1F_32715;ECT2_8523;CKAP2_8324;ALOX15_8036 37.301857142857145 13.8391 42.204263793597015 26.519135714285714 9.31624 32.11045973948098 52.131885714285715 27.6952 46.837215741737836 13.8391;11.2357;11.9206;91.9576;14.4142;12.1218;105.624 9.31624;4.94421;8.34831;61.1322;9.59235;8.47044;83.8302 27.6952;24.5771;21.0483;110.707;30.0753;21.3803;129.44 1 282840 ATF5_8097 97.9563 97.9563 75.2121 75.2121 114.804 114.804 97.9563 75.2121 114.804 0 Hill,1(0.13);Poly 2,7(0.88) 1.9900041085186626 16.205020546913147 1.5863633155822754 2.857419490814209 0.42571318817804943 1.8603551387786865 13.99723292463856 75.77009207536145 8.800026727599452 56.411485772400546 26.221227113819225 93.71057288618077 UP 0.875 0.125 0.0 GO:0051336 5 regulation of hydrolase activity 294 317 12 12 10 9 8 8 61 309 2169 0.50482 0.64197 1.0 2.52 84386;24516;85430;361921;24770;287562;25649;29339 slpi;jun;herpud1;ect2;ccl2;ccl12;apoa2;apcs SLPI_9890;JUN_8938;HERPUD1_8795;ECT2_8523;CCL2_8218;CCL12_8217;APOA2_33095;APCS_8057 56.78355 57.1428 14.4142 27.82990921472796 58.985358436463635 29.132494813884538 36.18090625 39.009 9.59235 16.656224658591015 37.021619232791394 17.449539903708754 174.2978375 120.95 30.0753 128.1064202884454 206.5393412602119 132.53382648183904 56.5193;57.7663;53.893;14.4142;64.0097;25.5289;80.183;101.954 39.3315;38.6865;37.9512;9.59235;41.1311;13.9582;50.2978;58.4986 100.108;109.049;92.6554;30.0753;132.851;336.862;197.161;395.621 3 5 3 85430;361921;25649 HERPUD1_8795;ECT2_8523;APOA2_33095 49.49673333333334 53.893 33.10406521582106 32.61378333333334 37.9512 20.871018840268274 106.63056666666667 92.6554 84.41496756288741 53.893;14.4142;80.183 37.9512;9.59235;50.2978 92.6554;30.0753;197.161 5 84386;24516;24770;287562;29339 SLPI_9890;JUN_8938;CCL2_8218;CCL12_8217;APCS_8057 61.155640000000005 57.7663 27.271320624568197 38.321180000000005 39.3315 15.88814753163502 214.8982 132.851 140.22168621044324 56.5193;57.7663;64.0097;25.5289;101.954 39.3315;38.6865;41.1311;13.9582;58.4986 100.108;109.049;132.851;336.862;395.621 0 Exp 2,2(0.25);Linear,4(0.5);Poly 2,2(0.25) 1.6311379367038368 13.099433183670044 1.5230457782745361 1.9712703227996826 0.15919544112677592 1.5711500644683838 37.49840682497069 76.06869317502932 24.638731433044832 47.72308106695517 85.52461737049624 263.0710576295038 DOWN 0.375 0.625 0.0 GO:2000179 7 positive regulation of neural precursor cell proliferation 15 17 2 2 2 2 2 2 67 15 2463 0.99014 0.075732 0.075732 11.76 24825;289054 tf;aspm TF_10003;ASPM_8092 30.86775 30.86775 10.3235 29.05395697878345 35.37156836441894 28.347198387241818 22.037100000000002 22.037100000000002 7.4611 20.613576885150234 25.23252725968436 20.112136665608965 51.442750000000004 51.442750000000004 16.8623 48.90414138296468 59.02365783357244 47.71451264806926 0.0 10.3235 0.5 30.86775 51.412;10.3235 36.6131;7.4611 86.0232;16.8623 2 0 2 24825;289054 TF_10003;ASPM_8092 30.86775 30.86775 29.05395697878345 22.037100000000002 22.037100000000002 20.613576885150234 51.442750000000004 51.442750000000004 48.90414138296468 51.412;10.3235 36.6131;7.4611 86.0232;16.8623 0 0 Linear,1(0.5);Poly 2,1(0.5) 1.7601490644991147 3.550174355506897 1.5452834367752075 2.0048909187316895 0.32499156717550215 1.7750871777534485 -9.398979999999987 71.13448 -6.531859999999995 50.60606 -16.334931999999995 119.220432 UP 1.0 0.0 0.0 GO:0044828 7 negative regulation by host of viral genome replication 3 3 1 1 1 1 1 1 68 2 2476 0.99787 0.07912 0.07912 33.33 287562 ccl12 CCL12_8217 25.5289 25.5289 25.5289 25.5289 13.9582 13.9582 13.9582 13.9582 336.862 336.862 336.862 336.862 0.0 25.5289 0.0 25.5289 25.5289 13.9582 336.862 0 1 0 1 287562 CCL12_8217 25.5289 25.5289 13.9582 13.9582 336.862 336.862 25.5289 13.9582 336.862 0 Poly 2,1(1) 1.5314651727676392 1.5314651727676392 1.5314651727676392 1.5314651727676392 0.0 1.5314651727676392 25.5289 25.5289 13.9582 13.9582 336.862 336.862 DOWN 0.0 1.0 0.0 GO:0050768 7 negative regulation of neurogenesis 70 74 3 3 3 3 3 3 66 71 2407 0.86153 0.32449 0.45163 4.05 84032;282840;289054 col3a1;atf5;aspm COL3A1_8354;ATF5_8097;ASPM_8092 55.38573333333333 57.8774 10.3235 43.86950206058116 73.54277892338845 44.81926700992758 40.69823333333334 39.4215 7.4611 33.89353974215932 55.82258489706379 34.96712413011087 79.42309999999999 106.603 16.8623 54.33419156231185 91.43961966756666 49.95384009163847 57.8774;97.9563;10.3235 39.4215;75.2121;7.4611 106.603;114.804;16.8623 1 2 1 289054 ASPM_8092 10.3235 10.3235 7.4611 7.4611 16.8623 16.8623 10.3235 7.4611 16.8623 2 84032;282840 COL3A1_8354;ATF5_8097 77.91685 77.91685 28.340061972497566 57.3168 57.3168 25.30777596273525 110.70349999999999 110.70349999999999 5.798982712511135 57.8774;97.9563 39.4215;75.2121 106.603;114.804 0 Exp 2,1(0.34);Poly 2,2(0.67) 1.8029239306622362 5.520756840705872 1.5452834367752075 2.385996103286743 0.4731442852872927 1.589477300643921 5.742718438506266 105.0287482281604 2.344082517240409 79.05238414942626 17.93817415558518 140.9080258444148 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:1901895 8 negative regulation of ATPase-coupled calcium transmembrane transporter activity 1 1 1 1 1 1 1 1 68 0 2478 1.0 0.027091 0.027091 100.0 100911740 mrln LOC100911740_32571 91.003 91.003 91.003 91.003 54.5666 54.5666 54.5666 54.5666 273.335 273.335 273.335 273.335 0.0 91.003 0.0 91.003 91.003 54.5666 273.335 0 1 0 1 100911740 LOC100911740_32571 91.003 91.003 54.5666 54.5666 273.335 273.335 91.003 54.5666 273.335 0 Linear,1(1) 1.8159936666488647 1.8159936666488647 1.8159936666488647 1.8159936666488647 0.0 1.8159936666488647 91.003 91.003 54.5666 54.5666 273.335 273.335 DOWN 0.0 1.0 0.0 GO:0006636 7 unsaturated fatty acid biosynthetic process 13 17 3 3 3 2 2 2 67 15 2463 0.99014 0.075732 0.075732 11.76 83792;81639 scd2;alox15 SCD_9786;ALOX15_8036 94.8112 94.8112 83.9984 15.291608407227729 96.14270864864864 15.175225109274333 69.0115 69.0115 54.1928 20.956806516738194 70.83630275337838 20.797305815959106 167.81 167.81 129.44 54.26337438825566 163.0850456081081 53.85037986856814 0.0 83.9984 0.5 94.8112 83.9984;105.624 54.1928;83.8302 206.18;129.44 2 0 2 83792;81639 SCD_9786;ALOX15_8036 94.8112 94.8112 15.291608407227729 69.0115 69.0115 20.956806516738194 167.81 167.81 54.26337438825566 83.9984;105.624 54.1928;83.8302 206.18;129.44 0 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.7803650861345364 3.5654038190841675 1.6914535760879517 1.8739502429962158 0.1290446307147762 1.7827019095420837 73.61811200000001 116.00428799999999 39.96684799999999 98.056152 92.6048 243.0152 UP 1.0 0.0 0.0 GO:0032879 4 regulation of localization 652 690 24 24 20 20 18 18 51 672 1806 0.4869 0.6214 1.0 2.61 24825;78968;24777;24587;314654;286918;58827;100911740;24516;24367;361921;299691;84032;24770;287562;29657;25649;81639 tf;srebf1;slc10a1;nefh;myo1f;mx2;mest;mrln;jun;fgg;ect2;cry1;col3a1;ccl2;ccl12;arntl;apoa2;alox15 TF_10003;SREBF1_32750;SLC10A1_9832;NEFH_33218;MYO1F_32715;MX2_9268;MEST_9219;LOC100911740_32571;JUN_8938;FGG_8639;ECT2_8523;CRY1_8386;COL3A1_8354;CCL2_8218;CCL12_8217;ARNTL_8086;APOA2_33095;ALOX15_8036 57.529456666666675 57.82185 7.96762 32.03359487550035 55.11626145304142 30.634543627590016 36.68615055555556 39.054 4.94421 21.223897968246423 35.42557204335304 21.112845771513097 147.49974444444445 109.878 11.4863 111.90157681058633 150.2094757649581 111.34290345822869 51.412;11.2357;7.96762;79.3182;91.9576;31.6605;96.9172;91.003;57.7663;93.1824;14.4142;37.2548;57.8774;64.0097;25.5289;38.2177;80.183;105.624 36.6131;4.94421;6.07525;39.4261;61.1322;23.5989;56.7353;54.5666;38.6865;51.338;9.59235;21.8798;39.4215;41.1311;13.9582;27.1236;50.2978;83.8302 86.0232;24.5771;11.4863;264.141;110.707;46.786;331.492;273.335;109.049;327.378;30.0753;73.8251;106.603;132.851;336.862;63.2034;197.161;129.44 6 12 6 24825;78968;314654;361921;25649;81639 TF_10003;SREBF1_32750;MYO1F_32715;ECT2_8523;APOA2_33095;ALOX15_8036 59.137750000000004 65.7975 40.08866690852915 41.06831 43.45545 30.43635312858622 96.3306 98.3651 64.98346688901722 51.412;11.2357;91.9576;14.4142;80.183;105.624 36.6131;4.94421;61.1322;9.59235;50.2978;83.8302 86.0232;24.5771;110.707;30.0753;197.161;129.44 12 24777;24587;286918;58827;100911740;24516;24367;299691;84032;24770;287562;29657 SLC10A1_9832;NEFH_33218;MX2_9268;MEST_9219;LOC100911740_32571;JUN_8938;FGG_8639;CRY1_8386;COL3A1_8354;CCL2_8218;CCL12_8217;ARNTL_8086 56.72531 57.82185 29.210497601626972 34.49507083333334 39.054 16.104848262168787 173.08431666666664 120.95 123.654423970654 7.96762;79.3182;31.6605;96.9172;91.003;57.7663;93.1824;37.2548;57.8774;64.0097;25.5289;38.2177 6.07525;39.4261;23.5989;56.7353;54.5666;38.6865;51.338;21.8798;39.4215;41.1311;13.9582;27.1236 11.4863;264.141;46.786;331.492;273.335;109.049;327.378;73.8251;106.603;132.851;336.862;63.2034 0 Exp 2,7(0.39);Hill,1(0.06);Linear,4(0.23);Poly 2,5(0.28);Power,1(0.06) 1.9841936250060737 37.457403898239136 1.5230457782745361 4.897102355957031 0.8002479269105258 1.8391204476356506 42.73069085399736 72.32822247933598 26.881209933537384 46.49109117757374 95.80385343613227 199.19563545275662 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:1901615 4 organic hydroxy compound metabolic process 134 145 9 9 8 8 7 7 62 138 2340 0.96029 0.094293 0.11085 4.83 78968;362282;24450;25086;29680;25649;81639 srebf1;pck1;hmgcs2;cyp2e1;cyp11a1;apoa2;alox15 SREBF1_32750;PCK1_9439;HMGCS2_8812;CYP2E1_8421;CYP11A1_32785;APOA2_33095;ALOX15_8036 46.63252428571429 43.719 5.51457 36.10945655141409 62.21589133867045 35.636796268763966 32.210364285714284 26.9979 1.34064 28.211132665240427 43.87611043136062 27.909999769128547 80.98808571428572 63.9031 24.5771 61.572447069053766 109.98893571139037 71.08365001674227 11.2357;5.51457;30.5985;49.5529;43.719;80.183;105.624 4.94421;1.34064;24.577;26.9979;33.4848;50.2978;83.8302 24.5771;39.6721;40.5656;71.5977;63.9031;197.161;129.44 7 0 7 78968;362282;24450;25086;29680;25649;81639 SREBF1_32750;PCK1_9439;HMGCS2_8812;CYP2E1_8421;CYP11A1_32785;APOA2_33095;ALOX15_8036 46.63252428571429 43.719 36.10945655141409 32.210364285714284 26.9979 28.211132665240427 80.98808571428572 63.9031 61.572447069053766 11.2357;5.51457;30.5985;49.5529;43.719;80.183;105.624 4.94421;1.34064;24.577;26.9979;33.4848;50.2978;83.8302 24.5771;39.6721;40.5656;71.5977;63.9031;197.161;129.44 0 0 Exp 2,2(0.29);Hill,2(0.29);Linear,1(0.15);Poly 2,2(0.29) 2.2486244796163324 16.19008481502533 1.6914535760879517 3.3687045574188232 0.6111270031256786 2.2035675048828125 19.882264522148844 73.38278404927972 11.311264739724745 53.109463831703835 35.37457859793256 126.60159283063888 UP 1.0 0.0 0.0 GO:0007160 5 cell-matrix adhesion 28 28 2 2 2 2 2 2 67 26 2452 0.96157 0.17463 0.17463 7.14 24367;84032 fgg;col3a1 FGG_8639;COL3A1_8354 75.5299 75.5299 57.8774 24.964404909791103 80.20862974537037 24.071570128256553 45.37975 45.37975 39.4215 8.426237958009448 46.95896209490741 8.124879349479322 216.9905 216.9905 106.603 156.11149961646 246.24829803240738 150.52827914079705 0.5 75.5299 93.1824;57.8774 51.338;39.4215 327.378;106.603 0 2 0 2 24367;84032 FGG_8639;COL3A1_8354 75.5299 75.5299 24.964404909791103 45.37975 45.37975 8.426237958009448 216.9905 216.9905 156.11149961646 93.1824;57.8774 51.338;39.4215 327.378;106.603 0 Exp 2,2(1) 1.7418812854974346 3.4983755350112915 1.589477300643921 1.9088982343673706 0.22586470828879004 1.7491877675056458 40.931000000000004 110.12879999999998 33.70158000000001 57.057919999999996 0.6310000000000571 433.3499999999999 DOWN 0.0 1.0 0.0 GO:0071407 6 cellular response to organic cyclic compound 197 209 9 9 8 8 7 7 62 202 2276 0.79922 0.33615 0.50458 3.35 24825;362282;24587;79438;24450;29680;24770 tf;pck1;nefh;igfals;hmgcs2;cyp11a1;ccl2 TF_10003;PCK1_9439;NEFH_33218;IGFALS_8880;HMGCS2_8812;CYP11A1_32785;CCL2_8218 49.27689571428571 51.412 5.51457 25.376402923118608 56.85067347402177 22.680162734391885 31.80266285714286 36.6131 1.34064 15.02287849056644 35.555985669214834 11.184469376129135 110.85028571428572 86.0232 39.6721 79.84218323986445 135.4684256186836 90.58853231008771 51.412;5.51457;79.3182;70.3663;30.5985;43.719;64.0097 36.6131;1.34064;39.4261;46.0459;24.577;33.4848;41.1311 86.0232;39.6721;264.141;148.796;40.5656;63.9031;132.851 4 3 4 24825;362282;24450;29680 TF_10003;PCK1_9439;HMGCS2_8812;CYP11A1_32785 32.8110175 37.15875 20.124379178777794 24.003885 29.030900000000003 15.94606729872813 57.541000000000004 52.234350000000006 22.054280201508874 51.412;5.51457;30.5985;43.719 36.6131;1.34064;24.577;33.4848 86.0232;39.6721;40.5656;63.9031 3 24587;79438;24770 NEFH_33218;IGFALS_8880;CCL2_8218 71.2314 70.3663 7.690828405965331 42.201033333333335 41.1311 3.4371508569356846 181.92933333333335 148.796 71.64237125007331 79.3182;70.3663;64.0097 39.4261;46.0459;41.1311 264.141;148.796;132.851 0 Exp 2,4(0.58);Hill,1(0.15);Linear,2(0.29) 1.9742291105232828 14.325911283493042 1.527578592300415 3.3687045574188232 0.6467015860803087 1.7671042680740356 30.477793349181297 68.07599807939012 20.6735587276764 42.93176698660931 51.702368638449116 169.9982027901223 CONFLICT 0.5714285714285714 0.42857142857142855 0.0 GO:0071902 9 positive regulation of protein serine/threonine kinase activity 93 101 3 3 3 3 3 3 66 98 2380 0.70829 0.52118 0.75299 2.97 24825;498709;58919 tf;cks2;ccnd1 TF_10003;CKS2_8325;CCND1_8224 31.365733333333335 28.2655 14.4197 18.690001333957497 33.258858331389476 16.829149257001227 22.848933333333335 22.3101 9.6236 13.50281576499262 24.603951527874973 11.82203306801238 51.1509 38.3337 29.0958 30.55147589839156 52.318713762537904 29.29553362942518 51.412;14.4197;28.2655 36.6131;9.6236;22.3101 86.0232;29.0958;38.3337 3 0 3 24825;498709;58919 TF_10003;CKS2_8325;CCND1_8224 31.365733333333335 28.2655 18.690001333957497 22.848933333333335 22.3101 13.50281576499262 51.1509 38.3337 30.55147589839156 51.412;14.4197;28.2655 36.6131;9.6236;22.3101 86.0232;29.0958;38.3337 0 0 Linear,2(0.67);Poly 2,1(0.34) 1.9090977759487826 5.802958965301514 1.530501127243042 2.2675669193267822 0.37356622291487285 2.0048909187316895 10.216005822756259 52.515460843910404 7.5690588725299595 38.128807794136705 16.57865044520961 85.72314955479038 UP 1.0 0.0 0.0 GO:0009266 4 response to temperature stimulus 80 87 5 5 4 3 3 3 66 84 2394 0.79201 0.42179 0.50972 3.45 24450;114851;24770 hmgcs2;cdkn1a;ccl2 HMGCS2_8812;CDKN1A_8271;CCL2_8218 49.71866666666667 54.5478 30.5985 17.221134339042028 47.55155690214607 15.925739557040277 34.668933333333335 38.2987 24.577 8.853867022004188 33.87685642966927 8.538966252537143 89.29556666666667 94.4701 40.5656 46.3597951861668 81.4510497637616 40.580584392674396 30.5985;54.5478;64.0097 24.577;38.2987;41.1311 40.5656;94.4701;132.851 1 2 1 24450 HMGCS2_8812 30.5985 30.5985 24.577 24.577 40.5656 40.5656 30.5985 24.577 40.5656 2 114851;24770 CDKN1A_8271;CCL2_8218 59.27875 59.27875 6.690573652908962 39.7149 39.7149 2.0028092470327894 113.66055 113.66055 27.139394658042768 54.5478;64.0097 38.2987;41.1311 94.4701;132.851 0 Exp 2,2(0.67);Linear,1(0.34) 2.060428671388353 6.5932124853134155 1.559963583946228 3.3687045574188232 1.0154344782453877 1.6645443439483643 30.231118635729256 69.20621469760407 24.649839616627727 44.68802705003894 36.83451981526042 141.75661351807292 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0030968 5 endoplasmic reticulum unfolded protein response 19 20 2 2 2 2 2 2 67 18 2460 0.98441 0.1005 0.1005 10.0 85430;58919 herpud1;ccnd1 HERPUD1_8795;CCND1_8224 41.07925 41.07925 28.2655 18.12137903485824 37.383647400964165 17.351352137081385 30.13065 30.13065 22.3101 11.059927875216912 27.87513191154894 10.58996132714091 65.49455 65.49455 38.3337 38.411242435581265 57.66111264933976 36.77904381562363 0.0 28.2655 1.0 53.893 53.893;28.2655 37.9512;22.3101 92.6554;38.3337 2 0 2 85430;58919 HERPUD1_8795;CCND1_8224 41.07925 41.07925 18.12137903485824 30.13065 30.13065 11.059927875216912 65.49455 65.49455 38.411242435581265 53.893;28.2655 37.9512;22.3101 92.6554;38.3337 0 0 Linear,2(1) 1.8608521036788495 3.794653296470642 1.5270863771438599 2.2675669193267822 0.5235988127142358 1.897326648235321 15.964300000000005 66.1942 14.802372 45.458928 12.259284000000008 118.729816 UP 1.0 0.0 0.0 GO:0048511 2 rhythmic process 111 122 11 11 10 10 9 9 60 113 2365 0.99865 0.0048973 0.0048973 7.38 360243;78968;316351;114519;24516;24309;299691;282840;29657 top2a;srebf1;npas2;nfil3;jun;dbp;cry1;atf5;arntl TOP2A_10059;SREBF1_32750;NPAS2_9350;NFIL3_9304;JUN_8938;DBP_8439;CRY1_8386;ATF5_8097;ARNTL_8086 44.256800000000005 38.2177 11.2357 26.28723532282352 51.73098024827707 26.083653007897503 31.016294444444448 27.1236 4.94421 20.630980068762558 36.08791076272309 21.163790370510316 68.75023333333333 63.2034 24.5771 33.45474701283065 80.03597917697472 29.39795804944333 5.5 54.23075 13.8391;11.2357;58.2312;33.1149;57.7663;50.6952;37.2548;97.9563;38.2177 9.31624;4.94421;35.795;25.603;38.6865;40.5862;21.8798;75.2121;27.1236 27.6952;24.5771;99.4319;46.6318;109.049;59.5346;73.8251;114.804;63.2034 2 7 2 360243;78968 TOP2A_10059;SREBF1_32750 12.5374 12.5374 1.840881794141057 7.130225 7.130225 3.0914920605510208 26.13615 26.13615 2.2048296544177473 13.8391;11.2357 9.31624;4.94421 27.6952;24.5771 7 316351;114519;24516;24309;299691;282840;29657 NPAS2_9350;NFIL3_9304;JUN_8938;DBP_8439;CRY1_8386;ATF5_8097;ARNTL_8086 53.31948571428571 50.6952 22.126885992492543 37.84088571428571 35.795 17.927759836859035 80.9256857142857 73.8251 26.706078666003446 58.2312;33.1149;57.7663;50.6952;37.2548;97.9563;38.2177 35.795;25.603;38.6865;40.5862;21.8798;75.2121;27.1236 99.4319;46.6318;109.049;59.5346;73.8251;114.804;63.2034 0 Exp 2,2(0.23);Hill,1(0.12);Linear,1(0.12);Poly 2,3(0.34);Power,2(0.23) 2.8901763855558626 28.814539432525635 1.5230457782745361 5.737884044647217 1.5478830704183997 2.835543394088745 27.08247292242198 61.431127077578026 17.53738746618624 44.49520142270265 46.893131951617335 90.60733471504935 DOWN 0.2222222222222222 0.7777777777777778 0.0 GO:0031326 6 regulation of cellular biosynthetic process 611 656 24 24 22 22 20 20 49 636 1842 0.77947 0.30909 0.57653 3.05 360243;24825;78968;360918;362282;316351;114519;366960;290350;24516;24440;24309;299691;498709;306575;114851;58919;282840;29657;25649 top2a;tf;srebf1;pf4;pck1;npas2;nfil3;maff;loxl2;jun;hbb;dbp;cry1;cks2;ckap2;cdkn1a;ccnd1;atf5;arntl;apoa2 TOP2A_10059;TF_10003;SREBF1_32750;PF4_32963;PCK1_9439;NPAS2_9350;NFIL3_9304;MAFF_9172;LOXL2_9150;JUN_8938;HBB_8782;DBP_8439;CRY1_8386;CKS2_8325;CKAP2_8324;CDKN1A_8271;CCND1_8224;ATF5_8097;ARNTL_8086;APOA2_33095 48.2768385 51.0536 5.51457 29.90085607012762 54.351041601084475 25.310232044278898 31.928511500000003 36.20405 1.34064 19.325631683830313 36.743013002073255 17.525116864833155 87.29626500000002 79.92415 21.3803 62.893998778690886 97.73780382754771 55.24501375518204 13.8391;51.412;11.2357;105.82;5.51457;58.2312;33.1149;58.0695;65.4434;57.7663;91.4283;50.6952;37.2548;14.4197;12.1218;54.5478;28.2655;97.9563;38.2177;80.183 9.31624;36.6131;4.94421;53.8521;1.34064;35.795;25.603;40.1293;43.7615;38.6865;54.7263;40.5862;21.8798;9.6236;8.47044;38.2987;22.3101;75.2121;27.1236;50.2978 27.6952;86.0232;24.5771;109.875;39.6721;99.4319;46.6318;104.733;129.393;109.049;277.036;59.5346;73.8251;29.0958;21.3803;94.4701;38.3337;114.804;63.2034;197.161 9 11 9 360243;24825;78968;362282;366960;498709;306575;58919;25649 TOP2A_10059;TF_10003;SREBF1_32750;PCK1_9439;MAFF_9172;CKS2_8325;CKAP2_8324;CCND1_8224;APOA2_33095 30.562318888888893 14.4197 26.315519279551772 20.33838111111111 9.6236 17.7940939204125 63.185711111111104 38.3337 58.12447223197912 13.8391;51.412;11.2357;5.51457;58.0695;14.4197;12.1218;28.2655;80.183 9.31624;36.6131;4.94421;1.34064;40.1293;9.6236;8.47044;22.3101;50.2978 27.6952;86.0232;24.5771;39.6721;104.733;29.0958;21.3803;38.3337;197.161 11 360918;316351;114519;290350;24516;24440;24309;299691;114851;282840;29657 PF4_32963;NPAS2_9350;NFIL3_9304;LOXL2_9150;JUN_8938;HBB_8782;DBP_8439;CRY1_8386;CDKN1A_8271;ATF5_8097;ARNTL_8086 62.77053636363635 57.7663 25.123957372049222 41.411345454545454 38.6865 15.378351316793609 107.02308181818181 99.4319 62.142837711289296 105.82;58.2312;33.1149;65.4434;57.7663;91.4283;50.6952;37.2548;54.5478;97.9563;38.2177 53.8521;35.795;25.603;43.7615;38.6865;54.7263;40.5862;21.8798;38.2987;75.2121;27.1236 109.875;99.4319;46.6318;129.393;109.049;277.036;59.5346;73.8251;94.4701;114.804;63.2034 0 Exp 2,2(0.1);Exp 3,1(0.05);Hill,2(0.1);Linear,8(0.4);Poly 2,5(0.25);Power,2(0.1) 2.2976184609122576 49.93561911582947 1.5230457782745361 5.737884044647217 1.2133234963940343 1.988080620765686 35.17221053538445 61.38146646461553 23.458679973979017 40.398343026020996 59.731754697395466 114.86077530260457 CONFLICT 0.45 0.55 0.0 GO:0002526 6 acute inflammatory response 39 43 3 3 3 3 3 3 66 40 2438 0.9725 0.10897 0.10897 6.98 29142;24825;25649 vnn1;tf;apoa2 VNN1_10157;TF_10003;APOA2_33095 50.821133333333336 51.412 20.8684 29.66171414219572 63.225407544456075 26.6691882272893 34.67676666666667 36.6131 17.1194 16.6737397341848 41.48145905465481 14.526567256950678 103.24386666666668 86.0232 26.5474 86.6005984192565 140.50022885721756 83.25106641931231 1.5 65.7975 20.8684;51.412;80.183 17.1194;36.6131;50.2978 26.5474;86.0232;197.161 3 0 3 29142;24825;25649 VNN1_10157;TF_10003;APOA2_33095 50.821133333333336 51.412 29.66171414219572 34.67676666666667 36.6131 16.6737397341848 103.24386666666668 86.0232 86.6005984192565 20.8684;51.412;80.183 17.1194;36.6131;50.2978 26.5474;86.0232;197.161 0 0 Exp 2,1(0.34);Linear,2(0.67) 2.1857641714802436 6.61840558052063 1.9712703227996826 2.642244338989258 0.3780555199937376 2.0048909187316895 17.255743989873373 84.3865226767933 15.808653943765115 53.544879389568216 5.246064200359427 201.2416691329739 UP 1.0 0.0 0.0 GO:1903522 6 regulation of blood circulation 63 68 3 3 3 2 2 2 67 66 2412 0.72061 0.55624 0.70687 2.94 78968;24367 srebf1;fgg SREBF1_32750;FGG_8639 52.20905 52.20905 11.2357 57.94506726585967 54.30746874248618 57.86902537633899 28.141105 28.141105 4.94421 32.805363513944634 29.32911621303198 32.76231270831579 175.97755 175.97755 24.5771 214.1125697393896 183.73140810290934 213.83158767928768 11.2357;93.1824 4.94421;51.338 24.5771;327.378 1 1 1 78968 SREBF1_32750 11.2357 11.2357 4.94421 4.94421 24.5771 24.5771 11.2357 4.94421 24.5771 1 24367 FGG_8639 93.1824 93.1824 51.338 51.338 327.378 327.378 93.1824 51.338 327.378 0 Exp 2,1(0.5);Hill,1(0.5) 2.335492029714971 4.76631772518158 1.9088982343673706 2.857419490814209 0.6707058125331437 2.38315886259079 -28.098715999999982 132.516816 -17.324809199999997 73.6070192 -120.76733199999993 472.7224319999999 CONFLICT 0.5 0.5 0.0 GO:0045444 5 fat cell differentiation 31 34 4 4 4 3 3 3 66 31 2447 0.9876 0.062612 0.062612 8.82 78968;58919;282840 srebf1;ccnd1;atf5 SREBF1_32750;CCND1_8224;ATF5_8097 45.81916666666666 28.2655 11.2357 45.94794909648672 60.443685557849946 45.65221573972954 34.15547 22.3101 4.94421 36.60093829522271 46.18843809085789 35.574349712213014 59.23826666666667 38.3337 24.5771 48.61043150953645 74.25080509354858 49.139485737228924 0.5 19.7506 11.2357;28.2655;97.9563 4.94421;22.3101;75.2121 24.5771;38.3337;114.804 2 1 2 78968;58919 SREBF1_32750;CCND1_8224 19.7506 19.7506 12.04188706225067 13.627154999999998 13.627154999999998 12.279538580339652 31.4554 31.4554 9.727385146070851 11.2357;28.2655 4.94421;22.3101 24.5771;38.3337 1 282840 ATF5_8097 97.9563 97.9563 75.2121 75.2121 114.804 114.804 97.9563 75.2121 114.804 0 Hill,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 2.49115804918877 7.510982513427734 2.2675669193267822 2.857419490814209 0.3120340627804448 2.385996103286743 -6.175832461286269 97.81416579461961 -7.262390691585843 75.57333069158585 4.230385060455383 114.24614827287795 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0006631 6 fatty acid metabolic process 129 145 9 9 9 8 8 8 61 137 2341 0.98522 0.039715 0.05627 5.52 83792;362282;171142;29740;24306;25086;499353;81639 scd2;pck1;ehhadh;eci1;cyp4a2;cyp2e1;cyp2c24;alox15 SCD_9786;PCK1_9439;EHHADH_8534;ECI1_8520;CYP4A2_8425;CYP2E1_8421;CYP2C24_32875;ALOX15_8036 56.34358375000001 54.56 5.51457 39.072767062949865 64.16051035828627 37.39489366291401 36.632053750000004 35.20765 1.34064 26.887374441650348 43.698855008149486 27.222617943792226 89.4782375 85.59425 17.0471 60.5383701365609 100.65760101286453 62.06634607025352 6.5 104.4275 83.9984;5.51457;32.6956;103.231;59.5671;49.5529;10.5651;105.624 54.1928;1.34064;25.6436;49.9975;43.4174;26.9979;7.63639;83.8302 206.18;39.6721;45.0542;107.244;99.5908;71.5977;17.0471;129.44 7 1 7 83792;362282;171142;29740;24306;25086;81639 SCD_9786;PCK1_9439;EHHADH_8534;ECI1_8520;CYP4A2_8425;CYP2E1_8421;ALOX15_8036 62.883367142857146 59.5671 37.17462606729968 40.77429142857143 43.4174 26.13956414886281 99.82554285714286 99.5908 57.2400253827645 83.9984;5.51457;32.6956;103.231;59.5671;49.5529;105.624 54.1928;1.34064;25.6436;49.9975;43.4174;26.9979;83.8302 206.18;39.6721;45.0542;107.244;99.5908;71.5977;129.44 1 499353 CYP2C24_32875 10.5651 10.5651 7.63639 7.63639 17.0471 17.0471 10.5651 7.63639 17.0471 0 Exp 2,3(0.38);Exp 3,1(0.13);Hill,1(0.13);Poly 2,3(0.38) 1.952334184472867 15.753216862678528 1.618504285812378 2.3449018001556396 0.276522285765789 1.894513189792633 29.267537571064445 83.41962992893556 18.000053849927028 55.26405365007297 47.52728729536748 131.42918770463254 UP 0.875 0.125 0.0 GO:0051409 4 response to nitrosative stress 5 5 1 1 1 1 1 1 68 4 2474 0.99314 0.12841 0.12841 20.0 116663 dusp6 DUSP6_8506 45.5478 45.5478 45.5478 45.5478 33.3115 33.3115 33.3115 33.3115 71.7388 71.7388 71.7388 71.7388 0.0 45.5478 0.0 45.5478 45.5478 33.3115 71.7388 0 1 0 1 116663 DUSP6_8506 45.5478 45.5478 33.3115 33.3115 71.7388 71.7388 45.5478 33.3115 71.7388 0 Linear,1(1) 1.5676488876342773 1.5676488876342773 1.5676488876342773 1.5676488876342773 0.0 1.5676488876342773 45.5478 45.5478 33.3115 33.3115 71.7388 71.7388 DOWN 0.0 1.0 0.0 GO:0006996 5 organelle organization 397 425 14 14 13 11 10 10 59 415 2063 0.38208 0.7385 0.74395 2.35 360243;24587;286918;293502;303575;24516;498709;24770;287562;289054 top2a;nefh;mx2;kif22;kif18b;jun;cks2;ccl2;ccl12;aspm TOP2A_10059;NEFH_33218;MX2_9268;KIF22_8963;KIF18B_32882;JUN_8938;CKS2_8325;CCL2_8218;CCL12_8217;ASPM_8092 31.378179999999997 19.9743 3.6768 26.307138599323192 37.00100526963853 26.016574358776513 19.334307 11.7909 1.12034 15.180845488168492 22.259920534268304 14.193459904518942 100.05261 37.9409 11.7489 114.28722455874498 144.5654684531263 132.96656490455817 13.8391;79.3182;31.6605;13.2391;3.6768;57.7663;14.4197;64.0097;25.5289;10.3235 9.31624;39.4261;23.5989;9.02099;1.12034;38.6865;9.6236;41.1311;13.9582;7.4611 27.6952;264.141;46.786;25.4349;11.7489;109.049;29.0958;132.851;336.862;16.8623 5 5 5 360243;293502;303575;498709;289054 TOP2A_10059;KIF22_8963;KIF18B_32882;CKS2_8325;ASPM_8092 11.099639999999999 13.2391 4.438628041185703 7.308454 9.02099 3.558087297015068 22.16742 25.4349 7.515402249846653 13.8391;13.2391;3.6768;14.4197;10.3235 9.31624;9.02099;1.12034;9.6236;7.4611 27.6952;25.4349;11.7489;29.0958;16.8623 5 24587;286918;24516;24770;287562 NEFH_33218;MX2_9268;JUN_8938;CCL2_8218;CCL12_8217 51.65671999999999 57.7663 22.56984908394384 31.36016 38.6865 12.013235232359351 177.9378 132.851 119.0243399254959 79.3182;31.6605;57.7663;64.0097;25.5289 39.4261;23.5989;38.6865;41.1311;13.9582 264.141;46.786;109.049;132.851;336.862 0 Exp 2,4(0.4);Exp 4,1(0.1);Poly 2,5(0.5) 1.7234885468469374 17.494064211845398 1.5230457782745361 2.6565301418304443 0.34965028041051494 1.5883848667144775 15.072846567663778 47.68351343233623 9.925121484258183 28.743492515741814 29.21665433530582 170.88856566469417 CONFLICT 0.5 0.5 0.0 GO:0018130 5 heterocycle biosynthetic process 162 180 5 4 4 5 4 4 65 176 2302 0.4546 0.73104 1.0 2.22 78968;287877;114519;24516 srebf1;pycr1;nfil3;jun SREBF1_32750;PYCR1_9631;NFIL3_9304;JUN_8938 39.207275 43.91355 11.2357 21.636128345335568 46.52567743129556 17.803297248749427 26.904827499999996 31.9943 4.94421 15.859586164368391 32.233528773415586 12.565812896709298 68.79705000000001 70.78105 24.5771 39.790570574488264 81.79120609646662 34.6221968184761 11.2357;54.7122;33.1149;57.7663 4.94421;38.3856;25.603;38.6865 24.5771;94.9303;46.6318;109.049 2 2 2 78968;287877 SREBF1_32750;PYCR1_9631 32.97395 32.97395 30.742527972256937 21.664904999999997 21.664904999999997 23.646633641304003 59.7537 59.7537 49.747224798173406 11.2357;54.7122 4.94421;38.3856 24.5771;94.9303 2 114519;24516 NFIL3_9304;JUN_8938 45.4406 45.4406 17.431172105742025 32.14475 32.14475 9.251431571654184 77.8404 77.8404 44.13562538267699 33.1149;57.7663 25.603;38.6865 46.6318;109.049 0 Exp 2,1(0.25);Hill,1(0.25);Linear,2(0.5) 2.1274813210580334 8.876129746437073 1.5230457782745361 2.857419490814209 0.7267285419723671 2.247832238674164 18.003869221571136 60.410680778428855 11.362433058918985 42.44722194108101 29.802290837001472 107.79180916299853 CONFLICT 0.5 0.5 0.0 GO:0001938 8 positive regulation of endothelial cell proliferation 29 29 3 3 2 2 2 2 67 27 2451 0.95795 0.18446 0.18446 6.9 24516;24770 jun;ccl2 JUN_8938;CCL2_8218 60.888 60.888 57.7663 4.41475047766004 59.908792904330795 4.1919361526128185 39.9088 39.9088 38.6865 1.7285932372889559 39.52539197455346 1.6413504050163845 120.95 120.95 109.049 16.83055560580231 117.21692390506483 15.981110341238901 0.5 60.888 57.7663;64.0097 38.6865;41.1311 109.049;132.851 0 2 0 2 24516;24770 JUN_8938;CCL2_8218 60.888 60.888 4.41475047766004 39.9088 39.9088 1.7285932372889559 120.95 120.95 16.83055560580231 57.7663;64.0097 38.6865;41.1311 109.049;132.851 0 Exp 2,2(1) 1.5413941581540127 3.083009362220764 1.5230457782745361 1.559963583946228 0.026104830736980524 1.541504681110382 54.769468 67.00653199999999 37.513092 42.304508 97.62404000000001 144.27596 DOWN 0.0 1.0 0.0 GO:0010564 6 regulation of cell cycle process 146 156 7 7 6 5 5 5 64 151 2327 0.75494 0.41705 0.61084 3.21 361921;114851;58919;24770;282840 ect2;cdkn1a;ccnd1;ccl2;atf5 ECT2_8523;CDKN1A_8271;CCND1_8224;CCL2_8218;ATF5_8097 51.838699999999996 54.5478 14.4142 32.55224436217879 56.42011811437403 32.955151835679665 37.30887 38.2987 9.59235 24.72555678067735 41.435543283530826 25.48998259340288 82.10682 94.4701 30.0753 45.88107775605322 83.44555655504035 40.86117024746987 14.4142;54.5478;28.2655;64.0097;97.9563 9.59235;38.2987;22.3101;41.1311;75.2121 30.0753;94.4701;38.3337;132.851;114.804 2 3 2 361921;58919 ECT2_8523;CCND1_8224 21.33985 21.33985 9.794348158249228 15.951224999999999 15.951224999999999 8.992807266435213 34.204499999999996 34.204499999999996 5.839570641751015 14.4142;28.2655 9.59235;22.3101 30.0753;38.3337 3 114851;24770;282840 CDKN1A_8271;CCL2_8218;ATF5_8097 72.17126666666667 64.0097 22.826143912262832 51.54730000000001 41.1311 20.543190884572905 114.04169999999999 114.804 19.20180192507992 54.5478;64.0097;97.9563 38.2987;41.1311;75.2121 94.4701;132.851;114.804 0 Exp 2,1(0.2);Linear,2(0.4);Poly 2,2(0.4) 1.9037100848275543 9.657842993736267 1.559963583946228 2.385996103286743 0.3714275374342513 1.7797720432281494 23.305399764105708 80.37200023589429 15.63596390869483 58.981776091305164 41.89028217255252 122.32335782744748 DOWN 0.4 0.6 0.0 GO:0022407 6 regulation of cell-cell adhesion 137 143 6 6 5 5 5 5 64 138 2340 0.81203 0.34526 0.59006 3.5 29142;29692;24367;24770;81639 vnn1;pla2g2a;fgg;ccl2;alox15 VNN1_10157;PLA2G2A_32641;FGG_8639;CCL2_8218;ALOX15_8036 56.73690000000023 64.0097 1.16694E-12 45.48830000769392 68.18532906543199 46.166584492999796 38.68374000000024 41.1311 1.16694E-12 32.27140846659744 49.58892567356285 35.77068976495354 123.24328000000023 129.44 1.16694E-12 128.783433334773 120.89965791436151 107.51844255690668 20.8684;1.16694E-12;93.1824;64.0097;105.624 17.1194;1.16694E-12;51.338;41.1311;83.8302 26.5474;1.16694E-12;327.378;132.851;129.44 2 3 2 29142;81639 VNN1_10157;ALOX15_8036 63.2462 63.2462 59.93125950353453 50.4748 50.4748 47.17165905837953 77.9937 77.9937 72.75605519391495 20.8684;105.624 17.1194;83.8302 26.5474;129.44 3 29692;24367;24770 PLA2G2A_32641;FGG_8639;CCL2_8218 52.39736666666706 64.0097 47.66418604700254 30.823033333333722 41.1311 27.177007557921048 153.40966666666705 132.851 164.65443450552175 1.16694E-12;93.1824;64.0097 1.16694E-12;51.338;41.1311 1.16694E-12;327.378;132.851 0 Exp 2,3(0.6);Hill,1(0.2);Poly 2,1(0.2) 1.9254179567409924 9.790918707847595 1.559963583946228 2.642244338989258 0.4186295444535559 1.9088982343673706 16.86464704874198 96.6091529512585 10.396603280098372 66.9708767199021 10.359623565553207 236.12693643444726 DOWN 0.4 0.6 0.0 GO:0060137 4 maternal process involved in parturition 6 6 2 2 2 2 2 2 67 4 2474 0.99964 0.010113 0.010113 33.33 24770;29657 ccl2;arntl CCL2_8218;ARNTL_8086 51.113699999999994 51.113699999999994 38.2177 18.23769810036345 45.62949797151931 16.50638325683784 34.12735 34.12735 27.1236 9.904798237470564 31.148908626165355 8.964530221392527 98.0272 98.0272 63.2034 49.24829025336826 83.21789830959945 44.573122616273984 0.0 38.2177 0.0 38.2177 64.0097;38.2177 41.1311;27.1236 132.851;63.2034 0 2 0 2 24770;29657 CCL2_8218;ARNTL_8086 51.113699999999994 51.113699999999994 18.23769810036345 34.12735 34.12735 9.904798237470564 98.0272 98.0272 49.24829025336826 64.0097;38.2177 41.1311;27.1236 132.851;63.2034 0 Exp 2,1(0.5);Power,1(0.5) 2.763928606558108 6.457065939903259 1.559963583946228 4.897102355957031 2.359713455449387 3.2285329699516296 25.83754 76.38985999999998 20.4 47.8547 29.772552000000005 166.28184799999997 DOWN 0.0 1.0 0.0 GO:0046483 4 heterocycle metabolic process 413 462 13 12 12 12 11 11 58 451 2027 0.38506 0.73196 0.75192 2.38 360847;360243;78968;287877;362282;114519;293502;24516;24450;25086;29680 ube2t;top2a;srebf1;pycr1;pck1;nfil3;kif22;jun;hmgcs2;cyp2e1;cyp11a1 UBE2T_10125;TOP2A_10059;SREBF1_32750;PYCR1_9631;PCK1_9439;NFIL3_9304;KIF22_8963;JUN_8938;HMGCS2_8812;CYP2E1_8421;CYP11A1_32785 29.48033363636364 30.5985 5.51457 19.53034022266497 34.06168883948101 19.503131998301455 20.020253636363638 24.577 1.34064 13.882111105058392 23.69442435847087 13.50343167880439 51.11479090909091 40.5656 18.2059 30.193969299827238 57.364417443825815 33.99637980559884 10.9914;13.8391;11.2357;54.7122;5.51457;33.1149;13.2391;57.7663;30.5985;49.5529;43.719 7.86591;9.31624;4.94421;38.3856;1.34064;25.603;9.02099;38.6865;24.577;26.9979;33.4848 18.2059;27.6952;24.5771;94.9303;39.6721;46.6318;25.4349;109.049;40.5656;71.5977;63.9031 9 2 9 360847;360243;78968;287877;362282;293502;24450;25086;29680 UBE2T_10125;TOP2A_10059;SREBF1_32750;PYCR1_9631;PCK1_9439;KIF22_8963;HMGCS2_8812;CYP2E1_8421;CYP11A1_32785 25.933607777777777 13.8391 18.99941626573813 17.32592111111111 9.31624 13.611573325912257 45.17576666666667 39.6721 26.035648517321388 10.9914;13.8391;11.2357;54.7122;5.51457;13.2391;30.5985;49.5529;43.719 7.86591;9.31624;4.94421;38.3856;1.34064;9.02099;24.577;26.9979;33.4848 18.2059;27.6952;24.5771;94.9303;39.6721;25.4349;40.5656;71.5977;63.9031 2 114519;24516 NFIL3_9304;JUN_8938 45.4406 45.4406 17.431172105742025 32.14475 32.14475 9.251431571654184 77.8404 77.8404 44.13562538267699 33.1149;57.7663 25.603;38.6865 46.6318;109.049 0 Exp 2,3(0.28);Hill,2(0.19);Linear,2(0.19);Poly 2,4(0.37) 2.1494366120632216 24.42069673538208 1.5230457782745361 3.3687045574188232 0.6023741928924339 2.2035675048828125 17.93864012079372 41.02202715193356 11.816450226030083 28.22405704669719 33.271295316898886 68.95828650128293 UP 0.8181818181818182 0.18181818181818182 0.0 GO:0010033 4 response to organic substance 795 856 44 42 39 39 35 35 34 821 1657 0.99903 0.002173 0.0040993 4.09 360243;24825;78968;84386;24777;25044;83792;360918;362282;114519;24587;286918;58827;24516;79438;24450;85430;360504;316033;81660;24367;116663;170568;24306;25086;29680;299691;84032;114851;58919;24770;287562;25612;25649;81639 top2a;tf;srebf1;slpi;slc10a1;sds;scd2;pf4;pck1;nfil3;nefh;mx2;mest;jun;igfals;hmgcs2;herpud1;hba-a2;glb1;gatm;fgg;dusp6;dmbt1;cyp4a2;cyp2e1;cyp11a1;cry1;col3a1;cdkn1a;ccnd1;ccl2;ccl12;asns;apoa2;alox15 TOP2A_10059;TF_10003;SREBF1_32750;SLPI_9890;SLC10A1_9832;SDS_9798;SCD_9786;PF4_32963;PCK1_9439;NFIL3_9304;NEFH_33218;MX2_9268;MEST_9219;JUN_8938;IGFALS_8880;HMGCS2_8812;HERPUD1_8795;HBA2_32600;GLB1_8712;GATM_32792;FGG_8639;DUSP6_8506;DMBT1_32993;CYP4A2_8425;CYP2E1_8421;CYP11A1_32785;CRY1_8386;COL3A1_8354;CDKN1A_8271;CCND1_8224;CCL2_8218;CCL12_8217;ASNS_8091;APOA2_33095;ALOX15_8036 54.619822571428564 54.5478 5.51457 28.4652769380043 53.776426912284705 25.623443655975517 36.23652114285714 38.2987 1.34064 19.292700552127567 35.8195947466477 17.25978773341013 120.78543714285713 100.108 11.4863 87.45862342916655 127.76079663601432 90.02105952517243 13.8391;51.412;11.2357;56.5193;7.96762;64.7394;83.9984;105.82;5.51457;33.1149;79.3182;31.6605;96.9172;57.7663;70.3663;30.5985;53.893;101.406;65.9159;37.423;93.1824;45.5478;21.7434;59.5671;49.5529;43.719;37.2548;57.8774;54.5478;28.2655;64.0097;25.5289;85.6642;80.183;105.624 9.31624;36.6131;4.94421;39.3315;6.07525;43.4259;54.1928;53.8521;1.34064;25.603;39.4261;23.5989;56.7353;38.6865;46.0459;24.577;37.9512;84.6435;47.8573;28.03;51.338;33.3115;12.6557;43.4174;26.9979;33.4848;21.8798;39.4215;38.2987;22.3101;41.1311;13.9582;53.6991;50.2978;83.8302 27.6952;86.0232;24.5771;100.108;11.4863;126.828;206.18;109.875;39.6721;46.6318;264.141;46.786;331.492;109.049;148.796;40.5656;92.6554;115.953;114.587;55.6613;327.378;71.7388;160.485;99.5908;71.5977;63.9031;73.8251;106.603;94.4701;38.3337;132.851;336.862;224.488;197.161;129.44 17 18 17 360243;24825;78968;83792;362282;24450;85430;360504;316033;170568;24306;25086;29680;58919;25612;25649;81639 TOP2A_10059;TF_10003;SREBF1_32750;SCD_9786;PCK1_9439;HMGCS2_8812;HERPUD1_8795;HBA2_32600;GLB1_8712;DMBT1_32993;CYP4A2_8425;CYP2E1_8421;CYP11A1_32785;CCND1_8224;ASNS_8091;APOA2_33095;ALOX15_8036 52.4783688235294 51.412 31.43360994823295 36.94876411764706 36.6131 24.38627972182233 101.93575882352943 92.6554 63.92906840889225 13.8391;51.412;11.2357;83.9984;5.51457;30.5985;53.893;101.406;65.9159;21.7434;59.5671;49.5529;43.719;28.2655;85.6642;80.183;105.624 9.31624;36.6131;4.94421;54.1928;1.34064;24.577;37.9512;84.6435;47.8573;12.6557;43.4174;26.9979;33.4848;22.3101;53.6991;50.2978;83.8302 27.6952;86.0232;24.5771;206.18;39.6721;40.5656;92.6554;115.953;114.587;160.485;99.5908;71.5977;63.9031;38.3337;224.488;197.161;129.44 18 84386;24777;25044;360918;114519;24587;286918;58827;24516;79438;81660;24367;116663;299691;84032;114851;24770;287562 SLPI_9890;SLC10A1_9832;SDS_9798;PF4_32963;NFIL3_9304;NEFH_33218;MX2_9268;MEST_9219;JUN_8938;IGFALS_8880;GATM_32792;FGG_8639;DUSP6_8506;CRY1_8386;COL3A1_8354;CDKN1A_8271;CCL2_8218;CCL12_8217 56.64230666666668 57.1428 26.108947513202274 35.56384722222222 39.009 13.554385100862811 138.5879111111111 107.826 103.73341773778132 56.5193;7.96762;64.7394;105.82;33.1149;79.3182;31.6605;96.9172;57.7663;70.3663;37.423;93.1824;45.5478;37.2548;57.8774;54.5478;64.0097;25.5289 39.3315;6.07525;43.4259;53.8521;25.603;39.4261;23.5989;56.7353;38.6865;46.0459;28.03;51.338;33.3115;21.8798;39.4215;38.2987;41.1311;13.9582 100.108;11.4863;126.828;109.875;46.6318;264.141;46.786;331.492;109.049;148.796;55.6613;327.378;71.7388;73.8251;106.603;94.4701;132.851;336.862 0 Exp 2,14(0.4);Exp 3,1(0.03);Hill,2(0.06);Linear,11(0.32);Poly 2,7(0.2) 1.9231912706968723 68.76443934440613 1.5230457782745361 3.3687045574188232 0.4403832510296305 1.8739502429962158 45.189263004286076 64.05038213857107 29.844840423778294 42.628201861936006 91.81035428294432 149.76052000276994 CONFLICT 0.4857142857142857 0.5142857142857142 0.0 GO:0032101 5 regulation of response to external stimulus 254 266 10 10 7 9 6 6 63 260 2218 0.40749 0.74305 0.84126 2.26 84386;314654;24367;114851;24770;81639 slpi;myo1f;fgg;cdkn1a;ccl2;alox15 SLPI_9890;MYO1F_32715;FGG_8639;CDKN1A_8271;CCL2_8218;ALOX15_8036 77.64013333333334 77.98365 54.5478 21.885076517267766 73.51710379762729 23.44018360383916 52.51028333333333 46.23455 38.2987 17.673619434333954 51.84757570146255 19.658660118985207 149.15901666666664 120.0735 94.4701 88.64788150227658 124.42343312409767 62.430087035420044 56.5193;91.9576;93.1824;54.5478;64.0097;105.624 39.3315;61.1322;51.338;38.2987;41.1311;83.8302 100.108;110.707;327.378;94.4701;132.851;129.44 2 4 2 314654;81639 MYO1F_32715;ALOX15_8036 98.79079999999999 98.79079999999999 9.663604114407997 72.4812 72.4812 16.049909719372263 120.0735 120.0735 13.246231331967573 91.9576;105.624 61.1322;83.8302 110.707;129.44 4 84386;24367;114851;24770 SLPI_9890;FGG_8639;CDKN1A_8271;CCL2_8218 67.06479999999999 60.2645 17.882445069769798 42.524825 40.231300000000005 5.990881405032695 163.701775 116.4795 110.42172188237767 56.5193;93.1824;54.5478;64.0097 39.3315;51.338;38.2987;41.1311 100.108;327.378;94.4701;132.851 0 Exp 2,2(0.34);Linear,2(0.34);Poly 2,2(0.34) 1.6615970055859457 9.99355959892273 1.559963583946228 1.9088982343673706 0.12979511537402771 1.6254538297653198 60.12842498663633 95.15184168003034 38.36844248939688 66.6521241772698 78.22593835663353 220.0920949766998 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0051649 4 establishment of localization in cell 242 254 6 6 6 6 6 6 63 248 2230 0.45882 0.70029 0.84081 2.36 314654;286918;293502;85430;114851;29657 myo1f;mx2;kif22;herpud1;cdkn1a;arntl MYO1F_32715;MX2_9268;KIF22_8963;HERPUD1_8795;CDKN1A_8271;ARNTL_8086 47.25261666666666 46.055350000000004 13.2391 26.748880585431365 45.450094783258166 22.212146980559154 32.854265 32.5374 9.02099 17.56012258828935 31.948195137169282 14.468570483938853 72.20946666666667 77.9294 25.4349 32.591268892245765 71.03812492602913 29.026921552513258 91.9576;31.6605;13.2391;53.893;54.5478;38.2177 61.1322;23.5989;9.02099;37.9512;38.2987;27.1236 110.707;46.786;25.4349;92.6554;94.4701;63.2034 3 3 3 314654;293502;85430 MYO1F_32715;KIF22_8963;HERPUD1_8795 53.0299 53.893 39.366346881187745 36.034796666666665 37.9512 26.108408668818434 76.26576666666666 92.6554 44.93659778180068 91.9576;13.2391;53.893 61.1322;9.02099;37.9512 110.707;25.4349;92.6554 3 286918;114851;29657 MX2_9268;CDKN1A_8271;ARNTL_8086 41.47533333333333 38.2177 11.786274072977182 29.67373333333333 27.1236 7.674530280305983 68.15316666666666 63.2034 24.224336745168777 31.6605;54.5478;38.2177 23.5989;38.2987;27.1236 46.786;94.4701;63.2034 0 Exp 2,1(0.17);Linear,2(0.34);Poly 2,2(0.34);Power,1(0.17) 2.0961012262895693 13.948432683944702 1.5270863771438599 4.897102355957031 1.3300836710280037 1.6406752467155457 25.849054515850906 68.65617881748243 18.80324054707021 46.905289452929786 46.13102024042414 98.2879130929092 CONFLICT 0.5 0.5 0.0 GO:0034599 5 cellular response to oxidative stress 95 101 5 5 4 4 4 4 65 97 2381 0.86413 0.29171 0.35068 3.96 287877;24587;24516;361921 pycr1;nefh;jun;ect2 PYCR1_9631;NEFH_33218;JUN_8938;ECT2_8523 51.552725 56.23925 14.4142 27.072633400462426 56.939939256111415 24.521110973108478 31.522637499999995 38.53605 9.59235 14.626726787139548 34.21022763916354 12.37158292044799 124.5489 101.98965000000001 30.0753 99.2114305332136 142.4547134093491 101.34268534669565 54.7122;79.3182;57.7663;14.4142 38.3856;39.4261;38.6865;9.59235 94.9303;264.141;109.049;30.0753 2 2 2 287877;361921 PYCR1_9631;ECT2_8523 34.5632 34.5632 28.494989068255492 23.988974999999996 23.988974999999996 20.35990232739957 62.5028 62.5028 45.859410293853536 54.7122;14.4142 38.3856;9.59235 94.9303;30.0753 2 24587;24516 NEFH_33218;JUN_8938 68.54225 68.54225 15.239494637454422 39.0563 39.0563 0.5229761753654164 186.59500000000003 186.59500000000003 109.66660490778396 79.3182;57.7663 39.4261;38.6865 264.141;109.049 0 Exp 2,2(0.5);Linear,1(0.25);Poly 2,1(0.25) 1.6792672555671573 6.730043172836304 1.5230457782745361 1.7797720432281494 0.11908847809464572 1.713612675666809 25.021544267546833 78.08390573245318 17.188445248603266 45.85682975139674 27.321698077450677 221.77610192254934 CONFLICT 0.5 0.5 0.0 GO:0032268 6 regulation of cellular protein metabolic process 600 637 23 23 20 19 18 18 51 619 1859 0.64414 0.46386 0.88791 2.83 24825;78968;84386;29692;24516;85430;24440;24367;361921;116663;299691;498709;114851;58919;24770;287562;29657;81639 tf;srebf1;slpi;pla2g2a;jun;herpud1;hbb;fgg;ect2;dusp6;cry1;cks2;cdkn1a;ccnd1;ccl2;ccl12;arntl;alox15 TF_10003;SREBF1_32750;SLPI_9890;PLA2G2A_32641;JUN_8938;HERPUD1_8795;HBB_8782;FGG_8639;ECT2_8523;DUSP6_8506;CRY1_8386;CKS2_8325;CDKN1A_8271;CCND1_8224;CCL2_8218;CCL12_8217;ARNTL_8086;ALOX15_8036 46.84817222222229 48.4799 1.16694E-12 29.466278540528318 47.17911037223192 25.796376627670874 31.36944222222229 34.9623 1.16694E-12 20.513989893107002 32.37673809878217 19.52872287925165 112.04010555555561 89.33930000000001 1.16694E-12 100.32020811442 116.26282289129455 97.21965122364689 51.412;11.2357;56.5193;1.16694E-12;57.7663;53.893;91.4283;93.1824;14.4142;45.5478;37.2548;14.4197;54.5478;28.2655;64.0097;25.5289;38.2177;105.624 36.6131;4.94421;39.3315;1.16694E-12;38.6865;37.9512;54.7263;51.338;9.59235;33.3115;21.8798;9.6236;38.2987;22.3101;41.1311;13.9582;27.1236;83.8302 86.0232;24.5771;100.108;1.16694E-12;109.049;92.6554;277.036;327.378;30.0753;71.7388;73.8251;29.0958;94.4701;38.3337;132.851;336.862;63.2034;129.44 7 11 7 24825;78968;85430;361921;498709;58919;81639 TF_10003;SREBF1_32750;HERPUD1_8795;ECT2_8523;CKS2_8325;CCND1_8224;ALOX15_8036 39.89487142857143 28.2655 33.92086270363782 29.266394285714284 22.3101 27.445324112066807 61.45721428571428 38.3337 41.080001259551615 51.412;11.2357;53.893;14.4142;14.4197;28.2655;105.624 36.6131;4.94421;37.9512;9.59235;9.6236;22.3101;83.8302 86.0232;24.5771;92.6554;30.0753;29.0958;38.3337;129.44 11 84386;29692;24516;24440;24367;116663;299691;114851;24770;287562;29657 SLPI_9890;PLA2G2A_32641;JUN_8938;HBB_8782;FGG_8639;DUSP6_8506;CRY1_8386;CDKN1A_8271;CCL2_8218;CCL12_8217;ARNTL_8086 51.27300000000011 54.5478 27.023856673576184 32.70774545454556 38.2987 16.07441477524827 144.22921818181828 100.108 114.7419368497395 56.5193;1.16694E-12;57.7663;91.4283;93.1824;45.5478;37.2548;54.5478;64.0097;25.5289;38.2177 39.3315;1.16694E-12;38.6865;54.7263;51.338;33.3115;21.8798;38.2987;41.1311;13.9582;27.1236 100.108;1.16694E-12;109.049;277.036;327.378;71.7388;73.8251;94.4701;132.851;336.862;63.2034 0 Exp 2,4(0.23);Hill,2(0.12);Linear,7(0.39);Poly 2,4(0.23);Power,1(0.06) 1.8767539257795818 35.499611258506775 1.5230457782745361 4.897102355957031 0.8035099721399763 1.7233816385269165 33.23544604562733 60.46089839881725 21.89246239865156 40.84642204579302 65.69453391635759 158.38567719475367 DOWN 0.3888888888888889 0.6111111111111112 0.0 GO:0044283 4 small molecule biosynthetic process 144 161 15 15 13 13 11 11 58 150 2328 0.99899 0.0033735 0.0033735 6.83 25044;83792;287877;362282;24450;81660;24306;29680;299691;25612;81639 sds;scd2;pycr1;pck1;hmgcs2;gatm;cyp4a2;cyp11a1;cry1;asns;alox15 SDS_9798;SCD_9786;PYCR1_9631;PCK1_9439;HMGCS2_8812;GATM_32792;CYP4A2_8425;CYP11A1_32785;CRY1_8386;ASNS_8091;ALOX15_8036 55.346833636363634 54.7122 5.51457 28.729442479972455 57.339270434127464 26.22566109593425 38.751203636363634 38.3856 1.34064 21.367124404967228 40.40562910065666 19.9329760656252 105.00766363636366 94.9303 39.6721 62.636946528199665 104.37332808266981 58.89791408883908 7.5 74.3689 64.7394;83.9984;54.7122;5.51457;30.5985;37.423;59.5671;43.719;37.2548;85.6642;105.624 43.4259;54.1928;38.3856;1.34064;24.577;28.03;43.4174;33.4848;21.8798;53.6991;83.8302 126.828;206.18;94.9303;39.6721;40.5656;55.6613;99.5908;63.9031;73.8251;224.488;129.44 8 3 8 83792;287877;362282;24450;24306;29680;25612;81639 SCD_9786;PYCR1_9631;PCK1_9439;HMGCS2_8812;CYP4A2_8425;CYP11A1_32785;ASNS_8091;ALOX15_8036 58.67474625 57.13965 32.57607105348033 41.6159425 40.9015 24.1378332829048 112.3462375 97.26055 70.62930433392435 83.9984;54.7122;5.51457;30.5985;59.5671;43.719;85.6642;105.624 54.1928;38.3856;1.34064;24.577;43.4174;33.4848;53.6991;83.8302 206.18;94.9303;39.6721;40.5656;99.5908;63.9031;224.488;129.44 3 25044;81660;299691 SDS_9798;GATM_32792;CRY1_8386 46.4724 37.423 15.819909593926253 31.111900000000002 28.03 11.09874709190186 85.43813333333333 73.8251 36.97731337757432 64.7394;37.423;37.2548 43.4259;28.03;21.8798 126.828;55.6613;73.8251 0 Exp 2,7(0.64);Hill,1(0.1);Linear,2(0.19);Poly 2,1(0.1) 1.9702237147175239 22.166462898254395 1.5959433317184448 3.3687045574188232 0.5007310629487353 1.8739502429962158 38.36881808739585 72.32484918533142 26.124040034523702 51.37836723820358 67.99159369915621 142.02373357357106 UP 0.7272727272727273 0.2727272727272727 0.0 GO:0034754 5 cellular hormone metabolic process 34 41 2 2 2 2 2 2 67 39 2439 0.90227 0.30568 0.30568 4.88 499353;29680 cyp2c24;cyp11a1 CYP2C24_32875;CYP11A1_32785 27.14205 27.14205 10.5651 23.44334751278068 19.4749443238612 20.785127464291396 20.560595 20.560595 7.63639 18.277585993890167 14.582942566043123 16.205106988899182 40.4751 40.4751 17.0471 33.13219533927688 29.639273639868623 29.375365566851507 10.5651;43.719 7.63639;33.4848 17.0471;63.9031 1 1 1 29680 CYP11A1_32785 43.719 43.719 33.4848 33.4848 63.9031 63.9031 43.719 33.4848 63.9031 1 499353 CYP2C24_32875 10.5651 10.5651 7.63639 7.63639 17.0471 17.0471 10.5651 7.63639 17.0471 0 Exp 2,1(0.5);Poly 2,1(0.5) 2.003725483784787 4.04338264465332 1.752767562866211 2.2906150817871094 0.38031562787332723 2.02169132232666 -5.348772000000004 59.632872 -4.7708467999999975 45.8920368 -5.443780000000004 86.39398 CONFLICT 0.5 0.5 0.0 GO:0009894 5 regulation of catabolic process 212 227 6 6 4 6 4 4 65 223 2255 0.2491 0.87699 0.51823 1.76 78968;85430;29657;25649 srebf1;herpud1;arntl;apoa2 SREBF1_32750;HERPUD1_8795;ARNTL_8086;APOA2_33095 45.88235 46.055350000000004 11.2357 28.866603077431886 55.62351475853555 26.716646619494494 30.0792025 32.5374 4.94421 19.246328339193038 36.403546936226796 16.39632291103559 94.399225 77.9294 24.5771 73.96244985064493 119.89647593427988 77.53469663209448 11.2357;53.893;38.2177;80.183 4.94421;37.9512;27.1236;50.2978 24.5771;92.6554;63.2034;197.161 3 1 3 78968;85430;25649 SREBF1_32750;HERPUD1_8795;APOA2_33095 48.43723333333333 53.893 34.795927732470844 31.06440333333333 37.9512 23.44798515263164 104.79783333333334 92.6554 86.93031490937632 11.2357;53.893;80.183 4.94421;37.9512;50.2978 24.5771;92.6554;197.161 1 29657 ARNTL_8086 38.2177 38.2177 27.1236 27.1236 63.2034 63.2034 38.2177 27.1236 63.2034 0 Hill,1(0.25);Linear,2(0.5);Power,1(0.25) 2.5475970816299482 11.252878546714783 1.5270863771438599 4.897102355957031 1.495274581610962 2.414344906806946 17.593078984116755 74.17162101588325 11.217800727590824 48.940604272409175 21.916024146367974 166.88242585363201 UP 0.75 0.25 0.0 GO:0045930 7 negative regulation of mitotic cell cycle 62 67 6 6 5 5 5 5 64 62 2416 0.99138 0.033233 0.033233 7.46 360243;304477;114851;58919;24770 top2a;kntc1;cdkn1a;ccnd1;ccl2 TOP2A_10059;KNTC1_8976;CDKN1A_8271;CCND1_8224;CCL2_8218 33.712098000000005 28.2655 7.89839 24.713458705602495 33.20810410611557 23.93482983514628 22.978144 22.3101 3.83458 16.716901581934376 22.949408714960978 16.857567287687996 61.183580000000006 38.3337 12.5679 50.62431346711775 57.29762747059471 46.70962533357286 2.5 41.40665 13.8391;7.89839;54.5478;28.2655;64.0097 9.31624;3.83458;38.2987;22.3101;41.1311 27.6952;12.5679;94.4701;38.3337;132.851 3 2 3 360243;304477;58919 TOP2A_10059;KNTC1_8976;CCND1_8224 16.667663333333333 13.8391 10.474033145643245 11.820306666666667 9.31624 9.488886774587062 26.198933333333333 27.6952 12.947904188065856 13.8391;7.89839;28.2655 9.31624;3.83458;22.3101 27.6952;12.5679;38.3337 2 114851;24770 CDKN1A_8271;CCL2_8218 59.27875 59.27875 6.690573652908962 39.7149 39.7149 2.0028092470327894 113.66055 113.66055 27.139394658042768 54.5478;64.0097 38.2987;41.1311 94.4701;132.851 0 Exp 2,1(0.2);Exp 5,1(0.2);Linear,2(0.4);Poly 2,1(0.2) 1.800091922125425 9.08093512058258 1.559963583946228 2.2675669193267822 0.27987433444162724 1.6944749355316162 12.049796339054431 55.37439966094556 8.325133702331415 37.63115429766858 16.809412759120526 105.55774724087948 UP 0.6 0.4 0.0 GO:1902105 6 regulation of leukocyte differentiation 90 96 4 4 4 4 4 4 65 92 2386 0.88396 0.26109 0.32912 4.17 29142;360918;24516;29339 vnn1;pf4;jun;apcs VNN1_10157;PF4_32963;JUN_8938;APCS_8057 71.602175 79.86015 20.8684 40.23862237257258 78.03816995469403 34.693314895717 42.03915 46.2693 17.1194 18.643081684546335 46.381469169008426 16.473313579551917 160.2731 109.462 26.5474 161.69423178674825 225.83618775018635 178.2846333754128 20.8684;105.82;57.7663;101.954 17.1194;53.8521;38.6865;58.4986 26.5474;109.875;109.049;395.621 1 3 1 29142 VNN1_10157 20.8684 20.8684 17.1194 17.1194 26.5474 26.5474 20.8684 17.1194 26.5474 3 360918;24516;29339 PF4_32963;JUN_8938;APCS_8057 88.51343333333334 101.954 26.697867801817594 50.345733333333335 53.8521 10.361022247024339 204.84833333333333 109.875 165.2144918865574 105.82;57.7663;101.954 53.8521;38.6865;58.4986 109.875;109.049;395.621 0 Exp 2,2(0.5);Exp 3,1(0.25);Linear,1(0.25) 1.8622838943764202 7.629621863365173 1.5230457782745361 2.642244338989258 0.5073871331269041 1.7321658730506897 32.16832507487885 111.03602492512113 23.7689299491446 60.3093700508554 1.8127528489867188 318.73344715101325 DOWN 0.25 0.75 0.0 GO:0001775 3 cell activation 161 172 4 4 4 4 4 4 65 168 2310 0.49624 0.69677 1.0 2.33 360918;299923;314654;24516 pf4;ndrg1;myo1f;jun PF4_32963;NDRG1_32364;MYO1F_32715;JUN_8938 88.802 95.81085 57.7663 21.453593531620708 87.45445264064003 21.387536139856266 49.056349999999995 48.20335 38.6865 10.30585453953243 46.11158832852296 9.573867935058372 108.76 109.462 105.409 2.3342918983427845 107.83822791027394 2.570024649417536 105.82;99.6641;91.9576;57.7663 53.8521;42.5546;61.1322;38.6865 109.875;105.409;110.707;109.049 1 3 1 314654 MYO1F_32715 91.9576 91.9576 61.1322 61.1322 110.707 110.707 91.9576 61.1322 110.707 3 360918;299923;24516 PF4_32963;NDRG1_32364;JUN_8938 87.75013333333334 99.6641 26.148546273613967 45.03106666666667 42.5546 7.880261493334711 108.111 109.049 2.3761675025133773 105.82;99.6641;57.7663 53.8521;42.5546;38.6865 109.875;105.409;109.049 0 Exp 2,1(0.25);Exp 3,2(0.5);Poly 2,1(0.25) 1.6129593715618629 6.471891641616821 1.5226441621780396 1.8398383855819702 0.150910775198894 1.5547045469284058 67.77747833901165 109.82652166098833 38.956612551258274 59.156087448741715 106.47239393962451 111.04760606037547 DOWN 0.25 0.75 0.0 GO:0022412 3 cellular process involved in reproduction in multicellular organism 59 60 2 2 2 2 2 2 67 58 2420 0.77941 0.48831 0.67703 3.33 360243;289054 top2a;aspm TOP2A_10059;ASPM_8092 12.081299999999999 12.081299999999999 10.3235 2.485904599939438 11.715221758436945 2.4313977712641353 8.388670000000001 8.388670000000001 7.4611 1.3117820740504023 8.195494897868562 1.2830194735985159 22.278750000000002 22.278750000000002 16.8623 7.660017049915739 21.15072377886323 7.492060790854266 13.8391;10.3235 9.31624;7.4611 27.6952;16.8623 2 0 2 360243;289054 TOP2A_10059;ASPM_8092 12.081299999999999 12.081299999999999 2.485904599939438 8.388670000000001 8.388670000000001 1.3117820740504023 22.278750000000002 22.278750000000002 7.660017049915739 13.8391;10.3235 9.31624;7.4611 27.6952;16.8623 0 0 Poly 2,2(1) 1.7109536187219896 3.4396687746047974 1.5452834367752075 1.8943853378295898 0.24685232156066889 1.7198343873023987 8.636011999999997 15.526588 6.570632800000001 10.2067072 11.662508000000004 32.894992 UP 1.0 0.0 0.0 GO:0055082 5 cellular chemical homeostasis 190 202 7 5 6 6 5 5 64 197 2281 0.52937 0.65086 1.0 2.48 24825;362282;85430;24770;287562 tf;pck1;herpud1;ccl2;ccl12 TF_10003;PCK1_9439;HERPUD1_8795;CCL2_8218;CCL12_8217 40.071633999999996 51.412 5.51457 23.97053841403611 38.91323594761171 19.397003713155375 26.198847999999998 36.6131 1.34064 17.58771261757823 25.003748371854137 14.917034413685874 137.61274 92.6554 39.6721 116.18729900388423 202.5585580846991 137.06207100656786 51.412;5.51457;53.893;64.0097;25.5289 36.6131;1.34064;37.9512;41.1311;13.9582 86.0232;39.6721;92.6554;132.851;336.862 3 2 3 24825;362282;85430 TF_10003;PCK1_9439;HERPUD1_8795 36.939856666666664 51.412 27.243353718138913 25.30164666666667 36.6131 20.761623449589226 72.78356666666667 86.0232 28.866476020174886 51.412;5.51457;53.893 36.6131;1.34064;37.9512 86.0232;39.6721;92.6554 2 24770;287562 CCL2_8218;CCL12_8217 44.7693 44.7693 27.210034625483285 27.54465 27.54465 19.214141854503943 234.8565 234.8565 144.2575615366488 64.0097;25.5289 41.1311;13.9582 132.851;336.862 0 Exp 2,1(0.2);Hill,1(0.2);Linear,2(0.4);Poly 2,1(0.2) 1.7654690943015368 8.968307852745056 1.5270863771438599 2.3449018001556396 0.3684113400674454 1.559963583946228 19.060530686386556 61.082737313613436 10.78253817519882 41.61515782480117 35.770082111646744 239.45539788835327 UP 0.6 0.4 0.0 GO:0010605 6 negative regulation of macromolecule metabolic process 531 562 19 19 16 17 15 15 54 547 1931 0.54252 0.57456 1.0 2.67 78968;84386;360918;114519;290350;24516;85430;116663;299691;114851;58919;282840;29657;25649;29339 srebf1;slpi;pf4;nfil3;loxl2;jun;herpud1;dusp6;cry1;cdkn1a;ccnd1;atf5;arntl;apoa2;apcs SREBF1_32750;SLPI_9890;PF4_32963;NFIL3_9304;LOXL2_9150;JUN_8938;HERPUD1_8795;DUSP6_8506;CRY1_8386;CDKN1A_8271;CCND1_8224;ATF5_8097;ARNTL_8086;APOA2_33095;APCS_8057 57.847966666666665 54.5478 11.2357 28.107518155638076 59.82472559930216 25.45482668819389 38.070814000000006 38.2987 4.94421 17.18719658214292 40.06870954285038 16.38611847349151 110.76309333333332 94.4701 24.5771 89.29035148123285 122.16759835124597 95.46979509438101 11.2357;56.5193;105.82;33.1149;65.4434;57.7663;53.893;45.5478;37.2548;54.5478;28.2655;97.9563;38.2177;80.183;101.954 4.94421;39.3315;53.8521;25.603;43.7615;38.6865;37.9512;33.3115;21.8798;38.2987;22.3101;75.2121;27.1236;50.2978;58.4986 24.5771;100.108;109.875;46.6318;129.393;109.049;92.6554;71.7388;73.8251;94.4701;38.3337;114.804;63.2034;197.161;395.621 4 11 4 78968;85430;58919;25649 SREBF1_32750;HERPUD1_8795;CCND1_8224;APOA2_33095 43.3943 41.07925 30.147898173172866 28.8758275 30.13065 19.63919877502708 88.18180000000001 65.49455 78.37276326484007 11.2357;53.893;28.2655;80.183 4.94421;37.9512;22.3101;50.2978 24.5771;92.6554;38.3337;197.161 11 84386;360918;114519;290350;24516;116663;299691;114851;282840;29657;29339 SLPI_9890;PF4_32963;NFIL3_9304;LOXL2_9150;JUN_8938;DUSP6_8506;CRY1_8386;CDKN1A_8271;ATF5_8097;ARNTL_8086;APCS_8057 63.10384545454545 56.5193 26.822132619885537 41.41444545454546 38.6865 15.866102521058131 118.97447272727273 100.108 95.08444277598824 56.5193;105.82;33.1149;65.4434;57.7663;45.5478;37.2548;54.5478;97.9563;38.2177;101.954 39.3315;53.8521;25.603;43.7615;38.6865;33.3115;21.8798;38.2987;75.2121;27.1236;58.4986 100.108;109.875;46.6318;129.393;109.049;71.7388;73.8251;94.4701;114.804;63.2034;395.621 0 Exp 2,2(0.14);Exp 3,1(0.07);Hill,1(0.07);Linear,9(0.6);Poly 2,1(0.07);Power,1(0.07) 2.02437559957571 32.14348566532135 1.5230457782745361 4.897102355957031 0.8832272237376626 1.8398383855819702 43.62359990325217 72.07233343008116 29.37289245226401 46.768735547736 65.57594088286069 155.950245783806 DOWN 0.26666666666666666 0.7333333333333333 0.0 GO:0009636 4 response to toxic substance 240 257 15 15 14 14 14 14 55 243 2235 0.99715 0.007487 0.0080716 5.45 78968;24777;24587;24516;24450;24440;360504;361921;25086;29680;114851;58919;24770;25612 srebf1;slc10a1;nefh;jun;hmgcs2;hbb;hba-a2;ect2;cyp2e1;cyp11a1;cdkn1a;ccnd1;ccl2;asns SREBF1_32750;SLC10A1_9832;NEFH_33218;JUN_8938;HMGCS2_8812;HBB_8782;HBA2_32600;ECT2_8523;CYP2E1_8421;CYP11A1_32785;CDKN1A_8271;CCND1_8224;CCL2_8218;ASNS_8091 51.420994285714286 52.05035 7.96762 30.588549861589048 50.78976863463007 27.566234206718015 34.185207857142856 35.89175 4.94421 21.478362403330188 32.82144443803271 16.841549139095775 107.03763571428571 83.0339 11.4863 88.74840817289329 112.90272783636787 91.8111885755557 11.5 88.54624999999999 11.2357;7.96762;79.3182;57.7663;30.5985;91.4283;101.406;14.4142;49.5529;43.719;54.5478;28.2655;64.0097;85.6642 4.94421;6.07525;39.4261;38.6865;24.577;54.7263;84.6435;9.59235;26.9979;33.4848;38.2987;22.3101;41.1311;53.6991 24.5771;11.4863;264.141;109.049;40.5656;277.036;115.953;30.0753;71.5977;63.9031;94.4701;38.3337;132.851;224.488 8 6 8 78968;24450;360504;361921;25086;29680;58919;25612 SREBF1_32750;HMGCS2_8812;HBA2_32600;ECT2_8523;CYP2E1_8421;CYP11A1_32785;CCND1_8224;ASNS_8091 45.607 37.15875 32.55237992984756 32.53112 25.78745 25.774493490745563 76.1866875 52.234350000000006 66.80259227612218 11.2357;30.5985;101.406;14.4142;49.5529;43.719;28.2655;85.6642 4.94421;24.577;84.6435;9.59235;26.9979;33.4848;22.3101;53.6991 24.5771;40.5656;115.953;30.0753;71.5977;63.9031;38.3337;224.488 6 24777;24587;24516;24440;114851;24770 SLC10A1_9832;NEFH_33218;JUN_8938;HBB_8782;CDKN1A_8271;CCL2_8218 59.17298666666667 60.888 28.68793944811421 36.390658333333334 39.0563 16.098552375987616 148.17223333333334 120.95 103.3314630446829 7.96762;79.3182;57.7663;91.4283;54.5478;64.0097 6.07525;39.4261;38.6865;54.7263;38.2987;41.1311 11.4863;264.141;109.049;277.036;94.4701;132.851 0 Exp 2,6(0.43);Hill,1(0.08);Linear,3(0.22);Poly 2,4(0.29) 1.9651743189346922 28.326763153076172 1.5230457782745361 3.3687045574188232 0.5469464374349576 1.7726113200187683 35.397731990069815 67.44425658135876 22.934153589230924 45.43626212505479 60.548376533650824 153.52689489492064 CONFLICT 0.5714285714285714 0.42857142857142855 0.0 GO:0051130 6 positive regulation of cellular component organization 262 280 3 3 3 3 3 3 66 277 2201 0.044545 0.98626 0.078835 1.07 24825;78968;81639 tf;srebf1;alox15 TF_10003;SREBF1_32750;ALOX15_8036 56.09056666666667 51.412 11.2357 47.36775837807117 73.25861239219951 43.960963205014295 41.795836666666666 36.6131 4.94421 39.69754934611246 56.1503370390801 37.22384000710019 80.01343333333334 86.0232 24.5771 52.689134749427545 99.03269016393442 45.551571015472604 51.412;11.2357;105.624 36.6131;4.94421;83.8302 86.0232;24.5771;129.44 3 0 3 24825;78968;81639 TF_10003;SREBF1_32750;ALOX15_8036 56.09056666666667 51.412 47.36775837807117 41.795836666666666 36.6131 39.69754934611246 