Gene Ontology Analyses GO Category: BP GO File Creation Date: 07/15/20 Deduplicate Gene Sets: true Data Source: Liver_PFHxSAm_Male Work Source: Liver_PFHxSAm_Male_williams_0.05_NOMTC_foldfilter1.5_BMD BMDExpress2 Version: BMDExpress 2.30.0507 BETA Timestamp (Start Time): 02/12/2021 22:59.40 Remove Promiscuous Probes: true Remove BMD > Highest Dose from Category Descriptive Statistics: true Remove BMD with p-Value < Cutoff: 0.1 Remove genes with BMDU/BMDL >: 40.0 Identify conflicting probe sets: 0.5 Category Count: 4133 Total Run Time: 1 seconds GO/Pathway/Gene Set/Gene ID GO Level GO/Pathway/Gene Set/Gene Name All Genes (Expression Data) All Genes (Platform) Input Genes Genes with BMD <= Highest Dose Genes with BMD p-Value >= Genes with BMDU/BMDL <= Genes That Passed All Filters Fisher's A Parameter Fisher's B Parameter Fisher's C Parameter Fisher's D Parameter Fisher's Exact Left P-Value Fisher's Exact Right P-Value Fisher's Exact Two Tail Percentage Entrez Gene IDs Gene Symbols Probe IDs Genes with Conflicting Probesets BMD Mean BMD Median BMD Minimum BMD Standard Deviation BMD wMean BMD wSD BMDL Mean BMDL Median BMDL Minimum BMDL Standard Deviation BMDL wMean BMDL wSD BMDU Mean BMDU Median BMDU Minimum BMDU Standard Deviation BMDU wMean BMDU wSD 5th Percentile Index BMD at 5th Percentile of Total Genes 10th Percentile Index BMD at 10th Percentile of Total Genes BMD List BMDL List BMDU List Probes with Adverse Direction Up Probes with Adverse Direction Down Genes with Adverse Direction Up Genes Up List Genes Up Probes List Genes Up BMD Mean Genes Up BMD Median Genes Up SD Genes Up BMDL Mean Genes Up BMDL Median Genes Up BMDL SD Genes Up BMDU Mean Genes Up BMDU Median Genes Up BMDU SD BMD list (up) BMDL List (up) BMDU List (up) Genes with Adverse Direction Down Genes Down List Genes Down Probes List Genes Down BMD Mean Genes Down BMD Median Genes Down SD Genes Down BMDL Mean Genes Down BMDL Median Genes Down BMDL SD Genes Down BMDU Mean Genes Down BMDU Median Genes Down BMDU SD BMD list (down) BMDL List (down) BMDU List (down) Genes with Adverse Conflict Count Genes Conflict List Genes Conflict Probes List BMD list (Conflict) BMDL list (Conflict) BMDU list (Conflict) Model Counts Mean Fold Change Total Fold Change Min Fold Change Max Fold Change Standard Deviation Fold Change Median Fold Change Lower bound of the 95% confidence interval - BMD Upper bound of the 95% confidence interval - BMD Lower bound of the 95% confidence interval - BMDL Upper bound of the 95% confidence interval - BMDL Lower bound of the 95% confidence interval - BMDU Upper bound of the 95% confidence interval - BMDU Overall Direction Percent Genes With Overall Direction Up Percent Genes With Overall Direction Down Percent Genes With Overall Direction Conflict GO:0000028 8 ribosomal small subunit assembly 2 7 1 1 1 0 0 0 162 7 2378 0.63092 1.0 1.0 0.0 0 0 0 0 0 GO:0000056 9 ribosomal small subunit export from nucleus 3 4 1 1 0 1 0 0 162 4 2381 0.76872 1.0 1.0 0.0 0 0 0 0 0 GO:0000255 5 allantoin metabolic process 1 1 1 1 0 1 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0000266 7 mitochondrial fission 8 8 1 1 0 1 0 0 162 8 2377 0.59068 1.0 1.0 0.0 0 0 0 0 0 GO:0000320 4 re-entry into mitotic cell cycle 4 4 2 2 1 1 0 0 162 4 2381 0.76872 1.0 1.0 0.0 0 0 0 0 0 GO:0000963 8 mitochondrial RNA processing 4 4 1 1 0 1 0 0 162 4 2381 0.76872 1.0 1.0 0.0 0 0 0 0 0 GO:0000964 9 mitochondrial RNA 5'-end processing 1 1 1 1 0 1 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0000965 9 mitochondrial RNA 3'-end processing 2 2 1 1 0 1 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:0000966 8 RNA 5'-end processing 3 3 2 1 0 2 0 0 162 3 2382 0.821 1.0 1.0 0.0 0 0 0 0 0 GO:0001188 9 RNA polymerase I preinitiation complex assembly 3 3 1 1 0 1 0 0 162 3 2382 0.821 1.0 1.0 0.0 0 0 0 0 0 GO:0001510 7 RNA methylation 6 8 1 1 0 1 0 0 162 8 2377 0.59068 1.0 1.0 0.0 0 0 0 0 0 GO:0001541 5 ovarian follicle development 20 20 1 1 1 0 0 0 162 20 2365 0.26729 1.0 0.63398 0.0 0 0 0 0 0 GO:0001649 5 osteoblast differentiation 27 27 1 1 0 0 0 0 162 27 2358 0.168 1.0 0.41224 0.0 0 0 0 0 0 GO:0001657 6 ureteric bud development 12 13 1 1 0 1 0 0 162 13 2372 0.42468 1.0 1.0 0.0 0 0 0 0 0 GO:0001682 11 tRNA 5'-leader removal 2 2 1 0 0 1 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:0001759 6 organ induction 7 7 1 1 0 1 0 0 162 7 2378 0.63092 1.0 1.0 0.0 0 0 0 0 0 GO:0001783 8 B cell apoptotic process 5 6 1 1 1 0 0 0 162 6 2379 0.67388 1.0 1.0 0.0 0 0 0 0 0 GO:0001894 6 tissue homeostasis 38 39 1 1 1 0 0 0 162 39 2346 0.075552 1.0 0.17351 0.0 0 0 0 0 0 GO:0001919 5 regulation of receptor recycling 8 8 1 1 0 1 0 0 162 8 2377 0.59068 1.0 1.0 0.0 0 0 0 0 0 GO:0001921 6 positive regulation of receptor recycling 7 7 1 1 0 1 0 0 162 7 2378 0.63092 1.0 1.0 0.0 0 0 0 0 0 GO:0001935 5 endothelial cell proliferation 7 8 1 1 0 1 0 0 162 8 2377 0.59068 1.0 1.0 0.0 0 0 0 0 0 GO:0001941 6 postsynaptic membrane organization 2 2 1 1 0 1 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:0001959 6 regulation of cytokine-mediated signaling pathway 30 30 2 2 0 2 0 0 162 30 2355 0.13763 1.0 0.25683 0.0 0 0 0 0 0 GO:0001960 7 negative regulation of cytokine-mediated signaling pathway 13 13 2 2 0 2 0 0 162 13 2372 0.42468 1.0 1.0 0.0 0 0 0 0 0 GO:0001976 5 nervous system process involved in regulation of systemic arterial blood pressure 2 3 1 1 0 1 0 0 162 3 2382 0.821 1.0 1.0 0.0 0 0 0 0 0 GO:0001990 6 regulation of systemic arterial blood pressure by hormone 7 10 1 1 0 1 0 0 162 10 2375 0.51769 1.0 1.0 0.0 0 0 0 0 0 GO:0001991 8 regulation of systemic arterial blood pressure by circulatory renin-angiotensin 1 1 1 1 0 1 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0002001 6 renin secretion into blood stream 1 1 1 1 0 1 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0002016 8 regulation of blood volume by renin-angiotensin 2 3 1 1 0 1 0 0 162 3 2382 0.821 1.0 1.0 0.0 0 0 0 0 0 GO:0002018 9 renin-angiotensin regulation of aldosterone production 1 1 1 1 0 1 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0002019 9 regulation of renal output by angiotensin 2 2 1 1 0 1 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:0002035 9 brain renin-angiotensin system 1 2 1 1 0 1 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:0002053 7 positive regulation of mesenchymal cell proliferation 10 10 1 1 1 0 0 0 162 10 2375 0.51769 1.0 1.0 0.0 0 0 0 0 0 GO:0002066 6 columnar/cuboidal epithelial cell development 9 9 1 1 0 0 0 0 162 9 2376 0.55299 1.0 1.0 0.0 0 0 0 0 0 GO:0002068 7 glandular epithelial cell development 5 5 1 1 0 0 0 0 162 5 2380 0.71975 1.0 1.0 0.0 0 0 0 0 0 GO:0002072 6 optic cup morphogenesis involved in camera-type eye development 1 1 1 1 0 1 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0002082 6 regulation of oxidative phosphorylation 7 8 1 1 1 0 0 0 162 8 2377 0.59068 1.0 1.0 0.0 0 0 0 0 0 GO:0002138 7 retinoic acid biosynthetic process 3 3 1 1 0 1 0 0 162 3 2382 0.821 1.0 1.0 0.0 0 0 0 0 0 GO:0002246 6 wound healing involved in inflammatory response 2 2 1 1 1 0 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:0002260 6 lymphocyte homeostasis 22 24 1 1 1 0 0 0 162 24 2361 0.20503 1.0 0.39808 0.0 0 0 0 0 0 GO:0002275 5 myeloid cell activation involved in immune response 15 15 1 0 0 0 0 0 162 15 2370 0.37211 1.0 0.61863 0.0 0 0 0 0 0 GO:0002278 6 eosinophil activation involved in immune response 2 2 1 0 0 0 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:0002283 6 neutrophil activation involved in immune response 6 6 1 0 0 0 0 0 162 6 2379 0.67388 1.0 1.0 0.0 0 0 0 0 0 GO:0002323 6 natural killer cell activation involved in immune response 4 4 1 0 0 0 0 0 162 4 2381 0.76872 1.0 1.0 0.0 0 0 0 0 0 GO:0002429 7 immune response-activating cell surface receptor signaling pathway 37 40 1 1 0 1 0 0 162 40 2345 0.070672 1.0 0.17717 0.0 0 0 0 0 0 GO:0002437 4 inflammatory response to antigenic stimulus 15 19 1 1 0 1 0 0 162 19 2366 0.28559 1.0 0.62863 0.0 0 0 0 0 0 GO:0002438 5 acute inflammatory response to antigenic stimulus 7 9 1 1 0 1 0 0 162 9 2376 0.55299 1.0 1.0 0.0 0 0 0 0 0 GO:0002439 5 chronic inflammatory response to antigenic stimulus 2 3 1 1 0 1 0 0 162 3 2382 0.821 1.0 1.0 0.0 0 0 0 0 0 GO:0002544 6 chronic inflammatory response 13 14 2 2 0 2 0 0 162 14 2371 0.39753 1.0 1.0 0.0 0 0 0 0 0 GO:0002701 7 negative regulation of production of molecular mediator of immune response 11 12 3 3 1 2 0 0 162 12 2373 0.45368 1.0 1.0 0.0 0 0 0 0 0 GO:0002704 7 negative regulation of leukocyte mediated immunity 17 18 1 1 1 0 0 0 162 18 2367 0.30513 1.0 0.62425 0.0 0 0 0 0 0 GO:0002719 7 negative regulation of cytokine production involved in immune response 11 12 3 3 1 2 0 0 162 12 2373 0.45368 1.0 1.0 0.0 0 0 0 0 0 GO:0002739 7 regulation of cytokine secretion involved in immune response 6 7 2 2 0 2 0 0 162 7 2378 0.63092 1.0 1.0 0.0 0 0 0 0 0 GO:0002740 7 negative regulation of cytokine secretion involved in immune response 3 4 2 2 0 2 0 0 162 4 2381 0.76872 1.0 1.0 0.0 0 0 0 0 0 GO:0002757 6 immune response-activating signal transduction 38 41 1 1 0 1 0 0 162 41 2344 0.066105 1.0 0.10857 0.0 0 0 0 0 0 GO:0002764 5 immune response-regulating signaling pathway 45 49 1 1 0 1 0 0 162 49 2336 0.0387 1.0 0.071716 0.0 0 0 0 0 0 GO:0002768 6 immune response-regulating cell surface receptor signaling pathway 43 47 1 1 0 1 0 0 162 47 2338 0.04425 1.0 0.07113 0.0 0 0 0 0 0 GO:0002886 7 regulation of myeloid leukocyte mediated immunity 26 28 2 1 1 0 0 0 162 28 2357 0.1572 1.0 0.25527 0.0 0 0 0 0 0 GO:0002887 8 negative regulation of myeloid leukocyte mediated immunity 2 2 1 1 1 0 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:0002902 10 regulation of B cell apoptotic process 8 10 1 1 1 0 0 0 162 10 2375 0.51769 1.0 1.0 0.0 0 0 0 0 0 GO:0002904 11 positive regulation of B cell apoptotic process 3 3 1 1 1 0 0 0 162 3 2382 0.821 1.0 1.0 0.0 0 0 0 0 0 GO:0002933 6 lipid hydroxylation 3 3 2 2 0 2 0 0 162 3 2382 0.821 1.0 1.0 0.0 0 0 0 0 0 GO:0003014 4 renal system process 24 25 1 1 0 1 0 0 162 25 2360 0.19186 1.0 0.40169 0.0 0 0 0 0 0 GO:0003044 6 regulation of systemic arterial blood pressure mediated by a chemical signal 9 12 1 1 0 1 0 0 162 12 2373 0.45368 1.0 1.0 0.0 0 0 0 0 0 GO:0003071 5 renal system process involved in regulation of systemic arterial blood pressure 6 7 1 1 0 1 0 0 162 7 2378 0.63092 1.0 1.0 0.0 0 0 0 0 0 GO:0003073 5 regulation of systemic arterial blood pressure 15 18 2 2 0 2 0 0 162 18 2367 0.30513 1.0 0.62425 0.0 0 0 0 0 0 GO:0003081 7 regulation of systemic arterial blood pressure by renin-angiotensin 3 5 1 1 0 1 0 0 162 5 2380 0.71975 1.0 1.0 0.0 0 0 0 0 0 GO:0003156 7 regulation of animal organ formation 10 10 1 1 0 1 0 0 162 10 2375 0.51769 1.0 1.0 0.0 0 0 0 0 0 GO:0003158 6 endothelium development 5 5 1 1 1 0 0 0 162 5 2380 0.71975 1.0 1.0 0.0 0 0 0 0 0 GO:0003323 8 type B pancreatic cell development 4 4 1 1 0 0 0 0 162 4 2381 0.76872 1.0 1.0 0.0 0 0 0 0 0 GO:0006002 5 fructose 6-phosphate metabolic process 8 8 1 1 1 0 0 0 162 8 2377 0.59068 1.0 1.0 0.0 0 0 0 0 0 GO:0006003 5 fructose 2,6-bisphosphate metabolic process 2 2 1 1 1 0 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:0006013 6 mannose metabolic process 5 5 1 1 1 0 0 0 162 5 2380 0.71975 1.0 1.0 0.0 0 0 0 0 0 GO:0006026 6 aminoglycan catabolic process 3 3 1 1 0 0 0 0 162 3 2382 0.821 1.0 1.0 0.0 0 0 0 0 0 GO:0006027 7 glycosaminoglycan catabolic process 3 3 1 1 0 0 0 0 162 3 2382 0.821 1.0 1.0 0.0 0 0 0 0 0 GO:0006071 6 glycerol metabolic process 6 6 1 1 0 1 0 0 162 6 2379 0.67388 1.0 1.0 0.0 0 0 0 0 0 GO:0006072 6 glycerol-3-phosphate metabolic process 1 1 1 1 0 1 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0006083 6 acetate metabolic process 2 2 1 1 1 0 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:0006099 4 tricarboxylic acid cycle 6 6 2 2 0 2 0 0 162 6 2379 0.67388 1.0 1.0 0.0 0 0 0 0 0 GO:0006101 6 citrate metabolic process 3 3 1 1 0 1 0 0 162 3 2382 0.821 1.0 1.0 0.0 0 0 0 0 0 GO:0006102 7 isocitrate metabolic process 3 3 1 1 0 1 0 0 162 3 2382 0.821 1.0 1.0 0.0 0 0 0 0 0 GO:0006103 8 2-oxoglutarate metabolic process 6 6 1 1 0 1 0 0 162 6 2379 0.67388 1.0 1.0 0.0 0 0 0 0 0 GO:0006104 8 succinyl-CoA metabolic process 1 1 1 1 0 1 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0006107 8 oxaloacetate metabolic process 6 6 1 1 0 1 0 0 162 6 2379 0.67388 1.0 1.0 0.0 0 0 0 0 0 GO:0006114 7 glycerol biosynthetic process 3 3 1 1 0 1 0 0 162 3 2382 0.821 1.0 1.0 0.0 0 0 0 0 0 GO:0006116 4 NADH oxidation 3 3 1 1 0 1 0 0 162 3 2382 0.821 1.0 1.0 0.0 0 0 0 0 0 GO:0006127 5 glycerophosphate shuttle 1 1 1 1 0 1 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0006338 6 chromatin remodeling 22 24 1 1 1 0 0 0 162 24 2361 0.20503 1.0 0.39808 0.0 0 0 0 0 0 GO:0006352 7 DNA-templated transcription, initiation 6 6 1 1 1 0 0 0 162 6 2379 0.67388 1.0 1.0 0.0 0 0 0 0 0 GO:0006354 7 DNA-templated transcription, elongation 2 2 1 1 0 1 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:0006360 8 transcription by RNA polymerase I 3 4 1 1 0 1 0 0 162 4 2381 0.76872 1.0 1.0 0.0 0 0 0 0 0 GO:0006362 8 transcription elongation from RNA polymerase I promoter 1 1 1 1 0 1 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0006400 8 tRNA modification 4 5 1 1 0 1 0 0 162 5 2380 0.71975 1.0 1.0 0.0 0 0 0 0 0 GO:0006404 7 RNA import into nucleus 1 1 1 1 0 1 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0006528 6 asparagine metabolic process 2 2 1 1 0 1 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:0006529 7 asparagine biosynthetic process 1 1 1 1 0 1 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0006544 8 glycine metabolic process 3 3 1 1 0 1 0 0 162 3 2382 0.821 1.0 1.0 0.0 0 0 0 0 0 GO:0006642 8 triglyceride mobilization 2 2 1 1 0 1 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:0006722 7 triterpenoid metabolic process 1 1 1 1 1 0 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0006734 3 NADH metabolic process 6 8 2 2 0 2 0 0 162 8 2377 0.59068 1.0 1.0 0.0 0 0 0 0 0 GO:0006760 5 folic acid-containing compound metabolic process 6 7 1 1 0 1 0 0 162 7 2378 0.63092 1.0 1.0 0.0 0 0 0 0 0 GO:0006778 5 porphyrin-containing compound metabolic process 14 15 2 2 1 1 0 0 162 15 2370 0.37211 1.0 0.61863 0.0 0 0 0 0 0 GO:0006779 6 porphyrin-containing compound biosynthetic process 8 8 1 1 0 1 0 0 162 8 2377 0.59068 1.0 1.0 0.0 0 0 0 0 0 GO:0006782 7 protoporphyrinogen IX biosynthetic process 4 4 1 1 0 1 0 0 162 4 2381 0.76872 1.0 1.0 0.0 0 0 0 0 0 GO:0006783 6 heme biosynthetic process 7 7 1 1 0 1 0 0 162 7 2378 0.63092 1.0 1.0 0.0 0 0 0 0 0 GO:0006787 6 porphyrin-containing compound catabolic process 2 3 1 1 1 0 0 0 162 3 2382 0.821 1.0 1.0 0.0 0 0 0 0 0 GO:0006788 6 heme oxidation 1 1 1 1 1 0 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0006842 8 tricarboxylic acid transport 2 2 1 0 0 1 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:0006883 9 cellular sodium ion homeostasis 4 4 1 1 0 0 0 0 162 4 2381 0.76872 1.0 1.0 0.0 0 0 0 0 0 GO:0006885 9 regulation of pH 14 15 1 1 0 1 0 0 162 15 2370 0.37211 1.0 0.61863 0.0 0 0 0 0 0 GO:0006887 5 exocytosis 32 34 1 0 0 0 0 0 162 34 2351 0.10545 1.0 0.16633 0.0 0 0 0 0 0 GO:0006892 6 post-Golgi vesicle-mediated transport 6 6 1 0 0 0 0 0 162 6 2379 0.67388 1.0 1.0 0.0 0 0 0 0 0 GO:0006893 6 Golgi to plasma membrane transport 3 3 1 0 0 0 0 0 162 3 2382 0.821 1.0 1.0 0.0 0 0 0 0 0 GO:0006904 6 vesicle docking involved in exocytosis 8 8 1 0 0 0 0 0 162 8 2377 0.59068 1.0 1.0 0.0 0 0 0 0 0 GO:0006906 7 vesicle fusion 6 6 1 0 0 0 0 0 162 6 2379 0.67388 1.0 1.0 0.0 0 0 0 0 0 GO:0006924 9 activation-induced cell death of T cells 3 4 1 1 0 1 0 0 162 4 2381 0.76872 1.0 1.0 0.0 0 0 0 0 0 GO:0006939 6 smooth muscle contraction 7 7 2 2 1 1 0 0 162 7 2378 0.63092 1.0 1.0 0.0 0 0 0 0 0 GO:0006972 5 hyperosmotic response 8 8 1 1 1 0 0 0 162 8 2377 0.59068 1.0 1.0 0.0 0 0 0 0 0 GO:0007171 10 activation of transmembrane receptor protein tyrosine kinase activity 1 1 1 1 1 0 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0007229 6 integrin-mediated signaling pathway 28 29 1 1 0 1 0 0 162 29 2356 0.14709 1.0 0.25549 0.0 0 0 0 0 0 GO:0007259 7 receptor signaling pathway via JAK-STAT 9 9 1 1 1 0 0 0 162 9 2376 0.55299 1.0 1.0 0.0 0 0 0 0 0 GO:0007266 8 Rho protein signal transduction 11 12 1 1 0 1 0 0 162 12 2373 0.45368 1.0 1.0 0.0 0 0 0 0 0 GO:0007281 4 germ cell development 25 25 1 1 0 1 0 0 162 25 2360 0.19186 1.0 0.40169 0.0 0 0 0 0 0 GO:0007286 5 spermatid development 12 12 1 1 0 1 0 0 162 12 2373 0.45368 1.0 1.0 0.0 0 0 0 0 0 GO:0007411 5 axon guidance 40 45 1 1 0 1 0 0 162 45 2340 0.05059 1.0 0.11311 0.0 0 0 0 0 0 GO:0007528 7 neuromuscular junction development 8 9 1 1 0 1 0 0 162 9 2376 0.55299 1.0 1.0 0.0 0 0 0 0 0 GO:0007548 4 sex differentiation 7 7 1 1 1 0 0 0 162 7 2378 0.63092 1.0 1.0 0.0 0 0 0 0 0 GO:0007586 3 digestion 1 1 1 1 1 0 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0008033 9 tRNA processing 8 9 2 1 0 2 0 0 162 9 2376 0.55299 1.0 1.0 0.0 0 0 0 0 0 GO:0008277 6 regulation of G protein-coupled receptor signaling pathway 29 29 1 1 0 1 0 0 162 29 2356 0.14709 1.0 0.25549 0.0 0 0 0 0 0 GO:0009116 6 nucleoside metabolic process 13 17 1 1 0 1 0 0 162 17 2368 0.32601 1.0 0.62101 0.0 0 0 0 0 0 GO:0009119 7 ribonucleoside metabolic process 9 12 1 1 0 1 0 0 162 12 2373 0.45368 1.0 1.0 0.0 0 0 0 0 0 GO:0009240 6 isopentenyl diphosphate biosynthetic process 2 2 2 2 0 1 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:0009268 4 response to pH 14 16 1 1 0 1 0 0 162 16 2369 0.3483 1.0 0.61907 0.0 0 0 0 0 0 GO:0009303 9 rRNA transcription 4 5 1 1 0 1 0 0 162 5 2380 0.71975 1.0 1.0 0.0 0 0 0 0 0 GO:0009395 6 phospholipid catabolic process 8 9 1 1 0 1 0 0 162 9 2376 0.55299 1.0 1.0 0.0 0 0 0 0 0 GO:0009405 3 pathogenesis 1 1 1 1 1 0 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0009415 4 response to water 12 12 1 1 1 0 0 0 162 12 2373 0.45368 1.0 1.0 0.0 0 0 0 0 0 GO:0009451 7 RNA modification 10 13 1 1 0 1 0 0 162 13 2372 0.42468 1.0 1.0 0.0 0 0 0 0 0 GO:0009581 4 detection of external stimulus 25 26 1 1 1 0 0 0 162 26 2359 0.17954 1.0 0.40644 0.0 0 0 0 0 0 GO:0009582 4 detection of abiotic stimulus 25 26 1 1 1 0 0 0 162 26 2359 0.17954 1.0 0.40644 0.0 0 0 0 0 0 GO:0009593 4 detection of chemical stimulus 18 18 2 2 1 1 0 0 162 18 2367 0.30513 1.0 0.62425 0.0 0 0 0 0 0 GO:0009730 5 detection of carbohydrate stimulus 2 2 1 1 1 0 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:0009732 7 detection of hexose stimulus 2 2 1 1 1 0 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:0010045 6 response to nickel cation 1 2 1 1 0 1 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:0010359 7 regulation of anion channel activity 2 2 1 1 1 0 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:0010383 6 cell wall polysaccharide metabolic process 1 1 1 1 1 0 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0010447 5 response to acidic pH 8 9 1 1 0 1 0 0 162 9 2376 0.55299 1.0 1.0 0.0 0 0 0 0 0 GO:0010464 6 regulation of mesenchymal cell proliferation 11 11 1 1 1 0 0 0 162 11 2374 0.48464 1.0 1.0 0.0 0 0 0 0 0 GO:0010470 6 regulation of gastrulation 12 12 1 1 0 1 0 0 162 12 2373 0.45368 1.0 1.0 0.0 0 0 0 0 0 GO:0010631 6 epithelial cell migration 28 30 1 1 0 1 0 0 162 30 2355 0.13763 1.0 0.25683 0.0 0 0 0 0 0 GO:0010749 7 regulation of nitric oxide mediated signal transduction 4 4 1 1 0 1 0 0 162 4 2381 0.76872 1.0 1.0 0.0 0 0 0 0 0 GO:0010751 8 negative regulation of nitric oxide mediated signal transduction 1 1 1 1 0 1 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0010762 7 regulation of fibroblast migration 9 10 1 1 1 0 0 0 162 10 2375 0.51769 1.0 1.0 0.0 0 0 0 0 0 GO:0010763 8 positive regulation of fibroblast migration 7 8 1 1 1 0 0 0 162 8 2377 0.59068 1.0 1.0 0.0 0 0 0 0 0 GO:0010771 8 negative regulation of cell morphogenesis involved in differentiation 19 20 1 1 0 0 0 0 162 20 2365 0.26729 1.0 0.63398 0.0 0 0 0 0 0 GO:0010803 7 regulation of tumor necrosis factor-mediated signaling pathway 11 11 1 1 0 1 0 0 162 11 2374 0.48464 1.0 1.0 0.0 0 0 0 0 0 GO:0010804 8 negative regulation of tumor necrosis factor-mediated signaling pathway 4 4 1 1 0 1 0 0 162 4 2381 0.76872 1.0 1.0 0.0 0 0 0 0 0 GO:0010872 6 regulation of cholesterol esterification 4 4 3 3 0 3 0 0 162 4 2381 0.76872 1.0 1.0 0.0 0 0 0 0 0 GO:0010873 7 positive regulation of cholesterol esterification 4 4 3 3 0 3 0 0 162 4 2381 0.76872 1.0 1.0 0.0 0 0 0 0 0 GO:0010896 7 regulation of triglyceride catabolic process 9 11 1 1 0 1 0 0 162 11 2374 0.48464 1.0 1.0 0.0 0 0 0 0 0 GO:0010898 8 positive regulation of triglyceride catabolic process 5 7 1 1 0 1 0 0 162 7 2378 0.63092 1.0 1.0 0.0 0 0 0 0 0 GO:0010901 5 regulation of very-low-density lipoprotein particle remodeling 3 3 2 2 0 2 0 0 162 3 2382 0.821 1.0 1.0 0.0 0 0 0 0 0 GO:0010903 6 negative regulation of very-low-density lipoprotein particle remodeling 3 3 2 2 0 2 0 0 162 3 2382 0.821 1.0 1.0 0.0 0 0 0 0 0 GO:0010918 6 positive regulation of mitochondrial membrane potential 7 7 1 1 1 0 0 0 162 7 2378 0.63092 1.0 1.0 0.0 0 0 0 0 0 GO:0010949 8 negative regulation of intestinal phytosterol absorption 2 2 1 1 0 1 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:0010971 9 positive regulation of G2/M transition of mitotic cell cycle 10 10 1 1 0 1 0 0 162 10 2375 0.51769 1.0 1.0 0.0 0 0 0 0 0 GO:0010977 8 negative regulation of neuron projection development 36 38 1 1 0 0 0 0 162 38 2347 0.080767 1.0 0.17055 0.0 0 0 0 0 0 GO:0014003 6 oligodendrocyte development 7 7 1 1 0 1 0 0 162 7 2378 0.63092 1.0 1.0 0.0 0 0 0 0 0 GO:0014012 8 peripheral nervous system axon regeneration 7 7 1 1 0 1 0 0 162 7 2378 0.63092 1.0 1.0 0.0 0 0 0 0 0 GO:0014060 7 regulation of epinephrine secretion 2 2 1 1 1 0 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:0014821 7 phasic smooth muscle contraction 3 3 1 1 0 1 0 0 162 3 2382 0.821 1.0 1.0 0.0 0 0 0 0 0 GO:0014829 9 vascular smooth muscle contraction 2 2 1 1 1 0 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:0015695 6 organic cation transport 6 7 1 1 1 0 0 0 162 7 2378 0.63092 1.0 1.0 0.0 0 0 0 0 0 GO:0015727 7 lactate transport 2 2 1 1 1 0 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:0015744 7 succinate transport 2 2 1 0 0 1 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:0015746 9 citrate transport 2 2 1 0 0 1 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:0015939 5 pantothenate metabolic process 1 1 1 1 0 1 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0016032 4 viral process 22 23 1 1 1 0 0 0 162 23 2362 0.21909 1.0 0.39574 0.0 0 0 0 0 0 GO:0016050 6 vesicle organization 36 39 1 0 0 0 0 0 162 39 2346 0.075552 1.0 0.17351 0.0 0 0 0 0 0 GO:0016055 7 Wnt signaling pathway 31 35 2 2 1 1 0 0 162 35 2350 0.098656 1.0 0.16618 0.0 0 0 0 0 0 GO:0016079 5 synaptic vesicle exocytosis 8 8 1 0 0 0 0 0 162 8 2377 0.59068 1.0 1.0 0.0 0 0 0 0 0 GO:0016081 7 synaptic vesicle docking 3 3 1 0 0 0 0 0 162 3 2382 0.821 1.0 1.0 0.0 0 0 0 0 0 GO:0016098 7 monoterpenoid metabolic process 2 3 1 1 0 1 0 0 162 3 2382 0.821 1.0 1.0 0.0 0 0 0 0 0 GO:0016102 7 diterpenoid biosynthetic process 3 3 1 1 0 1 0 0 162 3 2382 0.821 1.0 1.0 0.0 0 0 0 0 0 GO:0016104 7 triterpenoid biosynthetic process 1 1 1 1 1 0 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0016239 9 positive regulation of macroautophagy 19 21 1 1 1 0 0 0 162 21 2364 0.25015 1.0 0.64016 0.0 0 0 0 0 0 GO:0016241 8 regulation of macroautophagy 26 28 1 1 1 0 0 0 162 28 2357 0.1572 1.0 0.25527 0.0 0 0 0 0 0 GO:0016242 9 negative regulation of macroautophagy 7 7 1 1 1 0 0 0 162 7 2378 0.63092 1.0 1.0 0.0 0 0 0 0 0 GO:0016331 5 morphogenesis of embryonic epithelium 6 6 1 1 0 1 0 0 162 6 2379 0.67388 1.0 1.0 0.0 0 0 0 0 0 GO:0016557 6 peroxisome membrane biogenesis 1 1 1 1 0 1 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0017000 5 antibiotic biosynthetic process 9 9 1 1 1 0 0 0 162 9 2376 0.55299 1.0 1.0 0.0 0 0 0 0 0 GO:0017156 7 calcium-ion regulated exocytosis 6 7 1 0 0 0 0 0 162 7 2378 0.63092 1.0 1.0 0.0 0 0 0 0 0 GO:0018158 6 protein oxidation 8 8 2 2 0 2 0 0 162 8 2377 0.59068 1.0 1.0 0.0 0 0 0 0 0 GO:0018206 8 peptidyl-methionine modification 2 2 2 2 0 2 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:0018960 5 4-nitrophenol metabolic process 1 1 1 1 0 1 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0019048 5 modulation by virus of host process 11 11 1 1 1 0 0 0 162 11 2374 0.48464 1.0 1.0 0.0 0 0 0 0 0 GO:0019087 6 transformation of host cell by virus 2 2 1 1 1 0 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:0019287 8 isopentenyl diphosphate biosynthetic process, mevalonate pathway 1 1 1 1 0 0 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0019348 6 dolichol metabolic process 3 3 1 1 1 0 0 0 162 3 2382 0.821 1.0 1.0 0.0 0 0 0 0 0 GO:0019400 5 alditol metabolic process 6 6 1 1 0 1 0 0 162 6 2379 0.67388 1.0 1.0 0.0 0 0 0 0 0 GO:0019401 6 alditol biosynthetic process 3 3 1 1 0 1 0 0 162 3 2382 0.821 1.0 1.0 0.0 0 0 0 0 0 GO:0019408 7 dolichol biosynthetic process 2 2 1 1 1 0 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:0019413 6 acetate biosynthetic process 2 2 1 1 1 0 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:0019428 6 allantoin biosynthetic process 1 1 1 1 0 1 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0019541 8 propionate metabolic process 4 4 2 2 1 1 0 0 162 4 2381 0.76872 1.0 1.0 0.0 0 0 0 0 0 GO:0019542 8 propionate biosynthetic process 2 2 1 1 1 0 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:0019543 8 propionate catabolic process 2 2 1 1 0 1 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:0019605 8 butyrate metabolic process 1 1 1 1 0 1 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0019626 7 short-chain fatty acid catabolic process 3 3 1 1 0 1 0 0 162 3 2382 0.821 1.0 1.0 0.0 0 0 0 0 0 GO:0019674 3 NAD metabolic process 7 9 1 1 0 1 0 0 162 9 2376 0.55299 1.0 1.0 0.0 0 0 0 0 0 GO:0019722 7 calcium-mediated signaling 32 35 1 1 0 1 0 0 162 35 2350 0.098656 1.0 0.16618 0.0 0 0 0 0 0 GO:0020027 5 hemoglobin metabolic process 8 8 1 1 0 1 0 0 162 8 2377 0.59068 1.0 1.0 0.0 0 0 0 0 0 GO:0021510 5 spinal cord development 11 11 1 1 1 0 0 0 162 11 2374 0.48464 1.0 1.0 0.0 0 0 0 0 0 GO:0021516 4 dorsal spinal cord development 1 1 1 1 0 1 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0021782 5 glial cell development 22 22 1 1 0 1 0 0 162 22 2363 0.23411 1.0 0.39477 0.0 0 0 0 0 0 GO:0021784 6 postganglionic parasympathetic fiber development 1 1 1 1 0 1 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0021794 4 thalamus development 1 1 1 1 1 0 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0021854 4 hypothalamus development 7 7 2 2 2 0 0 0 162 7 2378 0.63092 1.0 1.0 0.0 0 0 0 0 0 GO:0021983 6 pituitary gland development 8 10 1 1 1 0 0 0 162 10 2375 0.51769 1.0 1.0 0.0 0 0 0 0 0 GO:0022406 3 membrane docking 13 14 1 0 0 0 0 0 162 14 2371 0.39753 1.0 1.0 0.0 0 0 0 0 0 GO:0022410 5 circadian sleep/wake cycle process 3 3 1 1 1 0 0 0 162 3 2382 0.821 1.0 1.0 0.0 0 0 0 0 0 GO:0030004 8 cellular monovalent inorganic cation homeostasis 16 17 1 1 0 0 0 0 162 17 2368 0.32601 1.0 0.62101 0.0 0 0 0 0 0 GO:0030029 3 actin filament-based process 87 94 2 2 0 2 0 0 162 94 2291 0.0018418 1.0 0.0038478 0.0 0 0 0 0 0 GO:0030036 5 actin cytoskeleton organization 81 88 2 2 0 2 0 0 162 88 2297 0.0027734 1.0 0.0058956 0.0 0 0 0 0 0 GO:0030101 5 natural killer cell activation 10 10 1 0 0 0 0 0 162 10 2375 0.51769 1.0 1.0 0.0 0 0 0 0 0 GO:0030214 7 hyaluronan catabolic process 3 3 1 1 0 0 0 0 162 3 2382 0.821 1.0 1.0 0.0 0 0 0 0 0 GO:0030300 8 regulation of intestinal cholesterol absorption 5 5 4 4 1 3 0 0 162 5 2380 0.71975 1.0 1.0 0.0 0 0 0 0 0 GO:0030318 6 melanocyte differentiation 5 5 1 1 0 1 0 0 162 5 2380 0.71975 1.0 1.0 0.0 0 0 0 0 0 GO:0030432 8 peristalsis 2 2 1 1 0 1 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:0030488 8 tRNA methylation 2 3 1 1 0 1 0 0 162 3 2382 0.821 1.0 1.0 0.0 0 0 0 0 0 GO:0030539 6 male genitalia development 5 5 1 1 1 0 0 0 162 5 2380 0.71975 1.0 1.0 0.0 0 0 0 0 0 GO:0030573 7 bile acid catabolic process 1 1 1 1 1 0 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0030643 9 cellular phosphate ion homeostasis 2 2 1 1 0 0 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:0030857 7 negative regulation of epithelial cell differentiation 17 17 1 1 0 1 0 0 162 17 2368 0.32601 1.0 0.62101 0.0 0 0 0 0 0 GO:0030901 4 midbrain development 8 8 1 1 0 1 0 0 162 8 2377 0.59068 1.0 1.0 0.0 0 0 0 0 0 GO:0030968 5 endoplasmic reticulum unfolded protein response 19 20 1 1 0 1 0 0 162 20 2365 0.26729 1.0 0.63398 0.0 0 0 0 0 0 GO:0031056 8 regulation of histone modification 33 33 1 1 0 1 0 0 162 33 2352 0.11272 1.0 0.26691 0.0 0 0 0 0 0 GO:0031058 9 positive regulation of histone modification 24 24 1 1 0 1 0 0 162 24 2361 0.20503 1.0 0.39808 0.0 0 0 0 0 0 GO:0031063 9 regulation of histone deacetylation 9 9 1 1 0 1 0 0 162 9 2376 0.55299 1.0 1.0 0.0 0 0 0 0 0 GO:0031065 10 positive regulation of histone deacetylation 8 8 1 1 0 1 0 0 162 8 2377 0.59068 1.0 1.0 0.0 0 0 0 0 0 GO:0031128 3 developmental induction 9 9 1 1 0 1 0 0 162 9 2376 0.55299 1.0 1.0 0.0 0 0 0 0 0 GO:0031214 4 biomineral tissue development 13 15 1 1 0 0 0 0 162 15 2370 0.37211 1.0 0.61863 0.0 0 0 0 0 0 GO:0031345 7 negative regulation of cell projection organization 43 47 1 1 0 0 0 0 162 47 2338 0.04425 1.0 0.07113 0.0 0 0 0 0 0 GO:0031529 7 ruffle organization 7 7 1 1 0 1 0 0 162 7 2378 0.63092 1.0 1.0 0.0 0 0 0 0 0 GO:0031532 6 actin cytoskeleton reorganization 15 15 1 1 0 1 0 0 162 15 2370 0.37211 1.0 0.61863 0.0 0 0 0 0 0 GO:0031571 9 mitotic G1 DNA damage checkpoint 4 4 2 2 1 1 0 0 162 4 2381 0.76872 1.0 1.0 0.0 0 0 0 0 0 GO:0032025 6 response to cobalt ion 13 13 1 1 0 1 0 0 162 13 2372 0.42468 1.0 1.0 0.0 0 0 0 0 0 GO:0032225 7 regulation of synaptic transmission, dopaminergic 7 7 1 1 0 1 0 0 162 7 2378 0.63092 1.0 1.0 0.0 0 0 0 0 0 GO:0032233 7 positive regulation of actin filament bundle assembly 21 24 1 1 0 1 0 0 162 24 2361 0.20503 1.0 0.39808 0.0 0 0 0 0 0 GO:0032259 3 methylation 34 41 1 1 0 1 0 0 162 41 2344 0.066105 1.0 0.10857 0.0 0 0 0 0 0 GO:0032369 6 negative regulation of lipid transport 13 14 2 2 0 2 0 0 162 14 2371 0.39753 1.0 1.0 0.0 0 0 0 0 0 GO:0032372 7 negative regulation of sterol transport 6 7 2 2 0 2 0 0 162 7 2378 0.63092 1.0 1.0 0.0 0 0 0 0 0 GO:0032375 8 negative regulation of cholesterol transport 6 7 2 2 0 2 0 0 162 7 2378 0.63092 1.0 1.0 0.0 0 0 0 0 0 GO:0032429 8 regulation of phospholipase A2 activity 3 3 1 1 0 1 0 0 162 3 2382 0.821 1.0 1.0 0.0 0 0 0 0 0 GO:0032430 9 positive regulation of phospholipase A2 activity 2 2 1 1 0 1 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:0032489 10 regulation of Cdc42 protein signal transduction 4 5 1 1 0 1 0 0 162 5 2380 0.71975 1.0 1.0 0.0 0 0 0 0 0 GO:0032677 6 regulation of interleukin-8 production 31 32 1 1 0 1 0 0 162 32 2353 0.12048 1.0 0.2626 0.0 0 0 0 0 0 GO:0032691 8 negative regulation of interleukin-1 beta production 6 6 1 1 0 1 0 0 162 6 2379 0.67388 1.0 1.0 0.0 0 0 0 0 0 GO:0032692 7 negative regulation of interleukin-1 production 9 9 1 1 0 1 0 0 162 9 2376 0.55299 1.0 1.0 0.0 0 0 0 0 0 GO:0032715 7 negative regulation of interleukin-6 production 12 13 1 1 0 1 0 0 162 13 2372 0.42468 1.0 1.0 0.0 0 0 0 0 0 GO:0032720 8 negative regulation of tumor necrosis factor production 19 19 1 1 0 1 0 0 162 19 2366 0.28559 1.0 0.62863 0.0 0 0 0 0 0 GO:0032757 7 positive regulation of interleukin-8 production 25 26 1 1 0 1 0 0 162 26 2359 0.17954 1.0 0.40644 0.0 0 0 0 0 0 GO:0032763 7 regulation of mast cell cytokine production 3 3 1 1 1 0 0 0 162 3 2382 0.821 1.0 1.0 0.0 0 0 0 0 0 GO:0032764 8 negative regulation of mast cell cytokine production 1 1 1 1 1 0 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0032788 8 saturated monocarboxylic acid metabolic process 2 2 2 2 0 2 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:0032789 8 unsaturated monocarboxylic acid metabolic process 2 2 2 2 0 2 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:0032811 8 negative regulation of epinephrine secretion 2 2 1 1 1 0 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:0032873 8 negative regulation of stress-activated MAPK cascade 7 7 1 1 1 0 0 0 162 7 2378 0.63092 1.0 1.0 0.0 0 0 0 0 0 GO:0032928 8 regulation of superoxide anion generation 19 19 1 1 0 1 0 0 162 19 2366 0.28559 1.0 0.62863 0.0 0 0 0 0 0 GO:0032930 8 positive regulation of superoxide anion generation 17 17 1 1 0 1 0 0 162 17 2368 0.32601 1.0 0.62101 0.0 0 0 0 0 0 GO:0032941 5 secretion by tissue 4 4 1 0 0 0 0 0 162 4 2381 0.76872 1.0 1.0 0.0 0 0 0 0 0 GO:0032986 7 protein-DNA complex disassembly 5 5 1 1 1 0 0 0 162 5 2380 0.71975 1.0 1.0 0.0 0 0 0 0 0 GO:0033003 6 regulation of mast cell activation 20 20 2 1 1 0 0 0 162 20 2365 0.26729 1.0 0.63398 0.0 0 0 0 0 0 GO:0033004 7 negative regulation of mast cell activation 3 3 1 1 1 0 0 0 162 3 2382 0.821 1.0 1.0 0.0 0 0 0 0 0 GO:0033006 6 regulation of mast cell activation involved in immune response 16 16 2 1 1 0 0 0 162 16 2369 0.3483 1.0 0.61907 0.0 0 0 0 0 0 GO:0033007 7 negative regulation of mast cell activation involved in immune response 3 3 1 1 1 0 0 0 162 3 2382 0.821 1.0 1.0 0.0 0 0 0 0 0 GO:0033013 5 tetrapyrrole metabolic process 14 16 2 2 1 1 0 0 162 16 2369 0.3483 1.0 0.61907 0.0 0 0 0 0 0 GO:0033014 6 tetrapyrrole biosynthetic process 8 8 1 1 0 1 0 0 162 8 2377 0.59068 1.0 1.0 0.0 0 0 0 0 0 GO:0033015 6 tetrapyrrole catabolic process 2 3 1 1 1 0 0 0 162 3 2382 0.821 1.0 1.0 0.0 0 0 0 0 0 GO:0033077 7 T cell differentiation in thymus 14 17 2 2 0 1 0 0 162 17 2368 0.32601 1.0 0.62101 0.0 0 0 0 0 0 GO:0033081 9 regulation of T cell differentiation in thymus 7 8 1 1 0 1 0 0 162 8 2377 0.59068 1.0 1.0 0.0 0 0 0 0 0 GO:0033089 10 positive regulation of T cell differentiation in thymus 4 4 1 1 0 1 0 0 162 4 2381 0.76872 1.0 1.0 0.0 0 0 0 0 0 GO:0033189 6 response to vitamin A 20 20 1 1 1 0 0 0 162 20 2365 0.26729 1.0 0.63398 0.0 0 0 0 0 0 GO:0033197 6 response to vitamin E 15 17 2 2 0 2 0 0 162 17 2368 0.32601 1.0 0.62101 0.0 0 0 0 0 0 GO:0033231 7 carbohydrate export 1 1 1 1 1 0 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0033280 6 response to vitamin D 17 20 2 2 1 0 0 0 162 20 2365 0.26729 1.0 0.63398 0.0 0 0 0 0 0 GO:0033344 9 cholesterol efflux 12 12 3 3 0 3 0 0 162 12 2373 0.45368 1.0 1.0 0.0 0 0 0 0 0 GO:0033488 8 cholesterol biosynthetic process via 24,25-dihydrolanosterol 1 1 1 1 1 0 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0033555 3 multicellular organismal response to stress 16 17 1 1 0 1 0 0 162 17 2368 0.32601 1.0 0.62101 0.0 0 0 0 0 0 GO:0033599 6 regulation of mammary gland epithelial cell proliferation 7 8 1 1 0 1 0 0 162 8 2377 0.59068 1.0 1.0 0.0 0 0 0 0 0 GO:0033601 6 positive regulation of mammary gland epithelial cell proliferation 3 3 1 1 0 1 0 0 162 3 2382 0.821 1.0 1.0 0.0 0 0 0 0 0 GO:0033604 7 negative regulation of catecholamine secretion 5 5 1 1 1 0 0 0 162 5 2380 0.71975 1.0 1.0 0.0 0 0 0 0 0 GO:0033700 8 phospholipid efflux 5 5 2 2 0 2 0 0 162 5 2380 0.71975 1.0 1.0 0.0 0 0 0 0 0 GO:0034101 6 erythrocyte homeostasis 4 4 1 1 1 0 0 0 162 4 2381 0.76872 1.0 1.0 0.0 0 0 0 0 0 GO:0034115 8 negative regulation of heterotypic cell-cell adhesion 4 4 1 1 0 1 0 0 162 4 2381 0.76872 1.0 1.0 0.0 0 0 0 0 0 GO:0034204 6 lipid translocation 7 7 1 1 1 0 0 0 162 7 2378 0.63092 1.0 1.0 0.0 0 0 0 0 0 GO:0034287 6 detection of monosaccharide stimulus 2 2 1 1 1 0 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:0034374 8 low-density lipoprotein particle remodeling 3 3 1 1 0 1 0 0 162 3 2382 0.821 1.0 1.0 0.0 0 0 0 0 0 GO:0034375 8 high-density lipoprotein particle remodeling 8 8 2 2 0 2 0 0 162 8 2377 0.59068 1.0 1.0 0.0 0 0 0 0 0 GO:0034377 7 plasma lipoprotein particle assembly 7 7 2 2 0 2 0 0 162 7 2378 0.63092 1.0 1.0 0.0 0 0 0 0 0 GO:0034380 8 high-density lipoprotein particle assembly 4 4 2 2 0 2 0 0 162 4 2381 0.76872 1.0 1.0 0.0 0 0 0 0 0 GO:0034384 4 high-density lipoprotein particle clearance 5 5 1 1 0 1 0 0 162 5 2380 0.71975 1.0 1.0 0.0 0 0 0 0 0 GO:0034391 9 regulation of smooth muscle cell apoptotic process 11 13 1 1 0 1 0 0 162 13 2372 0.42468 1.0 1.0 0.0 0 0 0 0 0 GO:0034392 10 negative regulation of smooth muscle cell apoptotic process 6 8 1 1 0 1 0 0 162 8 2377 0.59068 1.0 1.0 0.0 0 0 0 0 0 GO:0034395 9 regulation of transcription from RNA polymerase II promoter in response to iron 2 2 2 2 2 0 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:0034418 5 urate biosynthetic process 2 2 1 1 0 0 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:0034471 9 ncRNA 5'-end processing 3 3 2 1 0 2 0 0 162 3 2382 0.821 1.0 1.0 0.0 0 0 0 0 0 GO:0034629 6 cellular protein-containing complex localization 4 4 1 1 0 1 0 0 162 4 2381 0.76872 1.0 1.0 0.0 0 0 0 0 0 GO:0034696 6 response to prostaglandin F 2 2 1 1 0 1 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:0034755 8 iron ion transmembrane transport 4 4 1 1 1 0 0 0 162 4 2381 0.76872 1.0 1.0 0.0 0 0 0 0 0 GO:0035023 9 regulation of Rho protein signal transduction 18 19 1 1 0 1 0 0 162 19 2366 0.28559 1.0 0.62863 0.0 0 0 0 0 0 GO:0035025 10 positive regulation of Rho protein signal transduction 9 9 1 1 0 1 0 0 162 9 2376 0.55299 1.0 1.0 0.0 0 0 0 0 0 GO:0035337 8 fatty-acyl-CoA metabolic process 4 6 1 1 0 1 0 0 162 6 2379 0.67388 1.0 1.0 0.0 0 0 0 0 0 GO:0035455 6 response to interferon-alpha 11 11 1 1 1 0 0 0 162 11 2374 0.48464 1.0 1.0 0.0 0 0 0 0 0 GO:0035457 7 cellular response to interferon-alpha 7 7 1 1 1 0 0 0 162 7 2378 0.63092 1.0 1.0 0.0 0 0 0 0 0 GO:0035493 8 SNARE complex assembly 6 6 1 0 0 0 0 0 162 6 2379 0.67388 1.0 1.0 0.0 0 0 0 0 0 GO:0035627 7 ceramide transport 3 3 1 1 1 0 0 0 162 3 2382 0.821 1.0 1.0 0.0 0 0 0 0 0 GO:0035633 7 maintenance of blood-brain barrier 3 3 1 1 1 0 0 0 162 3 2382 0.821 1.0 1.0 0.0 0 0 0 0 0 GO:0035674 7 tricarboxylic acid transmembrane transport 1 1 1 0 0 1 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0035725 8 sodium ion transmembrane transport 12 12 1 1 0 1 0 0 162 12 2373 0.45368 1.0 1.0 0.0 0 0 0 0 0 GO:0035873 7 lactate transmembrane transport 2 2 1 1 1 0 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:0035879 8 plasma membrane lactate transport 2 2 1 1 1 0 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:0035999 6 tetrahydrofolate interconversion 3 3 1 1 0 1 0 0 162 3 2382 0.821 1.0 1.0 0.0 0 0 0 0 0 GO:0036230 5 granulocyte activation 12 12 1 0 0 0 0 0 162 12 2373 0.45368 1.0 1.0 0.0 0 0 0 0 0 GO:0038161 6 prolactin signaling pathway 1 1 1 1 1 0 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0038166 6 angiotensin-activated signaling pathway 3 3 1 1 0 1 0 0 162 3 2382 0.821 1.0 1.0 0.0 0 0 0 0 0 GO:0040019 6 positive regulation of embryonic development 15 15 1 1 0 1 0 0 162 15 2370 0.37211 1.0 0.61863 0.0 0 0 0 0 0 GO:0042063 6 gliogenesis 4 4 1 1 0 0 0 0 162 4 2381 0.76872 1.0 1.0 0.0 0 0 0 0 0 GO:0042102 9 positive regulation of T cell proliferation 34 36 1 1 0 1 0 0 162 36 2349 0.092294 1.0 0.16685 0.0 0 0 0 0 0 GO:0042119 6 neutrophil activation 10 10 1 0 0 0 0 0 162 10 2375 0.51769 1.0 1.0 0.0 0 0 0 0 0 GO:0042129 8 regulation of T cell proliferation 55 58 1 1 0 1 0 0 162 58 2327 0.021145 1.0 0.049371 0.0 0 0 0 0 0 GO:0042157 5 lipoprotein metabolic process 11 11 2 2 0 2 0 0 162 11 2374 0.48464 1.0 1.0 0.0 0 0 0 0 0 GO:0042158 6 lipoprotein biosynthetic process 3 3 1 1 0 1 0 0 162 3 2382 0.821 1.0 1.0 0.0 0 0 0 0 0 GO:0042167 6 heme catabolic process 2 2 1 1 1 0 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:0042168 5 heme metabolic process 11 11 2 2 1 1 0 0 162 11 2374 0.48464 1.0 1.0 0.0 0 0 0 0 0 GO:0042278 6 purine nucleoside metabolic process 9 11 1 1 0 1 0 0 162 11 2374 0.48464 1.0 1.0 0.0 0 0 0 0 0 GO:0042310 8 vasoconstriction 6 7 2 2 1 1 0 0 162 7 2378 0.63092 1.0 1.0 0.0 0 0 0 0 0 GO:0042416 6 dopamine biosynthetic process 6 6 1 1 0 1 0 0 162 6 2379 0.67388 1.0 1.0 0.0 0 0 0 0 0 GO:0042417 5 dopamine metabolic process 10 12 1 1 0 1 0 0 162 12 2373 0.45368 1.0 1.0 0.0 0 0 0 0 0 GO:0042428 5 serotonin metabolic process 5 6 1 1 1 0 0 0 162 6 2379 0.67388 1.0 1.0 0.0 0 0 0 0 0 GO:0042430 5 indole-containing compound metabolic process 11 12 1 1 1 0 0 0 162 12 2373 0.45368 1.0 1.0 0.0 0 0 0 0 0 GO:0042474 5 middle ear morphogenesis 4 4 1 1 1 0 0 0 162 4 2381 0.76872 1.0 1.0 0.0 0 0 0 0 0 GO:0042538 6 hyperosmotic salinity response 1 1 1 1 1 0 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0042541 6 hemoglobin biosynthetic process 5 5 1 1 0 1 0 0 162 5 2380 0.71975 1.0 1.0 0.0 0 0 0 0 0 GO:0042558 5 pteridine-containing compound metabolic process 8 10 1 1 0 1 0 0 162 10 2375 0.51769 1.0 1.0 0.0 0 0 0 0 0 GO:0042573 8 retinoic acid metabolic process 6 6 2 2 1 1 0 0 162 6 2379 0.67388 1.0 1.0 0.0 0 0 0 0 0 GO:0042747 6 circadian sleep/wake cycle, REM sleep 3 3 1 1 1 0 0 0 162 3 2382 0.821 1.0 1.0 0.0 0 0 0 0 0 GO:0042756 4 drinking behavior 3 4 1 1 0 1 0 0 162 4 2381 0.76872 1.0 1.0 0.0 0 0 0 0 0 GO:0042780 10 tRNA 3'-end processing 1 1 1 1 0 1 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0042790 9 nucleolar large rRNA transcription by RNA polymerase I 1 1 1 1 0 1 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0042904 8 9-cis-retinoic acid biosynthetic process 2 2 1 1 0 1 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:0042905 9 9-cis-retinoic acid metabolic process 2 2 1 1 0 1 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:0042976 10 activation of Janus kinase activity 6 6 2 2 1 1 0 0 162 6 2379 0.67388 1.0 1.0 0.0 0 0 0 0 0 GO:0043001 7 Golgi to plasma membrane protein transport 3 3 1 0 0 0 0 0 162 3 2382 0.821 1.0 1.0 0.0 0 0 0 0 0 GO:0043113 5 receptor clustering 15 15 1 1 0 1 0 0 162 15 2370 0.37211 1.0 0.61863 0.0 0 0 0 0 0 GO:0043215 6 daunorubicin transport 1 1 1 1 1 0 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0043266 8 regulation of potassium ion transport 22 23 2 1 1 0 0 0 162 23 2362 0.21909 1.0 0.39574 0.0 0 0 0 0 0 GO:0043299 5 leukocyte degranulation 8 8 1 0 0 0 0 0 162 8 2377 0.59068 1.0 1.0 0.0 0 0 0 0 0 GO:0043300 6 regulation of leukocyte degranulation 20 20 2 1 1 0 0 0 162 20 2365 0.26729 1.0 0.63398 0.0 0 0 0 0 0 GO:0043301 7 negative regulation of leukocyte degranulation 4 4 1 1 1 0 0 0 162 4 2381 0.76872 1.0 1.0 0.0 0 0 0 0 0 GO:0043304 7 regulation of mast cell degranulation 15 15 2 1 1 0 0 0 162 15 2370 0.37211 1.0 0.61863 0.0 0 0 0 0 0 GO:0043305 7 negative regulation of mast cell degranulation 2 2 1 1 1 0 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:0043307 6 eosinophil activation 2 2 1 0 0 0 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:0043308 6 eosinophil degranulation 2 2 1 0 0 0 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:0043312 6 neutrophil degranulation 3 3 1 0 0 0 0 0 162 3 2382 0.821 1.0 1.0 0.0 0 0 0 0 0 GO:0043320 6 natural killer cell degranulation 3 3 1 0 0 0 0 0 162 3 2382 0.821 1.0 1.0 0.0 0 0 0 0 0 GO:0043414 4 macromolecule methylation 28 34 1 1 0 1 0 0 162 34 2351 0.10545 1.0 0.16633 0.0 0 0 0 0 0 GO:0043473 2 pigmentation 14 14 1 1 1 0 0 0 162 14 2371 0.39753 1.0 1.0 0.0 0 0 0 0 0 GO:0043534 8 blood vessel endothelial cell migration 13 13 1 1 0 1 0 0 162 13 2372 0.42468 1.0 1.0 0.0 0 0 0 0 0 GO:0043542 7 endothelial cell migration 25 26 1 1 0 1 0 0 162 26 2359 0.17954 1.0 0.40644 0.0 0 0 0 0 0 GO:0043619 9 regulation of transcription from RNA polymerase II promoter in response to oxidative stress 6 6 1 1 1 0 0 0 162 6 2379 0.67388 1.0 1.0 0.0 0 0 0 0 0 GO:0043649 7 dicarboxylic acid catabolic process 4 4 1 1 0 1 0 0 162 4 2381 0.76872 1.0 1.0 0.0 0 0 0 0 0 GO:0043691 9 reverse cholesterol transport 7 7 2 2 0 2 0 0 162 7 2378 0.63092 1.0 1.0 0.0 0 0 0 0 0 GO:0043696 3 dedifferentiation 2 2 1 1 0 0 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:0043697 4 cell dedifferentiation 2 2 1 1 0 0 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:0043900 4 regulation of multi-organism process 30 31 1 1 0 1 0 0 162 31 2354 0.12877 1.0 0.25922 0.0 0 0 0 0 0 GO:0043949 7 regulation of cAMP-mediated signaling 11 11 1 1 0 1 0 0 162 11 2374 0.48464 1.0 1.0 0.0 0 0 0 0 0 GO:0043950 8 positive regulation of cAMP-mediated signaling 6 6 1 1 0 1 0 0 162 6 2379 0.67388 1.0 1.0 0.0 0 0 0 0 0 GO:0044003 5 modulation by symbiont of host process 13 14 1 1 1 0 0 0 162 14 2371 0.39753 1.0 1.0 0.0 0 0 0 0 0 GO:0044036 5 cell wall macromolecule metabolic process 1 1 1 1 1 0 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0044060 6 regulation of endocrine process 18 18 2 2 0 2 0 0 162 18 2367 0.30513 1.0 0.62425 0.0 0 0 0 0 0 GO:0044091 5 membrane biogenesis 1 1 1 1 0 1 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0044320 6 cellular response to leptin stimulus 5 5 1 1 1 0 0 0 162 5 2380 0.71975 1.0 1.0 0.0 0 0 0 0 0 GO:0044321 5 response to leptin 8 9 2 2 1 1 0 0 162 9 2376 0.55299 1.0 1.0 0.0 0 0 0 0 0 GO:0044336 9 canonical Wnt signaling pathway involved in negative regulation of apoptotic process 1 1 1 1 1 0 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0044337 9 canonical Wnt signaling pathway involved in positive regulation of apoptotic process 1 1 1 1 1 0 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0044359 4 modulation of molecular function in other organism 2 2 1 1 1 0 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:0044362 5 negative regulation of molecular function in other organism 2 2 1 1 1 0 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:0044375 6 regulation of peroxisome size 1 1 1 1 0 1 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0044752 6 response to human chorionic gonadotropin 6 6 1 1 1 0 0 0 162 6 2379 0.67388 1.0 1.0 0.0 0 0 0 0 0 GO:0044783 9 G1 DNA damage checkpoint 4 4 2 2 1 1 0 0 162 4 2381 0.76872 1.0 1.0 0.0 0 0 0 0 0 GO:0044788 5 modulation by host of viral process 11 12 1 1 1 0 0 0 162 12 2373 0.45368 1.0 1.0 0.0 0 0 0 0 0 GO:0044793 6 negative regulation by host of viral process 5 5 1 1 1 0 0 0 162 5 2380 0.71975 1.0 1.0 0.0 0 0 0 0 0 GO:0044819 8 mitotic G1/S transition checkpoint 5 5 2 2 1 1 0 0 162 5 2380 0.71975 1.0 1.0 0.0 0 0 0 0 0 GO:0044866 7 modulation by host of viral exo-alpha-sialidase activity 1 1 1 1 1 0 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0044867 6 modulation by host of viral catalytic activity 1 1 1 1 1 0 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0044868 5 modulation by host of viral molecular function 1 1 1 1 1 0 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0044869 7 negative regulation by host of viral exo-alpha-sialidase activity 1 1 1 1 1 0 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0044870 6 modulation by host of viral glycoprotein metabolic process 1 1 1 1 1 0 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0044871 7 negative regulation by host of viral glycoprotein metabolic process 1 1 1 1 1 0 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0045023 4 G0 to G1 transition 1 1 1 1 1 0 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0045055 6 regulated exocytosis 21 22 1 0 0 0 0 0 162 22 2363 0.23411 1.0 0.39477 0.0 0 0 0 0 0 GO:0045088 6 regulation of innate immune response 43 46 1 1 0 1 0 0 162 46 2339 0.047315 1.0 0.11559 0.0 0 0 0 0 0 GO:0045332 7 phospholipid translocation 7 7 1 1 1 0 0 0 162 7 2378 0.63092 1.0 1.0 0.0 0 0 0 0 0 GO:0045414 7 regulation of interleukin-8 biosynthetic process 9 10 1 1 0 1 0 0 162 10 2375 0.51769 1.0 1.0 0.0 0 0 0 0 0 GO:0045416 8 positive regulation of interleukin-8 biosynthetic process 8 9 1 1 0 1 0 0 162 9 2376 0.55299 1.0 1.0 0.0 0 0 0 0 0 GO:0045580 8 regulation of T cell differentiation 44 47 1 1 0 1 0 0 162 47 2338 0.04425 1.0 0.07113 0.0 0 0 0 0 0 GO:0045582 9 positive regulation of T cell differentiation 34 35 1 1 0 1 0 0 162 35 2350 0.098656 1.0 0.16618 0.0 0 0 0 0 0 GO:0045619 7 regulation of lymphocyte differentiation 50 53 1 1 0 1 0 0 162 53 2332 0.029591 1.0 0.04668 0.0 0 0 0 0 0 GO:0045621 8 positive regulation of lymphocyte differentiation 36 37 1 1 0 1 0 0 162 37 2348 0.086339 1.0 0.16832 0.0 0 0 0 0 0 GO:0045656 9 negative regulation of monocyte differentiation 3 3 3 3 2 0 0 0 162 3 2382 0.821 1.0 1.0 0.0 0 0 0 0 0 GO:0045668 7 negative regulation of osteoblast differentiation 7 8 1 1 0 0 0 0 162 8 2377 0.59068 1.0 1.0 0.0 0 0 0 0 0 GO:0045721 7 negative regulation of gluconeogenesis 6 6 1 1 1 0 0 0 162 6 2379 0.67388 1.0 1.0 0.0 0 0 0 0 0 GO:0045725 8 positive regulation of glycogen biosynthetic process 6 6 1 1 1 0 0 0 162 6 2379 0.67388 1.0 1.0 0.0 0 0 0 0 0 GO:0045727 8 positive regulation of translation 24 28 1 1 1 0 0 0 162 28 2357 0.1572 1.0 0.25527 0.0 0 0 0 0 0 GO:0045737 9 positive regulation of cyclin-dependent protein serine/threonine kinase activity 17 17 1 1 0 1 0 0 162 17 2368 0.32601 1.0 0.62101 0.0 0 0 0 0 0 GO:0045796 8 negative regulation of intestinal cholesterol absorption 2 2 1 1 0 1 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:0045797 8 positive regulation of intestinal cholesterol absorption 1 1 1 1 1 0 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0045821 7 positive regulation of glycolytic process 11 12 3 3 2 1 0 0 162 12 2373 0.45368 1.0 1.0 0.0 0 0 0 0 0 GO:0045824 7 negative regulation of innate immune response 16 19 1 1 0 1 0 0 162 19 2366 0.28559 1.0 0.62863 0.0 0 0 0 0 0 GO:0045838 5 positive regulation of membrane potential 8 8 1 1 1 0 0 0 162 8 2377 0.59068 1.0 1.0 0.0 0 0 0 0 0 GO:0045920 7 negative regulation of exocytosis 8 8 1 1 1 0 0 0 162 8 2377 0.59068 1.0 1.0 0.0 0 0 0 0 0 GO:0046039 8 GTP metabolic process 3 3 1 1 0 1 0 0 162 3 2382 0.821 1.0 1.0 0.0 0 0 0 0 0 GO:0046128 7 purine ribonucleoside metabolic process 9 11 1 1 0 1 0 0 162 11 2374 0.48464 1.0 1.0 0.0 0 0 0 0 0 GO:0046148 4 pigment biosynthetic process 8 10 1 1 0 1 0 0 162 10 2375 0.51769 1.0 1.0 0.0 0 0 0 0 0 GO:0046149 4 pigment catabolic process 2 2 1 1 1 0 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:0046168 6 glycerol-3-phosphate catabolic process 1 1 1 1 0 1 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0046327 8 glycerol biosynthetic process from pyruvate 2 2 1 1 0 1 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:0046339 7 diacylglycerol metabolic process 2 4 1 1 0 1 0 0 162 4 2381 0.76872 1.0 1.0 0.0 0 0 0 0 0 GO:0046340 8 diacylglycerol catabolic process 1 1 1 1 0 1 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0046434 5 organophosphate catabolic process 16 20 2 2 0 2 0 0 162 20 2365 0.26729 1.0 0.63398 0.0 0 0 0 0 0 GO:0046456 6 icosanoid biosynthetic process 13 16 4 4 2 2 0 0 162 16 2369 0.3483 1.0 0.61907 0.0 0 0 0 0 0 GO:0046459 7 short-chain fatty acid metabolic process 7 7 4 4 1 3 0 0 162 7 2378 0.63092 1.0 1.0 0.0 0 0 0 0 0 GO:0046462 7 monoacylglycerol metabolic process 2 3 1 1 0 1 0 0 162 3 2382 0.821 1.0 1.0 0.0 0 0 0 0 0 GO:0046490 6 isopentenyl diphosphate metabolic process 2 2 2 2 0 1 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:0046501 6 protoporphyrinogen IX metabolic process 4 4 1 1 0 1 0 0 162 4 2381 0.76872 1.0 1.0 0.0 0 0 0 0 0 GO:0046578 8 regulation of Ras protein signal transduction 34 36 1 1 0 1 0 0 162 36 2349 0.092294 1.0 0.16685 0.0 0 0 0 0 0 GO:0046579 9 positive regulation of Ras protein signal transduction 15 16 1 1 0 1 0 0 162 16 2369 0.3483 1.0 0.61907 0.0 0 0 0 0 0 GO:0046596 6 regulation of viral entry into host cell 10 10 1 1 1 0 0 0 162 10 2375 0.51769 1.0 1.0 0.0 0 0 0 0 0 GO:0046597 7 negative regulation of viral entry into host cell 5 5 1 1 1 0 0 0 162 5 2380 0.71975 1.0 1.0 0.0 0 0 0 0 0 GO:0046653 6 tetrahydrofolate metabolic process 5 6 1 1 0 1 0 0 162 6 2379 0.67388 1.0 1.0 0.0 0 0 0 0 0 GO:0046661 5 male sex differentiation 4 4 1 1 1 0 0 0 162 4 2381 0.76872 1.0 1.0 0.0 0 0 0 0 0 GO:0046722 7 lactic acid secretion 1 1 1 1 1 0 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0046825 8 regulation of protein export from nucleus 11 11 1 1 0 1 0 0 162 11 2374 0.48464 1.0 1.0 0.0 0 0 0 0 0 GO:0046827 8 positive regulation of protein export from nucleus 6 6 1 1 0 1 0 0 162 6 2379 0.67388 1.0 1.0 0.0 0 0 0 0 0 GO:0046835 5 carbohydrate phosphorylation 5 5 1 1 1 0 0 0 162 5 2380 0.71975 1.0 1.0 0.0 0 0 0 0 0 GO:0046879 6 hormone secretion 20 20 1 0 0 0 0 0 162 20 2365 0.26729 1.0 0.63398 0.0 0 0 0 0 0 GO:0046949 8 fatty-acyl-CoA biosynthetic process 4 6 1 1 0 1 0 0 162 6 2379 0.67388 1.0 1.0 0.0 0 0 0 0 0 GO:0046950 4 cellular ketone body metabolic process 3 3 2 2 1 1 0 0 162 3 2382 0.821 1.0 1.0 0.0 0 0 0 0 0 GO:0046951 5 ketone body biosynthetic process 1 1 1 1 0 1 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0046952 5 ketone body catabolic process 2 2 1 1 1 0 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:0047484 6 regulation of response to osmotic stress 5 5 1 1 1 0 0 0 162 5 2380 0.71975 1.0 1.0 0.0 0 0 0 0 0 GO:0048048 6 embryonic eye morphogenesis 5 5 1 1 0 1 0 0 162 5 2380 0.71975 1.0 1.0 0.0 0 0 0 0 0 GO:0048147 7 negative regulation of fibroblast proliferation 11 11 1 1 1 0 0 0 162 11 2374 0.48464 1.0 1.0 0.0 0 0 0 0 0 GO:0048240 4 sperm capacitation 5 5 1 1 0 1 0 0 162 5 2380 0.71975 1.0 1.0 0.0 0 0 0 0 0 GO:0048252 8 lauric acid metabolic process 3 4 3 3 1 2 0 0 162 4 2381 0.76872 1.0 1.0 0.0 0 0 0 0 0 GO:0048278 5 vesicle docking 8 8 1 0 0 0 0 0 162 8 2377 0.59068 1.0 1.0 0.0 0 0 0 0 0 GO:0048284 6 organelle fusion 10 10 1 0 0 0 0 0 162 10 2375 0.51769 1.0 1.0 0.0 0 0 0 0 0 GO:0048483 5 autonomic nervous system development 1 1 1 1 0 1 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0048484 5 enteric nervous system development 2 2 1 1 0 1 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:0048485 5 sympathetic nervous system development 6 7 1 1 0 1 0 0 162 7 2378 0.63092 1.0 1.0 0.0 0 0 0 0 0 GO:0048488 6 synaptic vesicle endocytosis 9 11 1 0 0 0 0 0 162 11 2374 0.48464 1.0 1.0 0.0 0 0 0 0 0 GO:0048536 6 spleen development 11 12 1 1 1 0 0 0 162 12 2373 0.45368 1.0 1.0 0.0 0 0 0 0 0 GO:0048562 5 embryonic organ morphogenesis 19 20 1 1 0 1 0 0 162 20 2365 0.26729 1.0 0.63398 0.0 0 0 0 0 0 GO:0048592 6 eye morphogenesis 16 16 1 1 0 1 0 0 162 16 2369 0.3483 1.0 0.61907 0.0 0 0 0 0 0 GO:0048670 8 regulation of collateral sprouting 3 3 1 1 0 0 0 0 162 3 2382 0.821 1.0 1.0 0.0 0 0 0 0 0 GO:0048671 8 negative regulation of collateral sprouting 2 2 1 1 0 0 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:0048679 8 regulation of axon regeneration 5 6 1 1 0 0 0 0 162 6 2379 0.67388 1.0 1.0 0.0 0 0 0 0 0 GO:0048681 8 negative regulation of axon regeneration 1 1 1 1 0 0 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0048683 9 regulation of collateral sprouting of intact axon in response to injury 1 1 1 1 0 0 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0048685 9 negative regulation of collateral sprouting of intact axon in response to injury 1 1 1 1 0 0 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0048705 5 skeletal system morphogenesis 20 21 1 1 1 0 0 0 162 21 2364 0.25015 1.0 0.64016 0.0 0 0 0 0 0 GO:0048821 6 erythrocyte development 8 9 1 1 0 1 0 0 162 9 2376 0.55299 1.0 1.0 0.0 0 0 0 0 0 GO:0050433 6 regulation of catecholamine secretion 14 14 1 1 1 0 0 0 162 14 2371 0.39753 1.0 1.0 0.0 0 0 0 0 0 GO:0050711 7 negative regulation of interleukin-1 secretion 3 3 1 1 0 1 0 0 162 3 2382 0.821 1.0 1.0 0.0 0 0 0 0 0 GO:0050713 8 negative regulation of interleukin-1 beta secretion 2 2 1 1 0 1 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:0050771 9 negative regulation of axonogenesis 12 13 1 1 0 0 0 0 162 13 2372 0.42468 1.0 1.0 0.0 0 0 0 0 0 GO:0050777 6 negative regulation of immune response 45 49 4 4 1 3 0 0 162 49 2336 0.0387 1.0 0.071716 0.0 0 0 0 0 0 GO:0050805 6 negative regulation of synaptic transmission 19 19 1 1 0 1 0 0 162 19 2366 0.28559 1.0 0.62863 0.0 0 0 0 0 0 GO:0050808 6 synapse organization 39 44 1 1 0 1 0 0 162 44 2341 0.054091 1.0 0.11115 0.0 0 0 0 0 0 GO:0050851 8 antigen receptor-mediated signaling pathway 30 33 1 1 0 1 0 0 162 33 2352 0.11272 1.0 0.26691 0.0 0 0 0 0 0 GO:0050852 9 T cell receptor signaling pathway 19 22 1 1 0 1 0 0 162 22 2363 0.23411 1.0 0.39477 0.0 0 0 0 0 0 GO:0050886 4 endocrine process 7 10 1 1 0 1 0 0 162 10 2375 0.51769 1.0 1.0 0.0 0 0 0 0 0 GO:0050906 4 detection of stimulus involved in sensory perception 21 22 2 2 1 1 0 0 162 22 2363 0.23411 1.0 0.39477 0.0 0 0 0 0 0 GO:0050907 5 detection of chemical stimulus involved in sensory perception 4 4 1 1 0 1 0 0 162 4 2381 0.76872 1.0 1.0 0.0 0 0 0 0 0 GO:0050910 5 detection of mechanical stimulus involved in sensory perception of sound 4 4 1 1 1 0 0 0 162 4 2381 0.76872 1.0 1.0 0.0 0 0 0 0 0 GO:0050911 6 detection of chemical stimulus involved in sensory perception of smell 2 2 1 1 0 1 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:0050919 5 negative chemotaxis 5 5 1 1 0 1 0 0 162 5 2380 0.71975 1.0 1.0 0.0 0 0 0 0 0 GO:0050931 5 pigment cell differentiation 6 6 1 1 0 1 0 0 162 6 2379 0.67388 1.0 1.0 0.0 0 0 0 0 0 GO:0050974 5 detection of mechanical stimulus involved in sensory perception 15 16 1 1 1 0 0 0 162 16 2369 0.3483 1.0 0.61907 0.0 0 0 0 0 0 GO:0050982 5 detection of mechanical stimulus 19 20 1 1 1 0 0 0 162 20 2365 0.26729 1.0 0.63398 0.0 0 0 0 0 0 GO:0050992 6 dimethylallyl diphosphate biosynthetic process 1 1 1 1 0 1 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0050993 6 dimethylallyl diphosphate metabolic process 1 1 1 1 0 1 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0050995 7 negative regulation of lipid catabolic process 10 11 1 1 0 1 0 0 162 11 2374 0.48464 1.0 1.0 0.0 0 0 0 0 0 GO:0051004 7 regulation of lipoprotein lipase activity 8 8 1 1 0 1 0 0 162 8 2377 0.59068 1.0 1.0 0.0 0 0 0 0 0 GO:0051006 8 positive regulation of lipoprotein lipase activity 5 5 1 1 0 1 0 0 162 5 2380 0.71975 1.0 1.0 0.0 0 0 0 0 0 GO:0051030 6 snRNA transport 1 2 1 1 0 1 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:0051056 7 regulation of small GTPase mediated signal transduction 38 40 1 1 0 1 0 0 162 40 2345 0.070672 1.0 0.17717 0.0 0 0 0 0 0 GO:0051057 8 positive regulation of small GTPase mediated signal transduction 17 18 1 1 0 1 0 0 162 18 2367 0.30513 1.0 0.62425 0.0 0 0 0 0 0 GO:0051156 5 glucose 6-phosphate metabolic process 5 5 1 1 1 0 0 0 162 5 2380 0.71975 1.0 1.0 0.0 0 0 0 0 0 GO:0051187 5 cofactor catabolic process 18 20 1 1 1 0 0 0 162 20 2365 0.26729 1.0 0.63398 0.0 0 0 0 0 0 GO:0051262 8 protein tetramerization 23 25 1 1 0 1 0 0 162 25 2360 0.19186 1.0 0.40169 0.0 0 0 0 0 0 GO:0051289 9 protein homotetramerization 12 14 1 1 0 1 0 0 162 14 2371 0.39753 1.0 1.0 0.0 0 0 0 0 0 GO:0051302 5 regulation of cell division 50 51 1 1 1 0 0 0 162 51 2334 0.033842 1.0 0.073867 0.0 0 0 0 0 0 GO:0051482 12 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway 7 7 1 1 0 1 0 0 162 7 2378 0.63092 1.0 1.0 0.0 0 0 0 0 0 GO:0051495 8 positive regulation of cytoskeleton organization 51 55 1 1 0 1 0 0 162 55 2330 0.025871 1.0 0.046944 0.0 0 0 0 0 0 GO:0051496 8 positive regulation of stress fiber assembly 18 21 1 1 0 1 0 0 162 21 2364 0.25015 1.0 0.64016 0.0 0 0 0 0 0 GO:0051580 5 regulation of neurotransmitter uptake 8 9 1 1 0 1 0 0 162 9 2376 0.55299 1.0 1.0 0.0 0 0 0 0 0 GO:0051584 6 regulation of dopamine uptake involved in synaptic transmission 4 4 1 1 0 1 0 0 162 4 2381 0.76872 1.0 1.0 0.0 0 0 0 0 0 GO:0051588 6 regulation of neurotransmitter transport 35 42 2 1 0 1 0 0 162 42 2343 0.061832 1.0 0.10887 0.0 0 0 0 0 0 GO:0051594 8 detection of glucose 2 2 1 1 1 0 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:0051599 4 response to hydrostatic pressure 6 6 1 1 1 0 0 0 162 6 2379 0.67388 1.0 1.0 0.0 0 0 0 0 0 GO:0051668 4 localization within membrane 22 22 1 1 0 1 0 0 162 22 2363 0.23411 1.0 0.39477 0.0 0 0 0 0 0 GO:0051701 4 interaction with host 20 21 1 1 1 0 0 0 162 21 2364 0.25015 1.0 0.64016 0.0 0 0 0 0 0 GO:0051782 6 negative regulation of cell division 7 7 1 1 1 0 0 0 162 7 2378 0.63092 1.0 1.0 0.0 0 0 0 0 0 GO:0051790 7 short-chain fatty acid biosynthetic process 2 2 1 1 1 0 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:0051930 8 regulation of sensory perception of pain 14 14 1 1 0 1 0 0 162 14 2371 0.39753 1.0 1.0 0.0 0 0 0 0 0 GO:0051931 7 regulation of sensory perception 14 14 1 1 0 1 0 0 162 14 2371 0.39753 1.0 1.0 0.0 0 0 0 0 0 GO:0051940 6 regulation of catecholamine uptake involved in synaptic transmission 4 4 1 1 0 1 0 0 162 4 2381 0.76872 1.0 1.0 0.0 0 0 0 0 0 GO:0051952 6 regulation of amine transport 29 30 2 2 1 1 0 0 162 30 2355 0.13763 1.0 0.25683 0.0 0 0 0 0 0 GO:0051953 6 negative regulation of amine transport 9 10 1 1 1 0 0 0 162 10 2375 0.51769 1.0 1.0 0.0 0 0 0 0 0 GO:0051972 6 regulation of telomerase activity 16 17 1 1 1 0 0 0 162 17 2368 0.32601 1.0 0.62101 0.0 0 0 0 0 0 GO:0051973 7 positive regulation of telomerase activity 13 14 1 1 1 0 0 0 162 14 2371 0.39753 1.0 1.0 0.0 0 0 0 0 0 GO:0052199 6 negative regulation of catalytic activity in other organism involved in symbiotic interaction 1 1 1 1 1 0 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0052203 5 modulation of catalytic activity in other organism involved in symbiotic interaction 1 1 1 1 1 0 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0052204 6 negative regulation of molecular function in other organism involved in symbiotic interaction 2 2 1 1 1 0 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:0052205 5 modulation of molecular function in other organism involved in symbiotic interaction 2 2 1 1 1 0 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:0052372 5 modulation by symbiont of entry into host 11 11 1 1 1 0 0 0 162 11 2374 0.48464 1.0 1.0 0.0 0 0 0 0 0 GO:0052403 7 negative regulation by host of symbiont catalytic activity 1 1 1 1 1 0 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0052405 6 negative regulation by host of symbiont molecular function 2 2 1 1 1 0 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:0052422 6 modulation by host of symbiont catalytic activity 1 1 1 1 1 0 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0052428 5 modulation by host of symbiont molecular function 2 2 1 1 1 0 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:0052646 5 alditol phosphate metabolic process 2 2 1 1 0 1 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:0052651 8 monoacylglycerol catabolic process 2 2 1 1 0 1 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:0055062 9 phosphate ion homeostasis 3 3 1 1 0 0 0 0 162 3 2382 0.821 1.0 1.0 0.0 0 0 0 0 0 GO:0055067 8 monovalent inorganic cation homeostasis 21 23 2 2 0 1 0 0 162 23 2362 0.21909 1.0 0.39574 0.0 0 0 0 0 0 GO:0055078 9 sodium ion homeostasis 6 7 1 1 0 0 0 0 162 7 2378 0.63092 1.0 1.0 0.0 0 0 0 0 0 GO:0055091 7 phospholipid homeostasis 4 4 1 1 0 1 0 0 162 4 2381 0.76872 1.0 1.0 0.0 0 0 0 0 0 GO:0060041 4 retina development in camera-type eye 15 16 1 1 0 1 0 0 162 16 2369 0.3483 1.0 0.61907 0.0 0 0 0 0 0 GO:0060046 6 regulation of acrosome reaction 4 4 1 1 0 1 0 0 162 4 2381 0.76872 1.0 1.0 0.0 0 0 0 0 0 GO:0060070 8 canonical Wnt signaling pathway 13 16 1 1 1 0 0 0 162 16 2369 0.3483 1.0 0.61907 0.0 0 0 0 0 0 GO:0060218 6 hematopoietic stem cell differentiation 2 2 1 1 0 0 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:0060251 6 regulation of glial cell proliferation 16 18 1 1 1 0 0 0 162 18 2367 0.30513 1.0 0.62425 0.0 0 0 0 0 0 GO:0060252 7 positive regulation of glial cell proliferation 9 10 1 1 1 0 0 0 162 10 2375 0.51769 1.0 1.0 0.0 0 0 0 0 0 GO:0060292 5 long-term synaptic depression 6 6 1 1 0 1 0 0 162 6 2379 0.67388 1.0 1.0 0.0 0 0 0 0 0 GO:0060330 6 regulation of response to interferon-gamma 7 7 1 1 0 1 0 0 162 7 2378 0.63092 1.0 1.0 0.0 0 0 0 0 0 GO:0060331 7 negative regulation of response to interferon-gamma 4 4 1 1 0 1 0 0 162 4 2381 0.76872 1.0 1.0 0.0 0 0 0 0 0 GO:0060334 7 regulation of interferon-gamma-mediated signaling pathway 7 7 1 1 0 1 0 0 162 7 2378 0.63092 1.0 1.0 0.0 0 0 0 0 0 GO:0060336 8 negative regulation of interferon-gamma-mediated signaling pathway 4 4 1 1 0 1 0 0 162 4 2381 0.76872 1.0 1.0 0.0 0 0 0 0 0 GO:0060343 4 trabecula formation 7 7 1 1 1 0 0 0 162 7 2378 0.63092 1.0 1.0 0.0 0 0 0 0 0 GO:0060345 5 spleen trabecula formation 1 1 1 1 1 0 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0060353 5 regulation of cell adhesion molecule production 7 7 1 1 0 1 0 0 162 7 2378 0.63092 1.0 1.0 0.0 0 0 0 0 0 GO:0060354 6 negative regulation of cell adhesion molecule production 3 3 1 1 0 1 0 0 162 3 2382 0.821 1.0 1.0 0.0 0 0 0 0 0 GO:0060456 6 positive regulation of digestive system process 3 4 2 2 1 1 0 0 162 4 2381 0.76872 1.0 1.0 0.0 0 0 0 0 0 GO:0060586 7 multicellular organismal iron ion homeostasis 3 3 1 1 1 0 0 0 162 3 2382 0.821 1.0 1.0 0.0 0 0 0 0 0 GO:0060620 9 regulation of cholesterol import 3 3 1 1 0 1 0 0 162 3 2382 0.821 1.0 1.0 0.0 0 0 0 0 0 GO:0060621 9 negative regulation of cholesterol import 2 2 1 1 0 1 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:0060644 6 mammary gland epithelial cell differentiation 4 5 1 1 1 0 0 0 162 5 2380 0.71975 1.0 1.0 0.0 0 0 0 0 0 GO:0060676 9 ureteric bud formation 3 3 1 1 0 1 0 0 162 3 2382 0.821 1.0 1.0 0.0 0 0 0 0 0 GO:0060694 6 regulation of cholesterol transporter activity 1 1 1 1 0 1 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0060695 7 negative regulation of cholesterol transporter activity 1 1 1 1 0 1 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0060759 5 regulation of response to cytokine stimulus 34 34 2 2 0 2 0 0 162 34 2351 0.10545 1.0 0.16633 0.0 0 0 0 0 0 GO:0060761 6 negative regulation of response to cytokine stimulus 14 14 2 2 0 2 0 0 162 14 2371 0.39753 1.0 1.0 0.0 0 0 0 0 0 GO:0060856 5 establishment of blood-brain barrier 4 4 1 1 1 0 0 0 162 4 2381 0.76872 1.0 1.0 0.0 0 0 0 0 0 GO:0061015 8 snRNA import into nucleus 1 1 1 1 0 1 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0061180 6 mammary gland epithelium development 2 2 1 1 1 0 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:0061365 8 positive regulation of triglyceride lipase activity 5 5 1 1 0 1 0 0 162 5 2380 0.71975 1.0 1.0 0.0 0 0 0 0 0 GO:0061402 9 positive regulation of transcription from RNA polymerase II promoter in response to acidic pH 2 2 1 1 0 1 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:0061458 5 reproductive system development 6 6 1 1 1 0 0 0 162 6 2379 0.67388 1.0 1.0 0.0 0 0 0 0 0 GO:0061515 5 myeloid cell development 17 18 1 1 0 1 0 0 162 18 2367 0.30513 1.0 0.62425 0.0 0 0 0 0 0 GO:0061869 8 regulation of hepatic stellate cell migration 1 1 1 1 1 0 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0061870 9 positive regulation of hepatic stellate cell migration 1 1 1 1 1 0 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0061873 7 regulation of hepatic stellate cell contraction 2 2 1 1 1 0 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:0061874 8 positive regulation of hepatic stellate cell contraction 1 1 1 1 1 0 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0061951 7 establishment of protein localization to plasma membrane 4 4 1 0 0 0 0 0 162 4 2381 0.76872 1.0 1.0 0.0 0 0 0 0 0 GO:0065004 7 protein-DNA complex assembly 28 35 1 1 0 1 0 0 162 35 2350 0.098656 1.0 0.16618 0.0 0 0 0 0 0 GO:0065005 7 protein-lipid complex assembly 7 7 2 2 0 2 0 0 162 7 2378 0.63092 1.0 1.0 0.0 0 0 0 0 0 GO:0070141 7 response to UV-A 3 3 1 1 0 1 0 0 162 3 2382 0.821 1.0 1.0 0.0 0 0 0 0 0 GO:0070227 7 lymphocyte apoptotic process 11 13 2 2 1 1 0 0 162 13 2372 0.42468 1.0 1.0 0.0 0 0 0 0 0 GO:0070228 9 regulation of lymphocyte apoptotic process 20 22 1 1 1 0 0 0 162 22 2363 0.23411 1.0 0.39477 0.0 0 0 0 0 0 GO:0070230 10 positive regulation of lymphocyte apoptotic process 7 7 1 1 1 0 0 0 162 7 2378 0.63092 1.0 1.0 0.0 0 0 0 0 0 GO:0070231 8 T cell apoptotic process 9 10 1 1 0 1 0 0 162 10 2375 0.51769 1.0 1.0 0.0 0 0 0 0 0 GO:0070254 5 mucus secretion 1 1 1 0 0 0 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0070303 7 negative regulation of stress-activated protein kinase signaling cascade 7 7 1 1 1 0 0 0 162 7 2378 0.63092 1.0 1.0 0.0 0 0 0 0 0 GO:0070509 10 calcium ion import 7 9 1 1 1 0 0 0 162 9 2376 0.55299 1.0 1.0 0.0 0 0 0 0 0 GO:0070525 7 tRNA threonylcarbamoyladenosine metabolic process 1 1 1 1 0 1 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0070541 6 response to platinum ion 3 3 1 1 0 1 0 0 162 3 2382 0.821 1.0 1.0 0.0 0 0 0 0 0 GO:0070570 7 regulation of neuron projection regeneration 7 8 1 1 0 0 0 0 162 8 2377 0.59068 1.0 1.0 0.0 0 0 0 0 0 GO:0070571 7 negative regulation of neuron projection regeneration 2 2 1 1 0 0 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:0070587 7 regulation of cell-cell adhesion involved in gastrulation 4 4 1 1 0 1 0 0 162 4 2381 0.76872 1.0 1.0 0.0 0 0 0 0 0 GO:0070875 7 positive regulation of glycogen metabolic process 6 6 1 1 1 0 0 0 162 6 2379 0.67388 1.0 1.0 0.0 0 0 0 0 0 GO:0070897 8 transcription preinitiation complex assembly 5 5 1 1 0 1 0 0 162 5 2380 0.71975 1.0 1.0 0.0 0 0 0 0 0 GO:0070900 8 mitochondrial tRNA modification 1 1 1 1 0 1 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0070901 8 mitochondrial tRNA methylation 1 1 1 1 0 1 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0070981 7 L-asparagine biosynthetic process 1 1 1 1 0 1 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0070982 7 L-asparagine metabolic process 1 1 1 1 0 1 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0071157 7 negative regulation of cell cycle arrest 7 8 1 1 0 1 0 0 162 8 2377 0.59068 1.0 1.0 0.0 0 0 0 0 0 GO:0071217 5 cellular response to external biotic stimulus 2 3 1 1 1 0 0 0 162 3 2382 0.821 1.0 1.0 0.0 0 0 0 0 0 GO:0071243 5 cellular response to arsenic-containing substance 6 6 2 2 2 0 0 0 162 6 2379 0.67388 1.0 1.0 0.0 0 0 0 0 0 GO:0071300 6 cellular response to retinoic acid 19 22 3 3 1 2 0 0 162 22 2363 0.23411 1.0 0.39477 0.0 0 0 0 0 0 GO:0071340 6 skeletal muscle acetylcholine-gated channel clustering 3 3 1 1 0 1 0 0 162 3 2382 0.821 1.0 1.0 0.0 0 0 0 0 0 GO:0071422 6 succinate transmembrane transport 2 2 1 0 0 1 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:0071462 5 cellular response to water stimulus 4 4 1 1 1 0 0 0 162 4 2381 0.76872 1.0 1.0 0.0 0 0 0 0 0 GO:0071464 5 cellular response to hydrostatic pressure 3 3 1 1 1 0 0 0 162 3 2382 0.821 1.0 1.0 0.0 0 0 0 0 0 GO:0071467 5 cellular response to pH 6 7 1 1 0 1 0 0 162 7 2378 0.63092 1.0 1.0 0.0 0 0 0 0 0 GO:0071468 6 cellular response to acidic pH 2 3 1 1 0 1 0 0 162 3 2382 0.821 1.0 1.0 0.0 0 0 0 0 0 GO:0071470 5 cellular response to osmotic stress 10 10 1 1 1 0 0 0 162 10 2375 0.51769 1.0 1.0 0.0 0 0 0 0 0 GO:0071472 6 cellular response to salt stress 1 1 1 1 1 0 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0071474 6 cellular hyperosmotic response 5 5 1 1 1 0 0 0 162 5 2380 0.71975 1.0 1.0 0.0 0 0 0 0 0 GO:0071475 7 cellular hyperosmotic salinity response 1 1 1 1 1 0 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0071679 6 commissural neuron axon guidance 5 5 1 1 0 1 0 0 162 5 2380 0.71975 1.0 1.0 0.0 0 0 0 0 0 GO:0071824 6 protein-DNA complex subunit organization 34 41 2 2 1 1 0 0 162 41 2344 0.066105 1.0 0.10857 0.0 0 0 0 0 0 GO:0071887 6 leukocyte apoptotic process 16 18 2 2 1 1 0 0 162 18 2367 0.30513 1.0 0.62425 0.0 0 0 0 0 0 GO:0071966 7 fungal-type cell wall polysaccharide metabolic process 1 1 1 1 1 0 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0072044 5 collecting duct development 4 4 1 1 0 0 0 0 162 4 2381 0.76872 1.0 1.0 0.0 0 0 0 0 0 GO:0072089 4 stem cell proliferation 7 8 1 1 1 0 0 0 162 8 2377 0.59068 1.0 1.0 0.0 0 0 0 0 0 GO:0072106 7 regulation of ureteric bud formation 4 4 1 1 0 1 0 0 162 4 2381 0.76872 1.0 1.0 0.0 0 0 0 0 0 GO:0072107 7 positive regulation of ureteric bud formation 4 4 1 1 0 1 0 0 162 4 2381 0.76872 1.0 1.0 0.0 0 0 0 0 0 GO:0072143 5 mesangial cell development 3 3 1 1 1 0 0 0 162 3 2382 0.821 1.0 1.0 0.0 0 0 0 0 0 GO:0072144 6 glomerular mesangial cell development 3 3 1 1 1 0 0 0 162 3 2382 0.821 1.0 1.0 0.0 0 0 0 0 0 GO:0072172 8 mesonephric tubule formation 4 4 1 1 0 1 0 0 162 4 2381 0.76872 1.0 1.0 0.0 0 0 0 0 0 GO:0072501 8 cellular divalent inorganic anion homeostasis 2 2 1 1 0 0 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:0072502 8 cellular trivalent inorganic anion homeostasis 2 2 1 1 0 0 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:0072505 8 divalent inorganic anion homeostasis 3 3 1 1 0 0 0 0 162 3 2382 0.821 1.0 1.0 0.0 0 0 0 0 0 GO:0072506 8 trivalent inorganic anion homeostasis 3 3 1 1 0 0 0 0 162 3 2382 0.821 1.0 1.0 0.0 0 0 0 0 0 GO:0072659 7 protein localization to plasma membrane 31 33 1 0 0 0 0 0 162 33 2352 0.11272 1.0 0.26691 0.0 0 0 0 0 0 GO:0072718 5 response to cisplatin 3 3 1 1 1 0 0 0 162 3 2382 0.821 1.0 1.0 0.0 0 0 0 0 0 GO:0072719 6 cellular response to cisplatin 3 3 1 1 1 0 0 0 162 3 2382 0.821 1.0 1.0 0.0 0 0 0 0 0 GO:0080154 5 regulation of fertilization 4 4 1 1 0 1 0 0 162 4 2381 0.76872 1.0 1.0 0.0 0 0 0 0 0 GO:0086097 7 phospholipase C-activating angiotensin-activated signaling pathway 1 1 1 1 0 1 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0090049 8 regulation of cell migration involved in sprouting angiogenesis 15 16 1 1 1 0 0 0 162 16 2369 0.3483 1.0 0.61907 0.0 0 0 0 0 0 GO:0090050 9 positive regulation of cell migration involved in sprouting angiogenesis 9 10 1 1 1 0 0 0 162 10 2375 0.51769 1.0 1.0 0.0 0 0 0 0 0 GO:0090095 7 regulation of metanephric cap mesenchymal cell proliferation 1 1 1 1 1 0 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0090096 7 positive regulation of metanephric cap mesenchymal cell proliferation 1 1 1 1 1 0 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0090130 3 tissue migration 4 4 1 1 1 0 0 0 162 4 2381 0.76872 1.0 1.0 0.0 0 0 0 0 0 GO:0090131 4 mesenchyme migration 4 4 1 1 1 0 0 0 162 4 2381 0.76872 1.0 1.0 0.0 0 0 0 0 0 GO:0090174 7 organelle membrane fusion 6 6 1 0 0 0 0 0 162 6 2379 0.67388 1.0 1.0 0.0 0 0 0 0 0 GO:0090186 5 regulation of pancreatic juice secretion 3 3 1 1 0 1 0 0 162 3 2382 0.821 1.0 1.0 0.0 0 0 0 0 0 GO:0090187 6 positive regulation of pancreatic juice secretion 2 2 1 1 0 1 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:0090279 9 regulation of calcium ion import 17 21 2 2 0 2 0 0 162 21 2364 0.25015 1.0 0.64016 0.0 0 0 0 0 0 GO:0090280 8 positive regulation of calcium ion import 10 12 1 1 0 1 0 0 162 12 2373 0.45368 1.0 1.0 0.0 0 0 0 0 0 GO:0090281 8 negative regulation of calcium ion import 4 5 1 1 0 1 0 0 162 5 2380 0.71975 1.0 1.0 0.0 0 0 0 0 0 GO:0090311 8 regulation of protein deacetylation 18 19 1 1 0 1 0 0 162 19 2366 0.28559 1.0 0.62863 0.0 0 0 0 0 0 GO:0090312 9 positive regulation of protein deacetylation 10 11 1 1 0 1 0 0 162 11 2374 0.48464 1.0 1.0 0.0 0 0 0 0 0 GO:0090342 5 regulation of cell aging 10 12 1 1 0 0 0 0 162 12 2373 0.45368 1.0 1.0 0.0 0 0 0 0 0 GO:0090344 6 negative regulation of cell aging 4 6 1 1 0 0 0 0 162 6 2379 0.67388 1.0 1.0 0.0 0 0 0 0 0 GO:0090596 5 sensory organ morphogenesis 17 17 1 1 0 1 0 0 162 17 2368 0.32601 1.0 0.62101 0.0 0 0 0 0 0 GO:0090646 9 mitochondrial tRNA processing 1 1 1 1 0 1 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0097035 5 regulation of membrane lipid distribution 9 9 1 1 1 0 0 0 162 9 2376 0.55299 1.0 1.0 0.0 0 0 0 0 0 GO:0097068 5 response to thyroxine 7 7 1 1 1 0 0 0 162 7 2378 0.63092 1.0 1.0 0.0 0 0 0 0 0 GO:0097267 7 omega-hydroxylase P450 pathway 2 2 1 1 0 1 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:0097325 5 melanocyte proliferation 1 1 1 1 0 1 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0097485 4 neuron projection guidance 40 45 1 1 0 1 0 0 162 45 2340 0.05059 1.0 0.11311 0.0 0 0 0 0 0 GO:0097696 6 receptor signaling pathway via STAT 9 9 1 1 1 0 0 0 162 9 2376 0.55299 1.0 1.0 0.0 0 0 0 0 0 GO:0097745 10 mitochondrial tRNA 5'-end processing 1 1 1 1 0 1 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0098693 6 regulation of synaptic vesicle cycle 19 25 1 0 0 0 0 0 162 25 2360 0.19186 1.0 0.40169 0.0 0 0 0 0 0 GO:0098781 8 ncRNA transcription 4 5 1 1 0 1 0 0 162 5 2380 0.71975 1.0 1.0 0.0 0 0 0 0 0 GO:0098801 6 regulation of renal system process 11 12 1 1 0 1 0 0 162 12 2373 0.45368 1.0 1.0 0.0 0 0 0 0 0 GO:0098876 5 vesicle-mediated transport to the plasma membrane 7 7 1 0 0 0 0 0 162 7 2378 0.63092 1.0 1.0 0.0 0 0 0 0 0 GO:0098967 6 exocytic insertion of neurotransmitter receptor to postsynaptic membrane 3 3 1 0 0 0 0 0 162 3 2382 0.821 1.0 1.0 0.0 0 0 0 0 0 GO:0099003 5 vesicle-mediated transport in synapse 19 21 1 0 0 0 0 0 162 21 2364 0.25015 1.0 0.64016 0.0 0 0 0 0 0 GO:0099039 7 sphingolipid translocation 2 2 1 1 1 0 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:0099040 8 ceramide translocation 2 2 1 1 1 0 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:0099072 4 regulation of postsynaptic membrane neurotransmitter receptor levels 12 12 1 0 0 0 0 0 162 12 2373 0.45368 1.0 1.0 0.0 0 0 0 0 0 GO:0099116 10 tRNA 5'-end processing 3 3 2 1 0 2 0 0 162 3 2382 0.821 1.0 1.0 0.0 0 0 0 0 0 GO:0099643 7 signal release from synapse 11 11 1 0 0 0 0 0 162 11 2374 0.48464 1.0 1.0 0.0 0 0 0 0 0 GO:0110112 5 regulation of lipid transporter activity 2 2 1 1 0 1 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:0110114 6 negative regulation of lipid transporter activity 1 1 1 1 0 1 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0110148 2 biomineralization 13 15 1 1 0 0 0 0 162 15 2370 0.37211 1.0 0.61863 0.0 0 0 0 0 0 GO:0120009 6 intermembrane lipid transfer 11 11 3 3 0 3 0 0 162 11 2374 0.48464 1.0 1.0 0.0 0 0 0 0 0 GO:0120163 5 negative regulation of cold-induced thermogenesis 12 14 1 1 0 1 0 0 162 14 2371 0.39753 1.0 1.0 0.0 0 0 0 0 0 GO:0140029 3 exocytic process 17 17 1 0 0 0 0 0 162 17 2368 0.32601 1.0 0.62101 0.0 0 0 0 0 0 GO:0140053 6 mitochondrial gene expression 4 4 1 1 0 1 0 0 162 4 2381 0.76872 1.0 1.0 0.0 0 0 0 0 0 GO:0140056 4 organelle localization by membrane tethering 10 10 1 0 0 0 0 0 162 10 2375 0.51769 1.0 1.0 0.0 0 0 0 0 0 GO:0140238 5 presynaptic endocytosis 9 11 1 0 0 0 0 0 162 11 2374 0.48464 1.0 1.0 0.0 0 0 0 0 0 GO:0150105 6 protein localization to cell-cell junction 6 6 1 1 1 0 0 0 162 6 2379 0.67388 1.0 1.0 0.0 0 0 0 0 0 GO:1900024 7 regulation of substrate adhesion-dependent cell spreading 16 18 1 1 0 1 0 0 162 18 2367 0.30513 1.0 0.62425 0.0 0 0 0 0 0 GO:1900026 8 positive regulation of substrate adhesion-dependent cell spreading 12 14 1 1 0 1 0 0 162 14 2371 0.39753 1.0 1.0 0.0 0 0 0 0 0 GO:1900087 9 positive regulation of G1/S transition of mitotic cell cycle 15 16 1 1 0 1 0 0 162 16 2369 0.3483 1.0 0.61907 0.0 0 0 0 0 0 GO:1900133 6 regulation of renin secretion into blood stream 2 2 1 1 0 1 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:1900135 6 positive regulation of renin secretion into blood stream 1 1 1 1 0 1 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:1900864 8 mitochondrial RNA modification 1 1 1 1 0 1 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:1901016 7 regulation of potassium ion transmembrane transporter activity 11 11 1 0 0 0 0 0 162 11 2374 0.48464 1.0 1.0 0.0 0 0 0 0 0 GO:1901068 8 guanosine-containing compound metabolic process 3 5 1 1 0 1 0 0 162 5 2380 0.71975 1.0 1.0 0.0 0 0 0 0 0 GO:1901099 7 negative regulation of signal transduction in absence of ligand 13 14 1 1 0 1 0 0 162 14 2371 0.39753 1.0 1.0 0.0 0 0 0 0 0 GO:1901136 5 carbohydrate derivative catabolic process 18 22 2 2 0 1 0 0 162 22 2363 0.23411 1.0 0.39477 0.0 0 0 0 0 0 GO:1901160 5 primary amino compound metabolic process 5 6 1 1 1 0 0 0 162 6 2379 0.67388 1.0 1.0 0.0 0 0 0 0 0 GO:1901379 8 regulation of potassium ion transmembrane transport 13 13 1 0 0 0 0 0 162 13 2372 0.42468 1.0 1.0 0.0 0 0 0 0 0 GO:1901529 7 positive regulation of anion channel activity 1 1 1 1 1 0 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:1901532 6 regulation of hematopoietic progenitor cell differentiation 8 8 1 1 0 0 0 0 162 8 2377 0.59068 1.0 1.0 0.0 0 0 0 0 0 GO:1901569 5 fatty acid derivative catabolic process 3 4 1 1 1 0 0 0 162 4 2381 0.76872 1.0 1.0 0.0 0 0 0 0 0 GO:1901570 5 fatty acid derivative biosynthetic process 18 23 6 6 2 4 0 0 162 23 2362 0.21909 1.0 0.39574 0.0 0 0 0 0 0 GO:1901656 7 glycoside transport 1 1 1 1 1 0 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:1901787 8 benzoyl-CoA metabolic process 1 1 1 1 0 1 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:1901989 8 positive regulation of cell cycle phase transition 34 37 1 1 0 1 0 0 162 37 2348 0.086339 1.0 0.16832 0.0 0 0 0 0 0 GO:1901992 8 positive regulation of mitotic cell cycle phase transition 30 32 1 1 0 1 0 0 162 32 2353 0.12048 1.0 0.2626 0.0 0 0 0 0 0 GO:1901998 5 toxin transport 11 11 1 1 0 1 0 0 162 11 2374 0.48464 1.0 1.0 0.0 0 0 0 0 0 GO:1902036 7 regulation of hematopoietic stem cell differentiation 3 3 1 1 0 0 0 0 162 3 2382 0.821 1.0 1.0 0.0 0 0 0 0 0 GO:1902065 5 response to L-glutamate 6 7 1 1 1 0 0 0 162 7 2378 0.63092 1.0 1.0 0.0 0 0 0 0 0 GO:1902224 5 ketone body metabolic process 3 3 2 2 1 1 0 0 162 3 2382 0.821 1.0 1.0 0.0 0 0 0 0 0 GO:1902259 8 regulation of delayed rectifier potassium channel activity 3 3 1 0 0 0 0 0 162 3 2382 0.821 1.0 1.0 0.0 0 0 0 0 0 GO:1902275 8 regulation of chromatin organization 37 37 1 1 0 1 0 0 162 37 2348 0.086339 1.0 0.16832 0.0 0 0 0 0 0 GO:1902396 7 protein localization to bicellular tight junction 4 4 1 1 1 0 0 0 162 4 2381 0.76872 1.0 1.0 0.0 0 0 0 0 0 GO:1902751 9 positive regulation of cell cycle G2/M phase transition 12 13 1 1 0 1 0 0 162 13 2372 0.42468 1.0 1.0 0.0 0 0 0 0 0 GO:1902808 9 positive regulation of cell cycle G1/S phase transition 17 18 1 1 0 1 0 0 162 18 2367 0.30513 1.0 0.62425 0.0 0 0 0 0 0 GO:1902905 7 positive regulation of supramolecular fiber organization 50 53 1 1 0 1 0 0 162 53 2332 0.029591 1.0 0.04668 0.0 0 0 0 0 0 GO:1902994 8 regulation of phospholipid efflux 2 2 1 1 0 1 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:1902995 8 positive regulation of phospholipid efflux 2 2 1 1 0 1 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:1903015 6 regulation of exo-alpha-sialidase activity 1 1 1 1 1 0 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:1903016 7 negative regulation of exo-alpha-sialidase activity 1 1 1 1 1 0 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:1903018 6 regulation of glycoprotein metabolic process 13 14 1 1 1 0 0 0 162 14 2371 0.39753 1.0 1.0 0.0 0 0 0 0 0 GO:1903019 7 negative regulation of glycoprotein metabolic process 4 4 1 1 1 0 0 0 162 4 2381 0.76872 1.0 1.0 0.0 0 0 0 0 0 GO:1903115 6 regulation of actin filament-based movement 7 7 1 1 1 0 0 0 162 7 2378 0.63092 1.0 1.0 0.0 0 0 0 0 0 GO:1903116 7 positive regulation of actin filament-based movement 2 2 1 1 1 0 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:1903305 7 regulation of regulated secretory pathway 36 42 2 1 1 0 0 0 162 42 2343 0.061832 1.0 0.10887 0.0 0 0 0 0 0 GO:1903306 8 negative regulation of regulated secretory pathway 6 6 1 1 1 0 0 0 162 6 2379 0.67388 1.0 1.0 0.0 0 0 0 0 0 GO:1903416 5 response to glycoside 6 6 1 1 1 0 0 0 162 6 2379 0.67388 1.0 1.0 0.0 0 0 0 0 0 GO:1903421 7 regulation of synaptic vesicle recycling 7 7 1 0 0 0 0 0 162 7 2378 0.63092 1.0 1.0 0.0 0 0 0 0 0 GO:1903556 7 negative regulation of tumor necrosis factor superfamily cytokine production 19 19 1 1 0 1 0 0 162 19 2366 0.28559 1.0 0.62863 0.0 0 0 0 0 0 GO:1903587 8 regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis 4 4 2 2 1 1 0 0 162 4 2381 0.76872 1.0 1.0 0.0 0 0 0 0 0 GO:1903589 9 positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis 4 4 2 2 1 1 0 0 162 4 2381 0.76872 1.0 1.0 0.0 0 0 0 0 0 GO:1903593 6 regulation of histamine secretion by mast cell 2 2 1 0 0 0 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:1903672 8 positive regulation of sprouting angiogenesis 16 17 2 2 1 1 0 0 162 17 2368 0.32601 1.0 0.62101 0.0 0 0 0 0 0 GO:1903793 7 positive regulation of anion transport 25 26 2 2 1 1 0 0 162 26 2359 0.17954 1.0 0.40644 0.0 0 0 0 0 0 GO:1903840 5 response to arsenite(3-) 1 1 1 1 1 0 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:1903841 6 cellular response to arsenite(3-) 1 1 1 1 1 0 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:1903842 5 response to arsenite ion 1 1 1 1 1 0 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:1903843 6 cellular response to arsenite ion 1 1 1 1 1 0 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:1903862 7 positive regulation of oxidative phosphorylation 4 4 1 1 1 0 0 0 162 4 2381 0.76872 1.0 1.0 0.0 0 0 0 0 0 GO:1903900 6 regulation of viral life cycle 36 38 2 2 2 0 0 0 162 38 2347 0.080767 1.0 0.17055 0.0 0 0 0 0 0 GO:1903901 6 negative regulation of viral life cycle 23 24 2 2 2 0 0 0 162 24 2361 0.20503 1.0 0.39808 0.0 0 0 0 0 0 GO:1903959 7 regulation of anion transmembrane transport 10 11 1 1 1 0 0 0 162 11 2374 0.48464 1.0 1.0 0.0 0 0 0 0 0 GO:1903961 8 positive regulation of anion transmembrane transport 5 5 1 1 1 0 0 0 162 5 2380 0.71975 1.0 1.0 0.0 0 0 0 0 0 GO:1903988 6 iron ion export across plasma membrane 1 1 1 1 1 0 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:1904386 6 response to L-phenylalanine derivative 7 7 1 1 1 0 0 0 162 7 2378 0.63092 1.0 1.0 0.0 0 0 0 0 0 GO:1904444 7 regulation of establishment of Sertoli cell barrier 2 2 1 1 1 0 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:1904446 8 positive regulation of establishment of Sertoli cell barrier 1 1 1 1 1 0 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:1904480 6 positive regulation of intestinal absorption 1 1 1 1 1 0 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:1904585 6 response to putrescine 1 1 1 1 1 0 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:1904586 6 cellular response to putrescine 1 1 1 1 1 0 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:1904619 5 response to dimethyl sulfoxide 1 1 1 1 1 0 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:1904620 6 cellular response to dimethyl sulfoxide 1 1 1 1 1 0 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:1904627 6 response to phorbol 13-acetate 12-myristate 3 3 1 1 1 0 0 0 162 3 2382 0.821 1.0 1.0 0.0 0 0 0 0 0 GO:1904628 6 cellular response to phorbol 13-acetate 12-myristate 3 3 1 1 1 0 0 0 162 3 2382 0.821 1.0 1.0 0.0 0 0 0 0 0 GO:1904729 7 regulation of intestinal lipid absorption 5 5 4 4 1 3 0 0 162 5 2380 0.71975 1.0 1.0 0.0 0 0 0 0 0 GO:1904730 7 negative regulation of intestinal lipid absorption 2 2 1 1 0 1 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:1904731 7 positive regulation of intestinal lipid absorption 1 1 1 1 1 0 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:1905114 6 cell surface receptor signaling pathway involved in cell-cell signaling 34 38 2 2 1 1 0 0 162 38 2347 0.080767 1.0 0.17055 0.0 0 0 0 0 0 GO:1905230 6 response to borneol 1 1 1 1 1 0 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:1905231 7 cellular response to borneol 1 1 1 1 1 0 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:1905232 6 cellular response to L-glutamate 2 2 1 1 1 0 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:1905233 5 response to codeine 1 1 1 1 1 0 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:1905235 5 response to quercetin 1 1 1 1 1 0 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:1905237 5 response to cyclosporin A 2 2 1 1 1 0 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:1905269 9 positive regulation of chromatin organization 25 25 1 1 0 1 0 0 162 25 2360 0.19186 1.0 0.40169 0.0 0 0 0 0 0 GO:1905276 6 regulation of epithelial tube formation 5 5 1 1 0 1 0 0 162 5 2380 0.71975 1.0 1.0 0.0 0 0 0 0 0 GO:1905278 6 positive regulation of epithelial tube formation 4 4 1 1 0 1 0 0 162 4 2381 0.76872 1.0 1.0 0.0 0 0 0 0 0 GO:1905395 5 response to flavonoid 4 4 1 1 1 0 0 0 162 4 2381 0.76872 1.0 1.0 0.0 0 0 0 0 0 GO:1905643 8 positive regulation of DNA methylation 1 1 1 1 1 0 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:1905664 6 regulation of calcium ion import across plasma membrane 3 3 1 1 0 1 0 0 162 3 2382 0.821 1.0 1.0 0.0 0 0 0 0 0 GO:1905665 11 positive regulation of calcium ion import across plasma membrane 2 2 1 1 0 1 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:1905939 5 regulation of gonad development 10 10 1 1 1 0 0 0 162 10 2375 0.51769 1.0 1.0 0.0 0 0 0 0 0 GO:1905941 6 positive regulation of gonad development 6 6 1 1 1 0 0 0 162 6 2379 0.67388 1.0 1.0 0.0 0 0 0 0 0 GO:1990180 10 mitochondrial tRNA 3'-end processing 1 1 1 1 0 1 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:1990646 7 cellular response to prolactin 3 3 1 1 1 0 0 0 162 3 2382 0.821 1.0 1.0 0.0 0 0 0 0 0 GO:1990778 6 protein localization to cell periphery 38 42 1 0 0 0 0 0 162 42 2343 0.061832 1.0 0.10887 0.0 0 0 0 0 0 GO:1990839 6 response to endothelin 3 3 1 1 1 0 0 0 162 3 2382 0.821 1.0 1.0 0.0 0 0 0 0 0 GO:1990840 4 response to lectin 1 1 1 1 1 0 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:1990858 5 cellular response to lectin 1 1 1 1 1 0 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:1990859 7 cellular response to endothelin 2 2 1 1 1 0 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:1990963 5 establishment of blood-retinal barrier 1 1 1 1 1 0 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:2000018 6 regulation of male gonad development 3 3 1 1 1 0 0 0 162 3 2382 0.821 1.0 1.0 0.0 0 0 0 0 0 GO:2000020 7 positive regulation of male gonad development 2 2 1 1 1 0 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:2000106 8 regulation of leukocyte apoptotic process 31 33 1 1 1 0 0 0 162 33 2352 0.11272 1.0 0.26691 0.0 0 0 0 0 0 GO:2000108 9 positive regulation of leukocyte apoptotic process 14 14 1 1 1 0 0 0 162 14 2371 0.39753 1.0 1.0 0.0 0 0 0 0 0 GO:2000124 7 regulation of endocannabinoid signaling pathway 2 2 1 1 0 1 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:2000243 5 positive regulation of reproductive process 28 28 1 1 1 0 0 0 162 28 2357 0.1572 1.0 0.25527 0.0 0 0 0 0 0 GO:2000489 6 regulation of hepatic stellate cell activation 4 5 1 1 1 0 0 0 162 5 2380 0.71975 1.0 1.0 0.0 0 0 0 0 0 GO:2000491 7 positive regulation of hepatic stellate cell activation 3 3 1 1 1 0 0 0 162 3 2382 0.821 1.0 1.0 0.0 0 0 0 0 0 GO:2000736 6 regulation of stem cell differentiation 14 14 1 1 0 0 0 0 162 14 2371 0.39753 1.0 1.0 0.0 0 0 0 0 0 GO:2000772 6 regulation of cellular senescence 9 10 1 1 0 0 0 0 162 10 2375 0.51769 1.0 1.0 0.0 0 0 0 0 0 GO:2000773 6 negative regulation of cellular senescence 3 4 1 1 0 0 0 0 162 4 2381 0.76872 1.0 1.0 0.0 0 0 0 0 0 GO:2000831 6 regulation of steroid hormone secretion 7 7 1 1 0 1 0 0 162 7 2378 0.63092 1.0 1.0 0.0 0 0 0 0 0 GO:2000846 7 regulation of corticosteroid hormone secretion 4 4 1 1 0 1 0 0 162 4 2381 0.76872 1.0 1.0 0.0 0 0 0 0 0 GO:2000855 8 regulation of mineralocorticoid secretion 3 3 1 1 0 1 0 0 162 3 2382 0.821 1.0 1.0 0.0 0 0 0 0 0 GO:2000858 9 regulation of aldosterone secretion 3 3 1 1 0 1 0 0 162 3 2382 0.821 1.0 1.0 0.0 0 0 0 0 0 GO:2000864 6 regulation of estradiol secretion 4 5 1 1 0 0 0 0 162 5 2380 0.71975 1.0 1.0 0.0 0 0 0 0 0 GO:2000866 7 positive regulation of estradiol secretion 3 4 1 1 0 0 0 0 162 4 2381 0.76872 1.0 1.0 0.0 0 0 0 0 0 GO:2000909 8 regulation of sterol import 3 3 1 1 0 1 0 0 162 3 2382 0.821 1.0 1.0 0.0 0 0 0 0 0 GO:2000910 8 negative regulation of sterol import 2 2 1 1 0 1 0 0 162 2 2383 0.87681 1.0 1.0 0.0 0 0 0 0 0 GO:2001138 7 regulation of phospholipid transport 4 4 1 1 0 1 0 0 162 4 2381 0.76872 1.0 1.0 0.0 0 0 0 0 0 GO:2001140 7 positive regulation of phospholipid transport 4 4 1 1 0 1 0 0 162 4 2381 0.76872 1.0 1.0 0.0 0 0 0 0 0 GO:2001225 8 regulation of chloride transport 1 1 1 1 1 0 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:2001239 8 regulation of extrinsic apoptotic signaling pathway in absence of ligand 18 19 1 1 0 1 0 0 162 19 2366 0.28559 1.0 0.62863 0.0 0 0 0 0 0 GO:2001240 8 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand 13 14 1 1 0 1 0 0 162 14 2371 0.39753 1.0 1.0 0.0 0 0 0 0 0 GO:2001256 9 regulation of store-operated calcium entry 4 4 1 1 0 1 0 0 162 4 2381 0.76872 1.0 1.0 0.0 0 0 0 0 0 GO:2001260 6 regulation of semaphorin-plexin signaling pathway 1 1 1 1 0 1 0 0 162 1 2384 0.9364 1.0 1.0 0.0 0 0 0 0 0 GO:0042770 6 signal transduction in response to DNA damage 22 24 4 4 4 3 3 3 159 21 2364 0.93819 0.19305 0.19305 12.5 25112;294515;114851 gadd45a;foxo3;cdkn1a GADD45A_8678;FOXO3_8662;CDKN1A_8271 40.78929 13.1992 6.24967 53.91798995064912 50.59352714394827 58.27959170687196 32.540616666666665 5.6804 2.44025 49.35590829131638 42.10559662406437 52.75768374272187 55.7519 32.7581 19.0606 52.14056720126854 63.877743301593775 57.563975541649775 0.5 9.724435 1.5 58.0591 102.919;13.1992;6.24967 89.5012;5.6804;2.44025 115.437;32.7581;19.0606 0 3 0 3 25112;294515;114851 GADD45A_8678;FOXO3_8662;CDKN1A_8271 40.78929 13.1992 53.91798995064912 32.540616666666665 5.6804 49.35590829131638 55.7519 32.7581 52.14056720126854 102.919;13.1992;6.24967 89.5012;5.6804;2.44025 115.437;32.7581;19.0606 0 Exp 4,2(0.67);Poly 2,1(0.34) 1.7036977955898407 5.1444090604782104 1.522104263305664 1.9883413314819336 0.24340403881290731 1.6339634656906128 -20.224659383854778 101.80323938385479 -23.310851331989724 88.39208466532305 -3.250706198330235 114.75450619833023 DOWN 0.0 1.0 0.0 GO:0071900 8 regulation of protein serine/threonine kinase activity 142 154 10 10 9 10 9 9 153 145 2240 0.47747 0.65712 1.0 5.84 246273;24825;24471;25675;29455;299626;25112;116663;114851 trib3;tf;hspb1;hmgcr;gdf15;gadd45b;gadd45a;dusp6;cdkn1a TRIB3_10079;TF_10003;HSPB1_8847;HMGCR_8810;GDF15_33113;GADD45B_8679;GADD45A_8678;DUSP6_8506;CDKN1A_8271 69.66977333333334 89.1011 1.63089 43.11038005431319 70.75154739041231 40.989119336972536 49.12178744444444 52.7132 0.663137 34.20229969230623 52.49498831252713 34.85706584361938 91.2907 109.434 7.6286 49.873301208813125 92.30288919905307 46.12900498283199 6.5 105.75800000000001 108.064;45.1539;89.1011;1.63089;105.149;106.367;102.919;62.3934;6.24967 83.8836;28.132;60.3265;0.663137;85.3487;52.7132;89.5012;39.0875;2.44025 143.428;61.5341;106.138;7.6286;125.652;109.434;115.437;133.304;19.0606 2 7 2 24825;299626 TF_10003;GADD45B_8679 75.76045 75.76045 43.28419810745022 40.4226 40.4226 17.38153320970276 85.48405 85.48405 33.8703441081575 45.1539;106.367 28.132;52.7132 61.5341;109.434 7 246273;24471;25675;29455;25112;116663;114851 TRIB3_10079;HSPB1_8847;HMGCR_8810;GDF15_33113;GADD45A_8678;DUSP6_8506;CDKN1A_8271 67.92958 89.1011 46.36652267034229 51.60726957142857 60.3265 38.431032736159516 92.94974285714285 115.437 55.77464753639887 108.064;89.1011;1.63089;105.149;102.919;62.3934;6.24967 83.8836;60.3265;0.663137;85.3487;89.5012;39.0875;2.44025 143.428;106.138;7.6286;125.652;115.437;133.304;19.0606 0 Exp 2,1(0.12);Exp 4,2(0.23);Poly 2,5(0.56);Power,1(0.12) 1.6851333347313746 15.215802907943726 1.522104263305664 1.9017701148986816 0.14605315874039768 1.6357084512710571 41.50432503118205 97.83522163548463 26.776284978804366 71.4672899100845 58.70680987690877 123.87459012309125 DOWN 0.2222222222222222 0.7777777777777778 0.0 GO:0060395 5 SMAD protein signal transduction 24 24 4 4 4 4 4 4 158 20 2365 0.98452 0.061808 0.061808 16.67 24825;24516;29455;314322 tf;jun;gdf15;fos TF_10003;JUN_8938;GDF15_33113;FOS_8657 41.683825000000326 30.79315 1.28141E-12 46.24228075923372 55.78755647991242 45.46920828222486 31.000775000000317 19.3272 1.28141E-12 38.045318218529076 41.81251881168393 38.634288530070016 56.77877500000032 50.73155 1.28142E-12 52.51627825670613 72.90684420795549 49.8346572200788 0.5 8.216200000000642 1.5 30.79315 45.1539;16.4324;105.149;1.28141E-12 28.132;10.5224;85.3487;1.28141E-12 61.5341;39.929;125.652;1.28142E-12 1 3 1 24825 TF_10003 45.1539 45.1539 28.132 28.132 61.5341 61.5341 45.1539 28.132 61.5341 3 24516;29455;314322 JUN_8938;GDF15_33113;FOS_8657 40.52713333333376 16.4324 56.56408030767655 31.957033333333758 10.5224 46.536896947726234 55.19366666666709 39.929 64.20174306304513 16.4324;105.149;1.28141E-12 10.5224;85.3487;1.28141E-12 39.929;125.652;1.28142E-12 0 Hill,1(0.25);Poly 2,3(0.75) 1.8104396001591943 7.270263075828552 1.5606178045272827 1.9785058498382568 0.18116930796738032 1.8655697107315063 -3.633610144048731 87.00126014404938 -6.283636854158164 68.28518685415881 5.312822308428316 108.24472769157234 DOWN 0.25 0.75 0.0 GO:0070848 5 response to growth factor 153 159 14 14 14 12 12 12 150 147 2238 0.79312 0.30899 0.50172 7.55 79426;83516;25513;25591;494344;24471;294515;25661;24330;116663;497840;192272 zfp36;ppargc1a;pik3r1;parp1;ier2;hspb1;foxo3;fn1;egr1;dusp6;cps1;acot2 ZFP36_10204;PPARGC1A_33189;PIK3R1_32562;PARP1_9425;IER2_32643;HSPB1_8847;FOXO3_8662;FN1_8655;EGR1_8533;DUSP6_8506;CPS1_32421;ACOT2_7969 33.641541749999995 29.47835 0.348134 27.661236255865404 41.31379150635217 27.19806381516259 21.779940083333333 23.1413 0.118102 17.952314872474815 26.567451686322453 17.38040195774621 57.27954166666667 43.593450000000004 1.15962 44.392663736869 68.3004914741838 42.47968560140121 6.5 37.196 0.348134;42.4094;18.7324;26.9741;49.6814;89.1011;13.1992;59.5777;0.750017;62.3934;31.9826;8.54905 0.118102;26.2988;11.6701;21.799;33.4626;60.3265;5.6804;31.0499;0.186019;39.0875;24.4836;7.19676 1.15962;81.7305;41.5978;35.2797;89.4404;106.138;32.7581;105.243;4.70178;133.304;45.5891;10.4125 2 10 2 25591;192272 PARP1_9425;ACOT2_7969 17.761575 17.761575 13.028477798701193 14.49788 14.49788 10.325342924513448 22.8461 22.8461 17.583765749122115 26.9741;8.54905 21.799;7.19676 35.2797;10.4125 10 79426;83516;25513;494344;24471;294515;25661;24330;116663;497840 ZFP36_10204;PPARGC1A_33189;PIK3R1_32562;IER2_32643;HSPB1_8847;FOXO3_8662;FN1_8655;EGR1_8533;DUSP6_8506;CPS1_32421 36.8175351 37.196 29.13879934216181 23.2363521 25.391199999999998 19.181185335400997 64.16623 63.659800000000004 45.366430491981134 0.348134;42.4094;18.7324;49.6814;89.1011;13.1992;59.5777;0.750017;62.3934;31.9826 0.118102;26.2988;11.6701;33.4626;60.3265;5.6804;31.0499;0.186019;39.0875;24.4836 1.15962;81.7305;41.5978;89.4404;106.138;32.7581;105.243;4.70178;133.304;45.5891 0 Exp 2,5(0.42);Exp 4,1(0.09);Hill,2(0.17);Linear,1(0.09);Poly 2,2(0.17);Power,1(0.09) 2.2439538777891546 33.924254298210144 1.6357084512710571 11.836054801940918 2.9236582989926103 1.7939516305923462 17.990723995527112 49.29235950447289 11.622461735617078 31.937418431049586 32.162027635311325 82.397055698022 DOWN 0.16666666666666666 0.8333333333333334 0.0 GO:0071549 7 cellular response to dexamethasone stimulus 35 36 10 10 7 8 5 5 157 31 2354 0.97612 0.07456 0.07456 13.89 116636;140942;25698;312382;25303 eif4ebp1;ddit4;ass1;abcg2;abcc2 EIF4EBP1_8550;DDIT4_8450;ASS1_33159;ABCG2_32656;ABCC2_32541 49.938808 46.2316 5.21654 35.76462914646705 41.52570871621102 36.55116067575194 30.111756000000003 31.1788 2.73368 19.497805962176354 24.433552291875248 19.340546526854983 96.53817999999998 81.7848 11.386 91.31221521254427 68.25683400847132 70.32421408288855 0.5 16.01012 2.5 65.06585 83.9001;87.5421;26.8037;5.21654;46.2316 42.4185;53.2453;20.9825;2.73368;31.1788 107.32;245.492;36.7081;11.386;81.7848 2 3 2 116636;312382 EIF4EBP1_8550;ABCG2_32656 44.558319999999995 44.558319999999995 55.637678843898584 22.57609 22.57609 28.061405332167524 59.352999999999994 59.352999999999994 67.83558194635026 83.9001;5.21654 42.4185;2.73368 107.32;11.386 3 140942;25698;25303 DDIT4_8450;ASS1_33159;ABCC2_32541 53.525800000000004 46.2316 31.019225068818212 35.135533333333335 31.1788 16.491327113465832 121.3283 81.7848 109.86557931850173 87.5421;26.8037;46.2316 53.2453;20.9825;31.1788 245.492;36.7081;81.7848 0 Exp 2,2(0.4);Exp 3,1(0.2);Exp 4,1(0.2);Linear,1(0.2) 1.7119442905564002 8.58790135383606 1.5074360370635986 1.8814297914505005 0.15454308946458498 1.672852873802185 18.589728351064327 81.28788764893568 13.021175538937403 47.2023364610626 16.49949440659499 176.57686559340505 DOWN 0.4 0.6 0.0 GO:0001561 7 fatty acid alpha-oxidation 2 2 2 2 2 2 2 2 160 0 2385 1.0 0.0040221 0.0040221 100.0 65192;85255 slc27a2;hacl1 SLC27A2_9860;HACL1_8775 12.624695000000001 12.624695000000001 7.62189 7.075034680907932 10.885219908827187 6.633593939217919 8.34708 8.34708 5.49916 4.027567088553587 7.356858334024038 3.776270482534792 25.522949999999998 25.522949999999998 13.3925 17.15504690768872 21.30519303771239 16.084672418770264 0.0 7.62189 0.0 7.62189 7.62189;17.6275 5.49916;11.195 13.3925;37.6534 2 0 2 65192;85255 SLC27A2_9860;HACL1_8775 12.624695000000001 12.624695000000001 7.075034680907932 8.34708 8.34708 4.027567088553587 25.522949999999998 25.522949999999998 17.15504690768872 7.62189;17.6275 5.49916;11.195 13.3925;37.6534 0 0 Hill,1(0.5);Poly 2,1(0.5) 1.937377750428508 3.9027563333511353 1.7180453538894653 2.18471097946167 0.3299824283887682 1.9513781666755676 2.8191971999999996 22.4301928 2.7651567999999997 13.9290032 1.7472680000000054 49.298632 UP 1.0 0.0 0.0 GO:0097089 7 methyl-branched fatty acid metabolic process 2 2 2 2 2 2 2 2 160 0 2385 1.0 0.0040221 0.0040221 100.0 65192;85255 slc27a2;hacl1 SLC27A2_9860;HACL1_8775 12.624695000000001 12.624695000000001 7.62189 7.075034680907932 10.885219908827187 6.633593939217919 8.34708 8.34708 5.49916 4.027567088553587 7.356858334024038 3.776270482534792 25.522949999999998 25.522949999999998 13.3925 17.15504690768872 21.30519303771239 16.084672418770264 0.0 7.62189 0.0 7.62189 7.62189;17.6275 5.49916;11.195 13.3925;37.6534 2 0 2 65192;85255 SLC27A2_9860;HACL1_8775 12.624695000000001 12.624695000000001 7.075034680907932 8.34708 8.34708 4.027567088553587 25.522949999999998 25.522949999999998 17.15504690768872 7.62189;17.6275 5.49916;11.195 13.3925;37.6534 0 0 Hill,1(0.5);Poly 2,1(0.5) 1.937377750428508 3.9027563333511353 1.7180453538894653 2.18471097946167 0.3299824283887682 1.9513781666755676 2.8191971999999996 22.4301928 2.7651567999999997 13.9290032 1.7472680000000054 49.298632 UP 1.0 0.0 0.0 GO:0022603 5 regulation of anatomical structure morphogenesis 271 280 20 20 15 17 13 13 149 267 2118 0.12961 0.92083 0.24347 4.64 24794;83516;29441;81819;24471;24957;29455;25112;25661;24890;113936;29184;155423 serpina3c;ppargc1a;por;pax8;hspb1;glul;gdf15;gadd45a;fn1;esr1;cpb2;cd36;anxa7 SERPINA3C_32925;PPARGC1A_33189;POR_9531;PAX8_9432;HSPB1_8847;GLUL_32832;GDF15_33113;GADD45A_8678;FN1_8655;ESR1_33192;CPB2_8369;CD36_8243;ANXA7_8051 55.90169230769231 48.1296 12.4414 33.87418145058913 63.4834629655657 32.306702371059075 39.28758538461539 31.0499 8.48981 25.350174388159736 45.10620008602066 26.310344651477763 78.13935384615385 81.5688 31.9156 33.464083587696784 89.0245390385466 27.961656734362926 29.766;42.4094;12.4414;56.8931;89.1011;26.4669;105.149;102.919;59.5777;23.3972;25.8316;48.1296;104.64 23.347;26.2988;8.48981;45.1162;60.3265;21.0456;85.3487;89.5012;31.0499;18.3088;20.4374;37.5433;43.9254 40.8256;81.7305;79.2355;81.5688;106.138;35.4303;125.652;115.437;105.243;31.9156;34.8042;69.1421;108.689 3 10 3 81819;29184;155423 PAX8_9432;CD36_8243;ANXA7_8051 69.88756666666667 56.8931 30.413787169692206 42.194966666666666 43.9254 4.072223378368778 86.46663333333333 81.5688 20.22327627817345 56.8931;48.1296;104.64 45.1162;37.5433;43.9254 81.5688;69.1421;108.689 10 24794;83516;29441;24471;24957;29455;25112;25661;24890;113936 SERPINA3C_32925;PPARGC1A_33189;POR_9531;HSPB1_8847;GLUL_32832;GDF15_33113;GADD45A_8678;FN1_8655;ESR1_33192;CPB2_8369 51.70593 36.0877 35.208374744245475 38.415371 24.8229 29.146076378876437 75.64117000000002 80.483 37.043123370323386 29.766;42.4094;12.4414;89.1011;26.4669;105.149;102.919;59.5777;23.3972;25.8316 23.347;26.2988;8.48981;60.3265;21.0456;85.3487;89.5012;31.0499;18.3088;20.4374 40.8256;81.7305;79.2355;106.138;35.4303;125.652;115.437;105.243;31.9156;34.8042 0 Exp 2,5(0.39);Exp 3,1(0.08);Linear,2(0.16);Poly 2,4(0.31);Power,1(0.08) 1.8429538681087743 24.3619145154953 1.5461770296096802 2.6703107357025146 0.3757287927784067 1.7521979808807373 37.48747751203372 74.3159071033509 25.507073611308517 53.06809715792225 59.9480707882128 96.33063690409487 DOWN 0.23076923076923078 0.7692307692307693 0.0 GO:2001242 7 regulation of intrinsic apoptotic signaling pathway 62 64 4 4 3 4 3 3 159 61 2324 0.41048 0.78528 0.79584 4.69 25591;192235;24471 parp1;hyou1;hspb1 PARP1_9425;HYOU1_8857;HSPB1_8847 52.09113333333334 40.1982 26.9741 32.72647903003519 53.517202419354845 35.3300387370808 37.16996666666667 29.3844 21.799 20.40963866175326 38.152536961425675 21.971844930073523 67.92493333333333 62.3571 35.2797 35.75577220174855 67.63729674035642 39.49322652886723 26.9741;40.1982;89.1011 21.799;29.3844;60.3265 35.2797;62.3571;106.138 1 2 1 25591 PARP1_9425 26.9741 26.9741 21.799 21.799 35.2797 35.2797 26.9741 21.799 35.2797 2 192235;24471 HYOU1_8857;HSPB1_8847 64.64965000000001 64.64965000000001 34.57957220968759 44.855450000000005 44.855450000000005 21.879368734152266 84.24755 84.24755 30.957771276450114 40.1982;89.1011 29.3844;60.3265 62.3571;106.138 0 Exp 2,2(0.67);Poly 2,1(0.34) 1.7181147560097338 5.158078908920288 1.6520916223526 1.8086696863174438 0.08058263487800782 1.6973176002502441 15.057636037199181 89.12463062946748 14.074286330831235 60.2656470025021 27.46346811003891 108.38639855662774 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0051048 6 negative regulation of secretion 62 66 10 10 8 7 5 5 157 61 2324 0.75984 0.41133 0.60862 7.58 25591;25675;113965;25661;29496 parp1;hmgcr;hadh;fn1;erbb3 PARP1_9425;HMGCR_8810;HADH_8776;FN1_8655;ERBB3_8571 36.498718000000004 33.3125 1.63089 24.746260277486776 44.13160045358123 19.00654871109332 24.1698474 25.7336 0.663137 15.09886193488052 28.602018204454705 9.666607636277858 61.821780000000004 46.9856 7.6286 46.006909259827474 73.70841807149986 40.117878080715855 2.5 46.4451 26.9741;1.63089;33.3125;59.5777;60.9984 21.799;0.663137;25.7336;31.0499;41.6036 35.2797;7.6286;46.9856;105.243;113.972 3 2 3 25591;113965;29496 PARP1_9425;HADH_8776;ERBB3_8571 40.428333333333335 33.3125 18.09390949030456 29.71206666666667 25.7336 10.484593127696138 65.41243333333334 46.9856 42.45916461546708 26.9741;33.3125;60.9984 21.799;25.7336;41.6036 35.2797;46.9856;113.972 2 25675;25661 HMGCR_8810;FN1_8655 30.604295 30.604295 40.97458229912844 15.8565185 15.8565185 21.48668617560848 56.4358 56.4358 69.02380418145611 1.63089;59.5777 0.663137;31.0499 7.6286;105.243 0 Exp 2,1(0.2);Exp 4,1(0.2);Linear,2(0.4);Power,1(0.2) 1.8066745140564902 9.055131793022156 1.6013026237487793 1.9641557931900024 0.138458868447202 1.8086696863174438 14.807664493609611 58.189771506390386 10.93511138564348 37.40458341435652 21.49494599646159 102.1486140035384 UP 0.6 0.4 0.0 GO:0055076 9 transition metal ion homeostasis 23 26 7 7 6 4 3 3 159 23 2362 0.92111 0.2269 0.2269 11.54 24825;24567;304929 tf;mt1;f5 TF_10003;MT1A_9255;F5_33079 22.8981 12.9315 10.6089 19.30904174007608 33.14611689677242 19.608967865887333 13.211206666666667 8.91033 2.59129 13.30244796653734 20.132215567340218 13.255911716926759 40.83516666666667 37.5078 23.4636 19.252123759817596 50.194434643869435 19.204997308036926 0.5 11.770199999999999 1.5 29.0427 45.1539;12.9315;10.6089 28.132;8.91033;2.59129 61.5341;23.4636;37.5078 1 2 1 24825 TF_10003 45.1539 45.1539 28.132 28.132 61.5341 61.5341 45.1539 28.132 61.5341 2 24567;304929 MT1A_9255;F5_33079 11.770199999999999 11.770199999999999 1.6423262099838911 5.7508099999999995 5.7508099999999995 4.468236034589043 30.4857 30.4857 9.93074905634012 12.9315;10.6089 8.91033;2.59129 23.4636;37.5078 0 Hill,1(0.34);Poly 2,2(0.67) 1.922666173154879 5.812084197998047 1.7042291164398193 2.273383855819702 0.2982013920261312 1.8344712257385254 1.0478623250037842 44.748337674996215 -1.8419302854815243 28.264343618814856 19.04933774966942 62.62099558366393 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0010952 7 positive regulation of peptidase activity 63 67 5 5 4 3 2 2 160 65 2320 0.18903 0.93452 0.44002 2.99 63868;25661 hspd1;fn1 HSPD1_8849;FN1_8655 50.9178 50.9178 42.2579 12.246948028794758 52.97408122586271 11.896686558043351 27.4984 27.4984 23.9469 5.022579466768044 28.341698741746608 4.878934203731103 103.81299999999999 103.81299999999999 102.383 2.0223253941939117 104.15255151364146 1.9644870931533334 42.2579;59.5777 23.9469;31.0499 102.383;105.243 1 1 1 63868 HSPD1_8849 42.2579 42.2579 23.9469 23.9469 102.383 102.383 42.2579 23.9469 102.383 1 25661 FN1_8655 59.5777 59.5777 31.0499 31.0499 105.243 105.243 59.5777 31.0499 105.243 0 Exp 3,1(0.5);Power,1(0.5) 2.0016413769755745 4.031084179878235 1.7792335748672485 2.2518506050109863 0.3341907069188839 2.0155420899391174 33.944396 67.891204 20.53746 34.45934 101.01019999999998 106.6158 CONFLICT 0.5 0.5 0.0 GO:0017148 8 negative regulation of translation 21 22 2 2 2 2 2 2 160 20 2365 0.83934 0.41295 0.64706 9.09 79426;116636 zfp36;eif4ebp1 ZFP36_10204;EIF4EBP1_8550 42.124117 42.124117 0.348134 59.08016174006785 61.97842682257697 51.981518582769624 21.268301 21.268301 0.118102 29.910898272689877 31.320071744811862 26.317021968047424 54.23981 54.23981 1.15962 75.06672459134073 79.46651831470923 66.04725214633352 0.5 42.124117 0.348134;83.9001 0.118102;42.4185 1.15962;107.32 1 1 1 116636 EIF4EBP1_8550 83.9001 83.9001 42.4185 42.4185 107.32 107.32 83.9001 42.4185 107.32 1 79426 ZFP36_10204 0.348134 0.348134 0.118102 0.118102 1.15962 1.15962 0.348134 0.118102 1.15962 0 Exp 3,1(0.5);Hill,1(0.5) 1.8006343741127846 3.6110293865203857 1.672852873802185 1.9381765127182007 0.1876121442866056 1.8055146932601929 -39.75680967999999 124.00504367999999 -20.18608904 62.72269104 -49.7973624 158.27698239999998 CONFLICT 0.5 0.5 0.0 GO:0043627 3 response to estrogen 45 49 10 10 6 7 3 3 159 46 2339 0.62022 0.6126 1.0 6.12 63868;24890;25303 hspd1;esr1;abcc2 HSPD1_8849;ESR1_33192;ABCC2_32541 37.295566666666666 42.2579 23.3972 12.199222103205315 40.7641080296373 9.118383157172737 24.478166666666667 23.9469 18.3088 6.451426834688061 25.46452069440855 5.3926832010144885 72.0278 81.7848 31.9156 36.2327600720674 85.28318661152753 29.464088029588083 1.5 44.244749999999996 42.2579;23.3972;46.2316 23.9469;18.3088;31.1788 102.383;31.9156;81.7848 1 2 1 63868 HSPD1_8849 42.2579 42.2579 23.9469 23.9469 102.383 102.383 42.2579 23.9469 102.383 2 24890;25303 ESR1_33192;ABCC2_32541 34.8144 34.8144 16.14635908432611 24.7438 24.7438 9.100464273870866 56.8502 56.8502 35.26284949234818 23.3972;46.2316 18.3088;31.1788 31.9156;81.7848 0 Exp 2,2(0.67);Exp 3,1(0.34) 2.168809330450964 6.547802925109863 1.8589661121368408 2.436986207962036 0.29516680238999077 2.2518506050109863 23.490847302895 51.10028603043833 17.177689948124577 31.778643385208756 31.0265721890612 113.0290278109388 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0006730 4 one-carbon metabolic process 9 10 2 2 1 2 1 1 161 9 2376 0.87066 0.48231 0.48231 10.0 54232 car3 CAR3_8196 53.9626 53.9626 53.9626 53.9626 28.5034 28.5034 28.5034 28.5034 77.0288 77.0288 77.0288 77.0288 0.0 53.9626 0.0 53.9626 53.9626 28.5034 77.0288 0 1 0 1 54232 CAR3_8196 53.9626 53.9626 28.5034 28.5034 77.0288 77.0288 53.9626 28.5034 77.0288 0 Poly 2,1(1) 3.910295248031616 3.910295248031616 3.910295248031616 3.910295248031616 0.0 3.910295248031616 53.9626 53.9626 28.5034 28.5034 77.0288 77.0288 DOWN 0.0 1.0 0.0 GO:0007623 3 circadian rhythm 58 63 9 9 8 6 6 6 156 57 2328 0.89816 0.2086 0.29004 9.52 83516;24516;29496;24330;79431;25698 ppargc1a;jun;erbb3;egr1;bhlhe40;ass1 PPARGC1A_33189;JUN_8938;ERBB3_8571;EGR1_8533;BHLHE40_8141;ASS1_33159 34.200402833333335 34.60655 0.750017 23.8000167577531 32.13148909449305 24.23555450577336 22.990403166666667 23.64065 0.186019 15.954992132201767 21.71384100576428 16.323899959350797 64.60356333333333 60.829750000000004 4.70178 44.31618626155534 59.93569835855206 45.08155339430445 2.5 34.60655 42.4094;16.4324;60.9984;0.750017;57.8085;26.8037 26.2988;10.5224;41.6036;0.186019;38.3491;20.9825 81.7305;39.929;113.972;4.70178;110.58;36.7081 1 5 1 29496 ERBB3_8571 60.9984 60.9984 41.6036 41.6036 113.972 113.972 60.9984 41.6036 113.972 5 83516;24516;24330;79431;25698 PPARGC1A_33189;JUN_8938;EGR1_8533;BHLHE40_8141;ASS1_33159 28.8408034 26.8037 22.19484628113603 19.2677638 20.9825 14.637858057665142 54.729876000000004 39.929 41.51785994349757 42.4094;16.4324;0.750017;57.8085;26.8037 26.2988;10.5224;0.186019;38.3491;20.9825 81.7305;39.929;4.70178;110.58;36.7081 0 Exp 2,3(0.5);Hill,1(0.17);Linear,1(0.17);Poly 2,1(0.17) 2.0549118133976614 13.140868544578552 1.6013026237487793 4.21828556060791 1.002384016693298 1.8195264339447021 15.15642317077991 53.24438249588676 10.223750572488587 35.75705576084475 29.143229062263444 100.06389760440321 DOWN 0.16666666666666666 0.8333333333333334 0.0 GO:0061041 7 regulation of wound healing 71 74 8 8 8 7 7 7 155 67 2318 0.9055 0.1876 0.232 9.46 85253;288001;25675;361969;113936;114851;29184 plg;kng1;hmgcr;fga;cpb2;cdkn1a;cd36 PLG_9501;KNG1L1_34113;HMGCR_8810;FGA_8632;CPB2_8369;CDKN1A_8271;CD36_8243 29.367608571428573 25.8316 1.63089 23.837573850326038 35.50774235609731 25.184018612622328 21.340955285714283 20.4374 0.663137 16.696040694354622 25.354428597228736 17.686456637230574 50.31604285714286 34.8042 7.6286 48.14628523547991 62.836773219773924 51.930435834099576 2.5 25.098550000000003 70.7857;24.3655;1.63089;28.5803;25.8316;6.24967;48.1296 46.2356;19.538;0.663137;22.529;20.4374;2.44025;37.5433 150.579;32.1467;7.6286;38.8511;34.8042;19.0606;69.1421 1 6 1 29184 CD36_8243 48.1296 48.1296 37.5433 37.5433 69.1421 69.1421 48.1296 37.5433 69.1421 6 85253;288001;25675;361969;113936;114851 PLG_9501;KNG1L1_34113;HMGCR_8810;FGA_8632;CPB2_8369;CDKN1A_8271 26.240610000000004 25.098550000000003 24.489583580201604 18.6405645 19.9877 16.53044471628823 47.17836666666667 33.47545 51.95170486721939 70.7857;24.3655;1.63089;28.5803;25.8316;6.24967 46.2356;19.538;0.663137;22.529;20.4374;2.44025 150.579;32.1467;7.6286;38.8511;34.8042;19.0606 0 Exp 2,2(0.29);Exp 4,2(0.29);Linear,3(0.43) 1.825851115152568 13.105047464370728 1.522104263305664 2.6703107357025146 0.47321178220316074 1.5630855560302734 11.708486736640825 47.02673040621633 8.972355249844865 33.7095553215837 14.648775617437863 85.98331009684786 DOWN 0.14285714285714285 0.8571428571428571 0.0 GO:1903381 8 regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway 1 1 1 1 1 1 1 1 161 0 2385 1.0 0.063604 0.063604 100.0 192235 hyou1 HYOU1_8857 40.1982 40.1982 40.1982 40.1982 29.3844 29.3844 29.3844 29.384400000000003 62.3571 62.3571 62.3571 62.3571 0.0 40.1982 0.0 40.1982 40.1982 29.3844 62.3571 0 1 0 1 192235 HYOU1_8857 40.1982 40.1982 29.3844 29.3844 62.3571 62.3571 40.1982 29.3844 62.3571 0 Exp 2,1(1) 1.6520916223526 1.6520916223526 1.6520916223526 1.6520916223526 0.0 1.6520916223526 40.1982 40.1982 29.3844 29.3844 62.3571 62.3571 DOWN 0.0 1.0 0.0 GO:1903382 8 negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway 1 1 1 1 1 1 1 1 161 0 2385 1.0 0.063604 0.063604 100.0 192235 hyou1 HYOU1_8857 40.1982 40.1982 40.1982 40.1982 29.3844 29.3844 29.3844 29.384400000000003 62.3571 62.3571 62.3571 62.3571 0.0 40.1982 0.0 40.1982 40.1982 29.3844 62.3571 0 1 0 1 192235 HYOU1_8857 40.1982 40.1982 29.3844 29.3844 62.3571 62.3571 40.1982 29.3844 62.3571 0 Exp 2,1(1) 1.6520916223526 1.6520916223526 1.6520916223526 1.6520916223526 0.0 1.6520916223526 40.1982 40.1982 29.3844 29.3844 62.3571 62.3571 DOWN 0.0 1.0 0.0 GO:0019219 6 regulation of nucleobase-containing compound metabolic process 550 589 41 41 32 34 28 28 134 561 1824 0.039154 0.97535 0.082457 4.75 79426;24522;246273;24825;293615;25106;83516;303612;363465;25513;81819;25591;81525;25493;58954;24516;494344;290556;25112;294515;314322;24890;24330;140942;25695;114851;29184;79431 zfp36;zfp354a;trib3;tf;sirt3;rgn;ppargc1a;polg2;pir;pik3r1;pax8;parp1;nfkbib;nfkbia;klf6;jun;ier2;gnl3;gadd45a;foxo3;fos;esr1;egr1;ddit4;cebpd;cdkn1a;cd36;bhlhe40 ZFP36_10204;ZFP354A_10203;TRIB3_10079;TF_10003;SIRT3_9828;RGN_9699;PPARGC1A_33189;POLG2_9521;PIR_9487;PIK3R1_32562;PAX8_9432;PARP1_9425;NFKBIB_9308;NFKBIA_9307;KLF6_8969;JUN_8938;IER2_32643;GNL3_8735;GADD45A_8678;FOXO3_8662;FOS_8657;ESR1_33192;EGR1_8533;DDIT4_8450;CEBPD_8283;CDKN1A_8271;CD36_8243;BHLHE40_8141 37.03978267857148 28.76565 1.28141E-12 33.54210969400829 37.41827818266563 32.21279269994289 26.291851685714335 23.02145 1.28141E-12 25.43031063213952 27.76190710028044 26.005734017527296 65.79846142857147 43.57295 1.28142E-12 64.99656239561386 58.40168980454218 49.27732009210636 0.348134;0.834827;108.064;45.1539;2.38018;77.4407;42.4094;63.7758;50.0307;18.7324;56.8931;26.9741;30.5572;0.520151;18.9476;16.4324;49.6814;87.6357;102.919;13.1992;1.28141E-12;23.3972;0.750017;87.5421;0.306936;6.24967;48.1296;57.8085 0.118102;0.27095;83.8836;28.132;0.56209;58.7732;26.2988;40.9553;38.7717;11.6701;45.1162;21.799;24.2439;0.160202;11.6941;10.5224;33.4626;54.41;89.5012;5.6804;1.28141E-12;18.3088;0.186019;53.2453;0.0732342;2.44025;37.5433;38.3491 1.15962;2.99857;143.428;61.5341;8.82917;89.8047;81.7305;132.567;73.0083;41.5978;81.5688;35.2797;41.2611;2.88499;45.5481;39.929;89.4404;238.963;115.437;32.7581;1.28142E-12;31.9156;4.70178;245.492;1.73689;19.0606;69.1421;110.58 9 19 9 24825;293615;25106;363465;81819;25591;81525;290556;29184 TF_10003;SIRT3_9828;RGN_9699;PIR_9487;PAX8_9432;PARP1_9425;NFKBIB_9308;GNL3_8735;CD36_8243 47.24390888888889 48.1296 25.863667175252075 34.37237666666667 37.5433 17.973934928116034 77.71010777777776 69.1421 65.56895050186137 45.1539;2.38018;77.4407;50.0307;56.8931;26.9741;30.5572;87.6357;48.1296 28.132;0.56209;58.7732;38.7717;45.1162;21.799;24.2439;54.41;37.5433 61.5341;8.82917;89.8047;73.0083;81.5688;35.2797;41.2611;238.963;69.1421 19 79426;24522;246273;83516;303612;25513;25493;58954;24516;494344;25112;294515;314322;24890;24330;140942;25695;114851;79431 ZFP36_10204;ZFP354A_10203;TRIB3_10079;PPARGC1A_33189;POLG2_9521;PIK3R1_32562;NFKBIA_9307;KLF6_8969;JUN_8938;IER2_32643;GADD45A_8678;FOXO3_8662;FOS_8657;ESR1_33192;EGR1_8533;DDIT4_8450;CEBPD_8283;CDKN1A_8271;BHLHE40_8141 32.20624921052638 18.7324 36.24340896414583 22.46423458947375 11.6701 27.89902807814015 60.15610263157902 39.929 65.73801633780006 0.348134;0.834827;108.064;42.4094;63.7758;18.7324;0.520151;18.9476;16.4324;49.6814;102.919;13.1992;1.28141E-12;23.3972;0.750017;87.5421;0.306936;6.24967;57.8085 0.118102;0.27095;83.8836;26.2988;40.9553;11.6701;0.160202;11.6941;10.5224;33.4626;89.5012;5.6804;1.28141E-12;18.3088;0.186019;53.2453;0.0732342;2.44025;38.3491 1.15962;2.99857;143.428;81.7305;132.567;41.5978;2.88499;45.5481;39.929;89.4404;115.437;32.7581;1.28142E-12;31.9156;4.70178;245.492;1.73689;19.0606;110.58 0 Exp 2,11(0.4);Exp 4,3(0.11);Hill,6(0.22);Linear,1(0.04);Poly 2,7(0.25) 1.90078148291371 55.57172977924347 1.5209722518920898 4.591650485992432 0.7319455780378482 1.7612056136131287 24.615611380740212 49.46395397640273 16.872332808307522 35.71137056312115 41.72339780436734 89.87352505277563 DOWN 0.32142857142857145 0.6785714285714286 0.0 GO:1903052 9 positive regulation of proteolysis involved in cellular protein catabolic process 37 38 3 3 3 3 3 3 159 35 2350 0.7804 0.43898 0.7315 7.89 246273;25106;25423 trib3;rgn;ctsc TRIB3_10079;RGN_9699;CTSC_32456 80.5811 77.4407 56.2386 26.055030328326218 75.03506142081021 25.14195733125236 60.3083 58.7732 38.2681 22.84646272555119 55.378507588283924 22.234883198725306 112.04023333333333 102.888 89.8047 27.958667832415305 108.47919621471596 24.825830427753278 0.5 66.83965 108.064;77.4407;56.2386 83.8836;58.7732;38.2681 143.428;89.8047;102.888 1 2 1 25106 RGN_9699 77.4407 77.4407 58.7732 58.7732 89.8047 89.8047 77.4407 58.7732 89.8047 2 246273;25423 TRIB3_10079;CTSC_32456 82.15129999999999 82.15129999999999 36.64609177770533 61.07585 61.07585 32.25502937721496 123.158 123.158 28.666108909302647 108.064;56.2386 83.8836;38.2681 143.428;102.888 0 Exp 2,1(0.34);Poly 2,2(0.67) 1.7190972045217732 5.170663952827454 1.5736411809921265 1.87713623046875 0.15178077129564269 1.7198865413665771 51.097057603346094 110.06514239665393 34.45509364692964 86.16150635307037 80.40202231084587 143.6784443558208 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0040008 4 regulation of growth 171 186 11 11 9 10 9 9 153 177 2208 0.23931 0.85201 0.43813 4.84 29441;25591;24567;25685;29455;25661;116663;114851;25373 por;parp1;mt1;igfbp1;gdf15;fn1;dusp6;cdkn1a;ahsg POR_9531;PARP1_9425;MT1A_9255;IGFBP1_32306;GDF15_33113;FN1_8655;DUSP6_8506;CDKN1A_8271;AHSG_8003 38.57163 26.9741 6.24967 33.08102964894835 40.83207610503706 35.174858734960374 26.679454444444445 21.799 2.44025 25.439766476568774 27.865873443117827 27.370319870237207 69.53602222222223 79.2355 15.4235 47.09261337220992 71.99006946417168 47.11122732550894 12.4414;26.9741;12.9315;49.0259;105.149;59.5777;62.3934;6.24967;12.402 8.48981;21.799;8.91033;32.6883;85.3487;31.0499;39.0875;2.44025;10.3013 79.2355;35.2797;23.4636;89.1623;125.652;105.243;133.304;19.0606;15.4235 1 8 1 25591 PARP1_9425 26.9741 26.9741 21.799 21.799 35.2797 35.2797 26.9741 21.799 35.2797 8 29441;24567;25685;29455;25661;116663;114851;25373 POR_9531;MT1A_9255;IGFBP1_32306;GDF15_33113;FN1_8655;DUSP6_8506;CDKN1A_8271;AHSG_8003 40.02132125 30.9787 35.05815707244441 27.289511249999997 20.6756 27.12578519476174 73.8180625 84.19890000000001 48.43483296447883 12.4414;12.9315;49.0259;105.149;59.5777;62.3934;6.24967;12.402 8.48981;8.91033;32.6883;85.3487;31.0499;39.0875;2.44025;10.3013 79.2355;23.4636;89.1623;125.652;105.243;133.304;19.0606;15.4235 0 Exp 2,4(0.45);Exp 4,1(0.12);Poly 2,3(0.34);Power,1(0.12) 2.0911959278556718 19.94927167892456 1.522104263305664 3.9562058448791504 0.8780717605034308 1.8086696863174438 16.958690629353743 60.18456937064626 10.058807013086174 43.30010187580271 38.768848152378396 100.30319629206603 DOWN 0.1111111111111111 0.8888888888888888 0.0 GO:0006875 8 cellular metal ion homeostasis 132 139 18 18 14 13 10 10 152 129 2256 0.73337 0.39001 0.59518 7.19 24825;29573;25106;24567;288001;81678;81869;24890;29184;155423 tf;slc37a4;rgn;mt1;kng1;itpr2;gstm7;esr1;cd36;anxa7 TF_10003;SLC37A4_9871;RGN_9699;MT1A_9255;KNG1L1_34113;ITPR2_8931;GSTM7_8761;ESR1_33192;CD36_8243;ANXA7_8051 44.99013 41.0159 12.9315 27.384236186862854 49.19463887845401 24.44016185137279 29.395983 26.433100000000003 8.91033 14.347227762324021 32.09564068915439 12.719548236592201 58.56579000000001 60.78375 23.4636 26.85447071575275 64.6512720368685 22.40883233291124 5.5 43.73455 45.1539;39.7166;77.4407;12.9315;24.3655;31.8111;42.3152;23.3972;48.1296;104.64 28.132;22.6911;58.7732;8.91033;19.538;24.7342;31.4035;18.3088;37.5433;43.9254 61.5341;60.0334;89.8047;23.4636;32.1467;44.3296;64.5991;31.9156;69.1421;108.689 5 5 5 24825;25106;81869;29184;155423 TF_10003;RGN_9699;GSTM7_8761;CD36_8243;ANXA7_8051 63.53588 48.1296 26.965072835188135 39.95548 37.5433 12.130710040925067 78.7538 69.1421 20.046801284244825 45.1539;77.4407;42.3152;48.1296;104.64 28.132;58.7732;31.4035;37.5433;43.9254 61.5341;89.8047;64.5991;69.1421;108.689 5 29573;24567;288001;81678;24890 SLC37A4_9871;MT1A_9255;KNG1L1_34113;ITPR2_8931;ESR1_33192 26.444380000000002 24.3655 10.014470545016332 18.836486 19.538 6.102053483416877 38.37778 32.1467 14.207471030130598 39.7166;12.9315;24.3655;31.8111;23.3972 22.6911;8.91033;19.538;24.7342;18.3088 60.0334;23.4636;32.1467;44.3296;31.9156 0 Exp 2,2(0.2);Exp 3,1(0.1);Linear,3(0.3);Poly 2,4(0.4) 1.984922768483733 20.17286467552185 1.5461770296096802 2.6703107357025146 0.3877083846711665 1.8640280961990356 28.01720456643978 61.96305543356022 20.503479103723617 38.28848689627638 41.92121660726611 75.21036339273388 CONFLICT 0.5 0.5 0.0 GO:0019369 6 arachidonic acid metabolic process 29 34 11 11 7 8 4 4 158 30 2355 0.93913 0.16664 0.27209 11.76 29328;25315;65210;24894 gpx4;ephx1;cyp2j4;cyp2a1 GPX4_32827;EPHX1_8567;CYP2J4_32580;CYP2A1_32717 32.907075 31.87995 12.4747 20.972272933308087 26.565915913538515 19.451699280237477 23.6546625 24.43495 7.00435 15.24945201613132 19.069221590909088 14.387374251195311 53.396249999999995 47.056599999999996 22.6149 36.557073150577395 42.53633393079522 33.24154584811771 0.5 15.1571 2.5 50.65705 45.9204;12.4747;17.8395;55.3937 34.2198;7.00435;14.6501;38.7444 70.4292;23.684;22.6149;96.8569 4 0 4 29328;25315;65210;24894 GPX4_32827;EPHX1_8567;CYP2J4_32580;CYP2A1_32717 32.907075 31.87995 20.972272933308087 23.6546625 24.43495 15.24945201613132 53.396249999999995 47.056599999999996 36.557073150577395 45.9204;12.4747;17.8395;55.3937 34.2198;7.00435;14.6501;38.7444 70.4292;23.684;22.6149;96.8569 0 0 Exp 2,1(0.25);Hill,1(0.25);Linear,2(0.5) 2.215862159194629 9.473827838897705 1.547789216041565 3.8079800605773926 1.0385311563882742 2.059029281139374 12.35424752535808 53.45990247464192 8.710199524191303 38.5991254758087 17.570318312434146 89.22218168756584 UP 1.0 0.0 0.0 GO:1902679 8 negative regulation of RNA biosynthetic process 225 236 17 17 13 15 12 12 150 224 2161 0.24642 0.83727 0.48395 5.08 79426;24522;246273;25106;24516;25112;294515;24890;24330;25695;29184;79431 zfp36;zfp354a;trib3;rgn;jun;gadd45a;foxo3;esr1;egr1;cebpd;cd36;bhlhe40 ZFP36_10204;ZFP354A_10203;TRIB3_10079;RGN_9699;JUN_8938;GADD45A_8678;FOXO3_8662;ESR1_33192;EGR1_8533;CEBPD_8283;CD36_8243;BHLHE40_8141 37.4692095 19.9148 0.306936 40.532072936796375 40.38394520592295 43.306474803338546 28.600858766666665 14.415600000000001 0.0732342 33.088837584615305 32.080820480114404 36.11211817555327 53.632613333333325 36.34355 1.15962 50.60968239607343 53.61962438234756 51.43071004542423 10.5 105.4915 0.348134;0.834827;108.064;77.4407;16.4324;102.919;13.1992;23.3972;0.750017;0.306936;48.1296;57.8085 0.118102;0.27095;83.8836;58.7732;10.5224;89.5012;5.6804;18.3088;0.186019;0.0732342;37.5433;38.3491 1.15962;2.99857;143.428;89.8047;39.929;115.437;32.7581;31.9156;4.70178;1.73689;69.1421;110.58 2 10 2 25106;29184 RGN_9699;CD36_8243 62.78515 62.78515 20.726077574037024 48.15825 48.15825 15.0118062539123 79.4734 79.4734 14.610664576945227 77.4407;48.1296 58.7732;37.5433 89.8047;69.1421 10 79426;24522;246273;24516;25112;294515;24890;24330;25695;79431 ZFP36_10204;ZFP354A_10203;TRIB3_10079;JUN_8938;GADD45A_8678;FOXO3_8662;ESR1_33192;EGR1_8533;CEBPD_8283;BHLHE40_8141 32.4060214 14.8158 42.300007336915165 24.689380519999997 8.1014 34.801418949771694 48.464456 32.33685 54.117851790575685 0.348134;0.834827;108.064;16.4324;102.919;13.1992;23.3972;0.750017;0.306936;57.8085 0.118102;0.27095;83.8836;10.5224;89.5012;5.6804;18.3088;0.186019;0.0732342;38.3491 1.15962;2.99857;143.428;39.929;115.437;32.7581;31.9156;4.70178;1.73689;110.58 0 Exp 2,3(0.25);Exp 4,1(0.09);Hill,4(0.34);Poly 2,4(0.34) 2.2164752315585954 28.384673476219177 1.627708911895752 4.591650485992432 1.0060700511752436 1.9583411812782288 14.536030343544528 60.40238865645547 9.879086465750209 47.32263106758313 24.997489853458365 82.2677368132083 DOWN 0.16666666666666666 0.8333333333333334 0.0 GO:0010039 6 response to iron ion 30 31 6 6 4 6 4 4 158 27 2358 0.95673 0.13045 0.13045 12.9 24825;25513;25661;312382 tf;pik3r1;fn1;abcg2 TF_10003;PIK3R1_32562;FN1_8655;ABCG2_32656 32.170135 31.94315 5.21654 24.6767216769077 35.65783948869847 26.400961297433238 18.39642 19.90105 2.73368 13.484026093824257 19.941180246835216 14.283499797920614 54.940225 51.56595 11.386 39.36512492231121 60.09421658380055 43.78681621746257 0.5 11.97447 2.5 52.3658 45.1539;18.7324;59.5777;5.21654 28.132;11.6701;31.0499;2.73368 61.5341;41.5978;105.243;11.386 2 2 2 24825;312382 TF_10003;ABCG2_32656 25.18522 25.18522 28.239978078688374 15.43284 15.43284 17.959324302745916 36.46005 36.46005 35.460061573621104 45.1539;5.21654 28.132;2.73368 61.5341;11.386 2 25513;25661 PIK3R1_32562;FN1_8655 39.15505 39.15505 28.881988609598878 21.36 21.36 13.703587998039058 73.4204 73.4204 45.00395250997403 18.7324;59.5777 11.6701;31.0499 41.5978;105.243 0 Exp 4,1(0.25);Poly 2,2(0.5);Power,1(0.25) 1.6939762350235192 6.794720888137817 1.5074360370635986 1.8344712257385254 0.14391246904209246 1.7264068126678467 7.98694775663045 56.353322243369554 5.182074428052232 31.610765571947766 16.36240257613502 93.51804742386497 CONFLICT 0.5 0.5 0.0 GO:2000145 5 regulation of cell motility 264 277 17 17 17 14 14 14 148 263 2122 0.21092 0.86004 0.43316 5.05 24825;25106;83516;85253;25513;307582;24516;24471;24957;25112;294515;25661;361969;24330 tf;rgn;ppargc1a;plg;pik3r1;lama3;jun;hspb1;glul;gadd45a;foxo3;fn1;fga;egr1 TF_10003;RGN_9699;PPARGC1A_33189;PLG_9501;PIK3R1_32562;LAMA3_8980;JUN_8938;HSPB1_8847;GLUL_32832;GADD45A_8678;FOXO3_8662;FN1_8655;FGA_8632;EGR1_8533 42.429853357142854 35.49485 0.750017 32.8644994315027 50.64557869003506 32.62945232770938 29.48730142857143 24.413899999999998 0.186019 25.938294862021664 35.51357854947168 26.57218809190328 65.29656285714286 51.56595 4.70178 43.3895318259025 75.90248816842772 44.224259895816196 12.5 96.01005 45.1539;77.4407;42.4094;70.7857;18.7324;2.46923;16.4324;89.1011;26.4669;102.919;13.1992;59.5777;28.5803;0.750017 28.132;58.7732;26.2988;46.2356;11.6701;0.871501;10.5224;60.3265;21.0456;89.5012;5.6804;31.0499;22.529;0.186019 61.5341;89.8047;81.7305;150.579;41.5978;10.4175;39.929;106.138;35.4303;115.437;32.7581;105.243;38.8511;4.70178 2 12 2 24825;25106 TF_10003;RGN_9699 61.29730000000001 61.29730000000001 22.830215222813823 43.452600000000004 43.452600000000004 21.666600303693237 75.6694 75.6694 19.990332968212424 45.1539;77.4407 28.132;58.7732 61.5341;89.8047 12 83516;85253;25513;307582;24516;24471;24957;25112;294515;25661;361969;24330 PPARGC1A_33189;PLG_9501;PIK3R1_32562;LAMA3_8980;JUN_8938;HSPB1_8847;GLUL_32832;GADD45A_8678;FOXO3_8662;FN1_8655;FGA_8632;EGR1_8533 39.28527891666667 27.523600000000002 33.96407086075686 27.15975166666667 21.787300000000002 26.66599174418663 63.567756666666675 40.763400000000004 46.538155385786645 42.4094;70.7857;18.7324;2.46923;16.4324;89.1011;26.4669;102.919;13.1992;59.5777;28.5803;0.750017 26.2988;46.2356;11.6701;0.871501;10.5224;60.3265;21.0456;89.5012;5.6804;31.0499;22.529;0.186019 81.7305;150.579;41.5978;10.4175;39.929;106.138;35.4303;115.437;32.7581;105.243;38.8511;4.70178 0 Exp 2,1(0.08);Exp 4,2(0.15);Hill,1(0.08);Linear,3(0.22);Poly 2,6(0.43);Power,1(0.08) 1.8847384645757572 27.401056170463562 1.5254690647125244 4.21828556060791 0.685200883891521 1.7387548089027405 25.214375768671445 59.64533094561426 15.89999166865888 43.074611188483985 42.56773614003569 88.02538957425 DOWN 0.14285714285714285 0.8571428571428571 0.0 GO:0032042 6 mitochondrial DNA metabolic process 5 5 2 2 2 2 2 2 160 3 2382 0.9977 0.035397 0.035397 40.0 303612;25591 polg2;parp1 POLG2_9521;PARP1_9425 45.37495 45.37495 26.9741 26.022731629192965 39.335121132205145 24.58095799476706 31.37715 31.37715 21.799 13.545549632443857 28.2332524697191 12.795066685374758 83.92335 83.92335 35.2797 68.79250955333005 67.95673315866335 64.98110236006227 0.0 26.9741 0.0 26.9741 63.7758;26.9741 40.9553;21.799 132.567;35.2797 1 1 1 25591 PARP1_9425 26.9741 26.9741 21.799 21.799 35.2797 35.2797 26.9741 21.799 35.2797 1 303612 POLG2_9521 63.7758 63.7758 40.9553 40.9553 132.567 132.567 63.7758 40.9553 132.567 0 Exp 2,2(1) 1.6745926312297734 3.3591244220733643 1.5504547357559204 1.8086696863174438 0.18258554254580234 1.6795622110366821 9.309284000000005 81.44061599999999 12.603976 50.150324 -11.418204000000017 179.264904 CONFLICT 0.5 0.5 0.0 GO:1901652 5 response to peptide 225 236 38 37 29 33 25 25 137 211 2174 0.99697 0.0061928 0.010823 10.59 286954;246273;25351;29441;24651;25513;25591;25493;58954;24471;29540;24464;113965;294515;25661;361969;29496;24330;497840;81718;29184;25698;25373;312382;25303 ugt2b1;trib3;slc2a2;por;pklr;pik3r1;parp1;nfkbia;klf6;hspb1;hsd17b7;hp;hadh;foxo3;fn1;fga;erbb3;egr1;cps1;cdo1;cd36;ass1;ahsg;abcg2;abcc2 UGT2B10_33303,UGT2B1_33224;TRIB3_10079;SLC2A2_9863;POR_9531;PKLR_9489;PIK3R1_32562;PARP1_9425;NFKBIA_9307;KLF6_8969;HSPB1_8847;HSD17B7_8834;HP_8823;HADH_8776;FOXO3_8662;FN1_8655;FGA_8632;ERBB3_8571;EGR1_8533;CPS1_32421;CDO1_8275;CD36_8243;ASS1_33159;AHSG_8003;ABCG2_32656;ABCC2_32541 33.24639807999999 26.9741 0.520151 27.18815983363403 36.670286917912556 25.893244573279446 23.52431772 21.799 0.160202 19.610969302488638 25.777252645960992 18.039785115968435 55.1540776 41.5978 2.88499 40.525080081264115 60.375689051570745 40.117201762482615 10.5 24.95 22.5 77.01480000000001 47.47345;108.064;29.7555;12.4414;23.0963;18.7324;26.9741;0.520151;18.9476;89.1011;0.977494;64.9285;33.3125;13.1992;59.5777;28.5803;60.9984;0.750017;31.9826;22.9638;48.1296;26.8037;12.402;5.21654;46.2316 34.82915;83.8836;23.3399;8.48981;17.4625;11.6701;21.799;0.160202;11.6941;60.3265;0.322682;41.6103;25.7336;5.6804;31.0499;22.529;41.6036;0.186019;24.4836;18.5144;37.5433;20.9825;10.3013;2.73368;31.1788 76.47475;143.428;40.808;79.2355;32.9443;41.5978;35.2797;2.88499;45.5481;106.138;5.49472;136.455;46.9856;32.7581;105.243;38.8511;113.972;4.70178;45.5891;30.0179;69.1421;36.7081;15.4235;11.386;81.7848 7 19 6 286954;25591;113965;29496;29184;312382 UGT2B10_33303,UGT2B1_33224;PARP1_9425;HADH_8776;ERBB3_8571;CD36_8243;ABCG2_32656 37.01743166666667 40.392975 19.666149532005917 27.373721666666665 30.281374999999997 14.159041963142023 58.87335833333333 58.06385 35.78867158963038 47.47345;26.9741;33.3125;60.9984;48.1296;5.21654 34.82915;21.799;25.7336;41.6036;37.5433;2.73368 76.47475;35.2797;46.9856;113.972;69.1421;11.386 19 246273;25351;29441;24651;25513;25493;58954;24471;29540;24464;294515;25661;361969;24330;497840;81718;25698;25373;25303 TRIB3_10079;SLC2A2_9863;POR_9531;PKLR_9489;PIK3R1_32562;NFKBIA_9307;KLF6_8969;HSPB1_8847;HSD17B7_8834;HP_8823;FOXO3_8662;FN1_8655;FGA_8632;EGR1_8533;CPS1_32421;CDO1_8275;ASS1_33159;AHSG_8003;ABCC2_32541 32.05554536842105 23.0963 29.528375258161073 22.30871647368421 18.5144 21.227323790010512 53.97956789473684 40.808 42.75343873143703 108.064;29.7555;12.4414;23.0963;18.7324;0.520151;18.9476;89.1011;0.977494;64.9285;13.1992;59.5777;28.5803;0.750017;31.9826;22.9638;26.8037;12.402;46.2316 83.8836;23.3399;8.48981;17.4625;11.6701;0.160202;11.6941;60.3265;0.322682;41.6103;5.6804;31.0499;22.529;0.186019;24.4836;18.5144;20.9825;10.3013;31.1788 143.428;40.808;79.2355;32.9443;41.5978;2.88499;45.5481;106.138;5.49472;136.455;32.7581;105.243;38.8511;4.70178;45.5891;30.0179;36.7081;15.4235;81.7848 0 Exp 2,10(0.39);Exp 4,4(0.16);Hill,1(0.04);Linear,5(0.2);Poly 2,5(0.2);Power,1(0.04) 1.933883796564553 51.984039545059204 1.5074360370635986 4.21828556060791 0.617296695145161 1.8175725936889648 22.58863942521546 43.904156734784536 15.83681775342445 31.211817686575543 39.268246208144475 71.03990899185554 DOWN 0.24 0.76 0.0 GO:0070447 8 positive regulation of oligodendrocyte progenitor proliferation 2 2 1 1 1 1 1 1 161 1 2384 0.99598 0.12319 0.12319 50.0 24825 tf TF_10003 45.1539 45.1539 45.1539 45.1539 28.132 28.132 28.132 28.131999999999998 61.5341 61.5341 61.5341 61.53410000000001 0.0 45.1539 0.0 45.1539 45.1539 28.132 61.5341 1 0 1 24825 TF_10003 45.1539 45.1539 28.132 28.132 61.5341 61.5341 45.1539 28.132 61.5341 0 0 Poly 2,1(1) 1.8344712257385254 1.8344712257385254 1.8344712257385254 1.8344712257385254 0.0 1.8344712257385254 45.1539 45.1539 28.132 28.132 61.5341 61.5341 UP 1.0 0.0 0.0 GO:0030163 5 protein catabolic process 61 67 2 2 2 2 2 2 160 65 2320 0.18903 0.93452 0.44002 2.99 29676;25377 psmb3;ambp PSMB3_9589;AMBP_33085 20.51155 20.51155 17.2343 4.634731397287216 21.514178995433788 4.412505560339921 16.697850000000003 16.697850000000003 14.1233 3.6409635270076426 17.48549771689498 3.4663868152790114 26.40415 26.40415 21.9073 6.3595062579574275 27.779898630136987 6.05458101426946 23.7888;17.2343 19.2724;14.1233 30.901;21.9073 1 1 1 29676 PSMB3_9589 23.7888 23.7888 19.2724 19.2724 30.901 30.901 23.7888 19.2724 30.901 1 25377 AMBP_33085 17.2343 17.2343 14.1233 14.1233 21.9073 21.9073 17.2343 14.1233 21.9073 0 Exp 2,2(1) 1.6351868692679665 3.2704066038131714 1.6278724670410156 1.6425341367721558 0.010367366090406735 1.6352033019065857 14.088140000000003 26.934959999999997 11.651732000000003 21.743968000000002 17.590324000000003 35.217976 CONFLICT 0.5 0.5 0.0 GO:0006633 6 fatty acid biosynthetic process 33 37 4 4 3 3 2 2 160 35 2350 0.57834 0.69335 1.0 5.41 246074;24539 scd;lpl SCD1_9787;LPL_32544 89.83205 89.83205 74.2041 22.101258842088587 83.65115768202546 20.29923108672376 56.8107 56.8107 49.8682 9.818177656775244 54.064924327724476 9.017651823788794 289.062 289.062 155.425 188.99125783485337 236.20824076112595 173.58184181140115 0.5 89.83205 105.46;74.2041 63.7532;49.8682 422.699;155.425 2 0 2 246074;24539 SCD1_9787;LPL_32544 89.83205 89.83205 22.101258842088587 56.8107 56.8107 9.818177656775244 289.062 289.062 188.99125783485337 105.46;74.2041 63.7532;49.8682 422.699;155.425 0 0 Exp 2,2(1) 1.8676450691919462 3.7962210178375244 1.559399127960205 2.2368218898773193 0.4790102286817116 1.8981105089187622 59.201268 120.46283199999999 43.2034 70.41799999999999 27.13348000000002 550.9905200000001 UP 1.0 0.0 0.0 GO:0016485 6 protein processing 34 36 3 3 3 2 2 2 160 34 2351 0.59583 0.67866 1.0 5.56 25591;361969 parp1;fga PARP1_9425;FGA_8632 27.7772 27.7772 26.9741 1.135754911941811 27.845795551875078 1.1316044010720294 22.164 22.164 21.799 0.5161879502660341 22.19517591387673 0.5143015893303787 37.0654 37.0654 35.2797 2.5253611583297815 37.21792282030049 2.5161324604590143 0.5 27.7772 26.9741;28.5803 21.799;22.529 35.2797;38.8511 1 1 1 25591 PARP1_9425 26.9741 26.9741 21.799 21.799 35.2797 35.2797 26.9741 21.799 35.2797 1 361969 FGA_8632 28.5803 28.5803 22.529 22.529 38.8511 38.8511 28.5803 22.529 38.8511 0 Exp 2,1(0.5);Linear,1(0.5) 1.6699641651859112 3.350565552711487 1.541895866394043 1.8086696863174438 0.18863757711087567 1.6752827763557434 26.203124 29.351276000000002 21.448600000000003 22.8794 33.56542799999999 40.565372 CONFLICT 0.5 0.5 0.0 GO:0017001 5 antibiotic catabolic process 20 22 3 3 2 3 2 2 160 20 2365 0.83934 0.41295 0.64706 9.09 286954;360268 ugt2b1;sult1e1 UGT2B10_33303,UGT2B1_33224;SULT1E1_32446 48.829025 48.829025 47.47345 1.9170725498139347 48.41971682374372 1.827594264312584 35.665025 35.665025 34.82915 1.1821057614485728 35.412637288638976 1.126931638369132 78.726775 78.726775 76.47475 3.184844297803276 78.04678883498993 3.0361934773720627 0.5 48.829025 47.47345;50.1846 34.82915;36.5009 76.47475;80.9788 3 0 2 286954;360268 UGT2B10_33303,UGT2B1_33224;SULT1E1_32446 48.829025 48.829025 1.9170725498139347 35.665025 35.665025 1.1821057614485728 78.726775 78.726775 3.184844297803276 47.47345;50.1846 34.82915;36.5009 76.47475;80.9788 0 0 Exp 2,3(1) 1.7174775202600592 5.155168652534485 1.6419988870620728 1.7730062007904053 0.06816384541320031 1.7401635646820068 46.172098 51.485952000000005 34.026709999999994 37.303340000000006 74.312806 83.14074400000001 UP 1.0 0.0 0.0 GO:0061732 10 mitochondrial acetyl-CoA biosynthetic process from pyruvate 1 1 1 1 1 1 1 1 161 0 2385 1.0 0.063604 0.063604 100.0 100359982 mpc2 MPC2_33219 46.8463 46.8463 46.8463 46.84629999999999 35.8494 35.8494 35.8494 35.849399999999996 69.127 69.127 69.127 69.127 0.0 46.8463 0.0 46.8463 46.8463 35.8494 69.127 1 0 1 100359982 MPC2_33219 46.8463 46.8463 35.8494 35.8494 69.127 69.127 46.8463 35.8494 69.127 0 0 Exp 2,1(1) 1.9223796129226685 1.9223796129226685 1.9223796129226685 1.9223796129226685 0.0 1.9223796129226685 46.8463 46.8463 35.8494 35.8494 69.127 69.127 UP 1.0 0.0 0.0 GO:0008286 8 insulin receptor signaling pathway 24 24 4 4 4 4 4 4 158 20 2365 0.98452 0.061808 0.061808 16.67 25513;25685;294515;116636 pik3r1;igfbp1;foxo3;eif4ebp1 PIK3R1_32562;IGFBP1_32306;FOXO3_8662;EIF4EBP1_8550 41.2144 33.879149999999996 13.1992 32.52373631559982 54.00365001557389 36.45039616379623 23.114325 22.179199999999998 5.6804 17.313041293463336 28.559546667185796 17.987143452597252 67.70955 65.38005 32.7581 36.20605647738144 78.52079577168664 37.63877305769764 0.5 15.965799999999998 1.5 33.879149999999996 18.7324;49.0259;13.1992;83.9001 11.6701;32.6883;5.6804;42.4185 41.5978;89.1623;32.7581;107.32 1 3 1 116636 EIF4EBP1_8550 83.9001 83.9001 42.4185 42.4185 107.32 107.32 83.9001 42.4185 107.32 3 25513;25685;294515 PIK3R1_32562;IGFBP1_32306;FOXO3_8662 26.985833333333332 18.7324 19.286717698025587 16.679599999999997 11.6701 14.183722476486912 54.50606666666666 41.5978 30.33687452034792 18.7324;49.0259;13.1992 11.6701;32.6883;5.6804 41.5978;89.1623;32.7581 0 Exp 2,1(0.25);Exp 3,1(0.25);Exp 4,1(0.25);Poly 2,1(0.25) 2.1662995743867532 9.290980100631714 1.672852873802185 3.9562058448791504 1.099059454361754 1.8309606909751892 9.341138410712176 73.08766158928782 6.147544532405927 40.08110546759407 32.227614652166196 103.19148534783379 DOWN 0.25 0.75 0.0 GO:0042760 7 very long-chain fatty acid catabolic process 2 2 2 2 2 2 2 2 160 0 2385 1.0 0.0040221 0.0040221 100.0 65192;192272 slc27a2;acot2 SLC27A2_9860;ACOT2_7969 8.085469999999999 8.085469999999999 7.62189 0.6556011232449381 7.724644881516587 0.41161061762646706 6.3479600000000005 6.3479600000000005 5.49916 1.200384471742278 5.687300867663144 0.7536457401988104 11.9025 11.9025 10.4125 2.1071782079359127 13.062233868027707 1.3229643648636207 0.0 7.62189 0.0 7.62189 7.62189;8.54905 5.49916;7.19676 13.3925;10.4125 2 0 2 65192;192272 SLC27A2_9860;ACOT2_7969 8.085469999999999 8.085469999999999 0.6556011232449381 6.3479600000000005 6.3479600000000005 1.200384471742278 11.9025 11.9025 2.1071782079359127 7.62189;8.54905 5.49916;7.19676 13.3925;10.4125 0 0 Hill,1(0.5);Linear,1(0.5) 5.085111491335303 14.020765781402588 2.18471097946167 11.836054801940918 6.824530664437971 7.010382890701294 7.176853199999999 8.994086799999998 4.684312 8.011608 8.982099999999999 14.8229 UP 1.0 0.0 0.0 GO:0000447 11 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) 1 1 1 1 1 1 1 1 161 0 2385 1.0 0.063604 0.063604 100.0 297784 rrs1 RRS1_9755 60.39 60.39 60.39 60.39 43.109 43.109 43.109 43.10900000000001 104.942 104.942 104.942 104.942 0.0 60.39 0.0 60.39 60.39 43.109 104.942 1 0 1 297784 RRS1_9755 60.39 60.39 43.109 43.109 104.942 104.942 60.39 43.109 104.942 0 0 Exp 2,1(1) 2.281954288482666 2.281954288482666 2.281954288482666 2.281954288482666 0.0 2.281954288482666 60.39 60.39 43.109 43.109 104.942 104.942 UP 1.0 0.0 0.0 GO:0062197 5 cellular response to chemical stress 112 118 13 13 13 11 11 11 151 107 2278 0.93189 0.12589 0.17544 9.32 83516;25591;24314;58954;24516;24471;294515;314322;24360;24330;29184 ppargc1a;parp1;nqo1;klf6;jun;hspb1;foxo3;fos;fabp1;egr1;cd36 PPARGC1A_33189;PARP1_9425;NQO1_33055;KLF6_8969;JUN_8938;HSPB1_8847;FOXO3_8662;FOS_8657;FABP1_33091;EGR1_8533;CD36_8243 34.27888336363648 26.9741 1.28141E-12 30.69664663127645 36.09297686612207 28.33910815787663 23.747574454545575 21.799 1.28141E-12 21.626853316565313 25.669265644127837 19.779199946111554 59.93363454545466 45.5481 1.28142E-12 55.0266100768702 55.09248391770049 39.144714486389844 4.5 22.96085 42.4094;26.9741;87.2765;18.9476;16.4324;89.1011;13.1992;1.28141E-12;33.8478;0.750017;48.1296 26.2988;21.799;60.6992;11.6941;10.5224;60.3265;5.6804;1.28141E-12;26.4736;0.186019;37.5433 81.7305;35.2797;197.117;45.5481;39.929;106.138;32.7581;1.28142E-12;46.9257;4.70178;69.1421 4 7 4 25591;24314;24360;29184 PARP1_9425;NQO1_33055;FABP1_33091;CD36_8243 49.057 40.9887 26.960245350391993 36.628775 32.00845 17.3519597499101 87.116125 58.0339 74.6671353272364 26.9741;87.2765;33.8478;48.1296 21.799;60.6992;26.4736;37.5433 35.2797;197.117;46.9257;69.1421 7 83516;58954;24516;24471;294515;314322;24330 PPARGC1A_33189;KLF6_8969;JUN_8938;HSPB1_8847;FOXO3_8662;FOS_8657;EGR1_8533 25.83424528571447 16.4324 31.277047880869098 16.386888428571613 10.5224 21.334546010696602 44.40078285714304 39.929 38.534178230388825 42.4094;18.9476;16.4324;89.1011;13.1992;1.28141E-12;0.750017 26.2988;11.6941;10.5224;60.3265;5.6804;1.28141E-12;0.186019 81.7305;45.5481;39.929;106.138;32.7581;1.28142E-12;4.70178 0 Exp 2,5(0.46);Exp 4,1(0.1);Hill,2(0.19);Poly 2,3(0.28) 2.0054877991621436 23.04183828830719 1.5740432739257812 4.21828556060791 0.7645792120662042 1.8753424882888794 16.138324451980182 52.41944227529277 10.966920874516768 36.528228034574376 27.4149860494611 92.45228304144823 DOWN 0.36363636363636365 0.6363636363636364 0.0 GO:0009605 3 response to external stimulus 571 616 75 75 61 64 52 52 110 564 1821 0.99308 0.011242 0.017677 8.44 79426;24522;312688;286954;25357;24825;29573;29482;29500;24648;246074;83516;29441;24651;25513;24314;81525;25493;24539;24516;63868;24471;24464;25675;24957;24384;25112;294515;314322;25661;25256;361969;80841;304929;308441;116636;24330;140942;25146;497840;114851;29184;54232;313421;246142;79431;25698;192272;24158;312382;140668;25303 zfp36;zfp354a;usp18;ugt2b1;thrsp;tf;slc37a4;slc1a2;slc10a2;serpina1;scd;ppargc1a;por;pklr;pik3r1;nqo1;nfkbib;nfkbia;lpl;jun;hspd1;hspb1;hp;hmgcr;glul;gc;gadd45a;foxo3;fos;fn1;fmo1;fga;fabp7;f5;exosc5;eif4ebp1;egr1;ddit4;cyp17a1;cps1;cdkn1a;cd36;car3;c8b;bmf;bhlhe40;ass1;acot2;acadm;abcg2;abcc3;abcc2 ZFP36_10204;ZFP354A_10203;USP18_10138;UGT2B10_33303,UGT2B1_33224;THRSP_33314;TF_10003;SLC37A4_9871;SLC1A2_33059;SLC10A2_9833;SERPINA1_9807;SCD1_9787;PPARGC1A_33189;POR_9531;PKLR_9489;PIK3R1_32562;NQO1_33055;NFKBIB_9308;NFKBIA_9307;LPL_32544;JUN_8938;HSPD1_8849;HSPB1_8847;HP_8823;HMGCR_8810;GLUL_32832;GC_32893;GADD45A_8678;FOXO3_8662;FOS_8657;FN1_8655;FMO1_32787;FGA_8632;FABP7_8592;F5_33079;EXOSC5_32543;EIF4EBP1_8550;EGR1_8533;DDIT4_8450;CYP17A1_32365;CPS1_32421;CDKN1A_8271;CD36_8243;CAR3_8196;C8B_8181;BMF_8152;BHLHE40_8141;ASS1_33159;ACOT2_7969;ACADM_7957;ABCG2_32656;ABCC3_7941;ABCC2_32541 39.56496209615387 34.9614 1.28141E-12 30.7953661495756 43.015915329308164 30.251279100296685 26.537691923076952 24.32025 1.28141E-12 21.341178857351625 29.106764923278206 21.89486446149027 71.67227903846157 54.483149999999995 1.28142E-12 71.2372090311604 72.62995423877513 61.58877021588089 29.5 42.30695 0.348134;0.834827;108.883;47.47345;32.2053;45.1539;39.7166;13.3235;56.585;15.797;105.46;42.4094;12.4414;23.0963;18.7324;87.2765;30.5572;0.520151;74.2041;16.4324;42.2579;89.1011;64.9285;1.63089;26.4669;42.356;102.919;13.1992;1.28141E-12;59.5777;65.2792;28.5803;24.601;10.6089;41.9329;83.9001;0.750017;87.5421;49.6922;31.9826;6.24967;48.1296;53.9626;21.3618;94.8767;57.8085;26.8037;8.54905;11.7137;5.21654;37.7175;46.2316 0.118102;0.27095;73.1414;34.82915;24.3966;28.132;22.6911;9.10952;35.2796;13.013;63.7532;26.2988;8.48981;17.4625;11.6701;60.6992;24.2439;0.160202;49.8682;10.5224;23.9469;60.3265;41.6103;0.663137;21.0456;26.3722;89.5012;5.6804;1.28141E-12;31.0499;39.7882;22.529;14.4402;2.59129;31.7336;42.4185;0.186019;53.2453;35.6654;24.4836;2.44025;37.5433;28.5034;17.2088;73.1342;38.3491;20.9825;7.19676;8.36151;2.73368;30.9007;31.1788 1.15962;2.99857;138.144;76.47475;46.6068;61.5341;60.0334;24.6773;116.8;19.9134;422.699;81.7305;79.2355;32.9443;41.5978;197.117;41.2611;2.88499;155.425;39.929;102.383;106.138;136.455;7.6286;35.4303;78.7583;115.437;32.7581;1.28142E-12;105.243;82.9415;38.8511;35.6155;37.5078;62.1373;107.32;4.70178;245.492;81.6409;45.5891;19.0606;69.1421;77.0288;27.9161;109.848;110.58;36.7081;10.4125;18.9642;11.386;48.9329;81.7848 20 33 19 312688;286954;24825;246074;24314;81525;24539;63868;25256;80841;308441;116636;25146;29184;246142;192272;24158;312382;140668 USP18_10138;UGT2B10_33303,UGT2B1_33224;TF_10003;SCD1_9787;NQO1_33055;NFKBIB_9308;LPL_32544;HSPD1_8849;FMO1_32787;FABP7_8592;EXOSC5_32543;EIF4EBP1_8550;CYP17A1_32365;CD36_8243;BMF_8152;ACOT2_7969;ACADM_7957;ABCG2_32656;ABCC3_7941 53.309186315789475 47.47345 31.823272276055242 35.92263157894737 34.82915 21.009161763427638 96.49362368421052 76.47475 93.00879165147116 108.883;47.47345;45.1539;105.46;87.2765;30.5572;74.2041;42.2579;65.2792;24.601;41.9329;83.9001;49.6922;48.1296;94.8767;8.54905;11.7137;5.21654;37.7175 73.1414;34.82915;28.132;63.7532;60.6992;24.2439;49.8682;23.9469;39.7882;14.4402;31.7336;42.4185;35.6654;37.5433;73.1342;7.19676;8.36151;2.73368;30.9007 138.144;76.47475;61.5341;422.699;197.117;41.2611;155.425;102.383;82.9415;35.6155;62.1373;107.32;81.6409;69.1421;109.848;10.4125;18.9642;11.386;48.9329 33 79426;24522;25357;29573;29482;29500;24648;83516;29441;24651;25513;25493;24516;24471;24464;25675;24957;24384;25112;294515;314322;25661;361969;304929;24330;140942;497840;114851;54232;313421;79431;25698;25303 ZFP36_10204;ZFP354A_10203;THRSP_33314;SLC37A4_9871;SLC1A2_33059;SLC10A2_9833;SERPINA1_9807;PPARGC1A_33189;POR_9531;PKLR_9489;PIK3R1_32562;NFKBIA_9307;JUN_8938;HSPB1_8847;HP_8823;HMGCR_8810;GLUL_32832;GC_32893;GADD45A_8678;FOXO3_8662;FOS_8657;FN1_8655;FGA_8632;F5_33079;EGR1_8533;DDIT4_8450;CPS1_32421;CDKN1A_8271;CAR3_8196;C8B_8181;BHLHE40_8141;ASS1_33159;ABCC2_32541 31.65162087878792 26.4669 27.659452084271024 21.13424181818186 20.9825 19.87919696042839 57.38120181818185 39.929 51.434019165135126 0.348134;0.834827;32.2053;39.7166;13.3235;56.585;15.797;42.4094;12.4414;23.0963;18.7324;0.520151;16.4324;89.1011;64.9285;1.63089;26.4669;42.356;102.919;13.1992;1.28141E-12;59.5777;28.5803;10.6089;0.750017;87.5421;31.9826;6.24967;53.9626;21.3618;57.8085;26.8037;46.2316 0.118102;0.27095;24.3966;22.6911;9.10952;35.2796;13.013;26.2988;8.48981;17.4625;11.6701;0.160202;10.5224;60.3265;41.6103;0.663137;21.0456;26.3722;89.5012;5.6804;1.28141E-12;31.0499;22.529;2.59129;0.186019;53.2453;24.4836;2.44025;28.5034;17.2088;38.3491;20.9825;31.1788 1.15962;2.99857;46.6068;60.0334;24.6773;116.8;19.9134;81.7305;79.2355;32.9443;41.5978;2.88499;39.929;106.138;136.455;7.6286;35.4303;78.7583;115.437;32.7581;1.28142E-12;105.243;38.8511;37.5078;4.70178;245.492;45.5891;19.0606;77.0288;27.9161;110.58;36.7081;81.7848 0 Exp 2,20(0.38);Exp 3,3(0.06);Exp 4,5(0.1);Hill,6(0.12);Linear,5(0.1);Poly 2,12(0.23);Power,2(0.04) 1.987726818577135 115.55723810195923 1.5074360370635986 11.836054801940918 1.501025557383089 1.7792335748672485 31.194686229615165 47.93523796269259 20.737093434150133 32.33829041200378 52.30978506268161 91.0347730142415 DOWN 0.36538461538461536 0.6346153846153846 0.0 GO:0050801 6 ion homeostasis 172 181 23 23 18 18 14 14 148 167 2218 0.82898 0.2572 0.42831 7.73 24825;29573;25106;25591;24567;288001;81678;81869;304929;24890;497840;29184;155423;25303 tf;slc37a4;rgn;parp1;mt1;kng1;itpr2;gstm7;f5;esr1;cps1;cd36;anxa7;abcc2 TF_10003;SLC37A4_9871;RGN_9699;PARP1_9425;MT1A_9255;KNG1L1_34113;ITPR2_8931;GSTM7_8761;F5_33079;ESR1_33192;CPS1_32421;CD36_8243;ANXA7_8051;ABCC2_32541 40.40703571428571 35.8496 10.6089 25.01135799888976 44.20830622984213 22.85991343344356 26.715180000000007 24.6089 2.59129 14.020557145599827 29.533648577774006 12.232895150930194 56.12995 52.81125 23.4636 24.962425277874367 60.10651566230973 22.45229710542799 8.5 43.73455 45.1539;39.7166;77.4407;26.9741;12.9315;24.3655;31.8111;42.3152;10.6089;23.3972;31.9826;48.1296;104.64;46.2316 28.132;22.6911;58.7732;21.799;8.91033;19.538;24.7342;31.4035;2.59129;18.3088;24.4836;37.5433;43.9254;31.1788 61.5341;60.0334;89.8047;35.2797;23.4636;32.1467;44.3296;64.5991;37.5078;31.9156;45.5891;69.1421;108.689;81.7848 6 8 6 24825;25106;25591;81869;29184;155423 TF_10003;RGN_9699;PARP1_9425;GSTM7_8761;CD36_8243;ANXA7_8051 57.44225 46.64175 28.363463855231068 36.9294 34.4734 13.140253493597449 71.50811666666665 66.8706 25.228930916423465 45.1539;77.4407;26.9741;42.3152;48.1296;104.64 28.132;58.7732;21.799;31.4035;37.5433;43.9254 61.5341;89.8047;35.2797;64.5991;69.1421;108.689 8 29573;24567;288001;81678;304929;24890;497840;25303 SLC37A4_9871;MT1A_9255;KNG1L1_34113;ITPR2_8931;F5_33079;ESR1_33192;CPS1_32421;ABCC2_32541 27.630625000000002 28.0883 12.32227626533692 19.054515000000002 21.11455 9.232620260956717 44.59632500000001 40.9187 18.65083645606046 39.7166;12.9315;24.3655;31.8111;10.6089;23.3972;31.9826;46.2316 22.6911;8.91033;19.538;24.7342;2.59129;18.3088;24.4836;31.1788 60.0334;23.4636;32.1467;44.3296;37.5078;31.9156;45.5891;81.7848 0 Exp 2,5(0.36);Exp 3,1(0.08);Hill,1(0.08);Linear,3(0.22);Poly 2,4(0.29) 1.9298115754994192 27.37120509147644 1.5461770296096802 2.6703107357025146 0.339875057558844 1.8304733633995056 27.305285176914644 53.50878625165678 19.370763030527225 34.05959696947277 43.053831989414824 69.20606801058517 CONFLICT 0.42857142857142855 0.5714285714285714 0.0 GO:0009887 4 animal organ morphogenesis 110 116 5 5 4 4 3 3 159 113 2272 0.054259 0.98249 0.11554 2.59 65164;294515;29496 htra1;foxo3;erbb3 HTRA1_8856;FOXO3_8662;ERBB3_8571 35.77663333333333 33.1323 13.1992 24.00906608436349 41.9791519077541 20.386557995589236 24.2995 25.6145 5.6804 17.997666329555067 29.720285832739524 13.994979635029114 64.46433333333333 46.6629 32.7581 43.43492442543597 71.94271549523872 42.27519337765754 33.1323;13.1992;60.9984 25.6145;5.6804;41.6036 46.6629;32.7581;113.972 1 2 1 29496 ERBB3_8571 60.9984 60.9984 41.6036 41.6036 113.972 113.972 60.9984 41.6036 113.972 2 65164;294515 HTRA1_8856;FOXO3_8662 23.16575 23.16575 14.094830180069573 15.64745 15.64745 14.095537286850758 39.710499999999996 39.710499999999996 9.832178371042746 33.1323;13.1992 25.6145;5.6804 46.6629;32.7581 0 Exp 4,1(0.34);Linear,2(0.67) 1.7063119307311974 5.149954080581665 1.5603101253509521 1.9883413314819336 0.2361814484778559 1.6013026237487793 8.607817430407732 62.94544923625894 3.9332232996987884 44.665776700301215 15.313089327190582 113.61557733947608 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0051186 4 cofactor metabolic process 111 126 27 27 16 24 14 14 148 112 2273 0.98786 0.026459 0.036702 11.11 25106;293656;298490;100359982;25675;81869;57298;29328;83842;192272;170570;50559;170465;296925 rgn;rgd1307603;ppcs;mpc2;hmgcr;gstm7;gstm3l;gpx4;crot;acot2;acot12;acot1;acaa2;aass RGN_9699;RGD1307603_9684;PPCS_9540;MPC2_33219;HMGCR_8810;GSTM7_8761;GSTM3_8760;GPX4_32827;CROT_8384;ACOT2_7969;ACOT12_32718;ACOT1_7968;ACAA2_7955;AASS_7936 33.84926714285714 30.77205 1.63089 22.359887699655197 36.91293592277797 19.462875790296373 25.87276192857143 25.09615 0.663137 16.28757418807776 28.599259649941548 13.911877328198326 49.29959285714285 39.187200000000004 7.6286 36.15285145844101 51.98940291004455 31.86332576538195 5.5 28.903350000000003 11.5 59.9712 77.4407;34.7372;20.3353;46.8463;1.63089;42.3152;73.0961;45.9204;7.4229;8.54905;30.3423;31.2018;26.5872;27.4644 58.7732;26.1766;16.7643;35.8494;0.663137;31.4035;51.4219;34.2198;5.75707;7.19676;24.0157;26.858;21.3695;21.7498 89.8047;50.9085;25.6711;69.127;7.6286;64.5991;140.853;70.4292;10.316;10.4125;41.1025;37.2719;35.0407;37.0295 12 2 12 25106;298490;100359982;81869;57298;29328;83842;192272;170570;50559;170465;296925 RGN_9699;PPCS_9540;MPC2_33219;GSTM7_8761;GSTM3_8760;GPX4_32827;CROT_8384;ACOT2_7969;ACOT12_32718;ACOT1_7968;ACAA2_7955;AASS_7936 36.4601375 30.77205 22.113195432295054 27.948244166666665 25.43685 15.844118275639795 52.63810000000001 39.187200000000004 37.073103340537614 77.4407;20.3353;46.8463;42.3152;73.0961;45.9204;7.4229;8.54905;30.3423;31.2018;26.5872;27.4644 58.7732;16.7643;35.8494;31.4035;51.4219;34.2198;5.75707;7.19676;24.0157;26.858;21.3695;21.7498 89.8047;25.6711;69.127;64.5991;140.853;70.4292;10.316;10.4125;41.1025;37.2719;35.0407;37.0295 2 293656;25675 RGD1307603_9684;HMGCR_8810 18.184045 18.184045 23.409696301064013 13.4198685 13.4198685 18.040742698852075 29.268549999999998 29.268549999999998 30.603510779075656 34.7372;1.63089 26.1766;0.663137 50.9085;7.6286 0 Exp 2,8(0.58);Exp 4,1(0.08);Linear,3(0.22);Poly 2,2(0.15) 3.5076369346830765 383.97592782974243 1.547789216041565 344.14306640625 91.19905262368542 1.9255954027175903 22.136441685818056 45.56209259989623 17.340808810288472 34.40471504685439 30.36157113740451 68.23761457688121 UP 0.8571428571428571 0.14285714285714285 0.0 GO:2000113 8 negative regulation of cellular macromolecule biosynthetic process 254 266 19 19 15 17 14 14 148 252 2133 0.26643 0.8167 0.50791 5.26 79426;24522;246273;25106;24516;25112;294515;24890;116636;24330;25695;114851;29184;79431 zfp36;zfp354a;trib3;rgn;jun;gadd45a;foxo3;esr1;eif4ebp1;egr1;cebpd;cdkn1a;cd36;bhlhe40 ZFP36_10204;ZFP354A_10203;TRIB3_10079;RGN_9699;JUN_8938;GADD45A_8678;FOXO3_8662;ESR1_33192;EIF4EBP1_8550;EGR1_8533;CEBPD_8283;CDKN1A_8271;CD36_8243;BHLHE40_8141 38.55573457142857 19.9148 0.306936 40.36877889873543 40.04668341603397 42.38378221750695 27.719218228571428 14.415600000000001 0.0732342 31.51068866209038 29.439186104251213 33.74833203200134 54.99799714285714 36.34355 1.15962 49.7889385663273 54.10326059006376 49.95622319443886 12.5 105.4915 0.348134;0.834827;108.064;77.4407;16.4324;102.919;13.1992;23.3972;83.9001;0.750017;0.306936;6.24967;48.1296;57.8085 0.118102;0.27095;83.8836;58.7732;10.5224;89.5012;5.6804;18.3088;42.4185;0.186019;0.0732342;2.44025;37.5433;38.3491 1.15962;2.99857;143.428;89.8047;39.929;115.437;32.7581;31.9156;107.32;4.70178;1.73689;19.0606;69.1421;110.58 3 11 3 25106;116636;29184 RGN_9699;EIF4EBP1_8550;CD36_8243 69.82346666666666 77.4407 19.06302311553273 46.245000000000005 42.4185 11.12019515071562 88.7556 89.8047 19.110559128659766 77.4407;83.9001;48.1296 58.7732;42.4185;37.5433 89.8047;107.32;69.1421 11 79426;24522;246273;24516;25112;294515;24890;24330;25695;114851;79431 ZFP36_10204;ZFP354A_10203;TRIB3_10079;JUN_8938;GADD45A_8678;FOXO3_8662;ESR1_33192;EGR1_8533;CEBPD_8283;CDKN1A_8271;BHLHE40_8141 30.028171272727274 13.1992 40.896912379032344 22.666732290909092 5.6804 33.69016249991778 45.79137818181818 31.9156 52.10054212219539 0.348134;0.834827;108.064;16.4324;102.919;13.1992;23.3972;0.750017;0.306936;6.24967;57.8085 0.118102;0.27095;83.8836;10.5224;89.5012;5.6804;18.3088;0.186019;0.0732342;2.44025;38.3491 1.15962;2.99857;143.428;39.929;115.437;32.7581;31.9156;4.70178;1.73689;19.0606;110.58 0 Exp 2,3(0.22);Exp 3,1(0.08);Exp 4,2(0.15);Hill,4(0.29);Poly 2,4(0.29) 2.1148300922068106 31.579630613327026 1.522104263305664 4.591650485992432 0.9670017589662461 1.9076563715934753 17.409275004818923 59.70219413803821 11.212910089293228 44.22552636784964 28.916956175570594 81.0790381101437 DOWN 0.21428571428571427 0.7857142857142857 0.0 GO:0042755 4 eating behavior 5 6 2 2 2 2 2 2 160 4 2381 0.99562 0.050905 0.050905 33.33 29455;29184 gdf15;cd36 GDF15_33113;CD36_8243 76.6393 76.6393 48.1296 40.31880439918822 73.40020995995997 40.05774057039447 61.446 61.446 37.5433 33.80352251733537 58.730327877877876 33.58464506929106 97.39705000000001 97.39705000000001 69.1421 39.958533494173636 94.18690302802803 39.69980241565043 0.0 48.1296 0.0 48.1296 105.149;48.1296 85.3487;37.5433 125.652;69.1421 1 1 1 29184 CD36_8243 48.1296 48.1296 37.5433 37.5433 69.1421 69.1421 48.1296 37.5433 69.1421 1 29455 GDF15_33113 105.149 105.149 85.3487 85.3487 125.652 125.652 105.149 85.3487 125.652 0 Exp 2,1(0.5);Poly 2,1(0.5) 2.0414050254071805 4.230928540229797 1.5606178045272827 2.6703107357025146 0.7846713966687833 2.1154642701148987 20.760288000000017 132.51831199999998 14.596708000000007 108.29529199999999 42.017348000000005 152.77675200000002 CONFLICT 0.5 0.5 0.0 GO:0000165 8 MAPK cascade 43 45 4 4 3 3 2 2 160 43 2342 0.44639 0.79187 1.0 4.44 79426;24825 zfp36;tf ZFP36_10204;TF_10003 22.751017 22.751017 0.348134 31.68246097485765 34.06331613962995 27.346701990814797 14.125051000000001 14.125051000000001 0.118102 19.808817243268262 21.197836994621344 17.097971725493597 31.34686 31.34686 1.15962 42.691204218611595 46.58985747848538 36.84889378769703 0.348134;45.1539 0.118102;28.132 1.15962;61.5341 1 1 1 24825 TF_10003 45.1539 45.1539 28.132 28.132 61.5341 61.5341 45.1539 28.132 61.5341 1 79426 ZFP36_10204 0.348134 0.348134 0.118102 0.118102 1.15962 1.15962 0.348134 0.118102 1.15962 0 Hill,1(0.5);Poly 2,1(0.5) 1.8856110529437873 3.772647738456726 1.8344712257385254 1.9381765127182007 0.07333071166822537 1.886323869228363 -21.158633679999998 66.66066768 -13.328569039999996 41.578671039999996 -27.8201304 90.51385040000001 CONFLICT 0.5 0.5 0.0 GO:0043068 7 positive regulation of programmed cell death 198 213 20 20 18 17 15 15 147 198 2187 0.72453 0.37755 0.6595 7.04 24794;83516;24314;24516;63868;25675;299626;25112;289388;294515;24330;116663;25423;114851;246142 serpina3c;ppargc1a;nqo1;jun;hspd1;hmgcr;gadd45b;gadd45a;g0s2;foxo3;egr1;dusp6;ctsc;cdkn1a;bmf SERPINA3C_32925;PPARGC1A_33189;NQO1_33055;JUN_8938;HSPD1_8849;HMGCR_8810;GADD45B_8679;GADD45A_8678;G0S2_32729;FOXO3_8662;EGR1_8533;DUSP6_8506;CTSC_32456;CDKN1A_8271;BMF_8152 47.27633846666666 42.4094 0.750017 36.99686292972197 50.745712214466614 37.59446847765578 32.01864706666667 26.2988 0.186019 27.435590966929386 36.53519660476927 30.95830771867792 78.04653866666666 81.7305 4.70178 53.834945916334995 78.542808262173 46.22609013997485 9.5 59.316 29.766;42.4094;87.2765;16.4324;42.2579;1.63089;106.367;102.919;46.3784;13.1992;0.750017;62.3934;56.2386;6.24967;94.8767 23.347;26.2988;60.6992;10.5224;23.9469;0.663137;52.7132;89.5012;33.7914;5.6804;0.186019;39.0875;38.2681;2.44025;73.1342 40.8256;81.7305;197.117;39.929;102.383;7.6286;109.434;115.437;73.6529;32.7581;4.70178;133.304;102.888;19.0606;109.848 5 10 5 24314;63868;299626;289388;246142 NQO1_33055;HSPD1_8849;GADD45B_8679;G0S2_32729;BMF_8152 75.4313 87.2765 29.24036313326155 48.85698 52.7132 19.94978574125548 118.48697999999999 109.434 46.39154386525632 87.2765;42.2579;106.367;46.3784;94.8767 60.6992;23.9469;52.7132;33.7914;73.1342 197.117;102.383;109.434;73.6529;109.848 10 24794;83516;24516;25675;25112;294515;24330;116663;25423;114851 SERPINA3C_32925;PPARGC1A_33189;JUN_8938;HMGCR_8810;GADD45A_8678;FOXO3_8662;EGR1_8533;DUSP6_8506;CTSC_32456;CDKN1A_8271 33.1988577 23.0992 32.994091804834795 23.5994806 16.9347 27.526787760236324 57.826318 40.377300000000005 46.786036072430804 29.766;42.4094;16.4324;1.63089;102.919;13.1992;0.750017;62.3934;56.2386;6.24967 23.347;26.2988;10.5224;0.663137;89.5012;5.6804;0.186019;39.0875;38.2681;2.44025 40.8256;81.7305;39.929;7.6286;115.437;32.7581;4.70178;133.304;102.888;19.0606 0 Exp 2,4(0.27);Exp 3,1(0.07);Exp 4,3(0.2);Hill,1(0.07);Linear,2(0.14);Poly 2,3(0.2);Power,1(0.07) 1.8738393062045402 29.197854042053223 1.522104263305664 4.21828556060791 0.6751344048159176 1.701177716255188 28.553342558805713 65.9993343745276 18.134322377318586 45.90297175601475 50.802297066882204 105.29078026645115 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0098656 6 anion transmembrane transport 47 47 6 5 5 5 4 4 158 43 2342 0.82445 0.35007 0.53836 8.51 29573;29482;100359982;140668 slc37a4;slc1a2;mpc2;abcc3 SLC37A4_9871;SLC1A2_33059;MPC2_33219;ABCC3_7941 34.400975 38.71705 13.3235 14.58768057811681 34.54490784736587 14.006098871529954 24.63768 26.7959 9.10952 11.688185082392687 24.01764998195502 11.040458279451945 50.69265 54.483149999999995 24.6773 19.209112647994253 51.125796593459796 18.509639753062306 1.5 38.71705 39.7166;13.3235;46.8463;37.7175 22.6911;9.10952;35.8494;30.9007 60.0334;24.6773;69.127;48.9329 2 2 2 100359982;140668 MPC2_33219;ABCC3_7941 42.2819 42.2819 6.455036384095749 33.37505 33.37505 3.4992593280578927 59.02995 59.02995 14.279385049959226 46.8463;37.7175 35.8494;30.9007 69.127;48.9329 2 29573;29482 SLC37A4_9871;SLC1A2_33059 26.520049999999998 26.520049999999998 18.66273998653467 15.90031 15.90031 9.60362731722759 42.35535 42.35535 25.000538066309673 39.7166;13.3235 22.6911;9.10952 60.0334;24.6773 0 Exp 2,2(0.5);Poly 2,2(0.5) 2.05747060016348 8.474441409111023 1.620316982269287 3.0381598472595215 0.6279624414342218 1.9079822897911072 20.105048033445513 48.69690196655448 13.18325861925518 36.09210138074482 31.86771960496562 69.51758039503437 CONFLICT 0.5 0.5 0.0 GO:0072593 4 reactive oxygen species metabolic process 40 44 4 4 4 4 4 4 158 40 2345 0.85591 0.30563 0.35972 9.09 29441;24314;140942;497840 por;nqo1;ddit4;cps1 POR_9531;NQO1_33055;DDIT4_8450;CPS1_32421 