Gene Ontology Analyses GO Category: BP GO File Creation Date: 07/15/20 Deduplicate Gene Sets: true Data Source: Liver_PFHxSAm_Female Work Source: Liver_PFHxSAm_Female_williams_0.05_NOMTC_foldfilter1.5_BMD BMDExpress2 Version: BMDExpress 2.30.0507 BETA Timestamp (Start Time): 02/12/2021 22:59.39 Remove Promiscuous Probes: true Remove BMD > Highest Dose from Category Descriptive Statistics: true Remove BMD with p-Value < Cutoff: 0.1 Remove genes with BMDU/BMDL >: 40.0 Identify conflicting probe sets: 0.5 Category Count: 2536 Total Run Time: 0 seconds GO/Pathway/Gene Set/Gene ID GO Level GO/Pathway/Gene Set/Gene Name All Genes (Expression Data) All Genes (Platform) Input Genes Genes with BMD <= Highest Dose Genes with BMD p-Value >= Genes with BMDU/BMDL <= Genes That Passed All Filters Fisher's A Parameter Fisher's B Parameter Fisher's C Parameter Fisher's D Parameter Fisher's Exact Left P-Value Fisher's Exact Right P-Value Fisher's Exact Two Tail Percentage Entrez Gene IDs Gene Symbols Probe IDs Genes with Conflicting Probesets BMD Mean BMD Median BMD Minimum BMD Standard Deviation BMD wMean BMD wSD BMDL Mean BMDL Median BMDL Minimum BMDL Standard Deviation BMDL wMean BMDL wSD BMDU Mean BMDU Median BMDU Minimum BMDU Standard Deviation BMDU wMean BMDU wSD 5th Percentile Index BMD at 5th Percentile of Total Genes 10th Percentile Index BMD at 10th Percentile of Total Genes BMD List BMDL List BMDU List Probes with Adverse Direction Up Probes with Adverse Direction Down Genes with Adverse Direction Up Genes Up List Genes Up Probes List Genes Up BMD Mean Genes Up BMD Median Genes Up SD Genes Up BMDL Mean Genes Up BMDL Median Genes Up BMDL SD Genes Up BMDU Mean Genes Up BMDU Median Genes Up BMDU SD BMD list (up) BMDL List (up) BMDU List (up) Genes with Adverse Direction Down Genes Down List Genes Down Probes List Genes Down BMD Mean Genes Down BMD Median Genes Down SD Genes Down BMDL Mean Genes Down BMDL Median Genes Down BMDL SD Genes Down BMDU Mean Genes Down BMDU Median Genes Down BMDU SD BMD list (down) BMDL List (down) BMDU List (down) Genes with Adverse Conflict Count Genes Conflict List Genes Conflict Probes List BMD list (Conflict) BMDL list (Conflict) BMDU list (Conflict) Model Counts Mean Fold Change Total Fold Change Min Fold Change Max Fold Change Standard Deviation Fold Change Median Fold Change Lower bound of the 95% confidence interval - BMD Upper bound of the 95% confidence interval - BMD Lower bound of the 95% confidence interval - BMDL Upper bound of the 95% confidence interval - BMDL Lower bound of the 95% confidence interval - BMDU Upper bound of the 95% confidence interval - BMDU Overall Direction Percent Genes With Overall Direction Up Percent Genes With Overall Direction Down Percent Genes With Overall Direction Conflict GO:0000077 8 DNA damage checkpoint 17 18 1 1 0 1 0 0 96 18 2433 0.49961 1.0 1.0 0.0 0 0 0 0 0 GO:0000165 8 MAPK cascade 43 45 1 1 0 1 0 0 96 45 2406 0.17477 1.0 0.4141 0.0 0 0 0 0 0 GO:0000290 9 deadenylation-dependent decapping of nuclear-transcribed mRNA 3 3 1 0 1 1 0 0 96 3 2448 0.89109 1.0 1.0 0.0 0 0 0 0 0 GO:0000902 4 cell morphogenesis 62 65 1 1 0 1 0 0 96 65 2386 0.079671 1.0 0.17538 0.0 0 0 0 0 0 GO:0000956 8 nuclear-transcribed mRNA catabolic process 15 16 1 0 1 1 0 0 96 16 2435 0.53979 1.0 1.0 0.0 0 0 0 0 0 GO:0001579 8 medium-chain fatty acid transport 2 2 1 1 0 1 0 0 96 2 2449 0.92602 1.0 1.0 0.0 0 0 0 0 0 GO:0001654 6 eye development 16 16 1 1 0 1 0 0 96 16 2435 0.53979 1.0 1.0 0.0 0 0 0 0 0 GO:0001661 8 conditioned taste aversion 2 2 1 1 0 1 0 0 96 2 2449 0.92602 1.0 1.0 0.0 0 0 0 0 0 GO:0001678 6 cellular glucose homeostasis 56 60 1 1 0 1 0 0 96 60 2391 0.097017 1.0 0.17016 0.0 0 0 0 0 0 GO:0001692 5 histamine metabolic process 1 1 1 1 0 1 0 0 96 1 2450 0.96231 1.0 1.0 0.0 0 0 0 0 0 GO:0001694 6 histamine biosynthetic process 1 1 1 1 0 1 0 0 96 1 2450 0.96231 1.0 1.0 0.0 0 0 0 0 0 GO:0001935 5 endothelial cell proliferation 7 8 1 1 0 1 0 0 96 8 2443 0.73507 1.0 1.0 0.0 0 0 0 0 0 GO:0002009 5 morphogenesis of an epithelium 84 87 2 2 0 1 0 0 96 87 2364 0.033325 1.0 0.076575 0.0 0 0 0 0 0 GO:0002069 6 columnar/cuboidal epithelial cell maturation 3 4 1 1 0 1 0 0 96 4 2447 0.85747 1.0 1.0 0.0 0 0 0 0 0 GO:0002070 5 epithelial cell maturation 7 8 1 1 0 1 0 0 96 8 2443 0.73507 1.0 1.0 0.0 0 0 0 0 0 GO:0002072 6 optic cup morphogenesis involved in camera-type eye development 1 1 1 1 0 1 0 0 96 1 2450 0.96231 1.0 1.0 0.0 0 0 0 0 0 GO:0002138 7 retinoic acid biosynthetic process 3 3 1 1 0 1 0 0 96 3 2448 0.89109 1.0 1.0 0.0 0 0 0 0 0 GO:0003002 4 regionalization 36 40 1 1 0 1 0 0 96 40 2411 0.21248 1.0 0.40203 0.0 0 0 0 0 0 GO:0003159 6 morphogenesis of an endothelium 6 7 1 1 0 0 0 0 96 7 2444 0.76394 1.0 1.0 0.0 0 0 0 0 0 GO:0006401 6 RNA catabolic process 23 25 1 0 1 1 0 0 96 25 2426 0.38093 1.0 1.0 0.0 0 0 0 0 0 GO:0006402 7 mRNA catabolic process 19 21 1 0 1 1 0 0 96 21 2430 0.44483 1.0 1.0 0.0 0 0 0 0 0 GO:0006547 7 histidine metabolic process 2 2 1 1 0 1 0 0 96 2 2449 0.92602 1.0 1.0 0.0 0 0 0 0 0 GO:0006548 7 histidine catabolic process 2 2 1 1 0 1 0 0 96 2 2449 0.92602 1.0 1.0 0.0 0 0 0 0 0 GO:0006576 6 cellular biogenic amine metabolic process 13 15 1 1 0 1 0 0 96 15 2436 0.56106 1.0 1.0 0.0 0 0 0 0 0 GO:0006606 6 protein import into nucleus 22 23 1 1 0 1 0 0 96 23 2428 0.41165 1.0 1.0 0.0 0 0 0 0 0 GO:0006739 3 NADP metabolic process 12 12 1 0 1 1 0 0 96 12 2439 0.62999 1.0 1.0 0.0 0 0 0 0 0 GO:0006913 6 nucleocytoplasmic transport 37 41 1 1 0 1 0 0 96 41 2410 0.20434 1.0 0.40364 0.0 0 0 0 0 0 GO:0006935 4 chemotaxis 73 79 1 1 0 1 0 0 96 79 2372 0.045795 1.0 0.073158 0.0 0 0 0 0 0 GO:0006977 8 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest 5 5 1 1 0 1 0 0 96 5 2446 0.8251 1.0 1.0 0.0 0 0 0 0 0 GO:0006978 8 DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator 4 4 1 1 0 1 0 0 96 4 2447 0.85747 1.0 1.0 0.0 0 0 0 0 0 GO:0007031 6 peroxisome organization 3 3 1 1 0 1 0 0 96 3 2448 0.89109 1.0 1.0 0.0 0 0 0 0 0 GO:0007043 7 cell-cell junction assembly 20 20 1 1 0 1 0 0 96 20 2431 0.46239 1.0 1.0 0.0 0 0 0 0 0 GO:0007050 6 cell cycle arrest 22 23 1 1 0 1 0 0 96 23 2428 0.41165 1.0 1.0 0.0 0 0 0 0 0 GO:0007095 9 mitotic G2 DNA damage checkpoint 5 6 1 1 0 1 0 0 96 6 2445 0.79394 1.0 1.0 0.0 0 0 0 0 0 GO:0007179 8 transforming growth factor beta receptor signaling pathway 27 29 2 2 0 2 0 0 96 29 2422 0.32613 1.0 0.62529 0.0 0 0 0 0 0 GO:0007229 6 integrin-mediated signaling pathway 28 29 1 1 0 1 0 0 96 29 2422 0.32613 1.0 0.62529 0.0 0 0 0 0 0 GO:0007389 3 pattern specification process 49 53 1 1 0 1 0 0 96 53 2398 0.12774 1.0 0.26468 0.0 0 0 0 0 0 GO:0007399 5 nervous system development 36 37 3 3 0 3 0 0 96 37 2414 0.23886 1.0 0.40003 0.0 0 0 0 0 0 GO:0007409 9 axonogenesis 28 30 1 1 0 1 0 0 96 30 2421 0.31369 1.0 0.62699 0.0 0 0 0 0 0 GO:0007423 5 sensory organ development 31 32 1 1 0 1 0 0 96 32 2419 0.29021 1.0 0.6316 0.0 0 0 0 0 0 GO:0007494 6 midgut development 10 10 1 1 0 1 0 0 96 10 2441 0.68052 1.0 1.0 0.0 0 0 0 0 0 GO:0007569 4 cell aging 31 33 1 1 0 1 0 0 96 33 2418 0.27914 1.0 0.63443 0.0 0 0 0 0 0 GO:0008299 5 isoprenoid biosynthetic process 14 14 2 1 1 2 0 0 96 14 2437 0.58316 1.0 1.0 0.0 0 0 0 0 0 GO:0008306 7 associative learning 20 22 1 1 0 1 0 0 96 22 2429 0.42792 1.0 1.0 0.0 0 0 0 0 0 GO:0008543 8 fibroblast growth factor receptor signaling pathway 12 13 1 1 0 1 0 0 96 13 2438 0.60613 1.0 1.0 0.0 0 0 0 0 0 GO:0008630 7 intrinsic apoptotic signaling pathway in response to DNA damage 37 38 1 1 0 1 0 0 96 38 2413 0.22972 1.0 0.40021 0.0 0 0 0 0 0 GO:0009072 6 aromatic amino acid family metabolic process 16 17 1 1 0 1 0 0 96 17 2434 0.51932 1.0 1.0 0.0 0 0 0 0 0 GO:0009074 6 aromatic amino acid family catabolic process 13 13 1 1 0 1 0 0 96 13 2438 0.60613 1.0 1.0 0.0 0 0 0 0 0 GO:0009240 6 isopentenyl diphosphate biosynthetic process 2 2 1 0 1 1 0 0 96 2 2449 0.92602 1.0 1.0 0.0 0 0 0 0 0 GO:0009308 5 amine metabolic process 16 18 1 1 0 1 0 0 96 18 2433 0.49961 1.0 1.0 0.0 0 0 0 0 0 GO:0009309 6 amine biosynthetic process 2 3 1 1 0 1 0 0 96 3 2448 0.89109 1.0 1.0 0.0 0 0 0 0 0 GO:0009411 6 response to UV 49 51 1 1 0 1 0 0 96 51 2400 0.13817 1.0 0.2617 0.0 0 0 0 0 0 GO:0009629 4 response to gravity 8 9 1 1 0 1 0 0 96 9 2442 0.70728 1.0 1.0 0.0 0 0 0 0 0 GO:0009648 6 photoperiodism 7 8 1 1 0 1 0 0 96 8 2443 0.73507 1.0 1.0 0.0 0 0 0 0 0 GO:0009649 4 entrainment of circadian clock 7 7 1 1 0 1 0 0 96 7 2444 0.76394 1.0 1.0 0.0 0 0 0 0 0 GO:0009887 4 animal organ morphogenesis 110 116 1 1 0 1 0 0 96 116 2335 0.010435 1.0 0.021088 0.0 0 0 0 0 0 GO:0009952 5 anterior/posterior pattern specification 22 26 1 1 0 1 0 0 96 26 2425 0.36643 1.0 0.623 0.0 0 0 0 0 0 GO:0010165 6 response to X-ray 13 13 1 1 0 1 0 0 96 13 2438 0.60613 1.0 1.0 0.0 0 0 0 0 0 GO:0010224 7 response to UV-B 7 8 1 1 0 1 0 0 96 8 2443 0.73507 1.0 1.0 0.0 0 0 0 0 0 GO:0010332 6 response to gamma radiation 40 40 1 1 0 1 0 0 96 40 2411 0.21248 1.0 0.40203 0.0 0 0 0 0 0 GO:0010389 8 regulation of G2/M transition of mitotic cell cycle 26 27 1 1 0 1 0 0 96 27 2424 0.35247 1.0 0.62325 0.0 0 0 0 0 0 GO:0010470 6 regulation of gastrulation 12 12 1 1 0 1 0 0 96 12 2439 0.62999 1.0 1.0 0.0 0 0 0 0 0 GO:0010608 7 posttranscriptional regulation of gene expression 70 78 1 0 1 1 0 0 96 78 2373 0.047648 1.0 0.1187 0.0 0 0 0 0 0 GO:0010631 6 epithelial cell migration 28 30 1 1 0 1 0 0 96 30 2421 0.31369 1.0 0.62699 0.0 0 0 0 0 0 GO:0010769 7 regulation of cell morphogenesis involved in differentiation 72 76 1 1 0 1 0 0 96 76 2375 0.051578 1.0 0.11576 0.0 0 0 0 0 0 GO:0010770 8 positive regulation of cell morphogenesis involved in differentiation 40 44 1 1 0 1 0 0 96 44 2407 0.18174 1.0 0.41092 0.0 0 0 0 0 0 GO:0010803 7 regulation of tumor necrosis factor-mediated signaling pathway 11 11 1 1 0 1 0 0 96 11 2440 0.65477 1.0 1.0 0.0 0 0 0 0 0 GO:0010804 8 negative regulation of tumor necrosis factor-mediated signaling pathway 4 4 1 1 0 1 0 0 96 4 2447 0.85747 1.0 1.0 0.0 0 0 0 0 0 GO:0010810 6 regulation of cell-substrate adhesion 67 71 1 1 0 1 0 0 96 71 2380 0.062864 1.0 0.11167 0.0 0 0 0 0 0 GO:0010811 7 positive regulation of cell-substrate adhesion 40 43 1 1 0 1 0 0 96 43 2408 0.18898 1.0 0.4081 0.0 0 0 0 0 0 GO:0010827 6 regulation of glucose transmembrane transport 28 31 2 2 0 2 0 0 96 31 2420 0.30173 1.0 0.6291 0.0 0 0 0 0 0 GO:0010828 7 positive regulation of glucose transmembrane transport 19 20 1 1 0 1 0 0 96 20 2431 0.46239 1.0 1.0 0.0 0 0 0 0 0 GO:0010896 7 regulation of triglyceride catabolic process 9 11 2 2 0 2 0 0 96 11 2440 0.65477 1.0 1.0 0.0 0 0 0 0 0 GO:0010898 8 positive regulation of triglyceride catabolic process 5 7 2 2 0 2 0 0 96 7 2444 0.76394 1.0 1.0 0.0 0 0 0 0 0 GO:0010948 7 negative regulation of cell cycle process 56 60 1 1 0 1 0 0 96 60 2391 0.097017 1.0 0.17016 0.0 0 0 0 0 0 GO:0010972 9 negative regulation of G2/M transition of mitotic cell cycle 12 13 1 1 0 1 0 0 96 13 2438 0.60613 1.0 1.0 0.0 0 0 0 0 0 GO:0014012 8 peripheral nervous system axon regeneration 7 7 1 1 0 1 0 0 96 7 2444 0.76394 1.0 1.0 0.0 0 0 0 0 0 GO:0016102 7 diterpenoid biosynthetic process 3 3 1 1 0 1 0 0 96 3 2448 0.89109 1.0 1.0 0.0 0 0 0 0 0 GO:0016114 6 terpenoid biosynthetic process 8 8 1 1 0 1 0 0 96 8 2443 0.73507 1.0 1.0 0.0 0 0 0 0 0 GO:0016331 5 morphogenesis of embryonic epithelium 6 6 1 1 0 1 0 0 96 6 2445 0.79394 1.0 1.0 0.0 0 0 0 0 0 GO:0016557 6 peroxisome membrane biogenesis 1 1 1 1 0 1 0 0 96 1 2450 0.96231 1.0 1.0 0.0 0 0 0 0 0 GO:0018107 8 peptidyl-threonine phosphorylation 18 18 1 1 0 0 0 0 96 18 2433 0.49961 1.0 1.0 0.0 0 0 0 0 0 GO:0018210 8 peptidyl-threonine modification 19 19 1 1 0 0 0 0 96 19 2432 0.48065 1.0 1.0 0.0 0 0 0 0 0 GO:0019626 7 short-chain fatty acid catabolic process 3 3 1 1 0 1 0 0 96 3 2448 0.89109 1.0 1.0 0.0 0 0 0 0 0 GO:0021540 12 corpus callosum morphogenesis 3 3 1 1 0 1 0 0 96 3 2448 0.89109 1.0 1.0 0.0 0 0 0 0 0 GO:0021670 4 lateral ventricle development 1 1 1 1 0 1 0 0 96 1 2450 0.96231 1.0 1.0 0.0 0 0 0 0 0 GO:0021952 11 central nervous system projection neuron axonogenesis 7 7 1 1 0 1 0 0 96 7 2444 0.76394 1.0 1.0 0.0 0 0 0 0 0 GO:0021955 10 central nervous system neuron axonogenesis 9 10 1 1 0 1 0 0 96 10 2441 0.68052 1.0 1.0 0.0 0 0 0 0 0 GO:0021960 12 anterior commissure morphogenesis 1 1 1 1 0 1 0 0 96 1 2450 0.96231 1.0 1.0 0.0 0 0 0 0 0 GO:0023014 7 signal transduction by protein phosphorylation 49 51 1 1 0 1 0 0 96 51 2400 0.13817 1.0 0.2617 0.0 0 0 0 0 0 GO:0030279 6 negative regulation of ossification 16 19 2 1 1 2 0 0 96 19 2432 0.48065 1.0 1.0 0.0 0 0 0 0 0 GO:0030325 6 adrenal gland development 11 14 1 1 0 1 0 0 96 14 2437 0.58316 1.0 1.0 0.0 0 0 0 0 0 GO:0030330 7 DNA damage response, signal transduction by p53 class mediator 13 14 1 1 0 1 0 0 96 14 2437 0.58316 1.0 1.0 0.0 0 0 0 0 0 GO:0030431 3 sleep 4 4 1 1 0 1 0 0 96 4 2447 0.85747 1.0 1.0 0.0 0 0 0 0 0 GO:0030500 6 regulation of bone mineralization 18 20 1 1 0 1 0 0 96 20 2431 0.46239 1.0 1.0 0.0 0 0 0 0 0 GO:0030502 7 negative regulation of bone mineralization 4 5 1 1 0 1 0 0 96 5 2446 0.8251 1.0 1.0 0.0 0 0 0 0 0 GO:0030968 5 endoplasmic reticulum unfolded protein response 19 20 1 1 0 1 0 0 96 20 2431 0.46239 1.0 1.0 0.0 0 0 0 0 0 GO:0031330 7 negative regulation of cellular catabolic process 57 58 1 0 1 1 0 0 96 58 2393 0.10496 1.0 0.17 0.0 0 0 0 0 0 GO:0031572 9 G2 DNA damage checkpoint 5 6 1 1 0 1 0 0 96 6 2445 0.79394 1.0 1.0 0.0 0 0 0 0 0 GO:0032092 6 positive regulation of protein binding 30 33 1 1 0 1 0 0 96 33 2418 0.27914 1.0 0.63443 0.0 0 0 0 0 0 GO:0032231 6 regulation of actin filament bundle assembly 27 30 1 1 0 1 0 0 96 30 2421 0.31369 1.0 0.62699 0.0 0 0 0 0 0 GO:0032233 7 positive regulation of actin filament bundle assembly 21 24 1 1 0 1 0 0 96 24 2427 0.396 1.0 1.0 0.0 0 0 0 0 0 GO:0032388 6 positive regulation of intracellular transport 64 68 1 1 0 1 0 0 96 68 2383 0.070776 1.0 0.18155 0.0 0 0 0 0 0 GO:0032467 7 positive regulation of cytokinesis 11 12 1 1 0 1 0 0 96 12 2439 0.62999 1.0 1.0 0.0 0 0 0 0 0 GO:0032489 10 regulation of Cdc42 protein signal transduction 4 5 1 1 0 1 0 0 96 5 2446 0.8251 1.0 1.0 0.0 0 0 0 0 0 GO:0032691 8 negative regulation of interleukin-1 beta production 6 6 1 1 0 1 0 0 96 6 2445 0.79394 1.0 1.0 0.0 0 0 0 0 0 GO:0032692 7 negative regulation of interleukin-1 production 9 9 1 1 0 1 0 0 96 9 2442 0.70728 1.0 1.0 0.0 0 0 0 0 0 GO:0032890 6 regulation of organic acid transport 33 35 1 1 0 1 0 0 96 35 2416 0.25822 1.0 0.64103 0.0 0 0 0 0 0 GO:0032922 6 circadian regulation of gene expression 22 23 2 1 1 2 0 0 96 23 2428 0.41165 1.0 1.0 0.0 0 0 0 0 0 GO:0032925 7 regulation of activin receptor signaling pathway 4 4 1 1 0 0 0 0 96 4 2447 0.85747 1.0 1.0 0.0 0 0 0 0 0 GO:0032927 8 positive regulation of activin receptor signaling pathway 2 2 1 1 0 0 0 0 96 2 2449 0.92602 1.0 1.0 0.0 0 0 0 0 0 GO:0032954 7 regulation of cytokinetic process 3 3 1 1 0 1 0 0 96 3 2448 0.89109 1.0 1.0 0.0 0 0 0 0 0 GO:0032989 4 cellular component morphogenesis 59 63 1 1 0 1 0 0 96 63 2388 0.086207 1.0 0.1725 0.0 0 0 0 0 0 GO:0032990 5 cell part morphogenesis 59 63 1 1 0 1 0 0 96 63 2388 0.086207 1.0 0.1725 0.0 0 0 0 0 0 GO:0033211 6 adiponectin-activated signaling pathway 2 2 1 1 0 0 0 0 96 2 2449 0.92602 1.0 1.0 0.0 0 0 0 0 0 GO:0033561 5 regulation of water loss via skin 8 8 1 1 0 1 0 0 96 8 2443 0.73507 1.0 1.0 0.0 0 0 0 0 0 GO:0033962 7 cytoplasmic mRNA processing body assembly 3 3 1 0 1 1 0 0 96 3 2448 0.89109 1.0 1.0 0.0 0 0 0 0 0 GO:0034103 5 regulation of tissue remodeling 28 28 1 1 0 1 0 0 96 28 2423 0.33905 1.0 0.62403 0.0 0 0 0 0 0 GO:0034105 6 positive regulation of tissue remodeling 16 16 1 1 0 1 0 0 96 16 2435 0.53979 1.0 1.0 0.0 0 0 0 0 0 GO:0034114 7 regulation of heterotypic cell-cell adhesion 12 13 1 1 0 1 0 0 96 13 2438 0.60613 1.0 1.0 0.0 0 0 0 0 0 GO:0034115 8 negative regulation of heterotypic cell-cell adhesion 4 4 1 1 0 1 0 0 96 4 2447 0.85747 1.0 1.0 0.0 0 0 0 0 0 GO:0034198 6 cellular response to amino acid starvation 13 15 1 1 0 1 0 0 96 15 2436 0.56106 1.0 1.0 0.0 0 0 0 0 0 GO:0034329 6 cell junction assembly 40 41 1 1 0 1 0 0 96 41 2410 0.20434 1.0 0.40364 0.0 0 0 0 0 0 GO:0034330 5 cell junction organization 75 80 1 1 0 1 0 0 96 80 2371 0.044014 1.0 0.073101 0.0 0 0 0 0 0 GO:0034372 9 very-low-density lipoprotein particle remodeling 4 4 1 1 0 1 0 0 96 4 2447 0.85747 1.0 1.0 0.0 0 0 0 0 0 GO:0034379 8 very-low-density lipoprotein particle assembly 3 3 1 1 0 1 0 0 96 3 2448 0.89109 1.0 1.0 0.0 0 0 0 0 0 GO:0034401 6 chromatin organization involved in regulation of transcription 19 22 1 1 0 1 0 0 96 22 2429 0.42792 1.0 1.0 0.0 0 0 0 0 0 GO:0034433 6 steroid esterification 2 2 1 1 0 1 0 0 96 2 2449 0.92602 1.0 1.0 0.0 0 0 0 0 0 GO:0034434 7 sterol esterification 2 2 1 1 0 1 0 0 96 2 2449 0.92602 1.0 1.0 0.0 0 0 0 0 0 GO:0034435 8 cholesterol esterification 2 2 1 1 0 1 0 0 96 2 2449 0.92602 1.0 1.0 0.0 0 0 0 0 0 GO:0034504 7 protein localization to nucleus 39 40 1 1 0 1 0 0 96 40 2411 0.21248 1.0 0.40203 0.0 0 0 0 0 0 GO:0034644 7 cellular response to UV 32 34 1 1 0 1 0 0 96 34 2417 0.26848 1.0 0.63759 0.0 0 0 0 0 0 GO:0034655 5 nucleobase-containing compound catabolic process 33 39 1 0 1 1 0 0 96 39 2412 0.22093 1.0 0.40088 0.0 0 0 0 0 0 GO:0034762 5 regulation of transmembrane transport 122 128 2 2 0 2 0 0 96 128 2323 0.0064274 1.0 0.014048 0.0 0 0 0 0 0 GO:0034764 6 positive regulation of transmembrane transport 60 63 1 1 0 1 0 0 96 63 2388 0.086207 1.0 0.1725 0.0 0 0 0 0 0 GO:0034976 5 response to endoplasmic reticulum stress 55 58 2 2 0 2 0 0 96 58 2393 0.10496 1.0 0.17 0.0 0 0 0 0 0 GO:0035023 9 regulation of Rho protein signal transduction 18 19 1 1 0 1 0 0 96 19 2432 0.48065 1.0 1.0 0.0 0 0 0 0 0 GO:0035025 10 positive regulation of Rho protein signal transduction 9 9 1 1 0 1 0 0 96 9 2442 0.70728 1.0 1.0 0.0 0 0 0 0 0 GO:0035295 4 tube development 61 65 1 1 0 1 0 0 96 65 2386 0.079671 1.0 0.17538 0.0 0 0 0 0 0 GO:0035376 8 sterol import 4 4 1 1 0 1 0 0 96 4 2447 0.85747 1.0 1.0 0.0 0 0 0 0 0 GO:0035634 6 response to stilbenoid 13 15 1 0 1 1 0 0 96 15 2436 0.56106 1.0 1.0 0.0 0 0 0 0 0 GO:0035914 5 skeletal muscle cell differentiation 14 15 1 1 0 1 0 0 96 15 2436 0.56106 1.0 1.0 0.0 0 0 0 0 0 GO:0036314 5 response to sterol 18 18 1 1 0 1 0 0 96 18 2433 0.49961 1.0 1.0 0.0 0 0 0 0 0 GO:0036315 6 cellular response to sterol 9 9 1 1 0 1 0 0 96 9 2442 0.70728 1.0 1.0 0.0 0 0 0 0 0 GO:0040029 7 regulation of gene expression, epigenetic 21 26 1 1 0 1 0 0 96 26 2425 0.36643 1.0 0.623 0.0 0 0 0 0 0 GO:0042136 5 neurotransmitter biosynthetic process 14 17 1 1 0 1 0 0 96 17 2434 0.51932 1.0 1.0 0.0 0 0 0 0 0 GO:0042158 6 lipoprotein biosynthetic process 3 3 1 1 0 1 0 0 96 3 2448 0.89109 1.0 1.0 0.0 0 0 0 0 0 GO:0042306 8 regulation of protein import into nucleus 30 33 1 1 0 1 0 0 96 33 2418 0.27914 1.0 0.63443 0.0 0 0 0 0 0 GO:0042307 8 positive regulation of protein import into nucleus 21 22 1 1 0 1 0 0 96 22 2429 0.42792 1.0 1.0 0.0 0 0 0 0 0 GO:0042330 3 taxis 75 81 1 1 0 1 0 0 96 81 2370 0.042301 1.0 0.073185 0.0 0 0 0 0 0 GO:0042401 7 cellular biogenic amine biosynthetic process 2 3 1 1 0 1 0 0 96 3 2448 0.89109 1.0 1.0 0.0 0 0 0 0 0 GO:0042572 8 retinol metabolic process 8 10 1 1 0 1 0 0 96 10 2441 0.68052 1.0 1.0 0.0 0 0 0 0 0 GO:0042698 3 ovulation cycle 18 20 1 1 0 1 0 0 96 20 2431 0.46239 1.0 1.0 0.0 0 0 0 0 0 GO:0042770 6 signal transduction in response to DNA damage 22 24 1 1 0 1 0 0 96 24 2427 0.396 1.0 1.0 0.0 0 0 0 0 0 GO:0042771 8 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 12 12 1 1 0 1 0 0 96 12 2439 0.62999 1.0 1.0 0.0 0 0 0 0 0 GO:0042772 7 DNA damage response, signal transduction resulting in transcription 4 4 1 1 0 1 0 0 96 4 2447 0.85747 1.0 1.0 0.0 0 0 0 0 0 GO:0042904 8 9-cis-retinoic acid biosynthetic process 2 2 1 1 0 1 0 0 96 2 2449 0.92602 1.0 1.0 0.0 0 0 0 0 0 GO:0042905 9 9-cis-retinoic acid metabolic process 2 2 1 1 0 1 0 0 96 2 2449 0.92602 1.0 1.0 0.0 0 0 0 0 0 GO:0043010 7 camera-type eye development 12 12 1 1 0 1 0 0 96 12 2439 0.62999 1.0 1.0 0.0 0 0 0 0 0 GO:0043087 6 regulation of GTPase activity 76 81 1 1 0 1 0 0 96 81 2370 0.042301 1.0 0.073185 0.0 0 0 0 0 0 GO:0043153 5 entrainment of circadian clock by photoperiod 7 7 1 1 0 1 0 0 96 7 2444 0.76394 1.0 1.0 0.0 0 0 0 0 0 GO:0043269 6 regulation of ion transport 174 184 2 2 0 2 0 0 96 184 2267 6.48E-4 1.0 0.0010163 0.0 0 0 0 0 0 GO:0043270 6 positive regulation of ion transport 88 94 1 1 0 1 0 0 96 94 2357 0.025212 1.0 0.048592 0.0 0 0 0 0 0 GO:0043433 8 negative regulation of DNA-binding transcription factor activity 32 34 1 1 0 1 0 0 96 34 2417 0.26848 1.0 0.63759 0.0 0 0 0 0 0 GO:0043487 5 regulation of RNA stability 15 16 1 0 1 1 0 0 96 16 2435 0.53979 1.0 1.0 0.0 0 0 0 0 0 GO:0043488 6 regulation of mRNA stability 15 16 1 0 1 1 0 0 96 16 2435 0.53979 1.0 1.0 0.0 0 0 0 0 0 GO:0043489 6 RNA stabilization 10 10 1 0 1 1 0 0 96 10 2441 0.68052 1.0 1.0 0.0 0 0 0 0 0 GO:0043534 8 blood vessel endothelial cell migration 13 13 1 1 0 1 0 0 96 13 2438 0.60613 1.0 1.0 0.0 0 0 0 0 0 GO:0043542 7 endothelial cell migration 25 26 1 1 0 1 0 0 96 26 2425 0.36643 1.0 0.623 0.0 0 0 0 0 0 GO:0043547 7 positive regulation of GTPase activity 63 68 1 1 0 1 0 0 96 68 2383 0.070776 1.0 0.18155 0.0 0 0 0 0 0 GO:0044070 7 regulation of anion transport 43 45 2 2 0 2 0 0 96 45 2406 0.17477 1.0 0.4141 0.0 0 0 0 0 0 GO:0044085 4 cellular component biogenesis 15 18 1 1 0 1 0 0 96 18 2433 0.49961 1.0 1.0 0.0 0 0 0 0 0 GO:0044089 6 positive regulation of cellular component biogenesis 110 121 1 1 0 1 0 0 96 121 2330 0.0085297 1.0 0.013511 0.0 0 0 0 0 0 GO:0044091 5 membrane biogenesis 1 1 1 1 0 1 0 0 96 1 2450 0.96231 1.0 1.0 0.0 0 0 0 0 0 GO:0044106 5 cellular amine metabolic process 14 16 1 1 0 1 0 0 96 16 2435 0.53979 1.0 1.0 0.0 0 0 0 0 0 GO:0044270 5 cellular nitrogen compound catabolic process 51 59 2 1 1 2 0 0 96 59 2392 0.10091 1.0 0.16994 0.0 0 0 0 0 0 GO:0044375 6 regulation of peroxisome size 1 1 1 1 0 1 0 0 96 1 2450 0.96231 1.0 1.0 0.0 0 0 0 0 0 GO:0044773 9 mitotic DNA damage checkpoint 13 14 1 1 0 1 0 0 96 14 2437 0.58316 1.0 1.0 0.0 0 0 0 0 0 GO:0044818 8 mitotic G2/M transition checkpoint 9 10 1 1 0 1 0 0 96 10 2441 0.68052 1.0 1.0 0.0 0 0 0 0 0 GO:0044849 4 estrous cycle 13 15 1 1 0 1 0 0 96 15 2436 0.56106 1.0 1.0 0.0 0 0 0 0 0 GO:0045124 5 regulation of bone resorption 18 18 1 1 0 1 0 0 96 18 2433 0.49961 1.0 1.0 0.0 0 0 0 0 0 GO:0045216 6 cell-cell junction organization 33 33 1 1 0 1 0 0 96 33 2418 0.27914 1.0 0.63443 0.0 0 0 0 0 0 GO:0045599 7 negative regulation of fat cell differentiation 17 19 1 1 0 1 0 0 96 19 2432 0.48065 1.0 1.0 0.0 0 0 0 0 0 GO:0045668 7 negative regulation of osteoblast differentiation 7 8 1 0 1 1 0 0 96 8 2443 0.73507 1.0 1.0 0.0 0 0 0 0 0 GO:0045670 8 regulation of osteoclast differentiation 23 26 1 1 0 1 0 0 96 26 2425 0.36643 1.0 0.623 0.0 0 0 0 0 0 GO:0045672 9 positive regulation of osteoclast differentiation 11 14 1 1 0 1 0 0 96 14 2437 0.58316 1.0 1.0 0.0 0 0 0 0 0 GO:0045717 8 negative regulation of fatty acid biosynthetic process 10 10 1 1 0 1 0 0 96 10 2441 0.68052 1.0 1.0 0.0 0 0 0 0 0 GO:0045736 9 negative regulation of cyclin-dependent protein serine/threonine kinase activity 8 8 1 1 0 1 0 0 96 8 2443 0.73507 1.0 1.0 0.0 0 0 0 0 0 GO:0045780 6 positive regulation of bone resorption 11 11 1 1 0 1 0 0 96 11 2440 0.65477 1.0 1.0 0.0 0 0 0 0 0 GO:0045815 8 positive regulation of gene expression, epigenetic 7 7 1 1 0 1 0 0 96 7 2444 0.76394 1.0 1.0 0.0 0 0 0 0 0 GO:0045922 7 negative regulation of fatty acid metabolic process 13 15 1 1 0 1 0 0 96 15 2436 0.56106 1.0 1.0 0.0 0 0 0 0 0 GO:0046324 7 regulation of glucose import 21 24 1 1 0 1 0 0 96 24 2427 0.396 1.0 1.0 0.0 0 0 0 0 0 GO:0046326 8 positive regulation of glucose import 16 17 1 1 0 1 0 0 96 17 2434 0.51932 1.0 1.0 0.0 0 0 0 0 0 GO:0046490 6 isopentenyl diphosphate metabolic process 2 2 1 0 1 1 0 0 96 2 2449 0.92602 1.0 1.0 0.0 0 0 0 0 0 GO:0046578 8 regulation of Ras protein signal transduction 34 36 1 1 0 1 0 0 96 36 2415 0.24835 1.0 0.64474 0.0 0 0 0 0 0 GO:0046579 9 positive regulation of Ras protein signal transduction 15 16 1 1 0 1 0 0 96 16 2435 0.53979 1.0 1.0 0.0 0 0 0 0 0 GO:0046626 6 regulation of insulin receptor signaling pathway 27 27 1 1 0 1 0 0 96 27 2424 0.35247 1.0 0.62325 0.0 0 0 0 0 0 GO:0046627 7 negative regulation of insulin receptor signaling pathway 17 17 1 1 0 1 0 0 96 17 2434 0.51932 1.0 1.0 0.0 0 0 0 0 0 GO:0046685 4 response to arsenic-containing substance 19 20 1 1 0 1 0 0 96 20 2431 0.46239 1.0 1.0 0.0 0 0 0 0 0 GO:0046686 6 response to cadmium ion 39 43 1 1 0 1 0 0 96 43 2408 0.18898 1.0 0.4081 0.0 0 0 0 0 0 GO:0046822 7 regulation of nucleocytoplasmic transport 42 46 1 1 0 1 0 0 96 46 2405 0.16806 1.0 0.41762 0.0 0 0 0 0 0 GO:0046824 7 positive regulation of nucleocytoplasmic transport 25 27 1 1 0 1 0 0 96 27 2424 0.35247 1.0 0.62325 0.0 0 0 0 0 0 GO:0046850 6 regulation of bone remodeling 20 20 1 1 0 1 0 0 96 20 2431 0.46239 1.0 1.0 0.0 0 0 0 0 0 GO:0046852 7 positive regulation of bone remodeling 11 11 1 1 0 1 0 0 96 11 2440 0.65477 1.0 1.0 0.0 0 0 0 0 0 GO:0048048 6 embryonic eye morphogenesis 5 5 1 1 0 1 0 0 96 5 2446 0.8251 1.0 1.0 0.0 0 0 0 0 0 GO:0048096 8 chromatin-mediated maintenance of transcription 6 6 1 1 0 1 0 0 96 6 2445 0.79394 1.0 1.0 0.0 0 0 0 0 0 GO:0048168 6 regulation of neuronal synaptic plasticity 24 25 1 1 0 1 0 0 96 25 2426 0.38093 1.0 1.0 0.0 0 0 0 0 0 GO:0048255 7 mRNA stabilization 10 10 1 0 1 1 0 0 96 10 2441 0.68052 1.0 1.0 0.0 0 0 0 0 0 GO:0048562 5 embryonic organ morphogenesis 19 20 1 1 0 1 0 0 96 20 2431 0.46239 1.0 1.0 0.0 0 0 0 0 0 GO:0048565 5 digestive tract development 26 28 1 1 0 1 0 0 96 28 2423 0.33905 1.0 0.62403 0.0 0 0 0 0 0 GO:0048592 6 eye morphogenesis 16 16 1 1 0 1 0 0 96 16 2435 0.53979 1.0 1.0 0.0 0 0 0 0 0 GO:0048598 4 embryonic morphogenesis 73 77 1 1 0 1 0 0 96 77 2374 0.049574 1.0 0.11714 0.0 0 0 0 0 0 GO:0048733 6 sebaceous gland development 2 3 1 1 0 1 0 0 96 3 2448 0.89109 1.0 1.0 0.0 0 0 0 0 0 GO:0048812 8 neuron projection morphogenesis 51 55 1 1 0 1 0 0 96 55 2396 0.11809 1.0 0.26901 0.0 0 0 0 0 0 GO:0048858 6 cell projection morphogenesis 52 56 1 1 0 1 0 0 96 56 2395 0.11354 1.0 0.27165 0.0 0 0 0 0 0 GO:0050711 7 negative regulation of interleukin-1 secretion 3 3 1 1 0 1 0 0 96 3 2448 0.89109 1.0 1.0 0.0 0 0 0 0 0 GO:0050713 8 negative regulation of interleukin-1 beta secretion 2 2 1 1 0 1 0 0 96 2 2449 0.92602 1.0 1.0 0.0 0 0 0 0 0 GO:0050732 10 negative regulation of peptidyl-tyrosine phosphorylation 24 24 1 1 0 1 0 0 96 24 2427 0.396 1.0 1.0 0.0 0 0 0 0 0 GO:0050891 4 multicellular organismal water homeostasis 11 11 1 1 0 1 0 0 96 11 2440 0.65477 1.0 1.0 0.0 0 0 0 0 0 GO:0050919 5 negative chemotaxis 5 5 1 1 0 1 0 0 96 5 2446 0.8251 1.0 1.0 0.0 0 0 0 0 0 GO:0050992 6 dimethylallyl diphosphate biosynthetic process 1 1 1 0 1 1 0 0 96 1 2450 0.96231 1.0 1.0 0.0 0 0 0 0 0 GO:0050993 6 dimethylallyl diphosphate metabolic process 1 1 1 0 1 1 0 0 96 1 2450 0.96231 1.0 1.0 0.0 0 0 0 0 0 GO:0051006 8 positive regulation of lipoprotein lipase activity 5 5 1 1 0 1 0 0 96 5 2446 0.8251 1.0 1.0 0.0 0 0 0 0 0 GO:0051055 7 negative regulation of lipid biosynthetic process 19 19 1 1 0 1 0 0 96 19 2432 0.48065 1.0 1.0 0.0 0 0 0 0 0 GO:0051056 7 regulation of small GTPase mediated signal transduction 38 40 1 1 0 1 0 0 96 40 2411 0.21248 1.0 0.40203 0.0 0 0 0 0 0 GO:0051057 8 positive regulation of small GTPase mediated signal transduction 17 18 1 1 0 1 0 0 96 18 2433 0.49961 1.0 1.0 0.0 0 0 0 0 0 GO:0051169 5 nuclear transport 37 41 1 1 0 1 0 0 96 41 2410 0.20434 1.0 0.40364 0.0 0 0 0 0 0 GO:0051170 7 import into nucleus 23 24 1 1 0 1 0 0 96 24 2427 0.396 1.0 1.0 0.0 0 0 0 0 0 GO:0051180 5 vitamin transport 12 14 1 1 0 1 0 0 96 14 2437 0.58316 1.0 1.0 0.0 0 0 0 0 0 GO:0051260 8 protein homooligomerization 31 35 1 1 0 1 0 0 96 35 2416 0.25822 1.0 0.64103 0.0 0 0 0 0 0 GO:0051385 7 response to mineralocorticoid 32 37 2 2 0 2 0 0 96 37 2414 0.23886 1.0 0.40003 0.0 0 0 0 0 0 GO:0051412 6 response to corticosterone 23 27 2 2 0 2 0 0 96 27 2424 0.35247 1.0 0.62325 0.0 0 0 0 0 0 GO:0051492 7 regulation of stress fiber assembly 24 27 1 1 0 1 0 0 96 27 2424 0.35247 1.0 0.62325 0.0 0 0 0 0 0 GO:0051495 8 positive regulation of cytoskeleton organization 51 55 1 1 0 1 0 0 96 55 2396 0.11809 1.0 0.26901 0.0 0 0 0 0 0 GO:0051496 8 positive regulation of stress fiber assembly 18 21 1 1 0 1 0 0 96 21 2430 0.44483 1.0 1.0 0.0 0 0 0 0 0 GO:0051764 7 actin crosslink formation 4 4 1 1 0 0 0 0 96 4 2447 0.85747 1.0 1.0 0.0 0 0 0 0 0 GO:0051781 6 positive regulation of cell division 23 24 1 1 0 1 0 0 96 24 2427 0.396 1.0 1.0 0.0 0 0 0 0 0 GO:0051988 6 regulation of attachment of spindle microtubules to kinetochore 6 7 1 1 0 1 0 0 96 7 2444 0.76394 1.0 1.0 0.0 0 0 0 0 0 GO:0052803 5 imidazole-containing compound metabolic process 2 2 1 1 0 1 0 0 96 2 2449 0.92602 1.0 1.0 0.0 0 0 0 0 0 GO:0052805 6 imidazole-containing compound catabolic process 2 2 1 1 0 1 0 0 96 2 2449 0.92602 1.0 1.0 0.0 0 0 0 0 0 GO:0060193 7 positive regulation of lipase activity 18 18 1 1 0 1 0 0 96 18 2433 0.49961 1.0 1.0 0.0 0 0 0 0 0 GO:0060353 5 regulation of cell adhesion molecule production 7 7 1 1 0 1 0 0 96 7 2444 0.76394 1.0 1.0 0.0 0 0 0 0 0 GO:0060354 6 negative regulation of cell adhesion molecule production 3 3 1 1 0 1 0 0 96 3 2448 0.89109 1.0 1.0 0.0 0 0 0 0 0 GO:0060562 5 epithelial tube morphogenesis 21 22 1 1 0 0 0 0 96 22 2429 0.42792 1.0 1.0 0.0 0 0 0 0 0 GO:0060574 7 intestinal epithelial cell maturation 3 4 1 1 0 1 0 0 96 4 2447 0.85747 1.0 1.0 0.0 0 0 0 0 0 GO:0061013 7 regulation of mRNA catabolic process 16 17 1 0 1 1 0 0 96 17 2434 0.51932 1.0 1.0 0.0 0 0 0 0 0 GO:0061045 7 negative regulation of wound healing 33 35 1 1 0 1 0 0 96 35 2416 0.25822 1.0 0.64103 0.0 0 0 0 0 0 GO:0061073 4 ciliary body morphogenesis 2 2 1 1 0 1 0 0 96 2 2449 0.92602 1.0 1.0 0.0 0 0 0 0 0 GO:0061097 8 regulation of protein tyrosine kinase activity 24 26 1 1 0 1 0 0 96 26 2425 0.36643 1.0 0.623 0.0 0 0 0 0 0 GO:0061099 9 negative regulation of protein tyrosine kinase activity 12 12 1 1 0 1 0 0 96 12 2439 0.62999 1.0 1.0 0.0 0 0 0 0 0 GO:0061154 6 endothelial tube morphogenesis 6 7 1 1 0 0 0 0 96 7 2444 0.76394 1.0 1.0 0.0 0 0 0 0 0 GO:0061365 8 positive regulation of triglyceride lipase activity 5 5 1 1 0 1 0 0 96 5 2446 0.8251 1.0 1.0 0.0 0 0 0 0 0 GO:0062014 6 negative regulation of small molecule metabolic process 34 38 1 1 0 1 0 0 96 38 2413 0.22972 1.0 0.40021 0.0 0 0 0 0 0 GO:0070059 7 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress 15 15 1 1 0 1 0 0 96 15 2436 0.56106 1.0 1.0 0.0 0 0 0 0 0 GO:0070167 5 regulation of biomineral tissue development 22 25 1 1 0 1 0 0 96 25 2426 0.38093 1.0 1.0 0.0 0 0 0 0 0 GO:0070168 6 negative regulation of biomineral tissue development 7 9 1 1 0 1 0 0 96 9 2442 0.70728 1.0 1.0 0.0 0 0 0 0 0 GO:0070371 9 ERK1 and ERK2 cascade 13 14 1 1 0 1 0 0 96 14 2437 0.58316 1.0 1.0 0.0 0 0 0 0 0 GO:0070508 9 cholesterol import 4 4 1 1 0 1 0 0 96 4 2447 0.85747 1.0 1.0 0.0 0 0 0 0 0 GO:0070587 7 regulation of cell-cell adhesion involved in gastrulation 4 4 1 1 0 1 0 0 96 4 2447 0.85747 1.0 1.0 0.0 0 0 0 0 0 GO:0070723 6 response to cholesterol 17 17 1 1 0 1 0 0 96 17 2434 0.51932 1.0 1.0 0.0 0 0 0 0 0 GO:0070830 9 bicellular tight junction assembly 9 9 1 1 0 1 0 0 96 9 2442 0.70728 1.0 1.0 0.0 0 0 0 0 0 GO:0070857 7 regulation of bile acid biosynthetic process 4 5 1 1 0 1 0 0 96 5 2446 0.8251 1.0 1.0 0.0 0 0 0 0 0 GO:0071156 7 regulation of cell cycle arrest 20 21 1 1 0 1 0 0 96 21 2430 0.44483 1.0 1.0 0.0 0 0 0 0 0 GO:0071158 8 positive regulation of cell cycle arrest 13 13 1 1 0 1 0 0 96 13 2438 0.60613 1.0 1.0 0.0 0 0 0 0 0 GO:0071214 4 cellular response to abiotic stimulus 122 125 2 2 0 2 0 0 96 125 2326 0.0072569 1.0 0.013638 0.0 0 0 0 0 0 GO:0071276 7 cellular response to cadmium ion 18 20 1 1 0 1 0 0 96 20 2431 0.46239 1.0 1.0 0.0 0 0 0 0 0 GO:0071277 7 cellular response to calcium ion 24 25 2 2 0 2 0 0 96 25 2426 0.38093 1.0 1.0 0.0 0 0 0 0 0 GO:0071322 6 cellular response to carbohydrate stimulus 59 62 1 1 0 1 0 0 96 62 2389 0.089671 1.0 0.17145 0.0 0 0 0 0 0 GO:0071326 7 cellular response to monosaccharide stimulus 53 56 1 1 0 1 0 0 96 56 2395 0.11354 1.0 0.27165 0.0 0 0 0 0 0 GO:0071331 8 cellular response to hexose stimulus 52 55 1 1 0 1 0 0 96 55 2396 0.11809 1.0 0.26901 0.0 0 0 0 0 0 GO:0071333 8 cellular response to glucose stimulus 51 54 1 1 0 1 0 0 96 54 2397 0.12282 1.0 0.26668 0.0 0 0 0 0 0 GO:0071377 7 cellular response to glucagon stimulus 7 7 1 1 0 1 0 0 96 7 2444 0.76394 1.0 1.0 0.0 0 0 0 0 0 GO:0071397 7 cellular response to cholesterol 8 8 1 1 0 1 0 0 96 8 2443 0.73507 1.0 1.0 0.0 0 0 0 0 0 GO:0071478 5 cellular response to radiation 59 61 2 2 0 2 0 0 96 61 2390 0.093272 1.0 0.17067 0.0 0 0 0 0 0 GO:0071479 6 cellular response to ionizing radiation 24 24 2 2 0 2 0 0 96 24 2427 0.396 1.0 1.0 0.0 0 0 0 0 0 GO:0071480 7 cellular response to gamma radiation 15 15 1 1 0 1 0 0 96 15 2436 0.56106 1.0 1.0 0.0 0 0 0 0 0 GO:0071482 6 cellular response to light stimulus 37 39 1 1 0 1 0 0 96 39 2412 0.22093 1.0 0.40088 0.0 0 0 0 0 0 GO:0071493 8 cellular response to UV-B 3 4 1 1 0 1 0 0 96 4 2447 0.85747 1.0 1.0 0.0 0 0 0 0 0 GO:0071850 7 mitotic cell cycle arrest 4 4 1 1 0 1 0 0 96 4 2447 0.85747 1.0 1.0 0.0 0 0 0 0 0 GO:0072331 6 signal transduction by p53 class mediator 28 29 1 1 0 1 0 0 96 29 2422 0.32613 1.0 0.62529 0.0 0 0 0 0 0 GO:0072332 7 intrinsic apoptotic signaling pathway by p53 class mediator 19 19 1 1 0 1 0 0 96 19 2432 0.48065 1.0 1.0 0.0 0 0 0 0 0 GO:0072395 6 signal transduction involved in cell cycle checkpoint 10 10 1 1 0 1 0 0 96 10 2441 0.68052 1.0 1.0 0.0 0 0 0 0 0 GO:0072401 7 signal transduction involved in DNA integrity checkpoint 10 10 1 1 0 1 0 0 96 10 2441 0.68052 1.0 1.0 0.0 0 0 0 0 0 GO:0072413 7 signal transduction involved in mitotic cell cycle checkpoint 6 6 1 1 0 1 0 0 96 6 2445 0.79394 1.0 1.0 0.0 0 0 0 0 0 GO:0072422 7 signal transduction involved in DNA damage checkpoint 10 10 1 1 0 1 0 0 96 10 2441 0.68052 1.0 1.0 0.0 0 0 0 0 0 GO:0072431 9 signal transduction involved in mitotic G1 DNA damage checkpoint 5 5 1 1 0 1 0 0 96 5 2446 0.8251 1.0 1.0 0.0 0 0 0 0 0 GO:0072577 7 endothelial cell apoptotic process 1 2 1 1 0 1 0 0 96 2 2449 0.92602 1.0 1.0 0.0 0 0 0 0 0 GO:0090080 8 positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway 1 1 1 1 0 1 0 0 96 1 2450 0.96231 1.0 1.0 0.0 0 0 0 0 0 GO:0090305 6 nucleic acid phosphodiester bond hydrolysis 28 32 1 0 1 1 0 0 96 32 2419 0.29021 1.0 0.6316 0.0 0 0 0 0 0 GO:0090316 7 positive regulation of intracellular protein transport 45 48 1 1 0 1 0 0 96 48 2403 0.1554 1.0 0.25996 0.0 0 0 0 0 0 GO:0090398 5 cellular senescence 15 15 1 1 0 1 0 0 96 15 2436 0.56106 1.0 1.0 0.0 0 0 0 0 0 GO:0090399 5 replicative senescence 5 5 1 1 0 1 0 0 96 5 2446 0.8251 1.0 1.0 0.0 0 0 0 0 0 GO:0090501 7 RNA phosphodiester bond hydrolysis 18 22 1 0 1 1 0 0 96 22 2429 0.42792 1.0 1.0 0.0 0 0 0 0 0 GO:0090503 8 RNA phosphodiester bond hydrolysis, exonucleolytic 7 7 1 0 1 1 0 0 96 7 2444 0.76394 1.0 1.0 0.0 0 0 0 0 0 GO:0090596 5 sensory organ morphogenesis 17 17 1 1 0 1 0 0 96 17 2434 0.51932 1.0 1.0 0.0 0 0 0 0 0 GO:0090630 8 activation of GTPase activity 11 13 1 1 0 1 0 0 96 13 2438 0.60613 1.0 1.0 0.0 0 0 0 0 0 GO:0097193 6 intrinsic apoptotic signaling pathway 66 67 2 2 0 2 0 0 96 67 2384 0.073626 1.0 0.17925 0.0 0 0 0 0 0 GO:0097421 6 liver regeneration 31 34 1 1 0 0 0 0 96 34 2417 0.26848 1.0 0.63759 0.0 0 0 0 0 0 GO:0099170 7 postsynaptic modulation of chemical synaptic transmission 6 6 1 1 0 0 0 0 96 6 2445 0.79394 1.0 1.0 0.0 0 0 0 0 0 GO:0104004 4 cellular response to environmental stimulus 122 125 2 2 0 2 0 0 96 125 2326 0.0072569 1.0 0.013638 0.0 0 0 0 0 0 GO:0110020 7 regulation of actomyosin structure organization 31 34 2 2 0 2 0 0 96 34 2417 0.26848 1.0 0.63759 0.0 0 0 0 0 0 GO:0110149 4 regulation of biomineralization 22 25 1 1 0 1 0 0 96 25 2426 0.38093 1.0 1.0 0.0 0 0 0 0 0 GO:0110150 5 negative regulation of biomineralization 7 9 1 1 0 1 0 0 96 9 2442 0.70728 1.0 1.0 0.0 0 0 0 0 0 GO:0110154 7 RNA decapping 3 3 1 0 1 1 0 0 96 3 2448 0.89109 1.0 1.0 0.0 0 0 0 0 0 GO:0110156 8 methylguanosine-cap decapping 3 3 1 0 1 1 0 0 96 3 2448 0.89109 1.0 1.0 0.0 0 0 0 0 0 GO:0120039 7 plasma membrane bounded cell projection morphogenesis 51 55 1 1 0 1 0 0 96 55 2396 0.11809 1.0 0.26901 0.0 0 0 0 0 0 GO:0120163 5 negative regulation of cold-induced thermogenesis 12 14 1 1 0 1 0 0 96 14 2437 0.58316 1.0 1.0 0.0 0 0 0 0 0 GO:0120188 7 regulation of bile acid secretion 7 8 1 1 0 1 0 0 96 8 2443 0.73507 1.0 1.0 0.0 0 0 0 0 0 GO:0120192 8 tight junction assembly 10 10 1 1 0 1 0 0 96 10 2441 0.68052 1.0 1.0 0.0 0 0 0 0 0 GO:0120193 7 tight junction organization 10 10 1 1 0 1 0 0 96 10 2441 0.68052 1.0 1.0 0.0 0 0 0 0 0 GO:1900024 7 regulation of substrate adhesion-dependent cell spreading 16 18 1 1 0 1 0 0 96 18 2433 0.49961 1.0 1.0 0.0 0 0 0 0 0 GO:1900026 8 positive regulation of substrate adhesion-dependent cell spreading 12 14 1 1 0 1 0 0 96 14 2437 0.58316 1.0 1.0 0.0 0 0 0 0 0 GO:1900180 7 regulation of protein localization to nucleus 47 51 1 1 0 1 0 0 96 51 2400 0.13817 1.0 0.2617 0.0 0 0 0 0 0 GO:1900182 7 positive regulation of protein localization to nucleus 32 34 1 1 0 1 0 0 96 34 2417 0.26848 1.0 0.63759 0.0 0 0 0 0 0 GO:1901216 7 positive regulation of neuron death 58 61 1 1 0 1 0 0 96 61 2390 0.093272 1.0 0.17067 0.0 0 0 0 0 0 GO:1901987 7 regulation of cell cycle phase transition 80 85 1 1 0 1 0 0 96 85 2366 0.036085 1.0 0.074904 0.0 0 0 0 0 0 GO:1901988 8 negative regulation of cell cycle phase transition 40 41 1 1 0 1 0 0 96 41 2410 0.20434 1.0 0.40364 0.0 0 0 0 0 0 GO:1901990 7 regulation of mitotic cell cycle phase transition 75 79 1 1 0 1 0 0 96 79 2372 0.045795 1.0 0.073158 0.0 0 0 0 0 0 GO:1901991 8 negative regulation of mitotic cell cycle phase transition 37 38 1 1 0 1 0 0 96 38 2413 0.22972 1.0 0.40021 0.0 0 0 0 0 0 GO:1902369 8 negative regulation of RNA catabolic process 11 11 1 0 1 1 0 0 96 11 2440 0.65477 1.0 1.0 0.0 0 0 0 0 0 GO:1902373 8 negative regulation of mRNA catabolic process 11 11 1 0 1 1 0 0 96 11 2440 0.65477 1.0 1.0 0.0 0 0 0 0 0 GO:1902400 8 intracellular signal transduction involved in G1 DNA damage checkpoint 5 5 1 1 0 1 0 0 96 5 2446 0.8251 1.0 1.0 0.0 0 0 0 0 0 GO:1902402 8 signal transduction involved in mitotic DNA damage checkpoint 6 6 1 1 0 1 0 0 96 6 2445 0.79394 1.0 1.0 0.0 0 0 0 0 0 GO:1902403 8 signal transduction involved in mitotic DNA integrity checkpoint 6 6 1 1 0 1 0 0 96 6 2445 0.79394 1.0 1.0 0.0 0 0 0 0 0 GO:1902749 8 regulation of cell cycle G2/M phase transition 30 32 1 1 0 1 0 0 96 32 2419 0.29021 1.0 0.6316 0.0 0 0 0 0 0 GO:1902750 9 negative regulation of cell cycle G2/M phase transition 15 16 1 1 0 1 0 0 96 16 2435 0.53979 1.0 1.0 0.0 0 0 0 0 0 GO:1902806 8 regulation of cell cycle G1/S phase transition 42 44 1 1 0 1 0 0 96 44 2407 0.18174 1.0 0.41092 0.0 0 0 0 0 0 GO:1902807 9 negative regulation of cell cycle G1/S phase transition 19 19 1 1 0 1 0 0 96 19 2432 0.48065 1.0 1.0 0.0 0 0 0 0 0 GO:1902905 7 positive regulation of supramolecular fiber organization 50 53 1 1 0 1 0 0 96 53 2398 0.12774 1.0 0.26468 0.0 0 0 0 0 0 GO:1902994 8 regulation of phospholipid efflux 2 2 1 1 0 1 0 0 96 2 2449 0.92602 1.0 1.0 0.0 0 0 0 0 0 GO:1902995 8 positive regulation of phospholipid efflux 2 2 1 1 0 1 0 0 96 2 2449 0.92602 1.0 1.0 0.0 0 0 0 0 0 GO:1903035 6 negative regulation of response to wounding 34 36 1 1 0 1 0 0 96 36 2415 0.24835 1.0 0.64474 0.0 0 0 0 0 0 GO:1903311 7 regulation of mRNA metabolic process 28 31 1 0 1 1 0 0 96 31 2420 0.30173 1.0 0.6291 0.0 0 0 0 0 0 GO:1903312 8 negative regulation of mRNA metabolic process 13 14 1 0 1 1 0 0 96 14 2437 0.58316 1.0 1.0 0.0 0 0 0 0 0 GO:1903699 7 tarsal gland development 1 1 1 1 0 1 0 0 96 1 2450 0.96231 1.0 1.0 0.0 0 0 0 0 0 GO:1903793 7 positive regulation of anion transport 25 26 1 1 0 1 0 0 96 26 2425 0.36643 1.0 0.623 0.0 0 0 0 0 0 GO:1903829 6 positive regulation of cellular protein localization 83 90 1 1 0 1 0 0 96 90 2361 0.029573 1.0 0.04799 0.0 0 0 0 0 0 GO:1903964 8 monounsaturated fatty acid metabolic process 2 2 1 1 0 1 0 0 96 2 2449 0.92602 1.0 1.0 0.0 0 0 0 0 0 GO:1903966 8 monounsaturated fatty acid biosynthetic process 2 2 1 1 0 1 0 0 96 2 2449 0.92602 1.0 1.0 0.0 0 0 0 0 0 GO:1904030 8 negative regulation of cyclin-dependent protein kinase activity 8 8 1 1 0 1 0 0 96 8 2443 0.73507 1.0 1.0 0.0 0 0 0 0 0 GO:1904031 8 positive regulation of cyclin-dependent protein kinase activity 18 18 1 1 0 1 0 0 96 18 2433 0.49961 1.0 1.0 0.0 0 0 0 0 0 GO:1904035 8 regulation of epithelial cell apoptotic process 41 44 1 1 0 1 0 0 96 44 2407 0.18174 1.0 0.41092 0.0 0 0 0 0 0 GO:1904036 9 negative regulation of epithelial cell apoptotic process 26 27 1 1 0 1 0 0 96 27 2424 0.35247 1.0 0.62325 0.0 0 0 0 0 0 GO:1904251 6 regulation of bile acid metabolic process 5 6 1 1 0 1 0 0 96 6 2445 0.79394 1.0 1.0 0.0 0 0 0 0 0 GO:1904589 8 regulation of protein import 32 35 1 1 0 1 0 0 96 35 2416 0.25822 1.0 0.64103 0.0 0 0 0 0 0 GO:1904591 7 positive regulation of protein import 23 24 1 1 0 1 0 0 96 24 2427 0.396 1.0 1.0 0.0 0 0 0 0 0 GO:1904640 6 response to methionine 3 3 1 1 0 1 0 0 96 3 2448 0.89109 1.0 1.0 0.0 0 0 0 0 0 GO:1905178 6 regulation of cardiac muscle tissue regeneration 2 2 1 1 0 1 0 0 96 2 2449 0.92602 1.0 1.0 0.0 0 0 0 0 0 GO:1905179 7 negative regulation of cardiac muscle tissue regeneration 2 2 1 1 0 1 0 0 96 2 2449 0.92602 1.0 1.0 0.0 0 0 0 0 0 GO:1990928 5 response to amino acid starvation 14 16 1 1 0 1 0 0 96 16 2435 0.53979 1.0 1.0 0.0 0 0 0 0 0 GO:2000045 8 regulation of G1/S transition of mitotic cell cycle 38 40 1 1 0 1 0 0 96 40 2411 0.21248 1.0 0.40203 0.0 0 0 0 0 0 GO:2000134 9 negative regulation of G1/S transition of mitotic cell cycle 18 18 1 1 0 1 0 0 96 18 2433 0.49961 1.0 1.0 0.0 0 0 0 0 0 GO:2000351 9 regulation of endothelial cell apoptotic process 25 28 1 1 0 1 0 0 96 28 2423 0.33905 1.0 0.62403 0.0 0 0 0 0 0 GO:2000352 10 negative regulation of endothelial cell apoptotic process 17 18 1 1 0 1 0 0 96 18 2433 0.49961 1.0 1.0 0.0 0 0 0 0 0 GO:2000379 7 positive regulation of reactive oxygen species metabolic process 59 62 1 1 0 1 0 0 96 62 2389 0.089671 1.0 0.17145 0.0 0 0 0 0 0 GO:2000431 6 regulation of cytokinesis, actomyosin contractile ring assembly 1 1 1 1 0 1 0 0 96 1 2450 0.96231 1.0 1.0 0.0 0 0 0 0 0 GO:2001138 7 regulation of phospholipid transport 4 4 1 1 0 1 0 0 96 4 2447 0.85747 1.0 1.0 0.0 0 0 0 0 0 GO:2001140 7 positive regulation of phospholipid transport 4 4 1 1 0 1 0 0 96 4 2447 0.85747 1.0 1.0 0.0 0 0 0 0 0 GO:0002697 5 regulation of immune effector process 103 117 5 5 4 5 4 4 92 113 2338 0.54609 0.65269 1.0 3.42 309607;63868;25599;25649 rt1-ce5;hspd1;cd74;apoa2 RT1-CE5_32445;HSPD1_8849;CD74_8252;APOA2_33095 46.931920000000005 44.63305 3.54778 38.30833838053537 51.026499694151525 39.91070580065719 28.402785 26.64045 1.51564 23.480586004006938 30.842842477139186 24.630336609801077 80.9101375 83.62935 8.55785 63.76325745818637 84.84696829643178 62.744545159564886 54.8206;34.4455;94.9138;3.54778 26.5902;26.6907;58.8146;1.51564 147.824;48.4857;118.773;8.55785 3 1 3 63868;25599;25649 HSPD1_8849;CD74_8252;APOA2_33095 44.30236 34.4455 46.47370944367148 29.00698 26.6907 28.71961993218573 58.60551666666667 48.4857 55.80011504832076 34.4455;94.9138;3.54778 26.6907;58.8146;1.51564 48.4857;118.773;8.55785 1 309607 RT1-CE5_32445 54.8206 54.8206 26.5902 26.5902 147.824 147.824 54.8206 26.5902 147.824 0 Exp 2,2(0.5);Hill,1(0.25);Poly 2,1(0.25) 1.7200983472724258 6.887296915054321 1.6557694673538208 1.8475407361984253 0.08999074575073222 1.6919933557510376 9.389748387075329 84.47409161292467 5.3918107160731985 51.41375928392681 18.422145190977375 143.39812980902263 UP 0.75 0.25 0.0 GO:0010949 8 negative regulation of intestinal phytosterol absorption 2 2 1 1 1 1 1 1 95 1 2450 0.99859 0.073976 0.073976 50.0 114628 abcg5 ABCG5_7947 33.1119 33.1119 33.1119 33.1119 24.2098 24.2098 24.2098 24.209800000000005 50.4329 50.4329 50.4329 50.4329 0.0 33.1119 0.0 33.1119 33.1119 24.2098 50.4329 0 1 0 1 114628 ABCG5_7947 33.1119 33.1119 24.2098 24.2098 50.4329 50.4329 33.1119 24.2098 50.4329 0 Exp 2,1(1) 2.5319817066192627 2.5319817066192627 2.5319817066192627 2.5319817066192627 0.0 2.5319817066192627 33.1119 33.1119 24.2098 24.2098 50.4329 50.4329 DOWN 0.0 1.0 0.0 GO:0045796 8 negative regulation of intestinal cholesterol absorption 2 2 1 1 1 1 1 1 95 1 2450 0.99859 0.073976 0.073976 50.0 114628 abcg5 ABCG5_7947 33.1119 33.1119 33.1119 33.1119 24.2098 24.2098 24.2098 24.209800000000005 50.4329 50.4329 50.4329 50.4329 0.0 33.1119 0.0 33.1119 33.1119 24.2098 50.4329 0 1 0 1 114628 ABCG5_7947 33.1119 33.1119 24.2098 24.2098 50.4329 50.4329 33.1119 24.2098 50.4329 0 Exp 2,1(1) 2.5319817066192627 2.5319817066192627 2.5319817066192627 2.5319817066192627 0.0 2.5319817066192627 33.1119 33.1119 24.2098 24.2098 50.4329 50.4329 DOWN 0.0 1.0 0.0 GO:0033554 4 cellular response to stress 394 417 19 19 13 19 13 13 83 404 2047 0.27261 0.81588 0.57316 3.12 360243;78968;24950;25664;338475;291234;316273;293502;63868;24471;114494;25612;170465 top2a;srebf1;srd5a1;pparg;nrep;mki67;mcm3;kif22;hspd1;hspb1;ccna2;asns;acaa2 TOP2A_10059;SREBF1_32750;SRD5A1_32503;PPARG_32510;NREP_9364;MKI67_9232;MCM3_9207;KIF22_8963;HSPD1_8849;HSPB1_8847;CCNA2_8221;ASNS_8091;ACAA2_7955 25664(0.0441) 51.39726923076924 52.8265 28.1893 16.27827447783212 53.631536789752666 15.669852504384526 33.733938461538465 33.259 18.8326 9.175170041161666 35.11120394157585 8.749578237146665 97.95711538461539 90.0448 35.9474 54.38131497464372 101.03870197784708 50.19469209207403 54.9577;41.2009;29.2087;60.1903;69.4104;49.7822;54.0045;73.9175;34.4455;41.6322;52.8265;28.1893;78.3988 18.8326;31.4864;22.9308;43.9036;43.1468;35.6665;33.259;47.5608;26.6907;30.9494;37.3288;23.1774;43.6084 218.525;60.0774;39.9852;101.057;157.944;82.1147;111.753;165.416;48.4857;63.3196;90.0448;35.9474;98.7727 5 8 5 78968;25664;63868;24471;25612 SREBF1_32750;PPARG_32510;HSPD1_8849;HSPB1_8847;ASNS_8091 41.13164 41.2009 11.996838240053064 31.241499999999995 30.9494 7.845596922478258 61.77741999999999 60.0774 24.454107762746133 41.2009;60.1903;34.4455;41.6322;28.1893 31.4864;43.9036;26.6907;30.9494;23.1774 60.0774;101.057;48.4857;63.3196;35.9474 8 360243;24950;338475;291234;316273;293502;114494;170465 TOP2A_10059;SRD5A1_32503;NREP_9364;MKI67_9232;MCM3_9207;KIF22_8963;CCNA2_8221;ACAA2_7955 57.8132875 54.4811 15.80168204296504 35.2917125 36.49765 10.096087304840633 120.56942499999998 105.26285 56.6449232560859 54.9577;29.2087;69.4104;49.7822;54.0045;73.9175;52.8265;78.3988 18.8326;22.9308;43.1468;35.6665;33.259;47.5608;37.3288;43.6084 218.525;39.9852;157.944;82.1147;111.753;165.416;90.0448;98.7727 0 Exp 2,7(0.54);Linear,5(0.39);Poly 2,1(0.08) 1.975622911084327 26.190986156463623 1.5239794254302979 3.2609751224517822 0.44978524506276557 1.912555456161499 42.54829842464884 60.246240036889624 28.746259211750882 38.72161771132605 68.39509581894295 127.51913495028784 DOWN 0.38461538461538464 0.6153846153846154 0.0 GO:0042220 5 response to cocaine 23 24 2 2 2 2 2 2 94 22 2429 0.94078 0.22823 0.22823 8.33 63868;114494 hspd1;ccna2 HSPD1_8849;CCNA2_8221 43.636 43.636 34.4455 12.997329744989926 42.005220810550014 12.791078882194167 32.00975 32.00975 26.6907 7.522272648940654 31.065928004717485 7.402903882088605 69.26525 69.26525 48.4857 29.38672143000986 65.57808850648654 28.920392055546245 0.5 43.636 34.4455;52.8265 26.6907;37.3288 48.4857;90.0448 1 1 1 63868 HSPD1_8849 34.4455 34.4455 26.6907 26.6907 48.4857 48.4857 34.4455 26.6907 48.4857 1 114494 CCNA2_8221 52.8265 52.8265 37.3288 37.3288 90.0448 90.0448 52.8265 37.3288 90.0448 0 Exp 2,1(0.5);Linear,1(0.5) 1.9623083764255351 3.9813674688339233 1.6557694673538208 2.3255980014801025 0.47364029871293856 1.9906837344169617 25.622620000000005 61.64938 21.584411999999993 42.435088 28.537332000000006 109.99316799999998 CONFLICT 0.5 0.5 0.0 GO:0097305 5 response to alcohol 168 183 10 10 6 9 5 5 91 178 2273 0.29992 0.83283 0.54913 2.73 286954;78968;25664;25086;65155 ugt2b1;srebf1;pparg;cyp2e1;alas1 UGT2B10_33303,UGT2B1_33224;SREBF1_32750;PPARG_32510;CYP2E1_8421;ALAS1_8018 25664(0.0441) 29.802278 27.1843 7.89174 21.436702934999584 34.52447145549281 21.846822056756274 21.685543 21.5215 4.16797 16.599316572126398 25.275982515054128 16.780844951782697 47.81993 36.6615 15.8079 34.02967956658569 55.32225349599076 35.22992703844963 12.54415;41.2009;60.1903;7.89174;27.1843 7.348245;31.4864;43.9036;4.16797;21.5215 25.495849999999997;60.0774;101.057;15.8079;36.6615 6 0 5 286954;78968;25664;25086;65155 UGT2B10_33303,UGT2B1_33224;SREBF1_32750;PPARG_32510;CYP2E1_8421;ALAS1_8018 29.802278 27.1843 21.436702934999584 21.685543 21.5215 16.599316572126398 47.81993 36.6615 34.02967956658569 12.54415;41.2009;60.1903;7.89174;27.1843 7.348245;31.4864;43.9036;4.16797;21.5215 25.495849999999997;60.0774;101.057;15.8079;36.6615 0 0 Exp 2,2(0.34);Exp 4,2(0.34);Linear,1(0.17);Poly 2,1(0.17) 1.6890225957663667 10.171926140785217 1.5239794254302979 1.912555456161499 0.16066163316300638 1.6825589537620544 11.012179409357689 48.5923765906423 7.135600507757145 36.23548549224285 17.991600708738897 77.6482592912611 UP 1.0 0.0 0.0 GO:0009064 8 glutamine family amino acid metabolic process 23 24 2 2 2 2 2 2 94 22 2429 0.94078 0.22823 0.22823 8.33 114027;25612 dao;asns DAO_8437;ASNS_8091 17.16145 17.16145 6.1336 15.59573503381614 20.000902523916142 15.069902785812936 12.806785 12.806785 2.43617 14.666264383149853 15.477012554447382 14.171770551747928 26.07505 26.07505 16.2027 13.96161126249403 28.616984205169956 13.490875806936131 0.5 17.16145 6.1336;28.1893 2.43617;23.1774 16.2027;35.9474 2 0 2 114027;25612 DAO_8437;ASNS_8091 17.16145 17.16145 15.59573503381614 12.806785 12.806785 14.666264383149853 26.07505 26.07505 13.96161126249403 6.1336;28.1893 2.43617;23.1774 16.2027;35.9474 0 0 Exp 2,1(0.5);Hill,1(0.5) 2.5935541478000563 5.323708772659302 2.0627336502075195 3.2609751224517822 0.8472846705228704 2.661854386329651 -4.453136000000001 38.776036 -7.5196203999999955 33.1331904 6.7252440000000036 45.424856 UP 1.0 0.0 0.0 GO:0051693 9 actin filament capping 3 3 1 1 1 1 1 1 95 2 2449 0.99588 0.10891 0.10891 33.33 64159 sptan1 SPTAN1_9932 47.5519 47.5519 47.5519 47.5519 34.4152 34.4152 34.4152 34.4152 76.6397 76.6397 76.6397 76.6397 0.0 47.5519 0.0 47.5519 47.5519 34.4152 76.6397 1 0 1 64159 SPTAN1_9932 47.5519 47.5519 34.4152 34.4152 76.6397 76.6397 47.5519 34.4152 76.6397 0 0 Linear,1(1) 1.5062377452850342 1.5062377452850342 1.5062377452850342 1.5062377452850342 0.0 1.5062377452850342 47.5519 47.5519 34.4152 34.4152 76.6397 76.6397 UP 1.0 0.0 0.0 GO:0072348 5 sulfur compound transport 11 12 2 2 2 2 2 2 94 10 2441 0.99109 0.072579 0.072579 16.67 117267;83500 slc26a2;slc22a8 SLC26A2_33072;SLC22A8_9848 53.61785 53.61785 52.4905 1.5943136595414056 53.50110488041763 1.5857418450385592 37.7491 37.7491 37.1479 0.8502251936985963 37.68684145926915 0.8456539648182195 92.23975 92.23975 89.1422 4.380597220128783 91.9189766419813 4.357044974586895 0.0 52.4905 0.5 53.61785 54.7452;52.4905 38.3503;37.1479 95.3373;89.1422 1 1 1 83500 SLC22A8_9848 52.4905 52.4905 37.1479 37.1479 89.1422 89.1422 52.4905 37.1479 89.1422 1 117267 SLC26A2_33072 54.7452 54.7452 38.3503 38.3503 95.3373 95.3373 54.7452 38.3503 95.3373 0 Linear,2(1) 1.586695065778437 3.1759769916534424 1.5239086151123047 1.6520683765411377 0.09062263638157796 1.5879884958267212 51.408243999999996 55.827456 36.570748 38.927451999999995 86.168552 98.310948 CONFLICT 0.5 0.5 0.0 GO:1901617 5 organic hydroxy compound biosynthetic process 60 64 8 7 5 8 4 4 92 60 2391 0.90906 0.21971 0.30258 6.25 296371;25315;114027;25427 pltp;ephx1;dao;cyp51 PLTP_32412;EPHX1_8567;DAO_8437;CYP51_8429 50.581199999999995 54.58279999999999 6.1336 37.336351700721906 58.98069859299053 34.85017699727344 33.3296675 37.12795 2.43617 24.267214821624908 39.427043232284475 21.851375302299452 85.12819999999999 76.46555000000001 16.2027 68.11495541592414 83.04577827449477 51.110768977432556 2.5 81.0889 87.0256;34.0134;6.1336;75.1522 56.6266;26.1579;2.43617;48.098 104.563;48.3681;16.2027;171.379 3 1 3 296371;25315;114027 PLTP_32412;EPHX1_8567;DAO_8437 42.39086666666666 34.0134 41.09154872736404 28.406890000000004 26.1579 27.16512733103417 56.37793333333334 48.3681 44.72140121399745 87.0256;34.0134;6.1336 56.6266;26.1579;2.43617 104.563;48.3681;16.2027 1 25427 CYP51_8429 75.1522 75.1522 48.098 48.098 171.379 171.379 75.1522 48.098 171.379 0 Hill,1(0.25);Linear,2(0.5);Poly 2,1(0.25) 1.7856583981060985 7.20499324798584 1.5084086656570435 2.0627336502075195 0.27191936457337823 1.8169254660606384 13.99157533329253 87.17082466670746 9.54779697480759 57.11153802519241 18.375543692394345 151.88085630760565 UP 0.75 0.25 0.0 GO:0002728 8 negative regulation of natural killer cell cytokine production 1 1 1 1 1 1 1 1 95 0 2451 1.0 0.037691 0.037691 100.0 309607 rt1-ce5 RT1-CE5_32445 54.8206 54.8206 54.8206 54.8206 26.5902 26.5902 26.5902 26.590199999999996 147.824 147.824 147.824 147.824 0.0 54.8206 0.0 54.8206 54.8206 26.5902 147.824 0 1 0 1 309607 RT1-CE5_32445 54.8206 54.8206 26.5902 26.5902 147.824 147.824 54.8206 26.5902 147.824 0 Exp 2,1(1) 1.8475407361984253 1.8475407361984253 1.8475407361984253 1.8475407361984253 0.0 1.8475407361984253 54.8206 54.8206 26.5902 26.5902 147.824 147.824 DOWN 0.0 1.0 0.0 GO:0043322 8 negative regulation of natural killer cell degranulation 1 1 1 1 1 1 1 1 95 0 2451 1.0 0.037691 0.037691 100.0 309607 rt1-ce5 RT1-CE5_32445 54.8206 54.8206 54.8206 54.8206 26.5902 26.5902 26.5902 26.590199999999996 147.824 147.824 147.824 147.824 0.0 54.8206 0.0 54.8206 54.8206 26.5902 147.824 0 1 0 1 309607 RT1-CE5_32445 54.8206 54.8206 26.5902 26.5902 147.824 147.824 54.8206 26.5902 147.824 0 Exp 2,1(1) 1.8475407361984253 1.8475407361984253 1.8475407361984253 1.8475407361984253 0.0 1.8475407361984253 54.8206 54.8206 26.5902 26.5902 147.824 147.824 DOWN 0.0 1.0 0.0 GO:0006635 7 fatty acid beta-oxidation 29 33 11 11 10 11 10 10 86 23 2428 1.0 1.6328E-7 1.6328E-7 30.3 364975;171142;291075;29740;64526;117543;311849;25413;50681;170465 gcdh;ehhadh;eci2;eci1;ech1;decr1;crat;cpt2;acox1;acaa2 GCDH_8693;EHHADH_8534;ECI2_8521;ECI1_8520;ECH1_8516;DECR1_8458;CRAT_8375;CPT2_8374;ACOX1_7973;ACAA2_7955 21.759351 13.8337 7.29984 21.39355623406598 23.842188735783974 24.218429506198984 14.280731 9.41634 1.97988 12.606735881887772 15.105797565980094 13.916512924279015 33.08412 29.68235 11.8779 24.7242502112939 35.91259905193653 27.82165843930871 0.5 8.014479999999999 2.5 9.429775 15.9021;7.29984;8.72912;11.7653;9.87438;21.6199;8.98517;31.2175;23.8014;78.3988 10.4227;5.26587;5.10151;8.40998;6.59127;17.4928;1.97988;24.8356;19.0993;43.6084 31.2818;11.8779;17.7951;18.8402;19.44;28.0829;31.3726;42.0237;31.3543;98.7727 9 1 9 364975;171142;291075;29740;64526;117543;311849;25413;50681 GCDH_8693;EHHADH_8534;ECI2_8521;ECI1_8520;ECH1_8516;DECR1_8458;CRAT_8375;CPT2_8374;ACOX1_7973 15.466078888888887 11.7653 8.326791002971145 11.02210111111111 8.40998 7.7029857734897895 25.78538888888889 28.0829 9.401888850710323 15.9021;7.29984;8.72912;11.7653;9.87438;21.6199;8.98517;31.2175;23.8014 10.4227;5.26587;5.10151;8.40998;6.59127;17.4928;1.97988;24.8356;19.0993 31.2818;11.8779;17.7951;18.8402;19.44;28.0829;31.3726;42.0237;31.3543 1 170465 ACAA2_7955 78.3988 78.3988 43.6084 43.6084 98.7727 98.7727 78.3988 43.6084 98.7727 0 Exp 2,1(0.1);Hill,4(0.4);Linear,2(0.2);Poly 2,3(0.3) 2.136387860132493 22.924050092697144 1.5464483499526978 3.9502921104431152 0.9700020399838425 1.7989360690116882 8.499487469693612 35.019214530306385 6.466995147600384 22.094466852399613 17.759870954912742 48.408369045087255 UP 0.9 0.1 0.0 GO:0019538 4 protein metabolic process 588 639 14 14 11 13 11 11 85 628 1823 6.1583E-4 0.99978 0.001085 1.72 365813;25664;362094;315994;24484;171142;297594;64515;114494;25649;65155 trim59;pparg;mrps2;mapkapk3;igfbp3;ehhadh;cdca3;cdc20;ccna2;apoa2;alas1 TRIM59_10085;PPARG_32510;MRPS2_9250;MAPKAPK3_9194;IGFBP3_8881;EHHADH_8534;CDCA3_8260;CDC20_8255;CCNA2_8221;APOA2_33095;ALAS1_8018 25664(0.0441) 52.17498363636364 52.8265 3.54778 32.22451099165207 55.83865181399514 31.445437504286502 32.42201909090909 36.3081 1.51564 18.33016987016894 35.2180417706601 17.9960880235171 143.82269545454545 101.057 8.55785 154.15634882513348 151.99015042135727 154.1444016518779 56.1278;60.1903;63.3158;104.193;50.946;7.29984;46.7245;101.569;52.8265;3.54778;27.1843 33.6269;43.9036;45.3429;59.1667;36.3081;5.26587;21.1123;51.5499;37.3288;1.51564;21.5215 121.883;101.057;111.245;434.985;85.0816;11.8779;127.486;453.17;90.0448;8.55785;36.6615 5 6 5 25664;362094;171142;25649;65155 PPARG_32510;MRPS2_9250;EHHADH_8534;APOA2_33095;ALAS1_8018 32.307604 27.1843 28.362461705879486 23.509902 21.5215 20.6949796257358 53.87985 36.6615 49.06924439292398 60.1903;63.3158;7.29984;3.54778;27.1843 43.9036;45.3429;5.26587;1.51564;21.5215 101.057;111.245;11.8779;8.55785;36.6615 6 365813;315994;24484;297594;64515;114494 TRIM59_10085;MAPKAPK3_9194;IGFBP3_8881;CDCA3_8260;CDC20_8255;CCNA2_8221 68.73113333333333 54.47715 26.63934580890954 39.84878333333334 36.81845 13.555459637860546 218.77506666666667 124.6845 175.4165960823396 56.1278;104.193;50.946;46.7245;101.569;52.8265 33.6269;59.1667;36.3081;21.1123;51.5499;37.3288 121.883;434.985;85.0816;127.486;453.17;90.0448 0 Exp 2,5(0.46);Hill,2(0.19);Linear,4(0.37) 1.8675924503518269 21.509467124938965 1.5163835287094116 3.9502921104431152 0.726398570120025 1.7262524366378784 33.13151458695393 71.21845268577337 21.589580929677936 43.254457252140256 52.722114955994556 234.92327595309635 CONFLICT 0.45454545454545453 0.5454545454545454 0.0 GO:0009987 2 cellular process 2111 2325 111 109 92 108 89 89 7 2236 215 0.74637 0.39122 0.85288 3.83 257644;29142;286954;365813;360243;25123;361604;360268;64305;78968;24950;64159;117267;83500;503568;293820;24679;308761;298490;25664;313245;296371;363465;54133;24614;304951;338475;65035;259241;680308;362094;291234;24552;316273;315994;25211;25626;293502;303575;24484;25685;63868;24471;25460;102551184;29455;364975;58868;65030;25315;171142;291075;29740;64526;117543;114027;50549;266682;65210;25086;24303;499353;171521;29277;24894;311849;25413;306575;297594;64515;25599;362485;114494;25612;25649;155423;502970;65155;26760;81633;24763;50681;681337;314304;192272;50559;170465;114628;140668 zwint;vnn1;ugt2b1;trim59;top2a;tagln;sytl2;sult1e1;sult1b1;srebf1;srd5a1;sptan1;slc26a2;slc22a8;slc13a4;psat1;prkar2b;prc1;ppcs;pparg;polr1e;pltp;pir;pdlim1;orm1;nuf2;nrep;nr1i3;nr1d2;mthfd2;mrps2;mki67;me1;mcm3;mapkapk3;lyz2;krt8;kif22;kif18b;igfbp3;igfbp1;hspd1;hspb1;hmmr;loc102551184;gdf15;gcdh;fzd1;ephx2;ephx1;ehhadh;eci2;eci1;ech1;decr1;dao;cyp4a1;cyp3a2;cyp2j4;cyp2e1;cyp2d3;cyp2c24;cyp2c13;cyp2c11;cyp2a1;crat;cpt2;ckap2;cdca3;cdc20;cd74;ccne2;ccna2;asns;apoa2;anxa7;angptl3;alas1;akr7a3;acta2;acsm3;acox1;acot4;acot3;acot2;acot1;acaa2;abcg5;abcc3 ZWINT_10214;VNN1_10157;UGT2B10_33303,UGT2B1_33224;TRIM59_10085;TOP2A_10059;TAGLN_9981;SYTL2_32351;SULT1E1_32446;SULT1B1_32942;SREBF1_32750;SRD5A1_32503;SPTAN1_9932;SLC26A2_33072;SLC22A8_9848;SLC13A4_9836;PSAT1_9583;PRKAR2B_33052;PRC1_9556;PPCS_9540;PPARG_32510;POLR1E_9523;PLTP_32412;PIR_9487;PDLIM1_9452;ORM1_9400;NUF2_33136;NREP_9364;NR1I3_32602;NR1D2_9358;MTHFD2_9261;MRPS2_9250;MKI67_9232;ME1_9215;MCM3_9207;MAPKAPK3_9194;LYZ2_32611;KRT8_8978;KIF22_8963;KIF18B_32882;IGFBP3_8881;IGFBP1_32306;HSPD1_8849;HSPB1_8847;HMMR_8814;HIST1H4A_32934;GDF15_33113;GCDH_8693;FZD1_8671;EPHX2_33282;EPHX1_8567;EHHADH_8534;ECI2_8521;ECI1_8520;ECH1_8516;DECR1_8458;DAO_8437;CYP4A1_33111;CYP3A2_32374;CYP2J4_32580;CYP2E1_8421;CYP2D3_8420;CYP2C24_32875;CYP2C13_8419;CYP2C11_32593;CYP2A1_32717;CRAT_8375;CPT2_8374;CKAP2_8324;CDCA3_8260;CDC20_8255;CD74_8252;CCNE2_8227;CCNA2_8221;ASNS_8091;APOA2_33095;ANXA7_8051;ANGPTL3_8045;ALAS1_8018;AKR7A3_8015;ACTA2_33040;ACSM3_7976;ACOX1_7973;ACOT4_7971;ACOT3_7970;ACOT2_7969;ACOT1_7968;ACAA2_7955;ABCG5_7947;ABCC3_7941 25664(0.0441) 45.800821348314614 47.5519 5.73955E-13 28.817128166897437 47.166828263575496 28.201692232688643 30.177259606741593 33.259 5.73955E-13 17.552405007249426 31.105782380048375 17.447915985512264 91.19614494382023 74.9097 5.73957E-13 87.28525150876365 91.64819133821759 81.59976952770191 59.0663;20.7328;12.54415;56.1278;54.9577;45.9044;67.0093;59.2729;15.4629;41.2009;29.2087;47.5519;54.7452;52.4905;65.6237;26.3316;108.746;80.3005;15.1091;60.1903;73.982;87.0256;52.1607;67.1147;24.2519;5.73955E-13;69.4104;22.095;99.0234;57.4184;63.3158;49.7822;49.3339;54.0045;104.193;77.8257;68.9539;73.9175;65.9823;50.946;98.8371;34.4455;41.6322;103.573;58.3303;21.3654;15.9021;25.231;6.44145;34.0134;7.29984;8.72912;11.7653;9.87438;21.6199;6.1336;23.208;23.2485;16.3155;7.89174;12.8059;58.9435;104.635;54.426;9.37187;8.98517;31.2175;64.2131;46.7245;101.569;94.9138;77.8893;52.8265;28.1893;3.54778;64.7676;58.0729;27.1843;18.819;90.3558;52.2057;23.8014;12.3157;30.8838;13.6362;28.5134;78.3988;33.1119;34.7775 40.5797;16.8296;7.348245;33.6269;18.8326;35.0852;44.4373;45.3114;7.69418;31.4864;22.9308;34.4152;38.3503;37.1479;42.6891;20.9188;59.3814;50.2731;7.94061;43.9036;47.589;56.6266;40.9644;47.2419;19.7133;5.73955E-13;43.1468;12.9529;42.5557;46.387;45.3429;35.6665;35.4173;33.259;59.1667;49.2403;45.3374;47.5608;43.9552;36.3081;57.328;26.6907;30.9494;58.9579;40.2068;17.8875;10.4227;13.6792;2.66377;26.1579;5.26587;5.10151;8.40998;6.59127;17.4928;2.43617;18.863;18.6955;8.2378;4.16797;8.8664;48.1505;49.2461;43.9518;4.95906;1.97988;24.8356;43.1133;21.1123;51.5499;58.8146;49.2672;37.3288;23.1774;1.51564;43.3787;40.0757;21.5215;11.5469;70.2676;42.2655;19.0993;6.70485;24.6874;11.3249;24.741;43.6084;24.2098;26.6562 108.188;26.7838;25.495849999999997;121.883;218.525;67.7714;135.846;91.5578;35.0879;60.0774;39.9852;76.6397;95.3373;89.1422;135.744;35.2954;147.467;198.961;30.6311;101.057;165.722;104.563;74.9097;123.914;31.358;5.73957E-13;157.944;55.8619;102.838;79.7903;111.245;82.1147;80.9924;111.753;434.985;185.119;143.578;165.416;131.93;85.0816;357.409;48.4857;63.3196;424.786;105.902;26.3528;31.2818;131.659;17.3473;48.3681;11.8779;17.7951;18.8402;19.44;28.0829;16.2027;29.9853;30.5145;36.8422;15.8079;22.6004;80.4167;108.327;74.8861;19.1079;31.3726;42.0237;125.437;127.486;453.17;118.773;185.461;90.0448;35.9474;8.55785;127.439;105.112;36.6615;51.6405;103.57;71.1126;31.3543;24.3993;41.2585;16.9658;33.4642;98.7727;50.4329;49.7705 64 26 63 257644;29142;286954;25123;360268;64305;78968;64159;83500;293820;24679;298490;25664;313245;296371;363465;54133;24614;65035;259241;680308;362094;24552;25626;25685;63868;24471;29455;364975;58868;65030;25315;171142;291075;29740;64526;117543;114027;50549;266682;65210;25086;24303;499353;171521;29277;24894;311849;25413;25599;25612;25649;155423;502970;65155;26760;24763;50681;681337;314304;192272;50559;140668 ZWINT_10214;VNN1_10157;UGT2B10_33303,UGT2B1_33224;TAGLN_9981;SULT1E1_32446;SULT1B1_32942;SREBF1_32750;SPTAN1_9932;SLC22A8_9848;PSAT1_9583;PRKAR2B_33052;PPCS_9540;PPARG_32510;POLR1E_9523;PLTP_32412;PIR_9487;PDLIM1_9452;ORM1_9400;NR1I3_32602;NR1D2_9358;MTHFD2_9261;MRPS2_9250;ME1_9215;KRT8_8978;IGFBP1_32306;HSPD1_8849;HSPB1_8847;GDF15_33113;GCDH_8693;FZD1_8671;EPHX2_33282;EPHX1_8567;EHHADH_8534;ECI2_8521;ECI1_8520;ECH1_8516;DECR1_8458;DAO_8437;CYP4A1_33111;CYP3A2_32374;CYP2J4_32580;CYP2E1_8421;CYP2D3_8420;CYP2C24_32875;CYP2C13_8419;CYP2C11_32593;CYP2A1_32717;CRAT_8375;CPT2_8374;CD74_8252;ASNS_8091;APOA2_33095;ANXA7_8051;ANGPTL3_8045;ALAS1_8018;AKR7A3_8015;ACSM3_7976;ACOX1_7973;ACOT4_7971;ACOT3_7970;ACOT2_7969;ACOT1_7968;ABCC3_7941 38.33724444444445 28.5134 27.637973498961575 26.13826357142857 24.6874 17.19636072205631 64.29793174603176 48.3681 54.803653777546764 59.0663;20.7328;12.54415;45.9044;59.2729;15.4629;41.2009;47.5519;52.4905;26.3316;108.746;15.1091;60.1903;73.982;87.0256;52.1607;67.1147;24.2519;22.095;99.0234;57.4184;63.3158;49.3339;68.9539;98.8371;34.4455;41.6322;21.3654;15.9021;25.231;6.44145;34.0134;7.29984;8.72912;11.7653;9.87438;21.6199;6.1336;23.208;23.2485;16.3155;7.89174;12.8059;58.9435;104.635;54.426;9.37187;8.98517;31.2175;94.9138;28.1893;3.54778;64.7676;58.0729;27.1843;18.819;52.2057;23.8014;12.3157;30.8838;13.6362;28.5134;34.7775 40.5797;16.8296;7.348245;35.0852;45.3114;7.69418;31.4864;34.4152;37.1479;20.9188;59.3814;7.94061;43.9036;47.589;56.6266;40.9644;47.2419;19.7133;12.9529;42.5557;46.387;45.3429;35.4173;45.3374;57.328;26.6907;30.9494;17.8875;10.4227;13.6792;2.66377;26.1579;5.26587;5.10151;8.40998;6.59127;17.4928;2.43617;18.863;18.6955;8.2378;4.16797;8.8664;48.1505;49.2461;43.9518;4.95906;1.97988;24.8356;58.8146;23.1774;1.51564;43.3787;40.0757;21.5215;11.5469;42.2655;19.0993;6.70485;24.6874;11.3249;24.741;26.6562 108.188;26.7838;25.495849999999997;67.7714;91.5578;35.0879;60.0774;76.6397;89.1422;35.2954;147.467;30.6311;101.057;165.722;104.563;74.9097;123.914;31.358;55.8619;102.838;79.7903;111.245;80.9924;143.578;357.409;48.4857;63.3196;26.3528;31.2818;131.659;17.3473;48.3681;11.8779;17.7951;18.8402;19.44;28.0829;16.2027;29.9853;30.5145;36.8422;15.8079;22.6004;80.4167;108.327;74.8861;19.1079;31.3726;42.0237;118.773;35.9474;8.55785;127.439;105.112;36.6615;51.6405;71.1126;31.3543;24.3993;41.2585;16.9658;33.4642;49.7705 26 365813;360243;361604;24950;117267;503568;308761;304951;338475;291234;316273;315994;25211;293502;303575;24484;25460;102551184;306575;297594;64515;362485;114494;81633;170465;114628 TRIM59_10085;TOP2A_10059;SYTL2_32351;SRD5A1_32503;SLC26A2_33072;SLC13A4_9836;PRC1_9556;NUF2_33136;NREP_9364;MKI67_9232;MCM3_9207;MAPKAPK3_9194;LYZ2_32611;KIF22_8963;KIF18B_32882;IGFBP3_8881;HMMR_8814;HIST1H4A_32934;CKAP2_8324;CDCA3_8260;CDC20_8255;CCNE2_8227;CCNA2_8221;ACTA2_33040;ACAA2_7955;ABCG5_7947 63.885642307692336 64.91839999999999 23.414014549601152 39.96405769230772 42.9012 14.504155935404738 156.37258461538465 126.4615 114.57837021672695 56.1278;54.9577;67.0093;29.2087;54.7452;65.6237;80.3005;5.73955E-13;69.4104;49.7822;54.0045;104.193;77.8257;73.9175;65.9823;50.946;103.573;58.3303;64.2131;46.7245;101.569;77.8893;52.8265;90.3558;78.3988;33.1119 33.6269;18.8326;44.4373;22.9308;38.3503;42.6891;50.2731;5.73955E-13;43.1468;35.6665;33.259;59.1667;49.2403;47.5608;43.9552;36.3081;58.9579;40.2068;43.1133;21.1123;51.5499;49.2672;37.3288;70.2676;43.6084;24.2098 121.883;218.525;135.846;39.9852;95.3373;135.744;198.961;5.73957E-13;157.944;82.1147;111.753;434.985;185.119;165.416;131.93;85.0816;424.786;105.902;125.437;127.486;453.17;185.461;90.0448;103.57;98.7727;50.4329 0 Exp 2,27(0.3);Exp 4,6(0.07);Hill,9(0.1);Linear,34(0.38);Poly 2,11(0.13);Power,3(0.04) 2.0711191831733045 237.67898786067963 1.5062377452850342 50.888092041015625 5.197754063650966 1.8113576173782349 39.81378677441718 51.787855922212046 26.530579235788878 33.82393997769427 73.06179735901836 109.33049252862202 UP 0.7078651685393258 0.29213483146067415 0.0 GO:0006796 5 phosphate-containing compound metabolic process 383 419 25 23 20 23 17 17 79 402 2049 0.69189 0.41049 0.67622 4.06 360268;64305;24679;298490;315994;24484;364975;65030;114494;25649;502970;24763;681337;314304;192272;50559;170465 sult1e1;sult1b1;prkar2b;ppcs;mapkapk3;igfbp3;gcdh;ephx2;ccna2;apoa2;angptl3;acsm3;acot4;acot3;acot2;acot1;acaa2 SULT1E1_32446;SULT1B1_32942;PRKAR2B_33052;PPCS_9540;MAPKAPK3_9194;IGFBP3_8881;GCDH_8693;EPHX2_33282;CCNA2_8221;APOA2_33095;ANGPTL3_8045;ACSM3_7976;ACOT4_7971;ACOT3_7970;ACOT2_7969;ACOT1_7968;ACAA2_7955 41.55730764705883 30.8838 3.54778 32.92526925550676 42.59425446654907 33.50501545701136 27.125944117647055 24.741 1.51564 19.704064072159735 27.34583273106407 20.387607926186924 80.18395588235295 41.2585 8.55785 99.52270767431969 88.65744878533474 110.61856993137096 59.2729;15.4629;108.746;15.1091;104.193;50.946;15.9021;6.44145;52.8265;3.54778;58.0729;52.2057;12.3157;30.8838;13.6362;28.5134;78.3988 45.3114;7.69418;59.3814;7.94061;59.1667;36.3081;10.4227;2.66377;37.3288;1.51564;40.0757;42.2655;6.70485;24.6874;11.3249;24.741;43.6084 91.5578;35.0879;147.467;30.6311;434.985;85.0816;31.2818;17.3473;90.0448;8.55785;105.112;71.1126;24.3993;41.2585;16.9658;33.4642;98.7727 13 4 13 360268;64305;24679;298490;364975;65030;25649;502970;24763;681337;314304;192272;50559 SULT1E1_32446;SULT1B1_32942;PRKAR2B_33052;PPCS_9540;GCDH_8693;EPHX2_33282;APOA2_33095;ANGPTL3_8045;ACSM3_7976;ACOT4_7971;ACOT3_7970;ACOT2_7969;ACOT1_7968 32.31614846153846 15.9021 29.91560160525826 21.902234615384614 11.3249 19.084412877603206 50.326396153846154 33.4642 41.36887281676115 59.2729;15.4629;108.746;15.1091;15.9021;6.44145;3.54778;58.0729;52.2057;12.3157;30.8838;13.6362;28.5134 45.3114;7.69418;59.3814;7.94061;10.4227;2.66377;1.51564;40.0757;42.2655;6.70485;24.6874;11.3249;24.741 91.5578;35.0879;147.467;30.6311;31.2818;17.3473;8.55785;105.112;71.1126;24.3993;41.2585;16.9658;33.4642 4 315994;24484;114494;170465 MAPKAPK3_9194;IGFBP3_8881;CCNA2_8221;ACAA2_7955 71.591075 65.61265 25.08358713094744 44.103 40.4686 10.54845863147785 177.221025 94.40875 171.93581588070154 104.193;50.946;52.8265;78.3988 59.1667;36.3081;37.3288;43.6084 434.985;85.0816;90.0448;98.7727 0 Exp 2,4(0.24);Exp 4,2(0.12);Hill,3(0.18);Linear,5(0.3);Poly 2,2(0.12);Power,1(0.06) 2.507305043264348 85.78296601772308 1.5163835287094116 50.888092041015625 11.837404070963471 1.9018945693969727 25.905628160645996 57.208987133471645 17.759226626472525 36.4926616088216 32.873863744598175 127.49404802010773 UP 0.7647058823529411 0.23529411764705882 0.0 GO:0044087 5 regulation of cellular component biogenesis 211 228 4 4 2 4 2 2 94 226 2225 0.0060117 0.99889 0.010143 0.88 64159;58868 sptan1;fzd1 SPTAN1_9932;FZD1_8671 36.391450000000006 36.391450000000006 25.231 15.78325975218679 33.38647735148515 15.200380494196715 24.0472 24.0472 13.6792 14.662566214684247 21.255596039603954 14.121074415801454 104.14935 104.14935 76.6397 38.90452012613702 111.55637622387238 37.467767631428686 47.5519;25.231 34.4152;13.6792 76.6397;131.659 2 0 2 64159;58868 SPTAN1_9932;FZD1_8671 36.391450000000006 36.391450000000006 15.78325975218679 24.0472 24.0472 14.662566214684247 104.14935 104.14935 38.90452012613702 47.5519;25.231 34.4152;13.6792 76.6397;131.659 0 0 Linear,1(0.5);Poly 2,1(0.5) 1.5093184199785703 3.0186431407928467 1.5062377452850342 1.5124053955078125 0.00436118729651327 1.5093215703964233 14.516968000000006 58.26593200000001 3.7259200000000057 44.36847999999999 50.230436000000026 158.06826399999997 UP 1.0 0.0 0.0 GO:0007346 6 regulation of mitotic cell cycle 146 155 6 6 4 6 4 4 92 151 2300 0.29365 0.84779 0.66043 2.58 257644;360243;291234;25612 zwint;top2a;mki67;asns ZWINT_10214;TOP2A_10059;MKI67_9232;ASNS_8091 47.998875 52.36995 28.1893 13.741817580503437 51.43140788834952 12.207535738821871 29.56405 29.42195 18.8326 10.239429643132798 31.802834117111654 10.678617605254788 111.193775 95.15135000000001 35.9474 77.5384551837506 117.46691438106797 70.30962847189485 59.0663;54.9577;49.7822;28.1893 40.5797;18.8326;35.6665;23.1774 108.188;218.525;82.1147;35.9474 2 2 2 257644;25612 ZWINT_10214;ASNS_8091 43.6278 43.6278 21.83333608269702 31.87855 31.87855 12.305284338242657 72.0677 72.0677 51.08181813698491 59.0663;28.1893 40.5797;23.1774 108.188;35.9474 2 360243;291234 TOP2A_10059;MKI67_9232 52.36995 52.36995 3.659631146030959 27.24955 27.24955 11.903364843816222 150.31985 150.31985 96.45664815369132 54.9577;49.7822 18.8326;35.6665 218.525;82.1147 0 Exp 2,2(0.5);Linear,2(0.5) 2.1434005644321137 8.92060399055481 1.5678966045379639 3.2609751224517822 0.7492375759826232 2.0458661317825317 34.53189377110663 61.465856228893365 19.529408949729856 39.59869105027014 35.20608891992441 187.1814610800756 CONFLICT 0.5 0.5 0.0 GO:0032270 7 positive regulation of cellular protein metabolic process 403 428 15 15 10 14 10 10 86 418 2033 0.052716 0.97342 0.095248 2.34 78968;25664;24484;63868;29455;299626;58868;64515;25599;81633 srebf1;pparg;igfbp3;hspd1;gdf15;gadd45b;fzd1;cdc20;cd74;acta2 SREBF1_32750;PPARG_32510;IGFBP3_8881;HSPD1_8849;GDF15_33113;GADD45B_8679;FZD1_8671;CDC20_8255;CD74_8252;ACTA2_33040 25664(0.0441) 57.278949999999995 51.7589 21.3654 29.13480592884853 60.428011412846466 26.469101820405825 38.777939999999994 36.74995 13.6792 17.81604424433214 41.03566058069407 15.996211549454973 121.75865000000002 95.2085 26.3528 120.81687510094909 119.50255746794977 108.27229445584057 41.2009;60.1903;50.946;34.4455;21.3654;52.5718;25.231;101.569;94.9138;90.3558 31.4864;43.9036;36.3081;26.6907;17.8875;37.1918;13.6792;51.5499;58.8146;70.2676 60.0774;101.057;85.0816;48.4857;26.3528;89.36;131.659;453.17;118.773;103.57 7 3 7 78968;25664;63868;29455;299626;58868;25599 SREBF1_32750;PPARG_32510;HSPD1_8849;GDF15_33113;GADD45B_8679;FZD1_8671;CD74_8252 47.13124285714286 41.2009 25.24185590171328 32.80768571428571 31.4864 15.526179934809953 82.25212857142857 89.36 38.590981762527285 41.2009;60.1903;34.4455;21.3654;52.5718;25.231;94.9138 31.4864;43.9036;26.6907;17.8875;37.1918;13.6792;58.8146 60.0774;101.057;48.4857;26.3528;89.36;131.659;118.773 3 24484;64515;81633 IGFBP3_8881;CDC20_8255;ACTA2_33040 80.95693333333334 90.3558 26.588081036685068 52.70853333333334 51.5499 17.009371930301604 213.94053333333332 103.57 207.38492839368377 50.946;101.569;90.3558 36.3081;51.5499;70.2676 85.0816;453.17;103.57 0 Exp 2,5(0.5);Linear,2(0.2);Poly 2,3(0.3) 1.8209642252057434 19.698286414146423 1.5124053955078125 5.015069484710693 1.0769720630764934 1.628197193145752 39.221010199260775 75.33688980073923 27.735441373541107 49.820438626458895 46.87557499979543 196.6417250002046 UP 0.7 0.3 0.0 GO:0046456 6 icosanoid biosynthetic process 13 16 3 3 3 3 3 3 93 13 2438 0.99757 0.020339 0.020339 18.75 50549;29277;25599 cyp4a1;cyp2c11;cd74 CYP4A1_33111;CYP2C11_32593;CD74_8252 57.51593333333333 54.426 23.208 35.95262444402818 69.18177030472637 28.313920532641855 40.54313333333334 43.9518 18.863 20.19274230938763 48.42633211028192 13.178263406365966 74.54813333333333 74.8861 29.9853 44.3948148315018 90.11592139821725 32.68147356652559 0.0 23.208 0.5 38.817 23.208;54.426;94.9138 18.863;43.9518;58.8146 29.9853;74.8861;118.773 3 0 3 50549;29277;25599 CYP4A1_33111;CYP2C11_32593;CD74_8252 57.51593333333333 54.426 35.95262444402818 40.54313333333334 43.9518 20.19274230938763 74.54813333333333 74.8861 44.3948148315018 23.208;54.426;94.9138 18.863;43.9518;58.8146 29.9853;74.8861;118.773 0 0 Exp 2,2(0.67);Poly 2,1(0.34) 2.151553703855501 6.641796708106995 1.6577342748641968 2.9415390491485596 0.6588432442635649 2.0425233840942383 16.831708827700275 98.20015783896639 17.69289432565001 63.39337234101665 24.310671077894646 124.785595588772 UP 1.0 0.0 0.0 GO:0048522 5 positive regulation of cellular process 1060 1140 38 37 28 37 27 27 69 1113 1338 4.8815E-4 0.99978 7.6576E-4 2.37 29142;360243;360268;78968;309607;308761;25664;54133;24614;65035;259241;24484;25685;63868;24471;29455;299626;58868;65210;306575;64515;25599;114494;25612;25649;502970;81633 vnn1;top2a;sult1e1;srebf1;rt1-ce5;prc1;pparg;pdlim1;orm1;nr1i3;nr1d2;igfbp3;igfbp1;hspd1;hspb1;gdf15;gadd45b;fzd1;cyp2j4;ckap2;cdc20;cd74;ccna2;asns;apoa2;angptl3;acta2 VNN1_10157;TOP2A_10059;SULT1E1_32446;SREBF1_32750;RT1-CE5_32445;PRC1_9556;PPARG_32510;PDLIM1_9452;ORM1_9400;NR1I3_32602;NR1D2_9358;IGFBP3_8881;IGFBP1_32306;HSPD1_8849;HSPB1_8847;GDF15_33113;GADD45B_8679;FZD1_8671;CYP2J4_32580;CKAP2_8324;CDC20_8255;CD74_8252;CCNA2_8221;ASNS_8091;APOA2_33095;ANGPTL3_8045;ACTA2_33040 25664(0.0441) 52.555310370370364 52.8265 3.54778 28.1054563316227 52.27543615980335 25.89874835779021 33.696523703703704 36.3081 1.51564 16.951608868634576 34.29959973950742 16.54127966372164 112.51406851851851 91.5578 8.55785 99.13226009440345 104.73662831112124 83.04690445513886 20.7328;54.9577;59.2729;41.2009;54.8206;80.3005;60.1903;67.1147;24.2519;22.095;99.0234;50.946;98.8371;34.4455;41.6322;21.3654;52.5718;25.231;16.3155;64.2131;101.569;94.9138;52.8265;28.1893;3.54778;58.0729;90.3558 16.8296;18.8326;45.3114;31.4864;26.5902;50.2731;43.9036;47.2419;19.7133;12.9529;42.5557;36.3081;57.328;26.6907;30.9494;17.8875;37.1918;13.6792;8.2378;43.1133;51.5499;58.8146;37.3288;23.1774;1.51564;40.0757;70.2676 26.7838;218.525;91.5578;60.0774;147.824;198.961;101.057;123.914;31.358;55.8619;102.838;85.0816;357.409;48.4857;63.3196;26.3528;89.36;131.659;36.8422;125.437;453.17;118.773;90.0448;35.9474;8.55785;105.112;103.57 19 8 19 29142;360268;78968;25664;54133;24614;65035;259241;25685;63868;24471;29455;299626;58868;65210;25599;25612;25649;502970 VNN1_10157;SULT1E1_32446;SREBF1_32750;PPARG_32510;PDLIM1_9452;ORM1_9400;NR1I3_32602;NR1D2_9358;IGFBP1_32306;HSPD1_8849;HSPB1_8847;GDF15_33113;GADD45B_8679;FZD1_8671;CYP2J4_32580;CD74_8252;ASNS_8091;APOA2_33095;ANGPTL3_8045 45.737062105263156 41.2009 28.775053872364975 30.29171263157895 30.9494 16.566240845215855 85.01402368421053 63.3196 75.87617162842503 20.7328;59.2729;41.2009;60.1903;67.1147;24.2519;22.095;99.0234;98.8371;34.4455;41.6322;21.3654;52.5718;25.231;16.3155;94.9138;28.1893;3.54778;58.0729 16.8296;45.3114;31.4864;43.9036;47.2419;19.7133;12.9529;42.5557;57.328;26.6907;30.9494;17.8875;37.1918;13.6792;8.2378;58.8146;23.1774;1.51564;40.0757 26.7838;91.5578;60.0774;101.057;123.914;31.358;55.8619;102.838;357.409;48.4857;63.3196;26.3528;89.36;131.659;36.8422;118.773;35.9474;8.55785;105.112 8 360243;309607;308761;24484;306575;64515;114494;81633 TOP2A_10059;RT1-CE5_32445;PRC1_9556;IGFBP3_8881;CKAP2_8324;CDC20_8255;CCNA2_8221;ACTA2_33040 68.74865 59.5854 19.466787994721372 41.78295 40.221050000000005 15.982010996742568 177.826675 136.6305 121.5278679528486 54.9577;54.8206;80.3005;50.946;64.2131;101.569;52.8265;90.3558 18.8326;26.5902;50.2731;36.3081;43.1133;51.5499;37.3288;70.2676 218.525;147.824;198.961;85.0816;125.437;453.17;90.0448;103.57 0 Exp 2,11(0.41);Exp 4,1(0.04);Hill,1(0.04);Linear,9(0.34);Poly 2,4(0.15);Power,1(0.04) 2.0856476837555964 60.02093827724457 1.5124053955078125 5.015069484710693 0.9302076166437413 1.8468482494354248 41.953871088247396 63.15674965249332 27.302339953948135 40.090707453459274 75.12116431194372 149.90697272509334 UP 0.7037037037037037 0.2962962962962963 0.0 GO:0032094 4 response to food 10 10 2 2 2 2 2 2 94 8 2443 0.99486 0.051951 0.051951 20.0 78968;25664 srebf1;pparg SREBF1_32750;PPARG_32510 25664(0.0441) 50.6956 50.6956 41.2009 13.427533510663821 50.507461955085866 13.424897181435362 37.695 37.695 31.4864 8.780286323349577 37.571976221928665 8.77856242331611 80.5672 80.5672 60.0774 28.976953050312247 80.1611933949802 28.97126378591997 0.0 41.2009 0.0 41.2009 41.2009;60.1903 31.4864;43.9036 60.0774;101.057 2 0 2 78968;25664 SREBF1_32750;PPARG_32510 50.6956 50.6956 13.427533510663821 37.695 37.695 8.780286323349577 80.5672 80.5672 28.976953050312247 41.2009;60.1903 31.4864;43.9036 60.0774;101.057 0 0 Exp 2,2(1) 1.7072478335568573 3.436534881591797 1.5239794254302979 1.912555456161499 0.27476474633658465 1.7182674407958984 32.085988 69.305212 25.526144000000002 49.863856 40.407191999999995 120.727208 UP 1.0 0.0 0.0 GO:0051256 5 mitotic spindle midzone assembly 3 4 1 1 1 1 1 1 95 3 2448 0.99197 0.14253 0.14253 25.0 308761 prc1 PRC1_9556 80.3005 80.3005 80.3005 80.3005 50.2731 50.2731 50.2731 50.2731 198.961 198.961 198.961 198.961 0.0 80.3005 0.0 80.3005 80.3005 50.2731 198.961 0 1 0 1 308761 PRC1_9556 80.3005 80.3005 50.2731 50.2731 198.961 198.961 80.3005 50.2731 198.961 0 Linear,1(1) 1.7985904216766357 1.7985904216766357 1.7985904216766357 1.7985904216766357 0.0 1.7985904216766357 80.3005 80.3005 50.2731 50.2731 198.961 198.961 DOWN 0.0 1.0 0.0 GO:0015939 5 pantothenate metabolic process 1 1 1 1 1 1 1 1 95 0 2451 1.0 0.037691 0.037691 100.0 29142 vnn1 VNN1_10157 20.7328 20.7328 20.7328 20.7328 16.8296 16.8296 16.8296 16.8296 26.7838 26.7838 26.7838 26.7838 0.0 20.7328 0.0 20.7328 20.7328 16.8296 26.7838 1 0 1 29142 VNN1_10157 20.7328 20.7328 16.8296 16.8296 26.7838 26.7838 20.7328 16.8296 26.7838 0 0 Linear,1(1) 4.608505725860597 4.608505725860596 4.608505725860596 4.608505725860596 0.0 4.608505725860596 20.7328 20.7328 16.8296 16.8296 26.7838 26.7838 UP 1.0 0.0 0.0 GO:0048146 7 positive regulation of fibroblast proliferation 27 30 3 3 2 3 2 2 94 28 2423 0.89876 0.3133 0.3133 6.67 25599;114494 cd74;ccna2 CD74_8252;CCNA2_8221 73.87015 73.87015 52.8265 29.76021523183258 81.34341395309742 27.820335411703194 48.0717 48.0717 37.3288 15.192754879217913 51.886842683029336 14.202435475518106 104.40889999999999 104.40889999999999 90.0448 20.313905031283365 109.51004503656384 18.989770305400665 0.5 73.87015 94.9138;52.8265 58.8146;37.3288 118.773;90.0448 1 1 1 25599 CD74_8252 94.9138 94.9138 58.8146 58.8146 118.773 118.773 94.9138 58.8146 118.773 1 114494 CCNA2_8221 52.8265 52.8265 37.3288 37.3288 90.0448 90.0448 52.8265 37.3288 90.0448 0 Linear,1(0.5);Poly 2,1(0.5) 1.963472311138928 3.9833322763442993 1.6577342748641968 2.3255980014801025 0.4722509699986255 1.9916661381721497 32.62459600000001 115.11570399999998 27.015616000000005 69.12778399999999 76.25526399999998 132.562536 CONFLICT 0.5 0.5 0.0 GO:0009628 3 response to abiotic stimulus 422 443 19 19 15 19 15 15 81 428 2023 0.38083 0.72069 0.78349 3.39 360243;25664;54133;291234;25626;24484;63868;24471;114494;25612;155423;65155;192272;170465;114628 top2a;pparg;pdlim1;mki67;krt8;igfbp3;hspd1;hspb1;ccna2;asns;anxa7;alas1;acot2;acaa2;abcg5 TOP2A_10059;PPARG_32510;PDLIM1_9452;MKI67_9232;KRT8_8978;IGFBP3_8881;HSPD1_8849;HSPB1_8847;CCNA2_8221;ASNS_8091;ANXA7_8051;ALAS1_8018;ACOT2_7969;ACAA2_7955;ABCG5_7947 25664(0.0441) 48.409139999999994 50.946 13.6362 18.306685504005692 49.31962193353826 19.407870812264886 32.63197999999999 35.6665 11.3249 11.177120593758886 33.29556936263991 11.860341873707972 88.15598 85.0816 16.9658 51.600946548131674 88.14921852229888 50.139002276493876 54.9577;60.1903;67.1147;49.7822;68.9539;50.946;34.4455;41.6322;52.8265;28.1893;64.7676;27.1843;13.6362;78.3988;33.1119 18.8326;43.9036;47.2419;35.6665;45.3374;36.3081;26.6907;30.9494;37.3288;23.1774;43.3787;21.5215;11.3249;43.6084;24.2098 218.525;101.057;123.914;82.1147;143.578;85.0816;48.4857;63.3196;90.0448;35.9474;127.439;36.6615;16.9658;98.7727;50.4329 9 6 9 25664;54133;25626;63868;24471;25612;155423;65155;192272 PPARG_32510;PDLIM1_9452;KRT8_8978;HSPD1_8849;HSPB1_8847;ASNS_8091;ANXA7_8051;ALAS1_8018;ACOT2_7969 45.12377777777777 41.6322 20.58713468168762 32.61394444444444 30.9494 12.856755669988367 77.48533333333333 63.3196 46.99880301840145 60.1903;67.1147;68.9539;34.4455;41.6322;28.1893;64.7676;27.1843;13.6362 43.9036;47.2419;45.3374;26.6907;30.9494;23.1774;43.3787;21.5215;11.3249 101.057;123.914;143.578;48.4857;63.3196;35.9474;127.439;36.6615;16.9658 6 360243;291234;24484;114494;170465;114628 TOP2A_10059;MKI67_9232;IGFBP3_8881;CCNA2_8221;ACAA2_7955;ABCG5_7947 53.337183333333336 51.886250000000004 14.549152908869543 32.65903333333333 35.987300000000005 9.237052528305043 104.16194999999999 87.5632 58.38526688741778 54.9577;49.7822;50.946;52.8265;78.3988;33.1119 18.8326;35.6665;36.3081;37.3288;43.6084;24.2098 218.525;82.1147;85.0816;90.0448;98.7727;50.4329 0 Exp 2,6(0.4);Linear,8(0.54);Poly 2,1(0.07) 2.0177796121244382 31.81779408454895 1.5239794254302979 4.473705768585205 0.802445752934567 1.8061060905456543 39.14467889071396 57.67360110928604 26.9755765493578 38.288383450642186 62.04229806708481 114.26966193291523 UP 0.6 0.4 0.0 GO:0044843 5 cell cycle G1/S phase transition 24 26 3 3 2 3 2 2 94 24 2427 0.92789 0.25657 0.25657 7.69 362485;114494 ccne2;ccna2 CCNE2_8227;CCNA2_8221 65.3579 65.3579 52.8265 17.72207583552222 62.89305903915147 17.37587666839992 43.298 43.298 37.3288 8.441723596517472 42.123899048510374 8.276815280735836 137.7529 137.7529 90.0448 67.46944205505184 128.36904192793637 66.15143253616466 0.5 65.3579 77.8893;52.8265 49.2672;37.3288 185.461;90.0448 0 2 0 2 362485;114494 CCNE2_8227;CCNA2_8221 65.3579 65.3579 17.72207583552222 43.298 43.298 8.441723596517472 137.7529 137.7529 67.46944205505184 77.8893;52.8265 49.2672;37.3288 185.461;90.0448 0 Linear,2(1) 1.922809129883272 3.9153804779052734 1.589782476425171 2.3255980014801025 0.5203001474686821 1.9576902389526367 40.796356 89.919444 31.598368 54.997632 44.24502399999999 231.26077600000002 DOWN 0.0 1.0 0.0 GO:0043627 3 response to estrogen 45 49 5 5 4 5 4 4 92 45 2406 0.96479 0.11073 0.11073 8.16 24950;25664;63868;25649 srd5a1;pparg;hspd1;apoa2 SRD5A1_32503;PPARG_32510;HSPD1_8849;APOA2_33095 25664(0.0441) 31.84807 31.8271 3.54778 23.222843151078646 34.98973135049439 25.299251755813618 23.760185 24.81075 1.51564 17.415058118026288 25.87723099920731 18.846324927773683 49.521437500000005 44.23545 8.55785 38.40981767242533 55.77705555717802 42.318780049867954 1.5 31.8271 29.2087;60.1903;34.4455;3.54778 22.9308;43.9036;26.6907;1.51564 39.9852;101.057;48.4857;8.55785 3 1 3 25664;63868;25649 PPARG_32510;HSPD1_8849;APOA2_33095 32.72786 34.4455 28.3602976600176 24.036646666666666 26.6907 21.318250105544156 52.700183333333335 48.4857 46.39336795282095 60.1903;34.4455;3.54778 43.9036;26.6907;1.51564 101.057;48.4857;8.55785 1 24950 SRD5A1_32503 29.2087 29.2087 22.9308 22.9308 39.9852 39.9852 29.2087 22.9308 39.9852 0 Exp 2,2(0.5);Hill,1(0.25);Linear,1(0.25) 1.7074614091549822 6.8572845458984375 1.5239794254302979 1.9512832164764404 0.17884038339861114 1.6910109519958496 9.08968371194294 54.60645628805706 6.693428044334237 40.82694195566576 11.879816181023166 87.16305881897685 UP 0.75 0.25 0.0 GO:1905952 5 regulation of lipid localization 57 62 8 8 6 8 6 6 90 56 2395 0.99219 0.027427 0.027427 9.68 78968;25664;296371;24484;25649;114628 srebf1;pparg;pltp;igfbp3;apoa2;abcg5 SREBF1_32750;PPARG_32510;PLTP_32412;IGFBP3_8881;APOA2_33095;ABCG5_7947 25664(0.0441) 46.003746666666665 46.073449999999994 3.54778 27.929385122387977 46.62557121796928 26.783836749787234 32.34169 33.89725 1.51564 18.741779741545358 32.966982588127436 17.879006000104134 68.29495833333333 72.5795 8.55785 36.40224461167768 69.0663922793949 34.97890411497875 2.5 46.073449999999994 41.2009;60.1903;87.0256;50.946;3.54778;33.1119 31.4864;43.9036;56.6266;36.3081;1.51564;24.2098 60.0774;101.057;104.563;85.0816;8.55785;50.4329 4 2 4 78968;25664;296371;25649 SREBF1_32750;PPARG_32510;PLTP_32412;APOA2_33095 47.991145 50.6956 35.089543454540696 33.38306 37.695 23.594305034868047 68.5638125 80.5672 44.812511151990726 41.2009;60.1903;87.0256;3.54778 31.4864;43.9036;56.6266;1.51564 60.0774;101.057;104.563;8.55785 2 24484;114628 IGFBP3_8881;ABCG5_7947 42.028949999999995 42.028949999999995 12.610613046359013 30.258950000000002 30.258950000000002 8.554789970829193 67.75725 67.75725 24.50033072929834 50.946;33.1119 36.3081;24.2098 85.0816;50.4329 0 Exp 2,3(0.5);Hill,1(0.17);Linear,1(0.17);Poly 2,1(0.17) 1.7945461722752196 10.941181778907776 1.5084086656570435 2.5319817066192627 0.37832233886660227 1.7321282625198364 23.655584156020055 68.35190917731327 17.34514290211714 47.33823709788286 39.167096235074354 97.4228204315923 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0045595 5 regulation of cell differentiation 433 456 18 17 13 18 12 12 84 444 2007 0.098089 0.94402 0.17621 2.63 29142;360268;25664;338475;259241;24484;24471;102551184;29455;58868;64515;25599 vnn1;sult1e1;pparg;nrep;nr1d2;igfbp3;hspb1;loc102551184;gdf15;fzd1;cdc20;cd74 VNN1_10157;SULT1E1_32446;PPARG_32510;NREP_9364;NR1D2_9358;IGFBP3_8881;HSPB1_8847;HIST1H4A_32934;GDF15_33113;FZD1_8671;CDC20_8255;CD74_8252 25664(0.0441) 58.55145833333333 58.8016 20.7328 28.918835864079337 63.830450401363 25.64716026912258 36.76188333333332 41.38125 13.6792 14.25625362465913 40.800246643294784 13.047519009373943 122.03654999999999 101.94749999999999 26.3528 111.2253109135645 130.26438300514403 105.36528200409789 20.7328;59.2729;60.1903;69.4104;99.0234;50.946;41.6322;58.3303;21.3654;25.231;101.569;94.9138 16.8296;45.3114;43.9036;43.1468;42.5557;36.3081;30.9494;40.2068;17.8875;13.6792;51.5499;58.8146 26.7838;91.5578;101.057;157.944;102.838;85.0816;63.3196;105.902;26.3528;131.659;453.17;118.773 8 4 8 29142;360268;25664;259241;24471;29455;58868;25599 VNN1_10157;SULT1E1_32446;PPARG_32510;NR1D2_9358;HSPB1_8847;GDF15_33113;FZD1_8671;CD74_8252 52.795225 50.45255 31.41405180337296 33.741375 36.75255 16.436608569440356 82.792625 96.3074 39.99354191286921 20.7328;59.2729;60.1903;99.0234;41.6322;21.3654;25.231;94.9138 16.8296;45.3114;43.9036;42.5557;30.9494;17.8875;13.6792;58.8146 26.7838;91.5578;101.057;102.838;63.3196;26.3528;131.659;118.773 4 338475;24484;102551184;64515 NREP_9364;IGFBP3_8881;HIST1H4A_32934;CDC20_8255 70.063925 63.87035 22.33211333205693 42.8029 41.6768 6.469168892008717 200.5244 131.923 171.19514042666825 69.4104;50.946;58.3303;101.569 43.1468;36.3081;40.2068;51.5499 157.944;85.0816;105.902;453.17 0 Exp 2,5(0.42);Linear,4(0.34);Poly 2,2(0.17);Power,1(0.09) 2.1987063174717645 28.974303603172302 1.5124053955078125 5.015069484710693 1.2178782425470016 1.7924261689186096 42.18908661597206 74.9138300506946 28.695648502857463 44.828118163809194 59.10490606728663 184.96819393271335 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0043410 8 positive regulation of MAPK cascade 143 153 6 6 5 6 5 5 91 148 2303 0.47754 0.69527 1.0 3.27 24484;29455;299626;25599;81633 igfbp3;gdf15;gadd45b;cd74;acta2 IGFBP3_8881;GDF15_33113;GADD45B_8679;CD74_8252;ACTA2_33040 62.030559999999994 52.5718 21.3654 30.617060370453615 70.13535404629398 25.354903638794916 44.093920000000004 37.1918 17.8875 20.59608365192275 48.59281394137039 16.777474550754576 84.62747999999999 89.36 26.3528 35.15422058461829 96.97591508985855 22.41022339605579 50.946;21.3654;52.5718;94.9138;90.3558 36.3081;17.8875;37.1918;58.8146;70.2676 85.0816;26.3528;89.36;118.773;103.57 3 2 3 29455;299626;25599 GDF15_33113;GADD45B_8679;CD74_8252 56.28366666666667 52.5718 36.91443147677252 37.96463333333333 37.1918 20.47449223114783 78.16193333333332 89.36 47.216743479546885 21.3654;52.5718;94.9138 17.8875;37.1918;58.8146 26.3528;89.36;118.773 2 24484;81633 IGFBP3_8881;ACTA2_33040 70.65090000000001 70.65090000000001 27.866936825205553 53.287850000000006 53.287850000000006 24.01299273570454 94.32579999999999 94.32579999999999 13.07327301328945 50.946;90.3558 36.3081;70.2676 85.0816;103.57 0 Exp 2,1(0.2);Linear,2(0.4);Poly 2,2(0.4) 2.0466786959158796 11.564234852790833 1.5528020858764648 5.015069484710693 1.5121633490436293 1.6577342748641968 35.193523322256745 88.86759667774325 26.040656698539205 62.147183301460785 53.81344704609429 115.44151295390571 UP 0.6 0.4 0.0 GO:0043651 8 linoleic acid metabolic process 10 12 4 4 4 4 4 4 92 8 2443 0.99996 7.4374E-4 7.4374E-4 33.33 65030;50549;65210;499353 ephx2;cyp4a1;cyp2j4;cyp2c24 EPHX2_33282;CYP4A1_33111;CYP2J4_32580;CYP2C24_32875 26.2271125 19.76175 6.44145 22.87057464845658 26.401467865200804 24.774966168200645 19.4787675 13.5504 2.66377 20.261218336407076 18.940736620174757 22.115347466216353 41.147875 33.41375 17.3473 27.39616703754683 43.75060120195266 28.695597921580763 0.0 6.44145 0.5 11.378475 6.44145;23.208;16.3155;58.9435 2.66377;18.863;8.2378;48.1505 17.3473;29.9853;36.8422;80.4167 4 0 4 65030;50549;65210;499353 EPHX2_33282;CYP4A1_33111;CYP2J4_32580;CYP2C24_32875 26.2271125 19.76175 22.87057464845658 19.4787675 13.5504 20.261218336407076 41.147875 33.41375 27.39616703754683 6.44145;23.208;16.3155;58.9435 2.66377;18.863;8.2378;48.1505 17.3473;29.9853;36.8422;80.4167 0 0 Exp 2,2(0.5);Exp 4,2(0.5) 2.244193910726821 9.05279290676117 1.940477728843689 2.6958487033843994 0.34268389988222664 2.2082332372665405 3.8139493445125474 48.64027565548746 -0.37722646967893425 39.33476146967894 14.29963130320412 67.99611869679588 UP 1.0 0.0 0.0 GO:0007010 6 cytoskeleton organization 170 184 10 10 9 9 9 9 87 175 2276 0.84895 0.25426 0.41787 4.89 25123;64159;308761;54133;304951;25626;303575;25460;64515 tagln;sptan1;prc1;pdlim1;nuf2;krt8;kif18b;hmmr;cdc20 TAGLN_9981;SPTAN1_9932;PRC1_9556;PDLIM1_9452;NUF2_33136;KRT8_8978;KIF18B_32882;HMMR_8814;CDC20_8255 64.54996666666673 67.1147 5.73955E-13 31.5685740646452 69.01610777417292 25.616228131098957 40.75731111111117 45.3374 5.73955E-13 17.121254613961728 43.80022511624066 13.523815955352784 180.08334444444452 131.93 5.73957E-13 157.0680697796269 184.09441064867437 140.18119589756463 45.9044;47.5519;80.3005;67.1147;5.73955E-13;68.9539;65.9823;103.573;101.569 35.0852;34.4152;50.2731;47.2419;5.73955E-13;45.3374;43.9552;58.9579;51.5499 67.7714;76.6397;198.961;123.914;5.73957E-13;143.578;131.93;424.786;453.17 4 5 4 25123;64159;54133;25626 TAGLN_9981;SPTAN1_9932;PDLIM1_9452;KRT8_8978 57.381225 57.3333 12.342345593761081 40.519925 40.2113 6.713094577701595 102.975775 100.27685 36.60549506402695 45.9044;47.5519;67.1147;68.9539 35.0852;34.4152;47.2419;45.3374 67.7714;76.6397;123.914;143.578 5 308761;304951;303575;25460;64515 PRC1_9556;NUF2_33136;KIF18B_32882;HMMR_8814;CDC20_8255 70.28496000000011 80.3005 42.26577898410223 40.947220000000115 50.2731 23.502639343422445 241.76940000000013 198.961 193.99419143056815 80.3005;5.73955E-13;65.9823;103.573;101.569 50.2731;5.73955E-13;43.9552;58.9579;51.5499 198.961;5.73957E-13;131.93;424.786;453.17 0 Exp 2,3(0.34);Hill,1(0.12);Linear,5(0.56) 1.7241653385052669 15.718814134597778 1.5062377452850342 2.5474231243133545 0.32380300675567136 1.63596773147583 43.925164944431856 85.17476838890161 29.57142476332286 51.9431974588995 77.46553885508827 282.7011500338008 CONFLICT 0.4444444444444444 0.5555555555555556 0.0 GO:0051050 5 positive regulation of transport 286 308 13 13 8 13 8 8 88 300 2151 0.16028 0.91088 0.33659 2.6 361604;309607;25664;296371;24614;63868;65210;25649 sytl2;rt1-ce5;pparg;pltp;orm1;hspd1;cyp2j4;apoa2 SYTL2_32351;RT1-CE5_32445;PPARG_32510;PLTP_32412;ORM1_9400;HSPD1_8849;CYP2J4_32580;APOA2_33095 25664(0.0441) 43.45081 44.63305 3.54778 28.388926488256953 43.38044196255942 28.3017916065324 28.4643925 26.64045 1.51564 18.917880210180414 28.552122189238023 19.044168031375538 76.81671875 74.77135 8.55785 52.11294662258628 76.13783939242415 50.76229011903632 67.0093;54.8206;60.1903;87.0256;24.2519;34.4455;16.3155;3.54778 44.4373;26.5902;43.9036;56.6266;19.7133;26.6907;8.2378;1.51564 135.846;147.824;101.057;104.563;31.358;48.4857;36.8422;8.55785 6 2 6 25664;296371;24614;63868;65210;25649 PPARG_32510;PLTP_32412;ORM1_9400;HSPD1_8849;CYP2J4_32580;APOA2_33095 37.62943 29.3487 30.83476175921909 26.114606666666663 23.201999999999998 21.040095100646926 55.14395833333333 42.66395 39.15500770001734 60.1903;87.0256;24.2519;34.4455;16.3155;3.54778 43.9036;56.6266;19.7133;26.6907;8.2378;1.51564 101.057;104.563;31.358;48.4857;36.8422;8.55785 2 361604;309607 SYTL2_32351;RT1-CE5_32445 60.91495 60.91495 8.618712423848493 35.51375 35.51375 12.619805434514438 141.835 141.835 8.469725025052838 67.0093;54.8206 44.4373;26.5902 135.846;147.824 0 Exp 2,4(0.5);Exp 4,1(0.13);Hill,1(0.13);Linear,1(0.13);Poly 2,1(0.13) 1.8334694175105215 15.29955804347992 1.5084086656570435 3.5849626064300537 0.6945951440251841 1.6910109519958496 23.778287618156163 63.12333238184382 15.354970345352504 41.57381465464749 40.70428916444552 112.92914833555449 UP 0.75 0.25 0.0 GO:1902975 9 mitotic DNA replication initiation 4 4 1 1 1 1 1 1 95 3 2448 0.99197 0.14253 0.14253 25.0 316273 mcm3 MCM3_9207 54.0045 54.0045 54.0045 54.0045 33.259 33.259 33.259 33.259 111.753 111.753 111.753 111.753 0.0 54.0045 0.0 54.0045 54.0045 33.259 111.753 0 1 0 1 316273 MCM3_9207 54.0045 54.0045 33.259 33.259 111.753 111.753 54.0045 33.259 111.753 0 Exp 2,1(1) 1.6584177017211914 1.6584177017211914 1.6584177017211914 1.6584177017211914 0.0 1.6584177017211914 54.0045 54.0045 33.259 33.259 111.753 111.753 DOWN 0.0 1.0 0.0 GO:0022414 2 reproductive process 343 368 17 17 14 17 14 14 82 354 2097 0.58612 0.5307 1.0 3.8 360243;360268;24950;25664;296371;304951;291234;25626;24484;24471;50549;65210;362485;50681 top2a;sult1e1;srd5a1;pparg;pltp;nuf2;mki67;krt8;igfbp3;hspb1;cyp4a1;cyp2j4;ccne2;acox1 TOP2A_10059;SULT1E1_32446;SRD5A1_32503;PPARG_32510;PLTP_32412;NUF2_33136;MKI67_9232;KRT8_8978;IGFBP3_8881;HSPB1_8847;CYP4A1_33111;CYP2J4_32580;CCNE2_8227;ACOX1_7973 25664(0.0441) 45.94169285714289 50.3641 5.73955E-13 24.859377039520094 50.1836351668023 23.721657997472544 30.80955000000004 33.30795 5.73955E-13 16.63626489652365 33.73347385408193 16.70232188909204 86.6731928571429 83.59815 5.73957E-13 61.98661441819466 91.89847640900462 54.19746507985542 54.9577;59.2729;29.2087;60.1903;87.0256;5.73955E-13;49.7822;68.9539;50.946;41.6322;23.208;16.3155;77.8893;23.8014 18.8326;45.3114;22.9308;43.9036;56.6266;5.73955E-13;35.6665;45.3374;36.3081;30.9494;18.863;8.2378;49.2672;19.0993 218.525;91.5578;39.9852;101.057;104.563;5.73957E-13;82.1147;143.578;85.0816;63.3196;29.9853;36.8422;185.461;31.3543 8 6 8 360268;25664;296371;25626;24471;50549;65210;50681 SULT1E1_32446;PPARG_32510;PLTP_32412;KRT8_8978;HSPB1_8847;CYP4A1_33111;CYP2J4_32580;ACOX1_7973 47.549974999999996 50.45255 25.300470950204534 33.5410625 37.4265 16.856539548702287 75.28215 77.4387 41.49547989745388 59.2729;60.1903;87.0256;68.9539;41.6322;23.208;16.3155;23.8014 45.3114;43.9036;56.6266;45.3374;30.9494;18.863;8.2378;19.0993 91.5578;101.057;104.563;143.578;63.3196;29.9853;36.8422;31.3543 6 360243;24950;304951;291234;24484;362485 TOP2A_10059;SRD5A1_32503;NUF2_33136;MKI67_9232;IGFBP3_8881;CCNE2_8227 43.79731666666677 50.3641 26.475545958896806 27.167533333333427 29.298650000000002 17.144524202166146 101.8612500000001 83.59815 84.23205027816299 54.9577;29.2087;5.73955E-13;49.7822;50.946;77.8893 18.8326;22.9308;5.73955E-13;35.6665;36.3081;49.2672 218.525;39.9852;5.73957E-13;82.1147;85.0816;185.461 0 Exp 2,4(0.29);Exp 4,1(0.08);Hill,1(0.08);Linear,7(0.5);Poly 2,1(0.08) 1.8400825424769593 26.190434455871582 1.5084086656570435 2.9455835819244385 0.38110244668590526 1.8264771699905396 32.91955481487027 58.96383089941554 22.094941518623237 39.524158481376844 54.20261853649042 119.14376717779534 CONFLICT 0.5714285714285714 0.42857142857142855 0.0 GO:0050801 6 ion homeostasis 172 181 3 3 2 3 2 2 94 179 2272 0.027476 0.99365 0.06407 1.1 155423;502970 anxa7;angptl3 ANXA7_8051;ANGPTL3_8045 61.420249999999996 61.420249999999996 58.0729 4.733867768009694 59.38292167911659 3.7560738372473974 41.727199999999996 41.727199999999996 40.0757 2.3355736982593363 40.72203241312114 1.8531542689631262 116.2755 116.2755 105.112 15.787573103552052 109.4809566417668 12.526604711819479 64.7676;58.0729 43.3787;40.0757 127.439;105.112 2 0 2 155423;502970 ANXA7_8051;ANGPTL3_8045 61.420249999999996 61.420249999999996 4.733867768009694 41.727199999999996 41.727199999999996 2.3355736982593363 116.2755 116.2755 15.787573103552052 64.7676;58.0729 43.3787;40.0757 127.439;105.112 0 0 Linear,2(1) 1.5556150045330432 3.1114412546157837 1.5375925302505493 1.5738487243652344 0.0256370007185096 1.5557206273078918 54.85944399999999 67.981056 38.49025999999999 44.96414 94.39504 138.15596 UP 1.0 0.0 0.0 GO:0009653 3 anatomical structure morphogenesis 282 299 6 6 2 5 2 2 94 297 2154 4.9633E-4 0.99993 9.7135E-4 0.67 58868;502970 fzd1;angptl3 FZD1_8671;ANGPTL3_8045 41.65195 41.65195 25.231 23.222730197050478 47.635232587287376 21.626276997355035 26.87745 26.87745 13.6792 18.6651441495907 31.686481110116382 17.382003500427256 118.3855 118.3855 105.112 18.771563720159378 113.54905013428827 17.48110722731585 25.231;58.0729 13.6792;40.0757 131.659;105.112 2 0 2 58868;502970 FZD1_8671;ANGPTL3_8045 41.65195 41.65195 23.222730197050478 26.87745 26.87745 18.6651441495907 118.3855 118.3855 18.771563720159378 25.231;58.0729 13.6792;40.0757 131.659;105.112 0 0 Linear,1(0.5);Poly 2,1(0.5) 1.5249469626329435 3.049997925758362 1.5124053955078125 1.5375925302505493 0.01780999377524849 1.524998962879181 9.466888000000012 73.83701199999999 1.0088800000000049 52.74601999999999 92.36944 144.40156 UP 1.0 0.0 0.0 GO:0006954 5 inflammatory response 129 140 5 5 4 5 4 4 92 136 2315 0.38338 0.78511 0.81795 2.86 29142;24614;65030;25649 vnn1;orm1;ephx2;apoa2 VNN1_10157;ORM1_9400;EPHX2_33282;APOA2_33095 13.743482499999999 13.587125 3.54778 10.272121260474476 13.175267282093639 10.659168529289344 10.1805775 9.746685 1.51564 9.428075719864138 9.583386354388557 9.760779414736392 21.0117375 22.06555 8.55785 10.14707296509483 20.757389673086116 10.600441777130754 20.7328;24.2519;6.44145;3.54778 16.8296;19.7133;2.66377;1.51564 26.7838;31.358;17.3473;8.55785 4 0 4 29142;24614;65030;25649 VNN1_10157;ORM1_9400;EPHX2_33282;APOA2_33095 13.743482499999999 13.587125 10.272121260474476 10.1805775 9.746685 9.428075719864138 21.0117375 22.06555 10.14707296509483 20.7328;24.2519;6.44145;3.54778 16.8296;19.7133;2.66377;1.51564 26.7838;31.358;17.3473;8.55785 0 0 Exp 2,1(0.25);Exp 4,1(0.25);Hill,1(0.25);Linear,1(0.25) 2.868499922012125 12.29366385936737 1.7262524366378784 4.608505725860596 1.2809231585921848 2.9794528484344482 3.676803664735017 23.810161335264986 0.9410632945331443 19.420091705466856 11.06760599420707 30.955869005792934 UP 1.0 0.0 0.0 GO:0009895 6 negative regulation of catabolic process 80 83 3 2 3 3 2 2 94 81 2370 0.38645 0.82952 0.76882 2.41 25427;25649 cyp51;apoa2 CYP51_8429;APOA2_33095 39.34999 39.34999 3.54778 50.63197094492965 19.142664719480518 41.79622580787357 24.80682 24.80682 1.51564 32.93870263967298 11.660915028571429 27.19059573729746 89.968425 89.968425 8.55785 115.13193928559203 44.01902773376623 95.04035577269745 75.1522;3.54778 48.098;1.51564 171.379;8.55785 1 1 1 25649 APOA2_33095 3.54778 3.54778 1.51564 1.51564 8.55785 8.55785 3.54778 1.51564 8.55785 1 25427 CYP51_8429 75.1522 75.1522 48.098 48.098 171.379 171.379 75.1522 48.098 171.379 0 Hill,1(0.5);Linear,1(0.5) 1.6792994117412035 3.3598759174346924 1.633623480796814 1.7262524366378784 0.06549856280944594 1.6799379587173462 -30.82234159999998 109.52232159999997 -20.843892799999995 70.4575328 -69.59630199999998 249.53315199999997 CONFLICT 0.5 0.5 0.0 GO:0044271 5 cellular nitrogen compound biosynthetic process 201 229 9 9 7 9 7 7 89 222 2229 0.35511 0.77533 0.7156 3.06 78968;298490;313245;362094;364975;25612;65155 srebf1;ppcs;polr1e;mrps2;gcdh;asns;alas1 SREBF1_32750;PPCS_9540;POLR1E_9523;MRPS2_9250;GCDH_8693;ASNS_8091;ALAS1_8018 37.840500000000006 28.1893 15.1091 22.98985798455483 39.40261278354643 20.62340408373329 26.782929999999997 23.1774 7.94061 15.614418049502628 28.506262050401894 14.813512360955224 67.36659999999999 36.6615 30.6311 52.01571906372792 66.07618213621672 41.47628455459684 41.2009;15.1091;73.982;63.3158;15.9021;28.1893;27.1843 31.4864;7.94061;47.589;45.3429;10.4227;23.1774;21.5215 60.0774;30.6311;165.722;111.245;31.2818;35.9474;36.6615 7 0 7 78968;298490;313245;362094;364975;25612;65155 SREBF1_32750;PPCS_9540;POLR1E_9523;MRPS2_9250;GCDH_8693;ASNS_8091;ALAS1_8018 37.840500000000006 28.1893 22.98985798455483 26.782929999999997 23.1774 15.614418049502628 67.36659999999999 36.6615 52.01571906372792 41.2009;15.1091;73.982;63.3158;15.9021;28.1893;27.1843 31.4864;7.94061;47.589;45.3429;10.4227;23.1774;21.5215 60.0774;30.6311;165.722;111.245;31.2818;35.9474;36.6615 0 0 Exp 2,3(0.43);Hill,1(0.15);Linear,2(0.29);Poly 2,1(0.15) 1.864280565297566 13.507332563400269 1.5184675455093384 3.2609751224517822 0.613611506947966 1.8392632007598877 20.809374866929083 54.87162513307093 15.215607232724986 38.350252767275 28.83281606552886 105.90038393447115 UP 1.0 0.0 0.0 GO:0051962 6 positive regulation of nervous system development 142 153 5 5 4 5 4 4 92 149 2302 0.30473 0.84042 0.65885 2.61 25664;24471;58868;64515 pparg;hspb1;fzd1;cdc20 PPARG_32510;HSPB1_8847;FZD1_8671;CDC20_8255 25664(0.0441) 57.155625 50.911249999999995 25.231 32.873066667448285 57.54403376063004 29.845723424727392 35.020525 37.4265 13.6792 16.574633941332362 36.51990373256252 15.264877679693834 187.3014 116.358 63.3196 179.4359425220414 170.9932562523564 168.85992074876398 60.1903;41.6322;25.231;101.569 43.9036;30.9494;13.6792;51.5499 101.057;63.3196;131.659;453.17 3 1 3 25664;24471;58868 PPARG_32510;HSPB1_8847;FZD1_8671 42.35116666666667 41.6322 17.490736088665123 29.51073333333333 30.9494 15.163472892887478 98.67853333333333 101.057 34.23172835036719 60.1903;41.6322;25.231 43.9036;30.9494;13.6792 101.057;63.3196;131.659 1 64515 CDC20_8255 101.569 101.569 51.5499 51.5499 453.17 453.17 101.569 51.5499 453.17 0 Exp 2,2(0.5);Linear,1(0.25);Poly 2,1(0.25) 1.5973341415261115 6.412574887275696 1.5124053955078125 1.8468482494354248 0.16262333538432994 1.5266606211662292 24.940019665900678 89.37123033409932 18.77738373749429 51.26366626250571 11.454176328399456 363.14862367160055 UP 0.75 0.25 0.0 GO:0033273 5 response to vitamin 73 78 3 3 3 3 3 3 93 75 2376 0.66134 0.57062 1.0 3.85 25664;24614;58868 pparg;orm1;fzd1 PPARG_32510;ORM1_9400;FZD1_8671 25664(0.0441) 36.55773333333334 25.231 24.2519 20.472257194636185 39.094068925879995 21.4095588476403 25.765366666666665 19.7133 13.6792 15.995287494863394 28.230349432414382 16.13851173846118 88.02466666666665 101.057 31.358 51.40480458413723 81.80303872937135 49.70262101397829 60.1903;24.2519;25.231 43.9036;19.7133;13.6792 101.057;31.358;131.659 3 0 3 25664;24614;58868 PPARG_32510;ORM1_9400;FZD1_8671 36.55773333333334 25.231 20.472257194636185 25.765366666666665 19.7133 15.995287494863394 88.02466666666665 101.057 51.40480458413723 60.1903;24.2519;25.231 43.9036;19.7133;13.6792 101.057;31.358;131.659 0 0 Exp 2,2(0.67);Poly 2,1(0.34) 2.0216717879534736 6.621347427368164 1.5124053955078125 3.5849626064300537 1.19326436181582 1.5239794254302979 13.391193456938112 59.72427320972855 7.664994926453989 43.865738406879345 29.85465424865491 146.19467908467846 UP 1.0 0.0 0.0 GO:1901575 4 organic substance catabolic process 296 332 26 25 23 26 22 22 74 310 2141 0.99791 0.0046735 0.0076713 6.63 286954;360268;64305;24950;364975;65030;171142;291075;29740;64526;117543;114027;311849;25413;64515;25649;502970;26760;50681;681337;192272;170465 ugt2b1;sult1e1;sult1b1;srd5a1;gcdh;ephx2;ehhadh;eci2;eci1;ech1;decr1;dao;crat;cpt2;cdc20;apoa2;angptl3;akr7a3;acox1;acot4;acot2;acaa2 UGT2B10_33303,UGT2B1_33224;SULT1E1_32446;SULT1B1_32942;SRD5A1_32503;GCDH_8693;EPHX2_33282;EHHADH_8534;ECI2_8521;ECI1_8520;ECH1_8516;DECR1_8458;DAO_8437;CRAT_8375;CPT2_8374;CDC20_8255;APOA2_33095;ANGPTL3_8045;AKR7A3_8015;ACOX1_7973;ACOT4_7971;ACOT2_7969;ACAA2_7955 25.209899545454547 14.54955 3.54778 25.91843942935378 27.7486021468182 26.54503183360432 16.0868075 9.41634 1.51564 15.513351002045189 17.819393707320515 16.44349628133485 55.28924545454545 29.68235 8.55785 93.00701416532021 58.27205066671373 87.12883105979675 15.5 26.50505 12.54415;59.2729;15.4629;29.2087;15.9021;6.44145;7.29984;8.72912;11.7653;9.87438;21.6199;6.1336;8.98517;31.2175;101.569;3.54778;58.0729;18.819;23.8014;12.3157;13.6362;78.3988 7.348245;45.3114;7.69418;22.9308;10.4227;2.66377;5.26587;5.10151;8.40998;6.59127;17.4928;2.43617;1.97988;24.8356;51.5499;1.51564;40.0757;11.5469;19.0993;6.70485;11.3249;43.6084 25.495849999999997;91.5578;35.0879;39.9852;31.2818;17.3473;11.8779;17.7951;18.8402;19.44;28.0829;16.2027;31.3726;42.0237;453.17;8.55785;105.112;51.6405;31.3543;24.3993;16.9658;98.7727 20 3 19 286954;360268;64305;364975;65030;171142;291075;29740;64526;117543;114027;311849;25413;25649;502970;26760;50681;681337;192272 UGT2B10_33303,UGT2B1_33224;SULT1E1_32446;SULT1B1_32942;GCDH_8693;EPHX2_33282;EHHADH_8534;ECI2_8521;ECI1_8520;ECH1_8516;DECR1_8458;DAO_8437;CRAT_8375;CPT2_8374;APOA2_33095;ANGPTL3_8045;AKR7A3_8015;ACOX1_7973;ACOT4_7971;ACOT2_7969 18.181120526315787 12.54415 15.798457795955725 12.41161394736842 7.69418 12.32748087154452 32.86502631578948 25.495849999999997 25.460440363534605 12.54415;59.2729;15.4629;15.9021;6.44145;7.29984;8.72912;11.7653;9.87438;21.6199;6.1336;8.98517;31.2175;3.54778;58.0729;18.819;23.8014;12.3157;13.6362 7.348245;45.3114;7.69418;10.4227;2.66377;5.26587;5.10151;8.40998;6.59127;17.4928;2.43617;1.97988;24.8356;1.51564;40.0757;11.5469;19.0993;6.70485;11.3249 25.495849999999997;91.5578;35.0879;31.2818;17.3473;11.8779;17.7951;18.8402;19.44;28.0829;16.2027;31.3726;42.0237;8.55785;105.112;51.6405;31.3543;24.3993;16.9658 3 24950;64515;170465 SRD5A1_32503;CDC20_8255;ACAA2_7955 69.7255 78.3988 36.95162856614036 39.363033333333334 43.6084 14.774321466765686 197.3093 98.7727 223.52296502245582 29.2087;101.569;78.3988 22.9308;51.5499;43.6084 39.9852;453.17;98.7727 0 Exp 2,3(0.14);Exp 4,3(0.14);Hill,7(0.31);Linear,5(0.22);Poly 2,5(0.22) 2.0857243821037446 51.02711820602417 1.5293418169021606 4.473705768585205 0.8813007555032616 1.729828953742981 14.379273033265399 36.04052605764368 9.604190708444358 22.56942429155564 16.42408784410582 94.1544030649851 UP 0.8636363636363636 0.13636363636363635 0.0 GO:0033875 7 ribonucleoside bisphosphate metabolic process 38 41 11 11 10 11 10 10 86 31 2420 1.0 1.5388E-6 1.5388E-6 24.39 360268;64305;298490;364975;24763;681337;314304;192272;50559;170465 sult1e1;sult1b1;ppcs;gcdh;acsm3;acot4;acot3;acot2;acot1;acaa2 SULT1E1_32446;SULT1B1_32942;PPCS_9540;GCDH_8693;ACSM3_7976;ACOT4_7971;ACOT3_7970;ACOT2_7969;ACOT1_7968;ACAA2_7955 32.17006 22.20775 12.3157 23.23948863193374 34.413535230639866 26.21162173785536 22.470094 18.006149999999998 6.70485 16.047901589057407 23.01862792664371 17.52539991030339 47.45316999999999 34.27605 16.9658 28.927307731394198 51.828358408745096 33.02152944556171 1.5 14.37265 3.5 15.682500000000001 59.2729;15.4629;15.1091;15.9021;52.2057;12.3157;30.8838;13.6362;28.5134;78.3988 45.3114;7.69418;7.94061;10.4227;42.2655;6.70485;24.6874;11.3249;24.741;43.6084 91.5578;35.0879;30.6311;31.2818;71.1126;24.3993;41.2585;16.9658;33.4642;98.7727 9 1 9 360268;64305;298490;364975;24763;681337;314304;192272;50559 SULT1E1_32446;SULT1B1_32942;PPCS_9540;GCDH_8693;ACSM3_7976;ACOT4_7971;ACOT3_7970;ACOT2_7969;ACOT1_7968 27.033533333333335 15.9021 17.628502946577733 20.12139333333333 11.3249 15.088657887485391 41.751 33.4642 23.991601002955186 59.2729;15.4629;15.1091;15.9021;52.2057;12.3157;30.8838;13.6362;28.5134 45.3114;7.69418;7.94061;10.4227;42.2655;6.70485;24.6874;11.3249;24.741 91.5578;35.0879;30.6311;31.2818;71.1126;24.3993;41.2585;16.9658;33.4642 1 170465 ACAA2_7955 78.3988 78.3988 43.6084 43.6084 98.7727 98.7727 78.3988 43.6084 98.7727 0 Exp 2,4(0.4);Exp 4,1(0.1);Hill,2(0.2);Linear,1(0.1);Poly 2,2(0.2) 3.1549916650982 72.94439232349396 1.5464483499526978 50.888092041015625 15.342128731580774 2.4932953119277954 17.766075716037783 46.574044283962216 12.523501545219252 32.416686454780745 29.523838914470442 65.38250108552955 UP 0.9 0.1 0.0 GO:0006469 8 negative regulation of protein kinase activity 71 76 6 6 3 6 3 3 93 73 2378 0.67878 0.55267 0.76263 3.95 24679;24471;299626 prkar2b;hspb1;gadd45b PRKAR2B_33052;HSPB1_8847;GADD45B_8679 67.64999999999999 52.5718 41.6322 36.00804943398075 59.49720890701833 29.43421186652877 42.507533333333335 37.1918 30.9494 14.942805012892784 39.30857147966025 12.226861019353496 100.04886666666668 89.36 63.3196 43.07998531398696 91.78038986365668 35.510518863177836 108.746;41.6322;52.5718 59.3814;30.9494;37.1918 147.467;63.3196;89.36 3 0 3 24679;24471;299626 PRKAR2B_33052;HSPB1_8847;GADD45B_8679 67.64999999999999 52.5718 36.00804943398075 42.507533333333335 37.1918 14.942805012892784 100.04886666666668 89.36 43.07998531398696 108.746;41.6322;52.5718 59.3814;30.9494;37.1918 147.467;63.3196;89.36 0 0 Linear,2(0.67);Power,1(0.34) 1.6688818196342161 5.0204503536224365 1.5528020858764648 1.8468482494354248 0.15393974357614673 1.6208000183105469 26.903056213943835 108.39694378605617 25.598157639915545 59.41690902675113 51.29927407594428 148.79845925738906 UP 1.0 0.0 0.0 GO:0043086 5 negative regulation of catalytic activity 212 228 13 13 9 13 9 9 87 219 2232 0.64475 0.49492 0.85508 3.95 361604;84386;299270;24679;25664;24471;299626;25649;502970 sytl2;slpi;serpina6;prkar2b;pparg;hspb1;gadd45b;apoa2;angptl3 SYTL2_32351;SLPI_9890;SERPINA6_32325;PRKAR2B_33052;PPARG_32510;HSPB1_8847;GADD45B_8679;APOA2_33095;ANGPTL3_8045 25664(0.0441) 57.099764444444446 58.0729 3.54778 27.48229499150095 55.55674112561441 22.226178057625937 36.915771111111106 37.8192 1.51564 15.450545060806474 36.63809161461814 13.145378808948463 92.53021666666666 92.543 8.55785 40.38735602049548 91.8063190040243 34.864196925906356 67.0093;53.7429;68.3847;108.746;60.1903;41.6322;52.5718;3.54778;58.0729 44.4373;37.8192;36.9679;59.3814;43.9036;30.9494;37.1918;1.51564;40.0757 135.846;92.543;89.5095;147.467;101.057;63.3196;89.36;8.55785;105.112 7 2 7 299270;24679;25664;24471;299626;25649;502970 SERPINA6_32325;PRKAR2B_33052;PPARG_32510;HSPB1_8847;GADD45B_8679;APOA2_33095;ANGPTL3_8045 56.163668571428566 58.0729 31.428784422854264 35.71220571428571 37.1918 17.52248637785827 86.34042142857142 89.5095 42.631475081582025 68.3847;108.746;60.1903;41.6322;52.5718;3.54778;58.0729 36.9679;59.3814;43.9036;30.9494;37.1918;1.51564;40.0757 89.5095;147.467;101.057;63.3196;89.36;8.55785;105.112 2 361604;84386 SYTL2_32351;SLPI_9890 60.376099999999994 60.376099999999994 9.38076140193329 41.12825 41.12825 4.67970338857073 114.1945 114.1945 30.619844945721088 67.0093;53.7429 44.4373;37.8192 135.846;92.543 0 Exp 2,1(0.12);Hill,1(0.12);Linear,5(0.56);Poly 2,1(0.12);Power,1(0.12) 1.6508851913082656 14.903570055961609 1.512166976928711 1.8690931797027588 0.13881722182880263 1.6208000183105469 39.14466504999716 75.05486383889172 26.82141500471755 47.01012721750466 66.1438107332763 118.91662260005702 UP 0.7777777777777778 0.2222222222222222 0.0 GO:0080090 5 regulation of primary metabolic process 955 1029 38 37 27 37 26 26 70 1003 1448 0.0039453 0.99802 0.0077269 2.53 360243;78968;84386;299270;24679;25664;363465;54133;65035;259241;24484;63868;24471;29455;299626;58868;65030;25427;306575;64515;25599;362485;114494;25649;502970;81633 top2a;srebf1;slpi;serpina6;prkar2b;pparg;pir;pdlim1;nr1i3;nr1d2;igfbp3;hspd1;hspb1;gdf15;gadd45b;fzd1;ephx2;cyp51;ckap2;cdc20;cd74;ccne2;ccna2;apoa2;angptl3;acta2 TOP2A_10059;SREBF1_32750;SLPI_9890;SERPINA6_32325;PRKAR2B_33052;PPARG_32510;PIR_9487;PDLIM1_9452;NR1I3_32602;NR1D2_9358;IGFBP3_8881;HSPD1_8849;HSPB1_8847;GDF15_33113;GADD45B_8679;FZD1_8671;EPHX2_33282;CYP51_8429;CKAP2_8324;CDC20_8255;CD74_8252;CCNE2_8227;CCNA2_8221;APOA2_33095;ANGPTL3_8045;ACTA2_33040 25664(0.0441) 56.87653961538462 54.350300000000004 3.54778 28.32521431791829 55.62128487227497 26.081672719967976 36.057969615384614 37.574 1.51564 16.996414434319373 36.09291696574256 16.26077477413628 111.14665961538464 96.80000000000001 8.55785 85.37174816169576 104.3647841434367 76.98547711331773 54.9577;41.2009;53.7429;68.3847;108.746;60.1903;52.1607;67.1147;22.095;99.0234;50.946;34.4455;41.6322;21.3654;52.5718;25.231;6.44145;75.1522;64.2131;101.569;94.9138;77.8893;52.8265;3.54778;58.0729;90.3558 18.8326;31.4864;37.8192;36.9679;59.3814;43.9036;40.9644;47.2419;12.9529;42.5557;36.3081;26.6907;30.9494;17.8875;37.1918;13.6792;2.66377;48.098;43.1133;51.5499;58.8146;49.2672;37.3288;1.51564;40.0757;70.2676 218.525;60.0774;92.543;89.5095;147.467;101.057;74.9097;123.914;55.8619;102.838;85.0816;48.4857;63.3196;26.3528;89.36;131.659;17.3473;171.379;125.437;453.17;118.773;185.461;90.0448;8.55785;105.112;103.57 17 9 17 78968;299270;24679;25664;363465;54133;65035;259241;63868;24471;29455;299626;58868;65030;25599;25649;502970 SREBF1_32750;SERPINA6_32325;PRKAR2B_33052;PPARG_32510;PIR_9487;PDLIM1_9452;NR1I3_32602;NR1D2_9358;HSPD1_8849;HSPB1_8847;GDF15_33113;GADD45B_8679;FZD1_8671;EPHX2_33282;CD74_8252;APOA2_33095;ANGPTL3_8045 50.41985470588235 52.1607 30.960177303818476 32.05426529411765 36.9679 17.44353963458968 80.2706911764706 89.36 40.78053412474442 41.2009;68.3847;108.746;60.1903;52.1607;67.1147;22.095;99.0234;34.4455;41.6322;21.3654;52.5718;25.231;6.44145;94.9138;3.54778;58.0729 31.4864;36.9679;59.3814;43.9036;40.9644;47.2419;12.9529;42.5557;26.6907;30.9494;17.8875;37.1918;13.6792;2.66377;58.8146;1.51564;40.0757 60.0774;89.5095;147.467;101.057;74.9097;123.914;55.8619;102.838;48.4857;63.3196;26.3528;89.36;131.659;17.3473;118.773;8.55785;105.112 9 360243;84386;24484;25427;306575;64515;362485;114494;81633 TOP2A_10059;SLPI_9890;IGFBP3_8881;CYP51_8429;CKAP2_8324;CDC20_8255;CCNE2_8227;CCNA2_8221;ACTA2_33040 69.07249999999999 64.2131 18.282644048659982 43.62052222222222 43.1133 13.992344123196228 169.46793333333335 125.437 116.60868439794696 54.9577;53.7429;50.946;75.1522;64.2131;101.569;77.8893;52.8265;90.3558 18.8326;37.8192;36.3081;48.098;43.1133;51.5499;49.2672;37.3288;70.2676 218.525;92.543;85.0816;171.379;125.437;453.17;185.461;90.0448;103.57 0 Exp 2,8(0.31);Exp 4,1(0.04);Hill,1(0.04);Linear,9(0.35);Poly 2,5(0.2);Power,2(0.08) 1.871331925420766 50.66138160228729 1.5124053955078125 5.015069484710693 0.7101407645448664 1.7201437950134277 45.988677759762474 67.76440147100676 29.52475823965611 42.591180991113106 78.33081610843882 143.96250312233042 UP 0.6538461538461539 0.34615384615384615 0.0 GO:0010564 6 regulation of cell cycle process 146 156 5 5 3 5 3 3 93 153 2298 0.14863 0.94158 0.27837 1.92 308761;291234;64515 prc1;mki67;cdc20 PRC1_9556;MKI67_9232;CDC20_8255 77.21723333333334 80.3005 49.7822 26.030713850436975 79.25315481502204 24.88290187968571 45.82983333333333 50.2731 35.6665 8.824826507831931 46.68492815581509 8.357735180978345 244.74856666666665 198.961 82.1147 189.7179086445541 254.85950494440175 185.94373539463038 80.3005;49.7822;101.569 50.2731;35.6665;51.5499 198.961;82.1147;453.17 0 3 0 3 308761;291234;64515 PRC1_9556;MKI67_9232;CDC20_8255 77.21723333333334 80.3005 26.030713850436975 45.82983333333333 50.2731 8.824826507831931 244.74856666666665 198.961 189.7179086445541 80.3005;49.7822;101.569 50.2731;35.6665;51.5499 198.961;82.1147;453.17 0 Exp 2,1(0.34);Linear,2(0.67) 1.845641499627534 5.613558411598206 1.5293418169021606 2.285626173019409 0.38333289744178894 1.7985904216766357 47.760707621787375 106.67375904487928 35.843602052030235 55.81606461463643 30.06254283965552 459.4345904936778 DOWN 0.0 1.0 0.0 GO:1902531 6 regulation of intracellular signal transduction 377 399 12 12 9 12 9 9 87 390 2061 0.050134 0.97563 0.086868 2.26 29142;365813;24679;24484;24471;29455;299626;25599;81633 vnn1;trim59;prkar2b;igfbp3;hspb1;gdf15;gadd45b;cd74;acta2 VNN1_10157;TRIM59_10085;PRKAR2B_33052;IGFBP3_8881;HSPB1_8847;GDF15_33113;GADD45B_8679;CD74_8252;ACTA2_33040 59.71017777777778 52.5718 20.7328 31.70160280197902 64.800176520994 26.826827585461196 40.13965555555555 36.3081 16.8296 18.759850362683544 43.344521930162806 16.404318824943537 86.95453333333334 89.36 26.3528 41.87964364557079 96.70610871036845 31.865877840697294 20.7328;56.1278;108.746;50.946;41.6322;21.3654;52.5718;94.9138;90.3558 16.8296;33.6269;59.3814;36.3081;30.9494;17.8875;37.1918;58.8146;70.2676 26.7838;121.883;147.467;85.0816;63.3196;26.3528;89.36;118.773;103.57 6 3 6 29142;24679;24471;29455;299626;25599 VNN1_10157;PRKAR2B_33052;HSPB1_8847;GDF15_33113;GADD45B_8679;CD74_8252 56.660333333333334 47.102000000000004 37.29698446484201 36.84238333333334 34.0706 18.89674057105263 78.67603333333334 76.3398 49.235059959409696 20.7328;108.746;41.6322;21.3654;52.5718;94.9138 16.8296;59.3814;30.9494;17.8875;37.1918;58.8146 26.7838;147.467;63.3196;26.3528;89.36;118.773 3 365813;24484;81633 TRIM59_10085;IGFBP3_8881;ACTA2_33040 65.80986666666666 56.1278 21.41471212072051 46.73420000000001 36.3081 20.424565969195026 103.51153333333332 103.57 18.4007696646998 56.1278;50.946;90.3558 33.6269;36.3081;70.2676 121.883;85.0816;103.57 0 Exp 2,2(0.23);Linear,4(0.45);Poly 2,2(0.23);Power,1(0.12) 2.08893496238387 21.169204592704773 1.528815746307373 5.015069484710693 1.4014946809031659 1.6577342748641968 38.998463947151485 80.42189160840408 27.88321998526898 52.39609112584213 59.593166151560396 114.31590051510626 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0051093 5 negative regulation of developmental process 252 270 8 7 5 8 4 4 92 266 2185 0.018984 0.99401 0.040437 1.48 25664;102551184;29455;25599 pparg;loc102551184;gdf15;cd74 PPARG_32510;HIST1H4A_32934;GDF15_33113;CD74_8252 25664(0.0441) 58.69995 59.2603 21.3654 30.042577229492135 72.16579910960688 24.727813196750326 40.203125 42.0552 17.8875 16.912201212413677 48.2429907576152 12.566838003220742 88.0212 103.4795 26.3528 41.786440592134696 104.10248274928405 25.25570800413791 60.1903;58.3303;21.3654;94.9138 43.9036;40.2068;17.8875;58.8146 101.057;105.902;26.3528;118.773 3 1 3 25664;29455;25599 PPARG_32510;GDF15_33113;CD74_8252 58.82316666666666 60.1903 36.793254487790755 40.2019 43.9036 20.713131481502256 82.06093333333332 101.057 49.051108586996634 60.1903;21.3654;94.9138 43.9036;17.8875;58.8146 101.057;26.3528;118.773 1 102551184 HIST1H4A_32934 58.3303 58.3303 40.2068 40.2068 105.902 105.902 58.3303 40.2068 105.902 0 Exp 2,2(0.5);Linear,1(0.25);Poly 2,1(0.25) 2.140028220685614 9.852198719978333 1.5239794254302979 5.015069484710693 1.702494624623478 1.6565749049186707 29.258224315097703 88.1416756849023 23.629167811834595 56.77708218816541 47.07048821970802 128.97191178029198 UP 0.75 0.25 0.0 GO:0055088 6 lipid homeostasis 50 52 9 9 7 9 7 7 89 45 2406 0.99942 0.0028888 0.0028888 13.46 65035;259241;65030;25649;502970;50681;114628 nr1i3;nr1d2;ephx2;apoa2;angptl3;acox1;abcg5 NR1I3_32602;NR1D2_9358;EPHX2_33282;APOA2_33095;ANGPTL3_8045;ACOX1_7973;ABCG5_7947 35.156261428571426 23.8014 3.54778 33.49509677582797 33.742465512397644 29.647356186576733 20.438972857142858 19.0993 1.51564 16.43601828788095 20.784001600968743 16.70619938557015 53.07203571428571 50.4329 8.55785 38.57673517465671 56.198263966093876 39.10857148087898 1.5 14.268225 4.5 45.5924 22.095;99.0234;6.44145;3.54778;58.0729;23.8014;33.1119 12.9529;42.5557;2.66377;1.51564;40.0757;19.0993;24.2098 55.8619;102.838;17.3473;8.55785;105.112;31.3543;50.4329 6 1 6 65035;259241;65030;25649;502970;50681 NR1I3_32602;NR1D2_9358;EPHX2_33282;APOA2_33095;ANGPTL3_8045;ACOX1_7973 35.49698833333333 22.9482 36.67874879419985 19.810501666666667 16.0261 17.912382250233964 53.51189166666666 43.6081 42.23946283640946 22.095;99.0234;6.44145;3.54778;58.0729;23.8014 12.9529;42.5557;2.66377;1.51564;40.0757;19.0993 55.8619;102.838;17.3473;8.55785;105.112;31.3543 1 114628 ABCG5_7947 33.1119 33.1119 24.2098 24.2098 50.4329 50.4329 33.1119 24.2098 50.4329 0 Exp 2,1(0.15);Exp 4,1(0.15);Hill,1(0.15);Linear,2(0.29);Poly 2,1(0.15);Power,1(0.15) 2.0285041206600014 14.534762024879456 1.5375925302505493 2.7270524501800537 0.4805409599322303 2.064556121826172 10.342746490084423 59.96977636705843 8.263000115666925 32.61494559861879 24.493990368102665 81.65008106046875 UP 0.8571428571428571 0.14285714285714285 0.0 GO:0042886 6 amide transport 189 201 7 7 6 7 6 6 90 195 2256 0.35505 0.78322 0.6996 2.99 83500;25664;296371;63868;24471;25599 slc22a8;pparg;pltp;hspd1;hspb1;cd74 SLC22A8_9848;PPARG_32510;PLTP_32412;HSPD1_8849;HSPB1_8847;CD74_8252 25664(0.0441) 61.78298333333333 56.3404 34.4455 24.401310046095226 63.60234414721805 23.613798715986064 42.355466666666665 40.52575 26.6907 13.26323531898109 43.42437173695463 12.720600536533315 87.55675000000001 95.09960000000001 48.4857 26.692409382125835 90.88678837859969 24.917129426970906 52.4905;60.1903;87.0256;34.4455;41.6322;94.9138 37.1479;43.9036;56.6266;26.6907;30.9494;58.8146 89.1422;101.057;104.563;48.4857;63.3196;118.773 6 0 6 83500;25664;296371;63868;24471;25599 SLC22A8_9848;PPARG_32510;PLTP_32412;HSPD1_8849;HSPB1_8847;CD74_8252 61.78298333333333 56.3404 24.401310046095226 42.355466666666665 40.52575 13.26323531898109 87.55675000000001 95.09960000000001 26.692409382125835 52.4905;60.1903;87.0256;34.4455;41.6322;94.9138 37.1479;43.9036;56.6266;26.6907;30.9494;58.8146 89.1422;101.057;104.563;48.4857;63.3196;118.773 0 0 Exp 2,2(0.34);Linear,2(0.34);Poly 2,2(0.34) 1.6371131234975231 9.844808459281921 1.5084086656570435 1.8468482494354248 0.12187552999949287 1.6539189219474792 42.25786883499511 81.30809783167155 31.742668102478532 52.96826523085481 66.19837422271567 108.91512577728435 UP 1.0 0.0 0.0 GO:0051098 4 regulation of binding 106 113 4 4 2 4 2 2 94 111 2340 0.19054 0.93362 0.44169 1.77 84386;25664 slpi;pparg SLPI_9890;PPARG_32510 25664(0.0441) 56.9666 56.9666 53.7429 4.5590002610221445 56.86967830065359 4.556939296105641 40.8614 40.8614 37.8192 4.30232049945141 40.769935163398685 4.300375570497459 96.80000000000001 96.80000000000001 92.543 6.0203071350222 96.67201176470587 6.017585564265858 53.7429;60.1903 37.8192;43.9036 92.543;101.057 1 1 1 25664 PPARG_32510 60.1903 60.1903 43.9036 43.9036 101.057 101.057 60.1903 43.9036 101.057 1 84386 SLPI_9890 53.7429 53.7429 37.8192 37.8192 92.543 92.543 53.7429 37.8192 92.543 0 Exp 2,1(0.5);Linear,1(0.5) 1.6162160462726096 3.238014578819275 1.5239794254302979 1.714035153388977 0.13438969404292778 1.6190072894096375 50.648148 63.285052 34.89868800000001 46.824112 88.45628000000002 105.14372 CONFLICT 0.5 0.5 0.0 GO:0042738 6 exogenous drug catabolic process 17 20 7 7 7 7 7 7 89 13 2438 1.0 4.5065E-6 4.5065E-6 35.0 65210;25086;24303;499353;171521;29277;24894 cyp2j4;cyp2e1;cyp2d3;cyp2c24;cyp2c13;cyp2c11;cyp2a1 CYP2J4_32580;CYP2E1_8421;CYP2D3_8420;CYP2C24_32875;CYP2C13_8419;CYP2C11_32593;CYP2A1_32717 37.76993 16.3155 7.89174 36.46764257621679 40.840986593502116 36.98515888119208 23.939947142857143 8.8664 4.16797 21.802144015688544 25.782490320366545 21.664268911552877 51.14117142857143 36.8422 15.8079 36.479912192224106 54.66071837806512 36.22258351750637 0.0 7.89174 1.0 9.37187 16.3155;7.89174;12.8059;58.9435;104.635;54.426;9.37187 8.2378;4.16797;8.8664;48.1505;49.2461;43.9518;4.95906 36.8422;15.8079;22.6004;80.4167;108.327;74.8861;19.1079 7 0 7 65210;25086;24303;499353;171521;29277;24894 CYP2J4_32580;CYP2E1_8421;CYP2D3_8420;CYP2C24_32875;CYP2C13_8419;CYP2C11_32593;CYP2A1_32717 37.76993 16.3155 36.46764257621679 23.939947142857143 8.8664 21.802144015688544 51.14117142857143 36.8422 36.479912192224106 16.3155;7.89174;12.8059;58.9435;104.635;54.426;9.37187 8.2378;4.16797;8.8664;48.1505;49.2461;43.9518;4.95906 36.8422;15.8079;22.6004;80.4167;108.327;74.8861;19.1079 0 0 Exp 2,2(0.29);Exp 4,3(0.43);Poly 2,1(0.15);Power,1(0.15) 2.0884546053696194 15.090872168540955 1.5310101509094238 2.9415390491485596 0.5862816783529734 1.940477728843689 10.754322315911068 64.78553768408892 7.788692831069589 40.09120145464469 24.11647428574397 78.16586857139887 UP 1.0 0.0 0.0 GO:0031427 5 response to methotrexate 5 5 2 2 2 2 2 2 94 3 2448 0.99951 0.013053 0.013053 40.0 83500;25612 slc22a8;asns SLC22A8_9848;ASNS_8091 40.3399 40.3399 28.1893 17.18354331097053 46.32690637162328 14.95278135104916 30.16265 30.16265 23.1774 9.87863528656666 33.60451593726907 8.596194091848666 62.5448 62.5448 35.9474 37.61440380386217 75.65022716150753 32.731314231922354 0.0 28.1893 0.0 28.1893 52.4905;28.1893 37.1479;23.1774 89.1422;35.9474 2 0 2 83500;25612 SLC22A8_9848;ASNS_8091 40.3399 40.3399 17.18354331097053 30.16265 30.16265 9.87863528656666 62.5448 62.5448 37.61440380386217 52.4905;28.1893 37.1479;23.1774 89.1422;35.9474 0 0 Exp 2,1(0.5);Linear,1(0.5) 2.3210674002471263 4.91304349899292 1.6520683765411377 3.2609751224517822 1.1376688703301983 2.45652174949646 16.524724000000006 64.155076 16.47156 43.85374 10.413896000000001 114.675704 UP 1.0 0.0 0.0 GO:0009266 4 response to temperature stimulus 80 87 5 5 3 5 3 3 93 84 2367 0.58284 0.64579 1.0 3.45 25664;291234;63868 pparg;mki67;hspd1 PPARG_32510;MKI67_9232;HSPD1_8849 25664(0.0441) 48.13933333333333 49.7822 34.4455 12.950789162183645 50.03809858653312 13.596722142694322 35.42026666666666 35.6665 26.6907 8.609091400567973 36.83517314969394 9.121702865475724 77.21913333333333 82.1147 48.4857 26.625369962938233 80.83355402893712 27.775125492891373 60.1903;49.7822;34.4455 43.9036;35.6665;26.6907 101.057;82.1147;48.4857 2 1 2 25664;63868 PPARG_32510;HSPD1_8849 47.3179 47.3179 18.204322660291428 35.29715 35.29715 12.171358313885893 74.77135 74.77135 37.173522725792346 60.1903;34.4455 43.9036;26.6907 101.057;48.4857 1 291234 MKI67_9232 49.7822 49.7822 35.6665 35.6665 82.1147 82.1147 49.7822 35.6665 82.1147 0 Exp 2,2(0.67);Linear,1(0.34) 1.7933348631414208 5.465375065803528 1.5239794254302979 2.285626173019409 0.4070613903199334 1.6557694673538208 33.484135779683896 62.79453088698277 25.67816264097849 45.16237069235484 47.08969088319684 107.34857578346983 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0050709 7 negative regulation of protein secretion 32 34 4 4 3 4 3 3 93 31 2420 0.96303 0.13427 0.13427 8.82 78968;25427;25649 srebf1;cyp51;apoa2 SREBF1_32750;CYP51_8429;APOA2_33095 39.96696 41.2009 3.54778 35.81815457036836 30.955489717698157 28.108498064769478 27.03334666666667 31.4864 1.51564 23.608289408267872 22.278037454457714 20.104649844299715 80.00475 60.0774 8.55785 83.21962617284157 52.61875200567017 56.945351503654194 0.5 22.37434 41.2009;75.1522;3.54778 31.4864;48.098;1.51564 60.0774;171.379;8.55785 2 1 2 78968;25649 SREBF1_32750;APOA2_33095 22.37434 22.37434 26.624776484830814 16.50102 16.50102 21.19252763331453 34.317625 34.317625 36.42982316867939 41.2009;3.54778 31.4864;1.51564 60.0774;8.55785 1 25427 CYP51_8429 75.1522 75.1522 48.098 48.098 171.379 171.379 75.1522 48.098 171.379 0 Exp 2,1(0.34);Hill,1(0.34);Linear,1(0.34) 1.7537059258453787 5.272431373596191 1.633623480796814 1.912555456161499 0.14206335759363947 1.7262524366378784 -0.5650975188324807 80.49901751883249 0.3180522665253669 53.74864106680796 -14.167122202590207 174.1766222025902 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0080135 5 regulation of cellular response to stress 165 174 5 5 5 5 5 5 91 169 2282 0.34844 0.7979 0.68031 2.87 29142;24471;299626;58868;25599 vnn1;hspb1;gadd45b;fzd1;cd74 VNN1_10157;HSPB1_8847;GADD45B_8679;FZD1_8671;CD74_8252 47.01631999999999 41.6322 20.7328 29.662452223509785 55.223095453007645 29.609151531445864 31.492920000000005 30.9494 13.6792 18.107929333084986 36.605319615670886 17.802911182223752 85.97908 89.36 26.7838 42.40005928170385 94.0058241085324 34.144000261307355 20.7328;41.6322;52.5718;25.231;94.9138 16.8296;30.9494;37.1918;13.6792;58.8146 26.7838;63.3196;89.36;131.659;118.773 5 0 5 29142;24471;299626;58868;25599 VNN1_10157;HSPB1_8847;GADD45B_8679;FZD1_8671;CD74_8252 47.01631999999999 41.6322 29.662452223509785 31.492920000000005 30.9494 18.107929333084986 85.97908 89.36 42.40005928170385 20.7328;41.6322;52.5718;25.231;94.9138 16.8296;30.9494;37.1918;13.6792;58.8146 26.7838;63.3196;89.36;131.659;118.773 0 0 Linear,3(0.6);Poly 2,2(0.4) 2.0139937424338687 11.178295731544495 1.5124053955078125 4.608505725860596 1.3327567026357794 1.6577342748641968 21.016034255965806 73.0166057440342 15.620620119148128 47.36521988085187 48.81378939686701 123.14437060313298 UP 1.0 0.0 0.0 GO:2001014 6 regulation of skeletal muscle cell differentiation 9 9 1 1 1 1 1 1 95 8 2443 0.95741 0.29272 0.29272 11.11 259241 nr1d2 NR1D2_9358 99.0234 99.0234 99.0234 99.0234 42.5557 42.5557 42.5557 42.5557 102.838 102.838 102.838 102.838 0.0 99.0234 0.0 99.0234 99.0234 42.5557 102.838 1 0 1 259241 NR1D2_9358 99.0234 99.0234 42.5557 42.5557 102.838 102.838 99.0234 42.5557 102.838 0 0 Power,1(1) 2.7270524501800537 2.7270524501800537 2.7270524501800537 2.7270524501800537 0.0 2.7270524501800537 99.0234 99.0234 42.5557 42.5557 102.838 102.838 UP 1.0 0.0 0.0 GO:1901880 8 negative regulation of protein depolymerization 12 13 2 2 2 2 2 2 94 11 2440 0.98873 0.083726 0.083726 15.38 64159;306575 sptan1;ckap2 SPTAN1_9932;CKAP2_8324 55.8825 55.8825 47.5519 11.781247502705265 