80.01343333333334 86.0232 52.689134749427545 51.412;11.2357;105.624 36.6131;4.94421;83.8302 86.0232;24.5771;129.44 0 0 Hill,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 2.1319398363726494 6.55376398563385 1.6914535760879517 2.857419490814209 0.603396559525611 2.0048909187316895 2.4889020877091 109.69223124562424 -3.1261693035804328 86.71784263691379 20.390064516670435 139.63680214999624 UP 1.0 0.0 0.0 GO:0030155 5 regulation of cell adhesion 210 219 9 9 8 6 6 6 63 213 2265 0.61805 0.5523 1.0 2.74 29142;29692;314654;24367;24770;81639 vnn1;pla2g2a;myo1f;fgg;ccl2;alox15 VNN1_10157;PLA2G2A_32641;MYO1F_32715;FGG_8639;CCL2_8218;ALOX15_8036 62.60701666666686 77.98365 1.16694E-12 43.15203318678782 72.5017098045973 42.13501741451095 42.425150000000194 46.23455 1.16694E-12 30.284384363281696 51.68486203179619 32.07936712428092 121.15390000000019 120.0735 1.16694E-12 115.30104602257491 119.0489557907173 95.40063488305971 20.8684;1.16694E-12;91.9576;93.1824;64.0097;105.624 17.1194;1.16694E-12;61.1322;51.338;41.1311;83.8302 26.5474;1.16694E-12;110.707;327.378;132.851;129.44 3 3 3 29142;314654;81639 VNN1_10157;MYO1F_32715;ALOX15_8036 72.81666666666666 91.9576 45.5044990027726 54.02726666666666 61.1322 33.91817753673293 88.89813333333332 110.707 54.80366577751289 20.8684;91.9576;105.624 17.1194;61.1322;83.8302 26.5474;110.707;129.44 3 29692;24367;24770 PLA2G2A_32641;FGG_8639;CCL2_8218 52.39736666666706 64.0097 47.66418604700254 30.823033333333722 41.1311 27.177007557921048 153.40966666666705 132.851 164.65443450552175 1.16694E-12;93.1824;64.0097 1.16694E-12;51.338;41.1311 1.16694E-12;327.378;132.851 0 Exp 2,3(0.5);Hill,1(0.17);Poly 2,2(0.34) 1.864252029478026 11.37728202342987 1.559963583946228 2.642244338989258 0.40403254149684853 1.8001759052276611 28.078198860716675 97.13583447261703 18.192595637642018 66.65770436235837 28.893848342273827 213.41395165772656 CONFLICT 0.5 0.5 0.0 GO:0051726 5 regulation of cell cycle 252 268 17 17 15 14 13 13 56 255 2223 0.98923 0.024889 0.028796 4.85 360243;304477;24516;361921;299691;498709;114851;58919;24770;282840;289054;25612;29657 top2a;kntc1;jun;ect2;cry1;cks2;cdkn1a;ccnd1;ccl2;atf5;aspm;asns;arntl TOP2A_10059;KNTC1_8976;JUN_8938;ECT2_8523;CRY1_8386;CKS2_8325;CDKN1A_8271;CCND1_8224;CCL2_8218;ATF5_8097;ASPM_8092;ASNS_8091;ARNTL_8086 40.352091538461536 37.2548 7.89839 29.71991854245675 44.52850697624037 29.784086000722375 27.551451538461542 22.3101 3.83458 21.176896296821464 30.69902608058608 22.02880104326548 74.40929230769231 63.2034 12.5679 60.5100040855706 78.25721790595915 56.827356228561236 13.8391;7.89839;57.7663;14.4142;37.2548;14.4197;54.5478;28.2655;64.0097;97.9563;10.3235;85.6642;38.2177 9.31624;3.83458;38.6865;9.59235;21.8798;9.6236;38.2987;22.3101;41.1311;75.2121;7.4611;53.6991;27.1236 27.6952;12.5679;109.049;30.0753;73.8251;29.0958;94.4701;38.3337;132.851;114.804;16.8623;224.488;63.2034 7 6 7 360243;304477;361921;498709;58919;289054;25612 TOP2A_10059;KNTC1_8976;ECT2_8523;CKS2_8325;CCND1_8224;ASPM_8092;ASNS_8091 24.97494142857143 14.4142 27.52948895199499 16.54815285714286 9.59235 17.35048300068782 54.15974285714286 29.0958 75.59959556516284 13.8391;7.89839;14.4142;14.4197;28.2655;10.3235;85.6642 9.31624;3.83458;9.59235;9.6236;22.3101;7.4611;53.6991 27.6952;12.5679;30.0753;29.0958;38.3337;16.8623;224.488 6 24516;299691;114851;24770;282840;29657 JUN_8938;CRY1_8386;CDKN1A_8271;CCL2_8218;ATF5_8097;ARNTL_8086 58.2921 56.15705 22.20714068123136 40.38863333333333 38.492599999999996 18.649547915986258 98.03376666666666 101.75955 26.179112026397515 57.7663;37.2548;54.5478;64.0097;97.9563;38.2177 38.6865;21.8798;38.2987;41.1311;75.2121;27.1236 109.049;73.8251;94.4701;132.851;114.804;63.2034 0 Exp 2,4(0.31);Exp 5,1(0.08);Linear,2(0.16);Poly 2,5(0.39);Power,1(0.08) 1.9000873179982232 26.20082652568817 1.5230457782745361 4.897102355957031 0.9086054750941194 1.6944749355316162 24.19615978410893 56.508023292814144 16.039559577799103 39.063343499123974 41.515679390634 107.30290522475062 CONFLICT 0.5384615384615384 0.46153846153846156 0.0 GO:0032922 6 circadian regulation of gene expression 22 23 3 3 3 3 3 3 66 20 2458 0.99704 0.022863 0.022863 13.04 316351;299691;29657 npas2;cry1;arntl NPAS2_9350;CRY1_8386;ARNTL_8086 44.5679 38.2177 37.2548 11.842555436644586 43.54456856516977 11.374834245230447 28.266133333333332 27.1236 21.8798 7.027605180524405 27.514145929171228 6.952229053869384 78.82013333333333 73.8251 63.2034 18.62360925178933 77.75826728733114 17.638198463216494 0.5 37.73625 1.5 48.224450000000004 58.2312;37.2548;38.2177 35.795;21.8798;27.1236 99.4319;73.8251;63.2034 0 3 0 3 316351;299691;29657 NPAS2_9350;CRY1_8386;ARNTL_8086 44.5679 38.2177 11.842555436644586 28.266133333333332 27.1236 7.027605180524405 78.82013333333333 73.8251 18.62360925178933 58.2312;37.2548;38.2177 35.795;21.8798;27.1236 99.4319;73.8251;63.2034 0 Exp 2,1(0.34);Power,2(0.67) 3.529409240851283 11.580265283584595 1.8622472286224365 4.897102355957031 1.7306005300782747 4.820915699005127 31.16678696428997 57.969013035710034 20.313649437574362 36.21861722909231 57.745535536319494 99.89473113034717 DOWN 0.0 1.0 0.0 GO:0065007 2 biological regulation 1742 1890 68 66 60 58 52 52 17 1838 640 0.63423 0.47535 0.88984 2.75 29142;360243;24825;78968;84386;24777;291441;287877;29692;360918;362282;338475;316351;114519;24587;299923;314654;286918;58827;366960;290350;100911740;304477;25087;303575;24516;85430;24440;360504;81660;24367;361921;116663;170568;24309;499353;29680;299691;84032;498709;306575;114851;58919;24770;287562;282840;289054;25612;29657;25649;29339;81639 vnn1;top2a;tf;srebf1;slpi;slc10a1;ska1;pycr1;pla2g2a;pf4;pck1;nrep;npas2;nfil3;nefh;ndrg1;myo1f;mx2;mest;maff;loxl2;mrln;kntc1;kng2l1;kif18b;jun;herpud1;hbb;hba-a2;gatm;fgg;ect2;dusp6;dmbt1;dbp;cyp2c24;cyp11a1;cry1;col3a1;cks2;ckap2;cdkn1a;ccnd1;ccl2;ccl12;atf5;aspm;asns;arntl;apoa2;apcs;alox15 VNN1_10157;TOP2A_10059;TF_10003;SREBF1_32750;SLPI_9890;SLC10A1_9832;SKA1_9829;PYCR1_9631;PLA2G2A_32641;PF4_32963;PCK1_9439;NREP_9364;NPAS2_9350;NFIL3_9304;NEFH_33218;NDRG1_32364;MYO1F_32715;MX2_9268;MEST_9219;MAFF_9172;LOXL2_9150;LOC100911740_32571;KNTC1_8976;KNG2_8975;KIF18B_32882;JUN_8938;HERPUD1_8795;HBB_8782;HBA2_32600;GATM_32792;FGG_8639;ECT2_8523;DUSP6_8506;DMBT1_32993;DBP_8439;CYP2C24_32875;CYP11A1_32785;CRY1_8386;COL3A1_8354;CKS2_8325;CKAP2_8324;CDKN1A_8271;CCND1_8224;CCL2_8218;CCL12_8217;ATF5_8097;ASPM_8092;ASNS_8091;ARNTL_8086;APOA2_33095;APCS_8057;ALOX15_8036 50.06334961538464 51.0536 1.16694E-12 32.989049391259016 52.609573184634996 31.012661094441132 32.84880865384618 36.20405 1.16694E-12 21.521733686933686 34.26041943681548 20.077949265503502 108.21994615384618 93.56275 1.16694E-12 96.66012918812838 117.73284643912544 99.06245265246937 20.8684;13.8391;51.412;11.2357;56.5193;7.96762;11.9206;54.7122;1.16694E-12;105.82;5.51457;36.861;58.2312;33.1149;79.3182;99.6641;91.9576;31.6605;96.9172;58.0695;65.4434;91.003;7.89839;73.9369;3.6768;57.7663;53.893;91.4283;101.406;37.423;93.1824;14.4142;45.5478;21.7434;50.6952;10.5651;43.719;37.2548;57.8774;14.4197;12.1218;54.5478;28.2655;64.0097;25.5289;97.9563;10.3235;85.6642;38.2177;80.183;101.954;105.624 17.1194;9.31624;36.6131;4.94421;39.3315;6.07525;8.34831;38.3856;1.16694E-12;53.8521;1.34064;28.0333;35.795;25.603;39.4261;42.5546;61.1322;23.5989;56.7353;40.1293;43.7615;54.5666;3.83458;52.6626;1.12034;38.6865;37.9512;54.7263;84.6435;28.03;51.338;9.59235;33.3115;12.6557;40.5862;7.63639;33.4848;21.8798;39.4215;9.6236;8.47044;38.2987;22.3101;41.1311;13.9582;75.2121;7.4611;53.6991;27.1236;50.2978;58.4986;83.8302 26.5474;27.6952;86.0232;24.5771;100.108;11.4863;21.0483;94.9303;1.16694E-12;109.875;39.6721;53.5645;99.4319;46.6318;264.141;105.409;110.707;46.786;331.492;104.733;129.393;273.335;12.5679;140.016;11.7489;109.049;92.6554;277.036;115.953;55.6613;327.378;30.0753;71.7388;160.485;59.5346;17.0471;63.9031;73.8251;106.603;29.0958;21.3803;94.4701;38.3337;132.851;336.862;114.804;16.8623;224.488;63.2034;197.161;395.621;129.44 24 28 24 29142;360243;24825;78968;291441;287877;362282;314654;366960;304477;25087;303575;85430;360504;361921;170568;29680;498709;306575;58919;289054;25612;25649;81639 VNN1_10157;TOP2A_10059;TF_10003;SREBF1_32750;SKA1_9829;PYCR1_9631;PCK1_9439;MYO1F_32715;MAFF_9172;KNTC1_8976;KNG2_8975;KIF18B_32882;HERPUD1_8795;HBA2_32600;ECT2_8523;DMBT1_32993;CYP11A1_32785;CKS2_8325;CKAP2_8324;CCND1_8224;ASPM_8092;ASNS_8091;APOA2_33095;ALOX15_8036 40.70079416666667 25.00445 33.71228034432491 28.70693375 19.71475 25.354393300981915 75.83747083333334 51.7876 61.66229164482714 20.8684;13.8391;51.412;11.2357;11.9206;54.7122;5.51457;91.9576;58.0695;7.89839;73.9369;3.6768;53.893;101.406;14.4142;21.7434;43.719;14.4197;12.1218;28.2655;10.3235;85.6642;80.183;105.624 17.1194;9.31624;36.6131;4.94421;8.34831;38.3856;1.34064;61.1322;40.1293;3.83458;52.6626;1.12034;37.9512;84.6435;9.59235;12.6557;33.4848;9.6236;8.47044;22.3101;7.4611;53.6991;50.2978;83.8302 26.5474;27.6952;86.0232;24.5771;21.0483;94.9303;39.6721;110.707;104.733;12.5679;140.016;11.7489;92.6554;115.953;30.0753;160.485;63.9031;29.0958;21.3803;38.3337;16.8623;224.488;197.161;129.44 28 84386;24777;29692;360918;338475;316351;114519;24587;299923;286918;58827;290350;100911740;24516;24440;81660;24367;116663;24309;499353;299691;84032;114851;24770;287562;282840;29657;29339 SLPI_9890;SLC10A1_9832;PLA2G2A_32641;PF4_32963;NREP_9364;NPAS2_9350;NFIL3_9304;NEFH_33218;NDRG1_32364;MX2_9268;MEST_9219;LOXL2_9150;LOC100911740_32571;JUN_8938;HBB_8782;GATM_32792;FGG_8639;DUSP6_8506;DBP_8439;CYP2C24_32875;CRY1_8386;COL3A1_8354;CDKN1A_8271;CCL2_8218;CCL12_8217;ATF5_8097;ARNTL_8086;APCS_8057 58.08839714285718 57.1428 30.704818285613083 36.39898714285719 39.009 17.290938049966343 135.97635357142863 102.7585 112.59761677495156 56.5193;7.96762;1.16694E-12;105.82;36.861;58.2312;33.1149;79.3182;99.6641;31.6605;96.9172;65.4434;91.003;57.7663;91.4283;37.423;93.1824;45.5478;50.6952;10.5651;37.2548;57.8774;54.5478;64.0097;25.5289;97.9563;38.2177;101.954 39.3315;6.07525;1.16694E-12;53.8521;28.0333;35.795;25.603;39.4261;42.5546;23.5989;56.7353;43.7615;54.5666;38.6865;54.7263;28.03;51.338;33.3115;40.5862;7.63639;21.8798;39.4215;38.2987;41.1311;13.9582;75.2121;27.1236;58.4986 100.108;11.4863;1.16694E-12;109.875;53.5645;99.4319;46.6318;264.141;105.409;46.786;331.492;129.393;273.335;109.049;277.036;55.6613;327.378;71.7388;59.5346;17.0471;73.8251;106.603;94.4701;132.851;336.862;114.804;63.2034;395.621 0 Exp 2,12(0.24);Exp 3,2(0.04);Exp 4,1(0.02);Exp 5,1(0.02);Hill,3(0.06);Linear,16(0.31);Poly 2,15(0.29);Power,2(0.04) 1.9665935716112781 107.78340291976929 1.5226441621780396 5.737884044647217 0.8508306368377972 1.797882854938507 41.09682385178321 59.02987537898606 26.999134803214055 38.698482504478314 81.94742376621889 134.49246854147347 CONFLICT 0.46153846153846156 0.5384615384615384 0.0 GO:0044057 5 regulation of system process 160 167 7 7 7 5 5 5 64 162 2316 0.70301 0.47706 0.80319 2.99 24825;78968;24367;299691;25649 tf;srebf1;fgg;cry1;apoa2 TF_10003;SREBF1_32750;FGG_8639;CRY1_8386;APOA2_33095 54.65358000000001 51.412 11.2357 32.91868370017245 56.832864805787686 27.125012579325514 33.014582000000004 36.6131 4.94421 19.744212809330232 35.103830015088214 16.919023629462494 141.79288000000003 86.0232 24.5771 121.4257807100576 135.19422522438873 93.68195455117105 51.412;11.2357;93.1824;37.2548;80.183 36.6131;4.94421;51.338;21.8798;50.2978 86.0232;24.5771;327.378;73.8251;197.161 3 2 3 24825;78968;25649 TF_10003;SREBF1_32750;APOA2_33095 47.61023333333333 51.412 34.630515685784026 30.61837 36.6131 23.263482591858438 102.5871 86.0232 87.47612658440015 51.412;11.2357;80.183 36.6131;4.94421;50.2978 86.0232;24.5771;197.161 2 24367;299691 FGG_8639;CRY1_8386 65.21860000000001 65.21860000000001 39.54678521548873 36.6089 36.6089 20.830092981549562 200.60155 200.60155 179.28897497951453 93.1824;37.2548 51.338;21.8798 327.378;73.8251 0 Exp 2,2(0.4);Hill,1(0.2);Linear,2(0.4) 2.0927926896754037 10.604726195335388 1.8622472286224365 2.857419490814209 0.415377569846035 1.9712703227996826 25.79908152250723 83.50807847749277 15.708016414477274 50.32114758552272 35.35849044364082 248.22726955635923 UP 0.6 0.4 0.0 GO:0003008 3 system process 296 309 9 9 9 6 6 6 63 303 2175 0.24966 0.86089 0.45774 1.94 25087;24516;24440;81660;24367;24770 kng2l1;jun;hbb;gatm;fgg;ccl2 KNG2_8975;JUN_8938;HBB_8782;GATM_32792;FGG_8639;CCL2_8218 69.62443333333333 68.9733 37.423 21.251148811832927 59.949076548316256 21.868324687452734 44.42908333333333 46.23455 28.03 10.337702731925836 40.06178426427525 11.466553593010453 173.66521666666665 136.43349999999998 55.6613 105.0822425307039 131.14449317349928 93.14056449833595 73.9369;57.7663;91.4283;37.423;93.1824;64.0097 52.6626;38.6865;54.7263;28.03;51.338;41.1311 140.016;109.049;277.036;55.6613;327.378;132.851 1 5 1 25087 KNG2_8975 73.9369 73.9369 52.6626 52.6626 140.016 140.016 73.9369 52.6626 140.016 5 24516;24440;81660;24367;24770 JUN_8938;HBB_8782;GATM_32792;FGG_8639;CCL2_8218 68.76194000000001 64.0097 23.641805063340644 42.78238 41.1311 10.64179887082067 180.39506 132.851 116.03088461447666 57.7663;91.4283;37.423;93.1824;64.0097 38.6865;54.7263;28.03;51.338;41.1311 109.049;277.036;55.6613;327.378;132.851 0 Exp 2,5(0.84);Linear,1(0.17) 1.7421215486629313 10.538925409317017 1.5230457782745361 2.1833407878875732 0.25317599496784954 1.6818385124206543 52.61997279459842 86.62889387206823 36.157198376773984 52.70096828989269 89.58191075897963 257.7485225743537 DOWN 0.16666666666666666 0.8333333333333334 0.0 GO:0071248 6 cellular response to metal ion 94 103 6 6 6 5 5 5 64 98 2380 0.94226 0.14421 0.1999 4.85 24825;24516;361921;29680;81639 tf;jun;ect2;cyp11a1;alox15 TF_10003;JUN_8938;ECT2_8523;CYP11A1_32785;ALOX15_8036 54.5871 51.412 14.4142 33.003527183772334 62.367443234985636 35.742127302412605 40.44139 36.6131 9.59235 26.927595927793114 46.51107468648822 29.70185781078762 83.69812 86.0232 30.0753 38.75449116318002 93.28257038624653 39.214357625626384 51.412;57.7663;14.4142;43.719;105.624 36.6131;38.6865;9.59235;33.4848;83.8302 86.0232;109.049;30.0753;63.9031;129.44 4 1 4 24825;361921;29680;81639 TF_10003;ECT2_8523;CYP11A1_32785;ALOX15_8036 53.7923 47.5655 38.053896364148216 40.8801125 35.048950000000005 31.072668274878254 77.3604 74.96315 41.650564002984005 51.412;14.4142;43.719;105.624 36.6131;9.59235;33.4848;83.8302 86.0232;30.0753;63.9031;129.44 1 24516 JUN_8938 57.7663 57.7663 38.6865 38.6865 109.049 109.049 57.7663 38.6865 109.049 0 Exp 2,2(0.4);Linear,1(0.2);Poly 2,2(0.4) 1.7435343150659788 8.751929879188538 1.5230457782745361 2.0048909187316895 0.1737804448429438 1.752767562866211 25.65823293017057 83.51596706982944 16.83831149364477 64.04446850635523 49.728310743680076 117.6679292563199 UP 0.8 0.2 0.0 GO:0009314 4 response to radiation 159 166 12 12 11 11 10 10 59 156 2322 0.99572 0.012493 0.012493 6.02 360243;24516;361921;29680;299691;84032;114851;58919;24770;25612 top2a;jun;ect2;cyp11a1;cry1;col3a1;cdkn1a;ccnd1;ccl2;asns TOP2A_10059;JUN_8938;ECT2_8523;CYP11A1_32785;CRY1_8386;COL3A1_8354;CDKN1A_8271;CCND1_8224;CCL2_8218;ASNS_8091 45.7358 49.1334 13.8391 22.797815673534267 46.75723935860059 21.330360054423142 30.782019000000002 35.89175 9.31624 14.50680952900124 31.191208254262747 13.567630118967916 90.12935 84.14760000000001 27.6952 59.31695349113476 92.44555705892748 58.29633705107167 7.5 60.94355 13.8391;57.7663;14.4142;43.719;37.2548;57.8774;54.5478;28.2655;64.0097;85.6642 9.31624;38.6865;9.59235;33.4848;21.8798;39.4215;38.2987;22.3101;41.1311;53.6991 27.6952;109.049;30.0753;63.9031;73.8251;106.603;94.4701;38.3337;132.851;224.488 5 5 5 360243;361921;29680;58919;25612 TOP2A_10059;ECT2_8523;CYP11A1_32785;CCND1_8224;ASNS_8091 37.1804 28.2655 29.732237312973947 25.680517999999996 22.3101 18.60057940212133 76.89905999999999 38.3337 83.74389756575103 13.8391;14.4142;43.719;28.2655;85.6642 9.31624;9.59235;33.4848;22.3101;53.6991 27.6952;30.0753;63.9031;38.3337;224.488 5 24516;299691;84032;114851;24770 JUN_8938;CRY1_8386;COL3A1_8354;CDKN1A_8271;CCL2_8218 54.2912 57.7663 10.120414532270901 35.883520000000004 38.6865 7.903296202977567 103.35964000000001 106.603 21.586694341491867 57.7663;37.2548;57.8774;54.5478;64.0097 38.6865;21.8798;39.4215;38.2987;41.1311 109.049;73.8251;106.603;94.4701;132.851 0 Exp 2,6(0.6);Linear,2(0.2);Poly 2,2(0.2) 1.7372203433556295 17.489713430404663 1.5230457782745361 2.2675669193267822 0.22276825429459585 1.7086559534072876 31.605567451809428 59.86603254819057 21.790605299999836 39.77343270000016 53.36432132872459 126.89437867127538 CONFLICT 0.5 0.5 0.0 GO:0007062 5 sister chromatid cohesion 12 13 1 1 1 1 1 1 68 12 2466 0.95346 0.30085 0.30085 7.69 293502 kif22 KIF22_8963 13.2391 13.2391 13.2391 13.2391 9.02099 9.02099 9.02099 9.02099 25.4349 25.4349 25.4349 25.4349 0.0 13.2391 13.2391 9.02099 25.4349 1 0 1 293502 KIF22_8963 13.2391 13.2391 9.02099 9.02099 25.4349 25.4349 13.2391 9.02099 25.4349 0 0 Poly 2,1(1) 1.616806149482727 1.616806149482727 1.616806149482727 1.616806149482727 0.0 1.616806149482727 13.2391 13.2391 9.02099 9.02099 25.4349 25.4349 UP 1.0 0.0 0.0 GO:0044255 4 cellular lipid metabolic process 218 243 14 14 12 13 11 11 58 232 2246 0.97256 0.059087 0.091413 4.53 83792;29692;362282;24450;171142;29740;24306;25086;499353;25649;81639 scd2;pla2g2a;pck1;hmgcs2;ehhadh;eci1;cyp4a2;cyp2e1;cyp2c24;apoa2;alox15 SCD_9786;PLA2G2A_32641;PCK1_9439;HMGCS2_8812;EHHADH_8534;ECI1_8520;CYP4A2_8425;CYP2E1_8421;CYP2C24_32875;APOA2_33095;ALOX15_8036 51.04819727272738 49.5529 1.16694E-12 38.45002226076951 59.523543230787034 35.98020914534237 33.44829363636374 26.9979 1.16694E-12 25.73519189925184 40.26451236074532 24.95218271570256 86.68659090909104 71.5977 1.16694E-12 68.96586985379714 104.47662009652184 72.13823891688443 83.9984;1.16694E-12;5.51457;30.5985;32.6956;103.231;59.5671;49.5529;10.5651;80.183;105.624 54.1928;1.16694E-12;1.34064;24.577;25.6436;49.9975;43.4174;26.9979;7.63639;50.2978;83.8302 206.18;1.16694E-12;39.6721;40.5656;45.0542;107.244;99.5908;71.5977;17.0471;197.161;129.44 9 2 9 83792;362282;24450;171142;29740;24306;25086;25649;81639 SCD_9786;PCK1_9439;HMGCS2_8812;EHHADH_8534;ECI1_8520;CYP4A2_8425;CYP2E1_8421;APOA2_33095;ALOX15_8036 61.21834111111111 59.5671 34.656089071236266 40.032759999999996 43.4174 23.579020147026906 104.05615555555558 99.5908 63.721437057439886 83.9984;5.51457;30.5985;32.6956;103.231;59.5671;49.5529;80.183;105.624 54.1928;1.34064;24.577;25.6436;49.9975;43.4174;26.9979;50.2978;83.8302 206.18;39.6721;40.5656;45.0542;107.244;99.5908;71.5977;197.161;129.44 2 29692;499353 PLA2G2A_32641;CYP2C24_32875 5.282550000000583 5.282550000000583 7.470653853913168 3.8181950000005833 3.8181950000005833 5.399743152784314 8.523550000000583 8.523550000000583 12.05412000956437 1.16694E-12;10.5651 1.16694E-12;7.63639 1.16694E-12;17.0471 0 Exp 2,4(0.37);Exp 3,1(0.1);Hill,2(0.19);Linear,1(0.1);Poly 2,3(0.28) 2.056810535722288 23.08155071735382 1.618504285812378 3.3687045574188232 0.4807116337124358 1.9712703227996826 28.32568616738385 73.7707083780709 18.239767103843764 48.656820168883726 45.93036629588789 127.44281552229415 UP 0.8181818181818182 0.18181818181818182 0.0 GO:0018057 7 peptidyl-lysine oxidation 2 2 1 1 1 1 1 1 68 1 2477 0.99928 0.053458 0.053458 50.0 290350 loxl2 LOXL2_9150 65.4434 65.4434 65.4434 65.4434 43.7615 43.7615 43.7615 43.7615 129.393 129.393 129.393 129.393 0.0 65.4434 0.0 65.4434 65.4434 43.7615 129.393 0 1 0 1 290350 LOXL2_9150 65.4434 65.4434 43.7615 43.7615 129.393 129.393 65.4434 43.7615 129.393 0 Linear,1(1) 1.7373461723327637 1.7373461723327637 1.7373461723327637 1.7373461723327637 0.0 1.7373461723327637 65.4434 65.4434 43.7615 43.7615 129.393 129.393 DOWN 0.0 1.0 0.0 GO:0050769 7 positive regulation of neurogenesis 132 142 3 3 3 3 3 3 66 139 2339 0.45674 0.75087 1.0 2.11 24825;361921;289054 tf;ect2;aspm TF_10003;ECT2_8523;ASPM_8092 25.383233333333333 14.4142 10.3235 22.634177194308023 28.002372790697674 23.258483216067958 17.88885 9.59235 7.4611 16.25065260804932 19.73300446511628 16.743717382914195 44.32026666666667 30.0753 16.8623 36.71507631346193 48.844607358139534 37.33202183307232 51.412;14.4142;10.3235 36.6131;9.59235;7.4611 86.0232;30.0753;16.8623 3 0 3 24825;361921;289054 TF_10003;ECT2_8523;ASPM_8092 25.383233333333333 14.4142 22.634177194308023 17.88885 9.59235 16.25065260804932 44.32026666666667 30.0753 36.71507631346193 51.412;14.4142;10.3235 36.6131;9.59235;7.4611 86.0232;30.0753;16.8623 0 0 Linear,1(0.34);Poly 2,2(0.67) 1.766665899482562 5.329946398735046 1.5452834367752075 2.0048909187316895 0.2298196583318461 1.7797720432281494 -0.22974932686473792 50.99621599353141 -0.5004945692181622 36.27819456921816 2.773246648592661 85.86728668474068 UP 1.0 0.0 0.0 GO:0030050 6 vesicle transport along actin filament 1 1 1 1 1 1 1 1 68 0 2478 1.0 0.027091 0.027091 100.0 314654 myo1f MYO1F_32715 91.9576 91.9576 91.9576 91.95759999999999 61.1322 61.1322 61.1322 61.13219999999999 110.707 110.707 110.707 110.707 0.0 91.9576 0.0 91.9576 91.9576 61.1322 110.707 1 0 1 314654 MYO1F_32715 91.9576 91.9576 61.1322 61.1322 110.707 110.707 91.9576 61.1322 110.707 0 0 Poly 2,1(1) 1.5863633155822754 1.5863633155822754 1.5863633155822754 1.5863633155822754 0.0 1.5863633155822754 91.9576 91.9576 61.1322 61.1322 110.707 110.707 UP 1.0 0.0 0.0 GO:0045892 8 negative regulation of transcription, DNA-templated 221 232 9 9 8 9 8 8 61 224 2254 0.82875 0.28931 0.40171 3.45 78968;114519;290350;24516;299691;58919;282840;29657 srebf1;nfil3;loxl2;jun;cry1;ccnd1;atf5;arntl SREBF1_32750;NFIL3_9304;LOXL2_9150;JUN_8938;CRY1_8386;CCND1_8224;ATF5_8097;ARNTL_8086 46.156825 37.73625 11.2357 26.837845185417333 51.29354076434464 26.54258541324339 32.440101250000005 26.363300000000002 4.94421 20.84571729417986 36.184184506932276 20.983922230100276 74.9771375 68.51425 24.5771 38.79335071404222 82.37464063772765 35.89480704525893 11.2357;33.1149;65.4434;57.7663;37.2548;28.2655;97.9563;38.2177 4.94421;25.603;43.7615;38.6865;21.8798;22.3101;75.2121;27.1236 24.5771;46.6318;129.393;109.049;73.8251;38.3337;114.804;63.2034 2 6 2 78968;58919 SREBF1_32750;CCND1_8224 19.7506 19.7506 12.04188706225067 13.627154999999998 13.627154999999998 12.279538580339652 31.4554 31.4554 9.727385146070851 11.2357;28.2655 4.94421;22.3101 24.5771;38.3337 6 114519;290350;24516;299691;282840;29657 NFIL3_9304;LOXL2_9150;JUN_8938;CRY1_8386;ATF5_8097;ARNTL_8086 54.9589 47.992000000000004 24.647295640779745 38.711083333333335 32.90505 19.734311479594787 89.48438333333333 91.43705 32.82926144624133 33.1149;65.4434;57.7663;37.2548;97.9563;38.2177 25.603;43.7615;38.6865;21.8798;75.2121;27.1236 46.6318;129.393;109.049;73.8251;114.804;63.2034 0 Exp 2,2(0.25);Hill,1(0.13);Linear,3(0.38);Poly 2,1(0.13);Power,1(0.13) 2.388097189769773 20.366267442703247 1.5230457782745361 4.897102355957031 1.0676743632625534 2.3267815113067627 27.559147123417528 64.75450287658246 17.994756153735977 46.88544634626403 48.0947169722497 101.8595580277503 DOWN 0.25 0.75 0.0 GO:0031099 4 regeneration 111 120 11 10 9 11 9 9 60 111 2367 0.99881 0.0043847 0.0043847 7.5 338475;24587;24516;81660;170568;114851;58919;24770;25649 nrep;nefh;jun;gatm;dmbt1;cdkn1a;ccnd1;ccl2;apoa2 NREP_9364;NEFH_33218;JUN_8938;GATM_32792;DMBT1_32993;CDKN1A_8271;CCND1_8224;CCL2_8218;APOA2_33095 51.12421111111111 54.5478 21.7434 21.3251713447656 52.72914142289074 21.778977172969817 33.2077 38.2987 12.6557 11.42465096283033 34.05927875864454 11.364304932825014 122.85740000000003 109.049 38.3337 74.54476620108883 126.52024464211618 79.10134453926004 5.0 57.7663 36.861;79.3182;57.7663;37.423;21.7434;54.5478;28.2655;64.0097;80.183 28.0333;39.4261;38.6865;28.03;12.6557;38.2987;22.3101;41.1311;50.2978 53.5645;264.141;109.049;55.6613;160.485;94.4701;38.3337;132.851;197.161 3 6 3 170568;58919;25649 DMBT1_32993;CCND1_8224;APOA2_33095 43.3973 28.2655 32.02382301459337 28.4212 22.3101 19.550986688911646 131.99323333333334 160.485 83.15866390318773 21.7434;28.2655;80.183 12.6557;22.3101;50.2978 160.485;38.3337;197.161 6 338475;24587;24516;81660;114851;24770 NREP_9364;NEFH_33218;JUN_8938;GATM_32792;CDKN1A_8271;CCL2_8218 54.98766666666666 56.15705 16.238102002348285 35.60095 38.492599999999996 5.943087006514404 118.28948333333335 101.75955 77.78054390572018 36.861;79.3182;57.7663;37.423;54.5478;64.0097 28.0333;39.4261;38.6865;28.03;38.2987;41.1311 53.5645;264.141;109.049;55.6613;94.4701;132.851 0 Exp 2,4(0.45);Linear,4(0.45);Poly 2,1(0.12) 1.7804097712322806 16.184043288230896 1.5230457782745361 2.2675669193267822 0.2765834222358288 1.6645443439483643 37.191765832530926 65.05665638969128 25.743594704284188 40.67180529571582 74.15481941528859 171.55998058471138 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0006066 4 alcohol metabolic process 93 100 6 6 5 6 5 5 64 95 2383 0.94874 0.13179 0.19247 5.0 78968;362282;24450;29680;25649 srebf1;pck1;hmgcs2;cyp11a1;apoa2 SREBF1_32750;PCK1_9439;HMGCS2_8812;CYP11A1_32785;APOA2_33095 34.250153999999995 30.5985 5.51457 29.86728496158599 49.65476824813184 31.527346718903313 22.928890000000003 24.577 1.34064 20.326718807109522 33.024751037264316 19.249352544081997 73.17578 40.5656 24.5771 70.72140673754305 108.80959138912257 86.7382528037845 4.0 80.183 11.2357;5.51457;30.5985;43.719;80.183 4.94421;1.34064;24.577;33.4848;50.2978 24.5771;39.6721;40.5656;63.9031;197.161 5 0 5 78968;362282;24450;29680;25649 SREBF1_32750;PCK1_9439;HMGCS2_8812;CYP11A1_32785;APOA2_33095 34.250153999999995 30.5985 29.86728496158599 22.928890000000003 24.577 20.326718807109522 73.17578 40.5656 70.72140673754305 11.2357;5.51457;30.5985;43.719;80.183 4.94421;1.34064;24.577;33.4848;50.2978 24.5771;39.6721;40.5656;63.9031;197.161 0 0 Exp 2,2(0.4);Hill,2(0.4);Linear,1(0.2) 2.390046880235504 12.295063734054565 1.752767562866211 3.3687045574188232 0.658779812252623 2.3449018001556396 8.07032444483433 60.42998355516568 5.111735395209635 40.74604460479037 11.185733811613318 135.1658261883867 UP 1.0 0.0 0.0 GO:0030199 6 collagen fibril organization 14 16 2 2 2 2 2 2 67 14 2464 0.99172 0.067982 0.067982 12.5 290350;84032 loxl2;col3a1 LOXL2_9150;COL3A1_8354 61.660399999999996 61.660399999999996 57.8774 5.349969906457553 64.25712592592593 3.890527847381124 41.591499999999996 41.591499999999996 39.4215 3.0688434303497183 43.08103086419753 2.2316799970440084 117.99799999999999 117.99799999999999 106.603 16.114963543241576 125.81975308641975 11.718891044385257 0.0 57.8774 0.5 61.660399999999996 65.4434;57.8774 43.7615;39.4215 129.393;106.603 0 2 0 2 290350;84032 LOXL2_9150;COL3A1_8354 61.660399999999996 61.660399999999996 5.349969906457553 41.591499999999996 41.591499999999996 3.0688434303497183 117.99799999999999 117.99799999999999 16.114963543241576 65.4434;57.8774 43.7615;39.4215 129.393;106.603 0 Exp 2,1(0.5);Linear,1(0.5) 1.6617678250235588 3.3268234729766846 1.589477300643921 1.7373461723327637 0.10455908189758421 1.6634117364883423 54.24572 69.07507999999999 37.338300000000004 45.84469999999999 95.66379999999998 140.3322 DOWN 0.0 1.0 0.0 GO:0007568 3 aging 181 193 12 12 10 9 8 8 61 185 2293 0.92685 0.14731 0.24182 4.15 360243;78968;362282;24516;79438;114851;24770;29657 top2a;srebf1;pck1;jun;igfals;cdkn1a;ccl2;arntl TOP2A_10059;SREBF1_32750;PCK1_9439;JUN_8938;IGFALS_8880;CDKN1A_8271;CCL2_8218;ARNTL_8086 39.43714625 46.38275 5.51457 25.98769613939255 49.17785907163826 20.295577492728157 25.86086125 32.711149999999996 1.34064 18.02331574876312 33.087631089251445 13.798409693547606 80.03923750000001 78.83675 24.5771 48.248299648468354 94.38296398893532 41.505054849357066 13.8391;11.2357;5.51457;57.7663;70.3663;54.5478;64.0097;38.2177 9.31624;4.94421;1.34064;38.6865;46.0459;38.2987;41.1311;27.1236 27.6952;24.5771;39.6721;109.049;148.796;94.4701;132.851;63.2034 3 5 3 360243;78968;362282 TOP2A_10059;SREBF1_32750;PCK1_9439 10.196456666666668 11.2357 4.258458636600019 5.200363333333334 4.94421 3.993965415177419 30.648133333333334 27.6952 7.9689784604636404 13.8391;11.2357;5.51457 9.31624;4.94421;1.34064 27.6952;24.5771;39.6721 5 24516;79438;114851;24770;29657 JUN_8938;IGFALS_8880;CDKN1A_8271;CCL2_8218;ARNTL_8086 56.98155999999999 57.7663 12.115769305248474 38.25716 38.6865 6.9474135221678175 109.6739 109.049 33.387011237605584 57.7663;70.3663;54.5478;64.0097;38.2177 38.6865;46.0459;38.2987;41.1311;27.1236 109.049;148.796;94.4701;132.851;63.2034 0 Exp 2,2(0.25);Hill,2(0.25);Linear,2(0.25);Poly 2,1(0.13);Power,1(0.13) 2.0981139183449717 18.268941283226013 1.5230457782745361 4.897102355957031 1.157077599268335 1.779464840888977 21.42859160577167 57.445700894228324 13.371340640291642 38.350381859708364 46.604871635090554 113.47360336490945 DOWN 0.375 0.625 0.0 GO:0046470 6 phosphatidylcholine metabolic process 13 15 2 2 2 2 2 2 67 13 2465 0.99314 0.060519 0.060519 13.33 29692;25649 pla2g2a;apoa2 PLA2G2A_32641;APOA2_33095 40.091500000000586 40.091500000000586 1.16694E-12 56.697943035880115 61.379239768644574 48.04498949510648 25.148900000000584 25.148900000000584 1.16694E-12 35.565915458763904 38.50243475593753 30.138025175248455 98.58050000000058 98.58050000000058 1.16694E-12 139.41388008552008 150.92466348260479 118.13723824058437 0.0 1.16694E-12 0.5 40.091500000000586 1.16694E-12;80.183 1.16694E-12;50.2978 1.16694E-12;197.161 1 1 1 25649 APOA2_33095 80.183 80.183 50.2978 50.2978 197.161 197.161 80.183 50.2978 197.161 1 29692 PLA2G2A_32641 1.16694E-12 1.16694E-12 1.16694E-12 1.16694E-12 1.16694E-12 1.16694E-12 1.16694E-12 1.16694E-12 1.16694E-12 0 Hill,1(0.5);Linear,1(0.5) 1.9797962110831198 3.9596292972564697 1.9712703227996826 1.988358974456787 0.01208350146807332 1.9798146486282349 -38.487839999998265 118.67083999999943 -24.14294399999827 74.44074399999944 -94.63727999999826 291.7982799999994 CONFLICT 0.5 0.5 0.0 GO:0006725 4 cellular aromatic compound metabolic process 429 482 12 11 11 11 10 10 59 472 2006 0.21607 0.86823 0.43554 2.07 360847;360243;78968;362282;114519;293502;24516;24450;25086;29680 ube2t;top2a;srebf1;pck1;nfil3;kif22;jun;hmgcs2;cyp2e1;cyp11a1 UBE2T_10125;TOP2A_10059;SREBF1_32750;PCK1_9439;NFIL3_9304;KIF22_8963;JUN_8938;HMGCS2_8812;CYP2E1_8421;CYP11A1_32785 26.957147 22.2188 5.51457 18.60116514844885 29.755415229498347 18.57210247802924 18.183719 16.946620000000003 1.34064 13.149210139226744 20.630857482427157 12.734057457140329 46.73324 40.11885 18.2059 27.8985843930078 49.53076299188945 31.870250442784563 10.9914;13.8391;11.2357;5.51457;33.1149;13.2391;57.7663;30.5985;49.5529;43.719 7.86591;9.31624;4.94421;1.34064;25.603;9.02099;38.6865;24.577;26.9979;33.4848 18.2059;27.6952;24.5771;39.6721;46.6318;25.4349;109.049;40.5656;71.5977;63.9031 8 2 8 360847;360243;78968;362282;293502;24450;25086;29680 UBE2T_10125;TOP2A_10059;SREBF1_32750;PCK1_9439;KIF22_8963;HMGCS2_8812;CYP2E1_8421;CYP11A1_32785 22.33628375 13.539100000000001 16.716498505244058 14.693461250000002 9.168614999999999 11.85176655299892 38.956450000000004 33.68365 19.412393552720747 10.9914;13.8391;11.2357;5.51457;13.2391;30.5985;49.5529;43.719 7.86591;9.31624;4.94421;1.34064;9.02099;24.577;26.9979;33.4848 18.2059;27.6952;24.5771;39.6721;25.4349;40.5656;71.5977;63.9031 2 114519;24516 NFIL3_9304;JUN_8938 45.4406 45.4406 17.431172105742025 32.14475 32.14475 9.251431571654184 77.8404 77.8404 44.13562538267699 33.1149;57.7663 25.603;38.6865 46.6318;109.049 0 Exp 2,3(0.3);Hill,2(0.2);Linear,1(0.1);Poly 2,4(0.4) 2.2056831719198375 22.760575652122498 1.5230457782745361 3.3687045574188232 0.6040288642085242 2.274234652519226 15.428025395599688 38.48626860440031 10.033754119461296 26.33368388053871 29.441518245439184 64.02496175456083 UP 0.8 0.2 0.0 GO:0051223 7 regulation of protein transport 189 204 8 8 7 7 6 6 63 198 2280 0.6864 0.48045 0.82078 2.94 78968;24367;361921;24770;29657;25649 srebf1;fgg;ect2;ccl2;arntl;apoa2 SREBF1_32750;FGG_8639;ECT2_8523;CCL2_8218;ARNTL_8086;APOA2_33095 50.20711666666667 51.113699999999994 11.2357 34.29166131405225 53.948873584263296 30.793939078215764 30.73784333333333 34.12735 4.94421 20.201407413095428 34.10760951125402 18.286051329235775 129.20763333333332 98.0272 24.5771 117.50213208487185 129.08321546056365 98.8536980043102 11.2357;93.1824;14.4142;64.0097;38.2177;80.183 4.94421;51.338;9.59235;41.1311;27.1236;50.2978 24.5771;327.378;30.0753;132.851;63.2034;197.161 3 3 3 78968;361921;25649 SREBF1_32750;ECT2_8523;APOA2_33095 35.277633333333334 14.4142 38.92164798879068 21.611453333333333 9.59235 24.951576406612737 83.9378 30.0753 98.09269755945138 11.2357;14.4142;80.183 4.94421;9.59235;50.2978 24.5771;30.0753;197.161 3 24367;24770;29657 FGG_8639;CCL2_8218;ARNTL_8086 65.1366 64.0097 27.499672529504803 39.86423333333334 41.1311 12.156809005793127 174.47746666666663 132.851 136.9183218807963 93.1824;64.0097;38.2177 51.338;41.1311;27.1236 327.378;132.851;63.2034 0 Exp 2,2(0.34);Hill,1(0.17);Linear,1(0.17);Poly 2,1(0.17);Power,1(0.17) 2.295198038920983 14.974426031112671 1.559963583946228 4.897102355957031 1.2573855840441734 1.9400842785835266 22.768072933756553 77.64616039957679 14.573350852267307 46.902335814399365 35.18634601629773 223.2289206503689 CONFLICT 0.5 0.5 0.0 GO:0006974 5 cellular response to DNA damage stimulus 142 151 7 7 7 7 7 7 62 144 2334 0.95133 0.111 0.18709 4.64 360847;360243;299923;293502;299691;114851;58919 ube2t;top2a;ndrg1;kif22;cry1;cdkn1a;ccnd1 UBE2T_10125;TOP2A_10059;NDRG1_32364;KIF22_8963;CRY1_8386;CDKN1A_8271;CCND1_8224 36.82882857142857 28.2655 10.9914 31.854672501100694 46.26860182098035 33.1995947351555 21.60662 21.8798 7.86591 14.237693788994292 26.293820468387405 13.928033098081245 54.7677 38.3337 18.2059 35.833367395813276 66.90259883968744 35.38975275419414 10.9914;13.8391;99.6641;13.2391;37.2548;54.5478;28.2655 7.86591;9.31624;42.5546;9.02099;21.8798;38.2987;22.3101 18.2059;27.6952;105.409;25.4349;73.8251;94.4701;38.3337 4 3 4 360847;360243;293502;58919 UBE2T_10125;TOP2A_10059;KIF22_8963;CCND1_8224 16.583775 13.539100000000001 7.883684604453687 12.128309999999999 9.168614999999999 6.8166481653717925 27.417425 26.56505 8.327160721148184 10.9914;13.8391;13.2391;28.2655 7.86591;9.31624;9.02099;22.3101 18.2059;27.6952;25.4349;38.3337 3 299923;299691;114851 NDRG1_32364;CRY1_8386;CDKN1A_8271 63.82223333333334 54.5478 32.22175533491826 34.24436666666667 38.2987 10.91741969713232 91.23473333333334 94.4701 16.03859042756978 99.6641;37.2548;54.5478 42.5546;21.8798;38.2987 105.409;73.8251;94.4701 0 Exp 2,1(0.15);Exp 3,1(0.15);Linear,2(0.29);Poly 2,3(0.43) 1.8615733121298452 13.191628217697144 1.5226441621780396 2.363434076309204 0.3234427185561126 1.8622472286224365 13.230556942098886 60.42710020075826 11.059188837545006 32.15405116245499 28.221969945147013 81.313430054853 CONFLICT 0.5714285714285714 0.42857142857142855 0.0 GO:0009749 8 response to glucose 89 93 5 4 5 4 4 4 65 89 2389 0.89513 0.24305 0.31717 4.3 78968;362282;24770;25649 srebf1;pck1;ccl2;apoa2 SREBF1_32750;PCK1_9439;CCL2_8218;APOA2_33095 40.2357425 37.622699999999995 5.51457 37.450174551260666 61.095185526527885 33.275115335350435 24.4284375 23.037655 1.34064 24.905717987496203 38.03391578979181 21.897778675198506 98.56530000000001 86.26155 24.5771 81.32093627199167 147.6136662189389 78.01340040256231 11.2357;5.51457;64.0097;80.183 4.94421;1.34064;41.1311;50.2978 24.5771;39.6721;132.851;197.161 3 1 3 78968;362282;25649 SREBF1_32750;PCK1_9439;APOA2_33095 32.31109 11.2357 41.556860533554506 18.860883333333334 4.94421 27.284725146433736 87.13673333333334 39.6721 95.582264034199 11.2357;5.51457;80.183 4.94421;1.34064;50.2978 24.5771;39.6721;197.161 1 24770 CCL2_8218 64.0097 64.0097 41.1311 41.1311 132.851 132.851 64.0097 41.1311 132.851 0 Exp 2,1(0.25);Hill,2(0.5);Linear,1(0.25) 2.130540659237533 8.73355519771576 1.559963583946228 2.857419490814209 0.5519834145335134 2.158086061477661 3.534571439764555 76.93691356023544 0.020833872253724905 48.83604112774628 18.87078245344813 178.25981754655186 UP 0.75 0.25 0.0 GO:0007584 4 response to nutrient 144 154 10 10 10 6 6 6 63 148 2330 0.88009 0.23593 0.30684 3.9 25044;24450;81660;29680;58919;24770 sds;hmgcs2;gatm;cyp11a1;ccnd1;ccl2 SDS_9798;HMGCS2_8812;GATM_32792;CYP11A1_32785;CCND1_8224;CCL2_8218 44.792516666666664 40.571 28.2655 16.107469651986534 41.022691695347355 14.998474790832447 32.15981666666667 30.7574 22.3101 8.726231166641549 29.97359944869343 8.256501621133546 76.35711666666667 59.7822 38.3337 42.5419819883097 67.07126082217972 38.75454546121137 64.7394;30.5985;37.423;43.719;28.2655;64.0097 43.4259;24.577;28.03;33.4848;22.3101;41.1311 126.828;40.5656;55.6613;63.9031;38.3337;132.851 3 3 3 24450;29680;58919 HMGCS2_8812;CYP11A1_32785;CCND1_8224 34.19433333333333 30.5985 8.330676958286967 26.790633333333336 24.577 5.9070812947963685 47.6008 40.5656 14.162241467013603 30.5985;43.719;28.2655 24.577;33.4848;22.3101 40.5656;63.9031;38.3337 3 25044;81660;24770 SDS_9798;GATM_32792;CCL2_8218 55.3907 64.0097 15.564761417702478 37.529 41.1311 8.306008518536464 105.11343333333333 126.828 42.9325546719891 64.7394;37.423;64.0097 43.4259;28.03;41.1311 126.828;55.6613;132.851 0 Exp 2,4(0.67);Linear,2(0.34) 2.106866515812749 13.050300002098083 1.559963583946228 3.3687045574188232 0.6412784258070291 2.0506486892700195 31.903856646387446 57.68117668694588 25.17737751295782 39.14225582037551 42.31644148410975 110.39779184922355 CONFLICT 0.5 0.5 0.0 GO:0043086 5 negative regulation of catalytic activity 212 228 7 7 7 6 6 6 63 222 2256 0.57651 0.59334 1.0 2.63 84386;85430;116663;114851;25649;29339 slpi;herpud1;dusp6;cdkn1a;apoa2;apcs SLPI_9890;HERPUD1_8795;DUSP6_8506;CDKN1A_8271;APOA2_33095;APCS_8057 65.44081666666666 55.533550000000005 45.5478 21.344226292692507 67.01721564591432 21.683474933367485 42.94821666666667 38.8151 33.3115 9.469592655952363 43.67136451553553 9.623500986989496 158.62571666666665 97.28905 71.7388 124.1719917425249 166.09784737701526 126.21912310946155 56.5193;53.893;45.5478;54.5478;80.183;101.954 39.3315;37.9512;33.3115;38.2987;50.2978;58.4986 100.108;92.6554;71.7388;94.4701;197.161;395.621 2 4 2 85430;25649 HERPUD1_8795;APOA2_33095 67.03800000000001 67.03800000000001 18.58983727739426 44.1245 44.1245 8.73036458459786 144.9082 144.9082 73.89661843196888 53.893;80.183 37.9512;50.2978 92.6554;197.161 4 84386;116663;114851;29339 SLPI_9890;DUSP6_8506;CDKN1A_8271;APCS_8057 64.642225 55.533550000000005 25.328804066829385 42.360075 38.8151 11.075434259770566 165.484475 97.28905 153.91360851718895 56.5193;45.5478;54.5478;101.954 39.3315;33.3115;38.2987;58.4986 100.108;71.7388;94.4701;395.621 0 Linear,6(1) 1.6501691320240215 9.937379837036133 1.5270863771438599 1.9712703227996826 0.16143833440427302 1.6034149527549744 48.36187863194618 82.51975470138717 35.370964440830534 50.5254688925028 59.267430096004446 257.9840032373289 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0006355 7 regulation of transcription, DNA-templated 466 499 20 20 18 19 17 17 52 482 1996 0.88743 0.17816 0.28283 3.41 360243;24825;78968;360918;362282;316351;114519;366960;290350;24516;24309;299691;498709;306575;58919;282840;29657 top2a;tf;srebf1;pf4;pck1;npas2;nfil3;maff;loxl2;jun;dbp;cry1;cks2;ckap2;ccnd1;atf5;arntl TOP2A_10059;TF_10003;SREBF1_32750;PF4_32963;PCK1_9439;NPAS2_9350;NFIL3_9304;MAFF_9172;LOXL2_9150;JUN_8938;DBP_8439;CRY1_8386;CKS2_8325;CKAP2_8324;CCND1_8224;ATF5_8097;ARNTL_8086 43.49280411764706 38.2177 5.51457 29.23900135831272 49.99761587670956 25.788517990709963 29.132201764705886 27.1236 1.34064 19.470237895443848 34.343101133328844 18.749231226897333 69.25048235294119 63.2034 21.3803 36.65591784516575 80.17071513575422 33.91169783075212 13.8391;51.412;11.2357;105.82;5.51457;58.2312;33.1149;58.0695;65.4434;57.7663;50.6952;37.2548;14.4197;12.1218;28.2655;97.9563;38.2177 9.31624;36.6131;4.94421;53.8521;1.34064;35.795;25.603;40.1293;43.7615;38.6865;40.5862;21.8798;9.6236;8.47044;22.3101;75.2121;27.1236 27.6952;86.0232;24.5771;109.875;39.6721;99.4319;46.6318;104.733;129.393;109.049;59.5346;73.8251;29.0958;21.3803;38.3337;114.804;63.2034 8 9 8 360243;24825;78968;362282;366960;498709;306575;58919 TOP2A_10059;TF_10003;SREBF1_32750;PCK1_9439;MAFF_9172;CKS2_8325;CKAP2_8324;CCND1_8224 24.35973375 14.1294 19.892798217473388 16.593453750000002 9.46992 14.751637196827572 46.4388 33.71475 31.246905883394504 13.8391;51.412;11.2357;5.51457;58.0695;14.4197;12.1218;28.2655 9.31624;36.6131;4.94421;1.34064;40.1293;9.6236;8.47044;22.3101 27.6952;86.0232;24.5771;39.6721;104.733;29.0958;21.3803;38.3337 9 360918;316351;114519;290350;24516;24309;299691;282840;29657 PF4_32963;NPAS2_9350;NFIL3_9304;LOXL2_9150;JUN_8938;DBP_8439;CRY1_8386;ATF5_8097;ARNTL_8086 60.49997777777779 57.7663 25.92501833113033 40.27775555555556 38.6865 16.455983263779107 89.52753333333334 99.4319 29.155842330097443 105.82;58.2312;33.1149;65.4434;57.7663;50.6952;37.2548;97.9563;38.2177 53.8521;35.795;25.603;43.7615;38.6865;40.5862;21.8798;75.2121;27.1236 109.875;99.4319;46.6318;129.393;109.049;59.5346;73.8251;114.804;63.2034 0 Exp 2,2(0.12);Exp 3,1(0.06);Hill,2(0.12);Linear,5(0.3);Poly 2,5(0.3);Power,2(0.12) 2.400511009096172 44.54449474811554 1.5230457782745361 5.737884044647217 1.279481014949162 2.1833057403564453 29.593465156688993 57.39214307860513 19.876638182253842 38.387765347157924 51.82536509905997 86.67559960682237 CONFLICT 0.47058823529411764 0.5294117647058824 0.0 GO:0015718 8 monocarboxylic acid transport 51 54 2 2 2 2 2 2 67 52 2426 0.82149 0.43344 0.6568 3.7 24777;29692 slc10a1;pla2g2a SLC10A1_9832;PLA2G2A_32641 3.9838100000005836 3.9838100000005836 1.16694E-12 5.633958131916735 4.857284315098924 5.496869061012613 3.0376250000005833 3.0376250000005833 1.16694E-12 4.295850472402748 3.70364256017551 4.191321092486256 5.7431500000005835 5.7431500000005835 1.16694E-12 8.122040620742215 7.002370196936999 7.9244099361555875 7.96762;1.16694E-12 6.07525;1.16694E-12 11.4863;1.16694E-12 0 2 0 2 24777;29692 SLC10A1_9832;PLA2G2A_32641 3.9838100000005836 3.9838100000005836 5.633958131916735 3.0376250000005833 3.0376250000005833 4.295850472402748 5.7431500000005835 5.7431500000005835 8.122040620742215 7.96762;1.16694E-12 6.07525;1.16694E-12 11.4863;1.16694E-12 0 Hill,1(0.5);Poly 2,1(0.5) 2.2084647844617056 4.4412946701049805 1.988358974456787 2.4529356956481934 0.3285053499358554 2.2206473350524902 -3.824457599998273 11.792077599999441 -2.9161199999982723 8.991369999999439 -5.513423999998271 16.99972399999944 DOWN 0.0 1.0 0.0 GO:0022408 7 negative regulation of cell-cell adhesion 60 62 3 3 2 2 2 2 67 60 2418 0.76494 0.50588 0.68427 3.23 29692;24367 pla2g2a;fgg PLA2G2A_32641;FGG_8639 46.59120000000058 46.59120000000058 1.16694E-12 65.88990692723652 41.895665651995714 65.55443348281872 25.669000000000583 25.669000000000583 1.16694E-12 36.301447932554154 23.082037844509077 36.11662187431224 163.6890000000006 163.6890000000006 1.16694E-12 231.4912038112887 147.19216536404835 230.31258397227822 1.16694E-12;93.1824 1.16694E-12;51.338 1.16694E-12;327.378 0 2 0 2 29692;24367 PLA2G2A_32641;FGG_8639 46.59120000000058 46.59120000000058 65.88990692723652 25.669000000000583 25.669000000000583 36.301447932554154 163.6890000000006 163.6890000000006 231.4912038112887 1.16694E-12;93.1824 1.16694E-12;51.338 1.16694E-12;327.378 0 Exp 2,1(0.5);Hill,1(0.5) 1.9482235332807878 3.8972572088241577 1.9088982343673706 1.988358974456787 0.05618722815532816 1.9486286044120789 -44.72755199999827 137.90995199999944 -24.64223999999827 75.98023999999944 -157.1414399999982 484.51943999999935 DOWN 0.0 1.0 0.0 GO:0030335 7 positive regulation of cell migration 186 194 8 8 6 4 4 4 65 190 2288 0.38577 0.78409 0.81671 2.06 314654;24516;24770;287562 myo1f;jun;ccl2;ccl12 MYO1F_32715;JUN_8938;CCL2_8218;CCL12_8217 59.815625 60.888 25.5289 27.267050116624283 50.05004845250303 28.546302294787907 38.727000000000004 39.9088 13.9582 19.332768188923858 31.810866784748768 20.445128382420123 172.36725 121.779 109.049 110.19867513533606 214.28976885429293 127.54210240561878 91.9576;57.7663;64.0097;25.5289 61.1322;38.6865;41.1311;13.9582 110.707;109.049;132.851;336.862 1 3 1 314654 MYO1F_32715 91.9576 91.9576 61.1322 61.1322 110.707 110.707 91.9576 61.1322 110.707 3 24516;24770;287562 JUN_8938;CCL2_8218;CCL12_8217 49.101633333333325 57.7663 20.651884381172934 31.2586 38.6865 15.032361671074838 192.92066666666668 132.851 125.22365743873375 57.7663;64.0097;25.5289 38.6865;41.1311;13.9582 109.049;132.851;336.862 0 Exp 2,2(0.5);Poly 2,2(0.5) 1.5500092865159092 6.200837850570679 1.5230457782745361 1.5863633155822754 0.028818154672323727 1.5457143783569336 33.093915885708206 86.53733411429181 19.78088717485461 57.673112825145395 64.37254836737067 280.36195163262937 DOWN 0.25 0.75 0.0 GO:0032526 5 response to retinoic acid 42 45 4 4 4 4 4 4 65 41 2437 0.99336 0.031896 0.031896 8.89 78968;362282;58827;24770 srebf1;pck1;mest;ccl2 SREBF1_32750;PCK1_9439;MEST_9219;CCL2_8218 44.4192925 37.622699999999995 5.51457 43.79704176426636 58.962234453048424 43.27512294555235 26.0378125 23.037655 1.34064 27.23376251575163 34.95211548813958 26.466528525002733 132.14805 86.26155 24.5771 141.2584099592068 178.13313850225447 150.7367577163305 1.5 37.622699999999995 11.2357;5.51457;96.9172;64.0097 4.94421;1.34064;56.7353;41.1311 24.5771;39.6721;331.492;132.851 2 2 2 78968;362282 SREBF1_32750;PCK1_9439 8.375135 8.375135 4.045449819049792 3.1424250000000002 3.1424250000000002 2.548108783480407 32.1246 32.1246 10.673776862010929 11.2357;5.51457 4.94421;1.34064 24.5771;39.6721 2 58827;24770 MEST_9219;CCL2_8218 80.46345 80.46345 23.269116401896305 48.9332 48.9332 11.033835634991162 232.1715 232.1715 140.46039812167697 96.9172;64.0097 56.7353;41.1311 331.492;132.851 0 Exp 2,1(0.25);Hill,2(0.5);Linear,1(0.25) 2.1386543311529587 8.763755679130554 1.559963583946228 2.857419490814209 0.548309207578516 2.1731863021850586 1.498191571018964 87.34039342898103 -0.6512747654365896 52.72689976543659 -6.285191760022656 270.5812917600227 CONFLICT 0.5 0.5 0.0 GO:0045596 6 negative regulation of cell differentiation 184 195 8 8 7 8 7 7 62 188 2290 0.84644 0.27391 0.36463 3.59 360918;84032;58919;282840;289054;29657;29339 pf4;col3a1;ccnd1;atf5;aspm;arntl;apcs PF4_32963;COL3A1_8354;CCND1_8224;ATF5_8097;ASPM_8092;ARNTL_8086;APCS_8057 62.91634285714286 57.8774 10.3235 39.14622800606538 66.65252886692979 38.38952395313517 40.55415714285715 39.4215 7.4611 23.486415031662943 44.622368387542856 24.598554790336735 120.7574857142857 106.603 16.8623 127.02003535354085 145.48893470657714 148.98891634595844 105.82;57.8774;28.2655;97.9563;10.3235;38.2177;101.954 53.8521;39.4215;22.3101;75.2121;7.4611;27.1236;58.4986 109.875;106.603;38.3337;114.804;16.8623;63.2034;395.621 2 5 2 58919;289054 CCND1_8224;ASPM_8092 19.2945 19.2945 12.686909868049035 14.8856 14.8856 10.49982859383904 27.598 27.598 15.182572541568842 28.2655;10.3235 22.3101;7.4611 38.3337;16.8623 5 360918;84032;282840;29657;29339 PF4_32963;COL3A1_8354;ATF5_8097;ARNTL_8086;APCS_8057 80.36508 97.9563 30.436749303711796 50.821580000000004 53.8521 18.402270467988426 158.02128 109.875 134.41883647611294 105.82;57.8774;97.9563;38.2177;101.954 53.8521;39.4215;75.2121;27.1236;58.4986 109.875;106.603;114.804;63.2034;395.621 0 Exp 2,1(0.15);Exp 3,1(0.15);Linear,2(0.29);Poly 2,2(0.29);Power,1(0.15) 2.1231949585088716 16.149757862091064 1.5452834367752075 4.897102355957031 1.1899251879965884 1.8398383855819702 33.91641131746422 91.9162743968215 23.155177401432915 57.95313688428137 26.659726695217373 214.85524473335403 DOWN 0.2857142857142857 0.7142857142857143 0.0 GO:0006886 5 intracellular protein transport 114 122 3 3 3 3 3 3 66 119 2359 0.57679 0.65155 1.0 2.46 85430;114851;29657 herpud1;cdkn1a;arntl HERPUD1_8795;CDKN1A_8271;ARNTL_8086 48.88616666666667 53.893 38.2177 9.244962224007903 48.41124398876703 9.54255185459726 34.45783333333333 37.9512 27.1236 6.354008420149701 34.11739559158587 6.545954697019066 83.44296666666666 92.6554 63.2034 17.551448036083304 82.61972794998148 18.185559889812424 53.893;54.5478;38.2177 37.9512;38.2987;27.1236 92.6554;94.4701;63.2034 1 2 1 85430 HERPUD1_8795 53.893 53.893 37.9512 37.9512 92.6554 92.6554 53.893 37.9512 92.6554 2 114851;29657 CDKN1A_8271;ARNTL_8086 46.38275 46.38275 11.547124447454463 32.711149999999996 32.711149999999996 7.901988990437775 78.83675 78.83675 22.108895595325496 54.5478;38.2177 38.2987;27.1236 94.4701;63.2034 0 Linear,2(0.67);Power,1(0.34) 2.3175692392648615 8.088733077049255 1.5270863771438599 4.897102355957031 1.907237692366264 1.6645443439483643 38.424507066456044 59.34782626687729 27.267595928592435 41.64807073807423 63.58163349999781 103.30429983333552 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0019731 5 antibacterial humoral response 13 17 2 2 2 2 2 2 67 15 2463 0.99014 0.075732 0.075732 11.76 84386;170568 slpi;dmbt1 SLPI_9890;DMBT1_32993 39.13135 39.13135 21.7434 24.590274711865266 42.86948894365664 24.015291896640246 25.9936 25.9936 12.6557 18.862639073576094 28.861041154166983 18.421582865616585 130.2965 130.2965 100.108 42.69298612770021 123.80644179874119 41.69471613512371 0.0 21.7434 0.5 39.13135 56.5193;21.7434 39.3315;12.6557 100.108;160.485 1 1 1 170568 DMBT1_32993 21.7434 21.7434 12.6557 12.6557 160.485 160.485 21.7434 12.6557 160.485 1 84386 SLPI_9890 56.5193 56.5193 39.3315 39.3315 100.108 100.108 56.5193 39.3315 100.108 0 Linear,1(0.5);Poly 2,1(0.5) 1.591060846554405 3.182169795036316 1.5823365449905396 1.5998332500457764 0.0123720387929789 1.591084897518158 5.0509679999999975 73.211732 -0.14868399999999582 52.135884 71.12704000000001 189.46596 CONFLICT 0.5 0.5 0.0 GO:0070507 6 regulation of microtubule cytoskeleton organization 50 53 3 3 3 3 3 3 66 50 2428 0.9466 0.17174 0.17174 5.66 291441;306575;282840 ska1;ckap2;atf5 SKA1_9829;CKAP2_8324;ATF5_8097 40.66623333333333 12.1218 11.9206 49.61475510736029 66.30219155280501 50.784931727651994 30.676950000000005 8.47044 8.34831 38.56861960293757 50.607734047580784 39.47451536294936 52.410866666666664 21.3803 21.0483 54.03429347519346 80.32258401382414 55.32104861128085 1.5 55.03905 11.9206;12.1218;97.9563 8.34831;8.47044;75.2121 21.0483;21.3803;114.804 2 1 2 291441;306575 SKA1_9829;CKAP2_8324 12.0212 12.0212 0.1422698843745472 8.409375 8.409375 0.08635895118608913 21.2143 21.2143 0.23475945135346712 11.9206;12.1218 8.34831;8.47044 21.0483;21.3803 1 282840 ATF5_8097 97.9563 97.9563 75.2121 75.2121 114.804 114.804 97.9563 75.2121 114.804 0 Poly 2,3(1) 2.118950340794513 6.395626783370972 1.8263249397277832 2.385996103286743 0.28335798517121313 2.1833057403564453 -15.478147412009832 96.81061407867651 -12.967551703655438 74.32145170365544 -8.734692544746721 113.55642587808005 UP 0.6666666666666666 0.3333333333333333 0.0 GO:2001243 8 negative regulation of intrinsic apoptotic signaling pathway 39 41 3 3 3 2 2 2 67 39 2439 0.90227 0.30568 0.30568 4.88 29142;85430 vnn1;herpud1 VNN1_10157;HERPUD1_8795 37.380700000000004 37.380700000000004 20.8684 23.35191860597325 40.51418885579114 22.92759467892927 27.5353 27.5353 17.1194 14.730307044321922 29.51189360434554 14.462645023180249 59.6014 59.6014 26.5474 46.7454150906803 65.8739568599965 45.89601173169868 20.8684;53.893 17.1194;37.9512 26.5474;92.6554 2 0 2 29142;85430 VNN1_10157;HERPUD1_8795 37.380700000000004 37.380700000000004 23.35191860597325 27.5353 27.5353 14.730307044321922 59.6014 59.6014 46.7454150906803 20.8684;53.893 17.1194;37.9512 26.5474;92.6554 0 0 Exp 2,1(0.5);Linear,1(0.5) 2.0087148466509572 4.169330716133118 1.5270863771438599 2.642244338989258 0.7885357569150501 2.084665358066559 5.01659200000001 69.744808 7.120135999999999 47.950464 -5.184440000000009 124.38724 UP 1.0 0.0 0.0 GO:0007611 5 learning or memory 75 79 3 3 3 2 2 2 67 77 2401 0.63782 0.63901 1.0 2.53 24516;81660 jun;gatm JUN_8938;GATM_32792 47.59465 47.59465 37.423 14.384885381712303 44.663995604614165 13.774885011302654 33.35825 33.35825 28.03 7.535283413714467 31.823075344736147 7.215744845868022 82.35515000000001 82.35515000000001 55.6613 37.75080470195304 74.66412161893398 36.149957407005 57.7663;37.423 38.6865;28.03 109.049;55.6613 0 2 0 2 24516;81660 JUN_8938;GATM_32792 47.59465 47.59465 14.384885381712303 33.35825 33.35825 7.535283413714467 82.35515000000001 82.35515000000001 37.75080470195304 57.7663;37.423 38.6865;28.03 109.049;55.6613 0 Exp 2,2(1) 1.82354818130116 3.7063865661621094 1.5230457782745361 2.1833407878875732 0.4668990788810151 1.8531932830810547 27.658216000000007 67.53108399999999 22.914879999999997 43.80162 30.035204000000007 134.675096 DOWN 0.0 1.0 0.0 GO:0034284 6 response to monosaccharide 105 109 8 7 8 6 6 6 63 103 2375 0.97384 0.072123 0.072123 5.5 78968;362282;24450;29680;24770;25649 srebf1;pck1;hmgcs2;cyp11a1;ccl2;apoa2 SREBF1_32750;PCK1_9439;HMGCS2_8812;CYP11A1_32785;CCL2_8218;APOA2_33095 39.210078333333335 37.15875 5.51457 29.347041846421536 51.40453287371806 29.400168762482465 25.96259166666667 29.030900000000003 1.34064 19.640785951296774 34.012857626890316 17.91080949088435 83.12165 52.234350000000006 24.5771 67.78448109332254 111.74006901616548 80.10268296532438 4.5 72.09635 11.2357;5.51457;30.5985;43.719;64.0097;80.183 4.94421;1.34064;24.577;33.4848;41.1311;50.2978 24.5771;39.6721;40.5656;63.9031;132.851;197.161 5 1 5 78968;362282;24450;29680;25649 SREBF1_32750;PCK1_9439;HMGCS2_8812;CYP11A1_32785;APOA2_33095 34.250153999999995 30.5985 29.86728496158599 22.928890000000003 24.577 20.326718807109522 73.17578 40.5656 70.72140673754305 11.2357;5.51457;30.5985;43.719;80.183 4.94421;1.34064;24.577;33.4848;50.2978 24.5771;39.6721;40.5656;63.9031;197.161 1 24770 CCL2_8218 64.0097 64.0097 41.1311 41.1311 132.851 132.851 64.0097 41.1311 132.851 0 Exp 2,3(0.5);Hill,2(0.34);Linear,1(0.17) 2.225996239846337 13.855027318000793 1.559963583946228 3.3687045574188232 0.6941956297518467 2.158086061477661 15.727554191946165 62.69260247472049 10.24668978221888 41.67849355111446 28.88276888839522 137.3605311116048 UP 0.8333333333333334 0.16666666666666666 0.0 GO:0035296 6 regulation of tube diameter 54 57 3 3 3 2 2 2 67 55 2423 0.80073 0.46127 0.66659 3.51 25087;24367 kng2l1;fgg KNG2_8975;FGG_8639 83.55965 83.55965 73.9369 13.608623557325663 80.08039634929906 12.687955831936362 52.000299999999996 52.000299999999996 51.338 0.9366336423600267 52.23976477803738 0.8732673245688255 233.697 233.697 140.016 132.48494073667385 199.82518983644857 123.52190281277515 73.9369;93.1824 52.6626;51.338 140.016;327.378 1 1 1 25087 KNG2_8975 73.9369 73.9369 52.6626 52.6626 140.016 140.016 73.9369 52.6626 140.016 1 24367 FGG_8639 93.1824 93.1824 51.338 51.338 327.378 327.378 93.1824 51.338 327.378 0 Exp 2,2(1) 1.7522013425288705 3.517265558242798 1.6083673238754272 1.9088982343673706 0.21250744476502048 1.758632779121399 64.69906 102.42024 50.702192 53.298407999999995 50.08224000000004 417.31175999999994 CONFLICT 0.5 0.5 0.0 GO:0097746 6 regulation of blood vessel diameter 54 57 3 3 3 2 2 2 67 55 2423 0.80073 0.46127 0.66659 3.51 25087;24367 kng2l1;fgg KNG2_8975;FGG_8639 83.55965 83.55965 73.9369 13.608623557325663 80.08039634929906 12.687955831936362 52.000299999999996 52.000299999999996 51.338 0.9366336423600267 52.23976477803738 0.8732673245688255 233.697 233.697 140.016 132.48494073667385 199.82518983644857 123.52190281277515 73.9369;93.1824 52.6626;51.338 140.016;327.378 1 1 1 25087 KNG2_8975 73.9369 73.9369 52.6626 52.6626 140.016 140.016 73.9369 52.6626 140.016 1 24367 FGG_8639 93.1824 93.1824 51.338 51.338 327.378 327.378 93.1824 51.338 327.378 0 Exp 2,2(1) 1.7522013425288705 3.517265558242798 1.6083673238754272 1.9088982343673706 0.21250744476502048 1.758632779121399 64.69906 102.42024 50.702192 53.298407999999995 50.08224000000004 417.31175999999994 CONFLICT 0.5 0.5 0.0 GO:0061844 5 antimicrobial humoral immune response mediated by antimicrobial peptide 23 27 3 3 3 3 3 3 66 24 2454 0.99459 0.034972 0.034972 11.11 360918;170568;287562 pf4;dmbt1;ccl12 PF4_32963;DMBT1_32993;CCL12_8217 51.030766666666665 25.5289 21.7434 47.48660410582476 33.894689878856596 32.404206570309356 26.822000000000003 13.9582 12.6557 23.417810659196984 18.293529772632336 16.003081917788528 202.40733333333333 160.485 109.875 119.15907882462564 255.42549692665756 116.80671594395156 0.5 23.63615 1.5 65.67445 105.82;21.7434;25.5289 53.8521;12.6557;13.9582 109.875;160.485;336.862 1 2 1 170568 DMBT1_32993 21.7434 21.7434 12.6557 12.6557 160.485 160.485 21.7434 12.6557 160.485 2 360918;287562 PF4_32963;CCL12_8217 65.67445 65.67445 56.77438127892721 33.90515 33.90515 28.20924721797801 223.3685 223.3685 160.50404694119086 105.82;25.5289 53.8521;13.9582 109.875;336.862 0 Exp 3,1(0.34);Poly 2,2(0.67) 1.651913008007483 4.971136808395386 1.5314651727676392 1.8398383855819702 0.16195199775236324 1.5998332500457764 -2.7053845135955967 104.76691784692892 0.3222525956786306 53.32174740432137 67.56614191119391 337.2485247554728 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0007005 6 mitochondrion organization 66 71 2 2 2 2 2 2 67 69 2409 0.69811 0.58005 0.71844 2.82 286918;24516 mx2;jun MX2_9268;JUN_8938 44.7134 44.7134 31.6605 18.459588208299767 41.36701247922438 17.84263932106442 31.1427 31.1427 23.5989 10.668544271830152 29.208687008310257 10.311984502313319 77.9175 77.9175 46.786 44.026589517018024 69.93628026315791 42.55515065799302 31.6605;57.7663 23.5989;38.6865 46.786;109.049 0 2 0 2 286918;24516 MX2_9268;JUN_8938 44.7134 44.7134 18.459588208299767 31.1427 31.1427 10.668544271830152 77.9175 77.9175 44.026589517018024 31.6605;57.7663 23.5989;38.6865 46.786;109.049 0 Exp 2,2(1) 2.011471356339412 4.1795759201049805 1.5230457782745361 2.6565301418304443 0.8014944798393007 2.0897879600524902 19.129716000000002 70.297084 16.356852000000003 45.928548 16.899760000000008 138.93524 DOWN 0.0 1.0 0.0 GO:1903071 9 positive regulation of ER-associated ubiquitin-dependent protein catabolic process 3 3 1 1 1 1 1 1 68 2 2476 0.99787 0.07912 0.07912 33.33 85430 herpud1 HERPUD1_8795 53.893 53.893 53.893 53.893 37.9512 37.9512 37.9512 37.9512 92.6554 92.6554 92.6554 92.6554 0.0 53.893 0.0 53.893 53.893 37.9512 92.6554 1 0 1 85430 HERPUD1_8795 53.893 53.893 37.9512 37.9512 92.6554 92.6554 53.893 37.9512 92.6554 0 0 Linear,1(1) 1.5270863771438599 1.5270863771438599 1.5270863771438599 1.5270863771438599 0.0 1.5270863771438599 53.893 53.893 37.9512 37.9512 92.6554 92.6554 UP 1.0 0.0 0.0 GO:0046903 5 secretion 115 123 6 5 5 6 5 5 64 118 2360 0.88695 0.23832 0.38255 4.07 29692;314654;24367;58919;287562 pla2g2a;myo1f;fgg;ccnd1;ccl12 PLA2G2A_32641;MYO1F_32715;FGG_8639;CCND1_8224;CCL12_8217 47.78688000000023 28.2655 1.16694E-12 42.343516600265644 39.586809716332624 34.60871153571443 29.747700000000236 22.3101 1.16694E-12 25.6937723662755 25.062984672073906 21.781429207488777 162.65614000000022 110.707 1.16694E-12 159.75980011738844 188.9961351599491 161.8946521091145 1.16694E-12;91.9576;93.1824;28.2655;25.5289 1.16694E-12;61.1322;51.338;22.3101;13.9582 1.16694E-12;110.707;327.378;38.3337;336.862 2 3 2 314654;58919 MYO1F_32715;CCND1_8224 60.11155 60.11155 45.0371158180117 41.721149999999994 41.721149999999994 27.45137016990228 74.52035 74.52035 51.175651206848364 91.9576;28.2655 61.1322;22.3101 110.707;38.3337 3 29692;24367;287562 PLA2G2A_32641;FGG_8639;CCL12_8217 39.57043333333372 25.5289 48.15198242236023 21.765400000000387 13.9582 26.544525610377267 221.41333333333372 327.378 191.8081976802167 1.16694E-12;93.1824;25.5289 1.16694E-12;51.338;13.9582 1.16694E-12;327.378;336.862 0 Exp 2,1(0.2);Hill,1(0.2);Linear,1(0.2);Poly 2,2(0.4) 1.8368322386462848 9.282652616500854 1.5314651727676392 2.2675669193267822 0.30320366043232294 1.9088982343673706 10.671151242363003 84.90260875763747 7.226115529116353 52.2692844708841 22.620500931370543 302.6917790686299 DOWN 0.4 0.6 0.0 GO:0071900 8 regulation of protein serine/threonine kinase activity 142 154 5 5 5 5 5 5 64 149 2329 0.76407 0.40602 0.60704 3.25 24825;116663;498709;114851;58919 tf;dusp6;cks2;cdkn1a;ccnd1 TF_10003;DUSP6_8506;CKS2_8325;CDKN1A_8271;CCND1_8224 38.83856 45.5478 14.4197 17.014375081471556 42.68688637946193 14.568587477642334 28.031399999999998 33.3115 9.6236 12.026251023490252 30.867791102514506 9.869021297154243 63.932320000000004 71.7388 29.0958 28.941218824144208 69.76779277299103 26.933575528253694 51.412;45.5478;14.4197;54.5478;28.2655 36.6131;33.3115;9.6236;38.2987;22.3101 86.0232;71.7388;29.0958;94.4701;38.3337 3 2 3 24825;498709;58919 TF_10003;CKS2_8325;CCND1_8224 31.365733333333335 28.2655 18.690001333957497 22.848933333333335 22.3101 13.50281576499262 51.1509 38.3337 30.55147589839156 51.412;14.4197;28.2655 36.6131;9.6236;22.3101 86.0232;29.0958;38.3337 2 116663;114851 DUSP6_8506;CDKN1A_8271 50.0478 50.0478 6.363961030678928 35.805099999999996 35.805099999999996 3.526482939133565 83.10445 83.10445 16.073456375185824 45.5478;54.5478 33.3115;38.2987 71.7388;94.4701 0 Linear,4(0.8);Poly 2,1(0.2) 1.7856886434337624 9.035152196884155 1.530501127243042 2.2675669193267822 0.31832251484521784 1.6645443439483643 23.924802683475228 53.752317316524774 17.48992619722377 38.57287380277623 38.56422320414666 89.30041679585334 UP 0.6 0.4 0.0 GO:0048524 5 positive regulation of viral process 22 23 2 2 2 2 2 2 67 21 2457 0.97714 0.12717 0.12717 8.7 360243;24516 top2a;jun TOP2A_10059;JUN_8938 35.8027 35.8027 13.8391 31.06122099853771 46.815209731543625 26.874685277139797 24.00137 24.00137 9.31624 20.767910011212013 31.364467899888144 17.968741326735326 68.3721 68.3721 27.6952 57.525823655294154 88.76742486017898 49.77229987568922 0.5 35.8027 13.8391;57.7663 9.31624;38.6865 27.6952;109.049 1 1 1 360243 TOP2A_10059 13.8391 13.8391 9.31624 9.31624 27.6952 27.6952 13.8391 9.31624 27.6952 1 24516 JUN_8938 57.7663 57.7663 38.6865 38.6865 109.049 109.049 57.7663 38.6865 109.049 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.6985981252805318 3.417431116104126 1.5230457782745361 1.8943853378295898 0.2625767206842043 1.708715558052063 -7.2459559999999925 78.851356 -4.781484799999998 52.784224800000004 -11.354624000000001 148.098824 CONFLICT 0.5 0.5 0.0 GO:0010557 7 positive regulation of macromolecule biosynthetic process 371 401 18 18 16 17 15 15 54 386 2092 0.93489 0.11399 0.17871 3.74 360243;24825;78968;360918;362282;316351;114519;366960;24516;24309;306575;24770;282840;29657;25649 top2a;tf;srebf1;pf4;pck1;npas2;nfil3;maff;jun;dbp;ckap2;ccl2;atf5;arntl;apoa2 TOP2A_10059;TF_10003;SREBF1_32750;PF4_32963;PCK1_9439;NPAS2_9350;NFIL3_9304;MAFF_9172;JUN_8938;DBP_8439;CKAP2_8324;CCL2_8218;ATF5_8097;ARNTL_8086;APOA2_33095 49.21246466666666 51.412 5.51457 30.888330455744914 58.59538908567069 26.81397117500914 32.60675533333333 36.6131 1.34064 20.323404129523354 39.820805843559285 18.97549639900139 82.44150666666668 86.0232 21.3803 48.61531581178134 100.81414633489157 50.61716498953628 13.8391;51.412;11.2357;105.82;5.51457;58.2312;33.1149;58.0695;57.7663;50.6952;12.1218;64.0097;97.9563;38.2177;80.183 9.31624;36.6131;4.94421;53.8521;1.34064;35.795;25.603;40.1293;38.6865;40.5862;8.47044;41.1311;75.2121;27.1236;50.2978 27.6952;86.0232;24.5771;109.875;39.6721;99.4319;46.6318;104.733;109.049;59.5346;21.3803;132.851;114.804;63.2034;197.161 7 8 7 360243;24825;78968;362282;366960;306575;25649 TOP2A_10059;TF_10003;SREBF1_32750;PCK1_9439;MAFF_9172;CKAP2_8324;APOA2_33095 33.19652428571429 13.8391 29.51163513912993 21.58739 9.31624 20.01426098027854 71.60598571428572 39.6721 64.22821616624655 13.8391;51.412;11.2357;5.51457;58.0695;12.1218;80.183 9.31624;36.6131;4.94421;1.34064;40.1293;8.47044;50.2978 27.6952;86.0232;24.5771;39.6721;104.733;21.3803;197.161 8 360918;316351;114519;24516;24309;24770;282840;29657 PF4_32963;NPAS2_9350;NFIL3_9304;JUN_8938;DBP_8439;CCL2_8218;ATF5_8097;ARNTL_8086 63.2264125 57.99875 26.090303262456814 42.2487 39.63635 15.970620607674755 91.92258749999999 104.24045000000001 31.157929004643346 105.82;58.2312;33.1149;57.7663;50.6952;64.0097;97.9563;38.2177 53.8521;35.795;25.603;38.6865;40.5862;41.1311;75.2121;27.1236 109.875;99.4319;46.6318;109.049;59.5346;132.851;114.804;63.2034 0 Exp 2,2(0.14);Exp 3,1(0.07);Hill,2(0.14);Linear,4(0.27);Poly 2,4(0.27);Power,2(0.14) 2.4746497571731974 40.678067207336426 1.5230457782745361 5.737884044647217 1.3348779168461813 2.1833057403564453 33.58081271222582 64.84411662110752 22.321693784366765 42.8918168822999 57.83876235473991 107.04425097859337 CONFLICT 0.4666666666666667 0.5333333333333333 0.0 GO:0090066 4 regulation of anatomical structure size 103 112 4 4 4 3 3 3 66 109 2369 0.63949 0.59266 1.0 2.68 25087;24367;81639 kng2l1;fgg;alox15 KNG2_8975;FGG_8639;ALOX15_8036 90.91443333333332 93.1824 73.9369 15.96483107343555 92.663890509002 17.489550012472666 62.61026666666667 52.6626 51.338 18.388931978049513 67.80209742905832 19.350508670065565 198.94466666666668 140.016 129.44 111.35216108066031 165.1514751426243 87.54059990445646 73.9369;93.1824;105.624 52.6626;51.338;83.8302 140.016;327.378;129.44 2 1 2 25087;81639 KNG2_8975;ALOX15_8036 89.78045 89.78045 22.40616328613619 68.2464 68.2464 22.038821313309885 134.728 134.728 7.478361317828303 73.9369;105.624 52.6626;83.8302 140.016;129.44 1 24367 FGG_8639 93.1824 93.1824 51.338 51.338 327.378 327.378 93.1824 51.338 327.378 0 Exp 2,2(0.67);Poly 2,1(0.34) 1.7317134631051605 5.2087191343307495 1.6083673238754272 1.9088982343673706 0.15519038462594528 1.6914535760879517 72.8485262784161 108.98034038825057 41.801231204498876 83.41930212883446 72.93783432412565 324.95149900920774 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0017001 5 antibiotic catabolic process 20 22 4 4 4 4 4 4 65 18 2460 0.99977 0.0024968 0.0024968 18.18 362282;287167;24440;360504 pck1;hba-a1;hbb;hba-a2 PCK1_9439;LOC287167_9118;HBB_8782;HBA2_32600 75.8879675 96.41714999999999 5.51457 47.273876235720564 79.64703856384504 42.94803590069194 55.688485 68.3849 1.34064 38.67640868117023 56.49446616642754 34.8681887065873 140.72702500000003 123.10000000000001 39.6721 99.18974706928715 163.90266480631277 106.5447333394864 0.5 48.471435 1.5 96.41714999999999 5.51457;105.203;91.4283;101.406 1.34064;82.0435;54.7263;84.6435 39.6721;130.247;277.036;115.953 3 1 3 362282;287167;360504 PCK1_9439;LOC287167_9118;HBA2_32600 70.70785666666667 101.406 56.49095301065147 56.00921333333333 82.0435 47.36221788225857 95.29070000000002 115.953 48.6944669184292 5.51457;105.203;101.406 1.34064;82.0435;84.6435 39.6721;130.247;115.953 1 24440 HBB_8782 91.4283 91.4283 54.7263 54.7263 277.036 277.036 91.4283 54.7263 277.036 0 Hill,1(0.25);Linear,1(0.25);Poly 2,2(0.5) 1.871373253663275 7.554054260253906 1.6757243871688843 2.3449018001556396 0.30740842724823897 1.7667140364646912 29.559568788993857 122.21636621100615 17.785604492453174 93.59136550754683 43.52107287209856 237.93297712790144 UP 0.75 0.25 0.0 GO:0042981 7 regulation of apoptotic process 428 455 16 16 14 13 12 12 57 443 2035 0.53497 0.59184 1.0 2.64 29142;360243;360918;24516;85430;24367;361921;116663;114851;24770;282840;25612 vnn1;top2a;pf4;jun;herpud1;fgg;ect2;dusp6;cdkn1a;ccl2;atf5;asns VNN1_10157;TOP2A_10059;PF4_32963;JUN_8938;HERPUD1_8795;FGG_8639;ECT2_8523;DUSP6_8506;CDKN1A_8271;CCL2_8218;ATF5_8097;ASNS_8091 58.9591 56.15705 13.8391 32.085121679172005 61.455727371898284 28.298267100659004 38.2923575 38.492599999999996 9.31624 19.440979675549514 41.973871524160714 19.365222452904632 113.46893333333333 101.75955 26.5474 86.80949271398138 110.82137472535915 70.36920786657203 20.8684;13.8391;105.82;57.7663;53.893;93.1824;14.4142;45.5478;54.5478;64.0097;97.9563;85.6642 17.1194;9.31624;53.8521;38.6865;37.9512;51.338;9.59235;33.3115;38.2987;41.1311;75.2121;53.6991 26.5474;27.6952;109.875;109.049;92.6554;327.378;30.0753;71.7388;94.4701;132.851;114.804;224.488 5 7 5 29142;360243;85430;361921;25612 VNN1_10157;TOP2A_10059;HERPUD1_8795;ECT2_8523;ASNS_8091 37.73578 20.8684 31.45490867340104 25.535658 17.1194 19.592199579202944 80.29226 30.0753 85.32579099180974 20.8684;13.8391;53.893;14.4142;85.6642 17.1194;9.31624;37.9512;9.59235;53.6991 26.5474;27.6952;92.6554;30.0753;224.488 7 360918;24516;24367;116663;114851;24770;282840 PF4_32963;JUN_8938;FGG_8639;DUSP6_8506;CDKN1A_8271;CCL2_8218;ATF5_8097 74.11861428571429 64.0097 24.171393469238843 47.40428571428571 41.1311 14.301479525143398 137.16655714285713 109.875 85.96346700534781 105.82;57.7663;93.1824;45.5478;54.5478;64.0097;97.9563 53.8521;38.6865;51.338;33.3115;38.2987;41.1311;75.2121 109.875;109.049;327.378;71.7388;94.4701;132.851;114.804 0 Exp 2,5(0.42);Exp 3,1(0.09);Linear,3(0.25);Poly 2,3(0.25) 1.7962117916270315 21.88936674594879 1.5230457782745361 2.642244338989258 0.3556466901485141 1.7221581935882568 40.80523343431719 77.11296656568281 27.292587747991213 49.29212725200879 64.35183902643396 162.58602764023271 CONFLICT 0.4166666666666667 0.5833333333333334 0.0 GO:0010243 5 response to organonitrogen compound 400 420 21 21 18 19 17 17 52 403 2075 0.97323 0.051142 0.070588 4.05 24825;78968;25044;362282;24587;24516;79438;24450;81660;25086;29680;299691;84032;114851;58919;24770;25612 tf;srebf1;sds;pck1;nefh;jun;igfals;hmgcs2;gatm;cyp2e1;cyp11a1;cry1;col3a1;cdkn1a;ccnd1;ccl2;asns TF_10003;SREBF1_32750;SDS_9798;PCK1_9439;NEFH_33218;JUN_8938;IGFALS_8880;HMGCS2_8812;GATM_32792;CYP2E1_8421;CYP11A1_32785;CRY1_8386;COL3A1_8354;CDKN1A_8271;CCND1_8224;CCL2_8218;ASNS_8091 48.78031000000001 51.412 5.51457 22.0372666865148 51.224139400529886 19.91658018819883 31.783079411764707 36.6131 1.34064 13.837376738557804 33.373698897968794 11.342425986191191 100.0814705882353 86.0232 24.5771 65.38099097594962 106.91817942537534 70.34741780185733 51.412;11.2357;64.7394;5.51457;79.3182;57.7663;70.3663;30.5985;37.423;49.5529;43.719;37.2548;57.8774;54.5478;28.2655;64.0097;85.6642 36.6131;4.94421;43.4259;1.34064;39.4261;38.6865;46.0459;24.577;28.03;26.9979;33.4848;21.8798;39.4215;38.2987;22.3101;41.1311;53.6991 86.0232;24.5771;126.828;39.6721;264.141;109.049;148.796;40.5656;55.6613;71.5977;63.9031;73.8251;106.603;94.4701;38.3337;132.851;224.488 8 9 8 24825;78968;362282;24450;25086;29680;58919;25612 TF_10003;SREBF1_32750;PCK1_9439;HMGCS2_8812;CYP2E1_8421;CYP11A1_32785;CCND1_8224;ASNS_8091 38.245296249999996 37.15875 25.46321271482447 25.495856250000003 25.78745 16.911253225709064 73.6450625 52.234350000000006 64.26382885527303 51.412;11.2357;5.51457;30.5985;49.5529;43.719;28.2655;85.6642 36.6131;4.94421;1.34064;24.577;26.9979;33.4848;22.3101;53.6991 86.0232;24.5771;39.6721;40.5656;71.5977;63.9031;38.3337;224.488 9 25044;24587;24516;79438;81660;299691;84032;114851;24770 SDS_9798;NEFH_33218;JUN_8938;IGFALS_8880;GATM_32792;CRY1_8386;COL3A1_8354;CDKN1A_8271;CCL2_8218 58.14476666666667 57.8774 13.939610827691727 37.371722222222225 39.4215 7.618273783931925 123.5805 109.049 60.130064206123215 64.7394;79.3182;57.7663;70.3663;37.423;37.2548;57.8774;54.5478;64.0097 43.4259;39.4261;38.6865;46.0459;28.03;21.8798;39.4215;38.2987;41.1311 126.828;264.141;109.049;148.796;55.6613;73.8251;106.603;94.4701;132.851 0 Exp 2,9(0.53);Hill,2(0.12);Linear,5(0.3);Poly 2,1(0.06) 1.9479231957467154 33.99102056026459 1.5230457782745361 3.3687045574188232 0.5064480596518942 1.8622472286224365 38.304458390183804 59.25616160981621 25.20520805211202 38.36095077141741 69.0013203450156 131.16162083145502 CONFLICT 0.47058823529411764 0.5294117647058824 0.0 GO:0006874 9 cellular calcium ion homeostasis 113 117 3 3 3 3 3 3 66 114 2364 0.60805 0.62286 1.0 2.56 85430;24770;287562 herpud1;ccl2;ccl12 HERPUD1_8795;CCL2_8218;CCL12_8217 47.81053333333333 53.893 25.5289 19.948440859458998 38.46251810524983 20.07700890354976 31.013500000000004 37.9512 13.9582 14.855651603682691 23.943395332784497 15.258738687682524 187.45613333333336 132.851 92.6554 130.9408504274099 248.11953517826612 136.0493668510377 53.893;64.0097;25.5289 37.9512;41.1311;13.9582 92.6554;132.851;336.862 1 2 1 85430 HERPUD1_8795 53.893 53.893 37.9512 37.9512 92.6554 92.6554 53.893 37.9512 92.6554 2 24770;287562 CCL2_8218;CCL12_8217 44.7693 44.7693 27.210034625483285 27.54465 27.54465 19.214141854503943 234.8565 234.8565 144.2575615366488 64.0097;25.5289 41.1311;13.9582 132.851;336.862 0 Exp 2,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 1.5394363223875356 4.618515133857727 1.5270863771438599 1.559963583946228 0.017852376209459397 1.5314651727676392 25.236747441094245 70.38431922557243 14.202747673347947 47.82425232665206 39.282612258653415 335.62965440801327 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0017144 4 drug metabolic process 142 165 14 14 13 13 12 12 57 153 2325 0.99965 0.0012563 0.0012563 7.27 287877;362282;287167;24450;24440;360504;81660;24306;25086;499353;29680;25612 pycr1;pck1;hba-a1;hmgcs2;hbb;hba-a2;gatm;cyp4a2;cyp2e1;cyp2c24;cyp11a1;asns PYCR1_9631;PCK1_9439;LOC287167_9118;HMGCS2_8812;HBB_8782;HBA2_32600;GATM_32792;CYP4A2_8425;CYP2E1_8421;CYP2C24_32875;CYP11A1_32785;ASNS_8091 56.27948916666666 52.13255 5.51457 33.61148678029784 50.474614501868736 27.195564344245707 39.9151775 35.935199999999995 1.34064 25.785879576962323 35.50759269777311 19.02082754366766 102.55766666666669 83.26400000000001 17.0471 77.50920194529789 93.36410553414315 72.04984597499619 7.5 72.61565 54.7122;5.51457;105.203;30.5985;91.4283;101.406;37.423;59.5671;49.5529;10.5651;43.719;85.6642 38.3856;1.34064;82.0435;24.577;54.7263;84.6435;28.03;43.4174;26.9979;7.63639;33.4848;53.6991 94.9303;39.6721;130.247;40.5656;277.036;115.953;55.6613;99.5908;71.5977;17.0471;63.9031;224.488 9 3 9 287877;362282;287167;24450;360504;24306;25086;29680;25612 PYCR1_9631;PCK1_9439;LOC287167_9118;HMGCS2_8812;HBA2_32600;CYP4A2_8425;CYP2E1_8421;CYP11A1_32785;ASNS_8091 59.54860777777779 54.7122 32.882474031371075 43.17660444444445 38.3856 26.96235424930801 97.88306666666669 94.9303 56.936102629131504 54.7122;5.51457;105.203;30.5985;101.406;59.5671;49.5529;43.719;85.6642 38.3856;1.34064;82.0435;24.577;84.6435;43.4174;26.9979;33.4848;53.6991 94.9303;39.6721;130.247;40.5656;115.953;99.5908;71.5977;63.9031;224.488 3 24440;81660;499353 HBB_8782;GATM_32792;CYP2C24_32875 46.47213333333334 37.423 41.184091456815366 30.13089666666667 28.03 23.615148338620134 116.58146666666666 55.6613 140.2925766418998 91.4283;37.423;10.5651 54.7263;28.03;7.63639 277.036;55.6613;17.0471 0 Exp 2,5(0.42);Hill,1(0.09);Linear,2(0.17);Poly 2,4(0.34) 1.9980867979815593 24.524190306663513 1.5959433317184448 3.3687045574188232 0.49454267600079355 1.8465972542762756 37.26200024500754 75.2969780883258 25.325442675250542 54.504912324749455 58.70270723103169 146.41262610230166 UP 0.75 0.25 0.0 GO:0036345 5 platelet maturation 1 1 1 1 1 1 1 1 68 0 2478 1.0 0.027091 0.027091 100.0 24367 fgg FGG_8639 93.1824 93.1824 93.1824 93.18240000000002 51.338 51.338 51.338 51.33800000000001 327.378 327.378 327.378 327.378 0.0 93.1824 0.0 93.1824 93.1824 51.338 327.378 0 1 0 1 24367 FGG_8639 93.1824 93.1824 51.338 51.338 327.378 327.378 93.1824 51.338 327.378 0 Exp 2,1(1) 1.9088982343673706 1.9088982343673706 1.9088982343673706 1.9088982343673706 0.0 1.9088982343673706 93.1824 93.1824 51.338 51.338 327.378 327.378 DOWN 0.0 1.0 0.0 GO:0000226 5 microtubule cytoskeleton organization 73 80 6 6 6 3 3 3 66 77 2401 0.83072 0.36969 0.47696 3.75 24587;303575;289054 nefh;kif18b;aspm NEFH_33218;KIF18B_32882;ASPM_8092 31.106166666666667 10.3235 3.6768 41.88489911439842 47.52541997216933 44.2043198174507 16.002513333333333 7.4611 1.12034 20.531673545829946 23.91865710268053 21.673229854357 97.58406666666667 16.8623 11.7489 144.2651924268059 154.65759496118355 151.95797652589377 79.3182;3.6768;10.3235 39.4261;1.12034;7.4611 264.141;11.7489;16.8623 2 1 2 303575;289054 KIF18B_32882;ASPM_8092 7.00015 7.00015 4.699926642512625 4.29072 4.29072 4.483594393876412 14.305600000000002 14.305600000000002 3.615719814919288 3.6768;10.3235 1.12034;7.4611 11.7489;16.8623 1 24587 NEFH_33218 79.3182 79.3182 39.4261 39.4261 264.141 264.141 79.3182 39.4261 264.141 0 Exp 2,1(0.34);Exp 4,1(0.34);Poly 2,1(0.34) 1.7217031170248465 5.181366920471191 1.5452834367752075 1.8689792156219482 0.16551029342571175 1.7671042680740356 -16.2910585795427 78.50339191287603 -7.231262473919603 39.236289140586265 -65.66736679066008 260.8355001239934 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0006629 4 lipid metabolic process 289 320 18 17 16 16 13 13 56 307 2171 0.95606 0.084114 0.13708 4.06 78968;83792;29692;362282;24450;171142;29740;24306;25086;499353;29680;25649;81639 srebf1;scd2;pla2g2a;pck1;hmgcs2;ehhadh;eci1;cyp4a2;cyp2e1;cyp2c24;cyp11a1;apoa2;alox15 SREBF1_32750;SCD_9786;PLA2G2A_32641;PCK1_9439;HMGCS2_8812;EHHADH_8534;ECI1_8520;CYP4A2_8425;CYP2E1_8421;CYP2C24_32875;CYP11A1_32785;APOA2_33095;ALOX15_8036 47.42191307692316 43.719 1.16694E-12 36.80109261104052 57.28567868376777 35.77547194795926 31.258480000000084 26.9979 1.16694E-12 24.7876757829883 38.78867147536881 24.857874941403075 80.15636153846164 63.9031 1.16694E-12 65.43776796995152 100.28785599133617 71.11076926997522 11.2357;83.9984;1.16694E-12;5.51457;30.5985;32.6956;103.231;59.5671;49.5529;10.5651;43.719;80.183;105.624 4.94421;54.1928;1.16694E-12;1.34064;24.577;25.6436;49.9975;43.4174;26.9979;7.63639;33.4848;50.2978;83.8302 24.5771;206.18;1.16694E-12;39.6721;40.5656;45.0542;107.244;99.5908;71.5977;17.0471;63.9031;197.161;129.44 11 2 11 78968;83792;362282;24450;171142;29740;24306;25086;29680;25649;81639 SREBF1_32750;SCD_9786;PCK1_9439;HMGCS2_8812;EHHADH_8534;ECI1_8520;CYP4A2_8425;CYP2E1_8421;CYP11A1_32785;APOA2_33095;ALOX15_8036 55.08361545454545 49.5529 34.639376411503534 36.24762272727273 33.4848 23.58864927058779 93.18050909090911 71.5977 62.53917485985011 11.2357;83.9984;5.51457;30.5985;32.6956;103.231;59.5671;49.5529;43.719;80.183;105.624 4.94421;54.1928;1.34064;24.577;25.6436;49.9975;43.4174;26.9979;33.4848;50.2978;83.8302 24.5771;206.18;39.6721;40.5656;45.0542;107.244;99.5908;71.5977;63.9031;197.161;129.44 2 29692;499353 PLA2G2A_32641;CYP2C24_32875 5.282550000000583 5.282550000000583 7.470653853913168 3.8181950000005833 3.8181950000005833 5.399743152784314 8.523550000000583 8.523550000000583 12.05412000956437 1.16694E-12;10.5651 1.16694E-12;7.63639 1.16694E-12;17.0471 0 Exp 2,5(0.39);Exp 3,1(0.08);Hill,3(0.24);Linear,1(0.08);Poly 2,3(0.24) 2.083691883662393 27.69173777103424 1.618504285812378 3.3687045574188232 0.49944284316336934 1.9712703227996826 27.416611250129105 67.42721490371723 17.783745951624947 44.73321404837523 44.58398565965797 115.72873741726531 UP 0.8461538461538461 0.15384615384615385 0.0 GO:0051241 5 negative regulation of multicellular organismal process 326 344 14 14 12 12 11 11 58 333 2145 0.78685 0.32451 0.5906 3.2 360918;290350;24367;299691;84032;24770;282840;289054;29657;25649;29339 pf4;loxl2;fgg;cry1;col3a1;ccl2;atf5;aspm;arntl;apoa2;apcs PF4_32963;LOXL2_9150;FGG_8639;CRY1_8386;COL3A1_8354;CCL2_8218;ATF5_8097;ASPM_8092;ARNTL_8086;APOA2_33095;APCS_8057 68.38383636363636 65.4434 10.3235 30.895503956960255 69.0834724928664 29.302928560527256 42.7252 43.7615 7.4611 18.696411944809075 44.41072952702119 19.437743351046457 151.5978909090909 114.804 16.8623 114.23722128095076 158.2590149969736 117.27464370007635 105.82;65.4434;93.1824;37.2548;57.8774;64.0097;97.9563;10.3235;38.2177;80.183;101.954 53.8521;43.7615;51.338;21.8798;39.4215;41.1311;75.2121;7.4611;27.1236;50.2978;58.4986 109.875;129.393;327.378;73.8251;106.603;132.851;114.804;16.8623;63.2034;197.161;395.621 2 9 2 289054;25649 ASPM_8092;APOA2_33095 45.25325 45.25325 49.39812618030163 28.879450000000002 28.879450000000002 30.29012105365378 107.01165 107.01165 127.49043340911898 10.3235;80.183 7.4611;50.2978 16.8623;197.161 9 360918;290350;24367;299691;84032;24770;282840;29657;29339 PF4_32963;LOXL2_9150;FGG_8639;CRY1_8386;COL3A1_8354;CCL2_8218;ATF5_8097;ARNTL_8086;APCS_8057 73.52396666666667 65.4434 26.919579933990438 45.802033333333334 43.7615 16.238284416310748 161.50594444444445 114.804 116.93386227294377 105.82;65.4434;93.1824;37.2548;57.8774;64.0097;97.9563;38.2177;101.954 53.8521;43.7615;51.338;21.8798;39.4215;41.1311;75.2121;27.1236;58.4986 109.875;129.393;327.378;73.8251;106.603;132.851;114.804;63.2034;395.621 0 Exp 2,4(0.37);Exp 3,1(0.1);Linear,3(0.28);Poly 2,2(0.19);Power,1(0.1) 1.9588184830112905 22.921916484832764 1.5452834367752075 4.897102355957031 0.964240713714927 1.8398383855819702 50.125760282273795 86.64191244499892 31.676326603652058 53.77407339634793 84.08800725816683 219.10777456001495 DOWN 0.18181818181818182 0.8181818181818182 0.0 GO:0071345 6 cellular response to cytokine stimulus 172 189 10 10 10 10 10 10 59 179 2299 0.98871 0.028703 0.033241 5.29 362282;114519;24587;286918;79438;24367;29680;24770;287562;81639 pck1;nfil3;nefh;mx2;igfals;fgg;cyp11a1;ccl2;ccl12;alox15 PCK1_9439;NFIL3_9304;NEFH_33218;MX2_9268;IGFALS_8880;FGG_8639;CYP11A1_32785;CCL2_8218;CCL12_8217;ALOX15_8036 55.203846999999996 53.86435 5.51457 32.31313212842387 56.414381376929946 31.195497521026702 35.975684 36.45545 1.34064 22.6502051074624 36.88977699179404 23.06527836064991 153.6461 131.1455 39.6721 115.91034708350148 174.23929128650877 117.80671791769358 8.5 99.4032 5.51457;33.1149;79.3182;31.6605;70.3663;93.1824;43.719;64.0097;25.5289;105.624 1.34064;25.603;39.4261;23.5989;46.0459;51.338;33.4848;41.1311;13.9582;83.8302 39.6721;46.6318;264.141;46.786;148.796;327.378;63.9031;132.851;336.862;129.44 3 7 3 362282;29680;81639 PCK1_9439;CYP11A1_32785;ALOX15_8036 51.61919 43.719 50.520137027311186 39.551880000000004 33.4848 41.5781068838301 77.67173333333334 63.9031 46.44082703293875 5.51457;43.719;105.624 1.34064;33.4848;83.8302 39.6721;63.9031;129.44 7 114519;24587;286918;79438;24367;24770;287562 NFIL3_9304;NEFH_33218;MX2_9268;IGFALS_8880;FGG_8639;CCL2_8218;CCL12_8217 56.74012857142856 64.0097 26.57570211093299 34.44302857142857 39.4261 13.570786126052088 186.20654285714286 148.796 123.7374815039062 33.1149;79.3182;31.6605;70.3663;93.1824;64.0097;25.5289 25.603;39.4261;23.5989;46.0459;51.338;41.1311;13.9582 46.6318;264.141;46.786;148.796;327.378;132.851;336.862 0 Exp 2,5(0.5);Hill,1(0.1);Linear,2(0.2);Poly 2,2(0.2) 1.9095587373779037 19.57620632648468 1.527578592300415 2.835543394088745 0.4813598076841373 1.7599359154701233 35.17596021148235 75.23173378851764 21.936941428526232 50.01442657147377 81.8041225717541 225.48807742824587 DOWN 0.3 0.7 0.0 GO:0018958 5 phenol-containing compound metabolic process 27 31 2 2 2 2 2 2 67 29 2449 0.95021 0.20433 0.20433 6.45 25086;29680 cyp2e1;cyp11a1 CYP2E1_8421;CYP11A1_32785 46.63595 46.63595 43.719 4.125190250764143 47.181539352051836 4.052389310376797 30.24135 30.24135 26.9979 4.586930978879031 29.634691749460043 4.50598128481509 67.7504 67.7504 63.9031 5.440903838518165 68.47000298056156 5.344883317784602 0.5 46.63595 49.5529;43.719 26.9979;33.4848 71.5977;63.9031 2 0 2 25086;29680 CYP2E1_8421;CYP11A1_32785 46.63595 46.63595 4.125190250764143 30.24135 30.24135 4.586930978879031 67.7504 67.7504 5.440903838518165 49.5529;43.719 26.9979;33.4848 71.5977;63.9031 0 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.965284113085084 3.9563350677490234 1.752767562866211 2.2035675048828125 0.3187636959584414 1.9781675338745117 40.918728 52.353172 23.884188 36.598512 60.209692 75.291108 UP 1.0 0.0 0.0 GO:0019395 7 fatty acid oxidation 39 43 3 3 3 3 3 3 66 40 2438 0.9725 0.10897 0.10897 6.98 171142;29740;81639 ehhadh;eci1;alox15 EHHADH_8534;ECI1_8520;ALOX15_8036 80.51686666666667 103.231 32.6956 41.43171214725904 88.69351215477997 36.78537119514521 53.15709999999999 49.9975 25.6436 29.221694150237102 61.6290970030349 29.356818624732853 93.91273333333334 107.244 45.0542 43.743946022430734 104.55953963581182 40.70573489219625 1.5 104.4275 32.6956;103.231;105.624 25.6436;49.9975;83.8302 45.0542;107.244;129.44 3 0 3 171142;29740;81639 EHHADH_8534;ECI1_8520;ALOX15_8036 80.51686666666667 103.231 41.43171214725904 53.15709999999999 49.9975 29.221694150237102 93.91273333333334 107.244 43.743946022430734 32.6956;103.231;105.624 25.6436;49.9975;83.8302 45.0542;107.244;129.44 0 0 Exp 2,1(0.34);Exp 3,1(0.34);Poly 2,1(0.34) 1.706456981931407 5.1251060962677 1.618504285812378 1.8151482343673706 0.0994072515311557 1.6914535760879517 33.63247075070076 127.40126258263258 20.08964015172006 86.22455984827994 44.41179847085833 143.41366819580833 UP 1.0 0.0 0.0 GO:0061982 4 meiosis I cell cycle process 9 9 2 2 2 2 2 2 67 7 2471 0.99858 0.023028 0.023028 22.22 360243;498709 top2a;cks2 TOP2A_10059;CKS2_8325 14.1294 14.1294 13.8391 0.41054619715692914 14.176006544256122 0.40522073005331233 9.46992 9.46992 9.31624 0.21733634026544935 9.494592730696798 0.21451712640240653 28.3955 28.3955 27.6952 0.990373757730037 28.507930461393595 0.9775269626469288 0.0 13.8391 0.0 13.8391 13.8391;14.4197 9.31624;9.6236 27.6952;29.0958 2 0 2 360243;498709 TOP2A_10059;CKS2_8325 14.1294 14.1294 0.41054619715692914 9.46992 9.46992 0.21733634026544935 28.3955 28.3955 0.990373757730037 13.8391;14.4197 9.31624;9.6236 27.6952;29.0958 0 0 Poly 2,2(1) 1.7027503912731539 3.424886465072632 1.530501127243042 1.8943853378295898 0.25730499287246167 1.712443232536316 13.560412 14.698388000000001 9.1687072 9.7711328 27.022911999999998 29.768088 UP 1.0 0.0 0.0 GO:0009719 3 response to endogenous stimulus 481 515 25 25 23 22 21 21 48 494 1984 0.98606 0.027257 0.046512 4.08 360243;24825;78968;24777;362282;24587;24516;79438;24450;360504;316033;81660;24306;29680;299691;84032;114851;58919;24770;25612;25649 top2a;tf;srebf1;slc10a1;pck1;nefh;jun;igfals;hmgcs2;hba-a2;glb1;gatm;cyp4a2;cyp11a1;cry1;col3a1;cdkn1a;ccnd1;ccl2;asns;apoa2 TOP2A_10059;TF_10003;SREBF1_32750;SLC10A1_9832;PCK1_9439;NEFH_33218;JUN_8938;IGFALS_8880;HMGCS2_8812;HBA2_32600;GLB1_8712;GATM_32792;CYP4A2_8425;CYP11A1_32785;CRY1_8386;COL3A1_8354;CDKN1A_8271;CCND1_8224;CCL2_8218;ASNS_8091;APOA2_33095 49.70722333333333 54.5478 5.51457 26.971341527676994 52.22949213789668 23.266858379966756 33.88076380952381 38.2987 1.34064 19.37668331120201 34.64005169689688 14.652896657918909 98.54440952380953 94.4701 11.4863 67.00534904822081 109.18529024135337 72.37535950167711 13.8391;51.412;11.2357;7.96762;5.51457;79.3182;57.7663;70.3663;30.5985;101.406;65.9159;37.423;59.5671;43.719;37.2548;57.8774;54.5478;28.2655;64.0097;85.6642;80.183 9.31624;36.6131;4.94421;6.07525;1.34064;39.4261;38.6865;46.0459;24.577;84.6435;47.8573;28.03;43.4174;33.4848;21.8798;39.4215;38.2987;22.3101;41.1311;53.6991;50.2978 27.6952;86.0232;24.5771;11.4863;39.6721;264.141;109.049;148.796;40.5656;115.953;114.587;55.6613;99.5908;63.9031;73.8251;106.603;94.4701;38.3337;132.851;224.488;197.161 12 9 12 360243;24825;78968;362282;24450;360504;316033;24306;29680;58919;25612;25649 TOP2A_10059;TF_10003;SREBF1_32750;PCK1_9439;HMGCS2_8812;HBA2_32600;GLB1_8712;CYP4A2_8425;CYP11A1_32785;CCND1_8224;ASNS_8091;APOA2_33095 48.1100475 47.5655 31.34412260335816 34.375099166666665 35.048950000000005 23.836873385697082 89.37915 74.96315 65.67198785958897 13.8391;51.412;11.2357;5.51457;30.5985;101.406;65.9159;59.5671;43.719;28.2655;85.6642;80.183 9.31624;36.6131;4.94421;1.34064;24.577;84.6435;47.8573;43.4174;33.4848;22.3101;53.6991;50.2978 27.6952;86.0232;24.5771;39.6721;40.5656;115.953;114.587;99.5908;63.9031;38.3337;224.488;197.161 9 24777;24587;24516;79438;81660;299691;84032;114851;24770 SLC10A1_9832;NEFH_33218;JUN_8938;IGFALS_8880;GATM_32792;CRY1_8386;COL3A1_8354;CDKN1A_8271;CCL2_8218 51.836791111111104 57.7663 21.420328716378567 33.22165 38.6865 12.510560406712417 110.76475555555557 106.603 70.71188959243541 7.96762;79.3182;57.7663;70.3663;37.423;37.2548;57.8774;54.5478;64.0097 6.07525;39.4261;38.6865;46.0459;28.03;21.8798;39.4215;38.2987;41.1311 11.4863;264.141;109.049;148.796;55.6613;73.8251;106.603;94.4701;132.851 0 Exp 2,11(0.53);Hill,2(0.1);Linear,5(0.24);Poly 2,3(0.15) 1.9567726233004437 42.02686023712158 1.5230457782745361 3.3687045574188232 0.46639043586319573 1.8943853378295898 38.17139001312534 61.24305665354134 25.59321946371853 42.168308155329086 69.88574835230467 127.20307069531437 CONFLICT 0.5714285714285714 0.42857142857142855 0.0 GO:0016042 5 lipid catabolic process 77 87 7 6 7 6 5 5 64 82 2396 0.97145 0.084268 0.084268 5.75 29692;362282;171142;29740;25649 pla2g2a;pck1;ehhadh;eci1;apoa2 PLA2G2A_32641;PCK1_9439;EHHADH_8534;ECI1_8520;APOA2_33095 44.32483400000023 32.6956 1.16694E-12 45.721742765360055 60.80431606656676 41.1479921804132 25.455908000000232 25.6436 1.16694E-12 24.743655586519658 36.03094585537569 22.646815037209322 77.82626000000023 45.0542 1.16694E-12 76.96242294963145 118.75759558465775 86.823115615474 3.5 91.707 1.16694E-12;5.51457;32.6956;103.231;80.183 1.16694E-12;1.34064;25.6436;49.9975;50.2978 1.16694E-12;39.6721;45.0542;107.244;197.161 4 1 4 362282;171142;29740;25649 PCK1_9439;EHHADH_8534;ECI1_8520;APOA2_33095 55.4060425 56.4393 44.36983738831924 31.819885 37.82055 23.37370247383942 97.282825 76.1491 73.30688861020613 5.51457;32.6956;103.231;80.183 1.34064;25.6436;49.9975;50.2978 39.6721;45.0542;107.244;197.161 1 29692 PLA2G2A_32641 1.16694E-12 1.16694E-12 1.16694E-12 1.16694E-12 1.16694E-12 1.16694E-12 1.16694E-12 1.16694E-12 1.16694E-12 0 Exp 2,1(0.2);Exp 3,1(0.2);Hill,2(0.4);Linear,1(0.2) 1.9332068164151348 9.738183617591858 1.618504285812378 2.3449018001556396 0.26735638722494554 1.9712703227996826 4.247959449743355 84.40170855025713 3.767137605906491 47.14467839409398 10.365721904041678 145.28679809595877 UP 0.8 0.2 0.0 GO:0007420 5 brain development 75 79 4 4 4 4 4 4 65 75 2403 0.93944 0.16398 0.16398 5.06 360243;24587;24450;289054 top2a;nefh;hmgcs2;aspm TOP2A_10059;NEFH_33218;HMGCS2_8812;ASPM_8092 33.519825 22.2188 10.3235 31.78797321014926 46.28374060803474 33.28699510338701 20.19511 16.946620000000003 7.4611 14.939174001142096 26.7593774495114 14.28008821258402 87.31602500000001 34.1304 16.8623 118.2808017128273 128.9868903311618 132.21650043334066 2.5 54.95835 13.8391;79.3182;30.5985;10.3235 9.31624;39.4261;24.577;7.4611 27.6952;264.141;40.5656;16.8623 3 1 3 360243;24450;289054 TOP2A_10059;HMGCS2_8812;ASPM_8092 18.2537 13.8391 10.834455506392558 13.784780000000003 9.31624 9.392251886592476 28.37436666666667 27.6952 11.866236060492527 13.8391;30.5985;10.3235 9.31624;24.577;7.4611 27.6952;40.5656;16.8623 1 24587 NEFH_33218 79.3182 79.3182 39.4261 39.4261 264.141 264.141 79.3182 39.4261 264.141 0 Exp 2,2(0.5);Poly 2,2(0.5) 2.0431506648548208 8.575477600097656 1.5452834367752075 3.3687045574188232 0.8292005346780686 1.8307448029518127 2.3676112540537275 64.67203874594627 5.554719478880747 34.83550052111925 -28.599160678570755 203.23121067857073 UP 0.75 0.25 0.0 GO:0046394 6 carboxylic acid biosynthetic process 88 95 10 10 9 8 7 7 62 88 2390 0.99644 0.013091 0.013091 7.37 25044;83792;287877;81660;24306;25612;81639 sds;scd2;pycr1;gatm;cyp4a2;asns;alox15 SDS_9798;SCD_9786;PYCR1_9631;GATM_32792;CYP4A2_8425;ASNS_8091;ALOX15_8036 70.2469 64.7394 37.423 22.88180534667957 67.12236851389324 24.51917428332372 49.282999999999994 43.4259 28.03 17.683661586428713 47.69467682975781 18.843246051394658 133.87405714285714 126.828 55.6613 60.98843758888119 122.86806759065165 60.5907259906321 3.5 74.3689 64.7394;83.9984;54.7122;37.423;59.5671;85.6642;105.624 43.4259;54.1928;38.3856;28.03;43.4174;53.6991;83.8302 126.828;206.18;94.9303;55.6613;99.5908;224.488;129.44 5 2 5 83792;287877;24306;25612;81639 SCD_9786;PYCR1_9631;CYP4A2_8425;ASNS_8091;ALOX15_8036 77.91318000000001 83.9984 20.85582582210541 54.705020000000005 53.6991 17.630117617361478 150.92582000000002 129.44 60.615265679051475 83.9984;54.7122;59.5671;85.6642;105.624 54.1928;38.3856;43.4174;53.6991;83.8302 206.18;94.9303;99.5908;224.488;129.44 2 25044;81660 SDS_9798;GATM_32792 51.0812 51.0812 19.315611677604206 35.72795 35.72795 10.886545292469966 91.24465000000001 91.24465000000001 50.322456164668644 64.7394;37.423 43.4259;28.03 126.828;55.6613 0 Exp 2,4(0.58);Linear,2(0.29);Poly 2,1(0.15) 1.8246888427935797 12.837841749191284 1.5959433317184448 2.1833407878875732 0.20185861034735472 1.8739502429962158 53.29582138125939 87.1979786187406 36.18276016851945 62.38323983148054 88.69319030389939 179.0549239818149 UP 0.7142857142857143 0.2857142857142857 0.0 GO:0022409 7 positive regulation of cell-cell adhesion 88 92 4 4 4 4 4 4 65 88 2390 0.89873 0.23711 0.31337 4.35 29142;24367;24770;81639 vnn1;fgg;ccl2;alox15 VNN1_10157;FGG_8639;CCL2_8218;ALOX15_8036 70.92112499999999 78.59604999999999 20.8684 37.65145846377227 81.2633064578555 35.95105563850574 48.354675 46.23455 17.1194 27.660052676423085 59.1001043649656 29.6165623829127 154.0541 131.1455 26.5474 125.63778389285072 144.08826776089447 101.19795435590989 20.8684;93.1824;64.0097;105.624 17.1194;51.338;41.1311;83.8302 26.5474;327.378;132.851;129.44 2 2 2 29142;81639 VNN1_10157;ALOX15_8036 63.2462 63.2462 59.93125950353453 50.4748 50.4748 47.17165905837953 77.9937 77.9937 72.75605519391495 20.8684;105.624 17.1194;83.8302 26.5474;129.44 2 24367;24770 FGG_8639;CCL2_8218 78.59604999999999 78.59604999999999 20.628213995520863 46.23455 46.23455 7.217368204892991 230.1145 230.1145 137.5513608238755 93.1824;64.0097 51.338;41.1311 327.378;132.851 0 Exp 2,3(0.75);Poly 2,1(0.25) 1.9099965104176067 7.802559733390808 1.559963583946228 2.642244338989258 0.48299917222420985 1.8001759052276611 34.02269570550319 107.81955429449678 21.247823377105384 75.46152662289464 30.929071785006272 277.17912821499374 CONFLICT 0.5 0.5 0.0 GO:0032869 7 cellular response to insulin stimulus 59 62 5 5 4 5 4 4 65 58 2420 0.9753 0.085045 0.085045 6.45 78968;362282;24450;24770 srebf1;pck1;hmgcs2;ccl2 SREBF1_32750;PCK1_9439;HMGCS2_8812;CCL2_8218 27.8396175 20.9171 5.51457 26.39434360445229 32.29071782896329 22.48960005381969 17.998237500000002 14.760605000000002 1.34064 18.495879107863235 22.616716668818075 15.470789842594266 59.41645 40.11885 24.5771 49.50288659856111 58.80560701895926 46.696109399579434 2.5 47.3041 11.2357;5.51457;30.5985;64.0097 4.94421;1.34064;24.577;41.1311 24.5771;39.6721;40.5656;132.851 3 1 3 78968;362282;24450 SREBF1_32750;PCK1_9439;HMGCS2_8812 15.782923333333335 11.2357 13.145676707329802 10.287283333333335 4.94421 12.50573592382445 34.93826666666667 39.6721 8.98414807220658 11.2357;5.51457;30.5985 4.94421;1.34064;24.577 24.5771;39.6721;40.5656 1 24770 CCL2_8218 64.0097 64.0097 41.1311 41.1311 132.851 132.851 64.0097 41.1311 132.851 0 Exp 2,2(0.5);Hill,2(0.5) 2.4359536010128062 10.1309894323349 1.559963583946228 3.3687045574188232 0.7715418886339329 2.6011606454849243 1.9731607676367524 53.70607423236325 -0.12772402570596952 36.12419902570598 10.903621133410127 107.92927886658988 UP 0.75 0.25 0.0 GO:0070374 9 positive regulation of ERK1 and ERK2 cascade 75 80 7 7 6 6 6 6 63 74 2404 0.99481 0.019696 0.019696 7.5 29692;24516;24367;24770;287562;81639 pla2g2a;jun;fgg;ccl2;ccl12;alox15 PLA2G2A_32641;JUN_8938;FGG_8639;CCL2_8218;CCL12_8217;ALOX15_8036 57.68521666666686 60.888 1.16694E-12 39.89936229933555 56.036782876759226 38.88529810824682 38.157333333333526 39.9088 1.16694E-12 29.361349322104555 38.48085523978697 31.224223901388658 172.5966666666669 131.1455 1.16694E-12 132.82356121060215 196.9281816504988 129.95952129033046 3.0 64.0097 1.16694E-12;57.7663;93.1824;64.0097;25.5289;105.624 1.16694E-12;38.6865;51.338;41.1311;13.9582;83.8302 1.16694E-12;109.049;327.378;132.851;336.862;129.44 1 5 1 81639 ALOX15_8036 105.624 105.624 83.8302 83.8302 129.44 129.44 105.624 83.8302 129.44 5 29692;24516;24367;24770;287562 PLA2G2A_32641;JUN_8938;FGG_8639;CCL2_8218;CCL12_8217 48.09746000000023 57.7663 36.06259565842387 29.022760000000233 38.6865 21.25577139632865 181.22800000000024 132.851 146.60789082617586 1.16694E-12;57.7663;93.1824;64.0097;25.5289 1.16694E-12;38.6865;51.338;41.1311;13.9582 1.16694E-12;109.049;327.378;132.851;336.862 0 Exp 2,3(0.5);Hill,1(0.17);Poly 2,2(0.34) 1.69074728674101 10.203185319900513 1.5230457782745361 1.988358974456787 0.2030702849691896 1.6257085800170898 25.759077626034845 89.61135570729888 14.663360827069024 61.65130583959804 66.31568274346768 278.87765058986605 DOWN 0.16666666666666666 0.8333333333333334 0.0 GO:0070664 7 negative regulation of leukocyte proliferation 29 30 3 3 2 2 2 2 67 28 2450 0.95416 0.19436 0.19436 6.67 29692;287562 pla2g2a;ccl12 PLA2G2A_32641;CCL12_8217 12.764450000000583 12.764450000000583 1.16694E-12 18.05165830623243 19.959866299829063 14.910209124935019 6.979100000000583 6.979100000000583 1.16694E-12 9.869937873157241 10.913271068721214 8.152316825545167 168.4310000000006 168.4310000000006 1.16694E-12 238.19740452406194 263.3768192712157 196.74497789736614 0.5 12.764450000000583 1.16694E-12;25.5289 1.16694E-12;13.9582 1.16694E-12;336.862 0 2 0 2 29692;287562 PLA2G2A_32641;CCL12_8217 12.764450000000583 12.764450000000583 18.05165830623243 6.979100000000583 6.979100000000583 9.869937873157241 168.4310000000006 168.4310000000006 238.19740452406194 1.16694E-12;25.5289 1.16694E-12;13.9582 1.16694E-12;336.862 0 Hill,1(0.5);Poly 2,1(0.5) 1.7450222119905952 3.5198241472244263 1.5314651727676392 1.988358974456787 0.3230727054564982 1.7599120736122131 -12.253871999998273 37.78277199999944 -6.699935999998273 20.658135999999438 -161.6937599999982 498.5557599999994 DOWN 0.0 1.0 0.0 GO:1903533 8 regulation of protein targeting 19 21 2 2 2 2 2 2 67 19 2459 0.98216 0.1092 0.1092 9.52 78968;24770 srebf1;ccl2 SREBF1_32750;CCL2_8218 37.622699999999995 37.622699999999995 11.2357 37.31685327033886 42.21750619506069 36.74674203326961 23.037655 23.037655 4.94421 25.587995309051674 26.18829255546254 25.19707264592989 78.71405 78.71405 24.5771 76.56120891551416 88.140994830473 75.39153886830695 0.5 37.622699999999995 11.2357;64.0097 4.94421;41.1311 24.5771;132.851 1 1 1 78968 SREBF1_32750 11.2357 11.2357 4.94421 4.94421 24.5771 24.5771 11.2357 4.94421 24.5771 1 24770 CCL2_8218 64.0097 64.0097 41.1311 41.1311 132.851 132.851 64.0097 41.1311 132.851 0 Exp 2,1(0.5);Hill,1(0.5) 2.1112722111865017 4.417383074760437 1.559963583946228 2.857419490814209 0.917439870036891 2.2086915373802185 -14.095819999999996 89.34121999999999 -12.425497200000002 58.500807200000004 -27.39437199999999 184.822472 CONFLICT 0.5 0.5 0.0 GO:0006887 5 exocytosis 32 34 2 2 2 2 2 2 67 32 2446 0.93739 0.23454 0.23454 5.88 314654;287562 myo1f;ccl12 MYO1F_32715;CCL12_8217 58.74325 58.74325 25.5289 46.9721842354068 43.98187246234939 42.07837399694633 37.5452 37.5452 13.9582 33.35705529569419 27.062483584337347 29.881741098831473 223.7845 223.7845 110.707 159.91573409924365 274.03927447289163 143.254868321665 0.5 58.74325 91.9576;25.5289 61.1322;13.9582 110.707;336.862 1 1 1 314654 MYO1F_32715 91.9576 91.9576 61.1322 61.1322 110.707 110.707 91.9576 61.1322 110.707 1 287562 CCL12_8217 25.5289 25.5289 13.9582 13.9582 336.862 336.862 25.5289 13.9582 336.862 0 Poly 2,2(1) 1.5586725663751364 3.1178284883499146 1.5314651727676392 1.5863633155822754 0.03881884905877682 1.5589142441749573 -6.3568759999999855 123.84337599999999 -8.685319999999997 83.77571999999998 2.1525999999999783 445.41640000000007 CONFLICT 0.5 0.5 0.0 GO:0048523 5 negative regulation of cellular process 938 999 39 39 33 36 31 31 38 968 1510 0.86596 0.1946 0.32093 3.1 29142;360243;78968;84386;287877;29692;360918;316351;114519;299923;314654;290350;100911740;304477;24516;85430;24367;116663;299691;84032;306575;114851;58919;24770;287562;282840;289054;25612;29657;25649;29339 vnn1;top2a;srebf1;slpi;pycr1;pla2g2a;pf4;npas2;nfil3;ndrg1;myo1f;loxl2;mrln;kntc1;jun;herpud1;fgg;dusp6;cry1;col3a1;ckap2;cdkn1a;ccnd1;ccl2;ccl12;atf5;aspm;asns;arntl;apoa2;apcs VNN1_10157;TOP2A_10059;SREBF1_32750;SLPI_9890;PYCR1_9631;PLA2G2A_32641;PF4_32963;NPAS2_9350;NFIL3_9304;NDRG1_32364;MYO1F_32715;LOXL2_9150;LOC100911740_32571;KNTC1_8976;JUN_8938;HERPUD1_8795;FGG_8639;DUSP6_8506;CRY1_8386;COL3A1_8354;CKAP2_8324;CDKN1A_8271;CCND1_8224;CCL2_8218;CCL12_8217;ATF5_8097;ASPM_8092;ASNS_8091;ARNTL_8086;APOA2_33095;APCS_8057 53.374238387096796 54.7122 1.16694E-12 32.17718396186462 56.0329826900944 29.95082442465358 33.846640967741976 38.2987 1.16694E-12 19.257089293569766 35.59762656123785 18.348440392001343 115.43531290322586 99.4319 1.16694E-12 100.3278981280505 126.5452414046601 102.89804983387685 20.8684;13.8391;11.2357;56.5193;54.7122;1.16694E-12;105.82;58.2312;33.1149;99.6641;91.9576;65.4434;91.003;7.89839;57.7663;53.893;93.1824;45.5478;37.2548;57.8774;12.1218;54.5478;28.2655;64.0097;25.5289;97.9563;10.3235;85.6642;38.2177;80.183;101.954 17.1194;9.31624;4.94421;39.3315;38.3856;1.16694E-12;53.8521;35.795;25.603;42.5546;61.1322;43.7615;54.5666;3.83458;38.6865;37.9512;51.338;33.3115;21.8798;39.4215;8.47044;38.2987;22.3101;41.1311;13.9582;75.2121;7.4611;53.6991;27.1236;50.2978;58.4986 26.5474;27.6952;24.5771;100.108;94.9303;1.16694E-12;109.875;99.4319;46.6318;105.409;110.707;129.393;273.335;12.5679;109.049;92.6554;327.378;71.7388;73.8251;106.603;21.3803;94.4701;38.3337;132.851;336.862;114.804;16.8623;224.488;63.2034;197.161;395.621 12 19 12 29142;360243;78968;287877;314654;304477;85430;306575;58919;289054;25612;25649 VNN1_10157;TOP2A_10059;SREBF1_32750;PYCR1_9631;MYO1F_32715;KNTC1_8976;HERPUD1_8795;CKAP2_8324;CCND1_8224;ASPM_8092;ASNS_8091;APOA2_33095 39.24686583333334 24.56695 32.34197792562265 26.2434975 19.71475 20.984570453531774 73.99213333333334 33.01445 72.53013093524817 20.8684;13.8391;11.2357;54.7122;91.9576;7.89839;53.893;12.1218;28.2655;10.3235;85.6642;80.183 17.1194;9.31624;4.94421;38.3856;61.1322;3.83458;37.9512;8.47044;22.3101;7.4611;53.6991;50.2978 26.5474;27.6952;24.5771;94.9303;110.707;12.5679;92.6554;21.3803;38.3337;16.8623;224.488;197.161 19 84386;29692;360918;316351;114519;299923;290350;100911740;24516;24367;116663;299691;84032;114851;24770;287562;282840;29657;29339 SLPI_9890;PLA2G2A_32641;PF4_32963;NPAS2_9350;NFIL3_9304;NDRG1_32364;LOXL2_9150;LOC100911740_32571;JUN_8938;FGG_8639;DUSP6_8506;CRY1_8386;COL3A1_8354;CDKN1A_8271;CCL2_8218;CCL12_8217;ATF5_8097;ARNTL_8086;APCS_8057 62.296789473684264 57.8774 29.483967235203323 38.648626315789535 39.3315 16.913792504667036 141.609952631579 106.603 108.13474781437871 56.5193;1.16694E-12;105.82;58.2312;33.1149;99.6641;65.4434;91.003;57.7663;93.1824;45.5478;37.2548;57.8774;54.5478;64.0097;25.5289;97.9563;38.2177;101.954 39.3315;1.16694E-12;53.8521;35.795;25.603;42.5546;43.7615;54.5666;38.6865;51.338;33.3115;21.8798;39.4215;38.2987;41.1311;13.9582;75.2121;27.1236;58.4986 100.108;1.16694E-12;109.875;99.4319;46.6318;105.409;129.393;273.335;109.049;327.378;71.7388;73.8251;106.603;94.4701;132.851;336.862;114.804;63.2034;395.621 0 Exp 2,7(0.23);Exp 3,2(0.07);Exp 5,1(0.04);Hill,2(0.07);Linear,11(0.36);Poly 2,6(0.2);Power,2(0.07) 1.945233107372127 63.68332397937775 1.5226441621780396 4.897102355957031 0.8396982547071767 1.7373461723327637 42.047020413166905 64.70145636102671 27.06763730383475 40.62564463164919 80.11724491102581 150.7533808954259 DOWN 0.3870967741935484 0.6129032258064516 0.0 GO:0033559 7 unsaturated fatty acid metabolic process 42 53 6 6 6 5 5 5 64 48 2430 0.99733 0.013206 0.013206 9.43 83792;24306;25086;499353;81639 scd2;cyp4a2;cyp2e1;cyp2c24;alox15 SCD_9786;CYP4A2_8425;CYP2E1_8421;CYP2C24_32875;ALOX15_8036 61.8615 59.5671 10.5651 36.03222622229994 65.41197496408319 36.93801673583578 43.214938000000004 43.4174 7.63639 28.718371087001422 47.05764462722118 29.495211033086466 104.77112000000002 99.5908 17.0471 70.20528786720412 109.12352368620039 68.58752642858379 1.5 54.56 83.9984;59.5671;49.5529;10.5651;105.624 54.1928;43.4174;26.9979;7.63639;83.8302 206.18;99.5908;71.5977;17.0471;129.44 4 1 4 83792;24306;25086;81639 SCD_9786;CYP4A2_8425;CYP2E1_8421;ALOX15_8036 74.6856 71.78275000000001 25.193481233181462 52.10957500000001 48.805099999999996 23.921315490077728 126.70212500000001 114.5154 58.01077535500765 83.9984;59.5671;49.5529;105.624 54.1928;43.4174;26.9979;83.8302 206.18;99.5908;71.5977;129.44 1 499353 CYP2C24_32875 10.5651 10.5651 7.63639 7.63639 17.0471 17.0471 10.5651 7.63639 17.0471 0 Exp 2,2(0.4);Poly 2,3(0.6) 1.9826978313335815 9.97466254234314 1.6914535760879517 2.2906150817871094 0.2470171841089743 1.9150761365890503 30.277861172224462 93.44513882777555 18.042175858188898 68.3877001418111 43.23347194800422 166.3087680519958 UP 0.8 0.2 0.0 GO:1901564 4 organonitrogen compound metabolic process 832 911 36 33 30 31 25 25 44 886 1592 0.58693 0.51364 1.0 2.74 29142;360847;24825;25044;287877;29692;362282;290350;24450;85430;362376;24440;81660;24367;171142;116663;299691;84032;297594;58919;24770;287562;25612;29657;25649 vnn1;ube2t;tf;sds;pycr1;pla2g2a;pck1;loxl2;hmgcs2;herpud1;herc6;hbb;gatm;fgg;ehhadh;dusp6;cry1;col3a1;cdca3;ccnd1;ccl2;ccl12;asns;arntl;apoa2 VNN1_10157;UBE2T_10125;TF_10003;SDS_9798;PYCR1_9631;PLA2G2A_32641;PCK1_9439;LOXL2_9150;HMGCS2_8812;HERPUD1_8795;HERC6_8794;HBB_8782;GATM_32792;FGG_8639;EHHADH_8534;DUSP6_8506;CRY1_8386;COL3A1_8354;CDCA3_8260;CCND1_8224;CCL2_8218;CCL12_8217;ASNS_8091;ARNTL_8086;APOA2_33095 45.27613880000004 45.5478 1.16694E-12 26.844284712573646 45.79328822169036 23.145877482157317 30.049124120000048 33.3115 1.16694E-12 16.473974691351682 30.673842420560344 14.376944876608755 108.45421080000006 86.0232 1.16694E-12 94.56774799088035 113.88022745413171 93.86403748383385 20.8684;10.9914;51.412;64.7394;54.7122;1.16694E-12;5.51457;65.4434;30.5985;53.893;53.833;91.4283;37.423;93.1824;32.6956;45.5478;37.2548;57.8774;2.6193;28.2655;64.0097;25.5289;85.6642;38.2177;80.183 17.1194;7.86591;36.6131;43.4259;38.3856;1.16694E-12;1.34064;43.7615;24.577;37.9512;36.3389;54.7263;28.03;51.338;25.6436;33.3115;21.8798;39.4215;0.978353;22.3101;41.1311;13.9582;53.6991;27.1236;50.2978 26.5474;18.2059;86.0232;126.828;94.9303;1.16694E-12;39.6721;129.393;40.5656;92.6554;98.3689;277.036;55.6613;327.378;45.0542;71.7388;73.8251;106.603;7.96997;38.3337;132.851;336.862;224.488;63.2034;197.161 12 13 12 29142;360847;24825;287877;362282;24450;85430;171142;297594;58919;25612;25649 VNN1_10157;UBE2T_10125;TF_10003;PYCR1_9631;PCK1_9439;HMGCS2_8812;HERPUD1_8795;EHHADH_8534;CDCA3_8260;CCND1_8224;ASNS_8091;APOA2_33095 38.118139166666666 31.64705 27.420319985671036 26.39848358333333 25.110300000000002 17.638373349876773 75.96723083333335 42.8099 69.30196944803586 20.8684;10.9914;51.412;54.7122;5.51457;30.5985;53.893;32.6956;2.6193;28.2655;85.6642;80.183 17.1194;7.86591;36.6131;38.3856;1.34064;24.577;37.9512;25.6436;0.978353;22.3101;53.6991;50.2978 26.5474;18.2059;86.0232;94.9303;39.6721;40.5656;92.6554;45.0542;7.96997;38.3337;224.488;197.161 13 25044;29692;290350;362376;24440;81660;24367;116663;299691;84032;24770;287562;29657 SDS_9798;PLA2G2A_32641;LOXL2_9150;HERC6_8794;HBB_8782;GATM_32792;FGG_8639;DUSP6_8506;CRY1_8386;COL3A1_8354;CCL2_8218;CCL12_8217;ARNTL_8086 51.88352307692317 53.833 25.563271400655665 33.41894615384625 36.3389 15.230505653326782 138.4421923076924 106.603 107.02318616248104 64.7394;1.16694E-12;65.4434;53.833;91.4283;37.423;93.1824;45.5478;37.2548;57.8774;64.0097;25.5289;38.2177 43.4259;1.16694E-12;43.7615;36.3389;54.7263;28.03;51.338;33.3115;21.8798;39.4215;41.1311;13.9582;27.1236 126.828;1.16694E-12;129.393;98.3689;277.036;55.6613;327.378;71.7388;73.8251;106.603;132.851;336.862;63.2034 0 Exp 2,10(0.4);Exp 4,1(0.04);Hill,2(0.08);Linear,9(0.36);Poly 2,2(0.08);Power,1(0.04) 1.9911041247316419 51.89778971672058 1.5089621543884277 4.897102355957031 0.7277030735581564 1.9088982343673706 34.75317919267118 55.79909840732891 23.59132604099019 36.50692219900991 71.38365358757495 145.52476801242517 CONFLICT 0.48 0.52 0.0 GO:0046951 5 ketone body biosynthetic process 1 1 1 1 1 1 1 1 68 0 2478 1.0 0.027091 0.027091 100.0 24450 hmgcs2 HMGCS2_8812 30.5985 30.5985 30.5985 30.5985 24.577 24.577 24.577 24.577 40.5656 40.5656 40.5656 40.5656 0.0 30.5985 0.0 30.5985 30.5985 24.577 40.5656 1 0 1 24450 HMGCS2_8812 30.5985 30.5985 24.577 24.577 40.5656 40.5656 30.5985 24.577 40.5656 0 0 Exp 2,1(1) 3.3687045574188237 3.3687045574188232 3.3687045574188232 3.3687045574188232 0.0 3.3687045574188232 30.5985 30.5985 24.577 24.577 40.5656 40.5656 UP 1.0 0.0 0.0 GO:0032886 5 regulation of microtubule-based process 52 56 4 4 4 4 4 4 65 52 2426 0.98349 0.063086 0.063086 7.14 291441;24587;306575;282840 ska1;nefh;ckap2;atf5 SKA1_9829;NEFH_33218;CKAP2_8324;ATF5_8097 50.329225 45.72 11.9206 44.88403110285996 71.26843475991649 38.355283158425536 32.8642375 23.94827 8.34831 31.793539990822424 46.341394304602844 29.93248942150822 105.3434 68.09215 21.0483 114.69037559699593 150.458291395765 110.96564045871821 1.5 45.72 11.9206;79.3182;12.1218;97.9563 8.34831;39.4261;8.47044;75.2121 21.0483;264.141;21.3803;114.804 2 2 2 291441;306575 SKA1_9829;CKAP2_8324 12.0212 12.0212 0.1422698843745472 8.409375 8.409375 0.08635895118608913 21.2143 21.2143 0.23475945135346712 11.9206;12.1218 8.34831;8.47044 21.0483;21.3803 2 24587;282840 NEFH_33218;ATF5_8097 88.63725 88.63725 13.179126898433088 57.319100000000006 57.319100000000006 25.30452327154176 189.47250000000003 189.47250000000003 105.59720538205535 79.3182;97.9563 39.4261;75.2121 264.141;114.804 0 Exp 2,1(0.25);Poly 2,3(0.75) 2.024911878627842 8.162731051445007 1.7671042680740356 2.385996103286743 0.29460543439995807 2.0048153400421143 6.342874519197252 94.31557548080276 1.7065683089940187 64.02190669100598 -7.053168085056015 217.73996808505603 CONFLICT 0.5 0.5 0.0 GO:0051384 7 response to glucocorticoid 119 133 11 11 11 9 9 9 60 124 2354 0.9974 0.0086074 0.0086074 6.77 362282;79438;24450;316033;29680;114851;58919;24770;25649 pck1;igfals;hmgcs2;glb1;cyp11a1;cdkn1a;ccnd1;ccl2;apoa2 PCK1_9439;IGFALS_8880;HMGCS2_8812;GLB1_8712;CYP11A1_32785;CDKN1A_8271;CCND1_8224;CCL2_8218;APOA2_33095 49.23558555555556 54.5478 5.51457 24.129913715213057 54.07439871364426 22.107959471409018 33.92703777777778 38.2987 1.34064 15.669940053039266 36.92630112547666 12.791587634473073 96.7044 94.4701 38.3337 56.262478009149234 107.79896522935988 62.150756176172315 5.5 64.96279999999999 5.51457;70.3663;30.5985;65.9159;43.719;54.5478;28.2655;64.0097;80.183 1.34064;46.0459;24.577;47.8573;33.4848;38.2987;22.3101;41.1311;50.2978 39.6721;148.796;40.5656;114.587;63.9031;94.4701;38.3337;132.851;197.161 6 3 6 362282;24450;316033;29680;58919;25649 PCK1_9439;HMGCS2_8812;GLB1_8712;CYP11A1_32785;CCND1_8224;APOA2_33095 42.36607833333333 37.15875 27.13624858936137 29.97794 29.030900000000003 18.18200850251699 82.37041666666667 52.234350000000006 63.34958469639455 5.51457;30.5985;65.9159;43.719;28.2655;80.183 1.34064;24.577;47.8573;33.4848;22.3101;50.2978 39.6721;40.5656;114.587;63.9031;38.3337;197.161 3 79438;114851;24770 IGFALS_8880;CDKN1A_8271;CCL2_8218 62.9746 64.0097 7.9598875350095195 41.82523333333334 41.1311 3.9199671903388675 125.37236666666666 132.851 27.92442157150864 70.3663;54.5478;64.0097 46.0459;38.2987;41.1311 148.796;94.4701;132.851 0 Exp 2,4(0.45);Hill,1(0.12);Linear,4(0.45) 2.0063066889759944 18.602875590324402 1.527578592300415 3.3687045574188232 0.5740213272737729 1.9712703227996826 33.47070859494968 65.00046251616142 23.689343609792118 44.164731945763435 59.94624770068916 133.46255229931083 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0044793 6 negative regulation by host of viral process 5 5 2 2 2 2 2 2 67 3 2475 0.99982 0.0068619 0.0068619 40.0 287562;29339 ccl12;apcs CCL12_8217;APCS_8057 63.74145 63.74145 25.5289 54.040706462859994 59.72359531601082 53.741154085874385 36.2284 36.2284 13.9582 31.494818876761304 33.886802085613866 31.320240332645685 366.2415 366.2415 336.862 41.548887355740526 363.15239546004494 41.31857822798969 0.0 25.5289 0.0 25.5289 25.5289;101.954 13.9582;58.4986 336.862;395.621 0 2 0 2 287562;29339 CCL12_8217;APCS_8057 63.74145 63.74145 54.040706462859994 36.2284 36.2284 31.494818876761304 366.2415 366.2415 41.548887355740526 25.5289;101.954 13.9582;58.4986 336.862;395.621 0 Linear,1(0.5);Poly 2,1(0.5) 1.5772935697034145 3.1559585332870483 1.5314651727676392 1.6244933605194092 0.0657808624007719 1.5779792666435242 -11.15514799999999 138.63804799999997 -7.421192000000005 79.877992 308.65768 423.8253199999999 DOWN 0.0 1.0 0.0 GO:1901565 5 organonitrogen compound catabolic process 128 143 5 5 4 3 2 2 67 141 2337 0.2448 0.90833 0.43277 1.4 25044;29657 sds;arntl SDS_9798;ARNTL_8086 51.47855 51.47855 38.2177 18.753673918595286 48.76252763488352 18.356108805228157 35.27475 35.27475 27.1236 11.527466878937462 33.6052713691868 11.283092432818044 95.01570000000001 95.01570000000001 63.2034 44.98938611028163 88.5000604832424 44.035641768405455 64.7394;38.2177 43.4259;27.1236 126.828;63.2034 0 2 0 2 25044;29657 SDS_9798;ARNTL_8086 51.47855 51.47855 18.753673918595286 35.27475 35.27475 11.527466878937462 95.01570000000001 95.01570000000001 44.98938611028163 64.7394;38.2177 43.4259;27.1236 126.828;63.2034 0 Linear,1(0.5);Power,1(0.5) 3.0647071211956787 6.815058946609497 1.9179565906524658 4.897102355957031 2.106574172790045 3.4075294733047485 25.487283999999995 77.46981600000001 19.298496 51.251003999999995 32.66359200000001 157.36780800000003 DOWN 0.0 1.0 0.0 GO:1901607 7 alpha-amino acid biosynthetic process 18 19 3 3 2 3 2 2 67 17 2461 0.98649 0.092012 0.092012 10.53 287877;25612 pycr1;asns PYCR1_9631;ASNS_8091 70.1882 70.1882 54.7122 21.88636909128605 67.6910687578419 21.599579234764644 46.04235 46.04235 38.3856 10.828279693700189 44.80689447929736 10.68639043071754 159.70915 159.70915 94.9303 91.61112822493239 149.25675337515685 90.41069419177653 0.0 54.7122 0.5 70.1882 54.7122;85.6642 38.3856;53.6991 94.9303;224.488 2 0 2 287877;25612 PYCR1_9631;ASNS_8091 70.1882 70.1882 21.88636909128605 46.04235 46.04235 10.828279693700189 159.70915 159.70915 91.61112822493239 54.7122;85.6642 38.3856;53.6991 94.9303;224.488 0 0 Exp 2,1(0.5);Linear,1(0.5) 1.6277159373408285 3.2560644149780273 1.5959433317184448 1.6601210832595825 0.045380523316043864 1.6280322074890137 39.85524000000001 100.52115999999998 31.035119999999992 61.049580000000006 32.74260400000003 286.675696 UP 1.0 0.0 0.0 GO:2000323 8 negative regulation of glucocorticoid receptor signaling pathway 2 2 2 2 2 2 2 2 67 0 2478 1.0 7.2355E-4 7.2355E-4 100.0 299691;29657 cry1;arntl CRY1_8386;ARNTL_8086 37.73625 37.73625 37.2548 0.6808731196049915 37.68248229359556 0.6766138281880805 24.5017 24.5017 21.8798 3.707926539186002 24.208889636677092 3.684731116684326 68.51425 68.51425 63.2034 7.5106760977291565 69.10735878296404 7.4636920748477955 0.0 37.2548 0.0 37.2548 37.2548;38.2177 21.8798;27.1236 73.8251;63.2034 0 2 0 2 299691;29657 CRY1_8386;ARNTL_8086 37.73625 37.73625 0.6808731196049915 24.5017 24.5017 3.707926539186002 68.51425 68.51425 7.5106760977291565 37.2548;38.2177 21.8798;27.1236 73.8251;63.2034 0 Exp 2,1(0.5);Power,1(0.5) 3.0198700784406913 6.759349584579468 1.8622472286224365 4.897102355957031 2.145966640457055 3.379674792289734 36.792608 38.679891999999995 19.362776 29.640624 58.104984 78.923516 DOWN 0.0 1.0 0.0 GO:0055085 4 transmembrane transport 188 198 2 2 2 2 2 2 67 196 2282 0.085303 0.97573 0.16838 1.01 29503;24777 slc22a2;slc10a1 SLC22A2_9845;SLC10A1_9832 44.89476 44.89476 7.96762 52.22286220765002 26.75730836396075 45.48948266863314 26.217875 26.217875 6.07525 28.485973456795364 16.324450089206067 24.813120941353066 56.78265 56.78265 11.4863 64.05871249599855 34.53450520963425 55.79927197929059 81.8219;7.96762 46.3605;6.07525 102.079;11.4863 1 1 1 29503 SLC22A2_9845 81.8219 81.8219 46.3605 46.3605 102.079 102.079 81.8219 46.3605 102.079 1 24777 SLC10A1_9832 7.96762 7.96762 6.07525 6.07525 11.4863 11.4863 7.96762 6.07525 11.4863 0 Poly 2,2(1) 2.0250040299407064 4.124663710594177 1.6717280149459839 2.4529356956481934 0.5523972485395475 2.0623318552970886 -27.482434399999995 117.2719544 -13.261670000000002 65.69742 -31.998195999999986 145.563496 CONFLICT 0.5 0.5 0.0 GO:0042221 3 response to chemical 909 981 51 49 46 45 41 41 28 940 1538 0.99988 2.9376E-4 3.9819E-4 4.18 360243;24825;78968;84386;24777;25044;83792;287877;360918;362282;316351;114519;24587;299923;286918;58827;290350;24516;79438;24450;85430;24440;360504;316033;81660;24367;361921;116663;170568;24306;25086;29680;299691;84032;114851;58919;24770;287562;25612;25649;81639 top2a;tf;srebf1;slpi;slc10a1;sds;scd2;pycr1;pf4;pck1;npas2;nfil3;nefh;ndrg1;mx2;mest;loxl2;jun;igfals;hmgcs2;herpud1;hbb;hba-a2;glb1;gatm;fgg;ect2;dusp6;dmbt1;cyp4a2;cyp2e1;cyp11a1;cry1;col3a1;cdkn1a;ccnd1;ccl2;ccl12;asns;apoa2;alox15 TOP2A_10059;TF_10003;SREBF1_32750;SLPI_9890;SLC10A1_9832;SDS_9798;SCD_9786;PYCR1_9631;PF4_32963;PCK1_9439;NPAS2_9350;NFIL3_9304;NEFH_33218;NDRG1_32364;MX2_9268;MEST_9219;LOXL2_9150;JUN_8938;IGFALS_8880;HMGCS2_8812;HERPUD1_8795;HBB_8782;HBA2_32600;GLB1_8712;GATM_32792;FGG_8639;ECT2_8523;DUSP6_8506;DMBT1_32993;CYP4A2_8425;CYP2E1_8421;CYP11A1_32785;CRY1_8386;COL3A1_8354;CDKN1A_8271;CCND1_8224;CCL2_8218;CCL12_8217;ASNS_8091;APOA2_33095;ALOX15_8036 55.98993146341463 56.5193 5.51457 28.549442201572322 55.96786623955921 26.08729600047995 36.4169168292683 38.3856 1.34064 18.578810817449188 36.20021376608832 16.384749525565113 121.06745853658536 100.108 11.4863 85.75264728127924 125.0461833198869 85.1784003457507 13.8391;51.412;11.2357;56.5193;7.96762;64.7394;83.9984;54.7122;105.82;5.51457;58.2312;33.1149;79.3182;99.6641;31.6605;96.9172;65.4434;57.7663;70.3663;30.5985;53.893;91.4283;101.406;65.9159;37.423;93.1824;14.4142;45.5478;21.7434;59.5671;49.5529;43.719;37.2548;57.8774;54.5478;28.2655;64.0097;25.5289;85.6642;80.183;105.624 9.31624;36.6131;4.94421;39.3315;6.07525;43.4259;54.1928;38.3856;53.8521;1.34064;35.795;25.603;39.4261;42.5546;23.5989;56.7353;43.7615;38.6865;46.0459;24.577;37.9512;54.7263;84.6435;47.8573;28.03;51.338;9.59235;33.3115;12.6557;43.4174;26.9979;33.4848;21.8798;39.4215;38.2987;22.3101;41.1311;13.9582;53.6991;50.2978;83.8302 27.6952;86.0232;24.5771;100.108;11.4863;126.828;206.18;94.9303;109.875;39.6721;99.4319;46.6318;264.141;105.409;46.786;331.492;129.393;109.049;148.796;40.5656;92.6554;277.036;115.953;114.587;55.6613;327.378;30.0753;71.7388;160.485;99.5908;71.5977;63.9031;73.8251;106.603;94.4701;38.3337;132.851;336.862;224.488;197.161;129.44 19 22 19 360243;24825;78968;83792;287877;362282;24450;85430;360504;316033;361921;170568;24306;25086;29680;58919;25612;25649;81639 TOP2A_10059;TF_10003;SREBF1_32750;SCD_9786;PYCR1_9631;PCK1_9439;HMGCS2_8812;HERPUD1_8795;HBA2_32600;GLB1_8712;ECT2_8523;DMBT1_32993;CYP4A2_8425;CYP2E1_8421;CYP11A1_32785;CCND1_8224;ASNS_8091;APOA2_33095;ALOX15_8036 50.59256157894737 51.412 30.90797379109912 35.58457578947368 36.6131 23.8398929473788 97.78492105263159 92.6554 62.48397793208519 13.8391;51.412;11.2357;83.9984;54.7122;5.51457;30.5985;53.893;101.406;65.9159;14.4142;21.7434;59.5671;49.5529;43.719;28.2655;85.6642;80.183;105.624 9.31624;36.6131;4.94421;54.1928;38.3856;1.34064;24.577;37.9512;84.6435;47.8573;9.59235;12.6557;43.4174;26.9979;33.4848;22.3101;53.6991;50.2978;83.8302 27.6952;86.0232;24.5771;206.18;94.9303;39.6721;40.5656;92.6554;115.953;114.587;30.0753;160.485;99.5908;71.5977;63.9031;38.3337;224.488;197.161;129.44 22 84386;24777;25044;360918;316351;114519;24587;299923;286918;58827;290350;24516;79438;24440;81660;24367;116663;299691;84032;114851;24770;287562 SLPI_9890;SLC10A1_9832;SDS_9798;PF4_32963;NPAS2_9350;NFIL3_9304;NEFH_33218;NDRG1_32364;MX2_9268;MEST_9219;LOXL2_9150;JUN_8938;IGFALS_8880;HBB_8782;GATM_32792;FGG_8639;DUSP6_8506;CRY1_8386;COL3A1_8354;CDKN1A_8271;CCL2_8218;CCL12_8217 60.65129636363636 58.0543 26.164180603134387 37.13575681818182 39.3765 13.005911497105727 141.17510454545456 107.826 98.72274012256301 56.5193;7.96762;64.7394;105.82;58.2312;33.1149;79.3182;99.6641;31.6605;96.9172;65.4434;57.7663;70.3663;91.4283;37.423;93.1824;45.5478;37.2548;57.8774;54.5478;64.0097;25.5289 39.3315;6.07525;43.4259;53.8521;35.795;25.603;39.4261;42.5546;23.5989;56.7353;43.7615;38.6865;46.0459;54.7263;28.03;51.338;33.3115;21.8798;39.4215;38.2987;41.1311;13.9582 100.108;11.4863;126.828;109.875;99.4319;46.6318;264.141;105.409;46.786;331.492;129.393;109.049;148.796;277.036;55.6613;327.378;71.7388;73.8251;106.603;94.4701;132.851;336.862 0 Exp 2,14(0.35);Exp 3,2(0.05);Hill,2(0.05);Linear,14(0.35);Poly 2,8(0.2);Power,1(0.03) 1.9357977257518075 82.04054820537567 1.5226441621780396 4.820915699005127 0.6147308675182129 1.8398383855819702 47.2509308380705 64.72893208875874 30.72993218678387 42.10390147175272 94.8185240416501 147.31639303152068 CONFLICT 0.4634146341463415 0.5365853658536586 0.0 GO:0014013 8 regulation of gliogenesis 42 46 2 2 2 2 2 2 67 44 2434 0.87327 0.35592 0.35592 4.35 24825;282840 tf;atf5 TF_10003;ATF5_8097 74.68415 74.68415 51.412 32.911790155581016 81.62543867052023 31.413738307148623 55.912600000000005 55.912600000000005 36.6131 27.293614647019545 61.668982658959536 26.051286299667826 100.4136 100.4136 86.0232 20.351098847973812 104.70576554913293 19.42477423595139 51.412;97.9563 36.6131;75.2121 86.0232;114.804 1 1 1 24825 TF_10003 51.412 51.412 36.6131 36.6131 86.0232 86.0232 51.412 36.6131 86.0232 1 282840 ATF5_8097 97.9563 97.9563 75.2121 75.2121 114.804 114.804 97.9563 75.2121 114.804 0 Linear,1(0.5);Poly 2,1(0.5) 2.1871584120974843 4.390887022018433 2.0048909187316895 2.385996103286743 0.26948206034422917 2.1954435110092163 29.07073600000001 120.297564 18.085580000000007 93.73962 72.208416 128.618784 CONFLICT 0.5 0.5 0.0 GO:0050777 6 negative regulation of immune response 45 49 3 3 3 3 3 3 66 46 2432 0.95814 0.14545 0.14545 6.12 84032;25649;81639 col3a1;apoa2;alox15 COL3A1_8354;APOA2_33095;ALOX15_8036 81.22813333333333 80.183 57.8774 23.8904516628157 88.63917251110843 18.364746829676225 57.84983333333334 50.2978 39.4215 23.14752825947799 62.85598581722108 21.221363666675543 144.40133333333333 129.44 106.603 47.09637950345363 163.2180680317041 44.23065150995895 1.5 92.90350000000001 57.8774;80.183;105.624 39.4215;50.2978;83.8302 106.603;197.161;129.44 2 1 2 25649;81639 APOA2_33095;ALOX15_8036 92.90350000000001 92.90350000000001 17.989503620166875 67.06400000000001 67.06400000000001 23.710987429459763 163.3005 163.3005 47.8859783287342 80.183;105.624 50.2978;83.8302 197.161;129.44 1 84032 COL3A1_8354 57.8774 57.8774 39.4215 39.4215 106.603 106.603 57.8774 39.4215 106.603 0 Exp 2,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 1.743492962867153 5.252201199531555 1.589477300643921 1.9712703227996826 0.19767923692209213 1.6914535760879517 54.193542284100104 108.26272438256656 31.655939256832493 84.04372740983418 91.10676286034882 197.69590380631783 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0033693 7 neurofilament bundle assembly 2 2 1 1 1 1 1 1 68 1 2477 0.99928 0.053458 0.053458 50.0 24587 nefh NEFH_33218 79.3182 79.3182 79.3182 79.3182 39.4261 39.4261 39.4261 39.4261 264.141 264.141 264.141 264.141 0.0 79.3182 0.0 79.3182 79.3182 39.4261 264.141 0 1 0 1 24587 NEFH_33218 79.3182 79.3182 39.4261 39.4261 264.141 264.141 79.3182 39.4261 264.141 0 Exp 2,1(1) 1.7671042680740356 1.7671042680740356 1.7671042680740356 1.7671042680740356 0.0 1.7671042680740356 79.3182 79.3182 39.4261 39.4261 264.141 264.141 DOWN 0.0 1.0 0.0 GO:0032369 6 negative regulation of lipid transport 13 14 2 2 2 2 2 2 67 12 2466 0.99441 0.053364 0.053364 14.29 299691;25649 cry1;apoa2 CRY1_8386;APOA2_33095 58.718900000000005 58.718900000000005 37.2548 30.35482132413236 58.75582219036697 30.354776413667043 36.0888 36.0888 21.8798 20.09456050775932 36.11324208715596 20.094530777521317 135.49305 135.49305 73.8251 87.2116512537459 135.59913018922018 87.21152222265084 0.0 37.2548 0.5 58.718900000000005 37.2548;80.183 21.8798;50.2978 73.8251;197.161 1 1 1 25649 APOA2_33095 80.183 80.183 50.2978 50.2978 197.161 197.161 80.183 50.2978 197.161 1 299691 CRY1_8386 37.2548 37.2548 21.8798 21.8798 73.8251 73.8251 37.2548 21.8798 73.8251 0 Exp 2,1(0.5);Linear,1(0.5) 1.9159834799651494 3.833517551422119 1.8622472286224365 1.9712703227996826 0.07709096919867031 1.9167587757110596 16.64926400000001 100.788536 8.239159999999998 63.93844 14.62386800000003 256.362232 CONFLICT 0.5 0.5 0.0 GO:0016310 6 phosphorylation 244 262 9 9 8 9 8 8 61 254 2224 0.72496 0.4165 0.68722 3.05 24825;362282;299691;498709;114851;58919;24770;287562 tf;pck1;cry1;cks2;cdkn1a;ccnd1;ccl2;ccl12 