54.81065 59.62955 12.4414 38.47792634611001 35.01739564102564 31.988605563330225 36.7294775 38.86445 8.48981 24.45921997825547 24.16008379959514 20.23417000629725 141.8584 138.17624999999998 45.5891 94.83818086583064 96.25029045883939 79.26956815633065 1.5 59.62955 12.4414;87.2765;87.5421;31.9826 8.48981;60.6992;53.2453;24.4836 79.2355;197.117;245.492;45.5891 1 3 1 24314 NQO1_33055 87.2765 87.2765 60.6992 60.6992 197.117 197.117 87.2765 60.6992 197.117 3 29441;140942;497840 POR_9531;DDIT4_8450;CPS1_32421 43.9887 31.9826 38.96329828222965 28.73957 24.4836 22.679251128855647 123.43886666666667 79.2355 107.03151673971239 12.4414;87.5421;31.9826 8.48981;53.2453;24.4836 79.2355;245.492;45.5891 0 Exp 2,2(0.5);Linear,1(0.25);Poly 2,1(0.25) 1.7563570411340466 7.052350640296936 1.576730489730835 1.9819281101226807 0.17872644617152528 1.7468460202217102 17.102282180812196 92.51901781918781 12.75944192130964 60.69951307869036 48.91698275148599 234.799817248514 DOWN 0.25 0.75 0.0 GO:0050804 6 modulation of chemical synaptic transmission 117 127 7 6 4 6 4 4 158 123 2262 0.082604 0.96737 0.18745 3.15 85253;24957;24330;79431 plg;glul;egr1;bhlhe40 PLG_9501;GLUL_32832;EGR1_8533;BHLHE40_8141 38.952779250000006 42.1377 0.750017 31.53950577003052 38.51301107047013 34.7976643101724 26.45407975 29.69735 0.186019 20.429249610308915 25.909646744025462 22.613348826503064 75.32277 73.00515 4.70178 67.04552138253233 77.31317796082273 74.58114692214774 70.7857;26.4669;0.750017;57.8085 46.2356;21.0456;0.186019;38.3491 150.579;35.4303;4.70178;110.58 0 4 0 4 85253;24957;24330;79431 PLG_9501;GLUL_32832;EGR1_8533;BHLHE40_8141 38.952779250000006 42.1377 31.53950577003052 26.45407975 29.69735 20.429249610308915 75.32277 73.00515 67.04552138253233 70.7857;26.4669;0.750017;57.8085 46.2356;21.0456;0.186019;38.3491 150.579;35.4303;4.70178;110.58 0 Exp 2,1(0.25);Hill,1(0.25);Linear,2(0.5) 2.255883709819994 9.809742331504822 1.5254690647125244 4.21828556060791 1.2310153229975307 2.0329938530921936 8.04406359537008 69.86149490462992 6.4334151318972665 46.47474436810273 9.61815904511829 141.0273809548817 DOWN 0.0 1.0 0.0 GO:0046209 5 nitric oxide metabolic process 7 10 2 2 2 2 2 2 160 8 2377 0.97825 0.12934 0.12934 20.0 29441;497840 por;cps1 POR_9531;CPS1_32421 22.212 22.212 12.4414 13.817715032522564 21.832463097449754 13.80728619965579 16.486705 16.486705 8.48981 11.309317365873593 16.1760672952204 11.300781730251613 62.4123 62.4123 45.5891 23.791597602515044 63.06579366661037 23.77364104497668 0.0 12.4414 0.0 12.4414 12.4414;31.9826 8.48981;24.4836 79.2355;45.5891 0 2 0 2 29441;497840 POR_9531;CPS1_32421 22.212 22.212 13.817715032522564 16.486705 16.486705 11.309317365873593 62.4123 62.4123 23.791597602515044 12.4414;31.9826 8.48981;24.4836 79.2355;45.5891 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.9026148159840934 3.8084036111831665 1.8264755010604858 1.9819281101226807 0.10992159402101931 1.9042018055915833 3.061624000000002 41.362376000000005 0.8127908000000037 32.1606192 29.438828000000008 95.385772 DOWN 0.0 1.0 0.0 GO:0022610 2 biological adhesion 150 155 7 7 5 6 5 5 157 150 2235 0.060559 0.9751 0.12406 3.23 307582;63868;25661;361969;29184 lama3;hspd1;fn1;fga;cd36 LAMA3_8980;HSPD1_8849;FN1_8655;FGA_8632;CD36_8243 36.202946 42.2579 2.46923 21.916631785862545 42.27335158669872 17.446420870172286 23.1881202 23.9469 0.871501 13.846664286523673 27.268930339608723 10.249315788868591 65.20734 69.1421 10.4175 40.91742922793414 72.94413361385867 35.12021729620945 2.46923;42.2579;59.5777;28.5803;48.1296 0.871501;23.9469;31.0499;22.529;37.5433 10.4175;102.383;105.243;38.8511;69.1421 2 3 2 63868;29184 HSPD1_8849;CD36_8243 45.19375 45.19375 4.151918887092963 30.7451 30.7451 9.61410663972478 85.76255 85.76255 23.504865802743858 42.2579;48.1296 23.9469;37.5433 102.383;69.1421 3 307582;25661;361969 LAMA3_8980;FN1_8655;FGA_8632 30.209076666666665 28.5803 28.589054225483455 18.150133666666665 22.529 15.558431615195033 51.50386666666666 38.8511 48.662493162633304 2.46923;59.5777;28.5803 0.871501;31.0499;22.529 10.4175;105.243;38.8511 0 Exp 2,1(0.2);Exp 3,1(0.2);Exp 4,1(0.2);Linear,1(0.2);Power,1(0.2) 1.945657377225588 9.933507680892944 1.541895866394043 2.6703107357025146 0.46540942871600843 1.7792335748672485 16.99217122367968 55.41372077632033 11.050983818336059 35.32525658166394 29.341631938466584 101.07304806153343 DOWN 0.4 0.6 0.0 GO:0045428 5 regulation of nitric oxide biosynthetic process 33 36 4 4 4 4 4 4 158 32 2353 0.92544 0.19254 0.28483 11.11 25106;24890;29184;25698 rgn;esr1;cd36;ass1 RGN_9699;ESR1_33192;CD36_8243;ASS1_33159 43.942800000000005 37.46665 23.3972 24.86972072501015 47.657031126754 22.40390924915421 33.90195 29.262900000000002 18.3088 18.635960055852596 36.80264026851895 16.747142677336207 56.892625 52.9251 31.9156 27.47435862707565 62.65577943685608 24.455838765281264 0.5 25.100450000000002 2.5 62.78515 77.4407;23.3972;48.1296;26.8037 58.7732;18.3088;37.5433;20.9825 89.8047;31.9156;69.1421;36.7081 2 2 2 25106;29184 RGN_9699;CD36_8243 62.78515 62.78515 20.726077574037024 48.15825 48.15825 15.0118062539123 79.4734 79.4734 14.610664576945227 77.4407;48.1296 58.7732;37.5433 89.8047;69.1421 2 24890;25698 ESR1_33192;ASS1_33159 25.100450000000002 25.100450000000002 2.408759250111924 19.645650000000003 19.645650000000003 1.890591400858429 34.31185 34.31185 3.3888092488365134 23.3972;26.8037 18.3088;20.9825 31.9156;36.7081 0 Exp 2,3(0.75);Poly 2,1(0.25) 2.1421539149918445 8.708613276481628 1.7198865413665771 2.6703107357025146 0.44991209456538256 2.1592079997062683 19.570473689490036 68.31512631050995 15.638709145264468 52.16519085473554 29.96775354546585 83.81749645453414 CONFLICT 0.5 0.5 0.0 GO:0070328 8 triglyceride homeostasis 18 18 4 4 2 4 2 2 160 16 2369 0.89794 0.31912 0.31912 11.11 24539;25675 lpl;hmgcr LPL_32544;HMGCR_8810 37.917494999999995 37.917494999999995 1.63089 51.31700892347536 66.03235655399999 32.44294259852021 25.2656685 25.2656685 0.663137 34.793233716011294 44.3277099062 21.996505796912807 81.52680000000001 81.52680000000001 7.6286 104.50783667495946 138.78312536 66.07052549374521 0.0 1.63089 0.5 37.917494999999995 74.2041;1.63089 49.8682;0.663137 155.425;7.6286 1 1 1 24539 LPL_32544 74.2041 74.2041 49.8682 49.8682 155.425 155.425 74.2041 49.8682 155.425 1 25675 HMGCR_8810 1.63089 1.63089 0.663137 0.663137 7.6286 7.6286 1.63089 0.663137 7.6286 0 Exp 2,1(0.5);Exp 4,1(0.5) 1.7220971687897821 3.4611692428588867 1.559399127960205 1.9017701148986816 0.24209284654572766 1.7305846214294434 -33.20425079999999 109.03924079999999 -22.95529324 73.48663024 -63.313672 226.367272 CONFLICT 0.5 0.5 0.0 GO:0050806 6 positive regulation of synaptic transmission 48 51 3 2 2 2 2 2 160 49 2336 0.35991 0.84641 0.76928 3.92 24957;24330 glul;egr1 GLUL_32832;EGR1_8533 13.6084585 13.6084585 0.750017 18.184582360281045 11.16015317582314 17.85190851693619 10.615809500000001 10.615809500000001 0.186019 14.749951177810061 8.629930292850423 14.480111439384794 20.06604 20.06604 4.70178 21.728344867826458 17.14061551834431 21.33084044053256 26.4669;0.750017 21.0456;0.186019 35.4303;4.70178 0 2 0 2 24957;24330 GLUL_32832;EGR1_8533 13.6084585 13.6084585 18.184582360281045 10.615809500000001 10.615809500000001 14.749951177810061 20.06604 20.06604 21.728344867826458 26.4669;0.750017 21.0456;0.186019 35.4303;4.70178 0 Hill,1(0.5);Linear,1(0.5) 3.1566933374622246 6.580551624298096 2.3622660636901855 4.21828556060791 1.3124039722849674 3.290275812149048 -11.594086840000001 38.81100384 -9.826579879999997 31.05819888 -10.0479096 50.1799896 DOWN 0.0 1.0 0.0 GO:0062013 6 positive regulation of small molecule metabolic process 62 68 9 9 7 7 5 5 157 63 2322 0.73804 0.43714 0.61819 7.35 25106;83516;29441;24360;25428 rgn;ppargc1a;por;fabp1;cyp7a1 RGN_9699;PPARGC1A_33189;POR_9531;FABP1_33091;CYP7A1_8430 34.372116000000005 33.8478 5.72128 28.37958102624631 38.65073291207383 26.759116347484753 24.204136600000002 26.2988 0.985273 22.308148234464305 27.72596861099718 20.7592601304599 64.01178 79.2355 22.3625 28.44989483938386 72.03734116893105 21.371303146226374 2.5 38.1286 77.4407;42.4094;12.4414;33.8478;5.72128 58.7732;26.2988;8.48981;26.4736;0.985273 89.8047;81.7305;79.2355;46.9257;22.3625 2 3 2 25106;24360 RGN_9699;FABP1_33091 55.64425 55.64425 30.824835201587067 42.623400000000004 42.623400000000004 22.839266189613 68.3652 68.3652 30.32003167049796 77.4407;33.8478 58.7732;26.4736 89.8047;46.9257 3 83516;29441;25428 PPARGC1A_33189;POR_9531;CYP7A1_8430 20.190693333333332 12.4414 19.53313076949349 11.924627666666666 8.48981 13.001620729638532 61.109500000000004 79.2355 33.57906733368275 42.4094;12.4414;5.72128 26.2988;8.48981;0.985273 81.7305;79.2355;22.3625 0 Exp 2,2(0.4);Hill,1(0.2);Poly 2,2(0.4) 2.197445138497317 11.895109176635742 1.7198865413665771 4.560328960418701 1.2237312652802057 1.8753424882888794 9.496316439721195 59.2479155602788 4.650182525473589 43.75809067452641 39.074347665075564 88.94921233492444 DOWN 0.4 0.6 0.0 GO:0044260 4 cellular macromolecule metabolic process 676 733 45 45 34 40 30 30 132 703 1682 0.0013769 0.99929 0.0022698 4.09 79426;312688;246273;24825;29573;293615;29676;192280;29441;303612;25513;81819;25591;24516;364070;63868;24957;499914;294515;314322;25661;308441;24890;29496;171142;24330;116663;29184;25377;24158 zfp36;usp18;trib3;tf;slc37a4;sirt3;psmb3;ppp1r3b;por;polg2;pik3r1;pax8;parp1;jun;iars2;hspd1;glul;gins1;foxo3;fos;fn1;exosc5;esr1;erbb3;ehhadh;egr1;dusp6;cd36;ambp;acadm ZFP36_10204;USP18_10138;TRIB3_10079;TF_10003;SLC37A4_9871;SIRT3_9828;PSMB3_9589;PPP1R3B_9545;POR_9531;POLG2_9521;PIK3R1_32562;PAX8_9432;PARP1_9425;JUN_8938;IARS2_8858;HSPD1_8849;GLUL_32832;GINS1_8707;FOXO3_8662;FOS_8657;FN1_8655;EXOSC5_32543;ESR1_33192;ERBB3_8571;EHHADH_8534;EGR1_8533;DUSP6_8506;CD36_8243;AMBP_33085;ACADM_7957 35.33503736666671 26.7205 1.28141E-12 28.415615972972926 38.55273906212521 26.24224616800862 24.597476033333372 21.4223 1.28141E-12 20.248868224954233 26.599137871802355 18.694086428346903 59.154225666666704 47.6111 1.28142E-12 43.87841706762534 64.86099395019937 41.254753007090905 0.348134;108.883;108.064;45.1539;39.7166;2.38018;23.7888;36.1411;12.4414;63.7758;18.7324;56.8931;26.9741;16.4324;24.7304;42.2579;26.4669;58.9165;13.1992;1.28141E-12;59.5777;41.9329;23.3972;60.9984;8.62809;0.750017;62.3934;48.1296;17.2343;11.7137 0.118102;73.1414;83.8836;28.132;22.6911;0.56209;19.2724;27.0588;8.48981;40.9553;11.6701;45.1162;21.799;10.5224;19.8021;23.9469;21.0456;44.7208;5.6804;1.28141E-12;31.0499;31.7336;18.3088;41.6036;7.31865;0.186019;39.0875;37.5433;14.1233;8.36151 1.15962;138.144;143.428;61.5341;60.0334;8.82917;30.901;53.6244;79.2355;132.567;41.5978;81.5688;35.2797;39.929;32.7087;102.383;35.4303;91.837;32.7581;1.28142E-12;105.243;62.1373;31.9156;113.972;10.3909;4.70178;133.304;69.1421;21.9073;18.9642 14 16 14 312688;24825;293615;29676;81819;25591;364070;63868;499914;308441;29496;171142;29184;24158 USP18_10138;TF_10003;SIRT3_9828;PSMB3_9589;PAX8_9432;PARP1_9425;IARS2_8858;HSPD1_8849;GINS1_8707;EXOSC5_32543;ERBB3_8571;EHHADH_8534;CD36_8243;ACADM_7957 40.09861214285714 42.0954 27.450042130588983 28.789539285714284 26.039450000000002 18.925241502633654 61.270855 61.8357 40.50507092663693 108.883;45.1539;2.38018;23.7888;56.8931;26.9741;24.7304;42.2579;58.9165;41.9329;60.9984;8.62809;48.1296;11.7137 73.1414;28.132;0.56209;19.2724;45.1162;21.799;19.8021;23.9469;44.7208;31.7336;41.6036;7.31865;37.5433;8.36151 138.144;61.5341;8.82917;30.901;81.5688;35.2797;32.7087;102.383;91.837;62.1373;113.972;10.3909;69.1421;18.9642 16 79426;246273;29573;192280;29441;303612;25513;24516;24957;294515;314322;25661;24890;24330;116663;25377 ZFP36_10204;TRIB3_10079;SLC37A4_9871;PPP1R3B_9545;POR_9531;POLG2_9521;PIK3R1_32562;JUN_8938;GLUL_32832;FOXO3_8662;FOS_8657;FN1_8655;ESR1_33192;EGR1_8533;DUSP6_8506;AMBP_33085 31.16690943750008 21.064799999999998 29.46721507250268 20.92942068750008 16.216050000000003 21.249376005798638 57.30217500000008 40.763400000000004 47.88037585718717 0.348134;108.064;39.7166;36.1411;12.4414;63.7758;18.7324;16.4324;26.4669;13.1992;1.28141E-12;59.5777;23.3972;0.750017;62.3934;17.2343 0.118102;83.8836;22.6911;27.0588;8.48981;40.9553;11.6701;10.5224;21.0456;5.6804;1.28141E-12;31.0499;18.3088;0.186019;39.0875;14.1233 1.15962;143.428;60.0334;53.6244;79.2355;132.567;41.5978;39.929;35.4303;32.7581;1.28142E-12;105.243;31.9156;4.70178;133.304;21.9073 0 Exp 2,12(0.4);Exp 3,1(0.04);Exp 4,1(0.04);Hill,4(0.14);Linear,3(0.1);Poly 2,7(0.24);Power,2(0.07) 2.076986915493753 88.85957753658295 1.5209722518920898 32.73371124267578 5.646072647314834 1.8215704560279846 25.16663978218314 45.50343495115028 17.35151159803879 31.843440468627968 43.45253577383542 74.85591555949799 CONFLICT 0.4666666666666667 0.5333333333333333 0.0 GO:0060316 12 positive regulation of ryanodine-sensitive calcium-release channel activity 3 3 1 1 1 1 1 1 161 2 2383 0.98844 0.179 0.179 33.33 81869 gstm7 GSTM7_8761 42.3152 42.3152 42.3152 42.3152 31.4035 31.4035 31.4035 31.4035 64.5991 64.5991 64.5991 64.5991 0.0 42.3152 0.0 42.3152 42.3152 31.4035 64.5991 1 0 1 81869 GSTM7_8761 42.3152 42.3152 31.4035 31.4035 64.5991 64.5991 42.3152 31.4035 64.5991 0 0 Linear,1(1) 1.7501527070999146 1.7501527070999146 1.7501527070999146 1.7501527070999146 0.0 1.7501527070999146 42.3152 42.3152 31.4035 31.4035 64.5991 64.5991 UP 1.0 0.0 0.0 GO:1902109 8 negative regulation of mitochondrial membrane permeability involved in apoptotic process 4 4 1 1 1 1 1 1 161 3 2382 0.97784 0.23128 0.23128 25.0 170465 acaa2 ACAA2_7955 26.5872 26.5872 26.5872 26.587199999999996 21.3695 21.3695 21.3695 21.3695 35.0407 35.0407 35.0407 35.0407 0.0 26.5872 0.0 26.5872 26.5872 21.3695 35.0407 1 0 1 170465 ACAA2_7955 26.5872 26.5872 21.3695 21.3695 35.0407 35.0407 26.5872 21.3695 35.0407 0 0 Exp 2,1(1) 2.8333094120025635 2.8333094120025635 2.8333094120025635 2.8333094120025635 0.0 2.8333094120025635 26.5872 26.5872 21.3695 21.3695 35.0407 35.0407 UP 1.0 0.0 0.0 GO:0007093 7 mitotic cell cycle checkpoint 35 38 4 4 3 3 2 2 160 36 2349 0.56102 0.70748 1.0 5.26 257644;114851 zwint;cdkn1a ZWINT_10214;CDKN1A_8271 29.124985000000002 29.124985000000002 6.24967 32.35058071655669 16.34644277618924 26.83240186727646 20.670875 20.670875 2.44025 25.781997125538005 10.486936054068105 21.38425006569819 49.96095 49.96095 19.0606 43.699694052075465 32.69948596308812 36.24564772286178 0.5 29.124985000000002 52.0003;6.24967 38.9015;2.44025 80.8613;19.0606 1 1 1 257644 ZWINT_10214 52.0003 52.0003 38.9015 38.9015 80.8613 80.8613 52.0003 38.9015 80.8613 1 114851 CDKN1A_8271 6.24967 6.24967 2.44025 2.44025 19.0606 19.0606 6.24967 2.44025 19.0606 0 Exp 2,1(0.5);Exp 4,1(0.5) 1.5214481131583526 3.0428965091705322 1.5207922458648682 1.522104263305664 9.277364294217994E-4 1.5214482545852661 -15.710632399999994 73.9606024 -15.061150000000001 56.4029 -10.603735999999998 110.52563599999999 CONFLICT 0.5 0.5 0.0 GO:0090090 8 negative regulation of canonical Wnt signaling pathway 23 23 2 2 2 2 2 2 160 21 2364 0.82335 0.43545 0.65454 8.7 294515;24330 foxo3;egr1 FOXO3_8662;EGR1_8533 6.9746084999999995 6.9746084999999995 0.750017 8.802901719532288 3.462984815698393 7.268292570022791 2.9332095 2.9332095 0.186019 3.885114063522524 1.383372980593325 3.2078224409725835 18.72994 18.72994 4.70178 19.838814127139756 10.815907584672434 16.38031525427667 0.5 6.9746084999999995 13.1992;0.750017 5.6804;0.186019 32.7581;4.70178 0 2 0 2 294515;24330 FOXO3_8662;EGR1_8533 6.9746084999999995 6.9746084999999995 8.802901719532288 2.9332095 2.9332095 3.885114063522524 18.72994 18.72994 19.838814127139756 13.1992;0.750017 5.6804;0.186019 32.7581;4.70178 0 Exp 4,1(0.5);Hill,1(0.5) 2.8960993643433826 6.206626892089844 1.9883413314819336 4.21828556060791 1.5768086860827863 3.103313446044922 -5.225590839999998 19.174807839999996 -2.4512838799999996 8.317702879999999 -8.765253599999998 46.22513359999999 DOWN 0.0 1.0 0.0 GO:0046688 6 response to copper ion 25 27 2 2 2 2 2 2 160 25 2360 0.75576 0.5205 0.6885 7.41 24567;24158 mt1;acadm MT1A_9255;ACADM_7957 12.3226 12.3226 11.7137 0.8611146381289974 12.151294455922866 0.8263336137038307 8.63592 8.63592 8.36151 0.3880743436507997 8.558718564049586 0.37239974862291025 21.213900000000002 21.213900000000002 18.9642 3.1815562512707203 20.58097820247934 3.053050961979903 0.5 12.3226 12.9315;11.7137 8.91033;8.36151 23.4636;18.9642 1 1 1 24158 ACADM_7957 11.7137 11.7137 8.36151 8.36151 18.9642 18.9642 11.7137 8.36151 18.9642 1 24567 MT1A_9255 12.9315 12.9315 8.91033 8.91033 23.4636 23.4636 12.9315 8.91033 23.4636 0 Poly 2,2(1) 1.961881189578811 3.966444969177246 1.693061113357544 2.273383855819702 0.4103501464717665 1.983222484588623 11.129155999999998 13.516044 8.098076400000002 9.1737636 16.804488000000006 25.623312 CONFLICT 0.5 0.5 0.0 GO:0042176 6 regulation of protein catabolic process 106 112 5 5 5 4 4 4 158 108 2277 0.14731 0.93508 0.31835 3.57 246273;25106;25675;25423 trib3;rgn;hmgcr;ctsc TRIB3_10079;RGN_9699;HMGCR_8810;CTSC_32456 60.8435475 66.83965 1.63089 44.84261721139491 70.45847797563677 30.770833153607647 45.397009249999996 48.52065 0.663137 35.17613215478373 51.9671284475083 25.40502109951253 85.937325 96.34635 7.6286 56.97869805294927 102.19139049280176 36.145192033990675 108.064;77.4407;1.63089;56.2386 83.8836;58.7732;0.663137;38.2681 143.428;89.8047;7.6286;102.888 1 3 1 25106 RGN_9699 77.4407 77.4407 58.7732 58.7732 89.8047 89.8047 77.4407 58.7732 89.8047 3 246273;25675;25423 TRIB3_10079;HMGCR_8810;CTSC_32456 55.31116333333333 56.2386 53.222615776998715 40.938279 38.2681 41.67443769749777 84.6482 102.888 69.71288968418969 108.064;1.63089;56.2386 83.8836;0.663137;38.2681 143.428;7.6286;102.888 0 Exp 2,1(0.25);Exp 4,1(0.25);Poly 2,2(0.5) 1.7630508165753576 7.072434067726135 1.5736411809921265 1.9017701148986816 0.15263831843614534 1.7985113859176636 16.89778263283298 104.78931236716701 10.924399738311962 79.86961876168805 30.098200908109725 141.7764490918903 DOWN 0.25 0.75 0.0 GO:0070777 8 D-aspartate transport 3 3 1 1 1 1 1 1 161 2 2383 0.98844 0.179 0.179 33.33 29482 slc1a2 SLC1A2_33059 13.3235 13.3235 13.3235 13.3235 9.10952 9.10952 9.10952 9.10952 24.6773 24.6773 24.6773 24.6773 0.0 13.3235 0.0 13.3235 13.3235 9.10952 24.6773 0 1 0 1 29482 SLC1A2_33059 13.3235 13.3235 9.10952 9.10952 24.6773 24.6773 13.3235 9.10952 24.6773 0 Poly 2,1(1) 1.620316982269287 1.620316982269287 1.620316982269287 1.620316982269287 0.0 1.620316982269287 13.3235 13.3235 9.10952 9.10952 24.6773 24.6773 DOWN 0.0 1.0 0.0 GO:0022607 5 cellular component assembly 355 395 17 16 12 13 9 9 153 386 1999 5.2604E-5 0.99998 1.1132E-4 2.28 29482;297784;298699;307582;29328;25661;361969;25373;312382 slc1a2;rrs1;ppan;lama3;gpx4;fn1;fga;ahsg;abcg2 SLC1A2_33059;RRS1_9755;PPAN_9534;LAMA3_8980;GPX4_32827;FN1_8655;FGA_8632;AHSG_8003;ABCG2_32656 31.729841111111106 28.5803 2.46923 24.37613996036209 34.68406013012828 23.90320859637401 21.698844555555556 22.529 0.871501 16.477046034181665 23.019528634278775 15.450561435907883 53.28263333333334 38.8511 10.4175 41.4282725971045 58.14911415030093 41.51070652430881 13.3235;60.39;57.6889;2.46923;45.9204;59.5777;28.5803;12.402;5.21654 9.10952;43.109;41.3659;0.871501;34.2198;31.0499;22.529;10.3013;2.73368 24.6773;104.942;98.1741;10.4175;70.4292;105.243;38.8511;15.4235;11.386 4 5 4 297784;298699;29328;312382 RRS1_9755;PPAN_9534;GPX4_32827;ABCG2_32656 42.303960000000004 51.804649999999995 25.510498376258088 30.357095 37.79285 18.812924766733293 71.23282499999999 84.30165 42.60058314752472 60.39;57.6889;45.9204;5.21654 43.109;41.3659;34.2198;2.73368 104.942;98.1741;70.4292;11.386 5 29482;307582;25661;361969;25373 SLC1A2_33059;LAMA3_8980;FN1_8655;FGA_8632;AHSG_8003 23.270546000000003 13.3235 22.339240602202214 14.7722442 10.3013 11.941689451258904 38.92247999999999 24.6773 38.620194093401444 13.3235;2.46923;59.5777;28.5803;12.402 9.10952;0.871501;31.0499;22.529;10.3013 24.6773;10.4175;105.243;38.8511;15.4235 0 Exp 2,4(0.45);Exp 4,2(0.23);Linear,1(0.12);Poly 2,1(0.12);Power,1(0.12) 1.8414264352948155 17.173747420310974 1.5074360370635986 3.431420087814331 0.6174293468442908 1.6902168989181519 15.804096337007886 47.65558588521434 10.933841146556867 32.46384796455425 26.216161903225053 80.3491047634416 CONFLICT 0.4444444444444444 0.5555555555555556 0.0 GO:0106120 9 positive regulation of sterol biosynthetic process 6 6 2 2 2 2 2 2 160 4 2381 0.99562 0.050905 0.050905 33.33 29441;25428 por;cyp7a1 POR_9531;CYP7A1_8430 9.08134 9.08134 5.72128 4.7518424223873375 11.45117438868866 3.368646070393463 4.7375415 4.7375415 0.985273 5.306509002365351 7.383998684363736 3.7618567935055225 50.799 50.799 22.3625 40.21528396642253 70.85512863875796 28.50916471156574 0.0 5.72128 0.0 5.72128 12.4414;5.72128 8.48981;0.985273 79.2355;22.3625 0 2 0 2 29441;25428 POR_9531;CYP7A1_8430 9.08134 9.08134 4.7518424223873375 4.7375415 4.7375415 5.306509002365351 50.799 50.799 40.21528396642253 12.4414;5.72128 8.48981;0.985273 79.2355;22.3625 0 Hill,1(0.5);Poly 2,1(0.5) 3.0063672693236208 6.542257070541382 1.9819281101226807 4.560328960418701 1.8232047258614763 3.271128535270691 2.495622400000001 15.6670576 -2.616904759999999 12.09198776 -4.936540000000001 106.53453999999999 DOWN 0.0 1.0 0.0 GO:0045646 5 regulation of erythrocyte differentiation 19 21 3 3 2 2 2 2 160 19 2366 0.85485 0.39001 0.39001 9.52 79426;294515 zfp36;foxo3 ZFP36_10204;FOXO3_8662 6.773667 6.773667 0.348134 9.08707591407588 5.9230427987204735 9.007098623006916 2.899251 2.899251 0.118102 3.93313863478037 2.531077239665355 3.8985222437231375 16.958859999999998 16.958859999999998 1.15962 22.343499483187497 14.867326751968504 22.1468495840821 0.5 6.773667 0.348134;13.1992 0.118102;5.6804 1.15962;32.7581 0 2 0 2 79426;294515 ZFP36_10204;FOXO3_8662 6.773667 6.773667 9.08707591407588 2.899251 2.899251 3.93313863478037 16.958859999999998 16.958859999999998 22.343499483187497 0.348134;13.1992 0.118102;5.6804 1.15962;32.7581 0 Exp 4,1(0.5);Hill,1(0.5) 1.963098690322297 3.9265178442001343 1.9381765127182007 1.9883413314819336 0.0354718835248297 1.9632589221000671 -5.820377679999998 19.36771168 -2.551801039999999 8.350303039999998 -14.0076504 47.92537039999999 DOWN 0.0 1.0 0.0 GO:0006766 4 vitamin metabolic process 19 23 4 4 2 4 2 2 160 21 2364 0.82335 0.43545 0.65454 8.7 25106;24384 rgn;gc RGN_9699;GC_32893 59.89835000000001 59.89835000000001 42.356 24.808629285895666 56.249370237551396 24.26598401943512 42.5727 42.5727 26.3722 22.910966817225344 39.20283811481651 22.409829589927153 84.2815 84.2815 78.7583 7.810984347699199 83.13262057255976 7.640132760784367 0.5 59.89835000000001 77.4407;42.356 58.7732;26.3722 89.8047;78.7583 1 1 1 25106 RGN_9699 77.4407 77.4407 58.7732 58.7732 89.8047 89.8047 77.4407 58.7732 89.8047 1 24384 GC_32893 42.356 42.356 26.3722 26.3722 78.7583 78.7583 42.356 26.3722 78.7583 0 Exp 3,1(0.5);Poly 2,1(0.5) 1.6218650784330328 3.249316692352295 1.5294301509857178 1.7198865413665771 0.134673005158618 1.6246583461761475 25.515344000000006 94.28135600000002 10.819719999999993 74.32568 73.456028 95.10697199999998 CONFLICT 0.5 0.5 0.0 GO:0044271 5 cellular nitrogen compound biosynthetic process 201 229 28 28 20 24 17 17 145 212 2173 0.80066 0.28345 0.47771 7.42 298490;303612;24651;81819;294103;100359982;24516;364070;24443;294515;314322;24890;24330;497840;25698;25028;24158 ppcs;polg2;pklr;pax8;papss2;mpc2;jun;iars2;hdc;foxo3;fos;esr1;egr1;cps1;ass1;ampd1;acadm PPCS_9540;POLG2_9521;PKLR_9489;PAX8_9432;PAPSS2_33237;MPC2_33219;JUN_8938;IARS2_8858;HDC_8788;FOXO3_8662;FOS_8657;ESR1_33192;EGR1_8533;CPS1_32421;ASS1_33159;AMPD1_32743;ACADM_7957 28.228195117647132 24.5745 1.28141E-12 19.17294061390788 32.054129781616645 21.098537517459135 21.254072294117723 19.8021 1.28141E-12 14.781433502534426 24.45035983425362 16.547223575415902 44.01156941176478 32.9443 1.28142E-12 32.29385032282306 49.15104811230398 33.79858648482653 10.5 29.39315 20.3353;63.7758;23.0963;56.8931;34.4443;46.8463;16.4324;24.7304;24.5745;13.1992;1.28141E-12;23.3972;0.750017;31.9826;26.8037;60.9045;11.7137 16.7643;40.9553;17.4625;45.1162;25.719;35.8494;10.5224;19.8021;21.0619;5.6804;1.28141E-12;18.3088;0.186019;24.4836;20.9825;50.0633;8.36151 25.6711;132.567;32.9443;81.5688;51.1014;69.127;39.929;32.7087;29.28;32.7581;1.28142E-12;31.9156;4.70178;45.5891;36.7081;82.6625;18.9642 7 10 7 298490;81819;100359982;364070;24443;25028;24158 PPCS_9540;PAX8_9432;MPC2_33219;IARS2_8858;HDC_8788;AMPD1_32743;ACADM_7957 35.14254285714286 24.7304 19.416507025712015 28.14553 21.0619 15.644340706326794 48.5689 32.7087 27.983201957483935 20.3353;56.8931;46.8463;24.7304;24.5745;60.9045;11.7137 16.7643;45.1162;35.8494;19.8021;21.0619;50.0633;8.36151 25.6711;81.5688;69.127;32.7087;29.28;82.6625;18.9642 10 303612;24651;294103;24516;294515;314322;24890;24330;497840;25698 POLG2_9521;PKLR_9489;PAPSS2_33237;JUN_8938;FOXO3_8662;FOS_8657;ESR1_33192;EGR1_8533;CPS1_32421;ASS1_33159 23.38815170000013 23.24675 18.41106045164789 16.43005190000013 17.88565 12.746341490846099 40.82143800000013 34.8262 36.118281811493034 63.7758;23.0963;34.4443;16.4324;13.1992;1.28141E-12;23.3972;0.750017;31.9826;26.8037 40.9553;17.4625;25.719;10.5224;5.6804;1.28141E-12;18.3088;0.186019;24.4836;20.9825 132.567;32.9443;51.1014;39.929;32.7581;1.28142E-12;31.9156;4.70178;45.5891;36.7081 0 Exp 2,11(0.65);Exp 4,1(0.06);Hill,2(0.12);Linear,1(0.06);Poly 2,2(0.12) 2.2891630193231807 50.860639572143555 1.5504547357559204 17.513065338134766 3.7944654632114108 1.8966681957244873 19.113957691913004 37.34243254338128 14.227424835716167 28.28071975251928 28.660047432928465 59.3630913906011 CONFLICT 0.4117647058823529 0.5882352941176471 0.0 GO:0046683 5 response to organophosphorus 70 72 19 19 14 18 13 13 149 59 2326 0.99988 4.52E-4 4.52E-4 18.06 24825;24651;25513;24516;81678;63868;314322;24330;25146;497840;81718;25698;65054 tf;pklr;pik3r1;jun;itpr2;hspd1;fos;egr1;cyp17a1;cps1;cdo1;ass1;aqp9 TF_10003;PKLR_9489;PIK3R1_32562;JUN_8938;ITPR2_8931;HSPD1_8849;FOS_8657;EGR1_8533;CYP17A1_32365;CPS1_32421;CDO1_8275;ASS1_33159;AQP9_32709 25.954455153846254 26.8037 1.28141E-12 15.114170876755239 27.090759093455667 14.473543684520216 18.325939923077023 20.9825 1.28141E-12 10.40178373755111 19.046404406723493 9.654852263769953 42.98754461538472 39.929 1.28142E-12 27.444636328710942 44.19483589773139 27.206778472902506 2.5 17.5824 6.5 27.26765 45.1539;23.0963;18.7324;16.4324;31.8111;42.2579;1.28141E-12;0.750017;49.6922;31.9826;22.9638;26.8037;27.7316 28.132;17.4625;11.6701;10.5224;24.7342;23.9469;1.28141E-12;0.186019;35.6654;24.4836;18.5144;20.9825;21.9372 61.5341;32.9443;41.5978;39.929;44.3296;102.383;1.28142E-12;4.70178;81.6409;45.5891;30.0179;36.7081;37.4625 3 10 3 24825;63868;25146 TF_10003;HSPD1_8849;CYP17A1_32365 45.70133333333333 45.1539 3.7472612083138155 29.248100000000004 28.132 5.938440028323919 81.85266666666666 81.6409 20.42527335541275 45.1539;42.2579;49.6922 28.132;23.9469;35.6654 61.5341;102.383;81.6409 10 24651;25513;24516;81678;314322;24330;497840;81718;25698;65054 PKLR_9489;PIK3R1_32562;JUN_8938;ITPR2_8931;FOS_8657;EGR1_8533;CPS1_32421;CDO1_8275;ASS1_33159;AQP9_32709 20.030391700000127 23.03005 11.51043551071012 15.049291900000128 17.98845 9.205011643569598 31.328008000000136 37.085300000000004 16.031815930474956 23.0963;18.7324;16.4324;31.8111;1.28141E-12;0.750017;31.9826;22.9638;26.8037;27.7316 17.4625;11.6701;10.5224;24.7342;1.28141E-12;0.186019;24.4836;18.5144;20.9825;21.9372 32.9443;41.5978;39.929;44.3296;1.28142E-12;4.70178;45.5891;30.0179;36.7081;37.4625 0 Exp 2,3(0.24);Exp 3,1(0.08);Hill,2(0.16);Linear,4(0.31);Poly 2,3(0.24) 2.0567751504263883 27.661032676696777 1.6674995422363281 4.21828556060791 0.6830703905543228 1.8966681957244873 17.73829827375083 34.17061203394168 12.671465872371263 23.98041397378278 28.06847036165602 57.90661886911341 DOWN 0.23076923076923078 0.7692307692307693 0.0 GO:0010638 7 positive regulation of organelle organization 145 155 5 5 3 5 3 3 159 152 2233 0.008197 0.99798 0.016164 1.94 83516;290556;246142 ppargc1a;gnl3;bmf PPARGC1A_33189;GNL3_8735;BMF_8152 74.97393333333333 87.6357 42.4094 28.43316098613261 76.54824717561006 30.04744458156695 51.281000000000006 54.41 26.2988 23.573961356547585 55.881625373409555 26.611247586763117 143.51383333333334 109.848 81.7305 83.84841092461637 109.69645073452578 47.12372673791146 42.4094;87.6357;94.8767 26.2988;54.41;73.1342 81.7305;238.963;109.848 2 1 2 290556;246142 GNL3_8735;BMF_8152 91.2562 91.2562 5.120160202571743 63.7721 63.7721 13.240008792293176 174.4055 174.4055 91.29809205290108 87.6357;94.8767 54.41;73.1342 238.963;109.848 1 83516 PPARGC1A_33189 42.4094 42.4094 26.2988 26.2988 81.7305 81.7305 42.4094 26.2988 81.7305 0 Exp 2,2(0.67);Poly 2,1(0.34) 1.6788385931859557 5.04132878780365 1.582527995109558 1.7576230764389038 0.08937013158762395 1.701177716255188 42.7987827607923 107.14908390587436 24.604551447265546 77.95744855273445 48.63042420117202 238.3972424654946 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0061045 7 negative regulation of wound healing 33 35 6 6 6 6 6 6 156 29 2356 0.99454 0.020971 0.020971 17.14 85253;288001;25675;361969;113936;114851 plg;kng1;hmgcr;fga;cpb2;cdkn1a PLG_9501;KNG1L1_34113;HMGCR_8810;FGA_8632;CPB2_8369;CDKN1A_8271 26.240610000000004 25.098550000000003 1.63089 24.489583580201604 31.699017427951457 27.822882059692073 18.6405645 19.9877 0.663137 16.53044471628823 21.676359990574355 18.676351572800325 47.17836666666667 33.47545 7.6286 51.95170486721939 60.934101207025165 59.93411416899603 0.5 3.94028 2.5 25.098550000000003 70.7857;24.3655;1.63089;28.5803;25.8316;6.24967 46.2356;19.538;0.663137;22.529;20.4374;2.44025 150.579;32.1467;7.6286;38.8511;34.8042;19.0606 0 6 0 6 85253;288001;25675;361969;113936;114851 PLG_9501;KNG1L1_34113;HMGCR_8810;FGA_8632;CPB2_8369;CDKN1A_8271 26.240610000000004 25.098550000000003 24.489583580201604 18.6405645 19.9877 16.53044471628823 47.17836666666667 33.47545 51.95170486721939 70.7857;24.3655;1.63089;28.5803;25.8316;6.24967 46.2356;19.538;0.663137;22.529;20.4374;2.44025 150.579;32.1467;7.6286;38.8511;34.8042;19.0606 0 Exp 2,1(0.17);Exp 4,2(0.34);Linear,3(0.5) 1.7137571812253052 10.434736728668213 1.522104263305664 2.3804118633270264 0.3465078210551421 1.5524907112121582 6.644861963653181 45.83635803634682 5.41345393977714 31.86767506022285 5.608345057164755 88.74838827616858 DOWN 0.0 1.0 0.0 GO:0071496 4 cellular response to external stimulus 143 149 17 17 15 12 10 10 152 139 2246 0.65268 0.47888 0.86205 6.71 29482;24539;24516;24957;25112;294515;314322;24330;114851;246142 slc1a2;lpl;jun;glul;gadd45a;foxo3;fos;egr1;cdkn1a;bmf SLC1A2_33059;LPL_32544;JUN_8938;GLUL_32832;GADD45A_8678;FOXO3_8662;FOS_8657;EGR1_8533;CDKN1A_8271;BMF_8152 34.84214870000012 14.87795 1.28141E-12 39.89190945436874 46.79256536840619 43.72964475373006 26.148778900000128 9.81596 1.28141E-12 32.801092301849984 35.77682260292677 36.11620505090628 53.72670800000013 34.0942 1.28142E-12 53.33409356785834 68.99809836430612 58.07511884623116 6.5 50.335499999999996 13.3235;74.2041;16.4324;26.4669;102.919;13.1992;1.28141E-12;0.750017;6.24967;94.8767 9.10952;49.8682;10.5224;21.0456;89.5012;5.6804;1.28141E-12;0.186019;2.44025;73.1342 24.6773;155.425;39.929;35.4303;115.437;32.7581;1.28142E-12;4.70178;19.0606;109.848 2 8 2 24539;246142 LPL_32544;BMF_8152 84.5404 84.5404 14.617735644756898 61.501200000000004 61.501200000000004 16.45154637108624 132.6365 132.6365 32.227805766139305 74.2041;94.8767 49.8682;73.1342 155.425;109.848 8 29482;24516;24957;25112;294515;314322;24330;114851 SLC1A2_33059;JUN_8938;GLUL_32832;GADD45A_8678;FOXO3_8662;FOS_8657;EGR1_8533;CDKN1A_8271 22.41758587500016 13.26135 33.66603058651498 17.31067362500016 7.394959999999999 29.971575423750725 33.99926000000016 28.7177 35.84731546461526 13.3235;16.4324;26.4669;102.919;13.1992;1.28141E-12;0.750017;6.24967 9.10952;10.5224;21.0456;89.5012;5.6804;1.28141E-12;0.186019;2.44025 24.6773;39.929;35.4303;115.437;32.7581;1.28142E-12;4.70178;19.0606 0 Exp 2,1(0.1);Exp 4,2(0.2);Hill,2(0.2);Linear,1(0.1);Poly 2,4(0.4) 1.9499694745180631 20.48102855682373 1.522104263305664 4.21828556060791 0.8048543157429455 1.7989229559898376 10.116887058554166 59.56741034144609 5.818451262608928 46.47910653739132 20.66989432746631 86.78352167253395 DOWN 0.2 0.8 0.0 GO:0051249 6 regulation of lymphocyte activation 121 128 5 5 3 5 3 3 159 125 2260 0.031126 0.99081 0.060994 2.34 63868;246186;114851 hspd1;fgl1;cdkn1a HSPD1_8849;FGL1_8640;CDKN1A_8271 21.327756666666666 15.4757 6.24967 18.70382534017128 18.705757550173562 17.11540106691505 12.200316666666666 10.2138 2.44025 10.890072768619746 10.778177624386545 10.05684161689821 50.618066666666664 30.4106 19.0606 45.18751893225975 43.91501528947053 41.151228703698244 42.2579;15.4757;6.24967 23.9469;10.2138;2.44025 102.383;30.4106;19.0606 1 2 1 63868 HSPD1_8849 42.2579 42.2579 23.9469 23.9469 102.383 102.383 42.2579 23.9469 102.383 2 246186;114851 FGL1_8640;CDKN1A_8271 10.862684999999999 10.862684999999999 6.523788376430524 6.327025000000001 6.327025000000001 5.4967299188926875 24.735599999999998 24.735599999999998 8.025661966467322 15.4757;6.24967 10.2138;2.44025 30.4106;19.0606 0 Exp 3,1(0.34);Exp 4,1(0.34);Poly 2,1(0.34) 1.7302690508731653 5.285276651382446 1.511321783065796 2.2518506050109863 0.4244661198187585 1.522104263305664 0.16238582042034722 42.493127512912984 -0.12296076446949122 24.52359409780282 -0.5164247236542252 101.75255805698755 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0071560 6 cellular response to transforming growth factor beta stimulus 33 37 3 3 3 3 3 3 159 34 2351 0.79406 0.42166 0.508 8.11 83516;25591;25661 ppargc1a;parp1;fn1 PPARGC1A_33189;PARP1_9425;FN1_8655 42.987066666666664 42.4094 26.9741 16.309474464964644 44.61792396480331 17.357401567231385 26.382566666666666 26.2988 21.799 4.626018843815198 26.833855318322982 4.919898923500125 74.0844 81.7305 35.2797 35.60285059696766 76.31463249223603 37.290053814298076 0.5 34.69175 42.4094;26.9741;59.5777 26.2988;21.799;31.0499 81.7305;35.2797;105.243 1 2 1 25591 PARP1_9425 26.9741 26.9741 21.799 21.799 35.2797 35.2797 26.9741 21.799 35.2797 2 83516;25661 PPARGC1A_33189;FN1_8655 50.99355 50.99355 12.139821351444999 28.67435 28.67435 3.3595350280954177 93.48675 93.48675 16.625848192648668 42.4094;59.5777 26.2988;31.0499 81.7305;105.243 0 Exp 2,2(0.67);Power,1(0.34) 1.7817194611226557 5.345526337623596 1.7576230764389038 1.8086696863174438 0.025623084252686647 1.7792335748672485 24.531158900196896 61.44297443313643 21.14773354615081 31.61739978718252 33.79598186288848 114.37281813711152 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0043252 7 sodium-independent organic anion transport 7 7 2 2 1 2 1 1 161 6 2379 0.93166 0.36908 0.36908 14.29 170698 slco1a2 SLCO1A2_9886 104.197 104.197 104.197 104.197 80.3101 80.3101 80.3101 80.3101 128.412 128.412 128.412 128.412 0.0 104.197 0.0 104.197 104.197 80.3101 128.412 0 1 0 1 170698 SLCO1A2_9886 104.197 104.197 80.3101 80.3101 128.412 128.412 104.197 80.3101 128.412 0 Poly 2,1(1) 1.5806894302368164 1.5806894302368164 1.5806894302368164 1.5806894302368164 0.0 1.5806894302368164 104.197 104.197 80.3101 80.3101 128.412 128.412 DOWN 0.0 1.0 0.0 GO:0003197 6 endocardial cushion development 4 4 1 1 1 1 1 1 161 3 2382 0.97784 0.23128 0.23128 25.0 29496 erbb3 ERBB3_8571 60.9984 60.9984 60.9984 60.9984 41.6036 41.6036 41.6036 41.6036 113.972 113.972 113.972 113.972 0.0 60.9984 0.0 60.9984 60.9984 41.6036 113.972 1 0 1 29496 ERBB3_8571 60.9984 60.9984 41.6036 41.6036 113.972 113.972 60.9984 41.6036 113.972 0 0 Linear,1(1) 1.6013026237487793 1.6013026237487793 1.6013026237487793 1.6013026237487793 0.0 1.6013026237487793 60.9984 60.9984 41.6036 41.6036 113.972 113.972 UP 1.0 0.0 0.0 GO:0072574 6 hepatocyte proliferation 5 5 1 1 1 1 1 1 161 4 2381 0.9646 0.28025 0.28025 20.0 246186 fgl1 FGL1_8640 15.4757 15.4757 15.4757 15.4757 10.2138 10.2138 10.2138 10.2138 30.4106 30.4106 30.4106 30.4106 0.0 15.4757 0.0 15.4757 15.4757 10.2138 30.4106 0 1 0 1 246186 FGL1_8640 15.4757 15.4757 10.2138 10.2138 30.4106 30.4106 15.4757 10.2138 30.4106 0 Poly 2,1(1) 1.511321783065796 1.511321783065796 1.511321783065796 1.511321783065796 0.0 1.511321783065796 15.4757 15.4757 10.2138 10.2138 30.4106 30.4106 DOWN 0.0 1.0 0.0 GO:0034764 6 positive regulation of transmembrane transport 60 63 7 7 6 6 5 5 157 58 2327 0.7914 0.37237 0.59626 7.94 362895;29482;25106;81869;29496 stac3;slc1a2;rgn;gstm7;erbb3 STAC3_9953;SLC1A2_33059;RGN_9699;GSTM7_8761;ERBB3_8571 51.46342 60.9984 13.3235 24.712090645815465 51.778683565140184 24.46859261528057 36.718584 41.6036 9.10952 18.279732170255677 36.85247666789968 18.06115308460107 82.91461999999999 89.8047 24.6773 39.46344236590368 84.1234469371902 39.534145630696166 2.5 62.118849999999995 63.2393;13.3235;77.4407;42.3152;60.9984 42.7031;9.10952;58.7732;31.4035;41.6036 121.52;24.6773;89.8047;64.5991;113.972 3 2 3 25106;81869;29496 RGN_9699;GSTM7_8761;ERBB3_8571 60.25143333333333 60.9984 17.57465951201709 43.92676666666667 41.6036 13.831953840413616 89.45859999999999 89.8047 24.68826953251284 77.4407;42.3152;60.9984 58.7732;31.4035;41.6036 89.8047;64.5991;113.972 2 362895;29482 STAC3_9953;SLC1A2_33059 38.2814 38.2814 35.295800668351475 25.906309999999998 25.906309999999998 23.75424822233278 73.09864999999999 73.09864999999999 68.47812987841448 63.2393;13.3235 42.7031;9.10952 121.52;24.6773 0 Linear,3(0.6);Poly 2,2(0.4) 1.8637287843790702 9.570809721946716 1.6013026237487793 2.879150867462158 0.5431554565831411 1.7198865413665771 29.802317496329415 73.12452250367056 20.695692292672877 52.741475707327126 48.32338761552816 117.50585238447184 UP 0.6 0.4 0.0 GO:0045598 6 regulation of fat cell differentiation 37 42 5 5 4 5 4 4 158 38 2347 0.87537 0.27636 0.33819 9.52 79426;246273;360268;24539 zfp36;trib3;sult1e1;lpl ZFP36_10204;TRIB3_10079;SULT1E1_32446;LPL_32544 58.2002085 62.19435 0.348134 45.29030341209203 67.065761784752 35.667721422697326 42.5927005 43.18455 0.118102 34.63655499402139 47.98787488273118 27.429521626299888 95.247855 112.2034 1.15962 70.70788982044438 118.11100730863441 59.75440258275964 1.5 62.19435 0.348134;108.064;50.1846;74.2041 0.118102;83.8836;36.5009;49.8682 1.15962;143.428;80.9788;155.425 2 2 2 360268;24539 SULT1E1_32446;LPL_32544 62.19435 62.19435 16.984351330710293 43.18455 43.18455 9.452108476154955 118.20190000000001 118.20190000000001 52.641412853569946 50.1846;74.2041 36.5009;49.8682 80.9788;155.425 2 79426;246273 ZFP36_10204;TRIB3_10079 54.206067 54.206067 76.16661928998148 42.000851 42.000851 59.231151665268186 72.29381 72.29381 100.5989362464246 0.348134;108.064 0.118102;83.8836 1.15962;143.428 0 Exp 2,2(0.5);Hill,1(0.25);Poly 2,1(0.25) 1.7725933642165757 7.114875435829163 1.559399127960205 1.9381765127182007 0.16802814990297169 1.8086498975753784 13.815711156149817 102.58470584385019 8.648876605859044 76.53652439414097 25.954122975964538 164.5415870240355 CONFLICT 0.5 0.5 0.0 GO:0070301 6 cellular response to hydrogen peroxide 41 45 4 4 4 4 4 4 158 41 2344 0.84571 0.32039 0.52852 8.89 24314;58954;24471;24360 nqo1;klf6;hspb1;fabp1 NQO1_33055;KLF6_8969;HSPB1_8847;FABP1_33091 57.29325 60.56215 18.9476 36.19766383718706 56.80091462216699 35.55808941564097 39.79835 43.40005 11.6941 24.66879475349374 39.478955843541044 23.619652544498866 98.9322 76.53185 45.5481 71.28982320953439 80.34828150186401 48.15672677909912 1.5 60.56215 87.2765;18.9476;89.1011;33.8478 60.6992;11.6941;60.3265;26.4736 197.117;45.5481;106.138;46.9257 2 2 2 24314;24360 NQO1_33055;FABP1_33091 60.56215 60.56215 37.77979607998167 43.5864 43.5864 24.20115385017831 122.02135 122.02135 106.20128670522311 87.2765;33.8478 60.6992;26.4736 197.117;46.9257 2 58954;24471 KLF6_8969;HSPB1_8847 54.02435 54.02435 49.606015573970474 36.0103 36.0103 34.388299825376656 75.84305 75.84305 42.8435291614148 18.9476;89.1011 11.6941;60.3265 45.5481;106.138 0 Exp 2,2(0.5);Poly 2,2(0.5) 1.676503484398528 6.72343385219574 1.5740432739257812 1.8753424882888794 0.14182977910825934 1.6370240449905396 21.819539439556678 92.76696056044332 15.622931141576139 63.97376885842386 29.0681732546563 168.7962267453437 CONFLICT 0.5 0.5 0.0 GO:2000377 6 regulation of reactive oxygen species metabolic process 96 100 11 11 10 11 10 10 152 90 2295 0.95034 0.099563 0.13962 10.0 293615;25106;63868;24464;25112;294515;24890;114851;29184;25698 sirt3;rgn;hspd1;hp;gadd45a;foxo3;esr1;cdkn1a;cd36;ass1 SIRT3_9828;RGN_9699;HSPD1_8849;HP_8823;GADD45A_8678;FOXO3_8662;ESR1_33192;CDKN1A_8271;CD36_8243;ASS1_33159 40.770565 34.5308 2.38018 32.94726646599086 46.46067703374748 34.820499247339356 29.934894000000003 22.4647 0.56209 27.95265975307029 34.77040586980024 30.141460592068235 64.249337 52.9251 8.82917 44.56472412611823 72.10347226402541 46.02635725177618 4.0 26.8037 9.0 102.919 2.38018;77.4407;42.2579;64.9285;102.919;13.1992;23.3972;6.24967;48.1296;26.8037 0.56209;58.7732;23.9469;41.6103;89.5012;5.6804;18.3088;2.44025;37.5433;20.9825 8.82917;89.8047;102.383;136.455;115.437;32.7581;31.9156;19.0606;69.1421;36.7081 4 6 4 293615;25106;63868;29184 SIRT3_9828;RGN_9699;HSPD1_8849;CD36_8243 42.55209500000001 45.19375 30.887929823456382 30.2063725 30.7451 24.412146017048396 67.5397425 79.4734 41.46998833905339 2.38018;77.4407;42.2579;48.1296 0.56209;58.7732;23.9469;37.5433 8.82917;89.8047;102.383;69.1421 6 24464;25112;294515;24890;114851;25698 HP_8823;GADD45A_8678;FOXO3_8662;ESR1_33192;CDKN1A_8271;ASS1_33159 39.582878333333326 25.100450000000002 37.11158764488548 29.75390833333334 19.645650000000003 32.3845973536559 62.055733333333336 34.7331 50.284537332490856 64.9285;102.919;13.1992;23.3972;6.24967;26.8037 41.6103;89.5012;5.6804;18.3088;2.44025;20.9825 136.455;115.437;32.7581;31.9156;19.0606;36.7081 0 Exp 2,4(0.4);Exp 3,1(0.1);Exp 4,2(0.2);Hill,1(0.1);Poly 2,2(0.2) 1.890337317072949 19.25946819782257 1.5209722518920898 2.6703107357025146 0.4038135647228071 1.8006581664085388 20.349637677032536 61.19149232296746 12.609655990033303 47.2601320099667 36.627834819024265 91.87083918097574 DOWN 0.4 0.6 0.0 GO:0002684 5 positive regulation of immune system process 239 264 15 14 10 12 8 8 154 256 2129 0.0089303 0.99648 0.01611 3.03 24516;63868;294515;314322;25423;114851;29184;313421 jun;hspd1;foxo3;fos;ctsc;cdkn1a;cd36;c8b JUN_8938;HSPD1_8849;FOXO3_8662;FOS_8657;CTSC_32456;CDKN1A_8271;CD36_8243;C8B_8181 25.48364625000016 18.897100000000002 1.28141E-12 20.733914087510012 30.99561925472755 21.71116507501923 16.95126875000016 13.8656 1.28141E-12 15.088890130796063 21.058303153967444 16.122656492691384 49.25961250000016 36.34355 1.28142E-12 38.26002595844954 58.167461575361585 38.55093715456133 16.4324;42.2579;13.1992;1.28141E-12;56.2386;6.24967;48.1296;21.3618 10.5224;23.9469;5.6804;1.28141E-12;38.2681;2.44025;37.5433;17.2088 39.929;102.383;32.7581;1.28142E-12;102.888;19.0606;69.1421;27.9161 2 6 2 63868;29184 HSPD1_8849;CD36_8243 45.19375 45.19375 4.151918887092963 30.7451 30.7451 9.61410663972478 85.76255 85.76255 23.504865802743858 42.2579;48.1296 23.9469;37.5433 102.383;69.1421 6 24516;294515;314322;25423;114851;313421 JUN_8938;FOXO3_8662;FOS_8657;CTSC_32456;CDKN1A_8271;C8B_8181 18.91361166666688 14.8158 19.77907690992699 12.353325000000211 8.1014 14.09897237176326 37.091966666666885 30.3371 35.045940891844346 16.4324;13.1992;1.28141E-12;56.2386;6.24967;21.3618 10.5224;5.6804;1.28141E-12;38.2681;2.44025;17.2088 39.929;32.7581;1.28142E-12;102.888;19.0606;27.9161 0 Exp 2,3(0.38);Exp 3,1(0.13);Exp 4,2(0.25);Hill,1(0.13);Poly 2,1(0.13) 1.8895646579820593 15.393669843673706 1.5122476816177368 2.6703107357025146 0.40109396190471003 1.937587022781372 11.1157768232189 39.85151567678142 6.495201348576781 27.407336151423532 22.74676717247902 75.7724578275213 DOWN 0.25 0.75 0.0 GO:1901654 5 response to ketone 140 154 26 26 19 21 15 15 147 139 2246 0.96784 0.060638 0.086688 9.74 286954;25513;25591;58954;294515;314322;25661;361969;116636;140942;497840;114851;25698;312382;25303 ugt2b1;pik3r1;parp1;klf6;foxo3;fos;fn1;fga;eif4ebp1;ddit4;cps1;cdkn1a;ass1;abcg2;abcc2 UGT2B10_33303,UGT2B1_33224;PIK3R1_32562;PARP1_9425;KLF6_8969;FOXO3_8662;FOS_8657;FN1_8655;FGA_8632;EIF4EBP1_8550;DDIT4_8450;CPS1_32421;CDKN1A_8271;ASS1_33159;ABCG2_32656;ABCC2_32541 33.42740400000009 26.9741 1.28141E-12 26.88431853951119 33.70624665794811 24.850934632814006 21.11561866666675 21.799 1.28141E-12 15.667839182236875 21.4095467951361 14.02404779487393 61.539543333333405 41.5978 1.28142E-12 59.8458533690718 56.08279717800377 44.86570584497305 6.5 26.8889 47.47345;18.7324;26.9741;18.9476;13.1992;1.28141E-12;59.5777;28.5803;83.9001;87.5421;31.9826;6.24967;26.8037;5.21654;46.2316 34.82915;11.6701;21.799;11.6941;5.6804;1.28141E-12;31.0499;22.529;42.4185;53.2453;24.4836;2.44025;20.9825;2.73368;31.1788 76.47475;41.5978;35.2797;45.5481;32.7581;1.28142E-12;105.243;38.8511;107.32;245.492;45.5891;19.0606;36.7081;11.386;81.7848 5 11 4 286954;25591;116636;312382 UGT2B10_33303,UGT2B1_33224;PARP1_9425;EIF4EBP1_8550;ABCG2_32656 40.8910475 37.223775 33.463704381040834 25.445082499999998 28.314075 17.371042432620207 57.615112499999995 55.877224999999996 42.67029904629948 47.47345;26.9741;83.9001;5.21654 34.82915;21.799;42.4185;2.73368 76.47475;35.2797;107.32;11.386 11 25513;58954;294515;314322;25661;361969;140942;497840;114851;25698;25303 PIK3R1_32562;KLF6_8969;FOXO3_8662;FOS_8657;FN1_8655;FGA_8632;DDIT4_8450;CPS1_32421;CDKN1A_8271;ASS1_33159;ABCC2_32541 30.713351818181934 26.8037 25.407524210531193 19.541268181818296 20.9825 15.586006021753342 62.966609090909216 41.5978 66.77956030224286 18.7324;18.9476;13.1992;1.28141E-12;59.5777;28.5803;87.5421;31.9826;6.24967;26.8037;46.2316 11.6701;11.6941;5.6804;1.28141E-12;31.0499;22.529;53.2453;24.4836;2.44025;20.9825;31.1788 41.5978;45.5481;32.7581;1.28142E-12;105.243;38.8511;245.492;45.5891;19.0606;36.7081;81.7848 0 Exp 2,6(0.38);Exp 3,1(0.07);Exp 4,3(0.19);Hill,1(0.07);Linear,2(0.13);Poly 2,2(0.13);Power,1(0.07) 1.7199819516390764 27.61391818523407 1.5074360370635986 1.9883413314819336 0.14700901320695053 1.723293125629425 19.822061650918897 47.032746349081265 13.186598050749115 29.044639282584388 31.253362857436578 91.82572380923025 DOWN 0.26666666666666666 0.7333333333333333 0.0 GO:0007204 11 positive regulation of cytosolic calcium ion concentration 73 76 8 8 6 7 5 5 157 71 2314 0.64676 0.53706 0.81305 6.58 288001;81678;81869;24890;29184 kng1;itpr2;gstm7;esr1;cd36 KNG1L1_34113;ITPR2_8931;GSTM7_8761;ESR1_33192;CD36_8243 34.00372 31.8111 23.3972 10.941004516359529 38.947931610038296 9.723807970424483 26.305560000000003 24.7342 18.3088 8.131620435866388 30.056174443901245 7.447482174950541 48.42662 44.3296 31.9156 17.64309617462309 56.046909150167025 15.306686554484605 2.5 37.06315 24.3655;31.8111;42.3152;23.3972;48.1296 19.538;24.7342;31.4035;18.3088;37.5433 32.1467;44.3296;64.5991;31.9156;69.1421 2 3 2 81869;29184 GSTM7_8761;CD36_8243 45.2224 45.2224 4.111401668531036 34.4734 34.4734 4.341494215129178 66.8706 66.8706 3.212386106930976 42.3152;48.1296 31.4035;37.5433 64.5991;69.1421 3 288001;81678;24890 KNG1L1_34113;ITPR2_8931;ESR1_33192 26.524600000000003 24.3655 4.603771596202391 20.860333333333333 19.538 3.410698663519439 36.130633333333336 32.1467 7.101453555669651 24.3655;31.8111;23.3972 19.538;24.7342;18.3088 32.1467;44.3296;31.9156 0 Exp 2,2(0.4);Linear,3(0.6) 2.143096511293137 10.90536105632782 1.6674995422363281 2.6703107357025146 0.4455421163668407 2.3804118633270264 24.413506702440838 43.59393329755916 19.177880423765096 33.433239576234904 32.961764347030694 63.891475652969305 DOWN 0.4 0.6 0.0 GO:0051130 6 positive regulation of cellular component organization 262 280 13 13 11 13 11 11 151 269 2116 0.044625 0.97698 0.090387 3.93 24825;83516;25513;24471;290556;29455;25661;24890;113936;29184;246142 tf;ppargc1a;pik3r1;hspb1;gnl3;gdf15;fn1;esr1;cpb2;cd36;bmf TF_10003;PPARGC1A_33189;PIK3R1_32562;HSPB1_8847;GNL3_8735;GDF15_33113;FN1_8655;ESR1_33192;CPB2_8369;CD36_8243;BMF_8152 58.18130000000001 48.1296 18.7324 31.161222595045903 65.42149171883528 28.121076004456828 40.605427272727276 31.0499 11.6701 24.169528791686893 45.98921295226171 24.028512636373357 91.50620909090908 81.7305 31.9156 58.651260222802634 92.02932803139748 35.14322260416003 45.1539;42.4094;18.7324;89.1011;87.6357;105.149;59.5777;23.3972;25.8316;48.1296;94.8767 28.132;26.2988;11.6701;60.3265;54.41;85.3487;31.0499;18.3088;20.4374;37.5433;73.1342 61.5341;81.7305;41.5978;106.138;238.963;125.652;105.243;31.9156;34.8042;69.1421;109.848 4 7 4 24825;290556;29184;246142 TF_10003;GNL3_8735;CD36_8243;BMF_8152 68.94897499999999 67.88265 25.95568392823624 48.304875 45.97665 19.803403019578045 119.87180000000001 89.49504999999999 82.17862696033963 45.1539;87.6357;48.1296;94.8767 28.132;54.41;37.5433;73.1342 61.5341;238.963;69.1421;109.848 7 83516;25513;24471;29455;25661;24890;113936 PPARGC1A_33189;PIK3R1_32562;HSPB1_8847;GDF15_33113;FN1_8655;ESR1_33192;CPB2_8369 52.02834285714285 42.4094 34.05960921873381 36.20574285714286 26.2988 26.747306296576053 75.29730000000002 81.7305 38.906286857139136 42.4094;18.7324;89.1011;105.149;59.5777;23.3972;25.8316 26.2988;11.6701;60.3265;85.3487;31.0499;18.3088;20.4374 81.7305;41.5978;106.138;125.652;105.243;31.9156;34.8042 0 Exp 2,5(0.46);Poly 2,5(0.46);Power,1(0.1) 1.8131892485749996 20.25693154335022 1.5606178045272827 2.6703107357025146 0.3666939894593916 1.701177716255188 39.766194238294204 76.5964057617058 26.322148510094003 54.88870603536055 56.84552924223233 126.16688893958583 DOWN 0.36363636363636365 0.6363636363636364 0.0 GO:0097187 5 dentinogenesis 2 2 1 1 1 1 1 1 161 1 2384 0.99598 0.12319 0.12319 50.0 65164 htra1 HTRA1_8856 33.1323 33.1323 33.1323 33.1323 25.6145 25.6145 25.6145 25.614499999999996 46.6629 46.6629 46.6629 46.6629 0.0 33.1323 0.0 33.1323 33.1323 25.6145 46.6629 0 1 0 1 65164 HTRA1_8856 33.1323 33.1323 25.6145 25.6145 46.6629 46.6629 33.1323 25.6145 46.6629 0 Linear,1(1) 1.5603101253509521 1.5603101253509521 1.5603101253509521 1.5603101253509521 0.0 1.5603101253509521 33.1323 33.1323 25.6145 25.6145 46.6629 46.6629 DOWN 0.0 1.0 0.0 GO:0038183 5 bile acid signaling pathway 14 14 6 6 5 5 4 4 158 10 2375 0.99878 0.0095446 0.0095446 28.57 170698;25675;25428;25303 slco1a2;hmgcr;cyp7a1;abcc2 SLCO1A2_9886;HMGCR_8810;CYP7A1_8430;ABCC2_32541 39.445192500000005 25.97644 1.63089 47.63078713445144 42.81574121975101 38.366880660047975 28.284327500000003 16.0820365 0.663137 37.51989479598912 30.047401015666527 30.15684383885093 60.046975 52.07365 7.6286 55.71988087043828 69.01760563715206 46.035592867075444 0.0 1.63089 0.5 3.676085 104.197;1.63089;5.72128;46.2316 80.3101;0.663137;0.985273;31.1788 128.412;7.6286;22.3625;81.7848 0 4 0 4 170698;25675;25428;25303 SLCO1A2_9886;HMGCR_8810;CYP7A1_8430;ABCC2_32541 39.445192500000005 25.97644 47.63078713445144 28.284327500000003 16.0820365 37.51989479598912 60.046975 52.07365 55.71988087043828 104.197;1.63089;5.72128;46.2316 80.3101;0.663137;0.985273;31.1788 128.412;7.6286;22.3625;81.7848 0 Exp 2,1(0.25);Exp 4,1(0.25);Hill,1(0.25);Poly 2,1(0.25) 2.246818820487577 9.90175461769104 1.5806894302368164 4.560328960418701 1.3971969260927812 1.8803681135177612 -7.232978891762421 86.12336389176241 -8.485169400069331 65.05382440006935 5.441491746970492 114.65245825302952 DOWN 0.0 1.0 0.0 GO:0003018 5 vascular process in circulatory system 70 73 11 11 9 9 7 7 155 66 2319 0.91113 0.17879 0.22575 9.59 288001;25675;361969;497840;29184;312382;25303 kng1;hmgcr;fga;cps1;cd36;abcg2;abcc2 KNG1L1_34113;HMGCR_8810;FGA_8632;CPS1_32421;CD36_8243;ABCG2_32656;ABCC2_32541 26.591004285714288 28.5803 1.63089 18.108555092016456 29.47009434697856 17.455761559537645 19.809931 22.529 0.663137 13.730938859256508 22.19983217907381 13.646390333125229 40.932628571428566 38.8511 7.6286 27.537985268698364 44.187646096096096 25.773087808769088 2.5 26.472900000000003 24.3655;1.63089;28.5803;31.9826;48.1296;5.21654;46.2316 19.538;0.663137;22.529;24.4836;37.5433;2.73368;31.1788 32.1467;7.6286;38.8511;45.5891;69.1421;11.386;81.7848 2 5 2 29184;312382 CD36_8243;ABCG2_32656 26.673070000000003 26.673070000000003 30.344115727465187 20.13849 20.13849 24.614118352526866 40.26405 40.26405 40.83972996488837 48.1296;5.21654 37.5433;2.73368 69.1421;11.386 5 288001;25675;361969;497840;25303 KNG1L1_34113;HMGCR_8810;FGA_8632;CPS1_32421;ABCC2_32541 26.558177999999998 28.5803 16.176637385854338 19.678507399999997 22.529 11.45725759749574 41.20006 38.8511 26.837048365515162 24.3655;1.63089;28.5803;31.9826;46.2316 19.538;0.663137;22.529;24.4836;31.1788 32.1467;7.6286;38.8511;45.5891;81.7848 0 Exp 2,3(0.43);Exp 4,2(0.29);Linear,2(0.29) 1.9177545722832938 13.687266230583191 1.5074360370635986 2.6703107357025146 0.4266511005533115 1.8589661121368408 13.175998940381671 40.00600963104691 9.637909143072823 29.981952856927172 20.532203595382477 61.33305354747467 DOWN 0.2857142857142857 0.7142857142857143 0.0 GO:0046626 6 regulation of insulin receptor signaling pathway 27 27 2 2 2 2 2 2 160 25 2360 0.75576 0.5205 0.6885 7.41 25513;25373 pik3r1;ahsg PIK3R1_32562;AHSG_8003 15.5672 15.5672 12.402 4.476268767623311 15.391176825903875 4.46934153588225 10.9857 10.9857 10.3013 0.9678877620881425 10.9476391316974 0.9663899112718778 28.51065 28.51065 15.4235 18.508025022811054 27.78284711775809 18.479383003071323 0.5 15.5672 18.7324;12.402 11.6701;10.3013 41.5978;15.4235 0 2 0 2 25513;25373 PIK3R1_32562;AHSG_8003 15.5672 15.5672 4.476268767623311 10.9857 10.9857 0.9678877620881425 28.51065 28.51065 18.508025022811054 18.7324;12.402 11.6701;10.3013 41.5978;15.4235 0 Exp 2,1(0.5);Poly 2,1(0.5) 2.396404849716079 5.105000138282776 1.6735800504684448 3.431420087814331 1.2429806106484902 2.552500069141388 9.363408000000002 21.770992 9.644276 12.327124 2.8598360000000014 54.161463999999995 DOWN 0.0 1.0 0.0 GO:0051338 5 regulation of transferase activity 261 279 21 21 18 19 16 16 146 263 2122 0.38334 0.71352 0.79454 5.73 79426;246273;24825;25106;303612;25513;24471;25675;29455;299626;25112;29496;24330;116663;114851;25373 zfp36;trib3;tf;rgn;polg2;pik3r1;hspb1;hmgcr;gdf15;gadd45b;gadd45a;erbb3;egr1;dusp6;cdkn1a;ahsg ZFP36_10204;TRIB3_10079;TF_10003;RGN_9699;POLG2_9521;PIK3R1_32562;HSPB1_8847;HMGCR_8810;GDF15_33113;GADD45B_8679;GADD45A_8678;ERBB3_8571;EGR1_8533;DUSP6_8506;CDKN1A_8271;AHSG_8003 53.84221318749999 61.695899999999995 0.348134 41.999847365327476 58.002724482841984 40.78369986598468 37.85648175 40.0214 0.118102 31.885167730367158 42.465353378543895 33.067048463837935 76.30266875000001 97.97135 1.15962 53.14844845528867 80.88437428483762 50.139650848621926 12.5 104.03399999999999 0.348134;108.064;45.1539;77.4407;63.7758;18.7324;89.1011;1.63089;105.149;106.367;102.919;60.9984;0.750017;62.3934;6.24967;12.402 0.118102;83.8836;28.132;58.7732;40.9553;11.6701;60.3265;0.663137;85.3487;52.7132;89.5012;41.6036;0.186019;39.0875;2.44025;10.3013 1.15962;143.428;61.5341;89.8047;132.567;41.5978;106.138;7.6286;125.652;109.434;115.437;113.972;4.70178;133.304;19.0606;15.4235 4 12 4 24825;25106;299626;29496 TF_10003;RGN_9699;GADD45B_8679;ERBB3_8571 72.49000000000001 69.21955 26.15007835080674 45.3055 47.1584 13.476969595573046 93.68619999999999 99.61935 23.86301505915245 45.1539;77.4407;106.367;60.9984 28.132;58.7732;52.7132;41.6036 61.5341;89.8047;109.434;113.972 12 79426;246273;303612;25513;24471;25675;29455;25112;24330;116663;114851;25373 ZFP36_10204;TRIB3_10079;POLG2_9521;PIK3R1_32562;HSPB1_8847;HMGCR_8810;GDF15_33113;GADD45A_8678;EGR1_8533;DUSP6_8506;CDKN1A_8271;AHSG_8003 47.62628425 40.5629 45.28065491486671 35.373475666666664 25.3788 36.19283877859985 70.50815833333333 73.8679 59.58292028640878 0.348134;108.064;63.7758;18.7324;89.1011;1.63089;105.149;102.919;0.750017;62.3934;6.24967;12.402 0.118102;83.8836;40.9553;11.6701;60.3265;0.663137;85.3487;89.5012;0.186019;39.0875;2.44025;10.3013 1.15962;143.428;132.567;41.5978;106.138;7.6286;125.652;115.437;4.70178;133.304;19.0606;15.4235 0 Exp 2,3(0.19);Exp 4,2(0.13);Hill,2(0.13);Linear,1(0.07);Poly 2,7(0.44);Power,1(0.07) 1.8679356076637674 31.34890902042389 1.522104263305664 4.21828556060791 0.7538834431979053 1.6854488253593445 33.262287978489546 74.42213839651046 22.23274956212009 53.48021393787991 50.25992900690854 102.34540849309144 DOWN 0.25 0.75 0.0 GO:0034220 5 ion transmembrane transport 134 136 10 9 8 8 6 6 156 130 2255 0.22433 0.87656 0.46807 4.41 29573;29482;100359982;81678;170945;140668 slc37a4;slc1a2;mpc2;itpr2;chrna2;abcc3 SLC37A4_9871;SLC1A2_33059;MPC2_33219;ITPR2_8931;CHRNA2_32401;ABCC3_7941 36.46771666666667 38.71705 13.3235 12.99376807064319 37.28729624157992 12.395941479962959 27.522886666666665 27.81745 9.10952 11.456442792536734 28.107838804858137 11.319539398702092 51.59536666666667 54.483149999999995 24.6773 16.008261202350077 52.28534869361094 14.911919126871306 39.7166;13.3235;46.8463;31.8111;49.3913;37.7175 22.6911;9.10952;35.8494;24.7342;41.8524;30.9007 60.0334;24.6773;69.127;44.3296;62.472;48.9329 3 3 3 100359982;170945;140668 MPC2_33219;CHRNA2_32401;ABCC3_7941 44.651700000000005 46.8463 6.138534310403378 36.200833333333335 35.8494 5.484301438044179 60.1773 62.472 10.290755791971694 46.8463;49.3913;37.7175 35.8494;41.8524;30.9007 69.127;62.472;48.9329 3 29573;29482;81678 SLC37A4_9871;SLC1A2_33059;ITPR2_8931 28.283733333333334 31.8111 13.54550363047949 18.844939999999998 22.6911 8.492783191321916 43.01343333333333 44.3296 17.714758616005255 39.7166;13.3235;31.8111 22.6911;9.10952;24.7342 60.0334;24.6773;44.3296 0 Exp 2,3(0.5);Linear,1(0.17);Poly 2,2(0.34) 2.0547531675186392 12.660532116889954 1.620316982269287 3.0381598472595215 0.5560684103076882 1.9079822897911072 26.070536807679602 46.864896525653734 18.35582322436035 36.68995010897299 38.786089939116195 64.40464339421713 CONFLICT 0.5 0.5 0.0 GO:0019637 4 organophosphate metabolic process 156 173 33 33 20 29 17 17 145 156 2229 0.97667 0.044101 0.073104 9.83 360268;298490;24651;25513;294103;100359982;25675;298541;83842;497840;362866;25028;192272;170570;50559;170465;296925 sult1e1;ppcs;pklr;pik3r1;papss2;mpc2;hmgcr;dhdds;crot;cps1;chpt1;ampd1;acot2;acot12;acot1;acaa2;aass SULT1E1_32446;PPCS_9540;PKLR_9489;PIK3R1_32562;PAPSS2_33237;MPC2_33219;HMGCR_8810;DHDDS_8467;CROT_8384;CPS1_32421;CHPT1_33298;AMPD1_32743;ACOT2_7969;ACOT12_32718;ACOT1_7968;ACAA2_7955;AASS_7936 28.454384705882347 27.4644 1.63089 16.21752915932832 31.137732429810306 14.249435461862255 21.958468647058826 21.7498 0.663137 12.924842361363535 24.35612326615635 11.641004214349426 41.7501705882353 37.2719 7.6286 23.238688593802053 44.462147179385376 20.304193058498548 7.5 27.0258 50.1846;20.3353;23.0963;18.7324;34.4443;46.8463;1.63089;47.9438;7.4229;31.9826;16.0559;60.9045;8.54905;30.3423;31.2018;26.5872;27.4644 36.5009;16.7643;17.4625;11.6701;25.719;35.8494;0.663137;36.5688;5.75707;24.4836;10.6021;50.0633;7.19676;24.0157;26.858;21.3695;21.7498 80.9788;25.6711;32.9443;41.5978;51.1014;69.127;7.6286;71.3742;10.316;45.5891;29.905;82.6625;10.4125;41.1025;37.2719;35.0407;37.0295 12 5 12 360268;298490;100359982;298541;83842;362866;25028;192272;170570;50559;170465;296925 SULT1E1_32446;PPCS_9540;MPC2_33219;DHDDS_8467;CROT_8384;CHPT1_33298;AMPD1_32743;ACOT2_7969;ACOT12_32718;ACOT1_7968;ACAA2_7955;AASS_7936 31.15317083333333 28.903350000000003 17.13496520630018 24.441302499999995 22.88275 13.479877042548297 44.240975 37.1507 25.62333109063354 50.1846;20.3353;46.8463;47.9438;7.4229;16.0559;60.9045;8.54905;30.3423;31.2018;26.5872;27.4644 36.5009;16.7643;35.8494;36.5688;5.75707;10.6021;50.0633;7.19676;24.0157;26.858;21.3695;21.7498 80.9788;25.6711;69.127;71.3742;10.316;29.905;82.6625;10.4125;41.1025;37.2719;35.0407;37.0295 5 24651;25513;294103;25675;497840 PKLR_9489;PIK3R1_32562;PAPSS2_33237;HMGCR_8810;CPS1_32421 21.977297999999998 23.0963 13.05076677812534 15.999667399999998 17.4625 10.2778491955717 35.77224 41.5978 17.068631703888858 23.0963;18.7324;34.4443;1.63089;31.9826 17.4625;11.6701;25.719;0.663137;24.4836 32.9443;41.5978;51.1014;7.6286;45.5891 0 Exp 2,11(0.65);Exp 4,1(0.06);Linear,2(0.12);Poly 2,3(0.18) 3.098246250746904 389.2677798271179 1.571676254272461 344.14306640625 82.82209440338818 1.9017701148986816 20.745060706325166 36.16370870543955 15.814388594664443 28.10254869945321 30.703199256515227 52.79714191995536 UP 0.7058823529411765 0.29411764705882354 0.0 GO:0098754 2 detoxification 44 58 8 8 8 8 8 8 154 50 2335 0.99025 0.028226 0.028226 13.79 24314;24567;24464;81869;29328;24360;312382;25303 nqo1;mt1;hp;gstm7;gpx4;fabp1;abcg2;abcc2 NQO1_33055;MT1A_9255;HP_8823;GSTM7_8761;GPX4_32827;FABP1_33091;ABCG2_32656;ABCC2_32541 42.333504999999995 44.1178 5.21654 26.38349611903353 38.10607446644753 24.114343670651955 29.653651249999996 31.291150000000002 2.73368 18.119083329140217 26.40336515219541 16.3329593036659 79.02005 67.51415 11.386 61.20924834873521 69.20147236430691 51.79375655456678 1.5 23.38965 4.5 46.076 87.2765;12.9315;64.9285;42.3152;45.9204;33.8478;5.21654;46.2316 60.6992;8.91033;41.6103;31.4035;34.2198;26.4736;2.73368;31.1788 197.117;23.4636;136.455;64.5991;70.4292;46.9257;11.386;81.7848 5 3 5 24314;81869;29328;24360;312382 NQO1_33055;GSTM7_8761;GPX4_32827;FABP1_33091;ABCG2_32656 42.915288 42.3152 29.498825710724823 31.105956 31.4035 20.688096908988033 78.0914 64.5991 70.40730815962928 87.2765;42.3152;45.9204;33.8478;5.21654 60.6992;31.4035;34.2198;26.4736;2.73368 197.117;64.5991;70.4292;46.9257;11.386 3 24567;24464;25303 MT1A_9255;HP_8823;ABCC2_32541 41.36386666666667 46.2316 26.33805465677626 27.233143333333334 31.1788 16.70323814111004 80.5678 81.7848 56.50553012971385 12.9315;64.9285;46.2316 8.91033;41.6103;31.1788 23.4636;136.455;81.7848 0 Exp 2,5(0.63);Exp 4,1(0.13);Linear,1(0.13);Poly 2,1(0.13) 1.738281466351683 14.023423910140991 1.5074360370635986 2.273383855819702 0.2520597597883215 1.6918878555297852 24.050674963165985 60.616335036834 17.097767092899215 42.20953540710079 36.60420491285229 121.43589508714771 UP 0.625 0.375 0.0 GO:0048584 5 positive regulation of response to stimulus 502 537 37 37 33 33 29 29 133 508 1877 0.17762 0.87098 0.37001 5.4 24825;293615;25106;29441;85253;25513;25591;25493;100359982;24539;24516;63868;24471;25675;81869;29455;299626;25112;289388;294515;25661;361969;24890;29496;25423;113936;29184;313421;246142 tf;sirt3;rgn;por;plg;pik3r1;parp1;nfkbia;mpc2;lpl;jun;hspd1;hspb1;hmgcr;gstm7;gdf15;gadd45b;gadd45a;g0s2;foxo3;fn1;fga;esr1;erbb3;ctsc;cpb2;cd36;c8b;bmf TF_10003;SIRT3_9828;RGN_9699;POR_9531;PLG_9501;PIK3R1_32562;PARP1_9425;NFKBIA_9307;MPC2_33219;LPL_32544;JUN_8938;HSPD1_8849;HSPB1_8847;HMGCR_8810;GSTM7_8761;GDF15_33113;GADD45B_8679;GADD45A_8678;G0S2_32729;FOXO3_8662;FN1_8655;FGA_8632;ESR1_33192;ERBB3_8571;CTSC_32456;CPB2_8369;CD36_8243;C8B_8181;BMF_8152 46.90416968965517 45.1539 0.520151 32.45948527368623 55.038886625898535 30.360225266545577 32.948966862068964 31.0499 0.160202 24.192471992212727 39.42484780191144 24.25973000511889 72.63754344827586 69.1421 2.88499 42.66507690308159 85.52751332886542 40.437500427769734 25.5 98.89785 45.1539;2.38018;77.4407;12.4414;70.7857;18.7324;26.9741;0.520151;46.8463;74.2041;16.4324;42.2579;89.1011;1.63089;42.3152;105.149;106.367;102.919;46.3784;13.1992;59.5777;28.5803;23.3972;60.9984;56.2386;25.8316;48.1296;21.3618;94.8767 28.132;0.56209;58.7732;8.48981;46.2356;11.6701;21.799;0.160202;35.8494;49.8682;10.5224;23.9469;60.3265;0.663137;31.4035;85.3487;52.7132;89.5012;33.7914;5.6804;31.0499;22.529;18.3088;41.6036;38.2681;20.4374;37.5433;17.2088;73.1342 61.5341;8.82917;89.8047;79.2355;150.579;41.5978;35.2797;2.88499;69.127;155.425;39.929;102.383;106.138;7.6286;64.5991;125.652;109.434;115.437;73.6529;32.7581;105.243;38.8511;31.9156;113.972;102.888;34.8042;69.1421;27.9161;109.848 13 16 13 24825;293615;25106;25591;100359982;24539;63868;81869;299626;289388;29496;29184;246142 TF_10003;SIRT3_9828;RGN_9699;PARP1_9425;MPC2_33219;LPL_32544;HSPD1_8849;GSTM7_8761;GADD45B_8679;G0S2_32729;ERBB3_8571;CD36_8243;BMF_8152 54.94788307692307 46.8463 27.838182023084602 37.62461461538462 35.8494 18.392527135423144 81.77159769230768 73.6529 37.72310487787387 45.1539;2.38018;77.4407;26.9741;46.8463;74.2041;42.2579;42.3152;106.367;46.3784;60.9984;48.1296;94.8767 28.132;0.56209;58.7732;21.799;35.8494;49.8682;23.9469;31.4035;52.7132;33.7914;41.6036;37.5433;73.1342 61.5341;8.82917;89.8047;35.2797;69.127;155.425;102.383;64.5991;109.434;73.6529;113.972;69.1421;109.848 16 29441;85253;25513;25493;24516;24471;25675;29455;25112;294515;25661;361969;24890;25423;113936;313421 POR_9531;PLG_9501;PIK3R1_32562;NFKBIA_9307;JUN_8938;HSPB1_8847;HMGCR_8810;GDF15_33113;GADD45A_8678;FOXO3_8662;FN1_8655;FGA_8632;ESR1_33192;CTSC_32456;CPB2_8369;C8B_8181 40.3686525625 24.614400000000003 35.28664681024584 29.150003062499998 19.3731 28.063241791149174 65.216124375 40.763400000000004 46.134883875763386 12.4414;70.7857;18.7324;0.520151;16.4324;89.1011;1.63089;105.149;102.919;13.1992;59.5777;28.5803;23.3972;56.2386;25.8316;21.3618 8.48981;46.2356;11.6701;0.160202;10.5224;60.3265;0.663137;85.3487;89.5012;5.6804;31.0499;22.529;18.3088;38.2681;20.4374;17.2088 79.2355;150.579;41.5978;2.88499;39.929;106.138;7.6286;125.652;115.437;32.7581;105.243;38.8511;31.9156;102.888;34.8042;27.9161 0 Exp 2,8(0.28);Exp 3,1(0.04);Exp 4,3(0.11);Hill,1(0.04);Linear,5(0.18);Poly 2,9(0.32);Power,2(0.07) 1.785500579000493 52.381707072257996 1.5122476816177368 2.6703107357025146 0.2946373472444895 1.7198865413665771 35.09012250355279 58.71821687575756 24.143805496920688 41.75412822721725 57.10903991589523 88.16604698065646 CONFLICT 0.4482758620689655 0.5517241379310345 0.0 GO:0002791 7 regulation of peptide secretion 138 149 21 21 15 19 13 13 149 136 2249 0.91307 0.14799 0.22441 8.72 293615;81819;25591;100359982;24539;63868;25675;113965;24957;25661;361969;65210;29184 sirt3;pax8;parp1;mpc2;lpl;hspd1;hmgcr;hadh;glul;fn1;fga;cyp2j4;cd36 SIRT3_9828;PAX8_9432;PARP1_9425;MPC2_33219;LPL_32544;HSPD1_8849;HMGCR_8810;HADH_8776;GLUL_32832;FN1_8655;FGA_8632;CYP2J4_32580;CD36_8243 35.77639 33.3125 1.63089 21.662595999762672 40.51330372835407 20.232498410507738 25.412032846153846 23.9469 0.56209 14.896248075905008 28.545637635659187 13.42357441123819 59.88525153846154 46.9856 7.6286 42.98388990437422 67.66375135416314 43.0193399572926 6.5 37.7852 2.38018;56.8931;26.9741;46.8463;74.2041;42.2579;1.63089;33.3125;26.4669;59.5777;28.5803;17.8395;48.1296 0.56209;45.1162;21.799;35.8494;49.8682;23.9469;0.663137;25.7336;21.0456;31.0499;22.529;14.6501;37.5433 8.82917;81.5688;35.2797;69.127;155.425;102.383;7.6286;46.9856;35.4303;105.243;38.8511;22.6149;69.1421 9 4 9 293615;81819;25591;100359982;24539;63868;113965;65210;29184 SIRT3_9828;PAX8_9432;PARP1_9425;MPC2_33219;LPL_32544;HSPD1_8849;HADH_8776;CYP2J4_32580;CD36_8243 38.759697777777774 42.2579 21.44833272774471 28.340976666666663 25.7336 15.46730045892463 65.70614111111111 69.127 44.774252556267896 2.38018;56.8931;26.9741;46.8463;74.2041;42.2579;33.3125;17.8395;48.1296 0.56209;45.1162;21.799;35.8494;49.8682;23.9469;25.7336;14.6501;37.5433 8.82917;81.5688;35.2797;69.127;155.425;102.383;46.9856;22.6149;69.1421 4 25675;24957;25661;361969 HMGCR_8810;GLUL_32832;FN1_8655;FGA_8632 29.063947499999998 27.523600000000002 23.73914001567226 18.821909249999997 21.787300000000002 12.883478952904856 46.78825 37.1407 41.40224375566297 1.63089;26.4669;59.5777;28.5803 0.663137;21.0456;31.0499;22.529 7.6286;35.4303;105.243;38.8511 0 Exp 2,5(0.39);Exp 3,1(0.08);Exp 4,1(0.08);Hill,1(0.08);Linear,4(0.31);Power,1(0.08) 1.996537445485808 26.8430814743042 1.5209722518920898 3.8079800605773926 0.6228472144368329 1.9017701148986816 24.00046867322011 47.552311326779886 17.31434015004413 33.50972554226356 36.518942817271125 83.25156025965197 UP 0.6923076923076923 0.3076923076923077 0.0 GO:0019915 4 lipid storage 15 17 3 3 2 3 2 2 160 15 2370 0.91096 0.295 0.295 11.76 298199;29184 plin2;cd36 PLIN2_9502;CD36_8243 36.89065 36.89065 25.6517 15.894275516833098 45.07623733372173 10.891295341190059 29.234250000000003 29.234250000000003 20.9252 11.750771200436153 35.28592337120109 8.05202599484073 51.0898 51.0898 33.0375 25.529807492027842 64.23770778716379 17.49388785320401 0.0 25.6517 0.5 36.89065 25.6517;48.1296 20.9252;37.5433 33.0375;69.1421 2 0 2 298199;29184 PLIN2_9502;CD36_8243 36.89065 36.89065 15.894275516833098 29.234250000000003 29.234250000000003 11.750771200436153 51.0898 51.0898 25.529807492027842 25.6517;48.1296 20.9252;37.5433 33.0375;69.1421 0 0 Exp 2,2(1) 2.451015153432874 4.920039653778076 2.2497289180755615 2.6703107357025146 0.2973962552877824 2.460019826889038 14.862308000000002 58.918992 12.948512000000001 45.519988000000005 15.707292000000002 86.472308 UP 1.0 0.0 0.0 GO:0007275 3 multicellular organism development 107 118 8 8 7 7 6 6 156 112 2273 0.36582 0.77452 0.70034 5.08 79426;29482;303612;81819;29328;29496 zfp36;slc1a2;polg2;pax8;gpx4;erbb3 ZFP36_10204;SLC1A2_33059;POLG2_9521;PAX8_9432;GPX4_32827;ERBB3_8571 40.209889 51.40675 0.348134 26.87114155054835 45.08962183061606 23.720789183115752 28.520420333333334 37.58755 0.118102 19.063962821526502 32.54067077181611 17.256421724848032 70.72898666666667 75.999 1.15962 50.541357606525246 77.1347072938661 44.1429017531837 4.5 62.3871 0.348134;13.3235;63.7758;56.8931;45.9204;60.9984 0.118102;9.10952;40.9553;45.1162;34.2198;41.6036 1.15962;24.6773;132.567;81.5688;70.4292;113.972 3 3 3 81819;29328;29496 PAX8_9432;GPX4_32827;ERBB3_8571 54.60396666666667 56.8931 7.795294706637641 40.313199999999995 41.6036 5.561630368875686 88.65666666666665 81.5688 22.62017348238814 56.8931;45.9204;60.9984 45.1162;34.2198;41.6036 81.5688;70.4292;113.972 3 79426;29482;303612 ZFP36_10204;SLC1A2_33059;POLG2_9521 25.815811333333333 13.3235 33.508365901496674 16.72764066666667 9.10952 21.458005662030224 52.80130666666667 24.6773 70.07278139803026 0.348134;13.3235;63.7758 0.118102;9.10952;40.9553 1.15962;24.6773;132.567 0 Exp 2,3(0.5);Hill,1(0.17);Linear,1(0.17);Poly 2,1(0.17) 1.6629153219723998 10.01023805141449 1.547789216041565 1.9381765127182007 0.15170599533401563 1.6108098030090332 18.708497702385277 61.711280297614735 13.266073079877852 43.77476758678881 30.28747789911676 111.17049543421658 CONFLICT 0.5 0.5 0.0 GO:0031331 7 positive regulation of cellular catabolic process 107 115 11 11 9 8 6 6 156 109 2276 0.39359 0.75262 0.84401 5.22 79426;246273;25106;294515;24360;25423 zfp36;trib3;rgn;foxo3;fabp1;ctsc ZFP36_10204;TRIB3_10079;RGN_9699;FOXO3_8662;FABP1_33091;CTSC_32456 48.189738999999996 45.0432 0.348134 40.55657336581392 55.910547804374936 34.538531572696016 35.53283366666667 32.37085 0.118102 31.977597294713703 41.28992447776645 27.167098838015203 69.49401999999999 68.3652 1.15962 52.00454235962855 81.38343078015794 45.099297197356854 4.5 92.75235 0.348134;108.064;77.4407;13.1992;33.8478;56.2386 0.118102;83.8836;58.7732;5.6804;26.4736;38.2681 1.15962;143.428;89.8047;32.7581;46.9257;102.888 2 4 2 25106;24360 RGN_9699;FABP1_33091 55.64425 55.64425 30.824835201587067 42.623400000000004 42.623400000000004 22.839266189613 68.3652 68.3652 30.32003167049796 77.4407;33.8478 58.7732;26.4736 89.8047;46.9257 4 79426;246273;294515;25423 ZFP36_10204;TRIB3_10079;FOXO3_8662;CTSC_32456 44.4624835 34.7189 48.67339638834499 31.987550499999998 21.974249999999998 38.472384775109376 70.05843 67.82305 64.80543985884415 0.348134;108.064;13.1992;56.2386 0.118102;83.8836;5.6804;38.2681 1.15962;143.428;32.7581;102.888 0 Exp 2,2(0.34);Exp 4,1(0.17);Hill,1(0.17);Poly 2,2(0.34) 1.8231022498806029 10.972524285316467 1.5736411809921265 1.9883413314819336 0.15419948384913235 1.8762393593788147 15.737721582415105 80.6417564175849 9.94542678639758 61.12024054693576 27.881719591239147 111.10632040876087 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0044092 4 negative regulation of molecular function 276 297 39 39 35 36 32 32 130 265 2120 0.99934 0.0013929 0.0021309 10.77 79426;246273;79224;24794;24648;25106;252922;83516;29441;24314;81525;25493;299282;288001;24516;54404;50693;306251;24471;24464;25675;81869;299626;25112;83928;24360;24890;116663;114851;79431;25377;25373 zfp36;trib3;serpind1;serpina3c;serpina1;rgn;pzp;ppargc1a;por;nqo1;nfkbib;nfkbia;loc299282;kng1;jun;itih4;itih3;itih1;hspb1;hp;hmgcr;gstm7;gadd45b;gadd45a;fetub;fabp1;esr1;dusp6;cdkn1a;bhlhe40;ambp;ahsg ZFP36_10204;TRIB3_10079;SERPIND1_9812;SERPINA3C_32925;SERPINA1_9807;RGN_9699;PZP_9633;PPARGC1A_33189;POR_9531;NQO1_33055;NFKBIB_9308;NFKBIA_9307;LOC299282_9119;KNG1L1_34113;JUN_8938;ITIH4_32725;ITIH3_32422;ITIH1_33132;HSPB1_8847;HP_8823;HMGCR_8810;GSTM7_8761;GADD45B_8679;GADD45A_8678;FETUB_33027;FABP1_33091;ESR1_33192;DUSP6_8506;CDKN1A_8271;BHLHE40_8141;AMBP_33085;AHSG_8003 43.39354203125001 33.181650000000005 0.348134 33.068289749471084 48.63164305832191 32.3076874622788 29.919346906250002 25.271349999999998 0.118102 22.701049430732642 33.478177132999726 23.439435988183778 67.0748565625 49.27705 1.15962 48.0907496448276 73.81661908609816 41.30753831183873 13.5 30.1616 28.5 100.54655 0.348134;108.064;28.261;29.766;15.797;77.4407;34.1871;42.4094;12.4414;87.2765;30.5572;0.520151;45.2017;24.3655;16.4324;57.1163;27.1247;98.1741;89.1011;64.9285;1.63089;42.3152;106.367;102.919;32.5155;33.8478;23.3972;62.3934;6.24967;57.8085;17.2343;12.402 0.118102;83.8836;22.307;23.347;13.013;58.7732;26.3085;26.2988;8.48981;60.6992;24.2439;0.160202;30.7472;19.538;10.5224;39.6402;21.5108;42.9071;60.3265;41.6103;0.663137;31.4035;52.7132;89.5012;19.6094;26.4736;18.3088;39.0875;2.44025;38.3491;14.1233;10.3013 1.15962;143.428;38.3264;40.8256;19.9134;89.8047;48.5666;81.7305;79.2355;197.117;41.2611;2.88499;78.6415;32.1467;39.929;101.869;36.4819;104.278;106.138;136.455;7.6286;64.5991;109.434;115.437;49.9875;46.9257;31.9156;133.304;19.0606;110.58;21.9073;15.4235 6 26 6 25106;24314;81525;81869;299626;24360 RGN_9699;NQO1_33055;NFKBIB_9308;GSTM7_8761;GADD45B_8679;FABP1_33091 62.967400000000005 59.87795 31.65065423936761 42.384433333333334 42.058350000000004 16.813805254096017 91.5236 77.2019 57.816820147496834 77.4407;87.2765;30.5572;42.3152;106.367;33.8478 58.7732;60.6992;24.2439;31.4035;52.7132;26.4736 89.8047;197.117;41.2611;64.5991;109.434;46.9257 26 79426;246273;79224;24794;24648;252922;83516;29441;25493;299282;288001;24516;54404;50693;306251;24471;24464;25675;25112;83928;24890;116663;114851;79431;25377;25373 ZFP36_10204;TRIB3_10079;SERPIND1_9812;SERPINA3C_32925;SERPINA1_9807;PZP_9633;PPARGC1A_33189;POR_9531;NFKBIA_9307;LOC299282_9119;KNG1L1_34113;JUN_8938;ITIH4_32725;ITIH3_32422;ITIH1_33132;HSPB1_8847;HP_8823;HMGCR_8810;GADD45A_8678;FETUB_33027;ESR1_33192;DUSP6_8506;CDKN1A_8271;BHLHE40_8141;AMBP_33085;AHSG_8003 38.87649788461538 29.0135 32.28667492860213 27.042788500000004 21.9089 23.164228624889315 61.43283884615385 44.6961 44.973910209306574 0.348134;108.064;28.261;29.766;15.797;34.1871;42.4094;12.4414;0.520151;45.2017;24.3655;16.4324;57.1163;27.1247;98.1741;89.1011;64.9285;1.63089;102.919;32.5155;23.3972;62.3934;6.24967;57.8085;17.2343;12.402 0.118102;83.8836;22.307;23.347;13.013;26.3085;26.2988;8.48981;0.160202;30.7472;19.538;10.5224;39.6402;21.5108;42.9071;60.3265;41.6103;0.663137;89.5012;19.6094;18.3088;39.0875;2.44025;38.3491;14.1233;10.3013 1.15962;143.428;38.3264;40.8256;19.9134;48.5666;81.7305;79.2355;2.88499;78.6415;32.1467;39.929;101.869;36.4819;104.278;106.138;136.455;7.6286;115.437;49.9875;31.9156;133.304;19.0606;110.58;21.9073;15.4235 0 Exp 2,12(0.38);Exp 3,1(0.04);Exp 4,3(0.1);Hill,1(0.04);Linear,7(0.22);Poly 2,7(0.22);Power,1(0.04) 1.819901355555668 59.36567521095276 1.5197933912277222 3.431420087814331 0.41615735615770477 1.7035366892814636 31.935964188444622 54.85111987405538 22.05383456991419 37.78485924258581 50.412261921260935 83.73745120373904 DOWN 0.1875 0.8125 0.0 GO:0044270 5 cellular nitrogen compound catabolic process 51 59 7 7 6 6 5 5 157 54 2331 0.83086 0.32055 0.42152 8.47 79426;29441;24443;308441;25287 zfp36;por;hdc;exosc5;acadl ZFP36_10204;POR_9531;HDC_8788;EXOSC5_32543;ACADL_32776 22.5569468 24.5745 0.348134 16.541895961858522 18.111880752207096 14.54742677378913 17.6014624 21.0619 0.118102 13.052068079479158 13.706655140805028 11.740306681703778 43.427044 45.3228 1.15962 30.093965661884447 53.495457617836315 32.48648480630089 1.5 18.50795 0.348134;12.4414;24.5745;41.9329;33.4878 0.118102;8.48981;21.0619;31.7336;26.6039 1.15962;79.2355;29.28;62.1373;45.3228 3 2 3 24443;308441;25287 HDC_8788;EXOSC5_32543;ACADL_32776 33.33173333333333 33.4878 8.680252314497162 26.466466666666665 26.6039 5.337177265496567 45.58003333333334 45.3228 16.43016030242349 24.5745;41.9329;33.4878 21.0619;31.7336;26.6039 29.28;62.1373;45.3228 2 79426;29441 ZFP36_10204;POR_9531 6.394767 6.394767 8.551230395292714 4.303956 4.303956 5.91969149691367 40.19756 40.19756 55.207984195107144 0.348134;12.4414 0.118102;8.48981 1.15962;79.2355 0 Exp 2,3(0.6);Hill,1(0.2);Poly 2,1(0.2) 2.8936595204719535 24.918370485305786 1.5979743003845215 17.513065338134766 7.005749994154267 1.9381765127182007 8.057335691801594 37.0565579081984 6.160820302713152 29.042104497286847 17.048520050452915 69.80556794954708 UP 0.6 0.4 0.0 GO:0050710 6 negative regulation of cytokine secretion 13 14 4 4 2 4 2 2 160 12 2373 0.94527 0.22236 0.22236 14.29 25591;25661 parp1;fn1 PARP1_9425;FN1_8655 43.2759 43.2759 26.9741 23.05422665109372 45.30808770380435 22.874391636784857 26.42445 26.42445 21.799 6.541374122078636 27.001060105298915 6.490347985889065 70.26135 70.26135 35.2797 49.47152386418878 74.62217389605978 49.085620127896 0.0 26.9741 0.5 43.2759 26.9741;59.5777 21.799;31.0499 35.2797;105.243 1 1 1 25591 PARP1_9425 26.9741 26.9741 21.799 21.799 35.2797 35.2797 26.9741 21.799 35.2797 1 25661 FN1_8655 59.5777 59.5777 31.0499 31.0499 105.243 105.243 59.5777 31.0499 105.243 0 Exp 2,1(0.5);Power,1(0.5) 1.7938912541568988 3.5879032611846924 1.7792335748672485 1.8086696863174438 0.020814474018196083 1.7939516305923462 11.324372000000004 75.227428 17.358567999999998 35.490332 1.6973160000000007 138.82538399999999 CONFLICT 0.5 0.5 0.0 GO:0018193 7 peptidyl-amino acid modification 169 184 8 8 5 7 4 4 158 180 2205 0.0063045 0.99824 0.011458 2.17 293615;29441;25591;29496 sirt3;por;parp1;erbb3 SIRT3_9828;POR_9531;PARP1_9425;ERBB3_8571 25.698520000000002 19.70775 2.38018 25.607322152077256 26.760080265574686 24.71333655983214 18.113625 15.144404999999999 0.56209 17.944684546328293 19.08249478471753 17.26775701485866 59.3290925 57.2576 8.82917 46.58586284748722 59.9343463892975 45.07443109427931 2.38018;12.4414;26.9741;60.9984 0.56209;8.48981;21.799;41.6036 8.82917;79.2355;35.2797;113.972 3 1 3 293615;25591;29496 SIRT3_9828;PARP1_9425;ERBB3_8571 30.117559999999997 26.9741 29.435266850681003 21.321563333333334 21.799 20.524920099674766 52.693623333333335 35.2797 54.691747270466976 2.38018;26.9741;60.9984 0.56209;21.799;41.6036 8.82917;35.2797;113.972 1 29441 POR_9531 12.4414 12.4414 8.48981 8.48981 79.2355 79.2355 12.4414 8.48981 79.2355 0 Exp 2,1(0.25);Hill,1(0.25);Linear,1(0.25);Poly 2,1(0.25) 1.7189390028029732 6.912872672080994 1.5209722518920898 1.9819281101226807 0.20808620541133624 1.7049861550331116 0.6033442909642872 50.79369570903571 0.5278341445982768 35.699415855401725 13.67494690946252 104.98323809053748 UP 0.75 0.25 0.0 GO:0048870 3 cell motility 193 205 11 11 6 10 6 6 156 199 2186 0.018282 0.99308 0.035562 2.93 29573;85253;25493;494344;25661;140942 slc37a4;plg;nfkbia;ier2;fn1;ddit4 SLC37A4_9871;PLG_9501;NFKBIA_9307;IER2_32643;FN1_8655;DDIT4_8450 51.30394183333333 54.629549999999995 0.520151 29.92353798247962 55.128268486199225 18.310104637450234 31.140783666666664 32.25625 0.160202 18.724613789694057 33.12276266521981 12.141880081785107 108.945465 97.3417 2.88499 82.96225373580776 106.02856477629383 53.24836852237042 39.7166;70.7857;0.520151;49.6814;59.5777;87.5421 22.6911;46.2356;0.160202;33.4626;31.0499;53.2453 60.0334;150.579;2.88499;89.4404;105.243;245.492 0 6 0 6 29573;85253;25493;494344;25661;140942 SLC37A4_9871;PLG_9501;NFKBIA_9307;IER2_32643;FN1_8655;DDIT4_8450 51.30394183333333 54.629549999999995 29.92353798247962 31.140783666666664 32.25625 18.724613789694057 108.945465 97.3417 82.96225373580776 39.7166;70.7857;0.520151;49.6814;59.5777;87.5421 22.6911;46.2356;0.160202;33.4626;31.0499;53.2453 60.0334;150.579;2.88499;89.4404;105.243;245.492 0 Exp 2,1(0.17);Exp 4,1(0.17);Linear,2(0.34);Poly 2,1(0.17);Power,1(0.17) 1.7430489172172725 10.484898447990417 1.5254690647125244 1.893584966659546 0.13406089189346387 1.772010862827301 27.3601247104169 75.24775895624978 16.15797219095887 46.12359514237447 42.561836409081394 175.3290935909186 DOWN 0.0 1.0 0.0 GO:1990962 7 xenobiotic transport across blood-brain barrier 3 3 3 3 3 2 2 2 160 1 2384 0.99975 0.011561 0.011561 66.67 312382;25303 abcg2;abcc2 ABCG2_32656;ABCC2_32541 25.72407 25.72407 5.21654 29.002027056773123 18.16180033972052 26.95814772146323 16.95624 16.95624 2.73368 20.113737243665085 11.711589182495189 18.69624832719367 46.5854 46.5854 11.386 49.77946886739552 33.605418759936406 46.27132691781375 0.0 5.21654 0.0 5.21654 5.21654;46.2316 2.73368;31.1788 11.386;81.7848 1 1 1 312382 ABCG2_32656 5.21654 5.21654 2.73368 2.73368 11.386 11.386 5.21654 2.73368 11.386 1 25303 ABCC2_32541 46.2316 46.2316 31.1788 31.1788 81.7848 81.7848 46.2316 31.1788 81.7848 0 Exp 2,1(0.5);Exp 4,1(0.5) 1.6739989573219825 3.3664021492004395 1.5074360370635986 1.8589661121368408 0.24856929987530568 1.6832010746002197 -14.470688799999998 65.9188288 -10.919977599999992 44.8324576 -22.405423999999996 115.57622400000001 CONFLICT 0.5 0.5 0.0 GO:0034763 6 negative regulation of transmembrane transport 25 28 3 3 3 2 2 2 160 26 2359 0.73822 0.5404 0.6976 7.14 81869;24890 gstm7;esr1 GSTM7_8761;ESR1_33192 32.8562 32.8562 23.3972 13.377046086487086 37.49786943990492 11.655692670163587 24.85615 24.85615 18.3088 9.259351167603496 28.069030262962414 8.067861233110845 48.25735 48.25735 31.9156 23.11072448291054 56.27648538107265 20.136844877116612 0.5 32.8562 42.3152;23.3972 31.4035;18.3088 64.5991;31.9156 1 1 1 81869 GSTM7_8761 42.3152 42.3152 31.4035 31.4035 64.5991 64.5991 42.3152 31.4035 64.5991 1 24890 ESR1_33192 23.3972 23.3972 18.3088 18.3088 31.9156 31.9156 23.3972 18.3088 31.9156 0 Exp 2,1(0.5);Linear,1(0.5) 2.0652113715138007 4.187138915061951 1.7501527070999146 2.436986207962036 0.4856646260057026 2.0935694575309753 14.316560000000006 51.39583999999999 12.023344 37.688956 16.22752 80.28718 CONFLICT 0.5 0.5 0.0 GO:0009636 4 response to toxic substance 240 257 39 39 31 35 27 27 135 230 2155 0.99755 0.0049606 0.0066673 10.51 286954;83516;25513;24314;25493;58954;24516;81678;63868;24471;24464;25675;314322;361969;24360;65030;25315;116636;24330;25428;25146;497840;170945;81718;114851;54232;25698 ugt2b1;ppargc1a;pik3r1;nqo1;nfkbia;klf6;jun;itpr2;hspd1;hspb1;hp;hmgcr;fos;fga;fabp1;ephx2;ephx1;eif4ebp1;egr1;cyp7a1;cyp17a1;cps1;chrna2;cdo1;cdkn1a;car3;ass1 UGT2B10_33303,UGT2B1_33224;PPARGC1A_33189;PIK3R1_32562;NQO1_33055;NFKBIA_9307;KLF6_8969;JUN_8938;ITPR2_8931;HSPD1_8849;HSPB1_8847;HP_8823;HMGCR_8810;FOS_8657;FGA_8632;FABP1_33091;EPHX2_33282;EPHX1_8567;EIF4EBP1_8550;EGR1_8533;CYP7A1_8430;CYP17A1_32365;CPS1_32421;CHRNA2_32401;CDO1_8275;CDKN1A_8271;CAR3_8196;ASS1_33159 33.576694740740784 31.8111 1.28141E-12 26.300181036249523 36.58863888419335 24.150830823053266 22.5334585555556 23.9469 1.28141E-12 17.492055384350184 24.700121223507818 15.671049273619058 56.8811155555556 45.5481 1.28142E-12 44.97919266006413 58.333910970767825 37.2710834032819 11.5 27.692 24.5 85.5883 47.47345;42.4094;18.7324;87.2765;0.520151;18.9476;16.4324;31.8111;42.2579;89.1011;64.9285;1.63089;1.28141E-12;28.5803;33.8478;38.7293;12.4747;83.9001;0.750017;5.72128;49.6922;31.9826;49.3913;22.9638;6.24967;53.9626;26.8037 34.82915;26.2988;11.6701;60.6992;0.160202;11.6941;10.5224;24.7342;23.9469;60.3265;41.6103;0.663137;1.28141E-12;22.529;26.4736;29.2097;7.00435;42.4185;0.186019;0.985273;35.6654;24.4836;41.8524;18.5144;2.44025;28.5034;20.9825 76.47475;81.7305;41.5978;197.117;2.88499;45.5481;39.929;44.3296;102.383;106.138;136.455;7.6286;1.28142E-12;38.8511;46.9257;57.2113;23.684;107.32;4.70178;22.3625;81.6409;45.5891;62.472;30.0179;19.0606;77.0288;36.7081 10 18 9 286954;24314;63868;24360;65030;25315;116636;25146;170945 UGT2B10_33303,UGT2B1_33224;NQO1_33055;HSPD1_8849;FABP1_33091;EPHX2_33282;EPHX1_8567;EIF4EBP1_8550;CYP17A1_32365;CHRNA2_32401 49.44925 47.47345 23.44910315305257 33.56657777777778 34.82915 14.817947613074475 83.91429444444444 76.47475 49.91612241747679 47.47345;87.2765;42.2579;33.8478;38.7293;12.4747;83.9001;49.6922;49.3913 34.82915;60.6992;23.9469;26.4736;29.2097;7.00435;42.4185;35.6654;41.8524 76.47475;197.117;102.383;46.9257;57.2113;23.684;107.32;81.6409;62.472 18 83516;25513;25493;58954;24516;81678;24471;24464;25675;314322;361969;24330;25428;497840;81718;114851;54232;25698 PPARGC1A_33189;PIK3R1_32562;NFKBIA_9307;KLF6_8969;JUN_8938;ITPR2_8931;HSPB1_8847;HP_8823;HMGCR_8810;FOS_8657;FGA_8632;EGR1_8533;CYP7A1_8430;CPS1_32421;CDO1_8275;CDKN1A_8271;CAR3_8196;ASS1_33159 25.64041711111118 20.9557 24.475847561339457 17.016898944444517 15.10425 16.369534565536675 43.36452611111118 39.39005 36.62421699001273 42.4094;18.7324;0.520151;18.9476;16.4324;31.8111;89.1011;64.9285;1.63089;1.28141E-12;28.5803;0.750017;5.72128;31.9826;22.9638;6.24967;53.9626;26.8037 26.2988;11.6701;0.160202;11.6941;10.5224;24.7342;60.3265;41.6103;0.663137;1.28141E-12;22.529;0.186019;0.985273;24.4836;18.5144;2.44025;28.5034;20.9825 81.7305;41.5978;2.88499;45.5481;39.929;44.3296;106.138;136.455;7.6286;1.28142E-12;38.8511;4.70178;22.3625;45.5891;30.0179;19.0606;77.0288;36.7081 0 Exp 2,9(0.33);Exp 3,2(0.08);Exp 4,3(0.11);Hill,4(0.15);Linear,5(0.18);Poly 2,5(0.18) 2.0596690784520417 61.413076639175415 1.522104263305664 4.642963409423828 0.9287971292932149 1.864974319934845 23.656209228077955 43.49718025340363 15.93541720413045 29.131499906980757 39.91486621527851 73.84736489583271 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:2001141 7 regulation of RNA biosynthetic process 476 510 36 36 28 30 25 25 137 485 1900 0.076677 0.94986 0.15499 4.9 79426;24522;246273;24825;293615;25106;83516;363465;25513;81819;25591;81525;25493;58954;24516;494344;290556;25112;294515;314322;24890;24330;25695;29184;79431 zfp36;zfp354a;trib3;tf;sirt3;rgn;ppargc1a;pir;pik3r1;pax8;parp1;nfkbib;nfkbia;klf6;jun;ier2;gnl3;gadd45a;foxo3;fos;esr1;egr1;cebpd;cd36;bhlhe40 ZFP36_10204;ZFP354A_10203;TRIB3_10079;TF_10003;SIRT3_9828;RGN_9699;PPARGC1A_33189;PIR_9487;PIK3R1_32562;PAX8_9432;PARP1_9425;NFKBIB_9308;NFKBIA_9307;KLF6_8969;JUN_8938;IER2_32643;GNL3_8735;GADD45A_8678;FOXO3_8662;FOS_8657;ESR1_33192;EGR1_8533;CEBPD_8283;CD36_8243;BHLHE40_8141 35.18185380000005 26.9741 1.28141E-12 32.96295085952626 38.04754734826778 32.09850638539458 25.581239888000056 21.799 1.28141E-12 25.76972597612126 28.747420923542812 26.347808188147205 57.80949280000005 41.5978 1.28142E-12 55.353075266780706 56.125215150943134 43.44986536839067 0.348134;0.834827;108.064;45.1539;2.38018;77.4407;42.4094;50.0307;18.7324;56.8931;26.9741;30.5572;0.520151;18.9476;16.4324;49.6814;87.6357;102.919;13.1992;1.28141E-12;23.3972;0.750017;0.306936;48.1296;57.8085 0.118102;0.27095;83.8836;28.132;0.56209;58.7732;26.2988;38.7717;11.6701;45.1162;21.799;24.2439;0.160202;11.6941;10.5224;33.4626;54.41;89.5012;5.6804;1.28141E-12;18.3088;0.186019;0.0732342;37.5433;38.3491 1.15962;2.99857;143.428;61.5341;8.82917;89.8047;81.7305;73.0083;41.5978;81.5688;35.2797;41.2611;2.88499;45.5481;39.929;89.4404;238.963;115.437;32.7581;1.28142E-12;31.9156;4.70178;1.73689;69.1421;110.58 9 16 9 24825;293615;25106;363465;81819;25591;81525;290556;29184 TF_10003;SIRT3_9828;RGN_9699;PIR_9487;PAX8_9432;PARP1_9425;NFKBIB_9308;GNL3_8735;CD36_8243 47.24390888888889 48.1296 25.863667175252075 34.37237666666667 37.5433 17.973934928116034 77.71010777777776 69.1421 65.56895050186137 45.1539;2.38018;77.4407;50.0307;56.8931;26.9741;30.5572;87.6357;48.1296 28.132;0.56209;58.7732;38.7717;45.1162;21.799;24.2439;54.41;37.5433 61.5341;8.82917;89.8047;73.0083;81.5688;35.2797;41.2611;238.963;69.1421 16 79426;24522;246273;83516;25513;25493;58954;24516;494344;25112;294515;314322;24890;24330;25695;79431 ZFP36_10204;ZFP354A_10203;TRIB3_10079;PPARGC1A_33189;PIK3R1_32562;NFKBIA_9307;KLF6_8969;JUN_8938;IER2_32643;GADD45A_8678;FOXO3_8662;FOS_8657;ESR1_33192;EGR1_8533;CEBPD_8283;BHLHE40_8141 28.39694781250008 17.5824 35.289200540627554 20.63622545000008 11.09625 28.59671833550186 46.61539687500008 36.34355 47.30861627705156 0.348134;0.834827;108.064;42.4094;18.7324;0.520151;18.9476;16.4324;49.6814;102.919;13.1992;1.28141E-12;23.3972;0.750017;0.306936;57.8085 0.118102;0.27095;83.8836;26.2988;11.6701;0.160202;11.6941;10.5224;33.4626;89.5012;5.6804;1.28141E-12;18.3088;0.186019;0.0732342;38.3491 1.15962;2.99857;143.428;81.7305;41.5978;2.88499;45.5481;39.929;89.4404;115.437;32.7581;1.28142E-12;31.9156;4.70178;1.73689;110.58 0 Exp 2,10(0.4);Exp 4,2(0.08);Hill,6(0.24);Poly 2,7(0.28) 1.943606019461897 50.83195424079895 1.5209722518920898 4.591650485992432 0.7611050467422757 1.8086696863174438 22.26037706306576 48.10333053693434 15.479507305360515 35.682972470639584 36.11108729542202 79.50789830457808 DOWN 0.36 0.64 0.0 GO:0010506 7 regulation of autophagy 61 65 4 4 4 3 3 3 159 62 2323 0.39794 0.79415 0.7963 4.62 246273;294515;246142 trib3;foxo3;bmf TRIB3_10079;FOXO3_8662;BMF_8152 72.04663333333333 94.8767 13.1992 51.388145790282536 88.9415106432901 34.13571668133207 54.232733333333336 73.1342 5.6804 42.38967096089958 68.19559882682657 28.1601648827912 95.34469999999999 109.848 32.7581 56.74254113687546 109.77504336179365 38.2988398215892 108.064;13.1992;94.8767 83.8836;5.6804;73.1342 143.428;32.7581;109.848 1 2 1 246142 BMF_8152 94.8767 94.8767 73.1342 73.1342 109.848 109.848 94.8767 73.1342 109.848 2 246273;294515 TRIB3_10079;FOXO3_8662 60.6316 60.6316 67.0795433759056 44.782000000000004 44.782000000000004 55.29801303048781 88.09305 88.09305 78.2554367632371 108.064;13.1992 83.8836;5.6804 143.428;32.7581 0 Exp 4,1(0.34);Poly 2,2(0.67) 1.8517348743226554 5.566655278205872 1.701177716255188 1.9883413314819336 0.14479348231515296 1.87713623046875 13.895472115189634 130.19779455147705 6.264304970668668 102.201161695998 31.134470056238257 159.55492994376175 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:2000182 7 regulation of progesterone biosynthetic process 2 2 2 2 2 2 2 2 160 0 2385 1.0 0.0040221 0.0040221 100.0 83516;24330 ppargc1a;egr1 PPARGC1A_33189;EGR1_8533 21.5797085 21.5797085 0.750017 29.457632219347577 20.160820930108887 29.389209109779756 13.2424095 13.2424095 0.186019 18.464524520739236 12.353027619903774 18.421635799236004 43.21614 43.21614 4.70178 54.467530258119844 40.59259914408712 54.34101507309108 0.0 0.750017 0.0 0.750017 42.4094;0.750017 26.2988;0.186019 81.7305;4.70178 0 2 0 2 83516;24330 PPARGC1A_33189;EGR1_8533 21.5797085 21.5797085 29.457632219347577 13.2424095 13.2424095 18.464524520739236 43.21614 43.21614 54.467530258119844 42.4094;0.750017 26.2988;0.186019 81.7305;4.70178 0 Exp 2,1(0.5);Hill,1(0.5) 2.7228947912715027 5.975908637046814 1.7576230764389038 4.21828556060791 1.73995112876724 2.987954318523407 -19.246486839999992 62.40590383999999 -12.348115879999995 38.832934879999996 -32.27200560000001 118.70428560000002 DOWN 0.0 1.0 0.0 GO:1901566 5 organonitrogen compound biosynthetic process 169 188 26 26 16 23 14 14 148 174 2211 0.78949 0.30558 0.53316 7.45 298490;24651;294103;100359982;364070;24443;24957;497840;362866;81718;25698;25028;24158;296925 ppcs;pklr;papss2;mpc2;iars2;hdc;glul;cps1;chpt1;cdo1;ass1;ampd1;acadm;aass PPCS_9540;PKLR_9489;PAPSS2_33237;MPC2_33219;IARS2_8858;HDC_8788;GLUL_32832;CPS1_32421;CHPT1_33298;CDO1_8275;ASS1_33159;AMPD1_32743;ACADM_7957;AASS_7936 28.455899999999996 25.59865 11.7137 12.511300908932146 29.317817051024015 13.74631264545652 22.318714999999997 21.01405 8.36151 10.309528047665983 22.936601336826094 11.492947956870186 39.79565 34.1873 18.9642 17.387321033741358 41.334260707975474 18.60083015806811 8.5 27.134050000000002 20.3353;23.0963;34.4443;46.8463;24.7304;24.5745;26.4669;31.9826;16.0559;22.9638;26.8037;60.9045;11.7137;27.4644 16.7643;17.4625;25.719;35.8494;19.8021;21.0619;21.0456;24.4836;10.6021;18.5144;20.9825;50.0633;8.36151;21.7498 25.6711;32.9443;51.1014;69.127;32.7087;29.28;35.4303;45.5891;29.905;30.0179;36.7081;82.6625;18.9642;37.0295 8 6 8 298490;100359982;364070;24443;362866;25028;24158;296925 PPCS_9540;MPC2_33219;IARS2_8858;HDC_8788;CHPT1_33298;AMPD1_32743;ACADM_7957;AASS_7936 29.078125 24.65245 16.552747877942025 23.03180125 20.432000000000002 13.731841314124562 40.668499999999995 31.30685 22.65118257726452 20.3353;46.8463;24.7304;24.5745;16.0559;60.9045;11.7137;27.4644 16.7643;35.8494;19.8021;21.0619;10.6021;50.0633;8.36151;21.7498 25.6711;69.127;32.7087;29.28;29.905;82.6625;18.9642;37.0295 6 24651;294103;24957;497840;81718;25698 PKLR_9489;PAPSS2_33237;GLUL_32832;CPS1_32421;CDO1_8275;ASS1_33159 27.626266666666666 26.6353 4.6849366922794875 21.36793333333333 21.01405 3.2337804363727023 38.63184999999999 36.0692 8.054714157994715 23.0963;34.4443;26.4669;31.9826;22.9638;26.8037 17.4625;25.719;21.0456;24.4836;18.5144;20.9825 32.9443;51.1014;35.4303;45.5891;30.0179;36.7081 0 Exp 2,8(0.58);Linear,4(0.29);Poly 2,2(0.15) 2.2606466195337385 42.93150091171265 1.571676254272461 17.513065338134766 4.170233857614624 1.9019047021865845 21.902079795031955 35.00972020496805 16.91825395168165 27.71917604831836 30.687614254504844 48.90368574549516 CONFLICT 0.5714285714285714 0.42857142857142855 0.0 GO:0050794 4 regulation of cellular process 1555 1680 132 131 105 116 94 94 68 1586 799 0.018144 0.9881 0.03198 5.6 257644;79426;24522;24856;308843;246273;25357;24825;360268;362895;170698;29482;293615;79224;24794;24648;297784;25106;308821;252922;192280;83516;29441;303612;85253;363465;25513;360722;81819;25591;24314;81525;25493;24567;100359982;24539;299282;307582;288001;58954;24516;81678;54404;50693;306251;25685;494344;192235;65164;63868;24471;24464;25675;113965;81869;29328;290556;24957;29455;299626;25112;289388;294515;314322;25661;246186;361969;83928;24360;24890;29496;116636;24330;116663;140942;25428;65210;25146;25423;113936;170945;25695;114851;29184;246142;79431;25698;25377;25373;50559;24158;25287;170465;25303 zwint;zfp36;zfp354a;ttr;tsku;trib3;thrsp;tf;sult1e1;stac3;slco1a2;slc1a2;sirt3;serpind1;serpina3c;serpina1;rrs1;rgn;rab30;pzp;ppp1r3b;ppargc1a;por;polg2;plg;pir;pik3r1;pdia5;pax8;parp1;nqo1;nfkbib;nfkbia;mt1;mpc2;lpl;loc299282;lama3;kng1;klf6;jun;itpr2;itih4;itih3;itih1;igfbp1;ier2;hyou1;htra1;hspd1;hspb1;hp;hmgcr;hadh;gstm7;gpx4;gnl3;glul;gdf15;gadd45b;gadd45a;g0s2;foxo3;fos;fn1;fgl1;fga;fetub;fabp1;esr1;erbb3;eif4ebp1;egr1;dusp6;ddit4;cyp7a1;cyp2j4;cyp17a1;ctsc;cpb2;chrna2;cebpd;cdkn1a;cd36;bmf;bhlhe40;ass1;ambp;ahsg;acot1;acadm;acadl;acaa2;abcc2 ZWINT_10214;ZFP36_10204;ZFP354A_10203;TTR_10102;TSKU_10094;TRIB3_10079;THRSP_33314;TF_10003;SULT1E1_32446;STAC3_9953;SLCO1A2_9886;SLC1A2_33059;SIRT3_9828;SERPIND1_9812;SERPINA3C_32925;SERPINA1_9807;RRS1_9755;RGN_9699;RAB30_9639;PZP_9633;PPP1R3B_9545;PPARGC1A_33189;POR_9531;POLG2_9521;PLG_9501;PIR_9487;PIK3R1_32562;PDIA5_9451;PAX8_9432;PARP1_9425;NQO1_33055;NFKBIB_9308;NFKBIA_9307;MT1A_9255;MPC2_33219;LPL_32544;LOC299282_9119;LAMA3_8980;KNG1L1_34113;KLF6_8969;JUN_8938;ITPR2_8931;ITIH4_32725;ITIH3_32422;ITIH1_33132;IGFBP1_32306;IER2_32643;HYOU1_8857;HTRA1_8856;HSPD1_8849;HSPB1_8847;HP_8823;HMGCR_8810;HADH_8776;GSTM7_8761;GPX4_32827;GNL3_8735;GLUL_32832;GDF15_33113;GADD45B_8679;GADD45A_8678;G0S2_32729;FOXO3_8662;FOS_8657;FN1_8655;FGL1_8640;FGA_8632;FETUB_33027;FABP1_33091;ESR1_33192;ERBB3_8571;EIF4EBP1_8550;EGR1_8533;DUSP6_8506;DDIT4_8450;CYP7A1_8430;CYP2J4_32580;CYP17A1_32365;CTSC_32456;CPB2_8369;CHRNA2_32401;CEBPD_8283;CDKN1A_8271;CD36_8243;BMF_8152;BHLHE40_8141;ASS1_33159;AMBP_33085;AHSG_8003;ACOT1_7968;ACADM_7957;ACADL_32776;ACAA2_7955;ABCC2_32541 41.89140079787234 35.164100000000005 1.28141E-12 29.430329135436867 43.73646128656693 27.831461962196013 29.159170172340446 26.53875 1.28141E-12 20.38034877525205 30.74768318309707 19.942193644780406 67.7042440425532 57.57925 1.28142E-12 49.60154310882638 68.50801509228384 42.9297668738716 83.0 87.5421 52.0003;0.348134;0.834827;46.6406;1.38416;108.064;32.2053;45.1539;50.1846;63.2393;104.197;13.3235;2.38018;28.261;29.766;15.797;60.39;77.4407;26.4203;34.1871;36.1411;42.4094;12.4414;63.7758;70.7857;50.0307;18.7324;107.066;56.8931;26.9741;87.2765;30.5572;0.520151;12.9315;46.8463;74.2041;45.2017;2.46923;24.3655;18.9476;16.4324;31.8111;57.1163;27.1247;98.1741;49.0259;49.6814;40.1982;33.1323;42.2579;89.1011;64.9285;1.63089;33.3125;42.3152;45.9204;87.6357;26.4669;105.149;106.367;102.919;46.3784;13.1992;1.28141E-12;59.5777;15.4757;28.5803;32.5155;33.8478;23.3972;60.9984;83.9001;0.750017;62.3934;87.5421;5.72128;17.8395;49.6922;56.2386;25.8316;49.3913;0.306936;6.24967;48.1296;94.8767;57.8085;26.8037;17.2343;12.402;31.2018;11.7137;33.4878;26.5872;46.2316 38.9015;0.118102;0.27095;28.5876;0.540568;83.8836;24.3966;28.132;36.5009;42.7031;80.3101;9.10952;0.56209;22.307;23.347;13.013;43.109;58.7732;21.0125;26.3085;27.0588;26.2988;8.48981;40.9553;46.2356;38.7717;11.6701;61.3361;45.1162;21.799;60.6992;24.2439;0.160202;8.91033;35.8494;49.8682;30.7472;0.871501;19.538;11.6941;10.5224;24.7342;39.6402;21.5108;42.9071;32.6883;33.4626;29.3844;25.6145;23.9469;60.3265;41.6103;0.663137;25.7336;31.4035;34.2198;54.41;21.0456;85.3487;52.7132;89.5012;33.7914;5.6804;1.28141E-12;31.0499;10.2138;22.529;19.6094;26.4736;18.3088;41.6036;42.4185;0.186019;39.0875;53.2453;0.985273;14.6501;35.6654;38.2681;20.4374;41.8524;0.0732342;2.44025;37.5433;73.1342;38.3491;20.9825;14.1233;10.3013;26.858;8.36151;26.6039;21.3695;31.1788 80.8613;1.15962;2.99857;63.7146;4.10872;143.428;46.6068;61.5341;80.9788;121.52;128.412;24.6773;8.82917;38.3264;40.8256;19.9134;104.942;89.8047;35.3561;48.5666;53.6244;81.7305;79.2355;132.567;150.579;73.0083;41.5978;114.259;81.5688;35.2797;197.117;41.2611;2.88499;23.4636;69.127;155.425;78.6415;10.4175;32.1467;45.5481;39.929;44.3296;101.869;36.4819;104.278;89.1623;89.4404;62.3571;46.6629;102.383;106.138;136.455;7.6286;46.9856;64.5991;70.4292;238.963;35.4303;125.652;109.434;115.437;73.6529;32.7581;1.28142E-12;105.243;30.4106;38.8511;49.9875;46.9257;31.9156;113.972;107.32;4.70178;133.304;245.492;22.3625;22.6149;81.6409;102.888;34.8042;62.472;1.73689;19.0606;69.1421;109.848;110.58;36.7081;21.9073;15.4235;37.2719;18.9642;45.3228;35.0407;81.7848 34 60 34 257644;24856;24825;360268;293615;297784;25106;308821;363465;81819;25591;24314;81525;100359982;24539;63868;113965;81869;29328;290556;299626;289388;24360;29496;116636;65210;25146;170945;29184;246142;50559;24158;25287;170465 ZWINT_10214;TTR_10102;TF_10003;SULT1E1_32446;SIRT3_9828;RRS1_9755;RGN_9699;RAB30_9639;PIR_9487;PAX8_9432;PARP1_9425;NQO1_33055;NFKBIB_9308;MPC2_33219;LPL_32544;HSPD1_8849;HADH_8776;GSTM7_8761;GPX4_32827;GNL3_8735;GADD45B_8679;G0S2_32729;FABP1_33091;ERBB3_8571;EIF4EBP1_8550;CYP2J4_32580;CYP17A1_32365;CHRNA2_32401;CD36_8243;BMF_8152;ACOT1_7968;ACADM_7957;ACADL_32776;ACAA2_7955 49.38958176470589 46.743449999999996 23.929172572498114 34.84349411764706 34.9426 15.020697151019226 77.5232255882353 69.78565 47.90398052667078 52.0003;46.6406;45.1539;50.1846;2.38018;60.39;77.4407;26.4203;50.0307;56.8931;26.9741;87.2765;30.5572;46.8463;74.2041;42.2579;33.3125;42.3152;45.9204;87.6357;106.367;46.3784;33.8478;60.9984;83.9001;17.8395;49.6922;49.3913;48.1296;94.8767;31.2018;11.7137;33.4878;26.5872 38.9015;28.5876;28.132;36.5009;0.56209;43.109;58.7732;21.0125;38.7717;45.1162;21.799;60.6992;24.2439;35.8494;49.8682;23.9469;25.7336;31.4035;34.2198;54.41;52.7132;33.7914;26.4736;41.6036;42.4185;14.6501;35.6654;41.8524;37.5433;73.1342;26.858;8.36151;26.6039;21.3695 80.8613;63.7146;61.5341;80.9788;8.82917;104.942;89.8047;35.3561;73.0083;81.5688;35.2797;197.117;41.2611;69.127;155.425;102.383;46.9856;64.5991;70.4292;238.963;109.434;73.6529;46.9257;113.972;107.32;22.6149;81.6409;62.472;69.1421;109.848;37.2719;18.9642;45.3228;35.0407 60 79426;24522;308843;246273;25357;362895;170698;29482;79224;24794;24648;252922;192280;83516;29441;303612;85253;25513;360722;25493;24567;299282;307582;288001;58954;24516;81678;54404;50693;306251;25685;494344;192235;65164;24471;24464;25675;24957;29455;25112;294515;314322;25661;246186;361969;83928;24890;24330;116663;140942;25428;25423;113936;25695;114851;79431;25698;25377;25373;25303 ZFP36_10204;ZFP354A_10203;TSKU_10094;TRIB3_10079;THRSP_33314;STAC3_9953;SLCO1A2_9886;SLC1A2_33059;SERPIND1_9812;SERPINA3C_32925;SERPINA1_9807;PZP_9633;PPP1R3B_9545;PPARGC1A_33189;POR_9531;POLG2_9521;PLG_9501;PIK3R1_32562;PDIA5_9451;NFKBIA_9307;MT1A_9255;LOC299282_9119;LAMA3_8980;KNG1L1_34113;KLF6_8969;JUN_8938;ITPR2_8931;ITIH4_32725;ITIH3_32422;ITIH1_33132;IGFBP1_32306;IER2_32643;HYOU1_8857;HTRA1_8856;HSPB1_8847;HP_8823;HMGCR_8810;GLUL_32832;GDF15_33113;GADD45A_8678;FOXO3_8662;FOS_8657;FN1_8655;FGL1_8640;FGA_8632;FETUB_33027;ESR1_33192;EGR1_8533;DUSP6_8506;DDIT4_8450;CYP7A1_8430;CTSC_32456;CPB2_8369;CEBPD_8283;CDKN1A_8271;BHLHE40_8141;ASS1_33159;AMBP_33085;AHSG_8003;ABCC2_32541 37.64243158333334 29.17315 31.531702024721863 25.93805327000002 22.418 22.346166784874935 62.14015450000001 44.93885 50.07544048866332 0.348134;0.834827;1.38416;108.064;32.2053;63.2393;104.197;13.3235;28.261;29.766;15.797;34.1871;36.1411;42.4094;12.4414;63.7758;70.7857;18.7324;107.066;0.520151;12.9315;45.2017;2.46923;24.3655;18.9476;16.4324;31.8111;57.1163;27.1247;98.1741;49.0259;49.6814;40.1982;33.1323;89.1011;64.9285;1.63089;26.4669;105.149;102.919;13.1992;1.28141E-12;59.5777;15.4757;28.5803;32.5155;23.3972;0.750017;62.3934;87.5421;5.72128;56.2386;25.8316;0.306936;6.24967;57.8085;26.8037;17.2343;12.402;46.2316 0.118102;0.27095;0.540568;83.8836;24.3966;42.7031;80.3101;9.10952;22.307;23.347;13.013;26.3085;27.0588;26.2988;8.48981;40.9553;46.2356;11.6701;61.3361;0.160202;8.91033;30.7472;0.871501;19.538;11.6941;10.5224;24.7342;39.6402;21.5108;42.9071;32.6883;33.4626;29.3844;25.6145;60.3265;41.6103;0.663137;21.0456;85.3487;89.5012;5.6804;1.28141E-12;31.0499;10.2138;22.529;19.6094;18.3088;0.186019;39.0875;53.2453;0.985273;38.2681;20.4374;0.0732342;2.44025;38.3491;20.9825;14.1233;10.3013;31.1788 1.15962;2.99857;4.10872;143.428;46.6068;121.52;128.412;24.6773;38.3264;40.8256;19.9134;48.5666;53.6244;81.7305;79.2355;132.567;150.579;41.5978;114.259;2.88499;23.4636;78.6415;10.4175;32.1467;45.5481;39.929;44.3296;101.869;36.4819;104.278;89.1623;89.4404;62.3571;46.6629;106.138;136.455;7.6286;35.4303;125.652;115.437;32.7581;1.28142E-12;105.243;30.4106;38.8511;49.9875;31.9156;4.70178;133.304;245.492;22.3625;102.888;34.8042;1.73689;19.0606;110.58;36.7081;21.9073;15.4235;81.7848 0 Exp 2,37(0.4);Exp 3,4(0.05);Exp 4,5(0.06);Hill,8(0.09);Linear,20(0.22);Poly 2,18(0.2);Power,2(0.03) 2.035535726329908 530.6626681089401 1.511321783065796 344.14306640625 35.29508008368994 1.751175343990326 35.941807713955335 47.840993881789394 25.039108124680407 33.279232220000466 57.6768673022589 77.73162078284756 DOWN 0.3617021276595745 0.6382978723404256 0.0 GO:0009057 5 macromolecule catabolic process 126 135 6 6 5 5 5 5 157 130 2255 0.12789 0.94049 0.27374 3.7 79426;312688;29676;308441;25377 zfp36;usp18;psmb3;exosc5;ambp ZFP36_10204;USP18_10138;PSMB3_9589;EXOSC5_32543;AMBP_33085 38.437426800000004 23.7888 0.348134 42.10031530640585 42.45045907330276 45.71151670098092 27.6777604 19.2724 0.118102 27.826698563849448 30.260530283587705 29.95264351960534 50.849844000000004 30.901 1.15962 53.50799455689477 55.00653874295166 57.78700904642561 0.348134;108.883;23.7888;41.9329;17.2343 0.118102;73.1414;19.2724;31.7336;14.1233 1.15962;138.144;30.901;62.1373;21.9073 3 2 3 312688;29676;308441 USP18_10138;PSMB3_9589;EXOSC5_32543 58.20156666666666 41.9329 44.81916838522703 41.382466666666666 31.7336 28.200935466989982 77.06076666666667 62.1373 55.15702725186822 108.883;23.7888;41.9329 73.1414;19.2724;31.7336 138.144;30.901;62.1373 2 79426;25377 ZFP36_10204;AMBP_33085 8.791217000000001 8.791217000000001 11.940322486841717 7.120701 7.120701 9.903170477660273 11.53346 11.53346 14.670825221888506 0.348134;17.2343 0.118102;14.1233 1.15962;21.9073 0 Exp 2,3(0.6);Hill,1(0.2);Power,1(0.2) 1.698172134363436 8.511896133422852 1.5979743003845215 1.9381765127182007 0.13751563487087617 1.6425341367721558 1.534873375475037 75.33998022452496 3.2865836853600534 52.06893711463995 3.9480188377890713 97.75166916221093 UP 0.6 0.4 0.0 GO:0006690 6 icosanoid metabolic process 39 48 12 12 8 9 5 5 157 43 2342 0.91931 0.18658 0.22796 10.42 29328;25315;65210;24894;50681 gpx4;ephx1;cyp2j4;cyp2a1;acox1 GPX4_32827;EPHX1_8567;CYP2J4_32580;CYP2A1_32717;ACOX1_7973 30.963780000000003 23.1906 12.4747 18.67509441146148 26.041915111211303 17.36431971500792 22.180030000000002 16.2815 7.00435 13.611834745709329 18.636441848887888 12.853267908242596 49.40778 33.4539 22.6149 32.89155153997754 41.12633178914938 29.810004922973597 1.5 20.515050000000002 3.5 50.65705 45.9204;12.4747;17.8395;55.3937;23.1906 34.2198;7.00435;14.6501;38.7444;16.2815 70.4292;23.684;22.6149;96.8569;33.4539 5 0 5 29328;25315;65210;24894;50681 GPX4_32827;EPHX1_8567;CYP2J4_32580;CYP2A1_32717;ACOX1_7973 30.963780000000003 23.1906 18.67509441146148 22.180030000000002 16.2815 13.611834745709329 49.40778 33.4539 32.89155153997754 45.9204;12.4747;17.8395;55.3937;23.1906 34.2198;7.00435;14.6501;38.7444;16.2815 70.4292;23.684;22.6149;96.8569;33.4539 0 0 Exp 2,1(0.2);Hill,1(0.2);Linear,2(0.4);Power,1(0.2) 2.7019477966518863 15.447120666503906 1.547789216041565 5.973292827606201 1.8460440268220215 2.4453113079071045 14.594338008620312 47.33322199137969 10.248730786359342 34.11132921364066 20.577063909499536 78.23849609050046 UP 1.0 0.0 0.0 GO:0051128 5 regulation of cellular component organization 515 547 23 23 18 21 17 17 145 530 1855 1.2761E-4 0.99995 2.2886E-4 3.11 24825;83516;25513;25591;25685;24471;290556;29455;25661;24890;116636;113936;114851;29184;246142;25373;170465 tf;ppargc1a;pik3r1;parp1;igfbp1;hspb1;gnl3;gdf15;fn1;esr1;eif4ebp1;cpb2;cdkn1a;cd36;bmf;ahsg;acaa2 TF_10003;PPARGC1A_33189;PIK3R1_32562;PARP1_9425;IGFBP1_32306;HSPB1_8847;GNL3_8735;GDF15_33113;FN1_8655;ESR1_33192;EIF4EBP1_8550;CPB2_8369;CDKN1A_8271;CD36_8243;BMF_8152;AHSG_8003;ACAA2_7955 49.71372176470588 45.1539 6.24967 31.62407406596363 52.82551796906987 32.35023265763143 33.98097352941176 28.132 2.44025 22.721459105546824 36.34947113626691 24.341690312762626 76.93265294117647 69.1421 15.4235 55.01783059276235 74.34349142631292 41.67788790481102 45.1539;42.4094;18.7324;26.9741;49.0259;89.1011;87.6357;105.149;59.5777;23.3972;83.9001;25.8316;6.24967;48.1296;94.8767;12.402;26.5872 28.132;26.2988;11.6701;21.799;32.6883;60.3265;54.41;85.3487;31.0499;18.3088;42.4185;20.4374;2.44025;37.5433;73.1342;10.3013;21.3695 61.5341;81.7305;41.5978;35.2797;89.1623;106.138;238.963;125.652;105.243;31.9156;107.32;34.8042;19.0606;69.1421;109.848;15.4235;35.0407 7 10 7 24825;25591;290556;116636;29184;246142;170465 TF_10003;PARP1_9425;GNL3_8735;EIF4EBP1_8550;CD36_8243;BMF_8152;ACAA2_7955 59.03675714285714 48.1296 29.192677151976383 39.8295 37.5433 18.869842298758087 93.87537142857143 69.1421 70.75658590175462 45.1539;26.9741;87.6357;83.9001;48.1296;94.8767;26.5872 28.132;21.799;54.41;42.4185;37.5433;73.1342;21.3695 61.5341;35.2797;238.963;107.32;69.1421;109.848;35.0407 10 83516;25513;25685;24471;29455;25661;24890;113936;114851;25373 PPARGC1A_33189;PIK3R1_32562;IGFBP1_32306;HSPB1_8847;GDF15_33113;FN1_8655;ESR1_33192;CPB2_8369;CDKN1A_8271;AHSG_8003 43.187597 34.1205 33.08860597378367 29.887005 23.3681 25.203101562974016 65.07275000000001 61.66415000000001 40.792778899872566 42.4094;18.7324;49.0259;89.1011;105.149;59.5777;23.3972;25.8316;6.24967;12.402 26.2988;11.6701;32.6883;60.3265;85.3487;31.0499;18.3088;20.4374;2.44025;10.3013 81.7305;41.5978;89.1623;106.138;125.652;105.243;31.9156;34.8042;19.0606;15.4235 0 Exp 2,9(0.53);Exp 3,1(0.06);Exp 4,1(0.06);Poly 2,5(0.3);Power,1(0.06) 1.9928808480891764 35.48149371147156 1.522104263305664 3.9562058448791504 0.7260282248681132 1.7576230764389038 34.68059120792968 64.74685232148208 23.17987748904526 44.78206956977828 50.778836436497414 103.08646944585553 CONFLICT 0.4117647058823529 0.5882352941176471 0.0 GO:0009150 7 purine ribonucleotide metabolic process 68 80 23 23 15 20 13 13 149 67 2318 0.99962 0.0012827 0.0012827 16.25 360268;298490;24651;294103;100359982;25675;83842;25028;192272;170570;50559;170465;296925 sult1e1;ppcs;pklr;papss2;mpc2;hmgcr;crot;ampd1;acot2;acot12;acot1;acaa2;aass SULT1E1_32446;PPCS_9540;PKLR_9489;PAPSS2_33237;MPC2_33219;HMGCR_8810;CROT_8384;AMPD1_32743;ACOT2_7969;ACOT12_32718;ACOT1_7968;ACAA2_7955;AASS_7936 28.385372307692304 27.4644 1.63089 17.242256948174916 32.67459349596367 14.73354806140104 22.305335923076925 21.7498 0.663137 13.591066221377098 26.01469155213533 11.733001150494477 40.098984615384616 37.0295 7.6286 25.12052809914122 45.00688869344718 22.04134654243901 3.0 20.3353 7.0 30.3423 50.1846;20.3353;23.0963;34.4443;46.8463;1.63089;7.4229;60.9045;8.54905;30.3423;31.2018;26.5872;27.4644 36.5009;16.7643;17.4625;25.719;35.8494;0.663137;5.75707;50.0633;7.19676;24.0157;26.858;21.3695;21.7498 80.9788;25.6711;32.9443;51.1014;69.127;7.6286;10.316;82.6625;10.4125;41.1025;37.2719;35.0407;37.0295 10 3 10 360268;298490;100359982;83842;25028;192272;170570;50559;170465;296925 SULT1E1_32446;PPCS_9540;MPC2_33219;CROT_8384;AMPD1_32743;ACOT2_7969;ACOT12_32718;ACOT1_7968;ACAA2_7955;AASS_7936 30.983834999999992 28.903350000000003 17.38306263183362 24.612473 22.88275 13.580562993792142 42.96125000000001 37.1507 26.381805639335344 50.1846;20.3353;46.8463;7.4229;60.9045;8.54905;30.3423;31.2018;26.5872;27.4644 36.5009;16.7643;35.8494;5.75707;50.0633;7.19676;24.0157;26.858;21.3695;21.7498 80.9788;25.6711;69.127;10.316;82.6625;10.4125;41.1025;37.2719;35.0407;37.0295 3 24651;294103;25675 PKLR_9489;PAPSS2_33237;HMGCR_8810 19.72383 23.0963 16.664637241257306 14.614879 17.4625 12.768350586055469 30.558099999999996 32.9443 21.834412009257317 23.0963;34.4443;1.63089 17.4625;25.719;0.663137 32.9443;51.1014;7.6286 0 Exp 2,9(0.7);Exp 4,1(0.08);Linear,2(0.16);Poly 2,1(0.08) 3.720852836162964 382.4242297410965 1.571676254272461 344.14306640625 94.6061467095719 1.9288111925125122 19.01237466142424 37.75836995396038 14.91714816516712 29.69352368098673 26.443309986827096 53.754659243942136 UP 0.7692307692307693 0.23076923076923078 0.0 GO:2000351 9 regulation of endothelial cell apoptotic process 25 28 2 2 2 2 2 2 160 26 2359 0.73822 0.5404 0.6976 7.14 294515;361969 foxo3;fga FOXO3_8662;FGA_8632 20.88975 20.88975 13.1992 10.876080112108406 26.101155796306458 7.998225919380282 14.1047 14.1047 5.6804 11.913759313499664 19.81332238069117 8.761331063790703 35.8046 35.8046 32.7581 4.3084016177696 37.86902292923753 3.168381359381466 0.5 20.88975 13.1992;28.5803 5.6804;22.529 32.7581;38.8511 0 2 0 2 294515;361969 FOXO3_8662;FGA_8632 20.88975 20.88975 10.876080112108406 14.1047 14.1047 11.913759313499664 35.8046 35.8046 4.3084016177696 13.1992;28.5803 5.6804;22.529 32.7581;38.8511 0 Exp 4,1(0.5);Linear,1(0.5) 1.7509469666418858 3.5302371978759766 1.541895866394043 1.9883413314819336 0.3156846157936295 1.7651185989379883 5.816271999999998 35.963228 -2.4069280000000006 30.616328000000003 29.83346 41.775740000000006 DOWN 0.0 1.0 0.0 GO:0048871 4 multicellular organismal homeostasis 34 36 7 7 6 6 5 5 157 31 2354 0.97612 0.07456 0.07456 13.89 246074;83516;24330;29184;25287 scd;ppargc1a;egr1;cd36;acadl SCD1_9787;PPARGC1A_33189;EGR1_8533;CD36_8243;ACADL_32776 46.047363399999995 42.4094 0.750017 37.937527918941925 42.63570979319843 35.050631323816354 30.877043800000003 26.6039 0.186019 22.947983003484033 29.223624709427447 22.058633815738485 124.719236 69.1421 4.70178 169.14252349464783 104.32559823937713 147.73747434570453 0.5 17.1189085 2.5 45.2695 105.46;42.4094;0.750017;48.1296;33.4878 63.7532;26.2988;0.186019;37.5433;26.6039 422.699;81.7305;4.70178;69.1421;45.3228 3 2 3 246074;29184;25287 SCD1_9787;CD36_8243;ACADL_32776 62.35913333333334 48.1296 38.03760123053676 42.63346666666666 37.5433 19.090572808151506 179.05463333333333 69.1421 211.3380534106987 105.46;48.1296;33.4878 63.7532;37.5433;26.6039 422.699;69.1421;45.3228 2 83516;24330 PPARGC1A_33189;EGR1_8533 21.5797085 21.5797085 29.457632219347577 13.2424095 13.2424095 18.464524520739236 43.21614 43.21614 54.467530258119844 42.4094;0.750017 26.2988;0.186019 81.7305;4.70178 0 Exp 2,4(0.8);Hill,1(0.2) 2.4233479641981246 12.770267486572266 1.7576230764389038 4.21828556060791 0.9953366298058768 2.2368218898773193 12.793654000580297 79.3010727994197 10.762249822618362 50.99183777738163 -23.54072272459598 272.979194724596 UP 0.6 0.4 0.0 GO:0010634 6 positive regulation of epithelial cell migration 44 46 4 4 4 3 3 3 159 43 2342 0.66479 0.56884 1.0 6.52 85253;24516;24471 plg;jun;hspb1 PLG_9501;JUN_8938;HSPB1_8847 58.77306666666667 70.7857 16.4324 37.79434494237639 67.14641438782192 32.10337550653435 39.028166666666664 46.2356 10.5224 25.67240572372083 44.62089840680925 21.90985278347531 98.882 106.138 39.929 55.680721771543155 112.31322795722393 49.88329073058907 1.5 79.9434 70.7857;16.4324;89.1011 46.2356;10.5224;60.3265 150.579;39.929;106.138 0 3 0 3 85253;24516;24471 PLG_9501;JUN_8938;HSPB1_8847 58.77306666666667 70.7857 37.79434494237639 39.028166666666664 46.2356 25.67240572372083 98.882 106.138 55.680721771543155 70.7857;16.4324;89.1011 46.2356;10.5224;60.3265 150.579;39.929;106.138 0 Linear,1(0.34);Poly 2,2(0.67) 1.7238571958983984 5.201292514801025 1.5254690647125244 1.9785058498382568 0.22870690105820612 1.6973176002502441 16.00473922306655 101.5413941102668 9.977104770209078 68.07922856312425 35.873331781192725 161.8906682188073 DOWN 0.0 1.0 0.0 GO:0032868 6 response to insulin 96 102 19 18 14 15 11 11 151 91 2294 0.97394 0.05599 0.092189 10.78 246273;24651;25513;25591;113965;361969;29496;24330;29184;25373;312382 trib3;pklr;pik3r1;parp1;hadh;fga;erbb3;egr1;cd36;ahsg;abcg2 TRIB3_10079;PKLR_9489;PIK3R1_32562;PARP1_9425;HADH_8776;FGA_8632;ERBB3_8571;EGR1_8533;CD36_8243;AHSG_8003;ABCG2_32656 33.29601427272728 26.9741 0.750017 30.397871046251986 31.9386504746011 26.915766306577076 25.04051809090909 21.799 0.186019 23.407774755961235 24.109094518900495 20.628115251435673 50.33744363636363 38.8511 4.70178 43.169949237326485 48.12229907252684 39.38243820214831 4.5 25.0352 9.5 84.5312 108.064;23.0963;18.7324;26.9741;33.3125;28.5803;60.9984;0.750017;48.1296;12.402;5.21654 83.8836;17.4625;11.6701;21.799;25.7336;22.529;41.6036;0.186019;37.5433;10.3013;2.73368 143.428;32.9443;41.5978;35.2797;46.9856;38.8511;113.972;4.70178;69.1421;15.4235;11.386 5 6 5 25591;113965;29496;29184;312382 PARP1_9425;HADH_8776;ERBB3_8571;CD36_8243;ABCG2_32656 34.926228 33.3125 21.228478535988383 25.882636 25.7336 15.294543574506564 55.35308 46.9856 38.83418044850438 26.9741;33.3125;60.9984;48.1296;5.21654 21.799;25.7336;41.6036;37.5433;2.73368 35.2797;46.9856;113.972;69.1421;11.386 6 246273;24651;25513;361969;24330;25373 TRIB3_10079;PKLR_9489;PIK3R1_32562;FGA_8632;EGR1_8533;AHSG_8003 31.93750283333333 20.91435 38.505457103286645 24.338753166666663 14.566299999999998 30.123234490110132 46.15774666666667 35.8977 49.74629362252696 108.064;23.0963;18.7324;28.5803;0.750017;12.402 83.8836;17.4625;11.6701;22.529;0.186019;10.3013 143.428;32.9443;41.5978;38.8511;4.70178;15.4235 0 Exp 2,4(0.37);Exp 4,1(0.1);Hill,1(0.1);Linear,3(0.28);Poly 2,2(0.19) 2.140855202884878 24.99096167087555 1.5074360370635986 4.21828556060791 0.8866946716761045 1.87713623046875 15.33202044867173 51.26000809678281 11.207407196032213 38.87362898578596 24.825633934159423 75.84925333856785 CONFLICT 0.45454545454545453 0.5454545454545454 0.0 GO:0099537 5 trans-synaptic signaling 45 45 3 3 3 3 3 3 159 42 2343 0.67961 0.55361 0.76174 6.67 362895;85253;170945 stac3;plg;chrna2 STAC3_9953;PLG_9501;CHRNA2_32401 61.13876666666667 63.2393 49.3913 10.850772693837662 60.45480425677839 11.537800816870648 43.597033333333336 42.7031 41.8524 2.3243167089131362 43.63340817063691 2.4186282203623812 111.52366666666667 121.52 62.472 44.89605631158854 108.5275758310091 47.70545508873688 1.5 67.0125 63.2393;70.7857;49.3913 42.7031;46.2356;41.8524 121.52;150.579;62.472 1 2 1 170945 CHRNA2_32401 49.3913 49.3913 41.8524 41.8524 62.472 62.472 49.3913 41.8524 62.472 2 362895;85253 STAC3_9953;PLG_9501 67.0125 67.0125 5.336110613546067 44.46935 44.46935 2.4978547045414903 136.0495 136.0495 20.54781595450004 63.2393;70.7857 42.7031;46.2356 121.52;150.579 0 Exp 2,1(0.34);Linear,2(0.67) 2.2281367119525117 6.923211097717285 1.5254690647125244 2.879150867462158 0.7010408011070594 2.5185911655426025 48.859961456689526 73.41757187664382 40.96682137329024 46.227245293376434 60.718996280452075 162.32833705288127 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0043067 6 regulation of programmed cell death 435 463 43 43 37 38 32 32 130 431 1954 0.74335 0.32725 0.59869 6.91 79426;24794;25106;83516;29441;25513;81819;25591;24314;24567;24516;192235;63868;24471;25675;29328;299626;25112;289388;294515;25661;361969;24360;24890;29496;24330;116663;25423;114851;246142;50559;170465 zfp36;serpina3c;rgn;ppargc1a;por;pik3r1;pax8;parp1;nqo1;mt1;jun;hyou1;hspd1;hspb1;hmgcr;gpx4;gadd45b;gadd45a;g0s2;foxo3;fn1;fga;fabp1;esr1;erbb3;egr1;dusp6;ctsc;cdkn1a;bmf;acot1;acaa2 ZFP36_10204;SERPINA3C_32925;RGN_9699;PPARGC1A_33189;POR_9531;PIK3R1_32562;PAX8_9432;PARP1_9425;NQO1_33055;MT1A_9255;JUN_8938;HYOU1_8857;HSPD1_8849;HSPB1_8847;HMGCR_8810;GPX4_32827;GADD45B_8679;GADD45A_8678;G0S2_32729;FOXO3_8662;FN1_8655;FGA_8632;FABP1_33091;ESR1_33192;ERBB3_8571;EGR1_8533;DUSP6_8506;CTSC_32456;CDKN1A_8271;BMF_8152;ACOT1_7968;ACAA2_7955 42.32239096875001 37.022999999999996 0.348134 30.65384477158211 45.58512691532666 29.911740406962604 29.602485875000003 26.386200000000002 0.118102 22.155593739761873 32.80371547023497 23.17973005570331 67.842253125 66.39314999999999 1.15962 44.25430501751923 70.2478829187159 38.72012284417968 22.5 58.2354 0.348134;29.766;77.4407;42.4094;12.4414;18.7324;56.8931;26.9741;87.2765;12.9315;16.4324;40.1982;42.2579;89.1011;1.63089;45.9204;106.367;102.919;46.3784;13.1992;59.5777;28.5803;33.8478;23.3972;60.9984;0.750017;62.3934;56.2386;6.24967;94.8767;31.2018;26.5872 0.118102;23.347;58.7732;26.2988;8.48981;11.6701;45.1162;21.799;60.6992;8.91033;10.5224;29.3844;23.9469;60.3265;0.663137;34.2198;52.7132;89.5012;33.7914;5.6804;31.0499;22.529;26.4736;18.3088;41.6036;0.186019;39.0875;38.2681;2.44025;73.1342;26.858;21.3695 1.15962;40.8256;89.8047;81.7305;79.2355;41.5978;81.5688;35.2797;197.117;23.4636;39.929;62.3571;102.383;106.138;7.6286;70.4292;109.434;115.437;73.6529;32.7581;105.243;38.8511;46.9257;31.9156;113.972;4.70178;133.304;102.888;19.0606;109.848;37.2719;35.0407 13 19 13 25106;81819;25591;24314;63868;29328;299626;289388;24360;29496;246142;50559;170465 RGN_9699;PAX8_9432;PARP1_9425;NQO1_33055;HSPD1_8849;GPX4_32827;GADD45B_8679;G0S2_32729;FABP1_33091;ERBB3_8571;BMF_8152;ACOT1_7968;ACAA2_7955 56.69384615384615 46.3784 26.928893863209947 40.03829230769231 34.2198 16.91356850300283 84.8252 81.5688 44.7189373678721 77.4407;56.8931;26.9741;87.2765;42.2579;45.9204;106.367;46.3784;33.8478;60.9984;94.8767;31.2018;26.5872 58.7732;45.1162;21.799;60.6992;23.9469;34.2198;52.7132;33.7914;26.4736;41.6036;73.1342;26.858;21.3695 89.8047;81.5688;35.2797;197.117;102.383;70.4292;109.434;73.6529;46.9257;113.972;109.848;37.2719;35.0407 19 79426;24794;83516;29441;25513;24567;24516;192235;24471;25675;25112;294515;25661;361969;24890;24330;116663;25423;114851 ZFP36_10204;SERPINA3C_32925;PPARGC1A_33189;POR_9531;PIK3R1_32562;MT1A_9255;JUN_8938;HYOU1_8857;HSPB1_8847;HMGCR_8810;GADD45A_8678;FOXO3_8662;FN1_8655;FGA_8632;ESR1_33192;EGR1_8533;DUSP6_8506;CTSC_32456;CDKN1A_8271 32.48929005263158 23.3972 29.725885902737996 22.462197263157893 18.3088 22.851799496705937 56.22234210526316 40.8256 41.09572698053704 0.348134;29.766;42.4094;12.4414;18.7324;12.9315;16.4324;40.1982;89.1011;1.63089;102.919;13.1992;59.5777;28.5803;23.3972;0.750017;62.3934;56.2386;6.24967 0.118102;23.347;26.2988;8.48981;11.6701;8.91033;10.5224;29.3844;60.3265;0.663137;89.5012;5.6804;31.0499;22.529;18.3088;0.186019;39.0875;38.2681;2.44025 1.15962;40.8256;81.7305;79.2355;41.5978;23.4636;39.929;62.3571;106.138;7.6286;115.437;32.7581;105.243;38.8511;31.9156;4.70178;133.304;102.888;19.0606 0 Exp 2,12(0.38);Exp 3,1(0.04);Exp 4,3(0.1);Hill,2(0.07);Linear,4(0.13);Poly 2,8(0.25);Power,2(0.07) 2.194298889402511 403.45401179790497 1.522104263305664 344.14306640625 60.50046454986936 1.7549105286598206 31.7013756301115 52.9434063073885 21.925964293446075 37.27900745655393 52.508918729453015 83.17558752054701 CONFLICT 0.40625 0.59375 0.0 GO:0050900 5 leukocyte migration 64 68 4 4 3 3 3 3 159 65 2320 0.36173 0.81894 0.79887 4.41 29573;85253;25493 slc37a4;plg;nfkbia SLC37A4_9871;PLG_9501;NFKBIA_9307 37.007483666666666 39.7166 0.520151 35.211025653174325 51.162680413298574 25.5679167805731 23.02896733333333 22.6911 0.160202 23.03955709135489 31.915101332701195 17.8200001279632 71.16579666666667 60.0334 2.88499 74.47367212060941 97.76851745051559 62.92944219361609 39.7166;70.7857;0.520151 22.6911;46.2356;0.160202 60.0334;150.579;2.88499 0 3 0 3 29573;85253;25493 SLC37A4_9871;PLG_9501;NFKBIA_9307 37.007483666666666 39.7166 35.211025653174325 23.02896733333333 22.6911 23.03955709135489 71.16579666666667 60.0334 74.47367212060941 39.7166;70.7857;0.520151 22.6911;46.2356;0.160202 60.0334;150.579;2.88499 0 Exp 4,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 1.749765969977143 5.273660182952881 1.5254690647125244 1.893584966659546 0.20222095475137797 1.8546061515808105 -2.8375428063672317 76.85251013970057 -3.042745864525518 49.10068053119218 -13.109096840225902 155.44069017355923 DOWN 0.0 1.0 0.0 GO:0051341 5 regulation of oxidoreductase activity 32 35 6 6 5 6 5 5 157 30 2355 0.97903 0.067521 0.067521 14.29 293615;25106;29441;24464;24890 sirt3;rgn;por;hp;esr1 SIRT3_9828;RGN_9699;POR_9531;HP_8823;ESR1_33192 36.117596000000006 23.3972 2.38018 33.15965577051547 39.96444522365078 34.344875063666926 25.548840000000002 18.3088 0.56209 24.1329388701739 27.594056756486257 24.734946494962823 69.24799399999999 79.2355 8.82917 50.20769868373954 81.56985672992532 51.51420345248198 0.5 7.41079 2.5 44.16285 2.38018;77.4407;12.4414;64.9285;23.3972 0.56209;58.7732;8.48981;41.6103;18.3088 8.82917;89.8047;79.2355;136.455;31.9156 2 3 2 293615;25106 SIRT3_9828;RGN_9699 39.91044 39.91044 53.075802691388475 29.667645 29.667645 41.161470621396056 49.316935 49.316935 57.25834637317472 2.38018;77.4407 0.56209;58.7732 8.82917;89.8047 3 29441;24464;24890 POR_9531;HP_8823;ESR1_33192 33.58903333333333 23.3972 27.68806632149188 22.802970000000002 18.3088 17.01146341299595 82.53536666666668 79.2355 52.34776383097307 12.4414;64.9285;23.3972 8.48981;41.6103;18.3088 79.2355;136.455;31.9156 0 Exp 2,2(0.4);Hill,1(0.2);Poly 2,2(0.4) 1.8320730220429569 9.29339611530304 1.5209722518920898 2.436986207962036 0.3652358709010764 1.7198865413665771 7.051876189960623 65.18331581003939 4.39538641026213 46.70229358973788 25.239005717738017 113.25698228226196 DOWN 0.4 0.6 0.0 GO:0042886 6 amide transport 189 201 16 15 13 14 12 12 150 189 2196 0.48067 0.63848 1.0 5.97 171139;297784;308821;25513;25493;63868;24471;85255;114851;29184;65054;312382 timm9;rrs1;rab30;pik3r1;nfkbia;hspd1;hspb1;hacl1;cdkn1a;cd36;aqp9;abcg2 TIMM9_10020;RRS1_9755;RAB30_9639;PIK3R1_32562;NFKBIA_9307;HSPD1_8849;HSPB1_8847;HACL1_8775;CDKN1A_8271;CD36_8243;AQP9_32709;ABCG2_32656 171139(0.04986) 31.741321749999997 27.07595 0.520151 25.720484047030453 33.41576433745624 27.93244971825483 22.135386 21.47485 0.160202 18.270351709576193 22.989696019567425 19.912935811377835 51.95624916666667 39.6256 2.88499 36.34088418591516 54.433113485488036 37.67975128721 9.5 54.2598 38.5191;60.39;26.4203;18.7324;0.520151;42.2579;89.1011;17.6275;6.24967;48.1296;27.7316;5.21654 29.55;43.109;21.0125;11.6701;0.160202;23.9469;60.3265;11.195;2.44025;37.5433;21.9372;2.73368 55.4685;104.942;35.3561;41.5978;2.88499;102.383;106.138;37.6534;19.0606;69.1421;37.4625;11.386 7 5 7 171139;297784;308821;63868;85255;29184;312382 TIMM9_10020;RRS1_9755;RAB30_9639;HSPD1_8849;HACL1_8775;CD36_8243;ABCG2_32656 34.08013428571429 38.5191 18.879645568554206 24.155768571428574 23.9469 14.167803147497763 59.47587142857143 55.4685 35.09108361847846 38.5191;60.39;26.4203;42.2579;17.6275;48.1296;5.21654 29.55;43.109;21.0125;23.9469;11.195;37.5433;2.73368 55.4685;104.942;35.3561;102.383;37.6534;69.1421;11.386 5 25513;25493;24471;114851;65054 PIK3R1_32562;NFKBIA_9307;HSPB1_8847;CDKN1A_8271;AQP9_32709 28.466984200000002 18.7324 35.51912672943429 19.306850400000002 11.6701 24.489419669539963 41.428778 37.4625 39.33510620896962 18.7324;0.520151;89.1011;6.24967;27.7316 11.6701;0.160202;60.3265;2.44025;21.9372 41.5978;2.88499;106.138;19.0606;37.4625 0 Exp 2,3(0.25);Exp 3,1(0.09);Exp 4,3(0.25);Linear,2(0.17);Poly 2,3(0.25) 1.9175579425338434 23.56016993522644 1.5074360370635986 2.945132255554199 0.46870320607333954 1.7675827741622925 17.188587929524306 46.29405557047569 11.797961371841302 32.4728106281587 31.394458284686078 72.51804004864726 CONFLICT 0.5833333333333334 0.4166666666666667 0.0 GO:0032268 6 regulation of cellular protein metabolic process 600 637 56 56 48 52 44 44 118 593 1792 0.77424 0.28479 0.51237 6.91 79426;246273;24825;293615;79224;24794;24648;25106;252922;192280;83516;29441;25513;25493;299282;288001;24516;54404;50693;306251;63868;24471;25675;290556;29455;299626;25112;294515;25661;361969;83928;24360;24890;29496;116636;24330;116663;140942;25423;113936;114851;29184;25377;25373 zfp36;trib3;tf;sirt3;serpind1;serpina3c;serpina1;rgn;pzp;ppp1r3b;ppargc1a;por;pik3r1;nfkbia;loc299282;kng1;jun;itih4;itih3;itih1;hspd1;hspb1;hmgcr;gnl3;gdf15;gadd45b;gadd45a;foxo3;fn1;fga;fetub;fabp1;esr1;erbb3;eif4ebp1;egr1;dusp6;ddit4;ctsc;cpb2;cdkn1a;cd36;ambp;ahsg ZFP36_10204;TRIB3_10079;TF_10003;SIRT3_9828;SERPIND1_9812;SERPINA3C_32925;SERPINA1_9807;RGN_9699;PZP_9633;PPP1R3B_9545;PPARGC1A_33189;POR_9531;PIK3R1_32562;NFKBIA_9307;LOC299282_9119;KNG1L1_34113;JUN_8938;ITIH4_32725;ITIH3_32422;ITIH1_33132;HSPD1_8849;HSPB1_8847;HMGCR_8810;GNL3_8735;GDF15_33113;GADD45B_8679;GADD45A_8678;FOXO3_8662;FN1_8655;FGA_8632;FETUB_33027;FABP1_33091;ESR1_33192;ERBB3_8571;EIF4EBP1_8550;EGR1_8533;DUSP6_8506;DDIT4_8450;CTSC_32456;CPB2_8369;CDKN1A_8271;CD36_8243;AMBP_33085;AHSG_8003 43.36148277272728 34.01745 0.348134 33.012037358366996 48.22824682453899 31.681367476197114 29.209163863636363 25.12285 0.118102 22.752427222012315 32.61500950045837 23.15296554674664 70.09406727272727 51.805949999999996 1.15962 55.149185122876204 74.24011168555671 43.42545110331978 30.5 58.347 0.348134;108.064;45.1539;2.38018;28.261;29.766;15.797;77.4407;34.1871;36.1411;42.4094;12.4414;18.7324;0.520151;45.2017;24.3655;16.4324;57.1163;27.1247;98.1741;42.2579;89.1011;1.63089;87.6357;105.149;106.367;102.919;13.1992;59.5777;28.5803;32.5155;33.8478;23.3972;60.9984;83.9001;0.750017;62.3934;87.5421;56.2386;25.8316;6.24967;48.1296;17.2343;12.402 0.118102;83.8836;28.132;0.56209;22.307;23.347;13.013;58.7732;26.3085;27.0588;26.2988;8.48981;11.6701;0.160202;30.7472;19.538;10.5224;39.6402;21.5108;42.9071;23.9469;60.3265;0.663137;54.41;85.3487;52.7132;89.5012;5.6804;31.0499;22.529;19.6094;26.4736;18.3088;41.6036;42.4185;0.186019;39.0875;53.2453;38.2681;20.4374;2.44025;37.5433;14.1233;10.3013 1.15962;143.428;61.5341;8.82917;38.3264;40.8256;19.9134;89.8047;48.5666;53.6244;81.7305;79.2355;41.5978;2.88499;78.6415;32.1467;39.929;101.869;36.4819;104.278;102.383;106.138;7.6286;238.963;125.652;109.434;115.437;32.7581;105.243;38.8511;49.9875;46.9257;31.9156;113.972;107.32;4.70178;133.304;245.492;102.888;34.8042;19.0606;69.1421;21.9073;15.4235 10 34 10 24825;293615;25106;63868;290556;299626;24360;29496;116636;29184 TF_10003;SIRT3_9828;RGN_9699;HSPD1_8849;GNL3_8735;GADD45B_8679;FABP1_33091;ERBB3_8571;EIF4EBP1_8550;CD36_8243 58.811128 54.564 30.652102432293944 36.657638999999996 39.57345 17.516064238847513 94.83077699999998 96.09385 60.60048229955822 45.1539;2.38018;77.4407;42.2579;87.6357;106.367;33.8478;60.9984;83.9001;48.1296 28.132;0.56209;58.7732;23.9469;54.41;52.7132;26.4736;41.6036;42.4185;37.5433 61.5341;8.82917;89.8047;102.383;238.963;109.434;46.9257;113.972;107.32;69.1421 34 79426;246273;79224;24794;24648;252922;192280;83516;29441;25513;25493;299282;288001;24516;54404;50693;306251;24471;25675;29455;25112;294515;25661;361969;83928;24890;24330;116663;140942;25423;113936;114851;25377;25373 ZFP36_10204;TRIB3_10079;SERPIND1_9812;SERPINA3C_32925;SERPINA1_9807;PZP_9633;PPP1R3B_9545;PPARGC1A_33189;POR_9531;PIK3R1_32562;NFKBIA_9307;LOC299282_9119;KNG1L1_34113;JUN_8938;ITIH4_32725;ITIH3_32422;ITIH1_33132;HSPB1_8847;HMGCR_8810;GDF15_33113;GADD45A_8678;FOXO3_8662;FN1_8655;FGA_8632;FETUB_33027;ESR1_33192;EGR1_8533;DUSP6_8506;DDIT4_8450;CTSC_32456;CPB2_8369;CDKN1A_8271;AMBP_33085;AHSG_8003 38.81746947058825 28.420650000000002 32.71375231677749 27.018435882352943 21.9089 23.85603945377428 62.818564411764704 41.2117 52.16845338643054 0.348134;108.064;28.261;29.766;15.797;34.1871;36.1411;42.4094;12.4414;18.7324;0.520151;45.2017;24.3655;16.4324;57.1163;27.1247;98.1741;89.1011;1.63089;105.149;102.919;13.1992;59.5777;28.5803;32.5155;23.3972;0.750017;62.3934;87.5421;56.2386;25.8316;6.24967;17.2343;12.402 0.118102;83.8836;22.307;23.347;13.013;26.3085;27.0588;26.2988;8.48981;11.6701;0.160202;30.7472;19.538;10.5224;39.6402;21.5108;42.9071;60.3265;0.663137;85.3487;89.5012;5.6804;31.0499;22.529;19.6094;18.3088;0.186019;39.0875;53.2453;38.2681;20.4374;2.44025;14.1233;10.3013 1.15962;143.428;38.3264;40.8256;19.9134;48.5666;53.6244;81.7305;79.2355;41.5978;2.88499;78.6415;32.1467;39.929;101.869;36.4819;104.278;106.138;7.6286;125.652;115.437;32.7581;105.243;38.8511;49.9875;31.9156;4.70178;133.304;245.492;102.888;34.8042;19.0606;21.9073;15.4235 0 Exp 2,13(0.3);Exp 3,3(0.07);Exp 4,4(0.1);Hill,3(0.07);Linear,9(0.21);Poly 2,10(0.23);Power,2(0.05) 1.8513296247438438 83.7513210773468 1.5197933912277222 4.21828556060791 0.5311736651636657 1.7003346681594849 33.60704907697813 53.115916468476414 22.486251238002048 35.93207648927067 53.79852441313619 86.38961013231835 DOWN 0.22727272727272727 0.7727272727272727 0.0 GO:0043405 8 regulation of MAP kinase activity 90 99 7 7 7 7 7 7 155 92 2293 0.70791 0.44354 0.67632 7.07 246273;24825;25675;29455;299626;25112;116663 trib3;tf;hmgcr;gdf15;gadd45b;gadd45a;dusp6 TRIB3_10079;TF_10003;HMGCR_8810;GDF15_33113;GADD45B_8679;GADD45A_8678;DUSP6_8506 75.95388428571428 102.919 1.63089 41.2147276090889 83.78211390729238 31.74963798036901 54.18990528571429 52.7132 0.663137 33.84736864006314 63.88210170985737 30.250963498542895 99.48824285714285 115.437 7.6286 48.28861453482445 108.49227792443062 35.32251331754176 3.5 104.03399999999999 108.064;45.1539;1.63089;105.149;106.367;102.919;62.3934 83.8836;28.132;0.663137;85.3487;52.7132;89.5012;39.0875 143.428;61.5341;7.6286;125.652;109.434;115.437;133.304 2 5 2 24825;299626 TF_10003;GADD45B_8679 75.76045 75.76045 43.28419810745022 40.4226 40.4226 17.38153320970276 85.48405 85.48405 33.8703441081575 45.1539;106.367 28.132;52.7132 61.5341;109.434 5 246273;25675;29455;25112;116663 TRIB3_10079;HMGCR_8810;GDF15_33113;GADD45A_8678;DUSP6_8506 76.03125800000001 102.919 45.602346591045276 59.6968274 83.8836 38.86206421722158 105.08992 125.652 55.44008654152698 108.064;1.63089;105.149;102.919;62.3934 83.8836;0.663137;85.3487;89.5012;39.0875 143.428;7.6286;125.652;115.437;133.304 0 Exp 2,1(0.15);Exp 4,1(0.15);Poly 2,4(0.58);Power,1(0.15) 1.7080482317248122 11.996381044387817 1.5527137517929077 1.9017701148986816 0.15190937688630107 1.6357084512710571 45.421586795777536 106.48618177565103 29.1154236981649 79.26438687326366 63.715536596941625 135.26094911734407 DOWN 0.2857142857142857 0.7142857142857143 0.0 GO:0051347 6 positive regulation of transferase activity 183 195 13 13 11 11 9 9 153 186 2199 0.18968 0.88739 0.3604 4.62 246273;24825;303612;29455;299626;25112;29496;24330;114851 trib3;tf;polg2;gdf15;gadd45b;gadd45a;erbb3;egr1;cdkn1a TRIB3_10079;TF_10003;POLG2_9521;GDF15_33113;GADD45B_8679;GADD45A_8678;ERBB3_8571;EGR1_8533;CDKN1A_8271 66.60297633333333 63.7758 0.750017 42.695790912120586 60.811981557242504 44.132473592058176 47.195985444444446 41.6036 0.186019 34.03757261443035 45.57630493224019 37.0807451865084 91.75405333333333 113.972 4.70178 50.778619797697324 83.900831262261 52.37978615469716 108.064;45.1539;63.7758;105.149;106.367;102.919;60.9984;0.750017;6.24967 83.8836;28.132;40.9553;85.3487;52.7132;89.5012;41.6036;0.186019;2.44025 143.428;61.5341;132.567;125.652;109.434;115.437;113.972;4.70178;19.0606 3 6 3 24825;299626;29496 TF_10003;GADD45B_8679;ERBB3_8571 70.83976666666666 60.9984 31.771060358498172 40.81626666666667 41.6036 12.309499124388989 94.98003333333332 109.434 29.053764014380924 45.1539;106.367;60.9984 28.132;52.7132;41.6036 61.5341;109.434;113.972 6 246273;303612;29455;25112;24330;114851 TRIB3_10079;POLG2_9521;GDF15_33113;GADD45A_8678;EGR1_8533;CDKN1A_8271 64.48458116666666 83.3474 49.96772393216778 50.38584483333333 62.41945 41.91002172726327 90.14106333333332 120.5445 61.46978470817079 108.064;63.7758;105.149;102.919;0.750017;6.24967 83.8836;40.9553;85.3487;89.5012;0.186019;2.44025 143.428;132.567;125.652;115.437;4.70178;19.0606 0 Exp 2,1(0.12);Exp 4,1(0.12);Hill,1(0.12);Linear,1(0.12);Poly 2,4(0.45);Power,1(0.12) 1.8183744482248383 17.351049661636353 1.522104263305664 4.21828556060791 0.8684060458583901 1.6013026237487793 38.708392937414544 94.49755972925212 24.958104669683284 69.43386621920561 58.57868839883775 124.92941826782894 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0051592 6 response to calcium ion 51 56 5 5 4 5 4 4 158 52 2333 0.71769 0.48181 0.77907 7.14 24516;314322;361969;155423 jun;fos;fga;anxa7 JUN_8938;FOS_8657;FGA_8632;ANXA7_8051 37.41317500000032 22.50635 1.28141E-12 46.32279591276633 42.12204357986281 43.099296180458204 19.24420000000032 16.5257 1.28141E-12 18.853475129357903 23.093009475816565 16.36169576430287 46.86727500000032 39.39005 1.28142E-12 45.20643711356227 51.92590981176835 40.57635899486822 1.5 22.50635 16.4324;1.28141E-12;28.5803;104.64 10.5224;1.28141E-12;22.529;43.9254 39.929;1.28142E-12;38.8511;108.689 1 3 1 155423 ANXA7_8051 104.64 104.64 43.9254 43.9254 108.689 108.689 104.64 43.9254 108.689 3 24516;314322;361969 JUN_8938;FOS_8657;FGA_8632 15.004233333333763 16.4324 14.343574590851263 11.01713333333376 10.5224 11.272645255365715 26.260033333333762 38.8511 22.74824125296942 16.4324;1.28141E-12;28.5803 10.5224;1.28141E-12;22.529 39.929;1.28142E-12;38.8511 0 Exp 3,1(0.25);Hill,1(0.25);Linear,1(0.25);Poly 2,1(0.25) 1.7294608703837278 6.963246941566467 1.541895866394043 1.9785058498382568 0.22966636664514392 1.7214226126670837 -7.98316499451068 82.80951499451132 0.7677943732295738 37.72060562677106 2.5649666287093 91.16958337129134 DOWN 0.25 0.75 0.0 GO:0002244 5 hematopoietic progenitor cell differentiation 30 31 4 4 3 3 3 3 159 28 2357 0.86955 0.31516 0.44393 9.68 29573;297784;25695 slc37a4;rrs1;cebpd SLC37A4_9871;RRS1_9755;CEBPD_8283 33.47117866666667 39.7166 0.306936 30.52454112071409 32.13730167073589 28.460089677076677 21.957778066666666 22.6911 0.0732342 21.52725261828697 20.398248981095264 19.66969723573894 55.57076333333333 60.0334 1.73689 51.74707747343837 52.26758381460353 47.54613569193202 0.5 20.011768 39.7166;60.39;0.306936 22.6911;43.109;0.0732342 60.0334;104.942;1.73689 1 2 1 297784 RRS1_9755 60.39 60.39 43.109 43.109 104.942 104.942 60.39 43.109 104.942 2 29573;25695 SLC37A4_9871;CEBPD_8283 20.011768 20.011768 27.86684065868336 11.3821671 11.3821671 15.993246283147295 30.885145 30.885145 41.221857540509376 39.7166;0.306936 22.6911;0.0732342 60.0334;1.73689 0 Exp 2,1(0.34);Hill,1(0.34);Poly 2,1(0.34) 1.9159734776086121 5.803248167037964 1.627708911895752 2.281954288482666 0.3290283218345252 1.893584966659546 -1.070591317884137 68.01294865121747 -2.4026015177322044 46.31815765106555 -2.9865673204361514 114.12809398710282 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0090276 6 regulation of peptide hormone secretion 58 63 9 9 8 8 7 7 155 56 2329 0.95639 0.10184 0.11694 11.11 293615;81819;100359982;25675;113965;24957;361969 sirt3;pax8;mpc2;hmgcr;hadh;glul;fga SIRT3_9828;PAX8_9432;MPC2_33219;HMGCR_8810;HADH_8776;GLUL_32832;FGA_8632 28.015738571428567 28.5803 1.63089 20.70671169917332 33.04859076977419 18.666931755095426 21.642718142857145 22.529 0.56209 16.609471332599984 25.720676227374796 15.04896362454918 41.20293857142857 38.8511 7.6286 27.85901036619477 47.554315421470925 25.701138257665452 2.5 27.523600000000002 5.5 51.869699999999995 2.38018;56.8931;46.8463;1.63089;33.3125;26.4669;28.5803 0.56209;45.1162;35.8494;0.663137;25.7336;21.0456;22.529 8.82917;81.5688;69.127;7.6286;46.9856;35.4303;38.8511 4 3 4 293615;81819;100359982;113965 SIRT3_9828;PAX8_9432;MPC2_33219;HADH_8776 34.85802 40.0794 23.709789336198934 26.8153225 30.7915 19.208843569322223 51.62764249999999 58.05629999999999 31.916339766425164 2.38018;56.8931;46.8463;33.3125 0.56209;45.1162;35.8494;25.7336 8.82917;81.5688;69.127;46.9856 3 25675;24957;361969 HMGCR_8810;GLUL_32832;FGA_8632 18.892696666666666 26.4669 14.986463623484806 14.745912333333331 21.0456 12.218573554505305 27.30333333333333 35.4303 17.12445085143852 1.63089;26.4669;28.5803 0.663137;21.0456;22.529 7.6286;35.4303;38.8511 0 Exp 2,2(0.29);Exp 4,1(0.15);Hill,1(0.15);Linear,3(0.43) 1.8336779415923028 12.965637683868408 1.5209722518920898 2.3622660636901855 0.2875426737967891 1.9017701148986816 12.675991876169777 43.355485266687374 9.33824958764862 33.947186698065664 20.564694875058457 61.84118226779868 CONFLICT 0.5714285714285714 0.42857142857142855 0.0 GO:0035902 4 response to immobilization stress 19 21 2 2 2 2 2 2 160 19 2366 0.85485 0.39001 0.39001 9.52 294515;314322 foxo3;fos FOXO3_8662;FOS_8657 6.59960000000064 6.59960000000064 1.28141E-12 9.333243826236572 5.557723811799165 9.216204660102802 2.8402000000006407 2.8402000000006407 1.28141E-12 4.016649359851158 2.391818772391475 3.966280452697226 16.37905000000064 16.37905000000064 1.28142E-12 23.163474648786135 13.793295987581349 22.873003960552996 0.5 6.59960000000064 13.1992;1.28141E-12 5.6804;1.28141E-12 32.7581;1.28142E-12 0 2 0 2 294515;314322 FOXO3_8662;FOS_8657 6.59960000000064 6.59960000000064 9.333243826236572 2.8402000000006407 2.8402000000006407 4.016649359851158 16.37905000000064 16.37905000000064 23.163474648786135 13.1992;1.28141E-12 5.6804;1.28141E-12 32.7581;1.28142E-12 0 Exp 4,1(0.5);Hill,1(0.5) 1.9419638940171529 3.885009527206421 1.8966681957244873 1.9883413314819336 0.06482269594672524 1.9425047636032104 -6.335615999998103 19.53481599999938 -2.726591999998102 8.406991999999384 -15.723887999998105 48.48198799999938 DOWN 0.0 1.0 0.0 GO:0006970 4 response to osmotic stress 32 33 4 4 3 3 2 2 160 31 2354 0.64906 0.63119 1.0 6.06 25256;155423 fmo1;anxa7 FMO1_32787;ANXA7_8051 84.9596 84.9596 65.2792 27.83228859292749 83.74103873765803 27.778885960740734 41.85680000000001 41.85680000000001 39.7882 2.9254421751248807 41.728717449478644 2.919829043026929 95.81524999999999 95.81524999999999 82.9415 18.206231848600737 95.01813952200793 18.17129901511595 0.5 84.9596 65.2792;104.64 39.7882;43.9254 82.9415;108.689 2 0 2 25256;155423 FMO1_32787;ANXA7_8051 84.9596 84.9596 27.83228859292749 41.85680000000001 41.85680000000001 2.9254421751248807 95.81524999999999 95.81524999999999 18.206231848600737 65.2792;104.64 39.7882;43.9254 82.9415;108.689 0 0 Exp 3,1(0.5);Poly 2,1(0.5) 1.7518533596889514 3.5310662984848022 1.5461770296096802 1.984889268875122 0.3102163993741291 1.7655331492424011 46.386016 123.53318399999999 37.802344000000005 45.91125600000001 70.5827 121.04779999999998 UP 1.0 0.0 0.0 GO:0051716 3 cellular response to stimulus 785 838 75 74 59 66 52 52 110 786 1599 0.44837 0.61912 0.86308 6.21 79426;286954;246273;24825;170698;29482;83516;29441;303612;24651;25513;81819;25591;24314;81525;25493;24567;24539;89783;58954;24516;81678;192235;63868;24471;81869;24957;25112;294515;314322;25661;361969;24360;24890;29496;25315;116636;24330;140942;25428;25146;497840;113936;114851;29184;246142;25698;65054;25373;170465;312382;25303 zfp36;ugt2b1;trib3;tf;slco1a2;slc1a2;ppargc1a;por;polg2;pklr;pik3r1;pax8;parp1;nqo1;nfkbib;nfkbia;mt1;lpl;laptm5;klf6;jun;itpr2;hyou1;hspd1;hspb1;gstm7;glul;gadd45a;foxo3;fos;fn1;fga;fabp1;esr1;erbb3;ephx1;eif4ebp1;egr1;ddit4;cyp7a1;cyp17a1;cps1;cpb2;cdkn1a;cd36;bmf;ass1;aqp9;ahsg;acaa2;abcg2;abcc2 ZFP36_10204;UGT2B10_33303,UGT2B1_33224;TRIB3_10079;TF_10003;SLCO1A2_9886;SLC1A2_33059;PPARGC1A_33189;POR_9531;POLG2_9521;PKLR_9489;PIK3R1_32562;PAX8_9432;PARP1_9425;NQO1_33055;NFKBIB_9308;NFKBIA_9307;MT1A_9255;LPL_32544;LAPTM5_32639;KLF6_8969;JUN_8938;ITPR2_8931;HYOU1_8857;HSPD1_8849;HSPB1_8847;GSTM7_8761;GLUL_32832;GADD45A_8678;FOXO3_8662;FOS_8657;FN1_8655;FGA_8632;FABP1_33091;ESR1_33192;ERBB3_8571;EPHX1_8567;EIF4EBP1_8550;EGR1_8533;DDIT4_8450;CYP7A1_8430;CYP17A1_32365;CPS1_32421;CPB2_8369;CDKN1A_8271;CD36_8243;BMF_8152;ASS1_33159;AQP9_32709;AHSG_8003;ACAA2_7955;ABCG2_32656;ABCC2_32541 39.02344503846156 31.184150000000002 1.28141E-12 29.81916981253387 41.58346371196327 28.90218849383816 27.517961269230792 24.095399999999998 1.28141E-12 22.08823995605848 29.539324274223205 21.86060729782103 64.98282961538465 45.5686 1.28142E-12 50.53719515756523 65.82668534053442 43.31919049228662 40.5 60.28805 0.348134;47.47345;108.064;45.1539;104.197;13.3235;42.4094;12.4414;63.7758;23.0963;18.7324;56.8931;26.9741;87.2765;30.5572;0.520151;12.9315;74.2041;38.674;18.9476;16.4324;31.8111;40.1982;42.2579;89.1011;42.3152;26.4669;102.919;13.1992;1.28141E-12;59.5777;28.5803;33.8478;23.3972;60.9984;12.4747;83.9001;0.750017;87.5421;5.72128;49.6922;31.9826;25.8316;6.24967;48.1296;94.8767;26.8037;27.7316;12.402;26.5872;5.21654;46.2316 0.118102;34.82915;83.8836;28.132;80.3101;9.10952;26.2988;8.48981;40.9553;17.4625;11.6701;45.1162;21.799;60.6992;24.2439;0.160202;8.91033;49.8682;24.6273;11.6941;10.5224;24.7342;29.3844;23.9469;60.3265;31.4035;21.0456;89.5012;5.6804;1.28141E-12;31.0499;22.529;26.4736;18.3088;41.6036;7.00435;42.4185;0.186019;53.2453;0.985273;35.6654;24.4836;20.4374;2.44025;37.5433;73.1342;20.9825;21.9372;10.3013;21.3695;2.73368;31.1788 1.15962;76.47475;143.428;61.5341;128.412;24.6773;81.7305;79.2355;132.567;32.9443;41.5978;81.5688;35.2797;197.117;41.2611;2.88499;23.4636;155.425;71.0786;45.5481;39.929;44.3296;62.3571;102.383;106.138;64.5991;35.4303;115.437;32.7581;1.28142E-12;105.243;38.8511;46.9257;31.9156;113.972;23.684;107.32;4.70178;245.492;22.3625;81.6409;45.5891;34.8042;19.0606;69.1421;109.848;36.7081;37.4625;15.4235;35.0407;11.386;81.7848 19 34 18 286954;24825;81819;25591;24314;81525;24539;63868;81869;24360;29496;25315;116636;25146;29184;246142;170465;312382 UGT2B10_33303,UGT2B1_33224;TF_10003;PAX8_9432;PARP1_9425;NQO1_33055;NFKBIB_9308;LPL_32544;HSPD1_8849;GSTM7_8761;FABP1_33091;ERBB3_8571;EPHX1_8567;EIF4EBP1_8550;CYP17A1_32365;CD36_8243;BMF_8152;ACAA2_7955;ABCG2_32656 48.26826055555556 46.313675 24.895595188733683 33.77689888888889 33.116325 17.273438609242163 78.5889972222222 72.808425 47.198421743318306 47.47345;45.1539;56.8931;26.9741;87.2765;30.5572;74.2041;42.2579;42.3152;33.8478;60.9984;12.4747;83.9001;49.6922;48.1296;94.8767;26.5872;5.21654 34.82915;28.132;45.1162;21.799;60.6992;24.2439;49.8682;23.9469;31.4035;26.4736;41.6036;7.00435;42.4185;35.6654;37.5433;73.1342;21.3695;2.73368 76.47475;61.5341;81.5688;35.2797;197.117;41.2611;155.425;102.383;64.5991;46.9257;113.972;23.684;107.32;81.6409;69.1421;109.848;35.0407;11.386 34 79426;246273;170698;29482;83516;29441;303612;24651;25513;25493;24567;89783;58954;24516;81678;192235;24471;24957;25112;294515;314322;25661;361969;24890;24330;140942;25428;497840;113936;114851;25698;65054;25373;25303 ZFP36_10204;TRIB3_10079;SLCO1A2_9886;SLC1A2_33059;PPARGC1A_33189;POR_9531;POLG2_9521;PKLR_9489;PIK3R1_32562;NFKBIA_9307;MT1A_9255;LAPTM5_32639;KLF6_8969;JUN_8938;ITPR2_8931;HYOU1_8857;HSPB1_8847;GLUL_32832;GADD45A_8678;FOXO3_8662;FOS_8657;FN1_8655;FGA_8632;ESR1_33192;EGR1_8533;DDIT4_8450;CYP7A1_8430;CPS1_32421;CPB2_8369;CDKN1A_8271;ASS1_33159;AQP9_32709;AHSG_8003;ABCC2_32541 34.12913094117651 26.149250000000002 31.362514045647444 24.204406058823572 20.70995 23.824893741891497 57.77956441176474 39.39005 51.43021344261937 0.348134;108.064;104.197;13.3235;42.4094;12.4414;63.7758;23.0963;18.7324;0.520151;12.9315;38.674;18.9476;16.4324;31.8111;40.1982;89.1011;26.4669;102.919;13.1992;1.28141E-12;59.5777;28.5803;23.3972;0.750017;87.5421;5.72128;31.9826;25.8316;6.24967;26.8037;27.7316;12.402;46.2316 0.118102;83.8836;80.3101;9.10952;26.2988;8.48981;40.9553;17.4625;11.6701;0.160202;8.91033;24.6273;11.6941;10.5224;24.7342;29.3844;60.3265;21.0456;89.5012;5.6804;1.28141E-12;31.0499;22.529;18.3088;0.186019;53.2453;0.985273;24.4836;20.4374;2.44025;20.9825;21.9372;10.3013;31.1788 1.15962;143.428;128.412;24.6773;81.7305;79.2355;132.567;32.9443;41.5978;2.88499;23.4636;71.0786;45.5481;39.929;44.3296;62.3571;106.138;35.4303;115.437;32.7581;1.28142E-12;105.243;38.8511;31.9156;4.70178;245.492;22.3625;45.5891;34.8042;19.0606;36.7081;37.4625;15.4235;81.7848 0 Exp 2,21(0.4);Exp 3,2(0.04);Exp 4,4(0.08);Hill,5(0.1);Linear,8(0.16);Poly 2,12(0.23);Power,1(0.02) 1.9105481328923022 104.74645948410034 1.5074360370635986 4.560328960418701 0.6159020362678478 1.7792335748672485 30.91850235878143 47.128387718141674 21.514309260661957 33.52161327779963 51.246663500803315 78.71899572996597 DOWN 0.34615384615384615 0.6538461538461539 0.0 GO:0009653 3 anatomical structure morphogenesis 282 299 12 12 10 11 9 9 153 290 2095 0.0049317 0.99807 0.010967 3.01 308843;303612;81819;24516;65164;294515;25661;24890;29496 tsku;polg2;pax8;jun;htra1;foxo3;fn1;esr1;erbb3 TSKU_10094;POLG2_9521;PAX8_9432;JUN_8938;HTRA1_8856;FOXO3_8662;FN1_8655;ESR1_33192;ERBB3_8571 36.53225111111111 33.1323 1.38416 24.12046100390726 45.93622436515374 20.418242441683674 24.376852 25.6145 0.540568 16.56155385978128 30.535153165974915 13.916246151984655 65.41390222222223 46.6629 4.10872 44.24746958359928 79.22640762931228 38.13154285076537 1.38416;63.7758;56.8931;16.4324;33.1323;13.1992;59.5777;23.3972;60.9984 0.540568;40.9553;45.1162;10.5224;25.6145;5.6804;31.0499;18.3088;41.6036 4.10872;132.567;81.5688;39.929;46.6629;32.7581;105.243;31.9156;113.972 2 7 2 81819;29496 PAX8_9432;ERBB3_8571 58.94575 58.94575 2.902885468805186 43.359899999999996 43.359899999999996 2.4837832795959702 97.7704 97.7704 22.912522452143893 56.8931;60.9984 45.1162;41.6036 81.5688;113.972 7 308843;303612;24516;65164;294515;25661;24890 TSKU_10094;POLG2_9521;JUN_8938;HTRA1_8856;FOXO3_8662;FN1_8655;ESR1_33192 30.128394285714286 23.3972 23.64371244015827 18.953124 18.3088 14.499892815448627 56.16918857142857 39.929 45.54409186164086 1.38416;63.7758;16.4324;33.1323;13.1992;59.5777;23.3972 0.540568;40.9553;10.5224;25.6145;5.6804;31.0499;18.3088 4.10872;132.567;39.929;46.6629;32.7581;105.243;31.9156 0 Exp 2,3(0.34);Exp 4,1(0.12);Hill,1(0.12);Linear,2(0.23);Poly 2,1(0.12);Power,1(0.12) 1.9137862967134456 17.621737003326416 1.5504547357559204 2.9744045734405518 0.47297494988848543 1.7792335748672485 20.773549921891693 52.290952300330524 13.556636811609566 35.197067188390434 36.50555542760402 94.32224901684042 DOWN 0.2222222222222222 0.7777777777777778 0.0 GO:1904035 8 regulation of epithelial cell apoptotic process 41 44 5 5 5 4 4 4 158 40 2345 0.85591 0.30563 0.35972 9.09 79426;83516;294515;361969 zfp36;ppargc1a;foxo3;fga ZFP36_10204;PPARGC1A_33189;FOXO3_8662;FGA_8632 21.1342585 20.88975 0.348134 18.28572580815126 27.741104879471184 15.300224446095394 13.656575499999999 14.1047 0.118102 12.720788722056549 19.30589311274588 10.461280943120052 38.62483 35.8046 1.15962 33.147199306018805 46.2728300239885 29.747873387733073 1.5 20.88975 0.348134;42.4094;13.1992;28.5803 0.118102;26.2988;5.6804;22.529 1.15962;81.7305;32.7581;38.8511 0 4 0 4 79426;83516;294515;361969 ZFP36_10204;PPARGC1A_33189;FOXO3_8662;FGA_8632 21.1342585 20.88975 18.28572580815126 13.656575499999999 14.1047 12.720788722056549 38.62483 35.8046 33.147199306018805 0.348134;42.4094;13.1992;28.5803 0.118102;26.2988;5.6804;22.529 1.15962;81.7305;32.7581;38.8511 0 Exp 2,1(0.25);Exp 4,1(0.25);Hill,1(0.25);Linear,1(0.25) 1.7976960500732933 7.226036787033081 1.541895866394043 1.9883413314819336 0.20232751887025804 1.8478997945785522 3.2142472080117663 39.05426979198823 1.1902025523845836 26.122948447615414 6.140574680101565 71.10908531989843 DOWN 0.0 1.0 0.0 GO:0003420 6 regulation of growth plate cartilage chondrocyte proliferation 1 1 1 1 1 1 1 1 161 0 2385 1.0 0.063604 0.063604 100.0 29441 por POR_9531 12.4414 12.4414 12.4414 12.4414 8.48981 8.48981 8.48981 8.48981 79.2355 79.2355 79.2355 79.2355 0.0 12.4414 0.0 12.4414 12.4414 8.48981 79.2355 0 1 0 1 29441 POR_9531 12.4414 12.4414 8.48981 8.48981 79.2355 79.2355 12.4414 8.48981 79.2355 0 Poly 2,1(1) 1.9819281101226807 1.9819281101226807 1.9819281101226807 1.9819281101226807 0.0 1.9819281101226807 12.4414 12.4414 8.48981 8.48981 79.2355 79.2355 DOWN 0.0 1.0 0.0 GO:0043602 6 nitrate catabolic process 1 1 1 1 1 1 1 1 161 0 2385 1.0 0.063604 0.063604 100.0 29441 por POR_9531 12.4414 12.4414 12.4414 12.4414 8.48981 8.48981 8.48981 8.48981 79.2355 79.2355 79.2355 79.2355 0.0 12.4414 0.0 12.4414 12.4414 8.48981 79.2355 0 1 0 1 29441 POR_9531 12.4414 12.4414 8.48981 8.48981 79.2355 79.2355 12.4414 8.48981 79.2355 0 Poly 2,1(1) 1.9819281101226807 1.9819281101226807 1.9819281101226807 1.9819281101226807 0.0 1.9819281101226807 12.4414 12.4414 8.48981 8.48981 79.2355 79.2355 DOWN 0.0 1.0 0.0 GO:0046210 6 nitric oxide catabolic process 1 1 1 1 1 1 1 1 161 0 2385 1.0 0.063604 0.063604 100.0 29441 por POR_9531 12.4414 12.4414 12.4414 12.4414 8.48981 8.48981 8.48981 8.48981 79.2355 79.2355 79.2355 79.2355 0.0 12.4414 0.0 12.4414 12.4414 8.48981 79.2355 0 1 0 1 29441 POR_9531 12.4414 12.4414 8.48981 8.48981 79.2355 79.2355 12.4414 8.48981 79.2355 0 Poly 2,1(1) 1.9819281101226807 1.9819281101226807 1.9819281101226807 1.9819281101226807 0.0 1.9819281101226807 12.4414 12.4414 8.48981 8.48981 79.2355 79.2355 DOWN 0.0 1.0 0.0 GO:0006725 4 cellular aromatic compound metabolic process 429 482 61 60 42 54 37 37 125 445 1940 0.91953 0.11436 0.21288 7.68 79426;286954;24856;360268;297784;298490;303612;24651;81819;25591;294103;100359982;24516;364070;63868;25675;24443;81869;499914;294515;314322;308441;24890;65030;25315;24330;24894;25146;83842;497840;25028;192272;170570;50559;170465;312382;296925 zfp36;ugt2b1;ttr;sult1e1;rrs1;ppcs;polg2;pklr;pax8;parp1;papss2;mpc2;jun;iars2;hspd1;hmgcr;hdc;gstm7;gins1;foxo3;fos;exosc5;esr1;ephx2;ephx1;egr1;cyp2a1;cyp17a1;crot;cps1;ampd1;acot2;acot12;acot1;acaa2;abcg2;aass ZFP36_10204;UGT2B10_33303,UGT2B1_33224;TTR_10102;SULT1E1_32446;RRS1_9755;PPCS_9540;POLG2_9521;PKLR_9489;PAX8_9432;PARP1_9425;PAPSS2_33237;MPC2_33219;JUN_8938;IARS2_8858;HSPD1_8849;HMGCR_8810;HDC_8788;GSTM7_8761;GINS1_8707;FOXO3_8662;FOS_8657;EXOSC5_32543;ESR1_33192;EPHX2_33282;EPHX1_8567;EGR1_8533;CYP2A1_32717;CYP17A1_32365;CROT_8384;CPS1_32421;AMPD1_32743;ACOT2_7969;ACOT12_32718;ACOT1_7968;ACAA2_7955;ABCG2_32656;AASS_7936 31.175683270270305 30.3423 1.28141E-12 19.326010128326995 34.02879003432208 18.672471899397564 22.964628864864906 23.9469 1.28141E-12 14.348105177112078 25.2181650925469 14.12096986519531 49.340839189189225 39.929 1.28142E-12 33.11046291697449 53.053174016243794 31.66537616222596 23.5 42.0954 0.348134;47.47345;46.6406;50.1846;60.39;20.3353;63.7758;23.0963;56.8931;26.9741;34.4443;46.8463;16.4324;24.7304;42.2579;1.63089;24.5745;42.3152;58.9165;13.1992;1.28141E-12;41.9329;23.3972;38.7293;12.4747;0.750017;55.3937;49.6922;7.4229;31.9826;60.9045;8.54905;30.3423;31.2018;26.5872;5.21654;27.4644 0.118102;34.82915;28.5876;36.5009;43.109;16.7643;40.9553;17.4625;45.1162;21.799;25.719;35.8494;10.5224;19.8021;23.9469;0.663137;21.0619;31.4035;44.7208;5.6804;1.28141E-12;31.7336;18.3088;29.2097;7.00435;0.186019;38.7444;35.6654;5.75707;24.4836;50.0633;7.19676;24.0157;26.858;21.3695;2.73368;21.7498 1.15962;76.47475;63.7146;80.9788;104.942;25.6711;132.567;32.9443;81.5688;35.2797;51.1014;69.127;39.929;32.7087;102.383;7.6286;29.28;64.5991;91.837;32.7581;1.28142E-12;62.1373;31.9156;57.2113;23.684;4.70178;96.8569;81.6409;10.316;45.5891;82.6625;10.4125;41.1025;37.2719;35.0407;11.386;37.0295 27 11 26 286954;24856;360268;297784;298490;81819;25591;100359982;364070;63868;24443;81869;499914;308441;65030;25315;24894;25146;83842;25028;192272;170570;50559;170465;312382;296925 UGT2B10_33303,UGT2B1_33224;TTR_10102;SULT1E1_32446;RRS1_9755;PPCS_9540;PAX8_9432;PARP1_9425;MPC2_33219;IARS2_8858;HSPD1_8849;HDC_8788;GSTM7_8761;GINS1_8707;EXOSC5_32543;EPHX2_33282;EPHX1_8567;CYP2A1_32717;CYP17A1_32365;CROT_8384;AMPD1_32743;ACOT2_7969;ACOT12_32718;ACOT1_7968;ACAA2_7955;ABCG2_32656;AASS_7936 36.324747692307696 40.3311 17.08238201945087 27.13815423076924 27.7228 12.733820772590489 55.58909807692308 59.6743 29.72104356899495 47.47345;46.6406;50.1846;60.39;20.3353;56.8931;26.9741;46.8463;24.7304;42.2579;24.5745;42.3152;58.9165;41.9329;38.7293;12.4747;55.3937;49.6922;7.4229;60.9045;8.54905;30.3423;31.2018;26.5872;5.21654;27.4644 34.82915;28.5876;36.5009;43.109;16.7643;45.1162;21.799;35.8494;19.8021;23.9469;21.0619;31.4035;44.7208;31.7336;29.2097;7.00435;38.7444;35.6654;5.75707;50.0633;7.19676;24.0157;26.858;21.3695;2.73368;21.7498 76.47475;63.7146;80.9788;104.942;25.6711;81.5688;35.2797;69.127;32.7087;102.383;29.28;64.5991;91.837;62.1373;57.2113;23.684;96.8569;81.6409;10.316;82.6625;10.4125;41.1025;37.2719;35.0407;11.386;37.0295 11 79426;303612;24651;294103;24516;25675;294515;314322;24890;24330;497840 ZFP36_10204;POLG2_9521;PKLR_9489;PAPSS2_33237;JUN_8938;HMGCR_8810;FOXO3_8662;FOS_8657;ESR1_33192;EGR1_8533;CPS1_32421 19.005167363636478 16.4324 19.57534964202729 13.099932545454662 10.5224 13.543215570319518 34.57222727272739 32.7581 37.37525692130361 0.348134;63.7758;23.0963;34.4443;16.4324;1.63089;13.1992;1.28141E-12;23.3972;0.750017;31.9826 0.118102;40.9553;17.4625;25.719;10.5224;0.663137;5.6804;1.28141E-12;18.3088;0.186019;24.4836 1.15962;132.567;32.9443;51.1014;39.929;7.6286;32.7581;1.28142E-12;31.9156;4.70178;45.5891 0 Exp 2,20(0.53);Exp 3,1(0.03);Exp 4,3(0.08);Hill,4(0.11);Linear,7(0.19);Poly 2,3(0.08) 2.616232857592255 450.0602626800537 1.5074360370635986 344.14306640625 55.44619075673551 1.9158924221992493 24.948417342520237 37.40294919802038 18.341353501563646 27.58790422816614 38.67191910657532 60.00975927180312 UP 0.7027027027027027 0.2972972972972973 0.0 GO:0048016 7 inositol phosphate-mediated signaling 7 7 1 1 1 1 1 1 161 6 2379 0.93166 0.36908 0.36908 14.29 81678 itpr2 ITPR2_8931 31.8111 31.8111 31.8111 31.8111 24.7342 24.7342 24.7342 24.7342 44.3296 44.3296 44.3296 44.3296 0.0 31.8111 0.0 31.8111 31.8111 24.7342 44.3296 0 1 0 1 81678 ITPR2_8931 31.8111 31.8111 24.7342 24.7342 44.3296 44.3296 31.8111 24.7342 44.3296 0 Linear,1(1) 1.6674995422363281 1.6674995422363281 1.6674995422363281 1.6674995422363281 0.0 1.6674995422363281 31.8111 31.8111 24.7342 24.7342 44.3296 44.3296 DOWN 0.0 1.0 0.0 GO:0071480 7 cellular response to gamma radiation 15 15 2 2 2 2 2 2 160 13 2372 0.93468 0.24652 0.24652 13.33 24330;114851 egr1;cdkn1a EGR1_8533;CDKN1A_8271 3.4998435 3.4998435 0.750017 3.8888419304729402 3.9785189960838063 3.8294687750525327 1.3131344999999999 1.3131344999999999 0.186019 1.5939820264609321 1.5093369044448792 1.569645798790477 11.88119 11.88119 4.70178 10.153218991837024 13.130944354807127 9.998204038800235 0.0 0.750017 0.5 3.4998435 0.750017;6.24967 0.186019;2.44025 4.70178;19.0606 0 2 0 2 24330;114851 EGR1_8533;CDKN1A_8271 3.4998435 3.4998435 3.8888419304729402 1.3131344999999999 1.3131344999999999 1.5939820264609321 11.88119 11.88119 10.153218991837024 0.750017;6.24967 0.186019;2.44025 4.70178;19.0606 0 Exp 4,1(0.5);Hill,1(0.5) 2.5339041883311264 5.740389823913574 1.522104263305664 4.21828556060791 1.9064880786307612 2.870194911956787 -1.8898164399999993 8.88950344 -0.8960118799999996 3.5222808799999994 -2.1904535999999997 25.952833599999998 DOWN 0.0 1.0 0.0 GO:0008104 4 protein localization 289 309 17 16 12 15 11 11 151 298 2087 0.016319 0.99239 0.03359 3.56 171139;297784;308821;25513;25493;63868;24471;85255;24890;114851;29184 timm9;rrs1;rab30;pik3r1;nfkbia;hspd1;hspb1;hacl1;esr1;cdkn1a;cd36 TIMM9_10020;RRS1_9755;RAB30_9639;PIK3R1_32562;NFKBIA_9307;HSPD1_8849;HSPB1_8847;HACL1_8775;ESR1_33192;CDKN1A_8271;CD36_8243 171139(0.04986) 33.75862918181818 26.4203 0.520151 25.655786727580846 37.63241236822818 27.49613709387621 23.56932290909091 21.0125 0.160202 18.131251001710638 26.001748057952405 19.561581695357543 55.140190000000004 41.5978 2.88499 36.001888787524734 60.90507922856063 36.05054110088618 38.5191;60.39;26.4203;18.7324;0.520151;42.2579;89.1011;17.6275;23.3972;6.24967;48.1296 29.55;43.109;21.0125;11.6701;0.160202;23.9469;60.3265;11.195;18.3088;2.44025;37.5433 55.4685;104.942;35.3561;41.5978;2.88499;102.383;106.138;37.6534;31.9156;19.0606;69.1421 6 5 6 171139;297784;308821;63868;85255;29184 TIMM9_10020;RRS1_9755;RAB30_9639;HSPD1_8849;HACL1_8775;CD36_8243 38.89073333333334 40.3885 15.275390970402913 27.726116666666666 26.74845 11.566932906076133 67.49085000000001 62.3053 30.627536218556646 38.5191;60.39;26.4203;42.2579;17.6275;48.1296 29.55;43.109;21.0125;23.9469;11.195;37.5433 55.4685;104.942;35.3561;102.383;37.6534;69.1421 5 25513;25493;24471;24890;114851 PIK3R1_32562;NFKBIA_9307;HSPB1_8847;ESR1_33192;CDKN1A_8271 27.600104199999997 18.7324 35.594374456251565 18.5811704 11.6701 24.44571031527885 40.319398 31.9156 39.55255331975447 18.7324;0.520151;89.1011;23.3972;6.24967 11.6701;0.160202;60.3265;18.3088;2.44025 41.5978;2.88499;106.138;31.9156;19.0606 0 Exp 2,4(0.37);Exp 3,1(0.1);Exp 4,2(0.19);Linear,1(0.1);Poly 2,3(0.28) 2.0129709040352552 22.67259991168976 1.522104263305664 2.945132255554199 0.4802495982502404 1.8546061515808105 18.597028107049027 48.92023025658733 12.85443828702162 34.2842075311602 33.86443332449524 76.41594667550477 CONFLICT 0.5454545454545454 0.45454545454545453 0.0 GO:2001243 8 negative regulation of intrinsic apoptotic signaling pathway 39 41 3 3 2 3 2 2 160 39 2346 0.51033 0.74666 1.0 4.88 192235;24471 hyou1;hspb1 HYOU1_8857;HSPB1_8847 64.64965000000001 64.64965000000001 40.1982 34.57957220968759 74.03562305769422 31.930453077359832 44.855450000000005 44.855450000000005 29.3844 21.879368734152266 50.79419222077792 20.20320414873091 84.24755 84.24755 62.3571 30.957771276450114 92.65045346465354 28.58611602041146 40.1982;89.1011 29.3844;60.3265 62.3571;106.138 0 2 0 2 192235;24471 HYOU1_8857;HSPB1_8847 64.64965000000001 64.64965000000001 34.57957220968759 44.855450000000005 44.855450000000005 21.879368734152266 84.24755 84.24755 30.957771276450114 40.1982;89.1011 29.3844;60.3265 62.3571;106.138 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.674551936443014 3.3494092226028442 1.6520916223526 1.6973176002502441 0.03197959565721702 1.6747046113014221 16.72480800000001 112.574492 14.532192000000006 75.178708 41.342268000000004 127.152832 DOWN 0.0 1.0 0.0 GO:0051101 5 regulation of DNA binding 31 33 4 4 4 2 2 2 160 31 2354 0.64906 0.63119 1.0 6.06 25591;24516 parp1;jun PARP1_9425;JUN_8938 21.70325 21.70325 16.4324 7.454107555234224 23.65099014171834 6.926495226712978 16.1607 16.1607 10.5224 7.973760328728228 18.244224145261292 7.4093662382302625 37.60435 37.60435 35.2797 3.2875515577707235 36.745320788308234 3.0548539853682675 0.5 21.70325 26.9741;16.4324 21.799;10.5224 35.2797;39.929 1 1 1 25591 PARP1_9425 26.9741 26.9741 21.799 21.799 35.2797 35.2797 26.9741 21.799 35.2797 1 24516 JUN_8938 16.4324 16.4324 10.5224 10.5224 39.929 39.929 16.4324 10.5224 39.929 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.891682731010723 3.7871755361557007 1.8086696863174438 1.9785058498382568 0.12009230291627422 1.8935877680778503 11.372384000000002 32.034116 5.1096319999999995 27.211768 33.048035999999996 42.160664 CONFLICT 0.5 0.5 0.0 GO:0090501 7 RNA phosphodiester bond hydrolysis 18 22 3 2 2 3 2 2 160 20 2365 0.83934 0.41295 0.64706 9.09 297784;308441 rrs1;exosc5 RRS1_9755;EXOSC5_32543 51.16145 51.16145 41.9329 13.051140571038191 56.353792068198665 10.789413232360179 37.4213 37.4213 31.7336 8.043622478709436 40.62142179392143 6.649684472825618 83.53965 83.53965 62.1373 30.26749363665582 95.58144662713121 25.02221890693588 0.5 51.16145 60.39;41.9329 43.109;31.7336 104.942;62.1373 2 0 2 297784;308441 RRS1_9755;EXOSC5_32543 51.16145 51.16145 13.051140571038191 37.4213 37.4213 8.043622478709436 83.53965 83.53965 30.26749363665582 60.39;41.9329 43.109;31.7336 104.942;62.1373 0 0 Exp 2,2(1) 1.909582233800772 3.8799285888671875 1.5979743003845215 2.281954288482666 0.48364688778009207 1.9399642944335938 33.073492 69.249408 26.273408 48.569192 41.59104400000001 125.48825599999998 UP 1.0 0.0 0.0 GO:0071248 6 cellular response to metal ion 94 103 9 9 9 8 8 8 154 95 2290 0.79515 0.33086 0.53403 7.77 24825;83516;25591;24314;24567;24516;314322;25661 tf;ppargc1a;parp1;nqo1;mt1;jun;fos;fn1 TF_10003;PPARGC1A_33189;PARP1_9425;NQO1_33055;MT1A_9255;JUN_8938;FOS_8657;FN1_8655 36.344437500000154 34.69175 1.28141E-12 28.28837751848593 38.88298089181704 20.916966477661852 23.42645375000016 24.0489 1.28141E-12 18.541254685360148 23.898671452445836 11.601943589628648 68.03711250000016 50.73155 1.28142E-12 61.82308192438966 66.14905505557967 41.4649930580208 4.5 43.78165 45.1539;42.4094;26.9741;87.2765;12.9315;16.4324;1.28141E-12;59.5777 28.132;26.2988;21.799;60.6992;8.91033;10.5224;1.28141E-12;31.0499 61.5341;81.7305;35.2797;197.117;23.4636;39.929;1.28142E-12;105.243 3 5 3 24825;25591;24314 TF_10003;PARP1_9425;NQO1_33055 53.134833333333326 45.1539 30.93325611850997 36.876733333333334 28.132 20.87244980382833 97.97693333333332 61.5341 86.85555822078018 45.1539;26.9741;87.2765 28.132;21.799;60.6992 61.5341;35.2797;197.117 5 83516;24567;24516;314322;25661 PPARGC1A_33189;MT1A_9255;JUN_8938;FOS_8657;FN1_8655 26.270200000000255 16.4324 24.159314805370272 15.356286000000257 10.5224 12.91085256044194 50.073220000000255 39.929 42.90743653309958 42.4094;12.9315;16.4324;1.28141E-12;59.5777 26.2988;8.91033;10.5224;1.28141E-12;31.0499 81.7305;23.4636;39.929;1.28142E-12;105.243 0 Exp 2,3(0.38);Hill,1(0.13);Poly 2,3(0.38);Power,1(0.13) 1.853951960846801 14.905285954475403 1.576730489730835 2.273383855819702 0.20238819404160588 1.8215704560279846 16.74159199935542 55.9472830006449 10.578019768669655 36.274887731330665 25.195902446664498 110.8783225533358 DOWN 0.375 0.625 0.0 GO:0000122 9 negative regulation of transcription by RNA polymerase II 174 180 15 15 11 13 10 10 152 170 2215 0.39609 0.72307 0.75252 5.56 79426;24522;246273;24516;25112;294515;24890;24330;29184;79431 zfp36;zfp354a;trib3;jun;gadd45a;foxo3;esr1;egr1;cd36;bhlhe40 ZFP36_10204;ZFP354A_10203;TRIB3_10079;JUN_8938;GADD45A_8678;FOXO3_8662;ESR1_33192;EGR1_8533;CD36_8243;BHLHE40_8141 37.1882878 19.9148 0.348134 40.949555020775776 41.012407584864754 44.32214621872556 28.4363871 14.415600000000001 0.118102 33.86101798611298 32.888667472697804 37.49050808103105 55.20497700000001 36.34355 1.15962 51.79921733153075 55.67539842285482 52.78658342258225 8.0 102.919 0.348134;0.834827;108.064;16.4324;102.919;13.1992;23.3972;0.750017;48.1296;57.8085 0.118102;0.27095;83.8836;10.5224;89.5012;5.6804;18.3088;0.186019;37.5433;38.3491 1.15962;2.99857;143.428;39.929;115.437;32.7581;31.9156;4.70178;69.1421;110.58 1 9 1 29184 CD36_8243 48.1296 48.1296 37.5433 37.5433 69.1421 69.1421 48.1296 37.5433 69.1421 9 79426;24522;246273;24516;25112;294515;24890;24330;79431 ZFP36_10204;ZFP354A_10203;TRIB3_10079;JUN_8938;GADD45A_8678;FOXO3_8662;ESR1_33192;EGR1_8533;BHLHE40_8141 35.972586444444445 16.4324 43.241734509130346 27.424507888888886 10.5224 35.75431074201701 