60.10157326088976 10.158574425503282 38.764250000000004 38.764250000000004 34.4152 6.15048549343863 40.96684771988484 5.303357273814014 101.03835000000001 101.03835000000001 76.6397 34.50490173359428 113.39516605368256 29.752419022256014 0.0 47.5519 0.5 55.8825 47.5519;64.2131 34.4152;43.1133 76.6397;125.437 1 1 1 64159 SPTAN1_9932 47.5519 47.5519 34.4152 34.4152 76.6397 76.6397 47.5519 34.4152 76.6397 1 306575 CKAP2_8324 64.2131 64.2131 43.1133 43.1133 125.437 125.437 64.2131 43.1133 125.437 0 Linear,2(1) 1.9918814117688965 4.140344858169556 1.5062377452850342 2.6341071128845215 0.7975240781221804 2.070172429084778 39.55452400000001 72.210476 30.240112 47.28838800000001 53.216996000000016 148.859704 CONFLICT 0.5 0.5 0.0 GO:0030950 6 establishment or maintenance of actin cytoskeleton polarity 2 2 1 1 1 1 1 1 95 1 2450 0.99859 0.073976 0.073976 50.0 54133 pdlim1 PDLIM1_9452 67.1147 67.1147 67.1147 67.1147 47.2419 47.2419 47.2419 47.2419 123.914 123.914 123.914 123.914 0.0 67.1147 0.0 67.1147 67.1147 47.2419 123.914 1 0 1 54133 PDLIM1_9452 67.1147 67.1147 47.2419 47.2419 123.914 123.914 67.1147 47.2419 123.914 0 0 Exp 2,1(1) 1.63596773147583 1.63596773147583 1.63596773147583 1.63596773147583 0.0 1.63596773147583 67.1147 67.1147 47.2419 47.2419 123.914 123.914 UP 1.0 0.0 0.0 GO:0061870 9 positive regulation of hepatic stellate cell migration 1 1 1 1 1 1 1 1 95 0 2451 1.0 0.037691 0.037691 100.0 81633 acta2 ACTA2_33040 90.3558 90.3558 90.3558 90.3558 70.2676 70.2676 70.2676 70.2676 103.57 103.57 103.57 103.57 0.0 90.3558 0.0 90.3558 90.3558 70.2676 103.57 0 1 0 1 81633 ACTA2_33040 90.3558 90.3558 70.2676 70.2676 103.57 103.57 90.3558 70.2676 103.57 0 Poly 2,1(1) 1.600624918937683 1.600624918937683 1.600624918937683 1.600624918937683 0.0 1.600624918937683 90.3558 90.3558 70.2676 70.2676 103.57 103.57 DOWN 0.0 1.0 0.0 GO:1902275 8 regulation of chromatin organization 37 37 2 2 2 2 2 2 94 35 2416 0.83883 0.40983 0.64869 5.41 78968;291234 srebf1;mki67 SREBF1_32750;MKI67_9232 45.491550000000004 45.491550000000004 41.2009 6.067895421396113 43.841402947598255 5.601194895368279 33.57645 33.57645 31.4864 2.955777056037786 32.77263476294448 2.728439138840118 71.09604999999999 71.09604999999999 60.0774 15.582724269042384 66.85837206799751 14.384208950590157 0.5 45.491550000000004 41.2009;49.7822 31.4864;35.6665 60.0774;82.1147 1 1 1 78968 SREBF1_32750 41.2009 41.2009 31.4864 31.4864 60.0774 60.0774 41.2009 31.4864 60.0774 1 291234 MKI67_9232 49.7822 49.7822 35.6665 35.6665 82.1147 82.1147 49.7822 35.6665 82.1147 0 Exp 2,1(0.5);Linear,1(0.5) 2.090786169830334 4.198181629180908 1.912555456161499 2.285626173019409 0.2638008337523547 2.099090814590454 37.081876 53.901224000000006 29.479952 37.672948 49.49949599999999 92.69260399999999 CONFLICT 0.5 0.5 0.0 GO:1902109 8 negative regulation of mitochondrial membrane permeability involved in apoptotic process 4 4 1 1 1 1 1 1 95 3 2448 0.99197 0.14253 0.14253 25.0 170465 acaa2 ACAA2_7955 78.3988 78.3988 78.3988 78.3988 43.6084 43.6084 43.6084 43.6084 98.7727 98.7727 98.7727 98.7727 0.0 78.3988 0.0 78.3988 78.3988 43.6084 98.7727 0 1 0 1 170465 ACAA2_7955 78.3988 78.3988 43.6084 43.6084 98.7727 98.7727 78.3988 43.6084 98.7727 0 Poly 2,1(1) 1.72868812084198 1.72868812084198 1.72868812084198 1.72868812084198 0.0 1.72868812084198 78.3988 78.3988 43.6084 43.6084 98.7727 98.7727 DOWN 0.0 1.0 0.0 GO:0031324 6 negative regulation of cellular metabolic process 513 545 18 17 14 18 13 13 83 532 1919 0.032354 0.98343 0.057217 2.39 361604;78968;84386;299270;24679;25664;65035;259241;24484;63868;24471;299626;58868 sytl2;srebf1;slpi;serpina6;prkar2b;pparg;nr1i3;nr1d2;igfbp3;hspd1;hspb1;gadd45b;fzd1 SYTL2_32351;SREBF1_32750;SLPI_9890;SERPINA6_32325;PRKAR2B_33052;PPARG_32510;NR1I3_32602;NR1D2_9358;IGFBP3_8881;HSPD1_8849;HSPB1_8847;GADD45B_8679;FZD1_8671 25664(0.0441) 55.78607692307693 52.5718 22.095 25.744605427971155 53.31400578133943 21.270062548685534 34.94796923076923 36.9679 12.9529 12.505421403827524 34.637207180823104 11.035346340928125 92.54659230769231 89.5095 48.4857 31.450899916734254 89.4108461105335 28.641508752892896 67.0093;41.2009;53.7429;68.3847;108.746;60.1903;22.095;99.0234;50.946;34.4455;41.6322;52.5718;25.231 44.4373;31.4864;37.8192;36.9679;59.3814;43.9036;12.9529;42.5557;36.3081;26.6907;30.9494;37.1918;13.6792 135.846;60.0774;92.543;89.5095;147.467;101.057;55.8619;102.838;85.0816;48.4857;63.3196;89.36;131.659 10 3 10 78968;299270;24679;25664;65035;259241;63868;24471;299626;58868 SREBF1_32750;SERPINA6_32325;PRKAR2B_33052;PPARG_32510;NR1I3_32602;NR1D2_9358;HSPD1_8849;HSPB1_8847;GADD45B_8679;FZD1_8671 55.35208 47.102000000000004 29.435374254676773 33.5759 34.22715 13.974817485669648 88.96351 89.43475000000001 33.01676282851387 41.2009;68.3847;108.746;60.1903;22.095;99.0234;34.4455;41.6322;52.5718;25.231 31.4864;36.9679;59.3814;43.9036;12.9529;42.5557;26.6907;30.9494;37.1918;13.6792 60.0774;89.5095;147.467;101.057;55.8619;102.838;48.4857;63.3196;89.36;131.659 3 361604;84386;24484 SYTL2_32351;SLPI_9890;IGFBP3_8881 57.23273333333333 53.7429 8.58146865305315 39.52153333333334 37.8192 4.32370526786146 104.4902 92.543 27.409993938707895 67.0093;53.7429;50.946 44.4373;37.8192;36.3081 135.846;92.543;85.0816 0 Exp 2,3(0.24);Linear,5(0.39);Poly 2,3(0.24);Power,2(0.16) 1.7645868137158653 23.250068068504333 1.512166976928711 2.7270524501800537 0.33094883098979844 1.714035153388977 41.79114999409294 69.78100385206089 28.14994471831856 41.74599374321989 75.4496883595252 109.64349625585939 UP 0.7692307692307693 0.23076923076923078 0.0 GO:0051240 5 positive regulation of multicellular organismal process 484 516 20 20 15 20 15 15 81 501 1950 0.15289 0.90311 0.30034 2.91 29142;361604;309607;25664;24614;63868;24471;58868;117543;65210;25413;64515;25599;25649;502970 vnn1;sytl2;rt1-ce5;pparg;orm1;hspd1;hspb1;fzd1;decr1;cyp2j4;cpt2;cdc20;cd74;apoa2;angptl3 VNN1_10157;SYTL2_32351;RT1-CE5_32445;PPARG_32510;ORM1_9400;HSPD1_8849;HSPB1_8847;FZD1_8671;DECR1_8458;CYP2J4_32580;CPT2_8374;CDC20_8255;CD74_8252;APOA2_33095;ANGPTL3_8045 25664(0.0441) 43.70466533333333 34.4455 3.54778 28.609909915582413 45.1076491497628 28.439203302662033 28.354355999999996 26.5902 1.51564 16.463161379530625 29.441843141869793 16.95167234363001 98.59298333333335 63.3196 8.55785 108.43325723462611 94.91733754856455 97.09407042972647 20.7328;67.0093;54.8206;60.1903;24.2519;34.4455;41.6322;25.231;21.6199;16.3155;31.2175;101.569;94.9138;3.54778;58.0729 16.8296;44.4373;26.5902;43.9036;19.7133;26.6907;30.9494;13.6792;17.4928;8.2378;24.8356;51.5499;58.8146;1.51564;40.0757 26.7838;135.846;147.824;101.057;31.358;48.4857;63.3196;131.659;28.0829;36.8422;42.0237;453.17;118.773;8.55785;105.112 12 3 12 29142;25664;24614;63868;24471;58868;117543;65210;25413;25599;25649;502970 VNN1_10157;PPARG_32510;ORM1_9400;HSPD1_8849;HSPB1_8847;FZD1_8671;DECR1_8458;CYP2J4_32580;CPT2_8374;CD74_8252;APOA2_33095;ANGPTL3_8045 36.01425666666666 28.22425 24.743626145090136 25.228161666666665 22.27445 16.173535816393983 61.837895833333334 45.2547 41.4084086284222 20.7328;60.1903;24.2519;34.4455;41.6322;25.231;21.6199;16.3155;31.2175;94.9138;3.54778;58.0729 16.8296;43.9036;19.7133;26.6907;30.9494;13.6792;17.4928;8.2378;24.8356;58.8146;1.51564;40.0757 26.7838;101.057;31.358;48.4857;63.3196;131.659;28.0829;36.8422;42.0237;118.773;8.55785;105.112 3 361604;309607;64515 SYTL2_32351;RT1-CE5_32445;CDC20_8255 74.4663 67.0093 24.249914688303548 40.85913333333334 44.4373 12.858814624347504 245.61333333333334 147.824 179.84909098834314 67.0093;54.8206;101.569 44.4373;26.5902;51.5499 135.846;147.824;453.17 0 Exp 2,6(0.4);Exp 4,1(0.07);Hill,1(0.07);Linear,5(0.34);Poly 2,2(0.14) 1.8976637444466744 30.22968327999115 1.512166976928711 4.608505725860596 0.8800827073872485 1.7262524366378784 29.22605326043277 58.18327740623389 20.022846819750633 36.68586518024937 43.71818393922172 153.46778272744496 UP 0.8 0.2 0.0 GO:0071616 7 acyl-CoA biosynthetic process 11 13 2 2 2 2 2 2 94 11 2440 0.98873 0.083726 0.083726 15.38 298490;364975 ppcs;gcdh PPCS_9540;GCDH_8693 15.505600000000001 15.505600000000001 15.1091 0.5607356774809079 15.4394105152601 0.5528674381981966 9.181655000000001 9.181655000000001 7.94061 1.7551026705153108 8.974481912764118 1.7304750815600471 30.95645 30.95645 30.6311 0.4601143825181686 30.902137896947977 0.4536580605748951 0.0 15.1091 0.5 15.505600000000001 15.1091;15.9021 7.94061;10.4227 30.6311;31.2818 2 0 2 298490;364975 PPCS_9540;GCDH_8693 15.505600000000001 15.505600000000001 0.5607356774809079 9.181655000000001 9.181655000000001 1.7551026705153108 30.95645 30.95645 0.4601143825181686 15.1091;15.9021 7.94061;10.4227 30.6311;31.2818 0 0 Hill,1(0.5);Poly 2,1(0.5) 1.7149873814777603 3.4483429193496704 1.5464483499526978 1.9018945693969727 0.25133843211616846 1.7241714596748352 14.72846 16.28274 6.749206800000001 11.6141032 30.318764 31.594136 UP 1.0 0.0 0.0 GO:0051186 4 cofactor metabolic process 111 126 12 12 11 12 11 11 85 115 2336 0.99774 0.0067749 0.0067749 8.73 29142;298490;680308;364975;65155;24763;681337;314304;192272;50559;170465 vnn1;ppcs;mthfd2;gcdh;alas1;acsm3;acot4;acot3;acot2;acot1;acaa2 VNN1_10157;PPCS_9540;MTHFD2_9261;GCDH_8693;ALAS1_8018;ACSM3_7976;ACOT4_7971;ACOT3_7970;ACOT2_7969;ACOT1_7968;ACAA2_7955 32.0273 27.1843 12.3157 21.540414487144854 33.969067830700304 25.33418853817443 23.31213272727273 21.5215 6.70485 14.746855558866836 23.372974935628392 15.636553535168108 44.64741818181818 33.4642 16.9658 26.33583528574016 46.73840777646782 30.83714950694448 5.5 27.84885 20.7328;15.1091;57.4184;15.9021;27.1843;52.2057;12.3157;30.8838;13.6362;28.5134;78.3988 16.8296;7.94061;46.387;10.4227;21.5215;42.2655;6.70485;24.6874;11.3249;24.741;43.6084 26.7838;30.6311;79.7903;31.2818;36.6615;71.1126;24.3993;41.2585;16.9658;33.4642;98.7727 10 1 10 29142;298490;680308;364975;65155;24763;681337;314304;192272;50559 VNN1_10157;PPCS_9540;MTHFD2_9261;GCDH_8693;ALAS1_8018;ACSM3_7976;ACOT4_7971;ACOT3_7970;ACOT2_7969;ACOT1_7968 27.39015 23.958550000000002 15.89740352421321 21.282506 19.17555 13.830582766761816 39.23489 32.373 20.312178768438404 20.7328;15.1091;57.4184;15.9021;27.1843;52.2057;12.3157;30.8838;13.6362;28.5134 16.8296;7.94061;46.387;10.4227;21.5215;42.2655;6.70485;24.6874;11.3249;24.741 26.7838;30.6311;79.7903;31.2818;36.6615;71.1126;24.3993;41.2585;16.9658;33.4642 1 170465 ACAA2_7955 78.3988 78.3988 43.6084 43.6084 98.7727 98.7727 78.3988 43.6084 98.7727 0 Exp 2,4(0.37);Hill,2(0.19);Linear,3(0.28);Poly 2,2(0.19) 3.1173446623406584 76.38304579257965 1.5464483499526978 50.888092041015625 14.61459012443416 2.3701579570770264 19.297728503828488 44.756871496171506 14.597298001490632 32.02696745305482 29.083934090957403 60.21090227267895 UP 0.9090909090909091 0.09090909090909091 0.0 GO:1901566 5 organonitrogen compound biosynthetic process 169 188 11 11 9 11 9 9 87 179 2272 0.83346 0.27479 0.42474 4.79 293820;298490;25664;362094;364975;114027;25612;25649;65155 psat1;ppcs;pparg;mrps2;gcdh;dao;asns;apoa2;alas1 PSAT1_9583;PPCS_9540;PPARG_32510;MRPS2_9250;GCDH_8693;DAO_8437;ASNS_8091;APOA2_33095;ALAS1_8018 25664(0.0441) 27.322653333333335 26.3316 3.54778 21.42242317005945 34.36627538571524 24.405719760673573 19.686591111111106 20.9188 1.51564 16.253187860293327 24.7641878425415 18.170801810573774 45.20886111111111 35.2954 8.55785 35.93052873229618 57.67987777864659 41.95931787443493 26.3316;15.1091;60.1903;63.3158;15.9021;6.1336;28.1893;3.54778;27.1843 20.9188;7.94061;43.9036;45.3429;10.4227;2.43617;23.1774;1.51564;21.5215 35.2954;30.6311;101.057;111.245;31.2818;16.2027;35.9474;8.55785;36.6615 9 0 9 293820;298490;25664;362094;364975;114027;25612;25649;65155 PSAT1_9583;PPCS_9540;PPARG_32510;MRPS2_9250;GCDH_8693;DAO_8437;ASNS_8091;APOA2_33095;ALAS1_8018 27.322653333333335 26.3316 21.42242317005945 19.686591111111106 20.9188 16.253187860293327 45.20886111111111 35.2954 35.93052873229618 26.3316;15.1091;60.1903;63.3158;15.9021;6.1336;28.1893;3.54778;27.1843 20.9188;7.94061;43.9036;45.3429;10.4227;2.43617;23.1774;1.51564;21.5215 35.2954;30.6311;101.057;111.245;31.2818;16.2027;35.9474;8.55785;36.6615 0 0 Exp 2,3(0.34);Hill,3(0.34);Linear,2(0.23);Poly 2,1(0.12) 1.9368128141106054 18.011699199676514 1.5239794254302979 3.2609751224517822 0.5859964061738949 1.8392632007598877 13.326670195561158 41.31863647110551 9.067841709052809 30.305340513169412 21.734249006010945 68.6834732162113 UP 1.0 0.0 0.0 GO:0071704 3 organic substance metabolic process 1263 1393 76 74 66 75 64 64 32 1329 1122 0.99438 0.010174 0.01632 4.59 29142;286954;365813;360243;360268;64305;78968;24950;299270;293820;24679;298490;25664;313245;296371;65035;680308;362094;291234;24552;316273;315994;293502;24484;25685;63868;364975;65030;25315;171142;291075;29740;64526;117543;114027;25427;50549;266682;65210;25086;24303;499353;171521;29277;24894;311849;25413;297594;64515;25599;362485;114494;25612;25649;502970;65155;26760;24763;50681;681337;314304;192272;50559;170465 vnn1;ugt2b1;trim59;top2a;sult1e1;sult1b1;srebf1;srd5a1;serpina6;psat1;prkar2b;ppcs;pparg;polr1e;pltp;nr1i3;mthfd2;mrps2;mki67;me1;mcm3;mapkapk3;kif22;igfbp3;igfbp1;hspd1;gcdh;ephx2;ephx1;ehhadh;eci2;eci1;ech1;decr1;dao;cyp51;cyp4a1;cyp3a2;cyp2j4;cyp2e1;cyp2d3;cyp2c24;cyp2c13;cyp2c11;cyp2a1;crat;cpt2;cdca3;cdc20;cd74;ccne2;ccna2;asns;apoa2;angptl3;alas1;akr7a3;acsm3;acox1;acot4;acot3;acot2;acot1;acaa2 VNN1_10157;UGT2B10_33303,UGT2B1_33224;TRIM59_10085;TOP2A_10059;SULT1E1_32446;SULT1B1_32942;SREBF1_32750;SRD5A1_32503;SERPINA6_32325;PSAT1_9583;PRKAR2B_33052;PPCS_9540;PPARG_32510;POLR1E_9523;PLTP_32412;NR1I3_32602;MTHFD2_9261;MRPS2_9250;MKI67_9232;ME1_9215;MCM3_9207;MAPKAPK3_9194;KIF22_8963;IGFBP3_8881;IGFBP1_32306;HSPD1_8849;GCDH_8693;EPHX2_33282;EPHX1_8567;EHHADH_8534;ECI2_8521;ECI1_8520;ECH1_8516;DECR1_8458;DAO_8437;CYP51_8429;CYP4A1_33111;CYP3A2_32374;CYP2J4_32580;CYP2E1_8421;CYP2D3_8420;CYP2C24_32875;CYP2C13_8419;CYP2C11_32593;CYP2A1_32717;CRAT_8375;CPT2_8374;CDCA3_8260;CDC20_8255;CD74_8252;CCNE2_8227;CCNA2_8221;ASNS_8091;APOA2_33095;ANGPTL3_8045;ALAS1_8018;AKR7A3_8015;ACSM3_7976;ACOX1_7973;ACOT4_7971;ACOT3_7970;ACOT2_7969;ACOT1_7968;ACAA2_7955 25664(0.0441) 41.95370937500001 32.615449999999996 3.54778 29.614100841079797 43.02411596033687 29.492924400287734 27.287543828124996 24.714199999999998 1.51564 17.832233516326237 27.83024771800503 17.91221868950064 82.9602546875 50.063100000000006 8.55785 89.14880803441359 81.3108912016264 83.30309603988789 20.7328;12.54415;56.1278;54.9577;59.2729;15.4629;41.2009;29.2087;68.3847;26.3316;108.746;15.1091;60.1903;73.982;87.0256;22.095;57.4184;63.3158;49.7822;49.3339;54.0045;104.193;73.9175;50.946;98.8371;34.4455;15.9021;6.44145;34.0134;7.29984;8.72912;11.7653;9.87438;21.6199;6.1336;75.1522;23.208;23.2485;16.3155;7.89174;12.8059;58.9435;104.635;54.426;9.37187;8.98517;31.2175;46.7245;101.569;94.9138;77.8893;52.8265;28.1893;3.54778;58.0729;27.1843;18.819;52.2057;23.8014;12.3157;30.8838;13.6362;28.5134;78.3988 16.8296;7.348245;33.6269;18.8326;45.3114;7.69418;31.4864;22.9308;36.9679;20.9188;59.3814;7.94061;43.9036;47.589;56.6266;12.9529;46.387;45.3429;35.6665;35.4173;33.259;59.1667;47.5608;36.3081;57.328;26.6907;10.4227;2.66377;26.1579;5.26587;5.10151;8.40998;6.59127;17.4928;2.43617;48.098;18.863;18.6955;8.2378;4.16797;8.8664;48.1505;49.2461;43.9518;4.95906;1.97988;24.8356;21.1123;51.5499;58.8146;49.2672;37.3288;23.1774;1.51564;40.0757;21.5215;11.5469;42.2655;19.0993;6.70485;24.6874;11.3249;24.741;43.6084 26.7838;25.495849999999997;121.883;218.525;91.5578;35.0879;60.0774;39.9852;89.5095;35.2954;147.467;30.6311;101.057;165.722;104.563;55.8619;79.7903;111.245;82.1147;80.9924;111.753;434.985;165.416;85.0816;357.409;48.4857;31.2818;17.3473;48.3681;11.8779;17.7951;18.8402;19.44;28.0829;16.2027;171.379;29.9853;30.5145;36.8422;15.8079;22.6004;80.4167;108.327;74.8861;19.1079;31.3726;42.0237;127.486;453.17;118.773;185.461;90.0448;35.9474;8.55785;105.112;36.6615;51.6405;71.1126;31.3543;24.3993;41.2585;16.9658;33.4642;98.7727 51 14 50 29142;286954;360268;64305;78968;299270;293820;24679;298490;25664;313245;296371;65035;680308;362094;24552;25685;63868;364975;65030;25315;171142;291075;29740;64526;117543;114027;50549;266682;65210;25086;24303;499353;171521;29277;24894;311849;25413;25599;25612;25649;502970;65155;26760;24763;50681;681337;314304;192272;50559 VNN1_10157;UGT2B10_33303,UGT2B1_33224;SULT1E1_32446;SULT1B1_32942;SREBF1_32750;SERPINA6_32325;PSAT1_9583;PRKAR2B_33052;PPCS_9540;PPARG_32510;POLR1E_9523;PLTP_32412;NR1I3_32602;MTHFD2_9261;MRPS2_9250;ME1_9215;IGFBP1_32306;HSPD1_8849;GCDH_8693;EPHX2_33282;EPHX1_8567;EHHADH_8534;ECI2_8521;ECI1_8520;ECH1_8516;DECR1_8458;DAO_8437;CYP4A1_33111;CYP3A2_32374;CYP2J4_32580;CYP2E1_8421;CYP2D3_8420;CYP2C24_32875;CYP2C13_8419;CYP2C11_32593;CYP2A1_32717;CRAT_8375;CPT2_8374;CD74_8252;ASNS_8091;APOA2_33095;ANGPTL3_8045;ALAS1_8018;AKR7A3_8015;ACSM3_7976;ACOX1_7973;ACOT4_7971;ACOT3_7970;ACOT2_7969;ACOT1_7968 35.586794000000005 25.0665 28.60421878177591 24.161736099999995 20.009050000000002 18.007592566235505 58.46798600000001 36.30445 57.096950121664285 20.7328;12.54415;59.2729;15.4629;41.2009;68.3847;26.3316;108.746;15.1091;60.1903;73.982;87.0256;22.095;57.4184;63.3158;49.3339;98.8371;34.4455;15.9021;6.44145;34.0134;7.29984;8.72912;11.7653;9.87438;21.6199;6.1336;23.208;23.2485;16.3155;7.89174;12.8059;58.9435;104.635;54.426;9.37187;8.98517;31.2175;94.9138;28.1893;3.54778;58.0729;27.1843;18.819;52.2057;23.8014;12.3157;30.8838;13.6362;28.5134 16.8296;7.348245;45.3114;7.69418;31.4864;36.9679;20.9188;59.3814;7.94061;43.9036;47.589;56.6266;12.9529;46.387;45.3429;35.4173;57.328;26.6907;10.4227;2.66377;26.1579;5.26587;5.10151;8.40998;6.59127;17.4928;2.43617;18.863;18.6955;8.2378;4.16797;8.8664;48.1505;49.2461;43.9518;4.95906;1.97988;24.8356;58.8146;23.1774;1.51564;40.0757;21.5215;11.5469;42.2655;19.0993;6.70485;24.6874;11.3249;24.741 26.7838;25.495849999999997;91.5578;35.0879;60.0774;89.5095;35.2954;147.467;30.6311;101.057;165.722;104.563;55.8619;79.7903;111.245;80.9924;357.409;48.4857;31.2818;17.3473;48.3681;11.8779;17.7951;18.8402;19.44;28.0829;16.2027;29.9853;30.5145;36.8422;15.8079;22.6004;80.4167;108.327;74.8861;19.1079;31.3726;42.0237;118.773;35.9474;8.55785;105.112;36.6615;51.6405;71.1126;31.3543;24.3993;41.2585;16.9658;33.4642 14 365813;360243;24950;291234;316273;315994;293502;24484;25427;297594;64515;362485;114494;170465 TRIM59_10085;TOP2A_10059;SRD5A1_32503;MKI67_9232;MCM3_9207;MAPKAPK3_9194;KIF22_8963;IGFBP3_8881;CYP51_8429;CDCA3_8260;CDC20_8255;CCNE2_8227;CCNA2_8221;ACAA2_7955 64.69269285714286 55.54275 21.29116465887867 38.45114285714286 36.81845 12.123041546049935 170.43264285714287 124.6845 125.21878743599578 56.1278;54.9577;29.2087;49.7822;54.0045;104.193;73.9175;50.946;75.1522;46.7245;101.569;77.8893;52.8265;78.3988 33.6269;18.8326;22.9308;35.6665;33.259;59.1667;47.5608;36.3081;48.098;21.1123;51.5499;49.2672;37.3288;43.6084 121.883;218.525;39.9852;82.1147;111.753;434.985;165.416;85.0816;171.379;127.486;453.17;185.461;90.0448;98.7727 0 Exp 2,19(0.3);Exp 4,6(0.1);Hill,8(0.13);Linear,20(0.31);Poly 2,10(0.16);Power,2(0.04) 2.1265885691617172 186.70511853694916 1.5084086656570435 50.888092041015625 6.093382493800974 1.8690931797027588 34.698254668935434 49.20916408106454 22.918646616625065 31.65644103962492 61.11879671906868 104.80171265593134 UP 0.78125 0.21875 0.0 GO:0032760 8 positive regulation of tumor necrosis factor production 43 45 4 4 4 4 4 4 92 41 2410 0.97462 0.08707 0.08707 8.89 24614;63868;24471;65210 orm1;hspd1;hspb1;cyp2j4 ORM1_9400;HSPD1_8849;HSPB1_8847;CYP2J4_32580 29.161275 29.3487 16.3155 11.143950562936224 27.247868146594623 11.164806551542188 21.3978 23.201999999999998 8.2378 9.920870143624835 19.682869916820703 10.183284273103535 45.001375 42.66395 31.358 14.146986792570571 43.01670568391867 13.680157502405224 1.5 29.3487 24.2519;34.4455;41.6322;16.3155 19.7133;26.6907;30.9494;8.2378 31.358;48.4857;63.3196;36.8422 4 0 4 24614;63868;24471;65210 ORM1_9400;HSPD1_8849;HSPB1_8847;CYP2J4_32580 29.161275 29.3487 11.143950562936224 21.3978 23.201999999999998 9.920870143624835 45.001375 42.66395 14.146986792570571 24.2519;34.4455;41.6322;16.3155 19.7133;26.6907;30.9494;8.2378 31.358;48.4857;63.3196;36.8422 0 0 Exp 2,2(0.5);Exp 4,1(0.25);Linear,1(0.25) 2.1476133435761042 9.028058052062988 1.6557694673538208 3.5849626064300537 0.8931915888634298 1.8936629891395569 18.240203448322497 40.082346551677496 11.675347259247662 31.12025274075234 31.137327943280816 58.865422056719176 UP 1.0 0.0 0.0 GO:0051046 6 regulation of secretion 220 238 13 13 11 13 11 11 85 227 2224 0.8197 0.28163 0.47264 4.62 361604;78968;309607;25664;24614;24484;63868;25427;65210;25599;25649 sytl2;srebf1;rt1-ce5;pparg;orm1;igfbp3;hspd1;cyp51;cyp2j4;cd74;apoa2 SYTL2_32351;SREBF1_32750;RT1-CE5_32445;PPARG_32510;ORM1_9400;IGFBP3_8881;HSPD1_8849;CYP51_8429;CYP2J4_32580;CD74_8252;APOA2_33095 25664(0.0441) 47.52670727272727 50.946 3.54778 26.971597687207584 45.824259077153556 27.246088369901216 31.43596727272727 31.4864 1.51564 17.298064928649733 30.501433768062643 17.594888860077294 85.93470454545455 85.0816 8.55785 53.26988983263648 78.92230702689821 48.15861763636444 67.0093;41.2009;54.8206;60.1903;24.2519;50.946;34.4455;75.1522;16.3155;94.9138;3.54778 44.4373;31.4864;26.5902;43.9036;19.7133;36.3081;26.6907;48.098;8.2378;58.8146;1.51564 135.846;60.0774;147.824;101.057;31.358;85.0816;48.4857;171.379;36.8422;118.773;8.55785 7 4 7 78968;25664;24614;63868;65210;25599;25649 SREBF1_32750;PPARG_32510;ORM1_9400;HSPD1_8849;CYP2J4_32580;CD74_8252;APOA2_33095 39.26652571428571 34.4455 30.52164510825001 27.19457714285714 26.6907 19.884783319823324 57.87873571428572 48.4857 39.25126791906126 41.2009;60.1903;24.2519;34.4455;16.3155;94.9138;3.54778 31.4864;43.9036;19.7133;26.6907;8.2378;58.8146;1.51564 60.0774;101.057;31.358;48.4857;36.8422;118.773;8.55785 4 361604;309607;24484;25427 SYTL2_32351;RT1-CE5_32445;IGFBP3_8881;CYP51_8429 61.98202499999999 60.91495 11.13263759234532 38.8584 40.3727 9.548247565216693 135.03265 141.835 36.42547060995464 67.0093;54.8206;50.946;75.1522 44.4373;26.5902;36.3081;48.098 135.846;147.824;85.0816;171.379 0 Exp 2,5(0.46);Exp 4,1(0.1);Hill,1(0.1);Linear,3(0.28);Poly 2,1(0.1) 1.8281010036574221 20.73306667804718 1.512166976928711 3.5849626064300537 0.5812614048819632 1.7262524366378784 31.58751161192957 63.46590293352497 21.213464154875226 41.658470390579325 54.45421137191731 117.41519771899176 UP 0.6363636363636364 0.36363636363636365 0.0 GO:0009968 6 negative regulation of signal transduction 284 297 12 12 9 12 9 9 87 288 2163 0.30107 0.80645 0.62583 3.03 29142;365813;25664;24471;29455;58868;65210;25599;170465 vnn1;trim59;pparg;hspb1;gdf15;fzd1;cyp2j4;cd74;acaa2 VNN1_10157;TRIM59_10085;PPARG_32510;HSPB1_8847;GDF15_33113;FZD1_8671;CYP2J4_32580;CD74_8252;ACAA2_7955 25664(0.0441) 46.10084444444444 41.6322 16.3155 28.11356652819557 52.28503042182699 28.705191648005073 29.72633333333333 30.9494 8.2378 16.89043920957949 32.98898930812925 17.944743746342137 80.60478888888889 98.7727 26.3528 42.67540354549807 89.00187572585902 37.545630950140094 20.7328;56.1278;60.1903;41.6322;21.3654;25.231;16.3155;94.9138;78.3988 16.8296;33.6269;43.9036;30.9494;17.8875;13.6792;8.2378;58.8146;43.6084 26.7838;121.883;101.057;63.3196;26.3528;131.659;36.8422;118.773;98.7727 7 2 7 29142;25664;24471;29455;58868;65210;25599 VNN1_10157;PPARG_32510;HSPB1_8847;GDF15_33113;FZD1_8671;CYP2J4_32580;CD74_8252 40.054428571428566 25.231 28.645445241010215 27.18595714285714 17.8875 18.390190863415672 72.11248571428573 63.3196 44.77857066169888 20.7328;60.1903;41.6322;21.3654;25.231;16.3155;94.9138 16.8296;43.9036;30.9494;17.8875;13.6792;8.2378;58.8146 26.7838;101.057;63.3196;26.3528;131.659;36.8422;118.773 2 365813;170465 TRIM59_10085;ACAA2_7955 67.2633 67.2633 15.747975123805535 38.61765 38.61765 7.057986336413573 110.32785 110.32785 16.341449845255504 56.1278;78.3988 33.6269;43.6084 121.883;98.7727 0 Exp 2,3(0.34);Exp 4,1(0.12);Linear,2(0.23);Poly 2,3(0.34) 2.1120895738429 21.362524151802063 1.5124053955078125 5.015069484710693 1.393860364242641 1.72868812084198 27.73331431269002 64.46837457619887 18.691246383074738 40.76142028359193 52.72352523916348 108.4860525386143 UP 0.7777777777777778 0.2222222222222222 0.0 GO:0043207 4 response to external biotic stimulus 357 390 19 18 16 17 14 14 82 376 2075 0.48943 0.62497 1.0 3.59 29142;286954;365813;84386;24614;315994;25211;25626;24484;63868;24471;25086;81633;140668 vnn1;ugt2b1;trim59;slpi;orm1;mapkapk3;lyz2;krt8;igfbp3;hspd1;hspb1;cyp2e1;acta2;abcc3 VNN1_10157;UGT2B10_33303,UGT2B1_33224;TRIM59_10085;SLPI_9890;ORM1_9400;MAPKAPK3_9194;LYZ2_32611;KRT8_8978;IGFBP3_8881;HSPD1_8849;HSPB1_8847;CYP2E1_8421;ACTA2_33040;ABCC3_7941 48.458635 46.2891 7.89174 29.032411032850533 52.41398058477504 28.484396659063698 33.15154392857143 32.28815 4.16797 18.678126714522595 35.31737430329716 17.8273064256531 101.98435357142857 74.2006 15.8079 107.88440289145039 115.00514653122076 112.1403616141684 20.7328;12.54415;56.1278;53.7429;24.2519;104.193;77.8257;68.9539;50.946;34.4455;41.6322;7.89174;90.3558;34.7775 16.8296;7.348245;33.6269;37.8192;19.7133;59.1667;49.2403;45.3374;36.3081;26.6907;30.9494;4.16797;70.2676;26.6562 26.7838;25.495849999999997;121.883;92.543;31.358;434.985;185.119;143.578;85.0816;48.4857;63.3196;15.8079;103.57;49.7705 9 6 8 29142;286954;24614;25626;63868;24471;25086;140668 VNN1_10157;UGT2B10_33303,UGT2B1_33224;ORM1_9400;KRT8_8978;HSPD1_8849;HSPB1_8847;CYP2E1_8421;ABCC3_7941 30.653711250000004 29.3487 19.288361332542657 22.211601875 23.18475 13.270094804123065 50.574918749999995 39.92185 40.69051227852173 20.7328;12.54415;24.2519;68.9539;34.4455;41.6322;7.89174;34.7775 16.8296;7.348245;19.7133;45.3374;26.6907;30.9494;4.16797;26.6562 26.7838;25.495849999999997;31.358;143.578;48.4857;63.3196;15.8079;49.7705 6 365813;84386;315994;25211;24484;81633 TRIM59_10085;SLPI_9890;MAPKAPK3_9194;LYZ2_32611;IGFBP3_8881;ACTA2_33040 72.19853333333333 66.97675 22.07055178047588 47.73813333333333 43.52975 14.619188183297588 170.53026666666668 112.72649999999999 134.44914234470468 56.1278;53.7429;104.193;77.8257;50.946;90.3558 33.6269;37.8192;59.1667;49.2403;36.3081;70.2676 121.883;92.543;434.985;185.119;85.0816;103.57 0 Exp 2,3(0.2);Exp 4,2(0.14);Linear,8(0.54);Poly 2,2(0.14) 1.8843489540763094 30.023166298866272 1.5163835287094116 4.608505725860596 0.8816684679893592 1.714035153388977 33.25052807243085 63.666741927569134 23.367342817622394 42.93574503952046 45.47104735191977 158.49765979093738 CONFLICT 0.5714285714285714 0.42857142857142855 0.0 GO:0007169 7 transmembrane receptor protein tyrosine kinase signaling pathway 107 112 5 5 4 5 4 4 92 108 2343 0.58405 0.61788 1.0 3.57 78968;25685;24471;29455 srebf1;igfbp1;hspb1;gdf15 SREBF1_32750;IGFBP1_32306;HSPB1_8847;GDF15_33113 50.7589 41.41655 21.3654 33.4172768408798 45.11043901262916 20.311387310170968 34.412825 31.2179 17.8875 16.52019862317542 32.66827994833525 9.75463784804274 126.7897 61.698499999999996 26.3528 154.65210094423765 85.38300438576348 98.99162223600324 41.2009;98.8371;41.6322;21.3654 31.4864;57.328;30.9494;17.8875 60.0774;357.409;63.3196;26.3528 4 0 4 78968;25685;24471;29455 SREBF1_32750;IGFBP1_32306;HSPB1_8847;GDF15_33113 50.7589 41.41655 33.4172768408798 34.412825 31.2179 16.52019862317542 126.7897 61.698499999999996 154.65210094423765 41.2009;98.8371;41.6322;21.3654 31.4864;57.328;30.9494;17.8875 60.0774;357.409;63.3196;26.3528 0 0 Exp 2,2(0.5);Linear,2(0.5) 2.4493904212469686 10.806408405303955 1.8468482494354248 5.015069484710693 1.5442132655172573 1.9722453355789185 18.009968695937808 83.5078313040622 18.223030349288095 50.6026196507119 -24.769358925352904 278.3487589253529 UP 1.0 0.0 0.0 GO:0070848 5 response to growth factor 153 159 5 5 5 5 5 5 91 154 2297 0.43867 0.7277 0.8309 3.14 24950;24471;58868;114494;192272 srd5a1;hspb1;fzd1;ccna2;acot2 SRD5A1_32503;HSPB1_8847;FZD1_8671;CCNA2_8221;ACOT2_7969 32.50692 29.2087 13.6362 15.1333853349804 30.301548414839132 15.437230342189839 23.24262 22.9308 11.3249 11.083808108768391 21.851057585708144 11.126722003240529 68.39488 63.3196 16.9658 44.57826423776501 62.591534169891716 45.5216904322217 29.2087;41.6322;25.231;52.8265;13.6362 22.9308;30.9494;13.6792;37.3288;11.3249 39.9852;63.3196;131.659;90.0448;16.9658 3 2 3 24471;58868;192272 HSPB1_8847;FZD1_8671;ACOT2_7969 26.833133333333336 25.231 14.066596155905415 18.65116666666667 13.6792 10.715436970246863 70.64813333333333 63.3196 57.696733721878324 41.6322;25.231;13.6362 30.9494;13.6792;11.3249 63.3196;131.659;16.9658 2 24950;114494 SRD5A1_32503;CCNA2_8221 41.0176 41.0176 16.700306536707636 30.129800000000003 30.129800000000003 10.180923435523901 65.015 65.015 35.39748262348606 29.2087;52.8265 22.9308;37.3288 39.9852;90.0448 0 Linear,4(0.8);Poly 2,1(0.2) 2.242458220830471 12.109840631484985 1.5124053955078125 4.473705768585205 1.1830602343154735 1.9512832164764404 19.241922891223872 45.77191710877613 13.52723383473835 32.95800616526165 29.320308571400552 107.46945142859946 UP 0.6 0.4 0.0 GO:0010556 6 regulation of macromolecule biosynthetic process 567 609 18 18 13 18 13 13 83 596 1855 0.0078467 0.99647 0.014331 2.13 360243;78968;25664;363465;54133;65035;259241;24471;58868;306575;25599;114494;25649 top2a;srebf1;pparg;pir;pdlim1;nr1i3;nr1d2;hspb1;fzd1;ckap2;cd74;ccna2;apoa2 TOP2A_10059;SREBF1_32750;PPARG_32510;PIR_9487;PDLIM1_9452;NR1I3_32602;NR1D2_9358;HSPB1_8847;FZD1_8671;CKAP2_8324;CD74_8252;CCNA2_8221;APOA2_33095 25664(0.0441) 52.23900615384616 52.8265 3.54778 26.908520198315593 52.56866640969189 25.7812630805755 32.56449538461538 37.3288 1.51564 16.419155952066394 34.18710710254793 16.457954336372953 98.07494230769233 101.057 8.55785 50.464957185439765 95.63546811160433 46.96576185328972 54.9577;41.2009;60.1903;52.1607;67.1147;22.095;99.0234;41.6322;25.231;64.2131;94.9138;52.8265;3.54778 18.8326;31.4864;43.9036;40.9644;47.2419;12.9529;42.5557;30.9494;13.6792;43.1133;58.8146;37.3288;1.51564 218.525;60.0774;101.057;74.9097;123.914;55.8619;102.838;63.3196;131.659;125.437;118.773;90.0448;8.55785 10 3 10 78968;25664;363465;54133;65035;259241;24471;58868;25599;25649 SREBF1_32750;PPARG_32510;PIR_9487;PDLIM1_9452;NR1I3_32602;NR1D2_9358;HSPB1_8847;FZD1_8671;CD74_8252;APOA2_33095 50.710978 46.89645 30.757758627492056 32.40637399999999 36.2254 17.988494268037137 84.096745 87.98335 38.42056894178234 41.2009;60.1903;52.1607;67.1147;22.095;99.0234;41.6322;25.231;94.9138;3.54778 31.4864;43.9036;40.9644;47.2419;12.9529;42.5557;30.9494;13.6792;58.8146;1.51564 60.0774;101.057;74.9097;123.914;55.8619;102.838;63.3196;131.659;118.773;8.55785 3 360243;306575;114494 TOP2A_10059;CKAP2_8324;CCNA2_8221 57.332433333333334 54.9577 6.0533613549278815 33.091566666666665 37.3288 12.68281151256825 144.66893333333334 125.437 66.36407833167979 54.9577;64.2131;52.8265 18.8326;43.1133;37.3288 218.525;125.437;90.0448 0 Exp 2,5(0.39);Hill,1(0.08);Linear,3(0.24);Poly 2,3(0.24);Power,1(0.08) 1.9069808415225842 25.230899810791016 1.5124053955078125 2.7270524501800537 0.3951012757283458 1.8468482494354248 37.61136794839267 66.86664435929964 23.6389405367208 41.49005023250997 70.64187908749629 125.5080055278883 UP 0.7692307692307693 0.23076923076923078 0.0 GO:0031100 5 animal organ regeneration 72 80 9 9 5 8 5 5 91 75 2376 0.92166 0.18126 0.22528 6.25 25664;24614;291234;114494;25649 pparg;orm1;mki67;ccna2;apoa2 PPARG_32510;ORM1_9400;MKI67_9232;CCNA2_8221;APOA2_33095 25664(0.0441) 38.119736 49.7822 3.54778 23.5952791155875 37.261456368218596 24.26378990332731 27.625567999999998 35.6665 1.51564 17.088855648758926 27.25195595304417 17.594948551225034 62.626470000000005 82.1147 8.55785 40.34102889567889 60.633260861851696 41.78252605036062 3.0 52.8265 60.1903;24.2519;49.7822;52.8265;3.54778 43.9036;19.7133;35.6665;37.3288;1.51564 101.057;31.358;82.1147;90.0448;8.55785 3 2 3 25664;24614;25649 PPARG_32510;ORM1_9400;APOA2_33095 29.329993333333334 24.2519 28.660670646621885 21.71084666666667 19.7133 21.264464083407635 46.99095 31.358 48.19040394059279 60.1903;24.2519;3.54778 43.9036;19.7133;1.51564 101.057;31.358;8.55785 2 291234;114494 MKI67_9232;CCNA2_8221 51.30435 51.30435 2.1526451739662855 36.49765 36.49765 1.1754236023664455 86.07974999999999 86.07974999999999 5.607427485487613 49.7822;52.8265 35.6665;37.3288 82.1147;90.0448 0 Exp 2,2(0.4);Hill,1(0.2);Linear,2(0.4) 2.187870320531156 11.446418642997742 1.5239794254302979 3.5849626064300537 0.803556278483527 2.285626173019409 17.43756196419037 58.80191003580964 12.646525587783959 42.60461041221605 27.265999105935656 97.98694089406433 UP 0.6 0.4 0.0 GO:0008284 6 positive regulation of cell population proliferation 272 293 6 6 4 6 4 4 92 289 2162 0.0098107 0.99715 0.020911 1.37 308761;64515;25599;114494 prc1;cdc20;cd74;ccna2 PRC1_9556;CDC20_8255;CD74_8252;CCNA2_8221 82.40245 87.60714999999999 52.8265 21.625953003509444 85.59743349662921 19.330167676730046 49.491600000000005 50.911500000000004 37.3288 8.938668319535415 51.420473982022465 8.513976188390359 215.2372 158.86700000000002 90.0448 165.1821327118241 207.77763868764046 157.88983190325007 80.3005;101.569;94.9138;52.8265 50.2731;51.5499;58.8146;37.3288 198.961;453.17;118.773;90.0448 1 3 1 25599 CD74_8252 94.9138 94.9138 58.8146 58.8146 118.773 118.773 94.9138 58.8146 118.773 3 308761;64515;114494 PRC1_9556;CDC20_8255;CCNA2_8221 78.23200000000001 80.3005 24.43699747820907 46.38393333333334 50.2731 7.867918042489575 247.39193333333333 198.961 186.3441552515489 80.3005;101.569;52.8265 50.2731;51.5499;37.3288 198.961;453.17;90.0448 0 Exp 2,1(0.25);Linear,2(0.5);Poly 2,1(0.25) 1.8045611387417646 7.311264514923096 1.5293418169021606 2.3255980014801025 0.3495977148222888 1.7281623482704163 61.20901605656073 103.59588394343928 40.73170504685527 58.25149495314474 53.35870994241242 377.11569005758764 DOWN 0.25 0.75 0.0 GO:0010045 6 response to nickel cation 1 2 1 1 1 1 1 1 95 1 2450 0.99859 0.073976 0.073976 50.0 65155 alas1 ALAS1_8018 27.1843 27.1843 27.1843 27.1843 21.5215 21.5215 21.5215 21.5215 36.6615 36.6615 36.6615 36.6615 0.0 27.1843 0.0 27.1843 27.1843 21.5215 36.6615 1 0 1 65155 ALAS1_8018 27.1843 27.1843 21.5215 21.5215 36.6615 36.6615 27.1843 21.5215 36.6615 0 0 Linear,1(1) 1.8392632007598877 1.8392632007598877 1.8392632007598877 1.8392632007598877 0.0 1.8392632007598877 27.1843 27.1843 21.5215 21.5215 36.6615 36.6615 UP 1.0 0.0 0.0 GO:0032355 5 response to estradiol 114 121 5 5 4 5 4 4 92 117 2334 0.51616 0.67902 1.0 3.31 24950;24484;114494;140668 srd5a1;igfbp3;ccna2;abcc3 SRD5A1_32503;IGFBP3_8881;CCNA2_8221;ABCC3_7941 41.939675 42.86175 29.2087 11.73330478832938 42.1078164058851 11.553156379381337 30.805975000000004 31.48215 22.9308 7.1194484647688725 30.917430698271836 7.0068629331451 66.220525 67.42605 39.9852 25.04816579969814 66.51548631480617 24.6766339838529 29.2087;50.946;52.8265;34.7775 22.9308;36.3081;37.3288;26.6562 39.9852;85.0816;90.0448;49.7705 1 3 1 140668 ABCC3_7941 34.7775 34.7775 26.6562 26.6562 49.7705 49.7705 34.7775 26.6562 49.7705 3 24950;24484;114494 SRD5A1_32503;IGFBP3_8881;CCNA2_8221 44.32706666666667 50.946 13.126607637288968 32.189233333333334 36.3081 8.034263996367907 71.70386666666667 85.0816 27.581038774733106 29.2087;50.946;52.8265 22.9308;36.3081;37.3288 39.9852;85.0816;90.0448 0 Linear,4(1) 1.9923981905205594 8.012900590896606 1.7380040884017944 2.3255980014801025 0.24289337444167183 1.9746492505073547 30.4410363074372 53.4383136925628 23.828915504526492 37.78303449547351 41.673322516295855 90.76772748370416 DOWN 0.25 0.75 0.0 GO:0051640 4 organelle localization 71 74 2 2 2 2 2 2 94 72 2379 0.46571 0.77739 1.0 2.7 361604;293502 sytl2;kif22 SYTL2_32351;KIF22_8963 70.46340000000001 70.46340000000001 67.0093 4.884835065792892 70.33301755542242 4.881353752422723 45.99905 45.99905 44.4373 2.208648031036309 45.940098382264836 2.2070739766788354 150.631 150.631 135.846 20.909147519686265 150.0729083283403 20.894246035022466 67.0093;73.9175 44.4373;47.5608 135.846;165.416 0 2 0 2 361604;293502 SYTL2_32351;KIF22_8963 70.46340000000001 70.46340000000001 4.884835065792892 45.99905 45.99905 2.208648031036309 150.631 150.631 20.909147519686265 67.0093;73.9175 44.4373;47.5608 135.846;165.416 0 Linear,2(1) 1.7480703831428865 3.532942533493042 1.512166976928711 2.020775556564331 0.3596405756300052 1.766471266746521 63.693364 77.23343600000001 42.938019999999995 49.06008 121.65240000000001 179.6096 DOWN 0.0 1.0 0.0 GO:0032496 5 response to lipopolysaccharide 176 189 9 8 8 9 7 7 89 182 2269 0.57951 0.57799 1.0 3.7 286954;84386;24614;315994;24484;63868;140668 ugt2b1;slpi;orm1;mapkapk3;igfbp3;hspd1;abcc3 UGT2B10_33303,UGT2B1_33224;SLPI_9890;ORM1_9400;MAPKAPK3_9194;IGFBP3_8881;HSPD1_8849;ABCC3_7941 44.985850000000006 34.7775 12.54415 29.763976809741553 46.936625132060136 30.708495956368413 30.52892071428571 26.6907 7.348245 16.282509888865523 31.61942446566436 16.560090294128937 109.67423571428571 49.7705 25.495849999999997 145.64643157428287 117.83619223215496 152.129119152091 12.54415;53.7429;24.2519;104.193;50.946;34.4455;34.7775 7.348245;37.8192;19.7133;59.1667;36.3081;26.6907;26.6562 25.495849999999997;92.543;31.358;434.985;85.0816;48.4857;49.7705 5 3 4 286954;24614;63868;140668 UGT2B10_33303,UGT2B1_33224;ORM1_9400;HSPD1_8849;ABCC3_7941 26.504762500000002 29.3487 10.511384124000596 20.10211125 23.18475 9.113686769003323 38.7775125 39.92185 12.2003606942838 12.54415;24.2519;34.4455;34.7775 7.348245;19.7133;26.6907;26.6562 25.495849999999997;31.358;48.4857;49.7705 3 84386;315994;24484 SLPI_9890;MAPKAPK3_9194;IGFBP3_8881 69.62729999999999 53.7429 29.967421890613185 44.431333333333335 37.8192 12.783549151285525 204.2032 92.543 199.89771767311404 53.7429;104.193;50.946 37.8192;59.1667;36.3081 92.543;434.985;85.0816 0 Exp 2,2(0.25);Exp 4,1(0.13);Linear,4(0.5);Poly 2,1(0.13) 1.8731392684980008 15.572288036346436 1.5163835287094116 3.5849626064300537 0.6759170549246424 1.721932053565979 22.936387413276453 67.03531258672355 18.46666858623704 42.59117284233439 1.777849273215054 217.57062215535635 CONFLICT 0.5714285714285714 0.42857142857142855 0.0 GO:0050727 6 regulation of inflammatory response 108 115 7 7 5 7 5 5 91 110 2341 0.73591 0.43879 0.61984 4.35 84386;25664;259241;63868;25599 slpi;pparg;nr1d2;hspd1;cd74 SLPI_9890;PPARG_32510;NR1D2_9358;HSPD1_8849;CD74_8252 25664(0.0441) 68.46318 60.1903 34.4455 27.73036280049361 66.46402881111625 25.262387396519422 41.956759999999996 42.5557 26.6907 11.602884073065646 42.916855027675275 11.589434047084644 92.73934000000001 101.057 48.4857 26.492173642945872 94.80966145929428 24.76537245392048 53.7429;60.1903;99.0234;34.4455;94.9138 37.8192;43.9036;42.5557;26.6907;58.8146 92.543;101.057;102.838;48.4857;118.773 4 1 4 25664;259241;63868;25599 PPARG_32510;NR1D2_9358;HSPD1_8849;CD74_8252 72.14325 77.55205 30.5779538234657 42.99115 43.22965 13.128955553914668 92.78842499999999 101.94749999999999 30.590264630911037 60.1903;99.0234;34.4455;94.9138 43.9036;42.5557;26.6907;58.8146 101.057;102.838;48.4857;118.773 1 84386 SLPI_9890 53.7429 53.7429 37.8192 37.8192 92.543 92.543 53.7429 37.8192 92.543 0 Exp 2,2(0.4);Linear,1(0.2);Poly 2,1(0.2);Power,1(0.2) 1.8123472837544228 9.278570771217346 1.5239794254302979 2.7270524501800537 0.4920683910809495 1.6577342748641968 44.15644530504703 92.76991469495299 31.78638369120965 52.127136308790355 69.51792595415668 115.96075404584332 UP 0.8 0.2 0.0 GO:0008286 8 insulin receptor signaling pathway 24 24 2 2 2 2 2 2 94 22 2429 0.94078 0.22823 0.22823 8.33 78968;25685 srebf1;igfbp1 SREBF1_32750;IGFBP1_32306 70.019 70.019 41.2009 40.75494786182409 49.80546109620544 29.048088838847352 44.4072 44.4072 31.4864 18.272770596710274 35.34431613645074 13.023917130864948 208.7432 208.7432 60.0774 210.2451906210461 104.46630693752394 149.8522583271733 0.5 70.019 41.2009;98.8371 31.4864;57.328 60.0774;357.409 2 0 2 78968;25685 SREBF1_32750;IGFBP1_32306 70.019 70.019 40.75494786182409 44.4072 44.4072 18.272770596710274 208.7432 208.7432 210.2451906210461 41.2009;98.8371 31.4864;57.328 60.0774;357.409 0 0 Exp 2,1(0.5);Linear,1(0.5) 1.9713418734476105 3.944490671157837 1.912555456161499 2.031935214996338 0.08441423700852922 1.9722453355789185 13.535523999999995 126.50247600000002 19.082432000000004 69.731968 -82.64176799999996 500.12816799999996 UP 1.0 0.0 0.0 GO:0046459 7 short-chain fatty acid metabolic process 7 7 3 3 2 3 2 2 94 5 2446 0.99837 0.026092 0.026092 28.57 311849;681337 crat;acot4 CRAT_8375;ACOT4_7971 10.650435 10.650435 8.98517 2.3550403479452306 9.931450531509526 2.1242263788468816 4.342365 4.342365 1.97988 3.341058327903001 3.322353156814851 3.0136062168063815 27.88595 27.88595 24.3993 4.9308677172481215 29.39132433805569 4.447600774535276 0.0 8.98517 0.0 8.98517 8.98517;12.3157 1.97988;6.70485 31.3726;24.3993 2 0 2 311849;681337 CRAT_8375;ACOT4_7971 10.650435 10.650435 2.3550403479452306 4.342365 4.342365 3.341058327903001 27.88595 27.88595 4.9308677172481215 8.98517;12.3157 1.97988;6.70485 31.3726;24.3993 0 0 Hill,2(1) 2.2177894980112716 4.57741379737854 1.7233848571777344 2.8540289402008057 0.7994860982140596 2.28870689868927 7.386515600000001 13.914354399999999 -0.28810559999999885 8.9728356 21.052116000000005 34.719784 UP 1.0 0.0 0.0 GO:0010648 6 negative regulation of cell communication 320 334 15 15 12 15 12 12 84 322 2129 0.50321 0.61925 1.0 3.59 29142;365813;78968;25664;24484;24471;29455;58868;65210;25599;25649;170465 vnn1;trim59;srebf1;pparg;igfbp3;hspb1;gdf15;fzd1;cyp2j4;cd74;apoa2;acaa2 VNN1_10157;TRIM59_10085;SREBF1_32750;PPARG_32510;IGFBP3_8881;HSPB1_8847;GDF15_33113;FZD1_8671;CYP2J4_32580;CD74_8252;APOA2_33095;ACAA2_7955 25664(0.0441) 42.55018999999999 41.41655 3.54778 27.018417121399384 46.859152139997285 27.947023554115837 28.070594999999997 31.2179 1.51564 16.764840280320715 30.444261136047942 17.63506505634853 73.26332916666667 74.2006 8.55785 42.16303110062209 78.64838974874029 39.66276546974406 20.7328;56.1278;41.2009;60.1903;50.946;41.6322;21.3654;25.231;16.3155;94.9138;3.54778;78.3988 16.8296;33.6269;31.4864;43.9036;36.3081;30.9494;17.8875;13.6792;8.2378;58.8146;1.51564;43.6084 26.7838;121.883;60.0774;101.057;85.0816;63.3196;26.3528;131.659;36.8422;118.773;8.55785;98.7727 9 3 9 29142;78968;25664;24471;29455;58868;65210;25599;25649 VNN1_10157;SREBF1_32750;PPARG_32510;HSPB1_8847;GDF15_33113;FZD1_8671;CYP2J4_32580;CD74_8252;APOA2_33095 36.12552 25.231 27.65522573114528 24.811526666666666 17.8875 18.22056677961473 63.71362777777777 60.0774 44.13033256759963 20.7328;41.2009;60.1903;41.6322;21.3654;25.231;16.3155;94.9138;3.54778 16.8296;31.4864;43.9036;30.9494;17.8875;13.6792;8.2378;58.8146;1.51564 26.7838;60.0774;101.057;63.3196;26.3528;131.659;36.8422;118.773;8.55785 3 365813;24484;170465 TRIM59_10085;IGFBP3_8881;ACAA2_7955 61.8242 56.1278 14.585979112832971 37.8478 36.3081 5.165809968436699 101.91243333333334 98.7727 18.600516244000584 56.1278;50.946;78.3988 33.6269;36.3081;43.6084 121.883;85.0816;98.7727 0 Exp 2,4(0.34);Exp 4,1(0.09);Hill,1(0.09);Linear,3(0.25);Poly 2,3(0.25) 2.026585872330078 26.739336133003235 1.5124053955078125 5.015069484710693 1.2182310222109582 1.7333461046218872 27.263081409844833 57.837298590155186 18.58499365221104 37.556196347788955 49.40734855798783 97.1193097753455 UP 0.75 0.25 0.0 GO:0051276 6 chromosome organization 85 90 8 8 8 8 8 8 88 82 2369 0.99408 0.018418 0.018418 8.89 257644;360243;304951;316273;293502;303575;64515;362485 zwint;top2a;nuf2;mcm3;kif22;kif18b;cdc20;ccne2 ZWINT_10214;TOP2A_10059;NUF2_33136;MCM3_9207;KIF22_8963;KIF18B_32882;CDC20_8255;CCNE2_8227 60.92332500000008 62.5243 5.73955E-13 29.11287370566726 62.59952617403889 22.79662669711646 35.62555000000007 42.26745 5.73955E-13 17.85993098274923 37.658966236047995 14.151239807527938 171.80537500000005 148.673 5.73957E-13 131.11427203772337 164.17004764365447 116.21469079913662 3.5 62.5243 59.0663;54.9577;5.73955E-13;54.0045;73.9175;65.9823;101.569;77.8893 40.5797;18.8326;5.73955E-13;33.259;47.5608;43.9552;51.5499;49.2672 108.188;218.525;5.73957E-13;111.753;165.416;131.93;453.17;185.461 1 7 1 257644 ZWINT_10214 59.0663 59.0663 40.5797 40.5797 108.188 108.188 59.0663 40.5797 108.188 7 360243;304951;316273;293502;303575;64515;362485 TOP2A_10059;NUF2_33136;MCM3_9207;KIF22_8963;KIF18B_32882;CDC20_8255;CCNE2_8227 61.18861428571437 65.9823 31.435051341691018 34.917814285714364 43.9552 19.169377106244784 180.8935714285715 165.416 138.87124055620382 54.9577;5.73955E-13;54.0045;73.9175;65.9823;101.569;77.8893 18.8326;5.73955E-13;33.259;47.5608;43.9552;51.5499;49.2672 218.525;5.73957E-13;111.753;165.416;131.93;453.17;185.461 0 Exp 2,3(0.38);Hill,1(0.13);Linear,4(0.5) 1.7109620617251395 13.742541790008545 1.5293418169021606 2.020775556564331 0.16656844234150245 1.690821886062622 40.7491327912373 81.09751720876284 23.249249256762894 48.001850743237256 80.94781994915245 262.6629300508477 DOWN 0.125 0.875 0.0 GO:0044242 5 cellular lipid catabolic process 56 64 15 15 13 15 13 13 83 51 2400 1.0 3.683E-7 3.683E-7 20.31 364975;171142;291075;29740;64526;117543;311849;25413;25649;502970;50681;192272;170465 gcdh;ehhadh;eci2;eci1;ech1;decr1;crat;cpt2;apoa2;angptl3;acox1;acot2;acaa2 GCDH_8693;EHHADH_8534;ECI2_8521;ECI1_8520;ECH1_8516;DECR1_8458;CRAT_8375;CPT2_8374;APOA2_33095;ANGPTL3_8045;ACOX1_7973;ACOT2_7969;ACAA2_7955 22.52695307692308 13.6362 3.54778 22.037504411349676 25.74339952298703 24.59418364626972 15.055657692307692 10.4227 1.51564 13.72232478266417 16.959294724250068 15.28591271656157 35.49821923076923 28.0829 8.55785 30.923545798977752 41.036414439256745 35.86940421736653 2.5 8.857145 5.5 12.70075 15.9021;7.29984;8.72912;11.7653;9.87438;21.6199;8.98517;31.2175;3.54778;58.0729;23.8014;13.6362;78.3988 10.4227;5.26587;5.10151;8.40998;6.59127;17.4928;1.97988;24.8356;1.51564;40.0757;19.0993;11.3249;43.6084 31.2818;11.8779;17.7951;18.8402;19.44;28.0829;31.3726;42.0237;8.55785;105.112;31.3543;16.9658;98.7727 12 1 12 364975;171142;291075;29740;64526;117543;311849;25413;25649;502970;50681;192272 GCDH_8693;EHHADH_8534;ECI2_8521;ECI1_8520;ECH1_8516;DECR1_8458;CRAT_8375;CPT2_8374;APOA2_33095;ANGPTL3_8045;ACOX1_7973;ACOT2_7969 17.870965833333333 12.70075 14.911915074309755 12.676262499999998 9.41634 11.186148164044127 30.225345833333336 23.76145 25.473497768852905 15.9021;7.29984;8.72912;11.7653;9.87438;21.6199;8.98517;31.2175;3.54778;58.0729;23.8014;13.6362 10.4227;5.26587;5.10151;8.40998;6.59127;17.4928;1.97988;24.8356;1.51564;40.0757;19.0993;11.3249 31.2818;11.8779;17.7951;18.8402;19.44;28.0829;31.3726;42.0237;8.55785;105.112;31.3543;16.9658 1 170465 ACAA2_7955 78.3988 78.3988 43.6084 43.6084 98.7727 98.7727 78.3988 43.6084 98.7727 0 Exp 2,1(0.08);Hill,5(0.39);Linear,4(0.31);Poly 2,3(0.24) 2.169015298402268 30.661600828170776 1.5375925302505493 4.473705768585205 1.082417914580535 1.72868812084198 10.547229216058861 34.5066769377873 7.596116967689755 22.515198416925628 18.687988246549867 52.308450214988596 UP 0.9230769230769231 0.07692307692307693 0.0 GO:0055114 3 oxidation-reduction process 260 296 33 33 29 33 29 29 67 267 2184 1.0 4.5926E-7 4.5926E-7 9.8 24950;25664;363465;680308;24552;313200;364975;171142;291075;29740;64526;117543;114027;25427;50549;266682;65210;25086;24303;499353;171521;29277;24894;311849;25413;25649;26760;50681;170465 srd5a1;pparg;pir;mthfd2;me1;hsdl2;gcdh;ehhadh;eci2;eci1;ech1;decr1;dao;cyp51;cyp4a1;cyp3a2;cyp2j4;cyp2e1;cyp2d3;cyp2c24;cyp2c13;cyp2c11;cyp2a1;crat;cpt2;apoa2;akr7a3;acox1;acaa2 SRD5A1_32503;PPARG_32510;PIR_9487;MTHFD2_9261;ME1_9215;HSDL2_8837;GCDH_8693;EHHADH_8534;ECI2_8521;ECI1_8520;ECH1_8516;DECR1_8458;DAO_8437;CYP51_8429;CYP4A1_33111;CYP3A2_32374;CYP2J4_32580;CYP2E1_8421;CYP2D3_8420;CYP2C24_32875;CYP2C13_8419;CYP2C11_32593;CYP2A1_32717;CRAT_8375;CPT2_8374;APOA2_33095;AKR7A3_8015;ACOX1_7973;ACAA2_7955 25664(0.0441) 31.977758620689656 23.208 3.54778 26.340894707284217 34.65626892770468 27.515392239941175 21.904077586206892 18.6955 1.51564 17.19488348693871 23.397443722755725 17.507412655636415 49.96735344827586 31.3726 8.55785 38.05236159884526 52.38500808967825 33.942428149302195 13.5 22.41395 29.2087;60.1903;52.1607;57.4184;49.3339;46.9509;15.9021;7.29984;8.72912;11.7653;9.87438;21.6199;6.1336;75.1522;23.208;23.2485;16.3155;7.89174;12.8059;58.9435;104.635;54.426;9.37187;8.98517;31.2175;3.54778;18.819;23.8014;78.3988 22.9308;43.9036;40.9644;46.387;35.4173;34.073;10.4227;5.26587;5.10151;8.40998;6.59127;17.4928;2.43617;48.098;18.863;18.6955;8.2378;4.16797;8.8664;48.1505;49.2461;43.9518;4.95906;1.97988;24.8356;1.51564;11.5469;19.0993;43.6084 39.9852;101.057;74.9097;79.7903;80.9924;75.2094;31.2818;11.8779;17.7951;18.8402;19.44;28.0829;16.2027;171.379;29.9853;30.5145;36.8422;15.8079;22.6004;80.4167;108.327;74.8861;19.1079;31.3726;42.0237;8.55785;51.6405;31.3543;98.7727 26 3 26 25664;363465;680308;24552;313200;364975;171142;291075;29740;64526;117543;114027;50549;266682;65210;25086;24303;499353;171521;29277;24894;311849;25413;25649;26760;50681 PPARG_32510;PIR_9487;MTHFD2_9261;ME1_9215;HSDL2_8837;GCDH_8693;EHHADH_8534;ECI2_8521;ECI1_8520;ECH1_8516;DECR1_8458;DAO_8437;CYP4A1_33111;CYP3A2_32374;CYP2J4_32580;CYP2E1_8421;CYP2D3_8420;CYP2C24_32875;CYP2C13_8419;CYP2C11_32593;CYP2A1_32717;CRAT_8375;CPT2_8374;APOA2_33095;AKR7A3_8015;ACOX1_7973 28.638280769230768 20.219450000000002 24.585384661881204 20.022348076923077 14.51985 16.76696229046586 43.804475 31.31805 29.888861639819112 60.1903;52.1607;57.4184;49.3339;46.9509;15.9021;7.29984;8.72912;11.7653;9.87438;21.6199;6.1336;23.208;23.2485;16.3155;7.89174;12.8059;58.9435;104.635;54.426;9.37187;8.98517;31.2175;3.54778;18.819;23.8014 43.9036;40.9644;46.387;35.4173;34.073;10.4227;5.26587;5.10151;8.40998;6.59127;17.4928;2.43617;18.863;18.6955;8.2378;4.16797;8.8664;48.1505;49.2461;43.9518;4.95906;1.97988;24.8356;1.51564;11.5469;19.0993 101.057;74.9097;79.7903;80.9924;75.2094;31.2818;11.8779;17.7951;18.8402;19.44;28.0829;16.2027;29.9853;30.5145;36.8422;15.8079;22.6004;80.4167;108.327;74.8861;19.1079;31.3726;42.0237;8.55785;51.6405;31.3543 3 24950;25427;170465 SRD5A1_32503;CYP51_8429;ACAA2_7955 60.91989999999999 75.1522 27.510638977857276 38.2124 43.6084 13.423285773609972 103.37896666666666 98.7727 65.81789983783543 29.2087;75.1522;78.3988 22.9308;48.098;43.6084 39.9852;171.379;98.7727 0 Exp 2,7(0.25);Exp 4,3(0.11);Hill,6(0.21);Linear,7(0.25);Poly 2,5(0.18);Power,1(0.04) 2.017710885846195 61.35311281681061 1.5239794254302979 3.9502921104431152 0.7359209560559378 1.8166091442108154 22.39065117360135 41.56486606777796 15.645778566323601 28.16237660609019 36.11770698343111 63.816999913120604 UP 0.896551724137931 0.10344827586206896 0.0 GO:0046889 7 positive regulation of lipid biosynthetic process 46 50 3 3 2 3 2 2 94 48 2403 0.70895 0.56917 0.71286 4.0 78968;25599 srebf1;cd74 SREBF1_32750;CD74_8252 68.05735 68.05735 41.2009 37.98075582719492 66.7620126335675 37.936552497812045 45.1505 45.1505 31.4864 19.323955537622194 44.491454619517086 19.30146564364813 89.42519999999999 89.42519999999999 60.0774 41.50405678581317 88.0097001121672 41.455752915790654 41.2009;94.9138 31.4864;58.8146 60.0774;118.773 2 0 2 78968;25599 SREBF1_32750;CD74_8252 68.05735 68.05735 37.98075582719492 45.1505 45.1505 19.323955537622194 89.42519999999999 89.42519999999999 41.50405678581317 41.2009;94.9138 31.4864;58.8146 60.0774;118.773 0 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.78059224199631 3.570289731025696 1.6577342748641968 1.912555456161499 0.18018578528528906 1.785144865512848 15.41870800000001 120.69599199999999 18.368864000000002 71.932136 31.903511999999992 146.946888 UP 1.0 0.0 0.0 GO:0044339 9 canonical Wnt signaling pathway involved in osteoblast differentiation 1 1 1 1 1 1 1 1 95 0 2451 1.0 0.037691 0.037691 100.0 58868 fzd1 FZD1_8671 25.231 25.231 25.231 25.231 13.6792 13.6792 13.6792 13.6792 131.659 131.659 131.659 131.659 0.0 25.231 0.0 25.231 25.231 13.6792 131.659 1 0 1 58868 FZD1_8671 25.231 25.231 13.6792 13.6792 131.659 131.659 25.231 13.6792 131.659 0 0 Poly 2,1(1) 1.5124053955078125 1.5124053955078125 1.5124053955078125 1.5124053955078125 0.0 1.5124053955078125 25.231 25.231 13.6792 13.6792 131.659 131.659 UP 1.0 0.0 0.0 GO:0018193 7 peptidyl-amino acid modification 169 184 4 4 2 3 2 2 94 182 2269 0.025029 0.99431 0.043688 1.09 315994;25649 mapkapk3;apoa2 MAPKAPK3_9194;APOA2_33095 53.87039 53.87039 3.54778 71.16691755601194 58.04606333282582 70.92148940102186 30.341169999999998 30.341169999999998 1.51564 40.76545546859252 32.73305700517662 40.624870617279925 221.771425 221.771425 8.55785 301.5295294470531 239.46347712774056 300.4896665637271 104.193;3.54778 59.1667;1.51564 434.985;8.55785 1 1 1 25649 APOA2_33095 3.54778 3.54778 1.51564 1.51564 8.55785 8.55785 3.54778 1.51564 8.55785 1 315994 MAPKAPK3_9194 104.193 104.193 59.1667 59.1667 434.985 434.985 104.193 59.1667 434.985 0 Hill,1(0.5);Linear,1(0.5) 1.6179186510180807 3.24263596534729 1.5163835287094116 1.7262524366378784 0.14839972795643405 1.621317982673645 -44.761925599999984 152.50270559999998 -26.15686879999999 86.8392088 -196.12718199999998 639.670032 CONFLICT 0.5 0.5 0.0 GO:0044093 4 positive regulation of molecular function 417 443 12 12 8 12 8 8 88 435 2016 0.0081663 0.99686 0.013449 1.81 25664;63868;29455;299626;58868;64515;25599;25649 pparg;hspd1;gdf15;gadd45b;fzd1;cdc20;cd74;apoa2 PPARG_32510;HSPD1_8849;GDF15_33113;GADD45B_8679;FZD1_8671;CDC20_8255;CD74_8252;APOA2_33095 25664(0.0441) 49.2293225 43.50865 3.54778 35.082577893625995 54.463420073372184 33.76857256681992 31.404117500000005 31.94125 1.51564 19.85422040678774 35.05727728648694 19.72225647313201 122.17691875 95.2085 8.55785 140.76468090195257 121.81085429227285 127.23746725130297 60.1903;34.4455;21.3654;52.5718;25.231;101.569;94.9138;3.54778 43.9036;26.6907;17.8875;37.1918;13.6792;51.5499;58.8146;1.51564 101.057;48.4857;26.3528;89.36;131.659;453.17;118.773;8.55785 7 1 7 25664;63868;29455;299626;58868;25599;25649 PPARG_32510;HSPD1_8849;GDF15_33113;GADD45B_8679;FZD1_8671;CD74_8252;APOA2_33095 41.752225714285714 34.4455 30.23441809823084 28.52614857142857 26.6907 19.559733242536332 74.89219285714286 89.36 47.4263126180888 60.1903;34.4455;21.3654;52.5718;25.231;94.9138;3.54778 43.9036;26.6907;17.8875;37.1918;13.6792;58.8146;1.51564 101.057;48.4857;26.3528;89.36;131.659;118.773;8.55785 1 64515 CDC20_8255 101.569 101.569 51.5499 51.5499 453.17 453.17 101.569 51.5499 453.17 0 Exp 2,4(0.5);Hill,1(0.13);Linear,1(0.13);Poly 2,2(0.25) 1.837682605944013 16.173354387283325 1.5124053955078125 5.015069484710693 1.2120416618132444 1.6042857766151428 24.91833634451356 73.54030865548643 17.64584469288429 45.162390307115714 24.63197154101546 219.72186595898455 UP 0.875 0.125 0.0 GO:0015711 6 organic anion transport 106 111 10 10 8 10 8 8 88 103 2348 0.97798 0.055018 0.067779 7.21 117267;83500;503568;25664;296371;25413;25649;140668 slc26a2;slc22a8;slc13a4;pparg;pltp;cpt2;apoa2;abcc3 SLC26A2_33072;SLC22A8_9848;SLC13A4_9836;PPARG_32510;PLTP_32412;CPT2_8374;APOA2_33095;ABCC3_7941 25664(0.0441) 48.70226 53.61785 3.54778 25.288052817197507 50.46519637464937 24.958432564809904 33.9656175 37.7491 1.51564 16.50766478678119 35.25888148136103 16.49777960973748 78.27444375 92.23975 8.55785 41.24686450371917 79.56542541058579 37.12846086237065 4.5 57.467749999999995 54.7452;52.4905;65.6237;60.1903;87.0256;31.2175;3.54778;34.7775 38.3503;37.1479;42.6891;43.9036;56.6266;24.8356;1.51564;26.6562 95.3373;89.1422;135.744;101.057;104.563;42.0237;8.55785;49.7705 6 2 6 83500;25664;296371;25413;25649;140668 SLC22A8_9848;PPARG_32510;PLTP_32412;CPT2_8374;APOA2_33095;ABCC3_7941 44.87486333333334 43.634 28.515445849631494 31.780923333333334 31.90205 18.886815813282734 65.852375 69.45635 38.44317652993508 52.4905;60.1903;87.0256;31.2175;3.54778;34.7775 37.1479;43.9036;56.6266;24.8356;1.51564;26.6562 89.1422;101.057;104.563;42.0237;8.55785;49.7705 2 117267;503568 SLC26A2_33072;SLC13A4_9836 60.18445 60.18445 7.692261119137861 40.5197 40.5197 3.067994902212159 115.54065 115.54065 28.571851575370424 54.7452;65.6237 38.3503;42.6891 95.3373;135.744 0 Exp 2,3(0.38);Hill,1(0.13);Linear,3(0.38);Poly 2,1(0.13) 1.659463997888436 13.344554424285889 1.5084086656570435 1.998015284538269 0.18549866731361214 1.5935340523719788 31.178533442556944 66.22598655744308 22.526389421958392 45.40484557804162 49.69182490860271 106.85706259139727 UP 0.75 0.25 0.0 GO:0000185 10 activation of MAPKKK activity 4 5 1 1 1 1 1 1 95 4 2447 0.98695 0.1749 0.1749 20.0 299626 gadd45b GADD45B_8679 52.5718 52.5718 52.5718 52.5718 37.1918 37.1918 37.1918 37.1918 89.36 89.36 89.36 89.36000000000001 0.0 52.5718 0.0 52.5718 52.5718 37.1918 89.36 1 0 1 299626 GADD45B_8679 52.5718 52.5718 37.1918 37.1918 89.36 89.36 52.5718 37.1918 89.36 0 0 Linear,1(1) 1.5528020858764648 1.5528020858764648 1.5528020858764648 1.5528020858764648 0.0 1.5528020858764648 52.5718 52.5718 37.1918 37.1918 89.36 89.36 UP 1.0 0.0 0.0 GO:0045926 5 negative regulation of growth 66 72 5 5 2 5 2 2 94 70 2381 0.48449 0.76408 1.0 2.78 25664;29455 pparg;gdf15 PPARG_32510;GDF15_33113 25664(0.0441) 40.77785 40.77785 21.3654 27.45335006888959 55.3371875 18.158684234469945 30.89555 30.89555 17.8875 18.396160730027333 40.6515875 12.167916592506181 63.7049 63.7049 26.3528 52.823846403116086 91.718975 34.93969021912975 60.1903;21.3654 43.9036;17.8875 101.057;26.3528 2 0 2 25664;29455 PPARG_32510;GDF15_33113 40.77785 40.77785 27.45335006888959 30.89555 30.89555 18.396160730027333 63.7049 63.7049 52.823846403116086 60.1903;21.3654 43.9036;17.8875 101.057;26.3528 0 0 Exp 2,2(1) 2.7645727901074375 6.539048910140991 1.5239794254302979 5.015069484710693 2.4685734546501137 3.2695244550704956 2.729448000000005 78.826252 5.399772000000006 56.391327999999994 -9.505215999999997 136.915016 UP 1.0 0.0 0.0 GO:1903900 6 regulation of viral life cycle 36 38 4 4 4 4 4 4 92 34 2417 0.98718 0.052533 0.052533 10.53 365813;360243;84386;25599 trim59;top2a;slpi;cd74 TRIM59_10085;TOP2A_10059;SLPI_9890;CD74_8252 64.93555 55.54275 53.7429 20.009204863178976 66.04545773410646 20.806951963224993 37.273325 35.72305 18.8326 16.509404006479667 39.623517995902915 15.587607248560687 137.931 120.328 92.543 55.31735908374509 127.27670042706852 48.19417837219549 0.5 54.350300000000004 2.5 75.5208 56.1278;54.9577;53.7429;94.9138 33.6269;18.8326;37.8192;58.8146 121.883;218.525;92.543;118.773 1 3 1 25599 CD74_8252 94.9138 94.9138 58.8146 58.8146 118.773 118.773 94.9138 58.8146 118.773 3 365813;360243;84386 TRIM59_10085;TOP2A_10059;SLPI_9890 54.942800000000005 54.9577 1.1925198153485892 30.0929 33.6269 9.974447949134845 144.317 121.883 65.91911216028319 56.1278;54.9577;53.7429 33.6269;18.8326;37.8192 121.883;218.525;92.543 0 Exp 2,2(0.5);Linear,1(0.25);Poly 2,1(0.25) 1.6736254120047631 6.706691265106201 1.528815746307373 1.8061060905456543 0.1160018652338851 1.685884714126587 45.32652923408456 84.54457076591542 21.094109073649935 53.45254092635007 83.71998809792979 192.14201190207024 DOWN 0.25 0.75 0.0 GO:0032880 5 regulation of protein localization 255 275 9 9 7 9 7 7 89 268 2183 0.16876 0.90863 0.31569 2.55 78968;24614;63868;25427;65210;362485;25649 srebf1;orm1;hspd1;cyp51;cyp2j4;ccne2;apoa2 SREBF1_32750;ORM1_9400;HSPD1_8849;CYP51_8429;CYP2J4_32580;CCNE2_8227;APOA2_33095 38.971868571428566 34.4455 3.54778 28.383956758285983 29.871687132466285 21.671975746420596 26.429862857142858 26.6907 1.51564 18.318800029377574 20.989488208574183 15.195806348541378 77.45159285714286 48.4857 8.55785 70.88648821173204 52.86570847904623 49.48839146519468 41.2009;24.2519;34.4455;75.1522;16.3155;77.8893;3.54778 31.4864;19.7133;26.6907;48.098;8.2378;49.2672;1.51564 60.0774;31.358;48.4857;171.379;36.8422;185.461;8.55785 5 2 5 78968;24614;63868;65210;25649 SREBF1_32750;ORM1_9400;HSPD1_8849;CYP2J4_32580;APOA2_33095 23.952315999999996 24.2519 14.852410233941164 17.528768 19.7133 12.512703782561147 37.064229999999995 36.8422 19.398969233235054 41.2009;24.2519;34.4455;16.3155;3.54778 31.4864;19.7133;26.6907;8.2378;1.51564 60.0774;31.358;48.4857;36.8422;8.55785 2 25427;362485 CYP51_8429;CCNE2_8227 76.52074999999999 76.52074999999999 1.9354219707862548 48.6826 48.6826 0.8267492485630882 178.42000000000002 178.42000000000002 9.957477692668805 75.1522;77.8893 48.098;49.2672 171.379;185.461 0 Exp 2,3(0.43);Exp 4,1(0.15);Hill,1(0.15);Linear,2(0.29) 1.927272059216826 14.043423652648926 1.589782476425171 3.5849626064300537 0.7093387881146062 1.7262524366378784 17.944739145626563 59.99899799723058 12.85910588258324 40.00061983170248 24.93814750271555 129.96503821157017 UP 0.7142857142857143 0.2857142857142857 0.0 GO:0007026 8 negative regulation of microtubule depolymerization 9 10 1 1 1 1 1 1 95 9 2442 0.94805 0.31948 0.31948 10.0 306575 ckap2 CKAP2_8324 64.2131 64.2131 64.2131 64.2131 43.1133 43.1133 43.1133 43.1133 125.437 125.437 125.437 125.437 0.0 64.2131 0.0 64.2131 64.2131 43.1133 125.437 0 1 0 1 306575 CKAP2_8324 64.2131 64.2131 43.1133 43.1133 125.437 125.437 64.2131 43.1133 125.437 0 Linear,1(1) 2.6341071128845215 2.6341071128845215 2.6341071128845215 2.6341071128845215 0.0 2.6341071128845215 64.2131 64.2131 43.1133 43.1133 125.437 125.437 DOWN 0.0 1.0 0.0 GO:0046272 6 stilbene catabolic process 1 1 1 1 1 1 1 1 95 0 2451 1.0 0.037691 0.037691 100.0 65030 ephx2 EPHX2_33282 6.44145 6.44145 6.44145 6.44145 2.66377 2.66377 2.66377 2.66377 17.3473 17.3473 17.3473 17.3473 0.0 6.44145 0.0 6.44145 6.44145 2.66377 17.3473 1 0 1 65030 EPHX2_33282 6.44145 6.44145 2.66377 2.66377 17.3473 17.3473 6.44145 2.66377 17.3473 0 0 Exp 4,1(1) 2.3739430904388428 2.3739430904388428 2.3739430904388428 2.3739430904388428 0.0 2.3739430904388428 6.44145 6.44145 2.66377 2.66377 17.3473 17.3473 UP 1.0 0.0 0.0 GO:0051171 5 regulation of nitrogen compound metabolic process 917 985 35 34 25 34 24 24 72 961 1490 0.002861 0.99861 0.0052512 2.44 360243;78968;84386;299270;24679;25664;363465;54133;65035;259241;24484;63868;24471;29455;299626;58868;25427;306575;64515;25599;362485;114494;25649;81633 top2a;srebf1;slpi;serpina6;prkar2b;pparg;pir;pdlim1;nr1i3;nr1d2;igfbp3;hspd1;hspb1;gdf15;gadd45b;fzd1;cyp51;ckap2;cdc20;cd74;ccne2;ccna2;apoa2;acta2 TOP2A_10059;SREBF1_32750;SLPI_9890;SERPINA6_32325;PRKAR2B_33052;PPARG_32510;PIR_9487;PDLIM1_9452;NR1I3_32602;NR1D2_9358;IGFBP3_8881;HSPD1_8849;HSPB1_8847;GDF15_33113;GADD45B_8679;FZD1_8671;CYP51_8429;CKAP2_8324;CDC20_8255;CD74_8252;CCNE2_8227;CCNA2_8221;APOA2_33095;ACTA2_33040 25664(0.0441) 58.92815333333334 54.350300000000004 3.54778 27.514261723911787 57.848860229567094 25.20373587070432 37.28198916666667 37.574 1.51564 16.22488760930696 37.44348390050191 15.394433877124573 115.30641041666667 96.80000000000001 8.55785 86.71752317330201 108.55977925019961 79.07423820050575 54.9577;41.2009;53.7429;68.3847;108.746;60.1903;52.1607;67.1147;22.095;99.0234;50.946;34.4455;41.6322;21.3654;52.5718;25.231;75.1522;64.2131;101.569;94.9138;77.8893;52.8265;3.54778;90.3558 18.8326;31.4864;37.8192;36.9679;59.3814;43.9036;40.9644;47.2419;12.9529;42.5557;36.3081;26.6907;30.9494;17.8875;37.1918;13.6792;48.098;43.1133;51.5499;58.8146;49.2672;37.3288;1.51564;70.2676 218.525;60.0774;92.543;89.5095;147.467;101.057;74.9097;123.914;55.8619;102.838;85.0816;48.4857;63.3196;26.3528;89.36;131.659;171.379;125.437;453.17;118.773;185.461;90.0448;8.55785;103.57 15 9 15 78968;299270;24679;25664;363465;54133;65035;259241;63868;24471;29455;299626;58868;25599;25649 SREBF1_32750;SERPINA6_32325;PRKAR2B_33052;PPARG_32510;PIR_9487;PDLIM1_9452;NR1I3_32602;NR1D2_9358;HSPD1_8849;HSPB1_8847;GDF15_33113;GADD45B_8679;FZD1_8671;CD74_8252;APOA2_33095 52.841545333333336 52.1607 30.7709084477154 33.47886933333333 36.9679 16.71151468157188 82.80949666666667 89.36 39.58327987116197 41.2009;68.3847;108.746;60.1903;52.1607;67.1147;22.095;99.0234;34.4455;41.6322;21.3654;52.5718;25.231;94.9138;3.54778 31.4864;36.9679;59.3814;43.9036;40.9644;47.2419;12.9529;42.5557;26.6907;30.9494;17.8875;37.1918;13.6792;58.8146;1.51564 60.0774;89.5095;147.467;101.057;74.9097;123.914;55.8619;102.838;48.4857;63.3196;26.3528;89.36;131.659;118.773;8.55785 9 360243;84386;24484;25427;306575;64515;362485;114494;81633 TOP2A_10059;SLPI_9890;IGFBP3_8881;CYP51_8429;CKAP2_8324;CDC20_8255;CCNE2_8227;CCNA2_8221;ACTA2_33040 69.07249999999999 64.2131 18.282644048659982 43.62052222222222 43.1133 13.992344123196228 169.46793333333335 125.437 116.60868439794696 54.9577;53.7429;50.946;75.1522;64.2131;101.569;77.8893;52.8265;90.3558 18.8326;37.8192;36.3081;48.098;43.1133;51.5499;49.2672;37.3288;70.2676 218.525;92.543;85.0816;171.379;125.437;453.17;185.461;90.0448;103.57 0 Exp 2,8(0.34);Hill,1(0.05);Linear,8(0.34);Poly 2,5(0.21);Power,2(0.09) 1.8681012623028828 46.7498459815979 1.5124053955078125 5.015069484710693 0.7300280674493667 1.7201437950134277 47.920156027414286 69.93615063925239 30.790682189788143 43.773296143545195 80.61217543968093 150.00064539365243 UP 0.625 0.375 0.0 GO:0006639 6 acylglycerol metabolic process 23 26 4 4 2 4 2 2 94 24 2427 0.92789 0.25657 0.25657 7.69 25086;25649 cyp2e1;apoa2 CYP2E1_8421;APOA2_33095 5.71976 5.71976 3.54778 3.0716435732031164 5.457004183882375 3.049083961289479 2.8418050000000004 2.8418050000000004 1.51564 1.8754805289445153 2.6813718620882194 1.8617061075716432 12.182875 12.182875 8.55785 5.126559518941533 11.744336706681555 5.0889076265773125 0.5 5.71976 7.89174;3.54778 4.16797;1.51564 15.8079;8.55785 2 0 2 25086;25649 CYP2E1_8421;APOA2_33095 5.71976 5.71976 3.0716435732031164 2.8418050000000004 2.8418050000000004 1.8754805289445153 12.182875 12.182875 5.126559518941533 7.89174;3.54778 4.16797;1.51564 15.8079;8.55785 0 0 Exp 4,1(0.5);Hill,1(0.5) 1.6257029259753206 3.2572625875473022 1.5310101509094238 1.7262524366378784 0.13805714421295173 1.6286312937736511 1.4626791999999993 9.976840800000002 0.24252160000000078 5.4410884 5.077826 19.287923999999997 UP 1.0 0.0 0.0 GO:0045087 5 innate immune response 79 87 3 3 3 3 3 3 93 84 2367 0.58284 0.64579 1.0 3.45 29142;365813;84386 vnn1;trim59;slpi VNN1_10157;TRIM59_10085;SLPI_9890 43.5345 53.7429 20.7328 19.782822831183637 50.51130117698107 13.886483158874483 29.425233333333335 33.6269 16.8296 11.107714847048129 33.578349427781085 8.12990592262403 80.40326666666667 92.543 26.7838 48.69799076156361 95.52113375277975 35.99446154706764 20.7328;56.1278;53.7429 16.8296;33.6269;37.8192 26.7838;121.883;92.543 1 2 1 29142 VNN1_10157 20.7328 20.7328 16.8296 16.8296 26.7838 26.7838 20.7328 16.8296 26.7838 2 365813;84386 TRIM59_10085;SLPI_9890 54.93535 54.93535 1.6863789624516887 35.72305 35.72305 2.964403758768402 107.213 107.213 20.746512960013373 56.1278;53.7429 33.6269;37.8192 121.883;92.543 0 Exp 2,1(0.34);Linear,2(0.67) 2.294272508199314 7.851356625556946 1.528815746307373 4.608505725860596 1.7270763587550866 1.714035153388977 21.14812854964751 65.9208714503525 16.85567070556465 41.99479596110202 25.296302439308676 135.51023089402466 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0070925 6 organelle assembly 79 80 3 2 3 3 2 2 94 78 2373 0.41187 0.81348 0.76801 2.5 362094;64515 mrps2;cdc20 MRPS2_9250;CDC20_8255 82.4424 82.4424 63.3158 27.049097122085218 77.1575286235586 25.99603670156158 48.4464 48.4464 45.3429 4.389011790824996 47.58887182893008 4.218141222344576 282.2075 282.2075 111.245 241.77748615721032 234.9688468836666 232.36473939909527 63.3158;101.569 45.3429;51.5499 111.245;453.17 1 1 1 362094 MRPS2_9250 63.3158 63.3158 45.3429 45.3429 111.245 111.245 63.3158 45.3429 111.245 1 64515 CDC20_8255 101.569 101.569 51.5499 51.5499 453.17 453.17 101.569 51.5499 453.17 0 Exp 2,2(1) 1.5285348551372364 3.0570701360702515 1.5277283191680908 1.5293418169021606 0.0011409151891899015 1.5285350680351257 44.95426400000001 119.930536 42.36354 54.529259999999994 -52.87900000000002 617.294 CONFLICT 0.5 0.5 0.0 GO:0071398 6 cellular response to fatty acid 37 38 3 3 3 3 3 3 93 35 2416 0.94747 0.17049 0.17049 7.89 78968;25664;24471 srebf1;pparg;hspb1 SREBF1_32750;PPARG_32510;HSPB1_8847 25664(0.0441) 47.67446666666667 41.6322 41.2009 10.841174656988642 48.29975203227476 11.118783362146768 35.446466666666666 31.4864 30.9494 7.329012239949738 35.92461895926821 7.464200737774998 74.818 63.3196 60.0774 22.781391659861352 75.97186883845357 23.503613060914436 0.5 41.41655 41.2009;60.1903;41.6322 31.4864;43.9036;30.9494 60.0774;101.057;63.3196 3 0 3 78968;25664;24471 SREBF1_32750;PPARG_32510;HSPB1_8847 47.67446666666667 41.6322 10.841174656988642 35.446466666666666 31.4864 7.329012239949738 74.818 63.3196 22.781391659861352 41.2009;60.1903;41.6322 31.4864;43.9036;30.9494 60.0774;101.057;63.3196 0 0 Exp 2,2(0.67);Linear,1(0.34) 1.7525676228488996 5.283383131027222 1.5239794254302979 1.912555456161499 0.2079875982636994 1.8468482494354248 35.40652265784012 59.942410675493214 27.152908574993724 43.74002475833961 49.038428489622916 100.59757151037708 UP 1.0 0.0 0.0 GO:0080134 5 regulation of response to stress 340 358 14 14 11 14 11 11 85 347 2104 0.2828 0.8133 0.54988 3.07 29142;84386;309607;25664;259241;63868;24471;299626;58868;25599;81633 vnn1;slpi;rt1-ce5;pparg;nr1d2;hspd1;hspb1;gadd45b;fzd1;cd74;acta2 VNN1_10157;SLPI_9890;RT1-CE5_32445;PPARG_32510;NR1D2_9358;HSPD1_8849;HSPB1_8847;GADD45B_8679;FZD1_8671;CD74_8252;ACTA2_33040 25664(0.0441) 57.0600090909091 53.7429 20.7328 27.259111353213765 58.97348766936868 24.105156089164453 36.84469090909091 37.1918 13.6792 16.921992010071076 38.92492664043549 15.559082904635595 93.29210000000002 101.057 26.7838 35.6334355242095 97.08937131974442 30.519347206980033 20.7328;53.7429;54.8206;60.1903;99.0234;34.4455;41.6322;52.5718;25.231;94.9138;90.3558 16.8296;37.8192;26.5902;43.9036;42.5557;26.6907;30.9494;37.1918;13.6792;58.8146;70.2676 26.7838;92.543;147.824;101.057;102.838;48.4857;63.3196;89.36;131.659;118.773;103.57 8 3 8 29142;25664;259241;63868;24471;299626;58868;25599 VNN1_10157;PPARG_32510;NR1D2_9358;HSPD1_8849;HSPB1_8847;GADD45B_8679;FZD1_8671;CD74_8252 53.5926 47.102000000000004 29.784416474727195 33.826825 34.0706 14.964161543286393 85.2845125 95.2085 36.064468297735786 20.7328;60.1903;99.0234;34.4455;41.6322;52.5718;25.231;94.9138 16.8296;43.9036;42.5557;26.6907;30.9494;37.1918;13.6792;58.8146 26.7838;101.057;102.838;48.4857;63.3196;89.36;131.659;118.773 3 84386;309607;81633 SLPI_9890;RT1-CE5_32445;ACTA2_33040 66.30643333333335 54.8206 20.834331933693804 44.89233333333334 37.8192 22.68150632240577 114.64566666666667 103.57 29.25747826340018 53.7429;54.8206;90.3558 37.8192;26.5902;70.2676 92.543;147.824;103.57 0 Exp 2,3(0.28);Linear,4(0.37);Poly 2,3(0.28);Power,1(0.1) 1.898638999172662 22.247297883033752 1.5124053955078125 4.608505725860596 0.9227835016811572 1.6577342748641968 40.950903711348246 73.16911447046994 26.844432683865133 46.84494913431668 72.23408528861422 114.35011471138576 UP 0.7272727272727273 0.2727272727272727 0.0 GO:1902176 8 negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway 9 9 2 2 2 2 2 2 94 7 2444 0.9963 0.042588 0.042588 22.22 29142;24471 vnn1;hspb1 VNN1_10157;HSPB1_8847 31.182499999999997 31.182499999999997 20.7328 14.778107462730137 35.644314975247525 13.363265859561187 23.889499999999998 23.889499999999998 16.8296 9.984206328997834 26.903937499999998 9.02832814740292 45.0517 45.0517 26.7838 25.83471193607547 52.85173155940594 23.36132179831746 0.0 20.7328 0.0 20.7328 20.7328;41.6322 16.8296;30.9494 26.7838;63.3196 2 0 2 29142;24471 VNN1_10157;HSPB1_8847 31.182499999999997 31.182499999999997 14.778107462730137 23.889499999999998 23.889499999999998 9.984206328997834 45.0517 45.0517 25.83471193607547 20.7328;41.6322 16.8296;30.9494 26.7838;63.3196 0 0 Linear,2(1) 2.9173979386293487 6.4553539752960205 1.8468482494354248 4.608505725860596 1.9527867288947665 3.2276769876480103 10.701088000000006 51.66391199999999 10.052095999999999 37.726904 9.246615999999996 80.856784 UP 1.0 0.0 0.0 GO:0044238 3 primary metabolic process 1157 1278 72 70 62 71 60 60 36 1218 1233 0.99503 0.0089662 0.016362 4.69 286954;365813;360243;360268;64305;78968;24950;299270;293820;24679;298490;25664;313245;296371;65035;362094;291234;316273;315994;293502;24484;25685;63868;364975;65030;25315;171142;291075;29740;64526;117543;114027;25427;50549;266682;65210;25086;24303;499353;171521;29277;24894;311849;25413;297594;64515;25599;362485;114494;25612;25649;502970;65155;24763;50681;681337;314304;192272;50559;170465 ugt2b1;trim59;top2a;sult1e1;sult1b1;srebf1;srd5a1;serpina6;psat1;prkar2b;ppcs;pparg;polr1e;pltp;nr1i3;mrps2;mki67;mcm3;mapkapk3;kif22;igfbp3;igfbp1;hspd1;gcdh;ephx2;ephx1;ehhadh;eci2;eci1;ech1;decr1;dao;cyp51;cyp4a1;cyp3a2;cyp2j4;cyp2e1;cyp2d3;cyp2c24;cyp2c13;cyp2c11;cyp2a1;crat;cpt2;cdca3;cdc20;cd74;ccne2;ccna2;asns;apoa2;angptl3;alas1;acsm3;acox1;acot4;acot3;acot2;acot1;acaa2 UGT2B10_33303,UGT2B1_33224;TRIM59_10085;TOP2A_10059;SULT1E1_32446;SULT1B1_32942;SREBF1_32750;SRD5A1_32503;SERPINA6_32325;PSAT1_9583;PRKAR2B_33052;PPCS_9540;PPARG_32510;POLR1E_9523;PLTP_32412;NR1I3_32602;MRPS2_9250;MKI67_9232;MCM3_9207;MAPKAPK3_9194;KIF22_8963;IGFBP3_8881;IGFBP1_32306;HSPD1_8849;GCDH_8693;EPHX2_33282;EPHX1_8567;EHHADH_8534;ECI2_8521;ECI1_8520;ECH1_8516;DECR1_8458;DAO_8437;CYP51_8429;CYP4A1_33111;CYP3A2_32374;CYP2J4_32580;CYP2E1_8421;CYP2D3_8420;CYP2C24_32875;CYP2C13_8419;CYP2C11_32593;CYP2A1_32717;CRAT_8375;CPT2_8374;CDCA3_8260;CDC20_8255;CD74_8252;CCNE2_8227;CCNA2_8221;ASNS_8091;APOA2_33095;ANGPTL3_8045;ALAS1_8018;ACSM3_7976;ACOX1_7973;ACOT4_7971;ACOT3_7970;ACOT2_7969;ACOT1_7968;ACAA2_7955 25664(0.0441) 42.31222166666668 32.615449999999996 3.54778 30.24302847730421 43.48862579309435 30.188322371546356 27.270366749999997 24.714199999999998 1.51564 18.06074611591899 27.915451287347654 18.187939499928444 84.50415500000001 48.4269 8.55785 91.72540713298906 82.52270323033834 86.0926295295593 12.54415;56.1278;54.9577;59.2729;15.4629;41.2009;29.2087;68.3847;26.3316;108.746;15.1091;60.1903;73.982;87.0256;22.095;63.3158;49.7822;54.0045;104.193;73.9175;50.946;98.8371;34.4455;15.9021;6.44145;34.0134;7.29984;8.72912;11.7653;9.87438;21.6199;6.1336;75.1522;23.208;23.2485;16.3155;7.89174;12.8059;58.9435;104.635;54.426;9.37187;8.98517;31.2175;46.7245;101.569;94.9138;77.8893;52.8265;28.1893;3.54778;58.0729;27.1843;52.2057;23.8014;12.3157;30.8838;13.6362;28.5134;78.3988 7.348245;33.6269;18.8326;45.3114;7.69418;31.4864;22.9308;36.9679;20.9188;59.3814;7.94061;43.9036;47.589;56.6266;12.9529;45.3429;35.6665;33.259;59.1667;47.5608;36.3081;57.328;26.6907;10.4227;2.66377;26.1579;5.26587;5.10151;8.40998;6.59127;17.4928;2.43617;48.098;18.863;18.6955;8.2378;4.16797;8.8664;48.1505;49.2461;43.9518;4.95906;1.97988;24.8356;21.1123;51.5499;58.8146;49.2672;37.3288;23.1774;1.51564;40.0757;21.5215;42.2655;19.0993;6.70485;24.6874;11.3249;24.741;43.6084 25.495849999999997;121.883;218.525;91.5578;35.0879;60.0774;39.9852;89.5095;35.2954;147.467;30.6311;101.057;165.722;104.563;55.8619;111.245;82.1147;111.753;434.985;165.416;85.0816;357.409;48.4857;31.2818;17.3473;48.3681;11.8779;17.7951;18.8402;19.44;28.0829;16.2027;171.379;29.9853;30.5145;36.8422;15.8079;22.6004;80.4167;108.327;74.8861;19.1079;31.3726;42.0237;127.486;453.17;118.773;185.461;90.0448;35.9474;8.55785;105.112;36.6615;71.1126;31.3543;24.3993;41.2585;16.9658;33.4642;98.7727 47 14 46 286954;360268;64305;78968;299270;293820;24679;298490;25664;313245;296371;65035;362094;25685;63868;364975;65030;25315;171142;291075;29740;64526;117543;114027;50549;266682;65210;25086;24303;499353;171521;29277;24894;311849;25413;25599;25612;25649;502970;65155;24763;50681;681337;314304;192272;50559 UGT2B10_33303,UGT2B1_33224;SULT1E1_32446;SULT1B1_32942;SREBF1_32750;SERPINA6_32325;PSAT1_9583;PRKAR2B_33052;PPCS_9540;PPARG_32510;POLR1E_9523;PLTP_32412;NR1I3_32602;MRPS2_9250;IGFBP1_32306;HSPD1_8849;GCDH_8693;EPHX2_33282;EPHX1_8567;EHHADH_8534;ECI2_8521;ECI1_8520;ECH1_8516;DECR1_8458;DAO_8437;CYP4A1_33111;CYP3A2_32374;CYP2J4_32580;CYP2E1_8421;CYP2D3_8420;CYP2C24_32875;CYP2C13_8419;CYP2C11_32593;CYP2A1_32717;CRAT_8375;CPT2_8374;CD74_8252;ASNS_8091;APOA2_33095;ANGPTL3_8045;ALAS1_8018;ACSM3_7976;ACOX1_7973;ACOT4_7971;ACOT3_7970;ACOT2_7969;ACOT1_7968 35.50077391304348 25.0665 29.41055097954923 23.867521847826087 20.009050000000002 18.288958341390735 58.352006521739135 35.6214 59.203962457791825 12.54415;59.2729;15.4629;41.2009;68.3847;26.3316;108.746;15.1091;60.1903;73.982;87.0256;22.095;63.3158;98.8371;34.4455;15.9021;6.44145;34.0134;7.29984;8.72912;11.7653;9.87438;21.6199;6.1336;23.208;23.2485;16.3155;7.89174;12.8059;58.9435;104.635;54.426;9.37187;8.98517;31.2175;94.9138;28.1893;3.54778;58.0729;27.1843;52.2057;23.8014;12.3157;30.8838;13.6362;28.5134 7.348245;45.3114;7.69418;31.4864;36.9679;20.9188;59.3814;7.94061;43.9036;47.589;56.6266;12.9529;45.3429;57.328;26.6907;10.4227;2.66377;26.1579;5.26587;5.10151;8.40998;6.59127;17.4928;2.43617;18.863;18.6955;8.2378;4.16797;8.8664;48.1505;49.2461;43.9518;4.95906;1.97988;24.8356;58.8146;23.1774;1.51564;40.0757;21.5215;42.2655;19.0993;6.70485;24.6874;11.3249;24.741 25.495849999999997;91.5578;35.0879;60.0774;89.5095;35.2954;147.467;30.6311;101.057;165.722;104.563;55.8619;111.245;357.409;48.4857;31.2818;17.3473;48.3681;11.8779;17.7951;18.8402;19.44;28.0829;16.2027;29.9853;30.5145;36.8422;15.8079;22.6004;80.4167;108.327;74.8861;19.1079;31.3726;42.0237;118.773;35.9474;8.55785;105.112;36.6615;71.1126;31.3543;24.3993;41.2585;16.9658;33.4642 14 365813;360243;24950;291234;316273;315994;293502;24484;25427;297594;64515;362485;114494;170465 TRIM59_10085;TOP2A_10059;SRD5A1_32503;MKI67_9232;MCM3_9207;MAPKAPK3_9194;KIF22_8963;IGFBP3_8881;CYP51_8429;CDCA3_8260;CDC20_8255;CCNE2_8227;CCNA2_8221;ACAA2_7955 64.69269285714286 55.54275 21.29116465887867 38.45114285714286 36.81845 12.123041546049935 170.43264285714287 124.6845 125.21878743599578 56.1278;54.9577;29.2087;49.7822;54.0045;104.193;73.9175;50.946;75.1522;46.7245;101.569;77.8893;52.8265;78.3988 33.6269;18.8326;22.9308;35.6665;33.259;59.1667;47.5608;36.3081;48.098;21.1123;51.5499;49.2672;37.3288;43.6084 121.883;218.525;39.9852;82.1147;111.753;434.985;165.416;85.0816;171.379;127.486;453.17;185.461;90.0448;98.7727 0 Exp 2,18(0.3);Exp 4,6(0.1);Hill,8(0.14);Linear,18(0.3);Poly 2,9(0.15);Power,2(0.04) 2.1245638178985042 177.06005036830902 1.5084086656570435 50.888092041015625 6.283441314059734 1.8691840171813965 34.65967961874358 49.964763714589765 22.700367446767082 31.840366053232927 61.294424682322784 107.71388531767724 UP 0.7666666666666667 0.23333333333333334 0.0 GO:0015746 9 citrate transport 2 2 1 1 1 1 1 1 95 1 2450 0.99859 0.073976 0.073976 50.0 503568 slc13a4 SLC13A4_9836 65.6237 65.6237 65.6237 65.6237 42.6891 42.6891 42.6891 42.6891 135.744 135.744 135.744 135.744 0.0 65.6237 0.0 65.6237 65.6237 42.6891 135.744 0 1 0 1 503568 SLC13A4_9836 65.6237 65.6237 42.6891 42.6891 135.744 135.744 65.6237 42.6891 135.744 0 Exp 2,1(1) 1.5349997282028198 1.5349997282028198 1.5349997282028198 1.5349997282028198 0.0 1.5349997282028198 65.6237 65.6237 42.6891 42.6891 135.744 135.744 DOWN 0.0 1.0 0.0 GO:0001818 6 negative regulation of cytokine production 68 69 5 5 4 5 4 4 92 65 2386 0.88396 0.26109 0.32912 5.8 309607;25664;24614;25649 rt1-ce5;pparg;orm1;apoa2 RT1-CE5_32445;PPARG_32510;ORM1_9400;APOA2_33095 25664(0.0441) 35.702645 39.536249999999995 3.54778 26.647053339311277 37.20593787072777 26.085038852357112 22.930685 23.15175 1.51564 17.532930276318137 24.588219619622425 17.572751157915135 72.1992125 66.2075 8.55785 63.95338938930935 72.43646331496947 61.012431357390845 2.5 57.505449999999996 54.8206;60.1903;24.2519;3.54778 26.5902;43.9036;19.7133;1.51564 147.824;101.057;31.358;8.55785 3 1 3 25664;24614;25649 PPARG_32510;ORM1_9400;APOA2_33095 29.329993333333334 24.2519 28.660670646621885 21.71084666666667 19.7133 21.264464083407635 46.99095 31.358 48.19040394059279 60.1903;24.2519;3.54778 43.9036;19.7133;1.51564 101.057;31.358;8.55785 1 309607 RT1-CE5_32445 54.8206 54.8206 26.5902 26.5902 147.824 147.824 54.8206 26.5902 147.824 0 Exp 2,3(0.75);Hill,1(0.25) 2.0431041941822636 8.682735204696655 1.5239794254302979 3.5849626064300537 0.9522520266588724 1.7868965864181519 9.588532727474956 61.81675727252504 5.748413329208223 40.112956670791775 9.524890898476855 134.87353410152318 UP 0.75 0.25 0.0 GO:0030154 4 cell differentiation 405 432 18 18 13 18 13 13 83 419 2032 0.2237 0.85383 0.4082 3.01 360243;25123;64305;78968;24950;25664;363465;65035;259241;25626;24484;58868;155423 top2a;tagln;sult1b1;srebf1;srd5a1;pparg;pir;nr1i3;nr1d2;krt8;igfbp3;fzd1;anxa7 TOP2A_10059;TAGLN_9981;SULT1B1_32942;SREBF1_32750;SRD5A1_32503;PPARG_32510;PIR_9487;NR1I3_32602;NR1D2_9358;KRT8_8978;IGFBP3_8881;FZD1_8671;ANXA7_8051 25664(0.0441) 48.469423076923086 50.946 15.4629 22.722301618936456 45.96722989689354 21.943289851735717 30.393013846153845 35.0852 7.69418 13.479793997900178 29.677581407131207 14.342806644473399 95.68239230769231 85.0816 35.0879 50.594256024464876 90.77106687986837 49.379018341991674 54.9577;45.9044;15.4629;41.2009;29.2087;60.1903;52.1607;22.095;99.0234;68.9539;50.946;25.231;64.7676 18.8326;35.0852;7.69418;31.4864;22.9308;43.9036;40.9644;12.9529;42.5557;45.3374;36.3081;13.6792;43.3787 218.525;67.7714;35.0879;60.0774;39.9852;101.057;74.9097;55.8619;102.838;143.578;85.0816;131.659;127.439 10 3 10 25123;64305;78968;25664;363465;65035;259241;25626;58868;155423 TAGLN_9981;SULT1B1_32942;SREBF1_32750;PPARG_32510;PIR_9487;NR1I3_32602;NR1D2_9358;KRT8_8978;FZD1_8671;ANXA7_8051 49.499010000000006 49.03255 25.311018184640897 31.703768000000004 38.0248 14.67787958575064 90.02793 87.98335 36.655688021522955 45.9044;15.4629;41.2009;60.1903;52.1607;22.095;99.0234;68.9539;25.231;64.7676 35.0852;7.69418;31.4864;43.9036;40.9644;12.9529;42.5557;45.3374;13.6792;43.3787 67.7714;35.0879;60.0774;101.057;74.9097;55.8619;102.838;143.578;131.659;127.439 3 360243;24950;24484 TOP2A_10059;SRD5A1_32503;IGFBP3_8881 45.03746666666666 50.946 13.854090546237018 26.02383333333334 22.9308 9.139114643297408 114.5306 85.0816 92.8415195198786 54.9577;29.2087;50.946 18.8326;22.9308;36.3081 218.525;39.9852;85.0816 0 Exp 2,5(0.39);Exp 4,1(0.08);Linear,4(0.31);Poly 2,2(0.16);Power,1(0.08) 1.8473292087534463 24.42574369907379 1.5124053955078125 2.7270524501800537 0.380357967623225 1.8061060905456543 36.117439213544436 60.82140694030172 23.065314357957167 37.72071333435052 68.17904143794493 123.18574317743966 UP 0.7692307692307693 0.23076923076923078 0.0 GO:0006631 6 fatty acid metabolic process 129 145 32 32 29 32 29 29 67 116 2335 1.0 6.565E-15 6.565E-15 20.0 24679;25664;364975;65030;25315;171142;291075;29740;64526;117543;50549;65210;25086;24303;499353;171521;29277;24894;311849;25413;25599;502970;24763;50681;681337;314304;192272;50559;170465 prkar2b;pparg;gcdh;ephx2;ephx1;ehhadh;eci2;eci1;ech1;decr1;cyp4a1;cyp2j4;cyp2e1;cyp2d3;cyp2c24;cyp2c13;cyp2c11;cyp2a1;crat;cpt2;cd74;angptl3;acsm3;acox1;acot4;acot3;acot2;acot1;acaa2 PRKAR2B_33052;PPARG_32510;GCDH_8693;EPHX2_33282;EPHX1_8567;EHHADH_8534;ECI2_8521;ECI1_8520;ECH1_8516;DECR1_8458;CYP4A1_33111;CYP2J4_32580;CYP2E1_8421;CYP2D3_8420;CYP2C24_32875;CYP2C13_8419;CYP2C11_32593;CYP2A1_32717;CRAT_8375;CPT2_8374;CD74_8252;ANGPTL3_8045;ACSM3_7976;ACOX1_7973;ACOT4_7971;ACOT3_7970;ACOT2_7969;ACOT1_7968;ACAA2_7955 25664(0.0441) 34.65943689655172 23.208 6.44145 30.693583441084474 38.001792796112866 32.36272764709365 23.10243310344828 18.863 1.97988 18.519164519747044 24.76034523028483 19.524986904571048 49.797913793103454 31.3726 11.8779 37.91017888840037 54.884192669321756 39.27103197502292 6.5 10.81984 13.5 22.41395 108.746;60.1903;15.9021;6.44145;34.0134;7.29984;8.72912;11.7653;9.87438;21.6199;23.208;16.3155;7.89174;12.8059;58.9435;104.635;54.426;9.37187;8.98517;31.2175;94.9138;58.0729;52.2057;23.8014;12.3157;30.8838;13.6362;28.5134;78.3988 59.3814;43.9036;10.4227;2.66377;26.1579;5.26587;5.10151;8.40998;6.59127;17.4928;18.863;8.2378;4.16797;8.8664;48.1505;49.2461;43.9518;4.95906;1.97988;24.8356;58.8146;40.0757;42.2655;19.0993;6.70485;24.6874;11.3249;24.741;43.6084 147.467;101.057;31.2818;17.3473;48.3681;11.8779;17.7951;18.8402;19.44;28.0829;29.9853;36.8422;15.8079;22.6004;80.4167;108.327;74.8861;19.1079;31.3726;42.0237;118.773;105.112;71.1126;31.3543;24.3993;41.2585;16.9658;33.4642;98.7727 28 1 28 24679;25664;364975;65030;25315;171142;291075;29740;64526;117543;50549;65210;25086;24303;499353;171521;29277;24894;311849;25413;25599;502970;24763;50681;681337;314304;192272;50559 PRKAR2B_33052;PPARG_32510;GCDH_8693;EPHX2_33282;EPHX1_8567;EHHADH_8534;ECI2_8521;ECI1_8520;ECH1_8516;DECR1_8458;CYP4A1_33111;CYP2J4_32580;CYP2E1_8421;CYP2D3_8420;CYP2C24_32875;CYP2C13_8419;CYP2C11_32593;CYP2A1_32717;CRAT_8375;CPT2_8374;CD74_8252;ANGPTL3_8045;ACSM3_7976;ACOX1_7973;ACOT4_7971;ACOT3_7970;ACOT2_7969;ACOT1_7968 33.097316785714284 22.41395 30.059959698662283 22.370077142857145 18.1779 18.42638243551687 48.048814285714286 31.36345 37.3952339582418 108.746;60.1903;15.9021;6.44145;34.0134;7.29984;8.72912;11.7653;9.87438;21.6199;23.208;16.3155;7.89174;12.8059;58.9435;104.635;54.426;9.37187;8.98517;31.2175;94.9138;58.0729;52.2057;23.8014;12.3157;30.8838;13.6362;28.5134 59.3814;43.9036;10.4227;2.66377;26.1579;5.26587;5.10151;8.40998;6.59127;17.4928;18.863;8.2378;4.16797;8.8664;48.1505;49.2461;43.9518;4.95906;1.97988;24.8356;58.8146;40.0757;42.2655;19.0993;6.70485;24.6874;11.3249;24.741 147.467;101.057;31.2818;17.3473;48.3681;11.8779;17.7951;18.8402;19.44;28.0829;29.9853;36.8422;15.8079;22.6004;80.4167;108.327;74.8861;19.1079;31.3726;42.0237;118.773;105.112;71.1126;31.3543;24.3993;41.2585;16.9658;33.4642 1 170465 ACAA2_7955 78.3988 78.3988 43.6084 43.6084 98.7727 98.7727 78.3988 43.6084 98.7727 0 Exp 2,8(0.28);Exp 4,4(0.14);Hill,5(0.18);Linear,5(0.18);Poly 2,5(0.18);Power,2(0.07) 2.3811066411482167 113.97413980960846 1.5239794254302979 50.888092041015625 9.066759445207033 1.940477728843689 23.488112396914552 45.8307613961889 16.36214496767653 29.842721239220015 36.00001655459672 63.59581103161016 UP 0.9655172413793104 0.034482758620689655 0.0 GO:0009617 5 response to bacterium 110 127 6 6 4 4 3 3 93 124 2327 0.2841 0.8679 0.62885 2.36 84386;25211;25086 slpi;lyz2;cyp2e1 SLPI_9890;LYZ2_32611;CYP2E1_8421 46.48678 53.7429 7.89174 35.527146640438204 53.63872408924556 31.589370669946025 30.40915666666667 37.8192 4.16797 23.432035540230665 35.29018655628555 20.51539109998453 97.8233 92.543 15.8079 84.7789674498929 112.86801727148462 79.12803978748246 53.7429;77.8257;7.89174 37.8192;49.2403;4.16797 92.543;185.119;15.8079 1 2 1 25086 CYP2E1_8421 7.89174 7.89174 4.16797 4.16797 15.8079 15.8079 7.89174 4.16797 15.8079 2 84386;25211 SLPI_9890;LYZ2_32611 65.7843 65.7843 17.029111189959345 43.52975 43.52975 8.075937258609672 138.83100000000002 138.83100000000002 65.46111737512572 53.7429;77.8257 37.8192;49.2403 92.543;185.119 0 Exp 4,1(0.34);Linear,2(0.67) 1.660166491161356 4.988686561584473 1.5310101509094238 1.7436412572860718 0.11517136530663298 1.714035153388977 6.284028954263228 86.68953104573677 3.8933122941130804 56.925001039220255 1.886867029524197 193.75973297047585 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0071392 6 cellular response to estradiol stimulus 25 26 3 3 3 3 3 3 93 23 2428 0.98502 0.07211 0.07211 11.54 24950;24484;114494 srd5a1;igfbp3;ccna2 SRD5A1_32503;IGFBP3_8881;CCNA2_8221 44.32706666666667 50.946 29.2087 13.126607637288968 44.748406877382465 12.835813868927586 32.189233333333334 36.3081 22.9308 8.034263996367907 32.45244836404067 7.860260388766953 71.70386666666667 85.0816 39.9852 27.581038774733106 72.54751124523507 26.93959759697895 0.5 40.077349999999996 1.5 51.886250000000004 29.2087;50.946;52.8265 22.9308;36.3081;37.3288 39.9852;85.0816;90.0448 0 3 0 3 24950;24484;114494 SRD5A1_32503;IGFBP3_8881;CCNA2_8221 44.32706666666667 50.946 13.126607637288968 32.189233333333334 36.3081 8.034263996367907 71.70386666666667 85.0816 27.581038774733106 29.2087;50.946;52.8265 22.9308;36.3081;37.3288 39.9852;85.0816;90.0448 0 Linear,3(1) 1.990529337274805 6.014885306358337 1.7380040884017944 2.3255980014801025 0.29745199932966704 1.9512832164764404 29.4729117789133 59.181221554420034 23.097607750488034 41.28085891617863 40.492983150868156 102.91475018246518 DOWN 0.0 1.0 0.0 GO:0051173 6 positive regulation of nitrogen compound metabolic process 649 698 25 25 18 24 18 18 78 680 1771 0.030922 0.983 0.061328 2.58 360243;78968;25664;54133;65035;259241;24484;63868;24471;29455;299626;58868;306575;64515;25599;114494;25649;81633 top2a;srebf1;pparg;pdlim1;nr1i3;nr1d2;igfbp3;hspd1;hspb1;gdf15;gadd45b;fzd1;ckap2;cdc20;cd74;ccna2;apoa2;acta2 TOP2A_10059;SREBF1_32750;PPARG_32510;PDLIM1_9452;NR1I3_32602;NR1D2_9358;IGFBP3_8881;HSPD1_8849;HSPB1_8847;GDF15_33113;GADD45B_8679;FZD1_8671;CKAP2_8324;CDC20_8255;CD74_8252;CCNA2_8221;APOA2_33095;ACTA2_33040 25664(0.0441) 54.34443777777778 52.69915 3.54778 28.45732978907266 55.36166118810408 26.835567929902286 34.57053555555555 36.74995 1.51564 17.421052367224526 36.09387584498141 17.01393536498227 111.44914722222224 95.5509 8.55785 97.24889155152128 109.67562829600372 88.72178565566257 54.9577;41.2009;60.1903;67.1147;22.095;99.0234;50.946;34.4455;41.6322;21.3654;52.5718;25.231;64.2131;101.569;94.9138;52.8265;3.54778;90.3558 18.8326;31.4864;43.9036;47.2419;12.9529;42.5557;36.3081;26.6907;30.9494;17.8875;37.1918;13.6792;43.1133;51.5499;58.8146;37.3288;1.51564;70.2676 218.525;60.0774;101.057;123.914;55.8619;102.838;85.0816;48.4857;63.3196;26.3528;89.36;131.659;125.437;453.17;118.773;90.0448;8.55785;103.57 12 6 12 78968;25664;54133;65035;259241;63868;24471;29455;299626;58868;25599;25649 SREBF1_32750;PPARG_32510;PDLIM1_9452;NR1I3_32602;NR1D2_9358;HSPD1_8849;HSPB1_8847;GDF15_33113;GADD45B_8679;FZD1_8671;CD74_8252;APOA2_33095 46.944314999999996 41.41655 29.343102221162802 30.40577833333333 31.2179 16.67161949517248 77.52135416666667 76.3398 39.671654241097734 41.2009;60.1903;67.1147;22.095;99.0234;34.4455;41.6322;21.3654;52.5718;25.231;94.9138;3.54778 31.4864;43.9036;47.2419;12.9529;42.5557;26.6907;30.9494;17.8875;37.1918;13.6792;58.8146;1.51564 60.0774;101.057;123.914;55.8619;102.838;48.4857;63.3196;26.3528;89.36;131.659;118.773;8.55785 6 360243;24484;306575;64515;114494;81633 TOP2A_10059;IGFBP3_8881;CKAP2_8324;CDC20_8255;CCNA2_8221;ACTA2_33040 69.14468333333333 59.5854 21.560677049612 42.90005 40.221050000000005 17.190596001622502 179.30473333333336 114.5035 142.8448323777751 54.9577;50.946;64.2131;101.569;52.8265;90.3558 18.8326;36.3081;43.1133;51.5499;37.3288;70.2676 218.525;85.0816;125.437;453.17;90.0448;103.57 0 Exp 2,7(0.39);Hill,1(0.06);Linear,5(0.28);Poly 2,4(0.23);Power,1(0.06) 1.923769813566266 36.46477460861206 1.5124053955078125 5.015069484710693 0.8312042237963826 1.7321282625198364 41.197822143811834 67.49105341174372 26.52241996956556 42.61865114154557 66.52245144530438 156.37584299914005 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0051241 5 negative regulation of multicellular organismal process 326 344 14 13 10 13 9 9 87 335 2116 0.1443 0.91873 0.28598 2.62 309607;25664;24614;102551184;29455;25427;25599;25649;114628 rt1-ce5;pparg;orm1;loc102551184;gdf15;cyp51;cd74;apoa2;abcg5 RT1-CE5_32445;PPARG_32510;ORM1_9400;HIST1H4A_32934;GDF15_33113;CYP51_8429;CD74_8252;APOA2_33095;ABCG5_7947 25664(0.0441) 47.29824222222222 54.8206 3.54778 28.95380603504563 47.46820592514282 30.12923729941913 31.21549333333333 26.5902 1.51564 17.85725199253513 31.210734125277003 18.650569551360658 84.62628333333333 101.057 8.55785 57.66011506291633 79.47783155610223 52.178092363732596 54.8206;60.1903;24.2519;58.3303;21.3654;75.1522;94.9138;3.54778;33.1119 26.5902;43.9036;19.7133;40.2068;17.8875;48.098;58.8146;1.51564;24.2098 147.824;101.057;31.358;105.902;26.3528;171.379;118.773;8.55785;50.4329 5 4 5 25664;24614;29455;25599;25649 PPARG_32510;ORM1_9400;GDF15_33113;CD74_8252;APOA2_33095 40.853836 24.2519 36.54977352410654 28.366927999999994 19.7133 22.771386997082985 57.219730000000006 31.358 49.24450806967716 60.1903;24.2519;21.3654;94.9138;3.54778 43.9036;19.7133;17.8875;58.8146;1.51564 101.057;31.358;26.3528;118.773;8.55785 4 309607;102551184;25427;114628 RT1-CE5_32445;HIST1H4A_32934;CYP51_8429;ABCG5_7947 55.35375 56.575450000000004 17.2802643946787 34.7762 33.3985 11.337565531747387 118.88447500000001 126.863 53.06390499296577 54.8206;58.3303;75.1522;33.1119 26.5902;40.2068;48.098;24.2098 147.824;105.902;171.379;50.4329 0 Exp 2,5(0.56);Hill,1(0.12);Linear,2(0.23);Poly 2,1(0.12) 2.1524917664325205 21.176559686660767 1.5239794254302979 5.015069484710693 1.1968436622117646 1.7262524366378784 28.38175561265908 66.21472883178537 19.548755364877046 42.88223130178962 46.955008158894664 122.29755850777201 CONFLICT 0.5555555555555556 0.4444444444444444 0.0 GO:0032869 7 cellular response to insulin stimulus 59 62 6 6 4 6 4 4 92 58 2393 0.91822 0.2037 0.29337 6.45 78968;24950;25664;65155 srebf1;srd5a1;pparg;alas1 SREBF1_32750;SRD5A1_32503;PPARG_32510;ALAS1_8018 25664(0.0441) 39.44605 35.2048 27.1843 15.149887289679754 43.22782745873053 15.101295693418477 29.960575 27.2086 21.5215 10.285455936863787 32.56475025575447 10.208291792541633 59.445274999999995 50.0313 36.6615 29.60703836222901 66.51536007517632 29.89382979177217 2.5 50.6956 41.2009;29.2087;60.1903;27.1843 31.4864;22.9308;43.9036;21.5215 60.0774;39.9852;101.057;36.6615 3 1 3 78968;25664;65155 SREBF1_32750;PPARG_32510;ALAS1_8018 42.8585 41.2009 16.56531730212252 32.30383333333333 31.4864 11.213418214056485 65.93196666666667 60.0774 32.594509786209876 41.2009;60.1903;27.1843 31.4864;43.9036;21.5215 60.0774;101.057;36.6615 1 24950 SRD5A1_32503 29.2087 29.2087 22.9308 22.9308 39.9852 39.9852 29.2087 22.9308 39.9852 0 Exp 2,2(0.5);Linear,2(0.5) 1.798412584281169 7.227081298828125 1.5239794254302979 1.9512832164764404 0.19416569353031607 1.8759093284606934 24.59916045611385 54.29293954388615 19.880828181873486 40.040321818126515 30.430377405015573 88.46017259498443 UP 0.75 0.25 0.0 GO:0006835 8 dicarboxylic acid transport 18 18 2 2 2 2 2 2 94 16 2435 0.97193 0.14569 0.14569 11.11 117267;503568 slc26a2;slc13a4 SLC26A2_33072;SLC13A4_9836 60.18445 60.18445 54.7452 7.692261119137861 57.61982953367875 6.783533360458549 40.5197 40.5197 38.3503 3.067994902212159 39.49682227979274 2.7055563307770147 115.54065 115.54065 95.3373 28.571851575370424 106.01471813471503 25.19650663566071 0.0 54.7452 0.5 60.18445 54.7452;65.6237 38.3503;42.6891 95.3373;135.744 0 2 0 2 117267;503568 SLC26A2_33072;SLC13A4_9836 60.18445 60.18445 7.692261119137861 40.5197 40.5197 3.067994902212159 115.54065 115.54065 28.571851575370424 54.7452;65.6237 38.3503;42.6891 95.3373;135.744 0 Exp 2,1(0.5);Linear,1(0.5) 1.5294441179733647 3.0589083433151245 1.5239086151123047 1.5349997282028198 0.00784260127721014 1.5294541716575623 49.52352 70.84538 36.267675999999994 44.771724000000006 75.942084 155.139216 DOWN 0.0 1.0 0.0 GO:0046165 5 alcohol biosynthetic process 38 41 5 4 3 5 2 2 94 39 2412 0.8007 0.46207 0.66641 4.88 25315;25427 ephx1;cyp51 EPHX1_8567;CYP51_8429 54.58279999999999 54.58279999999999 34.0134 29.08952444987716 44.1738959646539 25.090035198977116 37.12795 37.12795 26.1579 15.51399348991097 31.576684639175262 13.380990239605381 109.87355 109.87355 48.3681 86.98184154986028 78.74943715758468 75.02279626187092 34.0134;75.1522 26.1579;48.098 48.3681;171.379 1 1 1 25315 EPHX1_8567 34.0134 34.0134 26.1579 26.1579 48.3681 48.3681 34.0134 26.1579 48.3681 1 25427 CYP51_8429 75.1522 75.1522 48.098 48.098 171.379 171.379 75.1522 48.098 171.379 0 Linear,2(1) 1.8076555345026355 3.633850932121277 1.633623480796814 2.000227451324463 0.2592281535700138 1.8169254660606384 14.266776 94.89882399999999 15.626652000000004 58.62924799999999 -10.677131999999986 230.42423199999996 CONFLICT 0.5 0.5 0.0 GO:0048513 4 animal organ development 418 452 20 20 13 19 13 13 83 439 2012 0.16807 0.89491 0.3399 2.88 360243;78968;24950;25664;54133;24614;291234;25315;50549;24303;114494;25612;25649 top2a;srebf1;srd5a1;pparg;pdlim1;orm1;mki67;ephx1;cyp4a1;cyp2d3;ccna2;asns;apoa2 TOP2A_10059;SREBF1_32750;SRD5A1_32503;PPARG_32510;PDLIM1_9452;ORM1_9400;MKI67_9232;EPHX1_8567;CYP4A1_33111;CYP2D3_8420;CCNA2_8221;ASNS_8091;APOA2_33095 25664(0.0441) 37.02286769230769 34.0134 3.54778 19.155197393812013 38.066910054098024 20.610512737543274 25.821864615384616 23.1774 1.51564 13.15141095235071 26.718074138973627 14.487420144204117 68.65655000000001 48.3681 8.55785 56.42039688168336 69.5814915415904 54.46240387980999 54.9577;41.2009;29.2087;60.1903;67.1147;24.2519;49.7822;34.0134;23.208;12.8059;52.8265;28.1893;3.54778 18.8326;31.4864;22.9308;43.9036;47.2419;19.7133;35.6665;26.1579;18.863;8.8664;37.3288;23.1774;1.51564 218.525;60.0774;39.9852;101.057;123.914;31.358;82.1147;48.3681;29.9853;22.6004;90.0448;35.9474;8.55785 9 4 9 78968;25664;54133;24614;25315;50549;24303;25612;25649 SREBF1_32750;PPARG_32510;PDLIM1_9452;ORM1_9400;EPHX1_8567;CYP4A1_33111;CYP2D3_8420;ASNS_8091;APOA2_33095 32.72468666666666 28.1893 20.741007158238485 24.54728222222222 23.1774 14.892782629862854 51.31838333333334 35.9474 38.03361727715364 41.2009;60.1903;67.1147;24.2519;34.0134;23.208;12.8059;28.1893;3.54778 31.4864;43.9036;47.2419;19.7133;26.1579;18.863;8.8664;23.1774;1.51564 60.0774;101.057;123.914;31.358;48.3681;29.9853;22.6004;35.9474;8.55785 4 360243;24950;291234;114494 TOP2A_10059;SRD5A1_32503;MKI67_9232;CCNA2_8221 46.693775 51.30435 11.84861439251441 28.689675 29.298650000000002 9.194874236361246 107.66742500000001 86.07974999999999 77.10119796442312 54.9577;29.2087;49.7822;52.8265 18.8326;22.9308;35.6665;37.3288 218.525;39.9852;82.1147;90.0448 0 Exp 2,7(0.54);Hill,1(0.08);Linear,4(0.31);Poly 2,1(0.08) 2.0560825412325614 27.649633765220642 1.5239794254302979 3.5849626064300537 0.6277663256642825 1.9512832164764404 26.609983774288786 47.43575161032661 18.6726761841952 32.971053046574035 37.98607288305243 99.32702711694756 UP 0.6923076923076923 0.3076923076923077 0.0 GO:0051094 5 positive regulation of developmental process 376 396 14 13 11 14 10 10 86 386 2065 0.097772 0.94662 0.19533 2.53 29142;360268;25664;24484;24471;29455;58868;64515;25599;502970 vnn1;sult1e1;pparg;igfbp3;hspb1;gdf15;fzd1;cdc20;cd74;angptl3 VNN1_10157;SULT1E1_32446;PPARG_32510;IGFBP3_8881;HSPB1_8847;GDF15_33113;FZD1_8671;CDC20_8255;CD74_8252;ANGPTL3_8045 25664(0.0441) 53.39263 54.50945 20.7328 28.239924610422264 60.25932617814298 24.393845948285612 35.53089999999999 38.191900000000004 13.6792 15.439033142942904 40.32102745372635 13.323482007395844 120.28666000000001 96.3074 26.3528 122.21080781324083 125.11965993554593 107.57235630622469 20.7328;59.2729;60.1903;50.946;41.6322;21.3654;25.231;101.569;94.9138;58.0729 16.8296;45.3114;43.9036;36.3081;30.9494;17.8875;13.6792;51.5499;58.8146;40.0757 26.7838;91.5578;101.057;85.0816;63.3196;26.3528;131.659;453.17;118.773;105.112 8 2 8 29142;360268;25664;24471;29455;58868;25599;502970 VNN1_10157;SULT1E1_32446;PPARG_32510;HSPB1_8847;GDF15_33113;FZD1_8671;CD74_8252;ANGPTL3_8045 47.6764125 49.852549999999994 25.604381079441268 33.431374999999996 35.51255 16.269152479703955 83.076875 96.3074 40.16408278221262 20.7328;59.2729;60.1903;41.6322;21.3654;25.231;94.9138;58.0729 16.8296;45.3114;43.9036;30.9494;17.8875;13.6792;58.8146;40.0757 26.7838;91.5578;101.057;63.3196;26.3528;131.659;118.773;105.112 2 24484;64515 IGFBP3_8881;CDC20_8255 76.2575 76.2575 35.79586658400661 43.929 43.929 10.77758013748912 269.1258 269.1258 260.27780371610635 50.946;101.569 36.3081;51.5499 85.0816;453.17 0 Exp 2,4(0.4);Linear,4(0.4);Poly 2,2(0.2) 2.1345181427617983 23.915064573287964 1.5124053955078125 5.015069484710693 1.3484653166026777 1.6978691816329956 35.889343386806 70.895916613194 25.961688117904608 45.10011188209538 44.53961655372723 196.03370344627277 UP 0.8 0.2 0.0 GO:0062197 5 cellular response to chemical stress 112 118 5 5 3 5 3 3 93 115 2336 0.34059 0.83244 0.62442 2.54 25664;24471;114494 pparg;hspb1;ccna2 PPARG_32510;HSPB1_8847;CCNA2_8221 25664(0.0441) 51.54966666666667 52.8265 41.6322 9.344704191323176 52.73276259512518 9.900407045400566 37.39393333333333 37.3288 30.9494 6.477345611694165 38.39450681592589 6.943694200949152 84.80713333333334 90.0448 63.3196 19.406254243756905 86.73038093084814 20.24135032024604 60.1903;41.6322;52.8265 43.9036;30.9494;37.3288 101.057;63.3196;90.0448 2 1 2 25664;24471 PPARG_32510;HSPB1_8847 50.911249999999995 50.911249999999995 13.12255835593807 37.4265 37.4265 9.160002664846768 82.1883 82.1883 26.684371444349228 60.1903;41.6322 43.9036;30.9494 101.057;63.3196 1 114494 CCNA2_8221 52.8265 52.8265 37.3288 37.3288 90.0448 90.0448 52.8265 37.3288 90.0448 0 Exp 2,1(0.34);Linear,2(0.67) 1.8706031176232654 5.696425676345825 1.5239794254302979 2.3255980014801025 0.4033273988679277 1.8468482494354248 40.97513840516524 62.124194928168095 30.06412675754346 44.723739909123196 62.84688935460639 106.76737731206026 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0061668 8 mitochondrial ribosome assembly 2 2 1 1 1 1 1 1 95 1 2450 0.99859 0.073976 0.073976 50.0 362094 mrps2 MRPS2_9250 63.3158 63.3158 63.3158 63.3158 45.3429 45.3429 45.3429 45.3429 111.245 111.245 111.245 111.245 0.0 63.3158 0.0 63.3158 63.3158 45.3429 111.245 1 0 1 362094 MRPS2_9250 63.3158 63.3158 45.3429 45.3429 111.245 111.245 63.3158 45.3429 111.245 0 0 Exp 2,1(1) 1.5277283191680908 1.5277283191680908 1.5277283191680908 1.5277283191680908 0.0 1.5277283191680908 63.3158 63.3158 45.3429 45.3429 111.245 111.245 UP 1.0 0.0 0.0 GO:0010605 6 negative regulation of macromolecule metabolic process 531 562 22 21 17 22 16 16 80 546 1905 0.11804 0.92683 0.21146 2.85 78968;84386;299270;309607;24679;25664;24614;65035;259241;24484;24471;299626;58868;25427;25649;155423 srebf1;slpi;serpina6;rt1-ce5;prkar2b;pparg;orm1;nr1i3;nr1d2;igfbp3;hspb1;gadd45b;fzd1;cyp51;apoa2;anxa7 SREBF1_32750;SLPI_9890;SERPINA6_32325;RT1-CE5_32445;PRKAR2B_33052;PPARG_32510;ORM1_9400;NR1I3_32602;NR1D2_9358;IGFBP3_8881;HSPB1_8847;GADD45B_8679;FZD1_8671;CYP51_8429;APOA2_33095;ANXA7_8051 25664(0.0441) 52.894017500000004 53.15735 3.54778 27.589976472013028 48.739862899954744 24.137371980844723 32.655715 36.638000000000005 1.51564 14.827889556125875 31.07817346579457 13.49941607511165 94.083240625 91.02625 8.55785 44.1978135220406 84.77278082654574 39.18405983717383 41.2009;53.7429;68.3847;54.8206;108.746;60.1903;24.2519;22.095;99.0234;50.946;41.6322;52.5718;25.231;75.1522;3.54778;64.7676 31.4864;37.8192;36.9679;26.5902;59.3814;43.9036;19.7133;12.9529;42.5557;36.3081;30.9494;37.1918;13.6792;48.098;1.51564;43.3787 60.0774;92.543;89.5095;147.824;147.467;101.057;31.358;55.8619;102.838;85.0816;63.3196;89.36;131.659;171.379;8.55785;127.439 12 4 12 78968;299270;24679;25664;24614;65035;259241;24471;299626;58868;25649;155423 SREBF1_32750;SERPINA6_32325;PRKAR2B_33052;PPARG_32510;ORM1_9400;NR1I3_32602;NR1D2_9358;HSPB1_8847;GADD45B_8679;FZD1_8671;APOA2_33095;ANXA7_8051 50.970214999999996 47.102000000000004 31.43541149024848 31.139661666666665 34.22715 16.390566815996127 84.04202083333332 89.43475000000001 41.71949855054404 41.2009;68.3847;108.746;60.1903;24.2519;22.095;99.0234;41.6322;52.5718;25.231;3.54778;64.7676 31.4864;36.9679;59.3814;43.9036;19.7133;12.9529;42.5557;30.9494;37.1918;13.6792;1.51564;43.3787 60.0774;89.5095;147.467;101.057;31.358;55.8619;102.838;63.3196;89.36;131.659;8.55785;127.439 4 84386;309607;24484;25427 SLPI_9890;RT1-CE5_32445;IGFBP3_8881;CYP51_8429 58.665425 54.28175 11.111813591661509 37.203875 37.06365 8.803656328054855 124.20689999999999 120.18350000000001 42.09657980612366 53.7429;54.8206;50.946;75.1522 37.8192;26.5902;36.3081;48.098 92.543;147.824;85.0816;171.379 0 Exp 2,4(0.25);Hill,1(0.07);Linear,6(0.38);Poly 2,3(0.19);Power,2(0.13) 1.8503488081724677 30.448359608650208 1.5124053955078125 3.5849626064300537 0.5363582283674919 1.7321282625198364 39.37492902871361 66.4131059712864 25.390049117498332 39.92138088250169 72.42631199920012 115.74016925079988 UP 0.75 0.25 0.0 GO:0048285 6 organelle fission 20 20 3 3 2 3 2 2 94 18 2433 0.96285 0.17256 0.17256 10.0 360243;50681 top2a;acox1 TOP2A_10059;ACOX1_7973 39.37955 39.37955 23.8014 22.03083100668243 45.99137430598396 19.948059392798072 18.96595 18.96595 18.8326 0.1885853785426933 18.909352344231955 0.17075671501613035 124.93965 124.93965 31.3543 132.34967120943296 164.66002063541026 119.8374723632649 0.0 23.8014 1.0 54.9577 54.9577;23.8014 18.8326;19.0993 218.525;31.3543 1 1 1 50681 ACOX1_7973 23.8014 23.8014 19.0993 19.0993 31.3543 31.3543 23.8014 19.0993 31.3543 1 360243 TOP2A_10059 54.9577 54.9577 18.8326 18.8326 218.525 218.525 54.9577 18.8326 218.525 0 Exp 2,1(0.5);Linear,1(0.5) 1.6857336276338846 3.379489779472351 1.5733836889266968 1.8061060905456543 0.16455958831878403 1.6897448897361755 8.846376000000006 69.912724 18.704584 19.227316 -58.48763600000004 308.366936 CONFLICT 0.5 0.5 0.0 GO:0008202 5 steroid metabolic process 95 104 15 14 11 15 10 10 86 94 2357 0.99852 0.0049629 0.0049629 9.62 360268;64305;78968;24950;299270;25427;266682;25086;25649;502970 sult1e1;sult1b1;srebf1;srd5a1;serpina6;cyp51;cyp3a2;cyp2e1;apoa2;angptl3 SULT1E1_32446;SULT1B1_32942;SREBF1_32750;SRD5A1_32503;SERPINA6_32325;CYP51_8429;CYP3A2_32374;CYP2E1_8421;APOA2_33095;ANGPTL3_8045 38.144322 35.2048 3.54778 25.95998713334119 38.73396344917301 24.194719124882866 25.694349 27.2086 1.51564 17.265374687104206 26.157752289251352 16.39888756034841 64.758905 50.0313 8.55785 50.07821648136736 61.9559861900133 39.15925720171947 4.5 35.2048 59.2729;15.4629;41.2009;29.2087;68.3847;75.1522;23.2485;7.89174;3.54778;58.0729 45.3114;7.69418;31.4864;22.9308;36.9679;48.098;18.6955;4.16797;1.51564;40.0757 91.5578;35.0879;60.0774;39.9852;89.5095;171.379;30.5145;15.8079;8.55785;105.112 8 2 8 360268;64305;78968;299270;266682;25086;25649;502970 SULT1E1_32446;SULT1B1_32942;SREBF1_32750;SERPINA6_32325;CYP3A2_32374;CYP2E1_8421;APOA2_33095;ANGPTL3_8045 34.63529 32.2247 25.40346874082694 23.23933625 25.09095 17.423551326328344 54.52810624999999 47.58265 37.323900484909885 59.2729;15.4629;41.2009;68.3847;23.2485;7.89174;3.54778;58.0729 45.3114;7.69418;31.4864;36.9679;18.6955;4.16797;1.51564;40.0757 91.5578;35.0879;60.0774;89.5095;30.5145;15.8079;8.55785;105.112 2 24950;25427 SRD5A1_32503;CYP51_8429 52.18044999999999 52.18044999999999 32.48696040144416 35.5144 35.5144 17.795897783478058 105.68209999999999 105.68209999999999 92.909446985869 29.2087;75.1522 22.9308;48.098 39.9852;171.379 0 Exp 2,2(0.2);Exp 4,2(0.2);Hill,1(0.1);Linear,4(0.4);Poly 2,1(0.1) 1.9588726597327868 20.492579698562622 1.5310101509094238 3.7662253379821777 0.7306314952642917 1.7976728081703186 22.054155275475416 54.23448872452459 14.993158901176615 36.39553909882339 33.72010485293964 95.79770514706038 UP 0.8 0.2 0.0 GO:0032966 7 negative regulation of collagen biosynthetic process 9 9 2 2 2 2 2 2 94 7 2444 0.9963 0.042588 0.042588 22.22 25664;65210 pparg;cyp2j4 PPARG_32510;CYP2J4_32580 25664(0.0441) 38.2529 38.2529 16.3155 31.024168603203535 37.59818253083963 31.010348717664435 26.0707 26.0707 8.2378 25.219529036443163 25.538480541185827 25.20829485933785 68.9496 68.9496 36.8422 45.40672053253792 67.99136084361321 45.38649386060061 0.0 16.3155 0.0 16.3155 60.1903;16.3155 43.9036;8.2378 101.057;36.8422 2 0 2 25664;65210 PPARG_32510;CYP2J4_32580 38.2529 38.2529 31.024168603203535 26.0707 26.0707 25.219529036443163 68.9496 68.9496 45.40672053253792 60.1903;16.3155 43.9036;8.2378 101.057;36.8422 0 0 Exp 2,1(0.5);Exp 4,1(0.5) 1.7196651227095043 3.464457154273987 1.5239794254302979 1.940477728843689 0.29450877469630105 1.7322285771369934 -4.744403999999996 81.250204 -8.881784 61.023184 6.019096000000012 131.880104 UP 1.0 0.0 0.0 GO:0010629 7 negative regulation of gene expression 355 375 14 13 10 14 9 9 87 366 2085 0.081495 0.9578 0.14364 2.4 78968;309607;25664;24614;65035;259241;58868;25649;155423 srebf1;rt1-ce5;pparg;orm1;nr1i3;nr1d2;fzd1;apoa2;anxa7 SREBF1_32750;RT1-CE5_32445;PPARG_32510;ORM1_9400;NR1I3_32602;NR1D2_9358;FZD1_8671;APOA2_33095;ANXA7_8051 25664(0.0441) 43.90316444444444 41.2009 3.54778 28.94888483386499 40.16873494796802 25.55181188496456 26.197293333333334 26.5902 1.51564 15.361409931851956 25.324195118486873 14.658148165459941 85.18579444444443 101.057 8.55785 48.33700461061411 77.74114767134041 47.098870916870936 41.2009;54.8206;60.1903;24.2519;22.095;99.0234;25.231;3.54778;64.7676 31.4864;26.5902;43.9036;19.7133;12.9529;42.5557;13.6792;1.51564;43.3787 60.0774;147.824;101.057;31.358;55.8619;102.838;131.659;8.55785;127.439 8 1 8 78968;25664;24614;65035;259241;58868;25649;155423 SREBF1_32750;PPARG_32510;ORM1_9400;NR1I3_32602;NR1D2_9358;FZD1_8671;APOA2_33095;ANXA7_8051 42.538484999999994 33.21595 30.636612704401813 26.148180000000004 25.59985 16.421282567581095 77.35601874999999 80.5672 45.16278528546911 41.2009;60.1903;24.2519;22.095;99.0234;25.231;3.54778;64.7676 31.4864;43.9036;19.7133;12.9529;42.5557;13.6792;1.51564;43.3787 60.0774;101.057;31.358;55.8619;102.838;131.659;8.55785;127.439 1 309607 RT1-CE5_32445 54.8206 54.8206 26.5902 26.5902 147.824 147.824 54.8206 26.5902 147.824 0 Exp 2,4(0.45);Hill,1(0.12);Linear,1(0.12);Poly 2,2(0.23);Power,1(0.12) 1.969864653193854 18.473153352737427 1.5124053955078125 3.5849626064300537 0.6866386806186385 1.8475407361984253 24.98989301965266 62.81643586923623 16.16117217785672 36.23341448880994 53.60561809884324 116.76597079004564 UP 0.8888888888888888 0.1111111111111111 0.0 GO:0043066 8 negative regulation of apoptotic process 279 296 9 9 7 9 7 7 89 289 2162 0.11347 0.94259 0.25319 2.36 29142;63868;24471;25599;25612;50559;170465 vnn1;hspd1;hspb1;cd74;asns;acot1;acaa2 VNN1_10157;HSPD1_8849;HSPB1_8847;CD74_8252;ASNS_8091;ACOT1_7968;ACAA2_7955 46.68939999999999 34.4455 20.7328 28.439798763762973 56.969927440587135 30.094048966143575 32.115871428571424 26.6907 16.8296 14.39703994561781 37.30487807257689 15.257083329909634 60.79234285714286 48.4857 26.7838 35.31473767743702 74.1254575605778 36.190127236461095 20.7328;34.4455;41.6322;94.9138;28.1893;28.5134;78.3988 16.8296;26.6907;30.9494;58.8146;23.1774;24.741;43.6084 26.7838;48.4857;63.3196;118.773;35.9474;33.4642;98.7727 6 1 6 29142;63868;24471;25599;25612;50559 VNN1_10157;HSPD1_8849;HSPB1_8847;CD74_8252;ASNS_8091;ACOT1_7968 41.40449999999999 31.47945 27.12882550321706 30.20045 25.71585 14.761824458480726 54.46228333333334 42.21655 34.05835795574511 20.7328;34.4455;41.6322;94.9138;28.1893;28.5134 16.8296;26.6907;30.9494;58.8146;23.1774;24.741 26.7838;48.4857;63.3196;118.773;35.9474;33.4642 1 170465 ACAA2_7955 78.3988 78.3988 43.6084 43.6084 98.7727 98.7727 78.3988 43.6084 98.7727 0 Exp 2,3(0.43);Linear,2(0.29);Poly 2,2(0.29) 3.5204490364579777 65.64661300182343 1.6557694673538208 50.888092041015625 18.338117753121953 1.8468482494354248 25.62090223762109 67.7578977623789 21.45039498133252 42.78134787581034 34.63081907434814 86.95386663993757 UP 0.8571428571428571 0.14285714285714285 0.0 GO:0045834 6 positive regulation of lipid metabolic process 76 82 8 8 5 8 5 5 91 77 2374 0.91396 0.19439 0.23505 6.1 78968;25664;25599;25649;502970 srebf1;pparg;cd74;apoa2;angptl3 SREBF1_32750;PPARG_32510;CD74_8252;APOA2_33095;ANGPTL3_8045 25664(0.0441) 51.585136 58.0729 3.54778 33.19989827539355 54.132122128451 30.47972726977718 35.159188 40.0757 1.51564 21.246135190210943 37.061635045530295 19.18451399691048 78.71545 101.057 8.55785 44.916577579636424 83.23226718557522 41.11224505702493 3.5 77.55205 41.2009;60.1903;94.9138;3.54778;58.0729 31.4864;43.9036;58.8146;1.51564;40.0757 60.0774;101.057;118.773;8.55785;105.112 5 0 5 78968;25664;25599;25649;502970 SREBF1_32750;PPARG_32510;CD74_8252;APOA2_33095;ANGPTL3_8045 51.585136 58.0729 33.19989827539355 35.159188 40.0757 21.246135190210943 78.71545 101.057 44.916577579636424 41.2009;60.1903;94.9138;3.54778;58.0729 31.4864;43.9036;58.8146;1.51564;40.0757 60.0774;101.057;118.773;8.55785;105.112 0 0 Exp 2,2(0.4);Hill,1(0.2);Linear,1(0.2);Poly 2,1(0.2) 1.6657534618644256 8.358114123344421 1.5239794254302979 1.912555456161499 0.15889344888800985 1.6577342748641968 22.484142079175662 80.68612992082433 16.536129402570857 53.78224659742914 39.344333852393646 118.08656614760633 UP 1.0 0.0 0.0 GO:0034654 5 nucleobase-containing compound biosynthetic process 143 160 5 5 4 5 4 4 92 156 2295 0.26714 0.865 0.52007 2.5 78968;298490;313245;364975 srebf1;ppcs;polr1e;gcdh SREBF1_32750;PPCS_9540;POLR1E_9523;GCDH_8693 36.548525 28.551499999999997 15.1091 27.741866395561182 32.9797064011151 20.56919817035426 24.3596775 20.95455 7.94061 18.74581479340633 23.17114884040101 15.265106978713481 71.928075 45.6796 30.6311 64.01900415862855 56.94540091138155 42.67626367106302 41.2009;15.1091;73.982;15.9021 31.4864;7.94061;47.589;10.4227 60.0774;30.6311;165.722;31.2818 4 0 4 78968;298490;313245;364975 SREBF1_32750;PPCS_9540;POLR1E_9523;GCDH_8693 36.548525 28.551499999999997 27.741866395561182 24.3596775 20.95455 18.74581479340633 71.928075 45.6796 64.01900415862855 41.2009;15.1091;73.982;15.9021 31.4864;7.94061;47.589;10.4227 60.0774;30.6311;165.722;31.2818 0 0 Exp 2,1(0.25);Hill,1(0.25);Linear,1(0.25);Poly 2,1(0.25) 1.709563953951978 6.879365921020508 1.5184675455093384 1.912555456161499 0.21671689905404767 1.7241714596748352 9.361495932350039 63.73555406764996 5.98877900246179 42.7305759975382 9.189450924544033 134.666699075456 UP 1.0 0.0 0.0 GO:0042573 8 retinoic acid metabolic process 6 6 2 2 1 2 1 1 95 5 2446 0.9809 0.20606 0.20606 16.67 499353 cyp2c24 CYP2C24_32875 58.9435 58.9435 58.9435 58.94350000000001 48.1505 48.1505 48.1505 48.1505 80.4167 80.4167 80.4167 80.4167 0.0 58.9435 0.0 58.9435 58.9435 48.1505 80.4167 1 0 1 499353 CYP2C24_32875 58.9435 58.9435 48.1505 48.1505 80.4167 80.4167 58.9435 48.1505 80.4167 0 0 Exp 2,1(1) 2.6958487033843994 2.6958487033843994 2.6958487033843994 2.6958487033843994 0.0 2.6958487033843994 58.9435 58.9435 48.1505 48.1505 80.4167 80.4167 UP 1.0 0.0 0.0 GO:1901564 4 organonitrogen compound metabolic process 832 911 34 34 29 33 29 29 67 882 1569 0.14661 0.89862 0.27824 3.18 29142;365813;360268;64305;24950;293820;298490;25664;680308;362094;291234;315994;24484;364975;171142;114027;311849;297594;64515;114494;25612;25649;65155;24763;681337;314304;192272;50559;170465 vnn1;trim59;sult1e1;sult1b1;srd5a1;psat1;ppcs;pparg;mthfd2;mrps2;mki67;mapkapk3;igfbp3;gcdh;ehhadh;dao;crat;cdca3;cdc20;ccna2;asns;apoa2;alas1;acsm3;acot4;acot3;acot2;acot1;acaa2 VNN1_10157;TRIM59_10085;SULT1E1_32446;SULT1B1_32942;SRD5A1_32503;PSAT1_9583;PPCS_9540;PPARG_32510;MTHFD2_9261;MRPS2_9250;MKI67_9232;MAPKAPK3_9194;IGFBP3_8881;GCDH_8693;EHHADH_8534;DAO_8437;CRAT_8375;CDCA3_8260;CDC20_8255;CCNA2_8221;ASNS_8091;APOA2_33095;ALAS1_8018;ACSM3_7976;ACOT4_7971;ACOT3_7970;ACOT2_7969;ACOT1_7968;ACAA2_7955 25664(0.0441) 38.703696206896545 29.2087 3.54778 27.230284962628392 42.47655600905174 29.0788731737756 25.91963103448276 23.1774 1.51564 16.92888632498444 27.87056683518006 18.083116261511694 82.89908448275864 39.9852 8.55785 106.08964266532463 94.23840668912115 113.7564704013677 20.7328;56.1278;59.2729;15.4629;29.2087;26.3316;15.1091;60.1903;57.4184;63.3158;49.7822;104.193;50.946;15.9021;7.29984;6.1336;8.98517;46.7245;101.569;52.8265;28.1893;3.54778;27.1843;52.2057;12.3157;30.8838;13.6362;28.5134;78.3988 16.8296;33.6269;45.3114;7.69418;22.9308;20.9188;7.94061;43.9036;46.387;45.3429;35.6665;59.1667;36.3081;10.4227;5.26587;2.43617;1.97988;21.1123;51.5499;37.3288;23.1774;1.51564;21.5215;42.2655;6.70485;24.6874;11.3249;24.741;43.6084 26.7838;121.883;91.5578;35.0879;39.9852;35.2954;30.6311;101.057;79.7903;111.245;82.1147;434.985;85.0816;31.2818;11.8779;16.2027;31.3726;127.486;453.17;90.0448;35.9474;8.55785;36.6615;71.1126;24.3993;41.2585;16.9658;33.4642;98.7727 20 9 20 29142;360268;64305;293820;298490;25664;680308;362094;364975;171142;114027;311849;25612;25649;65155;24763;681337;314304;192272;50559 VNN1_10157;SULT1E1_32446;SULT1B1_32942;PSAT1_9583;PPCS_9540;PPARG_32510;MTHFD2_9261;MRPS2_9250;GCDH_8693;EHHADH_8534;DAO_8437;CRAT_8375;ASNS_8091;APOA2_33095;ALAS1_8018;ACSM3_7976;ACOT4_7971;ACOT3_7970;ACOT2_7969;ACOT1_7968 27.631534499999997 23.532200000000003 19.95135579943734 20.518545 18.874200000000002 16.126636235264378 43.5275225 34.27605 30.27518654164997 20.7328;59.2729;15.4629;26.3316;15.1091;60.1903;57.4184;63.3158;15.9021;7.29984;6.1336;8.98517;28.1893;3.54778;27.1843;52.2057;12.3157;30.8838;13.6362;28.5134 16.8296;45.3114;7.69418;20.9188;7.94061;43.9036;46.387;45.3429;10.4227;5.26587;2.43617;1.97988;23.1774;1.51564;21.5215;42.2655;6.70485;24.6874;11.3249;24.741 26.7838;91.5578;35.0879;35.2954;30.6311;101.057;79.7903;111.245;31.2818;11.8779;16.2027;31.3726;35.9474;8.55785;36.6615;71.1126;24.3993;41.2585;16.9658;33.4642 9 365813;24950;291234;315994;24484;297594;64515;114494;170465 TRIM59_10085;SRD5A1_32503;MKI67_9232;MAPKAPK3_9194;IGFBP3_8881;CDCA3_8260;CDC20_8255;CCNA2_8221;ACAA2_7955 63.30850000000001 52.8265 25.7346501459122 37.92204444444444 36.3081 12.263695898271378 170.39144444444446 98.7727 157.25321024435488 56.1278;29.2087;49.7822;104.193;50.946;46.7245;101.569;52.8265;78.3988 33.6269;22.9308;35.6665;59.1667;36.3081;21.1123;51.5499;37.3288;43.6084 121.883;39.9852;82.1147;434.985;85.0816;127.486;453.17;90.0448;98.7727 0 Exp 2,11(0.38);Exp 4,1(0.04);Hill,6(0.21);Linear,9(0.32);Poly 2,2(0.07) 2.3877749883646633 114.52462077140808 1.5163835287094116 50.888092041015625 9.069193226837102 1.9512832164764404 28.792883736302727 48.61450867749038 19.758145103168204 32.081116965797314 44.286394421991325 121.51177454352592 UP 0.6896551724137931 0.3103448275862069 0.0 GO:0065003 6 protein-containing complex assembly 203 233 9 9 5 9 5 5 91 228 2223 0.11308 0.94875 0.20743 2.15 313245;316273;102551184;25599;25649 polr1e;mcm3;loc102551184;cd74;apoa2 POLR1E_9523;MCM3_9207;HIST1H4A_32934;CD74_8252;APOA2_33095 56.955676 58.3303 3.54778 33.888483562353166 56.4526426188696 37.03957064003891 36.277008 40.2068 1.51564 21.614859234154636 35.07523175538277 23.33927154297088 102.14157 111.753 8.55785 57.40973047380123 93.72351052444678 53.295041790153206 73.982;54.0045;58.3303;94.9138;3.54778 47.589;33.259;40.2068;58.8146;1.51564 165.722;111.753;105.902;118.773;8.55785 3 2 3 313245;25599;25649 POLR1E_9523;CD74_8252;APOA2_33095 57.48119333333333 73.982 47.86590506976896 35.97308 47.589 30.364286626812092 97.68428333333334 118.773 80.67647110087817 73.982;94.9138;3.54778 47.589;58.8146;1.51564 165.722;118.773;8.55785 2 316273;102551184 MCM3_9207;HIST1H4A_32934 56.1674 56.1674 3.058802514056686 36.7329 36.7329 4.912836494327889 108.8275 108.8275 4.137281776722447 54.0045;58.3303 33.259;40.2068 111.753;105.902 0 Exp 2,1(0.2);Hill,1(0.2);Linear,2(0.4);Poly 2,1(0.2) 1.6418184711561623 8.21628749370575 1.5184675455093384 1.7262524366378784 0.07590770512670454 1.6577342748641968 27.251110463276092 86.6602415367239 17.330748527909744 55.22326747209024 51.81972251553059 152.4634174844694 UP 0.6 0.4 0.0 GO:0031103 7 axon regeneration 17 18 2 2 1 2 1 1 95 17 2434 0.85431 0.50039 0.50039 5.56 338475 nrep NREP_9364 69.4104 69.4104 69.4104 69.4104 43.1468 43.1468 43.1468 43.1468 157.944 157.944 157.944 157.944 0.0 69.4104 69.4104 43.1468 157.944 0 1 0 1 338475 NREP_9364 69.4104 69.4104 43.1468 43.1468 157.944 157.944 69.4104 43.1468 157.944 0 Exp 2,1(1) 2.2143635749816895 2.2143635749816895 2.2143635749816895 2.2143635749816895 0.0 2.2143635749816895 69.4104 69.4104 43.1468 43.1468 157.944 157.944 DOWN 0.0 1.0 0.0 GO:1901570 5 fatty acid derivative biosynthetic process 18 23 4 4 4 4 4 4 92 19 2432 0.99866 0.0096719 0.0096719 17.39 364975;50549;29277;25599 gcdh;cyp4a1;cyp2c11;cd74 GCDH_8693;CYP4A1_33111;CYP2C11_32593;CD74_8252 47.112475 38.817 15.9021 35.98131808011623 61.258102920545284 32.951582430424715 33.013025 31.4074 10.4227 22.330278861428628 42.77449270304848 19.370307373848522 63.73155 53.08395 29.9853 42.212876660761545 81.36620492786871 37.31633267397182 0.5 19.55505 1.5 38.817 15.9021;23.208;54.426;94.9138 10.4227;18.863;43.9518;58.8146 31.2818;29.9853;74.8861;118.773 4 0 4 364975;50549;29277;25599 GCDH_8693;CYP4A1_33111;CYP2C11_32593;CD74_8252 47.112475 38.817 35.98131808011623 33.013025 31.4074 22.330278861428628 63.73155 53.08395 42.212876660761545 15.9021;23.208;54.426;94.9138 10.4227;18.863;43.9518;58.8146 31.2818;29.9853;74.8861;118.773 0 0 Exp 2,2(0.5);Poly 2,2(0.5) 1.9810616823750238 8.188245058059692 1.5464483499526978 2.9415390491485596 0.6330613173721256 1.8501288294792175 11.85078328148608 82.37416671851392 11.129351715799935 54.89669828420006 22.36293087245369 105.10016912754631 UP 1.0 0.0 0.0 GO:0018960 5 4-nitrophenol metabolic process 1 1 1 1 1 1 1 1 95 0 2451 1.0 0.037691 0.037691 100.0 25086 cyp2e1 CYP2E1_8421 7.89174 7.89174 7.89174 7.89174 4.16797 4.16797 4.16797 4.16797 15.8079 15.8079 15.8079 15.8079 0.0 7.89174 0.0 7.89174 7.89174 4.16797 15.8079 1 0 1 25086 CYP2E1_8421 7.89174 7.89174 4.16797 4.16797 15.8079 15.8079 7.89174 4.16797 15.8079 0 0 Exp 4,1(1) 1.5310101509094238 1.5310101509094238 1.5310101509094238 1.5310101509094238 0.0 1.5310101509094238 7.89174 7.89174 4.16797 4.16797 15.8079 15.8079 UP 1.0 0.0 0.0 GO:0052548 7 regulation of endopeptidase activity 137 148 5 5 4 5 4 4 92 144 2307 0.33365 0.8207 0.65636 2.7 84386;299270;25664;63868 slpi;serpina6;pparg;hspd1 SLPI_9890;SERPINA6_32325;PPARG_32510;HSPD1_8849 25664(0.0441) 54.19085 56.9666 34.4455 14.463036610039168 56.25941697995572 13.092827440076253 36.345349999999996 37.393550000000005 26.6907 7.139075850790051 37.29411663705227 6.426318284630981 82.89880000000001 91.02625 48.4857 23.457007673472184 86.415971794632 20.544979338780628 53.7429;68.3847;60.1903;34.4455 37.8192;36.9679;43.9036;26.6907 92.543;89.5095;101.057;48.4857 3 1 3 299270;25664;63868 SERPINA6_32325;PPARG_32510;HSPD1_8849 54.34016666666667 60.1903 17.7097535040252 35.85406666666666 36.9679 8.660337760349384 79.68406666666668 89.5095 27.628603856571026 68.3847;60.1903;34.4455 36.9679;43.9036;26.6907 89.5095;101.057;48.4857 1 84386 SLPI_9890 53.7429 53.7429 37.8192 37.8192 92.543 92.543 53.7429 37.8192 92.543 0 Exp 2,2(0.5);Linear,1(0.25);Poly 2,1(0.25) 1.6861935075723407 6.7628772258758545 1.5239794254302979 1.8690931797027588 0.14304375385755963 1.684902310371399 40.01707412216162 68.36462587783838 29.349055666225773 43.34164433377422 59.91093247999724 105.88666752000275 UP 0.75 0.25 0.0 GO:0017001 5 antibiotic catabolic process 20 22 3 3 3 3 3 3 93 19 2432 0.99178 0.047547 0.047547 13.64 286954;360268;64305 ugt2b1;sult1e1;sult1b1 UGT2B10_33303,UGT2B1_33224;SULT1E1_32446;SULT1B1_32942 29.093316666666666 15.4629 12.54415 26.176997784712313 31.44950632629945 26.719399986261177 20.117941666666667 7.69418 7.348245 21.8188605305389 21.914357047447243 22.44023451596524 50.71385 35.0879 25.495849999999997 35.69556057134416 54.36275185635776 35.95099384645606 0.5 14.003525 1.5 37.3679 12.54415;59.2729;15.4629 7.348245;45.3114;7.69418 25.495849999999997;91.5578;35.0879 4 0 3 286954;360268;64305 UGT2B10_33303,UGT2B1_33224;SULT1E1_32446;SULT1B1_32942 29.093316666666666 15.4629 26.176997784712313 20.117941666666667 7.69418 21.8188605305389 50.71385 35.0879 35.69556057134416 12.54415;59.2729;15.4629 7.348245;45.3114;7.69418 25.495849999999997;91.5578;35.0879 0 0 Exp 2,1(0.25);Exp 4,2(0.5);Poly 2,1(0.25) 1.916585189373507 7.9300618171691895 1.619360327720642 2.9455835819244385 0.6438940323358717 1.6825589537620544 -0.528744899789924 58.715378233123246 -4.572423334739703 44.80830666807304 10.320520650709312 91.10717934929067 UP 1.0 0.0 0.0 GO:0006464 6 cellular protein modification process 420 450 11 11 8 10 8 8 88 442 2009 0.0067952 0.99743 0.013379 1.78 365813;315994;24484;171142;297594;64515;114494;25649 trim59;mapkapk3;igfbp3;ehhadh;cdca3;cdc20;ccna2;apoa2 TRIM59_10085;MAPKAPK3_9194;IGFBP3_8881;EHHADH_8534;CDCA3_8260;CDC20_8255;CCNA2_8221;APOA2_33095 52.9043025 51.886250000000004 3.54778 36.96917342134419 56.467743118717216 38.12614614037108 30.73427625 34.9675 1.51564 20.42255856164238 32.732360473446775 21.028125419122137 166.63576875 105.9639 8.55785 176.9199074502377 184.0294095093905 184.34591852916677 56.1278;104.193;50.946;7.29984;46.7245;101.569;52.8265;3.54778 33.6269;59.1667;36.3081;5.26587;21.1123;51.5499;37.3288;1.51564 121.883;434.985;85.0816;11.8779;127.486;453.17;90.0448;8.55785 2 6 2 171142;25649 EHHADH_8534;APOA2_33095 5.42381 5.42381 2.6531070694187977 3.390755 3.390755 2.6518130640092252 10.217875 10.217875 2.3476298688784083 7.29984;3.54778 5.26587;1.51564 11.8779;8.55785 6 365813;315994;24484;297594;64515;114494 TRIM59_10085;MAPKAPK3_9194;IGFBP3_8881;CDCA3_8260;CDC20_8255;CCNA2_8221 68.73113333333333 54.47715 26.63934580890954 39.84878333333334 36.81845 13.555459637860546 218.77506666666667 124.6845 175.4165960823396 56.1278;104.193;50.946;46.7245;101.569;52.8265 33.6269;59.1667;36.3081;21.1123;51.5499;37.3288 121.883;434.985;85.0816;127.486;453.17;90.0448 0 Exp 2,3(0.38);Hill,2(0.25);Linear,3(0.38) 1.968132175851327 16.61849617958069 1.5163835287094116 3.9502921104431152 0.8259309866110673 1.7321282625198364 27.28597234332793 78.52263265667207 16.582165194845622 44.88638730515438 44.03652779073974 289.2350097092603 DOWN 0.25 0.75 0.0 GO:0050821 5 protein stabilization 40 48 3 3 2 3 2 2 94 46 2405 0.72979 0.54672 0.70212 4.17 63868;25649 hspd1;apoa2 HSPD1_8849;APOA2_33095 18.996640000000003 18.996640000000003 3.54778 21.847987335203218 18.282831287128715 21.824653601880105 14.10317 14.10317 1.51564 17.80145564277821 13.52156795379538 17.78244362064734 28.521775 28.521775 8.55785 28.233253493199296 27.599349422442245 28.203100271406065 34.4455;3.54778 26.6907;1.51564 48.4857;8.55785 2 0 2 63868;25649 HSPD1_8849;APOA2_33095 18.996640000000003 18.996640000000003 21.847987335203218 14.10317 14.10317 17.80145564277821 28.521775 28.521775 28.233253493199296 34.4455;3.54778 26.6907;1.51564 48.4857;8.55785 0 0 Exp 2,1(0.5);Hill,1(0.5) 1.6906436873363162 3.382021903991699 1.6557694673538208 1.7262524366378784 0.04983898553892028 1.6910109519958496 -11.283125599999998 49.2764056 -10.568388799999996 38.7747288 -10.607517999999995 67.651068 UP 1.0 0.0 0.0 GO:0009893 5 positive regulation of metabolic process 777 837 36 35 26 35 25 25 71 812 1639 0.08843 0.94308 0.18334 2.99 360243;78968;309607;25664;54133;24614;65035;259241;24484;63868;24471;29455;299626;58868;65030;117543;65210;25413;306575;64515;25599;114494;25649;502970;81633 top2a;srebf1;rt1-ce5;pparg;pdlim1;orm1;nr1i3;nr1d2;igfbp3;hspd1;hspb1;gdf15;gadd45b;fzd1;ephx2;decr1;cyp2j4;cpt2;ckap2;cdc20;cd74;ccna2;apoa2;angptl3;acta2 TOP2A_10059;SREBF1_32750;RT1-CE5_32445;PPARG_32510;PDLIM1_9452;ORM1_9400;NR1I3_32602;NR1D2_9358;IGFBP3_8881;HSPD1_8849;HSPB1_8847;GDF15_33113;GADD45B_8679;FZD1_8671;EPHX2_33282;DECR1_8458;CYP2J4_32580;CPT2_8374;CKAP2_8324;CDC20_8255;CD74_8252;CCNA2_8221;APOA2_33095;ANGPTL3_8045;ACTA2_33040 25664(0.0441) 47.6375852 50.946 3.54778 28.06890531353856 47.32480068742714 27.09032998450431 30.475152400000002 30.9494 1.51564 17.263498036128446 30.91640502180915 17.326372525349264 96.58699 89.36 8.55785 88.79326734959743 93.0236757921487 80.48269288873 54.9577;41.2009;54.8206;60.1903;67.1147;24.2519;22.095;99.0234;50.946;34.4455;41.6322;21.3654;52.5718;25.231;6.44145;21.6199;16.3155;31.2175;64.2131;101.569;94.9138;52.8265;3.54778;58.0729;90.3558 18.8326;31.4864;26.5902;43.9036;47.2419;19.7133;12.9529;42.5557;36.3081;26.6907;30.9494;17.8875;37.1918;13.6792;2.66377;17.4928;8.2378;24.8356;43.1133;51.5499;58.8146;37.3288;1.51564;40.0757;70.2676 218.525;60.0774;147.824;101.057;123.914;31.358;55.8619;102.838;85.0816;48.4857;63.3196;26.3528;89.36;131.659;17.3473;28.0829;36.8422;42.0237;125.437;453.17;118.773;90.0448;8.55785;105.112;103.57 18 7 18 78968;25664;54133;24614;65035;259241;63868;24471;29455;299626;58868;65030;117543;65210;25413;25599;25649;502970 SREBF1_32750;PPARG_32510;PDLIM1_9452;ORM1_9400;NR1I3_32602;NR1D2_9358;HSPD1_8849;HSPB1_8847;GDF15_33113;GADD45B_8679;FZD1_8671;EPHX2_33282;DECR1_8458;CYP2J4_32580;CPT2_8374;CD74_8252;APOA2_33095;ANGPTL3_8045 40.069496111111114 32.831500000000005 27.3608929713997 26.549350555555552 25.76315 16.190632536094842 66.16790833333334 57.96965 39.752382138729764 41.2009;60.1903;67.1147;24.2519;22.095;99.0234;34.4455;41.6322;21.3654;52.5718;25.231;6.44145;21.6199;16.3155;31.2175;94.9138;3.54778;58.0729 31.4864;43.9036;47.2419;19.7133;12.9529;42.5557;26.6907;30.9494;17.8875;37.1918;13.6792;2.66377;17.4928;8.2378;24.8356;58.8146;1.51564;40.0757 60.0774;101.057;123.914;31.358;55.8619;102.838;48.4857;63.3196;26.3528;89.36;131.659;17.3473;28.0829;36.8422;42.0237;118.773;8.55785;105.112 7 360243;309607;24484;306575;64515;114494;81633 TOP2A_10059;RT1-CE5_32445;IGFBP3_8881;CKAP2_8324;CDC20_8255;CCNA2_8221;ACTA2_33040 67.09838571428571 54.9577 20.41315752118623 40.57007142857143 37.3288 16.860172797030124 174.80748571428572 125.437 130.9406294237638 54.9577;54.8206;50.946;64.2131;101.569;52.8265;90.3558 18.8326;26.5902;36.3081;43.1133;51.5499;37.3288;70.2676 218.525;147.824;85.0816;125.437;453.17;90.0448;103.57 0 Exp 2,10(0.4);Exp 4,2(0.08);Hill,1(0.04);Linear,7(0.28);Poly 2,4(0.16);Power,1(0.04) 1.964473260256259 51.495397210121155 1.5124053955078125 5.015069484710693 0.7797614092824332 1.8468482494354248 36.6345743170929 58.64059608290712 23.707861169837642 37.24244363016235 61.780029198957806 131.3939508010422 UP 0.72 0.28 0.0 GO:0009894 5 regulation of catabolic process 212 227 10 9 7 10 6 6 90 221 2230 0.23269 0.87139 0.46438 2.64 78968;24484;25427;64515;25649;502970 srebf1;igfbp3;cyp51;cdc20;apoa2;angptl3 SREBF1_32750;IGFBP3_8881;CYP51_8429;CDC20_8255;APOA2_33095;ANGPTL3_8045 55.08146333333334 54.50945 3.54778 32.97989339685721 50.67544166776933 30.738652879236977 34.83895666666667 38.191900000000004 1.51564 17.923854440093702 33.00840634910133 16.89402754248176 147.22964166666668 95.0968 8.55785 159.1504622796755 126.02421593202118 148.67698775064315 41.2009;50.946;75.1522;101.569;3.54778;58.0729 31.4864;36.3081;48.098;51.5499;1.51564;40.0757 60.0774;85.0816;171.379;453.17;8.55785;105.112 3 3 3 78968;25649;502970 SREBF1_32750;APOA2_33095;ANGPTL3_8045 34.27386 41.2009 27.914782645129083 24.359246666666667 31.4864 20.243932245947995 57.91575 60.0774 48.31335755872799 41.2009;3.54778;58.0729 31.4864;1.51564;40.0757 60.0774;8.55785;105.112 3 24484;25427;64515 IGFBP3_8881;CYP51_8429;CDC20_8255 75.88906666666666 75.1522 25.31954307670924 45.31866666666667 48.098 7.991973294708442 236.54353333333333 171.379 192.50215546079832 50.946;75.1522;101.569 36.3081;48.098;51.5499 85.0816;171.379;453.17 0 Exp 2,2(0.34);Hill,1(0.17);Linear,3(0.5) 1.6744717349271023 10.077369809150696 1.5293418169021606 1.912555456161499 0.1447157258081853 1.6799379587173462 28.692052539396407 81.47087412727024 20.496886116631572 49.181027216701764 19.882749528333008 274.5765338050003 CONFLICT 0.5 0.5 0.0 GO:0031667 5 response to nutrient levels 239 256 14 14 11 14 11 11 85 245 2206 0.7472 0.36949 0.60401 4.3 78968;24950;25664;24614;24484;63868;58868;25612;65155;192272;114628 srebf1;srd5a1;pparg;orm1;igfbp3;hspd1;fzd1;asns;alas1;acot2;abcg5 SREBF1_32750;SRD5A1_32503;PPARG_32510;ORM1_9400;IGFBP3_8881;HSPD1_8849;FZD1_8671;ASNS_8091;ALAS1_8018;ACOT2_7969;ABCG5_7947 25664(0.0441) 33.417818181818184 29.2087 13.6362 13.084304766078947 34.42845319117385 14.154913632746265 24.995063636363636 23.1774 11.3249 9.453024432452585 25.764902617296396 10.141603680040827 57.973772727272724 48.4857 16.9658 34.38726656967926 57.90240076813571 33.380442576649315 41.2009;29.2087;60.1903;24.2519;50.946;34.4455;25.231;28.1893;27.1843;13.6362;33.1119 31.4864;22.9308;43.9036;19.7133;36.3081;26.6907;13.6792;23.1774;21.5215;11.3249;24.2098 60.0774;39.9852;101.057;31.358;85.0816;48.4857;131.659;35.9474;36.6615;16.9658;50.4329 8 3 8 78968;25664;24614;63868;58868;25612;65155;192272 