TF_10003;PCK1_9439;CRY1_8386;CKS2_8325;CDKN1A_8271;CCND1_8224;CCL2_8218;CCL12_8217 35.11912125 32.76015 5.51457 20.44504160226103 37.59353443583137 16.053769399365542 23.144405 22.094949999999997 1.34064 14.538017097730842 24.722840199265868 11.92640312229922 103.891625 79.92415 29.0958 100.31542187226606 131.75056756799893 119.13771076354242 51.412;5.51457;37.2548;14.4197;54.5478;28.2655;64.0097;25.5289 36.6131;1.34064;21.8798;9.6236;38.2987;22.3101;41.1311;13.9582 86.0232;39.6721;73.8251;29.0958;94.4701;38.3337;132.851;336.862 4 4 4 24825;362282;498709;58919 TF_10003;PCK1_9439;CKS2_8325;CCND1_8224 24.9029425 21.3426 19.998702324498243 17.47186 15.966849999999999 15.401375249753944 48.2812 39.0029 25.5969236186695 51.412;5.51457;14.4197;28.2655 36.6131;1.34064;9.6236;22.3101 86.0232;39.6721;29.0958;38.3337 4 299691;114851;24770;287562 CRY1_8386;CDKN1A_8271;CCL2_8218;CCL12_8217 45.335300000000004 45.901300000000006 17.23553821633274 28.81695 30.08925 13.044135016295002 159.50205 113.66055 120.74287365059415 37.2548;54.5478;64.0097;25.5289 21.8798;38.2987;41.1311;13.9582 73.8251;94.4701;132.851;336.862 0 Exp 2,2(0.25);Hill,1(0.13);Linear,3(0.38);Poly 2,2(0.25) 1.820834331291213 14.766081094741821 1.530501127243042 2.3449018001556396 0.33065869165368045 1.7633957862854004 20.95143024257215 49.28681225742785 13.07007313468478 33.21873686531522 34.37658423780074 173.40666576219928 CONFLICT 0.5 0.5 0.0 GO:0071398 6 cellular response to fatty acid 37 38 3 3 3 3 3 3 66 35 2443 0.9818 0.081835 0.081835 7.89 78968;24450;24770 srebf1;hmgcs2;ccl2 SREBF1_32750;HMGCS2_8812;CCL2_8218 35.281299999999995 30.5985 11.2357 26.69682061369856 35.637128752949714 22.111397138074423 23.55077 24.577 4.94421 18.11525911980561 25.275743495189687 14.403097264055145 65.9979 40.5656 24.5771 58.4457934138121 61.19686125431112 51.7925341547619 0.5 20.9171 11.2357;30.5985;64.0097 4.94421;24.577;41.1311 24.5771;40.5656;132.851 2 1 2 78968;24450 SREBF1_32750;HMGCS2_8812 20.9171 20.9171 13.691567182758877 14.760605000000002 14.760605000000002 13.882478942611439 32.57135 32.57135 11.30557677100111 11.2357;30.5985 4.94421;24.577 24.5771;40.5656 1 24770 CCL2_8218 64.0097 64.0097 41.1311 41.1311 132.851 132.851 64.0097 41.1311 132.851 0 Exp 2,2(0.67);Hill,1(0.34) 2.467083198885109 7.78608763217926 1.559963583946228 3.3687045574188232 0.932411582825068 2.857419490814209 5.071003527061013 65.49159647293898 3.0514245306512073 44.050115469348796 -0.13974133851270665 132.13554133851272 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0000165 8 MAPK cascade 43 45 2 2 2 2 2 2 67 43 2435 0.8793 0.34595 0.34595 4.44 24825;24770 tf;ccl2 TF_10003;CCL2_8218 57.71084999999999 57.71084999999999 51.412 8.90791909735376 56.421434150836404 8.71927956776536 38.8721 38.8721 36.6131 3.1947084374008137 38.4096679047349 3.127055342416918 109.4371 109.4371 86.0232 33.112254928047435 104.64412132123618 32.41104961567628 51.412;64.0097 36.6131;41.1311 86.0232;132.851 1 1 1 24825 TF_10003 51.412 51.412 36.6131 36.6131 86.0232 86.0232 51.412 36.6131 86.0232 1 24770 CCL2_8218 64.0097 64.0097 41.1311 41.1311 132.851 132.851 64.0097 41.1311 132.851 0 Exp 2,1(0.5);Linear,1(0.5) 1.7684899838579613 3.5648545026779175 1.559963583946228 2.0048909187316895 0.31461113556205705 1.7824272513389587 45.365103999999995 70.05659599999998 34.44446000000001 43.29974 63.545856000000015 155.328344 CONFLICT 0.5 0.5 0.0 GO:2001234 7 negative regulation of apoptotic signaling pathway 88 93 5 5 5 4 4 4 65 89 2389 0.89513 0.24305 0.31717 4.3 29142;360918;85430;24367 vnn1;pf4;herpud1;fgg VNN1_10157;PF4_32963;HERPUD1_8795;FGG_8639 68.44095 73.5377 20.8684 38.661449747390485 65.31346779318021 36.680370974770675 40.065175 44.6446 17.1194 16.814015632674817 39.24060748760498 15.933465652254144 139.11395 101.2652 26.5474 130.54742914168526 132.57535462916115 124.76511499512524 20.8684;105.82;53.893;93.1824 17.1194;53.8521;37.9512;51.338 26.5474;109.875;92.6554;327.378 2 2 2 29142;85430 VNN1_10157;HERPUD1_8795 37.380700000000004 37.380700000000004 23.35191860597325 27.5353 27.5353 14.730307044321922 59.6014 59.6014 46.7454150906803 20.8684;53.893 17.1194;37.9512 26.5474;92.6554 2 360918;24367 PF4_32963;FGG_8639 99.5012 99.5012 8.936132657923038 52.59505 52.59505 1.7777371585809807 218.6265 218.6265 153.7978462284176 105.82;93.1824 53.8521;51.338 109.875;327.378 0 Exp 2,2(0.5);Exp 3,1(0.25);Linear,1(0.25) 1.9402145526443375 7.9180673360824585 1.5270863771438599 2.642244338989258 0.47201628493336406 1.8743683099746704 30.552729247557323 106.32917075244268 23.58743967997867 56.54291032002132 11.177469441148446 267.05043055885153 CONFLICT 0.5 0.5 0.0 GO:0007127 7 meiosis I 8 8 1 1 1 1 1 1 68 7 2471 0.98177 0.1975 0.1975 12.5 498709 cks2 CKS2_8325 14.4197 14.4197 14.4197 14.4197 9.6236 9.6236 9.6236 9.6236 29.0958 29.0958 29.0958 29.0958 0.0 14.4197 0.0 14.4197 14.4197 9.6236 29.0958 1 0 1 498709 CKS2_8325 14.4197 14.4197 9.6236 9.6236 29.0958 29.0958 14.4197 9.6236 29.0958 0 0 Poly 2,1(1) 1.530501127243042 1.530501127243042 1.530501127243042 1.530501127243042 0.0 1.530501127243042 14.4197 14.4197 9.6236 9.6236 29.0958 29.0958 UP 1.0 0.0 0.0 GO:0009725 4 response to hormone 388 419 24 24 22 21 20 20 49 399 2079 0.99751 0.0058339 0.0077097 4.77 360243;24825;78968;24777;362282;24587;24516;79438;24450;360504;316033;81660;24306;29680;299691;114851;58919;24770;25612;25649 top2a;tf;srebf1;slc10a1;pck1;nefh;jun;igfals;hmgcs2;hba-a2;glb1;gatm;cyp4a2;cyp11a1;cry1;cdkn1a;ccnd1;ccl2;asns;apoa2 TOP2A_10059;TF_10003;SREBF1_32750;SLC10A1_9832;PCK1_9439;NEFH_33218;JUN_8938;IGFALS_8880;HMGCS2_8812;HBA2_32600;GLB1_8712;GATM_32792;CYP4A2_8425;CYP11A1_32785;CRY1_8386;CDKN1A_8271;CCND1_8224;CCL2_8218;ASNS_8091;APOA2_33095 49.298714499999996 52.9799 5.51457 27.605277813404022 52.15855185459544 23.432733724845132 33.603727000000006 37.4559 1.34064 19.83734168502902 34.57999453847752 14.75272871724862 98.14148 90.24665 11.4863 68.71993049479974 109.21772497749996 72.91906928919364 13.8391;51.412;11.2357;7.96762;5.51457;79.3182;57.7663;70.3663;30.5985;101.406;65.9159;37.423;59.5671;43.719;37.2548;54.5478;28.2655;64.0097;85.6642;80.183 9.31624;36.6131;4.94421;6.07525;1.34064;39.4261;38.6865;46.0459;24.577;84.6435;47.8573;28.03;43.4174;33.4848;21.8798;38.2987;22.3101;41.1311;53.6991;50.2978 27.6952;86.0232;24.5771;11.4863;39.6721;264.141;109.049;148.796;40.5656;115.953;114.587;55.6613;99.5908;63.9031;73.8251;94.4701;38.3337;132.851;224.488;197.161 12 8 12 360243;24825;78968;362282;24450;360504;316033;24306;29680;58919;25612;25649 TOP2A_10059;TF_10003;SREBF1_32750;PCK1_9439;HMGCS2_8812;HBA2_32600;GLB1_8712;CYP4A2_8425;CYP11A1_32785;CCND1_8224;ASNS_8091;APOA2_33095 48.1100475 47.5655 31.34412260335816 34.375099166666665 35.048950000000005 23.836873385697082 89.37915 74.96315 65.67198785958897 13.8391;51.412;11.2357;5.51457;30.5985;101.406;65.9159;59.5671;43.719;28.2655;85.6642;80.183 9.31624;36.6131;4.94421;1.34064;24.577;84.6435;47.8573;43.4174;33.4848;22.3101;53.6991;50.2978 27.6952;86.0232;24.5771;39.6721;40.5656;115.953;114.587;99.5908;63.9031;38.3337;224.488;197.161 8 24777;24587;24516;79438;81660;299691;114851;24770 SLC10A1_9832;NEFH_33218;JUN_8938;IGFALS_8880;GATM_32792;CRY1_8386;CDKN1A_8271;CCL2_8218 51.081714999999996 56.15705 22.770889258388678 32.44666875 38.492599999999996 13.141374498640804 111.284975 101.75955 75.57577597767595 7.96762;79.3182;57.7663;70.3663;37.423;37.2548;54.5478;64.0097 6.07525;39.4261;38.6865;46.0459;28.03;21.8798;38.2987;41.1311 11.4863;264.141;109.049;148.796;55.6613;73.8251;94.4701;132.851 0 Exp 2,10(0.5);Hill,2(0.1);Linear,5(0.25);Poly 2,3(0.15) 1.9772184999550249 40.43738293647766 1.5230457782745361 3.3687045574188232 0.46861167015906907 1.90473073720932 37.20016806520653 61.39726093479347 24.909628677879432 42.297825322120566 68.02364254489514 128.25931745510485 UP 0.6 0.4 0.0 GO:0050877 4 nervous system process 155 163 4 4 4 3 3 3 66 160 2318 0.34525 0.82985 0.62305 1.84 24516;81660;24770 jun;gatm;ccl2 JUN_8938;GATM_32792;CCL2_8218 53.06633333333334 57.7663 37.423 13.902532834823063 47.6974072446755 13.93625135210874 35.9492 38.6865 28.03 6.966298426711312 33.28257610822293 7.078808769566142 99.1871 109.049 55.6613 39.5285371627891 83.78783976186484 38.70258397546278 57.7663;37.423;64.0097 38.6865;28.03;41.1311 109.049;55.6613;132.851 0 3 0 3 24516;81660;24770 JUN_8938;GATM_32792;CCL2_8218 53.06633333333334 57.7663 13.902532834823063 35.9492 38.6865 6.966298426711312 99.1871 109.049 39.5285371627891 57.7663;37.423;64.0097 38.6865;28.03;41.1311 109.049;55.6613;132.851 0 Exp 2,3(1) 1.731076717010596 5.266350150108337 1.5230457782745361 2.1833407878875732 0.3710237104932835 1.559963583946228 37.334136427112036 68.79853023955464 28.066091227042634 43.83230877295736 54.456349319647494 143.9178506803525 DOWN 0.0 1.0 0.0 GO:0009966 5 regulation of signal transduction 594 626 22 22 18 18 16 16 53 610 1868 0.45728 0.65318 0.8876 2.56 29142;24825;29692;360918;338475;24516;85430;24367;116663;299691;84032;24770;287562;289054;29657;81639 vnn1;tf;pla2g2a;pf4;nrep;jun;herpud1;fgg;dusp6;cry1;col3a1;ccl2;ccl12;aspm;arntl;alox15 VNN1_10157;TF_10003;PLA2G2A_32641;PF4_32963;NREP_9364;JUN_8938;HERPUD1_8795;FGG_8639;DUSP6_8506;CRY1_8386;COL3A1_8354;CCL2_8218;CCL12_8217;ASPM_8092;ARNTL_8086;ALOX15_8036 50.26168125000008 48.4799 1.16694E-12 31.010474761779278 48.1691556470868 28.216441891208774 33.23191250000008 34.9623 1.16694E-12 20.116612875328382 32.7518850043982 20.954718143459086 108.52988125000006 89.33930000000001 1.16694E-12 95.34486293467667 121.3716265327209 103.25794549873287 20.8684;51.412;1.16694E-12;105.82;36.861;57.7663;53.893;93.1824;45.5478;37.2548;57.8774;64.0097;25.5289;10.3235;38.2177;105.624 17.1194;36.6131;1.16694E-12;53.8521;28.0333;38.6865;37.9512;51.338;33.3115;21.8798;39.4215;41.1311;13.9582;7.4611;27.1236;83.8302 26.5474;86.0232;1.16694E-12;109.875;53.5645;109.049;92.6554;327.378;71.7388;73.8251;106.603;132.851;336.862;16.8623;63.2034;129.44 5 11 5 29142;24825;85430;289054;81639 VNN1_10157;TF_10003;HERPUD1_8795;ASPM_8092;ALOX15_8036 48.42417999999999 51.412 37.153860150891454 36.595000000000006 36.6131 29.415501226649187 70.30566 86.0232 47.47209747649666 20.8684;51.412;53.893;10.3235;105.624 17.1194;36.6131;37.9512;7.4611;83.8302 26.5474;86.0232;92.6554;16.8623;129.44 11 29692;360918;338475;24516;24367;116663;299691;84032;24770;287562;29657 PLA2G2A_32641;PF4_32963;NREP_9364;JUN_8938;FGG_8639;DUSP6_8506;CRY1_8386;COL3A1_8354;CCL2_8218;CCL12_8217;ARNTL_8086 51.0969090909092 45.5478 29.79689608430545 31.70323636363647 33.3115 15.895998579156267 125.90452727272738 106.603 108.03662626433756 1.16694E-12;105.82;36.861;57.7663;93.1824;45.5478;37.2548;57.8774;64.0097;25.5289;38.2177 1.16694E-12;53.8521;28.0333;38.6865;51.338;33.3115;21.8798;39.4215;41.1311;13.9582;27.1236 1.16694E-12;109.875;53.5645;109.049;327.378;71.7388;73.8251;106.603;132.851;336.862;63.2034 0 Exp 2,6(0.38);Exp 3,1(0.07);Hill,1(0.07);Linear,4(0.25);Poly 2,3(0.19);Power,1(0.07) 1.8576598755935239 31.32637858390808 1.5230457782745361 4.897102355957031 0.8357218465205846 1.6694138050079346 35.06654861672822 65.45681388327193 23.374772191089157 43.089052808910985 61.81089841200853 155.24886408799165 DOWN 0.3125 0.6875 0.0 GO:0097305 5 response to alcohol 168 183 9 9 9 9 9 9 60 174 2304 0.97651 0.055646 0.090884 4.92 78968;24777;24450;316033;25086;29680;114851;58919;24770 srebf1;slc10a1;hmgcs2;glb1;cyp2e1;cyp11a1;cdkn1a;ccnd1;ccl2 SREBF1_32750;SLC10A1_9832;HMGCS2_8812;GLB1_8712;CYP2E1_8421;CYP11A1_32785;CDKN1A_8271;CCND1_8224;CCL2_8218 39.53473555555555 43.719 7.96762 21.33782934009171 38.74297847411145 19.464423045307495 27.297373333333336 26.9979 4.94421 14.8146947979118 27.391128424747702 13.072677799097853 65.81906666666666 63.9031 11.4863 41.496489246410974 63.22682758062747 38.66222020716822 11.2357;7.96762;30.5985;65.9159;49.5529;43.719;54.5478;28.2655;64.0097 4.94421;6.07525;24.577;47.8573;26.9979;33.4848;38.2987;22.3101;41.1311 24.5771;11.4863;40.5656;114.587;71.5977;63.9031;94.4701;38.3337;132.851 6 3 6 78968;24450;316033;25086;29680;58919 SREBF1_32750;HMGCS2_8812;GLB1_8712;CYP2E1_8421;CYP11A1_32785;CCND1_8224 38.21458333333333 37.15875 19.031910588106136 26.695218333333333 25.78745 14.077259755279673 58.92736666666667 52.234350000000006 32.32486489918661 11.2357;30.5985;65.9159;49.5529;43.719;28.2655 4.94421;24.577;47.8573;26.9979;33.4848;22.3101 24.5771;40.5656;114.587;71.5977;63.9031;38.3337 3 24777;114851;24770 SLC10A1_9832;CDKN1A_8271;CCL2_8218 42.17504 54.5478 29.99987625299144 28.501683333333332 38.2987 19.473425648324778 79.60246666666667 94.4701 62.03331759807252 7.96762;54.5478;64.0097 6.07525;38.2987;41.1311 11.4863;94.4701;132.851 0 Exp 2,4(0.45);Hill,1(0.12);Linear,2(0.23);Poly 2,2(0.23) 2.1885946547886257 20.27304756641388 1.559963583946228 3.3687045574188232 0.5853523964139214 2.2035675048828125 25.594020386695647 53.47545072441545 17.61843939869762 36.97630726796905 38.70802702567818 92.93010630765517 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0030336 7 negative regulation of cell migration 73 78 3 3 2 3 2 2 67 76 2402 0.64535 0.63201 1.0 2.56 84032;24770 col3a1;ccl2 COL3A1_8354;CCL2_8218 60.94355 60.94355 57.8774 4.336190914270134 62.09852920245399 4.016789480268671 40.276300000000006 40.276300000000006 39.4215 1.208869753116359 40.59829214723926 1.1198250730505788 119.727 119.727 106.603 18.560138792584475 124.67064171779141 17.193009193629447 57.8774;64.0097 39.4215;41.1311 106.603;132.851 0 2 0 2 84032;24770 COL3A1_8354;CCL2_8218 60.94355 60.94355 4.336190914270134 40.276300000000006 40.276300000000006 1.208869753116359 119.727 119.727 18.560138792584475 57.8774;64.0097 39.4215;41.1311 106.603;132.851 0 Exp 2,2(1) 1.574651296799919 3.149440884590149 1.559963583946228 1.589477300643921 0.020869349214957266 1.5747204422950745 54.93389600000001 66.953204 38.600892 41.95170800000001 94.00396 145.45004 DOWN 0.0 1.0 0.0 GO:0051100 5 negative regulation of binding 52 53 4 4 4 4 4 4 65 49 2429 0.98679 0.053398 0.053398 7.55 84386;100911740;24516;114851 slpi;mrln;jun;cdkn1a SLPI_9890;LOC100911740_32571;JUN_8938;CDKN1A_8271 64.9591 57.1428 54.5478 17.413084072807592 58.19682865837978 9.780825900050907 42.720825 39.009 38.2987 7.908663541279698 39.738323669095585 4.401049498168591 144.240525 104.5785 94.4701 86.27205394353282 110.70920879554225 48.364579768053865 1.5 57.1428 56.5193;91.003;57.7663;54.5478 39.3315;54.5666;38.6865;38.2987 100.108;273.335;109.049;94.4701 0 4 0 4 84386;100911740;24516;114851 SLPI_9890;LOC100911740_32571;JUN_8938;CDKN1A_8271 64.9591 57.1428 17.413084072807592 42.720825 39.009 7.908663541279698 144.240525 104.5785 86.27205394353282 56.5193;91.003;57.7663;54.5478 39.3315;54.5666;38.6865;38.2987 100.108;273.335;109.049;94.4701 0 Exp 2,1(0.25);Linear,3(0.75) 1.6428782447073573 6.585920333862305 1.5230457782745361 1.8159936666488647 0.12703227098723252 1.623440444469452 47.89427760864854 82.02392239135148 34.970334729545904 50.471315270454106 59.69391213533787 228.7871378646621 DOWN 0.0 1.0 0.0 GO:0050789 3 regulation of biological process 1644 1779 62 61 55 54 49 49 20 1730 748 0.63006 0.47428 0.89479 2.75 29142;360243;24825;78968;84386;24777;291441;287877;29692;360918;362282;338475;316351;114519;24587;299923;314654;286918;58827;366960;290350;100911740;304477;303575;24516;85430;24440;360504;81660;24367;361921;116663;170568;24309;299691;84032;498709;306575;114851;58919;24770;287562;282840;289054;25612;29657;25649;29339;81639 vnn1;top2a;tf;srebf1;slpi;slc10a1;ska1;pycr1;pla2g2a;pf4;pck1;nrep;npas2;nfil3;nefh;ndrg1;myo1f;mx2;mest;maff;loxl2;mrln;kntc1;kif18b;jun;herpud1;hbb;hba-a2;gatm;fgg;ect2;dusp6;dmbt1;dbp;cry1;col3a1;cks2;ckap2;cdkn1a;ccnd1;ccl2;ccl12;atf5;aspm;asns;arntl;apoa2;apcs;alox15 VNN1_10157;TOP2A_10059;TF_10003;SREBF1_32750;SLPI_9890;SLC10A1_9832;SKA1_9829;PYCR1_9631;PLA2G2A_32641;PF4_32963;PCK1_9439;NREP_9364;NPAS2_9350;NFIL3_9304;NEFH_33218;NDRG1_32364;MYO1F_32715;MX2_9268;MEST_9219;MAFF_9172;LOXL2_9150;LOC100911740_32571;KNTC1_8976;KIF18B_32882;JUN_8938;HERPUD1_8795;HBB_8782;HBA2_32600;GATM_32792;FGG_8639;ECT2_8523;DUSP6_8506;DMBT1_32993;DBP_8439;CRY1_8386;COL3A1_8354;CKS2_8325;CKAP2_8324;CDKN1A_8271;CCND1_8224;CCL2_8218;CCL12_8217;ATF5_8097;ASPM_8092;ASNS_8091;ARNTL_8086;APOA2_33095;APCS_8057;ALOX15_8036 50.51169755102043 51.412 1.16694E-12 33.32978763005492 53.16345773428005 31.004360579451255 32.94600530612248 36.6131 1.16694E-12 21.69548545891639 34.477649904563016 20.025270334264388 110.3361428571429 94.4701 1.16694E-12 98.42460242522779 119.87562696919709 100.22324343039199 20.8684;13.8391;51.412;11.2357;56.5193;7.96762;11.9206;54.7122;1.16694E-12;105.82;5.51457;36.861;58.2312;33.1149;79.3182;99.6641;91.9576;31.6605;96.9172;58.0695;65.4434;91.003;7.89839;3.6768;57.7663;53.893;91.4283;101.406;37.423;93.1824;14.4142;45.5478;21.7434;50.6952;37.2548;57.8774;14.4197;12.1218;54.5478;28.2655;64.0097;25.5289;97.9563;10.3235;85.6642;38.2177;80.183;101.954;105.624 17.1194;9.31624;36.6131;4.94421;39.3315;6.07525;8.34831;38.3856;1.16694E-12;53.8521;1.34064;28.0333;35.795;25.603;39.4261;42.5546;61.1322;23.5989;56.7353;40.1293;43.7615;54.5666;3.83458;1.12034;38.6865;37.9512;54.7263;84.6435;28.03;51.338;9.59235;33.3115;12.6557;40.5862;21.8798;39.4215;9.6236;8.47044;38.2987;22.3101;41.1311;13.9582;75.2121;7.4611;53.6991;27.1236;50.2978;58.4986;83.8302 26.5474;27.6952;86.0232;24.5771;100.108;11.4863;21.0483;94.9303;1.16694E-12;109.875;39.6721;53.5645;99.4319;46.6318;264.141;105.409;110.707;46.786;331.492;104.733;129.393;273.335;12.5679;11.7489;109.049;92.6554;277.036;115.953;55.6613;327.378;30.0753;71.7388;160.485;59.5346;73.8251;106.603;29.0958;21.3803;94.4701;38.3337;132.851;336.862;114.804;16.8623;224.488;63.2034;197.161;395.621;129.44 22 27 22 29142;360243;24825;78968;291441;287877;362282;314654;366960;304477;303575;85430;360504;361921;170568;498709;306575;58919;289054;25612;25649;81639 VNN1_10157;TOP2A_10059;TF_10003;SREBF1_32750;SKA1_9829;PYCR1_9631;PCK1_9439;MYO1F_32715;MAFF_9172;KNTC1_8976;KIF18B_32882;HERPUD1_8795;HBA2_32600;ECT2_8523;DMBT1_32993;CKS2_8325;CKAP2_8324;CCND1_8224;ASPM_8092;ASNS_8091;APOA2_33095;ALOX15_8036 39.0528709090909 21.3059 34.48009628586324 27.400864090909092 14.88755 25.958952053302784 73.46273636363637 39.0029 62.89299303605212 20.8684;13.8391;51.412;11.2357;11.9206;54.7122;5.51457;91.9576;58.0695;7.89839;3.6768;53.893;101.406;14.4142;21.7434;14.4197;12.1218;28.2655;10.3235;85.6642;80.183;105.624 17.1194;9.31624;36.6131;4.94421;8.34831;38.3856;1.34064;61.1322;40.1293;3.83458;1.12034;37.9512;84.6435;9.59235;12.6557;9.6236;8.47044;22.3101;7.4611;53.6991;50.2978;83.8302 26.5474;27.6952;86.0232;24.5771;21.0483;94.9303;39.6721;110.707;104.733;12.5679;11.7489;92.6554;115.953;30.0753;160.485;29.0958;21.3803;38.3337;16.8623;224.488;197.161;129.44 27 84386;24777;29692;360918;338475;316351;114519;24587;299923;286918;58827;290350;100911740;24516;24440;81660;24367;116663;24309;299691;84032;114851;24770;287562;282840;29657;29339 SLPI_9890;SLC10A1_9832;PLA2G2A_32641;PF4_32963;NREP_9364;NPAS2_9350;NFIL3_9304;NEFH_33218;NDRG1_32364;MX2_9268;MEST_9219;LOXL2_9150;LOC100911740_32571;JUN_8938;HBB_8782;GATM_32792;FGG_8639;DUSP6_8506;DBP_8439;CRY1_8386;COL3A1_8354;CDKN1A_8271;CCL2_8218;CCL12_8217;ATF5_8097;ARNTL_8086;APCS_8057 59.848519259259305 57.7663 29.815527577630927 37.46426851851856 39.3315 16.657683939616 140.38114074074082 105.409 112.25726013638435 56.5193;7.96762;1.16694E-12;105.82;36.861;58.2312;33.1149;79.3182;99.6641;31.6605;96.9172;65.4434;91.003;57.7663;91.4283;37.423;93.1824;45.5478;50.6952;37.2548;57.8774;54.5478;64.0097;25.5289;97.9563;38.2177;101.954 39.3315;6.07525;1.16694E-12;53.8521;28.0333;35.795;25.603;39.4261;42.5546;23.5989;56.7353;43.7615;54.5666;38.6865;54.7263;28.03;51.338;33.3115;40.5862;21.8798;39.4215;38.2987;41.1311;13.9582;75.2121;27.1236;58.4986 100.108;11.4863;1.16694E-12;109.875;53.5645;99.4319;46.6318;264.141;105.409;46.786;331.492;129.393;273.335;109.049;277.036;55.6613;327.378;71.7388;59.5346;73.8251;106.603;94.4701;132.851;336.862;114.804;63.2034;395.621 0 Exp 2,10(0.21);Exp 3,2(0.05);Exp 4,1(0.03);Exp 5,1(0.03);Hill,3(0.07);Linear,16(0.33);Poly 2,14(0.29);Power,2(0.05) 1.9731734880260292 102.13165295124054 1.5226441621780396 5.737884044647217 0.8725858055559035 1.8159936666488647 41.17935701460505 59.84403808743581 26.871269377625886 39.020741234619074 82.77725417807909 137.89503153620666 CONFLICT 0.4489795918367347 0.5510204081632653 0.0 GO:0051412 6 response to corticosterone 23 27 3 3 3 3 3 3 66 24 2454 0.99459 0.034972 0.034972 11.11 29680;114851;58919 cyp11a1;cdkn1a;ccnd1 CYP11A1_32785;CDKN1A_8271;CCND1_8224 42.17743333333333 43.719 28.2655 13.208790412575036 43.55528597063621 14.952162406834582 31.36453333333333 33.4848 22.3101 8.202467954422827 31.813189517249707 9.125420249979806 65.56896666666667 63.9031 38.3337 28.10525191229092 70.14543413086822 32.05316746662194 0.5 35.99225 1.5 49.1334 43.719;54.5478;28.2655 33.4848;38.2987;22.3101 63.9031;94.4701;38.3337 2 1 2 29680;58919 CYP11A1_32785;CCND1_8224 35.99225 35.99225 10.927274643066331 27.89745 27.89745 7.901706147725311 51.1184 51.1184 18.08029613087131 43.719;28.2655 33.4848;22.3101 63.9031;38.3337 1 114851 CDKN1A_8271 54.5478 54.5478 38.2987 38.2987 94.4701 94.4701 54.5478 38.2987 94.4701 0 Exp 2,1(0.34);Linear,2(0.67) 1.8772694089086515 5.684878826141357 1.6645443439483643 2.2675669193267822 0.3256884861808045 1.752767562866211 27.23027988060906 57.124586786057606 22.082567053582956 40.64649961308371 33.764880142547966 97.37305319078537 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0042493 4 response to drug 436 472 26 25 24 23 22 22 47 450 2028 0.99789 0.0048634 0.0068596 4.66 360243;78968;24777;25044;362282;316351;24587;24516;79438;24450;24440;360504;361921;116663;24306;25086;29680;114851;58919;24770;25612;25649 top2a;srebf1;slc10a1;sds;pck1;npas2;nefh;jun;igfals;hmgcs2;hbb;hba-a2;ect2;dusp6;cyp4a2;cyp2e1;cyp11a1;cdkn1a;ccnd1;ccl2;asns;apoa2 TOP2A_10059;SREBF1_32750;SLC10A1_9832;SDS_9798;PCK1_9439;NPAS2_9350;NEFH_33218;JUN_8938;IGFALS_8880;HMGCS2_8812;HBB_8782;HBA2_32600;ECT2_8523;DUSP6_8506;CYP4A2_8425;CYP2E1_8421;CYP11A1_32785;CDKN1A_8271;CCND1_8224;CCL2_8218;ASNS_8091;APOA2_33095 50.81283590909091 56.15705 5.51457 28.60737797025773 54.571507500748936 24.310313300781576 33.70651318181819 37.04685 1.34064 19.83697942122774 35.69548783308691 15.105437931618015 104.97457727272727 96.951 11.4863 77.07395673833535 116.00840601957886 76.43651936151105 13.8391;11.2357;7.96762;64.7394;5.51457;58.2312;79.3182;57.7663;70.3663;30.5985;91.4283;101.406;14.4142;45.5478;59.5671;49.5529;43.719;54.5478;28.2655;64.0097;85.6642;80.183 9.31624;4.94421;6.07525;43.4259;1.34064;35.795;39.4261;38.6865;46.0459;24.577;54.7263;84.6435;9.59235;33.3115;43.4174;26.9979;33.4848;38.2987;22.3101;41.1311;53.6991;50.2978 27.6952;24.5771;11.4863;126.828;39.6721;99.4319;264.141;109.049;148.796;40.5656;277.036;115.953;30.0753;71.7388;99.5908;71.5977;63.9031;94.4701;38.3337;132.851;224.488;197.161 12 10 12 360243;78968;362282;24450;360504;361921;24306;25086;29680;58919;25612;25649 TOP2A_10059;SREBF1_32750;PCK1_9439;HMGCS2_8812;HBA2_32600;ECT2_8523;CYP4A2_8425;CYP2E1_8421;CYP11A1_32785;CCND1_8224;ASNS_8091;APOA2_33095 43.66331416666666 37.15875 32.16329596404812 30.385086666666666 25.78745 24.385071440280964 81.13438333333335 52.234350000000006 67.29286348895648 13.8391;11.2357;5.51457;30.5985;101.406;14.4142;59.5671;49.5529;43.719;28.2655;85.6642;80.183 9.31624;4.94421;1.34064;24.577;84.6435;9.59235;43.4174;26.9979;33.4848;22.3101;53.6991;50.2978 27.6952;24.5771;39.6721;40.5656;115.953;30.0753;99.5908;71.5977;63.9031;38.3337;224.488;197.161 10 24777;25044;316351;24587;24516;79438;24440;116663;114851;24770 SLC10A1_9832;SDS_9798;NPAS2_9350;NEFH_33218;JUN_8938;IGFALS_8880;HBB_8782;DUSP6_8506;CDKN1A_8271;CCL2_8218 59.392261999999995 61.12045 22.254378911870536 37.69222499999999 39.0563 12.611416904166433 133.58281000000002 117.9385 81.60344406456616 7.96762;64.7394;58.2312;79.3182;57.7663;70.3663;91.4283;45.5478;54.5478;64.0097 6.07525;43.4259;35.795;39.4261;38.6865;46.0459;54.7263;33.3115;38.2987;41.1311 11.4863;126.828;99.4319;264.141;109.049;148.796;277.036;71.7388;94.4701;132.851 0 Exp 2,7(0.32);Hill,2(0.1);Linear,7(0.32);Poly 2,5(0.23);Power,1(0.05) 2.0114831986442145 46.28649652004242 1.5230457782745361 4.820915699005127 0.7613114548010869 1.8370786905288696 38.85857349551418 62.76709832266762 25.417167064861154 41.99585929877521 72.7674206063374 137.18173393911715 CONFLICT 0.5454545454545454 0.45454545454545453 0.0 GO:1901617 5 organic hydroxy compound biosynthetic process 60 64 5 5 4 5 4 4 65 60 2418 0.97208 0.093104 0.093104 6.25 362282;24450;29680;81639 pck1;hmgcs2;cyp11a1;alox15 PCK1_9439;HMGCS2_8812;CYP11A1_32785;ALOX15_8036 46.3640175 37.15875 5.51457 42.567477987205486 60.88068719903393 44.33805221494497 35.80816 29.030900000000003 1.34064 34.76426909604746 48.03145495912807 35.60564806498739 68.3952 52.234350000000006 39.6721 42.21433279199533 79.80369209189992 48.66509872870593 2.5 74.6715 5.51457;30.5985;43.719;105.624 1.34064;24.577;33.4848;83.8302 39.6721;40.5656;63.9031;129.44 4 0 4 362282;24450;29680;81639 PCK1_9439;HMGCS2_8812;CYP11A1_32785;ALOX15_8036 46.3640175 37.15875 42.567477987205486 35.80816 29.030900000000003 34.76426909604746 68.3952 52.234350000000006 42.21433279199533 5.51457;30.5985;43.719;105.624 1.34064;24.577;33.4848;83.8302 39.6721;40.5656;63.9031;129.44 0 0 Exp 2,2(0.5);Hill,1(0.25);Poly 2,1(0.25) 2.1998496440025113 9.157827496528625 1.6914535760879517 3.3687045574188232 0.7774944936568678 2.0488346815109253 4.647889072538604 88.08014592746139 1.7391762858734907 69.8771437141265 27.025153863844565 109.76524613615544 UP 1.0 0.0 0.0 GO:0001101 4 response to acid chemical 195 202 14 13 12 13 11 11 58 191 2287 0.99311 0.018028 0.021109 5.45 78968;25044;83792;362282;58827;24450;25086;29680;84032;24770;25612 srebf1;sds;scd2;pck1;mest;hmgcs2;cyp2e1;cyp11a1;col3a1;ccl2;asns SREBF1_32750;SDS_9798;SCD_9786;PCK1_9439;MEST_9219;HMGCS2_8812;CYP2E1_8421;CYP11A1_32785;COL3A1_8354;CCL2_8218;ASNS_8091 53.984269999999995 57.8774 5.51457 29.711445730430228 60.50868663300752 28.23978889234418 34.54093181818182 39.4215 1.34064 18.781725778113596 38.96633034466974 16.9061369358457 124.43250909090911 106.603 24.5771 95.18734243471086 142.73505180278428 99.55271488898731 9.5 91.29069999999999 11.2357;64.7394;83.9984;5.51457;96.9172;30.5985;49.5529;43.719;57.8774;64.0097;85.6642 4.94421;43.4259;54.1928;1.34064;56.7353;24.577;26.9979;33.4848;39.4215;41.1311;53.6991 24.5771;126.828;206.18;39.6721;331.492;40.5656;71.5977;63.9031;106.603;132.851;224.488 7 4 7 78968;83792;362282;24450;25086;29680;25612 SREBF1_32750;SCD_9786;PCK1_9439;HMGCS2_8812;CYP2E1_8421;CYP11A1_32785;ASNS_8091 44.32618142857143 43.719 31.885666430661505 28.462350000000004 26.9979 20.936830516963 95.8548 63.9031 83.28802421296834 11.2357;83.9984;5.51457;30.5985;49.5529;43.719;85.6642 4.94421;54.1928;1.34064;24.577;26.9979;33.4848;53.6991 24.5771;206.18;39.6721;40.5656;71.5977;63.9031;224.488 4 25044;58827;84032;24770 SDS_9798;MEST_9219;COL3A1_8354;CCL2_8218 70.885925 64.37455 17.62489943827102 45.178450000000005 42.2785 7.877303446188487 174.4435 129.8395 105.29915588297314 64.7394;96.9172;57.8774;64.0097 43.4259;56.7353;39.4215;41.1311 126.828;331.492;106.603;132.851 0 Exp 2,6(0.55);Hill,2(0.19);Linear,2(0.19);Poly 2,1(0.1) 2.0352283668228646 23.06612277030945 1.559963583946228 3.3687045574188232 0.5722549144342545 1.9179565906524658 36.42592761499871 71.54261238500129 23.44164116819607 45.640222468167565 68.18038442653264 180.6846337552855 UP 0.6363636363636364 0.36363636363636365 0.0 GO:0019318 5 hexose metabolic process 48 54 4 4 4 4 4 4 65 50 2428 0.98575 0.05653 0.05653 7.41 25044;362282;316033;299691 sds;pck1;glb1;cry1 SDS_9798;PCK1_9439;GLB1_8712;CRY1_8386 43.3561675 50.9971 5.51457 28.492088664181125 45.600485156541076 20.632161188298156 28.625909999999998 32.65285 1.34064 21.438921182724346 29.19663443182501 15.885157184975814 88.72805 94.20605 39.6721 39.78641155893136 90.4423136349979 32.494693561195994 1.5 50.9971 64.7394;5.51457;65.9159;37.2548 43.4259;1.34064;47.8573;21.8798 126.828;39.6721;114.587;73.8251 2 2 2 362282;316033 PCK1_9439;GLB1_8712 35.715235 35.715235 42.710190035686445 24.59897 24.59897 32.89224572414903 77.12955 77.12955 52.97283380191211 5.51457;65.9159 1.34064;47.8573 39.6721;114.587 2 25044;299691 SDS_9798;CRY1_8386 50.9971 50.9971 19.434547038199792 32.65285 32.65285 15.23539341812346 100.32655 100.32655 37.47871001255251 64.7394;37.2548 43.4259;21.8798 126.828;73.8251 0 Exp 2,2(0.5);Hill,1(0.25);Linear,1(0.25) 2.0589047934852522 8.270683526992798 1.8622472286224365 2.3449018001556396 0.2217654414120594 2.031767249107361 15.433920609102508 71.2784143908975 7.615767240930143 49.636052759069855 49.73736667224727 127.71873332775272 CONFLICT 0.5 0.5 0.0 GO:0048525 5 negative regulation of viral process 30 32 5 5 5 5 5 5 64 27 2451 0.99983 0.0014382 0.0014382 15.62 84386;286918;24516;287562;29339 slpi;mx2;jun;ccl12;apcs SLPI_9890;MX2_9268;JUN_8938;CCL12_8217;APCS_8057 54.68579999999999 56.5193 25.5289 30.114046520851364 52.420071754421215 30.788204113897226 34.81474 38.6865 13.9582 17.00813921753346 33.285553423934886 17.56013395946356 197.6852 109.049 46.786 157.08040699813583 203.85553665092442 159.8296333354203 0.5 28.5947 2.5 57.1428 56.5193;31.6605;57.7663;25.5289;101.954 39.3315;23.5989;38.6865;13.9582;58.4986 100.108;46.786;109.049;336.862;395.621 0 5 0 5 84386;286918;24516;287562;29339 SLPI_9890;MX2_9268;JUN_8938;CCL12_8217;APCS_8057 54.68579999999999 56.5193 30.114046520851364 34.81474 38.6865 17.00813921753346 197.6852 109.049 157.08040699813583 56.5193;31.6605;57.7663;25.5289;101.954 39.3315;23.5989;38.6865;13.9582;58.4986 100.108;46.786;109.049;336.862;395.621 0 Exp 2,2(0.4);Linear,2(0.4);Poly 2,1(0.2) 1.7395236026406515 8.917870998382568 1.5230457782745361 2.6565301418304443 0.4897166026896175 1.5823365449905396 28.28967440149985 81.08192559850015 19.906448659215513 49.72303134078449 59.998152551383185 335.3722474486168 DOWN 0.0 1.0 0.0 GO:0046340 8 diacylglycerol catabolic process 1 1 1 1 1 1 1 1 68 0 2478 1.0 0.027091 0.027091 100.0 25649 apoa2 APOA2_33095 80.183 80.183 80.183 80.183 50.2978 50.2978 50.2978 50.2978 197.161 197.161 197.161 197.161 0.0 80.183 0.0 80.183 80.183 50.2978 197.161 1 0 1 25649 APOA2_33095 80.183 80.183 50.2978 50.2978 197.161 197.161 80.183 50.2978 197.161 0 0 Linear,1(1) 1.9712703227996826 1.9712703227996826 1.9712703227996826 1.9712703227996826 0.0 1.9712703227996826 80.183 80.183 50.2978 50.2978 197.161 197.161 UP 1.0 0.0 0.0 GO:0043170 4 macromolecule metabolic process 853 925 34 31 28 29 23 23 46 902 1576 0.34979 0.73974 0.70366 2.49 360847;360243;24825;78968;362282;114519;286918;290350;293502;24516;85430;362376;24367;171142;116663;299691;84032;297594;58919;24770;287562;29657;25649 ube2t;top2a;tf;srebf1;pck1;nfil3;mx2;loxl2;kif22;jun;herpud1;herc6;fgg;ehhadh;dusp6;cry1;col3a1;cdca3;ccnd1;ccl2;ccl12;arntl;apoa2 UBE2T_10125;TOP2A_10059;TF_10003;SREBF1_32750;PCK1_9439;NFIL3_9304;MX2_9268;LOXL2_9150;KIF22_8963;JUN_8938;HERPUD1_8795;HERC6_8794;FGG_8639;EHHADH_8534;DUSP6_8506;CRY1_8386;COL3A1_8354;CDCA3_8260;CCND1_8224;CCL2_8218;CCL12_8217;ARNTL_8086;APOA2_33095 39.44891608695652 37.2548 2.6193 24.33163343537207 41.80471141087302 21.518557289383832 26.19281056521739 25.6436 0.978353 15.504792508181499 27.919264329806378 13.775280305097803 93.28142043478259 71.7388 7.96997 87.68286875026214 106.2383068943159 93.05290849855722 10.9914;13.8391;51.412;11.2357;5.51457;33.1149;31.6605;65.4434;13.2391;57.7663;53.893;53.833;93.1824;32.6956;45.5478;37.2548;57.8774;2.6193;28.2655;64.0097;25.5289;38.2177;80.183 7.86591;9.31624;36.6131;4.94421;1.34064;25.603;23.5989;43.7615;9.02099;38.6865;37.9512;36.3389;51.338;25.6436;33.3115;21.8798;39.4215;0.978353;22.3101;41.1311;13.9582;27.1236;50.2978 18.2059;27.6952;86.0232;24.5771;39.6721;46.6318;46.786;129.393;25.4349;109.049;92.6554;98.3689;327.378;45.0542;71.7388;73.8251;106.603;7.96997;38.3337;132.851;336.862;63.2034;197.161 11 12 11 360847;360243;24825;78968;362282;293502;85430;171142;297594;58919;25649 UBE2T_10125;TOP2A_10059;TF_10003;SREBF1_32750;PCK1_9439;KIF22_8963;HERPUD1_8795;EHHADH_8534;CDCA3_8260;CCND1_8224;APOA2_33095 27.626206363636367 13.8391 24.699677880382275 18.75292209090909 9.31624 16.896348764177844 54.79842454545455 38.3337 54.140677556628596 10.9914;13.8391;51.412;11.2357;5.51457;13.2391;53.893;32.6956;2.6193;28.2655;80.183 7.86591;9.31624;36.6131;4.94421;1.34064;9.02099;37.9512;25.6436;0.978353;22.3101;50.2978 18.2059;27.6952;86.0232;24.5771;39.6721;25.4349;92.6554;45.0542;7.96997;38.3337;197.161 12 114519;286918;290350;24516;362376;24367;116663;299691;84032;24770;287562;29657 NFIL3_9304;MX2_9268;LOXL2_9150;JUN_8938;HERC6_8794;FGG_8639;DUSP6_8506;CRY1_8386;COL3A1_8354;CCL2_8218;CCL12_8217;ARNTL_8086 50.28640000000001 49.6904 19.014180837135008 33.012708333333336 34.8252 10.731853893260375 128.5575 102.48595 99.36479098135865 33.1149;31.6605;65.4434;57.7663;53.833;93.1824;45.5478;37.2548;57.8774;64.0097;25.5289;38.2177 25.603;23.5989;43.7615;38.6865;36.3389;51.338;33.3115;21.8798;39.4215;41.1311;13.9582;27.1236 46.6318;46.786;129.393;109.049;98.3689;327.378;71.7388;73.8251;106.603;132.851;336.862;63.2034 0 Exp 2,8(0.35);Exp 4,1(0.05);Hill,2(0.09);Linear,7(0.31);Poly 2,4(0.18);Power,1(0.05) 2.00361164865912 48.16954064369202 1.5089621543884277 4.897102355957031 0.7456999542130393 1.8943853378295898 29.504863360853378 49.39296881305967 19.85618402437422 32.52943710606057 57.44646211418618 129.11637875537906 CONFLICT 0.4782608695652174 0.5217391304347826 0.0 GO:0048513 4 animal organ development 418 452 20 19 18 19 17 17 52 435 2043 0.94861 0.090542 0.1487 3.76 360243;78968;24587;24516;24450;24440;81660;24309;24306;29680;84032;114851;58919;24770;289054;25612;25649 top2a;srebf1;nefh;jun;hmgcs2;hbb;gatm;dbp;cyp4a2;cyp11a1;col3a1;cdkn1a;ccnd1;ccl2;aspm;asns;apoa2 TOP2A_10059;SREBF1_32750;NEFH_33218;JUN_8938;HMGCS2_8812;HBB_8782;GATM_32792;DBP_8439;CYP4A2_8425;CYP11A1_32785;COL3A1_8354;CDKN1A_8271;CCND1_8224;CCL2_8218;ASPM_8092;ASNS_8091;APOA2_33095 50.380088235294124 54.5478 10.3235 25.761689351047078 54.06218769557212 23.384140909676503 33.51847941176471 38.6865 4.94421 15.371847695878358 35.7550021200444 12.94527555105911 107.79545882352943 94.4701 16.8623 84.22213535248659 117.34353368291407 83.48985575938634 13.8391;11.2357;79.3182;57.7663;30.5985;91.4283;37.423;50.6952;59.5671;43.719;57.8774;54.5478;28.2655;64.0097;10.3235;85.6642;80.183 9.31624;4.94421;39.4261;38.6865;24.577;54.7263;28.03;40.5862;43.4174;33.4848;39.4215;38.2987;22.3101;41.1311;7.4611;53.6991;50.2978 27.6952;24.5771;264.141;109.049;40.5656;277.036;55.6613;59.5346;99.5908;63.9031;106.603;94.4701;38.3337;132.851;16.8623;224.488;197.161 9 8 9 360243;78968;24450;24306;29680;58919;289054;25612;25649 TOP2A_10059;SREBF1_32750;HMGCS2_8812;CYP4A2_8425;CYP11A1_32785;CCND1_8224;ASPM_8092;ASNS_8091;APOA2_33095 40.37728888888889 30.5985 28.969537621329255 27.72308333333333 24.577 18.612211644405672 81.46408888888888 40.5656 77.71109256451818 13.8391;11.2357;30.5985;59.5671;43.719;28.2655;10.3235;85.6642;80.183 9.31624;4.94421;24.577;43.4174;33.4848;22.3101;7.4611;53.6991;50.2978 27.6952;24.5771;40.5656;99.5908;63.9031;38.3337;16.8623;224.488;197.161 8 24587;24516;24440;81660;24309;84032;114851;24770 NEFH_33218;JUN_8938;HBB_8782;GATM_32792;DBP_8439;COL3A1_8354;CDKN1A_8271;CCL2_8218 61.6332375 57.82185 16.865816788906628 40.0383 39.4238 7.241150477060169 137.41825 107.826 86.12418826684441 79.3182;57.7663;91.4283;37.423;50.6952;57.8774;54.5478;64.0097 39.4261;38.6865;54.7263;28.03;40.5862;39.4215;38.2987;41.1311 264.141;109.049;277.036;55.6613;59.5346;106.603;94.4701;132.851 0 Exp 2,9(0.53);Hill,1(0.06);Linear,4(0.24);Poly 2,3(0.18) 2.027137320159285 36.94908690452576 1.5230457782745361 5.737884044647217 1.0440469256101645 1.7671042680740356 38.13375847494795 62.626417995640296 26.21116686155369 40.825791961975725 67.75879707389387 147.83212057316496 CONFLICT 0.5294117647058824 0.47058823529411764 0.0 GO:0010638 7 positive regulation of organelle organization 145 155 2 2 2 2 2 2 67 153 2325 0.19738 0.93074 0.43786 1.29 78968;81639 srebf1;alox15 SREBF1_32750;ALOX15_8036 58.429849999999995 58.429849999999995 11.2357 66.7426069946702 84.02482163071213 56.074686293291755 44.387205 44.387205 4.94421 55.780818469614175 65.77846510438414 46.864994307406235 77.00855 77.00855 24.5771 74.14926768488682 105.44388521224772 62.297490486689846 11.2357;105.624 4.94421;83.8302 24.5771;129.44 2 0 2 78968;81639 SREBF1_32750;ALOX15_8036 58.429849999999995 58.429849999999995 66.7426069946702 44.387205 44.387205 55.780818469614175 77.00855 77.00855 74.14926768488682 11.2357;105.624 4.94421;83.8302 24.5771;129.44 0 0 Hill,1(0.5);Poly 2,1(0.5) 2.1984522774263504 4.548873066902161 1.6914535760879517 2.857419490814209 0.8244624049353124 2.2744365334510803 -34.070683999999986 150.930384 -32.921065199999994 121.6954752 -25.75709199999997 179.77419199999997 UP 1.0 0.0 0.0 GO:0060395 5 SMAD protein signal transduction 24 24 2 2 2 2 2 2 67 22 2456 0.97437 0.1364 0.1364 8.33 24825;24516 tf;jun TF_10003;JUN_8938 54.589150000000004 54.589150000000004 51.412 4.493168619693547 54.95912379912664 4.462600477403196 37.6498 37.6498 36.6131 1.4661152001124398 37.77052197962155 1.4561408542005825 97.5361 97.5361 86.0232 16.281699322245256 98.87675793304223 16.170930877137057 0.5 54.589150000000004 51.412;57.7663 36.6131;38.6865 86.0232;109.049 1 1 1 24825 TF_10003 51.412 51.412 36.6131 36.6131 86.0232 86.0232 51.412 36.6131 86.0232 1 24516 JUN_8938 57.7663 57.7663 38.6865 38.6865 109.049 109.049 57.7663 38.6865 109.049 0 Exp 2,1(0.5);Linear,1(0.5) 1.7474383106923277 3.5279366970062256 1.5230457782745361 2.0048909187316895 0.34071596629903755 1.7639683485031128 48.361936 60.81636400000001 35.617868 39.681732 74.970816 120.10138400000001 CONFLICT 0.5 0.5 0.0 GO:0006475 9 internal protein amino acid acetylation 15 15 2 2 2 2 2 2 67 13 2465 0.99314 0.060519 0.060519 13.33 362282;171142 pck1;ehhadh PCK1_9439;EHHADH_8534 19.105085 19.105085 5.51457 19.219890632634982 24.029640678397776 17.91372933454032 13.49212 13.49212 1.34064 17.184787818905416 17.895237897661495 16.01692972886458 42.363150000000005 42.363150000000005 39.6721 3.805719407024048 43.33825841630007 3.5470871652557032 0.0 5.51457 0.5 19.105085 5.51457;32.6956 1.34064;25.6436 39.6721;45.0542 2 0 2 362282;171142 PCK1_9439;EHHADH_8534 19.105085 19.105085 19.219890632634982 13.49212 13.49212 17.184787818905416 42.363150000000005 42.363150000000005 3.805719407024048 5.51457;32.6956 1.34064;25.6436 39.6721;45.0542 0 0 Exp 2,1(0.5);Hill,1(0.5) 2.063090972865079 4.16005003452301 1.8151482343673706 2.3449018001556396 0.3745923387266389 2.080025017261505 -7.532324399999997 45.7424944 -10.3247808 37.3090208 37.088692 47.63760800000001 UP 1.0 0.0 0.0 GO:0006575 4 cellular modified amino acid metabolic process 61 71 4 4 3 4 3 3 66 68 2410 0.87598 0.30189 0.44028 4.23 29142;24440;81660 vnn1;hbb;gatm VNN1_10157;HBB_8782;GATM_32792 49.90656666666666 37.423 20.8684 36.899247276107594 44.35123098562628 27.68596931689378 33.2919 28.03 17.1194 19.347749884934945 31.023239952087607 14.27656467367199 119.74823333333332 55.6613 26.5474 136.99082432974603 90.19240973990416 106.81271047951093 20.8684;91.4283;37.423 17.1194;54.7263;28.03 26.5474;277.036;55.6613 1 2 1 29142 VNN1_10157 20.8684 20.8684 17.1194 17.1194 26.5474 26.5474 20.8684 17.1194 26.5474 2 24440;81660 HBB_8782;GATM_32792 64.42564999999999 64.42564999999999 38.18751385001387 41.378150000000005 41.378150000000005 18.877134762590405 166.34865 166.34865 156.53555155313765 91.4283;37.423 54.7263;28.03 277.036;55.6613 0 Exp 2,2(0.67);Linear,1(0.34) 2.1634627353093774 6.580894827842712 1.7553097009658813 2.642244338989258 0.44355686082522333 2.1833407878875732 8.151137585066316 91.66199574826703 11.397859935609748 55.18594006439025 -35.2714777011104 274.7679443677771 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0048609 3 multicellular organismal reproductive process 128 145 6 5 5 5 4 4 65 141 2337 0.64371 0.56024 1.0 2.76 29680;24770;289054;29657 cyp11a1;ccl2;aspm;arntl CYP11A1_32785;CCL2_8218;ASPM_8092;ARNTL_8086 39.067475 40.96835 10.3235 22.141134336550284 38.69109796714008 19.357722627602065 27.300150000000002 30.3042 7.4611 14.412542550732216 26.967734878863826 12.480939018999244 69.20495 63.553250000000006 16.8623 47.80063076797908 68.11736688248399 42.11069401662941 43.719;64.0097;10.3235;38.2177 33.4848;41.1311;7.4611;27.1236 63.9031;132.851;16.8623;63.2034 2 2 2 29680;289054 CYP11A1_32785;ASPM_8092 27.021250000000002 27.021250000000002 23.614184511115344 20.47295 20.47295 18.401534741564358 40.3827 40.3827 33.26286867244016 43.719;10.3235 33.4848;7.4611 63.9031;16.8623 2 24770;29657 CCL2_8218;ARNTL_8086 51.113699999999994 51.113699999999994 18.23769810036345 34.12735 34.12735 9.904798237470564 98.0272 98.0272 49.24829025336826 64.0097;38.2177 41.1311;27.1236 132.851;63.2034 0 Exp 2,2(0.5);Poly 2,1(0.25);Power,1(0.25) 2.1327823089478577 9.755116939544678 1.5452834367752075 4.897102355957031 1.6416065577474341 1.6563655734062195 17.369163350180706 60.7657866498193 13.17585830028243 41.424441699717576 22.36033184738052 116.04956815261947 CONFLICT 0.5 0.5 0.0 GO:1903901 6 negative regulation of viral life cycle 23 24 4 4 4 4 4 4 65 20 2458 0.99964 0.0034817 0.0034817 16.67 84386;286918;287562;29339 slpi;mx2;ccl12;apcs SLPI_9890;MX2_9268;CCL12_8217;APCS_8057 53.91567499999999 44.0899 25.5289 34.71580495551222 51.58660099596388 34.08622599495227 33.8468 31.4652 13.9582 19.479639299364177 32.44355214146752 19.317978988799062 219.84425 218.485 46.786 172.12064287658822 218.6357653241964 171.28029396361967 0.5 28.5947 1.5 44.0899 56.5193;31.6605;25.5289;101.954 39.3315;23.5989;13.9582;58.4986 100.108;46.786;336.862;395.621 0 4 0 4 84386;286918;287562;29339 SLPI_9890;MX2_9268;CCL12_8217;APCS_8057 53.91567499999999 44.0899 34.71580495551222 33.8468 31.4652 19.479639299364177 219.84425 218.485 172.12064287658822 56.5193;31.6605;25.5289;101.954 39.3315;23.5989;13.9582;58.4986 100.108;46.786;336.862;395.621 0 Exp 2,1(0.25);Linear,2(0.5);Poly 2,1(0.25) 1.7982897463860497 7.394825220108032 1.5314651727676392 2.6565301418304443 0.5398906002922211 1.6034149527549744 19.894186143598034 87.93716385640197 14.756753486623104 52.9368465133769 51.16601998094359 388.5224800190564 DOWN 0.0 1.0 0.0 GO:0032386 6 regulation of intracellular transport 104 109 7 7 6 6 5 5 64 104 2374 0.92788 0.17052 0.21741 4.59 78968;24587;100911740;361921;24770 srebf1;nefh;mrln;ect2;ccl2 SREBF1_32750;NEFH_33218;LOC100911740_32571;ECT2_8523;CCL2_8218 51.996159999999996 64.0097 11.2357 37.03434688479062 56.33561928433925 34.26759230453599 29.932071999999998 39.4261 4.94421 21.566828139301574 30.68410107745442 18.230568564827337 144.99588 132.851 24.5771 120.9559937917795 167.1776131412071 119.78577732854883 11.2357;79.3182;91.003;14.4142;64.0097 4.94421;39.4261;54.5666;9.59235;41.1311 24.5771;264.141;273.335;30.0753;132.851 2 3 2 78968;361921 SREBF1_32750;ECT2_8523 12.82495 12.82495 2.247538904001446 7.26828 7.26828 3.286731313904439 27.3262 27.3262 3.8878145043198633 11.2357;14.4142 4.94421;9.59235 24.5771;30.0753 3 24587;100911740;24770 NEFH_33218;LOC100911740_32571;CCL2_8218 78.1103 79.3182 13.53712776145669 45.041266666666665 41.1311 8.293113865330316 223.44233333333332 264.141 78.5889602001028 79.3182;91.003;64.0097 39.4261;54.5666;41.1311 264.141;273.335;132.851 0 Exp 2,2(0.4);Hill,1(0.2);Linear,1(0.2);Poly 2,1(0.2) 1.9105828268270393 9.780253052711487 1.559963583946228 2.857419490814209 0.5137464335933598 1.7797720432281494 19.534123682413842 84.45819631758616 11.027913638814827 48.83623036118517 38.97327683345111 251.0184831665489 DOWN 0.4 0.6 0.0 GO:0050728 7 negative regulation of inflammatory response 47 48 3 3 1 3 1 1 68 47 2431 0.62431 0.73573 1.0 2.08 84386 slpi SLPI_9890 56.5193 56.5193 56.5193 56.5193 39.3315 39.3315 39.3315 39.3315 100.108 100.108 100.108 100.108 56.5193 39.3315 100.108 0 1 0 1 84386 SLPI_9890 56.5193 56.5193 39.3315 39.3315 100.108 100.108 56.5193 39.3315 100.108 0 Linear,1(1) 1.5823365449905396 1.5823365449905396 1.5823365449905396 1.5823365449905396 0.0 1.5823365449905396 56.5193 56.5193 39.3315 39.3315 100.108 100.108 DOWN 0.0 1.0 0.0 GO:0035556 5 intracellular signal transduction 318 334 7 7 7 7 7 7 62 327 2151 0.29826 0.82022 0.58766 2.1 24825;360918;299923;24516;361921;114851;24770 tf;pf4;ndrg1;jun;ect2;cdkn1a;ccl2 TF_10003;PF4_32963;NDRG1_32364;JUN_8938;ECT2_8523;CDKN1A_8271;CCL2_8218 63.94772857142857 57.7663 14.4142 31.00062849619418 65.09050211486334 28.950420440739656 37.24692142857143 38.6865 9.59235 13.46195828689921 37.23524604416084 11.113374416524367 95.39322857142858 105.409 30.0753 32.28695172298528 95.38676016489723 27.366305029495354 51.412;105.82;99.6641;57.7663;14.4142;54.5478;64.0097 36.6131;53.8521;42.5546;38.6865;9.59235;38.2987;41.1311 86.0232;109.875;105.409;109.049;30.0753;94.4701;132.851 2 5 2 24825;361921 TF_10003;ECT2_8523 32.9131 32.9131 26.161395268983636 23.102725 23.102725 19.106555557746415 58.04925 58.04925 39.561139483146846 51.412;14.4142 36.6131;9.59235 86.0232;30.0753 5 360918;299923;24516;114851;24770 PF4_32963;NDRG1_32364;JUN_8938;CDKN1A_8271;CCL2_8218 76.36158 64.0097 24.418232547360994 42.9046 41.1311 6.366361616339465 110.33081999999999 109.049 14.007106166585661 105.82;99.6641;57.7663;54.5478;64.0097 53.8521;42.5546;38.6865;38.2987;41.1311 109.875;105.409;109.049;94.4701;132.851 0 Exp 2,2(0.29);Exp 3,2(0.29);Linear,2(0.29);Poly 2,1(0.15) 1.690972611087658 11.894699215888977 1.5226441621780396 2.0048909187316895 0.1837153606382491 1.6645443439483643 40.98214159489159 86.91331554796557 27.27416316819452 47.21967968894835 71.4747200130457 119.31173712981143 DOWN 0.2857142857142857 0.7142857142857143 0.0 GO:0090276 6 regulation of peptide hormone secretion 58 63 3 3 3 3 3 3 66 60 2418 0.91097 0.24237 0.24237 4.76 78968;24367;29657 srebf1;fgg;arntl SREBF1_32750;FGG_8639;ARNTL_8086 47.54526666666667 38.2177 11.2357 41.762040601045015 44.23815417903734 32.10494671102372 27.801936666666666 27.1236 4.94421 23.204332421253433 27.948857933423305 17.404964107773754 138.38616666666667 63.2034 24.5771 164.8072588296502 108.30245404408457 133.91926230669347 11.2357;93.1824;38.2177 4.94421;51.338;27.1236 24.5771;327.378;63.2034 1 2 1 78968 SREBF1_32750 11.2357 11.2357 4.94421 4.94421 24.5771 24.5771 11.2357 4.94421 24.5771 2 24367;29657 FGG_8639;ARNTL_8086 65.70005 65.70005 38.86591209588424 39.2308 39.2308 17.122166442363515 195.2907 195.2907 186.79965107724368 93.1824;38.2177 51.338;27.1236 327.378;63.2034 0 Exp 2,1(0.34);Hill,1(0.34);Power,1(0.34) 2.989271215171377 9.66342008113861 1.9088982343673706 4.897102355957031 1.5269448056262631 2.857419490814209 0.28706891614066876 94.80346441719267 1.5437626299052525 54.06011070342809 -48.110803222751 324.8831365560843 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0043410 8 positive regulation of MAPK cascade 143 153 8 8 7 7 7 7 62 146 2332 0.94807 0.1169 0.1895 4.58 24825;29692;24516;24367;24770;287562;81639 tf;pla2g2a;jun;fgg;ccl2;ccl12;alox15 TF_10003;PLA2G2A_32641;JUN_8938;FGG_8639;CCL2_8218;CCL12_8217;ALOX15_8036 56.78904285714303 57.7663 1.16694E-12 36.50006144820628 55.450632170022466 35.867932055180965 37.93672857142874 38.6865 1.16694E-12 26.809476438485323 38.244133628635446 28.77822733001259 160.22902857142873 129.44 1.16694E-12 125.58844684765258 182.87194698881441 126.20384123689907 51.412;1.16694E-12;57.7663;93.1824;64.0097;25.5289;105.624 36.6131;1.16694E-12;38.6865;51.338;41.1311;13.9582;83.8302 86.0232;1.16694E-12;109.049;327.378;132.851;336.862;129.44 2 5 2 24825;81639 TF_10003;ALOX15_8036 78.518 78.518 38.333672821685106 60.221650000000004 60.221650000000004 33.38753159796333 107.7316 107.7316 30.700313697420064 51.412;105.624 36.6131;83.8302 86.0232;129.44 5 29692;24516;24367;24770;287562 PLA2G2A_32641;JUN_8938;FGG_8639;CCL2_8218;CCL12_8217 48.09746000000023 57.7663 36.06259565842387 29.022760000000233 38.6865 21.25577139632865 181.22800000000024 132.851 146.60789082617586 1.16694E-12;57.7663;93.1824;64.0097;25.5289 1.16694E-12;38.6865;51.338;41.1311;13.9582 1.16694E-12;109.049;327.378;132.851;336.862 0 Exp 2,3(0.43);Hill,1(0.15);Linear,1(0.15);Poly 2,2(0.29) 1.7324146557646318 12.208076238632202 1.5230457782745361 2.0048909187316895 0.21817010058141864 1.6914535760879517 29.74941893659465 83.8286667776914 18.07599048932696 57.79746665353052 67.1918051589409 253.26625198391662 DOWN 0.2857142857142857 0.7142857142857143 0.0 GO:0006357 8 regulation of transcription by RNA polymerase II 343 364 19 19 17 18 16 16 53 348 2130 0.9856 0.030082 0.052384 4.4 360243;78968;360918;362282;316351;114519;366960;290350;24516;24309;299691;498709;306575;58919;282840;29657 top2a;srebf1;pf4;pck1;npas2;nfil3;maff;loxl2;jun;dbp;cry1;cks2;ckap2;ccnd1;atf5;arntl TOP2A_10059;SREBF1_32750;PF4_32963;PCK1_9439;NPAS2_9350;NFIL3_9304;MAFF_9172;LOXL2_9150;JUN_8938;DBP_8439;CRY1_8386;CKS2_8325;CKAP2_8324;CCND1_8224;ATF5_8097;ARNTL_8086 42.997854375 37.73625 5.51457 30.124269218816014 49.911721040076614 26.609483784126486 28.664645625000002 26.363300000000002 1.34064 20.009965918637633 34.20524524354687 19.33883014843327 68.2021875 61.369 21.3803 37.59396600368868 79.81529667266958 34.9610149655796 13.8391;11.2357;105.82;5.51457;58.2312;33.1149;58.0695;65.4434;57.7663;50.6952;37.2548;14.4197;12.1218;28.2655;97.9563;38.2177 9.31624;4.94421;53.8521;1.34064;35.795;25.603;40.1293;43.7615;38.6865;40.5862;21.8798;9.6236;8.47044;22.3101;75.2121;27.1236 27.6952;24.5771;109.875;39.6721;99.4319;46.6318;104.733;129.393;109.049;59.5346;73.8251;29.0958;21.3803;38.3337;114.804;63.2034 7 9 7 360243;78968;362282;366960;498709;306575;58919 TOP2A_10059;SREBF1_32750;PCK1_9439;MAFF_9172;CKS2_8325;CKAP2_8324;CCND1_8224 20.495124285714287 13.8391 17.952216172415273 13.733504285714288 9.31624 13.324377329821525 40.78388571428572 29.0958 28.993714199772594 13.8391;11.2357;5.51457;58.0695;14.4197;12.1218;28.2655 9.31624;4.94421;1.34064;40.1293;9.6236;8.47044;22.3101 27.6952;24.5771;39.6721;104.733;29.0958;21.3803;38.3337 9 360918;316351;114519;290350;24516;24309;299691;282840;29657 PF4_32963;NPAS2_9350;NFIL3_9304;LOXL2_9150;JUN_8938;DBP_8439;CRY1_8386;ATF5_8097;ARNTL_8086 60.49997777777779 57.7663 25.92501833113033 40.27775555555556 38.6865 16.455983263779107 89.52753333333334 99.4319 29.155842330097443 105.82;58.2312;33.1149;65.4434;57.7663;50.6952;37.2548;97.9563;38.2177 53.8521;35.795;25.603;43.7615;38.6865;40.5862;21.8798;75.2121;27.1236 109.875;99.4319;46.6318;129.393;109.049;59.5346;73.8251;114.804;63.2034 0 Exp 2,2(0.13);Exp 3,1(0.07);Hill,2(0.13);Linear,4(0.25);Poly 2,5(0.32);Power,2(0.13) 2.427683192722111 42.53960382938385 1.5230457782745361 5.737884044647217 1.3112537100499821 2.2254363298416138 28.236962457780148 57.75874629221984 18.85976232486756 38.46952892513244 49.78114415819256 86.62323084180746 CONFLICT 0.4375 0.5625 0.0 GO:0034097 5 response to cytokine 230 247 13 13 13 12 12 12 57 235 2243 0.98673 0.030729 0.03758 4.86 362282;114519;24587;286918;24516;79438;24367;29680;84032;24770;287562;81639 pck1;nfil3;nefh;mx2;jun;igfals;fgg;cyp11a1;col3a1;ccl2;ccl12;alox15 PCK1_9439;NFIL3_9304;NEFH_33218;MX2_9268;JUN_8938;IGFALS_8880;FGG_8639;CYP11A1_32785;COL3A1_8354;CCL2_8218;CCL12_8217;ALOX15_8036 55.640180833333325 57.82185 5.51457 29.246096827366248 56.57138619460948 29.093442725318347 36.488736666666675 39.054 1.34064 20.523489020936395 37.1112855434427 21.51829287829848 146.00941666666668 119.2445 39.6721 106.35233230215016 166.73210513562384 112.00209349035188 5.51457;33.1149;79.3182;31.6605;57.7663;70.3663;93.1824;43.719;57.8774;64.0097;25.5289;105.624 1.34064;25.603;39.4261;23.5989;38.6865;46.0459;51.338;33.4848;39.4215;41.1311;13.9582;83.8302 39.6721;46.6318;264.141;46.786;109.049;148.796;327.378;63.9031;106.603;132.851;336.862;129.44 3 9 3 362282;29680;81639 PCK1_9439;CYP11A1_32785;ALOX15_8036 51.61919 43.719 50.520137027311186 39.551880000000004 33.4848 41.5781068838301 77.67173333333334 63.9031 46.44082703293875 5.51457;43.719;105.624 1.34064;33.4848;83.8302 39.6721;63.9031;129.44 9 114519;24587;286918;24516;79438;24367;84032;24770;287562 NFIL3_9304;NEFH_33218;MX2_9268;JUN_8938;IGFALS_8880;FGG_8639;COL3A1_8354;CCL2_8218;CCL12_8217 56.9805111111111 57.8774 23.02019226773775 35.46768888888889 39.4215 11.928643495327165 168.78864444444446 132.851 112.59737328347309 33.1149;79.3182;31.6605;57.7663;70.3663;93.1824;57.8774;64.0097;25.5289 25.603;39.4261;23.5989;38.6865;46.0459;51.338;39.4215;41.1311;13.9582 46.6318;264.141;46.786;109.049;148.796;327.378;106.603;132.851;336.862 0 Exp 2,7(0.59);Hill,1(0.09);Linear,2(0.17);Poly 2,2(0.17) 1.845474825734787 22.688729405403137 1.5230457782745361 2.835543394088745 0.46280310197177715 1.7221105694770813 39.09264379482809 72.18771787183857 24.876479593937667 48.10099373939567 85.83491993674758 206.18391339658578 DOWN 0.25 0.75 0.0 GO:0048285 6 organelle fission 20 20 3 3 3 3 3 3 66 17 2461 0.99828 0.015593 0.015593 15.0 360243;286918;498709 top2a;mx2;cks2 TOP2A_10059;MX2_9268;CKS2_8325 19.9731 14.4197 13.8391 10.12574753586124 26.08394558900818 9.982343599624853 14.179580000000001 9.6236 9.31624 8.158817897783962 19.100431850739547 8.051605413263527 34.525666666666666 29.0958 27.6952 10.640829393112817 40.956340160672724 10.44430790741931 0.0 13.8391 1.0 14.4197 13.8391;31.6605;14.4197 9.31624;23.5989;9.6236 27.6952;46.786;29.0958 2 1 2 360243;498709 TOP2A_10059;CKS2_8325 14.1294 14.1294 0.41054619715692914 9.46992 9.46992 0.21733634026544935 28.3955 28.3955 0.990373757730037 13.8391;14.4197 9.31624;9.6236 27.6952;29.0958 1 286918 MX2_9268 31.6605 31.6605 23.5989 23.5989 46.786 46.786 31.6605 23.5989 46.786 0 Exp 2,1(0.34);Poly 2,2(0.67) 1.9748718003845371 6.081416606903076 1.530501127243042 2.6565301418304443 0.5746328918930723 1.8943853378295898 8.514737991471675 31.431462008528328 4.947008409272765 23.412151590727234 22.484434666218135 46.5668986671152 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0045931 7 positive regulation of mitotic cell cycle 58 63 2 2 2 2 2 2 67 61 2417 0.75763 0.51452 0.68795 3.17 58919;25612 ccnd1;asns CCND1_8224;ASNS_8091 56.96485 56.96485 28.2655 40.58701000129228 54.048625725806446 40.376932186710384 38.004599999999996 38.004599999999996 22.3101 22.19537475466455 36.40983629032257 22.080491795261075 131.41085 131.41085 38.3337 131.63096787703492 121.95301056451612 130.94964776840834 28.2655;85.6642 22.3101;53.6991 38.3337;224.488 2 0 2 58919;25612 CCND1_8224;ASNS_8091 56.96485 56.96485 40.58701000129228 38.004599999999996 38.004599999999996 22.19537475466455 131.41085 131.41085 131.63096787703492 28.2655;85.6642 22.3101;53.6991 38.3337;224.488 0 0 Exp 2,1(0.5);Linear,1(0.5) 1.9023428461044856 3.863510251045227 1.5959433317184448 2.2675669193267822 0.47490959320269266 1.9317551255226135 0.7141240000000124 113.21557599999998 7.243379999999998 68.76581999999999 -51.02036399999997 313.842064 UP 1.0 0.0 0.0 GO:0002544 6 chronic inflammatory response 13 14 2 2 2 2 2 2 67 12 2466 0.99441 0.053364 0.053364 14.29 29142;24770 vnn1;ccl2 VNN1_10157;CCL2_8218 42.439049999999995 42.439049999999995 20.8684 30.50550577920321 44.517285382059804 30.363592643798086 29.12525 29.12525 17.1194 16.978835897817035 30.281959800664453 16.89984950581199 79.6992 79.6992 26.5474 75.16799642454228 84.82013754152824 74.81831115356411 0.0 20.8684 0.5 42.439049999999995 20.8684;64.0097 17.1194;41.1311 26.5474;132.851 1 1 1 29142 VNN1_10157 20.8684 20.8684 17.1194 17.1194 26.5474 26.5474 20.8684 17.1194 26.5474 1 24770 CCL2_8218 64.0097 64.0097 41.1311 41.1311 132.851 132.851 64.0097 41.1311 132.851 0 Exp 2,2(1) 2.0302228815357477 4.202207922935486 1.559963583946228 2.642244338989258 0.7652880610386231 2.101103961467743 0.16057599999999894 84.717524 5.593783999999996 52.656716 -24.47832799999999 183.876728 CONFLICT 0.5 0.5 0.0 GO:0009617 5 response to bacterium 110 127 12 12 12 12 12 12 57 115 2363 0.99998 1.0862E-4 1.0862E-4 9.45 24825;84386;29692;362282;314654;24450;362376;360504;81714;170568;25086;24770 tf;slpi;pla2g2a;pck1;myo1f;hmgcs2;herc6;hba-a2;gas5;dmbt1;cyp2e1;ccl2 TF_10003;SLPI_9890;PLA2G2A_32641;PCK1_9439;MYO1F_32715;HMGCS2_8812;HERC6_8794;HBA2_32600;GAS5_8688;DMBT1_32993;CYP2E1_8421;CCL2_8218 47.1894725000001 50.48245 1.16694E-12 30.634553537402393 47.36459990739156 25.086889669693203 32.90620333333343 33.2259 1.16694E-12 23.75879687326051 32.55354161753337 18.27221087483507 84.56050833333343 92.19605 1.16694E-12 44.87746257063782 90.44786478513113 42.512830160625164 5.5 50.48245 51.412;56.5193;1.16694E-12;5.51457;91.9576;30.5985;53.833;101.406;39.7267;21.7434;49.5529;64.0097 36.6131;39.3315;1.16694E-12;1.34064;61.1322;24.577;36.3389;84.6435;30.1129;12.6557;26.9979;41.1311 86.0232;100.108;1.16694E-12;39.6721;110.707;40.5656;98.3689;115.953;58.3946;160.485;71.5977;132.851 8 4 8 24825;362282;314654;24450;360504;81714;170568;25086 TF_10003;PCK1_9439;MYO1F_32715;HMGCS2_8812;HBA2_32600;GAS5_8688;DMBT1_32993;CYP2E1_8421 48.98895875 44.6398 33.072174022196805 34.7591175 28.5554 26.668020987127605 85.424775 78.81045 41.80401574533755 51.412;5.51457;91.9576;30.5985;101.406;39.7267;21.7434;49.5529 36.6131;1.34064;61.1322;24.577;84.6435;30.1129;12.6557;26.9979 86.0232;39.6721;110.707;40.5656;115.953;58.3946;160.485;71.5977 4 84386;29692;362376;24770 SLPI_9890;PLA2G2A_32641;HERC6_8794;CCL2_8218 43.59050000000029 55.17615 29.37764509838446 29.200375000000292 37.8352 19.56699885101981 82.83197500000028 99.23845 57.45402806478502 56.5193;1.16694E-12;53.833;64.0097 39.3315;1.16694E-12;36.3389;41.1311 100.108;1.16694E-12;98.3689;132.851 0 Exp 2,4(0.34);Hill,2(0.17);Linear,2(0.17);Poly 2,4(0.34) 1.8637504431863847 23.031997323036194 1.5059963464736938 3.3687045574188232 0.5384755917138515 1.6889758110046387 29.85634212330328 64.52260287669691 19.463398518342796 46.349008148324046 59.16869353954244 109.95232312712443 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0006979 4 response to oxidative stress 170 179 11 11 10 9 9 9 60 170 2308 0.97957 0.049501 0.055604 5.03 287877;24587;24516;24440;360504;81660;361921;25086;29680 pycr1;nefh;jun;hbb;hba-a2;gatm;ect2;cyp2e1;cyp11a1 PYCR1_9631;NEFH_33218;JUN_8938;HBB_8782;HBA2_32600;GATM_32792;ECT2_8523;CYP2E1_8421;CYP11A1_32785 58.860011111111106 54.7122 14.4142 27.519631062908744 54.94531749358427 23.437484345399216 39.33033888888889 38.3856 9.59235 20.88641734087877 35.20393516538352 14.460148127231367 120.26074444444446 94.9303 30.0753 89.3844775246115 121.66451672607165 91.21395912791142 7.5 96.41714999999999 54.7122;79.3182;57.7663;91.4283;101.406;37.423;14.4142;49.5529;43.719 38.3856;39.4261;38.6865;54.7263;84.6435;28.03;9.59235;26.9979;33.4848 94.9303;264.141;109.049;277.036;115.953;55.6613;30.0753;71.5977;63.9031 5 4 5 287877;360504;361921;25086;29680 PYCR1_9631;HBA2_32600;ECT2_8523;CYP2E1_8421;CYP11A1_32785 52.76086 49.5529 31.35550169504548 38.62083 33.4848 27.93861773664724 75.29187999999999 71.5977 32.507247662667524 54.7122;101.406;14.4142;49.5529;43.719 38.3856;84.6435;9.59235;26.9979;33.4848 94.9303;115.953;30.0753;71.5977;63.9031 4 24587;24516;24440;81660 NEFH_33218;JUN_8938;HBB_8782;GATM_32792 66.48395 68.54225 23.857038139788756 40.217225 39.0563 10.985000505955085 176.47182500000002 186.59500000000003 110.96554693592581 79.3182;57.7663;91.4283;37.423 39.4261;38.6865;54.7263;28.03 264.141;109.049;277.036;55.6613 0 Exp 2,4(0.45);Linear,2(0.23);Poly 2,3(0.34) 1.8107682856889271 16.403147101402283 1.5230457782745361 2.2035675048828125 0.22574860405183925 1.7671042680740356 40.88051881667741 76.83950340554482 25.684546226181432 52.976131551596346 61.862885795031616 178.65860309385732 CONFLICT 0.5555555555555556 0.4444444444444444 0.0 GO:0009062 6 fatty acid catabolic process 37 42 3 3 3 3 3 3 66 39 2439 0.97455 0.10329 0.10329 7.14 362282;171142;29740 pck1;ehhadh;eci1 PCK1_9439;EHHADH_8534;ECI1_8520 47.147056666666664 32.6956 5.51457 50.43568798804704 59.974718903641886 49.63589782164811 25.66058 25.6436 1.34064 24.328434444188964 32.46466362923622 22.09635662070336 63.990100000000005 45.0542 39.6721 37.55551422907162 72.34150911734953 39.03309196247804 1.5 67.9633 5.51457;32.6956;103.231 1.34064;25.6436;49.9975 39.6721;45.0542;107.244 3 0 3 362282;171142;29740 PCK1_9439;EHHADH_8534;ECI1_8520 47.147056666666664 32.6956 50.43568798804704 25.66058 25.6436 24.328434444188964 63.990100000000005 45.0542 37.55551422907162 5.51457;32.6956;103.231 1.34064;25.6436;49.9975 39.6721;45.0542;107.244 0 0 Exp 2,1(0.34);Exp 3,1(0.34);Hill,1(0.34) 1.9027579147361982 5.778554320335388 1.618504285812378 2.3449018001556396 0.3757128850183239 1.8151482343673706 -9.926297085192694 104.22041041852603 -1.8696352236167364 53.190795223616746 21.49203495056974 106.48816504943025 UP 1.0 0.0 0.0 GO:0071705 5 nitrogen compound transport 239 254 7 7 7 7 7 7 62 247 2231 0.61801 0.54118 1.0 2.76 29503;286918;85430;24367;170568;114851;29657 slc22a2;mx2;herpud1;fgg;dmbt1;cdkn1a;arntl SLC22A2_9845;MX2_9268;HERPUD1_8795;FGG_8639;DMBT1_32993;CDKN1A_8271;ARNTL_8086 53.58095714285714 53.893 21.7434 26.13115459209927 44.4782858951323 20.145183918376834 33.9038 37.9512 12.6557 13.530589584099184 29.995755011978655 11.501373997028209 126.7224142857143 94.4701 46.786 95.42461499697771 100.06428328432975 72.94066292595701 81.8219;31.6605;53.893;93.1824;21.7434;54.5478;38.2177 46.3605;23.5989;37.9512;51.338;12.6557;38.2987;27.1236 102.079;46.786;92.6554;327.378;160.485;94.4701;63.2034 