53.65640777777778 32.7581 54.69529715637254 0.348134;0.834827;108.064;16.4324;102.919;13.1992;23.3972;0.750017;57.8085 0.118102;0.27095;83.8836;10.5224;89.5012;5.6804;18.3088;0.186019;38.3491 1.15962;2.99857;143.428;39.929;115.437;32.7581;31.9156;4.70178;110.58 0 Exp 2,3(0.3);Exp 4,1(0.1);Hill,3(0.3);Poly 2,3(0.3) 2.3447028165698542 25.037078022956848 1.6339634656906128 4.591650485992432 1.053131846732477 1.9834235906600952 11.807490644937126 62.569084955062884 7.449110717303231 49.42366348269677 23.099489474785535 87.31046452521446 DOWN 0.1 0.9 0.0 GO:0006714 7 sesquiterpenoid metabolic process 1 1 1 1 1 1 1 1 161 0 2385 1.0 0.063604 0.063604 100.0 65183 aldh3a2 ALDH3A2_8024 43.1079 43.1079 43.1079 43.1079 31.8774 31.8774 31.8774 31.8774 66.3058 66.3058 66.3058 66.3058 0.0 43.1079 0.0 43.1079 43.1079 31.8774 66.3058 1 0 1 65183 ALDH3A2_8024 43.1079 43.1079 31.8774 31.8774 66.3058 66.3058 43.1079 31.8774 66.3058 0 0 Linear,1(1) 1.520427942276001 1.520427942276001 1.520427942276001 1.520427942276001 0.0 1.520427942276001 43.1079 43.1079 31.8774 31.8774 66.3058 66.3058 UP 1.0 0.0 0.0 GO:0009084 8 glutamine family amino acid biosynthetic process 4 4 2 2 2 2 2 2 160 2 2383 0.99904 0.022157 0.022157 50.0 24957;25698 glul;ass1 GLUL_32832;ASS1_33159 26.6353 26.6353 26.4669 0.23815356390321538 26.65788549149814 0.2360019303896186 21.01405 21.01405 20.9825 0.0446184378940473 21.009818573297114 0.04421532603266343 36.0692 36.0692 35.4303 0.90354104500021 36.15488806720999 0.8953778701059638 0.0 26.4669 0.0 26.4669 26.4669;26.8037 21.0456;20.9825 35.4303;36.7081 0 2 0 2 24957;25698 GLUL_32832;ASS1_33159 26.6353 26.6353 0.23815356390321538 21.01405 21.01405 0.0446184378940473 36.0692 36.0692 0.90354104500021 26.4669;26.8037 21.0456;20.9825 35.4303;36.7081 0 Exp 2,1(0.5);Linear,1(0.5) 2.108183518472531 4.243695855140686 1.8814297914505005 2.3622660636901855 0.3400025887411422 2.121847927570343 26.305236 26.965364 20.952212000000003 21.075888 34.816956000000005 37.321444 DOWN 0.0 1.0 0.0 GO:0043547 7 positive regulation of GTPase activity 63 68 2 2 2 2 2 2 160 66 2319 0.18106 0.93803 0.3187 2.94 25106;24516 rgn;jun RGN_9699;JUN_8938 46.936550000000004 46.936550000000004 16.4324 43.13938263866326 52.654337020547956 42.37475849630658 34.647800000000004 34.647800000000004 10.5224 34.11846787767586 39.16993547945206 33.51373497136601 64.86685 64.86685 39.929 35.26744568642587 69.54127348173516 34.64234771882248 77.4407;16.4324 58.7732;10.5224 89.8047;39.929 1 1 1 25106 RGN_9699 77.4407 77.4407 58.7732 58.7732 89.8047 89.8047 77.4407 58.7732 89.8047 1 24516 JUN_8938 16.4324 16.4324 10.5224 10.5224 39.929 39.929 16.4324 10.5224 39.929 0 Poly 2,2(1) 1.8446695051287265 3.698392391204834 1.7198865413665771 1.9785058498382568 0.18287146676610025 1.849196195602417 -12.851583999999995 106.724684 -12.637983999999996 81.933584 15.988664000000007 113.745036 CONFLICT 0.5 0.5 0.0 GO:0002696 6 positive regulation of leukocyte activation 96 103 5 5 3 5 3 3 159 100 2285 0.096024 0.9656 0.21147 2.91 63868;25423;114851 hspd1;ctsc;cdkn1a HSPD1_8849;CTSC_32456;CDKN1A_8271 34.91539 42.2579 6.24967 25.79064986504411 32.800906160988 27.037482547080167 21.55175 23.9469 2.44025 18.03361490515698 20.316985517211176 18.908052927886303 74.77720000000001 102.383 19.0606 48.252651667240016 69.73416183761059 50.031142390786385 42.2579;56.2386;6.24967 23.9469;38.2681;2.44025 102.383;102.888;19.0606 1 2 1 63868 HSPD1_8849 42.2579 42.2579 23.9469 23.9469 102.383 102.383 42.2579 23.9469 102.383 2 25423;114851 CTSC_32456;CDKN1A_8271 31.244135 31.244135 35.34751138725963 20.354174999999998 20.354174999999998 25.334115690334446 60.9743 60.9743 59.274922989237204 56.2386;6.24967 38.2681;2.44025 102.888;19.0606 0 Exp 2,1(0.34);Exp 3,1(0.34);Exp 4,1(0.34) 1.7537320129766722 5.347596049308777 1.522104263305664 2.2518506050109863 0.4072578626097794 1.5736411809921265 5.7305222613691384 64.10025773863086 1.1447936568893127 41.958706343110684 20.17418439877924 129.38021560122078 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0014074 6 response to purine-containing compound 89 91 21 21 16 20 15 15 147 76 2309 0.99986 4.6221E-4 4.6221E-4 16.48 24825;83516;24651;25513;24516;81678;63868;81869;314322;24330;25146;497840;81718;25698;65054 tf;ppargc1a;pklr;pik3r1;jun;itpr2;hspd1;gstm7;fos;egr1;cyp17a1;cps1;cdo1;ass1;aqp9 TF_10003;PPARGC1A_33189;PKLR_9489;PIK3R1_32562;JUN_8938;ITPR2_8931;HSPD1_8849;GSTM7_8761;FOS_8657;EGR1_8533;CYP17A1_32365;CPS1_32421;CDO1_8275;ASS1_33159;AQP9_32709 28.142167800000088 27.7316 1.28141E-12 15.137243139214762 29.24351347858485 14.43068577376607 19.729301266666752 21.9372 1.28141E-12 10.362752628438363 20.411155239606785 9.60950079853144 47.011178666666765 41.5978 1.28142E-12 27.727923280099844 48.335620526484796 27.42111649439267 3.5 20.8481 8.5 31.89685 45.1539;42.4094;23.0963;18.7324;16.4324;31.8111;42.2579;42.3152;1.28141E-12;0.750017;49.6922;31.9826;22.9638;26.8037;27.7316 28.132;26.2988;17.4625;11.6701;10.5224;24.7342;23.9469;31.4035;1.28141E-12;0.186019;35.6654;24.4836;18.5144;20.9825;21.9372 61.5341;81.7305;32.9443;41.5978;39.929;44.3296;102.383;64.5991;1.28142E-12;4.70178;81.6409;45.5891;30.0179;36.7081;37.4625 4 11 4 24825;63868;81869;25146 TF_10003;HSPD1_8849;GSTM7_8761;CYP17A1_32365 44.8548 43.73455 3.4968251000014687 29.786950000000004 29.76775 4.967039755897495 77.539275 73.12 18.776294942715225 45.1539;42.2579;42.3152;49.6922 28.132;23.9469;31.4035;35.6654 61.5341;102.383;64.5991;81.6409 11 83516;24651;25513;24516;81678;314322;24330;497840;81718;25698;65054 PPARGC1A_33189;PKLR_9489;PIK3R1_32562;JUN_8938;ITPR2_8931;FOS_8657;EGR1_8533;CPS1_32421;CDO1_8275;ASS1_33159;AQP9_32709 22.064847000000114 23.0963 12.836284708835086 16.071974454545572 18.5144 9.368227746138231 35.91005272727285 37.4625 21.50031819615171 42.4094;23.0963;18.7324;16.4324;31.8111;1.28141E-12;0.750017;31.9826;22.9638;26.8037;27.7316 26.2988;17.4625;11.6701;10.5224;24.7342;1.28141E-12;0.186019;24.4836;18.5144;20.9825;21.9372 81.7305;32.9443;41.5978;39.929;44.3296;1.28142E-12;4.70178;45.5891;30.0179;36.7081;37.4625 0 Exp 2,4(0.27);Exp 3,1(0.07);Hill,2(0.14);Linear,5(0.34);Poly 2,3(0.2) 2.0135481547955107 31.168808460235596 1.6674995422363281 4.21828556060791 0.6459406746511869 1.8814297914505005 20.481665830139036 35.80266976986113 14.485024868827725 24.973577664505786 32.97891341507091 61.043443918262604 DOWN 0.26666666666666666 0.7333333333333333 0.0 GO:0098869 4 cellular oxidant detoxification 38 46 5 5 5 5 5 5 157 41 2344 0.93172 0.16478 0.21209 10.87 24314;24464;81869;29328;24360 nqo1;hp;gstm7;gpx4;fabp1 NQO1_33055;HP_8823;GSTM7_8761;GPX4_32827;FABP1_33091 54.85768 45.9204 33.8478 21.395122935075626 50.54751653479321 16.351407699284284 38.88128 34.2198 26.4736 13.37036177322814 35.47437917967581 8.965513858858296 103.1052 70.4292 46.9257 62.56397652151758 91.47867933792396 48.46040415221715 1.5 44.1178 3.5 76.10249999999999 87.2765;64.9285;42.3152;45.9204;33.8478 60.6992;41.6103;31.4035;34.2198;26.4736 197.117;136.455;64.5991;70.4292;46.9257 4 1 4 24314;81869;29328;24360 NQO1_33055;GSTM7_8761;GPX4_32827;FABP1_33091 52.339974999999995 44.1178 23.83434757017347 38.199025 32.81165 15.337936172417944 94.76775 67.51415 68.96072114542208 87.2765;42.3152;45.9204;33.8478 60.6992;31.4035;34.2198;26.4736 197.117;64.5991;70.4292;46.9257 1 24464 HP_8823 64.9285 64.9285 41.6103 41.6103 136.455 136.455 64.9285 41.6103 136.455 0 Exp 2,4(0.8);Linear,1(0.2) 1.6724592004576808 8.38363790512085 1.547789216041565 1.8753424882888794 0.13538985866972625 1.6336230039596558 36.104027886240765 73.61133211375923 27.161641178988532 50.60091882101146 48.26545665763288 157.9449433423671 UP 0.8 0.2 0.0 GO:0016311 6 dephosphorylation 44 50 5 5 4 5 4 4 158 46 2339 0.79064 0.3946 0.55628 8.0 192280;65030;116663;54232 ppp1r3b;ephx2;dusp6;car3 PPP1R3B_9545;EPHX2_33282;DUSP6_8506;CAR3_8196 47.8066 46.34595 36.1411 12.505363326455836 46.36982516968955 11.997915911227532 30.96485 28.85655 27.0588 5.488592935959719 30.024869188828305 4.9017756572949915 80.292125 67.12005 53.6244 36.80942008248932 74.98390777790142 32.88406464230776 1.5 46.34595 36.1411;38.7293;62.3934;53.9626 27.0588;29.2097;39.0875;28.5034 53.6244;57.2113;133.304;77.0288 1 3 1 65030 EPHX2_33282 38.7293 38.7293 29.2097 29.2097 57.2113 57.2113 38.7293 29.2097 57.2113 3 192280;116663;54232 PPP1R3B_9545;DUSP6_8506;CAR3_8196 50.832366666666665 53.9626 13.403155761362104 31.549899999999997 28.5034 6.5675929844959215 87.98573333333333 77.0288 40.9542483155696 36.1411;62.3934;53.9626 27.0588;39.0875;28.5034 53.6244;133.304;77.0288 0 Exp 2,2(0.5);Linear,1(0.25);Poly 2,1(0.25) 2.7334510061559847 12.068865895271301 1.6357084512710571 4.642963409423828 1.4880298757897594 2.895097017288208 35.55134394007328 60.061856059926725 25.586028922759496 36.3436710772405 44.21889331916048 116.36535668083951 DOWN 0.25 0.75 0.0 GO:0032922 6 circadian regulation of gene expression 22 23 3 3 3 3 3 3 159 20 2365 0.94591 0.17665 0.17665 13.04 83516;24330;79431 ppargc1a;egr1;bhlhe40 PPARGC1A_33189;EGR1_8533;BHLHE40_8141 33.65597233333333 42.4094 0.750017 29.519222423735968 25.46065738751088 28.526455449028557 21.611306333333335 26.2988 0.186019 19.508578510732665 16.01261396235857 18.47434308113102 65.67076 81.7305 4.70178 54.735599058042666 50.44504656657964 52.836060924848525 0.5 21.5797085 1.5 50.10895 42.4094;0.750017;57.8085 26.2988;0.186019;38.3491 81.7305;4.70178;110.58 0 3 0 3 83516;24330;79431 PPARGC1A_33189;EGR1_8533;BHLHE40_8141 33.65597233333333 42.4094 29.519222423735968 21.611306333333335 26.2988 19.508578510732665 65.67076 81.7305 54.735599058042666 42.4094;0.750017;57.8085 26.2988;0.186019;38.3491 81.7305;4.70178;110.58 0 Exp 2,2(0.67);Hill,1(0.34) 2.3289140139546225 7.679630279541016 1.7037216424942017 4.21828556060791 1.4364769938903443 1.7576230764389038 0.25182754861302925 67.06011711805363 -0.464728453836436 43.6873411205031 3.7315988131839504 127.60992118681605 DOWN 0.0 1.0 0.0 GO:0098609 4 cell-cell adhesion 84 86 4 4 3 4 3 3 159 83 2302 0.19109 0.92032 0.36822 3.49 307582;361969;29184 lama3;fga;cd36 LAMA3_8980;FGA_8632;CD36_8243 26.393043333333335 28.5803 2.46923 22.908631908707108 33.911323080704825 18.127994150562138 20.314600333333335 22.529 0.871501 18.43591291167596 26.430621153086058 14.429532735596291 39.47023333333333 38.8511 10.4175 29.36719523300333 48.556480724299064 24.509095357172093 2.46923;28.5803;48.1296 0.871501;22.529;37.5433 10.4175;38.8511;69.1421 1 2 1 29184 CD36_8243 48.1296 48.1296 37.5433 37.5433 69.1421 69.1421 48.1296 37.5433 69.1421 2 307582;361969 LAMA3_8980;FGA_8632 15.524765 15.524765 18.463314661036623 11.7002505 11.7002505 15.314164406440874 24.634300000000003 24.634300000000003 20.105591373545813 2.46923;28.5803 0.871501;22.529 10.4175;38.8511 0 Exp 2,1(0.34);Exp 4,1(0.34);Linear,1(0.34) 1.90920733910549 5.9024235010147095 1.541895866394043 2.6703107357025146 0.6131752298307782 1.6902168989181519 0.4694859267874669 52.316600739879206 -0.547599059999385 41.176799726666054 6.23812351002055 72.70234315664612 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0097421 6 liver regeneration 31 34 7 7 6 5 4 4 158 30 2355 0.93913 0.16664 0.27209 11.76 25106;25493;361969;113936 rgn;nfkbia;fga;cpb2 RGN_9699;NFKBIA_9307;FGA_8632;CPB2_8369 33.09318775 27.20595 0.520151 32.14965722147906 41.26768287048104 29.086723778503206 25.474950500000002 21.4832 0.160202 24.383501599585756 31.81756872303414 21.80526090764437 41.5862475 36.827650000000006 2.88499 35.945716915533794 51.482766372404 31.403437410476407 0.5 13.1758755 2.5 53.01050000000001 77.4407;0.520151;28.5803;25.8316 58.7732;0.160202;22.529;20.4374 89.8047;2.88499;38.8511;34.8042 1 3 1 25106 RGN_9699 77.4407 77.4407 58.7732 58.7732 89.8047 89.8047 77.4407 58.7732 89.8047 3 25493;361969;113936 NFKBIA_9307;FGA_8632;CPB2_8369 18.310683666666666 25.8316 15.468229612509004 14.375534000000002 20.4374 12.355178895615714 25.51343 34.8042 19.70099166356101 0.520151;28.5803;25.8316 0.160202;22.529;20.4374 2.88499;38.8511;34.8042 0 Exp 2,1(0.25);Exp 4,1(0.25);Linear,1(0.25);Poly 2,1(0.25) 1.665126843087698 6.679474115371704 1.541895866394043 1.8546061515808105 0.14652576161279005 1.6414860486984253 1.586523672950527 64.59985182704946 1.579118932405958 49.370782067594035 6.359444922776895 76.8130500772231 DOWN 0.25 0.75 0.0 GO:0017038 6 protein import 28 30 5 5 4 5 4 4 158 26 2359 0.96181 0.1192 0.1192 13.33 25513;25493;63868;114851 pik3r1;nfkbia;hspd1;cdkn1a PIK3R1_32562;NFKBIA_9307;HSPD1_8849;CDKN1A_8271 16.94003025 12.491035 0.520151 18.512188371070923 19.14760073617822 18.805714267412345 9.554362999999999 7.055175 0.160202 10.808674433377234 10.51243832907787 11.151838070200638 41.4815975 30.3292 2.88499 43.59431755359894 47.664238953257716 43.886078634670206 0.5 3.3849105 2.0 18.7324 18.7324;0.520151;42.2579;6.24967 11.6701;0.160202;23.9469;2.44025 41.5978;2.88499;102.383;19.0606 1 3 1 63868 HSPD1_8849 42.2579 42.2579 23.9469 23.9469 102.383 102.383 42.2579 23.9469 102.383 3 25513;25493;114851 PIK3R1_32562;NFKBIA_9307;CDKN1A_8271 8.500740333333333 6.24967 9.312464316372456 4.756850666666666 2.44025 6.094621971804432 21.18113 19.0606 19.44332533633843 18.7324;0.520151;6.24967 11.6701;0.160202;2.44025 41.5978;2.88499;19.0606 0 Exp 3,1(0.25);Exp 4,2(0.5);Poly 2,1(0.25) 1.8060116223358995 7.302141070365906 1.522104263305664 2.2518506050109863 0.31504002157812494 1.7640931010246277 -1.2019143536495065 35.081974853649506 -1.038137944709689 20.146863944709686 -1.2408337025269702 84.20402870252697 DOWN 0.25 0.75 0.0 GO:0044089 6 positive regulation of cellular component biogenesis 110 121 5 5 4 5 4 4 158 117 2268 0.10474 0.95682 0.18398 3.31 25513;24890;29184;246142 pik3r1;esr1;cd36;bmf PIK3R1_32562;ESR1_33192;CD36_8243;BMF_8152 46.283975 35.763400000000004 18.7324 34.869055094010896 61.3248769972687 34.3064644305952 35.164100000000005 27.926050000000004 11.6701 27.588996965819543 47.075348907476965 26.987326432855067 63.12587500000001 55.36995 31.9156 34.91270640968937 79.21432408671902 32.283407079770804 18.7324;23.3972;48.1296;94.8767 11.6701;18.3088;37.5433;73.1342 41.5978;31.9156;69.1421;109.848 2 2 2 29184;246142 CD36_8243;BMF_8152 71.50315 71.50315 33.05519141080562 55.338750000000005 55.338750000000005 25.16656673853229 89.49504999999999 89.49504999999999 28.783417924301535 48.1296;94.8767 37.5433;73.1342 69.1421;109.848 2 25513;24890 PIK3R1_32562;ESR1_33192 21.064799999999998 21.064799999999998 3.2985117128790176 14.989450000000001 14.989450000000001 4.694269788263129 36.7567 36.7567 6.846349276804378 18.7324;23.3972 11.6701;18.3088 41.5978;31.9156 0 Exp 2,2(0.5);Poly 2,2(0.5) 2.0746878431953766 8.482054710388184 1.6735800504684448 2.6703107357025146 0.509255660452873 2.069081962108612 12.112301007869327 80.45564899213068 8.126882973496848 62.20131702650316 28.911422718504397 97.3403272814956 CONFLICT 0.5 0.5 0.0 GO:0051384 7 response to glucocorticoid 119 133 27 27 20 25 18 18 144 115 2270 0.99946 0.0014651 0.0015906 13.53 79426;286954;25513;63868;24464;294515;314322;25661;25315;116636;140942;497840;81718;114851;25698;24158;312382;25303 zfp36;ugt2b1;pik3r1;hspd1;hp;foxo3;fos;fn1;ephx1;eif4ebp1;ddit4;cps1;cdo1;cdkn1a;ass1;acadm;abcg2;abcc2 ZFP36_10204;UGT2B10_33303,UGT2B1_33224;PIK3R1_32562;HSPD1_8849;HP_8823;FOXO3_8662;FOS_8657;FN1_8655;EPHX1_8567;EIF4EBP1_8550;DDIT4_8450;CPS1_32421;CDO1_8275;CDKN1A_8271;ASS1_33159;ACADM_7957;ABCG2_32656;ABCC2_32541 32.310877444444515 24.88375 1.28141E-12 27.659708531413273 34.11558441942117 26.114528752847164 20.014874555555625 19.74845 1.28141E-12 16.38005025902492 21.033592856120634 15.195273920284349 62.004331666666744 39.152950000000004 1.28142E-12 61.281880767908525 61.543485881584736 50.261891620920544 5.5 12.83695 12.5 46.852525 0.348134;47.47345;18.7324;42.2579;64.9285;13.1992;1.28141E-12;59.5777;12.4747;83.9001;87.5421;31.9826;22.9638;6.24967;26.8037;11.7137;5.21654;46.2316 0.118102;34.82915;11.6701;23.9469;41.6103;5.6804;1.28141E-12;31.0499;7.00435;42.4185;53.2453;24.4836;18.5144;2.44025;20.9825;8.36151;2.73368;31.1788 1.15962;76.47475;41.5978;102.383;136.455;32.7581;1.28142E-12;105.243;23.684;107.32;245.492;45.5891;30.0179;19.0606;36.7081;18.9642;11.386;81.7848 7 12 6 286954;63868;25315;116636;24158;312382 UGT2B10_33303,UGT2B1_33224;HSPD1_8849;EPHX1_8567;EIF4EBP1_8550;ACADM_7957;ABCG2_32656 33.83939833333333 27.3663 30.093511816675974 19.882348333333336 16.154205 16.373484509043777 56.701991666666665 50.079375 43.835526816503716 47.47345;42.2579;12.4747;83.9001;11.7137;5.21654 34.82915;23.9469;7.00435;42.4185;8.36151;2.73368 76.47475;102.383;23.684;107.32;18.9642;11.386 12 79426;25513;24464;294515;314322;25661;140942;497840;81718;114851;25698;25303 ZFP36_10204;PIK3R1_32562;HP_8823;FOXO3_8662;FOS_8657;FN1_8655;DDIT4_8450;CPS1_32421;CDO1_8275;CDKN1A_8271;ASS1_33159;ABCC2_32541 31.546617000000108 24.88375 27.727384626450743 20.081137666666773 19.74845 17.11084118505901 64.65550166666678 39.152950000000004 70.05333755984157 0.348134;18.7324;64.9285;13.1992;1.28141E-12;59.5777;87.5421;31.9826;22.9638;6.24967;26.8037;46.2316 0.118102;11.6701;41.6103;5.6804;1.28141E-12;31.0499;53.2453;24.4836;18.5144;2.44025;20.9825;31.1788 1.15962;41.5978;136.455;32.7581;1.28142E-12;105.243;245.492;45.5891;30.0179;19.0606;36.7081;81.7848 0 Exp 2,6(0.32);Exp 3,2(0.11);Exp 4,3(0.16);Hill,3(0.16);Linear,2(0.11);Poly 2,2(0.11);Power,1(0.06) 1.8106853273576173 34.660303831100464 1.5074360370635986 2.4453113079071045 0.2363698984978307 1.7792335748672485 19.532744031883453 45.089010857005604 12.447677407524747 27.582071703586518 33.69354714282906 90.31511619050444 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0001547 4 antral ovarian follicle growth 3 3 2 2 2 2 2 2 160 1 2384 0.99975 0.011561 0.011561 66.67 294515;24890 foxo3;esr1 FOXO3_8662;ESR1_33192 18.2982 18.2982 13.1992 7.211074954540402 18.226341788898477 7.210358853413223 11.9946 11.9946 5.6804 8.929627275536197 11.905616450963475 8.92874051230081 32.33685 32.33685 31.9156 0.5957374631500181 32.342786511360366 0.5956783030005348 0.0 13.1992 0.0 13.1992 13.1992;23.3972 5.6804;18.3088 32.7581;31.9156 0 2 0 2 294515;24890 FOXO3_8662;ESR1_33192 18.2982 18.2982 7.211074954540402 11.9946 11.9946 8.929627275536197 32.33685 32.33685 0.5957374631500181 13.1992;23.3972 5.6804;18.3088 32.7581;31.9156 0 Exp 2,1(0.5);Exp 4,1(0.5) 2.201263364875349 4.42532753944397 1.9883413314819336 2.436986207962036 0.3172398345036815 2.212663769721985 8.304160000000001 28.29224 -0.3812319999999989 24.370432 31.511200000000002 33.162499999999994 DOWN 0.0 1.0 0.0 GO:0046321 8 positive regulation of fatty acid oxidation 10 10 2 2 2 2 2 2 160 8 2377 0.97825 0.12934 0.12934 20.0 83516;24360 ppargc1a;fabp1 PPARGC1A_33189;FABP1_33091 38.1286 38.1286 33.8478 6.053965417806771 38.14768463288145 6.053905254757087 26.386200000000002 26.386200000000002 26.2988 0.12360226535111273 26.38581035392594 0.12360103701859178 64.3281 64.3281 46.9257 24.610710097841526 64.40568325903013 24.610465521721395 0.0 33.8478 0.0 33.8478 42.4094;33.8478 26.2988;26.4736 81.7305;46.9257 1 1 1 24360 FABP1_33091 33.8478 33.8478 26.4736 26.4736 46.9257 46.9257 33.8478 26.4736 46.9257 1 83516 PPARGC1A_33189 42.4094 42.4094 26.2988 26.2988 81.7305 81.7305 42.4094 26.2988 81.7305 0 Exp 2,2(1) 1.815528912918461 3.632965564727783 1.7576230764389038 1.8753424882888794 0.08324019439640976 1.8164827823638916 29.738232 46.518968 26.214896 26.557504000000005 30.219396000000003 98.43680400000001 CONFLICT 0.5 0.5 0.0 GO:0006869 6 lipid transport 73 76 18 18 12 17 11 11 151 65 2320 0.99746 0.0075408 0.0075408 14.47 170698;65192;29500;298199;24360;25428;83842;29184;65054;140668;25303 slco1a2;slc27a2;slc10a2;plin2;fabp1;cyp7a1;crot;cd36;aqp9;abcc3;abcc2 SLCO1A2_9886;SLC27A2_9860;SLC10A2_9833;PLIN2_9502;FABP1_33091;CYP7A1_8430;CROT_8384;CD36_8243;AQP9_32709;ABCC3_7941;ABCC2_32541 36.44162454545455 33.8478 5.72128 28.365550749192003 33.670323550041424 22.061010459626758 26.98090936363636 26.4736 0.985273 21.69672783262183 25.09866240026426 16.493833203266192 55.324409090909086 46.9257 10.316 39.76153700186789 51.99463535932636 35.03779238231545 2.5 16.636795 6.5 41.97455 104.197;7.62189;56.585;25.6517;33.8478;5.72128;7.4229;48.1296;27.7316;37.7175;46.2316 80.3101;5.49916;35.2796;20.9252;26.4736;0.985273;5.75707;37.5433;21.9372;30.9007;31.1788 128.412;13.3925;116.8;33.0375;46.9257;22.3625;10.316;69.1421;37.4625;48.9329;81.7848 6 5 6 65192;298199;24360;83842;29184;140668 SLC27A2_9860;PLIN2_9502;FABP1_33091;CROT_8384;CD36_8243;ABCC3_7941 26.731898333333334 29.74975 16.543142390126995 21.183171666666667 23.6994 13.221892239113762 36.95778333333333 39.9816 22.62330144045441 7.62189;25.6517;33.8478;7.4229;48.1296;37.7175 5.49916;20.9252;26.4736;5.75707;37.5433;30.9007 13.3925;33.0375;46.9257;10.316;69.1421;48.9329 5 170698;29500;25428;65054;25303 SLCO1A2_9886;SLC10A2_9833;CYP7A1_8430;AQP9_32709;ABCC2_32541 48.093296 46.2316 36.85507751735275 33.9381946 31.1788 29.110505624246645 77.36436 81.7848 46.89865290307386 104.197;56.585;5.72128;27.7316;46.2316 80.3101;35.2796;0.985273;21.9372;31.1788 128.412;116.8;22.3625;37.4625;81.7848 0 Exp 2,6(0.55);Hill,2(0.19);Linear,1(0.1);Poly 2,2(0.19) 2.4287156970404236 29.396133542060852 1.5806894302368164 5.963563919067383 1.3900594217206101 2.18471097946167 19.678655267142304 53.204593823766785 14.158962583403241 39.80285614386949 31.826842302442184 78.821975879376 CONFLICT 0.5454545454545454 0.45454545454545453 0.0 GO:0050863 7 regulation of T cell activation 94 99 4 4 2 4 2 2 160 97 2288 0.042122 0.98952 0.088811 2.02 63868;246186 hspd1;fgl1 HSPD1_8849;FGL1_8640 28.866799999999998 28.866799999999998 15.4757 18.93787523509436 25.677569823884497 18.392953547147037 17.08035 17.08035 10.2138 9.710768136712979 15.445009477876658 9.431348819675932 66.3968 66.3968 30.4106 50.89217209827067 57.82631102122098 49.427791961701594 42.2579;15.4757 23.9469;10.2138 102.383;30.4106 1 1 1 63868 HSPD1_8849 42.2579 42.2579 23.9469 23.9469 102.383 102.383 42.2579 23.9469 102.383 1 246186 FGL1_8640 15.4757 15.4757 10.2138 10.2138 30.4106 30.4106 15.4757 10.2138 30.4106 0 Exp 3,1(0.5);Poly 2,1(0.5) 1.8447956178295186 3.7631723880767822 1.511321783065796 2.2518506050109863 0.5236329516615296 1.8815861940383911 2.6202439999999996 55.113355999999996 3.621912000000002 30.538787999999997 -4.136151999999996 136.929752 CONFLICT 0.5 0.5 0.0 GO:0006635 7 fatty acid beta-oxidation 29 33 20 20 13 19 12 12 150 21 2364 1.0 3.2327E-7 3.2327E-7 36.36 65192;171155;113965;295143;171142;291075;29740;83842;50681;24158;25287;170465 slc27a2;hadhb;hadh;etfdh;ehhadh;eci2;eci1;crot;acox1;acadm;acadl;acaa2 SLC27A2_9860;HADHB_8777;HADH_8776;ETFDH_8575;EHHADH_8534;ECI2_8521;ECI1_8520;CROT_8384;ACOX1_7973;ACADM_7957;ACADL_32776;ACAA2_7955 18.707056666666666 15.0352 7.4229 10.432465342084194 17.765806656705923 10.425361145613564 14.453845833333334 11.896295 5.49916 8.407907384506839 13.836711995957106 8.209550864178498 25.9237 21.005650000000003 10.316 13.932507216056068 24.67769055370012 14.090659459887442 0.5 7.5223949999999995 2.5 9.637395 7.62189;31.8029;33.3125;18.1231;8.62809;10.6467;11.9473;7.4229;23.1906;11.7137;33.4878;26.5872 5.49916;25.5756;25.7336;14.869;7.31865;8.92359;7.15307;5.75707;16.2815;8.36151;26.6039;21.3695 13.3925;42.1484;46.9856;23.0103;10.3909;13.0581;19.001;10.316;33.4539;18.9642;45.3228;35.0407 12 0 12 65192;171155;113965;295143;171142;291075;29740;83842;50681;24158;25287;170465 SLC27A2_9860;HADHB_8777;HADH_8776;ETFDH_8575;EHHADH_8534;ECI2_8521;ECI1_8520;CROT_8384;ACOX1_7973;ACADM_7957;ACADL_32776;ACAA2_7955 18.707056666666666 15.0352 10.432465342084194 14.453845833333334 11.896295 8.407907384506839 25.9237 21.005650000000003 13.932507216056068 7.62189;31.8029;33.3125;18.1231;8.62809;10.6467;11.9473;7.4229;23.1906;11.7137;33.4878;26.5872 5.49916;25.5756;25.7336;14.869;7.31865;8.92359;7.15307;5.75707;16.2815;8.36151;26.6039;21.3695 13.3925;42.1484;46.9856;23.0103;10.3909;13.0581;19.001;10.316;33.4539;18.9642;45.3228;35.0407 0 0 Exp 2,4(0.34);Hill,2(0.17);Linear,3(0.25);Poly 2,2(0.17);Power,1(0.09) 3.665640755317865 74.43725311756134 1.693061113357544 32.73371124267578 8.933151686672108 2.413228988647461 12.804333726574185 24.60977960675914 9.696624393402194 19.21106727326447 18.04064194415715 33.80675805584285 UP 1.0 0.0 0.0 GO:0018904 4 ether metabolic process 4 4 3 3 3 3 3 3 159 1 2384 0.99998 9.6404E-4 9.6404E-4 75.0 65030;25315;362732 ephx2;ephx1;agmo EPHX2_33282;EPHX1_8567;AGMO_33265 27.579066666666666 31.5332 12.4747 13.566590695651334 26.485250836888742 13.478228984274585 20.253816666666665 24.5474 7.00435 11.708780275324727 19.377724982418307 11.720180636880372 41.5804 43.8459 23.684 16.87807243170856 40.03981724412771 16.511453746260475 0.0 12.4747 0.0 12.4747 38.7293;12.4747;31.5332 29.2097;7.00435;24.5474 57.2113;23.684;43.8459 3 0 3 65030;25315;362732 EPHX2_33282;EPHX1_8567;AGMO_33265 27.579066666666666 31.5332 13.566590695651334 20.253816666666665 24.5474 11.708780275324727 41.5804 43.8459 16.87807243170856 38.7293;12.4747;31.5332 29.2097;7.00435;24.5474 57.2113;23.684;43.8459 0 0 Hill,1(0.34);Linear,2(0.67) 3.020075194381237 9.514459371566772 2.42618465423584 4.642963409423828 1.274372305466129 2.4453113079071045 12.227024078031915 42.931109255301415 7.0040844767384804 33.50354885659485 22.481063062776105 60.67973693722391 UP 1.0 0.0 0.0 GO:0001579 8 medium-chain fatty acid transport 2 2 1 1 1 1 1 1 161 1 2384 0.99598 0.12319 0.12319 50.0 83842 crot CROT_8384 7.4229 7.4229 7.4229 7.4229 5.75707 5.75707 5.75707 5.75707 10.316 10.316 10.316 10.316 0.0 7.4229 0.0 7.4229 7.4229 5.75707 10.316 1 0 1 83842 CROT_8384 7.4229 7.4229 5.75707 5.75707 10.316 10.316 7.4229 5.75707 10.316 0 0 Poly 2,1(1) 5.963563919067383 5.963563919067383 5.963563919067383 5.963563919067383 0.0 5.963563919067383 7.4229 7.4229 5.75707 5.75707 10.316 10.316 UP 1.0 0.0 0.0 GO:0060400 7 negative regulation of growth hormone receptor signaling pathway 1 1 1 1 1 1 1 1 161 0 2385 1.0 0.063604 0.063604 100.0 29455 gdf15 GDF15_33113 105.149 105.149 105.149 105.149 85.3487 85.3487 85.3487 85.3487 125.652 125.652 125.652 125.65200000000002 0.0 105.149 0.0 105.149 105.149 85.3487 125.652 0 1 0 1 29455 GDF15_33113 105.149 105.149 85.3487 85.3487 125.652 125.652 105.149 85.3487 125.652 0 Poly 2,1(1) 1.5606178045272827 1.5606178045272827 1.5606178045272827 1.5606178045272827 0.0 1.5606178045272827 105.149 105.149 85.3487 85.3487 125.652 125.652 DOWN 0.0 1.0 0.0 GO:0051960 6 regulation of nervous system development 221 237 10 10 8 8 7 7 155 230 2155 0.01152 0.99558 0.024202 2.95 24825;25513;24471;294515;25661;25423;79431 tf;pik3r1;hspb1;foxo3;fn1;ctsc;bhlhe40 TF_10003;PIK3R1_32562;HSPB1_8847;FOXO3_8662;FN1_8655;CTSC_32456;BHLHE40_8141 48.54448571428571 56.2386 13.1992 26.016462363500317 55.93324618799158 22.207908829738788 30.496585714285715 31.0499 5.6804 18.202835224439497 34.796203673130336 15.865773476318706 80.10557142857144 102.888 32.7581 33.731386380674905 88.57413847311994 27.625464916352236 45.1539;18.7324;89.1011;13.1992;59.5777;56.2386;57.8085 28.132;11.6701;60.3265;5.6804;31.0499;38.2681;38.3491 61.5341;41.5978;106.138;32.7581;105.243;102.888;110.58 1 6 1 24825 TF_10003 45.1539 45.1539 28.132 28.132 61.5341 61.5341 45.1539 28.132 61.5341 6 25513;24471;294515;25661;25423;79431 PIK3R1_32562;HSPB1_8847;FOXO3_8662;FN1_8655;CTSC_32456;BHLHE40_8141 49.10958333333334 57.02355 28.452507095397863 30.89068333333333 34.659 19.907466529161027 83.20081666666667 104.0655 35.845378372806515 18.7324;89.1011;13.1992;59.5777;56.2386;57.8085 11.6701;60.3265;5.6804;31.0499;38.2681;38.3491 41.5978;106.138;32.7581;105.243;102.888;110.58 0 Exp 2,2(0.29);Exp 4,1(0.15);Poly 2,3(0.43);Power,1(0.15) 1.7457927315589399 12.250306606292725 1.5736411809921265 1.9883413314819336 0.13332674780735893 1.7037216424942017 29.27122068018752 67.8177507483839 17.011736669442733 43.981434759128696 55.117010701176284 105.09413215596656 DOWN 0.14285714285714285 0.8571428571428571 0.0 GO:0044106 5 cellular amine metabolic process 14 16 2 2 2 2 2 2 160 14 2371 0.92323 0.27077 0.27077 12.5 24443;25303 hdc;abcc2 HDC_8788;ABCC2_32541 35.40305 35.40305 24.5745 15.313882270835187 41.355638290879206 12.79251247736646 26.120350000000002 26.120350000000002 21.0619 7.153728594586169 28.90104272801972 5.975895640795301 55.5324 55.5324 29.28 37.12650012484343 69.96367000821692 31.01376957771945 0.0 24.5745 0.5 35.40305 24.5745;46.2316 21.0619;31.1788 29.28;81.7848 1 1 1 24443 HDC_8788 24.5745 24.5745 21.0619 21.0619 29.28 29.28 24.5745 21.0619 29.28 1 25303 ABCC2_32541 46.2316 46.2316 31.1788 31.1788 81.7848 81.7848 46.2316 31.1788 81.7848 0 Exp 2,2(1) 5.705803622911575 19.372031450271606 1.8589661121368408 17.513065338134766 11.069119716070217 9.686015725135803 14.179092000000004 56.627008 16.205788000000005 36.034912 4.077696000000003 106.987104 CONFLICT 0.5 0.5 0.0 GO:0050708 6 regulation of protein secretion 128 139 19 19 14 17 12 12 150 127 2258 0.90034 0.16918 0.28003 8.63 293615;25591;100359982;24539;63868;25675;113965;24957;25661;361969;65210;29184 sirt3;parp1;mpc2;lpl;hspd1;hmgcr;hadh;glul;fn1;fga;cyp2j4;cd36 SIRT3_9828;PARP1_9425;MPC2_33219;LPL_32544;HSPD1_8849;HMGCR_8810;HADH_8776;GLUL_32832;FN1_8655;FGA_8632;CYP2J4_32580;CD36_8243 34.016664166666665 30.9464 1.63089 21.633605432418193 38.83536442335713 20.52777605065274 23.770018916666668 23.237949999999998 0.56209 14.277031015218357 26.848156333943546 12.892308688528175 58.07828916666667 42.918350000000004 7.6286 44.37650879964585 66.23932413456869 45.063194012750465 5.5 30.9464 2.38018;26.9741;46.8463;74.2041;42.2579;1.63089;33.3125;26.4669;59.5777;28.5803;17.8395;48.1296 0.56209;21.799;35.8494;49.8682;23.9469;0.663137;25.7336;21.0456;31.0499;22.529;14.6501;37.5433 8.82917;35.2797;69.127;155.425;102.383;7.6286;46.9856;35.4303;105.243;38.8511;22.6149;69.1421 8 4 8 293615;25591;100359982;24539;63868;113965;65210;29184 SIRT3_9828;PARP1_9425;MPC2_33219;LPL_32544;HSPD1_8849;HADH_8776;CYP2J4_32580;CD36_8243 36.4930225 37.7852 21.746346174959896 26.24407375 24.840249999999997 15.105887855282448 63.72330875 58.05629999999999 47.441381266593915 2.38018;26.9741;46.8463;74.2041;42.2579;33.3125;17.8395;48.1296 0.56209;21.799;35.8494;49.8682;23.9469;25.7336;14.6501;37.5433 8.82917;35.2797;69.127;155.425;102.383;46.9856;22.6149;69.1421 4 25675;24957;25661;361969 HMGCR_8810;GLUL_32832;FN1_8655;FGA_8632 29.063947499999998 27.523600000000002 23.73914001567226 18.821909249999997 21.787300000000002 12.883478952904856 46.78825 37.1407 41.40224375566297 1.63089;26.4669;59.5777;28.5803 0.663137;21.0456;31.0499;22.529 7.6286;35.4303;105.243;38.8511 0 Exp 2,4(0.34);Exp 3,1(0.09);Exp 4,1(0.09);Hill,1(0.09);Linear,4(0.34);Power,1(0.09) 2.0183755823489946 25.090883493423462 1.5209722518920898 3.8079800605773926 0.6431007954935796 1.912074863910675 21.77629960511685 46.25702872821648 15.692028170799015 31.848009662534324 32.96991565151876 83.18666268181457 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0001819 6 positive regulation of cytokine production 132 142 10 10 7 10 7 7 155 135 2250 0.30564 0.81275 0.59585 4.93 25513;24539;63868;24471;24330;65210;29184 pik3r1;lpl;hspd1;hspb1;egr1;cyp2j4;cd36 PIK3R1_32562;LPL_32544;HSPD1_8849;HSPB1_8847;EGR1_8533;CYP2J4_32580;CD36_8243 41.573516714285724 42.2579 0.750017 31.93392928675635 45.2272511819096 31.735077197466346 28.313017000000002 23.9469 0.186019 21.788911987454913 31.161845965868377 21.538477241751323 71.71465428571429 69.1421 4.70178 53.1477347858335 77.24404870115447 55.007126874268415 18.7324;74.2041;42.2579;89.1011;0.750017;17.8395;48.1296 11.6701;49.8682;23.9469;60.3265;0.186019;14.6501;37.5433 41.5978;155.425;102.383;106.138;4.70178;22.6149;69.1421 4 3 4 24539;63868;65210;29184 LPL_32544;HSPD1_8849;CYP2J4_32580;CD36_8243 45.607775000000004 45.19375 23.140211493037384 31.502125 30.7451 15.436759997783433 87.39125 85.76255 55.92361070296398 74.2041;42.2579;17.8395;48.1296 49.8682;23.9469;14.6501;37.5433 155.425;102.383;22.6149;69.1421 3 25513;24471;24330 PIK3R1_32562;HSPB1_8847;EGR1_8533 36.194505666666664 18.7324 46.692315401504736 24.060873 11.6701 31.92753992059186 50.81252666666666 41.5978 51.34208870535104 18.7324;89.1011;0.750017 11.6701;60.3265;0.186019 41.5978;106.138;4.70178 0 Exp 2,2(0.29);Exp 3,1(0.15);Hill,1(0.15);Linear,1(0.15);Poly 2,2(0.29) 2.376292210246464 17.878723740577698 1.559399127960205 4.21828556060791 1.0759034734517614 2.2518506050109863 17.91653083647944 65.230502592092 12.171565111905654 44.45446888809434 32.342261368589284 111.08704720283927 CONFLICT 0.5714285714285714 0.42857142857142855 0.0 GO:1903320 8 regulation of protein modification by small protein conjugation or removal 63 67 4 4 3 4 3 3 159 64 2321 0.37356 0.81097 0.79782 4.48 246273;290556;24330 trib3;gnl3;egr1 TRIB3_10079;GNL3_8735;EGR1_8533 65.483239 87.6357 0.750017 56.98351852157309 47.04853233764318 62.96093875672126 46.159873000000005 54.41 0.186019 42.45432502054397 34.90565277794168 48.00679821860143 129.03092666666666 143.428 4.70178 117.7923452071319 77.07058166088163 103.19627928922206 108.064;87.6357;0.750017 83.8836;54.41;0.186019 143.428;238.963;4.70178 1 2 1 290556 GNL3_8735 87.6357 87.6357 54.41 54.41 238.963 238.963 87.6357 54.41 238.963 2 246273;24330 TRIB3_10079;EGR1_8533 54.407008499999996 54.407008499999996 75.88244509543789 42.0348095 42.0348095 59.18312709401034 74.06489 74.06489 98.09425089037684 108.064;0.750017 83.8836;0.186019 143.428;4.70178 0 Exp 2,1(0.34);Hill,1(0.34);Poly 2,1(0.34) 2.3227067924040834 7.677949786186218 1.582527995109558 4.21828556060791 1.4442409853411062 1.87713623046875 1.000317474707586 129.96616052529242 -1.8817183185948707 94.20146431859487 -4.263660072410602 262.3255134057439 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0048608 4 reproductive structure development 101 108 10 10 8 7 5 5 157 103 2282 0.30424 0.82963 0.54997 4.63 85253;65164;24890;25146;25373 plg;htra1;esr1;cyp17a1;ahsg PLG_9501;HTRA1_8856;ESR1_33192;CYP17A1_32365;AHSG_8003 37.88188 33.1323 12.402 22.93323886190086 43.754677357687235 24.156141345784135 27.225119999999997 25.6145 10.3013 14.152272068717442 30.79101941073785 14.467206438186054 65.24438 46.6629 15.4235 53.59347511103381 79.6147152041555 59.52369488268621 70.7857;33.1323;23.3972;49.6922;12.402 46.2356;25.6145;18.3088;35.6654;10.3013 150.579;46.6629;31.9156;81.6409;15.4235 1 4 1 25146 CYP17A1_32365 49.6922 49.6922 35.6654 35.6654 81.6409 81.6409 49.6922 35.6654 81.6409 4 85253;65164;24890;25373 PLG_9501;HTRA1_8856;ESR1_33192;AHSG_8003 34.9293 28.26475 25.359936945636658 25.11505 21.96165 15.406701039158254 61.145250000000004 39.28925 60.972630370164175 70.7857;33.1323;23.3972;12.402 46.2356;25.6145;18.3088;10.3013 150.579;46.6629;31.9156;15.4235 0 Exp 2,2(0.4);Linear,3(0.6) 2.069988249261973 10.863590717315674 1.5254690647125244 3.431420087814331 0.7933279326417161 1.90940523147583 17.780009832535505 57.9837501674645 14.820106586364275 39.63013341363572 18.267627828503862 112.22113217149615 DOWN 0.2 0.8 0.0 GO:0007612 6 learning 40 43 3 3 3 3 3 3 159 40 2345 0.70906 0.52221 0.75199 6.98 24516;25675;314322 jun;hmgcr;fos JUN_8938;HMGCR_8810;FOS_8657 6.021096666667094 1.63089 1.28141E-12 9.053252364317789 8.484919642706867 9.768078379621219 3.7285123333337604 0.663137 1.28141E-12 5.893014499443519 5.3728954651854135 6.320464859603774 15.852533333333762 7.6286 1.28142E-12 21.196841034770085 21.19807491911705 23.174263251941575 1.5 9.031645000000001 16.4324;1.63089;1.28141E-12 10.5224;0.663137;1.28141E-12 39.929;7.6286;1.28142E-12 0 3 0 3 24516;25675;314322 JUN_8938;HMGCR_8810;FOS_8657 6.021096666667094 1.63089 9.053252364317789 3.7285123333337604 0.663137 5.893014499443519 15.852533333333762 7.6286 21.196841034770085 16.4324;1.63089;1.28141E-12 10.5224;0.663137;1.28141E-12 39.929;7.6286;1.28142E-12 0 Exp 4,1(0.34);Hill,1(0.34);Poly 2,1(0.34) 1.9252874193740925 5.776944160461426 1.8966681957244873 1.9785058498382568 0.04584721770333458 1.9017701148986816 -4.2236228049106685 16.26581613824486 -2.9400613415467225 10.397086008214245 -8.133950346358905 39.83901701302642 DOWN 0.0 1.0 0.0 GO:0045717 8 negative regulation of fatty acid biosynthetic process 10 10 4 4 3 4 3 3 159 7 2378 0.99755 0.021751 0.021751 30.0 246273;25428;25287 trib3;cyp7a1;acadl TRIB3_10079;CYP7A1_8430;ACADL_32776 49.091026666666664 33.4878 5.72128 52.92545319653043 68.46292067919637 51.62255571876362 37.157591000000004 26.6039 0.985273 42.44488720850066 52.875852728321455 40.753846401827055 70.3711 45.3228 22.3625 64.30223030525458 93.20192817887234 64.6658038722035 0.0 5.72128 0.0 5.72128 108.064;5.72128;33.4878 83.8836;0.985273;26.6039 143.428;22.3625;45.3228 1 2 1 25287 ACADL_32776 33.4878 33.4878 26.6039 26.6039 45.3228 45.3228 33.4878 26.6039 45.3228 2 246273;25428 TRIB3_10079;CYP7A1_8430 56.89264 56.89264 72.36723131707609 42.434436500000004 42.434436500000004 58.61796917071986 82.89525 82.89525 85.60623601773996 108.064;5.72128 83.8836;0.985273 143.428;22.3625 0 Exp 2,1(0.34);Hill,1(0.34);Poly 2,1(0.34) 2.527970347594176 8.324691414833069 1.87713623046875 4.560328960418701 1.546237545019335 1.8872262239456177 -10.799761647332915 108.98181498066624 -10.87332042888027 85.18850242888027 -2.393723553414816 143.1359235534148 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0050873 6 brown fat cell differentiation 15 17 3 3 2 3 2 2 160 15 2370 0.91096 0.295 0.295 11.76 246074;83516 scd;ppargc1a SCD1_9787;PPARGC1A_33189 73.93469999999999 73.93469999999999 42.4094 44.583506817880554 68.2921964972234 43.86357701581469 45.025999999999996 45.025999999999996 26.2988 26.48426022527343 41.67414318667236 26.056595162950554 252.21475 252.21475 81.7305 241.10113852100537 221.70090944041007 237.2078625693779 0.0 42.4094 0.5 73.93469999999999 105.46;42.4094 63.7532;26.2988 422.699;81.7305 1 1 1 246074 SCD1_9787 105.46 105.46 63.7532 63.7532 422.699 422.699 105.46 63.7532 422.699 1 83516 PPARGC1A_33189 42.4094 42.4094 26.2988 26.2988 81.7305 81.7305 42.4094 26.2988 81.7305 0 Exp 2,2(1) 1.9827984697220382 3.994444966316223 1.7576230764389038 2.2368218898773193 0.3388447305188509 1.9972224831581116 12.145111999999997 135.724288 8.320687999999997 81.731312 -81.93437999999995 586.36388 CONFLICT 0.5 0.5 0.0 GO:0050767 7 regulation of neurogenesis 202 215 8 8 6 6 5 5 157 210 2175 0.0043011 0.99871 0.0080294 2.33 24825;24471;294515;25661;79431 tf;hspb1;foxo3;fn1;bhlhe40 TF_10003;HSPB1_8847;FOXO3_8662;FN1_8655;BHLHE40_8141 52.96808 57.8085 13.1992 27.456042605262702 60.238564340156785 22.615247445365597 32.70758 31.0499 5.6804 19.67729518981204 36.55311864837398 17.03262912247747 83.25064 105.243 32.7581 34.55247375142624 90.10863163472706 27.257853436604616 45.1539;89.1011;13.1992;59.5777;57.8085 28.132;60.3265;5.6804;31.0499;38.3491 61.5341;106.138;32.7581;105.243;110.58 1 4 1 24825 TF_10003 45.1539 45.1539 28.132 28.132 61.5341 61.5341 45.1539 28.132 61.5341 4 24471;294515;25661;79431 HSPB1_8847;FOXO3_8662;FN1_8655;BHLHE40_8141 54.921625 58.6931 31.299682324412927 33.851475 34.6995 22.52860306756354 88.679775 105.6905 37.354087828096745 89.1011;13.1992;59.5777;57.8085 60.3265;5.6804;31.0499;38.3491 106.138;32.7581;105.243;110.58 0 Exp 2,1(0.2);Exp 4,1(0.2);Poly 2,2(0.4);Power,1(0.2) 1.7975431024235429 9.003085374832153 1.6973176002502441 1.9883413314819336 0.11927202144248891 1.7792335748672485 28.90179755786886 77.03436244213113 15.459670294162258 49.95548970583774 52.964061401205235 113.53721859879477 DOWN 0.2 0.8 0.0 GO:0098660 6 inorganic ion transmembrane transport 90 91 4 4 3 3 2 2 160 89 2296 0.062597 0.98322 0.12276 2.2 29573;81678 slc37a4;itpr2 SLC37A4_9871;ITPR2_8931 35.76385 35.76385 31.8111 5.590032658670267 35.74730277580988 5.589983676518517 23.71265 23.71265 22.6911 1.4446898646422424 23.716926470019963 1.444677205678962 52.1815 52.1815 44.3296 11.104263470397298 52.14862993495202 11.104166170300559 39.7166;31.8111 22.6911;24.7342 60.0334;44.3296 0 2 0 2 29573;81678 SLC37A4_9871;ITPR2_8931 35.76385 35.76385 5.590032658670267 23.71265 23.71265 1.4446898646422424 52.1815 52.1815 11.104263470397298 39.7166;31.8111 22.6911;24.7342 60.0334;44.3296 0 Linear,1(0.5);Poly 2,1(0.5) 1.776950214578446 3.561084508895874 1.6674995422363281 1.893584966659546 0.15986653673709597 1.780542254447937 28.01646 43.51124 21.710411999999998 25.714888000000002 36.791776 67.571224 DOWN 0.0 1.0 0.0 GO:0009804 5 coumarin metabolic process 3 5 1 1 1 1 1 1 161 4 2381 0.9646 0.28025 0.28025 20.0 24894 cyp2a1 CYP2A1_32717 55.3937 55.3937 55.3937 55.3937 38.7444 38.7444 38.7444 38.7444 96.8569 96.8569 96.8569 96.8569 0.0 55.3937 0.0 55.3937 55.3937 38.7444 96.8569 1 0 1 24894 CYP2A1_32717 55.3937 55.3937 38.7444 38.7444 96.8569 96.8569 55.3937 38.7444 96.8569 0 0 Linear,1(1) 1.672747254371643 1.672747254371643 1.672747254371643 1.672747254371643 0.0 1.672747254371643 55.3937 55.3937 38.7444 38.7444 96.8569 96.8569 UP 1.0 0.0 0.0 GO:0042866 8 pyruvate biosynthetic process 2 2 1 1 1 1 1 1 161 1 2384 0.99598 0.12319 0.12319 50.0 24651 pklr PKLR_9489 23.0963 23.0963 23.0963 23.0963 17.4625 17.4625 17.4625 17.4625 32.9443 32.9443 32.9443 32.9443 0.0 23.0963 0.0 23.0963 23.0963 17.4625 32.9443 0 1 0 1 24651 PKLR_9489 23.0963 23.0963 17.4625 17.4625 32.9443 32.9443 23.0963 17.4625 32.9443 0 Exp 2,1(1) 2.6967689990997314 2.6967689990997314 2.6967689990997314 2.6967689990997314 0.0 2.6967689990997314 23.0963 23.0963 17.4625 17.4625 32.9443 32.9443 DOWN 0.0 1.0 0.0 GO:0043535 7 regulation of blood vessel endothelial cell migration 35 37 4 4 4 3 3 3 159 34 2351 0.79406 0.42166 0.508 8.11 85253;24471;25112 plg;hspb1;gadd45a PLG_9501;HSPB1_8847;GADD45A_8678 87.60193333333332 89.1011 70.7857 16.119021922664366 88.21204724113146 16.53361007031197 65.35443333333333 60.3265 46.2356 22.066674444585733 66.60658165828083 22.784980313480023 124.05133333333333 115.437 106.138 23.439404308414737 124.37871400786436 23.082119160871702 0.5 79.9434 70.7857;89.1011;102.919 46.2356;60.3265;89.5012 150.579;106.138;115.437 0 3 0 3 85253;24471;25112 PLG_9501;HSPB1_8847;GADD45A_8678 87.60193333333332 89.1011 16.119021922664366 65.35443333333333 60.3265 22.066674444585733 124.05133333333333 115.437 23.439404308414737 70.7857;89.1011;102.919 46.2356;60.3265;89.5012 150.579;106.138;115.437 0 Linear,1(0.34);Poly 2,2(0.67) 1.6173460558669672 4.856750130653381 1.5254690647125244 1.6973176002502441 0.08690675134481117 1.6339634656906128 69.36154290693082 105.84232375973585 40.383640489158566 90.3252261775081 97.52715041460215 150.57551625206452 DOWN 0.0 1.0 0.0 GO:0009966 5 regulation of signal transduction 594 626 46 46 39 43 36 36 126 590 1795 0.26874 0.79079 0.51015 5.75 308843;246273;24825;293615;297784;25106;83516;29441;25513;25591;25493;24516;25685;192235;65164;24471;25675;81869;29455;299626;25112;289388;294515;25661;361969;24890;29496;24330;116663;140942;65210;25423;29184;246142;25373;170465 tsku;trib3;tf;sirt3;rrs1;rgn;ppargc1a;por;pik3r1;parp1;nfkbia;jun;igfbp1;hyou1;htra1;hspb1;hmgcr;gstm7;gdf15;gadd45b;gadd45a;g0s2;foxo3;fn1;fga;esr1;erbb3;egr1;dusp6;ddit4;cyp2j4;ctsc;cd36;bmf;ahsg;acaa2 TSKU_10094;TRIB3_10079;TF_10003;SIRT3_9828;RRS1_9755;RGN_9699;PPARGC1A_33189;POR_9531;PIK3R1_32562;PARP1_9425;NFKBIA_9307;JUN_8938;IGFBP1_32306;HYOU1_8857;HTRA1_8856;HSPB1_8847;HMGCR_8810;GSTM7_8761;GDF15_33113;GADD45B_8679;GADD45A_8678;G0S2_32729;FOXO3_8662;FN1_8655;FGA_8632;ESR1_33192;ERBB3_8571;EGR1_8533;DUSP6_8506;DDIT4_8450;CYP2J4_32580;CTSC_32456;CD36_8243;BMF_8152;AHSG_8003;ACAA2_7955 45.02921383333334 42.3623 0.520151 33.66404704613475 49.250823261662994 32.378233942170304 31.73146183333333 28.758200000000002 0.160202 24.92351886589184 35.7514708032006 25.38111655062832 70.97841277777778 66.8706 2.88499 50.951853714508026 73.6830865459122 43.29484612257527 30.5 91.9889 1.38416;108.064;45.1539;2.38018;60.39;77.4407;42.4094;12.4414;18.7324;26.9741;0.520151;16.4324;49.0259;40.1982;33.1323;89.1011;1.63089;42.3152;105.149;106.367;102.919;46.3784;13.1992;59.5777;28.5803;23.3972;60.9984;0.750017;62.3934;87.5421;17.8395;56.2386;48.1296;94.8767;12.402;26.5872 0.540568;83.8836;28.132;0.56209;43.109;58.7732;26.2988;8.48981;11.6701;21.799;0.160202;10.5224;32.6883;29.3844;25.6145;60.3265;0.663137;31.4035;85.3487;52.7132;89.5012;33.7914;5.6804;31.0499;22.529;18.3088;41.6036;0.186019;39.0875;53.2453;14.6501;38.2681;37.5433;73.1342;10.3013;21.3695 4.10872;143.428;61.5341;8.82917;104.942;89.8047;81.7305;79.2355;41.5978;35.2797;2.88499;39.929;89.1623;62.3571;46.6629;106.138;7.6286;64.5991;125.652;109.434;115.437;73.6529;32.7581;105.243;38.8511;31.9156;113.972;4.70178;133.304;245.492;22.6149;102.888;69.1421;109.848;15.4235;35.0407 13 23 13 24825;293615;297784;25106;25591;81869;299626;289388;29496;65210;29184;246142;170465 TF_10003;SIRT3_9828;RRS1_9755;RGN_9699;PARP1_9425;GSTM7_8761;GADD45B_8679;G0S2_32729;ERBB3_8571;CYP2J4_32580;CD36_8243;BMF_8152;ACAA2_7955 50.44852923076923 46.3784 29.79080115505637 35.275699230769234 33.7914 19.299596966327424 69.13025923076921 69.1421 35.601459240850545 45.1539;2.38018;60.39;77.4407;26.9741;42.3152;106.367;46.3784;60.9984;17.8395;48.1296;94.8767;26.5872 28.132;0.56209;43.109;58.7732;21.799;31.4035;52.7132;33.7914;41.6036;14.6501;37.5433;73.1342;21.3695 61.5341;8.82917;104.942;89.8047;35.2797;64.5991;109.434;73.6529;113.972;22.6149;69.1421;109.848;35.0407 23 308843;246273;83516;29441;25513;25493;24516;25685;192235;65164;24471;25675;29455;25112;294515;25661;361969;24890;24330;116663;140942;25423;25373 TSKU_10094;TRIB3_10079;PPARGC1A_33189;POR_9531;PIK3R1_32562;NFKBIA_9307;JUN_8938;IGFBP1_32306;HYOU1_8857;HTRA1_8856;HSPB1_8847;HMGCR_8810;GDF15_33113;GADD45A_8678;FOXO3_8662;FN1_8655;FGA_8632;ESR1_33192;EGR1_8533;DUSP6_8506;DDIT4_8450;CTSC_32456;AHSG_8003 41.96612252173912 33.1323 35.9399027020484 29.7281972173913 25.6145 27.811106180002394 72.02302130434784 62.3571 58.6143523386692 1.38416;108.064;42.4094;12.4414;18.7324;0.520151;16.4324;49.0259;40.1982;33.1323;89.1011;1.63089;105.149;102.919;13.1992;59.5777;28.5803;23.3972;0.750017;62.3934;87.5421;56.2386;12.402 0.540568;83.8836;26.2988;8.48981;11.6701;0.160202;10.5224;32.6883;29.3844;25.6145;60.3265;0.663137;85.3487;89.5012;5.6804;31.0499;22.529;18.3088;0.186019;39.0875;53.2453;38.2681;10.3013 4.10872;143.428;81.7305;79.2355;41.5978;2.88499;39.929;89.1623;62.3571;46.6629;106.138;7.6286;125.652;115.437;32.7581;105.243;38.8511;31.9156;4.70178;133.304;245.492;102.888;15.4235 0 Exp 2,11(0.31);Exp 4,3(0.09);Hill,3(0.09);Linear,7(0.2);Poly 2,10(0.28);Power,2(0.06) 2.008404625814738 75.70092129707336 1.5209722518920898 4.21828556060791 0.7298034858967559 1.7939516305923462 34.03229179826263 56.026135868404005 23.589779003808673 39.873144662858 54.33414056437182 87.62268499118373 DOWN 0.3611111111111111 0.6388888888888888 0.0 GO:0034645 5 cellular macromolecule biosynthetic process 143 162 18 18 13 15 10 10 152 152 2233 0.54286 0.58979 1.0 6.17 303612;81819;24516;364070;499914;294515;314322;24890;24330;24158 polg2;pax8;jun;iars2;gins1;foxo3;fos;esr1;egr1;acadm POLG2_9521;PAX8_9432;JUN_8938;IARS2_8858;GINS1_8707;FOXO3_8662;FOS_8657;ESR1_33192;EGR1_8533;ACADM_7957 26.98083170000013 19.9148 1.28141E-12 24.121719739808885 34.21980735073476 26.860742099867334 19.365352900000126 14.415600000000001 1.28141E-12 17.95940404873981 25.246126783933928 20.45748334739572 46.69501800000013 32.7334 1.28142E-12 42.156977126113674 57.06451967557352 44.01078532956924 7.5 57.904799999999994 63.7758;56.8931;16.4324;24.7304;58.9165;13.1992;1.28141E-12;23.3972;0.750017;11.7137 40.9553;45.1162;10.5224;19.8021;44.7208;5.6804;1.28141E-12;18.3088;0.186019;8.36151 132.567;81.5688;39.929;32.7087;91.837;32.7581;1.28142E-12;31.9156;4.70178;18.9642 4 6 4 81819;364070;499914;24158 PAX8_9432;IARS2_8858;GINS1_8707;ACADM_7957 38.063424999999995 40.811749999999996 23.533557322735984 29.5001525 32.261449999999996 18.406733178170384 56.26967499999999 57.13875 35.83247289516175 56.8931;24.7304;58.9165;11.7137 45.1162;19.8021;44.7208;8.36151 81.5688;32.7087;91.837;18.9642 6 303612;24516;294515;314322;24890;24330 POLG2_9521;JUN_8938;FOXO3_8662;FOS_8657;ESR1_33192;EGR1_8533 19.592436166666882 14.8158 23.47937597003289 12.608819833333547 8.1014 15.502755748456908 40.31191333333355 32.33685 48.0246556772107 63.7758;16.4324;13.1992;1.28141E-12;23.3972;0.750017 40.9553;10.5224;5.6804;1.28141E-12;18.3088;0.186019 132.567;39.929;32.7581;1.28142E-12;31.9156;4.70178 0 Exp 2,4(0.4);Exp 4,1(0.1);Hill,2(0.2);Linear,1(0.1);Poly 2,2(0.2) 1.9900434809654786 20.843056797981262 1.5504547357559204 4.21828556060791 0.7924830258703779 1.8268256783485413 12.030034910224245 41.93162848977602 8.233998946199707 30.496706853800546 20.565852870716952 72.8241831292833 DOWN 0.4 0.6 0.0 GO:0060745 6 mammary gland branching involved in pregnancy 1 1 1 1 1 1 1 1 161 0 2385 1.0 0.063604 0.063604 100.0 24890 esr1 ESR1_33192 23.3972 23.3972 23.3972 23.3972 18.3088 18.3088 18.3088 18.3088 31.9156 31.9156 31.9156 31.9156 0.0 23.3972 0.0 23.3972 23.3972 18.3088 31.9156 0 1 0 1 24890 ESR1_33192 23.3972 23.3972 18.3088 18.3088 31.9156 31.9156 23.3972 18.3088 31.9156 0 Exp 2,1(1) 2.436986207962036 2.436986207962036 2.436986207962036 2.436986207962036 0.0 2.436986207962036 23.3972 23.3972 18.3088 18.3088 31.9156 31.9156 DOWN 0.0 1.0 0.0 GO:0060750 6 epithelial cell proliferation involved in mammary gland duct elongation 1 1 1 1 1 1 1 1 161 0 2385 1.0 0.063604 0.063604 100.0 24890 esr1 ESR1_33192 23.3972 23.3972 23.3972 23.3972 18.3088 18.3088 18.3088 18.3088 31.9156 31.9156 31.9156 31.9156 0.0 23.3972 0.0 23.3972 23.3972 18.3088 31.9156 0 1 0 1 24890 ESR1_33192 23.3972 23.3972 18.3088 18.3088 31.9156 31.9156 23.3972 18.3088 31.9156 0 Exp 2,1(1) 2.436986207962036 2.436986207962036 2.436986207962036 2.436986207962036 0.0 2.436986207962036 23.3972 23.3972 18.3088 18.3088 31.9156 31.9156 DOWN 0.0 1.0 0.0 GO:0046620 5 regulation of organ growth 36 37 2 2 2 2 2 2 160 35 2350 0.57834 0.69335 1.0 5.41 29441;116663 por;dusp6 POR_9531;DUSP6_8506 37.4174 37.4174 12.4414 35.32139793383042 34.088033625057584 35.00616790056867 23.788655 23.788655 8.48981 21.635834087643815 21.7492787941041 21.442742502993905 106.26975 106.26975 79.2355 38.23220299858483 102.66601349608476 37.890995137970386 0.5 37.4174 12.4414;62.3934 8.48981;39.0875 79.2355;133.304 0 2 0 2 29441;116663 POR_9531;DUSP6_8506 37.4174 37.4174 35.32139793383042 23.788655 23.788655 21.635834087643815 106.26975 106.26975 38.23220299858483 12.4414;62.3934 8.48981;39.0875 79.2355;133.304 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.8005156371271378 3.617636561393738 1.6357084512710571 1.9819281101226807 0.2448142685540761 1.808818280696869 -11.535559999999997 86.37036 -6.197081199999996 53.7743912 53.28262000000001 159.25688 DOWN 0.0 1.0 0.0 GO:0045039 7 protein insertion into mitochondrial inner membrane 2 2 1 1 1 1 1 1 161 1 2384 0.99598 0.12319 0.12319 50.0 171139 timm9 TIMM9_10020 171139(0.04986) 38.5191 38.5191 38.5191 38.5191 29.55 29.55 29.55 29.55 55.4685 55.4685 55.4685 55.4685 0.0 38.5191 0.0 38.5191 38.5191 29.55 55.4685 1 0 1 171139 TIMM9_10020 38.5191 38.5191 29.55 29.55 55.4685 55.4685 38.5191 29.55 55.4685 0 0 Exp 2,1(1) 1.620712399482727 1.620712399482727 1.620712399482727 1.620712399482727 0.0 1.620712399482727 38.5191 38.5191 29.55 29.55 55.4685 55.4685 UP 1.0 0.0 0.0 GO:0042594 4 response to starvation 75 79 16 16 13 14 11 11 151 68 2317 0.99645 0.010077 0.015192 13.92 79426;83516;24516;24464;24957;294515;116636;497840;114851;246142;24158 zfp36;ppargc1a;jun;hp;glul;foxo3;eif4ebp1;cps1;cdkn1a;bmf;acadm ZFP36_10204;PPARGC1A_33189;JUN_8938;HP_8823;GLUL_32832;FOXO3_8662;EIF4EBP1_8550;CPS1_32421;CDKN1A_8271;BMF_8152;ACADM_7957 35.68248218181818 26.4669 0.348134 32.23889562492389 44.71984665964149 34.89191410084807 23.28306018181818 21.0456 0.118102 22.06605969708495 29.72949022804489 24.831131024024234 57.1131290909091 39.929 1.15962 44.416646569952896 68.97970972558218 46.53103761563882 2.5 12.45645 6.5 37.196 0.348134;42.4094;16.4324;64.9285;26.4669;13.1992;83.9001;31.9826;6.24967;94.8767;11.7137 0.118102;26.2988;10.5224;41.6103;21.0456;5.6804;42.4185;24.4836;2.44025;73.1342;8.36151 1.15962;81.7305;39.929;136.455;35.4303;32.7581;107.32;45.5891;19.0606;109.848;18.9642 3 8 3 116636;246142;24158 EIF4EBP1_8550;BMF_8152;ACADM_7957 63.496833333333335 83.9001 45.18009639490969 41.30473666666667 42.4185 32.40070514712656 78.71073333333334 107.32 51.757452410385596 83.9001;94.8767;11.7137 42.4185;73.1342;8.36151 107.32;109.848;18.9642 8 79426;83516;24516;24464;24957;294515;497840;114851 ZFP36_10204;PPARGC1A_33189;JUN_8938;HP_8823;GLUL_32832;FOXO3_8662;CPS1_32421;CDKN1A_8271 25.252100499999997 21.44965 21.111014066710883 16.5249315 15.783999999999999 14.291743976742886 49.014027500000005 37.67965 42.16732666328677 0.348134;42.4094;16.4324;64.9285;26.4669;13.1992;31.9826;6.24967 0.118102;26.2988;10.5224;41.6103;21.0456;5.6804;24.4836;2.44025 1.15962;81.7305;39.929;136.455;35.4303;32.7581;45.5891;19.0606 0 Exp 2,3(0.28);Exp 3,1(0.1);Exp 4,2(0.19);Hill,1(0.1);Linear,1(0.1);Poly 2,3(0.28) 1.812313402171054 20.074207305908203 1.522104263305664 2.3622660636901855 0.23248860407093416 1.7576230764389038 16.63051235737513 54.734452006261215 10.24285221736767 36.32326814626869 30.864568346183145 83.36168983563505 DOWN 0.2727272727272727 0.7272727272727273 0.0 GO:0006470 7 protein dephosphorylation 27 33 2 2 2 2 2 2 160 31 2354 0.64906 0.63119 1.0 6.06 192280;116663 ppp1r3b;dusp6 PPP1R3B_9545;DUSP6_8506 49.267250000000004 49.267250000000004 36.1411 18.56317935174357 45.25212399291722 17.67340244377111 33.07315 33.07315 27.0588 8.50557533885863 31.233435148295708 8.09788307978309 93.4642 93.4642 53.6244 56.34198548223162 81.27770075254537 53.64138141643609 0.5 49.267250000000004 36.1411;62.3934 27.0588;39.0875 53.6244;133.304 0 2 0 2 192280;116663 PPP1R3B_9545;DUSP6_8506 49.267250000000004 49.267250000000004 18.56317935174357 33.07315 33.07315 8.50557533885863 93.4642 93.4642 56.34198548223162 36.1411;62.3934 27.0588;39.0875 53.6244;133.304 0 Exp 2,2(1) 1.7535581919872332 3.515607237815857 1.6357084512710571 1.8798987865447998 0.17266864197228005 1.7578036189079285 23.53999600000001 74.994504 21.285024000000003 44.86127599999999 15.378192000000013 171.550208 DOWN 0.0 1.0 0.0 GO:0015031 5 protein transport 172 184 13 12 10 12 10 10 152 174 2211 0.36591 0.74855 0.7532 5.43 171139;297784;308821;25513;25493;63868;24471;85255;114851;29184 timm9;rrs1;rab30;pik3r1;nfkbia;hspd1;hspb1;hacl1;cdkn1a;cd36 TIMM9_10020;RRS1_9755;RAB30_9639;PIK3R1_32562;NFKBIA_9307;HSPD1_8849;HSPB1_8847;HACL1_8775;CDKN1A_8271;CD36_8243 171139(0.04986) 34.7947721 32.4697 0.520151 26.79987311319945 38.10871647159646 27.954262361707933 24.095375200000003 22.4797 0.160202 19.0233254992845 26.25915080209269 19.929367203674925 57.462649 48.53315 2.88499 37.07056367997253 61.875054776090266 36.39237667379055 8.5 74.74555000000001 38.5191;60.39;26.4203;18.7324;0.520151;42.2579;89.1011;17.6275;6.24967;48.1296 29.55;43.109;21.0125;11.6701;0.160202;23.9469;60.3265;11.195;2.44025;37.5433 55.4685;104.942;35.3561;41.5978;2.88499;102.383;106.138;37.6534;19.0606;69.1421 6 4 6 171139;297784;308821;63868;85255;29184 TIMM9_10020;RRS1_9755;RAB30_9639;HSPD1_8849;HACL1_8775;CD36_8243 38.89073333333334 40.3885 15.275390970402913 27.726116666666666 26.74845 11.566932906076133 67.49085000000001 62.3053 30.627536218556646 38.5191;60.39;26.4203;42.2579;17.6275;48.1296 29.55;43.109;21.0125;23.9469;11.195;37.5433 55.4685;104.942;35.3561;102.383;37.6534;69.1421 4 25513;25493;24471;114851 PIK3R1_32562;NFKBIA_9307;HSPB1_8847;CDKN1A_8271 28.65083025 12.491035 41.01120768393457 18.649263 7.055175 28.226927328531694 42.420347500000005 30.3292 45.34805442506906 18.7324;0.520151;89.1011;6.24967 11.6701;0.160202;60.3265;2.44025 41.5978;2.88499;106.138;19.0606 0 Exp 2,3(0.3);Exp 3,1(0.1);Exp 4,2(0.2);Linear,1(0.1);Poly 2,3(0.3) 1.9748583025892281 20.235613703727722 1.522104263305664 2.945132255554199 0.4888779511897555 1.786325752735138 18.184038651921313 51.40550554807869 12.30459589929422 35.88615450070578 34.48607558649483 80.43922241350518 UP 0.6 0.4 0.0 GO:0001101 4 response to acid chemical 195 202 30 30 22 27 19 19 143 183 2202 0.97201 0.050241 0.070976 9.41 24522;29482;24648;246074;83516;25513;24314;24539;24471;24464;25661;24330;25146;497840;81718;29184;25698;312382;25303 zfp354a;slc1a2;serpina1;scd;ppargc1a;pik3r1;nqo1;lpl;hspb1;hp;fn1;egr1;cyp17a1;cps1;cdo1;cd36;ass1;abcg2;abcc2 ZFP354A_10203;SLC1A2_33059;SERPINA1_9807;SCD1_9787;PPARGC1A_33189;PIK3R1_32562;NQO1_33055;LPL_32544;HSPB1_8847;HP_8823;FN1_8655;EGR1_8533;CYP17A1_32365;CPS1_32421;CDO1_8275;CD36_8243;ASS1_33159;ABCG2_32656;ABCC2_32541 42.28500442105263 42.4094 0.750017 31.42349028808918 40.49227534738179 30.624209388657228 28.36617731578948 26.2988 0.186019 20.284358741840524 26.861053845845845 19.795540784213358 87.10343421052632 69.1421 2.99857 97.33467740600557 78.1093023246977 83.76074891675668 9.5 44.320499999999996 0.834827;13.3235;15.797;105.46;42.4094;18.7324;87.2765;74.2041;89.1011;64.9285;59.5777;0.750017;49.6922;31.9826;22.9638;48.1296;26.8037;5.21654;46.2316 0.27095;9.10952;13.013;63.7532;26.2988;11.6701;60.6992;49.8682;60.3265;41.6103;31.0499;0.186019;35.6654;24.4836;18.5144;37.5433;20.9825;2.73368;31.1788 2.99857;24.6773;19.9134;422.699;81.7305;41.5978;197.117;155.425;106.138;136.455;105.243;4.70178;81.6409;45.5891;30.0179;69.1421;36.7081;11.386;81.7848 6 13 6 246074;24314;24539;25146;29184;312382 SCD1_9787;NQO1_33055;LPL_32544;CYP17A1_32365;CD36_8243;ABCG2_32656 61.66315666666666 61.94815 35.338827357580314 41.710496666666664 43.70575 22.298433610602935 156.235 118.53295 146.15453677954713 105.46;87.2765;74.2041;49.6922;48.1296;5.21654 63.7532;60.6992;49.8682;35.6654;37.5433;2.73368 422.699;197.117;155.425;81.6409;69.1421;11.386 13 24522;29482;24648;83516;25513;24471;24464;25661;24330;497840;81718;25698;25303 ZFP354A_10203;SLC1A2_33059;SERPINA1_9807;PPARGC1A_33189;PIK3R1_32562;HSPB1_8847;HP_8823;FN1_8655;EGR1_8533;CPS1_32421;CDO1_8275;ASS1_33159;ABCC2_32541 33.34124184615385 26.8037 26.199111777599526 22.207260692307692 20.9825 16.72958609141744 55.19655769230769 41.5978 42.639273980470975 0.834827;13.3235;15.797;42.4094;18.7324;89.1011;64.9285;59.5777;0.750017;31.9826;22.9638;26.8037;46.2316 0.27095;9.10952;13.013;26.2988;11.6701;60.3265;41.6103;31.0499;0.186019;24.4836;18.5144;20.9825;31.1788 2.99857;24.6773;19.9134;81.7305;41.5978;106.138;136.455;105.243;4.70178;45.5891;30.0179;36.7081;81.7848 0 Exp 2,10(0.53);Exp 4,1(0.06);Hill,2(0.11);Linear,2(0.11);Poly 2,3(0.16);Power,1(0.06) 1.9769987371755664 39.71092891693115 1.5074360370635986 4.591650485992432 0.8611708109299279 1.7792335748672485 28.155279974028396 56.414728868076885 19.245217263957414 37.487137367621536 43.336425572146155 130.87044284890652 DOWN 0.3157894736842105 0.6842105263157895 0.0 GO:0032543 7 mitochondrial translation 1 1 1 1 1 1 1 1 161 0 2385 1.0 0.063604 0.063604 100.0 364070 iars2 IARS2_8858 24.7304 24.7304 24.7304 24.7304 19.8021 19.8021 19.8021 19.8021 32.7087 32.7087 32.7087 32.7087 0.0 24.7304 0.0 24.7304 24.7304 19.8021 32.7087 1 0 1 364070 IARS2_8858 24.7304 24.7304 19.8021 19.8021 32.7087 32.7087 24.7304 19.8021 32.7087 0 0 Linear,1(1) 1.7569831609725952 1.7569831609725952 1.7569831609725952 1.7569831609725952 0.0 1.7569831609725952 24.7304 24.7304 19.8021 19.8021 32.7087 32.7087 UP 1.0 0.0 0.0 GO:0032501 2 multicellular organismal process 609 640 62 61 51 55 45 45 117 595 1790 0.81594 0.23679 0.45384 7.03 79426;360268;362895;29573;29482;79224;246074;298490;83516;303612;85253;81819;25591;294103;24539;288001;24516;63868;24471;25675;29328;290556;24384;294515;314322;25661;361969;80841;24360;304929;24890;29496;65030;24330;65210;497840;113936;170945;29184;79431;25373;24158;25287;312382;25303 zfp36;sult1e1;stac3;slc37a4;slc1a2;serpind1;scd;ppcs;ppargc1a;polg2;plg;pax8;parp1;papss2;lpl;kng1;jun;hspd1;hspb1;hmgcr;gpx4;gnl3;gc;foxo3;fos;fn1;fga;fabp7;fabp1;f5;esr1;erbb3;ephx2;egr1;cyp2j4;cps1;cpb2;chrna2;cd36;bhlhe40;ahsg;acadm;acadl;abcg2;abcc2 ZFP36_10204;SULT1E1_32446;STAC3_9953;SLC37A4_9871;SLC1A2_33059;SERPIND1_9812;SCD1_9787;PPCS_9540;PPARGC1A_33189;POLG2_9521;PLG_9501;PAX8_9432;PARP1_9425;PAPSS2_33237;LPL_32544;KNG1L1_34113;JUN_8938;HSPD1_8849;HSPB1_8847;HMGCR_8810;GPX4_32827;GNL3_8735;GC_32893;FOXO3_8662;FOS_8657;FN1_8655;FGA_8632;FABP7_8592;FABP1_33091;F5_33079;ESR1_33192;ERBB3_8571;EPHX2_33282;EGR1_8533;CYP2J4_32580;CPS1_32421;CPB2_8369;CHRNA2_32401;CD36_8243;BHLHE40_8141;AHSG_8003;ACADM_7957;ACADL_32776;ABCG2_32656;ABCC2_32541 37.20843068888891 33.8478 1.28141E-12 25.167227909011988 40.89521990063216 23.918455942157866 25.52235240000003 24.4836 1.28141E-12 16.547985926216974 28.169392308199768 15.852286605591381 70.2772955555556 46.9257 1.28142E-12 72.04908507782159 73.48039891308079 64.01829056698408 31.0 48.1296 0.348134;50.1846;63.2393;39.7166;13.3235;28.261;105.46;20.3353;42.4094;63.7758;70.7857;56.8931;26.9741;34.4443;74.2041;24.3655;16.4324;42.2579;89.1011;1.63089;45.9204;87.6357;42.356;13.1992;1.28141E-12;59.5777;28.5803;24.601;33.8478;10.6089;23.3972;60.9984;38.7293;0.750017;17.8395;31.9826;25.8316;49.3913;48.1296;57.8085;12.402;11.7137;33.4878;5.21654;46.2316 0.118102;36.5009;42.7031;22.6911;9.10952;22.307;63.7532;16.7643;26.2988;40.9553;46.2356;45.1162;21.799;25.719;49.8682;19.538;10.5224;23.9469;60.3265;0.663137;34.2198;54.41;26.3722;5.6804;1.28141E-12;31.0499;22.529;14.4402;26.4736;2.59129;18.3088;41.6036;29.2097;0.186019;14.6501;24.4836;20.4374;41.8524;37.5433;38.3491;10.3013;8.36151;26.6039;2.73368;31.1788 1.15962;80.9788;121.52;60.0334;24.6773;38.3264;422.699;25.6711;81.7305;132.567;150.579;81.5688;35.2797;51.1014;155.425;32.1467;39.929;102.383;106.138;7.6286;70.4292;238.963;78.7583;32.7581;1.28142E-12;105.243;38.8511;35.6155;46.9257;37.5078;31.9156;113.972;57.2113;4.70178;22.6149;45.5891;34.8042;62.472;69.1421;110.58;15.4235;18.9642;45.3228;11.386;81.7848 19 26 19 360268;246074;298490;81819;25591;24539;63868;29328;290556;80841;24360;29496;65030;65210;170945;29184;24158;25287;312382 SULT1E1_32446;SCD1_9787;PPCS_9540;PAX8_9432;PARP1_9425;LPL_32544;HSPD1_8849;GPX4_32827;GNL3_8735;FABP7_8592;FABP1_33091;ERBB3_8571;EPHX2_33282;CYP2J4_32580;CHRNA2_32401;CD36_8243;ACADM_7957;ACADL_32776;ABCG2_32656 43.88527052631579 42.2579 25.645251815709898 31.044762631578948 29.2097 16.19808312294658 89.31705789473685 62.472 97.29400656620527 50.1846;105.46;20.3353;56.8931;26.9741;74.2041;42.2579;45.9204;87.6357;24.601;33.8478;60.9984;38.7293;17.8395;49.3913;48.1296;11.7137;33.4878;5.21654 36.5009;63.7532;16.7643;45.1162;21.799;49.8682;23.9469;34.2198;54.41;14.4402;26.4736;41.6036;29.2097;14.6501;41.8524;37.5433;8.36151;26.6039;2.73368 80.9788;422.699;25.6711;81.5688;35.2797;155.425;102.383;70.4292;238.963;35.6155;46.9257;113.972;57.2113;22.6149;62.472;69.1421;18.9642;45.3228;11.386 26 79426;362895;29573;29482;79224;83516;303612;85253;294103;288001;24516;24471;25675;24384;294515;314322;25661;361969;304929;24890;24330;497840;113936;79431;25373;25303 ZFP36_10204;STAC3_9953;SLC37A4_9871;SLC1A2_33059;SERPIND1_9812;PPARGC1A_33189;POLG2_9521;PLG_9501;PAPSS2_33237;KNG1L1_34113;JUN_8938;HSPB1_8847;HMGCR_8810;GC_32893;FOXO3_8662;FOS_8657;FN1_8655;FGA_8632;F5_33079;ESR1_33192;EGR1_8533;CPS1_32421;CPB2_8369;BHLHE40_8141;AHSG_8003;ABCC2_32541 32.329201576923126 28.420650000000002 24.1370325649528 21.486744923076973 22.418 15.903574613315472 56.363623076923126 39.39005 42.939863269898204 0.348134;63.2393;39.7166;13.3235;28.261;42.4094;63.7758;70.7857;34.4443;24.3655;16.4324;89.1011;1.63089;42.356;13.1992;1.28141E-12;59.5777;28.5803;10.6089;23.3972;0.750017;31.9826;25.8316;57.8085;12.402;46.2316 0.118102;42.7031;22.6911;9.10952;22.307;26.2988;40.9553;46.2356;25.719;19.538;10.5224;60.3265;0.663137;26.3722;5.6804;1.28141E-12;31.0499;22.529;2.59129;18.3088;0.186019;24.4836;20.4374;38.3491;10.3013;31.1788 1.15962;121.52;60.0334;24.6773;38.3264;81.7305;132.567;150.579;51.1014;32.1467;39.929;106.138;7.6286;78.7583;32.7581;1.28142E-12;105.243;38.8511;37.5078;31.9156;4.70178;45.5891;34.8042;110.58;15.4235;81.7848 0 Exp 2,21(0.47);Exp 3,2(0.05);Exp 4,3(0.07);Hill,5(0.12);Linear,8(0.18);Poly 2,5(0.12);Power,1(0.03) 1.979468954731204 92.96851527690887 1.5074360370635986 4.642963409423828 0.7111671043705593 1.8264755010604858 29.85508138734425 44.5617799904336 20.687369334227185 30.357335465772884 49.226026367334086 91.32856474377711 CONFLICT 0.4222222222222222 0.5777777777777777 0.0 GO:0043412 5 macromolecule modification 438 472 25 25 18 22 16 16 146 456 1929 0.0013507 0.99941 0.0023525 3.39 79426;312688;246273;24825;293615;192280;29441;25513;25591;24957;25661;308441;29496;171142;116663;25377 zfp36;usp18;trib3;tf;sirt3;ppp1r3b;por;pik3r1;parp1;glul;fn1;exosc5;erbb3;ehhadh;dusp6;ambp ZFP36_10204;USP18_10138;TRIB3_10079;TF_10003;SIRT3_9828;PPP1R3B_9545;POR_9531;PIK3R1_32562;PARP1_9425;GLUL_32832;FN1_8655;EXOSC5_32543;ERBB3_8571;EHHADH_8534;DUSP6_8506;AMBP_33085 39.771869 31.5576 0.348134 33.46860993327118 40.03301226341123 30.216064261898207 27.55106575 24.4289 0.118102 23.62806665999278 27.02306522733508 20.896177619867927 65.32606812499999 57.57925 1.15962 48.242419442166636 67.6518097296094 45.32277490161 0.348134;108.883;108.064;45.1539;2.38018;36.1411;12.4414;18.7324;26.9741;26.4669;59.5777;41.9329;60.9984;8.62809;62.3934;17.2343 0.118102;73.1414;83.8836;28.132;0.56209;27.0588;8.48981;11.6701;21.799;21.0456;31.0499;31.7336;41.6036;7.31865;39.0875;14.1233 1.15962;138.144;143.428;61.5341;8.82917;53.6244;79.2355;41.5978;35.2797;35.4303;105.243;62.1373;113.972;10.3909;133.304;21.9073 7 9 7 312688;24825;293615;25591;308441;29496;171142 USP18_10138;TF_10003;SIRT3_9828;PARP1_9425;EXOSC5_32543;ERBB3_8571;EHHADH_8534 42.13579571428571 41.9329 35.94739114441726 29.184334285714282 28.132 23.96508616706247 61.46959571428572 61.5341 49.500631192852424 108.883;45.1539;2.38018;26.9741;41.9329;60.9984;8.62809 73.1414;28.132;0.56209;21.799;31.7336;41.6036;7.31865 138.144;61.5341;8.82917;35.2797;62.1373;113.972;10.3909 9 79426;246273;192280;29441;25513;24957;25661;116663;25377 ZFP36_10204;TRIB3_10079;PPP1R3B_9545;POR_9531;PIK3R1_32562;GLUL_32832;FN1_8655;DUSP6_8506;AMBP_33085 37.933259333333325 26.4669 33.50258715068262 26.280745777777778 21.0456 24.736447054682397 68.32554666666667 53.6244 50.02875682255756 0.348134;108.064;36.1411;12.4414;18.7324;26.4669;59.5777;62.3934;17.2343 0.118102;83.8836;27.0588;8.48981;11.6701;21.0456;31.0499;39.0875;14.1233 1.15962;143.428;53.6244;79.2355;41.5978;35.4303;105.243;133.304;21.9073 0 Exp 2,6(0.38);Hill,2(0.13);Linear,2(0.13);Poly 2,4(0.25);Power,2(0.13) 2.133775814221843 59.57290196418762 1.5209722518920898 32.73371124267578 7.7387596615005245 1.7939516305923462 23.372250132697122 56.171487867302886 15.973313086603545 39.128818413396466 41.687282598338356 88.96485365166166 CONFLICT 0.4375 0.5625 0.0 GO:0033233 9 regulation of protein sumoylation 9 9 2 2 2 2 2 2 160 7 2378 0.98404 0.10782 0.10782 22.22 290556;24330 gnl3;egr1 GNL3_8735;EGR1_8533 44.1928585 44.1928585 0.750017 61.437455637324724 14.436536705592543 44.76252430017311 27.2980095 27.2980095 0.186019 38.34214466803051 8.727559549001331 27.935583669919758 121.83239 121.83239 4.70178 165.64769723103367 41.60338096671105 120.68873939608898 0.0 0.750017 0.0 0.750017 87.6357;0.750017 54.41;0.186019 238.963;4.70178 1 1 1 290556 GNL3_8735 87.6357 87.6357 54.41 54.41 238.963 238.963 87.6357 54.41 238.963 1 24330 EGR1_8533 0.750017 0.750017 0.186019 0.186019 4.70178 4.70178 0.750017 0.186019 4.70178 0 Exp 2,1(0.5);Hill,1(0.5) 2.583709540762745 5.800813555717468 1.582527995109558 4.21828556060791 1.8637620481276305 2.900406777858734 -40.95511083999999 129.34082783999997 -25.841491879999992 80.43751087999999 -107.74360559999994 351.4083856 CONFLICT 0.5 0.5 0.0 GO:0046364 5 monosaccharide biosynthetic process 13 16 5 5 2 5 2 2 160 14 2371 0.92323 0.27077 0.27077 12.5 25106;83516 rgn;ppargc1a RGN_9699;PPARGC1A_33189 59.92505 59.92505 42.4094 24.770869783780324 59.403877315548925 24.759902017394264 42.536 42.536 26.2988 22.962868454964436 42.05286719522432 22.952701215018237 85.7676 85.7676 81.7305 5.709321572656501 85.64747735285889 5.706793663633341 0.0 42.4094 0.5 59.92505 77.4407;42.4094 58.7732;26.2988 89.8047;81.7305 1 1 1 25106 RGN_9699 77.4407 77.4407 58.7732 58.7732 89.8047 89.8047 77.4407 58.7732 89.8047 1 83516 PPARGC1A_33189 42.4094 42.4094 26.2988 26.2988 81.7305 81.7305 42.4094 26.2988 81.7305 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.738652430465212 3.477509617805481 1.7198865413665771 1.7576230764389038 0.026683759848126164 1.7387548089027405 25.59437599999999 94.25572400000001 10.711087999999997 74.36091200000001 77.85488400000001 93.68031599999999 CONFLICT 0.5 0.5 0.0 GO:0097305 5 response to alcohol 168 183 27 27 20 26 19 19 143 164 2221 0.98979 0.020403 0.027026 10.38 286954;24648;25513;25591;24314;25493;58954;81678;25675;294515;314322;25661;361969;116636;24330;25428;81718;114851;54232 ugt2b1;serpina1;pik3r1;parp1;nqo1;nfkbia;klf6;itpr2;hmgcr;foxo3;fos;fn1;fga;eif4ebp1;egr1;cyp7a1;cdo1;cdkn1a;car3 UGT2B10_33303,UGT2B1_33224;SERPINA1_9807;PIK3R1_32562;PARP1_9425;NQO1_33055;NFKBIA_9307;KLF6_8969;ITPR2_8931;HMGCR_8810;FOXO3_8662;FOS_8657;FN1_8655;FGA_8632;EIF4EBP1_8550;EGR1_8533;CYP7A1_8430;CDO1_8275;CDKN1A_8271;CAR3_8196 27.58251884210533 18.9476 1.28141E-12 27.089538999602954 32.74596851277227 24.41938834656146 17.451012157894805 13.013 1.28141E-12 16.843071366744727 20.60291782617963 13.730788779364307 47.79566947368427 35.2797 1.28142E-12 48.11642214417443 51.58345295238146 37.27640137989443 8.5 18.84 17.5 85.5883 47.47345;15.797;18.7324;26.9741;87.2765;0.520151;18.9476;31.8111;1.63089;13.1992;1.28141E-12;59.5777;28.5803;83.9001;0.750017;5.72128;22.9638;6.24967;53.9626 34.82915;13.013;11.6701;21.799;60.6992;0.160202;11.6941;24.7342;0.663137;5.6804;1.28141E-12;31.0499;22.529;42.4185;0.186019;0.985273;18.5144;2.44025;28.5034 76.47475;19.9134;41.5978;35.2797;197.117;2.88499;45.5481;44.3296;7.6286;32.7581;1.28142E-12;105.243;38.8511;107.32;4.70178;22.3625;30.0179;19.0606;77.0288 5 15 4 286954;25591;24314;116636 UGT2B10_33303,UGT2B1_33224;PARP1_9425;NQO1_33055;EIF4EBP1_8550 61.4060375 65.686775 29.1829801549172 39.9364625 38.623825 16.251194474631454 104.0478625 91.897375 68.70688452980744 47.47345;26.9741;87.2765;83.9001 34.82915;21.799;60.6992;42.4185 76.47475;35.2797;197.117;107.32 15 24648;25513;25493;58954;81678;25675;294515;314322;25661;361969;24330;25428;81718;114851;54232 SERPINA1_9807;PIK3R1_32562;NFKBIA_9307;KLF6_8969;ITPR2_8931;HMGCR_8810;FOXO3_8662;FOS_8657;FN1_8655;FGA_8632;EGR1_8533;CYP7A1_8430;CDO1_8275;CDKN1A_8271;CAR3_8196 18.562913866666754 15.797 18.62758411475756 11.454892066666751 11.6701 11.188052425442157 32.795084666666746 30.0179 28.63441167106321 15.797;18.7324;0.520151;18.9476;31.8111;1.63089;13.1992;1.28141E-12;59.5777;28.5803;0.750017;5.72128;22.9638;6.24967;53.9626 13.013;11.6701;0.160202;11.6941;24.7342;0.663137;5.6804;1.28141E-12;31.0499;22.529;0.186019;0.985273;18.5144;2.44025;28.5034 19.9134;41.5978;2.88499;45.5481;44.3296;7.6286;32.7581;1.28142E-12;105.243;38.8511;4.70178;22.3625;30.0179;19.0606;77.0288 0 Exp 2,5(0.25);Exp 3,1(0.05);Exp 4,4(0.2);Hill,3(0.15);Linear,3(0.15);Poly 2,3(0.15);Power,1(0.05) 1.981670936398504 42.27423393726349 1.522104263305664 4.560328960418701 0.9286205534284376 1.776119887828827 15.401576561279466 39.763461122931204 9.87744362455227 25.02458069123734 26.159887450718497 69.43145149665006 DOWN 0.21052631578947367 0.7894736842105263 0.0 GO:0051223 7 regulation of protein transport 189 204 22 21 15 19 13 13 149 191 2194 0.57638 0.54208 1.0 6.37 293615;25513;25591;100359982;24539;63868;25675;113965;24957;25661;361969;65210;29184 sirt3;pik3r1;parp1;mpc2;lpl;hspd1;hmgcr;hadh;glul;fn1;fga;cyp2j4;cd36 SIRT3_9828;PIK3R1_32562;PARP1_9425;MPC2_33219;LPL_32544;HSPD1_8849;HMGCR_8810;HADH_8776;GLUL_32832;FN1_8655;FGA_8632;CYP2J4_32580;CD36_8243 32.84095153846153 28.5803 1.63089 21.1419420283946 38.05292883989803 20.458565938346226 22.839255923076923 22.529 0.56209 14.075142514794816 26.25740508386294 12.960274008125227 56.810559230769236 41.5978 7.6286 42.732436527959734 65.28024143872751 44.30245078006547 9.5 47.48795 2.38018;18.7324;26.9741;46.8463;74.2041;42.2579;1.63089;33.3125;26.4669;59.5777;28.5803;17.8395;48.1296 0.56209;11.6701;21.799;35.8494;49.8682;23.9469;0.663137;25.7336;21.0456;31.0499;22.529;14.6501;37.5433 8.82917;41.5978;35.2797;69.127;155.425;102.383;7.6286;46.9856;35.4303;105.243;38.8511;22.6149;69.1421 8 5 8 293615;25591;100359982;24539;63868;113965;65210;29184 SIRT3_9828;PARP1_9425;MPC2_33219;LPL_32544;HSPD1_8849;HADH_8776;CYP2J4_32580;CD36_8243 36.4930225 37.7852 21.746346174959896 26.24407375 24.840249999999997 15.105887855282448 63.72330875 58.05629999999999 47.441381266593915 2.38018;26.9741;46.8463;74.2041;42.2579;33.3125;17.8395;48.1296 0.56209;21.799;35.8494;49.8682;23.9469;25.7336;14.6501;37.5433 8.82917;35.2797;69.127;155.425;102.383;46.9856;22.6149;69.1421 5 25513;25675;24957;25661;361969 PIK3R1_32562;HMGCR_8810;GLUL_32832;FN1_8655;FGA_8632 26.997638000000002 26.4669 21.07150329857174 17.3915474 21.0456 11.606795318137292 45.75016 38.8511 35.93045359083293 18.7324;1.63089;26.4669;59.5777;28.5803 11.6701;0.663137;21.0456;31.0499;22.529 41.5978;7.6286;35.4303;105.243;38.8511 0 Exp 2,4(0.31);Exp 3,1(0.08);Exp 4,1(0.08);Hill,1(0.08);Linear,4(0.31);Poly 2,1(0.08);Power,1(0.08) 1.9894996575156758 26.764463543891907 1.5209722518920898 3.8079800605773926 0.626506827235641 1.9017701148986816 21.3480609345633 44.33384214235978 15.18792129451927 30.490590551634575 33.58094212207264 80.04017633946582 UP 0.6153846153846154 0.38461538461538464 0.0 GO:0048585 5 negative regulation of response to stimulus 377 396 37 37 29 33 27 27 135 369 2016 0.70348 0.37657 0.65503 6.82 79426;308843;293615;85253;25493;24539;288001;192235;65164;24471;25675;81869;29455;294515;361969;80841;24890;29496;24330;116663;140942;65210;113936;114851;246142;25373;170465 zfp36;tsku;sirt3;plg;nfkbia;lpl;kng1;hyou1;htra1;hspb1;hmgcr;gstm7;gdf15;foxo3;fga;fabp7;esr1;erbb3;egr1;dusp6;ddit4;cyp2j4;cpb2;cdkn1a;bmf;ahsg;acaa2 ZFP36_10204;TSKU_10094;SIRT3_9828;PLG_9501;NFKBIA_9307;LPL_32544;KNG1L1_34113;HYOU1_8857;HTRA1_8856;HSPB1_8847;HMGCR_8810;GSTM7_8761;GDF15_33113;FOXO3_8662;FGA_8632;FABP7_8592;ESR1_33192;ERBB3_8571;EGR1_8533;DUSP6_8506;DDIT4_8450;CYP2J4_32580;CPB2_8369;CDKN1A_8271;BMF_8152;AHSG_8003;ACAA2_7955 35.95418155555556 25.8316 0.348134 32.83185348451671 44.01679459455346 34.38713566715373 25.451002518518514 20.4374 0.118102 23.757145087044865 31.672156203132225 25.48104439285229 60.79899555555556 35.0407 1.15962 61.095648308571064 70.43430557884692 56.92345708112325 18.5 51.6568 0.348134;1.38416;2.38018;70.7857;0.520151;74.2041;24.3655;40.1982;33.1323;89.1011;1.63089;42.3152;105.149;13.1992;28.5803;24.601;23.3972;60.9984;0.750017;62.3934;87.5421;17.8395;25.8316;6.24967;94.8767;12.402;26.5872 0.118102;0.540568;0.56209;46.2356;0.160202;49.8682;19.538;29.3844;25.6145;60.3265;0.663137;31.4035;85.3487;5.6804;22.529;14.4402;18.3088;41.6036;0.186019;39.0875;53.2453;14.6501;20.4374;2.44025;73.1342;10.3013;21.3695 1.15962;4.10872;8.82917;150.579;2.88499;155.425;32.1467;62.3571;46.6629;106.138;7.6286;64.5991;125.652;32.7581;38.8511;35.6155;31.9156;113.972;4.70178;133.304;245.492;22.6149;34.8042;19.0606;109.848;15.4235;35.0407 8 19 8 293615;24539;81869;80841;29496;65210;246142;170465 SIRT3_9828;LPL_32544;GSTM7_8761;FABP7_8592;ERBB3_8571;CYP2J4_32580;BMF_8152;ACAA2_7955 42.975285 34.4512 31.351049352619306 30.87892375 26.386499999999998 23.31321131244682 68.24304624999999 50.1073 52.39270639481334 2.38018;74.2041;42.3152;24.601;60.9984;17.8395;94.8767;26.5872 0.56209;49.8682;31.4035;14.4402;41.6036;14.6501;73.1342;21.3695 8.82917;155.425;64.5991;35.6155;113.972;22.6149;109.848;35.0407 19 79426;308843;85253;25493;288001;192235;65164;24471;25675;29455;294515;361969;24890;24330;116663;140942;113936;114851;25373 ZFP36_10204;TSKU_10094;PLG_9501;NFKBIA_9307;KNG1L1_34113;HYOU1_8857;HTRA1_8856;HSPB1_8847;HMGCR_8810;GDF15_33113;FOXO3_8662;FGA_8632;ESR1_33192;EGR1_8533;DUSP6_8506;DDIT4_8450;CPB2_8369;CDKN1A_8271;AHSG_8003 32.99792747368421 24.3655 33.817780613343125 23.165562 19.538 24.19248000458042 57.66465842105263 32.7581 65.49160084936865 0.348134;1.38416;70.7857;0.520151;24.3655;40.1982;33.1323;89.1011;1.63089;105.149;13.1992;28.5803;23.3972;0.750017;62.3934;87.5421;25.8316;6.24967;12.402 0.118102;0.540568;46.2356;0.160202;19.538;29.3844;25.6145;60.3265;0.663137;85.3487;5.6804;22.529;18.3088;0.186019;39.0875;53.2453;20.4374;2.44025;10.3013 1.15962;4.10872;150.579;2.88499;32.1467;62.3571;46.6629;106.138;7.6286;125.652;32.7581;38.8511;31.9156;4.70178;133.304;245.492;34.8042;19.0606;15.4235 0 Exp 2,7(0.26);Exp 4,4(0.15);Hill,5(0.19);Linear,8(0.3);Poly 2,3(0.12) 1.9650807978154348 55.757404923439026 1.5209722518920898 4.21828556060791 0.748692029707922 1.701177716255188 23.56993498333257 48.33842812777853 16.489755699212722 34.41224933782432 37.75358407734032 83.84440703377078 DOWN 0.2962962962962963 0.7037037037037037 0.0 GO:0050810 7 regulation of steroid biosynthetic process 33 36 6 6 6 5 5 5 157 31 2354 0.97612 0.07456 0.07456 13.89 83516;29441;24330;25428;25146 ppargc1a;por;egr1;cyp7a1;cyp17a1 PPARGC1A_33189;POR_9531;EGR1_8533;CYP7A1_8430;CYP17A1_32365 22.2028594 12.4414 0.750017 22.31099014957565 21.038980538465058 21.54487225017641 14.325060400000002 8.48981 0.186019 15.895699898641999 13.676037206795494 14.573196080063884 53.934236 79.2355 4.70178 37.42009727475973 55.80942391061453 39.05881897492562 0.5 3.2356485 2.5 27.4254 42.4094;12.4414;0.750017;5.72128;49.6922 26.2988;8.48981;0.186019;0.985273;35.6654 81.7305;79.2355;4.70178;22.3625;81.6409 1 4 1 25146 CYP17A1_32365 49.6922 49.6922 35.6654 35.6654 81.6409 81.6409 49.6922 35.6654 81.6409 4 83516;29441;24330;25428 PPARGC1A_33189;POR_9531;EGR1_8533;CYP7A1_8430 15.33052425 9.08134 18.677449125789245 8.9899755 4.7375415 12.130271819798448 47.00757 50.799 39.33395769009606 42.4094;12.4414;0.750017;5.72128 26.2988;8.48981;0.186019;0.985273 81.7305;79.2355;4.70178;22.3625 0 Exp 2,1(0.2);Hill,2(0.4);Linear,1(0.2);Poly 2,1(0.2) 2.638814002351365 14.427570939064026 1.7576230764389038 4.560328960418701 1.3804599693792305 1.9819281101226807 2.646414277046496 41.75930452295351 0.3918651148663894 28.258255685133612 21.13407455744119 86.73439744255882 DOWN 0.2 0.8 0.0 GO:0010459 6 negative regulation of heart rate 1 2 1 1 1 1 1 1 161 1 2384 0.99598 0.12319 0.12319 50.0 25513 pik3r1 PIK3R1_32562 18.7324 18.7324 18.7324 18.7324 11.6701 11.6701 11.6701 11.6701 41.5978 41.5978 41.5978 41.5978 0.0 18.7324 0.0 18.7324 18.7324 11.6701 41.5978 0 1 0 1 25513 PIK3R1_32562 18.7324 18.7324 11.6701 11.6701 41.5978 41.5978 18.7324 11.6701 41.5978 0 Poly 2,1(1) 1.6735800504684448 1.6735800504684448 1.6735800504684448 1.6735800504684448 0.0 1.6735800504684448 18.7324 18.7324 11.6701 11.6701 41.5978 41.5978 DOWN 0.0 1.0 0.0 GO:0044249 4 cellular biosynthetic process 372 415 65 65 43 53 33 33 129 382 2003 0.93763 0.092211 0.15289 7.95 65192;246074;25106;298490;303612;24651;25513;81819;294103;100359982;24539;24516;364070;29540;25675;24443;24957;499914;294515;314322;24890;24330;298541;25428;25146;497840;362866;81718;25698;25028;25284;24158;296925 slc27a2;scd;rgn;ppcs;polg2;pklr;pik3r1;pax8;papss2;mpc2;lpl;jun;iars2;hsd17b7;hmgcr;hdc;glul;gins1;foxo3;fos;esr1;egr1;dhdds;cyp7a1;cyp17a1;cps1;chpt1;cdo1;ass1;ampd1;amacr;acadm;aass SLC27A2_9860;SCD1_9787;RGN_9699;PPCS_9540;POLG2_9521;PKLR_9489;PIK3R1_32562;PAX8_9432;PAPSS2_33237;MPC2_33219;LPL_32544;JUN_8938;IARS2_8858;HSD17B7_8834;HMGCR_8810;HDC_8788;GLUL_32832;GINS1_8707;FOXO3_8662;FOS_8657;ESR1_33192;EGR1_8533;DHDDS_8467;CYP7A1_8430;CYP17A1_32365;CPS1_32421;CHPT1_33298;CDO1_8275;ASS1_33159;AMPD1_32743;AMACR_8038;ACADM_7957;AASS_7936 31.006342757575798 24.5745 1.28141E-12 25.772677149200515 35.230806165401404 26.352675372181718 22.511699424242465 19.8021 1.28141E-12 18.206314586065506 25.86407128001268 18.7069276581014 57.19917303030307 35.4303 1.28142E-12 74.93160263071307 62.82732689916247 72.6508907462447 19.5 27.134050000000002 7.62189;105.46;77.4407;20.3353;63.7758;23.0963;18.7324;56.8931;34.4443;46.8463;74.2041;16.4324;24.7304;0.977494;1.63089;24.5745;26.4669;58.9165;13.1992;1.28141E-12;23.3972;0.750017;47.9438;5.72128;49.6922;31.9826;16.0559;22.9638;26.8037;60.9045;2.03774;11.7137;27.4644 5.49916;63.7532;58.7732;16.7643;40.9553;17.4625;11.6701;45.1162;25.719;35.8494;49.8682;10.5224;19.8021;0.322682;0.663137;21.0619;21.0456;44.7208;5.6804;1.28141E-12;18.3088;0.186019;36.5688;0.985273;35.6654;24.4836;10.6021;18.5144;20.9825;50.0633;1.165;8.36151;21.7498 13.3925;422.699;89.8047;25.6711;132.567;32.9443;41.5978;81.5688;51.1014;69.127;155.425;39.929;32.7087;5.49472;7.6286;29.28;35.4303;91.837;32.7581;1.28142E-12;31.9156;4.70178;71.3742;22.3625;81.6409;45.5891;29.905;30.0179;36.7081;82.6625;3.73641;18.9642;37.0295 17 16 17 65192;246074;25106;298490;81819;100359982;24539;364070;24443;499914;298541;25146;362866;25028;25284;24158;296925 SLC27A2_9860;SCD1_9787;RGN_9699;PPCS_9540;PAX8_9432;MPC2_33219;LPL_32544;IARS2_8858;HDC_8788;GINS1_8707;DHDDS_8467;CYP17A1_32365;CHPT1_33298;AMPD1_32743;AMACR_8038;ACADM_7957;AASS_7936 41.93147235294118 46.8463 28.455337675433036 30.90496294117647 35.6654 19.378765727711407 78.63685352941177 69.127 96.70693907589225 7.62189;105.46;77.4407;20.3353;56.8931;46.8463;74.2041;24.7304;24.5745;58.9165;47.9438;49.6922;16.0559;60.9045;2.03774;11.7137;27.4644 5.49916;63.7532;58.7732;16.7643;45.1162;35.8494;49.8682;19.8021;21.0619;44.7208;36.5688;35.6654;10.6021;50.0633;1.165;8.36151;21.7498 13.3925;422.699;89.8047;25.6711;81.5688;69.127;155.425;32.7087;29.28;91.837;71.3742;81.6409;29.905;82.6625;3.73641;18.9642;37.0295 16 303612;24651;25513;294103;24516;29540;25675;24957;294515;314322;24890;24330;25428;497840;81718;25698 POLG2_9521;PKLR_9489;PIK3R1_32562;PAPSS2_33237;JUN_8938;HSD17B7_8834;HMGCR_8810;GLUL_32832;FOXO3_8662;FOS_8657;ESR1_33192;EGR1_8533;CYP7A1_8430;CPS1_32421;CDO1_8275;ASS1_33159 19.398392562500078 20.8481 16.563177302335625 13.593856937500078 14.566299999999998 11.91192137300914 34.42163750000008 32.8512 30.465620861920424 63.7758;23.0963;18.7324;34.4443;16.4324;0.977494;1.63089;26.4669;13.1992;1.28141E-12;23.3972;0.750017;5.72128;31.9826;22.9638;26.8037 40.9553;17.4625;11.6701;25.719;10.5224;0.322682;0.663137;21.0456;5.6804;1.28141E-12;18.3088;0.186019;0.985273;24.4836;18.5144;20.9825 132.567;32.9443;41.5978;51.1014;39.929;5.49472;7.6286;35.4303;32.7581;1.28142E-12;31.9156;4.70178;22.3625;45.5891;30.0179;36.7081 0 Exp 2,15(0.46);Exp 4,4(0.13);Hill,4(0.13);Linear,5(0.16);Poly 2,5(0.16) 2.1110515102864826 83.10872113704681 1.5504547357559204 17.513065338134766 2.773073057915743 1.8966681957244873 22.212906194937627 39.79977932021397 16.299846793443205 28.72355205504172 31.633094254104748 82.76525180650141 CONFLICT 0.5151515151515151 0.48484848484848486 0.0 GO:1903201 6 regulation of oxidative stress-induced cell death 33 36 4 4 3 4 3 3 159 33 2352 0.80746 0.40417 0.49646 8.33 25591;24471;294515 parp1;hspb1;foxo3 PARP1_9425;HSPB1_8847;FOXO3_8662 43.09146666666667 26.9741 13.1992 40.436391247282856 51.68676548677958 39.43807298602175 29.268633333333337 21.799 5.6804 28.078383641216483 36.310588168636535 25.781279899321863 58.058600000000006 35.2797 32.7581 41.65706596617193 64.88210375289387 43.14767609570425 0.5 20.08665 26.9741;89.1011;13.1992 21.799;60.3265;5.6804 35.2797;106.138;32.7581 1 2 1 25591 PARP1_9425 26.9741 26.9741 21.799 21.799 35.2797 35.2797 26.9741 21.799 35.2797 2 24471;294515 HSPB1_8847;FOXO3_8662 51.150150000000004 51.150150000000004 53.67074819494321 33.00345 33.00345 38.640627875398195 69.44805 69.44805 51.88742489279077 89.1011;13.1992 60.3265;5.6804 106.138;32.7581 0 Exp 2,1(0.34);Exp 4,1(0.34);Poly 2,1(0.34) 1.8275577312038045 5.494328618049622 1.6973176002502441 1.9883413314819336 0.1468423186548789 1.8086696863174438 -2.6666176218178776 88.8495509551512 -2.50504887985187 61.04231554651854 10.91919223153004 105.19800776846998 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0033043 6 regulation of organelle organization 271 282 9 9 7 8 6 6 156 276 2109 4.8868E-4 0.99987 0.0010449 2.13 83516;25513;25591;290556;246142;170465 ppargc1a;pik3r1;parp1;gnl3;bmf;acaa2 PPARGC1A_33189;PIK3R1_32562;PARP1_9425;GNL3_8735;BMF_8152;ACAA2_7955 49.53591666666667 34.69175 18.7324 33.294753851345206 48.88520487570893 33.41764170472992 34.78026666666667 24.0489 11.6701 23.70960843166051 36.415796193674 25.59127663744971 90.40995 61.66415000000001 35.0407 78.75138551499268 69.96482197454925 49.262441115724165 42.4094;18.7324;26.9741;87.6357;94.8767;26.5872 26.2988;11.6701;21.799;54.41;73.1342;21.3695 81.7305;41.5978;35.2797;238.963;109.848;35.0407 4 2 4 25591;290556;246142;170465 PARP1_9425;GNL3_8735;BMF_8152;ACAA2_7955 59.018425 57.3049 37.342502300138285 42.678174999999996 38.1045 25.529099445975383 104.78285 72.56385 96.13293529463944 26.9741;87.6357;94.8767;26.5872 21.799;54.41;73.1342;21.3695 35.2797;238.963;109.848;35.0407 2 83516;25513 PPARGC1A_33189;PIK3R1_32562 30.570899999999998 30.570899999999998 16.74216725815389 18.98445 18.98445 10.344052969943654 61.66415000000001 61.66415000000001 28.378104317325356 42.4094;18.7324 26.2988;11.6701 81.7305;41.5978 0 Exp 2,4(0.67);Poly 2,2(0.34) 1.8537639455827377 11.356887936592102 1.582527995109558 2.8333094120025635 0.46710895218124376 1.729400396347046 22.894565037862137 76.1772682954712 15.808628731472403 53.751904601860936 27.395717724013487 153.42418227598654 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0051607 5 defense response to virus 45 46 2 2 2 2 2 2 160 44 2341 0.43116 0.80201 0.76637 4.35 308441;140942 exosc5;ddit4 EXOSC5_32543;DDIT4_8450 64.7375 64.7375 41.9329 32.25057460449351 70.14751176470587 31.329907560212966 42.48945 42.48945 31.7336 15.211068944850657 45.041096380090494 14.776833894543948 153.81465 153.81465 62.1373 129.65135173242504 175.56357530704588 125.95015483127477 41.9329;87.5421 31.7336;53.2453 62.1373;245.492 1 1 1 308441 EXOSC5_32543 41.9329 41.9329 31.7336 31.7336 62.1373 62.1373 41.9329 31.7336 62.1373 1 140942 DDIT4_8450 87.5421 87.5421 53.2453 53.2453 245.492 245.492 87.5421 53.2453 245.492 0 Exp 2,1(0.5);Linear,1(0.5) 1.6322282876821943 3.265190839767456 1.5979743003845215 1.6672165393829346 0.04896165674031751 1.632595419883728 20.040484 109.434516 21.407984 63.570916 -25.87295599999996 333.502256 CONFLICT 0.5 0.5 0.0 GO:0050892 5 intestinal absorption 9 9 4 4 3 3 2 2 160 7 2378 0.98404 0.10782 0.10782 22.22 24360;29184 fabp1;cd36 FABP1_33091;CD36_8243 40.9887 40.9887 33.8478 10.098757627550015 42.692558193584304 9.807070925220794 32.00845 32.00845 26.4736 7.827459935700711 33.32909579013291 7.6013760885123975 58.0339 58.0339 46.9257 15.709367093552805 60.684377892978915 15.255626776952193 0.0 33.8478 0.0 33.8478 33.8478;48.1296 26.4736;37.5433 46.9257;69.1421 2 0 2 24360;29184 FABP1_33091;CD36_8243 40.9887 40.9887 10.098757627550015 32.00845 32.00845 7.827459935700711 58.0339 58.0339 15.709367093552805 33.8478;48.1296 26.4736;37.5433 46.9257;69.1421 0 0 Exp 2,2(1) 2.2377996290099036 4.545653223991394 1.8753424882888794 2.6703107357025146 0.5621274385741666 2.272826611995697 26.992535999999998 54.984864 21.160144000000003 42.856756000000004 36.26182800000001 79.805972 UP 1.0 0.0 0.0 GO:1901021 7 positive regulation of calcium ion transmembrane transporter activity 11 11 3 3 3 3 3 3 159 8 2377 0.99634 0.028536 0.028536 27.27 362895;25106;81869 stac3;rgn;gstm7 STAC3_9953;RGN_9699;GSTM7_8761 60.998400000000004 63.2393 42.3152 17.66964663398792 61.24028115644073 17.514906385540034 44.29326666666666 42.7031 31.4035 13.75396641130601 44.430725884998395 13.663621358438377 91.9746 89.8047 64.5991 28.522422122077995 92.57535299710891 28.530102470087254 0.0 42.3152 0.5 52.777249999999995 63.2393;77.4407;42.3152 42.7031;58.7732;31.4035 121.52;89.8047;64.5991 2 1 2 25106;81869 RGN_9699;GSTM7_8761 59.87795 59.87795 24.837479242568097 45.088350000000005 45.088350000000005 19.353300469041443 77.2019 77.2019 17.823050683875703 77.4407;42.3152 58.7732;31.4035 89.8047;64.5991 1 362895 STAC3_9953 63.2393 63.2393 42.7031 42.7031 121.52 121.52 63.2393 42.7031 121.52 0 Linear,2(0.67);Poly 2,1(0.34) 2.054061243062611 6.34919011592865 1.7198865413665771 2.879150867462158 0.660737802844589 1.7501527070999146 41.00331252838778 80.99348747161223 28.7291884950812 59.85734483825213 59.698440943361234 124.25075905663878 UP 0.6666666666666666 0.3333333333333333 0.0 GO:1901671 7 positive regulation of superoxide dismutase activity 2 3 2 2 2 2 2 2 160 1 2384 0.99975 0.011561 0.011561 66.67 293615;25106 sirt3;rgn SIRT3_9828;RGN_9699 39.91044 39.91044 2.38018 53.075802691388475 40.24533659747817 53.07368952572636 29.667645 29.667645 0.56209 41.161470621396056 29.92736479243453 41.159831814220105 49.316935 49.316935 8.82917 57.25834637317472 49.678222524733265 57.2560666832729 0.0 2.38018 0.0 2.38018 2.38018;77.4407 0.56209;58.7732 8.82917;89.8047 2 0 2 293615;25106 SIRT3_9828;RGN_9699 39.91044 39.91044 53.075802691388475 29.667645 29.667645 41.161470621396056 49.316935 49.316935 57.25834637317472 2.38018;77.4407 0.56209;58.7732 8.82917;89.8047 0 0 Hill,1(0.5);Poly 2,1(0.5) 1.61737432458328 3.240858793258667 1.5209722518920898 1.7198865413665771 0.14065364296231386 1.6204293966293335 -33.6488696 113.46974960000001 -27.379242799999997 86.7145328 -30.0390844 128.67295439999998 UP 1.0 0.0 0.0 GO:1904833 7 positive regulation of removal of superoxide radicals 2 3 2 2 2 2 2 2 160 1 2384 0.99975 0.011561 0.011561 66.67 293615;25106 sirt3;rgn SIRT3_9828;RGN_9699 39.91044 39.91044 2.38018 53.075802691388475 40.24533659747817 53.07368952572636 29.667645 29.667645 0.56209 41.161470621396056 29.92736479243453 41.159831814220105 49.316935 49.316935 8.82917 57.25834637317472 49.678222524733265 57.2560666832729 0.0 2.38018 0.0 2.38018 2.38018;77.4407 0.56209;58.7732 8.82917;89.8047 2 0 2 293615;25106 SIRT3_9828;RGN_9699 39.91044 39.91044 53.075802691388475 29.667645 29.667645 41.161470621396056 49.316935 49.316935 57.25834637317472 2.38018;77.4407 0.56209;58.7732 8.82917;89.8047 0 0 Hill,1(0.5);Poly 2,1(0.5) 1.61737432458328 3.240858793258667 1.5209722518920898 1.7198865413665771 0.14065364296231386 1.6204293966293335 -33.6488696 113.46974960000001 -27.379242799999997 86.7145328 -30.0390844 128.67295439999998 UP 1.0 0.0 0.0 GO:0055114 3 oxidation-reduction process 260 296 71 71 51 61 42 42 120 254 2131 1.0 1.3619E-7 1.6023E-7 14.19 293688;29573;65192;293615;246074;192280;83516;29441;303612;363465;360722;24314;24552;29540;289456;25675;171155;113965;85255;29328;84493;25256;304929;295143;171142;291075;29740;25428;266682;65210;24894;25146;83842;81718;29184;65183;362732;50681;24158;25287;170465;296925 tm7sf2;slc37a4;slc27a2;sirt3;scd;ppp1r3b;ppargc1a;por;polg2;pir;pdia5;nqo1;me1;hsd17b7;hsd17b11;hmgcr;hadhb;hadh;hacl1;gpx4;fmo3;fmo1;f5;etfdh;ehhadh;eci2;eci1;cyp7a1;cyp3a2;cyp2j4;cyp2a1;cyp17a1;crot;cdo1;cd36;aldh3a2;agmo;acox1;acadm;acadl;acaa2;aass TM7SF2_10031;SLC37A4_9871;SLC27A2_9860;SIRT3_9828;SCD1_9787;PPP1R3B_9545;PPARGC1A_33189;POR_9531;POLG2_9521;PIR_9487;PDIA5_9451;NQO1_33055;ME1_9215;HSD17B7_8834;HSD17B11_8832;HMGCR_8810;HADHB_8777;HADH_8776;HACL1_8775;GPX4_32827;FMO3_8654;FMO1_32787;F5_33079;ETFDH_8575;EHHADH_8534;ECI2_8521;ECI1_8520;CYP7A1_8430;CYP3A2_32374;CYP2J4_32580;CYP2A1_32717;CYP17A1_32365;CROT_8384;CDO1_8275;CD36_8243;ALDH3A2_8024;AGMO_33265;ACOX1_7973;ACADM_7957;ACADL_32776;ACAA2_7955;AASS_7936 35.150472 29.498800000000003 0.977494 28.014464153564877 33.278248605924986 23.434711881560812 24.193309333333335 22.22045 0.322682 18.155533113391424 23.395614634447536 15.139232164739546 64.83396166666668 42.997150000000005 5.49472 73.35269369489748 59.72493623980237 64.17506986998431 13.5 17.7335 28.5 44.51415 82.3097;39.7166;7.62189;2.38018;105.46;36.1411;42.4094;12.4414;63.7758;50.0307;107.066;87.2765;80.7944;0.977494;22.4334;1.63089;31.8029;33.3125;17.6275;45.9204;62.8595;65.2792;10.6089;18.1231;8.62809;10.6467;11.9473;5.72128;12.8505;17.8395;55.3937;49.6922;7.4229;22.9638;48.1296;43.1079;31.5332;23.1906;11.7137;33.4878;26.5872;27.4644 51.1696;22.6911;5.49916;0.56209;63.7532;27.0588;26.2988;8.48981;40.9553;38.7717;61.3361;60.6992;59.856;0.322682;18.1233;0.663137;25.5756;25.7336;11.195;34.2198;42.5185;39.7882;2.59129;14.869;7.31865;8.92359;7.15307;0.985273;7.33176;14.6501;38.7444;35.6654;5.75707;18.5144;37.5433;31.8774;24.5474;16.2815;8.36151;26.6039;21.3695;21.7498 209.842;60.0334;13.3925;8.82917;422.699;53.6244;81.7305;79.2355;132.567;73.0083;114.259;197.117;94.0621;5.49472;29.2247;7.6286;42.1484;46.9856;37.6534;70.4292;120.21;82.9415;37.5078;23.0103;10.3909;13.0581;19.001;22.3625;24.0283;22.6149;96.8569;81.6409;10.316;30.0179;69.1421;66.3058;43.8459;33.4539;18.9642;45.3228;35.0407;37.0295 28 14 28 65192;293615;246074;363465;24314;289456;171155;113965;85255;29328;25256;295143;171142;291075;29740;266682;65210;24894;25146;83842;29184;65183;362732;50681;24158;25287;170465;296925 SLC27A2_9860;SIRT3_9828;SCD1_9787;PIR_9487;NQO1_33055;HSD17B11_8832;HADHB_8777;HADH_8776;HACL1_8775;GPX4_32827;FMO1_32787;ETFDH_8575;EHHADH_8534;ECI2_8521;ECI1_8520;CYP3A2_32374;CYP2J4_32580;CYP2A1_32717;CYP17A1_32365;CROT_8384;CD36_8243;ALDH3A2_8024;AGMO_33265;ACOX1_7973;ACADM_7957;ACADL_32776;ACAA2_7955;AASS_7936 32.38941285714286 27.0258 24.64480807672313 23.30957857142857 21.559649999999998 16.186749184931696 59.80182035714286 37.341449999999995 80.90224508188773 7.62189;2.38018;105.46;50.0307;87.2765;22.4334;31.8029;33.3125;17.6275;45.9204;65.2792;18.1231;8.62809;10.6467;11.9473;12.8505;17.8395;55.3937;49.6922;7.4229;48.1296;43.1079;31.5332;23.1906;11.7137;33.4878;26.5872;27.4644 5.49916;0.56209;63.7532;38.7717;60.6992;18.1233;25.5756;25.7336;11.195;34.2198;39.7882;14.869;7.31865;8.92359;7.15307;7.33176;14.6501;38.7444;35.6654;5.75707;37.5433;31.8774;24.5474;16.2815;8.36151;26.6039;21.3695;21.7498 13.3925;8.82917;422.699;73.0083;197.117;29.2247;42.1484;46.9856;37.6534;70.4292;82.9415;23.0103;10.3909;13.0581;19.001;24.0283;22.6149;96.8569;81.6409;10.316;69.1421;66.3058;43.8459;33.4539;18.9642;45.3228;35.0407;37.0295 14 293688;29573;192280;83516;29441;303612;360722;24552;29540;25675;84493;304929;25428;81718 TM7SF2_10031;SLC37A4_9871;PPP1R3B_9545;PPARGC1A_33189;POR_9531;POLG2_9521;PDIA5_9451;ME1_9215;HSD17B7_8834;HMGCR_8810;FMO3_8654;F5_33079;CYP7A1_8430;CDO1_8275 40.672590285714286 37.92885 34.12415275695097 25.960770857142855 24.49495 22.14404492815087 74.8982442857143 69.63445 56.67624728769876 82.3097;39.7166;36.1411;42.4094;12.4414;63.7758;107.066;80.7944;0.977494;1.63089;62.8595;10.6089;5.72128;22.9638 51.1696;22.6911;27.0588;26.2988;8.48981;40.9553;61.3361;59.856;0.322682;0.663137;42.5185;2.59129;0.985273;18.5144 209.842;60.0334;53.6244;81.7305;79.2355;132.567;114.259;94.0621;5.49472;7.6286;120.21;37.5078;22.3625;30.0179 0 Exp 2,12(0.29);Exp 3,1(0.03);Exp 4,2(0.05);Hill,6(0.15);Linear,13(0.31);Poly 2,7(0.17);Power,1(0.03) 2.359742783963167 136.19288420677185 1.520427942276001 32.73371124267578 5.033645813919497 1.9055876731872559 26.67792969407551 43.623014305924464 18.702448557035122 29.68417010963155 42.64957158956952 87.01835174376384 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0072330 7 monocarboxylic acid biosynthetic process 51 55 11 11 8 9 6 6 156 49 2336 0.9432 0.13326 0.15913 10.91 65192;246074;24651;24539;25428;25284 slc27a2;scd;pklr;lpl;cyp7a1;amacr SLC27A2_9860;SCD1_9787;PKLR_9489;LPL_32544;CYP7A1_8430;AMACR_8038 36.356885 15.359095 2.03774 43.186894413464714 40.87665580448331 41.22261791610154 23.122222166666663 11.48083 0.985273 27.132978416576318 26.863352212581987 25.97848543897849 108.42661833333334 27.653399999999998 3.73641 163.75110013154972 108.17982986556598 146.70928567468272 1.5 6.671585 4.5 89.83205 7.62189;105.46;23.0963;74.2041;5.72128;2.03774 5.49916;63.7532;17.4625;49.8682;0.985273;1.165 13.3925;422.699;32.9443;155.425;22.3625;3.73641 4 2 4 65192;246074;24539;25284 SLC27A2_9860;SCD1_9787;LPL_32544;AMACR_8038 47.3309325 40.912994999999995 50.75902863206201 30.07139 27.683680000000003 31.441755045677713 148.8132275 84.40875000000001 195.31443736197204 7.62189;105.46;74.2041;2.03774 5.49916;63.7532;49.8682;1.165 13.3925;422.699;155.425;3.73641 2 24651;25428 PKLR_9489;CYP7A1_8430 14.40879 14.40879 12.285994465251887 9.223886499999999 9.223886499999999 11.651158946850073 27.653399999999998 27.653399999999998 7.482462537159829 23.0963;5.72128 17.4625;0.985273 32.9443;22.3625 0 Exp 2,3(0.5);Exp 4,1(0.17);Hill,2(0.34) 2.2957588447065413 14.80022406578064 1.559399127960205 4.560328960418701 1.11444169885164 2.2107664346694946 1.8001724031089523 70.91359759689104 1.4113177412967275 44.83312659203661 -22.6015507796194 239.4547874462861 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0009617 5 response to bacterium 110 127 14 14 11 13 10 10 152 117 2268 0.81984 0.28586 0.45429 7.87 312688;25357;24825;29500;246074;24539;24464;361969;29184;54232 usp18;thrsp;tf;slc10a2;scd;lpl;hp;fga;cd36;car3 USP18_10138;THRSP_33314;TF_10003;SLC10A2_9833;SCD1_9787;LPL_32544;HP_8823;FGA_8632;CD36_8243;CAR3_8196 61.80923 55.2738 28.5803 27.525021197773647 57.51304935894461 23.85283576049522 40.475699999999996 36.41145 22.529 17.030427527092687 38.01097528109003 14.676740844970379 126.26859000000002 96.9144 38.8511 112.01284253911292 111.07720205075859 93.13991902318993 5.5 60.75675 108.883;32.2053;45.1539;56.585;105.46;74.2041;64.9285;28.5803;48.1296;53.9626 73.1414;24.3966;28.132;35.2796;63.7532;49.8682;41.6103;22.529;37.5433;28.5034 138.144;46.6068;61.5341;116.8;422.699;155.425;136.455;38.8511;69.1421;77.0288 5 5 5 312688;24825;246074;24539;29184 USP18_10138;TF_10003;SCD1_9787;LPL_32544;CD36_8243 76.36612 74.2041 30.331416913441455 50.48762000000001 49.8682 18.417941035903002 169.38884000000002 138.144 147.49518622186622 108.883;45.1539;105.46;74.2041;48.1296 73.1414;28.132;63.7532;49.8682;37.5433 138.144;61.5341;422.699;155.425;69.1421 5 25357;29500;24464;361969;54232 THRSP_33314;SLC10A2_9833;HP_8823;FGA_8632;CAR3_8196 47.252340000000004 53.9626 15.965832696824792 30.463780000000003 28.5034 7.922302804866769 83.14834 77.0288 42.74638174194393 32.2053;56.585;64.9285;28.5803;53.9626 24.3966;35.2796;41.6103;22.529;28.5034 46.6068;116.8;136.455;38.8511;77.0288 0 Exp 2,6(0.6);Linear,1(0.1);Poly 2,2(0.2);Power,1(0.1) 2.04906087419797 21.535778522491455 1.541895866394043 3.910295248031616 0.7781646855936695 1.7699049711227417 44.74904511264138 78.86941488735862 29.920131659639814 51.03126834036018 56.84231091577455 195.69486908422545 CONFLICT 0.5 0.5 0.0 GO:0030335 7 positive regulation of cell migration 186 194 10 10 10 7 7 7 155 187 2198 0.06181 0.97118 0.12428 3.61 85253;25513;24516;24471;25661;361969;24330 plg;pik3r1;jun;hspb1;fn1;fga;egr1 PLG_9501;PIK3R1_32562;JUN_8938;HSPB1_8847;FN1_8655;FGA_8632;EGR1_8533 40.56565957142857 28.5803 0.750017 32.7068728272949 45.73715094882484 31.808587214970224 26.074217 22.529 0.186019 21.356352038354377 29.18349814129533 20.534001410025674 69.57709714285714 41.5978 4.70178 51.615257625422394 77.11025441157078 52.64381249567813 70.7857;18.7324;16.4324;89.1011;59.5777;28.5803;0.750017 46.2356;11.6701;10.5224;60.3265;31.0499;22.529;0.186019 150.579;41.5978;39.929;106.138;105.243;38.8511;4.70178 0 7 0 7 85253;25513;24516;24471;25661;361969;24330 PLG_9501;PIK3R1_32562;JUN_8938;HSPB1_8847;FN1_8655;FGA_8632;EGR1_8533 40.56565957142857 28.5803 32.7068728272949 26.074217 22.529 21.356352038354377 69.57709714285714 41.5978 51.615257625422394 70.7857;18.7324;16.4324;89.1011;59.5777;28.5803;0.750017 46.2356;11.6701;10.5224;60.3265;31.0499;22.529;0.186019 150.579;41.5978;39.929;106.138;105.243;38.8511;4.70178 0 Hill,1(0.15);Linear,2(0.29);Poly 2,3(0.43);Power,1(0.15) 1.9285233649332165 14.414287567138672 1.5254690647125244 4.21828556060791 0.9642507536895896 1.6973176002502441 16.33606910560984 64.7952500372473 10.253210006590752 41.895223993409246 31.339979193505734 107.81421509220854 DOWN 0.0 1.0 0.0 GO:1904037 9 positive regulation of epithelial cell apoptotic process 14 16 2 2 2 2 2 2 160 14 2371 0.92323 0.27077 0.27077 12.5 83516;294515 ppargc1a;foxo3 PPARGC1A_33189;FOXO3_8662 27.804299999999998 27.804299999999998 13.1992 20.65473049981529 35.33847008101057 17.694362220798183 15.9896 15.9896 5.6804 14.579410457216714 21.3076920499794 12.489795962140134 57.2443 57.2443 32.7581 34.62871613098009 69.87572295757244 29.665506721002135 0.0 13.1992 0.5 27.804299999999998 42.4094;13.1992 26.2988;5.6804 81.7305;32.7581 0 2 0 2 83516;294515 PPARGC1A_33189;FOXO3_8662 27.804299999999998 27.804299999999998 20.65473049981529 15.9896 15.9896 14.579410457216714 57.2443 57.2443 34.62871613098009 42.4094;13.1992 26.2988;5.6804 81.7305;32.7581 0 Exp 2,1(0.5);Exp 4,1(0.5) 1.8694262777788009 3.7459644079208374 1.7576230764389038 1.9883413314819336 0.16314244268445371 1.8729822039604187 -0.8216959999999993 56.430296 -4.2164319999999975 36.195631999999996 9.251347999999993 105.23725200000001 DOWN 0.0 1.0 0.0 GO:0050427 8 3'-phosphoadenosine 5'-phosphosulfate metabolic process 4 5 2 2 2 2 2 2 160 3 2382 0.9977 0.035397 0.035397 40.0 360268;294103 sult1e1;papss2 SULT1E1_32446;PAPSS2_33237 42.31445 42.31445 34.4443 11.130072867910632 43.82716245096714 10.92254201760641 31.10995 31.10995 25.719 7.623954604075245 32.14613827945354 7.481798681069032 66.0401 66.0401 51.1014 21.126512144222975 68.91145029081565 20.732588125819294 0.0 34.4443 0.0 34.4443 50.1846;34.4443 36.5009;25.719 80.9788;51.1014 1 1 1 360268 SULT1E1_32446 50.1846 50.1846 36.5009 36.5009 80.9788 80.9788 50.1846 36.5009 80.9788 1 294103 PAPSS2_33237 34.4443 34.4443 25.719 25.719 51.1014 51.1014 34.4443 25.719 51.1014 0 Exp 2,2(1) 1.7726719749282283 3.545951247215271 1.7401635646820068 1.8057876825332642 0.04640325874200922 1.7729756236076355 26.888955999999997 57.73994400000001 20.543688000000003 41.676212 36.76024799999999 95.319952 CONFLICT 0.5 0.5 0.0 GO:0045429 6 positive regulation of nitric oxide biosynthetic process 25 28 3 3 3 3 3 3 159 25 2360 0.90193 0.26178 0.41898 10.71 24890;29184;25698 esr1;cd36;ass1 ESR1_33192;CD36_8243;ASS1_33159 32.776833333333336 26.8037 23.3972 13.404538179412723 38.12442424615385 13.536193904577598 25.611533333333337 20.9825 18.3088 10.419331061221412 29.77070912 10.516525965862536 45.921933333333335 36.7081 31.9156 20.251521401695552 53.96645415384615 20.520401953315464 0.5 25.100450000000002 1.5 37.46665 23.3972;48.1296;26.8037 18.3088;37.5433;20.9825 31.9156;69.1421;36.7081 1 2 1 29184 CD36_8243 48.1296 48.1296 37.5433 37.5433 69.1421 69.1421 48.1296 37.5433 69.1421 2 24890;25698 ESR1_33192;ASS1_33159 25.100450000000002 25.100450000000002 2.408759250111924 19.645650000000003 19.645650000000003 1.890591400858429 34.31185 34.31185 3.3888092488365134 23.3972;26.8037 18.3088;20.9825 31.9156;36.7081 0 Exp 2,3(1) 2.30480557918831 6.988726735115051 1.8814297914505005 2.6703107357025146 0.40526049469783537 2.436986207962036 17.60817042989009 47.94549623677658 13.820950291108193 37.40211637555848 23.00517952110727 68.8386871455594 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0048519 4 negative regulation of biological process 1024 1094 100 100 83 89 74 74 88 1020 1365 0.79032 0.2597 0.51187 6.76 257644;79426;24522;308843;246273;29573;293615;79224;24794;24648;25106;252922;83516;29441;85253;25513;81819;25591;24314;81525;25493;24567;24539;299282;288001;24516;81678;54404;50693;306251;192235;65164;63868;24471;24464;25675;113965;81869;29328;29455;299626;25112;294515;25661;246186;361969;83928;80841;24360;308441;24890;29496;116636;24330;116663;140942;25428;65210;25423;113936;25695;114851;29184;246142;79431;25698;155423;25377;25373;50559;25287;170465;312382;25303 zwint;zfp36;zfp354a;tsku;trib3;slc37a4;sirt3;serpind1;serpina3c;serpina1;rgn;pzp;ppargc1a;por;plg;pik3r1;pax8;parp1;nqo1;nfkbib;nfkbia;mt1;lpl;loc299282;kng1;jun;itpr2;itih4;itih3;itih1;hyou1;htra1;hspd1;hspb1;hp;hmgcr;hadh;gstm7;gpx4;gdf15;gadd45b;gadd45a;foxo3;fn1;fgl1;fga;fetub;fabp7;fabp1;exosc5;esr1;erbb3;eif4ebp1;egr1;dusp6;ddit4;cyp7a1;cyp2j4;ctsc;cpb2;cebpd;cdkn1a;cd36;bmf;bhlhe40;ass1;anxa7;ambp;ahsg;acot1;acadl;acaa2;abcg2;abcc2 ZWINT_10214;ZFP36_10204;ZFP354A_10203;TSKU_10094;TRIB3_10079;SLC37A4_9871;SIRT3_9828;SERPIND1_9812;SERPINA3C_32925;SERPINA1_9807;RGN_9699;PZP_9633;PPARGC1A_33189;POR_9531;PLG_9501;PIK3R1_32562;PAX8_9432;PARP1_9425;NQO1_33055;NFKBIB_9308;NFKBIA_9307;MT1A_9255;LPL_32544;LOC299282_9119;KNG1L1_34113;JUN_8938;ITPR2_8931;ITIH4_32725;ITIH3_32422;ITIH1_33132;HYOU1_8857;HTRA1_8856;HSPD1_8849;HSPB1_8847;HP_8823;HMGCR_8810;HADH_8776;GSTM7_8761;GPX4_32827;GDF15_33113;GADD45B_8679;GADD45A_8678;FOXO3_8662;FN1_8655;FGL1_8640;FGA_8632;FETUB_33027;FABP7_8592;FABP1_33091;EXOSC5_32543;ESR1_33192;ERBB3_8571;EIF4EBP1_8550;EGR1_8533;DUSP6_8506;DDIT4_8450;CYP7A1_8430;CYP2J4_32580;CTSC_32456;CPB2_8369;CEBPD_8283;CDKN1A_8271;CD36_8243;BMF_8152;BHLHE40_8141;ASS1_33159;ANXA7_8051;AMBP_33085;AHSG_8003;ACOT1_7968;ACADL_32776;ACAA2_7955;ABCG2_32656;ABCC2_32541 40.768675472972966 33.2224 0.306936 30.506491883720223 43.856004285602 30.30815073907766 27.902845205405406 25.17435 0.0732342 20.769058572300278 30.224893289477617 21.34818532617758 64.67623162162162 46.95565 1.15962 48.77461148965104 67.80301571697481 44.63228286854476 53.5 57.0047 52.0003;0.348134;0.834827;1.38416;108.064;39.7166;2.38018;28.261;29.766;15.797;77.4407;34.1871;42.4094;12.4414;70.7857;18.7324;56.8931;26.9741;87.2765;30.5572;0.520151;12.9315;74.2041;45.2017;24.3655;16.4324;31.8111;57.1163;27.1247;98.1741;40.1982;33.1323;42.2579;89.1011;64.9285;1.63089;33.3125;42.3152;45.9204;105.149;106.367;102.919;13.1992;59.5777;15.4757;28.5803;32.5155;24.601;33.8478;41.9329;23.3972;60.9984;83.9001;0.750017;62.3934;87.5421;5.72128;17.8395;56.2386;25.8316;0.306936;6.24967;48.1296;94.8767;57.8085;26.8037;104.64;17.2343;12.402;31.2018;33.4878;26.5872;5.21654;46.2316 38.9015;0.118102;0.27095;0.540568;83.8836;22.6911;0.56209;22.307;23.347;13.013;58.7732;26.3085;26.2988;8.48981;46.2356;11.6701;45.1162;21.799;60.6992;24.2439;0.160202;8.91033;49.8682;30.7472;19.538;10.5224;24.7342;39.6402;21.5108;42.9071;29.3844;25.6145;23.9469;60.3265;41.6103;0.663137;25.7336;31.4035;34.2198;85.3487;52.7132;89.5012;5.6804;31.0499;10.2138;22.529;19.6094;14.4402;26.4736;31.7336;18.3088;41.6036;42.4185;0.186019;39.0875;53.2453;0.985273;14.6501;38.2681;20.4374;0.0732342;2.44025;37.5433;73.1342;38.3491;20.9825;43.9254;14.1233;10.3013;26.858;26.6039;21.3695;2.73368;31.1788 80.8613;1.15962;2.99857;4.10872;143.428;60.0334;8.82917;38.3264;40.8256;19.9134;89.8047;48.5666;81.7305;79.2355;150.579;41.5978;81.5688;35.2797;197.117;41.2611;2.88499;23.4636;155.425;78.6415;32.1467;39.929;44.3296;101.869;36.4819;104.278;62.3571;46.6629;102.383;106.138;136.455;7.6286;46.9856;64.5991;70.4292;125.652;109.434;115.437;32.7581;105.243;30.4106;38.8511;49.9875;35.6155;46.9257;62.1373;31.9156;113.972;107.32;4.70178;133.304;245.492;22.3625;22.6149;102.888;34.8042;1.73689;19.0606;69.1421;109.848;110.58;36.7081;108.689;21.9073;15.4235;37.2719;45.3228;35.0407;11.386;81.7848 26 48 26 257644;293615;25106;81819;25591;24314;81525;24539;63868;113965;81869;29328;299626;80841;24360;308441;29496;116636;65210;29184;246142;155423;50559;25287;170465;312382 ZWINT_10214;SIRT3_9828;RGN_9699;PAX8_9432;PARP1_9425;NQO1_33055;NFKBIB_9308;LPL_32544;HSPD1_8849;HADH_8776;GSTM7_8761;GPX4_32827;GADD45B_8679;FABP7_8592;FABP1_33091;EXOSC5_32543;ERBB3_8571;EIF4EBP1_8550;CYP2J4_32580;CD36_8243;BMF_8152;ANXA7_8051;ACOT1_7968;ACADL_32776;ACAA2_7955;ABCG2_32656 49.429173846153844 42.28655 28.980595969205474 33.517995 31.568550000000002 17.252564885998655 72.66398346153846 66.8706 44.552520177265734 52.0003;2.38018;77.4407;56.8931;26.9741;87.2765;30.5572;74.2041;42.2579;33.3125;42.3152;45.9204;106.367;24.601;33.8478;41.9329;60.9984;83.9001;17.8395;48.1296;94.8767;104.64;31.2018;33.4878;26.5872;5.21654 38.9015;0.56209;58.7732;45.1162;21.799;60.6992;24.2439;49.8682;23.9469;25.7336;31.4035;34.2198;52.7132;14.4402;26.4736;31.7336;41.6036;42.4185;14.6501;37.5433;73.1342;43.9254;26.858;26.6039;21.3695;2.73368 80.8613;8.82917;89.8047;81.5688;35.2797;197.117;41.2611;155.425;102.383;46.9856;64.5991;70.4292;109.434;35.6155;46.9257;62.1373;113.972;107.32;22.6149;69.1421;109.848;108.689;37.2719;45.3228;35.0407;11.386 48 79426;24522;308843;246273;29573;79224;24794;24648;252922;83516;29441;85253;25513;25493;24567;299282;288001;24516;81678;54404;50693;306251;192235;65164;24471;24464;25675;29455;25112;294515;25661;246186;361969;83928;24890;24330;116663;140942;25428;25423;113936;25695;114851;79431;25698;25377;25373;25303 ZFP36_10204;ZFP354A_10203;TSKU_10094;TRIB3_10079;SLC37A4_9871;SERPIND1_9812;SERPINA3C_32925;SERPINA1_9807;PZP_9633;PPARGC1A_33189;POR_9531;PLG_9501;PIK3R1_32562;NFKBIA_9307;MT1A_9255;LOC299282_9119;KNG1L1_34113;JUN_8938;ITPR2_8931;ITIH4_32725;ITIH3_32422;ITIH1_33132;HYOU1_8857;HTRA1_8856;HSPB1_8847;HP_8823;HMGCR_8810;GDF15_33113;GADD45A_8678;FOXO3_8662;FN1_8655;FGL1_8640;FGA_8632;FETUB_33027;ESR1_33192;EGR1_8533;DUSP6_8506;DDIT4_8450;CYP7A1_8430;CTSC_32456;CPB2_8369;CEBPD_8283;CDKN1A_8271;BHLHE40_8141;ASS1_33159;AMBP_33085;AHSG_8003;ABCC2_32541 36.0775721875 28.420650000000002 30.5738966088731 24.861305733333335 21.9089 22.017269962838714 60.34953270833333 41.2117 50.84051375954211 0.348134;0.834827;1.38416;108.064;39.7166;28.261;29.766;15.797;34.1871;42.4094;12.4414;70.7857;18.7324;0.520151;12.9315;45.2017;24.3655;16.4324;31.8111;57.1163;27.1247;98.1741;40.1982;33.1323;89.1011;64.9285;1.63089;105.149;102.919;13.1992;59.5777;15.4757;28.5803;32.5155;23.3972;0.750017;62.3934;87.5421;5.72128;56.2386;25.8316;0.306936;6.24967;57.8085;26.8037;17.2343;12.402;46.2316 0.118102;0.27095;0.540568;83.8836;22.6911;22.307;23.347;13.013;26.3085;26.2988;8.48981;46.2356;11.6701;0.160202;8.91033;30.7472;19.538;10.5224;24.7342;39.6402;21.5108;42.9071;29.3844;25.6145;60.3265;41.6103;0.663137;85.3487;89.5012;5.6804;31.0499;10.2138;22.529;19.6094;18.3088;0.186019;39.0875;53.2453;0.985273;38.2681;20.4374;0.0732342;2.44025;38.3491;20.9825;14.1233;10.3013;31.1788 1.15962;2.99857;4.10872;143.428;60.0334;38.3264;40.8256;19.9134;48.5666;81.7305;79.2355;150.579;41.5978;2.88499;23.4636;78.6415;32.1467;39.929;44.3296;101.869;36.4819;104.278;62.3571;46.6629;106.138;136.455;7.6286;125.652;115.437;32.7581;105.243;30.4106;38.8511;49.9875;31.9156;4.70178;133.304;245.492;22.3625;102.888;34.8042;1.73689;19.0606;110.58;36.7081;21.9073;15.4235;81.7848 0 Exp 2,27(0.37);Exp 3,4(0.06);Exp 4,5(0.07);Hill,8(0.11);Linear,15(0.21);Poly 2,13(0.18);Power,2(0.03) 2.018654496436147 487.33725452423096 1.5074360370635986 344.14306640625 39.78359043951378 1.7022647261619568 33.81791248320664 47.71943846273929 23.170711330199907 32.63497908061089 53.56316212563619 75.78930111760704 DOWN 0.35135135135135137 0.6486486486486487 0.0 GO:0001678 6 cellular glucose homeostasis 56 60 8 8 7 7 6 6 156 54 2331 0.91685 0.17869 0.2744 10.0 83516;25513;294515;25661;25428;113936 ppargc1a;pik3r1;foxo3;fn1;cyp7a1;cpb2 PPARGC1A_33189;PIK3R1_32562;FOXO3_8662;FN1_8655;CYP7A1_8430;CPB2_8369 27.578596666666666 22.282 5.72128 20.048500566537808 41.646320918196984 20.550744239580336 16.020312166666667 16.05375 0.985273 11.856955931096659 23.185991024470606 10.702025329962083 53.082683333333335 38.201 22.3625 32.75429707500477 77.15380733678937 33.22400544936967 2.0 18.7324 5.0 59.5777 42.4094;18.7324;13.1992;59.5777;5.72128;25.8316 26.2988;11.6701;5.6804;31.0499;0.985273;20.4374 81.7305;41.5978;32.7581;105.243;22.3625;34.8042 0 6 0 6 83516;25513;294515;25661;25428;113936 PPARGC1A_33189;PIK3R1_32562;FOXO3_8662;FN1_8655;CYP7A1_8430;CPB2_8369 27.578596666666666 22.282 20.048500566537808 16.020312166666667 16.05375 11.856955931096659 53.082683333333335 38.201 32.75429707500477 42.4094;18.7324;13.1992;59.5777;5.72128;25.8316 26.2988;11.6701;5.6804;31.0499;0.985273;20.4374 81.7305;41.5978;32.7581;105.243;22.3625;34.8042 0 Exp 2,2(0.34);Exp 4,1(0.17);Hill,1(0.17);Poly 2,1(0.17);Power,1(0.17) 2.049804822652018 13.322192549705505 1.5630855560302734 4.560328960418701 1.1549011550232275 1.7684283256530762 11.536455144667084 43.62073818866625 6.532771468274547 25.507852865058787 26.873787192349564 79.2915794743171 DOWN 0.0 1.0 0.0 GO:0006304 6 DNA modification 15 16 2 2 2 2 2 2 160 14 2371 0.92323 0.27077 0.27077 12.5 25591;308441 parp1;exosc5 PARP1_9425;EXOSC5_32543 34.4535 34.4535 26.9741 10.57746891841332 28.95495332734822 7.170412658790292 26.7663 26.7663 21.799 7.024823028375864 23.11454572999663 4.762091985989389 48.7085 48.7085 35.2797 18.99119108639581 38.83619960722702 12.874032343819467 0.0 26.9741 0.5 34.4535 26.9741;41.9329 21.799;31.7336 35.2797;62.1373 2 0 2 25591;308441 PARP1_9425;EXOSC5_32543 34.4535 34.4535 10.57746891841332 26.7663 26.7663 7.024823028375864 48.7085 48.7085 18.99119108639581 26.9741;41.9329 21.799;31.7336 35.2797;62.1373 0 0 Exp 2,2(1) 1.700061080261474 3.4066439867019653 1.5979743003845215 1.8086696863174438 0.1489841361578861 1.7033219933509827 19.793876000000004 49.11312399999999 17.030392000000003 36.502207999999996 22.388052 75.028948 UP 1.0 0.0 0.0 GO:0035295 4 tube development 61 65 8 8 4 7 4 4 158 61 2324 0.60164 0.60206 1.0 6.15 81819;497840;29184;25698 pax8;cps1;cd36;ass1 PAX8_9432;CPS1_32421;CD36_8243;ASS1_33159 40.95225 40.0561 26.8037 13.979283958415047 43.20931748497522 13.673765312779318 32.0314 31.01345 20.9825 11.264109799121591 33.840184472639095 11.033659657267965 58.252025 57.3656 36.7081 20.71035251484548 61.59927102590236 20.234671042570437 2.5 52.51135 56.8931;31.9826;48.1296;26.8037 45.1162;24.4836;37.5433;20.9825 81.5688;45.5891;69.1421;36.7081 2 2 2 81819;29184 PAX8_9432;CD36_8243 52.51135 52.51135 6.196730276928374 41.329750000000004 41.329750000000004 5.354848943247529 75.35544999999999 75.35544999999999 8.78700383777102 56.8931;48.1296 45.1162;37.5433 81.5688;69.1421 2 497840;25698 CPS1_32421;ASS1_33159 29.39315 29.39315 3.662035309087031 22.73305 22.73305 2.4756515516122723 41.1486 41.1486 6.279815323717738 31.9826;26.8037 24.4836;20.9825 45.5891;36.7081 0 Exp 2,4(1) 2.002450140570248 8.130414009094238 1.7521979808807373 2.6703107357025146 0.42842347263865893 1.8539526462554932 27.252551720753264 54.65194827924674 20.99257239686086 43.070227603139145 37.95587953545143 78.54817046454858 CONFLICT 0.5 0.5 0.0 GO:0006575 4 cellular modified amino acid metabolic process 61 71 14 14 10 14 10 10 152 61 2324 0.99555 0.012898 0.012898 14.08 24856;293656;29441;81869;57298;29328;83842;25698;24158;25287 ttr;rgd1307603;por;gstm7;gstm3l;gpx4;crot;ass1;acadm;acadl TTR_10102;RGD1307603_9684;POR_9531;GSTM7_8761;GSTM3_8760;GPX4_32827;CROT_8384;ASS1_33159;ACADM_7957;ACADL_32776 33.457899999999995 34.1125 7.4229 20.047102198738532 34.1635109015077 19.769726650971624 24.200419 26.39025 5.75707 14.025441831921377 24.254846013087562 13.686192055851654 58.10509999999999 57.31155 10.316 36.527080838285826 61.583883079651955 34.30876722422812 2.5 19.62255 6.5 44.1178 46.6406;34.7372;12.4414;42.3152;73.0961;45.9204;7.4229;26.8037;11.7137;33.4878 28.5876;26.1766;8.48981;31.4035;51.4219;34.2198;5.75707;20.9825;8.36151;26.6039 63.7146;50.9085;79.2355;64.5991;140.853;70.4292;10.316;36.7081;18.9642;45.3228 7 3 7 24856;81869;57298;29328;83842;24158;25287 TTR_10102;GSTM7_8761;GSTM3_8760;GPX4_32827;CROT_8384;ACADM_7957;ACADL_32776 37.228100000000005 42.3152 22.471714236791087 26.622182857142857 28.5876 15.64331090690705 59.17127142857142 63.7146 42.90294316977623 46.6406;42.3152;73.0961;45.9204;7.4229;11.7137;33.4878 28.5876;31.4035;51.4219;34.2198;5.75707;8.36151;26.6039 63.7146;64.5991;140.853;70.4292;10.316;18.9642;45.3228 3 293656;29441;25698 RGD1307603_9684;POR_9531;ASS1_33159 24.66076666666667 26.8037 11.301318368373362 18.549636666666668 20.9825 9.090915967328781 55.61736666666667 50.9085 21.651212590830394 34.7372;12.4414;26.8037 26.1766;8.48981;20.9825 50.9085;79.2355;36.7081 0 Exp 2,5(0.5);Linear,1(0.1);Poly 2,4(0.4) 2.1070709245483603 22.978267192840576 1.547789216041565 5.963563919067383 1.3088898101416844 1.8977435231208801 21.032577326900093 45.88322267309991 15.507360089701098 32.8934779102989 35.46538074168917 80.74481925831083 UP 0.7 0.3 0.0 GO:0045638 7 negative regulation of myeloid cell differentiation 29 31 6 6 5 3 3 3 159 28 2357 0.86955 0.31516 0.44393 9.68 79426;25513;25493 zfp36;pik3r1;nfkbia ZFP36_10204;PIK3R1_32562;NFKBIA_9307 6.5335616666666665 0.520151 0.348134 10.564853996822402 9.112296849423105 11.206254033558338 3.982801333333333 0.160202 0.118102 6.657429210693969 5.6127091120198624 7.055998067596303 15.214136666666667 2.88499 1.15962 22.865202679491677 20.691910074485175 24.363394618949354 0.5 0.4341425 0.348134;18.7324;0.520151 0.118102;11.6701;0.160202 1.15962;41.5978;2.88499 0 3 0 3 79426;25513;25493 ZFP36_10204;PIK3R1_32562;NFKBIA_9307 6.5335616666666665 0.520151 10.564853996822402 3.982801333333333 0.160202 6.657429210693969 15.214136666666667 2.88499 22.865202679491677 0.348134;18.7324;0.520151 0.118102;11.6701;0.160202 1.15962;41.5978;2.88499 0 Exp 4,1(0.34);Hill,1(0.34);Poly 2,1(0.34) 1.8187116031602577 5.466362714767456 1.6735800504684448 1.9381765127182007 0.13525638763700143 1.8546061515808105 -5.421696079401771 18.488819412735104 -3.550789018600547 11.516391685267214 -10.660275940609885 41.08854927394322 DOWN 0.0 1.0 0.0 GO:0051962 6 positive regulation of nervous system development 142 153 5 5 5 4 4 4 158 149 2236 0.027249 0.99092 0.057732 2.61 24825;25513;24471;25661 tf;pik3r1;hspb1;fn1 TF_10003;PIK3R1_32562;HSPB1_8847;FN1_8655 53.141275 52.3658 18.7324 29.338856027274936 58.492036952029515 25.173898957949977 32.794625 29.59095 11.6701 20.240502585225 35.446957265682656 18.14014437128759 78.628225 83.38855 41.5978 32.293422725830204 86.55205734686348 28.984246330387325 45.1539;18.7324;89.1011;59.5777 28.132;11.6701;60.3265;31.0499 61.5341;41.5978;106.138;105.243 1 3 1 24825 TF_10003 45.1539 45.1539 28.132 28.132 61.5341 61.5341 45.1539 28.132 61.5341 3 25513;24471;25661 PIK3R1_32562;HSPB1_8847;FN1_8655 55.803733333333334 59.5777 35.33582605831275 34.34883333333334 31.0499 24.495377851613824 84.32626666666667 105.243 37.00664337674159 18.7324;89.1011;59.5777 11.6701;60.3265;31.0499 41.5978;106.138;105.243 0 Poly 2,3(0.75);Power,1(0.25) 1.7449716221857439 6.984602451324463 1.6735800504684448 1.8344712257385254 0.0742656553210221 1.7382755875587463 24.389196093270566 81.89335390672943 12.958932466479496 52.6303175335205 46.980670728686405 110.2757792713136 DOWN 0.25 0.75 0.0 GO:0006066 4 alcohol metabolic process 93 100 23 23 14 18 10 10 152 90 2295 0.95034 0.099563 0.13962 10.0 24856;293688;360268;29540;25675;246186;25315;298541;25428;65183 ttr;tm7sf2;sult1e1;hsd17b7;hmgcr;fgl1;ephx1;dhdds;cyp7a1;aldh3a2 TTR_10102;TM7SF2_10031;SULT1E1_32446;HSD17B7_8834;HMGCR_8810;FGL1_8640;EPHX1_8567;DHDDS_8467;CYP7A1_8430;ALDH3A2_8024 30.646666400000004 29.291800000000002 0.977494 27.212961614033297 32.53534837280228 24.22214999707417 20.389354200000003 19.4007 0.322682 18.61594275703951 21.629352296854783 16.338500530406733 58.179581999999996 47.062599999999996 5.49472 59.96951496791346 59.05184672605036 54.436109840649586 4.0 15.4757 9.0 82.3097 46.6406;82.3097;50.1846;0.977494;1.63089;15.4757;12.4747;47.9438;5.72128;43.1079 28.5876;51.1696;36.5009;0.322682;0.663137;10.2138;7.00435;36.5688;0.985273;31.8774 63.7146;209.842;80.9788;5.49472;7.6286;30.4106;23.684;71.3742;22.3625;66.3058 5 5 5 24856;360268;25315;298541;65183 TTR_10102;SULT1E1_32446;EPHX1_8567;DHDDS_8467;ALDH3A2_8024 40.07032 46.6406 15.638126981419477 28.10781 31.8774 12.266094964494604 61.21148000000001 66.3058 21.991801193444783 46.6406;50.1846;12.4747;47.9438;43.1079 28.5876;36.5009;7.00435;36.5688;31.8774 63.7146;80.9788;23.684;71.3742;66.3058 5 293688;29540;25675;246186;25428 TM7SF2_10031;HSD17B7_8834;HMGCR_8810;FGL1_8640;CYP7A1_8430 21.2230128 5.72128 34.636147969230485 12.670898400000002 0.985273 21.916922574364822 55.147684000000005 22.3625 87.09277122073496 82.3097;0.977494;1.63089;15.4757;5.72128 51.1696;0.322682;0.663137;10.2138;0.985273 209.842;5.49472;7.6286;30.4106;22.3625 0 Exp 2,2(0.2);Exp 4,2(0.2);Hill,2(0.2);Linear,2(0.2);Poly 2,2(0.2) 1.9607168969440942 20.783417582511902 1.511321783065796 4.560328960418701 0.9110145313850151 1.7457030415534973 13.779898046500879 47.51343475349911 8.85107333890236 31.92763506109764 21.01009153506348 95.34907246493653 CONFLICT 0.5 0.5 0.0 GO:0022407 6 regulation of cell-cell adhesion 137 143 8 8 5 8 5 5 157 138 2247 0.095757 0.95765 0.21342 3.5 25513;63868;246186;361969;25698 pik3r1;hspd1;fgl1;fga;ass1 PIK3R1_32562;HSPD1_8849;FGL1_8640;FGA_8632;ASS1_33159 26.369999999999997 26.8037 15.4757 10.42254280921888 25.98208543302473 10.405024740882885 17.86846 20.9825 10.2138 6.4299843983481075 17.903960140044536 6.595706115736278 49.990120000000005 38.8511 30.4106 29.577408333675876 47.692275035157614 28.894585115421883 18.7324;42.2579;15.4757;28.5803;26.8037 11.6701;23.9469;10.2138;22.529;20.9825 41.5978;102.383;30.4106;38.8511;36.7081 1 4 1 63868 HSPD1_8849 42.2579 42.2579 23.9469 23.9469 102.383 102.383 42.2579 23.9469 102.383 4 25513;246186;361969;25698 PIK3R1_32562;FGL1_8640;FGA_8632;ASS1_33159 22.398025 22.76805 6.297774380088571 16.34885 16.3263 6.30329295976847 36.8919 37.7796 4.761827085618869 18.7324;15.4757;28.5803;26.8037 11.6701;10.2138;22.529;20.9825 41.5978;30.4106;38.8511;36.7081 0 Exp 2,1(0.2);Exp 3,1(0.2);Linear,1(0.2);Poly 2,2(0.4) 1.7523353154192818 8.86007809638977 1.511321783065796 2.2518506050109863 0.3052945351291267 1.6735800504684448 17.234238425832515 35.50576157416749 12.232330174083978 23.50458982591602 24.064378512111727 75.91586148788828 DOWN 0.2 0.8 0.0 GO:0015937 7 coenzyme A biosynthetic process 3 3 2 2 1 2 1 1 161 2 2383 0.98844 0.179 0.179 33.33 298490 ppcs PPCS_9540 20.3353 20.3353 20.3353 20.3353 16.7643 16.7643 16.7643 16.7643 25.6711 25.6711 25.6711 25.671099999999996 0.0 20.3353 0.0 20.3353 20.3353 16.7643 25.6711 1 0 1 298490 PPCS_9540 20.3353 20.3353 16.7643 16.7643 25.6711 25.6711 20.3353 16.7643 25.6711 0 0 Exp 2,1(1) 2.371572256088257 2.371572256088257 2.371572256088257 2.371572256088257 0.0 2.371572256088257 20.3353 20.3353 16.7643 16.7643 25.6711 25.6711 UP 1.0 0.0 0.0 GO:2001169 6 regulation of ATP biosynthetic process 6 6 3 3 3 2 2 2 160 4 2381 0.99562 0.050905 0.050905 33.33 83516;25591 ppargc1a;parp1 PPARGC1A_33189;PARP1_9425 34.69175 34.69175 26.9741 10.914405299648704 33.40401894951325 10.76140049102459 24.0489 24.0489 21.799 3.181839093983229 23.67349218926874 3.1372341275849482 58.5051 58.5051 35.2797 32.84567567154012 54.62981817976003 32.38522490191219 0.0 26.9741 0.0 26.9741 42.4094;26.9741 26.2988;21.799 81.7305;35.2797 1 1 1 25591 PARP1_9425 26.9741 26.9741 21.799 21.799 35.2797 35.2797 26.9741 21.799 35.2797 1 83516 PPARGC1A_33189 42.4094 42.4094 26.2988 26.2988 81.7305 81.7305 42.4094 26.2988 81.7305 0 Exp 2,2(1) 1.7829637063964743 3.5662927627563477 1.7576230764389038 1.8086696863174438 0.03609540400169987 1.7831463813781738 19.565156 49.818343999999996 19.639096 28.458704 12.983315999999995 104.026884 CONFLICT 0.5 0.5 0.0 GO:0043436 5 oxoacid metabolic process 298 332 85 85 60 77 53 53 109 279 2106 1.0 1.303E-11 1.303E-11 15.96 286954;360268;29573;65192;29500;246074;25106;501907;83516;29441;24651;294103;100359982;24552;24539;54404;50693;306251;364070;24443;171155;113965;85255;81869;29328;24957;295143;65030;25315;171142;291075;29740;25428;65210;24894;25146;83842;497840;81718;29184;25698;25284;65183;50681;192272;170570;50559;24158;25287;170465;312382;25303;296925 ugt2b1;sult1e1;slc37a4;slc27a2;slc10a2;scd;rgn;rgd1559459;ppargc1a;por;pklr;papss2;mpc2;me1;lpl;itih4;itih3;itih1;iars2;hdc;hadhb;hadh;hacl1;gstm7;gpx4;glul;etfdh;ephx2;ephx1;ehhadh;eci2;eci1;cyp7a1;cyp2j4;cyp2a1;cyp17a1;crot;cps1;cdo1;cd36;ass1;amacr;aldh3a2;acox1;acot2;acot12;acot1;acadm;acadl;acaa2;abcg2;abcc2;aass UGT2B10_33303,UGT2B1_33224;SULT1E1_32446;SLC37A4_9871;SLC27A2_9860;SLC10A2_9833;SCD1_9787;RGN_9699;RGD1559459_9690;PPARGC1A_33189;POR_9531;PKLR_9489;PAPSS2_33237;MPC2_33219;ME1_9215;LPL_32544;ITIH4_32725;ITIH3_32422;ITIH1_33132;IARS2_8858;HDC_8788;HADHB_8777;HADH_8776;HACL1_8775;GSTM7_8761;GPX4_32827;GLUL_32832;ETFDH_8575;EPHX2_33282;EPHX1_8567;EHHADH_8534;ECI2_8521;ECI1_8520;CYP7A1_8430;CYP2J4_32580;CYP2A1_32717;CYP17A1_32365;CROT_8384;CPS1_32421;CDO1_8275;CD36_8243;ASS1_33159;AMACR_8038;ALDH3A2_8024;ACOX1_7973;ACOT2_7969;ACOT12_32718;ACOT1_7968;ACADM_7957;ACADL_32776;ACAA2_7955;ABCG2_32656;ABCC2_32541;AASS_7936 33.65118754716982 30.3423 2.52378E-13 23.448657274371463 34.99447758404315 23.36375719966261 23.889833452830192 22.6911 2.52378E-13 15.117525132118121 24.566270701192273 14.432945995924 56.77523698113209 41.1025 2.52379E-13 60.8102224215181 58.288262078710844 56.431516408527216 15.5 20.54345 32.5 36.5868 47.47345;50.1846;39.7166;7.62189;56.585;105.46;77.4407;2.52378E-13;42.4094;12.4414;23.0963;34.4443;46.8463;80.7944;74.2041;57.1163;27.1247;98.1741;24.7304;24.5745;31.8029;33.3125;17.6275;42.3152;45.9204;26.4669;18.1231;38.7293;12.4747;8.62809;10.6467;11.9473;5.72128;17.8395;55.3937;49.6922;7.4229;31.9826;22.9638;48.1296;26.8037;2.03774;43.1079;23.1906;8.54905;30.3423;31.2018;11.7137;33.4878;26.5872;5.21654;46.2316;27.4644 34.82915;36.5009;22.6911;5.49916;35.2796;63.7532;58.7732;2.52378E-13;26.2988;8.48981;17.4625;25.719;35.8494;59.856;49.8682;39.6402;21.5108;42.9071;19.8021;21.0619;25.5756;25.7336;11.195;31.4035;34.2198;21.0456;14.869;29.2097;7.00435;7.31865;8.92359;7.15307;0.985273;14.6501;38.7444;35.6654;5.75707;24.4836;18.5144;37.5433;20.9825;1.165;31.8774;16.2815;7.19676;24.0157;26.858;8.36151;26.6039;21.3695;2.73368;31.1788;21.7498 76.47475;80.9788;60.0334;13.3925;116.8;422.699;89.8047;2.52379E-13;81.7305;79.2355;32.9443;51.1014;69.127;94.0621;155.425;101.869;36.4819;104.278;32.7087;29.28;42.1484;46.9856;37.6534;64.5991;70.4292;35.4303;23.0103;57.2113;23.684;10.3909;13.0581;19.001;22.3625;22.6149;96.8569;81.6409;10.316;45.5891;30.0179;69.1421;36.7081;3.73641;66.3058;33.4539;10.4125;41.1025;37.2719;18.9642;45.3228;35.0407;11.386;81.7848;37.0295 37 17 36 286954;360268;65192;246074;25106;100359982;24539;364070;24443;171155;113965;85255;81869;29328;295143;65030;25315;171142;291075;29740;65210;24894;25146;83842;29184;25284;65183;50681;192272;170570;50559;24158;25287;170465;312382;296925 UGT2B10_33303,UGT2B1_33224;SULT1E1_32446;SLC27A2_9860;SCD1_9787;RGN_9699;MPC2_33219;LPL_32544;IARS2_8858;HDC_8788;HADHB_8777;HADH_8776;HACL1_8775;GSTM7_8761;GPX4_32827;ETFDH_8575;EPHX2_33282;EPHX1_8567;EHHADH_8534;ECI2_8521;ECI1_8520;CYP2J4_32580;CYP2A1_32717;CYP17A1_32365;CROT_8384;CD36_8243;AMACR_8038;ALDH3A2_8024;ACOX1_7973;ACOT2_7969;ACOT12_32718;ACOT1_7968;ACADM_7957;ACADL_32776;ACAA2_7955;ABCG2_32656;AASS_7936 31.98446 28.903350000000003 22.693707381202017 23.586558055555557 22.88275 15.453843425531732 55.51829888888889 37.46265 70.52203554134077 47.47345;50.1846;7.62189;105.46;77.4407;46.8463;74.2041;24.7304;24.5745;31.8029;33.3125;17.6275;42.3152;45.9204;18.1231;38.7293;12.4747;8.62809;10.6467;11.9473;17.8395;55.3937;49.6922;7.4229;48.1296;2.03774;43.1079;23.1906;8.54905;30.3423;31.2018;11.7137;33.4878;26.5872;5.21654;27.4644 34.82915;36.5009;5.49916;63.7532;58.7732;35.8494;49.8682;19.8021;21.0619;25.5756;25.7336;11.195;31.4035;34.2198;14.869;29.2097;7.00435;7.31865;8.92359;7.15307;14.6501;38.7444;35.6654;5.75707;37.5433;1.165;31.8774;16.2815;7.19676;24.0157;26.858;8.36151;26.6039;21.3695;2.73368;21.7498 76.47475;80.9788;13.3925;422.699;89.8047;69.127;155.425;32.7087;29.28;42.1484;46.9856;37.6534;64.5991;70.4292;23.0103;57.2113;23.684;10.3909;13.0581;19.001;22.6149;96.8569;81.6409;10.316;69.1421;3.73641;66.3058;33.4539;10.4125;41.1025;37.2719;18.9642;45.3228;35.0407;11.386;37.0295 17 29573;29500;501907;83516;29441;24651;294103;24552;54404;50693;306251;24957;25428;497840;81718;25698;25303 SLC37A4_9871;SLC10A2_9833;RGD1559459_9690;PPARGC1A_33189;POR_9531;PKLR_9489;PAPSS2_33237;ME1_9215;ITIH4_32725;ITIH3_32422;ITIH1_33132;GLUL_32832;CYP7A1_8430;CPS1_32421;CDO1_8275;ASS1_33159;ABCC2_32541 37.180728235294126 31.9826 25.316392363808514 24.53206370588237 22.6911 14.821837366828934 59.43698823529413 51.1014 33.58300505979328 39.7166;56.585;2.52378E-13;42.4094;12.4414;23.0963;34.4443;80.7944;57.1163;27.1247;98.1741;26.4669;5.72128;31.9826;22.9638;26.8037;46.2316 22.6911;35.2796;2.52378E-13;26.2988;8.48981;17.4625;25.719;59.856;39.6402;21.5108;42.9071;21.0456;0.985273;24.4836;18.5144;20.9825;31.1788 60.0334;116.8;2.52379E-13;81.7305;79.2355;32.9443;51.1014;94.0621;101.869;36.4819;104.278;35.4303;22.3625;45.5891;30.0179;36.7081;81.7848 0 Exp 2,22(0.41);Exp 3,1(0.02);Exp 4,2(0.04);Hill,5(0.1);Linear,16(0.3);Poly 2,7(0.13);Power,1(0.02) 2.6632090300190137 527.6372903585434 1.5074360370635986 344.14306640625 46.63166567026256 1.8904055953025818 27.33818280455731 39.96419228978231 19.81979196862399 27.95987493703639 40.40350114762879 73.14697281463535 UP 0.6792452830188679 0.32075471698113206 0.0 GO:0051961 6 negative regulation of nervous system development 77 83 3 3 2 2 2 2 160 81 2304 0.091854 0.97335 0.16947 2.41 294515;25423 foxo3;ctsc FOXO3_8662;CTSC_32456 34.7189 34.7189 13.1992 30.43345159820029 48.23623106939464 23.68033989833669 21.974249999999998 21.974249999999998 5.6804 23.04298365327286 32.20902859101455 17.929799497786373 67.82305 67.82305 32.7581 49.58932785393448 89.8486608626872 38.58557203484166 13.1992;56.2386 5.6804;38.2681 32.7581;102.888 0 2 0 2 294515;25423 FOXO3_8662;CTSC_32456 34.7189 34.7189 30.43345159820029 21.974249999999998 21.974249999999998 23.04298365327286 67.82305 67.82305 49.58932785393448 13.1992;56.2386 5.6804;38.2681 32.7581;102.888 0 Exp 2,1(0.5);Exp 4,1(0.5) 1.7688798153319198 3.56198251247406 1.5736411809921265 1.9883413314819336 0.29323728857042436 1.78099125623703 -7.459711999999996 76.89751199999999 -9.961695999999996 53.91019599999999 -0.9042519999999996 136.55035199999998 DOWN 0.0 1.0 0.0 GO:0009416 5 response to light stimulus 83 88 11 11 9 10 8 8 154 80 2305 0.89676 0.19336 0.26576 9.09 29482;25513;25591;25675;314322;114851;246142;79431 slc1a2;pik3r1;parp1;hmgcr;fos;cdkn1a;bmf;bhlhe40 SLC1A2_33059;PIK3R1_32562;PARP1_9425;HMGCR_8810;FOS_8657;CDKN1A_8271;BMF_8152;BHLHE40_8141 27.44947000000016 16.027949999999997 1.28141E-12 32.979132707589784 35.150469032002256 37.941753332133764 19.64566337500016 10.38981 1.28141E-12 25.163503972684296 26.06665967383067 29.73982736921507 43.58400000000016 29.978499999999997 1.28142E-12 43.26579711263174 49.19185011278856 42.366979825679934 3.5 16.027949999999997 13.3235;18.7324;26.9741;1.63089;1.28141E-12;6.24967;94.8767;57.8085 9.10952;11.6701;21.799;0.663137;1.28141E-12;2.44025;73.1342;38.3491 24.6773;41.5978;35.2797;7.6286;1.28142E-12;19.0606;109.848;110.58 2 6 2 25591;246142 PARP1_9425;BMF_8152 60.925399999999996 60.925399999999996 48.014388920197675 47.4666 47.4666 36.29946803356768 72.56385 72.56385 52.727750591552805 26.9741;94.8767 21.799;73.1342 35.2797;109.848 6 29482;25513;25675;314322;114851;79431 SLC1A2_33059;PIK3R1_32562;HMGCR_8810;FOS_8657;CDKN1A_8271;BHLHE40_8141 16.290826666666877 9.786584999999999 21.538863064984152 10.372017833333546 5.774884999999999 14.496552049254568 33.924050000000214 21.868949999999998 40.20879878841176 13.3235;18.7324;1.63089;1.28141E-12;6.24967;57.8085 9.10952;11.6701;0.663137;1.28141E-12;2.44025;38.3491 24.6773;41.5978;7.6286;1.28142E-12;19.0606;110.58 0 Exp 2,2(0.25);Exp 4,2(0.25);Hill,1(0.13);Poly 2,3(0.38) 1.724024686564539 13.828008651733398 1.522104263305664 1.9017701148986816 0.13277784553924205 1.7024496793746948 4.596096992316113 50.30284300768421 2.2082447634504625 37.08308198654986 13.602332238852583 73.56566776114774 DOWN 0.25 0.75 0.0 GO:0035690 5 cellular response to drug 160 174 22 22 19 18 15 15 147 159 2226 0.91831 0.13579 0.19857 8.62 286954;170698;83516;24314;58954;81678;24471;81869;24360;116636;24330;140942;25698;312382;25303 ugt2b1;slco1a2;ppargc1a;nqo1;klf6;itpr2;hspb1;gstm7;fabp1;eif4ebp1;egr1;ddit4;ass1;abcg2;abcc2 UGT2B10_33303,UGT2B1_33224;SLCO1A2_9886;PPARGC1A_33189;NQO1_33055;KLF6_8969;ITPR2_8931;HSPB1_8847;GSTM7_8761;FABP1_33091;EIF4EBP1_8550;EGR1_8533;DDIT4_8450;ASS1_33159;ABCG2_32656;ABCC2_32541 49.85488046666667 42.4094 0.750017 32.81602911375788 42.261284427989324 29.831478173666593 33.83426326666667 31.1788 0.186019 22.355205828990798 28.33643752910517 19.05639581362173 85.24449533333333 76.47475 4.70178 65.75149587009983 65.79661175495376 48.66897533466913 7.5 44.320499999999996 47.47345;104.197;42.4094;87.2765;18.9476;31.8111;89.1011;42.3152;33.8478;83.9001;0.750017;87.5421;26.8037;5.21654;46.2316 34.82915;80.3101;26.2988;60.6992;11.6941;24.7342;60.3265;31.4035;26.4736;42.4185;0.186019;53.2453;20.9825;2.73368;31.1788 76.47475;128.412;81.7305;197.117;45.5481;44.3296;106.138;64.5991;46.9257;107.32;4.70178;245.492;36.7081;11.386;81.7848 7 9 6 286954;24314;81869;24360;116636;312382 UGT2B10_33303,UGT2B1_33224;NQO1_33055;GSTM7_8761;FABP1_33091;EIF4EBP1_8550;ABCG2_32656 50.004931666666664 44.894324999999995 31.211041465116423 33.09293833333333 33.116325 19.08109338042285 83.97042499999999 70.536925 63.90554571518617 47.47345;87.2765;42.3152;33.8478;83.9001;5.21654 34.82915;60.6992;31.4035;26.4736;42.4185;2.73368 76.47475;197.117;64.5991;46.9257;107.32;11.386 9 170698;83516;58954;81678;24471;24330;140942;25698;25303 SLCO1A2_9886;PPARGC1A_33189;KLF6_8969;ITPR2_8931;HSPB1_8847;EGR1_8533;DDIT4_8450;ASS1_33159;ABCC2_32541 49.75484633333334 42.4094 35.71696731740001 34.32847988888889 26.2988 25.42301353513614 86.09387555555556 81.7305 70.7900085731198 104.197;42.4094;18.9476;31.8111;89.1011;0.750017;87.5421;26.8037;46.2316 80.3101;26.2988;11.6941;24.7342;60.3265;0.186019;53.2453;20.9825;31.1788 128.412;81.7305;45.5481;44.3296;106.138;4.70178;245.492;36.7081;81.7848 0 Exp 2,7(0.44);Exp 3,1(0.07);Exp 4,1(0.07);Hill,1(0.07);Linear,3(0.19);Poly 2,3(0.19) 1.7945267626773 29.70059061050415 1.5074360370635986 4.21828556060791 0.6397742239518304 1.6850852370262146 33.247678391824365 66.46208254150895 22.520968189441874 45.14755834389146 51.96964739689868 118.51934326976799 DOWN 0.4 0.6 0.0 GO:0007263 7 nitric oxide mediated signal transduction 7 9 2 2 2 2 2 2 160 7 2378 0.98404 0.10782 0.10782 22.22 24567;29184 mt1;cd36 MT1A_9255;CD36_8243 30.53055 30.53055 12.9315 24.88881519488222 41.443658915081464 19.52591174363282 23.226815000000002 23.226815000000002 8.91033 20.24656725251098 32.10441692090653 15.883949564836911 46.30285 46.30285 23.4636 32.299577104429716 60.46538847729135 25.33984390014046 0.0 12.9315 0.0 12.9315 12.9315;48.1296 8.91033;37.5433 23.4636;69.1421 1 1 1 29184 CD36_8243 48.1296 48.1296 37.5433 37.5433 69.1421 69.1421 48.1296 37.5433 69.1421 1 24567 MT1A_9255 12.9315 12.9315 8.91033 8.91033 23.4636 23.4636 12.9315 8.91033 23.4636 0 Exp 2,1(0.5);Poly 2,1(0.5) 2.4638671466960487 4.943694591522217 2.273383855819702 2.6703107357025146 0.28066968840035494 2.4718472957611084 -3.963587999999998 65.024688 -4.833495599999996 51.287125599999996 1.5379200000000068 91.06778 CONFLICT 0.5 0.5 0.0 GO:0009746 7 response to hexose 94 98 17 16 13 15 12 12 150 86 2299 0.99201 0.019555 0.030678 12.24 29573;25351;83516;24651;25513;24957;294515;25661;24330;25428;113936;367313 slc37a4;slc2a2;ppargc1a;pklr;pik3r1;glul;foxo3;fn1;egr1;cyp7a1;cpb2;col6a3 SLC37A4_9871;SLC2A2_9863;PPARGC1A_33189;PKLR_9489;PIK3R1_32562;GLUL_32832;FOXO3_8662;FN1_8655;EGR1_8533;CYP7A1_8430;CPB2_8369;COL6A3_33029 29.032408083333333 26.149250000000002 0.750017 19.40375578605222 37.0328034301122 21.538407101906994 18.624832666666666 20.741500000000002 0.186019 12.45669688388497 23.02257631234152 13.113909987427457 51.13023999999999 38.119150000000005 4.70178 34.65197379975399 65.26738589843343 40.32735472732786 3.5 20.91435 8.5 41.063 39.7166;29.7555;42.4094;23.0963;18.7324;26.4669;13.1992;59.5777;0.750017;5.72128;25.8316;63.132 22.6911;23.3399;26.2988;17.4625;11.6701;21.0456;5.6804;31.0499;0.186019;0.985273;20.4374;42.651 60.0334;40.808;81.7305;32.9443;41.5978;35.4303;32.7581;105.243;4.70178;22.3625;34.8042;121.149 0 12 0 12 29573;25351;83516;24651;25513;24957;294515;25661;24330;25428;113936;367313 SLC37A4_9871;SLC2A2_9863;PPARGC1A_33189;PKLR_9489;PIK3R1_32562;GLUL_32832;FOXO3_8662;FN1_8655;EGR1_8533;CYP7A1_8430;CPB2_8369;COL6A3_33029 29.032408083333333 26.149250000000002 19.40375578605222 18.624832666666666 20.741500000000002 12.45669688388497 51.13023999999999 38.119150000000005 34.65197379975399 39.7166;29.7555;42.4094;23.0963;18.7324;26.4669;13.1992;59.5777;0.750017;5.72128;25.8316;63.132 22.6911;23.3399;26.2988;17.4625;11.6701;21.0456;5.6804;31.0499;0.186019;0.985273;20.4374;42.651 60.0334;40.808;81.7305;32.9443;41.5978;35.4303;32.7581;105.243;4.70178;22.3625;34.8042;121.149 0 Exp 2,3(0.25);Exp 4,1(0.09);Hill,2(0.17);Linear,3(0.25);Poly 2,2(0.17);Power,1(0.09) 2.173162234211033 27.92358922958374 1.5630855560302734 4.560328960418701 1.0177560557027328 1.8364092707633972 18.05369972949367 40.011116437173 11.576792913524601 25.67287241980874 31.524040126784975 70.73643987321503 DOWN 0.0 1.0 0.0 GO:0033986 5 response to methanol 1 1 1 1 1 1 1 1 161 0 2385 1.0 0.063604 0.063604 100.0 24648 serpina1 SERPINA1_9807 15.797 15.797 15.797 15.797 13.013 13.013 13.013 13.013 19.9134 19.9134 19.9134 19.9134 0.0 15.797 0.0 15.797 15.797 13.013 19.9134 0 1 0 1 24648 SERPINA1_9807 15.797 15.797 13.013 13.013 19.9134 19.9134 15.797 13.013 19.9134 0 Exp 2,1(1) 1.7033517360687256 1.7033517360687256 1.7033517360687256 1.7033517360687256 0.0 1.7033517360687256 15.797 15.797 13.013 13.013 19.9134 19.9134 DOWN 0.0 1.0 0.0 GO:0046889 7 positive regulation of lipid biosynthetic process 46 50 7 7 6 7 6 6 156 44 2341 0.96359 0.094288 0.13048 12.0 293615;25106;83516;29441;25428;25146 sirt3;rgn;ppargc1a;por;cyp7a1;cyp17a1 SIRT3_9828;RGN_9699;PPARGC1A_33189;POR_9531;CYP7A1_8430;CYP17A1_32365 31.68086 27.4254 2.38018 29.786101991644358 33.679304432826 30.260278096811874 21.795762166666666 17.394305 0.56209 22.982466221767154 23.47048872309361 23.156385625433646 60.60054500000001 80.4382 8.82917 35.30365167728897 65.88437750396963 33.9442027646482 1.5 9.08134 4.0 49.6922 2.38018;77.4407;42.4094;12.4414;5.72128;49.6922 0.56209;58.7732;26.2988;8.48981;0.985273;35.6654 8.82917;89.8047;81.7305;79.2355;22.3625;81.6409 3 3 3 293615;25106;25146 SIRT3_9828;RGN_9699;CYP17A1_32365 43.17102666666667 49.6922 37.952795574241094 31.666896666666663 35.6654 29.31082314671551 60.09159 81.6409 44.58182012662001 2.38018;77.4407;49.6922 0.56209;58.7732;35.6654 8.82917;89.8047;81.6409 3 83516;29441;25428 PPARGC1A_33189;POR_9531;CYP7A1_8430 20.190693333333332 12.4414 19.53313076949349 11.924627666666666 8.48981 13.001620729638532 61.109500000000004 79.2355 33.57906733368275 42.4094;12.4414;5.72128 26.2988;8.48981;0.985273 81.7305;79.2355;22.3625 0 Exp 2,1(0.17);Hill,2(0.34);Linear,1(0.17);Poly 2,2(0.34) 2.072946858141429 13.450144171714783 1.5209722518920898 4.560328960418701 1.1471712813664623 1.833514153957367 7.847014573364689 55.51470542663531 3.4059591771340294 40.18556515619931 32.351740329005544 88.84934967099446 CONFLICT 0.5 0.5 0.0 GO:0002931 4 response to ischemia 27 28 7 7 7 7 7 7 155 21 2364 0.99977 0.0014028 0.0014028 25.0 83516;192235;63868;24471;25661;116636;24330 ppargc1a;hyou1;hspd1;hspb1;fn1;eif4ebp1;egr1 PPARGC1A_33189;HYOU1_8857;HSPD1_8849;HSPB1_8847;FN1_8655;EIF4EBP1_8550;EGR1_8533 51.17063100000001 42.4094 0.750017 29.998460875665923 53.468958523788054 30.213918762261265 30.515859857142857 29.3844 0.186019 18.315506100218656 31.185728126771995 18.654924176437692 81.41048285714285 102.383 4.70178 37.72255610505989 85.05140405129474 37.91332967666361 0.5 20.4741085 1.5 41.228049999999996 42.4094;40.1982;42.2579;89.1011;59.5777;83.9001;0.750017 26.2988;29.3844;23.9469;60.3265;31.0499;42.4185;0.186019 81.7305;62.3571;102.383;106.138;105.243;107.32;4.70178 2 5 2 63868;116636 HSPD1_8849;EIF4EBP1_8550 63.07899999999999 63.07899999999999 29.44548200352646 33.1827 33.1827 13.061393619365457 104.85149999999999 104.85149999999999 3.4909861787185217 42.2579;83.9001 23.9469;42.4185 102.383;107.32 5 83516;192235;24471;25661;24330 PPARGC1A_33189;HYOU1_8857;HSPB1_8847;FN1_8655;EGR1_8533 46.4072834 42.4094 32.15331869636753 29.449123800000002 29.3844 21.34380985900671 72.034076 81.7305 41.79477495142043 42.4094;40.1982;89.1011;59.5777;0.750017 26.2988;29.3844;60.3265;31.0499;0.186019 81.7305;62.3571;106.138;105.243;4.70178 0 Exp 2,2(0.29);Exp 3,2(0.29);Hill,1(0.15);Poly 2,1(0.15);Power,1(0.15) 2.0244099567493077 15.029254913330078 1.6520916223526 4.21828556060791 0.9363090752096569 1.7576230764389038 28.947460186320356 73.39380181367963 16.94754305945266 44.08417665483307 53.46522222107532 109.35574349321038 DOWN 0.2857142857142857 0.7142857142857143 0.0 GO:1902531 6 regulation of intracellular signal transduction 377 399 28 28 23 26 21 21 141 378 2007 0.19466 0.86325 0.37224 5.26 246273;24825;293615;297784;25106;25591;24516;192235;24471;25675;81869;29455;299626;25112;25661;361969;24890;29496;116663;140942;29184 trib3;tf;sirt3;rrs1;rgn;parp1;jun;hyou1;hspb1;hmgcr;gstm7;gdf15;gadd45b;gadd45a;fn1;fga;esr1;erbb3;dusp6;ddit4;cd36 TRIB3_10079;TF_10003;SIRT3_9828;RRS1_9755;RGN_9699;PARP1_9425;JUN_8938;HYOU1_8857;HSPB1_8847;HMGCR_8810;GSTM7_8761;GDF15_33113;GADD45B_8679;GADD45A_8678;FN1_8655;FGA_8632;ESR1_33192;ERBB3_8571;DUSP6_8506;DDIT4_8450;CD36_8243 56.911160476190474 59.5777 1.63089 34.03367190740201 58.803428897961346 31.326320579181306 39.97568223809524 37.5433 0.56209 25.534908617669306 42.521654405967844 25.503308192521175 86.32915571428572 89.8047 7.6286 54.64932363161948 84.97781185392566 43.680243381969625 18.5 105.75800000000001 108.064;45.1539;2.38018;60.39;77.4407;26.9741;16.4324;40.1982;89.1011;1.63089;42.3152;105.149;106.367;102.919;59.5777;28.5803;23.3972;60.9984;62.3934;87.5421;48.1296 83.8836;28.132;0.56209;43.109;58.7732;21.799;10.5224;29.3844;60.3265;0.663137;31.4035;85.3487;52.7132;89.5012;31.0499;22.529;18.3088;41.6036;39.0875;53.2453;37.5433 143.428;61.5341;8.82917;104.942;89.8047;35.2797;39.929;62.3571;106.138;7.6286;64.5991;125.652;109.434;115.437;105.243;38.8511;31.9156;113.972;133.304;245.492;69.1421 9 12 9 24825;293615;297784;25106;25591;81869;299626;29496;29184 TF_10003;SIRT3_9828;RRS1_9755;RGN_9699;PARP1_9425;GSTM7_8761;GADD45B_8679;ERBB3_8571;CD36_8243 52.23878666666667 48.1296 29.57599676353444 35.07098777777779 37.5433 17.374727373281118 73.05965222222223 69.1421 35.472595499220155 45.1539;2.38018;60.39;77.4407;26.9741;42.3152;106.367;60.9984;48.1296 28.132;0.56209;43.109;58.7732;21.799;31.4035;52.7132;41.6036;37.5433 61.5341;8.82917;104.942;89.8047;35.2797;64.5991;109.434;113.972;69.1421 12 246273;24516;192235;24471;25675;29455;25112;25661;361969;24890;116663;140942 TRIB3_10079;JUN_8938;HYOU1_8857;HSPB1_8847;HMGCR_8810;GDF15_33113;GADD45A_8678;FN1_8655;FGA_8632;ESR1_33192;DUSP6_8506;DDIT4_8450 60.41544083333333 60.98555 37.92823406305423 43.654203083333336 35.0687 30.520782062599803 96.28128333333335 105.6905 65.29045285921606 108.064;16.4324;40.1982;89.1011;1.63089;105.149;102.919;59.5777;28.5803;23.3972;62.3934;87.5421 83.8836;10.5224;29.3844;60.3265;0.663137;85.3487;89.5012;31.0499;22.529;18.3088;39.0875;53.2453 143.428;39.929;62.3571;106.138;7.6286;125.652;115.437;105.243;38.8511;31.9156;133.304;245.492 0 Exp 2,6(0.29);Exp 4,1(0.05);Hill,1(0.05);Linear,4(0.2);Poly 2,7(0.34);Power,2(0.1) 1.7931928627619182 38.102877140045166 1.5209722518920898 2.6703107357025146 0.3047042802734533 1.7198865413665771 42.35471855818072 71.46760239420026 29.0542214216986 50.89714305449189 62.95525390708242 109.70305752148901 CONFLICT 0.42857142857142855 0.5714285714285714 0.0 GO:0034030 8 ribonucleoside bisphosphate biosynthetic process 15 17 6 6 4 5 3 3 159 14 2371 0.98046 0.089037 0.089037 17.65 298490;294103;100359982 ppcs;papss2;mpc2 PPCS_9540;PAPSS2_33237;MPC2_33219 33.8753 34.4443 20.3353 13.264656082989859 34.05384215152784 14.058053559109318 26.1109 25.719 16.7643 9.54858364942153 26.33964645458351 10.12786331856666 48.63316666666666 51.1014 25.6711 21.832840929282046 48.73383491837589 23.099761375440636 0.0 20.3353 0.5 27.3898 20.3353;34.4443;46.8463 16.7643;25.719;35.8494 25.6711;51.1014;69.127 2 1 2 298490;100359982 PPCS_9540;MPC2_33219 33.5908 33.5908 18.746107876036557 26.30685 26.30685 13.495203629623386 47.399049999999995 47.399049999999995 30.7279615725645 20.3353;46.8463 16.7643;35.8494 25.6711;69.127 1 294103 PAPSS2_33237 34.4443 34.4443 25.719 25.719 51.1014 51.1014 34.4443 25.719 51.1014 0 Exp 2,3(1) 2.019206488692619 6.0997395515441895 1.8057876825332642 2.371572256088257 0.2987417760594201 1.9223796129226685 18.864928589964876 48.88567141003513 15.305660412868578 36.916139587131426 23.926981354783937 73.33935197854939 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0071345 6 cellular response to cytokine stimulus 172 189 15 15 12 13 11 11 151 178 2207 0.45094 0.67012 0.87719 5.82 79426;83516;25493;89783;63868;24471;25661;361969;24330;25698;25303 zfp36;ppargc1a;nfkbia;laptm5;hspd1;hspb1;fn1;fga;egr1;ass1;abcc2 ZFP36_10204;PPARGC1A_33189;NFKBIA_9307;LAPTM5_32639;HSPD1_8849;HSPB1_8847;FN1_8655;FGA_8632;EGR1_8533;ASS1_33159;ABCC2_32541 34.114000181818184 38.674 0.348134 27.277547292597706 40.18748434916262 26.51024235037572 21.945820272727275 23.9469 0.118102 17.598782143234363 25.59773346529413 16.82068238523791 57.51486272727273 71.0786 1.15962 42.12546939699975 66.30762110638014 40.00272577816798 8.5 52.904650000000004 0.348134;42.4094;0.520151;38.674;42.2579;89.1011;59.5777;28.5803;0.750017;26.8037;46.2316 0.118102;26.2988;0.160202;24.6273;23.9469;60.3265;31.0499;22.529;0.186019;20.9825;31.1788 1.15962;81.7305;2.88499;71.0786;102.383;106.138;105.243;38.8511;4.70178;36.7081;81.7848 1 10 1 63868 HSPD1_8849 42.2579 42.2579 23.9469 23.9469 102.383 102.383 42.2579 23.9469 102.383 10 79426;83516;25493;89783;24471;25661;361969;24330;25698;25303 ZFP36_10204;PPARGC1A_33189;NFKBIA_9307;LAPTM5_32639;HSPB1_8847;FN1_8655;FGA_8632;EGR1_8533;ASS1_33159;ABCC2_32541 33.2996102 33.62715 28.611750593701508 21.7457123 23.57815 18.537549212245626 53.028048999999996 54.96485 41.54126061669676 0.348134;42.4094;0.520151;38.674;89.1011;59.5777;28.5803;0.750017;26.8037;46.2316 0.118102;26.2988;0.160202;24.6273;60.3265;31.0499;22.529;0.186019;20.9825;31.1788 1.15962;81.7305;2.88499;71.0786;106.138;105.243;38.8511;4.70178;36.7081;81.7848 0 Exp 2,4(0.37);Exp 3,1(0.1);Exp 4,1(0.1);Hill,2(0.19);Linear,1(0.1);Poly 2,1(0.1);Power,1(0.1) 1.9614324243086865 22.47079885005951 1.541895866394043 4.21828556060791 0.7434491321431135 1.8546061515808105 17.993999858307827 50.23400050532854 11.545604637529317 32.34603590792523 32.62030116630943 82.40942428823602 DOWN 0.09090909090909091 0.9090909090909091 0.0 GO:0050789 3 regulation of biological process 1644 1779 147 146 116 131 105 105 57 1674 711 0.089113 0.93557 0.15714 5.9 257644;79426;24522;312688;24856;308843;246273;25357;24825;360268;362895;170698;29573;29482;293615;79224;24794;24648;246074;297784;25106;308821;252922;192280;83516;29441;303612;298199;85253;363465;25513;360722;81819;25591;24314;81525;25493;24567;100359982;24552;24539;299282;307582;288001;58954;24516;81678;54404;50693;306251;25685;494344;192235;65164;63868;24471;24464;25675;113965;81869;29328;290556;24957;29455;299626;25112;289388;294515;314322;25661;246186;361969;83928;80841;24360;308441;24890;29496;65030;116636;24330;116663;140942;25428;65210;25146;25423;113936;170945;25695;114851;29184;313421;246142;79431;25698;155423;25377;25373;50559;24158;25287;170465;312382;25303 zwint;zfp36;zfp354a;usp18;ttr;tsku;trib3;thrsp;tf;sult1e1;stac3;slco1a2;slc37a4;slc1a2;sirt3;serpind1;serpina3c;serpina1;scd;rrs1;rgn;rab30;pzp;ppp1r3b;ppargc1a;por;polg2;plin2;plg;pir;pik3r1;pdia5;pax8;parp1;nqo1;nfkbib;nfkbia;mt1;mpc2;me1;lpl;loc299282;lama3;kng1;klf6;jun;itpr2;itih4;itih3;itih1;igfbp1;ier2;hyou1;htra1;hspd1;hspb1;hp;hmgcr;hadh;gstm7;gpx4;gnl3;glul;gdf15;gadd45b;gadd45a;g0s2;foxo3;fos;fn1;fgl1;fga;fetub;fabp7;fabp1;exosc5;esr1;erbb3;ephx2;eif4ebp1;egr1;dusp6;ddit4;cyp7a1;cyp2j4;cyp17a1;ctsc;cpb2;chrna2;cebpd;cdkn1a;cd36;c8b;bmf;bhlhe40;ass1;anxa7;ambp;ahsg;acot1;acadm;acadl;acaa2;abcg2;abcc2 ZWINT_10214;ZFP36_10204;ZFP354A_10203;USP18_10138;TTR_10102;TSKU_10094;TRIB3_10079;THRSP_33314;TF_10003;SULT1E1_32446;STAC3_9953;SLCO1A2_9886;SLC37A4_9871;SLC1A2_33059;SIRT3_9828;SERPIND1_9812;SERPINA3C_32925;SERPINA1_9807;SCD1_9787;RRS1_9755;RGN_9699;RAB30_9639;PZP_9633;PPP1R3B_9545;PPARGC1A_33189;POR_9531;POLG2_9521;PLIN2_9502;PLG_9501;PIR_9487;PIK3R1_32562;PDIA5_9451;PAX8_9432;PARP1_9425;NQO1_33055;NFKBIB_9308;NFKBIA_9307;MT1A_9255;MPC2_33219;ME1_9215;LPL_32544;LOC299282_9119;LAMA3_8980;KNG1L1_34113;KLF6_8969;JUN_8938;ITPR2_8931;ITIH4_32725;ITIH3_32422;ITIH1_33132;IGFBP1_32306;IER2_32643;HYOU1_8857;HTRA1_8856;HSPD1_8849;HSPB1_8847;HP_8823;HMGCR_8810;HADH_8776;GSTM7_8761;GPX4_32827;GNL3_8735;GLUL_32832;GDF15_33113;GADD45B_8679;GADD45A_8678;G0S2_32729;FOXO3_8662;FOS_8657;FN1_8655;FGL1_8640;FGA_8632;FETUB_33027;FABP7_8592;FABP1_33091;EXOSC5_32543;ESR1_33192;ERBB3_8571;EPHX2_33282;EIF4EBP1_8550;EGR1_8533;DUSP6_8506;DDIT4_8450;CYP7A1_8430;CYP2J4_32580;CYP17A1_32365;CTSC_32456;CPB2_8369;CHRNA2_32401;CEBPD_8283;CDKN1A_8271;CD36_8243;C8B_8181;BMF_8152;BHLHE40_8141;ASS1_33159;ANXA7_8051;AMBP_33085;AHSG_8003;ACOT1_7968;ACADM_7957;ACADL_32776;ACAA2_7955;ABCG2_32656;ABCC2_32541 43.18837061904762 38.7293 1.28141E-12 30.4924945068269 44.29421012538593 28.896723522468996 29.719812154285737 26.6039 1.28141E-12 20.583063078295233 30.706897139666314 20.098109707967176 70.62028704761906 60.0334 1.28142E-12 59.522138586909705 70.35386295532177 52.3202959684368 87.5 79.11755 52.0003;0.348134;0.834827;108.883;46.6406;1.38416;108.064;32.2053;45.1539;50.1846;63.2393;104.197;39.7166;13.3235;2.38018;28.261;29.766;15.797;105.46;60.39;77.4407;26.4203;34.1871;36.1411;42.4094;12.4414;63.7758;25.6517;70.7857;50.0307;18.7324;107.066;56.8931;26.9741;87.2765;30.5572;0.520151;12.9315;46.8463;80.7944;74.2041;45.2017;2.46923;24.3655;18.9476;16.4324;31.8111;57.1163;27.1247;98.1741;49.0259;49.6814;40.1982;33.1323;42.2579;89.1011;64.9285;1.63089;33.3125;42.3152;45.9204;87.6357;26.4669;105.149;106.367;102.919;46.3784;13.1992;1.28141E-12;59.5777;15.4757;28.5803;32.5155;24.601;33.8478;41.9329;23.3972;60.9984;38.7293;83.9001;0.750017;62.3934;87.5421;5.72128;17.8395;49.6922;56.2386;25.8316;49.3913;0.306936;6.24967;48.1296;21.3618;94.8767;57.8085;26.8037;104.64;17.2343;12.402;31.2018;11.7137;33.4878;26.5872;5.21654;46.2316 38.9015;0.118102;0.27095;73.1414;28.5876;0.540568;83.8836;24.3966;28.132;36.5009;42.7031;80.3101;22.6911;9.10952;0.56209;22.307;23.347;13.013;63.7532;43.109;58.7732;21.0125;26.3085;27.0588;26.2988;8.48981;40.9553;20.9252;46.2356;38.7717;11.6701;61.3361;45.1162;21.799;60.6992;24.2439;0.160202;8.91033;35.8494;59.856;49.8682;30.7472;0.871501;19.538;11.6941;10.5224;24.7342;39.6402;21.5108;42.9071;32.6883;33.4626;29.3844;25.6145;23.9469;60.3265;41.6103;0.663137;25.7336;31.4035;34.2198;54.41;21.0456;85.3487;52.7132;89.5012;33.7914;5.6804;1.28141E-12;31.0499;10.2138;22.529;19.6094;14.4402;26.4736;31.7336;18.3088;41.6036;29.2097;42.4185;0.186019;39.0875;53.2453;0.985273;14.6501;35.6654;38.2681;20.4374;41.8524;0.0732342;2.44025;37.5433;17.2088;73.1342;38.3491;20.9825;43.9254;14.1233;10.3013;26.858;8.36151;26.6039;21.3695;2.73368;31.1788 80.8613;1.15962;2.99857;138.144;63.7146;4.10872;143.428;46.6068;61.5341;80.9788;121.52;128.412;60.0334;24.6773;8.82917;38.3264;40.8256;19.9134;422.699;104.942;89.8047;35.3561;48.5666;53.6244;81.7305;79.2355;132.567;33.0375;150.579;73.0083;41.5978;114.259;81.5688;35.2797;197.117;41.2611;2.88499;23.4636;69.127;94.0621;155.425;78.6415;10.4175;32.1467;45.5481;39.929;44.3296;101.869;36.4819;104.278;89.1623;89.4404;62.3571;46.6629;102.383;106.138;136.455;7.6286;46.9856;64.5991;70.4292;238.963;35.4303;125.652;109.434;115.437;73.6529;32.7581;1.28142E-12;105.243;30.4106;38.8511;49.9875;35.6155;46.9257;62.1373;31.9156;113.972;57.2113;107.32;4.70178;133.304;245.492;22.3625;22.6149;81.6409;102.888;34.8042;62.472;1.73689;19.0606;69.1421;27.9161;109.848;110.58;36.7081;108.689;21.9073;15.4235;37.2719;18.9642;45.3228;35.0407;11.386;81.7848 42 63 42 257644;312688;24856;24825;360268;293615;246074;297784;25106;308821;298199;363465;81819;25591;24314;81525;100359982;24539;63868;113965;81869;29328;290556;299626;289388;80841;24360;308441;29496;65030;116636;65210;25146;170945;29184;246142;155423;50559;24158;25287;170465;312382 ZWINT_10214;USP18_10138;TTR_10102;TF_10003;SULT1E1_32446;SIRT3_9828;SCD1_9787;RRS1_9755;RGN_9699;RAB30_9639;PLIN2_9502;PIR_9487;PAX8_9432;PARP1_9425;NQO1_33055;NFKBIB_9308;MPC2_33219;LPL_32544;HSPD1_8849;HADH_8776;GSTM7_8761;GPX4_32827;GNL3_8735;GADD45B_8679;G0S2_32729;FABP7_8592;FABP1_33091;EXOSC5_32543;ERBB3_8571;EPHX2_33282;EIF4EBP1_8550;CYP2J4_32580;CYP17A1_32365;CHRNA2_32401;CD36_8243;BMF_8152;ANXA7_8051;ACOT1_7968;ACADM_7957;ACADL_32776;ACAA2_7955;ABCG2_32656 50.81810047619048 46.5095 27.86933642147609 34.8700280952381 34.0056 16.757176119492627 83.44545880952384 69.13454999999999 71.021505661035 52.0003;108.883;46.6406;45.1539;50.1846;2.38018;105.46;60.39;77.4407;26.4203;25.6517;50.0307;56.8931;26.9741;87.2765;30.5572;46.8463;74.2041;42.2579;33.3125;42.3152;45.9204;87.6357;106.367;46.3784;24.601;33.8478;41.9329;60.9984;38.7293;83.9001;17.8395;49.6922;49.3913;48.1296;94.8767;104.64;31.2018;11.7137;33.4878;26.5872;5.21654 38.9015;73.1414;28.5876;28.132;36.5009;0.56209;63.7532;43.109;58.7732;21.0125;20.9252;38.7717;45.1162;21.799;60.6992;24.2439;35.8494;49.8682;23.9469;25.7336;31.4035;34.2198;54.41;52.7132;33.7914;14.4402;26.4736;31.7336;41.6036;29.2097;42.4185;14.6501;35.6654;41.8524;37.5433;73.1342;43.9254;26.858;8.36151;26.6039;21.3695;2.73368 80.8613;138.144;63.7146;61.5341;80.9788;8.82917;422.699;104.942;89.8047;35.3561;33.0375;73.0083;81.5688;35.2797;197.117;41.2611;69.127;155.425;102.383;46.9856;64.5991;70.4292;238.963;109.434;73.6529;35.6155;46.9257;62.1373;113.972;57.2113;107.32;22.6149;81.6409;62.472;69.1421;109.848;108.689;37.2719;18.9642;45.3228;35.0407;11.386 63 79426;24522;308843;246273;25357;362895;170698;29573;29482;79224;24794;24648;252922;192280;83516;29441;303612;85253;25513;360722;25493;24567;24552;299282;307582;288001;58954;24516;81678;54404;50693;306251;25685;494344;192235;65164;24471;24464;25675;24957;29455;25112;294515;314322;25661;246186;361969;83928;24890;24330;116663;140942;25428;25423;113936;25695;114851;313421;79431;25698;25377;25373;25303 ZFP36_10204;ZFP354A_10203;TSKU_10094;TRIB3_10079;THRSP_33314;STAC3_9953;SLCO1A2_9886;SLC37A4_9871;SLC1A2_33059;SERPIND1_9812;SERPINA3C_32925;SERPINA1_9807;PZP_9633;PPP1R3B_9545;PPARGC1A_33189;POR_9531;POLG2_9521;PLG_9501;PIK3R1_32562;PDIA5_9451;NFKBIA_9307;MT1A_9255;ME1_9215;LOC299282_9119;LAMA3_8980;KNG1L1_34113;KLF6_8969;JUN_8938;ITPR2_8931;ITIH4_32725;ITIH3_32422;ITIH1_33132;IGFBP1_32306;IER2_32643;HYOU1_8857;HTRA1_8856;HSPB1_8847;HP_8823;HMGCR_8810;GLUL_32832;GDF15_33113;GADD45A_8678;FOXO3_8662;FOS_8657;FN1_8655;FGL1_8640;FGA_8632;FETUB_33027;ESR1_33192;EGR1_8533;DUSP6_8506;DDIT4_8450;CYP7A1_8430;CTSC_32456;CPB2_8369;CEBPD_8283;CDKN1A_8271;C8B_8181;BHLHE40_8141;ASS1_33159;AMBP_33085;AHSG_8003;ABCC2_32541 38.10188404761906 29.766 31.309794447111685 26.286334860317474 22.529 22.24904738920161 62.07017253968255 45.5481 49.20986346390174 0.348134;0.834827;1.38416;108.064;32.2053;63.2393;104.197;39.7166;13.3235;28.261;29.766;15.797;34.1871;36.1411;42.4094;12.4414;63.7758;70.7857;18.7324;107.066;0.520151;12.9315;80.7944;45.2017;2.46923;24.3655;18.9476;16.4324;31.8111;57.1163;27.1247;98.1741;49.0259;49.6814;40.1982;33.1323;89.1011;64.9285;1.63089;26.4669;105.149;102.919;13.1992;1.28141E-12;59.5777;15.4757;28.5803;32.5155;23.3972;0.750017;62.3934;87.5421;5.72128;56.2386;25.8316;0.306936;6.24967;21.3618;57.8085;26.8037;17.2343;12.402;46.2316 0.118102;0.27095;0.540568;83.8836;24.3966;42.7031;80.3101;22.6911;9.10952;22.307;23.347;13.013;26.3085;27.0588;26.2988;8.48981;40.9553;46.2356;11.6701;61.3361;0.160202;8.91033;59.856;30.7472;0.871501;19.538;11.6941;10.5224;24.7342;39.6402;21.5108;42.9071;32.6883;33.4626;29.3844;25.6145;60.3265;41.6103;0.663137;21.0456;85.3487;89.5012;5.6804;1.28141E-12;31.0499;10.2138;22.529;19.6094;18.3088;0.186019;39.0875;53.2453;0.985273;38.2681;20.4374;0.0732342;2.44025;17.2088;38.3491;20.9825;14.1233;10.3013;31.1788 1.15962;2.99857;4.10872;143.428;46.6068;121.52;128.412;60.0334;24.6773;38.3264;40.8256;19.9134;48.5666;53.6244;81.7305;79.2355;132.567;150.579;41.5978;114.259;2.88499;23.4636;94.0621;78.6415;10.4175;32.1467;45.5481;39.929;44.3296;101.869;36.4819;104.278;89.1623;89.4404;62.3571;46.6629;106.138;136.455;7.6286;35.4303;125.652;115.437;32.7581;1.28142E-12;105.243;30.4106;38.8511;49.9875;31.9156;4.70178;133.304;245.492;22.3625;102.888;34.8042;1.73689;19.0606;27.9161;110.58;36.7081;21.9073;15.4235;81.7848 0 Exp 2,41(0.4);Exp 3,5(0.05);Exp 4,6(0.06);Hill,9(0.09);Linear,21(0.2);Poly 2,20(0.2);Power,3(0.03) 2.0308566329192725 553.8645181655884 1.5074360370635986 344.14306640625 33.39525357187917 1.7521979808807373 37.355875606783 49.020865631312276 25.782757653401667 33.65686665516981 59.23510580737157 82.00546828786658 DOWN 0.4 0.6 0.0 GO:0051918 6 negative regulation of fibrinolysis 5 5 2 2 2 2 2 2 160 3 2382 0.9977 0.035397 0.035397 40.0 85253;113936 plg;cpb2 PLG_9501;CPB2_8369 48.30865 48.30865 25.8316 31.787348952138178 64.6911518612335 21.763796059933167 33.3365 33.3365 20.4374 18.242082162406785 42.73806870044052 12.489778763524809 92.69160000000001 92.69160000000001 34.8042 81.8651461705163 134.88309925110133 56.05048563044427 0.0 25.8316 0.0 25.8316 70.7857;25.8316 46.2356;20.4374 150.579;34.8042 0 2 0 2 85253;113936 PLG_9501;CPB2_8369 48.30865 48.30865 31.787348952138178 33.3365 33.3365 18.242082162406785 92.69160000000001 92.69160000000001 81.8651461705163 70.7857;25.8316 46.2356;20.4374 150.579;34.8042 0 Exp 2,1(0.5);Linear,1(0.5) 1.5441627703137897 3.088554620742798 1.5254690647125244 1.5630855560302734 0.026598876095225224 1.544277310371399 4.253632000000003 92.36366799999999 8.054264000000007 58.618736 -20.767703999999966 206.15090399999997 DOWN 0.0 1.0 0.0 GO:0002694 5 regulation of leukocyte activation 146 156 8 7 5 6 4 4 158 152 2233 0.023796 0.99221 0.041799 2.56 63868;246186;25423;114851 hspd1;fgl1;ctsc;cdkn1a HSPD1_8849;FGL1_8640;CTSC_32456;CDKN1A_8271 30.0554675 28.866799999999998 6.24967 23.19296877212772 27.54341269233116 23.177727434882186 18.717262499999997 17.08035 2.44025 15.777984300356358 17.251080766884268 15.815234711782503 63.68555 66.3968 19.0606 45.21405822127302 57.80106461472759 44.56008624920547 42.2579;15.4757;56.2386;6.24967 23.9469;10.2138;38.2681;2.44025 102.383;30.4106;102.888;19.0606 1 3 1 63868 HSPD1_8849 42.2579 42.2579 23.9469 23.9469 102.383 102.383 42.2579 23.9469 102.383 3 246186;25423;114851 FGL1_8640;CTSC_32456;CDKN1A_8271 25.987989999999996 15.4757 26.600835727835697 16.974050000000002 10.2138 18.84633768010379 50.78639999999999 30.4106 45.47678712178337 15.4757;56.2386;6.24967 10.2138;38.2681;2.44025 30.4106;102.888;19.0606 0 Exp 2,1(0.25);Exp 3,1(0.25);Exp 4,1(0.25);Poly 2,1(0.25) 1.689707990439878 6.858917832374573 1.511321783065796 2.2518506050109863 0.3591119492714483 1.5478727221488953 7.326358103314835 52.78457689668517 3.254837885650769 34.17968711434922 19.37577294315244 107.99532705684757 DOWN 0.25 0.75 0.0 GO:0010212 5 response to ionizing radiation 75 76 10 10 8 9 7 7 155 69 2316 0.89363 0.20573 0.33271 9.21 25591;24464;25112;361969;24330;25146;114851 parp1;hp;gadd45a;fga;egr1;cyp17a1;cdkn1a PARP1_9425;HP_8823;GADD45A_8678;FGA_8632;EGR1_8533;CYP17A1_32365;CDKN1A_8271 40.013398142857135 28.5803 0.750017 35.7162374768759 40.443320475130115 37.637702397429166 30.533024142857137 22.529 0.186019 30.212539743906508 31.283906436824083 32.21813528045926 61.632297142857155 38.8511 4.70178 50.266958332321934 60.88668730213391 51.480299942387965 2.5 27.7772 26.9741;64.9285;102.919;28.5803;0.750017;49.6922;6.24967 21.799;41.6103;89.5012;22.529;0.186019;35.6654;2.44025 35.2797;136.455;115.437;38.8511;4.70178;81.6409;19.0606 2 5 2 25591;25146 PARP1_9425;CYP17A1_32365 38.33315 38.33315 16.06412256567409 28.7322 28.7322 9.805025470645138 58.460300000000004 58.460300000000004 32.78231890394575 26.9741;49.6922 21.799;35.6654 35.2797;81.6409 5 24464;25112;361969;24330;114851 HP_8823;GADD45A_8678;FGA_8632;EGR1_8533;CDKN1A_8271 40.685497399999996 28.5803 42.97655357436818 31.253353800000003 22.529 36.64548578242956 62.90109600000001 38.8511 59.28269094502272 64.9285;102.919;28.5803;0.750017;6.24967 41.6103;89.5012;22.529;0.186019;2.44025 136.455;115.437;38.8511;4.70178;19.0606 0 Exp 2,2(0.29);Exp 4,1(0.15);Hill,1(0.15);Linear,2(0.29);Poly 2,1(0.15) 1.905640596377798 14.26794707775116 1.522104263305664 4.21828556060791 0.9714085640602123 1.6339634656906128 13.554439146250317 66.47235713946397 8.15126148420827 52.91478680150602 24.39401328778556 98.87058099792873 DOWN 0.2857142857142857 0.7142857142857143 0.0 GO:0007599 5 hemostasis 28 29 7 7 7 7 7 7 155 22 2363 0.99969 0.0017517 0.0017517 24.14 79224;85253;294103;361969;304929;113936;155423 serpind1;plg;papss2;fga;f5;cpb2;anxa7 SERPIND1_9812;PLG_9501;PAPSS2_33237;FGA_8632;F5_33079;CPB2_8369;ANXA7_8051 43.307399999999994 28.5803 10.6089 32.693466346555155 51.07797571175239 32.684990658951364 26.249241428571427 22.529 2.59129 14.916656780905956 31.046412250523936 14.068268971182313 65.69412857142858 38.8511 34.8042 45.61641818704879 79.46229213283895 52.075152885524986 0.5 18.22025 1.5 27.046300000000002 28.261;70.7857;34.4443;28.5803;10.6089;25.8316;104.64 22.307;46.2356;25.719;22.529;2.59129;20.4374;43.9254 38.3264;150.579;51.1014;38.8511;37.5078;34.8042;108.689 1 6 1 155423 ANXA7_8051 104.64 104.64 43.9254 43.9254 108.689 108.689 104.64 43.9254 108.689 6 79224;85253;294103;361969;304929;113936 SERPIND1_9812;PLG_9501;PAPSS2_33237;FGA_8632;F5_33079;CPB2_8369 33.0853 28.420650000000002 20.122329175818603 23.303214999999998 22.418 13.932113156063226 58.528316666666676 38.588750000000005 45.44995823674281 28.261;70.7857;34.4443;28.5803;10.6089;25.8316 22.307;46.2356;25.719;22.529;2.59129;20.4374 38.3264;150.579;51.1014;38.8511;37.5078;34.8042 0 Exp 2,2(0.29);Exp 3,1(0.15);Hill,1(0.15);Linear,3(0.43) 1.6057016314078152 11.259753465652466 1.5254690647125244 1.8057876825332642 0.10536908756983758 1.5630855560302734 19.087741194099586 67.52705880590042 15.198827442832341 37.299655414310514 31.9010130685812 99.48724407427596 DOWN 0.14285714285714285 0.8571428571428571 0.0 GO:0120178 6 steroid hormone biosynthetic process 11 13 3 3 3 2 2 2 160 11 2374 0.95495 0.19842 0.19842 15.38 29540;25146 hsd17b7;cyp17a1 HSD17B7_8834;CYP17A1_32365 25.334847 25.334847 0.977494 34.446498956109 24.562002117503486 34.429154969421134 17.994041 17.994041 0.322682 24.99107556336385 17.43333888389121 24.978492430243747 43.56781 43.56781 5.49472 53.84348023945146 42.359772625523014 53.81636977444626 0.0 0.977494 0.5 25.334847 0.977494;49.6922 0.322682;35.6654 5.49472;81.6409 1 1 1 25146 CYP17A1_32365 49.6922 49.6922 35.6654 35.6654 81.6409 81.6409 49.6922 35.6654 81.6409 1 29540 HSD17B7_8834 0.977494 0.977494 0.322682 0.322682 5.49472 5.49472 0.977494 0.322682 5.49472 0 Exp 4,1(0.5);Linear,1(0.5) 1.8147926392239164 3.634273409843445 1.7248681783676147 1.90940523147583 0.13048740163300113 1.8171367049217224 -22.405564880000004 73.07525888 -16.641822639999997 