SREBF1_32750;PPARG_32510;ORM1_9400;HSPD1_8849;FZD1_8671;ASNS_8091;ALAS1_8018;ACOT2_7969 31.791175000000003 27.686799999999998 13.968204446093173 23.937125 22.349449999999997 10.363260799815848 57.776475000000005 42.5736 39.113829853198965 41.2009;60.1903;24.2519;34.4455;25.231;28.1893;27.1843;13.6362 31.4864;43.9036;19.7133;26.6907;13.6792;23.1774;21.5215;11.3249 60.0774;101.057;31.358;48.4857;131.659;35.9474;36.6615;16.9658 3 24950;24484;114628 SRD5A1_32503;IGFBP3_8881;ABCG5_7947 37.75553333333333 33.1119 11.588789873120197 27.816233333333333 24.2098 7.381924536550994 58.4999 50.4329 23.605691898141856 29.2087;50.946;33.1119 22.9308;36.3081;24.2098 39.9852;85.0816;50.4329 0 Exp 2,6(0.55);Linear,4(0.37);Poly 2,1(0.1) 2.2062658683020904 25.984885454177856 1.5124053955078125 4.473705768585205 0.9873273245550751 1.912555456161499 25.685488188962196 41.15014817467416 19.408683186731388 30.58144408599589 37.65219680690788 78.29534864763755 UP 0.7272727272727273 0.2727272727272727 0.0 GO:0072330 7 monocarboxylic acid biosynthetic process 51 55 5 5 3 5 3 3 93 52 2399 0.84908 0.34353 0.46162 5.45 25599;25612;24763 cd74;asns;acsm3 CD74_8252;ASNS_8091;ACSM3_7976 58.43626666666666 52.2057 28.1893 33.795779260187714 72.90332698291057 35.38875174243766 41.41916666666667 42.2655 23.1774 17.833668047918035 47.970086880220705 18.28497443180804 75.27766666666666 71.1126 35.9474 41.56959031664052 92.23032408613687 43.301194780032795 1.5 73.55975 94.9138;28.1893;52.2057 58.8146;23.1774;42.2655 118.773;35.9474;71.1126 3 0 3 25599;25612;24763 CD74_8252;ASNS_8091;ACSM3_7976 58.43626666666666 52.2057 33.795779260187714 41.41916666666667 42.2655 17.833668047918035 75.27766666666666 71.1126 41.56959031664052 94.9138;28.1893;52.2057 58.8146;23.1774;42.2655 118.773;35.9474;71.1126 0 0 Exp 2,2(0.67);Poly 2,1(0.34) 2.418376914328891 7.5351420640945435 1.6577342748641968 3.2609751224517822 0.8067340329168607 2.6164326667785645 20.192742250115288 96.67979108321805 21.238471492382985 61.59986184095034 28.23724691421353 122.3180864191198 UP 1.0 0.0 0.0 GO:0002792 7 negative regulation of peptide secretion 35 37 6 6 5 6 5 5 91 32 2419 0.99779 0.011468 0.011468 13.51 78968;25664;25427;25599;25649 srebf1;pparg;cyp51;cd74;apoa2 SREBF1_32750;PPARG_32510;CYP51_8429;CD74_8252;APOA2_33095 25664(0.0441) 55.000996 60.1903 3.54778 34.87086143239195 54.017969378994344 34.37416425995921 36.763648 43.9036 1.51564 21.999786069130753 36.719498803810446 21.52920090956026 91.96885 101.057 8.55785 61.403355679412996 81.15465467110818 49.15708018507262 0.5 22.37434 2.5 67.67125 41.2009;60.1903;75.1522;94.9138;3.54778 31.4864;43.9036;48.098;58.8146;1.51564 60.0774;101.057;171.379;118.773;8.55785 4 1 4 78968;25664;25599;25649 SREBF1_32750;PPARG_32510;CD74_8252;APOA2_33095 49.963195 50.6956 38.106513571987925 33.93006 37.695 24.3267885897776 72.11631249999999 80.5672 48.9864724558113 41.2009;60.1903;94.9138;3.54778 31.4864;43.9036;58.8146;1.51564 60.0774;101.057;118.773;8.55785 1 25427 CYP51_8429 75.1522 75.1522 48.098 48.098 171.379 171.379 75.1522 48.098 171.379 0 Exp 2,2(0.4);Hill,1(0.2);Linear,1(0.2);Poly 2,1(0.2) 1.6860593807901179 8.454145073890686 1.5239794254302979 1.912555456161499 0.1437219137939522 1.6577342748641968 24.435338294052805 85.5666537059472 17.479985280716523 56.04731071928347 38.14643568046003 145.79126431953998 UP 0.8 0.2 0.0 GO:0005996 4 monosaccharide metabolic process 56 69 2 2 2 2 2 2 94 67 2384 0.51338 0.74285 1.0 2.9 286954;25685 ugt2b1;igfbp1 UGT2B10_33303,UGT2B1_33224;IGFBP1_32306 55.690625000000004 55.690625000000004 12.54415 61.018330113591695 31.745009197372188 50.75875862860647 32.338122500000004 32.338122500000004 7.348245 35.34102368254225 18.4691330734076 29.398813232852586 191.452425 191.452425 25.495849999999997 234.6980391299877 99.34913301913738 195.236105226562 12.54415;98.8371 7.348245;57.328 25.495849999999997;357.409 3 0 2 286954;25685 UGT2B10_33303,UGT2B1_33224;IGFBP1_32306 55.690625000000004 55.690625000000004 61.018330113591695 32.338122500000004 32.338122500000004 35.34102368254225 191.452425 191.452425 234.6980391299877 12.54415;98.8371 7.348245;57.328 25.495849999999997;357.409 0 0 Exp 4,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 1.7913034983741272 5.397053122520447 1.635288953781128 2.031935214996338 0.20717716300197167 1.729828953742981 -28.876465999999986 140.257716 -16.6420374 81.31828240000002 -133.82246199999994 516.7273119999999 UP 1.0 0.0 0.0 GO:0002682 4 regulation of immune system process 334 363 11 11 8 11 8 8 88 355 2096 0.054786 0.97401 0.10141 2.2 29142;309607;25664;24614;63868;102551184;25599;25649 vnn1;rt1-ce5;pparg;orm1;hspd1;loc102551184;cd74;apoa2 VNN1_10157;RT1-CE5_32445;PPARG_32510;ORM1_9400;HSPD1_8849;HIST1H4A_32934;CD74_8252;APOA2_33095 25664(0.0441) 43.9041225 44.63305 3.54778 28.87344506548819 46.85026136634831 30.978713139879986 29.283054999999997 26.64045 1.51564 17.8760436318131 30.952785292305 19.156692346875147 73.59266875 74.77135 8.55785 50.96842189823405 76.4337378816356 51.37476887476095 20.7328;54.8206;60.1903;24.2519;34.4455;58.3303;94.9138;3.54778 16.8296;26.5902;43.9036;19.7133;26.6907;40.2068;58.8146;1.51564 26.7838;147.824;101.057;31.358;48.4857;105.902;118.773;8.55785 6 2 6 29142;25664;24614;63868;25599;25649 VNN1_10157;PPARG_32510;ORM1_9400;HSPD1_8849;CD74_8252;APOA2_33095 39.68034666666667 29.3487 32.86762856561858 27.911240000000003 23.201999999999998 20.48901959706222 55.83589166666667 39.92185 44.1326591002221 20.7328;60.1903;24.2519;34.4455;94.9138;3.54778 16.8296;43.9036;19.7133;26.6907;58.8146;1.51564 26.7838;101.057;31.358;48.4857;118.773;8.55785 2 309607;102551184 RT1-CE5_32445;HIST1H4A_32934 56.575450000000004 56.575450000000004 2.48173266993033 33.3985 33.3985 9.628390196704753 126.863 126.863 29.643330480902545 54.8206;58.3303 26.5902;40.2068 147.824;105.902 0 Exp 2,4(0.5);Hill,1(0.13);Linear,2(0.25);Poly 2,1(0.13) 2.090585821966404 18.260160207748413 1.5239794254302979 4.608505725860596 1.1561650986755823 1.6919933557510376 23.895845874016523 63.91239912598348 16.89558876061519 41.67052123938481 38.27335433439415 108.91198316560585 UP 0.75 0.25 0.0 GO:0045597 6 positive regulation of cell differentiation 285 303 13 12 10 13 9 9 87 294 2157 0.27665 0.82517 0.52198 2.97 29142;360268;25664;24484;24471;29455;58868;64515;25599 vnn1;sult1e1;pparg;igfbp3;hspb1;gdf15;fzd1;cdc20;cd74 VNN1_10157;SULT1E1_32446;PPARG_32510;IGFBP3_8881;HSPB1_8847;GDF15_33113;FZD1_8671;CDC20_8255;CD74_8252 25664(0.0441) 52.8726 50.946 20.7328 29.902134685378236 60.69810857154433 26.87218336728478 35.02592222222221 36.3081 13.6792 16.287738752876194 40.370260932720164 14.689713851755478 121.97273333333334 91.5578 26.3528 129.5007133289234 129.13489219019064 118.14931048414255 20.7328;59.2729;60.1903;50.946;41.6322;21.3654;25.231;101.569;94.9138 16.8296;45.3114;43.9036;36.3081;30.9494;17.8875;13.6792;51.5499;58.8146 26.7838;91.5578;101.057;85.0816;63.3196;26.3528;131.659;453.17;118.773 7 2 7 29142;360268;25664;24471;29455;58868;25599 VNN1_10157;SULT1E1_32446;PPARG_32510;HSPB1_8847;GDF15_33113;FZD1_8671;CD74_8252 46.1912 41.6322 27.281136241305383 32.48218571428571 30.9494 17.331779481867848 79.929 91.5578 42.30280579205118 20.7328;59.2729;60.1903;41.6322;21.3654;25.231;94.9138 16.8296;45.3114;43.9036;30.9494;17.8875;13.6792;58.8146 26.7838;91.5578;101.057;63.3196;26.3528;131.659;118.773 2 24484;64515 IGFBP3_8881;CDC20_8255 76.2575 76.2575 35.79586658400661 43.929 43.929 10.77758013748912 269.1258 269.1258 260.27780371610635 50.946;101.569 36.3081;51.5499 85.0816;453.17 0 Exp 2,4(0.45);Linear,3(0.34);Poly 2,2(0.23) 2.213750043613773 22.377472043037415 1.5124053955078125 5.015069484710693 1.394410297341612 1.7380040884017944 33.33653867221956 72.40866132778044 24.384599570343116 45.66724487410133 37.3656006251034 206.57986604156326 UP 0.7777777777777778 0.2222222222222222 0.0 GO:0008152 2 metabolic process 1361 1509 81 79 70 79 67 67 29 1442 1009 0.98879 0.019549 0.034137 4.44 29142;286954;365813;360243;360268;64305;78968;24950;299270;293820;24679;298490;25664;313245;296371;363465;65035;680308;362094;291234;24552;316273;315994;293502;24484;25685;63868;313200;364975;65030;25315;171142;291075;29740;64526;117543;114027;25427;50549;266682;65210;25086;24303;499353;171521;29277;24894;311849;25413;297594;64515;25599;362485;114494;25612;25649;155423;502970;65155;26760;24763;50681;681337;314304;192272;50559;170465 vnn1;ugt2b1;trim59;top2a;sult1e1;sult1b1;srebf1;srd5a1;serpina6;psat1;prkar2b;ppcs;pparg;polr1e;pltp;pir;nr1i3;mthfd2;mrps2;mki67;me1;mcm3;mapkapk3;kif22;igfbp3;igfbp1;hspd1;hsdl2;gcdh;ephx2;ephx1;ehhadh;eci2;eci1;ech1;decr1;dao;cyp51;cyp4a1;cyp3a2;cyp2j4;cyp2e1;cyp2d3;cyp2c24;cyp2c13;cyp2c11;cyp2a1;crat;cpt2;cdca3;cdc20;cd74;ccne2;ccna2;asns;apoa2;anxa7;angptl3;alas1;akr7a3;acsm3;acox1;acot4;acot3;acot2;acot1;acaa2 VNN1_10157;UGT2B10_33303,UGT2B1_33224;TRIM59_10085;TOP2A_10059;SULT1E1_32446;SULT1B1_32942;SREBF1_32750;SRD5A1_32503;SERPINA6_32325;PSAT1_9583;PRKAR2B_33052;PPCS_9540;PPARG_32510;POLR1E_9523;PLTP_32412;PIR_9487;NR1I3_32602;MTHFD2_9261;MRPS2_9250;MKI67_9232;ME1_9215;MCM3_9207;MAPKAPK3_9194;KIF22_8963;IGFBP3_8881;IGFBP1_32306;HSPD1_8849;HSDL2_8837;GCDH_8693;EPHX2_33282;EPHX1_8567;EHHADH_8534;ECI2_8521;ECI1_8520;ECH1_8516;DECR1_8458;DAO_8437;CYP51_8429;CYP4A1_33111;CYP3A2_32374;CYP2J4_32580;CYP2E1_8421;CYP2D3_8420;CYP2C24_32875;CYP2C13_8419;CYP2C11_32593;CYP2A1_32717;CRAT_8375;CPT2_8374;CDCA3_8260;CDC20_8255;CD74_8252;CCNE2_8227;CCNA2_8221;ASNS_8091;APOA2_33095;ANXA7_8051;ANGPTL3_8045;ALAS1_8018;AKR7A3_8015;ACSM3_7976;ACOX1_7973;ACOT4_7971;ACOT3_7970;ACOT2_7969;ACOT1_7968;ACAA2_7955 25664(0.0441) 42.52114328358209 34.4455 3.54778 29.09720867001592 43.400455931953516 28.94359725708146 27.833117985074622 24.8356 1.51564 17.6263234090616 28.280030676645737 17.67917759999947 83.38827462686565 55.8619 8.55785 87.28081637358652 81.38677033075173 81.61104468548902 20.7328;12.54415;56.1278;54.9577;59.2729;15.4629;41.2009;29.2087;68.3847;26.3316;108.746;15.1091;60.1903;73.982;87.0256;52.1607;22.095;57.4184;63.3158;49.7822;49.3339;54.0045;104.193;73.9175;50.946;98.8371;34.4455;46.9509;15.9021;6.44145;34.0134;7.29984;8.72912;11.7653;9.87438;21.6199;6.1336;75.1522;23.208;23.2485;16.3155;7.89174;12.8059;58.9435;104.635;54.426;9.37187;8.98517;31.2175;46.7245;101.569;94.9138;77.8893;52.8265;28.1893;3.54778;64.7676;58.0729;27.1843;18.819;52.2057;23.8014;12.3157;30.8838;13.6362;28.5134;78.3988 16.8296;7.348245;33.6269;18.8326;45.3114;7.69418;31.4864;22.9308;36.9679;20.9188;59.3814;7.94061;43.9036;47.589;56.6266;40.9644;12.9529;46.387;45.3429;35.6665;35.4173;33.259;59.1667;47.5608;36.3081;57.328;26.6907;34.073;10.4227;2.66377;26.1579;5.26587;5.10151;8.40998;6.59127;17.4928;2.43617;48.098;18.863;18.6955;8.2378;4.16797;8.8664;48.1505;49.2461;43.9518;4.95906;1.97988;24.8356;21.1123;51.5499;58.8146;49.2672;37.3288;23.1774;1.51564;43.3787;40.0757;21.5215;11.5469;42.2655;19.0993;6.70485;24.6874;11.3249;24.741;43.6084 26.7838;25.495849999999997;121.883;218.525;91.5578;35.0879;60.0774;39.9852;89.5095;35.2954;147.467;30.6311;101.057;165.722;104.563;74.9097;55.8619;79.7903;111.245;82.1147;80.9924;111.753;434.985;165.416;85.0816;357.409;48.4857;75.2094;31.2818;17.3473;48.3681;11.8779;17.7951;18.8402;19.44;28.0829;16.2027;171.379;29.9853;30.5145;36.8422;15.8079;22.6004;80.4167;108.327;74.8861;19.1079;31.3726;42.0237;127.486;453.17;118.773;185.461;90.0448;35.9474;8.55785;127.439;105.112;36.6615;51.6405;71.1126;31.3543;24.3993;41.2585;16.9658;33.4642;98.7727 54 14 53 29142;286954;360268;64305;78968;299270;293820;24679;298490;25664;313245;296371;363465;65035;680308;362094;24552;25685;63868;313200;364975;65030;25315;171142;291075;29740;64526;117543;114027;50549;266682;65210;25086;24303;499353;171521;29277;24894;311849;25413;25599;25612;25649;155423;502970;65155;26760;24763;50681;681337;314304;192272;50559 VNN1_10157;UGT2B10_33303,UGT2B1_33224;SULT1E1_32446;SULT1B1_32942;SREBF1_32750;SERPINA6_32325;PSAT1_9583;PRKAR2B_33052;PPCS_9540;PPARG_32510;POLR1E_9523;PLTP_32412;PIR_9487;NR1I3_32602;MTHFD2_9261;MRPS2_9250;ME1_9215;IGFBP1_32306;HSPD1_8849;HSDL2_8837;GCDH_8693;EPHX2_33282;EPHX1_8567;EHHADH_8534;ECI2_8521;ECI1_8520;ECH1_8516;DECR1_8458;DAO_8437;CYP4A1_33111;CYP3A2_32374;CYP2J4_32580;CYP2E1_8421;CYP2D3_8420;CYP2C24_32875;CYP2C13_8419;CYP2C11_32593;CYP2A1_32717;CRAT_8375;CPT2_8374;CD74_8252;ASNS_8091;APOA2_33095;ANXA7_8051;ANGPTL3_8045;ALAS1_8018;AKR7A3_8015;ACSM3_7976;ACOX1_7973;ACOT4_7971;ACOT3_7970;ACOT2_7969;ACOT1_7968 36.66450754716981 27.1843 28.17720855237103 25.028356698113203 21.5215 17.86673198910922 60.39542264150944 36.8422 56.30509848214796 20.7328;12.54415;59.2729;15.4629;41.2009;68.3847;26.3316;108.746;15.1091;60.1903;73.982;87.0256;52.1607;22.095;57.4184;63.3158;49.3339;98.8371;34.4455;46.9509;15.9021;6.44145;34.0134;7.29984;8.72912;11.7653;9.87438;21.6199;6.1336;23.208;23.2485;16.3155;7.89174;12.8059;58.9435;104.635;54.426;9.37187;8.98517;31.2175;94.9138;28.1893;3.54778;64.7676;58.0729;27.1843;18.819;52.2057;23.8014;12.3157;30.8838;13.6362;28.5134 16.8296;7.348245;45.3114;7.69418;31.4864;36.9679;20.9188;59.3814;7.94061;43.9036;47.589;56.6266;40.9644;12.9529;46.387;45.3429;35.4173;57.328;26.6907;34.073;10.4227;2.66377;26.1579;5.26587;5.10151;8.40998;6.59127;17.4928;2.43617;18.863;18.6955;8.2378;4.16797;8.8664;48.1505;49.2461;43.9518;4.95906;1.97988;24.8356;58.8146;23.1774;1.51564;43.3787;40.0757;21.5215;11.5469;42.2655;19.0993;6.70485;24.6874;11.3249;24.741 26.7838;25.495849999999997;91.5578;35.0879;60.0774;89.5095;35.2954;147.467;30.6311;101.057;165.722;104.563;74.9097;55.8619;79.7903;111.245;80.9924;357.409;48.4857;75.2094;31.2818;17.3473;48.3681;11.8779;17.7951;18.8402;19.44;28.0829;16.2027;29.9853;30.5145;36.8422;15.8079;22.6004;80.4167;108.327;74.8861;19.1079;31.3726;42.0237;118.773;35.9474;8.55785;127.439;105.112;36.6615;51.6405;71.1126;31.3543;24.3993;41.2585;16.9658;33.4642 14 365813;360243;24950;291234;316273;315994;293502;24484;25427;297594;64515;362485;114494;170465 TRIM59_10085;TOP2A_10059;SRD5A1_32503;MKI67_9232;MCM3_9207;MAPKAPK3_9194;KIF22_8963;IGFBP3_8881;CYP51_8429;CDCA3_8260;CDC20_8255;CCNE2_8227;CCNA2_8221;ACAA2_7955 64.69269285714286 55.54275 21.29116465887867 38.45114285714286 36.81845 12.123041546049935 170.43264285714287 124.6845 125.21878743599578 56.1278;54.9577;29.2087;49.7822;54.0045;104.193;73.9175;50.946;75.1522;46.7245;101.569;77.8893;52.8265;78.3988 33.6269;18.8326;22.9308;35.6665;33.259;59.1667;47.5608;36.3081;48.098;21.1123;51.5499;49.2672;37.3288;43.6084 121.883;218.525;39.9852;82.1147;111.753;434.985;165.416;85.0816;171.379;127.486;453.17;185.461;90.0448;98.7727 0 Exp 2,20(0.3);Exp 4,6(0.09);Hill,8(0.12);Linear,22(0.33);Poly 2,10(0.15);Power,2(0.03) 2.1067183468384796 191.873974442482 1.5084086656570435 50.888092041015625 5.96019782273412 1.84850013256073 35.55375524513287 49.488531322031285 23.612457636692625 32.05377833345661 62.48869890178716 104.28785035194417 UP 0.7910447761194029 0.208955223880597 0.0 GO:0001523 8 retinoid metabolic process 16 19 4 4 2 4 2 2 94 17 2434 0.96756 0.15902 0.15902 10.53 65210;499353 cyp2j4;cyp2c24 CYP2J4_32580;CYP2C24_32875 37.6295 37.6295 16.3155 30.142547868420145 35.10277241294147 29.92999310727609 28.19415 28.19415 8.2378 28.22254082546432 25.82836881946159 28.023525286027475 58.629450000000006 58.629450000000006 36.8422 30.811824436813215 56.04661967152383 30.594550170146448 0.0 16.3155 0.5 37.6295 16.3155;58.9435 8.2378;48.1505 36.8422;80.4167 2 0 2 65210;499353 CYP2J4_32580;CYP2C24_32875 37.6295 37.6295 30.142547868420145 28.19415 28.19415 28.22254082546432 58.629450000000006 58.629450000000006 30.811824436813215 16.3155;58.9435 8.2378;48.1505 36.8422;80.4167 0 0 Exp 2,1(0.5);Exp 4,1(0.5) 2.287189185277327 4.636326432228088 1.940477728843689 2.6958487033843994 0.5341279384092273 2.318163216114044 -4.145939999999996 79.40494 -10.920296 67.308596 15.92644 101.33246000000001 UP 1.0 0.0 0.0 GO:1901654 5 response to ketone 140 154 7 7 4 6 4 4 92 150 2301 0.29916 0.84414 0.6596 2.6 286954;78968;24950;25664 ugt2b1;srebf1;srd5a1;pparg UGT2B10_33303,UGT2B1_33224;SREBF1_32750;SRD5A1_32503;PPARG_32510 25664(0.0441) 35.7860125 35.2048 12.54415 20.06934201887608 39.66957814915786 20.019638827773836 26.41726125 27.2086 7.348245 15.354163423829805 29.282747185270942 15.207794100586085 56.6538625 50.0313 25.495849999999997 32.82288470638981 63.16271053516078 33.22435273018963 12.54415;41.2009;29.2087;60.1903 7.348245;31.4864;22.9308;43.9036 25.495849999999997;60.0774;39.9852;101.057 4 1 3 286954;78968;25664 UGT2B10_33303,UGT2B1_33224;SREBF1_32750;PPARG_32510 37.97845 41.2009 23.985975912134574 27.579415 31.4864 18.588219216392808 62.21008333333333 60.0774 37.82569366159508 12.54415;41.2009;60.1903 7.348245;31.4864;43.9036 25.495849999999997;60.0774;101.057 1 24950 SRD5A1_32503 29.2087 29.2087 22.9308 22.9308 39.9852 39.9852 29.2087 22.9308 39.9852 0 Exp 2,2(0.4);Exp 4,1(0.2);Linear,1(0.2);Poly 2,1(0.2) 1.7430194083444874 8.752936005592346 1.5239794254302979 1.9512832164764404 0.1813754951046008 1.729828953742981 16.11805732150144 55.45396767849856 11.370181094646796 41.4643414053532 24.487435487737983 88.82028951226202 UP 0.75 0.25 0.0 GO:0008283 3 cell population proliferation 139 149 6 6 5 6 5 5 91 144 2307 0.50413 0.67227 1.0 3.36 291234;24484;63868;25599;155423 mki67;igfbp3;hspd1;cd74;anxa7 MKI67_9232;IGFBP3_8881;HSPD1_8849;CD74_8252;ANXA7_8051 58.971019999999996 50.946 34.4455 22.780585287081653 62.76953453641582 26.675891691162985 40.17172000000001 36.3081 26.6907 11.987536886366595 42.09276354781344 14.010396130316792 92.3788 85.0816 48.4857 31.666530130170525 91.58924833481528 31.63972674249244 49.7822;50.946;34.4455;94.9138;64.7676 35.6665;36.3081;26.6907;58.8146;43.3787 82.1147;85.0816;48.4857;118.773;127.439 3 2 3 63868;25599;155423 HSPD1_8849;CD74_8252;ANXA7_8051 64.70896666666665 64.7676 30.234192640507782 42.961333333333336 43.3787 16.066016432312413 98.23256666666667 118.773 43.299398914573075 34.4455;94.9138;64.7676 26.6907;58.8146;43.3787 48.4857;118.773;127.439 2 291234;24484 MKI67_9232;IGFBP3_8881 50.3641 50.3641 0.8229308719449693 35.987300000000005 35.987300000000005 0.45367971080853614 83.59815 83.59815 2.0979151091016965 49.7822;50.946 35.6665;36.3081 82.1147;85.0816 0 Exp 2,1(0.2);Linear,3(0.6);Poly 2,1(0.2) 1.7656586789244537 8.910982728004456 1.5738487243652344 2.285626173019409 0.2873490214881165 1.6577342748641968 39.00295659049474 78.93908340950526 29.664180634604858 50.67925936539514 64.62186251881822 120.1357374811818 UP 0.6 0.4 0.0 GO:0071456 5 cellular response to hypoxia 57 60 2 2 2 2 2 2 94 58 2393 0.60424 0.66936 1.0 3.33 114494;170465 ccna2;acaa2 CCNA2_8221;ACAA2_7955 65.61265 65.61265 52.8265 18.08234674053671 69.40335361760658 17.269406353778667 40.4686 40.4686 37.3288 4.440347743139048 41.39945496561211 4.240720003253106 94.40875 94.40875 90.0448 6.171557275518077 95.70252811554332 5.8940983687487725 52.8265;78.3988 37.3288;43.6084 90.0448;98.7727 0 2 0 2 114494;170465 CCNA2_8221;ACAA2_7955 65.61265 65.61265 18.08234674053671 40.4686 40.4686 4.440347743139048 94.40875 94.40875 6.171557275518077 52.8265;78.3988 37.3288;43.6084 90.0448;98.7727 0 Linear,1(0.5);Poly 2,1(0.5) 2.0050520290038616 4.0542861223220825 1.72868812084198 2.3255980014801025 0.4220790243564691 2.0271430611610413 40.55179600000001 90.673504 34.314592 46.62260800000001 85.855408 102.962092 DOWN 0.0 1.0 0.0 GO:0050777 6 negative regulation of immune response 45 49 4 4 3 4 3 3 93 46 2405 0.88927 0.28061 0.43004 6.12 309607;25664;25649 rt1-ce5;pparg;apoa2 RT1-CE5_32445;PPARG_32510;APOA2_33095 25664(0.0441) 39.519560000000006 54.8206 3.54778 31.26795702950226 42.10316553384913 30.39306525676064 24.003146666666666 26.5902 1.51564 21.312072211601883 26.4311655377176 21.451451864797342 85.81295 101.057 8.55785 70.87348537540328 87.9660293786267 66.7261481471699 1.5 57.505449999999996 54.8206;60.1903;3.54778 26.5902;43.9036;1.51564 147.824;101.057;8.55785 2 1 2 25664;25649 PPARG_32510;APOA2_33095 31.869040000000002 31.869040000000002 40.05230999549464 22.709619999999997 22.709619999999997 29.972813956664126 54.807425 54.807425 65.40677621899164 60.1903;3.54778 43.9036;1.51564 101.057;8.55785 1 309607 RT1-CE5_32445 54.8206 54.8206 26.5902 26.5902 147.824 147.824 54.8206 26.5902 147.824 0 Exp 2,2(0.67);Hill,1(0.34) 1.6939183671647955 5.097772598266602 1.5239794254302979 1.8475407361984253 0.16346107819052813 1.7262524366378784 4.136535720334145 74.90258427966586 -0.11373336491323727 48.12002669824657 5.6120513146036615 166.01384868539634 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0001934 9 positive regulation of protein phosphorylation 270 289 10 10 6 9 6 6 90 283 2168 0.06726 0.97014 0.13781 2.08 24484;29455;299626;58868;25599;81633 igfbp3;gdf15;gadd45b;fzd1;cd74;acta2 IGFBP3_8881;GDF15_33113;GADD45B_8679;FZD1_8671;CD74_8252;ACTA2_33040 55.8973 51.7589 21.3654 31.234992843732172 63.82226095168463 28.683561413977046 39.0248 36.74995 13.6792 22.215643022068942 43.684316764150374 20.22299603295811 92.46606666666666 96.465 26.3528 36.84177011918222 101.85200224212512 24.264310166528173 50.946;21.3654;52.5718;25.231;94.9138;90.3558 36.3081;17.8875;37.1918;13.6792;58.8146;70.2676 85.0816;26.3528;89.36;131.659;118.773;103.57 4 2 4 29455;299626;58868;25599 GDF15_33113;GADD45B_8679;FZD1_8671;CD74_8252 48.5205 38.9014 33.90453058633905 31.893275 27.53965 20.661932536168212 91.5362 104.06649999999999 46.92296465513092 21.3654;52.5718;25.231;94.9138 17.8875;37.1918;13.6792;58.8146 26.3528;89.36;131.659;118.773 2 24484;81633 IGFBP3_8881;ACTA2_33040 70.65090000000001 70.65090000000001 27.866936825205553 53.287850000000006 53.287850000000006 24.01299273570454 94.32579999999999 94.32579999999999 13.07327301328945 50.946;90.3558 36.3081;70.2676 85.0816;103.57 0 Exp 2,1(0.17);Linear,2(0.34);Poly 2,3(0.5) 1.9460444707414757 13.076640248298645 1.5124053955078125 5.015069484710693 1.3914362536114224 1.62917959690094 30.90410043503487 80.89049956496513 21.248583360782423 56.80101663921758 62.986510915781885 121.94562241755145 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0031348 6 negative regulation of defense response 64 68 5 5 4 5 4 4 92 64 2387 0.88923 0.25268 0.32345 5.88 84386;309607;25664;259241 slpi;rt1-ce5;pparg;nr1d2 SLPI_9890;RT1-CE5_32445;PPARG_32510;NR1D2_9358 25664(0.0441) 66.9443 57.505449999999996 53.7429 21.57117085726534 61.885003796771834 16.86458129494709 37.717175 40.18745 26.5902 7.863484388986463 37.81640233675715 7.556776140464253 111.0655 101.94749999999999 92.543 24.914066689322368 108.96432798972853 24.58537191931379 2.5 79.60685 53.7429;54.8206;60.1903;99.0234 37.8192;26.5902;43.9036;42.5557 92.543;147.824;101.057;102.838 2 2 2 25664;259241 PPARG_32510;NR1D2_9358 79.60685 79.60685 27.45914834449535 43.22965 43.22965 0.9531092303614551 101.94749999999999 101.94749999999999 1.2593571772946877 60.1903;99.0234 43.9036;42.5557 101.057;102.838 2 84386;309607 SLPI_9890;RT1-CE5_32445 54.28175 54.28175 0.7620489780842511 32.2047 32.2047 7.9401020459437515 120.18350000000001 120.18350000000001 39.08956997077355 53.7429;54.8206 37.8192;26.5902 92.543;147.824 0 Exp 2,2(0.5);Linear,1(0.25);Power,1(0.25) 1.904678088062931 7.812607765197754 1.5239794254302979 2.7270524501800537 0.5327418420857104 1.7807879447937012 45.804552559879966 88.08404744012003 30.0109602987933 45.42338970120671 86.64971464446413 135.48128535553587 CONFLICT 0.5 0.5 0.0 GO:0033036 3 macromolecule localization 295 315 8 8 6 8 6 6 90 309 2142 0.03673 0.98502 0.079874 1.9 361604;78968;25664;63868;24471;25599 sytl2;srebf1;pparg;hspd1;hspb1;cd74 SYTL2_32351;SREBF1_32750;PPARG_32510;HSPD1_8849;HSPB1_8847;CD74_8252 25664(0.0441) 56.565333333333335 50.911249999999995 34.4455 22.544059209704606 58.133495185083376 22.66170419229131 39.38033333333333 37.695 26.6907 11.98453327045601 40.340702485339925 11.959315440862056 87.92645 82.1883 48.4857 35.656258008363665 89.91958154434671 34.695873562776356 67.0093;41.2009;60.1903;34.4455;41.6322;94.9138 44.4373;31.4864;43.9036;26.6907;30.9494;58.8146 135.846;60.0774;101.057;48.4857;63.3196;118.773 5 1 5 78968;25664;63868;24471;25599 SREBF1_32750;PPARG_32510;HSPD1_8849;HSPB1_8847;CD74_8252 54.47654 41.6322 24.547307900114017 38.368939999999995 31.4864 13.109707227013129 78.34254000000001 63.3196 30.005431796393104 41.2009;60.1903;34.4455;41.6322;94.9138 31.4864;43.9036;26.6907;30.9494;58.8146 60.0774;101.057;48.4857;63.3196;118.773 1 361604 SYTL2_32351 67.0093 67.0093 44.4373 44.4373 135.846 135.846 67.0093 44.4373 135.846 0 Exp 2,3(0.5);Linear,2(0.34);Poly 2,1(0.17) 1.6782493262678595 10.10905385017395 1.512166976928711 1.912555456161499 0.16454355981255667 1.6567518711090088 38.52632901367644 74.60433765299024 29.79070950277827 48.969957163888395 59.395501502544306 116.4573984974557 UP 0.8333333333333334 0.16666666666666666 0.0 GO:0007093 7 mitotic cell cycle checkpoint 35 38 4 4 2 4 2 2 94 36 2415 0.82951 0.42312 0.65285 5.26 257644;360243 zwint;top2a ZWINT_10214;TOP2A_10059 57.012 57.012 54.9577 2.9052189211829464 57.57713001334275 2.7931260472880672 29.70615 29.70615 18.8326 15.377521881141977 32.697421701593285 14.784206655059117 163.3565 163.3565 108.188 78.02004091578003 148.1798582528844 75.00977186380058 0.5 57.012 59.0663;54.9577 40.5797;18.8326 108.188;218.525 1 1 1 257644 ZWINT_10214 59.0663 59.0663 40.5797 40.5797 108.188 108.188 59.0663 40.5797 108.188 1 360243 TOP2A_10059 54.9577 54.9577 18.8326 18.8326 218.525 218.525 54.9577 18.8326 218.525 0 Exp 2,1(0.5);Linear,1(0.5) 1.682791611222812 3.374002695083618 1.5678966045379639 1.8061060905456543 0.1684395428989999 1.687001347541809 52.985572000000005 61.038427999999996 8.393992 51.018308000000005 55.226240000000004 271.48676 CONFLICT 0.5 0.5 0.0 GO:0048585 5 negative regulation of response to stimulus 377 396 17 17 13 17 13 13 83 383 2068 0.35082 0.75183 0.66786 3.28 29142;365813;84386;309607;25664;259241;24471;29455;58868;65210;25599;25649;170465 vnn1;trim59;slpi;rt1-ce5;pparg;nr1d2;hspb1;gdf15;fzd1;cyp2j4;cd74;apoa2;acaa2 VNN1_10157;TRIM59_10085;SLPI_9890;RT1-CE5_32445;PPARG_32510;NR1D2_9358;HSPB1_8847;GDF15_33113;FZD1_8671;CYP2J4_32580;CD74_8252;APOA2_33095;ACAA2_7955 25664(0.0441) 48.15709846153846 53.7429 3.54778 30.295777987084236 51.01911353228377 29.096337582830166 28.924441538461533 30.9494 1.51564 16.607482721816424 31.06275976187137 17.363325013072295 82.86199615384615 98.7727 8.55785 45.50577440317539 88.45111667601503 42.07931720364722 20.7328;56.1278;53.7429;54.8206;60.1903;99.0234;41.6322;21.3654;25.231;16.3155;94.9138;3.54778;78.3988 16.8296;33.6269;37.8192;26.5902;43.9036;42.5557;30.9494;17.8875;13.6792;8.2378;58.8146;1.51564;43.6084 26.7838;121.883;92.543;147.824;101.057;102.838;63.3196;26.3528;131.659;36.8422;118.773;8.55785;98.7727 9 4 9 29142;25664;259241;24471;29455;58868;65210;25599;25649 VNN1_10157;PPARG_32510;NR1D2_9358;HSPB1_8847;GDF15_33113;FZD1_8671;CYP2J4_32580;CD74_8252;APOA2_33095 42.550242222222224 25.231 34.780350788161186 26.041448888888883 17.8875 19.080748823670714 68.46480555555556 63.3196 45.95408191480683 20.7328;60.1903;99.0234;41.6322;21.3654;25.231;16.3155;94.9138;3.54778 16.8296;43.9036;42.5557;30.9494;17.8875;13.6792;8.2378;58.8146;1.51564 26.7838;101.057;102.838;63.3196;26.3528;131.659;36.8422;118.773;8.55785 4 365813;84386;309607;170465 TRIM59_10085;SLPI_9890;RT1-CE5_32445;ACAA2_7955 60.772525 55.474199999999996 11.791240810413738 35.411175 35.72305 7.164410171756418 115.255675 110.32785 25.114214437694518 56.1278;53.7429;54.8206;78.3988 33.6269;37.8192;26.5902;43.6084 121.883;92.543;147.824;98.7727 0 Exp 2,4(0.31);Exp 4,1(0.08);Hill,1(0.08);Linear,3(0.24);Poly 2,3(0.24);Power,1(0.08) 2.0656810817728233 29.377404928207397 1.5124053955078125 5.015069484710693 1.1772202697339407 1.72868812084198 31.688125947191494 64.62607097588543 19.896511092354846 37.95237198456823 58.124775402840214 107.59921690485211 UP 0.6923076923076923 0.3076923076923077 0.0 GO:0060400 7 negative regulation of growth hormone receptor signaling pathway 1 1 1 1 1 1 1 1 95 0 2451 1.0 0.037691 0.037691 100.0 29455 gdf15 GDF15_33113 21.3654 21.3654 21.3654 21.3654 17.8875 17.8875 17.8875 17.8875 26.3528 26.3528 26.3528 26.3528 0.0 21.3654 0.0 21.3654 21.3654 17.8875 26.3528 1 0 1 29455 GDF15_33113 21.3654 21.3654 17.8875 17.8875 26.3528 26.3528 21.3654 17.8875 26.3528 0 0 Exp 2,1(1) 5.015069484710693 5.015069484710693 5.015069484710693 5.015069484710693 0.0 5.015069484710693 21.3654 21.3654 17.8875 17.8875 26.3528 26.3528 UP 1.0 0.0 0.0 GO:0019395 7 fatty acid oxidation 39 43 12 12 11 12 11 11 85 32 2419 1.0 2.5995E-7 2.5995E-7 25.58 25664;364975;171142;291075;29740;64526;117543;311849;25413;50681;170465 pparg;gcdh;ehhadh;eci2;eci1;ech1;decr1;crat;cpt2;acox1;acaa2 PPARG_32510;GCDH_8693;EHHADH_8534;ECI2_8521;ECI1_8520;ECH1_8516;DECR1_8458;CRAT_8375;CPT2_8374;ACOX1_7973;ACAA2_7955 25664(0.0441) 25.253073636363638 15.9021 7.29984 23.370556261338006 29.075340409833295 26.003437970740386 16.973719090909093 10.4227 1.97988 14.926849770519866 19.25190757761355 16.630026471882342 39.26347272727273 31.2818 11.8779 31.147842542753764 45.29164294222851 35.08996025161653 1.5 8.857145 3.5 10.81984 60.1903;15.9021;7.29984;8.72912;11.7653;9.87438;21.6199;8.98517;31.2175;23.8014;78.3988 43.9036;10.4227;5.26587;5.10151;8.40998;6.59127;17.4928;1.97988;24.8356;19.0993;43.6084 101.057;31.2818;11.8779;17.7951;18.8402;19.44;28.0829;31.3726;42.0237;31.3543;98.7727 10 1 10 25664;364975;171142;291075;29740;64526;117543;311849;25413;50681 PPARG_32510;GCDH_8693;EHHADH_8534;ECI2_8521;ECI1_8520;ECH1_8516;DECR1_8458;CRAT_8375;CPT2_8374;ACOX1_7973 19.938501 13.8337 16.175818529360733 14.310251 9.41634 12.683154141855905 33.31255 29.68235 25.39990815168214 60.1903;15.9021;7.29984;8.72912;11.7653;9.87438;21.6199;8.98517;31.2175;23.8014 43.9036;10.4227;5.26587;5.10151;8.40998;6.59127;17.4928;1.97988;24.8356;19.0993 101.057;31.2818;11.8779;17.7951;18.8402;19.44;28.0829;31.3726;42.0237;31.3543 1 170465 ACAA2_7955 78.3988 78.3988 43.6084 43.6084 98.7727 98.7727 78.3988 43.6084 98.7727 0 Exp 2,2(0.19);Hill,4(0.37);Linear,2(0.19);Poly 2,3(0.28) 2.071780051763672 24.44802951812744 1.5239794254302979 3.9502921104431152 0.948943290664546 1.72868812084198 11.441957466266489 39.064189806460774 8.15251458345442 25.79492359836376 20.8562740711789 57.67067138336655 UP 0.9090909090909091 0.09090909090909091 0.0 GO:0051248 7 negative regulation of protein metabolic process 294 313 10 10 7 10 7 7 89 306 2145 0.080347 0.96146 0.15326 2.24 84386;299270;24679;24484;24471;299626;25427 slpi;serpina6;prkar2b;igfbp3;hspb1;gadd45b;cyp51 SLPI_9890;SERPINA6_32325;PRKAR2B_33052;IGFBP3_8881;HSPB1_8847;GADD45B_8679;CYP51_8429 64.45368571428571 53.7429 41.6322 22.549568023684227 59.7962182869389 18.238958960998872 40.9594 37.1918 30.9494 9.592984621586753 38.500537226225795 7.409769488493055 105.52281428571429 89.5095 63.3196 38.689888490682286 93.84325971221328 26.602800135870627 53.7429;68.3847;108.746;50.946;41.6322;52.5718;75.1522 37.8192;36.9679;59.3814;36.3081;30.9494;37.1918;48.098 92.543;89.5095;147.467;85.0816;63.3196;89.36;171.379 4 3 4 299270;24679;24471;299626 SERPINA6_32325;PRKAR2B_33052;HSPB1_8847;GADD45B_8679 67.833675 60.47825 29.402744124471877 41.122625 37.07985 12.511201599733214 97.41402500000001 89.43475000000001 35.56720847732031 68.3847;108.746;41.6322;52.5718 36.9679;59.3814;30.9494;37.1918 89.5095;147.467;63.3196;89.36 3 84386;24484;25427 SLPI_9890;IGFBP3_8881;CYP51_8429 59.94703333333333 53.7429 13.242110195257169 40.74176666666667 37.8192 6.415331826439964 116.33453333333334 92.543 47.815667991290624 53.7429;50.946;75.1522 37.8192;36.3081;48.098 92.543;85.0816;171.379 0 Linear,5(0.72);Poly 2,1(0.15);Power,1(0.15) 1.707278269991082 11.97520625591278 1.5528020858764648 1.8690931797027588 0.11785295647409785 1.714035153388977 47.748731948756955 81.15863947981447 33.852817540916035 48.06598245908397 76.86094378994797 134.1846847814806 CONFLICT 0.5714285714285714 0.42857142857142855 0.0 GO:0035690 5 cellular response to drug 160 174 6 6 4 6 4 4 92 170 2281 0.2021 0.90467 0.40763 2.3 286954;24950;24471;114494 ugt2b1;srd5a1;hspb1;ccna2 UGT2B10_33303,UGT2B1_33224;SRD5A1_32503;HSPB1_8847;CCNA2_8221 34.052887500000004 35.42045 12.54415 17.281844477677275 32.9782760056941 17.329150304958787 24.639311250000002 26.9401 7.348245 12.94527362299356 23.80740291980809 13.18560691357651 54.71136249999999 51.6524 25.495849999999997 28.242754770246695 53.04321762007697 27.37556348458032 12.54415;29.2087;41.6322;52.8265 7.348245;22.9308;30.9494;37.3288 25.495849999999997;39.9852;63.3196;90.0448 3 2 2 286954;24471 UGT2B10_33303,UGT2B1_33224;HSPB1_8847 27.088175 27.088175 20.568357406493345 19.1488225 19.1488225 16.68853674433479 44.407725 44.407725 26.745430114904675 12.54415;41.6322 7.348245;30.9494 25.495849999999997;63.3196 2 24950;114494 SRD5A1_32503;CCNA2_8221 41.0176 41.0176 16.700306536707636 30.129800000000003 30.129800000000003 10.180923435523901 65.015 65.015 35.39748262348606 29.2087;52.8265 22.9308;37.3288 39.9852;90.0448 0 Exp 4,1(0.2);Linear,3(0.6);Poly 2,1(0.2) 1.8835483218655307 9.488847374916077 1.635288953781128 2.3255980014801025 0.26720496931632437 1.8468482494354248 17.116679911876254 50.98909508812374 11.952943099466308 37.325679400533694 27.033462825158242 82.38926217484175 CONFLICT 0.5 0.5 0.0 GO:1904469 7 positive regulation of tumor necrosis factor secretion 9 9 3 3 3 3 3 3 93 6 2445 0.99979 0.0036955 0.0036955 33.33 24614;63868;65210 orm1;hspd1;cyp2j4 ORM1_9400;HSPD1_8849;CYP2J4_32580 25.0043 24.2519 16.3155 9.088388433600315 23.540367224035403 8.704375029954155 18.213933333333333 19.7133 8.2378 9.317373820091865 16.77896926275316 9.219894922382213 38.8953 36.8422 31.358 8.746481665789943 37.78372022622614 8.022625934205843 0.0 16.3155 0.0 16.3155 24.2519;34.4455;16.3155 19.7133;26.6907;8.2378 31.358;48.4857;36.8422 3 0 3 24614;63868;65210 ORM1_9400;HSPD1_8849;CYP2J4_32580 25.0043 24.2519 9.088388433600315 18.213933333333333 19.7133 9.317373820091865 38.8953 36.8422 8.746481665789943 24.2519;34.4455;16.3155 19.7133;26.6907;8.2378 31.358;48.4857;36.8422 0 0 Exp 2,2(0.67);Exp 4,1(0.34) 2.2583836492740845 7.1812098026275635 1.6557694673538208 3.5849626064300537 1.0414073390233072 1.940477728843689 14.719820323067513 35.28877967693249 7.670332298319327 28.75753436834734 28.99772425335631 48.79287574664369 UP 1.0 0.0 0.0 GO:0010604 6 positive regulation of macromolecule metabolic process 704 754 30 29 23 29 22 22 74 732 1719 0.086461 0.94546 0.17109 2.92 360243;78968;309607;25664;54133;24614;65035;259241;24484;63868;24471;29455;299626;58868;65030;65210;306575;64515;25599;114494;25649;81633 top2a;srebf1;rt1-ce5;pparg;pdlim1;orm1;nr1i3;nr1d2;igfbp3;hspd1;hspb1;gdf15;gadd45b;fzd1;ephx2;cyp2j4;ckap2;cdc20;cd74;ccna2;apoa2;acta2 TOP2A_10059;SREBF1_32750;RT1-CE5_32445;PPARG_32510;PDLIM1_9452;ORM1_9400;NR1I3_32602;NR1D2_9358;IGFBP3_8881;HSPD1_8849;HSPB1_8847;GDF15_33113;GADD45B_8679;FZD1_8671;EPHX2_33282;CYP2J4_32580;CKAP2_8324;CDC20_8255;CD74_8252;CCNA2_8221;APOA2_33095;ACTA2_33040 25664(0.0441) 49.092242272727276 51.7589 3.54778 29.119405375199843 48.55782854183794 28.23369332405282 30.885214090909088 31.2179 1.51564 18.069264741575658 31.237603081260417 18.21016806972843 101.79346136363637 89.7024 8.55785 92.80878024750668 97.52138813760942 84.774958378498 54.9577;41.2009;54.8206;60.1903;67.1147;24.2519;22.095;99.0234;50.946;34.4455;41.6322;21.3654;52.5718;25.231;6.44145;16.3155;64.2131;101.569;94.9138;52.8265;3.54778;90.3558 18.8326;31.4864;26.5902;43.9036;47.2419;19.7133;12.9529;42.5557;36.3081;26.6907;30.9494;17.8875;37.1918;13.6792;2.66377;8.2378;43.1133;51.5499;58.8146;37.3288;1.51564;70.2676 218.525;60.0774;147.824;101.057;123.914;31.358;55.8619;102.838;85.0816;48.4857;63.3196;26.3528;89.36;131.659;17.3473;36.8422;125.437;453.17;118.773;90.0448;8.55785;103.57 15 7 15 78968;25664;54133;24614;65035;259241;63868;24471;29455;299626;58868;65030;65210;25599;25649 SREBF1_32750;PPARG_32510;PDLIM1_9452;ORM1_9400;NR1I3_32602;NR1D2_9358;HSPD1_8849;HSPB1_8847;GDF15_33113;GADD45B_8679;FZD1_8671;EPHX2_33282;CYP2J4_32580;CD74_8252;APOA2_33095 40.68937533333333 34.4455 29.250008735185233 26.365613999999997 26.6907 17.29553065218122 67.72025 60.0774 40.776466125586104 41.2009;60.1903;67.1147;24.2519;22.095;99.0234;34.4455;41.6322;21.3654;52.5718;25.231;6.44145;16.3155;94.9138;3.54778 31.4864;43.9036;47.2419;19.7133;12.9529;42.5557;26.6907;30.9494;17.8875;37.1918;13.6792;2.66377;8.2378;58.8146;1.51564 60.0774;101.057;123.914;31.358;55.8619;102.838;48.4857;63.3196;26.3528;89.36;131.659;17.3473;36.8422;118.773;8.55785 7 360243;309607;24484;306575;64515;114494;81633 TOP2A_10059;RT1-CE5_32445;IGFBP3_8881;CKAP2_8324;CDC20_8255;CCNA2_8221;ACTA2_33040 67.09838571428571 54.9577 20.41315752118623 40.57007142857143 37.3288 16.860172797030124 174.80748571428572 125.437 130.9406294237638 54.9577;54.8206;50.946;64.2131;101.569;52.8265;90.3558 18.8326;26.5902;36.3081;43.1133;51.5499;37.3288;70.2676 218.525;147.824;85.0816;125.437;453.17;90.0448;103.57 0 Exp 2,9(0.41);Exp 4,2(0.1);Hill,1(0.05);Linear,5(0.23);Poly 2,4(0.19);Power,1(0.05) 1.9950980818449018 46.21169877052307 1.5124053955078125 5.015069484710693 0.8227042909486001 1.8264771699905396 36.92401722447691 61.26046732097764 23.334548924539806 38.43587925727837 63.01114043523301 140.5757822920397 UP 0.6818181818181818 0.3181818181818182 0.0 GO:0071702 5 organic substance transport 316 335 16 16 12 16 12 12 84 323 2128 0.49856 0.62363 1.0 3.58 117267;83500;503568;25664;296371;63868;24471;25413;25599;25649;114628;140668 slc26a2;slc22a8;slc13a4;pparg;pltp;hspd1;hspb1;cpt2;cd74;apoa2;abcg5;abcc3 SLC26A2_33072;SLC22A8_9848;SLC13A4_9836;PPARG_32510;PLTP_32412;HSPD1_8849;HSPB1_8847;CPT2_8374;CD74_8252;APOA2_33095;ABCG5_7947;ABCC3_7941 25664(0.0441) 49.47679 47.06135 3.54778 25.40759953340588 51.43699164062195 25.83984115969716 34.365786666666665 34.04865 1.51564 15.609639363557214 35.59511545663912 15.854692631322202 75.60056250000001 76.2309 8.55785 37.35533593496581 77.07724690716283 34.768232018229256 54.7452;52.4905;65.6237;60.1903;87.0256;34.4455;41.6322;31.2175;94.9138;3.54778;33.1119;34.7775 38.3503;37.1479;42.6891;43.9036;56.6266;26.6907;30.9494;24.8356;58.8146;1.51564;24.2098;26.6562 95.3373;89.1422;135.744;101.057;104.563;48.4857;63.3196;42.0237;118.773;8.55785;50.4329;49.7705 9 3 9 83500;25664;296371;63868;24471;25413;25599;25649;140668 SLC22A8_9848;PPARG_32510;PLTP_32412;HSPD1_8849;HSPB1_8847;CPT2_8374;CD74_8252;APOA2_33095;ABCC3_7941 48.915631111111104 41.6322 28.596076412843978 34.12669333333333 30.9494 17.64743892376173 69.52139444444444 63.3196 36.01534859534236 52.4905;60.1903;87.0256;34.4455;41.6322;31.2175;94.9138;3.54778;34.7775 37.1479;43.9036;56.6266;26.6907;30.9494;24.8356;58.8146;1.51564;26.6562 89.1422;101.057;104.563;48.4857;63.3196;42.0237;118.773;8.55785;49.7705 3 117267;503568;114628 SLC26A2_33072;SLC13A4_9836;ABCG5_7947 51.160266666666665 54.7452 16.549715860501458 35.08306666666667 38.3503 9.663190071779255 93.83806666666665 95.3373 42.6753057545384 54.7452;65.6237;33.1119 38.3503;42.6891;24.2098 95.3373;135.744;50.4329 0 Exp 2,5(0.42);Hill,1(0.09);Linear,4(0.34);Poly 2,2(0.17) 1.7338536488599394 21.036888122558594 1.5084086656570435 2.5319817066192627 0.29119242897629977 1.6567518711090088 35.10108725852737 63.852492741472616 25.53380176793398 43.19777156539935 54.464791507433006 96.73633349256698 UP 0.75 0.25 0.0 GO:0001666 4 response to hypoxia 168 175 7 7 7 7 7 7 89 168 2283 0.6623 0.49348 0.83632 4.0 54133;24484;63868;114494;65155;192272;170465 pdlim1;igfbp3;hspd1;ccna2;alas1;acot2;acaa2 PDLIM1_9452;IGFBP3_8881;HSPD1_8849;CCNA2_8221;ALAS1_8018;ACOT2_7969;ACAA2_7955 46.36457142857143 50.946 13.6362 22.73249882390951 47.53716377162211 24.56682759665718 32.00347142857142 36.3081 11.3249 12.776760189332606 32.44112410306036 13.92807824731277 71.41801428571428 85.0816 16.9658 38.159114314644356 73.21036862465223 41.26069235356748 67.1147;50.946;34.4455;52.8265;27.1843;13.6362;78.3988 47.2419;36.3081;26.6907;37.3288;21.5215;11.3249;43.6084 123.914;85.0816;48.4857;90.0448;36.6615;16.9658;98.7727 4 3 4 54133;63868;65155;192272 PDLIM1_9452;HSPD1_8849;ALAS1_8018;ACOT2_7969 35.595175 30.8149 22.7137374742504 26.69475 24.106099999999998 15.112689966933972 56.50675 42.5736 46.78103344351568 67.1147;34.4455;27.1843;13.6362 47.2419;26.6907;21.5215;11.3249 123.914;48.4857;36.6615;16.9658 3 24484;114494;170465 IGFBP3_8881;CCNA2_8221;ACAA2_7955 60.72376666666667 52.8265 15.335878604218678 39.08176666666667 37.3288 3.953259936221414 91.29969999999999 90.0448 6.931279485780461 50.946;52.8265;78.3988 36.3081;37.3288;43.6084 85.0816;90.0448;98.7727 0 Exp 2,2(0.29);Linear,4(0.58);Poly 2,1(0.15) 2.0568294604708384 15.39699637889862 1.63596773147583 4.473705768585205 1.030011076958986 1.7380040884017944 29.524100629774228 63.20504222736864 22.538315022387746 41.46862783475511 43.14934680214482 99.68668176928377 CONFLICT 0.5714285714285714 0.42857142857142855 0.0 GO:0032970 5 regulation of actin filament-based process 88 91 4 4 2 4 2 2 94 89 2362 0.32387 0.86644 0.58104 2.2 64159;81633 sptan1;acta2 SPTAN1_9932;ACTA2_33040 68.95385 68.95385 47.5519 30.26692795123086 76.0537423667002 28.552933025655047 52.3414 52.3414 34.4152 25.351475161812587 58.28824552313884 23.91583888405016 90.10485 90.10485 76.6397 19.042597749388076 94.57178482142858 17.9642287796392 47.5519;90.3558 34.4152;70.2676 76.6397;103.57 1 1 1 64159 SPTAN1_9932 47.5519 47.5519 34.4152 34.4152 76.6397 76.6397 47.5519 34.4152 76.6397 1 81633 ACTA2_33040 90.3558 90.3558 70.2676 70.2676 103.57 103.57 90.3558 70.2676 103.57 0 Linear,1(0.5);Poly 2,1(0.5) 1.5527142908300087 3.1068626642227173 1.5062377452850342 1.600624918937683 0.06674181054682028 1.5534313321113586 27.006028000000008 110.90167199999999 17.206048000000003 87.476752 63.71315600000001 116.49654399999999 CONFLICT 0.5 0.5 0.0 GO:0006952 4 defense response 257 279 10 10 8 10 8 8 88 271 2180 0.25828 0.84312 0.50538 2.87 29142;365813;84386;24614;25211;65030;25599;25649 vnn1;trim59;slpi;orm1;lyz2;ephx2;cd74;apoa2 VNN1_10157;TRIM59_10085;SLPI_9890;ORM1_9400;LYZ2_32611;EPHX2_33282;CD74_8252;APOA2_33095 42.198016249999995 38.9974 3.54778 33.659641605720374 47.14038906365906 33.85270685106912 27.527913749999996 26.670099999999998 1.51564 20.92086721212985 30.53883487000713 21.100839742550075 75.29561874999999 61.950500000000005 8.55785 63.824717922033145 85.24390905224678 64.68832068779007 20.7328;56.1278;53.7429;24.2519;77.8257;6.44145;94.9138;3.54778 16.8296;33.6269;37.8192;19.7133;49.2403;2.66377;58.8146;1.51564 26.7838;121.883;92.543;31.358;185.119;17.3473;118.773;8.55785 5 3 5 29142;24614;65030;25599;25649 VNN1_10157;ORM1_9400;EPHX2_33282;CD74_8252;APOA2_33095 29.977545999999997 20.7328 37.3746096301029 19.907382000000002 16.8296 23.23187654367851 40.563990000000004 26.7838 44.59456476341034 20.7328;24.2519;6.44145;94.9138;3.54778 16.8296;19.7133;2.66377;58.8146;1.51564 26.7838;31.358;17.3473;118.773;8.55785 3 365813;84386;25211 TRIM59_10085;SLPI_9890;LYZ2_32611 62.56546666666666 56.1278 13.26943774405431 40.2288 37.8192 8.08079166975613 133.18166666666664 121.883 47.310927335377144 56.1278;53.7429;77.8257 33.6269;37.8192;49.2403 121.883;92.543;185.119 0 Exp 2,2(0.25);Exp 4,1(0.13);Hill,1(0.13);Linear,3(0.38);Poly 2,1(0.13) 2.1814526305119144 18.93789029121399 1.528815746307373 4.608505725860596 1.1300401986879733 1.734946846961975 18.87307463492056 65.52295786507943 13.030492417479692 42.02533508252031 31.067345717011584 119.52389178298844 UP 0.625 0.375 0.0 GO:0045596 6 negative regulation of cell differentiation 184 195 5 4 4 5 3 3 93 192 2259 0.054869 0.9823 0.11413 1.54 25664;102551184;25599 pparg;loc102551184;cd74 PPARG_32510;HIST1H4A_32934;CD74_8252 25664(0.0441) 71.14479999999999 60.1903 58.3303 20.605555579745996 75.60879291115312 21.316204454861325 47.64166666666667 43.9036 40.2068 9.851010710243497 50.300332202824414 9.470005712928746 108.57733333333333 105.902 101.057 9.155993683556892 109.37196252640943 10.488780739280426 60.1903;58.3303;94.9138 43.9036;40.2068;58.8146 101.057;105.902;118.773 2 1 2 25664;25599 PPARG_32510;CD74_8252 77.55205 77.55205 24.55322231653108 51.3591 51.3591 10.543669214272617 109.91499999999999 109.91499999999999 12.527103735500948 60.1903;94.9138 43.9036;58.8146 101.057;118.773 1 102551184 HIST1H4A_32934 58.3303 58.3303 40.2068 40.2068 105.902 105.902 58.3303 40.2068 105.902 0 Exp 2,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 1.6111414925319403 4.837129235267639 1.5239794254302979 1.6577342748641968 0.07656281429162867 1.6554155349731445 47.82741880089448 94.46218119910553 36.49419864338262 58.789134689950714 98.21635111424919 118.93831555241746 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0009804 5 coumarin metabolic process 3 5 1 1 1 1 1 1 95 4 2447 0.98695 0.1749 0.1749 20.0 24894 cyp2a1 CYP2A1_32717 9.37187 9.37187 9.37187 9.37187 4.95906 4.95906 4.95906 4.95906 19.1079 19.1079 19.1079 19.1079 0.0 9.37187 0.0 9.37187 9.37187 4.95906 19.1079 1 0 1 24894 CYP2A1_32717 9.37187 9.37187 4.95906 4.95906 19.1079 19.1079 9.37187 4.95906 19.1079 0 0 Exp 4,1(1) 1.7483696937561035 1.7483696937561035 1.7483696937561035 1.7483696937561035 0.0 1.7483696937561035 9.37187 9.37187 4.95906 4.95906 19.1079 19.1079 UP 1.0 0.0 0.0 GO:0008150 1 biological_process 2293 2547 119 117 99 116 96 96 0 2451 0 1.0 1.0 1.0 3.77 257644;29142;286954;365813;360243;25123;361604;360268;64305;78968;24950;64159;84386;117267;83500;503568;299270;309607;293820;24679;308761;298490;25664;313245;296371;363465;54133;24614;304951;338475;65035;259241;680308;362094;291234;24552;316273;315994;25211;25626;293502;303575;24484;25685;63868;24471;313200;25460;102551184;29455;364975;299626;58868;65030;25315;171142;291075;29740;64526;117543;114027;25427;50549;266682;65210;25086;24303;499353;171521;29277;24894;311849;25413;306575;297594;64515;25599;362485;114494;25612;25649;155423;502970;65155;26760;81633;24763;50681;681337;314304;192272;50559;170465;114628;140668;140656 zwint;vnn1;ugt2b1;trim59;top2a;tagln;sytl2;sult1e1;sult1b1;srebf1;srd5a1;sptan1;slpi;slc26a2;slc22a8;slc13a4;serpina6;rt1-ce5;psat1;prkar2b;prc1;ppcs;pparg;polr1e;pltp;pir;pdlim1;orm1;nuf2;nrep;nr1i3;nr1d2;mthfd2;mrps2;mki67;me1;mcm3;mapkapk3;lyz2;krt8;kif22;kif18b;igfbp3;igfbp1;hspd1;hspb1;hsdl2;hmmr;loc102551184;gdf15;gcdh;gadd45b;fzd1;ephx2;ephx1;ehhadh;eci2;eci1;ech1;decr1;dao;cyp51;cyp4a1;cyp3a2;cyp2j4;cyp2e1;cyp2d3;cyp2c24;cyp2c13;cyp2c11;cyp2a1;crat;cpt2;ckap2;cdca3;cdc20;cd74;ccne2;ccna2;asns;apoa2;anxa7;angptl3;alas1;akr7a3;acta2;acsm3;acox1;acot4;acot3;acot2;acot1;acaa2;abcg5;abcc3;a1bg ZWINT_10214;VNN1_10157;UGT2B10_33303,UGT2B1_33224;TRIM59_10085;TOP2A_10059;TAGLN_9981;SYTL2_32351;SULT1E1_32446;SULT1B1_32942;SREBF1_32750;SRD5A1_32503;SPTAN1_9932;SLPI_9890;SLC26A2_33072;SLC22A8_9848;SLC13A4_9836;SERPINA6_32325;RT1-CE5_32445;PSAT1_9583;PRKAR2B_33052;PRC1_9556;PPCS_9540;PPARG_32510;POLR1E_9523;PLTP_32412;PIR_9487;PDLIM1_9452;ORM1_9400;NUF2_33136;NREP_9364;NR1I3_32602;NR1D2_9358;MTHFD2_9261;MRPS2_9250;MKI67_9232;ME1_9215;MCM3_9207;MAPKAPK3_9194;LYZ2_32611;KRT8_8978;KIF22_8963;KIF18B_32882;IGFBP3_8881;IGFBP1_32306;HSPD1_8849;HSPB1_8847;HSDL2_8837;HMMR_8814;HIST1H4A_32934;GDF15_33113;GCDH_8693;GADD45B_8679;FZD1_8671;EPHX2_33282;EPHX1_8567;EHHADH_8534;ECI2_8521;ECI1_8520;ECH1_8516;DECR1_8458;DAO_8437;CYP51_8429;CYP4A1_33111;CYP3A2_32374;CYP2J4_32580;CYP2E1_8421;CYP2D3_8420;CYP2C24_32875;CYP2C13_8419;CYP2C11_32593;CYP2A1_32717;CRAT_8375;CPT2_8374;CKAP2_8324;CDCA3_8260;CDC20_8255;CD74_8252;CCNE2_8227;CCNA2_8221;ASNS_8091;APOA2_33095;ANXA7_8051;ANGPTL3_8045;ALAS1_8018;AKR7A3_8015;ACTA2_33040;ACSM3_7976;ACOX1_7973;ACOT4_7971;ACOT3_7970;ACOT2_7969;ACOT1_7968;ACAA2_7955;ABCG5_7947;ABCC3_7941;A1BG_7930 25664(0.0441) 46.443994791666675 49.55805 5.73955E-13 28.06537489362416 47.7158687457122 27.233605606396726 30.515102135416686 33.84995 5.73955E-13 17.062138770634228 31.36454883751963 16.79937628922982 91.95363333333331 78.215 5.73957E-13 84.7535712405404 91.81550790093411 78.55461761483376 59.0663;20.7328;12.54415;56.1278;54.9577;45.9044;67.0093;59.2729;15.4629;41.2009;29.2087;47.5519;53.7429;54.7452;52.4905;65.6237;68.3847;54.8206;26.3316;108.746;80.3005;15.1091;60.1903;73.982;87.0256;52.1607;67.1147;24.2519;5.73955E-13;69.4104;22.095;99.0234;57.4184;63.3158;49.7822;49.3339;54.0045;104.193;77.8257;68.9539;73.9175;65.9823;50.946;98.8371;34.4455;41.6322;46.9509;103.573;58.3303;21.3654;15.9021;52.5718;25.231;6.44145;34.0134;7.29984;8.72912;11.7653;9.87438;21.6199;6.1336;75.1522;23.208;23.2485;16.3155;7.89174;12.8059;58.9435;104.635;54.426;9.37187;8.98517;31.2175;64.2131;46.7245;101.569;94.9138;77.8893;52.8265;28.1893;3.54778;64.7676;58.0729;27.1843;18.819;90.3558;52.2057;23.8014;12.3157;30.8838;13.6362;28.5134;78.3988;33.1119;34.7775;30.7273 40.5797;16.8296;7.348245;33.6269;18.8326;35.0852;44.4373;45.3114;7.69418;31.4864;22.9308;34.4152;37.8192;38.3503;37.1479;42.6891;36.9679;26.5902;20.9188;59.3814;50.2731;7.94061;43.9036;47.589;56.6266;40.9644;47.2419;19.7133;5.73955E-13;43.1468;12.9529;42.5557;46.387;45.3429;35.6665;35.4173;33.259;59.1667;49.2403;45.3374;47.5608;43.9552;36.3081;57.328;26.6907;30.9494;34.073;58.9579;40.2068;17.8875;10.4227;37.1918;13.6792;2.66377;26.1579;5.26587;5.10151;8.40998;6.59127;17.4928;2.43617;48.098;18.863;18.6955;8.2378;4.16797;8.8664;48.1505;49.2461;43.9518;4.95906;1.97988;24.8356;43.1133;21.1123;51.5499;58.8146;49.2672;37.3288;23.1774;1.51564;43.3787;40.0757;21.5215;11.5469;70.2676;42.2655;19.0993;6.70485;24.6874;11.3249;24.741;43.6084;24.2098;26.6562;22.9336 108.188;26.7838;25.495849999999997;121.883;218.525;67.7714;135.846;91.5578;35.0879;60.0774;39.9852;76.6397;92.543;95.3373;89.1422;135.744;89.5095;147.824;35.2954;147.467;198.961;30.6311;101.057;165.722;104.563;74.9097;123.914;31.358;5.73957E-13;157.944;55.8619;102.838;79.7903;111.245;82.1147;80.9924;111.753;434.985;185.119;143.578;165.416;131.93;85.0816;357.409;48.4857;63.3196;75.2094;424.786;105.902;26.3528;31.2818;89.36;131.659;17.3473;48.3681;11.8779;17.7951;18.8402;19.44;28.0829;16.2027;171.379;29.9853;30.5145;36.8422;15.8079;22.6004;80.4167;108.327;74.8861;19.1079;31.3726;42.0237;125.437;127.486;453.17;118.773;185.461;90.0448;35.9474;8.55785;127.439;105.112;36.6615;51.6405;103.57;71.1126;31.3543;24.3993;41.2585;16.9658;33.4642;98.7727;50.4329;49.7705;45.267 67 30 66 257644;29142;286954;25123;360268;64305;78968;64159;83500;299270;293820;24679;298490;25664;313245;296371;363465;54133;24614;65035;259241;680308;362094;24552;25626;25685;63868;24471;313200;29455;364975;299626;58868;65030;25315;171142;291075;29740;64526;117543;114027;50549;266682;65210;25086;24303;499353;171521;29277;24894;311849;25413;25599;25612;25649;155423;502970;65155;26760;24763;50681;681337;314304;192272;50559;140668 ZWINT_10214;VNN1_10157;UGT2B10_33303,UGT2B1_33224;TAGLN_9981;SULT1E1_32446;SULT1B1_32942;SREBF1_32750;SPTAN1_9932;SLC22A8_9848;SERPINA6_32325;PSAT1_9583;PRKAR2B_33052;PPCS_9540;PPARG_32510;POLR1E_9523;PLTP_32412;PIR_9487;PDLIM1_9452;ORM1_9400;NR1I3_32602;NR1D2_9358;MTHFD2_9261;MRPS2_9250;ME1_9215;KRT8_8978;IGFBP1_32306;HSPD1_8849;HSPB1_8847;HSDL2_8837;GDF15_33113;GCDH_8693;GADD45B_8679;FZD1_8671;EPHX2_33282;EPHX1_8567;EHHADH_8534;ECI2_8521;ECI1_8520;ECH1_8516;DECR1_8458;DAO_8437;CYP4A1_33111;CYP3A2_32374;CYP2J4_32580;CYP2E1_8421;CYP2D3_8420;CYP2C24_32875;CYP2C13_8419;CYP2C11_32593;CYP2A1_32717;CRAT_8375;CPT2_8374;CD74_8252;ASNS_8091;APOA2_33095;ANXA7_8051;ANGPTL3_8045;ALAS1_8018;AKR7A3_8015;ACSM3_7976;ACOX1_7973;ACOT4_7971;ACOT3_7970;ACOT2_7969;ACOT1_7968;ABCC3_7941 39.138693939393946 31.05065 27.31481534313983 26.590050075757574 24.7883 16.926660525333364 65.2249787878788 49.1281 53.714255103344385 59.0663;20.7328;12.54415;45.9044;59.2729;15.4629;41.2009;47.5519;52.4905;68.3847;26.3316;108.746;15.1091;60.1903;73.982;87.0256;52.1607;67.1147;24.2519;22.095;99.0234;57.4184;63.3158;49.3339;68.9539;98.8371;34.4455;41.6322;46.9509;21.3654;15.9021;52.5718;25.231;6.44145;34.0134;7.29984;8.72912;11.7653;9.87438;21.6199;6.1336;23.208;23.2485;16.3155;7.89174;12.8059;58.9435;104.635;54.426;9.37187;8.98517;31.2175;94.9138;28.1893;3.54778;64.7676;58.0729;27.1843;18.819;52.2057;23.8014;12.3157;30.8838;13.6362;28.5134;34.7775 40.5797;16.8296;7.348245;35.0852;45.3114;7.69418;31.4864;34.4152;37.1479;36.9679;20.9188;59.3814;7.94061;43.9036;47.589;56.6266;40.9644;47.2419;19.7133;12.9529;42.5557;46.387;45.3429;35.4173;45.3374;57.328;26.6907;30.9494;34.073;17.8875;10.4227;37.1918;13.6792;2.66377;26.1579;5.26587;5.10151;8.40998;6.59127;17.4928;2.43617;18.863;18.6955;8.2378;4.16797;8.8664;48.1505;49.2461;43.9518;4.95906;1.97988;24.8356;58.8146;23.1774;1.51564;43.3787;40.0757;21.5215;11.5469;42.2655;19.0993;6.70485;24.6874;11.3249;24.741;26.6562 108.188;26.7838;25.495849999999997;67.7714;91.5578;35.0879;60.0774;76.6397;89.1422;89.5095;35.2954;147.467;30.6311;101.057;165.722;104.563;74.9097;123.914;31.358;55.8619;102.838;79.7903;111.245;80.9924;143.578;357.409;48.4857;63.3196;75.2094;26.3528;31.2818;89.36;131.659;17.3473;48.3681;11.8779;17.7951;18.8402;19.44;28.0829;16.2027;29.9853;30.5145;36.8422;15.8079;22.6004;80.4167;108.327;74.8861;19.1079;31.3726;42.0237;118.773;35.9474;8.55785;127.439;105.112;36.6615;51.6405;71.1126;31.3543;24.3993;41.2585;16.9658;33.4642;49.7705 30 365813;360243;361604;24950;84386;117267;503568;309607;308761;304951;338475;291234;316273;315994;25211;293502;303575;24484;25460;102551184;25427;306575;297594;64515;362485;114494;81633;170465;114628;140656 TRIM59_10085;TOP2A_10059;SYTL2_32351;SRD5A1_32503;SLPI_9890;SLC26A2_33072;SLC13A4_9836;RT1-CE5_32445;PRC1_9556;NUF2_33136;NREP_9364;MKI67_9232;MCM3_9207;MAPKAPK3_9194;LYZ2_32611;KIF22_8963;KIF18B_32882;IGFBP3_8881;HMMR_8814;HIST1H4A_32934;CYP51_8429;CKAP2_8324;CDCA3_8260;CDC20_8255;CCNE2_8227;CCNA2_8221;ACTA2_33040;ACAA2_7955;ABCG5_7947;A1BG_7930 62.51565666666669 61.271699999999996 22.788803447060197 39.15021666666669 41.447950000000006 14.1165729934243 150.75667333333337 126.4615 108.90930375043303 56.1278;54.9577;67.0093;29.2087;53.7429;54.7452;65.6237;54.8206;80.3005;5.73955E-13;69.4104;49.7822;54.0045;104.193;77.8257;73.9175;65.9823;50.946;103.573;58.3303;75.1522;64.2131;46.7245;101.569;77.8893;52.8265;90.3558;78.3988;33.1119;30.7273 33.6269;18.8326;44.4373;22.9308;37.8192;38.3503;42.6891;26.5902;50.2731;5.73955E-13;43.1468;35.6665;33.259;59.1667;49.2403;47.5608;43.9552;36.3081;58.9579;40.2068;48.098;43.1133;21.1123;51.5499;49.2672;37.3288;70.2676;43.6084;24.2098;22.9336 121.883;218.525;135.846;39.9852;92.543;95.3373;135.744;147.824;198.961;5.73957E-13;157.944;82.1147;111.753;434.985;185.119;165.416;131.93;85.0816;424.786;105.902;171.379;125.437;127.486;453.17;185.461;90.0448;103.57;98.7727;50.4329;45.267 0 Exp 2,29(0.3);Exp 4,6(0.07);Hill,9(0.1);Linear,38(0.4);Poly 2,12(0.13);Power,3(0.04) 2.0649330916838813 252.72194123268127 1.5062377452850342 50.888092041015625 5.014200206118672 1.8061060905456543 40.82975054410743 52.05823903922593 27.101963532880045 33.9282407379533 74.999388054201 108.90787861246568 UP 0.6875 0.3125 0.0 GO:0010976 8 positive regulation of neuron projection development 73 77 2 2 2 2 2 2 94 75 2376 0.4383 0.79613 1.0 2.6 24471;58868 hspb1;fzd1 HSPB1_8847;FZD1_8671 33.4316 33.4316 25.231 11.597399739596785 34.34014431599229 11.52600430208822 22.3143 22.3143 13.6792 12.21187553244792 23.27098256262042 12.136697284218469 97.4893 97.4893 63.3196 48.323253162219935 93.70363959537572 48.025767529334935 41.6322;25.231 30.9494;13.6792 63.3196;131.659 2 0 2 24471;58868 HSPB1_8847;FZD1_8671 33.4316 33.4316 11.597399739596785 22.3143 22.3143 12.21187553244792 97.4893 97.4893 48.323253162219935 41.6322;25.231 30.9494;13.6792 63.3196;131.659 0 0 Linear,1(0.5);Poly 2,1(0.5) 1.6712819203025846 3.3592536449432373 1.5124053955078125 1.8468482494354248 0.23648680993159663 1.6796268224716187 17.358424000000007 49.504776 5.389503999999995 39.239096 30.516688000000002 164.46191199999998 UP 1.0 0.0 0.0 GO:0050867 6 positive regulation of cell activation 103 110 6 6 5 6 5 5 91 105 2346 0.76788 0.40065 0.60619 4.55 29142;309607;63868;25599;81633 vnn1;rt1-ce5;hspd1;cd74;acta2 VNN1_10157;RT1-CE5_32445;HSPD1_8849;CD74_8252;ACTA2_33040 59.053700000000006 54.8206 20.7328 33.00659879508943 66.56864801363336 30.90392625166995 39.83854 26.6907 16.8296 23.258407484993462 43.77809041633071 22.0691577242813 89.0873 103.57 26.7838 50.17769759933193 100.39382667668401 44.84124389976237 20.7328;54.8206;34.4455;94.9138;90.3558 16.8296;26.5902;26.6907;58.8146;70.2676 26.7838;147.824;48.4857;118.773;103.57 3 2 3 29142;63868;25599 VNN1_10157;HSPD1_8849;CD74_8252 50.0307 34.4455 39.46997636850064 34.11163333333334 26.6907 21.954219296147446 64.68083333333333 48.4857 48.08549663800233 20.7328;34.4455;94.9138 16.8296;26.6907;58.8146 26.7838;48.4857;118.773 2 309607;81633 RT1-CE5_32445;ACTA2_33040 72.5882 72.5882 25.127180890820195 48.4289 48.4289 30.884585724597326 125.697 125.697 31.29230349462951 54.8206;90.3558 26.5902;70.2676 147.824;103.57 0 Exp 2,2(0.4);Linear,1(0.2);Poly 2,2(0.4) 2.0634393246118 11.370175123214722 1.600624918937683 4.608505725860596 1.308358792236793 1.6577342748641968 30.122140544142017 87.985259455858 19.451646967544555 60.225433032455435 45.104608827678604 133.0699911723214 UP 0.6 0.4 0.0 GO:0051128 5 regulation of cellular component organization 515 547 19 19 14 19 14 14 82 533 1918 0.056169 0.96894 0.10019 2.56 360243;78968;64159;25664;291234;24484;25685;24471;29455;58868;306575;64515;25649;170465 top2a;srebf1;sptan1;pparg;mki67;igfbp3;igfbp1;hspb1;gdf15;fzd1;ckap2;cdc20;apoa2;acaa2 TOP2A_10059;SREBF1_32750;SPTAN1_9932;PPARG_32510;MKI67_9232;IGFBP3_8881;IGFBP1_32306;HSPB1_8847;GDF15_33113;FZD1_8671;CKAP2_8324;CDC20_8255;APOA2_33095;ACAA2_7955 25664(0.0441) 52.815955714285714 50.3641 3.54778 27.478616675014425 52.74087443139195 25.11571094084813 32.87455285714286 35.04085 1.51564 15.416397706289843 33.3063161400327 14.541030113698351 134.869525 91.92715 8.55785 126.33264715036853 122.54600487407772 111.62294397290265 54.9577;41.2009;47.5519;60.1903;49.7822;50.946;98.8371;41.6322;21.3654;25.231;64.2131;101.569;3.54778;78.3988 18.8326;31.4864;34.4152;43.9036;35.6665;36.3081;57.328;30.9494;17.8875;13.6792;43.1133;51.5499;1.51564;43.6084 218.525;60.0774;76.6397;101.057;82.1147;85.0816;357.409;63.3196;26.3528;131.659;125.437;453.17;8.55785;98.7727 8 6 8 78968;64159;25664;25685;24471;29455;58868;25649 SREBF1_32750;SPTAN1_9932;PPARG_32510;IGFBP1_32306;HSPB1_8847;GDF15_33113;FZD1_8671;APOA2_33095 42.4445725 41.41655 28.72758387032612 28.895617499999997 31.2179 17.636881248310928 103.13404374999999 69.97965 109.84064508229132 41.2009;47.5519;60.1903;98.8371;41.6322;21.3654;25.231;3.54778 31.4864;34.4152;43.9036;57.328;30.9494;17.8875;13.6792;1.51564 60.0774;76.6397;101.057;357.409;63.3196;26.3528;131.659;8.55785 6 360243;291234;24484;306575;64515;170465 TOP2A_10059;MKI67_9232;IGFBP3_8881;CKAP2_8324;CDC20_8255;ACAA2_7955 66.64446666666667 59.5854 20.155184605819578 38.17980000000001 39.7107 11.10587934240238 177.1835 112.10485 144.37760099159425 54.9577;49.7822;50.946;64.2131;101.569;78.3988 18.8326;35.6665;36.3081;43.1133;51.5499;43.6084 218.525;82.1147;85.0816;125.437;453.17;98.7727 0 Exp 2,5(0.36);Hill,1(0.08);Linear,6(0.43);Poly 2,2(0.15) 1.9410554241129685 28.797156810760498 1.5062377452850342 5.015069484710693 0.9091627180218435 1.7720550894737244 38.4217760458301 67.21013538274134 24.798949887417056 40.95015582686865 68.69243746387647 201.04661253612355 CONFLICT 0.5714285714285714 0.42857142857142855 0.0 GO:0046394 6 carboxylic acid biosynthetic process 88 95 8 8 6 8 6 6 90 89 2362 0.93581 0.14564 0.16986 6.32 293820;50549;29277;25599;25612;24763 psat1;cyp4a1;cyp2c11;cd74;asns;acsm3 PSAT1_9583;CYP4A1_33111;CYP2C11_32593;CD74_8252;ASNS_8091;ACSM3_7976 46.545733333333324 40.1975 23.208 27.29037679019231 57.52491484468973 28.788165181140347 34.66518333333334 32.721450000000004 18.863 16.11112414853993 41.3779926094955 15.805275767847284 60.999966666666666 53.53 29.9853 34.30183325996829 75.196612470813 35.18747992175411 3.5 53.31585 26.3316;23.208;54.426;94.9138;28.1893;52.2057 20.9188;18.863;43.9518;58.8146;23.1774;42.2655 35.2954;29.9853;74.8861;118.773;35.9474;71.1126 6 0 6 293820;50549;29277;25599;25612;24763 PSAT1_9583;CYP4A1_33111;CYP2C11_32593;CD74_8252;ASNS_8091;ACSM3_7976 46.545733333333324 40.1975 27.29037679019231 34.66518333333334 32.721450000000004 16.11112414853993 60.999966666666666 53.53 34.30183325996829 26.3316;23.208;54.426;94.9138;28.1893;52.2057 20.9188;18.863;43.9518;58.8146;23.1774;42.2655 35.2954;29.9853;74.8861;118.773;35.9474;71.1126 0 0 Exp 2,4(0.67);Linear,1(0.17);Poly 2,1(0.17) 2.462272371741279 15.141628623008728 1.6577342748641968 3.2609751224517822 0.586163355396712 2.6194283962249756 24.70888397874038 68.38258268792629 21.773599106792055 47.55676755987461 33.55278368187594 88.4471496514574 UP 1.0 0.0 0.0 GO:0051599 4 response to hydrostatic pressure 6 6 1 1 1 1 1 1 95 5 2446 0.9809 0.20606 0.20606 16.67 25626 krt8 KRT8_8978 68.9539 68.9539 68.9539 68.9539 45.3374 45.3374 45.3374 45.3374 143.578 143.578 143.578 143.578 0.0 68.9539 0.0 68.9539 68.9539 45.3374 143.578 1 0 1 25626 KRT8_8978 68.9539 68.9539 45.3374 45.3374 143.578 143.578 68.9539 45.3374 143.578 0 0 Linear,1(1) 1.5914322137832642 1.5914322137832642 1.5914322137832642 1.5914322137832642 0.0 1.5914322137832642 68.9539 68.9539 45.3374 45.3374 143.578 143.578 UP 1.0 0.0 0.0 GO:0019637 4 organophosphate metabolic process 156 173 15 14 13 15 12 12 84 161 2290 0.98849 0.026872 0.035337 6.94 360268;64305;298490;364975;25649;502970;24763;681337;314304;192272;50559;170465 sult1e1;sult1b1;ppcs;gcdh;apoa2;angptl3;acsm3;acot4;acot3;acot2;acot1;acaa2 SULT1E1_32446;SULT1B1_32942;PPCS_9540;GCDH_8693;APOA2_33095;ANGPTL3_8045;ACSM3_7976;ACOT4_7971;ACOT3_7970;ACOT2_7969;ACOT1_7968;ACAA2_7955 31.94344 22.20775 3.54778 24.02695501426981 35.14922786465686 26.41411641707417 22.191023333333334 18.006149999999998 1.51564 16.694931861686936 23.617544994459372 17.946932561374318 49.01679583333333 34.27605 8.55785 33.49240033091944 55.8845461746892 38.02974384340814 7.5 41.54475 59.2729;15.4629;15.1091;15.9021;3.54778;58.0729;52.2057;12.3157;30.8838;13.6362;28.5134;78.3988 45.3114;7.69418;7.94061;10.4227;1.51564;40.0757;42.2655;6.70485;24.6874;11.3249;24.741;43.6084 91.5578;35.0879;30.6311;31.2818;8.55785;105.112;71.1126;24.3993;41.2585;16.9658;33.4642;98.7727 11 1 11 360268;64305;298490;364975;25649;502970;24763;681337;314304;192272;50559 SULT1E1_32446;SULT1B1_32942;PPCS_9540;GCDH_8693;APOA2_33095;ANGPTL3_8045;ACSM3_7976;ACOT4_7971;ACOT3_7970;ACOT2_7969;ACOT1_7968 27.720225454545457 15.9021 19.98986947190819 20.24398909090909 11.3249 16.017252759119746 44.49353181818182 33.4642 31.04583802845619 59.2729;15.4629;15.1091;15.9021;3.54778;58.0729;52.2057;12.3157;30.8838;13.6362;28.5134 45.3114;7.69418;7.94061;10.4227;1.51564;40.0757;42.2655;6.70485;24.6874;11.3249;24.741 91.5578;35.0879;30.6311;31.2818;8.55785;105.112;71.1126;24.3993;41.2585;16.9658;33.4642 1 170465 ACAA2_7955 78.3988 78.3988 43.6084 43.6084 98.7727 98.7727 78.3988 43.6084 98.7727 0 Exp 2,4(0.34);Exp 4,1(0.09);Hill,3(0.25);Linear,2(0.17);Poly 2,2(0.17) 2.825925081166664 76.20823729038239 1.5375925302505493 50.888092041015625 14.051483850190339 2.1360262632369995 18.3489104336102 45.53796956638979 12.744976396974867 31.6370702696918 30.06668641340755 67.96690525325911 UP 0.9166666666666666 0.08333333333333333 0.0 GO:0006066 4 alcohol metabolic process 93 100 11 10 8 11 7 7 89 93 2358 0.96751 0.079978 0.099815 7.0 360268;64305;78968;25315;25427;25649;502970 sult1e1;sult1b1;srebf1;ephx1;cyp51;apoa2;angptl3 SULT1E1_32446;SULT1B1_32942;SREBF1_32750;EPHX1_8567;CYP51_8429;APOA2_33095;ANGPTL3_8045 40.96042571428571 41.2009 3.54778 25.48008958153983 38.88242248129626 22.878862372138936 28.61988857142857 31.4864 1.51564 18.147740168843267 27.654115122624525 17.437707480662635 74.30572142857143 60.0774 8.55785 53.86078950730189 66.37136920684136 40.52806643749586 4.0 58.0729 59.2729;15.4629;41.2009;34.0134;75.1522;3.54778;58.0729 45.3114;7.69418;31.4864;26.1579;48.098;1.51564;40.0757 91.5578;35.0879;60.0774;48.3681;171.379;8.55785;105.112 6 1 6 360268;64305;78968;25315;25649;502970 SULT1E1_32446;SULT1B1_32942;SREBF1_32750;EPHX1_8567;APOA2_33095;ANGPTL3_8045 35.26179666666666 37.60715 22.50104941357328 25.373536666666666 28.82215 17.51235683997978 58.12684166666666 54.22275 35.81103060061827 59.2729;15.4629;41.2009;34.0134;3.54778;58.0729 45.3114;7.69418;31.4864;26.1579;1.51564;40.0757 91.5578;35.0879;60.0774;48.3681;8.55785;105.112 1 25427 CYP51_8429 75.1522 75.1522 48.098 48.098 171.379 171.379 75.1522 48.098 171.379 0 Exp 2,2(0.29);Exp 4,1(0.15);Hill,1(0.15);Linear,3(0.43) 1.8671815294406438 13.375195264816284 1.5375925302505493 2.9455835819244385 0.4854350132769511 1.7262524366378784 22.08451119769309 59.83634023087835 15.175854514947115 42.06392262791002 34.40509018147443 114.20635267566843 UP 0.8571428571428571 0.14285714285714285 0.0 GO:0051234 3 establishment of localization 596 632 20 20 16 20 16 16 80 616 1835 0.035021 0.981 0.070025 2.53 257644;361604;117267;83500;503568;25664;296371;315994;293502;63868;24471;25413;25599;25649;114628;140668 zwint;sytl2;slc26a2;slc22a8;slc13a4;pparg;pltp;mapkapk3;kif22;hspd1;hspb1;cpt2;cd74;apoa2;abcg5;abcc3 ZWINT_10214;SYTL2_32351;SLC26A2_33072;SLC22A8_9848;SLC13A4_9836;PPARG_32510;PLTP_32412;MAPKAPK3_9194;KIF22_8963;HSPD1_8849;HSPB1_8847;CPT2_8374;CD74_8252;APOA2_33095;ABCG5_7947;ABCC3_7941 25664(0.0441) 56.11922375 56.90575 3.54778 26.313008174142517 57.97631712716824 26.174933609607418 37.758371249999996 39.465 1.51564 15.111489994822652 38.87917104236413 14.981612492677037 109.47760937499999 98.19715 8.55785 96.22979580992957 112.86102170888536 97.6817785401308 59.0663;67.0093;54.7452;52.4905;65.6237;60.1903;87.0256;104.193;73.9175;34.4455;41.6322;31.2175;94.9138;3.54778;33.1119;34.7775 40.5797;44.4373;38.3503;37.1479;42.6891;43.9036;56.6266;59.1667;47.5608;26.6907;30.9494;24.8356;58.8146;1.51564;24.2098;26.6562 108.188;135.846;95.3373;89.1422;135.744;101.057;104.563;434.985;165.416;48.4857;63.3196;42.0237;118.773;8.55785;50.4329;49.7705 10 6 10 257644;83500;25664;296371;63868;24471;25413;25599;25649;140668 ZWINT_10214;SLC22A8_9848;PPARG_32510;PLTP_32412;HSPD1_8849;HSPB1_8847;CPT2_8374;CD74_8252;APOA2_33095;ABCC3_7941 49.93069799999999 47.06135 27.151053101483853 34.77199399999999 34.04865 16.762835778654466 73.38805500000001 76.2309 36.09007007508703 59.0663;52.4905;60.1903;87.0256;34.4455;41.6322;31.2175;94.9138;3.54778;34.7775 40.5797;37.1479;43.9036;56.6266;26.6907;30.9494;24.8356;58.8146;1.51564;26.6562 108.188;89.1422;101.057;104.563;48.4857;63.3196;42.0237;118.773;8.55785;49.7705 6 361604;117267;503568;315994;293502;114628 SYTL2_32351;SLC26A2_33072;SLC13A4_9836;MAPKAPK3_9194;KIF22_8963;ABCG5_7947 66.43343333333333 66.31649999999999 23.365456560287157 42.73566666666667 43.5632 11.476913078814643 169.62686666666667 135.79500000000002 135.97647394736586 67.0093;54.7452;65.6237;104.193;73.9175;33.1119 44.4373;38.3503;42.6891;59.1667;47.5608;24.2098 135.846;95.3373;135.744;434.985;165.416;50.4329 0 Exp 2,5(0.32);Hill,1(0.07);Linear,8(0.5);Poly 2,2(0.13) 1.7103582892305262 27.65411078929901 1.5084086656570435 2.5319817066192627 0.27604124379674905 1.6539189219474792 43.22584974467015 69.01259775532984 30.353741152536905 45.1630013474631 62.3250094281345 156.63020932186546 UP 0.625 0.375 0.0 GO:0090066 4 regulation of anatomical structure size 103 112 4 4 3 4 3 3 93 109 2342 0.38212 0.80456 0.79807 2.68 64159;155423;81633 sptan1;anxa7;acta2 SPTAN1_9932;ANXA7_8051;ACTA2_33040 67.55843333333333 64.7676 47.5519 21.53799031533199 73.42880479637135 22.435311340582956 49.35383333333334 43.3787 34.4152 18.658116469872645 54.82057473460722 19.71596103811397 102.54956666666665 103.57 76.6397 25.415018852311206 102.21606088592935 21.793557033456295 47.5519;64.7676;90.3558 34.4152;43.3787;70.2676 76.6397;127.439;103.57 2 1 2 64159;155423 SPTAN1_9932;ANXA7_8051 56.15975 56.15975 12.173338212873205 38.896950000000004 38.896950000000004 6.338151633165573 102.03935 102.03935 35.92052950952977 47.5519;64.7676 34.4152;43.3787 76.6397;127.439 1 81633 ACTA2_33040 90.3558 90.3558 70.2676 70.2676 103.57 103.57 90.3558 70.2676 103.57 0 Linear,2(0.67);Poly 2,1(0.34) 1.5597273785625003 4.680711388587952 1.5062377452850342 1.600624918937683 0.048643512136940736 1.5738487243652344 43.185902900866836 91.93096376579985 28.24018694308669 70.46747972357997 73.78976543401777 131.30936789931556 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0048869 3 cellular developmental process 541 573 22 22 15 22 15 15 81 558 1893 0.060264 0.9659 0.10623 2.62 360243;25123;64305;78968;24950;25664;363465;65035;259241;25626;24484;58868;155423;65155;81633 top2a;tagln;sult1b1;srebf1;srd5a1;pparg;pir;nr1i3;nr1d2;krt8;igfbp3;fzd1;anxa7;alas1;acta2 TOP2A_10059;TAGLN_9981;SULT1B1_32942;SREBF1_32750;SRD5A1_32503;PPARG_32510;PIR_9487;NR1I3_32602;NR1D2_9358;KRT8_8978;IGFBP3_8881;FZD1_8671;ANXA7_8051;ALAS1_8018;ACTA2_33040 25664(0.0441) 49.84284000000001 50.946 15.4629 24.458225049219834 47.741301968823066 23.861566034510872 32.45988533333333 35.0852 7.69418 16.44268219214245 31.773767062859026 16.998424697008858 92.27350666666666 85.0816 35.0879 49.34479092223654 88.723987318947 48.021278915056804 54.9577;45.9044;15.4629;41.2009;29.2087;60.1903;52.1607;22.095;99.0234;68.9539;50.946;25.231;64.7676;27.1843;90.3558 18.8326;35.0852;7.69418;31.4864;22.9308;43.9036;40.9644;12.9529;42.5557;45.3374;36.3081;13.6792;43.3787;21.5215;70.2676 218.525;67.7714;35.0879;60.0774;39.9852;101.057;74.9097;55.8619;102.838;143.578;85.0816;131.659;127.439;36.6615;103.57 11 4 11 25123;64305;78968;25664;363465;65035;259241;25626;58868;155423;65155 TAGLN_9981;SULT1B1_32942;SREBF1_32750;PPARG_32510;PIR_9487;NR1I3_32602;NR1D2_9358;KRT8_8978;FZD1_8671;ANXA7_8051;ALAS1_8018 47.4704 45.9044 24.936934880654434 30.778107272727276 35.0852 14.259083414532006 85.17643636363636 74.9097 38.31686852338725 45.9044;15.4629;41.2009;60.1903;52.1607;22.095;99.0234;68.9539;25.231;64.7676;27.1843 35.0852;7.69418;31.4864;43.9036;40.9644;12.9529;42.5557;45.3374;13.6792;43.3787;21.5215 67.7714;35.0879;60.0774;101.057;74.9097;55.8619;102.838;143.578;131.659;127.439;36.6615 4 360243;24950;24484;81633 TOP2A_10059;SRD5A1_32503;IGFBP3_8881;ACTA2_33040 56.36704999999999 52.95185 25.325778380996198 37.08477500000001 29.61945 23.346520080213942 111.79044999999999 94.32579999999999 76.00262398494323 54.9577;29.2087;50.946;90.3558 18.8326;22.9308;36.3081;70.2676 218.525;39.9852;85.0816;103.57 0 Exp 2,5(0.34);Exp 4,1(0.07);Linear,5(0.34);Poly 2,3(0.2);Power,1(0.07) 1.8292256721481235 27.865631818771362 1.5124053955078125 2.7270524501800537 0.35939813648378766 1.8061060905456543 37.46527035632625 62.220409643673754 24.138740051839207 40.78103061482746 67.30159701404921 117.24541631928409 UP 0.7333333333333333 0.26666666666666666 0.0 GO:0007049 3 cell cycle 49 56 2 2 2 2 2 2 94 54 2397 0.64598 0.63169 1.0 3.57 291234;303575 mki67;kif18b MKI67_9232;KIF18B_32882 57.88225 57.88225 49.7822 11.455200565900178 61.067592949950026 10.532274236241944 39.81085 39.81085 35.6665 5.860995977220891 41.44061476128239 5.388785344654593 107.02235 107.02235 82.1147 35.2247364368422 116.81727809640964 32.386738400421315 49.7822;65.9823 35.6665;43.9552 82.1147;131.93 0 2 0 2 291234;303575 MKI67_9232;KIF18B_32882 57.88225 57.88225 11.455200565900178 39.81085 39.81085 5.860995977220891 107.02235 107.02235 35.2247364368422 49.7822;65.9823 35.6665;43.9552 82.1147;131.93 0 Linear,2(1) 1.984603388222667 4.008852243423462 1.7232260704040527 2.285626173019409 0.3976769262993287 2.004426121711731 42.00615200000001 73.75834799999998 31.687924000000002 47.933776 58.203356 155.841344 DOWN 0.0 1.0 0.0 GO:0009892 5 negative regulation of metabolic process 589 626 26 25 20 26 19 19 77 607 1844 0.1612 0.89303 0.33324 3.04 361604;78968;84386;299270;309607;24679;25664;24614;65035;259241;24484;63868;24471;299626;58868;25427;65210;25649;155423 sytl2;srebf1;slpi;serpina6;rt1-ce5;prkar2b;pparg;orm1;nr1i3;nr1d2;igfbp3;hspd1;hspb1;gadd45b;fzd1;cyp51;cyp2j4;apoa2;anxa7 SYTL2_32351;SREBF1_32750;SLPI_9890;SERPINA6_32325;RT1-CE5_32445;PRKAR2B_33052;PPARG_32510;ORM1_9400;NR1I3_32602;NR1D2_9358;IGFBP3_8881;HSPD1_8849;HSPB1_8847;GADD45B_8679;FZD1_8671;CYP51_8429;CYP2J4_32580;APOA2_33095;ANXA7_8051 25664(0.0441) 50.740767368421054 52.5718 3.54778 27.087908054599822 46.67084294761314 24.143987529107132 31.676696842105258 36.3081 1.51564 15.000750532748194 29.912103271082362 14.150104565807732 90.86872368421052 89.5095 8.55785 44.84861700539683 82.41775400124669 40.6037519924074 67.0093;41.2009;53.7429;68.3847;54.8206;108.746;60.1903;24.2519;22.095;99.0234;50.946;34.4455;41.6322;52.5718;25.231;75.1522;16.3155;3.54778;64.7676 44.4373;31.4864;37.8192;36.9679;26.5902;59.3814;43.9036;19.7133;12.9529;42.5557;36.3081;26.6907;30.9494;37.1918;13.6792;48.098;8.2378;1.51564;43.3787 135.846;60.0774;92.543;89.5095;147.824;147.467;101.057;31.358;55.8619;102.838;85.0816;48.4857;63.3196;89.36;131.659;171.379;36.8422;8.55785;127.439 14 5 14 78968;299270;24679;25664;24614;65035;259241;63868;24471;299626;58868;65210;25649;155423 SREBF1_32750;SERPINA6_32325;PRKAR2B_33052;PPARG_32510;ORM1_9400;NR1I3_32602;NR1D2_9358;HSPD1_8849;HSPB1_8847;GADD45B_8679;FZD1_8671;CYP2J4_32580;APOA2_33095;ANXA7_8051 47.31454142857143 41.41655 30.580230213809166 29.186031428571425 31.2179 16.281212906659707 78.13086785714286 76.3398 41.276341684560904 41.2009;68.3847;108.746;60.1903;24.2519;22.095;99.0234;34.4455;41.6322;52.5718;25.231;16.3155;3.54778;64.7676 31.4864;36.9679;59.3814;43.9036;19.7133;12.9529;42.5557;26.6907;30.9494;37.1918;13.6792;8.2378;1.51564;43.3787 60.0774;89.5095;147.467;101.057;31.358;55.8619;102.838;48.4857;63.3196;89.36;131.659;36.8422;8.55785;127.439 5 361604;84386;309607;24484;25427 SYTL2_32351;SLPI_9890;RT1-CE5_32445;IGFBP3_8881;CYP51_8429 60.334199999999996 54.8206 10.321257238098454 38.65056 37.8192 8.282074679873414 126.53472 135.846 36.826420587561884 67.0093;53.7429;54.8206;50.946;75.1522 44.4373;37.8192;26.5902;36.3081;48.098 135.846;92.543;147.824;85.0816;171.379 0 Exp 2,5(0.27);Exp 4,1(0.06);Hill,1(0.06);Linear,7(0.37);Poly 2,3(0.16);Power,2(0.11) 1.8246840759878686 35.55677378177643 1.512166976928711 3.5849626064300537 0.5006395107437168 1.7262524366378784 38.56055844990699 62.920976286935115 24.93153678562916 38.42185689858137 70.7023260527997 111.03512131562134 UP 0.7368421052631579 0.2631578947368421 0.0 GO:0003062 7 regulation of heart rate by chemical signal 1 1 1 1 1 1 1 1 95 0 2451 1.0 0.037691 0.037691 100.0 78968 srebf1 SREBF1_32750 41.2009 41.2009 41.2009 41.2009 31.4864 31.4864 31.4864 31.4864 60.0774 60.0774 60.0774 60.0774 0.0 41.2009 0.0 41.2009 41.2009 31.4864 60.0774 1 0 1 78968 SREBF1_32750 41.2009 41.2009 31.4864 31.4864 60.0774 60.0774 41.2009 31.4864 60.0774 0 0 Exp 2,1(1) 1.912555456161499 1.912555456161499 1.912555456161499 1.912555456161499 0.0 1.912555456161499 41.2009 41.2009 31.4864 31.4864 60.0774 60.0774 UP 1.0 0.0 0.0 GO:0055085 4 transmembrane transport 188 198 6 6 6 6 6 6 90 192 2259 0.37123 0.77066 0.69935 3.03 117267;83500;503568;63868;114628;140668 slc26a2;slc22a8;slc13a4;hspd1;abcg5;abcc3 SLC26A2_33072;SLC22A8_9848;SLC13A4_9836;HSPD1_8849;ABCG5_7947;ABCC3_7941 45.865716666666664 43.634 33.1119 13.631878968127111 44.76716935694663 12.135829493148591 32.624 31.9193 24.2098 7.696490996291739 32.09786915690929 7.226757850519567 78.1521 69.78755 48.4857 35.17642647802645 74.33042599685274 29.080134538913516 54.7452;52.4905;65.6237;34.4455;33.1119;34.7775 38.3503;37.1479;42.6891;26.6907;24.2098;26.6562 95.3373;89.1422;135.744;48.4857;50.4329;49.7705 3 3 3 83500;63868;140668 SLC22A8_9848;HSPD1_8849;ABCC3_7941 40.57116666666667 34.7775 10.323780137785441 30.164933333333334 26.6907 6.047451129470446 62.46613333333334 49.7705 23.111081267723762 52.4905;34.4455;34.7775 37.1479;26.6907;26.6562 89.1422;48.4857;49.7705 3 117267;503568;114628 SLC26A2_33072;SLC13A4_9836;ABCG5_7947 51.160266666666665 54.7452 16.549715860501458 35.08306666666667 38.3503 9.663190071779255 93.83806666666665 95.3373 42.6753057545384 54.7452;65.6237;33.1119 38.3503;42.6891;24.2098 95.3373;135.744;50.4329 0 Exp 2,3(0.5);Linear,3(0.5) 1.7852227562679073 10.896743178367615 1.5239086151123047 2.5319817066192627 0.39053430236133385 1.6539189219474792 34.957941748952216 56.77349158438111 26.465524588059026 38.78247541194098 50.00509669040714 106.29910330959284 CONFLICT 0.5 0.5 0.0 GO:0046903 5 secretion 115 123 2 2 2 2 2 2 94 121 2330 0.14697 0.95224 0.32545 1.63 361604;140668 sytl2;abcc3 SYTL2_32351;ABCC3_7941 50.8934 50.8934 34.7775 22.79132434984857 54.25603370551291 22.28968045408225 35.54675 35.54675 26.6562 12.573136386956092 37.401791486392185 12.296397877936753 92.80825 92.80825 49.7705 60.864569744022674 101.78821318911376 59.524922279405985 67.0093;34.7775 44.4373;26.6562 135.846;49.7705 1 1 1 140668 ABCC3_7941 34.7775 34.7775 26.6562 26.6562 49.7705 49.7705 34.7775 26.6562 49.7705 1 361604 SYTL2_32351 67.0093 67.0093 44.4373 44.4373 135.846 135.846 67.0093 44.4373 135.846 0 Linear,2(1) 1.7381981281423566 3.51018226146698 1.512166976928711 1.998015284538269 0.3435466329387262 1.75509113073349 19.306236000000016 82.48056399999999 18.121272 52.972228 8.454260000000005 177.16224 CONFLICT 0.5 0.5 0.0 GO:0043406 9 positive regulation of MAP kinase activity 68 75 3 3 3 3 3 3 93 72 2379 0.68747 0.54353 0.75974 4.0 29455;299626;25599 gdf15;gadd45b;cd74 GDF15_33113;GADD45B_8679;CD74_8252 56.28366666666667 52.5718 21.3654 36.91443147677252 69.3441847140803 29.586989224077577 37.96463333333333 37.1918 17.8875 20.47449223114783 45.529895846698366 15.685904118881853 78.16193333333332 89.36 26.3528 47.216743479546885 98.22475037053424 29.361264991182964 21.3654;52.5718;94.9138 17.8875;37.1918;58.8146 26.3528;89.36;118.773 3 0 3 29455;299626;25599 GDF15_33113;GADD45B_8679;CD74_8252 56.28366666666667 52.5718 36.91443147677252 37.96463333333333 37.1918 20.47449223114783 78.16193333333332 89.36 47.216743479546885 21.3654;52.5718;94.9138 17.8875;37.1918;58.8146 26.3528;89.36;118.773 0 0 Exp 2,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 2.34586307389044 8.225605845451355 1.5528020858764648 5.015069484710693 1.96934870860864 1.6577342748641968 14.511055044477324 98.05627828885599 14.795564275032085 61.13370239163458 24.731158199312475 131.59270846735416 UP 1.0 0.0 0.0 GO:0014070 5 response to organic cyclic compound 433 471 25 24 20 24 19 19 77 452 1999 0.68733 0.41092 0.68969 4.03 286954;78968;24950;83500;24679;25664;24614;291234;24484;63868;58868;25315;65210;114494;25612;25649;155423;65155;140668 ugt2b1;srebf1;srd5a1;slc22a8;prkar2b;pparg;orm1;mki67;igfbp3;hspd1;fzd1;ephx1;cyp2j4;ccna2;asns;apoa2;anxa7;alas1;abcc3 UGT2B10_33303,UGT2B1_33224;SREBF1_32750;SRD5A1_32503;SLC22A8_9848;PRKAR2B_33052;PPARG_32510;ORM1_9400;MKI67_9232;IGFBP3_8881;HSPD1_8849;FZD1_8671;EPHX1_8567;CYP2J4_32580;CCNA2_8221;ASNS_8091;APOA2_33095;ANXA7_8051;ALAS1_8018;ABCC3_7941 25664(0.0441) 39.50836999999999 34.4455 3.54778 23.45658584925186 37.414565404737736 21.383838826048216 27.48579394736842 26.6562 1.51564 14.278805051160672 26.36512053467128 14.023673688499693 67.13447368421053 49.7705 8.55785 39.44897440021014 63.508772876251925 36.35356858988663 12.54415;41.2009;29.2087;52.4905;108.746;60.1903;24.2519;49.7822;50.946;34.4455;25.231;34.0134;16.3155;52.8265;28.1893;3.54778;64.7676;27.1843;34.7775 7.348245;31.4864;22.9308;37.1479;59.3814;43.9036;19.7133;35.6665;36.3081;26.6907;13.6792;26.1579;8.2378;37.3288;23.1774;1.51564;43.3787;21.5215;26.6562 25.495849999999997;60.0774;39.9852;89.1422;147.467;101.057;31.358;82.1147;85.0816;48.4857;131.659;48.3681;36.8422;90.0448;35.9474;8.55785;127.439;36.6615;49.7705 16 4 15 286954;78968;83500;24679;25664;24614;63868;58868;25315;65210;25612;25649;155423;65155;140668 UGT2B10_33303,UGT2B1_33224;SREBF1_32750;SLC22A8_9848;PRKAR2B_33052;PPARG_32510;ORM1_9400;HSPD1_8849;FZD1_8671;EPHX1_8567;CYP2J4_32580;ASNS_8091;APOA2_33095;ANXA7_8051;ALAS1_8018;ABCC3_7941 37.85970866666666 34.0134 25.833543449343658 25.999725666666663 26.1579 15.525097581383566 65.22191333333333 48.4857 43.21759522523565 12.54415;41.2009;52.4905;108.746;60.1903;24.2519;34.4455;25.231;34.0134;16.3155;28.1893;3.54778;64.7676;27.1843;34.7775 7.348245;31.4864;37.1479;59.3814;43.9036;19.7133;26.6907;13.6792;26.1579;8.2378;23.1774;1.51564;43.3787;21.5215;26.6562 25.495849999999997;60.0774;89.1422;147.467;101.057;31.358;48.4857;131.659;48.3681;36.8422;35.9474;8.55785;127.439;36.6615;49.7705 4 24950;291234;24484;114494 SRD5A1_32503;MKI67_9232;IGFBP3_8881;CCNA2_8221 45.690850000000005 50.3641 11.059453209660319 33.058550000000004 35.987300000000005 6.786440734533316 74.306575 83.59815 23.113607015547515 29.2087;49.7822;50.946;52.8265 22.9308;35.6665;36.3081;37.3288 39.9852;82.1147;85.0816;90.0448 0 Exp 2,5(0.25);Exp 4,2(0.1);Hill,1(0.05);Linear,9(0.45);Poly 2,2(0.1);Power,1(0.05) 1.9174889579839296 39.46723008155823 1.5124053955078125 3.5849626064300537 0.5474270347954493 1.788633644580841 28.96100268086026 50.05573731913974 21.06526016973927 33.906327724997574 49.3960514757787 84.87289589264233 UP 0.7894736842105263 0.21052631578947367 0.0 GO:0033043 6 regulation of organelle organization 271 282 9 9 7 9 7 7 89 275 2176 0.1484 0.92147 0.31755 2.48 360243;78968;64159;291234;306575;64515;170465 top2a;srebf1;sptan1;mki67;ckap2;cdc20;acaa2 TOP2A_10059;SREBF1_32750;SPTAN1_9932;MKI67_9232;CKAP2_8324;CDC20_8255;ACAA2_7955 62.524800000000006 54.9577 41.2009 21.12587311536889 62.65311334377175 20.785211040587953 36.953185714285716 35.6665 18.8326 10.501121030859592 37.582946818769265 10.025748435537825 159.24807142857142 98.7727 60.0774 139.82896430174634 149.92810027338703 132.4584657262325 54.9577;41.2009;47.5519;49.7822;64.2131;101.569;78.3988 18.8326;31.4864;34.4152;35.6665;43.1133;51.5499;43.6084 218.525;60.0774;76.6397;82.1147;125.437;453.17;98.7727 2 5 2 78968;64159 SREBF1_32750;SPTAN1_9932 44.376400000000004 44.376400000000004 4.490835167315706 32.9508 32.9508 2.0709743407391157 68.35855000000001 68.35855000000001 11.711314642045908 41.2009;47.5519 31.4864;34.4152 60.0774;76.6397 5 360243;291234;306575;64515;170465 TOP2A_10059;MKI67_9232;CKAP2_8324;CDC20_8255;ACAA2_7955 69.78416 64.2131 20.829228896264986 38.554140000000004 43.1133 12.374357223427808 195.60388000000003 125.437 153.3339055461218 54.9577;49.7822;64.2131;101.569;78.3988 18.8326;35.6665;43.1133;51.5499;43.6084 218.525;82.1147;125.437;453.17;98.7727 0 Exp 2,3(0.43);Linear,3(0.43);Poly 2,1(0.15) 1.8793852283247405 13.402662515640259 1.5062377452850342 2.6341071128845215 0.41167803157256 1.8061060905456543 46.87453418213599 78.17506581786401 29.173846388473187 44.732525040098245 55.66132505324967 262.8348178038932 DOWN 0.2857142857142857 0.7142857142857143 0.0 GO:0043085 5 positive regulation of catalytic activity 340 363 11 11 7 11 7 7 89 356 2095 0.025987 0.98925 0.051717 1.93 25664;63868;29455;299626;64515;25599;25649 pparg;hspd1;gdf15;gadd45b;cdc20;cd74;apoa2 PPARG_32510;HSPD1_8849;GDF15_33113;GADD45B_8679;CDC20_8255;CD74_8252;APOA2_33095 25664(0.0441) 52.65765428571429 52.5718 3.54778 36.41729718826794 57.59447163506393 34.213087088499925 33.93624857142857 37.1918 1.51564 20.001149804478263 37.347059046115994 19.400363377555454 120.82233571428573 89.36 8.55785 151.98690381891655 120.75603050688143 135.21606861948055 60.1903;34.4455;21.3654;52.5718;101.569;94.9138;3.54778 43.9036;26.6907;17.8875;37.1918;51.5499;58.8146;1.51564 101.057;48.4857;26.3528;89.36;453.17;118.773;8.55785 6 1 6 25664;63868;29455;299626;25599;25649 PPARG_32510;HSPD1_8849;GDF15_33113;GADD45B_8679;CD74_8252;APOA2_33095 44.505763333333334 43.50865 32.14429190637844 31.00064 31.94125 20.190732816081738 65.43105833333334 68.92285 44.12704834731658 60.1903;34.4455;21.3654;52.5718;94.9138;3.54778 43.9036;26.6907;17.8875;37.1918;58.8146;1.51564 101.057;48.4857;26.3528;89.36;118.773;8.55785 1 64515 CDC20_8255 101.569 101.569 51.5499 51.5499 453.17 453.17 101.569 51.5499 453.17 0 Exp 2,4(0.58);Hill,1(0.15);Linear,1(0.15);Poly 2,1(0.15) 1.889541982246582 14.660948991775513 1.5239794254302979 5.015069484710693 1.2901495550644213 1.6557694673538208 25.679342986953444 79.63596558447513 19.119189442389235 48.75330770046792 8.228861702092743 233.4158097264787 UP 0.8571428571428571 0.14285714285714285 0.0 GO:0031401 8 positive regulation of protein modification process 319 340 13 13 8 12 8 8 88 332 2119 0.088034 0.95544 0.1682 2.35 78968;24484;29455;299626;58868;64515;25599;81633 srebf1;igfbp3;gdf15;gadd45b;fzd1;cdc20;cd74;acta2 SREBF1_32750;IGFBP3_8881;GDF15_33113;GADD45B_8679;FZD1_8671;CDC20_8255;CD74_8252;ACTA2_33040 59.7692125 51.7589 21.3654 31.75819037739656 63.529000690069005 28.903630127122206 39.648137500000004 36.74995 13.6792 19.560423534264824 42.19926375851871 17.645082693391682 133.505475 96.465 26.3528 133.34652445379993 131.2326484677039 121.55292100750393 41.2009;50.946;21.3654;52.5718;25.231;101.569;94.9138;90.3558 31.4864;36.3081;17.8875;37.1918;13.6792;51.5499;58.8146;70.2676 60.0774;85.0816;26.3528;89.36;131.659;453.17;118.773;103.57 5 3 5 78968;29455;299626;58868;25599 SREBF1_32750;GDF15_33113;GADD45B_8679;FZD1_8671;CD74_8252 47.05658 41.2009 29.54408916419662 31.8119 31.4864 17.894683611341097 85.24444 89.36 43.00296127603307 41.2009;21.3654;52.5718;25.231;94.9138 31.4864;17.8875;37.1918;13.6792;58.8146 60.0774;26.3528;89.36;131.659;118.773 3 24484;64515;81633 IGFBP3_8881;CDC20_8255;ACTA2_33040 80.95693333333334 90.3558 26.588081036685068 52.70853333333334 51.5499 17.009371930301604 213.94053333333332 103.57 207.38492839368377 50.946;101.569;90.3558 36.3081;51.5499;70.2676 85.0816;453.17;103.57 0 Exp 2,3(0.38);Linear,2(0.25);Poly 2,3(0.38) 1.8842103949406694 16.518537521362305 1.5124053955078125 5.015069484710693 1.1993582890423347 1.62917959690094 37.76190936141094 81.77651563858906 26.093455538519592 53.2028194614804 41.10104794483908 225.9099020551609 UP 0.625 0.375 0.0 GO:0044057 5 regulation of system process 160 167 4 4 3 4 3 3 93 164 2287 0.11369 0.95786 0.20799 1.8 78968;25649;114628 srebf1;apoa2;abcg5 SREBF1_32750;APOA2_33095;ABCG5_7947 25.953526666666665 33.1119 3.54778 19.820976086412426 28.540214067380923 18.598581083946627 19.070613333333334 24.2098 1.51564 15.632339666234653 21.108157605954997 14.700865287461232 39.68938333333333 50.4329 8.55785 27.388562774009028 43.26498316552644 25.649116743760434 41.2009;3.54778;33.1119 31.4864;1.51564;24.2098 60.0774;8.55785;50.4329 2 1 2 78968;25649 SREBF1_32750;APOA2_33095 22.37434 22.37434 26.624776484830814 16.50102 16.50102 21.19252763331453 34.317625 34.317625 36.42982316867939 41.2009;3.54778 31.4864;1.51564 60.0774;8.55785 1 114628 ABCG5_7947 33.1119 33.1119 24.2098 24.2098 50.4329 50.4329 33.1119 24.2098 50.4329 0 Exp 2,2(0.67);Hill,1(0.34) 2.0295182843461803 6.17078959941864 1.7262524366378784 2.5319817066192627 0.42182092396033755 1.912555456161499 3.52398074364762 48.38307258968571 1.380955725179419 36.76027094148725 8.696306916362822 70.68245975030385 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0006721 6 terpenoid metabolic process 29 34 6 6 4 6 4 4 92 30 2421 0.992 0.03697 0.03697 11.76 24950;65210;25086;499353 srd5a1;cyp2j4;cyp2e1;cyp2c24 SRD5A1_32503;CYP2J4_32580;CYP2E1_8421;CYP2C24_32875 28.08986 22.7621 7.89174 22.359177900355217 28.99857942192343 23.12370642430554 20.8717675 15.5843 4.16797 19.891395521302464 21.252613876655527 20.83586430992886 43.263000000000005 38.4137 15.8079 26.994756189428088 45.86021972947948 27.078982830666664 0.5 12.10362 2.5 44.0761 29.2087;16.3155;7.89174;58.9435 22.9308;8.2378;4.16797;48.1505 39.9852;36.8422;15.8079;80.4167 3 1 3 65210;25086;499353 CYP2J4_32580;CYP2E1_8421;CYP2C24_32875 27.716913333333334 16.3155 27.369046736642716 20.185423333333333 8.2378 24.30380656989011 44.3556 36.8422 32.953188677728896 16.3155;7.89174;58.9435 8.2378;4.16797;48.1505 36.8422;15.8079;80.4167 1 24950 SRD5A1_32503 29.2087 29.2087 22.9308 22.9308 39.9852 39.9852 29.2087 22.9308 39.9852 0 Exp 2,1(0.25);Exp 4,2(0.5);Linear,1(0.25) 1.988271279685511 8.118619799613953 1.5310101509094238 2.6958487033843994 0.48530246860321535 1.9458804726600647 6.177865657651882 50.001854342348125 1.3781998891235858 40.365335110876416 16.808138934360468 69.71786106563954 UP 0.75 0.25 0.0 GO:0016999 5 antibiotic metabolic process 46 51 4 4 4 4 4 4 92 47 2404 0.9591 0.12353 0.12353 7.84 286954;360268;64305;50549 ugt2b1;sult1e1;sult1b1;cyp4a1 UGT2B10_33303,UGT2B1_33224;SULT1E1_32446;SULT1B1_32942;CYP4A1_33111 27.6219875 19.335449999999998 12.54415 21.5750483988787 31.0127271185094 24.607197510783806 19.80420625 13.27859 7.348245 17.826071811088656 21.75264276111398 20.60371987202705 45.5317125 32.5366 25.495849999999997 30.933265146289127 53.07080792181479 33.58192432519001 1.5 19.335449999999998 12.54415;59.2729;15.4629;23.208 7.348245;45.3114;7.69418;18.863 25.495849999999997;91.5578;35.0879;29.9853 5 0 4 286954;360268;64305;50549 UGT2B10_33303,UGT2B1_33224;SULT1E1_32446;SULT1B1_32942;CYP4A1_33111 27.6219875 19.335449999999998 21.5750483988787 19.80420625 13.27859 17.826071811088656 45.5317125 32.5366 30.933265146289127 12.54415;59.2729;15.4629;23.208 7.348245;45.3114;7.69418;18.863 25.495849999999997;91.5578;35.0879;29.9853 0 0 Exp 2,2(0.4);Exp 4,2(0.4);Poly 2,1(0.2) 1.9411357570819852 9.972585201263428 1.619360327720642 2.9455835819244385 0.5582739775290753 1.729828953742981 6.47844006909887 48.765534930901126 2.334655875133116 37.273756624866884 15.217112656636669 75.84631234336332 UP 1.0 0.0 0.0 GO:0051301 3 cell division 78 79 6 6 6 6 6 6 90 73 2378 0.97264 0.074647 0.12044 7.59 257644;360243;304951;303575;297594;64515 zwint;top2a;nuf2;kif18b;cdca3;cdc20 ZWINT_10214;TOP2A_10059;NUF2_33136;KIF18B_32882;CDCA3_8260;CDC20_8255 54.71663333333343 57.012 5.73955E-13 32.85976682666286 60.00984511149746 27.182596964121192 29.338283333333433 30.846000000000004 5.73955E-13 19.350197257435386 34.347770603045255 16.886666637249842 173.2165000000001 129.708 5.73957E-13 153.91902918840142 173.42679492866566 140.155190084124 2.5 57.012 59.0663;54.9577;5.73955E-13;65.9823;46.7245;101.569 40.5797;18.8326;5.73955E-13;43.9552;21.1123;51.5499 108.188;218.525;5.73957E-13;131.93;127.486;453.17 1 5 1 257644 ZWINT_10214 59.0663 59.0663 40.5797 40.5797 108.188 108.188 59.0663 40.5797 108.188 5 360243;304951;303575;297594;64515 TOP2A_10059;NUF2_33136;KIF18B_32882;CDCA3_8260;CDC20_8255 53.84670000000011 54.9577 36.66100741721352 27.090000000000117 21.1123 20.739499337616422 186.2222000000001 131.93 168.36039525137718 54.9577;5.73955E-13;65.9823;46.7245;101.569 18.8326;5.73955E-13;43.9552;21.1123;51.5499 218.525;5.73957E-13;131.93;127.486;453.17 0 Exp 2,3(0.5);Hill,1(0.17);Linear,2(0.34) 1.7795216761093713 10.777374505996704 1.5293418169021606 2.3038084506988525 0.27892851037848254 1.7646660804748535 28.423343814561928 81.00992285210494 13.854900830379837 44.821665836287025 50.05562614939639 296.3773738506038 DOWN 0.16666666666666666 0.8333333333333334 0.0 GO:0065004 7 protein-DNA complex assembly 28 35 3 3 3 3 3 3 93 32 2419 0.95943 0.14305 0.14305 8.57 313245;316273;102551184 polr1e;mcm3;loc102551184 POLR1E_9523;MCM3_9207;HIST1H4A_32934 62.1056 58.3303 54.0045 10.510223314944314 57.13235511525103 8.239855982819158 40.3516 40.2068 33.259 7.166097283738212 35.92511916640353 6.1799736703398676 127.79233333333333 111.753 105.902 32.97807241688535 118.27583438585413 22.845459270351142 0.5 56.1674 73.982;54.0045;58.3303 47.589;33.259;40.2068 165.722;111.753;105.902 1 2 1 313245 POLR1E_9523 73.982 73.982 47.589 47.589 165.722 165.722 73.982 47.589 165.722 2 316273;102551184 MCM3_9207;HIST1H4A_32934 56.1674 56.1674 3.058802514056686 36.7329 36.7329 4.912836494327889 108.8275 108.8275 4.137281776722447 54.0045;58.3303 33.259;40.2068 111.753;105.902 0 Exp 2,1(0.34);Linear,2(0.67) 1.6094178796005534 4.832300782203674 1.5184675455093384 1.6584177017211914 0.07994770274694567 1.6554155349731445 50.21216269015264 73.99903730984737 32.24239753622162 48.46080246377838 90.47413131833565 165.11053534833104 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0031331 7 positive regulation of cellular catabolic process 107 115 5 5 2 5 2 2 94 113 2338 0.18105 0.93781 0.3207 1.74 24484;64515 igfbp3;cdc20 IGFBP3_8881;CDC20_8255 76.2575 76.2575 50.946 35.79586658400661 76.57802961601307 35.7929963265234 43.929 43.929 36.3081 10.77758013748912 44.025506495098035 10.776715947486421 269.1258 269.1258 85.0816 260.27780371610635 271.45642508169936 260.25693358820837 50.946;101.569 36.3081;51.5499 85.0816;453.17 0 2 0 2 24484;64515 IGFBP3_8881;CDC20_8255 76.2575 76.2575 35.79586658400661 43.929 43.929 10.77758013748912 269.1258 269.1258 260.27780371610635 50.946;101.569 36.3081;51.5499 85.0816;453.17 0 Exp 2,1(0.5);Linear,1(0.5) 1.6303381030754889 3.267345905303955 1.5293418169021606 1.7380040884017944 0.14754650715517953 1.6336729526519775 26.646959999999993 125.86804 28.992036000000006 58.865964 -91.60083199999997 629.852432 DOWN 0.0 1.0 0.0 GO:0051048 6 negative regulation of secretion 62 66 8 8 7 8 7 7 89 59 2392 0.99713 0.010937 0.010937 10.61 78968;309607;25664;24484;25427;25599;25649 srebf1;rt1-ce5;pparg;igfbp3;cyp51;cd74;apoa2 SREBF1_32750;RT1-CE5_32445;PPARG_32510;IGFBP3_8881;CYP51_8429;CD74_8252;APOA2_33095 25664(0.0441) 54.39594 54.8206 3.54778 28.512631101797663 53.792848371629276 28.813558721076454 35.24522 36.3081 1.51564 18.36450176926851 35.26877304600045 18.421795401693295 98.9642642857143 101.057 8.55785 54.62931081640693 90.83663800475865 48.03667587609972 2.5 52.8833 5.5 85.03299999999999 41.2009;54.8206;60.1903;50.946;75.1522;94.9138;3.54778 31.4864;26.5902;43.9036;36.3081;48.098;58.8146;1.51564 60.0774;147.824;101.057;85.0816;171.379;118.773;8.55785 4 3 4 78968;25664;25599;25649 SREBF1_32750;PPARG_32510;CD74_8252;APOA2_33095 49.963195 50.6956 38.106513571987925 33.93006 37.695 24.3267885897776 72.11631249999999 80.5672 48.9864724558113 41.2009;60.1903;94.9138;3.54778 31.4864;43.9036;58.8146;1.51564 60.0774;101.057;118.773;8.55785 3 309607;24484;25427 RT1-CE5_32445;IGFBP3_8881;CYP51_8429 60.30626666666666 54.8206 13.002093435033238 36.99876666666667 36.3081 10.770521368222306 134.76153333333332 147.824 44.60696513161749 54.8206;50.946;75.1522 26.5902;36.3081;48.098 147.824;85.0816;171.379 0 Exp 2,3(0.43);Hill,1(0.15);Linear,2(0.29);Poly 2,1(0.15) 1.7156546748248775 12.039689898490906 1.5239794254302979 1.912555456161499 0.1313198758528882 1.7262524366378784 33.27348728654499 75.51839271345501 21.640606702734743 48.84983329726525 58.49430448549646 139.4342240859321 CONFLICT 0.5714285714285714 0.42857142857142855 0.0 GO:0043604 6 amide biosynthetic process 50 60 4 4 4 4 4 4 92 56 2395 0.92686 0.18807 0.28509 6.67 298490;362094;364975;25612 ppcs;mrps2;gcdh;asns PPCS_9540;MRPS2_9250;GCDH_8693;ASNS_8091 30.629075 22.0457 15.1091 22.59887836396237 38.42523598313761 25.891144571555802 21.7209025 16.80005 7.94061 17.104248906573623 27.1355911030814 19.406848600348027 52.276325 33.6146 30.6311 39.38368642042668 66.94062032520326 45.28151266844733 2.0 28.1893 15.1091;63.3158;15.9021;28.1893 7.94061;45.3429;10.4227;23.1774 30.6311;111.245;31.2818;35.9474 4 0 4 298490;362094;364975;25612 PPCS_9540;MRPS2_9250;GCDH_8693;ASNS_8091 30.629075 22.0457 22.59887836396237 21.7209025 16.80005 17.104248906573623 52.276325 33.6146 39.38368642042668 15.1091;63.3158;15.9021;28.1893 7.94061;45.3429;10.4227;23.1774 30.6311;111.245;31.2818;35.9474 0 0 Exp 2,2(0.5);Hill,1(0.25);Poly 2,1(0.25) 1.9564955667438686 8.237046360969543 1.5277283191680908 3.2609751224517822 0.8194276112873534 1.7241714596748352 8.482174203316877 52.77597579668313 4.958738571557852 38.48306642844215 13.680312307981865 90.87233769201814 UP 1.0 0.0 0.0 GO:0007610 2 behavior 142 151 5 5 4 5 4 4 92 147 2304 0.3161 0.83276 0.65759 2.65 24950;24679;259241;29455 srd5a1;prkar2b;nr1d2;gdf15 SRD5A1_32503;PRKAR2B_33052;NR1D2_9358;GDF15_33113 64.585875 64.11605 21.3654 45.664040332072744 71.03973336108567 43.92016026220913 35.68885 32.74325 17.8875 19.045090846462244 38.307374440096574 18.18192285899999 79.16075000000001 71.41159999999999 26.3528 56.42032511317766 86.9214069269836 53.942946550578 29.2087;108.746;99.0234;21.3654 22.9308;59.3814;42.5557;17.8875 39.9852;147.467;102.838;26.3528 3 1 3 24679;259241;29455 PRKAR2B_33052;NR1D2_9358;GDF15_33113 76.37826666666666 99.0234 47.88991398878613 39.94153333333333 42.5557 20.870106248491723 92.21926666666667 102.838 61.25137127945247 108.746;99.0234;21.3654 59.3814;42.5557;17.8875 147.467;102.838;26.3528 1 24950 SRD5A1_32503 29.2087 29.2087 22.9308 22.9308 39.9852 39.9852 29.2087 22.9308 39.9852 0 Exp 2,1(0.25);Linear,1(0.25);Power,2(0.5) 2.5645138382909263 11.314205169677734 1.6208000183105469 5.015069484710693 1.5296433394070368 2.339167833328247 19.83511547456871 109.3366345254313 17.024660970467004 54.353039029533 23.868831389085884 134.45266861091415 UP 0.75 0.25 0.0 GO:0010941 5 regulation of cell death 479 511 18 18 13 18 13 13 83 498 1953 0.062665 0.96551 0.11876 2.54 29142;360243;309607;25664;24484;63868;24471;299626;58868;25599;25612;50559;170465 vnn1;top2a;rt1-ce5;pparg;igfbp3;hspd1;hspb1;gadd45b;fzd1;cd74;asns;acot1;acaa2 VNN1_10157;TOP2A_10059;RT1-CE5_32445;PPARG_32510;IGFBP3_8881;HSPD1_8849;HSPB1_8847;GADD45B_8679;FZD1_8671;CD74_8252;ASNS_8091;ACOT1_7968;ACAA2_7955 25664(0.0441) 48.118707692307694 50.946 20.7328 21.710816542162465 54.05764220450307 21.67867983781355 30.870507692307687 26.6907 13.6792 12.756259993918132 34.39011064122902 13.150544787728487 92.23484615384616 89.36 26.7838 54.109523374689076 99.18108565305725 47.08684226075162 20.7328;54.9577;54.8206;60.1903;50.946;34.4455;41.6322;52.5718;25.231;94.9138;28.1893;28.5134;78.3988 16.8296;18.8326;26.5902;43.9036;36.3081;26.6907;30.9494;37.1918;13.6792;58.8146;23.1774;24.741;43.6084 26.7838;218.525;147.824;101.057;85.0816;48.4857;63.3196;89.36;131.659;118.773;35.9474;33.4642;98.7727 9 4 9 29142;25664;63868;24471;299626;58868;25599;25612;50559 VNN1_10157;PPARG_32510;HSPD1_8849;HSPB1_8847;GADD45B_8679;FZD1_8671;CD74_8252;ASNS_8091;ACOT1_7968 42.935566666666666 34.4455 23.446655819274106 30.66414444444444 26.6907 14.129884952566956 72.09441111111111 63.3196 39.290715629409334 20.7328;60.1903;34.4455;41.6322;52.5718;25.231;94.9138;28.1893;28.5134 16.8296;43.9036;26.6907;30.9494;37.1918;13.6792;58.8146;23.1774;24.741 26.7838;101.057;48.4857;63.3196;89.36;131.659;118.773;35.9474;33.4642 4 360243;309607;24484;170465 TOP2A_10059;RT1-CE5_32445;IGFBP3_8881;ACAA2_7955 59.780775 54.88915 12.550557659422944 31.334825 31.449150000000003 10.865713718658041 137.550825 123.29835 60.329975114994326 54.9577;54.8206;50.946;78.3988 18.8326;26.5902;36.3081;43.6084 218.525;147.824;85.0816;98.7727 0 Exp 2,6(0.47);Linear,4(0.31);Poly 2,3(0.24) 2.4868029819622794 75.62745082378387 1.5124053955078125 50.888092041015625 13.571151433205928 1.7380040884017944 36.316573380083156 59.92084200453222 23.936125769015796 37.804889615599585 62.82057418492436 121.64911812276793 UP 0.6923076923076923 0.3076923076923077 0.0 GO:0040008 4 regulation of growth 171 186 7 7 4 7 4 4 92 182 2269 0.15666 0.93018 0.31535 2.15 25664;24484;25685;29455 pparg;igfbp3;igfbp1;gdf15 PPARG_32510;IGFBP3_8881;IGFBP1_32306;GDF15_33113 25664(0.0441) 57.8347 55.56815 21.3654 31.959399698680222 58.22035544474728 19.310307080666746 38.8568 40.105850000000004 17.8875 16.460688866306093 40.96039771432112 10.139732135878944 142.4751 93.0693 26.3528 146.8450915946915 115.37234394202181 94.05621615521032 60.1903;50.946;98.8371;21.3654 43.9036;36.3081;57.328;17.8875 101.057;85.0816;357.409;26.3528 3 1 3 25664;25685;29455 PPARG_32510;IGFBP1_32306;GDF15_33113 60.13093333333334 60.1903 38.73588411955164 39.70636666666667 43.9036 20.052452114475507 161.60626666666667 101.057 173.6352848934033 60.1903;98.8371;21.3654 43.9036;57.328;17.8875 101.057;357.409;26.3528 1 24484 IGFBP3_8881 50.946 50.946 36.3081 36.3081 85.0816 85.0816 50.946 36.3081 85.0816 0 Exp 2,2(0.5);Linear,2(0.5) 2.279314101153248 10.308988213539124 1.5239794254302979 5.015069484710693 1.638499787217224 1.8849696516990662 26.514488295293404 89.1549117047066 22.725324911020028 54.988275088979975 -1.433089762797664 286.38328976279763 UP 0.75 0.25 0.0 GO:0097327 5 response to antineoplastic agent 75 80 3 3 3 3 3 3 93 77 2374 0.64386 0.58813 1.0 3.75 24950;83500;25612 srd5a1;slc22a8;asns SRD5A1_32503;SLC22A8_9848;ASNS_8091 36.6295 29.2087 28.1893 13.745482342937262 42.15712776225079 14.416323622492536 27.752033333333333 23.1774 22.9308 8.137993346233046 31.004533705980993 8.567871784230316 55.02493333333334 39.9852 35.9474 29.61531480186109 66.96267753555681 30.9731012092258 29.2087;52.4905;28.1893 22.9308;37.1479;23.1774 39.9852;89.1422;35.9474 2 1 2 83500;25612 SLC22A8_9848;ASNS_8091 40.3399 40.3399 17.18354331097053 30.16265 30.16265 9.87863528656666 62.5448 62.5448 37.61440380386217 52.4905;28.1893 37.1479;23.1774 89.1422;35.9474 1 24950 SRD5A1_32503 29.2087 29.2087 22.9308 22.9308 39.9852 39.9852 29.2087 22.9308 39.9852 0 Exp 2,1(0.34);Linear,2(0.67) 2.19061103446483 6.86432671546936 1.6520683765411377 3.2609751224517822 0.8557066598287456 1.9512832164764404 21.07502245556129 52.1839775444387 18.54302694107571 36.96103972559096 21.512049786272897 88.53781688039376 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0043401 6 steroid hormone mediated signaling pathway 34 37 3 3 3 3 3 3 93 34 2417 0.95165 0.16117 0.16117 8.11 25664;65035;259241 pparg;nr1i3;nr1d2 PPARG_32510;NR1I3_32602;NR1D2_9358 25664(0.0441) 60.43623333333333 60.1903 22.095 38.46478966591828 53.69717176028774 33.86848547616296 33.1374 42.5557 12.9529 17.49327695973513 32.466590780704536 17.987699422276414 86.58563333333332 101.057 55.8619 26.62243100664055 85.05856552417221 26.910152555764544 0.5 41.14265 60.1903;22.095;99.0234 43.9036;12.9529;42.5557 101.057;55.8619;102.838 3 0 3 25664;65035;259241 PPARG_32510;NR1I3_32602;NR1D2_9358 60.43623333333333 60.1903 38.46478966591828 33.1374 42.5557 17.49327695973513 86.58563333333332 101.057 26.62243100664055 60.1903;22.095;99.0234 43.9036;12.9529;42.5557 101.057;55.8619;102.838 0 0 Exp 2,1(0.34);Poly 2,1(0.34);Power,1(0.34) 2.0472290204531816 6.315587997436523 1.5239794254302979 2.7270524501800537 0.6025652457962786 2.064556121826172 16.909226264170435 103.96324040249624 13.341893603044959 52.93290639695504 56.45951662532772 116.71175004133895 UP 1.0 0.0 0.0 GO:0044281 3 small molecule metabolic process 449 498 54 53 48 53 46 46 50 452 1999 1.0 1.4305E-10 1.4305E-10 9.24 29142;286954;360268;64305;78968;24950;293820;24679;298490;25664;296371;680308;291234;24552;25685;364975;65030;25315;171142;291075;29740;64526;117543;114027;25427;50549;65210;25086;24303;499353;171521;29277;24894;311849;25413;25599;25612;25649;502970;24763;50681;681337;314304;192272;50559;170465 vnn1;ugt2b1;sult1e1;sult1b1;srebf1;srd5a1;psat1;prkar2b;ppcs;pparg;pltp;mthfd2;mki67;me1;igfbp1;gcdh;ephx2;ephx1;ehhadh;eci2;eci1;ech1;decr1;dao;cyp51;cyp4a1;cyp2j4;cyp2e1;cyp2d3;cyp2c24;cyp2c13;cyp2c11;cyp2a1;crat;cpt2;cd74;asns;apoa2;angptl3;acsm3;acox1;acot4;acot3;acot2;acot1;acaa2 VNN1_10157;UGT2B10_33303,UGT2B1_33224;SULT1E1_32446;SULT1B1_32942;SREBF1_32750;SRD5A1_32503;PSAT1_9583;PRKAR2B_33052;PPCS_9540;PPARG_32510;PLTP_32412;MTHFD2_9261;MKI67_9232;ME1_9215;IGFBP1_32306;GCDH_8693;EPHX2_33282;EPHX1_8567;EHHADH_8534;ECI2_8521;ECI1_8520;ECH1_8516;DECR1_8458;DAO_8437;CYP51_8429;CYP4A1_33111;CYP2J4_32580;CYP2E1_8421;CYP2D3_8420;CYP2C24_32875;CYP2C13_8419;CYP2C11_32593;CYP2A1_32717;CRAT_8375;CPT2_8374;CD74_8252;ASNS_8091;APOA2_33095;ANGPTL3_8045;ACSM3_7976;ACOX1_7973;ACOT4_7971;ACOT3_7970;ACOT2_7969;ACOT1_7968;ACAA2_7955 25664(0.0441) 36.53058260869565 27.26045 3.54778 29.696708604028938 38.3112252032669 29.990838859370633 24.71920010869565 21.9248 1.51564 18.54160400698663 25.66800589112178 18.926420920367963 59.261093478260875 35.6214 8.55785 59.3156999553562 57.95805367983873 44.30532040780523 23.5 28.35135 20.7328;12.54415;59.2729;15.4629;41.2009;29.2087;26.3316;108.746;15.1091;60.1903;87.0256;57.4184;49.7822;49.3339;98.8371;15.9021;6.44145;34.0134;7.29984;8.72912;11.7653;9.87438;21.6199;6.1336;75.1522;23.208;16.3155;7.89174;12.8059;58.9435;104.635;54.426;9.37187;8.98517;31.2175;94.9138;28.1893;3.54778;58.0729;52.2057;23.8014;12.3157;30.8838;13.6362;28.5134;78.3988 16.8296;7.348245;45.3114;7.69418;31.4864;22.9308;20.9188;59.3814;7.94061;43.9036;56.6266;46.387;35.6665;35.4173;57.328;10.4227;2.66377;26.1579;5.26587;5.10151;8.40998;6.59127;17.4928;2.43617;48.098;18.863;8.2378;4.16797;8.8664;48.1505;49.2461;43.9518;4.95906;1.97988;24.8356;58.8146;23.1774;1.51564;40.0757;42.2655;19.0993;6.70485;24.6874;11.3249;24.741;43.6084 26.7838;25.495849999999997;91.5578;35.0879;60.0774;39.9852;35.2954;147.467;30.6311;101.057;104.563;79.7903;82.1147;80.9924;357.409;31.2818;17.3473;48.3681;11.8779;17.7951;18.8402;19.44;28.0829;16.2027;171.379;29.9853;36.8422;15.8079;22.6004;80.4167;108.327;74.8861;19.1079;31.3726;42.0237;118.773;35.9474;8.55785;105.112;71.1126;31.3543;24.3993;41.2585;16.9658;33.4642;98.7727 43 4 42 29142;286954;360268;64305;78968;293820;24679;298490;25664;296371;680308;24552;25685;364975;65030;25315;171142;291075;29740;64526;117543;114027;50549;65210;25086;24303;499353;171521;29277;24894;311849;25413;25599;25612;25649;502970;24763;50681;681337;314304;192272;50559 VNN1_10157;UGT2B10_33303,UGT2B1_33224;SULT1E1_32446;SULT1B1_32942;SREBF1_32750;PSAT1_9583;PRKAR2B_33052;PPCS_9540;PPARG_32510;PLTP_32412;MTHFD2_9261;ME1_9215;IGFBP1_32306;GCDH_8693;EPHX2_33282;EPHX1_8567;EHHADH_8534;ECI2_8521;ECI1_8520;ECH1_8516;DECR1_8458;DAO_8437;CYP4A1_33111;CYP2J4_32580;CYP2E1_8421;CYP2D3_8420;CYP2C24_32875;CYP2C13_8419;CYP2C11_32593;CYP2A1_32717;CRAT_8375;CPT2_8374;CD74_8252;ASNS_8091;APOA2_33095;ANGPTL3_8045;ACSM3_7976;ACOX1_7973;ACOT4_7971;ACOT3_7970;ACOT2_7969;ACOT1_7968 34.47297380952381 23.5047 29.645730426538407 23.49475011904762 18.98115 18.728624881770582 55.565683333333354 34.27605 59.00121081492027 20.7328;12.54415;59.2729;15.4629;41.2009;26.3316;108.746;15.1091;60.1903;87.0256;57.4184;49.3339;98.8371;15.9021;6.44145;34.0134;7.29984;8.72912;11.7653;9.87438;21.6199;6.1336;23.208;16.3155;7.89174;12.8059;58.9435;104.635;54.426;9.37187;8.98517;31.2175;94.9138;28.1893;3.54778;58.0729;52.2057;23.8014;12.3157;30.8838;13.6362;28.5134 16.8296;7.348245;45.3114;7.69418;31.4864;20.9188;59.3814;7.94061;43.9036;56.6266;46.387;35.4173;57.328;10.4227;2.66377;26.1579;5.26587;5.10151;8.40998;6.59127;17.4928;2.43617;18.863;8.2378;4.16797;8.8664;48.1505;49.2461;43.9518;4.95906;1.97988;24.8356;58.8146;23.1774;1.51564;40.0757;42.2655;19.0993;6.70485;24.6874;11.3249;24.741 26.7838;25.495849999999997;91.5578;35.0879;60.0774;35.2954;147.467;30.6311;101.057;104.563;79.7903;80.9924;357.409;31.2818;17.3473;48.3681;11.8779;17.7951;18.8402;19.44;28.0829;16.2027;29.9853;36.8422;15.8079;22.6004;80.4167;108.327;74.8861;19.1079;31.3726;42.0237;118.773;35.9474;8.55785;105.112;71.1126;31.3543;24.3993;41.2585;16.9658;33.4642 4 24950;291234;25427;170465 SRD5A1_32503;MKI67_9232;CYP51_8429;ACAA2_7955 58.135475 62.4672 23.142362202301197 37.575925 39.63745 11.033742293943918 98.06289999999998 90.4437 54.78174469589911 29.2087;49.7822;75.1522;78.3988 22.9308;35.6665;48.098;43.6084 39.9852;82.1147;171.379;98.7727 0 Exp 2,12(0.26);Exp 4,6(0.13);Hill,8(0.18);Linear,12(0.26);Poly 2,7(0.15);Power,2(0.05) 2.251346173940419 152.78285706043243 1.5084086656570435 50.888092041015625 7.143109623029067 1.912555456161499 27.94864262513327 45.11252259225803 19.360931793218064 30.077468424173247 42.11967272731613 76.40251422920561 UP 0.9130434782608695 0.08695652173913043 0.0 GO:0045935 7 positive regulation of nucleobase-containing compound metabolic process 358 387 13 13 11 13 11 11 85 376 2075 0.18704 0.88504 0.38362 2.84 360243;78968;25664;54133;65035;259241;24484;58868;306575;25599;114494 top2a;srebf1;pparg;pdlim1;nr1i3;nr1d2;igfbp3;fzd1;ckap2;cd74;ccna2 TOP2A_10059;SREBF1_32750;PPARG_32510;PDLIM1_9452;NR1I3_32602;NR1D2_9358;IGFBP3_8881;FZD1_8671;CKAP2_8324;CD74_8252;CCNA2_8221 25664(0.0441) 57.51930909090909 54.9577 22.095 24.29084151051398 57.61277602466916 23.31720684444177 35.11064545454545 37.3288 12.9529 14.630682582666047 36.72922443787743 14.703189064741881 110.29715454545455 102.838 55.8619 43.96395172400598 107.13364467000726 41.11785318002414 54.9577;41.2009;60.1903;67.1147;22.095;99.0234;50.946;25.231;64.2131;94.9138;52.8265 18.8326;31.4864;43.9036;47.2419;12.9529;42.5557;36.3081;13.6792;43.1133;58.8146;37.3288 218.525;60.0774;101.057;123.914;55.8619;102.838;85.0816;131.659;125.437;118.773;90.0448 7 4 7 78968;25664;54133;65035;259241;58868;25599 SREBF1_32750;PPARG_32510;PDLIM1_9452;NR1I3_32602;NR1D2_9358;FZD1_8671;CD74_8252 58.538442857142854 60.1903 31.02842742286806 35.804899999999996 42.5557 17.329278943260547 99.16861428571428 102.838 30.201865687207093 41.2009;60.1903;67.1147;22.095;99.0234;25.231;94.9138 31.4864;43.9036;47.2419;12.9529;42.5557;13.6792;58.8146 60.0774;101.057;123.914;55.8619;102.838;131.659;118.773 4 360243;24484;306575;114494 TOP2A_10059;IGFBP3_8881;CKAP2_8324;CCNA2_8221 55.735825000000006 53.8921 5.884336989769191 33.895700000000005 36.81845 10.479614826573203 129.7721 107.7409 61.83680000873266 54.9577;50.946;64.2131;52.8265 18.8326;36.3081;43.1133;37.3288 218.525;85.0816;125.437;90.0448 0 Exp 2,4(0.37);Linear,3(0.28);Poly 2,3(0.28);Power,1(0.1) 1.9182805351382173 21.538066148757935 1.5124053955078125 2.7270524501800537 0.4300433539066097 1.8061060905456543 43.16433909277866 71.87427908903952 26.464464570468863 43.75682633862206 84.31611935883095 136.27818973207812 UP 0.6363636363636364 0.36363636363636365 0.0 GO:0030335 7 positive regulation of cell migration 186 194 4 4 4 4 4 4 92 190 2261 0.13122 0.94362 0.24053 2.06 24471;25599;502970;81633 hspb1;cd74;angptl3;acta2 HSPB1_8847;CD74_8252;ANGPTL3_8045;ACTA2_33040 71.243675 74.21435 41.6322 25.66357279171851 70.92754618803183 24.64335531140396 50.026825 49.44515 30.9494 17.794072003970868 48.97456188376339 16.376804369016455 97.69364999999999 104.341 63.3196 23.912881576464244 100.32415575154165 22.397225330077124 41.6322;94.9138;58.0729;90.3558 30.9494;58.8146;40.0757;70.2676 63.3196;118.773;105.112;103.57 3 1 3 24471;25599;502970 HSPB1_8847;CD74_8252;ANGPTL3_8045 64.87296666666667 58.0729 27.28393125345636 43.2799 40.0757 14.206249187945446 95.73486666666668 105.112 28.89148429993398 41.6322;94.9138;58.0729 30.9494;58.8146;40.0757 63.3196;118.773;105.112 1 81633 ACTA2_33040 90.3558 90.3558 70.2676 70.2676 103.57 103.57 90.3558 70.2676 103.57 0 Linear,2(0.5);Poly 2,2(0.5) 1.6567967761860942 6.642799973487854 1.5375925302505493 1.8468482494354248 0.1334471565404698 1.62917959690094 46.09337366411588 96.3939763358841 32.58863443610855 67.46501556389146 74.2590260550651 121.12827394493488 UP 0.75 0.25 0.0 GO:0033540 8 fatty acid beta-oxidation using acyl-CoA oxidase 3 3 2 2 2 2 2 2 94 1 2450 0.99995 0.0041153 0.0041153 66.67 311849;50681 crat;acox1 CRAT_8375;ACOX1_7973 16.393285 16.393285 8.98517 10.476656704619565 11.992576198194278 8.427802785416219 10.53959 10.53959 1.97988 12.105257971980604 5.454788922005874 9.737908736615863 31.36345 31.36345 31.3543 0.012940054077687333 31.368885456325458 0.010409449044379702 0.0 8.98517 0.0 8.98517 8.98517;23.8014 1.97988;19.0993 31.3726;31.3543 2 0 2 311849;50681 CRAT_8375;ACOX1_7973 16.393285 16.393285 10.476656704619565 10.53959 10.53959 12.105257971980604 31.36345 31.36345 0.012940054077687333 8.98517;23.8014 1.97988;19.0993 31.3726;31.3543 0 0 Hill,1(0.5);Linear,1(0.5) 1.6466771462635632 3.296768546104431 1.5733836889266968 1.7233848571777344 0.10606684325621295 1.6483842730522156 1.8733795999999998 30.913190399999998 -6.237441599999999 27.316621599999998 31.345516 31.381384 UP 1.0 0.0 0.0 GO:0007568 3 aging 181 193 7 7 5 7 5 5 91 188 2263 0.25142 0.8658 0.55256 2.59 360243;78968;24484;25685;24471 top2a;srebf1;igfbp3;igfbp1;hspb1 TOP2A_10059;SREBF1_32750;IGFBP3_8881;IGFBP1_32306;HSPB1_8847 57.51478000000001 50.946 41.2009 23.851733097974222 49.11109997271273 15.45910837101131 34.980900000000005 31.4864 18.8326 14.056906253155418 31.565854925349864 9.606045532634896 156.88252 85.0816 60.0774 129.70282176164093 112.09919999999997 95.54185302558136 54.9577;41.2009;50.946;98.8371;41.6322 18.8326;31.4864;36.3081;57.328;30.9494 218.525;60.0774;85.0816;357.409;63.3196 3 2 3 78968;25685;24471 SREBF1_32750;IGFBP1_32306;HSPB1_8847 60.55673333333334 41.6322 33.1524713863587 39.92126666666667 31.4864 15.077064245181594 160.26866666666666 63.3196 170.73623293048647 41.2009;98.8371;41.6322 31.4864;57.328;30.9494 60.0774;357.409;63.3196 2 360243;24484 TOP2A_10059;IGFBP3_8881 52.95185 52.95185 2.8367002740860277 27.57035 27.57035 12.357044554625517 151.8033 151.8033 94.35873304458893 54.9577;50.946 18.8326;36.3081 218.525;85.0816 0 Exp 2,2(0.4);Linear,3(0.6) 1.8644460942625716 9.33544909954071 1.7380040884017944 2.031935214996338 0.11184027769814633 1.8468482494354248 36.60781413740519 78.4217458625948 22.65947840932423 47.30232159067578 43.192984077633284 270.5720559223667 UP 0.6 0.4 0.0 GO:0034641 4 cellular nitrogen compound metabolic process 478 543 29 28 26 29 25 25 71 518 1933 0.8974 0.15282 0.2535 4.6 29142;360243;360268;64305;78968;24950;298490;313245;680308;362094;291234;316273;293502;63868;364975;311849;362485;25612;65155;24763;681337;314304;192272;50559;170465 vnn1;top2a;sult1e1;sult1b1;srebf1;srd5a1;ppcs;polr1e;mthfd2;mrps2;mki67;mcm3;kif22;hspd1;gcdh;crat;ccne2;asns;alas1;acsm3;acot4;acot3;acot2;acot1;acaa2 VNN1_10157;TOP2A_10059;SULT1E1_32446;SULT1B1_32942;SREBF1_32750;SRD5A1_32503;PPCS_9540;POLR1E_9523;MTHFD2_9261;MRPS2_9250;MKI67_9232;MCM3_9207;KIF22_8963;HSPD1_8849;GCDH_8693;CRAT_8375;CCNE2_8227;ASNS_8091;ALAS1_8018;ACSM3_7976;ACOT4_7971;ACOT3_7970;ACOT2_7969;ACOT1_7968;ACAA2_7955 40.6765868 34.4455 8.98517 22.685600913419492 41.436000222592895 22.939289328042555 27.728888799999996 24.741 1.97988 15.215638094986183 27.78642448160008 15.66135602598598 74.954892 48.4857 16.9658 56.43536038474993 75.7992219296106 52.372858487287765 20.7328;54.9577;59.2729;15.4629;41.2009;29.2087;15.1091;73.982;57.4184;63.3158;49.7822;54.0045;73.9175;34.4455;15.9021;8.98517;77.8893;28.1893;27.1843;52.2057;12.3157;30.8838;13.6362;28.5134;78.3988 16.8296;18.8326;45.3114;7.69418;31.4864;22.9308;7.94061;47.589;46.387;45.3429;35.6665;33.259;47.5608;26.6907;10.4227;1.97988;49.2672;23.1774;21.5215;42.2655;6.70485;24.6874;11.3249;24.741;43.6084 26.7838;218.525;91.5578;35.0879;60.0774;39.9852;30.6311;165.722;79.7903;111.245;82.1147;111.753;165.416;48.4857;31.2818;31.3726;185.461;35.9474;36.6615;71.1126;24.3993;41.2585;16.9658;33.4642;98.7727 18 7 18 29142;360268;64305;78968;298490;313245;680308;362094;63868;364975;311849;25612;65155;24763;681337;314304;192272;50559 VNN1_10157;SULT1E1_32446;SULT1B1_32942;SREBF1_32750;PPCS_9540;POLR1E_9523;MTHFD2_9261;MRPS2_9250;HSPD1_8849;GCDH_8693;CRAT_8375;ASNS_8091;ALAS1_8018;ACSM3_7976;ACOT4_7971;ACOT3_7970;ACOT2_7969;ACOT1_7968 33.26422055555555 28.35135 20.07864072097409 24.560940000000002 23.9324 15.474102447365551 53.991372222222225 36.30445 37.82749849384867 20.7328;59.2729;15.4629;41.2009;15.1091;73.982;57.4184;63.3158;34.4455;15.9021;8.98517;28.1893;27.1843;52.2057;12.3157;30.8838;13.6362;28.5134 16.8296;45.3114;7.69418;31.4864;7.94061;47.589;46.387;45.3429;26.6907;10.4227;1.97988;23.1774;21.5215;42.2655;6.70485;24.6874;11.3249;24.741 26.7838;91.5578;35.0879;60.0774;30.6311;165.722;79.7903;111.245;48.4857;31.2818;31.3726;35.9474;36.6615;71.1126;24.3993;41.2585;16.9658;33.4642 7 360243;24950;291234;316273;293502;362485;170465 TOP2A_10059;SRD5A1_32503;MKI67_9232;MCM3_9207;KIF22_8963;CCNE2_8227;ACAA2_7955 59.73695714285714 54.9577 18.09987920510862 35.87504285714286 35.6665 11.836363867880072 128.8610857142857 111.753 63.06289819321738 54.9577;29.2087;49.7822;54.0045;73.9175;77.8893;78.3988 18.8326;22.9308;35.6665;33.259;47.5608;49.2672;43.6084 218.525;39.9852;82.1147;111.753;165.416;185.461;98.7727 0 Exp 2,11(0.44);Exp 4,1(0.04);Hill,3(0.12);Linear,8(0.32);Poly 2,2(0.08) 2.367786100486686 103.8588616847992 1.5184675455093384 50.888092041015625 9.773241551049004 1.9018945693969727 31.783831241939556 49.56934235806044 21.764358666765425 33.69341893323458 52.83223072917802 97.07755327082195 UP 0.72 0.28 0.0 GO:0009416 5 response to light stimulus 83 88 5 5 2 5 2 2 94 86 2365 0.34644 0.85353 0.77225 2.27 25664;25612 pparg;asns PPARG_32510;ASNS_8091 25664(0.0441) 44.1898 44.1898 28.1893 22.628124104750704 51.68478554465669 19.992058019893125 33.540499999999994 33.540499999999994 23.1774 14.655636568228635 38.394803596627085 12.948326393922361 68.5022 68.5022 35.9474 46.03943968034364 83.75158316985029 40.67606952445351 60.1903;28.1893 43.9036;23.1774 101.057;35.9474 2 0 2 25664;25612 PPARG_32510;ASNS_8091 44.1898 44.1898 22.628124104750704 33.540499999999994 33.540499999999994 14.655636568228635 68.5022 68.5022 46.03943968034364 60.1903;28.1893 43.9036;23.1774 101.057;35.9474 0 0 Exp 2,2(1) 2.229273198478949 4.78495454788208 1.5239794254302979 3.2609751224517822 1.2282414362557454 2.39247727394104 12.828819999999997 75.55078 13.228824 53.852175999999986 4.694792000000007 132.309608 UP 1.0 0.0 0.0 GO:0009636 4 response to toxic substance 240 257 16 16 12 15 11 11 85 246 2205 0.74287 0.37451 0.60518 4.28 286954;78968;24950;83500;63868;24471;65030;25315;25086;25612;65155 ugt2b1;srebf1;srd5a1;slc22a8;hspd1;hspb1;ephx2;ephx1;cyp2e1;asns;alas1 UGT2B10_33303,UGT2B1_33224;SREBF1_32750;SRD5A1_32503;SLC22A8_9848;HSPD1_8849;HSPB1_8847;EPHX2_33282;EPHX1_8567;CYP2E1_8421;ASNS_8091;ALAS1_8018 28.658376363636364 29.2087 6.44145 14.638925090779225 30.538345104957425 15.921320603660522 21.29472590909091 23.1774 2.66377 11.586148291893387 22.466160493037325 12.398631451159751 43.69437727272727 39.9852 15.8079 21.656646451070902 47.526629552001275 24.17455851997194 12.54415;41.2009;29.2087;52.4905;34.4455;41.6322;6.44145;34.0134;7.89174;28.1893;27.1843 7.348245;31.4864;22.9308;37.1479;26.6907;30.9494;2.66377;26.1579;4.16797;23.1774;21.5215 25.495849999999997;60.0774;39.9852;89.1422;48.4857;63.3196;17.3473;48.3681;15.8079;35.9474;36.6615 11 1 10 286954;78968;83500;63868;24471;65030;25315;25086;25612;65155 UGT2B10_33303,UGT2B1_33224;SREBF1_32750;SLC22A8_9848;HSPD1_8849;HSPB1_8847;EPHX2_33282;EPHX1_8567;CYP2E1_8421;ASNS_8091;ALAS1_8018 28.603344 31.101349999999996 15.429582468676639 21.1311185 24.667650000000002 12.199471346211887 44.065295 42.514799999999994 22.791249683991182 12.54415;41.2009;52.4905;34.4455;41.6322;6.44145;34.0134;7.89174;28.1893;27.1843 7.348245;31.4864;37.1479;26.6907;30.9494;2.66377;26.1579;4.16797;23.1774;21.5215 25.495849999999997;60.0774;89.1422;48.4857;63.3196;17.3473;48.3681;15.8079;35.9474;36.6615 1 24950 SRD5A1_32503 29.2087 29.2087 22.9308 22.9308 39.9852 39.9852 29.2087 22.9308 39.9852 0 Exp 2,3(0.25);Exp 4,3(0.25);Linear,5(0.42);Poly 2,1(0.09) 1.9078425022712813 23.38906168937683 1.5310101509094238 3.2609751224517822 0.4693911616756113 1.8430557250976562 20.00732446854012 37.30942825873261 14.447749815157286 28.141702003024534 30.8961170753323 56.49263747012225 UP 0.9090909090909091 0.09090909090909091 0.0 GO:0071103 7 DNA conformation change 30 32 2 2 2 2 2 2 94 30 2421 0.88269 0.34138 0.34138 6.25 360243;316273 top2a;mcm3 TOP2A_10059;MCM3_9207 54.4811 54.4811 54.0045 0.6740141838270891 54.31422963692654 0.6313506821530168 26.0458 26.0458 18.8326 10.201005268109608 28.571333577258656 9.555305792086301 165.139 165.139 111.753 75.49920524085006 146.44713847452857 70.720284342084 0.5 54.4811 54.9577;54.0045 18.8326;33.259 218.525;111.753 0 2 0 2 360243;316273 TOP2A_10059;MCM3_9207 54.4811 54.4811 0.6740141838270891 26.0458 26.0458 10.201005268109608 165.139 165.139 75.49920524085006 54.9577;54.0045 18.8326;33.259 218.525;111.753 0 Exp 2,2(1) 1.7306872368360988 3.4645237922668457 1.6584177017211914 1.8061060905456543 0.10443146124029323 1.7322618961334229 53.546963999999996 55.415236 11.907928 40.183672 60.50244000000002 269.77556 DOWN 0.0 1.0 0.0 GO:0015031 5 protein transport 172 184 5 5 4 5 4 4 92 180 2271 0.16361 0.9264 0.31465 2.17 25664;63868;24471;25599 pparg;hspd1;hspb1;cd74 PPARG_32510;HSPD1_8849;HSPB1_8847;CD74_8252 25664(0.0441) 57.79545 50.911249999999995 34.4455 27.01837664016844 61.32329785278275 27.07213548048908 40.089574999999996 37.4265 26.6907 14.471189748917217 42.14419512028725 14.348627231662867 82.90882500000001 82.1883 48.4857 32.57956708903856 88.0079356086176 31.838507037914997 60.1903;34.4455;41.6322;94.9138 43.9036;26.6907;30.9494;58.8146 101.057;48.4857;63.3196;118.773 4 0 4 25664;63868;24471;25599 PPARG_32510;HSPD1_8849;HSPB1_8847;CD74_8252 57.79545 50.911249999999995 27.01837664016844 40.089574999999996 37.4265 14.471189748917217 82.90882500000001 82.1883 32.57956708903856 60.1903;34.4455;41.6322;94.9138 43.9036;26.6907;30.9494;58.8146 101.057;48.4857;63.3196;118.773 0 0 Exp 2,2(0.5);Linear,1(0.25);Poly 2,1(0.25) 1.6671753318313476 6.68433141708374 1.5239794254302979 1.8468482494354248 0.1328477540959988 1.6567518711090088 31.317440892634917 84.27345910736507 25.907809046061136 54.271340953938875 50.980849252742175 114.83680074725781 UP 1.0 0.0 0.0 GO:0043648 7 dicarboxylic acid metabolic process 32 33 2 2 2 2 2 2 94 31 2420 0.87431 0.3553 0.3553 6.06 24552;681337 me1;acot4 ME1_9215;ACOT4_7971 30.8248 30.8248 12.3157 26.17582024731986 40.41444307730549 22.38863678118374 21.061075 21.061075 6.70485 20.302768099479685 28.499095956582977 17.36531257997145 52.69585 52.69585 24.3993 40.0173647783684 67.3564123622504 34.22755185884803 0.5 30.8248 49.3339;12.3157 35.4173;6.70485 80.9924;24.3993 2 0 2 24552;681337 ME1_9215;ACOT4_7971 30.8248 30.8248 26.17582024731986 21.061075 21.061075 20.302768099479685 52.69585 52.69585 40.0173647783684 49.3339;12.3157 35.4173;6.70485 80.9924;24.3993 0 0 Hill,1(0.5);Linear,1(0.5) 2.2769837659963863 4.670638084411621 1.8166091442108154 2.8540289402008057 0.7335665726816868 2.3353190422058105 -5.453035999999994 67.10263599999999 -7.077125999999996 49.199276 -2.7653879999999944 108.15708799999999 UP 1.0 0.0 0.0 GO:0045893 8 positive regulation of transcription, DNA-templated 299 321 11 11 9 11 9 9 87 312 2139 0.2111 0.87324 0.43213 2.8 360243;78968;25664;65035;259241;58868;306575;25599;114494 top2a;srebf1;pparg;nr1i3;nr1d2;fzd1;ckap2;cd74;ccna2 TOP2A_10059;SREBF1_32750;PPARG_32510;NR1I3_32602;NR1D2_9358;FZD1_8671;CKAP2_8324;CD74_8252;CCNA2_8221 25664(0.0441) 57.18352222222222 54.9577 22.095 26.84249224270064 56.813392254138606 25.758373347634315 33.62967777777778 37.3288 12.9529 15.701226491804524 35.25523831544613 15.851650250311529 111.5859 102.838 55.8619 48.078191595982474 106.59326262275533 45.075426211610356 54.9577;41.2009;60.1903;22.095;99.0234;25.231;64.2131;94.9138;52.8265 18.8326;31.4864;43.9036;12.9529;42.5557;13.6792;43.1133;58.8146;37.3288 218.525;60.0774;101.057;55.8619;102.838;131.659;125.437;118.773;90.0448 6 3 6 78968;25664;65035;259241;58868;25599 SREBF1_32750;PPARG_32510;NR1I3_32602;NR1D2_9358;FZD1_8671;CD74_8252 57.109066666666656 50.6956 33.73653499004703 33.89873333333333 37.02105 18.161594946443074 95.04438333333333 101.94749999999999 30.849720731599295 41.2009;60.1903;22.095;99.0234;25.231;94.9138 31.4864;43.9036;12.9529;42.5557;13.6792;58.8146 60.0774;101.057;55.8619;102.838;131.659;118.773 3 360243;306575;114494 TOP2A_10059;CKAP2_8324;CCNA2_8221 57.332433333333334 54.9577 6.0533613549278815 33.091566666666665 37.3288 12.68281151256825 144.66893333333334 125.437 66.36407833167979 54.9577;64.2131;52.8265 18.8326;43.1133;37.3288 218.525;125.437;90.0448 0 Exp 2,3(0.34);Linear,2(0.23);Poly 2,3(0.34);Power,1(0.12) 1.9740421496664413 18.16409432888031 1.5124053955078125 2.7270524501800537 0.4561548630778814 1.912555456161499 39.64642729032447 74.72061715411998 23.371543136465483 43.887812419090075 80.1748148239581 142.99698517604187 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0015937 7 coenzyme A biosynthetic process 3 3 1 1 1 1 1 1 95 2 2449 0.99588 0.10891 0.10891 33.33 298490 ppcs PPCS_9540 15.1091 15.1091 15.1091 15.1091 7.94061 7.94061 7.94061 7.9406099999999995 30.6311 30.6311 30.6311 30.6311 0.0 15.1091 0.0 15.1091 15.1091 7.94061 30.6311 1 0 1 298490 PPCS_9540 15.1091 15.1091 7.94061 7.94061 30.6311 30.6311 15.1091 7.94061 30.6311 0 0 Hill,1(1) 1.9018945693969727 1.9018945693969727 1.9018945693969727 1.9018945693969727 0.0 1.9018945693969727 15.1091 15.1091 7.94061 7.94061 30.6311 30.6311 UP 1.0 0.0 0.0 GO:0032103 6 positive regulation of response to external stimulus 125 131 4 4 4 4 4 4 92 127 2324 0.444 0.73875 0.81633 3.05 309607;63868;24471;25599 rt1-ce5;hspd1;hspb1;cd74 RT1-CE5_32445;HSPD1_8849;HSPB1_8847;CD74_8252 56.453025 48.2264 34.4455 26.993110449937046 60.13802011320308 28.520568955952406 35.761224999999996 28.820050000000002 26.5902 15.502622165809035 37.81002319484296 16.63111155685568 94.600575 91.0463 48.4857 46.62660253663317 98.02978663181479 45.25443346463834 54.8206;34.4455;41.6322;94.9138 26.5902;26.6907;30.9494;58.8146 147.824;48.4857;63.3196;118.773 3 1 3 63868;24471;25599 HSPD1_8849;HSPB1_8847;CD74_8252 56.99716666666666 41.6322 33.03279395878185 38.81823333333333 30.9494 17.447783278208533 76.85943333333334 63.3196 37.04823140641577 34.4455;41.6322;94.9138 26.6907;30.9494;58.8146 48.4857;63.3196;118.773 1 309607 RT1-CE5_32445 54.8206 54.8206 26.5902 26.5902 147.824 147.824 54.8206 26.5902 147.824 0 Exp 2,2(0.5);Linear,1(0.25);Poly 2,1(0.25) 1.7493834172319054 7.007892727851868 1.6557694673538208 1.8475407361984253 0.10995538817511306 1.7522912621498108 29.999776759061703 82.90627324093829 20.568655277507162 50.953794722492844 48.906504514099495 140.2946454859005 UP 0.75 0.25 0.0 GO:0034613 5 cellular protein localization 184 195 3 3 2 3 2 2 94 193 2258 0.017698 0.99619 0.030591 1.03 361604;63868 sytl2;hspd1 SYTL2_32351;HSPD1_8849 50.7274 50.7274 34.4455 23.026083801202486 52.6113753844915 22.87141903602094 35.564 35.564 26.6907 12.548741203005187 36.59072776391014 12.464452092957492 92.16585 92.16585 48.4857 61.77306053649112 97.22007139866334 61.35813475124217 67.0093;34.4455 44.4373;26.6907 135.846;48.4857 1 1 1 63868 HSPD1_8849 34.4455 34.4455 26.6907 26.6907 48.4857 48.4857 34.4455 26.6907 48.4857 1 361604 SYTL2_32351 67.0093 67.0093 44.4373 44.4373 135.846 135.846 67.0093 44.4373 135.846 0 Exp 2,1(0.5);Linear,1(0.5) 1.5823400108507935 3.1679364442825317 1.512166976928711 1.6557694673538208 0.10154229477487145 1.5839682221412659 18.814876000000012 82.639924 18.172332 52.955668 6.5527560000000165 177.778944 CONFLICT 0.5 0.5 0.0 GO:0032526 5 response to retinoic acid 42 45 4 4 3 4 3 3 93 42 2409 0.91293 0.23933 0.23933 6.67 78968;25664;24614 srebf1;pparg;orm1 SREBF1_32750;PPARG_32510;ORM1_9400 25664(0.0441) 41.881033333333335 41.2009 24.2519 17.978851038187425 42.37134941139165 17.73180078142488 31.701099999999997 31.4864 19.7133 12.096579086254103 32.03790310357129 11.924550989226343 64.16413333333334 60.0774 31.358 35.02875521986662 65.03798732411114 34.6186957858149 1.5 50.6956 41.2009;60.1903;24.2519 31.4864;43.9036;19.7133 60.0774;101.057;31.358 3 0 3 78968;25664;24614 SREBF1_32750;PPARG_32510;ORM1_9400 41.881033333333335 41.2009 17.978851038187425 31.701099999999997 31.4864 12.096579086254103 64.16413333333334 60.0774 35.02875521986662 41.2009;60.1903;24.2519 31.4864;43.9036;19.7133 60.0774;101.057;31.358 0 0 Exp 2,3(1) 2.186213592802232 7.021497488021851 1.5239794254302979 3.5849626064300537 1.0951094831333894 1.912555456161499 21.53604813956265 62.22601852710402 18.012532144224096 45.389667855775905 24.525365272421027 103.80290139424565 UP 1.0 0.0 0.0 GO:0051005 8 negative regulation of lipoprotein lipase activity 3 3 1 1 1 1 1 1 95 2 2449 0.99588 0.10891 0.10891 33.33 502970 angptl3 ANGPTL3_8045 58.0729 58.0729 58.0729 58.0729 40.0757 40.0757 40.0757 40.0757 105.112 105.112 105.112 105.112 0.0 58.0729 0.0 58.0729 58.0729 40.0757 105.112 1 0 1 502970 ANGPTL3_8045 58.0729 58.0729 40.0757 40.0757 105.112 105.112 58.0729 40.0757 105.112 0 0 Linear,1(1) 1.5375925302505493 1.5375925302505493 1.5375925302505493 1.5375925302505493 0.0 1.5375925302505493 58.0729 58.0729 40.0757 40.0757 105.112 105.112 UP 1.0 0.0 0.0 GO:0006928 3 movement of cell or subcellular component 248 268 6 6 5 6 5 5 91 263 2188 0.050491 0.97992 0.090129 1.87 296371;54133;293502;303575;24471 pltp;pdlim1;kif22;kif18b;hspb1 PLTP_32412;PDLIM1_9452;KIF22_8963;KIF18B_32882;HSPB1_8847 67.13446 67.1147 41.6322 16.532998898959594 67.83734167466609 15.287807787847534 45.26678 47.2419 30.9494 9.285967227058253 45.71262010641508 8.60931824893415 117.82852 123.914 63.3196 37.57542228042154 119.91060969254819 34.57008821022878 87.0256;67.1147;73.9175;65.9823;41.6322 56.6266;47.2419;47.5608;43.9552;30.9494 104.563;123.914;165.416;131.93;63.3196 3 2 3 296371;54133;24471 PLTP_32412;PDLIM1_9452;HSPB1_8847 65.2575 67.1147 22.753616960167037 44.9393 47.2419 12.992541130587187 97.26553333333334 104.563 30.949314897963912 87.0256;67.1147;41.6322 56.6266;47.2419;30.9494 104.563;123.914;63.3196 2 293502;303575 KIF22_8963;KIF18B_32882 69.9499 69.9499 5.611033730071356 45.757999999999996 45.757999999999996 2.5495442102462573 148.673 148.673 23.67817767481272 73.9175;65.9823 47.5608;43.9552 165.416;131.93 0 Exp 2,1(0.2);Linear,3(0.6);Poly 2,1(0.2) 1.7382693000880678 8.735226273536682 1.5084086656570435 2.020775556564331 0.19668623951175018 1.7232260704040527 52.642647511278874 81.62627248872113 37.1272708490373 53.40628915096269 84.89221018710516 150.76482981289485 UP 0.6 0.4 0.0 GO:0015833 6 peptide transport 179 191 6 6 5 6 5 5 91 186 2265 0.26065 0.85967 0.55118 2.62 83500;25664;63868;24471;25599 slc22a8;pparg;hspd1;hspb1;cd74 SLC22A8_9848;PPARG_32510;HSPD1_8849;HSPB1_8847;CD74_8252 25664(0.0441) 56.73446 52.4905 34.4455 23.518567262973313 59.149769631835404 23.154057010228268 39.501239999999996 37.1479 26.6907 12.601277313153634 40.914733218733076 12.30073859010845 84.1555 89.1422 48.4857 28.35210991372598 88.28704939631835 26.772744425930526 52.4905;60.1903;34.4455;41.6322;94.9138 37.1479;43.9036;26.6907;30.9494;58.8146 89.1422;101.057;48.4857;63.3196;118.773 5 0 5 83500;25664;63868;24471;25599 SLC22A8_9848;PPARG_32510;HSPD1_8849;HSPB1_8847;CD74_8252 56.73446 52.4905 23.518567262973313 39.501239999999996 37.1479 12.601277313153634 84.1555 89.1422 28.35210991372598 52.4905;60.1903;34.4455;41.6322;94.9138 37.1479;43.9036;26.6907;30.9494;58.8146 89.1422;101.057;48.4857;63.3196;118.773 0 0 Exp 2,2(0.4);Linear,2(0.4);Poly 2,1(0.2) 1.6641429296305221 8.336399793624878 1.5239794254302979 1.8468482494354248 0.1153633581295665 1.6557694673538208 36.119526867703485 77.34939313229653 28.455733431189348 50.54674656881066 59.30377993152629 109.00722006847371 UP 1.0 0.0 0.0 GO:0002933 6 lipid hydroxylation 3 3 2 2 2 2 2 2 94 1 2450 0.99995 0.0041153 0.0041153 66.67 50549;25086 cyp4a1;cyp2e1 CYP4A1_33111;CYP2E1_8421 15.549869999999999 15.549869999999999 7.89174 10.830231308416268 11.265009083704804 8.976293447175829 11.515485 11.515485 4.16797 10.390955362739751 7.404418740300478 8.612213523082808 22.8966 22.8966 15.8079 10.024935679594162 18.930345368994548 8.308849726890951 