3 4 3 29503;85430;170568 SLC22A2_9845;HERPUD1_8795;DMBT1_32993 52.4861 53.893 30.063949611952182 32.322466666666664 37.9512 17.543242715169093 118.40646666666667 102.079 36.744432025183556 81.8219;53.893;21.7434 46.3605;37.9512;12.6557 102.079;92.6554;160.485 4 286918;24367;114851;29657 MX2_9268;FGG_8639;CDKN1A_8271;ARNTL_8086 54.4021 46.38275 27.58651887244929 35.0898 32.711149999999996 12.514021039085193 132.959375 78.83675 131.11289365022736 31.6605;93.1824;54.5478;38.2177 23.5989;51.338;38.2987;27.1236 46.786;327.378;94.4701;63.2034 0 Exp 2,2(0.29);Linear,2(0.29);Poly 2,2(0.29);Power,1(0.15) 2.0806792940302543 15.92572271823883 1.5270863771438599 4.897102355957031 1.2183892759073702 1.6717280149459839 34.22272691678727 72.93918736892701 23.880198963149958 43.92740103685005 56.03087021960975 197.41395835181885 CONFLICT 0.42857142857142855 0.5714285714285714 0.0 GO:0031399 7 regulation of protein modification process 444 469 21 21 19 18 17 17 52 452 2026 0.93022 0.11807 0.20586 3.62 24825;78968;29692;24516;85430;24440;24367;361921;116663;299691;498709;114851;58919;24770;287562;29657;81639 tf;srebf1;pla2g2a;jun;herpud1;hbb;fgg;ect2;dusp6;cry1;cks2;cdkn1a;ccnd1;ccl2;ccl12;arntl;alox15 TF_10003;SREBF1_32750;PLA2G2A_32641;JUN_8938;HERPUD1_8795;HBB_8782;FGG_8639;ECT2_8523;DUSP6_8506;CRY1_8386;CKS2_8325;CDKN1A_8271;CCND1_8224;CCL2_8218;CCL12_8217;ARNTL_8086;ALOX15_8036 46.27928235294125 45.5478 1.16694E-12 30.271081691488778 46.29989037871759 26.85285011642167 30.901085882353012 33.3115 1.16694E-12 21.045903458855033 31.722065553858304 20.332890230427868 112.74199411764711 86.0232 1.16694E-12 103.36213659467174 117.78352470183194 101.72866885533931 51.412;11.2357;1.16694E-12;57.7663;53.893;91.4283;93.1824;14.4142;45.5478;37.2548;14.4197;54.5478;28.2655;64.0097;25.5289;38.2177;105.624 36.6131;4.94421;1.16694E-12;38.6865;37.9512;54.7263;51.338;9.59235;33.3115;21.8798;9.6236;38.2987;22.3101;41.1311;13.9582;27.1236;83.8302 86.0232;24.5771;1.16694E-12;109.049;92.6554;277.036;327.378;30.0753;71.7388;73.8251;29.0958;94.4701;38.3337;132.851;336.862;63.2034;129.44 7 10 7 24825;78968;85430;361921;498709;58919;81639 TF_10003;SREBF1_32750;HERPUD1_8795;ECT2_8523;CKS2_8325;CCND1_8224;ALOX15_8036 39.89487142857143 28.2655 33.92086270363782 29.266394285714284 22.3101 27.445324112066807 61.45721428571428 38.3337 41.080001259551615 51.412;11.2357;53.893;14.4142;14.4197;28.2655;105.624 36.6131;4.94421;37.9512;9.59235;9.6236;22.3101;83.8302 86.0232;24.5771;92.6554;30.0753;29.0958;38.3337;129.44 10 29692;24516;24440;24367;116663;299691;114851;24770;287562;29657 PLA2G2A_32641;JUN_8938;HBB_8782;FGG_8639;DUSP6_8506;CRY1_8386;CDKN1A_8271;CCL2_8218;CCL12_8217;ARNTL_8086 50.748370000000115 50.0478 28.42653741582734 32.04537000000012 35.805099999999996 16.784935597006577 148.64134000000013 101.75955 119.96099858660715 1.16694E-12;57.7663;91.4283;93.1824;45.5478;37.2548;54.5478;64.0097;25.5289;38.2177 1.16694E-12;38.6865;54.7263;51.338;33.3115;21.8798;38.2987;41.1311;13.9582;27.1236 1.16694E-12;109.049;277.036;327.378;71.7388;73.8251;94.4701;132.851;336.862;63.2034 0 Exp 2,4(0.24);Hill,2(0.12);Linear,6(0.36);Poly 2,4(0.24);Power,1(0.06) 1.8956871011739076 33.917274713516235 1.5230457782745361 4.897102355957031 0.8221445225646723 1.7553097009658813 31.88932354454183 60.66924116134064 20.896498436651463 40.905673328054554 63.60675332565126 161.87723490964302 CONFLICT 0.4117647058823529 0.5882352941176471 0.0 GO:0009888 4 tissue development 153 164 7 7 6 5 5 5 64 159 2319 0.71743 0.46084 0.80124 3.05 24450;81660;170568;114851;81639 hmgcs2;gatm;dmbt1;cdkn1a;alox15 HMGCS2_8812;GATM_32792;DMBT1_32993;CDKN1A_8271;ALOX15_8036 49.98734 37.423 21.7434 33.34571049727384 50.52595589774667 31.467280499358115 37.47832 28.03 12.6557 27.482026285865462 37.87522324940774 25.83284721222145 96.12440000000001 94.4701 40.5656 49.94746105474233 90.63605271610382 46.545350294828836 30.5985;37.423;21.7434;54.5478;105.624 24.577;28.03;12.6557;38.2987;83.8302 40.5656;55.6613;160.485;94.4701;129.44 3 2 3 24450;170568;81639 HMGCS2_8812;DMBT1_32993;ALOX15_8036 52.655300000000004 30.5985 46.0854161722556 40.3543 24.577 38.12013587370852 110.16353333333335 129.44 62.24027835295507 30.5985;21.7434;105.624 24.577;12.6557;83.8302 40.5656;160.485;129.44 2 81660;114851 GATM_32792;CDKN1A_8271 45.9854 45.9854 12.109062206463422 33.16435 33.16435 7.261067403970299 75.06569999999999 75.06569999999999 27.44196564971254 37.423;54.5478 28.03;38.2987 55.6613;94.4701 0 Exp 2,2(0.4);Linear,1(0.2);Poly 2,2(0.4) 2.013923291081391 10.507876515388489 1.5998332500457764 3.3687045574188232 0.7455271825494586 1.6914535760879517 20.7585360314664 79.2161439685336 13.38926185762455 61.567378142375446 52.34352005700456 139.90527994299546 UP 0.6 0.4 0.0 GO:0071277 7 cellular response to calcium ion 24 25 3 3 3 3 3 3 66 22 2456 0.99594 0.028573 0.028573 12.0 24516;361921;81639 jun;ect2;alox15 JUN_8938;ECT2_8523;ALOX15_8036 59.268166666666666 57.7663 14.4142 45.62344360768193 67.5355688504874 44.46693387330233 44.036350000000006 38.6865 9.59235 37.40695476007769 50.725022236992025 37.054055040438506 89.52143333333333 109.049 30.0753 52.48171392459792 98.7349838587163 48.38770397914574 0.5 36.09025 1.5 81.69515 57.7663;14.4142;105.624 38.6865;9.59235;83.8302 109.049;30.0753;129.44 2 1 2 361921;81639 ECT2_8523;ALOX15_8036 60.019099999999995 60.019099999999995 64.49506809066877 46.711275 46.711275 52.49408715570975 79.75765 79.75765 70.26145318056693 14.4142;105.624 9.59235;83.8302 30.0753;129.44 1 24516 JUN_8938 57.7663 57.7663 38.6865 38.6865 109.049 109.049 57.7663 38.6865 109.049 0 Exp 2,1(0.34);Poly 2,2(0.67) 1.6612913613419125 4.994271397590637 1.5230457782745361 1.7797720432281494 0.130428596761722 1.6914535760879517 7.6403800680910265 110.8959532652423 1.7063958154217644 86.36630418457824 30.13278327601025 148.9100833906564 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0050670 7 regulation of lymphocyte proliferation 73 78 3 3 2 2 2 2 67 76 2402 0.64535 0.63201 1.0 2.56 29692;114851 pla2g2a;cdkn1a PLA2G2A_32641;CDKN1A_8271 27.273900000000584 27.273900000000584 1.16694E-12 38.571119278806734 41.51244432934481 32.89770437557209 19.14935000000058 19.14935000000058 1.16694E-12 27.0812704806284 29.146411984283183 23.097894150977883 47.235050000000584 47.235050000000584 1.16694E-12 66.80044832937044 71.89446260046465 56.97478948978255 1.16694E-12;54.5478 1.16694E-12;38.2987 1.16694E-12;94.4701 0 2 0 2 29692;114851 PLA2G2A_32641;CDKN1A_8271 27.273900000000584 27.273900000000584 38.571119278806734 19.14935000000058 19.14935000000058 27.0812704806284 47.235050000000584 47.235050000000584 66.80044832937044 1.16694E-12;54.5478 1.16694E-12;38.2987 1.16694E-12;94.4701 0 Hill,1(0.5);Linear,1(0.5) 1.8192613019220234 3.6529033184051514 1.6645443439483643 1.988358974456787 0.22897152107992208 1.8264516592025757 -26.18294399999827 80.73074399999943 -18.38337599999827 56.682075999999434 -45.34564799999826 139.81574799999942 DOWN 0.0 1.0 0.0 GO:0048821 6 erythrocyte development 8 9 3 2 2 3 2 2 67 7 2471 0.99858 0.023028 0.023028 22.22 24440;360504 hbb;hba-a2 HBB_8782;HBA2_32600 96.41714999999999 96.41714999999999 91.4283 7.055299330645103 94.91748058912387 6.728984467299607 69.6849 69.6849 54.7263 21.15465499411419 65.18828157099698 20.17623040431248 196.49450000000002 196.49450000000002 115.953 113.90288163387265 220.70561555891234 108.63475600049004 0.0 91.4283 0.0 91.4283 91.4283;101.406 54.7263;84.6435 277.036;115.953 1 1 1 360504 HBA2_32600 101.406 101.406 84.6435 84.6435 115.953 115.953 101.406 84.6435 115.953 1 24440 HBB_8782 91.4283 91.4283 54.7263 54.7263 277.036 277.036 91.4283 54.7263 277.036 0 Linear,1(0.5);Poly 2,1(0.5) 1.7666772279545555 3.5334280729293823 1.7553097009658813 1.778118371963501 0.016128165932269775 1.7667140364646912 86.63900399999999 106.195296 40.366044 99.003756 38.63316000000003 354.35584 CONFLICT 0.5 0.5 0.0 GO:2001020 6 regulation of response to DNA damage stimulus 41 44 2 2 2 2 2 2 67 42 2436 0.88522 0.33594 0.33594 4.55 316351;299691 npas2;cry1 NPAS2_9350;CRY1_8386 47.743 47.743 37.2548 14.832554684881517 46.02208245520193 14.631526375877938 28.837400000000002 28.837400000000002 21.8798 9.839532281567035 27.695787911206207 9.706175312523454 86.6285 86.6285 73.8251 18.10674192448764 84.52770141749131 17.861337960843226 58.2312;37.2548 35.795;21.8798 99.4319;73.8251 0 2 0 2 316351;299691 NPAS2_9350;CRY1_8386 47.743 47.743 14.832554684881517 28.837400000000002 28.837400000000002 9.839532281567035 86.6285 86.6285 18.10674192448764 58.2312;37.2548 35.795;21.8798 99.4319;73.8251 0 Exp 2,1(0.5);Power,1(0.5) 2.99628718581759 6.6831629276275635 1.8622472286224365 4.820915699005127 2.0920945386904304 3.3415814638137817 27.186128000000007 68.299872 15.200504 42.474296 61.533836000000015 111.723164 DOWN 0.0 1.0 0.0 GO:0045091 8 regulation of single stranded viral RNA replication via double stranded DNA intermediate 1 1 1 1 1 1 1 1 68 0 2478 1.0 0.027091 0.027091 100.0 360243 top2a TOP2A_10059 13.8391 13.8391 13.8391 13.8391 9.31624 9.31624 9.31624 9.31624 27.6952 27.6952 27.6952 27.695199999999996 0.0 13.8391 0.0 13.8391 13.8391 9.31624 27.6952 1 0 1 360243 TOP2A_10059 13.8391 13.8391 9.31624 9.31624 27.6952 27.6952 13.8391 9.31624 27.6952 0 0 Poly 2,1(1) 1.8943853378295898 1.8943853378295898 1.8943853378295898 1.8943853378295898 0.0 1.8943853378295898 13.8391 13.8391 9.31624 9.31624 27.6952 27.6952 UP 1.0 0.0 0.0 GO:0045870 8 positive regulation of single stranded viral RNA replication via double stranded DNA intermediate 1 1 1 1 1 1 1 1 68 0 2478 1.0 0.027091 0.027091 100.0 360243 top2a TOP2A_10059 13.8391 13.8391 13.8391 13.8391 9.31624 9.31624 9.31624 9.31624 27.6952 27.6952 27.6952 27.695199999999996 0.0 13.8391 0.0 13.8391 13.8391 9.31624 27.6952 1 0 1 360243 TOP2A_10059 13.8391 13.8391 9.31624 9.31624 27.6952 27.6952 13.8391 9.31624 27.6952 0 0 Poly 2,1(1) 1.8943853378295898 1.8943853378295898 1.8943853378295898 1.8943853378295898 0.0 1.8943853378295898 13.8391 13.8391 9.31624 9.31624 27.6952 27.6952 UP 1.0 0.0 0.0 GO:0051052 6 regulation of DNA metabolic process 84 88 2 2 2 2 2 2 67 86 2392 0.57086 0.69752 1.0 2.27 316351;114851 npas2;cdkn1a NPAS2_9350;CDKN1A_8271 56.3895 56.3895 54.5478 2.60455711782274 56.10638210248427 2.573597927457069 37.04685 37.04685 35.795 1.7703832480568824 37.23929238475597 1.7493395045272653 96.951 96.951 94.4701 3.508522426891847 96.5696201922426 3.4668182104733547 58.2312;54.5478 35.795;38.2987 99.4319;94.4701 0 2 0 2 316351;114851 NPAS2_9350;CDKN1A_8271 56.3895 56.3895 2.60455711782274 37.04685 37.04685 1.7703832480568824 96.951 96.951 3.508522426891847 58.2312;54.5478 35.795;38.2987 99.4319;94.4701 0 Linear,1(0.5);Power,1(0.5) 2.8327774285020806 6.485460042953491 1.6645443439483643 4.820915699005127 2.2318915891036086 3.2427300214767456 52.779768 59.999232 34.593224000000006 39.50047599999999 92.088436 101.81356399999999 DOWN 0.0 1.0 0.0 GO:0010999 6 regulation of eIF2 alpha phosphorylation by heme 1 1 1 1 1 1 1 1 68 0 2478 1.0 0.027091 0.027091 100.0 24440 hbb HBB_8782 91.4283 91.4283 91.4283 91.4283 54.7263 54.7263 54.7263 54.7263 277.036 277.036 277.036 277.036 0.0 91.4283 0.0 91.4283 91.4283 54.7263 277.036 0 1 0 1 24440 HBB_8782 91.4283 91.4283 54.7263 54.7263 277.036 277.036 91.4283 54.7263 277.036 0 Linear,1(1) 1.7553097009658813 1.7553097009658813 1.7553097009658813 1.7553097009658813 0.0 1.7553097009658813 91.4283 91.4283 54.7263 54.7263 277.036 277.036 DOWN 0.0 1.0 0.0 GO:0021889 8 olfactory bulb interneuron differentiation 1 1 1 1 1 1 1 1 68 0 2478 1.0 0.027091 0.027091 100.0 282840 atf5 ATF5_8097 97.9563 97.9563 97.9563 97.95629999999998 75.2121 75.2121 75.2121 75.2121 114.804 114.804 114.804 114.804 0.0 97.9563 0.0 97.9563 97.9563 75.2121 114.804 0 1 0 1 282840 ATF5_8097 97.9563 97.9563 75.2121 75.2121 114.804 114.804 97.9563 75.2121 114.804 0 Poly 2,1(1) 2.385996103286743 2.385996103286743 2.385996103286743 2.385996103286743 0.0 2.385996103286743 97.9563 97.9563 75.2121 75.2121 114.804 114.804 DOWN 0.0 1.0 0.0 GO:0021891 8 olfactory bulb interneuron development 1 1 1 1 1 1 1 1 68 0 2478 1.0 0.027091 0.027091 100.0 282840 atf5 ATF5_8097 97.9563 97.9563 97.9563 97.95629999999998 75.2121 75.2121 75.2121 75.2121 114.804 114.804 114.804 114.804 0.0 97.9563 0.0 97.9563 97.9563 75.2121 114.804 0 1 0 1 282840 ATF5_8097 97.9563 97.9563 75.2121 75.2121 114.804 114.804 97.9563 75.2121 114.804 0 Poly 2,1(1) 2.385996103286743 2.385996103286743 2.385996103286743 2.385996103286743 0.0 2.385996103286743 97.9563 97.9563 75.2121 75.2121 114.804 114.804 DOWN 0.0 1.0 0.0 GO:0050790 4 regulation of catalytic activity 528 565 17 17 15 14 13 13 56 552 1926 0.3046 0.79272 0.55946 2.3 24825;84386;24516;85430;361921;116663;498709;114851;58919;24770;287562;25649;29339 tf;slpi;jun;herpud1;ect2;dusp6;cks2;cdkn1a;ccnd1;ccl2;ccl12;apoa2;apcs TF_10003;SLPI_9890;JUN_8938;HERPUD1_8795;ECT2_8523;DUSP6_8506;CKS2_8325;CDKN1A_8271;CCND1_8224;CCL2_8218;CCL12_8217;APOA2_33095;APCS_8057 49.88163076923077 53.893 14.4142 25.116929447698045 53.03510931991218 25.39000983477648 33.04648076923077 37.9512 9.59235 15.068963009631453 34.774978549693785 14.952655751659863 131.84956153846153 94.4701 29.0958 113.91069914987892 156.606759683901 124.49338452854822 51.412;56.5193;57.7663;53.893;14.4142;45.5478;14.4197;54.5478;28.2655;64.0097;25.5289;80.183;101.954 36.6131;39.3315;38.6865;37.9512;9.59235;33.3115;9.6236;38.2987;22.3101;41.1311;13.9582;50.2978;58.4986 86.0232;100.108;109.049;92.6554;30.0753;71.7388;29.0958;94.4701;38.3337;132.851;336.862;197.161;395.621 6 7 6 24825;85430;361921;498709;58919;25649 TF_10003;HERPUD1_8795;ECT2_8523;CKS2_8325;CCND1_8224;APOA2_33095 40.43123333333333 39.83875 26.013420801014746 27.731358333333333 29.4616 16.60650092772155 78.89073333333333 62.17845 64.39805738777115 51.412;53.893;14.4142;14.4197;28.2655;80.183 36.6131;37.9512;9.59235;9.6236;22.3101;50.2978 86.0232;92.6554;30.0753;29.0958;38.3337;197.161 7 84386;24516;116663;114851;24770;287562;29339 SLPI_9890;JUN_8938;DUSP6_8506;CDKN1A_8271;CCL2_8218;CCL12_8217;APCS_8057 57.981971428571434 56.5193 23.06390660734605 37.6023 38.6865 13.109874190980399 177.24284285714288 109.049 131.4791141600553 56.5193;57.7663;45.5478;54.5478;64.0097;25.5289;101.954 39.3315;38.6865;33.3115;38.2987;41.1311;13.9582;58.4986 100.108;109.049;71.7388;94.4701;132.851;336.862;395.621 0 Exp 2,2(0.16);Linear,8(0.62);Poly 2,3(0.24) 1.688930820108555 22.1345853805542 1.5230457782745361 2.2675669193267822 0.23650681256906178 1.5823365449905396 36.2279123898817 63.53534914857985 24.854899165644547 41.23806237281699 69.9270001112825 193.77212296564062 CONFLICT 0.46153846153846156 0.5384615384615384 0.0 GO:0071375 6 cellular response to peptide hormone stimulus 102 109 7 7 6 7 6 6 63 103 2375 0.97384 0.072123 0.072123 5.5 78968;362282;79438;24450;29680;24770 srebf1;pck1;igfals;hmgcs2;cyp11a1;ccl2 SREBF1_32750;PCK1_9439;IGFALS_8880;HMGCS2_8812;CYP11A1_32785;CCL2_8218 37.57396166666667 37.15875 5.51457 26.766071425728807 45.409461586520074 25.094090973701373 25.253941666666673 29.030900000000003 1.34064 18.63827333190112 31.034202218451245 16.264237046961885 75.06081666666667 52.234350000000006 24.5771 52.71046211292089 87.84000770554493 56.91946174963066 4.5 67.18799999999999 11.2357;5.51457;70.3663;30.5985;43.719;64.0097 4.94421;1.34064;46.0459;24.577;33.4848;41.1311 24.5771;39.6721;148.796;40.5656;63.9031;132.851 4 2 4 78968;362282;24450;29680 SREBF1_32750;PCK1_9439;HMGCS2_8812;CYP11A1_32785 22.7669425 20.9171 17.61567405117457 16.086662500000003 14.760605000000002 15.452944127447848 42.179475000000004 40.11885 16.23423348655035 11.2357;5.51457;30.5985;43.719 4.94421;1.34064;24.577;33.4848 24.5771;39.6721;40.5656;63.9031 2 79438;24770 IGFALS_8880;CCL2_8218 67.18799999999999 67.18799999999999 4.49479496529079 43.5885 43.5885 3.475288408175687 140.8235 140.8235 11.274817626019253 70.3663;64.0097 46.0459;41.1311 148.796;132.851 0 Exp 2,3(0.5);Hill,2(0.34);Linear,1(0.17) 2.1333755969437687 13.411335587501526 1.527578592300415 3.3687045574188232 0.7580814585426108 2.0488346815109253 16.156643978771275 58.99127935456205 10.340216945770853 40.16766638756248 32.88366281423272 117.23797051910059 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0044242 5 cellular lipid catabolic process 56 64 4 4 4 4 4 4 65 60 2418 0.97208 0.093104 0.093104 6.25 362282;171142;29740;25649 pck1;ehhadh;eci1;apoa2 PCK1_9439;EHHADH_8534;ECI1_8520;APOA2_33095 55.4060425 56.4393 5.51457 44.36983738831924 70.58093986000121 34.298191219898015 31.819885 37.82055 1.34064 23.37370247383942 41.82430108634261 17.662442816590328 97.282825 76.1491 39.6721 73.30688861020613 137.8524297963108 76.31499554324421 2.5 91.707 5.51457;32.6956;103.231;80.183 1.34064;25.6436;49.9975;50.2978 39.6721;45.0542;107.244;197.161 4 0 4 362282;171142;29740;25649 PCK1_9439;EHHADH_8534;ECI1_8520;APOA2_33095 55.4060425 56.4393 44.36983738831924 31.819885 37.82055 23.37370247383942 97.282825 76.1491 73.30688861020613 5.51457;32.6956;103.231;80.183 1.34064;25.6436;49.9975;50.2978 39.6721;45.0542;107.244;197.161 0 0 Exp 2,1(0.25);Exp 3,1(0.25);Hill,1(0.25);Linear,1(0.25) 1.9196594836603766 7.749824643135071 1.618504285812378 2.3449018001556396 0.30759544535424876 1.8932092785835266 11.923601859447146 98.88848314055285 8.91365657563738 54.72611342436262 25.442074161998008 169.123575838002 UP 1.0 0.0 0.0 GO:0071479 6 cellular response to ionizing radiation 24 24 2 2 2 2 2 2 67 22 2456 0.97437 0.1364 0.1364 8.33 361921;114851 ect2;cdkn1a ECT2_8523;CDKN1A_8271 34.481 34.481 14.4142 28.378740713428417 42.21606467241099 26.185692152533203 23.945524999999996 23.945524999999996 9.59235 20.29845474811445 29.478182767029747 18.729833454334305 62.2727 62.2727 30.0753 45.5339997531515 74.68369583807511 42.015229359537756 0.5 34.481 14.4142;54.5478 9.59235;38.2987 30.0753;94.4701 1 1 1 361921 ECT2_8523 14.4142 14.4142 9.59235 9.59235 30.0753 30.0753 14.4142 9.59235 30.0753 1 114851 CDKN1A_8271 54.5478 54.5478 38.2987 38.2987 94.4701 94.4701 54.5478 38.2987 94.4701 0 Linear,1(0.5);Poly 2,1(0.5) 1.7211942040550916 3.4443163871765137 1.6645443439483643 1.7797720432281494 0.08147828754126034 1.7221581935882568 -4.8499279999999985 73.811928 -4.186698 52.07774799999999 -0.8342039999999997 125.379604 CONFLICT 0.5 0.5 0.0 GO:0006954 5 inflammatory response 129 140 7 7 7 6 6 6 63 134 2344 0.91845 0.17564 0.27387 4.29 29142;24825;360918;24770;287562;25649 vnn1;tf;pf4;ccl2;ccl12;apoa2 VNN1_10157;TF_10003;PF4_32963;CCL2_8218;CCL12_8217;APOA2_33095 57.970333333333336 57.71084999999999 20.8684 32.53145831404836 53.97454761134694 29.792027615990683 35.49528333333333 38.8721 13.9582 16.677039354683632 33.38427021090223 17.730680962836782 148.21993333333333 121.363 26.5474 108.03724760652999 201.17354786065633 116.07208684556775 20.8684;51.412;105.82;64.0097;25.5289;80.183 17.1194;36.6131;53.8521;41.1311;13.9582;50.2978 26.5474;86.0232;109.875;132.851;336.862;197.161 3 3 3 29142;24825;25649 VNN1_10157;TF_10003;APOA2_33095 50.821133333333336 51.412 29.66171414219572 34.67676666666667 36.6131 16.6737397341848 103.24386666666668 86.0232 86.6005984192565 20.8684;51.412;80.183 17.1194;36.6131;50.2978 26.5474;86.0232;197.161 3 360918;24770;287562 PF4_32963;CCL2_8218;CCL12_8217 65.11953333333334 64.0097 40.157053954732945 36.3138 41.1311 20.378557327985718 193.196 132.851 124.94764427951418 105.82;64.0097;25.5289 53.8521;41.1311;13.9582 109.875;132.851;336.862 0 Exp 2,2(0.34);Exp 3,1(0.17);Linear,2(0.34);Poly 2,1(0.17) 1.8922064920903134 11.549672722816467 1.5314651727676392 2.642244338989258 0.4045581964288114 1.9055543541908264 31.939745337040264 84.00092132962641 22.15087263249894 48.83969403416773 61.772130915430935 234.6677357512358 CONFLICT 0.5 0.5 0.0 GO:0001701 7 in utero embryonic development 63 65 2 2 2 2 2 2 67 63 2415 0.74292 0.53151 0.69543 3.08 366960;360504 maff;hba-a2 MAFF_9172;HBA2_32600 79.73775 79.73775 58.0695 30.64353302289079 68.38205756381704 26.0983258986976 62.3864 62.3864 40.1293 31.476292679094215 50.722108600308374 26.807566340609146 110.343 110.343 104.733 7.9337380849131725 107.40296402261436 6.756965066015715 58.0695;101.406 40.1293;84.6435 104.733;115.953 2 0 2 366960;360504 MAFF_9172;HBA2_32600 79.73775 79.73775 30.64353302289079 62.3864 62.3864 31.476292679094215 110.343 110.343 7.9337380849131725 58.0695;101.406 40.1293;84.6435 104.733;115.953 0 0 Linear,1(0.5);Poly 2,1(0.5) 1.7997299760469319 3.5997226238250732 1.778118371963501 1.8216042518615723 0.03074916056178998 1.7998613119125366 37.26798 122.20752000000002 18.762484000000008 106.01031599999999 99.34740000000001 121.3386 UP 1.0 0.0 0.0 GO:0032269 7 negative regulation of cellular protein metabolic process 274 292 8 8 7 7 6 6 63 286 2192 0.30659 0.8207 0.56826 2.05 84386;24516;85430;116663;299691;114851 slpi;jun;herpud1;dusp6;cry1;cdkn1a SLPI_9890;JUN_8938;HERPUD1_8795;DUSP6_8506;CRY1_8386;CDKN1A_8271 50.9215 54.2204 37.2548 7.947601605515967 50.08653439859698 8.45473893004925 34.909866666666666 38.12495 21.8798 6.73624693450788 34.18411524820967 7.327339358886346 90.30773333333333 93.56275 71.7388 14.741774823903235 89.04462554927659 14.858001775913872 56.5193;57.7663;53.893;45.5478;37.2548;54.5478 39.3315;38.6865;37.9512;33.3115;21.8798;38.2987 100.108;109.049;92.6554;71.7388;73.8251;94.4701 1 5 1 85430 HERPUD1_8795 53.893 53.893 37.9512 37.9512 92.6554 92.6554 53.893 37.9512 92.6554 5 84386;24516;116663;299691;114851 SLPI_9890;JUN_8938;DUSP6_8506;CRY1_8386;CDKN1A_8271 50.327200000000005 54.5478 8.735360348892293 34.3016 38.2987 7.34481898483549 89.8382 94.4701 16.431568536357034 56.5193;57.7663;45.5478;37.2548;54.5478 39.3315;38.6865;33.3115;21.8798;38.2987 100.108;109.049;71.7388;73.8251;94.4701 0 Exp 2,2(0.34);Linear,4(0.67) 1.6171221305221821 9.726909160614014 1.5230457782745361 1.8622472286224365 0.12872622071781992 1.5749927163124084 44.5620942532701 57.28090574672991 29.519746528162326 40.299986805171 78.5118567676204 102.10360989904629 DOWN 0.16666666666666666 0.8333333333333334 0.0 GO:0032868 6 response to insulin 96 102 6 6 5 6 5 5 64 97 2381 0.94447 0.14001 0.19732 4.9 78968;362282;24450;299691;24770 srebf1;pck1;hmgcs2;cry1;ccl2 SREBF1_32750;PCK1_9439;HMGCS2_8812;CRY1_8386;CCL2_8218 29.722654 30.5985 5.51457 23.242744309441598 34.33869580521328 16.91189991897868 18.77455 21.8798 1.34064 16.11168717011971 22.31269488672986 11.488174069851848 62.29818 40.5656 24.5771 43.352320297268975 65.00203765402844 35.625993984696535 11.2357;5.51457;30.5985;37.2548;64.0097 4.94421;1.34064;24.577;21.8798;41.1311 24.5771;39.6721;40.5656;73.8251;132.851 3 2 3 78968;362282;24450 SREBF1_32750;PCK1_9439;HMGCS2_8812 15.782923333333335 11.2357 13.145676707329802 10.287283333333335 4.94421 12.50573592382445 34.93826666666667 39.6721 8.98414807220658 11.2357;5.51457;30.5985 4.94421;1.34064;24.577 24.5771;39.6721;40.5656 2 299691;24770 CRY1_8386;CCL2_8218 50.63225 50.63225 18.918571219967966 31.505450000000003 31.505450000000003 13.612724776656584 103.33805000000001 103.33805000000001 41.737614155639015 37.2548;64.0097 21.8798;41.1311 73.8251;132.851 0 Exp 2,3(0.6);Hill,2(0.4) 2.3085680283017576 11.993236660957336 1.559963583946228 3.3687045574188232 0.7323740500312208 2.3449018001556396 9.34949034625333 50.095817653746664 4.65203352411724 32.89706647588277 24.29819581452137 100.29816418547864 UP 0.6 0.4 0.0 GO:0042594 4 response to starvation 75 79 6 6 6 6 6 6 63 73 2405 0.99516 0.018608 0.018608 7.59 78968;362282;24516;24450;114851;25612 srebf1;pck1;jun;hmgcs2;cdkn1a;asns SREBF1_32750;PCK1_9439;JUN_8938;HMGCS2_8812;CDKN1A_8271;ASNS_8091 40.887845 42.57315 5.51457 30.70109929214506 50.01524846950235 25.06250956470749 26.924358333333334 31.437849999999997 1.34064 20.628979964667586 33.980641391521026 15.775336445447412 88.80364999999999 67.51785000000001 24.5771 74.4554821154964 100.79894227556679 70.08927489835635 2.5 42.57315 11.2357;5.51457;57.7663;30.5985;54.5478;85.6642 4.94421;1.34064;38.6865;24.577;38.2987;53.6991 24.5771;39.6721;109.049;40.5656;94.4701;224.488 4 2 4 78968;362282;24450;25612 SREBF1_32750;PCK1_9439;HMGCS2_8812;ASNS_8091 33.2532425 20.9171 36.552073601049756 21.1402375 14.760605000000002 23.987679002063224 82.3257 40.11885 95.05832575883784 11.2357;5.51457;30.5985;85.6642 4.94421;1.34064;24.577;53.6991 24.5771;39.6721;40.5656;224.488 2 24516;114851 JUN_8938;CDKN1A_8271 56.15705 56.15705 2.2758231752491507 38.492599999999996 38.492599999999996 0.27421600974518423 101.75955 101.75955 10.308839052240765 57.7663;54.5478 38.6865;38.2987 109.049;94.4701 0 Exp 2,3(0.5);Hill,2(0.34);Linear,1(0.17) 2.122093735547314 13.354559302330017 1.5230457782745361 3.3687045574188232 0.7648463986803091 2.004723072052002 16.321849249296108 65.45384075070389 10.417736556339236 43.430980110327425 29.226856352944324 148.3804436470557 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0044249 4 cellular biosynthetic process 372 415 18 17 16 16 14 14 55 401 2077 0.85847 0.22308 0.40695 3.37 78968;25044;83792;287877;362282;114519;24516;24450;81660;24306;29680;25612;25649;81639 srebf1;sds;scd2;pycr1;pck1;nfil3;jun;hmgcs2;gatm;cyp4a2;cyp11a1;asns;apoa2;alox15 SREBF1_32750;SDS_9798;SCD_9786;PYCR1_9631;PCK1_9439;NFIL3_9304;JUN_8938;HMGCS2_8812;GATM_32792;CYP4A2_8425;CYP11A1_32785;ASNS_8091;APOA2_33095;ALOX15_8036 53.84716214285714 56.23925 5.51457 29.03279409403581 60.040666418663136 25.9367495391911 37.42249642857143 38.53605 1.34064 20.949197643224583 41.973823740062734 18.58855869725779 104.19129285714287 97.26055 24.5771 66.0055794821394 114.36923021875508 64.19296665946942 11.2357;64.7394;83.9984;54.7122;5.51457;33.1149;57.7663;30.5985;37.423;59.5671;43.719;85.6642;80.183;105.624 4.94421;43.4259;54.1928;38.3856;1.34064;25.603;38.6865;24.577;28.03;43.4174;33.4848;53.6991;50.2978;83.8302 24.5771;126.828;206.18;94.9303;39.6721;46.6318;109.049;40.5656;55.6613;99.5908;63.9031;224.488;197.161;129.44 10 4 10 78968;83792;287877;362282;24450;24306;29680;25612;25649;81639 SREBF1_32750;SCD_9786;PYCR1_9631;PCK1_9439;HMGCS2_8812;CYP4A2_8425;CYP11A1_32785;ASNS_8091;APOA2_33095;ALOX15_8036 56.081667 57.13965 33.45682180145031 38.81695499999999 40.9015 24.54087808150912 112.05080000000001 97.26055 74.39801596601887 11.2357;83.9984;54.7122;5.51457;30.5985;59.5671;43.719;85.6642;80.183;105.624 4.94421;54.1928;38.3856;1.34064;24.577;43.4174;33.4848;53.6991;50.2978;83.8302 24.5771;206.18;94.9303;39.6721;40.5656;99.5908;63.9031;224.488;197.161;129.44 4 25044;114519;24516;81660 SDS_9798;NFIL3_9304;JUN_8938;GATM_32792 48.26090000000001 47.59465 15.37048019006994 33.936350000000004 33.35825 8.503826134354647 84.54252500000001 82.35515000000001 39.41225249600895 64.7394;33.1149;57.7663;37.423 43.4259;25.603;38.6865;28.03 126.828;46.6318;109.049;55.6613 0 Exp 2,7(0.5);Hill,2(0.15);Linear,4(0.29);Poly 2,1(0.08) 2.0470179350854383 29.49149465560913 1.5230457782745361 3.3687045574188232 0.5542544556553911 1.916516363620758 38.638854555568116 69.05546973014617 26.448635613345246 48.396357243797624 69.61545589187307 138.76712982241264 UP 0.7142857142857143 0.2857142857142857 0.0 GO:0010648 6 negative regulation of cell communication 320 334 12 12 10 11 9 9 60 325 2153 0.58097 0.56222 1.0 2.69 29142;78968;360918;85430;24367;116663;299691;29657;25649 vnn1;srebf1;pf4;herpud1;fgg;dusp6;cry1;arntl;apoa2 VNN1_10157;SREBF1_32750;PF4_32963;HERPUD1_8795;FGG_8639;DUSP6_8506;CRY1_8386;ARNTL_8086;APOA2_33095 54.02253333333333 45.5478 11.2357 32.46833055498081 52.63735414973213 25.70367055658601 33.09084555555555 33.3115 4.94421 16.92762193350495 33.50658719125254 14.179795292971512 109.66235555555555 73.8251 24.5771 96.41961186877532 107.82206139386662 78.61878701024314 20.8684;11.2357;105.82;53.893;93.1824;45.5478;37.2548;38.2177;80.183 17.1194;4.94421;53.8521;37.9512;51.338;33.3115;21.8798;27.1236;50.2978 26.5474;24.5771;109.875;92.6554;327.378;71.7388;73.8251;63.2034;197.161 4 5 4 29142;78968;85430;25649 VNN1_10157;SREBF1_32750;HERPUD1_8795;APOA2_33095 41.545025 37.380700000000004 31.578176018929593 27.5781525 27.5353 20.37533929297109 85.235225 59.6014 81.04753140005253 20.8684;11.2357;53.893;80.183 17.1194;4.94421;37.9512;50.2978 26.5474;24.5771;92.6554;197.161 5 360918;24367;116663;299691;29657 PF4_32963;FGG_8639;DUSP6_8506;CRY1_8386;ARNTL_8086 64.00453999999999 45.5478 32.86731342790281 37.501 33.3115 14.388235390936583 129.20406 73.8251 112.21819760358832 105.82;93.1824;45.5478;37.2548;38.2177 53.8521;51.338;33.3115;21.8798;27.1236 109.875;327.378;71.7388;73.8251;63.2034 0 Exp 2,3(0.34);Exp 3,1(0.12);Hill,1(0.12);Linear,3(0.34);Power,1(0.12) 2.186275803250269 21.073755621910095 1.5270863771438599 4.897102355957031 1.0580288548708248 1.9088982343673706 32.809890704079216 75.23517596258745 22.03146589233232 44.150225218778786 46.668209134622366 172.65650197648876 CONFLICT 0.4444444444444444 0.5555555555555556 0.0 GO:0120161 4 regulation of cold-induced thermogenesis 48 55 2 2 2 2 2 2 67 53 2425 0.81464 0.4428 0.65998 3.64 81660;29657 gatm;arntl GATM_32792;ARNTL_8086 37.820350000000005 37.820350000000005 37.423 0.5619377590086565 37.754589778657554 0.5541888049915294 27.5768 27.5768 27.1236 0.6409215864677303 27.651803227160936 0.6320834690380788 59.43235 59.43235 55.6613 5.333070054387029 58.80825264831144 5.259528609697818 37.423;38.2177 28.03;27.1236 55.6613;63.2034 0 2 0 2 81660;29657 GATM_32792;ARNTL_8086 37.820350000000005 37.820350000000005 0.5619377590086565 27.5768 27.5768 0.6409215864677303 59.43235 59.43235 5.333070054387029 37.423;38.2177 28.03;27.1236 55.6613;63.2034 0 Exp 2,1(0.5);Power,1(0.5) 3.269869005972765 7.0804431438446045 2.1833407878875732 4.897102355957031 1.9189192073053523 3.5402215719223022 37.04154400000001 38.599156 26.688527999999998 28.465072 52.04109199999999 66.82360800000001 DOWN 0.0 1.0 0.0 GO:0071901 9 negative regulation of protein serine/threonine kinase activity 40 43 2 2 2 2 2 2 67 41 2437 0.89103 0.32589 0.32589 4.65 116663;114851 dusp6;cdkn1a DUSP6_8506;CDKN1A_8271 50.0478 50.0478 45.5478 6.363961030678928 50.47254637215873 6.3355489926821935 35.805099999999996 35.805099999999996 33.3115 3.526482939133565 36.04046612302556 3.510738881811531 83.10445 83.10445 71.7388 16.073456375185824 84.17723191216129 16.001696090817394 45.5478;54.5478 33.3115;38.2987 71.7388;94.4701 0 2 0 2 116663;114851 DUSP6_8506;CDKN1A_8271 50.0478 50.0478 6.363961030678928 35.805099999999996 35.805099999999996 3.526482939133565 83.10445 83.10445 16.073456375185824 45.5478;54.5478 33.3115;38.2987 71.7388;94.4701 0 Linear,2(1) 1.6153702638121643 3.2321932315826416 1.5676488876342773 1.6645443439483643 0.06851543422585574 1.6160966157913208 41.2278 58.8678 30.917644000000003 40.69255599999999 60.827776 105.381124 DOWN 0.0 1.0 0.0 GO:0019637 4 organophosphate metabolic process 156 173 5 5 5 5 5 5 64 168 2310 0.67373 0.50904 0.80783 2.89 29692;362282;24450;25649;81639 pla2g2a;pck1;hmgcs2;apoa2;alox15 PLA2G2A_32641;PCK1_9439;HMGCS2_8812;APOA2_33095;ALOX15_8036 44.384014000000235 30.5985 1.16694E-12 46.64417985068934 62.36011542976217 42.07854286107295 32.00912800000024 24.577 1.16694E-12 35.49745055946837 44.862905482727854 31.909881856487342 81.36774000000023 40.5656 1.16694E-12 80.22323756124501 112.57567942906114 81.95694014192681 1.16694E-12;5.51457;30.5985;80.183;105.624 1.16694E-12;1.34064;24.577;50.2978;83.8302 1.16694E-12;39.6721;40.5656;197.161;129.44 4 1 4 362282;24450;25649;81639 PCK1_9439;HMGCS2_8812;APOA2_33095;ALOX15_8036 55.4800175 55.390750000000004 45.6080847450452 40.01141 37.437400000000004 35.40030904166988 101.709675 85.00280000000001 76.304619756053 5.51457;30.5985;80.183;105.624 1.34064;24.577;50.2978;83.8302 39.6721;40.5656;197.161;129.44 1 29692 PLA2G2A_32641 1.16694E-12 1.16694E-12 1.16694E-12 1.16694E-12 1.16694E-12 1.16694E-12 1.16694E-12 1.16694E-12 1.16694E-12 0 Exp 2,1(0.2);Hill,2(0.4);Linear,1(0.2);Poly 2,1(0.2) 2.2070782392705506 11.364689230918884 1.6914535760879517 3.3687045574188232 0.6549801297346943 1.988358974456787 3.498587694860227 85.26944030514025 0.8942407082678123 63.12401529173265 11.048971875673388 151.68650812432708 UP 0.8 0.2 0.0 GO:2000026 5 regulation of multicellular organismal development 487 514 23 22 20 19 17 17 52 497 1981 0.8608 0.21348 0.36142 3.31 29142;24825;360918;338475;366960;290350;24516;361921;116663;170568;84032;58919;24770;282840;289054;29657;29339 vnn1;tf;pf4;nrep;maff;loxl2;jun;ect2;dusp6;dmbt1;col3a1;ccnd1;ccl2;atf5;aspm;arntl;apcs VNN1_10157;TF_10003;PF4_32963;NREP_9364;MAFF_9172;LOXL2_9150;JUN_8938;ECT2_8523;DUSP6_8506;DMBT1_32993;COL3A1_8354;CCND1_8224;CCL2_8218;ATF5_8097;ASPM_8092;ARNTL_8086;APCS_8057 51.56177058823529 51.412 10.3235 29.568783839692433 54.703933809541574 29.56258750071624 34.40663823529412 36.6131 7.4611 18.01457747979335 37.11146252999615 19.112874515486006 102.92721176470589 104.733 16.8623 86.17420249745486 117.28489347234138 101.64168857551142 20.8684;51.412;105.82;36.861;58.0695;65.4434;57.7663;14.4142;45.5478;21.7434;57.8774;28.2655;64.0097;97.9563;10.3235;38.2177;101.954 17.1194;36.6131;53.8521;28.0333;40.1293;43.7615;38.6865;9.59235;33.3115;12.6557;39.4215;22.3101;41.1311;75.2121;7.4611;27.1236;58.4986 26.5474;86.0232;109.875;53.5645;104.733;129.393;109.049;30.0753;71.7388;160.485;106.603;38.3337;132.851;114.804;16.8623;63.2034;395.621 7 10 7 29142;24825;366960;361921;170568;58919;289054 VNN1_10157;TF_10003;MAFF_9172;ECT2_8523;DMBT1_32993;CCND1_8224;ASPM_8092 29.299500000000002 21.7434 18.382888505165155 20.840149999999998 17.1194 12.970217156592511 66.1514142857143 38.3337 53.002292406505994 20.8684;51.412;58.0695;14.4142;21.7434;28.2655;10.3235 17.1194;36.6131;40.1293;9.59235;12.6557;22.3101;7.4611 26.5474;86.0232;104.733;30.0753;160.485;38.3337;16.8623 10 360918;338475;290350;24516;116663;84032;24770;282840;29657;29339 PF4_32963;NREP_9364;LOXL2_9150;JUN_8938;DUSP6_8506;COL3A1_8354;CCL2_8218;ATF5_8097;ARNTL_8086;APCS_8057 67.14536000000001 60.94355 25.956546323987943 43.903180000000006 40.276300000000006 14.880451582589071 128.67027 109.462 97.67643146891854 105.82;36.861;65.4434;57.7663;45.5478;57.8774;64.0097;97.9563;38.2177;101.954 53.8521;28.0333;43.7615;38.6865;33.3115;39.4215;41.1311;75.2121;27.1236;58.4986 109.875;53.5645;129.393;109.049;71.7388;106.603;132.851;114.804;63.2034;395.621 0 Exp 2,4(0.24);Exp 3,1(0.06);Linear,7(0.42);Poly 2,4(0.24);Power,1(0.06) 1.9043359876645294 34.03348112106323 1.5230457782745361 4.897102355957031 0.8143253223342841 1.7373461723327637 37.5056629867922 65.61787818967838 25.843051689992933 42.97022478059529 61.962596197839495 143.89182733157222 CONFLICT 0.4117647058823529 0.5882352941176471 0.0 GO:0043068 7 positive regulation of programmed cell death 198 213 9 9 8 6 6 6 63 207 2271 0.64562 0.52401 0.82637 2.82 360243;24516;361921;116663;114851;24770 top2a;jun;ect2;dusp6;cdkn1a;ccl2 TOP2A_10059;JUN_8938;ECT2_8523;DUSP6_8506;CDKN1A_8271;CCL2_8218 41.68748333333334 50.0478 13.8391 22.165125444753674 46.22546831223773 17.973961693830255 28.389398333333332 35.805099999999996 9.31624 14.885677702329067 31.975869547951284 12.206681501574447 77.64656666666667 83.10445 27.6952 42.684282127859035 82.97814886561359 34.26059581878493 13.8391;57.7663;14.4142;45.5478;54.5478;64.0097 9.31624;38.6865;9.59235;33.3115;38.2987;41.1311 27.6952;109.049;30.0753;71.7388;94.4701;132.851 2 4 2 360243;361921 TOP2A_10059;ECT2_8523 14.12665 14.12665 0.40665710986038317 9.454295 9.454295 0.19523925335338116 28.88525 28.88525 1.6829848499020597 13.8391;14.4142 9.31624;9.59235 27.6952;30.0753 4 24516;116663;114851;24770 JUN_8938;DUSP6_8506;CDKN1A_8271;CCL2_8218 55.4679 56.15705 7.691986258871464 37.85695 38.492599999999996 3.279454740755989 102.027225 101.75955 25.650921079287457 57.7663;45.5478;54.5478;64.0097 38.6865;33.3115;38.2987;41.1311 109.049;71.7388;94.4701;132.851 0 Exp 2,2(0.34);Linear,2(0.34);Poly 2,2(0.34) 1.6597170225751199 9.989359974861145 1.5230457782745361 1.8943853378295898 0.14591181124933905 1.6160966157913208 23.951689174687328 59.423277491979334 16.478375483564434 40.30042118310223 43.49202765825035 111.801105675083 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0050793 4 regulation of developmental process 584 616 26 25 22 22 19 19 50 597 1881 0.791 0.29696 0.47977 3.08 29142;24825;360918;338475;366960;290350;24516;361921;116663;170568;84032;114851;58919;24770;287562;282840;289054;29657;29339 vnn1;tf;pf4;nrep;maff;loxl2;jun;ect2;dusp6;dmbt1;col3a1;cdkn1a;ccnd1;ccl2;ccl12;atf5;aspm;arntl;apcs VNN1_10157;TF_10003;PF4_32963;NREP_9364;MAFF_9172;LOXL2_9150;JUN_8938;ECT2_8523;DUSP6_8506;DMBT1_32993;COL3A1_8354;CDKN1A_8271;CCND1_8224;CCL2_8218;CCL12_8217;ATF5_8097;ASPM_8092;ARNTL_8086;APCS_8057 50.34877894736841 51.412 10.3235 28.526477701671787 51.8507947635478 28.06242634937344 33.53525 36.6131 7.4611 17.656065636638253 34.960607007306685 18.615222991171766 114.79445789473685 104.733 16.8623 97.45001556916424 136.683476370002 113.93277686337241 20.8684;51.412;105.82;36.861;58.0695;65.4434;57.7663;14.4142;45.5478;21.7434;57.8774;54.5478;28.2655;64.0097;25.5289;97.9563;10.3235;38.2177;101.954 17.1194;36.6131;53.8521;28.0333;40.1293;43.7615;38.6865;9.59235;33.3115;12.6557;39.4215;38.2987;22.3101;41.1311;13.9582;75.2121;7.4611;27.1236;58.4986 26.5474;86.0232;109.875;53.5645;104.733;129.393;109.049;30.0753;71.7388;160.485;106.603;94.4701;38.3337;132.851;336.862;114.804;16.8623;63.2034;395.621 7 12 7 29142;24825;366960;361921;170568;58919;289054 VNN1_10157;TF_10003;MAFF_9172;ECT2_8523;DMBT1_32993;CCND1_8224;ASPM_8092 29.299500000000002 21.7434 18.382888505165155 20.840149999999998 17.1194 12.970217156592511 66.1514142857143 38.3337 53.002292406505994 20.8684;51.412;58.0695;14.4142;21.7434;28.2655;10.3235 17.1194;36.6131;40.1293;9.59235;12.6557;22.3101;7.4611 26.5474;86.0232;104.733;30.0753;160.485;38.3337;16.8623 12 360918;338475;290350;24516;116663;84032;114851;24770;287562;282840;29657;29339 PF4_32963;NREP_9364;LOXL2_9150;JUN_8938;DUSP6_8506;COL3A1_8354;CDKN1A_8271;CCL2_8218;CCL12_8217;ATF5_8097;ARNTL_8086;APCS_8057 62.62752499999999 57.82185 26.473621412236184 40.94072500000001 39.054 15.99900252988091 143.16956666666667 109.462 107.81164560262528 105.82;36.861;65.4434;57.7663;45.5478;57.8774;54.5478;64.0097;25.5289;97.9563;38.2177;101.954 53.8521;28.0333;43.7615;38.6865;33.3115;39.4215;38.2987;41.1311;13.9582;75.2121;27.1236;58.4986 109.875;53.5645;129.393;109.049;71.7388;106.603;94.4701;132.851;336.862;114.804;63.2034;395.621 0 Exp 2,4(0.22);Exp 3,1(0.06);Linear,8(0.43);Poly 2,5(0.27);Power,1(0.06) 1.8693322027189003 37.229490637779236 1.5230457782745361 4.897102355957031 0.7785630085607188 1.6645443439483643 37.521710226692775 63.17584766804406 25.596114659619502 41.47438534038049 70.97558689324178 158.6133288962319 DOWN 0.3684210526315789 0.631578947368421 0.0 GO:0045944 9 positive regulation of transcription by RNA polymerase II 241 260 14 14 12 13 11 11 58 249 2229 0.95658 0.087177 0.10913 4.23 360243;78968;360918;362282;316351;366960;24516;24309;306575;282840;29657 top2a;srebf1;pf4;pck1;npas2;maff;jun;dbp;ckap2;atf5;arntl TOP2A_10059;SREBF1_32750;PF4_32963;PCK1_9439;NPAS2_9350;MAFF_9172;JUN_8938;DBP_8439;CKAP2_8324;ATF5_8097;ARNTL_8086 46.31521545454546 50.6952 5.51457 34.38431191345011 56.63482586733849 29.96462834014487 30.496030000000005 35.795 1.34064 22.984392313600548 39.08402261514443 22.210154044110997 70.3596 63.2034 21.3803 38.060143322798986 84.81159600217634 32.74031282602714 13.8391;11.2357;105.82;5.51457;58.2312;58.0695;57.7663;50.6952;12.1218;97.9563;38.2177 9.31624;4.94421;53.8521;1.34064;35.795;40.1293;38.6865;40.5862;8.47044;75.2121;27.1236 27.6952;24.5771;109.875;39.6721;99.4319;104.733;109.049;59.5346;21.3803;114.804;63.2034 5 6 5 360243;78968;362282;366960;306575 TOP2A_10059;SREBF1_32750;PCK1_9439;MAFF_9172;CKAP2_8324 20.156134 12.1218 21.42328348984534 12.840166 8.47044 15.578788573065623 43.611540000000005 27.6952 34.861224437374545 13.8391;11.2357;5.51457;58.0695;12.1218 9.31624;4.94421;1.34064;40.1293;8.47044 27.6952;24.5771;39.6721;104.733;21.3803 6 360918;316351;24516;24309;282840;29657 PF4_32963;NPAS2_9350;JUN_8938;DBP_8439;ATF5_8097;ARNTL_8086 68.11445 57.99875 27.25528676178257 45.20925 39.63635 17.05583514281843 92.64965 104.24045000000001 24.76349602780273 105.82;58.2312;57.7663;50.6952;97.9563;38.2177 53.8521;35.795;38.6865;40.5862;75.2121;27.1236 109.875;99.4319;109.049;59.5346;114.804;63.2034 0 Exp 2,1(0.1);Exp 3,1(0.1);Hill,2(0.19);Linear,1(0.1);Poly 2,4(0.37);Power,2(0.19) 2.6524495322457278 32.30639898777008 1.5230457782745361 5.737884044647217 1.4832008572829076 2.3449018001556396 25.995385624430554 66.63504528466035 16.913122139678023 44.07893786032197 47.86749262336416 92.85170737663584 CONFLICT 0.45454545454545453 0.5454545454545454 0.0 GO:0097435 5 supramolecular fiber organization 101 107 6 6 6 6 6 6 63 101 2377 0.9761 0.067116 0.067116 5.61 24825;24587;314654;290350;303575;84032 tf;nefh;myo1f;loxl2;kif18b;col3a1 TF_10003;NEFH_33218;MYO1F_32715;LOXL2_9150;KIF18B_32882;COL3A1_8354 58.2809 61.660399999999996 3.6768 30.518656119495166 62.993056809165395 27.698980518695848 36.912456666666664 39.4238 1.12034 19.63305525314047 38.423706524785885 17.203664878952097 118.10268333333333 108.655 11.7489 82.440063699937 143.0745312780394 91.78367645428055 4.5 85.6379 51.412;79.3182;91.9576;65.4434;3.6768;57.8774 36.6131;39.4261;61.1322;43.7615;1.12034;39.4215 86.0232;264.141;110.707;129.393;11.7489;106.603 3 3 3 24825;314654;303575 TF_10003;MYO1F_32715;KIF18B_32882 49.01546666666667 51.412 44.189166558935376 32.95521333333333 36.6131 30.172685268542697 69.49303333333334 86.0232 51.508360451710466 51.412;91.9576;3.6768 36.6131;61.1322;1.12034 86.0232;110.707;11.7489 3 24587;290350;84032 NEFH_33218;LOXL2_9150;COL3A1_8354 67.54633333333334 65.4434 10.873992947088594 40.8697 39.4261 2.5043733188164605 166.71233333333333 129.393 85.14167511467774 79.3182;65.4434;57.8774 39.4261;43.7615;39.4215 264.141;129.393;106.603 0 Exp 2,2(0.34);Exp 4,1(0.17);Linear,2(0.34);Poly 2,1(0.17) 1.7528716797474466 10.554161190986633 1.5863633155822754 2.0048909187316895 0.16225517265744457 1.7522252202033997 33.860889191444706 82.70091080855528 21.202740629059427 52.6221727042739 52.13689379372009 184.0684728729466 CONFLICT 0.5 0.5 0.0 GO:0009896 6 positive regulation of catabolic process 120 128 3 3 2 3 2 2 67 126 2352 0.31606 0.87099 0.5803 1.56 85430;25649 herpud1;apoa2 HERPUD1_8795;APOA2_33095 67.03800000000001 67.03800000000001 53.893 18.58983727739426 72.82483429513603 16.691529219375756 44.1245 44.1245 37.9512 8.73036458459786 46.8421769991756 7.838860200074 144.9082 144.9082 92.6554 73.89661843196888 167.91149365210222 66.35063811290979 53.893;80.183 37.9512;50.2978 92.6554;197.161 2 0 2 85430;25649 HERPUD1_8795;APOA2_33095 67.03800000000001 67.03800000000001 18.58983727739426 44.1245 44.1245 8.73036458459786 144.9082 144.9082 73.89661843196888 53.893;80.183 37.9512;50.2978 92.6554;197.161 0 0 Linear,2(1) 1.735021629725513 3.4983566999435425 1.5270863771438599 1.9712703227996826 0.3140854800674292 1.7491783499717712 41.27380000000001 92.80220000000001 32.024831999999996 56.224168 42.492712 247.323688 UP 1.0 0.0 0.0 GO:1901701 5 cellular response to oxygen-containing compound 359 378 16 15 14 13 12 12 57 366 2112 0.78565 0.32165 0.49589 3.17 24825;78968;360918;362282;24587;24516;79438;24450;361921;29680;84032;24770 tf;srebf1;pf4;pck1;nefh;jun;igfals;hmgcs2;ect2;cyp11a1;col3a1;ccl2 TF_10003;SREBF1_32750;PF4_32963;PCK1_9439;NEFH_33218;JUN_8938;IGFALS_8880;HMGCS2_8812;ECT2_8523;CYP11A1_32785;COL3A1_8354;CCL2_8218 49.337655833333336 54.589150000000004 5.51457 29.953643086356998 53.60810240619614 26.36084305906767 30.759608333333336 37.6498 1.34064 16.915167412724237 33.337101723825526 14.078518436852075 96.34428333333335 96.31309999999999 24.5771 67.22651818831116 116.76045496530692 81.2233645228323 51.412;11.2357;105.82;5.51457;79.3182;57.7663;70.3663;30.5985;14.4142;43.719;57.8774;64.0097 36.6131;4.94421;53.8521;1.34064;39.4261;38.6865;46.0459;24.577;9.59235;33.4848;39.4215;41.1311 86.0232;24.5771;109.875;39.6721;264.141;109.049;148.796;40.5656;30.0753;63.9031;106.603;132.851 6 6 6 24825;78968;362282;24450;361921;29680 TF_10003;SREBF1_32750;PCK1_9439;HMGCS2_8812;ECT2_8523;CYP11A1_32785 26.148995 22.50635 18.722253435976935 18.425349999999998 17.084675 15.146447917391063 47.46940000000001 40.11885 23.201441532628944 51.412;11.2357;5.51457;30.5985;14.4142;43.719 36.6131;4.94421;1.34064;24.577;9.59235;33.4848 86.0232;24.5771;39.6721;40.5656;30.0753;63.9031 6 360918;24587;24516;79438;84032;24770 PF4_32963;NEFH_33218;JUN_8938;IGFALS_8880;COL3A1_8354;CCL2_8218 72.52631666666666 67.18799999999999 18.244156938967276 43.09386666666666 40.2786 5.910502659390918 145.21916666666667 121.363 60.59185940179312 105.82;79.3182;57.7663;70.3663;57.8774;64.0097 53.8521;39.4261;38.6865;46.0459;39.4215;41.1311 109.875;264.141;109.049;148.796;106.603;132.851 0 Exp 2,6(0.5);Exp 3,1(0.09);Hill,2(0.17);Linear,2(0.17);Poly 2,1(0.09) 1.928586032692301 23.915464282035828 1.5230457782745361 3.3687045574188232 0.5822566322201718 1.7734381556510925 32.38978681219751 66.28552485446917 21.18895140339189 40.33026526327478 58.30729992808466 134.381266738582 CONFLICT 0.5 0.5 0.0 GO:0045787 6 positive regulation of cell cycle 111 119 5 5 5 5 5 5 64 114 2364 0.89968 0.21816 0.25333 4.2 361921;498709;114851;58919;25612 ect2;cks2;cdkn1a;ccnd1;asns ECT2_8523;CKS2_8325;CDKN1A_8271;CCND1_8224;ASNS_8091 39.46228 28.2655 14.4142 30.58633409084848 44.66653493269564 28.312237196585134 26.704769999999996 22.3101 9.59235 19.15089734338838 30.57417176688394 17.50413148835059 83.29258 38.3337 29.0958 83.44422437495001 90.69601462182281 79.15419792380573 14.4142;14.4197;54.5478;28.2655;85.6642 9.59235;9.6236;38.2987;22.3101;53.6991 30.0753;29.0958;94.4701;38.3337;224.488 4 1 4 361921;498709;58919;25612 ECT2_8523;CKS2_8325;CCND1_8224;ASNS_8091 35.6909 21.3426 33.949124634664734 23.8062875 15.966849999999999 20.808679760874426 80.4982 34.204499999999996 96.08257409551432 14.4142;14.4197;28.2655;85.6642 9.59235;9.6236;22.3101;53.6991 30.0753;29.0958;38.3337;224.488 1 114851 CDKN1A_8271 54.5478 54.5478 38.2987 38.2987 94.4701 94.4701 54.5478 38.2987 94.4701 0 Exp 2,1(0.2);Linear,2(0.4);Poly 2,2(0.4) 1.7499038899567565 8.838327765464783 1.530501127243042 2.2675669193267822 0.29428617578973965 1.6645443439483643 12.652176093814685 66.27238390618531 9.918268350344874 43.491271649655125 10.150492451403835 156.43466754859617 UP 0.8 0.2 0.0 GO:0045786 6 negative regulation of cell cycle 105 115 9 9 7 7 6 6 63 109 2369 0.96615 0.088414 0.12788 5.22 360243;304477;114851;58919;24770;282840 top2a;kntc1;cdkn1a;ccnd1;ccl2;atf5 TOP2A_10059;KNTC1_8976;CDKN1A_8271;CCND1_8224;CCL2_8218;ATF5_8097 44.419465 41.40665 7.89839 34.300004101908634 47.68766623406918 36.061271050229436 31.683803333333334 30.304399999999998 3.83458 26.044094635221757 34.63685227981338 27.94400278355577 70.12031666666667 66.4019 12.5679 50.29362250534025 70.15770924271735 48.115579667476155 4.5 80.983 13.8391;7.89839;54.5478;28.2655;64.0097;97.9563 9.31624;3.83458;38.2987;22.3101;41.1311;75.2121 27.6952;12.5679;94.4701;38.3337;132.851;114.804 3 3 3 360243;304477;58919 TOP2A_10059;KNTC1_8976;CCND1_8224 16.667663333333333 13.8391 10.474033145643245 11.820306666666667 9.31624 9.488886774587062 26.198933333333333 27.6952 12.947904188065856 13.8391;7.89839;28.2655 9.31624;3.83458;22.3101 27.6952;12.5679;38.3337 3 114851;24770;282840 CDKN1A_8271;CCL2_8218;ATF5_8097 72.17126666666667 64.0097 22.826143912262832 51.54730000000001 41.1311 20.543190884572905 114.04169999999999 114.804 19.20180192507992 54.5478;64.0097;97.9563 38.2987;41.1311;75.2121 94.4701;132.851;114.804 0 Exp 2,1(0.17);Exp 5,1(0.17);Linear,2(0.34);Poly 2,2(0.34) 1.8866464563184455 11.466931223869324 1.559963583946228 2.385996103286743 0.3417271507808318 1.794430136680603 16.973745646484915 71.86518435351508 10.844187394776963 52.52341927188969 29.87703726494822 110.3635960683851 CONFLICT 0.5 0.5 0.0 GO:1901575 4 organic substance catabolic process 296 332 14 13 13 11 9 9 60 323 2155 0.58873 0.55449 1.0 2.71 25044;29692;362282;85430;316033;171142;29740;29657;25649 sds;pla2g2a;pck1;herpud1;glb1;ehhadh;eci1;arntl;apoa2 SDS_9798;PLA2G2A_32641;PCK1_9439;HERPUD1_8795;GLB1_8712;EHHADH_8534;ECI1_8520;ARNTL_8086;APOA2_33095 49.37668555555568 53.893 1.16694E-12 33.80827511689059 56.59633759943701 30.194324302227482 31.515282222222353 37.9512 1.16694E-12 19.692023506494582 36.08019547544793 16.733456300798625 87.37834444444456 92.6554 1.16694E-12 58.15704093884725 106.4412621518674 64.77602943667075 64.7394;1.16694E-12;5.51457;53.893;65.9159;32.6956;103.231;38.2177;80.183 43.4259;1.16694E-12;1.34064;37.9512;47.8573;25.6436;49.9975;27.1236;50.2978 126.828;1.16694E-12;39.6721;92.6554;114.587;45.0542;107.244;63.2034;197.161 6 3 6 362282;85430;316033;171142;29740;25649 PCK1_9439;HERPUD1_8795;GLB1_8712;EHHADH_8534;ECI1_8520;APOA2_33095 56.90551166666666 59.90445 34.65632226646124 35.514673333333334 42.904250000000005 19.24511803314977 99.39561666666668 99.9497 57.298802702898286 5.51457;53.893;65.9159;32.6956;103.231;80.183 1.34064;37.9512;47.8573;25.6436;49.9975;50.2978 39.6721;92.6554;114.587;45.0542;107.244;197.161 3 25044;29692;29657 SDS_9798;PLA2G2A_32641;ARNTL_8086 34.31903333333372 38.2177 32.54530963784634 23.516500000000388 27.1236 21.93651238255463 63.343800000000385 63.2034 63.41411656815798 64.7394;1.16694E-12;38.2177 43.4259;1.16694E-12;27.1236 126.828;1.16694E-12;63.2034 0 Exp 2,2(0.23);Exp 3,1(0.12);Hill,2(0.23);Linear,3(0.34);Power,1(0.12) 2.110558978642794 20.22590684890747 1.5270863771438599 4.897102355957031 1.02432189742275 1.9712703227996826 27.28861247918716 71.4647586319242 18.64982686464589 44.38073757979881 49.38241103106437 125.37427785782475 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0001932 8 regulation of protein phosphorylation 371 395 17 17 15 14 13 13 56 382 2096 0.82877 0.26447 0.4027 3.29 24825;29692;24516;24440;24367;361921;116663;498709;114851;58919;24770;287562;81639 tf;pla2g2a;jun;hbb;fgg;ect2;dusp6;cks2;cdkn1a;ccnd1;ccl2;ccl12;alox15 TF_10003;PLA2G2A_32641;JUN_8938;HBB_8782;FGG_8639;ECT2_8523;DUSP6_8506;CKS2_8325;CDKN1A_8271;CCND1_8224;CCL2_8218;CCL12_8217;ALOX15_8036 49.703584615384706 51.412 1.16694E-12 33.01076394937568 49.083550966070526 30.06773399227822 33.339973076923165 36.6131 1.16694E-12 22.712768261969234 34.05294306426949 22.607567831554427 127.87330000000007 94.4701 1.16694E-12 113.95106782428577 133.88246801354686 113.01811758624902 51.412;1.16694E-12;57.7663;91.4283;93.1824;14.4142;45.5478;14.4197;54.5478;28.2655;64.0097;25.5289;105.624 36.6131;1.16694E-12;38.6865;54.7263;51.338;9.59235;33.3115;9.6236;38.2987;22.3101;41.1311;13.9582;83.8302 86.0232;1.16694E-12;109.049;277.036;327.378;30.0753;71.7388;29.0958;94.4701;38.3337;132.851;336.862;129.44 5 8 5 24825;361921;498709;58919;81639 TF_10003;ECT2_8523;CKS2_8325;CCND1_8224;ALOX15_8036 42.82708 28.2655 38.22127880300448 32.39387000000001 22.3101 30.836564632178142 62.593599999999995 38.3337 44.117662383845776 51.412;14.4142;14.4197;28.2655;105.624 36.6131;9.59235;9.6236;22.3101;83.8302 86.0232;30.0753;29.0958;38.3337;129.44 8 29692;24516;24440;24367;116663;114851;24770;287562 PLA2G2A_32641;JUN_8938;HBB_8782;FGG_8639;DUSP6_8506;CDKN1A_8271;CCL2_8218;CCL12_8217 54.001400000000146 56.15705 31.27952436074225 33.931287500000145 38.492599999999996 18.43750236830463 168.67311250000014 120.95 127.28398171128343 1.16694E-12;57.7663;91.4283;93.1824;45.5478;54.5478;64.0097;25.5289 1.16694E-12;38.6865;54.7263;51.338;33.3115;38.2987;41.1311;13.9582 1.16694E-12;109.049;277.036;327.378;71.7388;94.4701;132.851;336.862 0 Exp 2,3(0.24);Hill,1(0.08);Linear,5(0.39);Poly 2,4(0.31) 1.7384839806222312 22.7734192609787 1.5230457782745361 2.2675669193267822 0.23153878171602135 1.6914535760879517 31.75872891992657 67.64844031084284 20.993171605425328 45.686774548421 65.9287939114385 189.81780608856172 DOWN 0.38461538461538464 0.6153846153846154 0.0 GO:0033554 4 cellular response to stress 394 417 21 21 19 19 18 18 51 399 2079 0.98785 0.02504 0.032199 4.32 360847;360243;78968;287877;362282;338475;24587;299923;293502;24516;85430;361921;299691;114851;58919;25612;29657;81639 ube2t;top2a;srebf1;pycr1;pck1;nrep;nefh;ndrg1;kif22;jun;herpud1;ect2;cry1;cdkn1a;ccnd1;asns;arntl;alox15 UBE2T_10125;TOP2A_10059;SREBF1_32750;PYCR1_9631;PCK1_9439;NREP_9364;NEFH_33218;NDRG1_32364;KIF22_8963;JUN_8938;HERPUD1_8795;ECT2_8523;CRY1_8386;CDKN1A_8271;CCND1_8224;ASNS_8091;ARNTL_8086;ALOX15_8036 44.50127055555556 37.73625 5.51457 31.75370047409694 53.16622220809005 30.894713639134004 28.569952222222224 27.57845 1.34064 20.732969282140253 33.48317525106517 19.55704908239954 83.84277777777778 68.51425 18.2059 67.96298932924972 97.33597062227133 69.536234558958 10.9914;13.8391;11.2357;54.7122;5.51457;36.861;79.3182;99.6641;13.2391;57.7663;53.893;14.4142;37.2548;54.5478;28.2655;85.6642;38.2177;105.624 7.86591;9.31624;4.94421;38.3856;1.34064;28.0333;39.4261;42.5546;9.02099;38.6865;37.9512;9.59235;21.8798;38.2987;22.3101;53.6991;27.1236;83.8302 18.2059;27.6952;24.5771;94.9303;39.6721;53.5645;264.141;105.409;25.4349;109.049;92.6554;30.0753;73.8251;94.4701;38.3337;224.488;63.2034;129.44 11 7 11 360847;360243;78968;287877;362282;293502;85430;361921;58919;25612;81639 UBE2T_10125;TOP2A_10059;SREBF1_32750;PYCR1_9631;PCK1_9439;KIF22_8963;HERPUD1_8795;ECT2_8523;CCND1_8224;ASNS_8091;ALOX15_8036 36.126633636363636 14.4142 34.186487094857306 25.29604909090909 9.59235 25.752848275589816 67.77344545454547 38.3337 63.65378258919674 10.9914;13.8391;11.2357;54.7122;5.51457;13.2391;53.893;14.4142;28.2655;85.6642;105.624 7.86591;9.31624;4.94421;38.3856;1.34064;9.02099;37.9512;9.59235;22.3101;53.6991;83.8302 18.2059;27.6952;24.5771;94.9303;39.6721;25.4349;92.6554;30.0753;38.3337;224.488;129.44 7 338475;24587;299923;24516;299691;114851;29657 NREP_9364;NEFH_33218;NDRG1_32364;JUN_8938;CRY1_8386;CDKN1A_8271;ARNTL_8086 57.66141428571429 54.5478 24.048883327882294 33.71465714285714 38.2987 7.876986906776213 109.09458571428571 94.4701 71.53132152377795 36.861;79.3182;99.6641;57.7663;37.2548;54.5478;38.2177 28.0333;39.4261;42.5546;38.6865;21.8798;38.2987;27.1236 53.5645;264.141;105.409;109.049;73.8251;94.4701;63.2034 0 Exp 2,4(0.23);Exp 3,1(0.06);Hill,2(0.12);Linear,5(0.28);Poly 2,5(0.28);Power,1(0.06) 1.929402607597532 36.4829523563385 1.5226441621780396 4.897102355957031 0.8046779288446694 1.7292789220809937 29.831809359328602 59.17073175178251 18.99180908218016 38.14809536226428 52.44547856982244 115.24007698573313 UP 0.6111111111111112 0.3888888888888889 0.0 GO:0051775 3 response to redox state 5 6 2 2 2 2 2 2 67 4 2474 0.99964 0.010113 0.010113 33.33 316351;29657 npas2;arntl NPAS2_9350;ARNTL_8086 48.224450000000004 48.224450000000004 38.2177 14.151681565276949 47.690281850533815 14.131504516547084 31.4593 31.4593 27.1236 6.131605742381064 31.22785693950178 6.122863480390059 81.31765 81.31765 63.2034 25.617418022216818 80.35069715302491 25.580893465797 0.0 38.2177 0.0 38.2177 58.2312;38.2177 35.795;27.1236 99.4319;63.2034 0 2 0 2 316351;29657 NPAS2_9350;ARNTL_8086 48.224450000000004 48.224450000000004 14.151681565276949 31.4593 31.4593 6.131605742381064 81.31765 81.31765 25.617418022216818 58.2312;38.2177 35.795;27.1236 99.4319;63.2034 0 Power,2(1) 4.858859704443858 9.718018054962158 4.820915699005127 4.897102355957031 0.05387210176662475 4.859009027481079 28.611220000000003 67.83768 22.961327999999998 39.957272 45.81372000000001 116.82157999999998 DOWN 0.0 1.0 0.0 GO:0006366 8 transcription by RNA polymerase II 35 40 3 3 3 3 3 3 66 37 2441 0.97836 0.092298 0.092298 7.5 78968;114519;24516 srebf1;nfil3;jun SREBF1_32750;NFIL3_9304;JUN_8938 34.03896666666667 33.1149 11.2357 23.27905944176726 41.30609259735488 21.88522217282741 23.077903333333335 25.603 4.94421 17.01227846271726 28.31107483743571 15.219072262659676 60.08596666666667 46.6318 24.5771 43.81365566719278 73.41394765797209 44.02230269855627 1.0 33.1149 11.2357;33.1149;57.7663 4.94421;25.603;38.6865 24.5771;46.6318;109.049 1 2 1 78968 SREBF1_32750 11.2357 11.2357 4.94421 4.94421 24.5771 24.5771 11.2357 4.94421 24.5771 2 114519;24516 NFIL3_9304;JUN_8938 45.4406 45.4406 17.431172105742025 32.14475 32.14475 9.251431571654184 77.8404 77.8404 44.13562538267699 33.1149;57.7663 25.603;38.6865 46.6318;109.049 0 Exp 2,1(0.34);Hill,1(0.34);Linear,1(0.34) 2.3108641721587966 7.21600866317749 1.5230457782745361 2.857419490814209 0.7641642231705209 2.835543394088745 7.696231045702838 60.381702287630496 3.8266979753751222 42.32910869129155 10.506147915141433 109.66578541819189 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0042742 5 defense response to bacterium 57 66 4 4 4 4 4 4 65 62 2416 0.9686 0.10152 0.10152 6.06 84386;29692;314654;170568 slpi;pla2g2a;myo1f;dmbt1 SLPI_9890;PLA2G2A_32641;MYO1F_32715;DMBT1_32993 42.555075000000286 39.13135 1.16694E-12 40.3305892211995 46.26388794496743 34.431441360354455 28.27985000000029 25.9936 1.16694E-12 27.357386860407154 30.99975631648952 23.67453176025688 92.8250000000003 105.4075 1.16694E-12 67.24870317956515 104.39001999795434 55.851202876672 2.5 74.23845 56.5193;1.16694E-12;91.9576;21.7434 39.3315;1.16694E-12;61.1322;12.6557 100.108;1.16694E-12;110.707;160.485 2 2 2 314654;170568 MYO1F_32715;DMBT1_32993 56.8505 56.8505 49.64893695558848 36.89395 36.89395 34.278061878189675 135.596 135.596 35.198361353903934 91.9576;21.7434 61.1322;12.6557 110.707;160.485 2 84386;29692 SLPI_9890;PLA2G2A_32641 28.259650000000583 28.259650000000583 39.965180297916014 19.665750000000582 19.665750000000582 27.811570364237866 50.054000000000585 50.054000000000585 70.78704565102207 56.5193;1.16694E-12 39.3315;1.16694E-12 100.108;1.16694E-12 0 Hill,1(0.25);Linear,1(0.25);Poly 2,2(0.5) 1.6810001698681503 6.756892085075378 1.5823365449905396 1.988358974456787 0.19956426496585983 1.5930982828140259 3.031097563224776 82.0790524367758 1.4696108768012799 55.090089123199306 26.921270884026427 158.72872911597418 CONFLICT 0.5 0.5 0.0 GO:0046683 5 response to organophosphorus 70 72 8 8 8 7 7 7 62 65 2413 0.99942 0.0028595 0.0028595 9.72 24825;78968;362282;24516;24450;29680;24770 tf;srebf1;pck1;jun;hmgcs2;cyp11a1;ccl2 TF_10003;SREBF1_32750;PCK1_9439;JUN_8938;HMGCS2_8812;CYP11A1_32785;CCL2_8218 37.75082428571428 43.719 5.51457 22.751477292873297 42.315106013391926 19.243532992046834 25.825335714285718 33.4848 1.34064 16.390034044884167 29.57227357648044 13.091252649117138 70.94872857142857 63.9031 24.5771 40.02518456071186 75.33617037037038 38.58400945627925 2.5 37.15875 51.412;11.2357;5.51457;57.7663;30.5985;43.719;64.0097 36.6131;4.94421;1.34064;38.6865;24.577;33.4848;41.1311 86.0232;24.5771;39.6721;109.049;40.5656;63.9031;132.851 5 2 5 24825;78968;362282;24450;29680 TF_10003;SREBF1_32750;PCK1_9439;HMGCS2_8812;CYP11A1_32785 28.495954 30.5985 19.92088961476319 20.191950000000002 24.577 16.228433040278414 50.948220000000006 40.5656 24.127105028307884 51.412;11.2357;5.51457;30.5985;43.719 36.6131;4.94421;1.34064;24.577;33.4848 86.0232;24.5771;39.6721;40.5656;63.9031 2 24516;24770 JUN_8938;CCL2_8218 60.888 60.888 4.41475047766004 39.9088 39.9088 1.7285932372889559 120.95 120.95 16.83055560580231 57.7663;64.0097 38.6865;41.1311 109.049;132.851 0 Exp 2,4(0.58);Hill,2(0.29);Linear,1(0.15) 2.113630923903489 15.411693692207336 1.5230457782745361 3.3687045574188232 0.6982174643444123 2.0048909187316895 20.89629404035708 54.6053545310715 13.683428576744967 37.96724285182647 41.297656903839 100.59980023901815 UP 0.7142857142857143 0.2857142857142857 0.0 GO:0016192 4 vesicle-mediated transport 163 173 6 6 6 6 6 6 63 167 2311 0.81545 0.32627 0.46687 3.47 314654;286918;290350;170568;287562;81639 myo1f;mx2;loxl2;dmbt1;ccl12;alox15 MYO1F_32715;MX2_9268;LOXL2_9150;DMBT1_32993;CCL12_8217;ALOX15_8036 56.99296666666667 48.55195 21.7434 36.14738197859792 52.01892157733014 34.83028276386303 39.82278333333333 33.6802 12.6557 28.553454878835016 36.46391630249233 28.014946651006408 152.27883333333332 129.41649999999998 46.786 98.02103394153048 161.89602694727603 113.17622192884963 91.9576;31.6605;65.4434;21.7434;25.5289;105.624 61.1322;23.5989;43.7615;12.6557;13.9582;83.8302 110.707;46.786;129.393;160.485;336.862;129.44 3 3 3 314654;170568;81639 MYO1F_32715;DMBT1_32993;ALOX15_8036 73.10833333333333 91.9576 45.00510975981875 52.539366666666666 61.1322 36.35697939988047 133.544 129.44 25.141488281324996 91.9576;21.7434;105.624 61.1322;12.6557;83.8302 110.707;160.485;129.44 3 286918;290350;287562 MX2_9268;LOXL2_9150;CCL12_8217 40.8776 31.6605 21.494371981288495 27.1062 23.5989 15.208058314262207 171.0136666666667 129.393 149.449762008286 31.6605;65.4434;25.5289 23.5989;43.7615;13.9582 46.786;129.393;336.862 0 Exp 2,1(0.17);Linear,1(0.17);Poly 2,4(0.67) 1.766068789818119 10.80299162864685 1.5314651727676392 2.6565301418304443 0.42595035735215747 1.645643413066864 28.069037147553217 85.9168961857801 16.975261016735306 62.670305649931365 73.84567104251832 230.71199562414833 CONFLICT 0.5 0.5 0.0 GO:0090279 9 regulation of calcium ion import 17 21 2 2 2 2 2 2 67 19 2459 0.98216 0.1092 0.1092 9.52 100911740;24770 mrln;ccl2 LOC100911740_32571;CCL2_8218 77.50635 77.50635 64.0097 19.08714547660279 73.11587349397591 18.049004253561996 47.84885 47.84885 41.1311 9.500333158631918 45.663557831325306 8.983614328323375 203.093 203.093 132.851 99.3371890482109 180.24319277108432 93.93428419487104 0.5 77.50635 91.003;64.0097 54.5666;41.1311 273.335;132.851 0 2 0 2 100911740;24770 LOC100911740_32571;CCL2_8218 77.50635 77.50635 19.08714547660279 47.84885 47.84885 9.500333158631918 203.093 203.093 99.3371890482109 91.003;64.0097 54.5666;41.1311 273.335;132.851 0 Exp 2,1(0.5);Linear,1(0.5) 