52.62990463999999 -31.055446399999987 118.19106639999998 CONFLICT 0.5 0.5 0.0 GO:0052695 9 cellular glucuronidation 3 10 2 2 2 2 2 2 160 8 2377 0.97825 0.12934 0.12934 20.0 286954;501907 ugt2b1;rgd1559459 UGT2B10_33303,UGT2B1_33224;RGD1559459_9690 23.736725000000128 23.736725000000128 2.52378E-13 33.568798421320324 36.23269625098664 28.540596217323046 17.414575000000127 17.414575000000127 2.52378E-13 24.627928147963257 26.58231101026051 20.93896076106909 38.23737500000013 38.23737500000013 2.52379E-13 54.075814314545745 58.36707438831891 45.97590780890648 0.0 2.52378E-13 0.0 2.52378E-13 47.47345;2.52378E-13 34.82915;2.52378E-13 76.47475;2.52379E-13 2 1 1 286954 UGT2B10_33303,UGT2B1_33224 47.47345 47.47345 34.82915 34.82915 76.47475 76.47475 47.47345 34.82915 76.47475 1 501907 RGD1559459_9690 2.52378E-13 2.52378E-13 2.52378E-13 2.52378E-13 2.52379E-13 2.52379E-13 2.52378E-13 2.52378E-13 2.52379E-13 0 Exp 2,2(0.67);Hill,1(0.34) 1.6758602064412427 5.031708121299744 1.6167030334472656 1.7730062007904053 0.08389822860854793 1.6419988870620728 -22.787255999999616 70.26070599999987 -16.71799199999962 51.54714199999987 -36.70787999999962 113.18262999999988 CONFLICT 0.5 0.5 0.0 GO:0007274 8 neuromuscular synaptic transmission 6 6 2 2 2 2 2 2 160 4 2381 0.99562 0.050905 0.050905 33.33 362895;170945 stac3;chrna2 STAC3_9953;CHRNA2_32401 56.3153 56.3153 49.3913 9.792014705871322 54.671948694908 9.512220822505425 42.27775 42.27775 41.8524 0.6015357387554296 42.17679686920553 0.5843476497482601 91.996 91.996 62.472 41.753241215503294 84.98873484524319 40.56019751063673 0.0 49.3913 0.0 49.3913 63.2393;49.3913 42.7031;41.8524 121.52;62.472 1 1 1 170945 CHRNA2_32401 49.3913 49.3913 41.8524 41.8524 62.472 62.472 49.3913 41.8524 62.472 1 362895 STAC3_9953 63.2393 63.2393 42.7031 42.7031 121.52 121.52 63.2393 42.7031 121.52 0 Exp 2,1(0.5);Linear,1(0.5) 2.692843095884814 5.397742033004761 2.5185911655426025 2.879150867462158 0.25495421024991805 2.6988710165023804 42.744260000000004 69.88634 41.444064000000004 43.11143599999999 34.12896000000001 149.86303999999998 CONFLICT 0.5 0.5 0.0 GO:0007409 9 axonogenesis 28 30 2 2 2 2 2 2 160 28 2357 0.70272 0.57847 0.7161 6.67 308843;29496 tsku;erbb3 TSKU_10094;ERBB3_8571 31.19128 31.19128 1.38416 42.153633359282324 46.19847583262169 36.42110585733889 21.072084 21.072084 0.540568 29.0359483832802 31.409227654019766 25.087311945858797 59.04036 59.04036 4.10872 77.68507029139639 86.69717081859216 67.12057640447082 0.5 31.19128 1.38416;60.9984 0.540568;41.6036 4.10872;113.972 1 1 1 29496 ERBB3_8571 60.9984 60.9984 41.6036 41.6036 113.972 113.972 60.9984 41.6036 113.972 1 308843 TSKU_10094 1.38416 1.38416 0.540568 0.540568 4.10872 4.10872 1.38416 0.540568 4.10872 0 Hill,1(0.5);Linear,1(0.5) 2.182411933513177 4.575707197189331 1.6013026237487793 2.9744045734405518 0.970929699887522 2.2878535985946655 -27.230675199999993 89.61323519999999 -19.16968736 61.313855360000005 -48.6256544 166.7063744 CONFLICT 0.5 0.5 0.0 GO:0030155 5 regulation of cell adhesion 210 219 17 17 12 14 11 11 151 208 2177 0.24651 0.83998 0.47002 5.02 85253;25513;307582;288001;63868;25661;246186;361969;29496;29184;25698 plg;pik3r1;lama3;kng1;hspd1;fn1;fgl1;fga;erbb3;cd36;ass1 PLG_9501;PIK3R1_32562;LAMA3_8980;KNG1L1_34113;HSPD1_8849;FN1_8655;FGL1_8640;FGA_8632;ERBB3_8571;CD36_8243;ASS1_33159 36.19783 28.5803 2.46923 21.66897731362742 40.6976630798991 20.866617072485873 24.19856372727273 22.529 0.871501 13.947012667346817 26.882423895598322 13.171662258895598 66.49553636363636 41.5978 10.4175 44.741969779397785 74.18030639277818 43.9906531867705 9.5 65.89205 70.7857;18.7324;2.46923;24.3655;42.2579;59.5777;15.4757;28.5803;60.9984;48.1296;26.8037 46.2356;11.6701;0.871501;19.538;23.9469;31.0499;10.2138;22.529;41.6036;37.5433;20.9825 150.579;41.5978;10.4175;32.1467;102.383;105.243;30.4106;38.8511;113.972;69.1421;36.7081 3 8 3 63868;29496;29184 HSPD1_8849;ERBB3_8571;CD36_8243 50.46196666666666 48.1296 9.585485682182902 34.3646 37.5433 9.247586927950449 95.1657 102.383 23.270089126816867 42.2579;60.9984;48.1296 23.9469;41.6036;37.5433 102.383;113.972;69.1421 8 85253;25513;307582;288001;25661;246186;361969;25698 PLG_9501;PIK3R1_32562;LAMA3_8980;KNG1L1_34113;FN1_8655;FGL1_8640;FGA_8632;ASS1_33159 30.84877875 25.584600000000002 22.904731663134232 20.386300125 20.26025 13.876208749255477 55.744225 37.7796 47.1241280091435 70.7857;18.7324;2.46923;24.3655;59.5777;15.4757;28.5803;26.8037 46.2356;11.6701;0.871501;19.538;31.0499;10.2138;22.529;20.9825 150.579;41.5978;10.4175;32.1467;105.243;30.4106;38.8511;36.7081 0 Exp 2,2(0.19);Exp 3,1(0.1);Exp 4,1(0.1);Linear,4(0.37);Poly 2,2(0.19);Power,1(0.1) 1.8301494837587826 20.507022857666016 1.511321783065796 2.6703107357025146 0.39407373006673724 1.6902168989181519 23.392282728504547 49.003377271495445 15.956405944610031 32.440721509935415 40.05472188783834 92.93635083943441 DOWN 0.2727272727272727 0.7272727272727273 0.0 GO:0030154 4 cell differentiation 405 432 43 43 32 38 29 29 133 403 1982 0.67519 0.40478 0.74557 6.71 24825;29573;246074;297784;83516;85253;363465;25513;81819;307582;24516;494344;65164;29540;25675;314322;25661;80841;24890;29496;24330;116663;140942;25146;497840;25695;79431;155423;24158 tf;slc37a4;scd;rrs1;ppargc1a;plg;pir;pik3r1;pax8;lama3;jun;ier2;htra1;hsd17b7;hmgcr;fos;fn1;fabp7;esr1;erbb3;egr1;dusp6;ddit4;cyp17a1;cps1;cebpd;bhlhe40;anxa7;acadm TF_10003;SLC37A4_9871;SCD1_9787;RRS1_9755;PPARGC1A_33189;PLG_9501;PIR_9487;PIK3R1_32562;PAX8_9432;LAMA3_8980;JUN_8938;IER2_32643;HTRA1_8856;HSD17B7_8834;HMGCR_8810;FOS_8657;FN1_8655;FABP7_8592;ESR1_33192;ERBB3_8571;EGR1_8533;DUSP6_8506;DDIT4_8450;CYP17A1_32365;CPS1_32421;CEBPD_8283;BHLHE40_8141;ANXA7_8051;ACADM_7957 40.320664379310394 42.4094 1.28141E-12 30.40485372772548 44.2061862194127 27.542744596873526 25.724623558620735 26.2988 1.28141E-12 18.2966198894708 28.32391780231106 16.539198983729776 79.81758586206901 61.5341 1.28142E-12 85.54823848561051 81.94653041655673 74.5179390377445 20.5 58.6931 45.1539;39.7166;105.46;60.39;42.4094;70.7857;50.0307;18.7324;56.8931;2.46923;16.4324;49.6814;33.1323;0.977494;1.63089;1.28141E-12;59.5777;24.601;23.3972;60.9984;0.750017;62.3934;87.5421;49.6922;31.9826;0.306936;57.8085;104.64;11.7137 28.132;22.6911;63.7532;43.109;26.2988;46.2356;38.7717;11.6701;45.1162;0.871501;10.5224;33.4626;25.6145;0.322682;0.663137;1.28141E-12;31.0499;14.4402;18.3088;41.6036;0.186019;39.0875;53.2453;35.6654;24.4836;0.0732342;38.3491;43.9254;8.36151 61.5341;60.0334;422.699;104.942;81.7305;150.579;73.0083;41.5978;81.5688;10.4175;39.929;89.4404;46.6629;5.49472;7.6286;1.28142E-12;105.243;35.6155;31.9156;113.972;4.70178;133.304;245.492;81.6409;45.5891;1.73689;110.58;108.689;18.9642 10 19 10 24825;246074;297784;363465;81819;80841;29496;25146;155423;24158 TF_10003;SCD1_9787;RRS1_9755;PIR_9487;PAX8_9432;FABP7_8592;ERBB3_8571;CYP17A1_32365;ANXA7_8051;ACADM_7957 56.9573 53.4619 29.792361128502574 36.287821 40.187650000000005 15.971077296474569 110.26338000000001 81.60485 114.0046400223332 45.1539;105.46;60.39;50.0307;56.8931;24.601;60.9984;49.6922;104.64;11.7137 28.132;63.7532;43.109;38.7717;45.1162;14.4402;41.6036;35.6654;43.9254;8.36151 61.5341;422.699;104.942;73.0083;81.5688;35.6155;113.972;81.6409;108.689;18.9642 19 29573;83516;85253;25513;307582;24516;494344;65164;29540;25675;314322;25661;24890;24330;116663;140942;497840;25695;79431 SLC37A4_9871;PPARGC1A_33189;PLG_9501;PIK3R1_32562;LAMA3_8980;JUN_8938;IER2_32643;HTRA1_8856;HSD17B7_8834;HMGCR_8810;FOS_8657;FN1_8655;ESR1_33192;EGR1_8533;DUSP6_8506;DDIT4_8450;CPS1_32421;CEBPD_8283;BHLHE40_8141 31.56454036842112 31.9826 27.56001503515089 20.1650459578948 22.6911 17.27988238099297 63.7934836842106 45.5891 64.02967217354679 39.7166;42.4094;70.7857;18.7324;2.46923;16.4324;49.6814;33.1323;0.977494;1.63089;1.28141E-12;59.5777;23.3972;0.750017;62.3934;87.5421;31.9826;0.306936;57.8085 22.6911;26.2988;46.2356;11.6701;0.871501;10.5224;33.4626;25.6145;0.322682;0.663137;1.28141E-12;31.0499;18.3088;0.186019;39.0875;53.2453;24.4836;0.0732342;38.3491 60.0334;81.7305;150.579;41.5978;10.4175;39.929;89.4404;46.6629;5.49472;7.6286;1.28142E-12;105.243;31.9156;4.70178;133.304;245.492;45.5891;1.73689;110.58 0 Exp 2,10(0.35);Exp 3,1(0.04);Exp 4,3(0.11);Hill,4(0.14);Linear,5(0.18);Poly 2,5(0.18);Power,1(0.04) 1.85359798876754 54.94792604446411 1.5254690647125244 4.21828556060791 0.49601891506870754 1.7647881507873535 29.25442677273059 51.38690198589021 19.06533340359111 32.38391371365035 48.681204073037435 110.95396765110061 DOWN 0.3448275862068966 0.6551724137931034 0.0 GO:0043085 5 positive regulation of catalytic activity 340 363 27 27 21 24 18 18 144 345 2040 0.14227 0.9062 0.29509 4.96 246273;24825;29573;293615;25106;29441;303612;24516;63868;29455;299626;25112;25661;24360;24890;29496;24330;114851 trib3;tf;slc37a4;sirt3;rgn;por;polg2;jun;hspd1;gdf15;gadd45b;gadd45a;fn1;fabp1;esr1;erbb3;egr1;cdkn1a TRIB3_10079;TF_10003;SLC37A4_9871;SIRT3_9828;RGN_9699;POR_9531;POLG2_9521;JUN_8938;HSPD1_8849;GDF15_33113;GADD45B_8679;GADD45A_8678;FN1_8655;FABP1_33091;ESR1_33192;ERBB3_8571;EGR1_8533;CDKN1A_8271 50.38437038888888 43.7059 0.750017 37.45256556458035 49.722115451195776 36.61211509256977 34.754537166666665 27.3028 0.186019 29.002739780010632 34.95175006060059 30.227825369937932 77.22697499999998 84.5201 4.70178 44.353746524070935 77.36114209942183 43.37288043708826 108.064;45.1539;39.7166;2.38018;77.4407;12.4414;63.7758;16.4324;42.2579;105.149;106.367;102.919;59.5777;33.8478;23.3972;60.9984;0.750017;6.24967 83.8836;28.132;22.6911;0.56209;58.7732;8.48981;40.9553;10.5224;23.9469;85.3487;52.7132;89.5012;31.0499;26.4736;18.3088;41.6036;0.186019;2.44025 143.428;61.5341;60.0334;8.82917;89.8047;79.2355;132.567;39.929;102.383;125.652;109.434;115.437;105.243;46.9257;31.9156;113.972;4.70178;19.0606 7 11 7 24825;293615;25106;63868;299626;24360;29496 TF_10003;SIRT3_9828;RGN_9699;HSPD1_8849;GADD45B_8679;FABP1_33091;ERBB3_8571 52.63512571428572 45.1539 33.2027958527385 33.17208428571429 28.132 19.694122135671048 76.12609571428571 89.8047 38.757201172545074 45.1539;2.38018;77.4407;42.2579;106.367;33.8478;60.9984 28.132;0.56209;58.7732;23.9469;52.7132;26.4736;41.6036 61.5341;8.82917;89.8047;102.383;109.434;46.9257;113.972 11 246273;29573;29441;303612;24516;29455;25112;25661;24890;24330;114851 TRIB3_10079;SLC37A4_9871;POR_9531;POLG2_9521;JUN_8938;GDF15_33113;GADD45A_8678;FN1_8655;ESR1_33192;EGR1_8533;CDKN1A_8271 48.95207154545455 39.7166 41.4405934491229 35.76155263636363 22.6911 34.559900012832045 77.92753454545455 79.2355 49.413283739329934 108.064;39.7166;12.4414;63.7758;16.4324;105.149;102.919;59.5777;23.3972;0.750017;6.24967 83.8836;22.6911;8.48981;40.9553;10.5224;85.3487;89.5012;31.0499;18.3088;0.186019;2.44025 143.428;60.0334;79.2355;132.567;39.929;125.652;115.437;105.243;31.9156;4.70178;19.0606 0 Exp 2,3(0.17);Exp 3,1(0.06);Exp 4,1(0.06);Hill,2(0.12);Linear,1(0.06);Poly 2,8(0.45);Power,2(0.12) 1.8688134709033064 34.78934025764465 1.5209722518920898 4.21828556060791 0.6248343163093625 1.806852400302887 33.08216784097052 67.68657293680727 21.355954971996212 48.15311936133712 56.73658950704278 97.71736049295718 DOWN 0.3888888888888889 0.6111111111111112 0.0 GO:0022409 7 positive regulation of cell-cell adhesion 88 92 4 4 2 4 2 2 160 90 2295 0.059612 0.98417 0.12354 2.17 63868;361969 hspd1;fga HSPD1_8849;FGA_8632 35.4191 35.4191 28.5803 9.671523710357123 34.053664905857744 9.476789798627413 23.237949999999998 23.237949999999998 22.529 1.0026067050445762 23.09640101333682 0.9824194489876443 70.61705 70.61705 38.8511 44.92383731166558 64.27465909388076 44.019306150744235 42.2579;28.5803 23.9469;22.529 102.383;38.8511 1 1 1 63868 HSPD1_8849 42.2579 42.2579 23.9469 23.9469 102.383 102.383 42.2579 23.9469 102.383 1 361969 FGA_8632 28.5803 28.5803 22.529 22.529 38.8511 38.8511 28.5803 22.529 38.8511 0 Exp 3,1(0.5);Linear,1(0.5) 1.8633623210753631 3.7937464714050293 1.541895866394043 2.2518506050109863 0.5020138100115635 1.8968732357025146 22.015052000000004 48.823147999999996 21.848408 24.627491999999997 8.355788000000018 132.878312 CONFLICT 0.5 0.5 0.0 GO:0042752 4 regulation of circadian rhythm 33 35 2 2 2 2 2 2 160 33 2352 0.61347 0.66341 1.0 5.71 83516;79431 ppargc1a;bhlhe40 PPARGC1A_33189;BHLHE40_8141 50.10895 50.10895 42.4094 10.888808034169793 46.41551889827101 9.55422805874766 32.323949999999996 32.323949999999996 26.2988 8.520848845332267 29.433719219943708 7.4764963131824445 96.15525 96.15525 81.7305 20.39967708384141 89.23577804583837 17.899403366485114 0.5 50.10895 42.4094;57.8085 26.2988;38.3491 81.7305;110.58 0 2 0 2 83516;79431 PPARGC1A_33189;BHLHE40_8141 50.10895 50.10895 10.888808034169793 32.323949999999996 32.323949999999996 8.520848845332267 96.15525 96.15525 20.39967708384141 42.4094;57.8085 26.2988;38.3491 81.7305;110.58 0 Exp 2,2(1) 1.7304625031118706 3.4613447189331055 1.7037216424942017 1.7576230764389038 0.03811406945797765 1.7306723594665527 35.017832 65.200068 20.514656 44.13324399999999 67.88274000000001 124.42775999999998 DOWN 0.0 1.0 0.0 GO:0045785 6 positive regulation of cell adhesion 137 145 9 9 4 7 4 4 158 141 2244 0.038827 0.9864 0.07761 2.76 63868;25661;361969;29184 hspd1;fn1;fga;cd36 HSPD1_8849;FN1_8655;FGA_8632;CD36_8243 44.636375 45.19375 28.5803 12.895742209317246 45.15290786427965 13.57486601465874 28.767275 27.4984 22.529 6.93736457663619 29.178604020041607 6.934078288487793 78.9048 85.76255 38.8511 31.329091110659437 77.4675084092707 31.724555794986838 42.2579;59.5777;28.5803;48.1296 23.9469;31.0499;22.529;37.5433 102.383;105.243;38.8511;69.1421 2 2 2 63868;29184 HSPD1_8849;CD36_8243 45.19375 45.19375 4.151918887092963 30.7451 30.7451 9.61410663972478 85.76255 85.76255 23.504865802743858 42.2579;48.1296 23.9469;37.5433 102.383;69.1421 2 25661;361969 FN1_8655;FGA_8632 44.079 44.079 21.918471739151887 26.789450000000002 26.789450000000002 6.025186171812455 72.04705 72.04705 46.94616270585912 59.5777;28.5803 31.0499;22.529 105.243;38.8511 0 Exp 2,1(0.25);Exp 3,1(0.25);Linear,1(0.25);Power,1(0.25) 2.015335460302313 8.243290781974792 1.541895866394043 2.6703107357025146 0.5021768679747303 2.0155420899391174 31.99854763486909 57.27420236513091 21.96865771489653 35.56589228510347 48.20229071155376 109.60730928844623 CONFLICT 0.5 0.5 0.0 GO:0019395 7 fatty acid oxidation 39 43 24 24 17 23 16 16 146 27 2358 1.0 2.0482E-9 2.0482E-9 37.21 65192;83516;29441;171155;113965;85255;295143;171142;291075;29740;83842;29184;50681;24158;25287;170465 slc27a2;ppargc1a;por;hadhb;hadh;hacl1;etfdh;ehhadh;eci2;eci1;crot;cd36;acox1;acadm;acadl;acaa2 SLC27A2_9860;PPARGC1A_33189;POR_9531;HADHB_8777;HADH_8776;HACL1_8775;ETFDH_8575;EHHADH_8534;ECI2_8521;ECI1_8520;CROT_8384;CD36_8243;ACOX1_7973;ACADM_7957;ACADL_32776;ACAA2_7955 21.568286249999996 17.875300000000003 7.4229 12.997755037823977 22.302838483627994 14.278781743774136 16.06081625 13.032 5.49916 9.851970842567408 16.689082933940107 10.756186049160346 36.17786875 34.247299999999996 10.316 23.68523817156216 38.153970783495375 25.49919825858353 1.5 8.12499 3.5 11.1802 7.62189;42.4094;12.4414;31.8029;33.3125;17.6275;18.1231;8.62809;10.6467;11.9473;7.4229;48.1296;23.1906;11.7137;33.4878;26.5872 5.49916;26.2988;8.48981;25.5756;25.7336;11.195;14.869;7.31865;8.92359;7.15307;5.75707;37.5433;16.2815;8.36151;26.6039;21.3695 13.3925;81.7305;79.2355;42.1484;46.9856;37.6534;23.0103;10.3909;13.0581;19.001;10.316;69.1421;33.4539;18.9642;45.3228;35.0407 14 2 14 65192;171155;113965;85255;295143;171142;291075;29740;83842;29184;50681;24158;25287;170465 SLC27A2_9860;HADHB_8777;HADH_8776;HACL1_8775;ETFDH_8575;EHHADH_8534;ECI2_8521;ECI1_8520;CROT_8384;CD36_8243;ACOX1_7973;ACADM_7957;ACADL_32776;ACAA2_7955 20.731555714285715 17.875300000000003 12.424141553804844 15.87031785714286 13.032 9.974102775964884 29.848564285714286 28.2321 17.375965841383724 7.62189;31.8029;33.3125;17.6275;18.1231;8.62809;10.6467;11.9473;7.4229;48.1296;23.1906;11.7137;33.4878;26.5872 5.49916;25.5756;25.7336;11.195;14.869;7.31865;8.92359;7.15307;5.75707;37.5433;16.2815;8.36151;26.6039;21.3695 13.3925;42.1484;46.9856;37.6534;23.0103;10.3909;13.0581;19.001;10.316;69.1421;33.4539;18.9642;45.3228;35.0407 2 83516;29441 PPARGC1A_33189;POR_9531 27.4254 27.4254 21.190576018598453 17.394305 17.394305 12.592857595083418 80.483 80.483 1.764231419060398 42.4094;12.4414 26.2988;8.48981 81.7305;79.2355 0 Exp 2,6(0.38);Hill,2(0.13);Linear,3(0.19);Poly 2,4(0.25);Power,1(0.07) 3.1501994742003285 82.5651603937149 1.693061113357544 32.73371124267578 7.876513205658145 2.2722251415252686 15.199386281466255 27.937186218533746 11.23335053714197 20.888281962858027 24.57210204593454 47.78363545406545 UP 0.875 0.125 0.0 GO:0032642 6 regulation of chemokine production 31 34 3 3 3 3 3 3 159 31 2354 0.83336 0.36878 0.47423 8.82 29573;24539;24330 slc37a4;lpl;egr1 SLC37A4_9871;LPL_32544;EGR1_8533 38.22357233333333 39.7166 0.750017 36.74979491171068 42.31124958830455 36.175705799165705 24.248439666666666 22.6911 0.186019 24.877675883354147 26.998615171507062 24.708245795372314 73.38672666666668 60.0334 4.70178 76.24372604740756 81.680962299843 76.45921141061987 0.5 20.2333085 39.7166;74.2041;0.750017 22.6911;49.8682;0.186019 60.0334;155.425;4.70178 1 2 1 24539 LPL_32544 74.2041 74.2041 49.8682 49.8682 155.425 155.425 74.2041 49.8682 155.425 2 29573;24330 SLC37A4_9871;EGR1_8533 20.2333085 20.2333085 27.55353507896844 11.4385595 11.4385595 15.913495386252526 32.36759 32.36759 39.1253637160372 39.7166;0.750017 22.6911;0.186019 60.0334;4.70178 0 Exp 2,1(0.34);Hill,1(0.34);Poly 2,1(0.34) 2.3180671907739216 7.671269655227661 1.559399127960205 4.21828556060791 1.4483087888988024 1.893584966659546 -3.362735477148476 79.80988014381515 -3.903300754744212 52.40018008807755 -12.891171418015375 159.66462475134873 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0006974 5 cellular response to DNA damage stimulus 142 151 11 11 10 8 7 7 155 144 2241 0.24139 0.85936 0.4905 4.64 303612;25513;25591;25112;294515;140942;114851 polg2;pik3r1;parp1;gadd45a;foxo3;ddit4;cdkn1a POLG2_9521;PIK3R1_32562;PARP1_9425;GADD45A_8678;FOXO3_8662;DDIT4_8450;CDKN1A_8271 45.62746714285714 26.9741 6.24967 38.82012864966949 46.09503838226417 41.8213081089037 32.184507142857136 21.799 2.44025 31.415429517601016 35.54403153981233 36.36685293629532 88.88459999999999 41.5978 19.0606 81.92899515920274 72.73026024803819 64.51988932280629 63.7758;18.7324;26.9741;102.919;13.1992;87.5421;6.24967 40.9553;11.6701;21.799;89.5012;5.6804;53.2453;2.44025 132.567;41.5978;35.2797;115.437;32.7581;245.492;19.0606 1 6 1 25591 PARP1_9425 26.9741 26.9741 21.799 21.799 35.2797 35.2797 26.9741 21.799 35.2797 6 303612;25513;25112;294515;140942;114851 POLG2_9521;PIK3R1_32562;GADD45A_8678;FOXO3_8662;DDIT4_8450;CDKN1A_8271 48.73636166666666 41.254099999999994 41.559775922240206 33.915425 26.3127 34.04626279716689 97.81875000000001 78.5174 85.93225467242785 63.7758;18.7324;102.919;13.1992;87.5421;6.24967 40.9553;11.6701;89.5012;5.6804;53.2453;2.44025 132.567;41.5978;115.437;32.7581;245.492;19.0606 0 Exp 2,2(0.29);Exp 4,2(0.29);Linear,1(0.15);Poly 2,2(0.29) 1.685795669075203 11.844330072402954 1.522104263305664 1.9883413314819336 0.16054665045727914 1.6672165393829346 16.869113387100583 74.3858208986137 8.911631269379107 55.45738301633518 28.190751020133767 149.57844897986624 DOWN 0.14285714285714285 0.8571428571428571 0.0 GO:0043433 8 negative regulation of DNA-binding transcription factor activity 32 34 6 6 5 5 4 4 158 30 2355 0.93913 0.16664 0.27209 11.76 81525;25493;24890;79431 nfkbib;nfkbia;esr1;bhlhe40 NFKBIB_9308;NFKBIA_9307;ESR1_33192;BHLHE40_8141 28.07076275 26.977200000000003 0.520151 23.60362813584422 30.683067424246776 16.05996054547022 20.2655005 21.27635 0.160202 15.820829498678876 23.242546096700146 10.637837009689925 46.660422499999996 36.58835 2.88499 45.63830026179063 46.201638849354374 32.49818901516853 0.5 11.9586755 2.5 44.18285 30.5572;0.520151;23.3972;57.8085 24.2439;0.160202;18.3088;38.3491 41.2611;2.88499;31.9156;110.58 1 3 1 81525 NFKBIB_9308 30.5572 30.5572 24.2439 24.2439 41.2611 41.2611 30.5572 24.2439 41.2611 3 25493;24890;79431 NFKBIA_9307;ESR1_33192;BHLHE40_8141 27.241950333333335 23.3972 28.837047553983407 18.939367333333333 18.3088 19.102256253778016 48.46019666666666 31.9156 55.721149969038095 0.520151;23.3972;57.8085 0.160202;18.3088;38.3491 2.88499;31.9156;110.58 0 Exp 2,3(0.75);Exp 4,1(0.25) 1.852736559230824 7.525524854660034 1.5302108526229858 2.436986207962036 0.39340282973918406 1.779163897037506 4.939207176872664 51.202318323127336 4.7610875912947055 35.7699134087053 1.9348882434451866 91.3859567565548 DOWN 0.25 0.75 0.0 GO:1901215 7 negative regulation of neuron death 102 106 10 10 8 9 7 7 155 99 2286 0.6395 0.51725 0.83921 6.6 83516;24567;24516;192235;63868;24890;29496 ppargc1a;mt1;jun;hyou1;hspd1;esr1;erbb3 PPARGC1A_33189;MT1A_9255;JUN_8938;HYOU1_8857;HSPD1_8849;ESR1_33192;ERBB3_8571 34.089285714285715 40.1982 12.9315 17.180939210108065 39.5856479889534 16.702801847227573 22.710747142857144 23.9469 8.91033 11.359754888577353 25.707032786078454 11.357727666753908 65.10725714285714 62.3571 23.4636 35.428248108717675 78.53121281334087 33.66756708964395 4.5 42.33365 42.4094;12.9315;16.4324;40.1982;42.2579;23.3972;60.9984 26.2988;8.91033;10.5224;29.3844;23.9469;18.3088;41.6036 81.7305;23.4636;39.929;62.3571;102.383;31.9156;113.972 2 5 2 63868;29496 HSPD1_8849;ERBB3_8571 51.62815 51.62815 13.251534632826507 32.77525 32.77525 12.48517230337651 108.1775 108.1775 8.194660487170758 42.2579;60.9984 23.9469;41.6036 102.383;113.972 5 83516;24567;24516;192235;24890 PPARGC1A_33189;MT1A_9255;JUN_8938;HYOU1_8857;ESR1_33192 27.073739999999997 23.3972 13.54798816717819 18.684946 18.3088 9.148235480057343 47.87916 39.929 23.82059942807905 42.4094;12.9315;16.4324;40.1982;23.3972 26.2988;8.91033;10.5224;29.3844;18.3088 81.7305;23.4636;39.929;62.3571;31.9156 0 Exp 2,3(0.43);Exp 3,1(0.15);Linear,1(0.15);Poly 2,2(0.29) 1.9690751544306473 13.951743841171265 1.6013026237487793 2.436986207962036 0.3336665374249274 1.9785058498382568 21.361467830955675 46.817103597615755 14.295322953705885 31.126171332008404 38.86164365579596 91.35287062991831 DOWN 0.2857142857142857 0.7142857142857143 0.0 GO:0090304 5 nucleic acid metabolic process 251 278 18 17 15 17 14 14 148 264 2121 0.20629 0.86356 0.43365 5.04 79426;297784;303612;81819;25591;24516;364070;63868;499914;294515;314322;308441;24890;24330 zfp36;rrs1;polg2;pax8;parp1;jun;iars2;hspd1;gins1;foxo3;fos;exosc5;esr1;egr1 ZFP36_10204;RRS1_9755;POLG2_9521;PAX8_9432;PARP1_9425;JUN_8938;IARS2_8858;HSPD1_8849;GINS1_8707;FOXO3_8662;FOS_8657;EXOSC5_32543;ESR1_33192;EGR1_8533 30.71411792857152 25.852249999999998 1.28141E-12 23.355008216801853 36.22465055684786 23.795233973399455 21.857044357142946 20.80055 1.28141E-12 17.117157407429097 26.149645686727663 17.79804336496573 53.84911428571438 37.60435 1.28142E-12 42.4676086394631 62.65022189910282 42.22082688088011 12.5 62.082899999999995 0.348134;60.39;63.7758;56.8931;26.9741;16.4324;24.7304;42.2579;58.9165;13.1992;1.28141E-12;41.9329;23.3972;0.750017 0.118102;43.109;40.9553;45.1162;21.799;10.5224;19.8021;23.9469;44.7208;5.6804;1.28141E-12;31.7336;18.3088;0.186019 1.15962;104.942;132.567;81.5688;35.2797;39.929;32.7087;102.383;91.837;32.7581;1.28142E-12;62.1373;31.9156;4.70178 7 7 7 297784;81819;25591;364070;63868;499914;308441 RRS1_9755;PAX8_9432;PARP1_9425;IARS2_8858;HSPD1_8849;GINS1_8707;EXOSC5_32543 44.584985714285715 42.2579 14.851920255467377 32.88965714285714 31.7336 11.324718254310945 72.9795 81.5688 30.210688375584333 60.39;56.8931;26.9741;24.7304;42.2579;58.9165;41.9329 43.109;45.1162;21.799;19.8021;23.9469;44.7208;31.7336 104.942;81.5688;35.2797;32.7087;102.383;91.837;62.1373 7 79426;303612;24516;294515;314322;24890;24330 ZFP36_10204;POLG2_9521;JUN_8938;FOXO3_8662;FOS_8657;ESR1_33192;EGR1_8533 16.843250142857325 13.1992 22.63420155074396 10.824431571428756 5.6804 14.918707052383146 34.718728571428755 31.9156 46.270497849362215 0.348134;63.7758;16.4324;13.1992;1.28141E-12;23.3972;0.750017 0.118102;40.9553;10.5224;5.6804;1.28141E-12;18.3088;0.186019 1.15962;132.567;39.929;32.7581;1.28142E-12;31.9156;4.70178 0 Exp 2,7(0.5);Exp 3,1(0.08);Exp 4,1(0.08);Hill,3(0.22);Linear,1(0.08);Poly 2,1(0.08) 2.0015472685689075 29.028621077537537 1.5504547357559204 4.21828556060791 0.6735972517308784 1.917422354221344 18.480016466812735 42.94821939033031 12.890528973571834 30.82355974071406 31.603220466688303 76.09500810474046 CONFLICT 0.5 0.5 0.0 GO:0032218 6 riboflavin transport 1 1 1 1 1 1 1 1 161 0 2385 1.0 0.063604 0.063604 100.0 312382 abcg2 ABCG2_32656 5.21654 5.21654 5.21654 5.21654 2.73368 2.73368 2.73368 2.73368 11.386 11.386 11.386 11.386 0.0 5.21654 0.0 5.21654 5.21654 2.73368 11.386 1 0 1 312382 ABCG2_32656 5.21654 5.21654 2.73368 2.73368 11.386 11.386 5.21654 2.73368 11.386 0 0 Exp 4,1(1) 1.5074360370635986 1.5074360370635986 1.5074360370635986 1.5074360370635986 0.0 1.5074360370635986 5.21654 5.21654 2.73368 2.73368 11.386 11.386 UP 1.0 0.0 0.0 GO:0070723 6 response to cholesterol 17 17 2 2 2 2 2 2 160 15 2370 0.91096 0.295 0.295 11.76 25675;25428 hmgcr;cyp7a1 HMGCR_8810;CYP7A1_8430 3.676085 3.676085 1.63089 2.892342506697643 3.617223746002741 2.891144389615597 0.824205 0.824205 0.663137 0.22778455006430948 0.8195694202832343 0.22769019313395744 14.99555 14.99555 7.6286 10.418440603324473 14.783527227044312 10.414124893263788 0.0 1.63089 0.5 3.676085 1.63089;5.72128 0.663137;0.985273 7.6286;22.3625 0 2 0 2 25675;25428 HMGCR_8810;CYP7A1_8430 3.676085 3.676085 2.892342506697643 0.824205 0.824205 0.22778455006430948 14.99555 14.99555 10.418440603324473 1.63089;5.72128 0.663137;0.985273 7.6286;22.3625 0 Exp 4,1(0.5);Hill,1(0.5) 2.9449443680706877 6.462099075317383 1.9017701148986816 4.560328960418701 1.879884987850685 3.2310495376586914 -0.33249719999999927 7.6846672 0.50851172 1.13989828 0.5563280000000006 29.434772000000002 DOWN 0.0 1.0 0.0 GO:2001236 7 regulation of extrinsic apoptotic signaling pathway 62 65 4 4 3 3 2 2 160 63 2322 0.20585 0.92695 0.43533 3.08 289388;361969 g0s2;fga G0S2_32729;FGA_8632 37.47935 37.47935 28.5803 12.585157202236308 32.787258302122346 10.693677234815686 28.160200000000003 28.160200000000003 22.529 7.963719412435362 25.19110703287557 6.7668161483185605 56.252 56.252 38.8511 24.608588777497985 47.077243320848936 20.91005311750177 46.3784;28.5803 33.7914;22.529 73.6529;38.8511 1 1 1 289388 G0S2_32729 46.3784 46.3784 33.7914 33.7914 73.6529 73.6529 46.3784 33.7914 73.6529 1 361969 FGA_8632 28.5803 28.5803 22.529 22.529 38.8511 38.8511 28.5803 22.529 38.8511 0 Linear,2(1) 1.8771222762361726 3.8271267414093018 1.541895866394043 2.285230875015259 0.5256172252894225 1.9135633707046509 20.037212 54.921488 17.123048 39.19735200000001 22.146236000000002 90.357764 CONFLICT 0.5 0.5 0.0 GO:0048731 4 system development 102 110 10 10 9 9 8 8 154 102 2283 0.73716 0.40044 0.68761 7.27 29482;81819;29540;314322;25661;29496;79431;65183 slc1a2;pax8;hsd17b7;fos;fn1;erbb3;bhlhe40;aldh3a2 SLC1A2_33059;PAX8_9432;HSD17B7_8834;FOS_8657;FN1_8655;ERBB3_8571;BHLHE40_8141;ALDH3A2_8024 36.58582425000016 50.0005 1.28141E-12 27.196471778719594 43.766661394124085 23.588306894137247 24.67855025000016 31.46365 1.28141E-12 18.62444693617681 29.147285251863718 16.200355111843464 63.48020250000015 73.9373 1.28142E-12 47.426398145999705 73.93081552724509 40.7827317925854 4.5 57.3508 13.3235;56.8931;0.977494;1.28141E-12;59.5777;60.9984;57.8085;43.1079 9.10952;45.1162;0.322682;1.28141E-12;31.0499;41.6036;38.3491;31.8774 24.6773;81.5688;5.49472;1.28142E-12;105.243;113.972;110.58;66.3058 3 5 3 81819;29496;65183 PAX8_9432;ERBB3_8571;ALDH3A2_8024 53.66646666666667 56.8931 9.371545740342576 39.532399999999996 41.6036 6.858123536361866 87.28219999999999 81.5688 24.341299478047638 56.8931;60.9984;43.1079 45.1162;41.6036;31.8774 81.5688;113.972;66.3058 5 29482;29540;314322;25661;79431 SLC1A2_33059;HSD17B7_8834;FOS_8657;FN1_8655;BHLHE40_8141 26.337438800000257 13.3235 30.006219120339207 15.766240400000257 9.10952 17.85332992308804 49.19900400000025 24.6773 54.40697694048116 13.3235;0.977494;1.28141E-12;59.5777;57.8085 9.10952;0.322682;1.28141E-12;31.0499;38.3491 24.6773;5.49472;1.28142E-12;105.243;110.58 0 Exp 2,2(0.25);Exp 4,1(0.13);Hill,1(0.13);Linear,2(0.25);Poly 2,1(0.13);Power,1(0.13) 1.6962902342700006 13.598737120628357 1.520427942276001 1.8966681957244873 0.11750363196375435 1.7142949104309082 17.739630823300597 55.432017676699715 11.772466980068913 37.58463351993141 30.615385318436452 96.34501968156385 DOWN 0.375 0.625 0.0 GO:0006144 6 purine nucleobase metabolic process 4 6 1 1 1 1 1 1 161 5 2380 0.9491 0.32612 0.32612 16.67 24856 ttr TTR_10102 46.6406 46.6406 46.6406 46.6406 28.5876 28.5876 28.5876 28.5876 63.7146 63.7146 63.7146 63.7146 0.0 46.6406 0.0 46.6406 46.6406 28.5876 63.7146 1 0 1 24856 TTR_10102 46.6406 46.6406 28.5876 28.5876 63.7146 63.7146 46.6406 28.5876 63.7146 0 0 Poly 2,1(1) 1.9248499870300293 1.9248499870300293 1.9248499870300293 1.9248499870300293 0.0 1.9248499870300293 46.6406 46.6406 28.5876 28.5876 63.7146 63.7146 UP 1.0 0.0 0.0 GO:0001661 8 conditioned taste aversion 2 2 1 1 1 1 1 1 161 1 2384 0.99598 0.12319 0.12319 50.0 314322 fos FOS_8657 1.28141E-12 1.28141E-12 1.28141E-12 1.2814100000000003E-12 1.28141E-12 1.28141E-12 1.28141E-12 1.2814100000000003E-12 1.28142E-12 1.28142E-12 1.28142E-12 1.28142E-12 0.0 1.28141E-12 0.0 1.28141E-12 1.28141E-12 1.28141E-12 1.28142E-12 0 1 0 1 314322 FOS_8657 1.28141E-12 1.28141E-12 1.28141E-12 1.28141E-12 1.28142E-12 1.28142E-12 1.28141E-12 1.28141E-12 1.28142E-12 0 Hill,1(1) 1.8966681957244873 1.8966681957244873 1.8966681957244873 1.8966681957244873 0.0 1.8966681957244873 1.28141E-12 1.28141E-12 1.28141E-12 1.28141E-12 1.28142E-12 1.28142E-12 DOWN 0.0 1.0 0.0 GO:0007253 10 cytoplasmic sequestering of NF-kappaB 3 3 2 2 2 2 2 2 160 1 2384 0.99975 0.011561 0.011561 66.67 81525;25493 nfkbib;nfkbia NFKBIB_9308;NFKBIA_9307 15.5386755 15.5386755 0.520151 21.23940103473261 26.7781099264949 14.087667793472523 12.202051 12.202051 0.160202 17.02974617184889 21.213826571511913 11.295488337163835 22.073045 22.073045 2.88499 27.136007616560878 36.43283686533787 17.998768417155745 0.0 0.520151 0.0 0.520151 30.5572;0.520151 24.2439;0.160202 41.2611;2.88499 1 1 1 81525 NFKBIB_9308 30.5572 30.5572 24.2439 24.2439 41.2611 41.2611 30.5572 24.2439 41.2611 1 25493 NFKBIA_9307 0.520151 0.520151 0.160202 0.160202 2.88499 2.88499 0.520151 0.160202 2.88499 0 Exp 2,1(0.5);Exp 4,1(0.5) 1.6846181942773581 3.3848170042037964 1.5302108526229858 1.8546061515808105 0.22938211567811523 1.6924085021018982 -13.897632520000002 44.97498352 -11.399973039999995 35.80407504 -15.535542799999995 59.681632799999996 CONFLICT 0.5 0.5 0.0 GO:0010038 5 response to metal ion 201 215 25 25 21 23 19 19 143 196 2189 0.95023 0.083609 0.14188 8.84 24825;24648;83516;24651;25513;25591;24314;24567;24516;24464;314322;25661;361969;497840;25698;65054;155423;24158;312382 tf;serpina1;ppargc1a;pklr;pik3r1;parp1;nqo1;mt1;jun;hp;fos;fn1;fga;cps1;ass1;aqp9;anxa7;acadm;abcg2 TF_10003;SERPINA1_9807;PPARGC1A_33189;PKLR_9489;PIK3R1_32562;PARP1_9425;NQO1_33055;MT1A_9255;JUN_8938;HP_8823;FOS_8657;FN1_8655;FGA_8632;CPS1_32421;ASS1_33159;AQP9_32709;ANXA7_8051;ACADM_7957;ABCG2_32656 34.20937578947375 26.9741 1.28141E-12 27.612773669272446 36.48789300916761 25.599938131682183 21.901074736842173 21.799 1.28141E-12 15.019570377779376 22.810764754989812 12.653806530775906 56.46617894736848 38.8511 1.28142E-12 49.26142180477958 58.451974705851576 42.001151015160545 9.5 27.35285 45.1539;15.797;42.4094;23.0963;18.7324;26.9741;87.2765;12.9315;16.4324;64.9285;1.28141E-12;59.5777;28.5803;31.9826;26.8037;27.7316;104.64;11.7137;5.21654 28.132;13.013;26.2988;17.4625;11.6701;21.799;60.6992;8.91033;10.5224;41.6103;1.28141E-12;31.0499;22.529;24.4836;20.9825;21.9372;43.9254;8.36151;2.73368 61.5341;19.9134;81.7305;32.9443;41.5978;35.2797;197.117;23.4636;39.929;136.455;1.28142E-12;105.243;38.8511;45.5891;36.7081;37.4625;108.689;18.9642;11.386 6 13 6 24825;25591;24314;155423;24158;312382 TF_10003;PARP1_9425;NQO1_33055;ANXA7_8051;ACADM_7957;ABCG2_32656 46.829123333333335 36.064 40.840705460411264 27.608465 24.9655 21.837872097277018 72.16166666666666 48.4069 70.63279431804088 45.1539;26.9741;87.2765;104.64;11.7137;5.21654 28.132;21.799;60.6992;43.9254;8.36151;2.73368 61.5341;35.2797;197.117;108.689;18.9642;11.386 13 24648;83516;24651;25513;24567;24516;24464;314322;25661;361969;497840;25698;65054 SERPINA1_9807;PPARGC1A_33189;PKLR_9489;PIK3R1_32562;MT1A_9255;JUN_8938;HP_8823;FOS_8657;FN1_8655;FGA_8632;CPS1_32421;ASS1_33159;AQP9_32709 28.38487692307702 26.8037 18.229985240127064 19.266894615384714 20.9825 10.764370332081954 49.222107692307794 38.8511 37.165322821627136 15.797;42.4094;23.0963;18.7324;12.9315;16.4324;64.9285;1.28141E-12;59.5777;28.5803;31.9826;26.8037;27.7316 13.013;26.2988;17.4625;11.6701;8.91033;10.5224;41.6103;1.28141E-12;31.0499;22.529;24.4836;20.9825;21.9372 19.9134;81.7305;32.9443;41.5978;23.4636;39.929;136.455;1.28142E-12;105.243;38.8511;45.5891;36.7081;37.4625 0 Exp 2,8(0.43);Exp 3,1(0.06);Exp 4,1(0.06);Hill,1(0.06);Linear,2(0.11);Poly 2,5(0.27);Power,1(0.06) 1.7941781142291542 34.42620527744293 1.5074360370635986 2.6967689990997314 0.27976628615434235 1.7792335748672485 21.793158507819548 46.62559307112796 15.147452245990113 28.654697227694232 34.31554228706092 78.61681560767606 DOWN 0.3157894736842105 0.6842105263157895 0.0 GO:0007423 5 sensory organ development 31 32 3 3 3 3 3 3 159 29 2356 0.85787 0.33306 0.45354 9.38 308843;81819;29496 tsku;pax8;erbb3 TSKU_10094;PAX8_9432;ERBB3_8571 39.75855333333333 56.8931 1.38416 33.29653014652628 51.555230286792906 23.22602983294099 29.086789333333332 41.6036 0.540568 24.78406048247021 38.27481582414905 17.494381615383105 66.54984 81.5688 4.10872 56.45052650508053 84.12845752907506 41.18638993947393 0.5 29.13863 1.38416;56.8931;60.9984 0.540568;45.1162;41.6036 4.10872;81.5688;113.972 2 1 2 81819;29496 PAX8_9432;ERBB3_8571 58.94575 58.94575 2.902885468805186 43.359899999999996 43.359899999999996 2.4837832795959702 97.7704 97.7704 22.912522452143893 56.8931;60.9984 45.1162;41.6036 81.5688;113.972 1 308843 TSKU_10094 1.38416 1.38416 0.540568 0.540568 4.10872 4.10872 1.38416 0.540568 4.10872 0 Exp 2,1(0.34);Hill,1(0.34);Linear,1(0.34) 2.0283935007065 6.327905178070068 1.6013026237487793 2.9744045734405518 0.75299040807835 1.7521979808807373 2.0799824727055523 77.43712419396111 1.0409847106476988 57.132593956018965 2.6700557197354584 130.42962428026453 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0032731 8 positive regulation of interleukin-1 beta production 22 23 4 4 3 4 3 3 159 20 2365 0.94591 0.17665 0.17665 13.04 24539;24471;24330 lpl;hspb1;egr1 LPL_32544;HSPB1_8847;EGR1_8533 54.68507233333333 74.2041 0.750017 47.299289609964504 57.85507675778672 44.922291165392195 36.793573 49.8682 0.186019 32.13142958412662 38.92982817291262 30.509444459458166 88.75492666666668 106.138 4.70178 76.85050872099764 96.89727282039692 75.81584811678266 0.5 37.4770585 1.5 81.6526 74.2041;89.1011;0.750017 49.8682;60.3265;0.186019 155.425;106.138;4.70178 1 2 1 24539 LPL_32544 74.2041 74.2041 49.8682 49.8682 155.425 155.425 74.2041 49.8682 155.425 2 24471;24330 HSPB1_8847;EGR1_8533 44.9255585 44.9255585 62.4736499144755 30.256259500000002 30.256259500000002 42.52574193892072 55.41989 55.41989 71.7262390199305 89.1011;0.750017 60.3265;0.186019 106.138;4.70178 0 Exp 2,1(0.34);Hill,1(0.34);Poly 2,1(0.34) 2.235040819974675 7.475002288818359 1.559399127960205 4.21828556060791 1.4968844324054515 1.6973176002502441 1.1608874593028133 108.20925720736386 0.4334375411077147 73.15370845889231 1.790389347708441 175.71946398562488 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0052548 7 regulation of endopeptidase activity 137 148 19 19 17 17 15 15 147 133 2252 0.97696 0.04531 0.057011 10.14 79224;24794;24648;252922;29441;299282;288001;54404;50693;306251;63868;83928;24360;25377;25373 serpind1;serpina3c;serpina1;pzp;por;loc299282;kng1;itih4;itih3;itih1;hspd1;fetub;fabp1;ambp;ahsg SERPIND1_9812;SERPINA3C_32925;SERPINA1_9807;PZP_9633;POR_9531;LOC299282_9119;KNG1L1_34113;ITIH4_32725;ITIH3_32422;ITIH1_33132;HSPD1_8849;FETUB_33027;FABP1_33091;AMBP_33085;AHSG_8003 34.046153333333336 29.766 12.402 21.68478787428335 40.73686367683313 24.84875481880656 22.81754066666667 22.307 8.48981 9.758717225424995 25.518161484961613 10.895840585956135 54.46077333333334 46.9257 15.4235 30.915104137609443 66.64976395999155 30.732885863261348 6.5 29.0135 13.5 77.6452 28.261;29.766;15.797;34.1871;12.4414;45.2017;24.3655;57.1163;27.1247;98.1741;42.2579;32.5155;33.8478;17.2343;12.402 22.307;23.347;13.013;26.3085;8.48981;30.7472;19.538;39.6402;21.5108;42.9071;23.9469;19.6094;26.4736;14.1233;10.3013 38.3264;40.8256;19.9134;48.5666;79.2355;78.6415;32.1467;101.869;36.4819;104.278;102.383;49.9875;46.9257;21.9073;15.4235 2 13 2 63868;24360 HSPD1_8849;FABP1_33091 38.05285 38.05285 5.946838740456993 25.210250000000002 25.210250000000002 1.786646704023996 74.65435 74.65435 39.214232896296714 42.2579;33.8478 23.9469;26.4736 102.383;46.9257 13 79224;24794;24648;252922;29441;299282;288001;54404;50693;306251;83928;25377;25373 SERPIND1_9812;SERPINA3C_32925;SERPINA1_9807;PZP_9633;POR_9531;LOC299282_9119;KNG1L1_34113;ITIH4_32725;ITIH3_32422;ITIH1_33132;FETUB_33027;AMBP_33085;AHSG_8003 33.42973846153846 28.261 23.29307595608397 22.449431538461543 21.5108 10.475575114503133 51.35406923076924 40.8256 30.14081288990019 28.261;29.766;15.797;34.1871;12.4414;45.2017;24.3655;57.1163;27.1247;98.1741;32.5155;17.2343;12.402 22.307;23.347;13.013;26.3085;8.48981;30.7472;19.538;39.6402;21.5108;42.9071;19.6094;14.1233;10.3013 38.3264;40.8256;19.9134;48.5666;79.2355;78.6415;32.1467;101.869;36.4819;104.278;49.9875;21.9073;15.4235 0 Exp 2,5(0.34);Exp 3,2(0.14);Linear,6(0.4);Poly 2,2(0.14) 1.935463152825372 29.91658890247345 1.5197933912277222 3.431420087814331 0.5512017779456058 1.7033517360687256 23.072136552389708 45.02017011427695 17.878948358862644 27.75613297447068 38.81557202642602 70.10597464024065 DOWN 0.13333333333333333 0.8666666666666667 0.0 GO:0016070 6 RNA metabolic process 159 180 14 13 11 13 10 10 152 170 2215 0.39609 0.72307 0.75252 5.56 79426;297784;81819;24516;364070;294515;314322;308441;24890;24330 zfp36;rrs1;pax8;jun;iars2;foxo3;fos;exosc5;esr1;egr1 ZFP36_10204;RRS1_9755;PAX8_9432;JUN_8938;IARS2_8858;FOXO3_8662;FOS_8657;EXOSC5_32543;ESR1_33192;EGR1_8533 23.80733510000013 19.9148 1.28141E-12 22.554134899454844 28.231327226412894 26.48351512396774 17.457662100000128 14.415600000000001 1.28141E-12 17.39588332956634 21.098392463484345 20.6290048065396 39.18209000000013 32.7334 1.28142E-12 34.88761157141552 45.96457395402518 39.78152392531452 8.0 56.8931 0.348134;60.39;56.8931;16.4324;24.7304;13.1992;1.28141E-12;41.9329;23.3972;0.750017 0.118102;43.109;45.1162;10.5224;19.8021;5.6804;1.28141E-12;31.7336;18.3088;0.186019 1.15962;104.942;81.5688;39.929;32.7087;32.7581;1.28142E-12;62.1373;31.9156;4.70178 4 6 4 297784;81819;364070;308441 RRS1_9755;PAX8_9432;IARS2_8858;EXOSC5_32543 45.986599999999996 49.413 16.27542314800654 34.940225 37.4213 11.686525354833519 70.3392 71.85305 30.587488607054116 60.39;56.8931;24.7304;41.9329 43.109;45.1162;19.8021;31.7336 104.942;81.5688;32.7087;62.1373 6 79426;24516;294515;314322;24890;24330 ZFP36_10204;JUN_8938;FOXO3_8662;FOS_8657;ESR1_33192;EGR1_8533 9.021158500000213 6.9746084999999995 10.040592979794454 5.80262016666688 2.9332095 7.432713498031658 18.410683333333548 18.308690000000002 18.307132866077563 0.348134;16.4324;13.1992;1.28141E-12;23.3972;0.750017 0.118102;10.5224;5.6804;1.28141E-12;18.3088;0.186019 1.15962;39.929;32.7581;1.28142E-12;31.9156;4.70178 0 Exp 2,4(0.4);Exp 4,1(0.1);Hill,3(0.3);Linear,1(0.1);Poly 2,1(0.1) 2.100114396366199 21.846073389053345 1.5979743003845215 4.21828556060791 0.7562798214980676 1.9583411812782288 9.828137460354 37.78653273964626 6.675581906531427 28.239742293468822 17.558524320971973 60.80565567902828 DOWN 0.4 0.6 0.0 GO:0070989 4 oxidative demethylation 3 4 1 1 1 1 1 1 161 3 2382 0.97784 0.23128 0.23128 25.0 266682 cyp3a2 CYP3A2_32374 12.8505 12.8505 12.8505 12.8505 7.33176 7.33176 7.33176 7.33176 24.0283 24.0283 24.0283 24.0283 0.0 12.8505 0.0 12.8505 12.8505 7.33176 24.0283 1 0 1 266682 CYP3A2_32374 12.8505 12.8505 7.33176 7.33176 24.0283 24.0283 12.8505 7.33176 24.0283 0 0 Hill,1(1) 3.1564550399780273 3.1564550399780273 3.1564550399780273 3.1564550399780273 0.0 3.1564550399780273 12.8505 12.8505 7.33176 7.33176 24.0283 24.0283 UP 1.0 0.0 0.0 GO:0006090 8 pyruvate metabolic process 20 25 5 5 4 4 3 3 159 22 2363 0.92992 0.20982 0.20982 12.0 24651;100359982;24552 pklr;mpc2;me1 PKLR_9489;MPC2_33219;ME1_9215 50.245666666666665 46.8463 23.0963 28.998869912521304 40.23690252208048 22.310714558971075 37.722633333333334 35.8494 17.4625 21.258738506866624 30.478599538763493 16.589053983504797 65.3778 69.127 32.9443 30.730908621288776 56.06911815505397 26.6084562468679 0.5 34.9713 1.5 63.82035 23.0963;46.8463;80.7944 17.4625;35.8494;59.856 32.9443;69.127;94.0621 1 2 1 100359982 MPC2_33219 46.8463 46.8463 35.8494 35.8494 69.127 69.127 46.8463 35.8494 69.127 2 24651;24552 PKLR_9489;ME1_9215 51.94535 51.94535 40.79871777157954 38.65925 38.65925 29.976731328231903 63.5032 63.5032 43.21681083120318 23.0963;80.7944 17.4625;59.856 32.9443;94.0621 0 Exp 2,2(0.67);Poly 2,1(0.34) 2.3096784981687875 6.995833992958069 1.9223796129226685 2.6967689990997314 0.3891285509294171 2.376685380935669 17.430356180296002 83.06097715303733 13.666106070173576 61.77916059649309 30.602503204711986 100.15309679528801 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:1904705 7 regulation of vascular smooth muscle cell proliferation 30 31 3 3 3 2 2 2 160 29 2356 0.68484 0.59663 1.0 6.45 24516;114851 jun;cdkn1a JUN_8938;CDKN1A_8271 11.341035000000002 11.341035000000002 6.24967 7.200277433991694 9.136656064685733 6.490410013669051 6.481325 6.481325 2.44025 5.714943071566854 4.731684067553572 5.151513129777114 29.4948 29.4948 19.0606 14.756187152513343 24.977164614036482 13.301390916704191 0.5 11.341035000000002 16.4324;6.24967 10.5224;2.44025 39.929;19.0606 0 2 0 2 24516;114851 JUN_8938;CDKN1A_8271 11.341035000000002 11.341035000000002 7.200277433991694 6.481325 6.481325 5.714943071566854 29.4948 29.4948 14.756187152513343 16.4324;6.24967 10.5224;2.44025 39.929;19.0606 0 Exp 4,1(0.5);Poly 2,1(0.5) 1.7353651457298567 3.500610113143921 1.522104263305664 1.9785058498382568 0.3227246567814952 1.7503050565719604 1.3619596000000005 21.320110400000004 -1.439181999999997 14.401831999999997 9.043768000000004 49.945831999999996 DOWN 0.0 1.0 0.0 GO:0034660 7 ncRNA metabolic process 43 51 4 3 2 4 2 2 160 49 2336 0.35991 0.84641 0.76928 3.92 364070;308441 iars2;exosc5 IARS2_8858;EXOSC5_32543 33.331649999999996 33.331649999999996 24.7304 12.164004403361579 33.184773177842565 12.162230779064577 25.76785 25.76785 19.8021 8.436844559727287 25.665977551020408 8.435614389792683 47.423 47.423 32.7087 20.809162620826424 47.17173540191587 20.806128452537738 24.7304;41.9329 19.8021;31.7336 32.7087;62.1373 2 0 2 364070;308441 IARS2_8858;EXOSC5_32543 33.331649999999996 33.331649999999996 12.164004403361579 25.76785 25.76785 8.436844559727287 47.423 47.423 20.809162620826424 24.7304;41.9329 19.8021;31.7336 32.7087;62.1373 0 0 Exp 2,1(0.5);Linear,1(0.5) 1.6755936074843947 3.3549574613571167 1.5979743003845215 1.7569831609725952 0.11243624359057329 1.6774787306785583 16.473200000000002 50.19009999999999 14.074980000000002 37.460719999999995 18.582972000000005 76.26302799999999 UP 1.0 0.0 0.0 GO:0045596 6 negative regulation of cell differentiation 184 195 10 10 7 6 5 5 157 190 2195 0.011001 0.99636 0.02105 2.56 79426;246273;25513;25493;294515 zfp36;trib3;pik3r1;nfkbia;foxo3 ZFP36_10204;TRIB3_10079;PIK3R1_32562;NFKBIA_9307;FOXO3_8662 28.172776999999996 13.1992 0.348134 45.37293995677961 41.146307202788336 51.658803435706076 20.3024808 5.6804 0.118102 35.860850891750204 30.5096272884981 41.0199721278874 44.365702 32.7581 1.15962 58.18752353496942 61.402885819074775 64.87932368458655 0.348134;108.064;18.7324;0.520151;13.1992 0.118102;83.8836;11.6701;0.160202;5.6804 1.15962;143.428;41.5978;2.88499;32.7581 0 5 0 5 79426;246273;25513;25493;294515 ZFP36_10204;TRIB3_10079;PIK3R1_32562;NFKBIA_9307;FOXO3_8662 28.172776999999996 13.1992 45.37293995677961 20.3024808 5.6804 35.860850891750204 44.365702 32.7581 58.18752353496942 0.348134;108.064;18.7324;0.520151;13.1992 0.118102;83.8836;11.6701;0.160202;5.6804 1.15962;143.428;41.5978;2.88499;32.7581 0 Exp 4,2(0.4);Hill,1(0.2);Poly 2,2(0.4) 1.863183583576276 9.33184027671814 1.6735800504684448 1.9883413314819336 0.11984932774303732 1.87713623046875 -11.598358408291226 67.94391240829123 -11.130940927375459 51.73590252737546 -6.6379111620917115 95.36931516209171 DOWN 0.0 1.0 0.0 GO:0072376 4 protein activation cascade 8 8 2 2 2 2 2 2 160 6 2379 0.98885 0.087405 0.087405 25.0 361969;304929 fga;f5 FGA_8632;F5_33079 19.5946 19.5946 10.6089 12.707698807415921 25.55791133272892 9.505968907896428 12.560145 12.560145 2.59129 14.098089942330839 19.175921844968265 10.546048240796809 38.17945 38.17945 37.5078 0.9498565391680657 38.625186899365374 0.7105383016331773 0.0 10.6089 0.0 10.6089 28.5803;10.6089 22.529;2.59129 38.8511;37.5078 0 2 0 2 361969;304929 FGA_8632;F5_33079 19.5946 19.5946 12.707698807415921 12.560145 12.560145 14.098089942330839 38.17945 38.17945 0.9498565391680657 28.5803;10.6089 22.529;2.59129 38.8511;37.5078 0 Hill,1(0.5);Linear,1(0.5) 1.6210317177732612 3.2461249828338623 1.541895866394043 1.7042291164398193 0.11478694191941989 1.6230624914169312 1.9826279999999983 37.206572 -6.978810799999996 32.099100799999995 36.863016 39.495884000000004 DOWN 0.0 1.0 0.0 GO:0046320 8 regulation of fatty acid oxidation 13 13 4 4 3 4 3 3 159 10 2375 0.99283 0.045051 0.045051 23.08 83516;24360;25287 ppargc1a;fabp1;acadl PPARGC1A_33189;FABP1_33091;ACADL_32776 36.58166666666667 33.8478 33.4878 5.050173942878888 37.24572736077482 5.220265656292165 26.458766666666666 26.4736 26.2988 0.1530899191110576 26.428023317925014 0.14274647954028585 57.993 46.9257 45.3228 20.572894832521765 60.71204131631082 21.250762659088135 0.0 33.4878 0.5 33.6678 42.4094;33.8478;33.4878 26.2988;26.4736;26.6039 81.7305;46.9257;45.3228 2 1 2 24360;25287 FABP1_33091;ACADL_32776 33.6678 33.6678 0.25455844122736293 26.53875 26.53875 0.09213601359002013 46.12425 46.12425 1.1334214595636942 33.8478;33.4878 26.4736;26.6039 46.9257;45.3228 1 83516 PPARGC1A_33189 42.4094 42.4094 26.2988 26.2988 81.7305 81.7305 42.4094 26.2988 81.7305 0 Exp 2,3(1) 1.8391201412087588 5.520191788673401 1.7576230764389038 1.8872262239456177 0.07164270019002918 1.8753424882888794 30.86685686733052 42.29647646600281 26.285529114889414 26.632004218443925 34.712577915650066 81.27342208434993 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0052547 6 regulation of peptidase activity 146 157 20 20 18 18 16 16 146 141 2244 0.98091 0.037621 0.060359 10.19 79224;24794;24648;252922;29441;299282;288001;54404;50693;306251;63868;25661;83928;24360;25377;25373 serpind1;serpina3c;serpina1;pzp;por;loc299282;kng1;itih4;itih3;itih1;hspd1;fn1;fetub;fabp1;ambp;ahsg SERPIND1_9812;SERPINA3C_32925;SERPINA1_9807;PZP_9633;POR_9531;LOC299282_9119;KNG1L1_34113;ITIH4_32725;ITIH3_32422;ITIH1_33132;HSPD1_8849;FN1_8655;FETUB_33027;FABP1_33091;AMBP_33085;AHSG_8003 35.641875 31.14075 12.402 21.90028764671064 43.049649796089874 24.08384838576573 23.332063125 22.826999999999998 8.48981 9.649842391916192 26.19720395598013 10.35365028903999 57.634662500000005 47.74615 15.4235 32.4531135433849 71.38723415927237 31.55897375355071 6.5 29.0135 14.5 78.8759 28.261;29.766;15.797;34.1871;12.4414;45.2017;24.3655;57.1163;27.1247;98.1741;42.2579;59.5777;32.5155;33.8478;17.2343;12.402 22.307;23.347;13.013;26.3085;8.48981;30.7472;19.538;39.6402;21.5108;42.9071;23.9469;31.0499;19.6094;26.4736;14.1233;10.3013 38.3264;40.8256;19.9134;48.5666;79.2355;78.6415;32.1467;101.869;36.4819;104.278;102.383;105.243;49.9875;46.9257;21.9073;15.4235 2 14 2 63868;24360 HSPD1_8849;FABP1_33091 38.05285 38.05285 5.946838740456993 25.210250000000002 25.210250000000002 1.786646704023996 74.65435 74.65435 39.214232896296714 42.2579;33.8478 23.9469;26.4736 102.383;46.9257 14 79224;24794;24648;252922;29441;299282;288001;54404;50693;306251;25661;83928;25377;25373 SERPIND1_9812;SERPINA3C_32925;SERPINA1_9807;PZP_9633;POR_9531;LOC299282_9119;KNG1L1_34113;ITIH4_32725;ITIH3_32422;ITIH1_33132;FN1_8655;FETUB_33027;AMBP_33085;AHSG_8003 35.297450000000005 29.0135 23.445005525361474 23.06375071428572 21.9089 10.323746758793503 55.20327857142858 44.6961 32.34217335324025 28.261;29.766;15.797;34.1871;12.4414;45.2017;24.3655;57.1163;27.1247;98.1741;59.5777;32.5155;17.2343;12.402 22.307;23.347;13.013;26.3085;8.48981;30.7472;19.538;39.6402;21.5108;42.9071;31.0499;19.6094;14.1233;10.3013 38.3264;40.8256;19.9134;48.5666;79.2355;78.6415;32.1467;101.869;36.4819;104.278;105.243;49.9875;21.9073;15.4235 0 Exp 2,5(0.32);Exp 3,2(0.13);Linear,6(0.38);Poly 2,2(0.13);Power,1(0.07) 1.9253088683376953 31.6958224773407 1.5197933912277222 3.431420087814331 0.5352224767448553 1.741292655467987 24.910734053111785 46.373015946888216 18.603640352961058 28.060485897038937 41.732636863741384 73.5366881362586 DOWN 0.125 0.875 0.0 GO:0019538 4 protein metabolic process 588 639 39 39 30 35 27 27 135 612 1773 0.0054564 0.99702 0.011159 4.23 79426;312688;246273;24825;293615;29676;192280;29441;85253;25513;25591;364070;65164;24464;24957;25661;361969;304929;29496;171142;116663;25423;497840;113936;291394;29184;25377 zfp36;usp18;trib3;tf;sirt3;psmb3;ppp1r3b;por;plg;pik3r1;parp1;iars2;htra1;hp;glul;fn1;fga;f5;erbb3;ehhadh;dusp6;ctsc;cps1;cpb2;cndp2;cd36;ambp ZFP36_10204;USP18_10138;TRIB3_10079;TF_10003;SIRT3_9828;PSMB3_9589;PPP1R3B_9545;POR_9531;PLG_9501;PIK3R1_32562;PARP1_9425;IARS2_8858;HTRA1_8856;HP_8823;GLUL_32832;FN1_8655;FGA_8632;F5_33079;ERBB3_8571;EHHADH_8534;DUSP6_8506;CTSC_32456;CPS1_32421;CPB2_8369;CNDP2_8341;CD36_8243;AMBP_33085 38.766603851851855 31.9826 0.348134 28.080440521842608 41.39319969086053 24.787184504611314 27.176723777777777 24.4836 0.118102 19.56901144080093 28.787518106966424 16.764272511787482 65.01776629629629 46.311 1.15962 45.74379154287524 70.52806293159334 43.97443258451072 0.348134;108.883;108.064;45.1539;2.38018;23.7888;36.1411;12.4414;70.7857;18.7324;26.9741;24.7304;33.1323;64.9285;26.4669;59.5777;28.5803;10.6089;60.9984;8.62809;62.3934;56.2386;31.9826;25.8316;33.544;48.1296;17.2343 0.118102;73.1414;83.8836;28.132;0.56209;19.2724;27.0588;8.48981;46.2356;11.6701;21.799;19.8021;25.6145;41.6103;21.0456;31.0499;22.529;2.59129;41.6036;7.31865;39.0875;38.2681;24.4836;20.4374;26.3005;37.5433;14.1233 1.15962;138.144;143.428;61.5341;8.82917;30.901;53.6244;79.2355;150.579;41.5978;35.2797;32.7087;46.6629;136.455;35.4303;105.243;38.8511;37.5078;113.972;10.3909;133.304;102.888;45.5891;34.8042;46.311;69.1421;21.9073 10 17 10 312688;24825;293615;29676;25591;364070;29496;171142;291394;29184 USP18_10138;TF_10003;SIRT3_9828;PSMB3_9589;PARP1_9425;IARS2_8858;ERBB3_8571;EHHADH_8534;CNDP2_8341;CD36_8243 38.321047 30.25905 30.472264313376314 27.547504000000004 24.04975 20.21309479278893 54.721267 40.79535 42.552331454399926 108.883;45.1539;2.38018;23.7888;26.9741;24.7304;60.9984;8.62809;33.544;48.1296 73.1414;28.132;0.56209;19.2724;21.799;19.8021;41.6036;7.31865;26.3005;37.5433 138.144;61.5341;8.82917;30.901;35.2797;32.7087;113.972;10.3909;46.311;69.1421 17 79426;246273;192280;29441;85253;25513;65164;24464;24957;25661;361969;304929;116663;25423;497840;113936;25377 ZFP36_10204;TRIB3_10079;PPP1R3B_9545;POR_9531;PLG_9501;PIK3R1_32562;HTRA1_8856;HP_8823;GLUL_32832;FN1_8655;FGA_8632;F5_33079;DUSP6_8506;CTSC_32456;CPS1_32421;CPB2_8369;AMBP_33085 39.02869611764705 31.9826 27.546672470134787 26.95861776470588 24.4836 19.807345771854504 71.07453058823529 46.6629 47.71316262477951 0.348134;108.064;36.1411;12.4414;70.7857;18.7324;33.1323;64.9285;26.4669;59.5777;28.5803;10.6089;62.3934;56.2386;31.9826;25.8316;17.2343 0.118102;83.8836;27.0588;8.48981;46.2356;11.6701;25.6145;41.6103;21.0456;31.0499;22.529;2.59129;39.0875;38.2681;24.4836;20.4374;14.1233 1.15962;143.428;53.6244;79.2355;150.579;41.5978;46.6629;136.455;35.4303;105.243;38.8511;37.5078;133.304;102.888;45.5891;34.8042;21.9073 0 Exp 2,12(0.45);Hill,3(0.12);Linear,6(0.23);Poly 2,4(0.15);Power,2(0.08) 1.9440269348197157 78.49821603298187 1.5209722518920898 32.73371124267578 5.966459402177571 1.7042291164398193 28.174600587609106 49.3586071160946 19.795250082671878 34.55819747288369 47.76310859375466 82.27242399883798 DOWN 0.37037037037037035 0.6296296296296297 0.0 GO:0032103 6 positive regulation of response to external stimulus 125 131 8 8 8 8 8 8 154 123 2262 0.5438 0.60284 1.0 6.11 85253;25493;24539;63868;24471;25661;25423;113936 plg;nfkbia;lpl;hspd1;hspb1;fn1;ctsc;cpb2 PLG_9501;NFKBIA_9307;LPL_32544;HSPD1_8849;HSPB1_8847;FN1_8655;CTSC_32456;CPB2_8369 52.314606375 57.90815 0.520151 28.602897396750564 63.0281168397509 19.229683292831936 33.78660025 34.659 0.160202 19.091099646149267 40.02018076306042 14.31098535715073 95.04314875 104.0655 2.88499 52.36493333523209 116.30615450751888 34.53926360569986 5.5 72.4949 70.7857;0.520151;74.2041;42.2579;89.1011;59.5777;56.2386;25.8316 46.2356;0.160202;49.8682;23.9469;60.3265;31.0499;38.2681;20.4374 150.579;2.88499;155.425;102.383;106.138;105.243;102.888;34.8042 2 6 2 24539;63868 LPL_32544;HSPD1_8849 58.230999999999995 58.230999999999995 22.589374653141707 36.90755 36.90755 18.32912700717086 128.904 128.904 37.506357887696986 74.2041;42.2579 49.8682;23.9469 155.425;102.383 6 85253;25493;24471;25661;25423;113936 PLG_9501;NFKBIA_9307;HSPB1_8847;FN1_8655;CTSC_32456;CPB2_8369 50.34247516666667 57.90815 32.01017679780635 32.74628366666667 34.659 20.925388870001928 83.75619833333333 104.0655 54.27778703562644 70.7857;0.520151;89.1011;59.5777;56.2386;25.8316 46.2356;0.160202;60.3265;31.0499;38.2681;20.4374 150.579;2.88499;106.138;105.243;102.888;34.8042 0 Exp 2,3(0.38);Exp 3,1(0.13);Exp 4,1(0.13);Linear,1(0.13);Poly 2,1(0.13);Power,1(0.13) 1.7120031644202545 13.804602861404419 1.5254690647125244 2.2518506050109863 0.24332115296152995 1.6354793906211853 32.49380971839115 72.13540303160886 20.557143150301766 47.01605734969823 58.75610128143039 131.3301962185696 DOWN 0.25 0.75 0.0 GO:0048015 7 phosphatidylinositol-mediated signaling 19 20 3 3 3 3 3 3 159 17 2368 0.96571 0.13018 0.13018 15.0 25513;25685;29496 pik3r1;igfbp1;erbb3 PIK3R1_32562;IGFBP1_32306;ERBB3_8571 42.9189 49.0259 18.7324 21.7847486960488 46.729212569624956 23.0358996845551 28.653999999999996 32.6883 11.6701 15.369134260913992 31.442931656145568 16.30715452365341 81.57736666666666 89.1623 41.5978 36.77845315756676 88.99497892684737 39.403164257155 0.0 18.7324 1.0 49.0259 18.7324;49.0259;60.9984 11.6701;32.6883;41.6036 41.5978;89.1623;113.972 1 2 1 29496 ERBB3_8571 60.9984 60.9984 41.6036 41.6036 113.972 113.972 60.9984 41.6036 113.972 2 25513;25685 PIK3R1_32562;IGFBP1_32306 33.879149999999996 33.879149999999996 21.420739275874688 22.179199999999998 22.179199999999998 14.862111748335096 65.38005 65.38005 33.633180493747545 18.7324;49.0259 11.6701;32.6883 41.5978;89.1623 0 Exp 2,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 2.1968459066022614 7.2310885190963745 1.6013026237487793 3.9562058448791504 1.339226998720563 1.6735800504684448 18.267136173171426 67.57066382682856 11.262187346609629 46.04581265339037 39.958628998104196 123.19610433522914 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0032897 6 negative regulation of viral transcription 7 7 3 3 3 2 2 2 160 5 2380 0.99269 0.068343 0.068343 28.57 79426;24516 zfp36;jun ZFP36_10204;JUN_8938 8.390267000000001 8.390267000000001 0.348134 11.373293559008225 10.116718077474404 11.108129443500063 5.320251 5.320251 0.118102 7.356949669285633 6.437026331399317 7.1854251199743135 20.54431 20.54431 1.15962 27.41409150039811 24.705733211604098 26.774942138126935 0.0 0.348134 0.0 0.348134 0.348134;16.4324 0.118102;10.5224 1.15962;39.929 0 2 0 2 79426;24516 ZFP36_10204;JUN_8938 8.390267000000001 8.390267000000001 11.373293559008225 5.320251 5.320251 7.356949669285633 20.54431 20.54431 27.41409150039811 0.348134;16.4324 0.118102;10.5224 1.15962;39.929 0 Hill,1(0.5);Poly 2,1(0.5) 1.9582373626381642 3.9166823625564575 1.9381765127182007 1.9785058498382568 0.028517147758350056 1.9583411812782288 -7.372313679999998 24.152847679999997 -4.875961039999997 15.516463039999998 -17.4496824 58.538302400000006 DOWN 0.0 1.0 0.0 GO:2001235 7 positive regulation of apoptotic signaling pathway 58 59 4 4 4 3 3 3 159 56 2329 0.47638 0.73619 1.0 5.08 289388;25423;246142 g0s2;ctsc;bmf G0S2_32729;CTSC_32456;BMF_8152 65.83123333333333 56.2386 46.3784 25.632698578638458 73.2129650484472 25.550279650453163 48.3979 38.2681 33.7914 21.538886089814405 54.20923215403727 22.131649922277482 95.46296666666667 102.888 73.6529 19.205979693921666 102.07069197515527 14.644283160505658 1.5 75.55765 46.3784;56.2386;94.8767 33.7914;38.2681;73.1342 73.6529;102.888;109.848 2 1 2 289388;246142 G0S2_32729;BMF_8152 70.62755 70.62755 34.293476806019534 53.4628 53.4628 27.819560670866124 91.75045 91.75045 25.59380065572519 46.3784;94.8767 33.7914;73.1342 73.6529;109.848 1 25423 CTSC_32456 56.2386 56.2386 38.2681 38.2681 102.888 102.888 56.2386 38.2681 102.888 0 Exp 2,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 1.8289218994391843 5.560049772262573 1.5736411809921265 2.285230875015259 0.3794169985483118 1.701177716255188 36.82510430144378 94.83736236522287 24.024355903281904 72.7714440967181 73.72935467584774 117.1965786574856 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0046852 7 positive regulation of bone remodeling 11 11 3 3 2 2 2 2 160 9 2376 0.97146 0.15174 0.15174 18.18 24825;25373 tf;ahsg TF_10003;AHSG_8003 28.77795 28.77795 12.402 23.15909058674368 33.954167497648164 21.97173233131795 19.21665 19.21665 10.3013 12.608208883302972 22.034672201317026 11.961790542839676 38.4788 38.4788 15.4235 32.60511794458042 45.766270178739425 30.93346525961756 0.0 12.402 0.5 28.77795 45.1539;12.402 28.132;10.3013 61.5341;15.4235 1 1 1 24825 TF_10003 45.1539 45.1539 28.132 28.132 61.5341 61.5341 45.1539 28.132 61.5341 1 25373 AHSG_8003 12.402 12.402 10.3013 10.3013 15.4235 15.4235 12.402 10.3013 15.4235 0 Exp 2,1(0.5);Poly 2,1(0.5) 2.5089522543317866 5.2658913135528564 1.8344712257385254 3.431420087814331 1.1292133695819428 2.6329456567764282 -3.318912000000001 60.874812000000006 1.7425640000000016 36.690736 -6.709588000000004 83.66718800000001 CONFLICT 0.5 0.5 0.0 GO:0051172 6 negative regulation of nitrogen compound metabolic process 471 499 47 47 41 43 38 38 124 461 1924 0.91447 0.12046 0.2191 7.62 79426;24522;246273;293615;79224;24794;24648;25106;252922;83516;29441;25513;25591;299282;288001;24516;54404;50693;306251;24471;25675;299626;25112;294515;83928;24360;24890;116636;24330;116663;140942;113936;25695;114851;29184;79431;25377;25373 zfp36;zfp354a;trib3;sirt3;serpind1;serpina3c;serpina1;rgn;pzp;ppargc1a;por;pik3r1;parp1;loc299282;kng1;jun;itih4;itih3;itih1;hspb1;hmgcr;gadd45b;gadd45a;foxo3;fetub;fabp1;esr1;eif4ebp1;egr1;dusp6;ddit4;cpb2;cebpd;cdkn1a;cd36;bhlhe40;ambp;ahsg ZFP36_10204;ZFP354A_10203;TRIB3_10079;SIRT3_9828;SERPIND1_9812;SERPINA3C_32925;SERPINA1_9807;RGN_9699;PZP_9633;PPARGC1A_33189;POR_9531;PIK3R1_32562;PARP1_9425;LOC299282_9119;KNG1L1_34113;JUN_8938;ITIH4_32725;ITIH3_32422;ITIH1_33132;HSPB1_8847;HMGCR_8810;GADD45B_8679;GADD45A_8678;FOXO3_8662;FETUB_33027;FABP1_33091;ESR1_33192;EIF4EBP1_8550;EGR1_8533;DUSP6_8506;DDIT4_8450;CPB2_8369;CEBPD_8283;CDKN1A_8271;CD36_8243;BHLHE40_8141;AMBP_33085;AHSG_8003 38.72570668421053 27.69285 0.306936 33.51313877763198 41.664562114207754 34.66379086840024 26.13653400526316 21.654899999999998 0.0732342 22.528181300020666 28.220172537209347 24.41941720274633 60.229961315789474 41.2117 1.15962 51.040523563884555 62.22815268339037 45.83037367271371 23.5 38.298249999999996 0.348134;0.834827;108.064;2.38018;28.261;29.766;15.797;77.4407;34.1871;42.4094;12.4414;18.7324;26.9741;45.2017;24.3655;16.4324;57.1163;27.1247;98.1741;89.1011;1.63089;106.367;102.919;13.1992;32.5155;33.8478;23.3972;83.9001;0.750017;62.3934;87.5421;25.8316;0.306936;6.24967;48.1296;57.8085;17.2343;12.402 0.118102;0.27095;83.8836;0.56209;22.307;23.347;13.013;58.7732;26.3085;26.2988;8.48981;11.6701;21.799;30.7472;19.538;10.5224;39.6402;21.5108;42.9071;60.3265;0.663137;52.7132;89.5012;5.6804;19.6094;26.4736;18.3088;42.4185;0.186019;39.0875;53.2453;20.4374;0.0732342;2.44025;37.5433;38.3491;14.1233;10.3013 1.15962;2.99857;143.428;8.82917;38.3264;40.8256;19.9134;89.8047;48.5666;81.7305;79.2355;41.5978;35.2797;78.6415;32.1467;39.929;101.869;36.4819;104.278;106.138;7.6286;109.434;115.437;32.7581;49.9875;46.9257;31.9156;107.32;4.70178;133.304;245.492;34.8042;1.73689;19.0606;69.1421;110.58;21.9073;15.4235 7 31 7 293615;25106;25591;299626;24360;116636;29184 SIRT3_9828;RGN_9699;PARP1_9425;GADD45B_8679;FABP1_33091;EIF4EBP1_8550;CD36_8243 54.148497142857146 48.1296 36.56320685774235 34.326127142857146 37.5433 19.875369264305267 66.67648142857142 69.1421 38.1734145187164 2.38018;77.4407;26.9741;106.367;33.8478;83.9001;48.1296 0.56209;58.7732;21.799;52.7132;26.4736;42.4185;37.5433 8.82917;89.8047;35.2797;109.434;46.9257;107.32;69.1421 31 79426;24522;246273;79224;24794;24648;252922;83516;29441;25513;299282;288001;24516;54404;50693;306251;24471;25675;25112;294515;83928;24890;24330;116663;140942;113936;25695;114851;79431;25377;25373 ZFP36_10204;ZFP354A_10203;TRIB3_10079;SERPIND1_9812;SERPINA3C_32925;SERPINA1_9807;PZP_9633;PPARGC1A_33189;POR_9531;PIK3R1_32562;LOC299282_9119;KNG1L1_34113;JUN_8938;ITIH4_32725;ITIH3_32422;ITIH1_33132;HSPB1_8847;HMGCR_8810;GADD45A_8678;FOXO3_8662;FETUB_33027;ESR1_33192;EGR1_8533;DUSP6_8506;DDIT4_8450;CPB2_8369;CEBPD_8283;CDKN1A_8271;BHLHE40_8141;AMBP_33085;AHSG_8003 35.243141096774195 25.8316 32.40041431253625 24.28727103870968 19.6094 22.972824815152478 58.774295483870965 39.929 53.94137188636479 0.348134;0.834827;108.064;28.261;29.766;15.797;34.1871;42.4094;12.4414;18.7324;45.2017;24.3655;16.4324;57.1163;27.1247;98.1741;89.1011;1.63089;102.919;13.1992;32.5155;23.3972;0.750017;62.3934;87.5421;25.8316;0.306936;6.24967;57.8085;17.2343;12.402 0.118102;0.27095;83.8836;22.307;23.347;13.013;26.3085;26.2988;8.48981;11.6701;30.7472;19.538;10.5224;39.6402;21.5108;42.9071;60.3265;0.663137;89.5012;5.6804;19.6094;18.3088;0.186019;39.0875;53.2453;20.4374;0.0732342;2.44025;38.3491;14.1233;10.3013 1.15962;2.99857;143.428;38.3264;40.8256;19.9134;48.5666;81.7305;79.2355;41.5978;78.6415;32.1467;39.929;101.869;36.4819;104.278;106.138;7.6286;115.437;32.7581;49.9875;31.9156;4.70178;133.304;245.492;34.8042;1.73689;19.0606;110.58;21.9073;15.4235 0 Exp 2,12(0.32);Exp 3,2(0.06);Exp 4,3(0.08);Hill,5(0.14);Linear,7(0.19);Poly 2,8(0.22);Power,1(0.03) 1.9171389859833106 76.02302598953247 1.5197933912277222 4.591650485992432 0.7057498938189243 1.7035366892814636 28.07007064605306 49.38134272236798 18.973608976740746 33.29945903378557 44.00142343091808 76.45849920066085 DOWN 0.18421052631578946 0.8157894736842105 0.0 GO:0005981 7 regulation of glycogen catabolic process 2 2 1 1 1 1 1 1 161 1 2384 0.99598 0.12319 0.12319 50.0 192280 ppp1r3b PPP1R3B_9545 36.1411 36.1411 36.1411 36.1411 27.0588 27.0588 27.0588 27.0588 53.6244 53.6244 53.6244 53.6244 0.0 36.1411 0.0 36.1411 36.1411 27.0588 53.6244 0 1 0 1 192280 PPP1R3B_9545 36.1411 36.1411 27.0588 27.0588 53.6244 53.6244 36.1411 27.0588 53.6244 0 Exp 2,1(1) 1.8798987865447998 1.8798987865447998 1.8798987865447998 1.8798987865447998 0.0 1.8798987865447998 36.1411 36.1411 27.0588 27.0588 53.6244 53.6244 DOWN 0.0 1.0 0.0 GO:0031326 6 regulation of cellular biosynthetic process 611 656 53 53 41 45 36 36 126 620 1765 0.16617 0.87713 0.3083 5.49 79426;24522;246273;25357;24825;293615;25106;192280;83516;29441;303612;363465;25513;81819;25591;81525;25493;58954;24516;494344;24471;290556;25112;294515;314322;24890;116636;24330;25428;25146;25695;114851;29184;79431;25698;25287 zfp36;zfp354a;trib3;thrsp;tf;sirt3;rgn;ppp1r3b;ppargc1a;por;polg2;pir;pik3r1;pax8;parp1;nfkbib;nfkbia;klf6;jun;ier2;hspb1;gnl3;gadd45a;foxo3;fos;esr1;eif4ebp1;egr1;cyp7a1;cyp17a1;cebpd;cdkn1a;cd36;bhlhe40;ass1;acadl ZFP36_10204;ZFP354A_10203;TRIB3_10079;THRSP_33314;TF_10003;SIRT3_9828;RGN_9699;PPP1R3B_9545;PPARGC1A_33189;POR_9531;POLG2_9521;PIR_9487;PIK3R1_32562;PAX8_9432;PARP1_9425;NFKBIB_9308;NFKBIA_9307;KLF6_8969;JUN_8938;IER2_32643;HSPB1_8847;GNL3_8735;GADD45A_8678;FOXO3_8662;FOS_8657;ESR1_33192;EIF4EBP1_8550;EGR1_8533;CYP7A1_8430;CYP17A1_32365;CEBPD_8283;CDKN1A_8271;CD36_8243;BHLHE40_8141;ASS1_33159;ACADL_32776 36.64071652777781 31.38125 1.28141E-12 31.448194929025664 39.0606941234574 31.26543129102676 25.82927306111115 24.32025 1.28141E-12 23.435515855974693 28.21861388010778 24.044140669164335 60.439553333333365 46.07745 1.28142E-12 50.19700841840967 59.45390609343533 41.380863987273095 31.5 85.7679 0.348134;0.834827;108.064;32.2053;45.1539;2.38018;77.4407;36.1411;42.4094;12.4414;63.7758;50.0307;18.7324;56.8931;26.9741;30.5572;0.520151;18.9476;16.4324;49.6814;89.1011;87.6357;102.919;13.1992;1.28141E-12;23.3972;83.9001;0.750017;5.72128;49.6922;0.306936;6.24967;48.1296;57.8085;26.8037;33.4878 0.118102;0.27095;83.8836;24.3966;28.132;0.56209;58.7732;27.0588;26.2988;8.48981;40.9553;38.7717;11.6701;45.1162;21.799;24.2439;0.160202;11.6941;10.5224;33.4626;60.3265;54.41;89.5012;5.6804;1.28141E-12;18.3088;42.4185;0.186019;0.985273;35.6654;0.0732342;2.44025;37.5433;38.3491;20.9825;26.6039 1.15962;2.99857;143.428;46.6068;61.5341;8.82917;89.8047;53.6244;81.7305;79.2355;132.567;73.0083;41.5978;81.5688;35.2797;41.2611;2.88499;45.5481;39.929;89.4404;106.138;238.963;115.437;32.7581;1.28142E-12;31.9156;107.32;4.70178;22.3625;81.6409;1.73689;19.0606;69.1421;110.58;36.7081;45.3228 12 24 12 24825;293615;25106;363465;81819;25591;81525;290556;116636;25146;29184;25287 TF_10003;SIRT3_9828;RGN_9699;PIR_9487;PAX8_9432;PARP1_9425;NFKBIB_9308;GNL3_8735;EIF4EBP1_8550;CYP17A1_32365;CD36_8243;ACADL_32776 49.35627333333334 48.9109 24.930430918067437 34.50326583333333 36.60435 15.699028199425978 77.80622249999999 71.0752 57.47356851224177 45.1539;2.38018;77.4407;50.0307;56.8931;26.9741;30.5572;87.6357;83.9001;49.6922;48.1296;33.4878 28.132;0.56209;58.7732;38.7717;45.1162;21.799;24.2439;54.41;42.4185;35.6654;37.5433;26.6039 61.5341;8.82917;89.8047;73.0083;81.5688;35.2797;41.2611;238.963;107.32;81.6409;69.1421;45.3228 24 79426;24522;246273;25357;192280;83516;29441;303612;25513;25493;58954;24516;494344;24471;25112;294515;314322;24890;24330;25428;25695;114851;79431;25698 ZFP36_10204;ZFP354A_10203;TRIB3_10079;THRSP_33314;PPP1R3B_9545;PPARGC1A_33189;POR_9531;POLG2_9521;PIK3R1_32562;NFKBIA_9307;KLF6_8969;JUN_8938;IER2_32643;HSPB1_8847;GADD45A_8678;FOXO3_8662;FOS_8657;ESR1_33192;EGR1_8533;CYP7A1_8430;CEBPD_8283;CDKN1A_8271;BHLHE40_8141;ASS1_33159 30.282938125000047 18.84 32.881530813809384 21.492276675000056 11.6821 25.67140014029418 51.75621875000005 40.763400000000004 44.92832188956352 0.348134;0.834827;108.064;32.2053;36.1411;42.4094;12.4414;63.7758;18.7324;0.520151;18.9476;16.4324;49.6814;89.1011;102.919;13.1992;1.28141E-12;23.3972;0.750017;5.72128;0.306936;6.24967;57.8085;26.8037 0.118102;0.27095;83.8836;24.3966;27.0588;26.2988;8.48981;40.9553;11.6701;0.160202;11.6941;10.5224;33.4626;60.3265;89.5012;5.6804;1.28141E-12;18.3088;0.186019;0.985273;0.0732342;2.44025;38.3491;20.9825 1.15962;2.99857;143.428;46.6068;53.6244;81.7305;79.2355;132.567;41.5978;2.88499;45.5481;39.929;89.4404;106.138;115.437;32.7581;1.28142E-12;31.9156;4.70178;22.3625;1.73689;19.0606;110.58;36.7081 0 Exp 2,15(0.42);Exp 3,1(0.03);Exp 4,3(0.09);Hill,7(0.2);Linear,1(0.03);Poly 2,9(0.25) 1.9644978945013454 74.22131156921387 1.5209722518920898 4.591650485992432 0.7881970991153381 1.844538688659668 26.367639517629442 46.91379353792621 18.17367121482609 33.48487490739622 44.04186391665286 76.83724275001384 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0046903 5 secretion 115 123 12 11 9 8 6 6 156 117 2268 0.32205 0.80778 0.70309 4.88 24384;81718;29184;65054;140668;25303 gc;cdo1;cd36;aqp9;abcc3;abcc2 GC_32893;CDO1_8275;CD36_8243;AQP9_32709;ABCC3_7941;ABCC2_32541 37.521683333333335 40.03675 22.9638 10.19389233775141 38.69996638474771 10.446264766415092 27.7411 28.63645 18.5144 6.907606149745365 28.502899286123853 7.5084398133606705 57.683083333333336 59.037499999999994 30.0179 21.94158897786727 59.81166041284404 21.57669123788538 42.356;22.9638;48.1296;27.7316;37.7175;46.2316 26.3722;18.5144;37.5433;21.9372;30.9007;31.1788 78.7583;30.0179;69.1421;37.4625;48.9329;81.7848 2 4 2 29184;140668 CD36_8243;ABCC3_7941 42.923550000000006 42.923550000000006 7.362466516392382 34.222 34.222 4.697027504709752 59.037499999999994 59.037499999999994 14.290062362355224 48.1296;37.7175 37.5433;30.9007 69.1421;48.9329 4 24384;81718;65054;25303 GC_32893;CDO1_8275;AQP9_32709;ABCC2_32541 34.820750000000004 35.043800000000005 11.22245964290655 24.50065 24.1547 5.492626930410119 57.005875 58.1104 27.064474984300606 42.356;22.9638;27.7316;46.2316 26.3722;18.5144;21.9372;31.1788 78.7583;30.0179;37.4625;81.7848 0 Exp 2,3(0.5);Exp 3,1(0.17);Linear,2(0.34) 2.0935749387539966 12.922958970069885 1.5294301509857178 3.0381598472595215 0.576189008327124 1.9339690208435059 29.36487065801636 45.67849600865031 22.21386393241082 33.268336067589175 40.12615560039421 75.24001106627244 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0045445 5 myoblast differentiation 11 11 2 2 2 2 2 2 160 9 2376 0.97146 0.15174 0.15174 18.18 85253;25675 plg;hmgcr PLG_9501;HMGCR_8810 36.208295 36.208295 1.63089 48.899835102667275 62.10956450584959 32.39509760810641 23.4493685 23.4493685 0.663137 32.22459762267304 40.51809656401114 21.348108499276037 79.1038 79.1038 7.6286 101.08119721332945 132.6444985626741 66.96413685639303 0.0 1.63089 0.5 36.208295 70.7857;1.63089 46.2356;0.663137 150.579;7.6286 0 2 0 2 85253;25675 PLG_9501;HMGCR_8810 36.208295 36.208295 48.899835102667275 23.4493685 23.4493685 32.22459762267304 79.1038 79.1038 101.08119721332945 70.7857;1.63089 46.2356;0.663137 150.579;7.6286 0 Exp 4,1(0.5);Linear,1(0.5) 1.7032590755585957 3.427239179611206 1.5254690647125244 1.9017701148986816 0.26608502435425113 1.713619589805603 -31.5634188 103.98000880000001 -21.211645239999996 68.11038223999999 -60.98759199999998 219.195192 DOWN 0.0 1.0 0.0 GO:0030195 6 negative regulation of blood coagulation 26 26 4 4 4 4 4 4 158 22 2363 0.97838 0.078889 0.078889 15.38 85253;288001;361969;113936 plg;kng1;fga;cpb2 PLG_9501;KNG1L1_34113;FGA_8632;CPB2_8369 37.390775000000005 27.20595 24.3655 22.331724825066694 45.26091183544958 24.35626399678267 27.185000000000002 21.4832 19.538 12.762058495399549 31.82761746670796 13.760569099298651 64.09525000000001 36.827650000000006 32.1467 57.72169315052473 83.47112320635905 63.97901214054377 0.5 25.098550000000003 1.5 27.20595 70.7857;24.3655;28.5803;25.8316 46.2356;19.538;22.529;20.4374 150.579;32.1467;38.8511;34.8042 0 4 0 4 85253;288001;361969;113936 PLG_9501;KNG1L1_34113;FGA_8632;CPB2_8369 37.390775000000005 27.20595 22.331724825066694 27.185000000000002 21.4832 12.762058495399549 64.09525000000001 36.827650000000006 57.72169315052473 70.7857;24.3655;28.5803;25.8316 46.2356;19.538;22.529;20.4374 150.579;32.1467;38.8511;34.8042 0 Exp 2,1(0.25);Linear,3(0.75) 1.7199797200447728 7.010862350463867 1.5254690647125244 2.3804118633270264 0.4187473782797611 1.5524907112121582 15.505684671434643 59.27586532856537 14.678182674508436 39.69181732549157 7.527990712485781 120.66250928751424 DOWN 0.0 1.0 0.0 GO:0015721 7 bile acid and bile salt transport 18 18 7 7 6 7 6 6 156 12 2373 0.99994 5.9037E-4 5.9037E-4 33.33 170698;29500;25428;65054;140668;25303 slco1a2;slc10a2;cyp7a1;aqp9;abcc3;abcc2 SLCO1A2_9886;SLC10A2_9833;CYP7A1_8430;AQP9_32709;ABCC3_7941;ABCC2_32541 46.36399666666667 41.97455 5.72128 33.23522601327793 45.662541916411826 22.602237085425536 33.431945500000005 31.039749999999998 0.985273 26.066740476456616 32.66349794921149 16.990162922577888 72.62578333333335 65.35885 22.3625 43.523689736207615 74.80184478623254 37.07799248814771 0.0 5.72128 0.5 16.72644 104.197;56.585;5.72128;27.7316;37.7175;46.2316 80.3101;35.2796;0.985273;21.9372;30.9007;31.1788 128.412;116.8;22.3625;37.4625;48.9329;81.7848 1 5 1 140668 ABCC3_7941 37.7175 37.7175 30.9007 30.9007 48.9329 48.9329 37.7175 30.9007 48.9329 5 170698;29500;25428;65054;25303 SLCO1A2_9886;SLC10A2_9833;CYP7A1_8430;AQP9_32709;ABCC2_32541 48.093296 46.2316 36.85507751735275 33.9381946 31.1788 29.110505624246645 77.36436 81.7848 46.89865290307386 104.197;56.585;5.72128;27.7316;46.2316 80.3101;35.2796;0.985273;21.9372;31.1788 128.412;116.8;22.3625;37.4625;81.7848 0 Exp 2,3(0.5);Hill,1(0.17);Linear,1(0.17);Poly 2,1(0.17) 2.2151943593780317 14.452476501464844 1.5806894302368164 4.560328960418701 1.1850751226236311 1.8380431532859802 19.770277228589027 72.95771610474429 12.574209114541958 54.28968188545805 37.799578351540084 107.45198831512658 DOWN 0.16666666666666666 0.8333333333333334 0.0 GO:0010959 7 regulation of metal ion transport 108 117 8 7 5 6 4 4 158 113 2272 0.12216 0.94814 0.24267 3.42 24825;362895;25106;81869 tf;stac3;rgn;gstm7 TF_10003;STAC3_9953;RGN_9699;GSTM7_8761 57.037274999999994 54.196600000000004 42.3152 16.459232055065662 56.252504729609925 16.184756719401246 40.25295 37.0533 28.132 13.835137504316089 39.37710941489362 13.793729915958691 84.364475 77.2019 61.5341 27.821006198000234 82.95063824911347 27.821313182252418 45.1539;63.2393;77.4407;42.3152 28.132;42.7031;58.7732;31.4035 61.5341;121.52;89.8047;64.5991 3 1 3 24825;25106;81869 TF_10003;RGN_9699;GSTM7_8761 54.96993333333334 45.1539 19.511946862456668 39.436233333333334 31.4035 16.82600332709267 71.97930000000001 64.5991 15.513130571228997 45.1539;77.4407;42.3152 28.132;58.7732;31.4035 61.5341;89.8047;64.5991 1 362895 STAC3_9953 63.2393 63.2393 42.7031 42.7031 121.52 121.52 63.2393 42.7031 121.52 0 Linear,2(0.5);Poly 2,2(0.5) 1.9968147092278452 8.183661341667175 1.7198865413665771 2.879150867462158 0.5576021192688397 1.79231196641922 40.90722758603568 73.16732241396431 26.69451524577024 53.811384754229756 57.09988892595979 111.62906107404021 UP 0.75 0.25 0.0 GO:0010647 6 positive regulation of cell communication 426 450 34 33 27 29 24 24 138 426 1959 0.19133 0.86327 0.39401 5.33 24825;293615;29441;25513;25591;100359982;24539;24516;63868;25675;81869;24957;29455;299626;25112;289388;361969;24890;29496;24330;65210;25423;29184;246142 tf;sirt3;por;pik3r1;parp1;mpc2;lpl;jun;hspd1;hmgcr;gstm7;glul;gdf15;gadd45b;gadd45a;g0s2;fga;esr1;erbb3;egr1;cyp2j4;ctsc;cd36;bmf TF_10003;SIRT3_9828;POR_9531;PIK3R1_32562;PARP1_9425;MPC2_33219;LPL_32544;JUN_8938;HSPD1_8849;HMGCR_8810;GSTM7_8761;GLUL_32832;GDF15_33113;GADD45B_8679;GADD45A_8678;G0S2_32729;FGA_8632;ESR1_33192;ERBB3_8571;EGR1_8533;CYP2J4_32580;CTSC_32456;CD36_8243;BMF_8152 43.644141125000004 42.28655 0.750017 32.84410517552433 48.233408346576226 32.65875003267297 31.313739833333333 26.039450000000002 0.186019 24.719260598931005 35.79992975520095 26.239564281709058 67.46281875000001 66.86305 4.70178 41.90348890663695 74.24218296897577 42.85551410795529 21.5 104.03399999999999 45.1539;2.38018;12.4414;18.7324;26.9741;46.8463;74.2041;16.4324;42.2579;1.63089;42.3152;26.4669;105.149;106.367;102.919;46.3784;28.5803;23.3972;60.9984;0.750017;17.8395;56.2386;48.1296;94.8767 28.132;0.56209;8.48981;11.6701;21.799;35.8494;49.8682;10.5224;23.9469;0.663137;31.4035;21.0456;85.3487;52.7132;89.5012;33.7914;22.529;18.3088;41.6036;0.186019;14.6501;38.2681;37.5433;73.1342 61.5341;8.82917;79.2355;41.5978;35.2797;69.127;155.425;39.929;102.383;7.6286;64.5991;35.4303;125.652;109.434;115.437;73.6529;38.8511;31.9156;113.972;4.70178;22.6149;102.888;69.1421;109.848 13 11 13 24825;293615;25591;100359982;24539;63868;81869;299626;289388;29496;65210;29184;246142 TF_10003;SIRT3_9828;PARP1_9425;MPC2_33219;LPL_32544;HSPD1_8849;GSTM7_8761;GADD45B_8679;G0S2_32729;ERBB3_8571;CYP2J4_32580;CD36_8243;BMF_8152 50.36317538461538 46.3784 28.71907574757953 34.23053 33.7914 18.235105283208537 76.60315153846153 69.1421 40.99197989171214 45.1539;2.38018;26.9741;46.8463;74.2041;42.2579;42.3152;106.367;46.3784;60.9984;17.8395;48.1296;94.8767 28.132;0.56209;21.799;35.8494;49.8682;23.9469;31.4035;52.7132;33.7914;41.6036;14.6501;37.5433;73.1342 61.5341;8.82917;35.2797;69.127;155.425;102.383;64.5991;109.434;73.6529;113.972;22.6149;69.1421;109.848 11 29441;25513;24516;25675;24957;29455;25112;361969;24890;24330;25423 POR_9531;PIK3R1_32562;JUN_8938;HMGCR_8810;GLUL_32832;GDF15_33113;GADD45A_8678;FGA_8632;ESR1_33192;EGR1_8533;CTSC_32456 35.703464272727274 23.3972 36.92289069514919 27.866624181818178 18.3088 31.340748771683163 56.660607272727276 39.929 42.251611125756874 12.4414;18.7324;16.4324;1.63089;26.4669;105.149;102.919;28.5803;23.3972;0.750017;56.2386 8.48981;11.6701;10.5224;0.663137;21.0456;85.3487;89.5012;22.529;18.3088;0.186019;38.2681 79.2355;41.5978;39.929;7.6286;35.4303;125.652;115.437;38.8511;31.9156;4.70178;102.888 0 Exp 2,6(0.25);Exp 3,1(0.05);Exp 4,1(0.05);Hill,2(0.09);Linear,6(0.25);Poly 2,7(0.3);Power,1(0.05) 1.965047208700173 49.130051255226135 1.5209722518920898 4.21828556060791 0.6881831574836315 1.8215704560279846 30.503762331071336 56.78451991892866 21.42397586990991 41.203503796756756 50.697931593606114 84.22770590639385 CONFLICT 0.5416666666666666 0.4583333333333333 0.0 GO:1903827 6 regulation of cellular protein localization 137 147 8 7 6 7 6 6 156 141 2244 0.16007 0.91755 0.29751 4.08 362895;25513;25591;290556;24957;29184 stac3;pik3r1;parp1;gnl3;glul;cd36 STAC3_9953;PIK3R1_32562;PARP1_9425;GNL3_8735;GLUL_32832;CD36_8243 45.196333333333335 37.55185 18.7324 26.52709471711267 40.80963057689803 19.477767651632917 31.528516666666665 29.67115 11.6701 16.022003368295323 30.07795047206667 12.550041829704659 90.32215000000001 55.36995 35.2797 79.91602021208888 68.63866864826149 50.39258932799311 63.2393;18.7324;26.9741;87.6357;26.4669;48.1296 42.7031;11.6701;21.799;54.41;21.0456;37.5433 121.52;41.5978;35.2797;238.963;35.4303;69.1421 3 3 3 25591;290556;29184 PARP1_9425;GNL3_8735;CD36_8243 54.24646666666666 48.1296 30.78992484569154 37.91743333333333 37.5433 16.308718897060352 114.46159999999999 69.1421 109.14263367222728 26.9741;87.6357;48.1296 21.799;54.41;37.5433 35.2797;238.963;69.1421 3 362895;25513;24957 STAC3_9953;PIK3R1_32562;GLUL_32832 36.1462 26.4669 23.779879589055955 25.1396 21.0456 15.916419171723257 66.1827 41.5978 48.02262063371803 63.2393;18.7324;26.4669 42.7031;11.6701;21.0456 121.52;41.5978;35.4303 0 Exp 2,3(0.5);Linear,2(0.34);Poly 2,1(0.17) 2.104999665364285 12.976505398750305 1.582527995109558 2.879150867462158 0.5499040727280177 2.0854678750038147 23.97023683763426 66.4224298290324 18.70824391623754 44.3487894170958 26.37601588076879 154.2682841192312 CONFLICT 0.5 0.5 0.0 GO:0006694 6 steroid biosynthetic process 45 49 18 18 13 11 8 8 154 41 2344 0.99692 0.010796 0.010796 16.33 293688;65192;29540;289456;25675;25428;25146;25284 tm7sf2;slc27a2;hsd17b7;hsd17b11;hmgcr;cyp7a1;cyp17a1;amacr TM7SF2_10031;SLC27A2_9860;HSD17B7_8834;HSD17B11_8832;HMGCR_8810;CYP7A1_8430;CYP17A1_32365;AMACR_8038 21.55307425 6.671585 0.977494 29.591921548461574 22.89079517415362 27.999544802377518 14.199194 3.33208 0.322682 19.416408617297066 15.738733663415552 17.930150215450077 46.665291249999996 17.8775 3.73641 70.62332481487148 46.485945652255474 69.81585777947556 1.5 1.834315 3.5 6.671585 82.3097;7.62189;0.977494;22.4334;1.63089;5.72128;49.6922;2.03774 51.1696;5.49916;0.322682;18.1233;0.663137;0.985273;35.6654;1.165 209.842;13.3925;5.49472;29.2247;7.6286;22.3625;81.6409;3.73641 4 4 4 65192;289456;25146;25284 SLC27A2_9860;HSD17B11_8832;CYP17A1_32365;AMACR_8038 20.4463075 15.027645 21.312060797753894 15.113215 11.81123 15.475094778500281 31.9986275 21.3086 34.72266700251712 7.62189;22.4334;49.6922;2.03774 5.49916;18.1233;35.6654;1.165 13.3925;29.2247;81.6409;3.73641 4 293688;29540;25675;25428 TM7SF2_10031;HSD17B7_8834;HMGCR_8810;CYP7A1_8430 22.659841 3.676085 39.82194319325051 13.285173 0.824205 25.257733567092583 61.33195500000001 14.99555 99.29031345772574 82.3097;0.977494;1.63089;5.72128 51.1696;0.322682;0.663137;0.985273 209.842;5.49472;7.6286;22.3625 0 Exp 4,3(0.38);Hill,2(0.25);Linear,3(0.38) 2.0522538137763973 17.441644430160522 1.5621941089630127 4.560328960418701 0.9793543144345256 1.8985018730163574 1.0469188226476511 42.05922967735235 0.7443092844119263 27.654078715588074 -2.2741759988050774 95.60475849880508 CONFLICT 0.5 0.5 0.0 GO:0010043 6 response to zinc ion 25 28 4 4 4 4 4 4 158 24 2361 0.97084 0.098068 0.098068 14.29 25591;24567;497840;25698 parp1;mt1;cps1;ass1 PARP1_9425;MT1A_9255;CPS1_32421;ASS1_33159 24.672975 26.8889 12.9315 8.187959007133582 26.89068041617404 5.912159135003847 19.0438575 21.39075 8.91033 6.9192562942769795 21.0318025684559 4.888703413406937 35.260125 35.9939 23.4636 9.091071469808513 37.26887271695436 7.208591026614552 0.5 19.8676 1.5 26.8889 26.9741;12.9315;31.9826;26.8037 21.799;8.91033;24.4836;20.9825 35.2797;23.4636;45.5891;36.7081 1 3 1 25591 PARP1_9425 26.9741 26.9741 21.799 21.799 35.2797 35.2797 26.9741 21.799 35.2797 3 24567;497840;25698 MT1A_9255;CPS1_32421;ASS1_33159 23.905933333333333 26.8037 9.85057823395832 18.125476666666668 20.9825 8.170288940339473 35.2536 36.7081 11.134231686560152 12.9315;31.9826;26.8037 8.91033;24.4836;20.9825 23.4636;45.5891;36.7081 0 Exp 2,3(0.75);Poly 2,1(0.25) 1.9388020703147644 7.789958834648132 1.8086696863174438 2.273383855819702 0.2194586862098055 1.8539526462554932 16.648775173009085 32.69717482699092 12.262986331608559 25.824728668391444 26.350874959587642 44.16937504041236 DOWN 0.25 0.75 0.0 GO:0014065 8 phosphatidylinositol 3-kinase signaling 12 13 2 2 2 2 2 2 160 11 2374 0.95495 0.19842 0.19842 15.38 25513;29496 pik3r1;erbb3 PIK3R1_32562;ERBB3_8571 39.865399999999994 39.865399999999994 18.7324 29.886575213630625 46.397907966857865 28.42287911746234 26.63685 26.63685 11.6701 21.166180834647523 31.263283237731038 20.129566366880198 77.7849 77.7849 41.5978 51.17628760295141 88.970842319949 48.66992707668204 0.0 18.7324 0.5 39.865399999999994 18.7324;60.9984 11.6701;41.6036 41.5978;113.972 1 1 1 29496 ERBB3_8571 60.9984 60.9984 41.6036 41.6036 113.972 113.972 60.9984 41.6036 113.972 1 25513 PIK3R1_32562 18.7324 18.7324 11.6701 11.6701 41.5978 41.5978 18.7324 11.6701 41.5978 0 Linear,1(0.5);Poly 2,1(0.5) 1.637042493605079 3.274882674217224 1.6013026237487793 1.6735800504684448 0.051107858560189255 1.637441337108612 -1.5552800000000033 81.28608 -2.6979799999999976 55.971680000000006 6.8581840000000085 148.711616 CONFLICT 0.5 0.5 0.0 GO:0046677 4 response to antibiotic 202 218 30 30 24 26 20 20 142 198 2187 0.96779 0.056179 0.081218 9.17 286954;25513;24314;25493;58954;24516;81678;63868;24471;24464;25675;25661;361969;24360;116636;24330;25428;25146;81718;54232 ugt2b1;pik3r1;nqo1;nfkbia;klf6;jun;itpr2;hspd1;hspb1;hp;hmgcr;fn1;fga;fabp1;eif4ebp1;egr1;cyp7a1;cyp17a1;cdo1;car3 UGT2B10_33303,UGT2B1_33224;PIK3R1_32562;NQO1_33055;NFKBIA_9307;KLF6_8969;JUN_8938;ITPR2_8931;HSPD1_8849;HSPB1_8847;HP_8823;HMGCR_8810;FN1_8655;FGA_8632;FABP1_33091;EIF4EBP1_8550;EGR1_8533;CYP7A1_8430;CYP17A1_32365;CDO1_8275;CAR3_8196 37.9053894 32.82945 0.520151 28.619969712058204 43.16733680538693 25.308004991561702 24.35908405 24.34055 0.160202 18.310647795387244 27.504229491605102 15.14054843978643 65.728876 46.2369 2.88499 49.43007627779472 70.17033080009716 40.40434439856422 9.5 32.82945 47.47345;18.7324;87.2765;0.520151;18.9476;16.4324;31.8111;42.2579;89.1011;64.9285;1.63089;59.5777;28.5803;33.8478;83.9001;0.750017;5.72128;49.6922;22.9638;53.9626 34.82915;11.6701;60.6992;0.160202;11.6941;10.5224;24.7342;23.9469;60.3265;41.6103;0.663137;31.0499;22.529;26.4736;42.4185;0.186019;0.985273;35.6654;18.5144;28.5034 76.47475;41.5978;197.117;2.88499;45.5481;39.929;44.3296;102.383;106.138;136.455;7.6286;105.243;38.8511;46.9257;107.32;4.70178;22.3625;81.6409;30.0179;77.0288 7 14 6 286954;24314;63868;24360;116636;25146 UGT2B10_33303,UGT2B1_33224;NQO1_33055;HSPD1_8849;FABP1_33091;EIF4EBP1_8550;CYP17A1_32365 57.40799166666667 48.582825 22.52463567764008 37.338791666666665 35.247275 13.251458844837298 101.97689166666667 92.01195 51.33205516028375 47.47345;87.2765;42.2579;33.8478;83.9001;49.6922 34.82915;60.6992;23.9469;26.4736;42.4185;35.6654 76.47475;197.117;102.383;46.9257;107.32;81.6409 14 25513;25493;58954;24516;81678;24471;24464;25675;25661;361969;24330;25428;81718;54232 PIK3R1_32562;NFKBIA_9307;KLF6_8969;JUN_8938;ITPR2_8931;HSPB1_8847;HP_8823;HMGCR_8810;FN1_8655;FGA_8632;EGR1_8533;CYP7A1_8430;CDO1_8275;CAR3_8196 29.54713128571429 20.9557 27.408587824748373 18.796352214285715 15.10425 17.646656183397848 50.19401214285715 40.763400000000004 41.124816736918234 18.7324;0.520151;18.9476;16.4324;31.8111;89.1011;64.9285;1.63089;59.5777;28.5803;0.750017;5.72128;22.9638;53.9626 11.6701;0.160202;11.6941;10.5224;24.7342;60.3265;41.6103;0.663137;31.0499;22.529;0.186019;0.985273;18.5144;28.5034 41.5978;2.88499;45.5481;39.929;44.3296;106.138;136.455;7.6286;105.243;38.8511;4.70178;22.3625;30.0179;77.0288 0 Exp 2,5(0.24);Exp 3,2(0.1);Exp 4,2(0.1);Hill,2(0.1);Linear,4(0.2);Poly 2,5(0.24);Power,1(0.05) 2.0037712730041943 44.70114350318909 1.541895866394043 4.560328960418701 0.9012557272554595 1.7792335748672485 25.362134633131152 50.44864416686886 16.33408882622166 32.38407927377834 44.06518990473084 87.39256209526916 DOWN 0.3 0.7 0.0 GO:0000096 6 sulfur amino acid metabolic process 12 14 2 2 2 2 2 2 160 12 2373 0.94527 0.22236 0.22236 14.29 497840;81718 cps1;cdo1 CPS1_32421;CDO1_8275 27.4732 27.4732 22.9638 6.377254638165248 26.864544094847243 6.318896477886404 21.499 21.499 18.5144 4.220861798258749 21.096153853169174 4.182236756087277 37.8035 37.8035 30.0179 11.01050111121198 36.75263926128591 10.90974418286969 0.0 22.9638 0.5 27.4732 31.9826;22.9638 24.4836;18.5144 45.5891;30.0179 0 2 0 2 497840;81718 CPS1_32421;CDO1_8275 27.4732 27.4732 6.377254638165248 21.499 21.499 4.220861798258749 37.8035 37.8035 11.01050111121198 31.9826;22.9638 24.4836;18.5144 45.5891;30.0179 0 Exp 2,1(0.5);Linear,1(0.5) 1.9155516207196297 3.8354474306106567 1.8264755010604858 2.008971929550171 0.12904446212738216 1.9177237153053284 18.634775999999995 36.311624 15.649183999999998 27.348816 22.543724 53.063276 DOWN 0.0 1.0 0.0 GO:0043279 6 response to alkaloid 71 74 8 8 8 6 6 6 156 68 2317 0.8124 0.33 0.46898 8.11 83516;63868;81869;361969;24330;312382 ppargc1a;hspd1;gstm7;fga;egr1;abcg2 PPARGC1A_33189;HSPD1_8849;GSTM7_8761;FGA_8632;EGR1_8533;ABCG2_32656 26.9215595 35.4191 0.750017 19.343472488152933 25.154107514291383 18.924234958969052 17.849649833333334 23.237949999999998 0.186019 13.074128412059139 16.84570753694935 12.844994457708392 50.608579999999996 51.725100000000005 4.70178 39.06144524909441 46.636393719725326 38.28988191611548 2.5 35.4191 42.4094;42.2579;42.3152;28.5803;0.750017;5.21654 26.2988;23.9469;31.4035;22.529;0.186019;2.73368 81.7305;102.383;64.5991;38.8511;4.70178;11.386 3 3 3 63868;81869;312382 HSPD1_8849;GSTM7_8761;ABCG2_32656 29.929879999999997 42.2579 21.402399428316443 19.36136 23.9469 14.874811848450385 59.45603333333333 64.5991 45.71599122083359 42.2579;42.3152;5.21654 23.9469;31.4035;2.73368 102.383;64.5991;11.386 3 83516;361969;24330 PPARGC1A_33189;FGA_8632;EGR1_8533 23.913239 28.5803 21.21820307586066 16.337939666666667 22.529 14.114398815632226 41.76112666666667 38.8511 38.59672418237244 42.4094;28.5803;0.750017 26.2988;22.529;0.186019 81.7305;38.8511;4.70178 0 Exp 2,1(0.17);Exp 3,1(0.17);Exp 4,1(0.17);Hill,1(0.17);Linear,2(0.34) 2.019893770364259 13.027243852615356 1.5074360370635986 4.21828556060791 1.037496679305034 1.7538878917694092 11.44355793315052 42.39956106684948 7.388168309218129 28.311131357448538 19.352914237858474 81.86424576214155 CONFLICT 0.5 0.5 0.0 GO:0006351 7 transcription, DNA-templated 63 70 8 8 7 7 6 6 156 64 2321 0.8465 0.28426 0.45022 8.57 81819;24516;294515;314322;24890;24330 pax8;jun;foxo3;fos;esr1;egr1 PAX8_9432;JUN_8938;FOXO3_8662;FOS_8657;ESR1_33192;EGR1_8533 18.445319500000213 14.8158 1.28141E-12 20.91736170078703 24.76174989210024 26.556602344762094 13.30230316666688 8.1014 1.28141E-12 17.04111787202276 18.78765058147683 21.550480250594617 31.812213333333546 32.33685 1.28142E-12 29.28992333750723 39.782463272394246 36.16977324163883 2.5 14.8158 56.8931;16.4324;13.1992;1.28141E-12;23.3972;0.750017 45.1162;10.5224;5.6804;1.28141E-12;18.3088;0.186019 81.5688;39.929;32.7581;1.28142E-12;31.9156;4.70178 1 5 1 81819 PAX8_9432 56.8931 56.8931 45.1162 45.1162 81.5688 81.5688 56.8931 45.1162 81.5688 5 24516;294515;314322;24890;24330 JUN_8938;FOXO3_8662;FOS_8657;ESR1_33192;EGR1_8533 10.755763400000257 13.1992 10.171060811886385 6.939523800000257 5.6804 7.704700733554015 21.86089600000026 31.9156 18.156517738296237 16.4324;13.1992;1.28141E-12;23.3972;0.750017 10.5224;5.6804;1.28141E-12;18.3088;0.186019 39.929;32.7581;1.28142E-12;31.9156;4.70178 0 Exp 2,2(0.34);Exp 4,1(0.17);Hill,2(0.34);Poly 2,1(0.17) 2.263247124813269 14.270985126495361 1.7521979808807373 4.21828556060791 0.9300394356213006 1.9834235906600952 1.7079442754934604 35.182694724506966 -0.3334310214722098 26.93803735480597 8.375393517837885 55.249033148829206 DOWN 0.16666666666666666 0.8333333333333334 0.0 GO:0043278 5 response to morphine 18 18 3 3 3 2 2 2 160 16 2369 0.89794 0.31912 0.31912 11.11 361969;312382 fga;abcg2 FGA_8632;ABCG2_32656 16.89842 16.89842 5.21654 16.52067313001501 17.56887940301948 16.493441394888013 12.63134 12.63134 2.73368 13.997405007757688 13.199397471476315 13.974332483857678 25.11855 25.11855 11.386 19.420758455966656 25.906703728247095 19.38874638563052 0.0 5.21654 0.5 16.89842 28.5803;5.21654 22.529;2.73368 38.8511;11.386 1 1 1 312382 ABCG2_32656 5.21654 5.21654 2.73368 2.73368 11.386 11.386 5.21654 2.73368 11.386 1 361969 FGA_8632 28.5803 28.5803 22.529 22.529 38.8511 38.8511 28.5803 22.529 38.8511 0 Exp 4,1(0.5);Linear,1(0.5) 1.5245685928818618 3.0493319034576416 1.5074360370635986 1.541895866394043 0.024366778998088274 1.5246659517288208 -5.998064799999998 39.7949048 -6.768073599999999 32.0307536 -1.7972479999999997 52.034347999999994 CONFLICT 0.5 0.5 0.0 GO:0035296 6 regulation of tube diameter 54 57 7 7 5 6 4 4 158 53 2332 0.70503 0.49592 0.78169 7.02 288001;25675;361969;497840 kng1;hmgcr;fga;cps1 KNG1L1_34113;HMGCR_8810;FGA_8632;CPS1_32421 21.6398225 26.472900000000003 1.63089 13.69829639001477 27.662825418736485 8.32367340072776 16.80343425 21.0335 0.663137 10.950709174363654 21.544588677575828 6.567531691931655 31.053875 35.498900000000006 7.6286 16.55301844385187 38.59905157501023 10.464299149321175 1.5 26.472900000000003 24.3655;1.63089;28.5803;31.9826 19.538;0.663137;22.529;24.4836 32.1467;7.6286;38.8511;45.5891 0 4 0 4 288001;25675;361969;497840 KNG1L1_34113;HMGCR_8810;FGA_8632;CPS1_32421 21.6398225 26.472900000000003 13.69829639001477 16.80343425 21.0335 10.950709174363654 31.053875 35.498900000000006 16.55301844385187 24.3655;1.63089;28.5803;31.9826 19.538;0.663137;22.529;24.4836 32.1467;7.6286;38.8511;45.5891 0 Exp 2,1(0.25);Exp 4,1(0.25);Linear,2(0.5) 1.8895994548611612 7.650553345680237 1.541895866394043 2.3804118633270264 0.34823565009545543 1.8641228079795837 8.215492037785527 35.06415296221448 6.071739259123623 27.53512924087638 14.831916925025173 47.27583307497483 DOWN 0.0 1.0 0.0 GO:0097746 6 regulation of blood vessel diameter 54 57 7 7 5 6 4 4 158 53 2332 0.70503 0.49592 0.78169 7.02 288001;25675;361969;497840 kng1;hmgcr;fga;cps1 KNG1L1_34113;HMGCR_8810;FGA_8632;CPS1_32421 21.6398225 26.472900000000003 1.63089 13.69829639001477 27.662825418736485 8.32367340072776 16.80343425 21.0335 0.663137 10.950709174363654 21.544588677575828 6.567531691931655 31.053875 35.498900000000006 7.6286 16.55301844385187 38.59905157501023 10.464299149321175 1.5 26.472900000000003 24.3655;1.63089;28.5803;31.9826 19.538;0.663137;22.529;24.4836 32.1467;7.6286;38.8511;45.5891 0 4 0 4 288001;25675;361969;497840 KNG1L1_34113;HMGCR_8810;FGA_8632;CPS1_32421 21.6398225 26.472900000000003 13.69829639001477 16.80343425 21.0335 10.950709174363654 31.053875 35.498900000000006 16.55301844385187 24.3655;1.63089;28.5803;31.9826 19.538;0.663137;22.529;24.4836 32.1467;7.6286;38.8511;45.5891 0 Exp 2,1(0.25);Exp 4,1(0.25);Linear,2(0.5) 1.8895994548611612 7.650553345680237 1.541895866394043 2.3804118633270264 0.34823565009545543 1.8641228079795837 8.215492037785527 35.06415296221448 6.071739259123623 27.53512924087638 14.831916925025173 47.27583307497483 DOWN 0.0 1.0 0.0 GO:0006721 6 terpenoid metabolic process 29 34 10 10 7 7 4 4 158 30 2355 0.93913 0.16664 0.27209 11.76 24856;25675;65210;65183 ttr;hmgcr;cyp2j4;aldh3a2 TTR_10102;HMGCR_8810;CYP2J4_32580;ALDH3A2_8024 27.3047225 30.4737 1.63089 21.388101754667826 33.55356578041597 17.019849412624044 18.944559249999998 21.61885 0.663137 14.293347922532904 23.403190914872077 10.471998885138374 40.065975 43.16475 7.6286 29.464720124059667 47.70075618903 25.258440570108217 0.5 9.735195000000001 2.5 44.87425 46.6406;1.63089;17.8395;43.1079 28.5876;0.663137;14.6501;31.8774 63.7146;7.6286;22.6149;66.3058 3 1 3 24856;65210;65183 TTR_10102;CYP2J4_32580;ALDH3A2_8024 35.86266666666666 43.1079 15.708147403285132 25.038366666666665 28.5876 9.145641544655756 50.878433333333334 63.7146 24.511202882015674 46.6406;17.8395;43.1079 28.5876;14.6501;31.8774 63.7146;22.6149;66.3058 1 25675 HMGCR_8810 1.63089 1.63089 0.663137 0.663137 7.6286 7.6286 1.63089 0.663137 7.6286 0 Exp 4,1(0.25);Linear,2(0.5);Poly 2,1(0.25) 2.1456251629499836 9.155028104782104 1.520427942276001 3.8079800605773926 1.0296529208204632 1.9133100509643555 6.34438278042553 48.265062219574475 4.937078285917753 32.952040214082245 11.190549278421521 68.94140072157847 UP 0.75 0.25 0.0 GO:2000177 6 regulation of neural precursor cell proliferation 27 29 2 2 2 2 2 2 160 27 2358 0.72053 0.55973 0.70682 6.9 24825;294515 tf;foxo3 TF_10003;FOXO3_8662 29.17655 29.17655 13.1992 22.59538506078178 38.72136562000456 18.12027636669028 16.906200000000002 16.906200000000002 5.6804 15.875678608487888 23.612455492121487 12.731435340478344 47.146100000000004 47.146100000000004 32.7581 20.347704735424074 55.74144322904773 16.317758349409612 0.5 29.17655 45.1539;13.1992 28.132;5.6804 61.5341;32.7581 1 1 1 24825 TF_10003 45.1539 45.1539 28.132 28.132 61.5341 61.5341 45.1539 28.132 61.5341 1 294515 FOXO3_8662 13.1992 13.1992 5.6804 5.6804 32.7581 32.7581 13.1992 5.6804 32.7581 0 Exp 4,1(0.5);Poly 2,1(0.5) 1.909857313924324 3.822812557220459 1.8344712257385254 1.9883413314819336 0.10880259519305507 1.9114062786102295 -2.1390560000000036 60.492156 -5.096368000000002 38.908767999999995 18.94562 75.34658 CONFLICT 0.5 0.5 0.0 GO:0060348 5 bone development 20 20 3 3 3 2 2 2 160 18 2367 0.86982 0.36669 0.36669 10.0 294103;24890 papss2;esr1 PAPSS2_33237;ESR1_33192 28.920749999999998 28.920749999999998 23.3972 7.811479322445919 30.415634170212765 7.519963553122747 22.0139 22.0139 18.3088 5.239802669948573 23.016641957446808 5.044259029188692 41.5085 41.5085 31.9156 13.566409282488854 44.10470612765958 13.060125891636892 0.0 23.3972 1.0 34.4443 34.4443;23.3972 25.719;18.3088 51.1014;31.9156 0 2 0 2 294103;24890 PAPSS2_33237;ESR1_33192 28.920749999999998 28.920749999999998 7.811479322445919 22.0139 22.0139 5.239802669948573 41.5085 41.5085 13.566409282488854 34.4443;23.3972 25.719;18.3088 51.1014;31.9156 0 Exp 2,2(1) 2.0977797016944586 4.2427738904953 1.8057876825332642 2.436986207962036 0.4463247576056341 2.12138694524765 18.094592000000002 39.74690799999999 14.751904 29.275896 22.706416 60.31058399999999 DOWN 0.0 1.0 0.0 GO:0044344 6 cellular response to fibroblast growth factor stimulus 25 26 3 3 3 2 2 2 160 24 2361 0.7731 0.50003 0.67957 7.69 79426;497840 zfp36;cps1 ZFP36_10204;CPS1_32421 16.165367 16.165367 0.348134 22.36894542781528 22.874628745495496 20.256883600727917 12.300851 12.300851 0.118102 17.229008862787264 17.46845849624625 15.60225662920211 23.37436 23.37436 1.15962 31.416386592592097 32.797278993994 28.450071033311225 0.5 16.165367 0.348134;31.9826 0.118102;24.4836 1.15962;45.5891 0 2 0 2 79426;497840 ZFP36_10204;CPS1_32421 16.165367 16.165367 22.36894542781528 12.300851 12.300851 17.229008862787264 23.37436 23.37436 31.416386592592097 0.348134;31.9826 0.118102;24.4836 1.15962;45.5891 0 Exp 2,1(0.5);Hill,1(0.5) 1.8814972541065906 3.7646520137786865 1.8264755010604858 1.9381765127182007 0.07898454280856776 1.8823260068893433 -14.836409679999996 47.167143679999995 -11.577337039999994 36.17903903999999 -20.1665304 66.9152504 DOWN 0.0 1.0 0.0 GO:2000241 4 regulation of reproductive process 54 57 4 4 3 3 2 2 160 55 2330 0.28577 0.88772 0.58074 3.51 25106;24890 rgn;esr1 RGN_9699;ESR1_33192 50.41895 50.41895 23.3972 38.214525329055185 64.0451021691974 33.00008939758732 38.541000000000004 38.541000000000004 18.3088 28.612651636644937 48.74341234996385 24.70840743881746 60.86015 60.86015 31.9156 40.933775166786184 75.45590500361533 35.348293044415534 77.4407;23.3972 58.7732;18.3088 89.8047;31.9156 1 1 1 25106 RGN_9699 77.4407 77.4407 58.7732 58.7732 89.8047 89.8047 77.4407 58.7732 89.8047 1 24890 ESR1_33192 23.3972 23.3972 18.3088 18.3088 31.9156 31.9156 23.3972 18.3088 31.9156 0 Exp 2,1(0.5);Poly 2,1(0.5) 2.0472761857086788 4.156872749328613 1.7198865413665771 2.436986207962036 0.5070660370362614 2.0784363746643066 -2.543679999999995 103.38158 -1.1141119999999916 78.196112 4.128832000000003 117.59146799999999 CONFLICT 0.5 0.5 0.0 GO:0034105 6 positive regulation of tissue remodeling 16 16 4 4 3 3 3 3 159 13 2372 0.98429 0.076773 0.076773 18.75 24825;58954;25373 tf;klf6;ahsg TF_10003;KLF6_8969;AHSG_8003 25.501166666666666 18.9476 12.402 17.331580004238884 30.281962121642746 18.327590408194837 16.709133333333334 11.6941 10.3013 9.916974595275178 19.504266441665482 10.521282544502279 40.83523333333333 45.5481 15.4235 23.41378210057773 45.71288250675004 23.282110744873524 0.0 12.402 0.5 15.674800000000001 45.1539;18.9476;12.402 28.132;11.6941;10.3013 61.5341;45.5481;15.4235 1 2 1 24825 TF_10003 45.1539 45.1539 28.132 28.132 61.5341 61.5341 45.1539 28.132 61.5341 2 58954;25373 KLF6_8969;AHSG_8003 15.674800000000001 15.674800000000001 4.628438146934662 10.9977 10.9977 0.9848583248366165 30.485799999999998 30.485799999999998 21.30130894053228 18.9476;12.402 11.6941;10.3013 45.5481;15.4235 0 Exp 2,1(0.34);Poly 2,2(0.67) 2.147832883171218 6.839934587478638 1.5740432739257812 3.431420087814331 1.005643824865558 1.8344712257385254 5.888637600046099 45.11369573328723 5.487020147160875 27.93124651950579 14.3400446722424 67.33042199442427 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0042493 4 response to drug 436 472 67 67 51 62 47 47 115 425 1960 0.99974 5.2047E-4 7.5993E-4 9.96 24522;286954;170698;29482;83516;29441;298199;24651;25513;24314;25493;24539;58954;24516;81678;63868;24471;29540;24464;25675;113965;81869;294515;314322;25661;361969;24360;29496;116636;24330;116663;140942;25428;25146;83842;497840;113936;170945;81718;114851;29184;54232;25698;192272;24158;312382;25303 zfp354a;ugt2b1;slco1a2;slc1a2;ppargc1a;por;plin2;pklr;pik3r1;nqo1;nfkbia;lpl;klf6;jun;itpr2;hspd1;hspb1;hsd17b7;hp;hmgcr;hadh;gstm7;foxo3;fos;fn1;fga;fabp1;erbb3;eif4ebp1;egr1;dusp6;ddit4;cyp7a1;cyp17a1;crot;cps1;cpb2;chrna2;cdo1;cdkn1a;cd36;car3;ass1;acot2;acadm;abcg2;abcc2 ZFP354A_10203;UGT2B10_33303,UGT2B1_33224;SLCO1A2_9886;SLC1A2_33059;PPARGC1A_33189;POR_9531;PLIN2_9502;PKLR_9489;PIK3R1_32562;NQO1_33055;NFKBIA_9307;LPL_32544;KLF6_8969;JUN_8938;ITPR2_8931;HSPD1_8849;HSPB1_8847;HSD17B7_8834;HP_8823;HMGCR_8810;HADH_8776;GSTM7_8761;FOXO3_8662;FOS_8657;FN1_8655;FGA_8632;FABP1_33091;ERBB3_8571;EIF4EBP1_8550;EGR1_8533;DUSP6_8506;DDIT4_8450;CYP7A1_8430;CYP17A1_32365;CROT_8384;CPS1_32421;CPB2_8369;CHRNA2_32401;CDO1_8275;CDKN1A_8271;CD36_8243;CAR3_8196;ASS1_33159;ACOT2_7969;ACADM_7957;ABCG2_32656;ABCC2_32541 34.521841893617044 28.5803 1.28141E-12 27.95936619543818 36.647883232626995 25.542296659829358 23.40341729787237 22.529 1.28141E-12 18.97042010204082 24.65326897314715 16.734565469306347 61.623049148936204 45.5481 1.28142E-12 53.229875158482386 63.28557111817213 45.89139815316643 22.5 27.692 0.834827;47.47345;104.197;13.3235;42.4094;12.4414;25.6517;23.0963;18.7324;87.2765;0.520151;74.2041;18.9476;16.4324;31.8111;42.2579;89.1011;0.977494;64.9285;1.63089;33.3125;42.3152;13.1992;1.28141E-12;59.5777;28.5803;33.8478;60.9984;83.9001;0.750017;62.3934;87.5421;5.72128;49.6922;7.4229;31.9826;25.8316;49.3913;22.9638;6.24967;48.1296;53.9626;26.8037;8.54905;11.7137;5.21654;46.2316 0.27095;34.82915;80.3101;9.10952;26.2988;8.48981;20.9252;17.4625;11.6701;60.6992;0.160202;49.8682;11.6941;10.5224;24.7342;23.9469;60.3265;0.322682;41.6103;0.663137;25.7336;31.4035;5.6804;1.28141E-12;31.0499;22.529;26.4736;41.6036;42.4185;0.186019;39.0875;53.2453;0.985273;35.6654;5.75707;24.4836;20.4374;41.8524;18.5144;2.44025;37.5433;28.5034;20.9825;7.19676;8.36151;2.73368;31.1788 2.99857;76.47475;128.412;24.6773;81.7305;79.2355;33.0375;32.9443;41.5978;197.117;2.88499;155.425;45.5481;39.929;44.3296;102.383;106.138;5.49472;136.455;7.6286;46.9856;64.5991;32.7581;1.28142E-12;105.243;38.8511;46.9257;113.972;107.32;4.70178;133.304;245.492;22.3625;81.6409;10.316;45.5891;34.8042;62.472;30.0179;19.0606;69.1421;77.0288;36.7081;10.4125;18.9642;11.386;81.7848 18 30 17 286954;298199;24314;24539;63868;113965;81869;24360;29496;116636;25146;83842;170945;29184;192272;24158;312382 UGT2B10_33303,UGT2B1_33224;PLIN2_9502;NQO1_33055;LPL_32544;HSPD1_8849;HADH_8776;GSTM7_8761;FABP1_33091;ERBB3_8571;EIF4EBP1_8550;CYP17A1_32365;CROT_8384;CHRNA2_32401;CD36_8243;ACOT2_7969;ACADM_7957;ABCG2_32656 41.844290588235296 42.3152 25.469014780305955 29.235974705882352 31.4035 16.46949263732915 71.09254999999999 64.5991 52.23520935097323 47.47345;25.6517;87.2765;74.2041;42.2579;33.3125;42.3152;33.8478;60.9984;83.9001;49.6922;7.4229;49.3913;48.1296;8.54905;11.7137;5.21654 34.82915;20.9252;60.6992;49.8682;23.9469;25.7336;31.4035;26.4736;41.6036;42.4185;35.6654;5.75707;41.8524;37.5433;7.19676;8.36151;2.73368 76.47475;33.0375;197.117;155.425;102.383;46.9856;64.5991;46.9257;113.972;107.32;81.6409;10.316;62.472;69.1421;10.4125;18.9642;11.386 30 24522;170698;29482;83516;29441;24651;25513;25493;58954;24516;81678;24471;29540;24464;25675;294515;314322;25661;361969;24330;116663;140942;25428;497840;113936;81718;114851;54232;25698;25303 ZFP354A_10203;SLCO1A2_9886;SLC1A2_33059;PPARGC1A_33189;POR_9531;PKLR_9489;PIK3R1_32562;NFKBIA_9307;KLF6_8969;JUN_8938;ITPR2_8931;HSPB1_8847;HSD17B7_8834;HP_8823;HMGCR_8810;FOXO3_8662;FOS_8657;FN1_8655;FGA_8632;EGR1_8533;DUSP6_8506;DDIT4_8450;CYP7A1_8430;CPS1_32421;CPB2_8369;CDO1_8275;CDKN1A_8271;CAR3_8196;ASS1_33159;ABCC2_32541 30.37245430000004 23.03005 28.85913409049666 20.09830143333338 17.98845 19.747016812118975 56.25699866666671 39.39005 53.9133337020475 0.834827;104.197;13.3235;42.4094;12.4414;23.0963;18.7324;0.520151;18.9476;16.4324;31.8111;89.1011;0.977494;64.9285;1.63089;13.1992;1.28141E-12;59.5777;28.5803;0.750017;62.3934;87.5421;5.72128;31.9826;25.8316;22.9638;6.24967;53.9626;26.8037;46.2316 0.27095;80.3101;9.10952;26.2988;8.48981;17.4625;11.6701;0.160202;11.6941;10.5224;24.7342;60.3265;0.322682;41.6103;0.663137;5.6804;1.28141E-12;31.0499;22.529;0.186019;39.0875;53.2453;0.985273;24.4836;20.4374;18.5144;2.44025;28.5034;20.9825;31.1788 2.99857;128.412;24.6773;81.7305;79.2355;32.9443;41.5978;2.88499;45.5481;39.929;44.3296;106.138;5.49472;136.455;7.6286;32.7581;1.28142E-12;105.243;38.8511;4.70178;133.304;245.492;22.3625;45.5891;34.8042;30.0179;19.0606;77.0288;36.7081;81.7848 0 Exp 2,16(0.34);Exp 3,2(0.05);Exp 4,6(0.13);Hill,4(0.09);Linear,9(0.19);Poly 2,10(0.21);Power,1(0.03) 2.071529815519386 111.80874145030975 1.5074360370635986 11.836054801940918 1.6870762797375667 1.8028545379638672 26.52838817734419 42.5152956098899 17.979861770756855 28.82697282498789 46.4048735855812 76.84122471229121 DOWN 0.3617021276595745 0.6382978723404256 0.0 GO:0050848 7 regulation of calcium-mediated signaling 33 35 3 3 3 3 3 3 159 32 2353 0.82057 0.38653 0.48519 8.57 25106;81869;29496 rgn;gstm7;erbb3 RGN_9699;GSTM7_8761;ERBB3_8571 60.25143333333333 60.9984 42.3152 17.57465951201709 60.496738699633696 16.992801613199624 43.92676666666667 41.6036 31.4035 13.831953840413616 43.93114504884005 13.419378282143548 89.45859999999999 89.8047 64.5991 24.68826953251284 91.17603134310134 24.872525236125497 0.5 51.6568 77.4407;42.3152;60.9984 58.7732;31.4035;41.6036 89.8047;64.5991;113.972 3 0 3 25106;81869;29496 RGN_9699;GSTM7_8761;ERBB3_8571 60.25143333333333 60.9984 17.57465951201709 43.92676666666667 41.6036 13.831953840413616 89.45859999999999 89.8047 24.68826953251284 77.4407;42.3152;60.9984 58.7732;31.4035;41.6036 89.8047;64.5991;113.972 0 0 Linear,2(0.67);Poly 2,1(0.34) 1.6892077001118153 5.071341872215271 1.6013026237487793 1.7501527070999146 0.07867076290827746 1.7198865413665771 40.3638339089823 80.13903275768436 28.274437411231347 59.579095922102 61.521193041572275 117.3960069584277 UP 1.0 0.0 0.0 GO:0072305 8 negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis 1 1 1 1 1 1 1 1 161 0 2385 1.0 0.063604 0.063604 100.0 81819 pax8 PAX8_9432 56.8931 56.8931 56.8931 56.8931 45.1162 45.1162 45.1162 45.11619999999999 81.5688 81.5688 81.5688 81.56879999999998 0.0 56.8931 0.0 56.8931 56.8931 45.1162 81.5688 1 0 1 81819 PAX8_9432 56.8931 56.8931 45.1162 45.1162 81.5688 81.5688 56.8931 45.1162 81.5688 0 0 Exp 2,1(1) 1.7521979808807373 1.7521979808807373 1.7521979808807373 1.7521979808807373 0.0 1.7521979808807373 56.8931 56.8931 45.1162 45.1162 81.5688 81.5688 UP 1.0 0.0 0.0 GO:0072307 8 regulation of metanephric nephron tubule epithelial cell differentiation 1 1 1 1 1 1 1 1 161 0 2385 1.0 0.063604 0.063604 100.0 81819 pax8 PAX8_9432 56.8931 56.8931 56.8931 56.8931 45.1162 45.1162 45.1162 45.11619999999999 81.5688 81.5688 81.5688 81.56879999999998 0.0 56.8931 0.0 56.8931 56.8931 45.1162 81.5688 1 0 1 81819 PAX8_9432 56.8931 56.8931 45.1162 45.1162 81.5688 81.5688 56.8931 45.1162 81.5688 0 0 Exp 2,1(1) 1.7521979808807373 1.7521979808807373 1.7521979808807373 1.7521979808807373 0.0 1.7521979808807373 56.8931 56.8931 45.1162 45.1162 81.5688 81.5688 UP 1.0 0.0 0.0 GO:0045834 6 positive regulation of lipid metabolic process 76 82 11 11 8 11 8 8 154 74 2311 0.92698 0.14665 0.24292 9.76 293615;25106;83516;29441;24360;25428;25146;29184 sirt3;rgn;ppargc1a;por;fabp1;cyp7a1;cyp17a1;cd36 SIRT3_9828;RGN_9699;PPARGC1A_33189;POR_9531;FABP1_33091;CYP7A1_8430;CYP17A1_32365;CD36_8243 34.00782 38.1286 2.38018 25.82357199233068 36.902071893909245 24.52017352264653 24.348934125000003 26.386200000000002 0.56209 20.20850735418842 26.995519628756973 19.115588488602405 59.95888375 74.1888 8.82917 30.44527836503386 64.0250723086684 27.561358083175143 3.5 38.1286 2.38018;77.4407;42.4094;12.4414;33.8478;5.72128;49.6922;48.1296 0.56209;58.7732;26.2988;8.48981;26.4736;0.985273;35.6654;37.5433 8.82917;89.8047;81.7305;79.2355;46.9257;22.3625;81.6409;69.1421 5 3 5 293615;25106;24360;25146;29184 SIRT3_9828;RGN_9699;FABP1_33091;CYP17A1_32365;CD36_8243 42.298096 48.1296 27.33372161377006 31.803518000000004 35.6654 21.092995440053553 59.268514 69.1421 32.50747026395593 2.38018;77.4407;33.8478;49.6922;48.1296 0.56209;58.7732;26.4736;35.6654;37.5433 8.82917;89.8047;46.9257;81.6409;69.1421 3 83516;29441;25428 PPARGC1A_33189;POR_9531;CYP7A1_8430 20.190693333333332 12.4414 19.53313076949349 11.924627666666666 8.48981 13.001620729638532 61.109500000000004 79.2355 33.57906733368275 42.4094;12.4414;5.72128 26.2988;8.48981;0.985273 81.7305;79.2355;22.3625 0 Exp 2,3(0.38);Hill,2(0.25);Linear,1(0.13);Poly 2,2(0.25) 2.112985057824786 17.995797395706177 1.5209722518920898 4.560328960418701 0.9926480579829934 1.8923738598823547 16.112997587168696 51.90264241283131 10.34515298895125 38.35271526104876 38.86138221871303 81.05638528128696 UP 0.625 0.375 0.0 GO:0019748 3 secondary metabolic process 18 25 3 3 3 3 3 3 159 22 2363 0.92992 0.20982 0.20982 12.0 25256;24894;25303 fmo1;cyp2a1;abcc2 FMO1_32787;CYP2A1_32717;ABCC2_32541 55.63483333333334 55.3937 46.2316 9.526089197741817 57.13025872102069 9.90172366773609 36.57046666666667 38.7444 31.1788 4.698396715192706 36.9915278979306 4.617094297212082 87.19440000000002 82.9415 81.7848 8.387932904476406 86.20487161972925 7.734096193415782 0.5 50.812650000000005 1.5 60.33645 65.2792;55.3937;46.2316 39.7882;38.7444;31.1788 82.9415;96.8569;81.7848 2 1 2 25256;24894 FMO1_32787;CYP2A1_32717 60.33645 60.33645 6.990104085419648 39.2663 39.2663 0.738078058202713 89.89920000000001 89.89920000000001 9.839673702923143 65.2792;55.3937 39.7882;38.7444 82.9415;96.8569 1 25303 ABCC2_32541 46.2316 46.2316 31.1788 31.1788 81.7848 81.7848 46.2316 31.1788 81.7848 0 Exp 2,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 1.8343379908322932 5.516602635383606 1.672747254371643 1.984889268875122 0.15703860544921153 1.8589661121368408 44.85504861455771 66.41461805210896 31.253730274445424 41.88720305888791 77.70256037212569 96.68623962787431 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0008637 7 apoptotic mitochondrial changes 27 27 3 3 3 3 3 3 159 24 2361 0.91178 0.24424 0.24424 11.11 24516;63868;170465 jun;hspd1;acaa2 JUN_8938;HSPD1_8849;ACAA2_7955 28.425833333333333 26.5872 16.4324 13.010555021340679 29.932626240975992 11.840606457767297 18.612933333333334 21.3695 10.5224 7.124134677512294 20.091948738037942 6.009726334279157 59.11756666666667 39.929 35.0407 37.54859731552342 59.08231833342661 38.344736488350165 0.5 21.5098 1.5 34.42255 16.4324;42.2579;26.5872 10.5224;23.9469;21.3695 39.929;102.383;35.0407 2 1 2 63868;170465 HSPD1_8849;ACAA2_7955 34.42255 34.42255 11.080858235940028 22.6582 22.6582 1.8224970178301418 68.71185 68.71185 47.618196990698834 42.2579;26.5872 23.9469;21.3695 102.383;35.0407 1 24516 JUN_8938 16.4324 16.4324 10.5224 10.5224 39.929 39.929 16.4324 10.5224 39.929 0 Exp 2,1(0.34);Exp 3,1(0.34);Poly 2,1(0.34) 2.3283966863306538 7.063665866851807 1.9785058498382568 2.8333094120025635 0.4365586690807424 2.2518506050109863 13.70300434333347 43.1486623233332 10.551216028675773 26.674650637990887 16.627328841758455 101.60780449157488 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0019254 7 carnitine metabolic process, CoA-linked 3 3 3 3 2 3 2 2 160 1 2384 0.99975 0.011561 0.011561 66.67 24158;25287 acadm;acadl ACADM_7957;ACADL_32776 22.600749999999998 22.600749999999998 11.7137 15.396613764234008 20.746578723069664 15.171677994098513 17.482705 17.482705 8.36151 12.899317674049664 15.929276129894639 12.710865979432569 32.1435 32.1435 18.9642 18.638344802583727 29.898936090580285 18.366049185741083 0.0 11.7137 0.0 11.7137 11.7137;33.4878 8.36151;26.6039 18.9642;45.3228 2 0 2 24158;25287 ACADM_7957;ACADL_32776 22.600749999999998 22.600749999999998 15.396613764234008 17.482705 17.482705 12.899317674049664 32.1435 32.1435 18.638344802583727 11.7137;33.4878 8.36151;26.6039 18.9642;45.3228 0 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.7875092536462354 3.5802873373031616 1.693061113357544 1.8872262239456177 0.13729546636666284 1.7901436686515808 1.2621319999999976 43.939368 -0.3948371999999978 35.3602472 6.312072000000008 57.974928 UP 1.0 0.0 0.0 GO:2000144 9 positive regulation of DNA-templated transcription, initiation 9 10 3 3 3 2 2 2 160 8 2377 0.97825 0.12934 0.12934 20.0 24516;24890 jun;esr1 JUN_8938;ESR1_33192 19.9148 19.9148 16.4324 4.924857309608077 18.69632323155699 4.613550503628356 14.415600000000001 14.415600000000001 10.5224 5.5058162410309315 13.053386080030343 5.157786245326748 35.9223 35.9223 31.9156 5.666329480360278 37.32422708135786 5.308153228488359 0.0 16.4324 0.0 16.4324 16.4324;23.3972 10.5224;18.3088 39.929;31.9156 0 2 0 2 24516;24890 JUN_8938;ESR1_33192 19.9148 19.9148 4.924857309608077 14.415600000000001 14.415600000000001 5.5058162410309315 35.9223 35.9223 5.666329480360278 16.4324;23.3972 10.5224;18.3088 39.929;31.9156 0 Exp 2,1(0.5);Poly 2,1(0.5) 2.195812257099418 4.415492057800293 1.9785058498382568 2.436986207962036 0.32419457027016113 2.2077460289001465 13.089296000000001 26.740304 6.784928 22.046272000000002 28.069167999999998 43.775432 DOWN 0.0 1.0 0.0 GO:1990830 7 cellular response to leukemia inhibitory factor 26 32 2 2 1 1 1 1 161 31 2354 0.3858 0.87952 0.71885 3.12 89783 laptm5 LAPTM5_32639 38.674 38.674 38.674 38.674 24.6273 24.6273 24.6273 24.6273 71.0786 71.0786 71.0786 71.0786 38.674 24.6273 71.0786 0 1 0 1 89783 LAPTM5_32639 38.674 38.674 24.6273 24.6273 71.0786 71.0786 38.674 24.6273 71.0786 0 Exp 2,1(1) 1.6914139986038208 1.6914139986038208 1.6914139986038208 1.6914139986038208 0.0 1.6914139986038208 38.674 38.674 24.6273 24.6273 71.0786 71.0786 DOWN 0.0 1.0 0.0 GO:0006637 7 acyl-CoA metabolic process 29 31 14 14 8 12 7 7 155 24 2361 0.9995 0.002649 0.002649 22.58 298490;100359982;192272;170570;50559;170465;296925 ppcs;mpc2;acot2;acot12;acot1;acaa2;aass PPCS_9540;MPC2_33219;ACOT2_7969;ACOT12_32718;ACOT1_7968;ACAA2_7955;AASS_7936 27.332335714285712 27.4644 8.54905 11.59863814005458 29.478230510746013 8.351289323372 21.971922857142857 21.7498 7.19676 8.817333042044163 23.846589042041 6.320800945016303 36.522171428571426 37.0295 10.4125 17.73193532422169 38.95643984712364 13.339814028084371 0.5 14.442174999999999 2.5 27.0258 20.3353;46.8463;8.54905;30.3423;31.2018;26.5872;27.4644 16.7643;35.8494;7.19676;24.0157;26.858;21.3695;21.7498 25.6711;69.127;10.4125;41.1025;37.2719;35.0407;37.0295 7 0 7 298490;100359982;192272;170570;50559;170465;296925 PPCS_9540;MPC2_33219;ACOT2_7969;ACOT12_32718;ACOT1_7968;ACAA2_7955;AASS_7936 27.332335714285712 27.4644 11.59863814005458 21.971922857142857 21.7498 8.817333042044163 36.522171428571426 37.0295 17.73193532422169 20.3353;46.8463;8.54905;30.3423;31.2018;26.5872;27.4644 16.7643;35.8494;7.19676;24.0157;26.858;21.3695;21.7498 25.6711;69.127;10.4125;41.1025;37.2719;35.0407;37.0295 0 0 Exp 2,5(0.72);Linear,2(0.29) 5.603517121375936 366.74449920654297 1.7093055248260498 344.14306640625 128.70122245627462 2.371572256088257 18.739944335914032 35.92472709265739 15.439951129440042 28.503894584845675 23.386169911675246 49.658172945467605 UP 1.0 0.0 0.0 GO:0097191 6 extrinsic apoptotic signaling pathway 41 42 4 4 4 4 4 4 158 38 2347 0.87537 0.27636 0.33819 9.52 25513;289388;294515;29496 pik3r1;g0s2;foxo3;erbb3 PIK3R1_32562;G0S2_32729;FOXO3_8662;ERBB3_8571 34.8271 32.5554 13.1992 22.69489591574869 42.21835993436541 22.874746075675176 23.186375 22.73075 5.6804 17.231216657832572 28.557799072554758 16.827049662585086 65.4952 57.62535 32.7581 36.78474163155152 78.79705185845758 38.93440303873565 1.5 32.5554 18.7324;46.3784;13.1992;60.9984 11.6701;33.7914;5.6804;41.6036 41.5978;73.6529;32.7581;113.972 2 2 2 289388;29496 G0S2_32729;ERBB3_8571 53.6884 53.6884 10.33790114094727 37.697500000000005 37.697500000000005 5.524059595985512 93.81245 93.81245 28.509909021338522 46.3784;60.9984 33.7914;41.6036 73.6529;113.972 2 25513;294515 PIK3R1_32562;FOXO3_8662 15.965799999999998 15.965799999999998 3.912563241661411 8.67525 8.67525 4.2353574872730615 37.177949999999996 37.177949999999996 6.250611813654778 18.7324;13.1992 11.6701;5.6804 41.5978;32.7581 0 Exp 4,1(0.25);Linear,2(0.5);Poly 2,1(0.25) 1.868035959983616 7.5484548807144165 1.6013026237487793 2.285230875015259 0.31412784510329383 1.8309606909751892 12.586102002566285 57.06809799743372 6.299782675324078 40.072967324675915 29.44615320107951 101.54424679892048 CONFLICT 0.5 0.5 0.0 GO:1902553 7 positive regulation of catalase activity 1 1 1 1 1 1 1 1 161 0 2385 1.0 0.063604 0.063604 100.0 293615 sirt3 SIRT3_9828 2.38018 2.38018 2.38018 2.38018 0.56209 0.56209 0.56209 0.56209 8.82917 8.82917 8.82917 8.82917 0.0 2.38018 0.0 2.38018 2.38018 0.56209 8.82917 1 0 1 293615 SIRT3_9828 2.38018 2.38018 0.56209 0.56209 8.82917 8.82917 2.38018 0.56209 8.82917 0 0 Hill,1(1) 1.5209722518920898 1.5209722518920898 1.5209722518920898 1.5209722518920898 0.0 1.5209722518920898 2.38018 2.38018 0.56209 0.56209 8.82917 8.82917 UP 1.0 0.0 0.0 GO:0001676 7 long-chain fatty acid metabolic process 44 52 21 21 15 18 12 12 150 40 2345 0.99999 6.4735E-5 6.4735E-5 23.08 65192;85255;81869;29328;65030;25315;65210;24894;29184;192272;50559;25287 slc27a2;hacl1;gstm7;gpx4;ephx2;ephx1;cyp2j4;cyp2a1;cd36;acot2;acot1;acadl SLC27A2_9860;HACL1_8775;GSTM7_8761;GPX4_32827;EPHX2_33282;EPHX1_8567;CYP2J4_32580;CYP2A1_32717;CD36_8243;ACOT2_7969;ACOT1_7968;ACADL_32776 29.94087 32.3448 7.62189 16.617157608934317 28.755521510234516 16.242212510534326 22.51066416666667 26.73095 5.49916 12.578542834678617 21.830214991542924 12.704391884981906 45.71588333333333 41.4881 10.4125 26.475216567603663 43.14795989478816 24.53878139966662 1.5 10.511875 4.5 24.52065 7.62189;17.6275;42.3152;45.9204;38.7293;12.4747;17.8395;55.3937;48.1296;8.54905;31.2018;33.4878 5.49916;11.195;31.4035;34.2198;29.2097;7.00435;14.6501;38.7444;37.5433;7.19676;26.858;26.6039 13.3925;37.6534;64.5991;70.4292;57.2113;23.684;22.6149;96.8569;69.1421;10.4125;37.2719;45.3228 12 0 12 65192;85255;81869;29328;65030;25315;65210;24894;29184;192272;50559;25287 SLC27A2_9860;HACL1_8775;GSTM7_8761;GPX4_32827;EPHX2_33282;EPHX1_8567;CYP2J4_32580;CYP2A1_32717;CD36_8243;ACOT2_7969;ACOT1_7968;ACADL_32776 29.94087 32.3448 16.617157608934317 22.51066416666667 26.73095 12.578542834678617 45.71588333333333 41.4881 26.475216567603663 7.62189;17.6275;42.3152;45.9204;38.7293;12.4747;17.8395;55.3937;48.1296;8.54905;31.2018;33.4878 5.49916;11.195;31.4035;34.2198;29.2097;7.00435;14.6501;38.7444;37.5433;7.19676;26.858;26.6039 13.3925;37.6534;64.5991;70.4292;57.2113;23.684;22.6149;96.8569;69.1421;10.4125;37.2719;45.3228 0 0 Exp 2,4(0.34);Hill,2(0.17);Linear,5(0.42);Poly 2,1(0.09) 3.9649119299348197 380.30635845661163 1.547789216041565 344.14306640625 98.43803286337929 2.315011143684387 20.538827989689025 39.342912010310975 15.393683576884026 29.627644756449303 30.73611938941692 60.695647277249755 UP 1.0 0.0 0.0 GO:0045597 6 positive regulation of cell differentiation 285 303 21 21 18 19 16 16 146 287 2098 0.24809 0.82736 0.45436 5.28 79426;24825;360268;29441;25513;81819;25591;24539;24516;24471;29455;294515;314322;25661;25695;29184 zfp36;tf;sult1e1;por;pik3r1;pax8;parp1;lpl;jun;hspb1;gdf15;foxo3;fos;fn1;cebpd;cd36 ZFP36_10204;TF_10003;SULT1E1_32446;POR_9531;PIK3R1_32562;PAX8_9432;PARP1_9425;LPL_32544;JUN_8938;HSPB1_8847;GDF15_33113;FOXO3_8662;FOS_8657;FN1_8655;CEBPD_8283;CD36_8243 38.55172937500008 36.064 1.28141E-12 32.72073651322471 47.557974913892274 31.246184101438825 27.01492163750008 24.9655 1.28141E-12 24.620983822940186 33.39709800272684 23.610247711071764 63.58615062500009 65.3381 1.28142E-12 45.679121385612866 76.83595940076304 44.250085179911494 14.5 97.12505 0.348134;45.1539;50.1846;12.4414;18.7324;56.8931;26.9741;74.2041;16.4324;89.1011;105.149;13.1992;1.28141E-12;59.5777;0.306936;48.1296 0.118102;28.132;36.5009;8.48981;11.6701;45.1162;21.799;49.8682;10.5224;60.3265;85.3487;5.6804;1.28141E-12;31.0499;0.0732342;37.5433 1.15962;61.5341;80.9788;79.2355;41.5978;81.5688;35.2797;155.425;39.929;106.138;125.652;32.7581;1.28142E-12;105.243;1.73689;69.1421 6 10 6 24825;360268;81819;25591;24539;29184 TF_10003;SULT1E1_32446;PAX8_9432;PARP1_9425;LPL_32544;CD36_8243 50.256566666666664 49.1571 15.428334680277928 36.49326666666666 37.0221 10.394024267369547 80.65474999999999 75.06045 40.36970723157405 45.1539;50.1846;56.8931;26.9741;74.2041;48.1296 28.132;36.5009;45.1162;21.799;49.8682;37.5433 61.5341;80.9788;81.5688;35.2797;155.425;69.1421 10 79426;29441;25513;24516;24471;29455;294515;314322;25661;25695 ZFP36_10204;POR_9531;PIK3R1_32562;JUN_8938;HSPB1_8847;GDF15_33113;FOXO3_8662;FOS_8657;FN1_8655;CEBPD_8283 31.528827000000128 14.8158 38.80764606885648 21.327914620000126 9.506105 29.231374561260566 53.34499100000013 40.763400000000004 47.55503202281139 0.348134;12.4414;18.7324;16.4324;89.1011;105.149;13.1992;1.28141E-12;59.5777;0.306936 0.118102;8.48981;11.6701;10.5224;60.3265;85.3487;5.6804;1.28141E-12;31.0499;0.0732342 1.15962;79.2355;41.5978;39.929;106.138;125.652;32.7581;1.28142E-12;105.243;1.73689 0 Exp 2,5(0.32);Exp 4,1(0.07);Hill,3(0.19);Poly 2,6(0.38);Power,1(0.07) 1.8276738667096404 29.487290263175964 1.559399127960205 2.6703107357025146 0.26277398684712666 1.7939516305923462 22.51856848351997 54.58489026648019 14.950639564259387 39.07920371074077 41.20338114604978 85.9689201039504 DOWN 0.375 0.625 0.0 GO:0035924 7 cellular response to vascular endothelial growth factor stimulus 17 17 2 2 2 2 2 2 160 15 2370 0.91096 0.295 0.295 11.76 24471;25661 hspb1;fn1 HSPB1_8847;FN1_8655 74.3394 74.3394 59.5777 20.876196343682977 71.70028517771317 20.539856856598863 45.6882 45.6882 31.0499 20.70168239008608 43.071146780988556 20.368154523120722 105.6905 105.6905 105.243 0.6328605691622222 105.61049540141221 0.6226644589309446 0.0 59.5777 0.5 74.3394 89.1011;59.5777 60.3265;31.0499 106.138;105.243 0 2 0 2 24471;25661 HSPB1_8847;FN1_8655 74.3394 74.3394 20.876196343682977 45.6882 45.6882 20.70168239008608 105.6905 105.6905 0.6328605691622222 89.1011;59.5777 60.3265;31.0499 106.138;105.243 0 Poly 2,1(0.5);Power,1(0.5) 1.7377929858237837 3.4765511751174927 1.6973176002502441 1.7792335748672485 0.05792334113918891 1.7382755875587463 45.406468 103.272332 16.997132 74.379268 104.81339999999999 106.56760000000001 DOWN 0.0 1.0 0.0 GO:0009314 4 response to radiation 159 166 18 18 15 17 14 14 148 152 2233 0.89885 0.16541 0.24948 8.43 29482;25513;25591;24516;24464;25675;25112;314322;361969;24330;25146;114851;246142;79431 slc1a2;pik3r1;parp1;jun;hp;hmgcr;gadd45a;fos;fga;egr1;cyp17a1;cdkn1a;bmf;bhlhe40 SLC1A2_33059;PIK3R1_32562;PARP1_9425;JUN_8938;HP_8823;HMGCR_8810;GADD45A_8678;FOS_8657;FGA_8632;EGR1_8533;CYP17A1_32365;CDKN1A_8271;BMF_8152;BHLHE40_8141 34.49272692857152 22.85325 1.28141E-12 34.36169590282319 41.87229250074815 37.80798168666296 25.512830428571515 16.73455 1.28141E-12 27.78984454889592 31.897475423704133 31.275886731389924 54.69191285714295 39.39005 1.28142E-12 46.54187072130439 61.23895971875638 47.760454023910384 7.5 27.7772 13.3235;18.7324;26.9741;16.4324;64.9285;1.63089;102.919;1.28141E-12;28.5803;0.750017;49.6922;6.24967;94.8767;57.8085 9.10952;11.6701;21.799;10.5224;41.6103;0.663137;89.5012;1.28141E-12;22.529;0.186019;35.6654;2.44025;73.1342;38.3491 24.6773;41.5978;35.2797;39.929;136.455;7.6286;115.437;1.28142E-12;38.8511;4.70178;81.6409;19.0606;109.848;110.58 3 11 3 25591;25146;246142 PARP1_9425;CYP17A1_32365;BMF_8152 57.181000000000004 49.6922 34.56519008728289 43.53286666666667 35.6654 26.556514522303807 75.58953333333334 81.6409 37.65065896001465 26.9741;49.6922;94.8767 21.799;35.6654;73.1342 35.2797;81.6409;109.848 11 29482;25513;24516;24464;25675;25112;314322;361969;24330;114851;79431 SLC1A2_33059;PIK3R1_32562;JUN_8938;HP_8823;HMGCR_8810;GADD45A_8678;FOS_8657;FGA_8632;EGR1_8533;CDKN1A_8271;BHLHE40_8141 28.305016090909206 16.4324 33.157950077150986 20.598275090909205 10.5224 27.18315202404525 48.99256181818193 38.8511 48.63878082686309 13.3235;18.7324;16.4324;64.9285;1.63089;102.919;1.28141E-12;28.5803;0.750017;6.24967;57.8085 9.10952;11.6701;10.5224;41.6103;0.663137;89.5012;1.28141E-12;22.529;0.186019;2.44025;38.3491 24.6773;41.5978;39.929;136.455;7.6286;115.437;1.28142E-12;38.8511;4.70178;19.0606;110.58 0 Exp 2,3(0.22);Exp 4,2(0.15);Hill,2(0.15);Linear,2(0.15);Poly 2,5(0.36) 1.840520277456208 26.743687629699707 1.522104263305664 4.21828556060791 0.6798133387401389 1.7024496793746948 16.49296986700856 52.49248399013448 10.955619629856889 40.070041227286154 30.31179004413245 79.07203567015345 DOWN 0.21428571428571427 0.7857142857142857 0.0 GO:0051234 3 establishment of localization 596 632 56 54 41 50 36 36 126 596 1789 0.2458 0.81059 0.45378 5.7 257644;79426;24856;171139;24825;170698;29573;25351;65192;361074;29482;29500;297784;308821;298199;25513;25493;100359982;81678;192235;63868;24471;85255;24384;24360;304929;25428;83842;170945;81718;114851;29184;65054;312382;140668;25303 zwint;zfp36;ttr;timm9;tf;slco1a2;slc37a4;slc2a2;slc27a2;slc25a30;slc1a2;slc10a2;rrs1;rab30;plin2;pik3r1;nfkbia;mpc2;itpr2;hyou1;hspd1;hspb1;hacl1;gc;fabp1;f5;cyp7a1;crot;chrna2;cdo1;cdkn1a;cd36;aqp9;abcg2;abcc3;abcc2 ZWINT_10214;ZFP36_10204;TTR_10102;TIMM9_10020;TF_10003;SLCO1A2_9886;SLC37A4_9871;SLC2A2_9863;SLC27A2_9860;SLC25A30_9856;SLC1A2_33059;SLC10A2_9833;RRS1_9755;RAB30_9639;PLIN2_9502;PIK3R1_32562;NFKBIA_9307;MPC2_33219;ITPR2_8931;HYOU1_8857;HSPD1_8849;HSPB1_8847;HACL1_8775;GC_32893;FABP1_33091;F5_33079;CYP7A1_8430;CROT_8384;CHRNA2_32401;CDO1_8275;CDKN1A_8271;CD36_8243;AQP9_32709;ABCG2_32656;ABCC3_7941;ABCC2_32541 171139(0.04986) 34.16721291666667 35.782650000000004 0.348134 23.283424588377844 35.12964920582461 21.09928782861256 24.183126305555557 24.34055 0.118102 17.360661922141535 24.662045836770467 15.332908544434156 53.696008611111104 47.9293 1.15962 32.895596017648614 54.94201011663597 30.75484388026603 30.5 52.50665 52.0003;0.348134;46.6406;38.5191;45.1539;104.197;39.7166;29.7555;7.62189;53.013;13.3235;56.585;60.39;26.4203;25.6517;18.7324;0.520151;46.8463;31.8111;40.1982;42.2579;89.1011;17.6275;42.356;33.8478;10.6089;5.72128;7.4229;49.3913;22.9638;6.24967;48.1296;27.7316;5.21654;37.7175;46.2316 38.9015;0.118102;28.5876;29.55;28.132;80.3101;22.6911;23.3399;5.49916;37.4804;9.10952;35.2796;43.109;21.0125;20.9252;11.6701;0.160202;35.8494;24.7342;29.3844;23.9469;60.3265;11.195;26.3722;26.4736;2.59129;0.985273;5.75707;41.8524;18.5144;2.44025;37.5433;21.9372;2.73368;30.9007;31.1788 80.8613;1.15962;63.7146;55.4685;61.5341;128.412;60.0334;40.808;13.3925;90.2594;24.6773;116.8;104.942;35.3561;33.0375;41.5978;2.88499;69.127;44.3296;62.3571;102.383;106.138;37.6534;78.7583;46.9257;37.5078;22.3625;10.316;62.472;30.0179;19.0606;69.1421;37.4625;11.386;48.9329;81.7848 18 18 18 257644;24856;171139;24825;65192;361074;297784;308821;298199;100359982;63868;85255;24360;83842;170945;29184;312382;140668 ZWINT_10214;TTR_10102;TIMM9_10020;TF_10003;SLC27A2_9860;SLC25A30_9856;RRS1_9755;RAB30_9639;PLIN2_9502;MPC2_33219;HSPD1_8849;HACL1_8775;FABP1_33091;CROT_8384;CHRNA2_32401;CD36_8243;ABCG2_32656;ABCC3_7941 35.77045166666667 40.3885 17.045911783494745 26.080522777777777 28.3598 12.755403816891658 55.38356111111111 58.5013 28.824176764513634 52.0003;46.6406;38.5191;45.1539;7.62189;53.013;60.39;26.4203;25.6517;46.8463;42.2579;17.6275;33.8478;7.4229;49.3913;48.1296;5.21654;37.7175 38.9015;28.5876;29.55;28.132;5.49916;37.4804;43.109;21.0125;20.9252;35.8494;23.9469;11.195;26.4736;5.75707;41.8524;37.5433;2.73368;30.9007 80.8613;63.7146;55.4685;61.5341;13.3925;90.2594;104.942;35.3561;33.0375;69.127;102.383;37.6534;46.9257;10.316;62.472;69.1421;11.386;48.9329 18 79426;170698;29573;25351;29482;29500;25513;25493;81678;192235;24471;24384;304929;25428;81718;114851;65054;25303 ZFP36_10204;SLCO1A2_9886;SLC37A4_9871;SLC2A2_9863;SLC1A2_33059;SLC10A2_9833;PIK3R1_32562;NFKBIA_9307;ITPR2_8931;HYOU1_8857;HSPB1_8847;GC_32893;F5_33079;CYP7A1_8430;CDO1_8275;CDKN1A_8271;AQP9_32709;ABCC2_32541 32.56397416666667 28.74355 28.637715560644075 22.285729833333335 22.314149999999998 21.217682346483773 52.008456111111116 41.2029 37.29652442334495 0.348134;104.197;39.7166;29.7555;13.3235;56.585;18.7324;0.520151;31.8111;40.1982;89.1011;42.356;10.6089;5.72128;22.9638;6.24967;27.7316;46.2316 0.118102;80.3101;22.6911;23.3399;9.10952;35.2796;11.6701;0.160202;24.7342;29.3844;60.3265;26.3722;2.59129;0.985273;18.5144;2.44025;21.9372;31.1788 1.15962;128.412;60.0334;40.808;24.6773;116.8;41.5978;2.88499;44.3296;62.3571;106.138;78.7583;37.5078;22.3625;30.0179;19.0606;37.4625;81.7848 0 Exp 2,12(0.34);Exp 3,2(0.06);Exp 4,3(0.09);Hill,4(0.12);Linear,6(0.17);Poly 2,9(0.25) 2.034472856434099 77.62137842178345 1.5074360370635986 5.963563919067383 0.9161673253816035 1.8567861318588257 26.56129421779656 41.77313161553676 18.511976744322656 29.85427586678846 42.95011391201256 64.44190331020964 CONFLICT 0.5 0.5 0.0 GO:0009890 6 negative regulation of biosynthetic process 293 306 27 27 22 24 20 20 142 286 2099 0.61203 0.48523 0.90052 6.54 79426;24522;246273;25106;25591;24516;63868;25112;294515;25661;24890;116636;24330;25428;65210;25695;114851;29184;79431;25287 zfp36;zfp354a;trib3;rgn;parp1;jun;hspd1;gadd45a;foxo3;fn1;esr1;eif4ebp1;egr1;cyp7a1;cyp2j4;cebpd;cdkn1a;cd36;bhlhe40;acadl ZFP36_10204;ZFP354A_10203;TRIB3_10079;RGN_9699;PARP1_9425;JUN_8938;HSPD1_8849;GADD45A_8678;FOXO3_8662;FN1_8655;ESR1_33192;EIF4EBP1_8550;EGR1_8533;CYP7A1_8430;CYP2J4_32580;CEBPD_8283;CDKN1A_8271;CD36_8243;BHLHE40_8141;ACADL_32776 36.281928199999996 25.185650000000003 0.306936 34.94703148308012 39.0490180061673 36.02273256640849 25.35520641 20.0539 0.0732342 26.894880049990576 27.420913278747694 28.070119539256666 55.15889300000001 37.60435 1.15962 45.648394011607785 57.455511863051406 46.36308239872895 14.5 58.6931 0.348134;0.834827;108.064;77.4407;26.9741;16.4324;42.2579;102.919;13.1992;59.5777;23.3972;83.9001;0.750017;5.72128;17.8395;0.306936;6.24967;48.1296;57.8085;33.4878 0.118102;0.27095;83.8836;58.7732;21.799;10.5224;23.9469;89.5012;5.6804;31.0499;18.3088;42.4185;0.186019;0.985273;14.6501;0.0732342;2.44025;37.5433;38.3491;26.6039 1.15962;2.99857;143.428;89.8047;35.2797;39.929;102.383;115.437;32.7581;105.243;31.9156;107.32;4.70178;22.3625;22.6149;1.73689;19.0606;69.1421;110.58;45.3228 7 13 7 25106;25591;63868;116636;65210;29184;25287 RGN_9699;PARP1_9425;HSPD1_8849;EIF4EBP1_8550;CYP2J4_32580;CD36_8243;ACADL_32776 47.14710000000001 42.2579 24.986051495784594 32.24784285714286 26.6039 15.026073553644137 67.4096 69.1421 33.781758273561394 77.4407;26.9741;42.2579;83.9001;17.8395;48.1296;33.4878 58.7732;21.799;23.9469;42.4185;14.6501;37.5433;26.6039 89.8047;35.2797;102.383;107.32;22.6149;69.1421;45.3228 13 79426;24522;246273;24516;25112;294515;25661;24890;24330;25428;25695;114851;79431 ZFP36_10204;ZFP354A_10203;TRIB3_10079;JUN_8938;GADD45A_8678;FOXO3_8662;FN1_8655;ESR1_33192;EGR1_8533;CYP7A1_8430;CEBPD_8283;CDKN1A_8271;BHLHE40_8141 30.43145107692308 13.1992 38.93098571288733 21.643786784615386 5.6804 31.460332487800876 48.56235846153846 31.9156 50.931534314622944 0.348134;0.834827;108.064;16.4324;102.919;13.1992;59.5777;23.3972;0.750017;5.72128;0.306936;6.24967;57.8085 0.118102;0.27095;83.8836;10.5224;89.5012;5.6804;31.0499;18.3088;0.186019;0.985273;0.0732342;2.44025;38.3491 1.15962;2.99857;143.428;39.929;115.437;32.7581;105.243;31.9156;4.70178;22.3625;1.73689;19.0606;110.58 0 Exp 2,5(0.25);Exp 3,2(0.1);Exp 4,2(0.1);Hill,5(0.25);Linear,1(0.05);Poly 2,4(0.2);Power,1(0.05) 2.2206247041704663 47.67491972446442 1.522104263305664 4.591650485992432 1.0288424221588386 1.9127013683319092 20.965716350433485 51.598140049566524 13.568005522457556 37.14240729754245 35.15260223356472 75.16518376643526 DOWN 0.35 0.65 0.0 GO:0010667 11 negative regulation of cardiac muscle cell apoptotic process 9 11 2 2 2 2 2 2 160 9 2376 0.97146 0.15174 0.15174 18.18 81819;50559 pax8;acot1 PAX8_9432;ACOT1_7968 44.04745 44.04745 31.2018 18.16649244749794 43.2307506403324 18.12973943984957 35.9871 35.9871 26.858 12.910497032260237 35.40669105811372 12.884377537947158 59.42035 59.42035 37.2719 31.322638375542375 58.01219821845296 31.259268896205022 0.0 31.2018 0.5 44.04745 56.8931;31.2018 45.1162;26.858 81.5688;37.2719 2 0 2 81819;50559 PAX8_9432;ACOT1_7968 44.04745 44.04745 18.16649244749794 35.9871 35.9871 12.910497032260237 59.42035 59.42035 31.322638375542375 56.8931;31.2018 45.1162;26.858 81.5688;37.2719 0 0 Exp 2,2(1) 24.556196490725853 345.89526438713074 1.7521979808807373 344.14306640625 242.10690487992957 172.94763219356537 18.869976 69.22492399999999 18.094064000000003 53.88013599999999 16.00938800000001 102.831312 UP 1.0 0.0 0.0 GO:0008210 6 estrogen metabolic process 11 12 2 2 2 2 2 2 160 10 2375 0.96369 0.17482 0.17482 16.67 360268;29540 sult1e1;hsd17b7 SULT1E1_32446;HSD17B7_8834 25.581047 25.581047 0.977494 34.79467833516525 30.4175857922889 34.11576505765315 18.411791 18.411791 0.322682 25.581863279045216 21.967727713548737 25.082710320183402 43.236760000000004 43.236760000000004 5.49472 53.37530483962785 50.65604779799079 52.33384663737578 0.0 0.977494 0.5 25.581047 50.1846;0.977494 36.5009;0.322682 80.9788;5.49472 1 1 1 360268 SULT1E1_32446 50.1846 50.1846 36.5009 36.5009 80.9788 80.9788 50.1846 36.5009 80.9788 1 29540 HSD17B7_8834 0.977494 0.977494 0.322682 0.322682 5.49472 5.49472 0.977494 0.322682 5.49472 0 Exp 2,1(0.5);Exp 4,1(0.5) 1.7324989921713512 3.4650317430496216 1.7248681783676147 1.7401635646820068 0.01081547138377456 1.7325158715248108 -22.64191688 73.80401088 -17.042862639999996 53.86644464 -30.737638399999994 117.2111584 CONFLICT 0.5 0.5 0.0 GO:0042730 7 fibrinolysis 12 12 3 3 3 3 3 3 159 9 2376 0.99478 0.036309 0.036309 25.0 85253;361969;113936 plg;fga;cpb2 PLG_9501;FGA_8632;CPB2_8369 41.732533333333336 28.5803 25.8316 25.198287797851137 46.54176452478774 25.80084416759462 29.733999999999998 22.529 20.4374 14.329019490530408 32.58094981101068 14.537599956199557 74.74476666666668 38.8511 34.8042 65.70553674419936 86.61722178581212 68.04558043821758 0.0 25.8316 0.5 27.20595 70.7857;28.5803;25.8316 46.2356;22.529;20.4374 150.579;38.8511;34.8042 0 3 0 3 85253;361969;113936 PLG_9501;FGA_8632;CPB2_8369 41.732533333333336 28.5803 25.198287797851137 29.733999999999998 22.529 14.329019490530408 74.74476666666668 38.8511 65.70553674419936 70.7857;28.5803;25.8316 46.2356;22.529;20.4374 150.579;38.8511;34.8042 0 Exp 2,1(0.34);Linear,2(0.67) 1.5434067656028816 4.630450487136841 1.5254690647125244 1.5630855560302734 0.01885843391969935 1.541895866394043 13.217986376647584 70.24708029001908 13.51918801024101 45.948811989758994 0.39195238670242816 149.0975809466309 DOWN 0.0 1.0 0.0 GO:0002682 4 regulation of immune system process 334 363 25 24 16 20 13 13 149 350 2035 0.0094168 0.99559 0.019532 3.58 79426;25513;25493;24516;65164;63868;294515;314322;246186;25423;114851;29184;313421 zfp36;pik3r1;nfkbia;jun;htra1;hspd1;foxo3;fos;fgl1;ctsc;cdkn1a;cd36;c8b ZFP36_10204;PIK3R1_32562;NFKBIA_9307;JUN_8938;HTRA1_8856;HSPD1_8849;FOXO3_8662;FOS_8657;FGL1_8640;CTSC_32456;CDKN1A_8271;CD36_8243;C8B_8181 20.92906576923087 16.4324 1.28141E-12 18.705618584437335 26.72374271495283 19.155839050129806 14.106681076923175 10.5224 1.28141E-12 13.54671436153867 18.398747734031087 14.181981458828636 39.75329307692318 32.7581 1.28142E-12 34.10393689036964 48.98940339732286 33.86574814056514 0.348134;18.7324;0.520151;16.4324;33.1323;42.2579;13.1992;1.28141E-12;15.4757;56.2386;6.24967;48.1296;21.3618 0.118102;11.6701;0.160202;10.5224;25.6145;23.9469;5.6804;1.28141E-12;10.2138;38.2681;2.44025;37.5433;17.2088 1.15962;41.5978;2.88499;39.929;46.6629;102.383;32.7581;1.28142E-12;30.4106;102.888;19.0606;69.1421;27.9161 2 11 2 63868;29184 HSPD1_8849;CD36_8243 45.19375 45.19375 4.151918887092963 30.7451 30.7451 9.61410663972478 85.76255 85.76255 23.504865802743858 42.2579;48.1296 23.9469;37.5433 102.383;69.1421 11 79426;25513;25493;24516;65164;294515;314322;246186;25423;114851;313421 ZFP36_10204;PIK3R1_32562;NFKBIA_9307;JUN_8938;HTRA1_8856;FOXO3_8662;FOS_8657;FGL1_8640;CTSC_32456;CDKN1A_8271;C8B_8181 16.517305000000118 15.4757 16.703035064024558 11.081514000000118 10.2138 12.063948900097028 31.387973636363757 30.4106 28.9844712090229 0.348134;18.7324;0.520151;16.4324;33.1323;13.1992;1.28141E-12;15.4757;56.2386;6.24967;21.3618 0.118102;11.6701;0.160202;10.5224;25.6145;5.6804;1.28141E-12;10.2138;38.2681;2.44025;17.2088 1.15962;41.5978;2.88499;39.929;46.6629;32.7581;1.28142E-12;30.4106;102.888;19.0606;27.9161 0 Exp 2,3(0.24);Exp 3,1(0.08);Exp 4,3(0.24);Hill,2(0.16);Linear,1(0.08);Poly 2,3(0.24) 1.8141506201163045 23.93166446685791 1.511321783065796 2.6703107357025146 0.34237605339569144 1.8546061515808105 10.760575675915215 31.09755586254652 6.742603264661598 21.47075888918475 21.214181801485125 58.29240435236122 DOWN 0.15384615384615385 0.8461538461538461 0.0 GO:0008299 5 isoprenoid biosynthetic process 14 14 8 8 4 5 2 2 160 12 2373 0.94527 0.22236 0.22236 14.29 25675;298541 hmgcr;dhdds HMGCR_8810;DHDDS_8467 24.787345000000002 24.787345000000002 1.63089 32.74817271748227 33.69562058469946 30.227935234616083 18.6159685 18.6159685 0.663137 25.389137790298918 25.522412967759564 23.43523772788088 39.501400000000004 39.501400000000004 7.6286 45.07494603080519 51.76284874316941 41.6060633696251 0.0 1.63089 0.5 24.787345000000002 1.63089;47.9438 0.663137;36.5688 7.6286;71.3742 1 1 1 298541 DHDDS_8467 47.9438 47.9438 36.5688 36.5688 71.3742 71.3742 47.9438 36.5688 71.3742 1 25675 HMGCR_8810 1.63089 1.63089 0.663137 0.663137 7.6286 7.6286 1.63089 0.663137 7.6286 0 Exp 2,1(0.5);Exp 4,1(0.5) 1.824954981768193 3.6530126333236694 1.7512425184249878 1.9017701148986816 0.10643908422226116 1.8265063166618347 -20.599306799999994 70.1739968 -16.57158124 53.80351824 -22.96928799999999 101.972088 CONFLICT 0.5 0.5 0.0 GO:0010812 7 negative regulation of cell-substrate adhesion 18 19 2 2 2 2 2 2 160 17 2368 0.88421 0.34304 0.34304 10.53 85253;25513 plg;pik3r1 PLG_9501;PIK3R1_32562 44.75905 44.75905 18.7324 36.80724141313772 55.53686371498064 33.502992157348416 28.952849999999998 28.952849999999998 11.6701 24.441499445103606 36.109754940996304 22.24734407645295 96.08840000000001 96.08840000000001 41.5978 77.06134554184737 118.65333002432213 70.14341624639401 0.0 18.7324 0.5 44.75905 70.7857;18.7324 46.2356;11.6701 150.579;41.5978 0 2 0 2 85253;25513 PLG_9501;PIK3R1_32562 44.75905 44.75905 36.80724141313772 28.952849999999998 28.952849999999998 24.441499445103606 96.08840000000001 96.08840000000001 77.06134554184737 70.7857;18.7324 46.2356;11.6701 150.579;41.5978 0 Linear,1(0.5);Poly 2,1(0.5) 1.597809310997291 3.1990491151809692 1.5254690647125244 1.6735800504684448 0.10473028239623547 1.5995245575904846 -6.2531840000000045 95.77128400000001 -4.921340000000001 62.82704 -10.713175999999976 202.889976 DOWN 0.0 1.0 0.0 GO:0010822 8 positive regulation of mitochondrion organization 24 25 2 2 2 2 2 2 160 23 2362 0.79018 0.47902 0.67089 8.0 83516;246142 ppargc1a;bmf PPARGC1A_33189;BMF_8152 68.64305 68.64305 42.4094 37.099983620548926 75.678801551107 35.74080559902351 49.7165 49.7165 26.2988 33.11762893958443 55.99702593132707 31.90434664167027 95.78925000000001 95.78925000000001 81.7305 19.882074920012737 99.55974598965929 19.153684322054747 0.5 68.64305 42.4094;94.8767 26.2988;73.1342 81.7305;109.848 1 1 1 246142 BMF_8152 94.8767 94.8767 73.1342 73.1342 109.848 109.848 94.8767 73.1342 109.848 1 83516 PPARGC1A_33189 42.4094 42.4094 26.2988 26.2988 81.7305 81.7305 42.4094 26.2988 81.7305 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.729170093198975 3.458800792694092 1.701177716255188 1.7576230764389038 0.0399128969524226 1.729400396347046 17.225096 120.061004 3.8178079999999994 95.61519200000001 68.23410000000001 123.34440000000001 CONFLICT 0.5 0.5 0.0 GO:0044272 5 sulfur compound biosynthetic process 25 31 6 6 5 5 4 4 158 27 2358 0.95673 0.13045 0.13045 12.9 298490;294103;100359982;81718 ppcs;papss2;mpc2;cdo1 PPCS_9540;PAPSS2_33237;MPC2_33219;CDO1_8275 31.147425 28.70405 20.3353 12.127074752903123 29.787957917782812 12.120716997202893 24.211775000000003 22.1167 16.7643 8.672389301830263 23.329595183391717 8.68504361056437 43.97935 40.55965 25.6711 20.11004724749961 41.534582598392745 20.060189366172338 0.5 21.649549999999998 2.5 40.6453 20.3353;34.4443;46.8463;22.9638 16.7643;25.719;35.8494;18.5144 25.6711;51.1014;69.127;30.0179 2 2 2 298490;100359982 PPCS_9540;MPC2_33219 33.5908 33.5908 18.746107876036557 26.30685 26.30685 13.495203629623386 47.399049999999995 47.399049999999995 30.7279615725645 20.3353;46.8463 16.7643;35.8494 25.6711;69.127 2 294103;81718 PAPSS2_33237;CDO1_8275 28.70405 28.70405 8.117939401412174 22.1167 22.1167 5.094421515736588 40.55965 40.55965 14.908285821146572 34.4443;22.9638 25.719;18.5144 51.1014;30.0179 0 Exp 2,3(0.75);Linear,1(0.25) 2.0166429712025855 8.10871148109436 1.8057876825332642 2.371572256088257 0.24422342177452525 1.9656757712364197 19.262891742154956 43.03195825784505 15.712833484206339 32.71071651579366 24.27150369745038 63.68719630254961 CONFLICT 0.5 0.5 0.0 GO:0071277 7 cellular response to calcium ion 24 25 2 2 2 2 2 2 160 23 2362 0.79018 0.47902 0.67089 8.0 24516;314322 jun;fos JUN_8938;FOS_8657 8.216200000000642 8.216200000000642 1.28141E-12 11.619461471168918 9.77484733411384 11.408467112443399 5.26120000000064 5.26120000000064 1.28141E-12 7.440460394356422 6.259271536019238 7.305351278204592 19.96450000000064 19.96450000000064 1.28142E-12 28.23406666599675 23.751848738091777 27.721372613420638 0.5 8.216200000000642 16.4324;1.28141E-12 10.5224;1.28141E-12 39.929;1.28142E-12 0 2 0 2 24516;314322 JUN_8938;FOS_8657 8.216200000000642 8.216200000000642 11.619461471168918 5.26120000000064 5.26120000000064 7.440460394356422 19.96450000000064 19.96450000000064 28.23406666599675 16.4324;1.28141E-12 10.5224;1.28141E-12 39.929;1.28142E-12 0 Hill,1(0.5);Poly 2,1(0.5) 1.9371549035745876 3.875174045562744 1.8966681957244873 1.9785058498382568 0.05786796018024559 1.937587022781372 -7.887551999998097 24.319951999999383 -5.050751999998102 15.573151999999382 -19.165919999998103 59.094919999999384 DOWN 0.0 1.0 0.0 GO:0009888 4 tissue development 153 164 14 14 11 11 9 9 153 155 2230 0.39405 0.73006 0.74229 5.49 83516;85253;81819;25685;246186;24890;29496;114851;65183 ppargc1a;plg;pax8;igfbp1;fgl1;esr1;erbb3;cdkn1a;aldh3a2 PPARGC1A_33189;PLG_9501;PAX8_9432;IGFBP1_32306;FGL1_8640;ESR1_33192;ERBB3_8571;CDKN1A_8271;ALDH3A2_8024 40.92699666666667 43.1079 6.24967 21.735469871556717 39.63297847795112 24.27103439675845 28.309194444444444 31.8774 2.44025 15.464380398807702 27.394894031844405 17.603052551117433 73.85613333333335 81.5688 19.0606 42.65784123865738 72.64552356985111 46.16054587714659 7.5 65.89205 42.4094;70.7857;56.8931;49.0259;15.4757;23.3972;60.9984;6.24967;43.1079 26.2988;46.2356;45.1162;32.6883;10.2138;18.3088;41.6036;2.44025;31.8774 81.7305;150.579;81.5688;89.1623;30.4106;31.9156;113.972;19.0606;66.3058 3 6 3 81819;29496;65183 PAX8_9432;ERBB3_8571;ALDH3A2_8024 53.66646666666667 56.8931 9.371545740342576 39.532399999999996 41.6036 6.858123536361866 87.28219999999999 81.5688 24.341299478047638 56.8931;60.9984;43.1079 45.1162;41.6036;31.8774 81.5688;113.972;66.3058 6 83516;85253;25685;246186;24890;114851 PPARGC1A_33189;PLG_9501;IGFBP1_32306;FGL1_8640;ESR1_33192;CDKN1A_8271 34.55726166666667 32.9033 23.97277636698796 22.697591666666668 22.303800000000003 15.825847394892216 67.1431 56.82305 50.12258360252392 42.4094;70.7857;49.0259;15.4757;23.3972;6.24967 26.2988;46.2356;32.6883;10.2138;18.3088;2.44025 81.7305;150.579;89.1623;30.4106;31.9156;19.0606 0 Exp 2,4(0.45);Exp 4,1(0.12);Linear,3(0.34);Poly 2,1(0.12) 1.8498766239645978 17.583638787269592 1.511321783065796 3.9562058448791504 0.8062186517914788 1.6013026237487793 26.726489683916277 55.12750364941706 18.205799250556748 38.412589638332136 45.98634372407716 101.7259229425895 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0010893 8 positive regulation of steroid biosynthetic process 18 20 4 4 4 4 4 4 158 16 2369 0.99306 0.034293 0.034293 20.0 83516;29441;25428;25146 ppargc1a;por;cyp7a1;cyp17a1 PPARGC1A_33189;POR_9531;CYP7A1_8430;CYP17A1_32365 27.56607 27.4254 5.72128 21.724337865005992 29.314931302946295 19.541975888404703 17.859820749999997 17.394305 0.985273 15.924849412496885 19.178670511830312 13.401329930095507 66.24235 80.4382 22.3625 29.276050026543317 76.65643977177487 17.059467329914575 0.0 5.72128 1.0 12.4414 42.4094;12.4414;5.72128;49.6922 26.2988;8.48981;0.985273;35.6654 81.7305;79.2355;22.3625;81.6409 1 3 1 25146 CYP17A1_32365 49.6922 49.6922 35.6654 35.6654 81.6409 81.6409 49.6922 35.6654 81.6409 3 83516;29441;25428 PPARGC1A_33189;POR_9531;CYP7A1_8430 20.190693333333332 12.4414 19.53313076949349 11.924627666666666 8.48981 13.001620729638532 61.109500000000004 79.2355 33.57906733368275 42.4094;12.4414;5.72128 26.2988;8.48981;0.985273 81.7305;79.2355;22.3625 0 Exp 2,1(0.25);Hill,1(0.25);Linear,1(0.25);Poly 2,1(0.25) 2.3468048701477136 10.209285378456116 1.7576230764389038 4.560328960418701 1.341930138898984 1.9456666707992554 6.276218892294125 48.855921107705875 2.253468325753053 33.46617317424694 37.55182097398755 94.93287902601244 DOWN 0.25 0.75 0.0 GO:0008206 7 bile acid metabolic process 10 11 5 5 5 4 4 4 158 7 2378 0.99967 0.0036576 0.0036576 36.36 65192;29500;25428;25284 slc27a2;slc10a2;cyp7a1;amacr SLC27A2_9860;SLC10A2_9833;CYP7A1_8430;AMACR_8038 17.991477500000002 6.671585 2.03774 25.833233187673038 17.527131959108235 24.2051214739016 10.732258250000001 3.33208 0.985273 16.497408444675553 11.174112091890956 15.007708121693355 39.072852499999996 17.8775 3.73641 52.37330748972889 35.43601233625967 50.44568286832891 0.0 2.03774 0.5 3.87951 7.62189;56.585;5.72128;2.03774 5.49916;35.2796;0.985273;1.165 13.3925;116.8;22.3625;3.73641 2 2 2 65192;25284 SLC27A2_9860;AMACR_8038 4.829815 4.829815 3.9485903321628593 3.33208 3.33208 3.0647139267474865 8.564455 8.564455 6.82788671874761 7.62189;2.03774 5.49916;1.165 13.3925;3.73641 2 29500;25428 SLC10A2_9833;CYP7A1_8430 31.15314 31.15314 35.966081328373825 18.1324365 18.1324365 24.24975117792891 69.58125 69.58125 66.77739664830459 56.585;5.72128 35.2796;0.985273 116.8;22.3625 0 Exp 2,1(0.25);Exp 4,1(0.25);Hill,2(0.5) 2.2329136462439054 9.904446005821228 1.5621941089630127 4.560328960418701 1.4185187215364952 1.890961468219757 -7.325091023919576 43.30804602391958 -5.43520202578204 26.899718525782042 -12.252988839934304 90.3986938399343 CONFLICT 0.5 0.5 0.0 GO:0071347 7 cellular response to interleukin-1 47 50 4 4 3 3 2 2 160 48 2337 0.37348 0.83832 0.76808 4.0 25661;25303 fn1;abcc2 FN1_8655;ABCC2_32541 52.904650000000004 52.904650000000004 46.2316 9.43711781239374 55.904479336008755 8.42978294587964 31.11435 31.11435 31.0499 0.09114606409384816 31.08537689164539 0.08141696987707955 93.5139 93.5139 81.7848 16.58745229443016 98.7866460853703 14.816877911976814 59.5777;46.2316 31.0499;31.1788 105.243;81.7848 0 2 0 2 25661;25303 FN1_8655;ABCC2_32541 52.904650000000004 52.904650000000004 9.43711781239374 31.11435 31.11435 0.09114606409384816 93.5139 93.5139 16.58745229443016 59.5777;46.2316 31.0499;31.1788 105.243;81.7848 0 Exp 2,1(0.5);Power,1(0.5) 1.8186629487770134 3.6381996870040894 1.7792335748672485 1.8589661121368408 0.05637941778453784 1.8190998435020447 39.825472000000005 65.983828 30.988028000000003 31.240672 70.52486400000002 116.50293599999999 DOWN 0.0 1.0 0.0 GO:0006955 3 immune response 185 212 12 12 8 11 7 7 155 205 2180 0.031651 0.98644 0.056079 3.3 24516;63868;246186;361969;25423;29184;313421 jun;hspd1;fgl1;fga;ctsc;cd36;c8b JUN_8938;HSPD1_8849;FGL1_8640;FGA_8632;CTSC_32456;CD36_8243;C8B_8181 32.63947142857143 28.5803 15.4757 16.280377146298374 34.102329339634174 16.444324974649632 22.890328571428572 22.529 10.2138 11.53525124704186 24.138513899865565 11.870318490817333 58.788557142857144 39.929 27.9161 32.82284344938532 59.881904642115124 32.32262188418283 16.4324;42.2579;15.4757;28.5803;56.2386;48.1296;21.3618 10.5224;23.9469;10.2138;22.529;38.2681;37.5433;17.2088 39.929;102.383;30.4106;38.8511;102.888;69.1421;27.9161 2 5 2 63868;29184 HSPD1_8849;CD36_8243 45.19375 45.19375 4.151918887092963 30.7451 30.7451 9.61410663972478 85.76255 85.76255 23.504865802743858 42.2579;48.1296 23.9469;37.5433 102.383;69.1421 5 24516;246186;361969;25423;313421 JUN_8938;FGL1_8640;FGA_8632;CTSC_32456;C8B_8181 27.617759999999997 21.3618 16.820804829525844 19.74842 17.2088 11.54543487452941 47.998960000000004 38.8511 31.12188129906352 16.4324;15.4757;28.5803;56.2386;21.3618 10.5224;10.2138;22.529;38.2681;17.2088 39.929;30.4106;38.8511;102.888;27.9161 0 Exp 2,3(0.43);Exp 3,1(0.15);Linear,1(0.15);Poly 2,2(0.29) 1.8193293862792106 13.03977370262146 1.511321783065796 2.6703107357025146 0.456405877735395 1.5736411809921265 20.578799258326853 44.700143598816 14.344894860538835 31.4357622823183 34.473054437915025 83.10405984779926 DOWN 0.2857142857142857 0.7142857142857143 0.0 GO:0007399 5 nervous system development 36 37 7 7 6 7 6 6 156 31 2354 0.99249 0.027049 0.027049 16.22 29482;29540;314322;25661;29496;79431 slc1a2;hsd17b7;fos;fn1;erbb3;bhlhe40 SLC1A2_33059;HSD17B7_8834;FOS_8657;FN1_8655;ERBB3_8571;BHLHE40_8141 32.11426566666688 35.566 1.28141E-12 30.34021952133663 40.15400517461544 28.39432679935798 20.072467000000213 20.07971 1.28141E-12 19.137780348237563 23.968345111675937 17.142452336697993 59.99450333333354 64.96015 1.28142E-12 55.38368123353337 73.43630406530679 50.97402308165217 0.5 0.4887470000006407 2.5 35.566 13.3235;0.977494;1.28141E-12;59.5777;60.9984;57.8085 9.10952;0.322682;1.28141E-12;31.0499;41.6036;38.3491 24.6773;5.49472;1.28142E-12;105.243;113.972;110.58 1 5 1 29496 ERBB3_8571 60.9984 60.9984 41.6036 41.6036 113.972 113.972 60.9984 41.6036 113.972 5 29482;29540;314322;25661;79431 SLC1A2_33059;HSD17B7_8834;FOS_8657;FN1_8655;BHLHE40_8141 26.337438800000257 13.3235 30.006219120339207 15.766240400000257 9.10952 17.85332992308804 49.19900400000025 24.6773 54.40697694048116 13.3235;0.977494;1.28141E-12;59.5777;57.8085 9.10952;0.322682;1.28141E-12;31.0499;38.3491 24.6773;5.49472;1.28142E-12;105.243;110.58 0 Exp 2,1(0.17);Exp 4,1(0.17);Hill,1(0.17);Linear,1(0.17);Poly 2,1(0.17);Power,1(0.17) 1.7182065861469313 10.326111197471619 1.6013026237487793 1.8966681957244873 0.10865403678913589 1.7142949104309082 7.837033872974235 56.39149746035953 4.759053423536054 35.38588057646437 15.67832869428991 104.31067797237719 DOWN 0.16666666666666666 0.8333333333333334 0.0 GO:0046649 4 lymphocyte activation 104 112 6 5 3 4 3 3 159 109 2276 0.064915 0.97839 0.11396 2.68 25513;63868;24330 pik3r1;hspd1;egr1 PIK3R1_32562;HSPD1_8849;EGR1_8533 20.580105666666665 18.7324 0.750017 20.8155374650379 20.657562309490444 22.662178632636802 11.934339666666666 11.6701 0.186019 11.882644210154586 11.82847658044586 12.954819849251237 49.56086 41.5978 4.70178 49.32507403537068 50.4274236089172 53.54189955027205 18.7324;42.2579;0.750017 11.6701;23.9469;0.186019 41.5978;102.383;4.70178 1 2 1 63868 HSPD1_8849 42.2579 42.2579 23.9469 23.9469 102.383 102.383 42.2579 23.9469 102.383 2 25513;24330 PIK3R1_32562;EGR1_8533 9.741208499999999 9.741208499999999 12.715464961193689 5.9280595 5.9280595 8.120471550795587 23.14979 23.14979 26.089425940794484 18.7324;0.750017 11.6701;0.186019 41.5978;4.70178 0 Exp 3,1(0.34);Hill,1(0.34);Poly 2,1(0.34) 2.5144365468143683 8.143716216087341 1.6735800504684448 4.21828556060791 1.3339658542718007 2.2518506050109863 -2.974892404515419 44.13510373784875 -1.5121380868312393 25.380817420164572 -6.255715753354195 105.37743575335418 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0044282 4 small molecule catabolic process 107 120 34 34 22 31 20 20 142 100 2285 0.99999 4.2131E-5 4.2131E-5 16.67 360268;65192;24443;171155;113965;85255;114860;295143;171142;291075;29740;25428;83842;81718;50681;192272;24158;25287;170465;296925 sult1e1;slc27a2;hdc;hadhb;hadh;hacl1;gale;etfdh;ehhadh;eci2;eci1;cyp7a1;crot;cdo1;acox1;acot2;acadm;acadl;acaa2;aass SULT1E1_32446;SLC27A2_9860;HDC_8788;HADHB_8777;HADH_8776;HACL1_8775;GALE_8680;ETFDH_8575;EHHADH_8534;ECI2_8521;ECI1_8520;CYP7A1_8430;CROT_8384;CDO1_8275;ACOX1_7973;ACOT2_7969;ACADM_7957;ACADL_32776;ACAA2_7955;AASS_7936 22.6358905 20.54345 5.72128 16.273310382747148 22.023552599780473 14.598544303996357 16.69670415 15.57525 0.985273 11.126856029434949 16.57698164610337 10.091980972311038 32.386115 29.64895 10.316 21.569632137074358 31.44452060650646 20.287485093390618 5.0 10.6467 11.0 23.1906 50.1846;7.62189;24.5745;31.8029;33.3125;17.6275;71.148;18.1231;8.62809;10.6467;11.9473;5.72128;7.4229;22.9638;23.1906;8.54905;11.7137;33.4878;26.5872;27.4644 36.5009;5.49916;21.0619;25.5756;25.7336;11.195;43.2839;14.869;7.31865;8.92359;7.15307;0.985273;5.75707;18.5144;16.2815;7.19676;8.36151;26.6039;21.3695;21.7498 80.9788;13.3925;29.28;42.1484;46.9856;37.6534;88.9033;23.0103;10.3909;13.0581;19.001;22.3625;10.316;30.0179;33.4539;10.4125;18.9642;45.3228;35.0407;37.0295 17 3 17 360268;65192;24443;171155;113965;85255;295143;171142;291075;29740;83842;50681;192272;24158;25287;170465;296925 SULT1E1_32446;SLC27A2_9860;HDC_8788;HADHB_8777;HADH_8776;HACL1_8775;ETFDH_8575;EHHADH_8534;ECI2_8521;ECI1_8520;CROT_8384;ACOX1_7973;ACOT2_7969;ACADM_7957;ACADL_32776;ACAA2_7955;AASS_7936 20.757925294117644 18.1231 12.072698636691138 15.95003 14.869 9.306656313757376 29.79050588235294 29.28 18.413524082195366 50.1846;7.62189;24.5745;31.8029;33.3125;17.6275;18.1231;8.62809;10.6467;11.9473;7.4229;23.1906;8.54905;11.7137;33.4878;26.5872;27.4644 36.5009;5.49916;21.0619;25.5756;25.7336;11.195;14.869;7.31865;8.92359;7.15307;5.75707;16.2815;7.19676;8.36151;26.6039;21.3695;21.7498 80.9788;13.3925;29.28;42.1484;46.9856;37.6534;23.0103;10.3909;13.0581;19.001;10.316;33.4539;10.4125;18.9642;45.3228;35.0407;37.0295 3 114860;25428;81718 GALE_8680;CYP7A1_8430;CDO1_8275 33.27769333333333 22.9638 33.91085695257691 20.927857666666668 18.5144 21.252342105115762 47.09456666666667 30.0179 36.40918736381426 71.148;5.72128;22.9638 43.2839;0.985273;18.5144 88.9033;22.3625;30.0179 0 Exp 2,6(0.3);Hill,3(0.15);Linear,6(0.3);Poly 2,4(0.2);Power,1(0.05) 3.579382309596801 117.59157693386078 1.693061113357544 32.73371124267578 7.721865890313642 2.2722251415252686 15.503797765983954 29.767983234016043 11.820144484296693 21.573263815703314 22.932806913200185 41.83942308679981 UP 0.85 0.15 0.0 GO:0010675 6 regulation of cellular carbohydrate metabolic process 47 50 7 7 7 6 6 6 156 44 2341 0.96359 0.094288 0.13048 12.0 25106;192280;83516;246186;140942;24158 rgn;ppp1r3b;ppargc1a;fgl1;ddit4;acadm RGN_9699;PPP1R3B_9545;PPARGC1A_33189;FGL1_8640;DDIT4_8450;ACADM_7957 45.120450000000005 39.27525 11.7137 31.391067568450094 37.60062082266599 26.478295127209122 30.658568333333335 26.678800000000003 8.36151 21.202387769456923 26.311393710815274 19.067553570880794 86.67106666666666 67.67745000000001 18.9642 82.58312152355751 63.59915428400752 54.79636883350992 1.5 25.8084 4.0 77.4407 77.4407;36.1411;42.4094;15.4757;87.5421;11.7137 58.7732;27.0588;26.2988;10.2138;53.2453;8.36151 89.8047;53.6244;81.7305;30.4106;245.492;18.9642 2 4 2 25106;24158 RGN_9699;ACADM_7957 44.577200000000005 44.577200000000005 46.47600740704821 33.567355 33.567355 35.646447850074075 54.38445 54.38445 50.09179793264562 77.4407;11.7137 58.7732;8.36151 89.8047;18.9642 4 192280;83516;246186;140942 PPP1R3B_9545;PPARGC1A_33189;FGL1_8640;DDIT4_8450 45.392075 39.27525 30.364952325817455 29.204175 26.678800000000003 17.810613611809302 102.814375 67.67745000000001 97.40532965467462 36.1411;42.4094;15.4757;87.5421 27.0588;26.2988;10.2138;53.2453 53.6244;81.7305;30.4106;245.492 0 Exp 2,2(0.34);Linear,1(0.17);Poly 2,3(0.5) 1.701232221605135 10.229007840156555 1.511321783065796 1.8798987865447998 0.12055007041420301 1.7064738273620605 20.002364645515474 70.23853535448453 13.693124754493226 47.624011912173444 20.590807027669513 152.7513263056638 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0009408 4 response to heat 54 59 9 9 7 8 6 6 156 53 2332 0.92261 0.16914 0.2701 10.17 24651;63868;24464;113936;114851;25303 pklr;hspd1;hp;cpb2;cdkn1a;abcc2 PKLR_9489;HSPD1_8849;HP_8823;CPB2_8369;CDKN1A_8271;ABCC2_32541 34.765928333333335 34.04475 6.24967 20.62305231195461 34.91829141127788 24.31738830268591 22.846024999999997 22.192149999999998 2.44025 13.220624421023013 22.045483287011304 15.96444325206579 67.90531666666668 58.2945 19.0606 46.44173284434665 72.91632704897782 51.69560088661076 1.5 24.46395 4.5 55.58005 23.0963;42.2579;64.9285;25.8316;6.24967;46.2316 17.4625;23.9469;41.6103;20.4374;2.44025;31.1788 32.9443;102.383;136.455;34.8042;19.0606;81.7848 1 5 1 63868 HSPD1_8849 42.2579 42.2579 23.9469 23.9469 102.383 102.383 42.2579 23.9469 102.383 5 24651;24464;113936;114851;25303 PKLR_9489;HP_8823;CPB2_8369;CDKN1A_8271;ABCC2_32541 33.267534 25.8316 22.689181706063795 22.625849999999996 20.4374 14.768803603288259 61.00978 34.8042 48.36765440428139 23.0963;64.9285;25.8316;6.24967;46.2316 17.4625;41.6103;20.4374;2.44025;31.1788 32.9443;136.455;34.8042;19.0606;81.7848 0 Exp 2,4(0.67);Exp 3,1(0.17);Exp 4,1(0.17) 1.8780434302183358 11.526398539543152 1.522104263305664 2.6967689990997314 0.46581840568610144 1.7462945580482483 18.264049666348843 51.26780700031783 12.267322255255008 33.424727744744985 30.744190908494105 105.06644242483922 DOWN 0.16666666666666666 0.8333333333333334 0.0 GO:0044262 4 cellular carbohydrate metabolic process 38 40 7 7 6 5 4 4 158 36 2349 0.8935 0.24762 0.31829 10.0 29573;192280;24158;312382 slc37a4;ppp1r3b;acadm;abcg2 SLC37A4_9871;PPP1R3B_9545;ACADM_7957;ABCG2_32656 23.196984999999998 23.9274 5.21654 17.278213928438905 25.039518554826024 17.618752637448864 15.2112725 15.526305 2.73368 11.531425008723987 16.44490086478705 12.006706848278123 36.002 36.2943 11.386 24.3877787191317 38.70601585618482 24.708575404079667 1.0 11.7137 3.0 39.7166 39.7166;36.1411;11.7137;5.21654 22.6911;27.0588;8.36151;2.73368 60.0334;53.6244;18.9642;11.386 2 2 2 24158;312382 ACADM_7957;ABCG2_32656 8.465119999999999 8.465119999999999 4.594185894453992 5.547595 5.547595 3.979476756365089 15.1751 15.1751 5.3585966091879 11.7137;5.21654 8.36151;2.73368 18.9642;11.386 2 29573;192280 SLC37A4_9871;PPP1R3B_9545 37.92885 37.92885 2.5282602961326943 24.87495 24.87495 3.088430288188487 56.828900000000004 56.828900000000004 4.531847360624452 39.7166;36.1411 22.6911;27.0588 60.0334;53.6244 0 Exp 2,1(0.25);Exp 4,1(0.25);Poly 2,2(0.5) 1.736131825012605 6.973980903625488 1.5074360370635986 1.893584966659546 0.18202600728091228 1.7864799499511719 6.26433535012988 40.12963464987011 3.910475991450495 26.512069008549503 12.101976855250928 59.90202314474908 CONFLICT 0.5 0.5 0.0 GO:0006915 5 apoptotic process 137 149 9 9 8 8 7 7 155 142 2243 0.2548 0.84989 0.48966 4.7 24825;25591;294515;29496;140942;25423;246142 tf;parp1;foxo3;erbb3;ddit4;ctsc;bmf TF_10003;PARP1_9425;FOXO3_8662;ERBB3_8571;DDIT4_8450;CTSC_32456;BMF_8152 54.99757142857144 56.2386 13.1992 29.76675439477819 58.131002939068104 27.380513611545123 37.40894285714286 38.2681 5.6804 21.915937585986526 41.304469837514944 21.400671353710475 100.25312857142856 102.888 32.7581 72.63817842337261 90.27709707287934 49.93860575573894 45.1539;26.9741;13.1992;60.9984;87.5421;56.2386;94.8767 28.132;21.799;5.6804;41.6036;53.2453;38.2681;73.1342 61.5341;35.2797;32.7581;113.972;245.492;102.888;109.848 4 3 4 24825;25591;29496;246142 TF_10003;PARP1_9425;ERBB3_8571;BMF_8152 57.000775 53.07615 28.824274255492252 41.1672 34.8678 22.85551096373331 80.15845 85.69105 38.235211334100555 45.1539;26.9741;60.9984;94.8767 28.132;21.799;41.6036;73.1342 61.5341;35.2797;113.972;109.848 3 294515;140942;25423 FOXO3_8662;DDIT4_8450;CTSC_32456 52.32663333333333 56.2386 37.325518181310414 32.397933333333334 38.2681 24.319725954939 127.04603333333334 102.888 108.40496290854642 13.1992;87.5421;56.2386 5.6804;53.2453;38.2681 32.7581;245.492;102.888 0 Exp 2,2(0.29);Exp 4,1(0.15);Linear,2(0.29);Poly 2,2(0.29) 1.7340788714517192 12.174820303916931 1.5736411809921265 1.9883413314819336 0.1466439811122529 1.701177716255188 32.94605117805724 77.04909167908562 21.173389088769454 53.64449662551627 46.44201294827367 154.06424419458347 CONFLICT 0.5714285714285714 0.42857142857142855 0.0 GO:0048146 7 positive regulation of fibroblast proliferation 27 30 6 6 5 4 4 4 158 26 2359 0.96181 0.1192 0.1192 13.33 24516;25661;24890;114851 jun;fn1;esr1;cdkn1a JUN_8938;FN1_8655;ESR1_33192;CDKN1A_8271 26.4142425 19.9148 6.24967 23.203193908049776 30.850435474380163 28.240867619359378 15.5803375 14.415600000000001 2.44025 12.17916941361869 16.495734297520663 14.870407274743645 49.03705 35.9223 19.0606 38.44388549089005 58.414066314049585 45.83546304405371 0.5 11.341035000000002 2.0 23.3972 16.4324;59.5777;23.3972;6.24967 10.5224;31.0499;18.3088;2.44025 39.929;105.243;31.9156;19.0606 0 4 0 4 24516;25661;24890;114851 JUN_8938;FN1_8655;ESR1_33192;CDKN1A_8271 26.4142425 19.9148 23.203193908049776 15.5803375 14.415600000000001 12.17916941361869 49.03705 35.9223 38.44388549089005 16.4324;59.5777;23.3972;6.24967 10.5224;31.0499;18.3088;2.44025 39.929;105.243;31.9156;19.0606 0 Exp 2,1(0.25);Exp 4,1(0.25);Poly 2,1(0.25);Power,1(0.25) 1.900933588114058 7.716829895973206 1.522104263305664 2.436986207962036 0.3866500429342171 1.8788697123527527 3.6751124701112197 49.153372529888784 3.644751474653683 27.515923525346317 11.362042218927748 86.71205778107225 DOWN 0.0 1.0 0.0 GO:0045859 7 regulation of protein kinase activity 207 223 17 17 14 16 13 13 149 210 2175 0.43543 0.67593 0.88562 5.83 246273;24825;25106;24471;25675;29455;299626;25112;29496;24330;116663;114851;25373 trib3;tf;rgn;hspb1;hmgcr;gdf15;gadd45b;gadd45a;erbb3;egr1;dusp6;cdkn1a;ahsg TRIB3_10079;TF_10003;RGN_9699;HSPB1_8847;HMGCR_8810;GDF15_33113;GADD45B_8679;GADD45A_8678;ERBB3_8571;EGR1_8533;DUSP6_8506;CDKN1A_8271;AHSG_8003 59.89377515384615 62.3934 0.750017 42.613317377022405 61.30478075788377 41.315898103020196 42.53540046153846 41.6036 0.186019 32.718298402202535 45.29103550197875 33.75186944264776 80.42448307692308 106.138 4.70178 51.747722448404 82.3997187635909 49.332134537110605 10.5 105.75800000000001 108.064;45.1539;77.4407;89.1011;1.63089;105.149;106.367;102.919;60.9984;0.750017;62.3934;6.24967;12.402 83.8836;28.132;58.7732;60.3265;0.663137;85.3487;52.7132;89.5012;41.6036;0.186019;39.0875;2.44025;10.3013 143.428;61.5341;89.8047;106.138;7.6286;125.652;109.434;115.437;113.972;4.70178;133.304;19.0606;15.4235 4 9 4 24825;25106;299626;29496 TF_10003;RGN_9699;GADD45B_8679;ERBB3_8571 72.49000000000001 69.21955 26.15007835080674 45.3055 47.1584 13.476969595573046 93.68619999999999 99.61935 23.86301505915245 45.1539;77.4407;106.367;60.9984 28.132;58.7732;52.7132;41.6036 61.5341;89.8047;109.434;113.972 9 246273;24471;25675;29455;25112;24330;116663;114851;25373 TRIB3_10079;HSPB1_8847;HMGCR_8810;GDF15_33113;GADD45A_8678;EGR1_8533;DUSP6_8506;CDKN1A_8271;AHSG_8003 54.295453 62.3934 48.50583418684602 41.30424511111111 39.0875 39.14176634092877 74.53038666666666 106.138 60.63150478978813 108.064;89.1011;1.63089;105.149;102.919;0.750017;62.3934;6.24967;12.402 83.8836;60.3265;0.663137;85.3487;89.5012;0.186019;39.0875;2.44025;10.3013 143.428;106.138;7.6286;125.652;115.437;4.70178;133.304;19.0606;15.4235 0 Exp 2,2(0.16);Exp 4,2(0.16);Hill,1(0.08);Linear,1(0.08);Poly 2,6(0.47);Power,1(0.08) 1.905559103675428 26.186697721481323 1.522104263305664 4.21828556060791 0.8284752234264476 1.6973176002502441 36.72891195322072 83.05863835447161 24.749530848558262 60.32127007451865 52.29410071651144 108.5548654373347 DOWN 0.3076923076923077 0.6923076923076923 0.0 GO:0048839 4 inner ear development 22 23 2 2 2 2 2 2 160 21 2364 0.82335 0.43545 0.65454 8.7 81819;25695 pax8;cebpd PAX8_9432;CEBPD_8283 28.600018 28.600018 0.306936 40.01246028573409 34.015226612209425 39.27273875718314 22.5947171 22.5947171 0.0732342 31.850186561933743 26.90525944953291 31.261363267390493 41.652845 41.652845 1.73689 56.44968491607415 49.292635648490105 55.406083824960376 0.5 28.600018 56.8931;0.306936 45.1162;0.0732342 81.5688;1.73689 1 1 1 81819 PAX8_9432 56.8931 56.8931 45.1162 45.1162 81.5688 81.5688 56.8931 45.1162 81.5688 1 25695 CEBPD_8283 0.306936 0.306936 0.0732342 0.0732342 1.73689 1.73689 0.306936 0.0732342 1.73689 0 Exp 2,1(0.5);Hill,1(0.5) 1.6888067588937814 3.3799068927764893 1.627708911895752 1.7521979808807373 0.08802706486288306 1.6899534463882446 -26.85442271999998 84.05445871999999 -21.547389383999995 