0.0 7.89174 0.0 7.89174 23.208;7.89174 18.863;4.16797 29.9853;15.8079 2 0 2 50549;25086 CYP4A1_33111;CYP2E1_8421 15.549869999999999 15.549869999999999 10.830231308416268 11.515485 11.515485 10.390955362739751 22.8966 22.8966 10.024935679594162 23.208;7.89174 18.863;4.16797 29.9853;15.8079 0 0 Exp 2,1(0.5);Exp 4,1(0.5) 1.7683676186014454 3.573533535003662 1.5310101509094238 2.0425233840942383 0.36169447585163805 1.786766767501831 0.5399352000000022 30.559804799999995 -2.885644399999997 25.916614399999997 9.002748000000002 36.790451999999995 UP 1.0 0.0 0.0 GO:0007019 6 microtubule depolymerization 5 5 1 1 1 1 1 1 95 4 2447 0.98695 0.1749 0.1749 20.0 303575 kif18b KIF18B_32882 65.9823 65.9823 65.9823 65.9823 43.9552 43.9552 43.9552 43.9552 131.93 131.93 131.93 131.93 0.0 65.9823 0.0 65.9823 65.9823 43.9552 131.93 0 1 0 1 303575 KIF18B_32882 65.9823 65.9823 43.9552 43.9552 131.93 131.93 65.9823 43.9552 131.93 0 Linear,1(1) 1.7232260704040527 1.7232260704040527 1.7232260704040527 1.7232260704040527 0.0 1.7232260704040527 65.9823 65.9823 43.9552 43.9552 131.93 131.93 DOWN 0.0 1.0 0.0 GO:0034605 5 cellular response to heat 21 23 3 3 2 3 2 2 94 21 2430 0.94677 0.21415 0.21415 8.7 291234;63868 mki67;hspd1 MKI67_9232;HSPD1_8849 42.11385 42.11385 34.4455 10.844684571023762 40.85840857263962 10.698360486071412 31.1786 31.1786 26.6907 6.3468490465742144 30.44385320546784 6.261212910918271 65.3002 65.3002 48.4857 23.77929394452239 62.5473757444103 23.458447044416104 0.5 42.11385 49.7822;34.4455 35.6665;26.6907 82.1147;48.4857 1 1 1 63868 HSPD1_8849 34.4455 34.4455 26.6907 26.6907 48.4857 48.4857 34.4455 26.6907 48.4857 1 291234 MKI67_9232 49.7822 49.7822 35.6665 35.6665 82.1147 82.1147 49.7822 35.6665 82.1147 0 Exp 2,1(0.5);Linear,1(0.5) 1.945371437816002 3.94139564037323 1.6557694673538208 2.285626173019409 0.4453759477519569 1.970697820186615 27.083884 57.143816 22.382316000000003 39.974883999999996 32.34378000000001 98.25662 CONFLICT 0.5 0.5 0.0 GO:0031323 5 regulation of cellular metabolic process 979 1054 36 35 25 35 24 24 72 1030 1421 4.8258E-4 0.99979 9.6087E-4 2.28 360243;361604;78968;84386;299270;24679;25664;363465;54133;65035;259241;24484;63868;24471;29455;299626;58868;306575;64515;25599;362485;114494;25649;81633 top2a;sytl2;srebf1;slpi;serpina6;prkar2b;pparg;pir;pdlim1;nr1i3;nr1d2;igfbp3;hspd1;hspb1;gdf15;gadd45b;fzd1;ckap2;cdc20;cd74;ccne2;ccna2;apoa2;acta2 TOP2A_10059;SYTL2_32351;SREBF1_32750;SLPI_9890;SERPINA6_32325;PRKAR2B_33052;PPARG_32510;PIR_9487;PDLIM1_9452;NR1I3_32602;NR1D2_9358;IGFBP3_8881;HSPD1_8849;HSPB1_8847;GDF15_33113;GADD45B_8679;FZD1_8671;CKAP2_8324;CDC20_8255;CD74_8252;CCNE2_8227;CCNA2_8221;APOA2_33095;ACTA2_33040 25664(0.0441) 58.58886583333334 54.350300000000004 3.54778 27.355246071780602 58.085576897501966 24.755110998201875 37.12946 37.574 1.51564 16.135748203171094 37.65367209029996 15.147788862305656 113.82586874999998 96.80000000000001 8.55785 86.01908138486515 109.13491654984023 77.56473830327698 54.9577;67.0093;41.2009;53.7429;68.3847;108.746;60.1903;52.1607;67.1147;22.095;99.0234;50.946;34.4455;41.6322;21.3654;52.5718;25.231;64.2131;101.569;94.9138;77.8893;52.8265;3.54778;90.3558 18.8326;44.4373;31.4864;37.8192;36.9679;59.3814;43.9036;40.9644;47.2419;12.9529;42.5557;36.3081;26.6907;30.9494;17.8875;37.1918;13.6792;43.1133;51.5499;58.8146;49.2672;37.3288;1.51564;70.2676 218.525;135.846;60.0774;92.543;89.5095;147.467;101.057;74.9097;123.914;55.8619;102.838;85.0816;48.4857;63.3196;26.3528;89.36;131.659;125.437;453.17;118.773;185.461;90.0448;8.55785;103.57 15 9 15 78968;299270;24679;25664;363465;54133;65035;259241;63868;24471;29455;299626;58868;25599;25649 SREBF1_32750;SERPINA6_32325;PRKAR2B_33052;PPARG_32510;PIR_9487;PDLIM1_9452;NR1I3_32602;NR1D2_9358;HSPD1_8849;HSPB1_8847;GDF15_33113;GADD45B_8679;FZD1_8671;CD74_8252;APOA2_33095 52.841545333333336 52.1607 30.7709084477154 33.47886933333333 36.9679 16.71151468157188 82.80949666666667 89.36 39.58327987116197 41.2009;68.3847;108.746;60.1903;52.1607;67.1147;22.095;99.0234;34.4455;41.6322;21.3654;52.5718;25.231;94.9138;3.54778 31.4864;36.9679;59.3814;43.9036;40.9644;47.2419;12.9529;42.5557;26.6907;30.9494;17.8875;37.1918;13.6792;58.8146;1.51564 60.0774;89.5095;147.467;101.057;74.9097;123.914;55.8619;102.838;48.4857;63.3196;26.3528;89.36;131.659;118.773;8.55785 9 360243;361604;84386;24484;306575;64515;362485;114494;81633 TOP2A_10059;SYTL2_32351;SLPI_9890;IGFBP3_8881;CKAP2_8324;CDC20_8255;CCNE2_8227;CCNA2_8221;ACTA2_33040 68.16773333333333 64.2131 18.145134351045773 43.21377777777778 43.1133 13.898812457344858 165.51982222222225 125.437 117.13623276409585 54.9577;67.0093;53.7429;50.946;64.2131;101.569;77.8893;52.8265;90.3558 18.8326;44.4373;37.8192;36.3081;43.1133;51.5499;49.2672;37.3288;70.2676 218.525;135.846;92.543;85.0816;125.437;453.17;185.461;90.0448;103.57 0 Exp 2,8(0.34);Hill,1(0.05);Linear,8(0.34);Poly 2,5(0.21);Power,2(0.09) 1.8620974477083327 46.6283894777298 1.512166976928711 5.015069484710693 0.7327175117382837 1.7201437950134277 47.644488038191035 69.53324362847562 30.67381621308606 43.58510378691396 79.4110686858098 148.24066881419023 UP 0.625 0.375 0.0 GO:0009615 5 response to virus 66 68 2 2 2 2 2 2 94 66 2385 0.52318 0.73542 1.0 2.94 24471;81633 hspb1;acta2 HSPB1_8847;ACTA2_33040 65.994 65.994 41.6322 34.45278796382086 64.95873363471972 34.42166535172049 50.6085 50.6085 30.9494 27.80216584404893 49.77307712477397 27.777051010845216 83.4448 83.4448 63.3196 28.461330785470977 82.58956998191684 28.435620501623163 41.6322;90.3558 30.9494;70.2676 63.3196;103.57 1 1 1 24471 HSPB1_8847 41.6322 41.6322 30.9494 30.9494 63.3196 63.3196 41.6322 30.9494 63.3196 1 81633 ACTA2_33040 90.3558 90.3558 70.2676 70.2676 103.57 103.57 90.3558 70.2676 103.57 0 Linear,1(0.5);Poly 2,1(0.5) 1.7193345600966612 3.447473168373108 1.600624918937683 1.8468482494354248 0.1741061866812896 1.723736584186554 18.244872000000008 113.74312799999998 12.076664000000008 89.140336 43.99940800000002 122.89019199999998 CONFLICT 0.5 0.5 0.0 GO:0051384 7 response to glucocorticoid 119 133 8 8 6 8 6 6 90 127 2324 0.76727 0.38618 0.63653 4.51 286954;24950;24614;63868;25315;25649 ugt2b1;srd5a1;orm1;hspd1;ephx1;apoa2 UGT2B10_33303,UGT2B1_33224;SRD5A1_32503;ORM1_9400;HSPD1_8849;EPHX1_8567;APOA2_33095 23.001904999999997 26.7303 3.54778 12.49098314374614 22.385237403211974 12.445772555379815 17.392764166666666 21.32205 1.51564 10.510084504664281 16.961630797669397 10.474272031548043 33.70845 35.6716 8.55785 15.350531851177026 32.70720210434474 15.349841694807179 12.54415;29.2087;24.2519;34.4455;34.0134;3.54778 7.348245;22.9308;19.7133;26.6907;26.1579;1.51564 25.495849999999997;39.9852;31.358;48.4857;48.3681;8.55785 6 1 5 286954;24614;63868;25315;25649 UGT2B10_33303,UGT2B1_33224;ORM1_9400;HSPD1_8849;EPHX1_8567;APOA2_33095 21.760545999999998 24.2519 13.545240257008365 16.285156999999998 19.7133 11.352373897189748 32.4531 31.358 16.81455494426629 12.54415;24.2519;34.4455;34.0134;3.54778 7.348245;19.7133;26.6907;26.1579;1.51564 25.495849999999997;31.358;48.4857;48.3681;8.55785 1 24950 SRD5A1_32503 29.2087 29.2087 22.9308 22.9308 39.9852 39.9852 29.2087 22.9308 39.9852 0 Exp 2,2(0.29);Exp 4,1(0.15);Hill,1(0.15);Linear,2(0.29);Poly 2,1(0.15) 1.9650312063142221 14.283613085746765 1.635288953781128 3.5849626064300537 0.6955127435044334 1.729828953742981 13.007036871291318 32.99677312870868 8.982945064613206 25.802583268720127 21.42546636352997 45.99143363647003 UP 0.8333333333333334 0.16666666666666666 0.0 GO:0033197 6 response to vitamin E 15 17 2 2 2 2 2 2 94 15 2436 0.97597 0.13262 0.13262 11.76 25664;24614 pparg;orm1 PPARG_32510;ORM1_9400 25664(0.0441) 42.2211 42.2211 24.2519 25.412286344994627 43.006860993211426 25.38797858442247 31.80845 31.80845 19.7133 17.10512516893693 32.33734928750535 17.088763505074112 66.2075 66.2075 31.358 49.2846355419212 67.73140633600391 49.23749302572355 0.0 24.2519 0.5 42.2211 60.1903;24.2519 43.9036;19.7133 101.057;31.358 2 0 2 25664;24614 PPARG_32510;ORM1_9400 42.2211 42.2211 25.412286344994627 31.80845 31.80845 17.10512516893693 66.2075 66.2075 49.2846355419212 60.1903;24.2519 43.9036;19.7133 101.057;31.358 0 0 Exp 2,2(1) 2.337393688092867 5.108942031860352 1.5239794254302979 3.5849626064300537 1.457335183196349 2.554471015930176 7.001468000000003 77.440732 8.101956000000008 55.51494399999999 -2.0975199999999887 134.51252 UP 1.0 0.0 0.0 GO:1903902 6 positive regulation of viral life cycle 11 12 2 2 2 2 2 2 94 10 2441 0.99109 0.072579 0.072579 16.67 360243;25599 top2a;cd74 TOP2A_10059;CD74_8252 74.93575 74.93575 54.9577 28.25322925976782 80.36081713068853 27.19158430213375 38.8236 38.8236 18.8326 28.271543325400536 44.25218372111365 27.209210197389407 168.649 168.649 118.773 70.53531563692052 155.10510316271 67.88487658471279 0.0 54.9577 0.5 74.93575 54.9577;94.9138 18.8326;58.8146 218.525;118.773 1 1 1 25599 CD74_8252 94.9138 94.9138 58.8146 58.8146 118.773 118.773 94.9138 58.8146 118.773 1 360243 TOP2A_10059 54.9577 54.9577 18.8326 18.8326 218.525 218.525 54.9577 18.8326 218.525 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.730330595677748 3.463840365409851 1.6577342748641968 1.8061060905456543 0.10491471700531914 1.7319201827049255 35.77877200000001 114.092728 -0.35875999999999664 78.00595999999999 70.89204 266.40596 CONFLICT 0.5 0.5 0.0 GO:0009725 4 response to hormone 388 419 26 26 19 25 19 19 77 400 2051 0.85072 0.22 0.39869 4.53 286954;360243;78968;24950;25664;24614;24552;24484;63868;24471;58868;25315;114494;25612;25649;502970;65155;192272;140668 ugt2b1;top2a;srebf1;srd5a1;pparg;orm1;me1;igfbp3;hspd1;hspb1;fzd1;ephx1;ccna2;asns;apoa2;angptl3;alas1;acot2;abcc3 UGT2B10_33303,UGT2B1_33224;TOP2A_10059;SREBF1_32750;SRD5A1_32503;PPARG_32510;ORM1_9400;ME1_9215;IGFBP3_8881;HSPD1_8849;HSPB1_8847;FZD1_8671;EPHX1_8567;CCNA2_8221;ASNS_8091;APOA2_33095;ANGPTL3_8045;ALAS1_8018;ACOT2_7969;ABCC3_7941 25664(0.0441) 35.58895421052632 34.4455 3.54778 16.196365862355698 36.92178329168795 16.988565811766218 25.00093078947368 26.1579 1.51564 11.356310671283202 26.162539748718036 11.979990870582716 67.23498421052632 49.7705 8.55785 49.0919499856931 67.40482632865776 46.147227097624324 12.54415;54.9577;41.2009;29.2087;60.1903;24.2519;49.3339;50.946;34.4455;41.6322;25.231;34.0134;52.8265;28.1893;3.54778;58.0729;27.1843;13.6362;34.7775 7.348245;18.8326;31.4864;22.9308;43.9036;19.7133;35.4173;36.3081;26.6907;30.9494;13.6792;26.1579;37.3288;23.1774;1.51564;40.0757;21.5215;11.3249;26.6562 25.495849999999997;218.525;60.0774;39.9852;101.057;31.358;80.9924;85.0816;48.4857;63.3196;131.659;48.3681;90.0448;35.9474;8.55785;105.112;36.6615;16.9658;49.7705 16 4 15 286954;78968;25664;24614;24552;63868;24471;58868;25315;25612;25649;502970;65155;192272;140668 UGT2B10_33303,UGT2B1_33224;SREBF1_32750;PPARG_32510;ORM1_9400;ME1_9215;HSPD1_8849;HSPB1_8847;FZD1_8671;EPHX1_8567;ASNS_8091;APOA2_33095;ANGPTL3_8045;ALAS1_8018;ACOT2_7969;ABCC3_7941 32.550081999999996 34.0134 16.112222172047886 23.97449233333333 26.1579 11.902636075147813 56.255206666666666 48.4857 34.95099654095751 12.54415;41.2009;60.1903;24.2519;49.3339;34.4455;41.6322;25.231;34.0134;28.1893;3.54778;58.0729;27.1843;13.6362;34.7775 7.348245;31.4864;43.9036;19.7133;35.4173;26.6907;30.9494;13.6792;26.1579;23.1774;1.51564;40.0757;21.5215;11.3249;26.6562 25.495849999999997;60.0774;101.057;31.358;80.9924;48.4857;63.3196;131.659;48.3681;35.9474;8.55785;105.112;36.6615;16.9658;49.7705 4 360243;24950;24484;114494 TOP2A_10059;SRD5A1_32503;IGFBP3_8881;CCNA2_8221 46.984725 51.886250000000004 11.963464240866859 28.850075000000004 29.61945 9.361241663146677 108.40915000000001 87.5632 76.78706769317775 54.9577;29.2087;50.946;52.8265 18.8326;22.9308;36.3081;37.3288 218.525;39.9852;85.0816;90.0448 0 Exp 2,6(0.3);Exp 4,1(0.05);Hill,1(0.05);Linear,10(0.5);Poly 2,2(0.1) 1.9959441685407155 41.87527084350586 1.5124053955078125 4.473705768585205 0.7755593978085281 1.8279361724853516 28.306179936243353 42.87172848480927 19.89451074991321 30.107350829034154 45.16055137364111 89.30941704741153 UP 0.7894736842105263 0.21052631578947367 0.0 GO:0006529 7 asparagine biosynthetic process 1 1 1 1 1 1 1 1 95 0 2451 1.0 0.037691 0.037691 100.0 25612 asns ASNS_8091 28.1893 28.1893 28.1893 28.1893 23.1774 23.1774 23.1774 23.1774 35.9474 35.9474 35.9474 35.9474 0.0 28.1893 0.0 28.1893 28.1893 23.1774 35.9474 1 0 1 25612 ASNS_8091 28.1893 28.1893 23.1774 23.1774 35.9474 35.9474 28.1893 23.1774 35.9474 0 0 Exp 2,1(1) 3.2609751224517822 3.2609751224517822 3.2609751224517822 3.2609751224517822 0.0 3.2609751224517822 28.1893 28.1893 23.1774 23.1774 35.9474 35.9474 UP 1.0 0.0 0.0 GO:0070981 7 L-asparagine biosynthetic process 1 1 1 1 1 1 1 1 95 0 2451 1.0 0.037691 0.037691 100.0 25612 asns ASNS_8091 28.1893 28.1893 28.1893 28.1893 23.1774 23.1774 23.1774 23.1774 35.9474 35.9474 35.9474 35.9474 0.0 28.1893 0.0 28.1893 28.1893 23.1774 35.9474 1 0 1 25612 ASNS_8091 28.1893 28.1893 23.1774 23.1774 35.9474 35.9474 28.1893 23.1774 35.9474 0 0 Exp 2,1(1) 3.2609751224517822 3.2609751224517822 3.2609751224517822 3.2609751224517822 0.0 3.2609751224517822 28.1893 28.1893 23.1774 23.1774 35.9474 35.9474 UP 1.0 0.0 0.0 GO:0070982 7 L-asparagine metabolic process 1 1 1 1 1 1 1 1 95 0 2451 1.0 0.037691 0.037691 100.0 25612 asns ASNS_8091 28.1893 28.1893 28.1893 28.1893 23.1774 23.1774 23.1774 23.1774 35.9474 35.9474 35.9474 35.9474 0.0 28.1893 0.0 28.1893 28.1893 23.1774 35.9474 1 0 1 25612 ASNS_8091 28.1893 28.1893 23.1774 23.1774 35.9474 35.9474 28.1893 23.1774 35.9474 0 0 Exp 2,1(1) 3.2609751224517822 3.2609751224517822 3.2609751224517822 3.2609751224517822 0.0 3.2609751224517822 28.1893 28.1893 23.1774 23.1774 35.9474 35.9474 UP 1.0 0.0 0.0 GO:0045600 7 positive regulation of fat cell differentiation 16 17 3 2 3 3 2 2 94 15 2436 0.97597 0.13262 0.13262 11.76 360268;25664 sult1e1;pparg SULT1E1_32446;PPARG_32510 25664(0.0441) 59.7316 59.7316 59.2729 0.6486997610602128 59.71783430715016 0.6484075812330654 44.6075 44.6075 43.9036 0.9954649265541883 44.6286242014323 0.9950165607805481 96.3074 96.3074 91.5578 6.71694873584721 96.16486340798001 6.713923365653457 0.0 59.2729 0.5 59.7316 59.2729;60.1903 45.3114;43.9036 91.5578;101.057 2 0 2 360268;25664 SULT1E1_32446;PPARG_32510 59.7316 59.7316 0.6486997610602128 44.6075 44.6075 0.9954649265541883 96.3074 96.3074 6.71694873584721 59.2729;60.1903 45.3114;43.9036 91.5578;101.057 0 0 Exp 2,2(1) 2.1187281030698877 4.469563007354736 1.5239794254302979 2.9455835819244385 1.0052259392199887 2.234781503677368 58.832548 60.630652 43.227856 45.987144 86.998184 105.61661600000001 UP 1.0 0.0 0.0 GO:0006955 3 immune response 185 212 7 7 7 7 7 7 89 205 2246 0.44568 0.70074 0.85139 3.3 29142;365813;84386;309607;24614;63868;25599 vnn1;trim59;slpi;rt1-ce5;orm1;hspd1;cd74 VNN1_10157;TRIM59_10085;SLPI_9890;RT1-CE5_32445;ORM1_9400;HSPD1_8849;CD74_8252 48.433614285714285 53.7429 20.7328 25.286188648840742 52.48829659053798 25.20220978130486 31.440642857142855 26.6907 16.8296 14.094331828180335 33.89223219394308 14.258640288281162 83.95007142857142 92.543 26.7838 48.47145346128017 90.03109652957698 45.07388734530166 20.7328;56.1278;53.7429;54.8206;24.2519;34.4455;94.9138 16.8296;33.6269;37.8192;26.5902;19.7133;26.6907;58.8146 26.7838;121.883;92.543;147.824;31.358;48.4857;118.773 4 3 4 29142;24614;63868;25599 VNN1_10157;ORM1_9400;HSPD1_8849;CD74_8252 43.586 29.3487 34.70911487462624 30.512050000000002 23.201999999999998 19.317172773553928 56.350125 39.92185 42.650667794176066 20.7328;24.2519;34.4455;94.9138 16.8296;19.7133;26.6907;58.8146 26.7838;31.358;48.4857;118.773 3 365813;84386;309607 TRIM59_10085;SLPI_9890;RT1-CE5_32445 54.8971 54.8206 1.1942889893152324 32.67876666666667 33.6269 5.674224868943163 120.75 121.883 27.657910387446147 56.1278;53.7429;54.8206 33.6269;37.8192;26.5902 121.883;92.543;147.824 0 Exp 2,4(0.58);Linear,2(0.29);Poly 2,1(0.15) 2.160250246100179 16.597363710403442 1.528815746307373 4.608505725860596 1.218969954604056 1.714035153388977 29.701343590255146 67.16588498117342 20.999415721506367 41.88186999277936 48.04191619614272 119.85822666100015 CONFLICT 0.5714285714285714 0.42857142857142855 0.0 GO:0009059 5 macromolecule biosynthetic process 162 182 7 7 5 7 5 5 91 177 2274 0.30509 0.8292 0.54929 2.75 78968;25664;313245;362094;65155 srebf1;pparg;polr1e;mrps2;alas1 SREBF1_32750;PPARG_32510;POLR1E_9523;MRPS2_9250;ALAS1_8018 25664(0.0441) 53.174659999999996 60.1903 27.1843 18.734173750475378 51.96694129371711 15.605350299561595 37.96867999999999 43.9036 21.5215 11.120731055870397 37.97444639740018 9.863591799842855 94.95258000000001 101.057 36.6615 49.812513206342025 87.00538878675333 36.80770537007503 41.2009;60.1903;73.982;63.3158;27.1843 31.4864;43.9036;47.589;45.3429;21.5215 60.0774;101.057;165.722;111.245;36.6615 5 0 5 78968;25664;313245;362094;65155 SREBF1_32750;PPARG_32510;POLR1E_9523;MRPS2_9250;ALAS1_8018 53.174659999999996 60.1903 18.734173750475378 37.96867999999999 43.9036 11.120731055870397 94.95258000000001 101.057 49.812513206342025 41.2009;60.1903;73.982;63.3158;27.1843 31.4864;43.9036;47.589;45.3429;21.5215 60.0774;101.057;165.722;111.245;36.6615 0 0 Exp 2,3(0.6);Linear,2(0.4) 1.655532584766625 8.321993947029114 1.5184675455093384 1.912555456161499 0.19484072775793074 1.5277283191680908 36.7534326847248 69.59588731527519 28.22092944463568 47.71643055536432 51.28998706148116 138.61517293851884 UP 1.0 0.0 0.0 GO:0032369 6 negative regulation of lipid transport 13 14 3 3 3 3 3 3 93 11 2440 0.99858 0.013961 0.013961 21.43 24484;25649;114628 igfbp3;apoa2;abcg5 IGFBP3_8881;APOA2_33095;ABCG5_7947 29.201893333333334 33.1119 3.54778 23.93979801276805 28.327055734750218 22.296455208391382 20.677846666666667 24.2098 1.51564 17.663092565418253 20.13605183726624 16.51586650928633 48.024116666666664 50.4329 8.55785 38.31869982627064 46.01962655362817 35.34807151723466 0.0 3.54778 0.5 18.32984 50.946;3.54778;33.1119 36.3081;1.51564;24.2098 85.0816;8.55785;50.4329 1 2 1 25649 APOA2_33095 3.54778 3.54778 1.51564 1.51564 8.55785 8.55785 3.54778 1.51564 8.55785 2 24484;114628 IGFBP3_8881;ABCG5_7947 42.028949999999995 42.028949999999995 12.610613046359013 30.258950000000002 30.258950000000002 8.554789970829193 67.75725 67.75725 24.50033072929834 50.946;33.1119 36.3081;24.2098 85.0816;50.4329 0 Exp 2,1(0.34);Hill,1(0.34);Linear,1(0.34) 1.9657964840993833 5.9962382316589355 1.7262524366378784 2.5319817066192627 0.46183298136415046 1.7380040884017944 2.111461632380202 56.29232503428646 0.6901758218302767 40.665517511503054 4.662425813666786 91.38580751966654 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0071241 5 cellular response to inorganic substance 104 113 4 4 2 4 2 2 94 111 2340 0.19054 0.93362 0.44169 1.77 25664;114494 pparg;ccna2 PPARG_32510;CCNA2_8221 25664(0.0441) 56.5084 56.5084 52.8265 5.206992915301499 57.90656349745331 4.816954731858797 40.6162 40.6162 37.3288 4.6490856649453 41.86455619694397 4.300838421878089 95.5509 95.5509 90.0448 7.786801295782564 97.64178460667799 7.203518414158296 60.1903;52.8265 43.9036;37.3288 101.057;90.0448 1 1 1 25664 PPARG_32510 60.1903 60.1903 43.9036 43.9036 101.057 101.057 60.1903 43.9036 101.057 1 114494 CCNA2_8221 52.8265 52.8265 37.3288 37.3288 90.0448 90.0448 52.8265 37.3288 90.0448 0 Exp 2,1(0.5);Linear,1(0.5) 1.8825948863410567 3.8495774269104004 1.5239794254302979 2.3255980014801025 0.5668299310499211 1.9247887134552002 49.291876 63.724924 34.172896 47.059504 84.75894399999999 106.34285600000001 CONFLICT 0.5 0.5 0.0 GO:0046596 6 regulation of viral entry into host cell 10 10 2 2 2 2 2 2 94 8 2443 0.99486 0.051951 0.051951 20.0 365813;25599 trim59;cd74 TRIM59_10085;CD74_8252 75.5208 75.5208 56.1278 27.425843615101428 76.80460351828583 27.365682798952342 46.220749999999995 46.220749999999995 33.6269 17.810393472492425 47.05445437471066 17.77132492742671 120.328 120.328 118.773 2.199102089488896 120.22506004893856 2.194278180392862 0.0 56.1278 0.0 56.1278 56.1278;94.9138 33.6269;58.8146 121.883;118.773 1 1 1 25599 CD74_8252 94.9138 94.9138 58.8146 58.8146 118.773 118.773 94.9138 58.8146 118.773 1 365813 TRIM59_10085 56.1278 56.1278 33.6269 33.6269 121.883 121.883 56.1278 33.6269 121.883 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.59197055959142 3.18655002117157 1.528815746307373 1.6577342748641968 0.09115916576312164 1.593275010585785 37.51052 113.53107999999999 21.536803999999993 70.904696 117.28020000000001 123.3758 CONFLICT 0.5 0.5 0.0 GO:0050789 3 regulation of biological process 1644 1779 69 68 53 68 52 52 44 1727 724 6.9249E-4 0.99968 9.5389E-4 2.92 257644;29142;365813;360243;361604;360268;78968;64159;84386;299270;309607;24679;308761;25664;296371;363465;54133;24614;338475;65035;259241;291234;24552;315994;25626;303575;24484;25685;63868;24471;102551184;29455;299626;58868;65030;117543;25427;65210;25413;306575;64515;25599;362485;114494;25612;25649;155423;502970;81633;50559;170465;114628 zwint;vnn1;trim59;top2a;sytl2;sult1e1;srebf1;sptan1;slpi;serpina6;rt1-ce5;prkar2b;prc1;pparg;pltp;pir;pdlim1;orm1;nrep;nr1i3;nr1d2;mki67;me1;mapkapk3;krt8;kif18b;igfbp3;igfbp1;hspd1;hspb1;loc102551184;gdf15;gadd45b;fzd1;ephx2;decr1;cyp51;cyp2j4;cpt2;ckap2;cdc20;cd74;ccne2;ccna2;asns;apoa2;anxa7;angptl3;acta2;acot1;acaa2;abcg5 ZWINT_10214;VNN1_10157;TRIM59_10085;TOP2A_10059;SYTL2_32351;SULT1E1_32446;SREBF1_32750;SPTAN1_9932;SLPI_9890;SERPINA6_32325;RT1-CE5_32445;PRKAR2B_33052;PRC1_9556;PPARG_32510;PLTP_32412;PIR_9487;PDLIM1_9452;ORM1_9400;NREP_9364;NR1I3_32602;NR1D2_9358;MKI67_9232;ME1_9215;MAPKAPK3_9194;KRT8_8978;KIF18B_32882;IGFBP3_8881;IGFBP1_32306;HSPD1_8849;HSPB1_8847;HIST1H4A_32934;GDF15_33113;GADD45B_8679;FZD1_8671;EPHX2_33282;DECR1_8458;CYP51_8429;CYP2J4_32580;CPT2_8374;CKAP2_8324;CDC20_8255;CD74_8252;CCNE2_8227;CCNA2_8221;ASNS_8091;APOA2_33095;ANXA7_8051;ANGPTL3_8045;ACTA2_33040;ACOT1_7968;ACAA2_7955;ABCG5_7947 25664(0.0441) 55.80589673076923 55.54275 3.54778 26.118391844601828 55.2521588536077 24.72911766695766 36.07339826923077 37.574 1.51564 15.17928962409776 36.053241323975676 14.92010289570876 113.10149134615382 99.91485 8.55785 89.75611562629021 108.45986090034454 82.89196213023264 59.0663;20.7328;56.1278;54.9577;67.0093;59.2729;41.2009;47.5519;53.7429;68.3847;54.8206;108.746;80.3005;60.1903;87.0256;52.1607;67.1147;24.2519;69.4104;22.095;99.0234;49.7822;49.3339;104.193;68.9539;65.9823;50.946;98.8371;34.4455;41.6322;58.3303;21.3654;52.5718;25.231;6.44145;21.6199;75.1522;16.3155;31.2175;64.2131;101.569;94.9138;77.8893;52.8265;28.1893;3.54778;64.7676;58.0729;90.3558;28.5134;78.3988;33.1119 40.5797;16.8296;33.6269;18.8326;44.4373;45.3114;31.4864;34.4152;37.8192;36.9679;26.5902;59.3814;50.2731;43.9036;56.6266;40.9644;47.2419;19.7133;43.1468;12.9529;42.5557;35.6665;35.4173;59.1667;45.3374;43.9552;36.3081;57.328;26.6907;30.9494;40.2068;17.8875;37.1918;13.6792;2.66377;17.4928;48.098;8.2378;24.8356;43.1133;51.5499;58.8146;49.2672;37.3288;23.1774;1.51564;43.3787;40.0757;70.2676;24.741;43.6084;24.2098 108.188;26.7838;121.883;218.525;135.846;91.5578;60.0774;76.6397;92.543;89.5095;147.824;147.467;198.961;101.057;104.563;74.9097;123.914;31.358;157.944;55.8619;102.838;82.1147;80.9924;434.985;143.578;131.93;85.0816;357.409;48.4857;63.3196;105.902;26.3528;89.36;131.659;17.3473;28.0829;171.379;36.8422;42.0237;125.437;453.17;118.773;185.461;90.0448;35.9474;8.55785;127.439;105.112;103.57;33.4642;98.7727;50.4329 32 20 32 257644;29142;360268;78968;64159;299270;24679;25664;296371;363465;54133;24614;65035;259241;24552;25626;25685;63868;24471;29455;299626;58868;65030;117543;65210;25413;25599;25612;25649;155423;502970;50559 ZWINT_10214;VNN1_10157;SULT1E1_32446;SREBF1_32750;SPTAN1_9932;SERPINA6_32325;PRKAR2B_33052;PPARG_32510;PLTP_32412;PIR_9487;PDLIM1_9452;ORM1_9400;NR1I3_32602;NR1D2_9358;ME1_9215;KRT8_8978;IGFBP1_32306;HSPD1_8849;HSPB1_8847;GDF15_33113;GADD45B_8679;FZD1_8671;EPHX2_33282;DECR1_8458;CYP2J4_32580;CPT2_8374;CD74_8252;ASNS_8091;APOA2_33095;ANXA7_8051;ANGPTL3_8045;ACOT1_7968 48.837094687500006 48.4429 28.143598418195296 32.4482596875 34.91625 16.088236649635075 84.04596406250002 78.81605 63.79978283063985 59.0663;20.7328;59.2729;41.2009;47.5519;68.3847;108.746;60.1903;87.0256;52.1607;67.1147;24.2519;22.095;99.0234;49.3339;68.9539;98.8371;34.4455;41.6322;21.3654;52.5718;25.231;6.44145;21.6199;16.3155;31.2175;94.9138;28.1893;3.54778;64.7676;58.0729;28.5134 40.5797;16.8296;45.3114;31.4864;34.4152;36.9679;59.3814;43.9036;56.6266;40.9644;47.2419;19.7133;12.9529;42.5557;35.4173;45.3374;57.328;26.6907;30.9494;17.8875;37.1918;13.6792;2.66377;17.4928;8.2378;24.8356;58.8146;23.1774;1.51564;43.3787;40.0757;24.741 108.188;26.7838;91.5578;60.0774;76.6397;89.5095;147.467;101.057;104.563;74.9097;123.914;31.358;55.8619;102.838;80.9924;143.578;357.409;48.4857;63.3196;26.3528;89.36;131.659;17.3473;28.0829;36.8422;42.0237;118.773;35.9474;8.55785;127.439;105.112;33.4642 20 365813;360243;361604;84386;309607;308761;338475;291234;315994;303575;24484;102551184;25427;306575;64515;362485;114494;81633;170465;114628 TRIM59_10085;TOP2A_10059;SYTL2_32351;SLPI_9890;RT1-CE5_32445;PRC1_9556;NREP_9364;MKI67_9232;MAPKAPK3_9194;KIF18B_32882;IGFBP3_8881;HIST1H4A_32934;CYP51_8429;CKAP2_8324;CDC20_8255;CCNE2_8227;CCNA2_8221;ACTA2_33040;ACAA2_7955;ABCG5_7947 66.95598 65.0977 18.058708834611167 41.873619999999995 43.13005 11.773737055238465 159.590335 128.6835 106.23756520502471 56.1278;54.9577;67.0093;53.7429;54.8206;80.3005;69.4104;49.7822;104.193;65.9823;50.946;58.3303;75.1522;64.2131;101.569;77.8893;52.8265;90.3558;78.3988;33.1119 33.6269;18.8326;44.4373;37.8192;26.5902;50.2731;43.1468;35.6665;59.1667;43.9552;36.3081;40.2068;48.098;43.1133;51.5499;49.2672;37.3288;70.2676;43.6084;24.2098 121.883;218.525;135.846;92.543;147.824;198.961;157.944;82.1147;434.985;131.93;85.0816;105.902;171.379;125.437;453.17;185.461;90.0448;103.57;98.7727;50.4329 0 Exp 2,17(0.33);Exp 4,2(0.04);Hill,1(0.02);Linear,23(0.45);Poly 2,7(0.14);Power,2(0.04) 2.049049872988751 153.5752512216568 1.5062377452850342 50.888092041015625 6.816628074675929 1.768297255039215 48.706836960938084 62.904956500600385 31.947620352037923 40.19917618642361 88.70550122049832 137.4974814718095 UP 0.6153846153846154 0.38461538461538464 0.0 GO:0015722 7 canalicular bile acid transport 4 4 1 1 1 1 1 1 95 3 2448 0.99197 0.14253 0.14253 25.0 140668 abcc3 ABCC3_7941 34.7775 34.7775 34.7775 34.7775 26.6562 26.6562 26.6562 26.6562 49.7705 49.7705 49.7705 49.7705 0.0 34.7775 0.0 34.7775 34.7775 26.6562 49.7705 1 0 1 140668 ABCC3_7941 34.7775 34.7775 26.6562 26.6562 49.7705 49.7705 34.7775 26.6562 49.7705 0 0 Linear,1(1) 1.998015284538269 1.998015284538269 1.998015284538269 1.998015284538269 0.0 1.998015284538269 34.7775 34.7775 26.6562 26.6562 49.7705 49.7705 UP 1.0 0.0 0.0 GO:0050878 4 regulation of body fluid levels 107 110 3 3 2 3 2 2 94 108 2343 0.20554 0.92682 0.43766 1.82 361604;155423 sytl2;anxa7 SYTL2_32351;ANXA7_8051 65.88845 65.88845 64.7676 1.58512127138551 66.430750310559 1.3872383325642563 43.908 43.908 43.3787 0.748543238564181 44.164090961662026 0.655096801022772 131.64249999999998 131.64249999999998 127.439 5.944646709436117 133.67627736131934 5.202530517852355 67.0093;64.7676 44.4373;43.3787 135.846;127.439 1 1 1 155423 ANXA7_8051 64.7676 64.7676 43.3787 43.3787 127.439 127.439 64.7676 43.3787 127.439 1 361604 SYTL2_32351 67.0093 67.0093 44.4373 44.4373 135.846 135.846 67.0093 44.4373 135.846 0 Linear,2(1) 1.5426996038329965 3.0860157012939453 1.512166976928711 1.5738487243652344 0.043615581887801666 1.5430078506469727 63.69158400000001 68.085316 42.870572 44.945428 123.40363999999998 139.88136 CONFLICT 0.5 0.5 0.0 GO:0051188 5 cofactor biosynthetic process 48 53 3 3 3 3 3 3 93 50 2401 0.86306 0.32251 0.45025 5.66 298490;364975;65155 ppcs;gcdh;alas1 PPCS_9540;GCDH_8693;ALAS1_8018 19.398500000000002 15.9021 15.1091 6.7543484867158 19.62012758236511 6.898053426682834 13.294936666666667 10.4227 7.94061 7.23169764993209 13.440725101066368 7.45536801091838 32.858133333333335 31.2818 30.6311 3.3098415556236684 32.95224347445488 3.392043845809484 1.5 21.5432 15.1091;15.9021;27.1843 7.94061;10.4227;21.5215 30.6311;31.2818;36.6615 3 0 3 298490;364975;65155 PPCS_9540;GCDH_8693;ALAS1_8018 19.398500000000002 15.9021 6.7543484867158 13.294936666666667 10.4227 7.23169764993209 32.858133333333335 31.2818 3.3098415556236684 15.1091;15.9021;27.1843 7.94061;10.4227;21.5215 30.6311;31.2818;36.6615 0 0 Hill,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 1.7554504680262115 5.287606120109558 1.5464483499526978 1.9018945693969727 0.18973896107890748 1.8392632007598877 11.755235162668423 27.04176483733158 5.1115004002895645 21.478372933043772 29.112695023629236 36.603571643037434 UP 1.0 0.0 0.0 GO:0090287 5 regulation of cellular response to growth factor stimulus 62 66 2 2 2 2 2 2 94 64 2387 0.54304 0.72003 1.0 3.03 338475;58868 nrep;fzd1 NREP_9364;FZD1_8671 47.3207 47.3207 25.231 31.239553328752958 51.467257256006334 30.684227512279357 28.413 28.413 13.6792 20.8367397852927 31.17874807709232 20.46633821737832 144.80149999999998 144.80149999999998 131.659 18.58630174348852 147.26853797412653 18.25590479183208 69.4104;25.231 43.1468;13.6792 157.944;131.659 1 1 1 58868 FZD1_8671 25.231 25.231 13.6792 13.6792 131.659 131.659 25.231 13.6792 131.659 1 338475 NREP_9364 69.4104 69.4104 43.1468 43.1468 157.944 157.944 69.4104 43.1468 157.944 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.8300315348152543 3.726768970489502 1.5124053955078125 2.2143635749816895 0.496359388815342 1.863384485244751 4.024888000000011 90.616512 -0.465247999999999 57.291247999999996 119.04219999999998 170.56079999999997 CONFLICT 0.5 0.5 0.0 GO:0006475 9 internal protein amino acid acetylation 15 15 1 1 1 1 1 1 95 14 2437 0.89259 0.43894 0.43894 6.67 171142 ehhadh EHHADH_8534 7.29984 7.29984 7.29984 7.29984 5.26587 5.26587 5.26587 5.26587 11.8779 11.8779 11.8779 11.8779 0.0 7.29984 7.29984 5.26587 11.8779 1 0 1 171142 EHHADH_8534 7.29984 7.29984 5.26587 5.26587 11.8779 11.8779 7.29984 5.26587 11.8779 0 0 Hill,1(1) 3.9502921104431152 3.9502921104431152 3.9502921104431152 3.9502921104431152 0.0 3.9502921104431152 7.29984 7.29984 5.26587 5.26587 11.8779 11.8779 UP 1.0 0.0 0.0 GO:0006270 6 DNA replication initiation 12 13 2 2 2 2 2 2 94 11 2440 0.98873 0.083726 0.083726 15.38 316273;362485 mcm3;ccne2 MCM3_9207;CCNE2_8227 65.9469 65.9469 54.0045 16.88910404728447 59.058601405209956 13.796540162592413 41.2631 41.2631 33.259 11.319506774590485 36.646387213411124 9.246791860547827 148.607 148.607 111.753 52.11942662769808 127.34985265839427 42.575838286457035 0.0 54.0045 0.5 65.9469 54.0045;77.8893 33.259;49.2672 111.753;185.461 0 2 0 2 316273;362485 MCM3_9207;CCNE2_8227 65.9469 65.9469 16.88910404728447 41.2631 41.2631 11.319506774590485 148.607 148.607 52.11942662769808 54.0045;77.8893 33.259;49.2672 111.753;185.461 0 Exp 2,1(0.5);Linear,1(0.5) 1.6237374790247519 3.2482001781463623 1.589782476425171 1.6584177017211914 0.048532433235082564 1.6241000890731812 42.539795999999996 89.354004 25.575064 56.951136000000005 76.37316 220.84084000000001 DOWN 0.0 1.0 0.0 GO:0002695 6 negative regulation of leukocyte activation 54 56 3 3 3 3 3 3 93 53 2398 0.84189 0.35402 0.46757 5.36 309607;25664;25599 rt1-ce5;pparg;cd74 RT1-CE5_32445;PPARG_32510;CD74_8252 25664(0.0441) 69.97489999999999 60.1903 54.8206 21.763960334231484 71.0637083414033 21.818555056916292 43.1028 43.9036 26.5902 16.127118444409085 44.527348102825954 15.45831147175027 122.55133333333333 118.773 101.057 23.611330422772365 119.94993881503655 22.715768447107195 1.5 77.55205 54.8206;60.1903;94.9138 26.5902;43.9036;58.8146 147.824;101.057;118.773 2 1 2 25664;25599 PPARG_32510;CD74_8252 77.55205 77.55205 24.55322231653108 51.3591 51.3591 10.543669214272617 109.91499999999999 109.91499999999999 12.527103735500948 60.1903;94.9138 43.9036;58.8146 101.057;118.773 1 309607 RT1-CE5_32445 54.8206 54.8206 26.5902 26.5902 147.824 147.824 54.8206 26.5902 147.824 0 Exp 2,2(0.67);Poly 2,1(0.34) 1.6712035437111106 5.02925443649292 1.5239794254302979 1.8475407361984253 0.16258780926896893 1.6577342748641968 45.34666041910229 94.60313958089769 24.853247496740156 61.35235250325984 95.83259770132827 149.27006896533842 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0000302 5 response to reactive oxygen species 109 115 6 6 4 6 4 4 92 111 2340 0.56121 0.63902 1.0 3.48 63868;24471;25086;114494 hspd1;hspb1;cyp2e1;ccna2 HSPD1_8849;HSPB1_8847;CYP2E1_8421;CCNA2_8221 34.198985 38.03885 7.89174 19.099466916179455 33.765582413323244 18.185550743928395 24.7842175 28.820050000000002 4.16797 14.422671526242693 24.620768297249562 13.847338070975056 54.414500000000004 55.90265 15.8079 30.953940605895923 53.05803871814282 29.028723715214777 34.4455;41.6322;7.89174;52.8265 26.6907;30.9494;4.16797;37.3288 48.4857;63.3196;15.8079;90.0448 3 1 3 63868;24471;25086 HSPD1_8849;HSPB1_8847;CYP2E1_8421 27.98981333333333 34.4455 17.772494985413093 20.60269 26.6907 14.39128720897822 42.537733333333335 48.4857 24.307902826515768 34.4455;41.6322;7.89174 26.6907;30.9494;4.16797 48.4857;63.3196;15.8079 1 114494 CCNA2_8221 52.8265 52.8265 37.3288 37.3288 90.0448 90.0448 52.8265 37.3288 90.0448 0 Exp 2,1(0.25);Exp 4,1(0.25);Linear,2(0.5) 1.816502288838594 7.359225869178772 1.5310101509094238 2.3255980014801025 0.34893542083613854 1.7513088583946228 15.481507422144137 52.91646257785587 10.649999404282166 38.91843559571784 24.07963820622199 84.74936179377802 UP 0.75 0.25 0.0 GO:0061024 5 membrane organization 110 116 6 6 5 6 5 5 91 111 2340 0.72937 0.44636 0.62282 4.31 296371;25649;155423;170465;114628 pltp;apoa2;anxa7;acaa2;abcg5 PLTP_32412;APOA2_33095;ANXA7_8051;ACAA2_7955;ABCG5_7947 53.370335999999995 64.7676 3.54778 34.5748815881339 52.452900509979266 35.45743483491768 33.867828 43.3787 1.51564 21.466477967238124 33.09619179367549 21.665071970979554 77.95309 98.7727 8.55785 47.86297878209734 71.6610908777216 44.10817423660089 87.0256;3.54778;64.7676;78.3988;33.1119 56.6266;1.51564;43.3787;43.6084;24.2098 104.563;8.55785;127.439;98.7727;50.4329 3 2 3 296371;25649;155423 PLTP_32412;APOA2_33095;ANXA7_8051 51.78032666666667 64.7676 43.22775219074122 33.840313333333334 43.3787 28.76699659649116 80.18661666666667 104.563 63.078031077712254 87.0256;3.54778;64.7676 56.6266;1.51564;43.3787 104.563;8.55785;127.439 2 170465;114628 ACAA2_7955;ABCG5_7947 55.75534999999999 55.75534999999999 32.02267408891706 33.9091 33.9091 13.716881605525355 74.6028 74.6028 34.18140038120146 78.3988;33.1119 43.6084;24.2098 98.7727;50.4329 0 Exp 2,1(0.2);Hill,1(0.2);Linear,1(0.2);Poly 2,2(0.4) 1.7813641348684683 9.069179654121399 1.5084086656570435 2.5319817066192627 0.41277537682812815 1.7262524366378784 23.064116066331284 83.67655593366872 15.051630442879585 52.68402555712042 35.999339328339296 119.90684067166069 UP 0.6 0.4 0.0 GO:0046144 10 D-alanine family amino acid metabolic process 1 1 1 1 1 1 1 1 95 0 2451 1.0 0.037691 0.037691 100.0 114027 dao DAO_8437 6.1336 6.1336 6.1336 6.1336 2.43617 2.43617 2.43617 2.43617 16.2027 16.2027 16.2027 16.2027 0.0 6.1336 0.0 6.1336 6.1336 2.43617 16.2027 1 0 1 114027 DAO_8437 6.1336 6.1336 2.43617 2.43617 16.2027 16.2027 6.1336 2.43617 16.2027 0 0 Hill,1(1) 2.0627336502075195 2.0627336502075195 2.0627336502075195 2.0627336502075195 0.0 2.0627336502075195 6.1336 6.1336 2.43617 2.43617 16.2027 16.2027 UP 1.0 0.0 0.0 GO:0048512 4 circadian behavior 13 13 2 2 2 2 2 2 94 11 2440 0.98873 0.083726 0.083726 15.38 24950;259241 srd5a1;nr1d2 SRD5A1_32503;NR1D2_9358 64.11605 64.11605 29.2087 49.366447796504445 62.33396500066998 49.302074136443046 32.74325 32.74325 22.9308 13.876899870107875 32.24230621733888 13.858804445486129 71.41159999999999 71.41159999999999 39.9852 44.44364109656185 69.80722395819376 44.385686757703255 0.0 29.2087 0.5 64.11605 29.2087;99.0234 22.9308;42.5557 39.9852;102.838 1 1 1 259241 NR1D2_9358 99.0234 99.0234 42.5557 42.5557 102.838 102.838 99.0234 42.5557 102.838 1 24950 SRD5A1_32503 29.2087 29.2087 22.9308 22.9308 39.9852 39.9852 29.2087 22.9308 39.9852 0 Linear,1(0.5);Power,1(0.5) 2.3067838382664494 4.678335666656494 1.9512832164764404 2.7270524501800537 0.5485516857877165 2.339167833328247 -4.302355999999975 132.53445599999998 13.510848000000003 51.975652000000004 9.815855999999997 133.007344 CONFLICT 0.5 0.5 0.0 GO:0044248 4 cellular catabolic process 306 344 34 33 31 34 30 30 66 314 2137 1.0 3.526E-6 4.1956E-6 8.72 286954;360268;64305;364975;65030;25315;171142;291075;29740;64526;117543;114027;65210;25086;24303;499353;171521;29277;24894;311849;25413;64515;25649;155423;502970;26760;50681;681337;192272;170465 ugt2b1;sult1e1;sult1b1;gcdh;ephx2;ephx1;ehhadh;eci2;eci1;ech1;decr1;dao;cyp2j4;cyp2e1;cyp2d3;cyp2c24;cyp2c13;cyp2c11;cyp2a1;crat;cpt2;cdc20;apoa2;anxa7;angptl3;akr7a3;acox1;acot4;acot2;acaa2 UGT2B10_33303,UGT2B1_33224;SULT1E1_32446;SULT1B1_32942;GCDH_8693;EPHX2_33282;EPHX1_8567;EHHADH_8534;ECI2_8521;ECI1_8520;ECH1_8516;DECR1_8458;DAO_8437;CYP2J4_32580;CYP2E1_8421;CYP2D3_8420;CYP2C24_32875;CYP2C13_8419;CYP2C11_32593;CYP2A1_32717;CRAT_8375;CPT2_8374;CDC20_8255;APOA2_33095;ANXA7_8051;ANGPTL3_8045;AKR7A3_8015;ACOX1_7973;ACOT4_7971;ACOT2_7969;ACAA2_7955 29.619320000000002 15.682500000000001 3.54778 28.907535740541118 32.24893211754603 29.776233152859007 18.9365065 9.64455 1.51564 17.512024734469286 20.631331038323236 18.095737266956494 57.00578333333333 31.31805 8.55785 81.93614595620024 58.2095952436799 74.41751235355802 16.5 17.56725 12.54415;59.2729;15.4629;15.9021;6.44145;34.0134;7.29984;8.72912;11.7653;9.87438;21.6199;6.1336;16.3155;7.89174;12.8059;58.9435;104.635;54.426;9.37187;8.98517;31.2175;101.569;3.54778;64.7676;58.0729;18.819;23.8014;12.3157;13.6362;78.3988 7.348245;45.3114;7.69418;10.4227;2.66377;26.1579;5.26587;5.10151;8.40998;6.59127;17.4928;2.43617;8.2378;4.16797;8.8664;48.1505;49.2461;43.9518;4.95906;1.97988;24.8356;51.5499;1.51564;43.3787;40.0757;11.5469;19.0993;6.70485;11.3249;43.6084 25.495849999999997;91.5578;35.0879;31.2818;17.3473;48.3681;11.8779;17.7951;18.8402;19.44;28.0829;16.2027;36.8422;15.8079;22.6004;80.4167;108.327;74.8861;19.1079;31.3726;42.0237;453.17;8.55785;127.439;105.112;51.6405;31.3543;24.3993;16.9658;98.7727 29 2 28 286954;360268;64305;364975;65030;25315;171142;291075;29740;64526;117543;114027;65210;25086;24303;499353;171521;29277;24894;311849;25413;25649;155423;502970;26760;50681;681337;192272 UGT2B10_33303,UGT2B1_33224;SULT1E1_32446;SULT1B1_32942;GCDH_8693;EPHX2_33282;EPHX1_8567;EHHADH_8534;ECI2_8521;ECI1_8520;ECH1_8516;DECR1_8458;DAO_8437;CYP2J4_32580;CYP2E1_8421;CYP2D3_8420;CYP2C24_32875;CYP2C13_8419;CYP2C11_32593;CYP2A1_32717;CRAT_8375;CPT2_8374;APOA2_33095;ANXA7_8051;ANGPTL3_8045;AKR7A3_8015;ACOX1_7973;ACOT4_7971;ACOT2_7969 25.307564285714285 14.54955 24.46234770269629 16.89060339285714 8.63819 16.220612615264844 41.365385714285715 29.68235 32.85909844149336 12.54415;59.2729;15.4629;15.9021;6.44145;34.0134;7.29984;8.72912;11.7653;9.87438;21.6199;6.1336;16.3155;7.89174;12.8059;58.9435;104.635;54.426;9.37187;8.98517;31.2175;3.54778;64.7676;58.0729;18.819;23.8014;12.3157;13.6362 7.348245;45.3114;7.69418;10.4227;2.66377;26.1579;5.26587;5.10151;8.40998;6.59127;17.4928;2.43617;8.2378;4.16797;8.8664;48.1505;49.2461;43.9518;4.95906;1.97988;24.8356;1.51564;43.3787;40.0757;11.5469;19.0993;6.70485;11.3249 25.495849999999997;91.5578;35.0879;31.2818;17.3473;48.3681;11.8779;17.7951;18.8402;19.44;28.0829;16.2027;36.8422;15.8079;22.6004;80.4167;108.327;74.8861;19.1079;31.3726;42.0237;8.55785;127.439;105.112;51.6405;31.3543;24.3993;16.9658 2 64515;170465 CDC20_8255;ACAA2_7955 89.9839 89.9839 16.38380554144852 47.57915 47.57915 5.615488502793055 275.97135000000003 275.97135000000003 250.59673406420325 101.569;78.3988 51.5499;43.6084 453.17;98.7727 0 Exp 2,5(0.17);Exp 4,6(0.2);Hill,7(0.23);Linear,6(0.2);Poly 2,6(0.2);Power,1(0.04) 2.06912774879107 67.74078333377838 1.5293418169021606 4.473705768585205 0.8069377249156705 1.7483696937561035 19.27489118743896 39.963748812561036 12.669908929890598 25.203104070109397 27.685310062038916 86.32625660462776 UP 0.9333333333333333 0.06666666666666667 0.0 GO:0050807 6 regulation of synapse organization 52 60 2 2 2 2 2 2 94 58 2393 0.60424 0.66936 1.0 3.33 58868;64515 fzd1;cdc20 FZD1_8671;CDC20_8255 63.400000000000006 63.400000000000006 25.231 53.97911746221864 64.7675929175807 53.94445755796942 32.61455 32.61455 13.6792 26.77862877828138 33.29300242348271 26.76143426393924 292.4145 292.4145 131.659 227.34260832606816 298.1743596573697 227.19663200398645 25.231;101.569 13.6792;51.5499 131.659;453.17 1 1 1 58868 FZD1_8671 25.231 25.231 13.6792 13.6792 131.659 131.659 25.231 13.6792 131.659 1 64515 CDC20_8255 101.569 101.569 51.5499 51.5499 453.17 453.17 101.569 51.5499 453.17 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.5208500305613795 3.041747212409973 1.5124053955078125 1.5293418169021606 0.011975858416976496 1.5208736062049866 -11.411239999999985 138.21123999999998 -4.498735999999994 69.727836 -22.66628000000003 607.49528 CONFLICT 0.5 0.5 0.0 GO:0043933 5 protein-containing complex subunit organization 226 259 11 11 7 11 7 7 89 252 2199 0.22309 0.87263 0.48896 2.7 313245;296371;316273;303575;102551184;25599;25649 polr1e;pltp;mcm3;kif18b;loc102551184;cd74;apoa2 POLR1E_9523;PLTP_32412;MCM3_9207;KIF18B_32882;HIST1H4A_32934;CD74_8252;APOA2_33095 62.54089714285714 65.9823 3.54778 29.891567027966097 63.480342683319705 30.71246777785596 40.28097714285714 43.9552 1.51564 19.27713111230481 40.48657995377612 19.790027464016955 106.74297857142857 111.753 8.55785 48.181102401113144 103.58236184311896 43.87445317976155 73.982;87.0256;54.0045;65.9823;58.3303;94.9138;3.54778 47.589;56.6266;33.259;43.9552;40.2068;58.8146;1.51564 165.722;104.563;111.753;131.93;105.902;118.773;8.55785 4 3 4 313245;296371;25599;25649 POLR1E_9523;PLTP_32412;CD74_8252;APOA2_33095 64.867295 80.5038 41.78095144225536 41.13646 52.1078 26.857064377944702 99.4039625 111.668 65.96179079794824 73.982;87.0256;94.9138;3.54778 47.589;56.6266;58.8146;1.51564 165.722;104.563;118.773;8.55785 3 316273;303575;102551184 MCM3_9207;KIF18B_32882;HIST1H4A_32934 59.43903333333333 58.3303 6.065384605557451 39.14033333333333 40.2068 5.427263304220018 116.52833333333335 111.753 13.655293930682333 54.0045;65.9823;58.3303 33.259;43.9552;40.2068 111.753;131.93;105.902 0 Exp 2,1(0.15);Hill,1(0.15);Linear,3(0.43);Poly 2,2(0.29) 1.633313553705422 11.447922229766846 1.5084086656570435 1.7262524366378784 0.08869125824009441 1.6577342748641968 40.396914399732545 84.68487988598173 26.000278566952684 54.56167571876159 71.04991841446953 142.43603872838764 CONFLICT 0.5714285714285714 0.42857142857142855 0.0 GO:0002439 5 chronic inflammatory response to antigenic stimulus 2 3 1 1 1 1 1 1 95 2 2449 0.99588 0.10891 0.10891 33.33 24614 orm1 ORM1_9400 24.2519 24.2519 24.2519 24.2519 19.7133 19.7133 19.7133 19.7133 31.358 31.358 31.358 31.358 0.0 24.2519 0.0 24.2519 24.2519 19.7133 31.358 1 0 1 24614 ORM1_9400 24.2519 24.2519 19.7133 19.7133 31.358 31.358 24.2519 19.7133 31.358 0 0 Exp 2,1(1) 3.5849626064300537 3.5849626064300537 3.5849626064300537 3.5849626064300537 0.0 3.5849626064300537 24.2519 24.2519 19.7133 19.7133 31.358 31.358 UP 1.0 0.0 0.0 GO:0015718 8 monocarboxylic acid transport 51 54 4 4 3 4 3 3 93 51 2400 0.85614 0.33302 0.45585 5.56 25664;25413;140668 pparg;cpt2;abcc3 PPARG_32510;CPT2_8374;ABCC3_7941 25664(0.0441) 42.06176666666667 34.7775 31.2175 15.800354129364736 46.68546631232748 16.648927053876797 31.798466666666666 26.6562 24.8356 10.522800760887446 34.87644604451753 11.109126355583378 64.28373333333333 49.7705 42.0237 32.081273097608396 73.6717080871557 33.78270381582002 1.5 47.483900000000006 60.1903;31.2175;34.7775 43.9036;24.8356;26.6562 101.057;42.0237;49.7705 3 0 3 25664;25413;140668 PPARG_32510;CPT2_8374;ABCC3_7941 42.06176666666667 34.7775 15.800354129364736 31.798466666666666 26.6562 10.522800760887446 64.28373333333333 49.7705 32.081273097608396 60.1903;31.2175;34.7775 43.9036;24.8356;26.6562 101.057;42.0237;49.7705 0 0 Exp 2,2(0.67);Linear,1(0.34) 1.7878923658044035 5.398916602134705 1.5239794254302979 1.998015284538269 0.24628641531829112 1.8769218921661377 24.181982795301582 59.94155053803176 19.890796636889426 43.706136696443906 27.980355281987094 100.58711138467956 UP 1.0 0.0 0.0 GO:0048518 4 positive regulation of biological process 1152 1238 45 44 33 44 32 32 64 1206 1245 0.0014692 0.99928 0.002428 2.58 29142;360243;361604;360268;78968;309607;308761;25664;296371;54133;24614;65035;259241;24484;25685;63868;24471;29455;299626;58868;65030;117543;65210;25413;306575;64515;25599;114494;25612;25649;502970;81633 vnn1;top2a;sytl2;sult1e1;srebf1;rt1-ce5;prc1;pparg;pltp;pdlim1;orm1;nr1i3;nr1d2;igfbp3;igfbp1;hspd1;hspb1;gdf15;gadd45b;fzd1;ephx2;decr1;cyp2j4;cpt2;ckap2;cdc20;cd74;ccna2;asns;apoa2;angptl3;acta2 VNN1_10157;TOP2A_10059;SYTL2_32351;SULT1E1_32446;SREBF1_32750;RT1-CE5_32445;PRC1_9556;PPARG_32510;PLTP_32412;PDLIM1_9452;ORM1_9400;NR1I3_32602;NR1D2_9358;IGFBP3_8881;IGFBP1_32306;HSPD1_8849;HSPB1_8847;GDF15_33113;GADD45B_8679;FZD1_8671;EPHX2_33282;DECR1_8458;CYP2J4_32580;CPT2_8374;CKAP2_8324;CDC20_8255;CD74_8252;CCNA2_8221;ASNS_8091;APOA2_33095;ANGPTL3_8045;ACTA2_33040 25664(0.0441) 51.0095978125 52.69915 3.54778 28.622846085840276 50.71520445889379 27.032034141627804 32.9956940625 33.89725 1.51564 17.41414612370234 33.449081175218275 17.262539913961835 105.17946093750001 90.8013 8.55785 94.27955503201099 98.24703429801879 79.39068736352114 20.7328;54.9577;67.0093;59.2729;41.2009;54.8206;80.3005;60.1903;87.0256;67.1147;24.2519;22.095;99.0234;50.946;98.8371;34.4455;41.6322;21.3654;52.5718;25.231;6.44145;21.6199;16.3155;31.2175;64.2131;101.569;94.9138;52.8265;28.1893;3.54778;58.0729;90.3558 16.8296;18.8326;44.4373;45.3114;31.4864;26.5902;50.2731;43.9036;56.6266;47.2419;19.7133;12.9529;42.5557;36.3081;57.328;26.6907;30.9494;17.8875;37.1918;13.6792;2.66377;17.4928;8.2378;24.8356;43.1133;51.5499;58.8146;37.3288;23.1774;1.51564;40.0757;70.2676 26.7838;218.525;135.846;91.5578;60.0774;147.824;198.961;101.057;104.563;123.914;31.358;55.8619;102.838;85.0816;357.409;48.4857;63.3196;26.3528;89.36;131.659;17.3473;28.0829;36.8422;42.0237;125.437;453.17;118.773;90.0448;35.9474;8.55785;105.112;103.57 23 9 23 29142;360268;78968;25664;296371;54133;24614;65035;259241;25685;63868;24471;29455;299626;58868;65030;117543;65210;25413;25599;25612;25649;502970 VNN1_10157;SULT1E1_32446;SREBF1_32750;PPARG_32510;PLTP_32412;PDLIM1_9452;ORM1_9400;NR1I3_32602;NR1D2_9358;IGFBP1_32306;HSPD1_8849;HSPB1_8847;GDF15_33113;GADD45B_8679;FZD1_8671;EPHX2_33282;DECR1_8458;CYP2J4_32580;CPT2_8374;CD74_8252;ASNS_8091;APOA2_33095;ANGPTL3_8045 44.14385347826087 34.4455 29.300193549327467 29.44179608695652 26.6907 17.28599359788695 78.57753695652174 60.0774 71.58177079054448 20.7328;59.2729;41.2009;60.1903;87.0256;67.1147;24.2519;22.095;99.0234;98.8371;34.4455;41.6322;21.3654;52.5718;25.231;6.44145;21.6199;16.3155;31.2175;94.9138;28.1893;3.54778;58.0729 16.8296;45.3114;31.4864;43.9036;56.6266;47.2419;19.7133;12.9529;42.5557;57.328;26.6907;30.9494;17.8875;37.1918;13.6792;2.66377;17.4928;8.2378;24.8356;58.8146;23.1774;1.51564;40.0757 26.7838;91.5578;60.0774;101.057;104.563;123.914;31.358;55.8619;102.838;357.409;48.4857;63.3196;26.3528;89.36;131.659;17.3473;28.0829;36.8422;42.0237;118.773;35.9474;8.55785;105.112 9 360243;361604;309607;308761;24484;306575;64515;114494;81633 TOP2A_10059;SYTL2_32351;RT1-CE5_32445;PRC1_9556;IGFBP3_8881;CKAP2_8324;CDC20_8255;CCNA2_8221;ACTA2_33040 68.55538888888888 64.2131 18.21874046664898 42.07787777777778 43.1133 14.975961825854283 173.1621555555556 135.846 114.53695703941051 54.9577;67.0093;54.8206;80.3005;50.946;64.2131;101.569;52.8265;90.3558 18.8326;44.4373;26.5902;50.2731;36.3081;43.1133;51.5499;37.3288;70.2676 218.525;135.846;147.824;198.961;85.0816;125.437;453.17;90.0448;103.57 0 Exp 2,12(0.38);Exp 4,2(0.07);Hill,1(0.04);Linear,11(0.35);Poly 2,5(0.16);Power,1(0.04) 2.038536671814754 69.1615629196167 1.5084086656570435 5.015069484710693 0.8736146709222677 1.847194492816925 41.09228761606331 60.92690800893666 26.962000264304756 39.029387860695245 72.51326171921121 137.84566015578878 UP 0.71875 0.28125 0.0 GO:0051791 7 medium-chain fatty acid metabolic process 7 8 4 4 2 4 2 2 94 6 2445 0.99747 0.033945 0.033945 25.0 50549;311849 cyp4a1;crat CYP4A1_33111;CRAT_8375 16.096584999999997 16.096584999999997 8.98517 10.057059540663461 11.17582410691606 7.260624702506079 10.42144 10.42144 1.97988 11.938168639586225 4.580282041334718 8.618678429495004 30.67895 30.67895 29.9853 0.9809692375400535 31.158922803371432 0.708203968534275 0.0 8.98517 0.0 8.98517 23.208;8.98517 18.863;1.97988 29.9853;31.3726 2 0 2 50549;311849 CYP4A1_33111;CRAT_8375 16.096584999999997 16.096584999999997 10.057059540663461 10.42144 10.42144 11.938168639586225 30.67895 30.67895 0.9809692375400535 23.208;8.98517 18.863;1.97988 29.9853;31.3726 0 0 Exp 2,1(0.5);Hill,1(0.5) 1.8761806604321003 3.7659082412719727 1.7233848571777344 2.0425233840942383 0.22566501652054544 1.8829541206359863 2.1582115999999996 30.034958399999994 -6.124017599999995 26.966897599999996 29.319396 32.038504 UP 1.0 0.0 0.0 GO:0046836 7 glycolipid transport 1 1 1 1 1 1 1 1 95 0 2451 1.0 0.037691 0.037691 100.0 296371 pltp PLTP_32412 87.0256 87.0256 87.0256 87.0256 56.6266 56.6266 56.6266 56.6266 104.563 104.563 104.563 104.563 0.0 87.0256 0.0 87.0256 87.0256 56.6266 104.563 1 0 1 296371 PLTP_32412 87.0256 87.0256 56.6266 56.6266 104.563 104.563 87.0256 56.6266 104.563 0 0 Poly 2,1(1) 1.5084086656570435 1.5084086656570435 1.5084086656570435 1.5084086656570435 0.0 1.5084086656570435 87.0256 87.0256 56.6266 56.6266 104.563 104.563 UP 1.0 0.0 0.0 GO:0009395 6 phospholipid catabolic process 8 9 2 2 2 2 2 2 94 7 2444 0.9963 0.042588 0.042588 22.22 25649;502970 apoa2;angptl3 APOA2_33095;ANGPTL3_8045 30.81034 30.81034 3.54778 38.55508209701024 37.456113148345786 37.392001203849105 20.795669999999998 20.795669999999998 1.51564 27.266079908960144 25.495547989202088 26.443551338181244 56.834925 56.834925 8.55785 68.27409421670308 68.6033902034026 66.21448780005667 0.0 3.54778 0.0 3.54778 3.54778;58.0729 1.51564;40.0757 8.55785;105.112 2 0 2 25649;502970 APOA2_33095;ANGPTL3_8045 30.81034 30.81034 38.55508209701024 20.795669999999998 20.795669999999998 27.266079908960144 56.834925 56.834925 68.27409421670308 3.54778;58.0729 1.51564;40.0757 8.55785;105.112 0 0 Hill,1(0.5);Linear,1(0.5) 1.6291939270391391 3.2638449668884277 1.5375925302505493 1.7262524366378784 0.13340269914449965 1.6319224834442139 -22.624277599999992 84.24495759999999 -16.9931888 58.5845288 -37.78814199999998 151.457992 UP 1.0 0.0 0.0 GO:0051251 7 positive regulation of lymphocyte activation 82 87 5 5 4 5 4 4 92 83 2368 0.7714 0.41716 0.56817 4.6 29142;309607;63868;25599 vnn1;rt1-ce5;hspd1;cd74 VNN1_10157;RT1-CE5_32445;HSPD1_8849;CD74_8252 51.228175 44.63305 20.7328 32.315968320978726 60.84116996498567 32.22760799116447 32.231275 26.64045 16.8296 18.31578972132606 37.39993784275384 19.107430284649638 85.466625 83.62935 26.7838 57.18105629305189 99.6290666499932 51.54794017778054 20.7328;54.8206;34.4455;94.9138 16.8296;26.5902;26.6907;58.8146 26.7838;147.824;48.4857;118.773 3 1 3 29142;63868;25599 VNN1_10157;HSPD1_8849;CD74_8252 50.0307 34.4455 39.46997636850064 34.11163333333334 26.6907 21.954219296147446 64.68083333333333 48.4857 48.08549663800233 20.7328;34.4455;94.9138 16.8296;26.6907;58.8146 26.7838;48.4857;118.773 1 309607 RT1-CE5_32445 54.8206 54.8206 26.5902 26.5902 147.824 147.824 54.8206 26.5902 147.824 0 Exp 2,2(0.5);Linear,1(0.25);Poly 2,1(0.25) 2.1987063732296965 9.769550204277039 1.6557694673538208 4.608505725860596 1.4468770339148629 1.752637505531311 19.55852604544087 82.89782395455914 14.281801073100457 50.18074892689954 29.429189832809158 141.50406016719083 UP 0.75 0.25 0.0 GO:0001932 8 regulation of protein phosphorylation 371 395 17 17 10 16 10 10 86 385 2066 0.099573 0.9455 0.19519 2.53 24679;24484;24471;29455;299626;58868;25599;362485;114494;81633 prkar2b;igfbp3;hspb1;gdf15;gadd45b;fzd1;cd74;ccne2;ccna2;acta2 PRKAR2B_33052;IGFBP3_8881;HSPB1_8847;GDF15_33113;GADD45B_8679;FZD1_8671;CD74_8252;CCNE2_8227;CCNA2_8221;ACTA2_33040 61.64778 52.69915 21.3654 29.88310510003195 64.14644858372473 27.55690848445316 41.10756 37.2603 13.6792 18.292929735355866 43.03949164097578 17.39224559134457 104.10888 96.8074 26.3528 44.67110481564865 103.91514536012085 33.877281752897154 108.746;50.946;41.6322;21.3654;52.5718;25.231;94.9138;77.8893;52.8265;90.3558 59.3814;36.3081;30.9494;17.8875;37.1918;13.6792;58.8146;49.2672;37.3288;70.2676 147.467;85.0816;63.3196;26.3528;89.36;131.659;118.773;185.461;90.0448;103.57 6 4 6 24679;24471;29455;299626;58868;25599 PRKAR2B_33052;HSPB1_8847;GDF15_33113;GADD45B_8679;FZD1_8671;CD74_8252 57.41003333333333 47.102000000000004 36.46633596256508 36.31731666666666 34.0706 19.594904523412893 96.15523333333333 104.06649999999999 45.61077049705115 108.746;41.6322;21.3654;52.5718;25.231;94.9138 59.3814;30.9494;17.8875;37.1918;13.6792;58.8146 147.467;63.3196;26.3528;89.36;131.659;118.773 4 24484;362485;114494;81633 IGFBP3_8881;CCNE2_8227;CCNA2_8221;ACTA2_33040 68.0044 65.3579 19.310221722704252 48.292925 43.298 15.786952634243086 116.03935 96.8074 46.935946043198086 50.946;77.8893;52.8265;90.3558 36.3081;49.2672;37.3288;70.2676 85.0816;185.461;90.0448;103.57 0 Exp 2,1(0.1);Linear,5(0.5);Poly 2,3(0.3);Power,1(0.1) 1.8962472148100618 20.45966899394989 1.5124053955078125 5.015069484710693 1.0694795001754862 1.6392671465873718 43.12603956783822 80.16952043216178 29.76948468393545 52.44563531606457 76.4214423845411 131.7963176154589 UP 0.6 0.4 0.0 GO:0030162 7 regulation of proteolysis 214 230 7 7 5 7 5 5 91 225 2226 0.12064 0.94467 0.2725 2.17 84386;299270;25664;63868;64515 slpi;serpina6;pparg;hspd1;cdc20 SLPI_9890;SERPINA6_32325;PPARG_32510;HSPD1_8849;CDC20_8255 25664(0.0441) 63.66648 60.1903 34.4455 24.613459538878313 62.324835685935675 20.898210830219003 39.38626 37.8192 26.6907 9.190237817543132 39.202483241083236 7.936491165544562 156.95304000000002 92.543 48.4857 166.83172874676148 135.51191563031563 140.8452932910094 53.7429;68.3847;60.1903;34.4455;101.569 37.8192;36.9679;43.9036;26.6907;51.5499 92.543;89.5095;101.057;48.4857;453.17 3 2 3 299270;25664;63868 SERPINA6_32325;PPARG_32510;HSPD1_8849 54.34016666666667 60.1903 17.7097535040252 35.85406666666666 36.9679 8.660337760349384 79.68406666666668 89.5095 27.628603856571026 68.3847;60.1903;34.4455 36.9679;43.9036;26.6907 89.5095;101.057;48.4857 2 84386;64515 SLPI_9890;CDC20_8255 77.65595 77.65595 33.81815962770593 44.68455 44.68455 9.709071080438125 272.8565 272.8565 255.00179717896117 53.7429;101.569 37.8192;51.5499 92.543;453.17 0 Exp 2,3(0.6);Linear,1(0.2);Poly 2,1(0.2) 1.6535862141804831 8.292219042778015 1.5239794254302979 1.8690931797027588 0.14336901850129022 1.6557694673538208 42.091831473373965 85.24112852662603 31.330661376149024 47.441858623850976 10.718582177626729 303.18749782237325 UP 0.6 0.4 0.0 GO:0019438 5 aromatic compound biosynthetic process 165 183 8 8 6 8 6 6 90 177 2274 0.45752 0.70008 0.84235 3.28 78968;298490;313245;364975;114027;65155 srebf1;ppcs;polr1e;gcdh;dao;alas1 SREBF1_32750;PPCS_9540;POLR1E_9523;GCDH_8693;DAO_8437;ALAS1_8018 29.918666666666667 21.5432 6.1336 24.729980577482596 29.978097146292583 18.555845044794598 20.23273 15.972100000000001 2.43617 16.974816496348936 21.359546408817636 13.825895064342308 56.762750000000004 33.97165 16.2027 55.25291832541518 50.3303878757515 37.510967299214414 41.2009;15.1091;73.982;15.9021;6.1336;27.1843 31.4864;7.94061;47.589;10.4227;2.43617;21.5215 60.0774;30.6311;165.722;31.2818;16.2027;36.6615 6 0 6 78968;298490;313245;364975;114027;65155 SREBF1_32750;PPCS_9540;POLR1E_9523;GCDH_8693;DAO_8437;ALAS1_8018 29.918666666666667 21.5432 24.729980577482596 20.23273 15.972100000000001 16.974816496348936 56.762750000000004 33.97165 55.25291832541518 41.2009;15.1091;73.982;15.9021;6.1336;27.1843 31.4864;7.94061;47.589;10.4227;2.43617;21.5215 60.0774;30.6311;165.722;31.2818;16.2027;36.6615 0 0 Exp 2,1(0.17);Hill,2(0.34);Linear,2(0.34);Poly 2,1(0.17) 1.785547497233333 10.781362771987915 1.5184675455093384 2.0627336502075195 0.21776724960295554 1.8705788850784302 10.13056097050152 49.706772362831806 6.650047961478418 33.81541203852157 12.55120747899921 100.97429252100079 UP 1.0 0.0 0.0 GO:0071396 6 cellular response to lipid 195 209 11 11 10 11 10 10 86 199 2252 0.84088 0.25929 0.44509 4.78 286954;78968;24950;25664;24614;24484;24471;58868;25315;114494 ugt2b1;srebf1;srd5a1;pparg;orm1;igfbp3;hspb1;fzd1;ephx1;ccna2 UGT2B10_33303,UGT2B1_33224;SREBF1_32750;SRD5A1_32503;PPARG_32510;ORM1_9400;IGFBP3_8881;HSPB1_8847;FZD1_8671;EPHX1_8567;CCNA2_8221 25664(0.0441) 37.204505 37.60715 12.54415 14.87048454759462 37.97117462303006 15.166658199145989 26.9805745 28.55365 7.348245 11.297871013747692 27.778812666870895 11.426192296630651 67.64465499999999 61.698499999999996 25.495849999999997 33.87210959821641 66.59707487491066 32.902765478761 12.54415;41.2009;29.2087;60.1903;24.2519;50.946;41.6322;25.231;34.0134;52.8265 7.348245;31.4864;22.9308;43.9036;19.7133;36.3081;30.9494;13.6792;26.1579;37.3288 25.495849999999997;60.0774;39.9852;101.057;31.358;85.0816;63.3196;131.659;48.3681;90.0448 8 3 7 286954;78968;25664;24614;24471;58868;25315 UGT2B10_33303,UGT2B1_33224;SREBF1_32750;PPARG_32510;ORM1_9400;HSPB1_8847;FZD1_8671;EPHX1_8567 34.151978571428565 34.0134 15.428048389914643 24.748292142857142 26.1579 12.270603332644193 65.90499285714286 60.0774 38.15283805357111 12.54415;41.2009;60.1903;24.2519;41.6322;25.231;34.0134 7.348245;31.4864;43.9036;19.7133;30.9494;13.6792;26.1579 25.495849999999997;60.0774;101.057;31.358;63.3196;131.659;48.3681 3 24950;24484;114494 SRD5A1_32503;IGFBP3_8881;CCNA2_8221 44.32706666666667 50.946 13.126607637288968 32.189233333333334 36.3081 8.034263996367907 71.70386666666667 85.0816 27.581038774733106 29.2087;50.946;52.8265 22.9308;36.3081;37.3288 39.9852;85.0816;90.0448 0 Exp 2,3(0.28);Exp 4,1(0.1);Linear,5(0.46);Poly 2,2(0.19) 1.9193757335964543 21.760981798171997 1.5124053955078125 3.5849626064300537 0.5818414545021525 1.8468482494354248 27.987683188175446 46.42132681182455 19.978081497609313 33.98306750239069 46.650503964897936 88.63880603510206 UP 0.7 0.3 0.0 GO:0070989 4 oxidative demethylation 3 4 1 1 1 1 1 1 95 3 2448 0.99197 0.14253 0.14253 25.0 266682 cyp3a2 CYP3A2_32374 23.2485 23.2485 23.2485 23.2485 18.6955 18.6955 18.6955 18.6955 30.5145 30.5145 30.5145 30.514500000000005 0.0 23.2485 0.0 23.2485 23.2485 18.6955 30.5145 1 0 1 266682 CYP3A2_32374 23.2485 23.2485 18.6955 18.6955 30.5145 30.5145 23.2485 18.6955 30.5145 0 0 Linear,1(1) 3.7662253379821777 3.7662253379821777 3.7662253379821777 3.7662253379821777 0.0 3.7662253379821777 23.2485 23.2485 18.6955 18.6955 30.5145 30.5145 UP 1.0 0.0 0.0 GO:0006629 4 lipid metabolic process 289 320 46 45 40 46 39 39 57 281 2170 1.0 1.36E-12 1.36E-12 12.19 360268;64305;78968;24950;299270;24679;25664;296371;65035;364975;65030;25315;171142;291075;29740;64526;117543;25427;50549;266682;65210;25086;24303;499353;171521;29277;24894;311849;25413;25599;25649;502970;24763;50681;681337;314304;192272;50559;170465 sult1e1;sult1b1;srebf1;srd5a1;serpina6;prkar2b;pparg;pltp;nr1i3;gcdh;ephx2;ephx1;ehhadh;eci2;eci1;ech1;decr1;cyp51;cyp4a1;cyp3a2;cyp2j4;cyp2e1;cyp2d3;cyp2c24;cyp2c13;cyp2c11;cyp2a1;crat;cpt2;cd74;apoa2;angptl3;acsm3;acox1;acot4;acot3;acot2;acot1;acaa2 SULT1E1_32446;SULT1B1_32942;SREBF1_32750;SRD5A1_32503;SERPINA6_32325;PRKAR2B_33052;PPARG_32510;PLTP_32412;NR1I3_32602;GCDH_8693;EPHX2_33282;EPHX1_8567;EHHADH_8534;ECI2_8521;ECI1_8520;ECH1_8516;DECR1_8458;CYP51_8429;CYP4A1_33111;CYP3A2_32374;CYP2J4_32580;CYP2E1_8421;CYP2D3_8420;CYP2C24_32875;CYP2C13_8419;CYP2C11_32593;CYP2A1_32717;CRAT_8375;CPT2_8374;CD74_8252;APOA2_33095;ANGPTL3_8045;ACSM3_7976;ACOX1_7973;ACOT4_7971;ACOT3_7970;ACOT2_7969;ACOT1_7968;ACAA2_7955 25664(0.0441) 36.65956025641026 23.8014 3.54778 29.931845147978343 38.9827253922701 30.617537489812772 24.416663589743592 19.0993 1.51564 18.40037164333122 25.554700474713076 18.88989846213275 54.647014102564114 36.8422 8.55785 40.7023306241743 57.173666323669174 38.01099885316681 15.0 21.6199 31.0 60.1903 59.2729;15.4629;41.2009;29.2087;68.3847;108.746;60.1903;87.0256;22.095;15.9021;6.44145;34.0134;7.29984;8.72912;11.7653;9.87438;21.6199;75.1522;23.208;23.2485;16.3155;7.89174;12.8059;58.9435;104.635;54.426;9.37187;8.98517;31.2175;94.9138;3.54778;58.0729;52.2057;23.8014;12.3157;30.8838;13.6362;28.5134;78.3988 45.3114;7.69418;31.4864;22.9308;36.9679;59.3814;43.9036;56.6266;12.9529;10.4227;2.66377;26.1579;5.26587;5.10151;8.40998;6.59127;17.4928;48.098;18.863;18.6955;8.2378;4.16797;8.8664;48.1505;49.2461;43.9518;4.95906;1.97988;24.8356;58.8146;1.51564;40.0757;42.2655;19.0993;6.70485;24.6874;11.3249;24.741;43.6084 91.5578;35.0879;60.0774;39.9852;89.5095;147.467;101.057;104.563;55.8619;31.2818;17.3473;48.3681;11.8779;17.7951;18.8402;19.44;28.0829;171.379;29.9853;30.5145;36.8422;15.8079;22.6004;80.4167;108.327;74.8861;19.1079;31.3726;42.0237;118.773;8.55785;105.112;71.1126;31.3543;24.3993;41.2585;16.9658;33.4642;98.7727 36 3 36 360268;64305;78968;299270;24679;25664;296371;65035;364975;65030;25315;171142;291075;29740;64526;117543;50549;266682;65210;25086;24303;499353;171521;29277;24894;311849;25413;25599;25649;502970;24763;50681;681337;314304;192272;50559 SULT1E1_32446;SULT1B1_32942;SREBF1_32750;SERPINA6_32325;PRKAR2B_33052;PPARG_32510;PLTP_32412;NR1I3_32602;GCDH_8693;EPHX2_33282;EPHX1_8567;EHHADH_8534;ECI2_8521;ECI1_8520;ECH1_8516;DECR1_8458;CYP4A1_33111;CYP3A2_32374;CYP2J4_32580;CYP2E1_8421;CYP2D3_8420;CYP2C24_32875;CYP2C13_8419;CYP2C11_32593;CYP2A1_32717;CRAT_8375;CPT2_8374;CD74_8252;APOA2_33095;ANGPTL3_8045;ACSM3_7976;ACOX1_7973;ACOT4_7971;ACOT3_7970;ACOT2_7969;ACOT1_7968 34.63786527777778 23.22825 29.577153181900048 23.26701888888889 18.779249999999998 18.428923613465983 50.58601805555556 34.27605 36.47767497786273 59.2729;15.4629;41.2009;68.3847;108.746;60.1903;87.0256;22.095;15.9021;6.44145;34.0134;7.29984;8.72912;11.7653;9.87438;21.6199;23.208;23.2485;16.3155;7.89174;12.8059;58.9435;104.635;54.426;9.37187;8.98517;31.2175;94.9138;3.54778;58.0729;52.2057;23.8014;12.3157;30.8838;13.6362;28.5134 45.3114;7.69418;31.4864;36.9679;59.3814;43.9036;56.6266;12.9529;10.4227;2.66377;26.1579;5.26587;5.10151;8.40998;6.59127;17.4928;18.863;18.6955;8.2378;4.16797;8.8664;48.1505;49.2461;43.9518;4.95906;1.97988;24.8356;58.8146;1.51564;40.0757;42.2655;19.0993;6.70485;24.6874;11.3249;24.741 91.5578;35.0879;60.0774;89.5095;147.467;101.057;104.563;55.8619;31.2818;17.3473;48.3681;11.8779;17.7951;18.8402;19.44;28.0829;29.9853;30.5145;36.8422;15.8079;22.6004;80.4167;108.327;74.8861;19.1079;31.3726;42.0237;118.773;8.55785;105.112;71.1126;31.3543;24.3993;41.2585;16.9658;33.4642 3 24950;25427;170465 SRD5A1_32503;CYP51_8429;ACAA2_7955 60.91989999999999 75.1522 27.510638977857276 38.2124 43.6084 13.423285773609972 103.37896666666666 98.7727 65.81789983783543 29.2087;75.1522;78.3988 22.9308;48.098;43.6084 39.9852;171.379;98.7727 0 Exp 2,10(0.26);Exp 4,5(0.13);Hill,6(0.16);Linear,8(0.21);Poly 2,8(0.21);Power,2(0.06) 2.2811735777216278 134.97108161449432 1.5084086656570435 50.888092041015625 7.832501736040336 1.912555456161499 27.26541529350022 46.053705219320285 18.64168521021834 30.191641969268836 41.872539548074045 67.42148865705416 UP 0.9230769230769231 0.07692307692307693 0.0 GO:0042760 7 very long-chain fatty acid catabolic process 2 2 1 1 1 1 1 1 95 1 2450 0.99859 0.073976 0.073976 50.0 192272 acot2 ACOT2_7969 13.6362 13.6362 13.6362 13.6362 11.3249 11.3249 11.3249 11.3249 16.9658 16.9658 16.9658 16.9658 0.0 13.6362 0.0 13.6362 13.6362 11.3249 16.9658 1 0 1 192272 ACOT2_7969 13.6362 13.6362 11.3249 11.3249 16.9658 16.9658 13.6362 11.3249 16.9658 0 0 Linear,1(1) 4.473705768585205 4.473705768585205 4.473705768585205 4.473705768585205 0.0 4.473705768585205 13.6362 13.6362 11.3249 11.3249 16.9658 16.9658 UP 1.0 0.0 0.0 GO:0006357 8 regulation of transcription by RNA polymerase II 343 364 11 11 7 11 7 7 89 357 2094 0.025366 0.98954 0.051823 1.92 360243;78968;25664;54133;65035;259241;306575 top2a;srebf1;pparg;pdlim1;nr1i3;nr1d2;ckap2 TOP2A_10059;SREBF1_32750;PPARG_32510;PDLIM1_9452;NR1I3_32602;NR1D2_9358;CKAP2_8324 25664(0.0441) 58.3993 60.1903 22.095 23.765925962113627 55.54599489538203 20.79773282364826 34.29805714285714 42.5557 12.9529 13.59171443476469 35.25248667173159 13.200625668397338 112.53004285714285 102.838 55.8619 54.343413472957856 106.41791057678489 49.0171841082337 54.9577;41.2009;60.1903;67.1147;22.095;99.0234;64.2131 18.8326;31.4864;43.9036;47.2419;12.9529;42.5557;43.1133 218.525;60.0774;101.057;123.914;55.8619;102.838;125.437 5 2 5 78968;25664;54133;65035;259241 SREBF1_32750;PPARG_32510;PDLIM1_9452;NR1I3_32602;NR1D2_9358 57.92486 60.1903 28.905644230201826 35.628099999999996 42.5557 13.988158084429857 88.74965999999999 101.057 29.53889808706481 41.2009;60.1903;67.1147;22.095;99.0234 31.4864;43.9036;47.2419;12.9529;42.5557 60.0774;101.057;123.914;55.8619;102.838 2 360243;306575 TOP2A_10059;CKAP2_8324 59.5854 59.5854 6.544556102593976 30.97295 30.97295 17.169047621956203 171.981 171.981 65.8231560470934 54.9577;64.2131 18.8326;43.1133 218.525;125.437 0 Exp 2,4(0.58);Linear,1(0.15);Poly 2,1(0.15);Power,1(0.15) 1.9993782515120913 14.304324388504028 1.5239794254302979 2.7270524501800537 0.47010470268059357 1.912555456161499 40.793255663580695 76.00534433641931 24.22917418294678 44.366940102767515 72.2718787728779 152.7882069414078 UP 0.7142857142857143 0.2857142857142857 0.0 GO:0034698 5 response to gonadotropin 33 36 4 4 4 4 4 4 92 32 2419 0.98978 0.044365 0.044365 11.11 24950;114494;25612;65155 srd5a1;ccna2;asns;alas1 SRD5A1_32503;CCNA2_8221;ASNS_8091;ALAS1_8018 34.3522 28.698999999999998 27.1843 12.343898351817382 34.32578962140992 12.376863314614932 26.239625 23.0541 21.5215 7.428684282955705 26.174186194516974 7.481478406851966 50.659724999999995 38.32335 35.9474 26.31560010581494 50.735131546997394 26.291293368751344 0.5 27.686799999999998 2.5 41.0176 29.2087;52.8265;28.1893;27.1843 22.9308;37.3288;23.1774;21.5215 39.9852;90.0448;35.9474;36.6615 2 2 2 25612;65155 ASNS_8091;ALAS1_8018 27.686799999999998 27.686799999999998 0.7106423150928148 22.349449999999997 22.349449999999997 1.1708981189668581 36.30445 36.30445 0.5049449524451981 28.1893;27.1843 23.1774;21.5215 35.9474;36.6615 2 24950;114494 SRD5A1_32503;CCNA2_8221 41.0176 41.0176 16.700306536707636 30.129800000000003 30.129800000000003 10.180923435523901 65.015 65.015 35.39748262348606 29.2087;52.8265 22.9308;37.3288 39.9852;90.0448 0 Exp 2,1(0.25);Linear,3(0.75) 2.284081417278076 9.377119541168213 1.8392632007598877 3.2609751224517822 0.6455404464400674 2.1384406089782715 22.255179615218964 46.44922038478104 18.959514402703395 33.51973559729661 24.870436896301374 76.44901310369863 CONFLICT 0.5 0.5 0.0 GO:0006457 3 protein folding 33 38 3 3 3 3 3 3 93 35 2416 0.94747 0.17049 0.17049 7.89 63868;24471;25599 hspd1;hspb1;cd74 HSPD1_8849;HSPB1_8847;CD74_8252 56.99716666666666 41.6322 34.4455 33.03279395878185 61.82378295283947 34.4601695376049 38.81823333333333 30.9494 26.6907 17.447783278208533 41.3670039498887 18.192729745058582 76.85943333333334 63.3196 48.4857 37.04823140641577 82.24370376870115 38.4901448452484 0.5 38.03885 34.4455;41.6322;94.9138 26.6907;30.9494;58.8146 48.4857;63.3196;118.773 3 0 3 63868;24471;25599 HSPD1_8849;HSPB1_8847;CD74_8252 56.99716666666666 41.6322 33.03279395878185 38.81823333333333 30.9494 17.447783278208533 76.85943333333334 63.3196 37.04823140641577 34.4455;41.6322;94.9138 26.6907;30.9494;58.8146 48.4857;63.3196;118.773 0 0 Exp 2,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 1.7178371858221524 5.160351991653442 1.6557694673538208 1.8468482494354248 0.10975659191173062 1.6577342748641968 19.61704139765792 94.3772919356754 19.074207883358874 58.56225878330779 34.93541283736567 118.78345382930098 UP 1.0 0.0 0.0 GO:0045923 7 positive regulation of fatty acid metabolic process 25 26 3 3 2 3 2 2 94 24 2427 0.92789 0.25657 0.25657 7.69 25664;25599 pparg;cd74 PPARG_32510;CD74_8252 25664(0.0441) 77.55205 77.55205 60.1903 24.55322231653108 77.05821210678558 24.54328776662683 51.3591 51.3591 43.9036 10.543669214272617 51.147035639387724 10.53940310994491 109.91499999999999 109.91499999999999 101.057 12.527103735500948 109.66304290707485 12.522035108026467 0.5 77.55205 60.1903;94.9138 43.9036;58.8146 101.057;118.773 2 0 2 25664;25599 PPARG_32510;CD74_8252 77.55205 77.55205 24.55322231653108 51.3591 51.3591 10.543669214272617 109.91499999999999 109.91499999999999 12.527103735500948 60.1903;94.9138 43.9036;58.8146 101.057;118.773 0 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.589450511253386 3.1817137002944946 1.5239794254302979 1.6577342748641968 0.09457896105129558 1.5908568501472473 43.52302 111.58107999999999 36.74632 65.97188 92.55332 127.27667999999998 UP 1.0 0.0 0.0 GO:0007052 7 mitotic spindle organization 19 19 2 2 2 2 2 2 94 17 2434 0.96756 0.15902 0.15902 10.53 304951;64515 nuf2;cdc20 NUF2_33136;CDC20_8255 50.784500000000286 50.784500000000286 5.73955E-13 71.82012865833605 63.06563581715739 69.68843725167771 25.77495000000029 25.77495000000029 5.73955E-13 36.451283859487994 32.00806564809039 35.36937423308531 226.5850000000003 226.5850000000003 5.73957E-13 320.43958003030735 281.37969442705094 310.92862102947686 0.0 5.73955E-13 0.5 50.784500000000286 5.73955E-13;101.569 5.73955E-13;51.5499 5.73957E-13;453.17 0 2 0 2 304951;64515 NUF2_33136;CDC20_8255 50.784500000000286 50.784500000000286 71.82012865833605 25.77495000000029 25.77495000000029 36.451283859487994 226.5850000000003 226.5850000000003 320.43958003030735 5.73955E-13;101.569 5.73955E-13;51.5499 5.73957E-13;453.17 0 Exp 2,1(0.5);Hill,1(0.5) 1.680680639606233 3.3763372898101807 1.5293418169021606 1.84699547290802 0.22461505423044203 1.6881686449050903 -48.75311999999916 150.32211999999976 -24.743951999999148 76.29385199999973 -217.52159999999915 670.6915999999998 DOWN 0.0 1.0 0.0 GO:0042592 4 homeostatic process 357 379 14 14 10 14 10 10 86 369 2082 0.13216 0.92465 0.24351 2.64 25664;65035;259241;65030;362485;25649;155423;502970;50681;114628 pparg;nr1i3;nr1d2;ephx2;ccne2;apoa2;anxa7;angptl3;acox1;abcg5 PPARG_32510;NR1I3_32602;NR1D2_9358;EPHX2_33282;CCNE2_8227;APOA2_33095;ANXA7_8051;ANGPTL3_8045;ACOX1_7973;ABCG5_7947 25664(0.0441) 44.894102999999994 45.5924 3.54778 31.82053932807273 41.024093782462685 28.96897662246086 27.962231000000003 32.14275 1.51564 18.14371192163919 26.49984202011499 17.8965096151107 78.54612499999999 78.45945 8.55785 55.57730828941118 71.80006646827142 47.48637835832648 60.1903;22.095;99.0234;6.44145;77.8893;3.54778;64.7676;58.0729;23.8014;33.1119 43.9036;12.9529;42.5557;2.66377;49.2672;1.51564;43.3787;40.0757;19.0993;24.2098 101.057;55.8619;102.838;17.3473;185.461;8.55785;127.439;105.112;31.3543;50.4329 8 2 8 25664;65035;259241;65030;25649;155423;502970;50681 PPARG_32510;NR1I3_32602;NR1D2_9358;EPHX2_33282;APOA2_33095;ANXA7_8051;ANGPTL3_8045;ACOX1_7973 42.24247875 40.93715 33.443274545451885 25.76816375 29.5875 18.73215207443375 68.69591874999999 78.45945 45.984746459730225 60.1903;22.095;99.0234;6.44145;3.54778;64.7676;58.0729;23.8014 43.9036;12.9529;42.5557;2.66377;1.51564;43.3787;40.0757;19.0993 101.057;55.8619;102.838;17.3473;8.55785;127.439;105.112;31.3543 2 362485;114628 CCNE2_8227;ABCG5_7947 55.500600000000006 55.500600000000006 31.662403183902494 36.7385 36.7385 17.718257458903796 117.94695 117.94695 95.47928516073527 77.8893;33.1119 49.2672;24.2098 185.461;50.4329 0 Exp 2,2(0.2);Exp 4,1(0.1);Hill,1(0.1);Linear,4(0.4);Poly 2,1(0.1);Power,1(0.1) 1.8756469948174062 19.22237265110016 1.5239794254302979 2.7270524501800537 0.46456420284129435 1.6580174565315247 25.17152839227196 64.61667760772806 16.716641843063258 39.20782015693674 44.09895243848443 112.99329756151558 UP 0.8 0.2 0.0 GO:0035359 7 negative regulation of peroxisome proliferator activated receptor signaling pathway 2 2 1 1 1 1 1 1 95 1 2450 0.99859 0.073976 0.073976 50.0 65210 cyp2j4 CYP2J4_32580 16.3155 16.3155 16.3155 16.3155 8.2378 8.2378 8.2378 8.2378 36.8422 36.8422 36.8422 36.8422 0.0 16.3155 0.0 16.3155 16.3155 8.2378 36.8422 1 0 1 65210 CYP2J4_32580 16.3155 16.3155 8.2378 8.2378 36.8422 36.8422 16.3155 8.2378 36.8422 0 0 Exp 4,1(1) 1.940477728843689 1.940477728843689 1.940477728843689 1.940477728843689 0.0 1.940477728843689 16.3155 16.3155 8.2378 8.2378 36.8422 36.8422 UP 1.0 0.0 0.0 GO:0051130 6 positive regulation of cellular component organization 262 280 8 8 7 8 7 7 89 273 2178 0.15401 0.91797 0.31664 2.5 78968;25664;24484;24471;29455;58868;64515 srebf1;pparg;igfbp3;hspb1;gdf15;fzd1;cdc20 SREBF1_32750;PPARG_32510;IGFBP3_8881;HSPB1_8847;GDF15_33113;FZD1_8671;CDC20_8255 25664(0.0441) 48.876400000000004 41.6322 21.3654 26.882923539488758 51.846106043502914 23.816418545747222 32.25201428571429 31.4864 13.6792 13.405169055185208 34.75648417865059 11.886920351225767 131.53105714285715 85.0816 26.3528 145.69302199001453 130.3684267511984 136.18725056083449 41.2009;60.1903;50.946;41.6322;21.3654;25.231;101.569 31.4864;43.9036;36.3081;30.9494;17.8875;13.6792;51.5499 60.0774;101.057;85.0816;63.3196;26.3528;131.659;453.17 5 2 5 78968;25664;24471;29455;58868 SREBF1_32750;PPARG_32510;HSPB1_8847;GDF15_33113;FZD1_8671 37.92396000000001 41.2009 15.4561995611146 27.581219999999995 30.9494 12.044184527480471 76.49316 63.3196 40.631661604074225 41.2009;60.1903;41.6322;21.3654;25.231 31.4864;43.9036;30.9494;17.8875;13.6792 60.0774;101.057;63.3196;26.3528;131.659 2 24484;64515 IGFBP3_8881;CDC20_8255 76.2575 76.2575 35.79586658400661 43.929 43.929 10.77758013748912 269.1258 269.1258 260.27780371610635 50.946;101.569 36.3081;51.5499 85.0816;453.17 0 Exp 2,4(0.58);Linear,2(0.29);Poly 2,1(0.15) 1.9533913891790464 15.078203916549683 1.5124053955078125 5.015069484710693 1.2721488553558264 1.7380040884017944 28.96125154404156 68.79154845595845 22.32132607693063 42.18270249449793 23.600156038805068 239.46195824690923 UP 0.7142857142857143 0.2857142857142857 0.0 GO:0051172 6 negative regulation of nitrogen compound metabolic process 471 499 17 16 13 17 12 12 84 487 1964 0.043978 0.9772 0.087442 2.4 78968;84386;299270;24679;25664;65035;259241;24484;24471;299626;58868;25427 srebf1;slpi;serpina6;prkar2b;pparg;nr1i3;nr1d2;igfbp3;hspb1;gadd45b;fzd1;cyp51 SREBF1_32750;SLPI_9890;SERPINA6_32325;PRKAR2B_33052;PPARG_32510;NR1I3_32602;NR1D2_9358;IGFBP3_8881;HSPB1_8847;GADD45B_8679;FZD1_8671;CYP51_8429 25664(0.0441) 58.24303333333333 53.15735 22.095 26.413912741491952 53.91977672486341 22.017771871093885 35.94113333333333 37.07985 12.9529 13.0714250814747 34.61467178103418 11.397606312673991 99.17941666666667 91.02625 55.8619 35.342897607525884 89.9515525560706 27.50956305357176 41.2009;53.7429;68.3847;108.746;60.1903;22.095;99.0234;50.946;41.6322;52.5718;25.231;75.1522 31.4864;37.8192;36.9679;59.3814;43.9036;12.9529;42.5557;36.3081;30.9494;37.1918;13.6792;48.098 60.0774;92.543;89.5095;147.467;101.057;55.8619;102.838;85.0816;63.3196;89.36;131.659;171.379 9 3 9 78968;299270;24679;25664;65035;259241;24471;299626;58868 SREBF1_32750;SERPINA6_32325;PRKAR2B_33052;PPARG_32510;NR1I3_32602;NR1D2_9358;HSPB1_8847;GADD45B_8679;FZD1_8671 57.67503333333333 52.5718 30.233096972978142 34.34092222222222 36.9679 14.598743112745861 93.46104444444444 89.5095 31.603908385598103 41.2009;68.3847;108.746;60.1903;22.095;99.0234;41.6322;52.5718;25.231 31.4864;36.9679;59.3814;43.9036;12.9529;42.5557;30.9494;37.1918;13.6792 60.0774;89.5095;147.467;101.057;55.8619;102.838;63.3196;89.36;131.659 3 84386;24484;25427 SLPI_9890;IGFBP3_8881;CYP51_8429 59.94703333333333 53.7429 13.242110195257169 40.74176666666667 37.8192 6.415331826439964 116.33453333333334 92.543 47.815667991290624 53.7429;50.946;75.1522 37.8192;36.3081;48.098 92.543;85.0816;171.379 0 Exp 2,2(0.17);Linear,5(0.42);Poly 2,3(0.25);Power,2(0.17) 1.7854292455780183 21.715755105018616 1.5124053955078125 2.7270524501800537 0.33560921407701355 1.7260196208953857 43.29795529431469 73.18811137235197 28.545278359641514 43.33698830702515 79.18228984797312 119.17654348536018 UP 0.75 0.25 0.0 GO:0043065 8 positive regulation of apoptotic process 196 210 7 7 5 7 5 5 91 205 2246 0.18218 0.90946 0.34498 2.38 360243;25664;24484;63868;299626 top2a;pparg;igfbp3;hspd1;gadd45b TOP2A_10059;PPARG_32510;IGFBP3_8881;HSPD1_8849;GADD45B_8679 25664(0.0441) 50.62226 52.5718 34.4455 9.69454108418754 51.60012010037796 9.454079541091481 32.58536 36.3081 18.8326 9.836997298617087 34.420737911270834 9.442548555119469 108.50186000000001 89.36 48.4857 64.57045787307071 103.33769081417684 56.06541314191457 54.9577;60.1903;50.946;34.4455;52.5718 18.8326;43.9036;36.3081;26.6907;37.1918 218.525;101.057;85.0816;48.4857;89.36 3 2 3 25664;63868;299626 PPARG_32510;HSPD1_8849;GADD45B_8679 49.0692 52.5718 13.224970201478696 35.9287 37.1918 8.675687166443922 79.63423333333333 89.36 27.6021430121528 60.1903;34.4455;52.5718 43.9036;26.6907;37.1918 101.057;48.4857;89.36 2 360243;24484 TOP2A_10059;IGFBP3_8881 52.95185 52.95185 2.8367002740860277 27.57035 27.57035 12.357044554625517 151.8033 151.8033 94.35873304458893 54.9577;50.946 18.8326;36.3081 218.525;85.0816 0 Exp 2,3(0.6);Linear,2(0.4) 1.65187745557259 8.276661157608032 1.5239794254302979 1.8061060905456543 0.11972215134872659 1.6557694673538208 42.124620073036134 59.119899926963875 23.96285169555767 41.20786830444233 51.90335820815074 165.10036179184928 UP 0.6 0.4 0.0 GO:0032268 6 regulation of cellular protein metabolic process 600 637 23 23 16 22 16 16 80 621 1830 0.031782 0.98292 0.054996 2.51 78968;84386;299270;24679;25664;24484;63868;24471;29455;299626;58868;64515;25599;362485;114494;81633 srebf1;slpi;serpina6;prkar2b;pparg;igfbp3;hspd1;hspb1;gdf15;gadd45b;fzd1;cdc20;cd74;ccne2;ccna2;acta2 SREBF1_32750;SLPI_9890;SERPINA6_32325;PRKAR2B_33052;PPARG_32510;IGFBP3_8881;HSPD1_8849;HSPB1_8847;GDF15_33113;GADD45B_8679;FZD1_8671;CDC20_8255;CD74_8252;CCNE2_8227;CCNA2_8221;ACTA2_33040 25664(0.0441) 61.00069375 53.2847 21.3654 26.94691128374378 61.269109946310714 23.78586845533918 39.96833125 37.2603 13.6792 15.135254657420152 40.44331113787322 13.50679463257109 117.87071250000001 91.29390000000001 26.3528 97.3522676458977 112.20258543386457 88.066456315414 41.2009;53.7429;68.3847;108.746;60.1903;50.946;34.4455;41.6322;21.3654;52.5718;25.231;101.569;94.9138;77.8893;52.8265;90.3558 31.4864;37.8192;36.9679;59.3814;43.9036;36.3081;26.6907;30.9494;17.8875;37.1918;13.6792;51.5499;58.8146;49.2672;37.3288;70.2676 60.0774;92.543;89.5095;147.467;101.057;85.0816;48.4857;63.3196;26.3528;89.36;131.659;453.17;118.773;185.461;90.0448;103.57 10 6 10 78968;299270;24679;25664;63868;24471;29455;299626;58868;25599 SREBF1_32750;SERPINA6_32325;PRKAR2B_33052;PPARG_32510;HSPD1_8849;HSPB1_8847;GDF15_33113;GADD45B_8679;FZD1_8671;CD74_8252 54.86816 47.102000000000004 28.872586148386493 35.69525 34.22715 15.238533776088827 87.6061 89.43475000000001 38.460690860785235 41.2009;68.3847;108.746;60.1903;34.4455;41.6322;21.3654;52.5718;25.231;94.9138 31.4864;36.9679;59.3814;43.9036;26.6907;30.9494;17.8875;37.1918;13.6792;58.8146 60.0774;89.5095;147.467;101.057;48.4857;63.3196;26.3528;89.36;131.659;118.773 6 84386;24484;64515;362485;114494;81633 SLPI_9890;IGFBP3_8881;CDC20_8255;CCNE2_8227;CCNA2_8221;ACTA2_33040 71.22158333333333 65.8161 21.847311654976384 47.090133333333334 43.5432 13.109616128577796 168.31173333333334 98.0565 144.51552883311425 53.7429;50.946;101.569;77.8893;52.8265;90.3558 37.8192;36.3081;51.5499;49.2672;37.3288;70.2676 92.543;85.0816;453.17;185.461;90.0448;103.57 0 Exp 2,5(0.32);Linear,6(0.38);Poly 2,4(0.25);Power,1(0.07) 1.8177895948454597 30.664443492889404 1.5124053955078125 5.015069484710693 0.8515434469542639 1.6567518711090088 47.79670722096556 74.20468027903446 32.55205646786413 47.38460603213588 70.16810135351011 165.57332364648988 UP 0.625 0.375 0.0 GO:0034614 6 cellular response to reactive oxygen species 66 70 4 4 2 4 2 2 94 68 2383 0.50366 0.7501 1.0 2.86 24471;114494 hspb1;ccna2 HSPB1_8847;CCNA2_8221 47.22935 47.22935 41.6322 7.915565440636575 46.10478981356109 7.754154049227537 34.1391 34.1391 30.9494 4.510916999901443 33.49823641287366 4.418931986961385 76.6822 76.6822 63.3196 18.89757014856674 73.99743222580983 18.512217628294447 41.6322;52.8265 30.9494;37.3288 63.3196;90.0448 1 1 1 24471 HSPB1_8847 41.6322 41.6322 30.9494 30.9494 63.3196 63.3196 41.6322 30.9494 63.3196 1 114494 CCNA2_8221 52.8265 52.8265 37.3288 37.3288 90.0448 90.0448 52.8265 37.3288 90.0448 0 Linear,2(1) 2.072444594657249 4.172446250915527 1.8468482494354248 2.3255980014801025 0.3385271961621698 2.0862231254577637 36.25893599999999 58.199764 27.887287999999998 40.390912 50.491504000000006 102.87289599999998 CONFLICT 0.5 0.5 0.0 GO:0044249 4 cellular biosynthetic process 372 415 22 21 17 22 16 16 80 399 2052 0.6061 0.50416 0.88827 3.86 78968;24950;293820;298490;313245;296371;362094;364975;114027;50549;29277;25599;25612;25649;65155;24763 srebf1;srd5a1;psat1;ppcs;polr1e;pltp;mrps2;gcdh;dao;cyp4a1;cyp2c11;cd74;asns;apoa2;alas1;acsm3 SREBF1_32750;SRD5A1_32503;PSAT1_9583;PPCS_9540;POLR1E_9523;PLTP_32412;MRPS2_9250;GCDH_8693;DAO_8437;CYP4A1_33111;CYP2C11_32593;CD74_8252;ASNS_8091;APOA2_33095;ALAS1_8018;ACSM3_7976 40.1177675 28.698999999999998 3.54778 28.10526716961728 46.557004390639456 29.229047480249275 28.487713749999998 23.0541 1.51564 18.638070681233035 32.887156766632465 19.046344650527196 60.682959375 38.32335 8.55785 43.869288529498704 67.10737994032462 39.884945063402164 41.2009;29.2087;26.3316;15.1091;73.982;87.0256;63.3158;15.9021;6.1336;23.208;54.426;94.9138;28.1893;3.54778;27.1843;52.2057 31.4864;22.9308;20.9188;7.94061;47.589;56.6266;45.3429;10.4227;2.43617;18.863;43.9518;58.8146;23.1774;1.51564;21.5215;42.2655 60.0774;39.9852;35.2954;30.6311;165.722;104.563;111.245;31.2818;16.2027;29.9853;74.8861;118.773;35.9474;8.55785;36.6615;71.1126 15 1 15 78968;293820;298490;313245;296371;362094;364975;114027;50549;29277;25599;25612;25649;65155;24763 SREBF1_32750;PSAT1_9583;PPCS_9540;POLR1E_9523;PLTP_32412;MRPS2_9250;GCDH_8693;DAO_8437;CYP4A1_33111;CYP2C11_32593;CD74_8252;ASNS_8091;APOA2_33095;ALAS1_8018;ACSM3_7976 40.845038666666674 28.1893 28.93545654453073 28.858174666666667 23.1774 19.231163828894598 62.062810000000006 36.6615 45.04819647722631 41.2009;26.3316;15.1091;73.982;87.0256;63.3158;15.9021;6.1336;23.208;54.426;94.9138;28.1893;3.54778;27.1843;52.2057 31.4864;20.9188;7.94061;47.589;56.6266;45.3429;10.4227;2.43617;18.863;43.9518;58.8146;23.1774;1.51564;21.5215;42.2655 60.0774;35.2954;30.6311;165.722;104.563;111.245;31.2818;16.2027;29.9853;74.8861;118.773;35.9474;8.55785;36.6615;71.1126 1 24950 SRD5A1_32503 29.2087 29.2087 22.9308 22.9308 39.9852 39.9852 29.2087 22.9308 39.9852 0 Exp 2,6(0.38);Hill,3(0.19);Linear,4(0.25);Poly 2,3(0.19) 1.980567609989435 32.636664032936096 1.5084086656570435 3.2609751224517822 0.5393956249502422 1.9072250127792358 26.34618658688753 53.88934841311246 19.355059116195818 37.620368383804184 39.18700799554563 82.17891075445435 UP 0.9375 0.0625 0.0 GO:0044255 4 cellular lipid metabolic process 218 243 37 36 32 37 31 31 65 212 2239 1.0 2.0721E-10 2.0721E-10 12.76 24950;24679;25664;364975;65030;25315;171142;291075;29740;64526;117543;50549;65210;25086;24303;499353;171521;29277;24894;311849;25413;25599;25649;502970;24763;50681;681337;314304;192272;50559;170465 srd5a1;prkar2b;pparg;gcdh;ephx2;ephx1;ehhadh;eci2;eci1;ech1;decr1;cyp4a1;cyp2j4;cyp2e1;cyp2d3;cyp2c24;cyp2c13;cyp2c11;cyp2a1;crat;cpt2;cd74;apoa2;angptl3;acsm3;acox1;acot4;acot3;acot2;acot1;acaa2 SRD5A1_32503;PRKAR2B_33052;PPARG_32510;GCDH_8693;EPHX2_33282;EPHX1_8567;EHHADH_8534;ECI2_8521;ECI1_8520;ECH1_8516;DECR1_8458;CYP4A1_33111;CYP2J4_32580;CYP2E1_8421;CYP2D3_8420;CYP2C24_32875;CYP2C13_8419;CYP2C11_32593;CYP2A1_32717;CRAT_8375;CPT2_8374;CD74_8252;APOA2_33095;ANGPTL3_8045;ACSM3_7976;ACOX1_7973;ACOT4_7971;ACOT3_7970;ACOT2_7969;ACOT1_7968;ACAA2_7955 25664(0.0441) 33.480004838709675 23.208 3.54778 30.184550503498738 36.62218210929572 32.05672959081499 22.400548387096773 18.863 1.51564 18.30629392119153 23.921311082524767 19.42435649308855 48.151050000000005 31.3726 8.55785 37.396096862513595 52.96041571225786 39.100954130257996 11.5 14.76915 23.5 56.249449999999996 29.2087;108.746;60.1903;15.9021;6.44145;34.0134;7.29984;8.72912;11.7653;9.87438;21.6199;23.208;16.3155;7.89174;12.8059;58.9435;104.635;54.426;9.37187;8.98517;31.2175;94.9138;3.54778;58.0729;52.2057;23.8014;12.3157;30.8838;13.6362;28.5134;78.3988 22.9308;59.3814;43.9036;10.4227;2.66377;26.1579;5.26587;5.10151;8.40998;6.59127;17.4928;18.863;8.2378;4.16797;8.8664;48.1505;49.2461;43.9518;4.95906;1.97988;24.8356;58.8146;1.51564;40.0757;42.2655;19.0993;6.70485;24.6874;11.3249;24.741;43.6084 39.9852;147.467;101.057;31.2818;17.3473;48.3681;11.8779;17.7951;18.8402;19.44;28.0829;29.9853;36.8422;15.8079;22.6004;80.4167;108.327;74.8861;19.1079;31.3726;42.0237;118.773;8.55785;105.112;71.1126;31.3543;24.3993;41.2585;16.9658;33.4642;98.7727 29 2 29 24679;25664;364975;65030;25315;171142;291075;29740;64526;117543;50549;65210;25086;24303;499353;171521;29277;24894;311849;25413;25599;25649;502970;24763;50681;681337;314304;192272;50559 PRKAR2B_33052;PPARG_32510;GCDH_8693;EPHX2_33282;EPHX1_8567;EHHADH_8534;ECI2_8521;ECI1_8520;ECH1_8516;DECR1_8458;CYP4A1_33111;CYP2J4_32580;CYP2E1_8421;CYP2D3_8420;CYP2C24_32875;CYP2C13_8419;CYP2C11_32593;CYP2A1_32717;CRAT_8375;CPT2_8374;CD74_8252;APOA2_33095;ANGPTL3_8045;ACSM3_7976;ACOX1_7973;ACOT4_7971;ACOT3_7970;ACOT2_7969;ACOT1_7968 32.078367241379304 21.6199 30.023976977044995 21.650958620689654 17.4928 18.504114520583702 46.68705689655173 31.3543 37.446463815105716 108.746;60.1903;15.9021;6.44145;34.0134;7.29984;8.72912;11.7653;9.87438;21.6199;23.208;16.3155;7.89174;12.8059;58.9435;104.635;54.426;9.37187;8.98517;31.2175;94.9138;3.54778;58.0729;52.2057;23.8014;12.3157;30.8838;13.6362;28.5134 59.3814;43.9036;10.4227;2.66377;26.1579;5.26587;5.10151;8.40998;6.59127;17.4928;18.863;8.2378;4.16797;8.8664;48.1505;49.2461;43.9518;4.95906;1.97988;24.8356;58.8146;1.51564;40.0757;42.2655;19.0993;6.70485;24.6874;11.3249;24.741 147.467;101.057;31.2818;17.3473;48.3681;11.8779;17.7951;18.8402;19.44;28.0829;29.9853;36.8422;15.8079;22.6004;80.4167;108.327;74.8861;19.1079;31.3726;42.0237;118.773;8.55785;105.112;71.1126;31.3543;24.3993;41.2585;16.9658;33.4642 2 24950;170465 SRD5A1_32503;ACAA2_7955 53.803749999999994 53.803749999999994 34.7826532772444 33.269600000000004 33.269600000000004 14.621271178662951 69.37895 69.37895 41.569039899004146 29.2087;78.3988 22.9308;43.6084 39.9852;98.7727 0 Exp 2,8(0.26);Exp 4,4(0.13);Hill,6(0.2);Linear,6(0.2);Poly 2,5(0.17);Power,2(0.07) 2.341446456248849 117.65167546272278 1.5239794254302979 50.888092041015625 8.774926782987752 1.940477728843689 22.854246431651955 44.105763245767406 15.956249787632 28.844846986561553 34.986636947636 61.315463052363995 UP 0.9354838709677419 0.06451612903225806 0.0 GO:0007584 4 response to nutrient 144 154 6 6 5 6 5 5 91 149 2302 0.47097 0.70084 1.0 3.25 25664;24614;63868;58868;114628 pparg;orm1;hspd1;fzd1;abcg5 PPARG_32510;ORM1_9400;HSPD1_8849;FZD1_8671;ABCG5_7947 25664(0.0441) 35.44612 33.1119 24.2519 14.563511812814925 36.92673896025519 15.468050875775035 25.639319999999998 24.2098 13.6792 11.345649328134556 27.02376273529327 11.587238392910434 72.59852 50.4329 31.358 42.04625033801468 69.02686653159755 39.37151287813609 60.1903;24.2519;34.4455;25.231;33.1119 43.9036;19.7133;26.6907;13.6792;24.2098 101.057;31.358;48.4857;131.659;50.4329 4 1 4 25664;24614;63868;58868 PPARG_32510;ORM1_9400;HSPD1_8849;FZD1_8671 36.029675000000005 29.838250000000002 16.74885843400975 25.996699999999997 23.201999999999998 13.068290189360408 78.139925 74.77135 46.39470258002701 60.1903;24.2519;34.4455;25.231 43.9036;19.7133;26.6907;13.6792 101.057;31.358;48.4857;131.659 1 114628 ABCG5_7947 33.1119 33.1119 24.2098 24.2098 50.4329 50.4329 33.1119 24.2098 50.4329 0 Exp 2,4(0.8);Poly 2,1(0.2) 2.0319755459672626 10.809098601341248 1.5124053955078125 3.5849626064300537 0.9009746994186427 1.6557694673538208 22.680639057406456 48.21160094259355 15.694419886539203 35.5842201134608 35.74335660972847 109.45368339027155 UP 0.8 0.2 0.0 GO:0006694 6 steroid biosynthetic process 45 49 5 4 3 5 2 2 94 47 2404 0.71939 0.55804 0.70748 4.08 24950;25427 srd5a1;cyp51 SRD5A1_32503;CYP51_8429 52.18044999999999 52.18044999999999 29.2087 32.48696040144416 42.96959471334167 29.761096853131544 35.5144 35.5144 22.9308 17.795897783478058 30.46882364707984 16.302708255185852 105.68209999999999 105.68209999999999 39.9852 92.909446985869 79.33997810323272 85.11375075257645 29.2087;75.1522 22.9308;48.098 39.9852;171.379 0 2 0 2 24950;25427 SRD5A1_32503;CYP51_8429 52.18044999999999 52.18044999999999 32.48696040144416 35.5144 35.5144 17.795897783478058 105.68209999999999 105.68209999999999 92.909446985869 29.2087;75.1522 22.9308;48.098 39.9852;171.379 0 Linear,2(1) 1.785402498071694 3.5849066972732544 1.633623480796814 1.9512832164764404 0.22461935320899015 1.7924533486366272 7.1558199999999985 97.20507999999998 10.850544000000003 60.178256000000005 -23.08382400000002 234.448024 DOWN 0.0 1.0 0.0 GO:0030036 5 actin cytoskeleton organization 81 88 4 4 3 3 3 3 93 85 2366 0.5742 0.65356 1.0 3.41 64159;54133;25626 sptan1;pdlim1;krt8 SPTAN1_9932;PDLIM1_9452;KRT8_8978 61.20683333333333 67.1147 47.5519 11.861221160290944 65.173278565046 8.757808067970801 42.3315 45.3374 34.4152 6.921534102350453 44.63178449934297 5.156133304548315 114.71056666666668 123.914 76.6397 34.40510704188165 125.76546075689882 26.69052190485899 47.5519;67.1147;68.9539 34.4152;47.2419;45.3374 76.6397;123.914;143.578 3 0 3 64159;54133;25626 SPTAN1_9932;PDLIM1_9452;KRT8_8978 61.20683333333333 67.1147 11.861221160290944 42.3315 45.3374 6.921534102350453 114.71056666666668 123.914 34.40510704188165 47.5519;67.1147;68.9539 34.4152;47.2419;45.3374 76.6397;123.914;143.578 0 0 Exp 2,1(0.34);Linear,2(0.67) 1.576953188235083 4.733637690544128 1.5062377452850342 1.63596773147583 0.06591835747840512 1.5914322137832642 47.784598042902495 74.62906862376417 34.499046828693494 50.1639531713065 75.77752295489529 153.64361037843804 UP 1.0 0.0 0.0 GO:1901655 6 cellular response to ketone 66 69 3 3 3 3 3 3 93 66 2385 0.73891 0.48662 0.74377 4.35 286954;24950;25664 ugt2b1;srd5a1;pparg UGT2B10_33303,UGT2B1_33224;SRD5A1_32503;PPARG_32510 25664(0.0441) 33.98105 29.2087 12.54415 24.178924621403244 38.91003429800548 25.921325850338135 24.727548333333335 22.9308 7.348245 18.34379249839051 28.18972357003185 19.59172200378597 55.512683333333335 39.9852 25.495849999999997 40.10235530901936 64.69304110844182 42.97910934858473 12.54415;29.2087;60.1903 7.348245;22.9308;43.9036 25.495849999999997;39.9852;101.057 3 1 2 286954;25664 UGT2B10_33303,UGT2B1_33224;PPARG_32510 36.367225 36.367225 33.69091576243142 25.625922499999998 25.625922499999998 25.848539409181562 63.276425 63.276425 53.429801559253896 12.54415;60.1903 7.348245;43.9036 25.495849999999997;101.057 1 24950 SRD5A1_32503 29.2087 29.2087 22.9308 22.9308 39.9852 39.9852 29.2087 22.9308 39.9852 0 Exp 2,1(0.25);Exp 4,1(0.25);Linear,1(0.25);Poly 2,1(0.25) 1.7030377294405854 6.840380549430847 1.5239794254302979 1.9512832164764404 0.1814718861106327 1.6825589537620544 6.620021067789644 61.34207893221035 3.9695930010007032 45.48550366566596 10.13259629304465 100.892770373622 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0042790 9 nucleolar large rRNA transcription by RNA polymerase I 1 1 1 1 1 1 1 1 95 0 2451 1.0 0.037691 0.037691 100.0 313245 polr1e POLR1E_9523 73.982 73.982 73.982 73.982 47.589 47.589 47.589 47.589 165.722 165.722 165.722 165.722 0.0 73.982 0.0 73.982 73.982 47.589 165.722 1 0 1 313245 POLR1E_9523 73.982 73.982 47.589 47.589 165.722 165.722 73.982 47.589 165.722 0 0 Linear,1(1) 1.5184675455093384 1.5184675455093384 1.5184675455093384 1.5184675455093384 0.0 1.5184675455093384 73.982 73.982 47.589 47.589 165.722 165.722 UP 1.0 0.0 0.0 GO:0022607 5 cellular component assembly 355 395 14 13 10 14 9 9 87 386 2065 0.0545 0.97323 0.11236 2.28 308761;313245;54133;362094;316273;102551184;64515;25599;25649 prc1;polr1e;pdlim1;mrps2;mcm3;loc102551184;cdc20;cd74;apoa2 PRC1_9556;POLR1E_9523;PDLIM1_9452;MRPS2_9250;MCM3_9207;HIST1H4A_32934;CDC20_8255;CD74_8252;APOA2_33095 66.34204222222222 67.1147 3.54778 28.459991362332598 65.69926770679892 28.583436353619202 41.75476 47.2419 1.51564 16.697034660873186 41.60928634146342 17.118913100999904 155.33309444444444 118.773 8.55785 122.91833467664735 144.61972749824199 114.64102105014709 80.3005;73.982;67.1147;63.3158;54.0045;58.3303;101.569;94.9138;3.54778 50.2731;47.589;47.2419;45.3429;33.259;40.2068;51.5499;58.8146;1.51564 198.961;165.722;123.914;111.245;111.753;105.902;453.17;118.773;8.55785 5 4 5 313245;54133;362094;25599;25649 POLR1E_9523;PDLIM1_9452;MRPS2_9250;CD74_8252;APOA2_33095 60.574816 67.1147 34.136799483581946 40.100807999999994 47.2419 22.212434262847474 105.64237 118.773 58.250796849781366 73.982;67.1147;63.3158;94.9138;3.54778 47.589;47.2419;45.3429;58.8146;1.51564 165.722;123.914;111.245;118.773;8.55785 4 308761;316273;102551184;64515 PRC1_9556;MCM3_9207;HIST1H4A_32934;CDC20_8255 73.551075 69.3154 21.94158490908302 43.8222 45.23995 8.679166040966525 217.44650000000001 155.357 162.80926835308446 80.3005;54.0045;58.3303;101.569 50.2731;33.259;40.2068;51.5499 198.961;111.753;105.902;453.17 0 Exp 2,4(0.45);Hill,1(0.12);Linear,3(0.34);Poly 2,1(0.12) 1.6317503325989826 14.707915782928467 1.5184675455093384 1.7985904216766357 0.0954049931302501 1.6554155349731445 47.74818119883161 84.93590324561282 30.846030688229526 52.66348931177047 75.02644912236819 235.63973976652068 CONFLICT 0.5555555555555556 0.4444444444444444 0.0 GO:0097237 5 cellular response to toxic substance 71 80 3 3 2 3 2 2 94 78 2373 0.41187 0.81348 0.76801 2.5 286954;24471 ugt2b1;hspb1 UGT2B10_33303,UGT2B1_33224;HSPB1_8847 27.088175 27.088175 12.54415 20.568357406493345 27.50468245160139 20.55992143678499 19.1488225 19.1488225 7.348245 16.68853674433479 19.486763920064238 16.68169205627002 44.407725 44.407725 25.495849999999997 26.745430114904675 44.94931763761263 26.734460661494897 12.54415;41.6322 7.348245;30.9494 25.495849999999997;63.3196 3 0 2 286954;24471 UGT2B10_33303,UGT2B1_33224;HSPB1_8847 27.088175 27.088175 20.568357406493345 19.1488225 19.1488225 16.68853674433479 44.407725 44.407725 26.745430114904675 12.54415;41.6322 7.348245;30.9494 25.495849999999997;63.3196 0 0 Exp 4,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 1.7351737104807403 5.211966156959534 1.635288953781128 1.8468482494354248 0.10597850626022003 1.729828953742981 -1.4181139999999957 55.594463999999995 -3.980309399999996 42.2779544 7.340450000000004 81.475 UP 1.0 0.0 0.0 GO:0071900 8 regulation of protein serine/threonine kinase activity 142 154 9 9 7 9 7 7 89 147 2304 0.77879 0.36044 0.5163 4.55 24679;24471;29455;299626;25599;362485;114494 prkar2b;hspb1;gdf15;gadd45b;cd74;ccne2;ccna2 PRKAR2B_33052;HSPB1_8847;GDF15_33113;GADD45B_8679;CD74_8252;CCNE2_8227;CCNA2_8221 64.27785714285714 52.8265 21.3654 30.886130167323614 67.26156002322327 27.16029369916564 41.545814285714286 37.3288 17.8875 15.191441426060564 43.75001831363325 13.202261105703103 102.96831428571429 90.0448 26.3528 52.96087444228457 102.86804421353501 39.36746453322259 108.746;41.6322;21.3654;52.5718;94.9138;77.8893;52.8265 59.3814;30.9494;17.8875;37.1918;58.8146;49.2672;37.3288 147.467;63.3196;26.3528;89.36;118.773;185.461;90.0448 5 2 5 24679;24471;29455;299626;25599 PRKAR2B_33052;HSPB1_8847;GDF15_33113;GADD45B_8679;CD74_8252 63.845839999999995 52.5718 36.764045170356326 40.844939999999994 37.1918 18.061147699911 89.05447999999998 89.36 47.14098797662183 108.746;41.6322;21.3654;52.5718;94.9138 59.3814;30.9494;17.8875;37.1918;58.8146 147.467;63.3196;26.3528;89.36;118.773 2 362485;114494 CCNE2_8227;CCNA2_8221 65.3579 65.3579 17.72207583552222 43.298 43.298 8.441723596517472 137.7529 137.7529 67.46944205505184 77.8893;52.8265 49.2672;37.3288 185.461;90.0448 0 Exp 2,1(0.15);Linear,4(0.58);Poly 2,1(0.15);Power,1(0.15) 2.0316491485470913 15.6086345911026 1.5528020858764648 5.015069484710693 1.2569569192048093 1.6577342748641968 41.397091715362905 87.15862257035138 30.29183698612531 52.79979158530326 63.73434944828986 142.2022791231387 UP 0.7142857142857143 0.2857142857142857 0.0 GO:1903506 8 regulation of nucleic acid-templated transcription 474 508 15 15 11 15 11 11 85 497 1954 0.018644 0.99137 0.036431 2.17 360243;78968;25664;363465;54133;65035;259241;58868;306575;25599;114494 top2a;srebf1;pparg;pir;pdlim1;nr1i3;nr1d2;fzd1;ckap2;cd74;ccna2 TOP2A_10059;SREBF1_32750;PPARG_32510;PIR_9487;PDLIM1_9452;NR1I3_32602;NR1D2_9358;FZD1_8671;CKAP2_8324;CD74_8252;CCNA2_8221 25664(0.0441) 57.629736363636376 54.9577 22.095 24.260713047776324 57.52847493528606 22.95825741179618 35.53394545454545 40.9644 12.9529 14.735773686669033 37.16942500795947 14.536554514682319 109.37243636363637 102.838 55.8619 44.6490001222933 105.47433348652427 41.371845617964695 54.9577;41.2009;60.1903;52.1607;67.1147;22.095;99.0234;25.231;64.2131;94.9138;52.8265 18.8326;31.4864;43.9036;40.9644;47.2419;12.9529;42.5557;13.6792;43.1133;58.8146;37.3288 218.525;60.0774;101.057;74.9097;123.914;55.8619;102.838;131.659;125.437;118.773;90.0448 8 3 8 78968;25664;363465;54133;65035;259241;58868;25599 SREBF1_32750;PPARG_32510;PIR_9487;PDLIM1_9452;NR1I3_32602;NR1D2_9358;FZD1_8671;CD74_8252 57.741225 56.1755 28.8151026955236 36.449837499999994 41.76005 16.147164003001325 96.13625 101.94749999999999 29.24734225522524 41.2009;60.1903;52.1607;67.1147;22.095;99.0234;25.231;94.9138 31.4864;43.9036;40.9644;47.2419;12.9529;42.5557;13.6792;58.8146 60.0774;101.057;74.9097;123.914;55.8619;102.838;131.659;118.773 3 360243;306575;114494 TOP2A_10059;CKAP2_8324;CCNA2_8221 57.332433333333334 54.9577 6.0533613549278815 33.091566666666665 37.3288 12.68281151256825 144.66893333333334 125.437 66.36407833167979 54.9577;64.2131;52.8265 18.8326;43.1133;37.3288 218.525;125.437;90.0448 0 Exp 2,5(0.46);Linear,2(0.19);Poly 2,3(0.28);Power,1(0.1) 1.9299338961072539 21.657799124717712 1.5124053955078125 2.7270524501800537 0.42540834572081815 1.8577370643615723 43.29257114919369 71.96690157807903 26.825659696729495 44.242231212361425 82.98656344422263 135.7583092830501 UP 0.7272727272727273 0.2727272727272727 0.0 GO:0010646 5 regulation of cell communication 678 722 27 27 20 26 20 20 76 702 1749 0.057571 0.96572 0.10619 2.77 29142;365813;78968;24679;25664;24614;338475;24484;25685;63868;24471;29455;299626;58868;65210;64515;25599;25649;81633;170465 vnn1;trim59;srebf1;prkar2b;pparg;orm1;nrep;igfbp3;igfbp1;hspd1;hspb1;gdf15;gadd45b;fzd1;cyp2j4;cdc20;cd74;apoa2;acta2;acaa2 VNN1_10157;TRIM59_10085;SREBF1_32750;PRKAR2B_33052;PPARG_32510;ORM1_9400;NREP_9364;IGFBP3_8881;IGFBP1_32306;HSPD1_8849;HSPB1_8847;GDF15_33113;GADD45B_8679;FZD1_8671;CYP2J4_32580;CDC20_8255;CD74_8252;APOA2_33095;ACTA2_33040;ACAA2_7955 25664(0.0441) 54.539489 51.7589 3.54778 32.1969207716367 53.21295589624369 29.670685754147005 35.10583200000001 34.9675 1.51564 18.71142551612603 34.65383499067522 17.923762153522556 113.39618250000001 94.06635 8.55785 109.69681686537969 102.03507471706311 91.9475326258159 20.7328;56.1278;41.2009;108.746;60.1903;24.2519;69.4104;50.946;98.8371;34.4455;41.6322;21.3654;52.5718;25.231;16.3155;101.569;94.9138;3.54778;90.3558;78.3988 16.8296;33.6269;31.4864;59.3814;43.9036;19.7133;43.1468;36.3081;57.328;26.6907;30.9494;17.8875;37.1918;13.6792;8.2378;51.5499;58.8146;1.51564;70.2676;43.6084 26.7838;121.883;60.0774;147.467;101.057;31.358;157.944;85.0816;357.409;48.4857;63.3196;26.3528;89.36;131.659;36.8422;453.17;118.773;8.55785;103.57;98.7727 14 6 14 29142;78968;24679;25664;24614;25685;63868;24471;29455;299626;58868;65210;25599;25649 VNN1_10157;SREBF1_32750;PRKAR2B_33052;PPARG_32510;ORM1_9400;IGFBP1_32306;HSPD1_8849;HSPB1_8847;GDF15_33113;GADD45B_8679;FZD1_8671;CYP2J4_32580;CD74_8252;APOA2_33095 45.99871285714285 37.8232 33.25257050523612 30.25778142857143 28.820050000000002 18.965231980188566 89.10731071428572 61.698499999999996 88.47435700720594 20.7328;41.2009;108.746;60.1903;24.2519;98.8371;34.4455;41.6322;21.3654;52.5718;25.231;16.3155;94.9138;3.54778 16.8296;31.4864;59.3814;43.9036;19.7133;57.328;26.6907;30.9494;17.8875;37.1918;13.6792;8.2378;58.8146;1.51564 26.7838;60.0774;147.467;101.057;31.358;357.409;48.4857;63.3196;26.3528;89.36;131.659;36.8422;118.773;8.55785 6 365813;338475;24484;64515;81633;170465 TRIM59_10085;NREP_9364;IGFBP3_8881;CDC20_8255;ACTA2_33040;ACAA2_7955 74.46796666666667 73.90459999999999 19.58348445130913 46.41795 43.3776 13.263157516783107 170.07021666666665 112.72649999999999 140.9561775635026 56.1278;69.4104;50.946;101.569;90.3558;78.3988 33.6269;43.1468;36.3081;51.5499;70.2676;43.6084 121.883;157.944;85.0816;453.17;103.57;98.7727 0 Exp 2,8(0.4);Exp 4,1(0.05);Hill,1(0.05);Linear,5(0.25);Poly 2,4(0.2);Power,1(0.05) 1.9718467300207014 42.52993583679199 1.5124053955078125 5.015069484710693 1.0268148862095567 1.7274702787399292 40.42856631173528 68.65041168826471 26.905188195643547 43.30647580435645 65.31943277243849 161.47293222756156 UP 0.7 0.3 0.0 GO:0006351 7 transcription, DNA-templated 63 70 3 3 2 3 2 2 94 68 2383 0.50366 0.7501 1.0 2.86 78968;313245 srebf1;polr1e SREBF1_32750;POLR1E_9523 57.591449999999995 57.591449999999995 41.2009 23.179738104754367 46.422283541666665 16.964660322478704 39.5377 39.5377 31.4864 11.38625765473448 34.05122700757576 8.333312161847687 112.8997 112.8997 60.0774 74.70201305574038 76.90450390151514 54.672501957046414 41.2009;73.982 31.4864;47.589 60.0774;165.722 2 0 2 78968;313245 SREBF1_32750;POLR1E_9523 57.591449999999995 57.591449999999995 23.179738104754367 39.5377 39.5377 11.38625765473448 112.8997 112.8997 74.70201305574038 41.2009;73.982 31.4864;47.589 60.0774;165.722 0 0 Exp 2,1(0.5);Linear,1(0.5) 1.7041576773198086 3.4310230016708374 1.5184675455093384 1.912555456161499 0.27866223400578105 1.7155115008354187 25.465971999999994 89.716928 23.757152000000005 55.318248 9.367991999999987 216.431408 UP 1.0 0.0 0.0 GO:0050877 4 nervous system process 155 163 3 3 2 3 2 2 94 161 2290 0.047501 0.98792 0.087525 1.23 24679;65030 prkar2b;ephx2 PRKAR2B_33052;EPHX2_33282 57.593725 57.593725 6.44145 72.34024105123821 39.909595337067614 67.87969940623219 31.022585 31.022585 2.66377 40.105420785829565 21.218505679048743 37.632497043717976 82.40715 82.40715 17.3473 92.00852223595923 59.914957360455986 86.33522285009917 108.746;6.44145 59.3814;2.66377 147.467;17.3473 2 0 2 24679;65030 PRKAR2B_33052;EPHX2_33282 57.593725 57.593725 72.34024105123821 31.022585 31.022585 40.105420785829565 82.40715 82.40715 92.00852223595923 108.746;6.44145 59.3814;2.66377 147.467;17.3473 0 0 Exp 4,1(0.5);Power,1(0.5) 1.9615521926401736 3.9947431087493896 1.6208000183105469 2.3739430904388428 0.5325525735055872 1.9973715543746948 -42.66473399999999 157.852184 -24.5606924 86.6058624 -45.11015600000002 209.92445600000002 UP 1.0 0.0 0.0 GO:0000226 5 microtubule cytoskeleton organization 73 80 5 5 4 4 4 4 92 76 2375 0.81874 0.35614 0.54266 5.0 308761;304951;303575;64515 prc1;nuf2;kif18b;cdc20 PRC1_9556;NUF2_33136;KIF18B_32882;CDC20_8255 61.96295000000015 73.1414 5.73955E-13 43.81958193825344 68.3866993360368 34.84351394331047 36.44455000000014 47.114149999999995 5.73955E-13 24.522204100569468 41.22302240987486 19.165403143554173 196.01525000000015 165.4455 5.73957E-13 190.32090478167814 201.22227997861066 169.0205424199022 3.0 101.569 80.3005;5.73955E-13;65.9823;101.569 50.2731;5.73955E-13;43.9552;51.5499 198.961;5.73957E-13;131.93;453.17 0 4 0 4 308761;304951;303575;64515 PRC1_9556;NUF2_33136;KIF18B_32882;CDC20_8255 61.96295000000015 73.1414 43.81958193825344 36.44455000000014 47.114149999999995 24.522204100569468 196.01525000000015 165.4455 190.32090478167814 80.3005;5.73955E-13;65.9823;101.569 50.2731;5.73955E-13;43.9552;51.5499 198.961;5.73957E-13;131.93;453.17 0 Exp 2,1(0.25);Hill,1(0.25);Linear,2(0.5) 1.7201298477438802 6.898153781890869 1.5293418169021606 1.84699547290802 0.13974126672965875 1.7609082460403442 19.01975970051174 104.90614029948854 12.412789981442064 60.47631001855822 9.500763313955588 382.5297366860447 DOWN 0.0 1.0 0.0 GO:0032101 5 regulation of response to external stimulus 254 266 10 10 7 10 7 7 89 259 2192 0.19795 0.88959 0.39426 2.63 84386;309607;25664;259241;63868;24471;25599 slpi;rt1-ce5;pparg;nr1d2;hspd1;hspb1;cd74 SLPI_9890;RT1-CE5_32445;PPARG_32510;NR1D2_9358;HSPD1_8849;HSPB1_8847;CD74_8252 25664(0.0441) 62.681242857142855 54.8206 34.4455 24.9929922882967 61.8596135174013 22.99358102296614 38.189057142857145 37.8192 26.5902 11.521224775149735 39.288952551688595 11.814255258232265 96.40575714285715 101.057 48.4857 33.19910546896591 97.88241421087662 31.458147713700814 53.7429;54.8206;60.1903;99.0234;34.4455;41.6322;94.9138 37.8192;26.5902;43.9036;42.5557;26.6907;30.9494;58.8146 92.543;147.824;101.057;102.838;48.4857;63.3196;118.773 5 2 5 25664;259241;63868;24471;25599 PPARG_32510;NR1D2_9358;HSPD1_8849;HSPB1_8847;CD74_8252 66.04104 60.1903 29.789986227640327 40.5828 42.5557 12.580852676388837 86.89466 101.057 29.588942985818193 60.1903;99.0234;34.4455;41.6322;94.9138 43.9036;42.5557;26.6907;30.9494;58.8146 101.057;102.838;48.4857;63.3196;118.773 2 84386;309607 SLPI_9890;RT1-CE5_32445 54.28175 54.28175 0.7620489780842511 32.2047 32.2047 7.9401020459437515 120.18350000000001 120.18350000000001 39.08956997077355 53.7429;54.8206 37.8192;26.5902 92.543;147.824 0 Exp 2,3(0.43);Linear,2(0.29);Poly 2,1(0.15);Power,1(0.15) 1.8222359911333452 12.972959756851196 1.5239794254302979 2.7270524501800537 0.4017937153363408 1.714035153388977 44.16617506517018 81.19631064911553 29.654014387758924 46.72409989795537 71.81151563306445 120.99999865264986 UP 0.7142857142857143 0.2857142857142857 0.0 GO:1903707 6 negative regulation of hemopoiesis 45 48 2 2 2 2 2 2 94 46 2405 0.72979 0.54672 0.70212 4.17 102551184;25599 loc102551184;cd74 HIST1H4A_32934;CD74_8252 76.62205 76.62205 58.3303 25.868440929538068 89.5267025706125 18.333469944027847 49.5107 49.5107 40.2068 13.157701562963007 56.074511393208496 9.32512039647606 112.3375 112.3375 105.902 9.101171380651925 116.87768295779118 6.450178130839666 58.3303;94.9138 40.2068;58.8146 105.902;118.773 1 1 1 25599 CD74_8252 94.9138 94.9138 58.8146 58.8146 118.773 118.773 94.9138 58.8146 118.773 1 102551184 HIST1H4A_32934 58.3303 58.3303 40.2068 40.2068 105.902 105.902 58.3303 40.2068 105.902 0 Linear,1(0.5);Poly 2,1(0.5) 1.6565744992204945 3.3131498098373413 1.6554155349731445 1.6577342748641968 0.0016395967007707996 1.6565749049186707 40.77022000000001 112.47388 31.275056000000003 67.746344 99.72392 124.95108 CONFLICT 0.5 0.5 0.0 GO:0098542 4 defense response to other organism 155 169 5 5 4 5 4 4 92 165 2286 0.22379 0.89184 0.4066 2.37 29142;365813;84386;25211 vnn1;trim59;slpi;lyz2 VNN1_10157;TRIM59_10085;SLPI_9890;LYZ2_32611 52.107299999999995 54.93535 20.7328 23.555855297710313 59.39989885478029 18.27571358433486 34.379 35.72305 16.8296 13.43180688391055 38.67503042698767 10.55602865428208 106.5822 107.213 26.7838 65.74452376200875 124.67789429585453 55.91572650252592 20.7328;56.1278;53.7429;77.8257 16.8296;33.6269;37.8192;49.2403 26.7838;121.883;92.543;185.119 1 3 1 29142 VNN1_10157 20.7328 20.7328 16.8296 16.8296 26.7838 26.7838 20.7328 16.8296 26.7838 3 365813;84386;25211 TRIM59_10085;SLPI_9890;LYZ2_32611 62.56546666666666 56.1278 13.26943774405431 40.2288 37.8192 8.08079166975613 133.18166666666664 121.883 47.310927335377144 56.1278;53.7429;77.8257 33.6269;37.8192;49.2403 121.883;92.543;185.119 0 Exp 2,1(0.25);Linear,3(0.75) 2.1421409081980856 9.594997882843018 1.528815746307373 4.608505725860596 1.4762348344883 1.7288382053375244 29.022561808243907 75.1920381917561 21.215829253767666 47.54217074623233 42.15256671323142 171.0118332867686 DOWN 0.25 0.75 0.0 GO:0021794 4 thalamus development 1 1 1 1 1 1 1 1 95 0 2451 1.0 0.037691 0.037691 100.0 24950 srd5a1 SRD5A1_32503 29.2087 29.2087 29.2087 29.2087 22.9308 22.9308 22.9308 22.9308 39.9852 39.9852 39.9852 39.9852 0.0 29.2087 0.0 29.2087 29.2087 22.9308 39.9852 0 1 0 1 24950 SRD5A1_32503 29.2087 29.2087 22.9308 22.9308 39.9852 39.9852 29.2087 22.9308 39.9852 0 Linear,1(1) 1.9512832164764404 1.9512832164764404 1.9512832164764404 1.9512832164764404 0.0 1.9512832164764404 29.2087 29.2087 22.9308 22.9308 39.9852 39.9852 DOWN 0.0 1.0 0.0 GO:0007507 5 heart development 69 74 3 3 2 3 2 2 94 72 2379 0.46571 0.77739 1.0 2.7 25664;54133 pparg;pdlim1 PPARG_32510;PDLIM1_9452 25664(0.0441) 63.6525 63.6525 60.1903 4.896290195648092 63.581276653510336 4.89525404344158 45.57275 45.57275 43.9036 2.3605345676350975 45.53841274369094 2.36003503165947 112.4855 112.4855 101.057 16.162339697580947 112.25039630426981 16.158919425645795 60.1903;67.1147 43.9036;47.2419 101.057;123.914 2 0 2 25664;54133 PPARG_32510;PDLIM1_9452 63.6525 63.6525 4.896290195648092 45.57275 45.57275 2.3605345676350975 112.4855 112.4855 16.162339697580947 60.1903;67.1147 43.9036;47.2419 101.057;123.914 0 0 Exp 2,2(1) 1.5789810522729661 3.159947156906128 1.5239794254302979 1.63596773147583 0.07918769061839027 1.579973578453064 56.86658800000001 70.438412 42.301216 48.844284 90.08564 134.88536 UP 1.0 0.0 0.0 GO:0044351 7 macropinocytosis 4 4 1 1 1 1 1 1 95 3 2448 0.99197 0.14253 0.14253 25.0 315994 mapkapk3 MAPKAPK3_9194 104.193 104.193 104.193 104.19300000000001 59.1667 59.1667 59.1667 59.1667 434.985 434.985 434.985 434.98499999999996 0.0 104.193 0.0 104.193 104.193 59.1667 434.985 0 1 0 1 315994 MAPKAPK3_9194 104.193 104.193 59.1667 59.1667 434.985 434.985 104.193 59.1667 434.985 0 Linear,1(1) 1.5163835287094116 1.5163835287094116 1.5163835287094116 1.5163835287094116 0.0 1.5163835287094116 104.193 104.193 59.1667 59.1667 434.985 434.985 DOWN 0.0 1.0 0.0 GO:0010821 7 regulation of mitochondrion organization 47 48 2 2 2 2 2 2 94 46 2405 0.72979 0.54672 0.70212 4.17 78968;170465 srebf1;acaa2 SREBF1_32750;ACAA2_7955 59.79984999999999 59.79984999999999 41.2009 26.302887335899108 57.69001739512134 26.133103431544104 37.5474 37.5474 31.4864 8.571548401543303 36.859850680378756 8.516219458549457 79.42505 79.42505 60.0774 27.361709030047805 77.23028616667712 27.18509048130753 41.2009;78.3988 31.4864;43.6084 60.0774;98.7727 1 1 1 78968 SREBF1_32750 41.2009 41.2009 31.4864 31.4864 60.0774 60.0774 41.2009 31.4864 60.0774 1 170465 ACAA2_7955 78.3988 78.3988 43.6084 43.6084 98.7727 98.7727 78.3988 43.6084 98.7727 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.8182991771207229 3.641243577003479 1.72868812084198 1.912555456161499 0.1300138396431327 1.8206217885017395 23.345907999999994 96.25379199999999 25.667839999999998 49.42696000000001 41.50365599999999 117.346444 CONFLICT 0.5 0.5 0.0 GO:0071314 6 cellular response to cocaine 1 1 1 1 1 1 1 1 95 0 2451 1.0 0.037691 0.037691 100.0 114494 ccna2 CCNA2_8221 52.8265 52.8265 52.8265 52.8265 37.3288 37.3288 37.3288 37.3288 90.0448 90.0448 90.0448 90.04480000000001 0.0 52.8265 0.0 52.8265 52.8265 37.3288 90.0448 0 1 0 1 114494 CCNA2_8221 52.8265 52.8265 37.3288 37.3288 90.0448 90.0448 52.8265 37.3288 90.0448 0 Linear,1(1) 2.3255980014801025 2.3255980014801025 2.3255980014801025 2.3255980014801025 0.0 2.3255980014801025 52.8265 52.8265 37.3288 37.3288 90.0448 90.0448 DOWN 0.0 1.0 0.0 GO:0046888 6 negative regulation of hormone secretion 24 25 3 3 3 3 3 3 93 22 2429 0.98696 0.065518 0.065518 12.0 78968;25664;24484 srebf1;pparg;igfbp3 SREBF1_32750;PPARG_32510;IGFBP3_8881 25664(0.0441) 50.779066666666665 50.946 41.2009 9.495800553051522 50.60275945605754 10.288165320407812 37.2327 36.3081 31.4864 6.26002219085525 37.297326743088334 6.756116988035486 82.072 85.0816 60.0774 20.65490675747534 81.2304334726905 22.335672748315798 0.5 46.073449999999994 1.5 55.56815 41.2009;60.1903;50.946 31.4864;43.9036;36.3081 60.0774;101.057;85.0816 2 1 2 78968;25664 SREBF1_32750;PPARG_32510 50.6956 50.6956 13.427533510663821 37.695 37.695 8.780286323349577 80.5672 80.5672 28.976953050312247 41.2009;60.1903 31.4864;43.9036 60.0774;101.057 1 24484 IGFBP3_8881 50.946 50.946 36.3081 36.3081 85.0816 85.0816 50.946 36.3081 85.0816 0 Exp 2,2(0.67);Linear,1(0.34) 1.7174389632189566 5.174538969993591 1.5239794254302979 1.912555456161499 0.19462188469168523 1.7380040884017944 40.033556775935104 61.52457655739823 30.14881802583433 44.31658197416567 58.698772686030594 105.44522731396941 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0045416 8 positive regulation of interleukin-8 biosynthetic process 8 9 2 2 2 2 2 2 94 7 2444 0.9963 0.042588 0.042588 22.22 25599;25649 cd74;apoa2 CD74_8252;APOA2_33095 49.23079 49.23079 3.54778 64.60553231202573 55.84126815819371 63.925565796168655 30.165119999999998 30.165119999999998 1.51564 40.51648317093674 34.31079170122125 40.09005139473116 63.665425 63.665425 8.55785 77.9338799544925 71.63966796009657 77.11363396435125 0.0 3.54778 0.0 3.54778 94.9138;3.54778 58.8146;1.51564 118.773;8.55785 2 0 2 25599;25649 CD74_8252;APOA2_33095 49.23079 49.23079 64.60553231202573 30.165119999999998 30.165119999999998 40.51648317093674 63.665425 63.665425 77.9338799544925 94.9138;3.54778 58.8146;1.51564 118.773;8.55785 0 0 Hill,1(0.5);Poly 2,1(0.5) 1.691646485316139 3.383986711502075 1.6577342748641968 1.7262524366378784 0.04844965682460717 1.6919933557510376 -40.307909599999974 138.76948959999999 -25.987860799999996 86.3181008 -44.345422 171.67627199999998 UP 1.0 0.0 0.0 GO:0050766 6 positive regulation of phagocytosis 30 35 4 4 2 4 2 2 94 33 2418 0.85695 0.38281 0.38281 5.71 25664;25649 pparg;apoa2 PPARG_32510;APOA2_33095 25664(0.0441) 31.869040000000002 31.869040000000002 3.54778 40.05230999549464 36.752686784831 39.45234497640438 22.709619999999997 22.709619999999997 1.51564 29.972813956664126 26.364256562242375 29.523835111256158 54.807425 54.807425 8.55785 65.40677621899164 62.78258529472382 64.4270130605802 0.5 31.869040000000002 60.1903;3.54778 43.9036;1.51564 101.057;8.55785 2 0 2 25664;25649 PPARG_32510;APOA2_33095 31.869040000000002 31.869040000000002 40.05230999549464 22.709619999999997 22.709619999999997 29.972813956664126 54.807425 54.807425 65.40677621899164 60.1903;3.54778 43.9036;1.51564 101.057;8.55785 0 0 Exp 2,1(0.5);Hill,1(0.5) 1.6219658432084954 3.2502318620681763 1.5239794254302979 1.7262524366378784 0.14302861787590274 1.6251159310340881 -23.640629599999993 87.3787096 -18.830580800000003 64.2498208 -35.84174199999999 145.456592 UP 1.0 0.0 0.0 GO:0006869 6 lipid transport 73 76 9 9 6 9 6 6 90 70 2381 0.97739 0.064182 0.064182 7.89 25664;296371;25413;25649;114628;140668 pparg;pltp;cpt2;apoa2;abcg5;abcc3 PPARG_32510;PLTP_32412;CPT2_8374;APOA2_33095;ABCG5_7947;ABCC3_7941 25664(0.0441) 41.64509666666667 33.9447 3.54778 28.577733598843455 44.34886814120587 29.101049393301995 29.624573333333334 25.7459 1.51564 18.890089760916084 31.305624901593255 19.269029678905337 59.400825 50.101699999999994 8.55785 36.97295872631443 64.06341445772155 37.97022436136187 2.5 33.9447 60.1903;87.0256;31.2175;3.54778;33.1119;34.7775 43.9036;56.6266;24.8356;1.51564;24.2098;26.6562 101.057;104.563;42.0237;8.55785;50.4329;49.7705 5 1 5 25664;296371;25413;25649;140668 PPARG_32510;PLTP_32412;CPT2_8374;APOA2_33095;ABCC3_7941 43.351736 34.7775 31.607181754349437 30.707528000000003 26.6562 20.910486194584763 61.19440999999999 49.7705 41.04415296458802 60.1903;87.0256;31.2175;3.54778;34.7775 43.9036;56.6266;24.8356;1.51564;26.6562 101.057;104.563;42.0237;8.55785;49.7705 1 114628 ABCG5_7947 33.1119 33.1119 24.2098 24.2098 50.4329 50.4329 33.1119 24.2098 50.4329 0 Exp 2,3(0.5);Hill,1(0.17);Linear,1(0.17);Poly 2,1(0.17) 1.8309844928193757 11.16555941104889 1.5084086656570435 2.5319817066192627 0.3808683593266616 1.801587164402008 18.77814732802996 64.51204600530338 14.509353504191614 44.739793162475046 29.81629650091869 88.9853534990813 UP 0.8333333333333334 0.16666666666666666 0.0 GO:0070257 6 positive regulation of mucus secretion 3 3 1 1 1 1 1 1 95 2 2449 0.99588 0.10891 0.10891 33.33 361604 sytl2 SYTL2_32351 67.0093 67.0093 67.0093 67.0093 44.4373 44.4373 44.4373 44.4373 135.846 135.846 135.846 135.846 0.0 67.0093 0.0 67.0093 67.0093 44.4373 135.846 0 1 0 1 361604 SYTL2_32351 67.0093 67.0093 44.4373 44.4373 135.846 135.846 67.0093 44.4373 135.846 0 Linear,1(1) 1.512166976928711 1.512166976928711 1.512166976928711 1.512166976928711 0.0 1.512166976928711 67.0093 67.0093 44.4373 44.4373 135.846 135.846 DOWN 0.0 1.0 0.0 GO:0019748 3 secondary metabolic process 18 25 2 2 2 2 2 2 94 23 2428 0.93448 0.24238 0.24238 8.0 24894;26760 cyp2a1;akr7a3 CYP2A1_32717;AKR7A3_8015 14.095434999999998 14.095434999999998 9.37187 6.680129685750869 14.71180764398557 6.6230130715515365 8.25298 8.25298 4.95906 4.658306337371984 8.682799888045777 4.61847676842492 35.3742 35.3742 19.1079 23.004022069629478 37.496771053613635 22.80733249691255 0.5 14.095434999999998 9.37187;18.819 4.95906;11.5469 19.1079;51.6405 2 0 2 24894;26760 CYP2A1_32717;AKR7A3_8015 14.095434999999998 14.095434999999998 6.680129685750869 8.25298 8.25298 4.658306337371984 35.3742 35.3742 23.004022069629478 9.37187;18.819 4.95906;11.5469 19.1079;51.6405 0 0 Exp 4,1(0.5);Poly 2,1(0.5) 1.7057272490566764 3.4124945402145386 1.664124846458435 1.7483696937561035 0.05957010280420656 1.7062472701072693 4.8372475999999995 23.3536224 1.7968968000000007 14.709063200000001 3.492252000000004 67.256148 UP 1.0 0.0 0.0 GO:0070374 9 positive regulation of ERK1 and ERK2 cascade 75 80 3 3 2 3 2 2 94 78 2373 0.41187 0.81348 0.76801 2.5 25599;81633 cd74;acta2 CD74_8252;ACTA2_33040 92.6348 92.6348 90.3558 3.2229927086483605 93.1067761904762 3.1531189243742634 64.5411 64.5411 58.8146 8.098493964929531 63.355153683737655 7.92292036877097 111.1715 111.1715 103.57 10.750144394379063 112.74575494159929 10.51708359088647 94.9138;90.3558 58.8146;70.2676 118.773;103.57 1 1 1 25599 CD74_8252 94.9138 94.9138 58.8146 58.8146 118.773 118.773 94.9138 58.8146 118.773 1 81633 ACTA2_33040 90.3558 90.3558 70.2676 70.2676 103.57 103.57 90.3558 70.2676 103.57 0 Poly 2,2(1) 1.6289293383461187 3.25835919380188 1.600624918937683 1.6577342748641968 0.040382412844833966 1.62917959690094 88.16796000000001 97.10163999999999 53.31716 75.76504 96.27256 126.07043999999999 CONFLICT 0.5 0.5 0.0 GO:0034754 5 cellular hormone metabolic process 34 41 4 4 3 4 3 3 93 38 2413 0.93378 0.1993 0.1993 7.32 360268;24950;499353 sult1e1;srd5a1;cyp2c24 SULT1E1_32446;SRD5A1_32503;CYP2C24_32875 49.14169999999999 58.9435 29.2087 17.263270050601676 53.29590831966603 14.516939628494315 38.79756666666666 45.3114 22.9308 13.814153450115345 41.95613846230306 11.569515830220721 70.65323333333333 80.4167 39.9852 27.13719271964832 77.55288429004524 23.44140370896236 1.5 59.1082 59.2729;29.2087;58.9435 45.3114;22.9308;48.1505 91.5578;39.9852;80.4167 2 1 2 360268;499353 SULT1E1_32446;CYP2C24_32875 59.1082 59.1082 0.2329209737244174 46.73095 46.73095 2.0075468624668025 85.98725 85.98725 7.877947359877413 59.2729;58.9435 45.3114;48.1505 91.5578;80.4167 1 24950 SRD5A1_32503 29.2087 29.2087 22.9308 22.9308 39.9852 39.9852 29.2087 22.9308 39.9852 0 Exp 2,2(0.67);Linear,1(0.34) 2.493038918134177 7.592715501785278 1.9512832164764404 2.9455835819244385 0.5172650014876186 2.6958487033843994 29.606470922816186 68.67692907718381 23.165380449086935 54.4297528842464 39.94460891072351 101.36185775594316 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0051783 7 regulation of nuclear division 47 50 2 2 2 2 2 2 94 48 2403 0.70895 0.56917 0.71286 4.0 291234;64515 mki67;cdc20 MKI67_9232;CDC20_8255 75.6756 75.6756 49.7822 36.6187974559515 78.61856055705302 36.381510323779274 43.6082 43.6082 35.6665 11.231259848298423 44.510828077268634 11.158482105029048 267.64235 267.64235 82.1147 262.3757188252087 288.7288259433962 260.6755433361983 49.7822;101.569 35.6665;51.5499 82.1147;453.17 0 2 0 2 291234;64515 MKI67_9232;CDC20_8255 75.6756 75.6756 36.6187974559515 43.6082 43.6082 11.231259848298423 267.64235 267.64235 262.3757188252087 49.7822;101.569 35.6665;51.5499 82.1147;453.17 0 Exp 2,1(0.5);Linear,1(0.5) 1.8696266162538004 3.81496798992157 1.5293418169021606 2.285626173019409 0.5347737967158083 1.907483994960785 24.924536000000003 126.426664 28.042467999999996 59.17393199999999 -95.99184400000001 631.276544 DOWN 0.0 1.0 0.0 GO:0006468 7 protein phosphorylation 190 202 6 6 3 5 3 3 93 199 2252 0.045302 0.98586 0.082347 1.49 315994;24484;114494 mapkapk3;igfbp3;ccna2 MAPKAPK3_9194;IGFBP3_8881;CCNA2_8221 69.32183333333334 52.8265 50.946 30.213949900390915 75.40012842932269 31.952173458972965 44.26786666666666 37.3288 36.3081 12.912857280375023 46.85797182411456 13.66224811364862 203.37046666666666 90.0448 85.0816 200.5994201810497 243.98052412088956 211.89965317446655 104.193;50.946;52.8265 59.1667;36.3081;37.3288 434.985;85.0816;90.0448 0 3 0 3 315994;24484;114494 MAPKAPK3_9194;IGFBP3_8881;CCNA2_8221 69.32183333333334 52.8265 30.213949900390915 44.26786666666666 37.3288 12.912857280375023 203.37046666666666 90.0448 200.5994201810497 104.193;50.946;52.8265 59.1667;36.3081;37.3288 434.985;85.0816;90.0448 0 Linear,3(1) 1.8300579094640688 5.579985618591309 1.5163835287094116 2.3255980014801025 0.4181726800630314 1.7380040884017944 35.131530401119086 103.51213626554758 29.655593078076503 58.88014025525683 -23.62914664532468 430.370079978658 DOWN 0.0 1.0 0.0 GO:0016192 4 vesicle-mediated transport 163 173 2 2 2 2 2 2 94 171 2280 0.035137 0.99154 0.062009 1.16 361604;315994 sytl2;mapkapk3 SYTL2_32351;MAPKAPK3_9194 85.60114999999999 85.60114999999999 67.0093 26.292846419606263 85.84611063314577 26.290564113792236 51.802 51.802 44.4373 10.415258622809114 51.89903507584929 10.414354543998913 285.4155 285.4155 135.846 211.52321541736265 287.3861828217363 211.5048545044114 67.0093;104.193 44.4373;59.1667 135.846;434.985 0 2 0 2 361604;315994 SYTL2_32351;MAPKAPK3_9194 85.60114999999999 85.60114999999999 26.292846419606263 51.802 51.802 10.415258622809114 285.4155 285.4155 211.52321541736265 67.0093;104.193 44.4373;59.1667 135.846;434.985 0 Linear,2(1) 1.5142737851765784 3.0285505056381226 1.512166976928711 1.5163835287094116 0.0029815523573576658 1.5142752528190613 49.16112399999999 122.041176 37.367188 66.236812 -7.74072000000001 578.57172 DOWN 0.0 1.0 0.0 GO:0071394 6 cellular response to testosterone stimulus 7 8 2 2 2 2 2 2 94 6 2445 0.99747 0.033945 0.033945 25.0 286954;24950 ugt2b1;srd5a1 UGT2B10_33303,UGT2B1_33224;SRD5A1_32503 20.876425 20.876425 12.54415 11.783616310422277 19.522408071748877 11.62698970788522 15.139522500000002 15.139522500000002 7.348245 11.018530308712343 13.873419109545164 10.872073149743338 32.740525 32.740525 25.495849999999997 10.245517639985303 31.563245974802474 10.10933528501802 0.0 12.54415 0.0 12.54415 12.54415;29.2087 7.348245;22.9308 25.495849999999997;39.9852 2 1 1 286954 UGT2B10_33303,UGT2B1_33224 12.54415 12.54415 7.348245 7.348245 25.495849999999997 25.495849999999997 12.54415 7.348245 25.495849999999997 1 24950 SRD5A1_32503 29.2087 29.2087 22.9308 22.9308 39.9852 39.9852 29.2087 22.9308 39.9852 0 Exp 4,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 1.7672825586426997 5.316401124000549 1.635288953781128 1.9512832164764404 0.16218928043696426 1.729828953742981 4.545165999999998 37.207684 -0.13138139999999687 30.4104264 18.540961999999997 46.940088 CONFLICT 0.5 0.5 0.0 GO:0006067 6 ethanol metabolic process 3 4 2 2 2 2 2 2 94 2 2449 0.9998 0.0080285 0.0080285 50.0 360268;64305 sult1e1;sult1b1 SULT1E1_32446;SULT1B1_32942 37.3679 37.3679 15.4629 30.97834808378265 37.04515466209971 30.974985405867866 26.50279 26.50279 7.69418 26.599391351386217 26.225666457891588 26.596504006147477 63.32285 63.32285 35.0879 39.930249222926214 62.90684002609689 39.925914822433626 0.0 15.4629 0.0 15.4629 59.2729;15.4629 45.3114;7.69418 91.5578;35.0879 2 0 2 360268;64305 SULT1E1_32446;SULT1B1_32942 37.3679 37.3679 30.97834808378265 26.50279 26.50279 26.599391351386217 63.32285 63.32285 39.930249222926214 59.2729;15.4629 45.3114;7.69418 91.5578;35.0879 0 0 Exp 2,1(0.5);Exp 4,1(0.5) 2.1840240828694406 4.564943909645081 1.619360327720642 2.9455835819244385 0.9377814564147948 2.2824719548225403 -5.565899999999999 80.3017 -10.362085599999997 63.367665599999995 7.982348000000009 118.663352 UP 1.0 0.0 0.0 GO:0006068 6 ethanol catabolic process 3 4 2 2 2 2 2 2 94 2 2449 0.9998 0.0080285 0.0080285 50.0 360268;64305 sult1e1;sult1b1 SULT1E1_32446;SULT1B1_32942 37.3679 37.3679 15.4629 30.97834808378265 37.04515466209971 30.974985405867866 26.50279 26.50279 7.69418 26.599391351386217 26.225666457891588 26.596504006147477 63.32285 63.32285 35.0879 39.930249222926214 62.90684002609689 39.925914822433626 0.0 15.4629 0.0 15.4629 59.2729;15.4629 45.3114;7.69418 91.5578;35.0879 2 0 2 360268;64305 SULT1E1_32446;SULT1B1_32942 37.3679 37.3679 30.97834808378265 26.50279 26.50279 26.599391351386217 63.32285 63.32285 39.930249222926214 59.2729;15.4629 45.3114;7.69418 91.5578;35.0879 0 0 Exp 2,1(0.5);Exp 4,1(0.5) 2.1840240828694406 4.564943909645081 1.619360327720642 2.9455835819244385 0.9377814564147948 2.2824719548225403 -5.565899999999999 80.3017 -10.362085599999997 63.367665599999995 7.982348000000009 118.663352 UP 1.0 0.0 0.0 GO:0034310 6 primary alcohol catabolic process 3 4 2 2 2 2 2 2 94 2 2449 0.9998 0.0080285 0.0080285 50.0 360268;64305 sult1e1;sult1b1 SULT1E1_32446;SULT1B1_32942 37.3679 37.3679 15.4629 30.97834808378265 37.04515466209971 30.974985405867866 26.50279 26.50279 7.69418 26.599391351386217 26.225666457891588 26.596504006147477 63.32285 63.32285 35.0879 39.930249222926214 62.90684002609689 39.925914822433626 0.0 15.4629 0.0 15.4629 59.2729;15.4629 45.3114;7.69418 91.5578;35.0879 2 0 2 360268;64305 SULT1E1_32446;SULT1B1_32942 37.3679 37.3679 30.97834808378265 26.50279 26.50279 26.599391351386217 63.32285 63.32285 39.930249222926214 59.2729;15.4629 45.3114;7.69418 91.5578;35.0879 0 0 Exp 2,1(0.5);Exp 4,1(0.5) 2.1840240828694406 4.564943909645081 1.619360327720642 2.9455835819244385 0.9377814564147948 2.2824719548225403 -5.565899999999999 80.3017 -10.362085599999997 63.367665599999995 7.982348000000009 118.663352 UP 1.0 0.0 0.0 GO:0071295 6 cellular response to vitamin 12 14 2 2 2 2 2 2 94 12 2439 0.98604 0.095353 0.095353 14.29 25664;58868 pparg;fzd1 PPARG_32510;FZD1_8671 25664(0.0441) 42.71065 42.71065 25.231 24.719958095534874 47.919447436872524 23.596889345171334 28.7914 28.7914 13.6792 21.371878197294677 33.29471606327959 20.400918277087808 116.358 116.358 101.057 21.638881717870667 111.79842303011863 20.65579138429375 0.0 25.231 0.5 42.71065 60.1903;25.231 43.9036;13.6792 101.057;131.659 2 0 2 25664;58868 PPARG_32510;FZD1_8671 42.71065 42.71065 24.719958095534874 28.7914 28.7914 21.371878197294677 116.358 116.358 21.638881717870667 60.1903;25.231 43.9036;13.6792 101.057;131.659 0 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.5181813810160096 3.0363848209381104 1.5124053955078125 1.5239794254302979 0.008184075043845404 1.5181924104690552 8.450536000000007 76.970764 -0.8285119999999964 58.411311999999995 86.36804000000001 146.34796 UP 1.0 0.0 0.0 GO:0045765 6 regulation of angiogenesis 105 108 3 3 3 3 3 3 93 105 2346 0.41145 0.78393 0.79678 2.78 25664;24471;502970 pparg;hspb1;angptl3 PPARG_32510;HSPB1_8847;ANGPTL3_8045 25664(0.0441) 53.29846666666666 58.0729 41.6322 10.158601239508043 54.903470926293174 9.158240645960849 38.30956666666666 40.0757 30.9494 6.6552418906703394 39.25147058337465 6.040438244571499 89.82953333333334 101.057 63.3196 23.0476285169067 93.72815844488515 20.93625869504245 60.1903;41.6322;58.0729 43.9036;30.9494;40.0757 101.057;63.3196;105.112 3 0 3 25664;24471;502970 PPARG_32510;HSPB1_8847;ANGPTL3_8045 53.29846666666666 58.0729 10.158601239508043 38.30956666666666 40.0757 6.6552418906703394 89.82953333333334 101.057 23.0476285169067 60.1903;41.6322;58.0729 43.9036;30.9494;40.0757 101.057;63.3196;105.112 0 0 Exp 2,1(0.34);Linear,2(0.67) 1.6296106670970725 4.908420205116272 1.5239794254302979 1.8468482494354248 0.18260553751454497 1.5375925302505493 41.80292719263545 64.79400614069787 30.778451500349497 45.840681832983826 63.74868645763286 115.9103802090338 UP 1.0 0.0 0.0 GO:0001933 9 negative regulation of protein phosphorylation 121 130 7 7 4 7 4 4 92 126 2325 0.45101 0.73317 1.0 3.08 24679;24484;24471;299626 prkar2b;igfbp3;hspb1;gadd45b PRKAR2B_33052;IGFBP3_8881;HSPB1_8847;GADD45B_8679 63.474000000000004 51.7589 41.6322 30.563741917943652 57.67861920809502 24.953053008933775 40.957675 36.74995 30.9494 12.588348760494089 38.67045977122744 10.326401580064609 96.30705 87.2208 63.3196 35.961945502201814 90.35575501099868 29.875158635881284 108.746;50.946;41.6322;52.5718 59.3814;36.3081;30.9494;37.1918 147.467;85.0816;63.3196;89.36 3 1 3 24679;24471;299626 PRKAR2B_33052;HSPB1_8847;GADD45B_8679 67.64999999999999 52.5718 36.00804943398075 42.507533333333335 37.1918 14.942805012892784 100.04886666666668 89.36 43.07998531398696 108.746;41.6322;52.5718 59.3814;30.9494;37.1918 147.467;63.3196;89.36 1 24484 IGFBP3_8881 50.946 50.946 36.3081 36.3081 85.0816 85.0816 50.946 36.3081 85.0816 0 Linear,3(0.75);Power,1(0.25) 1.685900292967141 6.758454442024231 1.5528020858764648 1.8468482494354248 0.12976526727460627 1.6794020533561707 33.52153292041521 93.4264670795848 28.621093214715792 53.294256785284226 61.064343407842216 131.5497565921578 UP 0.75 0.25 0.0 GO:0019217 7 regulation of fatty acid metabolic process 42 45 5 5 3 5 3 3 93 42 2409 0.91293 0.23933 0.23933 6.67 78968;25664;25599 srebf1;pparg;cd74 SREBF1_32750;PPARG_32510;CD74_8252 25664(0.0441) 65.435 60.1903 41.2009 27.23782416365154 64.56051986102386 27.059723324483166 44.73486666666667 43.9036 31.4864 13.683050902972367 44.29452609139447 13.635409705681102 93.30246666666666 101.057 60.0774 30.106360710875233 92.38048410804019 30.232967734546637 1.5 77.55205 41.2009;60.1903;94.9138 31.4864;43.9036;58.8146 60.0774;101.057;118.773 3 0 3 78968;25664;25599 SREBF1_32750;PPARG_32510;CD74_8252 65.435 60.1903 27.23782416365154 44.73486666666667 43.9036 13.683050902972367 93.30246666666666 101.057 30.106360710875233 41.2009;60.1903;94.9138 31.4864;43.9036;58.8146 60.0774;101.057;118.773 0 0 Exp 2,2(0.67);Poly 2,1(0.34) 1.6905811378761877 5.094269156455994 1.5239794254302979 1.912555456161499 0.19740631779979964 1.6577342748641968 34.61250037847313 96.25749962152688 29.251036947220413 60.218696386112924 59.23391236360881 127.37102096972451 UP 1.0 0.0 0.0 GO:0044260 4 cellular macromolecule metabolic process 676 733 24 23 20 23 19 19 77 714 1737 0.027832 0.98468 0.050593 2.59 365813;360243;78968;25664;313245;362094;291234;316273;315994;293502;24484;63868;171142;297594;64515;362485;114494;25649;65155 trim59;top2a;srebf1;pparg;polr1e;mrps2;mki67;mcm3;mapkapk3;kif22;igfbp3;hspd1;ehhadh;cdca3;cdc20;ccne2;ccna2;apoa2;alas1 TRIM59_10085;TOP2A_10059;SREBF1_32750;PPARG_32510;POLR1E_9523;MRPS2_9250;MKI67_9232;MCM3_9207;MAPKAPK3_9194;KIF22_8963;IGFBP3_8881;HSPD1_8849;EHHADH_8534;CDCA3_8260;CDC20_8255;CCNE2_8227;CCNA2_8221;APOA2_33095;ALAS1_8018 25664(0.0441) 54.42654842105264 54.0045 3.54778 26.192619775997386 54.9917805723256 25.401828936161824 34.05233736842106 35.6665 1.51564 15.423743388529918 34.874077697741726 14.800259727119666 137.87391842105265 111.245 8.55785 121.60231634957911 137.3952979256506 123.24769063334458 