1.6831173425074124 3.3759572505950928 1.559963583946228 1.8159936666488647 0.181040607666787 1.6879786252975464 51.052915999999996 103.959784 34.68206 61.01564 65.41868000000002 340.7673199999999 DOWN 0.0 1.0 0.0 GO:0042752 4 regulation of circadian rhythm 33 35 5 5 4 5 4 4 65 31 2447 0.99782 0.013716 0.013716 11.43 360243;316351;299691;29657 top2a;npas2;cry1;arntl TOP2A_10059;NPAS2_9350;CRY1_8386;ARNTL_8086 36.8857 37.73625 13.8391 18.153848082615063 41.30929317155518 13.719602515015966 23.528660000000002 24.5017 9.31624 11.076977809180015 26.144790948301335 8.393801062842622 66.0389 68.51425 27.6952 29.74332838010344 73.99112447351762 22.096776919154216 0.5 25.546950000000002 2.5 48.224450000000004 13.8391;58.2312;37.2548;38.2177 9.31624;35.795;21.8798;27.1236 27.6952;99.4319;73.8251;63.2034 1 3 1 360243 TOP2A_10059 13.8391 13.8391 9.31624 9.31624 27.6952 27.6952 13.8391 9.31624 27.6952 3 316351;299691;29657 NPAS2_9350;CRY1_8386;ARNTL_8086 44.5679 38.2177 11.842555436644586 28.266133333333332 27.1236 7.027605180524405 78.82013333333333 73.8251 18.62360925178933 58.2312;37.2548;38.2177 35.795;21.8798;27.1236 99.4319;73.8251;63.2034 0 Exp 2,1(0.25);Poly 2,1(0.25);Power,2(0.5) 3.0209503997684486 13.474650621414185 1.8622472286224365 4.897102355957031 1.7212348152838082 3.3576505184173584 19.094928879037237 54.67647112096276 12.673221747003579 34.384098252996424 36.890438187498624 95.18736181250136 DOWN 0.25 0.75 0.0 GO:0051702 3 interaction with symbiont 33 36 4 4 4 4 4 4 65 32 2446 0.99752 0.015121 0.015121 11.11 360918;24516;287562;29339 pf4;jun;ccl12;apcs PF4_32963;JUN_8938;CCL12_8217;APCS_8057 72.76729999999999 79.86015 25.5289 38.30074355126804 63.00985226573879 39.58477487927976 41.248850000000004 46.2693 13.9582 20.064404639144744 36.536928358148565 22.346297484794153 237.85175 223.3685 109.049 150.18029475572573 287.5615576549604 136.99890718171923 0.5 41.6476 2.5 103.887 105.82;57.7663;25.5289;101.954 53.8521;38.6865;13.9582;58.4986 109.875;109.049;336.862;395.621 0 4 0 4 360918;24516;287562;29339 PF4_32963;JUN_8938;CCL12_8217;APCS_8057 72.76729999999999 79.86015 38.30074355126804 41.248850000000004 46.2693 20.064404639144744 237.85175 223.3685 150.18029475572573 105.82;57.7663;25.5289;101.954 53.8521;38.6865;13.9582;58.4986 109.875;109.049;336.862;395.621 0 Exp 2,1(0.25);Exp 3,1(0.25);Linear,1(0.25);Poly 2,1(0.25) 1.6249104233660092 6.518842697143555 1.5230457782745361 1.8398383855819702 0.14743411412916202 1.5779792666435242 35.23257131975732 110.30202868024267 21.58573345363815 60.91196654636186 90.67506113938873 385.02843886061123 DOWN 0.0 1.0 0.0 GO:0050830 6 defense response to Gram-positive bacterium 27 33 3 3 3 3 3 3 66 30 2448 0.98884 0.058181 0.058181 9.09 29692;314654;170568 pla2g2a;myo1f;dmbt1 PLA2G2A_32641;MYO1F_32715;DMBT1_32993 37.90033333333372 21.7434 1.16694E-12 48.060741988584496 39.14525819253125 45.54088559806698 24.595966666667053 12.6557 1.16694E-12 32.26784692636472 25.216410103110917 30.753489735636748 90.39733333333372 110.707 1.16694E-12 82.14755459740255 107.36231548392713 76.89500296061121 0.5 10.871700000000583 1.16694E-12;91.9576;21.7434 1.16694E-12;61.1322;12.6557 1.16694E-12;110.707;160.485 2 1 2 314654;170568 MYO1F_32715;DMBT1_32993 56.8505 56.8505 49.64893695558848 36.89395 36.89395 34.278061878189675 135.596 135.596 35.198361353903934 91.9576;21.7434 61.1322;12.6557 110.707;160.485 1 29692 PLA2G2A_32641 1.16694E-12 1.16694E-12 1.16694E-12 1.16694E-12 1.16694E-12 1.16694E-12 1.16694E-12 1.16694E-12 1.16694E-12 0 Hill,1(0.34);Poly 2,2(0.67) 1.7152366860242731 5.174555540084839 1.5863633155822754 1.988358974456787 0.22830322943310302 1.5998332500457764 -16.485516022808604 92.28618268947605 -11.918539547181304 61.11047288051541 -2.5613756764227418 183.35604234309022 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0071417 5 cellular response to organonitrogen compound 203 213 10 10 9 9 8 8 61 205 2273 0.8824 0.21529 0.3726 3.76 24825;78968;362282;79438;24450;29680;84032;24770 tf;srebf1;pck1;igfals;hmgcs2;cyp11a1;col3a1;ccl2 TF_10003;SREBF1_32750;PCK1_9439;IGFALS_8880;HMGCS2_8812;CYP11A1_32785;COL3A1_8354;CCL2_8218 41.84164625 47.5655 5.51457 24.02418054878337 46.97302554521729 22.065689403211167 28.444781250000005 35.048950000000005 1.34064 16.84053228362575 32.33366909905821 14.387099690429189 80.3738875 74.96315 24.5771 45.952176203913744 88.44931154733536 49.608110912134954 51.412;11.2357;5.51457;70.3663;30.5985;43.719;57.8774;64.0097 36.6131;4.94421;1.34064;46.0459;24.577;33.4848;39.4215;41.1311 86.0232;24.5771;39.6721;148.796;40.5656;63.9031;106.603;132.851 5 3 5 24825;78968;362282;24450;29680 TF_10003;SREBF1_32750;PCK1_9439;HMGCS2_8812;CYP11A1_32785 28.495954 30.5985 19.92088961476319 20.191950000000002 24.577 16.228433040278414 50.948220000000006 40.5656 24.127105028307884 51.412;11.2357;5.51457;30.5985;43.719 36.6131;4.94421;1.34064;24.577;33.4848 86.0232;24.5771;39.6721;40.5656;63.9031 3 79438;84032;24770 IGFALS_8880;COL3A1_8354;CCL2_8218 64.08446666666667 64.0097 6.244785692346313 42.19950000000001 41.1311 3.4390082523890393 129.41666666666666 132.851 21.305123710819686 70.3663;57.8774;64.0097 46.0459;39.4215;41.1311 148.796;106.603;132.851 0 Exp 2,4(0.5);Hill,2(0.25);Linear,2(0.25) 2.0404155616765354 17.005703806877136 1.527578592300415 3.3687045574188232 0.6811270388881651 1.8788292407989502 25.19373849107522 58.48955400892477 16.774887764988115 40.11467473501189 48.53065400401483 112.21712099598517 UP 0.625 0.375 0.0 GO:0097327 5 response to antineoplastic agent 75 80 6 6 6 6 6 6 63 74 2404 0.99481 0.019696 0.019696 7.5 362282;24587;79438;29680;24770;25612 pck1;nefh;igfals;cyp11a1;ccl2;asns PCK1_9439;NEFH_33218;IGFALS_8880;CYP11A1_32785;CCL2_8218;ASNS_8091 58.098661666666665 67.18799999999999 5.51457 29.554777621217454 69.89858237872106 20.649133931902703 35.85460666666666 40.2786 1.34064 18.219304198356948 41.658073554103005 12.40702471933551 145.6418666666667 140.8235 39.6721 87.57069097947476 184.63134583792723 78.04515929350198 3.0 70.3663 5.51457;79.3182;70.3663;43.719;64.0097;85.6642 1.34064;39.4261;46.0459;33.4848;41.1311;53.6991 39.6721;264.141;148.796;63.9031;132.851;224.488 3 3 3 362282;29680;25612 PCK1_9439;CYP11A1_32785;ASNS_8091 44.96592333333333 43.719 40.089361564305726 29.50818 33.4848 26.404776336132823 109.3544 63.9031 100.44199682886637 5.51457;43.719;85.6642 1.34064;33.4848;53.6991 39.6721;63.9031;224.488 3 24587;79438;24770 NEFH_33218;IGFALS_8880;CCL2_8218 71.2314 70.3663 7.690828405965331 42.201033333333335 41.1311 3.4371508569356846 181.92933333333335 148.796 71.64237125007331 79.3182;70.3663;64.0097 39.4261;46.0459;41.1311 264.141;148.796;132.851 0 Exp 2,4(0.67);Hill,1(0.17);Linear,1(0.17) 1.7386324280280077 10.548259139060974 1.527578592300415 2.3449018001556396 0.3043480865303664 1.6743554472923279 34.4499142864194 81.74740904691393 21.27612707352288 50.43308625981046 75.57072028793141 215.7130130454019 CONFLICT 0.5 0.5 0.0 GO:0070098 7 chemokine-mediated signaling pathway 23 24 3 3 3 3 3 3 66 21 2457 0.99652 0.025632 0.025632 12.5 360918;24770;287562 pf4;ccl2;ccl12 PF4_32963;CCL2_8218;CCL12_8217 65.11953333333334 64.0097 25.5289 40.157053954732945 44.13851580703461 35.37296912618243 36.3138 41.1311 13.9582 20.378557327985718 24.77488604893647 19.253075942471966 193.196 132.851 109.875 124.94764427951418 265.6848148894759 123.54851747212474 0.5 44.7693 1.5 84.91485 105.82;64.0097;25.5289 53.8521;41.1311;13.9582 109.875;132.851;336.862 0 3 0 3 360918;24770;287562 PF4_32963;CCL2_8218;CCL12_8217 65.11953333333334 64.0097 40.157053954732945 36.3138 41.1311 20.378557327985718 193.196 132.851 124.94764427951418 105.82;64.0097;25.5289 53.8521;41.1311;13.9582 109.875;132.851;336.862 0 Exp 2,1(0.34);Exp 3,1(0.34);Poly 2,1(0.34) 1.6380748918049928 4.931267142295837 1.5314651727676392 1.8398383855819702 0.17040936125097053 1.559963583946228 19.677548948503635 110.56151771816303 13.253291504342808 59.37430849565719 51.80443012360129 334.5875698763988 DOWN 0.0 1.0 0.0 GO:0008584 6 male gonad development 41 45 2 2 2 2 2 2 67 43 2435 0.8793 0.34595 0.34595 4.44 29680;289054 cyp11a1;aspm CYP11A1_32785;ASPM_8092 27.021250000000002 27.021250000000002 10.3235 23.614184511115344 23.977710514881597 23.218601269888126 20.47295 20.47295 7.4611 18.401534741564358 18.101248468390178 18.093273461010845 40.3827 40.3827 16.8623 33.26286867244016 36.095579513360846 32.705651318787076 43.719;10.3235 33.4848;7.4611 63.9031;16.8623 2 0 2 29680;289054 CYP11A1_32785;ASPM_8092 27.021250000000002 27.021250000000002 23.614184511115344 20.47295 20.47295 18.401534741564358 40.3827 40.3827 33.26286867244016 43.719;10.3235 33.4848;7.4611 63.9031;16.8623 0 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.6457589991897366 3.2980509996414185 1.5452834367752075 1.752767562866211 0.14671343254751318 1.6490254998207092 -5.70633999999999 59.748839999999994 -5.0302759999999935 45.976175999999995 -5.717283999999999 86.482684 UP 1.0 0.0 0.0 GO:0006897 5 endocytosis 72 75 3 3 3 3 3 3 66 72 2406 0.85656 0.33203 0.45562 4.0 286918;290350;170568 mx2;loxl2;dmbt1 MX2_9268;LOXL2_9150;DMBT1_32993 39.615766666666666 31.6605 21.7434 22.910416862277597 40.17244654837025 21.961282456348744 26.67203333333333 23.5989 12.6557 15.778967322779186 27.44520425582388 14.816410632042162 112.22133333333333 129.393 46.786 58.76236254894231 101.47650785216113 59.93633059709345 31.6605;65.4434;21.7434 23.5989;43.7615;12.6557 46.786;129.393;160.485 1 2 1 170568 DMBT1_32993 21.7434 21.7434 12.6557 12.6557 160.485 160.485 21.7434 12.6557 160.485 2 286918;290350 MX2_9268;LOXL2_9150 48.55195 48.55195 23.88811767814701 33.6802 33.6802 14.257111186351882 88.0895 88.0895 58.41196987347715 31.6605;65.4434 23.5989;43.7615 46.786;129.393 0 Exp 2,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 1.947265978262372 5.993709564208984 1.5998332500457764 2.6565301418304443 0.5745167961984515 1.7373461723327637 13.69018939500895 65.54134393832439 8.816450911905225 44.52761575476144 45.725460295066924 178.71720637159973 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:2000134 9 negative regulation of G1/S transition of mitotic cell cycle 18 18 4 4 3 3 3 3 66 15 2463 0.99887 0.011601 0.011601 16.67 114851;58919;24770 cdkn1a;ccnd1;ccl2 CDKN1A_8271;CCND1_8224;CCL2_8218 48.940999999999995 54.5478 28.2655 18.51996525617694 46.82108209911869 17.219073445529496 33.9133 38.2987 22.3101 10.147970739019675 33.128902460798905 9.835268615962603 88.55160000000001 94.4701 38.3337 47.535791583921245 80.88351271031249 41.72110682683158 0.0 28.2655 0.5 41.40665 54.5478;28.2655;64.0097 38.2987;22.3101;41.1311 94.4701;38.3337;132.851 1 2 1 58919 CCND1_8224 28.2655 28.2655 22.3101 22.3101 38.3337 38.3337 28.2655 22.3101 38.3337 2 114851;24770 CDKN1A_8271;CCL2_8218 59.27875 59.27875 6.690573652908962 39.7149 39.7149 2.0028092470327894 113.66055 113.66055 27.139394658042768 54.5478;64.0097 38.2987;41.1311 94.4701;132.851 0 Exp 2,1(0.34);Linear,2(0.67) 1.8057459413723569 5.4920748472213745 1.559963583946228 2.2675669193267822 0.3819414968334656 1.6645443439483643 27.98368642496893 69.89831357503107 22.42979006971312 45.39680993028688 34.75978794844696 142.34341205155303 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0090263 8 positive regulation of canonical Wnt signaling pathway 20 22 2 2 2 2 2 2 67 20 2458 0.97973 0.1181 0.1181 9.09 289054;29657 aspm;arntl ASPM_8092;ARNTL_8086 24.2706 24.2706 10.3235 19.724177975773785 30.374347907409323 17.735042142199504 17.29235 17.29235 7.4611 13.903487085080492 21.59485529606283 12.501353905865656 40.03285 40.03285 16.8623 32.76810605764391 50.1731082670249 29.463521499662388 0.5 24.2706 10.3235;38.2177 7.4611;27.1236 16.8623;63.2034 1 1 1 289054 ASPM_8092 10.3235 10.3235 7.4611 7.4611 16.8623 16.8623 10.3235 7.4611 16.8623 1 29657 ARNTL_8086 38.2177 38.2177 27.1236 27.1236 63.2034 63.2034 38.2177 27.1236 63.2034 0 Poly 2,1(0.5);Power,1(0.5) 2.750892793049785 6.442385792732239 1.5452834367752075 4.897102355957031 2.370093887062832 3.2211928963661194 -3.0657159999999983 51.606916 -1.9769000000000005 36.5616 -5.3814279999999926 85.44712799999999 CONFLICT 0.5 0.5 0.0 GO:0010332 6 response to gamma radiation 40 40 3 3 3 3 3 3 66 37 2441 0.97836 0.092298 0.092298 7.5 29680;114851;24770 cyp11a1;cdkn1a;ccl2 CYP11A1_32785;CDKN1A_8271;CCL2_8218 54.092166666666664 54.5478 43.719 10.153020630498741 55.014211378605495 7.297420026374387 37.638200000000005 38.2987 33.4848 3.865704477840913 38.214297108032405 2.738130965068218 97.07473333333333 94.4701 63.9031 34.547667283093574 98.26534040426984 25.442255487964424 1.0 54.5478 43.719;54.5478;64.0097 33.4848;38.2987;41.1311 63.9031;94.4701;132.851 1 2 1 29680 CYP11A1_32785 43.719 43.719 33.4848 33.4848 63.9031 63.9031 43.719 33.4848 63.9031 2 114851;24770 CDKN1A_8271;CCL2_8218 59.27875 59.27875 6.690573652908962 39.7149 39.7149 2.0028092470327894 113.66055 113.66055 27.139394658042768 54.5478;64.0097 38.2987;41.1311 94.4701;132.851 0 Exp 2,2(0.67);Linear,1(0.34) 1.6572119349842227 4.977275490760803 1.559963583946228 1.752767562866211 0.09651756835435707 1.6645443439483643 42.602942246218355 65.58139108711497 33.263743579057476 42.012656420942534 57.98036752202865 136.169099144638 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0032410 5 negative regulation of transporter activity 14 15 2 2 2 2 2 2 67 13 2465 0.99314 0.060519 0.060519 13.33 100911740;25649 mrln;apoa2 LOC100911740_32571;APOA2_33095 85.593 85.593 80.183 7.650895372438474 81.7033148676572 5.317602762754978 52.4322 52.4322 50.2978 3.0184974275291094 50.89760777329529 2.0979466426663405 235.248 235.248 197.161 53.86315195010411 207.86418527993703 37.436513202414105 0.0 80.183 0.5 85.593 91.003;80.183 54.5666;50.2978 273.335;197.161 1 1 1 25649 APOA2_33095 80.183 80.183 50.2978 50.2978 197.161 197.161 80.183 50.2978 197.161 1 100911740 LOC100911740_32571 91.003 91.003 54.5666 54.5666 273.335 273.335 91.003 54.5666 273.335 0 Linear,2(1) 1.8920397515530922 3.7872639894485474 1.8159936666488647 1.9712703227996826 0.10979717652421515 1.8936319947242737 74.98940000000002 96.19659999999999 48.24877600000001 56.615624 160.59748000000002 309.89851999999996 CONFLICT 0.5 0.5 0.0 GO:0044238 3 primary metabolic process 1157 1278 49 45 42 43 35 35 34 1243 1235 0.58472 0.51191 1.0 2.74 360847;360243;24825;78968;25044;83792;287877;29692;362282;114519;290350;293502;24516;24450;85430;362376;316033;24367;171142;29740;116663;24306;25086;499353;29680;299691;84032;297594;58919;24770;287562;25612;29657;25649;81639 ube2t;top2a;tf;srebf1;sds;scd2;pycr1;pla2g2a;pck1;nfil3;loxl2;kif22;jun;hmgcs2;herpud1;herc6;glb1;fgg;ehhadh;eci1;dusp6;cyp4a2;cyp2e1;cyp2c24;cyp11a1;cry1;col3a1;cdca3;ccnd1;ccl2;ccl12;asns;arntl;apoa2;alox15 UBE2T_10125;TOP2A_10059;TF_10003;SREBF1_32750;SDS_9798;SCD_9786;PYCR1_9631;PLA2G2A_32641;PCK1_9439;NFIL3_9304;LOXL2_9150;KIF22_8963;JUN_8938;HMGCS2_8812;HERPUD1_8795;HERC6_8794;GLB1_8712;FGG_8639;EHHADH_8534;ECI1_8520;DUSP6_8506;CYP4A2_8425;CYP2E1_8421;CYP2C24_32875;CYP11A1_32785;CRY1_8386;COL3A1_8354;CDCA3_8260;CCND1_8224;CCL2_8218;CCL12_8217;ASNS_8091;ARNTL_8086;APOA2_33095;ALOX15_8036 46.67292200000003 49.5529 1.16694E-12 28.83636165063022 49.315329855743826 27.173844364716967 31.03821808571432 33.4848 1.16694E-12 18.933439963353887 33.15964785991464 18.45515708015685 97.00252200000003 86.0232 1.16694E-12 80.11143482407594 109.13383999421745 84.5855186445181 10.9914;13.8391;51.412;11.2357;64.7394;83.9984;54.7122;1.16694E-12;5.51457;33.1149;65.4434;13.2391;57.7663;30.5985;53.893;53.833;65.9159;93.1824;32.6956;103.231;45.5478;59.5671;49.5529;10.5651;43.719;37.2548;57.8774;2.6193;28.2655;64.0097;25.5289;85.6642;38.2177;80.183;105.624 7.86591;9.31624;36.6131;4.94421;43.4259;54.1928;38.3856;1.16694E-12;1.34064;25.603;43.7615;9.02099;38.6865;24.577;37.9512;36.3389;47.8573;51.338;25.6436;49.9975;33.3115;43.4174;26.9979;7.63639;33.4848;21.8798;39.4215;0.978353;22.3101;41.1311;13.9582;53.6991;27.1236;50.2978;83.8302 18.2059;27.6952;86.0232;24.5771;126.828;206.18;94.9303;1.16694E-12;39.6721;46.6318;129.393;25.4349;109.049;40.5656;92.6554;98.3689;114.587;327.378;45.0542;107.244;71.7388;99.5908;71.5977;17.0471;63.9031;73.8251;106.603;7.96997;38.3337;132.851;336.862;224.488;63.2034;197.161;129.44 21 14 21 360847;360243;24825;78968;83792;287877;362282;293502;24450;85430;316033;171142;29740;24306;25086;29680;297594;58919;25612;25649;81639 UBE2T_10125;TOP2A_10059;TF_10003;SREBF1_32750;SCD_9786;PYCR1_9631;PCK1_9439;KIF22_8963;HMGCS2_8812;HERPUD1_8795;GLB1_8712;EHHADH_8534;ECI1_8520;CYP4A2_8425;CYP2E1_8421;CYP11A1_32785;CDCA3_8260;CCND1_8224;ASNS_8091;APOA2_33095;ALOX15_8036 46.9748319047619 49.5529 32.05738894333218 31.55817823809524 33.4848 21.51704774472669 83.58615095238095 71.5977 63.12719356999897 10.9914;13.8391;51.412;11.2357;83.9984;54.7122;5.51457;13.2391;30.5985;53.893;65.9159;32.6956;103.231;59.5671;49.5529;43.719;2.6193;28.2655;85.6642;80.183;105.624 7.86591;9.31624;36.6131;4.94421;54.1928;38.3856;1.34064;9.02099;24.577;37.9512;47.8573;25.6436;49.9975;43.4174;26.9979;33.4848;0.978353;22.3101;53.6991;50.2978;83.8302 18.2059;27.6952;86.0232;24.5771;206.18;94.9303;39.6721;25.4349;40.5656;92.6554;114.587;45.0542;107.244;99.5908;71.5977;63.9031;7.96997;38.3337;224.488;197.161;129.44 14 25044;29692;114519;290350;24516;362376;24367;116663;499353;299691;84032;24770;287562;29657 SDS_9798;PLA2G2A_32641;NFIL3_9304;LOXL2_9150;JUN_8938;HERC6_8794;FGG_8639;DUSP6_8506;CYP2C24_32875;CRY1_8386;COL3A1_8354;CCL2_8218;CCL12_8217;ARNTL_8086 46.22005714285723 49.6904 24.35933960765543 30.258277857142946 34.8252 14.972524486233402 117.12707857142867 102.48595 99.63619521129522 64.7394;1.16694E-12;33.1149;65.4434;57.7663;53.833;93.1824;45.5478;10.5651;37.2548;57.8774;64.0097;25.5289;38.2177 43.4259;1.16694E-12;25.603;43.7615;38.6865;36.3389;51.338;33.3115;7.63639;21.8798;39.4215;41.1311;13.9582;27.1236 126.828;1.16694E-12;46.6318;129.393;109.049;98.3689;327.378;71.7388;17.0471;73.8251;106.603;132.851;336.862;63.2034 0 Exp 2,13(0.38);Exp 3,1(0.03);Exp 4,1(0.03);Hill,3(0.09);Linear,9(0.26);Poly 2,7(0.2);Power,1(0.03) 1.9717760699417508 71.53560733795166 1.5089621543884277 4.897102355957031 0.6546395500220402 1.8943853378295898 37.11942189395125 56.22642210604881 24.765560567777534 37.310875603651105 70.4615661623622 123.54347783763785 UP 0.6 0.4 0.0 GO:0006644 5 phospholipid metabolic process 58 63 4 4 4 4 4 4 65 59 2419 0.97372 0.08903 0.08903 6.35 29692;24450;25649;81639 pla2g2a;hmgcs2;apoa2;alox15 PLA2G2A_32641;HMGCS2_8812;APOA2_33095;ALOX15_8036 54.10137500000029 55.390750000000004 1.16694E-12 47.65912280521389 65.58136300411536 41.68549508019433 39.676250000000294 37.437400000000004 1.16694E-12 35.89141396689885 47.32916719341578 31.5665000288225 91.79165000000029 85.00280000000001 1.16694E-12 88.63767706318005 116.70688226337462 84.53643790943194 2.5 92.90350000000001 1.16694E-12;30.5985;80.183;105.624 1.16694E-12;24.577;50.2978;83.8302 1.16694E-12;40.5656;197.161;129.44 3 1 3 24450;25649;81639 HMGCS2_8812;APOA2_33095;ALOX15_8036 72.13516666666668 80.183 38.154713058589934 52.90166666666667 50.2978 29.712295750637193 122.38886666666667 129.44 78.5354613296015 30.5985;80.183;105.624 24.577;50.2978;83.8302 40.5656;197.161;129.44 1 29692 PLA2G2A_32641 1.16694E-12 1.16694E-12 1.16694E-12 1.16694E-12 1.16694E-12 1.16694E-12 1.16694E-12 1.16694E-12 1.16694E-12 0 Exp 2,1(0.25);Hill,1(0.25);Linear,1(0.25);Poly 2,1(0.25) 2.1739071755615673 9.019787430763245 1.6914535760879517 3.3687045574188232 0.7548779963345131 1.9798146486282349 7.395434650890692 100.8073153491099 4.502664312439414 74.84983568756118 4.926726478083822 178.65657352191675 UP 0.75 0.25 0.0 GO:0006796 5 phosphate-containing compound metabolic process 383 419 16 15 14 16 13 13 56 406 2072 0.76576 0.34171 0.62052 3.1 24825;29692;362282;24450;116663;299691;498709;114851;58919;24770;287562;25649;81639 tf;pla2g2a;pck1;hmgcs2;dusp6;cry1;cks2;cdkn1a;ccnd1;ccl2;ccl12;apoa2;alox15 TF_10003;PLA2G2A_32641;PCK1_9439;HMGCS2_8812;DUSP6_8506;CRY1_8386;CKS2_8325;CDKN1A_8271;CCND1_8224;CCL2_8218;CCL12_8217;APOA2_33095;ALOX15_8036 41.76202076923086 37.2548 1.16694E-12 29.883899971959803 47.381705562735206 27.84627319526767 29.013210769230856 24.577 1.16694E-12 22.533083713512646 32.831823684469484 21.338347280149044 97.69526153846164 73.8251 1.16694E-12 89.03768313515282 121.26349036336808 100.23945552975782 51.412;1.16694E-12;5.51457;30.5985;45.5478;37.2548;14.4197;54.5478;28.2655;64.0097;25.5289;80.183;105.624 36.6131;1.16694E-12;1.34064;24.577;33.3115;21.8798;9.6236;38.2987;22.3101;41.1311;13.9582;50.2978;83.8302 86.0232;1.16694E-12;39.6721;40.5656;71.7388;73.8251;29.0958;94.4701;38.3337;132.851;336.862;197.161;129.44 7 6 7 24825;362282;24450;498709;58919;25649;81639 TF_10003;PCK1_9439;HMGCS2_8812;CKS2_8325;CCND1_8224;APOA2_33095;ALOX15_8036 45.145324285714295 30.5985 36.36797904255602 32.65606285714286 24.577 27.776313658589107 80.04162857142857 40.5656 62.870249832193124 51.412;5.51457;30.5985;14.4197;28.2655;80.183;105.624 36.6131;1.34064;24.577;9.6236;22.3101;50.2978;83.8302 86.0232;39.6721;40.5656;29.0958;38.3337;197.161;129.44 6 29692;116663;299691;114851;24770;287562 PLA2G2A_32641;DUSP6_8506;CRY1_8386;CDKN1A_8271;CCL2_8218;CCL12_8217 37.814833333333524 41.401300000000006 22.834979316186157 24.763216666666864 27.59565 15.89005625130556 118.29116666666687 84.14760000000001 115.49008198654383 1.16694E-12;45.5478;37.2548;54.5478;64.0097;25.5289 1.16694E-12;33.3115;21.8798;38.2987;41.1311;13.9582 1.16694E-12;71.7388;73.8251;94.4701;132.851;336.862 0 Exp 2,3(0.24);Hill,2(0.16);Linear,5(0.39);Poly 2,3(0.24) 1.9008682604732823 25.353517413139343 1.530501127243042 3.3687045574188232 0.5066193441713455 1.8622472286224365 25.516947694378057 58.007093844083656 16.76408693093478 41.26233460752694 49.29382563808276 146.0966974388405 CONFLICT 0.5384615384615384 0.46153846153846156 0.0 GO:0043651 8 linoleic acid metabolic process 10 12 3 3 3 3 3 3 66 9 2469 0.99979 0.003514 0.003514 25.0 24306;499353;81639 cyp4a2;cyp2c24;alox15 CYP4A2_8425;CYP2C24_32875;ALOX15_8036 58.58539999999999 59.5671 10.5651 47.53705311091549 62.55413938739128 46.107879043036256 44.961330000000004 43.4174 7.63639 38.12036149438644 48.03466297822917 37.13817257297012 82.02596666666666 99.5908 17.0471 58.2188416247123 87.476978115715 55.56355091031211 0.0 10.5651 0.5 35.0661 59.5671;10.5651;105.624 43.4174;7.63639;83.8302 99.5908;17.0471;129.44 2 1 2 24306;81639 CYP4A2_8425;ALOX15_8036 82.59555 82.59555 32.56714631043068 63.6238 63.6238 28.57616492673572 114.5154 114.5154 21.106571732993476 59.5671;105.624 43.4174;83.8302 99.5908;129.44 1 499353 CYP2C24_32875 10.5651 10.5651 7.63639 7.63639 17.0471 17.0471 10.5651 7.63639 17.0471 0 Exp 2,1(0.34);Poly 2,2(0.67) 1.9504406859223837 5.897144794464111 1.6914535760879517 2.2906150817871094 0.3027735839526571 1.9150761365890503 4.792160396265565 112.37863960373446 1.8240800980358784 88.09857990196413 16.145145454152427 147.9067878791809 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0006790 4 sulfur compound metabolic process 86 101 3 3 2 3 2 2 67 99 2379 0.47882 0.76819 1.0 1.98 24450;24440 hmgcs2;hbb HMGCS2_8812;HBB_8782 61.0134 61.0134 30.5985 43.01316407822145 48.406884155049305 39.144396795991284 39.651650000000004 39.651650000000004 24.577 21.318774478027564 33.40343566814009 19.401282961992 158.8008 158.8008 40.5656 167.20982338989538 109.79409860591635 152.17033704050948 30.5985;91.4283 24.577;54.7263 40.5656;277.036 1 1 1 24450 HMGCS2_8812 30.5985 30.5985 24.577 24.577 40.5656 40.5656 30.5985 24.577 40.5656 1 24440 HBB_8782 91.4283 91.4283 54.7263 54.7263 277.036 277.036 91.4283 54.7263 277.036 0 Exp 2,1(0.5);Linear,1(0.5) 2.4316907264957104 5.124014258384705 1.7553097009658813 3.3687045574188232 1.1408424437293716 2.5620071291923523 1.4001960000000082 120.62660399999999 10.105336000000005 69.197964 -72.940192 390.541792 CONFLICT 0.5 0.5 0.0 GO:0006955 3 immune response 185 212 9 9 9 9 9 9 60 203 2275 0.9436 0.11508 0.17873 4.25 29142;84386;360918;114519;286918;24516;170568;287562;29339 vnn1;slpi;pf4;nfil3;mx2;jun;dmbt1;ccl12;apcs VNN1_10157;SLPI_9890;PF4_32963;NFIL3_9304;MX2_9268;JUN_8938;DMBT1_32993;CCL12_8217;APCS_8057 50.55285555555556 33.1149 20.8684 33.133292396738625 48.74956524454876 30.48545107327901 31.47821111111111 25.603 12.6557 16.986541416548313 30.816005142716534 16.864214173500795 147.99613333333335 109.049 26.5474 131.18486444681793 177.75470859706238 143.36223487520428 20.8684;56.5193;105.82;33.1149;31.6605;57.7663;21.7434;25.5289;101.954 17.1194;39.3315;53.8521;25.603;23.5989;38.6865;12.6557;13.9582;58.4986 26.5474;100.108;109.875;46.6318;46.786;109.049;160.485;336.862;395.621 2 7 2 29142;170568 VNN1_10157;DMBT1_32993 21.3059 21.3059 0.6187184335382291 14.88755 14.88755 3.1563125391823914 93.51620000000001 93.51620000000001 94.70818521585133 20.8684;21.7434 17.1194;12.6557 26.5474;160.485 7 84386;360918;114519;286918;24516;287562;29339 SLPI_9890;PF4_32963;NFIL3_9304;MX2_9268;JUN_8938;CCL12_8217;APCS_8057 58.909128571428575 56.5193 33.12244404814326 36.2184 38.6865 16.281853899356786 163.56182857142858 109.049 142.0527757459848 56.5193;105.82;33.1149;31.6605;57.7663;25.5289;101.954 39.3315;53.8521;25.603;23.5989;38.6865;13.9582;58.4986 100.108;109.875;46.6318;46.786;109.049;336.862;395.621 0 Exp 2,3(0.34);Exp 3,1(0.12);Linear,3(0.34);Poly 2,2(0.23) 1.9179891416292112 17.835330367088318 1.5230457782745361 2.835543394088745 0.5575474044007072 1.6244933605194092 28.90577118968632 72.19993992142479 20.38033738563288 42.576084836589345 62.288688561412286 233.7035781052544 DOWN 0.2222222222222222 0.7777777777777778 0.0 GO:0034116 8 positive regulation of heterotypic cell-cell adhesion 8 9 2 2 2 2 2 2 67 7 2471 0.99858 0.023028 0.023028 22.22 24367;81639 fgg;alox15 FGG_8639;ALOX15_8036 99.4032 99.4032 93.1824 8.797539728810543 102.54563694397284 7.592554602129007 67.5841 67.5841 51.338 22.97545495566949 75.79081695529146 19.828543165131002 228.409 228.409 129.44 139.96330205450283 178.41481245048104 120.79274955280654 0.0 93.1824 0.0 93.1824 93.1824;105.624 51.338;83.8302 327.378;129.44 1 1 1 81639 ALOX15_8036 105.624 105.624 83.8302 83.8302 129.44 129.44 105.624 83.8302 129.44 1 24367 FGG_8639 93.1824 93.1824 51.338 51.338 327.378 327.378 93.1824 51.338 327.378 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.7968897420010683 3.6003518104553223 1.6914535760879517 1.9088982343673706 0.15375659240216868 1.8001759052276611 87.21043200000001 111.59596799999998 35.741744000000004 99.426456 34.429760000000016 422.38824 CONFLICT 0.5 0.5 0.0 GO:0006565 9 L-serine catabolic process 1 1 1 1 1 1 1 1 68 0 2478 1.0 0.027091 0.027091 100.0 25044 sds SDS_9798 64.7394 64.7394 64.7394 64.7394 43.4259 43.4259 43.4259 43.4259 126.828 126.828 126.828 126.828 0.0 64.7394 0.0 64.7394 64.7394 43.4259 126.828 0 1 0 1 25044 SDS_9798 64.7394 64.7394 43.4259 43.4259 126.828 126.828 64.7394 43.4259 126.828 0 Linear,1(1) 1.9179565906524658 1.9179565906524658 1.9179565906524658 1.9179565906524658 0.0 1.9179565906524658 64.7394 64.7394 43.4259 43.4259 126.828 126.828 DOWN 0.0 1.0 0.0 GO:0031347 6 regulation of defense response 154 164 7 7 5 6 4 4 65 160 2318 0.53916 0.6596 1.0 2.44 84386;316351;314654;81639 slpi;npas2;myo1f;alox15 SLPI_9890;NPAS2_9350;MYO1F_32715;ALOX15_8036 78.08302499999999 75.09440000000001 56.5193 24.563511740570974 75.54084983333334 25.27145147434574 55.02222499999999 50.231849999999994 35.795 22.23447960808846 53.72938524796748 23.16174806523887 109.921725 105.4075 99.4319 13.999111194494954 109.45360479268294 14.704456435071942 56.5193;58.2312;91.9576;105.624 39.3315;35.795;61.1322;83.8302 100.108;99.4319;110.707;129.44 2 2 2 314654;81639 MYO1F_32715;ALOX15_8036 98.79079999999999 98.79079999999999 9.663604114407997 72.4812 72.4812 16.049909719372263 120.0735 120.0735 13.246231331967573 91.9576;105.624 61.1322;83.8302 110.707;129.44 2 84386;316351 SLPI_9890;NPAS2_9350 57.37525 57.37525 1.2104960987132383 37.56325 37.56325 2.500683131666328 99.76995 99.76995 0.47807489476129156 56.5193;58.2312 39.3315;35.795 100.108;99.4319 0 Linear,1(0.25);Poly 2,2(0.5);Power,1(0.25) 2.1270259292870786 9.681069135665894 1.5823365449905396 4.820915699005127 1.6012293178707941 1.6389084458351135 54.01078349424047 102.15526650575951 33.232434984073336 76.81201501592666 96.20259602939497 123.64085397060502 CONFLICT 0.5 0.5 0.0 GO:1901362 5 organic cyclic compound biosynthetic process 212 234 8 7 6 8 6 6 63 228 2250 0.54887 0.61964 1.0 2.56 78968;287877;114519;24516;24450;29680 srebf1;pycr1;nfil3;jun;hmgcs2;cyp11a1 SREBF1_32750;PYCR1_9631;NFIL3_9304;JUN_8938;HMGCS2_8812;CYP11A1_32785 38.524433333333334 38.41695 11.2357 17.297602043944316 42.49254880548705 15.82229962082332 27.613518333333335 29.5439 4.94421 12.651330228099205 30.483303469096793 10.536104133642374 63.27615000000001 55.26745 24.5771 32.826672127326574 70.58154218942664 33.296071379598956 11.2357;54.7122;33.1149;57.7663;30.5985;43.719 4.94421;38.3856;25.603;38.6865;24.577;33.4848 24.5771;94.9303;46.6318;109.049;40.5656;63.9031 4 2 4 78968;287877;24450;29680 SREBF1_32750;PYCR1_9631;HMGCS2_8812;CYP11A1_32785 35.06635 37.15875 18.696606976400837 25.3479025 29.030900000000003 14.754610751965807 55.99402500000001 52.234350000000006 30.57039119075568 11.2357;54.7122;30.5985;43.719 4.94421;38.3856;24.577;33.4848 24.5771;94.9303;40.5656;63.9031 2 114519;24516 NFIL3_9304;JUN_8938 45.4406 45.4406 17.431172105742025 32.14475 32.14475 9.251431571654184 77.8404 77.8404 44.13562538267699 33.1149;57.7663 25.603;38.6865 46.6318;109.049 0 Exp 2,3(0.5);Hill,1(0.17);Linear,2(0.34) 2.2238647914710117 13.997601866722107 1.5230457782745361 3.3687045574188232 0.7804756406339297 2.294155478477478 24.683469064746923 52.36539760191973 17.490345815411352 37.73669085125531 37.009341755906306 89.5429582440937 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0045860 8 positive regulation of protein kinase activity 136 148 6 6 6 5 5 5 64 143 2335 0.79073 0.37286 0.5969 3.38 24825;361921;498709;114851;58919 tf;ect2;cks2;cdkn1a;ccnd1 TF_10003;ECT2_8523;CKS2_8325;CDKN1A_8271;CCND1_8224 32.61184 28.2655 14.4142 19.465553472043887 37.637968628541906 18.846963989481925 23.28757 22.3101 9.59235 13.947422237352676 26.98692624090927 13.196198120036584 55.59962 38.3337 29.0958 31.97093920636364 63.25278400429201 32.575558310795174 51.412;14.4142;14.4197;54.5478;28.2655 36.6131;9.59235;9.6236;38.2987;22.3101 86.0232;30.0753;29.0958;94.4701;38.3337 4 1 4 24825;361921;498709;58919 TF_10003;ECT2_8523;CKS2_8325;CCND1_8224 27.127850000000002 21.3426 17.456117948444312 19.5347875 15.966849999999999 12.86409497298424 45.882 34.204499999999996 27.07964208072183 51.412;14.4142;14.4197;28.2655 36.6131;9.59235;9.6236;22.3101 86.0232;30.0753;29.0958;38.3337 1 114851 CDKN1A_8271 54.5478 54.5478 38.2987 38.2987 94.4701 94.4701 54.5478 38.2987 94.4701 0 Linear,3(0.6);Poly 2,2(0.4) 1.8315924852205283 9.247275352478027 1.530501127243042 2.2675669193267822 0.29144345079605105 1.7797720432281494 15.549530093006304 49.6741499069937 11.062115380423782 35.513024619576214 27.575856198982624 83.62338380101738 UP 0.8 0.2 0.0 GO:0009605 3 response to external stimulus 571 616 34 34 33 29 29 29 40 587 1891 0.99972 7.0083E-4 9.0952E-4 4.71 29142;24825;78968;84386;24777;25044;29692;360918;362282;314654;286918;24516;79438;24450;362376;360504;81660;81714;170568;25086;29680;299691;84032;114851;58919;24770;287562;25612;29339 vnn1;tf;srebf1;slpi;slc10a1;sds;pla2g2a;pf4;pck1;myo1f;mx2;jun;igfals;hmgcs2;herc6;hba-a2;gatm;gas5;dmbt1;cyp2e1;cyp11a1;cry1;col3a1;cdkn1a;ccnd1;ccl2;ccl12;asns;apcs VNN1_10157;TF_10003;SREBF1_32750;SLPI_9890;SLC10A1_9832;SDS_9798;PLA2G2A_32641;PF4_32963;PCK1_9439;MYO1F_32715;MX2_9268;JUN_8938;IGFALS_8880;HMGCS2_8812;HERC6_8794;HBA2_32600;GATM_32792;GAS5_8688;DMBT1_32993;CYP2E1_8421;CYP11A1_32785;CRY1_8386;COL3A1_8354;CDKN1A_8271;CCND1_8224;CCL2_8218;CCL12_8217;ASNS_8091;APCS_8057 48.58387896551728 49.5529 1.16694E-12 29.342591195122573 48.33667219239946 25.925734519933766 32.351841379310386 33.4848 1.16694E-12 19.42871047016361 31.998406992971386 16.18504225628754 103.7392482758621 94.4701 1.16694E-12 87.925088586647 120.85956003510785 103.7192386655058 20.8684;51.412;11.2357;56.5193;7.96762;64.7394;1.16694E-12;105.82;5.51457;91.9576;31.6605;57.7663;70.3663;30.5985;53.833;101.406;37.423;39.7267;21.7434;49.5529;43.719;37.2548;57.8774;54.5478;28.2655;64.0097;25.5289;85.6642;101.954 17.1194;36.6131;4.94421;39.3315;6.07525;43.4259;1.16694E-12;53.8521;1.34064;61.1322;23.5989;38.6865;46.0459;24.577;36.3389;84.6435;28.03;30.1129;12.6557;26.9979;33.4848;21.8798;39.4215;38.2987;22.3101;41.1311;13.9582;53.6991;58.4986 26.5474;86.0232;24.5771;100.108;11.4863;126.828;1.16694E-12;109.875;39.6721;110.707;46.786;109.049;148.796;40.5656;98.3689;115.953;55.6613;58.3946;160.485;71.5977;63.9031;73.8251;106.603;94.4701;38.3337;132.851;336.862;224.488;395.621 13 16 13 29142;24825;78968;362282;314654;24450;360504;81714;170568;25086;29680;58919;25612 VNN1_10157;TF_10003;SREBF1_32750;PCK1_9439;MYO1F_32715;HMGCS2_8812;HBA2_32600;GAS5_8688;DMBT1_32993;CYP2E1_8421;CYP11A1_32785;CCND1_8224;ASNS_8091 44.74342076923077 39.7267 30.876694360220004 31.51004230769231 26.9979 23.374598464181208 81.63442307692307 63.9031 58.61923701141339 20.8684;51.412;11.2357;5.51457;91.9576;30.5985;101.406;39.7267;21.7434;49.5529;43.719;28.2655;85.6642 17.1194;36.6131;4.94421;1.34064;61.1322;24.577;84.6435;30.1129;12.6557;26.9979;33.4848;22.3101;53.6991 26.5474;86.0232;24.5771;39.6721;110.707;40.5656;115.953;58.3946;160.485;71.5977;63.9031;38.3337;224.488 16 84386;24777;25044;29692;360918;286918;24516;79438;362376;81660;299691;84032;114851;24770;287562;29339 SLPI_9890;SLC10A1_9832;SDS_9798;PLA2G2A_32641;PF4_32963;MX2_9268;JUN_8938;IGFALS_8880;HERC6_8794;GATM_32792;CRY1_8386;COL3A1_8354;CDKN1A_8271;CCL2_8218;CCL12_8217;APCS_8057 51.70425125000007 55.533550000000005 28.658547590220795 33.03580312500007 38.492599999999996 16.322040113666894 121.69941875000006 103.3555 104.4717594606964 56.5193;7.96762;64.7394;1.16694E-12;105.82;31.6605;57.7663;70.3663;53.833;37.423;37.2548;57.8774;54.5478;64.0097;25.5289;101.954 39.3315;6.07525;43.4259;1.16694E-12;53.8521;23.5989;38.6865;46.0459;36.3389;28.03;21.8798;39.4215;38.2987;41.1311;13.9582;58.4986 100.108;11.4863;126.828;1.16694E-12;109.875;46.786;109.049;148.796;98.3689;55.6613;73.8251;106.603;94.4701;132.851;336.862;395.621 0 Exp 2,12(0.42);Exp 3,1(0.04);Hill,3(0.11);Linear,7(0.25);Poly 2,6(0.21) 1.8995349714059873 56.52139234542847 1.5059963464736938 3.3687045574188232 0.47992737533759494 1.778118371963501 37.904265471377514 59.263492459657044 25.280512295552306 39.423170463068466 71.73778131954657 135.74071523217765 CONFLICT 0.4482758620689655 0.5517241379310345 0.0 GO:0051302 5 regulation of cell division 50 51 4 4 4 3 3 3 66 48 2430 0.95257 0.15842 0.15842 5.88 303575;361921;289054 kif18b;ect2;aspm KIF18B_32882;ECT2_8523;ASPM_8092 9.471499999999999 10.3235 3.6768 5.419166697011637 9.6896143779463 5.5892224673946895 6.05793 7.4611 1.12034 4.406858620003596 6.170289350276696 4.502157911702713 19.562166666666666 16.8623 11.7489 9.456806768319488 20.273941340438615 9.852695556583276 1.5 12.368849999999998 3.6768;14.4142;10.3235 1.12034;9.59235;7.4611 11.7489;30.0753;16.8623 3 0 3 303575;361921;289054 KIF18B_32882;ECT2_8523;ASPM_8092 9.471499999999999 10.3235 5.419166697011637 6.05793 7.4611 4.406858620003596 19.562166666666666 16.8623 9.456806768319488 3.6768;14.4142;10.3235 1.12034;9.59235;7.4611 11.7489;30.0753;16.8623 0 0 Exp 4,1(0.34);Poly 2,2(0.67) 1.7258074283171454 5.194034695625305 1.5452834367752075 1.8689792156219482 0.16719339271531122 1.7797720432281494 3.3391355914458805 15.60386440855412 1.0711000193421887 11.044759980657812 8.860782397274145 30.263550936059197 UP 1.0 0.0 0.0 GO:0050792 5 regulation of viral process 53 56 6 6 6 6 6 6 63 50 2428 0.99936 0.0035417 0.0035417 10.71 360243;84386;286918;24516;287562;29339 top2a;slpi;mx2;jun;ccl12;apcs TOP2A_10059;SLPI_9890;MX2_9268;JUN_8938;CCL12_8217;APCS_8057 47.87801666666667 44.0899 13.8391 31.67901705813592 50.76611121877328 30.729082641179073 30.564990000000005 31.1427 9.31624 18.433222455376594 32.25799251328412 17.652827717596697 169.35353333333333 104.5785 27.6952 156.7019573165143 196.30356915198004 158.1150028567663 1.5 28.5947 4.5 79.86015 13.8391;56.5193;31.6605;57.7663;25.5289;101.954 9.31624;39.3315;23.5989;38.6865;13.9582;58.4986 27.6952;100.108;46.786;109.049;336.862;395.621 1 5 1 360243 TOP2A_10059 13.8391 13.8391 9.31624 9.31624 27.6952 27.6952 13.8391 9.31624 27.6952 5 84386;286918;24516;287562;29339 SLPI_9890;MX2_9268;JUN_8938;CCL12_8217;APCS_8057 54.68579999999999 56.5193 30.114046520851364 34.81474 38.6865 17.00813921753346 197.6852 109.049 157.08040699813583 56.5193;31.6605;57.7663;25.5289;101.954 39.3315;23.5989;38.6865;13.9582;58.4986 100.108;46.786;109.049;336.862;395.621 0 Exp 2,2(0.34);Linear,2(0.34);Poly 2,2(0.34) 1.764425499059645 10.812256336212158 1.5230457782745361 2.6565301418304443 0.4403457718842681 1.6034149527549744 22.529523733849963 73.22650959948336 15.815340151910728 45.31463984808927 43.965853207189284 294.74121345947736 DOWN 0.16666666666666666 0.8333333333333334 0.0 GO:0032270 7 positive regulation of cellular protein metabolic process 403 428 19 19 17 15 15 15 54 413 2065 0.89585 0.17027 0.25539 3.5 24825;78968;29692;24516;85430;24367;361921;299691;498709;114851;58919;24770;287562;29657;81639 tf;srebf1;pla2g2a;jun;herpud1;fgg;ect2;cry1;cks2;cdkn1a;ccnd1;ccl2;ccl12;arntl;alox15 TF_10003;SREBF1_32750;PLA2G2A_32641;JUN_8938;HERPUD1_8795;FGG_8639;ECT2_8523;CRY1_8386;CKS2_8325;CDKN1A_8271;CCND1_8224;CCL2_8218;CCL12_8217;ARNTL_8086;ALOX15_8036 43.318113333333415 38.2177 1.16694E-12 29.869857594472855 44.82558417342453 27.256180088999763 29.15204400000008 27.1236 1.16694E-12 21.49342540975777 30.786190357900082 21.20209310999623 104.52260666666675 86.0232 1.16694E-12 100.44634077630315 116.63546532437593 103.07427169846966 51.412;11.2357;1.16694E-12;57.7663;53.893;93.1824;14.4142;37.2548;14.4197;54.5478;28.2655;64.0097;25.5289;38.2177;105.624 36.6131;4.94421;1.16694E-12;38.6865;37.9512;51.338;9.59235;21.8798;9.6236;38.2987;22.3101;41.1311;13.9582;27.1236;83.8302 86.0232;24.5771;1.16694E-12;109.049;92.6554;327.378;30.0753;73.8251;29.0958;94.4701;38.3337;132.851;336.862;63.2034;129.44 7 8 7 24825;78968;85430;361921;498709;58919;81639 TF_10003;SREBF1_32750;HERPUD1_8795;ECT2_8523;CKS2_8325;CCND1_8224;ALOX15_8036 39.89487142857143 28.2655 33.92086270363782 29.266394285714284 22.3101 27.445324112066807 61.45721428571428 38.3337 41.080001259551615 51.412;11.2357;53.893;14.4142;14.4197;28.2655;105.624 36.6131;4.94421;37.9512;9.59235;9.6236;22.3101;83.8302 86.0232;24.5771;92.6554;30.0753;29.0958;38.3337;129.44 8 29692;24516;24367;299691;114851;24770;287562;29657 PLA2G2A_32641;JUN_8938;FGG_8639;CRY1_8386;CDKN1A_8271;CCL2_8218;CCL12_8217;ARNTL_8086 46.313450000000145 46.38275 27.860267429492527 29.051987500000145 32.711149999999996 16.681453284534218 142.20482500000014 101.75955 123.51122069289013 1.16694E-12;57.7663;93.1824;37.2548;54.5478;64.0097;25.5289;38.2177 1.16694E-12;38.6865;51.338;21.8798;38.2987;41.1311;13.9582;27.1236 1.16694E-12;109.049;327.378;73.8251;94.4701;132.851;336.862;63.2034 0 Exp 2,4(0.27);Hill,2(0.14);Linear,4(0.27);Poly 2,4(0.27);Power,1(0.07) 1.9297247733381433 30.594316124916077 1.5230457782745361 4.897102355957031 0.8678709640100889 1.7797720432281494 28.20187976044795 58.43434690621886 18.274869987780843 40.02921801221932 53.689744678158064 155.35546865517543 CONFLICT 0.4666666666666667 0.5333333333333333 0.0 GO:0050878 4 regulation of body fluid levels 107 110 7 6 4 5 3 3 66 107 2371 0.65207 0.58016 1.0 2.73 25087;24367;58919 kng2l1;fgg;ccnd1 KNG2_8975;FGG_8639;CCND1_8224 65.12826666666666 73.9369 28.2655 33.342840195510256 55.570495013466726 32.672461241689845 42.103566666666666 51.338 22.3101 17.15443479987998 38.082192681800684 18.309647970671406 168.5759 140.016 38.3337 146.6233363303059 123.43517921508273 125.62493080396962 73.9369;93.1824;28.2655 52.6626;51.338;22.3101 140.016;327.378;38.3337 2 1 2 25087;58919 KNG2_8975;CCND1_8224 51.1012 51.1012 32.294556646283276 37.48635 37.48635 21.46245857596467 89.17484999999999 89.17484999999999 71.9002438566449 73.9369;28.2655 52.6626;22.3101 140.016;38.3337 1 24367 FGG_8639 93.1824 93.1824 51.338 51.338 327.378 327.378 93.1824 51.338 327.378 0 Exp 2,2(0.67);Linear,1(0.34) 1.909454775170946 5.78483247756958 1.6083673238754272 2.2675669193267822 0.3300268070866517 1.9088982343673706 27.397291052314635 102.85924228101871 22.69149626963375 61.515637063699586 2.6559755084250014 334.495824491575 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0051640 4 organelle localization 71 74 3 3 3 3 3 3 66 71 2407 0.86153 0.32449 0.45163 4.05 314654;293502;289054 myo1f;kif22;aspm MYO1F_32715;KIF22_8963;ASPM_8092 38.50673333333334 13.2391 10.3235 46.312757868683796 42.69875779098873 47.72883879406832 25.87143 9.02099 7.4611 30.546681324616916 28.628185765540255 31.48980653800812 51.0014 25.4349 16.8623 51.88392208777204 55.81065430746766 53.326730650636115 91.9576;13.2391;10.3235 61.1322;9.02099;7.4611 110.707;25.4349;16.8623 3 0 3 314654;293502;289054 MYO1F_32715;KIF22_8963;ASPM_8092 38.50673333333334 13.2391 46.312757868683796 25.87143 9.02099 30.546681324616916 51.0014 25.4349 51.88392208777204 91.9576;13.2391;10.3235 61.1322;9.02099;7.4611 110.707;25.4349;16.8623 0 0 Poly 2,3(1) 1.5825456752316391 4.74845290184021 1.5452834367752075 1.616806149482727 0.03589294501647979 1.5863633155822754 -13.90108578256784 90.91455244923449 -8.695393983809893 60.43825398380989 -7.710784912617967 109.71358491261797 UP 1.0 0.0 0.0 GO:0071702 5 organic substance transport 316 335 11 11 10 11 10 10 59 325 2153 0.70714 0.42292 0.71785 2.99 29503;24777;29692;286918;85430;24367;170568;114851;29657;25649 slc22a2;slc10a1;pla2g2a;mx2;herpud1;fgg;dmbt1;cdkn1a;arntl;apoa2 SLC22A2_9845;SLC10A1_9832;PLA2G2A_32641;MX2_9268;HERPUD1_8795;FGG_8639;DMBT1_32993;CDKN1A_8271;ARNTL_8086;APOA2_33095 46.321732000000125 46.055350000000004 1.16694E-12 32.022950316879594 45.248109523336325 27.163955074204758 29.369965000000114 32.5374 1.16694E-12 18.515949924412553 29.94044237318916 16.334237944616355 109.57042000000013 93.56275 1.16694E-12 97.74840747759625 104.08172157601014 80.95314633042143 81.8219;7.96762;1.16694E-12;31.6605;53.893;93.1824;21.7434;54.5478;38.2177;80.183 46.3605;6.07525;1.16694E-12;23.5989;37.9512;51.338;12.6557;38.2987;27.1236;50.2978 102.079;11.4863;1.16694E-12;46.786;92.6554;327.378;160.485;94.4701;63.2034;197.161 4 6 4 29503;85430;170568;25649 SLC22A2_9845;HERPUD1_8795;DMBT1_32993;APOA2_33095 59.41032500000001 67.03800000000001 28.184042972028802 36.8163 42.15585 16.91020585583354 138.0951 131.282 49.504255575051296 81.8219;53.893;21.7434;80.183 46.3605;37.9512;12.6557;50.2978 102.079;92.6554;160.485;197.161 6 24777;29692;286918;24367;114851;29657 SLC10A1_9832;PLA2G2A_32641;MX2_9268;FGG_8639;CDKN1A_8271;ARNTL_8086 37.59600333333353 34.939099999999996 33.77611042368333 24.40574166666686 25.36125 19.277166434006975 90.55396666666685 54.9947 121.00939141971843 7.96762;1.16694E-12;31.6605;93.1824;54.5478;38.2177 6.07525;1.16694E-12;23.5989;51.338;38.2987;27.1236 11.4863;1.16694E-12;46.786;327.378;94.4701;63.2034 0 Exp 2,2(0.2);Hill,1(0.1);Linear,3(0.3);Poly 2,3(0.3);Power,1(0.1) 2.094287573218025 22.338287711143494 1.5270863771438599 4.897102355957031 1.0053169674693996 1.9400842785835266 26.473701761649068 66.16976223835117 17.893660338657934 40.84626966134229 48.985329364446216 170.15551063555404 DOWN 0.4 0.6 0.0 GO:0048565 5 digestive tract development 26 28 2 2 2 2 2 2 67 26 2452 0.96157 0.17463 0.17463 7.14 24450;84032 hmgcs2;col3a1 HMGCS2_8812;COL3A1_8354 44.23795 44.23795 30.5985 19.289095173309722 35.21157629826897 14.460924873547919 31.999250000000004 31.999250000000004 24.577 10.496646613323694 27.087321571238352 7.869276227611156 73.5843 73.5843 40.5656 46.695493351928526 51.7330431424767 35.00734561307213 0.5 44.23795 30.5985;57.8774 24.577;39.4215 40.5656;106.603 1 1 1 24450 HMGCS2_8812 30.5985 30.5985 24.577 24.577 40.5656 40.5656 30.5985 24.577 40.5656 1 84032 COL3A1_8354 57.8774 57.8774 39.4215 39.4215 106.603 106.603 57.8774 39.4215 106.603 0 Exp 2,2(1) 2.3139748111405507 4.958181858062744 1.589477300643921 3.3687045574188232 1.258103658537472 2.479090929031372 17.504628000000004 70.971272 17.451640000000005 46.54686 8.867648000000003 138.300952 CONFLICT 0.5 0.5 0.0 GO:0071392 6 cellular response to estradiol stimulus 25 26 2 2 2 2 2 2 67 24 2454 0.96831 0.15528 0.15528 7.69 24587;24770 nefh;ccl2 NEFH_33218;CCL2_8218 71.66395 71.66395 64.0097 10.824744159794273 75.22123000667874 9.584706778674622 40.2786 40.2786 39.4261 1.2056170619233415 39.88240426486022 1.0675066177380224 198.496 198.496 132.851 92.83604930198187 229.00423347008876 82.20114008375485 0.5 71.66395 79.3182;64.0097 39.4261;41.1311 264.141;132.851 0 2 0 2 24587;24770 NEFH_33218;CCL2_8218 71.66395 71.66395 10.824744159794273 40.2786 40.2786 1.2056170619233415 198.496 198.496 92.83604930198187 79.3182;64.0097 39.4261;41.1311 264.141;132.851 0 Exp 2,2(1) 1.6603066907145345 3.3270678520202637 1.559963583946228 1.7671042680740356 0.1464705824063934 1.6635339260101318 56.66161999999999 86.66628 38.607699999999994 41.9495 69.83179999999999 327.16020000000003 DOWN 0.0 1.0 0.0 GO:0090403 7 oxidative stress-induced premature senescence 2 2 1 1 1 1 1 1 68 1 2477 0.99928 0.053458 0.053458 50.0 29657 arntl ARNTL_8086 38.2177 38.2177 38.2177 38.2177 27.1236 27.1236 27.1236 27.1236 63.2034 63.2034 63.2034 63.2034 0.0 38.2177 0.0 38.2177 38.2177 27.1236 63.2034 0 1 0 1 29657 ARNTL_8086 38.2177 38.2177 27.1236 27.1236 63.2034 63.2034 38.2177 27.1236 63.2034 0 Power,1(1) 4.897102355957031 4.897102355957031 4.897102355957031 4.897102355957031 0.0 4.897102355957031 38.2177 38.2177 27.1236 27.1236 63.2034 63.2034 DOWN 0.0 1.0 0.0 GO:0031401 8 positive regulation of protein modification process 319 340 17 17 16 14 14 14 55 326 2152 0.96524 0.067434 0.10352 4.12 24825;78968;29692;24516;24367;361921;299691;498709;114851;58919;24770;287562;29657;81639 tf;srebf1;pla2g2a;jun;fgg;ect2;cry1;cks2;cdkn1a;ccnd1;ccl2;ccl12;arntl;alox15 TF_10003;SREBF1_32750;PLA2G2A_32641;JUN_8938;FGG_8639;ECT2_8523;CRY1_8386;CKS2_8325;CDKN1A_8271;CCND1_8224;CCL2_8218;CCL12_8217;ARNTL_8086;ALOX15_8036 42.56276428571437 37.73625 1.16694E-12 30.848390482153 44.39846338295898 27.883966320688256 28.523532857142936 24.71685 1.16694E-12 22.161274588312175 30.448682445992304 21.688493208451202 105.37026428571437 79.92415 1.16694E-12 104.18240414428175 117.7650467456607 105.59956663202226 51.412;11.2357;1.16694E-12;57.7663;93.1824;14.4142;37.2548;14.4197;54.5478;28.2655;64.0097;25.5289;38.2177;105.624 36.6131;4.94421;1.16694E-12;38.6865;51.338;9.59235;21.8798;9.6236;38.2987;22.3101;41.1311;13.9582;27.1236;83.8302 86.0232;24.5771;1.16694E-12;109.049;327.378;30.0753;73.8251;29.0958;94.4701;38.3337;132.851;336.862;63.2034;129.44 6 8 6 24825;78968;361921;498709;58919;81639 TF_10003;SREBF1_32750;ECT2_8523;CKS2_8325;CCND1_8224;ALOX15_8036 37.56185 21.3426 36.538045984795076 27.81892666666667 15.966849999999999 29.7707173858956 56.25751666666667 34.204499999999996 42.402478930053924 51.412;11.2357;14.4142;14.4197;28.2655;105.624 36.6131;4.94421;9.59235;9.6236;22.3101;83.8302 86.0232;24.5771;30.0753;29.0958;38.3337;129.44 8 29692;24516;24367;299691;114851;24770;287562;29657 PLA2G2A_32641;JUN_8938;FGG_8639;CRY1_8386;CDKN1A_8271;CCL2_8218;CCL12_8217;ARNTL_8086 46.313450000000145 46.38275 27.860267429492527 29.051987500000145 32.711149999999996 16.681453284534218 142.20482500000014 101.75955 123.51122069289013 1.16694E-12;57.7663;93.1824;37.2548;54.5478;64.0097;25.5289;38.2177 1.16694E-12;38.6865;51.338;21.8798;38.2987;41.1311;13.9582;27.1236 1.16694E-12;109.049;327.378;73.8251;94.4701;132.851;336.862;63.2034 0 Exp 2,4(0.29);Hill,2(0.15);Linear,3(0.22);Poly 2,4(0.29);Power,1(0.08) 1.9622520178035818 29.067229747772217 1.5230457782745361 4.897102355957031 0.8885313995891386 1.821009635925293 26.403389149245513 58.72213942218323 16.9147473102272 40.13231840405869 50.796183600349586 159.94434497107915 CONFLICT 0.42857142857142855 0.5714285714285714 0.0 GO:0070372 8 regulation of ERK1 and ERK2 cascade 108 115 9 9 8 7 7 7 62 108 2370 0.98874 0.033847 0.033847 6.09 29692;24516;24367;116663;24770;287562;81639 pla2g2a;jun;fgg;dusp6;ccl2;ccl12;alox15 PLA2G2A_32641;JUN_8938;FGG_8639;DUSP6_8506;CCL2_8218;CCL12_8217;ALOX15_8036 55.951300000000174 57.7663 1.16694E-12 36.710732249484074 54.00065902609567 34.70986690564784 37.4650714285716 38.6865 1.16694E-12 26.86562762141184 37.477378771195866 27.726277470166718 158.18840000000017 129.44 1.16694E-12 127.10206810113914 172.62638911032823 126.85890495857916 4.5 78.59604999999999 1.16694E-12;57.7663;93.1824;45.5478;64.0097;25.5289;105.624 1.16694E-12;38.6865;51.338;33.3115;41.1311;13.9582;83.8302 1.16694E-12;109.049;327.378;71.7388;132.851;336.862;129.44 1 6 1 81639 ALOX15_8036 105.624 105.624 83.8302 83.8302 129.44 129.44 105.624 83.8302 129.44 6 29692;24516;24367;116663;24770;287562 PLA2G2A_32641;JUN_8938;FGG_8639;DUSP6_8506;CCL2_8218;CCL12_8217 47.672516666666866 51.65705 32.27215681539808 29.737550000000194 35.999 19.09219218913812 162.9798000000002 120.95 138.53909102285866 1.16694E-12;57.7663;93.1824;45.5478;64.0097;25.5289 1.16694E-12;38.6865;51.338;33.3115;41.1311;13.9582 1.16694E-12;109.049;327.378;71.7388;132.851;336.862 0 Exp 2,3(0.43);Hill,1(0.15);Linear,1(0.15);Poly 2,2(0.29) 1.6725869861771465 11.77083420753479 1.5230457782745361 1.988358974456787 0.1920602383359623 1.5676488876342773 28.755608965820343 83.14699103418 17.56273596803304 57.36740688911016 64.02987027106944 252.34692972893083 DOWN 0.14285714285714285 0.8571428571428571 0.0 GO:0006090 8 pyruvate metabolic process 20 25 2 2 2 2 2 2 67 23 2455 0.97143 0.14577 0.14577 8.0 25044;362282 sds;pck1 SDS_9798;PCK1_9439 35.126985000000005 35.126985000000005 5.51457 41.87827890762048 51.07442163036193 35.28666566998973 22.38327 22.38327 1.34064 29.75877273399896 33.71554426608579 25.07476170475444 83.25005 83.25005 39.6721 61.628527910416636 106.71847012399465 51.92823861996831 0.5 35.126985000000005 64.7394;5.51457 43.4259;1.34064 126.828;39.6721 1 1 1 362282 PCK1_9439 5.51457 5.51457 1.34064 1.34064 39.6721 39.6721 5.51457 1.34064 39.6721 1 25044 SDS_9798 64.7394 64.7394 43.4259 43.4259 126.828 126.828 64.7394 43.4259 126.828 0 Hill,1(0.5);Linear,1(0.5) 2.1207121120136367 4.2628583908081055 1.9179565906524658 2.3449018001556396 0.3018958528348054 2.1314291954040527 -22.913348399999997 93.1673184 -18.8602848 63.626824799999994 -2.1627320000000054 168.662832 CONFLICT 0.5 0.5 0.0 GO:0009653 3 anatomical structure morphogenesis 282 299 7 7 6 5 4 4 65 295 2183 0.077858 0.96994 0.13199 1.34 24587;24516;361921;84032 nefh;jun;ect2;col3a1 NEFH_33218;JUN_8938;ECT2_8523;COL3A1_8354 52.344025 57.82185 14.4142 27.2414943699711 57.86038916275215 28.038824885452705 31.7816125 39.054 9.59235 14.796924363212279 32.97413374412821 13.878722080946433 127.467075 107.826 30.0753 98.21652054664312 158.17081188173532 110.11490871463587 79.3182;57.7663;14.4142;57.8774 39.4261;38.6865;9.59235;39.4215 264.141;109.049;30.0753;106.603 1 3 1 361921 ECT2_8523 14.4142 14.4142 9.59235 9.59235 30.0753 30.0753 14.4142 9.59235 30.0753 3 24587;24516;84032 NEFH_33218;JUN_8938;COL3A1_8354 64.9873 57.8774 12.411047776477195 39.17803333333333 39.4215 0.42568656701090796 159.931 109.049 90.25679367227708 79.3182;57.7663;57.8774 39.4261;38.6865;39.4215 264.141;109.049;106.603 0 Exp 2,3(0.75);Poly 2,1(0.25) 1.6611102608300423 6.659399390220642 1.5230457782745361 1.7797720432281494 0.128390670048337 1.6782907843589783 25.647360517428332 79.04068948257168 17.280626624051973 46.28259837594803 31.214884864289758 223.71926513571026 DOWN 0.25 0.75 0.0 GO:0070887 4 cellular response to chemical stimulus 594 635 26 25 24 23 22 22 47 613 1865 0.92947 0.11429 0.2032 3.46 24825;78968;24777;287877;360918;362282;114519;24587;299923;286918;24516;79438;24450;24367;361921;29680;84032;58919;24770;287562;25612;81639 tf;srebf1;slc10a1;pycr1;pf4;pck1;nfil3;nefh;ndrg1;mx2;jun;igfals;hmgcs2;fgg;ect2;cyp11a1;col3a1;ccnd1;ccl2;ccl12;asns;alox15 TF_10003;SREBF1_32750;SLC10A1_9832;PYCR1_9631;PF4_32963;PCK1_9439;NFIL3_9304;NEFH_33218;NDRG1_32364;MX2_9268;JUN_8938;IGFALS_8880;HMGCS2_8812;FGG_8639;ECT2_8523;CYP11A1_32785;COL3A1_8354;CCND1_8224;CCL2_8218;CCL12_8217;ASNS_8091;ALOX15_8036 52.610735909090906 53.0621 5.51457 32.2959098624069 54.669656252108965 31.21962258798036 33.20310227272727 37.49935 1.34064 19.54277161230937 34.3537754626721 19.083657345240333 114.44893181818183 100.16965 11.4863 94.31998388053896 127.38685861165747 100.42816745666939 51.412;11.2357;7.96762;54.7122;105.82;5.51457;33.1149;79.3182;99.6641;31.6605;57.7663;70.3663;30.5985;93.1824;14.4142;43.719;57.8774;28.2655;64.0097;25.5289;85.6642;105.624 36.6131;4.94421;6.07525;38.3856;53.8521;1.34064;25.603;39.4261;42.5546;23.5989;38.6865;46.0459;24.577;51.338;9.59235;33.4848;39.4215;22.3101;41.1311;13.9582;53.6991;83.8302 86.0232;24.5771;11.4863;94.9303;109.875;39.6721;46.6318;264.141;105.409;46.786;109.049;148.796;40.5656;327.378;30.0753;63.9031;106.603;38.3337;132.851;336.862;224.488;129.44 10 12 10 24825;78968;287877;362282;24450;361921;29680;58919;25612;81639 TF_10003;SREBF1_32750;PYCR1_9631;PCK1_9439;HMGCS2_8812;ECT2_8523;CYP11A1_32785;CCND1_8224;ASNS_8091;ALOX15_8036 43.115987 37.15875 32.57896051229179 30.877709999999997 29.030900000000003 24.79246398064721 77.20084 52.234350000000006 61.682620688348415 51.412;11.2357;54.7122;5.51457;30.5985;14.4142;43.719;28.2655;85.6642;105.624 36.6131;4.94421;38.3856;1.34064;24.577;9.59235;33.4848;22.3101;53.6991;83.8302 86.0232;24.5771;94.9303;39.6721;40.5656;30.0753;63.9031;38.3337;224.488;129.44 12 24777;360918;114519;24587;299923;286918;24516;79438;24367;84032;24770;287562 SLC10A1_9832;PF4_32963;NFIL3_9304;NEFH_33218;NDRG1_32364;MX2_9268;JUN_8938;IGFALS_8880;FGG_8639;COL3A1_8354;CCL2_8218;CCL12_8217 60.52302666666666 60.94355 31.186082194766247 35.14092916666667 39.4238 14.73766160973088 145.48900833333335 109.462 107.51012453258411 7.96762;105.82;33.1149;79.3182;99.6641;31.6605;57.7663;70.3663;93.1824;57.8774;64.0097;25.5289 6.07525;53.8521;25.603;39.4261;42.5546;23.5989;38.6865;46.0459;51.338;39.4215;41.1311;13.9582 11.4863;109.875;46.6318;264.141;105.409;46.786;109.049;148.796;327.378;106.603;132.851;336.862 0 Exp 2,9(0.41);Exp 3,2(0.1);Hill,2(0.1);Linear,5(0.23);Poly 2,4(0.19) 1.9427091255908155 44.03856599330902 1.5226441621780396 3.3687045574188232 0.5329772321286972 1.7734381556510925 39.11513411776902 66.10633770041281 25.036697774383118 41.36950677107143 75.03511908341997 153.86274455294367 CONFLICT 0.45454545454545453 0.5454545454545454 0.0 GO:0006730 4 one-carbon metabolic process 9 10 1 1 1 1 1 1 68 9 2469 0.97171 0.24053 0.24053 10.0 791259 car14 CAR14_8195 98.1742 98.1742 98.1742 98.1742 55.9966 55.9966 55.9966 55.99660000000001 356.234 356.234 356.234 356.234 0.0 98.1742 0.0 98.1742 98.1742 55.9966 356.234 0 1 0 1 791259 CAR14_8195 98.1742 98.1742 55.9966 55.9966 356.234 356.234 98.1742 55.9966 356.234 0 Exp 2,1(1) 1.5133047103881836 1.5133047103881836 1.5133047103881836 1.5133047103881836 0.0 1.5133047103881836 98.1742 98.1742 55.9966 55.9966 356.234 356.234 DOWN 0.0 1.0 0.0 GO:0090398 5 cellular senescence 15 15 2 2 2 2 2 2 67 13 2465 0.99314 0.060519 0.060519 13.33 114851;29657 cdkn1a;arntl CDKN1A_8271;ARNTL_8086 46.38275 46.38275 38.2177 11.547124447454463 47.208855976224314 11.48787103153121 32.711149999999996 32.711149999999996 27.1236 7.901988990437775 33.276475190593096 7.861440380920115 78.83675 78.83675 63.2034 22.108895595325496 80.41846767024163 21.995445048197887 0.0 38.2177 0.5 46.38275 54.5478;38.2177 38.2987;27.1236 94.4701;63.2034 0 2 0 2 114851;29657 CDKN1A_8271;ARNTL_8086 46.38275 46.38275 11.547124447454463 32.711149999999996 32.711149999999996 7.901988990437775 78.83675 78.83675 22.108895595325496 54.5478;38.2177 38.2987;27.1236 94.4701;63.2034 0 Linear,1(0.5);Power,1(0.5) 2.8550733840559133 6.5616466999053955 1.6645443439483643 4.897102355957031 2.2857636908702337 3.2808233499526978 30.379252 62.386248 21.759552 43.66274799999999 48.195384 109.478116 DOWN 0.0 1.0 0.0 GO:0043207 4 response to external biotic stimulus 357 390 21 21 20 19 19 19 50 371 2107 0.99752 0.0058921 0.0097168 4.87 29142;24825;84386;29692;360918;362282;314654;286918;24516;24450;362376;360504;81714;170568;25086;29680;24770;287562;29339 vnn1;tf;slpi;pla2g2a;pf4;pck1;myo1f;mx2;jun;hmgcs2;herc6;hba-a2;gas5;dmbt1;cyp2e1;cyp11a1;ccl2;ccl12;apcs VNN1_10157;TF_10003;SLPI_9890;PLA2G2A_32641;PF4_32963;PCK1_9439;MYO1F_32715;MX2_9268;JUN_8938;HMGCS2_8812;HERC6_8794;HBA2_32600;GAS5_8688;DMBT1_32993;CYP2E1_8421;CYP11A1_32785;CCL2_8218;CCL12_8217;APCS_8057 50.18898789473689 49.5529 1.16694E-12 31.724529369928327 49.44829430070637 28.592969861332897 33.37226000000007 33.4848 1.16694E-12 21.11803020211655 32.355895179659534 17.72921739133411 110.70366315789481 98.3689 1.16694E-12 98.89454860778723 141.0638079897304 122.25817208594327 20.8684;51.412;56.5193;1.16694E-12;105.82;5.51457;91.9576;31.6605;57.7663;30.5985;53.833;101.406;39.7267;21.7434;49.5529;43.719;64.0097;25.5289;101.954 17.1194;36.6131;39.3315;1.16694E-12;53.8521;1.34064;61.1322;23.5989;38.6865;24.577;36.3389;84.6435;30.1129;12.6557;26.9979;33.4848;41.1311;13.9582;58.4986 26.5474;86.0232;100.108;1.16694E-12;109.875;39.6721;110.707;46.786;109.049;40.5656;98.3689;115.953;58.3946;160.485;71.5977;63.9031;132.851;336.862;395.621 10 9 10 29142;24825;362282;314654;24450;360504;81714;170568;25086;29680 VNN1_10157;TF_10003;PCK1_9439;MYO1F_32715;HMGCS2_8812;HBA2_32600;GAS5_8688;DMBT1_32993;CYP2E1_8421;CYP11A1_32785 45.649907 41.72285 30.483923788027475 32.867714 28.5554 24.164466222032257 77.38487 67.7504 41.52155689740639 20.8684;51.412;5.51457;91.9576;30.5985;101.406;39.7267;21.7434;49.5529;43.719 17.1194;36.6131;1.34064;61.1322;24.577;84.6435;30.1129;12.6557;26.9979;33.4848 26.5474;86.0232;39.6721;110.707;40.5656;115.953;58.3946;160.485;71.5977;63.9031 9 84386;29692;360918;286918;24516;362376;24770;287562;29339 SLPI_9890;PLA2G2A_32641;PF4_32963;MX2_9268;JUN_8938;HERC6_8794;CCL2_8218;CCL12_8217;APCS_8057 55.23241111111125 56.5193 34.127773968588905 33.9328666666668 38.6865 18.597091700652822 147.7245444444446 109.049 130.90534919233718 56.5193;1.16694E-12;105.82;31.6605;57.7663;53.833;64.0097;25.5289;101.954 39.3315;1.16694E-12;53.8521;23.5989;38.6865;36.3389;41.1311;13.9582;58.4986 100.108;1.16694E-12;109.875;46.786;109.049;98.3689;132.851;336.862;395.621 0 Exp 2,8(0.43);Exp 3,1(0.06);Hill,2(0.11);Linear,3(0.16);Poly 2,5(0.27) 1.8729466808404318 36.60238206386566 1.5059963464736938 3.3687045574188232 0.5100705230902601 1.752767562866211 35.92389976802033 64.45407602145349 23.876435542430322 42.8680844575698 66.23525088637403 155.1720754294156 CONFLICT 0.5263157894736842 0.47368421052631576 0.0 GO:1903046 3 meiotic cell cycle process 29 29 4 4 4 3 3 3 66 26 2452 0.99297 0.042049 0.042049 10.34 360243;498709;289054 top2a;cks2;aspm TOP2A_10059;CKS2_8325;ASPM_8092 12.860766666666665 13.8391 10.3235 2.2164308456014123 12.671820820777729 2.3180885727143834 8.800313333333333 9.31624 7.4611 1.1699302571236057 8.700628930980054 1.2236214274984478 24.5511 27.6952 16.8623 6.695420387847207 23.96097100014349 6.989485271429099 0.5 12.081299999999999 1.5 14.1294 13.8391;14.4197;10.3235 9.31624;9.6236;7.4611 27.6952;29.0958;16.8623 3 0 3 360243;498709;289054 TOP2A_10059;CKS2_8325;ASPM_8092 12.860766666666665 13.8391 2.2164308456014123 8.800313333333333 9.31624 1.1699302571236057 24.5511 27.6952 6.695420387847207 13.8391;14.4197;10.3235 9.31624;9.6236;7.4611 27.6952;29.0958;16.8623 0 0 Poly 2,3(1) 1.6485547525479753 4.970169901847839 1.530501127243042 1.8943853378295898 0.2059540291380108 1.5452834367752075 10.352639053784277 15.368894279549057 7.476412617521853 10.124214049144815 16.974518584007868 32.12768141599213 UP 1.0 0.0 0.0 GO:0032147 9 activation of protein kinase activity 77 81 2 2 2 2 2 2 67 79 2399 0.6228 0.65272 1.0 2.47 24825;361921 tf;ect2 TF_10003;ECT2_8523 32.9131 32.9131 14.4142 26.161395268983636 33.993680906713166 26.11672437784059 23.102725 23.102725 9.59235 19.106555557746415 23.891909938971235 19.07393088866194 58.04925 58.04925 30.0753 39.561139483146846 59.683299389712296 39.493588370632544 51.412;14.4142 36.6131;9.59235 86.0232;30.0753 2 0 2 24825;361921 TF_10003;ECT2_8523 32.9131 32.9131 26.161395268983636 23.102725 23.102725 19.106555557746415 58.04925 58.04925 39.561139483146846 51.412;14.4142 36.6131;9.59235 86.0232;30.0753 0 0 Linear,1(0.5);Poly 2,1(0.5) 1.8889808910840418 3.784662961959839 1.7797720432281494 2.0048909187316895 0.1591830834416433 1.8923314809799194 -3.3447439999999915 69.17094399999999 -3.377609999999997 49.583059999999996 3.220308000000003 112.878192 UP 1.0 0.0 0.0 GO:0042592 4 homeostatic process 357 379 15 13 12 12 9 9 60 370 2108 0.41036 0.71933 0.86348 2.37 24825;29692;362282;85430;299691;24770;287562;25649;81639 tf;pla2g2a;pck1;herpud1;cry1;ccl2;ccl12;apoa2;alox15 TF_10003;PLA2G2A_32641;PCK1_9439;HERPUD1_8795;CRY1_8386;CCL2_8218;CCL12_8217;APOA2_33095;ALOX15_8036 47.04666333333346 51.412 1.16694E-12 34.242138359455375 53.14018283363088 32.50007168590406 31.889115555555684 36.6131 1.16694E-12 26.34640456919442 35.75416588518541 25.841352501310762 120.94331111111124 92.6554 1.16694E-12 98.81551196494189 156.98169501058493 109.29963944416701 51.412;1.16694E-12;5.51457;53.893;37.2548;64.0097;25.5289;80.183;105.624 