66.73682358399999 -36.58242679999998 119.88811679999998 CONFLICT 0.5 0.5 0.0 GO:0009991 4 response to extracellular stimulus 248 265 45 45 35 39 30 30 132 235 2150 0.9996 8.8932E-4 0.0012255 11.32 79426;24522;29573;29482;83516;29441;24651;25513;24314;24539;24516;63868;24464;25675;24957;24384;294515;314322;304929;116636;24330;25146;497840;114851;29184;246142;25698;192272;24158;312382 zfp36;zfp354a;slc37a4;slc1a2;ppargc1a;por;pklr;pik3r1;nqo1;lpl;jun;hspd1;hp;hmgcr;glul;gc;foxo3;fos;f5;eif4ebp1;egr1;cyp17a1;cps1;cdkn1a;cd36;bmf;ass1;acot2;acadm;abcg2 ZFP36_10204;ZFP354A_10203;SLC37A4_9871;SLC1A2_33059;PPARGC1A_33189;POR_9531;PKLR_9489;PIK3R1_32562;NQO1_33055;LPL_32544;JUN_8938;HSPD1_8849;HP_8823;HMGCR_8810;GLUL_32832;GC_32893;FOXO3_8662;FOS_8657;F5_33079;EIF4EBP1_8550;EGR1_8533;CYP17A1_32365;CPS1_32421;CDKN1A_8271;CD36_8243;BMF_8152;ASS1_33159;ACOT2_7969;ACADM_7957;ABCG2_32656 29.937590933333375 20.91435 1.28141E-12 27.996026409849748 34.20994864214547 29.21595739902537 19.808540933333372 14.566299999999998 1.28141E-12 19.298417691954313 22.77844531298043 20.424308936602802 55.418079000000034 38.7184 1.28142E-12 49.48220287628688 60.480483077281136 47.173697966309774 12.5 14.87795 25.5 69.5663 0.348134;0.834827;39.7166;13.3235;42.4094;12.4414;23.0963;18.7324;87.2765;74.2041;16.4324;42.2579;64.9285;1.63089;26.4669;42.356;13.1992;1.28141E-12;10.6089;83.9001;0.750017;49.6922;31.9826;6.24967;48.1296;94.8767;26.8037;8.54905;11.7137;5.21654 0.118102;0.27095;22.6911;9.10952;26.2988;8.48981;17.4625;11.6701;60.6992;49.8682;10.5224;23.9469;41.6103;0.663137;21.0456;26.3722;5.6804;1.28141E-12;2.59129;42.4185;0.186019;35.6654;24.4836;2.44025;37.5433;73.1342;20.9825;7.19676;8.36151;2.73368 1.15962;2.99857;60.0334;24.6773;81.7305;79.2355;32.9443;41.5978;197.117;155.425;39.929;102.383;136.455;7.6286;35.4303;78.7583;32.7581;1.28142E-12;37.5078;107.32;4.70178;81.6409;45.5891;19.0606;69.1421;109.848;36.7081;10.4125;18.9642;11.386 10 20 10 24314;24539;63868;116636;25146;29184;246142;192272;24158;312382 NQO1_33055;LPL_32544;HSPD1_8849;EIF4EBP1_8550;CYP17A1_32365;CD36_8243;BMF_8152;ACOT2_7969;ACADM_7957;ABCG2_32656 50.581638999999996 48.9109 33.97424092075068 34.156765 36.60435 23.656053989290054 86.36386999999999 92.01195 61.94520398648128 87.2765;74.2041;42.2579;83.9001;49.6922;48.1296;94.8767;8.54905;11.7137;5.21654 60.6992;49.8682;23.9469;42.4185;35.6654;37.5433;73.1342;7.19676;8.36151;2.73368 197.117;155.425;102.383;107.32;81.6409;69.1421;109.848;10.4125;18.9642;11.386 20 79426;24522;29573;29482;83516;29441;24651;25513;24516;24464;25675;24957;24384;294515;314322;304929;24330;497840;114851;25698 ZFP36_10204;ZFP354A_10203;SLC37A4_9871;SLC1A2_33059;PPARGC1A_33189;POR_9531;PKLR_9489;PIK3R1_32562;JUN_8938;HP_8823;HMGCR_8810;GLUL_32832;GC_32893;FOXO3_8662;FOS_8657;F5_33079;EGR1_8533;CPS1_32421;CDKN1A_8271;ASS1_33159 19.615566900000065 14.87795 17.694267765720966 12.634428900000064 9.81596 11.86743845875409 39.94518350000008 36.0692 34.110238670980756 0.348134;0.834827;39.7166;13.3235;42.4094;12.4414;23.0963;18.7324;16.4324;64.9285;1.63089;26.4669;42.356;13.1992;1.28141E-12;10.6089;0.750017;31.9826;6.24967;26.8037 0.118102;0.27095;22.6911;9.10952;26.2988;8.48981;17.4625;11.6701;10.5224;41.6103;0.663137;21.0456;26.3722;5.6804;1.28141E-12;2.59129;0.186019;24.4836;2.44025;20.9825 1.15962;2.99857;60.0334;24.6773;81.7305;79.2355;32.9443;41.5978;39.929;136.455;7.6286;35.4303;78.7583;32.7581;1.28142E-12;37.5078;4.70178;45.5891;19.0606;36.7081 0 Exp 2,8(0.27);Exp 3,3(0.1);Exp 4,4(0.14);Hill,5(0.17);Linear,3(0.1);Poly 2,7(0.24) 2.0758675434899536 70.97503685951233 1.5074360370635986 11.836054801940918 1.9251156549555533 1.8875073790550232 19.919341545679128 39.95584032098763 12.902690853227146 26.71439101343962 37.71110010921237 73.12505789078774 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0033209 7 tumor necrosis factor-mediated signaling pathway 17 18 2 2 2 2 2 2 160 16 2369 0.89794 0.31912 0.31912 11.11 25493;294515 nfkbia;foxo3 NFKBIA_9307;FOXO3_8662 6.8596755 6.8596755 0.520151 8.965441526896512 7.832275104350671 8.85930255671598 2.920301 2.920301 0.160202 3.9033694392924168 3.343750928361139 3.8571587076426974 17.821545 17.821545 2.88499 21.12347865613166 20.113087131174357 20.8734046062964 0.0 0.520151 0.5 6.8596755 0.520151;13.1992 0.160202;5.6804 2.88499;32.7581 0 2 0 2 25493;294515 NFKBIA_9307;FOXO3_8662 6.8596755 6.8596755 8.965441526896512 2.920301 2.920301 3.9033694392924168 17.821545 17.821545 21.12347865613166 0.520151;13.1992 0.160202;5.6804 2.88499;32.7581 0 Exp 4,2(1) 1.9203098877027045 3.842947483062744 1.8546061515808105 1.9883413314819336 0.09456505259128699 1.921473741531372 -5.565792519999997 19.28514352 -2.4894930399999997 8.33009504 -11.454102799999994 47.097192799999995 DOWN 0.0 1.0 0.0 GO:0050776 5 regulation of immune response 176 199 12 11 6 9 4 4 158 195 2190 0.0029667 0.99923 0.0058583 2.01 63868;246186;29184;313421 hspd1;fgl1;cd36;c8b HSPD1_8849;FGL1_8640;CD36_8243;C8B_8181 31.80625 31.809849999999997 15.4757 15.826793126951952 32.10107325512377 16.83931720126243 22.2282 20.577849999999998 10.2138 11.648267416515921 22.53803780943403 13.001908434170083 57.46295 49.77635 27.9161 35.39801982300705 57.50789431234943 33.46115817730601 42.2579;15.4757;48.1296;21.3618 23.9469;10.2138;37.5433;17.2088 102.383;30.4106;69.1421;27.9161 2 2 2 63868;29184 HSPD1_8849;CD36_8243 45.19375 45.19375 4.151918887092963 30.7451 30.7451 9.61410663972478 85.76255 85.76255 23.504865802743858 42.2579;48.1296 23.9469;37.5433 102.383;69.1421 2 246186;313421 FGL1_8640;C8B_8181 18.41875 18.41875 4.162101224742132 13.711300000000001 13.711300000000001 4.946211934399888 29.16335 29.16335 1.763877865669791 15.4757;21.3618 10.2138;17.2088 30.4106;27.9161 0 Exp 2,2(0.5);Exp 3,1(0.25);Poly 2,1(0.25) 1.925397091573081 7.945730805397034 1.511321783065796 2.6703107357025146 0.574084095774884 1.8820491433143616 16.295992735587095 47.316507264412905 10.81289793181439 33.64350206818561 22.77289057345309 92.1530094265469 CONFLICT 0.5 0.5 0.0 GO:1902895 10 positive regulation of pri-miRNA transcription by RNA polymerase II 28 29 5 5 5 5 5 5 157 24 2361 0.99158 0.033484 0.033484 17.24 24516;290556;294515;314322;24330 jun;gnl3;foxo3;fos;egr1 JUN_8938;GNL3_8735;FOXO3_8662;FOS_8657;EGR1_8533 23.60346340000026 13.1992 1.28141E-12 36.53492735730608 12.465357358351016 25.580928732294115 14.159763800000254 5.6804 1.28141E-12 22.9182023434942 7.407429143484733 15.979107608095687 63.27037600000026 32.7581 1.28142E-12 99.72103321876402 33.58031150760376 68.9696355849903 0.5 0.37500850000064073 1.5 6.9746084999999995 16.4324;87.6357;13.1992;1.28141E-12;0.750017 10.5224;54.41;5.6804;1.28141E-12;0.186019 39.929;238.963;32.7581;1.28142E-12;4.70178 1 4 1 290556 GNL3_8735 87.6357 87.6357 54.41 54.41 238.963 238.963 87.6357 54.41 238.963 4 24516;294515;314322;24330 JUN_8938;FOXO3_8662;FOS_8657;EGR1_8533 7.595404250000321 6.9746084999999995 8.44678465485728 4.09720475000032 2.9332095 5.029052327382706 19.34722000000032 18.72994 19.93543917135805 16.4324;13.1992;1.28141E-12;0.750017 10.5224;5.6804;1.28141E-12;0.186019 39.929;32.7581;1.28142E-12;4.70178 0 Exp 2,1(0.2);Exp 4,1(0.2);Hill,2(0.4);Poly 2,1(0.2) 2.1850501229115062 11.664328932762146 1.582527995109558 4.21828556060791 1.0668119479084144 1.9785058498382568 -8.420812400589384 55.6277392005899 -5.928926277961766 34.24845387796228 -24.13896355295877 150.6797155529593 DOWN 0.2 0.8 0.0 GO:0071396 6 cellular response to lipid 195 209 34 34 26 29 22 22 140 187 2198 0.99457 0.010985 0.016716 10.53 79426;286954;83516;25513;81525;24539;24516;24471;294515;25661;24890;25315;116636;24330;140942;25428;25146;497840;29184;25698;312382;25303 zfp36;ugt2b1;ppargc1a;pik3r1;nfkbib;lpl;jun;hspb1;foxo3;fn1;esr1;ephx1;eif4ebp1;egr1;ddit4;cyp7a1;cyp17a1;cps1;cd36;ass1;abcg2;abcc2 ZFP36_10204;UGT2B10_33303,UGT2B1_33224;PPARGC1A_33189;PIK3R1_32562;NFKBIB_9308;LPL_32544;JUN_8938;HSPB1_8847;FOXO3_8662;FN1_8655;ESR1_33192;EPHX1_8567;EIF4EBP1_8550;EGR1_8533;DDIT4_8450;CYP7A1_8430;CYP17A1_32365;CPS1_32421;CD36_8243;ASS1_33159;ABCG2_32656;ABCC2_32541 36.99439640909091 31.2699 0.348134 28.282615891778622 40.84879033522203 27.58004805384337 24.06104427272727 24.36375 0.118102 18.055238069551187 26.752125728196106 17.49722916121766 65.61107954545454 43.593450000000004 1.15962 56.06034755589225 67.86450301121084 48.502974695643054 9.5 28.68045 19.5 85.7211 0.348134;47.47345;42.4094;18.7324;30.5572;74.2041;16.4324;89.1011;13.1992;59.5777;23.3972;12.4747;83.9001;0.750017;87.5421;5.72128;49.6922;31.9826;48.1296;26.8037;5.21654;46.2316 0.118102;34.82915;26.2988;11.6701;24.2439;49.8682;10.5224;60.3265;5.6804;31.0499;18.3088;7.00435;42.4185;0.186019;53.2453;0.985273;35.6654;24.4836;37.5433;20.9825;2.73368;31.1788 1.15962;76.47475;81.7305;41.5978;41.2611;155.425;39.929;106.138;32.7581;105.243;31.9156;23.684;107.32;4.70178;245.492;22.3625;81.6409;45.5891;69.1421;36.7081;11.386;81.7848 9 14 8 286954;81525;24539;25315;116636;25146;29184;312382 UGT2B10_33303,UGT2B1_33224;NFKBIB_9308;LPL_32544;EPHX1_8567;EIF4EBP1_8550;CYP17A1_32365;CD36_8243;ABCG2_32656 43.95598625 47.801525 27.37183096475693 29.288310000000003 35.247275 16.744364196813034 70.79173125 72.808425 46.705864538490374 47.47345;30.5572;74.2041;12.4747;83.9001;49.6922;48.1296;5.21654 34.82915;24.2439;49.8682;7.00435;42.4185;35.6654;37.5433;2.73368 76.47475;41.2611;155.425;23.684;107.32;81.6409;69.1421;11.386 14 79426;83516;25513;24516;24471;294515;25661;24890;24330;140942;25428;497840;25698;25303 ZFP36_10204;PPARGC1A_33189;PIK3R1_32562;JUN_8938;HSPB1_8847;FOXO3_8662;FN1_8655;ESR1_33192;EGR1_8533;DDIT4_8450;CYP7A1_8430;CPS1_32421;ASS1_33159;ABCC2_32541 33.016345071428574 25.100450000000002 29.014923645018907 21.074035285714285 19.645650000000003 18.68710447323308 62.650707142857144 40.763400000000004 62.259100644917815 0.348134;42.4094;18.7324;16.4324;89.1011;13.1992;59.5777;23.3972;0.750017;87.5421;5.72128;31.9826;26.8037;46.2316 0.118102;26.2988;11.6701;10.5224;60.3265;5.6804;31.0499;18.3088;0.186019;53.2453;0.985273;24.4836;20.9825;31.1788 1.15962;81.7305;41.5978;39.929;106.138;32.7581;105.243;31.9156;4.70178;245.492;22.3625;45.5891;36.7081;81.7848 0 Exp 2,10(0.44);Exp 3,1(0.05);Exp 4,2(0.09);Hill,4(0.18);Linear,2(0.09);Poly 2,3(0.14);Power,1(0.05) 1.9889647283114917 47.97239792346954 1.5074360370635986 4.560328960418701 0.7857467487268315 1.8264755010604858 25.175843430756863 48.81294938742494 16.516240479544447 31.6058480659101 42.184951279655536 89.03720781125355 DOWN 0.36363636363636365 0.6363636363636364 0.0 GO:0042359 5 vitamin D metabolic process 3 3 1 1 1 1 1 1 161 2 2383 0.98844 0.179 0.179 33.33 24384 gc GC_32893 42.356 42.356 42.356 42.356 26.3722 26.3722 26.3722 26.3722 78.7583 78.7583 78.7583 78.7583 0.0 42.356 0.0 42.356 42.356 26.3722 78.7583 0 1 0 1 24384 GC_32893 42.356 42.356 26.3722 26.3722 78.7583 78.7583 42.356 26.3722 78.7583 0 Exp 3,1(1) 1.5294301509857178 1.5294301509857178 1.5294301509857178 1.5294301509857178 0.0 1.5294301509857178 42.356 42.356 26.3722 26.3722 78.7583 78.7583 DOWN 0.0 1.0 0.0 GO:0007265 7 Ras protein signal transduction 42 44 4 4 3 4 3 3 159 41 2344 0.69437 0.53806 0.75678 6.82 308821;24516;114851 rab30;jun;cdkn1a RAB30_9639;JUN_8938;CDKN1A_8271 16.36745666666667 16.4324 6.24967 10.08547182221205 14.550855155096013 10.867030551504582 11.32505 10.5224 2.44025 9.31210517458324 9.831741621532906 9.960041572253681 31.448566666666665 35.3561 19.0606 10.969236172283539 28.228424749712786 11.220009053778663 1.5 21.42635 26.4203;16.4324;6.24967 21.0125;10.5224;2.44025 35.3561;39.929;19.0606 1 2 1 308821 RAB30_9639 26.4203 26.4203 21.0125 21.0125 35.3561 35.3561 26.4203 21.0125 35.3561 2 24516;114851 JUN_8938;CDKN1A_8271 11.341035000000002 11.341035000000002 7.200277433991694 6.481325 6.481325 5.714943071566854 29.4948 29.4948 14.756187152513343 16.4324;6.24967 10.5224;2.44025 39.929;19.0606 0 Exp 4,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 2.0699610861249966 6.44574236869812 1.522104263305664 2.945132255554199 0.7265991195448017 1.9785058498382568 4.954670918607977 27.780242414725354 0.7874109986352256 21.862689001364778 19.03570741119662 43.86142592213672 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0033540 8 fatty acid beta-oxidation using acyl-CoA oxidase 3 3 2 2 1 2 1 1 161 2 2383 0.98844 0.179 0.179 33.33 50681 acox1 ACOX1_7973 23.1906 23.1906 23.1906 23.190599999999996 16.2815 16.2815 16.2815 16.2815 33.4539 33.4539 33.4539 33.4539 0.0 23.1906 0.0 23.1906 23.1906 16.2815 33.4539 1 0 1 50681 ACOX1_7973 23.1906 23.1906 16.2815 16.2815 33.4539 33.4539 23.1906 16.2815 33.4539 0 0 Power,1(1) 5.973292827606201 5.973292827606201 5.973292827606201 5.973292827606201 0.0 5.973292827606201 23.1906 23.1906 16.2815 16.2815 33.4539 33.4539 UP 1.0 0.0 0.0 GO:0005996 4 monosaccharide metabolic process 56 69 12 12 9 10 7 7 155 62 2323 0.93164 0.14547 0.20412 10.14 286954;25106;501907;83516;25513;25685;114860 ugt2b1;rgn;rgd1559459;ppargc1a;pik3r1;igfbp1;gale UGT2B10_33303,UGT2B1_33224;RGN_9699;RGD1559459_9690;PPARGC1A_33189;PIK3R1_32562;IGFBP1_32306;GALE_8680 43.74712142857146 47.47345 2.52378E-13 27.292101517103397 46.70174576626588 24.437017617875593 29.649064285714324 32.6883 2.52378E-13 19.509522069934448 32.48596143612858 18.310839883308898 66.8104785714286 81.7305 2.52379E-13 33.989594702691136 70.90161832790996 28.266787116651994 2.5 44.941424999999995 5.5 74.29435000000001 47.47345;77.4407;2.52378E-13;42.4094;18.7324;49.0259;71.148 34.82915;58.7732;2.52378E-13;26.2988;11.6701;32.6883;43.2839 76.47475;89.8047;2.52379E-13;81.7305;41.5978;89.1623;88.9033 3 5 2 286954;25106 UGT2B10_33303,UGT2B1_33224;RGN_9699 62.457075 62.457075 21.190045688512583 46.801175 46.801175 16.931000124069765 83.139725 83.139725 9.425698037877623 47.47345;77.4407 34.82915;58.7732 76.47475;89.8047 5 501907;83516;25513;25685;114860 RGD1559459_9690;PPARGC1A_33189;PIK3R1_32562;IGFBP1_32306;GALE_8680 36.26314000000005 42.4094 27.56791694901876 22.78822000000005 26.2988 17.126910241692666 60.278780000000054 81.7305 39.03942717250079 2.52378E-13;42.4094;18.7324;49.0259;71.148 2.52378E-13;26.2988;11.6701;32.6883;43.2839 2.52379E-13;81.7305;41.5978;89.1623;88.9033 0 Exp 2,4(0.5);Hill,1(0.13);Poly 2,3(0.38) 1.9059947681679612 15.987886309623718 1.6167030334472656 3.9562058448791504 0.7946182428655976 1.7387548089027405 23.528849684807895 63.96539317233504 15.196208079177984 44.101920492250656 41.630634442212866 91.99032270064437 DOWN 0.2857142857142857 0.7142857142857143 0.0 GO:0042632 8 cholesterol homeostasis 34 35 9 9 6 9 6 6 156 29 2356 0.99454 0.020971 0.020971 17.14 29573;24539;25675;65030;25428;50681 slc37a4;lpl;hmgcr;ephx2;cyp7a1;acox1 SLC37A4_9871;LPL_32544;HMGCR_8810;EPHX2_33282;CYP7A1_8430;ACOX1_7973 30.532128333333333 30.95995 1.63089 26.696617998809078 45.06780381561474 23.996801570537407 19.949818333333333 19.4863 0.663137 18.61964667311 29.81649786681345 16.58665204656884 56.01911666666666 45.3326 7.6286 52.69281614221875 81.75614020060112 56.012908061773594 0.5 3.676085 2.5 30.95995 39.7166;74.2041;1.63089;38.7293;5.72128;23.1906 22.6911;49.8682;0.663137;29.2097;0.985273;16.2815 60.0334;155.425;7.6286;57.2113;22.3625;33.4539 3 3 3 24539;65030;50681 LPL_32544;EPHX2_33282;ACOX1_7973 45.37466666666666 38.7293 26.147943880223806 31.78646666666667 29.2097 16.940968067478707 82.03006666666667 57.2113 64.66232050385553 74.2041;38.7293;23.1906 49.8682;29.2097;16.2815 155.425;57.2113;33.4539 3 29573;25675;25428 SLC37A4_9871;HMGCR_8810;CYP7A1_8430 15.68959 5.72128 20.908269410525108 8.113169999999998 0.985273 12.625885125974296 30.008166666666668 22.3625 27.02606019832216 39.7166;1.63089;5.72128 22.6911;0.663137;0.985273 60.0334;7.6286;22.3625 0 Exp 2,1(0.17);Exp 4,1(0.17);Hill,1(0.17);Linear,1(0.17);Poly 2,1(0.17);Power,1(0.17) 2.986993128241266 20.531339406967163 1.559399127960205 5.973292827606201 1.866122874569827 3.2310495376586914 9.170384961339352 51.893871705327314 5.050998043590241 34.848638623076425 13.856082531483281 98.18215080185006 CONFLICT 0.5 0.5 0.0 GO:0006886 5 intracellular protein transport 114 122 10 10 9 10 9 9 153 113 2272 0.75494 0.37168 0.57022 7.38 171139;297784;308821;25513;25493;63868;24471;85255;114851 timm9;rrs1;rab30;pik3r1;nfkbia;hspd1;hspb1;hacl1;cdkn1a TIMM9_10020;RRS1_9755;RAB30_9639;PIK3R1_32562;NFKBIA_9307;HSPD1_8849;HSPB1_8847;HACL1_8775;CDKN1A_8271 171139(0.04986) 33.31312455555556 26.4203 0.520151 27.987773312234204 36.0015987802769 30.476693450825955 22.601161333333337 21.0125 0.160202 19.544952866165495 23.886402896281247 21.21908278252012 56.16493222222222 41.5978 2.88499 39.07760552538173 60.34699395076313 40.09748111062586 5.5 40.3885 38.5191;60.39;26.4203;18.7324;0.520151;42.2579;89.1011;17.6275;6.24967 29.55;43.109;21.0125;11.6701;0.160202;23.9469;60.3265;11.195;2.44025 55.4685;104.942;35.3561;41.5978;2.88499;102.383;106.138;37.6534;19.0606 5 4 5 171139;297784;308821;63868;85255 TIMM9_10020;RRS1_9755;RAB30_9639;HSPD1_8849;HACL1_8775 37.04296000000001 38.5191 16.311497921343694 25.76268 23.9469 11.761347477521442 67.1606 55.4685 34.23068039865698 38.5191;60.39;26.4203;42.2579;17.6275 29.55;43.109;21.0125;23.9469;11.195 55.4685;104.942;35.3561;102.383;37.6534 4 25513;25493;24471;114851 PIK3R1_32562;NFKBIA_9307;HSPB1_8847;CDKN1A_8271 28.65083025 12.491035 41.01120768393457 18.649263 7.055175 28.226927328531694 42.420347500000005 30.3292 45.34805442506906 18.7324;0.520151;89.1011;6.24967 11.6701;0.160202;60.3265;2.44025 41.5978;2.88499;106.138;19.0606 0 Exp 2,2(0.23);Exp 3,1(0.12);Exp 4,2(0.23);Linear,1(0.12);Poly 2,3(0.34) 1.9097543638984706 17.565302968025208 1.522104263305664 2.945132255554199 0.45910974130458126 1.7180453538894653 15.027779324895878 51.59846978621525 9.831792127438538 35.37053053922813 30.6342299456395 81.69563449880495 CONFLICT 0.5555555555555556 0.4444444444444444 0.0 GO:0048232 5 male gamete generation 67 75 4 4 4 4 4 4 158 71 2314 0.47504 0.71416 1.0 5.33 25106;24464;29328;50681 rgn;hp;gpx4;acox1 RGN_9699;HP_8823;GPX4_32827;ACOX1_7973 52.870050000000006 55.42445 23.1906 23.65227575555186 56.23784405065684 22.26603802035155 37.7212 37.91505 16.2815 17.609016069994745 39.47682907570173 16.47223340438467 82.53569999999999 80.11695 33.4539 42.87858714626688 92.31698722710519 44.5356546737576 2.5 71.1846 77.4407;64.9285;45.9204;23.1906 58.7732;41.6103;34.2198;16.2815 89.8047;136.455;70.4292;33.4539 3 1 3 25106;29328;50681 RGN_9699;GPX4_32827;ACOX1_7973 48.85056666666667 45.9204 27.24348995674625 36.42483333333333 34.2198 21.33149716319353 64.56259999999999 70.4292 28.62980809977603 77.4407;45.9204;23.1906 58.7732;34.2198;16.2815 89.8047;70.4292;33.4539 1 24464 HP_8823 64.9285 64.9285 41.6103 41.6103 136.455 136.455 64.9285 41.6103 136.455 0 Exp 2,2(0.5);Poly 2,1(0.25);Power,1(0.25) 2.257586061767674 10.874591588973999 1.547789216041565 5.973292827606201 2.1709004997251173 1.6767547726631165 29.690819759559176 76.04928024044084 20.464364251405147 54.97803574859486 40.51468459665848 124.5567154033415 UP 0.75 0.25 0.0 GO:0045936 8 negative regulation of phosphate metabolic process 156 168 17 17 15 16 14 14 148 154 2231 0.89077 0.17653 0.25477 8.33 246273;293615;25106;83516;25591;24516;24471;25675;299626;25112;116663;140942;114851;25373 trib3;sirt3;rgn;ppargc1a;parp1;jun;hspb1;hmgcr;gadd45b;gadd45a;dusp6;ddit4;cdkn1a;ahsg TRIB3_10079;SIRT3_9828;RGN_9699;PPARGC1A_33189;PARP1_9425;JUN_8938;HSPB1_8847;HMGCR_8810;GADD45B_8679;GADD45A_8678;DUSP6_8506;DDIT4_8450;CDKN1A_8271;AHSG_8003 53.021852857142854 52.401399999999995 1.63089 41.8014084976813 52.74761442176674 40.79505704708458 36.43696264285714 32.69315 0.56209 30.489991929703294 38.37517254722864 32.25620319043709 82.20848357142857 85.7676 7.6286 67.29981191441034 75.95856340112587 55.81587783074542 7.5 69.91705 108.064;2.38018;77.4407;42.4094;26.9741;16.4324;89.1011;1.63089;106.367;102.919;62.3934;87.5421;6.24967;12.402 83.8836;0.56209;58.7732;26.2988;21.799;10.5224;60.3265;0.663137;52.7132;89.5012;39.0875;53.2453;2.44025;10.3013 143.428;8.82917;89.8047;81.7305;35.2797;39.929;106.138;7.6286;109.434;115.437;133.304;245.492;19.0606;15.4235 4 10 4 293615;25106;25591;299626 SIRT3_9828;RGN_9699;PARP1_9425;GADD45B_8679 53.29049500000001 52.20740000000001 47.20438045969992 33.4618725 37.2561 27.262276707464448 60.8368925 62.542199999999994 46.75748074494845 2.38018;77.4407;26.9741;106.367 0.56209;58.7732;21.799;52.7132 8.82917;89.8047;35.2797;109.434 10 246273;83516;24516;24471;25675;25112;116663;140942;114851;25373 TRIB3_10079;PPARGC1A_33189;JUN_8938;HSPB1_8847;HMGCR_8810;GADD45A_8678;DUSP6_8506;DDIT4_8450;CDKN1A_8271;AHSG_8003 52.914395999999996 52.401399999999995 42.20385189523297 37.6269987 32.69315 33.00850598276022 90.75712 93.93425 74.35940006622192 108.064;42.4094;16.4324;89.1011;1.63089;102.919;62.3934;87.5421;6.24967;12.402 83.8836;26.2988;10.5224;60.3265;0.663137;89.5012;39.0875;53.2453;2.44025;10.3013 143.428;81.7305;39.929;106.138;7.6286;115.437;133.304;245.492;19.0606;15.4235 0 Exp 2,4(0.29);Exp 4,2(0.15);Hill,1(0.08);Linear,1(0.08);Poly 2,5(0.36);Power,1(0.08) 1.7949137842514753 25.705007910728455 1.5209722518920898 3.431420087814331 0.48028384768387955 1.7086020708084106 31.124936013536264 74.91876970074944 20.465328149153834 52.408597136560445 46.95468619850152 117.46228094435563 DOWN 0.2857142857142857 0.7142857142857143 0.0 GO:0072655 7 establishment of protein localization to mitochondrion 20 21 2 2 2 2 2 2 160 19 2366 0.85485 0.39001 0.39001 9.52 171139;63868 timm9;hspd1 TIMM9_10020;HSPD1_8849 171139(0.04986) 40.3885 40.3885 38.5191 2.643730833500315 41.6967166064982 1.888505054524459 26.74845 26.74845 23.9469 3.961990005666374 24.78790959455707 2.830181521077915 78.92575 78.92575 55.4685 33.1735610859763 95.3412651346848 23.69698041630764 0.5 40.3885 38.5191;42.2579 29.55;23.9469 55.4685;102.383 2 0 2 171139;63868 TIMM9_10020;HSPD1_8849 40.3885 40.3885 2.643730833500315 26.74845 26.74845 3.961990005666374 78.92575 78.92575 33.1735610859763 38.5191;42.2579 29.55;23.9469 55.4685;102.383 0 0 Exp 2,1(0.5);Exp 3,1(0.5) 1.9103932048989252 3.8725630044937134 1.620712399482727 2.2518506050109863 0.4462821049949411 1.9362815022468567 36.724476 44.052524 21.257412 32.239488 32.94954 124.90195999999999 UP 1.0 0.0 0.0 GO:0010951 8 negative regulation of endopeptidase activity 84 91 16 16 14 16 14 14 148 77 2308 0.99954 0.001455 0.001455 15.38 79224;24794;24648;252922;29441;299282;288001;54404;50693;306251;83928;24360;25377;25373 serpind1;serpina3c;serpina1;pzp;por;loc299282;kng1;itih4;itih3;itih1;fetub;fabp1;ambp;ahsg SERPIND1_9812;SERPINA3C_32925;SERPINA1_9807;PZP_9633;POR_9531;LOC299282_9119;KNG1L1_34113;ITIH4_32725;ITIH3_32422;ITIH1_33132;FETUB_33027;FABP1_33091;AMBP_33085;AHSG_8003 33.4596 29.0135 12.402 22.37954241204023 40.593328536630494 26.056405956936135 22.73687214285715 21.9089 8.48981 10.121908113467512 25.66643620667859 11.41552383686934 51.03775714285715 43.87565 15.4235 28.982531777838275 63.27773729187223 29.94885499959723 3.5 20.7999 8.5 33.181650000000005 28.261;29.766;15.797;34.1871;12.4414;45.2017;24.3655;57.1163;27.1247;98.1741;32.5155;33.8478;17.2343;12.402 22.307;23.347;13.013;26.3085;8.48981;30.7472;19.538;39.6402;21.5108;42.9071;19.6094;26.4736;14.1233;10.3013 38.3264;40.8256;19.9134;48.5666;79.2355;78.6415;32.1467;101.869;36.4819;104.278;49.9875;46.9257;21.9073;15.4235 1 13 1 24360 FABP1_33091 33.8478 33.8478 26.4736 26.4736 46.9257 46.9257 33.8478 26.4736 46.9257 13 79224;24794;24648;252922;29441;299282;288001;54404;50693;306251;83928;25377;25373 SERPIND1_9812;SERPINA3C_32925;SERPINA1_9807;PZP_9633;POR_9531;LOC299282_9119;KNG1L1_34113;ITIH4_32725;ITIH3_32422;ITIH1_33132;FETUB_33027;AMBP_33085;AHSG_8003 33.42973846153846 28.261 23.29307595608397 22.449431538461543 21.5108 10.475575114503133 51.35406923076924 40.8256 30.14081288990019 28.261;29.766;15.797;34.1871;12.4414;45.2017;24.3655;57.1163;27.1247;98.1741;32.5155;17.2343;12.402 22.307;23.347;13.013;26.3085;8.48981;30.7472;19.538;39.6402;21.5108;42.9071;19.6094;14.1233;10.3013 38.3264;40.8256;19.9134;48.5666;79.2355;78.6415;32.1467;101.869;36.4819;104.278;49.9875;21.9073;15.4235 0 Exp 2,5(0.36);Exp 3,1(0.08);Linear,6(0.43);Poly 2,2(0.15) 1.9146444877382427 27.664738297462463 1.5197933912277222 3.431420087814331 0.5672154725334544 1.6912026405334473 21.736478774991646 45.18272122500834 17.434692426316744 28.03905185939754 35.85577856690287 66.21973571881142 DOWN 0.07142857142857142 0.9285714285714286 0.0 GO:0043567 6 regulation of insulin-like growth factor receptor signaling pathway 8 8 1 1 1 1 1 1 161 7 2378 0.91259 0.40932 0.40932 12.5 25685 igfbp1 IGFBP1_32306 49.0259 49.0259 49.0259 49.0259 32.6883 32.6883 32.6883 32.6883 89.1623 89.1623 89.1623 89.1623 0.0 49.0259 0.0 49.0259 49.0259 32.6883 89.1623 0 1 0 1 25685 IGFBP1_32306 49.0259 49.0259 32.6883 32.6883 89.1623 89.1623 49.0259 32.6883 89.1623 0 Exp 2,1(1) 3.956205844879151 3.9562058448791504 3.9562058448791504 3.9562058448791504 0.0 3.9562058448791504 49.0259 49.0259 32.6883 32.6883 89.1623 89.1623 DOWN 0.0 1.0 0.0 GO:0033137 10 negative regulation of peptidyl-serine phosphorylation 12 12 2 2 2 2 2 2 160 10 2375 0.96369 0.17482 0.17482 16.67 25112;140942 gadd45a;ddit4 GADD45A_8678;DDIT4_8450 95.23055 95.23055 87.5421 10.873110263627552 100.19286193034458 8.30514583959338 71.37325 71.37325 53.2453 25.63679274802134 83.07346819192294 19.582005283621733 180.4645 180.4645 115.437 91.96277242721644 138.494175805854 70.24340030619662 0.0 87.5421 0.5 95.23055 102.919;87.5421 89.5012;53.2453 115.437;245.492 0 2 0 2 25112;140942 GADD45A_8678;DDIT4_8450 95.23055 95.23055 10.873110263627552 71.37325 71.37325 25.63679274802134 180.4645 180.4645 91.96277242721644 102.919;87.5421 89.5012;53.2453 115.437;245.492 0 Linear,1(0.5);Poly 2,1(0.5) 1.6505062601356135 3.3011800050735474 1.6339634656906128 1.6672165393829346 0.023513473903136715 1.6505900025367737 80.16118800000001 110.29991199999998 35.842468000000004 106.904032 53.01060000000001 307.91839999999996 DOWN 0.0 1.0 0.0 GO:0051353 6 positive regulation of oxidoreductase activity 20 23 5 5 4 5 4 4 158 19 2366 0.9871 0.054087 0.054087 17.39 293615;25106;29441;24890 sirt3;rgn;por;esr1 SIRT3_9828;RGN_9699;POR_9531;ESR1_33192 28.91487 17.9193 2.38018 33.469716892811235 29.246727511416786 35.89550380325516 21.533475000000003 13.399305000000002 0.56209 25.86588378786299 21.576519148280607 27.7857370188839 52.4462425 55.57555 8.82917 38.45896063387429 58.006237861348005 39.763974185679295 0.5 7.41079 1.5 17.9193 2.38018;77.4407;12.4414;23.3972 0.56209;58.7732;8.48981;18.3088 8.82917;89.8047;79.2355;31.9156 2 2 2 293615;25106 SIRT3_9828;RGN_9699 39.91044 39.91044 53.075802691388475 29.667645 29.667645 41.161470621396056 49.316935 49.316935 57.25834637317472 2.38018;77.4407 0.56209;58.7732 8.82917;89.8047 2 29441;24890 POR_9531;ESR1_33192 17.9193 17.9193 7.7469204733235815 13.399305000000002 13.399305000000002 6.943074413402896 55.57555 55.57555 33.460222175069326 12.4414;23.3972 8.48981;18.3088 79.2355;31.9156 0 Exp 2,1(0.25);Hill,1(0.25);Poly 2,2(0.5) 1.8853436147745584 7.659773111343384 1.5209722518920898 2.436986207962036 0.39592764001201497 1.850907325744629 -3.8854525549550054 61.71519255495501 -3.8150911121057263 46.88204111210573 14.756461078803206 90.1360239211968 CONFLICT 0.5 0.5 0.0 GO:0014072 6 response to isoquinoline alkaloid 19 19 4 4 4 3 3 3 159 16 2369 0.97118 0.11579 0.11579 15.79 361969;24330;312382 fga;egr1;abcg2 FGA_8632;EGR1_8533;ABCG2_32656 11.515619000000001 5.21654 0.750017 14.946235651534566 13.075279368227692 15.250958098707668 8.482899666666667 2.73368 0.186019 12.230794948541993 9.722532238207846 12.532605876816021 18.31296 11.386 4.70178 18.09782017942493 20.24125242008361 18.40302801263221 0.0 0.750017 0.5 2.9832785 28.5803;0.750017;5.21654 22.529;0.186019;2.73368 38.8511;4.70178;11.386 1 2 1 312382 ABCG2_32656 5.21654 5.21654 2.73368 2.73368 11.386 11.386 5.21654 2.73368 11.386 2 361969;24330 FGA_8632;EGR1_8533 14.6651585 14.6651585 19.678981831640694 11.3575095 11.3575095 15.798873377022186 21.77644 21.77644 24.147215744909396 28.5803;0.750017 22.529;0.186019 38.8511;4.70178 0 Exp 4,1(0.34);Hill,1(0.34);Linear,1(0.34) 2.140309789838622 7.267617464065552 1.5074360370635986 4.21828556060791 1.5552574499865557 1.541895866394043 -5.397638826498728 28.42887682649873 -5.35754773498325 22.323347068316583 -2.1666514505793835 38.79257145057939 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0051247 7 positive regulation of protein metabolic process 428 454 31 31 25 27 21 21 141 433 1952 0.054948 0.96623 0.11091 4.63 246273;24825;25106;25513;25493;24516;63868;24471;25675;290556;29455;299626;25112;25661;361969;24890;29496;24330;25423;114851;29184 trib3;tf;rgn;pik3r1;nfkbia;jun;hspd1;hspb1;hmgcr;gnl3;gdf15;gadd45b;gadd45a;fn1;fga;esr1;erbb3;egr1;ctsc;cdkn1a;cd36 TRIB3_10079;TF_10003;RGN_9699;PIK3R1_32562;NFKBIA_9307;JUN_8938;HSPD1_8849;HSPB1_8847;HMGCR_8810;GNL3_8735;GDF15_33113;GADD45B_8679;GADD45A_8678;FN1_8655;FGA_8632;ESR1_33192;ERBB3_8571;EGR1_8533;CTSC_32456;CDKN1A_8271;CD36_8243 51.682172761904766 48.1296 0.520151 37.92518141609563 54.19616990433895 34.72638737624796 35.808576571428574 31.0499 0.160202 28.518934719842974 38.64292207801692 28.21995036740102 79.55182714285715 89.8047 2.88499 57.097409251822 79.87473590288863 44.09225986822377 108.064;45.1539;77.4407;18.7324;0.520151;16.4324;42.2579;89.1011;1.63089;87.6357;105.149;106.367;102.919;59.5777;28.5803;23.3972;60.9984;0.750017;56.2386;6.24967;48.1296 83.8836;28.132;58.7732;11.6701;0.160202;10.5224;23.9469;60.3265;0.663137;54.41;85.3487;52.7132;89.5012;31.0499;22.529;18.3088;41.6036;0.186019;38.2681;2.44025;37.5433 143.428;61.5341;89.8047;41.5978;2.88499;39.929;102.383;106.138;7.6286;238.963;125.652;109.434;115.437;105.243;38.8511;31.9156;113.972;4.70178;102.888;19.0606;69.1421 7 14 7 24825;25106;63868;290556;299626;29496;29184 TF_10003;RGN_9699;HSPD1_8849;GNL3_8735;GADD45B_8679;ERBB3_8571;CD36_8243 66.85474285714285 60.9984 24.37891205822887 42.44602857142858 41.6036 13.45971491485043 112.17612857142856 102.383 59.29949978203061 45.1539;77.4407;42.2579;87.6357;106.367;60.9984;48.1296 28.132;58.7732;23.9469;54.41;52.7132;41.6036;37.5433 61.5341;89.8047;102.383;238.963;109.434;113.972;69.1421 14 246273;25513;25493;24516;24471;25675;29455;25112;25661;361969;24890;24330;25423;114851 TRIB3_10079;PIK3R1_32562;NFKBIA_9307;JUN_8938;HSPB1_8847;HMGCR_8810;GDF15_33113;GADD45A_8678;FN1_8655;FGA_8632;ESR1_33192;EGR1_8533;CTSC_32456;CDKN1A_8271 44.09588771428571 25.988750000000003 41.863539594020494 32.48985057142857 20.4189 33.646377816832874 63.239676428571435 40.763400000000004 50.328211892713824 108.064;18.7324;0.520151;16.4324;89.1011;1.63089;105.149;102.919;59.5777;28.5803;23.3972;0.750017;56.2386;6.24967 83.8836;11.6701;0.160202;10.5224;60.3265;0.663137;85.3487;89.5012;31.0499;22.529;18.3088;0.186019;38.2681;2.44025 143.428;41.5978;2.88499;39.929;106.138;7.6286;125.652;115.437;105.243;38.8511;31.9156;4.70178;102.888;19.0606 0 Exp 2,4(0.2);Exp 3,1(0.05);Exp 4,3(0.15);Hill,1(0.05);Linear,2(0.1);Poly 2,8(0.39);Power,2(0.1) 1.864098667381122 40.46270740032196 1.522104263305664 4.21828556060791 0.6079244453173029 1.7198865413665771 35.46130473404696 67.90304078976257 23.61082670939799 48.00632643345913 55.130861820504826 103.97279246520947 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0071372 7 cellular response to follicle-stimulating hormone stimulus 17 19 4 4 4 4 4 4 158 15 2370 0.99452 0.028823 0.028823 21.05 24825;83516;29441;24330 tf;ppargc1a;por;egr1 TF_10003;PPARGC1A_33189;POR_9531;EGR1_8533 25.18867925 27.4254 0.750017 22.02199357909244 25.256024785299886 22.158218963262794 15.77665725 17.394305 0.186019 13.656941170561716 15.818448346457007 13.74901574747364 56.800470000000004 70.3848 4.70178 35.877187364650915 55.96403441203538 35.661998399919746 0.0 0.750017 0.5 6.5957085 45.1539;42.4094;12.4414;0.750017 28.132;26.2988;8.48981;0.186019 61.5341;81.7305;79.2355;4.70178 1 3 1 24825 TF_10003 45.1539 45.1539 28.132 28.132 61.5341 61.5341 45.1539 28.132 61.5341 3 83516;29441;24330 PPARGC1A_33189;POR_9531;EGR1_8533 18.533605666666666 12.4414 21.487491137843342 11.658209666666666 8.48981 13.341604109862141 55.22259333333333 79.2355 43.77008900089345 42.4094;12.4414;0.750017 26.2988;8.48981;0.186019 81.7305;79.2355;4.70178 0 Exp 2,1(0.25);Hill,1(0.25);Poly 2,2(0.5) 2.2785844589307795 9.79230797290802 1.7576230764389038 4.21828556060791 1.1838034468541532 1.908199667930603 3.6071255424894026 46.7702329575106 2.3928549028495194 29.160459597150485 21.640826382642118 91.96011361735789 DOWN 0.25 0.75 0.0 GO:0046890 6 regulation of lipid biosynthetic process 73 78 13 13 11 12 10 10 152 68 2317 0.99083 0.023937 0.029411 12.82 246273;25357;293615;25106;83516;29441;24330;25428;25146;25287 trib3;thrsp;sirt3;rgn;ppargc1a;por;egr1;cyp7a1;cyp17a1;acadl TRIB3_10079;THRSP_33314;SIRT3_9828;RGN_9699;PPARGC1A_33189;POR_9531;EGR1_8533;CYP7A1_8430;CYP17A1_32365;ACADL_32776 36.4592277 32.84655 0.750017 34.96406500481223 35.6353497202923 35.51286569015229 26.5844692 25.3477 0.186019 27.413327600253947 25.972689324648645 27.606252383222568 60.366265 62.92115 4.70178 43.005792709671425 61.031938254424055 43.87741083293123 2.5 9.08134 6.5 46.050799999999995 108.064;32.2053;2.38018;77.4407;42.4094;12.4414;0.750017;5.72128;49.6922;33.4878 83.8836;24.3966;0.56209;58.7732;26.2988;8.48981;0.186019;0.985273;35.6654;26.6039 143.428;46.6068;8.82917;89.8047;81.7305;79.2355;4.70178;22.3625;81.6409;45.3228 4 6 4 293615;25106;25146;25287 SIRT3_9828;RGN_9699;CYP17A1_32365;ACADL_32776 40.75022 41.59 31.364273958379258 30.4011475 31.13465 24.065702832808043 56.3993925 63.48185 37.142362338048606 2.38018;77.4407;49.6922;33.4878 0.56209;58.7732;35.6654;26.6039 8.82917;89.8047;81.6409;45.3228 6 246273;25357;83516;29441;24330;25428 TRIB3_10079;THRSP_33314;PPARGC1A_33189;POR_9531;EGR1_8533;CYP7A1_8430 33.598566166666664 22.32335 39.82077037429944 24.040017000000002 16.443205 31.396901304387526 63.01084666666667 62.92115 49.803436500421 108.064;32.2053;42.4094;12.4414;0.750017;5.72128 83.8836;24.3966;26.2988;8.48981;0.186019;0.985273 143.428;46.6068;81.7305;79.2355;4.70178;22.3625 0 Exp 2,3(0.3);Hill,3(0.3);Linear,1(0.1);Poly 2,3(0.3) 2.253347810430982 24.279202938079834 1.5209722518920898 4.560328960418701 1.093635818795794 1.8983157277107239 14.78827569201502 58.130179707984965 9.593512721612584 43.575425678387425 33.710998521449284 87.02153147855071 DOWN 0.4 0.6 0.0 GO:0043408 7 regulation of MAPK cascade 190 203 15 15 15 13 13 13 149 190 2195 0.58391 0.53453 1.0 6.4 246273;24825;293615;24516;25675;29455;299626;25112;25661;361969;24890;116663;29184 trib3;tf;sirt3;jun;hmgcr;gdf15;gadd45b;gadd45a;fn1;fga;esr1;dusp6;cd36 TRIB3_10079;TF_10003;SIRT3_9828;JUN_8938;HMGCR_8810;GDF15_33113;GADD45B_8679;GADD45A_8678;FN1_8655;FGA_8632;ESR1_33192;DUSP6_8506;CD36_8243 54.628813076923066 48.1296 1.63089 40.08822441131174 58.86225612798295 35.67362138577901 38.44960207692308 31.0499 0.56209 31.008403214787883 42.950602648388596 30.2914338057443 76.17905153846154 69.1421 7.6286 48.210393274984774 82.44332869816581 42.75452263044485 9.5 104.03399999999999 108.064;45.1539;2.38018;16.4324;1.63089;105.149;106.367;102.919;59.5777;28.5803;23.3972;62.3934;48.1296 83.8836;28.132;0.56209;10.5224;0.663137;85.3487;52.7132;89.5012;31.0499;22.529;18.3088;39.0875;37.5433 143.428;61.5341;8.82917;39.929;7.6286;125.652;109.434;115.437;105.243;38.8511;31.9156;133.304;69.1421 4 9 4 24825;293615;299626;29184 TF_10003;SIRT3_9828;GADD45B_8679;CD36_8243 50.507670000000005 46.64175 42.70377856773644 29.7376475 32.837650000000004 21.92863791910079 62.2348425 65.3381 41.34459888187604 45.1539;2.38018;106.367;48.1296 28.132;0.56209;52.7132;37.5433 61.5341;8.82917;109.434;69.1421 9 246273;24516;25675;29455;25112;25661;361969;24890;116663 TRIB3_10079;JUN_8938;HMGCR_8810;GDF15_33113;GADD45A_8678;FN1_8655;FGA_8632;ESR1_33192;DUSP6_8506 56.46043222222222 59.5777 41.40625252641617 42.321581888888886 31.0499 34.74394676959825 82.37647777777778 105.243 52.00882133815805 108.064;16.4324;1.63089;105.149;102.919;59.5777;28.5803;23.3972;62.3934 83.8836;10.5224;0.663137;85.3487;89.5012;31.0499;22.529;18.3088;39.0875 143.428;39.929;7.6286;125.652;115.437;105.243;38.8511;31.9156;133.304 0 Exp 2,3(0.24);Exp 4,1(0.08);Hill,1(0.08);Linear,1(0.08);Poly 2,5(0.39);Power,2(0.16) 1.8125154818333407 23.924285531044006 1.5209722518920898 2.6703107357025146 0.3546509256681757 1.7792335748672485 32.836606048592955 76.4210201052532 21.59324207600669 55.30596207783947 49.97158322092662 102.38651985599648 DOWN 0.3076923076923077 0.6923076923076923 0.0 GO:0010941 5 regulation of cell death 479 511 48 48 42 42 36 36 126 475 1910 0.79296 0.26801 0.47835 7.05 79426;24794;25106;83516;29441;25513;81819;25591;24314;24567;24516;192235;63868;24471;24464;25675;29328;299626;25112;289388;294515;314322;25661;361969;24360;24890;29496;24330;116663;140942;25423;114851;29184;246142;50559;170465 zfp36;serpina3c;rgn;ppargc1a;por;pik3r1;pax8;parp1;nqo1;mt1;jun;hyou1;hspd1;hspb1;hp;hmgcr;gpx4;gadd45b;gadd45a;g0s2;foxo3;fos;fn1;fga;fabp1;esr1;erbb3;egr1;dusp6;ddit4;ctsc;cdkn1a;cd36;bmf;acot1;acaa2 ZFP36_10204;SERPINA3C_32925;RGN_9699;PPARGC1A_33189;POR_9531;PIK3R1_32562;PAX8_9432;PARP1_9425;NQO1_33055;MT1A_9255;JUN_8938;HYOU1_8857;HSPD1_8849;HSPB1_8847;HP_8823;HMGCR_8810;GPX4_32827;GADD45B_8679;GADD45A_8678;G0S2_32729;FOXO3_8662;FOS_8657;FN1_8655;FGA_8632;FABP1_33091;ESR1_33192;ERBB3_8571;EGR1_8533;DUSP6_8506;DDIT4_8450;CTSC_32456;CDKN1A_8271;CD36_8243;BMF_8152;ACOT1_7968;ACAA2_7955 43.19213086111116 41.228049999999996 1.28141E-12 30.929846322117232 46.32786576940768 29.230705230585592 29.991068000000034 26.6658 1.28141E-12 21.944135860417727 33.1689433477351 22.345932175393113 72.83447777777782 69.78565 1.28142E-12 53.6352624807158 73.72828507616998 43.333680191620836 24.5 58.2354 0.348134;29.766;77.4407;42.4094;12.4414;18.7324;56.8931;26.9741;87.2765;12.9315;16.4324;40.1982;42.2579;89.1011;64.9285;1.63089;45.9204;106.367;102.919;46.3784;13.1992;1.28141E-12;59.5777;28.5803;33.8478;23.3972;60.9984;0.750017;62.3934;87.5421;56.2386;6.24967;48.1296;94.8767;31.2018;26.5872 0.118102;23.347;58.7732;26.2988;8.48981;11.6701;45.1162;21.799;60.6992;8.91033;10.5224;29.3844;23.9469;60.3265;41.6103;0.663137;34.2198;52.7132;89.5012;33.7914;5.6804;1.28141E-12;31.0499;22.529;26.4736;18.3088;41.6036;0.186019;39.0875;53.2453;38.2681;2.44025;37.5433;73.1342;26.858;21.3695 1.15962;40.8256;89.8047;81.7305;79.2355;41.5978;81.5688;35.2797;197.117;23.4636;39.929;62.3571;102.383;106.138;136.455;7.6286;70.4292;109.434;115.437;73.6529;32.7581;1.28142E-12;105.243;38.8511;46.9257;31.9156;113.972;4.70178;133.304;245.492;102.888;19.0606;69.1421;109.848;37.2719;35.0407 14 22 14 25106;81819;25591;24314;63868;29328;299626;289388;24360;29496;29184;246142;50559;170465 RGN_9699;PAX8_9432;PARP1_9425;NQO1_33055;HSPD1_8849;GPX4_32827;GADD45B_8679;G0S2_32729;FABP1_33091;ERBB3_8571;CD36_8243;BMF_8152;ACOT1_7968;ACAA2_7955 56.08211428571428 47.254000000000005 25.973494161189013 39.860078571428566 35.881550000000004 16.263706500585855 83.70497857142857 77.61085 43.16853500896545 77.4407;56.8931;26.9741;87.2765;42.2579;45.9204;106.367;46.3784;33.8478;60.9984;48.1296;94.8767;31.2018;26.5872 58.7732;45.1162;21.799;60.6992;23.9469;34.2198;52.7132;33.7914;26.4736;41.6036;37.5433;73.1342;26.858;21.3695 89.8047;81.5688;35.2797;197.117;102.383;70.4292;109.434;73.6529;46.9257;113.972;69.1421;109.848;37.2719;35.0407 22 79426;24794;83516;29441;25513;24567;24516;192235;24471;24464;25675;25112;294515;314322;25661;361969;24890;24330;116663;140942;25423;114851 ZFP36_10204;SERPINA3C_32925;PPARGC1A_33189;POR_9531;PIK3R1_32562;MT1A_9255;JUN_8938;HYOU1_8857;HSPB1_8847;HP_8823;HMGCR_8810;GADD45A_8678;FOXO3_8662;FOS_8657;FN1_8655;FGA_8632;ESR1_33192;EGR1_8533;DUSP6_8506;DDIT4_8450;CTSC_32456;CDKN1A_8271 34.98941413636369 25.988750000000003 31.55227243520396 23.710788545454605 20.4189 23.07770240947833 65.91688636363642 41.2117 59.2625475437977 0.348134;29.766;42.4094;12.4414;18.7324;12.9315;16.4324;40.1982;89.1011;64.9285;1.63089;102.919;13.1992;1.28141E-12;59.5777;28.5803;23.3972;0.750017;62.3934;87.5421;56.2386;6.24967 0.118102;23.347;26.2988;8.48981;11.6701;8.91033;10.5224;29.3844;60.3265;41.6103;0.663137;89.5012;5.6804;1.28141E-12;31.0499;22.529;18.3088;0.186019;39.0875;53.2453;38.2681;2.44025 1.15962;40.8256;81.7305;79.2355;41.5978;23.4636;39.929;62.3571;106.138;136.455;7.6286;115.437;32.7581;1.28142E-12;105.243;38.8511;31.9156;4.70178;133.304;245.492;102.888;19.0606 0 Exp 2,14(0.39);Exp 3,1(0.03);Exp 4,3(0.09);Hill,3(0.09);Linear,5(0.14);Poly 2,8(0.23);Power,2(0.06) 2.1628792789859284 411.32183027267456 1.522104263305664 344.14306640625 57.03953279629319 1.7549105286598206 33.088381062552834 53.29588065966944 22.822650285596907 37.15948571440316 55.31362536741064 90.35533018814498 DOWN 0.3888888888888889 0.6111111111111112 0.0 GO:0002376 2 immune system process 352 390 27 26 18 21 15 15 147 375 2010 0.014099 0.99288 0.024248 3.85 29573;85253;25513;25493;24516;63868;24464;246186;361969;308441;24330;140942;25423;29184;313421 slc37a4;plg;pik3r1;nfkbia;jun;hspd1;hp;fgl1;fga;exosc5;egr1;ddit4;ctsc;cd36;c8b SLC37A4_9871;PLG_9501;PIK3R1_32562;NFKBIA_9307;JUN_8938;HSPD1_8849;HP_8823;FGL1_8640;FGA_8632;EXOSC5_32543;EGR1_8533;DDIT4_8450;CTSC_32456;CD36_8243;C8B_8181 36.8923112 39.7166 0.520151 25.647984298949734 38.48590341901116 23.016831778909513 24.51763473333333 22.6911 0.160202 16.500637573097144 25.75959062284253 15.14339479889725 74.360078 60.0334 2.88499 64.64273345023688 73.60330924783673 53.21873097995081 39.7166;70.7857;18.7324;0.520151;16.4324;42.2579;64.9285;15.4757;28.5803;41.9329;0.750017;87.5421;56.2386;48.1296;21.3618 22.6911;46.2356;11.6701;0.160202;10.5224;23.9469;41.6103;10.2138;22.529;31.7336;0.186019;53.2453;38.2681;37.5433;17.2088 60.0334;150.579;41.5978;2.88499;39.929;102.383;136.455;30.4106;38.8511;62.1373;4.70178;245.492;102.888;69.1421;27.9161 3 12 3 63868;308441;29184 HSPD1_8849;EXOSC5_32543;CD36_8243 44.1068 42.2579 3.487634747217576 31.0746 31.7336 6.822113601370173 77.88746666666667 69.1421 21.500934182572955 42.2579;41.9329;48.1296 23.9469;31.7336;37.5433 102.383;62.1373;69.1421 12 29573;85253;25513;25493;24516;24464;246186;361969;24330;140942;25423;313421 SLC37A4_9871;PLG_9501;PIK3R1_32562;NFKBIA_9307;JUN_8938;HP_8823;FGL1_8640;FGA_8632;EGR1_8533;DDIT4_8450;CTSC_32456;C8B_8181 35.088689 24.971049999999998 28.58791385709645 22.87839341666667 19.8689 17.983541391621603 73.47823083333333 40.763400000000004 72.3189414543716 39.7166;70.7857;18.7324;0.520151;16.4324;64.9285;15.4757;28.5803;0.750017;87.5421;56.2386;21.3618 22.6911;46.2356;11.6701;0.160202;10.5224;41.6103;10.2138;22.529;0.186019;53.2453;38.2681;17.2088 60.0334;150.579;41.5978;2.88499;39.929;136.455;30.4106;38.8511;4.70178;245.492;102.888;27.9161 0 Exp 2,5(0.34);Exp 3,1(0.07);Exp 4,1(0.07);Hill,1(0.07);Linear,3(0.2);Poly 2,4(0.27) 1.858036992949703 29.104113340377808 1.511321783065796 4.21828556060791 0.70809781373814 1.6672165393829346 23.91264030232677 49.87198209767322 16.167159982405146 32.86810948426152 41.64634126613726 107.07381473386278 DOWN 0.2 0.8 0.0 GO:0009266 4 response to temperature stimulus 80 87 16 16 12 15 11 11 151 76 2309 0.99213 0.020069 0.023038 12.64 83516;24651;24539;63868;24464;314322;113936;114851;24158;25287;25303 ppargc1a;pklr;lpl;hspd1;hp;fos;cpb2;cdkn1a;acadm;acadl;abcc2 PPARGC1A_33189;PKLR_9489;LPL_32544;HSPD1_8849;HP_8823;FOS_8657;CPB2_8369;CDKN1A_8271;ACADM_7957;ACADL_32776;ABCC2_32541 33.6736881818183 33.4878 1.28141E-12 23.385741850215652 38.79189110639146 25.981035595071027 22.564414545454664 23.9469 1.28141E-12 15.36566124842083 25.250110504328788 17.35098419068563 64.4431272727274 45.3228 1.28142E-12 51.00929728459476 78.86566797638552 55.70283252270548 3.5 24.46395 7.5 44.320499999999996 42.4094;23.0963;74.2041;42.2579;64.9285;1.28141E-12;25.8316;6.24967;11.7137;33.4878;46.2316 26.2988;17.4625;49.8682;23.9469;41.6103;1.28141E-12;20.4374;2.44025;8.36151;26.6039;31.1788 81.7305;32.9443;155.425;102.383;136.455;1.28142E-12;34.8042;19.0606;18.9642;45.3228;81.7848 4 7 4 24539;63868;24158;25287 LPL_32544;HSPD1_8849;ACADM_7957;ACADL_32776 40.415875 37.87285 25.92842891298725 27.1951275 25.275399999999998 17.12380308785673 80.52375 73.8529 60.873390845891485 74.2041;42.2579;11.7137;33.4878 49.8682;23.9469;8.36151;26.6039 155.425;102.383;18.9642;45.3228 7 83516;24651;24464;314322;113936;114851;25303 PPARGC1A_33189;PKLR_9489;HP_8823;FOS_8657;CPB2_8369;CDKN1A_8271;ABCC2_32541 29.82101000000018 25.8316 22.972261188181296 19.918292857143037 20.4374 14.980953628091083 55.25420000000018 34.8042 47.04142599046764 42.4094;23.0963;64.9285;1.28141E-12;25.8316;6.24967;46.2316 26.2988;17.4625;41.6103;1.28141E-12;20.4374;2.44025;31.1788 81.7305;32.9443;136.455;1.28142E-12;34.8042;19.0606;81.7848 0 Exp 2,7(0.64);Exp 3,1(0.1);Exp 4,1(0.1);Hill,1(0.1);Poly 2,1(0.1) 1.8206933171695898 20.32037627696991 1.522104263305664 2.6967689990997314 0.3516152250760403 1.7576230764389038 19.853597902172574 47.49377846146401 13.483889026112571 31.644940064796756 34.29855892464713 94.58769562080766 DOWN 0.36363636363636365 0.6363636363636364 0.0 GO:2001238 8 positive regulation of extrinsic apoptotic signaling pathway 16 17 1 1 1 1 1 1 161 16 2369 0.705 0.67399 1.0 5.88 289388 g0s2 G0S2_32729 46.3784 46.3784 46.3784 46.3784 33.7914 33.7914 33.7914 33.7914 73.6529 73.6529 73.6529 73.6529 0.0 46.3784 46.3784 33.7914 73.6529 1 0 1 289388 G0S2_32729 46.3784 46.3784 33.7914 33.7914 73.6529 73.6529 46.3784 33.7914 73.6529 0 0 Linear,1(1) 2.285230875015259 2.285230875015259 2.285230875015259 2.285230875015259 0.0 2.285230875015259 46.3784 46.3784 33.7914 33.7914 73.6529 73.6529 UP 1.0 0.0 0.0 GO:0015980 4 energy derivation by oxidation of organic compounds 29 31 5 5 5 4 4 4 158 27 2358 0.95673 0.13045 0.13045 12.9 29573;293615;192280;24158 slc37a4;sirt3;ppp1r3b;acadm SLC37A4_9871;SIRT3_9828;PPP1R3B_9545;ACADM_7957 22.487895 23.9274 2.38018 18.290632968528815 26.86414493408366 17.67731668013636 14.668375000000001 15.526305 0.56209 12.337619580449868 17.664797553028215 12.105281758300759 35.3627925 36.2943 8.82917 25.265735307306848 41.49258876588879 24.349360221322776 0.5 7.046939999999999 2.5 37.92885 39.7166;2.38018;36.1411;11.7137 22.6911;0.56209;27.0588;8.36151 60.0334;8.82917;53.6244;18.9642 2 2 2 293615;24158 SIRT3_9828;ACADM_7957 7.046939999999999 7.046939999999999 6.599795284340264 4.4618 4.4618 5.515022771321984 13.896685000000002 13.896685000000002 7.1665484405290965 2.38018;11.7137 0.56209;8.36151 8.82917;18.9642 2 29573;192280 SLC37A4_9871;PPP1R3B_9545 37.92885 37.92885 2.5282602961326943 24.87495 24.87495 3.088430288188487 56.828900000000004 56.828900000000004 4.531847360624452 39.7166;36.1411 22.6911;27.0588 60.0334;53.6244 0 Exp 2,1(0.25);Hill,1(0.25);Poly 2,2(0.5) 1.740016223684201 6.9875171184539795 1.5209722518920898 1.893584966659546 0.17620738541935388 1.7864799499511719 4.563074690841759 40.412715309158244 2.57750781115913 26.759242188840872 10.602371898839298 60.123213101160715 CONFLICT 0.5 0.5 0.0 GO:0046165 5 alcohol biosynthetic process 38 41 13 13 8 9 5 5 157 36 2349 0.95753 0.11539 0.1815 12.2 293688;29540;25675;25315;298541 tm7sf2;hsd17b7;hmgcr;ephx1;dhdds TM7SF2_10031;HSD17B7_8834;HMGCR_8810;EPHX1_8567;DHDDS_8467 29.067316800000004 12.4747 0.977494 35.384260553155286 30.13781358537378 34.59494996153284 19.145713800000003 7.00435 0.322682 23.30460311997847 19.280044791440954 22.533465304569702 63.604704000000005 23.684 5.49472 85.94979475955763 67.11679842253521 87.22324298952753 1.5 7.052795 3.5 65.12675 82.3097;0.977494;1.63089;12.4747;47.9438 51.1696;0.322682;0.663137;7.00435;36.5688 209.842;5.49472;7.6286;23.684;71.3742 2 3 2 25315;298541 EPHX1_8567;DHDDS_8467 30.20925 30.20925 25.080441132583775 21.786575000000003 21.786575000000003 20.90522307705062 47.5291 47.5291 33.72206381614271 12.4747;47.9438 7.00435;36.5688 23.684;71.3742 3 293688;29540;25675 TM7SF2_10031;HSD17B7_8834;HMGCR_8810 28.306028 1.63089 46.769692897173194 17.385139666666667 0.663137 29.25869609898374 74.32177333333334 7.6286 117.36880862393609 82.3097;0.977494;1.63089 51.1696;0.322682;0.663137 209.842;5.49472;7.6286 0 Exp 2,1(0.2);Exp 4,2(0.4);Hill,1(0.2);Linear,1(0.2) 1.8869856600995936 9.526325345039368 1.703133225440979 2.4453113079071045 0.31176330014849135 1.7512425184249878 -1.9483550767244573 60.082988676724455 -1.2816714918508119 39.57309909185081 -11.733612823934202 138.9430208239342 DOWN 0.4 0.6 0.0 GO:0048522 5 positive regulation of cellular process 1060 1140 86 85 65 73 57 57 105 1083 1302 0.0067699 0.99581 0.011383 5.0 79426;246273;24825;360268;362895;29482;293615;24794;25106;83516;29441;303612;85253;25513;81819;25591;24314;25493;100359982;24539;58954;24516;25685;494344;65164;63868;24471;24464;25675;81869;290556;24957;29455;299626;25112;289388;294515;314322;25661;361969;24360;24890;29496;116636;24330;116663;140942;65210;25146;25423;113936;25695;114851;29184;246142;25698;25373 zfp36;trib3;tf;sult1e1;stac3;slc1a2;sirt3;serpina3c;rgn;ppargc1a;por;polg2;plg;pik3r1;pax8;parp1;nqo1;nfkbia;mpc2;lpl;klf6;jun;igfbp1;ier2;htra1;hspd1;hspb1;hp;hmgcr;gstm7;gnl3;glul;gdf15;gadd45b;gadd45a;g0s2;foxo3;fos;fn1;fga;fabp1;esr1;erbb3;eif4ebp1;egr1;dusp6;ddit4;cyp2j4;cyp17a1;ctsc;cpb2;cebpd;cdkn1a;cd36;bmf;ass1;ahsg ZFP36_10204;TRIB3_10079;TF_10003;SULT1E1_32446;STAC3_9953;SLC1A2_33059;SIRT3_9828;SERPINA3C_32925;RGN_9699;PPARGC1A_33189;POR_9531;POLG2_9521;PLG_9501;PIK3R1_32562;PAX8_9432;PARP1_9425;NQO1_33055;NFKBIA_9307;MPC2_33219;LPL_32544;KLF6_8969;JUN_8938;IGFBP1_32306;IER2_32643;HTRA1_8856;HSPD1_8849;HSPB1_8847;HP_8823;HMGCR_8810;GSTM7_8761;GNL3_8735;GLUL_32832;GDF15_33113;GADD45B_8679;GADD45A_8678;G0S2_32729;FOXO3_8662;FOS_8657;FN1_8655;FGA_8632;FABP1_33091;ESR1_33192;ERBB3_8571;EIF4EBP1_8550;EGR1_8533;DUSP6_8506;DDIT4_8450;CYP2J4_32580;CYP17A1_32365;CTSC_32456;CPB2_8369;CEBPD_8283;CDKN1A_8271;CD36_8243;BMF_8152;ASS1_33159;AHSG_8003 45.01202066666668 45.1539 1.28141E-12 31.538862612007897 48.07589638820533 30.346454822553678 31.106878319298268 31.0499 1.28141E-12 22.498753192901233 33.8067108146516 22.831847570371423 76.85501140350881 73.6529 1.28142E-12 56.46432034600418 78.24454239848063 47.63675471380321 56.0 108.064 0.348134;108.064;45.1539;50.1846;63.2393;13.3235;2.38018;29.766;77.4407;42.4094;12.4414;63.7758;70.7857;18.7324;56.8931;26.9741;87.2765;0.520151;46.8463;74.2041;18.9476;16.4324;49.0259;49.6814;33.1323;42.2579;89.1011;64.9285;1.63089;42.3152;87.6357;26.4669;105.149;106.367;102.919;46.3784;13.1992;1.28141E-12;59.5777;28.5803;33.8478;23.3972;60.9984;83.9001;0.750017;62.3934;87.5421;17.8395;49.6922;56.2386;25.8316;0.306936;6.24967;48.1296;94.8767;26.8037;12.402 0.118102;83.8836;28.132;36.5009;42.7031;9.10952;0.56209;23.347;58.7732;26.2988;8.48981;40.9553;46.2356;11.6701;45.1162;21.799;60.6992;0.160202;35.8494;49.8682;11.6941;10.5224;32.6883;33.4626;25.6145;23.9469;60.3265;41.6103;0.663137;31.4035;54.41;21.0456;85.3487;52.7132;89.5012;33.7914;5.6804;1.28141E-12;31.0499;22.529;26.4736;18.3088;41.6036;42.4185;0.186019;39.0875;53.2453;14.6501;35.6654;38.2681;20.4374;0.0732342;2.44025;37.5433;73.1342;20.9825;10.3013 1.15962;143.428;61.5341;80.9788;121.52;24.6773;8.82917;40.8256;89.8047;81.7305;79.2355;132.567;150.579;41.5978;81.5688;35.2797;197.117;2.88499;69.127;155.425;45.5481;39.929;89.1623;89.4404;46.6629;102.383;106.138;136.455;7.6286;64.5991;238.963;35.4303;125.652;109.434;115.437;73.6529;32.7581;1.28142E-12;105.243;38.8511;46.9257;31.9156;113.972;107.32;4.70178;133.304;245.492;22.6149;81.6409;102.888;34.8042;1.73689;19.0606;69.1421;109.848;36.7081;15.4235 21 36 21 24825;360268;293615;25106;81819;25591;24314;100359982;24539;63868;81869;290556;299626;289388;24360;29496;116636;65210;25146;29184;246142 TF_10003;SULT1E1_32446;SIRT3_9828;RGN_9699;PAX8_9432;PARP1_9425;NQO1_33055;MPC2_33219;LPL_32544;HSPD1_8849;GSTM7_8761;GNL3_8735;GADD45B_8679;G0S2_32729;FABP1_33091;ERBB3_8571;EIF4EBP1_8550;CYP2J4_32580;CYP17A1_32365;CD36_8243;BMF_8152 56.26628476190476 49.6922 26.543619712512406 38.335899523809516 36.5009 16.73224693449165 91.43618428571429 81.5688 54.0813094531492 45.1539;50.1846;2.38018;77.4407;56.8931;26.9741;87.2765;46.8463;74.2041;42.2579;42.3152;87.6357;106.367;46.3784;33.8478;60.9984;83.9001;17.8395;49.6922;48.1296;94.8767 28.132;36.5009;0.56209;58.7732;45.1162;21.799;60.6992;35.8494;49.8682;23.9469;31.4035;54.41;52.7132;33.7914;26.4736;41.6036;42.4185;14.6501;35.6654;37.5433;73.1342 61.5341;80.9788;8.82917;89.8047;81.5688;35.2797;197.117;69.127;155.425;102.383;64.5991;238.963;109.434;73.6529;46.9257;113.972;107.32;22.6149;81.6409;69.1421;109.848 36 79426;246273;362895;29482;24794;83516;29441;303612;85253;25513;25493;58954;24516;25685;494344;65164;24471;24464;25675;24957;29455;25112;294515;314322;25661;361969;24890;24330;116663;140942;25423;113936;25695;114851;25698;25373 ZFP36_10204;TRIB3_10079;STAC3_9953;SLC1A2_33059;SERPINA3C_32925;PPARGC1A_33189;POR_9531;POLG2_9521;PLG_9501;PIK3R1_32562;NFKBIA_9307;KLF6_8969;JUN_8938;IGFBP1_32306;IER2_32643;HTRA1_8856;HSPB1_8847;HP_8823;HMGCR_8810;GLUL_32832;GDF15_33113;GADD45A_8678;FOXO3_8662;FOS_8657;FN1_8655;FGA_8632;ESR1_33192;EGR1_8533;DUSP6_8506;DDIT4_8450;CTSC_32456;CPB2_8369;CEBPD_8283;CDKN1A_8271;ASS1_33159;AHSG_8003 38.44703327777782 27.692 32.68923943416337 26.88994928333337 21.787300000000002 24.500666478836113 68.34932722222226 43.57295 56.81429077244062 0.348134;108.064;63.2393;13.3235;29.766;42.4094;12.4414;63.7758;70.7857;18.7324;0.520151;18.9476;16.4324;49.0259;49.6814;33.1323;89.1011;64.9285;1.63089;26.4669;105.149;102.919;13.1992;1.28141E-12;59.5777;28.5803;23.3972;0.750017;62.3934;87.5421;56.2386;25.8316;0.306936;6.24967;26.8037;12.402 0.118102;83.8836;42.7031;9.10952;23.347;26.2988;8.48981;40.9553;46.2356;11.6701;0.160202;11.6941;10.5224;32.6883;33.4626;25.6145;60.3265;41.6103;0.663137;21.0456;85.3487;89.5012;5.6804;1.28141E-12;31.0499;22.529;18.3088;0.186019;39.0875;53.2453;38.2681;20.4374;0.0732342;2.44025;20.9825;10.3013 1.15962;143.428;121.52;24.6773;40.8256;81.7305;79.2355;132.567;150.579;41.5978;2.88499;45.5481;39.929;89.1623;89.4404;46.6629;106.138;136.455;7.6286;35.4303;125.652;115.437;32.7581;1.28142E-12;105.243;38.8511;31.9156;4.70178;133.304;245.492;102.888;34.8042;1.73689;19.0606;36.7081;15.4235 0 Exp 2,20(0.36);Exp 3,2(0.04);Exp 4,4(0.08);Hill,5(0.09);Linear,12(0.22);Poly 2,12(0.22);Power,2(0.04) 1.877876998271718 110.76150405406952 1.5209722518920898 4.21828556060791 0.6042629265685733 1.7501527070999146 36.824268835878556 53.199772497454845 25.26601430616511 36.94774233243142 62.19640281718691 91.5136199898306 DOWN 0.3684210526315789 0.631578947368421 0.0 GO:0010884 5 positive regulation of lipid storage 9 9 3 3 3 3 3 3 159 6 2379 0.99846 0.01596 0.01596 33.33 298199;24539;29184 plin2;lpl;cd36 PLIN2_9502;LPL_32544;CD36_8243 49.328466666666664 48.1296 25.6517 24.298391868667643 58.55772970844417 19.083850344750694 36.112233333333336 37.5433 20.9252 14.52447162905878 42.035160465237574 10.267461554084019 85.8682 69.1421 33.0375 62.88479033096956 106.44268515620925 56.78238615690656 0.0 25.6517 0.0 25.6517 25.6517;74.2041;48.1296 20.9252;49.8682;37.5433 33.0375;155.425;69.1421 3 0 3 298199;24539;29184 PLIN2_9502;LPL_32544;CD36_8243 49.328466666666664 48.1296 24.298391868667643 36.112233333333336 37.5433 14.52447162905878 85.8682 69.1421 62.88479033096956 25.6517;74.2041;48.1296 20.9252;49.8682;37.5433 33.0375;155.425;69.1421 0 0 Exp 2,3(1) 2.108060609241951 6.479438781738281 1.559399127960205 2.6703107357025146 0.5608875235814079 2.2497289180755615 21.832247817616132 76.82468551571719 19.676246427779965 52.54822023888671 14.707360773983865 157.02903922601615 UP 1.0 0.0 0.0 GO:0060539 7 diaphragm development 1 1 1 1 1 1 1 1 161 0 2385 1.0 0.063604 0.063604 100.0 25698 ass1 ASS1_33159 26.8037 26.8037 26.8037 26.8037 20.9825 20.9825 20.9825 20.9825 36.7081 36.7081 36.7081 36.7081 0.0 26.8037 0.0 26.8037 26.8037 20.9825 36.7081 0 1 0 1 25698 ASS1_33159 26.8037 26.8037 20.9825 20.9825 36.7081 36.7081 26.8037 20.9825 36.7081 0 Exp 2,1(1) 1.8814297914505005 1.8814297914505005 1.8814297914505005 1.8814297914505005 0.0 1.8814297914505005 26.8037 26.8037 20.9825 20.9825 36.7081 36.7081 DOWN 0.0 1.0 0.0 GO:0034622 7 cellular protein-containing complex assembly 125 146 8 7 6 5 4 4 158 142 2243 0.037168 0.98706 0.078046 2.74 297784;298699;29328;361969 rrs1;ppan;gpx4;fga RRS1_9755;PPAN_9534;GPX4_32827;FGA_8632 48.14489999999999 51.804649999999995 28.5803 14.477020681295835 45.472536391486614 15.825983160823634 35.305925 37.79285 22.529 9.345957351131382 33.53577074733956 10.245186823729941 78.09909999999999 84.30165 38.8511 30.126288494823477 72.88161265720734 32.548385822881464 60.39;57.6889;45.9204;28.5803 43.109;41.3659;34.2198;22.529 104.942;98.1741;70.4292;38.8511 3 1 3 297784;298699;29328 RRS1_9755;PPAN_9534;GPX4_32827 54.66643333333334 57.6889 7.6937513349037765 39.5649 41.3659 4.7103258815075355 91.18176666666666 98.1741 18.28805306869303 60.39;57.6889;45.9204 43.109;41.3659;34.2198 104.942;98.1741;70.4292 1 361969 FGA_8632 28.5803 28.5803 22.529 22.529 38.8511 38.8511 28.5803 22.529 38.8511 0 Exp 2,3(0.75);Linear,1(0.25) 1.762890338531529 7.145123839378357 1.541895866394043 2.281954288482666 0.347590844086331 1.660636842250824 33.95741973233011 62.332380267669905 26.14688679589125 44.464963204108756 48.57533727507299 107.62286272492699 UP 0.75 0.25 0.0 GO:0009967 6 positive regulation of signal transduction 363 381 21 21 19 19 17 17 145 364 2021 0.058191 0.96558 0.11082 4.46 24825;29441;25513;25591;24516;25675;81869;29455;299626;25112;289388;361969;24890;29496;25423;29184;246142 tf;por;pik3r1;parp1;jun;hmgcr;gstm7;gdf15;gadd45b;gadd45a;g0s2;fga;esr1;erbb3;ctsc;cd36;bmf TF_10003;POR_9531;PIK3R1_32562;PARP1_9425;JUN_8938;HMGCR_8810;GSTM7_8761;GDF15_33113;GADD45B_8679;GADD45A_8678;G0S2_32729;FGA_8632;ESR1_33192;ERBB3_8571;CTSC_32456;CD36_8243;BMF_8152 49.218499411764704 45.1539 1.63089 34.30836047335265 55.016789508196716 32.80135847129174 35.61302629411765 31.4035 0.663137 26.247518503390364 41.64006626642411 27.20754529655076 71.79979411764707 69.1421 7.6286 35.961951286593674 78.84737359981197 33.48973290796524 45.1539;12.4414;18.7324;26.9741;16.4324;1.63089;42.3152;105.149;106.367;102.919;46.3784;28.5803;23.3972;60.9984;56.2386;48.1296;94.8767 28.132;8.48981;11.6701;21.799;10.5224;0.663137;31.4035;85.3487;52.7132;89.5012;33.7914;22.529;18.3088;41.6036;38.2681;37.5433;73.1342 61.5341;79.2355;41.5978;35.2797;39.929;7.6286;64.5991;125.652;109.434;115.437;73.6529;38.8511;31.9156;113.972;102.888;69.1421;109.848 8 9 8 24825;25591;81869;299626;289388;29496;29184;246142 TF_10003;PARP1_9425;GSTM7_8761;GADD45B_8679;G0S2_32729;ERBB3_8571;CD36_8243;BMF_8152 58.899162499999996 47.254000000000005 27.53675008996096 40.015025 35.66735 16.268629395842968 79.68273749999999 71.39750000000001 28.402256164353165 45.1539;26.9741;42.3152;106.367;46.3784;60.9984;48.1296;94.8767 28.132;21.799;31.4035;52.7132;33.7914;41.6036;37.5433;73.1342 61.5341;35.2797;64.5991;109.434;73.6529;113.972;69.1421;109.848 9 29441;25513;24516;25675;29455;25112;361969;24890;25423 POR_9531;PIK3R1_32562;JUN_8938;HMGCR_8810;GDF15_33113;GADD45A_8678;FGA_8632;ESR1_33192;CTSC_32456 40.61346555555556 23.3972 38.90528235932658 31.700138555555554 18.3088 33.31182329424136 64.79273333333335 41.5978 41.991602553933305 12.4414;18.7324;16.4324;1.63089;105.149;102.919;28.5803;23.3972;56.2386 8.48981;11.6701;10.5224;0.663137;85.3487;89.5012;22.529;18.3088;38.2681 79.2355;41.5978;39.929;7.6286;125.652;115.437;38.8511;31.9156;102.888 0 Exp 2,4(0.24);Exp 4,1(0.06);Linear,4(0.24);Poly 2,7(0.42);Power,1(0.06) 1.8271929448242805 31.486917972564697 1.541895866394043 2.6703107357025146 0.3317137093531342 1.7501527070999146 32.909340095066966 65.52765872846247 23.135748014607557 48.09030457362775 54.70456762531954 88.89502060997457 CONFLICT 0.47058823529411764 0.5294117647058824 0.0 GO:0006631 6 fatty acid metabolic process 129 145 49 49 34 44 29 29 133 116 2269 1.0 8.9209E-9 8.9209E-9 20.0 65192;246074;83516;29441;24539;171155;113965;85255;81869;29328;295143;65030;25315;171142;291075;29740;65210;24894;83842;29184;25284;65183;50681;192272;170570;50559;24158;25287;170465 slc27a2;scd;ppargc1a;por;lpl;hadhb;hadh;hacl1;gstm7;gpx4;etfdh;ephx2;ephx1;ehhadh;eci2;eci1;cyp2j4;cyp2a1;crot;cd36;amacr;aldh3a2;acox1;acot2;acot12;acot1;acadm;acadl;acaa2 SLC27A2_9860;SCD1_9787;PPARGC1A_33189;POR_9531;LPL_32544;HADHB_8777;HADH_8776;HACL1_8775;GSTM7_8761;GPX4_32827;ETFDH_8575;EPHX2_33282;EPHX1_8567;EHHADH_8534;ECI2_8521;ECI1_8520;CYP2J4_32580;CYP2A1_32717;CROT_8384;CD36_8243;AMACR_8038;ALDH3A2_8024;ACOX1_7973;ACOT2_7969;ACOT12_32718;ACOT1_7968;ACADM_7957;ACADL_32776;ACAA2_7955 29.402354137931034 26.5872 2.03774 22.6037834613583 30.524609853229343 21.896382660727003 21.27376448275862 21.3695 1.165 14.823277445377347 22.27119542019751 14.554622267071451 56.93773827586208 37.6534 3.73641 77.60474307908488 57.125377204414804 69.50822052009451 6.5 11.8305 13.5 24.8889 7.62189;105.46;42.4094;12.4414;74.2041;31.8029;33.3125;17.6275;42.3152;45.9204;18.1231;38.7293;12.4747;8.62809;10.6467;11.9473;17.8395;55.3937;7.4229;48.1296;2.03774;43.1079;23.1906;8.54905;30.3423;31.2018;11.7137;33.4878;26.5872 5.49916;63.7532;26.2988;8.48981;49.8682;25.5756;25.7336;11.195;31.4035;34.2198;14.869;29.2097;7.00435;7.31865;8.92359;7.15307;14.6501;38.7444;5.75707;37.5433;1.165;31.8774;16.2815;7.19676;24.0157;26.858;8.36151;26.6039;21.3695 13.3925;422.699;81.7305;79.2355;155.425;42.1484;46.9856;37.6534;64.5991;70.4292;23.0103;57.2113;23.684;10.3909;13.0581;19.001;22.6149;96.8569;10.316;69.1421;3.73641;66.3058;33.4539;10.4125;41.1025;37.2719;18.9642;45.3228;35.0407 27 2 27 65192;246074;24539;171155;113965;85255;81869;29328;295143;65030;25315;171142;291075;29740;65210;24894;83842;29184;25284;65183;50681;192272;170570;50559;24158;25287;170465 SLC27A2_9860;SCD1_9787;LPL_32544;HADHB_8777;HADH_8776;HACL1_8775;GSTM7_8761;GPX4_32827;ETFDH_8575;EPHX2_33282;EPHX1_8567;EHHADH_8534;ECI2_8521;ECI1_8520;CYP2J4_32580;CYP2A1_32717;CROT_8384;CD36_8243;AMACR_8038;ALDH3A2_8024;ACOX1_7973;ACOT2_7969;ACOT12_32718;ACOT1_7968;ACADM_7957;ACADL_32776;ACAA2_7955 29.548795185185185 26.5872 23.0789885524505 21.561131851851854 21.3695 15.142296066033564 55.193644814814824 37.2719 80.24862583739407 7.62189;105.46;74.2041;31.8029;33.3125;17.6275;42.3152;45.9204;18.1231;38.7293;12.4747;8.62809;10.6467;11.9473;17.8395;55.3937;7.4229;48.1296;2.03774;43.1079;23.1906;8.54905;30.3423;31.2018;11.7137;33.4878;26.5872 5.49916;63.7532;49.8682;25.5756;25.7336;11.195;31.4035;34.2198;14.869;29.2097;7.00435;7.31865;8.92359;7.15307;14.6501;38.7444;5.75707;37.5433;1.165;31.8774;16.2815;7.19676;24.0157;26.858;8.36151;26.6039;21.3695 13.3925;422.699;155.425;42.1484;46.9856;37.6534;64.5991;70.4292;23.0103;57.2113;23.684;10.3909;13.0581;19.001;22.6149;96.8569;10.316;69.1421;3.73641;66.3058;33.4539;10.4125;41.1025;37.2719;18.9642;45.3228;35.0407 2 83516;29441 PPARGC1A_33189;POR_9531 27.4254 27.4254 21.190576018598453 17.394305 17.394305 12.592857595083418 80.483 80.483 1.764231419060398 42.4094;12.4414 26.2988;8.48981 81.7305;79.2355 0 Exp 2,11(0.38);Exp 4,1(0.04);Hill,3(0.11);Linear,9(0.32);Poly 2,4(0.14);Power,1(0.04) 3.297276659240826 462.99937415122986 1.520427942276001 344.14306640625 63.41602594994172 2.18471097946167 21.17541639861298 37.62929187724909 15.878641987259863 26.668886978257383 28.69249381584284 85.18298273588131 UP 0.9310344827586207 0.06896551724137931 0.0 GO:0043154 9 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process 41 42 3 3 2 3 2 2 160 40 2345 0.49392 0.75869 1.0 4.76 29441;24360 por;fabp1 POR_9531;FABP1_33091 23.1446 23.1446 12.4414 15.136610600791709 22.518358733436585 15.11067914529675 17.481705 17.481705 8.48981 12.716459860434824 16.95559171485115 12.694674513528488 63.080600000000004 63.080600000000004 46.9257 22.846478678781093 64.02581872311134 22.807338975666596 12.4414;33.8478 8.48981;26.4736 79.2355;46.9257 1 1 1 24360 FABP1_33091 33.8478 33.8478 26.4736 26.4736 46.9257 46.9257 33.8478 26.4736 46.9257 1 29441 POR_9531 12.4414 12.4414 8.48981 8.48981 79.2355 79.2355 12.4414 8.48981 79.2355 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.927898854620528 3.85727059841156 1.8753424882888794 1.9819281101226807 0.07536741597566582 1.92863529920578 2.1663280000000036 44.12287199999999 -0.14240919999999946 35.1058192 31.416995999999997 94.74420400000001 CONFLICT 0.5 0.5 0.0 GO:0051977 7 lysophospholipid transport 1 1 1 1 1 1 1 1 161 0 2385 1.0 0.063604 0.063604 100.0 24360 fabp1 FABP1_33091 33.8478 33.8478 33.8478 33.8478 26.4736 26.4736 26.4736 26.4736 46.9257 46.9257 46.9257 46.9257 0.0 33.8478 0.0 33.8478 33.8478 26.4736 46.9257 1 0 1 24360 FABP1_33091 33.8478 33.8478 26.4736 26.4736 46.9257 46.9257 33.8478 26.4736 46.9257 0 0 Exp 2,1(1) 1.8753424882888794 1.8753424882888794 1.8753424882888794 1.8753424882888794 0.0 1.8753424882888794 33.8478 33.8478 26.4736 26.4736 46.9257 46.9257 UP 1.0 0.0 0.0 GO:0016579 8 protein deubiquitination 9 9 1 1 1 1 1 1 161 8 2377 0.89218 0.44701 0.44701 11.11 312688 usp18 USP18_10138 108.883 108.883 108.883 108.883 73.1414 73.1414 73.1414 73.1414 138.144 138.144 138.144 138.144 0.0 108.883 0.0 108.883 108.883 73.1414 138.144 1 0 1 312688 USP18_10138 108.883 108.883 73.1414 73.1414 138.144 138.144 108.883 73.1414 138.144 0 0 Power,1(1) 1.705338716506958 1.705338716506958 1.705338716506958 1.705338716506958 0.0 1.705338716506958 108.883 108.883 73.1414 73.1414 138.144 138.144 UP 1.0 0.0 0.0 GO:0080135 5 regulation of cellular response to stress 165 174 16 16 13 13 12 12 150 162 2223 0.6889 0.42894 0.74706 6.9 24825;293615;25106;25513;25591;192235;24471;25675;299626;25112;294515;29184 tf;sirt3;rgn;pik3r1;parp1;hyou1;hspb1;hmgcr;gadd45b;gadd45a;foxo3;cd36 TF_10003;SIRT3_9828;RGN_9699;PIK3R1_32562;PARP1_9425;HYOU1_8857;HSPB1_8847;HMGCR_8810;GADD45B_8679;GADD45A_8678;FOXO3_8662;CD36_8243 47.6855225 42.676050000000004 1.63089 37.88462844835431 54.453425606998074 35.09709783504437 33.06237725 28.758200000000002 0.56209 27.755481785148902 40.43180654629006 28.411590891043765 61.6616975 61.9456 7.6286 37.7135636525578 68.92955912474767 35.64943645161254 7.5 62.78515 45.1539;2.38018;77.4407;18.7324;26.9741;40.1982;89.1011;1.63089;106.367;102.919;13.1992;48.1296 28.132;0.56209;58.7732;11.6701;21.799;29.3844;60.3265;0.663137;52.7132;89.5012;5.6804;37.5433 61.5341;8.82917;89.8047;41.5978;35.2797;62.3571;106.138;7.6286;109.434;115.437;32.7581;69.1421 6 6 6 24825;293615;25106;25591;299626;29184 TF_10003;SIRT3_9828;RGN_9699;PARP1_9425;GADD45B_8679;CD36_8243 51.074246666666674 46.64175 36.73725378712277 33.253798333333336 32.837650000000004 21.328389606222427 62.337295000000005 65.3381 36.37235582358324 45.1539;2.38018;77.4407;26.9741;106.367;48.1296 28.132;0.56209;58.7732;21.799;52.7132;37.5433 61.5341;8.82917;89.8047;35.2797;109.434;69.1421 6 25513;192235;24471;25675;25112;294515 PIK3R1_32562;HYOU1_8857;HSPB1_8847;HMGCR_8810;GADD45A_8678;FOXO3_8662 44.29679833333333 29.4653 42.194230180293815 32.870956166666666 20.52725 35.21106002390511 60.9861 51.977450000000005 42.48581691002305 18.7324;40.1982;89.1011;1.63089;102.919;13.1992 11.6701;29.3844;60.3265;0.663137;89.5012;5.6804 41.5978;62.3571;106.138;7.6286;115.437;32.7581 0 Exp 2,3(0.25);Exp 4,2(0.17);Hill,1(0.09);Poly 2,5(0.42);Power,1(0.09) 1.7845961732008093 21.654088377952576 1.5209722518920898 2.6703107357025146 0.30535908217057806 1.7086020708084106 26.250276075849815 69.1207689241502 17.3582350674594 48.766519432540605 40.32324009563375 83.00015490436625 CONFLICT 0.5 0.5 0.0 GO:0045669 7 positive regulation of osteoblast differentiation 22 22 1 1 1 1 1 1 161 21 2364 0.58705 0.76589 1.0 4.55 25695 cebpd CEBPD_8283 0.306936 0.306936 0.306936 0.306936 0.0732342 0.0732342 0.0732342 0.0732342 1.73689 1.73689 1.73689 1.73689 0.306936 0.0732342 1.73689 0 1 0 1 25695 CEBPD_8283 0.306936 0.306936 0.0732342 0.0732342 1.73689 1.73689 0.306936 0.0732342 1.73689 0 Hill,1(1) 1.627708911895752 1.627708911895752 1.627708911895752 1.627708911895752 0.0 1.627708911895752 0.306936 0.306936 0.0732342 0.0732342 1.73689 1.73689 DOWN 0.0 1.0 0.0 GO:0032496 5 response to lipopolysaccharide 176 189 23 23 20 22 19 19 143 170 2215 0.98563 0.027727 0.042157 10.05 79426;286954;24648;83516;81525;25493;24516;63868;24464;314322;25661;25256;25146;497840;29184;25698;312382;140668;25303 zfp36;ugt2b1;serpina1;ppargc1a;nfkbib;nfkbia;jun;hspd1;hp;fos;fn1;fmo1;cyp17a1;cps1;cd36;ass1;abcg2;abcc3;abcc2 ZFP36_10204;UGT2B10_33303,UGT2B1_33224;SERPINA1_9807;PPARGC1A_33189;NFKBIB_9308;NFKBIA_9307;JUN_8938;HSPD1_8849;HP_8823;FOS_8657;FN1_8655;FMO1_32787;CYP17A1_32365;CPS1_32421;CD36_8243;ASS1_33159;ABCG2_32656;ABCC3_7941;ABCC2_32541 33.2291986842106 37.7175 1.28141E-12 21.670734530863314 38.91042205333749 19.72817331339555 22.58257021052638 24.4836 1.28141E-12 14.124110692603294 26.140865759023818 12.510114547047008 56.08209263157901 48.9329 1.28142E-12 39.16817247953853 65.78288635082393 37.42175824596221 8.5 34.85005 17.5 65.10385 0.348134;47.47345;15.797;42.4094;30.5572;0.520151;16.4324;42.2579;64.9285;1.28141E-12;59.5777;65.2792;49.6922;31.9826;48.1296;26.8037;5.21654;37.7175;46.2316 0.118102;34.82915;13.013;26.2988;24.2439;0.160202;10.5224;23.9469;41.6103;1.28141E-12;31.0499;39.7882;35.6654;24.4836;37.5433;20.9825;2.73368;30.9007;31.1788 1.15962;76.47475;19.9134;81.7305;41.2611;2.88499;39.929;102.383;136.455;1.28142E-12;105.243;82.9415;81.6409;45.5891;69.1421;36.7081;11.386;48.9329;81.7848 9 11 8 286954;81525;63868;25256;25146;29184;312382;140668 UGT2B10_33303,UGT2B1_33224;NFKBIB_9308;HSPD1_8849;FMO1_32787;CYP17A1_32365;CD36_8243;ABCG2_32656;ABCC3_7941 40.79044875 44.865674999999996 17.56329187661863 28.70640375 32.864925 12.00462247041761 64.27028125 72.808425 28.87663588444495 47.47345;30.5572;42.2579;65.2792;49.6922;48.1296;5.21654;37.7175 34.82915;24.2439;23.9469;39.7882;35.6654;37.5433;2.73368;30.9007 76.47475;41.2611;102.383;82.9415;81.6409;69.1421;11.386;48.9329 11 79426;24648;83516;25493;24516;24464;314322;25661;497840;25698;25303 ZFP36_10204;SERPINA1_9807;PPARGC1A_33189;NFKBIA_9307;JUN_8938;HP_8823;FOS_8657;FN1_8655;CPS1_32421;ASS1_33159;ABCC2_32541 27.73010772727284 26.8037 23.460325329771177 18.128873090909206 20.9825 14.366113011890159 50.12704636363648 39.929 45.66305151602412 0.348134;15.797;42.4094;0.520151;16.4324;64.9285;1.28141E-12;59.5777;31.9826;26.8037;46.2316 0.118102;13.013;26.2988;0.160202;10.5224;41.6103;1.28141E-12;31.0499;24.4836;20.9825;31.1788 1.15962;19.9134;81.7305;2.88499;39.929;136.455;1.28142E-12;105.243;45.5891;36.7081;81.7848 0 Exp 2,11(0.55);Exp 3,1(0.05);Exp 4,2(0.1);Hill,2(0.1);Linear,1(0.05);Poly 2,2(0.1);Power,1(0.05) 1.8928625603530995 38.41592717170715 1.5074360370635986 3.0381598472595215 0.36608759609782643 1.8567861318588257 23.484848051022805 42.973549317398366 16.231595499693633 28.933544921359143 38.46993436540536 73.69425089775268 CONFLICT 0.42105263157894735 0.5789473684210527 0.0 GO:1901655 6 cellular response to ketone 66 69 16 16 12 12 9 9 153 60 2325 0.9894 0.028497 0.038567 13.04 286954;58954;294515;25661;116636;140942;25698;312382;25303 ugt2b1;klf6;foxo3;fn1;eif4ebp1;ddit4;ass1;abcg2;abcc2 UGT2B10_33303,UGT2B1_33224;KLF6_8969;FOXO3_8662;FN1_8655;EIF4EBP1_8550;DDIT4_8450;ASS1_33159;ABCG2_32656;ABCC2_32541 43.21022111111111 46.2316 5.21654 29.829117185633578 43.5630139315217 27.948024564804616 25.979147777777776 31.0499 2.73368 17.05207766570674 25.938337784591376 15.223242790564221 82.52387222222222 76.47475 11.386 69.579340651056 74.21954596184838 52.12450419745957 2.5 22.87565 5.5 53.525575 47.47345;18.9476;13.1992;59.5777;83.9001;87.5421;26.8037;5.21654;46.2316 34.82915;11.6941;5.6804;31.0499;42.4185;53.2453;20.9825;2.73368;31.1788 76.47475;45.5481;32.7581;105.243;107.32;245.492;36.7081;11.386;81.7848 4 6 3 286954;116636;312382 UGT2B10_33303,UGT2B1_33224;EIF4EBP1_8550;ABCG2_32656 45.530030000000004 47.47345 39.37776421460085 26.660443333333333 34.82915 21.065779384172647 65.06025 76.47475 48.9750058365234 47.47345;83.9001;5.21654 34.82915;42.4185;2.73368 76.47475;107.32;11.386 6 58954;294515;25661;140942;25698;25303 KLF6_8969;FOXO3_8662;FN1_8655;DDIT4_8450;ASS1_33159;ABCC2_32541 42.05031666666667 36.51765 28.258720486774827 25.638500000000004 26.0162 16.950303615333844 91.25568333333332 63.66645 80.69792229675846 18.9476;13.1992;59.5777;87.5421;26.8037;46.2316 11.6941;5.6804;31.0499;53.2453;20.9825;31.1788 45.5481;32.7581;105.243;245.492;36.7081;81.7848 0 Exp 2,4(0.4);Exp 3,1(0.1);Exp 4,2(0.2);Linear,1(0.1);Poly 2,1(0.1);Power,1(0.1) 1.7287300552652842 17.3445246219635 1.5074360370635986 1.9883413314819336 0.14876815975746702 1.7229295372962952 23.7218645498305 62.69857767239172 14.838457036182714 37.11983851937285 37.0653696635323 127.98237478091215 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0006663 6 platelet activating factor biosynthetic process 1 2 1 1 1 1 1 1 161 1 2384 0.99598 0.12319 0.12319 50.0 362866 chpt1 CHPT1_33298 16.0559 16.0559 16.0559 16.0559 10.6021 10.6021 10.6021 10.6021 29.905 29.905 29.905 29.905 0.0 16.0559 0.0 16.0559 16.0559 10.6021 29.905 1 0 1 362866 CHPT1_33298 16.0559 16.0559 10.6021 10.6021 29.905 29.905 16.0559 10.6021 29.905 0 0 Poly 2,1(1) 1.5922520160675049 1.5922520160675049 1.5922520160675049 1.5922520160675049 0.0 1.5922520160675049 16.0559 16.0559 10.6021 10.6021 29.905 29.905 UP 1.0 0.0 0.0 GO:0046469 6 platelet activating factor metabolic process 1 2 1 1 1 1 1 1 161 1 2384 0.99598 0.12319 0.12319 50.0 362866 chpt1 CHPT1_33298 16.0559 16.0559 16.0559 16.0559 10.6021 10.6021 10.6021 10.6021 29.905 29.905 29.905 29.905 0.0 16.0559 0.0 16.0559 16.0559 10.6021 29.905 1 0 1 362866 CHPT1_33298 16.0559 16.0559 10.6021 10.6021 29.905 29.905 16.0559 10.6021 29.905 0 0 Poly 2,1(1) 1.5922520160675049 1.5922520160675049 1.5922520160675049 1.5922520160675049 0.0 1.5922520160675049 16.0559 16.0559 10.6021 10.6021 29.905 29.905 UP 1.0 0.0 0.0 GO:0031099 4 regeneration 111 120 17 17 12 15 10 10 152 110 2275 0.86294 0.22937 0.33825 8.33 25106;85253;25493;24516;25685;24464;361969;113936;114851;25373 rgn;plg;nfkbia;jun;igfbp1;hp;fga;cpb2;cdkn1a;ahsg RGN_9699;PLG_9501;NFKBIA_9307;JUN_8938;IGFBP1_32306;HP_8823;FGA_8632;CPB2_8369;CDKN1A_8271;AHSG_8003 35.2196921 27.20595 0.520151 28.225139740690736 39.6425086084353 29.08167891932583 24.5697952 21.4832 0.160202 19.729489306996136 27.27738859633925 20.219684373470457 61.69543900000001 39.39005 2.88499 51.82246355170793 72.00639421465499 56.00000345116375 5.0 28.5803 77.4407;70.7857;0.520151;16.4324;49.0259;64.9285;28.5803;25.8316;6.24967;12.402 58.7732;46.2356;0.160202;10.5224;32.6883;41.6103;22.529;20.4374;2.44025;10.3013 89.8047;150.579;2.88499;39.929;89.1623;136.455;38.8511;34.8042;19.0606;15.4235 1 9 1 25106 RGN_9699 77.4407 77.4407 58.7732 58.7732 89.8047 89.8047 77.4407 58.7732 89.8047 9 85253;25493;24516;25685;24464;361969;113936;114851;25373 PLG_9501;NFKBIA_9307;JUN_8938;IGFBP1_32306;HP_8823;FGA_8632;CPB2_8369;CDKN1A_8271;AHSG_8003 30.528469000000005 25.8316 25.46871842274374 20.76941688888889 20.4374 16.595993331046568 58.57218777777777 38.8511 53.95853352271163 70.7857;0.520151;16.4324;49.0259;64.9285;28.5803;25.8316;6.24967;12.402 46.2356;0.160202;10.5224;32.6883;41.6103;22.529;20.4374;2.44025;10.3013 150.579;2.88499;39.929;89.1623;136.455;38.8511;34.8042;19.0606;15.4235 0 Exp 2,4(0.4);Exp 4,2(0.2);Linear,2(0.2);Poly 2,2(0.2) 1.9470984201584625 20.726802229881287 1.522104263305664 3.9562058448791504 0.8763240916247702 1.6767547726631165 17.72556924400506 52.713814955994934 12.341331036719225 36.798259363280785 29.575543318246595 93.8153346817534 DOWN 0.1 0.9 0.0 GO:0032355 5 response to estradiol 114 121 19 19 17 16 14 14 148 107 2278 0.99157 0.019211 0.032625 11.57 24648;83516;25513;24314;29540;29328;24384;361969;24890;29184;25698;312382;140668;25303 serpina1;ppargc1a;pik3r1;nqo1;hsd17b7;gpx4;gc;fga;esr1;cd36;ass1;abcg2;abcc3;abcc2 SERPINA1_9807;PPARGC1A_33189;PIK3R1_32562;NQO1_33055;HSD17B7_8834;GPX4_32827;GC_32893;FGA_8632;ESR1_33192;CD36_8243;ASS1_33159;ABCG2_32656;ABCC3_7941;ABCC2_32541 33.53897385714286 33.1489 0.977494 21.764695270358004 32.415130834209954 17.156374333971698 24.055183 24.413899999999998 0.322682 15.377285549213562 23.337911119079187 12.59873968872688 58.12582285714286 45.26535 5.49472 47.574746133458305 52.933114981860584 32.07713392536474 5.5 27.692 11.5 47.1806 15.797;42.4094;18.7324;87.2765;0.977494;45.9204;42.356;28.5803;23.3972;48.1296;26.8037;5.21654;37.7175;46.2316 13.013;26.2988;11.6701;60.6992;0.322682;34.2198;26.3722;22.529;18.3088;37.5433;20.9825;2.73368;30.9007;31.1788 19.9134;81.7305;41.5978;197.117;5.49472;70.4292;78.7583;38.8511;31.9156;69.1421;36.7081;11.386;48.9329;81.7848 5 9 5 24314;29328;29184;312382;140668 NQO1_33055;GPX4_32827;CD36_8243;ABCG2_32656;ABCC3_7941 44.852108 45.9204 29.298434771218062 33.219336 34.2198 20.673605231054403 79.40144000000001 69.1421 69.99489306744456 87.2765;45.9204;48.1296;5.21654;37.7175 60.6992;34.2198;37.5433;2.73368;30.9007 197.117;70.4292;69.1421;11.386;48.9329 9 24648;83516;25513;29540;24384;361969;24890;25698;25303 SERPINA1_9807;PPARGC1A_33189;PIK3R1_32562;HSD17B7_8834;GC_32893;FGA_8632;ESR1_33192;ASS1_33159;ABCC2_32541 27.253899333333337 26.8037 14.701521545306253 18.96398688888889 20.9825 9.42873948756922 46.30603555555556 38.8511 28.075496684802875 15.797;42.4094;18.7324;0.977494;42.356;28.5803;23.3972;26.8037;46.2316 13.013;26.2988;11.6701;0.322682;26.3722;22.529;18.3088;20.9825;31.1788 19.9134;81.7305;41.5978;5.49472;78.7583;38.8511;31.9156;36.7081;81.7848 0 Exp 2,9(0.65);Exp 3,1(0.08);Exp 4,2(0.15);Linear,1(0.08);Poly 2,1(0.08) 1.8421986189757122 26.448557496070862 1.5074360370635986 3.0381598472595215 0.4777054630835189 1.7141099572181702 22.137929261052218 44.94001845323349 16.000068231075407 32.110297768924596 33.204646815961965 83.04699889832376 DOWN 0.35714285714285715 0.6428571428571429 0.0 GO:0043255 6 regulation of carbohydrate biosynthetic process 35 36 3 3 3 2 2 2 160 34 2351 0.59583 0.67866 1.0 5.56 192280;24158 ppp1r3b;acadm PPP1R3B_9545;ACADM_7957 23.9274 23.9274 11.7137 17.27278018675628 28.91062069047809 15.769716499670563 17.710155 17.710155 8.36151 13.220980548811424 21.524425957362187 12.070501265469323 36.2943 36.2943 18.9642 24.508462457281976 43.36502491448572 22.375755414898105 0.5 23.9274 36.1411;11.7137 27.0588;8.36151 53.6244;18.9642 1 1 1 24158 ACADM_7957 11.7137 11.7137 8.36151 8.36151 18.9642 18.9642 11.7137 8.36151 18.9642 1 192280 PPP1R3B_9545 36.1411 36.1411 27.0588 27.0588 53.6244 53.6244 36.1411 27.0588 53.6244 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.784035743068797 3.5729598999023438 1.693061113357544 1.8798987865447998 0.1321141856918246 1.7864799499511719 -0.011452000000002016 47.866252 -0.6131892000000008 36.0334992 2.327304000000005 70.26129599999999 CONFLICT 0.5 0.5 0.0 GO:0050680 7 negative regulation of epithelial cell proliferation 40 44 4 4 3 3 3 3 159 41 2344 0.69437 0.53806 0.75678 6.82 24794;25106;113936 serpina3c;rgn;cpb2 SERPINA3C_32925;RGN_9699;CPB2_8369 44.3461 29.766 25.8316 28.72819673613367 55.83149461777636 29.75030506272049 34.18586666666667 23.347 20.4374 21.342894915482603 42.717638854937285 22.10411857459121 55.14483333333334 40.8256 34.8042 30.166936909526164 67.3430177870698 30.96778365323386 1.5 53.603350000000006 29.766;77.4407;25.8316 23.347;58.7732;20.4374 40.8256;89.8047;34.8042 1 2 1 25106 RGN_9699 77.4407 77.4407 58.7732 58.7732 89.8047 89.8047 77.4407 58.7732 89.8047 2 24794;113936 SERPINA3C_32925;CPB2_8369 27.7988 27.7988 2.7820409199003393 21.892200000000003 21.892200000000003 2.0573978905403405 37.8149 37.8149 4.257772772236681 29.766;25.8316 23.347;20.4374 40.8256;34.8042 0 Exp 2,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 1.6331185495803815 4.903179407119751 1.5630855560302734 1.7198865413665771 0.07935720190844962 1.6202073097229004 11.83708504687899 76.85511495312102 10.0341074621767 58.33762587115664 21.007730608464193 89.28193605820249 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0150078 8 positive regulation of neuroinflammatory response 1 1 1 1 1 1 1 1 161 0 2385 1.0 0.063604 0.063604 100.0 25423 ctsc CTSC_32456 56.2386 56.2386 56.2386 56.2386 38.2681 38.2681 38.2681 38.2681 102.888 102.888 102.888 102.88799999999999 0.0 56.2386 0.0 56.2386 56.2386 38.2681 102.888 0 1 0 1 25423 CTSC_32456 56.2386 56.2386 38.2681 38.2681 102.888 102.888 56.2386 38.2681 102.888 0 Exp 2,1(1) 1.5736411809921265 1.5736411809921265 1.5736411809921265 1.5736411809921265 0.0 1.5736411809921265 56.2386 56.2386 38.2681 38.2681 102.888 102.888 DOWN 0.0 1.0 0.0 GO:1903980 8 positive regulation of microglial cell activation 1 1 1 1 1 1 1 1 161 0 2385 1.0 0.063604 0.063604 100.0 25423 ctsc CTSC_32456 56.2386 56.2386 56.2386 56.2386 38.2681 38.2681 38.2681 38.2681 102.888 102.888 102.888 102.88799999999999 0.0 56.2386 0.0 56.2386 56.2386 38.2681 102.888 0 1 0 1 25423 CTSC_32456 56.2386 56.2386 38.2681 38.2681 102.888 102.888 56.2386 38.2681 102.888 0 Exp 2,1(1) 1.5736411809921265 1.5736411809921265 1.5736411809921265 1.5736411809921265 0.0 1.5736411809921265 56.2386 56.2386 38.2681 38.2681 102.888 102.888 DOWN 0.0 1.0 0.0 GO:0006707 6 cholesterol catabolic process 4 4 2 2 2 1 1 1 161 3 2382 0.97784 0.23128 0.23128 25.0 25428 cyp7a1 CYP7A1_8430 5.72128 5.72128 5.72128 5.72128 0.985273 0.985273 0.985273 0.985273 22.3625 22.3625 22.3625 22.3625 0.0 5.72128 0.0 5.72128 5.72128 0.985273 22.3625 0 1 0 1 25428 CYP7A1_8430 5.72128 5.72128 0.985273 0.985273 22.3625 22.3625 5.72128 0.985273 22.3625 0 Hill,1(1) 4.560328960418701 4.560328960418701 4.560328960418701 4.560328960418701 0.0 4.560328960418701 5.72128 5.72128 0.985273 0.985273 22.3625 22.3625 DOWN 0.0 1.0 0.0 GO:0016127 6 sterol catabolic process 4 4 2 2 2 1 1 1 161 3 2382 0.97784 0.23128 0.23128 25.0 25428 cyp7a1 CYP7A1_8430 5.72128 5.72128 5.72128 5.72128 0.985273 0.985273 0.985273 0.985273 22.3625 22.3625 22.3625 22.3625 0.0 5.72128 0.0 5.72128 5.72128 0.985273 22.3625 0 1 0 1 25428 CYP7A1_8430 5.72128 5.72128 0.985273 0.985273 22.3625 22.3625 5.72128 0.985273 22.3625 0 Hill,1(1) 4.560328960418701 4.560328960418701 4.560328960418701 4.560328960418701 0.0 4.560328960418701 5.72128 5.72128 0.985273 0.985273 22.3625 22.3625 DOWN 0.0 1.0 0.0 GO:0008203 6 cholesterol metabolic process 48 49 14 14 9 9 5 5 157 44 2341 0.91266 0.19785 0.23655 10.2 293688;29540;25675;246186;25428 tm7sf2;hsd17b7;hmgcr;fgl1;cyp7a1 TM7SF2_10031;HSD17B7_8834;HMGCR_8810;FGL1_8640;CYP7A1_8430 21.2230128 5.72128 0.977494 34.636147969230485 25.99912214869384 33.20542211235907 12.670898400000002 0.985273 0.322682 21.916922574364822 16.263615376123305 20.707062374907277 55.147684000000005 22.3625 5.49472 87.09277122073496 62.6826392048067 85.81289720229971 1.5 3.676085 3.5 48.892700000000005 82.3097;0.977494;1.63089;15.4757;5.72128 51.1696;0.322682;0.663137;10.2138;0.985273 209.842;5.49472;7.6286;30.4106;22.3625 0 5 0 5 293688;29540;25675;246186;25428 TM7SF2_10031;HSD17B7_8834;HMGCR_8810;FGL1_8640;CYP7A1_8430 21.2230128 5.72128 34.636147969230485 12.670898400000002 0.985273 21.916922574364822 55.147684000000005 22.3625 87.09277122073496 82.3097;0.977494;1.63089;15.4757;5.72128 51.1696;0.322682;0.663137;10.2138;0.985273 209.842;5.49472;7.6286;30.4106;22.3625 0 Exp 4,2(0.4);Hill,1(0.2);Linear,1(0.2);Poly 2,1(0.2) 2.075406309624322 11.401422262191772 1.511321783065796 4.560328960418701 1.2820657574116672 1.7248681783676147 -9.136909484472742 51.58293508447274 -6.5401312636807365 31.88192806368074 -21.192495864973083 131.48786386497306 DOWN 0.0 1.0 0.0 GO:0002697 5 regulation of immune effector process 103 117 7 6 4 5 3 3 159 114 2271 0.051855 0.9834 0.11649 2.56 65164;63868;29184 htra1;hspd1;cd36 HTRA1_8856;HSPD1_8849;CD36_8243 41.17326666666667 42.2579 33.1323 7.557253067307814 41.5348104335863 7.828528325485799 29.034900000000004 25.6145 23.9469 7.4155158525890705 29.873095854968273 7.631195211387569 72.72933333333333 69.1421 46.6629 28.03272316852814 70.67779424843562 26.445968874867834 33.1323;42.2579;48.1296 25.6145;23.9469;37.5433 46.6629;102.383;69.1421 2 1 2 63868;29184 HSPD1_8849;CD36_8243 45.19375 45.19375 4.151918887092963 30.7451 30.7451 9.61410663972478 85.76255 85.76255 23.504865802743858 42.2579;48.1296 23.9469;37.5433 102.383;69.1421 1 65164 HTRA1_8856 33.1323 33.1323 25.6145 25.6145 46.6629 46.6629 33.1323 25.6145 46.6629 0 Exp 2,1(0.34);Exp 3,1(0.34);Linear,1(0.34) 2.109133652015309 6.482471466064453 1.5603101253509521 2.6703107357025146 0.5605709100205555 2.2518506050109863 32.62142976488785 49.725103568445476 20.6434538556024 37.4263461443976 41.007320809096115 104.45134585757054 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0042304 7 regulation of fatty acid biosynthetic process 23 24 6 6 4 6 4 4 158 20 2365 0.98452 0.061808 0.061808 16.67 246273;25106;25428;25287 trib3;rgn;cyp7a1;acadl TRIB3_10079;RGN_9699;CYP7A1_8430;ACADL_32776 56.178444999999996 55.46425000000001 5.72128 45.47887852507763 72.07808251316197 37.95756952810165 42.56149325 42.68855 0.985273 36.30226262285106 55.25058973358625 29.88309478418359 75.2295 67.56375 22.3625 53.39413903909929 91.83393624961289 47.15894292113515 0.5 19.60454 1.5 55.46425000000001 108.064;77.4407;5.72128;33.4878 83.8836;58.7732;0.985273;26.6039 143.428;89.8047;22.3625;45.3228 2 2 2 25106;25287 RGN_9699;ACADL_32776 55.46425000000001 55.46425000000001 31.07939364281419 42.68855 42.68855 22.747130176024417 67.56375 67.56375 31.453453130061888 77.4407;33.4878 58.7732;26.6039 89.8047;45.3228 2 246273;25428 TRIB3_10079;CYP7A1_8430 56.89264 56.89264 72.36723131707609 42.434436500000004 42.434436500000004 58.61796917071986 82.89525 82.89525 85.60623601773996 108.064;5.72128 83.8836;0.985273 143.428;22.3625 0 Exp 2,1(0.25);Hill,1(0.25);Poly 2,2(0.5) 2.295905091275931 10.044577956199646 1.7198865413665771 4.560328960418701 1.3682697846734388 1.8821812272071838 11.609144045423932 100.74774595457608 6.9852758796059575 78.13771062039405 22.9032437416827 127.5557562583173 CONFLICT 0.5 0.5 0.0 GO:0090066 4 regulation of anatomical structure size 103 112 9 9 6 8 5 5 157 107 2278 0.27076 0.85269 0.55107 4.46 288001;25675;361969;497840;155423 kng1;hmgcr;fga;cps1;anxa7 KNG1L1_34113;HMGCR_8810;FGA_8632;CPS1_32421;ANXA7_8051 38.239858000000005 28.5803 1.63089 38.96842806680582 45.29258924664323 36.85007967826948 22.227827400000002 22.529 0.663137 15.396711622776914 26.67037330188339 11.905149418012643 46.5809 38.8511 7.6286 37.5625390709281 54.65146248986211 34.10919795445593 24.3655;1.63089;28.5803;31.9826;104.64 19.538;0.663137;22.529;24.4836;43.9254 32.1467;7.6286;38.8511;45.5891;108.689 1 4 1 155423 ANXA7_8051 104.64 104.64 43.9254 43.9254 108.689 108.689 104.64 43.9254 108.689 4 288001;25675;361969;497840 KNG1L1_34113;HMGCR_8810;FGA_8632;CPS1_32421 21.6398225 26.472900000000003 13.69829639001477 16.80343425 21.0335 10.950709174363654 31.053875 35.498900000000006 16.55301844385187 24.3655;1.63089;28.5803;31.9826 19.538;0.663137;22.529;24.4836 32.1467;7.6286;38.8511;45.5891 0 Exp 2,1(0.2);Exp 3,1(0.2);Exp 4,1(0.2);Linear,2(0.4) 1.8152968221608252 9.196730375289917 1.541895866394043 2.3804118633270264 0.34323436435748605 1.8264755010604858 4.082524779594095 72.3971912204059 8.73201462315181 35.72364017684819 13.655882818125889 79.50591718187411 DOWN 0.2 0.8 0.0 GO:1904237 8 positive regulation of substrate-dependent cell migration, cell attachment to substrate 1 1 1 1 1 1 1 1 161 0 2385 1.0 0.063604 0.063604 100.0 25661 fn1 FN1_8655 59.5777 59.5777 59.5777 59.5777 31.0499 31.0499 31.0499 31.0499 105.243 105.243 105.243 105.243 0.0 59.5777 0.0 59.5777 59.5777 31.0499 105.243 0 1 0 1 25661 FN1_8655 59.5777 59.5777 31.0499 31.0499 105.243 105.243 59.5777 31.0499 105.243 0 Power,1(1) 1.7792335748672485 1.7792335748672485 1.7792335748672485 1.7792335748672485 0.0 1.7792335748672485 59.5777 59.5777 31.0499 31.0499 105.243 105.243 DOWN 0.0 1.0 0.0 GO:0072301 8 regulation of metanephric glomerular mesangial cell proliferation 1 1 1 1 1 1 1 1 161 0 2385 1.0 0.063604 0.063604 100.0 24330 egr1 EGR1_8533 0.750017 0.750017 0.750017 0.750017 0.186019 0.186019 0.186019 0.186019 4.70178 4.70178 4.70178 4.70178 0.0 0.750017 0.0 0.750017 0.750017 0.186019 4.70178 0 1 0 1 24330 EGR1_8533 0.750017 0.750017 0.186019 0.186019 4.70178 4.70178 0.750017 0.186019 4.70178 0 Hill,1(1) 4.21828556060791 4.21828556060791 4.21828556060791 4.21828556060791 0.0 4.21828556060791 0.750017 0.750017 0.186019 0.186019 4.70178 4.70178 DOWN 0.0 1.0 0.0 GO:0072303 8 positive regulation of glomerular metanephric mesangial cell proliferation 1 1 1 1 1 1 1 1 161 0 2385 1.0 0.063604 0.063604 100.0 24330 egr1 EGR1_8533 0.750017 0.750017 0.750017 0.750017 0.186019 0.186019 0.186019 0.186019 4.70178 4.70178 4.70178 4.70178 0.0 0.750017 0.0 0.750017 0.750017 0.186019 4.70178 0 1 0 1 24330 EGR1_8533 0.750017 0.750017 0.186019 0.186019 4.70178 4.70178 0.750017 0.186019 4.70178 0 Hill,1(1) 4.21828556060791 4.21828556060791 4.21828556060791 4.21828556060791 0.0 4.21828556060791 0.750017 0.750017 0.186019 0.186019 4.70178 4.70178 DOWN 0.0 1.0 0.0 GO:0019932 6 second-messenger-mediated signaling 68 74 5 5 4 4 3 3 159 71 2314 0.29593 0.86102 0.62592 4.05 24567;81678;29184 mt1;itpr2;cd36 MT1A_9255;ITPR2_8931;CD36_8243 30.957399999999996 31.8111 12.9315 17.61457248047764 37.445605925570995 14.179311807760742 23.729276666666667 24.7342 8.91033 14.342912742348867 29.045362929776932 11.422261279948057 45.64509999999999 44.3296 23.4636 22.86764626606773 53.76812994729276 19.404023086984385 12.9315;31.8111;48.1296 8.91033;24.7342;37.5433 23.4636;44.3296;69.1421 1 2 1 29184 CD36_8243 48.1296 48.1296 37.5433 37.5433 69.1421 69.1421 48.1296 37.5433 69.1421 2 24567;81678 MT1A_9255;ITPR2_8931 22.371299999999998 22.371299999999998 13.349893186089549 16.822265 16.822265 11.189165781614372 33.8966 33.8966 14.7544900962385 12.9315;31.8111 8.91033;24.7342 23.4636;44.3296 0 Exp 2,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 2.1632170580879135 6.611194133758545 1.6674995422363281 2.6703107357025146 0.5050209631228157 2.273383855819702 11.02463480000268 50.89016519999732 7.498742982460147 39.959810350873184 19.767922214203235 71.52227778579676 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:1904814 7 regulation of protein localization to chromosome, telomeric region 3 3 1 1 1 1 1 1 161 2 2383 0.98844 0.179 0.179 33.33 290556 gnl3 GNL3_8735 87.6357 87.6357 87.6357 87.6357 54.41 54.41 54.41 54.41 238.963 238.963 238.963 238.963 0.0 87.6357 0.0 87.6357 87.6357 54.41 238.963 1 0 1 290556 GNL3_8735 87.6357 87.6357 54.41 54.41 238.963 238.963 87.6357 54.41 238.963 0 0 Exp 2,1(1) 1.582527995109558 1.582527995109558 1.582527995109558 1.582527995109558 0.0 1.582527995109558 87.6357 87.6357 54.41 54.41 238.963 238.963 UP 1.0 0.0 0.0 GO:1904816 7 positive regulation of protein localization to chromosome, telomeric region 3 3 1 1 1 1 1 1 161 2 2383 0.98844 0.179 0.179 33.33 290556 gnl3 GNL3_8735 87.6357 87.6357 87.6357 87.6357 54.41 54.41 54.41 54.41 238.963 238.963 238.963 238.963 0.0 87.6357 0.0 87.6357 87.6357 54.41 238.963 1 0 1 290556 GNL3_8735 87.6357 87.6357 54.41 54.41 238.963 238.963 87.6357 54.41 238.963 0 0 Exp 2,1(1) 1.582527995109558 1.582527995109558 1.582527995109558 1.582527995109558 0.0 1.582527995109558 87.6357 87.6357 54.41 54.41 238.963 238.963 UP 1.0 0.0 0.0 GO:0071356 7 cellular response to tumor necrosis factor 67 70 7 7 5 7 5 5 157 65 2320 0.71574 0.4627 0.8015 7.14 79426;83516;25493;25698;25303 zfp36;ppargc1a;nfkbia;ass1;abcc2 ZFP36_10204;PPARGC1A_33189;NFKBIA_9307;ASS1_33159;ABCC2_32541 23.262597 26.8037 0.348134 22.073774252677726 30.28803477449657 18.456098237917505 15.747680800000001 20.9825 0.118102 14.697806953758139 20.596676223613883 11.927446256966755 40.853602 36.7081 1.15962 39.93963147949816 52.52566754197485 35.43562596638043 2.5 34.60655 0.348134;42.4094;0.520151;26.8037;46.2316 0.118102;26.2988;0.160202;20.9825;31.1788 1.15962;81.7305;2.88499;36.7081;81.7848 0 5 0 5 79426;83516;25493;25698;25303 ZFP36_10204;PPARGC1A_33189;NFKBIA_9307;ASS1_33159;ABCC2_32541 23.262597 26.8037 22.073774252677726 15.747680800000001 20.9825 14.697806953758139 40.853602 36.7081 39.93963147949816 0.348134;42.4094;0.520151;26.8037;46.2316 0.118102;26.2988;0.160202;20.9825;31.1788 1.15962;81.7305;2.88499;36.7081;81.7848 0 Exp 2,3(0.6);Exp 4,1(0.2);Hill,1(0.2) 1.857231545111394 9.290801644325256 1.7576230764389038 1.9381765127182007 0.06531668652741891 1.8589661121368408 3.914080778402976 42.61111322159702 2.864484976241256 28.630876623758745 5.844971454096232 75.86223254590377 DOWN 0.0 1.0 0.0 GO:0050830 6 defense response to Gram-positive bacterium 27 33 2 2 2 2 2 2 160 31 2354 0.64906 0.63119 1.0 6.06 246074;29184 scd;cd36 SCD1_9787;CD36_8243 76.7948 76.7948 48.1296 40.53871460813724 65.42229127432518 37.21181899140244 50.648250000000004 50.648250000000004 37.5433 18.533198024221278 45.449048242310106 17.01223181039657 245.92055 245.92055 69.1421 250.0024815252941 175.7862245762712 229.48549750152412 0.5 76.7948 105.46;48.1296 63.7532;37.5433 422.699;69.1421 2 0 2 246074;29184 SCD1_9787;CD36_8243 76.7948 76.7948 40.53871460813724 50.648250000000004 50.648250000000004 18.533198024221278 245.92055 245.92055 250.0024815252941 105.46;48.1296 63.7532;37.5433 422.699;69.1421 0 0 Exp 2,2(1) 2.44397412146565 4.907132625579834 2.2368218898773193 2.6703107357025146 0.3065229024517254 2.453566312789917 20.611008000000005 132.978592 24.96254800000001 76.333952 -100.56521200000003 592.4063120000001 UP 1.0 0.0 0.0 GO:0002521 5 leukocyte differentiation 80 87 7 7 5 6 5 5 157 82 2303 0.51875 0.65955 1.0 5.75 24825;363465;25513;24516;24330 tf;pir;pik3r1;jun;egr1 TF_10003;PIR_9487;PIK3R1_32562;JUN_8938;EGR1_8533 26.219883399999997 18.7324 0.750017 20.77271831737671 29.669231276346014 22.401507448340706 17.8564438 11.6701 0.186019 15.389427846865924 20.565312093072507 16.68637555959224 44.154196 41.5978 4.70178 26.055234362198316 46.722817022972 28.65040453776453 3.5 47.5923 45.1539;50.0307;18.7324;16.4324;0.750017 28.132;38.7717;11.6701;10.5224;0.186019 61.5341;73.0083;41.5978;39.929;4.70178 2 3 2 24825;363465 TF_10003;PIR_9487 47.5923 47.5923 3.4484183504904795 33.45185 33.45185 7.523404019790535 67.27120000000001 67.27120000000001 8.113484628690525 45.1539;50.0307 28.132;38.7717 61.5341;73.0083 3 25513;24516;24330 PIK3R1_32562;JUN_8938;EGR1_8533 11.971605666666667 16.4324 9.785986876799717 7.459506333333333 10.5224 6.3251100633601895 28.742859999999997 39.929 20.83689921832901 18.7324;16.4324;0.750017 11.6701;10.5224;0.186019 41.5978;39.929;4.70178 0 Exp 2,1(0.2);Hill,1(0.2);Poly 2,3(0.6) 2.174382933926702 11.601764559745789 1.6735800504684448 4.21828556060791 1.0668525840912393 1.8969218730926514 8.011792987837126 44.427973812162875 4.367015534235197 31.345872065764805 21.315776120202987 66.99261587979703 DOWN 0.4 0.6 0.0 GO:0061179 7 negative regulation of insulin secretion involved in cellular response to glucose stimulus 2 2 1 1 1 1 1 1 161 1 2384 0.99598 0.12319 0.12319 50.0 25675 hmgcr HMGCR_8810 1.63089 1.63089 1.63089 1.63089 0.663137 0.663137 0.663137 0.6631370000000001 7.6286 7.6286 7.6286 7.6286 0.0 1.63089 0.0 1.63089 1.63089 0.663137 7.6286 0 1 0 1 25675 HMGCR_8810 1.63089 1.63089 0.663137 0.663137 7.6286 7.6286 1.63089 0.663137 7.6286 0 Exp 4,1(1) 1.9017701148986816 1.9017701148986816 1.9017701148986816 1.9017701148986816 0.0 1.9017701148986816 1.63089 1.63089 0.663137 0.663137 7.6286 7.6286 DOWN 0.0 1.0 0.0 GO:1990928 5 response to amino acid starvation 14 16 2 2 2 2 2 2 160 14 2371 0.92323 0.27077 0.27077 12.5 116636;114851 eif4ebp1;cdkn1a EIF4EBP1_8550;CDKN1A_8271 45.074884999999995 45.074884999999995 6.24967 54.90714561505132 38.73499831080644 54.17016072644442 22.429375 22.429375 2.44025 28.268891674971094 19.165290370561987 27.88945570632355 63.19029999999999 63.19029999999999 19.0606 62.40882024345598 55.98422792472353 61.5711449842525 0.0 6.24967 0.5 45.074884999999995 83.9001;6.24967 42.4185;2.44025 107.32;19.0606 1 1 1 116636 EIF4EBP1_8550 83.9001 83.9001 42.4185 42.4185 107.32 107.32 83.9001 42.4185 107.32 1 114851 CDKN1A_8271 6.24967 6.24967 2.44025 2.44025 19.0606 19.0606 6.24967 2.44025 19.0606 0 Exp 3,1(0.5);Exp 4,1(0.5) 1.5956993736595368 3.194957137107849 1.522104263305664 1.672852873802185 0.10659536473653955 1.5974785685539246 -31.022536399999993 121.17230639999998 -16.74931 61.60806 -23.303911999999997 149.68451199999998 CONFLICT 0.5 0.5 0.0 GO:0015936 7 coenzyme A metabolic process 6 6 4 4 3 4 3 3 159 3 2382 0.99979 0.0043808 0.0043808 50.0 298490;25675;83842 ppcs;hmgcr;crot PPCS_9540;HMGCR_8810;CROT_8384 9.796363333333334 7.4229 1.63089 9.575423463640307 13.700962135213397 9.247311998172545 7.7281689999999985 5.75707 0.663137 8.229567785673376 11.086643819967264 7.926512240116638 14.538566666666668 10.316 7.6286 9.73424385883841 18.377149351630365 9.925059448652949 0.0 1.63089 0.0 1.63089 20.3353;1.63089;7.4229 16.7643;0.663137;5.75707 25.6711;7.6286;10.316 2 1 2 298490;83842 PPCS_9540;CROT_8384 13.879100000000001 13.879100000000001 9.130445601393173 11.260684999999999 11.260684999999999 7.78328697508 17.99355 17.99355 10.857695335797558 20.3353;7.4229 16.7643;5.75707 25.6711;10.316 1 25675 HMGCR_8810 1.63089 1.63089 0.663137 0.663137 7.6286 7.6286 1.63089 0.663137 7.6286 0 Exp 2,1(0.34);Exp 4,1(0.34);Poly 2,1(0.34) 2.9961720798722213 10.236906290054321 1.9017701148986816 5.963563919067383 2.221909354075195 2.371572256088257 -1.0392483627679514 20.63197502943462 -1.5844636256906828 17.040801625690683 3.523232774641345 25.553900558691993 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0045017 5 glycerolipid biosynthetic process 25 29 6 6 3 6 3 3 159 26 2359 0.8916 0.27947 0.42657 10.34 25513;24539;362866 pik3r1;lpl;chpt1 PIK3R1_32562;LPL_32544;CHPT1_33298 36.3308 18.7324 16.0559 32.82652970891075 43.755372353903816 35.02696271403651 24.0468 11.6701 10.6021 22.36836336145316 29.179965565116404 23.790956589048967 75.6426 41.5978 29.905 69.34049253704505 90.71318590508369 74.5639168771792 0.5 17.39415 1.5 46.46825 18.7324;74.2041;16.0559 11.6701;49.8682;10.6021 41.5978;155.425;29.905 2 1 2 24539;362866 LPL_32544;CHPT1_33298 45.129999999999995 45.129999999999995 41.116986533791604 30.23515 30.23515 27.765325580749092 92.665 92.665 88.75604317453545 74.2041;16.0559 49.8682;10.6021 155.425;29.905 1 25513 PIK3R1_32562 18.7324 18.7324 11.6701 11.6701 41.5978 41.5978 18.7324 11.6701 41.5978 0 Exp 2,1(0.34);Poly 2,2(0.67) 1.6077006780465037 4.825231194496155 1.559399127960205 1.6735800504684448 0.05878044530474383 1.5922520160675049 -0.8159152974417054 73.4775152974417 -1.2653859918100352 49.35898599181004 -2.823553982728228 154.10875398272822 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0008643 6 carbohydrate transport 15 17 3 3 3 2 2 2 160 15 2370 0.91096 0.295 0.295 11.76 25351;65054 slc2a2;aqp9 SLC2A2_9863;AQP9_32709 28.74355 28.74355 27.7316 1.4311134144435667 29.02560369670238 1.3744006073023092 22.638550000000002 22.638550000000002 21.9372 0.9918586819703213 22.83403234614577 0.9525528592634062 39.13525 39.13525 37.4625 2.365625736459578 39.601483826927115 2.271879653999849 0.0 27.7316 0.5 28.74355 29.7555;27.7316 23.3399;21.9372 40.808;37.4625 0 2 0 2 25351;65054 SLC2A2_9863;AQP9_32709 28.74355 28.74355 1.4311134144435667 22.638550000000002 22.638550000000002 0.9918586819703213 39.13525 39.13525 2.365625736459578 29.7555;27.7316 23.3399;21.9372 40.808;37.4625 0 Linear,2(1) 1.7925277976947924 3.585388422012329 1.7682682275772095 1.8171201944351196 0.03454355703952875 1.7926942110061646 26.760127999999998 30.726972 21.263904000000004 24.013196 35.85666 42.41384 DOWN 0.0 1.0 0.0 GO:1902983 10 DNA strand elongation involved in mitotic DNA replication 1 1 1 1 1 1 1 1 161 0 2385 1.0 0.063604 0.063604 100.0 499914 gins1 GINS1_8707 58.9165 58.9165 58.9165 58.916500000000006 44.7208 44.7208 44.7208 44.72079999999999 91.837 91.837 91.837 91.837 0.0 58.9165 0.0 58.9165 58.9165 44.7208 91.837 1 0 1 499914 GINS1_8707 58.9165 58.9165 44.7208 44.7208 91.837 91.837 58.9165 44.7208 91.837 0 0 Exp 2,1(1) 1.5715726613998413 1.5715726613998413 1.5715726613998413 1.5715726613998413 0.0 1.5715726613998413 58.9165 58.9165 44.7208 44.7208 91.837 91.837 UP 1.0 0.0 0.0 GO:0071354 7 cellular response to interleukin-6 12 12 3 3 3 3 3 3 159 9 2376 0.99478 0.036309 0.036309 25.0 83516;361969;25303 ppargc1a;fga;abcc2 PPARGC1A_33189;FGA_8632;ABCC2_32541 39.073766666666664 42.4094 28.5803 9.286384399933763 36.31936620458115 9.558636627340563 26.668866666666663 26.2988 22.529 4.336758237823891 25.422612476309094 4.090943455118373 67.45546666666667 81.7305 38.8511 24.772123070567325 60.43772502842909 26.271143818321633 0.0 28.5803 0.5 35.49485 42.4094;28.5803;46.2316 26.2988;22.529;31.1788 81.7305;38.8511;81.7848 0 3 0 3 83516;361969;25303 PPARGC1A_33189;FGA_8632;ABCC2_32541 39.073766666666664 42.4094 9.286384399933763 26.668866666666663 26.2988 4.336758237823891 67.45546666666667 81.7305 24.772123070567325 42.4094;28.5803;46.2316 26.2988;22.529;31.1788 81.7305;38.8511;81.7848 0 Exp 2,2(0.67);Linear,1(0.34) 1.7142891943758898 5.158485054969788 1.541895866394043 1.8589661121368408 0.16193732366444075 1.7576230764389038 28.56523346179046 49.58229987154287 21.76136273607149 31.576370597261842 39.423170497213135 95.4877628361202 DOWN 0.0 1.0 0.0 GO:1903428 7 positive regulation of reactive oxygen species biosynthetic process 30 33 4 4 4 4 4 4 158 29 2356 0.94539 0.1542 0.1542 12.12 294515;24890;29184;25698 foxo3;esr1;cd36;ass1 FOXO3_8662;ESR1_33192;CD36_8243;ASS1_33159 27.882425 25.100450000000002 13.1992 14.683619930697153 35.684898884139244 14.834701905516301 20.62875 19.645650000000003 5.6804 13.102957382336761 27.412900038860826 12.530296516977229 42.630975 34.7331 31.9156 17.797126352190507 51.8907128351746 19.764054282652292 0.5 18.2982 2.5 37.46665 13.1992;23.3972;48.1296;26.8037 5.6804;18.3088;37.5433;20.9825 32.7581;31.9156;69.1421;36.7081 1 3 1 29184 CD36_8243 48.1296 48.1296 37.5433 37.5433 69.1421 69.1421 48.1296 37.5433 69.1421 3 294515;24890;25698 FOXO3_8662;ESR1_33192;ASS1_33159 21.133366666666667 23.3972 7.079146211467403 14.990566666666666 18.3088 8.172916887093212 33.793933333333335 32.7581 2.5586572813359565 13.1992;23.3972;26.8037 5.6804;18.3088;20.9825 32.7581;31.9156;36.7081 0 Exp 2,3(0.75);Exp 4,1(0.25) 2.2212551998791565 8.977068066596985 1.8814297914505005 2.6703107357025146 0.3722914385098856 2.212663769721985 13.492477467916792 42.27237253208322 7.787851765309981 33.46964823469003 25.18979117485332 60.07215882514668 DOWN 0.25 0.75 0.0 GO:0044539 8 long-chain fatty acid import into cell 4 4 2 2 2 2 2 2 160 2 2383 0.99904 0.022157 0.022157 50.0 65192;29184 slc27a2;cd36 SLC27A2_9860;CD36_8243 27.875745000000002 27.875745000000002 7.62189 28.64327643133812 26.946430040737564 28.613109445410373 21.521230000000003 21.521230000000003 5.49916 22.658628691291092 20.78608356346484 22.634764712793 41.2673 41.2673 13.3925 39.42092020843756 39.988310463121785 39.37940225053084 0.0 7.62189 0.0 7.62189 7.62189;48.1296 5.49916;37.5433 13.3925;69.1421 2 0 2 65192;29184 SLC27A2_9860;CD36_8243 27.875745000000002 27.875745000000002 28.64327643133812 21.521230000000003 21.521230000000003 22.658628691291092 41.2673 41.2673 39.42092020843756 7.62189;48.1296 5.49916;37.5433 13.3925;69.1421 0 0 Exp 2,1(0.5);Hill,1(0.5) 2.4153379024193806 4.855021715164185 2.18471097946167 2.6703107357025146 0.3433708805804358 2.4275108575820923 -11.821810799999994 67.5733008 -9.882027199999996 52.924487199999994 -13.367307999999994 95.90190799999999 UP 1.0 0.0 0.0 GO:0043066 8 negative regulation of apoptotic process 279 296 29 29 24 25 20 20 142 276 2109 0.67251 0.42154 0.79965 6.76 25106;83516;29441;25513;81819;24314;24567;24516;192235;63868;24471;25675;25661;361969;24360;29496;114851;246142;50559;170465 rgn;ppargc1a;por;pik3r1;pax8;nqo1;mt1;jun;hyou1;hspd1;hspb1;hmgcr;fn1;fga;fabp1;erbb3;cdkn1a;bmf;acot1;acaa2 RGN_9699;PPARGC1A_33189;POR_9531;PIK3R1_32562;PAX8_9432;NQO1_33055;MT1A_9255;JUN_8938;HYOU1_8857;HSPD1_8849;HSPB1_8847;HMGCR_8810;FN1_8655;FGA_8632;FABP1_33091;ERBB3_8571;CDKN1A_8271;BMF_8152;ACOT1_7968;ACAA2_7955 41.983253 37.022999999999996 1.63089 28.688786676212043 44.56636146599408 27.686750221874814 29.512951349999998 26.386200000000002 0.663137 20.97170721423074 31.491201393995357 20.491743746872302 70.95833 70.7963 7.6286 44.852613452332015 70.444490243493 35.987205864438685 13.5 58.2354 77.4407;42.4094;12.4414;18.7324;56.8931;87.2765;12.9315;16.4324;40.1982;42.2579;89.1011;1.63089;59.5777;28.5803;33.8478;60.9984;6.24967;94.8767;31.2018;26.5872 58.7732;26.2988;8.48981;11.6701;45.1162;60.6992;8.91033;10.5224;29.3844;23.9469;60.3265;0.663137;31.0499;22.529;26.4736;41.6036;2.44025;73.1342;26.858;21.3695 89.8047;81.7305;79.2355;41.5978;81.5688;197.117;23.4636;39.929;62.3571;102.383;106.138;7.6286;105.243;38.8511;46.9257;113.972;19.0606;109.848;37.2719;35.0407 9 11 9 25106;81819;24314;63868;24360;29496;246142;50559;170465 RGN_9699;PAX8_9432;NQO1_33055;HSPD1_8849;FABP1_33091;ERBB3_8571;BMF_8152;ACOT1_7968;ACAA2_7955 56.82001111111111 56.8931 25.3196552655464 41.99715555555556 41.6036 18.815179051507272 90.43686666666666 89.8047 50.40035760756067 77.4407;56.8931;87.2765;42.2579;33.8478;60.9984;94.8767;31.2018;26.5872 58.7732;45.1162;60.6992;23.9469;26.4736;41.6036;73.1342;26.858;21.3695 89.8047;81.5688;197.117;102.383;46.9257;113.972;109.848;37.2719;35.0407 11 83516;29441;25513;24567;24516;192235;24471;25675;25661;361969;114851 PPARGC1A_33189;POR_9531;PIK3R1_32562;MT1A_9255;JUN_8938;HYOU1_8857;HSPB1_8847;HMGCR_8810;FN1_8655;FGA_8632;CDKN1A_8271 29.84408727272727 18.7324 26.281336124058118 19.298602454545456 11.6701 17.245258813464652 55.02134545454546 41.5978 34.195366066657726 42.4094;12.4414;18.7324;12.9315;16.4324;40.1982;89.1011;1.63089;59.5777;28.5803;6.24967 26.2988;8.48981;11.6701;8.91033;10.5224;29.3844;60.3265;0.663137;31.0499;22.529;2.44025 81.7305;79.2355;41.5978;23.4636;39.929;62.3571;106.138;7.6286;105.243;38.8511;19.0606 0 Exp 2,7(0.35);Exp 3,1(0.05);Exp 4,2(0.1);Linear,2(0.1);Poly 2,7(0.35);Power,1(0.05) 2.369483739389329 379.214298248291 1.522104263305664 344.14306640625 76.54061585992049 1.7549105286598206 29.40983786879993 54.55666813120007 20.32169541469244 38.70420728530756 51.30080544100455 90.61585455899544 CONFLICT 0.45 0.55 0.0 GO:0051301 3 cell division 78 79 4 4 2 4 2 2 160 77 2308 0.11068 0.96651 0.23634 2.53 257644;290556 zwint;gnl3 ZWINT_10214;GNL3_8735 69.818 69.818 52.0003 25.198032990295097 63.30235849865952 23.452797236833362 46.65575 46.65575 38.9015 10.966165516031612 43.82014758713136 10.2066401933872 159.91215 159.91215 80.8613 111.79478418712118 131.00454694369972 104.0517887521582 52.0003;87.6357 38.9015;54.41 80.8613;238.963 2 0 2 257644;290556 ZWINT_10214;GNL3_8735 69.818 69.818 25.198032990295097 46.65575 46.65575 10.966165516031612 159.91215 159.91215 111.79478418712118 52.0003;87.6357 38.9015;54.41 80.8613;238.963 0 0 Exp 2,2(1) 1.5513530558279416 3.1033202409744263 1.5207922458648682 1.582527995109558 0.04365376693255254 1.5516601204872131 34.895308 104.740692 31.45742 61.854079999999996 4.972484000000009 314.851816 UP 1.0 0.0 0.0 GO:0044772 5 mitotic cell cycle phase transition 44 46 5 5 4 4 3 3 159 43 2342 0.66479 0.56884 1.0 6.52 25112;116636;114851 gadd45a;eif4ebp1;cdkn1a GADD45A_8678;EIF4EBP1_8550;CDKN1A_8271 64.35625666666665 83.9001 6.24967 51.21241255633867 62.151810921339084 53.196073824065195 44.78665 42.4185 2.44025 43.578760360323464 44.82655754364346 45.718087887335294 80.60586666666666 107.32 19.0606 53.454057928779704 77.67490451427398 55.08677753486788 1.5 93.40955 102.919;83.9001;6.24967 89.5012;42.4185;2.44025 115.437;107.32;19.0606 1 2 1 116636 EIF4EBP1_8550 83.9001 83.9001 42.4185 42.4185 107.32 107.32 83.9001 42.4185 107.32 2 25112;114851 GADD45A_8678;CDKN1A_8271 54.584334999999996 54.584334999999996 68.35553877576015 45.970725 45.970725 61.56138812154295 67.2488 67.2488 68.14840598634717 102.919;6.24967 89.5012;2.44025 115.437;19.0606 0 Exp 3,1(0.34);Exp 4,1(0.34);Poly 2,1(0.34) 1.6083534573729237 4.828920602798462 1.522104263305664 1.672852873802185 0.07826239069959588 1.6339634656906128 6.403956323172167 122.30855701016117 -4.527359688966577 94.10065968896657 20.116905787127422 141.09482754620592 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0001505 4 regulation of neurotransmitter levels 102 115 12 12 10 11 9 9 153 106 2279 0.80799 0.30713 0.43888 7.83 29482;25106;29441;24443;24957;24890;497840;29184;25698 slc1a2;rgn;por;hdc;glul;esr1;cps1;cd36;ass1 SLC1A2_33059;RGN_9699;POR_9531;HDC_8788;GLUL_32832;ESR1_33192;CPS1_32421;CD36_8243;ASS1_33159 31.617788888888885 26.4669 12.4414 20.13026384889456 33.918033134843974 21.194305702488606 24.422025555555557 21.0456 8.48981 15.46114361508642 25.977811021841408 16.432535132574735 49.08696666666666 36.7081 24.6773 23.98972641335245 54.69133719629991 23.848886944624567 4.5 26.6353 13.3235;77.4407;12.4414;24.5745;26.4669;23.3972;31.9826;48.1296;26.8037 9.10952;58.7732;8.48981;21.0619;21.0456;18.3088;24.4836;37.5433;20.9825 24.6773;89.8047;79.2355;29.28;35.4303;31.9156;45.5891;69.1421;36.7081 3 6 3 25106;24443;29184 RGN_9699;HDC_8788;CD36_8243 50.04826666666668 48.1296 26.485273963909304 39.126133333333335 37.5433 18.90541081128187 62.742266666666666 69.1421 30.765698879488074 77.4407;24.5745;48.1296 58.7732;21.0619;37.5433 89.8047;29.28;69.1421 6 29482;29441;24957;24890;497840;25698 SLC1A2_33059;POR_9531;GLUL_32832;ESR1_33192;CPS1_32421;ASS1_33159 22.402549999999994 24.93205 7.877936368047168 17.069971666666664 19.645650000000003 6.702209251756973 42.25931666666667 36.0692 19.348885500763775 13.3235;12.4414;26.4669;23.3972;31.9826;26.8037 9.10952;8.48981;21.0456;18.3088;24.4836;20.9825 24.6773;79.2355;35.4303;31.9156;45.5891;36.7081 0 Exp 2,5(0.56);Linear,1(0.12);Poly 2,3(0.34) 2.5825214252891016 34.01266527175903 1.620316982269287 17.513065338134766 5.162416233610901 1.9819281101226807 18.46601650761111 44.76956127016667 14.320745060365754 34.523306050745354 33.41367874327641 64.76025459005693 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0007005 6 mitochondrion organization 66 71 11 11 8 10 7 7 155 64 2321 0.92179 0.16173 0.21423 9.86 171139;83516;303612;25591;24516;63868;170465 timm9;ppargc1a;polg2;parp1;jun;hspd1;acaa2 TIMM9_10020;PPARGC1A_33189;POLG2_9521;PARP1_9425;JUN_8938;HSPD1_8849;ACAA2_7955 171139(0.04986) 36.70798571428571 38.5191 16.4324 15.316290832686247 35.12794656752791 14.130752400280132 24.92027142857143 23.9469 10.5224 9.229060403911529 23.948360610340345 7.890394241967772 68.91405714285715 55.4685 35.0407 37.93793028719662 65.29700328154857 37.90008831662106 2.5 32.7466 38.5191;42.4094;63.7758;26.9741;16.4324;42.2579;26.5872 29.55;26.2988;40.9553;21.799;10.5224;23.9469;21.3695 55.4685;81.7305;132.567;35.2797;39.929;102.383;35.0407 4 3 4 171139;25591;63868;170465 TIMM9_10020;PARP1_9425;HSPD1_8849;ACAA2_7955 33.584575 32.7466 8.004951387474705 24.166349999999998 22.87295 3.762027891532272 57.042975 45.3741 31.706661142560666 38.5191;26.9741;42.2579;26.5872 29.55;21.799;23.9469;21.3695 55.4685;35.2797;102.383;35.0407 3 83516;303612;24516 PPARGC1A_33189;POLG2_9521;JUN_8938 40.87253333333333 42.4094 23.709087925378597 25.9255 26.2988 15.219883878334953 84.74216666666668 81.7305 46.39237397550738 42.4094;63.7758;16.4324 26.2988;40.9553;10.5224 81.7305;132.567;39.929 0 Exp 2,5(0.72);Exp 3,1(0.15);Poly 2,1(0.15) 1.932998723113724 13.801125764846802 1.5504547357559204 2.8333094120025635 0.4460846435081768 1.8086696863174438 25.36151867994239 48.054452748629046 18.083287802779328 31.757255054363537 40.80924507985745 97.01886920585684 CONFLICT 0.5714285714285714 0.42857142857142855 0.0 GO:0006275 8 regulation of DNA replication 31 33 2 2 2 2 2 2 160 31 2354 0.64906 0.63119 1.0 6.06 303612;24516 polg2;jun POLG2_9521;JUN_8938 40.1041 40.1041 16.4324 33.47683918442718 41.21653361895836 33.4398526412247 25.73885 25.73885 10.5224 21.519309961172087 26.453935546927298 21.495534571769824 86.248 86.248 39.929 65.5049579955594 88.42472633552015 65.432585513034 0.5 40.1041 63.7758;16.4324 40.9553;10.5224 132.567;39.929 0 2 0 2 303612;24516 POLG2_9521;JUN_8938 40.1041 40.1041 33.47683918442718 25.73885 25.73885 21.519309961172087 86.248 86.248 65.5049579955594 63.7758;16.4324 40.9553;10.5224 132.567;39.929 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.7514519018809842 3.5289605855941772 1.5504547357559204 1.9785058498382568 0.30267784546207654 1.7644802927970886 -6.292431999999991 86.500632 -4.085392000000002 55.563092 -4.537239999999997 177.03324 DOWN 0.0 1.0 0.0 GO:0006464 6 cellular protein modification process 420 450 23 23 17 20 15 15 147 435 1950 0.0014793 0.99936 0.0027325 3.33 79426;312688;246273;24825;293615;192280;29441;25513;25591;24957;25661;29496;171142;116663;25377 zfp36;usp18;trib3;tf;sirt3;ppp1r3b;por;pik3r1;parp1;glul;fn1;erbb3;ehhadh;dusp6;ambp ZFP36_10204;USP18_10138;TRIB3_10079;TF_10003;SIRT3_9828;PPP1R3B_9545;POR_9531;PIK3R1_32562;PARP1_9425;GLUL_32832;FN1_8655;ERBB3_8571;EHHADH_8534;DUSP6_8506;AMBP_33085 39.62780026666667 26.9741 0.348134 34.638166780714236 40.00564638453652 30.499830074815964 27.272230133333334 21.799 0.118102 24.43010902710407 26.955214942530702 21.08482301907152 65.53865266666666 53.6244 1.15962 49.92789041603879 67.73124042564878 45.744597449889795 0.348134;108.883;108.064;45.1539;2.38018;36.1411;12.4414;18.7324;26.9741;26.4669;59.5777;60.9984;8.62809;62.3934;17.2343 0.118102;73.1414;83.8836;28.132;0.56209;27.0588;8.48981;11.6701;21.799;21.0456;31.0499;41.6036;7.31865;39.0875;14.1233 1.15962;138.144;143.428;61.5341;8.82917;53.6244;79.2355;41.5978;35.2797;35.4303;105.243;113.972;10.3909;133.304;21.9073 6 9 6 312688;24825;293615;25591;29496;171142 USP18_10138;TF_10003;SIRT3_9828;PARP1_9425;ERBB3_8571;EHHADH_8534 42.16961166666667 36.064 39.37827206152063 28.759456666666665 24.9655 26.223539991158077 61.35831166666667 48.4069 54.22426541152232 108.883;45.1539;2.38018;26.9741;60.9984;8.62809 73.1414;28.132;0.56209;21.799;41.6036;7.31865 138.144;61.5341;8.82917;35.2797;113.972;10.3909 9 79426;246273;192280;29441;25513;24957;25661;116663;25377 ZFP36_10204;TRIB3_10079;PPP1R3B_9545;POR_9531;PIK3R1_32562;GLUL_32832;FN1_8655;DUSP6_8506;AMBP_33085 37.933259333333325 26.4669 33.50258715068262 26.280745777777778 21.0456 24.736447054682397 68.32554666666667 53.6244 50.02875682255756 0.348134;108.064;36.1411;12.4414;18.7324;26.4669;59.5777;62.3934;17.2343 0.118102;83.8836;27.0588;8.48981;11.6701;21.0456;31.0499;39.0875;14.1233 1.15962;143.428;53.6244;79.2355;41.5978;35.4303;105.243;133.304;21.9073 0 Exp 2,5(0.34);Hill,2(0.14);Linear,2(0.14);Poly 2,4(0.27);Power,2(0.14) 2.1753078215090795 57.9749276638031 1.5209722518920898 32.73371124267578 7.988866557805614 1.8086696863174438 22.09846930357814 57.157131229755194 14.908889160020614 39.63557110664606 40.27165395590195 90.80565137743139 DOWN 0.4 0.6 0.0 GO:0044238 3 primary metabolic process 1157 1278 155 154 113 135 98 98 64 1180 1205 0.99748 0.0041389 0.007274 7.67 79426;312688;286954;24856;246273;293688;25357;24825;361510;360268;29573;65192;29500;293615;246074;297784;25106;501907;29676;192280;298490;83516;29441;303612;85253;24651;25513;81819;25591;294103;100359982;24539;24516;25685;364070;65164;63868;29540;289456;24464;25675;24443;171155;113965;85255;81869;29328;24957;499914;24384;114860;294515;314322;25661;246186;361969;304929;308441;295143;24890;29496;65030;25315;171142;24330;291075;29740;116663;298541;25428;266682;65210;24894;25146;25423;83842;497840;113936;291394;362866;81718;29184;25698;25028;25377;25284;65183;362732;50681;192272;170570;50559;24158;25287;170465;313917;312382;296925 zfp36;usp18;ugt2b1;ttr;trib3;tm7sf2;thrsp;tf;sult2a2;sult1e1;slc37a4;slc27a2;slc10a2;sirt3;scd;rrs1;rgn;rgd1559459;psmb3;ppp1r3b;ppcs;ppargc1a;por;polg2;plg;pklr;pik3r1;pax8;parp1;papss2;mpc2;lpl;jun;igfbp1;iars2;htra1;hspd1;hsd17b7;hsd17b11;hp;hmgcr;hdc;hadhb;hadh;hacl1;gstm7;gpx4;glul;gins1;gc;gale;foxo3;fos;fn1;fgl1;fga;f5;exosc5;etfdh;esr1;erbb3;ephx2;ephx1;ehhadh;egr1;eci2;eci1;dusp6;dhdds;cyp7a1;cyp3a2;cyp2j4;cyp2a1;cyp17a1;ctsc;crot;cps1;cpb2;cndp2;chpt1;cdo1;cd36;ass1;ampd1;ambp;amacr;aldh3a2;agmo;acox1;acot2;acot12;acot1;acadm;acadl;acaa2;abhd1;abcg2;aass ZFP36_10204;USP18_10138;UGT2B10_33303,UGT2B1_33224;TTR_10102;TRIB3_10079;TM7SF2_10031;THRSP_33314;TF_10003;SULT2A2_33196;SULT1E1_32446;SLC37A4_9871;SLC27A2_9860;SLC10A2_9833;SIRT3_9828;SCD1_9787;RRS1_9755;RGN_9699;RGD1559459_9690;PSMB3_9589;PPP1R3B_9545;PPCS_9540;PPARGC1A_33189;POR_9531;POLG2_9521;PLG_9501;PKLR_9489;PIK3R1_32562;PAX8_9432;PARP1_9425;PAPSS2_33237;MPC2_33219;LPL_32544;JUN_8938;IGFBP1_32306;IARS2_8858;HTRA1_8856;HSPD1_8849;HSD17B7_8834;HSD17B11_8832;HP_8823;HMGCR_8810;HDC_8788;HADHB_8777;HADH_8776;HACL1_8775;GSTM7_8761;GPX4_32827;GLUL_32832;GINS1_8707;GC_32893;GALE_8680;FOXO3_8662;FOS_8657;FN1_8655;FGL1_8640;FGA_8632;F5_33079;EXOSC5_32543;ETFDH_8575;ESR1_33192;ERBB3_8571;EPHX2_33282;EPHX1_8567;EHHADH_8534;EGR1_8533;ECI2_8521;ECI1_8520;DUSP6_8506;DHDDS_8467;CYP7A1_8430;CYP3A2_32374;CYP2J4_32580;CYP2A1_32717;CYP17A1_32365;CTSC_32456;CROT_8384;CPS1_32421;CPB2_8369;CNDP2_8341;CHPT1_33298;CDO1_8275;CD36_8243;ASS1_33159;AMPD1_32743;AMBP_33085;AMACR_8038;ALDH3A2_8024;AGMO_33265;ACOX1_7973;ACOT2_7969;ACOT12_32718;ACOT1_7968;ACADM_7957;ACADL_32776;ACAA2_7955;ABHD1_7949;ABCG2_32656;AASS_7936 34.40454137755103 31.3675 2.52378E-13 24.14132993876555 36.051451518687074 22.729299845223082 24.30520972448982 23.981299999999997 2.52378E-13 16.63099302002809 25.498386603832564 15.6037285291204 59.29143826530612 42.997150000000005 2.52379E-13 55.285528723961875 61.55250026657744 51.57634297638338 62.5 42.28655 0.348134;108.883;47.47345;46.6406;108.064;82.3097;32.2053;45.1539;54.1932;50.1846;39.7166;7.62189;56.585;2.38018;105.46;60.39;77.4407;2.52378E-13;23.7888;36.1411;20.3353;42.4094;12.4414;63.7758;70.7857;23.0963;18.7324;56.8931;26.9741;34.4443;46.8463;74.2041;16.4324;49.0259;24.7304;33.1323;42.2579;0.977494;22.4334;64.9285;1.63089;24.5745;31.8029;33.3125;17.6275;42.3152;45.9204;26.4669;58.9165;42.356;71.148;13.1992;1.28141E-12;59.5777;15.4757;28.5803;10.6089;41.9329;18.1231;23.3972;60.9984;38.7293;12.4747;8.62809;0.750017;10.6467;11.9473;62.3934;47.9438;5.72128;12.8505;17.8395;55.3937;49.6922;56.2386;7.4229;31.9826;25.8316;33.544;16.0559;22.9638;48.1296;26.8037;60.9045;17.2343;2.03774;43.1079;31.5332;23.1906;8.54905;30.3423;31.2018;11.7137;33.4878;26.5872;17.2895;5.21654;27.4644 0.118102;73.1414;34.82915;28.5876;83.8836;51.1696;24.3966;28.132;35.5514;36.5009;22.6911;5.49916;35.2796;0.56209;63.7532;43.109;58.7732;2.52378E-13;19.2724;27.0588;16.7643;26.2988;8.48981;40.9553;46.2356;17.4625;11.6701;45.1162;21.799;25.719;35.8494;49.8682;10.5224;32.6883;19.8021;25.6145;23.9469;0.322682;18.1233;41.6103;0.663137;21.0619;25.5756;25.7336;11.195;31.4035;34.2198;21.0456;44.7208;26.3722;43.2839;5.6804;1.28141E-12;31.0499;10.2138;22.529;2.59129;31.7336;14.869;18.3088;41.6036;29.2097;7.00435;7.31865;0.186019;8.92359;7.15307;39.0875;36.5688;0.985273;7.33176;14.6501;38.7444;35.6654;38.2681;5.75707;24.4836;20.4374;26.3005;10.6021;18.5144;37.5433;20.9825;50.0633;14.1233;1.165;31.8774;24.5474;16.2815;7.19676;24.0157;26.858;8.36151;26.6039;21.3695;14.2242;2.73368;21.7498 1.15962;138.144;76.47475;63.7146;143.428;209.842;46.6068;61.5341;103.141;80.9788;60.0334;13.3925;116.8;8.82917;422.699;104.942;89.8047;2.52379E-13;30.901;53.6244;25.6711;81.7305;79.2355;132.567;150.579;32.9443;41.5978;81.5688;35.2797;51.1014;69.127;155.425;39.929;89.1623;32.7087;46.6629;102.383;5.49472;29.2247;136.455;7.6286;29.28;42.1484;46.9856;37.6534;64.5991;70.4292;35.4303;91.837;78.7583;88.9033;32.7581;1.28142E-12;105.243;30.4106;38.8511;37.5078;62.1373;23.0103;31.9156;113.972;57.2113;23.684;10.3909;4.70178;13.0581;19.001;133.304;71.3742;22.3625;24.0283;22.6149;96.8569;81.6409;102.888;10.316;45.5891;34.8042;46.311;29.905;30.0179;69.1421;36.7081;82.6625;21.9073;3.73641;66.3058;43.8459;33.4539;10.4125;41.1025;37.2719;18.9642;45.3228;35.0407;21.8526;11.386;37.0295 58 41 57 312688;286954;24856;24825;360268;65192;293615;246074;297784;25106;29676;298490;81819;25591;100359982;24539;364070;63868;289456;24443;171155;113965;85255;81869;29328;499914;308441;295143;29496;65030;25315;171142;291075;29740;298541;266682;65210;24894;25146;83842;291394;362866;29184;25028;25284;65183;362732;50681;192272;170570;50559;24158;25287;170465;313917;312382;296925 USP18_10138;UGT2B10_33303,UGT2B1_33224;TTR_10102;TF_10003;SULT1E1_32446;SLC27A2_9860;SIRT3_9828;SCD1_9787;RRS1_9755;RGN_9699;PSMB3_9589;PPCS_9540;PAX8_9432;PARP1_9425;MPC2_33219;LPL_32544;IARS2_8858;HSPD1_8849;HSD17B11_8832;HDC_8788;HADHB_8777;HADH_8776;HACL1_8775;GSTM7_8761;GPX4_32827;GINS1_8707;EXOSC5_32543;ETFDH_8575;ERBB3_8571;EPHX2_33282;EPHX1_8567;EHHADH_8534;ECI2_8521;ECI1_8520;DHDDS_8467;CYP3A2_32374;CYP2J4_32580;CYP2A1_32717;CYP17A1_32365;CROT_8384;CNDP2_8341;CHPT1_33298;CD36_8243;AMPD1_32743;AMACR_8038;ALDH3A2_8024;AGMO_33265;ACOX1_7973;ACOT2_7969;ACOT12_32718;ACOT1_7968;ACADM_7957;ACADL_32776;ACAA2_7955;ABHD1_7949;ABCG2_32656;AASS_7936 34.904211228070174 31.5332 23.209031494166396 25.53274280701754 24.5474 16.009632157557274 57.346960175438596 42.1484 59.71249240923561 108.883;47.47345;46.6406;45.1539;50.1846;7.62189;2.38018;105.46;60.39;77.4407;23.7888;20.3353;56.8931;26.9741;46.8463;74.2041;24.7304;42.2579;22.4334;24.5745;31.8029;33.3125;17.6275;42.3152;45.9204;58.9165;41.9329;18.1231;60.9984;38.7293;12.4747;8.62809;10.6467;11.9473;47.9438;12.8505;17.8395;55.3937;49.6922;7.4229;33.544;16.0559;48.1296;60.9045;2.03774;43.1079;31.5332;23.1906;8.54905;30.3423;31.2018;11.7137;33.4878;26.5872;17.2895;5.21654;27.4644 73.1414;34.82915;28.5876;28.132;36.5009;5.49916;0.56209;63.7532;43.109;58.7732;19.2724;16.7643;45.1162;21.799;35.8494;49.8682;19.8021;23.9469;18.1233;21.0619;25.5756;25.7336;11.195;31.4035;34.2198;44.7208;31.7336;14.869;41.6036;29.2097;7.00435;7.31865;8.92359;7.15307;36.5688;7.33176;14.6501;38.7444;35.6654;5.75707;26.3005;10.6021;37.5433;50.0633;1.165;31.8774;24.5474;16.2815;7.19676;24.0157;26.858;8.36151;26.6039;21.3695;14.2242;2.73368;21.7498 138.144;76.47475;63.7146;61.5341;80.9788;13.3925;8.82917;422.699;104.942;89.8047;30.901;25.6711;81.5688;35.2797;69.127;155.425;32.7087;102.383;29.2247;29.28;42.1484;46.9856;37.6534;64.5991;70.4292;91.837;62.1373;23.0103;113.972;57.2113;23.684;10.3909;13.0581;19.001;71.3742;24.0283;22.6149;96.8569;81.6409;10.316;46.311;29.905;69.1421;82.6625;3.73641;66.3058;43.8459;33.4539;10.4125;41.1025;37.2719;18.9642;45.3228;35.0407;21.8526;11.386;37.0295 41 79426;246273;293688;25357;361510;29573;29500;501907;192280;83516;29441;303612;85253;24651;25513;294103;24516;25685;65164;29540;24464;25675;24957;24384;114860;294515;314322;25661;246186;361969;304929;24890;24330;116663;25428;25423;497840;113936;81718;25698;25377 ZFP36_10204;TRIB3_10079;TM7SF2_10031;THRSP_33314;SULT2A2_33196;SLC37A4_9871;SLC10A2_9833;RGD1559459_9690;PPP1R3B_9545;PPARGC1A_33189;POR_9531;POLG2_9521;PLG_9501;PKLR_9489;PIK3R1_32562;PAPSS2_33237;JUN_8938;IGFBP1_32306;HTRA1_8856;HSD17B7_8834;HP_8823;HMGCR_8810;GLUL_32832;GC_32893;GALE_8680;FOXO3_8662;FOS_8657;FN1_8655;FGL1_8640;FGA_8632;F5_33079;ESR1_33192;EGR1_8533;DUSP6_8506;CYP7A1_8430;CTSC_32456;CPS1_32421;CPB2_8369;CDO1_8275;ASS1_33159;AMBP_33085 33.70987841463419 28.5803 25.65786510787022 22.598639341463453 22.529 17.514750681719867 61.994737073170775 45.5891 49.064188586439144 0.348134;108.064;82.3097;32.2053;54.1932;39.7166;56.585;2.52378E-13;36.1411;42.4094;12.4414;63.7758;70.7857;23.0963;18.7324;34.4443;16.4324;49.0259;33.1323;0.977494;64.9285;1.63089;26.4669;42.356;71.148;13.1992;1.28141E-12;59.5777;15.4757;28.5803;10.6089;23.3972;0.750017;62.3934;5.72128;56.2386;31.9826;25.8316;22.9638;26.8037;17.2343 0.118102;83.8836;51.1696;24.3966;35.5514;22.6911;35.2796;2.52378E-13;27.0588;26.2988;8.48981;40.9553;46.2356;17.4625;11.6701;25.719;10.5224;32.6883;25.6145;0.322682;41.6103;0.663137;21.0456;26.3722;43.2839;5.6804;1.28141E-12;31.0499;10.2138;22.529;2.59129;18.3088;0.186019;39.0875;0.985273;38.2681;24.4836;20.4374;18.5144;20.9825;14.1233 1.15962;143.428;209.842;46.6068;103.141;60.0334;116.8;2.52379E-13;53.6244;81.7305;79.2355;132.567;150.579;32.9443;41.5978;51.1014;39.929;89.1623;46.6629;5.49472;136.455;7.6286;35.4303;78.7583;88.9033;32.7581;1.28142E-12;105.243;30.4106;38.8511;37.5078;31.9156;4.70178;133.304;22.3625;102.888;45.5891;34.8042;30.0179;36.7081;21.9073 0 Exp 2,42(0.43);Exp 3,2(0.03);Exp 4,5(0.06);Hill,11(0.12);Linear,22(0.23);Poly 2,14(0.15);Power,3(0.04) 2.2918115409034097 617.0226721763611 1.5074360370635986 344.14306640625 34.51624787633136 1.8344712257385254 29.624801907713408 39.18428084738864 21.012441100637968 27.597978348341652 48.34546203189096 70.23741449872132 CONFLICT 0.5816326530612245 0.41836734693877553 0.0 GO:0014075 6 response to amine 27 29 3 3 3 3 3 3 159 26 2359 0.8916 0.27947 0.42657 10.34 24330;497840;25698 egr1;cps1;ass1 EGR1_8533;CPS1_32421;ASS1_33159 19.845439 26.8037 0.750017 16.738626207698857 19.135832522884332 17.02009320557722 15.217373 20.9825 0.186019 13.134710792685429 14.657895084003625 13.357681819701307 28.999660000000002 36.7081 4.70178 21.506005431525402 28.100293517616407 21.85634333683723 0.5 13.7768585 1.5 29.39315 0.750017;31.9826;26.8037 0.186019;24.4836;20.9825 4.70178;45.5891;36.7081 0 3 0 3 24330;497840;25698 EGR1_8533;CPS1_32421;ASS1_33159 19.845439 26.8037 16.738626207698857 15.217373 20.9825 13.134710792685429 28.999660000000002 36.7081 21.506005431525402 0.750017;31.9826;26.8037 0.186019;24.4836;20.9825 4.70178;45.5891;36.7081 0 Exp 2,2(0.67);Hill,1(0.34) 2.4382558866716906 7.9261908531188965 1.8264755010604858 4.21828556060791 1.3653247611727641 1.8814297914505005 0.9039003201162608 38.78697767988375 0.354048528705766 30.080697471294236 4.663323870833899 53.335996129166105 DOWN 0.0 1.0 0.0 GO:0001937 8 negative regulation of endothelial cell proliferation 16 17 1 1 1 1 1 1 161 16 2369 0.705 0.67399 1.0 5.88 24794 serpina3c SERPINA3C_32925 29.766 29.766 29.766 29.766 23.347 23.347 23.347 23.347 40.8256 40.8256 40.8256 40.8256 0.0 29.766 29.766 23.347 40.8256 0 1 0 1 24794 SERPINA3C_32925 29.766 29.766 23.347 23.347 40.8256 40.8256 29.766 23.347 40.8256 0 Linear,1(1) 1.6202073097229004 1.6202073097229004 1.6202073097229004 1.6202073097229004 0.0 1.6202073097229004 29.766 29.766 23.347 23.347 40.8256 40.8256 DOWN 0.0 1.0 0.0 GO:0006108 8 malate metabolic process 2 2 1 1 1 1 1 1 161 1 2384 0.99598 0.12319 0.12319 50.0 24552 me1 ME1_9215 80.7944 80.7944 80.7944 80.7944 59.856 59.856 59.856 59.856 94.0621 94.0621 94.0621 94.0621 0.0 80.7944 0.0 80.7944 80.7944 59.856 94.0621 0 1 0 1 24552 ME1_9215 80.7944 80.7944 59.856 59.856 94.0621 94.0621 80.7944 59.856 94.0621 0 Poly 2,1(1) 2.376685380935669 2.376685380935669 2.376685380935669 2.376685380935669 0.0 2.376685380935669 80.7944 80.7944 59.856 59.856 94.0621 94.0621 DOWN 0.0 1.0 0.0 GO:1904880 5 response to hydrogen sulfide 3 3 1 1 1 1 1 1 161 2 2383 0.98844 0.179 0.179 33.33 24314 nqo1 NQO1_33055 87.2765 87.2765 87.2765 87.2765 60.6992 60.6992 60.6992 60.6992 197.117 197.117 197.117 197.117 0.0 87.2765 0.0 87.2765 87.2765 60.6992 197.117 1 0 1 24314 NQO1_33055 87.2765 87.2765 60.6992 60.6992 197.117 197.117 87.2765 60.6992 197.117 0 0 Exp 2,1(1) 1.576730489730835 1.576730489730835 1.576730489730835 1.576730489730835 0.0 1.576730489730835 87.2765 87.2765 60.6992 60.6992 197.117 197.117 UP 1.0 0.0 0.0 GO:0048638 5 regulation of developmental growth 94 100 7 7 5 6 5 5 157 95 2290 0.3789 0.77491 0.83311 5.0 29441;29455;25661;116663;114851 por;gdf15;fn1;dusp6;cdkn1a POR_9531;GDF15_33113;FN1_8655;DUSP6_8506;CDKN1A_8271 49.162234 59.5777 6.24967 40.644715067168086 47.81901879997829 40.71724412361141 33.283232 31.0499 2.44025 32.846208190670495 31.76544451011772 32.76584781808072 92.49902 105.243 19.0606 46.08605536604322 87.38046166928876 47.25355305099554 4.0 105.149 12.4414;105.149;59.5777;62.3934;6.24967 8.48981;85.3487;31.0499;39.0875;2.44025 79.2355;125.652;105.243;133.304;19.0606 0 5 0 5 29441;29455;25661;116663;114851 POR_9531;GDF15_33113;FN1_8655;DUSP6_8506;CDKN1A_8271 49.162234 59.5777 40.644715067168086 33.283232 31.0499 32.846208190670495 92.49902 105.243 46.08605536604322 12.4414;105.149;59.5777;62.3934;6.24967 8.48981;85.3487;31.0499;39.0875;2.44025 79.2355;125.652;105.243;133.304;19.0606 0 Exp 2,1(0.2);Exp 4,1(0.2);Poly 2,2(0.4);Power,1(0.2) 1.687926548391084 8.479592204093933 1.522104263305664 1.9819281101226807 0.1876737966683301 1.6357084512710571 13.535570440011284 84.78889755998871 4.492261107559749 62.07420289244025 52.102811375589695 132.89522862441027 DOWN 0.0 1.0 0.0 GO:0032869 7 cellular response to insulin stimulus 59 62 16 15 11 12 8 8 154 54 2331 0.98507 0.040168 0.056319 12.9 246273;24651;25513;25591;29496;24330;29184;25373 trib3;pklr;pik3r1;parp1;erbb3;egr1;cd36;ahsg TRIB3_10079;PKLR_9489;PIK3R1_32562;PARP1_9425;ERBB3_8571;EGR1_8533;CD36_8243;AHSG_8003 37.393352125 25.0352 0.750017 34.424462052703895 37.325395228609324 31.31006486253541 28.056177375 19.63075 0.186019 26.463188641822182 28.105911110404215 23.871314788688874 57.0611475 38.43875 4.70178 48.718423788592624 56.97092439998201 45.86766267457803 2.5 20.91435 5.5 54.564 108.064;23.0963;18.7324;26.9741;60.9984;0.750017;48.1296;12.402 83.8836;17.4625;11.6701;21.799;41.6036;0.186019;37.5433;10.3013 143.428;32.9443;41.5978;35.2797;113.972;4.70178;69.1421;15.4235 3 5 3 25591;29496;29184 PARP1_9425;ERBB3_8571;CD36_8243 45.36736666666667 48.1296 17.17951388611834 33.64863333333333 37.5433 10.460968722988024 72.79793333333333 69.1421 39.47332463630765 26.9741;60.9984;48.1296 21.799;41.6036;37.5433 35.2797;113.972;69.1421 5 246273;24651;25513;24330;25373 TRIB3_10079;PKLR_9489;PIK3R1_32562;EGR1_8533;AHSG_8003 32.6089434 18.7324 43.01112112183392 24.7007038 11.6701 33.664209603456044 47.619076 32.9443 55.47387705776369 108.064;23.0963;18.7324;0.750017;12.402 83.8836;17.4625;11.6701;0.186019;10.3013 143.428;32.9443;41.5978;4.70178;15.4235 0 Exp 2,4(0.5);Hill,1(0.13);Linear,1(0.13);Poly 2,2(0.25) 2.3557206910050197 19.977473974227905 1.6013026237487793 4.21828556060791 0.9444751218704923 2.2737234830856323 13.538416979957418 61.24828727004258 9.71812323735774 46.394231512642264 23.301002226958836 90.82129277304116 DOWN 0.375 0.625 0.0 GO:1901387 8 positive regulation of voltage-gated calcium channel activity 1 1 1 1 1 1 1 1 161 0 2385 1.0 0.063604 0.063604 100.0 362895 stac3 STAC3_9953 63.2393 63.2393 63.2393 63.2393 42.7031 42.7031 42.7031 42.7031 121.52 121.52 121.52 121.52000000000001 0.0 63.2393 0.0 63.2393 63.2393 42.7031 121.52 0 1 0 1 362895 STAC3_9953 63.2393 63.2393 42.7031 42.7031 121.52 121.52 63.2393 42.7031 121.52 0 Linear,1(1) 2.879150867462158 2.879150867462158 2.879150867462158 2.879150867462158 0.0 2.879150867462158 63.2393 63.2393 42.7031 42.7031 121.52 121.52 DOWN 0.0 1.0 0.0 GO:0043410 8 positive regulation of MAPK cascade 143 153 10 10 10 9 9 9 153 144 2241 0.48612 0.64925 1.0 5.88 24825;24516;25675;29455;299626;25112;361969;24890;29184 tf;jun;hmgcr;gdf15;gadd45b;gadd45a;fga;esr1;cd36 TF_10003;JUN_8938;HMGCR_8810;GDF15_33113;GADD45B_8679;GADD45A_8678;FGA_8632;ESR1_33192;CD36_8243 53.08436555555556 45.1539 1.63089 41.22090158877141 60.225534318503826 36.89399091241681 38.36241522222222 28.132 0.663137 31.589773230432264 46.76875376395579 31.605422192987113 66.61372222222222 61.5341 7.6286 41.684895440458334 75.67460695057281 37.344362338706986 6.5 104.03399999999999 45.1539;16.4324;1.63089;105.149;106.367;102.919;28.5803;23.3972;48.1296 28.132;10.5224;0.663137;85.3487;52.7132;89.5012;22.529;18.3088;37.5433 61.5341;39.929;7.6286;125.652;109.434;115.437;38.8511;31.9156;69.1421 3 6 3 24825;299626;29184 TF_10003;GADD45B_8679;CD36_8243 66.55016666666667 48.1296 34.514473198114025 39.462833333333336 37.5433 12.402512024720357 80.03673333333333 69.1421 25.74140403325611 45.1539;106.367;48.1296 28.132;52.7132;37.5433 61.5341;109.434;69.1421 6 24516;25675;29455;25112;361969;24890 JUN_8938;HMGCR_8810;GDF15_33113;GADD45A_8678;FGA_8632;ESR1_33192 46.351465 25.988750000000003 45.595677435486685 37.81220616666666 20.4189 39.16686465079312 59.90221666666667 39.39005 48.50774531360602 16.4324;1.63089;105.149;102.919;28.5803;23.3972 10.5224;0.663137;85.3487;89.5012;22.529;18.3088 39.929;7.6286;125.652;115.437;38.8511;31.9156 0 Exp 2,2(0.23);Exp 4,1(0.12);Linear,1(0.12);Poly 2,4(0.45);Power,1(0.12) 1.865953082559058 17.11123502254486 1.541895866394043 2.6703107357025146 0.40727465163436777 1.8344712257385254 26.153376517558236 80.01535459355287 17.723763378339807 59.00106706610464 39.3795905344561 93.84785390998832 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0006805 4 xenobiotic metabolic process 43 62 11 11 10 9 8 8 154 54 2331 0.98507 0.040168 0.056319 12.9 286954;501907;81869;65210;24894;25146;81718;25303 ugt2b1;rgd1559459;gstm7;cyp2j4;cyp2a1;cyp17a1;cdo1;abcc2 UGT2B10_33303,UGT2B1_33224;RGD1559459_9690;GSTM7_8761;CYP2J4_32580;CYP2A1_32717;CYP17A1_32365;CDO1_8275;ABCC2_32541 35.238681250000035 44.273399999999995 2.52378E-13 19.386699438420845 34.63670213834691 17.111044184780756 25.623218750000035 31.291150000000002 2.52378E-13 13.360550055077782 25.580989746932442 11.604773685367016 56.74865625000003 70.536925 2.52379E-13 34.653196889850385 54.375064476009264 31.355459621953358 2.5 32.6395 5.5 48.582825 47.47345;2.52378E-13;42.3152;17.8395;55.3937;49.6922;22.9638;46.2316 34.82915;2.52378E-13;31.4035;14.6501;38.7444;35.6654;18.5144;31.1788 76.47475;2.52379E-13;64.5991;22.6149;96.8569;81.6409;30.0179;81.7848 6 3 5 286954;81869;65210;24894;25146 UGT2B10_33303,UGT2B1_33224;GSTM7_8761;CYP2J4_32580;CYP2A1_32717;CYP17A1_32365 42.54281 47.47345 14.584886811713679 31.058510000000002 34.82915 9.537675337864034 68.43731 76.47475 28.111534290313998 47.47345;42.3152;17.8395;55.3937;49.6922 34.82915;31.4035;14.6501;38.7444;35.6654 76.47475;64.5991;22.6149;96.8569;81.6409 3 501907;81718;25303 RGD1559459_9690;CDO1_8275;ABCC2_32541 23.065133333333417 22.9638 23.11596658098743 16.56440000000008 18.5144 15.680601626213063 37.26756666666675 30.0179 41.3715678678404 2.52378E-13;22.9638;46.2316 2.52378E-13;18.5144;31.1788 2.52379E-13;30.0179;81.7848 0 Exp 2,3(0.34);Hill,1(0.12);Linear,5(0.56) 1.9315026382472371 18.039931416511536 1.6167030334472656 3.8079800605773926 0.6885599802767146 1.7730062007904053 21.804383945021883 48.67297855497819 16.36482991655878 34.88160758344128 32.73521594960636 80.76209655039372 UP 0.625 0.375 0.0 GO:0032770 7 positive regulation of monooxygenase activity 13 15 3 3 2 3 2 2 160 13 2372 0.93468 0.24652 0.24652 13.33 29441;24890 por;esr1 POR_9531;ESR1_33192 17.9193 17.9193 12.4414 7.7469204733235815 14.828970400508583 6.396444539977999 13.399305000000002 13.399305000000002 8.48981 6.943074413402896 10.629638208518754 5.732728324138686 55.57555 55.57555 31.9156 33.460222175069326 68.92319121424032 27.627294765083796 0.0 12.4414 0.5 17.9193 12.4414;23.3972 8.48981;18.3088 79.2355;31.9156 0 2 0 2 29441;24890 POR_9531;ESR1_33192 17.9193 17.9193 7.7469204733235815 13.399305000000002 13.399305000000002 6.943074413402896 55.57555 55.57555 33.460222175069326 12.4414;23.3972 8.48981;18.3088 79.2355;31.9156 0 Exp 2,1(0.5);Poly 2,1(0.5) 2.1977105063090625 4.418914318084717 1.9819281101226807 2.436986207962036 0.32177466681605965 2.2094571590423584 7.1826159999999994 28.655984 3.7766948000000014 23.021915200000002 9.202047999999998 101.949052 DOWN 0.0 1.0 0.0 GO:0042771 8 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 12 12 3 3 3 2 2 2 160 10 2375 0.96369 0.17482 0.17482 16.67 140942;114851 ddit4;cdkn1a DDIT4_8450;CDKN1A_8271 46.895885 46.895885 6.24967 57.48242851213274 20.51385326182618 43.72878217358024 27.842775 27.842775 2.44025 35.924595373521605 11.354887486248625 27.32902638988467 132.2763 132.2763 19.0606 160.11117841356358 58.79196226622662 121.8018623364908 0.0 6.24967 0.5 46.895885 87.5421;6.24967 53.2453;2.44025 245.492;19.0606 0 2 0 2 140942;114851 DDIT4_8450;CDKN1A_8271 46.895885 46.895885 57.48242851213274 27.842775 27.842775 35.924595373521605 132.2763 132.2763 160.11117841356358 87.5421;6.24967 53.2453;2.44025 245.492;19.0606 0 Exp 4,1(0.5);Linear,1(0.5) 1.5930089147423125 3.1893208026885986 1.522104263305664 1.6672165393829346 0.10260987444765239 1.5946604013442993 -32.77069640000001 126.5624664 -21.946173999999996 77.63172399999999 -89.62647199999998 354.17907199999996 DOWN 0.0 1.0 0.0 GO:0046395 6 carboxylic acid catabolic process 80 87 31 31 19 28 17 17 145 70 2315 1.0 1.9835E-5 1.9835E-5 19.54 65192;24443;171155;113965;85255;295143;171142;291075;29740;83842;81718;50681;192272;24158;25287;170465;296925 slc27a2;hdc;hadhb;hadh;hacl1;etfdh;ehhadh;eci2;eci1;crot;cdo1;acox1;acot2;acadm;acadl;acaa2;aass SLC27A2_9860;HDC_8788;HADHB_8777;HADH_8776;HACL1_8775;ETFDH_8575;EHHADH_8534;ECI2_8521;ECI1_8520;CROT_8384;CDO1_8275;ACOX1_7973;ACOT2_7969;ACADM_7957;ACADL_32776;ACAA2_7955;AASS_7936 19.156701764705883 18.1231 7.4229 9.445074614185984 18.978204174888763 9.42904159097396 14.892000588235293 14.869 5.49916 7.709689997025229 14.751354020893789 7.533642405228649 26.792805882352937 29.28 10.316 12.874321995471789 26.8023287250919 12.940537376413982 3.5 9.637395 7.5 17.875300000000003 7.62189;24.5745;31.8029;33.3125;17.6275;18.1231;8.62809;10.6467;11.9473;7.4229;22.9638;23.1906;8.54905;11.7137;33.4878;26.5872;27.4644 5.49916;21.0619;25.5756;25.7336;11.195;14.869;7.31865;8.92359;7.15307;5.75707;18.5144;16.2815;7.19676;8.36151;26.6039;21.3695;21.7498 13.3925;29.28;42.1484;46.9856;37.6534;23.0103;10.3909;13.0581;19.001;10.316;30.0179;33.4539;10.4125;18.9642;45.3228;35.0407;37.0295 16 1 16 65192;24443;171155;113965;85255;295143;171142;291075;29740;83842;50681;192272;24158;25287;170465;296925 SLC27A2_9860;HDC_8788;HADHB_8777;HADH_8776;HACL1_8775;ETFDH_8575;EHHADH_8534;ECI2_8521;ECI1_8520;CROT_8384;ACOX1_7973;ACOT2_7969;ACADM_7957;ACADL_32776;ACAA2_7955;AASS_7936 18.918758124999997 17.875300000000003 9.702065346088757 14.665600625 13.032 7.903953563509398 26.5912375 26.14515 13.268808940311871 7.62189;24.5745;31.8029;33.3125;17.6275;18.1231;8.62809;10.6467;11.9473;7.4229;23.1906;8.54905;11.7137;33.4878;26.5872;27.4644 5.49916;21.0619;25.5756;25.7336;11.195;14.869;7.31865;8.92359;7.15307;5.75707;16.2815;7.19676;8.36151;26.6039;21.3695;21.7498 13.3925;29.28;42.1484;46.9856;37.6534;23.0103;10.3909;13.0581;19.001;10.316;33.4539;10.4125;18.9642;45.3228;35.0407;37.0295 1 81718 CDO1_8275 22.9638 22.9638 18.5144 18.5144 30.0179 30.0179 22.9638 18.5144 30.0179 0 Exp 2,5(0.3);Hill,2(0.12);Linear,6(0.36);Poly 2,3(0.18);Power,1(0.06) 3.82755586629765 109.44220173358917 1.693061113357544 32.73371124267578 8.263240938962156 2.359739303588867 14.666798297575745 23.646605231836027 11.227046602996133 18.556954573474457 20.672741687455062 32.91287007725082 UP 0.9411764705882353 0.058823529411764705 0.0 GO:1990542 5 mitochondrial transmembrane transport 12 12 2 2 2 2 2 2 160 10 2375 0.96369 0.17482 0.17482 16.67 100359982;63868 mpc2;hspd1 MPC2_33219;HSPD1_8849 44.552099999999996 44.552099999999996 42.2579 3.244488754796457 44.22466307290208 3.2112734853240466 29.89815 29.89815 23.9469 8.41633846307289 29.048765023802858 8.330176675762726 85.755 85.755 69.127 23.515543115139813 88.12821123868197 23.27480407722448 0.0 42.2579 0.5 44.552099999999996 46.8463;42.2579 35.8494;23.9469 69.127;102.383 2 0 2 100359982;63868 MPC2_33219;HSPD1_8849 44.552099999999996 44.552099999999996 3.244488754796457 29.89815 29.89815 8.41633846307289 85.755 85.755 23.515543115139813 46.8463;42.2579 35.8494;23.9469 69.127;102.383 0 0 Exp 2,1(0.5);Exp 3,1(0.5) 2.0806036850925493 4.174230217933655 1.9223796129226685 2.2518506050109863 0.2329711727099089 2.0871151089668274 40.055468 49.048731999999994 18.2337 41.5626 53.16412 118.34588 UP 1.0 0.0 0.0 GO:0033198 5 response to ATP 13 13 2 2 2 2 2 2 160 11 2374 0.95495 0.19842 0.19842 15.38 24651;63868 pklr;hspd1 PKLR_9489;HSPD1_8849 32.677099999999996 32.677099999999996 23.0963 13.549297298384165 34.1800415989416 13.381546636332503 20.7047 20.7047 17.4625 4.585163211926048 21.21330442260442 4.528395384969649 67.66364999999999 67.66364999999999 32.9443 49.10057564677833 73.11007988092986 48.49267297179266 0.0 23.0963 0.5 32.677099999999996 23.0963;42.2579 17.4625;23.9469 32.9443;102.383 1 1 1 63868 HSPD1_8849 42.2579 42.2579 23.9469 23.9469 102.383 102.383 42.2579 23.9469 102.383 1 24651 PKLR_9489 23.0963 23.0963 17.4625 17.4625 32.9443 32.9443 23.0963 17.4625 32.9443 0 Exp 2,1(0.5);Exp 3,1(0.5) 2.4642891271516016 4.948619604110718 2.2518506050109863 2.6967689990997314 0.3146048135347804 2.474309802055359 13.898731999999995 51.455467999999996 14.349987999999998 27.059412000000002 -0.3862760000000094 135.713576 CONFLICT 0.5 0.5 0.0 GO:0010046 5 response to mycotoxin 7 7 3 3 3 2 2 2 160 5 2380 0.99269 0.068343 0.068343 28.57 24330;25698 egr1;ass1 EGR1_8533;ASS1_33159 13.7768585 13.7768585 0.750017 18.42273592418467 13.024409492518599 18.39197759661872 10.584259500000002 10.584259500000002 0.186019 14.705332739917193 9.983642248014714 14.680780933755392 20.70494 20.70494 4.70178 22.631885912826622 19.780574576611222 22.594100050661154 0.0 0.750017 0.0 0.750017 0.750017;26.8037 0.186019;20.9825 4.70178;36.7081 0 2 0 2 24330;25698 EGR1_8533;ASS1_33159 13.7768585 13.7768585 18.42273592418467 10.584259500000002 10.584259500000002 14.705332739917193 20.70494 20.70494 22.631885912826622 0.750017;26.8037 0.186019;20.9825 4.70178;36.7081 0 Exp 2,1(0.5);Hill,1(0.5) 2.8171631338233145 6.099715352058411 1.8814297914505005 4.21828556060791 1.6524065610261096 3.0498576760292053 -11.755750839999997 39.309467839999996 -9.796291879999997 30.964810879999995 -10.661253599999998 52.071133599999996 DOWN 0.0 1.0 0.0 GO:0051641 3 cellular localization 308 325 14 13 11 13 11 11 151 314 2071 0.0089421 0.99604 0.01994 3.38 171139;297784;308821;25513;25493;192235;63868;24471;85255;24890;114851 timm9;rrs1;rab30;pik3r1;nfkbia;hyou1;hspd1;hspb1;hacl1;esr1;cdkn1a TIMM9_10020;RRS1_9755;RAB30_9639;PIK3R1_32562;NFKBIA_9307;HYOU1_8857;HSPD1_8849;HSPB1_8847;HACL1_8775;ESR1_33192;CDKN1A_8271 171139(0.04986) 33.037592818181814 26.4203 0.520151 25.320778756511295 35.81751501398528 28.694210723302064 22.827604727272732 21.0125 0.160202 17.66327860345484 24.043006485176463 19.970901118715165 54.523371818181815 41.5978 2.88499 35.79553765154166 59.44424841280958 37.997931653838634 38.5191;60.39;26.4203;18.7324;0.520151;40.1982;42.2579;89.1011;17.6275;23.3972;6.24967 29.55;43.109;21.0125;11.6701;0.160202;29.3844;23.9469;60.3265;11.195;18.3088;2.44025 55.4685;104.942;35.3561;41.5978;2.88499;62.3571;102.383;106.138;37.6534;31.9156;19.0606 5 6 5 171139;297784;308821;63868;85255 TIMM9_10020;RRS1_9755;RAB30_9639;HSPD1_8849;HACL1_8775 37.04296000000001 38.5191 16.311497921343694 25.76268 23.9469 11.761347477521442 67.1606 55.4685 34.23068039865698 38.5191;60.39;26.4203;42.2579;17.6275 29.55;43.109;21.0125;23.9469;11.195 55.4685;104.942;35.3561;102.383;37.6534 6 25513;25493;192235;24471;24890;114851 PIK3R1_32562;NFKBIA_9307;HYOU1_8857;HSPB1_8847;ESR1_33192;CDKN1A_8271 29.699786833333334 21.064799999999998 32.249334835152986 20.38170866666667 14.989450000000001 22.30528705381777 43.99234833333333 36.7567 36.50297199128335 18.7324;0.520151;40.1982;89.1011;23.3972;6.24967 11.6701;0.160202;29.3844;60.3265;18.3088;2.44025 41.5978;2.88499;62.3571;106.138;31.9156;19.0606 0 Exp 2,4(0.37);Exp 3,1(0.1);Exp 4,2(0.19);Linear,1(0.1);Poly 2,3(0.28) 1.9269943281409627 21.654380798339844 1.522104263305664 2.945132255554199 0.44815037819126335 1.7180453538894653 18.07396880286351 48.00121683350013 12.389274119769272 33.26593533477619 33.36956087126925 75.67718276509439 CONFLICT 0.45454545454545453 0.5454545454545454 0.0 GO:0010906 6 regulation of glucose metabolic process 37 37 5 5 5 4 4 4 158 33 2352 0.91802 0.20594 0.29228 10.81 25106;192280;246186;24158 rgn;ppp1r3b;fgl1;acadm RGN_9699;PPP1R3B_9545;FGL1_8640;ACADM_7957 35.192800000000005 25.8084 11.7137 30.1430837646051 33.1946882034632 26.949410437523827 26.101827500000002 18.636300000000002 8.36151 23.348680621119154 24.4541794484127 20.998102111536596 48.200975 42.0175 18.9642 31.260038001936277 47.429315357142855 27.370970379626446 0.5 13.5947 2.5 56.79090000000001 77.4407;36.1411;15.4757;11.7137 58.7732;27.0588;10.2138;8.36151 89.8047;53.6244;30.4106;18.9642 2 2 2 25106;24158 RGN_9699;ACADM_7957 44.577200000000005 44.577200000000005 46.47600740704821 33.567355 33.567355 35.646447850074075 54.38445 54.38445 50.09179793264562 77.4407;11.7137 58.7732;8.36151 89.8047;18.9642 2 192280;246186 PPP1R3B_9545;FGL1_8640 25.8084 25.8084 14.612644475932493 18.636300000000002 18.636300000000002 11.911213729087391 42.0175 42.0175 16.414635397108288 36.1411;15.4757 27.0588;10.2138 53.6244;30.4106 0 Exp 2,1(0.25);Poly 2,3(0.75) 1.6959613886338925 6.804168224334717 1.511321783065796 1.8798987865447998 0.15099925176149862 1.7064738273620605 5.652577910686997 64.73302208931301 3.2201204913032306 48.98353450869678 17.566137758102453 78.83581224189754 CONFLICT 0.5 0.5 0.0 GO:0009409 4 response to cold 23 27 7 7 6 7 6 6 156 21 2364 0.99889 0.0058302 0.0058302 22.22 83516;24539;63868;314322;24158;25287 ppargc1a;lpl;hspd1;fos;acadm;acadl PPARGC1A_33189;LPL_32544;HSPD1_8849;FOS_8657;ACADM_7957;ACADL_32776 34.01215000000021 37.87285 1.28141E-12 26.108317480737494 43.79736403167461 26.379723201359223 22.513218333333544 25.12285 1.28141E-12 17.254162504358337 28.519797413134114 17.750815407007963 67.30425000000021 63.526650000000004 1.28142E-12 57.53904520819725 90.35454596218183 58.29631011084976 0.5 5.85685000000064 1.5 22.600749999999998 42.4094;74.2041;42.2579;1.28141E-12;11.7137;33.4878 26.2988;49.8682;23.9469;1.28141E-12;8.36151;26.6039 81.7305;155.425;102.383;1.28142E-12;18.9642;45.3228 4 2 4 24539;63868;24158;25287 LPL_32544;HSPD1_8849;ACADM_7957;ACADL_32776 40.415875 37.87285 25.92842891298725 27.1951275 25.275399999999998 17.12380308785673 80.52375 73.8529 60.873390845891485 74.2041;42.2579;11.7137;33.4878 49.8682;23.9469;8.36151;26.6039 155.425;102.383;18.9642;45.3228 2 83516;314322 PPARGC1A_33189;FOS_8657 21.20470000000064 21.20470000000064 29.987974326051862 13.149400000000641 13.149400000000641 18.59605981706787 40.86525000000064 40.86525000000064 57.79219077976622 42.4094;1.28141E-12 26.2988;1.28141E-12 81.7305;1.28142E-12 0 Exp 2,3(0.5);Exp 3,1(0.17);Hill,1(0.17);Poly 2,1(0.17) 1.8287391445364496 11.045828342437744 1.559399127960205 2.2518506050109863 0.23755870988849298 1.8224246501922607 13.121145082338426 54.90315491766199 8.707012935585192 36.319423731081905 21.263424991308092 113.34507500869236 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0045471 5 response to ethanol 109 117 18 18 12 17 11 11 151 106 2279 0.93536 0.1205 0.17236 9.4 286954;25513;24314;25493;81678;25675;116636;24330;25428;81718;54232 ugt2b1;pik3r1;nqo1;nfkbia;itpr2;hmgcr;eif4ebp1;egr1;cyp7a1;cdo1;car3 UGT2B10_33303,UGT2B1_33224;PIK3R1_32562;NQO1_33055;NFKBIA_9307;ITPR2_8931;HMGCR_8810;EIF4EBP1_8550;EGR1_8533;CYP7A1_8430;CDO1_8275;CAR3_8196 32.24929890909091 22.9638 0.520151 32.106581470968344 37.37861834888458 27.374158906970912 20.30578009090909 18.5144 0.160202 20.164050784485255 23.505245771181453 15.255278039686685 55.587610909090905 41.5978 2.88499 57.74944304641014 55.94993541156257 40.1746897045595 4.5 20.8481 47.47345;18.7324;87.2765;0.520151;31.8111;1.63089;83.9001;0.750017;5.72128;22.9638;53.9626 34.82915;11.6701;60.6992;0.160202;24.7342;0.663137;42.4185;0.186019;0.985273;18.5144;28.5034 76.47475;41.5978;197.117;2.88499;44.3296;7.6286;107.32;4.70178;22.3625;30.0179;77.0288 4 8 3 286954;24314;116636 UGT2B10_33303,UGT2B1_33224;NQO1_33055;EIF4EBP1_8550 72.88335 83.9001 22.070280531690138 45.98228333333333 42.4185 13.298130901966399 126.97058333333332 107.32 62.67573047257472 47.47345;87.2765;83.9001 34.82915;60.6992;42.4185 76.47475;197.117;107.32 8 25513;25493;81678;25675;24330;25428;81718;54232 PIK3R1_32562;NFKBIA_9307;ITPR2_8931;HMGCR_8810;EGR1_8533;CYP7A1_8430;CDO1_8275;CAR3_8196 17.01152975 12.22684 18.98584426160904 10.677091375 6.3276864999999995 11.908383853665379 28.818996249999998 26.1902 25.28249320511948 18.7324;0.520151;31.8111;1.63089;0.750017;5.72128;22.9638;53.9626 11.6701;0.160202;24.7342;0.663137;0.186019;0.985273;18.5144;28.5034 41.5978;2.88499;44.3296;7.6286;4.70178;22.3625;30.0179;77.0288 0 Exp 2,3(0.25);Exp 3,1(0.09);Exp 4,2(0.17);Hill,2(0.17);Linear,2(0.17);Poly 2,2(0.17) 2.1784352291534925 28.45992600917816 1.576730489730835 4.560328960418701 1.1354443916484356 1.813806176185608 13.275521752840838 51.22307606534097 8.389587565146753 32.22197261667142 21.4598709548723 89.71535086330951 DOWN 0.2727272727272727 0.7272727272727273 0.0 GO:0032101 5 regulation of response to external stimulus 254 266 25 24 20 23 20 20 142 246 2139 0.83016 0.24148 0.42479 7.52 79426;312688;85253;25493;24539;288001;65164;63868;24471;25675;29328;25661;361969;80841;24890;25423;113936;114851;29184;25373 zfp36;usp18;plg;nfkbia;lpl;kng1;htra1;hspd1;hspb1;hmgcr;gpx4;fn1;fga;fabp7;esr1;ctsc;cpb2;cdkn1a;cd36;ahsg ZFP36_10204;USP18_10138;PLG_9501;NFKBIA_9307;LPL_32544;KNG1L1_34113;HTRA1_8856;HSPD1_8849;HSPB1_8847;HMGCR_8810;GPX4_32827;FN1_8655;FGA_8632;FABP7_8592;ESR1_33192;CTSC_32456;CPB2_8369;CDKN1A_8271;CD36_8243;AHSG_8003 38.80784225 30.8563 0.348134 30.467971886062553 46.8648509621576 27.743887959883647 26.457529549999997 23.237949999999998 0.118102 20.281382782550025 31.426712875388485 18.434933708324625 63.32623050000001 42.757000000000005 1.15962 50.13071714314902 79.81167440975261 48.708275555093415 12.5 47.025000000000006 0.348134;108.883;70.7857;0.520151;74.2041;24.3655;33.1323;42.2579;89.1011;1.63089;45.9204;59.5777;28.5803;24.601;23.3972;56.2386;25.8316;6.24967;48.1296;12.402 0.118102;73.1414;46.2356;0.160202;49.8682;19.538;25.6145;23.9469;60.3265;0.663137;34.2198;31.0499;22.529;14.4402;18.3088;38.2681;20.4374;2.44025;37.5433;10.3013 1.15962;138.144;150.579;2.88499;155.425;32.1467;46.6629;102.383;106.138;7.6286;70.4292;105.243;38.8511;35.6155;31.9156;102.888;34.8042;19.0606;69.1421;15.4235 6 14 6 312688;24539;63868;29328;80841;29184 USP18_10138;LPL_32544;HSPD1_8849;GPX4_32827;FABP7_8592;CD36_8243 57.33266666666666 47.025000000000006 29.851730230836996 38.859966666666665 35.881550000000004 20.680363593386534 95.18979999999999 86.4061 45.53186126452557 108.883;74.2041;42.2579;45.9204;24.601;48.1296 73.1414;49.8682;23.9469;34.2198;14.4402;37.5433 138.144;155.425;102.383;70.4292;35.6155;69.1421 14 79426;85253;25493;288001;65164;24471;25675;25661;361969;24890;25423;113936;114851;25373 ZFP36_10204;PLG_9501;NFKBIA_9307;KNG1L1_34113;HTRA1_8856;HSPB1_8847;HMGCR_8810;FN1_8655;FGA_8632;ESR1_33192;CTSC_32456;CPB2_8369;CDKN1A_8271;AHSG_8003 30.868631785714285 25.098550000000003 28.066638175431446 21.142199357142857 19.9877 18.310373484146318 49.670415 33.47545 46.97010075824288 0.348134;70.7857;0.520151;24.3655;33.1323;89.1011;1.63089;59.5777;28.5803;23.3972;56.2386;25.8316;6.24967;12.402 0.118102;46.2356;0.160202;19.538;25.6145;60.3265;0.663137;31.0499;22.529;18.3088;38.2681;20.4374;2.44025;10.3013 1.15962;150.579;2.88499;32.1467;46.6629;106.138;7.6286;105.243;38.8511;31.9156;102.888;34.8042;19.0606;15.4235 0 Exp 2,7(0.35);Exp 3,1(0.05);Exp 4,3(0.15);Hill,2(0.1);Linear,4(0.2);Poly 2,1(0.05);Power,2(0.1) 1.8688672535201727 38.37400829792023 1.522104263305664 3.431420087814331 0.49521555900100267 1.7422861456871033 25.45466482033749 52.16101967966251 17.56882163642277 35.34623746357724 41.35547500659253 85.29698599340747 DOWN 0.3 0.7 0.0 GO:0051046 6 regulation of secretion 220 238 28 27 20 23 17 17 145 221 2164 0.751 0.34163 0.57727 7.14 170698;293615;81819;25591;100359982;24539;63868;25675;113965;24957;25661;361969;29496;65210;113936;29184;25303 slco1a2;sirt3;pax8;parp1;mpc2;lpl;hspd1;hmgcr;hadh;glul;fn1;fga;erbb3;cyp2j4;cpb2;cd36;abcc2 SLCO1A2_9886;SIRT3_9828;PAX8_9432;PARP1_9425;MPC2_33219;LPL_32544;HSPD1_8849;HMGCR_8810;HADH_8776;GLUL_32832;FN1_8655;FGA_8632;ERBB3_8571;CYP2J4_32580;CPB2_8369;CD36_8243;ABCC2_32541 41.31480411764706 42.2579 1.63089 25.782137936142217 42.549204111419506 20.736182064980774 29.640372176470585 25.7336 0.56209 18.86267009695359 29.952362390682 14.096296560744998 66.91066294117647 69.127 7.6286 43.34617888815833 71.33479452745837 42.25833039240115 10.5 47.48795 104.197;2.38018;56.8931;26.9741;46.8463;74.2041;42.2579;1.63089;33.3125;26.4669;59.5777;28.5803;60.9984;17.8395;25.8316;48.1296;46.2316 80.3101;0.56209;45.1162;21.799;35.8494;49.8682;23.9469;0.663137;25.7336;21.0456;31.0499;22.529;41.6036;14.6501;20.4374;37.5433;31.1788 128.412;8.82917;81.5688;35.2797;69.127;155.425;102.383;7.6286;46.9856;35.4303;105.243;38.8511;113.972;22.6149;34.8042;69.1421;81.7848 10 7 10 293615;81819;25591;100359982;24539;63868;113965;29496;65210;29184 SIRT3_9828;PAX8_9432;PARP1_9425;MPC2_33219;LPL_32544;HSPD1_8849;HADH_8776;ERBB3_8571;CYP2J4_32580;CD36_8243 40.983568 44.552099999999996 21.409633613752693 29.667238999999995 30.7915 15.173831742718168 70.532727 69.13454999999999 44.88813671120394 2.38018;56.8931;26.9741;46.8463;74.2041;42.2579;33.3125;60.9984;17.8395;48.1296 0.56209;45.1162;21.799;35.8494;49.8682;23.9469;25.7336;41.6036;14.6501;37.5433 8.82917;81.5688;35.2797;69.127;155.425;102.383;46.9856;113.972;22.6149;69.1421 7 170698;25675;24957;25661;361969;113936;25303 SLCO1A2_9886;HMGCR_8810;GLUL_32832;FN1_8655;FGA_8632;CPB2_8369;ABCC2_32541 41.78799857142857 28.5803 32.93296706205422 29.601990999999998 22.529 24.56481600824034 61.736285714285714 38.8511 43.987012273261925 104.197;1.63089;26.4669;59.5777;28.5803;25.8316;46.2316 80.3101;0.663137;21.0456;31.0499;22.529;20.4374;31.1788 128.412;7.6286;35.4303;105.243;38.8511;34.8042;81.7848 0 Exp 2,7(0.42);Exp 3,1(0.06);Exp 4,1(0.06);Hill,1(0.06);Linear,5(0.3);Poly 2,1(0.06);Power,1(0.06) 1.9080901609823127 33.44712519645691 1.5209722518920898 3.8079800605773926 0.5721409805120333 1.8086696863174438 29.058753716981265 53.57085451831286 20.673627992105775 38.607116360835406 46.30519746560717 87.5161284167458 CONFLICT 0.5882352941176471 0.4117647058823529 0.0 GO:0071247 6 cellular response to chromate 2 2 1 1 1 1 1 1 161 1 2384 0.99598 0.12319 0.12319 50.0 24567 mt1 MT1A_9255 12.9315 12.9315 12.9315 12.931500000000002 8.91033 8.91033 8.91033 8.91033 23.4636 23.4636 23.4636 23.4636 0.0 12.9315 0.0 12.9315 12.9315 8.91033 23.4636 0 1 0 1 24567 MT1A_9255 12.9315 12.9315 8.91033 8.91033 23.4636 23.4636 12.9315 8.91033 23.4636 0 Poly 2,1(1) 2.273383855819702 2.273383855819702 2.273383855819702 2.273383855819702 0.0 2.273383855819702 12.9315 12.9315 8.91033 8.91033 23.4636 23.4636 DOWN 0.0 1.0 0.0 GO:0090208 7 positive regulation of triglyceride metabolic process 15 17 3 3 2 3 2 2 160 15 2370 0.91096 0.295 0.295 11.76 25106;29184 rgn;cd36 RGN_9699;CD36_8243 62.78515 62.78515 48.1296 20.726077574037024 58.9406794340827 20.000259591830076 48.15825 48.15825 37.5433 15.0118062539123 45.37371698461103 14.486099501847182 79.4734 79.4734 69.1421 14.610664576945227 76.76327456917949 14.099005627292966 0.0 48.1296 0.5 62.78515 77.4407;48.1296 58.7732;37.5433 89.8047;69.1421 2 0 2 25106;29184 RGN_9699;CD36_8243 62.78515 62.78515 20.726077574037024 48.15825 48.15825 15.0118062539123 79.4734 79.4734 14.610664576945227 77.4407;48.1296 58.7732;37.5433 89.8047;69.1421 0 0 Exp 2,1(0.5);Poly 2,1(0.5) 2.143042579045372 4.390197277069092 1.7198865413665771 2.6703107357025146 0.6720513928187025 2.195098638534546 34.060272 91.510028 27.352948000000005 68.96355199999999 59.224052 99.722748 UP 1.0 0.0 0.0 GO:0005977 6 glycogen metabolic process 15 16 4 4 4 3 3 3 159 13 2372 0.98429 0.076773 0.076773 18.75 29573;192280;24158 slc37a4;ppp1r3b;acadm SLC37A4_9871;PPP1R3B_9545;ACADM_7957 29.190466666666666 36.1411 11.7137 15.24054066965255 33.02553675992513 12.521525086409834 19.37047 22.6911 8.36151 9.780956038838942 21.968695340853124 8.254883959934643 44.20733333333334 53.6244 18.9642 22.09481060369905 49.71234083341543 18.187351917964847 0.0 11.7137 0.5 23.9274 39.7166;36.1411;11.7137 22.6911;27.0588;8.36151 60.0334;53.6244;18.9642 1 2 1 24158 ACADM_7957 11.7137 11.7137 8.36151 8.36151 18.9642 18.9642 11.7137 8.36151 18.9642 2 29573;192280 SLC37A4_9871;PPP1R3B_9545 37.92885 37.92885 2.5282602961326943 24.87495 24.87495 3.088430288188487 56.828900000000004 56.828900000000004 4.531847360624452 39.7166;36.1411 22.6911;27.0588 60.0334;53.6244 0 Exp 2,1(0.34);Poly 2,2(0.67) 1.8198292164911394 5.46654486656189 1.693061113357544 1.893584966659546 0.11203083161288228 1.8798987865447998 11.944171360556766 46.436761972776566 8.302276300167104 30.438663699832897 19.20470142784399 69.20996523882269 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0006073 6 cellular glucan metabolic process 15 16 4 4 4 3 3 3 159 13 2372 0.98429 0.076773 0.076773 18.75 29573;192280;24158 slc37a4;ppp1r3b;acadm SLC37A4_9871;PPP1R3B_9545;ACADM_7957 29.190466666666666 36.1411 11.7137 15.24054066965255 33.02553675992513 12.521525086409834 19.37047 22.6911 8.36151 9.780956038838942 21.968695340853124 8.254883959934643 44.20733333333334 53.6244 18.9642 22.09481060369905 49.71234083341543 18.187351917964847 0.0 11.7137 0.5 23.9274 39.7166;36.1411;11.7137 22.6911;27.0588;8.36151 60.0334;53.6244;18.9642 1 2 1 24158 ACADM_7957 11.7137 11.7137 8.36151 8.36151 18.9642 18.9642 11.7137 8.36151 18.9642 2 29573;192280 SLC37A4_9871;PPP1R3B_9545 37.92885 37.92885 2.5282602961326943 24.87495 24.87495 3.088430288188487 56.828900000000004 56.828900000000004 4.531847360624452 39.7166;36.1411 22.6911;27.0588 60.0334;53.6244 0 Exp 2,1(0.34);Poly 2,2(0.67) 1.8198292164911394 5.46654486656189 1.693061113357544 1.893584966659546 0.11203083161288228 1.8798987865447998 11.944171360556766 46.436761972776566 8.302276300167104 30.438663699832897 19.20470142784399 69.20996523882269 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0044042 6 glucan metabolic process 15 16 4 4 4 3 3 3 159 13 2372 0.98429 0.076773 0.076773 18.75 29573;192280;24158 slc37a4;ppp1r3b;acadm SLC37A4_9871;PPP1R3B_9545;ACADM_7957 29.190466666666666 36.1411 11.7137 15.24054066965255 33.02553675992513 12.521525086409834 19.37047 22.6911 8.36151 9.780956038838942 21.968695340853124 8.254883959934643 44.20733333333334 53.6244 18.9642 22.09481060369905 49.71234083341543 18.187351917964847 0.0 11.7137 0.5 23.9274 39.7166;36.1411;11.7137 22.6911;27.0588;8.36151 60.0334;53.6244;18.9642 1 2 1 24158 ACADM_7957 11.7137 11.7137 8.36151 8.36151 18.9642 18.9642 11.7137 8.36151 18.9642 2 29573;192280 SLC37A4_9871;PPP1R3B_9545 37.92885 37.92885 2.5282602961326943 24.87495 24.87495 3.088430288188487 56.828900000000004 56.828900000000004 4.531847360624452 39.7166;36.1411 22.6911;27.0588 60.0334;53.6244 0 Exp 2,1(0.34);Poly 2,2(0.67) 1.8198292164911394 5.46654486656189 1.693061113357544 1.893584966659546 0.11203083161288228 1.8798987865447998 11.944171360556766 46.436761972776566 8.302276300167104 30.438663699832897 19.20470142784399 69.20996523882269 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0007417 5 central nervous system development 17 18 2 2 2 2 2 2 160 16 2369 0.89794 0.31912 0.31912 11.11 81819;65183 pax8;aldh3a2 PAX8_9432;ALDH3A2_8024 50.0005 50.0005 43.1079 9.747608400012737 50.8732259741149 9.669155509568121 38.4968 38.4968 31.8774 9.361245254772474 39.334933986167215 9.285901978939023 73.9373 73.9373 66.3058 10.792570801250312 74.90358388002464 10.705707609794617 0.0 43.1079 0.5 50.0005 56.8931;43.1079 45.1162;31.8774 81.5688;66.3058 2 0 2 81819;65183 PAX8_9432;ALDH3A2_8024 50.0005 50.0005 9.747608400012737 38.4968 38.4968 9.361245254772474 73.9373 73.9373 10.792570801250312 56.8931;43.1079 45.1162;31.8774 81.5688;66.3058 0 0 Exp 2,1(0.5);Linear,1(0.5) 1.632204267403643 3.2726259231567383 1.520427942276001 1.7521979808807373 0.16388616597327696 1.6363129615783691 36.491004000000004 63.509996 25.522776000000007 51.47082399999999 58.979560000000006 88.89503999999998 UP 1.0 0.0 0.0 GO:0045860 8 positive regulation of protein kinase activity 136 148 10 10 8 9 7 7 155 141 2244 0.26169 0.84498 0.48956 4.73 24825;29455;299626;25112;29496;24330;114851 tf;gdf15;gadd45b;gadd45a;erbb3;egr1;cdkn1a TF_10003;GDF15_33113;GADD45B_8679;GADD45A_8678;ERBB3_8571;EGR1_8533;CDKN1A_8271 61.083855285714286 60.9984 0.750017 45.90426669242665 56.47592355572553 46.00614057357929 42.84642414285714 41.6036 0.186019 35.94229818902694 42.652738130194976 38.84856921668997 78.54164 109.434 4.70178 50.116326990498145 74.65324373499946 51.39016751102192 45.1539;105.149;106.367;102.919;60.9984;0.750017;6.24967 28.132;85.3487;52.7132;89.5012;41.6036;0.186019;2.44025 61.5341;125.652;109.434;115.437;113.972;4.70178;19.0606 3 4 3 24825;299626;29496 TF_10003;GADD45B_8679;ERBB3_8571 70.83976666666666 60.9984 31.771060358498172 40.81626666666667 41.6036 12.309499124388989 94.98003333333332 109.434 29.053764014380924 45.1539;106.367;60.9984 28.132;52.7132;41.6036 61.5341;109.434;113.972 4 29455;25112;24330;114851 GDF15_33113;GADD45A_8678;EGR1_8533;CDKN1A_8271 53.766921749999995 54.584334999999996 58.09396458820457 44.36904224999999 43.894475 49.75408584740125 66.212845 67.2488 63.14791078241702 105.149;102.919;0.750017;6.24967 85.3487;89.5012;0.186019;2.44025 125.652;115.437;4.70178;19.0606 0 Exp 4,1(0.15);Hill,1(0.15);Linear,1(0.15);Poly 2,3(0.43);Power,1(0.15) 1.8518221958524967 13.923458695411682 1.522104263305664 4.21828556060791 0.9884164139095439 1.6013026237487793 27.077498625929273 95.0902119454993 16.219997027095236 69.47285125861904 41.41494540456139 115.66833459543861 CONFLICT 0.42857142857142855 0.5714285714285714 0.0 GO:0042476 5 odontogenesis 21 21 2 2 2 2 2 2 160 19 2366 0.85485 0.39001 0.39001 9.52 65164;29496 htra1;erbb3 HTRA1_8856;ERBB3_8571 47.065349999999995 47.065349999999995 33.1323 19.70430827522245 45.68977463799912 19.608042978632835 33.609049999999996 33.609049999999996 25.6145 11.306001035069862 32.81976796840719 11.250765625245682 80.31745 80.31745 46.6629 47.59472104556343 76.99482000877576 47.36219728103664 0.5 47.065349999999995 33.1323;60.9984 25.6145;41.6036 46.6629;113.972 1 1 1 29496 ERBB3_8571 60.9984 60.9984 41.6036 41.6036 113.972 113.972 60.9984 41.6036 113.972 1 65164 HTRA1_8856 33.1323 33.1323 25.6145 25.6145 46.6629 46.6629 33.1323 25.6145 46.6629 0 Linear,2(1) 1.5806734949338102 3.1616127490997314 1.5603101253509521 1.6013026237487793 0.028986073594882263 1.5808063745498657 19.756572000000006 74.37412799999998 17.939731999999996 49.278368 14.35453200000002 146.280368 CONFLICT 0.5 0.5 0.0 GO:0006468 7 protein phosphorylation 190 202 11 11 7 8 5 5 157 197 2188 0.0079659 0.99746 0.015364 2.48 79426;246273;24825;25513;29496 zfp36;trib3;tf;pik3r1;erbb3 ZFP36_10204;TRIB3_10079;TF_10003;PIK3R1_32562;ERBB3_8571 46.6593668 45.1539 0.348134 41.542294832878596 52.24482434580178 35.70838529481797 33.0814804 28.132 0.118102 32.492348178973174 36.44060955386375 28.44887472540008 72.338304 61.5341 1.15962 56.8225835082591 81.25289635275477 49.59140948380702 0.348134;108.064;45.1539;18.7324;60.9984 0.118102;83.8836;28.132;11.6701;41.6036 1.15962;143.428;61.5341;41.5978;113.972 2 3 2 24825;29496 TF_10003;ERBB3_8571 53.07615 53.07615 11.20375339451025 34.8678 34.8678 9.525859713432697 87.75305 87.75305 37.07919468118202 45.1539;60.9984 28.132;41.6036 61.5341;113.972 3 