56.1278;54.9577;41.2009;60.1903;73.982;63.3158;49.7822;54.0045;104.193;73.9175;50.946;34.4455;7.29984;46.7245;101.569;77.8893;52.8265;3.54778;27.1843 33.6269;18.8326;31.4864;43.9036;47.589;45.3429;35.6665;33.259;59.1667;47.5608;36.3081;26.6907;5.26587;21.1123;51.5499;49.2672;37.3288;1.51564;21.5215 121.883;218.525;60.0774;101.057;165.722;111.245;82.1147;111.753;434.985;165.416;85.0816;48.4857;11.8779;127.486;453.17;185.461;90.0448;8.55785;36.6615 8 11 8 78968;25664;313245;362094;63868;171142;25649;65155 SREBF1_32750;PPARG_32510;POLR1E_9523;MRPS2_9250;HSPD1_8849;EHHADH_8534;APOA2_33095;ALAS1_8018 38.8958025 37.8232 25.886837955339246 27.91445125 29.088549999999998 17.774272140321592 67.96054375 54.281549999999996 54.27602533895895 41.2009;60.1903;73.982;63.3158;34.4455;7.29984;3.54778;27.1843 31.4864;43.9036;47.589;45.3429;26.6907;5.26587;1.51564;21.5215 60.0774;101.057;165.722;111.245;48.4857;11.8779;8.55785;36.6615 11 365813;360243;291234;316273;315994;293502;24484;297594;64515;362485;114494 TRIM59_10085;TOP2A_10059;MKI67_9232;MCM3_9207;MAPKAPK3_9194;KIF22_8963;IGFBP3_8881;CDCA3_8260;CDC20_8255;CCNE2_8227;CCNA2_8221 65.72163636363636 54.9577 20.79677768070202 38.516254545454544 36.3081 12.449895345051209 188.72000909090912 127.486 133.41866349903563 56.1278;54.9577;49.7822;54.0045;104.193;73.9175;50.946;46.7245;101.569;77.8893;52.8265 33.6269;18.8326;35.6665;33.259;59.1667;47.5608;36.3081;21.1123;51.5499;49.2672;37.3288 121.883;218.525;82.1147;111.753;434.985;165.416;85.0816;127.486;453.17;185.461;90.0448 0 Exp 2,9(0.48);Hill,2(0.11);Linear,8(0.43) 1.8348522317686642 35.95696759223938 1.5163835287094116 3.9502921104431152 0.5696646550245206 1.7262524366378784 42.64891020876271 66.20418663334259 27.116976527739848 40.98769820910225 83.1948485154828 192.55298832662248 CONFLICT 0.42105263157894735 0.5789473684210527 0.0 GO:0031099 4 regeneration 111 120 11 11 7 10 7 7 89 113 2338 0.92046 0.1634 0.21615 5.83 25664;24614;338475;291234;25685;114494;25649 pparg;orm1;nrep;mki67;igfbp1;ccna2;apoa2 PPARG_32510;ORM1_9400;NREP_9364;MKI67_9232;IGFBP1_32306;CCNA2_8221;APOA2_33095 25664(0.0441) 51.26374 52.8265 3.54778 30.776882132468625 45.39613278664656 27.282921000401252 34.08609142857143 37.3288 1.51564 18.253266914222447 31.258946859757682 17.38606448257819 118.35505 90.0448 8.55785 116.01152497793413 89.72767793016482 79.9410302225026 5.0 69.4104 60.1903;24.2519;69.4104;49.7822;98.8371;52.8265;3.54778 43.9036;19.7133;43.1468;35.6665;57.328;37.3288;1.51564 101.057;31.358;157.944;82.1147;357.409;90.0448;8.55785 4 3 4 25664;24614;25685;25649 PPARG_32510;ORM1_9400;IGFBP1_32306;APOA2_33095 46.706770000000006 42.2211 41.89787779711839 30.615135000000002 31.80845 24.871610818941743 124.5954625 66.2075 160.1188666670971 60.1903;24.2519;98.8371;3.54778 43.9036;19.7133;57.328;1.51564 101.057;31.358;357.409;8.55785 3 338475;291234;114494 NREP_9364;MKI67_9232;CCNA2_8221 57.33969999999999 52.8265 10.563772502756798 38.71403333333333 37.3288 3.927833443940005 110.03449999999998 90.0448 41.679872410913205 69.4104;49.7822;52.8265 43.1468;35.6665;37.3288 157.944;82.1147;90.0448 0 Exp 2,3(0.43);Hill,1(0.15);Linear,3(0.43) 2.1686074876052754 15.692717432975769 1.5239794254302979 3.5849626064300537 0.6631842726073082 2.2143635749816895 28.46390664931141 74.06357335068859 20.563882065106966 47.60830079203589 32.41250959348794 204.2975904065121 CONFLICT 0.5714285714285714 0.42857142857142855 0.0 GO:0051129 6 negative regulation of cellular component organization 177 187 6 6 5 6 5 5 91 182 2269 0.27983 0.84673 0.54944 2.67 360243;64159;306575;25649;170465 top2a;sptan1;ckap2;apoa2;acaa2 TOP2A_10059;SPTAN1_9932;CKAP2_8324;APOA2_33095;ACAA2_7955 49.733856 54.9577 3.54778 28.268934432229305 51.848077186501385 29.900794526664818 28.297028 34.4152 1.51564 18.015342056811473 29.68906399971907 18.98994256121377 105.58645000000001 98.7727 8.55785 76.56378248556886 104.64031849387226 72.97851522657888 54.9577;47.5519;64.2131;3.54778;78.3988 18.8326;34.4152;43.1133;1.51564;43.6084 218.525;76.6397;125.437;8.55785;98.7727 2 3 2 64159;25649 SPTAN1_9932;APOA2_33095 25.549840000000003 25.549840000000003 31.115611652146576 17.965419999999998 17.965419999999998 23.263501974053693 42.598775 42.598775 48.14113781072536 47.5519;3.54778 34.4152;1.51564 76.6397;8.55785 3 360243;306575;170465 TOP2A_10059;CKAP2_8324;ACAA2_7955 65.85653333333333 64.2131 11.806648429733725 35.18476666666667 43.1133 14.163555239534075 147.57823333333332 125.437 62.87152772888006 54.9577;64.2131;78.3988 18.8326;43.1133;43.6084 218.525;125.437;98.7727 0 Exp 2,1(0.2);Hill,1(0.2);Linear,2(0.4);Poly 2,1(0.2) 1.8450928818276882 9.401391506195068 1.5062377452850342 2.6341071128845215 0.43599578018695123 1.72868812084198 24.955042455555926 74.51266954444407 12.505884445039008 44.088171554961 38.475335677122004 172.697564322878 DOWN 0.4 0.6 0.0 GO:0019218 7 regulation of steroid metabolic process 46 49 6 6 4 6 4 4 92 45 2406 0.96479 0.11073 0.11073 8.16 78968;65030;25427;25649 srebf1;ephx2;cyp51;apoa2 SREBF1_32750;EPHX2_33282;CYP51_8429;APOA2_33095 31.585582499999997 23.821174999999997 3.54778 33.70880329737656 23.790169335752402 25.744264313689232 20.9409525 17.075085 1.51564 22.804311418044577 16.544893836072575 18.98364425949701 64.34038749999999 38.71235 8.55785 74.82307886178764 42.309098563500534 48.816658193978334 1.5 23.821174999999997 41.2009;6.44145;75.1522;3.54778 31.4864;2.66377;48.098;1.51564 60.0774;17.3473;171.379;8.55785 3 1 3 78968;65030;25649 SREBF1_32750;EPHX2_33282;APOA2_33095 17.063376666666667 6.44145 20.95371938386198 11.888603333333334 2.66377 16.981895543938354 28.66085 17.3473 27.560176310257887 41.2009;6.44145;3.54778 31.4864;2.66377;1.51564 60.0774;17.3473;8.55785 1 25427 CYP51_8429 75.1522 75.1522 48.098 48.098 171.379 171.379 75.1522 48.098 171.379 0 Exp 2,1(0.25);Exp 4,1(0.25);Hill,1(0.25);Linear,1(0.25) 1.891625470072367 7.646374464035034 1.633623480796814 2.3739430904388428 0.3293360545514718 1.8194039463996887 -1.4490447314290265 64.62020973142903 -1.407272689683687 43.28917768968369 -8.986229784551881 137.6670047845519 UP 0.75 0.25 0.0 GO:0033044 7 regulation of chromosome organization 75 76 3 3 3 3 3 3 93 73 2378 0.67878 0.55267 0.76263 3.95 360243;78968;291234 top2a;srebf1;mki67 TOP2A_10059;SREBF1_32750;MKI67_9232 48.646933333333344 49.7822 41.2009 6.94830982062059 46.78458949661736 7.306341969248797 28.661833333333334 31.4864 18.8326 8.765197085253321 29.08182633872262 7.80044440753383 120.23903333333332 82.1147 60.0774 85.82836990484753 107.01411612200435 82.64863671692967 54.9577;41.2009;49.7822 18.8326;31.4864;35.6665 218.525;60.0774;82.1147 1 2 1 78968 SREBF1_32750 41.2009 41.2009 31.4864 31.4864 60.0774 60.0774 41.2009 31.4864 60.0774 2 360243;291234 TOP2A_10059;MKI67_9232 52.36995 52.36995 3.659631146030959 27.24955 27.24955 11.903364843816222 150.31985 150.31985 96.45664815369132 54.9577;49.7822 18.8326;35.6665 218.525;82.1147 0 Exp 2,2(0.67);Linear,1(0.34) 1.9912272707047194 6.0042877197265625 1.8061060905456543 2.285626173019409 0.251811019322205 1.912555456161499 40.78418058445076 56.509686082215914 18.743079095857922 38.580587570808746 23.11508969473917 217.36297697192748 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:1903047 4 mitotic cell cycle process 136 146 14 14 11 14 11 11 85 135 2316 0.99239 0.019476 0.022569 7.53 257644;360243;308761;304951;316273;293502;303575;306575;64515;362485;114494 zwint;top2a;prc1;nuf2;mcm3;kif22;kif18b;ckap2;cdc20;ccne2;ccna2 ZWINT_10214;TOP2A_10059;PRC1_9556;NUF2_33136;MCM3_9207;KIF22_8963;KIF18B_32882;CKAP2_8324;CDC20_8255;CCNE2_8227;CCNA2_8221 62.247881818181874 64.2131 5.73955E-13 25.229889129792635 63.681273395109656 20.042655861681254 37.792690909090965 43.1133 5.73955E-13 15.667471486072815 39.348249430166945 12.53650789810002 162.62598181818188 131.93 5.73957E-13 113.570259428442 157.91980375831164 100.95614035252295 6.5 69.9499 59.0663;54.9577;80.3005;5.73955E-13;54.0045;73.9175;65.9823;64.2131;101.569;77.8893;52.8265 40.5797;18.8326;50.2731;5.73955E-13;33.259;47.5608;43.9552;43.1133;51.5499;49.2672;37.3288 108.188;218.525;198.961;5.73957E-13;111.753;165.416;131.93;125.437;453.17;185.461;90.0448 1 10 1 257644 ZWINT_10214 59.0663 59.0663 40.5797 40.5797 108.188 108.188 59.0663 40.5797 108.188 10 360243;308761;304951;316273;293502;303575;306575;64515;362485;114494 TOP2A_10059;PRC1_9556;NUF2_33136;MCM3_9207;KIF22_8963;KIF18B_32882;CKAP2_8324;CDC20_8255;CCNE2_8227;CCNA2_8221 62.56604000000006 65.0977 26.571367935898238 37.51399000000006 43.53425 16.486197816587715 168.0697800000001 148.673 118.19108587159269 54.9577;80.3005;5.73955E-13;54.0045;73.9175;65.9823;64.2131;101.569;77.8893;52.8265 18.8326;50.2731;5.73955E-13;33.259;47.5608;43.9552;43.1133;51.5499;49.2672;37.3288 218.525;198.961;5.73957E-13;111.753;165.416;131.93;125.437;453.17;185.461;90.0448 0 Exp 2,3(0.28);Hill,1(0.1);Linear,7(0.64) 1.8380857274402238 20.500837326049805 1.5293418169021606 2.6341071128845215 0.3428679875559247 1.7985904216766357 47.33797013984137 77.15779349652237 28.533806937047775 47.05157488113416 95.51024743452452 229.74171620183927 DOWN 0.09090909090909091 0.9090909090909091 0.0 GO:0031399 7 regulation of protein modification process 444 469 19 19 12 18 12 12 84 457 1994 0.077865 0.95685 0.14067 2.56 78968;24679;24484;24471;29455;299626;58868;64515;25599;362485;114494;81633 srebf1;prkar2b;igfbp3;hspb1;gdf15;gadd45b;fzd1;cdc20;cd74;ccne2;ccna2;acta2 SREBF1_32750;PRKAR2B_33052;IGFBP3_8881;HSPB1_8847;GDF15_33113;GADD45B_8679;FZD1_8671;CDC20_8255;CD74_8252;CCNE2_8227;CCNA2_8221;ACTA2_33040 63.270641666666656 52.69915 21.3654 30.1770145549242 63.85417824086735 27.989526445056438 41.17599166666667 37.2603 13.6792 17.091290962542534 42.06833744430326 16.02991815420811 129.52801666666667 96.8074 26.3528 110.36650309893383 125.50882152267279 106.20401829572832 41.2009;108.746;50.946;41.6322;21.3654;52.5718;25.231;101.569;94.9138;77.8893;52.8265;90.3558 31.4864;59.3814;36.3081;30.9494;17.8875;37.1918;13.6792;51.5499;58.8146;49.2672;37.3288;70.2676 60.0774;147.467;85.0816;63.3196;26.3528;89.36;131.659;453.17;118.773;185.461;90.0448;103.57 7 5 7 78968;24679;24471;29455;299626;58868;25599 SREBF1_32750;PRKAR2B_33052;HSPB1_8847;GDF15_33113;GADD45B_8679;FZD1_8671;CD74_8252 55.09444285714285 41.6322 33.848118070081696 35.62718571428571 31.4864 17.98056917493888 91.00125714285714 89.36 43.81281717088648 41.2009;108.746;41.6322;21.3654;52.5718;25.231;94.9138 31.4864;59.3814;30.9494;17.8875;37.1918;13.6792;58.8146 60.0774;147.467;63.3196;26.3528;89.36;131.659;118.773 5 24484;64515;362485;114494;81633 IGFBP3_8881;CDC20_8255;CCNE2_8227;CCNA2_8221;ACTA2_33040 74.71732 77.8893 22.471759429715316 48.944320000000005 49.2672 13.749272065713148 183.46548 103.57 156.15265706068533 50.946;101.569;77.8893;52.8265;90.3558 36.3081;51.5499;49.2672;37.3288;70.2676 85.0816;453.17;185.461;90.0448;103.57 0 Exp 2,3(0.25);Linear,5(0.42);Poly 2,3(0.25);Power,1(0.09) 1.8638988767901257 23.90156626701355 1.5124053955078125 5.015069484710693 0.9790331691989268 1.6392671465873718 46.196388339574426 80.3448949937589 31.505683457404963 50.84629987592837 67.0822889984533 191.97374433488005 CONFLICT 0.5833333333333334 0.4166666666666667 0.0 GO:1903531 6 negative regulation of secretion by cell 58 60 7 7 6 7 6 6 90 54 2397 0.99348 0.02372 0.02372 10.0 78968;309607;25664;24484;25427;25649 srebf1;rt1-ce5;pparg;igfbp3;cyp51;apoa2 SREBF1_32750;RT1-CE5_32445;PPARG_32510;IGFBP3_8881;CYP51_8429;APOA2_33095 25664(0.0441) 47.64296333333334 52.8833 3.54778 24.341354325264355 44.60279621946824 22.134924425631834 31.316990000000004 33.89725 1.51564 16.58570427940277 30.0065558767917 15.657462101359075 95.66280833333333 93.0693 8.55785 59.073489693130675 84.59318756134077 51.45687648428748 2.0 50.946 5.0 75.1522 41.2009;54.8206;60.1903;50.946;75.1522;3.54778 31.4864;26.5902;43.9036;36.3081;48.098;1.51564 60.0774;147.824;101.057;85.0816;171.379;8.55785 3 3 3 78968;25664;25649 SREBF1_32750;PPARG_32510;APOA2_33095 34.97966 41.2009 28.829180327244824 25.635213333333336 31.4864 21.791330324157197 56.564083333333336 60.0774 46.34954943881152 41.2009;60.1903;3.54778 31.4864;43.9036;1.51564 60.0774;101.057;8.55785 3 309607;24484;25427 RT1-CE5_32445;IGFBP3_8881;CYP51_8429 60.30626666666666 54.8206 13.002093435033238 36.99876666666667 36.3081 10.770521368222306 134.76153333333332 147.824 44.60696513161749 54.8206;50.946;75.1522 26.5902;36.3081;48.098 147.824;85.0816;171.379 0 Exp 2,3(0.5);Hill,1(0.17);Linear,2(0.34) 1.7255029448116144 10.381955623626709 1.5239794254302979 1.912555456161499 0.1406788556193302 1.7321282625198364 28.16582340323923 67.12010326342744 18.04566258031748 44.58831741968251 48.394172022581074 142.9314446440856 CONFLICT 0.5 0.5 0.0 GO:0032731 8 positive regulation of interleukin-1 beta production 22 23 2 2 2 2 2 2 94 21 2430 0.94677 0.21415 0.21415 8.7 24614;24471 orm1;hspb1 ORM1_9400;HSPB1_8847 32.942049999999995 32.942049999999995 24.2519 12.289727989056566 31.628578900095704 12.148539063790045 25.33135 25.33135 19.7133 7.945122504090176 24.482210881248623 7.853846008104054 47.3388 47.3388 31.358 22.600264097571962 44.92338496650225 22.34062393291439 0.5 32.942049999999995 24.2519;41.6322 19.7133;30.9494 31.358;63.3196 2 0 2 24614;24471 ORM1_9400;HSPB1_8847 32.942049999999995 32.942049999999995 12.289727989056566 25.33135 25.33135 7.945122504090176 47.3388 47.3388 22.600264097571962 24.2519;41.6322 19.7133;30.9494 31.358;63.3196 0 0 Exp 2,1(0.5);Linear,1(0.5) 2.5731074431466716 5.4318108558654785 1.8468482494354248 3.5849626064300537 1.2290324483085977 2.7159054279327393 15.909355999999999 49.97474399999999 14.319972 36.342728 16.016432000000002 78.661168 UP 1.0 0.0 0.0 GO:0017144 4 drug metabolic process 142 165 16 16 15 16 15 15 81 150 2301 0.99968 0.0010101 0.0010101 9.09 286954;360268;64305;24950;114027;50549;266682;65210;25086;24303;499353;171521;29277;24894;25612 ugt2b1;sult1e1;sult1b1;srd5a1;dao;cyp4a1;cyp3a2;cyp2j4;cyp2e1;cyp2d3;cyp2c24;cyp2c13;cyp2c11;cyp2a1;asns UGT2B10_33303,UGT2B1_33224;SULT1E1_32446;SULT1B1_32942;SRD5A1_32503;DAO_8437;CYP4A1_33111;CYP3A2_32374;CYP2J4_32580;CYP2E1_8421;CYP2D3_8420;CYP2C24_32875;CYP2C13_8419;CYP2C11_32593;CYP2A1_32717;ASNS_8091 30.777170666666663 23.208 6.1336 27.296044987703283 35.396766573420784 30.012577461745163 20.935754999999997 18.6955 2.43617 17.381977075069642 23.548277614057227 18.70782352851643 44.18432333333333 35.0879 15.8079 29.588445469780368 50.46952165690758 31.710040913497696 7.5 23.22825 12.54415;59.2729;15.4629;29.2087;6.1336;23.208;23.2485;16.3155;7.89174;12.8059;58.9435;104.635;54.426;9.37187;28.1893 7.348245;45.3114;7.69418;22.9308;2.43617;18.863;18.6955;8.2378;4.16797;8.8664;48.1505;49.2461;43.9518;4.95906;23.1774 25.495849999999997;91.5578;35.0879;39.9852;16.2027;29.9853;30.5145;36.8422;15.8079;22.6004;80.4167;108.327;74.8861;19.1079;35.9474 15 1 14 286954;360268;64305;114027;50549;266682;65210;25086;24303;499353;171521;29277;24894;25612 UGT2B10_33303,UGT2B1_33224;SULT1E1_32446;SULT1B1_32942;DAO_8437;CYP4A1_33111;CYP3A2_32374;CYP2J4_32580;CYP2E1_8421;CYP2D3_8420;CYP2C24_32875;CYP2C13_8419;CYP2C11_32593;CYP2A1_32717;ASNS_8091 30.88920428571429 19.76175 28.32286543781671 20.793251785714283 13.78095 18.029034859739834 44.48426071428571 32.8012 30.681707609221508 12.54415;59.2729;15.4629;6.1336;23.208;23.2485;16.3155;7.89174;12.8059;58.9435;104.635;54.426;9.37187;28.1893 7.348245;45.3114;7.69418;2.43617;18.863;18.6955;8.2378;4.16797;8.8664;48.1505;49.2461;43.9518;4.95906;23.1774 25.495849999999997;91.5578;35.0879;16.2027;29.9853;30.5145;36.8422;15.8079;22.6004;80.4167;108.327;74.8861;19.1079;35.9474 1 24950 SRD5A1_32503 29.2087 29.2087 22.9308 22.9308 39.9852 39.9852 29.2087 22.9308 39.9852 0 Exp 2,5(0.32);Exp 4,5(0.32);Hill,1(0.07);Linear,2(0.13);Poly 2,2(0.13);Power,1(0.07) 2.166790908978548 36.1046746969223 1.5310101509094238 3.7662253379821777 0.6900282157797136 1.9969033002853394 16.963465986452107 44.59087534688121 12.13926092250857 29.73224907749143 29.210503944835576 59.158142721831084 UP 0.9333333333333333 0.06666666666666667 0.0 GO:0060416 6 response to growth hormone 18 18 4 4 4 4 4 4 92 14 2437 0.9996 0.0038618 0.0038618 22.22 286954;24950;24614;24484 ugt2b1;srd5a1;orm1;igfbp3 UGT2B10_33303,UGT2B1_33224;SRD5A1_32503;ORM1_9400;IGFBP3_8881 29.2376875 26.7303 12.54415 16.07051070679745 28.10069907348533 15.487572320957776 21.57511125 21.32205 7.348245 11.899144421911448 20.872485156689983 11.475451857244945 45.48016249999999 35.6716 25.495849999999997 27.06336197837017 43.240197120537744 26.18477531341074 0.0 12.54415 0.5 18.398025 12.54415;29.2087;24.2519;50.946 7.348245;22.9308;19.7133;36.3081 25.495849999999997;39.9852;31.358;85.0816 3 2 2 286954;24614 UGT2B10_33303,UGT2B1_33224;ORM1_9400 18.398025 18.398025 8.278629417436797 13.530772500000001 13.530772500000001 8.743414240244622 28.426924999999997 28.426924999999997 4.145166017332751 12.54415;24.2519 7.348245;19.7133 25.495849999999997;31.358 2 24950;24484 SRD5A1_32503;IGFBP3_8881 40.077349999999996 40.077349999999996 15.370592234686345 29.61945 29.61945 9.459179543966815 62.5334 62.5334 31.887970247101 29.2087;50.946 22.9308;36.3081 39.9852;85.0816 0 Exp 2,1(0.2);Exp 4,1(0.2);Linear,2(0.4);Poly 2,1(0.2) 2.0290403312904273 10.639367818832397 1.635288953781128 3.5849626064300537 0.8227043737562392 1.7380040884017944 13.488587007338497 44.986787992661505 9.913949716526787 33.23627278347322 18.958067761197245 72.00225723880276 CONFLICT 0.5 0.5 0.0 GO:0032787 7 monocarboxylic acid metabolic process 180 207 37 37 33 37 33 33 63 174 2277 1.0 6.108E-14 6.108E-14 15.94 29142;286954;24679;25664;24552;364975;65030;25315;171142;291075;29740;64526;117543;50549;65210;25086;24303;499353;171521;29277;24894;311849;25413;25599;25612;502970;24763;50681;681337;314304;192272;50559;170465 vnn1;ugt2b1;prkar2b;pparg;me1;gcdh;ephx2;ephx1;ehhadh;eci2;eci1;ech1;decr1;cyp4a1;cyp2j4;cyp2e1;cyp2d3;cyp2c24;cyp2c13;cyp2c11;cyp2a1;crat;cpt2;cd74;asns;angptl3;acsm3;acox1;acot4;acot3;acot2;acot1;acaa2 VNN1_10157;UGT2B10_33303,UGT2B1_33224;PRKAR2B_33052;PPARG_32510;ME1_9215;GCDH_8693;EPHX2_33282;EPHX1_8567;EHHADH_8534;ECI2_8521;ECI1_8520;ECH1_8516;DECR1_8458;CYP4A1_33111;CYP2J4_32580;CYP2E1_8421;CYP2D3_8420;CYP2C24_32875;CYP2C13_8419;CYP2C11_32593;CYP2A1_32717;CRAT_8375;CPT2_8374;CD74_8252;ASNS_8091;ANGPTL3_8045;ACSM3_7976;ACOX1_7973;ACOT4_7971;ACOT3_7970;ACOT2_7969;ACOT1_7968;ACAA2_7955 25664(0.0441) 33.81587333333334 23.208 6.44145 29.20586771648129 37.43532948586894 31.010512528478944 22.81039712121212 18.863 1.97988 17.71233218465876 24.65029172511026 18.826443567336028 48.88966515151516 31.3726 11.8779 36.443036371641185 54.64502138366816 38.03994301647528 9.5 12.675025 19.5 29.6986 20.7328;12.54415;108.746;60.1903;49.3339;15.9021;6.44145;34.0134;7.29984;8.72912;11.7653;9.87438;21.6199;23.208;16.3155;7.89174;12.8059;58.9435;104.635;54.426;9.37187;8.98517;31.2175;94.9138;28.1893;58.0729;52.2057;23.8014;12.3157;30.8838;13.6362;28.5134;78.3988 16.8296;7.348245;59.3814;43.9036;35.4173;10.4227;2.66377;26.1579;5.26587;5.10151;8.40998;6.59127;17.4928;18.863;8.2378;4.16797;8.8664;48.1505;49.2461;43.9518;4.95906;1.97988;24.8356;58.8146;23.1774;40.0757;42.2655;19.0993;6.70485;24.6874;11.3249;24.741;43.6084 26.7838;25.495849999999997;147.467;101.057;80.9924;31.2818;17.3473;48.3681;11.8779;17.7951;18.8402;19.44;28.0829;29.9853;36.8422;15.8079;22.6004;80.4167;108.327;74.8861;19.1079;31.3726;42.0237;118.773;35.9474;105.112;71.1126;31.3543;24.3993;41.2585;16.9658;33.4642;98.7727 33 1 32 29142;286954;24679;25664;24552;364975;65030;25315;171142;291075;29740;64526;117543;50549;65210;25086;24303;499353;171521;29277;24894;311849;25413;25599;25612;502970;24763;50681;681337;314304;192272;50559 VNN1_10157;UGT2B10_33303,UGT2B1_33224;PRKAR2B_33052;PPARG_32510;ME1_9215;GCDH_8693;EPHX2_33282;EPHX1_8567;EHHADH_8534;ECI2_8521;ECI1_8520;ECH1_8516;DECR1_8458;CYP4A1_33111;CYP2J4_32580;CYP2E1_8421;CYP2D3_8420;CYP2C24_32875;CYP2C13_8419;CYP2C11_32593;CYP2A1_32717;CRAT_8375;CPT2_8374;CD74_8252;ASNS_8091;ANGPTL3_8045;ACSM3_7976;ACOX1_7973;ACOT4_7971;ACOT3_7970;ACOT2_7969;ACOT1_7968 32.422656875 22.41395 28.537296294026767 22.160459531249998 18.1779 17.591402260137613 47.3308203125 31.36345 35.89094580872474 20.7328;12.54415;108.746;60.1903;49.3339;15.9021;6.44145;34.0134;7.29984;8.72912;11.7653;9.87438;21.6199;23.208;16.3155;7.89174;12.8059;58.9435;104.635;54.426;9.37187;8.98517;31.2175;94.9138;28.1893;58.0729;52.2057;23.8014;12.3157;30.8838;13.6362;28.5134 16.8296;7.348245;59.3814;43.9036;35.4173;10.4227;2.66377;26.1579;5.26587;5.10151;8.40998;6.59127;17.4928;18.863;8.2378;4.16797;8.8664;48.1505;49.2461;43.9518;4.95906;1.97988;24.8356;58.8146;23.1774;40.0757;42.2655;19.0993;6.70485;24.6874;11.3249;24.741 26.7838;25.495849999999997;147.467;101.057;80.9924;31.2818;17.3473;48.3681;11.8779;17.7951;18.8402;19.44;28.0829;29.9853;36.8422;15.8079;22.6004;80.4167;108.327;74.8861;19.1079;31.3726;42.0237;118.773;35.9474;105.112;71.1126;31.3543;24.3993;41.2585;16.9658;33.4642 1 170465 ACAA2_7955 78.3988 78.3988 43.6084 43.6084 98.7727 98.7727 78.3988 43.6084 98.7727 0 Exp 2,9(0.27);Exp 4,5(0.15);Hill,5(0.15);Linear,7(0.21);Poly 2,6(0.18);Power,2(0.06) 2.3817311940333465 127.02534770965576 1.5239794254302979 50.888092041015625 8.377410621004781 1.9086998105049133 23.851058908548314 43.78068775811835 16.767087435512558 28.853706806911674 36.45558519044741 61.323745112582884 UP 0.9696969696969697 0.030303030303030304 0.0 GO:0031349 6 positive regulation of defense response 74 79 3 3 3 3 3 3 93 76 2375 0.65261 0.57943 1.0 3.8 309607;63868;25599 rt1-ce5;hspd1;cd74 RT1-CE5_32445;HSPD1_8849;CD74_8252 61.39329999999999 54.8206 34.4455 30.765307006269275 65.56016145049807 31.442183010296677 37.36516666666667 26.6907 26.5902 18.57582212994442 39.820162080707455 19.380198383887038 105.02756666666669 118.773 48.4857 51.07570033649399 108.19975135698314 47.89955083859421 54.8206;34.4455;94.9138 26.5902;26.6907;58.8146 147.824;48.4857;118.773 2 1 2 63868;25599 HSPD1_8849;CD74_8252 64.67965 64.67965 42.757544976822516 42.75265 42.75265 22.715027528158515 83.62935 83.62935 49.7006264612932 34.4455;94.9138 26.6907;58.8146 48.4857;118.773 1 309607 RT1-CE5_32445 54.8206 54.8206 26.5902 26.5902 147.824 147.824 54.8206 26.5902 147.824 0 Exp 2,2(0.67);Poly 2,1(0.34) 1.7180518634246613 5.161044478416443 1.6557694673538208 1.8475407361984253 0.11015638337309705 1.6577342748641968 26.579077767728776 96.20752223227122 16.344645088668297 58.38568824466503 47.229970763552664 162.82516256978067 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0031032 6 actomyosin structure organization 33 36 2 2 2 2 2 2 94 34 2417 0.84797 0.39639 0.39639 5.56 54133;25626 pdlim1;krt8 PDLIM1_9452;KRT8_8978 68.0343 68.0343 67.1147 1.300510791958002 68.033738172043 1.3005105492467777 46.28965 46.28965 45.3374 1.3466848647699836 46.290231775415435 1.3466846134398998 133.746 133.746 123.914 13.904547745252074 133.73999315738027 13.904545150262221 0.5 68.0343 67.1147;68.9539 47.2419;45.3374 123.914;143.578 2 0 2 54133;25626 PDLIM1_9452;KRT8_8978 68.0343 68.0343 1.300510791958002 46.28965 46.28965 1.3466848647699836 133.746 133.746 13.904547745252074 67.1147;68.9539 47.2419;45.3374 123.914;143.578 0 0 Exp 2,1(0.5);Linear,1(0.5) 1.6135463267537642 3.2273999452590942 1.5914322137832642 1.63596773147583 0.03149136656406683 1.6136999726295471 66.231884 69.83671600000001 44.42324 48.156060000000004 114.47528000000001 153.01672000000002 UP 1.0 0.0 0.0 GO:0051338 5 regulation of transferase activity 261 279 14 14 9 13 9 9 87 270 2181 0.38147 0.74172 0.73962 3.23 24679;25664;24471;29455;299626;64515;25599;362485;114494 prkar2b;pparg;hspb1;gdf15;gadd45b;cdc20;cd74;ccne2;ccna2 PRKAR2B_33052;PPARG_32510;HSPB1_8847;GDF15_33113;GADD45B_8679;CDC20_8255;CD74_8252;CCNE2_8227;CCNA2_8221 25664(0.0441) 67.96714444444444 60.1903 21.3654 29.598475704253396 69.59295102595692 25.515120241777986 42.91935555555555 43.9036 17.8875 13.57083591512618 44.599296658736556 11.238837266148701 141.66724444444446 101.057 26.3528 125.496780023783 139.43169297761165 118.75000490390583 108.746;60.1903;41.6322;21.3654;52.5718;101.569;94.9138;77.8893;52.8265 59.3814;43.9036;30.9494;17.8875;37.1918;51.5499;58.8146;49.2672;37.3288 147.467;101.057;63.3196;26.3528;89.36;453.17;118.773;185.461;90.0448 6 3 6 24679;25664;24471;29455;299626;25599 PRKAR2B_33052;PPARG_32510;HSPB1_8847;GDF15_33113;GADD45B_8679;CD74_8252 63.23658333333333 56.38105 32.91660942359749 41.35471666666666 40.5477 16.202570119881198 91.05489999999999 95.2085 42.44794787722962 108.746;60.1903;41.6322;21.3654;52.5718;94.9138 59.3814;43.9036;30.9494;17.8875;37.1918;58.8146 147.467;101.057;63.3196;26.3528;89.36;118.773 3 64515;362485;114494 CDC20_8255;CCNE2_8227;CCNA2_8221 77.42826666666667 77.8893 24.37452031042526 46.048633333333335 49.2672 7.637362099791563 242.89193333333333 185.461 188.25172455096754 101.569;77.8893;52.8265 51.5499;49.2672;37.3288 453.17;185.461;90.0448 0 Exp 2,3(0.34);Linear,4(0.45);Poly 2,1(0.12);Power,1(0.12) 1.9066430931979217 18.66195583343506 1.5239794254302979 5.015069484710693 1.1318537775918383 1.6208000183105469 48.629473650998904 87.30481523788998 34.053076091006474 51.785635020104635 59.67601482890622 223.65847405998267 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0070542 5 response to fatty acid 60 63 5 5 4 5 4 4 92 59 2392 0.91371 0.21166 0.29787 6.35 78968;25664;24471;25413 srebf1;pparg;hspb1;cpt2 SREBF1_32750;PPARG_32510;HSPB1_8847;CPT2_8374 25664(0.0441) 43.560224999999996 41.41655 31.2175 12.085610587078353 45.80798695732291 11.930468492984858 32.79375 31.2179 24.8356 7.997326832344241 34.307078713053734 7.920048872378091 66.619425 61.698499999999996 42.0237 24.79639218574279 71.01989521633375 24.71565733654962 2.5 50.911249999999995 41.2009;60.1903;41.6322;31.2175 31.4864;43.9036;30.9494;24.8356 60.0774;101.057;63.3196;42.0237 4 0 4 78968;25664;24471;25413 SREBF1_32750;PPARG_32510;HSPB1_8847;CPT2_8374 43.560224999999996 41.41655 12.085610587078353 32.79375 31.2179 7.997326832344241 66.619425 61.698499999999996 24.79639218574279 41.2009;60.1903;41.6322;31.2175 31.4864;43.9036;30.9494;24.8356 60.0774;101.057;63.3196;42.0237 0 0 Exp 2,3(0.75);Linear,1(0.25) 1.7828616290350987 7.160305023193359 1.5239794254302979 1.912555456161499 0.17941934257596492 1.8618850708007812 31.716326624663232 55.40412337533677 24.956369704302638 40.63113029569737 42.31896065797204 90.91988934202794 UP 1.0 0.0 0.0 GO:0009966 5 regulation of signal transduction 594 626 21 21 15 20 15 15 81 611 1840 0.021548 0.989 0.039609 2.4 29142;365813;24679;25664;338475;24484;25685;24471;29455;299626;58868;65210;25599;81633;170465 vnn1;trim59;prkar2b;pparg;nrep;igfbp3;igfbp1;hspb1;gdf15;gadd45b;fzd1;cyp2j4;cd74;acta2;acaa2 VNN1_10157;TRIM59_10085;PRKAR2B_33052;PPARG_32510;NREP_9364;IGFBP3_8881;IGFBP1_32306;HSPB1_8847;GDF15_33113;GADD45B_8679;FZD1_8671;CYP2J4_32580;CD74_8252;ACTA2_33040;ACAA2_7955 25664(0.0441) 59.05164666666666 56.1278 16.3155 30.56590682989947 59.09345524145215 27.407250361682088 38.07737999999999 37.1918 8.2378 18.516839522028906 38.26727208198336 17.66000827140699 111.08498 101.057 26.3528 79.43122200509788 102.52378939841685 51.523068425030104 20.7328;56.1278;108.746;60.1903;69.4104;50.946;98.8371;41.6322;21.3654;52.5718;25.231;16.3155;94.9138;90.3558;78.3988 16.8296;33.6269;59.3814;43.9036;43.1468;36.3081;57.328;30.9494;17.8875;37.1918;13.6792;8.2378;58.8146;70.2676;43.6084 26.7838;121.883;147.467;101.057;157.944;85.0816;357.409;63.3196;26.3528;89.36;131.659;36.8422;118.773;103.57;98.7727 10 5 10 29142;24679;25664;25685;24471;29455;299626;58868;65210;25599 VNN1_10157;PRKAR2B_33052;PPARG_32510;IGFBP1_32306;HSPB1_8847;GDF15_33113;GADD45B_8679;FZD1_8671;CYP2J4_32580;CD74_8252 54.05359000000001 47.102000000000004 35.42476068199409 34.42029 34.0706 19.86354891847263 109.90234000000001 95.2085 97.25103376172866 20.7328;108.746;60.1903;98.8371;41.6322;21.3654;52.5718;25.231;16.3155;94.9138 16.8296;59.3814;43.9036;57.328;30.9494;17.8875;37.1918;13.6792;8.2378;58.8146 26.7838;147.467;101.057;357.409;63.3196;26.3528;89.36;131.659;36.8422;118.773 5 365813;338475;24484;81633;170465 TRIM59_10085;NREP_9364;IGFBP3_8881;ACTA2_33040;ACAA2_7955 69.04776 69.4104 16.095069951634272 45.391560000000005 43.1468 14.559811499569621 113.45026 103.57 28.14531567824383 56.1278;69.4104;50.946;90.3558;78.3988 33.6269;43.1468;36.3081;70.2676;43.6084 121.883;157.944;85.0816;103.57;98.7727 0 Exp 2,4(0.27);Exp 4,1(0.07);Linear,5(0.34);Poly 2,4(0.27);Power,1(0.07) 1.9711380695935479 32.12105405330658 1.5124053955078125 5.015069484710693 1.105764989089179 1.72868812084198 43.58316357978004 74.52012975355328 28.706566283820138 47.44819371617986 70.88723546736595 151.282724532634 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0031669 5 cellular response to nutrient levels 87 92 6 6 5 6 5 5 91 87 2364 0.86953 0.26445 0.39394 5.43 78968;24950;25664;58868;25612 srebf1;srd5a1;pparg;fzd1;asns SREBF1_32750;SRD5A1_32503;PPARG_32510;FZD1_8671;ASNS_8091 25664(0.0441) 36.80404 29.2087 25.231 14.422965406531361 41.23910025829115 15.163100323351243 27.035479999999996 23.1774 13.6792 11.340938627468194 30.265687646795467 11.803035246527699 73.7452 60.0774 35.9474 41.397954935479596 78.21594159864999 37.002221053542186 3.5 50.6956 41.2009;29.2087;60.1903;25.231;28.1893 31.4864;22.9308;43.9036;13.6792;23.1774 60.0774;39.9852;101.057;131.659;35.9474 4 1 4 78968;25664;58868;25612 SREBF1_32750;PPARG_32510;FZD1_8671;ASNS_8091 38.702875 34.6951 15.916199685933204 28.06165 27.331899999999997 12.824547534968492 82.1852 80.5672 42.54601701436537 41.2009;60.1903;25.231;28.1893 31.4864;43.9036;13.6792;23.1774 60.0774;101.057;131.659;35.9474 1 24950 SRD5A1_32503 29.2087 29.2087 22.9308 22.9308 39.9852 39.9852 29.2087 22.9308 39.9852 0 Exp 2,3(0.6);Linear,1(0.2);Poly 2,1(0.2) 1.9479859970755635 10.161198616027832 1.5124053955078125 3.2609751224517822 0.7175000382696848 1.912555456161499 24.161753414236266 49.446326585763735 17.094708997728567 36.97625100227143 37.45829258483952 110.03210741516048 UP 0.8 0.2 0.0 GO:0048291 12 isotype switching to IgG isotypes 1 1 1 1 1 1 1 1 95 0 2451 1.0 0.037691 0.037691 100.0 63868 hspd1 HSPD1_8849 34.4455 34.4455 34.4455 34.4455 26.6907 26.6907 26.6907 26.6907 48.4857 48.4857 48.4857 48.4857 0.0 34.4455 0.0 34.4455 34.4455 26.6907 48.4857 1 0 1 63868 HSPD1_8849 34.4455 34.4455 26.6907 26.6907 48.4857 48.4857 34.4455 26.6907 48.4857 0 0 Exp 2,1(1) 1.6557694673538208 1.6557694673538208 1.6557694673538208 1.6557694673538208 0.0 1.6557694673538208 34.4455 34.4455 26.6907 26.6907 48.4857 48.4857 UP 1.0 0.0 0.0 GO:0010628 7 positive regulation of gene expression 455 488 20 19 18 20 17 17 79 471 1980 0.41609 0.68475 0.79235 3.48 360243;78968;309607;25664;24614;65035;259241;63868;24471;58868;65030;65210;306575;25599;114494;25649;81633 top2a;srebf1;rt1-ce5;pparg;orm1;nr1i3;nr1d2;hspd1;hspb1;fzd1;ephx2;cyp2j4;ckap2;cd74;ccna2;apoa2;acta2 TOP2A_10059;SREBF1_32750;RT1-CE5_32445;PPARG_32510;ORM1_9400;NR1I3_32602;NR1D2_9358;HSPD1_8849;HSPB1_8847;FZD1_8671;EPHX2_33282;CYP2J4_32580;CKAP2_8324;CD74_8252;CCNA2_8221;APOA2_33095;ACTA2_33040 25664(0.0441) 46.262495882352944 41.6322 3.54778 29.37650810227728 44.642442405683205 28.740088786029535 28.78208882352941 26.6907 1.51564 19.119002127363984 28.565819049842382 19.189014099286997 85.97516176470587 90.0448 8.55785 53.93815120224951 81.43376482936634 51.59858363193468 54.9577;41.2009;54.8206;60.1903;24.2519;22.095;99.0234;34.4455;41.6322;25.231;6.44145;16.3155;64.2131;94.9138;52.8265;3.54778;90.3558 18.8326;31.4864;26.5902;43.9036;19.7133;12.9529;42.5557;26.6907;30.9494;13.6792;2.66377;8.2378;43.1133;58.8146;37.3288;1.51564;70.2676 218.525;60.0774;147.824;101.057;31.358;55.8619;102.838;48.4857;63.3196;131.659;17.3473;36.8422;125.437;118.773;90.0448;8.55785;103.57 12 5 12 78968;25664;24614;65035;259241;63868;24471;58868;65030;65210;25599;25649 SREBF1_32750;PPARG_32510;ORM1_9400;NR1I3_32602;NR1D2_9358;HSPD1_8849;HSPB1_8847;FZD1_8671;EPHX2_33282;CYP2J4_32580;CD74_8252;APOA2_33095 39.10739416666666 29.838250000000002 31.239462745346042 24.430250833333332 23.201999999999998 17.883572256193656 64.68141250000001 57.96965 40.26049949655212 41.2009;60.1903;24.2519;22.095;99.0234;34.4455;41.6322;25.231;6.44145;16.3155;94.9138;3.54778 31.4864;43.9036;19.7133;12.9529;42.5557;26.6907;30.9494;13.6792;2.66377;8.2378;58.8146;1.51564 60.0774;101.057;31.358;55.8619;102.838;48.4857;63.3196;131.659;17.3473;36.8422;118.773;8.55785 5 360243;309607;306575;114494;81633 TOP2A_10059;RT1-CE5_32445;CKAP2_8324;CCNA2_8221;ACTA2_33040 63.43474 54.9577 15.683970214936013 39.2265 37.3288 19.734776434254343 137.08016 125.437 50.54579890780242 54.9577;54.8206;64.2131;52.8265;90.3558 18.8326;26.5902;43.1133;37.3288;70.2676 218.525;147.824;125.437;90.0448;103.57 0 Exp 2,6(0.36);Exp 4,2(0.12);Hill,1(0.06);Linear,3(0.18);Poly 2,4(0.24);Power,1(0.06) 1.9870340809329865 34.74051356315613 1.5124053955078125 3.5849626064300537 0.5414372305682736 1.8475407361984253 32.29779036457032 60.227201400135556 19.69349212670825 37.87068552035057 60.33459226302793 111.61573126638385 UP 0.7058823529411765 0.29411764705882354 0.0 GO:0048584 5 positive regulation of response to stimulus 502 537 11 11 8 10 8 8 88 529 1922 5.6215E-4 0.99983 0.0012404 1.49 309607;24484;63868;24471;29455;299626;25599;81633 rt1-ce5;igfbp3;hspd1;hspb1;gdf15;gadd45b;cd74;acta2 RT1-CE5_32445;IGFBP3_8881;HSPD1_8849;HSPB1_8847;GDF15_33113;GADD45B_8679;CD74_8252;ACTA2_33040 55.131387499999995 51.7589 21.3654 25.62878137264752 60.17546666886009 24.06394515424996 38.0874875 33.628750000000004 17.8875 17.688606027645314 40.76840129850189 16.571496941170956 85.34583749999999 87.2208 26.3528 39.08452881976039 93.71003464060891 34.002929175048386 54.8206;50.946;34.4455;41.6322;21.3654;52.5718;94.9138;90.3558 26.5902;36.3081;26.6907;30.9494;17.8875;37.1918;58.8146;70.2676 147.824;85.0816;48.4857;63.3196;26.3528;89.36;118.773;103.57 5 3 5 63868;24471;29455;299626;25599 HSPD1_8849;HSPB1_8847;GDF15_33113;GADD45B_8679;CD74_8252 48.98574 41.6322 28.065204583220122 34.306799999999996 30.9494 15.393391539066366 69.25822000000001 63.3196 35.92852229652645 34.4455;41.6322;21.3654;52.5718;94.9138 26.6907;30.9494;17.8875;37.1918;58.8146 48.4857;63.3196;26.3528;89.36;118.773 3 309607;24484;81633 RT1-CE5_32445;IGFBP3_8881;ACTA2_33040 65.37413333333333 54.8206 21.721323241767138 44.38863333333334 36.3081 22.932511460878693 112.15853333333332 103.57 32.24088038582898 54.8206;50.946;90.3558 26.5902;36.3081;70.2676 147.824;85.0816;103.57 0 Exp 2,3(0.38);Linear,3(0.38);Poly 2,2(0.25) 1.9427153926213903 16.914393305778503 1.5528020858764648 5.015069484710693 1.1769571947198485 1.6978691816329956 37.37154809989639 72.8912269001036 25.829908893552467 50.34506610644753 58.261640839425056 112.43003416057492 UP 0.625 0.375 0.0 GO:0050776 5 regulation of immune response 176 199 6 6 5 6 5 5 91 194 2257 0.2251 0.88288 0.43802 2.51 309607;25664;63868;25599;25649 rt1-ce5;pparg;hspd1;cd74;apoa2 RT1-CE5_32445;PPARG_32510;HSPD1_8849;CD74_8252;APOA2_33095 25664(0.0441) 49.583596 54.8206 3.54778 33.70168423318159 53.31075734809535 33.774497750821276 31.502948000000004 26.6907 1.51564 21.483912410255254 34.09849344531432 21.607199963197075 84.93951000000001 101.057 8.55785 55.95081737542356 88.88763786077357 53.219152743409566 54.8206;60.1903;34.4455;94.9138;3.54778 26.5902;43.9036;26.6907;58.8146;1.51564 147.824;101.057;48.4857;118.773;8.55785 4 1 4 25664;63868;25599;25649 PPARG_32510;HSPD1_8849;CD74_8252;APOA2_33095 48.274345 47.3179 38.76824867935228 32.731134999999995 35.29715 24.603963797639743 69.2183875 74.77135 50.26231857867239 60.1903;34.4455;94.9138;3.54778 43.9036;26.6907;58.8146;1.51564 101.057;48.4857;118.773;8.55785 1 309607 RT1-CE5_32445 54.8206 54.8206 26.5902 26.5902 147.824 147.824 54.8206 26.5902 147.824 0 Exp 2,3(0.6);Hill,1(0.2);Poly 2,1(0.2) 1.6789526319385872 8.41127634048462 1.5239794254302979 1.8475407361984253 0.11790786225598673 1.6577342748641968 20.04276729456227 79.12442470543773 12.671468479783012 50.33442752021699 35.896456229135595 133.9825637708644 UP 0.8 0.2 0.0 GO:0046890 6 regulation of lipid biosynthetic process 73 78 6 6 3 6 3 3 93 75 2376 0.66134 0.57062 1.0 3.85 78968;25427;25599 srebf1;cyp51;cd74 SREBF1_32750;CYP51_8429;CD74_8252 70.42229999999999 75.1522 41.2009 27.167036498484734 67.51783258487322 31.477080311742927 46.133 48.098 31.4864 13.769660401041113 44.81634592823377 15.994964682807531 116.74313333333332 118.773 60.0774 55.67855789847055 95.51992335625269 45.02666281491031 41.2009;75.1522;94.9138 31.4864;48.098;58.8146 60.0774;171.379;118.773 2 1 2 78968;25599 SREBF1_32750;CD74_8252 68.05735 68.05735 37.98075582719492 45.1505 45.1505 19.323955537622194 89.42519999999999 89.42519999999999 41.50405678581317 41.2009;94.9138 31.4864;58.8146 60.0774;118.773 1 25427 CYP51_8429 75.1522 75.1522 48.098 48.098 171.379 171.379 75.1522 48.098 171.379 0 Exp 2,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 1.730189373178243 5.20391321182251 1.633623480796814 1.912555456161499 0.1545521550098637 1.6577342748641968 39.67990416245031 101.16469583754967 30.55116240718599 61.714837592814014 53.73691376741997 179.74935289924667 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0019221 6 cytokine-mediated signaling pathway 83 85 3 3 2 2 2 2 94 83 2368 0.37009 0.83952 0.76989 2.35 25626;25599 krt8;cd74 KRT8_8978;CD74_8252 81.93385 81.93385 68.9539 18.35642132892463 81.83953755541872 18.355936759822352 52.076 52.076 45.3374 9.529819511407347 52.02703726600985 9.529567945156908 131.1755 131.1755 118.773 17.539783707332337 131.2656166871921 17.539320695664824 68.9539;94.9138 45.3374;58.8146 143.578;118.773 2 0 2 25626;25599 KRT8_8978;CD74_8252 81.93385 81.93385 18.35642132892463 52.076 52.076 9.529819511407347 131.1755 131.1755 17.539783707332337 68.9539;94.9138 45.3374;58.8146 143.578;118.773 0 0 Linear,1(0.5);Poly 2,1(0.5) 1.6242449713363813 3.249166488647461 1.5914322137832642 1.6577342748641968 0.04688263699697213 1.6245832443237305 56.49314800000002 107.374552 38.86834400000001 65.283656 106.86659999999999 155.4844 UP 1.0 0.0 0.0 GO:0097435 5 supramolecular fiber organization 101 107 3 3 2 2 2 2 94 105 2346 0.2215 0.91938 0.43508 1.87 54133;303575 pdlim1;kif18b PDLIM1_9452;KIF18B_32882 66.54849999999999 66.54849999999999 65.9823 0.8007277190170073 66.51987817971013 0.7997039844890815 45.59855 45.59855 43.9552 2.3240478577256005 45.51547746666666 2.3210765505281064 127.922 127.922 123.914 5.668167957991391 128.12460730434782 5.660921175961718 67.1147;65.9823 47.2419;43.9552 123.914;131.93 1 1 1 54133 PDLIM1_9452 67.1147 67.1147 47.2419 47.2419 123.914 123.914 67.1147 47.2419 123.914 1 303575 KIF18B_32882 65.9823 65.9823 43.9552 43.9552 131.93 131.93 65.9823 43.9552 131.93 0 Exp 2,1(0.5);Linear,1(0.5) 1.679030150181624 3.359193801879883 1.63596773147583 1.7232260704040527 0.06170096317122034 1.6795969009399414 65.43874799999999 67.65825199999999 42.377584 48.81951600000001 120.06631999999999 135.77768 CONFLICT 0.5 0.5 0.0 GO:0048519 4 negative regulation of biological process 1024 1094 45 44 33 44 32 32 64 1062 1389 0.032108 0.98062 0.058346 2.93 257644;29142;365813;360243;361604;78968;64159;84386;299270;309607;24679;25664;24614;65035;259241;24484;63868;24471;102551184;29455;299626;58868;25427;65210;306575;25599;25612;25649;155423;50559;170465;114628 zwint;vnn1;trim59;top2a;sytl2;srebf1;sptan1;slpi;serpina6;rt1-ce5;prkar2b;pparg;orm1;nr1i3;nr1d2;igfbp3;hspd1;hspb1;loc102551184;gdf15;gadd45b;fzd1;cyp51;cyp2j4;ckap2;cd74;asns;apoa2;anxa7;acot1;acaa2;abcg5 ZWINT_10214;VNN1_10157;TRIM59_10085;TOP2A_10059;SYTL2_32351;SREBF1_32750;SPTAN1_9932;SLPI_9890;SERPINA6_32325;RT1-CE5_32445;PRKAR2B_33052;PPARG_32510;ORM1_9400;NR1I3_32602;NR1D2_9358;IGFBP3_8881;HSPD1_8849;HSPB1_8847;HIST1H4A_32934;GDF15_33113;GADD45B_8679;FZD1_8671;CYP51_8429;CYP2J4_32580;CKAP2_8324;CD74_8252;ASNS_8091;APOA2_33095;ANXA7_8051;ACOT1_7968;ACAA2_7955;ABCG5_7947 25664(0.0441) 50.29834625 53.15735 3.54778 24.99014536461481 50.33912073917692 23.68484337404297 31.93437625 34.02105 1.51564 13.88069223062293 32.085461714563145 13.830286529839274 89.8002265625 91.02625 8.55785 48.329189132422 88.74207585400848 43.80340112088646 59.0663;20.7328;56.1278;54.9577;67.0093;41.2009;47.5519;53.7429;68.3847;54.8206;108.746;60.1903;24.2519;22.095;99.0234;50.946;34.4455;41.6322;58.3303;21.3654;52.5718;25.231;75.1522;16.3155;64.2131;94.9138;28.1893;3.54778;64.7676;28.5134;78.3988;33.1119 40.5797;16.8296;33.6269;18.8326;44.4373;31.4864;34.4152;37.8192;36.9679;26.5902;59.3814;43.9036;19.7133;12.9529;42.5557;36.3081;26.6907;30.9494;40.2068;17.8875;37.1918;13.6792;48.098;8.2378;43.1133;58.8146;23.1774;1.51564;43.3787;24.741;43.6084;24.2098 108.188;26.7838;121.883;218.525;135.846;60.0774;76.6397;92.543;89.5095;147.824;147.467;101.057;31.358;55.8619;102.838;85.0816;48.4857;63.3196;105.902;26.3528;89.36;131.659;171.379;36.8422;125.437;118.773;35.9474;8.55785;127.439;33.4642;98.7727;50.4329 21 11 21 257644;29142;78968;64159;299270;24679;25664;24614;65035;259241;63868;24471;29455;299626;58868;65210;25599;25612;25649;155423;50559 ZWINT_10214;VNN1_10157;SREBF1_32750;SPTAN1_9932;SERPINA6_32325;PRKAR2B_33052;PPARG_32510;ORM1_9400;NR1I3_32602;NR1D2_9358;HSPD1_8849;HSPB1_8847;GDF15_33113;GADD45B_8679;FZD1_8671;CYP2J4_32580;CD74_8252;ASNS_8091;APOA2_33095;ANXA7_8051;ACOT1_7968 45.84459428571429 41.2009 28.822417390428672 29.764259047619042 30.9494 15.508390401135099 72.38005 63.3196 40.683870573268976 59.0663;20.7328;41.2009;47.5519;68.3847;108.746;60.1903;24.2519;22.095;99.0234;34.4455;41.6322;21.3654;52.5718;25.231;16.3155;94.9138;28.1893;3.54778;64.7676;28.5134 40.5797;16.8296;31.4864;34.4152;36.9679;59.3814;43.9036;19.7133;12.9529;42.5557;26.6907;30.9494;17.8875;37.1918;13.6792;8.2378;58.8146;23.1774;1.51564;43.3787;24.741 108.188;26.7838;60.0774;76.6397;89.5095;147.467;101.057;31.358;55.8619;102.838;48.4857;63.3196;26.3528;89.36;131.659;36.8422;118.773;35.9474;8.55785;127.439;33.4642 11 365813;360243;361604;84386;309607;24484;102551184;25427;306575;170465;114628 TRIM59_10085;TOP2A_10059;SYTL2_32351;SLPI_9890;RT1-CE5_32445;IGFBP3_8881;HIST1H4A_32934;CYP51_8429;CKAP2_8324;ACAA2_7955;ABCG5_7947 58.80096363636364 56.1278 12.382648653521011 36.077327272727274 37.8192 9.354018425798733 123.05692727272726 121.883 45.568274651781415 56.1278;54.9577;67.0093;53.7429;54.8206;50.946;58.3303;75.1522;64.2131;78.3988;33.1119 33.6269;18.8326;44.4373;37.8192;26.5902;36.3081;40.2068;48.098;43.1133;43.6084;24.2098 121.883;218.525;135.846;92.543;147.824;85.0816;105.902;171.379;125.437;98.7727;50.4329 0 Exp 2,11(0.35);Exp 4,1(0.04);Hill,1(0.04);Linear,12(0.38);Poly 2,5(0.16);Power,2(0.07) 2.1847582842502176 115.94639909267426 1.5062377452850342 50.888092041015625 8.669031033392606 1.7333461046218872 41.63970263742321 58.956989862576776 27.12496176411993 36.74379073588009 73.05501685375643 106.54543627124355 UP 0.65625 0.34375 0.0 GO:1903530 5 regulation of secretion by cell 205 222 10 10 9 10 9 9 87 213 2238 0.67588 0.46166 0.71529 4.05 78968;309607;25664;24614;24484;63868;25427;65210;25649 srebf1;rt1-ce5;pparg;orm1;igfbp3;hspd1;cyp51;cyp2j4;apoa2 SREBF1_32750;RT1-CE5_32445;PPARG_32510;ORM1_9400;IGFBP3_8881;HSPD1_8849;CYP51_8429;CYP2J4_32580;APOA2_33095 25664(0.0441) 40.09674222222222 41.2009 3.54778 22.783556064682806 36.54092769080704 20.57129943812282 26.949304444444447 26.6907 1.51564 15.380324403460337 24.943556530563345 14.586631430713867 76.74030555555557 60.0774 8.55785 54.82527680097956 66.67636649411322 46.18480137584355 41.2009;54.8206;60.1903;24.2519;50.946;34.4455;75.1522;16.3155;3.54778 31.4864;26.5902;43.9036;19.7133;36.3081;26.6907;48.098;8.2378;1.51564 60.0774;147.824;101.057;31.358;85.0816;48.4857;171.379;36.8422;8.55785 6 3 6 78968;25664;24614;63868;65210;25649 SREBF1_32750;PPARG_32510;ORM1_9400;HSPD1_8849;CYP2J4_32580;APOA2_33095 29.991979999999998 29.3487 19.8831717591334 21.92457333333333 23.201999999999998 15.530384152733205 47.72969166666667 42.66395 31.361894732755164 41.2009;60.1903;24.2519;34.4455;16.3155;3.54778 31.4864;43.9036;19.7133;26.6907;8.2378;1.51564 60.0774;101.057;31.358;48.4857;36.8422;8.55785 3 309607;24484;25427 RT1-CE5_32445;IGFBP3_8881;CYP51_8429 60.30626666666666 54.8206 13.002093435033238 36.99876666666667 36.3081 10.770521368222306 134.76153333333332 147.824 44.60696513161749 54.8206;50.946;75.1522 26.5902;36.3081;48.098 147.824;85.0816;171.379 0 Exp 2,5(0.56);Exp 4,1(0.12);Hill,1(0.12);Linear,2(0.23) 1.8874540034070466 17.563165426254272 1.5239794254302979 3.5849626064300537 0.6273195568053799 1.7380040884017944 25.211485593296125 54.98199885114831 16.900825834183685 36.9977830547052 40.92112471224892 112.55948639886222 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0002718 6 regulation of cytokine production involved in immune response 32 36 4 4 3 4 3 3 93 33 2418 0.95564 0.15203 0.15203 8.33 309607;25599;25649 rt1-ce5;cd74;apoa2 RT1-CE5_32445;CD74_8252;APOA2_33095 51.09405999999999 54.8206 3.54778 45.79686373474499 55.53195641033253 46.22108150550879 28.97348 26.5902 1.51564 28.72373098918732 31.97107952889944 29.308642649267043 91.71828333333333 118.773 8.55785 73.46926843511396 94.72720009649646 70.33587378388961 0.5 29.18419 54.8206;94.9138;3.54778 26.5902;58.8146;1.51564 147.824;118.773;8.55785 2 1 2 25599;25649 CD74_8252;APOA2_33095 49.23079 49.23079 64.60553231202573 30.165119999999998 30.165119999999998 40.51648317093674 63.665425 63.665425 77.9338799544925 94.9138;3.54778 58.8146;1.51564 118.773;8.55785 1 309607 RT1-CE5_32445 54.8206 54.8206 26.5902 26.5902 147.824 147.824 54.8206 26.5902 147.824 0 Exp 2,1(0.34);Hill,1(0.34);Poly 2,1(0.34) 1.7420919802150931 5.2315274477005005 1.6577342748641968 1.8475407361984253 0.09611805490069261 1.7262524366378784 -0.7299699463794198 102.91808994637941 -3.5304814847258896 61.47744148472588 8.579979593304586 174.85658707336205 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0010667 11 negative regulation of cardiac muscle cell apoptotic process 9 11 1 1 1 1 1 1 95 10 2441 0.93803 0.34523 0.34523 9.09 50559 acot1 ACOT1_7968 28.5134 28.5134 28.5134 28.5134 24.741 24.741 24.741 24.741 33.4642 33.4642 33.4642 33.4642 0.0 28.5134 28.5134 24.741 33.4642 1 0 1 50559 ACOT1_7968 28.5134 28.5134 24.741 24.741 33.4642 33.4642 28.5134 24.741 33.4642 0 0 Exp 2,1(1) 50.888092041015625 50.888092041015625 50.888092041015625 50.888092041015625 0.0 50.888092041015625 28.5134 28.5134 24.741 24.741 33.4642 33.4642 UP 1.0 0.0 0.0 GO:0014850 4 response to muscle activity 13 13 2 2 2 2 2 2 94 11 2440 0.98873 0.083726 0.083726 15.38 24950;114628 srd5a1;abcg5 SRD5A1_32503;ABCG5_7947 31.1603 31.1603 29.2087 2.7599791883273475 31.863461702821727 2.5746091663336834 23.570300000000003 23.570300000000003 22.9308 0.9043895731375391 23.800711923014195 0.8436475516859776 45.20905 45.20905 39.9852 7.387639517802694 47.09120375142717 6.891459363369747 0.0 29.2087 0.5 31.1603 29.2087;33.1119 22.9308;24.2098 39.9852;50.4329 0 2 0 2 24950;114628 SRD5A1_32503;ABCG5_7947 31.1603 31.1603 2.7599791883273475 23.570300000000003 23.570300000000003 0.9043895731375391 45.20905 45.20905 7.387639517802694 29.2087;33.1119 22.9308;24.2098 39.9852;50.4329 0 Exp 2,1(0.5);Linear,1(0.5) 2.2227490655833244 4.483264923095703 1.9512832164764404 2.5319817066192627 0.41061584020477915 2.2416324615478516 27.335164000000002 34.985436 22.316880000000005 24.82372 34.970304 55.447796 DOWN 0.0 1.0 0.0 GO:0016042 5 lipid catabolic process 77 87 17 17 15 17 15 15 81 72 2379 1.0 4.1746E-7 4.1746E-7 17.24 360268;24950;364975;171142;291075;29740;64526;117543;311849;25413;25649;502970;50681;192272;170465 sult1e1;srd5a1;gcdh;ehhadh;eci2;eci1;ech1;decr1;crat;cpt2;apoa2;angptl3;acox1;acot2;acaa2 SULT1E1_32446;SRD5A1_32503;GCDH_8693;EHHADH_8534;ECI2_8521;ECI1_8520;ECH1_8516;DECR1_8458;CRAT_8375;CPT2_8374;APOA2_33095;ANGPTL3_8045;ACOX1_7973;ACOT2_7969;ACAA2_7955 25.422132666666666 15.9021 3.54778 22.51507208282565 29.387924867952695 24.914158900201834 17.597716666666667 11.3249 1.51564 14.976465396486324 20.178018683316107 16.6393703641922 39.53465666666666 31.2818 8.55785 32.06422728815929 46.24540986393385 36.58261490509601 3.5 9.429775 7.5 18.761000000000003 59.2729;29.2087;15.9021;7.29984;8.72912;11.7653;9.87438;21.6199;8.98517;31.2175;3.54778;58.0729;23.8014;13.6362;78.3988 45.3114;22.9308;10.4227;5.26587;5.10151;8.40998;6.59127;17.4928;1.97988;24.8356;1.51564;40.0757;19.0993;11.3249;43.6084 91.5578;39.9852;31.2818;11.8779;17.7951;18.8402;19.44;28.0829;31.3726;42.0237;8.55785;105.112;31.3543;16.9658;98.7727 13 2 13 360268;364975;171142;291075;29740;64526;117543;311849;25413;25649;502970;50681;192272 SULT1E1_32446;GCDH_8693;EHHADH_8534;ECI2_8521;ECI1_8520;ECH1_8516;DECR1_8458;CRAT_8375;CPT2_8374;APOA2_33095;ANGPTL3_8045;ACOX1_7973;ACOT2_7969 21.05573 13.6362 18.321849614131025 15.186657692307689 10.4227 14.022464493302142 34.94322692307692 28.0829 29.735221375196176 59.2729;15.9021;7.29984;8.72912;11.7653;9.87438;21.6199;8.98517;31.2175;3.54778;58.0729;23.8014;13.6362 45.3114;10.4227;5.26587;5.10151;8.40998;6.59127;17.4928;1.97988;24.8356;1.51564;40.0757;19.0993;11.3249 91.5578;31.2818;11.8779;17.7951;18.8402;19.44;28.0829;31.3726;42.0237;8.55785;105.112;31.3543;16.9658 2 24950;170465 SRD5A1_32503;ACAA2_7955 53.803749999999994 53.803749999999994 34.7826532772444 33.269600000000004 33.269600000000004 14.621271178662951 69.37895 69.37895 41.569039899004146 29.2087;78.3988 22.9308;43.6084 39.9852;98.7727 0 Exp 2,2(0.14);Hill,5(0.34);Linear,5(0.34);Poly 2,3(0.2) 2.1981654481046315 35.558467626571655 1.5375925302505493 4.473705768585205 1.0200788467552862 1.8691840171813965 14.027934102515413 36.81633123081792 10.018579460755955 25.17685387257738 23.3079188093161 55.76139452401724 UP 0.8666666666666667 0.13333333333333333 0.0 GO:0045862 8 positive regulation of proteolysis 112 119 4 4 3 4 3 3 93 116 2335 0.33397 0.83674 0.62445 2.52 25664;63868;64515 pparg;hspd1;cdc20 PPARG_32510;HSPD1_8849;CDC20_8255 25664(0.0441) 65.4016 60.1903 34.4455 33.86383467402945 63.55089939943104 30.683528595297847 40.714733333333335 43.9036 26.6907 12.732698422696279 40.92152864292487 11.752797058261669 200.90423333333334 101.057 48.4857 220.04419594677643 177.819577478664 202.32714778977345 60.1903;34.4455;101.569 43.9036;26.6907;51.5499 101.057;48.4857;453.17 2 1 2 25664;63868 PPARG_32510;HSPD1_8849 47.3179 47.3179 18.204322660291428 35.29715 35.29715 12.171358313885893 74.77135 74.77135 37.173522725792346 60.1903;34.4455 43.9036;26.6907 101.057;48.4857 1 64515 CDC20_8255 101.569 101.569 51.5499 51.5499 453.17 453.17 101.569 51.5499 453.17 0 Exp 2,3(1) 1.5685360782195301 4.709090709686279 1.5239794254302979 1.6557694673538208 0.07458923201019993 1.5293418169021606 27.081063632905973 103.72213636709404 26.306328684099412 55.12313798256726 -48.09921516309947 449.90768182976615 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0019751 5 polyol metabolic process 22 25 2 2 2 2 2 2 94 23 2428 0.93448 0.24238 0.24238 8.0 25315;502970 ephx1;angptl3 EPHX1_8567;ANGPTL3_8045 46.04315 46.04315 34.0134 17.01263560195776 49.882193328450626 16.123066171468707 33.1168 33.1168 26.1579 9.841370759198137 35.337587515813304 9.326777795102421 76.74005 76.74005 48.3681 40.12399648097135 85.79436495772023 38.02596290559656 0.5 46.04315 34.0134;58.0729 26.1579;40.0757 48.3681;105.112 2 0 2 25315;502970 EPHX1_8567;ANGPTL3_8045 46.04315 46.04315 17.01263560195776 33.1168 33.1168 9.841370759198137 76.74005 76.74005 40.12399648097135 34.0134;58.0729 26.1579;40.0757 48.3681;105.112 0 0 Linear,2(1) 1.7537202707269448 3.537819981575012 1.5375925302505493 2.000227451324463 0.3271322899050675 1.768909990787506 22.464840000000002 69.62145999999998 19.477356000000004 46.756243999999995 21.131028000000015 132.34907199999998 UP 1.0 0.0 0.0 GO:0006996 5 organelle organization 397 425 21 20 19 20 18 18 78 407 2044 0.76029 0.33113 0.5769 4.24 257644;360243;25123;64159;308761;54133;304951;362094;316273;25626;293502;303575;63868;25460;64515;362485;50681;170465 zwint;top2a;tagln;sptan1;prc1;pdlim1;nuf2;mrps2;mcm3;krt8;kif22;kif18b;hspd1;hmmr;cdc20;ccne2;acox1;acaa2 ZWINT_10214;TOP2A_10059;TAGLN_9981;SPTAN1_9932;PRC1_9556;PDLIM1_9452;NUF2_33136;MRPS2_9250;MCM3_9207;KRT8_8978;KIF22_8963;KIF18B_32882;HSPD1_8849;HMMR_8814;CDC20_8255;CCNE2_8227;ACOX1_7973;ACAA2_7955 61.15258333333338 64.64905 5.73955E-13 25.464917732331365 64.22340201759074 20.635669211022428 38.39202222222225 43.781800000000004 5.73955E-13 14.544346785710399 40.57105819913505 11.898494117476277 149.9972666666667 117.8335 5.73957E-13 119.66082601764823 149.7110407648574 104.96727262208434 59.0663;54.9577;45.9044;47.5519;80.3005;67.1147;5.73955E-13;63.3158;54.0045;68.9539;73.9175;65.9823;34.4455;103.573;101.569;77.8893;23.8014;78.3988 40.5797;18.8326;35.0852;34.4152;50.2731;47.2419;5.73955E-13;45.3429;33.259;45.3374;47.5608;43.9552;26.6907;58.9579;51.5499;49.2672;19.0993;43.6084 108.188;218.525;67.7714;76.6397;198.961;123.914;5.73957E-13;111.245;111.753;143.578;165.416;131.93;48.4857;424.786;453.17;185.461;31.3543;98.7727 8 10 8 257644;25123;64159;54133;362094;25626;63868;50681 ZWINT_10214;TAGLN_9981;SPTAN1_9932;PDLIM1_9452;MRPS2_9250;KRT8_8978;HSPD1_8849;ACOX1_7973 51.2692375 53.3091 16.256252164974875 36.724037499999994 37.83245 9.951899470659244 88.8970125 92.41385 38.9661862656563 59.0663;45.9044;47.5519;67.1147;63.3158;68.9539;34.4455;23.8014 40.5797;35.0852;34.4152;47.2419;45.3429;45.3374;26.6907;19.0993 108.188;67.7714;76.6397;123.914;111.245;143.578;48.4857;31.3543 10 360243;308761;304951;316273;293502;303575;25460;64515;362485;170465 TOP2A_10059;PRC1_9556;NUF2_33136;MCM3_9207;KIF22_8963;KIF18B_32882;HMMR_8814;CDC20_8255;CCNE2_8227;ACAA2_7955 69.05926000000005 75.9034 29.377608437916575 39.72641000000006 45.757999999999996 17.835049714876224 198.87747000000007 175.4385 141.04014749837904 54.9577;80.3005;5.73955E-13;54.0045;73.9175;65.9823;103.573;101.569;77.8893;78.3988 18.8326;50.2731;5.73955E-13;33.259;47.5608;43.9552;58.9579;51.5499;49.2672;43.6084 218.525;198.961;5.73957E-13;111.753;165.416;131.93;424.786;453.17;185.461;98.7727 0 Exp 2,7(0.39);Hill,1(0.06);Linear,9(0.5);Poly 2,1(0.06) 1.6994210472298528 30.847362160682678 1.5062377452850342 2.5474231243133545 0.24838887505727542 1.6458685994148254 49.38839153955248 72.91677512711425 31.672876812020593 45.11116763242391 94.71678540728438 205.27774792604902 CONFLICT 0.4444444444444444 0.5555555555555556 0.0 GO:0007080 6 mitotic metaphase plate congression 13 14 1 1 1 1 1 1 95 13 2438 0.90465 0.41684 0.41684 7.14 293502 kif22 KIF22_8963 73.9175 73.9175 73.9175 73.9175 47.5608 47.5608 47.5608 47.5608 165.416 165.416 165.416 165.416 0.0 73.9175 73.9175 47.5608 165.416 0 1 0 1 293502 KIF22_8963 73.9175 73.9175 47.5608 47.5608 165.416 165.416 73.9175 47.5608 165.416 0 Linear,1(1) 2.020775556564331 2.020775556564331 2.020775556564331 2.020775556564331 0.0 2.020775556564331 73.9175 73.9175 47.5608 47.5608 165.416 165.416 DOWN 0.0 1.0 0.0 GO:0006637 7 acyl-CoA metabolic process 29 31 8 8 8 8 8 8 88 23 2428 1.0 1.1729E-5 1.1729E-5 25.81 298490;364975;24763;681337;314304;192272;50559;170465 ppcs;gcdh;acsm3;acot4;acot3;acot2;acot1;acaa2 PPCS_9540;GCDH_8693;ACSM3_7976;ACOT4_7971;ACOT3_7970;ACOT2_7969;ACOT1_7968;ACAA2_7955 30.8706 22.20775 12.3157 23.40165618436927 32.87959841546506 28.137497468804575 21.46192 18.006149999999998 6.70485 14.974416734996494 21.14928678561242 15.924879474846708 43.485749999999996 32.373 16.9658 27.534551105370976 45.37085524322612 33.39101575272413 0.5 12.975950000000001 2.5 15.505600000000001 15.1091;15.9021;52.2057;12.3157;30.8838;13.6362;28.5134;78.3988 7.94061;10.4227;42.2655;6.70485;24.6874;11.3249;24.741;43.6084 30.6311;31.2818;71.1126;24.3993;41.2585;16.9658;33.4642;98.7727 7 1 7 298490;364975;24763;681337;314304;192272;50559 PPCS_9540;GCDH_8693;ACSM3_7976;ACOT4_7971;ACOT3_7970;ACOT2_7969;ACOT1_7968 24.080857142857145 15.9021 14.444309914848498 18.298137142857144 11.3249 12.968544416606305 35.58761428571428 31.2818 17.386536253610018 15.1091;15.9021;52.2057;12.3157;30.8838;13.6362;28.5134 7.94061;10.4227;42.2655;6.70485;24.6874;11.3249;24.741 30.6311;31.2818;71.1126;24.3993;41.2585;16.9658;33.4642 1 170465 ACAA2_7955 78.3988 78.3988 43.6084 43.6084 98.7727 98.7727 78.3988 43.6084 98.7727 0 Exp 2,3(0.38);Hill,2(0.25);Linear,1(0.13);Poly 2,2(0.25) 3.458863429542429 68.37944841384888 1.5464483499526978 50.888092041015625 17.132880885720766 2.4932953119277954 14.654079616615657 47.087120383384345 11.08517861472325 31.83866138527675 24.40527955253534 62.56622044746465 UP 0.875 0.125 0.0 GO:0048545 5 response to steroid hormone 158 177 9 9 7 9 7 7 89 170 2281 0.6506 0.50588 0.83765 3.95 286954;78968;24950;24614;63868;25315;25649 ugt2b1;srebf1;srd5a1;orm1;hspd1;ephx1;apoa2 UGT2B10_33303,UGT2B1_33224;SREBF1_32750;SRD5A1_32503;ORM1_9400;HSPD1_8849;EPHX1_8567;APOA2_33095 25.601761428571425 29.2087 3.54778 13.316730982442646 26.29831694441191 13.686112401574565 19.406140714285716 22.9308 1.51564 10.973940014271854 19.982336388765255 11.181341038446002 37.47544285714286 39.9852 8.55785 17.19585230209184 38.39936207336784 18.0386610585472 12.54415;41.2009;29.2087;24.2519;34.4455;34.0134;3.54778 7.348245;31.4864;22.9308;19.7133;26.6907;26.1579;1.51564 25.495849999999997;60.0774;39.9852;31.358;48.4857;48.3681;8.55785 7 1 6 286954;78968;24614;63868;25315;25649 UGT2B10_33303,UGT2B1_33224;SREBF1_32750;ORM1_9400;HSPD1_8849;EPHX1_8567;APOA2_33095 25.000604999999997 29.132649999999998 14.483325613855058 18.8186975 22.9356 11.900171396753812 37.05715 39.86305 18.798060133801044 12.54415;41.2009;24.2519;34.4455;34.0134;3.54778 7.348245;31.4864;19.7133;26.6907;26.1579;1.51564 25.495849999999997;60.0774;31.358;48.4857;48.3681;8.55785 1 24950 SRD5A1_32503 29.2087 29.2087 22.9308 22.9308 39.9852 39.9852 29.2087 22.9308 39.9852 0 Exp 2,3(0.38);Exp 4,1(0.13);Hill,1(0.13);Linear,2(0.25);Poly 2,1(0.13) 1.9583937968254086 16.196168541908264 1.635288953781128 3.5849626064300537 0.6455070051824827 1.82119220495224 15.736589060921654 35.466933796221205 11.276532183800617 27.535749244770813 24.736577200665742 50.21430851361996 UP 0.8571428571428571 0.14285714285714285 0.0 GO:0022610 2 biological adhesion 150 155 3 3 3 3 3 3 93 152 2299 0.15221 0.93985 0.27826 1.94 29142;63868;502970 vnn1;hspd1;angptl3 VNN1_10157;HSPD1_8849;ANGPTL3_8045 37.750400000000006 34.4455 20.7328 18.888158724714266 45.86759371612466 17.592646685516147 27.865333333333336 26.6907 16.8296 11.667481043624328 32.887818535456184 10.571565364490647 60.12716666666666 48.4857 26.7838 40.44093889146657 77.31927211495031 39.183045919397344 20.7328;34.4455;58.0729 16.8296;26.6907;40.0757 26.7838;48.4857;105.112 3 0 3 29142;63868;502970 VNN1_10157;HSPD1_8849;ANGPTL3_8045 37.750400000000006 34.4455 18.888158724714266 27.865333333333336 26.6907 11.667481043624328 60.12716666666666 48.4857 40.44093889146657 20.7328;34.4455;58.0729 16.8296;26.6907;40.0757 26.7838;48.4857;105.112 0 0 Exp 2,1(0.34);Linear,2(0.67) 2.272307423329999 7.801867723464966 1.5375925302505493 4.608505725860596 1.739881464149 1.6557694673538208 16.376436292548078 59.12436370745192 14.66233562358265 41.068331043084015 14.363936234338588 105.89039709899475 UP 1.0 0.0 0.0 GO:0035691 7 macrophage migration inhibitory factor signaling pathway 1 1 1 1 1 1 1 1 95 0 2451 1.0 0.037691 0.037691 100.0 25599 cd74 CD74_8252 94.9138 94.9138 94.9138 94.9138 58.8146 58.8146 58.8146 58.81459999999999 118.773 118.773 118.773 118.773 0.0 94.9138 0.0 94.9138 94.9138 58.8146 118.773 1 0 1 25599 CD74_8252 94.9138 94.9138 58.8146 58.8146 118.773 118.773 94.9138 58.8146 118.773 0 0 Poly 2,1(1) 1.6577342748641968 1.6577342748641968 1.6577342748641968 1.6577342748641968 0.0 1.6577342748641968 94.9138 94.9138 58.8146 58.8146 118.773 118.773 UP 1.0 0.0 0.0 GO:0062012 5 regulation of small molecule metabolic process 117 127 9 9 6 9 6 6 90 121 2330 0.80051 0.34475 0.47685 4.72 78968;25664;24484;65030;25427;25599 srebf1;pparg;igfbp3;ephx2;cyp51;cd74 SREBF1_32750;PPARG_32510;IGFBP3_8881;EPHX2_33282;CYP51_8429;CD74_8252 25664(0.0441) 54.80744166666667 55.56815 6.44145 30.30089831015603 53.07477139969096 31.212324620495487 36.87907833333333 40.105850000000004 2.66377 19.268988240206497 36.12368537702807 19.86104946891812 92.28588333333335 93.0693 17.3473 52.42003492926785 81.65283779809425 43.17716494947632 41.2009;60.1903;50.946;6.44145;75.1522;94.9138 31.4864;43.9036;36.3081;2.66377;48.098;58.8146 60.0774;101.057;85.0816;17.3473;171.379;118.773 4 2 4 78968;25664;65030;25599 SREBF1_32750;PPARG_32510;EPHX2_33282;CD74_8252 50.686612499999995 50.6956 36.94129277895706 34.2170925 37.695 23.8183028018278 74.31367499999999 80.5672 45.23890809921443 41.2009;60.1903;6.44145;94.9138 31.4864;43.9036;2.66377;58.8146 60.0774;101.057;17.3473;118.773 2 24484;25427 IGFBP3_8881;CYP51_8429 63.049099999999996 63.049099999999996 17.116368166757773 42.203050000000005 42.203050000000005 8.33671823951123 128.2303 128.2303 61.02147673876788 50.946;75.1522 36.3081;48.098 85.0816;171.379 0 Exp 2,2(0.34);Exp 4,1(0.17);Linear,2(0.34);Poly 2,1(0.17) 1.7870231844423288 10.839839816093445 1.5239794254302979 2.3739430904388428 0.30651799292953463 1.6978691816329956 30.561673394771173 79.05320993856215 21.46067657758946 52.297480089077204 50.34111962731131 134.23064703935535 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0010661 9 positive regulation of muscle cell apoptotic process 12 12 2 2 2 2 2 2 94 10 2441 0.99109 0.072579 0.072579 16.67 25664;24484 pparg;igfbp3 PPARG_32510;IGFBP3_8881 25664(0.0441) 55.56815 55.56815 50.946 6.536707217322738 56.84722031121418 6.2814408795228465 40.105850000000004 40.105850000000004 36.3081 5.370829556502322 41.15678717737712 5.161092154129092 93.0693 93.0693 85.0816 11.296313672167583 95.27970639634921 10.855178934773877 0.0 50.946 0.5 55.56815 60.1903;50.946 43.9036;36.3081 101.057;85.0816 1 1 1 25664 PPARG_32510 60.1903 60.1903 43.9036 43.9036 101.057 101.057 60.1903 43.9036 101.057 1 24484 IGFBP3_8881 50.946 50.946 36.3081 36.3081 85.0816 85.0816 50.946 36.3081 85.0816 0 Exp 2,1(0.5);Linear,1(0.5) 1.627477333801634 3.2619835138320923 1.5239794254302979 1.7380040884017944 0.1513382905283106 1.6309917569160461 46.508736 64.627564 32.66226000000001 47.54944 77.41340799999999 108.725192 CONFLICT 0.5 0.5 0.0 GO:0007623 3 circadian rhythm 58 63 5 4 4 5 3 3 93 60 2391 0.78834 0.42663 0.51284 4.76 78968;24950;259241 srebf1;srd5a1;nr1d2 SREBF1_32750;SRD5A1_32503;NR1D2_9358 56.477666666666664 41.2009 29.2087 37.330386869992836 50.85245523529771 31.603837772212607 32.3243 31.4864 22.9308 9.839244498944003 31.831625390123 8.124088025455709 67.63353333333333 60.0774 39.9852 32.10046697749633 64.52104948289579 26.646680161649122 41.2009;29.2087;99.0234 31.4864;22.9308;42.5557 60.0774;39.9852;102.838 2 1 2 78968;259241 SREBF1_32750;NR1D2_9358 70.11215 70.11215 40.88668185515915 37.02105 37.02105 7.827177092988234 81.45769999999999 81.45769999999999 30.236310227605514 41.2009;99.0234 31.4864;42.5557 60.0774;102.838 1 24950 SRD5A1_32503 29.2087 29.2087 22.9308 22.9308 39.9852 39.9852 29.2087 22.9308 39.9852 0 Exp 2,1(0.34);Linear,1(0.34);Power,1(0.34) 2.167084997573171 6.590891122817993 1.912555456161499 2.7270524501800537 0.4594785262746897 1.9512832164764404 14.234357206313923 98.72097612701941 21.190146698227778 43.458453301772224 31.308435362215732 103.95863130445093 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0044237 3 cellular metabolic process 1201 1328 74 72 64 72 61 61 35 1267 1184 0.9918 0.014352 0.028267 4.59 29142;286954;365813;360243;360268;64305;78968;24950;293820;24679;298490;25664;313245;296371;680308;362094;291234;24552;316273;315994;293502;24484;63868;364975;65030;25315;171142;291075;29740;64526;117543;114027;50549;266682;65210;25086;24303;499353;171521;29277;24894;311849;25413;297594;64515;25599;362485;114494;25612;25649;155423;502970;65155;26760;24763;50681;681337;314304;192272;50559;170465 vnn1;ugt2b1;trim59;top2a;sult1e1;sult1b1;srebf1;srd5a1;psat1;prkar2b;ppcs;pparg;polr1e;pltp;mthfd2;mrps2;mki67;me1;mcm3;mapkapk3;kif22;igfbp3;hspd1;gcdh;ephx2;ephx1;ehhadh;eci2;eci1;ech1;decr1;dao;cyp4a1;cyp3a2;cyp2j4;cyp2e1;cyp2d3;cyp2c24;cyp2c13;cyp2c11;cyp2a1;crat;cpt2;cdca3;cdc20;cd74;ccne2;ccna2;asns;apoa2;anxa7;angptl3;alas1;akr7a3;acsm3;acox1;acot4;acot3;acot2;acot1;acaa2 VNN1_10157;UGT2B10_33303,UGT2B1_33224;TRIM59_10085;TOP2A_10059;SULT1E1_32446;SULT1B1_32942;SREBF1_32750;SRD5A1_32503;PSAT1_9583;PRKAR2B_33052;PPCS_9540;PPARG_32510;POLR1E_9523;PLTP_32412;MTHFD2_9261;MRPS2_9250;MKI67_9232;ME1_9215;MCM3_9207;MAPKAPK3_9194;KIF22_8963;IGFBP3_8881;HSPD1_8849;GCDH_8693;EPHX2_33282;EPHX1_8567;EHHADH_8534;ECI2_8521;ECI1_8520;ECH1_8516;DECR1_8458;DAO_8437;CYP4A1_33111;CYP3A2_32374;CYP2J4_32580;CYP2E1_8421;CYP2D3_8420;CYP2C24_32875;CYP2C13_8419;CYP2C11_32593;CYP2A1_32717;CRAT_8375;CPT2_8374;CDCA3_8260;CDC20_8255;CD74_8252;CCNE2_8227;CCNA2_8221;ASNS_8091;APOA2_33095;ANXA7_8051;ANGPTL3_8045;ALAS1_8018;AKR7A3_8015;ACSM3_7976;ACOX1_7973;ACOT4_7971;ACOT3_7970;ACOT2_7969;ACOT1_7968;ACAA2_7955 25664(0.0441) 40.743213114754106 31.2175 3.54778 28.939865164299658 42.517021161345745 29.501772086998564 26.794011557377043 24.6874 1.51564 17.626991930800088 27.763007803590014 18.04579134185956 78.07763770491805 48.3681 8.55785 83.39664746580627 80.22985911602935 82.99737172019243 20.7328;12.54415;56.1278;54.9577;59.2729;15.4629;41.2009;29.2087;26.3316;108.746;15.1091;60.1903;73.982;87.0256;57.4184;63.3158;49.7822;49.3339;54.0045;104.193;73.9175;50.946;34.4455;15.9021;6.44145;34.0134;7.29984;8.72912;11.7653;9.87438;21.6199;6.1336;23.208;23.2485;16.3155;7.89174;12.8059;58.9435;104.635;54.426;9.37187;8.98517;31.2175;46.7245;101.569;94.9138;77.8893;52.8265;28.1893;3.54778;64.7676;58.0729;27.1843;18.819;52.2057;23.8014;12.3157;30.8838;13.6362;28.5134;78.3988 16.8296;7.348245;33.6269;18.8326;45.3114;7.69418;31.4864;22.9308;20.9188;59.3814;7.94061;43.9036;47.589;56.6266;46.387;45.3429;35.6665;35.4173;33.259;59.1667;47.5608;36.3081;26.6907;10.4227;2.66377;26.1579;5.26587;5.10151;8.40998;6.59127;17.4928;2.43617;18.863;18.6955;8.2378;4.16797;8.8664;48.1505;49.2461;43.9518;4.95906;1.97988;24.8356;21.1123;51.5499;58.8146;49.2672;37.3288;23.1774;1.51564;43.3787;40.0757;21.5215;11.5469;42.2655;19.0993;6.70485;24.6874;11.3249;24.741;43.6084 26.7838;25.495849999999997;121.883;218.525;91.5578;35.0879;60.0774;39.9852;35.2954;147.467;30.6311;101.057;165.722;104.563;79.7903;111.245;82.1147;80.9924;111.753;434.985;165.416;85.0816;48.4857;31.2818;17.3473;48.3681;11.8779;17.7951;18.8402;19.44;28.0829;16.2027;29.9853;30.5145;36.8422;15.8079;22.6004;80.4167;108.327;74.8861;19.1079;31.3726;42.0237;127.486;453.17;118.773;185.461;90.0448;35.9474;8.55785;127.439;105.112;36.6615;51.6405;71.1126;31.3543;24.3993;41.2585;16.9658;33.4642;98.7727 49 13 48 29142;286954;360268;64305;78968;293820;24679;298490;25664;313245;296371;680308;362094;24552;63868;364975;65030;25315;171142;291075;29740;64526;117543;114027;50549;266682;65210;25086;24303;499353;171521;29277;24894;311849;25413;25599;25612;25649;155423;502970;65155;26760;24763;50681;681337;314304;192272;50559 VNN1_10157;UGT2B10_33303,UGT2B1_33224;SULT1E1_32446;SULT1B1_32942;SREBF1_32750;PSAT1_9583;PRKAR2B_33052;PPCS_9540;PPARG_32510;POLR1E_9523;PLTP_32412;MTHFD2_9261;MRPS2_9250;ME1_9215;HSPD1_8849;GCDH_8693;EPHX2_33282;EPHX1_8567;EHHADH_8534;ECI2_8521;ECI1_8520;ECH1_8516;DECR1_8458;DAO_8437;CYP4A1_33111;CYP3A2_32374;CYP2J4_32580;CYP2E1_8421;CYP2D3_8420;CYP2C24_32875;CYP2C13_8419;CYP2C11_32593;CYP2A1_32717;CRAT_8375;CPT2_8374;CD74_8252;ASNS_8091;APOA2_33095;ANXA7_8051;ANGPTL3_8045;ALAS1_8018;AKR7A3_8015;ACSM3_7976;ACOX1_7973;ACOT4_7971;ACOT3_7970;ACOT2_7969;ACOT1_7968 34.47480208333334 25.0665 27.53168353199211 23.83784802083333 20.009050000000002 17.783578095337177 53.084539583333346 35.6214 39.349177670276866 20.7328;12.54415;59.2729;15.4629;41.2009;26.3316;108.746;15.1091;60.1903;73.982;87.0256;57.4184;63.3158;49.3339;34.4455;15.9021;6.44145;34.0134;7.29984;8.72912;11.7653;9.87438;21.6199;6.1336;23.208;23.2485;16.3155;7.89174;12.8059;58.9435;104.635;54.426;9.37187;8.98517;31.2175;94.9138;28.1893;3.54778;64.7676;58.0729;27.1843;18.819;52.2057;23.8014;12.3157;30.8838;13.6362;28.5134 16.8296;7.348245;45.3114;7.69418;31.4864;20.9188;59.3814;7.94061;43.9036;47.589;56.6266;46.387;45.3429;35.4173;26.6907;10.4227;2.66377;26.1579;5.26587;5.10151;8.40998;6.59127;17.4928;2.43617;18.863;18.6955;8.2378;4.16797;8.8664;48.1505;49.2461;43.9518;4.95906;1.97988;24.8356;58.8146;23.1774;1.51564;43.3787;40.0757;21.5215;11.5469;42.2655;19.0993;6.70485;24.6874;11.3249;24.741 26.7838;25.495849999999997;91.5578;35.0879;60.0774;35.2954;147.467;30.6311;101.057;165.722;104.563;79.7903;111.245;80.9924;48.4857;31.2818;17.3473;48.3681;11.8779;17.7951;18.8402;19.44;28.0829;16.2027;29.9853;30.5145;36.8422;15.8079;22.6004;80.4167;108.327;74.8861;19.1079;31.3726;42.0237;118.773;35.9474;8.55785;127.439;105.112;36.6615;51.6405;71.1126;31.3543;24.3993;41.2585;16.9658;33.4642 13 365813;360243;24950;291234;316273;315994;293502;24484;297594;64515;362485;114494;170465 TRIM59_10085;TOP2A_10059;SRD5A1_32503;MKI67_9232;MCM3_9207;MAPKAPK3_9194;KIF22_8963;IGFBP3_8881;CDCA3_8260;CDC20_8255;CCNE2_8227;CCNA2_8221;ACAA2_7955 63.88811538461538 54.9577 21.93790712711852 37.70907692307692 36.3081 12.282661612557357 170.35984615384618 121.883 130.3315378073397 56.1278;54.9577;29.2087;49.7822;54.0045;104.193;73.9175;50.946;46.7245;101.569;77.8893;52.8265;78.3988 33.6269;18.8326;22.9308;35.6665;33.259;59.1667;47.5608;36.3081;21.1123;51.5499;49.2672;37.3288;43.6084 121.883;218.525;39.9852;82.1147;111.753;434.985;165.416;85.0816;127.486;453.17;185.461;90.0448;98.7727 0 Exp 2,19(0.31);Exp 4,6(0.1);Hill,8(0.13);Linear,19(0.31);Poly 2,8(0.13);Power,2(0.04) 2.13232172767148 180.6797592639923 1.5084086656570435 50.888092041015625 6.238370990193357 1.8279361724853516 33.48068783377545 48.005738395732735 22.370477660509977 31.217545454244124 57.14905848968246 99.00621692015358 UP 0.7868852459016393 0.21311475409836064 0.0 GO:1905953 5 negative regulation of lipid localization 19 22 5 5 4 5 4 4 92 18 2433 0.99892 0.0082235 0.0082235 18.18 25664;24484;25649;114628 pparg;igfbp3;apoa2;abcg5 PPARG_32510;IGFBP3_8881;APOA2_33095;ABCG5_7947 25664(0.0441) 36.948995000000004 42.028949999999995 3.54778 24.94286049212144 38.131926391633606 24.37804271682728 26.484285 30.258950000000002 1.51564 18.516176633552078 27.44973696069239 18.119214654357524 61.2823375 67.75725 8.55785 41.01223617709263 62.95557706274793 40.364157974182206 0.5 18.32984 1.5 42.028949999999995 60.1903;50.946;3.54778;33.1119 43.9036;36.3081;1.51564;24.2098 101.057;85.0816;8.55785;50.4329 2 2 2 25664;25649 PPARG_32510;APOA2_33095 31.869040000000002 31.869040000000002 40.05230999549464 22.709619999999997 22.709619999999997 29.972813956664126 54.807425 54.807425 65.40677621899164 60.1903;3.54778 43.9036;1.51564 101.057;8.55785 2 24484;114628 IGFBP3_8881;ABCG5_7947 42.028949999999995 42.028949999999995 12.610613046359013 30.258950000000002 30.258950000000002 8.554789970829193 67.75725 67.75725 24.50033072929834 50.946;33.1119 36.3081;24.2098 85.0816;50.4329 0 Exp 2,2(0.5);Hill,1(0.25);Linear,1(0.25) 1.8445850797205154 7.520217657089233 1.5239794254302979 2.5319817066192627 0.44558274038605894 1.7321282625198364 12.504991717720973 61.392998282279024 8.338431899118959 44.63013810088104 21.090346046449227 101.47432895355077 CONFLICT 0.5 0.5 0.0 GO:0034375 8 high-density lipoprotein particle remodeling 8 8 3 3 2 3 2 2 94 6 2445 0.99747 0.033945 0.033945 25.0 296371;25649 pltp;apoa2 PLTP_32412;APOA2_33095 45.28669 45.28669 3.54778 59.02773260066999 48.48310020237639 58.854389297761706 29.07112 29.07112 1.51564 38.96933353370057 31.18134801993101 38.85489456257211 56.560425 56.560425 8.55785 67.88589259383167 60.23651334227674 67.68653604861757 0.0 3.54778 0.0 3.54778 87.0256;3.54778 56.6266;1.51564 104.563;8.55785 2 0 2 296371;25649 PLTP_32412;APOA2_33095 45.28669 45.28669 59.02773260066999 29.07112 29.07112 38.96933353370057 56.560425 56.560425 67.88589259383167 87.0256;3.54778 56.6266;1.51564 104.563;8.55785 0 0 Hill,1(0.5);Poly 2,1(0.5) 1.6136586177181844 3.234661102294922 1.5084086656570435 1.7262524366378784 0.15403880769979764 1.617330551147461 -36.52157359999999 127.0949536 -24.937620799999998 83.0798608 -37.524622 150.645472 UP 1.0 0.0 0.0 GO:0071901 9 negative regulation of protein serine/threonine kinase activity 40 43 3 3 2 3 2 2 94 41 2410 0.78088 0.48719 0.67617 4.65 24679;24471 prkar2b;hspb1 PRKAR2B_33052;HSPB1_8847 75.1891 75.1891 41.6322 47.45662309119772 66.20024928524302 45.72233809502335 45.1654 45.1654 30.9494 20.10446000269592 41.357375368374754 19.36974983859811 105.39330000000001 105.39330000000001 63.3196 59.5011971592169 94.1230632285023 57.32674759315031 108.746;41.6322 59.3814;30.9494 147.467;63.3196 2 0 2 24679;24471 PRKAR2B_33052;HSPB1_8847 75.1891 75.1891 47.45662309119772 45.1654 45.1654 20.10446000269592 105.39330000000001 105.39330000000001 59.5011971592169 108.746;41.6322 59.3814;30.9494 147.467;63.3196 0 0 Linear,1(0.5);Power,1(0.5) 1.7301363173177244 3.4676482677459717 1.6208000183105469 1.8468482494354248 0.1598402371036252 1.7338241338729858 9.417576000000011 140.960624 17.302039999999998 73.02876 22.928848000000002 187.857752 UP 1.0 0.0 0.0 GO:0071466 5 cellular response to xenobiotic stimulus 51 53 2 2 2 2 2 2 94 51 2400 0.67749 0.60134 1.0 3.77 24950;114494 srd5a1;ccna2 SRD5A1_32503;CCNA2_8221 41.0176 41.0176 29.2087 16.700306536707636 40.88669443155452 16.699280400193903 30.129800000000003 30.129800000000003 22.9308 10.180923435523901 30.049996700180458 10.180297877109293 65.015 65.015 39.9852 35.39748262348606 64.73753637535447 35.395307654461696 29.2087;52.8265 22.9308;37.3288 39.9852;90.0448 0 2 0 2 24950;114494 SRD5A1_32503;CCNA2_8221 41.0176 41.0176 16.700306536707636 30.129800000000003 30.129800000000003 10.180923435523901 65.015 65.015 35.39748262348606 29.2087;52.8265 22.9308;37.3288 39.9852;90.0448 0 Linear,2(1) 2.1302348106627296 4.276881217956543 1.9512832164764404 2.3255980014801025 0.26468052277447407 2.1384406089782715 17.872156 64.163044 16.019760000000005 44.23984 15.956592000000008 114.073408 DOWN 0.0 1.0 0.0 GO:0016559 7 peroxisome fission 4 4 2 2 1 2 1 1 95 3 2448 0.99197 0.14253 0.14253 25.0 50681 acox1 ACOX1_7973 23.8014 23.8014 23.8014 23.8014 19.0993 19.0993 19.0993 19.0993 31.3543 31.3543 31.3543 31.3543 0.0 23.8014 0.0 23.8014 23.8014 19.0993 31.3543 1 0 1 50681 ACOX1_7973 23.8014 23.8014 19.0993 19.0993 31.3543 31.3543 23.8014 19.0993 31.3543 0 0 Linear,1(1) 1.5733836889266968 1.5733836889266968 1.5733836889266968 1.5733836889266968 0.0 1.5733836889266968 23.8014 23.8014 19.0993 19.0993 31.3543 31.3543 UP 1.0 0.0 0.0 GO:0032502 2 developmental process 992 1073 42 42 30 41 30 30 66 1043 1408 0.017035 0.99029 0.034574 2.8 360243;25123;64305;78968;24950;25664;363465;54133;24614;338475;65035;259241;291234;25626;24484;25685;24471;58868;25315;50549;24303;25413;114494;25612;25649;155423;502970;65155;81633;50681 top2a;tagln;sult1b1;srebf1;srd5a1;pparg;pir;pdlim1;orm1;nrep;nr1i3;nr1d2;mki67;krt8;igfbp3;igfbp1;hspb1;fzd1;ephx1;cyp4a1;cyp2d3;cpt2;ccna2;asns;apoa2;anxa7;angptl3;alas1;acta2;acox1 TOP2A_10059;TAGLN_9981;SULT1B1_32942;SREBF1_32750;SRD5A1_32503;PPARG_32510;PIR_9487;PDLIM1_9452;ORM1_9400;NREP_9364;NR1I3_32602;NR1D2_9358;MKI67_9232;KRT8_8978;IGFBP3_8881;IGFBP1_32306;HSPB1_8847;FZD1_8671;EPHX1_8567;CYP4A1_33111;CYP2D3_8420;CPT2_8374;CCNA2_8221;ASNS_8091;APOA2_33095;ANXA7_8051;ANGPTL3_8045;ALAS1_8018;ACTA2_33040;ACOX1_7973 25664(0.0441) 45.545126 43.768299999999996 3.54778 24.68438022294185 44.42631936214144 23.46874828070768 30.695463999999998 31.2179 1.51564 15.493208682174851 30.320718781063338 15.849982440361114 87.13852500000002 71.34055000000001 8.55785 69.68135486655486 82.20200122256223 54.98062683394068 54.9577;45.9044;15.4629;41.2009;29.2087;60.1903;52.1607;67.1147;24.2519;69.4104;22.095;99.0234;49.7822;68.9539;50.946;98.8371;41.6322;25.231;34.0134;23.208;12.8059;31.2175;52.8265;28.1893;3.54778;64.7676;58.0729;27.1843;90.3558;23.8014 18.8326;35.0852;7.69418;31.4864;22.9308;43.9036;40.9644;47.2419;19.7133;43.1468;12.9529;42.5557;35.6665;45.3374;36.3081;57.328;30.9494;13.6792;26.1579;18.863;8.8664;24.8356;37.3288;23.1774;1.51564;43.3787;40.0757;21.5215;70.2676;19.0993 218.525;67.7714;35.0879;60.0774;39.9852;101.057;74.9097;123.914;31.358;157.944;55.8619;102.838;82.1147;143.578;85.0816;357.409;63.3196;131.659;48.3681;29.9853;22.6004;42.0237;90.0448;35.9474;8.55785;127.439;105.112;36.6615;103.57;31.3543 23 7 23 25123;64305;78968;25664;363465;54133;24614;65035;259241;25626;25685;24471;58868;25315;50549;24303;25413;25612;25649;155423;502970;65155;50681 TAGLN_9981;SULT1B1_32942;SREBF1_32750;PPARG_32510;PIR_9487;PDLIM1_9452;ORM1_9400;NR1I3_32602;NR1D2_9358;KRT8_8978;IGFBP1_32306;HSPB1_8847;FZD1_8671;EPHX1_8567;CYP4A1_33111;CYP2D3_8420;CPT2_8374;ASNS_8091;APOA2_33095;ANXA7_8051;ANGPTL3_8045;ALAS1_8018;ACOX1_7973 42.12462956521739 34.0134 25.555626549461845 28.538379130434777 26.1579 14.819988500403452 79.86480217391306 60.0774 72.23233238977176 45.9044;15.4629;41.2009;60.1903;52.1607;67.1147;24.2519;22.095;99.0234;68.9539;98.8371;41.6322;25.231;34.0134;23.208;12.8059;31.2175;28.1893;3.54778;64.7676;58.0729;27.1843;23.8014 35.0852;7.69418;31.4864;43.9036;40.9644;47.2419;19.7133;12.9529;42.5557;45.3374;57.328;30.9494;13.6792;26.1579;18.863;8.8664;24.8356;23.1774;1.51564;43.3787;40.0757;21.5215;19.0993 67.7714;35.0879;60.0774;101.057;74.9097;123.914;31.358;55.8619;102.838;143.578;357.409;63.3196;131.659;48.3681;29.9853;22.6004;42.0237;35.9474;8.55785;127.439;105.112;36.6615;31.3543 7 360243;24950;338475;291234;24484;114494;81633 TOP2A_10059;SRD5A1_32503;NREP_9364;MKI67_9232;IGFBP3_8881;CCNA2_8221;ACTA2_33040 56.7839 52.8265 18.92526321877716 37.783028571428574 36.3081 16.686253286734196 111.0379 90.0448 58.89100928390229 54.9577;29.2087;69.4104;49.7822;50.946;52.8265;90.3558 18.8326;22.9308;43.1468;35.6665;36.3081;37.3288;70.2676 218.525;39.9852;157.944;82.1147;85.0816;90.0448;103.57 0 Exp 2,11(0.37);Exp 4,1(0.04);Hill,1(0.04);Linear,12(0.4);Poly 2,4(0.14);Power,1(0.04) 1.9302774037308 59.40238654613495 1.5124053955078125 3.5849626064300537 0.4998530593044553 1.8522926568984985 36.711933980788764 54.37831801921124 25.151290476203457 36.23963752379654 62.20337240001612 112.07367759998385 UP 0.7666666666666667 0.23333333333333334 0.0 GO:0046942 7 carboxylic acid transport 73 76 6 6 5 6 5 5 91 71 2380 0.93582 0.1561 0.20767 6.58 117267;503568;25664;25413;140668 slc26a2;slc13a4;pparg;cpt2;abcc3 SLC26A2_33072;SLC13A4_9836;PPARG_32510;CPT2_8374;ABCC3_7941 25664(0.0441) 49.31084 54.7452 31.2175 15.43203845731342 50.740348228208255 13.815358642350802 35.28696 38.3503 24.8356 8.974173464057836 36.589859040017735 8.522210114387947 84.7865 95.3373 42.0237 38.818464282413316 85.66573863947086 32.41292563484321 2.5 57.467749999999995 54.7452;65.6237;60.1903;31.2175;34.7775 38.3503;42.6891;43.9036;24.8356;26.6562 95.3373;135.744;101.057;42.0237;49.7705 3 2 3 25664;25413;140668 PPARG_32510;CPT2_8374;ABCC3_7941 42.06176666666667 34.7775 15.800354129364736 31.798466666666666 26.6562 10.522800760887446 64.28373333333333 49.7705 32.081273097608396 60.1903;31.2175;34.7775 43.9036;24.8356;26.6562 101.057;42.0237;49.7705 2 117267;503568 SLC26A2_33072;SLC13A4_9836 60.18445 60.18445 7.692261119137861 40.5197 40.5197 3.067994902212159 115.54065 115.54065 28.571851575370424 54.7452;65.6237 38.3503;42.6891 95.3373;135.744 0 Exp 2,3(0.6);Linear,2(0.4) 1.679647962332167 8.457824945449829 1.5239086151123047 1.998015284538269 0.2285690414828022 1.5349997282028198 35.78406188739804 62.83761811260196 27.420750132256817 43.15316986774317 50.76061583229147 118.81238416770853 UP 0.6 0.4 0.0 GO:0010647 6 positive regulation of cell communication 426 450 11 11 8 10 8 8 88 442 2009 0.0067952 0.99743 0.013379 1.78 24614;24484;63868;29455;299626;65210;25599;81633 orm1;igfbp3;hspd1;gdf15;gadd45b;cyp2j4;cd74;acta2 ORM1_9400;IGFBP3_8881;HSPD1_8849;GDF15_33113;GADD45B_8679;CYP2J4_32580;CD74_8252;ACTA2_33040 48.145712499999995 42.695750000000004 16.3155 30.438075355732504 49.529753384870894 31.070880705451046 34.388925 31.4994 8.2378 21.133072466076214 34.52384593301435 21.389358630251433 67.4779125 66.78365 26.3528 35.89212870705924 70.79947824943652 35.57380730062644 24.2519;50.946;34.4455;21.3654;52.5718;16.3155;94.9138;90.3558 19.7133;36.3081;26.6907;17.8875;37.1918;8.2378;58.8146;70.2676 31.358;85.0816;48.4857;26.3528;89.36;36.8422;118.773;103.57 6 2 6 24614;63868;29455;299626;65210;25599 ORM1_9400;HSPD1_8849;GDF15_33113;GADD45B_8679;CYP2J4_32580;CD74_8252 40.64398333333333 29.3487 29.52336796420196 28.089283333333338 23.201999999999998 17.872726707407196 58.528616666666665 42.66395 37.21463785310381 24.2519;34.4455;21.3654;52.5718;16.3155;94.9138 19.7133;26.6907;17.8875;37.1918;8.2378;58.8146 31.358;48.4857;26.3528;89.36;36.8422;118.773 2 24484;81633 IGFBP3_8881;ACTA2_33040 70.65090000000001 70.65090000000001 27.866936825205553 53.287850000000006 53.287850000000006 24.01299273570454 94.32579999999999 94.32579999999999 13.07327301328945 50.946;90.3558 36.3081;70.2676 85.0816;103.57 0 Exp 2,3(0.38);Exp 4,1(0.13);Linear,2(0.25);Poly 2,2(0.25) 2.123636535492761 18.745444655418396 1.5528020858764648 5.015069484710693 1.2721117898628158 1.6978691816329956 27.053202399500535 69.23822260049947 19.74445292889218 49.03339707110782 42.6059362520177 92.3498887479823 UP 0.75 0.25 0.0 GO:2001234 7 negative regulation of apoptotic signaling pathway 88 93 4 4 4 4 4 4 92 89 2362 0.72822 0.46851 0.77793 4.3 29142;24471;25599;170465 vnn1;hspb1;cd74;acaa2 VNN1_10157;HSPB1_8847;CD74_8252;ACAA2_7955 58.919399999999996 60.015499999999996 20.7328 33.82359905509761 69.25063869021974 30.077152069194454 37.5505 37.2789 16.8296 17.90521636507082 43.074368168892725 15.972928334443896 76.912275 81.04615 26.7838 40.52909777015153 89.732673860405 34.37644995622836 20.7328;41.6322;94.9138;78.3988 16.8296;30.9494;58.8146;43.6084 26.7838;63.3196;118.773;98.7727 3 1 3 29142;24471;25599 VNN1_10157;HSPB1_8847;CD74_8252 52.42626666666666 41.6322 38.25034766709099 35.5312 30.9494 21.364215985614834 69.62546666666667 63.3196 46.31766612183015 20.7328;41.6322;94.9138 16.8296;30.9494;58.8146 26.7838;63.3196;118.773 1 170465 ACAA2_7955 78.3988 78.3988 43.6084 43.6084 98.7727 98.7727 78.3988 43.6084 98.7727 0 Linear,2(0.5);Poly 2,2(0.5) 2.2223155596809407 9.841776371002197 1.6577342748641968 4.608505725860596 1.4341639251642975 1.7877681851387024 25.77227292600434 92.06652707399564 20.00338796223059 55.09761203776941 37.193759185251515 116.63079081474848 UP 0.75 0.25 0.0 GO:1901605 7 alpha-amino acid metabolic process 67 72 4 4 3 4 3 3 93 69 2382 0.71337 0.51551 0.75143 4.17 293820;114027;25612 psat1;dao;asns PSAT1_9583;DAO_8437;ASNS_8091 20.218166666666665 26.3316 6.1336 12.232907502443295 22.8349483192805 10.437499787269125 15.51079 20.9188 2.43617 11.379129342717745 17.913122459808882 9.70467648599867 29.148500000000002 35.2954 16.2027 11.216130314417715 31.60669209668353 9.58838918329313 26.3316;6.1336;28.1893 20.9188;2.43617;23.1774 35.2954;16.2027;35.9474 3 0 3 293820;114027;25612 PSAT1_9583;DAO_8437;ASNS_8091 20.218166666666665 26.3316 12.232907502443295 15.51079 20.9188 11.379129342717745 29.148500000000002 35.2954 11.216130314417715 26.3316;6.1336;28.1893 20.9188;2.43617;23.1774 35.2954;16.2027;35.9474 0 0 Exp 2,1(0.34);Hill,1(0.34);Linear,1(0.34) 2.6031419858088087 7.9461328983306885 2.0627336502075195 3.2609751224517822 0.5995530876717402 2.6224241256713867 6.3753286852321125 34.061004648101225 2.6340929572431477 28.387487042756852 16.456253721661824 41.84074627833818 UP 1.0 0.0 0.0 GO:0030855 5 epithelial cell differentiation 87 96 6 6 5 6 5 5 91 91 2360 0.84913 0.29403 0.40836 5.21 25123;64305;25664;58868;155423 tagln;sult1b1;pparg;fzd1;anxa7 TAGLN_9981;SULT1B1_32942;PPARG_32510;FZD1_8671;ANXA7_8051 25664(0.0441) 42.31124 45.9044 15.4629 21.50248618725287 38.19829609111054 22.935878718024313 28.748176 35.0852 7.69418 16.987066900788967 25.670191228975188 18.461356854592676 92.60285999999999 101.057 35.0879 41.03347180800088 82.94427727685543 42.88593360468441 3.5 62.47895 45.9044;15.4629;60.1903;25.231;64.7676 35.0852;7.69418;43.9036;13.6792;43.3787 67.7714;35.0879;101.057;131.659;127.439 5 0 5 25123;64305;25664;58868;155423 TAGLN_9981;SULT1B1_32942;PPARG_32510;FZD1_8671;ANXA7_8051 42.31124 45.9044 21.50248618725287 28.748176 35.0852 16.987066900788967 92.60285999999999 101.057 41.03347180800088 45.9044;15.4629;60.1903;25.231;64.7676 35.0852;7.69418;43.9036;13.6792;43.3787 67.7714;35.0879;101.057;131.659;127.439 0 0 Exp 2,2(0.4);Exp 4,1(0.2);Linear,1(0.2);Poly 2,1(0.2) 1.7179518129903517 8.777016997337341 1.5124053955078125 2.5474231243133545 0.4447949380485003 1.5738487243652344 23.463479846420515 61.159000153579484 13.858355359227689 43.637996640772315 56.635436132319654 128.57028386768033 UP 1.0 0.0 0.0 GO:0048878 5 chemical homeostasis 274 291 13 13 9 13 9 9 87 282 2169 0.32672 0.78631 0.62482 3.09 25664;65035;259241;65030;25649;155423;502970;50681;114628 pparg;nr1i3;nr1d2;ephx2;apoa2;anxa7;angptl3;acox1;abcg5 PPARG_32510;NR1I3_32602;NR1D2_9358;EPHX2_33282;APOA2_33095;ANXA7_8051;ANGPTL3_8045;ACOX1_7973;ABCG5_7947 25664(0.0441) 41.22797 33.1119 3.54778 31.431021106807854 39.27581749217283 28.531413270582032 25.595012222222223 24.2098 1.51564 17.53002179794407 25.42013472337839 17.62671784799984 66.66669444444443 55.8619 8.55785 43.44343512126174 66.4098697051457 40.8594545023617 60.1903;22.095;99.0234;6.44145;3.54778;64.7676;58.0729;23.8014;33.1119 43.9036;12.9529;42.5557;2.66377;1.51564;43.3787;40.0757;19.0993;24.2098 101.057;55.8619;102.838;17.3473;8.55785;127.439;105.112;31.3543;50.4329 8 1 8 25664;65035;259241;65030;25649;155423;502970;50681 PPARG_32510;NR1I3_32602;NR1D2_9358;EPHX2_33282;APOA2_33095;ANXA7_8051;ANGPTL3_8045;ACOX1_7973 42.24247875 40.93715 33.443274545451885 25.76816375 29.5875 18.73215207443375 68.69591874999999 78.45945 45.984746459730225 60.1903;22.095;99.0234;6.44145;3.54778;64.7676;58.0729;23.8014 43.9036;12.9529;42.5557;2.66377;1.51564;43.3787;40.0757;19.0993 101.057;55.8619;102.838;17.3473;8.55785;127.439;105.112;31.3543 1 114628 ABCG5_7947 33.1119 33.1119 24.2098 24.2098 50.4329 50.4329 33.1119 24.2098 50.4329 0 Exp 2,2(0.23);Exp 4,1(0.12);Hill,1(0.12);Linear,3(0.34);Poly 2,1(0.12);Power,1(0.12) 1.910426669476844 17.632590174674988 1.5239794254302979 2.7270524501800537 0.47691354210479897 1.7262524366378784 20.69303621021889 61.76290378978112 14.142064647565428 37.04795979687902 38.28365016522011 95.04973872366878 UP 0.8888888888888888 0.1111111111111111 0.0 GO:0071375 6 cellular response to peptide hormone stimulus 102 109 11 11 8 11 8 8 88 101 2350 0.98023 0.050329 0.064158 7.34 286954;78968;24950;25664;24614;58868;114494;65155 ugt2b1;srebf1;srd5a1;pparg;orm1;fzd1;ccna2;alas1 UGT2B10_33303,UGT2B1_33224;SREBF1_32750;SRD5A1_32503;PPARG_32510;ORM1_9400;FZD1_8671;CCNA2_8221;ALAS1_8018 25664(0.0441) 34.07971875 28.1965 12.54415 16.00828210882322 35.617595934257885 16.59486574815821 24.738980625000003 22.22615 7.348245 12.159355325057449 26.111895348807852 12.526421307751189 64.54234375 50.0313 25.495849999999997 38.75656767636235 64.25787098423788 37.21511760087265 4.5 35.2048 12.54415;41.2009;29.2087;60.1903;24.2519;25.231;52.8265;27.1843 7.348245;31.4864;22.9308;43.9036;19.7133;13.6792;37.3288;21.5215 25.495849999999997;60.0774;39.9852;101.057;31.358;131.659;90.0448;36.6615 7 2 6 286954;78968;25664;24614;58868;65155 UGT2B10_33303,UGT2B1_33224;SREBF1_32750;PPARG_32510;ORM1_9400;FZD1_8671;ALAS1_8018 31.76709166666667 26.20765 16.652913123367238 22.942040833333333 20.6174 13.067535564826455 64.38479166666666 48.36945 43.03701487434296 12.54415;41.2009;60.1903;24.2519;25.231;27.1843 7.348245;31.4864;43.9036;19.7133;13.6792;21.5215 25.495849999999997;60.0774;101.057;31.358;131.659;36.6615 2 24950;114494 SRD5A1_32503;CCNA2_8221 41.0176 41.0176 16.700306536707636 30.129800000000003 30.129800000000003 10.180923435523901 65.015 65.015 35.39748262348606 29.2087;52.8265 22.9308;37.3288 39.9852;90.0448 0 Exp 2,3(0.34);Exp 4,1(0.12);Linear,3(0.34);Poly 2,2(0.23) 1.9309021969863058 18.015165209770203 1.5124053955078125 3.5849626064300537 0.6446221555788181 1.8392632007598877 22.986545212389736 45.17289228761026 16.312977271899214 33.164983978100786 37.685412566918245 91.39927493308173 UP 0.75 0.25 0.0 GO:1902532 7 negative regulation of intracellular signal transduction 138 146 4 4 4 4 4 4 92 142 2309 0.34569 0.81228 0.65598 2.74 29142;365813;24471;25599 vnn1;trim59;hspb1;cd74 VNN1_10157;TRIM59_10085;HSPB1_8847;CD74_8252 53.35164999999999 48.879999999999995 20.7328 31.286068278974707 62.470086410068525 29.65732169552916 35.055125000000004 32.28815 16.8296 17.46977597860086 40.03681822335244 16.70414713677873 82.68984999999999 91.0463 26.7838 45.96661735255996 96.76156734623507 38.76216441660478 20.7328;56.1278;41.6322;94.9138 16.8296;33.6269;30.9494;58.8146 26.7838;121.883;63.3196;118.773 3 1 3 29142;24471;25599 VNN1_10157;HSPB1_8847;CD74_8252 52.42626666666666 41.6322 38.25034766709099 35.5312 30.9494 21.364215985614834 69.62546666666667 63.3196 46.31766612183015 20.7328;41.6322;94.9138 16.8296;30.9494;58.8146 26.7838;63.3196;118.773 1 365813 TRIM59_10085 56.1278 56.1278 33.6269 33.6269 121.883 121.883 56.1278 33.6269 121.883 0 Exp 2,1(0.25);Linear,2(0.5);Poly 2,1(0.25) 2.1550897032166945 9.64190399646759 1.528815746307373 4.608505725860596 1.4711623323838265 1.7522912621498108 22.6913030866048 84.0119969133952 17.934744540971153 52.175505459028855 37.64256499449123 127.73713500550875 UP 0.75 0.25 0.0 GO:0051348 6 negative regulation of transferase activity 84 91 7 7 4 7 4 4 92 87 2364 0.74283 0.45154 0.77541 4.4 24679;25664;24471;299626 prkar2b;pparg;hspb1;gadd45b PRKAR2B_33052;PPARG_32510;HSPB1_8847;GADD45B_8679 25664(0.0441) 65.785075 56.38105 41.6322 29.636096184368903 59.7209837867494 22.8387364273894 42.85655 40.5477 30.9494 12.220700947027009 40.7921455219645 9.804904293022332 100.30090000000001 95.2085 63.3196 35.178272266272515 94.77548291649323 28.00136057491743 108.746;60.1903;41.6322;52.5718 59.3814;43.9036;30.9494;37.1918 147.467;101.057;63.3196;89.36 4 0 4 24679;25664;24471;299626 PRKAR2B_33052;PPARG_32510;HSPB1_8847;GADD45B_8679 65.785075 56.38105 29.636096184368903 42.85655 40.5477 12.220700947027009 100.30090000000001 95.2085 35.178272266272515 108.746;60.1903;41.6322;52.5718 59.3814;43.9036;30.9494;37.1918 147.467;101.057;63.3196;89.36 0 0 Exp 2,1(0.25);Linear,2(0.5);Power,1(0.25) 1.631413168925924 6.544429779052734 1.5239794254302979 1.8468482494354248 0.1462400761274278 1.5868010520935059 36.741700739318446 94.82844926068154 30.88026307191354 54.83283692808646 65.8261931790529 134.7756068209471 UP 1.0 0.0 0.0 GO:0003008 3 system process 296 309 6 6 5 6 5 5 91 304 2147 0.017631 0.99391 0.036628 1.62 24679;298490;65030;81633;114628 prkar2b;ppcs;ephx2;acta2;abcg5 PRKAR2B_33052;PPCS_9540;EPHX2_33282;ACTA2_33040;ABCG5_7947 50.75285 33.1119 6.44145 46.03471325138781 43.17991165843059 41.81043608009808 32.892636 24.2098 2.66377 30.45620681569899 28.99771311148495 28.945453107310872 69.88966 50.4329 17.3473 54.3900464729807 60.398422749097534 48.098593362372334 108.746;15.1091;6.44145;90.3558;33.1119 59.3814;7.94061;2.66377;70.2676;24.2098 147.467;30.6311;17.3473;103.57;50.4329 3 2 3 24679;298490;65030 PRKAR2B_33052;PPCS_9540;EPHX2_33282 43.432183333333334 15.1091 56.72920786337346 23.328593333333334 7.94061 31.333925887198262 65.14846666666666 30.6311 71.5986768957593 108.746;15.1091;6.44145 59.3814;7.94061;2.66377 147.467;30.6311;17.3473 2 81633;114628 ACTA2_33040;ABCG5_7947 61.733850000000004 61.733850000000004 40.47754987156461 47.2387 47.2387 32.56778270653377 77.00144999999999 77.00144999999999 37.573603742587714 90.3558;33.1119 70.2676;24.2098 103.57;50.4329 0 Exp 2,1(0.2);Exp 4,1(0.2);Hill,1(0.2);Poly 2,1(0.2);Power,1(0.2) 1.9698232649655052 10.029244303703308 1.600624918937683 2.5319817066192627 0.4288311678869951 1.9018945693969727 10.401644723313105 91.10405527668689 6.196593679535422 59.58867832046458 22.214682244520652 117.56463775547934 UP 0.6 0.4 0.0 GO:0006575 4 cellular modified amino acid metabolic process 61 71 5 5 4 5 4 4 92 67 2384 0.87307 0.27807 0.34093 5.63 29142;64305;680308;311849 vnn1;sult1b1;mthfd2;crat VNN1_10157;SULT1B1_32942;MTHFD2_9261;CRAT_8375 25.649817499999997 18.09785 8.98517 21.717148827640607 21.338101132329324 19.742427467664626 18.222665 12.26189 1.97988 19.7471302306428 13.624630941365393 18.179102373052935 43.25865 33.23025 26.7838 24.590116404834948 40.96258713163491 20.96122022975823 2.5 39.0756 20.7328;15.4629;57.4184;8.98517 16.8296;7.69418;46.387;1.97988 26.7838;35.0879;79.7903;31.3726 4 0 4 29142;64305;680308;311849 VNN1_10157;SULT1B1_32942;MTHFD2_9261;CRAT_8375 25.649817499999997 18.09785 21.717148827640607 18.222665 12.26189 19.7471302306428 43.25865 33.23025 24.590116404834948 20.7328;15.4629;57.4184;8.98517 16.8296;7.69418;46.387;1.97988 26.7838;35.0879;79.7903;31.3726 0 0 Exp 2,1(0.25);Exp 4,1(0.25);Hill,1(0.25);Linear,1(0.25) 2.1150074534468732 9.507079362869263 1.5558284521102905 4.608505725860596 1.4894261682112306 1.6713725924491882 4.367011648912207 46.9326233510878 -1.1295226260299387 37.57485262602994 19.160335923261744 67.35696407673827 UP 1.0 0.0 0.0 GO:0042981 7 regulation of apoptotic process 428 455 15 15 11 15 11 11 85 444 2007 0.057089 0.97018 0.10347 2.42 29142;360243;25664;24484;63868;24471;299626;25599;25612;50559;170465 vnn1;top2a;pparg;igfbp3;hspd1;hspb1;gadd45b;cd74;asns;acot1;acaa2 VNN1_10157;TOP2A_10059;PPARG_32510;IGFBP3_8881;HSPD1_8849;HSPB1_8847;GADD45B_8679;CD74_8252;ASNS_8091;ACOT1_7968;ACAA2_7955 25664(0.0441) 49.59014545454545 50.946 20.7328 22.502745866332127 56.15771255828412 22.070455903256388 32.822472727272725 30.9494 16.8296 12.636819583272596 36.735340838964056 12.572530579662125 83.59727272727274 85.0816 26.7838 54.46924259113746 91.85528714559166 47.32236585548642 20.7328;54.9577;60.1903;50.946;34.4455;41.6322;52.5718;94.9138;28.1893;28.5134;78.3988 16.8296;18.8326;43.9036;36.3081;26.6907;30.9494;37.1918;58.8146;23.1774;24.741;43.6084 26.7838;218.525;101.057;85.0816;48.4857;63.3196;89.36;118.773;35.9474;33.4642;98.7727 8 3 8 29142;25664;63868;24471;299626;25599;25612;50559 VNN1_10157;PPARG_32510;HSPD1_8849;HSPB1_8847;GADD45B_8679;CD74_8252;ASNS_8091;ACOT1_7968 45.14863749999999 38.03885 24.03964645538329 32.7872625 28.820050000000002 13.483745824291832 64.6488375 55.90265 34.555648487370036 20.7328;60.1903;34.4455;41.6322;52.5718;94.9138;28.1893;28.5134 16.8296;43.9036;26.6907;30.9494;37.1918;58.8146;23.1774;24.741 26.7838;101.057;48.4857;63.3196;89.36;118.773;35.9474;33.4642 3 360243;24484;170465 TOP2A_10059;IGFBP3_8881;ACAA2_7955 61.43416666666667 54.9577 14.828099079900037 32.91636666666667 36.3081 12.731376895816632 134.12643333333332 98.7727 73.41117146826721 54.9577;50.946;78.3988 18.8326;36.3081;43.6084 218.525;85.0816;98.7727 0 Exp 2,5(0.46);Linear,4(0.37);Poly 2,2(0.19) 2.6730487609813602 72.26750469207764 1.5239794254302979 50.888092041015625 14.729542880513211 1.7380040884017944 36.29187245536042 62.888418453730495 25.35458957834402 40.29035587620143 51.408007366571695 115.78653808797375 UP 0.7272727272727273 0.2727272727272727 0.0 GO:0006259 5 DNA metabolic process 110 119 6 6 6 6 6 6 90 113 2338 0.84149 0.29048 0.45374 5.04 360243;291234;316273;293502;63868;362485 top2a;mki67;mcm3;kif22;hspd1;ccne2 TOP2A_10059;MKI67_9232;MCM3_9207;KIF22_8963;HSPD1_8849;CCNE2_8227 57.49945 54.4811 34.4455 16.09356440043658 56.14143594707181 14.902714055944465 35.212799999999994 34.46275 18.8326 11.78948329605672 34.48137878889978 10.753191079925307 135.29256666666666 138.5845 48.4857 65.2217137156842 129.0051695632198 60.8876593764969 4.5 75.9034 54.9577;49.7822;54.0045;73.9175;34.4455;77.8893 18.8326;35.6665;33.259;47.5608;26.6907;49.2672 218.525;82.1147;111.753;165.416;48.4857;185.461 1 5 1 63868 HSPD1_8849 34.4455 34.4455 26.6907 26.6907 48.4857 48.4857 34.4455 26.6907 48.4857 5 360243;291234;316273;293502;362485 TOP2A_10059;MKI67_9232;MCM3_9207;KIF22_8963;CCNE2_8227 62.11024 54.9577 12.818273507302024 36.91722 35.6665 12.326882775543872 152.65393999999998 165.416 55.28752386269444 54.9577;49.7822;54.0045;73.9175;77.8893 18.8326;35.6665;33.259;47.5608;49.2672 218.525;82.1147;111.753;165.416;185.461 0 Exp 2,3(0.5);Linear,3(0.5) 1.8206075510338897 11.016477465629578 1.589782476425171 2.285626173019409 0.2690133439329217 1.7322618961334229 44.621916498261285 70.37698350173872 25.779248653907864 44.64635134609214 83.10432654058563 187.48080679274773 DOWN 0.16666666666666666 0.8333333333333334 0.0 GO:0000038 7 very long-chain fatty acid metabolic process 10 12 5 5 5 5 5 5 91 7 2444 1.0 4.4032E-5 4.4032E-5 41.67 50681;681337;314304;192272;50559 acox1;acot4;acot3;acot2;acot1 ACOX1_7973;ACOT4_7971;ACOT3_7970;ACOT2_7969;ACOT1_7968 21.830099999999998 23.8014 12.3157 8.488018185065348 18.559795207823967 8.010705256607839 17.31149 19.0993 6.70485 8.079882481849594 14.782676778728607 7.430731990465804 29.488419999999998 31.3543 16.9658 9.226839545965893 24.867140299511007 9.418812238541008 0.0 12.3157 0.5 12.975950000000001 23.8014;12.3157;30.8838;13.6362;28.5134 19.0993;6.70485;24.6874;11.3249;24.741 31.3543;24.3993;41.2585;16.9658;33.4642 5 0 5 50681;681337;314304;192272;50559 ACOX1_7973;ACOT4_7971;ACOT3_7970;ACOT2_7969;ACOT1_7968 21.830099999999998 23.8014 8.488018185065348 17.31149 19.0993 8.079882481849594 29.488419999999998 31.3543 9.226839545965893 23.8014;12.3157;30.8838;13.6362;28.5134 19.0993;6.70485;24.6874;11.3249;24.741 31.3543;24.3993;41.2585;16.9658;33.4642 0 0 Exp 2,2(0.4);Hill,1(0.2);Linear,2(0.4) 4.751938139573742 62.15936839580536 1.5733836889266968 50.888092041015625 21.523784548559536 2.8540289402008057 14.390024022824285 29.270175977175718 10.229160739986838 24.39381926001316 21.400738546632898 37.5761014533671 UP 1.0 0.0 0.0 GO:0048015 7 phosphatidylinositol-mediated signaling 19 20 1 1 1 1 1 1 95 19 2432 0.82744 0.53761 0.53761 5.0 25685 igfbp1 IGFBP1_32306 98.8371 98.8371 98.8371 98.8371 57.328 57.328 57.328 57.32800000000001 357.409 357.409 357.409 357.409 0.0 98.8371 98.8371 57.328 357.409 1 0 1 25685 IGFBP1_32306 98.8371 98.8371 57.328 57.328 357.409 357.409 98.8371 57.328 357.409 0 0 Linear,1(1) 2.031935214996338 2.031935214996338 2.031935214996338 2.031935214996338 0.0 2.031935214996338 98.8371 98.8371 57.328 57.328 357.409 357.409 UP 1.0 0.0 0.0 GO:0032879 4 regulation of localization 652 690 25 25 18 24 18 18 78 672 1779 0.035981 0.97994 0.061703 2.61 361604;78968;309607;25664;296371;24614;24484;63868;24471;25427;65210;25599;362485;25649;502970;81633;170465;114628 sytl2;srebf1;rt1-ce5;pparg;pltp;orm1;igfbp3;hspd1;hspb1;cyp51;cyp2j4;cd74;ccne2;apoa2;angptl3;acta2;acaa2;abcg5 SYTL2_32351;SREBF1_32750;RT1-CE5_32445;PPARG_32510;PLTP_32412;ORM1_9400;IGFBP3_8881;HSPD1_8849;HSPB1_8847;CYP51_8429;CYP2J4_32580;CD74_8252;CCNE2_8227;APOA2_33095;ANGPTL3_8045;ACTA2_33040;ACAA2_7955;ABCG5_7947 25664(0.0441) 54.96001555555555 56.446749999999994 3.54778 26.461201835955592 52.7682692030788 26.51846590739461 36.711130000000004 38.191900000000004 1.51564 17.53487655682977 35.35868094189971 17.459437595275705 92.02849722222223 99.91485 8.55785 48.85530764981206 84.42581114056465 42.742138526038715 67.0093;41.2009;54.8206;60.1903;87.0256;24.2519;50.946;34.4455;41.6322;75.1522;16.3155;94.9138;77.8893;3.54778;58.0729;90.3558;78.3988;33.1119 44.4373;31.4864;26.5902;43.9036;56.6266;19.7133;36.3081;26.6907;30.9494;48.098;8.2378;58.8146;49.2672;1.51564;40.0757;70.2676;43.6084;24.2098 135.846;60.0774;147.824;101.057;104.563;31.358;85.0816;48.4857;63.3196;171.379;36.8422;118.773;185.461;8.55785;105.112;103.57;98.7727;50.4329 10 8 10 78968;25664;296371;24614;63868;24471;65210;25599;25649;502970 SREBF1_32750;PPARG_32510;PLTP_32412;ORM1_9400;HSPD1_8849;HSPB1_8847;CYP2J4_32580;CD74_8252;APOA2_33095;ANGPTL3_8045 46.159637999999994 41.41655 29.35317559212284 31.801374 31.2179 18.87522733767682 67.814575 61.698499999999996 37.559978652766155 41.2009;60.1903;87.0256;24.2519;34.4455;41.6322;16.3155;94.9138;3.54778;58.0729 31.4864;43.9036;56.6266;19.7133;26.6907;30.9494;8.2378;58.8146;1.51564;40.0757 60.0774;101.057;104.563;31.358;48.4857;63.3196;36.8422;118.773;8.55785;105.112 8 361604;309607;24484;25427;362485;81633;170465;114628 SYTL2_32351;RT1-CE5_32445;IGFBP3_8881;CYP51_8429;CCNE2_8227;ACTA2_33040;ACAA2_7955;ABCG5_7947 65.9604875 71.08075 18.5406452074846 42.848325 44.022850000000005 14.5316208254128 122.2959 119.708 45.80621421625802 67.0093;54.8206;50.946;75.1522;77.8893;90.3558;78.3988;33.1119 44.4373;26.5902;36.3081;48.098;49.2672;70.2676;43.6084;24.2098 135.846;147.824;85.0816;171.379;185.461;103.57;98.7727;50.4329 0 Exp 2,6(0.34);Exp 4,1(0.06);Hill,1(0.06);Linear,6(0.34);Poly 2,4(0.23) 1.7921178179102333 33.076993346214294 1.5084086656570435 3.5849626064300537 0.4978326578883839 1.6919933557510376 42.73556398794281 67.18446712316829 28.610430321205808 44.8118296787942 69.4584965892793 114.59849785516515 CONFLICT 0.5555555555555556 0.4444444444444444 0.0 GO:0003006 3 developmental process involved in reproduction 220 234 6 6 5 6 5 5 91 229 2222 0.11065 0.95004 0.20746 2.14 24950;25664;25626;50549;50681 srd5a1;pparg;krt8;cyp4a1;acox1 SRD5A1_32503;PPARG_32510;KRT8_8978;CYP4A1_33111;ACOX1_7973 25664(0.0441) 41.07246 29.2087 23.208 21.80048020510099 53.18063202987329 19.85540076361307 30.026819999999997 22.9308 18.863 13.429202817814623 37.60095438449274 12.074110418520249 69.19196 39.9852 29.9853 50.91794686898718 96.16402246370731 48.39109476634734 29.2087;60.1903;68.9539;23.208;23.8014 22.9308;43.9036;45.3374;18.863;19.0993 39.9852;101.057;143.578;29.9853;31.3543 4 1 4 25664;25626;50549;50681 PPARG_32510;KRT8_8978;CYP4A1_33111;ACOX1_7973 44.0384 41.995850000000004 23.97990649842767 31.800825 31.50145 14.814768290318728 76.49365 66.20565 55.69038132475541 60.1903;68.9539;23.208;23.8014 43.9036;45.3374;18.863;19.0993 101.057;143.578;29.9853;31.3543 1 24950 SRD5A1_32503 29.2087 29.2087 22.9308 22.9308 39.9852 39.9852 29.2087 22.9308 39.9852 0 Exp 2,2(0.4);Linear,3(0.6) 1.7235260334982159 8.682601928710938 1.5239794254302979 2.0425233840942383 0.24114245155404837 1.5914322137832642 21.963496573148205 60.181423426851794 18.255604729368038 41.79803527063196 24.56041173427907 113.82350826572092 UP 0.8 0.2 0.0 GO:0050769 7 positive regulation of neurogenesis 132 142 4 4 3 4 3 3 93 139 2312 0.20551 0.91262 0.36855 2.11 25664;24471;58868 pparg;hspb1;fzd1 PPARG_32510;HSPB1_8847;FZD1_8671 25664(0.0441) 42.35116666666667 41.6322 25.231 17.490736088665123 46.00298883836514 17.403448984844562 29.51073333333333 30.9494 13.6792 15.163472892887478 32.579824343044464 14.790148158468376 98.67853333333333 101.057 63.3196 34.23172835036719 97.02126368106592 31.136446936567697 60.1903;41.6322;25.231 43.9036;30.9494;13.6792 101.057;63.3196;131.659 3 0 3 25664;24471;58868 PPARG_32510;HSPB1_8847;FZD1_8671 42.35116666666667 41.6322 17.490736088665123 29.51073333333333 30.9494 15.163472892887478 98.67853333333333 101.057 34.23172835036719 60.1903;41.6322;25.231 43.9036;30.9494;13.6792 101.057;63.3196;131.659 0 0 Exp 2,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 1.6206634755448701 4.883233070373535 1.5124053955078125 1.8468482494354248 0.1898377632902836 1.5239794254302979 22.55853553600024 62.14379779733309 12.351648426479304 46.669818240187354 59.94168608062847 137.4153805860382 UP 1.0 0.0 0.0 GO:0042752 4 regulation of circadian rhythm 33 35 5 4 4 5 3 3 93 32 2419 0.95943 0.14305 0.14305 8.57 360243;25664;259241 top2a;pparg;nr1d2 TOP2A_10059;PPARG_32510;NR1D2_9358 25664(0.0441) 71.39046666666667 60.1903 54.9577 24.073414364051768 66.98061034627366 20.544054812867753 35.0973 42.5557 18.8326 14.10175727241112 36.68153003235082 13.534557628532985 140.80666666666664 102.838 101.057 67.31194167704079 133.93345249221184 64.0784068168784 0.5 57.574 54.9577;60.1903;99.0234 18.8326;43.9036;42.5557 218.525;101.057;102.838 2 1 2 25664;259241 PPARG_32510;NR1D2_9358 79.60685 79.60685 27.45914834449535 43.22965 43.22965 0.9531092303614551 101.94749999999999 101.94749999999999 1.2593571772946877 60.1903;99.0234 43.9036;42.5557 101.057;102.838 1 360243 TOP2A_10059 54.9577 54.9577 18.8326 18.8326 218.525 218.525 54.9577 18.8326 218.525 0 Exp 2,2(0.67);Power,1(0.34) 1.957966621905616 6.057137966156006 1.5239794254302979 2.7270524501800537 0.6291690757622961 1.8061060905456543 44.14883383040525 98.63209950292809 19.139659419744284 51.05494058025571 64.63603407871157 216.97729925462176 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0043434 5 response to peptide hormone 194 204 13 13 10 13 10 10 86 194 2257 0.85864 0.23566 0.33997 4.9 286954;78968;24950;25664;24614;24484;24471;58868;114494;65155 ugt2b1;srebf1;srd5a1;pparg;orm1;igfbp3;hspb1;fzd1;ccna2;alas1 UGT2B10_33303,UGT2B1_33224;SREBF1_32750;SRD5A1_32503;PPARG_32510;ORM1_9400;IGFBP3_8881;HSPB1_8847;FZD1_8671;CCNA2_8221;ALAS1_8018 25664(0.0441) 36.521595 35.2048 12.54415 15.186761386016624 37.489162362779176 15.515205290557557 26.5169345 26.9401 7.348245 11.429747180819788 27.439825896968237 11.617200769136343 66.47399499999999 61.698499999999996 25.495849999999997 34.80189035483921 65.89682576310265 33.73603870822475 12.54415;41.2009;29.2087;60.1903;24.2519;50.946;41.6322;25.231;52.8265;27.1843 7.348245;31.4864;22.9308;43.9036;19.7133;36.3081;30.9494;13.6792;37.3288;21.5215 25.495849999999997;60.0774;39.9852;101.057;31.358;85.0816;63.3196;131.659;90.0448;36.6615 8 3 7 286954;78968;25664;24614;24471;58868;65155 UGT2B10_33303,UGT2B1_33224;SREBF1_32750;PPARG_32510;ORM1_9400;HSPB1_8847;FZD1_8671;ALAS1_8018 33.17639285714286 27.1843 15.652555866812625 24.08594928571429 21.5215 12.306912310310413 64.23262142857142 60.0774 39.28930259262541 12.54415;41.2009;60.1903;24.2519;41.6322;25.231;27.1843 7.348245;31.4864;43.9036;19.7133;30.9494;13.6792;21.5215 25.495849999999997;60.0774;101.057;31.358;63.3196;131.659;36.6615 3 24950;24484;114494 SRD5A1_32503;IGFBP3_8881;CCNA2_8221 44.32706666666667 50.946 13.126607637288968 32.189233333333334 36.3081 8.034263996367907 71.70386666666667 85.0816 27.581038774733106 29.2087;50.946;52.8265 22.9308;36.3081;37.3288 39.9852;85.0816;90.0448 0 Exp 2,3(0.28);Exp 4,1(0.1);Linear,5(0.46);Poly 2,2(0.19) 1.9047925397461012 21.600017547607422 1.5124053955078125 3.5849626064300537 0.5832564169769534 1.8392632007598877 27.1087427727836 45.934447227216396 19.432703802429327 33.60116519757067 44.90355988145548 88.04443011854453 UP 0.7 0.3 0.0 GO:1903532 6 positive regulation of secretion by cell 132 141 4 4 4 4 4 4 92 137 2314 0.37694 0.78984 0.8184 2.84 309607;24614;63868;65210 rt1-ce5;orm1;hspd1;cyp2j4 RT1-CE5_32445;ORM1_9400;HSPD1_8849;CYP2J4_32580 32.458375000000004 29.3487 16.3155 16.652891820016322 30.263899059352074 16.52317500248245 20.308 23.15175 8.2378 8.684244205456228 18.887844944017406 8.998750838763652 66.127475 42.66395 31.358 54.93055660203314 61.4363359060756 52.62419761500367 54.8206;24.2519;34.4455;16.3155 26.5902;19.7133;26.6907;8.2378 147.824;31.358;48.4857;36.8422 3 1 3 24614;63868;65210 ORM1_9400;HSPD1_8849;CYP2J4_32580 25.0043 24.2519 9.088388433600315 18.213933333333333 19.7133 9.317373820091865 38.8953 36.8422 8.746481665789943 24.2519;34.4455;16.3155 19.7133;26.6907;8.2378 31.358;48.4857;36.8422 1 309607 RT1-CE5_32445 54.8206 54.8206 26.5902 26.5902 147.824 147.824 54.8206 26.5902 147.824 0 Exp 2,3(0.75);Exp 4,1(0.25) 2.1478146303827734 9.028750538825989 1.6557694673538208 3.5849626064300537 0.8930856497720426 1.8940092325210571 16.138541016383996 48.778208983616 11.797440678652903 28.818559321347095 12.295529530007528 119.95942046999248 UP 0.75 0.25 0.0 GO:0019219 6 regulation of nucleobase-containing compound metabolic process 550 589 18 17 13 18 12 12 84 577 1874 0.0058532 0.99749 0.0095379 2.04 360243;78968;25664;363465;54133;65035;259241;24484;58868;306575;25599;114494 top2a;srebf1;pparg;pir;pdlim1;nr1i3;nr1d2;igfbp3;fzd1;ckap2;cd74;ccna2 TOP2A_10059;SREBF1_32750;PPARG_32510;PIR_9487;PDLIM1_9452;NR1I3_32602;NR1D2_9358;IGFBP3_8881;FZD1_8671;CKAP2_8324;CD74_8252;CCNA2_8221 25664(0.0441) 57.07275833333333 53.8921 22.095 23.212010240251935 57.11563440544924 22.197292528192655 35.598458333333326 39.1466 12.9529 14.051786149063599 37.11540431268245 14.016743191963887 107.34820000000002 101.94749999999999 55.8619 43.14479475206921 104.19533934219918 40.2205127796514 54.9577;41.2009;60.1903;52.1607;67.1147;22.095;99.0234;50.946;25.231;64.2131;94.9138;52.8265 18.8326;31.4864;43.9036;40.9644;47.2419;12.9529;42.5557;36.3081;13.6792;43.1133;58.8146;37.3288 218.525;60.0774;101.057;74.9097;123.914;55.8619;102.838;85.0816;131.659;125.437;118.773;90.0448 8 4 8 78968;25664;363465;54133;65035;259241;58868;25599 SREBF1_32750;PPARG_32510;PIR_9487;PDLIM1_9452;NR1I3_32602;NR1D2_9358;FZD1_8671;CD74_8252 57.741225 56.1755 28.8151026955236 36.449837499999994 41.76005 16.147164003001325 96.13625 101.94749999999999 29.24734225522524 41.2009;60.1903;52.1607;67.1147;22.095;99.0234;25.231;94.9138 31.4864;43.9036;40.9644;47.2419;12.9529;42.5557;13.6792;58.8146 60.0774;101.057;74.9097;123.914;55.8619;102.838;131.659;118.773 4 360243;24484;306575;114494 TOP2A_10059;IGFBP3_8881;CKAP2_8324;CCNA2_8221 55.735825000000006 53.8921 5.884336989769191 33.895700000000005 36.81845 10.479614826573203 129.7721 107.7409 61.83680000873266 54.9577;50.946;64.2131;52.8265 18.8326;36.3081;43.1133;37.3288 218.525;85.0816;125.437;90.0448 0 Exp 2,5(0.42);Linear,3(0.25);Poly 2,3(0.25);Power,1(0.09) 1.9131607563669022 23.395803213119507 1.5124053955078125 2.7270524501800537 0.4110506386313131 1.8319215774536133 43.93932717990437 70.2061894867623 27.64791186789156 43.54900479877511 82.93673431304644 131.75966568695358 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0022603 5 regulation of anatomical structure morphogenesis 271 280 7 7 6 7 6 6 90 274 2177 0.082032 0.96247 0.18048 2.14 25664;24471;29455;58868;155423;502970 pparg;hspb1;gdf15;fzd1;anxa7;angptl3 PPARG_32510;HSPB1_8847;GDF15_33113;FZD1_8671;ANXA7_8051;ANGPTL3_8045 25664(0.0441) 45.209900000000005 49.852549999999994 21.3654 18.723724764052687 50.15591142443294 15.252990421040966 31.645683333333334 35.51255 13.6792 13.202668855866472 35.11833183863413 11.618016660967186 92.48989999999999 103.08449999999999 26.3528 40.529971613461555 99.09562022928993 27.901323661175592 60.1903;41.6322;21.3654;25.231;64.7676;58.0729 43.9036;30.9494;17.8875;13.6792;43.3787;40.0757 101.057;63.3196;26.3528;131.659;127.439;105.112 6 0 6 25664;24471;29455;58868;155423;502970 PPARG_32510;HSPB1_8847;GDF15_33113;FZD1_8671;ANXA7_8051;ANGPTL3_8045 45.209900000000005 49.852549999999994 18.723724764052687 31.645683333333334 35.51255 13.202668855866472 92.48989999999999 103.08449999999999 40.529971613461555 60.1903;41.6322;21.3654;25.231;64.7676;58.0729 43.9036;30.9494;17.8875;13.6792;43.3787;40.0757 101.057;63.3196;26.3528;131.659;127.439;105.112 0 0 Exp 2,2(0.34);Linear,3(0.5);Poly 2,1(0.17) 1.929863634655147 13.009743809700012 1.5124053955078125 5.015069484710693 1.4002813069531521 1.5557206273078918 30.227799892960807 60.192000107039206 21.081348032996104 42.210018633670565 60.05916841746063 124.92063158253939 UP 1.0 0.0 0.0 GO:0071348 7 cellular response to interleukin-11 1 1 1 1 1 1 1 1 95 0 2451 1.0 0.037691 0.037691 100.0 24471 hspb1 HSPB1_8847 41.6322 41.6322 41.6322 41.6322 30.9494 30.9494 30.9494 30.9494 63.3196 63.3196 63.3196 63.31960000000001 0.0 41.6322 0.0 41.6322 41.6322 30.9494 63.3196 1 0 1 24471 HSPB1_8847 41.6322 41.6322 30.9494 30.9494 63.3196 63.3196 41.6322 30.9494 63.3196 0 0 Linear,1(1) 1.8468482494354248 1.8468482494354248 1.8468482494354248 1.8468482494354248 0.0 1.8468482494354248 41.6322 41.6322 30.9494 30.9494 63.3196 63.3196 UP 1.0 0.0 0.0 GO:1903545 7 cellular response to butyrate 1 1 1 1 1 1 1 1 95 0 2451 1.0 0.037691 0.037691 100.0 24471 hspb1 HSPB1_8847 41.6322 41.6322 41.6322 41.6322 30.9494 30.9494 30.9494 30.9494 63.3196 63.3196 63.3196 63.31960000000001 0.0 41.6322 0.0 41.6322 41.6322 30.9494 63.3196 1 0 1 24471 HSPB1_8847 41.6322 41.6322 30.9494 30.9494 63.3196 63.3196 41.6322 30.9494 63.3196 0 0 Linear,1(1) 1.8468482494354248 1.8468482494354248 1.8468482494354248 1.8468482494354248 0.0 1.8468482494354248 41.6322 41.6322 30.9494 30.9494 63.3196 63.3196 UP 1.0 0.0 0.0 GO:0016101 7 diterpenoid metabolic process 22 26 5 5 3 5 3 3 93 23 2428 0.98502 0.07211 0.07211 11.54 24950;65210;499353 srd5a1;cyp2j4;cyp2c24 SRD5A1_32503;CYP2J4_32580;CYP2C24_32875 34.82256666666667 29.2087 16.3155 21.86145512570773 33.953724197236305 23.431903064839993 26.439700000000002 22.9308 8.2378 20.18638624741932 25.263488368625115 21.820674338886022 52.4147 39.9852 36.8422 24.301308920508806 52.91544917983895 25.01782295745121 0.5 22.7621 1.5 44.0761 29.2087;16.3155;58.9435 22.9308;8.2378;48.1505 39.9852;36.8422;80.4167 2 1 2 65210;499353 CYP2J4_32580;CYP2C24_32875 37.6295 37.6295 30.142547868420145 28.19415 28.19415 28.22254082546432 58.629450000000006 58.629450000000006 30.811824436813215 16.3155;58.9435 8.2378;48.1505 36.8422;80.4167 1 24950 SRD5A1_32503 29.2087 29.2087 22.9308 22.9308 39.9852 39.9852 29.2087 22.9308 39.9852 0 Exp 2,1(0.34);Exp 4,1(0.34);Linear,1(0.34) 2.1692427880515104 6.587609648704529 1.940477728843689 2.6958487033843994 0.4330280653021715 1.9512832164764404 10.084001343326264 59.56113199000707 3.5966535535299187 49.282746446470085 24.915180196044634 79.91421980395538 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0046677 4 response to antibiotic 202 218 10 10 8 9 7 7 89 211 2240 0.41263 0.72872 0.85195 3.21 286954;78968;24950;63868;24471;25086;65155 ugt2b1;srebf1;srd5a1;hspd1;hspb1;cyp2e1;alas1 UGT2B10_33303,UGT2B1_33224;SREBF1_32750;SRD5A1_32503;HSPD1_8849;HSPB1_8847;CYP2E1_8421;ALAS1_8018 27.729641428571426 29.2087 7.89174 13.206596793711885 29.373744046413062 13.441342795673544 20.727859285714285 22.9308 4.16797 10.912595071921261 21.9766285685859 11.05887550472168 41.404735714285714 39.9852 15.8079 17.37754170063367 43.90398472451933 17.774340783005368 12.54415;41.2009;29.2087;34.4455;41.6322;7.89174;27.1843 7.348245;31.4864;22.9308;26.6907;30.9494;4.16797;21.5215 25.495849999999997;60.0774;39.9852;48.4857;63.3196;15.8079;36.6615 7 1 6 286954;78968;63868;24471;25086;65155 UGT2B10_33303,UGT2B1_33224;SREBF1_32750;HSPD1_8849;HSPB1_8847;CYP2E1_8421;ALAS1_8018 27.48313166666667 30.8149 14.449449654544507 20.3607025 24.106099999999998 11.906692360180367 41.641325 42.5736 19.02378934260338 12.54415;41.2009;34.4455;41.6322;7.89174;27.1843 7.348245;31.4864;26.6907;30.9494;4.16797;21.5215 25.495849999999997;60.0774;48.4857;63.3196;15.8079;36.6615 1 24950 SRD5A1_32503 29.2087 29.2087 22.9308 22.9308 39.9852 39.9852 29.2087 22.9308 39.9852 0 Exp 2,2(0.25);Exp 4,2(0.25);Linear,3(0.38);Poly 2,1(0.13) 1.757207833331309 14.101847648620605 1.5310101509094238 1.9512832164764404 0.14803066119153183 1.7845460772514343 17.94605760970533 37.51322524743752 12.643695724491536 28.812022846937033 28.531272667776996 54.27819876079442 UP 0.8571428571428571 0.14285714285714285 0.0 GO:0019222 4 regulation of metabolic process 1092 1179 49 48 35 48 34 34 62 1145 1306 0.018424 0.9893 0.036416 2.88 360243;361604;78968;84386;299270;309607;24679;25664;363465;54133;24614;65035;259241;24552;24484;63868;24471;29455;299626;58868;65030;117543;25427;65210;25413;306575;64515;25599;362485;114494;25649;155423;502970;81633 top2a;sytl2;srebf1;slpi;serpina6;rt1-ce5;prkar2b;pparg;pir;pdlim1;orm1;nr1i3;nr1d2;me1;igfbp3;hspd1;hspb1;gdf15;gadd45b;fzd1;ephx2;decr1;cyp51;cyp2j4;cpt2;ckap2;cdc20;cd74;ccne2;ccna2;apoa2;anxa7;angptl3;acta2 TOP2A_10059;SYTL2_32351;SREBF1_32750;SLPI_9890;SERPINA6_32325;RT1-CE5_32445;PRKAR2B_33052;PPARG_32510;PIR_9487;PDLIM1_9452;ORM1_9400;NR1I3_32602;NR1D2_9358;ME1_9215;IGFBP3_8881;HSPD1_8849;HSPB1_8847;GDF15_33113;GADD45B_8679;FZD1_8671;EPHX2_33282;DECR1_8458;CYP51_8429;CYP2J4_32580;CPT2_8374;CKAP2_8324;CDC20_8255;CD74_8252;CCNE2_8227;CCNA2_8221;APOA2_33095;ANXA7_8051;ANGPTL3_8045;ACTA2_33040 25664(0.0441) 53.18018323529413 53.2847 3.54778 27.20875661188 51.16004507300846 25.554303219132212 34.047359117647055 37.07985 1.51564 16.33927995342186 33.39996410228302 15.951496231959133 103.53592205882353 91.29390000000001 8.55785 79.1879143261995 96.14048174646109 71.70649688078453 54.9577;67.0093;41.2009;53.7429;68.3847;54.8206;108.746;60.1903;52.1607;67.1147;24.2519;22.095;99.0234;49.3339;50.946;34.4455;41.6322;21.3654;52.5718;25.231;6.44145;21.6199;75.1522;16.3155;31.2175;64.2131;101.569;94.9138;77.8893;52.8265;3.54778;64.7676;58.0729;90.3558 18.8326;44.4373;31.4864;37.8192;36.9679;26.5902;59.3814;43.9036;40.9644;47.2419;19.7133;12.9529;42.5557;35.4173;36.3081;26.6907;30.9494;17.8875;37.1918;13.6792;2.66377;17.4928;48.098;8.2378;24.8356;43.1133;51.5499;58.8146;49.2672;37.3288;1.51564;43.3787;40.0757;70.2676 218.525;135.846;60.0774;92.543;89.5095;147.824;147.467;101.057;74.9097;123.914;31.358;55.8619;102.838;80.9924;85.0816;48.4857;63.3196;26.3528;89.36;131.659;17.3473;28.0829;171.379;36.8422;42.0237;125.437;453.17;118.773;185.461;90.0448;8.55785;127.439;105.112;103.57 23 11 23 78968;299270;24679;25664;363465;54133;24614;65035;259241;24552;63868;24471;29455;299626;58868;65030;117543;65210;25413;25599;25649;155423;502970 SREBF1_32750;SERPINA6_32325;PRKAR2B_33052;PPARG_32510;PIR_9487;PDLIM1_9452;ORM1_9400;NR1I3_32602;NR1D2_9358;ME1_9215;HSPD1_8849;HSPB1_8847;GDF15_33113;GADD45B_8679;FZD1_8671;EPHX2_33282;DECR1_8458;CYP2J4_32580;CPT2_8374;CD74_8252;APOA2_33095;ANXA7_8051;ANGPTL3_8045 46.28886217391305 41.6322 28.760055750051837 30.17382652173913 31.4864 16.390581715993214 74.4060847826087 74.9097 40.736420902747206 41.2009;68.3847;108.746;60.1903;52.1607;67.1147;24.2519;22.095;99.0234;49.3339;34.4455;41.6322;21.3654;52.5718;25.231;6.44145;21.6199;16.3155;31.2175;94.9138;3.54778;64.7676;58.0729 31.4864;36.9679;59.3814;43.9036;40.9644;47.2419;19.7133;12.9529;42.5557;35.4173;26.6907;30.9494;17.8875;37.1918;13.6792;2.66377;17.4928;8.2378;24.8356;58.8146;1.51564;43.3787;40.0757 60.0774;89.5095;147.467;101.057;74.9097;123.914;31.358;55.8619;102.838;80.9924;48.4857;63.3196;26.3528;89.36;131.659;17.3473;28.0829;36.8422;42.0237;118.773;8.55785;127.439;105.112 11 360243;361604;84386;309607;24484;25427;306575;64515;362485;114494;81633 TOP2A_10059;SYTL2_32351;SLPI_9890;RT1-CE5_32445;IGFBP3_8881;CYP51_8429;CKAP2_8324;CDC20_8255;CCNE2_8227;CCNA2_8221;ACTA2_33040 67.58930909090908 64.2131 16.90330034972193 42.14656363636363 43.1133 13.53915233825758 164.44376363636366 135.846 104.9294579109153 54.9577;67.0093;53.7429;54.8206;50.946;75.1522;64.2131;101.569;77.8893;52.8265;90.3558 18.8326;44.4373;37.8192;26.5902;36.3081;48.098;43.1133;51.5499;49.2672;37.3288;70.2676 218.525;135.846;92.543;147.824;85.0816;171.379;125.437;453.17;185.461;90.0448;103.57 0 Exp 2,11(0.33);Exp 4,2(0.06);Hill,1(0.03);Linear,13(0.39);Poly 2,5(0.15);Power,2(0.06) 1.8856697171433225 66.68309342861176 1.512166976928711 5.015069484710693 0.6886478208955475 1.7720550894737244 44.03430724094247 62.32605922964575 28.555118864899015 39.539599370395095 76.91791613485783 130.15392798278918 UP 0.6764705882352942 0.3235294117647059 0.0 GO:0035999 6 tetrahydrofolate interconversion 3 3 1 1 1 1 1 1 95 2 2449 0.99588 0.10891 0.10891 33.33 680308 mthfd2 MTHFD2_9261 57.4184 57.4184 57.4184 57.4184 46.387 46.387 46.387 46.387 79.7903 79.7903 79.7903 79.7903 0.0 57.4184 0.0 57.4184 57.4184 46.387 79.7903 1 0 1 680308 MTHFD2_9261 57.4184 57.4184 46.387 46.387 79.7903 79.7903 57.4184 46.387 79.7903 0 0 Exp 2,1(1) 1.5558284521102905 1.5558284521102905 1.5558284521102905 1.5558284521102905 0.0 1.5558284521102905 57.4184 57.4184 46.387 46.387 79.7903 79.7903 UP 1.0 0.0 0.0 GO:0051726 5 regulation of cell cycle 252 268 12 12 9 12 9 9 87 259 2192 0.43517 0.69586 0.86537 3.36 257644;360243;308761;291234;299626;64515;362485;114494;25612 zwint;top2a;prc1;mki67;gadd45b;cdc20;ccne2;ccna2;asns ZWINT_10214;TOP2A_10059;PRC1_9556;MKI67_9232;GADD45B_8679;CDC20_8255;CCNE2_8227;CCNA2_8221;ASNS_8091 61.90584444444445 54.9577 28.1893 21.43795361654832 62.19073280843368 19.763447800748544 38.20744444444444 37.3288 18.8326 11.516801504878787 38.66523679149575 10.55250782770199 162.4191 108.188 35.9474 125.25512396584821 159.95672448502495 122.80057804690631 59.0663;54.9577;80.3005;49.7822;52.5718;101.569;77.8893;52.8265;28.1893 40.5797;18.8326;50.2731;35.6665;37.1918;51.5499;49.2672;37.3288;23.1774 108.188;218.525;198.961;82.1147;89.36;453.17;185.461;90.0448;35.9474 3 6 3 257644;299626;25612 ZWINT_10214;GADD45B_8679;ASNS_8091 46.60913333333334 52.5718 16.279199230408523 33.649633333333334 37.1918 9.226061990000565 77.8318 89.36 37.47466635635331 59.0663;52.5718;28.1893 40.5797;37.1918;23.1774 108.188;89.36;35.9474 6 360243;308761;291234;64515;362485;114494 TOP2A_10059;PRC1_9556;MKI67_9232;CDC20_8255;CCNE2_8227;CCNA2_8221 69.5542 66.4235 20.463186546967698 40.48635 43.298 12.628316641381767 204.71275 192.211 134.53959748323544 54.9577;80.3005;49.7822;101.569;77.8893;52.8265 18.8326;50.2731;35.6665;51.5499;49.2672;37.3288 218.525;198.961;82.1147;453.17;185.461;90.0448 0 Exp 2,3(0.34);Linear,6(0.67) 1.9068450626506104 17.716718792915344 1.5293418169021606 3.2609751224517822 0.5726468899388991 1.7985904216766357 47.89971474829954 75.91197414058936 30.683134127923655 45.731754760965245 80.58575234231252 244.25244765768753 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0002224 6 toll-like receptor signaling pathway 21 23 2 2 2 2 2 2 94 21 2430 0.94677 0.21415 0.21415 8.7 315994;63868 mapkapk3;hspd1 MAPKAPK3_9194;HSPD1_8849 69.31925 69.31925 34.4455 49.31893022080874 73.80712864963503 48.90884141520122 42.9287 42.9287 26.6907 22.963999825814327 45.01835693430657 22.773053282197566 241.73535 241.73535 48.4857 273.2962759538538 266.6045131466201 271.02380688607155 0.5 69.31925 104.193;34.4455 59.1667;26.6907 434.985;48.4857 1 1 1 63868 HSPD1_8849 34.4455 34.4455 26.6907 26.6907 48.4857 48.4857 34.4455 26.6907 48.4857 1 315994 MAPKAPK3_9194 104.193 104.193 59.1667 59.1667 434.985 434.985 104.193 59.1667 434.985 0 Exp 2,1(0.5);Linear,1(0.5) 1.5845445868246466 3.1721529960632324 1.5163835287094116 1.6557694673538208 0.09856074241751378 1.5860764980316162 0.966700000000003 137.6718 11.102220000000003 74.75518 -137.03396399999994 620.5046639999999 CONFLICT 0.5 0.5 0.0 GO:0050793 4 regulation of developmental process 584 616 22 21 15 22 14 14 82 602 1849 0.013771 0.99337 0.027998 2.27 29142;360268;25664;338475;259241;24484;24471;102551184;29455;58868;64515;25599;155423;502970 vnn1;sult1e1;pparg;nrep;nr1d2;igfbp3;hspb1;loc102551184;gdf15;fzd1;cdc20;cd74;anxa7;angptl3 VNN1_10157;SULT1E1_32446;PPARG_32510;NREP_9364;NR1D2_9358;IGFBP3_8881;HSPB1_8847;HIST1H4A_32934;GDF15_33113;FZD1_8671;CDC20_8255;CD74_8252;ANXA7_8051;ANGPTL3_8045 25664(0.0441) 58.96128571428572 58.8016 20.7328 26.654207001777884 63.083759328225966 23.33618373128677 37.471214285714275 41.38125 13.6792 13.253063447361189 40.787115335750705 11.838579894710042 121.21354285714285 103.975 26.3528 102.42742712398649 126.77507469396662 95.90986387058746 20.7328;59.2729;60.1903;69.4104;99.0234;50.946;41.6322;58.3303;21.3654;25.231;101.569;94.9138;64.7676;58.0729 16.8296;45.3114;43.9036;43.1468;42.5557;36.3081;30.9494;40.2068;17.8875;13.6792;51.5499;58.8146;43.3787;40.0757 26.7838;91.5578;101.057;157.944;102.838;85.0816;63.3196;105.902;26.3528;131.659;453.17;118.773;127.439;105.112 10 4 10 29142;360268;25664;259241;24471;29455;58868;25599;155423;502970 VNN1_10157;SULT1E1_32446;PPARG_32510;NR1D2_9358;HSPB1_8847;GDF15_33113;FZD1_8671;CD74_8252;ANXA7_8051;ANGPTL3_8045 54.520230000000005 58.6729 27.986770185970595 35.33854 41.3157 14.902002307087606 89.4892 101.94749999999999 38.35419127738483 20.7328;59.2729;60.1903;99.0234;41.6322;21.3654;25.231;94.9138;64.7676;58.0729 16.8296;45.3114;43.9036;42.5557;30.9494;17.8875;13.6792;58.8146;43.3787;40.0757 26.7838;91.5578;101.057;102.838;63.3196;26.3528;131.659;118.773;127.439;105.112 4 338475;24484;102551184;64515 NREP_9364;IGFBP3_8881;HIST1H4A_32934;CDC20_8255 70.063925 63.87035 22.33211333205693 42.8029 41.6768 6.469168892008717 200.5244 131.923 171.19514042666825 69.4104;50.946;58.3303;101.569 43.1468;36.3081;40.2068;51.5499 157.944;85.0816;105.902;453.17 0 Exp 2,5(0.36);Linear,6(0.43);Poly 2,2(0.15);Power,1(0.08) 2.092670158380906 32.085744857788086 1.5124053955078125 5.015069484710693 1.1629049323757261 1.6978691816329956 44.998958241933146 72.92361318663828 30.528835101385923 44.41359347004264 67.55877535420296 174.86831036008275 UP 0.7142857142857143 0.2857142857142857 0.0 GO:0033993 5 response to lipid 414 443 23 22 17 22 16 16 80 427 2024 0.4895 0.61917 1.0 3.61 286954;78968;24950;84386;25664;24614;315994;24484;63868;24471;58868;25315;25413;114494;25649;140668 ugt2b1;srebf1;srd5a1;slpi;pparg;orm1;mapkapk3;igfbp3;hspd1;hspb1;fzd1;ephx1;cpt2;ccna2;apoa2;abcc3 UGT2B10_33303,UGT2B1_33224;SREBF1_32750;SRD5A1_32503;SLPI_9890;PPARG_32510;ORM1_9400;MAPKAPK3_9194;IGFBP3_8881;HSPD1_8849;HSPB1_8847;FZD1_8671;EPHX1_8567;CPT2_8374;CCNA2_8221;APOA2_33095;ABCC3_7941 25664(0.0441) 39.623076875 34.61150000000001 3.54778 22.86145046067191 41.61607073593074 24.120016624946253 27.9056115625 26.67345 1.51564 14.00419326745978 29.183355595580405 14.548456165409334 84.55076875 54.92395 8.55785 98.70694093999988 90.11545695063248 106.09637860374771 12.54415;41.2009;29.2087;53.7429;60.1903;24.2519;104.193;50.946;34.4455;41.6322;25.231;34.0134;31.2175;52.8265;3.54778;34.7775 7.348245;31.4864;22.9308;37.8192;43.9036;19.7133;59.1667;36.3081;26.6907;30.9494;13.6792;26.1579;24.8356;37.3288;1.51564;26.6562 25.495849999999997;60.0774;39.9852;92.543;101.057;31.358;434.985;85.0816;48.4857;63.3196;131.659;48.3681;42.0237;90.0448;8.55785;49.7705 12 5 11 286954;78968;25664;24614;63868;24471;58868;25315;25413;25649;140668 UGT2B10_33303,UGT2B1_33224;SREBF1_32750;PPARG_32510;ORM1_9400;HSPD1_8849;HSPB1_8847;FZD1_8671;EPHX1_8567;CPT2_8374;APOA2_33095;ABCC3_7941 31.18655727272727 34.0134 15.090138074367703 22.994198636363635 26.1579 11.902679368468283 55.47024545454545 48.4857 34.58160694378194 12.54415;41.2009;60.1903;24.2519;34.4455;41.6322;25.231;34.0134;31.2175;3.54778;34.7775 7.348245;31.4864;43.9036;19.7133;26.6907;30.9494;13.6792;26.1579;24.8356;1.51564;26.6562 25.495849999999997;60.0774;101.057;31.358;48.4857;63.3196;131.659;48.3681;42.0237;8.55785;49.7705 5 24950;84386;315994;24484;114494 SRD5A1_32503;SLPI_9890;MAPKAPK3_9194;IGFBP3_8881;CCNA2_8221 58.18342 52.8265 27.646025522975258 38.710719999999995 37.3288 12.999327738656334 148.52792 90.0448 161.56980137158058 29.2087;53.7429;104.193;50.946;52.8265 22.9308;37.8192;59.1667;36.3081;37.3288 39.9852;92.543;434.985;85.0816;90.0448 0 Exp 2,5(0.3);Exp 4,1(0.06);Hill,1(0.06);Linear,8(0.48);Poly 2,2(0.12) 1.8544702903030665 32.24835956096649 1.5124053955078125 3.5849626064300537 0.48311157930548504 1.7380040884017944 28.42096614927076 50.825187600729244 21.04355686144471 34.76766626355529 36.184367689400055 132.91716981059994 UP 0.6875 0.3125 0.0 GO:0070887 4 cellular response to chemical stimulus 594 635 20 20 14 20 14 14 82 621 1830 0.0089417 0.99585 0.015887 2.2 286954;78968;24950;25664;24614;24484;63868;24471;58868;25315;114494;25612;65155;170465 ugt2b1;srebf1;srd5a1;pparg;orm1;igfbp3;hspd1;hspb1;fzd1;ephx1;ccna2;asns;alas1;acaa2 UGT2B10_33303,UGT2B1_33224;SREBF1_32750;SRD5A1_32503;PPARG_32510;ORM1_9400;IGFBP3_8881;HSPD1_8849;HSPB1_8847;FZD1_8671;EPHX1_8567;CCNA2_8221;ASNS_8091;ALAS1_8018;ACAA2_7955 25664(0.0441) 38.59021071428572 34.22945 12.54415 17.208137051364094 40.35400301470589 18.15959484774246 27.48598178571429 26.424300000000002 7.348245 10.619413037543659 28.586644853955374 11.005174629511297 64.02241785714286 54.281549999999996 25.495849999999997 32.156925873618405 65.32198945993913 31.602397564793666 12.54415;41.2009;29.2087;60.1903;24.2519;50.946;34.4455;41.6322;25.231;34.0134;52.8265;28.1893;27.1843;78.3988 7.348245;31.4864;22.9308;43.9036;19.7133;36.3081;26.6907;30.9494;13.6792;26.1579;37.3288;23.1774;21.5215;43.6084 25.495849999999997;60.0774;39.9852;101.057;31.358;85.0816;48.4857;63.3196;131.659;48.3681;90.0448;35.9474;36.6615;98.7727 11 4 10 286954;78968;25664;24614;63868;24471;58868;25315;25612;65155 UGT2B10_33303,UGT2B1_33224;SREBF1_32750;PPARG_32510;ORM1_9400;HSPD1_8849;HSPB1_8847;FZD1_8671;EPHX1_8567;ASNS_8091;ALAS1_8018 32.888295 31.101349999999996 12.894302515677436 24.462764500000002 24.667650000000002 10.106344621492983 58.24295500000001 48.4269 33.6696980086319 12.54415;41.2009;60.1903;24.2519;34.4455;41.6322;25.231;34.0134;28.1893;27.1843 7.348245;31.4864;43.9036;19.7133;26.6907;30.9494;13.6792;26.1579;23.1774;21.5215 25.495849999999997;60.0774;101.057;31.358;48.4857;63.3196;131.659;48.3681;35.9474;36.6615 4 24950;24484;114494;170465 SRD5A1_32503;IGFBP3_8881;CCNA2_8221;ACAA2_7955 52.845 51.886250000000004 20.12691328693994 35.044025000000005 36.81845 8.696681770412955 78.471075 87.5632 26.27399667166188 29.2087;50.946;52.8265;78.3988 22.9308;36.3081;37.3288;43.6084 39.9852;85.0816;90.0448;98.7727 0 Exp 2,5(0.34);Exp 4,1(0.07);Linear,6(0.4);Poly 2,3(0.2) 1.9496853369811937 30.245677709579468 1.5124053955078125 3.5849626064300537 0.609130758223044 1.8392632007598877 29.57603727876603 47.60438414980539 21.923193052796265 33.04877051863231 47.177589964807574 80.86724574947814 UP 0.7142857142857143 0.2857142857142857 0.0 GO:0034097 5 response to cytokine 230 247 4 4 3 4 3 3 93 244 2207 0.012235 0.99685 0.021527 1.21 315994;63868;24471 mapkapk3;hspd1;hspb1 MAPKAPK3_9194;HSPD1_8849;HSPB1_8847 60.09023333333332 41.6322 34.4455 38.36277733641471 63.70922110621156 39.56513567158737 38.9356 30.9494 26.6907 17.649566193819034 40.60289954815178 18.18855304608165 182.26343333333332 63.3196 48.4857 218.9889354308645 202.80476769013012 226.16212384213918 104.193;34.4455;41.6322 59.1667;26.6907;30.9494 434.985;48.4857;63.3196 2 1 2 63868;24471 HSPD1_8849;HSPB1_8847 38.03885 38.03885 5.081764304353405 28.820050000000002 28.820050000000002 3.0113556490391393 55.90265 55.90265 10.48915128144312 34.4455;41.6322 26.6907;30.9494 48.4857;63.3196 1 315994 MAPKAPK3_9194 104.193 104.193 59.1667 59.1667 434.985 434.985 104.193 59.1667 434.985 0 Exp 2,1(0.34);Linear,2(0.67) 1.6675545387528157 5.019001245498657 1.5163835287094116 1.8468482494354248 0.16590482838969958 1.6557694673538208 16.67866408213355 103.50180258453311 18.96323568556018 58.90796431443982 -65.54587547496266 430.07274214162936 UP 0.6666666666666666 0.3333333333333333 0.0 GO:1901568 4 fatty acid derivative metabolic process 46 57 12 12 12 12 12 12 84 45 2406 1.0 7.1642E-7 7.1642E-7 21.05 364975;25315;50549;65210;25086;24303;499353;171521;29277;24894;25599;50681 gcdh;ephx1;cyp4a1;cyp2j4;cyp2e1;cyp2d3;cyp2c24;cyp2c13;cyp2c11;cyp2a1;cd74;acox1 GCDH_8693;EPHX1_8567;CYP4A1_33111;CYP2J4_32580;CYP2E1_8421;CYP2D3_8420;CYP2C24_32875;CYP2C13_8419;CYP2C11_32593;CYP2A1_32717;CD74_8252;ACOX1_7973 38.0190175 23.5047 7.89174 33.225803521607105 44.33049794191801 36.32883621123567 25.078094166666663 18.98115 4.16797 19.7473595760135 28.379931983912062 21.39236103007818 