36.6131;1.16694E-12;1.34064;37.9512;21.8798;41.1311;13.9582;50.2978;83.8302 86.0232;1.16694E-12;39.6721;92.6554;73.8251;132.851;336.862;197.161;129.44 5 4 5 24825;362282;85430;25649;81639 TF_10003;PCK1_9439;HERPUD1_8795;APOA2_33095;ALOX15_8036 59.325314000000006 53.893 37.303947962286514 42.006588 37.9512 29.653051818197746 108.99034000000002 92.6554 58.71880461196392 51.412;5.51457;53.893;80.183;105.624 36.6131;1.34064;37.9512;50.2978;83.8302 86.0232;39.6721;92.6554;197.161;129.44 4 29692;299691;24770;287562 PLA2G2A_32641;CRY1_8386;CCL2_8218;CCL12_8217 31.69835000000029 31.39185 26.569060838062047 19.24227500000029 17.919 17.168418620512252 135.88452500000028 103.33805000000001 144.58806324302526 1.16694E-12;37.2548;64.0097;25.5289 1.16694E-12;21.8798;41.1311;13.9582 1.16694E-12;73.8251;132.851;336.862 0 Exp 2,2(0.23);Hill,2(0.23);Linear,3(0.34);Poly 2,2(0.23) 1.8131200264296636 16.481637954711914 1.5270863771438599 2.3449018001556396 0.27721040843409367 1.8622472286224365 24.675132938489284 69.41819372817766 14.676131237015337 49.10209987409604 56.38384329401586 185.50277892820662 CONFLICT 0.5555555555555556 0.4444444444444444 0.0 GO:0030324 5 lung development 38 42 2 2 2 2 2 2 67 40 2438 0.89671 0.3158 0.3158 4.76 78968;24450 srebf1;hmgcs2 SREBF1_32750;HMGCS2_8812 20.9171 20.9171 11.2357 13.691567182758877 25.94699575063923 11.698688362179878 14.760605000000002 14.760605000000002 4.94421 13.882478942611439 19.860636348471935 11.861811922352217 32.57135 32.57135 24.5771 11.30557677100111 36.724700146109825 9.659991265659555 11.2357;30.5985 4.94421;24.577 24.5771;40.5656 2 0 2 78968;24450 SREBF1_32750;HMGCS2_8812 20.9171 20.9171 13.691567182758877 14.760605000000002 14.760605000000002 13.882478942611439 32.57135 32.57135 11.30557677100111 11.2357;30.5985 4.94421;24.577 24.5771;40.5656 0 0 Exp 2,1(0.5);Hill,1(0.5) 3.102547672665675 6.226124048233032 2.857419490814209 3.3687045574188232 0.36153313771553836 3.113062024116516 1.9415559999999985 39.892644 -4.4795292 34.0007392 16.90262 48.240080000000006 UP 1.0 0.0 0.0 GO:0050767 7 regulation of neurogenesis 202 215 7 7 7 7 7 7 62 208 2270 0.77729 0.36355 0.51552 3.26 24825;338475;361921;84032;282840;289054;29657 tf;nrep;ect2;col3a1;atf5;aspm;arntl TF_10003;NREP_9364;ECT2_8523;COL3A1_8354;ATF5_8097;ASPM_8092;ARNTL_8086 43.866014285714286 38.2177 10.3235 29.587449894137475 50.65531232804925 33.188953606186644 31.92243571428571 28.0333 7.4611 22.683978209019294 37.52430977990305 25.9824923479319 67.30510000000001 63.2034 16.8623 37.16405033622323 72.07203134416349 35.76174539624296 51.412;36.861;14.4142;57.8774;97.9563;10.3235;38.2177 36.6131;28.0333;9.59235;39.4215;75.2121;7.4611;27.1236 86.0232;53.5645;30.0753;106.603;114.804;16.8623;63.2034 3 4 3 24825;361921;289054 TF_10003;ECT2_8523;ASPM_8092 25.383233333333333 14.4142 22.634177194308023 17.88885 9.59235 16.25065260804932 44.32026666666667 30.0753 36.71507631346193 51.412;14.4142;10.3235 36.6131;9.59235;7.4611 86.0232;30.0753;16.8623 4 338475;84032;282840;29657 NREP_9364;COL3A1_8354;ATF5_8097;ARNTL_8086 57.7281 48.04755 28.486382339052234 42.447625 33.7274 22.548220638944002 84.543725 84.9032 30.645378712553626 36.861;57.8774;97.9563;38.2177 28.0333;39.4215;75.2121;27.1236 53.5645;106.603;114.804;63.2034 0 Exp 2,1(0.15);Linear,2(0.29);Poly 2,3(0.43);Power,1(0.15) 2.0804621523658007 15.84989619255066 1.5452834367752075 4.897102355957031 1.1973224805695908 1.7797720432281494 21.9473246681421 65.78470390328647 15.117909490017169 48.72696193855426 39.77358622757075 94.83661377242925 CONFLICT 0.42857142857142855 0.5714285714285714 0.0 GO:0006721 6 terpenoid metabolic process 29 34 3 3 3 3 3 3 66 31 2447 0.9876 0.062612 0.062612 8.82 24450;25086;499353 hmgcs2;cyp2e1;cyp2c24 HMGCS2_8812;CYP2E1_8421;CYP2C24_32875 30.238833333333332 30.5985 10.5651 19.49638831407842 27.018916032319797 17.442639465014647 19.73709666666667 24.577 7.63639 10.549195020333697 18.899756353391453 10.46953838308503 43.07013333333333 40.5656 17.0471 27.361405400734334 38.073429917074215 23.94087989961622 0.5 20.5818 30.5985;49.5529;10.5651 24.577;26.9979;7.63639 40.5656;71.5977;17.0471 2 1 2 24450;25086 HMGCS2_8812;CYP2E1_8421 40.0757 40.0757 13.40278477332233 25.78745 25.78745 1.7118348065745292 56.08165 56.08165 21.943008344459038 30.5985;49.5529 24.577;26.9979 40.5656;71.5977 1 499353 CYP2C24_32875 10.5651 10.5651 7.63639 7.63639 17.0471 17.0471 10.5651 7.63639 17.0471 0 Exp 2,1(0.34);Poly 2,2(0.67) 2.5714641053120104 7.862887144088745 2.2035675048828125 3.3687045574188232 0.6490247233741147 2.2906150817871094 8.176593052270388 52.30107361439627 7.799558720608564 31.674634612724766 12.10778837723327 74.03247828943341 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0009893 5 positive regulation of metabolic process 777 837 33 33 28 29 26 26 43 811 1667 0.83998 0.22956 0.43562 3.11 360243;24825;78968;29692;360918;362282;316351;114519;366960;24516;85430;81660;24367;361921;24309;299691;498709;306575;114851;58919;24770;287562;282840;29657;25649;81639 top2a;tf;srebf1;pla2g2a;pf4;pck1;npas2;nfil3;maff;jun;herpud1;gatm;fgg;ect2;dbp;cry1;cks2;ckap2;cdkn1a;ccnd1;ccl2;ccl12;atf5;arntl;apoa2;alox15 TOP2A_10059;TF_10003;SREBF1_32750;PLA2G2A_32641;PF4_32963;PCK1_9439;NPAS2_9350;NFIL3_9304;MAFF_9172;JUN_8938;HERPUD1_8795;GATM_32792;FGG_8639;ECT2_8523;DBP_8439;CRY1_8386;CKS2_8325;CKAP2_8324;CDKN1A_8271;CCND1_8224;CCL2_8218;CCL12_8217;ATF5_8097;ARNTL_8086;APOA2_33095;ALOX15_8036 46.2592411538462 44.456450000000004 1.16694E-12 31.254735044010694 50.70394330064815 28.34458064287965 30.99667230769235 31.9125 1.16694E-12 21.411888212220234 34.85269785720553 21.002847635015033 94.016126923077 79.92415 1.16694E-12 82.92359523875719 109.5526556533455 86.34826470410569 13.8391;51.412;11.2357;1.16694E-12;105.82;5.51457;58.2312;33.1149;58.0695;57.7663;53.893;37.423;93.1824;14.4142;50.6952;37.2548;14.4197;12.1218;54.5478;28.2655;64.0097;25.5289;97.9563;38.2177;80.183;105.624 9.31624;36.6131;4.94421;1.16694E-12;53.8521;1.34064;35.795;25.603;40.1293;38.6865;37.9512;28.03;51.338;9.59235;40.5862;21.8798;9.6236;8.47044;38.2987;22.3101;41.1311;13.9582;75.2121;27.1236;50.2978;83.8302 27.6952;86.0232;24.5771;1.16694E-12;109.875;39.6721;99.4319;46.6318;104.733;109.049;92.6554;55.6613;327.378;30.0753;59.5346;73.8251;29.0958;21.3803;94.4701;38.3337;132.851;336.862;114.804;63.2034;197.161;129.44 12 14 12 360243;24825;78968;362282;366960;85430;361921;498709;306575;58919;25649;81639 TOP2A_10059;TF_10003;SREBF1_32750;PCK1_9439;MAFF_9172;HERPUD1_8795;ECT2_8523;CKS2_8325;CKAP2_8324;CCND1_8224;APOA2_33095;ALOX15_8036 37.41600583333334 21.3426 32.21478279922616 26.201598333333333 15.966849999999999 24.452941955224507 68.40350833333333 39.0029 54.81814726651713 13.8391;51.412;11.2357;5.51457;58.0695;53.893;14.4142;14.4197;12.1218;28.2655;80.183;105.624 9.31624;36.6131;4.94421;1.34064;40.1293;37.9512;9.59235;9.6236;8.47044;22.3101;50.2978;83.8302 27.6952;86.0232;24.5771;39.6721;104.733;92.6554;30.0753;29.0958;21.3803;38.3337;197.161;129.44 14 29692;360918;316351;114519;24516;81660;24367;24309;299691;114851;24770;287562;282840;29657 PLA2G2A_32641;PF4_32963;NPAS2_9350;NFIL3_9304;JUN_8938;GATM_32792;FGG_8639;DBP_8439;CRY1_8386;CDKN1A_8271;CCL2_8218;CCL12_8217;ATF5_8097;ARNTL_8086 53.839157142857225 52.6215 29.43433568935093 35.1067357142858 37.04685 18.338493221955204 115.96980000000009 96.951 97.75683205780781 1.16694E-12;105.82;58.2312;33.1149;57.7663;37.423;93.1824;50.6952;37.2548;54.5478;64.0097;25.5289;97.9563;38.2177 1.16694E-12;53.8521;35.795;25.603;38.6865;28.03;51.338;40.5862;21.8798;38.2987;41.1311;13.9582;75.2121;27.1236 1.16694E-12;109.875;99.4319;46.6318;109.049;55.6613;327.378;59.5346;73.8251;94.4701;132.851;336.862;114.804;63.2034 0 Exp 2,5(0.2);Exp 3,1(0.04);Hill,3(0.12);Linear,7(0.27);Poly 2,8(0.31);Power,2(0.08) 2.160885736864639 60.61330199241638 1.5230457782745361 5.737884044647217 1.1089999569221332 1.9400842785835266 34.245307784311485 58.273174523380895 22.766207453797065 39.22713716158764 62.14132310350011 125.8909307426538 CONFLICT 0.46153846153846156 0.5384615384615384 0.0 GO:0051093 5 negative regulation of developmental process 252 270 12 12 10 12 10 10 59 260 2218 0.89292 0.18927 0.31758 3.7 360918;290350;84032;114851;58919;24770;282840;289054;29657;29339 pf4;loxl2;col3a1;cdkn1a;ccnd1;ccl2;atf5;aspm;arntl;apcs PF4_32963;LOXL2_9150;COL3A1_8354;CDKN1A_8271;CCND1_8224;CCL2_8218;ATF5_8097;ASPM_8092;ARNTL_8086;APCS_8057 62.441529999999986 60.94355 10.3235 32.09347889338445 64.40489353862449 30.704780594571435 40.707040000000006 40.276300000000006 7.4611 19.221352168715317 43.3065811265794 19.606695200044502 120.20165000000001 108.239 16.8623 104.19708814246893 134.51505352576226 119.41147959626275 105.82;65.4434;57.8774;54.5478;28.2655;64.0097;97.9563;10.3235;38.2177;101.954 53.8521;43.7615;39.4215;38.2987;22.3101;41.1311;75.2121;7.4611;27.1236;58.4986 109.875;129.393;106.603;94.4701;38.3337;132.851;114.804;16.8623;63.2034;395.621 2 8 2 58919;289054 CCND1_8224;ASPM_8092 19.2945 19.2945 12.686909868049035 14.8856 14.8856 10.49982859383904 27.598 27.598 15.182572541568842 28.2655;10.3235 22.3101;7.4611 38.3337;16.8623 8 360918;290350;84032;114851;24770;282840;29657;29339 PF4_32963;LOXL2_9150;COL3A1_8354;CDKN1A_8271;CCL2_8218;ATF5_8097;ARNTL_8086;APCS_8057 73.2282875 64.72655 25.226967743634848 47.162400000000005 42.4463 14.871017368694039 143.3525625 112.3395 104.22790831636952 105.82;65.4434;57.8774;54.5478;64.0097;97.9563;38.2177;101.954 53.8521;43.7615;39.4215;38.2987;41.1311;75.2121;27.1236;58.4986 109.875;129.393;106.603;94.4701;132.851;114.804;63.2034;395.621 0 Exp 2,2(0.2);Exp 3,1(0.1);Linear,4(0.4);Poly 2,2(0.2);Power,1(0.1) 1.9693482939172386 21.11161196231842 1.5452834367752075 4.897102355957031 1.0223785768647928 1.700945258140564 42.54978569703955 82.33327430296045 28.79352249797392 52.620557502026074 55.6196256788451 184.7836743211549 DOWN 0.2 0.8 0.0 GO:0080135 5 regulation of cellular response to stress 165 174 11 11 9 10 8 8 61 166 2312 0.95752 0.094819 0.13874 4.6 29142;24825;287877;316351;85430;24440;299691;29657 vnn1;tf;pycr1;npas2;herpud1;hbb;cry1;arntl VNN1_10157;TF_10003;PYCR1_9631;NPAS2_9350;HERPUD1_8795;HBB_8782;CRY1_8386;ARNTL_8086 50.7522 52.6525 20.8684 20.594025181868364 48.79530455632594 16.06928054747189 33.69925 36.20405 17.1194 11.667356622890834 32.244927219578194 9.808171992109367 101.70658750000001 89.33930000000001 26.5474 74.66894942752188 92.28334578310341 54.49029406990427 20.8684;51.412;54.7122;58.2312;53.893;91.4283;37.2548;38.2177 17.1194;36.6131;38.3856;35.795;37.9512;54.7263;21.8798;27.1236 26.5474;86.0232;94.9303;99.4319;92.6554;277.036;73.8251;63.2034 4 4 4 29142;24825;287877;85430 VNN1_10157;TF_10003;PYCR1_9631;HERPUD1_8795 45.2214 52.6525 16.295848843187034 32.517325 37.28215 10.292960638991747 75.039075 89.33930000000001 32.54785853082353 20.8684;51.412;54.7122;53.893 17.1194;36.6131;38.3856;37.9512 26.5474;86.0232;94.9303;92.6554 4 316351;24440;299691;29657 NPAS2_9350;HBB_8782;CRY1_8386;ARNTL_8086 56.283 48.224450000000004 25.347025168383496 34.881175 31.4593 14.420815790233013 128.3741 86.6285 100.26768338127029 58.2312;91.4283;37.2548;38.2177 35.795;54.7263;21.8798;27.1236 99.4319;277.036;73.8251;63.2034 0 Exp 2,2(0.25);Linear,4(0.5);Power,2(0.25) 2.381995093855757 21.169917702674866 1.5270863771438599 4.897102355957031 1.4061231994119987 1.933569073677063 36.48126863913486 65.02313136086512 25.614184353163488 41.784315646836525 49.963645425409425 153.44952957459057 CONFLICT 0.5 0.5 0.0 GO:0061041 7 regulation of wound healing 71 74 4 4 3 4 3 3 66 71 2407 0.86153 0.32449 0.45163 4.05 24367;114851;24770 fgg;cdkn1a;ccl2 FGG_8639;CDKN1A_8271;CCL2_8218 70.57996666666666 64.0097 54.5478 20.137884256875974 62.76180614963369 16.99606099122163 43.58926666666667 41.1311 38.2987 6.858408973175438 40.99601309109746 5.730771550920084 184.89970000000002 132.851 94.4701 124.8732271120194 140.11467144231483 102.45305764874783 93.1824;54.5478;64.0097 51.338;38.2987;41.1311 327.378;94.4701;132.851 0 3 0 3 24367;114851;24770 FGG_8639;CDKN1A_8271;CCL2_8218 70.57996666666666 64.0097 20.137884256875974 43.58926666666667 41.1311 6.858408973175438 184.89970000000002 132.851 124.8732271120194 93.1824;54.5478;64.0097 51.338;38.2987;41.1311 327.378;94.4701;132.851 0 Exp 2,2(0.67);Linear,1(0.34) 1.7050254608501507 5.133406162261963 1.559963583946228 1.9088982343673706 0.1790723082026053 1.6645443439483643 47.79180538929759 93.36812794403573 35.828246303590916 51.35028702974242 43.59234107610462 326.2070589238954 DOWN 0.0 1.0 0.0 GO:0060548 6 negative regulation of cell death 321 341 15 15 13 12 11 11 58 330 2148 0.79553 0.31386 0.47696 3.23 29142;287877;360918;316351;24516;85430;24367;114851;24770;282840;25612 vnn1;pycr1;pf4;npas2;jun;herpud1;fgg;cdkn1a;ccl2;atf5;asns VNN1_10157;PYCR1_9631;PF4_32963;NPAS2_9350;JUN_8938;HERPUD1_8795;FGG_8639;CDKN1A_8271;CCL2_8218;ATF5_8097;ASNS_8091 67.87740909090908 58.2312 20.8684 25.035469381877185 67.30479541655586 21.734507343710483 43.76989090909091 38.6865 17.1194 14.64773782810536 45.35843721840216 15.317757375896766 129.6800090909091 109.049 26.5474 80.30670166345337 121.22165208182957 62.25289586022362 20.8684;54.7122;105.82;58.2312;57.7663;53.893;93.1824;54.5478;64.0097;97.9563;85.6642 17.1194;38.3856;53.8521;35.795;38.6865;37.9512;51.338;38.2987;41.1311;75.2121;53.6991 26.5474;94.9303;109.875;99.4319;109.049;92.6554;327.378;94.4701;132.851;114.804;224.488 4 7 4 29142;287877;85430;25612 VNN1_10157;PYCR1_9631;HERPUD1_8795;ASNS_8091 53.78445 54.3026 26.461653455708316 36.788825 38.1684 15.019370675314585 109.655275 93.79285 82.86393316095067 20.8684;54.7122;53.893;85.6642 17.1194;38.3856;37.9512;53.6991 26.5474;94.9303;92.6554;224.488 7 360918;316351;24516;24367;114851;24770;282840 PF4_32963;NPAS2_9350;JUN_8938;FGG_8639;CDKN1A_8271;CCL2_8218;ATF5_8097 75.93052857142857 64.0097 22.055516481348825 47.75907142857143 41.1311 13.919301317081759 141.12271428571427 109.875 83.0380039972146 105.82;58.2312;57.7663;93.1824;54.5478;64.0097;97.9563 53.8521;35.795;38.6865;51.338;38.2987;41.1311;75.2121 109.875;99.4319;109.049;327.378;94.4701;132.851;114.804 0 Exp 2,5(0.46);Exp 3,1(0.1);Linear,3(0.28);Poly 2,1(0.1);Power,1(0.1) 1.9672595630223126 23.128597259521484 1.5230457782745361 4.820915699005127 0.9733071600760133 1.6645443439483643 53.08239214139727 82.67242604042092 35.11363101904465 52.426150799137176 82.22178116048889 177.1382370213293 DOWN 0.36363636363636365 0.6363636363636364 0.0 GO:0051851 4 modulation by host of symbiont process 21 22 3 3 3 3 3 3 66 19 2459 0.9975 0.020267 0.020267 13.64 24516;287562;29339 jun;ccl12;apcs JUN_8938;CCL12_8217;APCS_8057 61.749733333333324 57.7663 25.5289 38.367952556050405 59.261185804805066 40.68642270227731 37.04776666666667 38.6865 13.9582 22.315373473086513 35.02072702191323 23.83569435790345 280.5106666666667 336.862 109.049 151.3686968046344 303.12066395318146 135.84405687473176 0.5 41.6476 1.5 79.86015 57.7663;25.5289;101.954 38.6865;13.9582;58.4986 109.049;336.862;395.621 0 3 0 3 24516;287562;29339 JUN_8938;CCL12_8217;APCS_8057 61.749733333333324 57.7663 38.367952556050405 37.04776666666667 38.6865 22.315373473086513 280.5106666666667 336.862 151.3686968046344 57.7663;25.5289;101.954 38.6865;13.9582;58.4986 109.049;336.862;395.621 0 Exp 2,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 1.558999613706913 4.6790043115615845 1.5230457782745361 1.6244933605194092 0.056297930487924905 1.5314651727676392 18.332307769811983 105.16715889685466 11.795544378429739 62.2999889549036 109.22086128647118 451.8004720468622 DOWN 0.0 1.0 0.0 GO:0009267 5 cellular response to starvation 53 55 5 5 5 5 5 5 64 50 2428 0.99677 0.015355 0.015355 9.09 78968;362282;24516;114851;25612 srebf1;pck1;jun;cdkn1a;asns SREBF1_32750;PCK1_9439;JUN_8938;CDKN1A_8271;ASNS_8091 42.945713999999995 54.5478 5.51457 33.85905618920852 55.45968589422126 25.856778017524107 27.39383 38.2987 1.34064 23.028037055615485 36.617413310416104 17.094842718137937 98.45126 94.4701 24.5771 78.93953813503725 117.68831298642941 70.17020668534283 1.5 32.89175 11.2357;5.51457;57.7663;54.5478;85.6642 4.94421;1.34064;38.6865;38.2987;53.6991 24.5771;39.6721;109.049;94.4701;224.488 3 2 3 78968;362282;25612 SREBF1_32750;PCK1_9439;ASNS_8091 34.13815666666667 11.2357 44.71445726284322 19.99465 4.94421 29.244467708236716 96.24573333333335 39.6721 111.31722227985806 11.2357;5.51457;85.6642 4.94421;1.34064;53.6991 24.5771;39.6721;224.488 2 24516;114851 JUN_8938;CDKN1A_8271 56.15705 56.15705 2.2758231752491507 38.492599999999996 38.492599999999996 0.27421600974518423 101.75955 101.75955 10.308839052240765 57.7663;54.5478 38.6865;38.2987 109.049;94.4701 0 Exp 2,2(0.4);Hill,2(0.4);Linear,1(0.2) 1.934750159643017 9.985854744911194 1.5230457782745361 2.857419490814209 0.5825296205584657 1.6645443439483643 13.266942693122346 72.62448530687765 7.208865552061791 47.57879444793821 29.25770403410695 167.64481596589306 UP 0.6 0.4 0.0 GO:0048878 5 chemical homeostasis 274 291 12 10 9 10 7 7 62 284 2194 0.46013 0.68983 0.84964 2.41 24825;362282;85430;299691;24770;287562;25649 tf;pck1;herpud1;cry1;ccl2;ccl12;apoa2 TF_10003;PCK1_9439;HERPUD1_8795;CRY1_8386;CCL2_8218;CCL12_8217;APOA2_33095 45.39942428571429 51.412 5.51457 24.888101703105608 47.819088279846625 23.418470296642234 29.02454857142857 36.6131 1.34064 17.2280397296727 29.989968882826776 15.994020953644366 137.0071142857143 92.6554 39.6721 101.33298624463193 172.5054808400031 113.79549830321417 51.412;5.51457;53.893;37.2548;64.0097;25.5289;80.183 36.6131;1.34064;37.9512;21.8798;41.1311;13.9582;50.2978 86.0232;39.6721;92.6554;73.8251;132.851;336.862;197.161 4 3 4 24825;362282;85430;25649 TF_10003;PCK1_9439;HERPUD1_8795;APOA2_33095 47.7506425 52.6525 31.0208409924343 31.550685 37.28215 21.060989036784733 103.877925 89.33930000000001 66.50527878193203 51.412;5.51457;53.893;80.183 36.6131;1.34064;37.9512;50.2978 86.0232;39.6721;92.6554;197.161 3 299691;24770;287562 CRY1_8386;CCL2_8218;CCL12_8217 42.264466666666664 37.2548 19.723477437899575 25.656366666666667 21.8798 13.974564946478061 181.17936666666665 132.851 138.0174842507403 37.2548;64.0097;25.5289 21.8798;41.1311;13.9582 73.8251;132.851;336.862 0 Exp 2,2(0.29);Hill,1(0.15);Linear,3(0.43);Poly 2,1(0.15) 1.8072241303945333 12.801825404167175 1.5270863771438599 2.3449018001556396 0.30835523637670265 1.8622472286224365 26.96206052666213 63.836788044766436 16.26183813490934 41.7872590079478 61.93858754668328 212.07564102474532 CONFLICT 0.5714285714285714 0.42857142857142855 0.0 GO:0051707 4 response to other organism 231 253 17 17 17 17 17 17 52 236 2242 0.99992 2.6753E-4 2.6753E-4 6.72 29142;24825;84386;29692;360918;362282;314654;286918;24450;362376;360504;81714;170568;25086;24770;287562;29339 vnn1;tf;slpi;pla2g2a;pf4;pck1;myo1f;mx2;hmgcs2;herc6;hba-a2;gas5;dmbt1;cyp2e1;ccl2;ccl12;apcs VNN1_10157;TF_10003;SLPI_9890;PLA2G2A_32641;PF4_32963;PCK1_9439;MYO1F_32715;MX2_9268;HMGCS2_8812;HERC6_8794;HBA2_32600;GAS5_8688;DMBT1_32993;CYP2E1_8421;CCL2_8218;CCL12_8217;APCS_8057 50.12385117647065 49.5529 1.16694E-12 33.556552282879736 49.009872652905436 29.89981803387744 33.05303764705889 30.1129 1.16694E-12 22.35717926025865 31.888526004659035 18.51646735190403 113.55397058823537 98.3689 1.16694E-12 104.19669754975892 145.1676510922739 127.31699324448653 11.5 60.2645 20.8684;51.412;56.5193;1.16694E-12;105.82;5.51457;91.9576;31.6605;30.5985;53.833;101.406;39.7267;21.7434;49.5529;64.0097;25.5289;101.954 17.1194;36.6131;39.3315;1.16694E-12;53.8521;1.34064;61.1322;23.5989;24.577;36.3389;84.6435;30.1129;12.6557;26.9979;41.1311;13.9582;58.4986 26.5474;86.0232;100.108;1.16694E-12;109.875;39.6721;110.707;46.786;40.5656;98.3689;115.953;58.3946;160.485;71.5977;132.851;336.862;395.621 9 8 9 29142;24825;362282;314654;24450;360504;81714;170568;25086 VNN1_10157;TF_10003;PCK1_9439;MYO1F_32715;HMGCS2_8812;HBA2_32600;GAS5_8688;DMBT1_32993;CYP2E1_8421 45.864452222222226 39.7267 32.325075051951444 32.79914888888889 26.9979 25.62925512100403 78.88284444444444 71.5977 43.75271950890915 20.8684;51.412;5.51457;91.9576;30.5985;101.406;39.7267;21.7434;49.5529 17.1194;36.6131;1.34064;61.1322;24.577;84.6435;30.1129;12.6557;26.9979 26.5474;86.0232;39.6721;110.707;40.5656;115.953;58.3946;160.485;71.5977 8 84386;29692;360918;286918;362376;24770;287562;29339 SLPI_9890;PLA2G2A_32641;PF4_32963;MX2_9268;HERC6_8794;CCL2_8218;CCL12_8217;APCS_8057 54.91567500000015 55.17615 36.46998076969775 33.33866250000015 37.8352 19.789582032613136 152.55898750000017 104.9915 139.0821499905764 56.5193;1.16694E-12;105.82;31.6605;53.833;64.0097;25.5289;101.954 39.3315;1.16694E-12;53.8521;23.5989;36.3389;41.1311;13.9582;58.4986 100.108;1.16694E-12;109.875;46.786;98.3689;132.851;336.862;395.621 0 Exp 2,6(0.36);Exp 3,1(0.06);Hill,2(0.12);Linear,3(0.18);Poly 2,5(0.3) 1.9032799882014373 33.326568722724915 1.5059963464736938 3.3687045574188232 0.5285957693473418 1.778118371963501 34.1720787877651 66.07562356517619 22.42510925302399 43.68096604109378 64.02200470100841 163.08593647546235 CONFLICT 0.5294117647058824 0.47058823529411764 0.0 GO:0044237 3 cellular metabolic process 1201 1328 56 53 50 50 43 43 26 1285 1193 0.96765 0.054878 0.088676 3.24 29142;360847;360243;24825;78968;25044;83792;287877;29692;362282;114519;286918;290350;287167;293502;24516;24450;85430;362376;24440;360504;316033;81660;171142;29740;116663;24306;25086;499353;29680;299691;84032;498709;114851;297594;58919;24770;287562;791259;25612;29657;25649;81639 vnn1;ube2t;top2a;tf;srebf1;sds;scd2;pycr1;pla2g2a;pck1;nfil3;mx2;loxl2;hba-a1;kif22;jun;hmgcs2;herpud1;herc6;hbb;hba-a2;glb1;gatm;ehhadh;eci1;dusp6;cyp4a2;cyp2e1;cyp2c24;cyp11a1;cry1;col3a1;cks2;cdkn1a;cdca3;ccnd1;ccl2;ccl12;car14;asns;arntl;apoa2;alox15 VNN1_10157;UBE2T_10125;TOP2A_10059;TF_10003;SREBF1_32750;SDS_9798;SCD_9786;PYCR1_9631;PLA2G2A_32641;PCK1_9439;NFIL3_9304;MX2_9268;LOXL2_9150;LOC287167_9118;KIF22_8963;JUN_8938;HMGCS2_8812;HERPUD1_8795;HERC6_8794;HBB_8782;HBA2_32600;GLB1_8712;GATM_32792;EHHADH_8534;ECI1_8520;DUSP6_8506;CYP4A2_8425;CYP2E1_8421;CYP2C24_32875;CYP11A1_32785;CRY1_8386;COL3A1_8354;CKS2_8325;CDKN1A_8271;CDCA3_8260;CCND1_8224;CCL2_8218;CCL12_8217;CAR14_8195;ASNS_8091;ARNTL_8086;APOA2_33095;ALOX15_8036 48.73257604651164 49.5529 1.16694E-12 30.504748718517725 49.735903081639265 27.37865480103566 33.23442169767445 33.4848 1.16694E-12 21.267687008259113 33.72687252363218 18.49173281889626 97.66839232558142 86.0232 1.16694E-12 81.65031210526067 108.56133189547356 88.51988404753499 20.8684;10.9914;13.8391;51.412;11.2357;64.7394;83.9984;54.7122;1.16694E-12;5.51457;33.1149;31.6605;65.4434;105.203;13.2391;57.7663;30.5985;53.893;53.833;91.4283;101.406;65.9159;37.423;32.6956;103.231;45.5478;59.5671;49.5529;10.5651;43.719;37.2548;57.8774;14.4197;54.5478;2.6193;28.2655;64.0097;25.5289;98.1742;85.6642;38.2177;80.183;105.624 17.1194;7.86591;9.31624;36.6131;4.94421;43.4259;54.1928;38.3856;1.16694E-12;1.34064;25.603;23.5989;43.7615;82.0435;9.02099;38.6865;24.577;37.9512;36.3389;54.7263;84.6435;47.8573;28.03;25.6436;49.9975;33.3115;43.4174;26.9979;7.63639;33.4848;21.8798;39.4215;9.6236;38.2987;0.978353;22.3101;41.1311;13.9582;55.9966;53.6991;27.1236;50.2978;83.8302 26.5474;18.2059;27.6952;86.0232;24.5771;126.828;206.18;94.9303;1.16694E-12;39.6721;46.6318;46.786;129.393;130.247;25.4349;109.049;40.5656;92.6554;98.3689;277.036;115.953;114.587;55.6613;45.0542;107.244;71.7388;99.5908;71.5977;17.0471;63.9031;73.8251;106.603;29.0958;94.4701;7.96997;38.3337;132.851;336.862;356.234;224.488;63.2034;197.161;129.44 25 18 25 29142;360847;360243;24825;78968;83792;287877;362282;287167;293502;24450;85430;360504;316033;171142;29740;24306;25086;29680;498709;297594;58919;25612;25649;81639 VNN1_10157;UBE2T_10125;TOP2A_10059;TF_10003;SREBF1_32750;SCD_9786;PYCR1_9631;PCK1_9439;LOC287167_9118;KIF22_8963;HMGCS2_8812;HERPUD1_8795;HBA2_32600;GLB1_8712;EHHADH_8534;ECI1_8520;CYP4A2_8425;CYP2E1_8421;CYP11A1_32785;CKS2_8325;CDCA3_8260;CCND1_8224;ASNS_8091;APOA2_33095;ALOX15_8036 49.1347428 49.5529 34.4791889891999 34.24606972 33.4848 25.112638747729022 82.28609480000001 71.5977 60.93236103758009 20.8684;10.9914;13.8391;51.412;11.2357;83.9984;54.7122;5.51457;105.203;13.2391;30.5985;53.893;101.406;65.9159;32.6956;103.231;59.5671;49.5529;43.719;14.4197;2.6193;28.2655;85.6642;80.183;105.624 17.1194;7.86591;9.31624;36.6131;4.94421;54.1928;38.3856;1.34064;82.0435;9.02099;24.577;37.9512;84.6435;47.8573;25.6436;49.9975;43.4174;26.9979;33.4848;9.6236;0.978353;22.3101;53.6991;50.2978;83.8302 26.5474;18.2059;27.6952;86.0232;24.5771;206.18;94.9303;39.6721;130.247;25.4349;40.5656;92.6554;115.953;114.587;45.0542;107.244;99.5908;71.5977;63.9031;29.0958;7.96997;38.3337;224.488;197.161;129.44 18 25044;29692;114519;286918;290350;24516;362376;24440;81660;116663;499353;299691;84032;114851;24770;287562;791259;29657 SDS_9798;PLA2G2A_32641;NFIL3_9304;MX2_9268;LOXL2_9150;JUN_8938;HERC6_8794;HBB_8782;GATM_32792;DUSP6_8506;CYP2C24_32875;CRY1_8386;COL3A1_8354;CDKN1A_8271;CCL2_8218;CCL12_8217;CAR14_8195;ARNTL_8086 48.174011111111184 49.6904 24.90152422086278 31.829355000000064 34.8252 14.952113435040816 119.03269444444452 96.4195 101.97094294047669 64.7394;1.16694E-12;33.1149;31.6605;65.4434;57.7663;53.833;91.4283;37.423;45.5478;10.5651;37.2548;57.8774;54.5478;64.0097;25.5289;98.1742;38.2177 43.4259;1.16694E-12;25.603;23.5989;43.7615;38.6865;36.3389;54.7263;28.03;33.3115;7.63639;21.8798;39.4215;38.2987;41.1311;13.9582;55.9966;27.1236 126.828;1.16694E-12;46.6318;46.786;129.393;109.049;98.3689;277.036;55.6613;71.7388;17.0471;73.8251;106.603;94.4701;132.851;336.862;356.234;63.2034 0 Exp 2,16(0.38);Exp 3,1(0.03);Exp 4,1(0.03);Hill,3(0.07);Linear,11(0.26);Poly 2,10(0.24);Power,1(0.03) 1.9560370818834214 87.02632701396942 1.5089621543884277 4.897102355957031 0.6223341799463644 1.8622472286224365 39.61479213337022 57.8503599596531 26.87756964611443 39.59127374923447 73.26334283358551 122.07344181757733 CONFLICT 0.5813953488372093 0.4186046511627907 0.0 GO:0015871 6 choline transport 3 3 1 1 1 1 1 1 68 2 2476 0.99787 0.07912 0.07912 33.33 29503 slc22a2 SLC22A2_9845 81.8219 81.8219 81.8219 81.8219 46.3605 46.3605 46.3605 46.3605 102.079 102.079 102.079 102.079 0.0 81.8219 0.0 81.8219 81.8219 46.3605 102.079 1 0 1 29503 SLC22A2_9845 81.8219 81.8219 46.3605 46.3605 102.079 102.079 81.8219 46.3605 102.079 0 0 Poly 2,1(1) 1.6717280149459839 1.6717280149459839 1.6717280149459839 1.6717280149459839 0.0 1.6717280149459839 81.8219 81.8219 46.3605 46.3605 102.079 102.079 UP 1.0 0.0 0.0 GO:0090304 5 nucleic acid metabolic process 251 278 6 6 6 6 6 6 63 272 2206 0.35898 0.78141 0.69614 2.16 360847;360243;78968;114519;293502;24516 ube2t;top2a;srebf1;nfil3;kif22;jun UBE2T_10125;TOP2A_10059;SREBF1_32750;NFIL3_9304;KIF22_8963;JUN_8938 23.364416666666667 13.539100000000001 10.9914 18.82558103607075 27.25747483248587 21.285952283848513 15.906141666666668 9.168614999999999 4.94421 13.331280327856614 18.741913297058403 14.626183153503266 41.932316666666665 26.56505 18.2059 34.25125097367492 48.66726039538089 39.99749660587556 10.9914;13.8391;11.2357;33.1149;13.2391;57.7663 7.86591;9.31624;4.94421;25.603;9.02099;38.6865 18.2059;27.6952;24.5771;46.6318;25.4349;109.049 4 2 4 360847;360243;78968;293502 UBE2T_10125;TOP2A_10059;SREBF1_32750;KIF22_8963 12.326325 12.237400000000001 1.4251472494096784 7.786837500000001 8.44345 1.9957444696382474 23.978275 25.006 4.066783838510082 10.9914;13.8391;11.2357;13.2391 7.86591;9.31624;4.94421;9.02099 18.2059;27.6952;24.5771;25.4349 2 114519;24516 NFIL3_9304;JUN_8938 45.4406 45.4406 17.431172105742025 32.14475 32.14475 9.251431571654184 77.8404 77.8404 44.13562538267699 33.1149;57.7663 25.603;38.6865 46.6318;109.049 0 Exp 2,1(0.17);Hill,1(0.17);Linear,1(0.17);Poly 2,3(0.5) 2.114294618945693 13.090634226799011 1.5230457782745361 2.857419490814209 0.5920498996830051 2.128909707069397 8.300814567735651 38.428018765597685 5.238895755724368 26.573387577608965 14.52560794041371 69.33902539291962 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0033036 3 macromolecule localization 295 315 7 7 7 7 7 7 62 308 2170 0.36546 0.76861 0.71138 2.22 78968;286918;85430;24367;170568;114851;29657 srebf1;mx2;herpud1;fgg;dmbt1;cdkn1a;arntl SREBF1_32750;MX2_9268;HERPUD1_8795;FGG_8639;DMBT1_32993;CDKN1A_8271;ARNTL_8086 43.497214285714286 38.2177 11.2357 27.02104211186957 41.290442452855494 19.84984447350593 27.987187142857145 27.1236 4.94421 16.004715196512876 28.04391014860914 12.356987509730759 115.6507142857143 92.6554 24.5771 102.9590796227386 95.99203889321068 74.66320924390918 11.2357;31.6605;53.893;93.1824;21.7434;54.5478;38.2177 4.94421;23.5989;37.9512;51.338;12.6557;38.2987;27.1236 24.5771;46.786;92.6554;327.378;160.485;94.4701;63.2034 3 4 3 78968;85430;170568 SREBF1_32750;HERPUD1_8795;DMBT1_32993 28.95736666666667 21.7434 22.224812645404533 18.517036666666666 12.6557 17.26649350201231 92.5725 92.6554 67.9539879249923 11.2357;53.893;21.7434 4.94421;37.9512;12.6557 24.5771;92.6554;160.485 4 286918;24367;114851;29657 MX2_9268;FGG_8639;CDKN1A_8271;ARNTL_8086 54.4021 46.38275 27.58651887244929 35.0898 32.711149999999996 12.514021039085193 132.959375 78.83675 131.11289365022736 31.6605;93.1824;54.5478;38.2177 23.5989;51.338;38.2987;27.1236 46.786;327.378;94.4701;63.2034 0 Exp 2,2(0.29);Hill,1(0.15);Linear,2(0.29);Poly 2,1(0.15);Power,1(0.15) 2.2462779067161 17.111414194107056 1.5270863771438599 4.897102355957031 1.202845747451231 1.9088982343673706 23.479746159447366 63.514682411981205 16.130728202828124 39.84364608288616 39.37756071431231 191.92386785711625 CONFLICT 0.42857142857142855 0.5714285714285714 0.0 GO:0007155 3 cell adhesion 145 150 6 6 5 4 4 4 65 146 2332 0.61609 0.58781 1.0 2.67 29142;79438;24367;84032 vnn1;igfals;fgg;col3a1 VNN1_10157;IGFALS_8880;FGG_8639;COL3A1_8354 60.573625 64.12185 20.8684 30.237962961634295 63.886237700427046 26.383569783249875 38.4812 42.7337 17.1194 15.05249321164659 40.911541334300225 13.610553554168526 152.3311 127.6995 26.5474 127.23536254637176 153.15957898638305 106.8601099135359 20.8684;70.3663;93.1824;57.8774 17.1194;46.0459;51.338;39.4215 26.5474;148.796;327.378;106.603 1 3 1 29142 VNN1_10157 20.8684 20.8684 17.1194 17.1194 26.5474 26.5474 20.8684 17.1194 26.5474 3 79438;24367;84032 IGFALS_8880;FGG_8639;COL3A1_8354 73.8087 70.3663 17.902467555339985 45.6018 46.0459 5.970650020726455 194.25900000000001 148.796 117.19882010071598 70.3663;93.1824;57.8774 46.0459;51.338;39.4215 148.796;327.378;106.603 0 Exp 2,3(0.75);Linear,1(0.25) 1.8706968350933473 7.668198466300964 1.527578592300415 2.642244338989258 0.5115222808322013 1.7491877675056458 30.940421297598405 90.2068287024016 23.729756652586342 53.232643347413656 27.640444704555648 277.02175529544434 DOWN 0.25 0.75 0.0 GO:0034976 5 response to endoplasmic reticulum stress 55 58 4 4 4 4 4 4 65 54 2424 0.981 0.070028 0.070028 6.9 24516;85430;58919;81639 jun;herpud1;ccnd1;alox15 JUN_8938;HERPUD1_8795;CCND1_8224;ALOX15_8036 61.3872 55.82965 28.2655 32.26564445133554 63.50445288497217 35.09802250893497 45.694500000000005 38.31885 22.3101 26.521893702750557 47.82371646567718 28.787832784481846 92.36952500000001 100.85220000000001 38.3337 39.04005255694674 92.59429396567718 42.04019563849017 1.5 55.82965 57.7663;53.893;28.2655;105.624 38.6865;37.9512;22.3101;83.8302 109.049;92.6554;38.3337;129.44 3 1 3 85430;58919;81639 HERPUD1_8795;CCND1_8224;ALOX15_8036 62.594166666666666 53.893 39.40643483726146 48.030499999999996 37.9512 31.974597610759716 86.8097 92.6554 45.83359718907079 53.893;28.2655;105.624 37.9512;22.3101;83.8302 92.6554;38.3337;129.44 1 24516 JUN_8938 57.7663 57.7663 38.6865 38.6865 109.049 109.049 57.7663 38.6865 109.049 0 Exp 2,1(0.25);Linear,2(0.5);Poly 2,1(0.25) 1.7282206449101736 7.00915265083313 1.5230457782745361 2.2675669193267822 0.35236390232913445 1.6092699766159058 29.766868437691166 93.00753156230883 19.70304417130444 71.68595582869555 54.11027349419217 130.62877650580785 UP 0.75 0.25 0.0 GO:1902533 7 positive regulation of intracellular signal transduction 254 269 10 10 8 8 8 8 61 261 2217 0.6982 0.44671 0.69366 2.97 24825;29692;24516;24367;84032;24770;287562;81639 tf;pla2g2a;jun;fgg;col3a1;ccl2;ccl12;alox15 TF_10003;PLA2G2A_32641;JUN_8938;FGG_8639;COL3A1_8354;CCL2_8218;CCL12_8217;ALOX15_8036 56.925087500000146 57.82185 1.16694E-12 33.7946812604093 55.5392079752839 34.84955317844045 38.122325000000146 39.054 1.16694E-12 24.826302697383888 38.287106909038755 27.959414125544914 153.52577500000015 119.2445 1.16694E-12 117.80797327032704 180.08816878287124 123.55837586604063 51.412;1.16694E-12;57.7663;93.1824;57.8774;64.0097;25.5289;105.624 36.6131;1.16694E-12;38.6865;51.338;39.4215;41.1311;13.9582;83.8302 86.0232;1.16694E-12;109.049;327.378;106.603;132.851;336.862;129.44 2 6 2 24825;81639 TF_10003;ALOX15_8036 78.518 78.518 38.333672821685106 60.221650000000004 60.221650000000004 33.38753159796333 107.7316 107.7316 30.700313697420064 51.412;105.624 36.6131;83.8302 86.0232;129.44 6 29692;24516;24367;84032;24770;287562 PLA2G2A_32641;JUN_8938;FGG_8639;COL3A1_8354;CCL2_8218;CCL12_8217 49.72745000000018 57.82185 32.50153610060573 30.75588333333353 39.054 19.479952593721897 168.7905000000002 120.95 134.62261087759336 1.16694E-12;57.7663;93.1824;57.8774;64.0097;25.5289 1.16694E-12;38.6865;51.338;39.4215;41.1311;13.9582 1.16694E-12;109.049;327.378;106.603;132.851;336.862 0 Exp 2,4(0.5);Hill,1(0.13);Linear,1(0.13);Poly 2,2(0.25) 1.7138671679905857 13.797553539276123 1.5230457782745361 2.0048909187316895 0.20924514280728695 1.6404654383659363 33.506568178472264 80.34360682152803 20.918574950672333 55.32607504932797 71.8890145582542 235.16253544174612 DOWN 0.25 0.75 0.0 GO:0010629 7 negative regulation of gene expression 355 375 12 12 10 11 10 10 59 365 2113 0.56175 0.57516 1.0 2.67 78968;114519;290350;24516;299691;114851;58919;282840;29657;25649 srebf1;nfil3;loxl2;jun;cry1;cdkn1a;ccnd1;atf5;arntl;apoa2 SREBF1_32750;NFIL3_9304;LOXL2_9150;JUN_8938;CRY1_8386;CDKN1A_8271;CCND1_8224;ATF5_8097;ARNTL_8086;APOA2_33095 50.39854 46.38275 11.2357 26.013152922114884 55.62622784481158 24.659493813397372 34.811730999999995 32.711149999999996 4.94421 19.2607309593913 38.37003829636161 18.413718754871393 89.14482000000001 84.14760000000001 24.5771 51.46315616869995 99.47965198781016 50.91952830368305 11.2357;33.1149;65.4434;57.7663;37.2548;54.5478;28.2655;97.9563;38.2177;80.183 4.94421;25.603;43.7615;38.6865;21.8798;38.2987;22.3101;75.2121;27.1236;50.2978 24.5771;46.6318;129.393;109.049;73.8251;94.4701;38.3337;114.804;63.2034;197.161 3 7 3 78968;58919;25649 SREBF1_32750;CCND1_8224;APOA2_33095 39.894733333333335 28.2655 35.914646667666574 25.850703333333332 22.3101 22.88315833631873 86.6906 38.3337 95.91711509428336 11.2357;28.2655;80.183 4.94421;22.3101;50.2978 24.5771;38.3337;197.161 7 114519;290350;24516;299691;114851;282840;29657 NFIL3_9304;LOXL2_9150;JUN_8938;CRY1_8386;CDKN1A_8271;ATF5_8097;ARNTL_8086 54.900171428571426 54.5478 22.50033618976351 38.65217142857143 38.2987 18.015553528337133 90.19662857142858 94.4701 30.028065631045617 33.1149;65.4434;57.7663;37.2548;54.5478;97.9563;38.2177 25.603;43.7615;38.6865;21.8798;38.2987;75.2121;27.1236 46.6318;129.393;109.049;73.8251;94.4701;114.804;63.2034 0 Exp 2,2(0.2);Hill,1(0.1);Linear,5(0.5);Poly 2,1(0.1);Power,1(0.1) 2.259673816534793 24.002082109451294 1.5230457782745361 4.897102355957031 0.9929879721145805 2.1194186210632324 34.27542077819507 66.52165922180494 22.873806270646273 46.749655729353734 57.247625341488884 121.04201465851114 DOWN 0.3 0.7 0.0 GO:0010941 5 regulation of cell death 479 511 21 21 18 17 16 16 53 495 1983 0.79384 0.29945 0.54159 3.13 29142;360243;287877;360918;316351;24516;85430;24440;360504;24367;361921;116663;114851;24770;282840;25612 vnn1;top2a;pycr1;pf4;npas2;jun;herpud1;hbb;hba-a2;fgg;ect2;dusp6;cdkn1a;ccl2;atf5;asns VNN1_10157;TOP2A_10059;PYCR1_9631;PF4_32963;NPAS2_9350;JUN_8938;HERPUD1_8795;HBB_8782;HBA2_32600;FGG_8639;ECT2_8523;DUSP6_8506;CDKN1A_8271;CCL2_8218;ATF5_8097;ASNS_8091 63.33043124999999 57.99875 13.8391 30.433340314808678 62.40816329351609 25.761818304417964 42.066168125000004 38.53605 9.31624 20.58211297519901 42.38803427729551 18.057506311901037 121.81115 104.24045000000001 26.5474 85.27694574386834 114.50384922941372 69.03922956682041 20.8684;13.8391;54.7122;105.82;58.2312;57.7663;53.893;91.4283;101.406;93.1824;14.4142;45.5478;54.5478;64.0097;97.9563;85.6642 17.1194;9.31624;38.3856;53.8521;35.795;38.6865;37.9512;54.7263;84.6435;51.338;9.59235;33.3115;38.2987;41.1311;75.2121;53.6991 26.5474;27.6952;94.9303;109.875;99.4319;109.049;92.6554;277.036;115.953;327.378;30.0753;71.7388;94.4701;132.851;114.804;224.488 7 9 7 29142;360243;287877;85430;360504;361921;25612 VNN1_10157;TOP2A_10059;PYCR1_9631;HERPUD1_8795;HBA2_32600;ECT2_8523;ASNS_8091 49.256728571428575 53.893 35.04904914919063 35.815341428571436 37.9512 27.247543904494346 87.47779999999999 92.6554 71.00058583122164 20.8684;13.8391;54.7122;53.893;101.406;14.4142;85.6642 17.1194;9.31624;38.3856;37.9512;84.6435;9.59235;53.6991 26.5474;27.6952;94.9303;92.6554;115.953;30.0753;224.488 9 360918;316351;24516;24440;24367;116663;114851;24770;282840 PF4_32963;NPAS2_9350;JUN_8938;HBB_8782;FGG_8639;DUSP6_8506;CDKN1A_8271;CCL2_8218;ATF5_8097 74.27664444444443 64.0097 22.52040176124267 46.92792222222222 41.1311 13.29256845033889 148.51486666666665 109.875 89.55906862994114 105.82;58.2312;57.7663;91.4283;93.1824;45.5478;54.5478;64.0097;97.9563 53.8521;35.795;38.6865;54.7263;51.338;33.3115;38.2987;41.1311;75.2121 109.875;99.4319;109.049;277.036;327.378;71.7388;94.4701;132.851;114.804 0 Exp 2,5(0.32);Exp 3,1(0.07);Linear,5(0.32);Poly 2,4(0.25);Power,1(0.07) 1.8972175793027142 31.903831601142883 1.5230457782745361 4.820915699005127 0.8142141875093573 1.7667140364646912 48.41809449574375 78.24276800425623 31.98093276715248 52.15140348284753 80.02544658550451 163.59685341449548 CONFLICT 0.4375 0.5625 0.0 GO:1903964 8 monounsaturated fatty acid metabolic process 2 2 1 1 1 1 1 1 68 1 2477 0.99928 0.053458 0.053458 50.0 83792 scd2 SCD_9786 83.9984 83.9984 83.9984 83.9984 54.1928 54.1928 54.1928 54.1928 206.18 206.18 206.18 206.18 0.0 83.9984 0.0 83.9984 83.9984 54.1928 206.18 1 0 1 83792 SCD_9786 83.9984 83.9984 54.1928 54.1928 206.18 206.18 83.9984 54.1928 206.18 0 0 Exp 2,1(1) 1.8739502429962158 1.8739502429962158 1.8739502429962158 1.8739502429962158 0.0 1.8739502429962158 83.9984 83.9984 54.1928 54.1928 206.18 206.18 UP 1.0 0.0 0.0 GO:1903966 8 monounsaturated fatty acid biosynthetic process 2 2 1 1 1 1 1 1 68 1 2477 0.99928 0.053458 0.053458 50.0 83792 scd2 SCD_9786 83.9984 83.9984 83.9984 83.9984 54.1928 54.1928 54.1928 54.1928 206.18 206.18 206.18 206.18 0.0 83.9984 0.0 83.9984 83.9984 54.1928 206.18 1 0 1 83792 SCD_9786 83.9984 83.9984 54.1928 54.1928 206.18 206.18 83.9984 54.1928 206.18 0 0 Exp 2,1(1) 1.8739502429962158 1.8739502429962158 1.8739502429962158 1.8739502429962158 0.0 1.8739502429962158 83.9984 83.9984 54.1928 54.1928 206.18 206.18 UP 1.0 0.0 0.0 GO:0051365 6 cellular response to potassium ion starvation 3 3 2 2 2 2 2 2 67 1 2477 0.99998 0.0021326 0.0021326 66.67 362282;24516 pck1;jun PCK1_9439;JUN_8938 31.640435 31.640435 5.51457 36.94755261172856 47.10062668099614 29.783998898236714 20.01357 20.01357 1.34064 26.40751085524344 31.063427183516154 21.287506712097432 74.36055 74.36055 39.6721 49.05687644770102 94.88772053068485 39.54551386457601 0.0 5.51457 0.0 5.51457 5.51457;57.7663 1.34064;38.6865 39.6721;109.049 1 1 1 362282 PCK1_9439 5.51457 5.51457 1.34064 1.34064 39.6721 39.6721 5.51457 1.34064 39.6721 1 24516 JUN_8938 57.7663 57.7663 38.6865 38.6865 109.049 109.049 57.7663 38.6865 109.049 0 Exp 2,1(0.5);Hill,1(0.5) 1.8898128974042394 3.867947578430176 1.5230457782745361 2.3449018001556396 0.5811399662311278 1.933973789215088 -19.5662604 82.8471304 -16.585372799999995 56.6125128 6.371188000000004 142.34991200000002 CONFLICT 0.5 0.5 0.0 GO:0045655 8 regulation of monocyte differentiation 7 7 2 2 2 2 2 2 67 5 2473 0.99938 0.013912 0.013912 28.57 24516;29339 jun;apcs JUN_8938;APCS_8057 79.86015 79.86015 57.7663 31.245422315036738 83.89204634183479 30.72074282015977 48.59255 48.59255 38.6865 14.009270259546005 50.40030042634184 13.77402374025548 252.33499999999998 252.33499999999998 109.049 202.63700449819137 278.48319505138943 199.23428265012274 0.0 57.7663 0.0 57.7663 57.7663;101.954 38.6865;58.4986 109.049;395.621 0 2 0 2 24516;29339 JUN_8938;APCS_8057 79.86015 79.86015 31.245422315036738 48.59255 48.59255 14.009270259546005 252.33499999999998 252.33499999999998 202.63700449819137 57.7663;101.954 38.6865;58.4986 109.049;395.621 0 Exp 2,1(0.5);Linear,1(0.5) 1.5729519237961789 3.1475391387939453 1.5230457782745361 1.6244933605194092 0.07173427334032972 1.5737695693969727 36.556204000000015 123.164096 29.176692000000006 68.008408 -28.505559999999974 533.17556 DOWN 0.0 1.0 0.0 GO:0008285 6 negative regulation of cell population proliferation 190 199 10 10 8 8 7 7 62 192 2286 0.83356 0.29138 0.49043 3.52 29692;299923;24516;114851;24770;287562;282840 pla2g2a;ndrg1;jun;cdkn1a;ccl2;ccl12;atf5 PLA2G2A_32641;NDRG1_32364;JUN_8938;CDKN1A_8271;CCL2_8218;CCL12_8217;ATF5_8097 57.06758571428588 57.7663 1.16694E-12 36.03881817690576 62.30884817353109 34.38146896158353 35.691600000000165 38.6865 1.16694E-12 23.806708550462265 38.32718427896767 22.9203865464597 127.63501428571446 109.049 1.16694E-12 101.81504230303125 149.6691207732016 108.36685415864345 1.16694E-12;99.6641;57.7663;54.5478;64.0097;25.5289;97.9563 1.16694E-12;42.5546;38.6865;38.2987;41.1311;13.9582;75.2121 1.16694E-12;105.409;109.049;94.4701;132.851;336.862;114.804 0 7 0 7 29692;299923;24516;114851;24770;287562;282840 PLA2G2A_32641;NDRG1_32364;JUN_8938;CDKN1A_8271;CCL2_8218;CCL12_8217;ATF5_8097 57.06758571428588 57.7663 36.03881817690576 35.691600000000165 38.6865 23.806708550462265 127.63501428571446 109.049 101.81504230303125 1.16694E-12;99.6641;57.7663;54.5478;64.0097;25.5289;97.9563 1.16694E-12;42.5546;38.6865;38.2987;41.1311;13.9582;75.2121 1.16694E-12;105.409;109.049;94.4701;132.851;336.862;114.804 0 Exp 2,2(0.29);Exp 3,1(0.15);Hill,1(0.15);Linear,1(0.15);Poly 2,2(0.29) 1.7156454824571088 12.176018118858337 1.5226441621780396 2.385996103286743 0.3303778181782321 1.559963583946228 30.369655590871165 83.76551583770059 18.05534349933509 53.327856500665234 52.20937542109877 203.06065315033015 DOWN 0.0 1.0 0.0 GO:0015671 6 oxygen transport 4 7 3 3 3 3 3 3 66 4 2474 0.99998 6.1637E-4 6.1637E-4 42.86 287167;24440;360504 hba-a1;hbb;hba-a2 LOC287167_9118;HBB_8782;HBA2_32600 99.34576666666665 101.406 91.4283 7.114703863361853 97.89849738959413 7.535207239337187 73.80443333333334 82.0435 54.7263 16.573212682317582 70.0733716967638 17.450957830201915 174.412 130.247 115.953 89.16189567859135 194.48830538172717 93.873268788446 0.0 91.4283 0.0 91.4283 105.203;91.4283;101.406 82.0435;54.7263;84.6435 130.247;277.036;115.953 2 1 2 287167;360504 LOC287167_9118;HBA2_32600 103.3045 103.3045 2.684884448164576 83.3435 83.3435 1.8384776310843112 123.10000000000001 123.10000000000001 10.107384330280365 105.203;101.406 82.0435;84.6435 130.247;115.953 1 24440 HBB_8782 91.4283 91.4283 54.7263 54.7263 277.036 277.036 91.4283 54.7263 277.036 0 Linear,1(0.34);Poly 2,2(0.67) 1.735823928153788 5.209152460098267 1.6757243871688843 1.778118371963501 0.05375652792446753 1.7553097009658813 91.29472133286268 107.39681200047067 55.05007767852628 92.55878898814039 73.51581683587564 275.3081831641244 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0033327 4 Leydig cell differentiation 8 9 2 2 2 2 2 2 67 7 2471 0.99858 0.023028 0.023028 22.22 29680;58919 cyp11a1;ccnd1 CYP11A1_32785;CCND1_8224 35.99225 35.99225 28.2655 10.927274643066331 31.887805019305016 9.258098828911676 27.89745 27.89745 22.3101 7.901706147725311 24.929453020301402 6.694695504800808 51.1184 51.1184 38.3337 18.08029613087131 44.327175003113716 15.318473627073098 0.0 28.2655 0.0 28.2655 43.719;28.2655 33.4848;22.3101 63.9031;38.3337 2 0 2 29680;58919 CYP11A1_32785;CCND1_8224 35.99225 35.99225 10.927274643066331 27.89745 27.89745 7.901706147725311 51.1184 51.1184 18.08029613087131 43.719;28.2655 33.4848;22.3101 63.9031;38.3337 0 0 Exp 2,1(0.5);Linear,1(0.5) 1.993619257236558 4.020334482192993 1.752767562866211 2.2675669193267822 0.36401811590374067 2.0101672410964966 20.84782 51.13668 16.946244 38.848656 26.060387999999996 76.176412 UP 1.0 0.0 0.0 GO:0061024 5 membrane organization 110 116 3 3 3 3 3 3 66 113 2365 0.61433 0.61694 1.0 2.59 299923;286918;25649 ndrg1;mx2;apoa2 NDRG1_32364;MX2_9268;APOA2_33095 70.50253333333335 80.183 31.6605 35.020079660151154 69.97277076244012 35.20031779398564 38.8171 42.5546 23.5989 13.736247485758259 38.61940164862112 13.814946736123636 116.452 105.409 46.786 75.7932783497323 115.58308560003017 75.96107593512808 99.6641;31.6605;80.183 42.5546;23.5989;50.2978 105.409;46.786;197.161 1 2 1 25649 APOA2_33095 80.183 80.183 50.2978 50.2978 197.161 197.161 80.183 50.2978 197.161 2 299923;286918 NDRG1_32364;MX2_9268 65.6623 65.6623 48.0858067050975 33.076750000000004 33.076750000000004 13.403704012137817 76.0975 76.0975 41.452720833499015 99.6641;31.6605 42.5546;23.5989 105.409;46.786 0 Exp 2,1(0.34);Exp 3,1(0.34);Linear,1(0.34) 1.9978051015251839 6.1504446268081665 1.5226441621780396 2.6565301418304443 0.5710434698025015 1.9712703227996826 30.87358259242572 110.13148407424094 23.27307268022662 54.36112731977339 30.683831470354917 202.2201685296451 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:1901360 4 organic cyclic compound metabolic process 507 567 16 15 14 14 12 12 57 555 1923 0.20285 0.87326 0.38018 2.12 360847;360243;78968;287877;362282;114519;293502;24516;24450;25086;29680;25649 ube2t;top2a;srebf1;pycr1;pck1;nfil3;kif22;jun;hmgcs2;cyp2e1;cyp11a1;apoa2 UBE2T_10125;TOP2A_10059;SREBF1_32750;PYCR1_9631;PCK1_9439;NFIL3_9304;KIF22_8963;JUN_8938;HMGCS2_8812;CYP2E1_8421;CYP11A1_32785;APOA2_33095 33.705555833333335 31.8567 5.51457 23.685193374663974 42.289059374476686 25.49600924327555 22.543382500000003 25.090000000000003 1.34064 15.861519329908944 28.440079314436254 16.17826856334502 63.28530833333334 43.5987 18.2059 51.05148477773925 82.30209278902117 63.768665570746705 10.9914;13.8391;11.2357;54.7122;5.51457;33.1149;13.2391;57.7663;30.5985;49.5529;43.719;80.183 7.86591;9.31624;4.94421;38.3856;1.34064;25.603;9.02099;38.6865;24.577;26.9979;33.4848;50.2978 18.2059;27.6952;24.5771;94.9303;39.6721;46.6318;25.4349;109.049;40.5656;71.5977;63.9031;197.161 10 2 10 360847;360243;78968;287877;362282;293502;24450;25086;29680;25649 UBE2T_10125;TOP2A_10059;SREBF1_32750;PYCR1_9631;PCK1_9439;KIF22_8963;HMGCS2_8812;CYP2E1_8421;CYP11A1_32785;APOA2_33095 31.358546999999998 22.2188 24.802597194520693 20.623109 16.946620000000003 16.534911702115114 60.374289999999995 40.11885 53.967479905329206 10.9914;13.8391;11.2357;54.7122;5.51457;13.2391;30.5985;49.5529;43.719;80.183 7.86591;9.31624;4.94421;38.3856;1.34064;9.02099;24.577;26.9979;33.4848;50.2978 18.2059;27.6952;24.5771;94.9303;39.6721;25.4349;40.5656;71.5977;63.9031;197.161 2 114519;24516 NFIL3_9304;JUN_8938 45.4406 45.4406 17.431172105742025 32.14475 32.14475 9.251431571654184 77.8404 77.8404 44.13562538267699 33.1149;57.7663 25.603;38.6865 46.6318;109.049 0 Exp 2,3(0.25);Hill,2(0.17);Linear,3(0.25);Poly 2,4(0.34) 2.1339935571414723 26.391967058181763 1.5230457782745361 3.3687045574188232 0.5788143432962605 2.0874189138412476 20.30439611807616 47.106715548590515 13.568883094218208 31.517881905781792 34.400211623954654 92.17040504271202 UP 0.8333333333333334 0.16666666666666666 0.0 GO:0048519 4 negative regulation of biological process 1024 1094 41 41 35 38 33 33 36 1061 1417 0.82967 0.2394 0.45978 3.02 29142;360243;78968;84386;287877;29692;360918;316351;114519;299923;314654;286918;290350;100911740;304477;24516;85430;24367;116663;299691;84032;306575;114851;58919;24770;287562;282840;289054;25612;29657;25649;29339;81639 vnn1;top2a;srebf1;slpi;pycr1;pla2g2a;pf4;npas2;nfil3;ndrg1;myo1f;mx2;loxl2;mrln;kntc1;jun;herpud1;fgg;dusp6;cry1;col3a1;ckap2;cdkn1a;ccnd1;ccl2;ccl12;atf5;aspm;asns;arntl;apoa2;apcs;alox15 VNN1_10157;TOP2A_10059;SREBF1_32750;SLPI_9890;PYCR1_9631;PLA2G2A_32641;PF4_32963;NPAS2_9350;NFIL3_9304;NDRG1_32364;MYO1F_32715;MX2_9268;LOXL2_9150;LOC100911740_32571;KNTC1_8976;JUN_8938;HERPUD1_8795;FGG_8639;DUSP6_8506;CRY1_8386;COL3A1_8354;CKAP2_8324;CDKN1A_8271;CCND1_8224;CCL2_8218;CCL12_8217;ATF5_8097;ASPM_8092;ASNS_8091;ARNTL_8086;APOA2_33095;APCS_8057;ALOX15_8036 54.29957242424245 54.7122 1.16694E-12 32.70818085413081 56.652351871027335 30.698969237930267 35.05075666666671 38.2987 1.16694E-12 20.676519357676323 36.80536544719157 20.07448576225032 113.7794151515152 99.4319 1.16694E-12 97.91402283916008 122.53052886892381 99.71297793793488 20.8684;13.8391;11.2357;56.5193;54.7122;1.16694E-12;105.82;58.2312;33.1149;99.6641;91.9576;31.6605;65.4434;91.003;7.89839;57.7663;53.893;93.1824;45.5478;37.2548;57.8774;12.1218;54.5478;28.2655;64.0097;25.5289;97.9563;10.3235;85.6642;38.2177;80.183;101.954;105.624 17.1194;9.31624;4.94421;39.3315;38.3856;1.16694E-12;53.8521;35.795;25.603;42.5546;61.1322;23.5989;43.7615;54.5666;3.83458;38.6865;37.9512;51.338;33.3115;21.8798;39.4215;8.47044;38.2987;22.3101;41.1311;13.9582;75.2121;7.4611;53.6991;27.1236;50.2978;58.4986;83.8302 26.5474;27.6952;24.5771;100.108;94.9303;1.16694E-12;109.875;99.4319;46.6318;105.409;110.707;46.786;129.393;273.335;12.5679;109.049;92.6554;327.378;71.7388;73.8251;106.603;21.3803;94.4701;38.3337;132.851;336.862;114.804;16.8623;224.488;63.2034;197.161;395.621;129.44 13 20 13 29142;360243;78968;287877;314654;304477;85430;306575;58919;289054;25612;25649;81639 VNN1_10157;TOP2A_10059;SREBF1_32750;PYCR1_9631;MYO1F_32715;KNTC1_8976;HERPUD1_8795;CKAP2_8324;CCND1_8224;ASPM_8092;ASNS_8091;APOA2_33095;ALOX15_8036 44.352799230769236 28.2655 36.02435011161211 30.673243846153845 22.3101 25.66613850346521 78.25735384615385 38.3337 71.12476559300114 20.8684;13.8391;11.2357;54.7122;91.9576;7.89839;53.893;12.1218;28.2655;10.3235;85.6642;80.183;105.624 17.1194;9.31624;4.94421;38.3856;61.1322;3.83458;37.9512;8.47044;22.3101;7.4611;53.6991;50.2978;83.8302 26.5474;27.6952;24.5771;94.9303;110.707;12.5679;92.6554;21.3803;38.3337;16.8623;224.488;197.161;129.44 20 84386;29692;360918;316351;114519;299923;286918;290350;100911740;24516;24367;116663;299691;84032;114851;24770;287562;282840;29657;29339 SLPI_9890;PLA2G2A_32641;PF4_32963;NPAS2_9350;NFIL3_9304;NDRG1_32364;MX2_9268;LOXL2_9150;LOC100911740_32571;JUN_8938;FGG_8639;DUSP6_8506;CRY1_8386;COL3A1_8354;CDKN1A_8271;CCL2_8218;CCL12_8217;ATF5_8097;ARNTL_8086;APCS_8057 60.76497500000005 57.82185 29.50390781588572 37.89614000000005 39.009 16.803108003718453 136.86875500000005 106.006 107.365149010985 56.5193;1.16694E-12;105.82;58.2312;33.1149;99.6641;31.6605;65.4434;91.003;57.7663;93.1824;45.5478;37.2548;57.8774;54.5478;64.0097;25.5289;97.9563;38.2177;101.954 39.3315;1.16694E-12;53.8521;35.795;25.603;42.5546;23.5989;43.7615;54.5666;38.6865;51.338;33.3115;21.8798;39.4215;38.2987;41.1311;13.9582;75.2121;27.1236;58.4986 100.108;1.16694E-12;109.875;99.4319;46.6318;105.409;46.786;129.393;273.335;109.049;327.378;71.7388;73.8251;106.603;94.4701;132.851;336.862;114.804;63.2034;395.621 0 Exp 2,8(0.25);Exp 3,2(0.07);Exp 5,1(0.04);Hill,2(0.07);Linear,11(0.34);Poly 2,7(0.22);Power,2(0.07) 1.9553892079020807 68.03130769729614 1.5226441621780396 4.897102355957031 0.82244674200631 1.7373461723327637 43.139796055064686 65.4593487934202 27.996089421377164 42.10542391195624 80.37191373268922 147.18691657034114 DOWN 0.3939393939393939 0.6060606060606061 0.0 GO:0018158 6 protein oxidation 8 8 2 2 2 2 2 2 67 6 2472 0.99903 0.018227 0.018227 25.0 290350;25649 loxl2;apoa2 LOXL2_9150;APOA2_33095 72.8132 72.8132 65.4434 10.42247111197741 73.71518965628012 10.344115882951327 47.029650000000004 47.029650000000004 43.7615 4.621862053869518 47.42963880501124 4.58711529795492 163.277 163.277 129.393 47.91921234745006 167.42406199807257 47.558959887368296 0.0 65.4434 0.0 65.4434 65.4434;80.183 43.7615;50.2978 129.393;197.161 1 1 1 25649 APOA2_33095 80.183 80.183 50.2978 50.2978 197.161 197.161 80.183 50.2978 197.161 1 290350 LOXL2_9150 65.4434 65.4434 43.7615 43.7615 129.393 129.393 65.4434 43.7615 129.393 0 Linear,2(1) 1.8506158299196516 3.7086164951324463 1.7373461723327637 1.9712703227996826 0.16540935307846066 1.8543082475662231 58.368391999999986 87.258008 40.624076 53.435224000000005 96.86436 229.68963999999997 CONFLICT 0.5 0.5 0.0 GO:0045087 5 innate immune response 79 87 4 4 4 4 4 4 65 83 2395 0.91573 0.20799 0.29592 4.6 29142;84386;286918;29339 vnn1;slpi;mx2;apcs VNN1_10157;SLPI_9890;MX2_9268;APCS_8057 52.750550000000004 44.0899 20.8684 36.03907447058908 58.173454072164944 34.681499554158606 34.637100000000004 31.4652 17.1194 18.440175759646824 37.666805920471276 17.395009149309775 142.2656 73.447 26.5474 171.72970794664505 160.5350246244477 174.08398523379415 20.8684;56.5193;31.6605;101.954 17.1194;39.3315;23.5989;58.4986 26.5474;100.108;46.786;395.621 1 3 1 29142 VNN1_10157 20.8684 20.8684 17.1194 17.1194 26.5474 26.5474 20.8684 17.1194 26.5474 3 84386;286918;29339 SLPI_9890;MX2_9268;APCS_8057 63.37793333333334 56.5193 35.64512132064262 40.476333333333336 39.3315 17.47799323559009 180.83833333333334 100.108 187.90823384389876 56.5193;31.6605;101.954 39.3315;23.5989;58.4986 100.108;46.786;395.621 0 Exp 2,2(0.5);Linear,2(0.5) 2.060991168472956 8.50560438632965 1.5823365449905396 2.6565301418304443 0.6041657242763645 2.1333688497543335 17.43225701882269 88.06884298117731 16.5657277555461 52.708472244453894 -26.02951378771212 310.56071378771213 DOWN 0.25 0.75 0.0 GO:0010556 6 regulation of macromolecule biosynthetic process 567 609 24 24 22 23 21 21 48 588 1890 0.92087 0.12725 0.1993 3.45 360243;24825;78968;360918;362282;316351;114519;366960;290350;24516;24440;24309;299691;498709;306575;114851;58919;24770;282840;29657;25649 top2a;tf;srebf1;pf4;pck1;npas2;nfil3;maff;loxl2;jun;hbb;dbp;cry1;cks2;ckap2;cdkn1a;ccnd1;ccl2;atf5;arntl;apoa2 TOP2A_10059;TF_10003;SREBF1_32750;PF4_32963;PCK1_9439;NPAS2_9350;NFIL3_9304;MAFF_9172;LOXL2_9150;JUN_8938;HBB_8782;DBP_8439;CRY1_8386;CKS2_8325;CKAP2_8324;CDKN1A_8271;CCND1_8224;CCL2_8218;ATF5_8097;ARNTL_8086;APOA2_33095 49.026022380952384 51.412 5.51457 29.345271174027662 54.630749806834615 24.96508910214651 32.36673 36.6131 1.34064 18.94304047687963 36.87008902963039 17.264368211569575 89.46553809523812 86.0232 21.3803 62.10227845459031 98.75465820772249 54.70487048085684 13.8391;51.412;11.2357;105.82;5.51457;58.2312;33.1149;58.0695;65.4434;57.7663;91.4283;50.6952;37.2548;14.4197;12.1218;54.5478;28.2655;64.0097;97.9563;38.2177;80.183 9.31624;36.6131;4.94421;53.8521;1.34064;35.795;25.603;40.1293;43.7615;38.6865;54.7263;40.5862;21.8798;9.6236;8.47044;38.2987;22.3101;41.1311;75.2121;27.1236;50.2978 27.6952;86.0232;24.5771;109.875;39.6721;99.4319;46.6318;104.733;129.393;109.049;277.036;59.5346;73.8251;29.0958;21.3803;94.4701;38.3337;132.851;114.804;63.2034;197.161 9 12 9 360243;24825;78968;362282;366960;498709;306575;58919;25649 TOP2A_10059;TF_10003;SREBF1_32750;PCK1_9439;MAFF_9172;CKS2_8325;CKAP2_8324;CCND1_8224;APOA2_33095 30.562318888888893 14.4197 26.315519279551772 20.33838111111111 9.6236 17.7940939204125 63.185711111111104 38.3337 58.12447223197912 13.8391;51.412;11.2357;5.51457;58.0695;14.4197;12.1218;28.2655;80.183 9.31624;36.6131;4.94421;1.34064;40.1293;9.6236;8.47044;22.3101;50.2978 27.6952;86.0232;24.5771;39.6721;104.733;29.0958;21.3803;38.3337;197.161 12 360918;316351;114519;290350;24516;24440;24309;299691;114851;24770;282840;29657 PF4_32963;NPAS2_9350;NFIL3_9304;LOXL2_9150;JUN_8938;HBB_8782;DBP_8439;CRY1_8386;CDKN1A_8271;CCL2_8218;ATF5_8097;ARNTL_8086 62.873799999999996 57.99875 23.957424179155836 41.387991666666665 39.63635 14.662905841703129 109.17540833333334 104.24045000000001 59.718136450700385 105.82;58.2312;33.1149;65.4434;57.7663;91.4283;50.6952;37.2548;54.5478;64.0097;97.9563;38.2177 53.8521;35.795;25.603;43.7615;38.6865;54.7263;40.5862;21.8798;38.2987;41.1311;75.2121;27.1236 109.875;99.4319;46.6318;129.393;109.049;277.036;59.5346;73.8251;94.4701;132.851;114.804;63.2034 0 Exp 2,3(0.15);Exp 3,1(0.05);Hill,2(0.1);Linear,8(0.39);Poly 2,5(0.24);Power,2(0.1) 2.255641771901386 51.495582699775696 1.5230457782745361 5.737884044647217 1.2001408098116537 1.9712703227996826 36.47484257951355 61.577202182391204 24.264657758061432 40.468802241938576 62.9039548561488 116.0271213343274 CONFLICT 0.42857142857142855 0.5714285714285714 0.0 GO:0051716 3 cellular response to stimulus 785 838 35 34 32 32 30 30 39 808 1670 0.9768 0.040747 0.068455 3.58 360847;360243;24825;78968;24777;287877;360918;362282;338475;114519;24587;299923;286918;293502;24516;79438;24450;85430;24367;361921;29680;299691;84032;114851;58919;24770;287562;25612;29657;81639 ube2t;top2a;tf;srebf1;slc10a1;pycr1;pf4;pck1;nrep;nfil3;nefh;ndrg1;mx2;kif22;jun;igfals;hmgcs2;herpud1;fgg;ect2;cyp11a1;cry1;col3a1;cdkn1a;ccnd1;ccl2;ccl12;asns;arntl;alox15 UBE2T_10125;TOP2A_10059;TF_10003;SREBF1_32750;SLC10A1_9832;PYCR1_9631;PF4_32963;PCK1_9439;NREP_9364;NFIL3_9304;NEFH_33218;NDRG1_32364;MX2_9268;KIF22_8963;JUN_8938;IGFALS_8880;HMGCS2_8812;HERPUD1_8795;FGG_8639;ECT2_8523;CYP11A1_32785;CRY1_8386;COL3A1_8354;CDKN1A_8271;CCND1_8224;CCL2_8218;CCL12_8217;ASNS_8091;ARNTL_8086;ALOX15_8036 47.20933633333333 40.96835 5.51457 30.234849489600855 49.51289580564465 28.879017324385746 30.331932999999996 30.759050000000002 1.34064 18.392984007036425 31.66978075033455 17.706000401893615 98.89770000000001 79.92415 11.4863 85.72934098400053 109.54803305829583 90.80334546716918 10.9914;13.8391;51.412;11.2357;7.96762;54.7122;105.82;5.51457;36.861;33.1149;79.3182;99.6641;31.6605;13.2391;57.7663;70.3663;30.5985;53.893;93.1824;14.4142;43.719;37.2548;57.8774;54.5478;28.2655;64.0097;25.5289;85.6642;38.2177;105.624 7.86591;9.31624;36.6131;4.94421;6.07525;38.3856;53.8521;1.34064;28.0333;25.603;39.4261;42.5546;23.5989;9.02099;38.6865;46.0459;24.577;37.9512;51.338;9.59235;33.4848;21.8798;39.4215;38.2987;22.3101;41.1311;13.9582;53.6991;27.1236;83.8302 18.2059;27.6952;86.0232;24.5771;11.4863;94.9303;109.875;39.6721;53.5645;46.6318;264.141;105.409;46.786;25.4349;109.049;148.796;40.5656;92.6554;327.378;30.0753;63.9031;73.8251;106.603;94.4701;38.3337;132.851;336.862;224.488;63.2034;129.44 14 16 14 360847;360243;24825;78968;287877;362282;293502;24450;85430;361921;29680;58919;25612;81639 UBE2T_10125;TOP2A_10059;TF_10003;SREBF1_32750;PYCR1_9631;PCK1_9439;KIF22_8963;HMGCS2_8812;HERPUD1_8795;ECT2_8523;CYP11A1_32785;CCND1_8224;ASNS_8091;ALOX15_8036 37.36589071428572 29.432000000000002 30.3663592949218 26.63796 23.443550000000002 22.875129438809235 66.85712857142858 40.11885 56.56486095658313 10.9914;13.8391;51.412;11.2357;54.7122;5.51457;13.2391;30.5985;53.893;14.4142;43.719;28.2655;85.6642;105.624 7.86591;9.31624;36.6131;4.94421;38.3856;1.34064;9.02099;24.577;37.9512;9.59235;33.4848;22.3101;53.6991;83.8302 18.2059;27.6952;86.0232;24.5771;94.9303;39.6721;25.4349;40.5656;92.6554;30.0753;63.9031;38.3337;224.488;129.44 16 24777;360918;338475;114519;24587;299923;286918;24516;79438;24367;299691;84032;114851;24770;287562;29657 SLC10A1_9832;PF4_32963;NREP_9364;NFIL3_9304;NEFH_33218;NDRG1_32364;MX2_9268;JUN_8938;IGFALS_8880;FGG_8639;CRY1_8386;COL3A1_8354;CDKN1A_8271;CCL2_8218;CCL12_8217;ARNTL_8086 55.82235125000001 56.15705 28.259842142623942 33.564159375 38.492599999999996 13.291679457681015 126.9332 106.006 98.18122312571451 7.96762;105.82;36.861;33.1149;79.3182;99.6641;31.6605;57.7663;70.3663;93.1824;37.2548;57.8774;54.5478;64.0097;25.5289;38.2177 6.07525;53.8521;28.0333;25.603;39.4261;42.5546;23.5989;38.6865;46.0459;51.338;21.8798;39.4215;38.2987;41.1311;13.9582;27.1236 11.4863;109.875;53.5645;46.6318;264.141;105.409;46.786;109.049;148.796;327.378;73.8251;106.603;94.4701;132.851;336.862;63.2034 0 Exp 2,10(0.34);Exp 3,2(0.07);Hill,2(0.07);Linear,8(0.27);Poly 2,7(0.24);Power,1(0.04) 1.9628432614361835 61.51154589653015 1.5226441621780396 4.897102355957031 0.7204415543725203 1.7734381556510925 36.38993439569107 58.02873827097558 23.750088202882733 36.91377779711726 68.2198493206337 129.5755506793663 CONFLICT 0.4666666666666667 0.5333333333333333 0.0 GO:0006812 6 cation transport 135 141 5 5 5 4 4 4 65 137 2341 0.66573 0.53752 0.79104 2.84 24825;29503;24777;287562 tf;slc22a2;slc10a1;ccl12 TF_10003;SLC22A2_9845;SLC10A1_9832;CCL12_8217 41.682605 38.47045 7.96762 32.163470630205616 31.538800785806117 23.350710722967058 25.7517625 25.28565 6.07525 18.87628118598289 19.590676310105422 15.089787439334042 134.112625 94.05109999999999 11.4863 140.81106795202274 194.90470149138596 164.89299729809468 51.412;81.8219;7.96762;25.5289 36.6131;46.3605;6.07525;13.9582 86.0232;102.079;11.4863;336.862 2 2 2 24825;29503 TF_10003;SLC22A2_9845 66.61695 66.61695 21.50304650520477 41.4868 41.4868 6.892452638937774 94.05109999999999 94.05109999999999 11.35316505737502 51.412;81.8219 36.6131;46.3605 86.0232;102.079 2 24777;287562 SLC10A1_9832;CCL12_8217 16.748260000000002 16.748260000000002 12.417700174315687 10.016725 10.016725 5.574087400754495 174.17415 174.17415 230.07536390331975 7.96762;25.5289 6.07525;13.9582 11.4863;336.862 0 Linear,1(0.25);Poly 2,3(0.75) 1.88370293441275 7.661019802093506 1.5314651727676392 2.4529356956481934 0.4097703227972689 1.8383094668388367 10.162403782398478 73.2028062176015 7.253006937736764 44.25051806226323 -3.8822215929822903 272.1074715929823 CONFLICT 0.5 0.5 0.0 GO:0071276 7 cellular response to cadmium ion 18 20 2 2 2 2 2 2 67 18 2460 0.98441 0.1005 0.1005 10.0 24516;29680 jun;cyp11a1 JUN_8938;CYP11A1_32785 50.74265 50.74265 43.719 9.93294108736183 54.12031756999035 8.708963326267478 36.08565 36.08565 