79426;246273;25513 ZFP36_10204;TRIB3_10079;PIK3R1_32562 42.38151133333333 18.7324 57.62063256486156 31.890600666666668 11.6701 45.3962129390217 62.06180666666666 41.5978 73.30862611996035 0.348134;108.064;18.7324 0.118102;83.8836;11.6701 1.15962;143.428;41.5978 0 Hill,1(0.2);Linear,1(0.2);Poly 2,3(0.6) 1.7803442474059592 8.9246666431427 1.6013026237487793 1.9381765127182007 0.1419142700360061 1.8344712257385254 10.245939886439317 83.07279371356067 4.600681483504001 61.562279316496 22.531113522402684 122.14549447759734 DOWN 0.4 0.6 0.0 GO:0009611 4 response to wounding 115 120 11 11 9 9 7 7 155 113 2272 0.50025 0.65208 1.0 5.83 79426;29482;58954;24516;25661;29496;24330 zfp36;slc1a2;klf6;jun;fn1;erbb3;egr1 ZFP36_10204;SLC1A2_33059;KLF6_8969;JUN_8938;FN1_8655;ERBB3_8571;EGR1_8533 24.339678714285714 16.4324 0.348134 25.594928244347134 31.529989719790454 27.78880437441633 14.897663 10.5224 0.118102 15.66247141678787 18.694047456457753 16.465459372278612 47.89011428571428 39.929 1.15962 45.30055104985179 59.67726160937542 48.40244125692591 5.0 59.5777 0.348134;13.3235;18.9476;16.4324;59.5777;60.9984;0.750017 0.118102;9.10952;11.6941;10.5224;31.0499;41.6036;0.186019 1.15962;24.6773;45.5481;39.929;105.243;113.972;4.70178 1 6 1 29496 ERBB3_8571 60.9984 60.9984 41.6036 41.6036 113.972 113.972 60.9984 41.6036 113.972 6 79426;29482;58954;24516;25661;24330 ZFP36_10204;SLC1A2_33059;KLF6_8969;JUN_8938;FN1_8655;EGR1_8533 18.229891833333333 14.87795 21.738276336048564 10.446673500000001 9.81596 11.31196843230701 36.876466666666666 32.30315 37.995319000387745 0.348134;13.3235;18.9476;16.4324;59.5777;0.750017 0.118102;9.10952;11.6941;10.5224;31.0499;0.186019 1.15962;24.6773;45.5481;39.929;105.243;4.70178 0 Hill,2(0.29);Linear,1(0.15);Poly 2,3(0.43);Power,1(0.15) 1.9757927247827054 14.709864377975464 1.5740432739257812 4.21828556060791 0.9474864935504692 1.7792335748672485 5.3786905257417565 43.300666902829676 3.2947418000661113 26.50058419993389 14.330996432728021 81.44923213870055 DOWN 0.14285714285714285 0.8571428571428571 0.0 GO:0006810 4 transport 570 605 55 53 40 49 35 35 127 570 1815 0.28825 0.77431 0.56731 5.79 79426;24856;171139;24825;170698;29573;25351;65192;361074;29482;29500;297784;308821;298199;25513;25493;100359982;81678;192235;63868;24471;85255;24384;24360;304929;25428;83842;170945;81718;114851;29184;65054;312382;140668;25303 zfp36;ttr;timm9;tf;slco1a2;slc37a4;slc2a2;slc27a2;slc25a30;slc1a2;slc10a2;rrs1;rab30;plin2;pik3r1;nfkbia;mpc2;itpr2;hyou1;hspd1;hspb1;hacl1;gc;fabp1;f5;cyp7a1;crot;chrna2;cdo1;cdkn1a;cd36;aqp9;abcg2;abcc3;abcc2 ZFP36_10204;TTR_10102;TIMM9_10020;TF_10003;SLCO1A2_9886;SLC37A4_9871;SLC2A2_9863;SLC27A2_9860;SLC25A30_9856;SLC1A2_33059;SLC10A2_9833;RRS1_9755;RAB30_9639;PLIN2_9502;PIK3R1_32562;NFKBIA_9307;MPC2_33219;ITPR2_8931;HYOU1_8857;HSPD1_8849;HSPB1_8847;HACL1_8775;GC_32893;FABP1_33091;F5_33079;CYP7A1_8430;CROT_8384;CHRNA2_32401;CDO1_8275;CDKN1A_8271;CD36_8243;AQP9_32709;ABCG2_32656;ABCC3_7941;ABCC2_32541 171139(0.04986) 33.65769614285715 33.8478 0.348134 23.418833464049595 34.88861557422366 21.158057755887878 23.762601342857145 23.9469 0.118102 17.427092173633802 24.45860452375583 15.350149306182587 52.91985742857142 46.9257 1.15962 33.039713571519236 54.57169716040657 30.824278827807415 29.5 51.20215 0.348134;46.6406;38.5191;45.1539;104.197;39.7166;29.7555;7.62189;53.013;13.3235;56.585;60.39;26.4203;25.6517;18.7324;0.520151;46.8463;31.8111;40.1982;42.2579;89.1011;17.6275;42.356;33.8478;10.6089;5.72128;7.4229;49.3913;22.9638;6.24967;48.1296;27.7316;5.21654;37.7175;46.2316 0.118102;28.5876;29.55;28.132;80.3101;22.6911;23.3399;5.49916;37.4804;9.10952;35.2796;43.109;21.0125;20.9252;11.6701;0.160202;35.8494;24.7342;29.3844;23.9469;60.3265;11.195;26.3722;26.4736;2.59129;0.985273;5.75707;41.8524;18.5144;2.44025;37.5433;21.9372;2.73368;30.9007;31.1788 1.15962;63.7146;55.4685;61.5341;128.412;60.0334;40.808;13.3925;90.2594;24.6773;116.8;104.942;35.3561;33.0375;41.5978;2.88499;69.127;44.3296;62.3571;102.383;106.138;37.6534;78.7583;46.9257;37.5078;22.3625;10.316;62.472;30.0179;19.0606;69.1421;37.4625;11.386;48.9329;81.7848 17 18 17 24856;171139;24825;65192;361074;297784;308821;298199;100359982;63868;85255;24360;83842;170945;29184;312382;140668 TTR_10102;TIMM9_10020;TF_10003;SLC27A2_9860;SLC25A30_9856;RRS1_9755;RAB30_9639;PLIN2_9502;MPC2_33219;HSPD1_8849;HACL1_8775;FABP1_33091;CROT_8384;CHRNA2_32401;CD36_8243;ABCG2_32656;ABCC3_7941 34.815754705882355 38.5191 17.06727548779539 25.326347647058824 28.132 12.727575456313119 53.884870588235295 55.4685 28.979373483431363 46.6406;38.5191;45.1539;7.62189;53.013;60.39;26.4203;25.6517;46.8463;42.2579;17.6275;33.8478;7.4229;49.3913;48.1296;5.21654;37.7175 28.5876;29.55;28.132;5.49916;37.4804;43.109;21.0125;20.9252;35.8494;23.9469;11.195;26.4736;5.75707;41.8524;37.5433;2.73368;30.9007 63.7146;55.4685;61.5341;13.3925;90.2594;104.942;35.3561;33.0375;69.127;102.383;37.6534;46.9257;10.316;62.472;69.1421;11.386;48.9329 18 79426;170698;29573;25351;29482;29500;25513;25493;81678;192235;24471;24384;304929;25428;81718;114851;65054;25303 ZFP36_10204;SLCO1A2_9886;SLC37A4_9871;SLC2A2_9863;SLC1A2_33059;SLC10A2_9833;PIK3R1_32562;NFKBIA_9307;ITPR2_8931;HYOU1_8857;HSPB1_8847;GC_32893;F5_33079;CYP7A1_8430;CDO1_8275;CDKN1A_8271;AQP9_32709;ABCC2_32541 32.56397416666667 28.74355 28.637715560644075 22.285729833333335 22.314149999999998 21.217682346483773 52.008456111111116 41.2029 37.29652442334495 0.348134;104.197;39.7166;29.7555;13.3235;56.585;18.7324;0.520151;31.8111;40.1982;89.1011;42.356;10.6089;5.72128;22.9638;6.24967;27.7316;46.2316 0.118102;80.3101;22.6911;23.3399;9.10952;35.2796;11.6701;0.160202;24.7342;29.3844;60.3265;26.3722;2.59129;0.985273;18.5144;2.44025;21.9372;31.1788 1.15962;128.412;60.0334;40.808;24.6773;116.8;41.5978;2.88499;44.3296;62.3571;106.138;78.7583;37.5078;22.3625;30.0179;19.0606;37.4625;81.7848 0 Exp 2,11(0.32);Exp 3,2(0.06);Exp 4,3(0.09);Hill,4(0.12);Linear,6(0.18);Poly 2,9(0.26) 2.05145887178508 76.10058617591858 1.5074360370635986 5.963563919067383 0.9229504717411646 1.8589661121368408 25.899025659632475 41.41636662608182 17.988997552404825 29.53620513330946 41.973784864578874 63.86592999256396 CONFLICT 0.4857142857142857 0.5142857142857142 0.0 GO:0051093 5 negative regulation of developmental process 252 270 21 21 18 17 16 16 146 254 2131 0.44127 0.66137 0.89498 5.93 79426;246273;24794;25106;83516;25513;81819;25493;29455;25112;294515;25423;113936;114851;29184;25373 zfp36;trib3;serpina3c;rgn;ppargc1a;pik3r1;pax8;nfkbia;gdf15;gadd45a;foxo3;ctsc;cpb2;cdkn1a;cd36;ahsg ZFP36_10204;TRIB3_10079;SERPINA3C_32925;RGN_9699;PPARGC1A_33189;PIK3R1_32562;PAX8_9432;NFKBIA_9307;GDF15_33113;GADD45A_8678;FOXO3_8662;CTSC_32456;CPB2_8369;CDKN1A_8271;CD36_8243;AHSG_8003 44.01828468749999 36.0877 0.348134 37.5127187193152 53.94848574863738 36.7261546911594 33.680490875000004 24.8229 0.118102 31.06980279720742 41.87756555709358 31.340764882795714 62.38534437500001 55.36995 1.15962 45.07180002211063 75.11807404654496 41.717364170962895 12.5 90.17985 0.348134;108.064;29.766;77.4407;42.4094;18.7324;56.8931;0.520151;105.149;102.919;13.1992;56.2386;25.8316;6.24967;48.1296;12.402 0.118102;83.8836;23.347;58.7732;26.2988;11.6701;45.1162;0.160202;85.3487;89.5012;5.6804;38.2681;20.4374;2.44025;37.5433;10.3013 1.15962;143.428;40.8256;89.8047;81.7305;41.5978;81.5688;2.88499;125.652;115.437;32.7581;102.888;34.8042;19.0606;69.1421;15.4235 3 13 3 25106;81819;29184 RGN_9699;PAX8_9432;CD36_8243 60.821133333333336 56.8931 15.045172986819873 47.14423333333334 45.1162 10.759268232706786 80.17186666666666 81.5688 10.401890536980938 77.4407;56.8931;48.1296 58.7732;45.1162;37.5433 89.8047;81.5688;69.1421 13 79426;246273;24794;83516;25513;25493;29455;25112;294515;25423;113936;114851;25373 ZFP36_10204;TRIB3_10079;SERPINA3C_32925;PPARGC1A_33189;PIK3R1_32562;NFKBIA_9307;GDF15_33113;GADD45A_8678;FOXO3_8662;CTSC_32456;CPB2_8369;CDKN1A_8271;AHSG_8003 40.14070423076923 25.8316 40.4277917659853 30.573473384615383 20.4374 33.63920412404314 58.280762307692314 40.8256 49.23371884694474 0.348134;108.064;29.766;42.4094;18.7324;0.520151;105.149;102.919;13.1992;56.2386;25.8316;6.24967;12.402 0.118102;83.8836;23.347;26.2988;11.6701;0.160202;85.3487;89.5012;5.6804;38.2681;20.4374;2.44025;10.3013 1.15962;143.428;40.8256;81.7305;41.5978;2.88499;125.652;115.437;32.7581;102.888;34.8042;19.0606;15.4235 0 Exp 2,6(0.38);Exp 4,3(0.19);Hill,1(0.07);Linear,1(0.07);Poly 2,5(0.32) 1.8372692775169743 30.136898279190063 1.522104263305664 3.431420087814331 0.4965906728661365 1.7360422611236572 25.637052515035563 62.39951685996445 18.45628750436836 48.90469424563163 40.30016236416577 84.47052638583419 DOWN 0.1875 0.8125 0.0 GO:0070482 4 response to oxygen levels 182 189 22 22 20 19 17 17 145 172 2213 0.94945 0.087012 0.12224 8.99 24522;24825;24648;83516;24651;81678;192235;63868;24464;294515;24360;116636;24330;140942;114851;192272;170465 zfp354a;tf;serpina1;ppargc1a;pklr;itpr2;hyou1;hspd1;hp;foxo3;fabp1;eif4ebp1;egr1;ddit4;cdkn1a;acot2;acaa2 ZFP354A_10203;TF_10003;SERPINA1_9807;PPARGC1A_33189;PKLR_9489;ITPR2_8931;HYOU1_8857;HSPD1_8849;HP_8823;FOXO3_8662;FABP1_33091;EIF4EBP1_8550;EGR1_8533;DDIT4_8450;CDKN1A_8271;ACOT2_7969;ACAA2_7955 33.35954494117647 31.8111 0.750017 26.426918691153336 32.39569211874251 25.789539293104678 21.40372817647059 23.9469 0.186019 15.474568853329293 20.683025522772976 15.16109829871432 61.550408823529416 44.3296 2.99857 60.87382127208499 56.63946831293855 50.35233060441934 8.5 32.82945 0.834827;45.1539;15.797;42.4094;23.0963;31.8111;40.1982;42.2579;64.9285;13.1992;33.8478;83.9001;0.750017;87.5421;6.24967;8.54905;26.5872 0.27095;28.132;13.013;26.2988;17.4625;24.7342;29.3844;23.9469;41.6103;5.6804;26.4736;42.4185;0.186019;53.2453;2.44025;7.19676;21.3695 2.99857;61.5341;19.9134;81.7305;32.9443;44.3296;62.3571;102.383;136.455;32.7581;46.9257;107.32;4.70178;245.492;19.0606;10.4125;35.0407 6 11 6 24825;63868;24360;116636;192272;170465 TF_10003;HSPD1_8849;FABP1_33091;EIF4EBP1_8550;ACOT2_7969;ACAA2_7955 40.049325 38.05285 25.162591299302818 24.922876666666667 25.210250000000002 11.371844876855578 60.602666666666664 54.2299 38.17983615044291 45.1539;42.2579;33.8478;83.9001;8.54905;26.5872 28.132;23.9469;26.4736;42.4185;7.19676;21.3695 61.5341;102.383;46.9257;107.32;10.4125;35.0407 11 24522;24648;83516;24651;81678;192235;24464;294515;24330;140942;114851 ZFP354A_10203;SERPINA1_9807;PPARGC1A_33189;PKLR_9489;ITPR2_8931;HYOU1_8857;HP_8823;FOXO3_8662;EGR1_8533;DDIT4_8450;CDKN1A_8271 29.710573999999998 23.0963 27.55603142331073 19.484192636363638 17.4625 17.521315588343146 62.06735909090909 32.9443 72.10625875285369 0.834827;15.797;42.4094;23.0963;31.8111;40.1982;64.9285;13.1992;0.750017;87.5421;6.24967 0.27095;13.013;26.2988;17.4625;24.7342;29.3844;41.6103;5.6804;0.186019;53.2453;2.44025 2.99857;19.9134;81.7305;32.9443;44.3296;62.3571;136.455;32.7581;4.70178;245.492;19.0606 0 Exp 2,7(0.42);Exp 3,2(0.12);Exp 4,2(0.12);Hill,2(0.12);Linear,3(0.18);Poly 2,1(0.06) 2.3122049226747126 47.40243756771088 1.522104263305664 11.836054801940918 2.5008042044016006 1.8344712257385254 20.796985225791747 45.9221046565612 14.047585087611013 28.759871265330176 32.6128310540021 90.48798659305672 DOWN 0.35294117647058826 0.6470588235294118 0.0 GO:1900182 7 positive regulation of protein localization to nucleus 32 34 3 3 2 3 2 2 160 32 2353 0.63122 0.64759 1.0 5.88 25513;25591 pik3r1;parp1 PIK3R1_32562;PARP1_9425 22.85325 22.85325 18.7324 5.827761958505164 24.53378238186288 5.321130638503475 16.73455 16.73455 11.6701 7.162213875960422 18.799893854138215 6.539573161403347 38.43875 38.43875 35.2797 4.467571354214705 37.150451270144764 4.079186998693203 0.5 22.85325 18.7324;26.9741 11.6701;21.799 41.5978;35.2797 1 1 1 25591 PARP1_9425 26.9741 26.9741 21.799 21.799 35.2797 35.2797 26.9741 21.799 35.2797 1 25513 PIK3R1_32562 18.7324 18.7324 11.6701 11.6701 41.5978 41.5978 18.7324 11.6701 41.5978 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.7398142156299028 3.4822497367858887 1.6735800504684448 1.8086696863174438 0.09552279757684853 1.7411248683929443 14.776383999999998 30.930115999999998 6.808228 26.660871999999998 32.247012 44.630488 CONFLICT 0.5 0.5 0.0 GO:0000956 8 nuclear-transcribed mRNA catabolic process 15 16 2 2 2 2 2 2 160 14 2371 0.92323 0.27077 0.27077 12.5 79426;308441 zfp36;exosc5 ZFP36_10204;EXOSC5_32543 21.140517 21.140517 0.348134 29.404870032655776 14.444664847457625 27.838417870632753 15.925851 15.925851 0.118102 22.35553302638973 10.835219966101695 21.164612168604105 31.64846 31.64846 1.15962 43.11773102902332 21.83002 40.82076923606414 0.0 0.348134 0.5 21.140517 0.348134;41.9329 0.118102;31.7336 1.15962;62.1373 1 1 1 308441 EXOSC5_32543 41.9329 41.9329 31.7336 31.7336 62.1373 62.1373 41.9329 31.7336 62.1373 1 79426 ZFP36_10204 0.348134 0.348134 0.118102 0.118102 1.15962 1.15962 0.348134 0.118102 1.15962 0 Exp 2,1(0.5);Hill,1(0.5) 1.7598739321134846 3.536150813102722 1.5979743003845215 1.9381765127182007 0.24055929131581028 1.768075406551361 -19.612553679999987 61.89358767999998 -15.057337039999995 46.909039039999996 -28.10966639999999 91.4065864 CONFLICT 0.5 0.5 0.0 GO:0006518 5 peptide metabolic process 59 74 7 7 6 6 5 5 157 69 2316 0.67 0.51274 0.80867 6.76 293656;364070;81869;57298;29328 rgd1307603;iars2;gstm7;gstm3l;gpx4 RGD1307603_9684;IARS2_8858;GSTM7_8761;GSTM3_8760;GPX4_32827 44.15986 42.3152 24.7304 18.09764276302304 48.946365121698605 16.824197580413454 32.60478 31.4035 19.8021 11.867660696489445 35.800680709476964 10.967594897302074 71.8997 64.5991 32.7087 41.19036194894384 81.57130454427758 39.937287514278786 2.5 44.1178 34.7372;24.7304;42.3152;73.0961;45.9204 26.1766;19.8021;31.4035;51.4219;34.2198 50.9085;32.7087;64.5991;140.853;70.4292 4 1 4 364070;81869;57298;29328 IARS2_8858;GSTM7_8761;GSTM3_8760;GPX4_32827 46.515525 44.1178 19.992628161962628 34.211825 32.81165 13.060291076229262 77.14750000000001 67.51415 45.591649722070805 24.7304;42.3152;73.0961;45.9204 19.8021;31.4035;51.4219;34.2198 32.7087;64.5991;140.853;70.4292 1 293656 RGD1307603_9684 34.7372 34.7372 26.1766 26.1766 50.9085 50.9085 34.7372 26.1766 50.9085 0 Exp 2,3(0.6);Linear,2(0.4) 1.8583040473864856 9.403191208839417 1.547789216041565 2.440005302429199 0.33792012488121903 1.7569831609725952 28.29657669535436 60.02314330464563 22.202316747908874 43.00724325209112 35.79475586042162 108.00464413957837 UP 0.8 0.2 0.0 GO:1904635 10 positive regulation of glomerular visceral epithelial cell apoptotic process 1 1 1 1 1 1 1 1 161 0 2385 1.0 0.063604 0.063604 100.0 83516 ppargc1a PPARGC1A_33189 42.4094 42.4094 42.4094 42.4094 26.2988 26.2988 26.2988 26.2988 81.7305 81.7305 81.7305 81.7305 0.0 42.4094 0.0 42.4094 42.4094 26.2988 81.7305 0 1 0 1 83516 PPARGC1A_33189 42.4094 42.4094 26.2988 26.2988 81.7305 81.7305 42.4094 26.2988 81.7305 0 Exp 2,1(1) 1.7576230764389038 1.7576230764389038 1.7576230764389038 1.7576230764389038 0.0 1.7576230764389038 42.4094 42.4094 26.2988 26.2988 81.7305 81.7305 DOWN 0.0 1.0 0.0 GO:0045454 4 cell redox homeostasis 21 21 2 2 2 2 2 2 160 19 2366 0.85485 0.39001 0.39001 9.52 360722;24314 pdia5;nqo1 PDIA5_9451;NQO1_33055 97.17125 97.17125 87.2765 13.993289646291203 99.78017716262976 13.498116655489014 61.01765 61.01765 60.6992 0.45035630893731965 61.101615017301036 0.43441979321704177 155.688 155.688 114.259 58.58945367555496 144.76450588235292 56.516180289572574 0.5 97.17125 107.066;87.2765 61.3361;60.6992 114.259;197.117 1 1 1 24314 NQO1_33055 87.2765 87.2765 60.6992 60.6992 197.117 197.117 87.2765 60.6992 197.117 1 360722 PDIA5_9451 107.066 107.066 61.3361 61.3361 114.259 114.259 107.066 61.3361 114.259 0 Exp 2,1(0.5);Exp 3,1(0.5) 1.621566988810327 3.244408965110779 1.576730489730835 1.6676784753799438 0.0643099373877417 1.6222044825553894 77.77754 116.56496 60.393488 61.64181200000001 74.48716 236.88883999999996 CONFLICT 0.5 0.5 0.0 GO:1901033 7 positive regulation of response to reactive oxygen species 4 7 3 3 3 3 3 3 159 4 2381 0.99953 0.0073103 0.0073103 42.86 293615;25106;294515 sirt3;rgn;foxo3 SIRT3_9828;RGN_9699;FOXO3_8662 31.006693333333335 13.1992 2.38018 40.5752452830557 36.29583450012425 44.056117000766584 21.67189666666667 5.6804 0.56209 32.23242631400922 26.386621072641432 34.5691846778114 43.79732333333333 32.7581 8.82917 41.601171300188575 47.20740532841878 46.402655718858824 0.0 2.38018 0.0 2.38018 2.38018;77.4407;13.1992 0.56209;58.7732;5.6804 8.82917;89.8047;32.7581 2 1 2 293615;25106 SIRT3_9828;RGN_9699 39.91044 39.91044 53.075802691388475 29.667645 29.667645 41.161470621396056 49.316935 49.316935 57.25834637317472 2.38018;77.4407 0.56209;58.7732 8.82917;89.8047 1 294515 FOXO3_8662 13.1992 13.1992 5.6804 5.6804 32.7581 32.7581 13.1992 5.6804 32.7581 0 Exp 4,1(0.34);Hill,1(0.34);Poly 2,1(0.34) 1.7326227388480546 5.229200124740601 1.5209722518920898 1.9883413314819336 0.23454520724502767 1.7198865413665771 -14.908519088416973 76.92190575508366 -14.80252735102821 58.14632068436155 -3.278833666251174 90.87348033291784 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0044057 5 regulation of system process 160 167 16 16 9 14 7 7 155 160 2225 0.15177 0.91889 0.32269 4.19 24825;25513;25591;294515;361969;25423;312382 tf;pik3r1;parp1;foxo3;fga;ctsc;abcg2 TF_10003;PIK3R1_32562;PARP1_9425;FOXO3_8662;FGA_8632;CTSC_32456;ABCG2_32656 27.727862857142856 26.9741 5.21654 17.87262228321082 30.070342717900658 18.356861122085053 18.68746857142857 21.799 2.73368 12.714754925318628 20.92495485830321 12.61154762009417 46.327828571428576 38.8511 11.386 28.97035377057693 47.752585678582584 31.477517530358508 45.1539;18.7324;26.9741;13.1992;28.5803;56.2386;5.21654 28.132;11.6701;21.799;5.6804;22.529;38.2681;2.73368 61.5341;41.5978;35.2797;32.7581;38.8511;102.888;11.386 3 4 3 24825;25591;312382 TF_10003;PARP1_9425;ABCG2_32656 25.781513333333333 26.9741 19.995371418419154 17.554893333333336 21.799 13.220362920666487 36.0666 35.2797 25.083309034296093 45.1539;26.9741;5.21654 28.132;21.799;2.73368 61.5341;35.2797;11.386 4 25513;294515;361969;25423 PIK3R1_32562;FOXO3_8662;FGA_8632;CTSC_32456 29.187624999999997 23.65635 19.12298404091701 19.5369 17.09955 14.302676326944317 54.02375 40.224450000000004 32.7849372904184 18.7324;13.1992;28.5803;56.2386 11.6701;5.6804;22.529;38.2681 41.5978;32.7581;38.8511;102.888 0 Exp 2,2(0.29);Exp 4,2(0.29);Linear,1(0.15);Poly 2,2(0.29) 1.6961262586142616 11.928035378456116 1.5074360370635986 1.9883413314819336 0.17872810507847295 1.6735800504684448 14.487638982512031 40.96808673177368 9.26824630764109 28.10669083521605 24.86629015968607 67.78936698317106 CONFLICT 0.42857142857142855 0.5714285714285714 0.0 GO:0034976 5 response to endoplasmic reticulum stress 55 58 5 5 4 5 4 4 158 54 2331 0.69228 0.50986 0.78448 6.9 246273;25513;24516;192235 trib3;pik3r1;jun;hyou1 TRIB3_10079;PIK3R1_32562;JUN_8938;HYOU1_8857 45.85675 29.4653 16.4324 42.83022249342941 48.68547580900331 44.866351560305816 33.865125 20.52725 10.5224 34.44525454992555 36.14572800230116 36.075229030304854 71.82797500000001 51.977450000000005 39.929 48.81143697894138 75.16363970228677 51.155666916824366 1.5 29.4653 108.064;18.7324;16.4324;40.1982 83.8836;11.6701;10.5224;29.3844 143.428;41.5978;39.929;62.3571 0 4 0 4 246273;25513;24516;192235 TRIB3_10079;PIK3R1_32562;JUN_8938;HYOU1_8857 45.85675 29.4653 42.83022249342941 33.865125 20.52725 34.44525454992555 71.82797500000001 51.977450000000005 48.81143697894138 108.064;18.7324;16.4324;40.1982 83.8836;11.6701;10.5224;29.3844 143.428;41.5978;39.929;62.3571 0 Exp 2,1(0.25);Poly 2,3(0.75) 1.7901047192510893 7.181313753128052 1.6520916223526 1.9785058498382568 0.15873031042170593 1.7753581404685974 3.883131956439186 87.83036804356081 0.1087755410729585 67.62147445892704 23.992766760637437 119.66318323936255 DOWN 0.0 1.0 0.0 GO:0030104 6 water homeostasis 14 14 2 2 2 2 2 2 160 12 2373 0.94527 0.22236 0.22236 14.29 246074;155423 scd;anxa7 SCD1_9787;ANXA7_8051 105.05 105.05 104.64 0.5798275605743092 104.99309510473842 0.5742156962281054 53.8393 53.8393 43.9254 14.020371836010602 52.46332575333258 13.88467558731622 265.694 265.694 108.689 222.03860036038782 243.90289492550687 219.88959850175908 0.0 104.64 0.5 105.05 105.46;104.64 63.7532;43.9254 422.699;108.689 2 0 2 246074;155423 SCD1_9787;ANXA7_8051 105.05 105.05 0.5798275605743092 53.8393 53.8393 14.020371836010602 265.694 265.694 222.03860036038782 105.46;104.64 63.7532;43.9254 422.699;108.689 0 0 Exp 2,1(0.5);Exp 3,1(0.5) 1.8597103606358774 3.7829989194869995 1.5461770296096802 2.2368218898773193 0.4883596640868832 1.8914994597434998 104.24640000000001 105.85359999999999 34.40805600000001 73.270544 -42.03579999999994 573.4238 UP 1.0 0.0 0.0 GO:0006508 5 proteolysis 170 184 13 13 12 12 11 11 151 173 2212 0.49032 0.63409 1.0 5.98 312688;29676;85253;25591;65164;24464;361969;25423;497840;113936;291394 usp18;psmb3;plg;parp1;htra1;hp;fga;ctsc;cps1;cpb2;cndp2 USP18_10138;PSMB3_9589;PLG_9501;PARP1_9425;HTRA1_8856;HP_8823;FGA_8632;CTSC_32456;CPS1_32421;CPB2_8369;CNDP2_8341 45.879045454545455 33.1323 23.7888 26.672661004532845 44.940287162502095 22.857531851033222 32.699254545454544 25.6145 19.2724 16.25034295295726 32.02386533763765 13.512594671906047 73.31500000000001 46.311 30.901 48.12327545913721 74.8734844918665 47.52561404354642 8.5 67.8571 108.883;23.7888;70.7857;26.9741;33.1323;64.9285;28.5803;56.2386;31.9826;25.8316;33.544 73.1414;19.2724;46.2356;21.799;25.6145;41.6103;22.529;38.2681;24.4836;20.4374;26.3005 138.144;30.901;150.579;35.2797;46.6629;136.455;38.8511;102.888;45.5891;34.8042;46.311 4 7 4 312688;29676;25591;291394 USP18_10138;PSMB3_9589;PARP1_9425;CNDP2_8341 48.297475 30.25905 40.59405677250262 35.128325000000004 24.04975 25.508205397136425 62.658925 40.79535 50.73933044318283 108.883;23.7888;26.9741;33.544 73.1414;19.2724;21.799;26.3005 138.144;30.901;35.2797;46.311 7 85253;65164;24464;361969;25423;497840;113936 PLG_9501;HTRA1_8856;HP_8823;FGA_8632;CTSC_32456;CPS1_32421;CPB2_8369 44.49708571428572 33.1323 18.858738999681172 31.31121428571429 25.6145 10.42147390174547 79.40418571428573 46.6629 49.53332620810047 70.7857;33.1323;64.9285;28.5803;56.2386;31.9826;25.8316 46.2356;25.6145;41.6103;22.529;38.2681;24.4836;20.4374 150.579;46.6629;136.455;38.8511;102.888;45.5891;34.8042 0 Exp 2,7(0.64);Linear,3(0.28);Power,1(0.1) 1.6246857930379397 17.905773758888245 1.5254690647125244 1.8264755010604858 0.10750581097056858 1.5736411809921265 30.116510083976028 61.64158082511487 23.095915548406538 42.302593542502564 44.875961561225694 101.7540384387743 DOWN 0.36363636363636365 0.6363636363636364 0.0 GO:0006355 7 regulation of transcription, DNA-templated 466 499 34 34 26 28 23 23 139 476 1909 0.042318 0.97413 0.081721 4.61 79426;24522;246273;24825;293615;83516;25513;81819;25591;81525;25493;58954;24516;494344;290556;25112;294515;314322;24890;24330;25695;29184;79431 zfp36;zfp354a;trib3;tf;sirt3;ppargc1a;pik3r1;pax8;parp1;nfkbib;nfkbia;klf6;jun;ier2;gnl3;gadd45a;foxo3;fos;esr1;egr1;cebpd;cd36;bhlhe40 ZFP36_10204;ZFP354A_10203;TRIB3_10079;TF_10003;SIRT3_9828;PPARGC1A_33189;PIK3R1_32562;PAX8_9432;PARP1_9425;NFKBIB_9308;NFKBIA_9307;KLF6_8969;JUN_8938;IER2_32643;GNL3_8735;GADD45A_8678;FOXO3_8662;FOS_8657;ESR1_33192;EGR1_8533;CEBPD_8283;CD36_8243;BHLHE40_8141 32.698910652173964 23.3972 1.28141E-12 32.98019628618871 35.49027204024038 32.55206002836877 23.56461292173919 18.3088 1.28141E-12 25.73347673909863 26.739085027866533 26.848229069753643 55.757579130434834 41.2611 1.28142E-12 57.28063909322187 53.49792118975984 45.00332996681684 0.348134;0.834827;108.064;45.1539;2.38018;42.4094;18.7324;56.8931;26.9741;30.5572;0.520151;18.9476;16.4324;49.6814;87.6357;102.919;13.1992;1.28141E-12;23.3972;0.750017;0.306936;48.1296;57.8085 0.118102;0.27095;83.8836;28.132;0.56209;26.2988;11.6701;45.1162;21.799;24.2439;0.160202;11.6941;10.5224;33.4626;54.41;89.5012;5.6804;1.28141E-12;18.3088;0.186019;0.0732342;37.5433;38.3491 1.15962;2.99857;143.428;61.5341;8.82917;81.7305;41.5978;81.5688;35.2797;41.2611;2.88499;45.5481;39.929;89.4404;238.963;115.437;32.7581;1.28142E-12;31.9156;4.70178;1.73689;69.1421;110.58 7 16 7 24825;293615;81819;25591;81525;290556;29184 TF_10003;SIRT3_9828;PAX8_9432;PARP1_9425;NFKBIB_9308;GNL3_8735;CD36_8243 42.53196857142858 45.1539 26.697082140892864 30.25807 28.132 17.565362857215145 76.6539957142857 61.5341 75.51832492083051 45.1539;2.38018;56.8931;26.9741;30.5572;87.6357;48.1296 28.132;0.56209;45.1162;21.799;24.2439;54.41;37.5433 61.5341;8.82917;81.5688;35.2797;41.2611;238.963;69.1421 16 79426;24522;246273;83516;25513;25493;58954;24516;494344;25112;294515;314322;24890;24330;25695;79431 ZFP36_10204;ZFP354A_10203;TRIB3_10079;PPARGC1A_33189;PIK3R1_32562;NFKBIA_9307;KLF6_8969;JUN_8938;IER2_32643;GADD45A_8678;FOXO3_8662;FOS_8657;ESR1_33192;EGR1_8533;CEBPD_8283;BHLHE40_8141 28.39694781250008 17.5824 35.289200540627554 20.63622545000008 11.09625 28.59671833550186 46.61539687500008 36.34355 47.30861627705156 0.348134;0.834827;108.064;42.4094;18.7324;0.520151;18.9476;16.4324;49.6814;102.919;13.1992;1.28141E-12;23.3972;0.750017;0.306936;57.8085 0.118102;0.27095;83.8836;26.2988;11.6701;0.160202;11.6941;10.5224;33.4626;89.5012;5.6804;1.28141E-12;18.3088;0.186019;0.0732342;38.3491 1.15962;2.99857;143.428;81.7305;41.5978;2.88499;45.5481;39.929;89.4404;115.437;32.7581;1.28142E-12;31.9156;4.70178;1.73689;110.58 0 Exp 2,9(0.4);Exp 4,2(0.09);Hill,6(0.27);Poly 2,6(0.27) 1.9560338933732593 47.21514582633972 1.5209722518920898 4.591650485992432 0.7913492383032212 1.8086696863174438 19.22029189613415 46.17752940821381 13.047643306886334 34.08158253659204 32.347654891652496 79.16750336921717 DOWN 0.30434782608695654 0.6956521739130435 0.0 GO:0051173 6 positive regulation of nitrogen compound metabolic process 649 698 49 49 39 41 33 33 129 665 1720 0.021455 0.98672 0.044781 4.73 79426;246273;24825;293615;25106;83516;303612;25513;81819;25591;25493;58954;24516;494344;63868;24471;25675;290556;29455;299626;25112;294515;314322;25661;361969;24890;29496;24330;25423;25695;114851;29184;25698 zfp36;trib3;tf;sirt3;rgn;ppargc1a;polg2;pik3r1;pax8;parp1;nfkbia;klf6;jun;ier2;hspd1;hspb1;hmgcr;gnl3;gdf15;gadd45b;gadd45a;foxo3;fos;fn1;fga;esr1;erbb3;egr1;ctsc;cebpd;cdkn1a;cd36;ass1 ZFP36_10204;TRIB3_10079;TF_10003;SIRT3_9828;RGN_9699;PPARGC1A_33189;POLG2_9521;PIK3R1_32562;PAX8_9432;PARP1_9425;NFKBIA_9307;KLF6_8969;JUN_8938;IER2_32643;HSPD1_8849;HSPB1_8847;HMGCR_8810;GNL3_8735;GDF15_33113;GADD45B_8679;GADD45A_8678;FOXO3_8662;FOS_8657;FN1_8655;FGA_8632;ESR1_33192;ERBB3_8571;EGR1_8533;CTSC_32456;CEBPD_8283;CDKN1A_8271;CD36_8243;ASS1_33159 42.0316720606061 42.2579 1.28141E-12 35.405982000506235 46.11488546464493 32.94798454110789 29.052194975757615 23.9469 1.28141E-12 26.190370013398766 32.84943959424376 26.004148881191032 67.20953787878791 61.5341 1.28142E-12 54.13084068386303 70.3872238941343 44.379314665848284 0.348134;108.064;45.1539;2.38018;77.4407;42.4094;63.7758;18.7324;56.8931;26.9741;0.520151;18.9476;16.4324;49.6814;42.2579;89.1011;1.63089;87.6357;105.149;106.367;102.919;13.1992;1.28141E-12;59.5777;28.5803;23.3972;60.9984;0.750017;56.2386;0.306936;6.24967;48.1296;26.8037 0.118102;83.8836;28.132;0.56209;58.7732;26.2988;40.9553;11.6701;45.1162;21.799;0.160202;11.6941;10.5224;33.4626;23.9469;60.3265;0.663137;54.41;85.3487;52.7132;89.5012;5.6804;1.28141E-12;31.0499;22.529;18.3088;41.6036;0.186019;38.2681;0.0732342;2.44025;37.5433;20.9825 1.15962;143.428;61.5341;8.82917;89.8047;81.7305;132.567;41.5978;81.5688;35.2797;2.88499;45.5481;39.929;89.4404;102.383;106.138;7.6286;238.963;125.652;109.434;115.437;32.7581;1.28142E-12;105.243;38.8511;31.9156;113.972;4.70178;102.888;1.73689;19.0606;69.1421;36.7081 10 23 10 24825;293615;25106;81819;25591;63868;290556;299626;29496;29184 TF_10003;SIRT3_9828;RGN_9699;PAX8_9432;PARP1_9425;HSPD1_8849;GNL3_8735;GADD45B_8679;ERBB3_8571;CD36_8243 55.42305799999999 52.51135 30.010781749340186 36.459948999999995 39.57345 18.001067813148367 91.09105699999999 85.68674999999999 61.62903784378525 45.1539;2.38018;77.4407;56.8931;26.9741;42.2579;87.6357;106.367;60.9984;48.1296 28.132;0.56209;58.7732;45.1162;21.799;23.9469;54.41;52.7132;41.6036;37.5433 61.5341;8.82917;89.8047;81.5688;35.2797;102.383;238.963;109.434;113.972;69.1421 23 79426;246273;83516;303612;25513;25493;58954;24516;494344;24471;25675;29455;25112;294515;314322;25661;361969;24890;24330;25423;25695;114851;25698 ZFP36_10204;TRIB3_10079;PPARGC1A_33189;POLG2_9521;PIK3R1_32562;NFKBIA_9307;KLF6_8969;JUN_8938;IER2_32643;HSPB1_8847;HMGCR_8810;GDF15_33113;GADD45A_8678;FOXO3_8662;FOS_8657;FN1_8655;FGA_8632;ESR1_33192;EGR1_8533;CTSC_32456;CEBPD_8283;CDKN1A_8271;ASS1_33159 36.20933034782614 23.3972 36.578599276912065 25.8314323565218 18.3088 28.7988754948893 56.82626869565223 39.929 48.33525745901053 0.348134;108.064;42.4094;63.7758;18.7324;0.520151;18.9476;16.4324;49.6814;89.1011;1.63089;105.149;102.919;13.1992;1.28141E-12;59.5777;28.5803;23.3972;0.750017;56.2386;0.306936;6.24967;26.8037 0.118102;83.8836;26.2988;40.9553;11.6701;0.160202;11.6941;10.5224;33.4626;60.3265;0.663137;85.3487;89.5012;5.6804;1.28141E-12;31.0499;22.529;18.3088;0.186019;38.2681;0.0732342;2.44025;20.9825 1.15962;143.428;81.7305;132.567;41.5978;2.88499;45.5481;39.929;89.4404;106.138;7.6286;125.652;115.437;32.7581;1.28142E-12;105.243;38.8511;31.9156;4.70178;102.888;1.73689;19.0606;36.7081 0 Exp 2,10(0.31);Exp 3,1(0.04);Exp 4,4(0.13);Hill,5(0.16);Linear,2(0.07);Poly 2,9(0.28);Power,2(0.07) 1.8212181513447334 61.523781299591064 1.5209722518920898 4.21828556060791 0.4965250681151897 1.7576230764389038 29.9514269678289 54.111917153383295 20.116244863489694 37.98814508802553 48.740516950917836 85.67855880665799 DOWN 0.30303030303030304 0.696969696969697 0.0 GO:0046886 7 positive regulation of hormone biosynthetic process 13 14 4 4 4 4 4 4 158 10 2375 0.99878 0.0095446 0.0095446 28.57 83516;29441;24330;25146 ppargc1a;por;egr1;cyp17a1 PPARGC1A_33189;POR_9531;EGR1_8533;CYP17A1_32365 26.323254249999998 27.4254 0.750017 23.46321980902392 21.82274543244284 22.44181137083135 17.66000725 17.394305 0.186019 16.209623594480853 14.325388944548735 15.052505935996592 61.82717 80.4382 4.70178 38.1011223703572 57.52081164187726 40.37741681940577 0.0 0.750017 0.5 6.5957085 42.4094;12.4414;0.750017;49.6922 26.2988;8.48981;0.186019;35.6654 81.7305;79.2355;4.70178;81.6409 1 3 1 25146 CYP17A1_32365 49.6922 49.6922 35.6654 35.6654 81.6409 81.6409 49.6922 35.6654 81.6409 3 83516;29441;24330 PPARGC1A_33189;POR_9531;EGR1_8533 18.533605666666666 12.4414 21.487491137843342 11.658209666666666 8.48981 13.341604109862141 55.22259333333333 79.2355 43.77008900089345 42.4094;12.4414;0.750017 26.2988;8.48981;0.186019 81.7305;79.2355;4.70178 0 Exp 2,1(0.25);Hill,1(0.25);Linear,1(0.25);Poly 2,1(0.25) 2.3015050488979027 9.867241978645325 1.7576230764389038 4.21828556060791 1.1713842601896771 1.9456666707992554 3.3292988371565606 49.31720966284344 1.7745761274087677 33.545438372591235 24.48807007704996 99.16626992295005 DOWN 0.25 0.75 0.0 GO:0006006 6 glucose metabolic process 37 43 7 7 5 5 3 3 159 40 2345 0.70906 0.52221 0.75199 6.98 83516;25513;25685 ppargc1a;pik3r1;igfbp1 PPARGC1A_33189;PIK3R1_32562;IGFBP1_32306 36.722566666666665 42.4094 18.7324 15.92730644469847 35.69544175715696 14.530614947947761 23.552399999999995 26.2988 11.6701 10.774888283875622 22.459156229022707 9.441619891731737 70.8302 81.7305 41.5978 25.58725894131685 69.84312033563674 23.973445494519527 1.5 45.71765 42.4094;18.7324;49.0259 26.2988;11.6701;32.6883 81.7305;41.5978;89.1623 0 3 0 3 83516;25513;25685 PPARGC1A_33189;PIK3R1_32562;IGFBP1_32306 36.722566666666665 42.4094 15.92730644469847 23.552399999999995 26.2988 10.774888283875622 70.8302 81.7305 25.58725894131685 42.4094;18.7324;49.0259 26.2988;11.6701;32.6883 81.7305;41.5978;89.1623 0 Exp 2,2(0.67);Poly 2,1(0.34) 2.2661241835139165 7.387408971786499 1.6735800504684448 3.9562058448791504 1.2942958147969725 1.7576230764389038 18.69912272657451 54.746010606758816 11.359466083679884 35.745333916320114 41.875490758315856 99.78490924168415 DOWN 0.0 1.0 0.0 GO:0050877 4 nervous system process 155 163 10 10 9 9 8 8 154 155 2230 0.27675 0.82869 0.5098 4.91 24516;25675;314322;80841;65030;24330;170945;29184 jun;hmgcr;fos;fabp7;ephx2;egr1;chrna2;cd36 JUN_8938;HMGCR_8810;FOS_8657;FABP7_8592;EPHX2_33282;EGR1_8533;CHRNA2_32401;CD36_8243 22.45806337500016 20.5167 1.28141E-12 21.042324709798585 30.78282184511088 21.603878465849775 16.80214450000016 12.481300000000001 1.28141E-12 17.219372345861945 24.068323091972804 18.00279488977463 34.58753500000016 37.77225 1.28142E-12 27.591986827101277 44.81326864920717 27.546726493735136 16.4324;1.63089;1.28141E-12;24.601;38.7293;0.750017;49.3913;48.1296 10.5224;0.663137;1.28141E-12;14.4402;29.2097;0.186019;41.8524;37.5433 39.929;7.6286;1.28142E-12;35.6155;57.2113;4.70178;62.472;69.1421 4 4 4 80841;65030;170945;29184 FABP7_8592;EPHX2_33282;CHRNA2_32401;CD36_8243 40.2128 43.42945 11.443333663171185 30.761400000000002 33.3765 12.080201308201225 56.110225 59.84165 14.509170274318484 24.601;38.7293;49.3913;48.1296 14.4402;29.2097;41.8524;37.5433 35.6155;57.2113;62.472;69.1421 4 24516;25675;314322;24330 JUN_8938;HMGCR_8810;FOS_8657;EGR1_8533 4.70332675000032 1.1904535 7.847737835056137 2.84288900000032 0.424578 5.127285963153043 13.064845000000322 6.16519 18.183019685338905 16.4324;1.63089;1.28141E-12;0.750017 10.5224;0.663137;1.28141E-12;0.186019 39.929;7.6286;1.28142E-12;4.70178 0 Exp 2,2(0.25);Exp 4,1(0.13);Hill,3(0.38);Linear,1(0.13);Poly 2,1(0.13) 2.5551601175064724 21.759986758232117 1.8966681957244873 4.642963409423828 1.102102591181413 2.2485485076904297 7.876476290656889 37.039650459343434 4.869728245535775 28.734560754464546 15.467263627984028 53.70780637201631 CONFLICT 0.5 0.5 0.0 GO:1901701 5 cellular response to oxygen-containing compound 359 378 53 52 41 46 36 36 126 342 2043 0.99665 0.0061141 0.0085121 9.52 79426;286954;246273;24825;83516;29441;24651;25513;25591;24314;81525;24567;24539;58954;24516;81678;24471;294515;314322;25661;24360;24890;29496;116636;24330;140942;25428;25146;497840;113936;29184;25698;65054;25373;312382;25303 zfp36;ugt2b1;trib3;tf;ppargc1a;por;pklr;pik3r1;parp1;nqo1;nfkbib;mt1;lpl;klf6;jun;itpr2;hspb1;foxo3;fos;fn1;fabp1;esr1;erbb3;eif4ebp1;egr1;ddit4;cyp7a1;cyp17a1;cps1;cpb2;cd36;ass1;aqp9;ahsg;abcg2;abcc2 ZFP36_10204;UGT2B10_33303,UGT2B1_33224;TRIB3_10079;TF_10003;PPARGC1A_33189;POR_9531;PKLR_9489;PIK3R1_32562;PARP1_9425;NQO1_33055;NFKBIB_9308;MT1A_9255;LPL_32544;KLF6_8969;JUN_8938;ITPR2_8931;HSPB1_8847;FOXO3_8662;FOS_8657;FN1_8655;FABP1_33091;ESR1_33192;ERBB3_8571;EIF4EBP1_8550;EGR1_8533;DDIT4_8450;CYP7A1_8430;CYP17A1_32365;CPS1_32421;CPB2_8369;CD36_8243;ASS1_33159;AQP9_32709;AHSG_8003;ABCG2_32656;ABCC2_32541 36.91416169444449 29.1444 1.28141E-12 28.505740670942263 39.983857768576435 26.806686357440142 25.24712400000004 23.09055 1.28141E-12 19.431521854190265 27.214682854712418 17.834866484906208 64.75632083333336 44.93885 1.28142E-12 54.41565941033875 66.56915800862865 45.73000437302448 17.5 29.1444 0.348134;47.47345;108.064;45.1539;42.4094;12.4414;23.0963;18.7324;26.9741;87.2765;30.5572;12.9315;74.2041;18.9476;16.4324;31.8111;89.1011;13.1992;1.28141E-12;59.5777;33.8478;23.3972;60.9984;83.9001;0.750017;87.5421;5.72128;49.6922;31.9826;25.8316;48.1296;26.8037;27.7316;12.402;5.21654;46.2316 0.118102;34.82915;83.8836;28.132;26.2988;8.48981;17.4625;11.6701;21.799;60.6992;24.2439;8.91033;49.8682;11.6941;10.5224;24.7342;60.3265;5.6804;1.28141E-12;31.0499;26.4736;18.3088;41.6036;42.4185;0.186019;53.2453;0.985273;35.6654;24.4836;20.4374;37.5433;20.9825;21.9372;10.3013;2.73368;31.1788 1.15962;76.47475;143.428;61.5341;81.7305;79.2355;32.9443;41.5978;35.2797;197.117;41.2611;23.4636;155.425;45.5481;39.929;44.3296;106.138;32.7581;1.28142E-12;105.243;46.9257;31.9156;113.972;107.32;4.70178;245.492;22.3625;81.6409;45.5891;34.8042;69.1421;36.7081;37.4625;15.4235;11.386;81.7848 13 24 12 286954;24825;25591;24314;81525;24539;24360;29496;116636;25146;29184;312382 UGT2B10_33303,UGT2B1_33224;TF_10003;PARP1_9425;NQO1_33055;NFKBIB_9308;LPL_32544;FABP1_33091;ERBB3_8571;EIF4EBP1_8550;CYP17A1_32365;CD36_8243;ABCG2_32656 49.45199083333333 47.801525 24.215099341382174 33.8341275 35.247275 14.837690215185177 83.12319583333333 72.808425 53.05670259159476 47.47345;45.1539;26.9741;87.2765;30.5572;74.2041;33.8478;60.9984;83.9001;49.6922;48.1296;5.21654 34.82915;28.132;21.799;60.6992;24.2439;49.8682;26.4736;41.6036;42.4185;35.6654;37.5433;2.73368 76.47475;61.5341;35.2797;197.117;41.2611;155.425;46.9257;113.972;107.32;81.6409;69.1421;11.386 24 79426;246273;83516;29441;24651;25513;24567;58954;24516;81678;24471;294515;314322;25661;24890;24330;140942;25428;497840;113936;25698;65054;25373;25303 ZFP36_10204;TRIB3_10079;PPARGC1A_33189;POR_9531;PKLR_9489;PIK3R1_32562;MT1A_9255;KLF6_8969;JUN_8938;ITPR2_8931;HSPB1_8847;FOXO3_8662;FOS_8657;FN1_8655;ESR1_33192;EGR1_8533;DDIT4_8450;CYP7A1_8430;CPS1_32421;CPB2_8369;ASS1_33159;AQP9_32709;AHSG_8003;ABCC2_32541 30.645247125000054 23.24675 28.86292455837394 20.953622250000056 17.88565 20.28755730345633 55.57288333333339 38.695750000000004 53.811236614494646 0.348134;108.064;42.4094;12.4414;23.0963;18.7324;12.9315;18.9476;16.4324;31.8111;89.1011;13.1992;1.28141E-12;59.5777;23.3972;0.750017;87.5421;5.72128;31.9826;25.8316;26.8037;27.7316;12.402;46.2316 0.118102;83.8836;26.2988;8.48981;17.4625;11.6701;8.91033;11.6941;10.5224;24.7342;60.3265;5.6804;1.28141E-12;31.0499;18.3088;0.186019;53.2453;0.985273;24.4836;20.4374;20.9825;21.9372;10.3013;31.1788 1.15962;143.428;81.7305;79.2355;32.9443;41.5978;23.4636;45.5481;39.929;44.3296;106.138;32.7581;1.28142E-12;105.243;31.9156;4.70178;245.492;22.3625;45.5891;34.8042;36.7081;37.4625;15.4235;81.7848 0 Exp 2,16(0.44);Exp 3,1(0.03);Exp 4,2(0.06);Hill,4(0.11);Linear,5(0.14);Poly 2,8(0.22);Power,1(0.03) 1.9486660639288949 75.00265717506409 1.5074360370635986 4.560328960418701 0.6891160751831253 1.8264755010604858 27.60228640860334 46.22603698028562 18.899493527631215 31.594754472368855 46.98053875928939 82.53210290737736 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0006711 6 estrogen catabolic process 1 2 1 1 1 1 1 1 161 1 2384 0.99598 0.12319 0.12319 50.0 360268 sult1e1 SULT1E1_32446 50.1846 50.1846 50.1846 50.1846 36.5009 36.5009 36.5009 36.5009 80.9788 80.9788 80.9788 80.97880000000002 0.0 50.1846 0.0 50.1846 50.1846 36.5009 80.9788 1 0 1 360268 SULT1E1_32446 50.1846 50.1846 36.5009 36.5009 80.9788 80.9788 50.1846 36.5009 80.9788 0 0 Exp 2,1(1) 1.7401635646820068 1.7401635646820068 1.7401635646820068 1.7401635646820068 0.0 1.7401635646820068 50.1846 50.1846 36.5009 36.5009 80.9788 80.9788 UP 1.0 0.0 0.0 GO:0010499 7 proteasomal ubiquitin-independent protein catabolic process 5 6 1 1 1 1 1 1 161 5 2380 0.9491 0.32612 0.32612 16.67 29676 psmb3 PSMB3_9589 23.7888 23.7888 23.7888 23.788799999999995 19.2724 19.2724 19.2724 19.2724 30.901 30.901 30.901 30.901 0.0 23.7888 0.0 23.7888 23.7888 19.2724 30.901 1 0 1 29676 PSMB3_9589 23.7888 23.7888 19.2724 19.2724 30.901 30.901 23.7888 19.2724 30.901 0 0 Exp 2,1(1) 1.6278724670410156 1.6278724670410156 1.6278724670410156 1.6278724670410156 0.0 1.6278724670410156 23.7888 23.7888 19.2724 19.2724 30.901 30.901 UP 1.0 0.0 0.0 GO:0072503 8 cellular divalent inorganic cation homeostasis 114 121 13 13 10 11 9 9 153 112 2273 0.76283 0.36234 0.56738 7.44 29573;25106;24567;288001;81678;81869;24890;29184;155423 slc37a4;rgn;mt1;kng1;itpr2;gstm7;esr1;cd36;anxa7 SLC37A4_9871;RGN_9699;MT1A_9255;KNG1L1_34113;ITPR2_8931;GSTM7_8761;ESR1_33192;CD36_8243;ANXA7_8051 44.97193333333334 39.7166 12.9315 29.045304532660694 49.827701243056794 26.385819733762744 29.536425555555557 24.7342 8.91033 15.210240506600412 32.7166240841695 13.648090804607335 58.23597777777778 60.0334 23.4636 28.461977987386 65.1396392290808 24.209665668822144 5.5 45.2224 39.7166;77.4407;12.9315;24.3655;31.8111;42.3152;23.3972;48.1296;104.64 22.6911;58.7732;8.91033;19.538;24.7342;31.4035;18.3088;37.5433;43.9254 60.0334;89.8047;23.4636;32.1467;44.3296;64.5991;31.9156;69.1421;108.689 4 5 4 25106;81869;29184;155423 RGN_9699;GSTM7_8761;CD36_8243;ANXA7_8051 68.131375 62.78515 28.78708695536652 42.91135 40.734350000000006 11.745540362906569 83.058725 79.4734 20.304756272094675 77.4407;42.3152;48.1296;104.64 58.7732;31.4035;37.5433;43.9254 89.8047;64.5991;69.1421;108.689 5 29573;24567;288001;81678;24890 SLC37A4_9871;MT1A_9255;KNG1L1_34113;ITPR2_8931;ESR1_33192 26.444380000000002 24.3655 10.014470545016332 18.836486 19.538 6.102053483416877 38.37778 32.1467 14.207471030130598 39.7166;12.9315;24.3655;31.8111;23.3972 22.6911;8.91033;19.538;24.7342;18.3088 60.0334;23.4636;32.1467;44.3296;31.9156 0 Exp 2,2(0.23);Exp 3,1(0.12);Linear,3(0.34);Poly 2,3(0.34) 2.0023834531992386 18.338393449783325 1.5461770296096802 2.6703107357025146 0.40554365069716525 1.893584966659546 25.99566770532834 63.94819896133832 19.59906842457663 39.47378268653449 39.64081882601894 76.83113672953662 CONFLICT 0.4444444444444444 0.5555555555555556 0.0 GO:0031329 6 regulation of cellular catabolic process 171 183 15 15 12 12 9 9 153 174 2211 0.25767 0.83845 0.52839 4.92 79426;246273;25106;192280;24464;294515;24360;25423;246142 zfp36;trib3;rgn;ppp1r3b;hp;foxo3;fabp1;ctsc;bmf ZFP36_10204;TRIB3_10079;RGN_9699;PPP1R3B_9545;HP_8823;FOXO3_8662;FABP1_33091;CTSC_32456;BMF_8152 53.89830377777777 56.2386 0.348134 36.29035160767156 61.00008773409505 30.4995653683692 39.444478000000004 38.2681 0.118102 28.49941355745335 44.72859700694655 24.077244203246707 79.65461333333333 89.8047 1.15962 48.67915955718218 90.04475976161555 41.1090441616931 0.348134;108.064;77.4407;36.1411;64.9285;13.1992;33.8478;56.2386;94.8767 0.118102;83.8836;58.7732;27.0588;41.6103;5.6804;26.4736;38.2681;73.1342 1.15962;143.428;89.8047;53.6244;136.455;32.7581;46.9257;102.888;109.848 3 6 3 25106;24360;246142 RGN_9699;FABP1_33091;BMF_8152 68.72173333333333 77.4407 31.434804653494094 52.793666666666674 58.7732 23.8980964148472 82.19279999999999 89.8047 32.144357600207236 77.4407;33.8478;94.8767 58.7732;26.4736;73.1342 89.8047;46.9257;109.848 6 79426;246273;192280;24464;294515;25423 ZFP36_10204;TRIB3_10079;PPP1R3B_9545;HP_8823;FOXO3_8662;CTSC_32456 46.486589 46.18985 38.91225972418572 32.769883666666665 32.66345 30.178107260665644 78.38552 78.2562 58.07198014273665 0.348134;108.064;36.1411;64.9285;13.1992;56.2386 0.118102;83.8836;27.0588;41.6103;5.6804;38.2681 1.15962;143.428;53.6244;136.455;32.7581;102.888 0 Exp 2,4(0.45);Exp 4,1(0.12);Hill,1(0.12);Poly 2,3(0.34) 1.7933117540825958 16.18722379207611 1.5736411809921265 1.9883413314819336 0.14476748747382207 1.8753424882888794 30.18860739409904 77.60800016145652 20.82486114246381 58.0640948575362 47.85089575597432 111.45833091069237 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0071361 6 cellular response to ethanol 11 15 2 2 2 2 2 2 160 13 2372 0.93468 0.24652 0.24652 13.33 286954;81678 ugt2b1;itpr2 UGT2B10_33303,UGT2B1_33224;ITPR2_8931 39.642275 39.642275 31.8111 11.074953894317131 39.849355803752616 11.07108119574075 29.781675 29.781675 24.7342 7.138207600739134 29.91514605382286 7.135711506698737 60.402175 60.402175 44.3296 22.73005354725876 60.82718424182823 22.72210528428148 0.0 31.8111 0.5 39.642275 47.47345;31.8111 34.82915;24.7342 76.47475;44.3296 2 1 1 286954 UGT2B10_33303,UGT2B1_33224 47.47345 47.47345 34.82915 34.82915 76.47475 76.47475 47.47345 34.82915 76.47475 1 81678 ITPR2_8931 31.8111 31.8111 24.7342 24.7342 44.3296 44.3296 31.8111 24.7342 44.3296 0 Exp 2,2(0.67);Linear,1(0.34) 1.6932312640743177 5.082504630088806 1.6419988870620728 1.7730062007904053 0.06945604684964038 1.6674995422363281 24.293172 54.991378 19.888624000000004 39.67472599999999 28.899928000000006 91.904422 CONFLICT 0.5 0.5 0.0 GO:0030224 7 monocyte differentiation 8 8 2 2 2 2 2 2 160 6 2379 0.98885 0.087405 0.087405 25.0 363465;24516 pir;jun PIR_9487;JUN_8938 33.23155 33.23155 16.4324 23.757585766339986 39.43559547226653 22.078100484441553 24.64705 24.64705 10.5224 19.975271593773147 29.863383616870465 18.563167898826276 56.468650000000004 56.468650000000004 39.929 23.39059734690416 62.57686027822081 21.73705542705993 0.0 16.4324 0.0 16.4324 50.0307;16.4324 38.7717;10.5224 73.0083;39.929 1 1 1 363465 PIR_9487 50.0307 50.0307 38.7717 38.7717 73.0083 73.0083 50.0307 38.7717 73.0083 1 24516 JUN_8938 16.4324 16.4324 10.5224 10.5224 39.929 39.929 16.4324 10.5224 39.929 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.937284445454501 3.875427722930908 1.8969218730926514 1.9785058498382568 0.05768858319298323 1.937713861465454 0.3052160000000015 66.157884 -3.0372640000000004 52.331364 24.050936 88.88636400000001 CONFLICT 0.5 0.5 0.0 GO:0048869 3 cellular developmental process 541 573 54 54 39 47 34 34 128 539 1846 0.3577 0.71292 0.69771 5.93 308843;24825;362895;29573;246074;297784;83516;303612;85253;363465;25513;81819;307582;24516;494344;65164;29540;25675;294515;314322;25661;80841;24890;29496;24330;116663;140942;25146;497840;25695;114851;79431;155423;24158 tsku;tf;stac3;slc37a4;scd;rrs1;ppargc1a;polg2;plg;pir;pik3r1;pax8;lama3;jun;ier2;htra1;hsd17b7;hmgcr;foxo3;fos;fn1;fabp7;esr1;erbb3;egr1;dusp6;ddit4;cyp17a1;cps1;cebpd;cdkn1a;bhlhe40;anxa7;acadm TSKU_10094;TF_10003;STAC3_9953;SLC37A4_9871;SCD1_9787;RRS1_9755;PPARGC1A_33189;POLG2_9521;PLG_9501;PIR_9487;PIK3R1_32562;PAX8_9432;LAMA3_8980;JUN_8938;IER2_32643;HTRA1_8856;HSD17B7_8834;HMGCR_8810;FOXO3_8662;FOS_8657;FN1_8655;FABP7_8592;ESR1_33192;ERBB3_8571;EGR1_8533;DUSP6_8506;DDIT4_8450;CYP17A1_32365;CPS1_32421;CEBPD_8283;CDKN1A_8271;BHLHE40_8141;ANXA7_8051;ACADM_7957 38.73962932352945 41.063 1.28141E-12 30.29532412663819 42.32693004254652 28.053528128830838 24.656873564705922 25.95665 1.28141E-12 18.613375031874696 27.072835154090725 17.276724421280637 77.19777676470594 60.78375 1.28142E-12 81.80614676122184 79.47380488092159 72.2147345374871 27.5 62.81635 1.38416;45.1539;63.2393;39.7166;105.46;60.39;42.4094;63.7758;70.7857;50.0307;18.7324;56.8931;2.46923;16.4324;49.6814;33.1323;0.977494;1.63089;13.1992;1.28141E-12;59.5777;24.601;23.3972;60.9984;0.750017;62.3934;87.5421;49.6922;31.9826;0.306936;6.24967;57.8085;104.64;11.7137 0.540568;28.132;42.7031;22.6911;63.7532;43.109;26.2988;40.9553;46.2356;38.7717;11.6701;45.1162;0.871501;10.5224;33.4626;25.6145;0.322682;0.663137;5.6804;1.28141E-12;31.0499;14.4402;18.3088;41.6036;0.186019;39.0875;53.2453;35.6654;24.4836;0.0732342;2.44025;38.3491;43.9254;8.36151 4.10872;61.5341;121.52;60.0334;422.699;104.942;81.7305;132.567;150.579;73.0083;41.5978;81.5688;10.4175;39.929;89.4404;46.6629;5.49472;7.6286;32.7581;1.28142E-12;105.243;35.6155;31.9156;113.972;4.70178;133.304;245.492;81.6409;45.5891;1.73689;19.0606;110.58;108.689;18.9642 10 24 10 24825;246074;297784;363465;81819;80841;29496;25146;155423;24158 TF_10003;SCD1_9787;RRS1_9755;PIR_9487;PAX8_9432;FABP7_8592;ERBB3_8571;CYP17A1_32365;ANXA7_8051;ACADM_7957 56.9573 53.4619 29.792361128502574 36.287821 40.187650000000005 15.971077296474569 110.26338000000001 81.60485 114.0046400223332 45.1539;105.46;60.39;50.0307;56.8931;24.601;60.9984;49.6922;104.64;11.7137 28.132;63.7532;43.109;38.7717;45.1162;14.4402;41.6036;35.6654;43.9254;8.36151 61.5341;422.699;104.942;73.0083;81.5688;35.6155;113.972;81.6409;108.689;18.9642 24 308843;362895;29573;83516;303612;85253;25513;307582;24516;494344;65164;29540;25675;294515;314322;25661;24890;24330;116663;140942;497840;25695;114851;79431 TSKU_10094;STAC3_9953;SLC37A4_9871;PPARGC1A_33189;POLG2_9521;PLG_9501;PIK3R1_32562;LAMA3_8980;JUN_8938;IER2_32643;HTRA1_8856;HSD17B7_8834;HMGCR_8810;FOXO3_8662;FOS_8657;FN1_8655;ESR1_33192;EGR1_8533;DUSP6_8506;DDIT4_8450;CPS1_32421;CEBPD_8283;CDKN1A_8271;BHLHE40_8141 31.148933208333386 27.6899 27.660734692979958 19.810645466666717 20.49995 17.71878845273684 63.42044208333338 43.593450000000004 61.98936965895553 1.38416;63.2393;39.7166;42.4094;63.7758;70.7857;18.7324;2.46923;16.4324;49.6814;33.1323;0.977494;1.63089;13.1992;1.28141E-12;59.5777;23.3972;0.750017;62.3934;87.5421;31.9826;0.306936;6.24967;57.8085 0.540568;42.7031;22.6911;26.2988;40.9553;46.2356;11.6701;0.871501;10.5224;33.4626;25.6145;0.322682;0.663137;5.6804;1.28141E-12;31.0499;18.3088;0.186019;39.0875;53.2453;24.4836;0.0732342;2.44025;38.3491 4.10872;121.52;60.0334;81.7305;132.567;150.579;41.5978;10.4175;39.929;89.4404;46.6629;5.49472;7.6286;32.7581;1.28142E-12;105.243;31.9156;4.70178;133.304;245.492;45.5891;1.73689;19.0606;110.58 0 Exp 2,11(0.33);Exp 3,1(0.03);Exp 4,5(0.15);Hill,5(0.15);Linear,6(0.18);Poly 2,5(0.15);Power,1(0.03) 1.887033894799689 65.86238181591034 1.522104263305664 4.21828556060791 0.5288286919757195 1.772010862827301 28.556243084191205 48.923015562867675 18.40022529862683 30.913521830785 49.69968545070633 104.69586807870544 DOWN 0.29411764705882354 0.7058823529411765 0.0 GO:0016051 5 carbohydrate biosynthetic process 27 32 7 7 4 6 3 3 159 29 2356 0.85787 0.33306 0.45354 9.38 25106;83516;24158 rgn;ppargc1a;acadm RGN_9699;PPARGC1A_33189;ACADM_7957 43.854600000000005 42.4094 11.7137 32.88732407068109 47.11644137931035 31.525189296904063 31.144503333333336 26.2988 8.36151 25.552793443379787 33.37224538914278 24.87930517997743 63.4998 81.7305 18.9642 38.77967156810382 68.46644459908602 35.970569309775435 0.5 27.061549999999997 77.4407;42.4094;11.7137 58.7732;26.2988;8.36151 89.8047;81.7305;18.9642 2 1 2 25106;24158 RGN_9699;ACADM_7957 44.577200000000005 44.577200000000005 46.47600740704821 33.567355 33.567355 35.646447850074075 54.38445 54.38445 50.09179793264562 77.4407;11.7137 58.7732;8.36151 89.8047;18.9642 1 83516 PPARGC1A_33189 42.4094 42.4094 26.2988 26.2988 81.7305 81.7305 42.4094 26.2988 81.7305 0 Exp 2,1(0.34);Poly 2,2(0.67) 1.723320521236868 5.170570731163025 1.693061113357544 1.7576230764389038 0.03243428418626304 1.7198865413665771 6.639089405936993 81.07011059406301 2.2287954740921663 60.0602111925745 19.616470514897166 107.38312948510284 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0018205 8 peptidyl-lysine modification 36 39 2 2 2 2 2 2 160 37 2348 0.5439 0.72107 1.0 5.13 293615;29441 sirt3;por SIRT3_9828;POR_9531 7.41079 7.41079 2.38018 7.114356889009714 7.876322470692718 7.083828977443024 4.52595 4.52595 0.56209 5.605744571348217 4.892765463587922 5.581690158952356 44.032335 44.032335 8.82917 49.78479338145785 47.290034638543524 49.57116539042144 0.5 7.41079 2.38018;12.4414 0.56209;8.48981 8.82917;79.2355 1 1 1 293615 SIRT3_9828 2.38018 2.38018 0.56209 0.56209 8.82917 8.82917 2.38018 0.56209 8.82917 1 29441 POR_9531 12.4414 12.4414 8.48981 8.48981 79.2355 79.2355 12.4414 8.48981 79.2355 0 Hill,1(0.5);Poly 2,1(0.5) 1.7362193584744778 3.5029003620147705 1.5209722518920898 1.9819281101226807 0.3259450131825156 1.7514501810073853 -2.449205599999998 17.270785599999996 -3.243215600000001 12.2951156 -24.965868399999984 113.03053839999998 CONFLICT 0.5 0.5 0.0 GO:0043651 8 linoleic acid metabolic process 10 12 7 7 5 5 3 3 159 9 2376 0.99478 0.036309 0.036309 25.0 81869;65030;65210 gstm7;ephx2;cyp2j4 GSTM7_8761;EPHX2_33282;CYP2J4_32580 32.961333333333336 38.7293 17.8395 13.218057808291407 31.234320340392507 13.682384635380917 25.087766666666667 29.2097 14.6501 9.105594636998363 23.900948907861185 9.433948354146235 48.14176666666666 57.2113 22.6149 22.413401985716806 45.20160887016299 23.158004701139088 0.0 17.8395 0.5 28.2844 42.3152;38.7293;17.8395 31.4035;29.2097;14.6501 64.5991;57.2113;22.6149 3 0 3 81869;65030;65210 GSTM7_8761;EPHX2_33282;CYP2J4_32580 32.961333333333336 38.7293 13.218057808291407 25.087766666666667 29.2097 9.105594636998363 48.14176666666666 57.2113 22.413401985716806 42.3152;38.7293;17.8395 31.4035;29.2097;14.6501 64.5991;57.2113;22.6149 0 0 Linear,3(1) 3.1394624303900516 10.201096177101135 1.7501527070999146 4.642963409423828 1.4888588677826777 3.8079800605773926 18.003692835122425 47.91897383154425 14.783816337653537 35.3917169956798 22.778614673645254 73.50491865968809 UP 1.0 0.0 0.0 GO:1990966 4 ATP generation from poly-ADP-D-ribose 2 2 2 2 2 2 2 2 160 0 2385 1.0 0.0040221 0.0040221 100.0 25591;361239 parp1;bphl PARP1_9425;BPHL_8157 19.64465 19.64465 12.3152 10.365407594735487 19.957519502326527 10.355959634627192 14.20265 14.20265 6.6063 10.74286119453286 14.526912563220717 10.733069189434447 30.3924 30.3924 25.5051 6.911685943386034 30.601022354845238 6.905386014273021 0.0 12.3152 0.0 12.3152 26.9741;12.3152 21.799;6.6063 35.2797;25.5051 2 0 2 25591;361239 PARP1_9425;BPHL_8157 19.64465 19.64465 10.365407594735487 14.20265 14.20265 10.74286119453286 30.3924 30.3924 6.911685943386034 26.9741;12.3152 21.799;6.6063 35.2797;25.5051 0 0 Exp 2,1(0.5);Exp 4,1(0.5) 1.7308878319545276 3.4651206731796265 1.6564509868621826 1.8086696863174438 0.10763487460821225 1.7325603365898132 5.278927999999999 34.010372 -0.6861959999999989 29.091496 20.813292 39.971508 UP 1.0 0.0 0.0 GO:0050850 8 positive regulation of calcium-mediated signaling 20 21 2 2 2 2 2 2 160 19 2366 0.85485 0.39001 0.39001 9.52 81869;29496 gstm7;erbb3 GSTM7_8761;ERBB3_8571 51.6568 51.6568 42.3152 13.211017414264486 52.61360579658287 13.14153820735046 36.503550000000004 36.503550000000004 31.4035 7.212559878780878 37.025918481080595 7.174627679883244 89.28555 89.28555 64.5991 34.91191239684527 91.81403960103765 34.72830413193087 0.5 51.6568 42.3152;60.9984 31.4035;41.6036 64.5991;113.972 2 0 2 81869;29496 GSTM7_8761;ERBB3_8571 51.6568 51.6568 13.211017414264486 36.503550000000004 36.503550000000004 7.212559878780878 89.28555 89.28555 34.91191239684527 42.3152;60.9984 31.4035;41.6036 64.5991;113.972 0 0 Linear,2(1) 1.6740741088255686 3.351455330848694 1.6013026237487793 1.7501527070999146 0.10525290331777055 1.675727665424347 33.347263999999996 69.966336 26.507452000000008 46.499648 40.90010800000002 137.67099199999998 UP 1.0 0.0 0.0 GO:0070327 6 thyroid hormone transport 3 3 2 2 2 2 2 2 160 1 2384 0.99975 0.011561 0.011561 66.67 24856;25303 ttr;abcc2 TTR_10102;ABCC2_32541 46.436099999999996 46.436099999999996 46.2316 0.2892066735068726 46.49598545181852 0.276528416843383 29.8832 29.8832 28.5876 1.8322550914105589 29.503798575178102 1.751932600782945 72.7497 72.7497 63.7146 12.777560957397121 70.10387581552305 12.217417599054048 0.0 46.2316 0.0 46.2316 46.6406;46.2316 28.5876;31.1788 63.7146;81.7848 1 1 1 24856 TTR_10102 46.6406 46.6406 28.5876 28.5876 63.7146 63.7146 46.6406 28.5876 63.7146 1 25303 ABCC2_32541 46.2316 46.2316 31.1788 31.1788 81.7848 81.7848 46.2316 31.1788 81.7848 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.8916212350351385 3.78381609916687 1.8589661121368408 1.9248499870300293 0.046586934707819695 1.891908049583435 46.03528 46.83691999999999 27.343823999999998 32.422576 55.040904 90.45849600000001 CONFLICT 0.5 0.5 0.0 GO:0042908 5 xenobiotic transport 11 11 5 5 4 4 3 3 159 8 2377 0.99634 0.028536 0.028536 27.27 312382;140668;25303 abcg2;abcc3;abcc2 ABCG2_32656;ABCC3_7941;ABCC2_32541 29.72188 37.7175 5.21654 21.645004991664933 24.003724231897664 22.414336802948473 21.604393333333334 30.9007 2.73368 16.343108675650825 17.44400105738763 17.3076539107802 47.3679 48.9329 11.386 35.22548337652728 38.18423621053867 34.639619607220254 0.0 5.21654 0.5 21.46702 5.21654;37.7175;46.2316 2.73368;30.9007;31.1788 11.386;48.9329;81.7848 2 1 2 312382;140668 ABCG2_32656;ABCC3_7941 21.46702 21.46702 22.981649211072728 16.81719 16.81719 19.91709084781711 30.15945 30.15945 26.549667602533173 5.21654;37.7175 2.73368;30.9007 11.386;48.9329 1 25303 ABCC2_32541 46.2316 46.2316 31.1788 31.1788 81.7848 81.7848 46.2316 31.1788 81.7848 0 Exp 2,2(0.67);Exp 4,1(0.34) 2.04192754970604 6.404561996459961 1.5074360370635986 3.0381598472595215 0.8017882764726921 1.8589661121368408 5.228251061244851 54.21550893875515 3.110424874499998 40.09836179216667 7.506513072845472 87.22928692715453 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0006826 9 iron ion transport 11 11 3 3 3 2 2 2 160 9 2376 0.97146 0.15174 0.15174 18.18 24825;304929 tf;f5 TF_10003;F5_33079 27.8814 27.8814 10.6089 24.427003756089288 37.91311186440678 19.884869288960417 15.361645000000001 15.361645000000001 2.59129 18.060009237319065 22.778551745762712 14.701799968077701 49.52095 49.52095 37.5078 16.98915965682237 56.49807892655368 13.830071935080268 0.0 10.6089 0.5 27.8814 45.1539;10.6089 28.132;2.59129 61.5341;37.5078 1 1 1 24825 TF_10003 45.1539 45.1539 28.132 28.132 61.5341 61.5341 45.1539 28.132 61.5341 1 304929 F5_33079 10.6089 10.6089 2.59129 2.59129 37.5078 37.5078 10.6089 2.59129 37.5078 0 Hill,1(0.5);Poly 2,1(0.5) 1.7681513725285625 3.5387003421783447 1.7042291164398193 1.8344712257385254 0.09209507868115455 1.7693501710891724 -5.972699999999996 61.735499999999995 -9.668250799999997 40.3915408 25.975176 73.066724 CONFLICT 0.5 0.5 0.0 GO:0043523 7 regulation of neuron apoptotic process 110 113 14 14 12 13 11 11 151 102 2283 0.94807 0.10031 0.16239 9.73 83516;25591;24314;24567;24516;192235;63868;294515;24890;29496;24330 ppargc1a;parp1;nqo1;mt1;jun;hyou1;hspd1;foxo3;esr1;erbb3;egr1 PPARGC1A_33189;PARP1_9425;NQO1_33055;MT1A_9255;JUN_8938;HYOU1_8857;HSPD1_8849;FOXO3_8662;ESR1_33192;ERBB3_8571;EGR1_8533 33.34771063636364 26.9741 0.750017 24.884667797797196 32.07408876906202 21.307934640195064 22.485440818181818 21.799 0.186019 17.363915829903505 21.502203443971723 14.45632463943815 65.96430727272727 39.929 4.70178 55.25796748991933 61.77881441556429 44.8109735519832 4.5 25.185650000000003 42.4094;26.9741;87.2765;12.9315;16.4324;40.1982;42.2579;13.1992;23.3972;60.9984;0.750017 26.2988;21.799;60.6992;8.91033;10.5224;29.3844;23.9469;5.6804;18.3088;41.6036;0.186019 81.7305;35.2797;197.117;23.4636;39.929;62.3571;102.383;32.7581;31.9156;113.972;4.70178 4 7 4 25591;24314;63868;29496 PARP1_9425;NQO1_33055;HSPD1_8849;ERBB3_8571 54.376725 51.62815 25.97442043708579 37.012175 32.77525 18.11351651196329 112.187925 108.1775 66.40065845774798 26.9741;87.2765;42.2579;60.9984 21.799;60.6992;23.9469;41.6036 35.2797;197.117;102.383;113.972 7 83516;24567;24516;192235;294515;24890;24330 PPARGC1A_33189;MT1A_9255;JUN_8938;HYOU1_8857;FOXO3_8662;ESR1_33192;EGR1_8533 21.331131 16.4324 15.213975370341586 14.184449857142857 10.5224 10.834421286565188 39.55081142857143 32.7581 25.420092768482334 42.4094;12.9315;16.4324;40.1982;13.1992;23.3972;0.750017 26.2988;8.91033;10.5224;29.3844;5.6804;18.3088;0.186019 81.7305;23.4636;39.929;62.3571;32.7581;31.9156;4.70178 0 Exp 2,5(0.46);Exp 3,1(0.1);Exp 4,1(0.1);Hill,1(0.1);Linear,1(0.1);Poly 2,2(0.19) 2.0539891895058413 23.543770909309387 1.576730489730835 4.21828556060791 0.7475537965489824 1.9785058498382568 18.64181172807741 48.053609544649845 12.224022304523555 32.746859331840085 33.30893528274821 98.61967926270633 DOWN 0.36363636363636365 0.6363636363636364 0.0 GO:0071320 6 cellular response to cAMP 28 29 9 9 7 8 6 6 156 23 2362 0.99825 0.0084166 0.0084166 20.69 24825;81678;24330;497840;25698;65054 tf;itpr2;egr1;cps1;ass1;aqp9 TF_10003;ITPR2_8931;EGR1_8533;CPS1_32421;ASS1_33159;AQP9_32709 27.372152833333335 29.771349999999998 0.750017 14.603708190333988 27.787893292518003 15.643405851262663 20.075919833333334 23.2104 0.186019 10.059046205598232 20.082191189421 10.680224633079423 38.38753 40.89605 4.70178 18.76880618368148 39.120376013114 20.09566724409742 0.5 13.7768585 1.5 27.26765 45.1539;31.8111;0.750017;31.9826;26.8037;27.7316 28.132;24.7342;0.186019;24.4836;20.9825;21.9372 61.5341;44.3296;4.70178;45.5891;36.7081;37.4625 1 5 1 24825 TF_10003 45.1539 45.1539 28.132 28.132 61.5341 61.5341 45.1539 28.132 61.5341 5 81678;24330;497840;25698;65054 ITPR2_8931;EGR1_8533;CPS1_32421;ASS1_33159;AQP9_32709 23.8158034 27.7316 13.104510919746588 18.464703800000002 21.9372 10.3445823942981 33.758216 37.4625 16.72142326840871 31.8111;0.750017;31.9826;26.8037;27.7316 24.7342;0.186019;24.4836;20.9825;21.9372 44.3296;4.70178;45.5891;36.7081;37.4625 0 Exp 2,2(0.34);Hill,1(0.17);Linear,2(0.34);Poly 2,1(0.17) 2.0782590854368714 13.24528181552887 1.6674995422363281 4.21828556060791 0.9877152788747465 1.8304733633995056 15.686752583184877 39.05755308348179 12.027006535753666 28.12483313091301 23.36935724447033 53.40570275552967 DOWN 0.16666666666666666 0.8333333333333334 0.0 GO:0034754 5 cellular hormone metabolic process 34 41 12 12 10 8 7 7 155 34 2351 0.99647 0.013232 0.013232 17.07 24856;360268;83516;29540;289456;24890;25146 ttr;sult1e1;ppargc1a;hsd17b7;hsd17b11;esr1;cyp17a1 TTR_10102;SULT1E1_32446;PPARGC1A_33189;HSD17B7_8834;HSD17B11_8832;ESR1_33192;CYP17A1_32365 33.67641342857143 42.4094 0.977494 18.59501610089638 35.396317854553445 16.791435723326302 23.401068857142857 26.2988 0.322682 12.541360449700917 24.22719444424235 10.84824040105043 53.52854571428571 63.7146 5.49472 31.1126223125593 55.43235379703965 28.775055151931344 1.5 22.915300000000002 3.5 44.525 46.6406;50.1846;42.4094;0.977494;22.4334;23.3972;49.6922 28.5876;36.5009;26.2988;0.322682;18.1233;18.3088;35.6654 63.7146;80.9788;81.7305;5.49472;29.2247;31.9156;81.6409 4 3 4 24856;360268;289456;25146 TTR_10102;SULT1E1_32446;HSD17B11_8832;CYP17A1_32365 42.237700000000004 48.166399999999996 13.29559597210042 29.719299999999997 32.1265 8.506745649972936 63.88975000000001 72.3467 24.55494061114109 46.6406;50.1846;22.4334;49.6922 28.5876;36.5009;18.1233;35.6654 63.7146;80.9788;29.2247;81.6409 3 83516;29540;24890 PPARGC1A_33189;HSD17B7_8834;ESR1_33192 22.261364666666665 23.3972 20.739293626508722 14.976760666666669 18.3088 13.304756336612906 39.71360666666667 31.9156 38.711499829277265 42.4094;0.977494;23.3972 26.2988;0.322682;18.3088 81.7305;5.49472;31.9156 0 Exp 2,3(0.43);Exp 4,1(0.15);Linear,2(0.29);Poly 2,1(0.15) 1.900504646119802 13.389129877090454 1.7248681783676147 2.436986207962036 0.24645420094719334 1.8952336311340332 19.901032724671566 47.45179413247128 14.110299018490508 32.691838695795205 30.47999255753458 76.57709887103684 CONFLICT 0.5714285714285714 0.42857142857142855 0.0 GO:0042413 7 carnitine catabolic process 1 1 1 1 1 1 1 1 161 0 2385 1.0 0.063604 0.063604 100.0 25287 acadl ACADL_32776 33.4878 33.4878 33.4878 33.4878 26.6039 26.6039 26.6039 26.6039 45.3228 45.3228 45.3228 45.3228 0.0 33.4878 0.0 33.4878 33.4878 26.6039 45.3228 1 0 1 25287 ACADL_32776 33.4878 33.4878 26.6039 26.6039 45.3228 45.3228 33.4878 26.6039 45.3228 0 0 Exp 2,1(1) 1.8872262239456177 1.8872262239456177 1.8872262239456177 1.8872262239456177 0.0 1.8872262239456177 33.4878 33.4878 26.6039 26.6039 45.3228 45.3228 UP 1.0 0.0 0.0 GO:0060249 5 anatomical structure homeostasis 62 66 3 3 3 2 2 2 160 64 2321 0.19729 0.93084 0.43745 3.03 85253;25591 plg;parp1 PLG_9501;PARP1_9425 48.879900000000006 48.879900000000006 26.9741 30.979479454632525 49.045810423620026 30.97859090957283 34.0173 34.0173 21.799 17.27928556914319 34.109839114249034 17.278789969342984 92.92935 92.92935 35.2797 81.52891689606211 93.36597764441592 81.5265785056951 70.7857;26.9741 46.2356;21.799 150.579;35.2797 1 1 1 25591 PARP1_9425 26.9741 26.9741 21.799 21.799 35.2797 35.2797 26.9741 21.799 35.2797 1 85253 PLG_9501 70.7857 70.7857 46.2356 46.2356 150.579 150.579 70.7857 46.2356 150.579 0 Exp 2,1(0.5);Linear,1(0.5) 1.6610447479705555 3.3341387510299683 1.5254690647125244 1.8086696863174438 0.200253079973084 1.6670693755149841 5.944532000000002 91.815268 10.069432000000006 57.96516799999999 -20.063964 205.922664 CONFLICT 0.5 0.5 0.0 GO:0051090 7 regulation of DNA-binding transcription factor activity 109 115 9 9 8 8 7 7 155 108 2277 0.54958 0.60641 1.0 6.09 83516;81525;25493;24516;24890;29184;79431 ppargc1a;nfkbib;nfkbia;jun;esr1;cd36;bhlhe40 PPARGC1A_33189;NFKBIB_9308;NFKBIA_9307;JUN_8938;ESR1_33192;CD36_8243;BHLHE40_8141 31.32206442857143 30.5572 0.520151 19.75180161740418 35.98665996722955 14.796061788738479 22.203786 24.2439 0.160202 13.871123176670734 26.340269437889656 11.02314379071089 53.92047 41.2611 2.88499 35.73106382496842 58.04302160343368 25.90362075471852 4.5 45.2695 42.4094;30.5572;0.520151;16.4324;23.3972;48.1296;57.8085 26.2988;24.2439;0.160202;10.5224;18.3088;37.5433;38.3491 81.7305;41.2611;2.88499;39.929;31.9156;69.1421;110.58 2 5 2 81525;29184 NFKBIB_9308;CD36_8243 39.3434 39.3434 12.42556320172248 30.8936 30.8936 9.404095925712369 55.2016 55.2016 19.714844166262157 30.5572;48.1296 24.2439;37.5433 41.2611;69.1421 5 83516;25493;24516;24890;79431 PPARGC1A_33189;NFKBIA_9307;JUN_8938;ESR1_33192;BHLHE40_8141 28.113530200000003 23.3972 22.395592611835706 18.7278604 18.3088 14.61655996054957 53.408018000000006 39.929 42.62330004958696 42.4094;0.520151;16.4324;23.3972;57.8085 26.2988;0.160202;10.5224;18.3088;38.3491 81.7305;2.88499;39.929;31.9156;110.58 0 Exp 2,5(0.72);Exp 4,1(0.15);Poly 2,1(0.15) 1.9556767904779928 13.93196451663971 1.5302108526229858 2.6703107357025146 0.414013449498013 1.8546061515808105 16.68972502153368 45.954403835609185 11.927914147427796 32.4796578525722 27.450527491020047 80.39041250897998 DOWN 0.2857142857142857 0.7142857142857143 0.0 GO:1902533 7 positive regulation of intracellular signal transduction 254 269 14 14 12 13 11 11 151 258 2127 0.063397 0.96597 0.11371 4.09 24825;24516;25675;81869;29455;299626;25112;361969;24890;29496;29184 tf;jun;hmgcr;gstm7;gdf15;gadd45b;gadd45a;fga;esr1;erbb3;cd36 TF_10003;JUN_8938;HMGCR_8810;GSTM7_8761;GDF15_33113;GADD45B_8679;GADD45A_8678;FGA_8632;ESR1_33192;ERBB3_8571;CD36_8243 52.824808181818184 45.1539 1.63089 37.109523871840985 58.820999384996284 33.35351976314379 38.02443972727273 31.4035 0.663137 28.35663142908164 44.9710289867459 28.590575416157318 70.73587272727274 64.5991 7.6286 39.95121508437736 78.65261664933564 35.74228024283799 45.1539;16.4324;1.63089;42.3152;105.149;106.367;102.919;28.5803;23.3972;60.9984;48.1296 28.132;10.5224;0.663137;31.4035;85.3487;52.7132;89.5012;22.529;18.3088;41.6036;37.5433 61.5341;39.929;7.6286;64.5991;125.652;109.434;115.437;38.8511;31.9156;113.972;69.1421 5 6 5 24825;81869;299626;29496;29184 TF_10003;GSTM7_8761;GADD45B_8679;ERBB3_8571;CD36_8243 60.59282 48.1296 26.56691338021786 38.27912 37.5433 9.619959179591172 83.73625999999999 69.1421 25.7231905198986 45.1539;42.3152;106.367;60.9984;48.1296 28.132;31.4035;52.7132;41.6036;37.5433 61.5341;64.5991;109.434;113.972;69.1421 6 24516;25675;29455;25112;361969;24890 JUN_8938;HMGCR_8810;GDF15_33113;GADD45A_8678;FGA_8632;ESR1_33192 46.351465 25.988750000000003 45.595677435486685 37.81220616666666 20.4189 39.16686465079312 59.90221666666667 39.39005 48.50774531360602 16.4324;1.63089;105.149;102.919;28.5803;23.3972 10.5224;0.663137;85.3487;89.5012;22.529;18.3088 39.929;7.6286;125.652;115.437;38.8511;31.9156 0 Exp 2,2(0.19);Exp 4,1(0.1);Linear,3(0.28);Poly 2,4(0.37);Power,1(0.1) 1.8294997259093226 20.462690353393555 1.541895866394043 2.6703107357025146 0.37699921273560477 1.7501527070999146 30.89448100090897 74.75513536272739 21.266741430310915 54.78213802423454 47.12621335516487 94.34553209938059 CONFLICT 0.45454545454545453 0.5454545454545454 0.0 GO:0007162 6 negative regulation of cell adhesion 83 86 7 7 6 7 6 6 156 80 2305 0.69525 0.4698 0.8205 6.98 85253;25513;288001;246186;29496;25698 plg;pik3r1;kng1;fgl1;erbb3;ass1 PLG_9501;PIK3R1_32562;KNG1L1_34113;FGL1_8640;ERBB3_8571;ASS1_33159 36.19356666666667 25.584600000000002 15.4757 23.554577232093685 38.999875646234464 25.793235020996008 25.0406 20.26025 10.2138 15.289944701404249 26.46596735559088 16.856249446641186 67.56903333333334 39.152950000000004 30.4106 51.58736844440377 75.51226927810164 55.730078690690085 3.5 43.90105 70.7857;18.7324;24.3655;15.4757;60.9984;26.8037 46.2356;11.6701;19.538;10.2138;41.6036;20.9825 150.579;41.5978;32.1467;30.4106;113.972;36.7081 1 5 1 29496 ERBB3_8571 60.9984 60.9984 41.6036 41.6036 113.972 113.972 60.9984 41.6036 113.972 5 85253;25513;288001;246186;25698 PLG_9501;PIK3R1_32562;KNG1L1_34113;FGL1_8640;ASS1_33159 31.2326 24.3655 22.559669960351815 21.728 19.538 14.48889645607974 58.28844 36.7081 51.77451239879522 70.7857;18.7324;24.3655;15.4757;26.8037 46.2356;11.6701;19.538;10.2138;20.9825 150.579;41.5978;32.1467;30.4106;36.7081 0 Exp 2,1(0.17);Linear,3(0.5);Poly 2,2(0.34) 1.7391487508948535 10.573515176773071 1.511321783065796 2.3804118633270264 0.3313984040894609 1.637441337108612 17.345979526968158 55.04115380636518 12.806096180154835 37.27510381984516 26.290541578497077 108.84752508816959 DOWN 0.16666666666666666 0.8333333333333334 0.0 GO:0033554 4 cellular response to stress 394 417 37 37 32 30 26 26 136 391 1994 0.5066 0.58072 1.0 6.24 79426;246273;83516;303612;25513;25591;24314;58954;24516;81678;192235;63868;24471;24957;25112;294515;314322;24360;116636;24330;140942;114851;29184;246142;25698;170465 zfp36;trib3;ppargc1a;polg2;pik3r1;parp1;nqo1;klf6;jun;itpr2;hyou1;hspd1;hspb1;glul;gadd45a;foxo3;fos;fabp1;eif4ebp1;egr1;ddit4;cdkn1a;cd36;bmf;ass1;acaa2 ZFP36_10204;TRIB3_10079;PPARGC1A_33189;POLG2_9521;PIK3R1_32562;PARP1_9425;NQO1_33055;KLF6_8969;JUN_8938;ITPR2_8931;HYOU1_8857;HSPD1_8849;HSPB1_8847;GLUL_32832;GADD45A_8678;FOXO3_8662;FOS_8657;FABP1_33091;EIF4EBP1_8550;EGR1_8533;DDIT4_8450;CDKN1A_8271;CD36_8243;BMF_8152;ASS1_33159;ACAA2_7955 43.75387003846159 32.82945 1.28141E-12 34.377478372029486 46.26383039071328 34.22221375494039 30.77126811538466 24.34055 1.28141E-12 25.690403972629284 33.48040124546534 26.582088300353615 72.74726153846157 46.2369 1.28142E-12 59.926193755370186 68.20049565092222 47.13073301176718 19.5 85.5883 0.348134;108.064;42.4094;63.7758;18.7324;26.9741;87.2765;18.9476;16.4324;31.8111;40.1982;42.2579;89.1011;26.4669;102.919;13.1992;1.28141E-12;33.8478;83.9001;0.750017;87.5421;6.24967;48.1296;94.8767;26.8037;26.5872 0.118102;83.8836;26.2988;40.9553;11.6701;21.799;60.6992;11.6941;10.5224;24.7342;29.3844;23.9469;60.3265;21.0456;89.5012;5.6804;1.28141E-12;26.4736;42.4185;0.186019;53.2453;2.44025;37.5433;73.1342;20.9825;21.3695 1.15962;143.428;81.7305;132.567;41.5978;35.2797;197.117;45.5481;39.929;44.3296;62.3571;102.383;106.138;35.4303;115.437;32.7581;1.28142E-12;46.9257;107.32;4.70178;245.492;19.0606;69.1421;109.848;36.7081;35.0407 8 18 8 25591;24314;63868;24360;116636;29184;246142;170465 PARP1_9425;NQO1_33055;HSPD1_8849;FABP1_33091;EIF4EBP1_8550;CD36_8243;BMF_8152;ACAA2_7955 55.481237500000006 45.19375 28.57322439667384 38.423024999999996 32.00845 19.41045099216621 87.882025 85.76255 54.235877080285675 26.9741;87.2765;42.2579;33.8478;83.9001;48.1296;94.8767;26.5872 21.799;60.6992;23.9469;26.4736;42.4185;37.5433;73.1342;21.3695 35.2797;197.117;102.383;46.9257;107.32;69.1421;109.848;35.0407 18 79426;246273;83516;303612;25513;58954;24516;81678;192235;24471;24957;25112;294515;314322;24330;140942;114851;25698 ZFP36_10204;TRIB3_10079;PPARGC1A_33189;POLG2_9521;PIK3R1_32562;KLF6_8969;JUN_8938;ITPR2_8931;HYOU1_8857;HSPB1_8847;GLUL_32832;GADD45A_8678;FOXO3_8662;FOS_8657;EGR1_8533;DDIT4_8450;CDKN1A_8271;ASS1_33159 38.541706722222294 26.6353 36.17036697196203 27.370487277777848 21.01405 27.850431932461365 66.02070000000008 42.9637 62.56341585041939 0.348134;108.064;42.4094;63.7758;18.7324;18.9476;16.4324;31.8111;40.1982;89.1011;26.4669;102.919;13.1992;1.28141E-12;0.750017;87.5421;6.24967;26.8037 0.118102;83.8836;26.2988;40.9553;11.6701;11.6941;10.5224;24.7342;29.3844;60.3265;21.0456;89.5012;5.6804;1.28141E-12;0.186019;53.2453;2.44025;20.9825 1.15962;143.428;81.7305;132.567;41.5978;45.5481;39.929;44.3296;62.3571;106.138;35.4303;115.437;32.7581;1.28142E-12;4.70178;245.492;19.0606;36.7081 0 Exp 2,9(0.35);Exp 3,2(0.08);Exp 4,2(0.08);Hill,3(0.12);Linear,3(0.12);Poly 2,7(0.27) 1.9027713023627901 50.926947712898254 1.522104263305664 4.21828556060791 0.5668128043313648 1.7831463813781738 30.539592777988474 56.968147298934696 20.896194750373287 40.646341480396046 49.71237425328504 95.78214882363812 DOWN 0.3076923076923077 0.6923076923076923 0.0 GO:0032502 2 developmental process 992 1073 97 97 69 85 60 60 102 1013 1372 0.10085 0.92552 0.18866 5.59 79426;24522;308843;24825;362895;29573;29482;293615;246074;297784;25106;83516;303612;85253;363465;25513;81819;294103;24314;25493;307582;24516;25685;494344;65164;24471;29540;24464;25675;29328;290556;24957;294515;314322;25661;246186;361969;80841;24890;29496;25315;116636;24330;116663;140942;25146;25423;497840;113936;25695;114851;29184;79431;25698;155423;65183;25373;50681;24158;312382 zfp36;zfp354a;tsku;tf;stac3;slc37a4;slc1a2;sirt3;scd;rrs1;rgn;ppargc1a;polg2;plg;pir;pik3r1;pax8;papss2;nqo1;nfkbia;lama3;jun;igfbp1;ier2;htra1;hspb1;hsd17b7;hp;hmgcr;gpx4;gnl3;glul;foxo3;fos;fn1;fgl1;fga;fabp7;esr1;erbb3;ephx1;eif4ebp1;egr1;dusp6;ddit4;cyp17a1;ctsc;cps1;cpb2;cebpd;cdkn1a;cd36;bhlhe40;ass1;anxa7;aldh3a2;ahsg;acox1;acadm;abcg2 ZFP36_10204;ZFP354A_10203;TSKU_10094;TF_10003;STAC3_9953;SLC37A4_9871;SLC1A2_33059;SIRT3_9828;SCD1_9787;RRS1_9755;RGN_9699;PPARGC1A_33189;POLG2_9521;PLG_9501;PIR_9487;PIK3R1_32562;PAX8_9432;PAPSS2_33237;NQO1_33055;NFKBIA_9307;LAMA3_8980;JUN_8938;IGFBP1_32306;IER2_32643;HTRA1_8856;HSPB1_8847;HSD17B7_8834;HP_8823;HMGCR_8810;GPX4_32827;GNL3_8735;GLUL_32832;FOXO3_8662;FOS_8657;FN1_8655;FGL1_8640;FGA_8632;FABP7_8592;ESR1_33192;ERBB3_8571;EPHX1_8567;EIF4EBP1_8550;EGR1_8533;DUSP6_8506;DDIT4_8450;CYP17A1_32365;CTSC_32456;CPS1_32421;CPB2_8369;CEBPD_8283;CDKN1A_8271;CD36_8243;BHLHE40_8141;ASS1_33159;ANXA7_8051;ALDH3A2_8024;AHSG_8003;ACOX1_7973;ACADM_7957;ABCG2_32656 37.96909215000002 33.7883 1.28141E-12 29.841367339047707 39.00285339080376 28.196789376831845 24.97728825333336 25.04905 1.28141E-12 18.936137155884353 25.69091595861024 17.928398361915416 70.83753766666669 48.882149999999996 1.28142E-12 72.73143495757041 68.21739888494038 62.14818716162295 52.5 80.6704 0.348134;0.834827;1.38416;45.1539;63.2393;39.7166;13.3235;2.38018;105.46;60.39;77.4407;42.4094;63.7758;70.7857;50.0307;18.7324;56.8931;34.4443;87.2765;0.520151;2.46923;16.4324;49.0259;49.6814;33.1323;89.1011;0.977494;64.9285;1.63089;45.9204;87.6357;26.4669;13.1992;1.28141E-12;59.5777;15.4757;28.5803;24.601;23.3972;60.9984;12.4747;83.9001;0.750017;62.3934;87.5421;49.6922;56.2386;31.9826;25.8316;0.306936;6.24967;48.1296;57.8085;26.8037;104.64;43.1079;12.402;23.1906;11.7137;5.21654 0.118102;0.27095;0.540568;28.132;42.7031;22.6911;9.10952;0.56209;63.7532;43.109;58.7732;26.2988;40.9553;46.2356;38.7717;11.6701;45.1162;25.719;60.6992;0.160202;0.871501;10.5224;32.6883;33.4626;25.6145;60.3265;0.322682;41.6103;0.663137;34.2198;54.41;21.0456;5.6804;1.28141E-12;31.0499;10.2138;22.529;14.4402;18.3088;41.6036;7.00435;42.4185;0.186019;39.0875;53.2453;35.6654;38.2681;24.4836;20.4374;0.0732342;2.44025;37.5433;38.3491;20.9825;43.9254;31.8774;10.3013;16.2815;8.36151;2.73368 1.15962;2.99857;4.10872;61.5341;121.52;60.0334;24.6773;8.82917;422.699;104.942;89.8047;81.7305;132.567;150.579;73.0083;41.5978;81.5688;51.1014;197.117;2.88499;10.4175;39.929;89.1623;89.4404;46.6629;106.138;5.49472;136.455;7.6286;70.4292;238.963;35.4303;32.7581;1.28142E-12;105.243;30.4106;38.8511;35.6155;31.9156;113.972;23.684;107.32;4.70178;133.304;245.492;81.6409;102.888;45.5891;34.8042;1.73689;19.0606;69.1421;110.58;36.7081;108.689;66.3058;15.4235;33.4539;18.9642;11.386 21 39 21 24825;293615;246074;297784;25106;363465;81819;24314;29328;290556;80841;29496;25315;116636;25146;29184;155423;65183;50681;24158;312382 TF_10003;SIRT3_9828;SCD1_9787;RRS1_9755;RGN_9699;PIR_9487;PAX8_9432;NQO1_33055;GPX4_32827;GNL3_8735;FABP7_8592;ERBB3_8571;EPHX1_8567;EIF4EBP1_8550;CYP17A1_32365;CD36_8243;ANXA7_8051;ALDH3A2_8024;ACOX1_7973;ACADM_7957;ABCG2_32656 51.72599619047618 49.6922 31.29350995045436 33.78101095238095 37.5433 19.12655953198402 96.14612714285715 73.0083 93.80670647473437 45.1539;2.38018;105.46;60.39;77.4407;50.0307;56.8931;87.2765;45.9204;87.6357;24.601;60.9984;12.4747;83.9001;49.6922;48.1296;104.64;43.1079;23.1906;11.7137;5.21654 28.132;0.56209;63.7532;43.109;58.7732;38.7717;45.1162;60.6992;34.2198;54.41;14.4402;41.6036;7.00435;42.4185;35.6654;37.5433;43.9254;31.8774;16.2815;8.36151;2.73368 61.5341;8.82917;422.699;104.942;89.8047;73.0083;81.5688;197.117;70.4292;238.963;35.6155;113.972;23.684;107.32;81.6409;69.1421;108.689;66.3058;33.4539;18.9642;11.386 39 79426;24522;308843;362895;29573;29482;83516;303612;85253;25513;294103;25493;307582;24516;25685;494344;65164;24471;29540;24464;25675;24957;294515;314322;25661;246186;361969;24890;24330;116663;140942;25423;497840;113936;25695;114851;79431;25698;25373 ZFP36_10204;ZFP354A_10203;TSKU_10094;STAC3_9953;SLC37A4_9871;SLC1A2_33059;PPARGC1A_33189;POLG2_9521;PLG_9501;PIK3R1_32562;PAPSS2_33237;NFKBIA_9307;LAMA3_8980;JUN_8938;IGFBP1_32306;IER2_32643;HTRA1_8856;HSPB1_8847;HSD17B7_8834;HP_8823;HMGCR_8810;GLUL_32832;FOXO3_8662;FOS_8657;FN1_8655;FGL1_8640;FGA_8632;ESR1_33192;EGR1_8533;DUSP6_8506;DDIT4_8450;CTSC_32456;CPS1_32421;CPB2_8369;CEBPD_8283;CDKN1A_8271;BHLHE40_8141;ASS1_33159;AHSG_8003 30.561528435897472 26.4669 26.57657317395093 20.23682218461542 20.9825 17.271462329668932 57.20983564102567 38.8511 55.11089243546359 0.348134;0.834827;1.38416;63.2393;39.7166;13.3235;42.4094;63.7758;70.7857;18.7324;34.4443;0.520151;2.46923;16.4324;49.0259;49.6814;33.1323;89.1011;0.977494;64.9285;1.63089;26.4669;13.1992;1.28141E-12;59.5777;15.4757;28.5803;23.3972;0.750017;62.3934;87.5421;56.2386;31.9826;25.8316;0.306936;6.24967;57.8085;26.8037;12.402 0.118102;0.27095;0.540568;42.7031;22.6911;9.10952;26.2988;40.9553;46.2356;11.6701;25.719;0.160202;0.871501;10.5224;32.6883;33.4626;25.6145;60.3265;0.322682;41.6103;0.663137;21.0456;5.6804;1.28141E-12;31.0499;10.2138;22.529;18.3088;0.186019;39.0875;53.2453;38.2681;24.4836;20.4374;0.0732342;2.44025;38.3491;20.9825;10.3013 1.15962;2.99857;4.10872;121.52;60.0334;24.6773;81.7305;132.567;150.579;41.5978;51.1014;2.88499;10.4175;39.929;89.1623;89.4404;46.6629;106.138;5.49472;136.455;7.6286;35.4303;32.7581;1.28142E-12;105.243;30.4106;38.8511;31.9156;4.70178;133.304;245.492;102.888;45.5891;34.8042;1.73689;19.0606;110.58;36.7081;15.4235 0 Exp 2,22(0.37);Exp 3,2(0.04);Exp 4,7(0.12);Hill,9(0.15);Linear,9(0.15);Poly 2,9(0.15);Power,2(0.04) 1.9365252147476064 122.56266462802887 1.5074360370635986 5.973292827606201 0.834891342150754 1.7549105286598206 30.418184392830295 45.51999990716975 20.185784455379043 29.768792051287683 52.43394542601939 89.24112990731396 DOWN 0.35 0.65 0.0 GO:0070980 6 biphenyl catabolic process 1 2 1 1 1 1 1 1 161 1 2384 0.99598 0.12319 0.12319 50.0 286954 ugt2b1 UGT2B10_33303,UGT2B1_33224 47.47345 47.47345 47.47345 47.47345 34.82915 34.82915 34.82915 34.82915 76.47475 76.47475 76.47475 76.47475 0.0 47.47345 0.0 47.47345 47.47345 34.82915 76.47475 2 0 1 286954 UGT2B10_33303,UGT2B1_33224 47.47345 47.47345 34.82915 34.82915 76.47475 76.47475 47.47345 34.82915 76.47475 0 0 Exp 2,2(1) 1.7062456471598688 3.415005087852478 1.6419988870620728 1.7730062007904053 0.09263615992233741 1.707502543926239 47.47345 47.47345 34.82915 34.82915 76.47475 76.47475 UP 1.0 0.0 0.0 GO:0050714 7 positive regulation of protein secretion 92 99 12 12 9 11 8 8 154 91 2294 0.82559 0.29209 0.40572 8.08 293615;100359982;24539;63868;24957;361969;65210;29184 sirt3;mpc2;lpl;hspd1;glul;fga;cyp2j4;cd36 SIRT3_9828;MPC2_33219;LPL_32544;HSPD1_8849;GLUL_32832;FGA_8632;CYP2J4_32580;CD36_8243 35.8380975 35.4191 2.38018 21.939209161734514 38.22501066443657 22.388040052108412 25.749323750000002 23.237949999999998 0.56209 15.194751692511597 27.485964846619 15.241630204913054 62.72532125 53.98905 8.82917 47.92368353104056 67.24469979285755 50.290030697812306 3.5 35.4191 2.38018;46.8463;74.2041;42.2579;26.4669;28.5803;17.8395;48.1296 0.56209;35.8494;49.8682;23.9469;21.0456;22.529;14.6501;37.5433 8.82917;69.127;155.425;102.383;35.4303;38.8511;22.6149;69.1421 6 2 6 293615;100359982;24539;63868;65210;29184 SIRT3_9828;MPC2_33219;LPL_32544;HSPD1_8849;CYP2J4_32580;CD36_8243 38.60959666666667 44.552099999999996 25.229823929533616 27.06999833333333 29.89815 17.738110173736573 71.25352833333334 69.13454999999999 53.526400179003424 2.38018;46.8463;74.2041;42.2579;17.8395;48.1296 0.56209;35.8494;49.8682;23.9469;14.6501;37.5433 8.82917;69.127;155.425;102.383;22.6149;69.1421 2 24957;361969 GLUL_32832;FGA_8632 27.523600000000002 27.523600000000002 1.4943994713595314 21.787300000000002 21.787300000000002 1.0489221992120368 37.1407 37.1407 2.418870877082957 26.4669;28.5803 21.0456;22.529 35.4303;38.8511 0 Exp 2,3(0.38);Exp 3,1(0.13);Hill,1(0.13);Linear,3(0.38) 2.101416816745975 17.637054324150085 1.5209722518920898 3.8079800605773926 0.7761867858851107 2.0871151089668274 20.635001199310135 51.04119380068984 15.2198980289837 36.278749471016305 29.5159028778479 95.93473962215211 UP 0.75 0.25 0.0 GO:0055096 6 low-density lipoprotein particle mediated signaling 2 2 2 2 2 2 2 2 160 0 2385 1.0 0.0040221 0.0040221 100.0 24539;29184 lpl;cd36 LPL_32544;CD36_8243 61.16685 61.16685 48.1296 18.437455766048654 61.14777896928097 18.437436039660607 43.70575 43.70575 37.5433 8.715020367446073 43.69673550129402 8.715011043172915 112.28355 112.28355 69.1421 61.01122369044077 112.22044221897154 61.011158414022496 0.0 48.1296 0.0 48.1296 74.2041;48.1296 49.8682;37.5433 155.425;69.1421 2 0 2 24539;29184 LPL_32544;CD36_8243 61.16685 61.16685 18.437455766048654 43.70575 43.70575 8.715020367446073 112.28355 112.28355 61.01122369044077 74.2041;48.1296 49.8682;37.5433 155.425;69.1421 0 0 Exp 2,2(1) 2.0406078096090083 4.22970986366272 1.559399127960205 2.6703107357025146 0.785533131133437 2.11485493183136 35.61384000000001 86.71985999999998 31.627348 55.784152000000006 27.726308000000003 196.84079200000002 UP 1.0 0.0 0.0 GO:0042592 4 homeostatic process 357 379 44 44 35 38 30 30 132 349 2036 0.92454 0.11111 0.1726 7.92 24825;29573;246074;25106;83516;85253;25513;360722;25591;24314;24567;24539;288001;81678;25675;81869;294515;25661;304929;24890;65030;24330;25428;497840;113936;29184;155423;50681;25287;25303 tf;slc37a4;scd;rgn;ppargc1a;plg;pik3r1;pdia5;parp1;nqo1;mt1;lpl;kng1;itpr2;hmgcr;gstm7;foxo3;fn1;f5;esr1;ephx2;egr1;cyp7a1;cps1;cpb2;cd36;anxa7;acox1;acadl;abcc2 TF_10003;SLC37A4_9871;SCD1_9787;RGN_9699;PPARGC1A_33189;PLG_9501;PIK3R1_32562;PDIA5_9451;PARP1_9425;NQO1_33055;MT1A_9255;LPL_32544;KNG1L1_34113;ITPR2_8931;HMGCR_8810;GSTM7_8761;FOXO3_8662;FN1_8655;F5_33079;ESR1_33192;EPHX2_33282;EGR1_8533;CYP7A1_8430;CPS1_32421;CPB2_8369;CD36_8243;ANXA7_8051;ACOX1_7973;ACADL_32776;ABCC2_32541 42.458366233333344 36.10855 0.750017 30.717731982108532 46.71765219876189 26.804953863966066 27.499031633333335 25.5165 0.186019 18.631010110995646 30.31794204611832 15.844898776358047 76.42375933333332 51.4002 4.70178 79.48196641488079 82.08573232418762 72.55285876040642 17.5 42.3623 45.1539;39.7166;105.46;77.4407;42.4094;70.7857;18.7324;107.066;26.9741;87.2765;12.9315;74.2041;24.3655;31.8111;1.63089;42.3152;13.1992;59.5777;10.6089;23.3972;38.7293;0.750017;5.72128;31.9826;25.8316;48.1296;104.64;23.1906;33.4878;46.2316 28.132;22.6911;63.7532;58.7732;26.2988;46.2356;11.6701;61.3361;21.799;60.6992;8.91033;49.8682;19.538;24.7342;0.663137;31.4035;5.6804;31.0499;2.59129;18.3088;29.2097;0.186019;0.985273;24.4836;20.4374;37.5433;43.9254;16.2815;26.6039;31.1788 61.5341;60.0334;422.699;89.8047;81.7305;150.579;41.5978;114.259;35.2797;197.117;23.4636;155.425;32.1467;44.3296;7.6286;64.5991;32.7581;105.243;37.5078;31.9156;57.2113;4.70178;22.3625;45.5891;34.8042;69.1421;108.689;33.4539;45.3228;81.7848 12 18 12 24825;246074;25106;25591;24314;24539;81869;65030;29184;155423;50681;25287 TF_10003;SCD1_9787;RGN_9699;PARP1_9425;NQO1_33055;LPL_32544;GSTM7_8761;EPHX2_33282;CD36_8243;ANXA7_8051;ACOX1_7973;ACADL_32776 58.91681666666667 46.64175 29.496148209025325 38.99934166666666 34.4734 16.114344496326513 111.68980833333335 66.8706 109.66914674788859 45.1539;105.46;77.4407;26.9741;87.2765;74.2041;42.3152;38.7293;48.1296;104.64;23.1906;33.4878 28.132;63.7532;58.7732;21.799;60.6992;49.8682;31.4035;29.2097;37.5433;43.9254;16.2815;26.6039 61.5341;422.699;89.8047;35.2797;197.117;155.425;64.5991;57.2113;69.1421;108.689;33.4539;45.3228 18 29573;83516;85253;25513;360722;24567;288001;81678;25675;294515;25661;304929;24890;24330;25428;497840;113936;25303 SLC37A4_9871;PPARGC1A_33189;PLG_9501;PIK3R1_32562;PDIA5_9451;MT1A_9255;KNG1L1_34113;ITPR2_8931;HMGCR_8810;FOXO3_8662;FN1_8655;F5_33079;ESR1_33192;EGR1_8533;CYP7A1_8430;CPS1_32421;CPB2_8369;ABCC2_32541 31.486065944444444 25.098550000000003 26.98139938967597 19.832158277777776 19.9877 16.38648276092529 52.91306 39.552800000000005 39.130011873086104 39.7166;42.4094;70.7857;18.7324;107.066;12.9315;24.3655;31.8111;1.63089;13.1992;59.5777;10.6089;23.3972;0.750017;5.72128;31.9826;25.8316;46.2316 22.6911;26.2988;46.2356;11.6701;61.3361;8.91033;19.538;24.7342;0.663137;5.6804;31.0499;2.59129;18.3088;0.186019;0.985273;24.4836;20.4374;31.1788 60.0334;81.7305;150.579;41.5978;114.259;23.4636;32.1467;44.3296;7.6286;32.7581;105.243;37.5078;31.9156;4.70178;22.3625;45.5891;34.8042;81.7848 0 Exp 2,11(0.37);Exp 3,2(0.07);Exp 4,2(0.07);Hill,3(0.1);Linear,5(0.17);Poly 2,5(0.17);Power,2(0.07) 2.0951530608746656 67.88303482532501 1.5254690647125244 5.973292827606201 1.0970074606633824 1.8304733633995056 31.466167014960817 53.45056545170583 20.832010288825895 34.16605297784078 47.98150293207185 104.86601573459482 DOWN 0.4 0.6 0.0 GO:0050878 4 regulation of body fluid levels 107 110 17 16 14 14 12 12 150 98 2287 0.97981 0.043607 0.067598 10.91 79224;246074;85253;294103;288001;24384;361969;304929;113936;81718;29184;155423 serpind1;scd;plg;papss2;kng1;gc;fga;f5;cpb2;cdo1;cd36;anxa7 SERPIND1_9812;SCD1_9787;PLG_9501;PAPSS2_33237;KNG1L1_34113;GC_32893;FGA_8632;F5_33079;CPB2_8369;CDO1_8275;CD36_8243;ANXA7_8051 45.535558333333334 31.5123 10.6089 31.641977690675365 48.98422200139353 29.12958318473071 29.122149166666663 24.124000000000002 2.59129 16.16669705527411 31.710206976840638 14.247883543122018 91.05190833333334 44.97625 30.0179 110.70115556205167 92.7311464713494 98.49651378829003 4.5 28.420650000000002 10.0 104.64 28.261;105.46;70.7857;34.4443;24.3655;42.356;28.5803;10.6089;25.8316;22.9638;48.1296;104.64 22.307;63.7532;46.2356;25.719;19.538;26.3722;22.529;2.59129;20.4374;18.5144;37.5433;43.9254 38.3264;422.699;150.579;51.1014;32.1467;78.7583;38.8511;37.5078;34.8042;30.0179;69.1421;108.689 3 9 3 246074;29184;155423 SCD1_9787;CD36_8243;ANXA7_8051 86.07653333333333 104.64 32.86556574978335 48.4073 43.9254 13.667672999088012 200.17669999999998 108.689 193.7217587749761 105.46;48.1296;104.64 63.7532;37.5433;43.9254 422.699;69.1421;108.689 9 79224;85253;294103;288001;24384;361969;304929;113936;81718 SERPIND1_9812;PLG_9501;PAPSS2_33237;KNG1L1_34113;GC_32893;FGA_8632;F5_33079;CPB2_8369;CDO1_8275 32.021899999999995 28.261 16.877458465509566 22.693765555555554 22.307 11.256688508223798 54.676977777777786 38.3264 38.911894067873945 28.261;70.7857;34.4443;24.3655;42.356;28.5803;10.6089;25.8316;22.9638 22.307;46.2356;25.719;19.538;26.3722;22.529;2.59129;20.4374;18.5144 38.3264;150.579;51.1014;32.1467;78.7583;38.8511;37.5078;34.8042;30.0179 0 Exp 2,4(0.34);Exp 3,2(0.17);Hill,1(0.09);Linear,5(0.42) 1.805788560038205 22.085700035095215 1.5254690647125244 2.6703107357025146 0.3937668000416111 1.6386691331863403 27.63242408267785 63.43869258398882 19.974979207832426 38.26931912550091 28.416833209247223 153.68698345741944 DOWN 0.25 0.75 0.0 GO:0008654 5 phospholipid biosynthetic process 31 34 9 9 4 8 4 4 158 30 2355 0.93913 0.16664 0.27209 11.76 25513;25675;298541;362866 pik3r1;hmgcr;dhdds;chpt1 PIK3R1_32562;HMGCR_8810;DHDDS_8467;CHPT1_33298 21.0907475 17.39415 1.63089 19.413774961498135 21.39243983101464 15.404106480325389 14.87603425 11.136099999999999 0.663137 15.287544630756075 14.832668975307744 12.378803469524934 37.626400000000004 35.751400000000004 7.6286 26.54665104804496 38.50174499235196 20.545549820161526 0.5 8.843395000000001 2.5 33.3381 18.7324;1.63089;47.9438;16.0559 11.6701;0.663137;36.5688;10.6021 41.5978;7.6286;71.3742;29.905 2 2 2 298541;362866 DHDDS_8467;CHPT1_33298 31.999850000000002 31.999850000000002 22.548150327798517 23.58545 23.58545 18.361229655036723 50.6396 50.6396 29.323152530381194 47.9438;16.0559 36.5688;10.6021 71.3742;29.905 2 25513;25675 PIK3R1_32562;HMGCR_8810 10.181645 10.181645 12.092593689529552 6.1666185 6.1666185 7.783098177569424 24.6132 24.6132 24.01985167148207 18.7324;1.63089 11.6701;0.663137 41.5978;7.6286 0 Exp 2,1(0.25);Exp 4,1(0.25);Poly 2,2(0.5) 1.7259994472041051 6.918844699859619 1.5922520160675049 1.9017701148986816 0.13179984960075994 1.7124112844467163 2.0652480377318305 40.116246962268164 -0.10575948814095426 29.857827988140958 11.610681972915938 63.64211802708407 CONFLICT 0.5 0.5 0.0 GO:0009062 6 fatty acid catabolic process 37 42 24 24 15 23 14 14 148 28 2357 1.0 1.1315E-7 1.1315E-7 33.33 65192;171155;113965;85255;295143;171142;291075;29740;83842;50681;192272;24158;25287;170465 slc27a2;hadhb;hadh;hacl1;etfdh;ehhadh;eci2;eci1;crot;acox1;acot2;acadm;acadl;acaa2 SLC27A2_9860;HADHB_8777;HADH_8776;HACL1_8775;ETFDH_8575;EHHADH_8534;ECI2_8521;ECI1_8520;CROT_8384;ACOX1_7973;ACOT2_7969;ACADM_7957;ACADL_32776;ACAA2_7955 17.90437357142857 14.787400000000002 7.4229 9.971227854987113 17.577026811294324 9.944237077819519 13.702707857142856 10.059295 5.49916 8.004846742293243 13.509654861049212 7.849403491135787 25.653592857142858 21.005650000000003 10.316 13.901920475933377 25.376818781435027 13.957775025219652 1.5 8.085469999999999 3.5 9.637395 7.62189;31.8029;33.3125;17.6275;18.1231;8.62809;10.6467;11.9473;7.4229;23.1906;8.54905;11.7137;33.4878;26.5872 5.49916;25.5756;25.7336;11.195;14.869;7.31865;8.92359;7.15307;5.75707;16.2815;7.19676;8.36151;26.6039;21.3695 13.3925;42.1484;46.9856;37.6534;23.0103;10.3909;13.0581;19.001;10.316;33.4539;10.4125;18.9642;45.3228;35.0407 14 0 14 65192;171155;113965;85255;295143;171142;291075;29740;83842;50681;192272;24158;25287;170465 SLC27A2_9860;HADHB_8777;HADH_8776;HACL1_8775;ETFDH_8575;EHHADH_8534;ECI2_8521;ECI1_8520;CROT_8384;ACOX1_7973;ACOT2_7969;ACADM_7957;ACADL_32776;ACAA2_7955 17.90437357142857 14.787400000000002 9.971227854987113 13.702707857142856 10.059295 8.004846742293243 25.653592857142858 21.005650000000003 13.901920475933377 7.62189;31.8029;33.3125;17.6275;18.1231;8.62809;10.6467;11.9473;7.4229;23.1906;8.54905;11.7137;33.4878;26.5872 5.49916;25.5756;25.7336;11.195;14.869;7.31865;8.92359;7.15307;5.75707;16.2815;7.19676;8.36151;26.6039;21.3695 13.3925;42.1484;46.9856;37.6534;23.0103;10.3909;13.0581;19.001;10.316;33.4539;10.4125;18.9642;45.3228;35.0407 0 0 Exp 2,4(0.29);Hill,2(0.15);Linear,4(0.29);Poly 2,3(0.22);Power,1(0.08) 3.7757469956641403 87.99135327339172 1.693061113357544 32.73371124267578 8.456062714774394 2.413228988647461 12.681125001193966 23.127622141663178 9.50951270508158 17.895903009204137 18.371321575666055 32.935864138619664 UP 1.0 0.0 0.0 GO:0014911 8 positive regulation of smooth muscle cell migration 32 35 3 3 3 2 2 2 160 33 2352 0.61347 0.66341 1.0 5.71 361969;24330 fga;egr1 FGA_8632;EGR1_8533 14.6651585 14.6651585 0.750017 19.678981831640694 17.221623665268996 19.34402485646606 11.3575095 11.3575095 0.186019 15.798873377022186 13.409915960069666 15.529959930035531 21.77644 21.77644 4.70178 24.147215744909396 24.913366311443685 23.736204727469485 0.5 14.6651585 28.5803;0.750017 22.529;0.186019 38.8511;4.70178 0 2 0 2 361969;24330 FGA_8632;EGR1_8533 14.6651585 14.6651585 19.678981831640694 11.3575095 11.3575095 15.798873377022186 21.77644 21.77644 24.147215744909396 28.5803;0.750017 22.529;0.186019 38.8511;4.70178 0 Hill,1(0.5);Linear,1(0.5) 2.5503248948263466 5.760181427001953 1.541895866394043 4.21828556060791 1.8924933018764158 2.8800907135009766 -12.608518839999999 41.938835839999996 -10.538611879999996 33.253630879999996 -11.689893600000005 55.24277360000001 DOWN 0.0 1.0 0.0 GO:0046034 3 ATP metabolic process 31 37 4 4 4 3 3 3 159 34 2351 0.79406 0.42166 0.508 8.11 24651;25591;361239 pklr;parp1;bphl PKLR_9489;PARP1_9425;BPHL_8157 20.7952 23.0963 12.3152 7.595533767287192 20.683393001555213 8.0287222043138 15.289266666666668 17.4625 6.6063 7.826029687097622 15.205795692068431 8.289542278193025 31.24303333333333 32.9443 25.5051 5.104550175415426 31.142928087091757 5.381163864524702 0.5 17.705750000000002 23.0963;26.9741;12.3152 17.4625;21.799;6.6063 32.9443;35.2797;25.5051 2 1 2 25591;361239 PARP1_9425;BPHL_8157 19.64465 19.64465 10.365407594735487 14.20265 14.20265 10.74286119453286 30.3924 30.3924 6.911685943386034 26.9741;12.3152 21.799;6.6063 35.2797;25.5051 1 24651 PKLR_9489 23.0963 23.0963 17.4625 17.4625 32.9443 32.9443 23.0963 17.4625 32.9443 0 Exp 2,2(0.67);Exp 4,1(0.34) 2.006598726454953 6.161889672279358 1.6564509868621826 2.6967689990997314 0.5618648248487809 1.8086696863174438 12.200044408242979 29.39035559175702 6.433280387464308 24.145252945869025 25.466691034311992 37.01937563235467 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0042113 5 B cell activation 34 36 2 2 2 2 2 2 160 34 2351 0.59583 0.67866 1.0 5.56 25513;63868 pik3r1;hspd1 PIK3R1_32562;HSPD1_8849 30.49515 30.49515 18.7324 16.635040580804123 34.0956332764323 15.836591030814127 17.8085 17.8085 11.6701 8.681008531271006 19.68741492585085 8.264337028632704 71.9904 71.9904 41.5978 42.98162711578053 81.29333069454816 40.918592723905675 0.5 30.49515 18.7324;42.2579 11.6701;23.9469 41.5978;102.383 1 1 1 63868 HSPD1_8849 42.2579 42.2579 23.9469 23.9469 102.383 102.383 42.2579 23.9469 102.383 1 25513 PIK3R1_32562 18.7324 18.7324 11.6701 11.6701 41.5978 41.5978 18.7324 11.6701 41.5978 0 Exp 3,1(0.5);Poly 2,1(0.5) 1.9413016893779504 3.925430655479431 1.6735800504684448 2.2518506050109863 0.4088990304775364 1.9627153277397156 7.440160000000002 53.55014 5.777236000000002 29.839763999999995 12.420904 131.55989599999998 CONFLICT 0.5 0.5 0.0 GO:0001666 4 response to hypoxia 168 175 21 21 19 18 16 16 146 159 2226 0.9516 0.085045 0.14553 9.14 24522;24825;24648;83516;24651;81678;192235;63868;24464;294515;24360;116636;24330;140942;192272;170465 zfp354a;tf;serpina1;ppargc1a;pklr;itpr2;hyou1;hspd1;hp;foxo3;fabp1;eif4ebp1;egr1;ddit4;acot2;acaa2 ZFP354A_10203;TF_10003;SERPINA1_9807;PPARGC1A_33189;PKLR_9489;ITPR2_8931;HYOU1_8857;HSPD1_8849;HP_8823;FOXO3_8662;FABP1_33091;EIF4EBP1_8550;EGR1_8533;DDIT4_8450;ACOT2_7969;ACAA2_7955 35.053912125 32.82945 0.750017 26.322655770719855 35.17881663570194 25.551949438419072 22.5889455625 24.34055 0.186019 15.164227973664524 22.624885572620542 14.612149135642023 64.206021875 45.62765 2.99857 61.84482382842056 60.63956703718607 51.36951749264521 7.5 32.82945 0.834827;45.1539;15.797;42.4094;23.0963;31.8111;40.1982;42.2579;64.9285;13.1992;33.8478;83.9001;0.750017;87.5421;8.54905;26.5872 0.27095;28.132;13.013;26.2988;17.4625;24.7342;29.3844;23.9469;41.6103;5.6804;26.4736;42.4185;0.186019;53.2453;7.19676;21.3695 2.99857;61.5341;19.9134;81.7305;32.9443;44.3296;62.3571;102.383;136.455;32.7581;46.9257;107.32;4.70178;245.492;10.4125;35.0407 6 10 6 24825;63868;24360;116636;192272;170465 TF_10003;HSPD1_8849;FABP1_33091;EIF4EBP1_8550;ACOT2_7969;ACAA2_7955 40.049325 38.05285 25.162591299302818 24.922876666666667 25.210250000000002 11.371844876855578 60.602666666666664 54.2299 38.17983615044291 45.1539;42.2579;33.8478;83.9001;8.54905;26.5872 28.132;23.9469;26.4736;42.4185;7.19676;21.3695 61.5341;102.383;46.9257;107.32;10.4125;35.0407 10 24522;24648;83516;24651;81678;192235;24464;294515;24330;140942 ZFP354A_10203;SERPINA1_9807;PPARGC1A_33189;PKLR_9489;ITPR2_8931;HYOU1_8857;HP_8823;FOXO3_8662;EGR1_8533;DDIT4_8450 32.0566644 27.453699999999998 27.864539910626245 21.1885869 21.09835 17.481480425525703 66.36803499999999 38.63695 74.50472472197917 0.834827;15.797;42.4094;23.0963;31.8111;40.1982;64.9285;13.1992;0.750017;87.5421 0.27095;13.013;26.2988;17.4625;24.7342;29.3844;41.6103;5.6804;0.186019;53.2453 2.99857;19.9134;81.7305;32.9443;44.3296;62.3571;136.455;32.7581;4.70178;245.492 0 Exp 2,7(0.44);Exp 3,2(0.13);Exp 4,1(0.07);Hill,2(0.13);Linear,3(0.19);Poly 2,1(0.07) 2.3734232446229173 45.88033330440521 1.6336230039596558 11.836054801940918 2.560737916035143 1.8549068570137024 22.15581079734728 47.95201345265273 15.158473855404388 30.01941726959562 33.90205819907392 94.50998555092609 DOWN 0.375 0.625 0.0 GO:0050709 7 negative regulation of protein secretion 32 34 7 7 5 6 4 4 158 30 2355 0.93913 0.16664 0.27209 11.76 25591;25675;113965;25661 parp1;hmgcr;hadh;fn1 PARP1_9425;HMGCR_8810;HADH_8776;FN1_8655 30.373797500000002 30.1433 1.63089 23.799275677059825 40.117805025874716 19.112364295138867 19.811409249999997 23.7663 0.663137 13.316441776576143 25.508029364408745 7.54934900842092 48.784225 41.13265 7.6286 41.097388363931756 64.1268859851703 38.58086799904298 0.5 14.302495 2.5 46.4451 26.9741;1.63089;33.3125;59.5777 21.799;0.663137;25.7336;31.0499 35.2797;7.6286;46.9856;105.243 2 2 2 25591;113965 PARP1_9425;HADH_8776 30.1433 30.1433 4.481925621872816 23.7663 23.7663 2.7821823412565525 41.13265 41.13265 8.27732126989163 26.9741;33.3125 21.799;25.7336 35.2797;46.9856 2 25675;25661 HMGCR_8810;FN1_8655 30.604295 30.604295 40.97458229912844 15.8565185 15.8565185 21.48668617560848 56.4358 56.4358 69.02380418145611 1.63089;59.5777 0.663137;31.0499 7.6286;105.243 0 Exp 2,1(0.25);Exp 4,1(0.25);Linear,1(0.25);Power,1(0.25) 1.8620080059014699 7.4538291692733765 1.7792335748672485 1.9641557931900024 0.0850556225938134 1.8552199006080627 7.050507336481367 53.69708766351863 6.761296308955384 32.861522191044614 8.508784403346873 89.05966559665313 CONFLICT 0.5 0.5 0.0 GO:0048468 4 cell development 159 163 8 8 4 5 2 2 160 161 2224 0.0012721 0.9998 0.0023988 1.23 362895;24890 stac3;esr1 STAC3_9953;ESR1_33192 43.31825 43.31825 23.3972 28.172619086712544 53.56795608270783 24.15747330829953 30.50595 30.50595 18.3088 17.24937495229899 36.78158318934995 14.791003765480514 76.7178 76.7178 31.9156 63.35987886415189 99.7692647500354 54.32986467345331 63.2393;23.3972 42.7031;18.3088 121.52;31.9156 0 2 0 2 362895;24890 STAC3_9953;ESR1_33192 43.31825 43.31825 28.172619086712544 30.50595 30.50595 17.24937495229899 76.7178 76.7178 63.35987886415189 63.2393;23.3972 42.7031;18.3088 121.52;31.9156 0 Exp 2,1(0.5);Linear,1(0.5) 2.6488584248025058 5.316137075424194 2.436986207962036 2.879150867462158 0.3126576291335771 2.658068537712097 4.272992000000002 82.363508 6.5995360000000005 54.412364 -11.094511999999995 164.53011199999997 DOWN 0.0 1.0 0.0 GO:0019878 10 lysine biosynthetic process via aminoadipic acid 1 1 1 1 1 1 1 1 161 0 2385 1.0 0.063604 0.063604 100.0 296925 aass AASS_7936 27.4644 27.4644 27.4644 27.4644 21.7498 21.7498 21.7498 21.7498 37.0295 37.0295 37.0295 37.0295 0.0 27.4644 0.0 27.4644 27.4644 21.7498 37.0295 1 0 1 296925 AASS_7936 27.4644 27.4644 21.7498 21.7498 37.0295 37.0295 27.4644 21.7498 37.0295 0 0 Linear,1(1) 1.9288111925125122 1.9288111925125122 1.9288111925125122 1.9288111925125122 0.0 1.9288111925125122 27.4644 27.4644 21.7498 21.7498 37.0295 37.0295 UP 1.0 0.0 0.0 GO:0033512 10 L-lysine catabolic process to acetyl-CoA via saccharopine 1 1 1 1 1 1 1 1 161 0 2385 1.0 0.063604 0.063604 100.0 296925 aass AASS_7936 27.4644 27.4644 27.4644 27.4644 21.7498 21.7498 21.7498 21.7498 37.0295 37.0295 37.0295 37.0295 0.0 27.4644 0.0 27.4644 27.4644 21.7498 37.0295 1 0 1 296925 AASS_7936 27.4644 27.4644 21.7498 21.7498 37.0295 37.0295 27.4644 21.7498 37.0295 0 0 Linear,1(1) 1.9288111925125122 1.9288111925125122 1.9288111925125122 1.9288111925125122 0.0 1.9288111925125122 27.4644 27.4644 21.7498 21.7498 37.0295 37.0295 UP 1.0 0.0 0.0 GO:0018879 6 biphenyl metabolic process 5 7 2 2 2 2 2 2 160 5 2380 0.99269 0.068343 0.068343 28.57 286954;25146 ugt2b1;cyp17a1 UGT2B10_33303,UGT2B1_33224;CYP17A1_32365 48.582825 48.582825 47.47345 1.5688931707576523 48.03376180375574 1.3632626285163878 35.247275 35.247275 34.82915 0.5913180457668572 35.04033230800709 0.5138156047767293 79.05782500000001 79.05782500000001 76.47475 3.653019697626702 77.77938316055108 3.1742283845913697 0.0 47.47345 0.0 47.47345 47.47345;49.6922 34.82915;35.6654 76.47475;81.6409 3 0 2 286954;25146 UGT2B10_33303,UGT2B1_33224;CYP17A1_32365 48.582825 48.582825 1.5688931707576523 35.247275 35.247275 0.5913180457668572 79.05782500000001 79.05782500000001 3.653019697626702 47.47345;49.6922 34.82915;35.6654 76.47475;81.6409 0 0 Exp 2,2(0.67);Linear,1(0.34) 1.7714425559852034 5.324410319328308 1.6419988870620728 1.90940523147583 0.13371223133715565 1.7730062007904053 46.40845 50.7572 34.42775 36.0668 73.99499800000001 84.120652 UP 1.0 0.0 0.0 GO:0016192 4 vesicle-mediated transport 163 173 3 2 2 2 2 2 160 171 2214 7.0717E-4 0.9999 0.0011125 1.16 192235;29184 hyou1;cd36 HYOU1_8857;CD36_8243 44.1639 44.1639 40.1982 5.608346724303027 46.08998365745765 4.9024439281798715 33.46385 33.46385 29.3844 5.769213517022889 35.44518040230365 5.043062985806758 65.7496 65.7496 62.3571 4.797719510350716 67.39728863200067 4.1938474988908965 40.1982;48.1296 29.3844;37.5433 62.3571;69.1421 1 1 1 29184 CD36_8243 48.1296 48.1296 37.5433 37.5433 69.1421 69.1421 48.1296 37.5433 69.1421 1 192235 HYOU1_8857 40.1982 40.1982 29.3844 29.3844 62.3571 62.3571 40.1982 29.3844 62.3571 0 Exp 2,2(1) 2.1003804406660076 4.322402358055115 1.6520916223526 2.6703107357025146 0.7199896397834784 2.1612011790275574 36.391127999999995 51.936672 25.468128 41.459572 59.100300000000004 72.3989 CONFLICT 0.5 0.5 0.0 GO:0010664 10 negative regulation of striated muscle cell apoptotic process 11 13 3 3 3 3 3 3 159 10 2375 0.99283 0.045051 0.045051 23.08 81819;25675;50559 pax8;hmgcr;acot1 PAX8_9432;HMGCR_8810;ACOT1_7968 29.908596666666664 31.2018 1.63089 27.653792591017844 40.72519070018721 19.457585250763138 24.212445666666667 26.858 0.663137 22.344303990468273 33.31408651842739 14.815354050566624 42.15643333333333 37.2719 7.6286 37.211319425993665 54.977593693500936 30.07066139482436 0.0 1.63089 0.5 16.416345 56.8931;1.63089;31.2018 45.1162;0.663137;26.858 81.5688;7.6286;37.2719 2 1 2 81819;50559 PAX8_9432;ACOT1_7968 44.04745 44.04745 18.16649244749794 35.9871 35.9871 12.910497032260237 59.42035 59.42035 31.322638375542375 56.8931;31.2018 45.1162;26.858 81.5688;37.2719 1 25675 HMGCR_8810 1.63089 1.63089 0.663137 0.663137 7.6286 7.6286 1.63089 0.663137 7.6286 0 Exp 2,2(0.67);Exp 4,1(0.34) 10.46710882182744 347.7970345020294 1.7521979808807373 344.14306640625 197.636296447155 1.9017701148986816 -1.3846155425482678 61.201808875881596 -1.0725145838866368 49.49740591721997 0.04786136983609879 84.26500529683057 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0009725 4 response to hormone 388 419 68 67 50 61 45 45 117 374 2011 0.99995 1.1848E-4 1.6752E-4 10.74 79426;286954;246273;24825;170698;25351;24648;83516;29441;24651;25513;81819;25591;24314;24552;24516;63868;24471;29540;24464;113965;29328;24384;294515;314322;25661;361969;24890;29496;25315;116636;24330;140942;25146;497840;81718;114851;29184;25698;25373;192272;24158;312382;140668;25303 zfp36;ugt2b1;trib3;tf;slco1a2;slc2a2;serpina1;ppargc1a;por;pklr;pik3r1;pax8;parp1;nqo1;me1;jun;hspd1;hspb1;hsd17b7;hp;hadh;gpx4;gc;foxo3;fos;fn1;fga;esr1;erbb3;ephx1;eif4ebp1;egr1;ddit4;cyp17a1;cps1;cdo1;cdkn1a;cd36;ass1;ahsg;acot2;acadm;abcg2;abcc3;abcc2 ZFP36_10204;UGT2B10_33303,UGT2B1_33224;TRIB3_10079;TF_10003;SLCO1A2_9886;SLC2A2_9863;SERPINA1_9807;PPARGC1A_33189;POR_9531;PKLR_9489;PIK3R1_32562;PAX8_9432;PARP1_9425;NQO1_33055;ME1_9215;JUN_8938;HSPD1_8849;HSPB1_8847;HSD17B7_8834;HP_8823;HADH_8776;GPX4_32827;GC_32893;FOXO3_8662;FOS_8657;FN1_8655;FGA_8632;ESR1_33192;ERBB3_8571;EPHX1_8567;EIF4EBP1_8550;EGR1_8533;DDIT4_8450;CYP17A1_32365;CPS1_32421;CDO1_8275;CDKN1A_8271;CD36_8243;ASS1_33159;AHSG_8003;ACOT2_7969;ACADM_7957;ABCG2_32656;ABCC3_7941;ABCC2_32541 38.061434555555586 31.9826 1.28141E-12 29.25426257759867 37.64590122403052 25.74285732531878 26.453331400000035 23.9469 1.28141E-12 20.65228876707865 25.74122444558602 17.62732474497935 63.885301555555586 46.9856 1.28142E-12 51.76992941400605 62.371041242303704 42.23433066072847 19.5 27.7772 40.5 87.4093 0.348134;47.47345;108.064;45.1539;104.197;29.7555;15.797;42.4094;12.4414;23.0963;18.7324;56.8931;26.9741;87.2765;80.7944;16.4324;42.2579;89.1011;0.977494;64.9285;33.3125;45.9204;42.356;13.1992;1.28141E-12;59.5777;28.5803;23.3972;60.9984;12.4747;83.9001;0.750017;87.5421;49.6922;31.9826;22.9638;6.24967;48.1296;26.8037;12.402;8.54905;11.7137;5.21654;37.7175;46.2316 0.118102;34.82915;83.8836;28.132;80.3101;23.3399;13.013;26.2988;8.48981;17.4625;11.6701;45.1162;21.799;60.6992;59.856;10.5224;23.9469;60.3265;0.322682;41.6103;25.7336;34.2198;26.3722;5.6804;1.28141E-12;31.0499;22.529;18.3088;41.6036;7.00435;42.4185;0.186019;53.2453;35.6654;24.4836;18.5144;2.44025;37.5433;20.9825;10.3013;7.19676;8.36151;2.73368;30.9007;31.1788 1.15962;76.47475;143.428;61.5341;128.412;40.808;19.9134;81.7305;79.2355;32.9443;41.5978;81.5688;35.2797;197.117;94.0621;39.929;102.383;106.138;5.49472;136.455;46.9856;70.4292;78.7583;32.7581;1.28142E-12;105.243;38.8511;31.9156;113.972;23.684;107.32;4.70178;245.492;81.6409;45.5891;30.0179;19.0606;69.1421;36.7081;15.4235;10.4125;18.9642;11.386;48.9329;81.7848 18 28 17 286954;24825;81819;25591;24314;63868;113965;29328;29496;25315;116636;25146;29184;192272;24158;312382;140668 UGT2B10_33303,UGT2B1_33224;TF_10003;PAX8_9432;PARP1_9425;NQO1_33055;HSPD1_8849;HADH_8776;GPX4_32827;ERBB3_8571;EPHX1_8567;EIF4EBP1_8550;CYP17A1_32365;CD36_8243;ACOT2_7969;ACADM_7957;ABCG2_32656;ABCC3_7941 41.391390588235296 45.1539 23.867724968305907 28.700214705882356 30.9007 15.708420283046888 68.07216176470588 69.1421 46.61643367082152 47.47345;45.1539;56.8931;26.9741;87.2765;42.2579;33.3125;45.9204;60.9984;12.4747;83.9001;49.6922;48.1296;8.54905;11.7137;5.21654;37.7175 34.82915;28.132;45.1162;21.799;60.6992;23.9469;25.7336;34.2198;41.6036;7.00435;42.4185;35.6654;37.5433;7.19676;8.36151;2.73368;30.9007 76.47475;61.5341;81.5688;35.2797;197.117;102.383;46.9856;70.4292;113.972;23.684;107.32;81.6409;69.1421;10.4125;18.9642;11.386;48.9329 28 79426;246273;170698;25351;24648;83516;29441;24651;25513;24552;24516;24471;29540;24464;24384;294515;314322;25661;361969;24890;24330;140942;497840;81718;114851;25698;25373;25303 ZFP36_10204;TRIB3_10079;SLCO1A2_9886;SLC2A2_9863;SERPINA1_9807;PPARGC1A_33189;POR_9531;PKLR_9489;PIK3R1_32562;ME1_9215;JUN_8938;HSPB1_8847;HSD17B7_8834;HP_8823;GC_32893;FOXO3_8662;FOS_8657;FN1_8655;FGA_8632;ESR1_33192;EGR1_8533;DDIT4_8450;CPS1_32421;CDO1_8275;CDKN1A_8271;ASS1_33159;AHSG_8003;ABCC2_32541 36.03967553571433 25.100450000000002 32.3396748435195 25.089152250000044 19.74845 23.318047439284406 61.34327928571433 40.3685 55.33638434735692 0.348134;108.064;104.197;29.7555;15.797;42.4094;12.4414;23.0963;18.7324;80.7944;16.4324;89.1011;0.977494;64.9285;42.356;13.1992;1.28141E-12;59.5777;28.5803;23.3972;0.750017;87.5421;31.9826;22.9638;6.24967;26.8037;12.402;46.2316 0.118102;83.8836;80.3101;23.3399;13.013;26.2988;8.48981;17.4625;11.6701;59.856;10.5224;60.3265;0.322682;41.6103;26.3722;5.6804;1.28141E-12;31.0499;22.529;18.3088;0.186019;53.2453;24.4836;18.5144;2.44025;20.9825;10.3013;31.1788 1.15962;143.428;128.412;40.808;19.9134;81.7305;79.2355;32.9443;41.5978;94.0621;39.929;106.138;5.49472;136.455;78.7583;32.7581;1.28142E-12;105.243;38.8511;31.9156;4.70178;245.492;45.5891;30.0179;19.0606;36.7081;15.4235;81.7848 0 Exp 2,17(0.37);Exp 3,3(0.07);Exp 4,4(0.09);Hill,4(0.09);Linear,8(0.18);Poly 2,9(0.2);Power,1(0.03) 1.9947424352530325 100.50071215629578 1.5074360370635986 11.836054801940918 1.5474223879792262 1.8175725936889648 29.513937307550776 46.608931803560395 20.419154980978657 32.48750781902142 48.75918692450469 79.01141618660647 DOWN 0.37777777777777777 0.6222222222222222 0.0 GO:0090277 7 positive regulation of peptide hormone secretion 36 38 6 6 5 5 4 4 158 34 2351 0.91021 0.2196 0.30037 10.53 293615;100359982;24957;361969 sirt3;mpc2;glul;fga SIRT3_9828;MPC2_33219;GLUL_32832;FGA_8632 26.06842 27.523600000000002 2.38018 18.25122223338116 26.031747375641746 16.802222114500925 19.9965225 21.787300000000002 0.56209 14.56622689095195 20.050690470253244 13.455011959311937 38.0593925 37.1407 8.82917 24.678878089793535 37.596740020276975 22.534611005121736 0.5 14.42354 2.5 37.713300000000004 2.38018;46.8463;26.4669;28.5803 0.56209;35.8494;21.0456;22.529 8.82917;69.127;35.4303;38.8511 2 2 2 293615;100359982 SIRT3_9828;MPC2_33219 24.61324 24.61324 31.44229498505476 18.205745 18.205745 24.951896190831874 38.978085 38.978085 42.637004483833636 2.38018;46.8463 0.56209;35.8494 8.82917;69.127 2 24957;361969 GLUL_32832;FGA_8632 27.523600000000002 27.523600000000002 1.4943994713595314 21.787300000000002 21.787300000000002 1.0489221992120368 37.1407 37.1407 2.418870877082957 26.4669;28.5803 21.0456;22.529 35.4303;38.8511 0 Exp 2,1(0.25);Hill,1(0.25);Linear,2(0.5) 1.8064921326596484 7.347513794898987 1.5209722518920898 2.3622660636901855 0.3958762618605448 1.7321377396583557 8.182222211286465 43.954617788713534 5.721620146867094 34.27142485313291 13.874091972002333 62.24469302799767 CONFLICT 0.5 0.5 0.0 GO:0051412 6 response to corticosterone 23 27 5 5 3 5 3 3 159 24 2361 0.91178 0.24424 0.24424 11.11 294515;314322;114851 foxo3;fos;cdkn1a FOXO3_8662;FOS_8657;CDKN1A_8271 6.482956666667094 6.24967 1.28141E-12 6.602691660347697 6.0298703876794715 4.515689623874787 2.70688333333376 2.44025 1.28141E-12 2.8495712029759606 2.424865617176474 1.9361345370076584 17.27290000000043 19.0606 1.28142E-12 16.45205708627276 17.38741876185442 11.56122033381758 0.5 3.124835000000641 1.5 9.724435 13.1992;1.28141E-12;6.24967 5.6804;1.28141E-12;2.44025 32.7581;1.28142E-12;19.0606 0 3 0 3 294515;314322;114851 FOXO3_8662;FOS_8657;CDKN1A_8271 6.482956666667094 6.24967 6.602691660347697 2.70688333333376 2.44025 2.8495712029759606 17.27290000000043 19.0606 16.45205708627276 13.1992;1.28141E-12;6.24967 5.6804;1.28141E-12;2.44025 32.7581;1.28142E-12;19.0606 0 Exp 4,2(0.67);Hill,1(0.34) 1.7905051237805414 5.407113790512085 1.522104263305664 1.9883413314819336 0.24700847051274016 1.8966681957244873 -0.9886923159894732 13.95460564932366 -0.5177100408480659 5.931476707515587 -1.3443551914656133 35.89015519146646 DOWN 0.0 1.0 0.0 GO:0032264 8 IMP salvage 1 3 1 1 1 1 1 1 161 2 2383 0.98844 0.179 0.179 33.33 25028 ampd1 AMPD1_32743 60.9045 60.9045 60.9045 60.9045 50.0633 50.0633 50.0633 50.063300000000005 82.6625 82.6625 82.6625 82.6625 0.0 60.9045 0.0 60.9045 60.9045 50.0633 82.6625 1 0 1 25028 AMPD1_32743 60.9045 60.9045 50.0633 50.0633 82.6625 82.6625 60.9045 50.0633 82.6625 0 0 Exp 2,1(1) 1.571676254272461 1.571676254272461 1.571676254272461 1.571676254272461 0.0 1.571676254272461 60.9045 60.9045 50.0633 50.0633 82.6625 82.6625 UP 1.0 0.0 0.0 GO:0032722 7 positive regulation of chemokine production 25 28 2 2 2 2 2 2 160 26 2359 0.73822 0.5404 0.6976 7.14 24539;24330 lpl;egr1 LPL_32544;EGR1_8533 37.4770585 37.4770585 0.750017 51.9398801951395 43.63084934931912 51.20559413824937 25.0271095 25.0271095 0.186019 35.13060708923745 29.18935260923623 34.6339576002745 80.06339000000001 80.06339000000001 4.70178 106.57741094427186 92.69058693901718 105.07070152288289 0.5 37.4770585 74.2041;0.750017 49.8682;0.186019 155.425;4.70178 1 1 1 24539 LPL_32544 74.2041 74.2041 49.8682 49.8682 155.425 155.425 74.2041 49.8682 155.425 1 24330 EGR1_8533 0.750017 0.750017 0.186019 0.186019 4.70178 4.70178 0.750017 0.186019 4.70178 0 Exp 2,1(0.5);Hill,1(0.5) 2.5647594087358567 5.777684688568115 1.559399127960205 4.21828556060791 1.8801166269301006 2.8888423442840576 -34.50794284 109.46205984 -23.661427879999998 73.71564688000001 -67.64536559999998 227.7721456 CONFLICT 0.5 0.5 0.0 GO:0043434 5 response to peptide hormone 194 204 35 34 26 30 22 22 140 182 2203 0.99601 0.0083066 0.010601 10.78 286954;246273;25351;29441;24651;25513;25591;24471;29540;24464;113965;25661;361969;29496;24330;497840;81718;29184;25698;25373;312382;25303 ugt2b1;trib3;slc2a2;por;pklr;pik3r1;parp1;hspb1;hsd17b7;hp;hadh;fn1;fga;erbb3;egr1;cps1;cdo1;cd36;ass1;ahsg;abcg2;abcc2 UGT2B10_33303,UGT2B1_33224;TRIB3_10079;SLC2A2_9863;POR_9531;PKLR_9489;PIK3R1_32562;PARP1_9425;HSPB1_8847;HSD17B7_8834;HP_8823;HADH_8776;FN1_8655;FGA_8632;ERBB3_8571;EGR1_8533;CPS1_32421;CDO1_8275;CD36_8243;ASS1_33159;AHSG_8003;ABCG2_32656;ABCC2_32541 36.29513640909091 29.167900000000003 0.750017 27.480613165704625 37.76300445920658 26.008054281162575 25.93514731818182 22.93445 0.186019 19.637252338573507 26.63477023269406 18.02461667936881 58.984579545454544 43.593450000000004 4.70178 41.26918500123542 61.65117411416811 40.55867124028918 9.5 27.7772 19.5 77.01480000000001 47.47345;108.064;29.7555;12.4414;23.0963;18.7324;26.9741;89.1011;0.977494;64.9285;33.3125;59.5777;28.5803;60.9984;0.750017;31.9826;22.9638;48.1296;26.8037;12.402;5.21654;46.2316 34.82915;83.8836;23.3399;8.48981;17.4625;11.6701;21.799;60.3265;0.322682;41.6103;25.7336;31.0499;22.529;41.6036;0.186019;24.4836;18.5144;37.5433;20.9825;10.3013;2.73368;31.1788 76.47475;143.428;40.808;79.2355;32.9443;41.5978;35.2797;106.138;5.49472;136.455;46.9856;105.243;38.8511;113.972;4.70178;45.5891;30.0179;69.1421;36.7081;15.4235;11.386;81.7848 7 16 6 286954;25591;113965;29496;29184;312382 UGT2B10_33303,UGT2B1_33224;PARP1_9425;HADH_8776;ERBB3_8571;CD36_8243;ABCG2_32656 37.01743166666667 40.392975 19.666149532005917 27.373721666666665 30.281374999999997 14.159041963142023 58.87335833333333 58.06385 35.78867158963038 47.47345;26.9741;33.3125;60.9984;48.1296;5.21654 34.82915;21.799;25.7336;41.6036;37.5433;2.73368 76.47475;35.2797;46.9856;113.972;69.1421;11.386 16 246273;25351;29441;24651;25513;24471;29540;24464;25661;361969;24330;497840;81718;25698;25373;25303 TRIB3_10079;SLC2A2_9863;POR_9531;PKLR_9489;PIK3R1_32562;HSPB1_8847;HSD17B7_8834;HP_8823;FN1_8655;FGA_8632;EGR1_8533;CPS1_32421;CDO1_8275;ASS1_33159;AHSG_8003;ABCC2_32541 36.024275687499994 27.692 30.46394021464971 25.3956819375 21.75575 21.723396876374196 59.0262875 41.2029 44.24312460291376 108.064;29.7555;12.4414;23.0963;18.7324;89.1011;0.977494;64.9285;59.5777;28.5803;0.750017;31.9826;22.9638;26.8037;12.402;46.2316 83.8836;23.3399;8.48981;17.4625;11.6701;60.3265;0.322682;41.6103;31.0499;22.529;0.186019;24.4836;18.5144;20.9825;10.3013;31.1788 143.428;40.808;79.2355;32.9443;41.5978;106.138;5.49472;136.455;105.243;38.8511;4.70178;45.5891;30.0179;36.7081;15.4235;81.7848 0 Exp 2,10(0.44);Exp 4,2(0.09);Hill,1(0.05);Linear,5(0.22);Poly 2,4(0.18);Power,1(0.05) 1.9524680325372887 46.56704878807068 1.5074360370635986 4.21828556060791 0.6505136231924662 1.8086696863174438 24.8117190399644 47.7785537782174 17.729261837135894 34.141032799227744 41.739284726330354 76.22987436457873 DOWN 0.2727272727272727 0.7272727272727273 0.0 GO:0005975 4 carbohydrate metabolic process 100 118 17 17 14 15 12 12 150 106 2279 0.96603 0.068107 0.11766 10.17 286954;29573;25106;501907;192280;83516;24651;25513;25685;114860;24158;312382 ugt2b1;slc37a4;rgn;rgd1559459;ppp1r3b;ppargc1a;pklr;pik3r1;igfbp1;gale;acadm;abcg2 UGT2B10_33303,UGT2B1_33224;SLC37A4_9871;RGN_9699;RGD1559459_9690;PPP1R3B_9545;PPARGC1A_33189;PKLR_9489;PIK3R1_32562;IGFBP1_32306;GALE_8680;ACADM_7957;ABCG2_32656 35.17617416666669 37.92885 2.52378E-13 24.4928896398342 34.99100508686594 22.542901110953473 23.82092000000002 24.49495 2.52378E-13 17.208228693585653 23.99174399810298 16.408982838393648 53.71880416666669 56.828900000000004 2.52379E-13 32.47783962644551 53.288618821493145 29.60051970863254 4.5 29.6187 10.5 74.29435000000001 47.47345;39.7166;77.4407;2.52378E-13;36.1411;42.4094;23.0963;18.7324;49.0259;71.148;11.7137;5.21654 34.82915;22.6911;58.7732;2.52378E-13;27.0588;26.2988;17.4625;11.6701;32.6883;43.2839;8.36151;2.73368 76.47475;60.0334;89.8047;2.52379E-13;53.6244;81.7305;32.9443;41.5978;89.1623;88.9033;18.9642;11.386 5 8 4 286954;25106;24158;312382 UGT2B10_33303,UGT2B1_33224;RGN_9699;ACADM_7957;ABCG2_32656 35.4610975 29.593575 33.59194241201341 26.174385 21.59533 25.847971314799544 49.1574125 47.719475 39.73557848457675 47.47345;77.4407;11.7137;5.21654 34.82915;58.7732;8.36151;2.73368 76.47475;89.8047;18.9642;11.386 8 29573;501907;192280;83516;24651;25513;25685;114860 SLC37A4_9871;RGD1559459_9690;PPP1R3B_9545;PPARGC1A_33189;PKLR_9489;PIK3R1_32562;IGFBP1_32306;GALE_8680 35.033712500000036 37.92885 21.424869391596335 22.644187500000037 24.49495 13.200480695623693 55.99950000000004 56.828900000000004 31.032987929160544 39.7166;2.52378E-13;36.1411;42.4094;23.0963;18.7324;49.0259;71.148 22.6911;2.52378E-13;27.0588;26.2988;17.4625;11.6701;32.6883;43.2839 60.0334;2.52379E-13;53.6244;81.7305;32.9443;41.5978;89.1623;88.9033 0 Exp 2,6(0.47);Exp 4,1(0.08);Hill,1(0.08);Poly 2,5(0.39) 1.9021386368469784 25.658636212348938 1.5074360370635986 3.9562058448791504 0.6620075437146002 1.7576230764389038 21.31801726841241 49.034331064920956 14.084448040852072 33.55739195914797 35.34273650466139 72.09487182867198 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0051443 9 positive regulation of ubiquitin-protein transferase activity 9 9 1 1 1 1 1 1 161 8 2377 0.89218 0.44701 0.44701 11.11 246273 trib3 TRIB3_10079 108.064 108.064 108.064 108.06400000000001 83.8836 83.8836 83.8836 83.8836 143.428 143.428 143.428 143.428 0.0 108.064 0.0 108.064 108.064 83.8836 143.428 0 1 0 1 246273 TRIB3_10079 108.064 108.064 83.8836 83.8836 143.428 143.428 108.064 83.8836 143.428 0 Poly 2,1(1) 1.87713623046875 1.87713623046875 1.87713623046875 1.87713623046875 0.0 1.87713623046875 108.064 108.064 83.8836 83.8836 143.428 143.428 DOWN 0.0 1.0 0.0 GO:1900180 7 regulation of protein localization to nucleus 47 51 5 5 4 5 4 4 158 47 2338 0.77892 0.40937 0.56295 7.84 25513;25591;24957;29184 pik3r1;parp1;glul;cd36 PIK3R1_32562;PARP1_9425;GLUL_32832;CD36_8243 30.07575 26.7205 18.7324 12.612918246649613 33.56053264698586 13.190391914217779 23.014499999999998 21.4223 11.6701 10.725910190748388 26.096660092615565 10.748154002039982 45.362475 38.51405 35.2797 16.12403790336548 48.61674841643926 18.23713956874053 1.5 26.7205 18.7324;26.9741;26.4669;48.1296 11.6701;21.799;21.0456;37.5433 41.5978;35.2797;35.4303;69.1421 2 2 2 25591;29184 PARP1_9425;CD36_8243 37.55185 37.55185 14.959197509391997 29.67115 29.67115 11.132901295035358 52.210899999999995 52.210899999999995 23.944332667251356 26.9741;48.1296 21.799;37.5433 35.2797;69.1421 2 25513;24957 PIK3R1_32562;GLUL_32832 22.599649999999997 22.599649999999997 5.469117399087357 16.35785 16.35785 6.629479627014474 38.51405 38.51405 4.36108107296816 18.7324;26.4669 11.6701;21.0456 41.5978;35.4303 0 Exp 2,2(0.5);Linear,1(0.25);Poly 2,1(0.25) 2.090374460577833 8.514826536178589 1.6735800504684448 2.6703107357025146 0.46813419197820666 2.0854678750038147 17.715090118283378 42.43640988171662 12.503108013066587 33.525891986933416 29.560917854701827 61.164032145298165 CONFLICT 0.5 0.5 0.0 GO:0051129 6 negative regulation of cellular component organization 177 187 7 7 4 6 4 4 158 183 2202 0.005434 0.99851 0.011666 2.14 83516;25591;116636;170465 ppargc1a;parp1;eif4ebp1;acaa2 PPARGC1A_33189;PARP1_9425;EIF4EBP1_8550;ACAA2_7955 44.967699999999994 34.69175 26.5872 26.980790017220283 43.108279866709665 26.782649793364662 27.971449999999997 24.0489 21.3695 9.886015283048417 27.342346805689917 9.789690925731469 64.842725 58.5051 35.0407 35.8313130149571 61.09502644308288 35.838211173932464 42.4094;26.9741;83.9001;26.5872 26.2988;21.799;42.4185;21.3695 81.7305;35.2797;107.32;35.0407 3 1 3 25591;116636;170465 PARP1_9425;EIF4EBP1_8550;ACAA2_7955 45.82046666666667 26.9741 32.97849722172515 28.528999999999996 21.799 12.030576679860372 59.21346666666667 35.2797 41.66165133865115 26.9741;83.9001;26.5872 21.799;42.4185;21.3695 35.2797;107.32;35.0407 1 83516 PPARGC1A_33189 42.4094 42.4094 26.2988 26.2988 81.7305 81.7305 42.4094 26.2988 81.7305 0 Exp 2,3(0.75);Exp 3,1(0.25) 1.9701948939576466 8.072455048561096 1.672852873802185 2.8333094120025635 0.5463427638411794 1.7831463813781738 18.526525783124136 71.40887421687586 18.28315502261256 37.65974497738744 29.728038245342063 99.95741175465794 UP 0.75 0.25 0.0 GO:2001259 7 positive regulation of cation channel activity 16 16 2 2 2 2 2 2 160 14 2371 0.92323 0.27077 0.27077 12.5 362895;81869 stac3;gstm7 STAC3_9953;GSTM7_8761 52.777249999999995 52.777249999999995 42.3152 14.795573000225469 53.11037200887687 14.78807086334813 37.0533 37.0533 31.4035 7.990023784695507 37.23319521420301 7.985972420676993 93.05955 93.05955 64.5991 40.2491543812414 93.96575884793516 40.22874593437936 0.0 42.3152 0.5 52.777249999999995 63.2393;42.3152 42.7031;31.4035 121.52;64.5991 1 1 1 81869 GSTM7_8761 42.3152 42.3152 31.4035 31.4035 64.5991 64.5991 42.3152 31.4035 64.5991 1 362895 STAC3_9953 63.2393 63.2393 42.7031 42.7031 121.52 121.52 63.2393 42.7031 121.52 0 Linear,2(1) 2.244761387060541 4.629303574562073 1.7501527070999146 2.879150867462158 0.7983222551392797 2.3146517872810364 32.271632 73.282868 25.979692000000004 48.126908 37.277068000000014 148.842032 CONFLICT 0.5 0.5 0.0 GO:0046486 5 glycerolipid metabolic process 62 68 13 13 7 13 7 7 155 61 2324 0.93627 0.13764 0.19962 10.29 29573;246074;25513;24539;497840;362866;29184 slc37a4;scd;pik3r1;lpl;cps1;chpt1;cd36 SLC37A4_9871;SCD1_9787;PIK3R1_32562;LPL_32544;CPS1_32421;CHPT1_33298;CD36_8243 47.754457142857134 39.7166 16.0559 32.1198042926716 47.699166678489874 28.092285677521097 31.515942857142857 24.4836 10.6021 19.878602917614465 32.071644687312954 17.93641958375876 117.7702 60.0334 29.905 140.73043162155798 103.79669933051053 114.75448655080694 2.5 35.8496 5.5 89.83205 39.7166;105.46;18.7324;74.2041;31.9826;16.0559;48.1296 22.6911;63.7532;11.6701;49.8682;24.4836;10.6021;37.5433 60.0334;422.699;41.5978;155.425;45.5891;29.905;69.1421 4 3 4 246074;24539;362866;29184 SCD1_9787;LPL_32544;CHPT1_33298;CD36_8243 60.9624 61.16685 38.020404709138305 40.4417 43.70575 22.59120319372123 169.292775 112.28355 176.8861588466883 105.46;74.2041;16.0559;48.1296 63.7532;49.8682;10.6021;37.5433 422.699;155.425;29.905;69.1421 3 29573;25513;497840 SLC37A4_9871;PIK3R1_32562;CPS1_32421 30.143866666666668 31.9826 10.612250826913822 19.61493333333333 22.6911 6.938555078929153 49.073433333333334 45.5891 9.699137638127038 39.7166;18.7324;31.9826 22.6911;11.6701;24.4836 60.0334;41.5978;45.5891 0 Exp 2,4(0.58);Poly 2,3(0.43) 1.8890520301865792 13.45242428779602 1.559399127960205 2.6703107357025146 0.4022725787059091 1.8264755010604858 23.959773133684457 71.54914115202985 16.789667732347812 46.2422179819379 13.515637288561663 222.02476271143834 CONFLICT 0.5714285714285714 0.42857142857142855 0.0 GO:0051602 4 response to electrical stimulus 25 25 4 4 4 4 4 4 158 21 2364 0.98162 0.070079 0.070079 16.0 83516;24314;24464;24330 ppargc1a;nqo1;hp;egr1 PPARGC1A_33189;NQO1_33055;HP_8823;EGR1_8533 48.84110425 53.668949999999995 0.750017 36.92426230778717 40.47236299406199 33.08136008552819 32.19857975 33.95455 0.186019 25.563497932077038 25.85765365998841 21.823005876577053 105.00107 109.09275000000001 4.70178 81.80497392139185 84.74420078497634 69.42894081352476 0.5 21.5797085 1.5 53.668949999999995 42.4094;87.2765;64.9285;0.750017 26.2988;60.6992;41.6103;0.186019 81.7305;197.117;136.455;4.70178 1 3 1 24314 NQO1_33055 87.2765 87.2765 60.6992 60.6992 197.117 197.117 87.2765 60.6992 197.117 3 83516;24464;24330 PPARGC1A_33189;HP_8823;EGR1_8533 36.029305666666666 42.4094 32.561459162973584 22.698373000000004 26.2988 20.945526253319272 74.29576000000002 81.7305 66.19051491144934 42.4094;64.9285;0.750017 26.2988;41.6103;0.186019 81.7305;136.455;4.70178 0 Exp 2,3(0.75);Hill,1(0.25) 2.090464308858598 9.186262130737305 1.576730489730835 4.21828556060791 1.283370837848799 1.6956230401992798 12.655327188368581 85.02688131163143 7.146351776564508 57.25080772343549 24.832195557036002 185.16994444296398 DOWN 0.25 0.75 0.0 GO:0051282 4 regulation of sequestering of calcium ion 38 39 2 2 2 2 2 2 160 37 2348 0.5439 0.72107 1.0 5.13 81678;81869 itpr2;gstm7 ITPR2_8931;GSTM7_8761 37.06315 37.06315 31.8111 7.427520340261584 35.924037618044174 7.25071750708508 28.06885 28.06885 24.7342 4.715907255767456 27.345600772652777 4.6036509810457344 54.46435 54.46435 44.3296 14.332700901260717 52.26623322406931 13.991528880138322 0.5 37.06315 31.8111;42.3152 24.7342;31.4035 44.3296;64.5991 1 1 1 81869 GSTM7_8761 42.3152 42.3152 31.4035 31.4035 64.5991 64.5991 42.3152 31.4035 64.5991 1 81678 ITPR2_8931 31.8111 31.8111 24.7342 24.7342 44.3296 44.3296 31.8111 24.7342 44.3296 0 Linear,2(1) 1.7083263265350617 3.4176522493362427 1.6674995422363281 1.7501527070999146 0.05844461336157165 1.7088261246681213 26.769132000000006 47.357167999999994 21.532936 34.604764 34.60024 74.32846 CONFLICT 0.5 0.5 0.0 GO:2000378 7 negative regulation of reactive oxygen species metabolic process 32 33 4 4 4 4 4 4 158 29 2356 0.94539 0.1542 0.1542 12.12 293615;25106;63868;24464 sirt3;rgn;hspd1;hp SIRT3_9828;RGN_9699;HSPD1_8849;HP_8823 46.75182 53.593199999999996 2.38018 32.970880105191824 48.701292057439964 31.088669262129216 31.223122500000002 32.7786 0.56209 24.89941468192961 32.178562218783526 23.33197330182588 84.36796749999999 96.09385 8.82917 54.07793246372831 90.9312198658909 53.188532796020056 0.5 22.31904 2.5 71.1846 2.38018;77.4407;42.2579;64.9285 0.56209;58.7732;23.9469;41.6103 8.82917;89.8047;102.383;136.455 3 1 3 293615;25106;63868 SIRT3_9828;RGN_9699;HSPD1_8849 40.69292666666667 42.2579 37.55472369513765 27.76073 23.9469 29.292359179651275 67.00562333333333 89.8047 50.77330203519004 2.38018;77.4407;42.2579 0.56209;58.7732;23.9469 8.82917;89.8047;102.383 1 24464 HP_8823 64.9285 64.9285 41.6103 41.6103 136.455 136.455 64.9285 41.6103 136.455 0 Exp 2,1(0.25);Exp 3,1(0.25);Hill,1(0.25);Poly 2,1(0.25) 1.7612788744080468 7.126332402229309 1.5209722518920898 2.2518506050109863 0.3239177857565391 1.6767547726631165 14.440357496912021 79.06328250308798 6.8216961117089845 55.62454888829102 31.37159368554628 137.36434131445372 UP 0.75 0.25 0.0 GO:0042246 4 tissue regeneration 26 26 3 3 3 3 3 3 159 23 2362 0.92111 0.2269 0.2269 11.54 85253;25685;114851 plg;igfbp1;cdkn1a PLG_9501;IGFBP1_32306;CDKN1A_8271 42.02042333333333 49.0259 6.24967 32.83340249708569 37.27177976374925 38.14886950800389 27.12138333333333 32.6883 2.44025 22.42211165982886 23.58340444481072 25.933512129643894 86.26730000000002 89.1623 19.0606 65.80697647962562 81.00697823196529 77.34826006067428 0.5 27.637785 1.5 59.9058 70.7857;49.0259;6.24967 46.2356;32.6883;2.44025 150.579;89.1623;19.0606 0 3 0 3 85253;25685;114851 PLG_9501;IGFBP1_32306;CDKN1A_8271 42.02042333333333 49.0259 32.83340249708569 27.12138333333333 32.6883 22.42211165982886 86.26730000000002 89.1623 65.80697647962562 70.7857;49.0259;6.24967 46.2356;32.6883;2.44025 150.579;89.1623;19.0606 0 Exp 2,1(0.34);Exp 4,1(0.34);Linear,1(0.34) 2.0943160894717066 7.003779172897339 1.522104263305664 3.9562058448791504 1.4043588766030017 1.5254690647125244 4.865930743929972 79.17491592273669 1.7483754162333334 52.49439125043334 11.799695853268233 160.73490414673176 DOWN 0.0 1.0 0.0 GO:0071456 5 cellular response to hypoxia 57 60 11 11 10 9 8 8 154 52 2333 0.98786 0.033839 0.05232 13.33 83516;81678;192235;294515;24360;116636;24330;170465 ppargc1a;itpr2;hyou1;foxo3;fabp1;eif4ebp1;egr1;acaa2 PPARGC1A_33189;ITPR2_8931;HYOU1_8857;FOXO3_8662;FABP1_33091;EIF4EBP1_8550;EGR1_8533;ACAA2_7955 34.087877125 32.82945 0.750017 24.48641779356613 35.404766596265915 25.191078160152315 22.068177374999998 25.5165 0.186019 13.41615545257 23.17462794990587 12.959697456667424 51.895435 45.62765 4.70178 31.692632816441748 51.871541959386775 33.09858853470292 2.0 26.5872 5.0 40.1982 42.4094;31.8111;40.1982;13.1992;33.8478;83.9001;0.750017;26.5872 26.2988;24.7342;29.3844;5.6804;26.4736;42.4185;0.186019;21.3695 81.7305;44.3296;62.3571;32.7581;46.9257;107.32;4.70178;35.0407 3 5 3 24360;116636;170465 FABP1_33091;EIF4EBP1_8550;ACAA2_7955 48.111700000000006 33.8478 31.20554852922793 30.0872 26.4736 10.979921628590972 63.09546666666666 46.9257 38.7578420150469 33.8478;83.9001;26.5872 26.4736;42.4185;21.3695 46.9257;107.32;35.0407 5 83516;81678;192235;294515;24330 PPARGC1A_33189;ITPR2_8931;HYOU1_8857;FOXO3_8662;EGR1_8533 25.673583400000002 31.8111 18.065959412431653 17.256763799999998 24.7342 13.324531487292612 45.175416 44.3296 29.259634241276498 42.4094;31.8111;40.1982;13.1992;0.750017 26.2988;24.7342;29.3844;5.6804;0.186019 81.7305;44.3296;62.3571;32.7581;4.70178 0 Exp 2,4(0.5);Exp 3,1(0.13);Exp 4,1(0.13);Hill,1(0.13);Linear,1(0.13) 2.087784203839529 17.665345907211304 1.6520916223526 4.21828556060791 0.9009175726829666 1.8164827823638916 17.11965529757841 51.0560989524216 12.771255966994184 31.36509878300582 29.933560933401964 73.85730906659805 DOWN 0.375 0.625 0.0 GO:0006732 5 coenzyme metabolic process 61 67 21 21 11 19 10 10 152 57 2328 0.99721 0.0086341 0.0086341 14.93 25106;298490;100359982;25675;83842;192272;170570;50559;170465;296925 rgn;ppcs;mpc2;hmgcr;crot;acot2;acot12;acot1;acaa2;aass RGN_9699;PPCS_9540;MPC2_33219;HMGCR_8810;CROT_8384;ACOT2_7969;ACOT12_32718;ACOT1_7968;ACAA2_7955;AASS_7936 27.782083999999998 27.0258 1.63089 22.042750934072643 32.821572579323835 18.968063229789827 21.899686699999997 21.559649999999998 0.663137 16.79199478075359 26.11329269470767 14.17923897085501 36.34045 36.0351 7.6286 26.3456272928524 42.1970009883638 22.416780587892816 2.5 14.442174999999999 5.5 28.903350000000003 77.4407;20.3353;46.8463;1.63089;7.4229;8.54905;30.3423;31.2018;26.5872;27.4644 58.7732;16.7643;35.8494;0.663137;5.75707;7.19676;24.0157;26.858;21.3695;21.7498 89.8047;25.6711;69.127;7.6286;10.316;10.4125;41.1025;37.2719;35.0407;37.0295 9 1 9 25106;298490;100359982;83842;192272;170570;50559;170465;296925 RGN_9699;PPCS_9540;MPC2_33219;CROT_8384;ACOT2_7969;ACOT12_32718;ACOT1_7968;ACAA2_7955;AASS_7936 30.68777222222222 27.4644 21.251687152569673 24.259303333333335 21.7498 15.9555579633885 39.530655555555555 37.0295 25.813905320781625 77.4407;20.3353;46.8463;7.4229;8.54905;30.3423;31.2018;26.5872;27.4644 58.7732;16.7643;35.8494;5.75707;7.19676;24.0157;26.858;21.3695;21.7498 89.8047;25.6711;69.127;10.316;10.4125;41.1025;37.2719;35.0407;37.0295 1 25675 HMGCR_8810 1.63089 1.63089 0.663137 0.663137 7.6286 7.6286 1.63089 0.663137 7.6286 0 Exp 2,5(0.5);Exp 4,1(0.1);Linear,2(0.2);Poly 2,2(0.2) 4.497165411506258 376.3297197818756 1.7093055248260498 344.14306640625 107.74365924221469 2.1501917243003845 14.119845425895184 41.44432257410482 11.49190050689115 32.30747289310885 20.011261028263345 52.669638971736646 UP 0.9 0.1 0.0 GO:0072594 6 establishment of protein localization to organelle 64 68 7 7 6 7 6 6 156 62 2323 0.86236 0.26196 0.44302 8.82 171139;25513;25493;63868;85255;114851 timm9;pik3r1;nfkbia;hspd1;hacl1;cdkn1a TIMM9_10020;PIK3R1_32562;NFKBIA_9307;HSPD1_8849;HACL1_8775;CDKN1A_8271 171139(0.04986) 20.65112016666667 18.179949999999998 0.520151 16.802375371197137 19.688076506990264 16.279877168196577 13.160408666666667 11.432549999999999 0.160202 11.618761773280777 11.44719564828778 10.195008745200916 43.174715 39.6256 2.88499 34.33506145421251 46.139153524976436 36.891448501710286 2.5 18.179949999999998 38.5191;18.7324;0.520151;42.2579;17.6275;6.24967 29.55;11.6701;0.160202;23.9469;11.195;2.44025 55.4685;41.5978;2.88499;102.383;37.6534;19.0606 3 3 3 171139;63868;85255 TIMM9_10020;HSPD1_8849;HACL1_8775 32.801500000000004 38.5191 13.273370459683536 21.56396666666667 23.9469 9.40666171940573 65.1683 55.4685 33.43717794715935 38.5191;42.2579;17.6275 29.55;23.9469;11.195 55.4685;102.383;37.6534 3 25513;25493;114851 PIK3R1_32562;NFKBIA_9307;CDKN1A_8271 8.500740333333333 6.24967 9.312464316372456 4.756850666666666 2.44025 6.094621971804432 21.18113 19.0606 19.44332533633843 18.7324;0.520151;6.24967 11.6701;0.160202;2.44025 41.5978;2.88499;19.0606 0 Exp 2,1(0.17);Exp 3,1(0.17);Exp 4,2(0.34);Poly 2,2(0.34) 1.7590187025997488 10.640898823738098 1.522104263305664 2.2518506050109863 0.2588438095926062 1.695812702178955 7.2064197654609 34.09582056787243 3.8634629894190997 22.457354343914233 15.700943922358285 70.6484860776417 CONFLICT 0.5 0.5 0.0 GO:0001544 4 initiation of primordial ovarian follicle growth 1 1 1 1 1 1 1 1 161 0 2385 1.0 0.063604 0.063604 100.0 294515 foxo3 FOXO3_8662 13.1992 13.1992 13.1992 13.1992 5.6804 5.6804 5.6804 5.6804 32.7581 32.7581 32.7581 32.7581 0.0 13.1992 0.0 13.1992 13.1992 5.6804 32.7581 0 1 0 1 294515 FOXO3_8662 13.1992 13.1992 5.6804 5.6804 32.7581 32.7581 13.1992 5.6804 32.7581 0 Exp 4,1(1) 1.9883413314819336 1.9883413314819336 1.9883413314819336 1.9883413314819336 0.0 1.9883413314819336 13.1992 13.1992 5.6804 5.6804 32.7581 32.7581 DOWN 0.0 1.0 0.0 GO:0007154 3 cell communication 162 169 18 18 16 13 11 11 151 158 2227 0.61162 0.51582 0.87082 6.51 362895;29482;85253;24539;24516;24957;294515;314322;170945;114851;246142 stac3;slc1a2;plg;lpl;jun;glul;foxo3;fos;chrna2;cdkn1a;bmf STAC3_9953;SLC1A2_33059;PLG_9501;LPL_32544;JUN_8938;GLUL_32832;FOXO3_8662;FOS_8657;CHRNA2_32401;CDKN1A_8271;BMF_8152 38.92443363636375 26.4669 1.28141E-12 32.6377820397011 48.16672774005795 33.44010590700089 27.50833363636375 21.0456 1.28141E-12 24.28869718539549 34.57423754279118 25.08172963220349 68.33630000000012 39.929 1.28142E-12 55.76204910309503 81.88241878609688 56.44914037295817 7.5 67.0125 63.2393;13.3235;70.7857;74.2041;16.4324;26.4669;13.1992;1.28141E-12;49.3913;6.24967;94.8767 42.7031;9.10952;46.2356;49.8682;10.5224;21.0456;5.6804;1.28141E-12;41.8524;2.44025;73.1342 121.52;24.6773;150.579;155.425;39.929;35.4303;32.7581;1.28142E-12;62.472;19.0606;109.848 3 8 3 24539;170945;246142 LPL_32544;CHRNA2_32401;BMF_8152 72.82403333333333 74.2041 22.774082666340956 54.951600000000006 49.8682 16.248645158289353 109.24833333333333 109.848 46.47940137666719 74.2041;49.3913;94.8767 49.8682;41.8524;73.1342 155.425;62.472;109.848 8 362895;29482;85253;24516;24957;294515;314322;114851 STAC3_9953;SLC1A2_33059;PLG_9501;JUN_8938;GLUL_32832;FOXO3_8662;FOS_8657;CDKN1A_8271 26.21208375000016 14.87795 26.388718331386343 17.21710875000016 9.81596 17.986892399221652 52.99428750000016 34.0942 53.27689059766454 63.2393;13.3235;70.7857;16.4324;26.4669;13.1992;1.28141E-12;6.24967 42.7031;9.10952;46.2356;10.5224;21.0456;5.6804;1.28141E-12;2.44025 121.52;24.6773;150.579;39.929;35.4303;32.7581;1.28142E-12;19.0606 0 Exp 2,2(0.19);Exp 4,2(0.19);Hill,1(0.1);Linear,3(0.28);Poly 2,3(0.28) 1.915749252771379 21.551990628242493 1.522104263305664 2.879150867462158 0.45246608406030564 1.8966681957244873 19.63673700458428 58.21213026814323 13.154630853398714 41.862036419328795 35.383034813088614 101.28956518691163 DOWN 0.2727272727272727 0.7272727272727273 0.0 GO:1901615 4 organic hydroxy compound metabolic process 134 145 34 34 22 27 17 17 145 128 2257 0.99609 0.0089781 0.012552 11.72 24856;293688;360268;29573;65192;29500;29540;25675;24443;24384;246186;25315;298541;25428;25146;25284;65183 ttr;tm7sf2;sult1e1;slc37a4;slc27a2;slc10a2;hsd17b7;hmgcr;hdc;gc;fgl1;ephx1;dhdds;cyp7a1;cyp17a1;amacr;aldh3a2 TTR_10102;TM7SF2_10031;SULT1E1_32446;SLC37A4_9871;SLC27A2_9860;SLC10A2_9833;HSD17B7_8834;HMGCR_8810;HDC_8788;GC_32893;FGL1_8640;EPHX1_8567;DHDDS_8467;CYP7A1_8430;CYP17A1_32365;AMACR_8038;ALDH3A2_8024 31.120623176470584 39.7166 0.977494 24.111035614628715 31.823934786119917 21.961797256157908 20.68399423529412 22.6911 0.322682 16.212301606881653 20.72642588660341 14.476699333043738 56.790431176470584 60.0334 3.73641 51.57101511809103 56.93144206790532 46.95757898432062 6.5 20.025100000000002 13.5 49.9384 46.6406;82.3097;50.1846;39.7166;7.62189;56.585;0.977494;1.63089;24.5745;42.356;15.4757;12.4747;47.9438;5.72128;49.6922;2.03774;43.1079 28.5876;51.1696;36.5009;22.6911;5.49916;35.2796;0.322682;0.663137;21.0619;26.3722;10.2138;7.00435;36.5688;0.985273;35.6654;1.165;31.8774 63.7146;209.842;80.9788;60.0334;13.3925;116.8;5.49472;7.6286;29.28;78.7583;30.4106;23.684;71.3742;22.3625;81.6409;3.73641;66.3058 9 8 9 24856;360268;65192;24443;25315;298541;25146;25284;65183 TTR_10102;SULT1E1_32446;SLC27A2_9860;HDC_8788;EPHX1_8567;DHDDS_8467;CYP17A1_32365;AMACR_8038;ALDH3A2_8024 31.58643666666667 43.1079 19.88245563729994 22.658945555555558 28.5876 14.484669952062342 48.23413444444444 63.7146 30.50793531236058 46.6406;50.1846;7.62189;24.5745;12.4747;47.9438;49.6922;2.03774;43.1079 28.5876;36.5009;5.49916;21.0619;7.00435;36.5688;35.6654;1.165;31.8774 63.7146;80.9788;13.3925;29.28;23.684;71.3742;81.6409;3.73641;66.3058 8 293688;29573;29500;29540;25675;24384;246186;25428 TM7SF2_10031;SLC37A4_9871;SLC10A2_9833;HSD17B7_8834;HMGCR_8810;GC_32893;FGL1_8640;CYP7A1_8430 30.596583000000003 27.59615 29.604117697382726 18.462174 16.45245 18.71736584640895 66.41626500000001 45.222 69.39235788563525 82.3097;39.7166;56.585;0.977494;1.63089;42.356;15.4757;5.72128 51.1696;22.6911;35.2796;0.322682;0.663137;26.3722;10.2138;0.985273 209.842;60.0334;116.8;5.49472;7.6286;78.7583;30.4106;22.3625 0 Exp 2,4(0.24);Exp 3,1(0.06);Exp 4,3(0.18);Hill,3(0.18);Linear,3(0.18);Poly 2,3(0.18) 2.1486205058093755 48.97302031517029 1.511321783065796 17.513065338134766 3.83753965747136 1.7512425184249878 19.65896439405876 42.58228195888242 12.977155256429047 28.390833214159183 32.2751267410388 81.30573561190238 CONFLICT 0.5294117647058824 0.47058823529411764 0.0 GO:0048589 3 developmental growth 91 95 7 7 7 6 6 6 156 89 2296 0.59941 0.56966 1.0 6.32 29482;85253;25685;294515;24890;114851 slc1a2;plg;igfbp1;foxo3;esr1;cdkn1a SLC1A2_33059;PLG_9501;IGFBP1_32306;FOXO3_8662;ESR1_33192;CDKN1A_8271 29.330195000000003 18.36035 6.24967 25.261884485171528 30.10800327515287 30.317534152281016 19.077145 13.70916 2.44025 17.199117258956925 19.23222513766908 20.41735183384787 58.025483333333334 32.33685 19.0606 51.93493031189766 63.65856255697611 63.103809113850595 3.5 36.21155 13.3235;70.7857;49.0259;13.1992;23.3972;6.24967 9.10952;46.2356;32.6883;5.6804;18.3088;2.44025 24.6773;150.579;89.1623;32.7581;31.9156;19.0606 0 6 0 6 29482;85253;25685;294515;24890;114851 SLC1A2_33059;PLG_9501;IGFBP1_32306;FOXO3_8662;ESR1_33192;CDKN1A_8271 29.330195000000003 18.36035 25.261884485171528 19.077145 13.70916 17.199117258956925 58.025483333333334 32.33685 51.93493031189766 13.3235;70.7857;49.0259;13.1992;23.3972;6.24967 9.10952;46.2356;32.6883;5.6804;18.3088;2.44025 24.6773;150.579;89.1623;32.7581;31.9156;19.0606 0 Exp 2,2(0.34);Exp 4,2(0.34);Linear,1(0.17);Poly 2,1(0.17) 2.04022679568539 13.049423694610596 1.522104263305664 3.9562058448791504 0.9414891361264 1.8043291568756104 9.116477536264949 49.543912463735055 5.31498497182489 32.839305028175104 16.46888416355685 99.58208250310982 DOWN 0.0 1.0 0.0 GO:0043200 5 response to amino acid 78 82 10 10 7 9 6 6 156 76 2309 0.73626 0.42344 0.64561 7.32 29482;83516;25513;497840;81718;25698 slc1a2;ppargc1a;pik3r1;cps1;cdo1;ass1 SLC1A2_33059;PPARGC1A_33189;PIK3R1_32562;CPS1_32421;CDO1_8275;ASS1_33159 26.035899999999998 24.88375 13.3235 10.280352955030294 26.473847586164936 10.073276101274926 18.50982 19.74845 9.10952 6.8937048682983235 19.082691760411276 6.5707591295170795 43.386783333333334 39.152950000000004 24.6773 20.25669216396564 42.827515459495636 20.566395040232475 3.5 29.39315 13.3235;42.4094;18.7324;31.9826;22.9638;26.8037 9.10952;26.2988;11.6701;24.4836;18.5144;20.9825 24.6773;81.7305;41.5978;45.5891;30.0179;36.7081 0 6 0 6 29482;83516;25513;497840;81718;25698 SLC1A2_33059;PPARGC1A_33189;PIK3R1_32562;CPS1_32421;CDO1_8275;ASS1_33159 26.035899999999998 24.88375 10.280352955030294 18.50982 19.74845 6.8937048682983235 43.386783333333334 39.152950000000004 20.25669216396564 13.3235;42.4094;18.7324;31.9826;22.9638;26.8037 9.10952;26.2988;11.6701;24.4836;18.5144;20.9825 24.6773;81.7305;41.5978;45.5891;30.0179;36.7081 0 Exp 2,3(0.5);Linear,1(0.17);Poly 2,2(0.34) 1.7900891465802924 10.768397331237793 1.620316982269287 2.008971929550171 0.14205517928189834 1.7920492887496948 17.80990442225777 34.26189557774222 12.99370727420741 24.025932725792593 27.178053838405592 59.595512828261064 DOWN 0.0 1.0 0.0 GO:0010605 6 negative regulation of macromolecule metabolic process 531 562 56 56 47 51 43 43 119 519 1866 0.9332 0.094752 0.17009 7.65 79426;24522;246273;29573;293615;79224;24794;24648;25106;252922;83516;29441;25513;25591;299282;288001;24516;54404;50693;306251;24471;25675;299626;25112;294515;25661;83928;24360;308441;24890;116636;24330;116663;140942;113936;25695;114851;29184;79431;155423;25377;25373;25303 zfp36;zfp354a;trib3;slc37a4;sirt3;serpind1;serpina3c;serpina1;rgn;pzp;ppargc1a;por;pik3r1;parp1;loc299282;kng1;jun;itih4;itih3;itih1;hspb1;hmgcr;gadd45b;gadd45a;foxo3;fn1;fetub;fabp1;exosc5;esr1;eif4ebp1;egr1;dusp6;ddit4;cpb2;cebpd;cdkn1a;cd36;bhlhe40;anxa7;ambp;ahsg;abcc2 ZFP36_10204;ZFP354A_10203;TRIB3_10079;SLC37A4_9871;SIRT3_9828;SERPIND1_9812;SERPINA3C_32925;SERPINA1_9807;RGN_9699;PZP_9633;PPARGC1A_33189;POR_9531;PIK3R1_32562;PARP1_9425;LOC299282_9119;KNG1L1_34113;JUN_8938;ITIH4_32725;ITIH3_32422;ITIH1_33132;HSPB1_8847;HMGCR_8810;GADD45B_8679;GADD45A_8678;FOXO3_8662;FN1_8655;FETUB_33027;FABP1_33091;EXOSC5_32543;ESR1_33192;EIF4EBP1_8550;EGR1_8533;DUSP6_8506;DDIT4_8450;CPB2_8369;CEBPD_8283;CDKN1A_8271;CD36_8243;BHLHE40_8141;ANXA7_8051;AMBP_33085;AHSG_8003;ABCC2_32541 41.01571288372093 32.5155 0.306936 33.1581477373392 44.075041446034774 33.87806933095229 26.831792841860466 22.6911 0.0732342 21.362307275305895 28.6078469663586 22.868387540936833 62.94479139534882 48.5666 1.15962 49.01793000869501 65.69621950877227 44.20669455898052 27.5 45.71665 0.348134;0.834827;108.064;39.7166;2.38018;28.261;29.766;15.797;77.4407;34.1871;42.4094;12.4414;18.7324;26.9741;45.2017;24.3655;16.4324;57.1163;27.1247;98.1741;89.1011;1.63089;106.367;102.919;13.1992;59.5777;32.5155;33.8478;41.9329;23.3972;83.9001;0.750017;62.3934;87.5421;25.8316;0.306936;6.24967;48.1296;57.8085;104.64;17.2343;12.402;46.2316 0.118102;0.27095;83.8836;22.6911;0.56209;22.307;23.347;13.013;58.7732;26.3085;26.2988;8.48981;11.6701;21.799;30.7472;19.538;10.5224;39.6402;21.5108;42.9071;60.3265;0.663137;52.7132;89.5012;5.6804;31.0499;19.6094;26.4736;31.7336;18.3088;42.4185;0.186019;39.0875;53.2453;20.4374;0.0732342;2.44025;37.5433;38.3491;43.9254;14.1233;10.3013;31.1788 1.15962;2.99857;143.428;60.0334;8.82917;38.3264;40.8256;19.9134;89.8047;48.5666;81.7305;79.2355;41.5978;35.2797;78.6415;32.1467;39.929;101.869;36.4819;104.278;106.138;7.6286;109.434;115.437;32.7581;105.243;49.9875;46.9257;62.1373;31.9156;107.32;4.70178;133.304;245.492;34.8042;1.73689;19.0606;69.1421;110.58;108.689;21.9073;15.4235;81.7848 9 34 9 293615;25106;25591;299626;24360;308441;116636;29184;155423 SIRT3_9828;RGN_9699;PARP1_9425;GADD45B_8679;FABP1_33091;EXOSC5_32543;EIF4EBP1_8550;CD36_8243;ANXA7_8051 58.40137555555556 48.1296 36.32670931202519 35.104654444444435 37.5433 17.548483246043755 70.84018555555555 69.1421 36.00848068918805 2.38018;77.4407;26.9741;106.367;33.8478;41.9329;83.9001;48.1296;104.64 0.56209;58.7732;21.799;52.7132;26.4736;31.7336;42.4185;37.5433;43.9254 8.82917;89.8047;35.2797;109.434;46.9257;62.1373;107.32;69.1421;108.689 34 79426;24522;246273;29573;79224;24794;24648;252922;83516;29441;25513;299282;288001;24516;54404;50693;306251;24471;25675;25112;294515;25661;83928;24890;24330;116663;140942;113936;25695;114851;79431;25377;25373;25303 ZFP36_10204;ZFP354A_10203;TRIB3_10079;SLC37A4_9871;SERPIND1_9812;SERPINA3C_32925;SERPINA1_9807;PZP_9633;PPARGC1A_33189;POR_9531;PIK3R1_32562;LOC299282_9119;KNG1L1_34113;JUN_8938;ITIH4_32725;ITIH3_32422;ITIH1_33132;HSPB1_8847;HMGCR_8810;GADD45A_8678;FOXO3_8662;FN1_8655;FETUB_33027;ESR1_33192;EGR1_8533;DUSP6_8506;DDIT4_8450;CPB2_8369;CEBPD_8283;CDKN1A_8271;BHLHE40_8141;AMBP_33085;AHSG_8003;ABCC2_32541 36.41362570588236 27.69285 31.22739331919001 24.641917711764705 20.9741 21.966929799253304 60.85483411764705 41.2117 52.174934013387514 0.348134;0.834827;108.064;39.7166;28.261;29.766;15.797;34.1871;42.4094;12.4414;18.7324;45.2017;24.3655;16.4324;57.1163;27.1247;98.1741;89.1011;1.63089;102.919;13.1992;59.5777;32.5155;23.3972;0.750017;62.3934;87.5421;25.8316;0.306936;6.24967;57.8085;17.2343;12.402;46.2316 0.118102;0.27095;83.8836;22.6911;22.307;23.347;13.013;26.3085;26.2988;8.48981;11.6701;30.7472;19.538;10.5224;39.6402;21.5108;42.9071;60.3265;0.663137;89.5012;5.6804;31.0499;19.6094;18.3088;0.186019;39.0875;53.2453;20.4374;0.0732342;2.44025;38.3491;14.1233;10.3013;31.1788 1.15962;2.99857;143.428;60.0334;38.3264;40.8256;19.9134;48.5666;81.7305;79.2355;41.5978;78.6415;32.1467;39.929;101.869;36.4819;104.278;106.138;7.6286;115.437;32.7581;105.243;49.9875;31.9156;4.70178;133.304;245.492;34.8042;1.73689;19.0606;110.58;21.9073;15.4235;81.7848 0 Exp 2,14(0.33);Exp 3,3(0.07);Exp 4,3(0.07);Hill,5(0.12);Linear,7(0.17);Poly 2,9(0.21);Power,2(0.05) 1.8943160627622224 84.69896197319031 1.5197933912277222 4.591650485992432 0.6697058538311276 1.7037216424942017 31.104835439070754 50.926590328371105 20.446659057620163 33.21692662610076 48.29346947124907 77.59611331944856 DOWN 0.20930232558139536 0.7906976744186046 0.0 GO:0042737 5 drug catabolic process 55 60 10 10 8 7 5 5 157 55 2330 0.82131 0.33345 0.42916 8.33 360268;29441;65210;24894;296925 sult1e1;por;cyp2j4;cyp2a1;aass SULT1E1_32446;POR_9531;CYP2J4_32580;CYP2A1_32717;AASS_7936 32.66472 27.4644 12.4414 19.231262796732832 28.564088159193073 17.760968348362326 24.027002000000003 21.7498 8.48981 13.29206728199267 21.309125655447136 12.40014666745427 63.34312 79.2355 22.6149 31.772444440458145 57.00892464276578 31.689084066590027 2.0 27.4644 50.1846;12.4414;17.8395;55.3937;27.4644 36.5009;8.48981;14.6501;38.7444;21.7498 80.9788;79.2355;22.6149;96.8569;37.0295 4 1 4 360268;65210;24894;296925 SULT1E1_32446;CYP2J4_32580;CYP2A1_32717;AASS_7936 37.72055 38.8245 17.964200838055667 27.9113 29.12535 11.618387602704024 59.370025 59.00415 35.224249342876945 50.1846;17.8395;55.3937;27.4644 36.5009;14.6501;38.7444;21.7498 80.9788;22.6149;96.8569;37.0295 1 29441 POR_9531 12.4414 12.4414 8.48981 8.48981 79.2355 79.2355 12.4414 8.48981 79.2355 0 Exp 2,1(0.2);Linear,3(0.6);Poly 2,1(0.2) 2.1155268197171986 11.131630182266235 1.672747254371643 3.8079800605773926 0.8934033660275656 1.9288111925125122 15.807774924590337 49.52166507540967 12.375991326417703 35.678012673582295 35.49334453256172 91.19289546743828 UP 0.8 0.2 0.0 GO:0050657 7 nucleic acid transport 18 20 3 3 2 3 2 2 160 18 2367 0.86982 0.36669 0.36669 10.0 79426;297784 zfp36;rrs1 ZFP36_10204;RRS1_9755 30.369067 30.369067 0.348134 42.456010603694004 39.19062395795611 40.581684317633375 21.613551 21.613551 0.118102 30.399155505099188 27.92992123707228 29.057109103963814 53.05081 53.05081 1.15962 73.38522466567912 68.29887334970078 70.14545122386212 0.0 0.348134 1.0 60.39 0.348134;60.39 0.118102;43.109 1.15962;104.942 1 1 1 297784 RRS1_9755 60.39 60.39 43.109 43.109 104.942 104.942 60.39 43.109 104.942 1 79426 ZFP36_10204 0.348134 0.348134 0.118102 0.118102 1.15962 1.15962 0.348134 0.118102 1.15962 0 Exp 2,1(0.5);Hill,1(0.5) 2.103052592075071 4.220130801200867 1.9381765127182007 2.281954288482666 0.2430875964642818 2.1100654006004333 -28.471961679999993 89.21009568 -20.51752904 63.74463104 -48.65592239999997 154.75754239999995 CONFLICT 0.5 0.5 0.0 GO:0030258 5 lipid modification 64 70 29 29 20 28 19 19 143 51 2334 1.0 2.4595E-8 2.4595E-8 27.14 65192;246074;83516;29441;25513;171155;113965;85255;295143;65030;171142;291075;29740;83842;29184;50681;24158;25287;170465 slc27a2;scd;ppargc1a;por;pik3r1;hadhb;hadh;hacl1;etfdh;ephx2;ehhadh;eci2;eci1;crot;cd36;acox1;acadm;acadl;acaa2 SLC27A2_9860;SCD1_9787;PPARGC1A_33189;POR_9531;PIK3R1_32562;HADHB_8777;HADH_8776;HACL1_8775;ETFDH_8575;EPHX2_33282;EHHADH_8534;ECI2_8521;ECI1_8520;CROT_8384;CD36_8243;ACOX1_7973;ACADM_7957;ACADL_32776;ACAA2_7955 26.737593684210527 18.7324 7.4229 22.81175838657365 26.530399383996553 21.649697647603414 19.031897894736844 14.869 5.49916 14.44325245458568 19.17215603693915 14.072346163105243 57.91336842105263 37.6534 10.316 91.0765906083937 54.9786416007666 81.2373625125851 2.5 9.637395 6.0 12.4414 7.62189;105.46;42.4094;12.4414;18.7324;31.8029;33.3125;17.6275;18.1231;38.7293;8.62809;10.6467;11.9473;7.4229;48.1296;23.1906;11.7137;33.4878;26.5872 5.49916;63.7532;26.2988;8.48981;11.6701;25.5756;25.7336;11.195;14.869;29.2097;7.31865;8.92359;7.15307;5.75707;37.5433;16.2815;8.36151;26.6039;21.3695 13.3925;422.699;81.7305;79.2355;41.5978;42.1484;46.9856;37.6534;23.0103;57.2113;10.3909;13.0581;19.001;10.316;69.1421;33.4539;18.9642;45.3228;35.0407 16 3 16 65192;246074;171155;113965;85255;295143;65030;171142;291075;29740;83842;29184;50681;24158;25287;170465 SLC27A2_9860;SCD1_9787;HADHB_8777;HADH_8776;HACL1_8775;ETFDH_8575;EPHX2_33282;EHHADH_8534;ECI2_8521;ECI1_8520;CROT_8384;CD36_8243;ACOX1_7973;ACADM_7957;ACADL_32776;ACAA2_7955 27.151942499999997 20.65685 24.289856621420256 19.696709375 15.57525 15.33997958691535 56.111887499999995 34.247299999999996 99.32069413857234 7.62189;105.46;31.8029;33.3125;17.6275;18.1231;38.7293;8.62809;10.6467;11.9473;7.4229;48.1296;23.1906;11.7137;33.4878;26.5872 5.49916;63.7532;25.5756;25.7336;11.195;14.869;29.2097;7.31865;8.92359;7.15307;5.75707;37.5433;16.2815;8.36151;26.6039;21.3695 13.3925;422.699;42.1484;46.9856;37.6534;23.0103;57.2113;10.3909;13.0581;19.001;10.316;69.1421;33.4539;18.9642;45.3228;35.0407 3 83516;29441;25513 PPARGC1A_33189;POR_9531;PIK3R1_32562 24.527733333333334 18.7324 15.802204666860035 15.486236666666665 11.6701 9.498010607439507 67.52126666666668 79.2355 22.485013881768744 42.4094;12.4414;18.7324 26.2988;8.48981;11.6701 81.7305;79.2355;41.5978 0 Exp 2,7(0.37);Hill,2(0.11);Linear,4(0.22);Poly 2,5(0.27);Power,1(0.06) 3.054359179335009 91.1185257434845 1.6735800504684448 32.73371124267578 7.261152021300938 2.2368218898773193 16.48017615358841 36.99501121483265 12.537419546497572 25.526376242976113 16.960338790260053 98.86639805184521 UP 0.8421052631578947 0.15789473684210525 0.0 GO:0033273 5 response to vitamin 73 78 8 8 5 6 4 4 158 74 2311 0.43918 0.74293 0.81581 5.13 24522;24464;304929;312382 zfp354a;hp;f5;abcg2 ZFP354A_10203;HP_8823;F5_33079;ABCG2_32656 20.39719175 7.91272 0.834827 29.95544676129566 20.772643791803105 31.99856829983984 11.801555 2.662485 0.27095 19.90453439568398 12.757648838472887 20.850379043654147 47.0868425 24.4469 2.99857 61.364353271818636 45.241595976395246 66.4979723677361 2.5 37.7687 0.834827;64.9285;10.6089;5.21654 0.27095;41.6103;2.59129;2.73368 2.99857;136.455;37.5078;11.386 1 3 1 312382 ABCG2_32656 5.21654 5.21654 2.73368 2.73368 11.386 11.386 5.21654 2.73368 11.386 3 24522;24464;304929 ZFP354A_10203;HP_8823;F5_33079 25.457409 10.6089 34.530542919277174 14.82418 2.59129 23.226453946302264 58.98712333333334 37.5078 69.2724741526505 0.834827;64.9285;10.6089 0.27095;41.6103;2.59129 2.99857;136.455;37.5078 0 Exp 2,1(0.25);Exp 4,1(0.25);Hill,2(0.5) 2.095182626656823 9.436938643455505 1.5074360370635986 4.591650485992432 1.4905016886554225 1.6689260601997375 -8.95914607606975 49.753529576069745 -7.704888707770301 31.307998707770302 -13.050223706382262 107.22390870638228 DOWN 0.25 0.75 0.0 GO:0046483 4 heterocycle metabolic process 413 462 60 59 41 53 36 36 126 426 1959 0.9303 0.10074 0.17072 7.79 79426;24856;360268;297784;298490;303612;24651;81819;25591;294103;100359982;24516;364070;63868;25675;24443;499914;294515;314322;308441;24890;65030;25315;24330;24894;25146;83842;497840;25028;192272;170570;50559;170465;312382;25303;296925 zfp36;ttr;sult1e1;rrs1;ppcs;polg2;pklr;pax8;parp1;papss2;mpc2;jun;iars2;hspd1;hmgcr;hdc;gins1;foxo3;fos;exosc5;esr1;ephx2;ephx1;egr1;cyp2a1;cyp17a1;crot;cps1;ampd1;acot2;acot12;acot1;acaa2;abcg2;abcc2;aass ZFP36_10204;TTR_10102;SULT1E1_32446;RRS1_9755;PPCS_9540;POLG2_9521;PKLR_9489;PAX8_9432;PARP1_9425;PAPSS2_33237;MPC2_33219;JUN_8938;IARS2_8858;HSPD1_8849;HMGCR_8810;HDC_8788;GINS1_8707;FOXO3_8662;FOS_8657;EXOSC5_32543;ESR1_33192;EPHX2_33282;EPHX1_8567;EGR1_8533;CYP2A1_32717;CYP17A1_32365;CROT_8384;CPS1_32421;AMPD1_32743;ACOT2_7969;ACOT12_32718;ACOT1_7968;ACAA2_7955;ABCG2_32656;ABCC2_32541;AASS_7936 30.831756416666696 28.903350000000003 1.28141E-12 19.477844072548827 33.392233056385564 18.986947086658816 22.628817166666707 22.87295 1.28141E-12 14.40504266468761 24.69268955605242 14.337476257618517 49.06450000000004 38.60045 1.28142E-12 33.61449391407253 52.200465113953555 32.35715948033022 22.5 40.3311 0.348134;46.6406;50.1846;60.39;20.3353;63.7758;23.0963;56.8931;26.9741;34.4443;46.8463;16.4324;24.7304;42.2579;1.63089;24.5745;58.9165;13.1992;1.28141E-12;41.9329;23.3972;38.7293;12.4747;0.750017;55.3937;49.6922;7.4229;31.9826;60.9045;8.54905;30.3423;31.2018;26.5872;5.21654;46.2316;27.4644 0.118102;28.5876;36.5009;43.109;16.7643;40.9553;17.4625;45.1162;21.799;25.719;35.8494;10.5224;19.8021;23.9469;0.663137;21.0619;44.7208;5.6804;1.28141E-12;31.7336;18.3088;29.2097;7.00435;0.186019;38.7444;35.6654;5.75707;24.4836;50.0633;7.19676;24.0157;26.858;21.3695;2.73368;31.1788;21.7498 1.15962;63.7146;80.9788;104.942;25.6711;132.567;32.9443;81.5688;35.2797;51.1014;69.127;39.929;32.7087;102.383;7.6286;29.28;91.837;32.7581;1.28142E-12;62.1373;31.9156;57.2113;23.684;4.70178;96.8569;81.6409;10.316;45.5891;82.6625;10.4125;41.1025;37.2719;35.0407;11.386;81.7848;37.0295 24 12 24 24856;360268;297784;298490;81819;25591;100359982;364070;63868;24443;499914;308441;65030;25315;24894;25146;83842;25028;192272;170570;50559;170465;312382;296925 TTR_10102;SULT1E1_32446;RRS1_9755;PPCS_9540;PAX8_9432;PARP1_9425;MPC2_33219;IARS2_8858;HSPD1_8849;HDC_8788;GINS1_8707;EXOSC5_32543;EPHX2_33282;EPHX1_8567;CYP2A1_32717;CYP17A1_32365;CROT_8384;AMPD1_32743;ACOT2_7969;ACOT12_32718;ACOT1_7968;ACAA2_7955;ABCG2_32656;AASS_7936 35.61061625 34.96555 17.597894754597853 26.639973333333334 25.43685 13.138813683626763 54.343445833333334 49.1569 30.594742793322308 46.6406;50.1846;60.39;20.3353;56.8931;26.9741;46.8463;24.7304;42.2579;24.5745;58.9165;41.9329;38.7293;12.4747;55.3937;49.6922;7.4229;60.9045;8.54905;30.3423;31.2018;26.5872;5.21654;27.4644 28.5876;36.5009;43.109;16.7643;45.1162;21.799;35.8494;19.8021;23.9469;21.0619;44.7208;31.7336;29.2097;7.00435;38.7444;35.6654;5.75707;50.0633;7.19676;24.0157;26.858;21.3695;2.73368;21.7498 63.7146;80.9788;104.942;25.6711;81.5688;35.2797;69.127;32.7087;102.383;29.28;91.837;62.1373;57.2113;23.684;96.8569;81.6409;10.316;82.6625;10.4125;41.1025;37.2719;35.0407;11.386;37.0295 12 79426;303612;24651;294103;24516;25675;294515;314322;24890;24330;497840;25303 ZFP36_10204;POLG2_9521;PKLR_9489;PAPSS2_33237;JUN_8938;HMGCR_8810;FOXO3_8662;FOS_8657;ESR1_33192;EGR1_8533;CPS1_32421;ABCC2_32541 21.274036750000107 19.76435 20.251708234728078 14.606504833333439 13.992449999999998 13.927719932100146 38.50660833333344 32.8512 38.15324729525519 0.348134;63.7758;23.0963;34.4443;16.4324;1.63089;13.1992;1.28141E-12;23.3972;0.750017;31.9826;46.2316 0.118102;40.9553;17.4625;25.719;10.5224;0.663137;5.6804;1.28141E-12;18.3088;0.186019;24.4836;31.1788 1.15962;132.567;32.9443;51.1014;39.929;7.6286;32.7581;1.28142E-12;31.9156;4.70178;45.5891;81.7848 0 Exp 2,19(0.53);Exp 3,1(0.03);Exp 4,3(0.09);Hill,4(0.12);Linear,6(0.17);Poly 2,3(0.09) 2.683595753138937 446.75407099723816 1.5074360370635986 344.14306640625 56.953400970325234 1.9236147999763489 24.46899401963409 37.19451881369932 17.92316989620208 27.33446443713132 38.083765321403 60.04523467859706 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0031667 5 response to nutrient levels 239 256 43 43 33 37 28 28 134 228 2157 0.99891 0.0023088 0.002851 10.94 79426;24522;29573;83516;29441;24651;25513;24314;24539;24516;63868;24464;25675;24957;24384;294515;304929;116636;24330;25146;497840;114851;29184;246142;25698;192272;24158;312382 zfp36;zfp354a;slc37a4;ppargc1a;por;pklr;pik3r1;nqo1;lpl;jun;hspd1;hp;hmgcr;glul;gc;foxo3;f5;eif4ebp1;egr1;cyp17a1;cps1;cdkn1a;cd36;bmf;ass1;acot2;acadm;abcg2 ZFP36_10204;ZFP354A_10203;SLC37A4_9871;PPARGC1A_33189;POR_9531;PKLR_9489;PIK3R1_32562;NQO1_33055;LPL_32544;JUN_8938;HSPD1_8849;HP_8823;HMGCR_8810;GLUL_32832;GC_32893;FOXO3_8662;F5_33079;EIF4EBP1_8550;EGR1_8533;CYP17A1_32365;CPS1_32421;CDKN1A_8271;CD36_8243;BMF_8152;ASS1_33159;ACOT2_7969;ACADM_7957;ABCG2_32656 31.600151 24.781599999999997 0.348134 28.205505774417485 35.49109338189187 29.366488404404226 20.89809671428571 19.2225 0.118102 19.493922893260994 23.623129426216718 20.576579399975287 58.49518107142857 40.763400000000004 1.15962 49.712091482861176 62.706062318988145 47.247287526913425 11.5 17.5824 24.5 79.0521 0.348134;0.834827;39.7166;42.4094;12.4414;23.0963;18.7324;87.2765;74.2041;16.4324;42.2579;64.9285;1.63089;26.4669;42.356;13.1992;10.6089;83.9001;0.750017;49.6922;31.9826;6.24967;48.1296;94.8767;26.8037;8.54905;11.7137;5.21654 0.118102;0.27095;22.6911;26.2988;8.48981;17.4625;11.6701;60.6992;49.8682;10.5224;23.9469;41.6103;0.663137;21.0456;26.3722;5.6804;2.59129;42.4185;0.186019;35.6654;24.4836;2.44025;37.5433;73.1342;20.9825;7.19676;8.36151;2.73368 1.15962;2.99857;60.0334;81.7305;79.2355;32.9443;41.5978;197.117;155.425;39.929;102.383;136.455;7.6286;35.4303;78.7583;32.7581;37.5078;107.32;4.70178;81.6409;45.5891;19.0606;69.1421;109.848;36.7081;10.4125;18.9642;11.386 10 18 10 24314;24539;63868;116636;25146;29184;246142;192272;24158;312382 NQO1_33055;LPL_32544;HSPD1_8849;EIF4EBP1_8550;CYP17A1_32365;CD36_8243;BMF_8152;ACOT2_7969;ACADM_7957;ABCG2_32656 50.581638999999996 48.9109 33.97424092075068 34.156765 36.60435 23.656053989290054 86.36386999999999 92.01195 61.94520398648128 87.2765;74.2041;42.2579;83.9001;49.6922;48.1296;94.8767;8.54905;11.7137;5.21654 60.6992;49.8682;23.9469;42.4185;35.6654;37.5433;73.1342;7.19676;8.36151;2.73368 197.117;155.425;102.383;107.32;81.6409;69.1421;109.848;10.4125;18.9642;11.386 18 79426;24522;29573;83516;29441;24651;25513;24516;24464;25675;24957;24384;294515;304929;24330;497840;114851;25698 ZFP36_10204;ZFP354A_10203;SLC37A4_9871;PPARGC1A_33189;POR_9531;PKLR_9489;PIK3R1_32562;JUN_8938;HP_8823;HMGCR_8810;GLUL_32832;GC_32893;FOXO3_8662;F5_33079;EGR1_8533;CPS1_32421;CDKN1A_8271;ASS1_33159 21.054879888888888 17.5824 17.965662278870788 13.532169888888887 11.09625 12.100863215672856 43.012576111111116 37.10795 34.392691730916454 0.348134;0.834827;39.7166;42.4094;12.4414;23.0963;18.7324;16.4324;64.9285;1.63089;26.4669;42.356;13.1992;10.6089;0.750017;31.9826;6.24967;26.8037 0.118102;0.27095;22.6911;26.2988;8.48981;17.4625;11.6701;10.5224;41.6103;0.663137;21.0456;26.3722;5.6804;2.59129;0.186019;24.4836;2.44025;20.9825 1.15962;2.99857;60.0334;81.7305;79.2355;32.9443;41.5978;39.929;136.455;7.6286;35.4303;78.7583;32.7581;37.5078;4.70178;45.5891;19.0606;36.7081 0 Exp 2,8(0.29);Exp 3,3(0.11);Exp 4,4(0.15);Hill,4(0.15);Linear,3(0.11);Poly 2,6(0.22) 2.1010809208712193 67.45805168151855 1.5074360370635986 11.836054801940918 1.9874367432447368 1.8875073790550232 21.152685456533312 42.047616543466695 13.677446626916488 28.118746801654932 40.0815647011126 76.90879744174458 DOWN 0.35714285714285715 0.6428571428571429 0.0 GO:0090181 6 regulation of cholesterol metabolic process 18 18 7 7 5 6 4 4 158 14 2371 0.99574 0.02391 0.02391 22.22 29441;65030;25428;25287 por;ephx2;cyp7a1;acadl POR_9531;EPHX2_33282;CYP7A1_8430;ACADL_32776 22.594945000000003 22.9646 5.72128 15.987356962261353 25.17643802059202 15.013014033070977 16.32217075 17.546855 0.985273 13.764309815025316 18.635394357078503 12.3157636748795 51.033025 51.26705 22.3625 23.721694370537 61.52691884169885 19.336939817221843 0.0 5.72128 0.5 9.08134 12.4414;38.7293;5.72128;33.4878 8.48981;29.2097;0.985273;26.6039 79.2355;57.2113;22.3625;45.3228 2 2 2 65030;25287 EPHX2_33282;ACADL_32776 36.10855 36.10855 3.706300193589283 27.9068 27.9068 1.8425788504159497 51.26705 51.26705 8.406438968136383 38.7293;33.4878 29.2097;26.6039 57.2113;45.3228 2 29441;25428 POR_9531;CYP7A1_8430 9.08134 9.08134 4.7518424223873375 4.7375415 4.7375415 5.306509002365351 50.799 50.799 40.21528396642253 12.4414;5.72128 8.48981;0.985273 79.2355;22.3625 0 Exp 2,1(0.25);Hill,1(0.25);Linear,1(0.25);Poly 2,1(0.25) 2.9831550275642047 13.072446703910828 1.8872262239456177 4.642963409423828 1.54068768151079 3.271128535270691 6.9273351769838705 38.26255482301613 2.833147131275192 29.811194368724813 27.785764516873744 74.28028548312626 CONFLICT 0.5 0.5 0.0 GO:0050731 10 positive regulation of peptidyl-tyrosine phosphorylation 66 72 3 3 2 3 2 2 160 70 2315 0.15196 0.95034 0.32212 2.78 29496;29184 erbb3;cd36 ERBB3_8571;CD36_8243 54.564 54.564 48.1296 9.099615745733429 53.394342105962025 8.948005785750713 39.57345 39.57345 37.5433 2.871065663651677 39.204405337936535 2.823230440436005 91.55705 91.55705 69.1421 31.69952628991479 87.48241627937855 31.17137608593098 60.9984;48.1296 41.6036;37.5433 113.972;69.1421 2 0 2 29496;29184 ERBB3_8571;CD36_8243 54.564 54.564 9.099615745733429 39.57345 39.57345 2.871065663651677 91.55705 91.55705 31.69952628991479 60.9984;48.1296 41.6036;37.5433 113.972;69.1421 0 0 Exp 2,1(0.5);Linear,1(0.5) 2.067843221161839 4.271613359451294 1.6013026237487793 2.6703107357025146 0.7559028851059142 2.135806679725647 41.95257600000001 67.17542399999999 35.594356000000005 43.552544 47.62374800000001 135.490352 UP 1.0 0.0 0.0 GO:0071478 5 cellular response to radiation 59 61 7 7 7 6 6 6 156 55 2330 0.91086 0.18846 0.27917 9.84 25513;25591;25112;24330;114851;246142 pik3r1;parp1;gadd45a;egr1;cdkn1a;bmf PIK3R1_32562;PARP1_9425;GADD45A_8678;EGR1_8533;CDKN1A_8271;BMF_8152 41.7503145 22.85325 0.750017 45.28465961001744 48.09006282711387 47.40740842396079 33.12179483333333 16.73455 0.186019 38.455515368623786 38.52688596069449 40.13001069308751 54.32081333333334 38.43875 4.70178 47.00686526517021 60.00446922506255 49.48258026312061 2.5 22.85325 18.7324;26.9741;102.919;0.750017;6.24967;94.8767 11.6701;21.799;89.5012;0.186019;2.44025;73.1342 41.5978;35.2797;115.437;4.70178;19.0606;109.848 2 4 2 25591;246142 PARP1_9425;BMF_8152 60.925399999999996 60.925399999999996 48.014388920197675 47.4666 47.4666 36.29946803356768 72.56385 72.56385 52.727750591552805 26.9741;94.8767 21.799;73.1342 35.2797;109.848 4 25513;25112;24330;114851 PIK3R1_32562;GADD45A_8678;EGR1_8533;CDKN1A_8271 32.16277175 12.491035 47.7670343954168 25.94939225 7.055175 42.65818259139904 45.199295 30.3292 49.22596221297693 18.7324;102.919;0.750017;6.24967 11.6701;89.5012;0.186019;2.44025 41.5978;115.437;4.70178;19.0606 0 Exp 2,1(0.17);Exp 4,1(0.17);Hill,1(0.17);Poly 2,3(0.5) 1.9442988798891105 12.557780742645264 1.522104263305664 4.21828556060791 1.0453474744318845 1.6873788833618164 5.515040154745968 77.98558884525403 2.3509739533642886 63.892615713302376 16.707487459574395 91.93413920709227 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0017144 4 drug metabolic process 142 165 34 34 22 28 16 16 146 149 2236 0.97035 0.055429 0.095935 9.7 286954;360268;29441;24651;84493;25256;266682;65210;24894;25146;497840;362866;25028;65183;25303;296925 ugt2b1;sult1e1;por;pklr;fmo3;fmo1;cyp3a2;cyp2j4;cyp2a1;cyp17a1;cps1;chpt1;ampd1;aldh3a2;abcc2;aass UGT2B10_33303,UGT2B1_33224;SULT1E1_32446;POR_9531;PKLR_9489;FMO3_8654;FMO1_32787;CYP3A2_32374;CYP2J4_32580;CYP2A1_32717;CYP17A1_32365;CPS1_32421;CHPT1_33298;AMPD1_32743;ALDH3A2_8024;ABCC2_32541;AASS_7936 38.928578125 44.66975 12.4414 18.596299564581557 38.13835779505928 19.503293997220066 27.870982500000004 31.528100000000002 7.33176 13.180067899651347 27.3171986390688 13.890722535725253 65.075159375 77.855125 22.6149 29.143676772610657 64.21915578168581 31.375175360764022 7.5 44.66975 47.47345;50.1846;12.4414;23.0963;62.8595;65.2792;12.8505;17.8395;55.3937;49.6922;31.9826;16.0559;60.9045;43.1079;46.2316;27.4644 34.82915;36.5009;8.48981;17.4625;42.5185;39.7882;7.33176;14.6501;38.7444;35.6654;24.4836;10.6021;50.0633;31.8774;31.1788;21.7498 76.47475;80.9788;79.2355;32.9443;120.21;82.9415;24.0283;22.6149;96.8569;81.6409;45.5891;29.905;82.6625;66.3058;81.7848;37.0295 12 5 11 286954;360268;25256;266682;65210;24894;25146;362866;25028;65183;296925 UGT2B10_33303,UGT2B1_33224;SULT1E1_32446;FMO1_32787;CYP3A2_32374;CYP2J4_32580;CYP2A1_32717;CYP17A1_32365;CHPT1_33298;AMPD1_32743;ALDH3A2_8024;AASS_7936 40.56780454545455 47.47345 18.791690367133754 29.254773636363634 34.82915 13.651802259908603 61.948986363636365 76.47475 27.750908600279114 47.47345;50.1846;65.2792;12.8505;17.8395;55.3937;49.6922;16.0559;60.9045;43.1079;27.4644 34.82915;36.5009;39.7882;7.33176;14.6501;38.7444;35.6654;10.6021;50.0633;31.8774;21.7498 