51.47922500000001 34.09825 15.8079 35.41773126831774 59.055123961154166 37.6983953632136 1.5 11.088885 4.5 19.76175 15.9021;34.0134;23.208;16.3155;7.89174;12.8059;58.9435;104.635;54.426;9.37187;94.9138;23.8014 10.4227;26.1579;18.863;8.2378;4.16797;8.8664;48.1505;49.2461;43.9518;4.95906;58.8146;19.0993 31.2818;48.3681;29.9853;36.8422;15.8079;22.6004;80.4167;108.327;74.8861;19.1079;118.773;31.3543 12 0 12 364975;25315;50549;65210;25086;24303;499353;171521;29277;24894;25599;50681 GCDH_8693;EPHX1_8567;CYP4A1_33111;CYP2J4_32580;CYP2E1_8421;CYP2D3_8420;CYP2C24_32875;CYP2C13_8419;CYP2C11_32593;CYP2A1_32717;CD74_8252;ACOX1_7973 38.0190175 23.5047 33.225803521607105 25.078094166666663 18.98115 19.7473595760135 51.47922500000001 34.09825 35.41773126831774 15.9021;34.0134;23.208;16.3155;7.89174;12.8059;58.9435;104.635;54.426;9.37187;94.9138;23.8014 10.4227;26.1579;18.863;8.2378;4.16797;8.8664;48.1505;49.2461;43.9518;4.95906;58.8146;19.0993 31.2818;48.3681;29.9853;36.8422;15.8079;22.6004;80.4167;108.327;74.8861;19.1079;118.773;31.3543 0 0 Exp 2,3(0.25);Exp 4,3(0.25);Linear,2(0.17);Poly 2,3(0.25);Power,1(0.09) 1.940776641990776 23.911189317703247 1.5310101509094238 2.9415390491485596 0.49894114711169485 1.8444237112998962 19.219749424903352 56.81828557509664 13.904973667010857 36.25121466632248 31.439757051787904 71.51869294821209 UP 1.0 0.0 0.0 GO:0043567 6 regulation of insulin-like growth factor receptor signaling pathway 8 8 2 2 2 2 2 2 94 6 2445 0.99747 0.033945 0.033945 25.0 24484;25685 igfbp3;igfbp1 IGFBP3_8881;IGFBP1_32306 74.89155 74.89155 50.946 33.86412156848311 62.619081007509386 29.078372362663515 46.81805 46.81805 36.3081 14.863313829863097 41.431536201501885 12.762798917250796 221.2453 221.2453 85.0816 192.56455124290144 151.45927352941177 165.35092202425943 0.0 50.946 0.0 50.946 50.946;98.8371 36.3081;57.328 85.0816;357.409 1 1 1 25685 IGFBP1_32306 98.8371 98.8371 57.328 57.328 357.409 357.409 98.8371 57.328 357.409 1 24484 IGFBP3_8881 50.946 50.946 36.3081 36.3081 85.0816 85.0816 50.946 36.3081 85.0816 0 Linear,2(1) 1.8792316810418066 3.7699393033981323 1.7380040884017944 2.031935214996338 0.20784069281680323 1.8849696516990662 27.958271999999994 121.824828 26.218548000000002 67.417552 -45.63555200000002 488.126152 CONFLICT 0.5 0.5 0.0 GO:0014074 6 response to purine-containing compound 89 91 6 6 5 6 5 5 91 86 2365 0.8744 0.25717 0.39073 5.49 78968;24950;25664;63868;65155 srebf1;srd5a1;pparg;hspd1;alas1 SREBF1_32750;SRD5A1_32503;PPARG_32510;HSPD1_8849;ALAS1_8018 25664(0.0441) 38.44594 34.4455 27.1843 13.309410720539054 41.686984564015724 13.792513556524792 29.306600000000003 26.6907 21.5215 9.026703128772972 31.53415914624405 9.316387274622738 57.25336 48.4857 36.6615 26.104693012425948 63.35209000223664 27.378514942577837 3.5 50.6956 41.2009;29.2087;60.1903;34.4455;27.1843 31.4864;22.9308;43.9036;26.6907;21.5215 60.0774;39.9852;101.057;48.4857;36.6615 4 1 4 78968;25664;63868;65155 SREBF1_32750;PPARG_32510;HSPD1_8849;ALAS1_8018 40.755250000000004 37.8232 14.164549662096558 30.90055 29.088549999999998 9.576219599438321 61.57040000000001 54.281549999999996 28.006447483035018 41.2009;60.1903;34.4455;27.1843 31.4864;43.9036;26.6907;21.5215 60.0774;101.057;48.4857;36.6615 1 24950 SRD5A1_32503 29.2087 29.2087 22.9308 22.9308 39.9852 39.9852 29.2087 22.9308 39.9852 0 Exp 2,3(0.6);Linear,2(0.4) 1.768933229495147 8.882850766181946 1.5239794254302979 1.9512832164764404 0.1812056544160871 1.8392632007598877 26.779727132256802 50.1121528677432 21.394345851010602 37.21885414898941 34.371587701841115 80.13513229815888 UP 0.8 0.2 0.0 GO:0051591 5 response to cAMP 57 59 4 4 3 4 3 3 93 56 2395 0.81959 0.38538 0.48629 5.08 78968;24950;65155 srebf1;srd5a1;alas1 SREBF1_32750;SRD5A1_32503;ALAS1_8018 32.531299999999995 29.2087 27.1843 7.5760162328231795 34.84823050425519 8.047430343264018 25.3129 22.9308 21.5215 5.392643907212862 26.963267892085913 5.728361726077903 45.5747 39.9852 36.6615 12.669174238678703 49.451513987147564 13.45782809682363 1.5 35.2048 41.2009;29.2087;27.1843 31.4864;22.9308;21.5215 60.0774;39.9852;36.6615 2 1 2 78968;65155 SREBF1_32750;ALAS1_8018 34.1926 34.1926 9.911232909179352 26.50395 26.50395 7.046248363845835 48.36945 48.36945 16.55754167758605 41.2009;27.1843 31.4864;21.5215 60.0774;36.6615 1 24950 SRD5A1_32503 29.2087 29.2087 22.9308 22.9308 39.9852 39.9852 29.2087 22.9308 39.9852 0 Exp 2,1(0.34);Linear,2(0.67) 1.90046295808243 5.703101873397827 1.8392632007598877 1.9512832164764404 0.05689182431305236 1.912555456161499 23.95823057764537 41.10436942235464 19.210548953512642 31.415251046487356 31.238179732061617 59.91122026793838 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0001101 4 response to acid chemical 195 202 12 12 9 12 9 9 87 193 2258 0.77355 0.35005 0.56276 4.46 78968;83500;25664;24614;25626;24471;25086;25413;25612 srebf1;slc22a8;pparg;orm1;krt8;hspb1;cyp2e1;cpt2;asns SREBF1_32750;SLC22A8_9848;PPARG_32510;ORM1_9400;KRT8_8978;HSPB1_8847;CYP2E1_8421;CPT2_8374;ASNS_8091 25664(0.0441) 39.55758222222222 41.2009 7.89174 19.03911014322478 43.2764862845435 18.710417921795166 28.968774444444445 30.9494 4.16797 12.84283450539162 31.395668544134065 12.37656780884254 64.70124444444444 60.0774 15.8079 40.32263382655301 72.3358814502024 40.80879081420802 41.2009;52.4905;60.1903;24.2519;68.9539;41.6322;7.89174;31.2175;28.1893 31.4864;37.1479;43.9036;19.7133;45.3374;30.9494;4.16797;24.8356;23.1774 60.0774;89.1422;101.057;31.358;143.578;63.3196;15.8079;42.0237;35.9474 9 0 9 78968;83500;25664;24614;25626;24471;25086;25413;25612 SREBF1_32750;SLC22A8_9848;PPARG_32510;ORM1_9400;KRT8_8978;HSPB1_8847;CYP2E1_8421;CPT2_8374;ASNS_8091 39.55758222222222 41.2009 19.03911014322478 28.968774444444445 30.9494 12.84283450539162 64.70124444444444 60.0774 40.32263382655301 41.2009;52.4905;60.1903;24.2519;68.9539;41.6322;7.89174;31.2175;28.1893 31.4864;37.1479;43.9036;19.7133;45.3374;30.9494;4.16797;24.8356;23.1774 60.0774;89.1422;101.057;31.358;143.578;63.3196;15.8079;42.0237;35.9474 0 0 Exp 2,5(0.56);Exp 4,1(0.12);Linear,3(0.34) 1.983605077329634 18.78075349330902 1.5239794254302979 3.5849626064300537 0.7758233850811247 1.8468482494354248 27.118696928648703 51.99646751579574 20.578122567588586 37.35942632130031 38.35712367776314 91.04536521112574 UP 1.0 0.0 0.0 GO:0007017 3 microtubule-based process 97 110 7 7 6 6 6 6 90 104 2347 0.88224 0.23212 0.3053 5.45 308761;304951;293502;303575;24471;64515 prc1;nuf2;kif22;kif18b;hspb1;cdc20 PRC1_9556;NUF2_33136;KIF22_8963;KIF18B_32882;HSPB1_8847;CDC20_8255 60.56691666666676 69.9499 5.73955E-13 35.51063077611624 64.95875174126485 29.047781228061968 37.38140000000009 45.757999999999996 5.73955E-13 19.761159084932032 40.688412246607044 15.61754066086013 168.79943333333344 148.673 5.73957E-13 156.69485375035975 171.62284328616812 140.33699745016867 4.5 90.93475000000001 80.3005;5.73955E-13;73.9175;65.9823;41.6322;101.569 50.2731;5.73955E-13;47.5608;43.9552;30.9494;51.5499 198.961;5.73957E-13;165.416;131.93;63.3196;453.17 1 5 1 24471 HSPB1_8847 41.6322 41.6322 30.9494 30.9494 63.3196 63.3196 41.6322 30.9494 63.3196 5 308761;304951;293502;303575;64515 PRC1_9556;NUF2_33136;KIF22_8963;KIF18B_32882;CDC20_8255 64.35386000000011 73.9175 38.32360987789357 38.66780000000012 47.5608 21.810962227168893 189.8954000000001 165.416 165.38983619860065 80.3005;5.73955E-13;73.9175;65.9823;101.569 50.2731;5.73955E-13;47.5608;43.9552;51.5499 198.961;5.73957E-13;165.416;131.93;453.17 0 Exp 2,1(0.17);Hill,1(0.17);Linear,4(0.67) 1.7879925430989665 10.765777587890625 1.5293418169021606 2.020775556564331 0.16254356892723568 1.8227193355560303 32.1524942236867 88.98133910964683 21.569179548544547 53.19362045145565 43.41743724391739 294.1814294227495 DOWN 0.16666666666666666 0.8333333333333334 0.0 GO:0034645 5 cellular macromolecule biosynthetic process 143 162 6 6 4 6 4 4 92 158 2293 0.25702 0.8714 0.52086 2.47 78968;313245;362094;65155 srebf1;polr1e;mrps2;alas1 SREBF1_32750;POLR1E_9523;MRPS2_9250;ALAS1_8018 51.42075 52.25835 27.1843 21.153038069349137 49.015773365016614 17.578793664688966 36.48495 38.41465 21.5215 12.256339075623966 35.8466141355091 10.870180720896599 93.42647500000001 85.66120000000001 36.6615 57.38340630736234 81.96259960045421 42.84115110954186 41.2009;73.982;63.3158;27.1843 31.4864;47.589;45.3429;21.5215 60.0774;165.722;111.245;36.6615 4 0 4 78968;313245;362094;65155 SREBF1_32750;POLR1E_9523;MRPS2_9250;ALAS1_8018 51.42075 52.25835 21.153038069349137 36.48495 38.41465 12.256339075623966 93.42647500000001 85.66120000000001 57.38340630736234 41.2009;73.982;63.3158;27.1843 31.4864;47.589;45.3429;21.5215 60.0774;165.722;111.245;36.6615 0 0 Exp 2,2(0.5);Linear,2(0.5) 1.6901583309213062 6.798014521598816 1.5184675455093384 1.912555456161499 0.2059163580589998 1.6834957599639893 30.690772692037854 72.15072730796214 24.473737705888524 48.49616229411147 37.1907368187849 149.66221318121512 UP 1.0 0.0 0.0 GO:0019835 3 cytolysis 7 7 1 1 1 1 1 1 95 6 2445 0.97391 0.23606 0.23606 14.29 25211 lyz2 LYZ2_32611 77.8257 77.8257 77.8257 77.82570000000001 49.2403 49.2403 49.2403 49.2403 185.119 185.119 185.119 185.119 0.0 77.8257 0.0 77.8257 77.8257 49.2403 185.119 0 1 0 1 25211 LYZ2_32611 77.8257 77.8257 49.2403 49.2403 185.119 185.119 77.8257 49.2403 185.119 0 Linear,1(1) 1.7436412572860718 1.7436412572860718 1.7436412572860718 1.7436412572860718 0.0 1.7436412572860718 77.8257 77.8257 49.2403 49.2403 185.119 185.119 DOWN 0.0 1.0 0.0 GO:2000844 7 negative regulation of testosterone secretion 1 1 1 1 1 1 1 1 95 0 2451 1.0 0.037691 0.037691 100.0 24484 igfbp3 IGFBP3_8881 50.946 50.946 50.946 50.946 36.3081 36.3081 36.3081 36.3081 85.0816 85.0816 85.0816 85.0816 0.0 50.946 0.0 50.946 50.946 36.3081 85.0816 0 1 0 1 24484 IGFBP3_8881 50.946 50.946 36.3081 36.3081 85.0816 85.0816 50.946 36.3081 85.0816 0 Linear,1(1) 1.7380040884017944 1.7380040884017944 1.7380040884017944 1.7380040884017944 0.0 1.7380040884017944 50.946 50.946 36.3081 36.3081 85.0816 85.0816 DOWN 0.0 1.0 0.0 GO:1901700 4 response to oxygen-containing compound 599 638 32 31 22 30 20 20 76 618 1833 0.19862 0.86352 0.4005 3.13 286954;78968;24950;84386;83500;25664;24614;315994;25626;24484;63868;24471;58868;25086;25413;114494;25612;25649;65155;140668 ugt2b1;srebf1;srd5a1;slpi;slc22a8;pparg;orm1;mapkapk3;krt8;igfbp3;hspd1;hspb1;fzd1;cyp2e1;cpt2;ccna2;asns;apoa2;alas1;abcc3 UGT2B10_33303,UGT2B1_33224;SREBF1_32750;SRD5A1_32503;SLPI_9890;SLC22A8_9848;PPARG_32510;ORM1_9400;MAPKAPK3_9194;KRT8_8978;IGFBP3_8881;HSPD1_8849;HSPB1_8847;FZD1_8671;CYP2E1_8421;CPT2_8374;CCNA2_8221;ASNS_8091;APOA2_33095;ALAS1_8018;ABCC3_7941 25664(0.0441) 39.2332785 34.61150000000001 3.54778 23.08266763076763 42.42028329446651 24.024100004970208 27.584202750000003 26.67345 1.51564 14.423147520471481 29.593963972039347 14.791246520145712 81.27906 54.92395 8.55785 91.04920085617762 89.14795934772411 96.86758527713812 12.54415;41.2009;29.2087;53.7429;52.4905;60.1903;24.2519;104.193;68.9539;50.946;34.4455;41.6322;25.231;7.89174;31.2175;52.8265;28.1893;3.54778;27.1843;34.7775 7.348245;31.4864;22.9308;37.8192;37.1479;43.9036;19.7133;59.1667;45.3374;36.3081;26.6907;30.9494;13.6792;4.16797;24.8356;37.3288;23.1774;1.51564;21.5215;26.6562 25.495849999999997;60.0774;39.9852;92.543;89.1422;101.057;31.358;434.985;143.578;85.0816;48.4857;63.3196;131.659;15.8079;42.0237;90.0448;35.9474;8.55785;36.6615;49.7705 16 5 15 286954;78968;83500;25664;24614;25626;63868;24471;58868;25086;25413;25612;25649;65155;140668 UGT2B10_33303,UGT2B1_33224;SREBF1_32750;SLC22A8_9848;PPARG_32510;ORM1_9400;KRT8_8978;HSPD1_8849;HSPB1_8847;FZD1_8671;CYP2E1_8421;CPT2_8374;ASNS_8091;APOA2_33095;ALAS1_8018;ABCC3_7941 32.916564666666666 31.2175 18.26807915873199 23.875363666666665 24.8356 13.23215017663074 58.86277333333332 48.4857 40.47978791771478 12.54415;41.2009;52.4905;60.1903;24.2519;68.9539;34.4455;41.6322;25.231;7.89174;31.2175;28.1893;3.54778;27.1843;34.7775 7.348245;31.4864;37.1479;43.9036;19.7133;45.3374;26.6907;30.9494;13.6792;4.16797;24.8356;23.1774;1.51564;21.5215;26.6562 25.495849999999997;60.0774;89.1422;101.057;31.358;143.578;48.4857;63.3196;131.659;15.8079;42.0237;35.9474;8.55785;36.6615;49.7705 5 24950;84386;315994;24484;114494 SRD5A1_32503;SLPI_9890;MAPKAPK3_9194;IGFBP3_8881;CCNA2_8221 58.18342 52.8265 27.646025522975258 38.710719999999995 37.3288 12.999327738656334 148.52792 90.0448 161.56980137158058 29.2087;53.7429;104.193;50.946;52.8265 22.9308;37.8192;59.1667;36.3081;37.3288 39.9852;92.543;434.985;85.0816;90.0448 0 Exp 2,6(0.29);Exp 4,2(0.1);Hill,1(0.05);Linear,10(0.48);Poly 2,2(0.1) 1.8562659526068237 40.122881174087524 1.5124053955078125 3.5849626064300537 0.5417967556704162 1.729828953742981 29.11685337081164 49.349703629188355 21.262979642164773 33.90542585783523 41.374988327356725 121.18313167264327 UP 0.75 0.25 0.0 GO:0051315 5 attachment of mitotic spindle microtubules to kinetochore 3 3 1 1 1 1 1 1 95 2 2449 0.99588 0.10891 0.10891 33.33 304951 nuf2 NUF2_33136 5.73955E-13 5.73955E-13 5.73955E-13 5.73955E-13 5.73955E-13 5.73955E-13 5.73955E-13 5.73955E-13 5.73957E-13 5.73957E-13 5.73957E-13 5.73957E-13 0.0 5.73955E-13 0.0 5.73955E-13 5.73955E-13 5.73955E-13 5.73957E-13 0 1 0 1 304951 NUF2_33136 5.73955E-13 5.73955E-13 5.73955E-13 5.73955E-13 5.73957E-13 5.73957E-13 5.73955E-13 5.73955E-13 5.73957E-13 0 Hill,1(1) 1.84699547290802 1.84699547290802 1.84699547290802 1.84699547290802 0.0 1.84699547290802 5.73955E-13 5.73955E-13 5.73955E-13 5.73955E-13 5.73957E-13 5.73957E-13 DOWN 0.0 1.0 0.0 GO:0048608 4 reproductive structure development 101 108 4 4 3 4 3 3 93 105 2346 0.41145 0.78393 0.79678 2.78 24950;25664;50549 srd5a1;pparg;cyp4a1 SRD5A1_32503;PPARG_32510;CYP4A1_33111 25664(0.0441) 37.535666666666664 29.2087 23.208 19.847579417232048 47.80040781057365 19.435223375706244 28.5658 22.9308 18.863 13.437739052385258 35.5157921821742 13.157592797188737 57.009166666666665 39.9852 29.9853 38.47282438323619 76.81062626731453 37.97972769579779 29.2087;60.1903;23.208 22.9308;43.9036;18.863 39.9852;101.057;29.9853 2 1 2 25664;50549 PPARG_32510;CYP4A1_33111 41.69915 41.69915 26.15043511387525 31.3833 31.3833 17.706378064979855 65.52115 65.52115 50.25528102045594 60.1903;23.208 43.9036;18.863 101.057;29.9853 1 24950 SRD5A1_32503 29.2087 29.2087 22.9308 22.9308 39.9852 39.9852 29.2087 22.9308 39.9852 0 Exp 2,2(0.67);Linear,1(0.34) 1.824548799000006 5.517786026000977 1.5239794254302979 2.0425233840942383 0.2768276043244844 1.9512832164764404 15.07601624083592 59.99531709249741 13.359566771978626 43.77203322802137 13.47306745893929 100.54526587439403 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0006281 6 DNA repair 69 74 2 2 2 2 2 2 94 72 2379 0.46571 0.77739 1.0 2.7 316273;293502 mcm3;kif22 MCM3_9207;KIF22_8963 63.961 63.961 54.0045 14.080617333767751 61.990585154201526 13.802127197316839 40.4099 40.4099 33.259 10.11289976317377 38.994720014983145 9.912884183728526 138.5845 138.5845 111.753 37.9454711988138 133.27448283181423 37.194975733923194 54.0045;73.9175 33.259;47.5608 111.753;165.416 0 2 0 2 316273;293502 MCM3_9207;KIF22_8963 63.961 63.961 14.080617333767751 40.4099 40.4099 10.11289976317377 138.5845 138.5845 37.9454711988138 54.0045;73.9175 33.259;47.5608 111.753;165.416 0 Exp 2,1(0.5);Linear,1(0.5) 1.8306528764929137 3.6791932582855225 1.6584177017211914 2.020775556564331 0.2562256963757947 1.8395966291427612 44.446259999999995 83.47574 26.394136000000003 54.425664 85.99476 191.17424 DOWN 0.0 1.0 0.0 GO:0006766 4 vitamin metabolic process 19 23 2 2 2 2 2 2 94 21 2430 0.94677 0.21415 0.21415 8.7 29142;296371 vnn1;pltp VNN1_10157;PLTP_32412 53.8792 53.8792 20.7328 46.87608842384355 70.589075206169 40.48367334010733 36.7281 36.7281 16.8296 28.14072857088104 46.75939907893328 24.303223697237886 65.6734 65.6734 26.7838 54.99819975526473 85.27855660276319 47.49818570726954 0.5 53.8792 20.7328;87.0256 16.8296;56.6266 26.7838;104.563 2 0 2 29142;296371 VNN1_10157;PLTP_32412 53.8792 53.8792 46.87608842384355 36.7281 36.7281 28.14072857088104 65.6734 65.6734 54.99819975526473 20.7328;87.0256 16.8296;56.6266 26.7838;104.563 0 0 Linear,1(0.5);Poly 2,1(0.5) 2.636571632370004 6.116914391517639 1.5084086656570435 4.608505725860596 2.1920996536064123 3.0584571957588196 -11.087744 118.846144 -2.2729599999999976 75.72916 -10.550215999999992 141.897016 UP 1.0 0.0 0.0 GO:0010557 7 positive regulation of macromolecule biosynthetic process 371 401 14 14 12 14 12 12 84 389 2062 0.23175 0.8499 0.47445 2.99 360243;78968;25664;54133;65035;259241;24471;58868;306575;25599;114494;25649 top2a;srebf1;pparg;pdlim1;nr1i3;nr1d2;hspb1;fzd1;ckap2;cd74;ccna2;apoa2 TOP2A_10059;SREBF1_32750;PPARG_32510;PDLIM1_9452;NR1I3_32602;NR1D2_9358;HSPB1_8847;FZD1_8671;CKAP2_8324;CD74_8252;CCNA2_8221;APOA2_33095 25664(0.0441) 52.24553166666667 53.8921 3.54778 28.105021984621047 52.605902132959315 27.025793642185533 31.86450333333333 34.4076 1.51564 16.945436291305068 33.56853312969962 17.107387525710614 100.00537916666667 101.94749999999999 8.55785 52.20518552784796 97.52714092479317 48.75722080155693 54.9577;41.2009;60.1903;67.1147;22.095;99.0234;41.6322;25.231;64.2131;94.9138;52.8265;3.54778 18.8326;31.4864;43.9036;47.2419;12.9529;42.5557;30.9494;13.6792;43.1133;58.8146;37.3288;1.51564 218.525;60.0774;101.057;123.914;55.8619;102.838;63.3196;131.659;125.437;118.773;90.0448;8.55785 9 3 9 78968;25664;54133;65035;259241;24471;58868;25599;25649 SREBF1_32750;PPARG_32510;PDLIM1_9452;NR1I3_32602;NR1D2_9358;HSPB1_8847;FZD1_8671;CD74_8252;APOA2_33095 50.54989777777777 41.6322 32.61905544820458 31.45548222222222 31.4864 18.811219287657686 85.11752777777777 101.057 40.60708264445005 41.2009;60.1903;67.1147;22.095;99.0234;41.6322;25.231;94.9138;3.54778 31.4864;43.9036;47.2419;12.9529;42.5557;30.9494;13.6792;58.8146;1.51564 60.0774;101.057;123.914;55.8619;102.838;63.3196;131.659;118.773;8.55785 3 360243;306575;114494 TOP2A_10059;CKAP2_8324;CCNA2_8221 57.332433333333334 54.9577 6.0533613549278815 33.091566666666665 37.3288 12.68281151256825 144.66893333333334 125.437 66.36407833167979 54.9577;64.2131;52.8265 18.8326;43.1133;37.3288 218.525;125.437;90.0448 0 Exp 2,4(0.34);Hill,1(0.09);Linear,3(0.25);Poly 2,3(0.25);Power,1(0.09) 1.9111429392546817 23.373162746429443 1.5124053955078125 2.7270524501800537 0.4118449499224381 1.8264771699905396 36.34361849843337 68.14744483489996 22.276720173099108 41.45228649356755 70.46751480742122 129.5432435259121 UP 0.75 0.25 0.0 GO:0009056 3 catabolic process 364 413 35 34 32 35 31 31 65 382 2069 0.99998 5.4197E-5 6.0294E-5 7.51 286954;360268;64305;24950;364975;65030;25315;171142;291075;29740;64526;117543;114027;65210;25086;24303;499353;171521;29277;24894;311849;25413;64515;25649;155423;502970;26760;50681;681337;192272;170465 ugt2b1;sult1e1;sult1b1;srd5a1;gcdh;ephx2;ephx1;ehhadh;eci2;eci1;ech1;decr1;dao;cyp2j4;cyp2e1;cyp2d3;cyp2c24;cyp2c13;cyp2c11;cyp2a1;crat;cpt2;cdc20;apoa2;anxa7;angptl3;akr7a3;acox1;acot4;acot2;acaa2 UGT2B10_33303,UGT2B1_33224;SULT1E1_32446;SULT1B1_32942;SRD5A1_32503;GCDH_8693;EPHX2_33282;EPHX1_8567;EHHADH_8534;ECI2_8521;ECI1_8520;ECH1_8516;DECR1_8458;DAO_8437;CYP2J4_32580;CYP2E1_8421;CYP2D3_8420;CYP2C24_32875;CYP2C13_8419;CYP2C11_32593;CYP2A1_32717;CRAT_8375;CPT2_8374;CDC20_8255;APOA2_33095;ANXA7_8051;ANGPTL3_8045;AKR7A3_8015;ACOX1_7973;ACOT4_7971;ACOT2_7969;ACAA2_7955 29.606074193548384 15.9021 3.54778 28.421755883431125 32.18625186204215 29.454585742837413 19.065354677419354 10.4227 1.51564 17.232623152851538 20.678739031025284 17.90135641992297 56.45673225806452 31.3543 8.55785 80.61695096730439 57.833864146147874 73.65251989798898 19.5 26.50505 12.54415;59.2729;15.4629;29.2087;15.9021;6.44145;34.0134;7.29984;8.72912;11.7653;9.87438;21.6199;6.1336;16.3155;7.89174;12.8059;58.9435;104.635;54.426;9.37187;8.98517;31.2175;101.569;3.54778;64.7676;58.0729;18.819;23.8014;12.3157;13.6362;78.3988 7.348245;45.3114;7.69418;22.9308;10.4227;2.66377;26.1579;5.26587;5.10151;8.40998;6.59127;17.4928;2.43617;8.2378;4.16797;8.8664;48.1505;49.2461;43.9518;4.95906;1.97988;24.8356;51.5499;1.51564;43.3787;40.0757;11.5469;19.0993;6.70485;11.3249;43.6084 25.495849999999997;91.5578;35.0879;39.9852;31.2818;17.3473;48.3681;11.8779;17.7951;18.8402;19.44;28.0829;16.2027;36.8422;15.8079;22.6004;80.4167;108.327;74.8861;19.1079;31.3726;42.0237;453.17;8.55785;127.439;105.112;51.6405;31.3543;24.3993;16.9658;98.7727 29 3 28 286954;360268;64305;364975;65030;25315;171142;291075;29740;64526;117543;114027;65210;25086;24303;499353;171521;29277;24894;311849;25413;25649;155423;502970;26760;50681;681337;192272 UGT2B10_33303,UGT2B1_33224;SULT1E1_32446;SULT1B1_32942;GCDH_8693;EPHX2_33282;EPHX1_8567;EHHADH_8534;ECI2_8521;ECI1_8520;ECH1_8516;DECR1_8458;DAO_8437;CYP2J4_32580;CYP2E1_8421;CYP2D3_8420;CYP2C24_32875;CYP2C13_8419;CYP2C11_32593;CYP2A1_32717;CRAT_8375;CPT2_8374;APOA2_33095;ANXA7_8051;ANGPTL3_8045;AKR7A3_8015;ACOX1_7973;ACOT4_7971;ACOT2_7969 25.307564285714285 14.54955 24.46234770269629 16.89060339285714 8.63819 16.220612615264844 41.365385714285715 29.68235 32.85909844149336 12.54415;59.2729;15.4629;15.9021;6.44145;34.0134;7.29984;8.72912;11.7653;9.87438;21.6199;6.1336;16.3155;7.89174;12.8059;58.9435;104.635;54.426;9.37187;8.98517;31.2175;3.54778;64.7676;58.0729;18.819;23.8014;12.3157;13.6362 7.348245;45.3114;7.69418;10.4227;2.66377;26.1579;5.26587;5.10151;8.40998;6.59127;17.4928;2.43617;8.2378;4.16797;8.8664;48.1505;49.2461;43.9518;4.95906;1.97988;24.8356;1.51564;43.3787;40.0757;11.5469;19.0993;6.70485;11.3249 25.495849999999997;91.5578;35.0879;31.2818;17.3473;48.3681;11.8779;17.7951;18.8402;19.44;28.0829;16.2027;36.8422;15.8079;22.6004;80.4167;108.327;74.8861;19.1079;31.3726;42.0237;8.55785;127.439;105.112;51.6405;31.3543;24.3993;16.9658 3 24950;64515;170465 SRD5A1_32503;CDC20_8255;ACAA2_7955 69.7255 78.3988 36.95162856614036 39.363033333333334 43.6084 14.774321466765686 197.3093 98.7727 223.52296502245582 29.2087;101.569;78.3988 22.9308;51.5499;43.6084 39.9852;453.17;98.7727 0 Exp 2,5(0.16);Exp 4,6(0.19);Hill,7(0.22);Linear,7(0.22);Poly 2,6(0.19);Power,1(0.04) 2.0653395490219157 69.69206655025482 1.5293418169021606 4.473705768585205 0.7948920766429005 1.80877685546875 19.60086601638156 39.611282370715216 12.999016524699623 25.131692830139084 28.077437877222117 84.8360266389069 UP 0.9032258064516129 0.0967741935483871 0.0 GO:0010817 4 regulation of hormone levels 159 176 10 10 8 10 8 8 88 168 2283 0.78505 0.34354 0.53743 4.55 360268;64305;78968;24950;299270;25664;24484;499353 sult1e1;sult1b1;srebf1;srd5a1;serpina6;pparg;igfbp3;cyp2c24 SULT1E1_32446;SULT1B1_32942;SREBF1_32750;SRD5A1_32503;SERPINA6_32325;PPARG_32510;IGFBP3_8881;CYP2C24_32875 25664(0.0441) 47.9512375 54.94475 15.4629 18.038218796681807 48.727302982320275 18.763186488873902 34.09411 36.638000000000005 7.69418 13.422646934648501 34.24120393237877 14.075678923717843 72.8466375 82.74915 35.0879 24.7825775590686 74.14298320508806 24.73039431239197 59.2729;15.4629;41.2009;29.2087;68.3847;60.1903;50.946;58.9435 45.3114;7.69418;31.4864;22.9308;36.9679;43.9036;36.3081;48.1505 91.5578;35.0879;60.0774;39.9852;89.5095;101.057;85.0816;80.4167 6 2 6 360268;64305;78968;299270;25664;499353 SULT1E1_32446;SULT1B1_32942;SREBF1_32750;SERPINA6_32325;PPARG_32510;CYP2C24_32875 50.57586666666666 59.1082 19.370379333164003 35.585663333333336 40.43575 14.955283515683231 76.28438333333334 84.9631 24.489818671718787 59.2729;15.4629;41.2009;68.3847;60.1903;58.9435 45.3114;7.69418;31.4864;36.9679;43.9036;48.1505 91.5578;35.0879;60.0774;89.5095;101.057;80.4167 2 24950;24484 SRD5A1_32503;IGFBP3_8881 40.077349999999996 40.077349999999996 15.370592234686345 29.61945 29.61945 9.459179543966815 62.5334 62.5334 31.887970247101 29.2087;50.946 22.9308;36.3081 39.9852;85.0816 0 Exp 2,4(0.5);Exp 4,1(0.13);Linear,2(0.25);Poly 2,1(0.13) 1.9814161324079673 16.25570797920227 1.5239794254302979 2.9455835819244385 0.5123392962179121 1.890824317932129 35.45138960497286 60.45108539502712 24.792690224416482 43.39552977558352 55.67318742564702 90.02008757435297 UP 0.75 0.25 0.0 GO:0097176 5 epoxide metabolic process 2 2 2 2 2 2 2 2 94 0 2451 1.0 0.0014064 0.0014064 100.0 65030;25315 ephx2;ephx1 EPHX2_33282;EPHX1_8567 20.227424999999997 20.227424999999997 6.44145 19.49631281553643 18.228689159698995 19.290316832095904 14.410835 14.410835 2.66377 16.612858641078304 12.707707014214048 16.437328930106478 32.8577 32.8577 17.3473 21.935018037831647 30.60895137123746 21.703254952409257 0.0 6.44145 0.0 6.44145 6.44145;34.0134 2.66377;26.1579 17.3473;48.3681 2 0 2 65030;25315 EPHX2_33282;EPHX1_8567 20.227424999999997 20.227424999999997 19.49631281553643 14.410835 14.410835 16.612858641078304 32.8577 32.8577 21.935018037831647 6.44145;34.0134 2.66377;26.1579 17.3473;48.3681 0 0 Exp 4,1(0.5);Linear,1(0.5) 2.1790883730078057 4.374170541763306 2.000227451324463 2.3739430904388428 0.26425686265324255 2.187085270881653 -6.793085999999999 47.247935999999996 -8.6134124 37.4350824 2.4573160000000094 63.258084 UP 1.0 0.0 0.0 GO:0007267 3 cell-cell signaling 69 71 2 2 2 2 2 2 94 69 2382 0.49403 0.75718 1.0 2.82 25460;58868 hmmr;fzd1 HMMR_8814;FZD1_8671 64.402 64.402 25.231 55.396159451716485 62.96328080422329 55.35878120182385 36.31855 36.31855 13.6792 32.01687581331133 35.48702495787936 31.995272604771678 278.22249999999997 278.22249999999997 131.659 207.27208944886914 272.8393410086487 207.1322337615459 103.573;25.231 58.9579;13.6792 424.786;131.659 1 1 1 58868 FZD1_8671 25.231 25.231 13.6792 13.6792 131.659 131.659 25.231 13.6792 131.659 1 25460 HMMR_8814 103.573 103.573 58.9579 58.9579 424.786 424.786 103.573 58.9579 424.786 0 Linear,1(0.5);Poly 2,1(0.5) 1.5259418887902667 3.0520049333572388 1.5124053955078125 1.5395995378494263 0.019229162458307313 1.5260024666786194 -12.373159999999984 141.17716 -8.05457599999999 80.691676 -9.04195999999996 565.48696 CONFLICT 0.5 0.5 0.0 GO:2000230 8 negative regulation of pancreatic stellate cell proliferation 1 1 1 1 1 1 1 1 95 0 2451 1.0 0.037691 0.037691 100.0 25664 pparg PPARG_32510 25664(0.0441) 60.1903 60.1903 60.1903 60.1903 43.9036 43.9036 43.9036 43.9036 101.057 101.057 101.057 101.057 0.0 60.1903 0.0 60.1903 60.1903 43.9036 101.057 1 0 1 25664 PPARG_32510 60.1903 60.1903 43.9036 43.9036 101.057 101.057 60.1903 43.9036 101.057 0 0 Exp 2,1(1) 1.5239794254302979 1.5239794254302979 1.5239794254302979 1.5239794254302979 0.0 1.5239794254302979 60.1903 60.1903 43.9036 43.9036 101.057 101.057 UP 1.0 0.0 0.0 GO:0098813 4 nuclear chromosome segregation 19 19 4 4 4 4 4 4 92 15 2436 0.99948 0.004752 0.004752 21.05 257644;360243;304951;303575 zwint;top2a;nuf2;kif18b ZWINT_10214;TOP2A_10059;NUF2_33136;KIF18B_32882 45.001575000000145 57.012 5.73955E-13 30.343991653194685 53.625028547263355 23.560534155711256 25.841875000000144 29.70615 5.73955E-13 20.512016541753194 32.81952221595722 17.612770539201694 114.66075000000015 120.059 5.73957E-13 89.95367975936257 124.18451423738378 69.67634068559437 0.0 5.73955E-13 0.5 27.47885000000029 59.0663;54.9577;5.73955E-13;65.9823 40.5797;18.8326;5.73955E-13;43.9552 108.188;218.525;5.73957E-13;131.93 1 3 1 257644 ZWINT_10214 59.0663 59.0663 40.5797 40.5797 108.188 108.188 59.0663 40.5797 108.188 3 360243;304951;303575 TOP2A_10059;NUF2_33136;KIF18B_32882 40.313333333333524 54.9577 35.34485938044329 20.92926666666686 18.8326 22.05248081494055 116.81833333333354 131.93 110.04347212957825 54.9577;5.73955E-13;65.9823 18.8326;5.73955E-13;43.9552 218.525;5.73957E-13;131.93 0 Exp 2,1(0.25);Hill,1(0.25);Linear,2(0.5) 1.7326753264475077 6.944224238395691 1.5678966045379639 1.84699547290802 0.12336500207398624 1.7646660804748535 15.264463179869345 74.73868682013094 5.740098789082012 45.943651210918276 26.506143835824815 202.81535616417548 DOWN 0.25 0.75 0.0 GO:0071310 5 cellular response to organic substance 516 551 18 18 13 18 13 13 83 538 1913 0.028598 0.98553 0.057162 2.36 286954;78968;24950;25664;24614;24484;63868;24471;58868;25315;114494;25612;65155 ugt2b1;srebf1;srd5a1;pparg;orm1;igfbp3;hspd1;hspb1;fzd1;ephx1;ccna2;asns;alas1 UGT2B10_33303,UGT2B1_33224;SREBF1_32750;SRD5A1_32503;PPARG_32510;ORM1_9400;IGFBP3_8881;HSPD1_8849;HSPB1_8847;FZD1_8671;EPHX1_8567;CCNA2_8221;ASNS_8091;ALAS1_8018 25664(0.0441) 35.52801153846154 34.0134 12.54415 13.363302173928817 36.60891284900642 13.958517131942113 26.24579576923077 26.1579 7.348245 9.941948022175994 27.107918932754032 10.36315961642616 61.349319230769225 48.4857 25.495849999999997 31.80986406350985 62.029136376042665 31.184608442503855 12.54415;41.2009;29.2087;60.1903;24.2519;50.946;34.4455;41.6322;25.231;34.0134;52.8265;28.1893;27.1843 7.348245;31.4864;22.9308;43.9036;19.7133;36.3081;26.6907;30.9494;13.6792;26.1579;37.3288;23.1774;21.5215 25.495849999999997;60.0774;39.9852;101.057;31.358;85.0816;48.4857;63.3196;131.659;48.3681;90.0448;35.9474;36.6615 11 3 10 286954;78968;25664;24614;63868;24471;58868;25315;25612;65155 UGT2B10_33303,UGT2B1_33224;SREBF1_32750;PPARG_32510;ORM1_9400;HSPD1_8849;HSPB1_8847;FZD1_8671;EPHX1_8567;ASNS_8091;ALAS1_8018 32.888295 31.101349999999996 12.894302515677436 24.462764500000002 24.667650000000002 10.106344621492983 58.24295500000001 48.4269 33.6696980086319 12.54415;41.2009;60.1903;24.2519;34.4455;41.6322;25.231;34.0134;28.1893;27.1843 7.348245;31.4864;43.9036;19.7133;26.6907;30.9494;13.6792;26.1579;23.1774;21.5215 25.495849999999997;60.0774;101.057;31.358;48.4857;63.3196;131.659;48.3681;35.9474;36.6615 3 24950;24484;114494 SRD5A1_32503;IGFBP3_8881;CCNA2_8221 44.32706666666667 50.946 13.126607637288968 32.189233333333334 36.3081 8.034263996367907 71.70386666666667 85.0816 27.581038774733106 29.2087;50.946;52.8265 22.9308;36.3081;37.3288 39.9852;85.0816;90.0448 0 Exp 2,5(0.36);Exp 4,1(0.08);Linear,6(0.43);Poly 2,2(0.15) 1.9665116190872296 28.516989588737488 1.5124053955078125 3.5849626064300537 0.6267060607852044 1.8430557250976562 28.263637727128092 42.792385349794976 20.841291260843953 31.65030027761759 44.05728014960099 78.64135831193747 UP 0.7692307692307693 0.23076923076923078 0.0 GO:1905786 12 positive regulation of anaphase-promoting complex-dependent catabolic process 1 1 1 1 1 1 1 1 95 0 2451 1.0 0.037691 0.037691 100.0 64515 cdc20 CDC20_8255 101.569 101.569 101.569 101.569 51.5499 51.5499 51.5499 51.5499 453.17 453.17 453.17 453.17 0.0 101.569 0.0 101.569 101.569 51.5499 453.17 0 1 0 1 64515 CDC20_8255 101.569 101.569 51.5499 51.5499 453.17 453.17 101.569 51.5499 453.17 0 Exp 2,1(1) 1.5293418169021606 1.5293418169021606 1.5293418169021606 1.5293418169021606 0.0 1.5293418169021606 101.569 101.569 51.5499 51.5499 453.17 453.17 DOWN 0.0 1.0 0.0 GO:0032868 6 response to insulin 96 102 7 7 5 7 5 5 91 97 2354 0.81603 0.33939 0.434 4.9 78968;24950;25664;24484;65155 srebf1;srd5a1;pparg;igfbp3;alas1 SREBF1_32750;SRD5A1_32503;PPARG_32510;IGFBP3_8881;ALAS1_8018 25664(0.0441) 41.74604 41.2009 27.1843 14.092163910060073 44.44550520234987 13.782610389130939 31.230079999999997 31.4864 21.5215 9.34885916018634 33.15532965078329 9.198386153289315 64.57254 60.0774 36.6615 28.0869502142543 69.4445116351175 27.620044271863627 41.2009;29.2087;60.1903;50.946;27.1843 31.4864;22.9308;43.9036;36.3081;21.5215 60.0774;39.9852;101.057;85.0816;36.6615 3 2 3 78968;25664;65155 SREBF1_32750;PPARG_32510;ALAS1_8018 42.8585 41.2009 16.56531730212252 32.30383333333333 31.4864 11.213418214056485 65.93196666666667 60.0774 32.594509786209876 41.2009;60.1903;27.1843 31.4864;43.9036;21.5215 60.0774;101.057;36.6615 2 24950;24484 SRD5A1_32503;IGFBP3_8881 40.077349999999996 40.077349999999996 15.370592234686345 29.61945 29.61945 9.459179543966815 62.5334 62.5334 31.887970247101 29.2087;50.946 22.9308;36.3081 39.9852;85.0816 0 Exp 2,2(0.4);Linear,3(0.6) 1.7861652053709862 8.96508538722992 1.5239794254302979 1.9512832164764404 0.170941500108075 1.8392632007598877 29.393713710438277 54.098366289561724 23.03544363905469 39.42471636094532 39.95324265578783 89.19183734421215 UP 0.6 0.4 0.0 GO:0032368 6 regulation of lipid transport 41 44 6 6 4 6 4 4 92 40 2411 0.97677 0.081586 0.081586 9.09 296371;24484;25649;114628 pltp;igfbp3;apoa2;abcg5 PLTP_32412;IGFBP3_8881;APOA2_33095;ABCG5_7947 43.65782 42.028949999999995 3.54778 34.899444347481136 44.047761247187154 34.99145858201818 29.665035000000003 30.258950000000002 1.51564 23.04491504008856 29.908988608261186 22.927587650502687 62.158837500000004 67.75725 8.55785 42.166849179526764 61.698774055074566 41.34364657988427 1.5 42.028949999999995 87.0256;50.946;3.54778;33.1119 56.6266;36.3081;1.51564;24.2098 104.563;85.0816;8.55785;50.4329 2 2 2 296371;25649 PLTP_32412;APOA2_33095 45.28669 45.28669 59.02773260066999 29.07112 29.07112 38.96933353370057 56.560425 56.560425 67.88589259383167 87.0256;3.54778 56.6266;1.51564 104.563;8.55785 2 24484;114628 IGFBP3_8881;ABCG5_7947 42.028949999999995 42.028949999999995 12.610613046359013 30.258950000000002 30.258950000000002 8.554789970829193 67.75725 67.75725 24.50033072929834 50.946;33.1119 36.3081;24.2098 85.0816;50.4329 0 Exp 2,1(0.25);Hill,1(0.25);Linear,1(0.25);Poly 2,1(0.25) 1.839855308401539 7.504646897315979 1.5084086656570435 2.5319817066192627 0.4497786449039252 1.7321282625198364 9.456364539468481 77.8592754605315 7.081018260713208 52.24905173928679 20.83532530406375 103.48234969593625 CONFLICT 0.5 0.5 0.0 GO:0033488 8 cholesterol biosynthetic process via 24,25-dihydrolanosterol 1 1 1 1 1 1 1 1 95 0 2451 1.0 0.037691 0.037691 100.0 25427 cyp51 CYP51_8429 75.1522 75.1522 75.1522 75.1522 48.098 48.098 48.098 48.098000000000006 171.379 171.379 171.379 171.379 0.0 75.1522 0.0 75.1522 75.1522 48.098 171.379 0 1 0 1 25427 CYP51_8429 75.1522 75.1522 48.098 48.098 171.379 171.379 75.1522 48.098 171.379 0 Linear,1(1) 1.633623480796814 1.633623480796814 1.633623480796814 1.633623480796814 0.0 1.633623480796814 75.1522 75.1522 48.098 48.098 171.379 171.379 DOWN 0.0 1.0 0.0 GO:0030224 7 monocyte differentiation 8 8 2 2 2 2 2 2 94 6 2445 0.99747 0.033945 0.033945 25.0 25664;363465 pparg;pir PPARG_32510;PIR_9487 25664(0.0441) 56.1755 56.1755 52.1607 5.677784610215482 56.56379599640126 5.651167181950842 42.434 42.434 40.9644 2.0783282512634984 42.576134053081425 2.0685850579342704 87.98335 87.98335 74.9097 18.488933139719023 89.24778308591993 18.402257105786283 0.0 52.1607 0.0 52.1607 60.1903;52.1607 43.9036;40.9644 101.057;74.9097 2 0 2 25664;363465 PPARG_32510;PIR_9487 56.1755 56.1755 5.677784610215482 42.434 42.434 2.0783282512634984 87.98335 87.98335 18.488933139719023 60.1903;52.1607 43.9036;40.9644 101.057;74.9097 0 0 Exp 2,2(1) 1.6826030619092303 3.38171648979187 1.5239794254302979 1.8577370643615723 0.2360022897611154 1.690858244895935 48.306492 64.04450800000001 39.553584 45.314415999999994 62.358996000000005 113.607704 UP 1.0 0.0 0.0 GO:0043279 6 response to alkaloid 71 74 3 3 3 3 3 3 93 71 2380 0.69614 0.53429 0.75691 4.05 25664;63868;114494 pparg;hspd1;ccna2 PPARG_32510;HSPD1_8849;CCNA2_8221 25664(0.0441) 49.1541 52.8265 34.4455 13.259471070898718 50.69353440089585 13.705777197631182 35.97436666666666 37.3288 26.6907 8.686014554635157 37.199402536394174 9.11837678042565 79.8625 90.0448 48.4857 27.72534618160796 82.52890327547593 28.261088577939738 60.1903;34.4455;52.8265 43.9036;26.6907;37.3288 101.057;48.4857;90.0448 2 1 2 25664;63868 PPARG_32510;HSPD1_8849 47.3179 47.3179 18.204322660291428 35.29715 35.29715 12.171358313885893 74.77135 74.77135 37.173522725792346 60.1903;34.4455 43.9036;26.6907 101.057;48.4857 1 114494 CCNA2_8221 52.8265 52.8265 37.3288 37.3288 90.0448 90.0448 52.8265 37.3288 90.0448 0 Exp 2,2(0.67);Linear,1(0.34) 1.8037286618385113 5.505346894264221 1.5239794254302979 2.3255980014801025 0.4298509861467661 1.6557694673538208 34.14959598349296 64.15860401650704 26.145215897711616 45.80351743562172 48.4883172805993 111.2366827194007 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0030336 7 negative regulation of cell migration 73 78 4 4 3 3 3 3 93 75 2376 0.66134 0.57062 1.0 3.85 25664;24484;25599 pparg;igfbp3;cd74 PPARG_32510;IGFBP3_8881;CD74_8252 25664(0.0441) 68.68336666666666 60.1903 50.946 23.181695262929626 71.16748813235019 22.990005151150243 46.342099999999995 43.9036 36.3081 11.449687648578019 47.79948034347582 11.055195607112525 101.6372 101.057 85.0816 16.85319205729281 104.11764926264698 15.792867764172346 60.1903;50.946;94.9138 43.9036;36.3081;58.8146 101.057;85.0816;118.773 2 1 2 25664;25599 PPARG_32510;CD74_8252 77.55205 77.55205 24.55322231653108 51.3591 51.3591 10.543669214272617 109.91499999999999 109.91499999999999 12.527103735500948 60.1903;94.9138 43.9036;58.8146 101.057;118.773 1 24484 IGFBP3_8881 50.946 50.946 36.3081 36.3081 85.0816 85.0816 50.946 36.3081 85.0816 0 Exp 2,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 1.6375011166713265 4.919717788696289 1.5239794254302979 1.7380040884017944 0.10812042597069588 1.6577342748641968 42.45080898603108 94.91592434730227 33.38555871775445 59.298641282245555 82.56601785687427 120.70838214312572 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0048511 2 rhythmic process 111 122 8 7 6 8 5 5 91 117 2334 0.68936 0.49124 0.80586 4.1 360243;78968;24950;25664;259241 top2a;srebf1;srd5a1;pparg;nr1d2 TOP2A_10059;SREBF1_32750;SRD5A1_32503;PPARG_32510;NR1D2_9358 25664(0.0441) 56.9162 54.9577 29.2087 26.468131570059864 54.197018157466424 21.955275054730404 31.94182 31.4864 18.8326 11.280471701662119 33.28899213685067 10.658334552435171 104.49651999999999 101.057 39.9852 69.19509351689616 99.20677812966227 62.84069596825017 54.9577;41.2009;29.2087;60.1903;99.0234 18.8326;31.4864;22.9308;43.9036;42.5557 218.525;60.0774;39.9852;101.057;102.838 3 2 3 78968;25664;259241 SREBF1_32750;PPARG_32510;NR1D2_9358 66.80486666666667 60.1903 29.47328868150503 39.31523333333333 42.5557 6.813382575735285 87.9908 101.057 24.19010985754301 41.2009;60.1903;99.0234 31.4864;43.9036;42.5557 60.0774;101.057;102.838 2 360243;24950 TOP2A_10059;SRD5A1_32503 42.083200000000005 42.083200000000005 18.207292508772387 20.881700000000002 20.881700000000002 2.897865010658708 129.2551 129.2551 126.24670329168998 54.9577;29.2087 18.8326;22.9308 218.525;39.9852 0 Exp 2,3(0.6);Linear,1(0.2);Power,1(0.2) 1.9474666964125515 9.920976638793945 1.5239794254302979 2.7270524501800537 0.44765126934108074 1.912555456161499 33.71585976019966 80.11654023980034 22.05405059507374 41.82958940492626 43.84434633721198 165.148693662788 UP 0.6 0.4 0.0 GO:0019532 9 oxalate transport 3 3 1 1 1 1 1 1 95 2 2449 0.99588 0.10891 0.10891 33.33 117267 slc26a2 SLC26A2_33072 54.7452 54.7452 54.7452 54.7452 38.3503 38.3503 38.3503 38.3503 95.3373 95.3373 95.3373 95.3373 0.0 54.7452 0.0 54.7452 54.7452 38.3503 95.3373 0 1 0 1 117267 SLC26A2_33072 54.7452 54.7452 38.3503 38.3503 95.3373 95.3373 54.7452 38.3503 95.3373 0 Linear,1(1) 1.5239086151123047 1.5239086151123047 1.5239086151123047 1.5239086151123047 0.0 1.5239086151123047 54.7452 54.7452 38.3503 38.3503 95.3373 95.3373 DOWN 0.0 1.0 0.0 GO:0006104 8 succinyl-CoA metabolic process 1 1 1 1 1 1 1 1 95 0 2451 1.0 0.037691 0.037691 100.0 681337 acot4 ACOT4_7971 12.3157 12.3157 12.3157 12.3157 6.70485 6.70485 6.70485 6.70485 24.3993 24.3993 24.3993 24.3993 0.0 12.3157 0.0 12.3157 12.3157 6.70485 24.3993 1 0 1 681337 ACOT4_7971 12.3157 12.3157 6.70485 6.70485 24.3993 24.3993 12.3157 6.70485 24.3993 0 0 Hill,1(1) 2.854028940200806 2.8540289402008057 2.8540289402008057 2.8540289402008057 0.0 2.8540289402008057 12.3157 12.3157 6.70485 6.70485 24.3993 24.3993 UP 1.0 0.0 0.0 GO:0019605 8 butyrate metabolic process 1 1 1 1 1 1 1 1 95 0 2451 1.0 0.037691 0.037691 100.0 681337 acot4 ACOT4_7971 12.3157 12.3157 12.3157 12.3157 6.70485 6.70485 6.70485 6.70485 24.3993 24.3993 24.3993 24.3993 0.0 12.3157 0.0 12.3157 12.3157 6.70485 24.3993 1 0 1 681337 ACOT4_7971 12.3157 12.3157 6.70485 6.70485 24.3993 24.3993 12.3157 6.70485 24.3993 0 0 Hill,1(1) 2.854028940200806 2.8540289402008057 2.8540289402008057 2.8540289402008057 0.0 2.8540289402008057 12.3157 12.3157 6.70485 6.70485 24.3993 24.3993 UP 1.0 0.0 0.0 GO:0050767 7 regulation of neurogenesis 202 215 7 7 5 7 5 5 91 210 2241 0.16487 0.91972 0.34674 2.33 25664;338475;24471;58868;64515 pparg;nrep;hspb1;fzd1;cdc20 PPARG_32510;NREP_9364;HSPB1_8847;FZD1_8671;CDC20_8255 25664(0.0441) 59.60658000000001 60.1903 25.231 28.991633036998763 60.15921516378719 26.101590998477906 36.645779999999995 43.1468 13.6792 14.806962443121149 37.98037912407328 13.406743320996911 181.42991999999998 131.659 63.3196 155.94971782126444 168.11738240961492 144.48832357749984 60.1903;69.4104;41.6322;25.231;101.569 43.9036;43.1468;30.9494;13.6792;51.5499 101.057;157.944;63.3196;131.659;453.17 3 2 3 25664;24471;58868 PPARG_32510;HSPB1_8847;FZD1_8671 42.35116666666667 41.6322 17.490736088665123 29.51073333333333 30.9494 15.163472892887478 98.67853333333333 101.057 34.23172835036719 60.1903;41.6322;25.231 43.9036;30.9494;13.6792 101.057;63.3196;131.659 2 338475;64515 NREP_9364;CDC20_8255 85.4897 85.4897 22.739564133465684 47.348349999999996 47.348349999999996 5.941888992988682 305.557 305.557 208.75630658257967 69.4104;101.569 43.1468;51.5499 157.944;453.17 0 Exp 2,3(0.6);Linear,1(0.2);Poly 2,1(0.2) 1.705164982384889 8.626938462257385 1.5124053955078125 2.2143635749816895 0.3074942335861044 1.5293418169021606 34.19429319821248 85.01886680178752 23.66690517126275 49.62465482873725 44.733965312859 318.12587468714094 UP 0.6 0.4 0.0 GO:1903827 6 regulation of cellular protein localization 137 147 3 3 2 3 2 2 94 145 2306 0.075812 0.97885 0.17446 1.36 78968;362485 srebf1;ccne2 SREBF1_32750;CCNE2_8227 59.545100000000005 59.545100000000005 41.2009 25.942616430884517 49.44962347856457 21.66061067676282 40.3768 40.3768 31.4864 12.572924254921748 35.48409143455863 10.49767736727098 122.76920000000001 122.76920000000001 60.0774 88.65959380958162 88.26763574609274 74.02572324906403 41.2009;77.8893 31.4864;49.2672 60.0774;185.461 1 1 1 78968 SREBF1_32750 41.2009 41.2009 31.4864 31.4864 60.0774 60.0774 41.2009 31.4864 60.0774 1 362485 CCNE2_8227 77.8893 77.8893 49.2672 49.2672 185.461 185.461 77.8893 49.2672 185.461 0 Exp 2,1(0.5);Linear,1(0.5) 1.7437164762073278 3.50233793258667 1.589782476425171 1.912555456161499 0.22823496275534572 1.751168966293335 23.590468 95.49973200000001 22.951616 57.801984000000004 -0.10672799999998972 245.645128 CONFLICT 0.5 0.5 0.0 GO:0071363 6 cellular response to growth factor stimulus 136 141 4 4 4 4 4 4 92 137 2314 0.37694 0.78984 0.8184 2.84 24950;24471;58868;114494 srd5a1;hspb1;fzd1;ccna2 SRD5A1_32503;HSPB1_8847;FZD1_8671;CCNA2_8221 37.2246 35.42045 25.231 12.529263281613964 37.1402400154372 12.007892616605035 26.22205 26.9401 13.6792 10.228443124770594 26.17050796118646 10.037332774808592 81.25215 76.6822 39.9852 39.33911849863948 81.31423454625647 38.87208641231971 29.2087;41.6322;25.231;52.8265 22.9308;30.9494;13.6792;37.3288 39.9852;63.3196;131.659;90.0448 2 2 2 24471;58868 HSPB1_8847;FZD1_8671 33.4316 33.4316 11.597399739596785 22.3143 22.3143 12.21187553244792 97.4893 97.4893 48.323253162219935 41.6322;25.231 30.9494;13.6792 63.3196;131.659 2 24950;114494 SRD5A1_32503;CCNA2_8221 41.0176 41.0176 16.700306536707636 30.129800000000003 30.129800000000003 10.180923435523901 65.015 65.015 35.39748262348606 29.2087;52.8265 22.9308;37.3288 39.9852;90.0448 0 Linear,3(0.75);Poly 2,1(0.25) 1.8868553005092414 7.63613486289978 1.5124053955078125 2.3255980014801025 0.334908883676523 1.8990657329559326 24.945921984018312 49.50327801598169 16.198175737724824 36.245924262275174 42.699813871333305 119.8044861286667 CONFLICT 0.5 0.5 0.0 GO:0042632 8 cholesterol homeostasis 34 35 8 8 6 8 6 6 90 29 2422 0.99975 0.00164 0.00164 17.14 65035;65030;25649;502970;50681;114628 nr1i3;ephx2;apoa2;angptl3;acox1;abcg5 NR1I3_32602;EPHX2_33282;APOA2_33095;ANGPTL3_8045;ACOX1_7973;ABCG5_7947 24.51173833333333 22.9482 3.54778 19.862942517563123 27.9364729213342 22.11809938732336 16.75285166666667 16.0261 1.51564 14.492630036404591 18.847658002461444 16.04726492662801 44.77770833333333 40.8936 8.55785 34.755030078859335 52.05019280278294 38.213746598315765 0.5 4.994615 2.5 22.9482 22.095;6.44145;3.54778;58.0729;23.8014;33.1119 12.9529;2.66377;1.51564;40.0757;19.0993;24.2098 55.8619;17.3473;8.55785;105.112;31.3543;50.4329 5 1 5 65035;65030;25649;502970;50681 NR1I3_32602;EPHX2_33282;APOA2_33095;ANGPTL3_8045;ACOX1_7973 22.791705999999998 22.095 21.70211447329914 15.261462 12.9529 15.68003772895078 43.64667 31.3543 38.73365186620027 22.095;6.44145;3.54778;58.0729;23.8014 12.9529;2.66377;1.51564;40.0757;19.0993 55.8619;17.3473;8.55785;105.112;31.3543 1 114628 ABCG5_7947 33.1119 33.1119 24.2098 24.2098 50.4329 50.4329 33.1119 24.2098 50.4329 0 Exp 2,1(0.17);Exp 4,1(0.17);Hill,1(0.17);Linear,2(0.34);Poly 2,1(0.17) 1.9308844933850764 11.807709574699402 1.5375925302505493 2.5319817066192627 0.42228017619899355 1.8954042792320251 8.618074173634172 40.40540249303249 5.156332450759345 28.349370882573993 16.967892368492993 72.58752429817366 UP 0.8333333333333334 0.16666666666666666 0.0 GO:0046395 6 carboxylic acid catabolic process 80 87 16 16 13 16 13 13 83 74 2377 1.0 1.3984E-5 1.3984E-5 14.94 364975;171142;291075;29740;64526;117543;114027;311849;25413;50681;681337;192272;170465 gcdh;ehhadh;eci2;eci1;ech1;decr1;dao;crat;cpt2;acox1;acot4;acot2;acaa2 GCDH_8693;EHHADH_8534;ECI2_8521;ECI1_8520;ECH1_8516;DECR1_8458;DAO_8437;CRAT_8375;CPT2_8374;ACOX1_7973;ACOT4_7971;ACOT2_7969;ACAA2_7955 19.20607769230769 12.3157 6.1336 19.221820925198596 21.588450550151006 22.03511101863407 12.559479230769231 8.40998 1.97988 11.540787964073669 13.902800001430615 12.69347331591379 29.877615384615385 24.3993 11.8779 22.338576278560744 32.56730331425845 25.717017219581127 3.5 9.429775 7.5 14.76915 15.9021;7.29984;8.72912;11.7653;9.87438;21.6199;6.1336;8.98517;31.2175;23.8014;12.3157;13.6362;78.3988 10.4227;5.26587;5.10151;8.40998;6.59127;17.4928;2.43617;1.97988;24.8356;19.0993;6.70485;11.3249;43.6084 31.2818;11.8779;17.7951;18.8402;19.44;28.0829;16.2027;31.3726;42.0237;31.3543;24.3993;16.9658;98.7727 12 1 12 364975;171142;291075;29740;64526;117543;114027;311849;25413;50681;681337;192272 GCDH_8693;EHHADH_8534;ECI2_8521;ECI1_8520;ECH1_8516;DECR1_8458;DAO_8437;CRAT_8375;CPT2_8374;ACOX1_7973;ACOT4_7971;ACOT2_7969 14.273350833333332 12.0405 7.61565905216048 9.972069166666666 7.557415 7.096130001427101 24.136358333333334 21.91965 8.77012909270162 15.9021;7.29984;8.72912;11.7653;9.87438;21.6199;6.1336;8.98517;31.2175;23.8014;12.3157;13.6362 10.4227;5.26587;5.10151;8.40998;6.59127;17.4928;2.43617;1.97988;24.8356;19.0993;6.70485;11.3249 31.2818;11.8779;17.7951;18.8402;19.44;28.0829;16.2027;31.3726;42.0237;31.3543;24.3993;16.9658 1 170465 ACAA2_7955 78.3988 78.3988 43.6084 43.6084 98.7727 98.7727 78.3988 43.6084 98.7727 0 Exp 2,1(0.08);Hill,6(0.47);Linear,3(0.24);Poly 2,3(0.24) 2.3060812896851943 32.314518451690674 1.5464483499526978 4.473705768585205 1.0451674035082634 1.8769218921661377 8.756976810074095 29.65517857454129 6.285835429469112 18.83312303206935 17.73422699240769 42.02100377682308 UP 0.9230769230769231 0.07692307692307693 0.0 GO:0030258 5 lipid modification 64 70 16 16 14 16 14 14 82 56 2395 1.0 1.5341E-7 1.5341E-7 20.0 25664;364975;65030;171142;291075;29740;64526;117543;50549;25086;311849;25413;50681;170465 pparg;gcdh;ephx2;ehhadh;eci2;eci1;ech1;decr1;cyp4a1;cyp2e1;crat;cpt2;acox1;acaa2 PPARG_32510;GCDH_8693;EPHX2_33282;EHHADH_8534;ECI2_8521;ECI1_8520;ECH1_8516;DECR1_8458;CYP4A1_33111;CYP2E1_8421;CRAT_8375;CPT2_8374;ACOX1_7973;ACAA2_7955 25664(0.0441) 22.523214285714285 13.8337 6.44145 21.5138141063803 25.433326547414506 24.778984387364485 15.171832142857141 9.41634 1.97988 14.019175120592827 16.68388649074433 16.10574774629427 35.359907142857146 29.0341 11.8779 28.561833623277614 40.428187647564144 33.319315038357914 2.5 8.31043 6.0 11.7653 60.1903;15.9021;6.44145;7.29984;8.72912;11.7653;9.87438;21.6199;23.208;7.89174;8.98517;31.2175;23.8014;78.3988 43.9036;10.4227;2.66377;5.26587;5.10151;8.40998;6.59127;17.4928;18.863;4.16797;1.97988;24.8356;19.0993;43.6084 101.057;31.2818;17.3473;11.8779;17.7951;18.8402;19.44;28.0829;29.9853;15.8079;31.3726;42.0237;31.3543;98.7727 13 1 13 25664;364975;65030;171142;291075;29740;64526;117543;50549;25086;311849;25413;50681 PPARG_32510;GCDH_8693;EPHX2_33282;EHHADH_8534;ECI2_8521;ECI1_8520;ECH1_8516;DECR1_8458;CYP4A1_33111;CYP2E1_8421;CRAT_8375;CPT2_8374;ACOX1_7973 18.225092307692307 11.7653 14.873727968980045 12.984403846153846 8.40998 11.846740687907607 30.482000000000003 28.0829 22.866668620942576 60.1903;15.9021;6.44145;7.29984;8.72912;11.7653;9.87438;21.6199;23.208;7.89174;8.98517;31.2175;23.8014 43.9036;10.4227;2.66377;5.26587;5.10151;8.40998;6.59127;17.4928;18.863;4.16797;1.97988;24.8356;19.0993 101.057;31.2818;17.3473;11.8779;17.7951;18.8402;19.44;28.0829;29.9853;15.8079;31.3726;42.0237;31.3543 1 170465 ACAA2_7955 78.3988 78.3988 43.6084 43.6084 98.7727 98.7727 78.3988 43.6084 98.7727 0 Exp 2,3(0.22);Exp 4,2(0.15);Hill,4(0.29);Linear,2(0.15);Poly 2,3(0.22) 2.0452318053908307 30.395506143569946 1.5239794254302979 3.9502921104431152 0.854915289934381 1.7989360690116882 11.253589280079586 33.792839291348976 7.828139122355037 22.51552516335925 20.398303736968842 50.32151054874544 UP 0.9285714285714286 0.07142857142857142 0.0 GO:0090092 6 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 55 58 4 4 3 3 3 3 93 55 2396 0.82714 0.37496 0.47992 5.17 338475;29455;58868 nrep;gdf15;fzd1 NREP_9364;GDF15_33113;FZD1_8671 38.668933333333335 25.231 21.3654 26.692958724227882 48.55085573040852 27.507322864183195 24.9045 17.8875 13.6792 15.937803461895246 29.891032975679543 17.51862965372836 105.31859999999999 131.659 26.3528 69.6378021155177 135.55368464473054 46.31036571056157 1.5 47.3207 69.4104;21.3654;25.231 43.1468;17.8875;13.6792 157.944;26.3528;131.659 2 1 2 29455;58868 GDF15_33113;FZD1_8671 23.2982 23.2982 2.7333919733547223 15.783349999999999 15.783349999999999 2.97571746726735 79.0059 79.0059 74.46272812098681 21.3654;25.231 17.8875;13.6792 26.3528;131.659 1 338475 NREP_9364 69.4104 69.4104 43.1468 43.1468 157.944 157.944 69.4104 43.1468 157.944 0 Exp 2,2(0.67);Poly 2,1(0.34) 2.5609319233190466 8.741838455200195 1.5124053955078125 5.015069484710693 1.8531664163584398 2.2143635749816895 8.463006999728286 68.87485966693839 6.869177566727529 42.939822433272475 26.51600855755065 184.12119144244934 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0019373 7 epoxygenase P450 pathway 10 13 6 6 6 6 6 6 90 7 2444 1.0 3.4018E-6 3.4018E-6 46.15 65210;25086;499353;171521;29277;24894 cyp2j4;cyp2e1;cyp2c24;cyp2c13;cyp2c11;cyp2a1 CYP2J4_32580;CYP2E1_8421;CYP2C24_32875;CYP2C13_8419;CYP2C11_32593;CYP2A1_32717 41.93060166666667 35.37075 7.89174 38.08481010653062 45.91058781318165 38.21017820868804 26.452205000000003 26.0948 4.16797 22.746078525197923 28.841436895556217 22.287288070372036 55.89796666666667 55.864149999999995 15.8079 37.508307671643436 60.458204631966126 36.4723135706048 0.0 7.89174 0.5 8.631805 16.3155;7.89174;58.9435;104.635;54.426;9.37187 8.2378;4.16797;48.1505;49.2461;43.9518;4.95906 36.8422;15.8079;80.4167;108.327;74.8861;19.1079 6 0 6 65210;25086;499353;171521;29277;24894 CYP2J4_32580;CYP2E1_8421;CYP2C24_32875;CYP2C13_8419;CYP2C11_32593;CYP2A1_32717 41.93060166666667 35.37075 38.08481010653062 26.452205000000003 26.0948 22.746078525197923 55.89796666666667 55.864149999999995 37.508307671643436 16.3155;7.89174;58.9435;104.635;54.426;9.37187 8.2378;4.16797;48.1505;49.2461;43.9518;4.95906 36.8422;15.8079;80.4167;108.327;74.8861;19.1079 0 0 Exp 2,2(0.34);Exp 4,3(0.5);Power,1(0.17) 2.184743148456464 13.497295498847961 1.5310101509094238 2.9415390491485596 0.5819843029906648 2.2902639508247375 11.456406774147986 72.40479655918534 8.251551561569077 44.652858438430926 25.885069795790237 85.9108635375431 UP 1.0 0.0 0.0 GO:0042108 7 positive regulation of cytokine biosynthetic process 31 34 3 3 3 3 3 3 93 31 2420 0.96303 0.13427 0.13427 8.82 24471;25599;25649 hspb1;cd74;apoa2 HSPB1_8847;CD74_8252;APOA2_33095 46.69792666666666 41.6322 3.54778 45.89317588330681 51.71434599929468 47.29804023426696 30.426546666666667 30.9494 1.51564 28.653058056279665 33.33449953750819 29.30528162294077 63.550149999999995 63.3196 8.55785 55.10793670023857 69.22316376391758 56.44414831034999 0.5 22.58999 41.6322;94.9138;3.54778 30.9494;58.8146;1.51564 63.3196;118.773;8.55785 3 0 3 24471;25599;25649 HSPB1_8847;CD74_8252;APOA2_33095 46.69792666666666 41.6322 45.89317588330681 30.426546666666667 30.9494 28.653058056279665 63.550149999999995 63.3196 55.10793670023857 41.6322;94.9138;3.54778 30.9494;58.8146;1.51564 63.3196;118.773;8.55785 0 0 Hill,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 1.7418742987017326 5.2308349609375 1.6577342748641968 1.8468482494354248 0.09574461162842911 1.7262524366378784 -5.235090735713634 98.63094406904696 -1.9974408658554594 62.85053419918879 1.1896491067995285 125.91065089320048 UP 1.0 0.0 0.0 GO:0006564 9 L-serine biosynthetic process 2 2 1 1 1 1 1 1 95 1 2450 0.99859 0.073976 0.073976 50.0 293820 psat1 PSAT1_9583 26.3316 26.3316 26.3316 26.331599999999998 20.9188 20.9188 20.9188 20.9188 35.2954 35.2954 35.2954 35.2954 0.0 26.3316 0.0 26.3316 26.3316 20.9188 35.2954 1 0 1 293820 PSAT1_9583 26.3316 26.3316 20.9188 20.9188 35.2954 35.2954 26.3316 20.9188 35.2954 0 0 Linear,1(1) 2.6224241256713867 2.6224241256713867 2.6224241256713867 2.6224241256713867 0.0 2.6224241256713867 26.3316 26.3316 20.9188 20.9188 35.2954 35.2954 UP 1.0 0.0 0.0 GO:0043436 5 oxoacid metabolic process 298 332 44 44 39 44 39 39 57 293 2158 1.0 4.633E-12 4.633E-12 11.75 29142;286954;360268;64305;293820;24679;25664;680308;291234;24552;364975;65030;25315;171142;291075;29740;64526;117543;114027;50549;65210;25086;24303;499353;171521;29277;24894;311849;25413;25599;25612;502970;24763;50681;681337;314304;192272;50559;170465 vnn1;ugt2b1;sult1e1;sult1b1;psat1;prkar2b;pparg;mthfd2;mki67;me1;gcdh;ephx2;ephx1;ehhadh;eci2;eci1;ech1;decr1;dao;cyp4a1;cyp2j4;cyp2e1;cyp2d3;cyp2c24;cyp2c13;cyp2c11;cyp2a1;crat;cpt2;cd74;asns;angptl3;acsm3;acox1;acot4;acot3;acot2;acot1;acaa2 VNN1_10157;UGT2B10_33303,UGT2B1_33224;SULT1E1_32446;SULT1B1_32942;PSAT1_9583;PRKAR2B_33052;PPARG_32510;MTHFD2_9261;MKI67_9232;ME1_9215;GCDH_8693;EPHX2_33282;EPHX1_8567;EHHADH_8534;ECI2_8521;ECI1_8520;ECH1_8516;DECR1_8458;DAO_8437;CYP4A1_33111;CYP2J4_32580;CYP2E1_8421;CYP2D3_8420;CYP2C24_32875;CYP2C13_8419;CYP2C11_32593;CYP2A1_32717;CRAT_8375;CPT2_8374;CD74_8252;ASNS_8091;ANGPTL3_8045;ACSM3_7976;ACOX1_7973;ACOT4_7971;ACOT3_7970;ACOT2_7969;ACOT1_7968;ACAA2_7955 25664(0.0441) 34.11090820512821 23.8014 6.1336 28.05599157618104 37.53412138214893 29.63561584546653 23.36300397435897 19.0993 1.97988 17.697727457438464 25.1347956517525 18.62820624465883 50.08737820512821 35.0879 11.8779 35.45424887944505 55.63473999127199 36.70075145866663 15.5 18.52415 32.5 59.1082 20.7328;12.54415;59.2729;15.4629;26.3316;108.746;60.1903;57.4184;49.7822;49.3339;15.9021;6.44145;34.0134;7.29984;8.72912;11.7653;9.87438;21.6199;6.1336;23.208;16.3155;7.89174;12.8059;58.9435;104.635;54.426;9.37187;8.98517;31.2175;94.9138;28.1893;58.0729;52.2057;23.8014;12.3157;30.8838;13.6362;28.5134;78.3988 16.8296;7.348245;45.3114;7.69418;20.9188;59.3814;43.9036;46.387;35.6665;35.4173;10.4227;2.66377;26.1579;5.26587;5.10151;8.40998;6.59127;17.4928;2.43617;18.863;8.2378;4.16797;8.8664;48.1505;49.2461;43.9518;4.95906;1.97988;24.8356;58.8146;23.1774;40.0757;42.2655;19.0993;6.70485;24.6874;11.3249;24.741;43.6084 26.7838;25.495849999999997;91.5578;35.0879;35.2954;147.467;101.057;79.7903;82.1147;80.9924;31.2818;17.3473;48.3681;11.8779;17.7951;18.8402;19.44;28.0829;16.2027;29.9853;36.8422;15.8079;22.6004;80.4167;108.327;74.8861;19.1079;31.3726;42.0237;118.773;35.9474;105.112;71.1126;31.3543;24.3993;41.2585;16.9658;33.4642;98.7727 38 2 37 29142;286954;360268;64305;293820;24679;25664;680308;24552;364975;65030;25315;171142;291075;29740;64526;117543;114027;50549;65210;25086;24303;499353;171521;29277;24894;311849;25413;25599;25612;502970;24763;50681;681337;314304;192272;50559 VNN1_10157;UGT2B10_33303,UGT2B1_33224;SULT1E1_32446;SULT1B1_32942;PSAT1_9583;PRKAR2B_33052;PPARG_32510;MTHFD2_9261;ME1_9215;GCDH_8693;EPHX2_33282;EPHX1_8567;EHHADH_8534;ECI2_8521;ECI1_8520;ECH1_8516;DECR1_8458;DAO_8437;CYP4A1_33111;CYP2J4_32580;CYP2E1_8421;CYP2D3_8420;CYP2C24_32875;CYP2C13_8419;CYP2C11_32593;CYP2A1_32717;CRAT_8375;CPT2_8374;CD74_8252;ASNS_8091;ANGPTL3_8045;ACSM3_7976;ACOX1_7973;ACOT4_7971;ACOT3_7970;ACOT2_7969;ACOT1_7968 32.490389729729735 23.208 27.692306139337738 22.483304189189187 18.863 17.72637539246271 47.905955405405415 33.4642 35.037307384985645 20.7328;12.54415;59.2729;15.4629;26.3316;108.746;60.1903;57.4184;49.3339;15.9021;6.44145;34.0134;7.29984;8.72912;11.7653;9.87438;21.6199;6.1336;23.208;16.3155;7.89174;12.8059;58.9435;104.635;54.426;9.37187;8.98517;31.2175;94.9138;28.1893;58.0729;52.2057;23.8014;12.3157;30.8838;13.6362;28.5134 16.8296;7.348245;45.3114;7.69418;20.9188;59.3814;43.9036;46.387;35.4173;10.4227;2.66377;26.1579;5.26587;5.10151;8.40998;6.59127;17.4928;2.43617;18.863;8.2378;4.16797;8.8664;48.1505;49.2461;43.9518;4.95906;1.97988;24.8356;58.8146;23.1774;40.0757;42.2655;19.0993;6.70485;24.6874;11.3249;24.741 26.7838;25.495849999999997;91.5578;35.0879;35.2954;147.467;101.057;79.7903;80.9924;31.2818;17.3473;48.3681;11.8779;17.7951;18.8402;19.44;28.0829;16.2027;29.9853;36.8422;15.8079;22.6004;80.4167;108.327;74.8861;19.1079;31.3726;42.0237;118.773;35.9474;105.112;71.1126;31.3543;24.3993;41.2585;16.9658;33.4642 2 291234;170465 MKI67_9232;ACAA2_7955 64.09049999999999 64.09049999999999 20.234991914503013 39.63745 39.63745 5.615771345505431 90.4437 90.4437 11.778984761005358 49.7822;78.3988 35.6665;43.6084 82.1147;98.7727 0 Exp 2,11(0.28);Exp 4,6(0.15);Hill,6(0.15);Linear,9(0.23);Poly 2,6(0.15);Power,2(0.05) 2.3411246032477115 140.11690402030945 1.5239794254302979 50.888092041015625 7.729069022040909 1.970352590084076 25.305502101968912 42.9163143082875 17.808551302720744 28.917456645997206 38.96002030660945 61.214736103646985 UP 0.9487179487179487 0.05128205128205128 0.0 GO:0019439 5 aromatic compound catabolic process 57 68 5 4 4 5 3 3 93 65 2386 0.74732 0.47682 0.74139 4.41 286954;65030;25315 ugt2b1;ephx2;ephx1 UGT2B10_33303,UGT2B1_33224;EPHX2_33282;EPHX1_8567 17.66633333333333 12.54415 6.44145 14.482081282600001 16.450555903815214 14.219966830638139 12.056638333333334 7.348245 2.66377 12.434639598728157 11.03125842737302 12.186672674854623 30.40375 25.495849999999997 17.3473 16.08222994386973 29.00956480119513 15.849246581767998 12.54415;6.44145;34.0134 7.348245;2.66377;26.1579 25.495849999999997;17.3473;48.3681 4 0 3 286954;65030;25315 UGT2B10_33303,UGT2B1_33224;EPHX2_33282;EPHX1_8567 17.66633333333333 12.54415 14.482081282600001 12.056638333333334 7.348245 12.434639598728157 30.40375 25.495849999999997 16.08222994386973 12.54415;6.44145;34.0134 7.348245;2.66377;26.1579 25.495849999999997;17.3473;48.3681 0 0 Exp 4,2(0.5);Linear,1(0.25);Poly 2,1(0.25) 1.914418304155267 7.7392884492874146 1.635288953781128 2.3739430904388428 0.3310827690683977 1.865028202533722 1.278315620540436 34.05435104612623 -2.0144810050859636 26.127757671752633 12.204993616965211 48.60250638303478 UP 1.0 0.0 0.0 GO:0046483 4 heterocycle metabolic process 413 462 32 31 29 32 28 28 68 434 2017 0.99769 0.0047869 0.0065935 6.06 360243;360268;64305;78968;24950;298490;313245;296371;680308;291234;316273;293502;63868;364975;65030;25315;114027;25086;24894;362485;65155;26760;24763;681337;314304;192272;50559;170465 top2a;sult1e1;sult1b1;srebf1;srd5a1;ppcs;polr1e;pltp;mthfd2;mki67;mcm3;kif22;hspd1;gcdh;ephx2;ephx1;dao;cyp2e1;cyp2a1;ccne2;alas1;akr7a3;acsm3;acot4;acot3;acot2;acot1;acaa2 TOP2A_10059;SULT1E1_32446;SULT1B1_32942;SREBF1_32750;SRD5A1_32503;PPCS_9540;POLR1E_9523;PLTP_32412;MTHFD2_9261;MKI67_9232;MCM3_9207;KIF22_8963;HSPD1_8849;GCDH_8693;EPHX2_33282;EPHX1_8567;DAO_8437;CYP2E1_8421;CYP2A1_32717;CCNE2_8227;ALAS1_8018;AKR7A3_8015;ACSM3_7976;ACOT4_7971;ACOT3_7970;ACOT2_7969;ACOT1_7968;ACAA2_7955 38.04958071428571 32.4486 6.1336 25.223411797746323 38.212194967362876 25.445605094884304 25.516100357142857 24.714199999999998 2.43617 16.939397644950414 25.289636608999828 17.01722240209519 69.34146071428572 48.4269 15.8079 55.78159799777555 68.36694272575988 51.388957199403286 22.5 66.5952 54.9577;59.2729;15.4629;41.2009;29.2087;15.1091;73.982;87.0256;57.4184;49.7822;54.0045;73.9175;34.4455;15.9021;6.44145;34.0134;6.1336;7.89174;9.37187;77.8893;27.1843;18.819;52.2057;12.3157;30.8838;13.6362;28.5134;78.3988 18.8326;45.3114;7.69418;31.4864;22.9308;7.94061;47.589;56.6266;46.387;35.6665;33.259;47.5608;26.6907;10.4227;2.66377;26.1579;2.43617;4.16797;4.95906;49.2672;21.5215;11.5469;42.2655;6.70485;24.6874;11.3249;24.741;43.6084 218.525;91.5578;35.0879;60.0774;39.9852;30.6311;165.722;104.563;79.7903;82.1147;111.753;165.416;48.4857;31.2818;17.3473;48.3681;16.2027;15.8079;19.1079;185.461;36.6615;51.6405;71.1126;24.3993;41.2585;16.9658;33.4642;98.7727 21 7 21 360268;64305;78968;298490;313245;296371;680308;63868;364975;65030;25315;114027;25086;24894;65155;26760;24763;681337;314304;192272;50559 SULT1E1_32446;SULT1B1_32942;SREBF1_32750;PPCS_9540;POLR1E_9523;PLTP_32412;MTHFD2_9261;HSPD1_8849;GCDH_8693;EPHX2_33282;EPHX1_8567;DAO_8437;CYP2E1_8421;CYP2A1_32717;ALAS1_8018;AKR7A3_8015;ACSM3_7976;ACOT4_7971;ACOT3_7970;ACOT2_7969;ACOT1_7968 30.82045523809524 27.1843 23.2620488965664 22.063119523809526 21.5215 17.183321425794393 49.501585714285724 36.6615 36.801583999554765 59.2729;15.4629;41.2009;15.1091;73.982;87.0256;57.4184;34.4455;15.9021;6.44145;34.0134;6.1336;7.89174;9.37187;27.1843;18.819;52.2057;12.3157;30.8838;13.6362;28.5134 45.3114;7.69418;31.4864;7.94061;47.589;56.6266;46.387;26.6907;10.4227;2.66377;26.1579;2.43617;4.16797;4.95906;21.5215;11.5469;42.2655;6.70485;24.6874;11.3249;24.741 91.5578;35.0879;60.0774;30.6311;165.722;104.563;79.7903;48.4857;31.2818;17.3473;48.3681;16.2027;15.8079;19.1079;36.6615;51.6405;71.1126;24.3993;41.2585;16.9658;33.4642 7 360243;24950;291234;316273;293502;362485;170465 TOP2A_10059;SRD5A1_32503;MKI67_9232;MCM3_9207;KIF22_8963;CCNE2_8227;ACAA2_7955 59.73695714285714 54.9577 18.09987920510862 35.87504285714286 35.6665 11.836363867880072 128.8610857142857 111.753 63.06289819321738 54.9577;29.2087;49.7822;54.0045;73.9175;77.8893;78.3988 18.8326;22.9308;35.6665;33.259;47.5608;49.2672;43.6084 218.525;39.9852;82.1147;111.753;165.416;185.461;98.7727 0 Exp 2,9(0.33);Exp 4,4(0.15);Hill,3(0.11);Linear,8(0.29);Poly 2,4(0.15) 2.1984988423232963 105.62708520889282 1.5084086656570435 50.888092041015625 9.254728205907108 1.8705788850784302 28.706698237608396 47.39246319096303 19.241659663254776 31.79054105103094 48.67966766926075 90.00325375931068 UP 0.75 0.25 0.0 GO:0048856 3 anatomical structure development 699 756 29 29 19 28 19 19 77 737 1714 0.017637 0.99067 0.030501 2.51 360243;78968;24950;25664;54133;24614;338475;291234;25685;58868;25315;50549;24303;25413;114494;25612;25649;65155;81633 top2a;srebf1;srd5a1;pparg;pdlim1;orm1;nrep;mki67;igfbp1;fzd1;ephx1;cyp4a1;cyp2d3;cpt2;ccna2;asns;apoa2;alas1;acta2 TOP2A_10059;SREBF1_32750;SRD5A1_32503;PPARG_32510;PDLIM1_9452;ORM1_9400;NREP_9364;MKI67_9232;IGFBP1_32306;FZD1_8671;EPHX1_8567;CYP4A1_33111;CYP2D3_8420;CPT2_8374;CCNA2_8221;ASNS_8091;APOA2_33095;ALAS1_8018;ACTA2_33040 25664(0.0441) 43.343862105263156 34.0134 3.54778 25.416328625737954 42.529270302782805 24.10263101863763 29.81383894736842 24.8356 1.51564 17.009568390054234 29.688896763211886 17.048476130636487 90.62117631578947 60.0774 8.55785 84.09787900807468 82.0796236305054 64.82991066210062 54.9577;41.2009;29.2087;60.1903;67.1147;24.2519;69.4104;49.7822;98.8371;25.231;34.0134;23.208;12.8059;31.2175;52.8265;28.1893;3.54778;27.1843;90.3558 18.8326;31.4864;22.9308;43.9036;47.2419;19.7133;43.1468;35.6665;57.328;13.6792;26.1579;18.863;8.8664;24.8356;37.3288;23.1774;1.51564;21.5215;70.2676 218.525;60.0774;39.9852;101.057;123.914;31.358;157.944;82.1147;357.409;131.659;48.3681;29.9853;22.6004;42.0237;90.0448;35.9474;8.55785;36.6615;103.57 13 6 13 78968;25664;54133;24614;25685;58868;25315;50549;24303;25413;25612;25649;65155 SREBF1_32750;PPARG_32510;PDLIM1_9452;ORM1_9400;IGFBP1_32306;FZD1_8671;EPHX1_8567;CYP4A1_33111;CYP2D3_8420;CPT2_8374;ASNS_8091;APOA2_33095;ALAS1_8018 36.691698461538465 28.1893 25.326049966119157 26.022295384615386 23.1774 15.673771404045581 79.20143461538461 42.0237 92.15598410493435 41.2009;60.1903;67.1147;24.2519;98.8371;25.231;34.0134;23.208;12.8059;31.2175;28.1893;3.54778;27.1843 31.4864;43.9036;47.2419;19.7133;57.328;13.6792;26.1579;18.863;8.8664;24.8356;23.1774;1.51564;21.5215 60.0774;101.057;123.914;31.358;357.409;131.659;48.3681;29.9853;22.6004;42.0237;35.9474;8.55785;36.6615 6 360243;24950;338475;291234;114494;81633 TOP2A_10059;SRD5A1_32503;NREP_9364;MKI67_9232;CCNA2_8221;ACTA2_33040 57.75688333333333 53.8921 20.53890100072706 38.028850000000006 36.49765 18.264984583377 115.36394999999999 96.8074 63.281732096324625 54.9577;29.2087;69.4104;49.7822;52.8265;90.3558 18.8326;22.9308;43.1468;35.6665;37.3288;70.2676 218.525;39.9852;157.944;82.1147;90.0448;103.57 0 Exp 2,9(0.48);Hill,1(0.06);Linear,6(0.32);Poly 2,3(0.16) 1.9819434098233424 38.72514796257019 1.5124053955078125 3.5849626064300537 0.5475169283068985 1.912555456161499 31.915286964683844 54.77243724584247 22.165404221917854 37.462273672818995 52.806158121782964 128.436194509796 UP 0.6842105263157895 0.3157894736842105 0.0 GO:0034312 7 diol biosynthetic process 6 8 1 1 1 1 1 1 95 7 2444 0.96606 0.26493 0.26493 12.5 25315 ephx1 EPHX1_8567 34.0134 34.0134 34.0134 34.0134 26.1579 26.1579 26.1579 26.1579 48.3681 48.3681 48.3681 48.3681 0.0 34.0134 0.0 34.0134 34.0134 26.1579 48.3681 1 0 1 25315 EPHX1_8567 34.0134 34.0134 26.1579 26.1579 48.3681 48.3681 34.0134 26.1579 48.3681 0 0 Linear,1(1) 2.000227451324463 2.000227451324463 2.000227451324463 2.000227451324463 0.0 2.000227451324463 34.0134 34.0134 26.1579 26.1579 48.3681 48.3681 UP 1.0 0.0 0.0 GO:0002526 6 acute inflammatory response 39 43 4 4 3 4 3 3 93 40 2411 0.92372 0.21912 0.21912 6.98 29142;24614;25649 vnn1;orm1;apoa2 VNN1_10157;ORM1_9400;APOA2_33095 16.177493333333334 20.7328 3.54778 11.078278763604628 16.029095391185933 11.872182685598116 12.68618 16.8296 1.51564 9.780830963737179 12.515957113146818 10.453125735567474 22.233216666666667 26.7838 8.55785 12.062029949839834 22.20260408207477 13.017898839672219 1.5 22.492350000000002 20.7328;24.2519;3.54778 16.8296;19.7133;1.51564 26.7838;31.358;8.55785 3 0 3 29142;24614;25649 VNN1_10157;ORM1_9400;APOA2_33095 16.177493333333334 20.7328 11.078278763604628 12.68618 16.8296 9.780830963737179 22.233216666666667 26.7838 12.062029949839834 20.7328;24.2519;3.54778 16.8296;19.7133;1.51564 26.7838;31.358;8.55785 0 0 Exp 2,1(0.34);Hill,1(0.34);Linear,1(0.34) 3.055270654165076 9.919720768928528 1.7262524366378784 4.608505725860596 1.4611541121009808 3.5849626064300537 3.6412407697366316 28.713745896930035 1.6181278359686981 23.7542321640313 8.58374483918048 35.88268849415286 UP 1.0 0.0 0.0 GO:0016567 9 protein ubiquitination 75 76 3 3 3 3 3 3 93 73 2378 0.67878 0.55267 0.76263 3.95 365813;297594;64515 trim59;cdca3;cdc20 TRIM59_10085;CDCA3_8260;CDC20_8255 68.14043333333333 56.1278 46.7245 29.329291071611888 68.41775610772685 28.08158738779047 35.4297 33.6269 21.1123 15.298674430158979 36.45456975312601 13.967157612540595 234.17966666666666 127.486 121.883 189.67188239782237 228.49171285668484 187.88604201798202 56.1278;46.7245;101.569 33.6269;21.1123;51.5499 121.883;127.486;453.17 0 3 0 3 365813;297594;64515 TRIM59_10085;CDCA3_8260;CDC20_8255 68.14043333333333 56.1278 29.329291071611888 35.4297 33.6269 15.298674430158979 234.17966666666666 127.486 189.67188239782237 56.1278;46.7245;101.569 33.6269;21.1123;51.5499 121.883;127.486;453.17 0 Exp 2,3(1) 1.752946625078822 5.361966013908386 1.528815746307373 2.3038084506988525 0.44729046034142605 1.5293418169021606 34.95121610647474 101.32965056019194 18.117620151026408 52.741779848973586 19.54572644089859 448.81360689243473 DOWN 0.0 1.0 0.0 GO:0007165 4 signal transduction 714 752 23 23 15 22 15 15 81 737 1714 0.0010364 0.99958 0.0019186 1.99 78968;25664;65035;259241;315994;25626;25685;63868;24471;29455;58868;25599;114494;502970;114628 srebf1;pparg;nr1i3;nr1d2;mapkapk3;krt8;igfbp1;hspd1;hspb1;gdf15;fzd1;cd74;ccna2;angptl3;abcg5 SREBF1_32750;PPARG_32510;NR1I3_32602;NR1D2_9358;MAPKAPK3_9194;KRT8_8978;IGFBP1_32306;HSPD1_8849;HSPB1_8847;GDF15_33113;FZD1_8671;CD74_8252;CCNA2_8221;ANGPTL3_8045;ABCG5_7947 25664(0.0441) 57.072853333333335 52.8265 21.3654 29.77905380574615 56.93958253453362 27.192890488412868 36.15776 37.3288 12.9529 15.472840287964493 37.01489826597146 14.684200160584028 125.99907333333334 101.057 26.3528 115.6179683305662 119.76437753164906 106.1480986715729 41.2009;60.1903;22.095;99.0234;104.193;68.9539;98.8371;34.4455;41.6322;21.3654;25.231;94.9138;52.8265;58.0729;33.1119 31.4864;43.9036;12.9529;42.5557;59.1667;45.3374;57.328;26.6907;30.9494;17.8875;13.6792;58.8146;37.3288;40.0757;24.2098 60.0774;101.057;55.8619;102.838;434.985;143.578;357.409;48.4857;63.3196;26.3528;131.659;118.773;90.0448;105.112;50.4329 12 3 12 78968;25664;65035;259241;25626;25685;63868;24471;29455;58868;25599;502970 SREBF1_32750;PPARG_32510;NR1I3_32602;NR1D2_9358;KRT8_8978;IGFBP1_32306;HSPD1_8849;HSPB1_8847;GDF15_33113;FZD1_8671;CD74_8252;ANGPTL3_8045 55.49678333333333 49.852549999999994 29.50009808152673 35.138425 35.78105 15.567209369821677 109.54361666666667 101.94749999999999 86.03411615162095 41.2009;60.1903;22.095;99.0234;68.9539;98.8371;34.4455;41.6322;21.3654;25.231;94.9138;58.0729 31.4864;43.9036;12.9529;42.5557;45.3374;57.328;26.6907;30.9494;17.8875;13.6792;58.8146;40.0757 60.0774;101.057;55.8619;102.838;143.578;357.409;48.4857;63.3196;26.3528;131.659;118.773;105.112 3 315994;114494;114628 MAPKAPK3_9194;CCNA2_8221;ABCG5_7947 63.377133333333326 52.8265 36.696288533083745 40.235099999999996 37.3288 17.658741437882828 191.82090000000002 90.0448 211.51562661422915 104.193;52.8265;33.1119 59.1667;37.3288;24.2098 434.985;90.0448;50.4329 0 Exp 2,5(0.34);Linear,6(0.4);Poly 2,3(0.2);Power,1(0.07) 1.9792008481617196 31.4508935213089 1.5124053955078125 5.015069484710693 0.8951789731423547 1.8468482494354248 42.002572817818674 72.14313384884801 28.327422440168352 43.98809755983165 67.48830846009506 184.50983820657157 UP 0.8 0.2 0.0 GO:0050896 2 response to stimulus 1203 1308 59 57 45 56 42 42 54 1266 1185 0.078414 0.94786 0.14506 3.21 29142;286954;365813;360243;78968;24950;84386;83500;309607;24679;25664;54133;24614;338475;291234;24552;316273;315994;25211;25626;293502;24484;63868;24471;58868;65030;25315;65210;25086;25413;25599;114494;25612;25649;155423;502970;65155;81633;192272;170465;114628;140668 vnn1;ugt2b1;trim59;top2a;srebf1;srd5a1;slpi;slc22a8;rt1-ce5;prkar2b;pparg;pdlim1;orm1;nrep;mki67;me1;mcm3;mapkapk3;lyz2;krt8;kif22;igfbp3;hspd1;hspb1;fzd1;ephx2;ephx1;cyp2j4;cyp2e1;cpt2;cd74;ccna2;asns;apoa2;anxa7;angptl3;alas1;acta2;acot2;acaa2;abcg5;abcc3 VNN1_10157;UGT2B10_33303,UGT2B1_33224;TRIM59_10085;TOP2A_10059;SREBF1_32750;SRD5A1_32503;SLPI_9890;SLC22A8_9848;RT1-CE5_32445;PRKAR2B_33052;PPARG_32510;PDLIM1_9452;ORM1_9400;NREP_9364;MKI67_9232;ME1_9215;MCM3_9207;MAPKAPK3_9194;LYZ2_32611;KRT8_8978;KIF22_8963;IGFBP3_8881;HSPD1_8849;HSPB1_8847;FZD1_8671;EPHX2_33282;EPHX1_8567;CYP2J4_32580;CYP2E1_8421;CPT2_8374;CD74_8252;CCNA2_8221;ASNS_8091;APOA2_33095;ANXA7_8051;ANGPTL3_8045;ALAS1_8018;ACTA2_33040;ACOT2_7969;ACAA2_7955;ABCG5_7947;ABCC3_7941 25664(0.0441) 47.89206476190476 50.3641 3.54778 26.27780152193976 49.313188831889825 25.649159029265913 31.60039345238095 32.3727 1.51564 16.308027324088297 32.53127482681683 16.07163913015034 93.30809761904763 87.11189999999999 8.55785 74.46106140214016 96.85211341576024 75.49696781072886 20.7328;12.54415;56.1278;54.9577;41.2009;29.2087;53.7429;52.4905;54.8206;108.746;60.1903;67.1147;24.2519;69.4104;49.7822;49.3339;54.0045;104.193;77.8257;68.9539;73.9175;50.946;34.4455;41.6322;25.231;6.44145;34.0134;16.3155;7.89174;31.2175;94.9138;52.8265;28.1893;3.54778;64.7676;58.0729;27.1843;90.3558;13.6362;78.3988;33.1119;34.7775 16.8296;7.348245;33.6269;18.8326;31.4864;22.9308;37.8192;37.1479;26.5902;59.3814;43.9036;47.2419;19.7133;43.1468;35.6665;35.4173;33.259;59.1667;49.2403;45.3374;47.5608;36.3081;26.6907;30.9494;13.6792;2.66377;26.1579;8.2378;4.16797;24.8356;58.8146;37.3288;23.1774;1.51564;43.3787;40.0757;21.5215;70.2676;11.3249;43.6084;24.2098;26.6562 26.7838;25.495849999999997;121.883;218.525;60.0774;39.9852;92.543;89.1422;147.824;147.467;101.057;123.914;31.358;157.944;82.1147;80.9924;111.753;434.985;185.119;143.578;165.416;85.0816;48.4857;63.3196;131.659;17.3473;48.3681;36.8422;15.8079;42.0237;118.773;90.0448;35.9474;8.55785;127.439;105.112;36.6615;103.57;16.9658;98.7727;50.4329;49.7705 27 16 26 29142;286954;78968;83500;24679;25664;54133;24614;24552;25626;63868;24471;58868;65030;25315;65210;25086;25413;25599;25612;25649;155423;502970;65155;192272;140668 VNN1_10157;UGT2B10_33303,UGT2B1_33224;SREBF1_32750;SLC22A8_9848;PRKAR2B_33052;PPARG_32510;PDLIM1_9452;ORM1_9400;ME1_9215;KRT8_8978;HSPD1_8849;HSPB1_8847;FZD1_8671;EPHX2_33282;EPHX1_8567;CYP2J4_32580;CYP2E1_8421;CPT2_8374;CD74_8252;ASNS_8091;APOA2_33095;ANXA7_8051;ANGPTL3_8045;ALAS1_8018;ACOT2_7969;ABCC3_7941 39.532181538461536 34.22945 26.617460525815858 27.217462499999996 26.407049999999998 16.57848018029622 66.65177692307694 49.1281 44.483351496010776 20.7328;12.54415;41.2009;52.4905;108.746;60.1903;67.1147;24.2519;49.3339;68.9539;34.4455;41.6322;25.231;6.44145;34.0134;16.3155;7.89174;31.2175;94.9138;28.1893;3.54778;64.7676;58.0729;27.1843;13.6362;34.7775 16.8296;7.348245;31.4864;37.1479;59.3814;43.9036;47.2419;19.7133;35.4173;45.3374;26.6907;30.9494;13.6792;2.66377;26.1579;8.2378;4.16797;24.8356;58.8146;23.1774;1.51564;43.3787;40.0757;21.5215;11.3249;26.6562 26.7838;25.495849999999997;60.0774;89.1422;147.467;101.057;123.914;31.358;80.9924;143.578;48.4857;63.3196;131.659;17.3473;48.3681;36.8422;15.8079;42.0237;118.773;35.9474;8.55785;127.439;105.112;36.6615;16.9658;49.7705 16 365813;360243;24950;84386;309607;338475;291234;316273;315994;25211;293502;24484;114494;81633;170465;114628 TRIM59_10085;TOP2A_10059;SRD5A1_32503;SLPI_9890;RT1-CE5_32445;NREP_9364;MKI67_9232;MCM3_9207;MAPKAPK3_9194;LYZ2_32611;KIF22_8963;IGFBP3_8881;CCNA2_8221;ACTA2_33040;ACAA2_7955;ABCG5_7947 61.47687500000001 54.88915 19.71357383846637 38.72265625000001 36.81845 13.470420981591158 136.62461875 107.66149999999999 92.86461147179243 56.1278;54.9577;29.2087;53.7429;54.8206;69.4104;49.7822;54.0045;104.193;77.8257;73.9175;50.946;52.8265;90.3558;78.3988;33.1119 33.6269;18.8326;22.9308;37.8192;26.5902;43.1468;35.6665;33.259;59.1667;49.2403;47.5608;36.3081;37.3288;70.2676;43.6084;24.2098 121.883;218.525;39.9852;92.543;147.824;157.944;82.1147;111.753;434.985;185.119;165.416;85.0816;90.0448;103.57;98.7727;50.4329 0 Exp 2,13(0.31);Exp 4,4(0.1);Hill,1(0.03);Linear,19(0.45);Poly 2,5(0.12);Power,1(0.03) 1.924976892553137 86.32887494564056 1.5124053955078125 4.608505725860596 0.7076940299165064 1.7436412572860718 39.94474926513521 55.83938025867432 26.668282287515865 36.53250461724607 70.78849883552446 115.8276964025708 UP 0.6190476190476191 0.38095238095238093 0.0 GO:0032501 2 multicellular organismal process 609 640 23 22 17 23 16 16 80 624 1827 0.029966 0.98399 0.054774 2.5 360268;117267;24679;298490;25664;296371;259241;24484;63868;24471;65030;65210;25413;25649;81633;114628 sult1e1;slc26a2;prkar2b;ppcs;pparg;pltp;nr1d2;igfbp3;hspd1;hspb1;ephx2;cyp2j4;cpt2;apoa2;acta2;abcg5 SULT1E1_32446;SLC26A2_33072;PRKAR2B_33052;PPCS_9540;PPARG_32510;PLTP_32412;NR1D2_9358;IGFBP3_8881;HSPD1_8849;HSPB1_8847;EPHX2_33282;CYP2J4_32580;CPT2_8374;APOA2_33095;ACTA2_33040;ABCG5_7947 25664(0.0441) 49.507883125 46.2891 3.54778 33.08611694234944 46.53929776307168 30.482579357798276 32.48425125 33.628750000000004 1.51564 20.624873134970752 31.51748811558118 20.290650448802428 70.569503125 74.2006 8.55785 38.785193476765805 68.66507545285928 36.564781876647125 59.2729;54.7452;108.746;15.1091;60.1903;87.0256;99.0234;50.946;34.4455;41.6322;6.44145;16.3155;31.2175;3.54778;90.3558;33.1119 45.3114;38.3503;59.3814;7.94061;43.9036;56.6266;42.5557;36.3081;26.6907;30.9494;2.66377;8.2378;24.8356;1.51564;70.2676;24.2098 91.5578;95.3373;147.467;30.6311;101.057;104.563;102.838;85.0816;48.4857;63.3196;17.3473;36.8422;42.0237;8.55785;103.57;50.4329 12 4 12 360268;24679;298490;25664;296371;259241;63868;24471;65030;65210;25413;25649 SULT1E1_32446;PRKAR2B_33052;PPCS_9540;PPARG_32510;PLTP_32412;NR1D2_9358;HSPD1_8849;HSPB1_8847;EPHX2_33282;CYP2J4_32580;CPT2_8374;APOA2_33095 46.91393583333333 38.03885 36.1471060332403 29.217685 28.820050000000002 20.68740302534569 66.2241875 55.90265 42.66063438104013 59.2729;108.746;15.1091;60.1903;87.0256;99.0234;34.4455;41.6322;6.44145;16.3155;31.2175;3.54778 45.3114;59.3814;7.94061;43.9036;56.6266;42.5557;26.6907;30.9494;2.66377;8.2378;24.8356;1.51564 91.5578;147.467;30.6311;101.057;104.563;102.838;48.4857;63.3196;17.3473;36.8422;42.0237;8.55785 4 117267;24484;81633;114628 SLC26A2_33072;IGFBP3_8881;ACTA2_33040;ABCG5_7947 57.28972499999999 52.8456 23.97672476929452 42.283950000000004 37.3292 19.671840712805697 83.60544999999999 90.20945 23.372467088792067 54.7452;50.946;90.3558;33.1119 38.3503;36.3081;70.2676;24.2098 95.3373;85.0816;103.57;50.4329 0 Exp 2,5(0.32);Exp 4,2(0.13);Hill,2(0.13);Linear,3(0.19);Poly 2,2(0.13);Power,2(0.13) 1.8959961569133423 31.04245090484619 1.5084086656570435 2.9455835819244385 0.4546298492143155 1.7924261689186096 33.295685823248775 65.72008042675122 22.378063413864332 42.59043908613567 51.56475832138477 89.57424792861525 UP 0.75 0.25 0.0 GO:0071407 6 cellular response to organic cyclic compound 197 209 10 10 9 10 9 9 87 200 2251 0.74071 0.38893 0.70284 4.31 286954;24950;25664;24614;24484;58868;25315;114494;65155 ugt2b1;srd5a1;pparg;orm1;igfbp3;fzd1;ephx1;ccna2;alas1 UGT2B10_33303,UGT2B1_33224;SRD5A1_32503;PPARG_32510;ORM1_9400;IGFBP3_8881;FZD1_8671;EPHX1_8567;CCNA2_8221;ALAS1_8018 25664(0.0441) 35.155138888888885 29.2087 12.54415 15.879277121609197 35.953618778299166 16.88757166640858 25.432382777777782 22.9308 7.348245 11.837189180826213 26.149123116407345 12.520315630774624 65.52345 48.3681 25.495849999999997 37.36537355393359 65.42136255454022 37.50519042132236 12.54415;29.2087;60.1903;24.2519;50.946;25.231;34.0134;52.8265;27.1843 7.348245;22.9308;43.9036;19.7133;36.3081;13.6792;26.1579;37.3288;21.5215 25.495849999999997;39.9852;101.057;31.358;85.0816;131.659;48.3681;90.0448;36.6615 7 3 6 286954;25664;24614;58868;25315;65155 UGT2B10_33303,UGT2B1_33224;PPARG_32510;ORM1_9400;FZD1_8671;EPHX1_8567;ALAS1_8018 30.569175 26.20765 16.08749025105376 22.0539575 20.6174 12.54117979505267 62.43324166666667 42.514799999999994 43.53401601284238 12.54415;60.1903;24.2519;25.231;34.0134;27.1843 7.348245;43.9036;19.7133;13.6792;26.1579;21.5215 25.495849999999997;101.057;31.358;131.659;48.3681;36.6615 3 24950;24484;114494 SRD5A1_32503;IGFBP3_8881;CCNA2_8221 44.32706666666667 50.946 13.126607637288968 32.189233333333334 36.3081 8.034263996367907 71.70386666666667 85.0816 27.581038774733106 29.2087;50.946;52.8265 22.9308;36.3081;37.3288 39.9852;85.0816;90.0448 0 Exp 2,2(0.2);Exp 4,1(0.1);Linear,5(0.5);Poly 2,2(0.2) 1.9192690636486736 19.84084129333496 1.5124053955078125 3.5849626064300537 0.6130787110266614 1.788633644580841 24.780677836104218 45.52959994167357 17.698752512971307 33.16601304258424 41.11140594476339 89.9354940552366 UP 0.6666666666666666 0.3333333333333333 0.0 GO:1903508 9 positive regulation of nucleic acid-templated transcription 309 333 12 12 10 12 10 10 86 323 2128 0.27055 0.82607 0.53695 3.0 360243;78968;25664;54133;65035;259241;58868;306575;25599;114494 top2a;srebf1;pparg;pdlim1;nr1i3;nr1d2;fzd1;ckap2;cd74;ccna2 TOP2A_10059;SREBF1_32750;PPARG_32510;PDLIM1_9452;NR1I3_32602;NR1D2_9358;FZD1_8671;CKAP2_8324;CD74_8252;CCNA2_8221 25664(0.0441) 58.17664 57.574 22.095 25.50146091946716 58.1069596276816 24.206629923816386 34.990899999999996 39.94225 12.9529 15.416410596864338 36.760440844616866 15.314650817382423 112.81871000000001 110.8055 55.8619 45.49588980430476 108.76828168923375 42.32403316669887 54.9577;41.2009;60.1903;67.1147;22.095;99.0234;25.231;64.2131;94.9138;52.8265 18.8326;31.4864;43.9036;47.2419;12.9529;42.5557;13.6792;43.1133;58.8146;37.3288 218.525;60.0774;101.057;123.914;55.8619;102.838;131.659;125.437;118.773;90.0448 7 3 7 78968;25664;54133;65035;259241;58868;25599 SREBF1_32750;PPARG_32510;PDLIM1_9452;NR1I3_32602;NR1D2_9358;FZD1_8671;CD74_8252 58.538442857142854 60.1903 31.02842742286806 35.804899999999996 42.5557 17.329278943260547 99.16861428571428 102.838 30.201865687207093 41.2009;60.1903;67.1147;22.095;99.0234;25.231;94.9138 31.4864;43.9036;47.2419;12.9529;42.5557;13.6792;58.8146 60.0774;101.057;123.914;55.8619;102.838;131.659;118.773 3 360243;306575;114494 TOP2A_10059;CKAP2_8324;CCNA2_8221 57.332433333333334 54.9577 6.0533613549278815 33.091566666666665 37.3288 12.68281151256825 144.66893333333334 125.437 66.36407833167979 54.9577;64.2131;52.8265 18.8326;43.1133;37.3288 218.525;125.437;90.0448 0 Exp 2,4(0.4);Linear,2(0.2);Poly 2,3(0.3);Power,1(0.1) 1.9373061299413399 19.80006206035614 1.5124053955078125 2.7270524501800537 0.4467328222935815 1.8593307733535767 42.370670767211564 73.98260923278845 25.43570971723235 44.54609028276764 84.62006535230347 141.01735464769652 UP 0.7 0.3 0.0 GO:0046223 6 aflatoxin catabolic process 2 3 1 1 1 1 1 1 95 2 2449 0.99588 0.10891 0.10891 33.33 26760 akr7a3 AKR7A3_8015 18.819 18.819 18.819 18.819 11.5469 11.5469 11.5469 11.5469 51.6405 51.6405 51.6405 51.6405 0.0 18.819 0.0 18.819 18.819 11.5469 51.6405 1 0 1 26760 AKR7A3_8015 18.819 18.819 11.5469 11.5469 51.6405 51.6405 18.819 11.5469 51.6405 0 0 Poly 2,1(1) 1.664124846458435 1.664124846458435 1.664124846458435 1.664124846458435 0.0 1.664124846458435 18.819 18.819 11.5469 11.5469 51.6405 51.6405 UP 1.0 0.0 0.0 GO:1901377 6 organic heteropentacyclic compound catabolic process 2 3 1 1 1 1 1 1 95 2 2449 0.99588 0.10891 0.10891 33.33 26760 akr7a3 AKR7A3_8015 18.819 18.819 18.819 18.819 11.5469 11.5469 11.5469 11.5469 51.6405 51.6405 51.6405 51.6405 0.0 18.819 0.0 18.819 18.819 11.5469 51.6405 1 0 1 26760 AKR7A3_8015 18.819 18.819 11.5469 11.5469 51.6405 51.6405 18.819 11.5469 51.6405 0 0 Poly 2,1(1) 1.664124846458435 1.664124846458435 1.664124846458435 1.664124846458435 0.0 1.664124846458435 18.819 18.819 11.5469 11.5469 51.6405 51.6405 UP 1.0 0.0 0.0 GO:0010921 7 regulation of phosphatase activity 30 35 2 2 2 2 2 2 94 33 2418 0.85695 0.38281 0.38281 5.71 361604;24484 sytl2;igfbp3 SYTL2_32351;IGFBP3_8881 58.97765 58.97765 50.946 11.358468358233884 60.407532256418975 11.177015563671603 40.3727 40.3727 36.3081 5.7482124456216495 41.09632458765516 5.656384112865889 110.46379999999999 110.46379999999999 85.0816 35.89585148286642 114.98261710593438 35.32241126545907 0.5 58.97765 67.0093;50.946 44.4373;36.3081 135.846;85.0816 0 2 0 2 361604;24484 SYTL2_32351;IGFBP3_8881 58.97765 58.97765 11.358468358233884 40.3727 40.3727 5.7482124456216495 110.46379999999999 110.46379999999999 35.89585148286642 67.0093;50.946 44.4373;36.3081 135.846;85.0816 0 Linear,2(1) 1.621157730835677 3.2501710653305054 1.512166976928711 1.7380040884017944 0.1596909529661996 1.6250855326652527 43.235616 74.719684 32.40608400000001 48.339316 60.714687999999995 160.212912 DOWN 0.0 1.0 0.0 GO:1901615 4 organic hydroxy compound metabolic process 134 145 16 15 12 16 11 11 85 134 2317 0.99279 0.018582 0.021804 7.59 360268;64305;78968;24950;296371;25315;114027;25427;25086;25649;502970 sult1e1;sult1b1;srebf1;srd5a1;pltp;ephx1;dao;cyp51;cyp2e1;apoa2;angptl3 SULT1E1_32446;SULT1B1_32942;SREBF1_32750;SRD5A1_32503;PLTP_32412;EPHX1_8567;DAO_8437;CYP51_8429;CYP2E1_8421;APOA2_33095;ANGPTL3_8045 37.9075109090909 34.0134 3.54778 28.912688766447673 40.27567698848565 27.213760562905634 26.045523636363637 26.1579 1.51564 20.008415705086833 28.069007486107196 19.263463006723917 63.33625909090909 48.3681 8.55785 49.97363809354296 63.91699179843215 40.29598441760642 6.5 49.6369 59.2729;15.4629;41.2009;29.2087;87.0256;34.0134;6.1336;75.1522;7.89174;3.54778;58.0729 45.3114;7.69418;31.4864;22.9308;56.6266;26.1579;2.43617;48.098;4.16797;1.51564;40.0757 91.5578;35.0879;60.0774;39.9852;104.563;48.3681;16.2027;171.379;15.8079;8.55785;105.112 9 2 9 360268;64305;78968;296371;25315;114027;25086;25649;502970 SULT1E1_32446;SULT1B1_32942;SREBF1_32750;PLTP_32412;EPHX1_8567;DAO_8437;CYP2E1_8421;APOA2_33095;ANGPTL3_8045 34.735746666666664 34.0134 29.167744909099508 23.94132888888889 26.1579 20.819177017110594 53.926072222222224 48.3681 38.662279205796246 59.2729;15.4629;41.2009;87.0256;34.0134;6.1336;7.89174;3.54778;58.0729 45.3114;7.69418;31.4864;56.6266;26.1579;2.43617;4.16797;1.51564;40.0757 91.5578;35.0879;60.0774;104.563;48.3681;16.2027;15.8079;8.55785;105.112 2 24950;25427 SRD5A1_32503;CYP51_8429 52.18044999999999 52.18044999999999 32.48696040144416 35.5144 35.5144 17.795897783478058 105.68209999999999 105.68209999999999 92.909446985869 29.2087;75.1522 22.9308;48.098 39.9852;171.379 0 Exp 2,2(0.19);Exp 4,2(0.19);Hill,2(0.19);Linear,4(0.37);Poly 2,1(0.1) 1.8222037701823781 20.42863094806671 1.5084086656570435 2.9455835819244385 0.4138962653365502 1.7262524366378784 20.821203725044036 54.99381809313778 14.221305565024954 37.86974170770232 33.80372621345677 92.86879196836139 UP 0.8181818181818182 0.18181818181818182 0.0 GO:0019752 6 carboxylic acid metabolic process 287 320 42 42 37 42 37 37 59 283 2168 1.0 3.552E-11 3.552E-11 11.56 29142;286954;293820;24679;25664;680308;291234;24552;364975;65030;25315;171142;291075;29740;64526;117543;114027;50549;65210;25086;24303;499353;171521;29277;24894;311849;25413;25599;25612;502970;24763;50681;681337;314304;192272;50559;170465 vnn1;ugt2b1;psat1;prkar2b;pparg;mthfd2;mki67;me1;gcdh;ephx2;ephx1;ehhadh;eci2;eci1;ech1;decr1;dao;cyp4a1;cyp2j4;cyp2e1;cyp2d3;cyp2c24;cyp2c13;cyp2c11;cyp2a1;crat;cpt2;cd74;asns;angptl3;acsm3;acox1;acot4;acot3;acot2;acot1;acaa2 VNN1_10157;UGT2B10_33303,UGT2B1_33224;PSAT1_9583;PRKAR2B_33052;PPARG_32510;MTHFD2_9261;MKI67_9232;ME1_9215;GCDH_8693;EPHX2_33282;EPHX1_8567;EHHADH_8534;ECI2_8521;ECI1_8520;ECH1_8516;DECR1_8458;DAO_8437;CYP4A1_33111;CYP2J4_32580;CYP2E1_8421;CYP2D3_8420;CYP2C24_32875;CYP2C13_8419;CYP2C11_32593;CYP2A1_32717;CRAT_8375;CPT2_8374;CD74_8252;ASNS_8091;ANGPTL3_8045;ACSM3_7976;ACOX1_7973;ACOT4_7971;ACOT3_7970;ACOT2_7969;ACOT1_7968;ACAA2_7955 25664(0.0441) 33.9348545945946 23.8014 6.1336 28.347667136443963 37.57924782600842 30.25166376003023 23.193285810810814 19.0993 1.97988 17.61758376808764 25.034119842596738 18.59848894410227 49.371947297297304 33.4642 11.8779 35.66916839183375 54.96360226245252 37.3131218474905 15.0 20.7328 31.0 58.9435 20.7328;12.54415;26.3316;108.746;60.1903;57.4184;49.7822;49.3339;15.9021;6.44145;34.0134;7.29984;8.72912;11.7653;9.87438;21.6199;6.1336;23.208;16.3155;7.89174;12.8059;58.9435;104.635;54.426;9.37187;8.98517;31.2175;94.9138;28.1893;58.0729;52.2057;23.8014;12.3157;30.8838;13.6362;28.5134;78.3988 16.8296;7.348245;20.9188;59.3814;43.9036;46.387;35.6665;35.4173;10.4227;2.66377;26.1579;5.26587;5.10151;8.40998;6.59127;17.4928;2.43617;18.863;8.2378;4.16797;8.8664;48.1505;49.2461;43.9518;4.95906;1.97988;24.8356;58.8146;23.1774;40.0757;42.2655;19.0993;6.70485;24.6874;11.3249;24.741;43.6084 26.7838;25.495849999999997;35.2954;147.467;101.057;79.7903;82.1147;80.9924;31.2818;17.3473;48.3681;11.8779;17.7951;18.8402;19.44;28.0829;16.2027;29.9853;36.8422;15.8079;22.6004;80.4167;108.327;74.8861;19.1079;31.3726;42.0237;118.773;35.9474;105.112;71.1126;31.3543;24.3993;41.2585;16.9658;33.4642;98.7727 36 2 35 29142;286954;293820;24679;25664;680308;24552;364975;65030;25315;171142;291075;29740;64526;117543;114027;50549;65210;25086;24303;499353;171521;29277;24894;311849;25413;25599;25612;502970;24763;50681;681337;314304;192272;50559 VNN1_10157;UGT2B10_33303,UGT2B1_33224;PSAT1_9583;PRKAR2B_33052;PPARG_32510;MTHFD2_9261;ME1_9215;GCDH_8693;EPHX2_33282;EPHX1_8567;EHHADH_8534;ECI2_8521;ECI1_8520;ECH1_8516;DECR1_8458;DAO_8437;CYP4A1_33111;CYP2J4_32580;CYP2E1_8421;CYP2D3_8420;CYP2C24_32875;CYP2C13_8419;CYP2C11_32593;CYP2A1_32717;CRAT_8375;CPT2_8374;CD74_8252;ASNS_8091;ANGPTL3_8045;ACSM3_7976;ACOX1_7973;ACOT4_7971;ACOT3_7970;ACOT2_7969;ACOT1_7968 32.21167485714286 23.208 27.96906924104505 22.253619285714286 18.863 17.632182525569963 47.02499 31.3726 35.1873620084888 20.7328;12.54415;26.3316;108.746;60.1903;57.4184;49.3339;15.9021;6.44145;34.0134;7.29984;8.72912;11.7653;9.87438;21.6199;6.1336;23.208;16.3155;7.89174;12.8059;58.9435;104.635;54.426;9.37187;8.98517;31.2175;94.9138;28.1893;58.0729;52.2057;23.8014;12.3157;30.8838;13.6362;28.5134 16.8296;7.348245;20.9188;59.3814;43.9036;46.387;35.4173;10.4227;2.66377;26.1579;5.26587;5.10151;8.40998;6.59127;17.4928;2.43617;18.863;8.2378;4.16797;8.8664;48.1505;49.2461;43.9518;4.95906;1.97988;24.8356;58.8146;23.1774;40.0757;42.2655;19.0993;6.70485;24.6874;11.3249;24.741 26.7838;25.495849999999997;35.2954;147.467;101.057;79.7903;80.9924;31.2818;17.3473;48.3681;11.8779;17.7951;18.8402;19.44;28.0829;16.2027;29.9853;36.8422;15.8079;22.6004;80.4167;108.327;74.8861;19.1079;31.3726;42.0237;118.773;35.9474;105.112;71.1126;31.3543;24.3993;41.2585;16.9658;33.4642 2 291234;170465 MKI67_9232;ACAA2_7955 64.09049999999999 64.09049999999999 20.234991914503013 39.63745 39.63745 5.615771345505431 90.4437 90.4437 11.778984761005358 49.7822;78.3988 35.6665;43.6084 82.1147;98.7727 0 Exp 2,10(0.27);Exp 4,5(0.14);Hill,6(0.16);Linear,9(0.24);Poly 2,6(0.16);Power,2(0.06) 2.3496992133389853 135.55196011066437 1.5239794254302979 50.888092041015625 7.928372906391915 1.970352590084076 24.800612165981132 43.06909702320806 17.516512467538625 28.870059154082995 37.87855598047949 60.865338614115075 UP 0.9459459459459459 0.05405405405405406 0.0 GO:0044419 2 interspecies interaction between organisms 272 296 12 12 10 10 9 9 87 287 2164 0.30526 0.80319 0.62553 3.04 29142;365813;84386;25211;25626;63868;24471;25086;81633 vnn1;trim59;slpi;lyz2;krt8;hspd1;hspb1;cyp2e1;acta2 VNN1_10157;TRIM59_10085;SLPI_9890;LYZ2_32611;KRT8_8978;HSPD1_8849;HSPB1_8847;CYP2E1_8421;ACTA2_33040 50.189815555555555 53.7429 7.89174 26.8211263891019 55.161473411876585 24.141334435855477 34.99211888888888 33.6269 4.16797 19.136070857100247 37.76725909076501 17.031816834597503 89.01 92.543 15.8079 55.96045397923876 102.7795210869259 54.822326707079334 20.7328;56.1278;53.7429;77.8257;68.9539;34.4455;41.6322;7.89174;90.3558 16.8296;33.6269;37.8192;49.2403;45.3374;26.6907;30.9494;4.16797;70.2676 26.7838;121.883;92.543;185.119;143.578;48.4857;63.3196;15.8079;103.57 5 4 5 29142;25626;63868;24471;25086 VNN1_10157;KRT8_8978;HSPD1_8849;HSPB1_8847;CYP2E1_8421 34.731228 34.4455 23.10416865214848 24.795014000000002 26.6907 15.43034736639069 59.595000000000006 48.4857 50.45869214639833 20.7328;68.9539;34.4455;41.6322;7.89174 16.8296;45.3374;26.6907;30.9494;4.16797 26.7838;143.578;48.4857;63.3196;15.8079 4 365813;84386;25211;81633 TRIM59_10085;SLPI_9890;LYZ2_32611;ACTA2_33040 69.51304999999999 66.97675 17.61990282010663 47.7385 43.52975 16.404730182684087 125.77875 112.72649999999999 41.36941621032781 56.1278;53.7429;77.8257;90.3558 33.6269;37.8192;49.2403;70.2676 121.883;92.543;185.119;103.57 0 Exp 2,2(0.23);Exp 4,1(0.12);Linear,5(0.56);Poly 2,1(0.12) 1.8477925994656421 17.820682883262634 1.528815746307373 4.608505725860596 0.9911211689873669 1.6557694673538208 32.666679648008994 67.71295146310213 22.489885928916728 47.49435184886104 52.44917006689733 125.57082993310266 CONFLICT 0.5555555555555556 0.4444444444444444 0.0 GO:0045664 8 regulation of neuron differentiation 157 165 5 5 4 5 4 4 92 161 2290 0.24237 0.88053 0.52282 2.42 338475;24471;58868;64515 nrep;hspb1;fzd1;cdc20 NREP_9364;HSPB1_8847;FZD1_8671;CDC20_8255 59.46065 55.5213 25.231 33.474533769767916 60.147205433306155 31.740821349847838 34.831325 37.0481 13.6792 16.44323172035128 35.69192291949651 15.515811593296778 201.52315 144.80149999999998 63.3196 172.43984469709048 194.02638553835007 166.31470982760214 69.4104;41.6322;25.231;101.569 43.1468;30.9494;13.6792;51.5499 157.944;63.3196;131.659;453.17 2 2 2 24471;58868 HSPB1_8847;FZD1_8671 33.4316 33.4316 11.597399739596785 22.3143 22.3143 12.21187553244792 97.4893 97.4893 48.323253162219935 41.6322;25.231 30.9494;13.6792 63.3196;131.659 2 338475;64515 NREP_9364;CDC20_8255 85.4897 85.4897 22.739564133465684 47.348349999999996 47.348349999999996 5.941888992988682 305.557 305.557 208.75630658257967 69.4104;101.569 43.1468;51.5499 157.944;453.17 0 Exp 2,2(0.5);Linear,1(0.25);Poly 2,1(0.25) 1.7537320167204182 7.102959036827087 1.5124053955078125 2.2143635749816895 0.3304059130949029 1.6880950331687927 26.65560690562743 92.26569309437258 18.716957914055744 50.94569208594426 32.53210219685138 370.5141978031486 CONFLICT 0.5 0.5 0.0 GO:0010212 5 response to ionizing radiation 75 76 4 4 2 4 2 2 94 74 2377 0.44733 0.79004 1.0 2.63 360243;114628 top2a;abcg5 TOP2A_10059;ABCG5_7947 44.034800000000004 44.034800000000004 33.1119 15.447313320445058 40.89735334156506 14.796362585140674 21.5212 21.5212 18.8326 3.8022545837962927 22.293461861398367 3.642027341311286 134.47895 134.47895 50.4329 118.85906377388726 110.33792529711377 113.85033550145678 54.9577;33.1119 18.8326;24.2098 218.525;50.4329 0 2 0 2 360243;114628 TOP2A_10059;ABCG5_7947 44.034800000000004 44.034800000000004 15.447313320445058 21.5212 21.5212 3.8022545837962927 134.47895 134.47895 118.85906377388726 54.9577;33.1119 18.8326;24.2098 218.525;50.4329 0 Exp 2,2(1) 2.138463836840649 4.338087797164917 1.8061060905456543 2.5319817066192627 0.5132715704236114 2.1690438985824585 22.625916000000004 65.443684 16.251544 26.790856 -30.251307999999995 299.209208 DOWN 0.0 1.0 0.0 GO:0071229 5 cellular response to acid chemical 95 99 4 4 4 4 4 4 92 95 2356 0.68341 0.51822 0.78717 4.04 78968;25664;24614;24471 srebf1;pparg;orm1;hspb1 SREBF1_32750;PPARG_32510;ORM1_9400;HSPB1_8847 25664(0.0441) 41.818825 41.41655 24.2519 14.680197635221631 42.23386485448796 15.086657665955245 31.513175 31.2179 19.7133 9.883964131317272 31.835437452410144 10.155030188752276 63.953 61.698499999999996 31.358 28.60397590033012 64.71836085048719 29.457431008007447 41.2009;60.1903;24.2519;41.6322 31.4864;43.9036;19.7133;30.9494 60.0774;101.057;31.358;63.3196 4 0 4 78968;25664;24614;24471 SREBF1_32750;PPARG_32510;ORM1_9400;HSPB1_8847 41.818825 41.41655 14.680197635221631 31.513175 31.2179 9.883964131317272 63.953 61.698499999999996 28.60397590033012 41.2009;60.1903;24.2519;41.6322 31.4864;43.9036;19.7133;30.9494 60.0774;101.057;31.358;63.3196 0 0 Exp 2,3(0.75);Linear,1(0.25) 2.095932276534998 8.868345737457275 1.5239794254302979 3.5849626064300537 0.9275950945326812 1.879701852798462 27.43223131748281 56.2054186825172 21.826890151309062 41.199459848690935 35.92110361767648 91.98489638232353 UP 1.0 0.0 0.0 GO:0051047 6 positive regulation of secretion 140 149 5 5 5 5 5 5 91 144 2307 0.50413 0.67227 1.0 3.36 361604;309607;24614;63868;65210 sytl2;rt1-ce5;orm1;hspd1;cyp2j4 SYTL2_32351;RT1-CE5_32445;ORM1_9400;HSPD1_8849;CYP2J4_32580 39.36856 34.4455 16.3155 21.136281322597885 37.451344716112814 21.712786644590636 25.13386 26.5902 8.2378 13.153201008233701 23.88534980377763 13.764180506930552 80.07118 48.4857 31.358 56.878458858270754 75.99095779948614 56.36806904264355 67.0093;54.8206;24.2519;34.4455;16.3155 44.4373;26.5902;19.7133;26.6907;8.2378 135.846;147.824;31.358;48.4857;36.8422 3 2 3 24614;63868;65210 ORM1_9400;HSPD1_8849;CYP2J4_32580 25.0043 24.2519 9.088388433600315 18.213933333333333 19.7133 9.317373820091865 38.8953 36.8422 8.746481665789943 24.2519;34.4455;16.3155 19.7133;26.6907;8.2378 31.358;48.4857;36.8422 2 361604;309607 SYTL2_32351;RT1-CE5_32445 60.91495 60.91495 8.618712423848493 35.51375 35.51375 12.619805434514438 141.835 141.835 8.469725025052838 67.0093;54.8206 44.4373;26.5902 135.846;147.824 0 Exp 2,3(0.6);Exp 4,1(0.2);Linear,1(0.2) 2.002245780022722 10.5409175157547 1.512166976928711 3.5849626064300537 0.8421476352010333 1.8475407361984253 20.8417925630759 57.895327436924106 13.604570982157304 36.66314901784269 30.215012618692747 129.92734738130724 UP 0.6 0.4 0.0 GO:0031347 6 regulation of defense response 154 164 8 8 6 8 6 6 90 158 2293 0.57591 0.59259 1.0 3.66 84386;309607;25664;259241;63868;25599 slpi;rt1-ce5;pparg;nr1d2;hspd1;cd74 SLPI_9890;RT1-CE5_32445;PPARG_32510;NR1D2_9358;HSPD1_8849;CD74_8252 25664(0.0441) 66.18941666666667 57.505449999999996 34.4455 25.42043302175762 64.71688684210527 23.269654506077618 39.39566666666666 40.18745 26.5902 12.126694909276278 40.46697667352739 12.263350763803848 101.92011666666667 101.94749999999999 48.4857 32.66784615920777 102.76467001617172 30.50536353678425 53.7429;54.8206;60.1903;99.0234;34.4455;94.9138 37.8192;26.5902;43.9036;42.5557;26.6907;58.8146 92.543;147.824;101.057;102.838;48.4857;118.773 4 2 4 25664;259241;63868;25599 PPARG_32510;NR1D2_9358;HSPD1_8849;CD74_8252 72.14325 77.55205 30.5779538234657 42.99115 43.22965 13.128955553914668 92.78842499999999 101.94749999999999 30.590264630911037 60.1903;99.0234;34.4455;94.9138 43.9036;42.5557;26.6907;58.8146 101.057;102.838;48.4857;118.773 2 84386;309607 SLPI_9890;RT1-CE5_32445 54.28175 54.28175 0.7620489780842511 32.2047 32.2047 7.9401020459437515 120.18350000000001 120.18350000000001 39.08956997077355 53.7429;54.8206 37.8192;26.5902 92.543;147.824 0 Exp 2,3(0.5);Linear,1(0.17);Poly 2,1(0.17);Power,1(0.17) 1.8181659555892362 11.126111507415771 1.5239794254302979 2.7270524501800537 0.4401319976187658 1.685884714126587 45.84883395165863 86.52999938167468 29.692289833916504 49.09904349941684 75.78039566530589 128.05983766802746 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0002831 5 regulation of response to biotic stimulus 69 73 3 3 3 3 3 3 93 70 2381 0.70477 0.52495 0.75413 4.11 309607;25664;63868 rt1-ce5;pparg;hspd1 RT1-CE5_32445;PPARG_32510;HSPD1_8849 25664(0.0441) 49.8188 54.8206 34.4455 13.581685616667773 51.54186146515784 13.111186047336004 32.39483333333333 26.6907 26.5902 9.967010971366143 33.950091190192566 10.448824395046167 99.12223333333334 101.057 48.4857 49.69740388856676 100.94443794421282 46.11917323458867 54.8206;60.1903;34.4455 26.5902;43.9036;26.6907 147.824;101.057;48.4857 2 1 2 25664;63868 PPARG_32510;HSPD1_8849 47.3179 47.3179 18.204322660291428 35.29715 35.29715 12.171358313885893 74.77135 74.77135 37.173522725792346 60.1903;34.4455 43.9036;26.6907 101.057;48.4857 1 309607 RT1-CE5_32445 54.8206 54.8206 26.5902 26.5902 147.824 147.824 54.8206 26.5902 147.824 0 Exp 2,3(1) 1.6705430254247622 5.027289628982544 1.5239794254302979 1.8475407361984253 0.16270461811232353 1.6557694673538208 34.44967590020928 65.18792409979072 21.116098657358293 43.67356800930837 42.884326687677735 155.36013997898894 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0045824 7 negative regulation of innate immune response 16 19 2 2 2 2 2 2 94 17 2434 0.96756 0.15902 0.15902 10.53 309607;25664 rt1-ce5;pparg RT1-CE5_32445;PPARG_32510 25664(0.0441) 57.505449999999996 57.505449999999996 54.8206 3.7969512829375787 57.946727454458625 3.7453154021220443 35.2469 35.2469 26.5902 12.24242254539519 36.669700730026605 12.075934164497239 124.44050000000001 124.44050000000001 101.057 33.06926283575125 120.59722705874327 32.619543998928044 0.0 54.8206 0.5 57.505449999999996 54.8206;60.1903 26.5902;43.9036 147.824;101.057 1 1 1 25664 PPARG_32510 60.1903 60.1903 43.9036 43.9036 101.057 101.057 60.1903 43.9036 101.057 1 309607 RT1-CE5_32445 54.8206 54.8206 26.5902 26.5902 147.824 147.824 54.8206 26.5902 147.824 0 Exp 2,2(1) 1.677979162448314 3.371520161628723 1.5239794254302979 1.8475407361984253 0.22879239697375078 1.6857600808143616 52.243143999999994 62.767756 18.279768 52.21403199999999 78.60884000000001 170.27216 CONFLICT 0.5 0.5 0.0 GO:0010665 10 regulation of cardiac muscle cell apoptotic process 17 19 2 2 2 2 2 2 94 17 2434 0.96756 0.15902 0.15902 10.53 24484;50559 igfbp3;acot1 IGFBP3_8881;ACOT1_7968 39.7297 39.7297 28.5134 15.862243579645323 43.20705696476965 15.080674668566244 30.52455 30.52455 24.741 8.179174848662909 32.31760723577236 7.776168253290902 59.27289999999999 59.27289999999999 33.4642 36.499013567218526 67.27429642276422 34.70062394181911 0.0 28.5134 0.5 39.7297 50.946;28.5134 36.3081;24.741 85.0816;33.4642 1 1 1 50559 ACOT1_7968 28.5134 28.5134 24.741 24.741 33.4642 33.4642 28.5134 24.741 33.4642 1 24484 IGFBP3_8881 50.946 50.946 36.3081 36.3081 85.0816 85.0816 50.946 36.3081 85.0816 0 Exp 2,1(0.5);Linear,1(0.5) 9.404451712792829 52.62609612941742 1.7380040884017944 50.888092041015625 34.75436048720847 26.31304806470871 17.745752000000003 61.713648 19.188792 41.860308 8.687848000000002 109.85795199999998 CONFLICT 0.5 0.5 0.0 GO:0046340 8 diacylglycerol catabolic process 1 1 1 1 1 1 1 1 95 0 2451 1.0 0.037691 0.037691 100.0 25649 apoa2 APOA2_33095 3.54778 3.54778 3.54778 3.5477799999999995 1.51564 1.51564 1.51564 1.51564 8.55785 8.55785 8.55785 8.55785 0.0 3.54778 0.0 3.54778 3.54778 1.51564 8.55785 1 0 1 25649 APOA2_33095 3.54778 3.54778 1.51564 1.51564 8.55785 8.55785 3.54778 1.51564 8.55785 0 0 Hill,1(1) 1.7262524366378784 1.7262524366378784 1.7262524366378784 1.7262524366378784 0.0 1.7262524366378784 3.54778 3.54778 1.51564 1.51564 8.55785 8.55785 UP 1.0 0.0 0.0 GO:0120009 6 intermembrane lipid transfer 11 11 4 4 3 4 3 3 93 8 2443 0.99949 0.0068705 0.0068705 27.27 296371;25649;114628 pltp;apoa2;abcg5 PLTP_32412;APOA2_33095;ABCG5_7947 41.22842666666667 33.1119 3.54778 42.32664777461277 42.488439941080195 40.85386622634256 27.450680000000002 24.2098 1.51564 27.698049668003705 28.462493192424596 26.609033627883832 54.51791666666667 50.4329 8.55785 48.132761478080944 56.4131729039046 46.155630829647734 0.0 3.54778 0.5 18.32984 87.0256;3.54778;33.1119 56.6266;1.51564;24.2098 104.563;8.55785;50.4329 2 1 2 296371;25649 PLTP_32412;APOA2_33095 45.28669 45.28669 59.02773260066999 29.07112 29.07112 38.96933353370057 56.560425 56.560425 67.88589259383167 87.0256;3.54778 56.6266;1.51564 104.563;8.55785 1 114628 ABCG5_7947 33.1119 33.1119 24.2098 24.2098 50.4329 50.4329 33.1119 24.2098 50.4329 0 Exp 2,1(0.34);Hill,1(0.34);Poly 2,1(0.34) 1.875115234600086 5.766642808914185 1.5084086656570435 2.5319817066192627 0.5391903398065984 1.7262524366378784 -6.668684247004975 89.1255375803383 -3.8926138064251425 58.79397380642514 0.0505695860948947 108.98526374723843 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0030522 5 intracellular receptor signaling pathway 38 42 4 4 4 4 4 4 92 38 2413 0.9807 0.071158 0.071158 9.52 78968;25664;65035;259241 srebf1;pparg;nr1i3;nr1d2 SREBF1_32750;PPARG_32510;NR1I3_32602;NR1D2_9358 25664(0.0441) 55.627399999999994 50.6956 22.095 32.84599734325833 49.70415777065938 27.18615214325574 32.72465 37.02105 12.9529 14.307035895320883 32.15338412395623 13.999439163687692 79.958575 80.5672 55.8619 25.45926479199993 77.07617322919667 24.878340556748718 1.5 50.6956 41.2009;60.1903;22.095;99.0234 31.4864;43.9036;12.9529;42.5557 60.0774;101.057;55.8619;102.838 4 0 4 78968;25664;65035;259241 SREBF1_32750;PPARG_32510;NR1I3_32602;NR1D2_9358 55.627399999999994 50.6956 32.84599734325833 32.72465 37.02105 14.307035895320883 79.958575 80.5672 25.45926479199993 41.2009;60.1903;22.095;99.0234 31.4864;43.9036;12.9529;42.5557 60.0774;101.057;55.8619;102.838 0 0 Exp 2,2(0.5);Poly 2,1(0.25);Power,1(0.25) 2.0126966842279903 8.228143453598022 1.5239794254302979 2.7270524501800537 0.5013324030301451 1.9885557889938354 23.438322603606842 87.81647739639317 18.703754822585548 46.745545177414456 55.008495503840074 104.90865449615993 UP 1.0 0.0 0.0 GO:0019220 7 regulation of phosphate metabolic process 435 462 18 18 11 17 11 11 85 451 2000 0.049707 0.97446 0.10384 2.38 361604;24679;24484;24471;29455;299626;58868;25599;362485;114494;81633 sytl2;prkar2b;igfbp3;hspb1;gdf15;gadd45b;fzd1;cd74;ccne2;ccna2;acta2 SYTL2_32351;PRKAR2B_33052;IGFBP3_8881;HSPB1_8847;GDF15_33113;GADD45B_8679;FZD1_8671;CD74_8252;CCNE2_8227;CCNA2_8221;ACTA2_33040 62.1351909090909 52.8265 21.3654 28.395655243626805 64.50537354820028 25.661716539635904 41.41026363636364 37.3288 13.6792 17.383212444152715 43.2147394071554 16.19123357057982 106.99407272727272 103.57 26.3528 43.44565056152554 107.91842013789609 33.417468565004256 67.0093;108.746;50.946;41.6322;21.3654;52.5718;25.231;94.9138;77.8893;52.8265;90.3558 44.4373;59.3814;36.3081;30.9494;17.8875;37.1918;13.6792;58.8146;49.2672;37.3288;70.2676 135.846;147.467;85.0816;63.3196;26.3528;89.36;131.659;118.773;185.461;90.0448;103.57 6 5 6 24679;24471;29455;299626;58868;25599 PRKAR2B_33052;HSPB1_8847;GDF15_33113;GADD45B_8679;FZD1_8671;CD74_8252 57.41003333333333 47.102000000000004 36.46633596256508 36.31731666666666 34.0706 19.594904523412893 96.15523333333333 104.06649999999999 45.61077049705115 108.746;41.6322;21.3654;52.5718;25.231;94.9138 59.3814;30.9494;17.8875;37.1918;13.6792;58.8146 147.467;63.3196;26.3528;89.36;131.659;118.773 5 361604;24484;362485;114494;81633 SYTL2_32351;IGFBP3_8881;CCNE2_8227;CCNA2_8221;ACTA2_33040 67.80538 67.0093 16.729062796134148 47.5218 44.4373 13.780205874187837 120.00068000000002 103.57 41.601658020708754 67.0093;50.946;77.8893;52.8265;90.3558 44.4373;36.3081;49.2672;37.3288;70.2676 135.846;85.0816;185.461;90.0448;103.57 0 Exp 2,1(0.1);Linear,6(0.55);Poly 2,3(0.28);Power,1(0.1) 1.8576291955328077 21.9718359708786 1.512166976928711 5.015069484710693 1.0272836082712824 1.6208000183105469 45.35443101145273 78.91595080672907 31.137441552413545 51.68308572031373 81.31933395422472 132.66881150032071 CONFLICT 0.5454545454545454 0.45454545454545453 0.0 GO:0032354 6 response to follicle-stimulating hormone 20 22 2 2 2 2 2 2 94 20 2431 0.95245 0.20016 0.20016 9.09 24950;25612 srd5a1;asns SRD5A1_32503;ASNS_8091 28.698999999999998 28.698999999999998 28.1893 0.7208246527417437 28.75955913564399 0.7157187731086575 23.0541 23.0541 22.9308 0.17437253224164853 23.03945032092426 0.17313738419612298 37.966300000000004 37.966300000000004 35.9474 2.8551557610749065 38.20617215803737 2.8349315892270934 0.5 28.698999999999998 29.2087;28.1893 22.9308;23.1774 39.9852;35.9474 1 1 1 25612 ASNS_8091 28.1893 28.1893 23.1774 23.1774 35.9474 35.9474 28.1893 23.1774 35.9474 1 24950 SRD5A1_32503 29.2087 29.2087 22.9308 22.9308 39.9852 39.9852 29.2087 22.9308 39.9852 0 Exp 2,1(0.5);Linear,1(0.5) 2.5225158127923337 5.212258338928223 1.9512832164764404 3.2609751224517822 0.9260920279802984 2.6061291694641113 27.699987999999998 29.698012 22.812432 23.295767999999995 34.00925600000001 41.923344 CONFLICT 0.5 0.5 0.0 GO:0006108 8 malate metabolic process 2 2 1 1 1 1 1 1 95 1 2450 0.99859 0.073976 0.073976 50.0 24552 me1 ME1_9215 49.3339 49.3339 49.3339 49.33390000000001 35.4173 35.4173 35.4173 35.4173 80.9924 80.9924 80.9924 80.9924 0.0 49.3339 0.0 49.3339 49.3339 35.4173 80.9924 1 0 1 24552 ME1_9215 49.3339 49.3339 35.4173 35.4173 80.9924 80.9924 49.3339 35.4173 80.9924 0 0 Linear,1(1) 1.8166091442108154 1.8166091442108154 1.8166091442108154 1.8166091442108154 0.0 1.8166091442108154 49.3339 49.3339 35.4173 35.4173 80.9924 80.9924 UP 1.0 0.0 0.0 GO:0051239 4 regulation of multicellular organismal process 724 769 32 31 23 31 22 22 74 747 1704 0.0683 0.95796 0.14008 2.86 29142;361604;78968;309607;25664;24614;338475;259241;63868;24471;102551184;29455;58868;117543;25427;65210;25413;64515;25599;25649;502970;114628 vnn1;sytl2;srebf1;rt1-ce5;pparg;orm1;nrep;nr1d2;hspd1;hspb1;loc102551184;gdf15;fzd1;decr1;cyp51;cyp2j4;cpt2;cdc20;cd74;apoa2;angptl3;abcg5 VNN1_10157;SYTL2_32351;SREBF1_32750;RT1-CE5_32445;PPARG_32510;ORM1_9400;NREP_9364;NR1D2_9358;HSPD1_8849;HSPB1_8847;HIST1H4A_32934;GDF15_33113;FZD1_8671;DECR1_8458;CYP51_8429;CYP2J4_32580;CPT2_8374;CDC20_8255;CD74_8252;APOA2_33095;ANGPTL3_8045;ABCG5_7947 25664(0.0441) 47.87111272727273 41.41655 3.54778 28.131320546559436 47.11401327469271 27.176553006967815 30.586651818181814 28.820050000000002 1.51564 15.074732835874004 30.565428264932137 15.34181192251174 97.90094772727274 82.1883 8.55785 93.22567062111838 93.62862120745662 86.7212925204088 20.7328;67.0093;41.2009;54.8206;60.1903;24.2519;69.4104;99.0234;34.4455;41.6322;58.3303;21.3654;25.231;21.6199;75.1522;16.3155;31.2175;101.569;94.9138;3.54778;58.0729;33.1119 16.8296;44.4373;31.4864;26.5902;43.9036;19.7133;43.1468;42.5557;26.6907;30.9494;40.2068;17.8875;13.6792;17.4928;48.098;8.2378;24.8356;51.5499;58.8146;1.51564;40.0757;24.2098 26.7838;135.846;60.0774;147.824;101.057;31.358;157.944;102.838;48.4857;63.3196;105.902;26.3528;131.659;28.0829;171.379;36.8422;42.0237;453.17;118.773;8.55785;105.112;50.4329 15 7 15 29142;78968;25664;24614;259241;63868;24471;29455;58868;117543;65210;25413;25599;25649;502970 VNN1_10157;SREBF1_32750;PPARG_32510;ORM1_9400;NR1D2_9358;HSPD1_8849;HSPB1_8847;GDF15_33113;FZD1_8671;DECR1_8458;CYP2J4_32580;CPT2_8374;CD74_8252;APOA2_33095;ANGPTL3_8045 39.584052 31.2175 27.716947131890063 26.311169333333332 24.8356 15.243538983051838 62.08819666666667 48.4857 39.463889020282416 20.7328;41.2009;60.1903;24.2519;99.0234;34.4455;41.6322;21.3654;25.231;21.6199;16.3155;31.2175;94.9138;3.54778;58.0729 16.8296;31.4864;43.9036;19.7133;42.5557;26.6907;30.9494;17.8875;13.6792;17.4928;8.2378;24.8356;58.8146;1.51564;40.0757 26.7838;60.0774;101.057;31.358;102.838;48.4857;63.3196;26.3528;131.659;28.0829;36.8422;42.0237;118.773;8.55785;105.112 7 361604;309607;338475;102551184;25427;64515;114628 SYTL2_32351;RT1-CE5_32445;NREP_9364;HIST1H4A_32934;CYP51_8429;CDC20_8255;ABCG5_7947 65.62910000000001 67.0093 20.920617728610846 39.7484 43.1468 10.466793332089196 174.64255714285716 147.824 129.2573273342993 67.0093;54.8206;69.4104;58.3303;75.1522;101.569;33.1119 44.4373;26.5902;43.1468;40.2068;48.098;51.5499;24.2098 135.846;147.824;157.944;105.902;171.379;453.17;50.4329 0 Exp 2,10(0.46);Exp 4,1(0.05);Hill,1(0.05);Linear,7(0.32);Poly 2,2(0.1);Power,1(0.05) 2.0314301942913415 47.91974496841431 1.512166976928711 5.015069484710693 0.9845858548542742 1.847194492816925 36.11578204986341 59.62644340468205 24.287321892805377 36.88598174355826 58.94441939932964 136.85747605521578 UP 0.6818181818181818 0.3181818181818182 0.0 GO:0001819 6 positive regulation of cytokine production 132 142 7 7 7 7 7 7 89 135 2316 0.83696 0.28577 0.49128 4.93 309607;24614;63868;24471;65210;25599;25649 rt1-ce5;orm1;hspd1;hspb1;cyp2j4;cd74;apoa2 RT1-CE5_32445;ORM1_9400;HSPD1_8849;HSPB1_8847;CYP2J4_32580;CD74_8252;APOA2_33095 38.56104 34.4455 3.54778 29.977548425188697 39.07171704261481 31.38732363913926 24.64452 26.5902 1.51564 18.456077969857702 24.819819437732722 19.363855564559007 65.02290714285715 48.4857 8.55785 50.228237147963135 64.63370343090608 49.62629576411708 54.8206;24.2519;34.4455;41.6322;16.3155;94.9138;3.54778 26.5902;19.7133;26.6907;30.9494;8.2378;58.8146;1.51564 147.824;31.358;48.4857;63.3196;36.8422;118.773;8.55785 6 1 6 24614;63868;24471;65210;25599;25649 ORM1_9400;HSPD1_8849;HSPB1_8847;CYP2J4_32580;CD74_8252;APOA2_33095 35.85111333333333 29.3487 31.88568628987413 24.320240000000002 23.201999999999998 20.195763260664346 51.222725000000004 42.66395 37.78508621283997 24.2519;34.4455;41.6322;16.3155;94.9138;3.54778 19.7133;26.6907;30.9494;8.2378;58.8146;1.51564 31.358;48.4857;63.3196;36.8422;118.773;8.55785 1 309607 RT1-CE5_32445 54.8206 54.8206 26.5902 26.5902 147.824 147.824 54.8206 26.5902 147.824 0 Exp 2,3(0.43);Exp 4,1(0.15);Hill,1(0.15);Linear,1(0.15);Poly 2,1(0.15) 1.9633845724676635 14.259585499763489 1.6557694673538208 3.5849626064300537 0.6908087638250574 1.8468482494354248 16.353361346435324 60.76871865356466 10.972066103958833 38.31697389604117 27.81330834258489 102.23250594312941 UP 0.8571428571428571 0.14285714285714285 0.0 GO:0120162 5 positive regulation of cold-induced thermogenesis 37 42 4 4 2 4 2 2 94 40 2411 0.79085 0.47472 0.67123 4.76 117543;25413 decr1;cpt2 DECR1_8458;CPT2_8374 26.4187 26.4187 21.6199 6.786528043116018 24.73029882092852 6.352603072522323 21.1642 21.1642 17.4928 5.192143672896562 19.872461213461065 4.8601623156744305 35.0533 35.0533 28.0829 9.857634215165406 32.60084697453533 9.227345264797334 21.6199;31.2175 17.4928;24.8356 28.0829;42.0237 2 0 2 117543;25413 DECR1_8458;CPT2_8374 26.4187 26.4187 6.786528043116018 21.1642 21.1642 5.192143672896562 35.0533 35.0533 9.857634215165406 21.6199;31.2175 17.4928;24.8356 28.0829;42.0237 0 0 Exp 2,1(0.5);Linear,1(0.5) 1.8730489588728878 3.746105909347534 1.8691840171813965 1.8769218921661377 0.005471503873684263 1.873052954673767 17.013052000000002 35.824348 13.968256 28.360144000000002 21.391316000000003 48.715284 UP 1.0 0.0 0.0 GO:0097338 5 response to clozapine 1 2 1 1 1 1 1 1 95 1 2450 0.99859 0.073976 0.073976 50.0 24679 prkar2b PRKAR2B_33052 108.746 108.746 108.746 108.74600000000001 59.3814 59.3814 59.3814 59.3814 147.467 147.467 147.467 147.467 0.0 108.746 0.0 108.746 108.746 59.3814 147.467 1 0 1 24679 PRKAR2B_33052 108.746 108.746 59.3814 59.3814 147.467 147.467 108.746 59.3814 147.467 0 0 Power,1(1) 1.6208000183105469 1.6208000183105469 1.6208000183105469 1.6208000183105469 0.0 1.6208000183105469 108.746 108.746 59.3814 59.3814 147.467 147.467 UP 1.0 0.0 0.0 GO:0010468 6 regulation of gene expression 723 775 27 26 20 27 19 19 77 756 1695 0.011852 0.99393 0.023204 2.45 360243;78968;309607;25664;54133;24614;65035;259241;63868;24471;58868;65030;65210;306575;25599;114494;25649;155423;81633 top2a;srebf1;rt1-ce5;pparg;pdlim1;orm1;nr1i3;nr1d2;hspd1;hspb1;fzd1;ephx2;cyp2j4;ckap2;cd74;ccna2;apoa2;anxa7;acta2 TOP2A_10059;SREBF1_32750;RT1-CE5_32445;PPARG_32510;PDLIM1_9452;ORM1_9400;NR1I3_32602;NR1D2_9358;HSPD1_8849;HSPB1_8847;FZD1_8671;EPHX2_33282;CYP2J4_32580;CKAP2_8324;CD74_8252;CCNA2_8221;APOA2_33095;ANXA7_8051;ACTA2_33040 25664(0.0441) 48.33393315789474 52.8265 3.54778 28.385632860613768 46.57945672744993 28.09141441264679 30.521900526315783 30.9494 1.51564 18.77482595508101 30.137221785428675 18.99136760729209 90.15425 101.057 8.55785 52.37469756933366 85.25522414906202 50.703591856881864 54.9577;41.2009;54.8206;60.1903;67.1147;24.2519;22.095;99.0234;34.4455;41.6322;25.231;6.44145;16.3155;64.2131;94.9138;52.8265;3.54778;64.7676;90.3558 18.8326;31.4864;26.5902;43.9036;47.2419;19.7133;12.9529;42.5557;26.6907;30.9494;13.6792;2.66377;8.2378;43.1133;58.8146;37.3288;1.51564;43.3787;70.2676 218.525;60.0774;147.824;101.057;123.914;31.358;55.8619;102.838;48.4857;63.3196;131.659;17.3473;36.8422;125.437;118.773;90.0448;8.55785;127.439;103.57 14 5 14 78968;25664;54133;24614;65035;259241;63868;24471;58868;65030;65210;25599;25649;155423 SREBF1_32750;PPARG_32510;PDLIM1_9452;ORM1_9400;NR1I3_32602;NR1D2_9358;HSPD1_8849;HSPB1_8847;FZD1_8671;EPHX2_33282;CYP2J4_32580;CD74_8252;APOA2_33095;ANXA7_8051 42.94078785714286 37.8232 30.346804421351464 27.413114999999998 28.820050000000002 18.129648657288406 73.39499642857143 61.698499999999996 43.158053530707406 41.2009;60.1903;67.1147;24.2519;22.095;99.0234;34.4455;41.6322;25.231;6.44145;16.3155;94.9138;3.54778;64.7676 31.4864;43.9036;47.2419;19.7133;12.9529;42.5557;26.6907;30.9494;13.6792;2.66377;8.2378;58.8146;1.51564;43.3787 60.0774;101.057;123.914;31.358;55.8619;102.838;48.4857;63.3196;131.659;17.3473;36.8422;118.773;8.55785;127.439 5 360243;309607;306575;114494;81633 TOP2A_10059;RT1-CE5_32445;CKAP2_8324;CCNA2_8221;ACTA2_33040 63.43474 54.9577 15.683970214936013 39.2265 37.3288 19.734776434254343 137.08016 125.437 50.54579890780242 54.9577;54.8206;64.2131;52.8265;90.3558 18.8326;26.5902;43.1133;37.3288;70.2676 218.525;147.824;125.437;90.0448;103.57 0 Exp 2,7(0.37);Exp 4,2(0.11);Hill,1(0.06);Linear,4(0.22);Poly 2,4(0.22);Power,1(0.06) 1.9428222005420868 37.95033001899719 1.5124053955078125 3.5849626064300537 0.5289780209289389 1.8468482494354248 35.570196001462584 61.0976703143269 22.079709195752915 38.96409185687867 66.60371382892987 113.70478617107011 UP 0.7368421052631579 0.2631578947368421 0.0 GO:0051347 6 positive regulation of transferase activity 183 195 7 7 4 7 4 4 92 191 2260 0.12829 0.94513 0.24059 2.05 29455;299626;64515;25599 gdf15;gadd45b;cdc20;cd74 GDF15_33113;GADD45B_8679;CDC20_8255;CD74_8252 67.605 73.7428 21.3654 37.698017471479844 76.27867404513887 29.060506445312868 41.36095 44.370850000000004 17.8875 18.044660032356745 46.82534639322916 13.409151325348308 171.91395 104.06649999999999 26.3528 191.4263385556178 174.60576372395832 170.20797523913868 21.3654;52.5718;101.569;94.9138 17.8875;37.1918;51.5499;58.8146 26.3528;89.36;453.17;118.773 3 1 3 29455;299626;25599 GDF15_33113;GADD45B_8679;CD74_8252 56.28366666666667 52.5718 36.91443147677252 37.96463333333333 37.1918 20.47449223114783 78.16193333333332 89.36 47.216743479546885 21.3654;52.5718;94.9138 17.8875;37.1918;58.8146 26.3528;89.36;118.773 1 64515 CDC20_8255 101.569 101.569 51.5499 51.5499 453.17 453.17 101.569 51.5499 453.17 0 Exp 2,2(0.5);Linear,1(0.25);Poly 2,1(0.25) 2.107915198635153 9.754947662353516 1.5293418169021606 5.015069484710693 1.7184619673368515 1.6052681803703308 30.66094287794975 104.54905712205026 23.677183168290384 59.04471683170962 -15.683861784505439 359.5117617845054 UP 0.75 0.25 0.0 GO:0006335 8 DNA replication-dependent nucleosome assembly 3 4 1 1 1 1 1 1 95 3 2448 0.99197 0.14253 0.14253 25.0 102551184 loc102551184 HIST1H4A_32934 58.3303 58.3303 58.3303 58.33030000000001 40.2068 40.2068 40.2068 40.2068 105.902 105.902 105.902 105.902 0.0 58.3303 0.0 58.3303 58.3303 40.2068 105.902 0 1 0 1 102551184 HIST1H4A_32934 58.3303 58.3303 40.2068 40.2068 105.902 105.902 58.3303 40.2068 105.902 0 Linear,1(1) 1.6554155349731445 1.6554155349731445 1.6554155349731445 1.6554155349731445 0.0 1.6554155349731445 58.3303 58.3303 40.2068 40.2068 105.902 105.902 DOWN 0.0 1.0 0.0 GO:0006336 8 DNA replication-independent nucleosome assembly 4 4 1 1 1 1 1 1 95 3 2448 0.99197 0.14253 0.14253 25.0 102551184 loc102551184 HIST1H4A_32934 58.3303 58.3303 58.3303 58.33030000000001 40.2068 40.2068 40.2068 40.2068 105.902 105.902 105.902 105.902 0.0 58.3303 0.0 58.3303 58.3303 40.2068 105.902 0 1 0 1 102551184 HIST1H4A_32934 58.3303 58.3303 40.2068 40.2068 105.902 105.902 58.3303 40.2068 105.902 0 Linear,1(1) 1.6554155349731445 1.6554155349731445 1.6554155349731445 1.6554155349731445 0.0 1.6554155349731445 58.3303 58.3303 40.2068 40.2068 105.902 105.902 DOWN 0.0 1.0 0.0 GO:0045653 8 negative regulation of megakaryocyte differentiation 3 4 1 1 1 1 1 1 95 3 2448 0.99197 0.14253 0.14253 25.0 102551184 loc102551184 HIST1H4A_32934 58.3303 58.3303 58.3303 58.33030000000001 40.2068 40.2068 40.2068 40.2068 105.902 105.902 105.902 105.902 0.0 58.3303 0.0 58.3303 58.3303 40.2068 105.902 0 1 0 1 102551184 HIST1H4A_32934 58.3303 58.3303 40.2068 40.2068 105.902 105.902 58.3303 40.2068 105.902 0 Linear,1(1) 1.6554155349731445 1.6554155349731445 1.6554155349731445 1.6554155349731445 0.0 1.6554155349731445 58.3303 58.3303 40.2068 40.2068 105.902 105.902 DOWN 0.0 1.0 0.0 GO:0045892 8 negative regulation of transcription, DNA-templated 221 232 7 7 5 7 5 5 91 227 2224 0.11556 0.94742 0.20748 2.16 78968;25664;65035;259241;58868 srebf1;pparg;nr1i3;nr1d2;fzd1 SREBF1_32750;PPARG_32510;NR1I3_32602;NR1D2_9358;FZD1_8671 25664(0.0441) 49.54812 41.2009 22.095 31.526701107109208 46.218135883823585 26.184886796823573 28.91556 31.4864 12.9529 15.035434487336904 29.521872048520017 14.480202470806688 90.29866 101.057 55.8619 31.94866838927719 84.85109670051544 30.86270022004189 41.2009;60.1903;22.095;99.0234;25.231 31.4864;43.9036;12.9529;42.5557;13.6792 60.0774;101.057;55.8619;102.838;131.659 5 0 5 78968;25664;65035;259241;58868 SREBF1_32750;PPARG_32510;NR1I3_32602;NR1D2_9358;FZD1_8671 49.54812 41.2009 31.526701107109208 28.91556 31.4864 15.035434487336904 90.29866 101.057 31.94866838927719 41.2009;60.1903;22.095;99.0234;25.231 31.4864;43.9036;12.9529;42.5557;13.6792 60.0774;101.057;55.8619;102.838;131.659 0 0 Exp 2,2(0.4);Poly 2,2(0.4);Power,1(0.2) 1.9008870346541271 9.740548849105835 1.5124053955078125 2.7270524501800537 0.4978203521926055 1.912555456161499 21.91374806152891 77.1824919384711 15.736420594707434 42.09469940529257 62.29441743086318 118.30290256913682 UP 1.0 0.0 0.0 GO:0006732 5 coenzyme metabolic process 61 67 11 11 10 11 10 10 86 57 2394 0.99997 1.5052E-4 1.5052E-4 14.93 29142;298490;680308;364975;24763;681337;314304;192272;50559;170465 vnn1;ppcs;mthfd2;gcdh;acsm3;acot4;acot3;acot2;acot1;acaa2 VNN1_10157;PPCS_9540;MTHFD2_9261;GCDH_8693;ACSM3_7976;ACOT4_7971;ACOT3_7970;ACOT2_7969;ACOT1_7968;ACAA2_7955 32.5116 24.6231 12.3157 22.642375338878796 34.769032680496615 26.79554837101653 23.491196000000002 20.758499999999998 6.70485 15.531940161488158 23.591274943195298 16.600870790072765 45.44601 32.373 16.9658 27.619658505912458 47.926535685478555 32.54099800781949 2.5 15.505600000000001 5.5 29.6986 20.7328;15.1091;57.4184;15.9021;52.2057;12.3157;30.8838;13.6362;28.5134;78.3988 16.8296;7.94061;46.387;10.4227;42.2655;6.70485;24.6874;11.3249;24.741;43.6084 26.7838;30.6311;79.7903;31.2818;71.1126;24.3993;41.2585;16.9658;33.4642;98.7727 9 1 9 29142;298490;680308;364975;24763;681337;314304;192272;50559 VNN1_10157;PPCS_9540;MTHFD2_9261;GCDH_8693;ACSM3_7976;ACOT4_7971;ACOT3_7970;ACOT2_7969;ACOT1_7968 27.41302222222222 20.7328 16.861568235322725 21.255951111111113 16.8296 14.669277898140935 39.52082222222222 31.2818 21.522962463597906 20.7328;15.1091;57.4184;15.9021;52.2057;12.3157;30.8838;13.6362;28.5134 16.8296;7.94061;46.387;10.4227;42.2655;6.70485;24.6874;11.3249;24.741 26.7838;30.6311;79.7903;31.2818;71.1126;24.3993;41.2585;16.9658;33.4642 1 170465 ACAA2_7955 78.3988 78.3988 43.6084 43.6084 98.7727 98.7727 78.3988 43.6084 98.7727 0 Exp 2,4(0.4);Hill,2(0.2);Linear,2(0.2);Poly 2,2(0.2) 3.2862372621748674 74.54378259181976 1.5464483499526978 50.888092041015625 15.301413324958236 2.4932953119277954 18.477710369372367 46.545489630627635 13.864399751217773 33.11799224878223 28.327168301353606 62.56485169864639 UP 0.9 0.1 0.0 GO:1901565 5 organonitrogen compound catabolic process 128 143 3 3 2 3 2 2 94 141 2310 0.084949 0.97573 0.17135 1.4 114027;64515 dao;cdc20 DAO_8437;CDC20_8255 53.8513 53.8513 6.1336 67.48301850525063 75.90191512828075 59.845622492450275 26.993035 26.993035 2.43617 34.72865153236518 38.3408991860808 30.798233619559742 234.68635 234.68635 16.2027 308.98254098677654 335.64886240047184 274.0134172156797 6.1336;101.569 2.43617;51.5499 16.2027;453.17 1 1 1 114027 DAO_8437 6.1336 6.1336 2.43617 2.43617 16.2027 16.2027 6.1336 2.43617 16.2027 1 64515 CDC20_8255 101.569 101.569 51.5499 51.5499 453.17 453.17 101.569 51.5499 453.17 0 Exp 2,1(0.5);Hill,1(0.5) 1.7761263548502382 3.59207546710968 1.5293418169021606 2.0627336502075195 0.37716498235974383 1.79603773355484 -39.675391999999995 147.377992 -21.138420399999998 75.1244904 -193.541604 662.914304 CONFLICT 0.5 0.5 0.0 GO:0019731 5 antibacterial humoral response 13 17 1 1 1 1 1 1 95 16 2435 0.86738 0.48068 0.48068 5.88 84386 slpi SLPI_9890 53.7429 53.7429 53.7429 53.7429 37.8192 37.8192 37.8192 37.8192 92.543 92.543 92.543 92.543 0.0 53.7429 53.7429 37.8192 92.543 0 1 0 1 84386 SLPI_9890 53.7429 53.7429 37.8192 37.8192 92.543 92.543 53.7429 37.8192 92.543 0 Linear,1(1) 1.714035153388977 1.714035153388977 1.714035153388977 1.714035153388977 0.0 1.714035153388977 53.7429 53.7429 37.8192 37.8192 92.543 92.543 DOWN 0.0 1.0 0.0 GO:0042447 5 hormone catabolic process 7 11 2 2 2 2 2 2 94 9 2442 0.99313 0.061968 0.061968 18.18 360268;24950 sult1e1;srd5a1 SULT1E1_32446;SRD5A1_32503 44.2408 44.2408 29.2087 21.258599690948596 50.19088564276361 19.522321135243036 34.1211 34.1211 22.9308 15.825474027023656 38.550503966725714 14.532941518464494 65.7715 65.7715 39.9852 36.467335183421326 75.97837019178927 33.48889572912079 0.0 29.2087 0.5 44.2408 59.2729;29.2087 45.3114;22.9308 91.5578;39.9852 1 1 1 360268 SULT1E1_32446 59.2729 59.2729 45.3114 45.3114 91.5578 91.5578 59.2729 45.3114 91.5578 1 24950 SRD5A1_32503 29.2087 29.2087 22.9308 22.9308 39.9852 39.9852 29.2087 22.9308 39.9852 0 Exp 2,1(0.5);Linear,1(0.5) 2.3974294162994068 4.896866798400879 1.9512832164764404 2.9455835819244385 0.7030765309445418 2.4484333992004395 14.777884 73.703716 12.188112000000004 56.05408799999999 15.230352000000003 116.312648 CONFLICT 0.5 0.5 0.0 GO:0000281 5 mitotic cytokinesis 13 16 3 3 2 3 2 2 94 14 2437 0.97966 0.11985 0.11985 12.5 308761;306575 prc1;ckap2 PRC1_9556;CKAP2_8324 72.2568 72.2568 64.2131 11.37550963166051 70.63972147352831 11.143264039699018 46.693200000000004 46.693200000000004 43.1133 5.062743131939361 45.97350888559793 4.959380749619942 162.199 162.199 125.437 51.989318979959705 154.80849055905222 50.9278904766978 0.0 64.2131 0.5 72.2568 80.3005;64.2131 50.2731;43.1133 198.961;125.437 0 2 0 2 308761;306575 PRC1_9556;CKAP2_8324 72.2568 72.2568 11.37550963166051 46.693200000000004 46.693200000000004 5.062743131939361 162.199 162.199 51.989318979959705 80.3005;64.2131 50.2731;43.1133 198.961;125.437 0 Linear,2(1) 2.1766211941687046 4.432697534561157 1.7985904216766357 2.6341071128845215 0.5907995181476426 2.2163487672805786 56.491147999999995 88.022452 39.67659600000001 53.709804 90.14547999999999 234.25252000000003 DOWN 0.0 1.0 0.0 GO:0065007 2 biological regulation 1742 1890 74 73 57 73 56 56 40 1834 617 3.9606E-4 0.99982 5.1847E-4 2.96 257644;29142;365813;360243;361604;360268;64305;78968;24950;64159;84386;299270;309607;24679;308761;25664;296371;363465;54133;24614;338475;65035;259241;291234;24552;315994;25626;303575;24484;25685;63868;24471;102551184;29455;299626;58868;65030;117543;25427;65210;499353;25413;306575;64515;25599;362485;114494;25612;25649;155423;502970;81633;50681;50559;170465;114628 zwint;vnn1;trim59;top2a;sytl2;sult1e1;sult1b1;srebf1;srd5a1;sptan1;slpi;serpina6;rt1-ce5;prkar2b;prc1;pparg;pltp;pir;pdlim1;orm1;nrep;nr1i3;nr1d2;mki67;me1;mapkapk3;krt8;kif18b;igfbp3;igfbp1;hspd1;hspb1;loc102551184;gdf15;gadd45b;fzd1;ephx2;decr1;cyp51;cyp2j4;cyp2c24;cpt2;ckap2;cdc20;cd74;ccne2;ccna2;asns;apoa2;anxa7;angptl3;acta2;acox1;acot1;acaa2;abcg5 ZWINT_10214;VNN1_10157;TRIM59_10085;TOP2A_10059;SYTL2_32351;SULT1E1_32446;SULT1B1_32942;SREBF1_32750;SRD5A1_32503;SPTAN1_9932;SLPI_9890;SERPINA6_32325;RT1-CE5_32445;PRKAR2B_33052;PRC1_9556;PPARG_32510;PLTP_32412;PIR_9487;PDLIM1_9452;ORM1_9400;NREP_9364;NR1I3_32602;NR1D2_9358;MKI67_9232;ME1_9215;MAPKAPK3_9194;KRT8_8978;KIF18B_32882;IGFBP3_8881;IGFBP1_32306;HSPD1_8849;HSPB1_8847;HIST1H4A_32934;GDF15_33113;GADD45B_8679;FZD1_8671;EPHX2_33282;DECR1_8458;CYP51_8429;CYP2J4_32580;CYP2C24_32875;CPT2_8374;CKAP2_8324;CDC20_8255;CD74_8252;CCNE2_8227;CCNA2_8221;ASNS_8091;APOA2_33095;ANXA7_8051;ANGPTL3_8045;ACTA2_33040;ACOX1_7973;ACOT1_7968;ACAA2_7955;ABCG5_7947 25664(0.0441) 54.09505589285714 54.88915 3.54778 26.28372464525113 53.736266579222615 25.03454252773085 35.244490892857144 37.2603 1.51564 15.447600536623659 35.26981504032535 15.38283378091687 108.3593151785714 92.0504 8.55785 88.29576795505803 104.57173547268032 81.53993588975496 59.0663;20.7328;56.1278;54.9577;67.0093;59.2729;15.4629;41.2009;29.2087;47.5519;53.7429;68.3847;54.8206;108.746;80.3005;60.1903;87.0256;52.1607;67.1147;24.2519;69.4104;22.095;99.0234;49.7822;49.3339;104.193;68.9539;65.9823;50.946;98.8371;34.4455;41.6322;58.3303;21.3654;52.5718;25.231;6.44145;21.6199;75.1522;16.3155;58.9435;31.2175;64.2131;101.569;94.9138;77.8893;52.8265;28.1893;3.54778;64.7676;58.0729;90.3558;23.8014;28.5134;78.3988;33.1119 40.5797;16.8296;33.6269;18.8326;44.4373;45.3114;7.69418;31.4864;22.9308;34.4152;37.8192;36.9679;26.5902;59.3814;50.2731;43.9036;56.6266;40.9644;47.2419;19.7133;43.1468;12.9529;42.5557;35.6665;35.4173;59.1667;45.3374;43.9552;36.3081;57.328;26.6907;30.9494;40.2068;17.8875;37.1918;13.6792;2.66377;17.4928;48.098;8.2378;48.1505;24.8356;43.1133;51.5499;58.8146;49.2672;37.3288;23.1774;1.51564;43.3787;40.0757;70.2676;19.0993;24.741;43.6084;24.2098 108.188;26.7838;121.883;218.525;135.846;91.5578;35.0879;60.0774;39.9852;76.6397;92.543;89.5095;147.824;147.467;198.961;101.057;104.563;74.9097;123.914;31.358;157.944;55.8619;102.838;82.1147;80.9924;434.985;143.578;131.93;85.0816;357.409;48.4857;63.3196;105.902;26.3528;89.36;131.659;17.3473;28.0829;171.379;36.8422;80.4167;42.0237;125.437;453.17;118.773;185.461;90.0448;35.9474;8.55785;127.439;105.112;103.57;31.3543;33.4642;98.7727;50.4329 35 21 35 257644;29142;360268;64305;78968;64159;299270;24679;25664;296371;363465;54133;24614;65035;259241;24552;25626;25685;63868;24471;29455;299626;58868;65030;117543;65210;499353;25413;25599;25612;25649;155423;502970;50681;50559 ZWINT_10214;VNN1_10157;SULT1E1_32446;SULT1B1_32942;SREBF1_32750;SPTAN1_9932;SERPINA6_32325;PRKAR2B_33052;PPARG_32510;PLTP_32412;PIR_9487;PDLIM1_9452;ORM1_9400;NR1I3_32602;NR1D2_9358;ME1_9215;KRT8_8978;IGFBP1_32306;HSPD1_8849;HSPB1_8847;GDF15_33113;GADD45B_8679;FZD1_8671;EPHX2_33282;DECR1_8458;CYP2J4_32580;CYP2C24_32875;CPT2_8374;CD74_8252;ASNS_8091;APOA2_33095;ANXA7_8051;ANGPTL3_8045;ACOX1_7973;ACOT1_7968 47.456995142857146 47.5519 27.82826788651829 31.808236857142855 34.4152 16.312170327758487 81.03799285714287 76.6397 62.08452015205482 59.0663;20.7328;59.2729;15.4629;41.2009;47.5519;68.3847;108.746;60.1903;87.0256;52.1607;67.1147;24.2519;22.095;99.0234;49.3339;68.9539;98.8371;34.4455;41.6322;21.3654;52.5718;25.231;6.44145;21.6199;16.3155;58.9435;31.2175;94.9138;28.1893;3.54778;64.7676;58.0729;23.8014;28.5134 40.5797;16.8296;45.3114;7.69418;31.4864;34.4152;36.9679;59.3814;43.9036;56.6266;40.9644;47.2419;19.7133;12.9529;42.5557;35.4173;45.3374;57.328;26.6907;30.9494;17.8875;37.1918;13.6792;2.66377;17.4928;8.2378;48.1505;24.8356;58.8146;23.1774;1.51564;43.3787;40.0757;19.0993;24.741 108.188;26.7838;91.5578;35.0879;60.0774;76.6397;89.5095;147.467;101.057;104.563;74.9097;123.914;31.358;55.8619;102.838;80.9924;143.578;357.409;48.4857;63.3196;26.3528;89.36;131.659;17.3473;28.0829;36.8422;80.4167;42.0237;118.773;35.9474;8.55785;127.439;105.112;31.3543;33.4642 21 365813;360243;361604;24950;84386;309607;308761;338475;291234;315994;303575;24484;102551184;25427;306575;64515;362485;114494;81633;170465;114628 TRIM59_10085;TOP2A_10059;SYTL2_32351;SRD5A1_32503;SLPI_9890;RT1-CE5_32445;PRC1_9556;NREP_9364;MKI67_9232;MAPKAPK3_9194;KIF18B_32882;IGFBP3_8881;HIST1H4A_32934;CYP51_8429;CKAP2_8324;CDC20_8255;CCNE2_8227;CCNA2_8221;ACTA2_33040;ACAA2_7955;ABCG5_7947 65.15849047619048 64.2131 19.433513755543636 40.971580952380954 43.1133 12.19741789665416 153.8948523809524 125.437 106.78627353362707 56.1278;54.9577;67.0093;29.2087;53.7429;54.8206;80.3005;69.4104;49.7822;104.193;65.9823;50.946;58.3303;75.1522;64.2131;101.569;77.8893;52.8265;90.3558;78.3988;33.1119 33.6269;18.8326;44.4373;22.9308;37.8192;26.5902;50.2731;43.1468;35.6665;59.1667;43.9552;36.3081;40.2068;48.098;43.1133;51.5499;49.2672;37.3288;70.2676;43.6084;24.2098 121.883;218.525;135.846;39.9852;92.543;147.824;198.961;157.944;82.1147;434.985;131.93;85.0816;105.902;171.379;125.437;453.17;185.461;90.0448;103.57;98.7727;50.4329 0 Exp 2,18(0.33);Exp 4,3(0.06);Hill,1(0.02);Linear,25(0.45);Poly 2,7(0.13);Power,2(0.04) 2.0390470199360675 161.41512715816498 1.5062377452850342 50.888092041015625 6.570263338584149 1.768297255039215 47.21092741989862 60.97918436581568 31.198516886951765 39.29046489876251 85.233239311277 131.4853910458659 UP 0.625 0.375 0.0 GO:0001817 5 regulation of cytokine production 196 207 9 9 8 9 8 8 88 199 2252 0.62223 0.52603 0.84994 3.86 309607;25664;24614;63868;24471;65210;25599;25649 rt1-ce5;pparg;orm1;hspd1;hspb1;cyp2j4;cd74;apoa2 RT1-CE5_32445;PPARG_32510;ORM1_9400;HSPD1_8849;HSPB1_8847;CYP2J4_32580;CD74_8252;APOA2_33095 