33.4848 3.6781573436980812 37.3363966487381 3.2249197023090654 86.47605 86.47605 63.9031 31.922972032769785 97.33136328782237 27.98929242141462 0.0 43.719 1.0 57.7663 57.7663;43.719 38.6865;33.4848 109.049;63.9031 1 1 1 29680 CYP11A1_32785 43.719 43.719 33.4848 33.4848 63.9031 63.9031 43.719 33.4848 63.9031 1 24516 JUN_8938 57.7663 57.7663 38.6865 38.6865 109.049 109.049 57.7663 38.6865 109.049 0 Exp 2,2(1) 1.6338743026683327 3.275813341140747 1.5230457782745361 1.752767562866211 0.1624378316710486 1.6379066705703735 36.976296 64.50900399999999 30.987984 41.183316000000005 42.233067999999996 130.719032 CONFLICT 0.5 0.5 0.0 GO:1902903 6 regulation of supramolecular fiber organization 89 94 2 2 2 2 2 2 67 92 2386 0.52751 0.73208 1.0 2.13 306575;81639 ckap2;alox15 CKAP2_8324;ALOX15_8036 58.8729 58.8729 12.1218 66.11603967586079 89.00729688350235 50.54865924389224 46.15032 46.15032 8.47044 53.287397324590735 70.43767277764037 40.74059037050997 75.41015 75.41015 21.3803 76.40974664298395 110.23621705416771 58.4186570294305 12.1218;105.624 8.47044;83.8302 21.3803;129.44 2 0 2 306575;81639 CKAP2_8324;ALOX15_8036 58.8729 58.8729 66.11603967586079 46.15032 46.15032 53.287397324590735 75.41015 75.41015 76.40974664298395 12.1218;105.624 8.47044;83.8302 21.3803;129.44 0 0 Poly 2,2(1) 1.9217076526410728 3.874759316444397 1.6914535760879517 2.1833057403564453 0.34779200069553157 1.9373796582221985 -32.75925599999997 150.50505599999997 -27.70224479999999 120.0028848 -30.488355999999996 181.30865599999998 UP 1.0 0.0 0.0 GO:0006805 4 xenobiotic metabolic process 43 62 3 3 3 3 3 3 66 59 2419 0.91495 0.23506 0.23506 4.84 25086;499353;29680 cyp2e1;cyp2c24;cyp11a1 CYP2E1_8421;CYP2C24_32875;CYP11A1_32785 34.61233333333333 43.719 10.5651 21.028805732692792 27.951431063480666 22.52464543825555 22.706363333333332 26.9979 7.63639 13.44797531612225 18.081691722900214 13.720146335661928 50.8493 63.9031 17.0471 29.525298659285397 41.46388195056917 31.611348171869793 49.5529;10.5651;43.719 26.9979;7.63639;33.4848 71.5977;17.0471;63.9031 2 1 2 25086;29680 CYP2E1_8421;CYP11A1_32785 46.63595 46.63595 4.125190250764143 30.24135 30.24135 4.586930978879031 67.7504 67.7504 5.440903838518165 49.5529;43.719 26.9979;33.4848 71.5977;63.9031 1 499353 CYP2C24_32875 10.5651 10.5651 7.63639 7.63639 17.0471 17.0471 10.5651 7.63639 17.0471 0 Exp 2,1(0.34);Poly 2,2(0.67) 2.0682400050447476 6.246950149536133 1.752767562866211 2.2906150817871094 0.2886975989902603 2.2035675048828125 10.815999498340528 58.40866716832613 7.488546682448829 37.92417998421784 17.43827930746866 84.26032069253134 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0007167 6 enzyme linked receptor protein signaling pathway 141 148 4 4 4 4 4 4 65 144 2334 0.62714 0.5769 1.0 2.7 78968;24516;84032;24770 srebf1;jun;col3a1;ccl2 SREBF1_32750;JUN_8938;COL3A1_8354;CCL2_8218 47.722274999999996 57.82185 11.2357 24.498703165184768 51.27150804064115 21.340154074340088 31.0458275 39.054 4.94421 17.431187792718696 33.53777571428571 15.133770232513818 93.270025 107.826 24.5771 47.30086609991934 100.02693915214154 41.49797717722612 11.2357;57.7663;57.8774;64.0097 4.94421;38.6865;39.4215;41.1311 24.5771;109.049;106.603;132.851 1 3 1 78968 SREBF1_32750 11.2357 11.2357 4.94421 4.94421 24.5771 24.5771 11.2357 4.94421 24.5771 3 24516;84032;24770 JUN_8938;COL3A1_8354;CCL2_8218 59.88446666666666 57.8774 3.572988713015347 39.74636666666667 39.4215 1.2542611583451135 116.16766666666666 109.049 14.49985990736934 57.7663;57.8774;64.0097 38.6865;39.4215;41.1311 109.049;106.603;132.851 0 Exp 2,3(0.75);Hill,1(0.25) 1.8124412486959864 7.529906153678894 1.5230457782745361 2.857419490814209 0.6505298842488964 1.5747204422950745 23.71354589811894 71.73100410188106 13.963263463135686 48.128391536864314 46.91517622207904 139.62487377792098 DOWN 0.25 0.75 0.0 GO:0043603 5 cellular amide metabolic process 114 134 5 4 5 4 4 4 65 130 2348 0.70382 0.4965 0.7824 2.99 29142;24450;24440;25612 vnn1;hmgcs2;hbb;asns VNN1_10157;HMGCS2_8812;HBB_8782;ASNS_8091 57.139849999999996 58.13135 20.8684 36.55770639801317 56.03023992444885 34.64095706348069 37.53045 39.13805 17.1194 19.50662561840634 37.37256341342581 18.363691571745598 142.15925 132.5268 26.5474 127.3540083754336 133.48088090165965 120.22687321792894 20.8684;30.5985;91.4283;85.6642 17.1194;24.577;54.7263;53.6991 26.5474;40.5656;277.036;224.488 3 1 3 29142;24450;25612 VNN1_10157;HMGCS2_8812;ASNS_8091 45.710366666666665 30.5985 34.941383916830375 31.7985 24.577 19.329541114832498 97.20033333333333 40.5656 110.45696015595094 20.8684;30.5985;85.6642 17.1194;24.577;53.6991 26.5474;40.5656;224.488 1 24440 HBB_8782 91.4283 91.4283 54.7263 54.7263 277.036 277.036 91.4283 54.7263 277.036 0 Exp 2,3(0.75);Linear,1(0.25) 2.234610216117807 9.362201929092407 1.5959433317184448 3.3687045574188232 0.8256445090919848 2.1987770199775696 21.313297729947095 92.9664022700529 18.41395689396178 56.64694310603822 17.35232179207513 266.9661782079249 UP 0.75 0.25 0.0 GO:0006468 7 protein phosphorylation 190 202 6 6 5 6 5 5 64 197 2281 0.52937 0.65086 1.0 2.48 24825;299691;58919;24770;287562 tf;cry1;ccnd1;ccl2;ccl12 TF_10003;CRY1_8386;CCND1_8224;CCL2_8218;CCL12_8217 41.29418 37.2548 25.5289 16.2247671572507 36.22235574499159 13.572004736419593 27.17846 22.3101 13.9582 11.294252921862514 23.253603114582344 9.971551994274153 133.579 86.0232 38.3337 118.562491880801 153.8968099565038 137.98973510370345 51.412;37.2548;28.2655;64.0097;25.5289 36.6131;21.8798;22.3101;41.1311;13.9582 86.0232;73.8251;38.3337;132.851;336.862 2 3 2 24825;58919 TF_10003;CCND1_8224 39.83875 39.83875 16.367047110734426 29.4616 29.4616 10.113748291311188 62.17845 62.17845 33.72156884139585 51.412;28.2655 36.6131;22.3101 86.0232;38.3337 3 299691;24770;287562 CRY1_8386;CCL2_8218;CCL12_8217 42.264466666666664 37.2548 19.723477437899575 25.656366666666667 21.8798 13.974564946478061 181.17936666666665 132.851 138.0174842507403 37.2548;64.0097;25.5289 21.8798;41.1311;13.9582 73.8251;132.851;336.862 0 Exp 2,2(0.4);Linear,2(0.4);Poly 2,1(0.2) 1.8246600210741897 9.226133823394775 1.5314651727676392 2.2675669193267822 0.3098285668521597 1.8622472286224365 27.072544545174342 55.515815454825656 17.278610822962797 37.078309177037205 29.65439376052275 237.50360623947728 DOWN 0.4 0.6 0.0 GO:0045604 6 regulation of epidermal cell differentiation 11 11 1 1 1 1 1 1 68 10 2468 0.96602 0.26119 0.26119 9.09 366960 maff MAFF_9172 58.0695 58.0695 58.0695 58.0695 40.1293 40.1293 40.1293 40.1293 104.733 104.733 104.733 104.733 0.0 58.0695 58.0695 40.1293 104.733 1 0 1 366960 MAFF_9172 58.0695 58.0695 40.1293 40.1293 104.733 104.733 58.0695 40.1293 104.733 0 0 Linear,1(1) 1.8216042518615723 1.8216042518615723 1.8216042518615723 1.8216042518615723 0.0 1.8216042518615723 58.0695 58.0695 40.1293 40.1293 104.733 104.733 UP 1.0 0.0 0.0 GO:0070542 5 response to fatty acid 60 63 7 6 5 6 4 4 65 59 2419 0.97372 0.08903 0.08903 6.35 78968;83792;24450;24770 srebf1;scd2;hmgcs2;ccl2 SREBF1_32750;SCD_9786;HMGCS2_8812;CCL2_8218 47.460575 47.3041 11.2357 32.687700725030616 51.12502800913072 31.213193493877647 31.2112775 32.85405 4.94421 21.295740793611564 34.536551707693256 19.18475905196185 101.043425 86.70830000000001 24.5771 84.79403950327229 107.62831743475847 87.8748739266783 2.5 74.00405 11.2357;83.9984;30.5985;64.0097 4.94421;54.1928;24.577;41.1311 24.5771;206.18;40.5656;132.851 3 1 3 78968;83792;24450 SREBF1_32750;SCD_9786;HMGCS2_8812 41.9442 30.5985 37.68482863421299 27.90467 24.577 24.792356583606566 90.4409 40.5656 100.55129280456815 11.2357;83.9984;30.5985 4.94421;54.1928;24.577 24.5771;206.18;40.5656 1 24770 CCL2_8218 64.0097 64.0097 41.1311 41.1311 132.851 132.851 64.0097 41.1311 132.851 0 Exp 2,3(0.75);Hill,1(0.25) 2.303177242232276 9.660037875175476 1.559963583946228 3.3687045574188232 0.8424388208582346 2.3656848669052124 15.426628289469996 79.49452171053 10.34145152226067 52.08110347773933 17.945266286793156 184.14158371320684 UP 0.75 0.25 0.0 GO:0044774 8 mitotic DNA integrity checkpoint 17 18 3 3 3 3 3 3 66 15 2463 0.99887 0.011601 0.011601 16.67 360243;114851;58919 top2a;cdkn1a;ccnd1 TOP2A_10059;CDKN1A_8271;CCND1_8224 32.21746666666667 28.2655 13.8391 20.640084649131982 40.316040323364945 18.780869801645867 23.308346666666665 22.3101 9.31624 14.516994152321384 29.18384160102115 12.457942709040111 53.49966666666666 38.3337 27.6952 35.87794205641308 66.25893433625092 36.01649597064267 0.0 13.8391 0.5 21.0523 13.8391;54.5478;28.2655 9.31624;38.2987;22.3101 27.6952;94.4701;38.3337 2 1 2 360243;58919 TOP2A_10059;CCND1_8224 21.0523 21.0523 10.201005268109613 15.81317 15.81317 9.188046519788632 33.01445 33.01445 7.522555491653104 13.8391;28.2655 9.31624;22.3101 27.6952;38.3337 1 114851 CDKN1A_8271 54.5478 54.5478 38.2987 38.2987 94.4701 94.4701 54.5478 38.2987 94.4701 0 Linear,2(0.67);Poly 2,1(0.34) 1.9265247905644514 5.826496601104736 1.6645443439483643 2.2675669193267822 0.3043374228421131 1.8943853378295898 8.861012147251571 55.57392118608176 6.880821322599395 39.735872010733935 12.89995323835651 94.09938009497682 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0045769 7 negative regulation of asymmetric cell division 1 1 1 1 1 1 1 1 68 0 2478 1.0 0.027091 0.027091 100.0 289054 aspm ASPM_8092 10.3235 10.3235 10.3235 10.3235 7.4611 7.4611 7.4611 7.4611 16.8623 16.8623 16.8623 16.8623 0.0 10.3235 0.0 10.3235 10.3235 7.4611 16.8623 1 0 1 289054 ASPM_8092 10.3235 10.3235 7.4611 7.4611 16.8623 16.8623 10.3235 7.4611 16.8623 0 0 Poly 2,1(1) 1.5452834367752075 1.5452834367752075 1.5452834367752075 1.5452834367752075 0.0 1.5452834367752075 10.3235 10.3235 7.4611 7.4611 16.8623 16.8623 UP 1.0 0.0 0.0 GO:0051251 7 positive regulation of lymphocyte activation 82 87 3 3 3 3 3 3 66 84 2394 0.79201 0.42179 0.50972 3.45 29142;114851;24770 vnn1;cdkn1a;ccl2 VNN1_10157;CDKN1A_8271;CCL2_8218 46.475300000000004 54.5478 20.8684 22.675248259059895 50.7846103746609 17.169621770387273 32.18306666666667 38.2987 17.1194 13.12216302761604 35.2910264462204 10.147026052982929 84.62283333333333 94.4701 26.5474 53.831592386286864 90.84968370115114 40.09801498212321 20.8684;54.5478;64.0097 17.1194;38.2987;41.1311 26.5474;94.4701;132.851 1 2 1 29142 VNN1_10157 20.8684 20.8684 17.1194 17.1194 26.5474 26.5474 20.8684 17.1194 26.5474 2 114851;24770 CDKN1A_8271;CCL2_8218 59.27875 59.27875 6.690573652908962 39.7149 39.7149 2.0028092470327894 113.66055 113.66055 27.139394658042768 54.5478;64.0097 38.2987;41.1311 94.4701;132.851 0 Exp 2,2(0.67);Linear,1(0.34) 1.9001779255570077 5.86675226688385 1.559963583946228 2.642244338989258 0.5969598043980988 1.6645443439483643 20.815841054832713 72.13475894516728 17.333941328231887 47.03219200510145 23.706651997280673 145.539014669386 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0019730 4 antimicrobial humoral response 29 34 4 4 4 4 4 4 65 30 2448 0.99809 0.012398 0.012398 11.76 84386;360918;170568;287562 slpi;pf4;dmbt1;ccl12 SLPI_9890;PF4_32963;DMBT1_32993;CCL12_8217 52.4029 41.024100000000004 21.7434 38.8696459876684 41.212428561046515 27.943211803751673 29.949375000000003 26.644849999999998 12.6557 20.117599300343127 25.098083208171836 16.827061898468692 176.8325 135.18 100.108 109.91911773815025 205.1893669250646 123.46535701187574 0.5 23.63615 2.5 81.16964999999999 56.5193;105.82;21.7434;25.5289 39.3315;53.8521;12.6557;13.9582 100.108;109.875;160.485;336.862 1 3 1 170568 DMBT1_32993 21.7434 21.7434 12.6557 12.6557 160.485 160.485 21.7434 12.6557 160.485 3 84386;360918;287562 SLPI_9890;PF4_32963;CCL12_8217 62.622733333333336 56.5193 40.49202524748958 35.71393333333333 39.3315 20.19148101906677 182.28166666666667 109.875 133.9595392733692 56.5193;105.82;25.5289 39.3315;53.8521;13.9582 100.108;109.875;336.862 0 Exp 3,1(0.25);Linear,1(0.25);Poly 2,2(0.5) 1.634237208741268 6.553473353385925 1.5314651727676392 1.8398383855819702 0.13740812887268056 1.591084897518158 14.310646932084964 90.49515306791503 10.23412768566373 49.66462231433627 69.11176461661277 284.55323538338723 DOWN 0.25 0.75 0.0 GO:0001666 4 response to hypoxia 168 175 7 6 6 6 5 5 64 170 2308 0.66387 0.51954 0.80958 2.86 24825;362282;299923;290350;24770 tf;pck1;ndrg1;loxl2;ccl2 TF_10003;PCK1_9439;NDRG1_32364;LOXL2_9150;CCL2_8218 57.208754 64.0097 5.51457 33.99415273831045 71.7697235410233 27.98987699292421 33.080188 41.1311 1.34064 17.948206506938803 39.31001077873299 10.8395078698727 98.66966 105.409 39.6721 38.073453235397515 108.24246776145561 26.435201813002713 51.412;5.51457;99.6641;65.4434;64.0097 36.6131;1.34064;42.5546;43.7615;41.1311 86.0232;39.6721;105.409;129.393;132.851 2 3 2 24825;362282 TF_10003;PCK1_9439 28.463285 28.463285 32.45438399203488 18.97687 18.97687 24.941395655131252 62.84765 62.84765 32.77517712545579 51.412;5.51457 36.6131;1.34064 86.0232;39.6721 3 299923;290350;24770 NDRG1_32364;LOXL2_9150;CCL2_8218 76.37240000000001 65.4434 20.183937687923944 42.4824 42.5546 1.3166854863635877 122.551 129.393 14.94575404588212 99.6641;65.4434;64.0097 42.5546;43.7615;41.1311 105.409;129.393;132.851 0 Exp 2,1(0.2);Exp 3,1(0.2);Hill,1(0.2);Linear,2(0.4) 1.8095180955308388 9.16974663734436 1.5226441621780396 2.3449018001556396 0.34336741259940706 1.7373461723327637 27.411565346733862 87.00594265326613 17.347891349102078 48.81248465089792 65.29680680757681 132.04251319242317 DOWN 0.4 0.6 0.0 GO:0008284 6 positive regulation of cell population proliferation 272 293 10 10 9 6 6 6 63 287 2191 0.30304 0.82329 0.56821 2.05 24825;24516;114851;58919;24770;289054 tf;jun;cdkn1a;ccnd1;ccl2;aspm TF_10003;JUN_8938;CDKN1A_8271;CCND1_8224;CCL2_8218;ASPM_8092 44.38746666666666 52.9799 10.3235 20.673041859452308 46.11540887532285 17.714811441848212 30.7501 37.4559 7.4611 13.23418949478963 32.283667363230805 11.198605315066628 79.59821666666666 90.24665 16.8623 43.82742628115033 80.84518422164828 37.96102566128049 51.412;57.7663;54.5478;28.2655;64.0097;10.3235 36.6131;38.6865;38.2987;22.3101;41.1311;7.4611 86.0232;109.049;94.4701;38.3337;132.851;16.8623 3 3 3 24825;58919;289054 TF_10003;CCND1_8224;ASPM_8092 30.000333333333334 28.2655 20.599112677087163 22.1281 22.3101 14.576852163618868 47.07306666666667 38.3337 35.399010148637394 51.412;28.2655;10.3235 36.6131;22.3101;7.4611 86.0232;38.3337;16.8623 3 24516;114851;24770 JUN_8938;CDKN1A_8271;CCL2_8218 58.7746 57.7663 4.810861624491021 39.372099999999996 38.6865 1.535629499586546 112.12336666666666 109.049 19.37426563778198 57.7663;54.5478;64.0097 38.6865;38.2987;41.1311 109.049;94.4701;132.851 0 Exp 2,2(0.34);Linear,3(0.5);Poly 2,1(0.17) 1.7403247622890403 10.565294981002808 1.5230457782745361 2.2675669193267822 0.30625738280231996 1.6122539639472961 27.84558803096048 60.92934530237285 20.16054293563155 41.33965706436845 44.52897183143388 114.66746150189944 CONFLICT 0.5 0.5 0.0 GO:0045597 6 positive regulation of cell differentiation 285 303 11 11 11 9 9 9 60 294 2184 0.69888 0.43842 0.70731 2.97 29142;24825;360918;290350;24516;361921;170568;289054;29657 vnn1;tf;pf4;loxl2;jun;ect2;dmbt1;aspm;arntl VNN1_10157;TF_10003;PF4_32963;LOXL2_9150;JUN_8938;ECT2_8523;DMBT1_32993;ASPM_8092;ARNTL_8086 42.88987777777778 38.2177 10.3235 30.798087583516356 43.048190706650075 25.289578024936446 27.42948333333333 27.1236 7.4611 16.648965413277192 28.429831605007237 14.99771618272482 81.27928888888889 86.0232 16.8623 50.36561881307142 90.00482059010233 48.264491575079035 20.8684;51.412;105.82;65.4434;57.7663;14.4142;21.7434;10.3235;38.2177 17.1194;36.6131;53.8521;43.7615;38.6865;9.59235;12.6557;7.4611;27.1236 26.5474;86.0232;109.875;129.393;109.049;30.0753;160.485;16.8623;63.2034 5 4 5 29142;24825;361921;170568;289054 VNN1_10157;TF_10003;ECT2_8523;DMBT1_32993;ASPM_8092 23.7523 20.8684 16.16279944471253 16.68833 12.6557 11.71472461528653 63.99864 30.0753 60.352965610920904 20.8684;51.412;14.4142;21.7434;10.3235 17.1194;36.6131;9.59235;12.6557;7.4611 26.5474;86.0232;30.0753;160.485;16.8623 4 360918;290350;24516;29657 PF4_32963;LOXL2_9150;JUN_8938;ARNTL_8086 66.81184999999999 61.60485 28.419217739937896 40.855925 41.224000000000004 11.114946175420739 102.8801 109.462 28.072277799280915 105.82;65.4434;57.7663;38.2177 53.8521;43.7615;38.6865;27.1236 109.875;129.393;109.049;63.2034 0 Exp 2,2(0.23);Exp 3,1(0.12);Linear,2(0.23);Poly 2,3(0.34);Power,1(0.12) 2.018278141088678 19.569356679916382 1.5230457782745361 4.897102355957031 1.076427856125018 1.7797720432281494 22.76846055654709 63.01129499900846 16.55215926332557 38.306807403341104 48.373751264348904 114.18482651342887 CONFLICT 0.5555555555555556 0.4444444444444444 0.0 GO:0002252 3 immune effector process 125 137 3 3 3 3 3 3 66 134 2344 0.48573 0.72834 1.0 2.19 314654;286918;29339 myo1f;mx2;apcs MYO1F_32715;MX2_9268;APCS_8057 75.19069999999999 91.9576 31.6605 38.02815716373855 69.09279674071908 41.019655037126746 47.74323333333333 58.4986 23.5989 20.95102828797036 43.54878862418396 21.771964920920606 184.37133333333335 110.707 46.786 185.7183076875657 190.25560825294747 198.20661250768254 91.9576;31.6605;101.954 61.1322;23.5989;58.4986 110.707;46.786;395.621 1 2 1 314654 MYO1F_32715 91.9576 91.9576 61.1322 61.1322 110.707 110.707 91.9576 61.1322 110.707 2 286918;29339 MX2_9268;APCS_8057 66.80725 66.80725 49.70501052333657 41.04875 41.04875 24.67781453137617 221.2035 221.2035 246.66359401520936 31.6605;101.954 23.5989;58.4986 46.786;395.621 0 Exp 2,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 1.8987966156257825 5.867386817932129 1.5863633155822754 2.6565301418304443 0.6071533104452598 1.6244933605194092 32.15778912047109 118.2236108795289 24.03491296248942 71.45155370417726 -25.788715942908 394.5313826095746 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0043200 5 response to amino acid 78 82 7 7 7 7 7 7 62 75 2403 0.99862 0.0059527 0.0059527 8.54 25044;362282;24450;29680;84032;24770;25612 sds;pck1;hmgcs2;cyp11a1;col3a1;ccl2;asns SDS_9798;PCK1_9439;HMGCS2_8812;CYP11A1_32785;COL3A1_8354;CCL2_8218;ASNS_8091 50.30325285714286 57.8774 5.51457 26.273209131221304 54.38398858357063 25.289082777225268 33.86857714285714 39.4215 1.34064 16.895357513026788 36.768697496764176 14.846177388490894 104.98725714285716 106.603 39.6721 65.37146677860446 114.05997139097421 74.070716520819 3.5 60.94355 64.7394;5.51457;30.5985;43.719;57.8774;64.0097;85.6642 43.4259;1.34064;24.577;33.4848;39.4215;41.1311;53.6991 126.828;39.6721;40.5656;63.9031;106.603;132.851;224.488 4 3 4 362282;24450;29680;25612 PCK1_9439;HMGCS2_8812;CYP11A1_32785;ASNS_8091 41.374067499999995 37.15875 33.5118434845388 28.275385 29.030900000000003 21.699937241588973 92.1572 52.234350000000006 88.93089772030866 5.51457;30.5985;43.719;85.6642 1.34064;24.577;33.4848;53.6991 39.6721;40.5656;63.9031;224.488 3 25044;84032;24770 SDS_9798;COL3A1_8354;CCL2_8218 62.20883333333334 64.0097 3.7688329179377638 41.32616666666667 41.1311 2.009314085287121 122.094 126.828 13.749452461825639 64.7394;57.8774;64.0097 43.4259;39.4215;41.1311 126.828;106.603;132.851 0 Exp 2,5(0.72);Hill,1(0.15);Linear,1(0.15) 1.9444240840886913 14.129714727401733 1.559963583946228 3.3687045574188232 0.6561482860934558 1.752767562866211 30.839787155798035 69.76671855848768 21.352321141378376 46.38483314433591 56.55939684085886 153.4151174448554 CONFLICT 0.5714285714285714 0.42857142857142855 0.0 GO:0008150 1 biological_process 2293 2547 92 88 83 78 69 69 0 2478 0 1.0 1.0 1.0 2.71 29142;360847;360243;24825;78968;84386;29503;24777;291441;25044;83792;287877;29692;360918;362282;338475;316351;114519;24587;299923;314654;286918;58827;366960;290350;287167;100911740;304477;25087;293502;303575;24516;79438;24450;85430;362376;24440;360504;316033;81660;81714;24367;171142;361921;29740;116663;170568;24309;24306;25086;499353;29680;299691;84032;498709;306575;114851;297594;58919;24770;287562;791259;282840;289054;25612;29657;25649;29339;81639 vnn1;ube2t;top2a;tf;srebf1;slpi;slc22a2;slc10a1;ska1;sds;scd2;pycr1;pla2g2a;pf4;pck1;nrep;npas2;nfil3;nefh;ndrg1;myo1f;mx2;mest;maff;loxl2;hba-a1;mrln;kntc1;kng2l1;kif22;kif18b;jun;igfals;hmgcs2;herpud1;herc6;hbb;hba-a2;glb1;gatm;gas5;fgg;ehhadh;ect2;eci1;dusp6;dmbt1;dbp;cyp4a2;cyp2e1;cyp2c24;cyp11a1;cry1;col3a1;cks2;ckap2;cdkn1a;cdca3;ccnd1;ccl2;ccl12;car14;atf5;aspm;asns;arntl;apoa2;apcs;alox15 VNN1_10157;UBE2T_10125;TOP2A_10059;TF_10003;SREBF1_32750;SLPI_9890;SLC22A2_9845;SLC10A1_9832;SKA1_9829;SDS_9798;SCD_9786;PYCR1_9631;PLA2G2A_32641;PF4_32963;PCK1_9439;NREP_9364;NPAS2_9350;NFIL3_9304;NEFH_33218;NDRG1_32364;MYO1F_32715;MX2_9268;MEST_9219;MAFF_9172;LOXL2_9150;LOC287167_9118;LOC100911740_32571;KNTC1_8976;KNG2_8975;KIF22_8963;KIF18B_32882;JUN_8938;IGFALS_8880;HMGCS2_8812;HERPUD1_8795;HERC6_8794;HBB_8782;HBA2_32600;GLB1_8712;GATM_32792;GAS5_8688;FGG_8639;EHHADH_8534;ECT2_8523;ECI1_8520;DUSP6_8506;DMBT1_32993;DBP_8439;CYP4A2_8425;CYP2E1_8421;CYP2C24_32875;CYP11A1_32785;CRY1_8386;COL3A1_8354;CKS2_8325;CKAP2_8324;CDKN1A_8271;CDCA3_8260;CCND1_8224;CCL2_8218;CCL12_8217;CAR14_8195;ATF5_8097;ASPM_8092;ASNS_8091;ARNTL_8086;APOA2_33095;APCS_8057;ALOX15_8036 51.732867826086974 53.833 1.16694E-12 32.66507580007722 53.56085545841666 30.71723795357796 33.89871018840582 36.6131 1.16694E-12 21.15745806523269 34.85469595657961 19.56686740200464 107.02630101449277 94.9303 1.16694E-12 92.96080320084378 117.22264701537115 97.26953320710385 20.8684;10.9914;13.8391;51.412;11.2357;56.5193;81.8219;7.96762;11.9206;64.7394;83.9984;54.7122;1.16694E-12;105.82;5.51457;36.861;58.2312;33.1149;79.3182;99.6641;91.9576;31.6605;96.9172;58.0695;65.4434;105.203;91.003;7.89839;73.9369;13.2391;3.6768;57.7663;70.3663;30.5985;53.893;53.833;91.4283;101.406;65.9159;37.423;39.7267;93.1824;32.6956;14.4142;103.231;45.5478;21.7434;50.6952;59.5671;49.5529;10.5651;43.719;37.2548;57.8774;14.4197;12.1218;54.5478;2.6193;28.2655;64.0097;25.5289;98.1742;97.9563;10.3235;85.6642;38.2177;80.183;101.954;105.624 17.1194;7.86591;9.31624;36.6131;4.94421;39.3315;46.3605;6.07525;8.34831;43.4259;54.1928;38.3856;1.16694E-12;53.8521;1.34064;28.0333;35.795;25.603;39.4261;42.5546;61.1322;23.5989;56.7353;40.1293;43.7615;82.0435;54.5666;3.83458;52.6626;9.02099;1.12034;38.6865;46.0459;24.577;37.9512;36.3389;54.7263;84.6435;47.8573;28.03;30.1129;51.338;25.6436;9.59235;49.9975;33.3115;12.6557;40.5862;43.4174;26.9979;7.63639;33.4848;21.8798;39.4215;9.6236;8.47044;38.2987;0.978353;22.3101;41.1311;13.9582;55.9966;75.2121;7.4611;53.6991;27.1236;50.2978;58.4986;83.8302 26.5474;18.2059;27.6952;86.0232;24.5771;100.108;102.079;11.4863;21.0483;126.828;206.18;94.9303;1.16694E-12;109.875;39.6721;53.5645;99.4319;46.6318;264.141;105.409;110.707;46.786;331.492;104.733;129.393;130.247;273.335;12.5679;140.016;25.4349;11.7489;109.049;148.796;40.5656;92.6554;98.3689;277.036;115.953;114.587;55.6613;58.3946;327.378;45.0542;30.0753;107.244;71.7388;160.485;59.5346;99.5908;71.5977;17.0471;63.9031;73.8251;106.603;29.0958;21.3803;94.4701;7.96997;38.3337;132.851;336.862;356.234;114.804;16.8623;224.488;63.2034;197.161;395.621;129.44 37 32 37 29142;360847;360243;24825;78968;29503;291441;83792;287877;362282;314654;366960;287167;304477;25087;293502;303575;24450;85430;360504;316033;81714;171142;361921;29740;170568;24306;25086;29680;498709;306575;297594;58919;289054;25612;25649;81639 VNN1_10157;UBE2T_10125;TOP2A_10059;TF_10003;SREBF1_32750;SLC22A2_9845;SKA1_9829;SCD_9786;PYCR1_9631;PCK1_9439;MYO1F_32715;MAFF_9172;LOC287167_9118;KNTC1_8976;KNG2_8975;KIF22_8963;KIF18B_32882;HMGCS2_8812;HERPUD1_8795;HBA2_32600;GLB1_8712;GAS5_8688;EHHADH_8534;ECT2_8523;ECI1_8520;DMBT1_32993;CYP4A2_8425;CYP2E1_8421;CYP11A1_32785;CKS2_8325;CKAP2_8324;CDCA3_8260;CCND1_8224;ASPM_8092;ASNS_8091;APOA2_33095;ALOX15_8036 44.75621243243243 39.7267 33.94921139447264 30.757623324324328 26.9979 24.206478832012774 76.95270189189188 63.9031 58.70773317049109 20.8684;10.9914;13.8391;51.412;11.2357;81.8219;11.9206;83.9984;54.7122;5.51457;91.9576;58.0695;105.203;7.89839;73.9369;13.2391;3.6768;30.5985;53.893;101.406;65.9159;39.7267;32.6956;14.4142;103.231;21.7434;59.5671;49.5529;43.719;14.4197;12.1218;2.6193;28.2655;10.3235;85.6642;80.183;105.624 17.1194;7.86591;9.31624;36.6131;4.94421;46.3605;8.34831;54.1928;38.3856;1.34064;61.1322;40.1293;82.0435;3.83458;52.6626;9.02099;1.12034;24.577;37.9512;84.6435;47.8573;30.1129;25.6436;9.59235;49.9975;12.6557;43.4174;26.9979;33.4848;9.6236;8.47044;0.978353;22.3101;7.4611;53.6991;50.2978;83.8302 26.5474;18.2059;27.6952;86.0232;24.5771;102.079;21.0483;206.18;94.9303;39.6721;110.707;104.733;130.247;12.5679;140.016;25.4349;11.7489;40.5656;92.6554;115.953;114.587;58.3946;45.0542;30.0753;107.244;160.485;99.5908;71.5977;63.9031;29.0958;21.3803;7.96997;38.3337;16.8623;224.488;197.161;129.44 32 84386;24777;25044;29692;360918;338475;316351;114519;24587;299923;286918;58827;290350;100911740;24516;79438;362376;24440;81660;24367;116663;24309;499353;299691;84032;114851;24770;287562;791259;282840;29657;29339 SLPI_9890;SLC10A1_9832;SDS_9798;PLA2G2A_32641;PF4_32963;NREP_9364;NPAS2_9350;NFIL3_9304;NEFH_33218;NDRG1_32364;MX2_9268;MEST_9219;LOXL2_9150;LOC100911740_32571;JUN_8938;IGFALS_8880;HERC6_8794;HBB_8782;GATM_32792;FGG_8639;DUSP6_8506;DBP_8439;CYP2C24_32875;CRY1_8386;COL3A1_8354;CDKN1A_8271;CCL2_8218;CCL12_8217;CAR14_8195;ATF5_8097;ARNTL_8086;APCS_8057 59.799625625000026 57.82185 29.61117673711654 37.530591875000034 39.3765 16.61509232206632 141.79890000000006 106.006 112.36503743524716 56.5193;7.96762;64.7394;1.16694E-12;105.82;36.861;58.2312;33.1149;79.3182;99.6641;31.6605;96.9172;65.4434;91.003;57.7663;70.3663;53.833;91.4283;37.423;93.1824;45.5478;50.6952;10.5651;37.2548;57.8774;54.5478;64.0097;25.5289;98.1742;97.9563;38.2177;101.954 39.3315;6.07525;43.4259;1.16694E-12;53.8521;28.0333;35.795;25.603;39.4261;42.5546;23.5989;56.7353;43.7615;54.5666;38.6865;46.0459;36.3389;54.7263;28.03;51.338;33.3115;40.5862;7.63639;21.8798;39.4215;38.2987;41.1311;13.9582;55.9966;75.2121;27.1236;58.4986 100.108;11.4863;126.828;1.16694E-12;109.875;53.5645;99.4319;46.6318;264.141;105.409;46.786;331.492;129.393;273.335;109.049;148.796;98.3689;277.036;55.6613;327.378;71.7388;59.5346;17.0471;73.8251;106.603;94.4701;132.851;336.862;356.234;114.804;63.2034;395.621 0 Exp 2,20(0.29);Exp 3,3(0.05);Exp 4,2(0.03);Exp 5,1(0.02);Hill,3(0.05);Linear,18(0.27);Poly 2,20(0.29);Power,2(0.03) 1.9425810992661776 140.35382342338562 1.5059963464736938 5.737884044647217 0.7746436576834685 1.8151482343673706 44.02533831413188 59.44039733804204 28.90647525731933 38.89094511949229 85.09161644462388 128.96098558436165 CONFLICT 0.5362318840579711 0.463768115942029 0.0 GO:0046883 5 regulation of hormone secretion 83 89 4 4 4 4 4 4 65 85 2393 0.90913 0.21951 0.30257 4.49 78968;24367;299691;29657 srebf1;fgg;cry1;arntl SREBF1_32750;FGG_8639;CRY1_8386;ARNTL_8086 44.97265 37.73625 11.2357 34.4845682805609 41.171045292633714 23.017798983503432 26.321402499999998 24.5017 4.94421 19.176251486809367 25.28331054137235 12.771223646535194 122.2459 68.51425 24.5771 138.38227683093427 93.15990273461149 96.59404501480245 11.2357;93.1824;37.2548;38.2177 4.94421;51.338;21.8798;27.1236 24.5771;327.378;73.8251;63.2034 1 3 1 78968 SREBF1_32750 11.2357 11.2357 4.94421 4.94421 24.5771 24.5771 11.2357 4.94421 24.5771 3 24367;299691;29657 FGG_8639;CRY1_8386;ARNTL_8086 56.2183 38.2177 32.01546986551971 33.44713333333333 27.1236 15.714219426154559 154.80216666666666 73.8251 149.54938587551382 93.1824;37.2548;38.2177 51.338;21.8798;27.1236 327.378;73.8251;63.2034 0 Exp 2,2(0.5);Hill,1(0.25);Power,1(0.25) 2.655726359957471 11.525667309761047 1.8622472286224365 4.897102355957031 1.4198665555917611 2.38315886259079 11.177773085050319 78.76752691494968 7.528676042926822 45.11412895707318 -13.368731294315594 257.8605312943156 DOWN 0.25 0.75 0.0 GO:2000425 7 regulation of apoptotic cell clearance 5 6 2 2 2 2 2 2 67 4 2474 0.99964 0.010113 0.010113 33.33 24770;81639 ccl2;alox15 CCL2_8218;ALOX15_8036 84.81684999999999 84.81684999999999 64.0097 29.425753724331358 93.27704511317961 26.88354849231893 62.480650000000004 62.480650000000004 41.1311 30.192823160562508 71.16138515972077 27.584347818619428 131.1455 131.1455 129.44 2.411941230626261 130.4520430505606 2.2035642533287145 0.0 64.0097 0.0 64.0097 64.0097;105.624 41.1311;83.8302 132.851;129.44 1 1 1 81639 ALOX15_8036 105.624 105.624 83.8302 83.8302 129.44 129.44 105.624 83.8302 129.44 1 24770 CCL2_8218 64.0097 64.0097 41.1311 41.1311 132.851 132.851 64.0097 41.1311 132.851 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.6243786450925857 3.2514171600341797 1.559963583946228 1.6914535760879517 0.09297746510157863 1.6257085800170898 44.03483599999999 125.59886399999999 20.635532000000005 104.32576800000001 127.80272 134.48828 CONFLICT 0.5 0.5 0.0 GO:0006259 5 DNA metabolic process 110 119 3 3 3 3 3 3 66 116 2362 0.59552 0.63452 1.0 2.52 360847;360243;293502 ube2t;top2a;kif22 UBE2T_10125;TOP2A_10059;KIF22_8963 12.689866666666667 13.2391 10.9914 1.5011967770193662 12.194811097981292 1.5280899090706994 8.73438 9.02099 7.86591 0.7664680334495227 8.482038274741509 0.781582882655337 23.778666666666666 25.4349 18.2059 4.9567161774034805 22.134327759724275 5.009788124979171 10.9914;13.8391;13.2391 7.86591;9.31624;9.02099 18.2059;27.6952;25.4349 3 0 3 360847;360243;293502 UBE2T_10125;TOP2A_10059;KIF22_8963 12.689866666666667 13.2391 1.5011967770193662 8.73438 9.02099 0.7664680334495227 23.778666666666666 25.4349 4.9567161774034805 10.9914;13.8391;13.2391 7.86591;9.31624;9.02099 18.2059;27.6952;25.4349 0 0 Poly 2,3(1) 1.9344459053716856 5.874625563621521 1.616806149482727 2.363434076309204 0.37738357718856463 1.8943853378295898 10.991102594561957 14.388630738771377 7.867039770142827 9.601720229857172 18.169614284798545 29.387719048534787 UP 1.0 0.0 0.0 GO:0009410 4 response to xenobiotic stimulus 123 132 4 4 4 4 4 4 65 128 2350 0.71455 0.48451 0.78022 3.03 362282;24587;79438;24770 pck1;nefh;igfals;ccl2 PCK1_9439;NEFH_33218;IGFALS_8880;CCL2_8218 54.802192500000004 67.18799999999999 5.51457 33.453071568376075 68.28985489919464 21.543442366254332 31.985935 40.2786 1.34064 20.62204984591898 39.226877146100215 12.863091487574476 146.365025 140.8235 39.6721 92.09252420511213 186.1128415058646 82.07535499384223 5.51457;79.3182;70.3663;64.0097 1.34064;39.4261;46.0459;41.1311 39.6721;264.141;148.796;132.851 1 3 1 362282 PCK1_9439 5.51457 5.51457 1.34064 1.34064 39.6721 39.6721 5.51457 1.34064 39.6721 3 24587;79438;24770 NEFH_33218;IGFALS_8880;CCL2_8218 71.2314 70.3663 7.690828405965331 42.201033333333335 41.1311 3.4371508569356846 181.92933333333335 148.796 71.64237125007331 79.3182;70.3663;64.0097 39.4261;46.0459;41.1311 264.141;148.796;132.851 0 Exp 2,2(0.5);Hill,1(0.25);Linear,1(0.25) 1.7726631425930572 7.199548244476318 1.527578592300415 2.3449018001556396 0.37851946421815674 1.6635339260101318 22.018182362991446 87.58620263700854 11.776326150999413 52.1955438490006 56.114351278990085 236.61569872100992 DOWN 0.25 0.75 0.0 GO:0043547 7 positive regulation of GTPase activity 63 68 4 4 4 4 4 4 65 64 2414 0.96486 0.11027 0.11027 5.88 24516;361921;24770;287562 jun;ect2;ccl2;ccl12 JUN_8938;ECT2_8523;CCL2_8218;CCL12_8217 40.429775 41.6476 14.4142 24.189627118715567 36.62231743327918 21.61407480913702 25.842037500000004 26.32235 9.59235 16.37084386561339 22.89221319099559 15.145517350093233 152.209325 120.95 30.0753 130.70435959098367 199.70569561383152 146.29958625074508 2.5 60.888 57.7663;14.4142;64.0097;25.5289 38.6865;9.59235;41.1311;13.9582 109.049;30.0753;132.851;336.862 1 3 1 361921 ECT2_8523 14.4142 14.4142 9.59235 9.59235 30.0753 30.0753 14.4142 9.59235 30.0753 3 24516;24770;287562 JUN_8938;CCL2_8218;CCL12_8217 49.101633333333325 57.7663 20.651884381172934 31.2586 38.6865 15.032361671074838 192.92066666666668 132.851 125.22365743873375 57.7663;64.0097;25.5289 38.6865;41.1311;13.9582 109.049;132.851;336.862 0 Exp 2,2(0.5);Poly 2,2(0.5) 1.5952352243254617 6.394246578216553 1.5230457782745361 1.7797720432281494 0.12183541009143058 1.5457143783569336 16.72394042365874 64.13560957634127 9.798610511698875 41.88546448830113 24.119052600836 280.299597399164 DOWN 0.25 0.75 0.0 GO:0051270 5 regulation of cellular component movement 281 294 12 12 9 8 7 7 62 287 2191 0.4478 0.70049 0.84952 2.38 24825;24587;314654;24516;84032;24770;287562 tf;nefh;myo1f;jun;col3a1;ccl2;ccl12 TF_10003;NEFH_33218;MYO1F_32715;JUN_8938;COL3A1_8354;CCL2_8218;CCL12_8217 61.1243 57.8774 25.5289 21.107722580926023 56.98791101330485 24.690598368758 38.6241 39.4215 13.9582 13.703000297623406 34.365766587780314 15.479549709797153 163.7480285714286 110.707 86.0232 96.70734192744823 205.65723119859163 110.5361442712469 51.412;79.3182;91.9576;57.7663;57.8774;64.0097;25.5289 36.6131;39.4261;61.1322;38.6865;39.4215;41.1311;13.9582 86.0232;264.141;110.707;109.049;106.603;132.851;336.862 2 5 2 24825;314654 TF_10003;MYO1F_32715 71.6848 71.6848 28.670068707277284 48.87265 48.87265 17.337621878591072 98.3651 98.3651 17.454082365452518 51.412;91.9576 36.6131;61.1322 86.0232;110.707 5 24587;24516;84032;24770;287562 NEFH_33218;JUN_8938;COL3A1_8354;CCL2_8218;CCL12_8217 56.900099999999995 57.8774 19.614887375027173 34.524680000000004 39.4215 11.532003237165707 189.90120000000002 132.851 104.68932410804838 79.3182;57.7663;57.8774;64.0097;25.5289 39.4261;38.6865;39.4215;41.1311;13.9582 264.141;109.049;106.603;132.851;336.862 0 Exp 2,4(0.58);Linear,1(0.15);Poly 2,2(0.29) 1.644341679287096 11.562310338020325 1.5230457782745361 2.0048909187316895 0.1758912472874312 1.5863633155822754 45.487480286219665 76.76111971378033 28.47277531917244 48.775424680827555 92.10622709707562 235.38983004578157 DOWN 0.2857142857142857 0.7142857142857143 0.0 GO:1901570 5 fatty acid derivative biosynthetic process 18 23 4 4 4 3 3 3 66 20 2458 0.99704 0.022863 0.022863 13.04 24450;24306;81639 hmgcs2;cyp4a2;alox15 HMGCS2_8812;CYP4A2_8425;ALOX15_8036 65.2632 59.5671 30.5985 37.8357050809153 65.95875889454916 37.63781931731539 50.608200000000004 43.4174 24.577 30.274017424848 51.11687076923077 30.16809942946995 89.86546666666668 99.5908 40.5656 45.22832436840141 90.93823162506368 44.739398453172214 0.5 45.082800000000006 1.5 82.59555 30.5985;59.5671;105.624 24.577;43.4174;83.8302 40.5656;99.5908;129.44 3 0 3 24450;24306;81639 HMGCS2_8812;CYP4A2_8425;ALOX15_8036 65.2632 59.5671 37.8357050809153 50.608200000000004 43.4174 30.274017424848 89.86546666666668 99.5908 45.22832436840141 30.5985;59.5671;105.624 24.577;43.4174;83.8302 40.5656;99.5908;129.44 0 0 Exp 2,2(0.67);Poly 2,1(0.34) 2.218041582458873 6.975234270095825 1.6914535760879517 3.3687045574188232 0.91069693914281 1.9150761365890503 22.44806915364635 108.07833084635365 16.349924265012667 84.86647573498732 38.68479957844584 141.0461337548875 UP 1.0 0.0 0.0 GO:0070741 6 response to interleukin-6 14 14 3 3 3 3 3 3 66 11 2467 0.9996 0.0055922 0.0055922 21.43 362282;24367;24770 pck1;fgg;ccl2 PCK1_9439;FGG_8639;CCL2_8218 54.23555666666667 64.0097 5.51457 44.64372870463032 61.37523520571608 39.21290417467023 31.269913333333335 41.1311 1.34064 26.41715831800486 36.030726253140706 22.981965403356888 166.6337 132.851 39.6721 146.7979030441852 179.4792469692211 137.9846654134022 0.0 5.51457 0.5 34.762135 5.51457;93.1824;64.0097 1.34064;51.338;41.1311 39.6721;327.378;132.851 1 2 1 362282 PCK1_9439 5.51457 5.51457 1.34064 1.34064 39.6721 39.6721 5.51457 1.34064 39.6721 2 24367;24770 FGG_8639;CCL2_8218 78.59604999999999 78.59604999999999 20.628213995520863 46.23455 46.23455 7.217368204892991 230.1145 230.1145 137.5513608238755 93.1824;64.0097 51.338;41.1311 327.378;132.851 0 Exp 2,2(0.67);Hill,1(0.34) 1.9113518101018787 5.813763618469238 1.559963583946228 2.3449018001556396 0.39327312453955443 1.9088982343673706 3.716421847582666 104.75469148575066 1.376084539728204 61.163742126938466 0.5162346754954967 332.75116532450454 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0044271 5 cellular nitrogen compound biosynthetic process 201 229 5 4 4 5 4 4 65 225 2253 0.24207 0.88133 0.51922 1.75 78968;114519;24516;25612 srebf1;nfil3;jun;asns SREBF1_32750;NFIL3_9304;JUN_8938;ASNS_8091 46.945274999999995 45.4406 11.2357 32.05569504538156 55.29057108357964 29.289400462813916 30.7332025 32.14475 4.94421 20.672675209561657 36.31498466322873 18.069254106524138 101.186475 77.8404 24.5771 89.64800475368 121.04203547575624 88.02724283909602 11.2357;33.1149;57.7663;85.6642 4.94421;25.603;38.6865;53.6991 24.5771;46.6318;109.049;224.488 2 2 2 78968;25612 SREBF1_32750;ASNS_8091 48.449949999999994 48.449949999999994 52.62889706354296 29.321655 29.321655 34.474913335004196 124.53255 124.53255 141.35835302310576 11.2357;85.6642 4.94421;53.6991 24.5771;224.488 2 114519;24516 NFIL3_9304;JUN_8938 45.4406 45.4406 17.431172105742025 32.14475 32.14475 9.251431571654184 77.8404 77.8404 44.13562538267699 33.1149;57.7663 25.603;38.6865 46.6318;109.049 0 Exp 2,2(0.5);Hill,1(0.25);Linear,1(0.25) 2.1066150430239095 8.811951994895935 1.5230457782745361 2.857419490814209 0.7436915930980393 2.215743362903595 15.530693855526064 78.35985614447392 10.473980794629583 50.99242420537042 13.331430341393585 189.04151965860643 CONFLICT 0.5 0.5 0.0 GO:0045940 7 positive regulation of steroid metabolic process 23 25 2 2 2 2 2 2 67 23 2455 0.97143 0.14577 0.14577 8.0 78968;25649 srebf1;apoa2 SREBF1_32750;APOA2_33095 45.70935 45.70935 11.2357 48.75310337450326 67.47913159320136 37.80235849009452 27.621005 27.621005 4.94421 32.06983104015439 41.941185032685844 24.866422151306384 110.86905 110.86905 24.5771 122.03524601362099 165.3615944434068 94.62413259719568 0.5 45.70935 11.2357;80.183 4.94421;50.2978 24.5771;197.161 2 0 2 78968;25649 SREBF1_32750;APOA2_33095 45.70935 45.70935 48.75310337450326 27.621005 27.621005 32.06983104015439 110.86905 110.86905 122.03524601362099 11.2357;80.183 4.94421;50.2978 24.5771;197.161 0 0 Hill,1(0.5);Linear,1(0.5) 2.373340734498827 4.828689813613892 1.9712703227996826 2.857419490814209 0.6266020858458888 2.414344906806946 -21.85900399999999 113.277704 -16.82551319999999 72.0675232 -58.26317199999998 280.001272 UP 1.0 0.0 0.0 GO:0022607 5 cellular component assembly 355 395 11 11 10 9 8 8 61 387 2091 0.23424 0.86176 0.49871 2.03 25044;360918;24587;24367;361921;289054;25649;29339 sds;pf4;nefh;fgg;ect2;aspm;apoa2;apcs SDS_9798;PF4_32963;NEFH_33218;FGG_8639;ECT2_8523;ASPM_8092;APOA2_33095;APCS_8057 68.7418375 79.7506 10.3235 37.221638233000874 73.39568521992649 31.51144174127797 39.23649375 46.861850000000004 7.4611 19.854764144414116 42.378140301685896 17.40536501322285 183.4927 161.99450000000002 16.8623 137.4904717431409 215.446170498162 131.4132367387438 64.7394;105.82;79.3182;93.1824;14.4142;10.3235;80.183;101.954 43.4259;53.8521;39.4261;51.338;9.59235;7.4611;50.2978;58.4986 126.828;109.875;264.141;327.378;30.0753;16.8623;197.161;395.621 3 5 3 361921;289054;25649 ECT2_8523;ASPM_8092;APOA2_33095 34.97356666666667 14.4142 39.20590648567297 22.450416666666666 9.59235 24.140073022379894 81.3662 30.0753 100.49862000311248 14.4142;10.3235;80.183 9.59235;7.4611;50.2978 30.0753;16.8623;197.161 5 25044;360918;24587;24367;29339 SDS_9798;PF4_32963;NEFH_33218;FGG_8639;APCS_8057 89.00280000000001 93.1824 16.95969420537999 49.30814 51.338 7.769940815282941 244.76859999999996 264.141 124.56154892782928 64.7394;105.82;79.3182;93.1824;101.954 43.4259;53.8521;39.4261;51.338;58.4986 126.828;109.875;264.141;327.378;395.621 0 Exp 2,2(0.25);Exp 3,1(0.13);Linear,3(0.38);Poly 2,2(0.25) 1.7888029687010043 14.354616641998291 1.5452834367752075 1.9712703227996826 0.14813611236839827 1.8098052144050598 42.94855815460116 94.53511684539882 25.477844151932754 52.995143348067245 88.21666398024995 278.76873601975007 DOWN 0.375 0.625 0.0 GO:0002244 5 hematopoietic progenitor cell differentiation 30 31 2 2 2 2 2 2 67 29 2449 0.95021 0.20433 0.20433 6.45 360243;362376 top2a;herc6 TOP2A_10059;HERC6_8794 33.83605 33.83605 13.8391 28.279957896096665 45.877056264643535 22.57840461313929 22.82757 22.82757 9.31624 19.107906131698474 30.963311159210086 15.255540249970503 63.03205 63.03205 27.6952 49.973852521543684 84.30985647662612 39.89856938452175 0.5 33.83605 13.8391;53.833 9.31624;36.3389 27.6952;98.3689 1 1 1 360243 TOP2A_10059 13.8391 13.8391 9.31624 9.31624 27.6952 27.6952 13.8391 9.31624 27.6952 1 362376 HERC6_8794 53.833 53.833 36.3389 36.3389 98.3689 98.3689 53.833 36.3389 98.3689 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.6907264061974037 3.4033474922180176 1.5089621543884277 1.8943853378295898 0.27253534663775236 1.7016737461090088 -5.357971999999997 73.03007199999999 -3.654636799999995 49.309776799999995 -6.228175999999991 132.292276 CONFLICT 0.5 0.5 0.0 GO:1902749 8 regulation of cell cycle G2/M phase transition 30 32 3 3 3 3 3 3 66 29 2449 0.98999 0.053907 0.053907 9.38 114851;58919;282840 cdkn1a;ccnd1;atf5 CDKN1A_8271;CCND1_8224;ATF5_8097 60.25653333333333 54.5478 28.2655 35.194376374121674 62.522807563248996 34.25606378668013 45.27363333333333 38.2987 22.3101 27.131949289598303 46.81597976919662 26.626034163774406 82.53593333333333 94.4701 38.3337 39.60738499375255 86.24881003550821 37.47923251260457 0.5 41.40665 54.5478;28.2655;97.9563 38.2987;22.3101;75.2121 94.4701;38.3337;114.804 1 2 1 58919 CCND1_8224 28.2655 28.2655 22.3101 22.3101 38.3337 38.3337 28.2655 22.3101 38.3337 2 114851;282840 CDKN1A_8271;ATF5_8097 76.25205 76.25205 30.694444711136256 56.7554 56.7554 26.101715456651508 104.63705 104.63705 14.378238577969157 54.5478;97.9563 38.2987;75.2121 94.4701;114.804 0 Linear,2(0.67);Poly 2,1(0.34) 2.0805352133353217 6.31810736656189 1.6645443439483643 2.385996103286743 0.3869010078133433 2.2675669193267822 20.430347293155442 100.08271937351122 14.570942410395187 75.97632425627148 37.71595793277459 127.35590873389208 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0010646 5 regulation of cell communication 678 722 24 24 20 20 18 18 51 704 1774 0.39381 0.70689 0.78671 2.49 29142;24825;78968;29692;360918;338475;24516;85430;24367;116663;299691;84032;24770;287562;289054;29657;25649;81639 vnn1;tf;srebf1;pla2g2a;pf4;nrep;jun;herpud1;fgg;dusp6;cry1;col3a1;ccl2;ccl12;aspm;arntl;apoa2;alox15 VNN1_10157;TF_10003;SREBF1_32750;PLA2G2A_32641;PF4_32963;NREP_9364;JUN_8938;HERPUD1_8795;FGG_8639;DUSP6_8506;CRY1_8386;COL3A1_8354;CCL2_8218;CCL12_8217;ASPM_8092;ARNTL_8086;APOA2_33095;ALOX15_8036 49.75586666666673 48.4799 1.16694E-12 31.472163640327025 50.68067919809548 28.81999426350186 32.6084783333334 34.9623 1.16694E-12 20.51486443826349 33.94707776397142 20.781581722324255 108.78978888888895 89.33930000000001 1.16694E-12 94.32795483447086 127.0931168506845 100.27760603330182 20.8684;51.412;11.2357;1.16694E-12;105.82;36.861;57.7663;53.893;93.1824;45.5478;37.2548;57.8774;64.0097;25.5289;10.3235;38.2177;80.183;105.624 17.1194;36.6131;4.94421;1.16694E-12;53.8521;28.0333;38.6865;37.9512;51.338;33.3115;21.8798;39.4215;41.1311;13.9582;7.4611;27.1236;50.2978;83.8302 26.5474;86.0232;24.5771;1.16694E-12;109.875;53.5645;109.049;92.6554;327.378;71.7388;73.8251;106.603;132.851;336.862;16.8623;63.2034;197.161;129.44 7 11 7 29142;24825;78968;85430;289054;25649;81639 VNN1_10157;TF_10003;SREBF1_32750;HERPUD1_8795;ASPM_8092;APOA2_33095;ALOX15_8036 47.64851428571428 51.412 36.306637106385416 34.03100142857143 36.6131 27.70260957745102 81.8952 86.0232 66.15330248695072 20.8684;51.412;11.2357;53.893;10.3235;80.183;105.624 17.1194;36.6131;4.94421;37.9512;7.4611;50.2978;83.8302 26.5474;86.0232;24.5771;92.6554;16.8623;197.161;129.44 11 29692;360918;338475;24516;24367;116663;299691;84032;24770;287562;29657 PLA2G2A_32641;PF4_32963;NREP_9364;JUN_8938;FGG_8639;DUSP6_8506;CRY1_8386;COL3A1_8354;CCL2_8218;CCL12_8217;ARNTL_8086 51.0969090909092 45.5478 29.79689608430545 31.70323636363647 33.3115 15.895998579156267 125.90452727272738 106.603 108.03662626433756 1.16694E-12;105.82;36.861;57.7663;93.1824;45.5478;37.2548;57.8774;64.0097;25.5289;38.2177 1.16694E-12;53.8521;28.0333;38.6865;51.338;33.3115;21.8798;39.4215;41.1311;13.9582;27.1236 1.16694E-12;109.875;53.5645;109.049;327.378;71.7388;73.8251;106.603;132.851;336.862;63.2034 0 Exp 2,6(0.34);Exp 3,1(0.06);Hill,2(0.12);Linear,5(0.28);Poly 2,3(0.17);Power,1(0.06) 1.9089200710422203 36.15506839752197 1.5230457782745361 4.897102355957031 0.8131088890136398 1.765645980834961 35.21646885192395 64.29526448140952 23.131094490513068 42.085862176153725 65.21249702986597 152.36708074791193 DOWN 0.3888888888888889 0.6111111111111112 0.0 GO:0033044 7 regulation of chromosome organization 75 76 2 2 2 2 2 2 67 74 2404 0.66042 0.61768 1.0 2.63 360243;78968 top2a;srebf1 TOP2A_10059;SREBF1_32750 12.5374 12.5374 11.2357 1.840881794141057 12.471552555910543 1.838524954471331 7.130225 7.130225 4.94421 3.0914920605510208 7.019643836528222 3.0875340926086046 26.13615 26.13615 24.5771 2.2048296544177473 26.057284318423857 2.202006860465883 13.8391;11.2357 9.31624;4.94421 27.6952;24.5771 2 0 2 360243;78968 TOP2A_10059;SREBF1_32750 12.5374 12.5374 1.840881794141057 7.130225 7.130225 3.0914920605510208 26.13615 26.13615 2.2048296544177473 13.8391;11.2357 9.31624;4.94421 27.6952;24.5771 0 0 Hill,1(0.5);Poly 2,1(0.5) 2.326596997210073 4.751804828643799 1.8943853378295898 2.857419490814209 0.6809679800896672 2.3759024143218994 9.986068 15.088732 2.8456355999999996 11.414814400000001 23.080412000000003 29.191888 UP 1.0 0.0 0.0 GO:1901654 5 response to ketone 140 154 9 9 9 9 9 9 60 145 2333 0.99251 0.021228 0.033957 5.84 78968;362282;79438;24450;316033;29680;114851;58919;24770 srebf1;pck1;igfals;hmgcs2;glb1;cyp11a1;cdkn1a;ccnd1;ccl2 SREBF1_32750;PCK1_9439;IGFALS_8880;HMGCS2_8812;GLB1_8712;CYP11A1_32785;CDKN1A_8271;CCND1_8224;CCL2_8218 41.574774444444444 43.719 5.51457 24.02102851343751 45.751599107756206 20.710729052680303 28.88775 33.4848 1.34064 16.98465788815453 32.1362298082914 13.451396758396438 77.5284111111111 63.9031 24.5771 46.267001505890924 82.64322558511063 46.5419043675108 6.5 64.96279999999999 11.2357;5.51457;70.3663;30.5985;65.9159;43.719;54.5478;28.2655;64.0097 4.94421;1.34064;46.0459;24.577;47.8573;33.4848;38.2987;22.3101;41.1311 24.5771;39.6721;148.796;40.5656;114.587;63.9031;94.4701;38.3337;132.851 6 3 6 78968;362282;24450;316033;29680;58919 SREBF1_32750;PCK1_9439;HMGCS2_8812;GLB1_8712;CYP11A1_32785;CCND1_8224 30.874861666666664 29.432000000000002 22.03893130562407 22.419008333333334 23.443550000000002 17.457911705431922 53.606433333333335 40.11885 32.44946351529817 11.2357;5.51457;30.5985;65.9159;43.719;28.2655 4.94421;1.34064;24.577;47.8573;33.4848;22.3101 24.5771;39.6721;40.5656;114.587;63.9031;38.3337 3 79438;114851;24770 IGFALS_8880;CDKN1A_8271;CCL2_8218 62.9746 64.0097 7.9598875350095195 41.82523333333334 41.1311 3.9199671903388675 125.37236666666666 132.851 27.92442157150864 70.3663;54.5478;64.0097 46.0459;38.2987;41.1311 148.796;94.4701;132.851 0 Exp 2,4(0.45);Hill,2(0.23);Linear,3(0.34) 2.090795338730227 19.489024758338928 1.527578592300415 3.3687045574188232 0.6289252760578251 2.145577907562256 25.881035815665278 57.26851307322361 17.791106846405704 39.98439315359429 47.30063679392906 107.75618542829316 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0071357 7 cellular response to type I interferon 1 1 1 1 1 1 1 1 68 0 2478 1.0 0.027091 0.027091 100.0 286918 mx2 MX2_9268 31.6605 31.6605 31.6605 31.6605 23.5989 23.5989 23.5989 23.598900000000004 46.786 46.786 46.786 46.786 0.0 31.6605 0.0 31.6605 31.6605 23.5989 46.786 0 1 0 1 286918 MX2_9268 31.6605 31.6605 23.5989 23.5989 46.786 46.786 31.6605 23.5989 46.786 0 Exp 2,1(1) 2.6565301418304443 2.6565301418304443 2.6565301418304443 2.6565301418304443 0.0 2.6565301418304443 31.6605 31.6605 23.5989 23.5989 46.786 46.786 DOWN 0.0 1.0 0.0 GO:0016567 9 protein ubiquitination 75 76 4 4 4 4 4 4 65 72 2406 0.9472 0.14847 0.14847 5.26 360847;85430;362376;297594 ube2t;herpud1;herc6;cdca3 UBE2T_10125;HERPUD1_8795;HERC6_8794;CDCA3_8260 30.334175000000002 32.4122 2.6193 27.382903746239787 34.23347732944417 26.32001704003707 20.783590750000002 22.102405 0.978353 19.112023890008498 23.40505391735537 18.109847753622052 54.3000425 55.43065 7.96997 47.82767814760847 61.431687315940145 46.9863092410728 2.5 53.863 10.9914;53.893;53.833;2.6193 7.86591;37.9512;36.3389;0.978353 18.2059;92.6554;98.3689;7.96997 3 1 3 360847;85430;297594 UBE2T_10125;HERPUD1_8795;CDCA3_8260 22.501233333333335 10.9914 27.506458795041816 15.598487666666665 7.86591 19.661953663093257 39.61042333333334 18.2059 46.22251321506256 10.9914;53.893;2.6193 7.86591;37.9512;0.978353 18.2059;92.6554;7.96997 1 362376 HERC6_8794 53.833 53.833 36.3389 36.3389 98.3689 98.3689 53.833 36.3389 98.3689 0 Exp 2,1(0.25);Exp 4,1(0.25);Linear,1(0.25);Poly 2,1(0.25) 1.8870603391405036 7.727883219718933 1.5089621543884277 2.363434076309204 0.47825546335347546 1.9277434945106506 3.498929328685005 57.169420671314995 2.0538073377916746 39.51337416220833 7.428917915343703 101.17116708465629 UP 0.75 0.25 0.0 GO:0006139 4 nucleobase-containing compound metabolic process 359 401 9 9 9 8 8 8 61 393 2085 0.21823 0.87299 0.40429 2.0 360847;360243;78968;362282;114519;293502;24516;24450 ube2t;top2a;srebf1;pck1;nfil3;kif22;jun;hmgcs2 UBE2T_10125;TOP2A_10059;SREBF1_32750;PCK1_9439;NFIL3_9304;KIF22_8963;JUN_8938;HMGCS2_8812 22.037446250000002 13.539100000000001 5.51457 17.439178759054432 26.94023886217725 18.586361224371256 15.16931125 9.168614999999999 1.34064 12.937263159651259 19.176295282274946 13.20886104600619 41.47895 33.68365 18.2059 28.96074468621276 46.47114397069086 33.67414840334955 10.9914;13.8391;11.2357;5.51457;33.1149;13.2391;57.7663;30.5985 7.86591;9.31624;4.94421;1.34064;25.603;9.02099;38.6865;24.577 18.2059;27.6952;24.5771;39.6721;46.6318;25.4349;109.049;40.5656 6 2 6 360847;360243;78968;362282;293502;24450 UBE2T_10125;TOP2A_10059;SREBF1_32750;PCK1_9439;KIF22_8963;HMGCS2_8812 14.236395000000002 12.237400000000001 8.537860563733162 9.510831666666668 8.44345 7.969680942540714 29.35846666666667 26.56505 8.914851787139625 10.9914;13.8391;11.2357;5.51457;13.2391;30.5985 7.86591;9.31624;4.94421;1.34064;9.02099;24.577 18.2059;27.6952;24.5771;39.6721;25.4349;40.5656 2 114519;24516 NFIL3_9304;JUN_8938 45.4406 45.4406 17.431172105742025 32.14475 32.14475 9.251431571654184 77.8404 77.8404 44.13562538267699 33.1149;57.7663 25.603;38.6865 46.6318;109.049 0 Exp 2,2(0.25);Hill,2(0.25);Linear,1(0.13);Poly 2,3(0.38) 2.2702442081468144 18.804240584373474 1.5230457782745361 3.3687045574188232 0.6502967837167313 2.354167938232422 9.952711922325243 34.122180577674754 6.204245270019383 24.134377229980622 21.410177823283362 61.54772217671665 UP 0.75 0.25 0.0 GO:0007015 6 actin filament organization 44 45 2 2 2 2 2 2 67 43 2435 0.8793 0.34595 0.34595 4.44 24825;314654 tf;myo1f TF_10003;MYO1F_32715 71.6848 71.6848 51.412 28.670068707277284 70.2546201058201 28.5986365168091 48.87265 48.87265 36.6131 17.337621878591072 48.007778747795406 17.294424761732362 98.3651 98.3651 86.0232 17.454082365452518 97.49441922398589 17.41059508438925 51.412;91.9576 36.6131;61.1322 86.0232;110.707 2 0 2 24825;314654 TF_10003;MYO1F_32715 71.6848 71.6848 28.670068707277284 48.87265 48.87265 17.337621878591072 98.3651 98.3651 17.454082365452518 51.412;91.9576 36.6131;61.1322 86.0232;110.707 0 0 Linear,1(0.5);Poly 2,1(0.5) 1.7833915456847935 3.591254234313965 1.5863633155822754 2.0048909187316895 0.29594370630070294 1.7956271171569824 31.950112000000004 111.41948799999999 24.843932000000006 72.90136799999999 74.174976 122.555224 UP 1.0 0.0 0.0 GO:0007346 6 regulation of mitotic cell cycle 146 155 8 8 7 7 7 7 62 148 2330 0.94467 0.12297 0.19222 4.52 360243;304477;498709;114851;58919;24770;25612 top2a;kntc1;cks2;cdkn1a;ccnd1;ccl2;asns TOP2A_10059;KNTC1_8976;CKS2_8325;CDKN1A_8271;CCND1_8224;CCL2_8218;ASNS_8091 38.37777 28.2655 7.89839 29.89386286263955 39.43920055969398 29.435364133459554 25.459059999999997 22.3101 3.83458 19.13485287639983 26.438151098392247 19.176160869825853 79.9288142857143 38.3337 12.5679 76.90855718963545 79.40375168397136 76.13107757935369 13.8391;7.89839;14.4197;54.5478;28.2655;64.0097;85.6642 9.31624;3.83458;9.6236;38.2987;22.3101;41.1311;53.6991 27.6952;12.5679;29.0958;94.4701;38.3337;132.851;224.488 5 2 5 360243;304477;498709;58919;25612 TOP2A_10059;KNTC1_8976;CKS2_8325;CCND1_8224;ASNS_8091 30.017377999999997 14.4197 31.99184170772168 19.756724 9.6236 20.148220735545856 66.43612 29.0958 88.83564358902905 13.8391;7.89839;14.4197;28.2655;85.6642 9.31624;3.83458;9.6236;22.3101;53.6991 27.6952;12.5679;29.0958;38.3337;224.488 2 114851;24770 CDKN1A_8271;CCL2_8218 59.27875 59.27875 6.690573652908962 39.7149 39.7149 2.0028092470327894 113.66055 113.66055 27.139394658042768 54.5478;64.0097 38.2987;41.1311 94.4701;132.851 0 Exp 2,2(0.29);Exp 5,1(0.15);Linear,2(0.29);Poly 2,2(0.29) 1.7288632707014464 12.207379579544067 1.530501127243042 2.2675669193267822 0.26040861969633483 1.6645443439483643 16.232086478748176 60.523453521251824 11.28376261626639 39.634357383733615 22.95415780107635 136.90347077035221 UP 0.7142857142857143 0.2857142857142857 0.0 GO:0051050 5 positive regulation of transport 286 308 6 6 6 5 5 5 64 303 2175 0.14126 0.93384 0.26238 1.62 24825;24367;361921;24770;25649 tf;fgg;ect2;ccl2;apoa2 TF_10003;FGG_8639;ECT2_8523;CCL2_8218;APOA2_33095 60.64025999999999 64.0097 14.4142 30.307887150674187 62.35705373017698 28.420734742803926 37.794470000000004 41.1311 9.59235 16.938482615615253 39.47492674787406 16.51824900648233 154.6977 132.851 30.0753 114.39605072715581 151.21553246609975 96.10724421021054 51.412;93.1824;14.4142;64.0097;80.183 36.6131;51.338;9.59235;41.1311;50.2978 86.0232;327.378;30.0753;132.851;197.161 3 2 3 24825;361921;25649 TF_10003;ECT2_8523;APOA2_33095 48.66973333333334 51.412 32.97004372477132 32.167750000000005 36.6131 20.71362516298149 104.41983333333333 86.0232 85.0484266440205 51.412;14.4142;80.183 36.6131;9.59235;50.2978 86.0232;30.0753;197.161 2 24367;24770 FGG_8639;CCL2_8218 78.59604999999999 78.59604999999999 20.628213995520863 46.23455 46.23455 7.217368204892991 230.1145 230.1145 137.5513608238755 93.1824;64.0097 51.338;41.1311 327.378;132.851 0 Exp 2,2(0.4);Linear,2(0.4);Poly 2,1(0.2) 1.8374676844715803 9.22479510307312 1.559963583946228 2.0048909187316895 0.18103364403676908 1.9088982343673706 34.07422559806647 87.20629440193355 22.94723536282806 52.64170463717195 54.42514045289364 254.97025954710637 UP 0.6 0.4 0.0 GO:0051179 2 localization 693 737 27 26 24 26 23 23 46 714 1764 0.82977 0.24467 0.42071 3.12 24825;78968;29503;24777;29692;314654;286918;290350;287167;293502;85430;24440;360504;24367;170568;299691;114851;58919;287562;289054;29657;25649;81639 tf;srebf1;slc22a2;slc10a1;pla2g2a;myo1f;mx2;loxl2;hba-a1;kif22;herpud1;hbb;hba-a2;fgg;dmbt1;cry1;cdkn1a;ccnd1;ccl12;aspm;arntl;apoa2;alox15 TF_10003;SREBF1_32750;SLC22A2_9845;SLC10A1_9832;PLA2G2A_32641;MYO1F_32715;MX2_9268;LOXL2_9150;LOC287167_9118;KIF22_8963;HERPUD1_8795;HBB_8782;HBA2_32600;FGG_8639;DMBT1_32993;CRY1_8386;CDKN1A_8271;CCND1_8224;CCL12_8217;ASPM_8092;ARNTL_8086;APOA2_33095;ALOX15_8036 52.24083130434788 51.412 1.16694E-12 35.29883267162072 48.87907723969299 30.46857027322143 35.6532326086957 36.6131 1.16694E-12 25.86560051728248 33.283744406925436 22.324567910329698 112.62602173913051 94.4701 1.16694E-12 94.51931009516684 119.44952948399869 95.7006790395594 51.412;11.2357;81.8219;7.96762;1.16694E-12;91.9576;31.6605;65.4434;105.203;13.2391;53.893;91.4283;101.406;93.1824;21.7434;37.2548;54.5478;28.2655;25.5289;10.3235;38.2177;80.183;105.624 36.6131;4.94421;46.3605;6.07525;1.16694E-12;61.1322;23.5989;43.7615;82.0435;9.02099;37.9512;54.7263;84.6435;51.338;12.6557;21.8798;38.2987;22.3101;13.9582;7.4611;27.1236;50.2978;83.8302 86.0232;24.5771;102.079;11.4863;1.16694E-12;110.707;46.786;129.393;130.247;25.4349;92.6554;277.036;115.953;327.378;160.485;73.8251;94.4701;38.3337;336.862;16.8623;63.2034;197.161;129.44 13 10 13 24825;78968;29503;314654;287167;293502;85430;360504;170568;58919;289054;25649;81639 TF_10003;SREBF1_32750;SLC22A2_9845;MYO1F_32715;LOC287167_9118;KIF22_8963;HERPUD1_8795;HBA2_32600;DMBT1_32993;CCND1_8224;ASPM_8092;APOA2_33095;ALOX15_8036 58.17751538461539 53.893 37.98570353597622 41.48185384615385 37.9512 29.67884743614621 94.6122 102.079 55.59440378452373 51.412;11.2357;81.8219;91.9576;105.203;13.2391;53.893;101.406;21.7434;28.2655;10.3235;80.183;105.624 36.6131;4.94421;46.3605;61.1322;82.0435;9.02099;37.9512;84.6435;12.6557;22.3101;7.4611;50.2978;83.8302 86.0232;24.5771;102.079;110.707;130.247;25.4349;92.6554;115.953;160.485;38.3337;16.8623;197.161;129.44 10 24777;29692;286918;290350;24440;24367;299691;114851;287562;29657 SLC10A1_9832;PLA2G2A_32641;MX2_9268;LOXL2_9150;HBB_8782;FGG_8639;CRY1_8386;CDKN1A_8271;CCL12_8217;ARNTL_8086 44.52314200000011 37.73625 31.698932235404083 28.07602500000012 25.36125 18.65728656476005 136.04399000000012 84.14760000000001 128.99373945233359 7.96762;1.16694E-12;31.6605;65.4434;91.4283;93.1824;37.2548;54.5478;25.5289;38.2177 6.07525;1.16694E-12;23.5989;43.7615;54.7263;51.338;21.8798;38.2987;13.9582;27.1236 11.4863;1.16694E-12;46.786;129.393;277.036;327.378;73.8251;94.4701;336.862;63.2034 0 Exp 2,3(0.14);Hill,2(0.09);Linear,7(0.31);Poly 2,10(0.44);Power,1(0.05) 1.9292362860420817 46.24828255176544 1.5270863771438599 4.897102355957031 0.7257745349539734 1.7553097009658813 37.81461309796129 66.66704951073444 25.082265557948475 46.224199659442945 73.99709015844806 151.25495331981296 CONFLICT 0.5652173913043478 0.43478260869565216 0.0 GO:0050708 6 regulation of protein secretion 128 139 4 4 4 4 4 4 65 135 2343 0.67668 0.52596 0.78842 2.88 78968;24367;29657;25649 srebf1;fgg;arntl;apoa2 SREBF1_32750;FGG_8639;ARNTL_8086;APOA2_33095 55.7047 59.20035 11.2357 37.80234692088134 60.05569716372797 30.61883586874777 33.4259025 38.7107 4.94421 22.03353494536661 37.783518334005045 17.744799770284953 153.07987500000002 130.1822 24.5771 137.73613166837944 147.40469076574308 107.33423401630728 11.2357;93.1824;38.2177;80.183 4.94421;51.338;27.1236;50.2978 24.5771;327.378;63.2034;197.161 2 2 2 78968;25649 SREBF1_32750;APOA2_33095 45.70935 45.70935 48.75310337450326 27.621005 27.621005 32.06983104015439 110.86905 110.86905 122.03524601362099 11.2357;80.183 4.94421;50.2978 24.5771;197.161 2 24367;29657 FGG_8639;ARNTL_8086 65.70005 65.70005 38.86591209588424 39.2308 39.2308 17.122166442363515 195.2907 195.2907 186.79965107724368 93.1824;38.2177 51.338;27.1236 327.378;63.2034 0 Exp 2,1(0.25);Hill,1(0.25);Linear,1(0.25);Power,1(0.25) 2.6937701494637705 11.634690403938293 1.9088982343673706 4.897102355957031 1.3946028809967155 2.414344906806946 18.658400017536287 92.75099998246372 11.833038253540725 55.01876674645929 18.09846596498815 288.0612840350119 CONFLICT 0.5 0.5 0.0 GO:0007017 3 microtubule-based process 97 110 7 7 7 4 4 4 65 106 2372 0.82492 0.34793 0.53949 3.64 24587;293502;303575;289054 nefh;kif22;kif18b;aspm NEFH_33218;KIF22_8963;KIF18B_32882;ASPM_8092 26.639400000000002 11.7813 3.6768 35.34644537102234 41.05192158388784 40.608244331164734 14.257132499999999 8.241045 1.12034 17.12362391770966 21.10587276021863 19.596576272079137 79.54677500000001 21.148600000000002 11.7489 123.19228625730793 130.25944117157798 141.6340465283449 79.3182;13.2391;3.6768;10.3235 39.4261;9.02099;1.12034;7.4611 264.141;25.4349;11.7489;16.8623 3 1 3 293502;303575;289054 KIF22_8963;KIF18B_32882;ASPM_8092 9.0798 10.3235 4.90096802580878 5.867476666666666 7.4611 4.184470588023452 18.01536666666667 16.8623 6.915476921610919 13.2391;3.6768;10.3235 9.02099;1.12034;7.4611 25.4349;11.7489;16.8623 1 24587 NEFH_33218 79.3182 79.3182 39.4261 39.4261 264.141 264.141 79.3182 39.4261 264.141 0 Exp 2,1(0.25);Exp 4,1(0.25);Poly 2,2(0.5) 1.6948574916451677 6.7981730699539185 1.5452834367752075 1.8689792156219482 0.14596181622556195 1.6919552087783813 -8.000116463601895 61.27891646360189 -2.524018939355466 31.038283939355466 -41.18166553216176 200.2752155321618 UP 0.75 0.25 0.0 GO:0010883 4 regulation of lipid storage 20 22 2 2 2 2 2 2 67 20 2458 0.97973 0.1181 0.1181 9.09 78968;58827 srebf1;mest SREBF1_32750;MEST_9219 54.076449999999994 54.076449999999994 11.2357 60.58596967223518 68.83587117940199 56.87687310342439 30.839755 30.839755 4.94421 36.62183094404279 39.761243426910305 34.37982824551427 178.03455000000002 178.03455000000002 24.5771 217.02160703719113 230.90344556478408 203.73546005672384 0.5 54.076449999999994 11.2357;96.9172 4.94421;56.7353 24.5771;331.492 1 1 1 78968 SREBF1_32750 11.2357 11.2357 4.94421 4.94421 24.5771 24.5771 11.2357 4.94421 24.5771 1 58827 MEST_9219 96.9172 96.9172 56.7353 56.7353 331.492 331.492 96.9172 56.7353 331.492 0 Hill,1(0.5);Linear,1(0.5) 2.391451794675786 4.8588902950286865 2.0014708042144775 2.857419490814209 0.6052471206423891 2.4294451475143433 -29.89141999999999 138.04432 -19.9155132 81.59502320000001 -122.74205199999997 478.811152 CONFLICT 0.5 0.5 0.0 GO:0006094 7 gluconeogenesis 10 13 3 3 3 3 3 3 66 10 2468 0.99971 0.0044801 0.0044801 23.08 25044;362282;299691 sds;pck1;cry1 SDS_9798;PCK1_9439;CRY1_8386 35.836256666666664 37.2548 5.51457 29.637886581597442 42.87570246643495 21.188653785857298 22.215446666666665 21.8798 1.34064 21.04463759085752 26.693793169767602 15.572485623553737 80.1084 73.8251 39.6721 43.91637075590378 87.20393411027057 34.84541555180466 0.0 5.51457 0.5 21.384685 64.7394;5.51457;37.2548 43.4259;1.34064;21.8798 126.828;39.6721;73.8251 1 2 1 362282 PCK1_9439 5.51457 5.51457 1.34064 1.34064 39.6721 39.6721 5.51457 1.34064 39.6721 2 25044;299691 SDS_9798;CRY1_8386 50.9971 50.9971 19.434547038199792 32.65285 32.65285 15.23539341812346 100.32655 100.32655 37.47871001255251 64.7394;37.2548 43.4259;21.8798 126.828;73.8251 0 Exp 2,1(0.34);Hill,1(0.34);Linear,1(0.34) 2.0307989182348236 6.125105619430542 1.8622472286224365 2.3449018001556396 0.2640521351164708 1.9179565906524658 2.2978307463167837 69.37468258701657 -1.5988026023695632 46.02969593570289 30.412348183605204 129.80445181639482 DOWN 0.3333333333333333 0.6666666666666666 0.0