76.47475;80.9788;82.9415;24.0283;22.6149;96.8569;81.6409;29.905;82.6625;66.3058;37.0295 5 29441;24651;84493;497840;25303 POR_9531;PKLR_9489;FMO3_8654;CPS1_32421;ABCC2_32541 35.32228 31.9826 19.757748272690385 24.826642 24.4836 12.986455403181427 71.95273999999999 79.2355 34.26065908973441 12.4414;23.0963;62.8595;31.9826;46.2316 8.48981;17.4625;42.5185;24.4836;31.1788 79.2355;32.9443;120.21;45.5891;81.7848 0 Exp 2,7(0.42);Hill,1(0.06);Linear,6(0.36);Poly 2,3(0.18) 1.9441197493123858 34.238701581954956 1.520427942276001 3.8079800605773926 0.6258491206581288 1.8264755010604858 29.81639133835504 48.04076491164496 21.412749229170835 34.32921577082916 50.79475775642077 79.35556099357922 UP 0.6875 0.3125 0.0 GO:0006952 4 defense response 257 279 23 23 17 21 16 16 146 263 2122 0.38334 0.71352 0.79454 5.73 24825;24648;246074;288001;54404;24464;25661;361969;308441;65030;140942;29184;313421;25698;25373;25303 tf;serpina1;scd;kng1;itih4;hp;fn1;fga;exosc5;ephx2;ddit4;cd36;c8b;ass1;ahsg;abcc2 TF_10003;SERPINA1_9807;SCD1_9787;KNG1L1_34113;ITIH4_32725;HP_8823;FN1_8655;FGA_8632;EXOSC5_32543;EPHX2_33282;DDIT4_8450;CD36_8243;C8B_8181;ASS1_33159;AHSG_8003;ABCC2_32541 45.2570125 43.5434 12.402 25.536133413834722 47.28463930015721 21.41402005515962 30.666806249999997 30.129800000000003 10.3013 14.267795569111524 31.69290840963364 11.918201265533925 94.65790625000001 61.8357 15.4235 104.3539661293329 91.50530761163046 87.18460012339285 12.5 62.2531 45.1539;15.797;105.46;24.3655;57.1163;64.9285;59.5777;28.5803;41.9329;38.7293;87.5421;48.1296;21.3618;26.8037;12.402;46.2316 28.132;13.013;63.7532;19.538;39.6402;41.6103;31.0499;22.529;31.7336;29.2097;53.2453;37.5433;17.2088;20.9825;10.3013;31.1788 61.5341;19.9134;422.699;32.1467;101.869;136.455;105.243;38.8511;62.1373;57.2113;245.492;69.1421;27.9161;36.7081;15.4235;81.7848 5 11 5 24825;246074;308441;65030;29184 TF_10003;SCD1_9787;EXOSC5_32543;EPHX2_33282;CD36_8243 55.88114 45.1539 27.937261962171572 38.07436 31.7336 14.809817732943232 134.54476 62.1373 161.1398730435084 45.1539;105.46;41.9329;38.7293;48.1296 28.132;63.7532;31.7336;29.2097;37.5433 61.5341;422.699;62.1373;57.2113;69.1421 11 24648;288001;54404;24464;25661;361969;140942;313421;25698;25373;25303 SERPINA1_9807;KNG1L1_34113;ITIH4_32725;HP_8823;FN1_8655;FGA_8632;DDIT4_8450;C8B_8181;ASS1_33159;AHSG_8003;ABCC2_32541 40.42786363636364 28.5803 24.16311513498509 27.299736363636363 22.529 13.33101283581054 76.52751818181818 38.8511 69.21805600348537 15.797;24.3655;57.1163;64.9285;59.5777;28.5803;87.5421;21.3618;26.8037;12.402;46.2316 13.013;19.538;39.6402;41.6103;31.0499;22.529;53.2453;17.2088;20.9825;10.3013;31.1788 19.9134;32.1467;101.869;136.455;105.243;38.8511;245.492;27.9161;36.7081;15.4235;81.7848 0 Exp 2,9(0.57);Linear,5(0.32);Poly 2,1(0.07);Power,1(0.07) 2.0045003903845817 33.892131209373474 1.5122476816177368 4.642963409423828 0.8463105117844473 1.806852400302887 32.744307127220985 57.76971787277902 23.675586421135357 37.65802607886465 43.524462846626875 145.79134965337312 DOWN 0.3125 0.6875 0.0 GO:0051053 7 negative regulation of DNA metabolic process 19 19 3 3 3 3 3 3 159 16 2369 0.97118 0.11579 0.11579 15.79 25106;25591;114851 rgn;parp1;cdkn1a RGN_9699;PARP1_9425;CDKN1A_8271 36.88815666666667 26.9741 6.24967 36.61634987007353 30.444010753443408 33.947261235481925 27.670816666666667 21.799 2.44025 28.621827110630683 22.62861856699809 26.75784823520627 48.048333333333325 35.2797 19.0606 37.060226916511645 41.560368594362856 34.06618738872387 0.0 6.24967 0.5 16.611885 77.4407;26.9741;6.24967 58.7732;21.799;2.44025 89.8047;35.2797;19.0606 2 1 2 25106;25591 RGN_9699;PARP1_9425 52.20740000000001 52.20740000000001 35.68527508342902 40.286100000000005 40.286100000000005 26.144707548947647 62.542199999999994 62.542199999999994 38.55499724419652 77.4407;26.9741 58.7732;21.799 89.8047;35.2797 1 114851 CDKN1A_8271 6.24967 6.24967 2.44025 2.44025 19.0606 19.0606 6.24967 2.44025 19.0606 0 Exp 2,1(0.34);Exp 4,1(0.34);Poly 2,1(0.34) 1.6791950811286926 5.050660490989685 1.522104263305664 1.8086696863174438 0.14669697679698518 1.7198865413665771 -4.547143863621123 78.32345719695448 -4.717829723895576 60.05946305722891 6.110738639839184 89.98592802682748 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0007422 5 peripheral nervous system development 5 6 3 3 2 3 2 2 160 4 2381 0.99562 0.050905 0.050905 33.33 29496;65183 erbb3;aldh3a2 ERBB3_8571;ALDH3A2_8024 52.05315 52.05315 43.1079 12.650493868817893 51.89977024483611 12.64863409330868 36.7405 36.7405 31.8774 6.877461975176645 36.65711484169392 6.876450905136166 90.1389 90.1389 66.3058 33.70509325339417 89.73024568147379 33.70013819728188 0.0 43.1079 0.0 43.1079 60.9984;43.1079 41.6036;31.8774 113.972;66.3058 2 0 2 29496;65183 ERBB3_8571;ALDH3A2_8024 52.05315 52.05315 12.650493868817893 36.7405 36.7405 6.877461975176645 90.1389 90.1389 33.70509325339417 60.9984;43.1079 41.6036;31.8774 113.972;66.3058 0 0 Linear,2(1) 1.5603413899488527 3.1217305660247803 1.520427942276001 1.6013026237487793 0.05718703569570359 1.5608652830123901 34.52046000000001 69.58583999999999 27.208824 46.272175999999995 43.42602400000002 136.851776 UP 1.0 0.0 0.0 GO:0051793 7 medium-chain fatty acid catabolic process 1 1 1 1 1 1 1 1 161 0 2385 1.0 0.063604 0.063604 100.0 24158 acadm ACADM_7957 11.7137 11.7137 11.7137 11.7137 8.36151 8.36151 8.36151 8.36151 18.9642 18.9642 18.9642 18.9642 0.0 11.7137 0.0 11.7137 11.7137 8.36151 18.9642 1 0 1 24158 ACADM_7957 11.7137 11.7137 8.36151 8.36151 18.9642 18.9642 11.7137 8.36151 18.9642 0 0 Poly 2,1(1) 1.693061113357544 1.693061113357544 1.693061113357544 1.693061113357544 0.0 1.693061113357544 11.7137 11.7137 8.36151 8.36151 18.9642 18.9642 UP 1.0 0.0 0.0 GO:1990748 3 cellular detoxification 40 50 6 6 6 6 6 6 156 44 2341 0.96359 0.094288 0.13048 12.0 24314;24464;81869;29328;24360;312382 nqo1;hp;gstm7;gpx4;fabp1;abcg2 NQO1_33055;HP_8823;GSTM7_8761;GPX4_32827;FABP1_33091;ABCG2_32656 46.584156666666665 44.1178 5.21654 27.87307228148463 38.79966935234474 25.760246639237963 32.85668 32.81165 2.73368 18.994422605533458 26.9893925323194 17.43956931525907 87.81866666666667 67.51415 11.386 67.3310443603444 70.72208794676808 56.10836915403429 1.5 38.0815 4.0 64.9285 87.2765;64.9285;42.3152;45.9204;33.8478;5.21654 60.6992;41.6103;31.4035;34.2198;26.4736;2.73368 197.117;136.455;64.5991;70.4292;46.9257;11.386 5 1 5 24314;81869;29328;24360;312382 NQO1_33055;GSTM7_8761;GPX4_32827;FABP1_33091;ABCG2_32656 42.915288 42.3152 29.498825710724823 31.105956 31.4035 20.688096908988033 78.0914 64.5991 70.40730815962928 87.2765;42.3152;45.9204;33.8478;5.21654 60.6992;31.4035;34.2198;26.4736;2.73368 197.117;64.5991;70.4292;46.9257;11.386 1 24464 HP_8823 64.9285 64.9285 41.6103 41.6103 136.455 136.455 64.9285 41.6103 136.455 0 Exp 2,4(0.67);Exp 4,1(0.17);Linear,1(0.17) 1.6437512353154178 9.891073942184448 1.5074360370635986 1.8753424882888794 0.1394307553611437 1.6051767468452454 24.281053813238767 68.88725952009456 17.65797650816792 48.055383491832075 33.94261050636268 141.69472282697063 UP 0.8333333333333334 0.16666666666666666 0.0 GO:0043618 8 regulation of transcription from RNA polymerase II promoter in response to stress 23 25 3 3 3 2 2 2 160 23 2362 0.79018 0.47902 0.67089 8.0 24516;24330 jun;egr1 JUN_8938;EGR1_8533 8.5912085 8.5912085 0.750017 11.089119364464633 6.395738332895003 10.64558076245953 5.3542095 5.3542095 0.186019 7.308925098027787 3.907157982298199 7.016585344654074 22.31539 22.31539 4.70178 24.909406144350374 17.38372173376492 23.913088689833017 0.5 8.5912085 16.4324;0.750017 10.5224;0.186019 39.929;4.70178 0 2 0 2 24516;24330 JUN_8938;EGR1_8533 8.5912085 8.5912085 11.089119364464633 5.3542095 5.3542095 7.308925098027787 22.31539 22.31539 24.909406144350374 16.4324;0.750017 10.5224;0.186019 39.929;4.70178 0 Hill,1(0.5);Poly 2,1(0.5) 2.8889275965228003 6.196791410446167 1.9785058498382568 4.21828556060791 1.583763421849266 3.0983957052230835 -6.77752684 23.95994384 -4.775443879999999 15.483862879999998 -12.207285599999999 56.8380656 DOWN 0.0 1.0 0.0 GO:0008202 5 steroid metabolic process 95 104 33 33 25 24 19 19 143 85 2300 1.0 1.7341E-5 1.7341E-5 18.27 293688;361510;360268;29573;65192;29500;246074;501907;83516;29540;289456;25675;24384;246186;24890;25428;266682;25146;25284 tm7sf2;sult2a2;sult1e1;slc37a4;slc27a2;slc10a2;scd;rgd1559459;ppargc1a;hsd17b7;hsd17b11;hmgcr;gc;fgl1;esr1;cyp7a1;cyp3a2;cyp17a1;amacr TM7SF2_10031;SULT2A2_33196;SULT1E1_32446;SLC37A4_9871;SLC27A2_9860;SLC10A2_9833;SCD1_9787;RGD1559459_9690;PPARGC1A_33189;HSD17B7_8834;HSD17B11_8832;HMGCR_8810;GC_32893;FGL1_8640;ESR1_33192;CYP7A1_8430;CYP3A2_32374;CYP17A1_32365;AMACR_8038 32.371199684210545 23.3972 2.52378E-13 29.66215762504532 32.38138227697146 26.63730047176116 20.836584842105275 18.3088 2.52378E-13 18.713402939884865 20.828897742435245 16.57939807777421 73.88514894736844 31.9156 2.52379E-13 99.20050494471481 70.12663143411619 89.7807759037397 4.5 6.671585 9.5 31.5569 82.3097;54.1932;50.1846;39.7166;7.62189;56.585;105.46;2.52378E-13;42.4094;0.977494;22.4334;1.63089;42.356;15.4757;23.3972;5.72128;12.8505;49.6922;2.03774 51.1696;35.5514;36.5009;22.6911;5.49916;35.2796;63.7532;2.52378E-13;26.2988;0.322682;18.1233;0.663137;26.3722;10.2138;18.3088;0.985273;7.33176;35.6654;1.165 209.842;103.141;80.9788;60.0334;13.3925;116.8;422.699;2.52379E-13;81.7305;5.49472;29.2247;7.6286;78.7583;30.4106;31.9156;22.3625;24.0283;81.6409;3.73641 7 12 7 360268;65192;246074;289456;266682;25146;25284 SULT1E1_32446;SLC27A2_9860;SCD1_9787;HSD17B11_8832;CYP3A2_32374;CYP17A1_32365;AMACR_8038 35.754332857142856 22.4334 36.266726184557804 24.005531428571427 18.1233 22.541646225473 93.67151571428573 29.2247 148.38100693635872 50.1846;7.62189;105.46;22.4334;12.8505;49.6922;2.03774 36.5009;5.49916;63.7532;18.1233;7.33176;35.6654;1.165 80.9788;13.3925;422.699;29.2247;24.0283;81.6409;3.73641 12 293688;361510;29573;29500;501907;83516;29540;25675;24384;246186;24890;25428 TM7SF2_10031;SULT2A2_33196;SLC37A4_9871;SLC10A2_9833;RGD1559459_9690;PPARGC1A_33189;HSD17B7_8834;HMGCR_8810;GC_32893;FGL1_8640;ESR1_33192;CYP7A1_8430 30.397705333333352 31.5569 26.660622734908948 18.988032666666687 20.49995 16.904517702468034 62.34310166666668 45.9745 60.82213675393968 82.3097;54.1932;39.7166;56.585;2.52378E-13;42.4094;0.977494;1.63089;42.356;15.4757;23.3972;5.72128 51.1696;35.5514;22.6911;35.2796;2.52378E-13;26.2988;0.322682;0.663137;26.3722;10.2138;18.3088;0.985273 209.842;103.141;60.0334;116.8;2.52379E-13;81.7305;5.49472;7.6286;78.7583;30.4106;31.9156;22.3625 0 Exp 2,6(0.32);Exp 3,1(0.06);Exp 4,3(0.16);Hill,4(0.22);Linear,3(0.16);Poly 2,2(0.11) 2.0270613581737993 40.53419518470764 1.511321783065796 4.560328960418701 0.8075822138264047 1.893584966659546 19.03346699113179 45.70893237728927 12.422012667513618 29.251157016696936 29.279161928613235 118.49113596612361 DOWN 0.3684210526315789 0.631578947368421 0.0 GO:0022613 5 ribonucleoprotein complex biogenesis 12 15 2 2 2 2 2 2 160 13 2372 0.93468 0.24652 0.24652 13.33 297784;24957 rrs1;glul RRS1_9755;GLUL_32832 43.42845 43.42845 26.4669 23.987254048869364 43.255230743044955 23.98600314731573 32.0773 32.0773 21.0456 15.60117975603128 31.964639136048834 15.600366176454548 70.18615 70.18615 35.4303 49.152194441804944 69.83120705481863 49.14963122401154 0.0 26.4669 0.5 43.42845 60.39;26.4669 43.109;21.0456 104.942;35.4303 1 1 1 297784 RRS1_9755 60.39 60.39 43.109 43.109 104.942 104.942 60.39 43.109 104.942 1 24957 GLUL_32832 26.4669 26.4669 21.0456 21.0456 35.4303 35.4303 26.4669 21.0456 35.4303 0 Exp 2,1(0.5);Linear,1(0.5) 2.3217629453875963 4.644220352172852 2.281954288482666 2.3622660636901855 0.0567890008583667 2.322110176086426 10.183811999999996 76.673088 10.455168000000004 53.699432 2.064684000000014 138.307616 CONFLICT 0.5 0.5 0.0 GO:0060688 5 regulation of morphogenesis of a branching structure 18 20 4 4 2 4 2 2 160 18 2367 0.86982 0.36669 0.36669 10.0 81819;24890 pax8;esr1 PAX8_9432;ESR1_33192 40.14515 40.14515 23.3972 23.685178031946474 51.11724762575452 17.89451887553349 31.7125 31.7125 18.3088 18.95569432598026 40.49367649899396 14.321320678171865 56.7422 56.7422 31.9156 35.11011442761188 73.00686993963781 26.526235289412764 0.0 23.3972 1.0 56.8931 56.8931;23.3972 45.1162;18.3088 81.5688;31.9156 1 1 1 81819 PAX8_9432 56.8931 56.8931 45.1162 45.1162 81.5688 81.5688 56.8931 45.1162 81.5688 1 24890 ESR1_33192 23.3972 23.3972 18.3088 18.3088 31.9156 31.9156 23.3972 18.3088 31.9156 0 Exp 2,2(1) 2.0664177489136324 4.189184188842773 1.7521979808807373 2.436986207962036 0.4842183990458998 2.0945920944213867 7.319168000000012 72.97113199999998 5.441248000000002 57.983751999999996 8.082063999999995 105.40233599999999 CONFLICT 0.5 0.5 0.0 GO:0007595 6 lactation 22 23 5 5 4 3 2 2 160 21 2364 0.82335 0.43545 0.65454 8.7 24384;81718 gc;cdo1 GC_32893;CDO1_8275 32.6599 32.6599 22.9638 13.712356122125772 32.95330146753247 13.70607681204581 22.4433 22.4433 18.5144 5.556303665207645 22.562187493506496 5.553759262677417 54.3881 54.3881 30.0179 34.46466735774481 55.12553592207792 34.44888492537398 0.5 32.6599 42.356;22.9638 26.3722;18.5144 78.7583;30.0179 0 2 0 2 24384;81718 GC_32893;CDO1_8275 32.6599 32.6599 13.712356122125772 22.4433 22.4433 5.556303665207645 54.3881 54.3881 34.46466735774481 42.356;22.9638 26.3722;18.5144 78.7583;30.0179 0 Exp 3,1(0.5);Linear,1(0.5) 1.7528782734514075 3.5384020805358887 1.5294301509857178 2.008971929550171 0.3390872434851826 1.7692010402679443 13.655543999999999 51.664256 14.742656 30.143944 6.622507999999989 102.153692 DOWN 0.0 1.0 0.0 GO:0051276 6 chromosome organization 85 90 4 4 3 3 2 2 160 88 2297 0.065718 0.98221 0.12226 2.22 257644;25591 zwint;parp1 ZWINT_10214;PARP1_9425 39.4872 39.4872 26.9741 17.69619572733077 33.17586409807355 15.280360646467376 30.35025 30.35025 21.799 12.093293725242926 26.03718520140105 10.442351134259619 58.070499999999996 58.070499999999996 35.2797 32.231058457332736 46.57531541155867 27.830964622795978 52.0003;26.9741 38.9015;21.799 80.8613;35.2797 2 0 2 257644;25591 ZWINT_10214;PARP1_9425 39.4872 39.4872 17.69619572733077 30.35025 30.35025 12.093293725242926 58.070499999999996 58.070499999999996 32.231058457332736 52.0003;26.9741 38.9015;21.799 80.8613;35.2797 0 0 Exp 2,2(1) 1.6584965584174156 3.329461932182312 1.5207922458648682 1.8086696863174438 0.2035600902946428 1.664730966091156 14.961524 64.012876 13.5898 47.110699999999994 13.400531999999998 102.74046799999999 UP 1.0 0.0 0.0 GO:0071704 3 organic substance metabolic process 1263 1393 170 169 122 149 107 107 55 1286 1099 0.99908 0.0016039 0.0032165 7.68 79426;312688;286954;24856;246273;293688;25357;24825;361510;360268;29573;65192;29500;293615;246074;297784;25106;501907;293656;29676;192280;298490;83516;29441;303612;85253;24651;25513;81819;25591;294103;100359982;24552;24539;24516;54404;50693;306251;25685;364070;65164;63868;29540;289456;24464;25675;24443;171155;113965;85255;81869;57298;29328;24957;499914;24384;114860;294515;314322;25661;25256;246186;361969;304929;308441;295143;24890;29496;65030;25315;171142;24330;291075;29740;116663;298541;25428;266682;65210;24894;25146;25423;83842;497840;113936;291394;362866;81718;29184;361239;25698;25028;25377;25284;65183;362732;50681;192272;170570;50559;24158;25287;170465;313917;312382;25303;296925 zfp36;usp18;ugt2b1;ttr;trib3;tm7sf2;thrsp;tf;sult2a2;sult1e1;slc37a4;slc27a2;slc10a2;sirt3;scd;rrs1;rgn;rgd1559459;rgd1307603;psmb3;ppp1r3b;ppcs;ppargc1a;por;polg2;plg;pklr;pik3r1;pax8;parp1;papss2;mpc2;me1;lpl;jun;itih4;itih3;itih1;igfbp1;iars2;htra1;hspd1;hsd17b7;hsd17b11;hp;hmgcr;hdc;hadhb;hadh;hacl1;gstm7;gstm3l;gpx4;glul;gins1;gc;gale;foxo3;fos;fn1;fmo1;fgl1;fga;f5;exosc5;etfdh;esr1;erbb3;ephx2;ephx1;ehhadh;egr1;eci2;eci1;dusp6;dhdds;cyp7a1;cyp3a2;cyp2j4;cyp2a1;cyp17a1;ctsc;crot;cps1;cpb2;cndp2;chpt1;cdo1;cd36;bphl;ass1;ampd1;ambp;amacr;aldh3a2;agmo;acox1;acot2;acot12;acot1;acadm;acadl;acaa2;abhd1;abcg2;abcc2;aass ZFP36_10204;USP18_10138;UGT2B10_33303,UGT2B1_33224;TTR_10102;TRIB3_10079;TM7SF2_10031;THRSP_33314;TF_10003;SULT2A2_33196;SULT1E1_32446;SLC37A4_9871;SLC27A2_9860;SLC10A2_9833;SIRT3_9828;SCD1_9787;RRS1_9755;RGN_9699;RGD1559459_9690;RGD1307603_9684;PSMB3_9589;PPP1R3B_9545;PPCS_9540;PPARGC1A_33189;POR_9531;POLG2_9521;PLG_9501;PKLR_9489;PIK3R1_32562;PAX8_9432;PARP1_9425;PAPSS2_33237;MPC2_33219;ME1_9215;LPL_32544;JUN_8938;ITIH4_32725;ITIH3_32422;ITIH1_33132;IGFBP1_32306;IARS2_8858;HTRA1_8856;HSPD1_8849;HSD17B7_8834;HSD17B11_8832;HP_8823;HMGCR_8810;HDC_8788;HADHB_8777;HADH_8776;HACL1_8775;GSTM7_8761;GSTM3_8760;GPX4_32827;GLUL_32832;GINS1_8707;GC_32893;GALE_8680;FOXO3_8662;FOS_8657;FN1_8655;FMO1_32787;FGL1_8640;FGA_8632;F5_33079;EXOSC5_32543;ETFDH_8575;ESR1_33192;ERBB3_8571;EPHX2_33282;EPHX1_8567;EHHADH_8534;EGR1_8533;ECI2_8521;ECI1_8520;DUSP6_8506;DHDDS_8467;CYP7A1_8430;CYP3A2_32374;CYP2J4_32580;CYP2A1_32717;CYP17A1_32365;CTSC_32456;CROT_8384;CPS1_32421;CPB2_8369;CNDP2_8341;CHPT1_33298;CDO1_8275;CD36_8243;BPHL_8157;ASS1_33159;AMPD1_32743;AMBP_33085;AMACR_8038;ALDH3A2_8024;AGMO_33265;ACOX1_7973;ACOT2_7969;ACOT12_32718;ACOT1_7968;ACADM_7957;ACADL_32776;ACAA2_7955;ABHD1_7949;ABCG2_32656;ABCC2_32541;AASS_7936 36.13564350467291 31.9826 2.52378E-13 24.967323384746305 37.664914565104816 23.849084549441898 25.24295750467292 24.4836 2.52378E-13 16.802691749668725 26.157989074146517 15.69178142909747 61.02097990654207 45.5891 2.52379E-13 54.13598337698577 63.20018576605097 50.78169246770625 68.5 42.75865 0.348134;108.883;47.47345;46.6406;108.064;82.3097;32.2053;45.1539;54.1932;50.1846;39.7166;7.62189;56.585;2.38018;105.46;60.39;77.4407;2.52378E-13;34.7372;23.7888;36.1411;20.3353;42.4094;12.4414;63.7758;70.7857;23.0963;18.7324;56.8931;26.9741;34.4443;46.8463;80.7944;74.2041;16.4324;57.1163;27.1247;98.1741;49.0259;24.7304;33.1323;42.2579;0.977494;22.4334;64.9285;1.63089;24.5745;31.8029;33.3125;17.6275;42.3152;73.0961;45.9204;26.4669;58.9165;42.356;71.148;13.1992;1.28141E-12;59.5777;65.2792;15.4757;28.5803;10.6089;41.9329;18.1231;23.3972;60.9984;38.7293;12.4747;8.62809;0.750017;10.6467;11.9473;62.3934;47.9438;5.72128;12.8505;17.8395;55.3937;49.6922;56.2386;7.4229;31.9826;25.8316;33.544;16.0559;22.9638;48.1296;12.3152;26.8037;60.9045;17.2343;2.03774;43.1079;31.5332;23.1906;8.54905;30.3423;31.2018;11.7137;33.4878;26.5872;17.2895;5.21654;46.2316;27.4644 0.118102;73.1414;34.82915;28.5876;83.8836;51.1696;24.3966;28.132;35.5514;36.5009;22.6911;5.49916;35.2796;0.56209;63.7532;43.109;58.7732;2.52378E-13;26.1766;19.2724;27.0588;16.7643;26.2988;8.48981;40.9553;46.2356;17.4625;11.6701;45.1162;21.799;25.719;35.8494;59.856;49.8682;10.5224;39.6402;21.5108;42.9071;32.6883;19.8021;25.6145;23.9469;0.322682;18.1233;41.6103;0.663137;21.0619;25.5756;25.7336;11.195;31.4035;51.4219;34.2198;21.0456;44.7208;26.3722;43.2839;5.6804;1.28141E-12;31.0499;39.7882;10.2138;22.529;2.59129;31.7336;14.869;18.3088;41.6036;29.2097;7.00435;7.31865;0.186019;8.92359;7.15307;39.0875;36.5688;0.985273;7.33176;14.6501;38.7444;35.6654;38.2681;5.75707;24.4836;20.4374;26.3005;10.6021;18.5144;37.5433;6.6063;20.9825;50.0633;14.1233;1.165;31.8774;24.5474;16.2815;7.19676;24.0157;26.858;8.36151;26.6039;21.3695;14.2242;2.73368;31.1788;21.7498 1.15962;138.144;76.47475;63.7146;143.428;209.842;46.6068;61.5341;103.141;80.9788;60.0334;13.3925;116.8;8.82917;422.699;104.942;89.8047;2.52379E-13;50.9085;30.901;53.6244;25.6711;81.7305;79.2355;132.567;150.579;32.9443;41.5978;81.5688;35.2797;51.1014;69.127;94.0621;155.425;39.929;101.869;36.4819;104.278;89.1623;32.7087;46.6629;102.383;5.49472;29.2247;136.455;7.6286;29.28;42.1484;46.9856;37.6534;64.5991;140.853;70.4292;35.4303;91.837;78.7583;88.9033;32.7581;1.28142E-12;105.243;82.9415;30.4106;38.8511;37.5078;62.1373;23.0103;31.9156;113.972;57.2113;23.684;10.3909;4.70178;13.0581;19.001;133.304;71.3742;22.3625;24.0283;22.6149;96.8569;81.6409;102.888;10.316;45.5891;34.8042;46.311;29.905;30.0179;69.1421;25.5051;36.7081;82.6625;21.9073;3.73641;66.3058;43.8459;33.4539;10.4125;41.1025;37.2719;18.9642;45.3228;35.0407;21.8526;11.386;81.7848;37.0295 61 47 60 312688;286954;24856;24825;360268;65192;293615;246074;297784;25106;29676;298490;81819;25591;100359982;24539;364070;63868;289456;24443;171155;113965;85255;81869;57298;29328;499914;25256;308441;295143;29496;65030;25315;171142;291075;29740;298541;266682;65210;24894;25146;83842;291394;362866;29184;361239;25028;25284;65183;362732;50681;192272;170570;50559;24158;25287;170465;313917;312382;296925 USP18_10138;UGT2B10_33303,UGT2B1_33224;TTR_10102;TF_10003;SULT1E1_32446;SLC27A2_9860;SIRT3_9828;SCD1_9787;RRS1_9755;RGN_9699;PSMB3_9589;PPCS_9540;PAX8_9432;PARP1_9425;MPC2_33219;LPL_32544;IARS2_8858;HSPD1_8849;HSD17B11_8832;HDC_8788;HADHB_8777;HADH_8776;HACL1_8775;GSTM7_8761;GSTM3_8760;GPX4_32827;GINS1_8707;FMO1_32787;EXOSC5_32543;ETFDH_8575;ERBB3_8571;EPHX2_33282;EPHX1_8567;EHHADH_8534;ECI2_8521;ECI1_8520;DHDDS_8467;CYP3A2_32374;CYP2J4_32580;CYP2A1_32717;CYP17A1_32365;CROT_8384;CNDP2_8341;CHPT1_33298;CD36_8243;BPHL_8157;AMPD1_32743;AMACR_8038;ALDH3A2_8024;AGMO_33265;ACOX1_7973;ACOT2_7969;ACOT12_32718;ACOT1_7968;ACADM_7957;ACADL_32776;ACAA2_7955;ABHD1_7949;ABCG2_32656;AASS_7936 35.670509 31.66805 23.657586666054883 25.886378999999994 25.061500000000002 16.248827475710232 58.634605500000006 42.997150000000005 59.40600599822702 108.883;47.47345;46.6406;45.1539;50.1846;7.62189;2.38018;105.46;60.39;77.4407;23.7888;20.3353;56.8931;26.9741;46.8463;74.2041;24.7304;42.2579;22.4334;24.5745;31.8029;33.3125;17.6275;42.3152;73.0961;45.9204;58.9165;65.2792;41.9329;18.1231;60.9984;38.7293;12.4747;8.62809;10.6467;11.9473;47.9438;12.8505;17.8395;55.3937;49.6922;7.4229;33.544;16.0559;48.1296;12.3152;60.9045;2.03774;43.1079;31.5332;23.1906;8.54905;30.3423;31.2018;11.7137;33.4878;26.5872;17.2895;5.21654;27.4644 73.1414;34.82915;28.5876;28.132;36.5009;5.49916;0.56209;63.7532;43.109;58.7732;19.2724;16.7643;45.1162;21.799;35.8494;49.8682;19.8021;23.9469;18.1233;21.0619;25.5756;25.7336;11.195;31.4035;51.4219;34.2198;44.7208;39.7882;31.7336;14.869;41.6036;29.2097;7.00435;7.31865;8.92359;7.15307;36.5688;7.33176;14.6501;38.7444;35.6654;5.75707;26.3005;10.6021;37.5433;6.6063;50.0633;1.165;31.8774;24.5474;16.2815;7.19676;24.0157;26.858;8.36151;26.6039;21.3695;14.2242;2.73368;21.7498 138.144;76.47475;63.7146;61.5341;80.9788;13.3925;8.82917;422.699;104.942;89.8047;30.901;25.6711;81.5688;35.2797;69.127;155.425;32.7087;102.383;29.2247;29.28;42.1484;46.9856;37.6534;64.5991;140.853;70.4292;91.837;82.9415;62.1373;23.0103;113.972;57.2113;23.684;10.3909;13.0581;19.001;71.3742;24.0283;22.6149;96.8569;81.6409;10.316;46.311;29.905;69.1421;25.5051;82.6625;3.73641;66.3058;43.8459;33.4539;10.4125;41.1025;37.2719;18.9642;45.3228;35.0407;21.8526;11.386;37.0295 47 79426;246273;293688;25357;361510;29573;29500;501907;293656;192280;83516;29441;303612;85253;24651;25513;294103;24552;24516;54404;50693;306251;25685;65164;29540;24464;25675;24957;24384;114860;294515;314322;25661;246186;361969;304929;24890;24330;116663;25428;25423;497840;113936;81718;25698;25377;25303 ZFP36_10204;TRIB3_10079;TM7SF2_10031;THRSP_33314;SULT2A2_33196;SLC37A4_9871;SLC10A2_9833;RGD1559459_9690;RGD1307603_9684;PPP1R3B_9545;PPARGC1A_33189;POR_9531;POLG2_9521;PLG_9501;PKLR_9489;PIK3R1_32562;PAPSS2_33237;ME1_9215;JUN_8938;ITIH4_32725;ITIH3_32422;ITIH1_33132;IGFBP1_32306;HTRA1_8856;HSD17B7_8834;HP_8823;HMGCR_8810;GLUL_32832;GC_32893;GALE_8680;FOXO3_8662;FOS_8657;FN1_8655;FGL1_8640;FGA_8632;F5_33079;ESR1_33192;EGR1_8533;DUSP6_8506;CYP7A1_8430;CTSC_32456;CPS1_32421;CPB2_8369;CDO1_8275;ASS1_33159;AMBP_33085;ABCC2_32541 36.729432234042584 32.2053 26.794780321090048 24.421568361702157 24.3966 17.627201681036265 64.06741531914898 46.6629 47.01097821068752 0.348134;108.064;82.3097;32.2053;54.1932;39.7166;56.585;2.52378E-13;34.7372;36.1411;42.4094;12.4414;63.7758;70.7857;23.0963;18.7324;34.4443;80.7944;16.4324;57.1163;27.1247;98.1741;49.0259;33.1323;0.977494;64.9285;1.63089;26.4669;42.356;71.148;13.1992;1.28141E-12;59.5777;15.4757;28.5803;10.6089;23.3972;0.750017;62.3934;5.72128;56.2386;31.9826;25.8316;22.9638;26.8037;17.2343;46.2316 0.118102;83.8836;51.1696;24.3966;35.5514;22.6911;35.2796;2.52378E-13;26.1766;27.0588;26.2988;8.48981;40.9553;46.2356;17.4625;11.6701;25.719;59.856;10.5224;39.6402;21.5108;42.9071;32.6883;25.6145;0.322682;41.6103;0.663137;21.0456;26.3722;43.2839;5.6804;1.28141E-12;31.0499;10.2138;22.529;2.59129;18.3088;0.186019;39.0875;0.985273;38.2681;24.4836;20.4374;18.5144;20.9825;14.1233;31.1788 1.15962;143.428;209.842;46.6068;103.141;60.0334;116.8;2.52379E-13;50.9085;53.6244;81.7305;79.2355;132.567;150.579;32.9443;41.5978;51.1014;94.0621;39.929;101.869;36.4819;104.278;89.1623;46.6629;5.49472;136.455;7.6286;35.4303;78.7583;88.9033;32.7581;1.28142E-12;105.243;30.4106;38.8511;37.5078;31.9156;4.70178;133.304;22.3625;102.888;45.5891;34.8042;30.0179;36.7081;21.9073;81.7848 0 Exp 2,45(0.42);Exp 3,3(0.03);Exp 4,6(0.06);Hill,11(0.11);Linear,24(0.23);Poly 2,16(0.15);Power,3(0.03) 2.2522827717207026 633.9875301122665 1.5074360370635986 344.14306640625 33.054928537341134 1.841676950454712 31.404826284904804 40.86646072444104 22.059177559869006 28.42673744947679 50.76327472836535 71.27868508471877 CONFLICT 0.5607476635514018 0.4392523364485981 0.0 GO:0016477 4 cell migration 189 200 10 10 5 9 5 5 157 195 2190 0.0087413 0.99718 0.015314 2.5 29573;85253;25493;25661;140942 slc37a4;plg;nfkbia;fn1;ddit4 SLC37A4_9871;PLG_9501;NFKBIA_9307;FN1_8655;DDIT4_8450 51.628450199999996 59.5777 0.520151 33.44372682784996 56.49733445193413 20.623850636592437 30.676420399999994 31.0499 0.160202 20.896092999428884 33.03734482740852 13.860799034581749 112.846478 105.243 2.88499 92.1373168860447 110.19798650673725 59.89752402387743 39.7166;70.7857;0.520151;59.5777;87.5421 22.6911;46.2356;0.160202;31.0499;53.2453 60.0334;150.579;2.88499;105.243;245.492 0 5 0 5 29573;85253;25493;25661;140942 SLC37A4_9871;PLG_9501;NFKBIA_9307;FN1_8655;DDIT4_8450 51.628450199999996 59.5777 33.44372682784996 30.676420399999994 31.0499 20.896092999428884 112.846478 105.243 92.1373168860447 39.7166;70.7857;0.520151;59.5777;87.5421 22.6911;46.2356;0.160202;31.0499;53.2453 60.0334;150.579;2.88499;105.243;245.492 0 Exp 4,1(0.2);Linear,2(0.4);Poly 2,1(0.2);Power,1(0.2) 1.7387333115647032 8.720110297203064 1.5254690647125244 1.893584966659546 0.14958463731683594 1.7792335748672485 22.313731129661694 80.94316927033832 12.360187310934862 48.99265348906514 32.084558901918996 193.60839709808099 DOWN 0.0 1.0 0.0 GO:0007565 4 female pregnancy 40 42 6 6 6 6 6 6 156 36 2349 0.98495 0.047034 0.047034 14.29 360268;24471;24384;314322;65210;25303 sult1e1;hspb1;gc;fos;cyp2j4;abcc2 SULT1E1_32446;HSPB1_8847;GC_32893;FOS_8657;CYP2J4_32580;ABCC2_32541 40.95213333333355 44.293800000000005 1.28141E-12 30.478438561951393 45.105246909024466 29.609761091508258 28.171416666666882 28.7755 1.28141E-12 20.45515061449444 30.88124449663006 19.644088550232944 61.71246666666688 79.86855 1.28142E-12 40.927562529115214 66.8048873951631 37.638414202803936 1.5 30.09775 3.5 48.2081 50.1846;89.1011;42.356;1.28141E-12;17.8395;46.2316 36.5009;60.3265;26.3722;1.28141E-12;14.6501;31.1788 80.9788;106.138;78.7583;1.28142E-12;22.6149;81.7848 2 4 2 360268;65210 SULT1E1_32446;CYP2J4_32580 34.01205 34.01205 22.871439548157007 25.5755 25.5755 15.450848854351015 51.796850000000006 51.796850000000006 41.26950946649354 50.1846;17.8395 36.5009;14.6501 80.9788;22.6149 4 24471;24384;314322;25303 HSPB1_8847;GC_32893;FOS_8657;ABCC2_32541 44.42217500000032 44.293800000000005 36.4100676042922 29.46937500000032 28.7755 24.719229039807754 66.67027500000032 80.27155 46.105661617735315 89.1011;42.356;1.28141E-12;46.2316 60.3265;26.3722;1.28141E-12;31.1788 106.138;78.7583;1.28142E-12;81.7848 0 Exp 2,2(0.34);Exp 3,1(0.17);Hill,1(0.17);Linear,1(0.17);Poly 2,1(0.17) 1.9821661515157587 12.53052568435669 1.5294301509857178 3.8079800605773926 0.8524104558435915 1.7995648384094238 16.564303273041457 65.33996339362564 11.803887338352421 44.53894599498135 28.96359609335316 94.46133723998061 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0065003 6 protein-containing complex assembly 203 233 16 15 11 12 8 8 154 225 2160 0.030458 0.98638 0.065417 3.43 29482;297784;298699;29328;25661;361969;25373;312382 slc1a2;rrs1;ppan;gpx4;fn1;fga;ahsg;abcg2 SLC1A2_33059;RRS1_9755;PPAN_9534;GPX4_32827;FN1_8655;FGA_8632;AHSG_8003;ABCG2_32656 35.3874175 37.25035 5.21654 23.269732983970986 36.21771512976746 23.428887157067287 24.3022625 26.789450000000002 2.73368 15.510106606300063 24.073932248274268 15.03643972652925 58.640775 54.64015 11.386 40.81896801802354 60.421478411939376 41.27912579756976 13.3235;60.39;57.6889;45.9204;59.5777;28.5803;12.402;5.21654 9.10952;43.109;41.3659;34.2198;31.0499;22.529;10.3013;2.73368 24.6773;104.942;98.1741;70.4292;105.243;38.8511;15.4235;11.386 4 4 4 297784;298699;29328;312382 RRS1_9755;PPAN_9534;GPX4_32827;ABCG2_32656 42.303960000000004 51.804649999999995 25.510498376258088 30.357095 37.79285 18.812924766733293 71.23282499999999 84.30165 42.60058314752472 60.39;57.6889;45.9204;5.21654 43.109;41.3659;34.2198;2.73368 104.942;98.1741;70.4292;11.386 4 29482;25661;361969;25373 SLC1A2_33059;FN1_8655;FGA_8632;AHSG_8003 28.470875 20.951900000000002 22.024972558193273 18.24743 16.41515 10.470234968882025 46.048725 31.764200000000002 40.62187510544657 13.3235;59.5777;28.5803;12.402 9.10952;31.0499;22.529;10.3013 24.6773;105.243;38.8511;15.4235 0 Exp 2,4(0.5);Exp 4,1(0.13);Linear,1(0.13);Poly 2,1(0.13);Power,1(0.13) 1.8612549479763745 15.483530521392822 1.5074360370635986 3.431420087814331 0.654249694654347 1.696900725364685 19.262315230421166 51.51251976957883 13.554306972923778 35.05021802707623 30.354673295150366 86.92687670484962 CONFLICT 0.5 0.5 0.0 GO:0019827 3 stem cell population maintenance 26 27 2 2 2 2 2 2 160 25 2360 0.75576 0.5205 0.6885 7.41 290556;294515 gnl3;foxo3 GNL3_8735;FOXO3_8662 50.41745 50.41745 13.1992 52.634553917792445 43.09002807196198 51.604399443284045 30.045199999999998 30.045199999999998 5.6804 34.457030604507985 25.248328309572297 33.7826435030053 135.86055 135.86055 32.7581 145.8088831038939 115.56203642226747 142.95513661661204 0.5 50.41745 87.6357;13.1992 54.41;5.6804 238.963;32.7581 1 1 1 290556 GNL3_8735 87.6357 87.6357 54.41 54.41 238.963 238.963 87.6357 54.41 238.963 1 294515 FOXO3_8662 13.1992 13.1992 5.6804 5.6804 32.7581 32.7581 13.1992 5.6804 32.7581 0 Exp 2,1(0.5);Exp 4,1(0.5) 1.7738674755752115 3.5708693265914917 1.582527995109558 1.9883413314819336 0.2869533620448441 1.7854346632957458 -22.53031999999999 123.36522 -17.709807999999992 77.80020799999998 -66.22025200000002 337.941352 CONFLICT 0.5 0.5 0.0 GO:0043069 7 negative regulation of programmed cell death 287 304 30 30 25 26 21 21 141 283 2102 0.71275 0.3757 0.70668 6.91 25106;83516;29441;25513;81819;24314;24567;24516;192235;63868;24471;25675;29328;25661;361969;24360;29496;114851;246142;50559;170465 rgn;ppargc1a;por;pik3r1;pax8;nqo1;mt1;jun;hyou1;hspd1;hspb1;hmgcr;gpx4;fn1;fga;fabp1;erbb3;cdkn1a;bmf;acot1;acaa2 RGN_9699;PPARGC1A_33189;POR_9531;PIK3R1_32562;PAX8_9432;NQO1_33055;MT1A_9255;JUN_8938;HYOU1_8857;HSPD1_8849;HSPB1_8847;HMGCR_8810;GPX4_32827;FN1_8655;FGA_8632;FABP1_33091;ERBB3_8571;CDKN1A_8271;BMF_8152;ACOT1_7968;ACAA2_7955 42.170736190476184 40.1982 1.63089 27.97556622816553 44.61062136627506 27.19754744961254 29.737087000000002 26.4736 0.663137 20.466481155466518 31.58039198877947 20.134981790970258 70.93313333333333 70.4292 7.6286 43.71707239902205 70.44399044630462 35.349886246587765 14.5 58.2354 77.4407;42.4094;12.4414;18.7324;56.8931;87.2765;12.9315;16.4324;40.1982;42.2579;89.1011;1.63089;45.9204;59.5777;28.5803;33.8478;60.9984;6.24967;94.8767;31.2018;26.5872 58.7732;26.2988;8.48981;11.6701;45.1162;60.6992;8.91033;10.5224;29.3844;23.9469;60.3265;0.663137;34.2198;31.0499;22.529;26.4736;41.6036;2.44025;73.1342;26.858;21.3695 89.8047;81.7305;79.2355;41.5978;81.5688;197.117;23.4636;39.929;62.3571;102.383;106.138;7.6286;70.4292;105.243;38.8511;46.9257;113.972;19.0606;109.848;37.2719;35.0407 10 11 10 25106;81819;24314;63868;29328;24360;29496;246142;50559;170465 RGN_9699;PAX8_9432;NQO1_33055;HSPD1_8849;GPX4_32827;FABP1_33091;ERBB3_8571;BMF_8152;ACOT1_7968;ACAA2_7955 55.73004999999999 51.40675 24.119150787208753 41.21942000000001 37.911699999999996 17.908800553594975 88.4361 85.68674999999999 47.93727896215591 77.4407;56.8931;87.2765;42.2579;45.9204;33.8478;60.9984;94.8767;31.2018;26.5872 58.7732;45.1162;60.6992;23.9469;34.2198;26.4736;41.6036;73.1342;26.858;21.3695 89.8047;81.5688;197.117;102.383;70.4292;46.9257;113.972;109.848;37.2719;35.0407 11 83516;29441;25513;24567;24516;192235;24471;25675;25661;361969;114851 PPARGC1A_33189;POR_9531;PIK3R1_32562;MT1A_9255;JUN_8938;HYOU1_8857;HSPB1_8847;HMGCR_8810;FN1_8655;FGA_8632;CDKN1A_8271 29.84408727272727 18.7324 26.281336124058118 19.298602454545456 11.6701 17.245258813464652 55.02134545454546 41.5978 34.195366066657726 42.4094;12.4414;18.7324;12.9315;16.4324;40.1982;89.1011;1.63089;59.5777;28.5803;6.24967 26.2988;8.48981;11.6701;8.91033;10.5224;29.3844;60.3265;0.663137;31.0499;22.529;2.44025 81.7305;79.2355;41.5978;23.4636;39.929;62.3571;106.138;7.6286;105.243;38.8511;19.0606 0 Exp 2,8(0.39);Exp 3,1(0.05);Exp 4,2(0.1);Linear,2(0.1);Poly 2,7(0.34);Power,1(0.05) 2.321918515870663 380.7620874643326 1.522104263305664 344.14306640625 74.69927143515903 1.7521979808807373 30.205388871159776 54.136083509792606 20.983428416930824 38.49074558306917 52.23503261316422 89.63123405350241 CONFLICT 0.47619047619047616 0.5238095238095238 0.0 GO:0048662 7 negative regulation of smooth muscle cell proliferation 29 29 5 5 5 4 4 4 158 25 2360 0.96652 0.1084 0.1084 13.79 83516;25513;24890;114851 ppargc1a;pik3r1;esr1;cdkn1a PPARGC1A_33189;PIK3R1_32562;ESR1_33192;CDKN1A_8271 22.6971675 21.064799999999998 6.24967 15.00335196966192 20.08880829466119 17.5450977411077 14.6794875 14.989450000000001 2.44025 10.116581766286394 12.138061237166324 11.754818640034667 43.576125000000005 36.7567 19.0606 27.05949562690517 41.712668398357295 30.53190375515265 0.5 12.491035 1.5 21.064799999999998 42.4094;18.7324;23.3972;6.24967 26.2988;11.6701;18.3088;2.44025 81.7305;41.5978;31.9156;19.0606 0 4 0 4 83516;25513;24890;114851 PPARGC1A_33189;PIK3R1_32562;ESR1_33192;CDKN1A_8271 22.6971675 21.064799999999998 15.00335196966192 14.6794875 14.989450000000001 10.116581766286394 43.576125000000005 36.7567 27.05949562690517 42.4094;18.7324;23.3972;6.24967 26.2988;11.6701;18.3088;2.44025 81.7305;41.5978;31.9156;19.0606 0 Exp 2,2(0.5);Exp 4,1(0.25);Poly 2,1(0.25) 1.8174707389096723 7.390293598175049 1.522104263305664 2.436986207962036 0.40484662261166027 1.7156015634536743 7.993882569731314 37.400452430268686 4.765237369039335 24.593737630960668 17.057819285632934 70.09443071436708 DOWN 0.0 1.0 0.0 GO:0006807 3 nitrogen compound metabolic process 1028 1128 105 104 74 94 67 67 95 1061 1324 0.24435 0.80416 0.46261 5.94 79426;312688;24856;246273;24825;360268;293615;297784;293656;29676;192280;298490;29441;303612;85253;24651;25513;81819;25591;294103;100359982;24516;54404;50693;306251;364070;65164;63868;24464;25675;24443;81869;57298;29328;24957;499914;294515;314322;25661;361969;304929;308441;24890;29496;171142;24330;116663;25423;83842;497840;113936;291394;362866;81718;29184;25698;25028;25377;192272;170570;50559;24158;25287;170465;312382;25303;296925 zfp36;usp18;ttr;trib3;tf;sult1e1;sirt3;rrs1;rgd1307603;psmb3;ppp1r3b;ppcs;por;polg2;plg;pklr;pik3r1;pax8;parp1;papss2;mpc2;jun;itih4;itih3;itih1;iars2;htra1;hspd1;hp;hmgcr;hdc;gstm7;gstm3l;gpx4;glul;gins1;foxo3;fos;fn1;fga;f5;exosc5;esr1;erbb3;ehhadh;egr1;dusp6;ctsc;crot;cps1;cpb2;cndp2;chpt1;cdo1;cd36;ass1;ampd1;ambp;acot2;acot12;acot1;acadm;acadl;acaa2;abcg2;abcc2;aass ZFP36_10204;USP18_10138;TTR_10102;TRIB3_10079;TF_10003;SULT1E1_32446;SIRT3_9828;RRS1_9755;RGD1307603_9684;PSMB3_9589;PPP1R3B_9545;PPCS_9540;POR_9531;POLG2_9521;PLG_9501;PKLR_9489;PIK3R1_32562;PAX8_9432;PARP1_9425;PAPSS2_33237;MPC2_33219;JUN_8938;ITIH4_32725;ITIH3_32422;ITIH1_33132;IARS2_8858;HTRA1_8856;HSPD1_8849;HP_8823;HMGCR_8810;HDC_8788;GSTM7_8761;GSTM3_8760;GPX4_32827;GLUL_32832;GINS1_8707;FOXO3_8662;FOS_8657;FN1_8655;FGA_8632;F5_33079;EXOSC5_32543;ESR1_33192;ERBB3_8571;EHHADH_8534;EGR1_8533;DUSP6_8506;CTSC_32456;CROT_8384;CPS1_32421;CPB2_8369;CNDP2_8341;CHPT1_33298;CDO1_8275;CD36_8243;ASS1_33159;AMPD1_32743;AMBP_33085;ACOT2_7969;ACOT12_32718;ACOT1_7968;ACADM_7957;ACADL_32776;ACAA2_7955;ABCG2_32656;ABCC2_32541;AASS_7936 35.90784031343286 31.2018 1.28141E-12 24.45839445949237 39.2929325558148 23.59997691927916 25.431740567164198 24.0157 1.28141E-12 16.584892479537366 27.53208995981498 15.41579272546598 57.880718955223905 45.3228 1.28142E-12 40.022774985793745 63.346942305293304 39.56045044027742 55.5 59.983850000000004 0.348134;108.883;46.6406;108.064;45.1539;50.1846;2.38018;60.39;34.7372;23.7888;36.1411;20.3353;12.4414;63.7758;70.7857;23.0963;18.7324;56.8931;26.9741;34.4443;46.8463;16.4324;57.1163;27.1247;98.1741;24.7304;33.1323;42.2579;64.9285;1.63089;24.5745;42.3152;73.0961;45.9204;26.4669;58.9165;13.1992;1.28141E-12;59.5777;28.5803;10.6089;41.9329;23.3972;60.9984;8.62809;0.750017;62.3934;56.2386;7.4229;31.9826;25.8316;33.544;16.0559;22.9638;48.1296;26.8037;60.9045;17.2343;8.54905;30.3423;31.2018;11.7137;33.4878;26.5872;5.21654;46.2316;27.4644 0.118102;73.1414;28.5876;83.8836;28.132;36.5009;0.56209;43.109;26.1766;19.2724;27.0588;16.7643;8.48981;40.9553;46.2356;17.4625;11.6701;45.1162;21.799;25.719;35.8494;10.5224;39.6402;21.5108;42.9071;19.8021;25.6145;23.9469;41.6103;0.663137;21.0619;31.4035;51.4219;34.2198;21.0456;44.7208;5.6804;1.28141E-12;31.0499;22.529;2.59129;31.7336;18.3088;41.6036;7.31865;0.186019;39.0875;38.2681;5.75707;24.4836;20.4374;26.3005;10.6021;18.5144;37.5433;20.9825;50.0633;14.1233;7.19676;24.0157;26.858;8.36151;26.6039;21.3695;2.73368;31.1788;21.7498 1.15962;138.144;63.7146;143.428;61.5341;80.9788;8.82917;104.942;50.9085;30.901;53.6244;25.6711;79.2355;132.567;150.579;32.9443;41.5978;81.5688;35.2797;51.1014;69.127;39.929;101.869;36.4819;104.278;32.7087;46.6629;102.383;136.455;7.6286;29.28;64.5991;140.853;70.4292;35.4303;91.837;32.7581;1.28142E-12;105.243;38.8511;37.5078;62.1373;31.9156;113.972;10.3909;4.70178;133.304;102.888;10.316;45.5891;34.8042;46.311;29.905;30.0179;69.1421;36.7081;82.6625;21.9073;10.4125;41.1025;37.2719;18.9642;45.3228;35.0407;11.386;81.7848;37.0295 34 33 34 312688;24856;24825;360268;293615;297784;29676;298490;81819;25591;100359982;364070;63868;24443;81869;57298;29328;499914;308441;29496;171142;83842;291394;362866;29184;25028;192272;170570;50559;24158;25287;170465;312382;296925 USP18_10138;TTR_10102;TF_10003;SULT1E1_32446;SIRT3_9828;RRS1_9755;PSMB3_9589;PPCS_9540;PAX8_9432;PARP1_9425;MPC2_33219;IARS2_8858;HSPD1_8849;HDC_8788;GSTM7_8761;GSTM3_8760;GPX4_32827;GINS1_8707;EXOSC5_32543;ERBB3_8571;EHHADH_8534;CROT_8384;CNDP2_8341;CHPT1_33298;CD36_8243;AMPD1_32743;ACOT2_7969;ACOT12_32718;ACOT1_7968;ACADM_7957;ACADL_32776;ACAA2_7955;ABCG2_32656;AASS_7936 36.83705764705883 33.5159 22.488288139648752 27.212416470588245 26.452199999999998 15.80175359721898 55.710210882352946 45.816900000000004 36.185120283341654 108.883;46.6406;45.1539;50.1846;2.38018;60.39;23.7888;20.3353;56.8931;26.9741;46.8463;24.7304;42.2579;24.5745;42.3152;73.0961;45.9204;58.9165;41.9329;60.9984;8.62809;7.4229;33.544;16.0559;48.1296;60.9045;8.54905;30.3423;31.2018;11.7137;33.4878;26.5872;5.21654;27.4644 73.1414;28.5876;28.132;36.5009;0.56209;43.109;19.2724;16.7643;45.1162;21.799;35.8494;19.8021;23.9469;21.0619;31.4035;51.4219;34.2198;44.7208;31.7336;41.6036;7.31865;5.75707;26.3005;10.6021;37.5433;50.0633;7.19676;24.0157;26.858;8.36151;26.6039;21.3695;2.73368;21.7498 138.144;63.7146;61.5341;80.9788;8.82917;104.942;30.901;25.6711;81.5688;35.2797;69.127;32.7087;102.383;29.28;64.5991;140.853;70.4292;91.837;62.1373;113.972;10.3909;10.316;46.311;29.905;69.1421;82.6625;10.4125;41.1025;37.2719;18.9642;45.3228;35.0407;11.386;37.0295 33 79426;246273;293656;192280;29441;303612;85253;24651;25513;294103;24516;54404;50693;306251;65164;24464;25675;24957;294515;314322;25661;361969;304929;24890;24330;116663;25423;497840;113936;81718;25698;25377;25303 ZFP36_10204;TRIB3_10079;RGD1307603_9684;PPP1R3B_9545;POR_9531;POLG2_9521;PLG_9501;PKLR_9489;PIK3R1_32562;PAPSS2_33237;JUN_8938;ITIH4_32725;ITIH3_32422;ITIH1_33132;HTRA1_8856;HP_8823;HMGCR_8810;GLUL_32832;FOXO3_8662;FOS_8657;FN1_8655;FGA_8632;F5_33079;ESR1_33192;EGR1_8533;DUSP6_8506;CTSC_32456;CPS1_32421;CPB2_8369;CDO1_8275;ASS1_33159;AMBP_33085;ABCC2_32541 34.950464878787926 27.1247 26.653796431988663 23.597104787878827 21.5108 17.40603430446906 60.11700000000005 41.5978 44.083053874814176 0.348134;108.064;34.7372;36.1411;12.4414;63.7758;70.7857;23.0963;18.7324;34.4443;16.4324;57.1163;27.1247;98.1741;33.1323;64.9285;1.63089;26.4669;13.1992;1.28141E-12;59.5777;28.5803;10.6089;23.3972;0.750017;62.3934;56.2386;31.9826;25.8316;22.9638;26.8037;17.2343;46.2316 0.118102;83.8836;26.1766;27.0588;8.48981;40.9553;46.2356;17.4625;11.6701;25.719;10.5224;39.6402;21.5108;42.9071;25.6145;41.6103;0.663137;21.0456;5.6804;1.28141E-12;31.0499;22.529;2.59129;18.3088;0.186019;39.0875;38.2681;24.4836;20.4374;18.5144;20.9825;14.1233;31.1788 1.15962;143.428;50.9085;53.6244;79.2355;132.567;150.579;32.9443;41.5978;51.1014;39.929;101.869;36.4819;104.278;46.6629;136.455;7.6286;35.4303;32.7581;1.28142E-12;105.243;38.8511;37.5078;31.9156;4.70178;133.304;102.888;45.5891;34.8042;30.0179;36.7081;21.9073;81.7848 0 Exp 2,34(0.51);Exp 3,2(0.03);Exp 4,3(0.05);Hill,5(0.08);Linear,12(0.18);Poly 2,9(0.14);Power,2(0.03) 2.250163925274593 528.7003041505814 1.5074360370635986 344.14306640625 41.931894772283044 1.8086696863174438 30.05122612994437 41.76445449692135 21.460453053253275 29.403028081075128 48.297180999264675 67.46425691118314 CONFLICT 0.5074626865671642 0.4925373134328358 0.0 GO:0007178 7 transmembrane receptor protein serine/threonine kinase signaling pathway 41 43 6 6 5 6 5 5 157 38 2347 0.9481 0.1342 0.19203 11.63 25591;24516;29455;314322;24330 parp1;jun;gdf15;fos;egr1 PARP1_9425;JUN_8938;GDF15_33113;FOS_8657;EGR1_8533 29.861103400000257 16.4324 1.28141E-12 43.5777267814154 37.47983602798168 46.44458555232851 23.571223800000254 10.5224 1.28141E-12 35.68031509239327 29.926799027207487 38.02570136646852 41.11249600000026 35.2797 1.28142E-12 50.49338440703943 49.206326332166014 53.281693769506134 1.5 8.5912085 3.5 66.06155 26.9741;16.4324;105.149;1.28141E-12;0.750017 21.799;10.5224;85.3487;1.28141E-12;0.186019 35.2797;39.929;125.652;1.28142E-12;4.70178 1 4 1 25591 PARP1_9425 26.9741 26.9741 21.799 21.799 35.2797 35.2797 26.9741 21.799 35.2797 4 24516;29455;314322;24330 JUN_8938;GDF15_33113;FOS_8657;EGR1_8533 30.58285425000032 8.5912085 50.284704765144504 24.01427975000032 5.3542095 41.1841942532701 42.57069500000032 22.31539 58.183046181959774 16.4324;105.149;1.28141E-12;0.750017 10.5224;85.3487;1.28141E-12;0.186019 39.929;125.652;1.28142E-12;4.70178 0 Exp 2,1(0.2);Hill,2(0.4);Poly 2,2(0.4) 2.138080727246865 11.46274709701538 1.5606178045272827 4.21828556060791 1.0878497687335398 1.8966681957244873 -8.336458280157657 68.05866508015818 -7.70395132203933 54.84639892203984 -3.1469068596816427 85.37189885968215 DOWN 0.2 0.8 0.0 GO:0048513 4 animal organ development 418 452 49 49 34 40 27 27 135 425 1960 0.40262 0.67802 0.8316 5.97 24522;308843;29573;246074;25106;85253;81819;294103;25493;24516;65164;24464;25661;361969;24890;29496;25315;116636;24330;140942;25146;497840;113936;114851;25698;25373;24158 zfp354a;tsku;slc37a4;scd;rgn;plg;pax8;papss2;nfkbia;jun;htra1;hp;fn1;fga;esr1;erbb3;ephx1;eif4ebp1;egr1;ddit4;cyp17a1;cps1;cpb2;cdkn1a;ass1;ahsg;acadm ZFP354A_10203;TSKU_10094;SLC37A4_9871;SCD1_9787;RGN_9699;PLG_9501;PAX8_9432;PAPSS2_33237;NFKBIA_9307;JUN_8938;HTRA1_8856;HP_8823;FN1_8655;FGA_8632;ESR1_33192;ERBB3_8571;EPHX1_8567;EIF4EBP1_8550;EGR1_8533;DDIT4_8450;CYP17A1_32365;CPS1_32421;CPB2_8369;CDKN1A_8271;ASS1_33159;AHSG_8003;ACADM_7957 37.92106388888889 31.9826 0.520151 30.12275755197218 38.86516481256956 28.835215073609415 25.18609811111111 22.6911 0.160202 18.986225818240218 25.49322840545016 18.378170713831228 74.52576148148148 45.5891 2.88499 89.0055350595261 71.94600216799626 76.35067362612278 21.5 67.8571 0.834827;1.38416;39.7166;105.46;77.4407;70.7857;56.8931;34.4443;0.520151;16.4324;33.1323;64.9285;59.5777;28.5803;23.3972;60.9984;12.4747;83.9001;0.750017;87.5421;49.6922;31.9826;25.8316;6.24967;26.8037;12.402;11.7137 0.27095;0.540568;22.6911;63.7532;58.7732;46.2356;45.1162;25.719;0.160202;10.5224;25.6145;41.6103;31.0499;22.529;18.3088;41.6036;7.00435;42.4185;0.186019;53.2453;35.6654;24.4836;20.4374;2.44025;20.9825;10.3013;8.36151 2.99857;4.10872;60.0334;422.699;89.8047;150.579;81.5688;51.1014;2.88499;39.929;46.6629;136.455;105.243;38.8511;31.9156;113.972;23.684;107.32;4.70178;245.492;81.6409;45.5891;34.8042;19.0606;36.7081;15.4235;18.9642 8 19 8 246074;25106;81819;29496;25315;116636;25146;24158 SCD1_9787;RGN_9699;PAX8_9432;ERBB3_8571;EPHX1_8567;EIF4EBP1_8550;CYP17A1_32365;ACADM_7957 57.3216125 58.94575 32.93225860652385 37.836995 42.01105 20.778803508288373 117.45670000000001 85.7228 128.23928267771262 105.46;77.4407;56.8931;60.9984;12.4747;83.9001;49.6922;11.7137 63.7532;58.7732;45.1162;41.6036;7.00435;42.4185;35.6654;8.36151 422.699;89.8047;81.5688;113.972;23.684;107.32;81.6409;18.9642 19 24522;308843;29573;85253;294103;25493;24516;65164;24464;25661;361969;24890;24330;140942;497840;113936;114851;25698;25373 ZFP354A_10203;TSKU_10094;SLC37A4_9871;PLG_9501;PAPSS2_33237;NFKBIA_9307;JUN_8938;HTRA1_8856;HP_8823;FN1_8655;FGA_8632;ESR1_33192;EGR1_8533;DDIT4_8450;CPS1_32421;CPB2_8369;CDKN1A_8271;ASS1_33159;AHSG_8003 29.75241184210526 26.8037 25.518290877062693 19.859404684210524 20.9825 15.8650982830117 56.449576842105266 38.8511 62.317144632347095 0.834827;1.38416;39.7166;70.7857;34.4443;0.520151;16.4324;33.1323;64.9285;59.5777;28.5803;23.3972;0.750017;87.5421;31.9826;25.8316;6.24967;26.8037;12.402 0.27095;0.540568;22.6911;46.2356;25.719;0.160202;10.5224;25.6145;41.6103;31.0499;22.529;18.3088;0.186019;53.2453;24.4836;20.4374;2.44025;20.9825;10.3013 2.99857;4.10872;60.0334;150.579;51.1014;2.88499;39.929;46.6629;136.455;105.243;38.8511;31.9156;4.70178;245.492;45.5891;34.8042;19.0606;36.7081;15.4235 0 Exp 2,9(0.34);Exp 3,1(0.04);Exp 4,2(0.08);Hill,4(0.15);Linear,6(0.23);Poly 2,4(0.15);Power,1(0.04) 1.9950067488632008 56.7169144153595 1.522104263305664 4.591650485992432 0.8031732085215888 1.8057876825332642 26.558694197063772 49.28343358071399 18.024452420901188 32.347743801321045 40.952679992505225 108.09884297045774 DOWN 0.2962962962962963 0.7037037037037037 0.0 GO:0007566 3 embryo implantation 18 18 1 1 1 1 1 1 161 17 2368 0.68088 0.69487 1.0 5.56 252922 pzp PZP_9633 34.1871 34.1871 34.1871 34.1871 26.3085 26.3085 26.3085 26.3085 48.5666 48.5666 48.5666 48.5666 0.0 34.1871 34.1871 26.3085 48.5666 0 1 0 1 252922 PZP_9633 34.1871 34.1871 26.3085 26.3085 48.5666 48.5666 34.1871 26.3085 48.5666 0 Linear,1(1) 1.679053544998169 1.679053544998169 1.679053544998169 1.679053544998169 0.0 1.679053544998169 34.1871 34.1871 26.3085 26.3085 48.5666 48.5666 DOWN 0.0 1.0 0.0 GO:0097190 5 apoptotic signaling pathway 104 107 10 10 10 7 7 7 155 100 2285 0.62954 0.52753 0.84055 6.54 246273;25513;289388;294515;29496;140942;114851 trib3;pik3r1;g0s2;foxo3;erbb3;ddit4;cdkn1a TRIB3_10079;PIK3R1_32562;G0S2_32729;FOXO3_8662;ERBB3_8571;DDIT4_8450;CDKN1A_8271 48.73773857142857 46.3784 6.24967 39.05086020316002 43.170419108469545 39.369090645765255 33.187807142857146 33.7914 2.44025 29.46364360117438 29.747487912505623 30.13378562760722 95.70877142857144 73.6529 19.0606 79.89354767924449 80.2211891323128 68.94971778631333 4.5 74.27025 108.064;18.7324;46.3784;13.1992;60.9984;87.5421;6.24967 83.8836;11.6701;33.7914;5.6804;41.6036;53.2453;2.44025 143.428;41.5978;73.6529;32.7581;113.972;245.492;19.0606 2 5 2 289388;29496 G0S2_32729;ERBB3_8571 53.6884 53.6884 10.33790114094727 37.697500000000005 37.697500000000005 5.524059595985512 93.81245 93.81245 28.509909021338522 46.3784;60.9984 33.7914;41.6036 73.6529;113.972 5 246273;25513;294515;140942;114851 TRIB3_10079;PIK3R1_32562;FOXO3_8662;DDIT4_8450;CDKN1A_8271 46.757474 18.7324 47.36644529520745 31.38393 11.6701 35.78120319405847 96.4673 41.5978 96.79229043983823 108.064;18.7324;13.1992;87.5421;6.24967 83.8836;11.6701;5.6804;53.2453;2.44025 143.428;41.5978;32.7581;245.492;19.0606 0 Exp 4,2(0.29);Linear,3(0.43);Poly 2,2(0.29) 1.7861779892371448 12.614911913871765 1.522104263305664 2.285230875015259 0.26682073559626257 1.6735800504684448 19.808456488829584 77.66702065402757 11.360834510624006 55.01477977509029 36.52280304354194 154.89473981360095 DOWN 0.2857142857142857 0.7142857142857143 0.0 GO:0009992 6 cellular water homeostasis 1 1 1 1 1 1 1 1 161 0 2385 1.0 0.063604 0.063604 100.0 155423 anxa7 ANXA7_8051 104.64 104.64 104.64 104.64 43.9254 43.9254 43.9254 43.9254 108.689 108.689 108.689 108.689 0.0 104.64 0.0 104.64 104.64 43.9254 108.689 1 0 1 155423 ANXA7_8051 104.64 104.64 43.9254 43.9254 108.689 108.689 104.64 43.9254 108.689 0 0 Exp 3,1(1) 1.5461770296096802 1.5461770296096802 1.5461770296096802 1.5461770296096802 0.0 1.5461770296096802 104.64 104.64 43.9254 43.9254 108.689 108.689 UP 1.0 0.0 0.0 GO:0070995 4 NADPH oxidation 3 3 2 2 1 2 1 1 161 2 2383 0.98844 0.179 0.179 33.33 25256 fmo1 FMO1_32787 65.2792 65.2792 65.2792 65.2792 39.7882 39.7882 39.7882 39.7882 82.9415 82.9415 82.9415 82.9415 0.0 65.2792 0.0 65.2792 65.2792 39.7882 82.9415 1 0 1 25256 FMO1_32787 65.2792 65.2792 39.7882 39.7882 82.9415 82.9415 65.2792 39.7882 82.9415 0 0 Poly 2,1(1) 1.984889268875122 1.984889268875122 1.984889268875122 1.984889268875122 0.0 1.984889268875122 65.2792 65.2792 39.7882 39.7882 82.9415 82.9415 UP 1.0 0.0 0.0 GO:0043543 7 protein acylation 23 23 4 4 3 4 3 3 159 20 2365 0.94591 0.17665 0.17665 13.04 29441;24957;171142 por;glul;ehhadh POR_9531;GLUL_32832;EHHADH_8534 15.845463333333333 12.4414 8.62809 9.393961940365385 14.45528323409699 8.734860245786725 12.284686666666667 8.48981 7.31865 7.609737561968435 11.172055687289221 7.012931318100924 41.685566666666666 35.4303 10.3909 34.845961144633876 41.27865862309571 36.70077417321405 0.5 10.534745000000001 1.5 19.45415 12.4414;26.4669;8.62809 8.48981;21.0456;7.31865 79.2355;35.4303;10.3909 1 2 1 171142 EHHADH_8534 8.62809 8.62809 7.31865 7.31865 10.3909 10.3909 8.62809 7.31865 10.3909 2 29441;24957 POR_9531;GLUL_32832 19.45415 19.45415 9.917526159531928 14.767705 14.767705 8.878284252154245 57.3329 57.3329 30.97495397123295 12.4414;26.4669 8.48981;21.0456 79.2355;35.4303 0 Exp 2,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 5.351439892436288 37.07790541648865 1.9819281101226807 32.73371124267578 17.645780917123073 2.3622660636901855 5.215194681480309 26.475731985186357 3.673457968131494 20.895915365201837 2.2536495744964853 81.11748375883684 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0044267 5 cellular protein metabolic process 443 481 26 26 19 22 16 16 146 465 1920 9.3501E-4 0.9996 0.0017469 3.33 79426;312688;246273;24825;293615;192280;29441;25513;25591;364070;24957;25661;29496;171142;116663;25377 zfp36;usp18;trib3;tf;sirt3;ppp1r3b;por;pik3r1;parp1;iars2;glul;fn1;erbb3;ehhadh;dusp6;ambp ZFP36_10204;USP18_10138;TRIB3_10079;TF_10003;SIRT3_9828;PPP1R3B_9545;POR_9531;PIK3R1_32562;PARP1_9425;IARS2_8858;GLUL_32832;FN1_8655;ERBB3_8571;EHHADH_8534;DUSP6_8506;AMBP_33085 38.69671275 26.7205 0.348134 33.67026197530619 39.78132111559603 30.267247443435107 26.805346999999998 21.4223 0.118102 23.67549836928826 26.850167574203486 20.90176797943515 63.486780625 47.6111 1.15962 48.92822110645573 67.21691544507655 45.514894721120704 0.348134;108.883;108.064;45.1539;2.38018;36.1411;12.4414;18.7324;26.9741;24.7304;26.4669;59.5777;60.9984;8.62809;62.3934;17.2343 0.118102;73.1414;83.8836;28.132;0.56209;27.0588;8.48981;11.6701;21.799;19.8021;21.0456;31.0499;41.6036;7.31865;39.0875;14.1233 1.15962;138.144;143.428;61.5341;8.82917;53.6244;79.2355;41.5978;35.2797;32.7087;35.4303;105.243;113.972;10.3909;133.304;21.9073 7 9 7 312688;24825;293615;25591;364070;29496;171142 USP18_10138;TF_10003;SIRT3_9828;PARP1_9425;IARS2_8858;ERBB3_8571;EHHADH_8534 39.67829571428571 26.9741 36.5465937083252 27.479834285714283 21.799 24.176925820322882 57.26551 35.2797 50.67033627177444 108.883;45.1539;2.38018;26.9741;24.7304;60.9984;8.62809 73.1414;28.132;0.56209;21.799;19.8021;41.6036;7.31865 138.144;61.5341;8.82917;35.2797;32.7087;113.972;10.3909 9 79426;246273;192280;29441;25513;24957;25661;116663;25377 ZFP36_10204;TRIB3_10079;PPP1R3B_9545;POR_9531;PIK3R1_32562;GLUL_32832;FN1_8655;DUSP6_8506;AMBP_33085 37.933259333333325 26.4669 33.50258715068262 26.280745777777778 21.0456 24.736447054682397 68.32554666666667 53.6244 50.02875682255756 0.348134;108.064;36.1411;12.4414;18.7324;26.4669;59.5777;62.3934;17.2343 0.118102;83.8836;27.0588;8.48981;11.6701;21.0456;31.0499;39.0875;14.1233 1.15962;143.428;53.6244;79.2355;41.5978;35.4303;105.243;133.304;21.9073 0 Exp 2,5(0.32);Hill,2(0.13);Linear,3(0.19);Poly 2,4(0.25);Power,2(0.13) 2.1464642089043853 59.731910824775696 1.5209722518920898 32.73371124267578 7.735949960169736 1.7939516305923462 22.198284382099963 55.19514111790003 15.204352799048761 38.406341200951246 39.511952282836695 87.4616089671633 CONFLICT 0.4375 0.5625 0.0 GO:0048511 2 rhythmic process 111 122 12 12 10 9 8 8 154 114 2271 0.62832 0.51915 0.84969 6.56 83516;24516;294515;24890;29496;24330;79431;25698 ppargc1a;jun;foxo3;esr1;erbb3;egr1;bhlhe40;ass1 PPARGC1A_33189;JUN_8938;FOXO3_8662;ESR1_33192;ERBB3_8571;EGR1_8533;BHLHE40_8141;ASS1_33159 30.224852125 25.100450000000002 0.750017 21.59207418335107 30.649415733523384 22.890576925114797 20.241452375 19.645650000000003 0.186019 14.80303368470326 20.668436163110783 15.558164381600116 56.536885 38.31855 4.70178 40.32313747531594 56.99472127276071 42.56930953706469 5.5 50.10895 42.4094;16.4324;13.1992;23.3972;60.9984;0.750017;57.8085;26.8037 26.2988;10.5224;5.6804;18.3088;41.6036;0.186019;38.3491;20.9825 81.7305;39.929;32.7581;31.9156;113.972;4.70178;110.58;36.7081 1 7 1 29496 ERBB3_8571 60.9984 60.9984 41.6036 41.6036 113.972 113.972 60.9984 41.6036 113.972 7 83516;24516;294515;24890;24330;79431;25698 PPARGC1A_33189;JUN_8938;FOXO3_8662;ESR1_33192;EGR1_8533;BHLHE40_8141;ASS1_33159 25.828631 23.3972 19.06665983115187 17.189717 18.3088 12.98958346232176 48.33186857142857 36.7081 35.61750368792823 42.4094;16.4324;13.1992;23.3972;0.750017;57.8085;26.8037 26.2988;10.5224;5.6804;18.3088;0.186019;38.3491;20.9825 81.7305;39.929;32.7581;31.9156;4.70178;110.58;36.7081 0 Exp 2,4(0.5);Exp 4,1(0.13);Hill,1(0.13);Linear,1(0.13);Poly 2,1(0.13) 2.09056123507145 17.566196084022522 1.6013026237487793 4.21828556060791 0.8556760364996955 1.9299678206443787 15.262308091568078 45.187396158431916 9.983473384425169 30.49943136557483 28.594376331436962 84.47939366856303 DOWN 0.125 0.875 0.0 GO:0006012 6 galactose metabolic process 5 5 2 2 2 2 2 2 160 3 2382 0.9977 0.035397 0.035397 40.0 83516;114860 ppargc1a;gale PPARGC1A_33189;GALE_8680 56.7787 56.7787 42.4094 20.321258941807717 51.69049086225928 19.004573673756166 34.79135 34.79135 26.2988 12.010279389131625 31.784114399607507 11.23209148344439 85.3169 85.3169 81.7305 5.071935520094724 84.04694577456154 4.743307121679687 0.0 42.4094 0.0 42.4094 42.4094;71.148 26.2988;43.2839 81.7305;88.9033 0 2 0 2 83516;114860 PPARGC1A_33189;GALE_8680 56.7787 56.7787 20.321258941807717 34.79135 34.79135 12.010279389131625 85.3169 85.3169 5.071935520094724 42.4094;71.148 26.2988;43.2839 81.7305;88.9033 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.8026754714891042 3.6065057516098022 1.7576230764389038 1.8488826751708984 0.06453028111175665 1.8032528758049011 28.614872000000005 84.942528 18.145952 51.436748 78.28755600000001 92.346244 DOWN 0.0 1.0 0.0 GO:0048168 6 regulation of neuronal synaptic plasticity 24 25 2 2 2 2 2 2 160 23 2362 0.79018 0.47902 0.67089 8.0 24330;79431 egr1;bhlhe40 EGR1_8533;BHLHE40_8141 29.2792585 29.2792585 0.750017 40.34644025351734 14.145096281930334 34.2016009719567 19.2675595 19.2675595 0.186019 26.985373366071492 9.14520383563135 22.875449882228075 57.64089 57.64089 4.70178 74.86720734196115 29.557806248185774 63.4647898378414 0.5 29.2792585 0.750017;57.8085 0.186019;38.3491 4.70178;110.58 0 2 0 2 24330;79431 EGR1_8533;BHLHE40_8141 29.2792585 29.2792585 40.34644025351734 19.2675595 19.2675595 26.985373366071492 57.64089 57.64089 74.86720734196115 0.750017;57.8085 0.186019;38.3491 4.70178;110.58 0 Exp 2,1(0.5);Hill,1(0.5) 2.680817860994753 5.922007203102112 1.7037216424942017 4.21828556060791 1.7780651982252176 2.961003601551056 -26.63805483999999 85.19657183999999 -18.132259879999996 56.66737888 -46.11976559999998 161.40154559999996 DOWN 0.0 1.0 0.0 GO:0070372 8 regulation of ERK1 and ERK2 cascade 108 115 9 9 9 8 8 8 154 107 2278 0.69287 0.45042 0.69779 6.96 293615;24516;25675;25661;361969;24890;116663;29184 sirt3;jun;hmgcr;fn1;fga;esr1;dusp6;cd36 SIRT3_9828;JUN_8938;HMGCR_8810;FN1_8655;FGA_8632;ESR1_33192;DUSP6_8506;CD36_8243 30.315208750000004 25.988750000000003 1.63089 24.05176972780615 38.182812626865676 22.242453081418336 20.033265874999998 20.4189 0.56209 15.329798173358567 25.001676087109907 13.730131628692153 54.35532125 39.39005 7.6286 45.11755468978991 65.46297942175485 42.04150028028607 4.5 38.35495 2.38018;16.4324;1.63089;59.5777;28.5803;23.3972;62.3934;48.1296 0.56209;10.5224;0.663137;31.0499;22.529;18.3088;39.0875;37.5433 8.82917;39.929;7.6286;105.243;38.8511;31.9156;133.304;69.1421 2 6 2 293615;29184 SIRT3_9828;CD36_8243 25.254890000000003 25.254890000000003 32.349725117351454 19.052695 19.052695 26.149664367483766 38.985635 38.985635 42.647681796229556 2.38018;48.1296 0.56209;37.5433 8.82917;69.1421 6 24516;25675;25661;361969;24890;116663 JUN_8938;HMGCR_8810;FN1_8655;FGA_8632;ESR1_33192;DUSP6_8506 32.001981666666666 25.988750000000003 24.226530107178306 20.360122833333335 20.4189 13.846660149005176 59.478550000000006 39.39005 48.58063827887608 16.4324;1.63089;59.5777;28.5803;23.3972;62.3934 10.5224;0.663137;31.0499;22.529;18.3088;39.0875 39.929;7.6286;105.243;38.8511;31.9156;133.304 0 Exp 2,3(0.38);Exp 4,1(0.13);Hill,1(0.13);Linear,1(0.13);Poly 2,1(0.13);Power,1(0.13) 1.896173961672514 15.465383052825928 1.5209722518920898 2.6703107357025146 0.420107257523088 1.840501844882965 13.648182665412332 46.98223483458767 9.410257717249069 30.65627403275093 23.09045095572875 85.62019154427125 DOWN 0.25 0.75 0.0 GO:0042127 5 regulation of cell population proliferation 436 466 29 29 22 25 20 20 142 446 1939 0.023754 0.98655 0.045628 4.29 79426;24825;24794;25106;83516;29441;25513;25493;24516;65164;25675;290556;24957;294515;25661;24890;29496;24330;113936;114851 zfp36;tf;serpina3c;rgn;ppargc1a;por;pik3r1;nfkbia;jun;htra1;hmgcr;gnl3;glul;foxo3;fn1;esr1;erbb3;egr1;cpb2;cdkn1a ZFP36_10204;TF_10003;SERPINA3C_32925;RGN_9699;PPARGC1A_33189;POR_9531;PIK3R1_32562;NFKBIA_9307;JUN_8938;HTRA1_8856;HMGCR_8810;GNL3_8735;GLUL_32832;FOXO3_8662;FN1_8655;ESR1_33192;ERBB3_8571;EGR1_8533;CPB2_8369;CDKN1A_8271 29.1057031 24.614400000000003 0.348134 25.88796269561249 32.35523550273406 24.645973422113318 19.447560999999997 19.3731 0.118102 17.446615121604417 21.115927037098476 16.634481202310315 55.49209449999999 40.377300000000005 1.15962 54.56599600537061 58.758518630914246 41.96212233139837 0.348134;45.1539;29.766;77.4407;42.4094;12.4414;18.7324;0.520151;16.4324;33.1323;1.63089;87.6357;26.4669;13.1992;59.5777;23.3972;60.9984;0.750017;25.8316;6.24967 0.118102;28.132;23.347;58.7732;26.2988;8.48981;11.6701;0.160202;10.5224;25.6145;0.663137;54.41;21.0456;5.6804;31.0499;18.3088;41.6036;0.186019;20.4374;2.44025 1.15962;61.5341;40.8256;89.8047;81.7305;79.2355;41.5978;2.88499;39.929;46.6629;7.6286;238.963;35.4303;32.7581;105.243;31.9156;113.972;4.70178;34.8042;19.0606 4 16 4 24825;25106;290556;29496 TF_10003;RGN_9699;GNL3_8735;ERBB3_8571 67.807175 69.21955 18.668203741723506 45.7297 48.0068 13.810433819399002 126.06844999999998 101.88835 78.25438308552863 45.1539;77.4407;87.6357;60.9984 28.132;58.7732;54.41;41.6036 61.5341;89.8047;238.963;113.972 16 79426;24794;83516;29441;25513;25493;24516;65164;25675;24957;294515;25661;24890;24330;113936;114851 ZFP36_10204;SERPINA3C_32925;PPARGC1A_33189;POR_9531;PIK3R1_32562;NFKBIA_9307;JUN_8938;HTRA1_8856;HMGCR_8810;GLUL_32832;FOXO3_8662;FN1_8655;ESR1_33192;EGR1_8533;CPB2_8369;CDKN1A_8271 19.430335125 17.5824 16.73124922432892 12.87702625 11.09625 10.823938919234882 37.848005625 35.11725 29.771524747093927 0.348134;29.766;42.4094;12.4414;18.7324;0.520151;16.4324;33.1323;1.63089;26.4669;13.1992;59.5777;23.3972;0.750017;25.8316;6.24967 0.118102;23.347;26.2988;8.48981;11.6701;0.160202;10.5224;25.6145;0.663137;21.0456;5.6804;31.0499;18.3088;0.186019;20.4374;2.44025 1.15962;40.8256;81.7305;79.2355;41.5978;2.88499;39.929;46.6629;7.6286;35.4303;32.7581;105.243;31.9156;4.70178;34.8042;19.0606 0 Exp 2,4(0.2);Exp 4,4(0.2);Hill,2(0.1);Linear,4(0.2);Poly 2,5(0.25);Power,1(0.05) 1.8864457619541177 38.87519824504852 1.522104263305664 4.21828556060791 0.590505986227031 1.806852400302887 17.759803200271826 40.451602999728166 11.80124479172009 27.09387720827991 31.577492339713835 79.40669666028617 DOWN 0.2 0.8 0.0 GO:0008152 2 metabolic process 1361 1509 181 180 131 160 116 116 46 1393 992 0.99973 5.1038E-4 9.0865E-4 7.69 79426;312688;286954;24856;246273;293688;25357;24825;361510;360268;29573;65192;29500;293615;246074;297784;25106;501907;293656;29676;192280;298490;83516;29441;303612;85253;24651;363465;25513;360722;81819;25591;294103;24314;100359982;24552;24539;24516;54404;50693;306251;25685;364070;65164;63868;29540;289456;24464;25675;24443;171155;113965;85255;81869;57298;29328;24957;499914;24384;114860;294515;314322;25661;84493;25256;246186;361969;304929;308441;295143;24890;29496;65030;25315;116636;171142;24330;291075;29740;116663;298541;140942;25428;266682;65210;24894;25146;25423;83842;497840;113936;291394;362866;81718;114851;29184;54232;361239;25698;155423;25028;25377;25284;65183;362732;50681;192272;170570;50559;24158;25287;170465;313917;312382;25303;296925 zfp36;usp18;ugt2b1;ttr;trib3;tm7sf2;thrsp;tf;sult2a2;sult1e1;slc37a4;slc27a2;slc10a2;sirt3;scd;rrs1;rgn;rgd1559459;rgd1307603;psmb3;ppp1r3b;ppcs;ppargc1a;por;polg2;plg;pklr;pir;pik3r1;pdia5;pax8;parp1;papss2;nqo1;mpc2;me1;lpl;jun;itih4;itih3;itih1;igfbp1;iars2;htra1;hspd1;hsd17b7;hsd17b11;hp;hmgcr;hdc;hadhb;hadh;hacl1;gstm7;gstm3l;gpx4;glul;gins1;gc;gale;foxo3;fos;fn1;fmo3;fmo1;fgl1;fga;f5;exosc5;etfdh;esr1;erbb3;ephx2;ephx1;eif4ebp1;ehhadh;egr1;eci2;eci1;dusp6;dhdds;ddit4;cyp7a1;cyp3a2;cyp2j4;cyp2a1;cyp17a1;ctsc;crot;cps1;cpb2;cndp2;chpt1;cdo1;cdkn1a;cd36;car3;bphl;ass1;anxa7;ampd1;ambp;amacr;aldh3a2;agmo;acox1;acot2;acot12;acot1;acadm;acadl;acaa2;abhd1;abcg2;abcc2;aass ZFP36_10204;USP18_10138;UGT2B10_33303,UGT2B1_33224;TTR_10102;TRIB3_10079;TM7SF2_10031;THRSP_33314;TF_10003;SULT2A2_33196;SULT1E1_32446;SLC37A4_9871;SLC27A2_9860;SLC10A2_9833;SIRT3_9828;SCD1_9787;RRS1_9755;RGN_9699;RGD1559459_9690;RGD1307603_9684;PSMB3_9589;PPP1R3B_9545;PPCS_9540;PPARGC1A_33189;POR_9531;POLG2_9521;PLG_9501;PKLR_9489;PIR_9487;PIK3R1_32562;PDIA5_9451;PAX8_9432;PARP1_9425;PAPSS2_33237;NQO1_33055;MPC2_33219;ME1_9215;LPL_32544;JUN_8938;ITIH4_32725;ITIH3_32422;ITIH1_33132;IGFBP1_32306;IARS2_8858;HTRA1_8856;HSPD1_8849;HSD17B7_8834;HSD17B11_8832;HP_8823;HMGCR_8810;HDC_8788;HADHB_8777;HADH_8776;HACL1_8775;GSTM7_8761;GSTM3_8760;GPX4_32827;GLUL_32832;GINS1_8707;GC_32893;GALE_8680;FOXO3_8662;FOS_8657;FN1_8655;FMO3_8654;FMO1_32787;FGL1_8640;FGA_8632;F5_33079;EXOSC5_32543;ETFDH_8575;ESR1_33192;ERBB3_8571;EPHX2_33282;EPHX1_8567;EIF4EBP1_8550;EHHADH_8534;EGR1_8533;ECI2_8521;ECI1_8520;DUSP6_8506;DHDDS_8467;DDIT4_8450;CYP7A1_8430;CYP3A2_32374;CYP2J4_32580;CYP2A1_32717;CYP17A1_32365;CTSC_32456;CROT_8384;CPS1_32421;CPB2_8369;CNDP2_8341;CHPT1_33298;CDO1_8275;CDKN1A_8271;CD36_8243;CAR3_8196;BPHL_8157;ASS1_33159;ANXA7_8051;AMPD1_32743;AMBP_33085;AMACR_8038;ALDH3A2_8024;AGMO_33265;ACOX1_7973;ACOT2_7969;ACOT12_32718;ACOT1_7968;ACADM_7957;ACADL_32776;ACAA2_7955;ABHD1_7949;ABCG2_32656;ABCC2_32541;AASS_7936 38.8796640086207 33.40015 2.52378E-13 27.120522213803667 39.50262533055938 25.242389862987032 26.50736899137933 25.66675 2.52378E-13 17.38106507145126 26.8412581161772 15.931425755512395 65.44335818965519 46.82425 2.52379E-13 57.01653503927327 65.60396701188036 51.24948094883338 74.5 46.743449999999996 0.348134;108.883;47.47345;46.6406;108.064;82.3097;32.2053;45.1539;54.1932;50.1846;39.7166;7.62189;56.585;2.38018;105.46;60.39;77.4407;2.52378E-13;34.7372;23.7888;36.1411;20.3353;42.4094;12.4414;63.7758;70.7857;23.0963;50.0307;18.7324;107.066;56.8931;26.9741;34.4443;87.2765;46.8463;80.7944;74.2041;16.4324;57.1163;27.1247;98.1741;49.0259;24.7304;33.1323;42.2579;0.977494;22.4334;64.9285;1.63089;24.5745;31.8029;33.3125;17.6275;42.3152;73.0961;45.9204;26.4669;58.9165;42.356;71.148;13.1992;1.28141E-12;59.5777;62.8595;65.2792;15.4757;28.5803;10.6089;41.9329;18.1231;23.3972;60.9984;38.7293;12.4747;83.9001;8.62809;0.750017;10.6467;11.9473;62.3934;47.9438;87.5421;5.72128;12.8505;17.8395;55.3937;49.6922;56.2386;7.4229;31.9826;25.8316;33.544;16.0559;22.9638;6.24967;48.1296;53.9626;12.3152;26.8037;104.64;60.9045;17.2343;2.03774;43.1079;31.5332;23.1906;8.54905;30.3423;31.2018;11.7137;33.4878;26.5872;17.2895;5.21654;46.2316;27.4644 0.118102;73.1414;34.82915;28.5876;83.8836;51.1696;24.3966;28.132;35.5514;36.5009;22.6911;5.49916;35.2796;0.56209;63.7532;43.109;58.7732;2.52378E-13;26.1766;19.2724;27.0588;16.7643;26.2988;8.48981;40.9553;46.2356;17.4625;38.7717;11.6701;61.3361;45.1162;21.799;25.719;60.6992;35.8494;59.856;49.8682;10.5224;39.6402;21.5108;42.9071;32.6883;19.8021;25.6145;23.9469;0.322682;18.1233;41.6103;0.663137;21.0619;25.5756;25.7336;11.195;31.4035;51.4219;34.2198;21.0456;44.7208;26.3722;43.2839;5.6804;1.28141E-12;31.0499;42.5185;39.7882;10.2138;22.529;2.59129;31.7336;14.869;18.3088;41.6036;29.2097;7.00435;42.4185;7.31865;0.186019;8.92359;7.15307;39.0875;36.5688;53.2453;0.985273;7.33176;14.6501;38.7444;35.6654;38.2681;5.75707;24.4836;20.4374;26.3005;10.6021;18.5144;2.44025;37.5433;28.5034;6.6063;20.9825;43.9254;50.0633;14.1233;1.165;31.8774;24.5474;16.2815;7.19676;24.0157;26.858;8.36151;26.6039;21.3695;14.2242;2.73368;31.1788;21.7498 1.15962;138.144;76.47475;63.7146;143.428;209.842;46.6068;61.5341;103.141;80.9788;60.0334;13.3925;116.8;8.82917;422.699;104.942;89.8047;2.52379E-13;50.9085;30.901;53.6244;25.6711;81.7305;79.2355;132.567;150.579;32.9443;73.0083;41.5978;114.259;81.5688;35.2797;51.1014;197.117;69.127;94.0621;155.425;39.929;101.869;36.4819;104.278;89.1623;32.7087;46.6629;102.383;5.49472;29.2247;136.455;7.6286;29.28;42.1484;46.9856;37.6534;64.5991;140.853;70.4292;35.4303;91.837;78.7583;88.9033;32.7581;1.28142E-12;105.243;120.21;82.9415;30.4106;38.8511;37.5078;62.1373;23.0103;31.9156;113.972;57.2113;23.684;107.32;10.3909;4.70178;13.0581;19.001;133.304;71.3742;245.492;22.3625;24.0283;22.6149;96.8569;81.6409;102.888;10.316;45.5891;34.8042;46.311;29.905;30.0179;19.0606;69.1421;77.0288;25.5051;36.7081;108.689;82.6625;21.9073;3.73641;66.3058;43.8459;33.4539;10.4125;41.1025;37.2719;18.9642;45.3228;35.0407;21.8526;11.386;81.7848;37.0295 65 52 64 312688;286954;24856;24825;360268;65192;293615;246074;297784;25106;29676;298490;363465;81819;25591;24314;100359982;24539;364070;63868;289456;24443;171155;113965;85255;81869;57298;29328;499914;25256;308441;295143;29496;65030;25315;116636;171142;291075;29740;298541;266682;65210;24894;25146;83842;291394;362866;29184;361239;155423;25028;25284;65183;362732;50681;192272;170570;50559;24158;25287;170465;313917;312382;296925 USP18_10138;UGT2B10_33303,UGT2B1_33224;TTR_10102;TF_10003;SULT1E1_32446;SLC27A2_9860;SIRT3_9828;SCD1_9787;RRS1_9755;RGN_9699;PSMB3_9589;PPCS_9540;PIR_9487;PAX8_9432;PARP1_9425;NQO1_33055;MPC2_33219;LPL_32544;IARS2_8858;HSPD1_8849;HSD17B11_8832;HDC_8788;HADHB_8777;HADH_8776;HACL1_8775;GSTM7_8761;GSTM3_8760;GPX4_32827;GINS1_8707;FMO1_32787;EXOSC5_32543;ETFDH_8575;ERBB3_8571;EPHX2_33282;EPHX1_8567;EIF4EBP1_8550;EHHADH_8534;ECI2_8521;ECI1_8520;DHDDS_8467;CYP3A2_32374;CYP2J4_32580;CYP2A1_32717;CYP17A1_32365;CROT_8384;CNDP2_8341;CHPT1_33298;CD36_8243;BPHL_8157;ANXA7_8051;AMPD1_32743;AMACR_8038;ALDH3A2_8024;AGMO_33265;ACOX1_7973;ACOT2_7969;ACOT12_32718;ACOT1_7968;ACADM_7957;ACADL_32776;ACAA2_7955;ABHD1_7949;ABCG2_32656;AASS_7936 38.53246624999999 33.40015 25.957617892479412 27.171836562499998 26.017049999999998 16.642061313086423 62.565791093750015 45.816900000000004 60.61666647110992 108.883;47.47345;46.6406;45.1539;50.1846;7.62189;2.38018;105.46;60.39;77.4407;23.7888;20.3353;50.0307;56.8931;26.9741;87.2765;46.8463;74.2041;24.7304;42.2579;22.4334;24.5745;31.8029;33.3125;17.6275;42.3152;73.0961;45.9204;58.9165;65.2792;41.9329;18.1231;60.9984;38.7293;12.4747;83.9001;8.62809;10.6467;11.9473;47.9438;12.8505;17.8395;55.3937;49.6922;7.4229;33.544;16.0559;48.1296;12.3152;104.64;60.9045;2.03774;43.1079;31.5332;23.1906;8.54905;30.3423;31.2018;11.7137;33.4878;26.5872;17.2895;5.21654;27.4644 73.1414;34.82915;28.5876;28.132;36.5009;5.49916;0.56209;63.7532;43.109;58.7732;19.2724;16.7643;38.7717;45.1162;21.799;60.6992;35.8494;49.8682;19.8021;23.9469;18.1233;21.0619;25.5756;25.7336;11.195;31.4035;51.4219;34.2198;44.7208;39.7882;31.7336;14.869;41.6036;29.2097;7.00435;42.4185;7.31865;8.92359;7.15307;36.5688;7.33176;14.6501;38.7444;35.6654;5.75707;26.3005;10.6021;37.5433;6.6063;43.9254;50.0633;1.165;31.8774;24.5474;16.2815;7.19676;24.0157;26.858;8.36151;26.6039;21.3695;14.2242;2.73368;21.7498 138.144;76.47475;63.7146;61.5341;80.9788;13.3925;8.82917;422.699;104.942;89.8047;30.901;25.6711;73.0083;81.5688;35.2797;197.117;69.127;155.425;32.7087;102.383;29.2247;29.28;42.1484;46.9856;37.6534;64.5991;140.853;70.4292;91.837;82.9415;62.1373;23.0103;113.972;57.2113;23.684;107.32;10.3909;13.0581;19.001;71.3742;24.0283;22.6149;96.8569;81.6409;10.316;46.311;29.905;69.1421;25.5051;108.689;82.6625;3.73641;66.3058;43.8459;33.4539;10.4125;41.1025;37.2719;18.9642;45.3228;35.0407;21.8526;11.386;37.0295 52 79426;246273;293688;25357;361510;29573;29500;501907;293656;192280;83516;29441;303612;85253;24651;25513;360722;294103;24552;24516;54404;50693;306251;25685;65164;29540;24464;25675;24957;24384;114860;294515;314322;25661;84493;246186;361969;304929;24890;24330;116663;140942;25428;25423;497840;113936;81718;114851;54232;25698;25377;25303 ZFP36_10204;TRIB3_10079;TM7SF2_10031;THRSP_33314;SULT2A2_33196;SLC37A4_9871;SLC10A2_9833;RGD1559459_9690;RGD1307603_9684;PPP1R3B_9545;PPARGC1A_33189;POR_9531;POLG2_9521;PLG_9501;PKLR_9489;PIK3R1_32562;PDIA5_9451;PAPSS2_33237;ME1_9215;JUN_8938;ITIH4_32725;ITIH3_32422;ITIH1_33132;IGFBP1_32306;HTRA1_8856;HSD17B7_8834;HP_8823;HMGCR_8810;GLUL_32832;GC_32893;GALE_8680;FOXO3_8662;FOS_8657;FN1_8655;FMO3_8654;FGL1_8640;FGA_8632;F5_33079;ESR1_33192;EGR1_8533;DUSP6_8506;DDIT4_8450;CYP7A1_8430;CTSC_32456;CPS1_32421;CPB2_8369;CDO1_8275;CDKN1A_8271;CAR3_8196;ASS1_33159;AMBP_33085;ABCC2_32541 39.3069843269231 33.7883 28.737702813527104 25.689562750000032 25.04905 18.3806492895622 68.98497923076927 51.004949999999994 52.61470467467161 0.348134;108.064;82.3097;32.2053;54.1932;39.7166;56.585;2.52378E-13;34.7372;36.1411;42.4094;12.4414;63.7758;70.7857;23.0963;18.7324;107.066;34.4443;80.7944;16.4324;57.1163;27.1247;98.1741;49.0259;33.1323;0.977494;64.9285;1.63089;26.4669;42.356;71.148;13.1992;1.28141E-12;59.5777;62.8595;15.4757;28.5803;10.6089;23.3972;0.750017;62.3934;87.5421;5.72128;56.2386;31.9826;25.8316;22.9638;6.24967;53.9626;26.8037;17.2343;46.2316 0.118102;83.8836;51.1696;24.3966;35.5514;22.6911;35.2796;2.52378E-13;26.1766;27.0588;26.2988;8.48981;40.9553;46.2356;17.4625;11.6701;61.3361;25.719;59.856;10.5224;39.6402;21.5108;42.9071;32.6883;25.6145;0.322682;41.6103;0.663137;21.0456;26.3722;43.2839;5.6804;1.28141E-12;31.0499;42.5185;10.2138;22.529;2.59129;18.3088;0.186019;39.0875;53.2453;0.985273;38.2681;24.4836;20.4374;18.5144;2.44025;28.5034;20.9825;14.1233;31.1788 1.15962;143.428;209.842;46.6068;103.141;60.0334;116.8;2.52379E-13;50.9085;53.6244;81.7305;79.2355;132.567;150.579;32.9443;41.5978;114.259;51.1014;94.0621;39.929;101.869;36.4819;104.278;89.1623;46.6629;5.49472;136.455;7.6286;35.4303;78.7583;88.9033;32.7581;1.28142E-12;105.243;120.21;30.4106;38.8511;37.5078;31.9156;4.70178;133.304;245.492;22.3625;102.888;45.5891;34.8042;30.0179;19.0606;77.0288;36.7081;21.9073;81.7848 0 Exp 2,47(0.41);Exp 3,6(0.06);Exp 4,7(0.06);Hill,11(0.1);Linear,26(0.23);Poly 2,17(0.15);Power,3(0.03) 2.2140865978387776 651.0222568511963 1.5074360370635986 344.14306640625 31.765213491329416 1.8086696863174438 33.94423255547077 43.81509546177059 23.34433789018525 29.670400092573402 55.067407528969596 75.81930885034069 CONFLICT 0.5517241379310345 0.4482758620689655 0.0 GO:0030308 6 negative regulation of cell growth 49 53 3 3 2 2 2 2 160 51 2334 0.33381 0.86151 0.77248 3.77 114851;25373 cdkn1a;ahsg CDKN1A_8271;AHSG_8003 9.325835 9.325835 6.24967 4.350354263097432 8.020492674004277 3.939256914492646 6.370775 6.370775 2.44025 5.558601762246508 4.7028928656267315 5.033328115961341 17.24205 17.24205 15.4235 2.5718180738536076 18.013734967139126 2.3287878452068025 6.24967;12.402 2.44025;10.3013 19.0606;15.4235 0 2 0 2 114851;25373 CDKN1A_8271;AHSG_8003 9.325835 9.325835 4.350354263097432 6.370775 6.370775 5.558601762246508 17.24205 17.24205 2.5718180738536076 6.24967;12.402 2.44025;10.3013 19.0606;15.4235 0 Exp 2,1(0.5);Exp 4,1(0.5) 2.2853838069030963 4.953524351119995 1.522104263305664 3.431420087814331 1.3500901669368626 2.4767621755599976 3.296551600000001 15.355118399999999 -1.3330539999999989 14.074603999999999 13.677692 20.806407999999998 DOWN 0.0 1.0 0.0 GO:0051222 6 positive regulation of protein transport 131 141 15 14 10 13 9 9 153 132 2253 0.59219 0.54791 1.0 6.38 293615;25513;100359982;24539;63868;24957;361969;65210;29184 sirt3;pik3r1;mpc2;lpl;hspd1;glul;fga;cyp2j4;cd36 SIRT3_9828;PIK3R1_32562;MPC2_33219;LPL_32544;HSPD1_8849;GLUL_32832;FGA_8632;CYP2J4_32580;CD36_8243 33.937464444444444 28.5803 2.38018 21.299634748485186 37.12561646958844 22.097831364433674 24.184965555555557 22.529 0.56209 14.968145114448138 26.59394118194905 15.190668941426708 60.37781888888888 41.5978 8.82917 45.37831441122744 65.79820023292113 48.87267788711644 6.5 47.48795 2.38018;18.7324;46.8463;74.2041;42.2579;26.4669;28.5803;17.8395;48.1296 0.56209;11.6701;35.8494;49.8682;23.9469;21.0456;22.529;14.6501;37.5433 8.82917;41.5978;69.127;155.425;102.383;35.4303;38.8511;22.6149;69.1421 6 3 6 293615;100359982;24539;63868;65210;29184 SIRT3_9828;MPC2_33219;LPL_32544;HSPD1_8849;CYP2J4_32580;CD36_8243 38.60959666666667 44.552099999999996 25.229823929533616 27.06999833333333 29.89815 17.738110173736573 71.25352833333334 69.13454999999999 53.526400179003424 2.38018;46.8463;74.2041;42.2579;17.8395;48.1296 0.56209;35.8494;49.8682;23.9469;14.6501;37.5433 8.82917;69.127;155.425;102.383;22.6149;69.1421 3 25513;24957;361969 PIK3R1_32562;GLUL_32832;FGA_8632 24.593199999999996 26.4669 5.184433177310721 18.4149 21.0456 5.888069647176403 38.6264 38.8511 3.089883756713264 18.7324;26.4669;28.5803 11.6701;21.0456;22.529 41.5978;35.4303;38.8511 0 Exp 2,3(0.34);Exp 3,1(0.12);Hill,1(0.12);Linear,3(0.34);Poly 2,1(0.12) 2.0489300133686243 19.31063437461853 1.5209722518920898 3.8079800605773926 0.7473237527224809 1.9223796129226685 20.021703075434125 47.85322581345478 14.4057774141161 33.964153696995005 30.730653473553637 90.02498430422415 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0006541 9 glutamine metabolic process 8 8 3 3 2 3 2 2 160 6 2379 0.98885 0.087405 0.087405 25.0 24957;497840 glul;cps1 GLUL_32832;CPS1_32421 29.22475 29.22475 26.4669 3.9001888729906082 29.60776939163498 3.862391168209509 22.7646 22.7646 21.0456 2.431033113719314 23.003340444266563 2.4074733644513038 40.5097 40.5097 35.4303 7.183356368717921 41.21514398639184 7.11374066747776 0.0 26.4669 0.0 26.4669 26.4669;31.9826 21.0456;24.4836 35.4303;45.5891 0 2 0 2 24957;497840 GLUL_32832;CPS1_32421 29.22475 29.22475 3.9001888729906082 22.7646 22.7646 2.431033113719314 40.5097 40.5097 7.183356368717921 26.4669;31.9826 21.0456;24.4836 35.4303;45.5891 0 Exp 2,1(0.5);Linear,1(0.5) 2.0771666019644917 4.188741564750671 1.8264755010604858 2.3622660636901855 0.37886114013121625 2.0943707823753357 23.819364 34.630136 19.395360000000004 26.13384 30.554076000000002 50.465324 DOWN 0.0 1.0 0.0 GO:0030193 5 regulation of blood coagulation 45 46 5 5 5 5 5 5 157 41 2344 0.93172 0.16478 0.21209 10.87 85253;288001;361969;113936;29184 plg;kng1;fga;cpb2;cd36 PLG_9501;KNG1L1_34113;FGA_8632;CPB2_8369;CD36_8243 39.53854 28.5803 24.3655 19.927215628958297 46.16390839286978 19.578208055404243 29.25666 22.529 19.538 11.983800672491189 33.62678187734314 11.421383031106144 65.10462 38.8511 32.1467 50.03937983335725 78.9606787507958 51.81591644154256 1.5 27.20595 3.5 59.45765 70.7857;24.3655;28.5803;25.8316;48.1296 46.2356;19.538;22.529;20.4374;37.5433 150.579;32.1467;38.8511;34.8042;69.1421 1 4 1 29184 CD36_8243 48.1296 48.1296 37.5433 37.5433 69.1421 69.1421 48.1296 37.5433 69.1421 4 85253;288001;361969;113936 PLG_9501;KNG1L1_34113;FGA_8632;CPB2_8369 37.390775000000005 27.20595 22.331724825066694 27.185000000000002 21.4832 12.762058495399549 64.09525000000001 36.827650000000006 57.72169315052473 70.7857;24.3655;28.5803;25.8316 46.2356;19.538;22.529;20.4374 150.579;32.1467;38.8511;34.8042 0 Exp 2,2(0.4);Linear,3(0.6) 1.8781532294387269 9.681173086166382 1.5254690647125244 2.6703107357025146 0.5476387461370176 1.5630855560302734 22.071565370530383 57.00551462946963 18.7523955704608 39.76092442953921 21.243169695147003 108.96607030485302 DOWN 0.2 0.8 0.0 GO:0070427 8 nucleotide-binding oligomerization domain containing 1 signaling pathway 1 1 1 1 1 1 1 1 161 0 2385 1.0 0.063604 0.063604 100.0 25493 nfkbia NFKBIA_9307 0.520151 0.520151 0.520151 0.520151 0.160202 0.160202 0.160202 0.160202 2.88499 2.88499 2.88499 2.88499 0.0 0.520151 0.0 0.520151 0.520151 0.160202 2.88499 0 1 0 1 25493 NFKBIA_9307 0.520151 0.520151 0.160202 0.160202 2.88499 2.88499 0.520151 0.160202 2.88499 0 Exp 4,1(1) 1.8546061515808105 1.8546061515808105 1.8546061515808105 1.8546061515808105 0.0 1.8546061515808105 0.520151 0.520151 0.160202 0.160202 2.88499 2.88499 DOWN 0.0 1.0 0.0 GO:1901698 4 response to nitrogen compound 416 438 58 57 44 53 40 40 122 398 1987 0.9955 0.007866 0.012899 9.13 24522;286954;246273;24825;25351;29482;83516;29441;24651;25513;25591;24314;25493;58954;24516;81678;63868;24471;29540;24464;113965;81869;294515;314322;25661;361969;29496;24330;25146;83842;497840;81718;114851;29184;25698;65054;25373;312382;140668;25303 zfp354a;ugt2b1;trib3;tf;slc2a2;slc1a2;ppargc1a;por;pklr;pik3r1;parp1;nqo1;nfkbia;klf6;jun;itpr2;hspd1;hspb1;hsd17b7;hp;hadh;gstm7;foxo3;fos;fn1;fga;erbb3;egr1;cyp17a1;crot;cps1;cdo1;cdkn1a;cd36;ass1;aqp9;ahsg;abcg2;abcc3;abcc2 ZFP354A_10203;UGT2B10_33303,UGT2B1_33224;TRIB3_10079;TF_10003;SLC2A2_9863;SLC1A2_33059;PPARGC1A_33189;POR_9531;PKLR_9489;PIK3R1_32562;PARP1_9425;NQO1_33055;NFKBIA_9307;KLF6_8969;JUN_8938;ITPR2_8931;HSPD1_8849;HSPB1_8847;HSD17B7_8834;HP_8823;HADH_8776;GSTM7_8761;FOXO3_8662;FOS_8657;FN1_8655;FGA_8632;ERBB3_8571;EGR1_8533;CYP17A1_32365;CROT_8384;CPS1_32421;CDO1_8275;CDKN1A_8271;CD36_8243;ASS1_33159;AQP9_32709;AHSG_8003;ABCG2_32656;ABCC3_7941;ABCC2_32541 32.04471372500003 28.15595 1.28141E-12 25.593200430511903 33.038298749082415 24.217983690055885 22.498150825000035 22.2331 1.28141E-12 18.32622057712461 22.99647732871491 16.97936759762568 54.88907525000003 42.9637 1.28142E-12 43.57093777234111 55.381775270254444 39.122226405640745 20.5 29.167900000000003 0.834827;47.47345;108.064;45.1539;29.7555;13.3235;42.4094;12.4414;23.0963;18.7324;26.9741;87.2765;0.520151;18.9476;16.4324;31.8111;42.2579;89.1011;0.977494;64.9285;33.3125;42.3152;13.1992;1.28141E-12;59.5777;28.5803;60.9984;0.750017;49.6922;7.4229;31.9826;22.9638;6.24967;48.1296;26.8037;27.7316;12.402;5.21654;37.7175;46.2316 0.27095;34.82915;83.8836;28.132;23.3399;9.10952;26.2988;8.48981;17.4625;11.6701;21.799;60.6992;0.160202;11.6941;10.5224;24.7342;23.9469;60.3265;0.322682;41.6103;25.7336;31.4035;5.6804;1.28141E-12;31.0499;22.529;41.6036;0.186019;35.6654;5.75707;24.4836;18.5144;2.44025;37.5433;20.9825;21.9372;10.3013;2.73368;30.9007;31.1788 2.99857;76.47475;143.428;61.5341;40.808;24.6773;81.7305;79.2355;32.9443;41.5978;35.2797;197.117;2.88499;45.5481;39.929;44.3296;102.383;106.138;5.49472;136.455;46.9856;64.5991;32.7581;1.28142E-12;105.243;38.8511;113.972;4.70178;81.6409;10.316;45.5891;30.0179;19.0606;69.1421;36.7081;37.4625;15.4235;11.386;48.9329;81.7848 14 27 13 286954;24825;25591;24314;63868;113965;81869;29496;25146;83842;29184;312382;140668 UGT2B10_33303,UGT2B1_33224;TF_10003;PARP1_9425;NQO1_33055;HSPD1_8849;HADH_8776;GSTM7_8761;ERBB3_8571;CYP17A1_32365;CROT_8384;CD36_8243;ABCG2_32656;ABCC3_7941 41.07236076923077 42.3152 21.222465324925714 29.288238461538466 30.9007 14.839020421034553 70.75101153846153 64.5991 48.810322024786906 47.47345;45.1539;26.9741;87.2765;42.2579;33.3125;42.3152;60.9984;49.6922;7.4229;48.1296;5.21654;37.7175 34.82915;28.132;21.799;60.6992;23.9469;25.7336;31.4035;41.6036;35.6654;5.75707;37.5433;2.73368;30.9007 76.47475;61.5341;35.2797;197.117;102.383;46.9856;64.5991;113.972;81.6409;10.316;69.1421;11.386;48.9329 27 24522;246273;25351;29482;83516;29441;24651;25513;25493;58954;24516;81678;24471;29540;24464;294515;314322;25661;361969;24330;497840;81718;114851;25698;65054;25373;25303 ZFP354A_10203;TRIB3_10079;SLC2A2_9863;SLC1A2_33059;PPARGC1A_33189;POR_9531;PKLR_9489;PIK3R1_32562;NFKBIA_9307;KLF6_8969;JUN_8938;ITPR2_8931;HSPB1_8847;HSD17B7_8834;HP_8823;FOXO3_8662;FOS_8657;FN1_8655;FGA_8632;EGR1_8533;CPS1_32421;CDO1_8275;CDKN1A_8271;ASS1_33159;AQP9_32709;AHSG_8003;ABCC2_32541 27.698068851851897 22.9638 26.72592301026066 19.22884937037042 17.4625 19.183177731520928 47.25184666666672 38.8511 39.51806712113648 0.834827;108.064;29.7555;13.3235;42.4094;12.4414;23.0963;18.7324;0.520151;18.9476;16.4324;31.8111;89.1011;0.977494;64.9285;13.1992;1.28141E-12;59.5777;28.5803;0.750017;31.9826;22.9638;6.24967;26.8037;27.7316;12.402;46.2316 0.27095;83.8836;23.3399;9.10952;26.2988;8.48981;17.4625;11.6701;0.160202;11.6941;10.5224;24.7342;60.3265;0.322682;41.6103;5.6804;1.28141E-12;31.0499;22.529;0.186019;24.4836;18.5144;2.44025;20.9825;21.9372;10.3013;31.1788 2.99857;143.428;40.808;24.6773;81.7305;79.2355;32.9443;41.5978;2.88499;45.5481;39.929;44.3296;106.138;5.49472;136.455;32.7581;1.28142E-12;105.243;38.8511;4.70178;45.5891;30.0179;19.0606;36.7081;37.4625;15.4235;81.7848 0 Exp 2,13(0.32);Exp 3,1(0.03);Exp 4,5(0.13);Hill,3(0.08);Linear,9(0.22);Poly 2,9(0.22);Power,1(0.03) 2.0062520537889226 87.15986216068268 1.5074360370635986 5.963563919067383 0.9125285572700546 1.8264755010604858 24.113298739585314 39.97612871041474 16.818796228216826 28.177505421783238 41.38630174129406 68.391848758706 DOWN 0.325 0.675 0.0 GO:0071548 6 response to dexamethasone 48 52 13 13 10 11 8 8 154 44 2341 0.99532 0.015315 0.015315 15.38 25513;294515;116636;140942;497840;25698;312382;25303 pik3r1;foxo3;eif4ebp1;ddit4;cps1;ass1;abcg2;abcc2 PIK3R1_32562;FOXO3_8662;EIF4EBP1_8550;DDIT4_8450;CPS1_32421;ASS1_33159;ABCG2_32656;ABCC2_32541 39.20103 29.39315 5.21654 31.25951257026616 36.66222015377904 30.834431616088683 24.04911 22.73305 2.73368 17.709054621720657 22.408147862907626 16.531917645453348 75.3294875 43.593450000000004 11.386 75.05746960049892 60.669269364161856 58.03689179529333 1.5 15.965799999999998 4.5 39.1071 18.7324;13.1992;83.9001;87.5421;31.9826;26.8037;5.21654;46.2316 11.6701;5.6804;42.4185;53.2453;24.4836;20.9825;2.73368;31.1788 41.5978;32.7581;107.32;245.492;45.5891;36.7081;11.386;81.7848 2 6 2 116636;312382 EIF4EBP1_8550;ABCG2_32656 44.558319999999995 44.558319999999995 55.637678843898584 22.57609 22.57609 28.061405332167524 59.352999999999994 59.352999999999994 67.83558194635026 83.9001;5.21654 42.4185;2.73368 107.32;11.386 6 25513;294515;140942;497840;25698;25303 PIK3R1_32562;FOXO3_8662;DDIT4_8450;CPS1_32421;ASS1_33159;ABCC2_32541 37.41526666666667 29.39315 27.085102028212233 24.540116666666666 22.73305 16.745421695665552 80.65498333333333 43.593450000000004 82.6474903199224 18.7324;13.1992;87.5421;31.9826;26.8037;46.2316 11.6701;5.6804;53.2453;24.4836;20.9825;31.1788 41.5978;32.7581;245.492;45.5891;36.7081;81.7848 0 Exp 2,3(0.38);Exp 3,1(0.13);Exp 4,2(0.25);Linear,1(0.13);Poly 2,1(0.13) 1.7534764104462937 14.076298236846924 1.5074360370635986 1.9883413314819336 0.15517588354871312 1.7500277757644653 17.539292951279105 60.8627670487209 11.777361240806789 36.320858759193214 23.31731468144838 127.34166031855162 DOWN 0.25 0.75 0.0 GO:0055085 4 transmembrane transport 188 198 24 23 18 21 15 15 147 183 2202 0.81346 0.27333 0.44827 7.58 170698;29573;25351;361074;29482;29500;100359982;81678;63868;24384;170945;65054;312382;140668;25303 slco1a2;slc37a4;slc2a2;slc25a30;slc1a2;slc10a2;mpc2;itpr2;hspd1;gc;chrna2;aqp9;abcg2;abcc3;abcc2 SLCO1A2_9886;SLC37A4_9871;SLC2A2_9863;SLC25A30_9856;SLC1A2_33059;SLC10A2_9833;MPC2_33219;ITPR2_8931;HSPD1_8849;GC_32893;CHRNA2_32401;AQP9_32709;ABCG2_32656;ABCC3_7941;ABCC2_32541 41.74336266666667 42.2579 5.21654 22.287010781729045 38.52977772032263 17.221735360463477 29.847739999999998 26.3722 2.73368 17.344542842653095 27.13413337273342 13.297939910564372 66.50841333333334 62.472 11.386 33.54548453560303 63.301192642687106 30.266051852238952 8.5 44.293800000000005 104.197;39.7166;29.7555;53.013;13.3235;56.585;46.8463;31.8111;42.2579;42.356;49.3913;27.7316;5.21654;37.7175;46.2316 80.3101;22.6911;23.3399;37.4804;9.10952;35.2796;35.8494;24.7342;23.9469;26.3722;41.8524;21.9372;2.73368;30.9007;31.1788 128.412;60.0334;40.808;90.2594;24.6773;116.8;69.127;44.3296;102.383;78.7583;62.472;37.4625;11.386;48.9329;81.7848 6 9 6 361074;100359982;63868;170945;312382;140668 SLC25A30_9856;MPC2_33219;HSPD1_8849;CHRNA2_32401;ABCG2_32656;ABCC3_7941 39.07375666666667 44.552099999999996 17.43247519049623 28.793913333333336 33.37505 14.16211048140307 64.09338333333332 65.7995 32.20754528394966 53.013;46.8463;42.2579;49.3913;5.21654;37.7175 37.4804;35.8494;23.9469;41.8524;2.73368;30.9007 90.2594;69.127;102.383;62.472;11.386;48.9329 9 170698;29573;25351;29482;29500;81678;24384;65054;25303 SLCO1A2_9886;SLC37A4_9871;SLC2A2_9863;SLC1A2_33059;SLC10A2_9833;ITPR2_8931;GC_32893;AQP9_32709;ABCC2_32541 43.5231 39.7166 25.892151262255133 30.550291111111115 24.7342 19.992911109371022 68.11843333333334 60.0334 36.24437869018448 104.197;39.7166;29.7555;13.3235;56.585;31.8111;42.356;27.7316;46.2316 80.3101;22.6911;23.3399;9.10952;35.2796;24.7342;26.3722;21.9372;31.1788 128.412;60.0334;40.808;24.6773;116.8;44.3296;78.7583;37.4625;81.7848 0 Exp 2,5(0.34);Exp 3,2(0.14);Exp 4,1(0.07);Linear,4(0.27);Poly 2,3(0.2) 1.9445941903577917 30.220357418060303 1.5074360370635986 3.648852586746216 0.615678134562482 1.8171201944351196 30.46457904500079 53.02214628833255 21.070190257915606 38.62528974208439 49.53205588161174 83.48477078505493 DOWN 0.4 0.6 0.0 GO:0003002 4 regionalization 36 40 2 2 2 2 2 2 160 38 2347 0.527 0.73412 1.0 5.0 81819;79431 pax8;bhlhe40 PAX8_9432;BHLHE40_8141 57.3508 57.3508 56.8931 0.6472855474988141 57.067860637356155 0.508791916341496 41.73265 41.73265 38.3491 4.785062298967477 43.82428093832989 3.761247298522456 96.0744 96.0744 81.5688 20.51401625035919 87.1073796400118 16.124824167944148 1.0 57.8085 56.8931;57.8085 45.1162;38.3491 81.5688;110.58 1 1 1 81819 PAX8_9432 56.8931 56.8931 45.1162 45.1162 81.5688 81.5688 56.8931 45.1162 81.5688 1 79431 BHLHE40_8141 57.8085 57.8085 38.3491 38.3491 110.58 110.58 57.8085 38.3491 110.58 0 Exp 2,2(1) 1.7277898083856014 3.455919623374939 1.7037216424942017 1.7521979808807373 0.0342779476002131 1.7279598116874695 56.45370799999999 58.24789200000001 35.100892 48.364408 67.643424 124.505376 CONFLICT 0.5 0.5 0.0 GO:0044237 3 cellular metabolic process 1201 1328 157 156 111 140 98 98 64 1230 1155 0.98898 0.016779 0.028381 7.38 79426;312688;286954;24856;246273;24825;360268;29573;65192;29500;293615;246074;297784;25106;501907;293656;29676;192280;298490;83516;29441;303612;24651;25513;81819;25591;294103;24314;100359982;24552;24539;24516;54404;50693;306251;364070;63868;29540;289456;25675;24443;171155;113965;85255;81869;57298;29328;24957;499914;294515;314322;25661;84493;25256;308441;295143;24890;29496;65030;25315;116636;171142;24330;291075;29740;116663;298541;140942;25428;266682;65210;24894;25146;83842;497840;362866;81718;114851;29184;54232;25698;155423;25028;25377;25284;65183;362732;50681;192272;170570;50559;24158;25287;170465;313917;312382;25303;296925 zfp36;usp18;ugt2b1;ttr;trib3;tf;sult1e1;slc37a4;slc27a2;slc10a2;sirt3;scd;rrs1;rgn;rgd1559459;rgd1307603;psmb3;ppp1r3b;ppcs;ppargc1a;por;polg2;pklr;pik3r1;pax8;parp1;papss2;nqo1;mpc2;me1;lpl;jun;itih4;itih3;itih1;iars2;hspd1;hsd17b7;hsd17b11;hmgcr;hdc;hadhb;hadh;hacl1;gstm7;gstm3l;gpx4;glul;gins1;foxo3;fos;fn1;fmo3;fmo1;exosc5;etfdh;esr1;erbb3;ephx2;ephx1;eif4ebp1;ehhadh;egr1;eci2;eci1;dusp6;dhdds;ddit4;cyp7a1;cyp3a2;cyp2j4;cyp2a1;cyp17a1;crot;cps1;chpt1;cdo1;cdkn1a;cd36;car3;ass1;anxa7;ampd1;ambp;amacr;aldh3a2;agmo;acox1;acot2;acot12;acot1;acadm;acadl;acaa2;abhd1;abcg2;abcc2;aass ZFP36_10204;USP18_10138;UGT2B10_33303,UGT2B1_33224;TTR_10102;TRIB3_10079;TF_10003;SULT1E1_32446;SLC37A4_9871;SLC27A2_9860;SLC10A2_9833;SIRT3_9828;SCD1_9787;RRS1_9755;RGN_9699;RGD1559459_9690;RGD1307603_9684;PSMB3_9589;PPP1R3B_9545;PPCS_9540;PPARGC1A_33189;POR_9531;POLG2_9521;PKLR_9489;PIK3R1_32562;PAX8_9432;PARP1_9425;PAPSS2_33237;NQO1_33055;MPC2_33219;ME1_9215;LPL_32544;JUN_8938;ITIH4_32725;ITIH3_32422;ITIH1_33132;IARS2_8858;HSPD1_8849;HSD17B7_8834;HSD17B11_8832;HMGCR_8810;HDC_8788;HADHB_8777;HADH_8776;HACL1_8775;GSTM7_8761;GSTM3_8760;GPX4_32827;GLUL_32832;GINS1_8707;FOXO3_8662;FOS_8657;FN1_8655;FMO3_8654;FMO1_32787;EXOSC5_32543;ETFDH_8575;ESR1_33192;ERBB3_8571;EPHX2_33282;EPHX1_8567;EIF4EBP1_8550;EHHADH_8534;EGR1_8533;ECI2_8521;ECI1_8520;DUSP6_8506;DHDDS_8467;DDIT4_8450;CYP7A1_8430;CYP3A2_32374;CYP2J4_32580;CYP2A1_32717;CYP17A1_32365;CROT_8384;CPS1_32421;CHPT1_33298;CDO1_8275;CDKN1A_8271;CD36_8243;CAR3_8196;ASS1_33159;ANXA7_8051;AMPD1_32743;AMBP_33085;AMACR_8038;ALDH3A2_8024;AGMO_33265;ACOX1_7973;ACOT2_7969;ACOT12_32718;ACOT1_7968;ACADM_7957;ACADL_32776;ACAA2_7955;ABHD1_7949;ABCG2_32656;ABCC2_32541;AASS_7936 37.451688010204094 31.89275 2.52378E-13 27.22599379278063 38.714244643431314 25.85253957882672 25.7232470714286 24.5155 2.52378E-13 17.662694249037745 26.307572696222092 16.344869555970863 62.63034540816328 45.45595 2.52379E-13 58.06668287129773 63.159685151197024 51.68052678881878 65.5 46.743449999999996 0.348134;108.883;47.47345;46.6406;108.064;45.1539;50.1846;39.7166;7.62189;56.585;2.38018;105.46;60.39;77.4407;2.52378E-13;34.7372;23.7888;36.1411;20.3353;42.4094;12.4414;63.7758;23.0963;18.7324;56.8931;26.9741;34.4443;87.2765;46.8463;80.7944;74.2041;16.4324;57.1163;27.1247;98.1741;24.7304;42.2579;0.977494;22.4334;1.63089;24.5745;31.8029;33.3125;17.6275;42.3152;73.0961;45.9204;26.4669;58.9165;13.1992;1.28141E-12;59.5777;62.8595;65.2792;41.9329;18.1231;23.3972;60.9984;38.7293;12.4747;83.9001;8.62809;0.750017;10.6467;11.9473;62.3934;47.9438;87.5421;5.72128;12.8505;17.8395;55.3937;49.6922;7.4229;31.9826;16.0559;22.9638;6.24967;48.1296;53.9626;26.8037;104.64;60.9045;17.2343;2.03774;43.1079;31.5332;23.1906;8.54905;30.3423;31.2018;11.7137;33.4878;26.5872;17.2895;5.21654;46.2316;27.4644 0.118102;73.1414;34.82915;28.5876;83.8836;28.132;36.5009;22.6911;5.49916;35.2796;0.56209;63.7532;43.109;58.7732;2.52378E-13;26.1766;19.2724;27.0588;16.7643;26.2988;8.48981;40.9553;17.4625;11.6701;45.1162;21.799;25.719;60.6992;35.8494;59.856;49.8682;10.5224;39.6402;21.5108;42.9071;19.8021;23.9469;0.322682;18.1233;0.663137;21.0619;25.5756;25.7336;11.195;31.4035;51.4219;34.2198;21.0456;44.7208;5.6804;1.28141E-12;31.0499;42.5185;39.7882;31.7336;14.869;18.3088;41.6036;29.2097;7.00435;42.4185;7.31865;0.186019;8.92359;7.15307;39.0875;36.5688;53.2453;0.985273;7.33176;14.6501;38.7444;35.6654;5.75707;24.4836;10.6021;18.5144;2.44025;37.5433;28.5034;20.9825;43.9254;50.0633;14.1233;1.165;31.8774;24.5474;16.2815;7.19676;24.0157;26.858;8.36151;26.6039;21.3695;14.2242;2.73368;31.1788;21.7498 1.15962;138.144;76.47475;63.7146;143.428;61.5341;80.9788;60.0334;13.3925;116.8;8.82917;422.699;104.942;89.8047;2.52379E-13;50.9085;30.901;53.6244;25.6711;81.7305;79.2355;132.567;32.9443;41.5978;81.5688;35.2797;51.1014;197.117;69.127;94.0621;155.425;39.929;101.869;36.4819;104.278;32.7087;102.383;5.49472;29.2247;7.6286;29.28;42.1484;46.9856;37.6534;64.5991;140.853;70.4292;35.4303;91.837;32.7581;1.28142E-12;105.243;120.21;82.9415;62.1373;23.0103;31.9156;113.972;57.2113;23.684;107.32;10.3909;4.70178;13.0581;19.001;133.304;71.3742;245.492;22.3625;24.0283;22.6149;96.8569;81.6409;10.316;45.5891;29.905;30.0179;19.0606;69.1421;77.0288;36.7081;108.689;82.6625;21.9073;3.73641;66.3058;43.8459;33.4539;10.4125;41.1025;37.2719;18.9642;45.3228;35.0407;21.8526;11.386;81.7848;37.0295 62 37 61 312688;286954;24856;24825;360268;65192;293615;246074;297784;25106;29676;298490;81819;25591;24314;100359982;24539;364070;63868;289456;24443;171155;113965;85255;81869;57298;29328;499914;25256;308441;295143;29496;65030;25315;116636;171142;291075;29740;298541;266682;65210;24894;25146;83842;362866;29184;155423;25028;25284;65183;362732;50681;192272;170570;50559;24158;25287;170465;313917;312382;296925 USP18_10138;UGT2B10_33303,UGT2B1_33224;TTR_10102;TF_10003;SULT1E1_32446;SLC27A2_9860;SIRT3_9828;SCD1_9787;RRS1_9755;RGN_9699;PSMB3_9589;PPCS_9540;PAX8_9432;PARP1_9425;NQO1_33055;MPC2_33219;LPL_32544;IARS2_8858;HSPD1_8849;HSD17B11_8832;HDC_8788;HADHB_8777;HADH_8776;HACL1_8775;GSTM7_8761;GSTM3_8760;GPX4_32827;GINS1_8707;FMO1_32787;EXOSC5_32543;ETFDH_8575;ERBB3_8571;EPHX2_33282;EPHX1_8567;EIF4EBP1_8550;EHHADH_8534;ECI2_8521;ECI1_8520;DHDDS_8467;CYP3A2_32374;CYP2J4_32580;CYP2A1_32717;CYP17A1_32365;CROT_8384;CHPT1_33298;CD36_8243;ANXA7_8051;AMPD1_32743;AMACR_8038;ALDH3A2_8024;AGMO_33265;ACOX1_7973;ACOT2_7969;ACOT12_32718;ACOT1_7968;ACADM_7957;ACADL_32776;ACAA2_7955;ABHD1_7949;ABCG2_32656;AASS_7936 38.85554 33.3125 26.330737164965345 27.33309901639344 25.7336 16.7772282203978 63.268626721311485 45.3228 61.87474771708971 108.883;47.47345;46.6406;45.1539;50.1846;7.62189;2.38018;105.46;60.39;77.4407;23.7888;20.3353;56.8931;26.9741;87.2765;46.8463;74.2041;24.7304;42.2579;22.4334;24.5745;31.8029;33.3125;17.6275;42.3152;73.0961;45.9204;58.9165;65.2792;41.9329;18.1231;60.9984;38.7293;12.4747;83.9001;8.62809;10.6467;11.9473;47.9438;12.8505;17.8395;55.3937;49.6922;7.4229;16.0559;48.1296;104.64;60.9045;2.03774;43.1079;31.5332;23.1906;8.54905;30.3423;31.2018;11.7137;33.4878;26.5872;17.2895;5.21654;27.4644 73.1414;34.82915;28.5876;28.132;36.5009;5.49916;0.56209;63.7532;43.109;58.7732;19.2724;16.7643;45.1162;21.799;60.6992;35.8494;49.8682;19.8021;23.9469;18.1233;21.0619;25.5756;25.7336;11.195;31.4035;51.4219;34.2198;44.7208;39.7882;31.7336;14.869;41.6036;29.2097;7.00435;42.4185;7.31865;8.92359;7.15307;36.5688;7.33176;14.6501;38.7444;35.6654;5.75707;10.6021;37.5433;43.9254;50.0633;1.165;31.8774;24.5474;16.2815;7.19676;24.0157;26.858;8.36151;26.6039;21.3695;14.2242;2.73368;21.7498 138.144;76.47475;63.7146;61.5341;80.9788;13.3925;8.82917;422.699;104.942;89.8047;30.901;25.6711;81.5688;35.2797;197.117;69.127;155.425;32.7087;102.383;29.2247;29.28;42.1484;46.9856;37.6534;64.5991;140.853;70.4292;91.837;82.9415;62.1373;23.0103;113.972;57.2113;23.684;107.32;10.3909;13.0581;19.001;71.3742;24.0283;22.6149;96.8569;81.6409;10.316;29.905;69.1421;108.689;82.6625;3.73641;66.3058;43.8459;33.4539;10.4125;41.1025;37.2719;18.9642;45.3228;35.0407;21.8526;11.386;37.0295 37 79426;246273;29573;29500;501907;293656;192280;83516;29441;303612;24651;25513;294103;24552;24516;54404;50693;306251;29540;25675;24957;294515;314322;25661;84493;24890;24330;116663;140942;25428;497840;81718;114851;54232;25698;25377;25303 ZFP36_10204;TRIB3_10079;SLC37A4_9871;SLC10A2_9833;RGD1559459_9690;RGD1307603_9684;PPP1R3B_9545;PPARGC1A_33189;POR_9531;POLG2_9521;PKLR_9489;PIK3R1_32562;PAPSS2_33237;ME1_9215;JUN_8938;ITIH4_32725;ITIH3_32422;ITIH1_33132;HSD17B7_8834;HMGCR_8810;GLUL_32832;FOXO3_8662;FOS_8657;FN1_8655;FMO3_8654;ESR1_33192;EGR1_8533;DUSP6_8506;DDIT4_8450;CYP7A1_8430;CPS1_32421;CDO1_8275;CDKN1A_8271;CAR3_8196;ASS1_33159;AMBP_33085;ABCC2_32541 35.13722932432437 27.1247 28.860213375628838 23.06916683783788 21.5108 18.969214118154287 61.57804378378383 45.5891 51.98393436865589 0.348134;108.064;39.7166;56.585;2.52378E-13;34.7372;36.1411;42.4094;12.4414;63.7758;23.0963;18.7324;34.4443;80.7944;16.4324;57.1163;27.1247;98.1741;0.977494;1.63089;26.4669;13.1992;1.28141E-12;59.5777;62.8595;23.3972;0.750017;62.3934;87.5421;5.72128;31.9826;22.9638;6.24967;53.9626;26.8037;17.2343;46.2316 0.118102;83.8836;22.6911;35.2796;2.52378E-13;26.1766;27.0588;26.2988;8.48981;40.9553;17.4625;11.6701;25.719;59.856;10.5224;39.6402;21.5108;42.9071;0.322682;0.663137;21.0456;5.6804;1.28141E-12;31.0499;42.5185;18.3088;0.186019;39.0875;53.2453;0.985273;24.4836;18.5144;2.44025;28.5034;20.9825;14.1233;31.1788 1.15962;143.428;60.0334;116.8;2.52379E-13;50.9085;53.6244;81.7305;79.2355;132.567;32.9443;41.5978;51.1014;94.0621;39.929;101.869;36.4819;104.278;5.49472;7.6286;35.4303;32.7581;1.28142E-12;105.243;120.21;31.9156;4.70178;133.304;245.492;22.3625;45.5891;30.0179;19.0606;77.0288;36.7081;21.9073;81.7848 0 Exp 2,39(0.4);Exp 3,4(0.05);Exp 4,6(0.07);Hill,10(0.11);Linear,22(0.23);Poly 2,15(0.16);Power,3(0.04) 2.2892144723498515 616.1479254961014 1.5074360370635986 344.14306640625 34.51680897334162 1.87713623046875 32.061216256287054 42.84215976412115 22.2262120257232 29.22028211713397 51.13372874675833 74.12696206956821 UP 0.6224489795918368 0.37755102040816324 0.0 GO:0051240 5 positive regulation of multicellular organismal process 484 516 45 45 33 39 28 28 134 488 1897 0.19256 0.85949 0.36422 5.43 24825;246074;83516;29441;85253;25513;81819;25591;24539;58954;24516;63868;24471;25675;113965;289388;294515;314322;25661;361969;29496;24330;65210;113936;25695;29184;25373;25287 tf;scd;ppargc1a;por;plg;pik3r1;pax8;parp1;lpl;klf6;jun;hspd1;hspb1;hmgcr;hadh;g0s2;foxo3;fos;fn1;fga;erbb3;egr1;cyp2j4;cpb2;cebpd;cd36;ahsg;acadl TF_10003;SCD1_9787;PPARGC1A_33189;POR_9531;PLG_9501;PIK3R1_32562;PAX8_9432;PARP1_9425;LPL_32544;KLF6_8969;JUN_8938;HSPD1_8849;HSPB1_8847;HMGCR_8810;HADH_8776;G0S2_32729;FOXO3_8662;FOS_8657;FN1_8655;FGA_8632;ERBB3_8571;EGR1_8533;CYP2J4_32580;CPB2_8369;CEBPD_8283;CD36_8243;AHSG_8003;ACADL_32776 35.79349796428576 30.9464 1.28141E-12 27.574603036133514 40.97110995012934 26.5593575854171 24.239253578571468 23.237949999999998 1.28141E-12 18.048388067253853 27.80939260004916 17.34515763990391 72.01732035714289 46.26685 1.28142E-12 80.56111581764695 77.89115970535372 71.3353304844871 24.5 72.4949 45.1539;105.46;42.4094;12.4414;70.7857;18.7324;56.8931;26.9741;74.2041;18.9476;16.4324;42.2579;89.1011;1.63089;33.3125;46.3784;13.1992;1.28141E-12;59.5777;28.5803;60.9984;0.750017;17.8395;25.8316;0.306936;48.1296;12.402;33.4878 28.132;63.7532;26.2988;8.48981;46.2356;11.6701;45.1162;21.799;49.8682;11.6941;10.5224;23.9469;60.3265;0.663137;25.7336;33.7914;5.6804;1.28141E-12;31.0499;22.529;41.6036;0.186019;14.6501;20.4374;0.0732342;37.5433;10.3013;26.6039 61.5341;422.699;81.7305;79.2355;150.579;41.5978;81.5688;35.2797;155.425;45.5481;39.929;102.383;106.138;7.6286;46.9856;73.6529;32.7581;1.28142E-12;105.243;38.8511;113.972;4.70178;22.6149;34.8042;1.73689;69.1421;15.4235;45.3228 12 16 12 24825;246074;81819;25591;24539;63868;113965;289388;29496;65210;29184;25287 TF_10003;SCD1_9787;PAX8_9432;PARP1_9425;LPL_32544;HSPD1_8849;HADH_8776;G0S2_32729;ERBB3_8571;CYP2J4_32580;CD36_8243;ACADL_32776 49.257441666666665 45.766149999999996 23.43107375207928 34.37845 30.9617 13.853565513122021 102.54832499999999 71.39750000000001 107.35351591977133 45.1539;105.46;56.8931;26.9741;74.2041;42.2579;33.3125;46.3784;60.9984;17.8395;48.1296;33.4878 28.132;63.7532;45.1162;21.799;49.8682;23.9469;25.7336;33.7914;41.6036;14.6501;37.5433;26.6039 61.5341;422.699;81.5688;35.2797;155.425;102.383;46.9856;73.6529;113.972;22.6149;69.1421;45.3228 16 83516;29441;85253;25513;58954;24516;24471;25675;294515;314322;25661;361969;24330;113936;25695;25373 PPARGC1A_33189;POR_9531;PLG_9501;PIK3R1_32562;KLF6_8969;JUN_8938;HSPB1_8847;HMGCR_8810;FOXO3_8662;FOS_8657;FN1_8655;FGA_8632;EGR1_8533;CPB2_8369;CEBPD_8283;AHSG_8003 25.69554018750008 17.5824 26.68793111856816 16.63485626250008 11.09625 17.368732408360856 49.11906687500009 39.39005 43.88240573010919 42.4094;12.4414;70.7857;18.7324;18.9476;16.4324;89.1011;1.63089;13.1992;1.28141E-12;59.5777;28.5803;0.750017;25.8316;0.306936;12.402 26.2988;8.48981;46.2356;11.6701;11.6941;10.5224;60.3265;0.663137;5.6804;1.28141E-12;31.0499;22.529;0.186019;20.4374;0.0732342;10.3013 81.7305;79.2355;150.579;41.5978;45.5481;39.929;106.138;7.6286;32.7581;1.28142E-12;105.243;38.8511;4.70178;34.8042;1.73689;15.4235 0 Exp 2,9(0.33);Exp 3,1(0.04);Exp 4,2(0.08);Hill,3(0.11);Linear,6(0.22);Poly 2,6(0.22);Power,1(0.04) 1.9840576129551286 57.79649305343628 1.5254690647125244 4.21828556060791 0.6814703144026006 1.8608487248420715 25.579722065394733 46.00727386317678 17.554037083755958 30.924470073386985 42.1770654657917 101.85757524849409 CONFLICT 0.42857142857142855 0.5714285714285714 0.0 GO:0045944 9 positive regulation of transcription by RNA polymerase II 241 260 20 20 16 17 14 14 148 246 2139 0.3002 0.78933 0.59182 5.38 83516;25513;81819;25591;25493;58954;24516;494344;290556;294515;314322;24890;24330;25695 ppargc1a;pik3r1;pax8;parp1;nfkbia;klf6;jun;ier2;gnl3;foxo3;fos;esr1;egr1;cebpd PPARGC1A_33189;PIK3R1_32562;PAX8_9432;PARP1_9425;NFKBIA_9307;KLF6_8969;JUN_8938;IER2_32643;GNL3_8735;FOXO3_8662;FOS_8657;ESR1_33192;EGR1_8533;CEBPD_8283 25.419971714285804 18.84 1.28141E-12 25.671452756065772 27.48398205980862 22.93075202246597 17.098703942857234 11.6821 1.28141E-12 17.41038119907084 19.40648308275972 16.759459314186923 52.00390428571438 37.60435 1.28142E-12 61.60899872539363 49.175938550448244 43.79911436492712 12.0 56.8931 42.4094;18.7324;56.8931;26.9741;0.520151;18.9476;16.4324;49.6814;87.6357;13.1992;1.28141E-12;23.3972;0.750017;0.306936 26.2988;11.6701;45.1162;21.799;0.160202;11.6941;10.5224;33.4626;54.41;5.6804;1.28141E-12;18.3088;0.186019;0.0732342 81.7305;41.5978;81.5688;35.2797;2.88499;45.5481;39.929;89.4404;238.963;32.7581;1.28142E-12;31.9156;4.70178;1.73689 3 11 3 81819;25591;290556 PAX8_9432;PARP1_9425;GNL3_8735 57.167633333333335 56.8931 30.331731817575683 40.44173333333333 45.1162 16.80051514726062 118.60383333333334 81.5688 106.77273502736234 56.8931;26.9741;87.6357 45.1162;21.799;54.41 81.5688;35.2797;238.963 11 83516;25513;25493;58954;24516;494344;294515;314322;24890;24330;25695 PPARGC1A_33189;PIK3R1_32562;NFKBIA_9307;KLF6_8969;JUN_8938;IER2_32643;FOXO3_8662;FOS_8657;ESR1_33192;EGR1_8533;CEBPD_8283 16.76151854545466 16.4324 16.96725798974413 10.732423200000115 10.5224 11.38221128864821 33.84028727272739 32.7581 30.99535620131301 42.4094;18.7324;0.520151;18.9476;16.4324;49.6814;13.1992;1.28141E-12;23.3972;0.750017;0.306936 26.2988;11.6701;0.160202;11.6941;10.5224;33.4626;5.6804;1.28141E-12;18.3088;0.186019;0.0732342 81.7305;41.5978;2.88499;45.5481;39.929;89.4404;32.7581;1.28142E-12;31.9156;4.70178;1.73689 0 Exp 2,6(0.43);Exp 4,2(0.15);Hill,3(0.22);Poly 2,3(0.22) 1.9234752535597632 27.91453242301941 1.5740432739257812 4.21828556060791 0.6769045908993814 1.7867289185523987 11.97244239753256 38.86750103103905 7.978588544049737 26.21881934166474 19.73113716154822 84.27667140988055 DOWN 0.21428571428571427 0.7857142857142857 0.0 GO:0045892 8 negative regulation of transcription, DNA-templated 221 232 16 16 12 14 11 11 151 221 2164 0.18025 0.8888 0.32604 4.74 79426;24522;246273;24516;25112;294515;24890;24330;25695;29184;79431 zfp36;zfp354a;trib3;jun;gadd45a;foxo3;esr1;egr1;cebpd;cd36;bhlhe40 ZFP36_10204;ZFP354A_10203;TRIB3_10079;JUN_8938;GADD45A_8678;FOXO3_8662;ESR1_33192;EGR1_8533;CEBPD_8283;CD36_8243;BHLHE40_8141 33.83543763636363 16.4324 0.306936 40.40837904664512 36.875769049455755 43.74435815883489 25.857918654545458 10.5224 0.0732342 33.242219840385694 29.55384341719029 36.85402505978059 50.344241818181814 32.7581 1.15962 51.717861867334165 50.19397040354581 52.63458661084956 0.348134;0.834827;108.064;16.4324;102.919;13.1992;23.3972;0.750017;0.306936;48.1296;57.8085 0.118102;0.27095;83.8836;10.5224;89.5012;5.6804;18.3088;0.186019;0.0732342;37.5433;38.3491 1.15962;2.99857;143.428;39.929;115.437;32.7581;31.9156;4.70178;1.73689;69.1421;110.58 1 10 1 29184 CD36_8243 48.1296 48.1296 37.5433 37.5433 69.1421 69.1421 48.1296 37.5433 69.1421 10 79426;24522;246273;24516;25112;294515;24890;24330;25695;79431 ZFP36_10204;ZFP354A_10203;TRIB3_10079;JUN_8938;GADD45A_8678;FOXO3_8662;ESR1_33192;EGR1_8533;CEBPD_8283;BHLHE40_8141 32.4060214 14.8158 42.300007336915165 24.689380519999997 8.1014 34.801418949771694 48.464456 32.33685 54.117851790575685 0.348134;0.834827;108.064;16.4324;102.919;13.1992;23.3972;0.750017;0.306936;57.8085 0.118102;0.27095;83.8836;10.5224;89.5012;5.6804;18.3088;0.186019;0.0732342;38.3491 1.15962;2.99857;143.428;39.929;115.437;32.7581;31.9156;4.70178;1.73689;110.58 0 Exp 2,3(0.28);Exp 4,1(0.1);Hill,4(0.37);Poly 2,3(0.28) 2.2681810014488564 26.6647869348526 1.627708911895752 4.591650485992432 1.0334114842396902 1.9785058498382568 9.95561162718231 57.715263645544965 6.21302210892982 45.50281520016109 19.78093856038016 80.90754507598348 DOWN 0.09090909090909091 0.9090909090909091 0.0 GO:0071276 7 cellular response to cadmium ion 18 20 4 4 4 3 3 3 159 17 2368 0.96571 0.13018 0.13018 15.0 24567;24516;314322 mt1;jun;fos MT1A_9255;JUN_8938;FOS_8657 9.787966666667094 12.9315 1.28141E-12 8.655477676207179 10.591196047088367 8.673881148498761 6.477576666667093 8.91033 1.28141E-12 5.66735758759098 6.944867448575355 5.629933164432932 21.130866666667092 23.4636 1.28142E-12 20.06645194979188 23.677304114002865 20.671892562345324 0.0 1.28141E-12 1.0 12.9315 12.9315;16.4324;1.28141E-12 8.91033;10.5224;1.28141E-12 23.4636;39.929;1.28142E-12 0 3 0 3 24567;24516;314322 MT1A_9255;JUN_8938;FOS_8657 9.787966666667094 12.9315 8.655477676207179 6.477576666667093 8.91033 5.66735758759098 21.130866666667092 23.4636 20.06645194979188 12.9315;16.4324;1.28141E-12 8.91033;10.5224;1.28141E-12 23.4636;39.929;1.28142E-12 0 Hill,1(0.34);Poly 2,2(0.67) 2.0433079466150383 6.148557901382446 1.8966681957244873 2.273383855819702 0.19814352062895038 1.9785058498382568 -0.006628371326005578 19.582561704660193 0.06435782623963604 12.890795507094552 -1.5764613457232493 43.83819467905744 DOWN 0.0 1.0 0.0 GO:0010656 9 negative regulation of muscle cell apoptotic process 23 27 6 6 5 5 4 4 158 23 2362 0.97479 0.088224 0.088224 14.81 25513;81819;25675;50559 pik3r1;pax8;hmgcr;acot1 PIK3R1_32562;PAX8_9432;HMGCR_8810;ACOT1_7968 27.1145475 24.9671 1.63089 23.260445813175885 37.46640565635394 19.18504071303763 21.07685925 19.26405 0.663137 19.2917829464043 30.10698558627602 15.653596897952234 42.016774999999996 39.43485 7.6286 30.38419896507339 52.99504076639175 26.735769404854004 0.5 10.181645 1.5 24.9671 18.7324;56.8931;1.63089;31.2018 11.6701;45.1162;0.663137;26.858 41.5978;81.5688;7.6286;37.2719 2 2 2 81819;50559 PAX8_9432;ACOT1_7968 44.04745 44.04745 18.16649244749794 35.9871 35.9871 12.910497032260237 59.42035 59.42035 31.322638375542375 56.8931;31.2018 45.1162;26.858 81.5688;37.2719 2 25513;25675 PIK3R1_32562;HMGCR_8810 10.181645 10.181645 12.092593689529552 6.1666185 6.1666185 7.783098177569424 24.6132 24.6132 24.01985167148207 18.7324;1.63089 11.6701;0.663137 41.5978;7.6286 0 Exp 2,2(0.5);Exp 4,1(0.25);Poly 2,1(0.25) 6.618836864463144 349.47061455249786 1.6735800504684448 344.14306640625 171.18363467739445 1.8269840478897095 4.319310603087626 49.90978439691236 2.170911962523789 39.98280653747621 12.240260014228081 71.7932899857719 CONFLICT 0.5 0.5 0.0 GO:0009750 8 response to fructose 10 10 3 3 2 3 2 2 160 8 2377 0.97825 0.12934 0.12934 20.0 83516;25513 ppargc1a;pik3r1 PPARGC1A_33189;PIK3R1_32562 30.570899999999998 30.570899999999998 18.7324 16.74216725815389 33.63174336525308 16.172898326730802 18.98445 18.98445 11.6701 10.344052969943654 20.875574692202463 9.992333393261273 61.66415000000001 61.66415000000001 41.5978 28.378104317325356 66.85230341997266 27.41318903058619 0.0 18.7324 0.0 18.7324 42.4094;18.7324 26.2988;11.6701 81.7305;41.5978 0 2 0 2 83516;25513 PPARGC1A_33189;PIK3R1_32562 30.570899999999998 30.570899999999998 16.74216725815389 18.98445 18.98445 10.344052969943654 61.66415000000001 61.66415000000001 28.378104317325356 42.4094;18.7324 26.2988;11.6701 81.7305;41.5978 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.7150868540604944 3.4312031269073486 1.6735800504684448 1.7576230764389038 0.059427393575148674 1.7156015634536743 7.3674400000000055 53.77435999999999 4.648323999999999 33.320576 22.33410400000001 100.994196 DOWN 0.0 1.0 0.0 GO:0051503 9 adenine nucleotide transport 5 5 1 1 1 1 1 1 161 4 2381 0.9646 0.28025 0.28025 20.0 361074 slc25a30 SLC25A30_9856 53.013 53.013 53.013 53.013 37.4804 37.4804 37.4804 37.4804 90.2594 90.2594 90.2594 90.2594 0.0 53.013 0.0 53.013 53.013 37.4804 90.2594 1 0 1 361074 SLC25A30_9856 53.013 53.013 37.4804 37.4804 90.2594 90.2594 53.013 37.4804 90.2594 0 0 Linear,1(1) 3.6488525867462154 3.648852586746216 3.648852586746216 3.648852586746216 0.0 3.648852586746216 53.013 53.013 37.4804 37.4804 90.2594 90.2594 UP 1.0 0.0 0.0 GO:0051051 5 negative regulation of transport 140 146 18 18 14 14 10 10 152 136 2249 0.67746 0.45233 0.72818 6.85 25591;25675;113965;81869;25661;24890;29496;29184;170465;312382 parp1;hmgcr;hadh;gstm7;fn1;esr1;erbb3;cd36;acaa2;abcg2 PARP1_9425;HMGCR_8810;HADH_8776;GSTM7_8761;FN1_8655;ESR1_33192;ERBB3_8571;CD36_8243;ACAA2_7955;ABCG2_32656 32.813933000000006 30.1433 1.63089 20.361468753693714 36.77812574818516 19.35790507615414 23.220801700000003 23.7663 0.663137 13.481566463862757 25.56065744254156 12.240660491351003 52.119240000000005 41.13265 7.6286 36.119899590275104 58.34100615252517 35.76814891744291 6.5 45.2224 26.9741;1.63089;33.3125;42.3152;59.5777;23.3972;60.9984;48.1296;26.5872;5.21654 21.799;0.663137;25.7336;31.4035;31.0499;18.3088;41.6036;37.5433;21.3695;2.73368 35.2797;7.6286;46.9856;64.5991;105.243;31.9156;113.972;69.1421;35.0407;11.386 7 3 7 25591;113965;81869;29496;29184;170465;312382 PARP1_9425;HADH_8776;GSTM7_8761;ERBB3_8571;CD36_8243;ACAA2_7955;ABCG2_32656 34.790505714285715 33.3125 17.919265959860866 26.026597142857145 25.7336 12.821827189057615 53.77217142857143 46.9856 32.94682849722737 26.9741;33.3125;42.3152;60.9984;48.1296;26.5872;5.21654 21.799;25.7336;31.4035;41.6036;37.5433;21.3695;2.73368 35.2797;46.9856;64.5991;113.972;69.1421;35.0407;11.386 3 25675;25661;24890 HMGCR_8810;FN1_8655;ESR1_33192 28.20193 23.3972 29.270672525135115 16.67394566666667 18.3088 15.259207152501611 48.26239999999999 31.9156 50.81885648575734 1.63089;59.5777;23.3972 0.663137;31.0499;18.3088 7.6286;105.243;31.9156 0 Exp 2,4(0.4);Exp 4,2(0.2);Linear,3(0.3);Power,1(0.1) 1.982176534714584 20.253326892852783 1.5074360370635986 2.8333094120025635 0.4580807909196607 1.8552199006080627 20.193763917467656 45.43410208253233 14.864840235261312 31.576763164738686 29.73189429387701 74.50658570612298 UP 0.7 0.3 0.0 GO:0035634 6 response to stilbenoid 13 15 6 6 4 6 4 4 158 11 2374 0.99826 0.012381 0.012381 26.67 312688;83516;246186;29184 usp18;ppargc1a;fgl1;cd36 USP18_10138;PPARGC1A_33189;FGL1_8640;CD36_8243 53.724425 45.2695 15.4757 39.43249598020859 42.896889700757974 33.06804370672783 36.799325 31.92105 10.2138 26.69800915741035 29.983085282178397 22.883831830169175 79.8568 75.4363 30.4106 44.574431856764406 66.39592035061251 39.214248594656674 0.0 15.4757 0.5 28.942549999999997 108.883;42.4094;15.4757;48.1296 73.1414;26.2988;10.2138;37.5433 138.144;81.7305;30.4106;69.1421 2 2 2 312688;29184 USP18_10138;CD36_8243 78.5063 78.5063 42.959141120138796 55.34235 55.34235 25.17165790735685 103.64305 103.64305 48.791711404756036 108.883;48.1296 73.1414;37.5433 138.144;69.1421 2 83516;246186 PPARGC1A_33189;FGL1_8640 28.942549999999997 28.942549999999997 19.04500191244412 18.2563 18.2563 11.373812575385625 56.070550000000004 56.070550000000004 36.28864929981551 42.4094;15.4757 26.2988;10.2138 81.7305;30.4106 0 Exp 2,2(0.5);Poly 2,1(0.25);Power,1(0.25) 1.8649353685446917 7.644594311714172 1.511321783065796 2.6703107357025146 0.5170804019854383 1.731480896472931 15.08057893939558 92.36827106060441 10.635276025737856 62.96337397426214 36.17385678037089 123.53974321962912 CONFLICT 0.5 0.5 0.0 GO:0051052 6 regulation of DNA metabolic process 84 88 7 7 7 6 6 6 156 82 2303 0.67426 0.49263 0.82303 6.82 25106;83516;303612;25591;290556;114851 rgn;ppargc1a;polg2;parp1;gnl3;cdkn1a RGN_9699;PPARGC1A_33189;POLG2_9521;PARP1_9425;GNL3_8735;CDKN1A_8271 50.74756166666666 53.0926 6.24967 31.16972300238192 38.558396966102215 29.568074940474396 34.11275833333333 33.62705 2.44025 21.367124992296386 26.608891474845574 21.498672083980413 99.56758333333333 85.7676 19.0606 79.43277085655308 66.48745200528596 55.70268050320325 3.5 70.60825 77.4407;42.4094;63.7758;26.9741;87.6357;6.24967 58.7732;26.2988;40.9553;21.799;54.41;2.44025 89.8047;81.7305;132.567;35.2797;238.963;19.0606 3 3 3 25106;25591;290556 RGN_9699;PARP1_9425;GNL3_8735 64.01683333333334 77.4407 32.48241948890714 44.99406666666667 54.41 20.205635768600136 121.34913333333333 89.8047 105.4419751828622 77.4407;26.9741;87.6357 58.7732;21.799;54.41 89.8047;35.2797;238.963 3 83516;303612;114851 PPARGC1A_33189;POLG2_9521;CDKN1A_8271 37.478289999999994 42.4094 29.07835608435078 23.23145 26.2988 19.43987515758525 77.78603333333334 81.7305 56.855912825345925 42.4094;63.7758;6.24967 26.2988;40.9553;2.44025 81.7305;132.567;19.0606 0 Exp 2,4(0.67);Exp 4,1(0.17);Poly 2,1(0.17) 1.6532554000422466 9.941266298294067 1.522104263305664 1.8086696863174438 0.1201483726469593 1.6512072682380676 25.806588851955716 75.68853448137762 17.015497522877276 51.21001914378939 36.00812923170204 163.12703743496462 CONFLICT 0.5 0.5 0.0 GO:1903522 6 regulation of blood circulation 63 68 4 4 2 4 2 2 160 66 2319 0.18106 0.93803 0.3187 2.94 25513;361969 pik3r1;fga PIK3R1_32562;FGA_8632 23.65635 23.65635 18.7324 6.9635168704469965 26.003220189909072 6.121680147511153 17.09955 17.09955 11.6701 7.678401826226598 19.687353359620182 6.750140898446265 40.224450000000004 40.224450000000004 38.8511 1.9422101958850324 39.569879142190395 1.7074116168083544 18.7324;28.5803 11.6701;22.529 41.5978;38.8511 0 2 0 2 25513;361969 PIK3R1_32562;FGA_8632 23.65635 23.65635 6.9635168704469965 17.09955 17.09955 7.678401826226598 40.224450000000004 40.224450000000004 1.9422101958850324 18.7324;28.5803 11.6701;22.529 41.5978;38.8511 0 Linear,1(0.5);Poly 2,1(0.5) 1.6063891688805763 3.215475916862488 1.541895866394043 1.6735800504684448 0.09311477953402712 1.607737958431244 14.005407999999997 33.307292000000004 6.457828000000001 27.741272000000002 37.53268400000001 42.916216 DOWN 0.0 1.0 0.0 GO:0019221 6 cytokine-mediated signaling pathway 83 85 5 5 5 4 4 4 158 81 2304 0.36113 0.80149 0.65549 4.71 25493;58954;294515;24330 nfkbia;klf6;foxo3;egr1 NFKBIA_9307;KLF6_8969;FOXO3_8662;EGR1_8533 8.354242 6.9746084999999995 0.520151 9.217557004341119 7.323367395774869 9.451792212632817 4.43018025 2.9332095 0.160202 5.494639767664626 4.028162550748363 5.766876010194064 21.473242499999998 18.72994 2.88499 21.08515953487409 19.340624089491737 21.358809255217402 0.520151;18.9476;13.1992;0.750017 0.160202;11.6941;5.6804;0.186019 2.88499;45.5481;32.7581;4.70178 0 4 0 4 25493;58954;294515;24330 NFKBIA_9307;KLF6_8969;FOXO3_8662;EGR1_8533 8.354242 6.9746084999999995 9.217557004341119 4.43018025 2.9332095 5.494639767664626 21.473242499999998 18.72994 21.08515953487409 0.520151;18.9476;13.1992;0.750017 0.160202;11.6941;5.6804;0.186019 2.88499;45.5481;32.7581;4.70178 0 Exp 4,2(0.5);Hill,1(0.25);Poly 2,1(0.25) 2.224456001765648 9.635276317596436 1.5740432739257812 4.21828556060791 1.2186020813314786 1.921473741531372 -0.6789638642542943 17.3874478642543 -0.9545667223113341 9.814927222311335 0.8097861558233959 42.1366988441766 DOWN 0.0 1.0 0.0 GO:0033539 8 fatty acid beta-oxidation using acyl-CoA dehydrogenase 7 7 5 5 3 5 3 3 159 4 2381 0.99953 0.0073103 0.0073103 42.86 295143;24158;25287 etfdh;acadm;acadl ETFDH_8575;ACADM_7957;ACADL_32776 21.1082 18.1231 11.7137 11.189770963250316 19.832743492518958 10.716554066296979 16.61147 14.869 8.36151 9.245179798343562 15.559950595408894 8.907787158675688 29.099100000000004 23.0103 18.9642 14.195036546976551 27.499420403771264 13.454354197494238 0.0 11.7137 0.0 11.7137 18.1231;11.7137;33.4878 14.869;8.36151;26.6039 23.0103;18.9642;45.3228 3 0 3 295143;24158;25287 ETFDH_8575;ACADM_7957;ACADL_32776 21.1082 18.1231 11.189770963250316 16.61147 14.869 9.245179798343562 29.099100000000004 23.0103 14.195036546976551 18.1231;11.7137;33.4878 14.869;8.36151;26.6039 23.0103;18.9642;45.3228 0 0 Exp 2,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 1.7818579150711515 5.350896120071411 1.693061113357544 1.8872262239456177 0.09773549234836842 1.7706087827682495 8.44578213550645 33.77061786449355 6.14956419125091 27.07337580874909 13.035903983755166 45.16229601624484 UP 1.0 0.0 0.0 GO:0051179 2 localization 693 737 59 57 43 53 38 38 124 699 1686 0.064841 0.9556 0.12777 5.16 257644;79426;24856;171139;24825;170698;29573;25351;65192;361074;29482;29500;297784;308821;298199;25513;81525;25493;100359982;81678;192235;63868;24471;85255;24384;24360;304929;24890;25428;83842;170945;81718;114851;29184;65054;312382;140668;25303 zwint;zfp36;ttr;timm9;tf;slco1a2;slc37a4;slc2a2;slc27a2;slc25a30;slc1a2;slc10a2;rrs1;rab30;plin2;pik3r1;nfkbib;nfkbia;mpc2;itpr2;hyou1;hspd1;hspb1;hacl1;gc;fabp1;f5;esr1;cyp7a1;crot;chrna2;cdo1;cdkn1a;cd36;aqp9;abcg2;abcc3;abcc2 ZWINT_10214;ZFP36_10204;TTR_10102;TIMM9_10020;TF_10003;SLCO1A2_9886;SLC37A4_9871;SLC2A2_9863;SLC27A2_9860;SLC25A30_9856;SLC1A2_33059;SLC10A2_9833;RRS1_9755;RAB30_9639;PLIN2_9502;PIK3R1_32562;NFKBIB_9308;NFKBIA_9307;MPC2_33219;ITPR2_8931;HYOU1_8857;HSPD1_8849;HSPB1_8847;HACL1_8775;GC_32893;FABP1_33091;F5_33079;ESR1_33192;CYP7A1_8430;CROT_8384;CHRNA2_32401;CDO1_8275;CDKN1A_8271;CD36_8243;AQP9_32709;ABCG2_32656;ABCC3_7941;ABCC2_32541 171139(0.04986) 33.78879118421054 32.82945 0.348134 22.719029276517617 34.81000096984191 20.538605538746058 24.030138078947374 24.095399999999998 0.118102 16.911824090888768 24.58555927329734 14.899587410267518 52.79560552631578 45.62765 1.15962 32.24585197783622 54.093696955890636 30.080060348406363 35.5 74.74555000000001 52.0003;0.348134;46.6406;38.5191;45.1539;104.197;39.7166;29.7555;7.62189;53.013;13.3235;56.585;60.39;26.4203;25.6517;18.7324;30.5572;0.520151;46.8463;31.8111;40.1982;42.2579;89.1011;17.6275;42.356;33.8478;10.6089;23.3972;5.72128;7.4229;49.3913;22.9638;6.24967;48.1296;27.7316;5.21654;37.7175;46.2316 38.9015;0.118102;28.5876;29.55;28.132;80.3101;22.6911;23.3399;5.49916;37.4804;9.10952;35.2796;43.109;21.0125;20.9252;11.6701;24.2439;0.160202;35.8494;24.7342;29.3844;23.9469;60.3265;11.195;26.3722;26.4736;2.59129;18.3088;0.985273;5.75707;41.8524;18.5144;2.44025;37.5433;21.9372;2.73368;30.9007;31.1788 80.8613;1.15962;63.7146;55.4685;61.5341;128.412;60.0334;40.808;13.3925;90.2594;24.6773;116.8;104.942;35.3561;33.0375;41.5978;41.2611;2.88499;69.127;44.3296;62.3571;102.383;106.138;37.6534;78.7583;46.9257;37.5078;31.9156;22.3625;10.316;62.472;30.0179;19.0606;69.1421;37.4625;11.386;48.9329;81.7848 19 19 19 257644;24856;171139;24825;65192;361074;297784;308821;298199;81525;100359982;63868;85255;24360;83842;170945;29184;312382;140668 ZWINT_10214;TTR_10102;TIMM9_10020;TF_10003;SLC27A2_9860;SLC25A30_9856;RRS1_9755;RAB30_9639;PLIN2_9502;NFKBIB_9308;MPC2_33219;HSPD1_8849;HACL1_8775;FABP1_33091;CROT_8384;CHRNA2_32401;CD36_8243;ABCG2_32656;ABCC3_7941 35.49607 38.5191 16.6087667902637 25.983858421052627 28.132 12.403183279375535 54.640273684210534 55.4685 28.198808765853162 52.0003;46.6406;38.5191;45.1539;7.62189;53.013;60.39;26.4203;25.6517;30.5572;46.8463;42.2579;17.6275;33.8478;7.4229;49.3913;48.1296;5.21654;37.7175 38.9015;28.5876;29.55;28.132;5.49916;37.4804;43.109;21.0125;20.9252;24.2439;35.8494;23.9469;11.195;26.4736;5.75707;41.8524;37.5433;2.73368;30.9007 80.8613;63.7146;55.4685;61.5341;13.3925;90.2594;104.942;35.3561;33.0375;41.2611;69.127;102.383;37.6534;46.9257;10.316;62.472;69.1421;11.386;48.9329 19 79426;170698;29573;25351;29482;29500;25513;25493;81678;192235;24471;24384;304929;24890;25428;81718;114851;65054;25303 ZFP36_10204;SLCO1A2_9886;SLC37A4_9871;SLC2A2_9863;SLC1A2_33059;SLC10A2_9833;PIK3R1_32562;NFKBIA_9307;ITPR2_8931;HYOU1_8857;HSPB1_8847;GC_32893;F5_33079;ESR1_33192;CYP7A1_8430;CDO1_8275;CDKN1A_8271;AQP9_32709;ABCC2_32541 32.08151236842105 27.7316 27.910199174539276 22.076417736842107 21.9372 20.64005585429991 50.95093736842106 40.808 36.537649360176694 0.348134;104.197;39.7166;29.7555;13.3235;56.585;18.7324;0.520151;31.8111;40.1982;89.1011;42.356;10.6089;23.3972;5.72128;22.9638;6.24967;27.7316;46.2316 0.118102;80.3101;22.6911;23.3399;9.10952;35.2796;11.6701;0.160202;24.7342;29.3844;60.3265;26.3722;2.59129;18.3088;0.985273;18.5144;2.44025;21.9372;31.1788 1.15962;128.412;60.0334;40.808;24.6773;116.8;41.5978;2.88499;44.3296;62.3571;106.138;78.7583;37.5078;31.9156;22.3625;30.0179;19.0606;37.4625;81.7848 0 Exp 2,14(0.37);Exp 3,2(0.06);Exp 4,3(0.08);Hill,4(0.11);Linear,6(0.16);Poly 2,9(0.24) 2.0288961084372805 81.58857548236847 1.5074360370635986 5.963563919067383 0.898124535051841 1.8567861318588257 26.56518528095227 41.01239708746878 18.652956208589988 29.40731994930476 42.54290837681884 63.04830267581269 CONFLICT 0.5 0.5 0.0 GO:1905205 7 positive regulation of connective tissue replacement 1 1 1 1 1 1 1 1 161 0 2385 1.0 0.063604 0.063604 100.0 58954 klf6 KLF6_8969 18.9476 18.9476 18.9476 18.9476 11.6941 11.6941 11.6941 11.694100000000002 45.5481 45.5481 45.5481 45.5481 0.0 18.9476 0.0 18.9476 18.9476 11.6941 45.5481 0 1 0 1 58954 KLF6_8969 18.9476 18.9476 11.6941 11.6941 45.5481 45.5481 18.9476 11.6941 45.5481 0 Poly 2,1(1) 1.5740432739257812 1.5740432739257812 1.5740432739257812 1.5740432739257812 0.0 1.5740432739257812 18.9476 18.9476 11.6941 11.6941 45.5481 45.5481 DOWN 0.0 1.0 0.0 GO:1903699 7 tarsal gland development 1 1 1 1 1 1 1 1 161 0 2385 1.0 0.063604 0.063604 100.0 246074 scd SCD1_9787 105.46 105.46 105.46 105.46 63.7532 63.7532 63.7532 63.7532 422.699 422.699 422.699 422.699 0.0 105.46 0.0 105.46 105.46 63.7532 422.699 1 0 1 246074 SCD1_9787 105.46 105.46 63.7532 63.7532 422.699 422.699 105.46 63.7532 422.699 0 0 Exp 2,1(1) 2.2368218898773193 2.2368218898773193 2.2368218898773193 2.2368218898773193 0.0 2.2368218898773193 105.46 105.46 63.7532 63.7532 422.699 422.699 UP 1.0 0.0 0.0 GO:0043281 8 regulation of cysteine-type endopeptidase activity involved in apoptotic process 84 87 6 6 5 4 3 3 159 84 2301 0.18389 0.92404 0.36906 3.45 29441;63868;24360 por;hspd1;fabp1 POR_9531;HSPD1_8849;FABP1_33091 29.5157 33.8478 12.4414 15.37306852485866 29.32812777433354 15.628332568563874 19.63677 23.9469 8.48981 9.73586622513375 19.367461072535654 9.784532232788877 76.1814 79.2355 46.9257 27.854509077167364 77.2583220537677 27.463371419073237 12.4414;42.2579;33.8478 8.48981;23.9469;26.4736 79.2355;102.383;46.9257 2 1 2 63868;24360 HSPD1_8849;FABP1_33091 38.05285 38.05285 5.946838740456993 25.210250000000002 25.210250000000002 1.786646704023996 74.65435 74.65435 39.214232896296714 42.2579;33.8478 23.9469;26.4736 102.383;46.9257 1 29441 POR_9531 12.4414 12.4414 8.48981 8.48981 79.2355 79.2355 12.4414 8.48981 79.2355 0 Exp 2,1(0.34);Exp 3,1(0.34);Poly 2,1(0.34) 2.030342731595342 6.109121203422546 1.8753424882888794 2.2518506050109863 0.19406915004110142 1.9819281101226807 12.11943530784849 46.91196469215151 8.619600227684696 30.6539397723153 44.66105570485898 107.70174429514101 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0006260 6 DNA replication 28 29 3 3 2 3 2 2 160 27 2358 0.72053 0.55973 0.70682 6.9 303612;499914 polg2;gins1 POLG2_9521;GINS1_8707 61.346149999999994 61.346149999999994 58.9165 3.4360439818198354 60.46283865060634 3.2009249233716304 42.838049999999996 42.838049999999996 40.9553 2.66261058455807 43.52253313257915 2.480415450570689 112.202 112.202 91.837 28.800459197728205 104.79820289737123 26.829722826115926 0.5 61.346149999999994 63.7758;58.9165 40.9553;44.7208 132.567;91.837 1 1 1 499914 GINS1_8707 58.9165 58.9165 44.7208 44.7208 91.837 91.837 58.9165 44.7208 91.837 1 303612 POLG2_9521 63.7758 63.7758 40.9553 40.9553 132.567 132.567 63.7758 40.9553 132.567 0 Exp 2,2(1) 1.5609779868569318 3.1220273971557617 1.5504547357559204 1.5715726613998413 0.014932628427409755 1.5610136985778809 56.584036 66.10826399999999 39.14786 46.52823999999999 72.28659999999999 152.1174 CONFLICT 0.5 0.5 0.0 GO:1903427 7 negative regulation of reactive oxygen species biosynthetic process 12 13 2 2 2 2 2 2 160 11 2374 0.95495 0.19842 0.19842 15.38 25106;63868 rgn;hspd1 RGN_9699;HSPD1_8849 59.8493 59.8493 42.2579 24.877996461130085 58.41986279809221 24.795727988740392 41.36005 41.36005 23.9469 24.625912893637068 39.94509698816463 24.544478030579437 96.09385 96.09385 89.8047 8.894201225798568 96.60489204204202 8.864789197016258 0.0 42.2579 0.5 59.8493 77.4407;42.2579 58.7732;23.9469 89.8047;102.383 2 0 2 25106;63868 RGN_9699;HSPD1_8849 59.8493 59.8493 24.877996461130085 41.36005 41.36005 24.625912893637068 96.09385 96.09385 8.894201225798568 77.4407;42.2579 58.7732;23.9469 89.8047;102.383 0 0 Exp 3,1(0.5);Poly 2,1(0.5) 1.9679754949507324 3.9717371463775635 1.7198865413665771 2.2518506050109863 0.3761553967505139 1.9858685731887817 25.370155999999994 94.328444 7.2302760000000035 75.489824 83.767116 108.420584 UP 1.0 0.0 0.0 GO:0043122 7 regulation of I-kappaB kinase/NF-kappaB signaling 56 62 4 4 3 4 3 3 159 59 2326 0.43621 0.76661 0.79558 4.84 24471;24890;29184 hspb1;esr1;cd36 HSPB1_8847;ESR1_33192;CD36_8243 53.542633333333335 48.1296 23.3972 33.184730166197426 61.88182119311054 28.28008695255699 38.726200000000006 37.5433 18.3088 21.033811295863615 44.65472985057603 16.90199337181315 69.06523333333332 69.1421 31.9156 37.111259703806006 80.10396876924831 28.865470539748742 89.1011;23.3972;48.1296 60.3265;18.3088;37.5433 106.138;31.9156;69.1421 1 2 1 29184 CD36_8243 48.1296 48.1296 37.5433 37.5433 69.1421 69.1421 48.1296 37.5433 69.1421 2 24471;24890 HSPB1_8847;ESR1_33192 56.24915 56.24915 46.45967324040282 39.31765 39.31765 29.711000599861997 69.02680000000001 69.02680000000001 52.483162355940394 89.1011;23.3972 60.3265;18.3088 106.138;31.9156 0 Exp 2,2(0.67);Poly 2,1(0.34) 2.227029633483993 6.804614543914795 1.6973176002502441 2.6703107357025146 0.5079805813409372 2.436986207962036 15.990576060232542 91.09469060643413 14.924201837048717 62.528198162951284 27.06988960461468 111.060577062052 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0071312 6 cellular response to alkaloid 21 22 4 4 4 3 3 3 159 19 2366 0.95308 0.16066 0.16066 13.64 83516;81869;24330 ppargc1a;gstm7;egr1 PPARGC1A_33189;GSTM7_8761;EGR1_8533 28.491539 42.3152 0.750017 24.02490896064672 26.75169615506404 24.676763082822003 19.296106333333334 26.2988 0.186019 16.745479059681163 18.020497966852467 17.104701038134902 50.34379333333334 64.5991 4.70178 40.44460720949251 47.734476207305505 41.671407932033134 0.5 21.5326085 1.5 42.3623 42.4094;42.3152;0.750017 26.2988;31.4035;0.186019 81.7305;64.5991;4.70178 1 2 1 81869 GSTM7_8761 42.3152 42.3152 31.4035 31.4035 64.5991 64.5991 42.3152 31.4035 64.5991 2 83516;24330 PPARGC1A_33189;EGR1_8533 21.5797085 21.5797085 29.457632219347577 13.2424095 13.2424095 18.464524520739236 43.21614 43.21614 54.467530258119844 42.4094;0.750017 26.2988;0.186019 81.7305;4.70178 0 Exp 2,1(0.34);Hill,1(0.34);Linear,1(0.34) 2.3498811028936557 7.7260613441467285 1.7501527070999146 4.21828556060791 1.422825560283736 1.7576230764389038 1.3047951948561511 55.67828280514384 0.34681292141365816 38.24539974525301 4.576411808381735 96.11117485828494 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0009152 8 purine ribonucleotide biosynthetic process 31 36 8 8 6 7 5 5 157 31 2354 0.97612 0.07456 0.07456 13.89 298490;24651;294103;100359982;25028 ppcs;pklr;papss2;mpc2;ampd1 PPCS_9540;PKLR_9489;PAPSS2_33237;MPC2_33219;AMPD1_32743 37.12534 34.4443 20.3353 16.925224486192196 39.61819282762819 18.278450466870346 29.171699999999998 25.719 16.7643 14.000184860743813 31.41203600974294 15.259752137174997 52.30126 51.1014 25.6711 23.92805574514986 55.38787973119915 25.461456291211256 0.5 21.7158 2.5 40.6453 20.3353;23.0963;34.4443;46.8463;60.9045 16.7643;17.4625;25.719;35.8494;50.0633 25.6711;32.9443;51.1014;69.127;82.6625 3 2 3 298490;100359982;25028 PPCS_9540;MPC2_33219;AMPD1_32743 42.695366666666665 46.8463 20.600671901987408 34.22566666666666 35.8494 16.708777115735714 59.153533333333336 69.127 29.775954166127633 20.3353;46.8463;60.9045 16.7643;35.8494;50.0633 25.6711;69.127;82.6625 2 24651;294103 PKLR_9489;PAPSS2_33237 28.7703 28.7703 8.024247752904948 21.59075 21.59075 5.8382271388667295 42.02285 42.02285 12.83900853668224 23.0963;34.4443 17.4625;25.719 32.9443;51.1014 0 Exp 2,5(1) 2.0349315613360255 10.368184804916382 1.571676254272461 2.6967689990997314 0.45377459971515605 1.9223796129226685 22.289726625656684 51.96095337434332 16.899996901894866 41.44340309810514 31.327394387500675 73.27512561249932 UP 0.6 0.4 0.0 GO:0031347 6 regulation of defense response 154 164 14 13 10 13 10 10 152 154 2231 0.52597 0.60595 1.0 6.1 79426;312688;25493;24539;65164;63868;29328;24890;25423;25373 zfp36;usp18;nfkbia;lpl;htra1;hspd1;gpx4;esr1;ctsc;ahsg ZFP36_10204;USP18_10138;NFKBIA_9307;LPL_32544;HTRA1_8856;HSPD1_8849;GPX4_32827;ESR1_33192;CTSC_32456;AHSG_8003 39.73037849999999 37.6951 0.348134 34.04784117203017 48.202983825736645 28.925547814428022 27.394730400000004 24.7807 0.118102 22.701337698510592 32.95229752041145 19.13172380916882 66.731581 58.546049999999994 1.15962 55.95805152761891 86.372885215472 52.840026323072664 7.5 65.22135 0.348134;108.883;0.520151;74.2041;33.1323;42.2579;45.9204;23.3972;56.2386;12.402 0.118102;73.1414;0.160202;49.8682;25.6145;23.9469;34.2198;18.3088;38.2681;10.3013 1.15962;138.144;2.88499;155.425;46.6629;102.383;70.4292;31.9156;102.888;15.4235 4 6 4 312688;24539;63868;29328 USP18_10138;LPL_32544;HSPD1_8849;GPX4_32827 67.81635 60.06225 30.87577305423568 45.294075 42.044 21.40667790221469 116.5953 120.2635 37.88311116350755 108.883;74.2041;42.2579;45.9204 73.1414;49.8682;23.9469;34.2198 138.144;155.425;102.383;70.4292 6 79426;25493;65164;24890;25423;25373 ZFP36_10204;NFKBIA_9307;HTRA1_8856;ESR1_33192;CTSC_32456;AHSG_8003 21.006397500000002 17.8996 21.515331017052556 15.461834000000001 14.305050000000001 15.016715858614836 33.48910166666667 23.66955 38.21100616111144 0.348134;0.520151;33.1323;23.3972;56.2386;12.402 0.118102;0.160202;25.6145;18.3088;38.2681;10.3013 1.15962;2.88499;46.6629;31.9156;102.888;15.4235 0 Exp 2,5(0.5);Exp 3,1(0.1);Exp 4,1(0.1);Hill,1(0.1);Linear,1(0.1);Power,1(0.1) 1.9209267094375233 19.85951793193817 1.547789216041565 3.431420087814331 0.5950625696848973 1.7799724340438843 18.627307907006657 60.83344909299335 13.324295520252088 41.465165279747914 32.04842133454129 101.41474066545872 DOWN 0.4 0.6 0.0 GO:0034605 5 cellular response to heat 21 23 3 3 3 2 2 2 160 21 2364 0.82335 0.43545 0.65454 8.7 63868;114851 hspd1;cdkn1a HSPD1_8849;CDKN1A_8271 24.253785 24.253785 6.24967 25.461663611524877 20.831633336420776 24.997481270107475 13.193575 13.193575 2.44025 15.20749805560566 11.149625100893152 14.930255682041489 60.7218 60.7218 19.0606 58.917834064737974 52.803002275884886 57.84372443134256 0.5 24.253785 42.2579;6.24967 23.9469;2.44025 102.383;19.0606 1 1 1 63868 HSPD1_8849 42.2579 42.2579 23.9469 23.9469 102.383 102.383 42.2579 23.9469 102.383 1 114851 CDKN1A_8271 6.24967 6.24967 2.44025 2.44025 19.0606 19.0606 6.24967 2.44025 19.0606 0 Exp 3,1(0.5);Exp 4,1(0.5) 1.8513647415392411 3.7739548683166504 1.522104263305664 2.2518506050109863 0.5160085867659089 1.8869774341583252 -11.034280399999993 59.541850399999994 -7.882942 34.270092 -20.93415199999997 142.377752 CONFLICT 0.5 0.5 0.0 GO:2000112 7 regulation of cellular macromolecule biosynthetic process 538 577 42 42 33 34 28 28 134 549 1836 0.052864 0.96591 0.099229 4.85 79426;24522;246273;24825;293615;25106;192280;83516;303612;25513;81819;25591;81525;25493;58954;24516;494344;290556;25112;294515;314322;24890;116636;24330;25695;114851;29184;79431 zfp36;zfp354a;trib3;tf;sirt3;rgn;ppp1r3b;ppargc1a;polg2;pik3r1;pax8;parp1;nfkbib;nfkbia;klf6;jun;ier2;gnl3;gadd45a;foxo3;fos;esr1;eif4ebp1;egr1;cebpd;cdkn1a;cd36;bhlhe40 ZFP36_10204;ZFP354A_10203;TRIB3_10079;TF_10003;SIRT3_9828;RGN_9699;PPP1R3B_9545;PPARGC1A_33189;POLG2_9521;PIK3R1_32562;PAX8_9432;PARP1_9425;NFKBIB_9308;NFKBIA_9307;KLF6_8969;JUN_8938;IER2_32643;GNL3_8735;GADD45A_8678;FOXO3_8662;FOS_8657;ESR1_33192;EIF4EBP1_8550;EGR1_8533;CEBPD_8283;CDKN1A_8271;CD36_8243;BHLHE40_8141 36.4136541071429 28.76565 1.28141E-12 33.24624526850353 38.059311238283826 32.449502356881254 25.486862400000046 23.02145 1.28141E-12 24.960113854099678 27.4596908591092 25.399220847702914 60.17146500000003 43.57295 1.28142E-12 55.346338565880316 57.08761570230386 44.35794153812963 0.348134;0.834827;108.064;45.1539;2.38018;77.4407;36.1411;42.4094;63.7758;18.7324;56.8931;26.9741;30.5572;0.520151;18.9476;16.4324;49.6814;87.6357;102.919;13.1992;1.28141E-12;23.3972;83.9001;0.750017;0.306936;6.24967;48.1296;57.8085 0.118102;0.27095;83.8836;28.132;0.56209;58.7732;27.0588;26.2988;40.9553;11.6701;45.1162;21.799;24.2439;0.160202;11.6941;10.5224;33.4626;54.41;89.5012;5.6804;1.28141E-12;18.3088;42.4185;0.186019;0.0732342;2.44025;37.5433;38.3491 1.15962;2.99857;143.428;61.5341;8.82917;89.8047;53.6244;81.7305;132.567;41.5978;81.5688;35.2797;41.2611;2.88499;45.5481;39.929;89.4404;238.963;115.437;32.7581;1.28142E-12;31.9156;107.32;4.70178;1.73689;19.0606;69.1421;110.58 9 19 9 24825;293615;25106;81819;25591;81525;290556;116636;29184 TF_10003;SIRT3_9828;RGN_9699;PAX8_9432;PARP1_9425;NFKBIB_9308;GNL3_8735;EIF4EBP1_8550;CD36_8243 51.00717555555556 48.1296 28.63539068193199 34.77757666666667 37.5433 18.125972615094337 81.5225188888889 69.1421 66.25530787608234 45.1539;2.38018;77.4407;56.8931;26.9741;30.5572;87.6357;83.9001;48.1296 28.132;0.56209;58.7732;45.1162;21.799;24.2439;54.41;42.4185;37.5433 61.5341;8.82917;89.8047;81.5688;35.2797;41.2611;238.963;107.32;69.1421 19 79426;24522;246273;192280;83516;303612;25513;25493;58954;24516;494344;25112;294515;314322;24890;24330;25695;114851;79431 ZFP36_10204;ZFP354A_10203;TRIB3_10079;PPP1R3B_9545;PPARGC1A_33189;POLG2_9521;PIK3R1_32562;NFKBIA_9307;KLF6_8969;JUN_8938;IER2_32643;GADD45A_8678;FOXO3_8662;FOS_8657;ESR1_33192;EGR1_8533;CEBPD_8283;CDKN1A_8271;BHLHE40_8141 29.500933421052697 18.7324 33.7135772282125 21.085997747368488 11.6701 26.923707709755305 50.05780789473691 39.929 48.040778376973414 0.348134;0.834827;108.064;36.1411;42.4094;63.7758;18.7324;0.520151;18.9476;16.4324;49.6814;102.919;13.1992;1.28141E-12;23.3972;0.750017;0.306936;6.24967;57.8085 0.118102;0.27095;83.8836;27.0588;26.2988;40.9553;11.6701;0.160202;11.6941;10.5224;33.4626;89.5012;5.6804;1.28141E-12;18.3088;0.186019;0.0732342;2.44025;38.3491 1.15962;2.99857;143.428;53.6244;81.7305;132.567;41.5978;2.88499;45.5481;39.929;89.4404;115.437;32.7581;1.28142E-12;31.9156;4.70178;1.73689;19.0606;110.58 0 Exp 2,11(0.4);Exp 3,1(0.04);Exp 4,3(0.11);Hill,6(0.22);Poly 2,7(0.25) 1.9003986780354198 55.56034302711487 1.5209722518920898 4.591650485992432 0.7319386621914226 1.7612056136131287 24.099072526146365 48.72823568813944 16.241506846467253 34.732217953532846 39.670894304737715 80.67203569526241 DOWN 0.32142857142857145 0.6785714285714286 0.0 GO:0006950 3 response to stress 773 821 82 82 64 74 57 57 105 764 1621 0.82091 0.22736 0.43439 6.94 79426;24522;246273;24825;29482;24648;246074;83516;303612;24651;25513;25591;24314;24539;288001;58954;24516;81678;54404;192235;63868;24471;24464;29328;24957;25112;294515;314322;25661;25256;361969;24360;308441;295143;29496;65030;116636;24330;116663;140942;25146;497840;113936;114851;29184;54232;313421;246142;25698;155423;65183;25373;192272;24158;25287;170465;25303 zfp36;zfp354a;trib3;tf;slc1a2;serpina1;scd;ppargc1a;polg2;pklr;pik3r1;parp1;nqo1;lpl;kng1;klf6;jun;itpr2;itih4;hyou1;hspd1;hspb1;hp;gpx4;glul;gadd45a;foxo3;fos;fn1;fmo1;fga;fabp1;exosc5;etfdh;erbb3;ephx2;eif4ebp1;egr1;dusp6;ddit4;cyp17a1;cps1;cpb2;cdkn1a;cd36;car3;c8b;bmf;ass1;anxa7;aldh3a2;ahsg;acot2;acadm;acadl;acaa2;abcc2 ZFP36_10204;ZFP354A_10203;TRIB3_10079;TF_10003;SLC1A2_33059;SERPINA1_9807;SCD1_9787;PPARGC1A_33189;POLG2_9521;PKLR_9489;PIK3R1_32562;PARP1_9425;NQO1_33055;LPL_32544;KNG1L1_34113;KLF6_8969;JUN_8938;ITPR2_8931;ITIH4_32725;HYOU1_8857;HSPD1_8849;HSPB1_8847;HP_8823;GPX4_32827;GLUL_32832;GADD45A_8678;FOXO3_8662;FOS_8657;FN1_8655;FMO1_32787;FGA_8632;FABP1_33091;EXOSC5_32543;ETFDH_8575;ERBB3_8571;EPHX2_33282;EIF4EBP1_8550;EGR1_8533;DUSP6_8506;DDIT4_8450;CYP17A1_32365;CPS1_32421;CPB2_8369;CDKN1A_8271;CD36_8243;CAR3_8196;C8B_8181;BMF_8152;ASS1_33159;ANXA7_8051;ALDH3A2_8024;AHSG_8003;ACOT2_7969;ACADM_7957;ACADL_32776;ACAA2_7955;ABCC2_32541 42.568036807017556 38.7293 1.28141E-12 29.76957168270874 45.673613723838955 29.700890070652896 28.987452824561423 26.4736 1.28141E-12 20.099929274720964 31.14227622756604 20.887742838835237 73.38723807017547 57.2113 1.28142E-12 68.70144270092395 74.51212418903818 60.34479652291061 40.5 58.347 0.348134;0.834827;108.064;45.1539;13.3235;15.797;105.46;42.4094;63.7758;23.0963;18.7324;26.9741;87.2765;74.2041;24.3655;18.9476;16.4324;31.8111;57.1163;40.1982;42.2579;89.1011;64.9285;45.9204;26.4669;102.919;13.1992;1.28141E-12;59.5777;65.2792;28.5803;33.8478;41.9329;18.1231;60.9984;38.7293;83.9001;0.750017;62.3934;87.5421;49.6922;31.9826;25.8316;6.24967;48.1296;53.9626;21.3618;94.8767;26.8037;104.64;43.1079;12.402;8.54905;11.7137;33.4878;26.5872;46.2316 0.118102;0.27095;83.8836;28.132;9.10952;13.013;63.7532;26.2988;40.9553;17.4625;11.6701;21.799;60.6992;49.8682;19.538;11.6941;10.5224;24.7342;39.6402;29.3844;23.9469;60.3265;41.6103;34.2198;21.0456;89.5012;5.6804;1.28141E-12;31.0499;39.7882;22.529;26.4736;31.7336;14.869;41.6036;29.2097;42.4185;0.186019;39.0875;53.2453;35.6654;24.4836;20.4374;2.44025;37.5433;28.5034;17.2088;73.1342;20.9825;43.9254;31.8774;10.3013;7.19676;8.36151;26.6039;21.3695;31.1788 1.15962;2.99857;143.428;61.5341;24.6773;19.9134;422.699;81.7305;132.567;32.9443;41.5978;35.2797;197.117;155.425;32.1467;45.5481;39.929;44.3296;101.869;62.3571;102.383;106.138;136.455;70.4292;35.4303;115.437;32.7581;1.28142E-12;105.243;82.9415;38.8511;46.9257;62.1373;23.0103;113.972;57.2113;107.32;4.70178;133.304;245.492;81.6409;45.5891;34.8042;19.0606;69.1421;77.0288;27.9161;109.848;36.7081;108.689;66.3058;15.4235;10.4125;18.9642;45.3228;35.0407;81.7848 23 34 23 24825;246074;25591;24314;24539;63868;29328;25256;24360;308441;295143;29496;65030;116636;25146;29184;246142;155423;65183;192272;24158;25287;170465 TF_10003;SCD1_9787;PARP1_9425;NQO1_33055;LPL_32544;HSPD1_8849;GPX4_32827;FMO1_32787;FABP1_33091;EXOSC5_32543;ETFDH_8575;ERBB3_8571;EPHX2_33282;EIF4EBP1_8550;CYP17A1_32365;CD36_8243;BMF_8152;ANXA7_8051;ALDH3A2_8024;ACOT2_7969;ACADM_7957;ACADL_32776;ACAA2_7955 51.775732608695655 45.1539 28.31404397912331 34.530081304347824 31.8774 16.487700069674066 90.59787391304347 69.1421 84.77273366249325 45.1539;105.46;26.9741;87.2765;74.2041;42.2579;45.9204;65.2792;33.8478;41.9329;18.1231;60.9984;38.7293;83.9001;49.6922;48.1296;94.8767;104.64;43.1079;8.54905;11.7137;33.4878;26.5872 28.132;63.7532;21.799;60.6992;49.8682;23.9469;34.2198;39.7882;26.4736;31.7336;14.869;41.6036;29.2097;42.4185;35.6654;37.5433;73.1342;43.9254;31.8774;7.19676;8.36151;26.6039;21.3695 61.5341;422.699;35.2797;197.117;155.425;102.383;70.4292;82.9415;46.9257;62.1373;23.0103;113.972;57.2113;107.32;81.6409;69.1421;109.848;108.689;66.3058;10.4125;18.9642;45.3228;35.0407 34 79426;24522;246273;29482;24648;83516;303612;24651;25513;288001;58954;24516;81678;54404;192235;24471;24464;24957;25112;294515;314322;25661;361969;24330;116663;140942;497840;113936;114851;54232;313421;25698;25373;25303 ZFP36_10204;ZFP354A_10203;TRIB3_10079;SLC1A2_33059;SERPINA1_9807;PPARGC1A_33189;POLG2_9521;PKLR_9489;PIK3R1_32562;KNG1L1_34113;KLF6_8969;JUN_8938;ITPR2_8931;ITIH4_32725;HYOU1_8857;HSPB1_8847;HP_8823;GLUL_32832;GADD45A_8678;FOXO3_8662;FOS_8657;FN1_8655;FGA_8632;EGR1_8533;DUSP6_8506;DDIT4_8450;CPS1_32421;CPB2_8369;CDKN1A_8271;CAR3_8196;C8B_8181;ASS1_33159;AHSG_8003;ABCC2_32541 36.33930141176476 26.6353 29.502224493950568 25.23802767647063 21.01405 21.644001184395705 61.74474911764711 40.763400000000004 53.595348704247854 0.348134;0.834827;108.064;13.3235;15.797;42.4094;63.7758;23.0963;18.7324;24.3655;18.9476;16.4324;31.8111;57.1163;40.1982;89.1011;64.9285;26.4669;102.919;13.1992;1.28141E-12;59.5777;28.5803;0.750017;62.3934;87.5421;31.9826;25.8316;6.24967;53.9626;21.3618;26.8037;12.402;46.2316 0.118102;0.27095;83.8836;9.10952;13.013;26.2988;40.9553;17.4625;11.6701;19.538;11.6941;10.5224;24.7342;39.6402;29.3844;60.3265;41.6103;21.0456;89.5012;5.6804;1.28141E-12;31.0499;22.529;0.186019;39.0875;53.2453;24.4836;20.4374;2.44025;28.5034;17.2088;20.9825;10.3013;31.1788 1.15962;2.99857;143.428;24.6773;19.9134;81.7305;132.567;32.9443;41.5978;32.1467;45.5481;39.929;44.3296;101.869;62.3571;106.138;136.455;35.4303;115.437;32.7581;1.28142E-12;105.243;38.8511;4.70178;133.304;245.492;45.5891;34.8042;19.0606;77.0288;27.9161;36.7081;15.4235;81.7848 0 Exp 2,23(0.41);Exp 3,3(0.06);Exp 4,2(0.04);Hill,4(0.08);Linear,12(0.22);Poly 2,12(0.22);Power,1(0.02) 1.995251083824309 125.30076444149017 1.5122476816177368 11.836054801940918 1.496947583737536 1.7706087827682495 34.83960766087345 50.29646595316171 23.76934351154041 34.20556213758245 55.55177043862838 91.22270570172253 CONFLICT 0.40350877192982454 0.5964912280701754 0.0 GO:0009056 3 catabolic process 364 413 65 65 47 55 40 40 122 373 2012 0.99857 0.0026869 0.0039843 9.69 79426;312688;286954;360268;65192;29676;83516;29441;24651;24539;289456;24443;171155;113965;85255;81869;114860;308441;295143;65030;25315;171142;291075;29740;25428;65210;24894;83842;497840;81718;29184;155423;25377;50681;192272;24158;25287;170465;25303;296925 zfp36;usp18;ugt2b1;sult1e1;slc27a2;psmb3;ppargc1a;por;pklr;lpl;hsd17b11;hdc;hadhb;hadh;hacl1;gstm7;gale;exosc5;etfdh;ephx2;ephx1;ehhadh;eci2;eci1;cyp7a1;cyp2j4;cyp2a1;crot;cps1;cdo1;cd36;anxa7;ambp;acox1;acot2;acadm;acadl;acaa2;abcc2;aass ZFP36_10204;USP18_10138;UGT2B10_33303,UGT2B1_33224;SULT1E1_32446;SLC27A2_9860;PSMB3_9589;PPARGC1A_33189;POR_9531;PKLR_9489;LPL_32544;HSD17B11_8832;HDC_8788;HADHB_8777;HADH_8776;HACL1_8775;GSTM7_8761;GALE_8680;EXOSC5_32543;ETFDH_8575;EPHX2_33282;EPHX1_8567;EHHADH_8534;ECI2_8521;ECI1_8520;CYP7A1_8430;CYP2J4_32580;CYP2A1_32717;CROT_8384;CPS1_32421;CDO1_8275;CD36_8243;ANXA7_8051;AMBP_33085;ACOX1_7973;ACOT2_7969;ACADM_7957;ACADL_32776;ACAA2_7955;ABCC2_32541;AASS_7936 31.617479850000002 24.181649999999998 0.348134 24.692313710301246 32.46310931084239 24.02154545568248 22.138444875000005 20.16715 0.118102 15.074858159918826 22.835321175621203 14.523892032280221 48.17943675 36.0351 1.15962 35.63032672445565 50.930670290298025 37.42451988284021 19.5 24.181649999999998 0.348134;108.883;47.47345;50.1846;7.62189;23.7888;42.4094;12.4414;23.0963;74.2041;22.4334;24.5745;31.8029;33.3125;17.6275;42.3152;71.148;41.9329;18.1231;38.7293;12.4747;8.62809;10.6467;11.9473;5.72128;17.8395;55.3937;7.4229;31.9826;22.9638;48.1296;104.64;17.2343;23.1906;8.54905;11.7137;33.4878;26.5872;46.2316;27.4644 0.118102;73.1414;34.82915;36.5009;5.49916;19.2724;26.2988;8.48981;17.4625;49.8682;18.1233;21.0619;25.5756;25.7336;11.195;31.4035;43.2839;31.7336;14.869;29.2097;7.00435;7.31865;8.92359;7.15307;0.985273;14.6501;38.7444;5.75707;24.4836;18.5144;37.5433;43.9254;14.1233;16.2815;7.19676;8.36151;26.6039;21.3695;31.1788;21.7498 1.15962;138.144;76.47475;80.9788;13.3925;30.901;81.7305;79.2355;32.9443;155.425;29.2247;29.28;42.1484;46.9856;37.6534;64.5991;88.9033;62.1373;23.0103;57.2113;23.684;10.3909;13.0581;19.001;22.3625;22.6149;96.8569;10.316;45.5891;30.0179;69.1421;108.689;21.9073;33.4539;10.4125;18.9642;45.3228;35.0407;81.7848;37.0295 31 10 30 312688;286954;360268;65192;29676;24539;289456;24443;171155;113965;85255;81869;308441;295143;65030;25315;171142;291075;29740;65210;24894;83842;29184;155423;50681;192272;24158;25287;170465;296925 USP18_10138;UGT2B10_33303,UGT2B1_33224;SULT1E1_32446;SLC27A2_9860;PSMB3_9589;LPL_32544;HSD17B11_8832;HDC_8788;HADHB_8777;HADH_8776;HACL1_8775;GSTM7_8761;EXOSC5_32543;ETFDH_8575;EPHX2_33282;EPHX1_8567;EHHADH_8534;ECI2_8521;ECI1_8520;CYP2J4_32580;CYP2A1_32717;CROT_8384;CD36_8243;ANXA7_8051;ACOX1_7973;ACOT2_7969;ACADM_7957;ACADL_32776;ACAA2_7955;AASS_7936 33.03741266666667 25.580849999999998 25.900941601407663 23.353310333333333 21.2157 15.590648088052653 48.05142166666667 36.0351 37.368909205564705 108.883;47.47345;50.1846;7.62189;23.7888;74.2041;22.4334;24.5745;31.8029;33.3125;17.6275;42.3152;41.9329;18.1231;38.7293;12.4747;8.62809;10.6467;11.9473;17.8395;55.3937;7.4229;48.1296;104.64;23.1906;8.54905;11.7137;33.4878;26.5872;27.4644 73.1414;34.82915;36.5009;5.49916;19.2724;49.8682;18.1233;21.0619;25.5756;25.7336;11.195;31.4035;31.7336;14.869;29.2097;7.00435;7.31865;8.92359;7.15307;14.6501;38.7444;5.75707;37.5433;43.9254;16.2815;7.19676;8.36151;26.6039;21.3695;21.7498 138.144;76.47475;80.9788;13.3925;30.901;155.425;29.2247;29.28;42.1484;46.9856;37.6534;64.5991;62.1373;23.0103;57.2113;23.684;10.3909;13.0581;19.001;22.6149;96.8569;10.316;69.1421;108.689;33.4539;10.4125;18.9642;45.3228;35.0407;37.0295 10 79426;83516;29441;24651;114860;25428;497840;81718;25377;25303 ZFP36_10204;PPARGC1A_33189;POR_9531;PKLR_9489;GALE_8680;CYP7A1_8430;CPS1_32421;CDO1_8275;AMBP_33085;ABCC2_32541 27.3576814 23.03005 21.2964636984675 18.493848500000002 17.98845 13.485440284261763 48.56348200000001 39.2667 31.645071044285977 0.348134;42.4094;12.4414;23.0963;71.148;5.72128;31.9826;22.9638;17.2343;46.2316 0.118102;26.2988;8.48981;17.4625;43.2839;0.985273;24.4836;18.5144;14.1233;31.1788 1.15962;81.7305;79.2355;32.9443;88.9033;22.3625;45.5891;30.0179;21.9073;81.7848 0 Exp 2,17(0.42);Exp 3,1(0.03);Hill,5(0.13);Linear,11(0.27);Poly 2,5(0.13);Power,2(0.05) 2.6544069203231064 161.63051521778107 1.5461770296096802 32.73371124267578 5.683431435529139 1.9288111925125122 23.965252551652405 39.26970714834759 17.46669793044681 26.8101918195532 37.13748409992584 59.22138940007416 UP 0.75 0.25 0.0 GO:0010866 7 regulation of triglyceride biosynthetic process 13 13 2 2 2 2 2 2 160 11 2374 0.95495 0.19842 0.19842 15.38 25357;25106 thrsp;rgn THRSP_33314;RGN_9699 54.82300000000001 54.82300000000001 32.2053 31.986258089685936 57.68113274499189 31.729841805530786 41.584900000000005 41.584900000000005 24.3966 24.30792697413746 43.756935311315644 24.113063658373992 68.20575 68.20575 46.6068 30.545528023018385 70.93514628045479 30.300661281455195 0.0 32.2053 0.5 54.82300000000001 32.2053;77.4407 24.3966;58.7732 46.6068;89.8047 1 1 1 25106 RGN_9699 77.4407 77.4407 58.7732 58.7732 89.8047 89.8047 77.4407 58.7732 89.8047 1 25357 THRSP_33314 32.2053 32.2053 24.3966 24.3966 46.6068 46.6068 32.2053 24.3966 46.6068 0 Exp 2,1(0.5);Poly 2,1(0.5) 2.212578482774241 4.566297292709351 1.7198865413665771 2.8464107513427734 0.7965729080449866 2.2831486463546753 10.492308000000001 99.153692 7.895832000000006 75.273968 25.871808 110.53969199999999 CONFLICT 0.5 0.5 0.0 GO:1905039 6 carboxylic acid transmembrane transport 23 23 4 3 3 3 2 2 160 21 2364 0.82335 0.43545 0.65454 8.7 29482;100359982 slc1a2;mpc2 SLC1A2_33059;MPC2_33219 30.084899999999998 30.084899999999998 13.3235 23.704199204360407 28.874232154763103 23.642284717366458 22.479460000000003 22.479460000000003 9.10952 18.90795047611454 21.51375567633094 18.858563612473088 46.90215 46.90215 24.6773 31.43068429170767 45.29685979391857 31.348588512938157 0.5 30.084899999999998 13.3235;46.8463 9.10952;35.8494 24.6773;69.127 1 1 1 100359982 MPC2_33219 46.8463 46.8463 35.8494 35.8494 69.127 69.127 46.8463 35.8494 69.127 1 29482 SLC1A2_33059 13.3235 13.3235 9.10952 9.10952 24.6773 24.6773 13.3235 9.10952 24.6773 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.7648978251408376 3.5426965951919556 1.620316982269287 1.9223796129226685 0.21359053447805346 1.7713482975959778 -2.767444000000001 62.93724400000001 -3.7256223999999953 48.6845424 3.3414440000000027 90.46285599999999 CONFLICT 0.5 0.5 0.0 GO:0051091 8 positive regulation of DNA-binding transcription factor activity 80 84 4 4 4 4 4 4 158 80 2305 0.37175 0.79384 0.81847 4.76 83516;24516;24890;29184 ppargc1a;jun;esr1;cd36 PPARGC1A_33189;JUN_8938;ESR1_33192;CD36_8243 32.592150000000004 32.9033 16.4324 15.093877076814943 38.6451551515767 14.330944107825967 23.168325000000003 22.303800000000003 10.5224 11.546632731486406 27.834014665109432 11.850355152911396 55.6793 54.53555 31.9156 23.612831208617642 64.15110442289138 19.81095238364359 42.4094;16.4324;23.3972;48.1296 26.2988;10.5224;18.3088;37.5433 81.7305;39.929;31.9156;69.1421 1 3 1 29184 CD36_8243 48.1296 48.1296 37.5433 37.5433 69.1421 69.1421 48.1296 37.5433 69.1421 3 83516;24516;24890 PPARGC1A_33189;JUN_8938;ESR1_33192 27.413 23.3972 13.446044752268222 18.37666666666667 18.3088 7.888418957771788 51.191700000000004 39.929 26.749156509505124 42.4094;16.4324;23.3972 26.2988;10.5224;18.3088 81.7305;39.929;31.9156 0 Exp 2,3(0.75);Poly 2,1(0.25) 2.1810694236605257 8.843425869941711 1.7576230764389038 2.6703107357025146 0.4169892885880364 2.2077460289001465 17.800150464721348 47.38414953527866 11.852624923143317 34.48402507685668 32.53872541555472 78.81987458444529 DOWN 0.25 0.75 0.0 GO:1905179 7 negative regulation of cardiac muscle tissue regeneration 2 2 1 1 1 1 1 1 161 1 2384 0.99598 0.12319 0.12319 50.0 114851 cdkn1a CDKN1A_8271 6.24967 6.24967 6.24967 6.24967 2.44025 2.44025 2.44025 2.44025 19.0606 19.0606 19.0606 19.0606 0.0 6.24967 0.0 6.24967 6.24967 2.44025 19.0606 0 1 0 1 114851 CDKN1A_8271 6.24967 6.24967 2.44025 2.44025 19.0606 19.0606 6.24967 2.44025 19.0606 0 Exp 4,1(1) 1.522104263305664 1.522104263305664 1.522104263305664 1.522104263305664 0.0 1.522104263305664 6.24967 6.24967 2.44025 2.44025 19.0606 19.0606 DOWN 0.0 1.0 0.0 GO:0015893 5 drug transport 30 33 5 4 4 4 3 3 159 30 2355 0.8458 0.35094 0.46366 9.09 361074;29482;312382 slc25a30;slc1a2;abcg2 SLC25A30_9856;SLC1A2_33059;ABCG2_32656 23.85101333333333 13.3235 5.21654 25.578248569253784 26.77496524447158 27.14327052283148 16.4412 9.10952 2.73368 18.49726429519782 18.517706100231173 19.650831161635413 42.10756666666666 24.6773 11.386 42.22693398701039 46.94148909582589 44.80659133942963 0.5 9.270019999999999 53.013;13.3235;5.21654 37.4804;9.10952;2.73368 90.2594;24.6773;11.386 2 1 2 361074;312382 SLC25A30_9856;ABCG2_32656 29.11477 29.11477 33.79720098271157 20.10704 20.10704 24.569641335990237 50.8227 50.8227 55.771915995239034 53.013;5.21654 37.4804;2.73368 90.2594;11.386 1 29482 SLC1A2_33059 13.3235 13.3235 9.10952 9.10952 24.6773 24.6773 13.3235 9.10952 24.6773 0 Exp 4,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 2.073313927860557 6.776605606079102 1.5074360370635986 3.648852586746216 1.2050839283134125 1.620316982269287 -5.093499712508017 52.79552637917469 -4.490425019404064 37.37282501940407 -5.6767074740612244 89.89184080739454 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0019448 8 L-cysteine catabolic process 1 1 1 1 1 1 1 1 161 0 2385 1.0 0.063604 0.063604 100.0 81718 cdo1 CDO1_8275 22.9638 22.9638 22.9638 22.9638 18.5144 18.5144 18.5144 18.5144 30.0179 30.0179 30.0179 30.0179 0.0 22.9638 0.0 22.9638 22.9638 18.5144 30.0179 0 1 0 1 81718 CDO1_8275 22.9638 22.9638 18.5144 18.5144 30.0179 30.0179 22.9638 18.5144 30.0179 0 Linear,1(1) 2.008971929550171 2.008971929550171 2.008971929550171 2.008971929550171 0.0 2.008971929550171 22.9638 22.9638 18.5144 18.5144 30.0179 30.0179 DOWN 0.0 1.0 0.0 GO:0046439 8 L-cysteine metabolic process 1 1 1 1 1 1 1 1 161 0 2385 1.0 0.063604 0.063604 100.0 81718 cdo1 CDO1_8275 22.9638 22.9638 22.9638 22.9638 18.5144 18.5144 18.5144 18.5144 30.0179 30.0179 30.0179 30.0179 0.0 22.9638 0.0 22.9638 22.9638 18.5144 30.0179 0 1 0 1 81718 CDO1_8275 22.9638 22.9638 18.5144 18.5144 30.0179 30.0179 22.9638 18.5144 30.0179 0 Linear,1(1) 2.008971929550171 2.008971929550171 2.008971929550171 2.008971929550171 0.0 2.008971929550171 22.9638 22.9638 18.5144 18.5144 30.0179 30.0179 DOWN 0.0 1.0 0.0 GO:0043549 7 regulation of kinase activity 234 250 18 18 15 17 14 14 148 236 2149 0.36156 0.73777 0.68362 5.6 246273;24825;25106;25513;24471;25675;29455;299626;25112;29496;24330;116663;114851;25373 trib3;tf;rgn;pik3r1;hspb1;hmgcr;gdf15;gadd45b;gadd45a;erbb3;egr1;dusp6;cdkn1a;ahsg TRIB3_10079;TF_10003;RGN_9699;PIK3R1_32562;HSPB1_8847;HMGCR_8810;GDF15_33113;GADD45B_8679;GADD45A_8678;ERBB3_8571;EGR1_8533;DUSP6_8506;CDKN1A_8271;AHSG_8003 56.953676928571426 61.695899999999995 0.750017 42.393738773018434 59.46539055733587 41.28284586616352 40.33073614285714 40.34555 0.186019 32.499069513301144 43.83840310992865 33.67257651991898 77.65114857142858 97.97135 4.70178 50.78897009421917 80.63682347323528 48.87584141170199 11.5 105.75800000000001 108.064;45.1539;77.4407;18.7324;89.1011;1.63089;105.149;106.367;102.919;60.9984;0.750017;62.3934;6.24967;12.402 83.8836;28.132;58.7732;11.6701;60.3265;0.663137;85.3487;52.7132;89.5012;41.6036;0.186019;39.0875;2.44025;10.3013 143.428;61.5341;89.8047;41.5978;106.138;7.6286;125.652;109.434;115.437;113.972;4.70178;133.304;19.0606;15.4235 4 10 4 24825;25106;299626;29496 TF_10003;RGN_9699;GADD45B_8679;ERBB3_8571 72.49000000000001 69.21955 26.15007835080674 45.3055 47.1584 13.476969595573046 93.68619999999999 99.61935 23.86301505915245 45.1539;77.4407;106.367;60.9984 28.132;58.7732;52.7132;41.6036 61.5341;89.8047;109.434;113.972 10 246273;25513;24471;25675;29455;25112;24330;116663;114851;25373 TRIB3_10079;PIK3R1_32562;HSPB1_8847;HMGCR_8810;GDF15_33113;GADD45A_8678;EGR1_8533;DUSP6_8506;CDKN1A_8271;AHSG_8003 50.739147700000004 40.5629 47.094214395904935 38.3408306 25.3788 38.07446983525643 71.237128 73.8679 58.10482359274349 108.064;18.7324;89.1011;1.63089;105.149;102.919;0.750017;62.3934;6.24967;12.402 83.8836;11.6701;60.3265;0.663137;85.3487;89.5012;0.186019;39.0875;2.44025;10.3013 143.428;41.5978;106.138;7.6286;125.652;115.437;4.70178;133.304;19.0606;15.4235 0 Exp 2,2(0.15);Exp 4,2(0.15);Hill,1(0.08);Linear,1(0.08);Poly 2,7(0.5);Power,1(0.08) 1.8879720960994617 27.860277771949768 1.522104263305664 4.21828556060791 0.8011669910028397 1.6854488253593445 34.746478511947345 79.16087534519554 23.306682451775917 57.35478983393837 51.04625905467393 104.2560380881832 DOWN 0.2857142857142857 0.7142857142857143 0.0 GO:0033875 7 ribonucleoside bisphosphate metabolic process 38 41 19 19 12 17 11 11 151 30 2355 1.0 2.9255E-5 2.9255E-5 26.83 360268;298490;294103;100359982;25675;83842;192272;170570;50559;170465;296925 sult1e1;ppcs;papss2;mpc2;hmgcr;crot;acot2;acot12;acot1;acaa2;aass SULT1E1_32446;PPCS_9540;PAPSS2_33237;MPC2_33219;HMGCR_8810;CROT_8384;ACOT2_7969;ACOT12_32718;ACOT1_7968;ACAA2_7955;AASS_7936 25.909912727272726 27.4644 1.63089 15.539209255238248 29.881835228917545 11.744953237607461 20.222142454545455 21.7498 0.663137 11.725658606799206 23.669749583949436 8.667856166308992 36.879999999999995 37.0295 7.6286 23.65516507746248 41.219537342722816 19.223042356425555 1.5 7.985975 3.5 23.46125 50.1846;20.3353;34.4443;46.8463;1.63089;7.4229;8.54905;30.3423;31.2018;26.5872;27.4644 36.5009;16.7643;25.719;35.8494;0.663137;5.75707;7.19676;24.0157;26.858;21.3695;21.7498 80.9788;25.6711;51.1014;69.127;7.6286;10.316;10.4125;41.1025;37.2719;35.0407;37.0295 9 2 9 360268;298490;100359982;83842;192272;170570;50559;170465;296925 SULT1E1_32446;PPCS_9540;MPC2_33219;CROT_8384;ACOT2_7969;ACOT12_32718;ACOT1_7968;ACAA2_7955;AASS_7936 27.659316666666662 27.4644 14.683408173768807 21.784603333333333 21.7498 10.840716099538811 38.550000000000004 37.0295 23.750462175766174 50.1846;20.3353;46.8463;7.4229;8.54905;30.3423;31.2018;26.5872;27.4644 36.5009;16.7643;35.8494;5.75707;7.19676;24.0157;26.858;21.3695;21.7498 80.9788;25.6711;69.127;10.316;10.4125;41.1025;37.2719;35.0407;37.0295 2 294103;25675 PAPSS2_33237;HMGCR_8810 18.037595 18.037595 23.202584724854468 13.1910685 13.1910685 17.717170635781113 29.365 29.365 30.73991167716654 34.4443;1.63089 25.719;0.663137 51.1014;7.6286 0 Exp 2,7(0.64);Exp 4,1(0.1);Linear,2(0.19);Poly 2,1(0.1) 4.143590900372457 378.1557844877243 1.7093055248260498 344.14306640625 102.78318850630177 1.9288111925125122 16.726826889877387 35.09299856466806 13.292721033057578 27.151563876033332 22.900690767719254 50.85930923228075 UP 0.8181818181818182 0.18181818181818182 0.0 GO:0043525 8 positive regulation of neuron apoptotic process 36 38 4 4 4 4 4 4 158 34 2351 0.91021 0.2196 0.30037 10.53 24314;24516;294515;24330 nqo1;jun;foxo3;egr1 NQO1_33055;JUN_8938;FOXO3_8662;EGR1_8533 29.41452925 14.8158 0.750017 39.162628887558384 14.10844448666719 26.79544116955294 19.27200475 8.1014 0.186019 27.939068591563498 8.906210793125148 18.78043805165445 68.62647 36.34355 4.70178 86.99859585482744 34.558364773066934 59.59641675586335 0.5 6.9746084999999995 2.5 51.85445 87.2765;16.4324;13.1992;0.750017 60.6992;10.5224;5.6804;0.186019 197.117;39.929;32.7581;4.70178 1 3 1 24314 NQO1_33055 87.2765 87.2765 60.6992 60.6992 197.117 197.117 87.2765 60.6992 197.117 3 24516;294515;24330 JUN_8938;FOXO3_8662;EGR1_8533 10.127205666666667 13.1992 8.28022620631202 5.462939666666666 5.6804 5.1716206156020705 25.796293333333335 32.7581 18.61690955234336 16.4324;13.1992;0.750017 10.5224;5.6804;0.186019 39.929;32.7581;4.70178 0 Exp 2,1(0.25);Exp 4,1(0.25);Hill,1(0.25);Poly 2,1(0.25) 2.2616762123239447 9.761863231658936 1.576730489730835 4.21828556060791 1.2006255755507795 1.9834235906600952 -8.964847059807205 67.7939055598072 -8.108282469732234 46.65229196973223 -16.63215393773089 153.8850939377309 DOWN 0.25 0.75 0.0 GO:0006979 4 response to oxidative stress 170 179 21 21 19 20 18 18 144 161 2224 0.98358 0.031749 0.054174 10.06 83516;25591;24314;58954;24516;63868;24471;24464;29328;294515;314322;25661;24360;295143;29184;54232;65183;25303 ppargc1a;parp1;nqo1;klf6;jun;hspd1;hspb1;hp;gpx4;foxo3;fos;fn1;fabp1;etfdh;cd36;car3;aldh3a2;abcc2 PPARGC1A_33189;PARP1_9425;NQO1_33055;KLF6_8969;JUN_8938;HSPD1_8849;HSPB1_8847;HP_8823;GPX4_32827;FOXO3_8662;FOS_8657;FN1_8655;FABP1_33091;ETFDH_8575;CD36_8243;CAR3_8196;ALDH3A2_8024;ABCC2_32541 41.69041111111118 42.75865 1.28141E-12 24.20233171338185 45.67155241698459 20.727356993589844 27.682933333333406 27.488500000000002 1.28141E-12 16.35662548891738 29.92672193629754 13.472358290121694 73.17822777777786 69.78565 1.28142E-12 46.059675257326205 76.30774515248163 35.89073849760935 7.5 42.33365 16.5 88.1888 42.4094;26.9741;87.2765;18.9476;16.4324;42.2579;89.1011;64.9285;45.9204;13.1992;1.28141E-12;59.5777;33.8478;18.1231;48.1296;53.9626;43.1079;46.2316 26.2988;21.799;60.6992;11.6941;10.5224;23.9469;60.3265;41.6103;34.2198;5.6804;1.28141E-12;31.0499;26.4736;14.869;37.5433;28.5034;31.8774;31.1788 81.7305;35.2797;197.117;45.5481;39.929;102.383;106.138;136.455;70.4292;32.7581;1.28142E-12;105.243;46.9257;23.0103;69.1421;77.0288;66.3058;81.7848 8 10 8 25591;24314;63868;29328;24360;295143;29184;65183 PARP1_9425;NQO1_33055;HSPD1_8849;GPX4_32827;FABP1_33091;ETFDH_8575;CD36_8243;ALDH3A2_8024 43.2046625 42.682900000000004 20.54587075211657 31.428524999999997 29.1755 13.88538392645303 76.3241 67.72395 54.57361768274902 26.9741;87.2765;42.2579;45.9204;33.8478;18.1231;48.1296;43.1079 21.799;60.6992;23.9469;34.2198;26.4736;14.869;37.5433;31.8774 35.2797;197.117;102.383;70.4292;46.9257;23.0103;69.1421;66.3058 10 83516;58954;24516;24471;24464;294515;314322;25661;54232;25303 PPARGC1A_33189;KLF6_8969;JUN_8938;HSPB1_8847;HP_8823;FOXO3_8662;FOS_8657;FN1_8655;CAR3_8196;ABCC2_32541 40.47901000000013 44.320499999999996 27.82854331395274 24.686460000000128 27.4011 18.24681088788436 70.66153000000013 79.37965 40.92666156206302 42.4094;18.9476;16.4324;89.1011;64.9285;13.1992;1.28141E-12;59.5777;53.9626;46.2316 26.2988;11.6941;10.5224;60.3265;41.6103;5.6804;1.28141E-12;31.0499;28.5034;31.1788 81.7305;45.5481;39.929;106.138;136.455;32.7581;1.28142E-12;105.243;77.0288;81.7848 0 Exp 2,8(0.45);Exp 3,1(0.06);Exp 4,1(0.06);Hill,1(0.06);Linear,2(0.12);Poly 2,4(0.23);Power,1(0.06) 1.8948846422070773 35.09634721279144 1.520427942276001 3.910295248031616 0.5626070339853453 1.7939516305923462 30.509504299406277 52.871317922816104 20.12655787697916 35.23930878968765 51.89974341815685 94.45671213739885 CONFLICT 0.4444444444444444 0.5555555555555556 0.0 GO:0071850 7 mitotic cell cycle arrest 4 4 2 2 2 2 2 2 160 2 2383 0.99904 0.022157 0.022157 50.0 25112;114851 gadd45a;cdkn1a GADD45A_8678;CDKN1A_8271 54.584334999999996 54.584334999999996 6.24967 68.35553877576015 54.281499775117474 68.35419711310776 45.970725 45.970725 2.44025 61.56138812154295 45.69798986909823 61.56017981250537 67.2488 67.2488 19.0606 68.14840598634717 66.94688243454911 68.147068389237 0.0 6.24967 0.0 6.24967 102.919;6.24967 89.5012;2.44025 115.437;19.0606 0 2 0 2 25112;114851 GADD45A_8678;CDKN1A_8271 54.584334999999996 54.584334999999996 68.35553877576015 45.970725 45.970725 61.56138812154295 67.2488 67.2488 68.14840598634717 102.919;6.24967 89.5012;2.44025 115.437;19.0606 0 Exp 4,1(0.5);Poly 2,1(0.5) 1.577042408184821 3.156067728996277 1.522104263305664 1.6339634656906128 0.07909640054451568 1.5780338644981384 -40.1516084 149.3202784 -39.349005999999974 131.29045599999998 -27.200071999999977 161.69767199999998 DOWN 0.0 1.0 0.0 GO:0050896 2 response to stimulus 1203 1308 139 138 106 124 95 95 67 1213 1172 0.97745 0.032881 0.061582 7.26 79426;24522;312688;286954;246273;25357;24825;170698;29573;25351;29482;29500;24648;246074;83516;29441;303612;298199;24651;25513;81819;25591;24314;81525;25493;24567;24552;24539;89783;288001;58954;24516;81678;54404;494344;192235;63868;24471;29540;24464;25675;113965;81869;29328;24957;24384;25112;294515;314322;25661;25256;246186;361969;80841;24360;304929;308441;295143;24890;29496;65030;25315;116636;24330;116663;140942;25428;65210;25146;25423;83842;497840;113936;367313;170945;81718;114851;29184;54232;313421;246142;79431;25698;65054;155423;25028;65183;25373;192272;24158;25287;170465;312382;140668;25303 zfp36;zfp354a;usp18;ugt2b1;trib3;thrsp;tf;slco1a2;slc37a4;slc2a2;slc1a2;slc10a2;serpina1;scd;ppargc1a;por;polg2;plin2;pklr;pik3r1;pax8;parp1;nqo1;nfkbib;nfkbia;mt1;me1;lpl;laptm5;kng1;klf6;jun;itpr2;itih4;ier2;hyou1;hspd1;hspb1;hsd17b7;hp;hmgcr;hadh;gstm7;gpx4;glul;gc;gadd45a;foxo3;fos;fn1;fmo1;fgl1;fga;fabp7;fabp1;f5;exosc5;etfdh;esr1;erbb3;ephx2;ephx1;eif4ebp1;egr1;dusp6;ddit4;cyp7a1;cyp2j4;cyp17a1;ctsc;crot;cps1;cpb2;col6a3;chrna2;cdo1;cdkn1a;cd36;car3;c8b;bmf;bhlhe40;ass1;aqp9;anxa7;ampd1;aldh3a2;ahsg;acot2;acadm;acadl;acaa2;abcg2;abcc3;abcc2 ZFP36_10204;ZFP354A_10203;USP18_10138;UGT2B10_33303,UGT2B1_33224;TRIB3_10079;THRSP_33314;TF_10003;SLCO1A2_9886;SLC37A4_9871;SLC2A2_9863;SLC1A2_33059;SLC10A2_9833;SERPINA1_9807;SCD1_9787;PPARGC1A_33189;POR_9531;POLG2_9521;PLIN2_9502;PKLR_9489;PIK3R1_32562;PAX8_9432;PARP1_9425;NQO1_33055;NFKBIB_9308;NFKBIA_9307;MT1A_9255;ME1_9215;LPL_32544;LAPTM5_32639;KNG1L1_34113;KLF6_8969;JUN_8938;ITPR2_8931;ITIH4_32725;IER2_32643;HYOU1_8857;HSPD1_8849;HSPB1_8847;HSD17B7_8834;HP_8823;HMGCR_8810;HADH_8776;GSTM7_8761;GPX4_32827;GLUL_32832;GC_32893;GADD45A_8678;FOXO3_8662;FOS_8657;FN1_8655;FMO1_32787;FGL1_8640;FGA_8632;FABP7_8592;FABP1_33091;F5_33079;EXOSC5_32543;ETFDH_8575;ESR1_33192;ERBB3_8571;EPHX2_33282;EPHX1_8567;EIF4EBP1_8550;EGR1_8533;DUSP6_8506;DDIT4_8450;CYP7A1_8430;CYP2J4_32580;CYP17A1_32365;CTSC_32456;CROT_8384;CPS1_32421;CPB2_8369;COL6A3_33029;CHRNA2_32401;CDO1_8275;CDKN1A_8271;CD36_8243;CAR3_8196;C8B_8181;BMF_8152;BHLHE40_8141;ASS1_33159;AQP9_32709;ANXA7_8051;AMPD1_32743;ALDH3A2_8024;AHSG_8003;ACOT2_7969;ACADM_7957;ACADL_32776;ACAA2_7955;ABCG2_32656;ABCC3_7941;ABCC2_32541 