25664(0.0441) 41.2646975 38.03885 3.54778 28.788061103362057 42.24026571026673 29.75341564350038 27.051904999999998 26.64045 1.51564 18.393745157049608 27.683074401209705 19.112187849897502 69.52716875000002 55.90265 8.55785 48.21588906601622 70.0985108021381 47.369784070808365 54.8206;60.1903;24.2519;34.4455;41.6322;16.3155;94.9138;3.54778 26.5902;43.9036;19.7133;26.6907;30.9494;8.2378;58.8146;1.51564 147.824;101.057;31.358;48.4857;63.3196;36.8422;118.773;8.55785 7 1 7 25664;24614;63868;24471;65210;25599;25649 PPARG_32510;ORM1_9400;HSPD1_8849;HSPB1_8847;CYP2J4_32580;CD74_8252;APOA2_33095 39.32814 34.4455 30.526635793983814 27.117862857142857 26.6907 19.866493574768644 58.34190714285715 48.4857 39.30063482237942 60.1903;24.2519;34.4455;41.6322;16.3155;94.9138;3.54778 43.9036;19.7133;26.6907;30.9494;8.2378;58.8146;1.51564 101.057;31.358;48.4857;63.3196;36.8422;118.773;8.55785 1 309607 RT1-CE5_32445 54.8206 54.8206 26.5902 26.5902 147.824 147.824 54.8206 26.5902 147.824 0 Exp 2,4(0.5);Exp 4,1(0.13);Hill,1(0.13);Linear,1(0.13);Poly 2,1(0.13) 1.9021820992103928 15.783564925193787 1.5239794254302979 3.5849626064300537 0.6647950204744367 1.7865503430366516 21.31558894106801 61.21380605893198 14.305689906672349 39.79812009332765 36.11526227287198 102.93907522712803 UP 0.875 0.125 0.0 GO:0042176 6 regulation of protein catabolic process 106 112 3 3 2 3 2 2 94 110 2341 0.19544 0.93142 0.44019 1.79 25427;64515 cyp51;cdc20 CYP51_8429;CDC20_8255 88.3606 88.3606 75.1522 18.679498417248727 94.89213886963076 16.235814149866265 49.823949999999996 49.823949999999996 48.098 2.4408618979779404 50.677430324039186 2.1215441258563454 312.2745 312.2745 171.379 199.25632697733852 381.9471654860588 173.18926990040555 75.1522;101.569 48.098;51.5499 171.379;453.17 0 2 0 2 25427;64515 CYP51_8429;CDC20_8255 88.3606 88.3606 18.679498417248727 49.823949999999996 49.823949999999996 2.4408618979779404 312.2745 312.2745 199.25632697733852 75.1522;101.569 48.098;51.5499 171.379;453.17 0 Exp 2,1(0.5);Linear,1(0.5) 1.580622884262983 3.1629652976989746 1.5293418169021606 1.633623480796814 0.07373827169332572 1.5814826488494873 62.472136 114.249064 46.44108799999999 53.206812 36.11931999999996 588.42968 DOWN 0.0 1.0 0.0 GO:0060341 5 regulation of cellular localization 248 267 4 4 3 4 3 3 93 264 2187 0.0065812 0.99843 0.010632 1.12 78968;309607;362485 srebf1;rt1-ce5;ccne2 SREBF1_32750;RT1-CE5_32445;CCNE2_8227 57.97026666666667 54.8206 41.2009 18.54588832392058 51.32092462308699 15.463156942149771 35.78126666666667 31.4864 26.5902 11.93297917593646 32.38537202025374 8.988378318780269 131.1208 147.824 60.0774 64.33901969194125 109.01765990783412 62.33610726061095 41.2009;54.8206;77.8893 31.4864;26.5902;49.2672 60.0774;147.824;185.461 1 2 1 78968 SREBF1_32750 41.2009 41.2009 31.4864 31.4864 60.0774 60.0774 41.2009 31.4864 60.0774 2 309607;362485 RT1-CE5_32445;CCNE2_8227 66.35495 66.35495 16.312034203158106 37.9287 37.9287 16.03506047696736 166.6425 166.6425 26.61337792351819 54.8206;77.8893 26.5902;49.2672 147.824;185.461 0 Exp 2,2(0.67);Linear,1(0.34) 1.7776595421997539 5.349878668785095 1.589782476425171 1.912555456161499 0.17070863615191503 1.8475407361984253 36.983618378961154 78.95691495437218 22.277829537322877 49.28470379601046 58.31434533646376 203.92725466353625 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0010975 8 regulation of neuron projection development 121 127 3 3 3 3 3 3 93 124 2327 0.2841 0.8679 0.62885 2.36 24471;58868;64515 hspb1;fzd1;cdc20 HSPB1_8847;FZD1_8671;CDC20_8255 56.144066666666674 41.6322 25.231 40.18480143802295 56.07183465901682 39.376700911555325 32.0595 30.9494 13.6792 18.959739479486522 32.412126952666576 18.362337641830067 216.04953333333333 131.659 63.3196 208.17577952839122 209.90094138740383 208.7378575503113 41.6322;25.231;101.569 30.9494;13.6792;51.5499 63.3196;131.659;453.17 2 1 2 24471;58868 HSPB1_8847;FZD1_8671 33.4316 33.4316 11.597399739596785 22.3143 22.3143 12.21187553244792 97.4893 97.4893 48.323253162219935 41.6322;25.231 30.9494;13.6792 63.3196;131.659 1 64515 CDC20_8255 101.569 101.569 51.5499 51.5499 453.17 453.17 101.569 51.5499 453.17 0 Exp 2,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 1.6225621141919346 4.888595461845398 1.5124053955078125 1.8468482494354248 0.1883919671026755 1.5293418169021606 10.6706830486212 101.61745028471215 10.604535043196428 53.51446495680357 -19.523537671641236 451.6226043383079 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0006633 6 fatty acid biosynthetic process 33 37 3 3 2 3 2 2 94 35 2416 0.83883 0.40983 0.64869 5.41 25599;24763 cd74;acsm3 CD74_8252;ACSM3_7976 73.55975 73.55975 52.2057 30.19918712159323 86.77096045180723 23.725908614869105 50.54005 50.54005 42.2655 11.701980832534279 55.659304728915664 9.193629177095936 94.9428 94.9428 71.1126 33.70099203406325 109.68594180722891 26.47709204923904 0.5 73.55975 94.9138;52.2057 58.8146;42.2655 118.773;71.1126 2 0 2 25599;24763 CD74_8252;ACSM3_7976 73.55975 73.55975 30.19918712159323 50.54005 50.54005 11.701980832534279 94.9428 94.9428 33.70099203406325 94.9138;52.2057 58.8146;42.2655 118.773;71.1126 0 0 Exp 2,1(0.5);Poly 2,1(0.5) 2.08263057444021 4.274166941642761 1.6577342748641968 2.6164326667785645 0.6779021340352878 2.1370834708213806 31.705812 115.41368799999998 34.321932000000004 66.758168 48.23560800000001 141.649992 UP 1.0 0.0 0.0 GO:0009890 6 negative regulation of biosynthetic process 293 306 10 10 7 10 7 7 89 299 2152 0.092853 0.95448 0.19819 2.29 78968;25664;65035;259241;63868;58868;65210 srebf1;pparg;nr1i3;nr1d2;hspd1;fzd1;cyp2j4 SREBF1_32750;PPARG_32510;NR1I3_32602;NR1D2_9358;HSPD1_8849;FZD1_8671;CYP2J4_32580 25664(0.0441) 42.64308571428571 34.4455 16.3155 28.793723865652183 39.07189707761779 24.54030021011738 25.643757142857144 26.6907 8.2378 14.501977244368797 25.084258298543066 14.667681546489488 76.68874285714286 60.0774 36.8422 35.100278903538516 71.33514331387919 33.160753222785985 41.2009;60.1903;22.095;99.0234;34.4455;25.231;16.3155 31.4864;43.9036;12.9529;42.5557;26.6907;13.6792;8.2378 60.0774;101.057;55.8619;102.838;48.4857;131.659;36.8422 7 0 7 78968;25664;65035;259241;63868;58868;65210 SREBF1_32750;PPARG_32510;NR1I3_32602;NR1D2_9358;HSPD1_8849;FZD1_8671;CYP2J4_32580 42.64308571428571 34.4455 28.793723865652183 25.643757142857144 26.6907 14.501977244368797 76.68874285714286 60.0774 35.100278903538516 41.2009;60.1903;22.095;99.0234;34.4455;25.231;16.3155 31.4864;43.9036;12.9529;42.5557;26.6907;13.6792;8.2378 60.0774;101.057;55.8619;102.838;48.4857;131.659;36.8422 0 0 Exp 2,3(0.43);Exp 4,1(0.15);Poly 2,2(0.29);Power,1(0.15) 1.8692612828403914 13.336796045303345 1.5124053955078125 2.7270524501800537 0.42110306345761345 1.912555456161499 21.312396567251014 63.97377486132042 14.900542056808213 36.386972228906075 50.68609235736733 102.69139335691841 UP 1.0 0.0 0.0 GO:0009612 4 response to mechanical stimulus 121 126 4 4 3 4 3 3 93 123 2328 0.29002 0.86431 0.62791 2.38 25664;24471;25612 pparg;hspb1;asns PPARG_32510;HSPB1_8847;ASNS_8091 25664(0.0441) 43.337266666666665 41.6322 28.1893 16.06849213533533 48.35165414390062 15.295919003068935 32.6768 30.9494 23.1774 10.470519312813467 35.926134376258126 10.123251887936933 66.77466666666668 63.3196 35.9474 32.69201916819046 76.97695942945879 31.116638594802552 60.1903;41.6322;28.1893 43.9036;30.9494;23.1774 101.057;63.3196;35.9474 3 0 3 25664;24471;25612 PPARG_32510;HSPB1_8847;ASNS_8091 43.337266666666665 41.6322 16.06849213533533 32.6768 30.9494 10.470519312813467 66.77466666666668 63.3196 32.69201916819046 60.1903;41.6322;28.1893 43.9036;30.9494;23.1774 101.057;63.3196;35.9474 0 0 Exp 2,2(0.67);Linear,1(0.34) 2.09372320873514 6.631802797317505 1.5239794254302979 3.2609751224517822 0.9238644509137174 1.8468482494354248 25.15405607744448 61.52047725588885 20.82829199813625 44.52530800186375 29.7801643751366 103.76916895819673 UP 1.0 0.0 0.0 GO:0008211 5 glucocorticoid metabolic process 8 9 2 2 1 2 1 1 95 8 2443 0.95741 0.29272 0.29272 11.11 299270 serpina6 SERPINA6_32325 68.3847 68.3847 68.3847 68.3847 36.9679 36.9679 36.9679 36.9679 89.5095 89.5095 89.5095 89.5095 0.0 68.3847 0.0 68.3847 68.3847 36.9679 89.5095 1 0 1 299270 SERPINA6_32325 68.3847 68.3847 36.9679 36.9679 89.5095 89.5095 68.3847 36.9679 89.5095 0 0 Poly 2,1(1) 1.8690931797027588 1.8690931797027588 1.8690931797027588 1.8690931797027588 0.0 1.8690931797027588 68.3847 68.3847 36.9679 36.9679 89.5095 89.5095 UP 1.0 0.0 0.0 GO:0001701 7 in utero embryonic development 63 65 1 1 1 1 1 1 95 64 2387 0.28794 0.92033 0.51578 1.54 25413 cpt2 CPT2_8374 31.2175 31.2175 31.2175 31.2175 24.8356 24.8356 24.8356 24.8356 42.0237 42.0237 42.0237 42.0237 31.2175 24.8356 42.0237 1 0 1 25413 CPT2_8374 31.2175 31.2175 24.8356 24.8356 42.0237 42.0237 31.2175 24.8356 42.0237 0 0 Exp 2,1(1) 1.8769218921661377 1.8769218921661377 1.8769218921661377 1.8769218921661377 0.0 1.8769218921661377 31.2175 31.2175 24.8356 24.8356 42.0237 42.0237 UP 1.0 0.0 0.0 GO:0042403 5 thyroid hormone metabolic process 7 8 1 1 1 1 1 1 95 7 2444 0.96606 0.26493 0.26493 12.5 64305 sult1b1 SULT1B1_32942 15.4629 15.4629 15.4629 15.4629 7.69418 7.69418 7.69418 7.69418 35.0879 35.0879 35.0879 35.0879 0.0 15.4629 0.0 15.4629 15.4629 7.69418 35.0879 1 0 1 64305 SULT1B1_32942 15.4629 15.4629 7.69418 7.69418 35.0879 35.0879 15.4629 7.69418 35.0879 0 0 Exp 4,1(1) 1.619360327720642 1.619360327720642 1.619360327720642 1.619360327720642 0.0 1.619360327720642 15.4629 15.4629 7.69418 7.69418 35.0879 35.0879 UP 1.0 0.0 0.0 GO:0019369 6 arachidonic acid metabolic process 29 34 9 9 9 9 9 9 87 25 2426 1.0 2.5344E-6 2.5344E-6 26.47 25315;50549;65210;25086;24303;499353;171521;29277;24894 ephx1;cyp4a1;cyp2j4;cyp2e1;cyp2d3;cyp2c24;cyp2c13;cyp2c11;cyp2a1 EPHX1_8567;CYP4A1_33111;CYP2J4_32580;CYP2E1_8421;CYP2D3_8420;CYP2C24_32875;CYP2C13_8419;CYP2C11_32593;CYP2A1_32717 35.734545555555556 23.208 7.89174 31.953501265189665 39.893417399172954 34.52605730458927 23.62228111111111 18.863 4.16797 18.979552826276258 25.663928244709314 20.15997146663905 48.482400000000005 36.8422 15.8079 32.358042263052624 53.60515742966026 33.914560479040205 0.5 8.631805 2.5 14.5607 34.0134;23.208;16.3155;7.89174;12.8059;58.9435;104.635;54.426;9.37187 26.1579;18.863;8.2378;4.16797;8.8664;48.1505;49.2461;43.9518;4.95906 48.3681;29.9853;36.8422;15.8079;22.6004;80.4167;108.327;74.8861;19.1079 9 0 9 25315;50549;65210;25086;24303;499353;171521;29277;24894 EPHX1_8567;CYP4A1_33111;CYP2J4_32580;CYP2E1_8421;CYP2D3_8420;CYP2C24_32875;CYP2C13_8419;CYP2C11_32593;CYP2A1_32717 35.734545555555556 23.208 31.953501265189665 23.62228111111111 18.863 18.979552826276258 48.482400000000005 36.8422 32.358042263052624 34.0134;23.208;16.3155;7.89174;12.8059;58.9435;104.635;54.426;9.37187 26.1579;18.863;8.2378;4.16797;8.8664;48.1505;49.2461;43.9518;4.95906 48.3681;29.9853;36.8422;15.8079;22.6004;80.4167;108.327;74.8861;19.1079 0 0 Exp 2,3(0.34);Exp 4,3(0.34);Linear,1(0.12);Poly 2,1(0.12);Power,1(0.12) 2.0733330840401636 19.133623003959656 1.5310101509094238 2.9415390491485596 0.5112945351841247 2.000227451324463 14.858258062298304 56.61083304881281 11.222306597943957 36.022255624278266 27.34181238813895 69.62298761186105 UP 1.0 0.0 0.0 GO:0008104 4 protein localization 289 309 7 7 5 7 5 5 91 304 2147 0.017631 0.99391 0.036628 1.62 361604;25664;63868;24471;25599 sytl2;pparg;hspd1;hspb1;cd74 SYTL2_32351;PPARG_32510;HSPD1_8849;HSPB1_8847;CD74_8252 25664(0.0441) 59.638220000000004 60.1903 34.4455 23.758651341500844 62.455985841624006 23.59380271285449 40.95912 43.9036 26.6907 12.68235159964429 42.600996276381615 12.474535569642486 93.49626 101.057 48.4857 36.8312373289033 97.53758395249871 34.89060411319415 67.0093;60.1903;34.4455;41.6322;94.9138 44.4373;43.9036;26.6907;30.9494;58.8146 135.846;101.057;48.4857;63.3196;118.773 4 1 4 25664;63868;24471;25599 PPARG_32510;HSPD1_8849;HSPB1_8847;CD74_8252 57.79545 50.911249999999995 27.01837664016844 40.089574999999996 37.4265 14.471189748917217 82.90882500000001 82.1883 32.57956708903856 60.1903;34.4455;41.6322;94.9138 43.9036;26.6907;30.9494;58.8146 101.057;48.4857;63.3196;118.773 1 361604 SYTL2_32351 67.0093 67.0093 44.4373 44.4373 135.846 135.846 67.0093 44.4373 135.846 0 Exp 2,2(0.4);Linear,2(0.4);Poly 2,1(0.2) 1.6349518629060635 8.196498394012451 1.512166976928711 1.8468482494354248 0.13523034252915647 1.6557694673538208 38.81284389430151 80.46359610569849 29.84254868578774 52.07569131421227 61.212257057760624 125.78026294223939 UP 0.8 0.2 0.0 GO:1901362 5 organic cyclic compound biosynthetic process 212 234 14 13 10 14 9 9 87 225 2226 0.61315 0.52767 0.85814 3.85 78968;24950;298490;313245;296371;364975;114027;25427;65155 srebf1;srd5a1;ppcs;polr1e;pltp;gcdh;dao;cyp51;alas1 SREBF1_32750;SRD5A1_32503;PPCS_9540;POLR1E_9523;PLTP_32412;GCDH_8693;DAO_8437;CYP51_8429;ALAS1_8018 41.210944444444436 29.2087 6.1336 30.037473024004168 42.576296819355356 28.68157120825038 27.672420000000002 22.9308 2.43617 19.528337477987602 29.3084456548934 18.59117992141031 72.94485555555555 39.9852 16.2027 59.80271200330531 64.78957442974634 44.80596889032317 41.2009;29.2087;15.1091;73.982;87.0256;15.9021;6.1336;75.1522;27.1843 31.4864;22.9308;7.94061;47.589;56.6266;10.4227;2.43617;48.098;21.5215 60.0774;39.9852;30.6311;165.722;104.563;31.2818;16.2027;171.379;36.6615 7 2 7 78968;298490;313245;296371;364975;114027;65155 SREBF1_32750;PPCS_9540;POLR1E_9523;PLTP_32412;GCDH_8693;DAO_8437;ALAS1_8018 38.0768 27.1843 31.23346377194392 25.431854285714287 21.5215 20.720438764789588 63.59135714285714 36.6615 53.57686019302417 41.2009;15.1091;73.982;87.0256;15.9021;6.1336;27.1843 31.4864;7.94061;47.589;56.6266;10.4227;2.43617;21.5215 60.0774;30.6311;165.722;104.563;31.2818;16.2027;36.6615 2 24950;25427 SRD5A1_32503;CYP51_8429 52.18044999999999 52.18044999999999 32.48696040144416 35.5144 35.5144 17.795897783478058 105.68209999999999 105.68209999999999 92.909446985869 29.2087;75.1522 22.9308;48.098 39.9852;171.379 0 Exp 2,1(0.12);Hill,2(0.23);Linear,4(0.45);Poly 2,2(0.23) 1.7523643745774957 15.874678134918213 1.5084086656570435 2.0627336502075195 0.21242782939242208 1.8392632007598877 21.58646206876172 60.835426820127154 14.913906181048102 40.4309338189519 33.87375038006275 112.01596073104838 UP 0.7777777777777778 0.2222222222222222 0.0 GO:0046683 5 response to organophosphorus 70 72 5 5 4 5 4 4 92 68 2383 0.86746 0.28663 0.34705 5.56 78968;24950;63868;65155 srebf1;srd5a1;hspd1;alas1 SREBF1_32750;SRD5A1_32503;HSPD1_8849;ALAS1_8018 33.00985 31.8271 27.1843 6.25939733920129 34.751086188719036 6.612067003009834 25.65735 24.81075 21.5215 4.45664171957615 26.89752064663504 4.706429769016463 46.30244999999999 44.23545 36.6615 10.446233651895815 49.21854594095941 11.062737114850355 2.5 37.8232 41.2009;29.2087;34.4455;27.1843 31.4864;22.9308;26.6907;21.5215 60.0774;39.9852;48.4857;36.6615 3 1 3 78968;63868;65155 SREBF1_32750;HSPD1_8849;ALAS1_8018 34.276900000000005 34.4455 7.009820850777833 26.5662 26.6907 4.983616477017466 48.4082 48.4857 11.708142375714406 41.2009;34.4455;27.1843 31.4864;26.6907;21.5215 60.0774;48.4857;36.6615 1 24950 SRD5A1_32503 29.2087 29.2087 22.9308 22.9308 39.9852 39.9852 29.2087 22.9308 39.9852 0 Exp 2,2(0.5);Linear,2(0.5) 1.836092363618124 7.358871340751648 1.6557694673538208 1.9512832164764404 0.13113525085757316 1.8759093284606934 26.875640607582753 39.14405939241725 21.289841114815374 30.024858885184628 36.065141021142125 56.539758978857876 UP 0.75 0.25 0.0 GO:0008203 6 cholesterol metabolic process 48 49 7 6 5 7 4 4 92 45 2406 0.96479 0.11073 0.11073 8.16 78968;25427;25649;502970 srebf1;cyp51;apoa2;angptl3 SREBF1_32750;CYP51_8429;APOA2_33095;ANGPTL3_8045 44.493444999999994 49.6369 3.54778 30.6145346260906 41.09840869732669 25.86841672792172 30.293935 35.78105 1.51564 20.349282484670066 28.93502450989276 17.99400564008717 86.2815625 82.59469999999999 8.55785 69.09846323090181 72.25317711637216 51.61913164961168 1.5 49.6369 41.2009;75.1522;3.54778;58.0729 31.4864;48.098;1.51564;40.0757 60.0774;171.379;8.55785;105.112 3 1 3 78968;25649;502970 SREBF1_32750;APOA2_33095;ANGPTL3_8045 34.27386 41.2009 27.914782645129083 24.359246666666667 31.4864 20.243932245947995 57.91575 60.0774 48.31335755872799 41.2009;3.54778;58.0729 31.4864;1.51564;40.0757 60.0774;8.55785;105.112 1 25427 CYP51_8429 75.1522 75.1522 48.098 48.098 171.379 171.379 75.1522 48.098 171.379 0 Exp 2,1(0.25);Hill,1(0.25);Linear,2(0.5) 1.6969845651668507 6.810023903846741 1.5375925302505493 1.912555456161499 0.15981856509108094 1.6799379587173462 14.491201066431227 74.49568893356877 10.351638165023328 50.236231834976664 18.56506853371623 153.9980564662838 UP 0.75 0.25 0.0 GO:0046597 7 negative regulation of viral entry into host cell 5 5 1 1 1 1 1 1 95 4 2447 0.98695 0.1749 0.1749 20.0 365813 trim59 TRIM59_10085 56.1278 56.1278 56.1278 56.1278 33.6269 33.6269 33.6269 33.6269 121.883 121.883 121.883 121.883 0.0 56.1278 0.0 56.1278 56.1278 33.6269 121.883 0 1 0 1 365813 TRIM59_10085 56.1278 56.1278 33.6269 33.6269 121.883 121.883 56.1278 33.6269 121.883 0 Exp 2,1(1) 1.528815746307373 1.528815746307373 1.528815746307373 1.528815746307373 0.0 1.528815746307373 56.1278 56.1278 33.6269 33.6269 121.883 121.883 DOWN 0.0 1.0 0.0 GO:0045091 8 regulation of single stranded viral RNA replication via double stranded DNA intermediate 1 1 1 1 1 1 1 1 95 0 2451 1.0 0.037691 0.037691 100.0 360243 top2a TOP2A_10059 54.9577 54.9577 54.9577 54.9577 18.8326 18.8326 18.8326 18.8326 218.525 218.525 218.525 218.525 0.0 54.9577 0.0 54.9577 54.9577 18.8326 218.525 0 1 0 1 360243 TOP2A_10059 54.9577 54.9577 18.8326 18.8326 218.525 218.525 54.9577 18.8326 218.525 0 Exp 2,1(1) 1.8061060905456543 1.8061060905456543 1.8061060905456543 1.8061060905456543 0.0 1.8061060905456543 54.9577 54.9577 18.8326 18.8326 218.525 218.525 DOWN 0.0 1.0 0.0 GO:0045870 8 positive regulation of single stranded viral RNA replication via double stranded DNA intermediate 1 1 1 1 1 1 1 1 95 0 2451 1.0 0.037691 0.037691 100.0 360243 top2a TOP2A_10059 54.9577 54.9577 54.9577 54.9577 18.8326 18.8326 18.8326 18.8326 218.525 218.525 218.525 218.525 0.0 54.9577 0.0 54.9577 54.9577 18.8326 218.525 0 1 0 1 360243 TOP2A_10059 54.9577 54.9577 18.8326 18.8326 218.525 218.525 54.9577 18.8326 218.525 0 Exp 2,1(1) 1.8061060905456543 1.8061060905456543 1.8061060905456543 1.8061060905456543 0.0 1.8061060905456543 54.9577 54.9577 18.8326 18.8326 218.525 218.525 DOWN 0.0 1.0 0.0 GO:0051346 6 negative regulation of hydrolase activity 118 128 7 7 5 7 5 5 91 123 2328 0.64837 0.53482 0.81308 3.91 361604;84386;299270;25649;502970 sytl2;slpi;serpina6;apoa2;angptl3 SYTL2_32351;SLPI_9890;SERPINA6_32325;APOA2_33095;ANGPTL3_8045 50.151516 58.0729 3.54778 26.759056657686543 52.86665583789597 23.759822751001202 32.163148 37.8192 1.51564 17.37533883907074 33.954588223992964 15.325638851339022 86.31367 92.543 8.55785 47.17471343720068 89.88825014787838 41.670862887823354 67.0093;53.7429;68.3847;3.54778;58.0729 44.4373;37.8192;36.9679;1.51564;40.0757 135.846;92.543;89.5095;8.55785;105.112 3 2 3 299270;25649;502970 SERPINA6_32325;APOA2_33095;ANGPTL3_8045 43.33512666666667 58.0729 34.840465279472554 26.18641333333333 36.9679 21.421948974323822 67.72645 89.5095 51.83195849119054 68.3847;3.54778;58.0729 36.9679;1.51564;40.0757 89.5095;8.55785;105.112 2 361604;84386 SYTL2_32351;SLPI_9890 60.376099999999994 60.376099999999994 9.38076140193329 41.12825 41.12825 4.67970338857073 114.1945 114.1945 30.619844945721088 67.0093;53.7429 44.4373;37.8192 135.846;92.543 0 Hill,1(0.2);Linear,3(0.6);Poly 2,1(0.2) 1.6666300130259666 8.359140276908875 1.512166976928711 1.8690931797027588 0.14762098246076322 1.714035153388977 26.696168677460644 73.60686332253934 16.932991999708257 47.39330400029174 44.96321050265586 127.66412949734413 UP 0.6 0.4 0.0 GO:0018958 5 phenol-containing compound metabolic process 27 31 5 5 4 5 4 4 92 27 2424 0.99466 0.027321 0.027321 12.9 64305;24950;114027;25086 sult1b1;srd5a1;dao;cyp2e1 SULT1B1_32942;SRD5A1_32503;DAO_8437;CYP2E1_8421 14.674235 11.67732 6.1336 10.501068992356606 15.520260523205899 8.877821293835371 9.30728 5.931075 2.43617 9.342145519251275 9.386676518862682 8.052416121135618 26.770925 25.6453 15.8079 12.591854956379542 29.71954313923539 11.398720976869393 0.5 7.01267 2.5 22.3358 15.4629;29.2087;6.1336;7.89174 7.69418;22.9308;2.43617;4.16797 35.0879;39.9852;16.2027;15.8079 3 1 3 64305;114027;25086 SULT1B1_32942;DAO_8437;CYP2E1_8421 9.829413333333333 7.89174 4.957307039364553 4.7661066666666665 4.16797 2.679550875432921 22.36616666666667 16.2027 11.019112532928109 15.4629;6.1336;7.89174 7.69418;2.43617;4.16797 35.0879;16.2027;15.8079 1 24950 SRD5A1_32503 29.2087 29.2087 22.9308 22.9308 39.9852 39.9852 29.2087 22.9308 39.9852 0 Exp 4,2(0.5);Hill,1(0.25);Linear,1(0.25) 1.777343036614914 7.164387345314026 1.5310101509094238 2.0627336502075195 0.25598486111509533 1.7853217720985413 4.38318738749053 24.965282612509473 0.15197739113375341 18.46258260886625 14.43090714274805 39.11094285725195 UP 0.75 0.25 0.0 GO:0050673 4 epithelial cell proliferation 37 39 3 3 2 3 2 2 94 37 2414 0.82005 0.43627 0.6572 5.13 291234;24484 mki67;igfbp3 MKI67_9232;IGFBP3_8881 50.3641 50.3641 49.7822 0.8229308719449693 50.42295275626424 0.8187111371901739 35.987300000000005 35.987300000000005 35.6665 0.45367971080853614 36.019745375854214 0.4513533816996441 83.59815 83.59815 82.1147 2.0979151091016965 83.74818457858771 2.087157649879793 0.5 50.3641 49.7822;50.946 35.6665;36.3081 82.1147;85.0816 0 2 0 2 291234;24484 MKI67_9232;IGFBP3_8881 50.3641 50.3641 0.8229308719449693 35.987300000000005 35.987300000000005 0.45367971080853614 83.59815 83.59815 2.0979151091016965 49.7822;50.946 35.6665;36.3081 82.1147;85.0816 0 Linear,2(1) 1.9930949885205873 4.023630261421204 1.7380040884017944 2.285626173019409 0.38722728956062874 2.011815130710602 49.22357600000001 51.50462399999999 35.358532000000004 36.616068000000006 80.690588 86.505712 DOWN 0.0 1.0 0.0 GO:0043535 7 regulation of blood vessel endothelial cell migration 35 37 3 3 2 2 2 2 94 35 2416 0.83883 0.40983 0.64869 5.41 25664;24471 pparg;hspb1 PPARG_32510;HSPB1_8847 25664(0.0441) 50.911249999999995 50.911249999999995 41.6322 13.12255835593807 52.70761385508463 12.87430353864978 37.4265 37.4265 30.9494 9.160002664846768 38.68042452091201 8.986712158053757 82.1883 82.1883 63.3196 26.684371444349228 85.84115785424535 26.179551913150757 0.5 50.911249999999995 60.1903;41.6322 43.9036;30.9494 101.057;63.3196 2 0 2 25664;24471 PPARG_32510;HSPB1_8847 50.911249999999995 50.911249999999995 13.12255835593807 37.4265 37.4265 9.160002664846768 82.1883 82.1883 26.684371444349228 60.1903;41.6322 43.9036;30.9494 101.057;63.3196 0 0 Exp 2,1(0.5);Linear,1(0.5) 1.6776646667411073 3.3708276748657227 1.5239794254302979 1.8468482494354248 0.22830273488775124 1.6854138374328613 32.724312 69.098188 24.731384000000002 50.12161599999999 45.205648000000004 119.170952 UP 1.0 0.0 0.0 GO:0051051 5 negative regulation of transport 140 146 10 10 9 10 9 9 87 137 2314 0.95469 0.095497 0.11739 6.16 78968;309607;25664;24484;25427;25599;25649;170465;114628 srebf1;rt1-ce5;pparg;igfbp3;cyp51;cd74;apoa2;acaa2;abcg5 SREBF1_32750;RT1-CE5_32445;PPARG_32510;IGFBP3_8881;CYP51_8429;CD74_8252;APOA2_33095;ACAA2_7955;ABCG5_7947 25664(0.0441) 54.69803111111111 54.8206 3.54778 27.171094727737987 53.817376204504605 27.233215523395256 34.948304444444446 36.3081 1.51564 16.63753060126946 34.70982828263827 16.454833386507346 93.55060555555556 98.7727 8.55785 49.99716280743114 86.11927371050909 43.47264173021536 6.5 76.7755 41.2009;54.8206;60.1903;50.946;75.1522;94.9138;3.54778;78.3988;33.1119 31.4864;26.5902;43.9036;36.3081;48.098;58.8146;1.51564;43.6084;24.2098 60.0774;147.824;101.057;85.0816;171.379;118.773;8.55785;98.7727;50.4329 4 5 4 78968;25664;25599;25649 SREBF1_32750;PPARG_32510;CD74_8252;APOA2_33095 49.963195 50.6956 38.106513571987925 33.93006 37.695 24.3267885897776 72.11631249999999 80.5672 48.9864724558113 41.2009;60.1903;94.9138;3.54778 31.4864;43.9036;58.8146;1.51564 60.0774;101.057;118.773;8.55785 5 309607;24484;25427;170465;114628 RT1-CE5_32445;IGFBP3_8881;CYP51_8429;ACAA2_7955;ABCG5_7947 58.485899999999994 54.8206 18.630710763414292 35.7629 36.3081 10.38768923052668 110.69803999999999 98.7727 48.71041635023256 54.8206;50.946;75.1522;78.3988;33.1119 26.5902;36.3081;48.098;43.6084;24.2098 147.824;85.0816;171.379;98.7727;50.4329 0 Exp 2,4(0.45);Hill,1(0.12);Linear,2(0.23);Poly 2,2(0.23) 1.7929833717038204 16.30035972595215 1.5239794254302979 2.5319817066192627 0.2932751635150383 1.72868812084198 36.946249222322294 72.44981299989993 24.078451118281727 45.81815777060715 60.88579252136719 126.2154185897439 CONFLICT 0.4444444444444444 0.5555555555555556 0.0 GO:0060548 6 negative regulation of cell death 321 341 11 11 9 11 9 9 87 332 2119 0.15197 0.9137 0.28573 2.64 29142;309607;63868;24471;58868;25599;25612;50559;170465 vnn1;rt1-ce5;hspd1;hspb1;fzd1;cd74;asns;acot1;acaa2 VNN1_10157;RT1-CE5_32445;HSPD1_8849;HSPB1_8847;FZD1_8671;CD74_8252;ASNS_8091;ACOT1_7968;ACAA2_7955 45.208600000000004 34.4455 20.7328 25.883820594581856 53.428327188019956 27.710466835183077 29.453388888888885 26.5902 13.6792 13.92072705450801 33.4302426245147 15.360233516586725 78.33660000000002 63.3196 26.7838 46.515008323577646 90.02888900277316 43.46221987753139 20.7328;54.8206;34.4455;41.6322;25.231;94.9138;28.1893;28.5134;78.3988 16.8296;26.5902;26.6907;30.9494;13.6792;58.8146;23.1774;24.741;43.6084 26.7838;147.824;48.4857;63.3196;131.659;118.773;35.9474;33.4642;98.7727 7 2 7 29142;63868;24471;58868;25599;25612;50559 VNN1_10157;HSPD1_8849;HSPB1_8847;FZD1_8671;CD74_8252;ASNS_8091;ACOT1_7968 39.094 28.5134 25.50842702722638 27.840271428571423 24.741 14.85213737735126 65.49038571428572 48.4857 42.637734661620584 20.7328;34.4455;41.6322;25.231;94.9138;28.1893;28.5134 16.8296;26.6907;30.9494;13.6792;58.8146;23.1774;24.741 26.7838;48.4857;63.3196;131.659;118.773;35.9474;33.4642 2 309607;170465 RT1-CE5_32445;ACAA2_7955 66.6097 66.6097 16.672305108172566 35.0993 35.0993 12.033684623588915 123.29835 123.29835 34.68450685601577 54.8206;78.3988 26.5902;43.6084 147.824;98.7727 0 Exp 2,4(0.45);Linear,2(0.23);Poly 2,3(0.34) 2.9834345799312665 69.00655913352966 1.5124053955078125 50.888092041015625 16.240224985246197 1.8468482494354248 28.297837211539854 62.11936278846014 20.358513879943665 38.54826389783412 47.94679456192925 108.72640543807076 UP 0.7777777777777778 0.2222222222222222 0.0 GO:0010035 4 response to inorganic substance 271 293 10 10 8 10 8 8 88 285 2166 0.20682 0.87966 0.4142 2.73 25664;25626;63868;24471;25086;114494;155423;65155 pparg;krt8;hspd1;hspb1;cyp2e1;ccna2;anxa7;alas1 PPARG_32510;KRT8_8978;HSPD1_8849;HSPB1_8847;CYP2E1_8421;CCNA2_8221;ANXA7_8051;ALAS1_8018 25664(0.0441) 44.73650500000001 47.22935 7.89174 20.952848044384247 46.63275935084082 20.730350480538164 31.65975875 34.1391 4.16797 14.09275409059202 33.036463342778156 13.909775431208105 78.2991875 76.6822 15.8079 44.85534223489796 81.98810780234967 45.142166075451286 60.1903;68.9539;34.4455;41.6322;7.89174;52.8265;64.7676;27.1843 43.9036;45.3374;26.6907;30.9494;4.16797;37.3288;43.3787;21.5215 101.057;143.578;48.4857;63.3196;15.8079;90.0448;127.439;36.6615 7 1 7 25664;25626;63868;24471;25086;155423;65155 PPARG_32510;KRT8_8978;HSPD1_8849;HSPB1_8847;CYP2E1_8421;ANXA7_8051;ALAS1_8018 43.58079142857144 41.6322 22.354548948268086 30.849895714285715 30.9494 15.01949205396536 76.62124285714286 63.3196 48.177353235202986 60.1903;68.9539;34.4455;41.6322;7.89174;64.7676;27.1843 43.9036;45.3374;26.6907;30.9494;4.16797;43.3787;21.5215 101.057;143.578;48.4857;63.3196;15.8079;127.439;36.6615 1 114494 CCNA2_8221 52.8265 52.8265 37.3288 37.3288 90.0448 90.0448 52.8265 37.3288 90.0448 0 Exp 2,2(0.25);Exp 4,1(0.13);Linear,5(0.63) 1.7195497260928747 13.887749433517456 1.5239794254302979 2.3255980014801025 0.27023265113516637 1.6236008405685425 30.21692208139171 59.25608791860829 21.893978406608966 41.42553909339104 47.2160211665951 109.3823538334049 UP 0.875 0.125 0.0 GO:0002478 5 antigen processing and presentation of exogenous peptide antigen 11 15 2 2 2 2 2 2 94 13 2438 0.98302 0.10741 0.10741 13.33 309607;25599 rt1-ce5;cd74 RT1-CE5_32445;CD74_8252 74.8672 74.8672 54.8206 28.35017359946849 77.60461728586534 28.08461209142997 42.7024 42.7024 26.5902 22.786091759667787 44.902564356714834 22.57265007230838 133.2985 133.2985 118.773 20.542159100250554 131.31500380683823 20.349736760052185 0.0 54.8206 0.5 74.8672 54.8206;94.9138 26.5902;58.8146 147.824;118.773 1 1 1 25599 CD74_8252 94.9138 94.9138 58.8146 58.8146 118.773 118.773 94.9138 58.8146 118.773 1 309607 RT1-CE5_32445 54.8206 54.8206 26.5902 26.5902 147.824 147.824 54.8206 26.5902 147.824 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.7500661709215344 3.505275011062622 1.6577342748641968 1.8475407361984253 0.13421343592245522 1.752637505531311 35.575864 114.158536 11.122487999999997 74.28231199999999 104.82851999999998 161.76848 CONFLICT 0.5 0.5 0.0 GO:0014823 3 response to activity 61 66 4 4 3 4 3 3 93 63 2388 0.76395 0.45696 0.73693 4.55 24950;63868;114628 srd5a1;hspd1;abcg5 SRD5A1_32503;HSPD1_8849;ABCG5_7947 32.25536666666667 33.1119 29.2087 2.721443656101208 32.66208572635611 2.360127952851893 24.610433333333333 24.2098 22.9308 1.9116988003692952 24.694584763138625 1.7450242439265071 46.30126666666666 48.4857 39.9852 5.555845620905407 47.522521213316054 5.022480738193976 29.2087;34.4455;33.1119 22.9308;26.6907;24.2098 39.9852;48.4857;50.4329 1 2 1 63868 HSPD1_8849 34.4455 34.4455 26.6907 26.6907 48.4857 48.4857 34.4455 26.6907 48.4857 2 24950;114628 SRD5A1_32503;ABCG5_7947 31.1603 31.1603 2.7599791883273475 23.570300000000003 23.570300000000003 0.9043895731375391 45.20905 45.20905 7.387639517802694 29.2087;33.1119 22.9308;24.2098 39.9852;50.4329 0 Exp 2,2(0.67);Linear,1(0.34) 2.014931319763867 6.139034390449524 1.6557694673538208 2.5319817066192627 0.445774046016817 1.9512832164764404 29.175763260895216 35.33497007243812 22.44714249200807 26.773724174658597 40.01423549564746 52.588297837685865 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0043030 6 regulation of macrophage activation 14 16 2 2 2 2 2 2 94 14 2437 0.97966 0.11985 0.11985 12.5 25664;63868 pparg;hspd1 PPARG_32510;HSPD1_8849 25664(0.0441) 47.3179 47.3179 34.4455 18.204322660291428 50.11010199657729 17.77089135470192 35.29715 35.29715 26.6907 12.171358313885893 37.16400830718767 11.88156737668769 74.77135 74.77135 48.4857 37.173522725792346 80.47307185539076 36.28844895572861 0.0 34.4455 0.5 47.3179 60.1903;34.4455 43.9036;26.6907 101.057;48.4857 2 0 2 25664;63868 PPARG_32510;HSPD1_8849 47.3179 47.3179 18.204322660291428 35.29715 35.29715 12.171358313885893 74.77135 74.77135 37.173522725792346 60.1903;34.4455 43.9036;26.6907 101.057;48.4857 0 0 Exp 2,2(1) 1.5885082944394424 3.1797488927841187 1.5239794254302979 1.6557694673538208 0.09318963233698246 1.5898744463920593 22.087996000000004 72.547804 18.428508000000004 52.165791999999996 23.25147600000001 126.29122399999999 UP 1.0 0.0 0.0 GO:0048145 6 regulation of fibroblast proliferation 37 41 4 4 3 4 3 3 93 38 2413 0.93378 0.1993 0.1993 7.32 25664;25599;114494 pparg;cd74;ccna2 PPARG_32510;CD74_8252;CCNA2_8221 25664(0.0441) 69.3102 60.1903 52.8265 22.47698016482642 72.50839088105725 22.38918931774469 46.68233333333333 43.9036 37.3288 11.009128921641944 48.552480969162986 10.552134344762221 103.2916 101.057 90.0448 14.493876178579704 105.97946093000489 13.54861009047572 1.5 77.55205 60.1903;94.9138;52.8265 43.9036;58.8146;37.3288 101.057;118.773;90.0448 2 1 2 25664;25599 PPARG_32510;CD74_8252 77.55205 77.55205 24.55322231653108 51.3591 51.3591 10.543669214272617 109.91499999999999 109.91499999999999 12.527103735500948 60.1903;94.9138 43.9036;58.8146 101.057;118.773 1 114494 CCNA2_8221 52.8265 52.8265 37.3288 37.3288 90.0448 90.0448 52.8265 37.3288 90.0448 0 Exp 2,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 1.8044418405753786 5.507311701774597 1.5239794254302979 2.3255980014801025 0.42944240175381043 1.6577342748641968 43.875102524484475 94.74529747551551 34.224331182284914 59.14033548438175 86.89023510592396 119.69296489407601 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0001649 5 osteoblast differentiation 27 27 2 2 2 2 2 2 94 25 2426 0.92101 0.27078 0.27078 7.41 65035;24484 nr1i3;igfbp3 NR1I3_32602;IGFBP3_8881 36.5205 36.5205 22.095 20.40073774401308 34.04988890793759 20.099309992225017 24.6305 24.6305 12.9529 16.514620295968058 22.630513303617345 16.2706112346336 70.47175 70.47175 55.8619 20.66144801423652 67.9695658494771 20.35616818064598 0.5 36.5205 22.095;50.946 12.9529;36.3081 55.8619;85.0816 1 1 1 65035 NR1I3_32602 22.095 22.095 12.9529 12.9529 55.8619 55.8619 22.095 12.9529 55.8619 1 24484 IGFBP3_8881 50.946 50.946 36.3081 36.3081 85.0816 85.0816 50.946 36.3081 85.0816 0 Linear,1(0.5);Poly 2,1(0.5) 1.8942563132978705 3.8025602102279663 1.7380040884017944 2.064556121826172 0.23090715724463343 1.9012801051139832 8.246520000000004 64.79448 1.7424040000000005 47.518596 41.83644400000001 99.107056 CONFLICT 0.5 0.5 0.0 GO:0045936 8 negative regulation of phosphate metabolic process 156 168 8 8 5 8 5 5 91 163 2288 0.38322 0.77166 0.83272 2.98 361604;24679;24484;24471;299626 sytl2;prkar2b;igfbp3;hspb1;gadd45b SYTL2_32351;PRKAR2B_33052;IGFBP3_8881;HSPB1_8847;GADD45B_8679 64.18106 52.5718 41.6322 26.516153741408278 59.85823201159888 21.60700936168657 41.653600000000004 37.1918 30.9494 11.012331788272606 40.01757249308786 9.168404655685721 104.21484000000001 89.36 63.3196 35.81357084469517 100.98210936003777 33.232174565697306 67.0093;108.746;50.946;41.6322;52.5718 44.4373;59.3814;36.3081;30.9494;37.1918 135.846;147.467;85.0816;63.3196;89.36 3 2 3 24679;24471;299626 PRKAR2B_33052;HSPB1_8847;GADD45B_8679 67.64999999999999 52.5718 36.00804943398075 42.507533333333335 37.1918 14.942805012892784 100.04886666666668 89.36 43.07998531398696 108.746;41.6322;52.5718 59.3814;30.9494;37.1918 147.467;63.3196;89.36 2 361604;24484 SYTL2_32351;IGFBP3_8881 58.97765 58.97765 11.358468358233884 40.3727 40.3727 5.7482124456216495 110.46379999999999 110.46379999999999 35.89585148286642 67.0093;50.946 44.4373;36.3081 135.846;85.0816 0 Linear,4(0.8);Power,1(0.2) 1.6496258702831195 8.270621418952942 1.512166976928711 1.8468482494354248 0.13757445255832979 1.6208000183105469 40.93862647109127 87.42349352890871 32.000865592011095 51.3063344079889 72.82286106110875 135.60681893889125 UP 0.6 0.4 0.0 GO:0006950 3 response to stress 773 821 38 38 29 37 28 28 68 793 1658 0.29626 0.77682 0.57829 3.41 29142;365813;360243;78968;24950;84386;25664;54133;24614;338475;291234;316273;25211;25626;293502;24484;63868;24471;65030;25086;25599;114494;25612;25649;155423;65155;192272;170465 vnn1;trim59;top2a;srebf1;srd5a1;slpi;pparg;pdlim1;orm1;nrep;mki67;mcm3;lyz2;krt8;kif22;igfbp3;hspd1;hspb1;ephx2;cyp2e1;cd74;ccna2;asns;apoa2;anxa7;alas1;acot2;acaa2 VNN1_10157;TRIM59_10085;TOP2A_10059;SREBF1_32750;SRD5A1_32503;SLPI_9890;PPARG_32510;PDLIM1_9452;ORM1_9400;NREP_9364;MKI67_9232;MCM3_9207;LYZ2_32611;KRT8_8978;KIF22_8963;IGFBP3_8881;HSPD1_8849;HSPB1_8847;EPHX2_33282;CYP2E1_8421;CD74_8252;CCNA2_8221;ASNS_8091;APOA2_33095;ANXA7_8051;ALAS1_8018;ACOT2_7969;ACAA2_7955 25664(0.0441) 46.651538214285715 51.886250000000004 3.54778 24.18763200808277 49.34762947079957 24.60460957772919 31.001606428571428 33.442949999999996 1.51564 15.049636432702538 32.63362784841947 15.283709382786583 86.61625892857144 87.5632 8.55785 56.22884546702224 91.39539674163818 55.18988752072695 20.7328;56.1278;54.9577;41.2009;29.2087;53.7429;60.1903;67.1147;24.2519;69.4104;49.7822;54.0045;77.8257;68.9539;73.9175;50.946;34.4455;41.6322;6.44145;7.89174;94.9138;52.8265;28.1893;3.54778;64.7676;27.1843;13.6362;78.3988 16.8296;33.6269;18.8326;31.4864;22.9308;37.8192;43.9036;47.2419;19.7133;43.1468;35.6665;33.259;49.2403;45.3374;47.5608;36.3081;26.6907;30.9494;2.66377;4.16797;58.8146;37.3288;23.1774;1.51564;43.3787;21.5215;11.3249;43.6084 26.7838;121.883;218.525;60.0774;39.9852;92.543;101.057;123.914;31.358;157.944;82.1147;111.753;185.119;143.578;165.416;85.0816;48.4857;63.3196;17.3473;15.8079;118.773;90.0448;35.9474;8.55785;127.439;36.6615;16.9658;98.7727 16 12 16 29142;78968;25664;54133;24614;25626;63868;24471;65030;25086;25599;25612;25649;155423;65155;192272 VNN1_10157;SREBF1_32750;PPARG_32510;PDLIM1_9452;ORM1_9400;KRT8_8978;HSPD1_8849;HSPB1_8847;EPHX2_33282;CYP2E1_8421;CD74_8252;ASNS_8091;APOA2_33095;ANXA7_8051;ALAS1_8018;ACOT2_7969 37.818398125 31.3174 26.674388262604317 26.794798749999998 24.93405 17.430201452948225 61.004578124999995 42.5736 46.33431120632948 20.7328;41.2009;60.1903;67.1147;24.2519;68.9539;34.4455;41.6322;6.44145;7.89174;94.9138;28.1893;3.54778;64.7676;27.1843;13.6362 16.8296;31.4864;43.9036;47.2419;19.7133;45.3374;26.6907;30.9494;2.66377;4.16797;58.8146;23.1774;1.51564;43.3787;21.5215;11.3249 26.7838;60.0774;101.057;123.914;31.358;143.578;48.4857;63.3196;17.3473;15.8079;118.773;35.9474;8.55785;127.439;36.6615;16.9658 12 365813;360243;24950;84386;338475;291234;316273;25211;293502;24484;114494;170465 TRIM59_10085;TOP2A_10059;SRD5A1_32503;SLPI_9890;NREP_9364;MKI67_9232;MCM3_9207;LYZ2_32611;KIF22_8963;IGFBP3_8881;CCNA2_8221;ACAA2_7955 58.42905833333333 54.4811 14.1754179584659 36.610683333333334 36.81845 9.032248154034548 120.76516666666667 105.26285 51.055505331040244 56.1278;54.9577;29.2087;53.7429;69.4104;49.7822;54.0045;77.8257;73.9175;50.946;52.8265;78.3988 33.6269;18.8326;22.9308;37.8192;43.1468;35.6665;33.259;49.2403;47.5608;36.3081;37.3288;43.6084 121.883;218.525;39.9852;92.543;157.944;82.1147;111.753;185.119;165.416;85.0816;90.0448;98.7727 0 Exp 2,10(0.36);Exp 4,2(0.08);Hill,1(0.04);Linear,13(0.47);Poly 2,2(0.08) 2.0128939462381714 59.51210832595825 1.5239794254302979 4.608505725860596 0.8371577245091203 1.774873673915863 37.6923139407151 55.6107624878563 25.427143083369888 36.57606977377297 65.7888031026083 107.44371475453455 CONFLICT 0.5714285714285714 0.42857142857142855 0.0 GO:1901576 4 organic substance biosynthetic process 397 444 26 25 20 26 19 19 77 425 2026 0.77938 0.30684 0.49584 4.28 78968;24950;293820;298490;25664;313245;296371;362094;364975;25315;114027;25427;50549;29277;25599;25612;25649;65155;24763 srebf1;srd5a1;psat1;ppcs;pparg;polr1e;pltp;mrps2;gcdh;ephx1;dao;cyp51;cyp4a1;cyp2c11;cd74;asns;apoa2;alas1;acsm3 SREBF1_32750;SRD5A1_32503;PSAT1_9583;PPCS_9540;PPARG_32510;POLR1E_9523;PLTP_32412;MRPS2_9250;GCDH_8693;EPHX1_8567;DAO_8437;CYP51_8429;CYP4A1_33111;CYP2C11_32593;CD74_8252;ASNS_8091;APOA2_33095;ALAS1_8018;ACSM3_7976 25664(0.0441) 42.69685157894737 34.0134 3.54778 27.27411282316158 47.61962089167109 27.366512190195863 30.20857473684211 26.1579 1.51564 17.922735716874115 33.79012975724138 17.840888666392704 67.98586578947368 48.3681 8.55785 48.241137970996085 71.01975847055704 40.45495769683882 41.2009;29.2087;26.3316;15.1091;60.1903;73.982;87.0256;63.3158;15.9021;34.0134;6.1336;75.1522;23.208;54.426;94.9138;28.1893;3.54778;27.1843;52.2057 31.4864;22.9308;20.9188;7.94061;43.9036;47.589;56.6266;45.3429;10.4227;26.1579;2.43617;48.098;18.863;43.9518;58.8146;23.1774;1.51564;21.5215;42.2655 60.0774;39.9852;35.2954;30.6311;101.057;165.722;104.563;111.245;31.2818;48.3681;16.2027;171.379;29.9853;74.8861;118.773;35.9474;8.55785;36.6615;71.1126 17 2 17 78968;293820;298490;25664;313245;296371;362094;364975;25315;114027;50549;29277;25599;25612;25649;65155;24763 SREBF1_32750;PSAT1_9583;PPCS_9540;PPARG_32510;POLR1E_9523;PLTP_32412;MRPS2_9250;GCDH_8693;EPHX1_8567;DAO_8437;CYP4A1_33111;CYP2C11_32593;CD74_8252;ASNS_8091;APOA2_33095;ALAS1_8018;ACSM3_7976 41.58113411764707 34.0134 27.537869650688076 29.584359999999997 26.1579 18.37528692017046 63.55101470588235 48.3681 43.35983251557455 41.2009;26.3316;15.1091;60.1903;73.982;87.0256;63.3158;15.9021;34.0134;6.1336;23.208;54.426;94.9138;28.1893;3.54778;27.1843;52.2057 31.4864;20.9188;7.94061;43.9036;47.589;56.6266;45.3429;10.4227;26.1579;2.43617;18.863;43.9518;58.8146;23.1774;1.51564;21.5215;42.2655 60.0774;35.2954;30.6311;101.057;165.722;104.563;111.245;31.2818;48.3681;16.2027;29.9853;74.8861;118.773;35.9474;8.55785;36.6615;71.1126 2 24950;25427 SRD5A1_32503;CYP51_8429 52.18044999999999 52.18044999999999 32.48696040144416 35.5144 35.5144 17.795897783478058 105.68209999999999 105.68209999999999 92.909446985869 29.2087;75.1522 22.9308;48.098 39.9852;171.379 0 Exp 2,7(0.37);Hill,3(0.16);Linear,6(0.32);Poly 2,3(0.16) 1.934743660110007 37.79449439048767 1.5084086656570435 3.2609751224517822 0.5136012854939779 1.9018945693969727 30.4329147853189 54.960788372575834 22.149529904630683 38.267619569053515 46.29400469155418 89.67772688739318 UP 0.8947368421052632 0.10526315789473684 0.0 GO:0032535 5 regulation of cellular component size 54 60 3 3 2 3 2 2 94 58 2393 0.60424 0.66936 1.0 3.33 64159;155423 sptan1;anxa7 SPTAN1_9932;ANXA7_8051 56.15975 56.15975 47.5519 12.173338212873205 55.740144918097506 12.158866164058304 38.896950000000004 38.896950000000004 34.4152 6.338151633165573 38.678479060588124 6.330616638390342 102.03935 102.03935 76.6397 35.92052950952977 100.80119851983423 35.87782604993406 47.5519;64.7676 34.4152;43.3787 76.6397;127.439 2 0 2 64159;155423 SPTAN1_9932;ANXA7_8051 56.15975 56.15975 12.173338212873205 38.896950000000004 38.896950000000004 6.338151633165573 102.03935 102.03935 35.92052950952977 47.5519;64.7676 34.4152;43.3787 76.6397;127.439 0 0 Linear,2(1) 1.539672157963382 3.0800864696502686 1.5062377452850342 1.5738487243652344 0.04780818179027136 1.5400432348251343 39.288364 73.031136 30.112720000000003 47.681180000000005 52.256036000000016 151.82266399999997 UP 1.0 0.0 0.0 GO:0002683 5 negative regulation of immune system process 126 135 6 6 5 6 5 5 91 130 2321 0.59998 0.58352 1.0 3.7 309607;25664;102551184;25599;25649 rt1-ce5;pparg;loc102551184;cd74;apoa2 RT1-CE5_32445;PPARG_32510;HIST1H4A_32934;CD74_8252;APOA2_33095 25664(0.0441) 54.360555999999995 58.3303 3.54778 32.69732491643132 56.98036646334583 34.632989731428836 34.206168000000005 40.2068 1.51564 21.57716551582065 35.73055651677563 22.731146943945447 96.42277 105.902 8.55785 52.37651019841337 97.03588174260778 52.72063723576385 54.8206;60.1903;58.3303;94.9138;3.54778 26.5902;43.9036;40.2068;58.8146;1.51564 147.824;101.057;105.902;118.773;8.55785 3 2 3 25664;25599;25649 PPARG_32510;CD74_8252;APOA2_33095 52.88396 60.1903 46.11913221003621 34.74461333333333 43.9036 29.727226272232894 76.12928333333333 101.057 59.18520183323557 60.1903;94.9138;3.54778 43.9036;58.8146;1.51564 101.057;118.773;8.55785 2 309607;102551184 RT1-CE5_32445;HIST1H4A_32934 56.575450000000004 56.575450000000004 2.48173266993033 33.3985 33.3985 9.628390196704753 126.863 126.863 29.643330480902545 54.8206;58.3303 26.5902;40.2068 147.824;105.902 0 Exp 2,2(0.4);Hill,1(0.2);Linear,1(0.2);Poly 2,1(0.2) 1.6788808482115496 8.410922408103943 1.5239794254302979 1.8475407361984253 0.11792784288139219 1.6577342748641968 25.700087051349094 83.0210249486509 15.292948528785395 53.1193874712146 50.512734606677604 142.33280539332242 UP 0.6 0.4 0.0 GO:0044283 4 small molecule biosynthetic process 144 161 14 13 10 14 9 9 87 152 2299 0.92207 0.14906 0.19947 5.59 293820;296371;25315;25427;50549;29277;25599;25612;24763 psat1;pltp;ephx1;cyp51;cyp4a1;cyp2c11;cd74;asns;acsm3 PSAT1_9583;PLTP_32412;EPHX1_8567;CYP51_8429;CYP4A1_33111;CYP2C11_32593;CD74_8252;ASNS_8091;ACSM3_7976 52.82951111111111 52.2057 23.208 27.346067993380892 60.293591896002674 27.680130093529915 37.65262222222222 42.2655 18.863 15.623046845668236 42.34108115880032 15.284700090993356 76.7011 71.1126 29.9853 47.309065544697674 80.67060013308618 37.69780275005525 7.5 90.96969999999999 26.3316;87.0256;34.0134;75.1522;23.208;54.426;94.9138;28.1893;52.2057 20.9188;56.6266;26.1579;48.098;18.863;43.9518;58.8146;23.1774;42.2655 35.2954;104.563;48.3681;171.379;29.9853;74.8861;118.773;35.9474;71.1126 8 1 8 293820;296371;25315;50549;29277;25599;25612;24763 PSAT1_9583;PLTP_32412;EPHX1_8567;CYP4A1_33111;CYP2C11_32593;CD74_8252;ASNS_8091;ACSM3_7976 50.039175 43.10955 27.83078776528664 36.34695 34.2117 16.168278402035092 64.8663625 59.74035 33.425372355525624 26.3316;87.0256;34.0134;23.208;54.426;94.9138;28.1893;52.2057 20.9188;56.6266;26.1579;18.863;43.9518;58.8146;23.1774;42.2655 35.2954;104.563;48.3681;29.9853;74.8861;118.773;35.9474;71.1126 1 25427 CYP51_8429 75.1522 75.1522 48.098 48.098 171.379 171.379 75.1522 48.098 171.379 0 Exp 2,4(0.45);Linear,3(0.34);Poly 2,2(0.23) 2.177022869335447 20.28388822078705 1.5084086656570435 3.2609751224517822 0.6284138031670871 2.0425233840942383 34.96341335543559 70.69560886678663 27.445564949718975 47.85967949472548 45.79251051079754 107.60968948920248 UP 0.8888888888888888 0.1111111111111111 0.0 GO:0065009 3 regulation of molecular function 643 686 24 24 17 23 17 17 79 669 1782 0.02177 0.98855 0.045378 2.48 361604;84386;299270;24679;25664;24484;63868;24471;29455;299626;58868;64515;25599;362485;114494;25649;502970 sytl2;slpi;serpina6;prkar2b;pparg;igfbp3;hspd1;hspb1;gdf15;gadd45b;fzd1;cdc20;cd74;ccne2;ccna2;apoa2;angptl3 SYTL2_32351;SLPI_9890;SERPINA6_32325;PRKAR2B_33052;PPARG_32510;IGFBP3_8881;HSPD1_8849;HSPB1_8847;GDF15_33113;GADD45B_8679;FZD1_8671;CDC20_8255;CD74_8252;CCNE2_8227;CCNA2_8221;APOA2_33095;ANGPTL3_8045 25664(0.0441) 57.240257647058826 53.7429 3.54778 28.221671625676144 58.20491442281161 25.168031161761927 36.69223176470588 37.3288 1.51564 15.334366549368877 37.637202940056355 14.050699700445593 115.98822647058824 92.543 8.55785 97.1443309882551 111.98677790877296 86.795728916481 67.0093;53.7429;68.3847;108.746;60.1903;50.946;34.4455;41.6322;21.3654;52.5718;25.231;101.569;94.9138;77.8893;52.8265;3.54778;58.0729 44.4373;37.8192;36.9679;59.3814;43.9036;36.3081;26.6907;30.9494;17.8875;37.1918;13.6792;51.5499;58.8146;49.2672;37.3288;1.51564;40.0757 135.846;92.543;89.5095;147.467;101.057;85.0816;48.4857;63.3196;26.3528;89.36;131.659;453.17;118.773;185.461;90.0448;8.55785;105.112 11 6 11 299270;24679;25664;63868;24471;29455;299626;58868;25599;25649;502970 SERPINA6_32325;PRKAR2B_33052;PPARG_32510;HSPD1_8849;HSPB1_8847;GDF15_33113;GADD45B_8679;FZD1_8671;CD74_8252;APOA2_33095;ANGPTL3_8045 51.736489090909096 52.5718 31.38791623293443 33.368858181818176 36.9679 17.888831098281322 84.51395000000001 89.5095 43.594839608301136 68.3847;108.746;60.1903;34.4455;41.6322;21.3654;52.5718;25.231;94.9138;3.54778;58.0729 36.9679;59.3814;43.9036;26.6907;30.9494;17.8875;37.1918;13.6792;58.8146;1.51564;40.0757 89.5095;147.467;101.057;48.4857;63.3196;26.3528;89.36;131.659;118.773;8.55785;105.112 6 361604;84386;24484;64515;362485;114494 SYTL2_32351;SLPI_9890;IGFBP3_8881;CDC20_8255;CCNE2_8227;CCNA2_8221 67.3305 60.376099999999994 19.73477660952865 42.785083333333326 41.12825 6.602302716300374 173.69106666666667 114.1945 142.2059062154405 67.0093;53.7429;50.946;101.569;77.8893;52.8265 44.4373;37.8192;36.3081;51.5499;49.2672;37.3288 135.846;92.543;85.0816;453.17;185.461;90.0448 0 Exp 2,4(0.24);Hill,1(0.06);Linear,8(0.48);Poly 2,3(0.18);Power,1(0.06) 1.7831851634301712 31.92727506160736 1.512166976928711 5.015069484710693 0.8327383686685658 1.6557694673538208 43.82452654314395 70.6559887509737 29.40273662055454 43.981726908857205 69.80874284204143 162.16771009913504 UP 0.6470588235294118 0.35294117647058826 0.0 GO:0033762 6 response to glucagon 17 18 3 3 2 3 2 2 94 16 2435 0.97193 0.14569 0.14569 11.11 78968;114494 srebf1;ccna2 SREBF1_32750;CCNA2_8221 47.0137 47.0137 41.2009 8.22054059536228 44.70851378008494 7.546490619024674 34.4076 34.4076 31.4864 4.131200658404234 33.24913764354255 3.7924594681211867 75.0611 75.0611 60.0774 21.190151754529747 69.11900346075193 19.452647861319832 0.0 41.2009 0.5 47.0137 41.2009;52.8265 31.4864;37.3288 60.0774;90.0448 1 1 1 78968 SREBF1_32750 41.2009 41.2009 31.4864 31.4864 60.0774 60.0774 41.2009 31.4864 60.0774 1 114494 CCNA2_8221 52.8265 52.8265 37.3288 37.3288 90.0448 90.0448 52.8265 37.3288 90.0448 0 Exp 2,1(0.5);Linear,1(0.5) 2.1089891290779685 4.238153457641602 1.912555456161499 2.3255980014801025 0.2920651847133364 2.119076728820801 35.620611999999994 58.406788000000006 28.682048 40.133152 45.693048000000005 104.42915199999999 CONFLICT 0.5 0.5 0.0 GO:0051649 4 establishment of localization in cell 242 254 6 6 5 6 5 5 91 249 2202 0.070474 0.97051 0.12032 1.97 257644;293502;63868;24471;25599 zwint;kif22;hspd1;hspb1;cd74 ZWINT_10214;KIF22_8963;HSPD1_8849;HSPB1_8847;CD74_8252 60.79506 59.0663 34.4455 24.498928432953967 63.45651990904796 24.456438689783774 40.919039999999995 40.5797 26.6907 12.906573675185854 42.3531153319159 12.860745308400022 100.83646 108.188 48.4857 46.62187912073042 104.24477715863455 44.06070014442668 59.0663;73.9175;34.4455;41.6322;94.9138 40.5797;47.5608;26.6907;30.9494;58.8146 108.188;165.416;48.4857;63.3196;118.773 4 1 4 257644;63868;24471;25599 ZWINT_10214;HSPD1_8849;HSPB1_8847;CD74_8252 57.51445 50.34925 26.990998116717858 39.2586 35.76455 14.273254198675218 84.691575 85.7538 34.06489991045279 59.0663;34.4455;41.6322;94.9138 40.5797;26.6907;30.9494;58.8146 108.188;48.4857;63.3196;118.773 1 293502 KIF22_8963 73.9175 73.9175 47.5608 47.5608 165.416 165.416 73.9175 47.5608 165.416 0 Exp 2,1(0.2);Linear,3(0.6);Poly 2,1(0.2) 1.7424338509139135 8.749024152755737 1.5678966045379639 2.020775556564331 0.1825190393851294 1.6577342748641968 39.32080241402092 82.26931758597908 29.605929371024676 52.23215062897533 59.970581146529305 141.70233885347068 UP 0.8 0.2 0.0 GO:0010639 7 negative regulation of organelle organization 85 89 4 4 4 4 4 4 92 85 2366 0.75724 0.43442 0.57647 4.49 360243;64159;306575;170465 top2a;sptan1;ckap2;acaa2 TOP2A_10059;SPTAN1_9932;CKAP2_8324;ACAA2_7955 61.280375 59.5854 47.5519 13.292712231237841 64.80401777411598 12.300107399436763 34.992374999999996 38.764250000000004 18.8326 11.570894069280062 37.24622676583237 11.305303298182263 129.8436 112.10485 76.6397 62.39621952100409 130.413218989935 54.93026877042707 54.9577;47.5519;64.2131;78.3988 18.8326;34.4152;43.1133;43.6084 218.525;76.6397;125.437;98.7727 1 3 1 64159 SPTAN1_9932 47.5519 47.5519 34.4152 34.4152 76.6397 76.6397 47.5519 34.4152 76.6397 3 360243;306575;170465 TOP2A_10059;CKAP2_8324;ACAA2_7955 65.85653333333333 64.2131 11.806648429733725 35.18476666666667 43.1133 14.163555239534075 147.57823333333332 125.437 62.87152772888006 54.9577;64.2131;78.3988 18.8326;43.1133;43.6084 218.525;125.437;98.7727 0 Exp 2,1(0.25);Linear,2(0.5);Poly 2,1(0.25) 1.8760599643903229 7.67513906955719 1.5062377452850342 2.6341071128845215 0.49352957447879253 1.7673971056938171 48.253517013386926 74.30723298661307 23.652898812105562 46.33185118789444 68.69530486941599 190.99189513058403 DOWN 0.25 0.75 0.0 GO:0050708 6 regulation of protein secretion 128 139 7 7 6 7 6 6 90 133 2318 0.73227 0.42768 0.64739 4.32 78968;24614;63868;25427;65210;25649 srebf1;orm1;hspd1;cyp51;cyp2j4;apoa2 SREBF1_32750;ORM1_9400;HSPD1_8849;CYP51_8429;CYP2J4_32580;APOA2_33095 32.48562999999999 29.3487 3.54778 24.76650881213176 26.69681608011298 17.888543451100986 22.623639999999998 23.201999999999998 1.51564 16.76307039114255 19.119797417383488 13.622567484592937 59.450025000000004 42.66395 8.55785 57.513467227613305 44.098655566825 34.61843817779228 41.2009;24.2519;34.4455;75.1522;16.3155;3.54778 31.4864;19.7133;26.6907;48.098;8.2378;1.51564 60.0774;31.358;48.4857;171.379;36.8422;8.55785 5 1 5 78968;24614;63868;65210;25649 SREBF1_32750;ORM1_9400;HSPD1_8849;CYP2J4_32580;APOA2_33095 23.952315999999996 24.2519 14.852410233941164 17.528768 19.7133 12.512703782561147 37.064229999999995 36.8422 19.398969233235054 41.2009;24.2519;34.4455;16.3155;3.54778 31.4864;19.7133;26.6907;8.2378;1.51564 60.0774;31.358;48.4857;36.8422;8.55785 1 25427 CYP51_8429 75.1522 75.1522 48.098 48.098 171.379 171.379 75.1522 48.098 171.379 0 Exp 2,3(0.5);Exp 4,1(0.17);Hill,1(0.17);Linear,1(0.17) 1.9901107478138684 12.453641176223755 1.633623480796814 3.5849626064300537 0.7505546840225141 1.8194039463996887 12.668295628710464 52.302964371289534 9.210390132985685 36.03688986701432 13.429666638327795 105.47038336167219 UP 0.8333333333333334 0.16666666666666666 0.0 GO:0051049 5 regulation of transport 454 483 20 20 14 20 14 14 82 469 1982 0.16275 0.89727 0.29111 2.9 361604;78968;309607;25664;296371;24614;24484;63868;25427;65210;25599;25649;170465;114628 sytl2;srebf1;rt1-ce5;pparg;pltp;orm1;igfbp3;hspd1;cyp51;cyp2j4;cd74;apoa2;acaa2;abcg5 SYTL2_32351;SREBF1_32750;RT1-CE5_32445;PPARG_32510;PLTP_32412;ORM1_9400;IGFBP3_8881;HSPD1_8849;CYP51_8429;CYP2J4_32580;CD74_8252;APOA2_33095;ACAA2_7955;ABCG5_7947 25664(0.0441) 51.52357714285714 52.8833 3.54778 27.417086980055522 50.13869083980138 27.74874874108445 33.58860285714285 33.89725 1.51564 17.012010084465643 32.834431555875476 17.24810474093576 85.64645357142857 91.92715 8.55785 48.15667861014658 79.78578682346438 43.562230633131165 67.0093;41.2009;54.8206;60.1903;87.0256;24.2519;50.946;34.4455;75.1522;16.3155;94.9138;3.54778;78.3988;33.1119 44.4373;31.4864;26.5902;43.9036;56.6266;19.7133;36.3081;26.6907;48.098;8.2378;58.8146;1.51564;43.6084;24.2098 135.846;60.0774;147.824;101.057;104.563;31.358;85.0816;48.4857;171.379;36.8422;118.773;8.55785;98.7727;50.4329 8 6 8 78968;25664;296371;24614;63868;65210;25599;25649 SREBF1_32750;PPARG_32510;PLTP_32412;ORM1_9400;HSPD1_8849;CYP2J4_32580;CD74_8252;APOA2_33095 45.23641 37.8232 32.91816248611005 30.873579999999997 29.088549999999998 21.14707382438661 63.71426875 54.281549999999996 39.91234174490514 41.2009;60.1903;87.0256;24.2519;34.4455;16.3155;94.9138;3.54778 31.4864;43.9036;56.6266;19.7133;26.6907;8.2378;58.8146;1.51564 60.0774;101.057;104.563;31.358;48.4857;36.8422;118.773;8.55785 6 361604;309607;24484;25427;170465;114628 SYTL2_32351;RT1-CE5_32445;IGFBP3_8881;CYP51_8429;ACAA2_7955;ABCG5_7947 59.90646666666666 60.91495 17.023241899434648 37.20863333333333 39.95825000000001 9.943044768413067 114.88936666666667 117.30935 44.76122255000039 67.0093;54.8206;50.946;75.1522;78.3988;33.1119 44.4373;26.5902;36.3081;48.098;43.6084;24.2098 135.846;147.824;85.0816;171.379;98.7727;50.4329 0 Exp 2,6(0.43);Exp 4,1(0.08);Hill,1(0.08);Linear,3(0.22);Poly 2,3(0.22) 1.8382603529478079 26.502145171165466 1.5084086656570435 3.5849626064300537 0.5521001852347807 1.7274702787399292 37.16162869967236 65.88552558604191 24.677167009644954 42.500038704640765 60.42044265724708 110.87246448561008 CONFLICT 0.5714285714285714 0.42857142857142855 0.0 GO:0019724 6 B cell mediated immunity 12 14 2 2 2 2 2 2 94 12 2439 0.98604 0.095353 0.095353 14.29 63868;25599 hspd1;cd74 HSPD1_8849;CD74_8252 64.67965 64.67965 34.4455 42.757544976822516 70.4132513503542 41.98165413076803 42.75265 42.75265 26.6907 22.715027528158515 45.7986366809327 22.302834032565496 83.62935 83.62935 48.4857 49.7006264612932 90.29398846664701 48.79874443940924 0.0 34.4455 0.5 64.67965 34.4455;94.9138 26.6907;58.8146 48.4857;118.773 2 0 2 63868;25599 HSPD1_8849;CD74_8252 64.67965 64.67965 42.757544976822516 42.75265 42.75265 22.715027528158515 83.62935 83.62935 49.7006264612932 34.4455;94.9138 26.6907;58.8146 48.4857;118.773 0 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.656751579841125 3.3135037422180176 1.6557694673538208 1.6577342748641968 0.0013893287143131108 1.6567518711090088 5.420716000000013 123.93858399999998 11.271228000000008 74.234072 14.747796000000008 152.51090399999998 UP 1.0 0.0 0.0 GO:0035337 8 fatty-acyl-CoA metabolic process 4 6 1 1 1 1 1 1 95 5 2446 0.9809 0.20606 0.20606 16.67 364975 gcdh GCDH_8693 15.9021 15.9021 15.9021 15.902099999999999 10.4227 10.4227 10.4227 10.4227 31.2818 31.2818 31.2818 31.281800000000004 0.0 15.9021 0.0 15.9021 15.9021 10.4227 31.2818 1 0 1 364975 GCDH_8693 15.9021 15.9021 10.4227 10.4227 31.2818 31.2818 15.9021 10.4227 31.2818 0 0 Poly 2,1(1) 1.5464483499526978 1.5464483499526978 1.5464483499526978 1.5464483499526978 0.0 1.5464483499526978 15.9021 15.9021 10.4227 10.4227 31.2818 31.2818 UP 1.0 0.0 0.0 GO:0046949 8 fatty-acyl-CoA biosynthetic process 4 6 1 1 1 1 1 1 95 5 2446 0.9809 0.20606 0.20606 16.67 364975 gcdh GCDH_8693 15.9021 15.9021 15.9021 15.902099999999999 10.4227 10.4227 10.4227 10.4227 31.2818 31.2818 31.2818 31.281800000000004 0.0 15.9021 0.0 15.9021 15.9021 10.4227 31.2818 1 0 1 364975 GCDH_8693 15.9021 15.9021 10.4227 10.4227 31.2818 31.2818 15.9021 10.4227 31.2818 0 0 Poly 2,1(1) 1.5464483499526978 1.5464483499526978 1.5464483499526978 1.5464483499526978 0.0 1.5464483499526978 15.9021 15.9021 10.4227 10.4227 31.2818 31.2818 UP 1.0 0.0 0.0 GO:0060255 5 regulation of macromolecule metabolic process 1000 1070 41 40 30 40 29 29 67 1041 1410 0.010332 0.99435 0.019977 2.71 360243;78968;84386;299270;309607;24679;25664;363465;54133;24614;65035;259241;24484;63868;24471;29455;299626;58868;65030;25427;65210;306575;64515;25599;362485;114494;25649;155423;81633 top2a;srebf1;slpi;serpina6;rt1-ce5;prkar2b;pparg;pir;pdlim1;orm1;nr1i3;nr1d2;igfbp3;hspd1;hspb1;gdf15;gadd45b;fzd1;ephx2;cyp51;cyp2j4;ckap2;cdc20;cd74;ccne2;ccna2;apoa2;anxa7;acta2 TOP2A_10059;SREBF1_32750;SLPI_9890;SERPINA6_32325;RT1-CE5_32445;PRKAR2B_33052;PPARG_32510;PIR_9487;PDLIM1_9452;ORM1_9400;NR1I3_32602;NR1D2_9358;IGFBP3_8881;HSPD1_8849;HSPB1_8847;GDF15_33113;GADD45B_8679;FZD1_8671;EPHX2_33282;CYP51_8429;CYP2J4_32580;CKAP2_8324;CDC20_8255;CD74_8252;CCNE2_8227;CCNA2_8221;APOA2_33095;ANXA7_8051;ACTA2_33040 25664(0.0441) 54.51285275862069 53.7429 3.54778 28.454569173001882 52.094617831974084 27.106503500535798 34.32246586206897 37.1918 1.51564 17.220010188729677 33.423926841428006 17.03557709820866 107.86773620689657 92.543 8.55785 83.52891484816467 99.3333072347714 76.94733033977624 54.9577;41.2009;53.7429;68.3847;54.8206;108.746;60.1903;52.1607;67.1147;24.2519;22.095;99.0234;50.946;34.4455;41.6322;21.3654;52.5718;25.231;6.44145;75.1522;16.3155;64.2131;101.569;94.9138;77.8893;52.8265;3.54778;64.7676;90.3558 18.8326;31.4864;37.8192;36.9679;26.5902;59.3814;43.9036;40.9644;47.2419;19.7133;12.9529;42.5557;36.3081;26.6907;30.9494;17.8875;37.1918;13.6792;2.66377;48.098;8.2378;43.1133;51.5499;58.8146;49.2672;37.3288;1.51564;43.3787;70.2676 218.525;60.0774;92.543;89.5095;147.824;147.467;101.057;74.9097;123.914;31.358;55.8619;102.838;85.0816;48.4857;63.3196;26.3528;89.36;131.659;17.3473;171.379;36.8422;125.437;453.17;118.773;185.461;90.0448;8.55785;127.439;103.57 19 10 19 78968;299270;24679;25664;363465;54133;24614;65035;259241;63868;24471;29455;299626;58868;65030;65210;25599;25649;155423 SREBF1_32750;SERPINA6_32325;PRKAR2B_33052;PPARG_32510;PIR_9487;PDLIM1_9452;ORM1_9400;NR1I3_32602;NR1D2_9358;HSPD1_8849;HSPB1_8847;GDF15_33113;GADD45B_8679;FZD1_8671;EPHX2_33282;CYP2J4_32580;CD74_8252;APOA2_33095;ANXA7_8051 47.59998052631579 41.6322 30.894620799046425 30.325084736842104 31.4864 17.63053665173341 76.58573421052633 74.9097 42.319601515800244 41.2009;68.3847;108.746;60.1903;52.1607;67.1147;24.2519;22.095;99.0234;34.4455;41.6322;21.3654;52.5718;25.231;6.44145;16.3155;94.9138;3.54778;64.7676 31.4864;36.9679;59.3814;43.9036;40.9644;47.2419;19.7133;12.9529;42.5557;26.6907;30.9494;17.8875;37.1918;13.6792;2.66377;8.2378;58.8146;1.51564;43.3787 60.0774;89.5095;147.467;101.057;74.9097;123.914;31.358;55.8619;102.838;48.4857;63.3196;26.3528;89.36;131.659;17.3473;36.8422;118.773;8.55785;127.439 10 360243;84386;309607;24484;25427;306575;64515;362485;114494;81633 TOP2A_10059;SLPI_9890;RT1-CE5_32445;IGFBP3_8881;CYP51_8429;CKAP2_8324;CDC20_8255;CCNE2_8227;CCNA2_8221;ACTA2_33040 67.64730999999999 59.5854 17.816489165093394 41.91749 40.46625 14.249032091841661 167.30354000000003 136.6305 110.15256898264332 54.9577;53.7429;54.8206;50.946;75.1522;64.2131;101.569;77.8893;52.8265;90.3558 18.8326;37.8192;26.5902;36.3081;48.098;43.1133;51.5499;49.2672;37.3288;70.2676 218.525;92.543;147.824;85.0816;171.379;125.437;453.17;185.461;90.0448;103.57 0 Exp 2,10(0.35);Exp 4,2(0.07);Hill,1(0.04);Linear,9(0.32);Poly 2,5(0.18);Power,2(0.07) 1.9168461634993046 58.070618867874146 1.5124053955078125 5.015069484710693 0.7363743783910229 1.7380040884017944 44.156446301905405 64.86925921533597 28.05502165586842 40.58991006826949 77.46631322992401 138.26915918386908 UP 0.6551724137931034 0.3448275862068966 0.0 GO:0050790 4 regulation of catalytic activity 528 565 22 22 16 21 16 16 80 549 1902 0.11268 0.93055 0.21108 2.83 361604;84386;299270;24679;25664;24484;63868;24471;29455;299626;64515;25599;362485;114494;25649;502970 sytl2;slpi;serpina6;prkar2b;pparg;igfbp3;hspd1;hspb1;gdf15;gadd45b;cdc20;cd74;ccne2;ccna2;apoa2;angptl3 SYTL2_32351;SLPI_9890;SERPINA6_32325;PRKAR2B_33052;PPARG_32510;IGFBP3_8881;HSPD1_8849;HSPB1_8847;GDF15_33113;GADD45B_8679;CDC20_8255;CD74_8252;CCNE2_8227;CCNA2_8221;APOA2_33095;ANGPTL3_8045 25664(0.0441) 59.24083625 55.9079 3.54778 27.874449924018677 59.75274145898388 24.673230496369484 38.130546249999995 37.574 1.51564 14.604988078473681 38.76181448019123 13.319577664485529 115.00880312500001 91.29390000000001 8.55785 100.24350859317269 111.06334501500278 88.86940683443129 67.0093;53.7429;68.3847;108.746;60.1903;50.946;34.4455;41.6322;21.3654;52.5718;101.569;94.9138;77.8893;52.8265;3.54778;58.0729 44.4373;37.8192;36.9679;59.3814;43.9036;36.3081;26.6907;30.9494;17.8875;37.1918;51.5499;58.8146;49.2672;37.3288;1.51564;40.0757 135.846;92.543;89.5095;147.467;101.057;85.0816;48.4857;63.3196;26.3528;89.36;453.17;118.773;185.461;90.0448;8.55785;105.112 10 6 10 299270;24679;25664;63868;24471;29455;299626;25599;25649;502970 SERPINA6_32325;PRKAR2B_33052;PPARG_32510;HSPD1_8849;HSPB1_8847;GDF15_33113;GADD45B_8679;CD74_8252;APOA2_33095;ANGPTL3_8045 54.387038 55.32235 31.761643197266107 35.337824 37.07985 17.555157132053633 79.799445 89.43475000000001 42.89545312770761 68.3847;108.746;60.1903;34.4455;41.6322;21.3654;52.5718;94.9138;3.54778;58.0729 36.9679;59.3814;43.9036;26.6907;30.9494;17.8875;37.1918;58.8146;1.51564;40.0757 89.5095;147.467;101.057;48.4857;63.3196;26.3528;89.36;118.773;8.55785;105.112 6 361604;84386;24484;64515;362485;114494 SYTL2_32351;SLPI_9890;IGFBP3_8881;CDC20_8255;CCNE2_8227;CCNA2_8221 67.3305 60.376099999999994 19.73477660952865 42.785083333333326 41.12825 6.602302716300374 173.69106666666667 114.1945 142.2059062154405 67.0093;53.7429;50.946;101.569;77.8893;52.8265 44.4373;37.8192;36.3081;51.5499;49.2672;37.3288 135.846;92.543;85.0816;453.17;185.461;90.0448 0 Exp 2,4(0.25);Hill,1(0.07);Linear,8(0.5);Poly 2,2(0.13);Power,1(0.07) 1.801635604999102 30.41486966609955 1.512166976928711 5.015069484710693 0.8545244153621742 1.6567518711090088 45.58235578723085 72.89931671276915 30.9741020915479 45.286990408452105 65.88948391434536 164.1281223356546 UP 0.625 0.375 0.0 GO:1903901 6 negative regulation of viral life cycle 23 24 2 2 2 2 2 2 94 22 2429 0.94078 0.22823 0.22823 8.33 365813;84386 trim59;slpi TRIM59_10085;SLPI_9890 54.93535 54.93535 53.7429 1.6863789624516887 54.78727377496588 1.6733262886114926 35.72305 35.72305 33.6269 2.964403758768402 35.983346011661084 2.941459096711489 107.213 107.213 92.543 20.746512960013373 105.3913066617045 20.58593371121217 0.5 54.93535 56.1278;53.7429 33.6269;37.8192 121.883;92.543 0 2 0 2 365813;84386 TRIM59_10085;SLPI_9890 54.93535 54.93535 1.6863789624516887 35.72305 35.72305 2.964403758768402 107.213 107.213 20.746512960013373 56.1278;53.7429 33.6269;37.8192 121.883;92.543 0 Exp 2,1(0.5);Linear,1(0.5) 1.6187785309378926 3.24285089969635 1.528815746307373 1.714035153388977 0.13096989875475384 1.621425449848175 52.598147999999995 57.272552000000005 31.614596 39.831504 78.4598 135.9662 DOWN 0.0 1.0 0.0 GO:0009314 4 response to radiation 159 166 8 8 4 8 4 4 92 162 2289 0.23762 0.88345 0.52368 2.41 360243;25664;25612;114628 top2a;pparg;asns;abcg5 TOP2A_10059;PPARG_32510;ASNS_8091;ABCG5_7947 25664(0.0441) 44.1123 44.034800000000004 28.1893 15.818507244364124 45.99790407648494 15.543651529748898 27.530849999999997 23.6936 18.8326 11.16106917862264 29.906553547599675 11.986367011435084 101.490575 75.74495 35.9474 82.86543024254746 97.76727972335232 72.88295908669747 54.9577;60.1903;28.1893;33.1119 18.8326;43.9036;23.1774;24.2098 218.525;101.057;35.9474;50.4329 2 2 2 25664;25612 PPARG_32510;ASNS_8091 44.1898 44.1898 22.628124104750704 33.540499999999994 33.540499999999994 14.655636568228635 68.5022 68.5022 46.03943968034364 60.1903;28.1893 43.9036;23.1774 101.057;35.9474 2 360243;114628 TOP2A_10059;ABCG5_7947 44.034800000000004 44.034800000000004 15.447313320445058 21.5212 21.5212 3.8022545837962927 134.47895 134.47895 118.85906377388726 54.9577;33.1119 18.8326;24.2098 218.525;50.4329 0 Exp 2,4(1) 2.183396463628472 9.123042345046997 1.5239794254302979 3.2609751224517822 0.7793046481671604 2.1690438985824585 28.610162900523164 59.61443709947683 16.593002204949823 38.468697795050176 20.2824533623035 182.69869663769651 CONFLICT 0.5 0.5 0.0 GO:0030300 8 regulation of intestinal cholesterol absorption 5 5 3 3 2 3 2 2 94 3 2448 0.99951 0.013053 0.013053 40.0 25649;114628 apoa2;abcg5 APOA2_33095;ABCG5_7947 18.32984 18.32984 3.54778 20.904989731812833 20.7144416166539 20.6311886702367 12.862720000000001 12.862720000000001 1.51564 16.0471944293325 14.693200008354802 15.83701786735201 29.495375 29.495375 8.55785 29.610131817525737 32.872959447886934 29.222316007565766 0.0 3.54778 0.0 3.54778 3.54778;33.1119 1.51564;24.2098 8.55785;50.4329 1 1 1 25649 APOA2_33095 3.54778 3.54778 1.51564 1.51564 8.55785 8.55785 3.54778 1.51564 8.55785 1 114628 ABCG5_7947 33.1119 33.1119 24.2098 24.2098 50.4329 50.4329 33.1119 24.2098 50.4329 0 Exp 2,1(0.5);Hill,1(0.5) 2.0906553017114122 4.258234143257141 1.7262524366378784 2.5319817066192627 0.5697366306043233 2.1291170716285706 -10.642997599999994 47.302677599999996 -9.377556799999997 35.1029968 -11.542173999999996 70.53292399999998 CONFLICT 0.5 0.5 0.0 GO:0045582 9 positive regulation of T cell differentiation 34 35 2 2 2 2 2 2 94 33 2418 0.85695 0.38281 0.38281 5.71 29142;25599 vnn1;cd74 VNN1_10157;CD74_8252 57.823299999999996 57.823299999999996 20.7328 52.45388813519929 78.36320102158828 43.676484663337 37.8221 37.8221 16.8296 29.687878208117194 49.44728359676176 24.72003893975822 72.7784 72.7784 26.7838 65.04618711592555 98.24919525828835 54.16164358788155 0.5 57.823299999999996 20.7328;94.9138 16.8296;58.8146 26.7838;118.773 2 0 2 29142;25599 VNN1_10157;CD74_8252 57.823299999999996 57.823299999999996 52.45388813519929 37.8221 37.8221 29.687878208117194 72.7784 72.7784 65.04618711592555 20.7328;94.9138 16.8296;58.8146 26.7838;118.773 0 0 Linear,1(0.5);Poly 2,1(0.5) 2.763996725335798 6.2662400007247925 1.6577342748641968 4.608505725860596 2.086510502731222 3.1331200003623962 -14.874079999999978 130.52067999999997 -3.323199999999993 78.9674 -17.371015999999997 162.927816 UP 1.0 0.0 0.0 GO:0048583 4 regulation of response to stimulus 781 832 27 27 20 26 20 20 76 812 1639 0.0065134 0.99678 0.0107 2.4 29142;365813;84386;309607;24679;25664;338475;259241;24484;25685;63868;24471;29455;299626;58868;65210;25599;25649;81633;170465 vnn1;trim59;slpi;rt1-ce5;prkar2b;pparg;nrep;nr1d2;igfbp3;igfbp1;hspd1;hspb1;gdf15;gadd45b;fzd1;cyp2j4;cd74;apoa2;acta2;acaa2 VNN1_10157;TRIM59_10085;SLPI_9890;RT1-CE5_32445;PRKAR2B_33052;PPARG_32510;NREP_9364;NR1D2_9358;IGFBP3_8881;IGFBP1_32306;HSPD1_8849;HSPB1_8847;GDF15_33113;GADD45B_8679;FZD1_8671;CYP2J4_32580;CD74_8252;APOA2_33095;ACTA2_33040;ACAA2_7955 25664(0.0441) 56.567744000000005 54.28175 3.54778 31.02326552755262 55.57250987004594 28.05067224150279 35.316607 36.74995 1.51564 18.160518361154296 35.251538446664696 17.485753302011744 103.32616250000001 99.91485 8.55785 73.74156043190524 96.6322346138059 51.40858131387361 20.7328;56.1278;53.7429;54.8206;108.746;60.1903;69.4104;99.0234;50.946;98.8371;34.4455;41.6322;21.3654;52.5718;25.231;16.3155;94.9138;3.54778;90.3558;78.3988 16.8296;33.6269;37.8192;26.5902;59.3814;43.9036;43.1468;42.5557;36.3081;57.328;26.6907;30.9494;17.8875;37.1918;13.6792;8.2378;58.8146;1.51564;70.2676;43.6084 26.7838;121.883;92.543;147.824;147.467;101.057;157.944;102.838;85.0816;357.409;48.4857;63.3196;26.3528;89.36;131.659;36.8422;118.773;8.55785;103.57;98.7727 13 7 13 29142;24679;25664;259241;25685;63868;24471;29455;299626;58868;65210;25599;25649 VNN1_10157;PRKAR2B_33052;PPARG_32510;NR1D2_9358;IGFBP1_32306;HSPD1_8849;HSPB1_8847;GDF15_33113;GADD45B_8679;FZD1_8671;CYP2J4_32580;CD74_8252;APOA2_33095 52.11942923076923 41.6322 36.745961411395605 31.92038 30.9494 19.74514387489238 96.83884230769232 89.36 89.90456592778868 20.7328;108.746;60.1903;99.0234;98.8371;34.4455;41.6322;21.3654;52.5718;25.231;16.3155;94.9138;3.54778 16.8296;59.3814;43.9036;42.5557;57.328;26.6907;30.9494;17.8875;37.1918;13.6792;8.2378;58.8146;1.51564 26.7838;147.467;101.057;102.838;357.409;48.4857;63.3196;26.3528;89.36;131.659;36.8422;118.773;8.55785 7 365813;84386;309607;338475;24484;81633;170465 TRIM59_10085;SLPI_9890;RT1-CE5_32445;NREP_9364;IGFBP3_8881;ACTA2_33040;ACAA2_7955 64.8289 56.1278 14.99035506795397 41.62388571428572 37.8192 13.90093900166804 115.37404285714284 103.57 28.170303860144344 56.1278;53.7429;54.8206;69.4104;50.946;90.3558;78.3988 33.6269;37.8192;26.5902;43.1468;36.3081;70.2676;43.6084 121.883;92.543;147.824;157.944;85.0816;103.57;98.7727 0 Exp 2,6(0.3);Exp 4,1(0.05);Hill,1(0.05);Linear,6(0.3);Poly 2,4(0.2);Power,2(0.1) 1.9528026464936965 41.791704297065735 1.5124053955078125 5.015069484710693 0.9756104378226284 1.7274702787399292 42.97119840168783 70.16428959831218 27.357408901813873 43.27580509818611 71.00749868904083 135.6448263109592 UP 0.65 0.35 0.0 GO:0000819 5 sister chromatid segregation 14 14 3 3 3 3 3 3 93 11 2440 0.99858 0.013961 0.013961 21.43 257644;360243;303575 zwint;top2a;kif18b ZWINT_10214;TOP2A_10059;KIF18B_32882 60.002100000000006 59.0663 54.9577 5.5715565616799205 61.070352894229885 5.399739431511317 34.45583333333334 40.5797 18.8326 13.634975794013464 37.37620021557655 11.915212968528254 152.881 131.93 108.188 58.07556881340032 141.4263509769746 50.618804002370744 0.0 54.9577 0.5 57.012 59.0663;54.9577;65.9823 40.5797;18.8326;43.9552 108.188;218.525;131.93 1 2 1 257644 ZWINT_10214 59.0663 59.0663 40.5797 40.5797 108.188 108.188 59.0663 40.5797 108.188 2 360243;303575 TOP2A_10059;KIF18B_32882 60.47 60.47 7.795569419869182 31.3939 31.3939 17.76436082103715 175.22750000000002 175.22750000000002 61.23191171684904 54.9577;65.9823 18.8326;43.9552 218.525;131.93 0 Exp 2,1(0.34);Linear,2(0.67) 1.6961632307146235 5.097228765487671 1.5678966045379639 1.8061060905456543 0.1209270440727003 1.7232260704040527 53.69729022584525 66.30690977415475 19.026405721000614 49.88526094566605 87.16230723599563 218.59969276400437 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0006325 5 chromatin organization 88 101 3 3 2 3 2 2 94 99 2352 0.2564 0.90234 0.58817 1.98 102551184;114494 loc102551184;ccna2 HIST1H4A_32934;CCNA2_8221 55.5784 55.5784 52.8265 3.8917743022944653 54.291934123947975 3.4403369485425075 38.7678 38.7678 37.3288 2.035053316254796 38.095092272379496 1.798991558179027 97.9734 97.9734 90.0448 11.21273365063127 94.26691599081867 9.912080936885335 58.3303;52.8265 40.2068;37.3288 105.902;90.0448 0 2 0 2 102551184;114494 HIST1H4A_32934;CCNA2_8221 55.5784 55.5784 3.8917743022944653 38.7678 38.7678 2.035053316254796 97.9734 97.9734 11.21273365063127 58.3303;52.8265 40.2068;37.3288 105.902;90.0448 0 Linear,2(1) 1.9620986366012947 3.981013536453247 1.6554155349731445 2.3255980014801025 0.4738905666993963 1.9905067682266235 50.184676 60.972124 35.94736 41.58824 82.43334399999999 113.513456 DOWN 0.0 1.0 0.0 GO:0005975 4 carbohydrate metabolic process 100 118 3 3 3 3 3 3 93 115 2336 0.34059 0.83244 0.62442 2.54 286954;25685;502970 ugt2b1;igfbp1;angptl3 UGT2B10_33303,UGT2B1_33224;IGFBP1_32306;ANGPTL3_8045 56.484716666666664 58.0729 12.54415 43.16839178902585 47.16990192808138 32.4421516923393 34.917315 40.0757 7.348245 25.38603315449609 31.127913057724154 20.936672661121666 162.67228333333333 105.112 25.495849999999997 173.28148905405575 102.7254614028862 108.86224297209696 12.54415;98.8371;58.0729 7.348245;57.328;40.0757 25.495849999999997;357.409;105.112 4 0 3 286954;25685;502970 UGT2B10_33303,UGT2B1_33224;IGFBP1_32306;ANGPTL3_8045 56.484716666666664 58.0729 43.16839178902585 34.917315 40.0757 25.38603315449609 162.67228333333333 105.112 173.28148905405575 12.54415;98.8371;58.0729 7.348245;57.328;40.0757 25.495849999999997;357.409;105.112 0 0 Exp 4,1(0.25);Linear,2(0.5);Poly 2,1(0.25) 1.724198232972849 6.934645652770996 1.5375925302505493 2.031935214996338 0.21377721753942333 1.6825589537620544 7.635082731707158 105.33435060162618 6.190314172206033 63.644315827793974 -33.414180794505654 358.75874746117233 UP 1.0 0.0 0.0 GO:0006711 6 estrogen catabolic process 1 2 1 1 1 1 1 1 95 1 2450 0.99859 0.073976 0.073976 50.0 360268 sult1e1 SULT1E1_32446 59.2729 59.2729 59.2729 59.2729 45.3114 45.3114 45.3114 45.3114 91.5578 91.5578 91.5578 91.5578 0.0 59.2729 0.0 59.2729 59.2729 45.3114 91.5578 1 0 1 360268 SULT1E1_32446 59.2729 59.2729 45.3114 45.3114 91.5578 91.5578 59.2729 45.3114 91.5578 0 0 Exp 2,1(1) 2.945583581924439 2.9455835819244385 2.9455835819244385 2.9455835819244385 0.0 2.9455835819244385 59.2729 59.2729 45.3114 45.3114 91.5578 91.5578 UP 1.0 0.0 0.0 GO:0009605 3 response to external stimulus 571 616 31 30 24 29 22 22 74 594 1857 0.43827 0.65575 0.90328 3.57 29142;286954;365813;78968;24950;84386;25664;24614;315994;25211;25626;24484;63868;24471;58868;25086;25612;65155;81633;192272;114628;140668 vnn1;ugt2b1;trim59;srebf1;srd5a1;slpi;pparg;orm1;mapkapk3;lyz2;krt8;igfbp3;hspd1;hspb1;fzd1;cyp2e1;asns;alas1;acta2;acot2;abcg5;abcc3 VNN1_10157;UGT2B10_33303,UGT2B1_33224;TRIM59_10085;SREBF1_32750;SRD5A1_32503;SLPI_9890;PPARG_32510;ORM1_9400;MAPKAPK3_9194;LYZ2_32611;KRT8_8978;IGFBP3_8881;HSPD1_8849;HSPB1_8847;FZD1_8671;CYP2E1_8421;ASNS_8091;ALAS1_8018;ACTA2_33040;ACOT2_7969;ABCG5_7947;ABCC3_7941 25664(0.0441) 42.562431363636364 34.61150000000001 7.89174 25.452639516595056 45.883818061286085 25.682273179066108 29.834327954545458 26.67345 4.16797 16.45537831527421 31.786223774425356 16.190290781321014 86.3894159090909 55.25515 15.8079 90.22520103498877 95.22249963407992 94.67716308605029 20.7328;12.54415;56.1278;41.2009;29.2087;53.7429;60.1903;24.2519;104.193;77.8257;68.9539;50.946;34.4455;41.6322;25.231;7.89174;28.1893;27.1843;90.3558;13.6362;33.1119;34.7775 16.8296;7.348245;33.6269;31.4864;22.9308;37.8192;43.9036;19.7133;59.1667;49.2403;45.3374;36.3081;26.6907;30.9494;13.6792;4.16797;23.1774;21.5215;70.2676;11.3249;24.2098;26.6562 26.7838;25.495849999999997;121.883;60.0774;39.9852;92.543;101.057;31.358;434.985;185.119;143.578;85.0816;48.4857;63.3196;131.659;15.8079;35.9474;36.6615;103.57;16.9658;50.4329;49.7705 15 8 14 29142;286954;78968;25664;24614;25626;63868;24471;58868;25086;25612;65155;192272;140668 VNN1_10157;UGT2B10_33303,UGT2B1_33224;SREBF1_32750;PPARG_32510;ORM1_9400;KRT8_8978;HSPD1_8849;HSPB1_8847;FZD1_8671;CYP2E1_8421;ASNS_8091;ALAS1_8018;ACOT2_7969;ABCC3_7941 31.49012071428572 27.686799999999998 17.354354227211843 23.056129642857144 22.349449999999997 12.31627616569486 56.2119607142857 42.5736 41.03998372653084 20.7328;12.54415;41.2009;60.1903;24.2519;68.9539;34.4455;41.6322;25.231;7.89174;28.1893;27.1843;13.6362;34.7775 16.8296;7.348245;31.4864;43.9036;19.7133;45.3374;26.6907;30.9494;13.6792;4.16797;23.1774;21.5215;11.3249;26.6562 26.7838;25.495849999999997;60.0774;101.057;31.358;143.578;48.4857;63.3196;131.659;15.8079;35.9474;36.6615;16.9658;49.7705 8 365813;24950;84386;315994;25211;24484;81633;114628 TRIM59_10085;SRD5A1_32503;SLPI_9890;MAPKAPK3_9194;LYZ2_32611;IGFBP3_8881;ACTA2_33040;ABCG5_7947 61.938975 54.93535 26.644132715893427 41.696175000000004 37.06365 16.67139332695809 139.1999625 98.0565 127.6130018140778 56.1278;29.2087;53.7429;104.193;77.8257;50.946;90.3558;33.1119 33.6269;22.9308;37.8192;59.1667;49.2403;36.3081;70.2676;24.2098 121.883;39.9852;92.543;434.985;185.119;85.0816;103.57;50.4329 0 Exp 2,7(0.31);Exp 4,2(0.09);Linear,11(0.48);Poly 2,3(0.14) 1.9940883234296425 49.02931559085846 1.5124053955078125 4.608505725860596 0.928740100812618 1.7380040884017944 31.92645024660117 53.19841248067157 22.958063002896136 36.710592906194776 48.68670402087332 124.0921277973085 UP 0.6363636363636364 0.36363636363636365 0.0 GO:0045944 9 positive regulation of transcription by RNA polymerase II 241 260 8 8 6 8 6 6 90 254 2197 0.12483 0.93881 0.23008 2.31 360243;78968;25664;65035;259241;306575 top2a;srebf1;pparg;nr1i3;nr1d2;ckap2 TOP2A_10059;SREBF1_32750;PPARG_32510;NR1I3_32602;NR1D2_9358;CKAP2_8324 25664(0.0441) 56.946733333333334 57.574 22.095 25.691623243124702 53.207524168147714 22.26679551455361 32.14075 37.02105 12.9529 13.512522304107408 32.82897497778436 13.173822535985664 110.63271666666667 101.94749999999999 55.8619 59.275704917087815 102.88129238250397 53.68072448502939 54.9577;41.2009;60.1903;22.095;99.0234;64.2131 18.8326;31.4864;43.9036;12.9529;42.5557;43.1133 218.525;60.0774;101.057;55.8619;102.838;125.437 4 2 4 78968;25664;65035;259241 SREBF1_32750;PPARG_32510;NR1I3_32602;NR1D2_9358 55.627399999999994 50.6956 32.84599734325833 32.72465 37.02105 14.307035895320883 79.958575 80.5672 25.45926479199993 41.2009;60.1903;22.095;99.0234 31.4864;43.9036;12.9529;42.5557 60.0774;101.057;55.8619;102.838 2 360243;306575 TOP2A_10059;CKAP2_8324 59.5854 59.5854 6.544556102593976 30.97295 30.97295 17.169047621956203 171.981 171.981 65.8231560470934 54.9577;64.2131 18.8326;43.1133 218.525;125.437 0 Exp 2,3(0.5);Linear,1(0.17);Poly 2,1(0.17);Power,1(0.17) 2.067354730303368 12.668356657028198 1.5239794254302979 2.7270524501800537 0.4758679373679417 1.9885557889938354 36.389153247568586 77.50431341909808 21.32848030420693 42.95301969579306 63.20227447772133 158.06315885561202 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0097306 6 cellular response to alcohol 47 52 3 3 2 3 2 2 94 50 2401 0.68799 0.59082 1.0 3.85 286954;25664 ugt2b1;pparg UGT2B10_33303,UGT2B1_33224;PPARG_32510 25664(0.0441) 36.367225 36.367225 12.54415 33.69091576243142 41.6322660442155 32.85782236419058 25.625922499999998 25.625922499999998 7.348245 25.848539409181562 29.6653977663304 25.209368669869978 63.276425 63.276425 25.495849999999997 53.429801559253896 71.62615642841811 52.108614113290564 12.54415;60.1903 7.348245;43.9036 25.495849999999997;101.057 3 0 2 286954;25664 UGT2B10_33303,UGT2B1_33224;PPARG_32510 36.367225 36.367225 33.69091576243142 25.625922499999998 25.625922499999998 25.848539409181562 63.276425 63.276425 53.429801559253896 12.54415;60.1903 7.348245;43.9036 25.495849999999997;101.057 0 0 Exp 2,1(0.34);Exp 4,1(0.34);Poly 2,1(0.34) 1.627517209995485 4.889097332954407 1.5239794254302979 1.729828953742981 0.10303854537746666 1.635288953781128 -10.326001999999995 83.060452 -10.198325399999995 61.4501704 -10.773502 137.32635199999999 UP 1.0 0.0 0.0 GO:0044267 5 cellular protein metabolic process 443 481 12 12 9 11 9 9 87 472 1979 0.0073534 0.99708 0.015877 1.87 365813;362094;315994;24484;171142;297594;64515;114494;25649 trim59;mrps2;mapkapk3;igfbp3;ehhadh;cdca3;cdc20;ccna2;apoa2 TRIM59_10085;MRPS2_9250;MAPKAPK3_9194;IGFBP3_8881;EHHADH_8534;CDCA3_8260;CDC20_8255;CCNA2_8221;APOA2_33095 54.06113555555556 52.8265 3.54778 34.755203567107436 57.67669545810621 34.43764524410128 32.35745666666667 36.3081 1.51564 19.7144164994478 34.95861845083788 19.607089432298622 160.4812388888889 111.245 8.55785 166.520197231379 171.1800883555421 168.5619882945383 56.1278;63.3158;104.193;50.946;7.29984;46.7245;101.569;52.8265;3.54778 33.6269;45.3429;59.1667;36.3081;5.26587;21.1123;51.5499;37.3288;1.51564 121.883;111.245;434.985;85.0816;11.8779;127.486;453.17;90.0448;8.55785 3 6 3 362094;171142;25649 MRPS2_9250;EHHADH_8534;APOA2_33095 24.721140000000002 7.29984 33.47656380137603 17.374803333333332 5.26587 24.293556339701137 43.89358333333333 11.8779 58.351655317187316 63.3158;7.29984;3.54778 45.3429;5.26587;1.51564 111.245;11.8779;8.55785 6 365813;315994;24484;297594;64515;114494 TRIM59_10085;MAPKAPK3_9194;IGFBP3_8881;CDCA3_8260;CDC20_8255;CCNA2_8221 68.73113333333333 54.47715 26.63934580890954 39.84878333333334 36.81845 13.555459637860546 218.77506666666667 124.6845 175.4165960823396 56.1278;104.193;50.946;46.7245;101.569;52.8265 33.6269;59.1667;36.3081;21.1123;51.5499;37.3288 121.883;434.985;85.0816;127.486;453.17;90.0448 0 Exp 2,4(0.45);Hill,2(0.23);Linear,3(0.34) 1.9135117598965168 18.14622449874878 1.5163835287094116 3.9502921104431152 0.7940100723356734 1.7262524366378784 31.35440255837869 76.76786855273241 19.477371220360773 45.23754211297257 51.68804336438792 269.2744344133898 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0042939 8 tripeptide transport 3 3 1 1 1 1 1 1 95 2 2449 0.99588 0.10891 0.10891 33.33 83500 slc22a8 SLC22A8_9848 52.4905 52.4905 52.4905 52.4905 37.1479 37.1479 37.1479 37.1479 89.1422 89.1422 89.1422 89.1422 0.0 52.4905 0.0 52.4905 52.4905 37.1479 89.1422 1 0 1 83500 SLC22A8_9848 52.4905 52.4905 37.1479 37.1479 89.1422 89.1422 52.4905 37.1479 89.1422 0 0 Linear,1(1) 1.6520683765411377 1.6520683765411377 1.6520683765411377 1.6520683765411377 0.0 1.6520683765411377 52.4905 52.4905 37.1479 37.1479 89.1422 89.1422 UP 1.0 0.0 0.0 GO:0010243 5 response to organonitrogen compound 400 420 23 23 16 23 16 16 80 404 2047 0.58535 0.52531 1.0 3.81 286954;78968;24950;83500;24679;25664;24614;24484;63868;24471;58868;25086;114494;25612;65155;140668 ugt2b1;srebf1;srd5a1;slc22a8;prkar2b;pparg;orm1;igfbp3;hspd1;hspb1;fzd1;cyp2e1;ccna2;asns;alas1;abcc3 UGT2B10_33303,UGT2B1_33224;SREBF1_32750;SRD5A1_32503;SLC22A8_9848;PRKAR2B_33052;PPARG_32510;ORM1_9400;IGFBP3_8881;HSPD1_8849;HSPB1_8847;FZD1_8671;CYP2E1_8421;CCNA2_8221;ASNS_8091;ALAS1_8018;ABCC3_7941 25664(0.0441) 39.484780625 34.61150000000001 7.89174 23.527388815874566 39.481189841359644 20.75141359082259 27.649432187499997 26.67345 4.16797 13.80579608631184 28.162106916923147 12.94606826130899 65.710040625 54.92395 15.8079 38.35486252854701 65.72721279193446 35.438701997852945 12.54415;41.2009;29.2087;52.4905;108.746;60.1903;24.2519;50.946;34.4455;41.6322;25.231;7.89174;52.8265;28.1893;27.1843;34.7775 7.348245;31.4864;22.9308;37.1479;59.3814;43.9036;19.7133;36.3081;26.6907;30.9494;13.6792;4.16797;37.3288;23.1774;21.5215;26.6562 25.495849999999997;60.0774;39.9852;89.1422;147.467;101.057;31.358;85.0816;48.4857;63.3196;131.659;15.8079;90.0448;35.9474;36.6615;49.7705 14 3 13 286954;78968;83500;24679;25664;24614;63868;24471;58868;25086;25612;65155;140668 UGT2B10_33303,UGT2B1_33224;SREBF1_32750;SLC22A8_9848;PRKAR2B_33052;PPARG_32510;ORM1_9400;HSPD1_8849;HSPB1_8847;FZD1_8671;CYP2E1_8421;ASNS_8091;ALAS1_8018;ABCC3_7941 38.367329999999995 34.4455 25.612299230145922 26.60178576923077 26.6562 14.871122982602593 64.32685 49.7705 41.24354002967214 12.54415;41.2009;52.4905;108.746;60.1903;24.2519;34.4455;41.6322;25.231;7.89174;28.1893;27.1843;34.7775 7.348245;31.4864;37.1479;59.3814;43.9036;19.7133;26.6907;30.9494;13.6792;4.16797;23.1774;21.5215;26.6562 25.495849999999997;60.0774;89.1422;147.467;101.057;31.358;48.4857;63.3196;131.659;15.8079;35.9474;36.6615;49.7705 3 24950;24484;114494 SRD5A1_32503;IGFBP3_8881;CCNA2_8221 44.32706666666667 50.946 13.126607637288968 32.189233333333334 36.3081 8.034263996367907 71.70386666666667 85.0816 27.581038774733106 29.2087;50.946;52.8265 22.9308;36.3081;37.3288 39.9852;85.0816;90.0448 0 Exp 2,5(0.3);Exp 4,2(0.12);Linear,7(0.42);Poly 2,2(0.12);Power,1(0.06) 1.8961937745971686 33.3186559677124 1.5124053955078125 3.5849626064300537 0.5906815135078193 1.7380040884017944 27.956360105221464 51.013201144778535 20.884592105207204 34.414272269792804 46.91615798601197 84.50392326398804 UP 0.8125 0.1875 0.0 GO:0006810 4 transport 570 605 18 18 14 18 14 14 82 591 1860 0.01753 0.99137 0.036804 2.31 361604;117267;83500;503568;25664;296371;315994;63868;24471;25413;25599;25649;114628;140668 sytl2;slc26a2;slc22a8;slc13a4;pparg;pltp;mapkapk3;hspd1;hspb1;cpt2;cd74;apoa2;abcg5;abcc3 SYTL2_32351;SLC26A2_33072;SLC22A8_9848;SLC13A4_9836;PPARG_32510;PLTP_32412;MAPKAPK3_9194;HSPD1_8849;HSPB1_8847;CPT2_8374;CD74_8252;APOA2_33095;ABCG5_7947;ABCC3_7941 25664(0.0441) 54.63741285714286 53.61785 3.54778 27.775766142423883 56.75227987964267 27.952599160822096 36.856674285714284 37.7491 1.51564 15.956495274590424 38.11363481253301 16.007095393361585 105.574125 92.23975 8.55785 102.11551404867761 109.5643505110236 104.64795348628611 67.0093;54.7452;52.4905;65.6237;60.1903;87.0256;104.193;34.4455;41.6322;31.2175;94.9138;3.54778;33.1119;34.7775 44.4373;38.3503;37.1479;42.6891;43.9036;56.6266;59.1667;26.6907;30.9494;24.8356;58.8146;1.51564;24.2098;26.6562 135.846;95.3373;89.1422;135.744;101.057;104.563;434.985;48.4857;63.3196;42.0237;118.773;8.55785;50.4329;49.7705 9 5 9 83500;25664;296371;63868;24471;25413;25599;25649;140668 SLC22A8_9848;PPARG_32510;PLTP_32412;HSPD1_8849;HSPB1_8847;CPT2_8374;CD74_8252;APOA2_33095;ABCC3_7941 48.915631111111104 41.6322 28.596076412843978 34.12669333333333 30.9494 17.64743892376173 69.52139444444444 63.3196 36.01534859534236 52.4905;60.1903;87.0256;34.4455;41.6322;31.2175;94.9138;3.54778;34.7775 37.1479;43.9036;56.6266;26.6907;30.9494;24.8356;58.8146;1.51564;26.6562 89.1422;101.057;104.563;48.4857;63.3196;42.0237;118.773;8.55785;49.7705 5 361604;117267;503568;315994;114628 SYTL2_32351;SLC26A2_33072;SLC13A4_9836;MAPKAPK3_9194;ABCG5_7947 64.93661999999999 65.6237 25.79975434334599 41.77064 42.6891 12.55646621338982 170.46904 135.744 152.00882347588575 67.0093;54.7452;65.6237;104.193;33.1119 44.4373;38.3503;42.6891;59.1667;24.2098 135.846;95.3373;135.744;434.985;50.4329 0 Exp 2,5(0.36);Hill,1(0.08);Linear,6(0.43);Poly 2,2(0.15) 1.7006356906190725 24.065438628196716 1.5084086656570435 2.5319817066192627 0.28154643107304494 1.6539189219474792 40.08757677872802 69.18724893555769 28.49815090814703 45.21519766328156 52.08274755777665 159.06550244222342 UP 0.6428571428571429 0.35714285714285715 0.0 GO:0051707 4 response to other organism 231 253 11 11 9 9 8 8 88 245 2206 0.37393 0.75364 0.72841 3.16 29142;365813;84386;25211;25626;24471;25086;81633 vnn1;trim59;slpi;lyz2;krt8;hspb1;cyp2e1;acta2 VNN1_10157;TRIM59_10085;SLPI_9890;LYZ2_32611;KRT8_8978;HSPB1_8847;CYP2E1_8421;ACTA2_33040 52.157855 54.93535 7.89174 27.969661267394205 57.37915243249566 24.43993075375563 36.02979625 35.72305 4.16797 20.18481010480331 38.953022956543776 17.5959267123454 94.07553750000001 98.0565 15.8079 57.57613968191379 108.59176391905328 54.596563333132906 20.7328;56.1278;53.7429;77.8257;68.9539;41.6322;7.89174;90.3558 16.8296;33.6269;37.8192;49.2403;45.3374;30.9494;4.16797;70.2676 26.7838;121.883;92.543;185.119;143.578;63.3196;15.8079;103.57 4 4 4 29142;25626;24471;25086 VNN1_10157;KRT8_8978;HSPB1_8847;CYP2E1_8421 34.80266 31.182499999999997 26.67775843791478 24.3210925 23.889499999999998 17.77536167120729 62.372325000000004 45.0517 57.82170229647774 20.7328;68.9539;41.6322;7.89174 16.8296;45.3374;30.9494;4.16797 26.7838;143.578;63.3196;15.8079 4 365813;84386;25211;81633 TRIM59_10085;SLPI_9890;LYZ2_32611;ACTA2_33040 69.51304999999999 66.97675 17.61990282010663 47.7385 43.52975 16.404730182684087 125.77875 112.72649999999999 41.36941621032781 56.1278;53.7429;77.8257;90.3558 33.6269;37.8192;49.2403;70.2676 121.883;92.543;185.119;103.57 0 Exp 2,1(0.13);Exp 4,1(0.13);Linear,5(0.63);Poly 2,1(0.13) 1.8733110401241575 16.164913415908813 1.528815746307373 4.608505725860596 1.0515463372341403 1.65733003616333 32.77586859332814 71.53984140667187 22.042436469972216 50.01715603002778 54.17730827244738 133.97376672755263 CONFLICT 0.5 0.5 0.0 GO:0071385 8 cellular response to glucocorticoid stimulus 47 51 4 4 4 4 4 4 92 47 2404 0.9591 0.12353 0.12353 7.84 286954;24950;24614;25315 ugt2b1;srd5a1;orm1;ephx1 UGT2B10_33303,UGT2B1_33224;SRD5A1_32503;ORM1_9400;EPHX1_8567 25.004537499999998 26.7303 12.54415 9.213437753753585 24.503688496210255 8.912619346963188 19.03756125 21.32205 7.348245 8.225028249799895 18.738052898596223 7.9769989565778525 36.301787499999996 35.6716 25.495849999999997 10.006210489688808 35.344858101986816 9.79371190982437 1.5 26.7303 12.54415;29.2087;24.2519;34.0134 7.348245;22.9308;19.7133;26.1579 25.495849999999997;39.9852;31.358;48.3681 4 1 3 286954;24614;25315 UGT2B10_33303,UGT2B1_33224;ORM1_9400;EPHX1_8567 23.60315 24.2519 10.749317713813285 17.739815000000004 19.7133 9.55885780774434 35.07398333333333 31.358 11.88029267803759 12.54415;24.2519;34.0134 7.348245;19.7133;26.1579 25.495849999999997;31.358;48.3681 1 24950 SRD5A1_32503 29.2087 29.2087 22.9308 22.9308 39.9852 39.9852 29.2087 22.9308 39.9852 0 Exp 2,1(0.2);Exp 4,1(0.2);Linear,2(0.4);Poly 2,1(0.2) 2.086874813149588 10.901591181755066 1.635288953781128 3.5849626064300537 0.7996738476057775 1.9512832164764404 15.9753685013215 34.0337064986785 10.97703356519611 27.098088934803897 26.495701220104962 46.10787377989503 UP 0.75 0.25 0.0 GO:0090407 5 organophosphate biosynthetic process 89 97 5 4 4 5 3 3 93 94 2357 0.49813 0.71803 1.0 3.09 298490;364975;25649 ppcs;gcdh;apoa2 PPCS_9540;GCDH_8693;APOA2_33095 11.519660000000002 15.1091 3.54778 6.9152270606828194 10.365502142249928 7.212501522528293 6.626316666666668 7.94061 1.51564 4.596678658056632 5.791951107962596 4.658525957148798 23.49025 30.6311 8.55785 12.935929805874029 21.36830069070558 13.538375887224186 15.1091;15.9021;3.54778 7.94061;10.4227;1.51564 30.6311;31.2818;8.55785 3 0 3 298490;364975;25649 PPCS_9540;GCDH_8693;APOA2_33095 11.519660000000002 15.1091 6.9152270606828194 6.626316666666668 7.94061 4.596678658056632 23.49025 30.6311 12.935929805874029 15.1091;15.9021;3.54778 7.94061;10.4227;1.51564 30.6311;31.2818;8.55785 0 0 Hill,2(0.67);Poly 2,1(0.34) 1.7187342080066714 5.174595355987549 1.5464483499526978 1.9018945693969727 0.1777271707355982 1.7262524366378784 3.6943439182144786 19.34497608178552 1.424685091876544 11.827948241456792 8.851867390946632 38.12863260905337 UP 1.0 0.0 0.0 GO:0006310 6 DNA recombination 26 28 2 2 2 2 2 2 94 26 2425 0.91386 0.28498 0.28498 7.14 316273;63868 mcm3;hspd1 MCM3_9207;HSPD1_8849 44.225 44.225 34.4455 13.830301533227669 46.88494620483924 13.308892248219745 29.97485 29.97485 26.6907 4.644489470867595 30.868112674842553 4.469389894881245 80.11935 80.11935 48.4857 44.73673685736365 88.72345115677824 43.05013950282688 0.5 44.225 54.0045;34.4455 33.259;26.6907 111.753;48.4857 1 1 1 63868 HSPD1_8849 34.4455 34.4455 26.6907 26.6907 48.4857 48.4857 34.4455 26.6907 48.4857 1 316273 MCM3_9207 54.0045 54.0045 33.259 33.259 111.753 111.753 54.0045 33.259 111.753 0 Exp 2,2(1) 1.6570930555128898 3.314187169075012 1.6557694673538208 1.6584177017211914 0.0018725844793390219 1.657093584537506 25.057180000000006 63.39282 23.537916 36.411784 18.117396 142.121304 CONFLICT 0.5 0.5 0.0 GO:0007166 5 cell surface receptor signaling pathway 368 386 11 11 7 10 7 7 89 379 2072 0.014676 0.99431 0.028553 1.81 78968;25626;25685;24471;29455;58868;25599 srebf1;krt8;igfbp1;hspb1;gdf15;fzd1;cd74 SREBF1_32750;KRT8_8978;IGFBP1_32306;HSPB1_8847;GDF15_33113;FZD1_8671;CD74_8252 56.01918571428572 41.6322 21.3654 31.85601939777516 58.2975572175049 27.716138392397973 36.4975 31.4864 13.6792 17.949029529847383 38.59255466753756 15.989358383800685 128.73839999999998 118.773 26.3528 109.6168018871803 110.43061623514042 67.74954268098503 41.2009;68.9539;98.8371;41.6322;21.3654;25.231;94.9138 31.4864;45.3374;57.328;30.9494;17.8875;13.6792;58.8146 60.0774;143.578;357.409;63.3196;26.3528;131.659;118.773 7 0 7 78968;25626;25685;24471;29455;58868;25599 SREBF1_32750;KRT8_8978;IGFBP1_32306;HSPB1_8847;GDF15_33113;FZD1_8671;CD74_8252 56.01918571428572 41.6322 31.85601939777516 36.4975 31.4864 17.949029529847383 128.73839999999998 118.773 109.6168018871803 41.2009;68.9539;98.8371;41.6322;21.3654;25.231;94.9138 31.4864;45.3374;57.328;30.9494;17.8875;13.6792;58.8146 60.0774;143.578;357.409;63.3196;26.3528;131.659;118.773 0 0 Exp 2,2(0.29);Linear,3(0.43);Poly 2,2(0.29) 2.0331616332248195 15.567980289459229 1.5124053955078125 5.015069484710693 1.2445457440147942 1.8468482494354248 32.419916289936154 79.61845513863527 23.200672844939387 49.794327155060614 47.533136753839855 209.9436632461601 UP 1.0 0.0 0.0 GO:0006139 4 nucleobase-containing compound metabolic process 359 401 21 20 19 21 18 18 78 383 2068 0.83404 0.2427 0.3928 4.49 360243;360268;64305;78968;298490;313245;291234;316273;293502;63868;364975;362485;24763;681337;314304;192272;50559;170465 top2a;sult1e1;sult1b1;srebf1;ppcs;polr1e;mki67;mcm3;kif22;hspd1;gcdh;ccne2;acsm3;acot4;acot3;acot2;acot1;acaa2 TOP2A_10059;SULT1E1_32446;SULT1B1_32942;SREBF1_32750;PPCS_9540;POLR1E_9523;MKI67_9232;MCM3_9207;KIF22_8963;HSPD1_8849;GCDH_8693;CCNE2_8227;ACSM3_7976;ACOT4_7971;ACOT3_7970;ACOT2_7969;ACOT1_7968;ACAA2_7955 43.43778888888889 45.491550000000004 12.3157 23.701116986681026 43.389713735025126 23.32765639842459 28.614063333333334 29.088549999999998 6.70485 15.377252059540275 28.28656704431276 15.193413273949671 84.00480555555556 65.595 16.9658 61.92666904085709 81.71878550925328 56.76879267838493 54.9577;59.2729;15.4629;41.2009;15.1091;73.982;49.7822;54.0045;73.9175;34.4455;15.9021;77.8893;52.2057;12.3157;30.8838;13.6362;28.5134;78.3988 18.8326;45.3114;7.69418;31.4864;7.94061;47.589;35.6665;33.259;47.5608;26.6907;10.4227;49.2672;42.2655;6.70485;24.6874;11.3249;24.741;43.6084 218.525;91.5578;35.0879;60.0774;30.6311;165.722;82.1147;111.753;165.416;48.4857;31.2818;185.461;71.1126;24.3993;41.2585;16.9658;33.4642;98.7727 12 6 12 360268;64305;78968;298490;313245;63868;364975;24763;681337;314304;192272;50559 SULT1E1_32446;SULT1B1_32942;SREBF1_32750;PPCS_9540;POLR1E_9523;HSPD1_8849;GCDH_8693;ACSM3_7976;ACOT4_7971;ACOT3_7970;ACOT2_7969;ACOT1_7968 32.74418333333333 29.6986 20.348296105831714 23.90488666666667 24.714199999999998 15.304044313166086 54.170341666666666 38.173199999999994 41.01431761351946 59.2729;15.4629;41.2009;15.1091;73.982;34.4455;15.9021;52.2057;12.3157;30.8838;13.6362;28.5134 45.3114;7.69418;31.4864;7.94061;47.589;26.6907;10.4227;42.2655;6.70485;24.6874;11.3249;24.741 91.5578;35.0879;60.0774;30.6311;165.722;48.4857;31.2818;71.1126;24.3993;41.2585;16.9658;33.4642 6 360243;291234;316273;293502;362485;170465 TOP2A_10059;MKI67_9232;MCM3_9207;KIF22_8963;CCNE2_8227;ACAA2_7955 64.825 64.4376 13.253906583041882 38.03241666666667 39.63745 11.3588561396677 143.67373333333333 138.5845 54.12238821920807 54.9577;49.7822;54.0045;73.9175;77.8893;78.3988 18.8326;35.6665;33.259;47.5608;49.2672;43.6084 218.525;82.1147;111.753;165.416;185.461;98.7727 0 Exp 2,8(0.45);Exp 4,1(0.06);Hill,2(0.12);Linear,5(0.28);Poly 2,2(0.12) 2.45291963424666 87.39189279079437 1.5184675455093384 50.888092041015625 11.51156047157356 1.9072250127792358 32.48843146747671 54.38714631030107 21.51013531788706 35.717991348779606 55.3961440470333 112.61346706407782 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0009889 5 regulation of biosynthetic process 634 681 23 23 16 23 16 16 80 665 1786 0.012781 0.99367 0.024943 2.35 360243;78968;25664;363465;54133;65035;259241;63868;24471;58868;25427;65210;306575;25599;114494;25649 top2a;srebf1;pparg;pir;pdlim1;nr1i3;nr1d2;hspd1;hspb1;fzd1;cyp51;cyp2j4;ckap2;cd74;ccna2;apoa2 TOP2A_10059;SREBF1_32750;PPARG_32510;PIR_9487;PDLIM1_9452;NR1I3_32602;NR1D2_9358;HSPD1_8849;HSPB1_8847;FZD1_8671;CYP51_8429;CYP2J4_32580;CKAP2_8324;CD74_8252;CCNA2_8221;APOA2_33095 25664(0.0441) 50.3137675 52.4936 3.54778 26.785118277423514 48.67835767433045 26.217062906065124 31.647808749999996 34.4076 1.51564 16.511003406121578 31.664708940401976 16.981648274912953 95.730071875 95.5509 8.55785 52.94940649622043 89.00809894020249 48.36174458667566 54.9577;41.2009;60.1903;52.1607;67.1147;22.095;99.0234;34.4455;41.6322;25.231;75.1522;16.3155;64.2131;94.9138;52.8265;3.54778 18.8326;31.4864;43.9036;40.9644;47.2419;12.9529;42.5557;26.6907;30.9494;13.6792;48.098;8.2378;43.1133;58.8146;37.3288;1.51564 218.525;60.0774;101.057;74.9097;123.914;55.8619;102.838;48.4857;63.3196;131.659;171.379;36.8422;125.437;118.773;90.0448;8.55785 12 4 12 78968;25664;363465;54133;65035;259241;63868;24471;58868;65210;25599;25649 SREBF1_32750;PPARG_32510;PIR_9487;PDLIM1_9452;NR1I3_32602;NR1D2_9358;HSPD1_8849;HSPB1_8847;FZD1_8671;CYP2J4_32580;CD74_8252;APOA2_33095 46.48923166666666 41.41655 29.76895029490286 29.91602 31.2179 17.7216864480803 77.19127916666666 69.11465 38.39291377435695 41.2009;60.1903;52.1607;67.1147;22.095;99.0234;34.4455;41.6322;25.231;16.3155;94.9138;3.54778 31.4864;43.9036;40.9644;47.2419;12.9529;42.5557;26.6907;30.9494;13.6792;8.2378;58.8146;1.51564 60.0774;101.057;74.9097;123.914;55.8619;102.838;48.4857;63.3196;131.659;36.8422;118.773;8.55785 4 360243;25427;306575;114494 TOP2A_10059;CYP51_8429;CKAP2_8324;CCNA2_8221 61.787375 59.5854 10.188955301820696 36.843175 40.221050000000005 12.788043853113981 151.34645 148.408 55.80756379927366 54.9577;75.1522;64.2131;52.8265 18.8326;48.098;43.1133;37.3288 218.525;171.379;125.437;90.0448 0 Exp 2,6(0.38);Exp 4,1(0.07);Hill,1(0.07);Linear,4(0.25);Poly 2,3(0.19);Power,1(0.07) 1.874067263005694 30.46077048778534 1.5124053955078125 2.7270524501800537 0.3676006868503685 1.8264771699905396 37.18905954406249 63.43847545593752 23.55741708100043 39.738200418999575 69.784862691852 121.67528105814802 UP 0.75 0.25 0.0 GO:0045069 7 regulation of viral genome replication 22 24 2 2 2 2 2 2 94 22 2429 0.94078 0.22823 0.22823 8.33 360243;84386 top2a;slpi TOP2A_10059;SLPI_9890 54.350300000000004 54.350300000000004 53.7429 0.8589933177851554 54.1529838011696 0.8124051669931984 28.3259 28.3259 18.8326 13.425553611676515 31.40983459064328 12.69740858054382 155.534 155.534 92.543 89.08272650744367 135.07113421052634 84.25125761295178 0.5 54.350300000000004 54.9577;53.7429 18.8326;37.8192 218.525;92.543 0 2 0 2 360243;84386 TOP2A_10059;SLPI_9890 54.350300000000004 54.350300000000004 0.8589933177851554 28.3259 28.3259 13.425553611676515 155.534 155.534 89.08272650744367 54.9577;53.7429 18.8326;37.8192 218.525;92.543 0 Exp 2,1(0.5);Linear,1(0.5) 1.7594684793838127 3.5201412439346313 1.714035153388977 1.8061060905456543 0.06510398401368694 1.7600706219673157 53.159796 55.54080400000001 9.719031999999999 46.932768 32.07163999999999 278.99636 DOWN 0.0 1.0 0.0 GO:0006974 5 cellular response to DNA damage stimulus 142 151 4 4 3 4 3 3 93 148 2303 0.16724 0.93243 0.3732 1.99 360243;316273;293502 top2a;mcm3;kif22 TOP2A_10059;MCM3_9207;KIF22_8963 60.959900000000005 54.9577 54.0045 11.231727199322433 60.41674024035666 11.126036264454383 33.21746666666667 33.259 18.8326 14.364145034541155 34.48276662143826 12.772061893821528 165.2313333333333 165.416 111.753 53.38623954104037 152.35215720100794 51.95226381058693 54.9577;54.0045;73.9175 18.8326;33.259;47.5608 218.525;111.753;165.416 0 3 0 3 360243;316273;293502 TOP2A_10059;MCM3_9207;KIF22_8963 60.959900000000005 54.9577 11.231727199322433 33.21746666666667 33.259 14.364145034541155 165.2313333333333 165.416 53.38623954104037 54.9577;54.0045;73.9175 18.8326;33.259;47.5608 218.525;111.753;165.416 0 Exp 2,2(0.67);Linear,1(0.34) 1.822433768289382 5.485299348831177 1.6584177017211914 2.020775556564331 0.18220778194176715 1.8061060905456543 48.25000418489319 73.6697958151068 16.962906382019185 49.47202695131415 104.81911618405209 225.6435504826146 DOWN 0.0 1.0 0.0 GO:0090304 5 nucleic acid metabolic process 251 278 10 9 9 10 8 8 88 270 2181 0.26225 0.84021 0.50526 2.88 360243;78968;313245;291234;316273;293502;63868;362485 top2a;srebf1;polr1e;mki67;mcm3;kif22;hspd1;ccne2 TOP2A_10059;SREBF1_32750;POLR1E_9523;MKI67_9232;MCM3_9207;KIF22_8963;HSPD1_8849;CCNE2_8227 57.52245 54.4811 34.4455 16.179029770309832 53.766083017033885 14.830721030540662 36.294025000000005 34.46275 18.8326 11.036715254969906 34.37625004397334 9.640945321530902 129.69435000000001 138.5845 48.4857 62.79434821128411 116.27180932003333 60.48294154195468 54.9577;41.2009;73.982;49.7822;54.0045;73.9175;34.4455;77.8893 18.8326;31.4864;47.589;35.6665;33.259;47.5608;26.6907;49.2672 218.525;60.0774;165.722;82.1147;111.753;165.416;48.4857;185.461 3 5 3 78968;313245;63868 SREBF1_32750;POLR1E_9523;HSPD1_8849 49.876133333333335 41.2009 21.14777678866819 35.25536666666667 31.4864 10.947080342417033 91.42836666666666 60.0774 64.600695372599 41.2009;73.982;34.4455 31.4864;47.589;26.6907 60.0774;165.722;48.4857 5 360243;291234;316273;293502;362485 TOP2A_10059;MKI67_9232;MCM3_9207;KIF22_8963;CCNE2_8227 62.11024 54.9577 12.818273507302024 36.91722 35.6665 12.326882775543872 152.65393999999998 165.416 55.28752386269444 54.9577;49.7822;54.0045;73.9175;77.8893 18.8326;35.6665;33.259;47.5608;49.2672 218.525;82.1147;111.753;165.416;185.461 0 Exp 2,4(0.5);Linear,4(0.5) 1.7907695397021413 14.447500467300415 1.5184675455093384 2.285626173019409 0.25670954360210374 1.7322618961334229 46.31095436966701 68.73394563033301 28.64597152516204 43.942078474837956 86.18008674841944 173.20861325158057 DOWN 0.375 0.625 0.0 GO:1901215 7 negative regulation of neuron death 102 106 4 4 3 4 3 3 93 103 2348 0.42658 0.77296 0.79657 2.83 309607;63868;58868 rt1-ce5;hspd1;fzd1 RT1-CE5_32445;HSPD1_8849;FZD1_8671 38.1657 34.4455 25.231 15.141533048869254 39.51341096118299 15.253087306201424 22.32003333333333 26.5902 13.6792 7.483349890479094 22.952959118915587 7.159606193624364 109.3229 131.659 48.4857 53.30291252952319 109.6189426802218 54.128895227768254 54.8206;34.4455;25.231 26.5902;26.6907;13.6792 147.824;48.4857;131.659 2 1 2 63868;58868 HSPD1_8849;FZD1_8671 29.838250000000002 29.838250000000002 6.515635435243442 20.18495 20.18495 9.200519883408761 90.07235 90.07235 58.812404443663056 34.4455;25.231 26.6907;13.6792 48.4857;131.659 1 309607 RT1-CE5_32445 54.8206 54.8206 26.5902 26.5902 147.824 147.824 54.8206 26.5902 147.824 0 Exp 2,2(0.67);Poly 2,1(0.34) 1.6663032329318772 5.015715599060059 1.5124053955078125 1.8475407361984253 0.16814932512023853 1.6557694673538208 21.03144236385177 55.299957636148235 13.85182574886515 30.78824091780152 49.00497624087788 169.64082375912213 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0042742 5 defense response to bacterium 57 66 3 3 2 3 2 2 94 64 2387 0.54304 0.72003 1.0 3.03 84386;25211 slpi;lyz2 SLPI_9890;LYZ2_32611 65.7843 65.7843 53.7429 17.029111189959345 65.67163820449989 17.028365821759515 43.52975 43.52975 37.8192 8.075937258609672 43.476320928937405 8.075583772937435 138.83100000000002 138.83100000000002 92.543 65.46111737512572 138.397920026732 65.45825212663038 53.7429;77.8257 37.8192;49.2403 92.543;185.119 0 2 0 2 84386;25211 SLPI_9890;LYZ2_32611 65.7843 65.7843 17.029111189959345 43.52975 43.52975 8.075937258609672 138.83100000000002 138.83100000000002 65.46111737512572 53.7429;77.8257 37.8192;49.2403 92.543;185.119 0 Linear,2(1) 1.7287748291456817 3.457676410675049 1.714035153388977 1.7436412572860718 0.020934676830149154 1.7288382053375244 42.18315600000001 89.38544399999999 32.337072000000006 54.722427999999994 48.10652000000002 229.55548000000002 DOWN 0.0 1.0 0.0 GO:0001676 7 long-chain fatty acid metabolic process 44 52 14 14 14 14 14 14 82 38 2413 1.0 2.4533E-9 2.4533E-9 26.92 65030;25315;50549;65210;25086;24303;499353;171521;29277;24894;681337;314304;192272;50559 ephx2;ephx1;cyp4a1;cyp2j4;cyp2e1;cyp2d3;cyp2c24;cyp2c13;cyp2c11;cyp2a1;acot4;acot3;acot2;acot1 EPHX2_33282;EPHX1_8567;CYP4A1_33111;CYP2J4_32580;CYP2E1_8421;CYP2D3_8420;CYP2C24_32875;CYP2C13_8419;CYP2C11_32593;CYP2A1_32717;ACOT4_7971;ACOT3_7970;ACOT2_7969;ACOT1_7968 29.528675714285708 19.76175 6.44145 27.17403990841647 33.291051601932395 31.645198407353742 20.194460714285714 15.09395 2.66377 16.6325869264301 21.769634324024768 18.792396223282303 40.698335714285726 31.72475 15.8079 28.214122613646108 45.45042873406742 32.27236025250998 1.5 8.631805 4.5 13.22105 6.44145;34.0134;23.208;16.3155;7.89174;12.8059;58.9435;104.635;54.426;9.37187;12.3157;30.8838;13.6362;28.5134 2.66377;26.1579;18.863;8.2378;4.16797;8.8664;48.1505;49.2461;43.9518;4.95906;6.70485;24.6874;11.3249;24.741 17.3473;48.3681;29.9853;36.8422;15.8079;22.6004;80.4167;108.327;74.8861;19.1079;24.3993;41.2585;16.9658;33.4642 14 0 14 65030;25315;50549;65210;25086;24303;499353;171521;29277;24894;681337;314304;192272;50559 EPHX2_33282;EPHX1_8567;CYP4A1_33111;CYP2J4_32580;CYP2E1_8421;CYP2D3_8420;CYP2C24_32875;CYP2C13_8419;CYP2C11_32593;CYP2A1_32717;ACOT4_7971;ACOT3_7970;ACOT2_7969;ACOT1_7968 29.528675714285708 19.76175 27.17403990841647 20.194460714285714 15.09395 16.6325869264301 40.698335714285726 31.72475 28.214122613646108 6.44145;34.0134;23.208;16.3155;7.89174;12.8059;58.9435;104.635;54.426;9.37187;12.3157;30.8838;13.6362;28.5134 2.66377;26.1579;18.863;8.2378;4.16797;8.8664;48.1505;49.2461;43.9518;4.95906;6.70485;24.6874;11.3249;24.741 17.3473;48.3681;29.9853;36.8422;15.8079;22.6004;80.4167;108.327;74.8861;19.1079;24.3993;41.2585;16.9658;33.4642 0 0 Exp 2,5(0.36);Exp 4,4(0.29);Hill,1(0.08);Linear,2(0.15);Poly 2,1(0.08);Power,1(0.08) 2.8712580926604034 82.09355080127716 1.5310101509094238 50.888092041015625 12.980450176574253 2.3720505237579346 15.294043113031423 43.76330831554001 11.481778871464554 28.907142557106866 25.918874473868463 55.477796954702974 UP 1.0 0.0 0.0 GO:0065008 3 regulation of biological quality 821 880 36 35 27 36 26 26 70 854 1597 0.070383 0.9555 0.12625 2.95 361604;360268;64305;78968;24950;64159;299270;25664;65035;259241;24484;63868;65030;117543;499353;25413;64515;25599;362485;25649;155423;502970;81633;50681;170465;114628 sytl2;sult1e1;sult1b1;srebf1;srd5a1;sptan1;serpina6;pparg;nr1i3;nr1d2;igfbp3;hspd1;ephx2;decr1;cyp2c24;cpt2;cdc20;cd74;ccne2;apoa2;anxa7;angptl3;acta2;acox1;acaa2;abcg5 SYTL2_32351;SULT1E1_32446;SULT1B1_32942;SREBF1_32750;SRD5A1_32503;SPTAN1_9932;SERPINA6_32325;PPARG_32510;NR1I3_32602;NR1D2_9358;IGFBP3_8881;HSPD1_8849;EPHX2_33282;DECR1_8458;CYP2C24_32875;CPT2_8374;CDC20_8255;CD74_8252;CCNE2_8227;APOA2_33095;ANXA7_8051;ANGPTL3_8045;ACTA2_33040;ACOX1_7973;ACAA2_7955;ABCG5_7947 25664(0.0441) 51.517005000000005 54.50945 3.54778 28.51548699936948 50.46251295146039 27.847536523469532 33.86860346153846 36.638000000000005 1.51564 17.13527449623914 33.45155268591184 17.38090603905712 91.25157884615383 82.74915 8.55785 84.55111609797494 86.46106049949597 76.34740715565768 67.0093;59.2729;15.4629;41.2009;29.2087;47.5519;68.3847;60.1903;22.095;99.0234;50.946;34.4455;6.44145;21.6199;58.9435;31.2175;101.569;94.9138;77.8893;3.54778;64.7676;58.0729;90.3558;23.8014;78.3988;33.1119 44.4373;45.3114;7.69418;31.4864;22.9308;34.4152;36.9679;43.9036;12.9529;42.5557;36.3081;26.6907;2.66377;17.4928;48.1505;24.8356;51.5499;58.8146;49.2672;1.51564;43.3787;40.0757;70.2676;19.0993;43.6084;24.2098 135.846;91.5578;35.0879;60.0774;39.9852;76.6397;89.5095;101.057;55.8619;102.838;85.0816;48.4857;17.3473;28.0829;80.4167;42.0237;453.17;118.773;185.461;8.55785;127.439;105.112;103.57;31.3543;98.7727;50.4329 18 8 18 360268;64305;78968;64159;299270;25664;65035;259241;63868;65030;117543;499353;25413;25599;25649;155423;502970;50681 SULT1E1_32446;SULT1B1_32942;SREBF1_32750;SPTAN1_9932;SERPINA6_32325;PPARG_32510;NR1I3_32602;NR1D2_9358;HSPD1_8849;EPHX2_33282;DECR1_8458;CYP2C24_32875;CPT2_8374;CD74_8252;APOA2_33095;ANXA7_8051;ANGPTL3_8045;ACOX1_7973 45.05296277777777 44.376400000000004 27.725213792562396 29.88914388888889 32.9508 16.72497059120289 67.79009166666668 68.35855000000001 36.319278170213764 59.2729;15.4629;41.2009;47.5519;68.3847;60.1903;22.095;99.0234;34.4455;6.44145;21.6199;58.9435;31.2175;94.9138;3.54778;64.7676;58.0729;23.8014 45.3114;7.69418;31.4864;34.4152;36.9679;43.9036;12.9529;42.5557;26.6907;2.66377;17.4928;48.1505;24.8356;58.8146;1.51564;43.3787;40.0757;19.0993 91.5578;35.0879;60.0774;76.6397;89.5095;101.057;55.8619;102.838;48.4857;17.3473;28.0829;80.4167;42.0237;118.773;8.55785;127.439;105.112;31.3543 8 361604;24950;24484;64515;362485;81633;170465;114628 SYTL2_32351;SRD5A1_32503;IGFBP3_8881;CDC20_8255;CCNE2_8227;ACTA2_33040;ACAA2_7955;ABCG5_7947 66.0611 72.4493 26.230524924435453 42.822387500000005 44.022850000000005 15.3934593631226 144.039925 101.17134999999999 133.1470350671741 67.0093;29.2087;50.946;101.569;77.8893;90.3558;78.3988;33.1119 44.4373;22.9308;36.3081;51.5499;49.2672;70.2676;43.6084;24.2098 135.846;39.9852;85.0816;453.17;185.461;103.57;98.7727;50.4329 0 Exp 2,8(0.31);Exp 4,2(0.08);Hill,1(0.04);Linear,9(0.35);Poly 2,5(0.2);Power,1(0.04) 1.8410906715547468 48.89077043533325 1.5062377452850342 2.9455835819244385 0.42210719214825926 1.7274702787399292 40.55600468027702 62.47800531972296 27.282015996419215 40.45519092665773 58.751176149074574 123.75198154323314 UP 0.6923076923076923 0.3076923076923077 0.0 GO:0043122 7 regulation of I-kappaB kinase/NF-kappaB signaling 56 62 3 3 3 3 3 3 93 59 2392 0.7963 0.4164 0.50607 4.84 365813;24471;25599 trim59;hspb1;cd74 TRIM59_10085;HSPB1_8847;CD74_8252 64.2246 56.1278 41.6322 27.54815515275028 67.09623876280762 27.882807427543625 41.1303 33.6269 30.9494 15.373454440365688 42.60910158000574 15.787090382522635 101.3252 118.773 63.3196 32.950527287435044 104.51788887292923 31.197391721265756 56.1278;41.6322;94.9138 33.6269;30.9494;58.8146 121.883;63.3196;118.773 2 1 2 24471;25599 HSPB1_8847;CD74_8252 68.273 68.273 37.67578067246917 44.882 44.882 19.70367187911938 91.0463 91.0463 39.21147517985007 41.6322;94.9138 30.9494;58.8146 63.3196;118.773 1 365813 TRIM59_10085 56.1278 56.1278 33.6269 33.6269 121.883 121.883 56.1278 33.6269 121.883 0 Exp 2,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 1.6727604771899731 5.033398270606995 1.528815746307373 1.8468482494354248 0.1599628891489512 1.6577342748641968 33.05092780548885 95.39827219451115 23.733598603341612 58.527001396658385 64.03816823329218 138.6122317667078 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0010660 8 regulation of muscle cell apoptotic process 35 39 3 3 3 3 3 3 93 36 2415 0.9431 0.17995 0.17995 7.69 25664;24484;50559 pparg;igfbp3;acot1 PPARG_32510;IGFBP3_8881;ACOT1_7968 25664(0.0441) 46.5499 50.946 28.5134 16.289590842314002 52.31395150505875 13.663791202701937 34.98423333333333 36.3081 24.741 9.649651646734892 38.53034375667693 8.432480460302257 73.20093333333334 85.0816 33.4642 35.32788322689789 85.38953614026266 29.061349933530504 0.5 39.7297 60.1903;50.946;28.5134 43.9036;36.3081;24.741 101.057;85.0816;33.4642 2 1 2 25664;50559 PPARG_32510;ACOT1_7968 44.35185 44.35185 22.398950796968144 34.3223 34.3223 13.55000440516533 67.2606 67.2606 47.7953272393861 60.1903;28.5134 43.9036;24.741 101.057;33.4642 1 24484 IGFBP3_8881 50.946 50.946 36.3081 36.3081 85.0816 85.0816 50.946 36.3081 85.0816 0 Exp 2,2(0.67);Linear,1(0.34) 5.127220817241749 54.15007555484772 1.5239794254302979 50.888092041015625 28.438801447524195 1.7380040884017944 28.116492670714255 64.98330732928575 24.064624540709467 45.903842125957205 33.22367006707296 113.17819659959369 UP 0.6666666666666666 0.3333333333333333 0.0 GO:1901135 4 carbohydrate derivative metabolic process 159 175 12 12 11 12 11 11 85 164 2287 0.9709 0.061563 0.094618 6.29 360268;64305;298490;291234;364975;24763;681337;314304;192272;50559;170465 sult1e1;sult1b1;ppcs;mki67;gcdh;acsm3;acot4;acot3;acot2;acot1;acaa2 SULT1E1_32446;SULT1B1_32942;PPCS_9540;MKI67_9232;GCDH_8693;ACSM3_7976;ACOT4_7971;ACOT3_7970;ACOT2_7969;ACOT1_7968;ACAA2_7955 33.77116363636364 28.5134 12.3157 22.677418505741453 35.53879502170928 25.455995875915534 23.66976727272727 24.6874 6.70485 15.735723893266618 23.94467726797046 17.13900589545205 50.604218181818176 35.0879 16.9658 29.365462203303327 54.04585764649126 32.69471243756312 7.5 50.99395 59.2729;15.4629;15.1091;49.7822;15.9021;52.2057;12.3157;30.8838;13.6362;28.5134;78.3988 45.3114;7.69418;7.94061;35.6665;10.4227;42.2655;6.70485;24.6874;11.3249;24.741;43.6084 91.5578;35.0879;30.6311;82.1147;31.2818;71.1126;24.3993;41.2585;16.9658;33.4642;98.7727 9 2 9 360268;64305;298490;364975;24763;681337;314304;192272;50559 SULT1E1_32446;SULT1B1_32942;PPCS_9540;GCDH_8693;ACSM3_7976;ACOT4_7971;ACOT3_7970;ACOT2_7969;ACOT1_7968 27.033533333333335 15.9021 17.628502946577733 20.12139333333333 11.3249 15.088657887485391 41.751 33.4642 23.991601002955186 59.2729;15.4629;15.1091;15.9021;52.2057;12.3157;30.8838;13.6362;28.5134 45.3114;7.69418;7.94061;10.4227;42.2655;6.70485;24.6874;11.3249;24.741 91.5578;35.0879;30.6311;31.2818;71.1126;24.3993;41.2585;16.9658;33.4642 2 291234;170465 MKI67_9232;ACAA2_7955 64.09049999999999 64.09049999999999 20.234991914503013 39.63745 39.63745 5.615771345505431 90.4437 90.4437 11.778984761005358 49.7822;78.3988 35.6665;43.6084 82.1147;98.7727 0 Exp 2,4(0.37);Exp 4,1(0.1);Hill,2(0.19);Linear,2(0.19);Poly 2,2(0.19) 3.0638787778285783 75.23001849651337 1.5464483499526978 50.888092041015625 14.632961724152516 2.3701579570770264 20.369665703734853 47.172661568992424 14.370548705559287 32.96898583989526 33.25033899540985 67.95809736822653 UP 0.8181818181818182 0.18181818181818182 0.0 GO:0006693 7 prostaglandin metabolic process 9 14 2 2 2 2 2 2 94 12 2439 0.98604 0.095353 0.095353 14.29 25599;50681 cd74;acox1 CD74_8252;ACOX1_7973 59.3576 59.3576 23.8014 50.284060266450254 81.54664593532789 39.29095567480916 38.95695 38.95695 19.0993 28.082957946858087 51.349227802961614 21.94345981729977 75.06365 75.06365 31.3543 61.81435557251244 102.34071489876096 48.300497056061 0.0 23.8014 0.5 59.3576 94.9138;23.8014 58.8146;19.0993 118.773;31.3543 2 0 2 25599;50681 CD74_8252;ACOX1_7973 59.3576 59.3576 50.284060266450254 38.95695 38.95695 28.082957946858087 75.06365 75.06365 61.81435557251244 94.9138;23.8014 58.8146;19.0993 118.773;31.3543 0 0 Linear,1(0.5);Poly 2,1(0.5) 1.6150083803640316 3.2311179637908936 1.5733836889266968 1.6577342748641968 0.05964487131346489 1.6155589818954468 -10.332552 129.047752 0.03595599999999877 77.877944 -10.606675999999993 160.73397599999998 UP 1.0 0.0 0.0 GO:2001243 8 negative regulation of intrinsic apoptotic signaling pathway 39 41 3 3 3 3 3 3 93 38 2413 0.93378 0.1993 0.1993 7.32 29142;24471;25599 vnn1;hspb1;cd74 VNN1_10157;HSPB1_8847;CD74_8252 52.42626666666666 41.6322 20.7328 38.25034766709099 65.24417364475559 37.20712668421243 35.5312 30.9494 16.8296 21.364215985614834 42.84048730561923 20.309132438792624 69.62546666666667 63.3196 26.7838 46.31766612183015 85.77356694132953 42.83106956114798 1.5 68.273 20.7328;41.6322;94.9138 16.8296;30.9494;58.8146 26.7838;63.3196;118.773 3 0 3 29142;24471;25599 VNN1_10157;HSPB1_8847;CD74_8252 52.42626666666666 41.6322 38.25034766709099 35.5312 30.9494 21.364215985614834 69.62546666666667 63.3196 46.31766612183015 20.7328;41.6322;94.9138 16.8296;30.9494;58.8146 26.7838;63.3196;118.773 0 0 Linear,2(0.67);Poly 2,1(0.34) 2.416399590603303 8.113088250160217 1.6577342748641968 4.608505725860596 1.651744949464483 1.8468482494354248 9.141923563170813 95.7106097701625 11.355313733372746 59.70708626662725 17.212093339465916 122.03883999386741 UP 1.0 0.0 0.0 GO:0006805 4 xenobiotic metabolic process 43 62 9 9 9 9 9 9 87 53 2398 0.99992 4.077E-4 4.077E-4 14.52 286954;64305;65210;25086;24303;499353;171521;29277;24894 ugt2b1;sult1b1;cyp2j4;cyp2e1;cyp2d3;cyp2c24;cyp2c13;cyp2c11;cyp2a1 UGT2B10_33303,UGT2B1_33224;SULT1B1_32942;CYP2J4_32580;CYP2E1_8421;CYP2D3_8420;CYP2C24_32875;CYP2C13_8419;CYP2C11_32593;CYP2A1_32717 32.488506666666666 15.4629 7.89174 33.283322405141206 35.25656103551733 34.237001020316946 20.291339444444443 8.2378 4.16797 20.221892186779662 21.93707294982427 20.47465408282595 46.50799444444445 35.0879 15.8079 32.99033387856249 49.78277048889905 33.215103106400754 2.5 12.675025 5.5 35.37075 12.54415;15.4629;16.3155;7.89174;12.8059;58.9435;104.635;54.426;9.37187 7.348245;7.69418;8.2378;4.16797;8.8664;48.1505;49.2461;43.9518;4.95906 25.495849999999997;35.0879;36.8422;15.8079;22.6004;80.4167;108.327;74.8861;19.1079 10 0 9 286954;64305;65210;25086;24303;499353;171521;29277;24894 UGT2B10_33303,UGT2B1_33224;SULT1B1_32942;CYP2J4_32580;CYP2E1_8421;CYP2D3_8420;CYP2C24_32875;CYP2C13_8419;CYP2C11_32593;CYP2A1_32717 32.488506666666666 15.4629 33.283322405141206 20.291339444444443 8.2378 20.221892186779662 46.50799444444445 35.0879 32.99033387856249 12.54415;15.4629;16.3155;7.89174;12.8059;58.9435;104.635;54.426;9.37187 7.348245;7.69418;8.2378;4.16797;8.8664;48.1505;49.2461;43.9518;4.95906 25.495849999999997;35.0879;36.8422;15.8079;22.6004;80.4167;108.327;74.8861;19.1079 0 0 Exp 2,2(0.2);Exp 4,5(0.5);Poly 2,2(0.2);Power,1(0.1) 1.9497172943453116 20.075350403785706 1.5310101509094238 2.9415390491485596 0.5356909214360905 1.7390993237495422 10.74340269530774 54.233610638025596 7.079703215748399 33.50297567314048 24.95430964378362 68.06167924510527 UP 1.0 0.0 0.0 GO:0061077 4 chaperone-mediated protein folding 17 21 2 2 2 2 2 2 94 19 2432 0.95782 0.18628 0.18628 9.52 24471;25599 hspb1;cd74 HSPB1_8847;CD74_8252 68.273 68.273 41.6322 37.67578067246917 72.69707614639086 37.15265198854414 44.882 44.882 30.9494 19.70367187911938 47.19570241573845 19.430086149649828 91.0463 91.0463 63.3196 39.21147517985007 95.65070497613192 38.66702335856155 0.5 68.273 41.6322;94.9138 30.9494;58.8146 63.3196;118.773 2 0 2 24471;25599 HSPB1_8847;CD74_8252 68.273 68.273 37.67578067246917 44.882 44.882 19.70367187911938 91.0463 91.0463 39.21147517985007 41.6322;94.9138 30.9494;58.8146 63.3196;118.773 0 0 Linear,1(0.5);Poly 2,1(0.5) 1.749738164286887 3.5045825242996216 1.6577342748641968 1.8468482494354248 0.13372377383645564 1.7522912621498108 16.057032000000007 120.48896799999999 17.574104000000002 72.18989599999999 36.701968000000015 145.39063199999998 UP 1.0 0.0 0.0 GO:0051246 6 regulation of protein metabolic process 635 675 25 25 18 24 18 18 78 657 1794 0.047371 0.97287 0.098039 2.67 78968;84386;299270;24679;25664;24484;63868;24471;29455;299626;58868;25427;64515;25599;362485;114494;25649;81633 srebf1;slpi;serpina6;prkar2b;pparg;igfbp3;hspd1;hspb1;gdf15;gadd45b;fzd1;cyp51;cdc20;cd74;ccne2;ccna2;apoa2;acta2 SREBF1_32750;SLPI_9890;SERPINA6_32325;PRKAR2B_33052;PPARG_32510;IGFBP3_8881;HSPD1_8849;HSPB1_8847;GDF15_33113;GADD45B_8679;FZD1_8671;CYP51_8429;CDC20_8255;CD74_8252;CCNE2_8227;CCNA2_8221;APOA2_33095;ACTA2_33040 25664(0.0441) 58.59506000000002 53.2847 3.54778 28.991860436025387 58.08729184411354 26.837408620216433 38.28371888888889 37.2603 1.51564 17.028967436136874 38.269371502756364 16.06938720211298 114.77045833333334 91.29390000000001 8.55785 96.03963354964183 107.05266886734154 88.44257970210697 41.2009;53.7429;68.3847;108.746;60.1903;50.946;34.4455;41.6322;21.3654;52.5718;25.231;75.1522;101.569;94.9138;77.8893;52.8265;3.54778;90.3558 31.4864;37.8192;36.9679;59.3814;43.9036;36.3081;26.6907;30.9494;17.8875;37.1918;13.6792;48.098;51.5499;58.8146;49.2672;37.3288;1.51564;70.2676 60.0774;92.543;89.5095;147.467;101.057;85.0816;48.4857;63.3196;26.3528;89.36;131.659;171.379;453.17;118.773;185.461;90.0448;8.55785;103.57 11 7 11 78968;299270;24679;25664;63868;24471;29455;299626;58868;25599;25649 SREBF1_32750;SERPINA6_32325;PRKAR2B_33052;PPARG_32510;HSPD1_8849;HSPB1_8847;GDF15_33113;GADD45B_8679;FZD1_8671;CD74_8252;APOA2_33095 50.202670909090905 41.6322 31.45947044750926 32.58801272727272 31.4864 17.75375393092351 80.41989545454545 89.36 43.58163788569938 41.2009;68.3847;108.746;60.1903;34.4455;41.6322;21.3654;52.5718;25.231;94.9138;3.54778 31.4864;36.9679;59.3814;43.9036;26.6907;30.9494;17.8875;37.1918;13.6792;58.8146;1.51564 60.0774;89.5095;147.467;101.057;48.4857;63.3196;26.3528;89.36;131.659;118.773;8.55785 7 84386;24484;25427;64515;362485;114494;81633 SLPI_9890;IGFBP3_8881;CYP51_8429;CDC20_8255;CCNE2_8227;CCNA2_8221;ACTA2_33040 71.7831 75.1522 19.999032365592118 47.234114285714284 48.098 11.973448798686288 168.74991428571428 103.57 131.92911889631532 53.7429;50.946;75.1522;101.569;77.8893;52.8265;90.3558 37.8192;36.3081;48.098;51.5499;49.2672;37.3288;70.2676 92.543;85.0816;171.379;453.17;185.461;90.0448;103.57 0 Exp 2,5(0.28);Hill,1(0.06);Linear,7(0.39);Poly 2,4(0.23);Power,1(0.06) 1.8018543030051761 34.0243194103241 1.5124053955078125 5.015069484710693 0.803693470092044 1.6567518711090088 45.20150380582868 71.98861619417134 30.416737299766663 46.150700478011125 70.40241125152646 159.13850541514023 UP 0.6111111111111112 0.3888888888888889 0.0 GO:0010038 5 response to metal ion 201 215 5 5 3 5 3 3 93 212 2239 0.031452 0.99074 0.059614 1.4 25664;155423;65155 pparg;anxa7;alas1 PPARG_32510;ANXA7_8051;ALAS1_8018 25664(0.0441) 50.71406666666667 60.1903 27.1843 20.505495808766323 51.32908146081993 19.007070830257927 36.26793333333333 43.3787 21.5215 12.773482377305465 37.32730638946549 12.37841234036854 88.38583333333334 101.057 36.6615 46.69643964033373 86.49677351453035 40.62035697679797 60.1903;64.7676;27.1843 43.9036;43.3787;21.5215 101.057;127.439;36.6615 3 0 3 25664;155423;65155 PPARG_32510;ANXA7_8051;ALAS1_8018 50.71406666666667 60.1903 20.505495808766323 36.26793333333333 43.3787 12.773482377305465 88.38583333333334 101.057 46.69643964033373 60.1903;64.7676;27.1843 43.9036;43.3787;21.5215 101.057;127.439;36.6615 0 0 Exp 2,1(0.34);Linear,2(0.67) 1.6400685122560763 4.93709135055542 1.5239794254302979 1.8392632007598877 0.16947745683039447 1.5738487243652344 27.509913757553026 73.91821957578031 21.813377294841878 50.722489371824786 35.54383742010747 141.22782924655917 UP 1.0 0.0 0.0 GO:0008637 7 apoptotic mitochondrial changes 27 27 2 2 2 2 2 2 94 25 2426 0.92101 0.27078 0.27078 7.41 63868;170465 hspd1;acaa2 HSPD1_8849;ACAA2_7955 56.42215 56.42215 34.4455 31.07967648552667 59.18322911624203 30.833410039642153 35.149550000000005 35.149550000000005 26.6907 11.962620392079627 36.21229405254777 11.867832017792844 73.6292 73.6292 48.4857 35.55827870552795 76.78815246815287 35.27652509967362 0.5 56.42215 34.4455;78.3988 26.6907;43.6084 48.4857;98.7727 1 1 1 63868 HSPD1_8849 34.4455 34.4455 26.6907 26.6907 48.4857 48.4857 34.4455 26.6907 48.4857 1 170465 ACAA2_7955 78.3988 78.3988 43.6084 43.6084 98.7727 98.7727 78.3988 43.6084 98.7727 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.691835987638105 3.384457588195801 1.6557694673538208 1.72868812084198 0.051561274356469455 1.6922287940979004 13.347916000000012 99.49638399999999 18.570204000000004 51.728896000000006 24.34794 122.91046 CONFLICT 0.5 0.5 0.0 GO:0030334 6 regulation of cell migration 259 272 7 7 6 6 6 6 90 266 2185 0.097383 0.95421 0.17849 2.21 25664;24484;24471;25599;502970;81633 pparg;igfbp3;hspb1;cd74;angptl3;acta2 PPARG_32510;IGFBP3_8881;HSPB1_8847;CD74_8252;ANGPTL3_8045;ACTA2_33040 25664(0.0441) 66.0185 59.1316 41.6322 21.662016950967427 66.48796237911026 20.81001427848537 46.719833333333334 41.98965 30.9494 14.899443829709424 46.50958583761852 13.643474224957886 96.1522 102.3135 63.3196 19.347336952045943 98.73362042741897 18.384931896220174 60.1903;50.946;41.6322;94.9138;58.0729;90.3558 43.9036;36.3081;30.9494;58.8146;40.0757;70.2676 101.057;85.0816;63.3196;118.773;105.112;103.57 4 2 4 25664;24471;25599;502970 PPARG_32510;HSPB1_8847;CD74_8252;ANGPTL3_8045 63.702299999999994 59.1316 22.399935525353666 43.435824999999994 41.98965 11.603545194573089 97.06540000000001 103.08449999999999 23.73941558898754 60.1903;41.6322;94.9138;58.0729 43.9036;30.9494;58.8146;40.0757 101.057;63.3196;118.773;105.112 2 24484;81633 IGFBP3_8881;ACTA2_33040 70.65090000000001 70.65090000000001 27.866936825205553 53.287850000000006 53.287850000000006 24.01299273570454 94.32579999999999 94.32579999999999 13.07327301328945 50.946;90.3558 36.3081;70.2676 85.0816;103.57 0 Exp 2,1(0.17);Linear,3(0.5);Poly 2,2(0.34) 1.6469654051245635 9.904783487319946 1.5239794254302979 1.8468482494354248 0.12450259544604059 1.62917959690094 48.68527647906592 83.35172352093409 34.797795287544524 58.64187137912214 80.67110621802593 111.63329378197406 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0007155 3 cell adhesion 145 150 2 2 2 2 2 2 94 148 2303 0.069552 0.98094 0.12244 1.33 29142;502970 vnn1;angptl3 VNN1_10157;ANGPTL3_8045 39.40285 39.40285 20.7328 26.4034379201838 50.99963827837329 20.692282069848364 28.45265 28.45265 16.8296 16.4374749461406 35.67223698551673 12.881991698573415 65.9479 65.9479 26.7838 55.38640137813613 90.27444308976354 43.40612929326633 20.7328;58.0729 16.8296;40.0757 26.7838;105.112 2 0 2 29142;502970 VNN1_10157;ANGPTL3_8045 39.40285 39.40285 26.4034379201838 28.45265 28.45265 16.4374749461406 65.9479 65.9479 55.38640137813613 20.7328;58.0729 16.8296;40.0757 26.7838;105.112 0 0 Linear,2(1) 2.6619549169172902 6.146098256111145 1.5375925302505493 4.608505725860596 2.1714635450511146 3.0730491280555725 2.8095520000000107 75.99614799999999 5.671472000000001 51.233827999999995 -10.813735999999992 142.709536 UP 1.0 0.0 0.0 GO:0007154 3 cell communication 162 169 8 8 6 8 6 6 90 163 2288 0.54417 0.6227 1.0 3.55 78968;24950;25664;25460;58868;25612 srebf1;srd5a1;pparg;hmmr;fzd1;asns SREBF1_32750;SRD5A1_32503;PPARG_32510;HMMR_8814;FZD1_8671;ASNS_8091 25664(0.0441) 47.932199999999995 35.2048 25.231 30.15681042166097 49.259738280570154 26.740874270508964 32.35588333333333 27.331899999999997 13.6792 16.51464988843745 33.95757681620405 15.076099383221958 132.25199999999998 80.5672 35.9474 148.01792599449567 122.8098623915979 131.5478290566678 41.2009;29.2087;60.1903;103.573;25.231;28.1893 31.4864;22.9308;43.9036;58.9579;13.6792;23.1774 60.0774;39.9852;101.057;424.786;131.659;35.9474 4 2 4 78968;25664;58868;25612 SREBF1_32750;PPARG_32510;FZD1_8671;ASNS_8091 38.702875 34.6951 15.916199685933204 28.06165 27.331899999999997 12.824547534968492 82.1852 80.5672 42.54601701436537 41.2009;60.1903;25.231;28.1893 31.4864;43.9036;13.6792;23.1774 60.0774;101.057;131.659;35.9474 2 24950;25460 SRD5A1_32503;HMMR_8814 66.39085 66.39085 52.58350080819076 40.94435 40.94435 25.475006716485883 232.3856 232.3856 272.0952550860084 29.2087;103.573 22.9308;58.9579 39.9852;424.786 0 Exp 2,3(0.5);Linear,2(0.34);Poly 2,1(0.17) 1.8730792563153538 11.700798153877258 1.5124053955078125 3.2609751224517822 0.6725281426365899 1.7260774970054626 23.801726051047627 72.06267394895237 19.141411267588268 45.57035539907841 13.812992119291494 250.69100788070853 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0051179 2 localization 693 737 22 22 18 22 18 18 78 719 1732 0.014082 0.99277 0.028623 2.44 257644;361604;78968;117267;83500;503568;25664;296371;315994;293502;63868;24471;25413;25599;25649;502970;114628;140668 zwint;sytl2;srebf1;slc26a2;slc22a8;slc13a4;pparg;pltp;mapkapk3;kif22;hspd1;hspb1;cpt2;cd74;apoa2;angptl3;abcg5;abcc3 ZWINT_10214;SYTL2_32351;SREBF1_32750;SLC26A2_33072;SLC22A8_9848;SLC13A4_9836;PPARG_32510;PLTP_32412;MAPKAPK3_9194;KIF22_8963;HSPD1_8849;HSPB1_8847;CPT2_8374;CD74_8252;APOA2_33095;ANGPTL3_8045;ABCG5_7947;ABCC3_7941 25664(0.0441) 55.398965555555556 56.40904999999999 3.54778 24.97369360463247 56.78514770895217 24.43456884547029 37.53866888888889 39.212999999999994 1.51564 14.285318954120394 38.44625222874255 13.898478094182945 106.49061944444445 98.19715 8.55785 91.13708010677418 108.47087461864167 90.74628953653765 59.0663;67.0093;41.2009;54.7452;52.4905;65.6237;60.1903;87.0256;104.193;73.9175;34.4455;41.6322;31.2175;94.9138;3.54778;58.0729;33.1119;34.7775 40.5797;44.4373;31.4864;38.3503;37.1479;42.6891;43.9036;56.6266;59.1667;47.5608;26.6907;30.9494;24.8356;58.8146;1.51564;40.0757;24.2098;26.6562 108.188;135.846;60.0774;95.3373;89.1422;135.744;101.057;104.563;434.985;165.416;48.4857;63.3196;42.0237;118.773;8.55785;105.112;50.4329;49.7705 12 6 12 257644;78968;83500;25664;296371;63868;24471;25413;25599;25649;502970;140668 ZWINT_10214;SREBF1_32750;SLC22A8_9848;PPARG_32510;PLTP_32412;HSPD1_8849;HSPB1_8847;CPT2_8374;CD74_8252;APOA2_33095;ANGPTL3_8045;ABCC3_7941 49.88173166666667 47.06135 24.821349342092883 34.940169999999995 34.31715 15.277788385111732 74.92249583333333 76.2309 34.21558196476398 59.0663;41.2009;52.4905;60.1903;87.0256;34.4455;41.6322;31.2175;94.9138;3.54778;58.0729;34.7775 40.5797;31.4864;37.1479;43.9036;56.6266;26.6907;30.9494;24.8356;58.8146;1.51564;40.0757;26.6562 108.188;60.0774;89.1422;101.057;104.563;48.4857;63.3196;42.0237;118.773;8.55785;105.112;49.7705 6 361604;117267;503568;315994;293502;114628 SYTL2_32351;SLC26A2_33072;SLC13A4_9836;MAPKAPK3_9194;KIF22_8963;ABCG5_7947 66.43343333333333 66.31649999999999 23.365456560287157 42.73566666666667 43.5632 11.476913078814643 169.62686666666667 135.79500000000002 135.97647394736586 67.0093;54.7452;65.6237;104.193;73.9175;33.1119 44.4373;38.3503;42.6891;59.1667;47.5608;24.2098 135.846;95.3373;135.744;434.985;165.416;50.4329 0 Exp 2,6(0.34);Hill,1(0.06);Linear,9(0.5);Poly 2,2(0.12) 1.7108574479560743 31.10425877571106 1.5084086656570435 2.5319817066192627 0.267152696502675 1.6539189219474792 43.861707730803204 66.93622338030791 30.939188231693 44.138149546084776 64.38743650189726 148.59380238699163 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0070980 6 biphenyl catabolic process 1 2 1 1 1 1 1 1 95 1 2450 0.99859 0.073976 0.073976 50.0 286954 ugt2b1 UGT2B10_33303,UGT2B1_33224 12.54415 12.54415 12.54415 12.54415 7.348245 7.348245 7.348245 7.348245 25.495849999999997 25.495849999999997 25.495849999999997 25.495849999999997 0.0 12.54415 0.0 12.54415 12.54415 7.348245 25.495849999999997 2 0 1 286954 UGT2B10_33303,UGT2B1_33224 12.54415 12.54415 7.348245 7.348245 25.495849999999997 25.495849999999997 12.54415 7.348245 25.495849999999997 0 0 Exp 4,1(0.5);Poly 2,1(0.5) 1.681894818348241 3.365117907524109 1.635288953781128 1.729828953742981 0.06684987506640222 1.6825589537620544 12.54415 12.54415 7.348245 7.348245 25.495849999999997 25.495849999999997 UP 1.0 0.0 0.0 GO:0032870 5 cellular response to hormone stimulus 198 212 15 15 11 15 11 11 85 201 2250 0.90238 0.1703 0.25661 5.19 286954;78968;24950;25664;24614;24484;58868;25315;114494;25612;65155 ugt2b1;srebf1;srd5a1;pparg;orm1;igfbp3;fzd1;ephx1;ccna2;asns;alas1 UGT2B10_33303,UGT2B1_33224;SREBF1_32750;SRD5A1_32503;PPARG_32510;ORM1_9400;IGFBP3_8881;FZD1_8671;EPHX1_8567;CCNA2_8221;ASNS_8091;ALAS1_8018 25664(0.0441) 35.07149545454545 29.2087 12.54415 14.498995536285515 36.326856033358105 15.212332693810355 25.777749545454547 23.1774 7.348245 10.77671746511906 26.78003206638593 11.297613495386857 62.33962272727272 48.3681 25.495849999999997 34.58651038147219 63.13437106101892 33.92894420629345 9.5 56.5084 12.54415;41.2009;29.2087;60.1903;24.2519;50.946;25.231;34.0134;52.8265;28.1893;27.1843 7.348245;31.4864;22.9308;43.9036;19.7133;36.3081;13.6792;26.1579;37.3288;23.1774;21.5215 25.495849999999997;60.0774;39.9852;101.057;31.358;85.0816;131.659;48.3681;90.0448;35.9474;36.6615 9 3 8 286954;78968;25664;24614;58868;25315;25612;65155 UGT2B10_33303,UGT2B1_33224;SREBF1_32750;PPARG_32510;ORM1_9400;FZD1_8671;EPHX1_8567;ASNS_8091;ALAS1_8018 31.60065625 27.686799999999998 14.163446240371153 23.373443125 22.349449999999997 11.101548857892027 58.82803125 42.514799999999994 37.94567961967792 12.54415;41.2009;60.1903;24.2519;25.231;34.0134;28.1893;27.1843 7.348245;31.4864;43.9036;19.7133;13.6792;26.1579;23.1774;21.5215 25.495849999999997;60.0774;101.057;31.358;131.659;48.3681;35.9474;36.6615 3 24950;24484;114494 SRD5A1_32503;IGFBP3_8881;CCNA2_8221 44.32706666666667 50.946 13.126607637288968 32.189233333333334 36.3081 8.034263996367907 71.70386666666667 85.0816 27.581038774733106 29.2087;50.946;52.8265 22.9308;36.3081;37.3288 39.9852;85.0816;90.0448 0 Exp 2,4(0.34);Exp 4,1(0.09);Linear,5(0.42);Poly 2,2(0.17) 2.0053646085222105 25.014371871948242 1.5124053955078125 3.5849626064300537 0.6672386551659171 1.8759093284606934 26.50313664176747 43.63985426732343 19.409116502290818 32.14638258861827 41.90030123850663 82.77894421603881 UP 0.7272727272727273 0.2727272727272727 0.0 GO:0009896 6 positive regulation of catabolic process 120 128 7 7 4 7 4 4 92 124 2327 0.46518 0.72175 1.0 3.12 24484;64515;25649;502970 igfbp3;cdc20;apoa2;angptl3 IGFBP3_8881;CDC20_8255;APOA2_33095;ANGPTL3_8045 53.533919999999995 54.50945 3.54778 40.13843865121812 52.34985001905059 37.19594268113863 32.362335 38.191900000000004 1.51564 21.561897752831648 32.5499142148439 20.642543298713328 162.9803625 95.0968 8.55785 197.88321695439197 145.8296612476187 178.7080535361625 50.946;101.569;3.54778;58.0729 36.3081;51.5499;1.51564;40.0757 85.0816;453.17;8.55785;105.112 2 2 2 25649;502970 APOA2_33095;ANGPTL3_8045 30.81034 30.81034 38.55508209701024 20.795669999999998 20.795669999999998 27.266079908960144 56.834925 56.834925 68.27409421670308 3.54778;58.0729 1.51564;40.0757 8.55785;105.112 2 24484;64515 IGFBP3_8881;CDC20_8255 76.2575 76.2575 35.79586658400661 43.929 43.929 10.77758013748912 269.1258 269.1258 260.27780371610635 50.946;101.569 36.3081;51.5499 85.0816;453.17 0 Exp 2,1(0.25);Hill,1(0.25);Linear,2(0.5) 1.6297659146488175 6.531190872192383 1.5293418169021606 1.7380040884017944 0.1148467327284189 1.6319224834442139 14.198250121806254 92.86958987819375 11.23167520222498 53.492994797775026 -30.94519011530417 356.90591511530414 CONFLICT 0.5 0.5 0.0 GO:0009062 6 fatty acid catabolic process 37 42 13 13 11 13 11 11 85 31 2420 1.0 1.9961E-7 1.9961E-7 26.19 364975;171142;291075;29740;64526;117543;311849;25413;50681;192272;170465 gcdh;ehhadh;eci2;eci1;ech1;decr1;crat;cpt2;acox1;acot2;acaa2 GCDH_8693;EHHADH_8534;ECI2_8521;ECI1_8520;ECH1_8516;DECR1_8458;CRAT_8375;CPT2_8374;ACOX1_7973;ACOT2_7969;ACAA2_7955 21.020882727272728 13.6362 7.29984 20.442957535400833 22.536485993158923 22.785140686872122 14.01201909090909 10.4227 1.97988 11.992959502435966 14.622088593798342 12.998372944746233 31.618818181818177 28.0829 11.8779 23.95366145835823 33.48864110660387 26.689377490954264 1.5 8.857145 3.5 10.81984 15.9021;7.29984;8.72912;11.7653;9.87438;21.6199;8.98517;31.2175;23.8014;13.6362;78.3988 10.4227;5.26587;5.10151;8.40998;6.59127;17.4928;1.97988;24.8356;19.0993;11.3249;43.6084 31.2818;11.8779;17.7951;18.8402;19.44;28.0829;31.3726;42.0237;31.3543;16.9658;98.7727 10 1 10 364975;171142;291075;29740;64526;117543;311849;25413;50681;192272 GCDH_8693;EHHADH_8534;ECI2_8521;ECI1_8520;ECH1_8516;DECR1_8458;CRAT_8375;CPT2_8374;ACOX1_7973;ACOT2_7969 15.283091000000002 12.70075 7.871871147958049 11.052381 9.41634 7.26307584875635 24.903429999999997 23.76145 9.292594094468756 15.9021;7.29984;8.72912;11.7653;9.87438;21.6199;8.98517;31.2175;23.8014;13.6362 10.4227;5.26587;5.10151;8.40998;6.59127;17.4928;1.97988;24.8356;19.0993;11.3249 31.2818;11.8779;17.7951;18.8402;19.44;28.0829;31.3726;42.0237;31.3543;16.9658 1 170465 ACAA2_7955 78.3988 78.3988 43.6084 43.6084 98.7727 98.7727 78.3988 43.6084 98.7727 0 Exp 2,1(0.1);Hill,4(0.37);Linear,3(0.28);Poly 2,3(0.28) 2.2848661650494497 27.39775586128235 1.5464483499526978 4.473705768585205 1.131090470722882 1.8691840171813965 8.93986684452886 33.1018986100166 6.924632934618668 21.099405247199517 17.4631088610327 45.77452750260366 UP 0.9090909090909091 0.09090909090909091 0.0 GO:0010033 4 response to organic substance 795 856 41 39 31 39 28 28 68 828 1623 0.20459 0.85329 0.37961 3.27 286954;360243;78968;24950;84386;83500;24679;25664;24614;291234;24552;315994;24484;63868;24471;58868;25315;65210;25086;25413;114494;25612;25649;155423;502970;65155;192272;140668 ugt2b1;top2a;srebf1;srd5a1;slpi;slc22a8;prkar2b;pparg;orm1;mki67;me1;mapkapk3;igfbp3;hspd1;hspb1;fzd1;ephx1;cyp2j4;cyp2e1;cpt2;ccna2;asns;apoa2;anxa7;angptl3;alas1;acot2;abcc3 UGT2B10_33303,UGT2B1_33224;TOP2A_10059;SREBF1_32750;SRD5A1_32503;SLPI_9890;SLC22A8_9848;PRKAR2B_33052;PPARG_32510;ORM1_9400;MKI67_9232;ME1_9215;MAPKAPK3_9194;IGFBP3_8881;HSPD1_8849;HSPB1_8847;FZD1_8671;EPHX1_8567;CYP2J4_32580;CYP2E1_8421;CPT2_8374;CCNA2_8221;ASNS_8091;APOA2_33095;ANXA7_8051;ANGPTL3_8045;ALAS1_8018;ACOT2_7969;ABCC3_7941 25664(0.0441) 41.61918107142858 37.9892 3.54778 24.786397379327692 41.633782648823306 23.95374403250528 28.02926625 26.67345 1.51564 14.77273974085205 28.31874124335839 14.711271472044873 83.77962142857145 61.698499999999996 8.55785 83.12501255984802 84.78440522273101 86.69091959883171 12.54415;54.9577;41.2009;29.2087;53.7429;52.4905;108.746;60.1903;24.2519;49.7822;49.3339;104.193;50.946;34.4455;41.6322;25.231;34.0134;16.3155;7.89174;31.2175;52.8265;28.1893;3.54778;64.7676;58.0729;27.1843;13.6362;34.7775 7.348245;18.8326;31.4864;22.9308;37.8192;37.1479;59.3814;43.9036;19.7133;35.6665;35.4173;59.1667;36.3081;26.6907;30.9494;13.6792;26.1579;8.2378;4.16797;24.8356;37.3288;23.1774;1.51564;43.3787;40.0757;21.5215;11.3249;26.6562 25.495849999999997;218.525;60.0774;39.9852;92.543;89.1422;147.467;101.057;31.358;82.1147;80.9924;434.985;85.0816;48.4857;63.3196;131.659;48.3681;36.8422;15.8079;42.0237;90.0448;35.9474;8.55785;127.439;105.112;36.6615;16.9658;49.7705 22 7 21 286954;78968;83500;24679;25664;24614;24552;63868;24471;58868;25315;65210;25086;25413;25612;25649;155423;502970;65155;192272;140668 UGT2B10_33303,UGT2B1_33224;SREBF1_32750;SLC22A8_9848;PRKAR2B_33052;PPARG_32510;ORM1_9400;ME1_9215;HSPD1_8849;HSPB1_8847;FZD1_8671;EPHX1_8567;CYP2J4_32580;CYP2E1_8421;CPT2_8374;ASNS_8091;APOA2_33095;ANXA7_8051;ANGPTL3_8045;ALAS1_8018;ACOT2_7969;ABCC3_7941 36.65143190476191 34.0134 23.870470531894764 25.560321666666667 26.1579 14.790200917410937 62.026195238095234 48.4857 40.673260854832215 12.54415;41.2009;52.4905;108.746;60.1903;24.2519;49.3339;34.4455;41.6322;25.231;34.0134;16.3155;7.89174;31.2175;28.1893;3.54778;64.7676;58.0729;27.1843;13.6362;34.7775 7.348245;31.4864;37.1479;59.3814;43.9036;19.7133;35.4173;26.6907;30.9494;13.6792;26.1579;8.2378;4.16797;24.8356;23.1774;1.51564;43.3787;40.0757;21.5215;11.3249;26.6562 25.495849999999997;60.0774;89.1422;147.467;101.057;31.358;80.9924;48.4857;63.3196;131.659;48.3681;36.8422;15.8079;42.0237;35.9474;8.55785;127.439;105.112;36.6615;16.9658;49.7705 7 360243;24950;84386;291234;315994;24484;114494 TOP2A_10059;SRD5A1_32503;SLPI_9890;MKI67_9232;MAPKAPK3_9194;IGFBP3_8881;CCNA2_8221 56.52242857142857 52.8265 22.799431382508537 35.436099999999996 36.3081 12.943950091065723 149.03990000000002 90.0448 137.6757513118293 54.9577;29.2087;53.7429;49.7822;104.193;50.946;52.8265 18.8326;22.9308;37.8192;35.6665;59.1667;36.3081;37.3288 218.525;39.9852;92.543;82.1147;434.985;85.0816;90.0448 0 Exp 2,7(0.25);Exp 4,3(0.11);Hill,1(0.04);Linear,15(0.52);Poly 2,2(0.07);Power,1(0.04) 1.9096796568873733 57.58644258975983 1.5124053955078125 4.473705768585205 0.6729633113759228 1.8061060905456543 32.43817100061919 50.80019114223796 22.557366874767467 33.501165625232545 52.98968589382446 114.56955696331843 UP 0.75 0.25 0.0 GO:0016043 4 cellular component organization 805 877 36 35 28 35 27 27 69 850 1601 0.11079 0.92628 0.22811 3.08 257644;360243;25123;64159;308761;313245;296371;54133;304951;338475;362094;316273;25626;293502;303575;63868;25460;102551184;64515;25599;362485;114494;25649;155423;50681;170465;114628 zwint;top2a;tagln;sptan1;prc1;polr1e;pltp;pdlim1;nuf2;nrep;mrps2;mcm3;krt8;kif22;kif18b;hspd1;hmmr;loc102551184;cdc20;cd74;ccne2;ccna2;apoa2;anxa7;acox1;acaa2;abcg5 ZWINT_10214;TOP2A_10059;TAGLN_9981;SPTAN1_9932;PRC1_9556;POLR1E_9523;PLTP_32412;PDLIM1_9452;NUF2_33136;NREP_9364;MRPS2_9250;MCM3_9207;KRT8_8978;KIF22_8963;KIF18B_32882;HSPD1_8849;HMMR_8814;HIST1H4A_32934;CDC20_8255;CD74_8252;CCNE2_8227;CCNA2_8221;APOA2_33095;ANXA7_8051;ACOX1_7973;ACAA2_7955;ABCG5_7947 60.691199259259285 64.7676 5.73955E-13 25.76153644220264 62.763913450936265 24.163744105856047 38.66196814814817 43.3787 5.73955E-13 15.243216040122634 39.972219034694675 14.441292133139182 134.4196055555556 111.753 5.73957E-13 103.06487757722007 132.82784964422646 94.30822104613408 59.0663;54.9577;45.9044;47.5519;80.3005;73.982;87.0256;67.1147;5.73955E-13;69.4104;63.3158;54.0045;68.9539;73.9175;65.9823;34.4455;103.573;58.3303;101.569;94.9138;77.8893;52.8265;3.54778;64.7676;23.8014;78.3988;33.1119 40.5797;18.8326;35.0852;34.4152;50.2731;47.589;56.6266;47.2419;5.73955E-13;43.1468;45.3429;33.259;45.3374;47.5608;43.9552;26.6907;58.9579;40.2068;51.5499;58.8146;49.2672;37.3288;1.51564;43.3787;19.0993;43.6084;24.2098 108.188;218.525;67.7714;76.6397;198.961;165.722;104.563;123.914;5.73957E-13;157.944;111.245;111.753;143.578;165.416;131.93;48.4857;424.786;105.902;453.17;118.773;185.461;90.0448;8.55785;127.439;31.3543;98.7727;50.4329 13 14 13 257644;25123;64159;313245;296371;54133;362094;25626;63868;25599;25649;155423;50681 ZWINT_10214;TAGLN_9981;SPTAN1_9932;POLR1E_9523;PLTP_32412;PDLIM1_9452;MRPS2_9250;KRT8_8978;HSPD1_8849;CD74_8252;APOA2_33095;ANXA7_8051;ACOX1_7973 56.49159076923077 63.3158 25.25551038057719 38.593603076923074 43.3787 15.636260433101947 95.09468846153845 108.188 45.74307105898734 59.0663;45.9044;47.5519;73.982;87.0256;67.1147;63.3158;68.9539;34.4455;94.9138;3.54778;64.7676;23.8014 40.5797;35.0852;34.4152;47.589;56.6266;47.2419;45.3429;45.3374;26.6907;58.8146;1.51564;43.3787;19.0993 108.188;67.7714;76.6397;165.722;104.563;123.914;111.245;143.578;48.4857;118.773;8.55785;127.439;31.3543 14 360243;308761;304951;338475;316273;293502;303575;25460;102551184;64515;362485;114494;170465;114628 TOP2A_10059;PRC1_9556;NUF2_33136;NREP_9364;MCM3_9207;KIF22_8963;KIF18B_32882;HMMR_8814;HIST1H4A_32934;CDC20_8255;CCNE2_8227;CCNA2_8221;ACAA2_7955;ABCG5_7947 64.59083571428576 67.69635 26.542865982858842 38.72545000000004 43.3776 15.460166319124658 170.93560000000005 144.937 127.79212774589463 54.9577;80.3005;5.73955E-13;69.4104;54.0045;73.9175;65.9823;103.573;58.3303;101.569;77.8893;52.8265;78.3988;33.1119 18.8326;50.2731;5.73955E-13;43.1468;33.259;47.5608;43.9552;58.9579;40.2068;51.5499;49.2672;37.3288;43.6084;24.2098 218.525;198.961;5.73957E-13;157.944;111.753;165.416;131.93;424.786;105.902;453.17;185.461;90.0448;98.7727;50.4329 0 Exp 2,9(0.34);Hill,2(0.08);Linear,13(0.49);Poly 2,3(0.12) 1.7397397558002599 47.55943262577057 1.5062377452850342 2.5474231243133545 0.30308887213506563 1.6557694673538208 50.97389165949184 70.40850685902673 32.91219389054896 44.41174240574739 95.54330947759574 173.29590163351543 CONFLICT 0.48148148148148145 0.5185185185185185 0.0 GO:1901360 4 organic cyclic compound metabolic process 507 567 43 41 36 43 34 34 62 533 1918 0.99911 0.0018762 0.0025449 6.0 286954;360243;360268;64305;78968;24950;299270;298490;313245;296371;680308;291234;316273;293502;63868;364975;65030;25315;114027;25427;266682;25086;24894;362485;25649;502970;65155;26760;24763;681337;314304;192272;50559;170465 ugt2b1;top2a;sult1e1;sult1b1;srebf1;srd5a1;serpina6;ppcs;polr1e;pltp;mthfd2;mki67;mcm3;kif22;hspd1;gcdh;ephx2;ephx1;dao;cyp51;cyp3a2;cyp2e1;cyp2a1;ccne2;apoa2;angptl3;alas1;akr7a3;acsm3;acot4;acot3;acot2;acot1;acaa2 UGT2B10_33303,UGT2B1_33224;TOP2A_10059;SULT1E1_32446;SULT1B1_32942;SREBF1_32750;SRD5A1_32503;SERPINA6_32325;PPCS_9540;POLR1E_9523;PLTP_32412;MTHFD2_9261;MKI67_9232;MCM3_9207;KIF22_8963;HSPD1_8849;GCDH_8693;EPHX2_33282;EPHX1_8567;DAO_8437;CYP51_8429;CYP3A2_32374;CYP2E1_8421;CYP2A1_32717;CCNE2_8227;APOA2_33095;ANGPTL3_8045;ALAS1_8018;AKR7A3_8015;ACSM3_7976;ACOT4_7971;ACOT3_7970;ACOT2_7969;ACOT1_7968;ACAA2_7955 38.42172029411764 32.4486 3.54778 25.779352414373836 38.588236974226845 25.60062367083169 25.50446455882353 24.714199999999998 1.51564 17.014381705731772 25.288737261577026 16.752345359948325 69.76851764705881 48.4269 8.55785 55.929933952137276 67.57273103301449 49.95328982405365 27.5 71.1511 12.54415;54.9577;59.2729;15.4629;41.2009;29.2087;68.3847;15.1091;73.982;87.0256;57.4184;49.7822;54.0045;73.9175;34.4455;15.9021;6.44145;34.0134;6.1336;75.1522;23.2485;7.89174;9.37187;77.8893;3.54778;58.0729;27.1843;18.819;52.2057;12.3157;30.8838;13.6362;28.5134;78.3988 7.348245;18.8326;45.3114;7.69418;31.4864;22.9308;36.9679;7.94061;47.589;56.6266;46.387;35.6665;33.259;47.5608;26.6907;10.4227;2.66377;26.1579;2.43617;48.098;18.6955;4.16797;4.95906;49.2672;1.51564;40.0757;21.5215;11.5469;42.2655;6.70485;24.6874;11.3249;24.741;43.6084 25.495849999999997;218.525;91.5578;35.0879;60.0774;39.9852;89.5095;30.6311;165.722;104.563;79.7903;82.1147;111.753;165.416;48.4857;31.2818;17.3473;48.3681;16.2027;171.379;30.5145;15.8079;19.1079;185.461;8.55785;105.112;36.6615;51.6405;71.1126;24.3993;41.2585;16.9658;33.4642;98.7727 27 8 26 286954;360268;64305;78968;299270;298490;313245;296371;680308;63868;364975;65030;25315;114027;266682;25086;24894;25649;502970;65155;26760;24763;681337;314304;192272;50559 UGT2B10_33303,UGT2B1_33224;SULT1E1_32446;SULT1B1_32942;SREBF1_32750;SERPINA6_32325;PPCS_9540;POLR1E_9523;PLTP_32412;MTHFD2_9261;HSPD1_8849;GCDH_8693;EPHX2_33282;EPHX1_8567;DAO_8437;CYP3A2_32374;CYP2E1_8421;CYP2A1_32717;APOA2_33095;ANGPTL3_8045;ALAS1_8018;AKR7A3_8015;ACSM3_7976;ACOT4_7971;ACOT3_7970;ACOT2_7969;ACOT1_7968 31.27029192307692 25.2164 23.75383933780997 21.843403653846153 20.1085 16.853187707417938 49.95088461538462 35.8747 37.08811601487939 12.54415;59.2729;15.4629;41.2009;68.3847;15.1091;73.982;87.0256;57.4184;34.4455;15.9021;6.44145;34.0134;6.1336;23.2485;7.89174;9.37187;3.54778;58.0729;27.1843;18.819;52.2057;12.3157;30.8838;13.6362;28.5134 7.348245;45.3114;7.69418;31.4864;36.9679;7.94061;47.589;56.6266;46.387;26.6907;10.4227;2.66377;26.1579;2.43617;18.6955;4.16797;4.95906;1.51564;40.0757;21.5215;11.5469;42.2655;6.70485;24.6874;11.3249;24.741 25.495849999999997;91.5578;35.0879;60.0774;89.5095;30.6311;165.722;104.563;79.7903;48.4857;31.2818;17.3473;48.3681;16.2027;30.5145;15.8079;19.1079;8.55785;105.112;36.6615;51.6405;71.1126;24.3993;41.2585;16.9658;33.4642 8 360243;24950;291234;316273;293502;25427;362485;170465 TOP2A_10059;SRD5A1_32503;MKI67_9232;MCM3_9207;KIF22_8963;CYP51_8429;CCNE2_8227;ACAA2_7955 61.6638625 64.4376 17.621252435376153 37.4029125 39.63745 11.779659550190447 134.175825 138.5845 60.28903735574273 54.9577;29.2087;49.7822;54.0045;73.9175;75.1522;77.8893;78.3988 18.8326;22.9308;35.6665;33.259;47.5608;48.098;49.2672;43.6084 218.525;39.9852;82.1147;111.753;165.416;171.379;185.461;98.7727 0 Exp 2,9(0.26);Exp 4,5(0.15);Hill,4(0.12);Linear,11(0.32);Poly 2,6(0.18) 2.1331525772255353 119.52499008178711 1.5084086656570435 50.888092041015625 8.285700870511416 1.8061060905456543 29.756320262805396 47.0871203254299 19.785297475192664 31.2236316424544 50.968384748844 88.5686505452736 UP 0.7647058823529411 0.23529411764705882 0.0 GO:0031647 4 regulation of protein stability 60 71 4 4 3 4 3 3 93 68 2383 0.72193 0.50597 0.7488 4.23 78968;63868;25649 srebf1;hspd1;apoa2 SREBF1_32750;HSPD1_8849;APOA2_33095 26.39806 34.4455 3.54778 20.075117168993064 28.260597765790507 19.884180340407596 19.89758 26.6907 1.51564 16.098803472469623 21.34285958316987 15.90322678449132 39.04031666666666 48.4857 8.55785 27.027346480663496 41.739214714103575 26.940442248820485 41.2009;34.4455;3.54778 31.4864;26.6907;1.51564 60.0774;48.4857;8.55785 3 0 3 78968;63868;25649 SREBF1_32750;HSPD1_8849;APOA2_33095 26.39806 34.4455 20.075117168993064 19.89758 26.6907 16.098803472469623 39.04031666666666 48.4857 27.027346480663496 41.2009;34.4455;3.54778 31.4864;26.6907;1.51564 60.0774;48.4857;8.55785 0 0 Exp 2,2(0.67);Hill,1(0.34) 1.7615950058849068 5.294577360153198 1.6557694673538208 1.912555456161499 0.1326748582630064 1.7262524366378784 3.6809263689984135 49.11519363100159 1.6800689038160073 38.11509109618399 8.455994965125655 69.62463836820767 UP 1.0 0.0 0.0 GO:0090181 6 regulation of cholesterol metabolic process 18 18 4 4 3 4 3 3 93 15 2436 0.99614 0.028069 0.028069 16.67 78968;65030;25427 srebf1;ephx2;cyp51 SREBF1_32750;EPHX2_33282;CYP51_8429 40.93151666666666 41.2009 6.44145 34.35616708723244 30.796255473508793 26.78281446919509 27.416056666666666 31.4864 2.66377 22.9889774688139 21.74666350936674 19.694981248223232 82.93456666666667 60.0774 17.3473 79.51904616029628 53.99073114009884 53.03542662814641 0.0 6.44145 0.5 23.821174999999997 41.2009;6.44145;75.1522 31.4864;2.66377;48.098 60.0774;17.3473;171.379 2 1 2 78968;65030 SREBF1_32750;EPHX2_33282 23.821174999999997 23.821174999999997 24.578642805314743 17.075085 17.075085 20.380677124630818 38.71235 38.71235 30.214743470779293 41.2009;6.44145 31.4864;2.66377 60.0774;17.3473 1 25427 CYP51_8429 75.1522 75.1522 48.098 48.098 171.379 171.379 75.1522 48.098 171.379 0 Exp 2,1(0.34);Exp 4,1(0.34);Linear,1(0.34) 1.9501982803077258 5.920122027397156 1.633623480796814 2.3739430904388428 0.37388828999346296 1.912555456161499 2.0538537270373496 79.80917960629598 1.4015796998393313 53.43053363349401 -7.049705037778054 172.9188383711114 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0035556 5 intracellular signal transduction 318 334 9 9 5 9 5 5 91 329 2122 0.0088273 0.99718 0.019416 1.5 315994;25685;24471;25599;114494 mapkapk3;igfbp1;hspb1;cd74;ccna2 MAPKAPK3_9194;IGFBP1_32306;HSPB1_8847;CD74_8252;CCNA2_8221 78.48052 94.9138 41.6322 28.98923117981917 79.8566528538336 29.09047967831031 48.717499999999994 57.328 30.9494 13.515600103214066 49.591418353396875 13.7992497442762 212.90627999999998 118.773 63.3196 170.68405495901484 201.98116533627007 174.09831870568007 104.193;98.8371;41.6322;94.9138;52.8265 59.1667;57.328;30.9494;58.8146;37.3288 434.985;357.409;63.3196;118.773;90.0448 3 2 3 25685;24471;25599 IGFBP1_32306;HSPB1_8847;CD74_8252 78.46103333333333 94.9138 31.95497291883274 49.03066666666666 57.328 15.676467972516468 179.8338666666667 118.773 156.2640901699854 98.8371;41.6322;94.9138 57.328;30.9494;58.8146 357.409;63.3196;118.773 2 315994;114494 MAPKAPK3_9194;CCNA2_8221 78.50975 78.50975 36.321600475818805 48.247749999999996 48.247749999999996 15.44172717687371 262.5149 262.5149 243.90955452384392 104.193;52.8265 59.1667;37.3288 434.985;90.0448 0 Linear,4(0.8);Poly 2,1(0.2) 1.854555941153472 9.378499269485474 1.5163835287094116 2.3255980014801025 0.3179101530015882 1.8468482494354248 53.07033851885542 103.89070148114457 36.870554169703986 60.564445830296 63.29510937104243 362.51745062895753 UP 0.6 0.4 0.0 GO:0045766 7 positive regulation of angiogenesis 68 69 2 2 2 2 2 2 94 67 2384 0.51338 0.74285 1.0 2.9 24471;502970 hspb1;angptl3 HSPB1_8847;ANGPTL3_8045 49.852549999999994 49.852549999999994 41.6322 11.625330457453689 52.024745096037265 11.21211153951403 35.51255 35.51255 30.9494 6.453268617142801 36.71834440686619 6.223889101015584 84.2158 84.2158 63.3196 29.551689442060653 89.73753851062473 28.501283418831576 41.6322;58.0729 30.9494;40.0757 63.3196;105.112 2 0 2 24471;502970 HSPB1_8847;ANGPTL3_8045 49.852549999999994 49.852549999999994 11.625330457453689 35.51255 35.51255 6.453268617142801 84.2158 84.2158 29.551689442060653 41.6322;58.0729 30.9494;40.0757 63.3196;105.112 0 0 Linear,2(1) 1.685140965272108 3.384440779685974 1.5375925302505493 1.8468482494354248 0.21867681615634815 1.692220389842987 33.740663999999995 65.96443599999999 26.568776 44.456323999999995 43.259248000000014 125.17235199999999 UP 1.0 0.0 0.0 GO:0001890 5 placenta development 22 23 2 2 2 2 2 2 94 21 2430 0.94677 0.21415 0.21415 8.7 25664;50549 pparg;cyp4a1 PPARG_32510;CYP4A1_33111 25664(0.0441) 41.69915 41.69915 23.208 26.15043511387525 55.190362004662006 17.883502283823713 31.3833 31.3833 18.863 17.706378064979855 40.51815757575758 12.108863626337882 65.52115 65.52115 29.9853 50.25528102045594 91.4482386946387 34.368087146154565 0.5 41.69915 60.1903;23.208 43.9036;18.863 101.057;29.9853 2 0 2 25664;50549 PPARG_32510;CYP4A1_33111 41.69915 41.69915 26.15043511387525 31.3833 31.3833 17.706378064979855 65.52115 65.52115 50.25528102045594 60.1903;23.208 43.9036;18.863 101.057;29.9853 0 0 Exp 2,2(1) 1.7643025855334127 3.566502809524536 1.5239794254302979 2.0425233840942383 0.3666659495145891 1.783251404762268 5.456496000000001 77.941804 6.843512000000008 55.92308799999999 -4.129115999999996 135.17141600000002 UP 1.0 0.0 0.0 GO:0006084 8 acetyl-CoA metabolic process 16 16 2 2 2 2 2 2 94 14 2437 0.97966 0.11985 0.11985 12.5 298490;170465 ppcs;acaa2 PPCS_9540;ACAA2_7955 46.753949999999996 46.753949999999996 15.1091 44.75257604926224 53.052861284030186 43.85704614217464 25.774505 25.774505 7.94061 25.22093617893773 29.324343992875924 24.716247854222644 64.7019 64.7019 30.6311 48.18338744090127 71.48369692986175 47.21920463205877 0.0 15.1091 0.5 46.753949999999996 15.1091;78.3988 7.94061;43.6084 30.6311;98.7727 1 1 1 298490 PPCS_9540 15.1091 15.1091 7.94061 7.94061 30.6311 30.6311 15.1091 7.94061 30.6311 1 170465 ACAA2_7955 78.3988 78.3988 43.6084 43.6084 98.7727 98.7727 78.3988 43.6084 98.7727 0 Hill,1(0.5);Poly 2,1(0.5) 1.8132243515931556 3.6305826902389526 1.72868812084198 1.9018945693969727 0.1224754543184742 1.8152913451194763 -15.269955999999993 108.77785599999999 -9.1799292 60.7289392 -2.0768679999999904 131.48066799999998 CONFLICT 0.5 0.5 0.0 GO:0048870 3 cell motility 193 205 3 3 2 3 2 2 94 203 2248 0.012837 0.99736 0.021321 0.98 296371;54133 pltp;pdlim1 PLTP_32412;PDLIM1_9452 77.07015 77.07015 67.1147 14.079132409527228 76.30635996975873 14.037635804664873 51.934250000000006 51.934250000000006 47.2419 6.635985009401365 51.57424918151337 6.616426215592474 114.2385 114.2385 104.563 13.683223322740849 114.98081204391556 13.6428936138535 87.0256;67.1147 56.6266;47.2419 104.563;123.914 2 0 2 296371;54133 PLTP_32412;PDLIM1_9452 77.07015 77.07015 14.079132409527228 51.934250000000006 51.934250000000006 6.635985009401365 114.2385 114.2385 13.683223322740849 87.0256;67.1147 56.6266;47.2419 104.563;123.914 0 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.5708939820667203 3.1443763971328735 1.5084086656570435 1.63596773147583 0.09019788044228516 1.5721881985664368 57.557468 96.582832 42.737244000000004 61.13125600000001 95.27452 133.20248 UP 1.0 0.0 0.0 GO:0000070 6 mitotic sister chromatid segregation 13 13 2 2 2 2 2 2 94 11 2440 0.98873 0.083726 0.083726 15.38 257644;303575 zwint;kif18b ZWINT_10214;KIF18B_32882 62.5243 62.5243 59.0663 4.890350498686115 62.713057216014896 4.88305943306079 42.26745 42.26745 40.5797 2.38683893989532 42.3595769494879 2.38328038118801 120.059 120.059 108.188 16.78812919893105 120.70698638268158 16.76309963269655 0.0 59.0663 0.5 62.5243 59.0663;65.9823 40.5797;43.9552 108.188;131.93 1 1 1 257644 ZWINT_10214 59.0663 59.0663 40.5797 40.5797 108.188 108.188 59.0663 40.5797 108.188 1 303575 KIF18B_32882 65.9823 65.9823 43.9552 43.9552 131.93 131.93 65.9823 43.9552 131.93 0 Linear,2(1) 1.6437275639952664 3.2911226749420166 1.5678966045379639 1.7232260704040527 0.10983451863199581 1.6455613374710083 55.74662 69.30197999999999 38.95946 45.57543999999999 96.79184 143.32616 CONFLICT 0.5 0.5 0.0 GO:0006690 6 icosanoid metabolic process 39 48 11 11 11 11 11 11 85 37 2414 1.0 8.7305E-7 8.7305E-7 22.92 25315;50549;65210;25086;24303;499353;171521;29277;24894;25599;50681 ephx1;cyp4a1;cyp2j4;cyp2e1;cyp2d3;cyp2c24;cyp2c13;cyp2c11;cyp2a1;cd74;acox1 EPHX1_8567;CYP4A1_33111;CYP2J4_32580;CYP2E1_8421;CYP2D3_8420;CYP2C24_32875;CYP2C13_8419;CYP2C11_32593;CYP2A1_32717;CD74_8252;ACOX1_7973 40.02964636363636 23.8014 7.89174 34.07325529475993 45.669085067046595 36.737090952994016 26.41040272727273 19.0993 4.16797 20.137612140421265 29.225470996899094 21.579763643217166 53.31535454545454 36.8422 15.8079 36.542511551243 60.362866098167395 38.1923249913131 1.5 11.088885 3.5 19.76175 34.0134;23.208;16.3155;7.89174;12.8059;58.9435;104.635;54.426;9.37187;94.9138;23.8014 26.1579;18.863;8.2378;4.16797;8.8664;48.1505;49.2461;43.9518;4.95906;58.8146;19.0993 48.3681;29.9853;36.8422;15.8079;22.6004;80.4167;108.327;74.8861;19.1079;118.773;31.3543 11 0 11 25315;50549;65210;25086;24303;499353;171521;29277;24894;25599;50681 EPHX1_8567;CYP4A1_33111;CYP2J4_32580;CYP2E1_8421;CYP2D3_8420;CYP2C24_32875;CYP2C13_8419;CYP2C11_32593;CYP2A1_32717;CD74_8252;ACOX1_7973 40.02964636363636 23.8014 34.07325529475993 26.41040272727273 19.0993 20.137612140421265 53.31535454545454 36.8422 36.542511551243 34.0134;23.208;16.3155;7.89174;12.8059;58.9435;104.635;54.426;9.37187;94.9138;23.8014 26.1579;18.863;8.2378;4.16797;8.8664;48.1505;49.2461;43.9518;4.95906;58.8146;19.0993 48.3681;29.9853;36.8422;15.8079;22.6004;80.4167;108.327;74.8861;19.1079;118.773;31.3543 0 0 Exp 2,3(0.28);Exp 4,3(0.28);Linear,2(0.19);Poly 2,2(0.19);Power,1(0.1) 1.9812662511815344 22.36474096775055 1.5310101509094238 2.9415390491485596 0.502117411620549 1.940477728843689 19.89363924823 60.16565347904272 14.50983444170666 38.3109710128388 31.72011023300963 74.91059885789946 UP 1.0 0.0 0.0 GO:0050794 4 regulation of cellular process 1555 1680 62 61 47 61 46 46 50 1634 817 1.5863E-4 0.99993 2.5059E-4 2.74 257644;29142;365813;360243;361604;360268;78968;64159;84386;299270;309607;24679;308761;25664;363465;54133;24614;338475;65035;259241;291234;315994;25626;303575;24484;25685;63868;24471;102551184;29455;299626;58868;25427;65210;306575;64515;25599;362485;114494;25612;25649;502970;81633;50559;170465;114628 zwint;vnn1;trim59;top2a;sytl2;sult1e1;srebf1;sptan1;slpi;serpina6;rt1-ce5;prkar2b;prc1;pparg;pir;pdlim1;orm1;nrep;nr1i3;nr1d2;mki67;mapkapk3;krt8;kif18b;igfbp3;igfbp1;hspd1;hspb1;loc102551184;gdf15;gadd45b;fzd1;cyp51;cyp2j4;ckap2;cdc20;cd74;ccne2;ccna2;asns;apoa2;angptl3;acta2;acot1;acaa2;abcg5 ZWINT_10214;VNN1_10157;TRIM59_10085;TOP2A_10059;SYTL2_32351;SULT1E1_32446;SREBF1_32750;SPTAN1_9932;SLPI_9890;SERPINA6_32325;RT1-CE5_32445;PRKAR2B_33052;PRC1_9556;PPARG_32510;PIR_9487;PDLIM1_9452;ORM1_9400;NREP_9364;NR1I3_32602;NR1D2_9358;MKI67_9232;MAPKAPK3_9194;KRT8_8978;KIF18B_32882;IGFBP3_8881;IGFBP1_32306;HSPD1_8849;HSPB1_8847;HIST1H4A_32934;GDF15_33113;GADD45B_8679;FZD1_8671;CYP51_8429;CYP2J4_32580;CKAP2_8324;CDC20_8255;CD74_8252;CCNE2_8227;CCNA2_8221;ASNS_8091;APOA2_33095;ANGPTL3_8045;ACTA2_33040;ACOT1_7968;ACAA2_7955;ABCG5_7947 25664(0.0441) 57.42392782608696 57.10035 3.54778 25.544415315071536 57.13395703649316 23.68547107533239 36.85656391304347 38.94745 1.51564 14.650579418008409 37.03931970235616 14.152925833819607 119.14846195652171 101.94749999999999 8.55785 92.66709873412536 114.97517517570773 85.36234974622609 59.0663;20.7328;56.1278;54.9577;67.0093;59.2729;41.2009;47.5519;53.7429;68.3847;54.8206;108.746;80.3005;60.1903;52.1607;67.1147;24.2519;69.4104;22.095;99.0234;49.7822;104.193;68.9539;65.9823;50.946;98.8371;34.4455;41.6322;58.3303;21.3654;52.5718;25.231;75.1522;16.3155;64.2131;101.569;94.9138;77.8893;52.8265;28.1893;3.54778;58.0729;90.3558;28.5134;78.3988;33.1119 40.5797;16.8296;33.6269;18.8326;44.4373;45.3114;31.4864;34.4152;37.8192;36.9679;26.5902;59.3814;50.2731;43.9036;40.9644;47.2419;19.7133;43.1468;12.9529;42.5557;35.6665;59.1667;45.3374;43.9552;36.3081;57.328;26.6907;30.9494;40.2068;17.8875;37.1918;13.6792;48.098;8.2378;43.1133;51.5499;58.8146;49.2672;37.3288;23.1774;1.51564;40.0757;70.2676;24.741;43.6084;24.2098 108.188;26.7838;121.883;218.525;135.846;91.5578;60.0774;76.6397;92.543;89.5095;147.824;147.467;198.961;101.057;74.9097;123.914;31.358;157.944;55.8619;102.838;82.1147;434.985;143.578;131.93;85.0816;357.409;48.4857;63.3196;105.902;26.3528;89.36;131.659;171.379;36.8422;125.437;453.17;118.773;185.461;90.0448;35.9474;8.55785;105.112;103.57;33.4642;98.7727;50.4329 26 20 26 257644;29142;360268;78968;64159;299270;24679;25664;363465;54133;24614;65035;259241;25626;25685;63868;24471;29455;299626;58868;65210;25599;25612;25649;502970;50559 ZWINT_10214;VNN1_10157;SULT1E1_32446;SREBF1_32750;SPTAN1_9932;SERPINA6_32325;PRKAR2B_33052;PPARG_32510;PIR_9487;PDLIM1_9452;ORM1_9400;NR1I3_32602;NR1D2_9358;KRT8_8978;IGFBP1_32306;HSPD1_8849;HSPB1_8847;GDF15_33113;GADD45B_8679;FZD1_8671;CYP2J4_32580;CD74_8252;ASNS_8091;APOA2_33095;ANGPTL3_8045;ACOT1_7968 50.09158000000001 49.856300000000005 28.250311698225204 32.99729 35.69155 15.664378401906662 88.03932884615385 82.99985000000001 67.55989471801176 59.0663;20.7328;59.2729;41.2009;47.5519;68.3847;108.746;60.1903;52.1607;67.1147;24.2519;22.095;99.0234;68.9539;98.8371;34.4455;41.6322;21.3654;52.5718;25.231;16.3155;94.9138;28.1893;3.54778;58.0729;28.5134 40.5797;16.8296;45.3114;31.4864;34.4152;36.9679;59.3814;43.9036;40.9644;47.2419;19.7133;12.9529;42.5557;45.3374;57.328;26.6907;30.9494;17.8875;37.1918;13.6792;8.2378;58.8146;23.1774;1.51564;40.0757;24.741 108.188;26.7838;91.5578;60.0774;76.6397;89.5095;147.467;101.057;74.9097;123.914;31.358;55.8619;102.838;143.578;357.409;48.4857;63.3196;26.3528;89.36;131.659;36.8422;118.773;35.9474;8.55785;105.112;33.4642 20 365813;360243;361604;84386;309607;308761;338475;291234;315994;303575;24484;102551184;25427;306575;64515;362485;114494;81633;170465;114628 TRIM59_10085;TOP2A_10059;SYTL2_32351;SLPI_9890;RT1-CE5_32445;PRC1_9556;NREP_9364;MKI67_9232;MAPKAPK3_9194;KIF18B_32882;IGFBP3_8881;HIST1H4A_32934;CYP51_8429;CKAP2_8324;CDC20_8255;CCNE2_8227;CCNA2_8221;ACTA2_33040;ACAA2_7955;ABCG5_7947 66.95598 65.0977 18.058708834611167 41.873619999999995 43.13005 11.773737055238465 159.590335 128.6835 106.23756520502471 56.1278;54.9577;67.0093;53.7429;54.8206;80.3005;69.4104;49.7822;104.193;65.9823;50.946;58.3303;75.1522;64.2131;101.569;77.8893;52.8265;90.3558;78.3988;33.1119 33.6269;18.8326;44.4373;37.8192;26.5902;50.2731;43.1468;35.6665;59.1667;43.9552;36.3081;40.2068;48.098;43.1133;51.5499;49.2672;37.3288;70.2676;43.6084;24.2098 121.883;218.525;135.846;92.543;147.824;198.961;157.944;82.1147;434.985;131.93;85.0816;105.902;171.379;125.437;453.17;185.461;90.0448;103.57;98.7727;50.4329 0 Exp 2,16(0.35);Exp 4,1(0.03);Hill,1(0.03);Linear,20(0.44);Poly 2,6(0.14);Power,2(0.05) 2.0815108722526863 142.55633568763733 1.5062377452850342 50.888092041015625 7.243169852572123 1.7333461046218872 50.04194344282792 64.80591220934599 32.622748140183575 41.0903796859034 92.36894607174722 145.92797784129627 CONFLICT 0.5652173913043478 0.43478260869565216 0.0 GO:1990705 5 cholangiocyte proliferation 1 1 1 1 1 1 1 1 95 0 2451 1.0 0.037691 0.037691 100.0 291234 mki67 MKI67_9232 49.7822 49.7822 49.7822 49.7822 35.6665 35.6665 35.6665 35.6665 82.1147 82.1147 82.1147 82.1147 0.0 49.7822 0.0 49.7822 49.7822 35.6665 82.1147 0 1 0 1 291234 MKI67_9232 49.7822 49.7822 35.6665 35.6665 82.1147 82.1147 49.7822 35.6665 82.1147 0 Linear,1(1) 2.285626173019409 2.285626173019409 2.285626173019409 2.285626173019409 0.0 2.285626173019409 49.7822 49.7822 35.6665 35.6665 82.1147 82.1147 DOWN 0.0 1.0 0.0 GO:0009410 4 response to xenobiotic stimulus 123 132 5 5 5 5 5 5 91 127 2324 0.62075 0.56296 1.0 3.79 24950;24679;25664;63868;114494 srd5a1;prkar2b;pparg;hspd1;ccna2 SRD5A1_32503;PRKAR2B_33052;PPARG_32510;HSPD1_8849;CCNA2_8221 25664(0.0441) 57.083400000000005 52.8265 29.2087 31.56846401268201 55.03398828401896 27.136313785565008 38.04706 37.3288 22.9308 14.555387750520422 37.91153707538529 13.03581417063937 85.40794000000001 90.0448 39.9852 43.42867023451213 84.49308310700489 38.996629780544176 29.2087;108.746;60.1903;34.4455;52.8265 22.9308;59.3814;43.9036;26.6907;37.3288 39.9852;147.467;101.057;48.4857;90.0448 3 2 3 24679;25664;63868 PRKAR2B_33052;PPARG_32510;HSPD1_8849 67.79393333333333 60.1903 37.72933215633871 43.32523333333334 43.9036 16.353022583710104 99.00323333333334 101.057 49.52259994753239 108.746;60.1903;34.4455 59.3814;43.9036;26.6907 147.467;101.057;48.4857 2 24950;114494 SRD5A1_32503;CCNA2_8221 41.0176 41.0176 16.700306536707636 30.129800000000003 30.129800000000003 10.180923435523901 65.015 65.015 35.39748262348606 29.2087;52.8265 22.9308;37.3288 39.9852;90.0448 0 Exp 2,2(0.4);Linear,2(0.4);Power,1(0.2) 1.793546629877782 9.077430129051208 1.5239794254302979 2.3255980014801025 0.3267427211664582 1.6557694673538208 29.412421260775787 84.75437873922421 25.28870011197969 50.80541988802031 47.34103214381799 123.47484785618204 UP 0.6 0.4 0.0 GO:0098656 6 anion transmembrane transport 47 47 3 3 3 3 3 3 93 44 2407 0.90144 0.25986 0.25986 6.38 117267;503568;140668 slc26a2;slc13a4;abcc3 SLC26A2_33072;SLC13A4_9836;ABCC3_7941 51.715466666666664 54.7452 34.7775 15.64469484085045 50.50942555586057 13.840510307784163 35.898533333333326 38.3503 26.6562 8.292878899594143 35.499768844359046 7.536803451521786 93.61726666666668 95.3373 49.7705 43.01255120965659 88.5069104584134 36.67718841289692 1.5 60.18445 54.7452;65.6237;34.7775 38.3503;42.6891;26.6562 95.3373;135.744;49.7705 1 2 1 140668 ABCC3_7941 34.7775 34.7775 26.6562 26.6562 49.7705 49.7705 34.7775 26.6562 49.7705 2 117267;503568 SLC26A2_33072;SLC13A4_9836 60.18445 60.18445 7.692261119137861 40.5197 40.5197 3.067994902212159 115.54065 115.54065 28.571851575370424 54.7452;65.6237 38.3503;42.6891 95.3373;135.744 0 Exp 2,1(0.34);Linear,2(0.67) 1.6719450933861237 5.0569236278533936 1.5239086151123047 1.998015284538269 0.27058071876133155 1.5349997282028198 34.01182786226771 69.41910547106562 26.514257437859577 45.28280922880709 44.94398294858815 142.2905503847452 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0009069 8 serine family amino acid metabolic process 11 13 2 2 2 2 2 2 94 11 2440 0.98873 0.083726 0.083726 15.38 293820;114027 psat1;dao PSAT1_9583;DAO_8437 16.2326 16.2326 6.1336 14.28214276640589 19.986241405442648 13.258957515532401 11.677485 11.677485 2.43617 13.069193007161918 15.112338215638994 12.132904542296494 25.74905 25.74905 16.2027 13.500577641160394 29.297279986221152 12.533384402257928 0.0 6.1336 0.5 16.2326 26.3316;6.1336 20.9188;2.43617 35.2954;16.2027 2 0 2 293820;114027 PSAT1_9583;DAO_8437 16.2326 16.2326 14.28214276640589 11.677485 11.677485 13.069193007161918 25.74905 25.74905 13.500577641160394 26.3316;6.1336 20.9188;2.43617 35.2954;16.2027 0 0 Hill,1(0.5);Linear,1(0.5) 2.325803622221447 4.685157775878906 2.0627336502075195 2.6224241256713867 0.39576093056602346 2.342578887939453 -3.561439999999994 36.02664 -6.435492399999998 29.7904624 7.038204 44.459896 UP 1.0 0.0 0.0 GO:1903706 5 regulation of hemopoiesis 119 128 4 4 3 4 3 3 93 125 2326 0.27825 0.87141 0.62988 2.34 29142;102551184;25599 vnn1;loc102551184;cd74 VNN1_10157;HIST1H4A_32934;CD74_8252 57.9923 58.3303 20.7328 37.09165503519625 75.9935716689327 36.39056778093206 38.617 40.2068 16.8296 21.03760096303759 48.35425562542488 20.431746145549315 83.8196 105.902 26.7838 49.811921479501265 99.15442165193745 44.14782425790275 20.7328;58.3303;94.9138 16.8296;40.2068;58.8146 26.7838;105.902;118.773 2 1 2 29142;25599 VNN1_10157;CD74_8252 57.823299999999996 57.823299999999996 52.45388813519929 37.8221 37.8221 29.687878208117194 72.7784 72.7784 65.04618711592555 20.7328;94.9138 16.8296;58.8146 26.7838;118.773 1 102551184 HIST1H4A_32934 58.3303 58.3303 40.2068 40.2068 105.902 105.902 58.3303 40.2068 105.902 0 Linear,2(0.67);Poly 2,1(0.34) 2.329846765143394 7.921655535697937 1.6554155349731445 4.608505725860596 1.7042984484378392 1.6577342748641968 16.019141042251775 99.96545895774823 14.810713424937184 62.42328657506281 27.452104500916583 140.1870954990834 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0051247 7 positive regulation of protein metabolic process 428 454 17 17 12 16 12 12 84 442 2009 0.10154 0.94178 0.21976 2.64 78968;25664;24484;63868;24471;29455;299626;58868;64515;25599;25649;81633 srebf1;pparg;igfbp3;hspd1;hspb1;gdf15;gadd45b;fzd1;cdc20;cd74;apoa2;acta2 SREBF1_32750;PPARG_32510;IGFBP3_8881;HSPD1_8849;HSPB1_8847;GDF15_33113;GADD45B_8679;FZD1_8671;CDC20_8255;CD74_8252;APOA2_33095;ACTA2_33040 25664(0.0441) 51.497456666666665 46.2891 3.54778 30.7042840981454 54.20581467202032 29.287074974539966 35.02037 33.89725 1.51564 19.393147676450518 36.94900362502414 18.50864622918665 107.45532916666667 87.2208 8.55785 114.86948310053788 105.81330721431135 104.0339878852304 41.2009;60.1903;50.946;34.4455;41.6322;21.3654;52.5718;25.231;101.569;94.9138;3.54778;90.3558 31.4864;43.9036;36.3081;26.6907;30.9494;17.8875;37.1918;13.6792;51.5499;58.8146;1.51564;70.2676 60.0774;101.057;85.0816;48.4857;63.3196;26.3528;89.36;131.659;453.17;118.773;8.55785;103.57 9 3 9 78968;25664;63868;24471;29455;299626;58868;25599;25649 SREBF1_32750;PPARG_32510;HSPD1_8849;HSPB1_8847;GDF15_33113;GADD45B_8679;FZD1_8671;CD74_8252;APOA2_33095 41.677631111111104 41.2009 26.184414528144636 29.124315555555555 30.9494 16.981291137062517 71.96026111111111 63.3196 41.49031174602526 41.2009;60.1903;34.4455;41.6322;21.3654;52.5718;25.231;94.9138;3.54778 31.4864;43.9036;26.6907;30.9494;17.8875;37.1918;13.6792;58.8146;1.51564 60.0774;101.057;48.4857;63.3196;26.3528;89.36;131.659;118.773;8.55785 3 24484;64515;81633 IGFBP3_8881;CDC20_8255;ACTA2_33040 80.95693333333334 90.3558 26.588081036685068 52.70853333333334 51.5499 17.009371930301604 213.94053333333332 103.57 207.38492839368377 50.946;101.569;90.3558 36.3081;51.5499;70.2676 85.0816;453.17;103.57 0 Exp 2,5(0.42);Hill,1(0.09);Linear,3(0.25);Poly 2,3(0.25) 1.8150104832585678 23.271387100219727 1.5124053955078125 5.015069484710693 0.9771049998453774 1.6567518711090088 34.12487251111445 68.87004082221888 24.047663749195785 45.993076250804215 42.46180071669335 172.44885761664 UP 0.75 0.25 0.0 GO:0031329 6 regulation of cellular catabolic process 171 183 7 6 4 7 3 3 93 180 2271 0.075558 0.97418 0.15513 1.64 78968;24484;64515 srebf1;igfbp3;cdc20 SREBF1_32750;IGFBP3_8881;CDC20_8255 64.57196666666665 50.946 41.2009 32.4087503631864 59.755418114622394 31.1793153871016 39.78146666666667 36.3081 31.4864 10.473023205518686 38.06288263524371 10.22268718431658 199.44299999999998 85.0816 60.0774 220.08940320051767 170.941000085699 208.22789592339163 41.2009;50.946;101.569 31.4864;36.3081;51.5499 60.0774;85.0816;453.17 1 2 1 78968 SREBF1_32750 41.2009 41.2009 31.4864 31.4864 60.0774 60.0774 41.2009 31.4864 60.0774 2 24484;64515 IGFBP3_8881;CDC20_8255 76.2575 76.2575 35.79586658400661 43.929 43.929 10.77758013748912 269.1258 269.1258 260.27780371610635 50.946;101.569 36.3081;51.5499 85.0816;453.17 0 Exp 2,2(0.67);Linear,1(0.34) 1.7194509762239671 5.179901361465454 1.5293418169021606 1.912555456161499 0.19185967825842443 1.7380040884017944 27.898013203947983 101.24592012938535 27.93012524347324 51.63280808986009 -49.611605319861724 448.4976053198617 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0043603 5 cellular amide metabolic process 114 134 12 12 12 12 12 12 84 122 2329 0.99876 0.0038022 0.0038022 8.96 29142;298490;680308;362094;364975;25612;24763;681337;314304;192272;50559;170465 vnn1;ppcs;mthfd2;mrps2;gcdh;asns;acsm3;acot4;acot3;acot2;acot1;acaa2 VNN1_10157;PPCS_9540;MTHFD2_9261;MRPS2_9250;GCDH_8693;ASNS_8091;ACSM3_7976;ACOT4_7971;ACOT3_7970;ACOT2_7969;ACOT1_7968;ACAA2_7955 34.718425 28.35135 12.3157 22.407860927569995 39.37598745629898 25.948178009087503 25.286021666666667 23.9324 6.70485 15.403981575521215 27.387090691581278 16.769657339198158 50.137708333333336 34.705799999999996 16.9658 31.653229192998143 58.3073494655415 38.11883882464068 5.5 28.35135 20.7328;15.1091;57.4184;63.3158;15.9021;28.1893;52.2057;12.3157;30.8838;13.6362;28.5134;78.3988 16.8296;7.94061;46.387;45.3429;10.4227;23.1774;42.2655;6.70485;24.6874;11.3249;24.741;43.6084 26.7838;30.6311;79.7903;111.245;31.2818;35.9474;71.1126;24.3993;41.2585;16.9658;33.4642;98.7727 11 1 11 29142;298490;680308;362094;364975;25612;24763;681337;314304;192272;50559 VNN1_10157;PPCS_9540;MTHFD2_9261;MRPS2_9250;GCDH_8693;ASNS_8091;ACSM3_7976;ACOT4_7971;ACOT3_7970;ACOT2_7969;ACOT1_7968 30.74748181818182 28.1893 18.552107959518676 23.620350909090906 23.1774 14.979587893463869 45.71634545454546 33.4642 29.0530561914014 20.7328;15.1091;57.4184;63.3158;15.9021;28.1893;52.2057;12.3157;30.8838;13.6362;28.5134 16.8296;7.94061;46.387;45.3429;10.4227;23.1774;42.2655;6.70485;24.6874;11.3249;24.741 26.7838;30.6311;79.7903;111.245;31.2818;35.9474;71.1126;24.3993;41.2585;16.9658;33.4642 1 170465 ACAA2_7955 78.3988 78.3988 43.6084 43.6084 98.7727 98.7727 78.3988 43.6084 98.7727 0 Exp 2,6(0.5);Hill,2(0.17);Linear,2(0.17);Poly 2,2(0.17) 3.081048709841855 79.33248603343964 1.5277283191680908 50.888092041015625 13.984973865458556 2.4932953119277954 22.039984152273686 47.3968658477263 16.57039861563184 34.001644717701495 32.228207945940895 68.04720872072576 UP 0.9166666666666666 0.08333333333333333 0.0 GO:0019254 7 carnitine metabolic process, CoA-linked 3 3 1 1 1 1 1 1 95 2 2449 0.99588 0.10891 0.10891 33.33 311849 crat CRAT_8375 8.98517 8.98517 8.98517 8.98517 1.97988 1.97988 1.97988 1.97988 31.3726 31.3726 31.3726 31.372599999999995 0.0 8.98517 0.0 8.98517 8.98517 1.97988 31.3726 1 0 1 311849 CRAT_8375 8.98517 8.98517 1.97988 1.97988 31.3726 31.3726 8.98517 1.97988 31.3726 0 0 Hill,1(1) 1.7233848571777344 1.7233848571777344 1.7233848571777344 1.7233848571777344 0.0 1.7233848571777344 8.98517 8.98517 1.97988 1.97988 31.3726 31.3726 UP 1.0 0.0 0.0 GO:0007565 4 female pregnancy 40 42 5 5 4 5 4 4 92 38 2413 0.9807 0.071158 0.071158 9.52 360268;24484;24471;65210 sult1e1;igfbp3;hspb1;cyp2j4 SULT1E1_32446;IGFBP3_8881;HSPB1_8847;CYP2J4_32580 42.04165 46.2891 16.3155 18.602919740460106 40.78070001044641 20.46858705191779 30.201675 33.628750000000004 8.2378 15.79623492637301 29.219347942057247 17.4972733178551 69.2003 74.2006 36.8422 24.72315219950723 67.54104818580682 26.698516908577233 1.5 46.2891 59.2729;50.946;41.6322;16.3155 45.3114;36.3081;30.9494;8.2378 91.5578;85.0816;63.3196;36.8422 3 1 3 360268;24471;65210 SULT1E1_32446;HSPB1_8847;CYP2J4_32580 39.07353333333333 41.6322 21.592698650778544 28.166200000000003 30.9494 18.692849058396632 63.906533333333336 63.3196 27.362521610650788 59.2729;41.6322;16.3155 45.3114;30.9494;8.2378 91.5578;63.3196;36.8422 1 24484 IGFBP3_8881 50.946 50.946 36.3081 36.3081 85.0816 85.0816 50.946 36.3081 85.0816 0 Exp 2,1(0.25);Exp 4,1(0.25);Linear,2(0.5) 2.069619486088621 8.470913648605347 1.7380040884017944 2.9455835819244385 0.5580706680021582 1.8936629891395569 23.8107886543491 60.2725113456509 14.721364772154448 45.68198522784556 44.971610844482896 93.4289891555171 UP 0.75 0.25 0.0 GO:0050728 7 negative regulation of inflammatory response 47 48 4 4 3 4 3 3 93 45 2406 0.89544 0.27021 0.42561 6.25 84386;25664;259241 slpi;pparg;nr1d2 SLPI_9890;PPARG_32510;NR1D2_9358 25664(0.0441) 70.98553333333332 60.1903 53.7429 24.494565052340388 63.93186265613173 19.613755627188123 41.42616666666667 42.5557 37.8192 3.195600882984915 41.06911160579107 3.4947627059780344 98.81266666666666 101.057 92.543 5.502229578392534 97.70502483913701 5.528306562612903 1.5 79.60685 53.7429;60.1903;99.0234 37.8192;43.9036;42.5557 92.543;101.057;102.838 2 1 2 25664;259241 PPARG_32510;NR1D2_9358 79.60685 79.60685 27.45914834449535 43.22965 43.22965 0.9531092303614551 101.94749999999999 101.94749999999999 1.2593571772946877 60.1903;99.0234 43.9036;42.5557 101.057;102.838 1 84386 SLPI_9890 53.7429 53.7429 37.8192 37.8192 92.543 92.543 53.7429 37.8192 92.543 0 Exp 2,1(0.34);Linear,1(0.34);Power,1(0.34) 1.9241138829617652 5.965067028999329 1.5239794254302979 2.7270524501800537 0.6467495556251959 1.714035153388977 43.267323629096396 98.70374303757028 37.81000384783945 45.04232948549389 92.58630775934014 105.0390255739932 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0008610 5 lipid biosynthetic process 109 122 11 10 7 11 6 6 90 116 2335 0.82661 0.31064 0.46154 4.92 78968;24950;25427;25599;25649;24763 srebf1;srd5a1;cyp51;cd74;apoa2;acsm3 SREBF1_32750;SRD5A1_32503;CYP51_8429;CD74_8252;APOA2_33095;ACSM3_7976 49.37151333333333 46.7033 3.54778 32.61867193574052 48.981464085357835 35.880553282574645 34.185156666666664 36.87595 1.51564 20.33081300721806 33.277300644123436 22.01575051373025 78.31417499999999 65.595 8.55785 58.339482376172555 69.65225231615233 50.03805755501204 41.2009;29.2087;75.1522;94.9138;3.54778;52.2057 31.4864;22.9308;48.098;58.8146;1.51564;42.2655 60.0774;39.9852;171.379;118.773;8.55785;71.1126 4 2 4 78968;25599;25649;24763 SREBF1_32750;CD74_8252;APOA2_33095;ACSM3_7976 47.967045 46.7033 37.59794241950083 33.520534999999995 36.87595 24.11579804633401 64.6302125 65.595 45.23383955978781 41.2009;94.9138;3.54778;52.2057 31.4864;58.8146;1.51564;42.2655 60.0774;118.773;8.55785;71.1126 2 24950;25427 SRD5A1_32503;CYP51_8429 52.18044999999999 52.18044999999999 32.48696040144416 35.5144 35.5144 17.795897783478058 105.68209999999999 105.68209999999999 92.909446985869 29.2087;75.1522 22.9308;48.098 39.9852;171.379 0 Exp 2,2(0.34);Hill,1(0.17);Linear,2(0.34);Poly 2,1(0.17) 1.8904673575914102 11.497881531715393 1.633623480796814 2.6164326667785645 0.3672339641399933 1.8194039463996887 23.271139905596723 75.47188676106994 17.91711814494968 50.45319518838366 31.632866864626536 124.99548313537348 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0032269 7 negative regulation of cellular protein metabolic process 274 292 9 9 6 9 6 6 90 286 2165 0.062873 0.97237 0.1389 2.05 84386;299270;24679;24484;24471;299626 slpi;serpina6;prkar2b;igfbp3;hspb1;gadd45b SLPI_9890;SERPINA6_32325;PRKAR2B_33052;IGFBP3_8881;HSPB1_8847;GADD45B_8679 62.6706 53.15735 41.6322 24.155179702995365 59.164810138531315 18.5504670997239 39.76963333333333 37.07985 30.9494 9.92672398541769 38.105908194189034 7.352799589341405 94.54678333333334 89.43475000000001 63.3196 28.005599793213996 90.65514063748928 21.190364247868594 53.7429;68.3847;108.746;50.946;41.6322;52.5718 37.8192;36.9679;59.3814;36.3081;30.9494;37.1918 92.543;89.5095;147.467;85.0816;63.3196;89.36 4 2 4 299270;24679;24471;299626 SERPINA6_32325;PRKAR2B_33052;HSPB1_8847;GADD45B_8679 67.833675 60.47825 29.402744124471877 41.122625 37.07985 12.511201599733214 97.41402500000001 89.43475000000001 35.56720847732031 68.3847;108.746;41.6322;52.5718 36.9679;59.3814;30.9494;37.1918 89.5095;147.467;63.3196;89.36 2 84386;24484 SLPI_9890;IGFBP3_8881 52.344449999999995 52.344449999999995 1.9777069563008396 37.06365 37.06365 1.0685090570510773 88.8123 88.8123 5.27600653714571 53.7429;50.946 37.8192;36.3081 92.543;85.0816 0 Linear,4(0.67);Poly 2,1(0.17);Power,1(0.17) 1.7198729671088113 10.341582775115967 1.5528020858764648 1.8690931797027588 0.12360997050169377 1.7260196208953857 43.34243079359328 81.99876920640672 31.826599863304686 47.71266680336199 72.13763638490369 116.95593028176299 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0032788 8 saturated monocarboxylic acid metabolic process 2 2 2 2 2 2 2 2 94 0 2451 1.0 0.0014064 0.0014064 100.0 681337;314304 acot4;acot3 ACOT4_7971;ACOT3_7970 21.59975 21.59975 12.3157 13.129629423749932 18.89799871254162 12.561379254143791 15.696125 15.696125 6.70485 12.71558304802615 13.079574162042174 12.165252799511173 32.8289 32.8289 24.3993 11.921254645380237 30.37580219755827 11.405302918524816 0.0 12.3157 0.0 12.3157 12.3157;30.8838 6.70485;24.6874 24.3993;41.2585 2 0 2 681337;314304 ACOT4_7971;ACOT3_7970 21.59975 21.59975 13.129629423749932 15.696125 15.696125 12.71558304802615 32.8289 32.8289 11.921254645380237 12.3157;30.8838 6.70485;24.6874 24.3993;41.2585 0 0 Exp 2,1(0.5);Hill,1(0.5) 2.6008651257504787 5.224186897277832 2.3701579570770264 2.8540289402008057 0.34214845338622585 2.612093448638916 3.4030120000000004 39.796488 -1.926774 33.319024 16.306884 49.350916 UP 1.0 0.0 0.0 GO:0032789 8 unsaturated monocarboxylic acid metabolic process 2 2 2 2 2 2 2 2 94 0 2451 1.0 0.0014064 0.0014064 100.0 681337;314304 acot4;acot3 ACOT4_7971;ACOT3_7970 21.59975 21.59975 12.3157 13.129629423749932 18.89799871254162 12.561379254143791 15.696125 15.696125 6.70485 12.71558304802615 13.079574162042174 12.165252799511173 32.8289 32.8289 24.3993 11.921254645380237 30.37580219755827 11.405302918524816 0.0 12.3157 0.0 12.3157 12.3157;30.8838 6.70485;24.6874 24.3993;41.2585 2 0 2 681337;314304 ACOT4_7971;ACOT3_7970 21.59975 21.59975 13.129629423749932 15.696125 15.696125 12.71558304802615 32.8289 32.8289 11.921254645380237 12.3157;30.8838 6.70485;24.6874 24.3993;41.2585 0 0 Exp 2,1(0.5);Hill,1(0.5) 2.6008651257504787 5.224186897277832 2.3701579570770264 2.8540289402008057 0.34214845338622585 2.612093448638916 3.4030120000000004 39.796488 -1.926774 33.319024 16.306884 49.350916 UP 1.0 0.0 0.0 GO:0071378 7 cellular response to growth hormone stimulus 5 5 2 2 2 2 2 2 94 3 2448 0.99951 0.013053 0.013053 40.0 286954;24614 ugt2b1;orm1 UGT2B10_33303,UGT2B1_33224;ORM1_9400 18.398025 18.398025 12.54415 8.278629417436797 19.44591364801689 8.144910299933617 13.530772500000001 13.530772500000001 7.348245 8.743414240244622 14.63749247323179 8.602187766970227 28.426924999999997 28.426924999999997 25.495849999999997 4.145166017332751 28.95160996833057 4.078211946339457 0.0 12.54415 0.0 12.54415 12.54415;24.2519 7.348245;19.7133 25.495849999999997;31.358 3 0 2 286954;24614 UGT2B10_33303,UGT2B1_33224;ORM1_9400 18.398025 18.398025 8.278629417436797 13.530772500000001 13.530772500000001 8.743414240244622 28.426924999999997 28.426924999999997 4.145166017332751 12.54415;24.2519 7.348245;19.7133 25.495849999999997;31.358 0 0 Exp 2,1(0.34);Exp 4,1(0.34);Poly 2,1(0.34) 2.164515823680225 6.950080513954163 1.635288953781128 3.5849626064300537 1.099369973572612 1.729828953742981 6.924430000000003 29.87162 1.4130186000000027 25.6485264 22.682017999999996 34.171831999999995 UP 1.0 0.0 0.0 GO:0048523 5 negative regulation of cellular process 938 999 40 39 30 39 29 29 67 970 1481 0.039587 0.97594 0.070239 2.9 257644;29142;365813;360243;361604;78968;64159;84386;299270;309607;24679;25664;65035;259241;24484;63868;24471;102551184;29455;299626;58868;25427;65210;306575;25599;25612;25649;50559;170465 zwint;vnn1;trim59;top2a;sytl2;srebf1;sptan1;slpi;serpina6;rt1-ce5;prkar2b;pparg;nr1i3;nr1d2;igfbp3;hspd1;hspb1;loc102551184;gdf15;gadd45b;fzd1;cyp51;cyp2j4;ckap2;cd74;asns;apoa2;acot1;acaa2 ZWINT_10214;VNN1_10157;TRIM59_10085;TOP2A_10059;SYTL2_32351;SREBF1_32750;SPTAN1_9932;SLPI_9890;SERPINA6_32325;RT1-CE5_32445;PRKAR2B_33052;PPARG_32510;NR1I3_32602;NR1D2_9358;IGFBP3_8881;HSPD1_8849;HSPB1_8847;HIST1H4A_32934;GDF15_33113;GADD45B_8679;FZD1_8671;CYP51_8429;CYP2J4_32580;CKAP2_8324;CD74_8252;ASNS_8091;APOA2_33095;ACOT1_7968;ACAA2_7955 25664(0.0441) 51.29019586206897 53.7429 3.54778 25.458683980622606 52.23814150888653 23.882820255006354 32.22752551724138 34.4152 1.51564 14.180461449146847 32.90607961091148 14.147172873110598 91.87508103448276 92.543 8.55785 48.513703168965584 92.83853851399746 43.165703452721004 59.0663;20.7328;56.1278;54.9577;67.0093;41.2009;47.5519;53.7429;68.3847;54.8206;108.746;60.1903;22.095;99.0234;50.946;34.4455;41.6322;58.3303;21.3654;52.5718;25.231;75.1522;16.3155;64.2131;94.9138;28.1893;3.54778;28.5134;78.3988 40.5797;16.8296;33.6269;18.8326;44.4373;31.4864;34.4152;37.8192;36.9679;26.5902;59.3814;43.9036;12.9529;42.5557;36.3081;26.6907;30.9494;40.2068;17.8875;37.1918;13.6792;48.098;8.2378;43.1133;58.8146;23.1774;1.51564;24.741;43.6084 108.188;26.7838;121.883;218.525;135.846;60.0774;76.6397;92.543;89.5095;147.824;147.467;101.057;55.8619;102.838;85.0816;48.4857;63.3196;105.902;26.3528;89.36;131.659;171.379;36.8422;125.437;118.773;35.9474;8.55785;33.4642;98.7727 19 10 19 257644;29142;78968;64159;299270;24679;25664;65035;259241;63868;24471;29455;299626;58868;65210;25599;25612;25649;50559 ZWINT_10214;VNN1_10157;SREBF1_32750;SPTAN1_9932;SERPINA6_32325;PRKAR2B_33052;PPARG_32510;NR1I3_32602;NR1D2_9358;HSPD1_8849;HSPB1_8847;GDF15_33113;GADD45B_8679;FZD1_8671;CYP2J4_32580;CD74_8252;ASNS_8091;APOA2_33095;ACOT1_7968 45.985104210526316 41.2009 29.61787671045428 29.576707368421054 30.9494 15.8520246506428 71.64126578947368 63.3196 39.70647840722404 59.0663;20.7328;41.2009;47.5519;68.3847;108.746;60.1903;22.095;99.0234;34.4455;41.6322;21.3654;52.5718;25.231;16.3155;94.9138;28.1893;3.54778;28.5134 40.5797;16.8296;31.4864;34.4152;36.9679;59.3814;43.9036;12.9529;42.5557;26.6907;30.9494;17.8875;37.1918;13.6792;8.2378;58.8146;23.1774;1.51564;24.741 108.188;26.7838;60.0774;76.6397;89.5095;147.467;101.057;55.8619;102.838;48.4857;63.3196;26.3528;89.36;131.659;36.8422;118.773;35.9474;8.55785;33.4642 10 365813;360243;361604;84386;309607;24484;102551184;25427;306575;170465 TRIM59_10085;TOP2A_10059;SYTL2_32351;SLPI_9890;RT1-CE5_32445;IGFBP3_8881;HIST1H4A_32934;CYP51_8429;CKAP2_8324;ACAA2_7955 61.36986999999999 57.22905 9.471472296680096 37.26408 39.013000000000005 8.944610936051575 130.31932999999998 123.66 40.77445043755412 56.1278;54.9577;67.0093;53.7429;54.8206;50.946;58.3303;75.1522;64.2131;78.3988 33.6269;18.8326;44.4373;37.8192;26.5902;36.3081;40.2068;48.098;43.1133;43.6084 121.883;218.525;135.846;92.543;147.824;85.0816;105.902;171.379;125.437;98.7727 0 Exp 2,9(0.32);Exp 4,1(0.04);Hill,1(0.04);Linear,11(0.38);Poly 2,5(0.18);Power,2(0.07) 2.161173684947788 108.2556060552597 1.5062377452850342 50.888092041015625 9.110382013445783 1.72868812084198 42.024180356673114 60.5562113674648 27.066364172001673 37.38868686248108 74.21789474276568 109.53226732619981 UP 0.6551724137931034 0.3448275862068966 0.0 GO:0015909 8 long-chain fatty acid transport 19 21 3 3 2 3 2 2 94 19 2432 0.95782 0.18628 0.18628 9.52 25664;25413 pparg;cpt2 PPARG_32510;CPT2_8374 25664(0.0441) 45.703900000000004 45.703900000000004 31.2175 20.486863349961588 51.00974260667682 19.0632536149091 34.3696 34.3696 24.8356 13.483112103665087 37.86155820991114 12.546185385226373 71.54035 71.54035 42.0237 41.7428467458198 82.35122773196701 38.84218196463635 0.5 45.703900000000004 60.1903;31.2175 43.9036;24.8356 101.057;42.0237 2 0 2 25664;25413 PPARG_32510;CPT2_8374 45.703900000000004 45.703900000000004 20.486863349961588 34.3696 34.3696 13.483112103665087 71.54035 71.54035 41.7428467458198 60.1903;31.2175 43.9036;24.8356 101.057;42.0237 0 0 Exp 2,2(1) 1.69126885704222 3.4009013175964355 1.5239794254302979 1.8769218921661377 0.24956801159761982 1.7004506587982178 17.31055600000001 74.097244 15.682960000000001 53.056239999999995 13.687716000000002 129.392984 UP 1.0 0.0 0.0 GO:0006807 3 nitrogen compound metabolic process 1028 1128 44 43 38 43 37 37 59 1091 1360 0.14661 0.89668 0.29492 3.28 29142;365813;360243;360268;64305;78968;24950;293820;298490;25664;313245;680308;362094;291234;316273;315994;293502;24484;63868;364975;171142;114027;25086;311849;297594;64515;362485;114494;25612;25649;65155;24763;681337;314304;192272;50559;170465 vnn1;trim59;top2a;sult1e1;sult1b1;srebf1;srd5a1;psat1;ppcs;pparg;polr1e;mthfd2;mrps2;mki67;mcm3;mapkapk3;kif22;igfbp3;hspd1;gcdh;ehhadh;dao;cyp2e1;crat;cdca3;cdc20;ccne2;ccna2;asns;apoa2;alas1;acsm3;acot4;acot3;acot2;acot1;acaa2 VNN1_10157;TRIM59_10085;TOP2A_10059;SULT1E1_32446;SULT1B1_32942;SREBF1_32750;SRD5A1_32503;PSAT1_9583;PPCS_9540;PPARG_32510;POLR1E_9523;MTHFD2_9261;MRPS2_9250;MKI67_9232;MCM3_9207;MAPKAPK3_9194;KIF22_8963;IGFBP3_8881;HSPD1_8849;GCDH_8693;EHHADH_8534;DAO_8437;CYP2E1_8421;CRAT_8375;CDCA3_8260;CDC20_8255;CCNE2_8227;CCNA2_8221;ASNS_8091;APOA2_33095;ALAS1_8018;ACSM3_7976;ACOT4_7971;ACOT3_7970;ACOT2_7969;ACOT1_7968;ACAA2_7955 25664(0.0441) 41.64044135135135 41.2009 3.54778 26.840425902318824 44.05794118277959 27.29462540695119 27.311431621621622 24.741 1.51564 16.70378337304049 28.61084019931422 17.035978018300767 91.22490405405406 60.0774 8.55785 100.3045956578569 97.60541619682145 104.1179465701896 20.7328;56.1278;54.9577;59.2729;15.4629;41.2009;29.2087;26.3316;15.1091;60.1903;73.982;57.4184;63.3158;49.7822;54.0045;104.193;73.9175;50.946;34.4455;15.9021;7.29984;6.1336;7.89174;8.98517;46.7245;101.569;77.8893;52.8265;28.1893;3.54778;27.1843;52.2057;12.3157;30.8838;13.6362;28.5134;78.3988 16.8296;33.6269;18.8326;45.3114;7.69418;31.4864;22.9308;20.9188;7.94061;43.9036;47.589;46.387;45.3429;35.6665;33.259;59.1667;47.5608;36.3081;26.6907;10.4227;5.26587;2.43617;4.16797;1.97988;21.1123;51.5499;49.2672;37.3288;23.1774;1.51564;21.5215;42.2655;6.70485;24.6874;11.3249;24.741;43.6084 26.7838;121.883;218.525;91.5578;35.0879;60.0774;39.9852;35.2954;30.6311;101.057;165.722;79.7903;111.245;82.1147;111.753;434.985;165.416;85.0816;48.4857;31.2818;11.8779;16.2027;15.8079;31.3726;127.486;453.17;185.461;90.0448;35.9474;8.55785;36.6615;71.1126;24.3993;41.2585;16.9658;33.4642;98.7727 24 13 24 29142;360268;64305;78968;293820;298490;25664;313245;680308;362094;63868;364975;171142;114027;25086;311849;25612;25649;65155;24763;681337;314304;192272;50559 VNN1_10157;SULT1E1_32446;SULT1B1_32942;SREBF1_32750;PSAT1_9583;PPCS_9540;PPARG_32510;POLR1E_9523;MTHFD2_9261;MRPS2_9250;HSPD1_8849;GCDH_8693;EHHADH_8534;DAO_8437;CYP2E1_8421;CRAT_8375;ASNS_8091;APOA2_33095;ALAS1_8018;ACSM3_7976;ACOT4_7971;ACOT3_7970;ACOT2_7969;ACOT1_7968 29.589617916666665 26.75795 21.099804383347088 21.679373749999996 21.22015 16.24205376969353 48.36014375 35.191649999999996 37.79406427942986 20.7328;59.2729;15.4629;41.2009;26.3316;15.1091;60.1903;73.982;57.4184;63.3158;34.4455;15.9021;7.29984;6.1336;7.89174;8.98517;28.1893;3.54778;27.1843;52.2057;12.3157;30.8838;13.6362;28.5134 16.8296;45.3114;7.69418;31.4864;20.9188;7.94061;43.9036;47.589;46.387;45.3429;26.6907;10.4227;5.26587;2.43617;4.16797;1.97988;23.1774;1.51564;21.5215;42.2655;6.70485;24.6874;11.3249;24.741 26.7838;91.5578;35.0879;60.0774;35.2954;30.6311;101.057;165.722;79.7903;111.245;48.4857;31.2818;11.8779;16.2027;15.8079;31.3726;35.9474;8.55785;36.6615;71.1126;24.3993;41.2585;16.9658;33.4642 13 365813;360243;24950;291234;316273;315994;293502;24484;297594;64515;362485;114494;170465 TRIM59_10085;TOP2A_10059;SRD5A1_32503;MKI67_9232;MCM3_9207;MAPKAPK3_9194;KIF22_8963;IGFBP3_8881;CDCA3_8260;CDC20_8255;CCNE2_8227;CCNA2_8221;ACAA2_7955 63.88811538461538 54.9577 21.93790712711852 37.70907692307692 36.3081 12.282661612557357 170.35984615384618 121.883 130.3315378073397 56.1278;54.9577;29.2087;49.7822;54.0045;104.193;73.9175;50.946;46.7245;101.569;77.8893;52.8265;78.3988 33.6269;18.8326;22.9308;35.6665;33.259;59.1667;47.5608;36.3081;21.1123;51.5499;49.2672;37.3288;43.6084 121.883;218.525;39.9852;82.1147;111.753;434.985;165.416;85.0816;127.486;453.17;185.461;90.0448;98.7727 0 Exp 2,15(0.41);Exp 4,2(0.06);Hill,6(0.17);Linear,12(0.33);Poly 2,2(0.06) 2.2195909557475746 128.2175052165985 1.5163835287094116 50.888092041015625 8.053010074317033 1.8392632007598877 32.99186523046739 50.28901747223532 21.929104883057615 32.693758360185626 58.90455511553303 123.54525299257507 UP 0.6486486486486487 0.35135135135135137 0.0 GO:0106118 8 regulation of sterol biosynthetic process 10 10 2 2 2 2 2 2 94 8 2443 0.99486 0.051951 0.051951 20.0 78968;25427 srebf1;cyp51 SREBF1_32750;CYP51_8429 58.17654999999999 58.17654999999999 41.2009 24.007194460098837 46.595152022738034 17.552430818252628 39.7922 39.7922 31.4864 11.746175006358428 34.12568500236854 8.588005754727671 115.72819999999999 115.72819999999999 60.0774 78.70211611691266 77.76122597820937 57.541644471959195 0.0 41.2009 0.0 41.2009 41.2009;75.1522 31.4864;48.098 60.0774;171.379 1 1 1 78968 SREBF1_32750 41.2009 41.2009 31.4864 31.4864 60.0774 60.0774 41.2009 31.4864 60.0774 1 25427 CYP51_8429 75.1522 75.1522 48.098 48.098 171.379 171.379 75.1522 48.098 171.379 0 Exp 2,1(0.5);Linear,1(0.5) 1.767595966704916 3.546178936958313 1.633623480796814 1.912555456161499 0.19723469127012783 1.7730894684791565 24.904275999999996 91.44882399999999 23.512832000000003 56.071568 6.652632000000011 224.80376799999996 CONFLICT 0.5 0.5 0.0 GO:0046700 5 heterocycle catabolic process 52 63 4 3 3 4 2 2 94 61 2390 0.57337 0.69555 1.0 3.17 114027;26760 dao;akr7a3 DAO_8437;AKR7A3_8015 12.4763 12.4763 6.1336 8.969932362063826 16.698566568914952 6.693625073310156 6.991535000000001 6.991535000000001 2.43617 6.442258964559715 10.023992052785923 4.807401482346556 33.9216 33.9216 16.2027 25.058308690332645 45.71687947214076 18.699240593355377 6.1336;18.819 2.43617;11.5469 16.2027;51.6405 2 0 2 114027;26760 DAO_8437;AKR7A3_8015 12.4763 12.4763 8.969932362063826 6.991535000000001 6.991535000000001 6.442258964559715 33.9216 33.9216 25.058308690332645 6.1336;18.819 2.43617;11.5469 16.2027;51.6405 0 0 Hill,1(0.5);Poly 2,1(0.5) 1.8527402189557596 3.7268584966659546 1.664124846458435 2.0627336502075195 0.28185898817163535 1.8634292483329773 0.04460800000000198 24.907991999999993 -1.9369803999999995 15.920050400000001 -0.8074440000000038 68.650644 UP 1.0 0.0 0.0 GO:0007129 6 synapsis 2 2 1 1 1 1 1 1 95 1 2450 0.99859 0.073976 0.073976 50.0 362485 ccne2 CCNE2_8227 77.8893 77.8893 77.8893 77.8893 49.2672 49.2672 49.2672 49.2672 185.461 185.461 185.461 185.461 0.0 77.8893 0.0 77.8893 77.8893 49.2672 185.461 0 1 0 1 362485 CCNE2_8227 77.8893 77.8893 49.2672 49.2672 185.461 185.461 77.8893 49.2672 185.461 0 Linear,1(1) 1.589782476425171 1.589782476425171 1.589782476425171 1.589782476425171 0.0 1.589782476425171 77.8893 77.8893 49.2672 49.2672 185.461 185.461 DOWN 0.0 1.0 0.0 GO:1903046 3 meiotic cell cycle process 29 29 3 3 3 3 3 3 93 26 2425 0.97816 0.093563 0.093563 10.34 360243;304951;362485 top2a;nuf2;ccne2 TOP2A_10059;NUF2_33136;CCNE2_8227 44.282333333333526 54.9577 5.73955E-13 40.02697032905824 44.457887093933635 37.08422345273271 22.69993333333353 18.8326 5.73955E-13 24.860238319318665 20.922894990215436 22.384910960567627 134.66200000000018 185.461 5.73957E-13 117.78666183825713 145.47069716242677 116.71914738191522 0.5 27.47885000000029 1.5 66.4235 54.9577;5.73955E-13;77.8893 18.8326;5.73955E-13;49.2672 218.525;5.73957E-13;185.461 0 3 0 3 360243;304951;362485 TOP2A_10059;NUF2_33136;CCNE2_8227 44.282333333333526 54.9577 40.02697032905824 22.69993333333353 18.8326 24.860238319318665 134.66200000000018 185.461 117.78666183825713 54.9577;5.73955E-13;77.8893 18.8326;5.73955E-13;49.2672 218.525;5.73957E-13;185.461 0 Exp 2,1(0.34);Hill,1(0.34);Linear,1(0.34) 1.7438759885378572 5.242884039878845 1.589782476425171 1.84699547290802 0.13821865116293683 1.8061060905456543 -1.0124475715472627 89.5771142382143 -5.432074626789163 50.83194129345621 1.373844598240538 267.95015540175984 DOWN 0.0 1.0 0.0 GO:0032675 6 regulation of interleukin-6 production 49 51 3 3 3 3 3 3 93 48 2403 0.87647 0.30152 0.43968 5.88 24614;63868;25599 orm1;hspd1;cd74 ORM1_9400;HSPD1_8849;CD74_8252 51.20373333333333 34.4455 24.2519 38.195612526091715 53.525584300421144 39.74678961393358 35.07286666666666 26.6907 19.7133 20.854818482627305 36.255578086102005 21.757230948214445 66.20556666666666 48.4857 31.358 46.323221091190696 68.73284865231632 48.38769247073075 1.5 64.67965 24.2519;34.4455;94.9138 19.7133;26.6907;58.8146 31.358;48.4857;118.773 3 0 3 24614;63868;25599 ORM1_9400;HSPD1_8849;CD74_8252 51.20373333333333 34.4455 38.195612526091715 35.07286666666666 26.6907 20.854818482627305 66.20556666666666 48.4857 46.323221091190696 24.2519;34.4455;94.9138 19.7133;26.6907;58.8146 31.358;48.4857;118.773 0 0 Exp 2,2(0.67);Poly 2,1(0.34) 2.142889641976067 6.898466348648071 1.6557694673538208 3.5849626064300537 1.1132534205589697 1.6577342748641968 7.9813288726820275 94.42613779398464 11.473417939569178 58.67231539376415 13.785907299876875 118.62522603345647 UP 1.0 0.0 0.0 GO:0051641 3 cellular localization 308 325 6 6 5 6 5 5 91 320 2131 0.01137 0.99627 0.019141 1.54 361604;293502;63868;24471;25599 sytl2;kif22;hspd1;hspb1;cd74 SYTL2_32351;KIF22_8963;HSPD1_8849;HSPB1_8847;CD74_8252 62.38366 67.0093 34.4455 24.616051141948024 65.30155394104503 24.760779390805336 41.690560000000005 44.4373 26.6907 12.99620485345624 43.23605279928985 13.06324646238039 106.36806000000001 118.773 48.4857 49.277348266805035 109.96587277541401 47.23699050548623 67.0093;73.9175;34.4455;41.6322;94.9138 44.4373;47.5608;26.6907;30.9494;58.8146 135.846;165.416;48.4857;63.3196;118.773 3 2 3 63868;24471;25599 HSPD1_8849;HSPB1_8847;CD74_8252 56.99716666666666 41.6322 33.03279395878185 38.81823333333333 30.9494 17.447783278208533 76.85943333333334 63.3196 37.04823140641577 34.4455;41.6322;94.9138 26.6907;30.9494;58.8146 48.4857;63.3196;118.773 2 361604;293502 SYTL2_32351;KIF22_8963 70.46340000000001 70.46340000000001 4.884835065792892 45.99905 45.99905 2.208648031036309 150.631 150.631 20.909147519686265 67.0093;73.9175 44.4373;47.5608 135.846;165.416 0 Exp 2,1(0.2);Linear,3(0.6);Poly 2,1(0.2) 1.7298672063570746 8.693294525146484 1.512166976928711 2.020775556564331 0.19749227039089626 1.6577342748641968 40.80673983312522 83.96058016687478 30.29888417927838 53.08223582072163 63.17455981360102 149.561560186399 UP 0.6 0.4 0.0 GO:0048468 4 cell development 159 163 2 2 2 2 2 2 94 161 2290 0.047501 0.98792 0.087525 1.23 65155;81633 alas1;acta2 ALAS1_8018;ACTA2_33040 58.77005 58.77005 27.1843 44.66899602772601 61.428064588452095 44.51055069329239 45.89455 45.89455 21.5215 34.46869786639756 47.94559904791155 34.34643399555654 70.11574999999999 70.11574999999999 36.6615 47.311454069020115 72.93100322481573 47.143635675298995 27.1843;90.3558 21.5215;70.2676 36.6615;103.57 1 1 1 65155 ALAS1_8018 27.1843 27.1843 21.5215 21.5215 36.6615 36.6615 27.1843 21.5215 36.6615 1 81633 ACTA2_33040 90.3558 90.3558 70.2676 70.2676 103.57 103.57 90.3558 70.2676 103.57 0 Linear,1(0.5);Poly 2,1(0.5) 1.7158002539985122 3.439888119697571 1.600624918937683 1.8392632007598877 0.16874274732718728 1.7199440598487854 -3.1380199999999974 120.67811999999999 -1.8766279999999966 93.66572799999999 4.545419999999979 135.68608 CONFLICT 0.5 0.5 0.0 GO:0071453 5 cellular response to oxygen levels 66 69 3 3 3 3 3 3 93 66 2385 0.73891 0.48662 0.74377 4.35 25664;114494;170465 pparg;ccna2;acaa2 PPARG_32510;CCNA2_8221;ACAA2_7955 25664(0.0441) 63.80519999999999 60.1903 52.8265 13.163823849094921 65.35895673937648 12.52360468482581 41.6136 43.6084 37.3288 3.713679986213158 42.49873830641012 3.1437798302286715 96.62483333333334 98.7727 90.0448 5.811810012666741 98.05306359193331 5.020825438709304 60.1903;52.8265;78.3988 43.9036;37.3288;43.6084 101.057;90.0448;98.7727 1 2 1 25664 PPARG_32510 60.1903 60.1903 43.9036 43.9036 101.057 101.057 60.1903 43.9036 101.057 2 114494;170465 CCNA2_8221;ACAA2_7955 65.61265 65.61265 18.08234674053671 40.4686 40.4686 4.440347743139048 94.40875 94.40875 6.171557275518077 52.8265;78.3988 37.3288;43.6084 90.0448;98.7727 0 Exp 2,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 1.8298274247044812 5.57826554775238 1.5239794254302979 2.3255980014801025 0.41649317662451707 1.72868812084198 48.908931004034066 78.70146899596594 37.41117548614041 45.81602451385959 90.0481511857608 103.20151548090585 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:2000026 5 regulation of multicellular organismal development 487 514 16 15 11 16 10 10 86 504 1947 0.0074285 0.99694 0.013391 1.95 29142;25664;338475;259241;24471;102551184;58868;64515;25599;502970 vnn1;pparg;nrep;nr1d2;hspb1;loc102551184;fzd1;cdc20;cd74;angptl3 VNN1_10157;PPARG_32510;NREP_9364;NR1D2_9358;HSPB1_8847;HIST1H4A_32934;FZD1_8671;CDC20_8255;CD74_8252;ANGPTL3_8045 25664(0.0441) 62.91061 59.2603 20.7328 28.998717063018493 65.59120548948668 25.924494922359855 38.17112999999999 41.38125 13.6792 14.131240253742783 40.82877326539385 13.088921462246182 136.65583999999998 105.507 26.7838 116.8003848512229 138.2638570763334 108.10778462249407 20.7328;60.1903;69.4104;99.0234;41.6322;58.3303;25.231;101.569;94.9138;58.0729 16.8296;43.9036;43.1468;42.5557;30.9494;40.2068;13.6792;51.5499;58.8146;40.0757 26.7838;101.057;157.944;102.838;63.3196;105.902;131.659;453.17;118.773;105.112 7 3 7 29142;25664;259241;24471;58868;25599;502970 VNN1_10157;PPARG_32510;NR1D2_9358;HSPB1_8847;FZD1_8671;CD74_8252;ANGPTL3_8045 57.11377142857143 58.0729 31.02528359422974 35.25825714285714 40.0757 15.968411687856031 92.79177142857142 102.838 35.898875608284 20.7328;60.1903;99.0234;41.6322;25.231;94.9138;58.0729 16.8296;43.9036;42.5557;30.9494;13.6792;58.8146;40.0757 26.7838;101.057;102.838;63.3196;131.659;118.773;105.112 3 338475;102551184;64515 NREP_9364;HIST1H4A_32934;CDC20_8255 76.43656666666668 69.4104 22.459331199822742 44.96783333333334 43.1468 5.886730943684493 239.00533333333337 157.944 187.28846941905772 69.4104;58.3303;101.569 43.1468;40.2068;51.5499 157.944;105.902;453.17 0 Exp 2,3(0.3);Linear,4(0.4);Poly 2,2(0.2);Power,1(0.1) 1.9423830754367386 20.813238978385925 1.5124053955078125 4.608505725860596 0.9702088540231847 1.6565749049186707 44.93701895218232 80.8842010478177 29.41249654848295 46.92976345151705 64.26221144803812 209.04946855196192 UP 0.7 0.3 0.0 GO:0000187 10 activation of MAPK activity 35 38 2 2 2 2 2 2 94 36 2415 0.82951 0.42312 0.65285 5.26 29455;25599 gdf15;cd74 GDF15_33113;CD74_8252 58.1396 58.1396 21.3654 52.00657238542067 85.25264702586206 35.134725461098824 38.35105 38.35105 17.8875 28.939829944299937 53.43850787715517 19.551240032671537 72.5629 72.5629 26.3528 65.35095013861695 106.63288967672413 44.14995233152375 0.5 58.1396 21.3654;94.9138 17.8875;58.8146 26.3528;118.773 2 0 2 29455;25599 GDF15_33113;CD74_8252 58.1396 58.1396 52.00657238542067 38.35105 38.35105 28.939829944299937 72.5629 72.5629 65.35095013861695 21.3654;94.9138 17.8875;58.8146 26.3528;118.773 0 0 Exp 2,1(0.5);Poly 2,1(0.5) 2.8833405237034424 6.67280375957489 1.6577342748641968 5.015069484710693 2.3739944935988184 3.336401879787445 -13.937831999999993 130.217032 -1.7575079999999872 78.45960799999999 -18.008895999999993 163.134696 UP 1.0 0.0 0.0 GO:0002711 9 positive regulation of T cell mediated immunity 19 26 2 2 2 2 2 2 94 24 2427 0.92789 0.25657 0.25657 7.69 309607;63868 rt1-ce5;hspd1 RT1-CE5_32445;HSPD1_8849 44.63305 44.63305 34.4455 14.407371377354051 45.188256125699525 14.38595990266107 26.64045 26.64045 26.5902 0.07106423150782569 26.63771145071028 0.07095861960490678 98.15485000000001 98.15485000000001 48.4857 70.24278556154361 100.86174383986226 70.13839444216292 0.5 44.63305 54.8206;34.4455 26.5902;26.6907 147.824;48.4857 1 1 1 63868 HSPD1_8849 34.4455 34.4455 26.6907 26.6907 48.4857 48.4857 34.4455 26.6907 48.4857 1 309607 RT1-CE5_32445 54.8206 54.8206 26.5902 26.5902 147.824 147.824 54.8206 26.5902 147.824 0 Exp 2,2(1) 1.7490287420993837 3.503310203552246 1.6557694673538208 1.8475407361984253 0.13560276463676832 1.751655101776123 24.665452000000002 64.60064799999999 26.54196 26.738940000000003 0.8033160000000237 195.506384 CONFLICT 0.5 0.5 0.0 GO:0050804 6 modulation of chemical synaptic transmission 117 127 4 4 2 3 2 2 94 125 2326 0.1321 0.95821 0.23464 1.57 24679;64515 prkar2b;cdc20 PRKAR2B_33052;CDC20_8255 105.1575 105.1575 101.569 5.074905368575514 104.45209798479547 4.975889919791476 55.46565 55.46565 51.5499 5.5377067568624625 54.69591948835526 5.429661684109452 300.31850000000003 300.31850000000003 147.467 216.16466432907112 330.36496959092557 211.9471194301615 108.746;101.569 59.3814;51.5499 147.467;453.17 1 1 1 24679 PRKAR2B_33052 108.746 108.746 59.3814 59.3814 147.467 147.467 108.746 59.3814 147.467 1 64515 CDC20_8255 101.569 101.569 51.5499 51.5499 453.17 453.17 101.569 51.5499 453.17 0 Exp 2,1(0.5);Power,1(0.5) 1.574406950200013 3.1501418352127075 1.5293418169021606 1.6208000183105469 0.06467071441099495 1.5750709176063538 98.12404000000001 112.19095999999999 47.79078 63.140519999999995 0.7295599999999922 599.90744 CONFLICT 0.5 0.5 0.0 GO:1901361 5 organic cyclic compound catabolic process 75 89 8 7 7 8 6 6 90 83 2368 0.952 0.11613 0.1469 6.74 286954;360268;24950;65030;114027;26760 ugt2b1;sult1e1;srd5a1;ephx2;dao;akr7a3 UGT2B10_33303,UGT2B1_33224;SULT1E1_32446;SRD5A1_32503;EPHX2_33282;DAO_8437;AKR7A3_8015 22.069966666666662 15.681574999999999 6.1336 20.172000621546363 26.14928390675952 22.202040677732683 15.372880833333335 9.4475725 2.43617 16.500605849341536 18.46365094926215 18.114266278847683 40.37155833333333 32.740525 16.2027 28.575186922790483 48.164100467031446 30.795170955748734 3.5 24.013849999999998 12.54415;59.2729;29.2087;6.44145;6.1336;18.819 7.348245;45.3114;22.9308;2.66377;2.43617;11.5469 25.495849999999997;91.5578;39.9852;17.3473;16.2027;51.6405 6 1 5 286954;360268;65030;114027;26760 UGT2B10_33303,UGT2B1_33224;SULT1E1_32446;EPHX2_33282;DAO_8437;AKR7A3_8015 20.64222 12.54415 22.211451039120565 13.861297000000002 7.348245 17.977787658808158 40.44883 25.495849999999997 31.947329352576563 12.54415;59.2729;6.44145;6.1336;18.819 7.348245;45.3114;2.66377;2.43617;11.5469 25.495849999999997;91.5578;17.3473;16.2027;51.6405 1 24950 SRD5A1_32503 29.2087 29.2087 22.9308 22.9308 39.9852 39.9852 29.2087 22.9308 39.9852 0 Exp 2,1(0.15);Exp 4,2(0.29);Hill,1(0.15);Linear,1(0.15);Poly 2,2(0.29) 2.009878536521923 14.362786293029785 1.635288953781128 2.9455835819244385 0.47263221368518227 1.9512832164764404 5.92900451946139 38.210928813871945 2.169646339294397 28.57611532737227 17.50664675994081 63.23646990672586 UP 0.8333333333333334 0.16666666666666666 0.0 GO:0050870 8 positive regulation of T cell activation 64 67 3 3 3 3 3 3 93 64 2387 0.75567 0.46693 0.73911 4.48 29142;63868;25599 vnn1;hspd1;cd74 VNN1_10157;HSPD1_8849;CD74_8252 50.0307 34.4455 20.7328 39.46997636850064 63.16485878237852 39.878983102633505 34.11163333333334 26.6907 16.8296 21.954219296147446 41.572045648200664 21.80588686686313 64.68083333333333 48.4857 26.7838 48.08549663800233 81.02783315686646 47.74266808600099 20.7328;34.4455;94.9138 16.8296;26.6907;58.8146 26.7838;48.4857;118.773 3 0 3 29142;63868;25599 VNN1_10157;HSPD1_8849;CD74_8252 50.0307 34.4455 39.46997636850064 34.11163333333334 26.6907 21.954219296147446 64.68083333333333 48.4857 48.08549663800233 20.7328;34.4455;94.9138 16.8296;26.6907;58.8146 26.7838;48.4857;118.773 0 0 Exp 2,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 2.3300127958536945 7.922009468078613 1.6557694673538208 4.608505725860596 1.7041961657814189 1.6577342748641968 5.366217096726444 94.69518290327355 9.268095469194861 58.9551711974718 10.266971454321045 119.09469521234561 UP 1.0 0.0 0.0 GO:0003013 4 circulatory system process 81 84 2 2 2 2 2 2 94 82 2369 0.37822 0.83458 0.7693 2.38 298490;81633 ppcs;acta2 PPCS_9540;ACTA2_33040 52.73245 52.73245 15.1091 53.20745183190979 54.88460928421683 53.12032898312772 39.104105000000004 39.104105000000004 7.94061 44.07183727994614 40.88674277927523 43.99967325248963 67.10055 67.10055 30.6311 51.575590802287465 69.18670302485774 51.491139992417644 15.1091;90.3558 7.94061;70.2676 30.6311;103.57 1 1 1 298490 PPCS_9540 15.1091 15.1091 7.94061 7.94061 30.6311 30.6311 15.1091 7.94061 30.6311 1 81633 ACTA2_33040 90.3558 90.3558 70.2676 70.2676 103.57 103.57 90.3558 70.2676 103.57 0 Hill,1(0.5);Poly 2,1(0.5) 1.7447692801539834 3.5025194883346558 1.600624918937683 1.9018945693969727 0.2130298128054645 1.7512597441673279 -21.009316 126.474216 -21.97634519999999 100.1845552 -4.379571999999982 138.580672 CONFLICT 0.5 0.5 0.0 GO:0042594 4 response to starvation 75 79 5 5 4 5 4 4 92 75 2376 0.82517 0.34739 0.53955 5.06 78968;24950;25664;25612 srebf1;srd5a1;pparg;asns SREBF1_32750;SRD5A1_32503;PPARG_32510;ASNS_8091 25664(0.0441) 39.6973 35.2048 28.1893 14.88476464845851 44.26413435427074 14.656873021830695 30.37455 27.331899999999997 22.9308 9.856973614485668 33.40001900745229 9.7089781376213 59.26675 50.0313 35.9474 29.791790834109538 68.11686230447957 29.67823126870554 2.5 50.6956 41.2009;29.2087;60.1903;28.1893 31.4864;22.9308;43.9036;23.1774 60.0774;39.9852;101.057;35.9474 3 1 3 78968;25664;25612 SREBF1_32750;PPARG_32510;ASNS_8091 43.1935 41.2009 16.09328559741609 32.855799999999995 31.4864 10.430737456191679 65.69393333333333 60.0774 32.91616757846111 41.2009;60.1903;28.1893 31.4864;43.9036;23.1774 60.0774;101.057;35.9474 1 24950 SRD5A1_32503 29.2087 29.2087 22.9308 22.9308 39.9852 39.9852 29.2087 22.9308 39.9852 0 Exp 2,3(0.75);Linear,1(0.25) 2.0752252062132017 8.64879322052002 1.5239794254302979 3.2609751224517822 0.7575047985220461 1.9319193363189697 25.110230644510665 54.28436935548933 20.714715857804045 40.034384142195954 30.070794982572654 88.46270501742735 UP 0.75 0.25 0.0 GO:0051302 5 regulation of cell division 50 51 3 3 2 3 2 2 94 49 2402 0.69848 0.58009 0.71826 3.92 308761;303575 prc1;kif18b PRC1_9556;KIF18B_32882 73.1414 73.1414 65.9823 10.12449631438505 71.32587284172662 9.793525815309987 47.114149999999995 47.114149999999995 43.9552 4.467429932858555 46.3130493705036 4.321389333054898 165.4455 165.4455 131.93 47.39807464971543 156.94606564748202 45.848628244195886 80.3005;65.9823 50.2731;43.9552 198.961;131.93 0 2 0 2 308761;303575 PRC1_9556;KIF18B_32882 73.1414 73.1414 10.12449631438505 47.114149999999995 47.114149999999995 4.467429932858555 165.4455 165.4455 47.39807464971543 80.3005;65.9823 50.2731;43.9552 198.961;131.93 0 Linear,2(1) 1.7605050140832308 3.5218164920806885 1.7232260704040527 1.7985904216766357 0.053290643844568455 1.7609082460403442 59.109564 87.173236 40.922608 53.30569199999999 99.75512 231.13588000000001 DOWN 0.0 1.0 0.0 GO:0001889 6 liver development 91 101 6 6 4 5 4 4 92 97 2354 0.66823 0.53433 0.79073 3.96 24950;25315;24303;25612 srd5a1;ephx1;cyp2d3;asns SRD5A1_32503;EPHX1_8567;CYP2D3_8420;ASNS_8091 26.054325 28.698999999999998 12.8059 9.190136736877214 23.509741190476188 10.580638343114128 20.283125000000002 23.0541 8.8664 7.7511633902595545 17.990729217687075 8.904539884620704 36.725274999999996 37.966300000000004 22.6004 10.743985422357651 34.31868565111759 12.219048486246585 29.2087;34.0134;12.8059;28.1893 22.9308;26.1579;8.8664;23.1774 39.9852;48.3681;22.6004;35.9474 3 1 3 25315;24303;25612 EPHX1_8567;CYP2D3_8420;ASNS_8091 25.002866666666666 28.1893 10.956939905983484 19.400566666666666 23.1774 9.243773341192078 35.63863333333333 35.9474 12.886624595421946 34.0134;12.8059;28.1893 26.1579;8.8664;23.1774 48.3681;22.6004;35.9474 1 24950 SRD5A1_32503 29.2087 29.2087 22.9308 22.9308 39.9852 39.9852 29.2087 22.9308 39.9852 0 Exp 2,1(0.25);Linear,2(0.5);Poly 2,1(0.25) 2.1221693373574393 8.806062459945679 1.5935766696929932 3.2609751224517822 0.729195307001193 1.9757553339004517 17.04799099786034 35.06065900213966 12.686984877545637 27.879265122454367 26.196169286089518 47.25438071391048 UP 0.75 0.25 0.0 GO:1903202 7 negative regulation of oxidative stress-induced cell death 25 26 3 3 3 3 3 3 93 23 2428 0.98502 0.07211 0.07211 11.54 29142;24471;58868 vnn1;hspb1;fzd1 VNN1_10157;HSPB1_8847;FZD1_8671 29.198666666666668 25.231 20.7328 11.00013700702556 31.85877353288696 11.08507218582006 20.48606666666667 16.8296 13.6792 9.19740525220746 22.096362583694365 9.98041154594139 73.9208 63.3196 26.7838 53.23524185011278 81.5004549822765 49.15265638737312 0.5 22.981900000000003 1.5 33.4316 20.7328;41.6322;25.231 16.8296;30.9494;13.6792 26.7838;63.3196;131.659 3 0 3 29142;24471;58868 VNN1_10157;HSPB1_8847;FZD1_8671 29.198666666666668 25.231 11.00013700702556 20.48606666666667 16.8296 9.19740525220746 73.9208 63.3196 53.23524185011278 20.7328;41.6322;25.231 16.8296;30.9494;13.6792 26.7838;63.3196;131.659 0 0 Linear,2(0.67);Poly 2,1(0.34) 2.3436163573382798 7.967759370803833 1.5124053955078125 4.608505725860596 1.6992371472344534 1.8468482494354248 16.75083982489388 41.64649350843945 10.078222846178878 30.893910487154454 13.679452823426594 134.1621471765734 UP 1.0 0.0 0.0 GO:0044282 4 small molecule catabolic process 107 120 18 18 15 18 15 15 81 105 2346 0.99999 2.6909E-5 2.6909E-5 12.5 360268;64305;364975;171142;291075;29740;64526;117543;114027;311849;25413;50681;681337;192272;170465 sult1e1;sult1b1;gcdh;ehhadh;eci2;eci1;ech1;decr1;dao;crat;cpt2;acox1;acot4;acot2;acaa2 SULT1E1_32446;SULT1B1_32942;GCDH_8693;EHHADH_8534;ECI2_8521;ECI1_8520;ECH1_8516;DECR1_8458;DAO_8437;CRAT_8375;CPT2_8374;ACOX1_7973;ACOT4_7971;ACOT2_7969;ACAA2_7955 21.627654 13.6362 6.1336 20.64174333035498 25.085186940334307 23.07944079614732 14.418587333333333 8.40998 1.97988 13.73939239820018 16.69057514790352 15.411454612402292 34.336980000000004 28.0829 11.8779 26.078791506569903 39.430950396664315 29.52886204318524 5.0 11.7653 11.0 23.8014 59.2729;15.4629;15.9021;7.29984;8.72912;11.7653;9.87438;21.6199;6.1336;8.98517;31.2175;23.8014;12.3157;13.6362;78.3988 45.3114;7.69418;10.4227;5.26587;5.10151;8.40998;6.59127;17.4928;2.43617;1.97988;24.8356;19.0993;6.70485;11.3249;43.6084 91.5578;35.0879;31.2818;11.8779;17.7951;18.8402;19.44;28.0829;16.2027;31.3726;42.0237;31.3543;24.3993;16.9658;98.7727 14 1 14 360268;64305;364975;171142;291075;29740;64526;117543;114027;311849;25413;50681;681337;192272 SULT1E1_32446;SULT1B1_32942;GCDH_8693;EHHADH_8534;ECI2_8521;ECI1_8520;ECH1_8516;DECR1_8458;DAO_8437;CRAT_8375;CPT2_8374;ACOX1_7973;ACOT4_7971;ACOT2_7969 17.572572142857144 12.975950000000001 13.900656558153138 12.333600714285714 8.05208 11.535520782036981 29.734428571428573 26.2411 19.754096757476304 59.2729;15.4629;15.9021;7.29984;8.72912;11.7653;9.87438;21.6199;6.1336;8.98517;31.2175;23.8014;12.3157;13.6362 45.3114;7.69418;10.4227;5.26587;5.10151;8.40998;6.59127;17.4928;2.43617;1.97988;24.8356;19.0993;6.70485;11.3249 91.5578;35.0879;31.2818;11.8779;17.7951;18.8402;19.44;28.0829;16.2027;31.3726;42.0237;31.3543;24.3993;16.9658 1 170465 ACAA2_7955 78.3988 78.3988 43.6084 43.6084 98.7727 98.7727 78.3988 43.6084 98.7727 0 Exp 2,2(0.14);Exp 4,1(0.07);Hill,6(0.4);Linear,3(0.2);Poly 2,3(0.2) 2.289420955112761 36.879462361335754 1.5464483499526978 4.473705768585205 1.002124352925364 1.8769218921661377 11.181490587726692 32.07381741227331 7.465495441822226 21.371679224844442 21.13929057462967 47.534669425370325 UP 0.9333333333333333 0.06666666666666667 0.0 GO:1901607 7 alpha-amino acid biosynthetic process 18 19 2 2 2 2 2 2 94 17 2434 0.96756 0.15902 0.15902 10.53 293820;25612 psat1;asns PSAT1_9583;ASNS_8091 27.26045 27.26045 26.3316 1.313592267410317 27.14314508556074 1.3030747327367378 22.048099999999998 22.048099999999998 20.9188 1.597071375987983 21.905480158393434 1.5842841101141998 35.6214 35.6214 35.2954 0.46103362133407844 35.58022930278602 0.4573422650294195 0.0 26.3316 0.5 27.26045 26.3316;28.1893 20.9188;23.1774 35.2954;35.9474 2 0 2 293820;25612 PSAT1_9583;ASNS_8091 27.26045 27.26045 1.313592267410317 22.048099999999998 22.048099999999998 1.597071375987983 35.6214 35.6214 0.46103362133407844 26.3316;28.1893 20.9188;23.1774 35.2954;35.9474 0 0 Exp 2,1(0.5);Linear,1(0.5) 2.9243221153511385 5.883399248123169 2.6224241256713867 3.2609751224517822 0.4515237399568469 2.9416996240615845 25.439904000000002 29.080995999999995 19.834672 24.261527999999995 34.98244 36.260360000000006 UP 1.0 0.0 0.0 GO:0045471 5 response to ethanol 109 117 6 6 5 5 4 4 92 113 2338 0.54609 0.65269 1.0 3.42 286954;78968;25086;65155 ugt2b1;srebf1;cyp2e1;alas1 UGT2B10_33303,UGT2B1_33224;SREBF1_32750;CYP2E1_8421;ALAS1_8018 22.2052725 19.864225 7.89174 15.097892563236265 25.212178106981888 16.1095436957864 16.13102875 14.4348725 4.16797 12.716087862462768 18.517352529551832 13.438165021372042 34.510662499999995 31.078674999999997 15.8079 19.055570820514014 38.72838531337699 20.620520102765298 12.54415;41.2009;7.89174;27.1843 7.348245;31.4864;4.16797;21.5215 25.495849999999997;60.0774;15.8079;36.6615 5 0 4 286954;78968;25086;65155 UGT2B10_33303,UGT2B1_33224;SREBF1_32750;CYP2E1_8421;ALAS1_8018 22.2052725 19.864225 15.097892563236265 16.13102875 14.4348725 12.716087862462768 34.510662499999995 31.078674999999997 19.055570820514014 12.54415;41.2009;7.89174;27.1843 7.348245;31.4864;4.16797;21.5215 25.495849999999997;60.0774;15.8079;36.6615 0 0 Exp 2,1(0.2);Exp 4,2(0.4);Linear,1(0.2);Poly 2,1(0.2) 1.7241169868725468 8.64794671535492 1.5310101509094238 1.912555456161499 0.15315945122065386 1.729828953742981 7.409337788028459 37.00120721197154 3.669262644786489 28.59279485521351 15.83620309589627 53.18512190410374 UP 1.0 0.0 0.0 GO:0070988 3 demethylation 11 12 2 2 2 2 2 2 94 10 2441 0.99109 0.072579 0.072579 16.67 25427;266682 cyp51;cyp3a2 CYP51_8429;CYP3A2_32374 49.20035 49.20035 23.2485 36.7014582386722 32.79786970927043 28.44141904809703 33.39675 33.39675 18.6955 20.79070713383746 24.105043883708174 16.11154548831147 100.94675 100.94675 30.5145 99.60624317845243 56.43109533735601 77.18883766476497 0.0 23.2485 0.5 49.20035 75.1522;23.2485 48.098;18.6955 171.379;30.5145 1 1 1 266682 CYP3A2_32374 23.2485 23.2485 18.6955 18.6955 30.5145 30.5145 23.2485 18.6955 30.5145 1 25427 CYP51_8429 75.1522 75.1522 48.098 48.098 171.379 171.379 75.1522 48.098 171.379 0 Linear,2(1) 2.480442328718731 5.399848818778992 1.633623480796814 3.7662253379821777 1.507977234786796 2.699924409389496 -1.6652759999999844 100.06597599999998 4.5823 62.21119999999999 -37.100459999999984 238.99395999999996 CONFLICT 0.5 0.5 0.0 GO:0002701 7 negative regulation of production of molecular mediator of immune response 11 12 3 3 2 3 2 2 94 10 2441 0.99109 0.072579 0.072579 16.67 309607;25649 rt1-ce5;apoa2 RT1-CE5_32445;APOA2_33095 29.18419 29.18419 3.54778 36.25535871255723 29.397351884415905 36.254105414397756 14.05292 14.05292 1.51564 17.730391411268958 14.157165104140939 17.729778495890052 78.19092500000001 78.19092500000001 8.55785 98.47603905474291 78.76991080513709 98.4726348727714 0.0 3.54778 0.5 29.18419 54.8206;3.54778 26.5902;1.51564 147.824;8.55785 1 1 1 25649 APOA2_33095 3.54778 3.54778 1.51564 1.51564 8.55785 8.55785 3.54778 1.51564 8.55785 1 309607 RT1-CE5_32445 54.8206 54.8206 26.5902 26.5902 147.824 147.824 54.8206 26.5902 147.824 0 Exp 2,1(0.5);Hill,1(0.5) 1.7858672116510428 3.5737931728363037 1.7262524366378784 1.8475407361984253 0.08576377909784805 1.7868965864181519 -21.063173599999992 79.4315536 -10.520148799999998 38.6259888 -58.289902 214.67175200000003 CONFLICT 0.5 0.5 0.0 GO:0002719 7 negative regulation of cytokine production involved in immune response 11 12 3 3 2 3 2 2 94 10 2441 0.99109 0.072579 0.072579 16.67 309607;25649 rt1-ce5;apoa2 RT1-CE5_32445;APOA2_33095 29.18419 29.18419 3.54778 36.25535871255723 29.397351884415905 36.254105414397756 14.05292 14.05292 1.51564 17.730391411268958 14.157165104140939 17.729778495890052 78.19092500000001 78.19092500000001 8.55785 98.47603905474291 78.76991080513709 98.4726348727714 0.0 3.54778 0.5 29.18419 54.8206;3.54778 26.5902;1.51564 147.824;8.55785 1 1 1 25649 APOA2_33095 3.54778 3.54778 1.51564 1.51564 8.55785 8.55785 3.54778 1.51564 8.55785 1 309607 RT1-CE5_32445 54.8206 54.8206 26.5902 26.5902 147.824 147.824 54.8206 26.5902 147.824 0 Exp 2,1(0.5);Hill,1(0.5) 1.7858672116510428 3.5737931728363037 1.7262524366378784 1.8475407361984253 0.08576377909784805 1.7868965864181519 -21.063173599999992 79.4315536 -10.520148799999998 38.6259888 -58.289902 214.67175200000003 CONFLICT 0.5 0.5 0.0 GO:0009267 5 cellular response to starvation 53 55 4 4 3 4 3 3 93 52 2399 0.84908 0.34353 0.46162 5.45 78968;24950;25612 srebf1;srd5a1;asns SREBF1_32750;SRD5A1_32503;ASNS_8091 32.866299999999995 29.2087 28.1893 7.235949278429226 35.71117498269243 7.57715068298169 25.864866666666668 23.1774 22.9308 4.8699518122188135 27.759194751085655 5.137811270974725 45.336666666666666 39.9852 35.9474 12.924506629397245 50.42674996538485 13.400166498249801 1.5 35.2048 41.2009;29.2087;28.1893 31.4864;22.9308;23.1774 60.0774;39.9852;35.9474 2 1 2 78968;25612 SREBF1_32750;ASNS_8091 34.6951 34.6951 9.20059059408691 27.331899999999997 27.331899999999997 5.8753502448790345 48.0124 48.0124 17.062486630031398 41.2009;28.1893 31.4864;23.1774 60.0774;35.9474 1 24950 SRD5A1_32503 29.2087 29.2087 22.9308 22.9308 39.9852 39.9852 29.2087 22.9308 39.9852 0 Exp 2,2(0.67);Linear,1(0.34) 2.3001735783708996 7.124813795089722 1.912555456161499 3.2609751224517822 0.7675750044170204 1.9512832164764404 24.678052563062593 41.0545474369374 20.35399740680559 31.375735926527746 30.711210598680484 59.96212273465285 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0002694 5 regulation of leukocyte activation 146 156 6 6 5 6 5 5 91 151 2300 0.45794 0.71179 1.0 3.21 29142;309607;25664;63868;25599 vnn1;rt1-ce5;pparg;hspd1;cd74 VNN1_10157;RT1-CE5_32445;PPARG_32510;HSPD1_8849;CD74_8252 25664(0.0441) 53.0206 54.8206 20.7328 28.271987784642945 60.65921892936705 26.487958537312068 34.56574 26.6907 16.8296 16.698794837292894 39.21803996527322 16.038726797238507 88.58470000000001 101.057 26.7838 50.008667824888114 100.02824615712227 42.370229839180354 20.7328;54.8206;60.1903;34.4455;94.9138 16.8296;26.5902;43.9036;26.6907;58.8146 26.7838;147.824;101.057;48.4857;118.773 4 1 4 29142;25664;63868;25599 VNN1_10157;PPARG_32510;HSPD1_8849;CD74_8252 52.5706 47.3179 32.62499641471245 36.559625 35.29715 18.582137015670906 73.77487500000001 74.77135 43.269885986551486 20.7328;60.1903;34.4455;94.9138 16.8296;43.9036;26.6907;58.8146 26.7838;101.057;48.4857;118.773 1 309607 RT1-CE5_32445 54.8206 54.8206 26.5902 26.5902 147.824 147.824 54.8206 26.5902 147.824 0 Exp 2,3(0.6);Linear,1(0.2);Poly 2,1(0.2) 2.0432881154372655 11.293529629707336 1.5239794254302979 4.608505725860596 1.3186298041909403 1.6577342748641968 28.23911007416192 77.80208992583809 19.928600963784287 49.202879036215705 44.75016995750269 132.4192300424973 UP 0.8 0.2 0.0 GO:0018130 5 heterocycle biosynthetic process 162 180 8 8 6 8 6 6 90 174 2277 0.4757 0.68441 1.0 3.33 78968;298490;313245;296371;364975;65155 srebf1;ppcs;polr1e;pltp;gcdh;alas1 SREBF1_32750;PPCS_9540;POLR1E_9523;PLTP_32412;GCDH_8693;ALAS1_8018 43.400666666666666 34.1926 15.1091 30.537669168465793 44.70809342576622 29.881779098243122 29.264468333333337 26.50395 7.94061 19.79436494175088 30.718757264826856 19.357653969349318 71.48946666666666 48.36945 30.6311 54.04241678302951 65.02689527331829 40.531329877618425 41.2009;15.1091;73.982;87.0256;15.9021;27.1843 31.4864;7.94061;47.589;56.6266;10.4227;21.5215 60.0774;30.6311;165.722;104.563;31.2818;36.6615 6 0 6 78968;298490;313245;296371;364975;65155 SREBF1_32750;PPCS_9540;POLR1E_9523;PLTP_32412;GCDH_8693;ALAS1_8018 43.400666666666666 34.1926 30.537669168465793 29.264468333333337 26.50395 19.79436494175088 71.48946666666666 48.36945 54.04241678302951 41.2009;15.1091;73.982;87.0256;15.9021;27.1843 31.4864;7.94061;47.589;56.6266;10.4227;21.5215 60.0774;30.6311;165.722;104.563;31.2818;36.6615 0 0 Exp 2,1(0.17);Hill,1(0.17);Linear,2(0.34);Poly 2,2(0.34) 1.694795822601649 10.227037787437439 1.5084086656570435 1.912555456161499 0.19922500772641466 1.6928557753562927 18.96544225042339 67.83589108290994 13.425677662689589 45.10325900397708 28.24652710882023 114.73240622451311 UP 1.0 0.0 0.0 GO:0001558 5 regulation of cell growth 111 120 6 6 3 6 3 3 93 117 2334 0.32743 0.84095 0.6246 2.5 25664;24484;25685 pparg;igfbp3;igfbp1 PPARG_32510;IGFBP3_8881;IGFBP1_32306 25664(0.0441) 69.99113333333334 60.1903 50.946 25.405346195699284 61.230485474036854 16.545782326930517 45.84656666666667 43.9036 36.3081 10.64379577985846 42.84487760134003 7.38684269285782 181.18253333333334 101.057 85.0816 152.82548549457755 122.64301892127303 98.56527320104031 60.1903;50.946;98.8371 43.9036;36.3081;57.328 101.057;85.0816;357.409 2 1 2 25664;25685 PPARG_32510;IGFBP1_32306 79.5137 79.5137 27.32741435116028 50.6158 50.6158 9.492484273360676 229.233 229.233 181.26823757073387 60.1903;98.8371 43.9036;57.328 101.057;357.409 1 24484 IGFBP3_8881 50.946 50.946 36.3081 36.3081 85.0816 85.0816 50.946 36.3081 85.0816 0 Exp 2,1(0.34);Linear,2(0.67) 1.7524538298533374 5.29391872882843 1.5239794254302979 2.031935214996338 0.2550232498207629 1.7380040884017944 41.24227774204577 98.7399889246209 33.8019778836133 57.89115544972004 8.244216362247272 354.1208503044194 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0015850 6 organic hydroxy compound transport 49 50 5 5 3 5 3 3 93 47 2404 0.88295 0.29105 0.43474 6.0 25649;114628;140668 apoa2;abcg5;abcc3 APOA2_33095;ABCG5_7947;ABCC3_7941 23.812393333333336 33.1119 3.54778 17.569418630169103 24.089754216625217 17.22573248707286 17.46054666666667 24.2098 1.51564 13.862765045131987 17.564471925498705 13.495080338947247 36.25375 49.7705 8.55785 23.98763954722308 36.9285837636912 23.766842186510758 1.5 33.9447 3.54778;33.1119;34.7775 1.51564;24.2098;26.6562 8.55785;50.4329;49.7705 2 1 2 25649;140668 APOA2_33095;ABCC3_7941 19.162640000000003 19.162640000000003 22.082746786557152 14.08592 14.08592 17.77706045882727 29.164175 29.164175 29.14174428566777 3.54778;34.7775 1.51564;26.6562 8.55785;49.7705 1 114628 ABCG5_7947 33.1119 33.1119 24.2098 24.2098 50.4329 50.4329 33.1119 24.2098 50.4329 0 Exp 2,1(0.34);Hill,1(0.34);Linear,1(0.34) 2.059307611922591 6.25624942779541 1.7262524366378784 2.5319817066192627 0.40991357664627376 1.998015284538269 3.930724525091943 43.69406214157473 1.773351250848469 33.14774208248486 9.109180506366616 63.39831949363338 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0019216 6 regulation of lipid metabolic process 132 142 12 12 8 12 8 8 88 134 2317 0.91651 0.16304 0.25042 5.63 78968;25664;259241;65030;25427;25599;25649;502970 srebf1;pparg;nr1d2;ephx2;cyp51;cd74;apoa2;angptl3 SREBF1_32750;PPARG_32510;NR1D2_9358;EPHX2_33282;CYP51_8429;CD74_8252;APOA2_33095;ANGPTL3_8045 25664(0.0441) 54.817841249999994 59.1316 3.54778 36.19210193773398 51.65714089683164 33.940543572641744 33.63917625 41.3157 1.51564 20.925660914819353 33.366581854075484 20.610294876468995 85.64269375 101.94749999999999 8.55785 54.27520200610189 78.85811539763588 46.01831616258126 6.5 96.9686 41.2009;60.1903;99.0234;6.44145;75.1522;94.9138;3.54778;58.0729 31.4864;43.9036;42.5557;2.66377;48.098;58.8146;1.51564;40.0757 60.0774;101.057;102.838;17.3473;171.379;118.773;8.55785;105.112 7 1 7 78968;25664;259241;65030;25599;25649;502970 SREBF1_32750;PPARG_32510;NR1D2_9358;EPHX2_33282;CD74_8252;APOA2_33095;ANGPTL3_8045 51.91293285714285 58.0729 38.071253598853616 31.573629999999998 40.0757 21.703532890769196 73.39465 101.057 45.129012527632 41.2009;60.1903;99.0234;6.44145;94.9138;3.54778;58.0729 31.4864;43.9036;42.5557;2.66377;58.8146;1.51564;40.0757 60.0774;101.057;102.838;17.3473;118.773;8.55785;105.112 1 25427 CYP51_8429 75.1522 75.1522 48.098 48.098 171.379 171.379 75.1522 48.098 171.379 0 Exp 2,2(0.25);Exp 4,1(0.13);Hill,1(0.13);Linear,2(0.25);Poly 2,1(0.13);Power,1(0.13) 1.847337188402397 15.092733144760132 1.5239794254302979 2.7270524501800537 0.4375132927754355 1.6919933557510376 29.73799415854486 79.89768834145514 19.13843305099452 48.139919449005475 48.031897628991324 123.2534898710087 UP 0.875 0.125 0.0 GO:0007018 4 microtubule-based movement 28 32 3 3 3 3 3 3 93 29 2422 0.96965 0.11731 0.11731 9.38 293502;303575;24471 kif22;kif18b;hspb1 KIF22_8963;KIF18B_32882;HSPB1_8847 60.51066666666666 65.9823 41.6322 16.823769717971487 61.775118743529404 15.597728136355935 40.8218 43.9552 30.9494 8.737751378930389 41.516797054117646 8.112388667087217 120.22186666666668 131.93 63.3196 52.045451413676176 123.43941684705884 48.124458488963754 0.5 53.807249999999996 73.9175;65.9823;41.6322 47.5608;43.9552;30.9494 165.416;131.93;63.3196 1 2 1 24471 HSPB1_8847 41.6322 41.6322 30.9494 30.9494 63.3196 63.3196 41.6322 30.9494 63.3196 2 293502;303575 KIF22_8963;KIF18B_32882 69.9499 69.9499 5.611033730071356 45.757999999999996 45.757999999999996 2.5495442102462573 148.673 148.673 23.67817767481272 73.9175;65.9823 47.5608;43.9552 165.416;131.93 0 Linear,3(1) 1.8596470098962152 5.590849876403809 1.7232260704040527 2.020775556564331 0.14948179823857216 1.8468482494354248 41.472779034774675 79.54855429855866 30.934103502954525 50.709496497045464 61.32689411445482 179.1168392188785 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0016310 6 phosphorylation 244 262 8 8 4 7 4 4 92 258 2193 0.023709 0.9923 0.040009 1.53 24679;315994;24484;114494 prkar2b;mapkapk3;igfbp3;ccna2 PRKAR2B_33052;MAPKAPK3_9194;IGFBP3_8881;CCNA2_8221 79.177875 78.50975 50.946 31.577757072489582 81.20843768313101 31.02729976573099 48.04625 48.247749999999996 36.3081 12.971737658591971 49.03934961804102 12.92660581414405 189.3946 118.7559 85.0816 166.15670609694533 227.16943570531603 186.40501769095903 108.746;104.193;50.946;52.8265 59.3814;59.1667;36.3081;37.3288 147.467;434.985;85.0816;90.0448 1 3 1 24679 PRKAR2B_33052 108.746 108.746 59.3814 59.3814 147.467 147.467 108.746 59.3814 147.467 3 315994;24484;114494 MAPKAPK3_9194;IGFBP3_8881;CCNA2_8221 69.32183333333334 52.8265 30.213949900390915 44.26786666666666 37.3288 12.912857280375023 203.37046666666666 90.0448 200.5994201810497 104.193;50.946;52.8265 59.1667;36.3081;37.3288 434.985;85.0816;90.0448 0 Linear,3(0.75);Power,1(0.25) 1.7753377288513332 7.2007856369018555 1.5163835287094116 2.3255980014801025 0.36177688065678476 1.6794020533561707 48.23167306896019 110.12407693103981 35.33394709457986 60.75855290542014 26.56102802499356 352.2281719750064 DOWN 0.25 0.75 0.0 GO:0070482 4 response to oxygen levels 182 189 9 9 8 9 8 8 88 181 2270 0.71999 0.42049 0.69061 4.23 25664;54133;24484;63868;114494;65155;192272;170465 pparg;pdlim1;igfbp3;hspd1;ccna2;alas1;acot2;acaa2 PPARG_32510;PDLIM1_9452;IGFBP3_8881;HSPD1_8849;CCNA2_8221;ALAS1_8018;ACOT2_7969;ACAA2_7955 25664(0.0441) 48.0927875 51.886250000000004 13.6362 21.606400972492086 49.70226386460255 22.715641507112014 33.490987499999996 36.81845 11.3249 12.554936610915542 34.402488240956124 13.372093806737512 75.1228875 87.5632 16.9658 36.84982810886202 77.97525403264618 38.83337905796675 60.1903;67.1147;50.946;34.4455;52.8265;27.1843;13.6362;78.3988 43.9036;47.2419;36.3081;26.6907;37.3288;21.5215;11.3249;43.6084 101.057;123.914;85.0816;48.4857;90.0448;36.6615;16.9658;98.7727 5 3 5 25664;54133;63868;65155;192272 PPARG_32510;PDLIM1_9452;HSPD1_8849;ALAS1_8018;ACOT2_7969 40.5142 34.4455 22.537068072178336 30.136519999999997 26.6907 15.183015253631284 65.4168 48.4857 45.147466956020914 60.1903;67.1147;34.4455;27.1843;13.6362 43.9036;47.2419;26.6907;21.5215;11.3249 101.057;123.914;48.4857;36.6615;16.9658 3 24484;114494;170465 IGFBP3_8881;CCNA2_8221;ACAA2_7955 60.72376666666667 52.8265 15.335878604218678 39.08176666666667 37.3288 3.953259936221414 91.29969999999999 90.0448 6.931279485780461 50.946;52.8265;78.3988 36.3081;37.3288;43.6084 85.0816;90.0448;98.7727 0 Exp 2,3(0.38);Linear,4(0.5);Poly 2,1(0.13) 1.9811660933297388 16.92097580432892 1.5239794254302979 4.473705768585205 0.9830642898408765 1.7333461046218872 33.12031550820892 63.06525949179108 24.790860301353295 42.191114698646714 49.587259425491695 100.65851557450829 UP 0.625 0.375 0.0 GO:0042493 4 response to drug 436 472 27 27 20 26 19 19 77 453 1998 0.68369 0.41489 0.78863 4.03 286954;360243;78968;24950;83500;24679;25664;24614;24484;63868;24471;58868;25086;114494;25612;25649;65155;192272;114628 ugt2b1;top2a;srebf1;srd5a1;slc22a8;prkar2b;pparg;orm1;igfbp3;hspd1;hspb1;fzd1;cyp2e1;ccna2;asns;apoa2;alas1;acot2;abcg5 UGT2B10_33303,UGT2B1_33224;TOP2A_10059;SREBF1_32750;SRD5A1_32503;SLC22A8_9848;PRKAR2B_33052;PPARG_32510;ORM1_9400;IGFBP3_8881;HSPD1_8849;HSPB1_8847;FZD1_8671;CYP2E1_8421;CCNA2_8221;ASNS_8091;APOA2_33095;ALAS1_8018;ACOT2_7969;ABCG5_7947 25664(0.0441) 36.95960894736842 33.1119 3.54778 24.03631570051055 36.13372735942827 21.555196828407237 24.82198184210526 23.1774 1.51564 14.424422931773776 24.942324302673583 13.715823304839402 68.21430000000001 50.4329 8.55785 53.18802338815205 65.21193123458245 48.92283572965607 12.54415;54.9577;41.2009;29.2087;52.4905;108.746;60.1903;24.2519;50.946;34.4455;41.6322;25.231;7.89174;52.8265;28.1893;3.54778;27.1843;13.6362;33.1119 7.348245;18.8326;31.4864;22.9308;37.1479;59.3814;43.9036;19.7133;36.3081;26.6907;30.9494;13.6792;4.16797;37.3288;23.1774;1.51564;21.5215;11.3249;24.2098 25.495849999999997;218.525;60.0774;39.9852;89.1422;147.467;101.057;31.358;85.0816;48.4857;63.3196;131.659;15.8079;90.0448;35.9474;8.55785;36.6615;16.9658;50.4329 15 5 14 286954;78968;83500;24679;25664;24614;63868;24471;58868;25086;25612;25649;65155;192272 UGT2B10_33303,UGT2B1_33224;SREBF1_32750;SLC22A8_9848;PRKAR2B_33052;PPARG_32510;ORM1_9400;HSPD1_8849;HSPB1_8847;FZD1_8671;CYP2E1_8421;ASNS_8091;APOA2_33095;ALAS1_8018;ACOT2_7969 34.370126428571425 27.686799999999998 26.974823770187474 23.714825357142853 22.349449999999997 16.171710833626257 58.000157142857134 42.5736 43.84705904339038 12.54415;41.2009;52.4905;108.746;60.1903;24.2519;34.4455;41.6322;25.231;7.89174;28.1893;3.54778;27.1843;13.6362 7.348245;31.4864;37.1479;59.3814;43.9036;19.7133;26.6907;30.9494;13.6792;4.16797;23.1774;1.51564;21.5215;11.3249 25.495849999999997;60.0774;89.1422;147.467;101.057;31.358;48.4857;63.3196;131.659;15.8079;35.9474;8.55785;36.6615;16.9658 5 360243;24950;24484;114494;114628 TOP2A_10059;SRD5A1_32503;IGFBP3_8881;CCNA2_8221;ABCG5_7947 44.210159999999995 50.946 12.076191956821491 27.922020000000003 24.2098 8.368456519693458 96.81389999999999 85.0816 71.3753419361337 54.9577;29.2087;50.946;52.8265;33.1119 18.8326;22.9308;36.3081;37.3288;24.2098 218.525;39.9852;85.0816;90.0448;50.4329 0 Exp 2,7(0.35);Exp 4,2(0.1);Hill,1(0.05);Linear,7(0.35);Poly 2,2(0.1);Power,1(0.05) 1.9886994140816447 41.858686685562134 1.5124053955078125 4.473705768585205 0.7931217344894352 1.7720550894737244 26.15156329565324 47.76765459908359 18.335970279902874 31.307993404307652 44.298047939313676 92.13055206068631 UP 0.7368421052631579 0.2631578947368421 0.0 GO:0042127 5 regulation of cell population proliferation 436 466 8 8 6 8 6 6 90 460 1991 5.0557E-4 0.99986 0.0010539 1.29 308761;25664;24484;64515;25599;114494 prc1;pparg;igfbp3;cdc20;cd74;ccna2 PRC1_9556;PPARG_32510;IGFBP3_8881;CDC20_8255;CD74_8252;CCNA2_8221 25664(0.0441) 73.45768333333334 70.2454 50.946 21.9357255627815 74.80752700115113 21.24885040419143 46.363016666666674 47.08835 36.3081 8.786371130203072 47.56852964314793 8.740148430576435 174.5145666666667 109.91499999999999 85.0816 142.74663708226078 165.55735452733248 132.67662227291845 80.3005;60.1903;50.946;101.569;94.9138;52.8265 50.2731;43.9036;36.3081;51.5499;58.8146;37.3288 198.961;101.057;85.0816;453.17;118.773;90.0448 2 4 2 25664;25599 PPARG_32510;CD74_8252 77.55205 77.55205 24.55322231653108 51.3591 51.3591 10.543669214272617 109.91499999999999 109.91499999999999 12.527103735500948 60.1903;94.9138 43.9036;58.8146 101.057;118.773 4 308761;24484;64515;114494 PRC1_9556;IGFBP3_8881;CDC20_8255;CCNA2_8221 71.4105 66.5635 24.17111250025535 43.864975 43.80095 8.163946791993421 206.81435 144.5029 172.44010711249865 80.3005;50.946;101.569;52.8265 50.2731;36.3081;51.5499;37.3288 198.961;85.0816;453.17;90.0448 0 Exp 2,2(0.34);Linear,3(0.5);Poly 2,1(0.17) 1.743489689077125 10.573248028755188 1.5239794254302979 2.3255980014801025 0.29705624919441775 1.6978691816329956 55.90544730959691 91.00991935706976 39.33245551982521 53.393577813508124 60.293468372401705 288.7356649609316 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0042445 4 hormone metabolic process 53 64 7 7 5 7 5 5 91 59 2392 0.9685 0.090935 0.090935 7.81 360268;64305;24950;299270;499353 sult1e1;sult1b1;srd5a1;serpina6;cyp2c24 SULT1E1_32446;SULT1B1_32942;SRD5A1_32503;SERPINA6_32325;CYP2C24_32875 46.25454 58.9435 15.4629 22.68764608653793 47.642156822556316 23.511898724707464 32.210955999999996 36.9679 7.69418 16.84868550483034 32.4729197955574 17.590036876163527 67.31142 80.4167 35.0879 27.556612651721196 70.04215786037558 27.533192902684416 2.5 59.1082 59.2729;15.4629;29.2087;68.3847;58.9435 45.3114;7.69418;22.9308;36.9679;48.1505 91.5578;35.0879;39.9852;89.5095;80.4167 4 1 4 360268;64305;299270;499353 SULT1E1_32446;SULT1B1_32942;SERPINA6_32325;CYP2C24_32875 50.516000000000005 59.1082 23.77475070433614 34.530995 41.13965 18.510008047290714 74.142975 84.9631 26.483106118099123 59.2729;15.4629;68.3847;58.9435 45.3114;7.69418;36.9679;48.1505 91.5578;35.0879;89.5095;80.4167 1 24950 SRD5A1_32503 29.2087 29.2087 22.9308 22.9308 39.9852 39.9852 29.2087 22.9308 39.9852 0 Exp 2,2(0.4);Exp 4,1(0.2);Linear,1(0.2);Poly 2,1(0.2) 2.158898996973088 11.08116900920868 1.619360327720642 2.9455835819244385 0.5720456546077197 1.9512832164764404 26.3679413916093 66.14113860839072 17.442432000836135 46.97947999916387 43.15698402539931 91.46585597460069 UP 0.8 0.2 0.0 GO:0002791 7 regulation of peptide secretion 138 149 9 9 8 9 8 8 88 141 2310 0.89486 0.19604 0.26762 5.37 78968;25664;24614;63868;25427;65210;25599;25649 srebf1;pparg;orm1;hspd1;cyp51;cyp2j4;cd74;apoa2 SREBF1_32750;PPARG_32510;ORM1_9400;HSPD1_8849;CYP51_8429;CYP2J4_32580;CD74_8252;APOA2_33095 25664(0.0441) 43.752235 37.8232 3.54778 30.975183239989764 41.74384619708674 30.394677243154867 29.807505 29.088549999999998 1.51564 19.837776363398188 28.688928857559553 19.710444971632768 72.06626875 54.281549999999996 8.55785 54.13738270539746 63.68805119015467 43.08598887520313 6.5 85.03299999999999 41.2009;60.1903;24.2519;34.4455;75.1522;16.3155;94.9138;3.54778 31.4864;43.9036;19.7133;26.6907;48.098;8.2378;58.8146;1.51564 60.0774;101.057;31.358;48.4857;171.379;36.8422;118.773;8.55785 7 1 7 78968;25664;24614;63868;65210;25599;25649 SREBF1_32750;PPARG_32510;ORM1_9400;HSPD1_8849;CYP2J4_32580;CD74_8252;APOA2_33095 39.26652571428571 34.4455 30.52164510825001 27.19457714285714 26.6907 19.884783319823324 57.87873571428572 48.4857 39.25126791906126 41.2009;60.1903;24.2519;34.4455;16.3155;94.9138;3.54778 31.4864;43.9036;19.7133;26.6907;8.2378;58.8146;1.51564 60.0774;101.057;31.358;48.4857;36.8422;118.773;8.55785 1 25427 CYP51_8429 75.1522 75.1522 48.098 48.098 171.379 171.379 75.1522 48.098 171.379 0 Exp 2,4(0.5);Exp 4,1(0.13);Hill,1(0.13);Linear,1(0.13);Poly 2,1(0.13) 1.8813503843449466 15.63535487651825 1.5239794254302979 3.5849626064300537 0.6738037771196363 1.6919933557510376 22.2875281248572 65.2169418751428 16.060627333583355 43.55438266641665 34.55097653185568 109.5815609681443 UP 0.875 0.125 0.0 GO:0008217 4 regulation of blood pressure 48 54 3 3 3 3 3 3 93 51 2400 0.85614 0.33302 0.45585 5.56 25664;65030;81633 pparg;ephx2;acta2 PPARG_32510;EPHX2_33282;ACTA2_33040 25664(0.0441) 52.32918333333333 60.1903 6.44145 42.5059101821833 50.115714585247886 40.40334678858698 38.94499 43.9036 2.66377 34.073601475574904 36.998074679081014 32.254226493607 73.99143333333333 101.057 17.3473 49.07134778119848 73.97821011366385 48.82093377189793 1.5 75.27305 60.1903;6.44145;90.3558 43.9036;2.66377;70.2676 101.057;17.3473;103.57 2 1 2 25664;65030 PPARG_32510;EPHX2_33282 33.315875 33.315875 38.006176315978564 23.283685 23.283685 29.160963447980414 59.20215 59.20215 59.19169652109154 60.1903;6.44145 43.9036;2.66377 101.057;17.3473 1 81633 ACTA2_33040 90.3558 90.3558 70.2676 70.2676 103.57 103.57 90.3558 70.2676 103.57 0 Exp 2,1(0.34);Exp 4,1(0.34);Poly 2,1(0.34) 1.7957518688349112 5.498547434806824 1.5239794254302979 2.3739430904388428 0.4701655307590519 1.600624918937683 4.229217909099518 100.42914875756715 0.38708015100092297 77.50289984899908 18.461975865426872 129.5208908012398 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0002931 4 response to ischemia 27 28 2 2 2 2 2 2 94 26 2425 0.91386 0.28498 0.28498 7.14 63868;24471 hspd1;hspb1 HSPD1_8849;HSPB1_8847 38.03885 38.03885 34.4455 5.081764304353405 38.12632138415068 5.08025845394791 28.820050000000002 28.820050000000002 26.6907 3.0113556490391393 28.871883857498226 3.010463311092491 55.90265 55.90265 48.4857 10.48915128144312 56.08319764570008 10.486043090711767 0.5 38.03885 34.4455;41.6322 26.6907;30.9494 48.4857;63.3196 2 0 2 63868;24471 HSPD1_8849;HSPB1_8847 38.03885 38.03885 5.081764304353405 28.820050000000002 28.820050000000002 3.0113556490391393 55.90265 55.90265 10.48915128144312 34.4455;41.6322 26.6907;30.9494 48.4857;63.3196 0 0 Exp 2,1(0.5);Linear,1(0.5) 1.7487009299051195 3.5026177167892456 1.6557694673538208 1.8468482494354248 0.13511310255076875 1.7513088583946228 30.995884000000004 45.08181599999999 24.646524 32.993576000000004 41.365428 70.43987200000001 UP 1.0 0.0 0.0 GO:0051336 5 regulation of hydrolase activity 294 317 11 11 8 11 8 8 88 309 2142 0.13643 0.92614 0.2692 2.52 361604;84386;299270;25664;24484;63868;25649;502970 sytl2;slpi;serpina6;pparg;igfbp3;hspd1;apoa2;angptl3 SYTL2_32351;SLPI_9890;SERPINA6_32325;PPARG_32510;IGFBP3_8881;HSPD1_8849;APOA2_33095;ANGPTL3_8045 25664(0.0441) 49.5424225 55.9079 3.54778 21.411972022747154 52.06454171055713 19.931849503597626 33.4647675 37.393550000000005 1.51564 14.035782943539843 34.897967564329925 12.968200738099695 83.27408125 91.02625 8.55785 38.688759245455444 87.29039491634599 35.79752481608802 67.0093;53.7429;68.3847;60.1903;50.946;34.4455;3.54778;58.0729 44.4373;37.8192;36.9679;43.9036;36.3081;26.6907;1.51564;40.0757 135.846;92.543;89.5095;101.057;85.0816;48.4857;8.55785;105.112 5 3 5 299270;25664;63868;25649;502970 SERPINA6_32325;PPARG_32510;HSPD1_8849;APOA2_33095;ANGPTL3_8045 44.928236000000005 58.0729 26.354071722458357 29.830707999999998 36.9679 17.070064338288823 70.54441 89.5095 41.27508744122176 68.3847;60.1903;34.4455;3.54778;58.0729 36.9679;43.9036;26.6907;1.51564;40.0757 89.5095;101.057;48.4857;8.55785;105.112 3 361604;84386;24484 SYTL2_32351;SLPI_9890;IGFBP3_8881 57.23273333333333 53.7429 8.58146865305315 39.52153333333334 37.8192 4.32370526786146 104.4902 92.543 27.409993938707895 67.0093;53.7429;50.946 44.4373;37.8192;36.3081 135.846;92.543;85.0816 0 Exp 2,2(0.25);Hill,1(0.13);Linear,4(0.5);Poly 2,1(0.13) 1.6554010256618816 13.276893258094788 1.512166976928711 1.8690931797027588 0.12675637924818875 1.684902310371399 34.70468289645606 64.38016210354392 23.73846614733328 43.19106885266672 56.46413891220785 110.08402358779216 UP 0.625 0.375 0.0 GO:0009992 6 cellular water homeostasis 1 1 1 1 1 1 1 1 95 0 2451 1.0 0.037691 0.037691 100.0 155423 anxa7 ANXA7_8051 64.7676 64.7676 64.7676 64.7676 43.3787 43.3787 43.3787 43.3787 127.439 127.439 127.439 127.439 0.0 64.7676 0.0 64.7676 64.7676 43.3787 127.439 1 0 1 155423 ANXA7_8051 64.7676 64.7676 43.3787 43.3787 127.439 127.439 64.7676 43.3787 127.439 0 0 Linear,1(1) 1.5738487243652344 1.5738487243652344 1.5738487243652344 1.5738487243652344 0.0 1.5738487243652344 64.7676 64.7676 43.3787 43.3787 127.439 127.439 UP 1.0 0.0 0.0 GO:0042737 5 drug catabolic process 55 60 10 10 10 10 10 10 86 50 2401 0.99999 5.7005E-5 5.7005E-5 16.67 360268;64305;114027;65210;25086;24303;499353;171521;29277;24894 sult1e1;sult1b1;dao;cyp2j4;cyp2e1;cyp2d3;cyp2c24;cyp2c13;cyp2c11;cyp2a1 SULT1E1_32446;SULT1B1_32942;DAO_8437;CYP2J4_32580;CYP2E1_8421;CYP2D3_8420;CYP2C24_32875;CYP2C13_8419;CYP2C11_32593;CYP2A1_32717 34.525891 15.889199999999999 6.1336 33.057079460593094 39.07624860900112 33.412395970461205 22.302137999999996 8.5521 2.43617 21.103588670322193 25.326039739510833 20.916027516428972 50.083659999999995 35.96505 15.8079 35.09578770467413 55.7414301159939 34.4599667015064 2.0 9.37187 5.0 16.3155 59.2729;15.4629;6.1336;16.3155;7.89174;12.8059;58.9435;104.635;54.426;9.37187 45.3114;7.69418;2.43617;8.2378;4.16797;8.8664;48.1505;49.2461;43.9518;4.95906 91.5578;35.0879;16.2027;36.8422;15.8079;22.6004;80.4167;108.327;74.8861;19.1079 10 0 10 360268;64305;114027;65210;25086;24303;499353;171521;29277;24894 SULT1E1_32446;SULT1B1_32942;DAO_8437;CYP2J4_32580;CYP2E1_8421;CYP2D3_8420;CYP2C24_32875;CYP2C13_8419;CYP2C11_32593;CYP2A1_32717 34.525891 15.889199999999999 33.057079460593094 22.302137999999996 8.5521 21.103588670322193 50.083659999999995 35.96505 35.09578770467413 59.2729;15.4629;6.1336;16.3155;7.89174;12.8059;58.9435;104.635;54.426;9.37187 45.3114;7.69418;2.43617;8.2378;4.16797;8.8664;48.1505;49.2461;43.9518;4.95906 91.5578;35.0879;16.2027;36.8422;15.8079;22.6004;80.4167;108.327;74.8861;19.1079 0 0 Exp 2,3(0.3);Exp 4,4(0.4);Hill,1(0.1);Poly 2,1(0.1);Power,1(0.1) 2.104618229802127 21.718549728393555 1.5310101509094238 2.9455835819244385 0.5754193254608209 2.0016056895256042 14.03690087782568 55.01488112217432 9.221998227697698 35.38227777230231 28.33106541679741 71.8362545832026 UP 1.0 0.0 0.0 GO:0002544 6 chronic inflammatory response 13 14 2 2 2 2 2 2 94 12 2439 0.98604 0.095353 0.095353 14.29 29142;24614 vnn1;orm1 VNN1_10157;ORM1_9400 22.492350000000002 22.492350000000002 20.7328 2.4883794736735494 23.447921267146942 2.089449571491644 18.27145 18.27145 16.8296 2.039083824907608 19.054485680450014 1.7121837200734509 29.0709 29.0709 26.7838 3.2344478385034594 30.312971578012434 2.7159103833130556 0.0 20.7328 0.5 22.492350000000002 20.7328;24.2519 16.8296;19.7133 26.7838;31.358 2 0 2 29142;24614 VNN1_10157;ORM1_9400 22.492350000000002 22.492350000000002 2.4883794736735494 18.27145 18.27145 2.039083824907608 29.0709 29.0709 3.2344478385034594 20.7328;24.2519 16.8296;19.7133 26.7838;31.358 0 0 Exp 2,1(0.5);Linear,1(0.5) 4.064642751673144 8.19346833229065 3.5849626064300537 4.608505725860596 0.7237542805861685 4.096734166145325 19.043632000000002 25.941068 15.445424000000001 21.097476 24.588184000000002 33.553616000000005 UP 1.0 0.0 0.0 GO:0045940 7 positive regulation of steroid metabolic process 23 25 4 4 2 4 2 2 94 23 2428 0.93448 0.24238 0.24238 8.0 78968;25649 srebf1;apoa2 SREBF1_32750;APOA2_33095 22.37434 22.37434 3.54778 26.624776484830814 25.98146897120999 26.131512853972207 16.50102 16.50102 1.51564 21.19252763331453 19.372187029058452 20.799904501494602 34.317625 34.317625 8.55785 36.42982316867939 39.25314326219717 35.75490644748335 0.5 22.37434 41.2009;3.54778 31.4864;1.51564 60.0774;8.55785 2 0 2 78968;25649 SREBF1_32750;APOA2_33095 22.37434 22.37434 26.624776484830814 16.50102 16.50102 21.19252763331453 34.317625 34.317625 36.42982316867939 41.2009;3.54778 31.4864;1.51564 60.0774;8.55785 0 0 Exp 2,1(0.5);Hill,1(0.5) 1.817017753464136 3.6388078927993774 1.7262524366378784 1.912555456161499 0.1317361284606819 1.8194039463996887 -14.52571759999999 59.274397599999986 -12.870324799999995 45.8723648 -16.171533999999987 84.806784 UP 1.0 0.0 0.0 GO:0050865 5 regulation of cell activation 163 173 7 7 6 7 6 6 90 167 2284 0.519 0.64589 1.0 3.47 29142;309607;25664;63868;25599;81633 vnn1;rt1-ce5;pparg;hspd1;cd74;acta2 VNN1_10157;RT1-CE5_32445;PPARG_32510;HSPD1_8849;CD74_8252;ACTA2_33040 25664(0.0441) 59.24313333333333 57.505449999999996 20.7328 29.52564582092434 65.04916272369414 26.594979113712327 40.51605 35.29715 16.8296 20.869042474224837 43.80799000251262 18.87281467568382 91.08225 102.3135 26.7838 45.14554266049971 100.55181148831626 38.3478146633021 20.7328;54.8206;60.1903;34.4455;94.9138;90.3558 16.8296;26.5902;43.9036;26.6907;58.8146;70.2676 26.7838;147.824;101.057;48.4857;118.773;103.57 4 2 4 29142;25664;63868;25599 VNN1_10157;PPARG_32510;HSPD1_8849;CD74_8252 52.5706 47.3179 32.62499641471245 36.559625 35.29715 18.582137015670906 73.77487500000001 74.77135 43.269885986551486 20.7328;60.1903;34.4455;94.9138 16.8296;43.9036;26.6907;58.8146 26.7838;101.057;48.4857;118.773 2 309607;81633 RT1-CE5_32445;ACTA2_33040 72.5882 72.5882 25.127180890820195 48.4289 48.4289 30.884585724597326 125.697 125.697 31.29230349462951 54.8206;90.3558 26.5902;70.2676 147.824;103.57 0 Exp 2,3(0.5);Linear,1(0.17);Poly 2,2(0.34) 1.9618069546700017 12.89415454864502 1.5239794254302979 4.608505725860596 1.2096305566977998 1.6567518711090088 35.61769624811497 82.8685704185517 23.817338209108733 57.21476179089127 54.95829239810368 127.20620760189632 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0045787 6 positive regulation of cell cycle 111 119 4 4 2 4 2 2 94 117 2334 0.16326 0.94548 0.32177 1.68 64515;25612 cdc20;asns CDC20_8255;ASNS_8091 64.87915 64.87915 28.1893 51.8872834714345 73.40075179570027 50.46835435910344 37.36365 37.36365 23.1774 20.062387149215308 40.658555088852985 19.513753586532307 244.55870000000002 244.55870000000002 35.9474 295.02092972428244 293.01085853112966 286.9531767427023 101.569;28.1893 51.5499;23.1774 453.17;35.9474 1 1 1 25612 ASNS_8091 28.1893 28.1893 23.1774 23.1774 35.9474 35.9474 28.1893 23.1774 35.9474 1 64515 CDC20_8255 101.569 101.569 51.5499 51.5499 453.17 453.17 101.569 51.5499 453.17 0 Exp 2,2(1) 2.2331918006842035 4.790316939353943 1.5293418169021606 3.2609751224517822 1.2244496528826143 2.3951584696769714 -7.032955999999984 136.791256 9.558599999999998 65.1687 -164.31944799999994 653.4368479999999 CONFLICT 0.5 0.5 0.0 GO:0070328 8 triglyceride homeostasis 18 18 3 3 2 3 2 2 94 16 2435 0.97193 0.14569 0.14569 11.11 502970;114628 angptl3;abcg5 ANGPTL3_8045;ABCG5_7947 45.5924 45.5924 33.1119 17.65009236519743 46.66356425517921 17.58496445196446 32.14275 32.14275 24.2098 11.21888547962763 32.82361154225584 11.177488381812513 77.77244999999999 77.77244999999999 50.4329 38.663962399177365 80.11892239394936 38.52129440989576 0.0 33.1119 0.5 45.5924 58.0729;33.1119 40.0757;24.2098 105.112;50.4329 1 1 1 502970 ANGPTL3_8045 58.0729 58.0729 40.0757 40.0757 105.112 105.112 58.0729 40.0757 105.112 1 114628 ABCG5_7947 33.1119 33.1119 24.2098 24.2098 50.4329 50.4329 33.1119 24.2098 50.4329 0 Exp 2,1(0.5);Linear,1(0.5) 1.973108248127511 4.069574236869812 1.5375925302505493 2.5319817066192627 0.703139329748823 2.034787118434906 21.130619999999997 70.05418 16.594168000000003 47.691331999999996 24.18693199999999 131.357968 CONFLICT 0.5 0.5 0.0 GO:0010951 8 negative regulation of endopeptidase activity 84 91 3 3 2 3 2 2 94 89 2362 0.32387 0.86644 0.58104 2.2 84386;299270 slpi;serpina6 SLPI_9890;SERPINA6_32325 61.0638 61.0638 53.7429 10.353316068777128 61.03582203821656 10.35324046312596 37.393550000000005 37.393550000000005 36.9679 0.6019600028236561 37.39517668789809 0.6019556069788169 91.02625 91.02625 89.5095 2.1450084207298956 91.0320464968153 2.144992756688423 53.7429;68.3847 37.8192;36.9679 92.543;89.5095 1 1 1 299270 SERPINA6_32325 68.3847 68.3847 36.9679 36.9679 89.5095 89.5095 68.3847 36.9679 89.5095 1 84386 SLPI_9890 53.7429 53.7429 37.8192 37.8192 92.543 92.543 53.7429 37.8192 92.543 0 Linear,1(0.5);Poly 2,1(0.5) 1.7898858664647055 3.583128333091736 1.714035153388977 1.8690931797027588 0.1096425818838772 1.791564166545868 46.714836000000005 75.412764 36.559276000000004 38.227824000000005 88.05342 93.99908 CONFLICT 0.5 0.5 0.0 GO:0042221 3 response to chemical 909 981 47 45 35 45 32 32 64 949 1502 0.1695 0.87979 0.33605 3.26 286954;360243;78968;24950;84386;83500;24679;25664;24614;291234;24552;315994;25626;24484;63868;24471;58868;65030;25315;65210;25086;25413;114494;25612;25649;155423;502970;65155;192272;170465;114628;140668 ugt2b1;top2a;srebf1;srd5a1;slpi;slc22a8;prkar2b;pparg;orm1;mki67;me1;mapkapk3;krt8;igfbp3;hspd1;hspb1;fzd1;ephx2;ephx1;cyp2j4;cyp2e1;cpt2;ccna2;asns;apoa2;anxa7;angptl3;alas1;acot2;acaa2;abcg5;abcc3 UGT2B10_33303,UGT2B1_33224;TOP2A_10059;SREBF1_32750;SRD5A1_32503;SLPI_9890;SLC22A8_9848;PRKAR2B_33052;PPARG_32510;ORM1_9400;MKI67_9232;ME1_9215;MAPKAPK3_9194;KRT8_8978;IGFBP3_8881;HSPD1_8849;HSPB1_8847;FZD1_8671;EPHX2_33282;EPHX1_8567;CYP2J4_32580;CYP2E1_8421;CPT2_8374;CCNA2_8221;ASNS_8091;APOA2_33095;ANXA7_8051;ANGPTL3_8045;ALAS1_8018;ACOT2_7969;ACAA2_7955;ABCG5_7947;ABCC3_7941 25664(0.0441) 42.2575975 37.9892 3.54778 25.390244361652226 42.505041940932344 24.735805905436138 28.14496328125 26.67345 1.51564 15.125457011736204 28.508699893196077 15.084843871526564 82.99875937500002 61.698499999999996 8.55785 79.48830549830993 83.92754614514143 81.80970416576254 12.54415;54.9577;41.2009;29.2087;53.7429;52.4905;108.746;60.1903;24.2519;49.7822;49.3339;104.193;68.9539;50.946;34.4455;41.6322;25.231;6.44145;34.0134;16.3155;7.89174;31.2175;52.8265;28.1893;3.54778;64.7676;58.0729;27.1843;13.6362;78.3988;33.1119;34.7775 7.348245;18.8326;31.4864;22.9308;37.8192;37.1479;59.3814;43.9036;19.7133;35.6665;35.4173;59.1667;45.3374;36.3081;26.6907;30.9494;13.6792;2.66377;26.1579;8.2378;4.16797;24.8356;37.3288;23.1774;1.51564;43.3787;40.0757;21.5215;11.3249;43.6084;24.2098;26.6562 25.495849999999997;218.525;60.0774;39.9852;92.543;89.1422;147.467;101.057;31.358;82.1147;80.9924;434.985;143.578;85.0816;48.4857;63.3196;131.659;17.3473;48.3681;36.8422;15.8079;42.0237;90.0448;35.9474;8.55785;127.439;105.112;36.6615;16.9658;98.7727;50.4329;49.7705 24 9 23 286954;78968;83500;24679;25664;24614;24552;25626;63868;24471;58868;65030;25315;65210;25086;25413;25612;25649;155423;502970;65155;192272;140668 UGT2B10_33303,UGT2B1_33224;SREBF1_32750;SLC22A8_9848;PRKAR2B_33052;PPARG_32510;ORM1_9400;ME1_9215;KRT8_8978;HSPD1_8849;HSPB1_8847;FZD1_8671;EPHX2_33282;EPHX1_8567;CYP2J4_32580;CYP2E1_8421;CPT2_8374;ASNS_8091;APOA2_33095;ANXA7_8051;ANGPTL3_8045;ALAS1_8018;ACOT2_7969;ABCC3_7941 36.74240956521739 34.0134 24.635422898479938 25.424692391304344 26.1579 15.506542134424624 63.62936521739132 48.4857 43.52328006592205 12.54415;41.2009;52.4905;108.746;60.1903;24.2519;49.3339;68.9539;34.4455;41.6322;25.231;6.44145;34.0134;16.3155;7.89174;31.2175;28.1893;3.54778;64.7676;58.0729;27.1843;13.6362;34.7775 7.348245;31.4864;37.1479;59.3814;43.9036;19.7133;35.4173;45.3374;26.6907;30.9494;13.6792;2.66377;26.1579;8.2378;4.16797;24.8356;23.1774;1.51564;43.3787;40.0757;21.5215;11.3249;26.6562 25.495849999999997;60.0774;89.1422;147.467;101.057;31.358;80.9924;143.578;48.4857;63.3196;131.659;17.3473;48.3681;36.8422;15.8079;42.0237;35.9474;8.55785;127.439;105.112;36.6615;16.9658;49.7705 9 360243;24950;84386;291234;315994;24484;114494;170465;114628 TOP2A_10059;SRD5A1_32503;SLPI_9890;MKI67_9232;MAPKAPK3_9194;IGFBP3_8881;CCNA2_8221;ACAA2_7955;ABCG5_7947 56.35196666666666 52.8265 22.7630495203301 35.09676666666667 36.3081 12.232411039631558 132.4983222222222 90.0448 124.25537849631277 54.9577;29.2087;53.7429;49.7822;104.193;50.946;52.8265;78.3988;33.1119 18.8326;22.9308;37.8192;35.6665;59.1667;36.3081;37.3288;43.6084;24.2098 218.525;39.9852;92.543;82.1147;434.985;85.0816;90.0448;98.7727;50.4329 0 Exp 2,8(0.25);Exp 4,4(0.13);Hill,1(0.04);Linear,16(0.49);Poly 2,3(0.1);Power,1(0.04) 1.9223257950781976 65.81248772144318 1.5124053955078125 4.473705768585205 0.6458724031325745 1.8061060905456543 33.460326657587196 51.05486834241284 22.904259802693296 33.385666759806696 55.457466651987374 110.54005209801261 UP 0.71875 0.28125 0.0 GO:0007062 5 sister chromatid cohesion 12 13 2 2 2 2 2 2 94 11 2440 0.98873 0.083726 0.083726 15.38 293502;64515 kif22;cdc20 KIF22_8963;CDC20_8255 87.74325 87.74325 73.9175 19.552563159979794 85.96249534352489 19.389702211015894 49.555350000000004 49.555350000000004 47.5608 2.820719660831061 49.29845224037955 2.797224783102857 309.293 309.293 165.416 203.47280471355384 290.7616626251977 201.77800010953254 0.0 73.9175 0.5 87.74325 73.9175;101.569 47.5608;51.5499 165.416;453.17 0 2 0 2 293502;64515 KIF22_8963;CDC20_8255 87.74325 87.74325 19.552563159979794 49.555350000000004 49.555350000000004 2.820719660831061 309.293 309.293 203.47280471355384 73.9175;101.569 47.5608;51.5499 165.416;453.17 0 Exp 2,1(0.5);Linear,1(0.5) 1.757969442631916 3.5501173734664917 1.5293418169021606 2.020775556564331 0.3474961298189851 1.7750586867332458 60.644780000000004 114.84172000000001 45.646032000000005 53.464668 27.294080000000008 591.29192 DOWN 0.0 1.0 0.0 GO:0051716 3 cellular response to stimulus 785 838 27 27 19 27 19 19 77 819 1632 0.0027814 0.99872 0.0053622 2.27 286954;360243;78968;24950;25664;24614;338475;291234;316273;293502;24484;63868;24471;58868;25315;114494;25612;65155;170465 ugt2b1;top2a;srebf1;srd5a1;pparg;orm1;nrep;mki67;mcm3;kif22;igfbp3;hspd1;hspb1;fzd1;ephx1;ccna2;asns;alas1;acaa2 UGT2B10_33303,UGT2B1_33224;TOP2A_10059;SREBF1_32750;SRD5A1_32503;PPARG_32510;ORM1_9400;NREP_9364;MKI67_9232;MCM3_9207;KIF22_8963;IGFBP3_8881;HSPD1_8849;HSPB1_8847;FZD1_8671;EPHX1_8567;CCNA2_8221;ASNS_8091;ALAS1_8018;ACAA2_7955 25664(0.0441) 44.33343421052632 41.6322 12.54415 18.335619741442933 46.227252969784956 18.674078544608534 29.645760263157896 30.9494 7.348245 11.057416066976208 30.835636815896926 11.116926685351844 85.89823947368421 82.1147 25.495849999999997 52.66714753492651 87.89010400871064 50.80117561686255 12.54415;54.9577;41.2009;29.2087;60.1903;24.2519;69.4104;49.7822;54.0045;73.9175;50.946;34.4455;41.6322;25.231;34.0134;52.8265;28.1893;27.1843;78.3988 7.348245;18.8326;31.4864;22.9308;43.9036;19.7133;43.1468;35.6665;33.259;47.5608;36.3081;26.6907;30.9494;13.6792;26.1579;37.3288;23.1774;21.5215;43.6084 25.495849999999997;218.525;60.0774;39.9852;101.057;31.358;157.944;82.1147;111.753;165.416;85.0816;48.4857;63.3196;131.659;48.3681;90.0448;35.9474;36.6615;98.7727 11 9 10 286954;78968;25664;24614;63868;24471;58868;25315;25612;65155 UGT2B10_33303,UGT2B1_33224;SREBF1_32750;PPARG_32510;ORM1_9400;HSPD1_8849;HSPB1_8847;FZD1_8671;EPHX1_8567;ASNS_8091;ALAS1_8018 32.888295 31.101349999999996 12.894302515677436 24.462764500000002 24.667650000000002 10.106344621492983 58.24295500000001 48.4269 33.6696980086319 12.54415;41.2009;60.1903;24.2519;34.4455;41.6322;25.231;34.0134;28.1893;27.1843 7.348245;31.4864;43.9036;19.7133;26.6907;30.9494;13.6792;26.1579;23.1774;21.5215 25.495849999999997;60.0774;101.057;31.358;48.4857;63.3196;131.659;48.3681;35.9474;36.6615 9 360243;24950;338475;291234;316273;293502;24484;114494;170465 TOP2A_10059;SRD5A1_32503;NREP_9364;MKI67_9232;MCM3_9207;KIF22_8963;IGFBP3_8881;CCNA2_8221;ACAA2_7955 57.05025555555556 54.0045 14.957321641850772 35.40464444444444 36.3081 9.450099953189797 116.62633333333332 98.7727 54.290866279490345 54.9577;29.2087;69.4104;49.7822;54.0045;73.9175;50.946;52.8265;78.3988 18.8326;22.9308;43.1468;35.6665;33.259;47.5608;36.3081;37.3288;43.6084 218.525;39.9852;157.944;82.1147;111.753;165.416;85.0816;90.0448;98.7727 0 Exp 2,8(0.4);Exp 4,1(0.05);Linear,8(0.4);Poly 2,3(0.15) 1.9578700534195455 40.23096680641174 1.5124053955078125 3.5849626064300537 0.5369582691061117 1.8430557250976562 36.08873407897512 52.57813434207752 24.67373962859162 34.61778089772417 62.216201760599375 109.58027718676908 CONFLICT 0.5263157894736842 0.47368421052631576 0.0 GO:0033559 7 unsaturated fatty acid metabolic process 42 53 13 13 12 13 12 12 84 41 2410 1.0 3.0624E-7 3.0624E-7 22.64 65030;25315;50549;65210;25086;24303;499353;171521;29277;24894;25599;50681 ephx2;ephx1;cyp4a1;cyp2j4;cyp2e1;cyp2d3;cyp2c24;cyp2c13;cyp2c11;cyp2a1;cd74;acox1 EPHX2_33282;EPHX1_8567;CYP4A1_33111;CYP2J4_32580;CYP2E1_8421;CYP2D3_8420;CYP2C24_32875;CYP2C13_8419;CYP2C11_32593;CYP2A1_32717;CD74_8252;ACOX1_7973 37.23063 23.5047 6.44145 33.90363387272575 42.244874950853536 36.81533088566897 24.431516666666667 18.98115 2.66377 20.387484825420064 26.906879904129323 21.97369443330727 50.318016666666665 34.09825 15.8079 36.35612245575536 56.608004599752675 38.4856361318586 1.5 8.631805 4.5 19.76175 6.44145;34.0134;23.208;16.3155;7.89174;12.8059;58.9435;104.635;54.426;9.37187;94.9138;23.8014 2.66377;26.1579;18.863;8.2378;4.16797;8.8664;48.1505;49.2461;43.9518;4.95906;58.8146;19.0993 17.3473;48.3681;29.9853;36.8422;15.8079;22.6004;80.4167;108.327;74.8861;19.1079;118.773;31.3543 12 0 12 65030;25315;50549;65210;25086;24303;499353;171521;29277;24894;25599;50681 EPHX2_33282;EPHX1_8567;CYP4A1_33111;CYP2J4_32580;CYP2E1_8421;CYP2D3_8420;CYP2C24_32875;CYP2C13_8419;CYP2C11_32593;CYP2A1_32717;CD74_8252;ACOX1_7973 37.23063 23.5047 33.90363387272575 24.431516666666667 18.98115 20.387484825420064 50.318016666666665 34.09825 36.35612245575536 6.44145;34.0134;23.208;16.3155;7.89174;12.8059;58.9435;104.635;54.426;9.37187;94.9138;23.8014 2.66377;26.1579;18.863;8.2378;4.16797;8.8664;48.1505;49.2461;43.9518;4.95906;58.8146;19.0993 17.3473;48.3681;29.9853;36.8422;15.8079;22.6004;80.4167;108.327;74.8861;19.1079;118.773;31.3543 0 0 Exp 2,3(0.25);Exp 4,4(0.34);Linear,2(0.17);Poly 2,2(0.17);Power,1(0.09) 2.0113460502211433 24.738684058189392 1.5310101509094238 2.9415390491485596 0.4887530875674963 1.970352590084076 18.047843299933778 56.413416700066236 12.896211211652092 35.96682212168123 29.747603921875747 70.8884294114576 UP 1.0 0.0 0.0 GO:0050707 6 regulation of cytokine secretion 61 67 5 5 4 5 4 4 92 63 2388 0.89437 0.24433 0.31796 5.97 24614;63868;65210;25649 orm1;hspd1;cyp2j4;apoa2 ORM1_9400;HSPD1_8849;CYP2J4_32580;APOA2_33095 19.640169999999998 20.2837 3.54778 13.04459398272966 19.298896535399788 11.922119184867368 14.03936 13.97555 1.51564 11.29530374375711 13.540820895385698 10.556983452386298 31.3109375 34.1001 8.55785 16.765764098671188 31.583388547023592 15.343673079085416 2.5 29.3487 24.2519;34.4455;16.3155;3.54778 19.7133;26.6907;8.2378;1.51564 31.358;48.4857;36.8422;8.55785 4 0 4 24614;63868;65210;25649 ORM1_9400;HSPD1_8849;CYP2J4_32580;APOA2_33095 19.640169999999998 20.2837 13.04459398272966 14.03936 13.97555 11.29530374375711 31.3109375 34.1001 16.765764098671188 24.2519;34.4455;16.3155;3.54778 19.7133;26.6907;8.2378;1.51564 31.358;48.4857;36.8422;8.55785 0 0 Exp 2,2(0.5);Exp 4,1(0.25);Hill,1(0.25) 2.111661815515975 8.907462239265442 1.6557694673538208 3.5849626064300537 0.9134567721343948 1.8333650827407837 6.85646789692494 32.42387210307506 2.9699623311180368 25.108757668881964 14.88048868330224 47.74138631669776 UP 1.0 0.0 0.0 GO:0006725 4 cellular aromatic compound metabolic process 429 482 31 30 28 31 27 27 69 455 1996 0.99123 0.016454 0.023621 5.6 286954;360243;360268;64305;78968;24950;298490;313245;680308;291234;316273;293502;63868;364975;65030;25315;114027;25086;24894;362485;65155;24763;681337;314304;192272;50559;170465 ugt2b1;top2a;sult1e1;sult1b1;srebf1;srd5a1;ppcs;polr1e;mthfd2;mki67;mcm3;kif22;hspd1;gcdh;ephx2;ephx1;dao;cyp2e1;cyp2a1;ccne2;alas1;acsm3;acot4;acot3;acot2;acot1;acaa2 UGT2B10_33303,UGT2B1_33224;TOP2A_10059;SULT1E1_32446;SULT1B1_32942;SREBF1_32750;SRD5A1_32503;PPCS_9540;POLR1E_9523;MTHFD2_9261;MKI67_9232;MCM3_9207;KIF22_8963;HSPD1_8849;GCDH_8693;EPHX2_33282;EPHX1_8567;DAO_8437;CYP2E1_8421;CYP2A1_32717;CCNE2_8227;ALAS1_8018;ACSM3_7976;ACOT4_7971;ACOT3_7970;ACOT2_7969;ACOT1_7968;ACAA2_7955 36.00325222222222 30.8838 6.1336 23.976714217702543 35.969507110260025 23.829271432649886 24.20835388888889 24.6874 2.43617 16.253236362741745 23.877594176436553 16.074773449515686 67.0686388888889 41.2585 15.8079 56.921647414771854 65.90977013744974 53.212039692064835 23.5 73.94975 12.54415;54.9577;59.2729;15.4629;41.2009;29.2087;15.1091;73.982;57.4184;49.7822;54.0045;73.9175;34.4455;15.9021;6.44145;34.0134;6.1336;7.89174;9.37187;77.8893;27.1843;52.2057;12.3157;30.8838;13.6362;28.5134;78.3988 7.348245;18.8326;45.3114;7.69418;31.4864;22.9308;7.94061;47.589;46.387;35.6665;33.259;47.5608;26.6907;10.4227;2.66377;26.1579;2.43617;4.16797;4.95906;49.2672;21.5215;42.2655;6.70485;24.6874;11.3249;24.741;43.6084 25.495849999999997;218.525;91.5578;35.0879;60.0774;39.9852;30.6311;165.722;79.7903;82.1147;111.753;165.416;48.4857;31.2818;17.3473;48.3681;16.2027;15.8079;19.1079;185.461;36.6615;71.1126;24.3993;41.2585;16.9658;33.4642;98.7727 21 7 20 286954;360268;64305;78968;298490;313245;680308;63868;364975;65030;25315;114027;25086;24894;65155;24763;681337;314304;192272;50559 UGT2B10_33303,UGT2B1_33224;SULT1E1_32446;SULT1B1_32942;SREBF1_32750;PPCS_9540;POLR1E_9523;MTHFD2_9261;HSPD1_8849;GCDH_8693;EPHX2_33282;EPHX1_8567;DAO_8437;CYP2E1_8421;CYP2A1_32717;ALAS1_8018;ACSM3_7976;ACOT4_7971;ACOT3_7970;ACOT2_7969;ACOT1_7968 27.696455499999995 21.5432 20.07648663653172 20.12501275 16.4232 15.797248300791056 45.44128250000001 34.27605 35.76042468796327 12.54415;59.2729;15.4629;41.2009;15.1091;73.982;57.4184;34.4455;15.9021;6.44145;34.0134;6.1336;7.89174;9.37187;27.1843;52.2057;12.3157;30.8838;13.6362;28.5134 7.348245;45.3114;7.69418;31.4864;7.94061;47.589;46.387;26.6907;10.4227;2.66377;26.1579;2.43617;4.16797;4.95906;21.5215;42.2655;6.70485;24.6874;11.3249;24.741 25.495849999999997;91.5578;35.0879;60.0774;30.6311;165.722;79.7903;48.4857;31.2818;17.3473;48.3681;16.2027;15.8079;19.1079;36.6615;71.1126;24.3993;41.2585;16.9658;33.4642 7 360243;24950;291234;316273;293502;362485;170465 TOP2A_10059;SRD5A1_32503;MKI67_9232;MCM3_9207;KIF22_8963;CCNE2_8227;ACAA2_7955 59.73695714285714 54.9577 18.09987920510862 35.87504285714286 35.6665 11.836363867880072 128.8610857142857 111.753 63.06289819321738 54.9577;29.2087;49.7822;54.0045;73.9175;77.8893;78.3988 18.8326;22.9308;35.6665;33.259;47.5608;49.2672;43.6084 218.525;39.9852;82.1147;111.753;165.416;185.461;98.7727 0 Exp 2,9(0.33);Exp 4,5(0.18);Hill,3(0.11);Linear,8(0.29);Poly 2,3(0.11) 2.2079007828433865 105.81966960430145 1.5184675455093384 50.888092041015625 9.25306231323302 1.8705788850784302 26.95918344907834 45.04732099536611 18.07759776792427 30.33911000985351 45.597669629900395 88.53960814787743 UP 0.7407407407407407 0.25925925925925924 0.0 GO:0097267 7 omega-hydroxylase P450 pathway 2 2 1 1 1 1 1 1 95 1 2450 0.99859 0.073976 0.073976 50.0 50549 cyp4a1 CYP4A1_33111 23.208 23.208 23.208 23.208 18.863 18.863 18.863 18.863 29.9853 29.9853 29.9853 29.985299999999995 0.0 23.208 0.0 23.208 23.208 18.863 29.9853 1 0 1 50549 CYP4A1_33111 23.208 23.208 18.863 18.863 29.9853 29.9853 23.208 18.863 29.9853 0 0 Exp 2,1(1) 2.0425233840942383 2.0425233840942383 2.0425233840942383 2.0425233840942383 0.0 2.0425233840942383 23.208 23.208 18.863 18.863 29.9853 29.9853 UP 1.0 0.0 0.0