39.71133055789473 33.4878 1.28141E-12 28.539092862401418 42.13886421409927 27.218178960240714 27.534527210526342 24.6273 1.28141E-12 19.846404149259236 29.26892475086283 19.26540595079324 66.65082242105265 46.9856 1.28142E-12 58.52720291656827 68.79523792610243 52.027533928739665 64.5 48.760450000000006 0.348134;0.834827;108.883;47.47345;108.064;32.2053;45.1539;104.197;39.7166;29.7555;13.3235;56.585;15.797;105.46;42.4094;12.4414;63.7758;25.6517;23.0963;18.7324;56.8931;26.9741;87.2765;30.5572;0.520151;12.9315;80.7944;74.2041;38.674;24.3655;18.9476;16.4324;31.8111;57.1163;49.6814;40.1982;42.2579;89.1011;0.977494;64.9285;1.63089;33.3125;42.3152;45.9204;26.4669;42.356;102.919;13.1992;1.28141E-12;59.5777;65.2792;15.4757;28.5803;24.601;33.8478;10.6089;41.9329;18.1231;23.3972;60.9984;38.7293;12.4747;83.9001;0.750017;62.3934;87.5421;5.72128;17.8395;49.6922;56.2386;7.4229;31.9826;25.8316;63.132;49.3913;22.9638;6.24967;48.1296;53.9626;21.3618;94.8767;57.8085;26.8037;27.7316;104.64;60.9045;43.1079;12.402;8.54905;11.7137;33.4878;26.5872;5.21654;37.7175;46.2316 0.118102;0.27095;73.1414;34.82915;83.8836;24.3966;28.132;80.3101;22.6911;23.3399;9.10952;35.2796;13.013;63.7532;26.2988;8.48981;40.9553;20.9252;17.4625;11.6701;45.1162;21.799;60.6992;24.2439;0.160202;8.91033;59.856;49.8682;24.6273;19.538;11.6941;10.5224;24.7342;39.6402;33.4626;29.3844;23.9469;60.3265;0.322682;41.6103;0.663137;25.7336;31.4035;34.2198;21.0456;26.3722;89.5012;5.6804;1.28141E-12;31.0499;39.7882;10.2138;22.529;14.4402;26.4736;2.59129;31.7336;14.869;18.3088;41.6036;29.2097;7.00435;42.4185;0.186019;39.0875;53.2453;0.985273;14.6501;35.6654;38.2681;5.75707;24.4836;20.4374;42.651;41.8524;18.5144;2.44025;37.5433;28.5034;17.2088;73.1342;38.3491;20.9825;21.9372;43.9254;50.0633;31.8774;10.3013;7.19676;8.36151;26.6039;21.3695;2.73368;30.9007;31.1788 1.15962;2.99857;138.144;76.47475;143.428;46.6068;61.5341;128.412;60.0334;40.808;24.6773;116.8;19.9134;422.699;81.7305;79.2355;132.567;33.0375;32.9443;41.5978;81.5688;35.2797;197.117;41.2611;2.88499;23.4636;94.0621;155.425;71.0786;32.1467;45.5481;39.929;44.3296;101.869;89.4404;62.3571;102.383;106.138;5.49472;136.455;7.6286;46.9856;64.5991;70.4292;35.4303;78.7583;115.437;32.7581;1.28142E-12;105.243;82.9415;30.4106;38.8511;35.6155;46.9257;37.5078;62.1373;23.0103;31.9156;113.972;57.2113;23.684;107.32;4.70178;133.304;245.492;22.3625;22.6149;81.6409;102.888;10.316;45.5891;34.8042;121.149;62.472;30.0179;19.0606;69.1421;77.0288;27.9161;109.848;110.58;36.7081;37.4625;108.689;82.6625;66.3058;15.4235;10.4125;18.9642;45.3228;35.0407;11.386;48.9329;81.7848 39 57 38 312688;286954;24825;246074;298199;81819;25591;24314;81525;24539;63868;113965;81869;29328;25256;80841;24360;308441;295143;29496;65030;25315;116636;65210;25146;83842;170945;29184;246142;155423;25028;65183;192272;24158;25287;170465;312382;140668 USP18_10138;UGT2B10_33303,UGT2B1_33224;TF_10003;SCD1_9787;PLIN2_9502;PAX8_9432;PARP1_9425;NQO1_33055;NFKBIB_9308;LPL_32544;HSPD1_8849;HADH_8776;GSTM7_8761;GPX4_32827;FMO1_32787;FABP7_8592;FABP1_33091;EXOSC5_32543;ETFDH_8575;ERBB3_8571;EPHX2_33282;EPHX1_8567;EIF4EBP1_8550;CYP2J4_32580;CYP17A1_32365;CROT_8384;CHRNA2_32401;CD36_8243;BMF_8152;ANXA7_8051;AMPD1_32743;ALDH3A2_8024;ACOT2_7969;ACADM_7957;ACADL_32776;ACAA2_7955;ABCG2_32656;ABCC3_7941 46.09199842105263 42.28655 28.061130299741933 32.02596368421053 31.1521 17.573614753765963 75.35541447368423 62.30465 71.2003913574794 108.883;47.47345;45.1539;105.46;25.6517;56.8931;26.9741;87.2765;30.5572;74.2041;42.2579;33.3125;42.3152;45.9204;65.2792;24.601;33.8478;41.9329;18.1231;60.9984;38.7293;12.4747;83.9001;17.8395;49.6922;7.4229;49.3913;48.1296;94.8767;104.64;60.9045;43.1079;8.54905;11.7137;33.4878;26.5872;5.21654;37.7175 73.1414;34.82915;28.132;63.7532;20.9252;45.1162;21.799;60.6992;24.2439;49.8682;23.9469;25.7336;31.4035;34.2198;39.7882;14.4402;26.4736;31.7336;14.869;41.6036;29.2097;7.00435;42.4185;14.6501;35.6654;5.75707;41.8524;37.5433;73.1342;43.9254;50.0633;31.8774;7.19676;8.36151;26.6039;21.3695;2.73368;30.9007 138.144;76.47475;61.5341;422.699;33.0375;81.5688;35.2797;197.117;41.2611;155.425;102.383;46.9856;64.5991;70.4292;82.9415;35.6155;46.9257;62.1373;23.0103;113.972;57.2113;23.684;107.32;22.6149;81.6409;10.316;62.472;69.1421;109.848;108.689;82.6625;66.3058;10.4125;18.9642;45.3228;35.0407;11.386;48.9329 57 79426;24522;246273;25357;170698;29573;25351;29482;29500;24648;83516;29441;303612;24651;25513;25493;24567;24552;89783;288001;58954;24516;81678;54404;494344;192235;24471;29540;24464;25675;24957;24384;25112;294515;314322;25661;246186;361969;304929;24890;24330;116663;140942;25428;25423;497840;113936;367313;81718;114851;54232;313421;79431;25698;65054;25373;25303 ZFP36_10204;ZFP354A_10203;TRIB3_10079;THRSP_33314;SLCO1A2_9886;SLC37A4_9871;SLC2A2_9863;SLC1A2_33059;SLC10A2_9833;SERPINA1_9807;PPARGC1A_33189;POR_9531;POLG2_9521;PKLR_9489;PIK3R1_32562;NFKBIA_9307;MT1A_9255;ME1_9215;LAPTM5_32639;KNG1L1_34113;KLF6_8969;JUN_8938;ITPR2_8931;ITIH4_32725;IER2_32643;HYOU1_8857;HSPB1_8847;HSD17B7_8834;HP_8823;HMGCR_8810;GLUL_32832;GC_32893;GADD45A_8678;FOXO3_8662;FOS_8657;FN1_8655;FGL1_8640;FGA_8632;F5_33079;ESR1_33192;EGR1_8533;DUSP6_8506;DDIT4_8450;CYP7A1_8430;CTSC_32456;CPS1_32421;CPB2_8369;COL6A3_33029;CDO1_8275;CDKN1A_8271;CAR3_8196;C8B_8181;BHLHE40_8141;ASS1_33159;AQP9_32709;AHSG_8003;ABCC2_32541 35.45755198245617 27.7316 28.29936202003479 24.540236228070192 21.9372 20.83964806870704 60.8477610526316 41.5978 48.1108547799528 0.348134;0.834827;108.064;32.2053;104.197;39.7166;29.7555;13.3235;56.585;15.797;42.4094;12.4414;63.7758;23.0963;18.7324;0.520151;12.9315;80.7944;38.674;24.3655;18.9476;16.4324;31.8111;57.1163;49.6814;40.1982;89.1011;0.977494;64.9285;1.63089;26.4669;42.356;102.919;13.1992;1.28141E-12;59.5777;15.4757;28.5803;10.6089;23.3972;0.750017;62.3934;87.5421;5.72128;56.2386;31.9826;25.8316;63.132;22.9638;6.24967;53.9626;21.3618;57.8085;26.8037;27.7316;12.402;46.2316 0.118102;0.27095;83.8836;24.3966;80.3101;22.6911;23.3399;9.10952;35.2796;13.013;26.2988;8.48981;40.9553;17.4625;11.6701;0.160202;8.91033;59.856;24.6273;19.538;11.6941;10.5224;24.7342;39.6402;33.4626;29.3844;60.3265;0.322682;41.6103;0.663137;21.0456;26.3722;89.5012;5.6804;1.28141E-12;31.0499;10.2138;22.529;2.59129;18.3088;0.186019;39.0875;53.2453;0.985273;38.2681;24.4836;20.4374;42.651;18.5144;2.44025;28.5034;17.2088;38.3491;20.9825;21.9372;10.3013;31.1788 1.15962;2.99857;143.428;46.6068;128.412;60.0334;40.808;24.6773;116.8;19.9134;81.7305;79.2355;132.567;32.9443;41.5978;2.88499;23.4636;94.0621;71.0786;32.1467;45.5481;39.929;44.3296;101.869;89.4404;62.3571;106.138;5.49472;136.455;7.6286;35.4303;78.7583;115.437;32.7581;1.28142E-12;105.243;30.4106;38.8511;37.5078;31.9156;4.70178;133.304;245.492;22.3625;102.888;45.5891;34.8042;121.149;30.0179;19.0606;77.0288;27.9161;110.58;36.7081;37.4625;15.4235;81.7848 0 Exp 2,38(0.4);Exp 3,4(0.05);Exp 4,6(0.07);Hill,8(0.09);Linear,19(0.2);Poly 2,19(0.2);Power,2(0.03) 2.001223570139572 208.21674811840057 1.5074360370635986 11.836054801940918 1.2811275829905227 1.7718074917793274 33.97235423076026 45.45030688502919 23.543578929847218 31.525475491205423 54.881484353755766 78.42016048834948 DOWN 0.4 0.6 0.0 GO:0033499 8 galactose catabolic process via UDP-galactose 2 2 1 1 1 1 1 1 161 1 2384 0.99598 0.12319 0.12319 50.0 114860 gale GALE_8680 71.148 71.148 71.148 71.148 43.2839 43.2839 43.2839 43.2839 88.9033 88.9033 88.9033 88.9033 0.0 71.148 0.0 71.148 71.148 43.2839 88.9033 0 1 0 1 114860 GALE_8680 71.148 71.148 43.2839 43.2839 88.9033 88.9033 71.148 43.2839 88.9033 0 Poly 2,1(1) 1.8488826751708984 1.8488826751708984 1.8488826751708984 1.8488826751708984 0.0 1.8488826751708984 71.148 71.148 43.2839 43.2839 88.9033 88.9033 DOWN 0.0 1.0 0.0 GO:0046326 8 positive regulation of glucose import 16 17 2 2 2 2 2 2 160 15 2370 0.91096 0.295 0.295 11.76 29482;29496 slc1a2;erbb3 SLC1A2_33059;ERBB3_8571 37.16095 37.16095 13.3235 33.71124508239053 38.93800290347894 33.617439089875276 25.35656 25.35656 9.10952 22.97678431641817 26.56775707036359 22.91284837894855 69.32464999999999 69.32464999999999 24.6773 63.14088789401842 72.65305563693434 62.96519003288283 0.0 13.3235 0.5 37.16095 13.3235;60.9984 9.10952;41.6036 24.6773;113.972 1 1 1 29496 ERBB3_8571 60.9984 60.9984 41.6036 41.6036 113.972 113.972 60.9984 41.6036 113.972 1 29482 SLC1A2_33059 13.3235 13.3235 9.10952 9.10952 24.6773 24.6773 13.3235 9.10952 24.6773 0 Linear,1(0.5);Poly 2,1(0.5) 1.6107817465480896 3.2216196060180664 1.6013026237487793 1.620316982269287 0.013445181849763283 1.6108098030090332 -9.560451999999998 83.882352 -6.4876383999999945 57.20075839999999 -18.184155999999987 156.83345599999996 CONFLICT 0.5 0.5 0.0 GO:0071363 6 cellular response to growth factor stimulus 136 141 10 10 10 8 8 8 154 133 2252 0.45209 0.68661 0.8599 5.67 79426;83516;25591;24471;294515;25661;24330;497840 zfp36;ppargc1a;parp1;hspb1;foxo3;fn1;egr1;cps1 ZFP36_10204;PPARGC1A_33189;PARP1_9425;HSPB1_8847;FOXO3_8662;FN1_8655;EGR1_8533;CPS1_32421 33.042781375000004 29.47835 0.348134 30.42051407446689 40.311590986294554 30.187325902308725 21.242790125000003 23.1413 0.118102 19.971119435726553 25.7735003987139 19.291581905275294 51.57497500000001 40.4344 1.15962 41.68072900628537 61.77997544234184 42.22429489573792 6.5 74.3394 0.348134;42.4094;26.9741;89.1011;13.1992;59.5777;0.750017;31.9826 0.118102;26.2988;21.799;60.3265;5.6804;31.0499;0.186019;24.4836 1.15962;81.7305;35.2797;106.138;32.7581;105.243;4.70178;45.5891 1 7 1 25591 PARP1_9425 26.9741 26.9741 21.799 21.799 35.2797 35.2797 26.9741 21.799 35.2797 7 79426;83516;24471;294515;25661;24330;497840 ZFP36_10204;PPARGC1A_33189;HSPB1_8847;FOXO3_8662;FN1_8655;EGR1_8533;CPS1_32421 33.909735857142856 31.9826 32.75098871722258 21.163331571428575 24.4836 21.569908497546557 53.90287142857143 45.5891 44.45505688083019 0.348134;42.4094;89.1011;13.1992;59.5777;0.750017;31.9826 0.118102;26.2988;60.3265;5.6804;31.0499;0.186019;24.4836 1.15962;81.7305;106.138;32.7581;105.243;4.70178;45.5891 0 Exp 2,3(0.38);Exp 4,1(0.13);Hill,2(0.25);Poly 2,1(0.13);Power,1(0.13) 2.027049702179112 17.01412284374237 1.6973176002502441 4.21828556060791 0.8503791017694079 1.8175725936889648 11.962440621548371 54.12312212845163 7.403510423729074 35.08206982627093 22.691703397359642 80.45824660264034 DOWN 0.125 0.875 0.0 GO:0001775 3 cell activation 161 172 8 7 5 6 5 5 157 167 2218 0.030258 0.98871 0.052373 2.91 25513;24516;63868;25661;24330 pik3r1;jun;hspd1;fn1;egr1 PIK3R1_32562;JUN_8938;HSPD1_8849;FN1_8655;EGR1_8533 27.5500834 18.7324 0.750017 23.246967963508222 33.38558282950809 25.974474215930954 15.475063799999997 11.6701 0.186019 12.115166635131448 18.2096108732872 13.480450806643134 58.770916 41.5978 4.70178 43.68945422414063 67.79927996231842 46.92973776279282 18.7324;16.4324;42.2579;59.5777;0.750017 11.6701;10.5224;23.9469;31.0499;0.186019 41.5978;39.929;102.383;105.243;4.70178 1 4 1 63868 HSPD1_8849 42.2579 42.2579 23.9469 23.9469 102.383 102.383 42.2579 23.9469 102.383 4 25513;24516;25661;24330 PIK3R1_32562;JUN_8938;FN1_8655;EGR1_8533 23.873129249999998 17.5824 25.10834019179993 13.35710475 11.09625 12.876257733240028 47.867895 40.763400000000004 41.863095534071135 18.7324;16.4324;59.5777;0.750017 11.6701;10.5224;31.0499;0.186019 41.5978;39.929;105.243;4.70178 0 Exp 3,1(0.2);Hill,1(0.2);Poly 2,2(0.4);Power,1(0.2) 2.236549265695057 11.901455640792847 1.6735800504684448 4.21828556060791 1.0508166635139806 1.9785058498382568 7.1732175502316196 47.926949249768384 4.855652027282611 26.094475572717393 20.47542089834284 97.06641110165717 DOWN 0.2 0.8 0.0 GO:0001934 9 positive regulation of protein phosphorylation 270 289 18 18 15 16 13 13 149 276 2109 0.1021 0.9395 0.20004 4.5 24825;25513;24516;25675;29455;299626;25112;361969;24890;29496;24330;114851;29184 tf;pik3r1;jun;hmgcr;gdf15;gadd45b;gadd45a;fga;esr1;erbb3;egr1;cdkn1a;cd36 TF_10003;PIK3R1_32562;JUN_8938;HMGCR_8810;GDF15_33113;GADD45B_8679;GADD45A_8678;FGA_8632;ESR1_33192;ERBB3_8571;EGR1_8533;CDKN1A_8271;CD36_8243 43.42229053846154 28.5803 0.750017 39.32211001279044 46.84651601244926 38.35758083907526 30.858592769230768 22.529 0.186019 29.891663786605775 35.447244406940825 31.96755971944759 59.91197538461539 41.5978 4.70178 43.0892103526611 64.43843944726937 42.80503233664999 45.1539;18.7324;16.4324;1.63089;105.149;106.367;102.919;28.5803;23.3972;60.9984;0.750017;6.24967;48.1296 28.132;11.6701;10.5224;0.663137;85.3487;52.7132;89.5012;22.529;18.3088;41.6036;0.186019;2.44025;37.5433 61.5341;41.5978;39.929;7.6286;125.652;109.434;115.437;38.8511;31.9156;113.972;4.70178;19.0606;69.1421 4 9 4 24825;299626;29496;29184 TF_10003;GADD45B_8679;ERBB3_8571;CD36_8243 65.162225 54.564 28.317334532799844 39.998025 39.57345 10.183021334350325 88.52055 89.28805 27.011981946351142 45.1539;106.367;60.9984;48.1296 28.132;52.7132;41.6036;37.5433 61.5341;109.434;113.972;69.1421 9 25513;24516;25675;29455;25112;361969;24890;24330;114851 PIK3R1_32562;JUN_8938;HMGCR_8810;GDF15_33113;GADD45A_8678;FGA_8632;ESR1_33192;EGR1_8533;CDKN1A_8271 33.76009744444444 18.7324 40.95486073887603 26.796622888888887 11.6701 35.22861712604491 47.197053333333336 38.8511 43.821218788323314 18.7324;16.4324;1.63089;105.149;102.919;28.5803;23.3972;0.750017;6.24967 11.6701;10.5224;0.663137;85.3487;89.5012;22.529;18.3088;0.186019;2.44025 41.5978;39.929;7.6286;125.652;115.437;38.8511;31.9156;4.70178;19.0606 0 Exp 2,2(0.16);Exp 4,2(0.16);Hill,1(0.08);Linear,2(0.16);Poly 2,5(0.39);Power,1(0.08) 1.9169046906434974 26.12650752067566 1.522104263305664 4.21828556060791 0.754332034078356 1.6735800504684448 22.046548041178333 64.79803303574474 14.60929923666055 47.107886301801 36.48841381556032 83.33553695367044 DOWN 0.3076923076923077 0.6923076923076923 0.0 GO:0006790 4 sulfur compound metabolic process 86 101 24 24 18 22 17 17 145 84 2301 0.99996 1.4582E-4 1.4582E-4 16.83 360268;293656;298490;81819;294103;100359982;81869;57298;29328;497840;81718;192272;170570;50559;170465;25303;296925 sult1e1;rgd1307603;ppcs;pax8;papss2;mpc2;gstm7;gstm3l;gpx4;cps1;cdo1;acot2;acot12;acot1;acaa2;abcc2;aass SULT1E1_32446;RGD1307603_9684;PPCS_9540;PAX8_9432;PAPSS2_33237;MPC2_33219;GSTM7_8761;GSTM3_8760;GPX4_32827;CPS1_32421;CDO1_8275;ACOT2_7969;ACOT12_32718;ACOT1_7968;ACAA2_7955;ABCC2_32541;AASS_7936 37.064426470588224 34.4443 8.54905 15.33120174593018 37.138044897209134 14.052501302845872 28.149303529411764 26.1766 7.19676 10.622841355280695 28.640368644309177 9.823484113750512 56.08740000000001 50.9085 10.4125 30.414032343167676 54.69642553003331 27.7747385633945 4.5 28.903350000000003 9.5 38.5262 50.1846;34.7372;20.3353;56.8931;34.4443;46.8463;42.3152;73.0961;45.9204;31.9826;22.9638;8.54905;30.3423;31.2018;26.5872;46.2316;27.4644 36.5009;26.1766;16.7643;45.1162;25.719;35.8494;31.4035;51.4219;34.2198;24.4836;18.5144;7.19676;24.0157;26.858;21.3695;31.1788;21.7498 80.9788;50.9085;25.6711;81.5688;51.1014;69.127;64.5991;140.853;70.4292;45.5891;30.0179;10.4125;41.1025;37.2719;35.0407;81.7848;37.0295 12 5 12 360268;298490;81819;100359982;81869;57298;29328;192272;170570;50559;170465;296925 SULT1E1_32446;PPCS_9540;PAX8_9432;MPC2_33219;GSTM7_8761;GSTM3_8760;GPX4_32827;ACOT2_7969;ACOT12_32718;ACOT1_7968;ACAA2_7955;AASS_7936 38.31131249999999 36.7585 17.635461462428044 29.372146666666666 29.13075 12.293115070786088 57.84034166666667 52.85080000000001 34.72158021512527 50.1846;20.3353;56.8931;46.8463;42.3152;73.0961;45.9204;8.54905;30.3423;31.2018;26.5872;27.4644 36.5009;16.7643;45.1162;35.8494;31.4035;51.4219;34.2198;7.19676;24.0157;26.858;21.3695;21.7498 80.9788;25.6711;81.5688;69.127;64.5991;140.853;70.4292;10.4125;41.1025;37.2719;35.0407;37.0295 5 293656;294103;497840;81718;25303 RGD1307603_9684;PAPSS2_33237;CPS1_32421;CDO1_8275;ABCC2_32541 34.0719 34.4443 8.30955278640193 25.21448 25.719 4.532620267792139 51.880340000000004 50.9085 18.79743288252413 34.7372;34.4443;31.9826;22.9638;46.2316 26.1766;25.719;24.4836;18.5144;31.1788 50.9085;51.1014;45.5891;30.0179;81.7848 0 Exp 2,13(0.77);Linear,4(0.24) 2.9212784812270756 385.3832700252533 1.547789216041565 344.14306640625 82.87689911287293 1.9082608222961426 29.77643577849395 44.35241716268253 23.09952529259273 33.19908176623078 41.62948676531818 70.54531323468183 UP 0.7058823529411765 0.29411764705882354 0.0 GO:1901607 7 alpha-amino acid biosynthetic process 18 19 4 4 3 4 3 3 159 16 2369 0.97118 0.11579 0.11579 15.79 24957;25698;296925 glul;ass1;aass GLUL_32832;ASS1_33159;AASS_7936 26.911666666666665 26.8037 26.4669 0.5074388271832864 26.965988776969475 0.5061204972160486 21.2593 21.0456 20.9825 0.42595550237088 21.292505005285086 0.44137597242949517 36.3893 36.7081 35.4303 0.8459227151460761 36.489005813592 0.8015364727160028 0.0 26.4669 0.5 26.6353 26.4669;26.8037;27.4644 21.0456;20.9825;21.7498 35.4303;36.7081;37.0295 1 2 1 296925 AASS_7936 27.4644 27.4644 21.7498 21.7498 37.0295 37.0295 27.4644 21.7498 37.0295 2 24957;25698 GLUL_32832;ASS1_33159 26.6353 26.6353 0.23815356390321538 21.01405 21.01405 0.0446184378940473 36.0692 36.0692 0.90354104500021 26.4669;26.8037 21.0456;20.9825 35.4303;36.7081 0 Exp 2,1(0.34);Linear,2(0.67) 2.046611994251173 6.172507047653198 1.8814297914505005 2.3622660636901855 0.26499422736341793 1.9288111925125122 26.337445577462248 27.48588775587109 20.777285973045043 21.741314026954957 35.43204833368579 37.346551666314205 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0000027 8 ribosomal large subunit assembly 6 6 2 2 2 2 2 2 160 4 2381 0.99562 0.050905 0.050905 33.33 297784;298699 rrs1;ppan RRS1_9755;PPAN_9534 59.03945 59.03945 57.6889 1.9099661266626147 58.67001808391488 1.8371202257215957 42.23745 42.23745 41.3659 1.232557830286122 41.9990446196261 1.1855482083059548 101.55805 101.55805 98.1741 4.78562798439221 100.63239813043853 4.603104652052708 0.0 57.6889 0.0 57.6889 60.39;57.6889 43.109;41.3659 104.942;98.1741 2 0 2 297784;298699 RRS1_9755;PPAN_9534 59.03945 59.03945 1.9099661266626147 42.23745 42.23745 1.232557830286122 101.55805 101.55805 4.78562798439221 60.39;57.6889 43.109;41.3659 104.942;98.1741 0 0 Exp 2,2(1) 2.011718292495221 4.055438756942749 1.773484468460083 2.281954288482666 0.3595424577666718 2.0277193784713745 56.392372 61.686528 40.529212 43.945688000000004 94.925508 108.190592 UP 1.0 0.0 0.0 GO:0007632 5 visual behavior 13 14 2 2 2 2 2 2 160 12 2373 0.94527 0.22236 0.22236 14.29 29482;25675 slc1a2;hmgcr SLC1A2_33059;HMGCR_8810 7.477195 7.477195 1.63089 8.267923820769635 11.276884290377739 6.283572781406085 4.8863285 4.8863285 0.663137 5.9724946957987735 7.631107555106482 4.5390603398326865 16.15295 16.15295 7.6286 12.055251380415088 21.693181206280116 9.161919133397754 0.0 1.63089 0.5 7.477195 13.3235;1.63089 9.10952;0.663137 24.6773;7.6286 0 2 0 2 29482;25675 SLC1A2_33059;HMGCR_8810 7.477195 7.477195 8.267923820769635 4.8863285 4.8863285 5.9724946957987735 16.15295 16.15295 12.055251380415088 13.3235;1.63089 9.10952;0.663137 24.6773;7.6286 0 Exp 4,1(0.5);Poly 2,1(0.5) 1.7554117504285276 3.5220870971679688 1.620316982269287 1.9017701148986816 0.1990174186684416 1.7610435485839844 -3.981562799999997 18.935952799999995 -3.391126839999999 13.16378384 -0.5547760000000004 32.860676 DOWN 0.0 1.0 0.0 GO:0015909 8 long-chain fatty acid transport 19 21 7 7 5 7 5 5 157 16 2369 0.99853 0.0086526 0.0086526 23.81 65192;298199;24360;83842;29184 slc27a2;plin2;fabp1;crot;cd36 SLC27A2_9860;PLIN2_9502;FABP1_33091;CROT_8384;CD36_8243 24.534778 25.6517 7.4229 17.489694593714894 26.52154510794967 19.86138993873231 19.239666 20.9252 5.49916 13.79108175255589 20.589126996711467 15.688179658050952 34.562760000000004 33.0375 10.316 24.428388901603807 38.39884498141264 27.46513284612124 0.5 7.5223949999999995 1.5 16.636795 7.62189;25.6517;33.8478;7.4229;48.1296 5.49916;20.9252;26.4736;5.75707;37.5433 13.3925;33.0375;46.9257;10.316;69.1421 5 0 5 65192;298199;24360;83842;29184 SLC27A2_9860;PLIN2_9502;FABP1_33091;CROT_8384;CD36_8243 24.534778 25.6517 17.489694593714894 19.239666 20.9252 13.79108175255589 34.562760000000004 33.0375 24.428388901603807 7.62189;25.6517;33.8478;7.4229;48.1296 5.49916;20.9252;26.4736;5.75707;37.5433 13.3925;33.0375;46.9257;10.316;69.1421 0 0 Exp 2,3(0.6);Hill,1(0.2);Poly 2,1(0.2) 2.712279809977239 14.943657040596008 1.8753424882888794 5.963563919067383 1.686952030260999 2.2497289180755615 9.204384761235234 39.86517123876477 7.151249857467015 31.328082142532985 13.150333039403296 55.975186960596716 UP 1.0 0.0 0.0 GO:1903038 8 negative regulation of leukocyte cell-cell adhesion 40 41 2 2 2 2 2 2 160 39 2346 0.51033 0.74666 1.0 4.88 246186;25698 fgl1;ass1 FGL1_8640;ASS1_33159 21.139699999999998 21.139699999999998 15.4757 8.010105617281218 19.572504928131416 7.697375605582823 15.59815 15.59815 10.2138 7.614620794563583 14.108332417864478 7.317331275056482 33.55935 33.55935 30.4106 4.453004954522223 32.68810962525667 4.279151030734284 15.4757;26.8037 10.2138;20.9825 30.4106;36.7081 0 2 0 2 246186;25698 FGL1_8640;ASS1_33159 21.139699999999998 21.139699999999998 8.010105617281218 15.59815 15.59815 7.614620794563583 33.55935 33.55935 4.453004954522223 15.4757;26.8037 10.2138;20.9825 30.4106;36.7081 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.6862520058188453 3.3927515745162964 1.511321783065796 1.8814297914505005 0.2617058825002722 1.6963757872581482 10.03826 32.241139999999994 5.044824 26.151476000000002 27.3878 39.730900000000005 DOWN 0.0 1.0 0.0 GO:2000379 7 positive regulation of reactive oxygen species metabolic process 59 62 9 9 8 9 8 8 154 54 2331 0.98507 0.040168 0.056319 12.9 293615;25106;25112;294515;24890;114851;29184;25698 sirt3;rgn;gadd45a;foxo3;esr1;cdkn1a;cd36;ass1 SIRT3_9828;RGN_9699;GADD45A_8678;FOXO3_8662;ESR1_33192;CDKN1A_8271;CD36_8243;ASS1_33159 37.56490625 25.100450000000002 2.38018 36.058827599970954 43.898300696984776 39.331474777176176 29.2239675 19.645650000000003 0.56209 31.29570069998696 35.04917782441178 34.485462023228976 50.45692125 34.7331 8.82917 37.195337355832436 57.22271813091192 40.55141816325003 2.5 18.2982 5.5 62.78515 2.38018;77.4407;102.919;13.1992;23.3972;6.24967;48.1296;26.8037 0.56209;58.7732;89.5012;5.6804;18.3088;2.44025;37.5433;20.9825 8.82917;89.8047;115.437;32.7581;31.9156;19.0606;69.1421;36.7081 3 5 3 293615;25106;29184 SIRT3_9828;RGN_9699;CD36_8243 42.65016000000001 48.1296 37.82907099973247 32.29286333333334 37.5433 29.458592053101135 55.92532333333333 69.1421 42.07459451720996 2.38018;77.4407;48.1296 0.56209;58.7732;37.5433 8.82917;89.8047;69.1421 5 25112;294515;24890;114851;25698 GADD45A_8678;FOXO3_8662;ESR1_33192;CDKN1A_8271;ASS1_33159 34.51375399999999 23.3972 39.100732225932546 27.38263 18.3088 35.61994490720052 47.17588 32.7581 38.73103541434182 102.919;13.1992;23.3972;6.24967;26.8037 89.5012;5.6804;18.3088;2.44025;20.9825 115.437;32.7581;31.9156;19.0606;36.7081 0 Exp 2,3(0.38);Exp 4,2(0.25);Hill,1(0.13);Poly 2,2(0.25) 1.8834873507690588 15.373994588851929 1.5209722518920898 2.6703107357025146 0.42691268983090375 1.8006581664085388 12.57741356277543 62.55239893722458 7.537153356793549 50.91078164320645 24.681867482626178 76.23197501737381 DOWN 0.375 0.625 0.0 GO:2000778 7 positive regulation of interleukin-6 secretion 15 16 2 2 2 2 2 2 160 14 2371 0.92323 0.27077 0.27077 12.5 24539;63868 lpl;hspd1 LPL_32544;HSPD1_8849 58.230999999999995 58.230999999999995 42.2579 22.589374653141707 61.163573811270425 22.205401795574456 36.90755 36.90755 23.9469 18.32912700717086 39.28705446482161 18.017569587732638 128.904 128.904 102.383 37.506357887696986 133.77311057019008 36.868827029219624 0.0 42.2579 0.5 58.230999999999995 74.2041;42.2579 49.8682;23.9469 155.425;102.383 2 0 2 24539;63868 LPL_32544;HSPD1_8849 58.230999999999995 58.230999999999995 22.589374653141707 36.90755 36.90755 18.32912700717086 128.904 128.904 37.506357887696986 74.2041;42.2579 49.8682;23.9469 155.425;102.383 0 0 Exp 2,1(0.5);Exp 3,1(0.5) 1.8739087143590512 3.8112497329711914 1.559399127960205 2.2518506050109863 0.4896371350652484 1.9056248664855957 26.923724 89.538276 11.504676 62.310424 76.92283999999998 180.88516 UP 1.0 0.0 0.0 GO:0010035 4 response to inorganic substance 271 293 31 31 26 28 23 23 139 270 2115 0.88981 0.16223 0.25371 7.85 24825;24648;83516;24651;25513;25591;24314;24567;58954;24516;63868;24471;24464;314322;25661;361969;24360;497840;25698;65054;155423;24158;312382 tf;serpina1;ppargc1a;pklr;pik3r1;parp1;nqo1;mt1;klf6;jun;hspd1;hspb1;hp;fos;fn1;fga;fabp1;cps1;ass1;aqp9;anxa7;acadm;abcg2 TF_10003;SERPINA1_9807;PPARGC1A_33189;PKLR_9489;PIK3R1_32562;PARP1_9425;NQO1_33055;MT1A_9255;KLF6_8969;JUN_8938;HSPD1_8849;HSPB1_8847;HP_8823;FOS_8657;FN1_8655;FGA_8632;FABP1_33091;CPS1_32421;ASS1_33159;AQP9_32709;ANXA7_8051;ACADM_7957;ABCG2_32656 36.266632173913095 27.7316 1.28141E-12 27.747206683932994 39.25234039198987 26.49294393655093 23.415718260869617 21.9372 1.28141E-12 15.97384024970155 24.925880894881672 14.679732971124423 59.732704347826136 41.5978 1.28142E-12 46.81726241870883 62.63752599977856 40.73135162769869 13.5 32.9152 45.1539;15.797;42.4094;23.0963;18.7324;26.9741;87.2765;12.9315;18.9476;16.4324;42.2579;89.1011;64.9285;1.28141E-12;59.5777;28.5803;33.8478;31.9826;26.8037;27.7316;104.64;11.7137;5.21654 28.132;13.013;26.2988;17.4625;11.6701;21.799;60.6992;8.91033;11.6941;10.5224;23.9469;60.3265;41.6103;1.28141E-12;31.0499;22.529;26.4736;24.4836;20.9825;21.9372;43.9254;8.36151;2.73368 61.5341;19.9134;81.7305;32.9443;41.5978;35.2797;197.117;23.4636;45.5481;39.929;102.383;106.138;136.455;1.28142E-12;105.243;38.8511;46.9257;45.5891;36.7081;37.4625;108.689;18.9642;11.386 8 15 8 24825;25591;24314;63868;24360;155423;24158;312382 TF_10003;PARP1_9425;NQO1_33055;HSPD1_8849;FABP1_33091;ANXA7_8051;ACADM_7957;ABCG2_32656 44.635055 38.05285 34.82756597860255 27.00891125 25.210250000000002 18.502056055281635 72.7848375 54.2299 61.51891048730901 45.1539;26.9741;87.2765;42.2579;33.8478;104.64;11.7137;5.21654 28.132;21.799;60.6992;23.9469;26.4736;43.9254;8.36151;2.73368 61.5341;35.2797;197.117;102.383;46.9257;108.689;18.9642;11.386 15 24648;83516;24651;25513;24567;58954;24516;24471;24464;314322;25661;361969;497840;25698;65054 SERPINA1_9807;PPARGC1A_33189;PKLR_9489;PIK3R1_32562;MT1A_9255;KLF6_8969;JUN_8938;HSPB1_8847;HP_8823;FOS_8657;FN1_8655;FGA_8632;CPS1_32421;ASS1_33159;AQP9_32709 31.803473333333418 26.8037 23.28121293702784 21.499348666666755 20.9825 14.781602150780246 52.77156666666676 39.929 37.45384959212489 15.797;42.4094;23.0963;18.7324;12.9315;18.9476;16.4324;89.1011;64.9285;1.28141E-12;59.5777;28.5803;31.9826;26.8037;27.7316 13.013;26.2988;17.4625;11.6701;8.91033;11.6941;10.5224;60.3265;41.6103;1.28141E-12;31.0499;22.529;24.4836;20.9825;21.9372 19.9134;81.7305;32.9443;41.5978;23.4636;45.5481;39.929;106.138;136.455;1.28142E-12;105.243;38.8511;45.5891;36.7081;37.4625 0 Exp 2,9(0.4);Exp 3,2(0.09);Exp 4,1(0.05);Hill,1(0.05);Linear,2(0.09);Poly 2,7(0.31);Power,1(0.05) 1.8008251324305047 41.82475924491882 1.5074360370635986 2.6967689990997314 0.275939671846184 1.7792335748672485 24.92667478880827 47.60658955901795 16.887397418650266 29.944039103088976 40.59903922747912 78.86636946817316 DOWN 0.34782608695652173 0.6521739130434783 0.0 GO:0031323 5 regulation of cellular metabolic process 979 1054 87 87 72 76 64 64 98 990 1395 0.33909 0.7192 0.68035 6.07 79426;24522;246273;25357;24825;293615;79224;24794;24648;25106;252922;192280;83516;29441;303612;363465;25513;81819;25591;81525;25493;299282;288001;58954;24516;54404;50693;306251;494344;63868;24471;24464;25675;290556;29455;299626;25112;294515;314322;25661;246186;361969;83928;24360;24890;29496;116636;24330;116663;140942;25428;25146;25423;113936;25695;114851;29184;246142;79431;25698;25377;25373;24158;25287 zfp36;zfp354a;trib3;thrsp;tf;sirt3;serpind1;serpina3c;serpina1;rgn;pzp;ppp1r3b;ppargc1a;por;polg2;pir;pik3r1;pax8;parp1;nfkbib;nfkbia;loc299282;kng1;klf6;jun;itih4;itih3;itih1;ier2;hspd1;hspb1;hp;hmgcr;gnl3;gdf15;gadd45b;gadd45a;foxo3;fos;fn1;fgl1;fga;fetub;fabp1;esr1;erbb3;eif4ebp1;egr1;dusp6;ddit4;cyp7a1;cyp17a1;ctsc;cpb2;cebpd;cdkn1a;cd36;bmf;bhlhe40;ass1;ambp;ahsg;acadm;acadl ZFP36_10204;ZFP354A_10203;TRIB3_10079;THRSP_33314;TF_10003;SIRT3_9828;SERPIND1_9812;SERPINA3C_32925;SERPINA1_9807;RGN_9699;PZP_9633;PPP1R3B_9545;PPARGC1A_33189;POR_9531;POLG2_9521;PIR_9487;PIK3R1_32562;PAX8_9432;PARP1_9425;NFKBIB_9308;NFKBIA_9307;LOC299282_9119;KNG1L1_34113;KLF6_8969;JUN_8938;ITIH4_32725;ITIH3_32422;ITIH1_33132;IER2_32643;HSPD1_8849;HSPB1_8847;HP_8823;HMGCR_8810;GNL3_8735;GDF15_33113;GADD45B_8679;GADD45A_8678;FOXO3_8662;FOS_8657;FN1_8655;FGL1_8640;FGA_8632;FETUB_33027;FABP1_33091;ESR1_33192;ERBB3_8571;EIF4EBP1_8550;EGR1_8533;DUSP6_8506;DDIT4_8450;CYP7A1_8430;CYP17A1_32365;CTSC_32456;CPB2_8369;CEBPD_8283;CDKN1A_8271;CD36_8243;BMF_8152;BHLHE40_8141;ASS1_33159;AMBP_33085;AHSG_8003;ACADM_7957;ACADL_32776 40.60344195312502 33.00165 1.28141E-12 31.03745997682864 44.464030775518836 30.573027440722267 27.842074643750014 24.32025 1.28141E-12 21.626257204329693 30.791255116454188 22.303838631335193 66.03823000000003 47.74615 1.28142E-12 51.54494405878758 68.90173571967732 43.422941913095116 51.5 64.35215 0.348134;0.834827;108.064;32.2053;45.1539;2.38018;28.261;29.766;15.797;77.4407;34.1871;36.1411;42.4094;12.4414;63.7758;50.0307;18.7324;56.8931;26.9741;30.5572;0.520151;45.2017;24.3655;18.9476;16.4324;57.1163;27.1247;98.1741;49.6814;42.2579;89.1011;64.9285;1.63089;87.6357;105.149;106.367;102.919;13.1992;1.28141E-12;59.5777;15.4757;28.5803;32.5155;33.8478;23.3972;60.9984;83.9001;0.750017;62.3934;87.5421;5.72128;49.6922;56.2386;25.8316;0.306936;6.24967;48.1296;94.8767;57.8085;26.8037;17.2343;12.402;11.7137;33.4878 0.118102;0.27095;83.8836;24.3966;28.132;0.56209;22.307;23.347;13.013;58.7732;26.3085;27.0588;26.2988;8.48981;40.9553;38.7717;11.6701;45.1162;21.799;24.2439;0.160202;30.7472;19.538;11.6941;10.5224;39.6402;21.5108;42.9071;33.4626;23.9469;60.3265;41.6103;0.663137;54.41;85.3487;52.7132;89.5012;5.6804;1.28141E-12;31.0499;10.2138;22.529;19.6094;26.4736;18.3088;41.6036;42.4185;0.186019;39.0875;53.2453;0.985273;35.6654;38.2681;20.4374;0.0732342;2.44025;37.5433;73.1342;38.3491;20.9825;14.1233;10.3013;8.36151;26.6039 1.15962;2.99857;143.428;46.6068;61.5341;8.82917;38.3264;40.8256;19.9134;89.8047;48.5666;53.6244;81.7305;79.2355;132.567;73.0083;41.5978;81.5688;35.2797;41.2611;2.88499;78.6415;32.1467;45.5481;39.929;101.869;36.4819;104.278;89.4404;102.383;106.138;136.455;7.6286;238.963;125.652;109.434;115.437;32.7581;1.28142E-12;105.243;30.4106;38.8511;49.9875;46.9257;31.9156;113.972;107.32;4.70178;133.304;245.492;22.3625;81.6409;102.888;34.8042;1.73689;19.0606;69.1421;109.848;110.58;36.7081;21.9073;15.4235;18.9642;45.3228 18 46 18 24825;293615;25106;363465;81819;25591;81525;63868;290556;299626;24360;29496;116636;25146;29184;246142;24158;25287 TF_10003;SIRT3_9828;RGN_9699;PIR_9487;PAX8_9432;PARP1_9425;NFKBIB_9308;HSPD1_8849;GNL3_8735;GADD45B_8679;FABP1_33091;ERBB3_8571;EIF4EBP1_8550;CYP17A1_32365;CD36_8243;BMF_8152;ACADM_7957;ACADL_32776 52.35204333333334 48.9109 28.53375817998806 35.570677777777775 36.60435 17.862571837552522 79.73342055555555 77.28855 51.233853549366735 45.1539;2.38018;77.4407;50.0307;56.8931;26.9741;30.5572;42.2579;87.6357;106.367;33.8478;60.9984;83.9001;49.6922;48.1296;94.8767;11.7137;33.4878 28.132;0.56209;58.7732;38.7717;45.1162;21.799;24.2439;23.9469;54.41;52.7132;26.4736;41.6036;42.4185;35.6654;37.5433;73.1342;8.36151;26.6039 61.5341;8.82917;89.8047;73.0083;81.5688;35.2797;41.2611;102.383;238.963;109.434;46.9257;113.972;107.32;81.6409;69.1421;109.848;18.9642;45.3228 46 79426;24522;246273;25357;79224;24794;24648;252922;192280;83516;29441;303612;25513;25493;299282;288001;58954;24516;54404;50693;306251;494344;24471;24464;25675;29455;25112;294515;314322;25661;246186;361969;83928;24890;24330;116663;140942;25428;25423;113936;25695;114851;79431;25698;25377;25373 ZFP36_10204;ZFP354A_10203;TRIB3_10079;THRSP_33314;SERPIND1_9812;SERPINA3C_32925;SERPINA1_9807;PZP_9633;PPP1R3B_9545;PPARGC1A_33189;POR_9531;POLG2_9521;PIK3R1_32562;NFKBIA_9307;LOC299282_9119;KNG1L1_34113;KLF6_8969;JUN_8938;ITIH4_32725;ITIH3_32422;ITIH1_33132;IER2_32643;HSPB1_8847;HP_8823;HMGCR_8810;GDF15_33113;GADD45A_8678;FOXO3_8662;FOS_8657;FN1_8655;FGL1_8640;FGA_8632;FETUB_33027;ESR1_33192;EGR1_8533;DUSP6_8506;DDIT4_8450;CYP7A1_8430;CTSC_32456;CPB2_8369;CEBPD_8283;CDKN1A_8271;BHLHE40_8141;ASS1_33159;AMBP_33085;AHSG_8003 36.006163152173954 27.69285 31.052530358928482 24.817838634782635 21.246650000000002 22.382875564238827 60.67924239130436 41.2117 51.22130127605921 0.348134;0.834827;108.064;32.2053;28.261;29.766;15.797;34.1871;36.1411;42.4094;12.4414;63.7758;18.7324;0.520151;45.2017;24.3655;18.9476;16.4324;57.1163;27.1247;98.1741;49.6814;89.1011;64.9285;1.63089;105.149;102.919;13.1992;1.28141E-12;59.5777;15.4757;28.5803;32.5155;23.3972;0.750017;62.3934;87.5421;5.72128;56.2386;25.8316;0.306936;6.24967;57.8085;26.8037;17.2343;12.402 0.118102;0.27095;83.8836;24.3966;22.307;23.347;13.013;26.3085;27.0588;26.2988;8.48981;40.9553;11.6701;0.160202;30.7472;19.538;11.6941;10.5224;39.6402;21.5108;42.9071;33.4626;60.3265;41.6103;0.663137;85.3487;89.5012;5.6804;1.28141E-12;31.0499;10.2138;22.529;19.6094;18.3088;0.186019;39.0875;53.2453;0.985273;38.2681;20.4374;0.0732342;2.44025;38.3491;20.9825;14.1233;10.3013 1.15962;2.99857;143.428;46.6068;38.3264;40.8256;19.9134;48.5666;53.6244;81.7305;79.2355;132.567;41.5978;2.88499;78.6415;32.1467;45.5481;39.929;101.869;36.4819;104.278;89.4404;106.138;136.455;7.6286;125.652;115.437;32.7581;1.28142E-12;105.243;30.4106;38.8511;49.9875;31.9156;4.70178;133.304;245.492;22.3625;102.888;34.8042;1.73689;19.0606;110.58;36.7081;21.9073;15.4235 0 Exp 2,24(0.38);Exp 3,3(0.05);Exp 4,4(0.07);Hill,7(0.11);Linear,10(0.16);Poly 2,14(0.22);Power,2(0.04) 1.8800314300451761 125.07234144210815 1.511321783065796 4.591650485992432 0.6665918628163814 1.7118040919303894 32.999264258802 48.20761964744804 22.54364162868925 33.1405076588108 53.409718705597044 78.66674129440295 DOWN 0.28125 0.71875 0.0 GO:0007339 5 binding of sperm to zona pellucida 9 9 1 1 1 1 1 1 161 8 2377 0.89218 0.44701 0.44701 11.11 83928 fetub FETUB_33027 32.5155 32.5155 32.5155 32.5155 19.6094 19.6094 19.6094 19.609399999999997 49.9875 49.9875 49.9875 49.9875 0.0 32.5155 0.0 32.5155 32.5155 19.6094 49.9875 0 1 0 1 83928 FETUB_33027 32.5155 32.5155 19.6094 19.6094 49.9875 49.9875 32.5155 19.6094 49.9875 0 Poly 2,1(1) 2.1567957401275635 2.1567957401275635 2.1567957401275635 2.1567957401275635 0.0 2.1567957401275635 32.5155 32.5155 19.6094 19.6094 49.9875 49.9875 DOWN 0.0 1.0 0.0 GO:0044283 4 small molecule biosynthetic process 144 161 37 37 24 28 17 17 145 144 2241 0.98829 0.023927 0.029938 10.56 293688;65192;246074;25106;83516;24651;24539;29540;25675;24957;25315;298541;25428;81718;25698;25284;296925 tm7sf2;slc27a2;scd;rgn;ppargc1a;pklr;lpl;hsd17b7;hmgcr;glul;ephx1;dhdds;cyp7a1;cdo1;ass1;amacr;aass TM7SF2_10031;SLC27A2_9860;SCD1_9787;RGN_9699;PPARGC1A_33189;PKLR_9489;LPL_32544;HSD17B7_8834;HMGCR_8810;GLUL_32832;EPHX1_8567;DHDDS_8467;CYP7A1_8430;CDO1_8275;ASS1_33159;AMACR_8038;AASS_7936 34.53098788235294 26.4669 0.977494 32.321407860996075 36.59388052035309 30.739329636950437 23.636835411764704 20.9825 0.322682 21.273605916543048 25.315238481481934 20.166929857933585 75.25319 35.4303 3.73641 105.39670521441326 75.36264109561274 96.9294243105425 7.5 24.781599999999997 15.5 93.88485 82.3097;7.62189;105.46;77.4407;42.4094;23.0963;74.2041;0.977494;1.63089;26.4669;12.4747;47.9438;5.72128;22.9638;26.8037;2.03774;27.4644 51.1696;5.49916;63.7532;58.7732;26.2988;17.4625;49.8682;0.322682;0.663137;21.0456;7.00435;36.5688;0.985273;18.5144;20.9825;1.165;21.7498 209.842;13.3925;422.699;89.8047;81.7305;32.9443;155.425;5.49472;7.6286;35.4303;23.684;71.3742;22.3625;30.0179;36.7081;3.73641;37.0295 8 9 8 65192;246074;25106;24539;25315;298541;25284;296925 SLC27A2_9860;SCD1_9787;RGN_9699;LPL_32544;EPHX1_8567;DHDDS_8467;AMACR_8038;AASS_7936 44.330916249999994 37.704100000000004 38.123944380989734 30.54771375 29.1593 25.16029818984263 102.14316375000001 54.20185 138.69296208791746 7.62189;105.46;77.4407;74.2041;12.4747;47.9438;2.03774;27.4644 5.49916;63.7532;58.7732;49.8682;7.00435;36.5688;1.165;21.7498 13.3925;422.699;89.8047;155.425;23.684;71.3742;3.73641;37.0295 9 293688;83516;24651;29540;25675;24957;25428;81718;25698 TM7SF2_10031;PPARGC1A_33189;PKLR_9489;HSD17B7_8834;HMGCR_8810;GLUL_32832;CYP7A1_8430;CDO1_8275;ASS1_33159 25.81994044444444 23.0963 25.22270469348652 17.493832444444443 18.5144 16.15575137416142 51.350991111111114 32.9443 63.40236773979511 82.3097;42.4094;23.0963;0.977494;1.63089;26.4669;5.72128;22.9638;26.8037 51.1696;26.2988;17.4625;0.322682;0.663137;21.0456;0.985273;18.5144;20.9825 209.842;81.7305;32.9443;5.49472;7.6286;35.4303;22.3625;30.0179;36.7081 0 Exp 2,6(0.36);Exp 4,3(0.18);Hill,3(0.18);Linear,4(0.24);Poly 2,1(0.06) 2.039224740045533 35.98553800582886 1.559399127960205 4.560328960418701 0.7073801454267876 1.9017701148986816 19.16636588141592 49.89560988328996 13.524005088583724 33.74966573494568 25.150776679142204 125.3556033208578 CONFLICT 0.47058823529411764 0.5294117647058824 0.0 GO:1901606 7 alpha-amino acid catabolic process 32 34 4 4 3 4 3 3 159 31 2354 0.83336 0.36878 0.47423 8.82 24443;81718;296925 hdc;cdo1;aass HDC_8788;CDO1_8275;AASS_7936 25.0009 24.5745 22.9638 2.2803975114001345 24.9640049092269 2.642277086609917 20.442033333333335 21.0619 18.5144 1.7044439865637073 20.05586716529544 1.9289428533866357 32.10913333333333 30.0179 29.28 4.277105353312372 32.89207773849188 4.298458830456926 0.5 23.76915 24.5745;22.9638;27.4644 21.0619;18.5144;21.7498 29.28;30.0179;37.0295 2 1 2 24443;296925 HDC_8788;AASS_7936 26.01945 26.01945 2.043467886951038 21.40585 21.40585 0.4864187547781619 33.15475 33.15475 5.479724000805165 24.5745;27.4644 21.0619;21.7498 29.28;37.0295 1 81718 CDO1_8275 22.9638 22.9638 18.5144 18.5144 30.0179 30.0179 22.9638 18.5144 30.0179 0 Exp 2,1(0.34);Linear,2(0.67) 4.078889292281926 21.45084846019745 1.9288111925125122 17.513065338134766 8.974522414788275 2.008971929550171 22.420387290550188 27.581412709449815 18.51327339218934 22.37079327447733 27.269132996242252 36.949133670424416 UP 0.6666666666666666 0.3333333333333333 0.0 GO:1900543 8 negative regulation of purine nucleotide metabolic process 8 8 3 3 3 3 3 3 159 5 2380 0.9991 0.011155 0.011155 37.5 83516;25591;140942 ppargc1a;parp1;ddit4 PPARGC1A_33189;PARP1_9425;DDIT4_8450 52.30853333333334 42.4094 26.9741 31.47404147171656 40.23687665677547 23.679915094435145 33.78103333333333 26.2988 21.799 17.00603738862565 27.405799485657766 12.292740091431332 120.83406666666667 81.7305 35.2797 110.42698702021772 78.71885319485658 81.93552335976447 0.0 26.9741 0.0 26.9741 42.4094;26.9741;87.5421 26.2988;21.799;53.2453 81.7305;35.2797;245.492 1 2 1 25591 PARP1_9425 26.9741 26.9741 21.799 21.799 35.2797 35.2797 26.9741 21.799 35.2797 2 83516;140942 PPARGC1A_33189;DDIT4_8450 64.97575 64.97575 31.91363822325809 39.77205 39.77205 19.054052879243304 163.61124999999998 163.61124999999998 115.79686714728084 42.4094;87.5421 26.2988;53.2453 81.7305;245.492 0 Exp 2,2(0.67);Linear,1(0.34) 1.7435149350091248 5.233509302139282 1.6672165393829346 1.8086696863174438 0.07163343155750215 1.7576230764389038 16.692302553618575 87.92476411304808 14.536890415556492 53.025176251110175 -4.1258326699004755 245.79396600323383 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0046676 8 negative regulation of insulin secretion 10 11 2 2 2 2 2 2 160 9 2376 0.97146 0.15174 0.15174 18.18 25675;113965 hmgcr;hadh HMGCR_8810;HADH_8776 17.471695 17.471695 1.63089 22.402281269907533 28.977932216281893 15.397247037745062 13.198368499999999 13.198368499999999 0.663137 17.727494394786437 22.303546374483595 12.18423281397779 27.3071 27.3071 7.6286 27.82960158715895 41.6009120291616 19.127482841450707 0.0 1.63089 0.5 17.471695 1.63089;33.3125 0.663137;25.7336 7.6286;46.9856 1 1 1 113965 HADH_8776 33.3125 33.3125 25.7336 25.7336 46.9856 46.9856 33.3125 25.7336 46.9856 1 25675 HMGCR_8810 1.63089 1.63089 0.663137 0.663137 7.6286 7.6286 1.63089 0.663137 7.6286 0 Exp 4,1(0.5);Linear,1(0.5) 1.932711253264145 3.865925908088684 1.9017701148986816 1.9641557931900024 0.04411333616871532 1.932962954044342 -13.576282799999998 48.519672799999995 -11.370685239999997 37.76742224 -11.26276 65.87696 CONFLICT 0.5 0.5 0.0 GO:1901700 4 response to oxygen-containing compound 599 638 88 87 67 79 60 60 102 578 1807 0.99984 3.1243E-4 4.8625E-4 9.4 79426;24522;286954;246273;24825;170698;29573;25351;29482;24648;246074;83516;29441;24651;25513;25591;24314;81525;25493;24567;24539;58954;24516;81678;63868;24471;29540;24464;25675;113965;29328;24957;24384;294515;314322;25661;25256;361969;24360;24890;29496;116636;24330;140942;25428;25146;497840;113936;367313;81718;114851;29184;54232;25698;65054;65183;25373;312382;140668;25303 zfp36;zfp354a;ugt2b1;trib3;tf;slco1a2;slc37a4;slc2a2;slc1a2;serpina1;scd;ppargc1a;por;pklr;pik3r1;parp1;nqo1;nfkbib;nfkbia;mt1;lpl;klf6;jun;itpr2;hspd1;hspb1;hsd17b7;hp;hmgcr;hadh;gpx4;glul;gc;foxo3;fos;fn1;fmo1;fga;fabp1;esr1;erbb3;eif4ebp1;egr1;ddit4;cyp7a1;cyp17a1;cps1;cpb2;col6a3;cdo1;cdkn1a;cd36;car3;ass1;aqp9;aldh3a2;ahsg;abcg2;abcc3;abcc2 ZFP36_10204;ZFP354A_10203;UGT2B10_33303,UGT2B1_33224;TRIB3_10079;TF_10003;SLCO1A2_9886;SLC37A4_9871;SLC2A2_9863;SLC1A2_33059;SERPINA1_9807;SCD1_9787;PPARGC1A_33189;POR_9531;PKLR_9489;PIK3R1_32562;PARP1_9425;NQO1_33055;NFKBIB_9308;NFKBIA_9307;MT1A_9255;LPL_32544;KLF6_8969;JUN_8938;ITPR2_8931;HSPD1_8849;HSPB1_8847;HSD17B7_8834;HP_8823;HMGCR_8810;HADH_8776;GPX4_32827;GLUL_32832;GC_32893;FOXO3_8662;FOS_8657;FN1_8655;FMO1_32787;FGA_8632;FABP1_33091;ESR1_33192;ERBB3_8571;EIF4EBP1_8550;EGR1_8533;DDIT4_8450;CYP7A1_8430;CYP17A1_32365;CPS1_32421;CPB2_8369;COL6A3_33029;CDO1_8275;CDKN1A_8271;CD36_8243;CAR3_8196;ASS1_33159;AQP9_32709;ALDH3A2_8024;AHSG_8003;ABCG2_32656;ABCC3_7941;ABCC2_32541 36.95596588333335 31.184150000000002 1.28141E-12 28.51165301517978 38.69488200924928 25.715223164908547 25.21105008333336 23.6434 1.28141E-12 19.385424682383178 26.065761402758067 16.919291702306918 66.69177550000003 45.5686 1.28142E-12 67.65550980333802 67.48287774152246 58.53236273869924 30.5 31.89685 0.348134;0.834827;47.47345;108.064;45.1539;104.197;39.7166;29.7555;13.3235;15.797;105.46;42.4094;12.4414;23.0963;18.7324;26.9741;87.2765;30.5572;0.520151;12.9315;74.2041;18.9476;16.4324;31.8111;42.2579;89.1011;0.977494;64.9285;1.63089;33.3125;45.9204;26.4669;42.356;13.1992;1.28141E-12;59.5777;65.2792;28.5803;33.8478;23.3972;60.9984;83.9001;0.750017;87.5421;5.72128;49.6922;31.9826;25.8316;63.132;22.9638;6.24967;48.1296;53.9626;26.8037;27.7316;43.1079;12.402;5.21654;37.7175;46.2316 0.118102;0.27095;34.82915;83.8836;28.132;80.3101;22.6911;23.3399;9.10952;13.013;63.7532;26.2988;8.48981;17.4625;11.6701;21.799;60.6992;24.2439;0.160202;8.91033;49.8682;11.6941;10.5224;24.7342;23.9469;60.3265;0.322682;41.6103;0.663137;25.7336;34.2198;21.0456;26.3722;5.6804;1.28141E-12;31.0499;39.7882;22.529;26.4736;18.3088;41.6036;42.4185;0.186019;53.2453;0.985273;35.6654;24.4836;20.4374;42.651;18.5144;2.44025;37.5433;28.5034;20.9825;21.9372;31.8774;10.3013;2.73368;30.9007;31.1788 1.15962;2.99857;76.47475;143.428;61.5341;128.412;60.0334;40.808;24.6773;19.9134;422.699;81.7305;79.2355;32.9443;41.5978;35.2797;197.117;41.2611;2.88499;23.4636;155.425;45.5481;39.929;44.3296;102.383;106.138;5.49472;136.455;7.6286;46.9856;70.4292;35.4303;78.7583;32.7581;1.28142E-12;105.243;82.9415;38.8511;46.9257;31.9156;113.972;107.32;4.70178;245.492;22.3625;81.6409;45.5891;34.8042;121.149;30.0179;19.0606;69.1421;77.0288;36.7081;37.4625;66.3058;15.4235;11.386;48.9329;81.7848 20 41 19 286954;24825;246074;25591;24314;81525;24539;63868;113965;29328;25256;24360;29496;116636;25146;29184;65183;312382;140668 UGT2B10_33303,UGT2B1_33224;TF_10003;SCD1_9787;PARP1_9425;NQO1_33055;NFKBIB_9308;LPL_32544;HSPD1_8849;HADH_8776;GPX4_32827;FMO1_32787;FABP1_33091;ERBB3_8571;EIF4EBP1_8550;CYP17A1_32365;CD36_8243;ALDH3A2_8024;ABCG2_32656;ABCC3_7941 50.86733105263158 45.9204 23.923575624593717 34.538385789473686 34.2198 13.981861582872808 96.74501842105263 70.4292 90.07440997036717 47.47345;45.1539;105.46;26.9741;87.2765;30.5572;74.2041;42.2579;33.3125;45.9204;65.2792;33.8478;60.9984;83.9001;49.6922;48.1296;43.1079;5.21654;37.7175 34.82915;28.132;63.7532;21.799;60.6992;24.2439;49.8682;23.9469;25.7336;34.2198;39.7882;26.4736;41.6036;42.4185;35.6654;37.5433;31.8774;2.73368;30.9007 76.47475;61.5341;422.699;35.2797;197.117;41.2611;155.425;102.383;46.9856;70.4292;82.9415;46.9257;113.972;107.32;81.6409;69.1421;66.3058;11.386;48.9329 41 79426;24522;246273;170698;29573;25351;29482;24648;83516;29441;24651;25513;25493;24567;58954;24516;81678;24471;29540;24464;25675;24957;24384;294515;314322;25661;361969;24890;24330;140942;25428;497840;113936;367313;81718;114851;54232;25698;65054;25373;25303 ZFP36_10204;ZFP354A_10203;TRIB3_10079;SLCO1A2_9886;SLC37A4_9871;SLC2A2_9863;SLC1A2_33059;SERPINA1_9807;PPARGC1A_33189;POR_9531;PKLR_9489;PIK3R1_32562;NFKBIA_9307;MT1A_9255;KLF6_8969;JUN_8938;ITPR2_8931;HSPB1_8847;HSD17B7_8834;HP_8823;HMGCR_8810;GLUL_32832;GC_32893;FOXO3_8662;FOS_8657;FN1_8655;FGA_8632;ESR1_33192;EGR1_8533;DDIT4_8450;CYP7A1_8430;CPS1_32421;CPB2_8369;COL6A3_33029;CDO1_8275;CDKN1A_8271;CAR3_8196;ASS1_33159;AQP9_32709;AHSG_8003;ABCC2_32541 30.509235682926857 23.3972 28.40726295856966 20.88862621951223 18.5144 20.14573196146776 52.7646629268293 37.4625 49.72532820153822 0.348134;0.834827;108.064;104.197;39.7166;29.7555;13.3235;15.797;42.4094;12.4414;23.0963;18.7324;0.520151;12.9315;18.9476;16.4324;31.8111;89.1011;0.977494;64.9285;1.63089;26.4669;42.356;13.1992;1.28141E-12;59.5777;28.5803;23.3972;0.750017;87.5421;5.72128;31.9826;25.8316;63.132;22.9638;6.24967;53.9626;26.8037;27.7316;12.402;46.2316 0.118102;0.27095;83.8836;80.3101;22.6911;23.3399;9.10952;13.013;26.2988;8.48981;17.4625;11.6701;0.160202;8.91033;11.6941;10.5224;24.7342;60.3265;0.322682;41.6103;0.663137;21.0456;26.3722;5.6804;1.28141E-12;31.0499;22.529;18.3088;0.186019;53.2453;0.985273;24.4836;20.4374;42.651;18.5144;2.44025;28.5034;20.9825;21.9372;10.3013;31.1788 1.15962;2.99857;143.428;128.412;60.0334;40.808;24.6773;19.9134;81.7305;79.2355;32.9443;41.5978;2.88499;23.4636;45.5481;39.929;44.3296;106.138;5.49472;136.455;7.6286;35.4303;78.7583;32.7581;1.28142E-12;105.243;38.8511;31.9156;4.70178;245.492;22.3625;45.5891;34.8042;121.149;30.0179;19.0606;77.0288;36.7081;37.4625;15.4235;81.7848 0 Exp 2,21(0.35);Exp 3,3(0.05);Exp 4,6(0.1);Hill,5(0.09);Linear,12(0.2);Poly 2,13(0.22);Power,1(0.02) 1.953215269684206 124.35666739940643 1.5074360370635986 4.591650485992432 0.7147239298642887 1.8264755010604858 29.74152227302516 44.170409493641564 20.305860855670172 30.116239310996537 49.572569533830006 83.81098146617009 DOWN 0.31666666666666665 0.6833333333333333 0.0 GO:0002573 6 myeloid leukocyte differentiation 36 39 3 3 3 3 3 3 159 36 2349 0.76649 0.4561 0.73503 7.69 24825;363465;24516 tf;pir;jun TF_10003;PIR_9487;JUN_8938 37.205666666666666 45.1539 16.4324 18.154675721789495 41.623634429188776 15.403993335578019 25.8087 28.132 10.5224 14.267236235164825 29.200890952354907 12.673413458091485 58.15713333333334 61.5341 39.929 16.796218325067457 62.17786087194356 14.804149967920308 0.5 30.79315 45.1539;50.0307;16.4324 28.132;38.7717;10.5224 61.5341;73.0083;39.929 2 1 2 24825;363465 TF_10003;PIR_9487 47.5923 47.5923 3.4484183504904795 33.45185 33.45185 7.523404019790535 67.27120000000001 67.27120000000001 8.113484628690525 45.1539;50.0307 28.132;38.7717 61.5341;73.0083 1 24516 JUN_8938 16.4324 16.4324 10.5224 10.5224 39.929 39.929 16.4324 10.5224 39.929 0 Exp 2,1(0.34);Poly 2,2(0.67) 1.9023885748230804 5.709898948669434 1.8344712257385254 1.9785058498382568 0.07222880491434591 1.8969218730926514 16.66171711321661 57.74961622011672 9.66380234530979 41.953597654690206 39.15042303749626 77.16384362917043 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0043153 5 entrainment of circadian clock by photoperiod 7 7 1 1 1 1 1 1 161 6 2379 0.93166 0.36908 0.36908 14.29 79431 bhlhe40 BHLHE40_8141 57.8085 57.8085 57.8085 57.8085 38.3491 38.3491 38.3491 38.3491 110.58 110.58 110.58 110.58 0.0 57.8085 0.0 57.8085 57.8085 38.3491 110.58 0 1 0 1 79431 BHLHE40_8141 57.8085 57.8085 38.3491 38.3491 110.58 110.58 57.8085 38.3491 110.58 0 Exp 2,1(1) 1.7037216424942017 1.7037216424942017 1.7037216424942017 1.7037216424942017 0.0 1.7037216424942017 57.8085 57.8085 38.3491 38.3491 110.58 110.58 DOWN 0.0 1.0 0.0 GO:0008150 1 biological_process 2293 2547 243 240 181 216 162 162 0 2385 0 1.0 1.0 1.0 6.36 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zwint;zfp36;zfp354a;usp18;ugt2b1;tubb4b;ttr;tsku;trib3;tm7sf2;timm9;thrsp;tf;sult2a2;sult1e1;stac3;slco1a2;slc37a4;slc2a2;slc27a2;slc25a30;slc1a2;slc10a2;sirt3;serpind1;serpina3c;serpina1;scd;rrs1;rgn;rgd1559459;rgd1307603;rab30;pzp;psmb3;ppp1r3b;ppcs;ppargc1a;ppan;por;polg2;plin2;plg;pklr;pir;pik3r1;pdia5;pax8;parp1;papss2;nqo1;nfkbib;nfkbia;mt1;mpc2;me1;lpl;loc299282;laptm5;lama3;kng1;klf6;jun;itpr2;itih4;itih3;itih1;igfbp1;ier2;iars2;hyou1;htra1;hspd1;hspb1;hsd17b7;hsd17b11;hp;hmgcr;hdc;hadhb;hadh;hacl1;gstm7;gstm3l;gpx4;gnl3;glul;gins1;gdf15;gc;gale;gadd45b;gadd45a;g0s2;foxo3;fos;fn1;fmo3;fmo1;fgl1;fga;fetub;fabp7;fabp1;f5;exosc5;etfdh;esr1;erbb3;ephx2;ephx1;eif4ebp1;ehhadh;egr1;eci2;eci1;dusp6;dhdds;ddit4;cyp7a1;cyp3a2;cyp2j4;cyp2a1;cyp17a1;ctsc;crot;cps1;cpb2;col6a3;cndp2;chrna2;chpt1;cebpd;cdo1;cdkn1a;cd36;car3;c8b;bphl;bmf;bhlhe40;ass1;aqp9;anxa7;ampd1;ambp;amacr;aldh3a2;ahsg;agmo;acox1;acot2;acot12;acot1;acadm;acadl;acaa2;abhd1;abcg2;abcc3;abcc2;aass ZWINT_10214;ZFP36_10204;ZFP354A_10203;USP18_10138;UGT2B10_33303,UGT2B1_33224;TUBB4B_34097;TTR_10102;TSKU_10094;TRIB3_10079;TM7SF2_10031;TIMM9_10020;THRSP_33314;TF_10003;SULT2A2_33196;SULT1E1_32446;STAC3_9953;SLCO1A2_9886;SLC37A4_9871;SLC2A2_9863;SLC27A2_9860;SLC25A30_9856;SLC1A2_33059;SLC10A2_9833;SIRT3_9828;SERPIND1_9812;SERPINA3C_32925;SERPINA1_9807;SCD1_9787;RRS1_9755;RGN_9699;RGD1559459_9690;RGD1307603_9684;RAB30_9639;PZP_9633;PSMB3_9589;PPP1R3B_9545;PPCS_9540;PPARGC1A_33189;PPAN_9534;POR_9531;POLG2_9521;PLIN2_9502;PLG_9501;PKLR_9489;PIR_9487;PIK3R1_32562;PDIA5_9451;PAX8_9432;PARP1_9425;PAPSS2_33237;NQO1_33055;NFKBIB_9308;NFKBIA_9307;MT1A_9255;MPC2_33219;ME1_9215;LPL_32544;LOC299282_9119;LAPTM5_32639;LAMA3_8980;KNG1L1_34113;KLF6_8969;JUN_8938;ITPR2_8931;ITIH4_32725;ITIH3_32422;ITIH1_33132;IGFBP1_32306;IER2_32643;IARS2_8858;HYOU1_8857;HTRA1_8856;HSPD1_8849;HSPB1_8847;HSD17B7_8834;HSD17B11_8832;HP_8823;HMGCR_8810;HDC_8788;HADHB_8777;HADH_8776;HACL1_8775;GSTM7_8761;GSTM3_8760;GPX4_32827;GNL3_8735;GLUL_32832;GINS1_8707;GDF15_33113;GC_32893;GALE_8680;GADD45B_8679;GADD45A_8678;G0S2_32729;FOXO3_8662;FOS_8657;FN1_8655;FMO3_8654;FMO1_32787;FGL1_8640;FGA_8632;FETUB_33027;FABP7_8592;FABP1_33091;F5_33079;EXOSC5_32543;ETFDH_8575;ESR1_33192;ERBB3_8571;EPHX2_33282;EPHX1_8567;EIF4EBP1_8550;EHHADH_8534;EGR1_8533;ECI2_8521;ECI1_8520;DUSP6_8506;DHDDS_8467;DDIT4_8450;CYP7A1_8430;CYP3A2_32374;CYP2J4_32580;CYP2A1_32717;CYP17A1_32365;CTSC_32456;CROT_8384;CPS1_32421;CPB2_8369;COL6A3_33029;CNDP2_8341;CHRNA2_32401;CHPT1_33298;CEBPD_8283;CDO1_8275;CDKN1A_8271;CD36_8243;CAR3_8196;C8B_8181;BPHL_8157;BMF_8152;BHLHE40_8141;ASS1_33159;AQP9_32709;ANXA7_8051;AMPD1_32743;AMBP_33085;AMACR_8038;ALDH3A2_8024;AHSG_8003;AGMO_33265;ACOX1_7973;ACOT2_7969;ACOT12_32718;ACOT1_7968;ACADM_7957;ACADL_32776;ACAA2_7955;ABHD1_7949;ABCG2_32656;ABCC3_7941;ABCC2_32541;AASS_7936 171139(0.04986) 39.7249409197531 33.5159 2.52378E-13 27.83473782364304 41.21797384645072 26.612299590642216 27.616218569135807 25.66675 2.52378E-13 18.778448431574116 28.77468616809691 18.42565887978037 64.78497975308643 47.7761 2.52379E-13 53.9922556642775 66.01957226665586 48.53169427714407 126.5 59.2471 52.0003;0.348134;0.834827;108.883;47.47345;62.7603;46.6406;1.38416;108.064;82.3097;38.5191;32.2053;45.1539;54.1932;50.1846;63.2393;104.197;39.7166;29.7555;7.62189;53.013;13.3235;56.585;2.38018;28.261;29.766;15.797;105.46;60.39;77.4407;2.52378E-13;34.7372;26.4203;34.1871;23.7888;36.1411;20.3353;42.4094;57.6889;12.4414;63.7758;25.6517;70.7857;23.0963;50.0307;18.7324;107.066;56.8931;26.9741;34.4443;87.2765;30.5572;0.520151;12.9315;46.8463;80.7944;74.2041;45.2017;38.674;2.46923;24.3655;18.9476;16.4324;31.8111;57.1163;27.1247;98.1741;49.0259;49.6814;24.7304;40.1982;33.1323;42.2579;89.1011;0.977494;22.4334;64.9285;1.63089;24.5745;31.8029;33.3125;17.6275;42.3152;73.0961;45.9204;87.6357;26.4669;58.9165;105.149;42.356;71.148;106.367;102.919;46.3784;13.1992;1.28141E-12;59.5777;62.8595;65.2792;15.4757;28.5803;32.5155;24.601;33.8478;10.6089;41.9329;18.1231;23.3972;60.9984;38.7293;12.4747;83.9001;8.62809;0.750017;10.6467;11.9473;62.3934;47.9438;87.5421;5.72128;12.8505;17.8395;55.3937;49.6922;56.2386;7.4229;31.9826;25.8316;63.132;33.544;49.3913;16.0559;0.306936;22.9638;6.24967;48.1296;53.9626;21.3618;12.3152;94.8767;57.8085;26.8037;27.7316;104.64;60.9045;17.2343;2.03774;43.1079;12.402;31.5332;23.1906;8.54905;30.3423;31.2018;11.7137;33.4878;26.5872;17.2895;5.21654;37.7175;46.2316;27.4644 38.9015;0.118102;0.27095;73.1414;34.82915;47.0916;28.5876;0.540568;83.8836;51.1696;29.55;24.3966;28.132;35.5514;36.5009;42.7031;80.3101;22.6911;23.3399;5.49916;37.4804;9.10952;35.2796;0.56209;22.307;23.347;13.013;63.7532;43.109;58.7732;2.52378E-13;26.1766;21.0125;26.3085;19.2724;27.0588;16.7643;26.2988;41.3659;8.48981;40.9553;20.9252;46.2356;17.4625;38.7717;11.6701;61.3361;45.1162;21.799;25.719;60.6992;24.2439;0.160202;8.91033;35.8494;59.856;49.8682;30.7472;24.6273;0.871501;19.538;11.6941;10.5224;24.7342;39.6402;21.5108;42.9071;32.6883;33.4626;19.8021;29.3844;25.6145;23.9469;60.3265;0.322682;18.1233;41.6103;0.663137;21.0619;25.5756;25.7336;11.195;31.4035;51.4219;34.2198;54.41;21.0456;44.7208;85.3487;26.3722;43.2839;52.7132;89.5012;33.7914;5.6804;1.28141E-12;31.0499;42.5185;39.7882;10.2138;22.529;19.6094;14.4402;26.4736;2.59129;31.7336;14.869;18.3088;41.6036;29.2097;7.00435;42.4185;7.31865;0.186019;8.92359;7.15307;39.0875;36.5688;53.2453;0.985273;7.33176;14.6501;38.7444;35.6654;38.2681;5.75707;24.4836;20.4374;42.651;26.3005;41.8524;10.6021;0.0732342;18.5144;2.44025;37.5433;28.5034;17.2088;6.6063;73.1342;38.3491;20.9825;21.9372;43.9254;50.0633;14.1233;1.165;31.8774;10.3013;24.5474;16.2815;7.19676;24.0157;26.858;8.36151;26.6039;21.3695;14.2242;2.73368;30.9007;31.1788;21.7498 80.8613;1.15962;2.99857;138.144;76.47475;101.528;63.7146;4.10872;143.428;209.842;55.4685;46.6068;61.5341;103.141;80.9788;121.52;128.412;60.0334;40.808;13.3925;90.2594;24.6773;116.8;8.82917;38.3264;40.8256;19.9134;422.699;104.942;89.8047;2.52379E-13;50.9085;35.3561;48.5666;30.901;53.6244;25.6711;81.7305;98.1741;79.2355;132.567;33.0375;150.579;32.9443;73.0083;41.5978;114.259;81.5688;35.2797;51.1014;197.117;41.2611;2.88499;23.4636;69.127;94.0621;155.425;78.6415;71.0786;10.4175;32.1467;45.5481;39.929;44.3296;101.869;36.4819;104.278;89.1623;89.4404;32.7087;62.3571;46.6629;102.383;106.138;5.49472;29.2247;136.455;7.6286;29.28;42.1484;46.9856;37.6534;64.5991;140.853;70.4292;238.963;35.4303;91.837;125.652;78.7583;88.9033;109.434;115.437;73.6529;32.7581;1.28142E-12;105.243;120.21;82.9415;30.4106;38.8511;49.9875;35.6155;46.9257;37.5078;62.1373;23.0103;31.9156;113.972;57.2113;23.684;107.32;10.3909;4.70178;13.0581;19.001;133.304;71.3742;245.492;22.3625;24.0283;22.6149;96.8569;81.6409;102.888;10.316;45.5891;34.8042;121.149;46.311;62.472;29.905;1.73689;30.0179;19.0606;69.1421;77.0288;27.9161;25.5051;109.848;110.58;36.7081;37.4625;108.689;82.6625;21.9073;3.73641;66.3058;15.4235;43.8459;33.4539;10.4125;41.1025;37.2719;18.9642;45.3228;35.0407;21.8526;11.386;48.9329;81.7848;37.0295 81 82 80 257644;312688;286954;296554;24856;171139;24825;360268;65192;361074;293615;246074;297784;25106;308821;29676;298490;298699;298199;363465;81819;25591;24314;81525;100359982;24539;364070;63868;289456;24443;171155;113965;85255;81869;57298;29328;290556;499914;299626;289388;25256;80841;24360;308441;295143;29496;65030;25315;116636;171142;291075;29740;298541;266682;65210;24894;25146;83842;291394;170945;362866;29184;361239;246142;155423;25028;25284;65183;362732;50681;192272;170570;50559;24158;25287;170465;313917;312382;140668;296925 ZWINT_10214;USP18_10138;UGT2B10_33303,UGT2B1_33224;TUBB4B_34097;TTR_10102;TIMM9_10020;TF_10003;SULT1E1_32446;SLC27A2_9860;SLC25A30_9856;SIRT3_9828;SCD1_9787;RRS1_9755;RGN_9699;RAB30_9639;PSMB3_9589;PPCS_9540;PPAN_9534;PLIN2_9502;PIR_9487;PAX8_9432;PARP1_9425;NQO1_33055;NFKBIB_9308;MPC2_33219;LPL_32544;IARS2_8858;HSPD1_8849;HSD17B11_8832;HDC_8788;HADHB_8777;HADH_8776;HACL1_8775;GSTM7_8761;GSTM3_8760;GPX4_32827;GNL3_8735;GINS1_8707;GADD45B_8679;G0S2_32729;FMO1_32787;FABP7_8592;FABP1_33091;EXOSC5_32543;ETFDH_8575;ERBB3_8571;EPHX2_33282;EPHX1_8567;EIF4EBP1_8550;EHHADH_8534;ECI2_8521;ECI1_8520;DHDDS_8467;CYP3A2_32374;CYP2J4_32580;CYP2A1_32717;CYP17A1_32365;CROT_8384;CNDP2_8341;CHRNA2_32401;CHPT1_33298;CD36_8243;BPHL_8157;BMF_8152;ANXA7_8051;AMPD1_32743;AMACR_8038;ALDH3A2_8024;AGMO_33265;ACOX1_7973;ACOT2_7969;ACOT12_32718;ACOT1_7968;ACADM_7957;ACADL_32776;ACAA2_7955;ABHD1_7949;ABCG2_32656;ABCC3_7941;AASS_7936 41.16880049999999 38.118300000000005 26.192566087303423 29.091052999999995 27.495 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80.8613;138.144;76.47475;101.528;63.7146;55.4685;61.5341;80.9788;13.3925;90.2594;8.82917;422.699;104.942;89.8047;35.3561;30.901;25.6711;98.1741;33.0375;73.0083;81.5688;35.2797;197.117;41.2611;69.127;155.425;32.7087;102.383;29.2247;29.28;42.1484;46.9856;37.6534;64.5991;140.853;70.4292;238.963;91.837;109.434;73.6529;82.9415;35.6155;46.9257;62.1373;23.0103;113.972;57.2113;23.684;107.32;10.3909;13.0581;19.001;71.3742;24.0283;22.6149;96.8569;81.6409;10.316;46.311;62.472;29.905;69.1421;25.5051;109.848;108.689;82.6625;3.73641;66.3058;43.8459;33.4539;10.4125;41.1025;37.2719;18.9642;45.3228;35.0407;21.8526;11.386;48.9329;37.0295 82 79426;24522;308843;246273;293688;25357;361510;362895;170698;29573;25351;29482;29500;79224;24794;24648;501907;293656;252922;192280;83516;29441;303612;85253;24651;25513;360722;294103;25493;24567;24552;299282;89783;307582;288001;58954;24516;81678;54404;50693;306251;25685;494344;192235;65164;24471;29540;24464;25675;24957;29455;24384;114860;25112;294515;314322;25661;84493;246186;361969;83928;304929;24890;24330;116663;140942;25428;25423;497840;113936;367313;25695;81718;114851;54232;313421;79431;25698;65054;25377;25373;25303 ZFP36_10204;ZFP354A_10203;TSKU_10094;TRIB3_10079;TM7SF2_10031;THRSP_33314;SULT2A2_33196;STAC3_9953;SLCO1A2_9886;SLC37A4_9871;SLC2A2_9863;SLC1A2_33059;SLC10A2_9833;SERPIND1_9812;SERPINA3C_32925;SERPINA1_9807;RGD1559459_9690;RGD1307603_9684;PZP_9633;PPP1R3B_9545;PPARGC1A_33189;POR_9531;POLG2_9521;PLG_9501;PKLR_9489;PIK3R1_32562;PDIA5_9451;PAPSS2_33237;NFKBIA_9307;MT1A_9255;ME1_9215;LOC299282_9119;LAPTM5_32639;LAMA3_8980;KNG1L1_34113;KLF6_8969;JUN_8938;ITPR2_8931;ITIH4_32725;ITIH3_32422;ITIH1_33132;IGFBP1_32306;IER2_32643;HYOU1_8857;HTRA1_8856;HSPB1_8847;HSD17B7_8834;HP_8823;HMGCR_8810;GLUL_32832;GDF15_33113;GC_32893;GALE_8680;GADD45A_8678;FOXO3_8662;FOS_8657;FN1_8655;FMO3_8654;FGL1_8640;FGA_8632;FETUB_33027;F5_33079;ESR1_33192;EGR1_8533;DUSP6_8506;DDIT4_8450;CYP7A1_8430;CTSC_32456;CPS1_32421;CPB2_8369;COL6A3_33029;CEBPD_8283;CDO1_8275;CDKN1A_8271;CAR3_8196;C8B_8181;BHLHE40_8141;ASS1_33159;AQP9_32709;AMBP_33085;AHSG_8003;ABCC2_32541 38.31629742682928 32.09395 29.441491116351173 26.177355709756117 23.8718 20.608049774506004 63.770318170731706 46.63485 49.15358814719452 0.348134;0.834827;1.38416;108.064;82.3097;32.2053;54.1932;63.2393;104.197;39.7166;29.7555;13.3235;56.585;28.261;29.766;15.797;2.52378E-13;34.7372;34.1871;36.1411;42.4094;12.4414;63.7758;70.7857;23.0963;18.7324;107.066;34.4443;0.520151;12.9315;80.7944;45.2017;38.674;2.46923;24.3655;18.9476;16.4324;31.8111;57.1163;27.1247;98.1741;49.0259;49.6814;40.1982;33.1323;89.1011;0.977494;64.9285;1.63089;26.4669;105.149;42.356;71.148;102.919;13.1992;1.28141E-12;59.5777;62.8595;15.4757;28.5803;32.5155;10.6089;23.3972;0.750017;62.3934;87.5421;5.72128;56.2386;31.9826;25.8316;63.132;0.306936;22.9638;6.24967;53.9626;21.3618;57.8085;26.8037;27.7316;17.2343;12.402;46.2316 0.118102;0.27095;0.540568;83.8836;51.1696;24.3966;35.5514;42.7031;80.3101;22.6911;23.3399;9.10952;35.2796;22.307;23.347;13.013;2.52378E-13;26.1766;26.3085;27.0588;26.2988;8.48981;40.9553;46.2356;17.4625;11.6701;61.3361;25.719;0.160202;8.91033;59.856;30.7472;24.6273;0.871501;19.538;11.6941;10.5224;24.7342;39.6402;21.5108;42.9071;32.6883;33.4626;29.3844;25.6145;60.3265;0.322682;41.6103;0.663137;21.0456;85.3487;26.3722;43.2839;89.5012;5.6804;1.28141E-12;31.0499;42.5185;10.2138;22.529;19.6094;2.59129;18.3088;0.186019;39.0875;53.2453;0.985273;38.2681;24.4836;20.4374;42.651;0.0732342;18.5144;2.44025;28.5034;17.2088;38.3491;20.9825;21.9372;14.1233;10.3013;31.1788 1.15962;2.99857;4.10872;143.428;209.842;46.6068;103.141;121.52;128.412;60.0334;40.808;24.6773;116.8;38.3264;40.8256;19.9134;2.52379E-13;50.9085;48.5666;53.6244;81.7305;79.2355;132.567;150.579;32.9443;41.5978;114.259;51.1014;2.88499;23.4636;94.0621;78.6415;71.0786;10.4175;32.1467;45.5481;39.929;44.3296;101.869;36.4819;104.278;89.1623;89.4404;62.3571;46.6629;106.138;5.49472;136.455;7.6286;35.4303;125.652;78.7583;88.9033;115.437;32.7581;1.28142E-12;105.243;120.21;30.4106;38.8511;49.9875;37.5078;31.9156;4.70178;133.304;245.492;22.3625;102.888;45.5891;34.8042;121.149;1.73689;30.0179;19.0606;77.0288;27.9161;110.58;36.7081;37.4625;21.9073;15.4235;81.7848 0 Exp 2,65(0.4);Exp 3,6(0.04);Exp 4,9(0.06);Hill,15(0.1);Linear,38(0.24);Poly 2,26(0.16);Power,4(0.03) 2.1370040380572624 744.6644868850708 1.5074360370635986 344.14306640625 26.92913203307992 1.7706087827682495 35.43860997968759 44.011271859818585 24.724485044334617 30.50795209393701 56.470596573190186 73.09936293298264 CONFLICT 0.49382716049382713 0.5061728395061729 0.0 GO:0046164 5 alcohol catabolic process 12 13 3 3 3 2 2 2 160 11 2374 0.95495 0.19842 0.19842 15.38 360268;25428 sult1e1;cyp7a1 SULT1E1_32446;CYP7A1_8430 27.95294 27.95294 5.72128 31.440315086067447 41.54392190859233 24.880993433378666 18.7430865 18.7430865 0.985273 25.113340689792043 29.599051462340036 19.874001360432082 51.67065 51.67065 22.3625 41.44798321806504 69.58773475319929 32.80078445309419 0.0 5.72128 0.5 27.95294 50.1846;5.72128 36.5009;0.985273 80.9788;22.3625 1 1 1 360268 SULT1E1_32446 50.1846 50.1846 36.5009 36.5009 80.9788 80.9788 50.1846 36.5009 80.9788 1 25428 CYP7A1_8430 5.72128 5.72128 0.985273 0.985273 22.3625 22.3625 5.72128 0.985273 22.3625 0 Exp 2,1(0.5);Hill,1(0.5) 2.8170406990110735 6.300492525100708 1.7401635646820068 4.560328960418701 1.99415807539306 3.150246262550354 -15.62111359999999 71.5269936 -16.062227959999998 53.548400959999995 -5.7733240000000094 109.11462400000002 CONFLICT 0.5 0.5 0.0 GO:2000279 8 negative regulation of DNA biosynthetic process 13 13 2 2 2 2 2 2 160 11 2374 0.95495 0.19842 0.19842 15.38 25106;114851 rgn;cdkn1a RGN_9699;CDKN1A_8271 41.845185 41.845185 6.24967 50.339660072654944 32.333822661500534 48.50927075479488 30.606725 30.606725 2.44025 39.833410949242726 23.080452391687217 38.38503704703138 54.432649999999995 54.432649999999995 19.0606 50.023632838939236 44.980999020781965 48.20473451787794 0.0 6.24967 0.5 41.845185 77.4407;6.24967 58.7732;2.44025 89.8047;19.0606 1 1 1 25106 RGN_9699 77.4407 77.4407 58.7732 58.7732 89.8047 89.8047 77.4407 58.7732 89.8047 1 114851 CDKN1A_8271 6.24967 6.24967 2.44025 2.44025 19.0606 19.0606 6.24967 2.44025 19.0606 0 Exp 4,1(0.5);Poly 2,1(0.5) 1.6179760928444218 3.241990804672241 1.522104263305664 1.7198865413665771 0.13985319001539498 1.6209954023361206 -27.922024400000012 111.61239440000001 -24.599566 85.813016 -14.896568000000002 123.76186799999999 CONFLICT 0.5 0.5 0.0 GO:0030182 5 neuron differentiation 63 68 3 3 2 3 2 2 160 66 2319 0.18106 0.93803 0.3187 2.94 494344;140942 ier2;ddit4 IER2_32643;DDIT4_8450 68.61175 68.61175 49.6814 26.771557710469526 57.6158552501916 21.792129302738523 43.35395 43.35395 33.4626 13.988481320179124 37.60845435234863 11.386666288718455 167.4662 167.4662 89.4404 110.34514457501064 122.14408579875176 89.82128288962497 49.6814;87.5421 33.4626;53.2453 89.4404;245.492 0 2 0 2 494344;140942 IER2_32643;DDIT4_8450 68.61175 68.61175 26.771557710469526 43.35395 43.35395 13.988481320179124 167.4662 167.4662 110.34514457501064 49.6814;87.5421 33.4626;53.2453 89.4404;245.492 0 Exp 2,1(0.5);Linear,1(0.5) 1.7153087166745526 3.432004690170288 1.6672165393829346 1.7647881507873535 0.06899354807536331 1.716002345085144 31.508263999999997 105.715236 23.966904000000003 62.740995999999996 14.53563200000005 320.39676799999995 DOWN 0.0 1.0 0.0 GO:0019373 7 epoxygenase P450 pathway 10 13 5 5 4 3 2 2 160 11 2374 0.95495 0.19842 0.19842 15.38 65210;24894 cyp2j4;cyp2a1 CYP2J4_32580;CYP2A1_32717 36.616600000000005 36.616600000000005 17.8395 26.55482948203584 29.562638317231027 24.609799226650644 26.69725 26.69725 14.6501 17.037242917943022 22.171517352968763 15.789336093078495 59.7359 59.7359 22.6149 52.49702164885164 45.790716152330916 48.6518342604821 0.0 17.8395 0.5 36.616600000000005 17.8395;55.3937 14.6501;38.7444 22.6149;96.8569 2 0 2 65210;24894 CYP2J4_32580;CYP2A1_32717 36.616600000000005 36.616600000000005 26.55482948203584 26.69725 26.69725 17.037242917943022 59.7359 59.7359 52.49702164885164 17.8395;55.3937 14.6501;38.7444 22.6149;96.8569 0 0 Linear,2(1) 2.5238439315918084 5.480727314949036 1.672747254371643 3.8079800605773926 1.5098375966800668 2.740363657474518 -0.18651599999999036 73.419716 3.084836000000003 50.30966399999999 -13.021259999999991 132.49305999999999 UP 1.0 0.0 0.0 GO:0097237 5 cellular response to toxic substance 71 80 12 12 12 9 9 9 153 71 2314 0.97193 0.064342 0.095981 11.25 286954;83516;24314;58954;81678;24471;24360;24330;497840 ugt2b1;ppargc1a;nqo1;klf6;itpr2;hspb1;fabp1;egr1;cps1 UGT2B10_33303,UGT2B1_33224;PPARGC1A_33189;NQO1_33055;KLF6_8969;ITPR2_8931;HSPB1_8847;FABP1_33091;EGR1_8533;CPS1_32421 42.62217411111111 33.8478 0.750017 29.151998270212886 40.0167332884198 26.679626344861838 29.969463222222227 26.2988 0.186019 19.980374480467347 28.382010450185813 18.127980306171906 72.06161444444444 46.9257 4.70178 55.06246362994602 60.89552486962985 37.667476480818635 3.0 31.9826 7.0 87.2765 47.47345;42.4094;87.2765;18.9476;31.8111;89.1011;33.8478;0.750017;31.9826 34.82915;26.2988;60.6992;11.6941;24.7342;60.3265;26.4736;0.186019;24.4836 76.47475;81.7305;197.117;45.5481;44.3296;106.138;46.9257;4.70178;45.5891 4 6 3 286954;24314;24360 UGT2B10_33303,UGT2B1_33224;NQO1_33055;FABP1_33091 56.19925 47.47345 27.762586067448773 40.667316666666665 34.82915 17.844076506248047 106.83915 76.47475 79.56666537842652 47.47345;87.2765;33.8478 34.82915;60.6992;26.4736 76.47475;197.117;46.9257 6 83516;58954;81678;24471;24330;497840 PPARGC1A_33189;KLF6_8969;ITPR2_8931;HSPB1_8847;EGR1_8533;CPS1_32421 35.83363616666667 31.89685 29.757934072277397 24.6205365 24.6089 20.208426335968706 54.672846666666665 45.5686 35.073192960371706 42.4094;18.9476;31.8111;89.1011;0.750017;31.9826 26.2988;11.6941;24.7342;60.3265;0.186019;24.4836 81.7305;45.5481;44.3296;106.138;4.70178;45.5891 0 Exp 2,6(0.6);Hill,1(0.1);Linear,1(0.1);Poly 2,2(0.2) 1.8687199633460372 19.608322620391846 1.5740432739257812 4.21828556060791 0.7994655793821914 1.727470338344574 23.57620190790536 61.66814631431686 16.91561856165022 43.02330788279422 36.08747153954638 108.0357573493425 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0043170 4 macromolecule metabolic process 853 925 62 61 48 56 44 44 118 881 1504 0.0069395 0.99582 0.014115 4.76 79426;312688;246273;24825;29573;293615;297784;29676;192280;29441;303612;85253;25513;81819;25591;24516;54404;50693;306251;364070;65164;63868;24464;24957;499914;294515;314322;25661;361969;304929;308441;24890;29496;171142;24330;116663;25423;497840;113936;291394;29184;361239;25377;24158 zfp36;usp18;trib3;tf;slc37a4;sirt3;rrs1;psmb3;ppp1r3b;por;polg2;plg;pik3r1;pax8;parp1;jun;itih4;itih3;itih1;iars2;htra1;hspd1;hp;glul;gins1;foxo3;fos;fn1;fga;f5;exosc5;esr1;erbb3;ehhadh;egr1;dusp6;ctsc;cps1;cpb2;cndp2;cd36;bphl;ambp;acadm ZFP36_10204;USP18_10138;TRIB3_10079;TF_10003;SLC37A4_9871;SIRT3_9828;RRS1_9755;PSMB3_9589;PPP1R3B_9545;POR_9531;POLG2_9521;PLG_9501;PIK3R1_32562;PAX8_9432;PARP1_9425;JUN_8938;ITIH4_32725;ITIH3_32422;ITIH1_33132;IARS2_8858;HTRA1_8856;HSPD1_8849;HP_8823;GLUL_32832;GINS1_8707;FOXO3_8662;FOS_8657;FN1_8655;FGA_8632;F5_33079;EXOSC5_32543;ESR1_33192;ERBB3_8571;EHHADH_8534;EGR1_8533;DUSP6_8506;CTSC_32456;CPS1_32421;CPB2_8369;CNDP2_8341;CD36_8243;BPHL_8157;AMBP_33085;ACADM_7957 37.97281638636367 32.55745 1.28141E-12 27.319884476663045 41.97030180385926 25.750431855669 25.90381752272731 23.319 1.28141E-12 18.367782463259932 28.293638100903028 16.682779907164168 63.348883409090945 46.48695 1.28142E-12 43.37203373084031 70.00323407177478 41.930297110160495 0.348134;108.883;108.064;45.1539;39.7166;2.38018;60.39;23.7888;36.1411;12.4414;63.7758;70.7857;18.7324;56.8931;26.9741;16.4324;57.1163;27.1247;98.1741;24.7304;33.1323;42.2579;64.9285;26.4669;58.9165;13.1992;1.28141E-12;59.5777;28.5803;10.6089;41.9329;23.3972;60.9984;8.62809;0.750017;62.3934;56.2386;31.9826;25.8316;33.544;48.1296;12.3152;17.2343;11.7137 0.118102;73.1414;83.8836;28.132;22.6911;0.56209;43.109;19.2724;27.0588;8.48981;40.9553;46.2356;11.6701;45.1162;21.799;10.5224;39.6402;21.5108;42.9071;19.8021;25.6145;23.9469;41.6103;21.0456;44.7208;5.6804;1.28141E-12;31.0499;22.529;2.59129;31.7336;18.3088;41.6036;7.31865;0.186019;39.0875;38.2681;24.4836;20.4374;26.3005;37.5433;6.6063;14.1233;8.36151 1.15962;138.144;143.428;61.5341;60.0334;8.82917;104.942;30.901;53.6244;79.2355;132.567;150.579;41.5978;81.5688;35.2797;39.929;101.869;36.4819;104.278;32.7087;46.6629;102.383;136.455;35.4303;91.837;32.7581;1.28142E-12;105.243;38.8511;37.5078;62.1373;31.9156;113.972;10.3909;4.70178;133.304;102.888;45.5891;34.8042;46.311;69.1421;25.5051;21.9073;18.9642 17 27 17 312688;24825;293615;297784;29676;81819;25591;364070;63868;499914;308441;29496;171142;291394;29184;361239;24158 USP18_10138;TF_10003;SIRT3_9828;RRS1_9755;PSMB3_9589;PAX8_9432;PARP1_9425;IARS2_8858;HSPD1_8849;GINS1_8707;EXOSC5_32543;ERBB3_8571;EHHADH_8534;CNDP2_8341;CD36_8243;BPHL_8157;ACADM_7957 39.272339411764705 41.9329 26.23282481905076 28.18055 26.3005 18.291349695447227 60.85588647058824 61.5341 39.31906188242206 108.883;45.1539;2.38018;60.39;23.7888;56.8931;26.9741;24.7304;42.2579;58.9165;41.9329;60.9984;8.62809;33.544;48.1296;12.3152;11.7137 73.1414;28.132;0.56209;43.109;19.2724;45.1162;21.799;19.8021;23.9469;44.7208;31.7336;41.6036;7.31865;26.3005;37.5433;6.6063;8.36151 138.144;61.5341;8.82917;104.942;30.901;81.5688;35.2797;32.7087;102.383;91.837;62.1373;113.972;10.3909;46.311;69.1421;25.5051;18.9642 27 79426;246273;29573;192280;29441;303612;85253;25513;24516;54404;50693;306251;65164;24464;24957;294515;314322;25661;361969;304929;24890;24330;116663;25423;497840;113936;25377 ZFP36_10204;TRIB3_10079;SLC37A4_9871;PPP1R3B_9545;POR_9531;POLG2_9521;PLG_9501;PIK3R1_32562;JUN_8938;ITIH4_32725;ITIH3_32422;ITIH1_33132;HTRA1_8856;HP_8823;GLUL_32832;FOXO3_8662;FOS_8657;FN1_8655;FGA_8632;F5_33079;ESR1_33192;EGR1_8533;DUSP6_8506;CTSC_32456;CPS1_32421;CPB2_8369;AMBP_33085 37.154598185185236 28.5803 28.44482466050104 24.47031929629634 22.529 18.61592120187847 64.9185481481482 45.5891 46.4015644786317 0.348134;108.064;39.7166;36.1411;12.4414;63.7758;70.7857;18.7324;16.4324;57.1163;27.1247;98.1741;33.1323;64.9285;26.4669;13.1992;1.28141E-12;59.5777;28.5803;10.6089;23.3972;0.750017;62.3934;56.2386;31.9826;25.8316;17.2343 0.118102;83.8836;22.6911;27.0588;8.48981;40.9553;46.2356;11.6701;10.5224;39.6402;21.5108;42.9071;25.6145;41.6103;21.0456;5.6804;1.28141E-12;31.0499;22.529;2.59129;18.3088;0.186019;39.0875;38.2681;24.4836;20.4374;14.1233 1.15962;143.428;60.0334;53.6244;79.2355;132.567;150.579;41.5978;39.929;101.869;36.4819;104.278;46.6629;136.455;35.4303;32.7581;1.28142E-12;105.243;38.8511;37.5078;31.9156;4.70178;133.304;102.888;45.5891;34.8042;21.9073 0 Exp 2,18(0.41);Exp 3,2(0.05);Exp 4,2(0.05);Hill,5(0.12);Linear,8(0.19);Poly 2,7(0.16);Power,2(0.05) 1.928037018610284 112.00570487976074 1.5197933912277222 32.73371124267578 4.67882143707009 1.7047839164733887 29.90030638614116 46.04532638658615 20.47648463106612 31.33115041438849 50.53326640597831 76.16450041220355 DOWN 0.38636363636363635 0.6136363636363636 0.0 GO:0050766 6 positive regulation of phagocytosis 30 35 4 4 2 4 2 2 160 33 2352 0.61347 0.66341 1.0 5.71 29184;25373 cd36;ahsg CD36_8243;AHSG_8003 30.265800000000002 30.265800000000002 12.402 25.263228235520494 37.76902353410451 22.926708749284522 23.9223 23.9223 10.3013 19.26300293308393 29.643445991224574 17.481426117287736 42.2828 42.2828 15.4235 37.98478633584767 53.56434882329477 34.47168845988305 0.5 30.265800000000002 48.1296;12.402 37.5433;10.3013 69.1421;15.4235 1 1 1 29184 CD36_8243 48.1296 48.1296 37.5433 37.5433 69.1421 69.1421 48.1296 37.5433 69.1421 1 25373 AHSG_8003 12.402 12.402 10.3013 10.3013 15.4235 15.4235 12.402 10.3013 15.4235 0 Exp 2,2(1) 3.0270378093436285 6.101730823516846 2.6703107357025146 3.431420087814331 0.5381855841027651 3.050865411758423 -4.7472479999999955 65.278848 -2.774860000000004 50.619460000000004 -10.361427999999982 94.92702799999998 CONFLICT 0.5 0.5 0.0 GO:0001818 6 negative regulation of cytokine production 68 69 8 8 5 7 4 4 158 65 2320 0.55004 0.64986 1.0 5.8 79426;29573;25591;25661 zfp36;slc37a4;parp1;fn1 ZFP36_10204;SLC37A4_9871;PARP1_9425;FN1_8655 31.6541335 33.345349999999996 0.348134 24.810597536796433 40.011992783578854 20.509287763405116 18.9145255 22.24505 0.118102 13.205498333923927 23.56453540229636 9.441076442395257 50.428929999999994 47.656549999999996 1.15962 43.79418603503895 64.44658364818024 39.540135489094 2.5 49.647149999999996 0.348134;39.7166;26.9741;59.5777 0.118102;22.6911;21.799;31.0499 1.15962;60.0334;35.2797;105.243 1 3 1 25591 PARP1_9425 26.9741 26.9741 21.799 21.799 35.2797 35.2797 26.9741 21.799 35.2797 3 79426;29573;25661 ZFP36_10204;SLC37A4_9871;FN1_8655 33.21414466666667 39.7166 30.14542778198022 17.953034 22.6911 16.000968218938127 55.478673333333326 60.0334 52.19096329166701 0.348134;39.7166;59.5777 0.118102;22.6911;31.0499 1.15962;60.0334;105.243 0 Exp 2,1(0.25);Hill,1(0.25);Poly 2,1(0.25);Power,1(0.25) 1.8538201019056417 7.419664740562439 1.7792335748672485 1.9381765127182007 0.07369792616638439 1.8511273264884949 7.3397479139395045 55.968519086060496 5.97313713275455 31.855913867245448 7.510627685661824 93.34723231433816 DOWN 0.25 0.75 0.0 GO:0030307 6 positive regulation of cell growth 47 49 2 2 2 2 2 2 160 47 2338 0.3874 0.82985 0.76718 4.08 25685;25661 igfbp1;fn1 IGFBP1_32306;FN1_8655 54.3018 54.3018 49.0259 7.4612493337241865 58.308605641661494 4.853994099697704 31.8691 31.8691 31.0499 1.158523750296034 31.246954928704277 0.7536897906465189 97.20265 97.20265 89.1623 11.370772016226324 103.30892944823309 7.397375132111405 49.0259;59.5777 32.6883;31.0499 89.1623;105.243 0 2 0 2 25685;25661 IGFBP1_32306;FN1_8655 54.3018 54.3018 7.4612493337241865 31.8691 31.8691 1.158523750296034 97.20265 97.20265 11.370772016226324 49.0259;59.5777 32.6883;31.0499 89.1623;105.243 0 Exp 2,1(0.5);Power,1(0.5) 2.6531140699741944 5.735439419746399 1.7792335748672485 3.9562058448791504 1.5393518545804876 2.8677197098731995 43.961036 64.642564 30.263468000000003 33.474731999999996 81.44356400000001 112.961736 DOWN 0.0 1.0 0.0 GO:0042981 7 regulation of apoptotic process 428 455 42 42 36 37 31 31 131 424 1961 0.71105 0.36386 0.6716 6.81 79426;24794;25106;83516;29441;25513;81819;25591;24314;24567;24516;192235;63868;24471;25675;299626;25112;289388;294515;25661;361969;24360;24890;29496;24330;116663;25423;114851;246142;50559;170465 zfp36;serpina3c;rgn;ppargc1a;por;pik3r1;pax8;parp1;nqo1;mt1;jun;hyou1;hspd1;hspb1;hmgcr;gadd45b;gadd45a;g0s2;foxo3;fn1;fga;fabp1;esr1;erbb3;egr1;dusp6;ctsc;cdkn1a;bmf;acot1;acaa2 ZFP36_10204;SERPINA3C_32925;RGN_9699;PPARGC1A_33189;POR_9531;PIK3R1_32562;PAX8_9432;PARP1_9425;NQO1_33055;MT1A_9255;JUN_8938;HYOU1_8857;HSPD1_8849;HSPB1_8847;HMGCR_8810;GADD45B_8679;GADD45A_8678;G0S2_32729;FOXO3_8662;FN1_8655;FGA_8632;FABP1_33091;ESR1_33192;ERBB3_8571;EGR1_8533;DUSP6_8506;CTSC_32456;CDKN1A_8271;BMF_8152;ACOT1_7968;ACAA2_7955 42.20632616129032 33.8478 0.348134 31.153405863283194 45.577091761393675 30.283764007216966 29.453540258064518 26.2988 0.118102 22.505534900236427 32.76977759183394 23.466978139758726 67.75880322580645 62.3571 1.15962 44.983271229611006 70.24353747398624 39.201749908700926 21.5 58.2354 0.348134;29.766;77.4407;42.4094;12.4414;18.7324;56.8931;26.9741;87.2765;12.9315;16.4324;40.1982;42.2579;89.1011;1.63089;106.367;102.919;46.3784;13.1992;59.5777;28.5803;33.8478;23.3972;60.9984;0.750017;62.3934;56.2386;6.24967;94.8767;31.2018;26.5872 0.118102;23.347;58.7732;26.2988;8.48981;11.6701;45.1162;21.799;60.6992;8.91033;10.5224;29.3844;23.9469;60.3265;0.663137;52.7132;89.5012;33.7914;5.6804;31.0499;22.529;26.4736;18.3088;41.6036;0.186019;39.0875;38.2681;2.44025;73.1342;26.858;21.3695 1.15962;40.8256;89.8047;81.7305;79.2355;41.5978;81.5688;35.2797;197.117;23.4636;39.929;62.3571;102.383;106.138;7.6286;109.434;115.437;73.6529;32.7581;105.243;38.8511;46.9257;31.9156;113.972;4.70178;133.304;102.888;19.0606;109.848;37.2719;35.0407 12 19 12 25106;81819;25591;24314;63868;299626;289388;24360;29496;246142;50559;170465 RGN_9699;PAX8_9432;PARP1_9425;NQO1_33055;HSPD1_8849;GADD45B_8679;G0S2_32729;FABP1_33091;ERBB3_8571;BMF_8152;ACOT1_7968;ACAA2_7955 57.591633333333334 51.63575 27.922367203123386 40.523166666666675 37.697500000000005 17.571023418237267 86.02486666666665 85.68674999999999 46.488400405034255 77.4407;56.8931;26.9741;87.2765;42.2579;106.367;46.3784;33.8478;60.9984;94.8767;31.2018;26.5872 58.7732;45.1162;21.799;60.6992;23.9469;52.7132;33.7914;26.4736;41.6036;73.1342;26.858;21.3695 89.8047;81.5688;35.2797;197.117;102.383;109.434;73.6529;46.9257;113.972;109.848;37.2719;35.0407 19 79426;24794;83516;29441;25513;24567;24516;192235;24471;25675;25112;294515;25661;361969;24890;24330;116663;25423;114851 ZFP36_10204;SERPINA3C_32925;PPARGC1A_33189;POR_9531;PIK3R1_32562;MT1A_9255;JUN_8938;HYOU1_8857;HSPB1_8847;HMGCR_8810;GADD45A_8678;FOXO3_8662;FN1_8655;FGA_8632;ESR1_33192;EGR1_8533;DUSP6_8506;CTSC_32456;CDKN1A_8271 32.48929005263158 23.3972 29.725885902737996 22.462197263157893 18.3088 22.851799496705937 56.22234210526316 40.8256 41.09572698053704 0.348134;29.766;42.4094;12.4414;18.7324;12.9315;16.4324;40.1982;89.1011;1.63089;102.919;13.1992;59.5777;28.5803;23.3972;0.750017;62.3934;56.2386;6.24967 0.118102;23.347;26.2988;8.48981;11.6701;8.91033;10.5224;29.3844;60.3265;0.663137;89.5012;5.6804;31.0499;22.529;18.3088;0.186019;39.0875;38.2681;2.44025 1.15962;40.8256;81.7305;79.2355;41.5978;23.4636;39.929;62.3571;106.138;7.6286;115.437;32.7581;105.243;38.8511;31.9156;4.70178;133.304;102.888;19.0606 0 Exp 2,11(0.36);Exp 3,1(0.04);Exp 4,3(0.1);Hill,2(0.07);Linear,4(0.13);Poly 2,8(0.26);Power,2(0.07) 2.219144532527851 401.9062225818634 1.522104263305664 344.14306640625 61.46631045170984 1.7576230764389038 31.23950509758447 53.17314722499617 21.530998007723582 37.376082508405446 51.92350455572707 83.59410189588581 DOWN 0.3870967741935484 0.6129032258064516 0.0 GO:0042742 5 defense response to bacterium 57 66 4 4 4 4 4 4 158 62 2323 0.58867 0.61437 1.0 6.06 246074;24464;361969;29184 scd;hp;fga;cd36 SCD1_9787;HP_8823;FGA_8632;CD36_8243 61.77459999999999 56.52905 28.5803 32.69255183197952 53.91975701500572 27.895550200776555 41.35895 39.576800000000006 22.529 17.0361557851725 37.36597189623847 14.730703828853736 166.7868 102.79855 38.8511 175.41674470876492 123.18945069308931 140.08789799044607 2.5 85.19425 105.46;64.9285;28.5803;48.1296 63.7532;41.6103;22.529;37.5433 422.699;136.455;38.8511;69.1421 2 2 2 246074;29184 SCD1_9787;CD36_8243 76.7948 76.7948 40.53871460813724 50.648250000000004 50.648250000000004 18.533198024221278 245.92055 245.92055 250.0024815252941 105.46;48.1296 63.7532;37.5433 422.699;69.1421 2 24464;361969 HP_8823;FGA_8632 46.754400000000004 46.754400000000004 25.702058703924845 32.06965 32.06965 13.492516623854867 87.65305000000001 87.65305000000001 69.01637956025365 64.9285;28.5803 41.6103;22.529 136.455;38.8511 0 Exp 2,3(0.75);Linear,1(0.25) 1.9694729604380787 8.082651495933533 1.541895866394043 2.6703107357025146 0.5315965804168012 1.9352224469184875 29.735899204660093 93.81330079533993 24.663517330530944 58.05438266946906 -5.121609814589618 338.6952098145896 CONFLICT 0.5 0.5 0.0 GO:2001257 7 regulation of cation channel activity 35 35 4 3 3 3 3 3 159 32 2353 0.82057 0.38653 0.48519 8.57 362895;83516;81869 stac3;ppargc1a;gstm7 STAC3_9953;PPARGC1A_33189;GSTM7_8761 49.3213 42.4094 42.3152 12.053433594208755 49.39157539032989 12.081585346111032 33.468466666666664 31.4035 26.2988 8.394839493601602 33.43327947620247 8.477910008155533 89.28320000000001 81.7305 64.5991 29.20239154880983 89.71376760891464 29.032300928646784 0.5 42.3623 63.2393;42.4094;42.3152 42.7031;26.2988;31.4035 121.52;81.7305;64.5991 1 2 1 81869 GSTM7_8761 42.3152 42.3152 31.4035 31.4035 64.5991 64.5991 42.3152 31.4035 64.5991 2 362895;83516 STAC3_9953;PPARGC1A_33189 52.824349999999995 52.824349999999995 14.728963541437698 34.50095 34.50095 11.599591770618453 101.62525 101.62525 28.135425270022225 63.2393;42.4094 42.7031;26.2988 121.52;81.7305 0 Exp 2,1(0.34);Linear,2(0.67) 2.068975609078652 6.386926651000977 1.7501527070999146 2.879150867462158 0.6496816192768183 1.7576230764389038 35.68155586465962 62.961044135340366 23.968811497454872 42.96812183587847 56.237583101495034 122.32881689850495 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0015722 7 canalicular bile acid transport 4 4 3 3 3 3 3 3 159 1 2384 0.99998 9.6404E-4 9.6404E-4 75.0 65054;140668;25303 aqp9;abcc3;abcc2 AQP9_32709;ABCC3_7941;ABCC2_32541 37.2269 37.7175 27.7316 9.259752495072437 39.13237664461248 7.74842076513088 28.005566666666667 30.9007 21.9372 5.2571989122852685 29.54518617202269 4.104087543835262 56.06006666666667 48.9329 37.4625 23.00465056990288 58.78381587901702 21.53207199669825 0.0 27.7316 0.0 27.7316 27.7316;37.7175;46.2316 21.9372;30.9007;31.1788 37.4625;48.9329;81.7848 1 2 1 140668 ABCC3_7941 37.7175 37.7175 30.9007 30.9007 48.9329 48.9329 37.7175 30.9007 48.9329 2 65054;25303 AQP9_32709;ABCC2_32541 36.9816 36.9816 13.08147545195113 26.558 26.558 6.534798029013595 59.62365 59.62365 31.340598887784523 27.7316;46.2316 21.9372;31.1788 37.4625;81.7848 0 Exp 2,2(0.67);Linear,1(0.34) 2.1731443872987293 6.714246153831482 1.8171201944351196 3.0381598472595215 0.6932035270575799 1.8589661121368408 26.748503632507628 47.70529636749237 22.056486060571714 33.95464727276162 30.027853916339105 82.09227941699422 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0043406 9 positive regulation of MAP kinase activity 68 75 4 4 4 4 4 4 158 71 2314 0.47504 0.71416 1.0 5.33 24825;29455;299626;25112 tf;gdf15;gadd45b;gadd45a TF_10003;GDF15_33113;GADD45B_8679;GADD45A_8678 89.897225 104.03399999999999 45.1539 29.86303113331204 87.61844061848228 30.64703723024728 63.92377499999999 69.03094999999999 28.132 28.982524794362458 68.19512700144394 30.867268430178747 103.014275 112.43549999999999 61.5341 28.45234891713688 102.74168319829937 30.254663031488562 2.5 105.75800000000001 45.1539;105.149;106.367;102.919 28.132;85.3487;52.7132;89.5012 61.5341;125.652;109.434;115.437 2 2 2 24825;299626 TF_10003;GADD45B_8679 75.76045 75.76045 43.28419810745022 40.4226 40.4226 17.38153320970276 85.48405 85.48405 33.8703441081575 45.1539;106.367 28.132;52.7132 61.5341;109.434 2 29455;25112 GDF15_33113;GADD45A_8678 104.03399999999999 104.03399999999999 1.5768481220472597 87.42495 87.42495 2.936260908877124 120.5445 120.5445 7.223095769820622 105.149;102.919 85.3487;89.5012 125.652;115.437 0 Poly 2,3(0.75);Power,1(0.25) 1.6416678783131047 6.581766247749329 1.5527137517929077 1.8344712257385254 0.1312217932682175 1.5972906351089478 60.63145448935416 119.16299551064586 35.52090070152481 92.32664929847517 75.13097306120586 130.89757693879415 CONFLICT 0.5 0.5 0.0 GO:1903829 6 positive regulation of cellular protein localization 83 90 6 5 4 5 4 4 158 86 2299 0.31087 0.83639 0.65783 4.44 362895;25513;25591;290556 stac3;pik3r1;parp1;gnl3 STAC3_9953;PIK3R1_32562;PARP1_9425;GNL3_8735 49.145375 45.106700000000004 18.7324 32.128172081977624 40.61372135556444 25.210754783846102 32.64555 32.25105 11.6701 19.42903965211181 28.503382624336208 15.464249027826149 109.340125 81.5589 35.2797 94.91120100014099 76.54223007480157 67.11186840462257 63.2393;18.7324;26.9741;87.6357 42.7031;11.6701;21.799;54.41 121.52;41.5978;35.2797;238.963 2 2 2 25591;290556 PARP1_9425;GNL3_8735 57.3049 57.3049 42.89422871762586 38.1045 38.1045 23.059459241274496 137.12135 137.12135 144.0258426444539 26.9741;87.6357 21.799;54.41 35.2797;238.963 2 362895;25513 STAC3_9953;PIK3R1_32562 40.98585 40.98585 31.47113079959156 27.1866 27.1866 21.94364474056213 81.5589 81.5589 56.5135295873475 63.2393;18.7324 42.7031;11.6701 121.52;41.5978 0 Exp 2,2(0.5);Linear,1(0.25);Poly 2,1(0.25) 1.9271050679000064 7.943928599357605 1.582527995109558 2.879150867462158 0.6026498138831701 1.7411248683929443 17.65976635966193 80.63098364033807 13.60509114093042 51.68600885906958 16.327148019861824 202.35310198013818 CONFLICT 0.5 0.5 0.0 GO:0000288 9 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay 1 1 1 1 1 1 1 1 161 0 2385 1.0 0.063604 0.063604 100.0 79426 zfp36 ZFP36_10204 0.348134 0.348134 0.348134 0.348134 0.118102 0.118102 0.118102 0.118102 1.15962 1.15962 1.15962 1.1596200000000003 0.0 0.348134 0.0 0.348134 0.348134 0.118102 1.15962 0 1 0 1 79426 ZFP36_10204 0.348134 0.348134 0.118102 0.118102 1.15962 1.15962 0.348134 0.118102 1.15962 0 Hill,1(1) 1.9381765127182007 1.9381765127182007 1.9381765127182007 1.9381765127182007 0.0 1.9381765127182007 0.348134 0.348134 0.118102 0.118102 1.15962 1.15962 DOWN 0.0 1.0 0.0 GO:0031086 9 nuclear-transcribed mRNA catabolic process, deadenylation-independent decay 1 1 1 1 1 1 1 1 161 0 2385 1.0 0.063604 0.063604 100.0 79426 zfp36 ZFP36_10204 0.348134 0.348134 0.348134 0.348134 0.118102 0.118102 0.118102 0.118102 1.15962 1.15962 1.15962 1.1596200000000003 0.0 0.348134 0.0 0.348134 0.348134 0.118102 1.15962 0 1 0 1 79426 ZFP36_10204 0.348134 0.348134 0.118102 0.118102 1.15962 1.15962 0.348134 0.118102 1.15962 0 Hill,1(1) 1.9381765127182007 1.9381765127182007 1.9381765127182007 1.9381765127182007 0.0 1.9381765127182007 0.348134 0.348134 0.118102 0.118102 1.15962 1.15962 DOWN 0.0 1.0 0.0 GO:1901835 9 positive regulation of deadenylation-independent decapping of nuclear-transcribed mRNA 1 1 1 1 1 1 1 1 161 0 2385 1.0 0.063604 0.063604 100.0 79426 zfp36 ZFP36_10204 0.348134 0.348134 0.348134 0.348134 0.118102 0.118102 0.118102 0.118102 1.15962 1.15962 1.15962 1.1596200000000003 0.0 0.348134 0.0 0.348134 0.348134 0.118102 1.15962 0 1 0 1 79426 ZFP36_10204 0.348134 0.348134 0.118102 0.118102 1.15962 1.15962 0.348134 0.118102 1.15962 0 Hill,1(1) 1.9381765127182007 1.9381765127182007 1.9381765127182007 1.9381765127182007 0.0 1.9381765127182007 0.348134 0.348134 0.118102 0.118102 1.15962 1.15962 DOWN 0.0 1.0 0.0 GO:1902172 9 regulation of keratinocyte apoptotic process 1 1 1 1 1 1 1 1 161 0 2385 1.0 0.063604 0.063604 100.0 79426 zfp36 ZFP36_10204 0.348134 0.348134 0.348134 0.348134 0.118102 0.118102 0.118102 0.118102 1.15962 1.15962 1.15962 1.1596200000000003 0.0 0.348134 0.0 0.348134 0.348134 0.118102 1.15962 0 1 0 1 79426 ZFP36_10204 0.348134 0.348134 0.118102 0.118102 1.15962 1.15962 0.348134 0.118102 1.15962 0 Hill,1(1) 1.9381765127182007 1.9381765127182007 1.9381765127182007 1.9381765127182007 0.0 1.9381765127182007 0.348134 0.348134 0.118102 0.118102 1.15962 1.15962 DOWN 0.0 1.0 0.0 GO:0007165 4 signal transduction 714 752 53 53 42 45 36 36 126 716 1669 0.019941 0.98755 0.040273 4.79 79426;24856;246273;24825;362895;170698;308821;25513;25591;81525;25493;24567;24539;58954;24516;81678;25685;63868;24471;24464;25675;29455;25112;289388;294515;314322;24890;29496;116636;24330;140942;25428;170945;114851;29184;25303 zfp36;ttr;trib3;tf;stac3;slco1a2;rab30;pik3r1;parp1;nfkbib;nfkbia;mt1;lpl;klf6;jun;itpr2;igfbp1;hspd1;hspb1;hp;hmgcr;gdf15;gadd45a;g0s2;foxo3;fos;esr1;erbb3;eif4ebp1;egr1;ddit4;cyp7a1;chrna2;cdkn1a;cd36;abcc2 ZFP36_10204;TTR_10102;TRIB3_10079;TF_10003;STAC3_9953;SLCO1A2_9886;RAB30_9639;PIK3R1_32562;PARP1_9425;NFKBIB_9308;NFKBIA_9307;MT1A_9255;LPL_32544;KLF6_8969;JUN_8938;ITPR2_8931;IGFBP1_32306;HSPD1_8849;HSPB1_8847;HP_8823;HMGCR_8810;GDF15_33113;GADD45A_8678;G0S2_32729;FOXO3_8662;FOS_8657;ESR1_33192;ERBB3_8571;EIF4EBP1_8550;EGR1_8533;DDIT4_8450;CYP7A1_8430;CHRNA2_32401;CDKN1A_8271;CD36_8243;ABCC2_32541 43.11319283333337 43.7059 1.28141E-12 33.85502576331432 48.80898238905822 31.700714158653224 30.32412536111115 26.433100000000003 1.28141E-12 25.747939420665116 34.89177363310457 24.763455811990813 70.34259972222226 62.00305 1.28142E-12 54.473988770590495 75.961332014727 47.9828573534436 0.348134;46.6406;108.064;45.1539;63.2393;104.197;26.4203;18.7324;26.9741;30.5572;0.520151;12.9315;74.2041;18.9476;16.4324;31.8111;49.0259;42.2579;89.1011;64.9285;1.63089;105.149;102.919;46.3784;13.1992;1.28141E-12;23.3972;60.9984;83.9001;0.750017;87.5421;5.72128;49.3913;6.24967;48.1296;46.2316 0.118102;28.5876;83.8836;28.132;42.7031;80.3101;21.0125;11.6701;21.799;24.2439;0.160202;8.91033;49.8682;11.6941;10.5224;24.7342;32.6883;23.9469;60.3265;41.6103;0.663137;85.3487;89.5012;33.7914;5.6804;1.28141E-12;18.3088;41.6036;42.4185;0.186019;53.2453;0.985273;41.8524;2.44025;37.5433;31.1788 1.15962;63.7146;143.428;61.5341;121.52;128.412;35.3561;41.5978;35.2797;41.2611;2.88499;23.4636;155.425;45.5481;39.929;44.3296;89.1623;102.383;106.138;136.455;7.6286;125.652;115.437;73.6529;32.7581;1.28142E-12;31.9156;113.972;107.32;4.70178;245.492;22.3625;62.472;19.0606;69.1421;81.7848 12 24 12 24856;24825;308821;25591;81525;24539;63868;289388;29496;116636;170945;29184 TTR_10102;TF_10003;RAB30_9639;PARP1_9425;NFKBIB_9308;LPL_32544;HSPD1_8849;G0S2_32729;ERBB3_8571;EIF4EBP1_8550;CHRNA2_32401;CD36_8243 48.41715833333333 46.5095 17.585808962727885 32.89994166666667 31.189500000000002 9.61880800992215 76.79271666666665 66.42835 36.34714955028261 46.6406;45.1539;26.4203;26.9741;30.5572;74.2041;42.2579;46.3784;60.9984;83.9001;49.3913;48.1296 28.5876;28.132;21.0125;21.799;24.2439;49.8682;23.9469;33.7914;41.6036;42.4185;41.8524;37.5433 63.7146;61.5341;35.3561;35.2797;41.2611;155.425;102.383;73.6529;113.972;107.32;62.472;69.1421 24 79426;246273;362895;170698;25513;25493;24567;58954;24516;81678;25685;24471;24464;25675;29455;25112;294515;314322;24890;24330;140942;25428;114851;25303 ZFP36_10204;TRIB3_10079;STAC3_9953;SLCO1A2_9886;PIK3R1_32562;NFKBIA_9307;MT1A_9255;KLF6_8969;JUN_8938;ITPR2_8931;IGFBP1_32306;HSPB1_8847;HP_8823;HMGCR_8810;GDF15_33113;GADD45A_8678;FOXO3_8662;FOS_8657;ESR1_33192;EGR1_8533;DDIT4_8450;CYP7A1_8430;CDKN1A_8271;ABCC2_32541 40.461210083333384 21.172400000000003 39.676656472995994 29.036217208333387 15.001450000000002 30.97426026627655 67.11754125000006 42.9637 62.058317804535896 0.348134;108.064;63.2393;104.197;18.7324;0.520151;12.9315;18.9476;16.4324;31.8111;49.0259;89.1011;64.9285;1.63089;105.149;102.919;13.1992;1.28141E-12;23.3972;0.750017;87.5421;5.72128;6.24967;46.2316 0.118102;83.8836;42.7031;80.3101;11.6701;0.160202;8.91033;11.6941;10.5224;24.7342;32.6883;60.3265;41.6103;0.663137;85.3487;89.5012;5.6804;1.28141E-12;18.3088;0.186019;53.2453;0.985273;2.44025;31.1788 1.15962;143.428;121.52;128.412;41.5978;2.88499;23.4636;45.5481;39.929;44.3296;89.1623;106.138;136.455;7.6286;125.652;115.437;32.7581;1.28142E-12;31.9156;4.70178;245.492;22.3625;19.0606;81.7848 0 Exp 2,9(0.25);Exp 3,2(0.06);Exp 4,4(0.12);Hill,4(0.12);Linear,6(0.17);Poly 2,11(0.31) 2.0273270903698215 76.4320387840271 1.522104263305664 4.560328960418701 0.7530854808966755 1.8680511713027954 32.053884417317356 54.172501249349374 21.913131817027207 38.73511890519509 52.547763390496044 88.1374360539485 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0016999 5 antibiotic metabolic process 46 51 11 11 7 9 5 5 157 46 2339 0.89848 0.22108 0.25492 9.8 286954;360268;25146;65183;25303 ugt2b1;sult1e1;cyp17a1;aldh3a2;abcc2 UGT2B10_33303,UGT2B1_33224;SULT1E1_32446;CYP17A1_32365;ALDH3A2_8024;ABCC2_32541 47.33795 47.47345 43.1079 2.862761030019757 46.90936179923686 2.8434960609404873 34.010329999999996 34.82915 31.1788 2.3547618960311327 33.932847820174146 2.206829010763987 77.43701000000001 80.9788 66.3058 6.594505777387596 76.05905139321007 6.726410573632048 1.5 46.852525 47.47345;50.1846;49.6922;43.1079;46.2316 34.82915;36.5009;35.6654;31.8774;31.1788 76.47475;80.9788;81.6409;66.3058;81.7848 5 1 4 286954;360268;25146;65183 UGT2B10_33303,UGT2B1_33224;SULT1E1_32446;CYP17A1_32365;ALDH3A2_8024 47.6145375 48.582825 3.2275682258152742 34.7182125 35.247275 2.0130955989780888 76.3500625 78.726775 7.078628125959506 47.47345;50.1846;49.6922;43.1079 34.82915;36.5009;35.6654;31.8774 76.47475;80.9788;81.6409;66.3058 1 25303 ABCC2_32541 46.2316 46.2316 31.1788 31.1788 81.7848 81.7848 46.2316 31.1788 81.7848 0 Exp 2,4(0.67);Linear,2(0.34) 1.7356737737200172 10.443967938423157 1.520427942276001 1.90940523147583 0.14265622097431194 1.756584882736206 44.82862931954707 49.847270680452944 31.946290193222076 36.074369806777916 71.65667082706842 83.21734917293158 UP 0.8 0.2 0.0 GO:0072331 6 signal transduction by p53 class mediator 28 29 4 4 4 3 3 3 159 26 2359 0.8916 0.27947 0.42657 10.34 294515;140942;114851 foxo3;ddit4;cdkn1a FOXO3_8662;DDIT4_8450;CDKN1A_8271 35.66365666666667 13.1992 6.24967 45.06221980576005 19.496117195170072 35.27356311246762 20.455316666666665 5.6804 2.44025 28.44313446608572 10.565358527345909 22.090805173955275 99.10356666666667 32.7581 19.0606 126.96096028663035 55.16969889511482 98.49060978686045 0.5 9.724435 1.5 50.370650000000005 13.1992;87.5421;6.24967 5.6804;53.2453;2.44025 32.7581;245.492;19.0606 0 3 0 3 294515;140942;114851 FOXO3_8662;DDIT4_8450;CDKN1A_8271 35.66365666666667 13.1992 45.06221980576005 20.455316666666665 5.6804 28.44313446608572 99.10356666666667 32.7581 126.96096028663035 13.1992;87.5421;6.24967 5.6804;53.2453;2.44025 32.7581;245.492;19.0606 0 Exp 4,2(0.67);Linear,1(0.34) 1.7151776842204762 5.177662134170532 1.522104263305664 1.9883413314819336 0.23859159963927015 1.6672165393829346 -15.329045414203122 86.65635874753646 -11.731119960892308 52.641753294225644 -44.56628474552983 242.77341807886316 DOWN 0.0 1.0 0.0 GO:1900407 6 regulation of cellular response to oxidative stress 37 41 7 7 6 7 6 6 156 35 2350 0.98677 0.042466 0.042466 14.63 293615;25106;25591;24471;294515;29184 sirt3;rgn;parp1;hspb1;foxo3;cd36 SIRT3_9828;RGN_9699;PARP1_9425;HSPB1_8847;FOXO3_8662;CD36_8243 42.87081333333333 37.55185 2.38018 35.02162996484698 47.486790619245454 33.02325103186024 30.780748333333335 29.67115 0.56209 25.791965795371564 34.77117940742197 23.47223822166556 56.99196166666667 52.210899999999995 8.82917 37.464627587632805 61.5462052332697 36.439906748429486 1.5 20.08665 3.5 62.78515 2.38018;77.4407;26.9741;89.1011;13.1992;48.1296 0.56209;58.7732;21.799;60.3265;5.6804;37.5433 8.82917;89.8047;35.2797;106.138;32.7581;69.1421 4 2 4 293615;25106;25591;29184 SIRT3_9828;RGN_9699;PARP1_9425;CD36_8243 38.731145 37.55185 31.866290278015853 29.669397500000002 29.67115 24.618476579228563 50.7639175 52.210899999999995 35.871178447753266 2.38018;77.4407;26.9741;48.1296 0.56209;58.7732;21.799;37.5433 8.82917;89.8047;35.2797;69.1421 2 24471;294515 HSPB1_8847;FOXO3_8662 51.150150000000004 51.150150000000004 53.67074819494321 33.00345 33.00345 38.640627875398195 69.44805 69.44805 51.88742489279077 89.1011;13.1992 60.3265;5.6804 106.138;32.7581 0 Exp 2,2(0.34);Exp 4,1(0.17);Hill,1(0.17);Poly 2,2(0.34) 1.8691007033532379 11.405498147010803 1.5209722518920898 2.6703107357025146 0.40662072138512056 1.7642781138420105 14.847673031016061 70.89395363565062 10.142877483754106 51.418619182912565 27.01401614225458 86.96990719107876 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0000186 10 activation of MAPKK activity 11 12 1 1 1 1 1 1 161 11 2374 0.82518 0.54632 0.54632 8.33 299626 gadd45b GADD45B_8679 106.367 106.367 106.367 106.367 52.7132 52.7132 52.7132 52.7132 109.434 109.434 109.434 109.434 0.0 106.367 106.367 52.7132 109.434 1 0 1 299626 GADD45B_8679 106.367 106.367 52.7132 52.7132 109.434 109.434 106.367 52.7132 109.434 0 0 Power,1(1) 1.5527137517929077 1.5527137517929077 1.5527137517929077 1.5527137517929077 0.0 1.5527137517929077 106.367 106.367 52.7132 52.7132 109.434 109.434 UP 1.0 0.0 0.0 GO:0002252 3 immune effector process 125 137 8 7 6 6 5 5 157 132 2253 0.11912 0.94528 0.21046 3.65 63868;308441;140942;25423;313421 hspd1;exosc5;ddit4;ctsc;c8b HSPD1_8849;EXOSC5_32543;DDIT4_8450;CTSC_32456;C8B_8181 49.866659999999996 42.2579 21.3618 24.461220424643596 47.95900661457828 19.653561768659248 32.880539999999996 31.7336 17.2088 13.878743479256332 31.27818618848879 11.957049251628018 108.16327999999999 102.383 27.9161 82.88307771449492 100.29022790449383 61.022139043250625 42.2579;41.9329;87.5421;56.2386;21.3618 23.9469;31.7336;53.2453;38.2681;17.2088 102.383;62.1373;245.492;102.888;27.9161 2 3 2 63868;308441 HSPD1_8849;EXOSC5_32543 42.0954 42.0954 0.22980970388578625 27.840249999999997 27.840249999999997 5.506028373065281 82.26015 82.26015 28.45800738359944 42.2579;41.9329 23.9469;31.7336 102.383;62.1373 3 140942;25423;313421 DDIT4_8450;CTSC_32456;C8B_8181 55.04749999999999 56.2386 33.106223983263334 36.24073333333333 38.2681 18.10359065940603 125.43203333333334 102.888 110.52598402368254 87.5421;56.2386;21.3618 53.2453;38.2681;17.2088 245.492;102.888;27.9161 0 Exp 2,3(0.6);Exp 3,1(0.2);Linear,1(0.2) 1.7018685116095662 8.602930307388306 1.5122476816177368 2.2518506050109863 0.302126481579412 1.5979743003845215 28.425454940613147 71.30786505938684 20.715284966135556 45.04579503386444 35.513059186028684 180.8135008139713 DOWN 0.4 0.6 0.0 GO:0046394 6 carboxylic acid biosynthetic process 88 95 20 20 14 16 10 10 152 85 2300 0.96398 0.076147 0.12757 10.53 65192;246074;25106;24651;24539;24957;25428;25698;25284;296925 slc27a2;scd;rgn;pklr;lpl;glul;cyp7a1;ass1;amacr;aass SLC27A2_9860;SCD1_9787;RGN_9699;PKLR_9489;LPL_32544;GLUL_32832;CYP7A1_8430;ASS1_33159;AMACR_8038;AASS_7936 37.631701 26.6353 2.03774 35.37940232274846 40.23049717201671 33.815875033458866 26.128443300000004 21.01405 0.985273 23.267491550317768 28.333903188057228 22.14517987932988 84.953231 36.0692 3.73641 126.70106881655845 84.13691573607287 113.68922883408155 3.5 24.781599999999997 8.5 91.45035 7.62189;105.46;77.4407;23.0963;74.2041;26.4669;5.72128;26.8037;2.03774;27.4644 5.49916;63.7532;58.7732;17.4625;49.8682;21.0456;0.985273;20.9825;1.165;21.7498 13.3925;422.699;89.8047;32.9443;155.425;35.4303;22.3625;36.7081;3.73641;37.0295 6 4 6 65192;246074;25106;24539;25284;296925 SLC27A2_9860;SCD1_9787;RGN_9699;LPL_32544;AMACR_8038;AASS_7936 49.038138333333336 50.83425 42.45757144478445 33.468093333333336 35.809 27.530234569481365 120.34785166666666 63.4171 158.46711371738056 7.62189;105.46;77.4407;74.2041;2.03774;27.4644 5.49916;63.7532;58.7732;49.8682;1.165;21.7498 13.3925;422.699;89.8047;155.425;3.73641;37.0295 4 24651;24957;25428;25698 PKLR_9489;GLUL_32832;CYP7A1_8430;ASS1_33159 20.522045 24.781599999999997 10.008162067371149 15.11896825 19.2225 9.570082740264002 31.8613 34.1873 6.5225077406367875 23.0963;26.4669;5.72128;26.8037 17.4625;21.0456;0.985273;20.9825 32.9443;35.4303;22.3625;36.7081 0 Exp 2,4(0.4);Exp 4,1(0.1);Hill,2(0.2);Linear,2(0.2);Poly 2,1(0.1) 2.1548467742457698 22.692617654800415 1.559399127960205 4.560328960418701 0.8832129044683428 2.056761085987091 15.703320255314004 59.560081744685995 11.707102627405629 40.54978397259438 6.423094950140381 163.48336704985962 UP 0.6 0.4 0.0 GO:0010801 10 negative regulation of peptidyl-threonine phosphorylation 4 5 1 1 1 1 1 1 161 4 2381 0.9646 0.28025 0.28025 20.0 140942 ddit4 DDIT4_8450 87.5421 87.5421 87.5421 87.5421 53.2453 53.2453 53.2453 53.2453 245.492 245.492 245.492 245.49199999999996 0.0 87.5421 0.0 87.5421 87.5421 53.2453 245.492 0 1 0 1 140942 DDIT4_8450 87.5421 87.5421 53.2453 53.2453 245.492 245.492 87.5421 53.2453 245.492 0 Linear,1(1) 1.6672165393829346 1.6672165393829346 1.6672165393829346 1.6672165393829346 0.0 1.6672165393829346 87.5421 87.5421 53.2453 53.2453 245.492 245.492 DOWN 0.0 1.0 0.0 GO:0008306 7 associative learning 20 22 2 2 2 2 2 2 160 20 2365 0.83934 0.41295 0.64706 9.09 25675;314322 hmgcr;fos HMGCR_8810;FOS_8657 0.8154450000006407 0.8154450000006407 1.28141E-12 1.1532133783684224 0.5172907436628468 1.0733634868502022 0.3315685000006407 0.3315685000006407 1.28141E-12 0.46890866955479743 0.2103358484515792 0.43644086515863506 3.8143000000006406 3.8143000000006406 1.28142E-12 5.39423479095879 2.4196629859163683 5.0207314385338755 0.5 0.8154450000006407 1.63089;1.28141E-12 0.663137;1.28141E-12 7.6286;1.28142E-12 0 2 0 2 25675;314322 HMGCR_8810;FOS_8657 0.8154450000006407 0.8154450000006407 1.1532133783684224 0.3315685000006407 0.3315685000006407 0.46890866955479743 3.8143000000006406 3.8143000000006406 5.39423479095879 1.63089;1.28141E-12 0.663137;1.28141E-12 7.6286;1.28142E-12 0 Exp 4,1(0.5);Hill,1(0.5) 1.8992174421344263 3.798438310623169 1.8966681957244873 1.9017701148986816 0.0036076016451384854 1.8992191553115845 -0.7828271999981035 2.4137171999993847 -0.31830575999810334 0.9814427599993847 -3.661727999998102 11.290327999999384 DOWN 0.0 1.0 0.0 GO:0019439 5 aromatic compound catabolic process 57 68 8 8 7 7 6 6 156 62 2323 0.86236 0.26196 0.44302 8.82 79426;286954;24443;308441;65030;25315 zfp36;ugt2b1;hdc;exosc5;ephx2;ephx1 ZFP36_10204;UGT2B10_33303,UGT2B1_33224;HDC_8788;EXOSC5_32543;EPHX2_33282;EPHX1_8567 27.588830666666667 31.6519 0.348134 18.46531428435711 29.868198044594106 18.58004282432545 20.659467 25.135800000000003 0.118102 14.178114621083227 21.605963589483093 14.511794199507365 41.657828333333335 43.24565 1.15962 28.248579760370546 47.438213558777086 28.200415039048387 2.5 31.6519 0.348134;47.47345;24.5745;41.9329;38.7293;12.4747 0.118102;34.82915;21.0619;31.7336;29.2097;7.00435 1.15962;76.47475;29.28;62.1373;57.2113;23.684 6 1 5 286954;24443;308441;65030;25315 UGT2B10_33303,UGT2B1_33224;HDC_8788;EXOSC5_32543;EPHX2_33282;EPHX1_8567 33.03697 38.7293 14.268606205915844 24.76774 29.2097 11.166439223931235 49.75747 57.2113 22.48213423219647 47.47345;24.5745;41.9329;38.7293;12.4747 34.82915;21.0619;31.7336;29.2097;7.00435 76.47475;29.28;62.1373;57.2113;23.684 1 79426 ZFP36_10204 0.348134 0.348134 0.118102 0.118102 1.15962 1.15962 0.348134 0.118102 1.15962 0 Exp 2,4(0.58);Hill,2(0.29);Linear,1(0.15) 2.9160241500324364 31.5524959564209 1.5979743003845215 17.513065338134766 5.833395498432049 1.9381765127182007 12.813502007311861 42.36415932602148 9.31461253012646 32.00432146987354 19.054256918734755 64.26139974793192 UP 0.8333333333333334 0.16666666666666666 0.0 GO:0009267 5 cellular response to starvation 53 55 9 9 7 7 5 5 157 50 2335 0.86674 0.26977 0.39453 9.09 24516;24957;294515;114851;246142 jun;glul;foxo3;cdkn1a;bmf JUN_8938;GLUL_32832;FOXO3_8662;CDKN1A_8271;BMF_8152 31.444974000000002 16.4324 6.24967 36.19894361271306 41.13678254674473 43.69368390651548 22.56457 10.5224 2.44025 29.131907157608136 30.497511062621967 34.834290947298356 47.4052 35.4303 19.0606 35.764329141827886 55.864943288983504 44.02463492069043 1.5 14.8158 16.4324;26.4669;13.1992;6.24967;94.8767 10.5224;21.0456;5.6804;2.44025;73.1342 39.929;35.4303;32.7581;19.0606;109.848 1 4 1 246142 BMF_8152 94.8767 94.8767 73.1342 73.1342 109.848 109.848 94.8767 73.1342 109.848 4 24516;24957;294515;114851 JUN_8938;GLUL_32832;FOXO3_8662;CDKN1A_8271 15.587042499999999 14.8158 8.405836177554955 9.922162499999999 8.1014 8.125324827083839 31.7945 34.0942 8.990177344561493 16.4324;26.4669;13.1992;6.24967 10.5224;21.0456;5.6804;2.44025 39.929;35.4303;32.7581;19.0606 0 Exp 4,2(0.4);Linear,1(0.2);Poly 2,2(0.4) 1.889166498844341 9.552395224571228 1.522104263305664 2.3622660636901855 0.31993894314389504 1.9785058498382568 -0.2847990636296238 63.174747063629624 -2.9706724897007923 48.099812489700795 16.056383316724883 78.75401668327513 DOWN 0.2 0.8 0.0 GO:0046272 6 stilbene catabolic process 1 1 1 1 1 1 1 1 161 0 2385 1.0 0.063604 0.063604 100.0 65030 ephx2 EPHX2_33282 38.7293 38.7293 38.7293 38.7293 29.2097 29.2097 29.2097 29.209699999999998 57.2113 57.2113 57.2113 57.2113 0.0 38.7293 0.0 38.7293 38.7293 29.2097 57.2113 1 0 1 65030 EPHX2_33282 38.7293 38.7293 29.2097 29.2097 57.2113 57.2113 38.7293 29.2097 57.2113 0 0 Linear,1(1) 4.642963409423827 4.642963409423828 4.642963409423828 4.642963409423828 0.0 4.642963409423828 38.7293 38.7293 29.2097 29.2097 57.2113 57.2113 UP 1.0 0.0 0.0 GO:0009892 5 negative regulation of metabolic process 589 626 65 65 54 59 49 49 113 577 1808 0.96389 0.052942 0.089618 7.83 79426;24522;246273;29573;293615;79224;24794;24648;25106;252922;83516;29441;25513;25591;299282;288001;24516;54404;50693;306251;63868;24471;24464;25675;299626;25112;294515;25661;83928;24360;308441;24890;116636;24330;116663;140942;25428;65210;113936;25695;114851;29184;246142;79431;155423;25377;25373;25287;25303 zfp36;zfp354a;trib3;slc37a4;sirt3;serpind1;serpina3c;serpina1;rgn;pzp;ppargc1a;por;pik3r1;parp1;loc299282;kng1;jun;itih4;itih3;itih1;hspd1;hspb1;hp;hmgcr;gadd45b;gadd45a;foxo3;fn1;fetub;fabp1;exosc5;esr1;eif4ebp1;egr1;dusp6;ddit4;cyp7a1;cyp2j4;cpb2;cebpd;cdkn1a;cd36;bmf;bhlhe40;anxa7;ambp;ahsg;acadl;abcc2 ZFP36_10204;ZFP354A_10203;TRIB3_10079;SLC37A4_9871;SIRT3_9828;SERPIND1_9812;SERPINA3C_32925;SERPINA1_9807;RGN_9699;PZP_9633;PPARGC1A_33189;POR_9531;PIK3R1_32562;PARP1_9425;LOC299282_9119;KNG1L1_34113;JUN_8938;ITIH4_32725;ITIH3_32422;ITIH1_33132;HSPD1_8849;HSPB1_8847;HP_8823;HMGCR_8810;GADD45B_8679;GADD45A_8678;FOXO3_8662;FN1_8655;FETUB_33027;FABP1_33091;EXOSC5_32543;ESR1_33192;EIF4EBP1_8550;EGR1_8533;DUSP6_8506;DDIT4_8450;CYP7A1_8430;CYP2J4_32580;CPB2_8369;CEBPD_8283;CDKN1A_8271;CD36_8243;BMF_8152;BHLHE40_8141;ANXA7_8051;AMBP_33085;AHSG_8003;ACADL_32776;ABCC2_32541 41.28137416326531 33.4878 0.306936 32.751543034888115 45.629675493023406 33.561091380644584 27.238729902040813 23.347 0.0732342 21.576239290016765 30.102130708703495 23.246073961657757 64.19616795918367 48.5666 1.15962 48.64455976269263 68.9308565124893 44.81635406444907 30.5 43.80555 0.348134;0.834827;108.064;39.7166;2.38018;28.261;29.766;15.797;77.4407;34.1871;42.4094;12.4414;18.7324;26.9741;45.2017;24.3655;16.4324;57.1163;27.1247;98.1741;42.2579;89.1011;64.9285;1.63089;106.367;102.919;13.1992;59.5777;32.5155;33.8478;41.9329;23.3972;83.9001;0.750017;62.3934;87.5421;5.72128;17.8395;25.8316;0.306936;6.24967;48.1296;94.8767;57.8085;104.64;17.2343;12.402;33.4878;46.2316 0.118102;0.27095;83.8836;22.6911;0.56209;22.307;23.347;13.013;58.7732;26.3085;26.2988;8.48981;11.6701;21.799;30.7472;19.538;10.5224;39.6402;21.5108;42.9071;23.9469;60.3265;41.6103;0.663137;52.7132;89.5012;5.6804;31.0499;19.6094;26.4736;31.7336;18.3088;42.4185;0.186019;39.0875;53.2453;0.985273;14.6501;20.4374;0.0732342;2.44025;37.5433;73.1342;38.3491;43.9254;14.1233;10.3013;26.6039;31.1788 1.15962;2.99857;143.428;60.0334;8.82917;38.3264;40.8256;19.9134;89.8047;48.5666;81.7305;79.2355;41.5978;35.2797;78.6415;32.1467;39.929;101.869;36.4819;104.278;102.383;106.138;136.455;7.6286;109.434;115.437;32.7581;105.243;49.9875;46.9257;62.1373;31.9156;107.32;4.70178;133.304;245.492;22.3625;22.6149;34.8042;1.73689;19.0606;69.1421;109.848;110.58;108.689;21.9073;15.4235;45.3228;81.7848 13 36 13 293615;25106;25591;63868;299626;24360;308441;116636;65210;29184;246142;155423;25287 SIRT3_9828;RGN_9699;PARP1_9425;HSPD1_8849;GADD45B_8679;FABP1_33091;EXOSC5_32543;EIF4EBP1_8550;CYP2J4_32580;CD36_8243;BMF_8152;ANXA7_8051;ACADL_32776 54.928790769230766 42.2579 34.46893115683226 34.94438384615385 31.7336 19.41789044134023 70.59464384615384 69.1421 36.36100880540392 2.38018;77.4407;26.9741;42.2579;106.367;33.8478;41.9329;83.9001;17.8395;48.1296;94.8767;104.64;33.4878 0.56209;58.7732;21.799;23.9469;52.7132;26.4736;31.7336;42.4185;14.6501;37.5433;73.1342;43.9254;26.6039 8.82917;89.8047;35.2797;102.383;109.434;46.9257;62.1373;107.32;22.6149;69.1421;109.848;108.689;45.3228 36 79426;24522;246273;29573;79224;24794;24648;252922;83516;29441;25513;299282;288001;24516;54404;50693;306251;24471;24464;25675;25112;294515;25661;83928;24890;24330;116663;140942;25428;113936;25695;114851;79431;25377;25373;25303 ZFP36_10204;ZFP354A_10203;TRIB3_10079;SLC37A4_9871;SERPIND1_9812;SERPINA3C_32925;SERPINA1_9807;PZP_9633;PPARGC1A_33189;POR_9531;PIK3R1_32562;LOC299282_9119;KNG1L1_34113;JUN_8938;ITIH4_32725;ITIH3_32422;ITIH1_33132;HSPB1_8847;HP_8823;HMGCR_8810;GADD45A_8678;FOXO3_8662;FN1_8655;FETUB_33027;ESR1_33192;EGR1_8533;DUSP6_8506;DDIT4_8450;CYP7A1_8430;CPB2_8369;CEBPD_8283;CDKN1A_8271;BHLHE40_8141;AMBP_33085;AHSG_8003;ABCC2_32541 36.353140388888896 27.69285 31.137914198319212 24.45613264444445 20.9741 21.88955290008025 61.88560722222222 41.2117 52.64223684708369 0.348134;0.834827;108.064;39.7166;28.261;29.766;15.797;34.1871;42.4094;12.4414;18.7324;45.2017;24.3655;16.4324;57.1163;27.1247;98.1741;89.1011;64.9285;1.63089;102.919;13.1992;59.5777;32.5155;23.3972;0.750017;62.3934;87.5421;5.72128;25.8316;0.306936;6.24967;57.8085;17.2343;12.402;46.2316 0.118102;0.27095;83.8836;22.6911;22.307;23.347;13.013;26.3085;26.2988;8.48981;11.6701;30.7472;19.538;10.5224;39.6402;21.5108;42.9071;60.3265;41.6103;0.663137;89.5012;5.6804;31.0499;19.6094;18.3088;0.186019;39.0875;53.2453;0.985273;20.4374;0.0732342;2.44025;38.3491;14.1233;10.3013;31.1788 1.15962;2.99857;143.428;60.0334;38.3264;40.8256;19.9134;48.5666;81.7305;79.2355;41.5978;78.6415;32.1467;39.929;101.869;36.4819;104.278;106.138;136.455;7.6286;115.437;32.7581;105.243;49.9875;31.9156;4.70178;133.304;245.492;22.3625;34.8042;1.73689;19.0606;110.58;21.9073;15.4235;81.7848 0 Exp 2,16(0.33);Exp 3,4(0.09);Exp 4,3(0.07);Hill,6(0.13);Linear,8(0.17);Poly 2,10(0.21);Power,2(0.05) 1.952816549548598 100.54114854335785 1.5197933912277222 4.591650485992432 0.7755183695623551 1.7198865413665771 32.110942113496634 50.45180621303399 21.197382900836125 33.28007690324551 50.57569122562973 77.81664469273761 DOWN 0.2653061224489796 0.7346938775510204 0.0 GO:0007160 5 cell-matrix adhesion 28 28 2 2 2 2 2 2 160 26 2359 0.73822 0.5404 0.6976 7.14 25661;361969 fn1;fga FN1_8655;FGA_8632 44.079 44.079 28.5803 21.918471739151887 44.69382178145279 21.901218955439525 26.789450000000002 26.789450000000002 22.529 6.025186171812455 26.95845884969646 6.020443540342253 72.04705 72.04705 38.8511 46.94616270585912 73.36390838915636 46.90920976493652 0.5 44.079 59.5777;28.5803 31.0499;22.529 105.243;38.8511 0 2 0 2 25661;361969 FN1_8655;FGA_8632 44.079 44.079 21.918471739151887 26.789450000000002 26.789450000000002 6.025186171812455 72.04705 72.04705 46.94616270585912 59.5777;28.5803 31.0499;22.529 105.243;38.8511 0 Linear,1(0.5);Power,1(0.5) 1.6563190798989507 3.3211294412612915 1.541895866394043 1.7792335748672485 0.1678231030926796 1.6605647206306458 13.701548000000006 74.456452 18.438968000000003 35.139932 6.98298800000002 137.111112 DOWN 0.0 1.0 0.0 GO:2000278 7 regulation of DNA biosynthetic process 42 46 4 4 4 3 3 3 159 43 2342 0.66479 0.56884 1.0 6.52 25106;303612;114851 rgn;polg2;cdkn1a RGN_9699;POLG2_9521;CDKN1A_8271 49.155390000000004 63.7758 6.24967 37.78039146887312 39.12410884727976 40.432736242307826 34.05625 40.9553 2.44025 28.793193329370396 26.94074811930406 30.782424941732415 80.47743333333334 89.8047 19.0606 57.32516147245757 63.896285617232806 57.57419840554657 1.5 70.60825 77.4407;63.7758;6.24967 58.7732;40.9553;2.44025 89.8047;132.567;19.0606 1 2 1 25106 RGN_9699 77.4407 77.4407 58.7732 58.7732 89.8047 89.8047 77.4407 58.7732 89.8047 2 303612;114851 POLG2_9521;CDKN1A_8271 35.012735 35.012735 40.677116618418886 21.697775 21.697775 27.234253032738938 75.8138 75.8138 80.26114514807276 63.7758;6.24967 40.9553;2.44025 132.567;19.0606 0 Exp 2,1(0.34);Exp 4,1(0.34);Poly 2,1(0.34) 1.595148417755052 4.792445540428162 1.522104263305664 1.7198865413665771 0.10694914333115253 1.5504547357559204 6.402852398099064 91.90792760190092 1.4736844776997629 66.63881552230023 15.607906414707543 145.34696025195913 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0051254 7 positive regulation of RNA metabolic process 320 346 24 24 19 20 17 17 145 329 2056 0.14166 0.90762 0.28563 4.91 79426;24825;293615;83516;25513;81819;25591;25493;58954;24516;494344;290556;294515;314322;24890;24330;25695 zfp36;tf;sirt3;ppargc1a;pik3r1;pax8;parp1;nfkbia;klf6;jun;ier2;gnl3;foxo3;fos;esr1;egr1;cebpd ZFP36_10204;TF_10003;SIRT3_9828;PPARGC1A_33189;PIK3R1_32562;PAX8_9432;PARP1_9425;NFKBIA_9307;KLF6_8969;JUN_8938;IER2_32643;GNL3_8735;FOXO3_8662;FOS_8657;ESR1_33192;EGR1_8533;CEBPD_8283 23.75069517647066 18.7324 1.28141E-12 25.085842707304412 26.572925692452923 22.77780279406633 15.776120423529486 11.6701 1.28141E-12 16.945454882074475 18.32528735337031 16.367050290888862 47.03397352941184 35.2797 1.28142E-12 57.80560816625617 46.05047211503998 41.521334863093564 0.348134;45.1539;2.38018;42.4094;18.7324;56.8931;26.9741;0.520151;18.9476;16.4324;49.6814;87.6357;13.1992;1.28141E-12;23.3972;0.750017;0.306936 0.118102;28.132;0.56209;26.2988;11.6701;45.1162;21.799;0.160202;11.6941;10.5224;33.4626;54.41;5.6804;1.28141E-12;18.3088;0.186019;0.0732342 1.15962;61.5341;8.82917;81.7305;41.5978;81.5688;35.2797;2.88499;45.5481;39.929;89.4404;238.963;32.7581;1.28142E-12;31.9156;4.70178;1.73689 5 12 5 24825;293615;81819;25591;290556 TF_10003;SIRT3_9828;PAX8_9432;PARP1_9425;GNL3_8735 43.807396 45.1539 31.99040103471791 30.003858 28.132 20.98620915141226 85.23495399999999 61.5341 90.19541912331013 45.1539;2.38018;56.8931;26.9741;87.6357 28.132;0.56209;45.1162;21.799;54.41 61.5341;8.82917;81.5688;35.2797;238.963 12 79426;83516;25513;25493;58954;24516;494344;294515;314322;24890;24330;25695 ZFP36_10204;PPARGC1A_33189;PIK3R1_32562;NFKBIA_9307;KLF6_8969;JUN_8938;IER2_32643;FOXO3_8662;FOS_8657;ESR1_33192;EGR1_8533;CEBPD_8283 15.393736500000108 14.8158 16.857228545145404 9.84789643333344 8.1014 11.276776221790277 31.11689833333344 32.33685 31.022198659070053 0.348134;42.4094;18.7324;0.520151;18.9476;16.4324;49.6814;13.1992;1.28141E-12;23.3972;0.750017;0.306936 0.118102;26.2988;11.6701;0.160202;11.6941;10.5224;33.4626;5.6804;1.28141E-12;18.3088;0.186019;0.0732342 1.15962;81.7305;41.5978;2.88499;45.5481;39.929;89.4404;32.7581;1.28142E-12;31.9156;4.70178;1.73689 0 Exp 2,6(0.36);Exp 4,2(0.12);Hill,5(0.3);Poly 2,4(0.24) 1.8926609495274846 33.208152413368225 1.5209722518920898 4.21828556060791 0.621536669869514 1.8086696863174438 11.825642516935412 35.67574783600591 7.720762500485616 23.831478346573356 19.554931687283585 74.51301537154009 DOWN 0.29411764705882354 0.7058823529411765 0.0 GO:0034036 8 purine ribonucleoside bisphosphate biosynthetic process 2 2 1 1 1 1 1 1 161 1 2384 0.99598 0.12319 0.12319 50.0 294103 papss2 PAPSS2_33237 34.4443 34.4443 34.4443 34.4443 25.719 25.719 25.719 25.719 51.1014 51.1014 51.1014 51.1014 0.0 34.4443 0.0 34.4443 34.4443 25.719 51.1014 0 1 0 1 294103 PAPSS2_33237 34.4443 34.4443 25.719 25.719 51.1014 51.1014 34.4443 25.719 51.1014 0 Exp 2,1(1) 1.8057876825332642 1.8057876825332642 1.8057876825332642 1.8057876825332642 0.0 1.8057876825332642 34.4443 34.4443 25.719 25.719 51.1014 51.1014 DOWN 0.0 1.0 0.0 GO:0050428 8 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process 2 2 1 1 1 1 1 1 161 1 2384 0.99598 0.12319 0.12319 50.0 294103 papss2 PAPSS2_33237 34.4443 34.4443 34.4443 34.4443 25.719 25.719 25.719 25.719 51.1014 51.1014 51.1014 51.1014 0.0 34.4443 0.0 34.4443 34.4443 25.719 51.1014 0 1 0 1 294103 PAPSS2_33237 34.4443 34.4443 25.719 25.719 51.1014 51.1014 34.4443 25.719 51.1014 0 Exp 2,1(1) 1.8057876825332642 1.8057876825332642 1.8057876825332642 1.8057876825332642 0.0 1.8057876825332642 34.4443 34.4443 25.719 25.719 51.1014 51.1014 DOWN 0.0 1.0 0.0 GO:0097327 5 response to antineoplastic agent 75 80 18 18 14 14 10 10 152 70 2315 0.98895 0.028073 0.032852 12.5 25513;294515;361969;116636;24330;140942;497840;25698;312382;25303 pik3r1;foxo3;fga;eif4ebp1;egr1;ddit4;cps1;ass1;abcg2;abcc2 PIK3R1_32562;FOXO3_8662;FGA_8632;EIF4EBP1_8550;EGR1_8533;DDIT4_8450;CPS1_32421;ASS1_33159;ABCG2_32656;ABCC2_32541 34.2938557 27.692 0.750017 30.16726812156893 30.886450159435007 28.26985905219545 21.5107899 21.75575 0.186019 17.32885027394535 19.73478761610257 15.664130387331783 64.618878 40.224450000000004 4.70178 70.40134189259271 50.04624799264057 51.87918229351211 3.0 18.7324 7.0 46.2316 18.7324;13.1992;28.5803;83.9001;0.750017;87.5421;31.9826;26.8037;5.21654;46.2316 11.6701;5.6804;22.529;42.4185;0.186019;53.2453;24.4836;20.9825;2.73368;31.1788 41.5978;32.7581;38.8511;107.32;4.70178;245.492;45.5891;36.7081;11.386;81.7848 2 8 2 116636;312382 EIF4EBP1_8550;ABCG2_32656 44.558319999999995 44.558319999999995 55.637678843898584 22.57609 22.57609 28.061405332167524 59.352999999999994 59.352999999999994 67.83558194635026 83.9001;5.21654 42.4185;2.73368 107.32;11.386 8 25513;294515;361969;24330;140942;497840;25698;25303 PIK3R1_32562;FOXO3_8662;FGA_8632;EGR1_8533;DDIT4_8450;CPS1_32421;ASS1_33159;ABCC2_32541 31.727739625 27.692 26.272275494781645 21.244464875 21.75575 16.528425023825257 65.9353475 40.224450000000004 75.53253850089315 18.7324;13.1992;28.5803;0.750017;87.5421;31.9826;26.8037;46.2316 11.6701;5.6804;22.529;0.186019;53.2453;24.4836;20.9825;31.1788 41.5978;32.7581;38.8511;4.70178;245.492;45.5891;36.7081;81.7848 0 Exp 2,3(0.3);Exp 3,1(0.1);Exp 4,2(0.2);Hill,1(0.1);Linear,2(0.2);Poly 2,1(0.1) 1.8899009537833262 19.836479663848877 1.5074360370635986 4.21828556060791 0.7999383155826986 1.7500277757644653 15.59598920236716 52.99172219763284 10.77025722485079 32.25132257514922 20.98367422028685 108.25408177971315 DOWN 0.2 0.8 0.0 GO:1900077 6 negative regulation of cellular response to insulin stimulus 19 19 2 2 2 2 2 2 160 17 2368 0.88421 0.34304 0.34304 10.53 24539;25373 lpl;ahsg LPL_32544;AHSG_8003 43.30305 43.30305 12.402 43.70068400156913 56.24497988648173 39.68327965065114 30.08475 30.08475 10.3013 27.978023300530015 38.37042387880726 25.40600331719065 85.42425 85.42425 15.4235 98.99601002628846 114.74185566392198 89.89530575839065 0.0 12.402 0.5 43.30305 74.2041;12.402 49.8682;10.3013 155.425;15.4235 1 1 1 24539 LPL_32544 74.2041 74.2041 49.8682 49.8682 155.425 155.425 74.2041 49.8682 155.425 1 25373 AHSG_8003 12.402 12.402 10.3013 10.3013 15.4235 15.4235 12.402 10.3013 15.4235 0 Exp 2,2(1) 2.313212807461259 4.990819215774536 1.559399127960205 3.431420087814331 1.3237187152362022 2.495409607887268 -17.263007999999992 103.86910799999998 -8.690812000000001 68.860312 -51.77722 222.62572 CONFLICT 0.5 0.5 0.0 GO:0022408 7 negative regulation of cell-cell adhesion 60 62 4 4 3 4 3 3 159 59 2326 0.43621 0.76661 0.79558 4.84 25513;246186;25698 pik3r1;fgl1;ass1 PIK3R1_32562;FGL1_8640;ASS1_33159 20.337266666666668 18.7324 15.4757 5.832031701159833 19.42746239116585 6.075888075090992 14.2888 11.6701 10.2138 5.842466704226912 13.687376173285198 5.873513673076716 36.23883333333333 36.7081 30.4106 5.608343727281121 34.22635092376301 5.32643540856894 18.7324;15.4757;26.8037 11.6701;10.2138;20.9825 41.5978;30.4106;36.7081 0 3 0 3 25513;246186;25698 PIK3R1_32562;FGL1_8640;ASS1_33159 20.337266666666668 18.7324 5.832031701159833 14.2888 11.6701 5.842466704226912 36.23883333333333 36.7081 5.608343727281121 18.7324;15.4757;26.8037 11.6701;10.2138;20.9825 41.5978;30.4106;36.7081 0 Exp 2,1(0.34);Poly 2,2(0.67) 1.6820173954131354 5.066331624984741 1.511321783065796 1.8814297914505005 0.1855214264522698 1.6735800504684448 13.737701524396023 26.936831808937313 7.6774265401430135 20.900173459856987 29.892394962452087 42.58527170421458 DOWN 0.0 1.0 0.0 GO:0043086 5 negative regulation of catalytic activity 212 228 30 30 26 29 25 25 137 203 2182 0.99816 0.0039136 0.006189 10.96 79426;246273;79224;24794;24648;25106;252922;29441;24314;299282;288001;54404;50693;306251;24471;24464;25675;299626;25112;83928;24360;116663;114851;25377;25373 zfp36;trib3;serpind1;serpina3c;serpina1;rgn;pzp;por;nqo1;loc299282;kng1;itih4;itih3;itih1;hspb1;hp;hmgcr;gadd45b;gadd45a;fetub;fabp1;dusp6;cdkn1a;ambp;ahsg ZFP36_10204;TRIB3_10079;SERPIND1_9812;SERPINA3C_32925;SERPINA1_9807;RGN_9699;PZP_9633;POR_9531;NQO1_33055;LOC299282_9119;KNG1L1_34113;ITIH4_32725;ITIH3_32422;ITIH1_33132;HSPB1_8847;HP_8823;HMGCR_8810;GADD45B_8679;GADD45A_8678;FETUB_33027;FABP1_33091;DUSP6_8506;CDKN1A_8271;AMBP_33085;AHSG_8003 47.006131759999995 33.8478 0.348134 35.49237987586264 52.28763425761176 34.49867356659586 32.325295960000005 26.3085 0.118102 24.42293719736288 35.80687544952649 25.258938187196872 70.9398048 49.9875 1.15962 51.00960122578306 78.12840866756049 43.331552923943626 10.5 31.14075 21.5 100.54655 0.348134;108.064;28.261;29.766;15.797;77.4407;34.1871;12.4414;87.2765;45.2017;24.3655;57.1163;27.1247;98.1741;89.1011;64.9285;1.63089;106.367;102.919;32.5155;33.8478;62.3934;6.24967;17.2343;12.402 0.118102;83.8836;22.307;23.347;13.013;58.7732;26.3085;8.48981;60.6992;30.7472;19.538;39.6402;21.5108;42.9071;60.3265;41.6103;0.663137;52.7132;89.5012;19.6094;26.4736;39.0875;2.44025;14.1233;10.3013 1.15962;143.428;38.3264;40.8256;19.9134;89.8047;48.5666;79.2355;197.117;78.6415;32.1467;101.869;36.4819;104.278;106.138;136.455;7.6286;109.434;115.437;49.9875;46.9257;133.304;19.0606;21.9073;15.4235 4 21 4 25106;24314;299626;24360 RGN_9699;NQO1_33055;GADD45B_8679;FABP1_33091 76.233 82.3586 30.70277168042 49.6648 55.7432 15.83082893091832 110.82034999999999 99.61935 63.17493598754178 77.4407;87.2765;106.367;33.8478 58.7732;60.6992;52.7132;26.4736 89.8047;197.117;109.434;46.9257 21 79426;246273;79224;24794;24648;252922;29441;299282;288001;54404;50693;306251;24471;24464;25675;25112;83928;116663;114851;25377;25373 ZFP36_10204;TRIB3_10079;SERPIND1_9812;SERPINA3C_32925;SERPINA1_9807;PZP_9633;POR_9531;LOC299282_9119;KNG1L1_34113;ITIH4_32725;ITIH3_32422;ITIH1_33132;HSPB1_8847;HP_8823;HMGCR_8810;GADD45A_8678;FETUB_33027;DUSP6_8506;CDKN1A_8271;AMBP_33085;AHSG_8003 41.439109238095234 29.766 34.15945717664463 29.022533285714292 22.307 24.629214938811486 63.34351047619049 48.5666 46.31451145359415 0.348134;108.064;28.261;29.766;15.797;34.1871;12.4414;45.2017;24.3655;57.1163;27.1247;98.1741;89.1011;64.9285;1.63089;102.919;32.5155;62.3934;6.24967;17.2343;12.402 0.118102;83.8836;22.307;23.347;13.013;26.3085;8.48981;30.7472;19.538;39.6402;21.5108;42.9071;60.3265;41.6103;0.663137;89.5012;19.6094;39.0875;2.44025;14.1233;10.3013 1.15962;143.428;38.3264;40.8256;19.9134;48.5666;79.2355;78.6415;32.1467;101.869;36.4819;104.278;106.138;136.455;7.6286;115.437;49.9875;133.304;19.0606;21.9073;15.4235 0 Exp 2,8(0.32);Exp 3,1(0.04);Exp 4,2(0.08);Hill,1(0.04);Linear,6(0.24);Poly 2,6(0.24);Power,1(0.04) 1.8140008970597747 46.35386872291565 1.5197933912277222 3.431420087814331 0.4502762251654502 1.679053544998169 33.093118848661845 60.91914467133816 22.751504578633753 41.899087341366254 50.94404111949303 90.93556848050696 DOWN 0.16 0.84 0.0 GO:0098542 4 defense response to other organism 155 169 10 10 8 9 7 7 155 162 2223 0.14268 0.92454 0.2561 4.14 246074;24464;361969;308441;140942;29184;313421 scd;hp;fga;exosc5;ddit4;cd36;c8b SCD1_9787;HP_8823;FGA_8632;EXOSC5_32543;DDIT4_8450;CD36_8243;C8B_8181 56.84788571428572 48.1296 21.3618 30.89593489783774 52.01929261675072 27.376600484907684 38.23192857142857 37.5433 17.2088 16.42866597685423 35.98825045220347 14.723449254605764 143.2418 69.1421 27.9161 144.25881340692268 118.04260235419866 126.80003853230544 105.46;64.9285;28.5803;41.9329;87.5421;48.1296;21.3618 63.7532;41.6103;22.529;31.7336;53.2453;37.5433;17.2088 422.699;136.455;38.8511;62.1373;245.492;69.1421;27.9161 3 4 3 246074;308441;29184 SCD1_9787;EXOSC5_32543;CD36_8243 65.17416666666666 48.1296 35.02586256244568 44.34336666666667 37.5433 17.05855726734629 184.65946666666665 69.1421 206.17803320898025 105.46;41.9329;48.1296 63.7532;31.7336;37.5433 422.699;62.1373;69.1421 4 24464;361969;140942;313421 HP_8823;FGA_8632;DDIT4_8450;C8B_8181 50.603175 46.754400000000004 31.143560873624697 33.64835 32.06965 16.746460777629007 112.17855 87.65305000000001 101.38852232708592 64.9285;28.5803;87.5421;21.3618 41.6103;22.529;53.2453;17.2088 136.455;38.8511;245.492;27.9161 0 Exp 2,5(0.72);Linear,2(0.29) 1.7974423667096577 12.860090017318726 1.5122476816177368 2.6703107357025146 0.4423679812833654 1.6336230039596558 33.95985684077999 79.73591458779144 26.06140249818337 50.40245464467378 36.37337548288342 250.1102245171166 CONFLICT 0.42857142857142855 0.5714285714285714 0.0 GO:0045930 7 negative regulation of mitotic cell cycle 62 67 5 5 4 4 3 3 159 64 2321 0.37356 0.81097 0.79782 4.48 257644;25112;114851 zwint;gadd45a;cdkn1a ZWINT_10214;GADD45A_8678;CDKN1A_8271 53.72299 52.0003 6.24967 48.35768383917181 53.997006026538706 55.39002205513844 43.61431666666667 38.9015 2.44025 43.721393326675134 44.85038375361112 49.95340488644842 71.7863 80.8613 19.0606 48.82488441348325 68.68218192723889 55.50084340913016 52.0003;102.919;6.24967 38.9015;89.5012;2.44025 80.8613;115.437;19.0606 1 2 1 257644 ZWINT_10214 52.0003 52.0003 38.9015 38.9015 80.8613 80.8613 52.0003 38.9015 80.8613 2 25112;114851 GADD45A_8678;CDKN1A_8271 54.584334999999996 54.584334999999996 68.35553877576015 45.970725 45.970725 61.56138812154295 67.2488 67.2488 68.14840598634717 102.919;6.24967 89.5012;2.44025 115.437;19.0606 0 Exp 2,1(0.34);Exp 4,1(0.34);Poly 2,1(0.34) 1.558064902291925 4.676859974861145 1.5207922458648682 1.6339634656906128 0.06496399970343689 1.522104263305664 -0.9988806925880311 108.44486069258802 -5.861097418076078 93.0897307514094 16.53574208781724 127.03685791218275 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0051791 7 medium-chain fatty acid metabolic process 7 8 6 6 3 5 2 2 160 6 2379 0.98885 0.087405 0.087405 25.0 83842;24158 crot;acadm CROT_8384;ACADM_7957 9.5683 9.5683 7.4229 3.0340537767152362 10.0101738292011 2.9690027548209343 7.059290000000001 7.059290000000001 5.75707 1.8416171851934884 7.3274996289094165 1.8021323610435844 14.6401 14.6401 10.316 6.115200865057505 15.530706238859183 5.984089126559719 0.0 7.4229 0.0 7.4229 7.4229;11.7137 5.75707;8.36151 10.316;18.9642 2 0 2 83842;24158 CROT_8384;ACADM_7957 9.5683 9.5683 3.0340537767152362 7.059290000000001 7.059290000000001 1.8416171851934884 14.6401 14.6401 6.115200865057505 7.4229;11.7137 5.75707;8.36151 10.316;18.9642 0 0 Poly 2,2(1) 3.177527052346699 7.656625032424927 1.693061113357544 5.963563919067383 3.019701492993604 3.8283125162124634 5.363316000000002 13.773284 4.5069388 9.611641200000001 6.1648640000000015 23.115336 UP 1.0 0.0 0.0 GO:0021960 12 anterior commissure morphogenesis 1 1 1 1 1 1 1 1 161 0 2385 1.0 0.063604 0.063604 100.0 308843 tsku TSKU_10094 1.38416 1.38416 1.38416 1.3841600000000003 0.540568 0.540568 0.540568 0.540568 4.10872 4.10872 4.10872 4.10872 0.0 1.38416 0.0 1.38416 1.38416 0.540568 4.10872 0 1 0 1 308843 TSKU_10094 1.38416 1.38416 0.540568 0.540568 4.10872 4.10872 1.38416 0.540568 4.10872 0 Hill,1(1) 2.974404573440552 2.9744045734405518 2.9744045734405518 2.9744045734405518 0.0 2.9744045734405518 1.38416 1.38416 0.540568 0.540568 4.10872 4.10872 DOWN 0.0 1.0 0.0 GO:0030330 7 DNA damage response, signal transduction by p53 class mediator 13 14 3 3 3 2 2 2 160 12 2373 0.94527 0.22236 0.22236 14.29 294515;114851 foxo3;cdkn1a FOXO3_8662;CDKN1A_8271 9.724435 9.724435 6.24967 4.9140597890593485 7.388651257785629 3.638160555784206 4.060325 4.060325 2.44025 2.2911320370615917 2.971288807288278 1.6962565705629273 25.90935 25.90935 19.0606 9.685595135302725 21.3055281862973 7.170802084868187 0.0 6.24967 0.5 9.724435 13.1992;6.24967 5.6804;2.44025 32.7581;19.0606 0 2 0 2 294515;114851 FOXO3_8662;CDKN1A_8271 9.724435 9.724435 4.9140597890593485 4.060325 4.060325 2.2911320370615917 25.90935 25.90935 9.685595135302725 13.1992;6.24967 5.6804;2.44025 32.7581;19.0606 0 Exp 4,2(1) 1.7396731927449798 3.5104455947875977 1.522104263305664 1.9883413314819336 0.32967939254797485 1.7552227973937988 2.913895600000002 16.534974399999996 0.8849780000000003 7.235671999999999 12.485800000000001 39.332899999999995 DOWN 0.0 1.0 0.0 GO:0031328 7 positive regulation of cellular biosynthetic process 404 436 34 34 27 28 23 23 139 413 1972 0.1817 0.87171 0.33381 5.28 24825;293615;25106;83516;29441;303612;25513;81819;25591;25493;58954;24516;494344;24471;290556;294515;314322;24890;24330;25146;25695;29184;25698 tf;sirt3;rgn;ppargc1a;por;polg2;pik3r1;pax8;parp1;nfkbia;klf6;jun;ier2;hspb1;gnl3;foxo3;fos;esr1;egr1;cyp17a1;cebpd;cd36;ass1 TF_10003;SIRT3_9828;RGN_9699;PPARGC1A_33189;POR_9531;POLG2_9521;PIK3R1_32562;PAX8_9432;PARP1_9425;NFKBIA_9307;KLF6_8969;JUN_8938;IER2_32643;HSPB1_8847;GNL3_8735;FOXO3_8662;FOS_8657;ESR1_33192;EGR1_8533;CYP17A1_32365;CEBPD_8283;CD36_8243;ASS1_33159 33.512964521739185 26.8037 1.28141E-12 28.194924712115185 36.25822315506418 26.9067899016729 23.078780660869622 20.9825 1.28141E-12 19.701989470924495 25.58875207473613 19.285771006270537 60.593662173913096 45.5481 1.28142E-12 53.34235425178504 59.95150344574969 40.41607480105327 20.5 82.5382 45.1539;2.38018;77.4407;42.4094;12.4414;63.7758;18.7324;56.8931;26.9741;0.520151;18.9476;16.4324;49.6814;89.1011;87.6357;13.1992;1.28141E-12;23.3972;0.750017;49.6922;0.306936;48.1296;26.8037 28.132;0.56209;58.7732;26.2988;8.48981;40.9553;11.6701;45.1162;21.799;0.160202;11.6941;10.5224;33.4626;60.3265;54.41;5.6804;1.28141E-12;18.3088;0.186019;35.6654;0.0732342;37.5433;20.9825 61.5341;8.82917;89.8047;81.7305;79.2355;132.567;41.5978;81.5688;35.2797;2.88499;45.5481;39.929;89.4404;106.138;238.963;32.7581;1.28142E-12;31.9156;4.70178;81.6409;1.73689;69.1421;36.7081 8 15 8 24825;293615;25106;81819;25591;290556;25146;29184 TF_10003;SIRT3_9828;RGN_9699;PAX8_9432;PARP1_9425;GNL3_8735;CYP17A1_32365;CD36_8243 49.287434999999995 48.9109 26.826979802879162 35.25014875 36.60435 18.739060228460485 83.34530874999999 75.35544999999999 68.45756579545808 45.1539;2.38018;77.4407;56.8931;26.9741;87.6357;49.6922;48.1296 28.132;0.56209;58.7732;45.1162;21.799;54.41;35.6654;37.5433 61.5341;8.82917;89.8047;81.5688;35.2797;238.963;81.6409;69.1421 15 83516;29441;303612;25513;25493;58954;24516;494344;24471;294515;314322;24890;24330;25695;25698 PPARGC1A_33189;POR_9531;POLG2_9521;PIK3R1_32562;NFKBIA_9307;KLF6_8969;JUN_8938;IER2_32643;HSPB1_8847;FOXO3_8662;FOS_8657;ESR1_33192;EGR1_8533;CEBPD_8283;ASS1_33159 25.099913600000082 18.7324 25.910301996832885 16.587384346666752 11.6701 17.452848543274364 48.459450666666754 39.929 40.9216976547929 42.4094;12.4414;63.7758;18.7324;0.520151;18.9476;16.4324;49.6814;89.1011;13.1992;1.28141E-12;23.3972;0.750017;0.306936;26.8037 26.2988;8.48981;40.9553;11.6701;0.160202;11.6941;10.5224;33.4626;60.3265;5.6804;1.28141E-12;18.3088;0.186019;0.0732342;20.9825 81.7305;79.2355;132.567;41.5978;2.88499;45.5481;39.929;89.4404;106.138;32.7581;1.28142E-12;31.9156;4.70178;1.73689;36.7081 0 Exp 2,9(0.4);Exp 4,2(0.09);Hill,4(0.18);Linear,1(0.05);Poly 2,7(0.31) 1.8898071973279453 44.68070864677429 1.5209722518920898 4.21828556060791 0.563366187988184 1.8086696863174438 21.990030038508326 45.03589900497006 15.026809031904206 31.130752289835037 38.793268681090794 82.3940556667354 DOWN 0.34782608695652173 0.6521739130434783 0.0 GO:0051054 7 positive regulation of DNA metabolic process 56 60 5 5 5 4 4 4 158 56 2329 0.66655 0.53721 0.79055 6.67 83516;303612;25591;290556 ppargc1a;polg2;parp1;gnl3 PPARGC1A_33189;POLG2_9521;PARP1_9425;GNL3_8735 55.198750000000004 53.0926 26.9741 26.36866734750417 43.37511263628434 20.934565124093737 35.865775 33.62705 21.799 14.823323009450338 29.339277038813783 11.315975867467193 122.13505 107.14875 35.2797 87.43373675023845 83.12962929023115 63.79714025207035 2.0 63.7758 42.4094;63.7758;26.9741;87.6357 26.2988;40.9553;21.799;54.41 81.7305;132.567;35.2797;238.963 2 2 2 25591;290556 PARP1_9425;GNL3_8735 57.3049 57.3049 42.89422871762586 38.1045 38.1045 23.059459241274496 137.12135 137.12135 144.0258426444539 26.9741;87.6357 21.799;54.41 35.2797;238.963 2 83516;303612 PPARGC1A_33189;POLG2_9521 53.0926 53.0926 15.108326329544246 33.62705 33.62705 10.363710538460639 107.14875 107.14875 35.946833881789956 42.4094;63.7758 26.2988;40.9553 81.7305;132.567 0 Exp 2,4(1) 1.671182482871784 6.699275493621826 1.5504547357559204 1.8086696863174438 0.12748414425219748 1.670075535774231 29.357455999445897 81.0400440005541 21.338918450738667 50.39263154926133 36.44998798476631 207.8201120152337 CONFLICT 0.5 0.5 0.0 GO:0035994 5 response to muscle stretch 14 14 4 4 4 4 4 4 158 10 2375 0.99878 0.0095446 0.0095446 28.57 25493;24516;24471;314322 nfkbia;jun;hspb1;fos NFKBIA_9307;JUN_8938;HSPB1_8847;FOS_8657 26.51341275000032 8.4762755 1.28141E-12 42.41641241086318 47.59706973261979 47.21469065847465 17.75227550000032 5.341301 1.28141E-12 28.806596622875336 32.05718834880631 32.124373776305916 37.23799750000032 21.406995000000002 1.28142E-12 49.40057159271196 62.007145739240904 52.23724110058655 0.0 1.28141E-12 0.5 0.2600755000006407 0.520151;16.4324;89.1011;1.28141E-12 0.160202;10.5224;60.3265;1.28141E-12 2.88499;39.929;106.138;1.28142E-12 0 4 0 4 25493;24516;24471;314322 NFKBIA_9307;JUN_8938;HSPB1_8847;FOS_8657 26.51341275000032 8.4762755 42.41641241086318 17.75227550000032 5.341301 28.806596622875336 37.23799750000032 21.406995000000002 49.40057159271196 0.520151;16.4324;89.1011;1.28141E-12 0.160202;10.5224;60.3265;1.28141E-12 2.88499;39.929;106.138;1.28142E-12 0 Exp 4,1(0.25);Hill,1(0.25);Poly 2,2(0.5) 1.8538981786217856 7.427097797393799 1.6973176002502441 1.9785058498382568 0.11809774638643263 1.875637173652649 -15.054671412645593 68.08149691264624 -10.478189190417503 45.98274019041814 -11.174562660857397 85.65055766085806 DOWN 0.0 1.0 0.0 GO:0048661 7 positive regulation of smooth muscle cell proliferation 52 55 6 6 6 4 4 4 158 51 2334 0.73023 0.46756 0.77666 7.27 83516;24516;25675;24330 ppargc1a;jun;hmgcr;egr1 PPARGC1A_33189;JUN_8938;HMGCR_8810;EGR1_8533 15.30567675 9.031645000000001 0.750017 19.448636136504334 18.096088755081055 21.026746583462568 9.417589 5.5927685 0.186019 12.22099568580572 11.162728772985725 13.176007310291906 33.49747 23.7788 4.70178 35.89883915845934 38.204550971449315 38.75492279851065 1.5 9.031645000000001 42.4094;16.4324;1.63089;0.750017 26.2988;10.5224;0.663137;0.186019 81.7305;39.929;7.6286;4.70178 0 4 0 4 83516;24516;25675;24330 PPARGC1A_33189;JUN_8938;HMGCR_8810;EGR1_8533 15.30567675 9.031645000000001 19.448636136504334 9.417589 5.5927685 12.22099568580572 33.49747 23.7788 35.89883915845934 42.4094;16.4324;1.63089;0.750017 26.2988;10.5224;0.663137;0.186019 81.7305;39.929;7.6286;4.70178 0 Exp 2,1(0.25);Exp 4,1(0.25);Hill,1(0.25);Poly 2,1(0.25) 2.2982076707282673 9.856184601783752 1.7576230764389038 4.21828556060791 1.173071920403847 1.9401379823684692 -3.753986663774244 34.36534016377425 -2.5589867720896056 21.394164772089603 -1.683392375290147 68.67833237529015 DOWN 0.0 1.0 0.0 GO:0006839 5 mitochondrial transport 32 33 4 4 4 4 4 4 158 29 2356 0.94539 0.1542 0.1542 12.12 171139;361074;100359982;63868 timm9;slc25a30;mpc2;hspd1 TIMM9_10020;SLC25A30_9856;MPC2_33219;HSPD1_8849 171139(0.04986) 45.159075 44.552099999999996 38.5191 6.245984056108901 47.84147377442901 5.83271784293615 31.706675 32.6997 23.9469 6.201167253227417 32.82295390157759 6.819552938531877 79.30947499999999 79.69319999999999 55.4685 21.010817051442064 87.41313731575228 16.018949184430817 0.5 40.3885 2.5 49.929649999999995 38.5191;53.013;46.8463;42.2579 29.55;37.4804;35.8494;23.9469 55.4685;90.2594;69.127;102.383 4 0 4 171139;361074;100359982;63868 TIMM9_10020;SLC25A30_9856;MPC2_33219;HSPD1_8849 45.159075 44.552099999999996 6.245984056108901 31.706675 32.6997 6.201167253227417 79.30947499999999 79.69319999999999 21.010817051442064 38.5191;53.013;46.8463;42.2579 29.55;37.4804;35.8494;23.9469 55.4685;90.2594;69.127;102.383 0 0 Exp 2,2(0.5);Exp 3,1(0.25);Linear,1(0.25) 2.249366640193036 9.443795204162598 1.620712399482727 3.648852586746216 0.8964543938147927 2.0871151089668274 39.03801062501327 51.28013937498673 25.629531091837137 37.783818908162864 58.718874289586836 99.90007571041318 UP 1.0 0.0 0.0 GO:0033365 6 protein localization to organelle 115 123 9 9 8 9 8 8 154 115 2270 0.61896 0.52876 0.8508 6.5 171139;297784;25513;25493;63868;85255;24890;114851 timm9;rrs1;pik3r1;nfkbia;hspd1;hacl1;esr1;cdkn1a TIMM9_10020;RRS1_9755;PIK3R1_32562;NFKBIA_9307;HSPD1_8849;HACL1_8775;ESR1_33192;CDKN1A_8271 171139(0.04986) 25.961740125 21.064799999999998 0.520151 19.902250916120096 25.35657198744984 20.570132932665704 17.5475315 14.989450000000001 0.160202 14.364775408991484 16.073778976492328 14.581575104943507 49.48823625 39.6256 2.88499 36.87345732866777 53.25941949926738 39.200917073574686 5.5 40.3885 38.5191;60.39;18.7324;0.520151;42.2579;17.6275;23.3972;6.24967 29.55;43.109;11.6701;0.160202;23.9469;11.195;18.3088;2.44025 55.4685;104.942;41.5978;2.88499;102.383;37.6534;31.9156;19.0606 4 4 4 171139;297784;63868;85255 TIMM9_10020;RRS1_9755;HSPD1_8849;HACL1_8775 39.69862500000001 40.3885 17.542412661010047 26.950225000000003 26.74845 13.230166481788245 75.11172499999999 78.92575 33.77647182535746 38.5191;60.39;42.2579;17.6275 29.55;43.109;23.9469;11.195 55.4685;104.942;102.383;37.6534 4 25513;25493;24890;114851 PIK3R1_32562;NFKBIA_9307;ESR1_33192;CDKN1A_8271 12.224855250000001 12.491035 10.643814576831163 8.144838 7.055175 8.406948158286058 23.8647475 25.488100000000003 16.758156570310028 18.7324;0.520151;23.3972;6.24967 11.6701;0.160202;18.3088;2.44025 41.5978;2.88499;31.9156;19.0606 0 Exp 2,3(0.38);Exp 3,1(0.13);Exp 4,2(0.25);Poly 2,2(0.25) 1.8927700018328246 15.3598393201828 1.522104263305664 2.436986207962036 0.35093535793028857 1.786325752735138 12.170183873008602 39.75329637699139 7.593250000118751 27.501812999881253 23.93623396156408 75.0402385384359 CONFLICT 0.5 0.5 0.0 GO:0006863 7 purine nucleobase transport 1 1 1 1 1 1 1 1 161 0 2385 1.0 0.063604 0.063604 100.0 65054 aqp9 AQP9_32709 27.7316 27.7316 27.7316 27.731600000000004 21.9372 21.9372 21.9372 21.9372 37.4625 37.4625 37.4625 37.4625 0.0 27.7316 0.0 27.7316 27.7316 21.9372 37.4625 0 1 0 1 65054 AQP9_32709 27.7316 27.7316 21.9372 21.9372 37.4625 37.4625 27.7316 21.9372 37.4625 0 Linear,1(1) 1.8171201944351196 1.8171201944351196 1.8171201944351196 1.8171201944351196 0.0 1.8171201944351196 27.7316 27.7316 21.9372 21.9372 37.4625 37.4625 DOWN 0.0 1.0 0.0 GO:0015855 7 pyrimidine nucleobase transport 1 1 1 1 1 1 1 1 161 0 2385 1.0 0.063604 0.063604 100.0 65054 aqp9 AQP9_32709 27.7316 27.7316 27.7316 27.731600000000004 21.9372 21.9372 21.9372 21.9372 37.4625 37.4625 37.4625 37.4625 0.0 27.7316 0.0 27.7316 27.7316 21.9372 37.4625 0 1 0 1 65054 AQP9_32709 27.7316 27.7316 21.9372 21.9372 37.4625 37.4625 27.7316 21.9372 37.4625 0 Linear,1(1) 1.8171201944351196 1.8171201944351196 1.8171201944351196 1.8171201944351196 0.0 1.8171201944351196 27.7316 27.7316 21.9372 21.9372 37.4625 37.4625 DOWN 0.0 1.0 0.0 GO:0060964 7 regulation of gene silencing by miRNA 12 14 2 2 2 2 2 2 160 12 2373 0.94527 0.22236 0.22236 14.29 79426;24890 zfp36;esr1 ZFP36_10204;ESR1_33192 11.872667000000002 11.872667000000002 0.348134 16.298150868616293 10.187760182814447 16.123023902822364 9.213451000000001 9.213451000000001 0.118102 12.862765910316568 7.883695118804484 12.724552858802303 16.53761 16.53761 1.15962 21.747762020037833 14.289321051058531 21.514077867395002 0.0 0.348134 0.5 11.872667000000002 0.348134;23.3972 0.118102;18.3088 1.15962;31.9156 0 2 0 2 79426;24890 ZFP36_10204;ESR1_33192 11.872667000000002 11.872667000000002 16.298150868616293 9.213451000000001 9.213451000000001 12.862765910316568 16.53761 16.53761 21.747762020037833 0.348134;23.3972 0.118102;18.3088 1.15962;31.9156 0 Exp 2,1(0.5);Hill,1(0.5) 2.1733176091152004 4.375162720680237 1.9381765127182007 2.436986207962036 0.3527117180285112 2.1875813603401184 -10.715417680000002 34.46075168 -8.613433039999999 27.040335040000002 -13.603250399999997 46.678470399999995 DOWN 0.0 1.0 0.0 GO:0030334 6 regulation of cell migration 259 272 15 15 15 12 12 12 150 260 2125 0.099549 0.94229 0.18879 4.41 83516;85253;25513;307582;24516;24471;24957;25112;294515;25661;361969;24330 ppargc1a;plg;pik3r1;lama3;jun;hspb1;glul;gadd45a;foxo3;fn1;fga;egr1 PPARGC1A_33189;PLG_9501;PIK3R1_32562;LAMA3_8980;JUN_8938;HSPB1_8847;GLUL_32832;GADD45A_8678;FOXO3_8662;FN1_8655;FGA_8632;EGR1_8533 39.28527891666667 27.523600000000002 0.750017 33.96407086075686 49.202487234517946 34.680642306081936 27.15975166666667 21.787300000000002 0.186019 26.66599174418663 34.52233956830398 28.090149828843906 63.567756666666675 40.763400000000004 4.70178 46.538155385786645 76.30564278162167 47.8354055600496 42.4094;70.7857;18.7324;2.46923;16.4324;89.1011;26.4669;102.919;13.1992;59.5777;28.5803;0.750017 26.2988;46.2356;11.6701;0.871501;10.5224;60.3265;21.0456;89.5012;5.6804;31.0499;22.529;0.186019 81.7305;150.579;41.5978;10.4175;39.929;106.138;35.4303;115.437;32.7581;105.243;38.8511;4.70178 0 12 0 12 83516;85253;25513;307582;24516;24471;24957;25112;294515;25661;361969;24330 PPARGC1A_33189;PLG_9501;PIK3R1_32562;LAMA3_8980;JUN_8938;HSPB1_8847;GLUL_32832;GADD45A_8678;FOXO3_8662;FN1_8655;FGA_8632;EGR1_8533 39.28527891666667 27.523600000000002 33.96407086075686 27.15975166666667 21.787300000000002 26.66599174418663 63.567756666666675 40.763400000000004 46.538155385786645 42.4094;70.7857;18.7324;2.46923;16.4324;89.1011;26.4669;102.919;13.1992;59.5777;28.5803;0.750017 26.2988;46.2356;11.6701;0.871501;10.5224;60.3265;21.0456;89.5012;5.6804;31.0499;22.529;0.186019 81.7305;150.579;41.5978;10.4175;39.929;106.138;35.4303;115.437;32.7581;105.243;38.8511;4.70178 0 Exp 2,1(0.09);Exp 4,2(0.17);Hill,1(0.09);Linear,3(0.25);Poly 2,4(0.34);Power,1(0.09) 1.9034525326376746 23.84669840335846 1.5254690647125244 4.21828556060791 0.7398590363342314 1.727470338344574 20.068296771517822 58.5022610618155 12.072046505186465 42.24745682814687 37.23631645788555 89.89919687544779 DOWN 0.0 1.0 0.0 GO:0042180 4 cellular ketone metabolic process 23 27 4 4 3 3 2 2 160 25 2360 0.75576 0.5205 0.6885 7.41 25675;25146 hmgcr;cyp17a1 HMGCR_8810;CYP17A1_32365 25.661545 25.661545 1.63089 33.984478213708826 35.82670293107866 30.79421841726961 18.1642685 18.1642685 0.663137 24.75033752417499 25.567386129131435 22.42692369227379 44.634750000000004 44.634750000000004 7.6286 52.33459922121311 60.2886453753523 47.42173968550762 0.5 25.661545 1.63089;49.6922 0.663137;35.6654 7.6286;81.6409 1 1 1 25146 CYP17A1_32365 49.6922 49.6922 35.6654 35.6654 81.6409 81.6409 49.6922 35.6654 81.6409 1 25675 HMGCR_8810 1.63089 1.63089 0.663137 0.663137 7.6286 7.6286 1.63089 0.663137 7.6286 0 Exp 4,1(0.5);Linear,1(0.5) 1.9055838492314983 3.8111753463745117 1.9017701148986816 1.90940523147583 0.005398842706851482 1.9055876731872559 -21.438538799999993 72.7616288 -16.137949239999998 52.466486239999995 -27.89730399999999 117.16680399999998 CONFLICT 0.5 0.5 0.0 GO:0046474 6 glycerophospholipid biosynthetic process 21 23 4 4 2 4 2 2 160 21 2364 0.82335 0.43545 0.65454 8.7 25513;362866 pik3r1;chpt1 PIK3R1_32562;CHPT1_33298 17.39415 17.39415 16.0559 1.8925712998457698 16.92033321084517 1.7699778037110694 11.136099999999999 11.136099999999999 10.6021 0.7551900423072524 10.94703355844672 0.7062717333694891 35.751400000000004 35.751400000000004 29.905 8.268058171058016 33.68144111629755 7.732485134777997 0.5 17.39415 18.7324;16.0559 11.6701;10.6021 41.5978;29.905 1 1 1 362866 CHPT1_33298 16.0559 16.0559 10.6021 10.6021 29.905 29.905 16.0559 10.6021 29.905 1 25513 PIK3R1_32562 18.7324 18.7324 11.6701 11.6701 41.5978 41.5978 18.7324 11.6701 41.5978 0 Poly 2,2(1) 1.6324096328460995 3.2658320665359497 1.5922520160675049 1.6735800504684448 0.05750760462547745 1.6329160332679749 14.771180000000003 20.01712 10.089459999999999 12.182739999999999 24.29245600000001 47.210344 CONFLICT 0.5 0.5 0.0 GO:0032755 7 positive regulation of interleukin-6 production 35 37 3 3 3 3 3 3 159 34 2351 0.79406 0.42166 0.508 8.11 24539;63868;29184 lpl;hspd1;cd36 LPL_32544;HSPD1_8849;CD36_8243 54.86386666666667 48.1296 42.2579 17.004490120651457 56.308902670014646 17.077212465685587 37.11946666666667 37.5433 23.9469 12.965846460734188 38.637570692613515 12.403847292474062 108.98336666666667 102.383 69.1421 43.51848271945303 109.70045963590708 45.87247732925108 0.5 45.19375 74.2041;42.2579;48.1296 49.8682;23.9469;37.5433 155.425;102.383;69.1421 3 0 3 24539;63868;29184 LPL_32544;HSPD1_8849;CD36_8243 54.86386666666667 48.1296 17.004490120651457 37.11946666666667 37.5433 12.965846460734188 108.98336666666667 102.383 43.51848271945303 74.2041;42.2579;48.1296 49.8682;23.9469;37.5433 155.425;102.383;69.1421 0 0 Exp 2,2(0.67);Exp 3,1(0.34) 2.1087230948900486 6.481560468673706 1.559399127960205 2.6703107357025146 0.5610588990567721 2.2518506050109863 35.62147464742937 74.10625868590395 22.44723017568923 51.79170315764411 59.73756754957809 158.22916578375526 UP 1.0 0.0 0.0 GO:0061024 5 membrane organization 110 116 10 9 5 7 3 3 159 113 2272 0.054259 0.98249 0.11554 2.59 171139;155423;170465 timm9;anxa7;acaa2 TIMM9_10020;ANXA7_8051;ACAA2_7955 171139(0.04986) 56.582100000000004 38.5191 26.5872 42.04478414393394 55.12762822406466 45.06136595150555 31.614966666666664 29.55 21.3695 11.418853782378216 29.973607865951372 12.914282961192622 66.3994 55.4685 35.0407 38.021460444464786 62.661180784504985 42.23913026900274 38.5191;104.64;26.5872 29.55;43.9254;21.3695 55.4685;108.689;35.0407 3 0 3 171139;155423;170465 TIMM9_10020;ANXA7_8051;ACAA2_7955 56.582100000000004 38.5191 42.04478414393394 31.614966666666664 29.55 11.418853782378216 66.3994 55.4685 38.021460444464786 38.5191;104.64;26.5872 29.55;43.9254;21.3695 55.4685;108.689;35.0407 0 0 Exp 2,2(0.67);Exp 3,1(0.34) 1.921998563267154 6.000198841094971 1.5461770296096802 2.8333094120025635 0.7225714273733916 1.620712399482727 9.003947810700843 104.16025218929917 18.693317188684304 44.53661614464903 23.374067171714884 109.42473282828512 UP 1.0 0.0 0.0 GO:0006366 8 transcription by RNA polymerase II 35 40 5 5 5 4 4 4 158 36 2349 0.8935 0.24762 0.31829 10.0 24516;314322;24890;24330 jun;fos;esr1;egr1 JUN_8938;FOS_8657;ESR1_33192;EGR1_8533 10.144904250000321 8.5912085 1.28141E-12 11.638140374555704 7.368159580647685 10.417721223806593 7.254304750000321 5.3542095 1.28141E-12 8.859418954702996 4.991974259341352 7.673659067570168 19.13659500000032 18.308690000000002 1.28142E-12 19.750107398461164 16.155077828009347 19.255704635775803 1.0 0.750017 3.0 23.3972 16.4324;1.28141E-12;23.3972;0.750017 10.5224;1.28141E-12;18.3088;0.186019 39.929;1.28142E-12;31.9156;4.70178 0 4 0 4 24516;314322;24890;24330 JUN_8938;FOS_8657;ESR1_33192;EGR1_8533 10.144904250000321 8.5912085 11.638140374555704 7.254304750000321 5.3542095 8.859418954702996 19.13659500000032 18.308690000000002 19.750107398461164 16.4324;1.28141E-12;23.3972;0.750017 10.5224;1.28141E-12;18.3088;0.186019 39.929;1.28142E-12;31.9156;4.70178 0 Exp 2,1(0.25);Hill,2(0.5);Poly 2,1(0.25) 2.4921801755766153 10.53044581413269 1.8966681957244873 4.21828556060791 1.083527915353543 2.2077460289001465 -1.2604733170642657 21.550281817064914 -1.4279258256086163 15.936535325609258 -0.21851025049162232 38.49170025049226 DOWN 0.0 1.0 0.0 GO:0043536 8 positive regulation of blood vessel endothelial cell migration 22 23 3 3 3 2 2 2 160 21 2364 0.82335 0.43545 0.65454 8.7 85253;24471 plg;hspb1 PLG_9501;HSPB1_8847 79.9434 79.9434 70.7857 12.950943540144198 79.36736213013745 12.925296875699551 53.28105 53.28105 46.2356 9.963770943021554 52.837876931410385 9.944039755931879 128.3585 128.3585 106.138 31.424532462711383 129.75621443564222 31.362302677144047 0.5 79.9434 70.7857;89.1011 46.2356;60.3265 150.579;106.138 0 2 0 2 85253;24471 PLG_9501;HSPB1_8847 79.9434 79.9434 12.950943540144198 53.28105 53.28105 9.963770943021554 128.3585 128.3585 31.424532462711383 70.7857;89.1011 46.2356;60.3265 150.579;106.138 0 Linear,1(0.5);Poly 2,1(0.5) 1.609100833438926 3.2227866649627686 1.5254690647125244 1.6973176002502441 0.12151526481569902 1.6113933324813843 61.994308000000004 97.89249199999999 39.471968 67.09013200000001 84.80632 171.91067999999999 DOWN 0.0 1.0 0.0 GO:0012501 4 programmed cell death 149 161 10 10 9 9 8 8 154 153 2232 0.2907 0.81822 0.61526 4.97 246273;24825;25591;294515;29496;140942;25423;246142 trib3;tf;parp1;foxo3;erbb3;ddit4;ctsc;bmf TRIB3_10079;TF_10003;PARP1_9425;FOXO3_8662;ERBB3_8571;DDIT4_8450;CTSC_32456;BMF_8152 61.630875 58.6185 13.1992 33.33894786743961 62.501120028780754 29.961292450299407 43.218275000000006 39.93585 5.6804 26.10899395833605 45.0309792669632 23.97593010723451 105.6499875 106.368 32.7581 68.9605380121836 94.92884407160301 49.869796647264685 108.064;45.1539;26.9741;13.1992;60.9984;87.5421;56.2386;94.8767 83.8836;28.132;21.799;5.6804;41.6036;53.2453;38.2681;73.1342 143.428;61.5341;35.2797;32.7581;113.972;245.492;102.888;109.848 4 4 4 24825;25591;29496;246142 TF_10003;PARP1_9425;ERBB3_8571;BMF_8152 57.000775 53.07615 28.824274255492252 41.1672 34.8678 22.85551096373331 80.15845 85.69105 38.235211334100555 45.1539;26.9741;60.9984;94.8767 28.132;21.799;41.6036;73.1342 61.5341;35.2797;113.972;109.848 4 246273;294515;140942;25423 TRIB3_10079;FOXO3_8662;DDIT4_8450;CTSC_32456 66.260975 71.89035 41.29721196080713 45.26935 45.756699999999995 32.51142642789864 131.141525 123.158 88.8904730371549 108.064;13.1992;87.5421;56.2386 83.8836;5.6804;53.2453;38.2681 143.428;32.7581;245.492;102.888 0 Exp 2,2(0.25);Exp 4,1(0.13);Linear,2(0.25);Poly 2,3(0.38) 1.7513470487729363 14.051956534385681 1.5736411809921265 1.9883413314819336 0.14425194020245774 1.754923701286316 38.52816280760249 84.73358719239752 25.125665255659936 61.31088474434006 57.86277271856606 153.43720228143394 CONFLICT 0.5 0.5 0.0 GO:0010565 6 regulation of cellular ketone metabolic process 51 56 9 9 7 9 7 7 155 49 2336 0.9767 0.061586 0.085775 12.5 246273;25106;83516;24360;24330;25428;25287 trib3;rgn;ppargc1a;fabp1;egr1;cyp7a1;acadl TRIB3_10079;RGN_9699;PPARGC1A_33189;FABP1_33091;EGR1_8533;CYP7A1_8430;ACADL_32776 43.102999571428576 33.8478 0.750017 38.22906660401805 44.816665776906795 37.545999778113035 31.886341714285713 26.4736 0.186019 30.20713798459318 33.23410732327843 29.358747987578116 62.03942571428571 46.9257 4.70178 46.81965971928847 63.628965646623016 46.94974952088583 1.5 19.60454 4.5 59.92505 108.064;77.4407;42.4094;33.8478;0.750017;5.72128;33.4878 83.8836;58.7732;26.2988;26.4736;0.186019;0.985273;26.6039 143.428;89.8047;81.7305;46.9257;4.70178;22.3625;45.3228 3 4 3 25106;24360;25287 RGN_9699;FABP1_33091;ACADL_32776 48.258766666666666 33.8478 25.27293660822451 37.283566666666665 26.6039 18.610682419603357 60.684400000000004 46.9257 25.23165127711622 77.4407;33.8478;33.4878 58.7732;26.4736;26.6039 89.8047;46.9257;45.3228 4 246273;83516;24330;25428 TRIB3_10079;PPARGC1A_33189;EGR1_8533;CYP7A1_8430 39.23617425 24.06534 49.503438922944994 27.838423 13.6420365 39.28179992415985 63.055695 52.0465 62.90090425406273 108.064;42.4094;0.750017;5.72128 83.8836;26.2988;0.186019;0.985273 143.428;81.7305;4.70178;22.3625 0 Exp 2,3(0.43);Hill,2(0.29);Poly 2,2(0.29) 2.341884295644506 17.89582908153534 1.7198865413665771 4.560328960418701 1.2575390139195337 1.87713623046875 14.78251070668881 71.42348843616834 9.508580734936736 54.264102693634705 27.354936410232206 96.72391501833926 CONFLICT 0.42857142857142855 0.5714285714285714 0.0 GO:0071371 6 cellular response to gonadotropin stimulus 23 25 6 6 6 6 6 6 156 19 2366 0.99933 0.0038784 0.0038784 24.0 24825;83516;29441;81819;24330;25146 tf;ppargc1a;por;pax8;egr1;cyp17a1 TF_10003;PPARGC1A_33189;POR_9531;PAX8_9432;EGR1_8533;CYP17A1_32365 34.5566695 43.78165 0.750017 22.51196117572571 34.37108866149017 23.170503957788878 23.981371499999998 27.215400000000002 0.186019 16.804778890651242 24.04487044457717 17.571925116179557 65.06859666666666 80.40215 4.70178 30.60020699835977 63.7962784798311 31.015108131396243 0.5 6.5957085 1.5 27.4254 45.1539;42.4094;12.4414;56.8931;0.750017;49.6922 28.132;26.2988;8.48981;45.1162;0.186019;35.6654 61.5341;81.7305;79.2355;81.5688;4.70178;81.6409 3 3 3 24825;81819;25146 TF_10003;PAX8_9432;CYP17A1_32365 50.57973333333334 49.6922 5.919712047332406 36.30453333333333 35.6654 8.510119327796374 74.91460000000001 81.5688 11.587908991271828 45.1539;56.8931;49.6922 28.132;45.1162;35.6654 61.5341;81.5688;81.6409 3 83516;29441;24330 PPARGC1A_33189;POR_9531;EGR1_8533 18.533605666666666 12.4414 21.487491137843342 11.658209666666666 8.48981 13.341604109862141 55.22259333333333 79.2355 43.77008900089345 42.4094;12.4414;0.750017 26.2988;8.48981;0.186019 81.7305;79.2355;4.70178 0 Exp 2,2(0.34);Hill,1(0.17);Linear,1(0.17);Poly 2,2(0.34) 2.117663581545542 13.453911185264587 1.7521979808807373 4.21828556060791 0.9720666026680156 1.8719382286071777 16.543348956641402 52.569990043358594 10.534747882686103 37.4279951173139 40.583331564622064 89.55386176871127 CONFLICT 0.5 0.5 0.0 GO:0030212 7 hyaluronan metabolic process 14 14 4 4 3 3 3 3 159 11 2374 0.99046 0.054735 0.054735 21.43 54404;50693;306251 itih4;itih3;itih1 ITIH4_32725;ITIH3_32422;ITIH1_33132 60.805033333333334 57.1163 27.1247 35.668044175330564 70.3294396805247 30.97012655143491 34.686033333333334 39.6402 21.5108 11.526414834775538 38.685573902464824 8.251949996914929 80.8763 101.869 36.4819 38.46554151146192 94.53686586797843 27.205543737989302 0.0 27.1247 0.5 42.1205 57.1163;27.1247;98.1741 39.6402;21.5108;42.9071 101.869;36.4819;104.278 0 3 0 3 54404;50693;306251 ITIH4_32725;ITIH3_32422;ITIH1_33132 60.805033333333334 57.1163 35.668044175330564 34.686033333333334 39.6402 11.526414834775538 80.8763 101.869 38.46554151146192 57.1163;27.1247;98.1741 39.6402;21.5108;42.9071 101.869;36.4819;104.278 0 Exp 3,1(0.34);Linear,2(0.67) 1.5792794451039143 4.7396000623703 1.5197933912277222 1.616459846496582 0.052436519005178005 1.603346824645996 20.44284171738797 101.16722494927868 21.6426670663414 47.729399600325266 37.34844213751216 124.40415786248784 DOWN 0.0 1.0 0.0 GO:1901135 4 carbohydrate derivative metabolic process 159 175 31 31 21 27 19 19 143 156 2229 0.99377 0.013084 0.01595 10.86 360268;298490;24651;25591;294103;100359982;54404;50693;306251;25675;83842;361239;25028;192272;170570;50559;170465;312382;296925 sult1e1;ppcs;pklr;parp1;papss2;mpc2;itih4;itih3;itih1;hmgcr;crot;bphl;ampd1;acot2;acot12;acot1;acaa2;abcg2;aass SULT1E1_32446;PPCS_9540;PKLR_9489;PARP1_9425;PAPSS2_33237;MPC2_33219;ITIH4_32725;ITIH3_32422;ITIH1_33132;HMGCR_8810;CROT_8384;BPHL_8157;AMPD1_32743;ACOT2_7969;ACOT12_32718;ACOT1_7968;ACAA2_7955;ABCG2_32656;AASS_7936 31.364777894736836 27.1247 1.63089 23.444311952036138 35.540962840255986 24.627295639359673 22.377181421052637 21.7498 0.663137 14.086704137436971 24.851685628335396 13.840711733549439 44.00455263157895 36.4819 7.6286 30.084032300344752 49.303482611323794 30.92102973463704 7.5 26.78065 16.5 59.010400000000004 50.1846;20.3353;23.0963;26.9741;34.4443;46.8463;57.1163;27.1247;98.1741;1.63089;7.4229;12.3152;60.9045;8.54905;30.3423;31.2018;26.5872;5.21654;27.4644 36.5009;16.7643;17.4625;21.799;25.719;35.8494;39.6402;21.5108;42.9071;0.663137;5.75707;6.6063;50.0633;7.19676;24.0157;26.858;21.3695;2.73368;21.7498 80.9788;25.6711;32.9443;35.2797;51.1014;69.127;101.869;36.4819;104.278;7.6286;10.316;25.5051;82.6625;10.4125;41.1025;37.2719;35.0407;11.386;37.0295 13 6 13 360268;298490;25591;100359982;83842;361239;25028;192272;170570;50559;170465;312382;296925 SULT1E1_32446;PPCS_9540;PARP1_9425;MPC2_33219;CROT_8384;BPHL_8157;AMPD1_32743;ACOT2_7969;ACOT12_32718;ACOT1_7968;ACAA2_7955;ABCG2_32656;AASS_7936 27.25724538461538 26.9741 17.24226900481132 21.32797769230769 21.7498 13.935751020541943 38.59871538461539 35.2797 24.794664425027882 50.1846;20.3353;26.9741;46.8463;7.4229;12.3152;60.9045;8.54905;30.3423;31.2018;26.5872;5.21654;27.4644 36.5009;16.7643;21.799;35.8494;5.75707;6.6063;50.0633;7.19676;24.0157;26.858;21.3695;2.73368;21.7498 80.9788;25.6711;35.2797;69.127;10.316;25.5051;82.6625;10.4125;41.1025;37.2719;35.0407;11.386;37.0295 6 24651;294103;54404;50693;306251;25675 PKLR_9489;PAPSS2_33237;ITIH4_32725;ITIH3_32422;ITIH1_33132;HMGCR_8810 40.26443166666667 30.7845 33.55990739058761 24.650456166666668 23.6149 15.46644681672065 55.7172 43.791650000000004 39.269735777007725 23.0963;34.4443;57.1163;27.1247;98.1741;1.63089 17.4625;25.719;39.6402;21.5108;42.9071;0.663137 32.9443;51.1014;101.869;36.4819;104.278;7.6286 0 Exp 2,10(0.53);Exp 3,1(0.06);Exp 4,3(0.16);Linear,4(0.22);Poly 2,1(0.06) 2.8591514691538173 392.13638651371 1.5074360370635986 344.14306640625 78.37811406866531 1.8086696863174438 20.82292959286601 41.90662619660767 16.043026748737773 28.711336093367493 30.477121949559155 57.53198331359872 UP 0.6842105263157895 0.3157894736842105 0.0 GO:0000187 10 activation of MAPK activity 35 38 2 2 2 2 2 2 160 36 2349 0.56102 0.70748 1.0 5.26 24825;29455 tf;gdf15 TF_10003;GDF15_33113 75.15145 75.15145 45.1539 42.42294204796505 75.34107866325733 42.42209440781001 56.74035 56.74035 28.132 40.45831656711633 56.92119687477803 40.457508181557166 93.59305 93.59305 61.5341 45.33820188544094 93.79570974501031 45.33729599634831 0.5 75.15145 45.1539;105.149 28.132;85.3487 61.5341;125.652 1 1 1 24825 TF_10003 45.1539 45.1539 28.132 28.132 61.5341 61.5341 45.1539 28.132 61.5341 1 29455 GDF15_33113 105.149 105.149 85.3487 85.3487 125.652 125.652 105.149 85.3487 125.652 0 Poly 2,2(1) 1.6920131372954912 3.395089030265808 1.5606178045272827 1.8344712257385254 0.1936436111896056 1.697544515132904 16.356252000000005 133.94664799999998 0.6679840000000041 112.81271599999998 30.757508000000016 156.42859199999998 CONFLICT 0.5 0.5 0.0 GO:0002250 4 adaptive immune response 53 57 4 4 4 4 4 4 158 53 2332 0.70503 0.49592 0.78169 7.02 63868;246186;361969;25423 hspd1;fgl1;fga;ctsc HSPD1_8849;FGL1_8640;FGA_8632;CTSC_32456 35.638124999999995 35.4191 15.4757 17.555030303662267 33.64204943118041 17.891584477654117 23.739449999999998 23.237949999999998 10.2138 11.482350274080071 22.761304984376423 11.781304697213164 68.633175 70.61705 30.4106 39.41396095398813 63.096875475533174 39.04577529990343 1.5 35.4191 42.2579;15.4757;28.5803;56.2386 23.9469;10.2138;22.529;38.2681 102.383;30.4106;38.8511;102.888 1 3 1 63868 HSPD1_8849 42.2579 42.2579 23.9469 23.9469 102.383 102.383 42.2579 23.9469 102.383 3 246186;361969;25423 FGL1_8640;FGA_8632;CTSC_32456 33.431533333333334 28.5803 20.80995801877873 23.670299999999997 22.529 14.061929504516803 57.38323333333333 38.8511 39.63361391676683 15.4757;28.5803;56.2386 10.2138;22.529;38.2681 30.4106;38.8511;102.888 0 Exp 2,1(0.25);Exp 3,1(0.25);Linear,1(0.25);Poly 2,1(0.25) 1.695174138798229 6.878709435462952 1.511321783065796 2.2518506050109863 0.3556933296127873 1.5577685236930847 18.434195302410995 52.842054697589006 12.48674673140153 34.992153268598464 30.00749326509164 107.25885673490835 DOWN 0.25 0.75 0.0 GO:0044248 4 cellular catabolic process 306 344 55 55 40 49 35 35 127 309 2076 0.99885 0.002265 0.0040156 10.17 79426;312688;286954;360268;65192;29676;83516;29441;24539;24443;171155;113965;85255;81869;308441;295143;65030;25315;171142;291075;29740;65210;24894;83842;497840;81718;29184;155423;50681;192272;24158;25287;170465;25303;296925 zfp36;usp18;ugt2b1;sult1e1;slc27a2;psmb3;ppargc1a;por;lpl;hdc;hadhb;hadh;hacl1;gstm7;exosc5;etfdh;ephx2;ephx1;ehhadh;eci2;eci1;cyp2j4;cyp2a1;crot;cps1;cdo1;cd36;anxa7;acox1;acot2;acadm;acadl;acaa2;abcc2;aass ZFP36_10204;USP18_10138;UGT2B10_33303,UGT2B1_33224;SULT1E1_32446;SLC27A2_9860;PSMB3_9589;PPARGC1A_33189;POR_9531;LPL_32544;HDC_8788;HADHB_8777;HADH_8776;HACL1_8775;GSTM7_8761;EXOSC5_32543;ETFDH_8575;EPHX2_33282;EPHX1_8567;EHHADH_8534;ECI2_8521;ECI1_8520;CYP2J4_32580;CYP2A1_32717;CROT_8384;CPS1_32421;CDO1_8275;CD36_8243;ANXA7_8051;ACOX1_7973;ACOT2_7969;ACADM_7957;ACADL_32776;ACAA2_7955;ABCC2_32541;AASS_7936 32.1447404 26.5872 0.348134 24.953995841735754 32.9120170200473 24.516291156888123 22.615986342857145 21.3695 0.118102 15.20255941999345 23.11303627261234 14.873526676665579 49.48101057142856 37.6534 1.15962 36.72049834064596 52.30604017914426 38.47728184096996 16.5 25.580849999999998 33.5 106.7615 0.348134;108.883;47.47345;50.1846;7.62189;23.7888;42.4094;12.4414;74.2041;24.5745;31.8029;33.3125;17.6275;42.3152;41.9329;18.1231;38.7293;12.4747;8.62809;10.6467;11.9473;17.8395;55.3937;7.4229;31.9826;22.9638;48.1296;104.64;23.1906;8.54905;11.7137;33.4878;26.5872;46.2316;27.4644 0.118102;73.1414;34.82915;36.5009;5.49916;19.2724;26.2988;8.48981;49.8682;21.0619;25.5756;25.7336;11.195;31.4035;31.7336;14.869;29.2097;7.00435;7.31865;8.92359;7.15307;14.6501;38.7444;5.75707;24.4836;18.5144;37.5433;43.9254;16.2815;7.19676;8.36151;26.6039;21.3695;31.1788;21.7498 1.15962;138.144;76.47475;80.9788;13.3925;30.901;81.7305;79.2355;155.425;29.28;42.1484;46.9856;37.6534;64.5991;62.1373;23.0103;57.2113;23.684;10.3909;13.0581;19.001;22.6149;96.8569;10.316;45.5891;30.0179;69.1421;108.689;33.4539;10.4125;18.9642;45.3228;35.0407;81.7848;37.0295 30 6 29 312688;286954;360268;65192;29676;24539;24443;171155;113965;85255;81869;308441;295143;65030;25315;171142;291075;29740;65210;24894;83842;29184;155423;50681;192272;24158;25287;170465;296925 USP18_10138;UGT2B10_33303,UGT2B1_33224;SULT1E1_32446;SLC27A2_9860;PSMB3_9589;LPL_32544;HDC_8788;HADHB_8777;HADH_8776;HACL1_8775;GSTM7_8761;EXOSC5_32543;ETFDH_8575;EPHX2_33282;EPHX1_8567;EHHADH_8534;ECI2_8521;ECI1_8520;CYP2J4_32580;CYP2A1_32717;CROT_8384;CD36_8243;ANXA7_8051;ACOX1_7973;ACOT2_7969;ACADM_7957;ACADL_32776;ACAA2_7955;AASS_7936 33.403068275862076 26.5872 26.280480261702117 23.533655517241378 21.3695 15.834732068527305 48.700618965517236 37.0295 37.85779697746371 108.883;47.47345;50.1846;7.62189;23.7888;74.2041;24.5745;31.8029;33.3125;17.6275;42.3152;41.9329;18.1231;38.7293;12.4747;8.62809;10.6467;11.9473;17.8395;55.3937;7.4229;48.1296;104.64;23.1906;8.54905;11.7137;33.4878;26.5872;27.4644 73.1414;34.82915;36.5009;5.49916;19.2724;49.8682;21.0619;25.5756;25.7336;11.195;31.4035;31.7336;14.869;29.2097;7.00435;7.31865;8.92359;7.15307;14.6501;38.7444;5.75707;37.5433;43.9254;16.2815;7.19676;8.36151;26.6039;21.3695;21.7498 138.144;76.47475;80.9788;13.3925;30.901;155.425;29.28;42.1484;46.9856;37.6534;64.5991;62.1373;23.0103;57.2113;23.684;10.3909;13.0581;19.001;22.6149;96.8569;10.316;69.1421;108.689;33.4539;10.4125;18.9642;45.3228;35.0407;37.0295 6 79426;83516;29441;497840;81718;25303 ZFP36_10204;PPARGC1A_33189;POR_9531;CPS1_32421;CDO1_8275;ABCC2_32541 26.062822333333333 27.4732 17.69421511957263 18.180585333333333 21.499 11.78866278033954 53.252903333333336 62.4123 33.50357413389902 0.348134;42.4094;12.4414;31.9826;22.9638;46.2316 0.118102;26.2988;8.48981;24.4836;18.5144;31.1788 1.15962;81.7305;79.2355;45.5891;30.0179;81.7848 0 Exp 2,15(0.42);Exp 3,1(0.03);Hill,4(0.12);Linear,10(0.28);Poly 2,4(0.12);Power,2(0.06) 2.7006296459055346 148.98676681518555 1.5461770296096802 32.73371124267578 6.035311585704765 1.9334938526153564 23.877469902816696 40.41201089718331 17.579371294441483 27.6526013912728 37.31549229135601 61.64652885150113 UP 0.8285714285714286 0.17142857142857143 0.0 GO:0097066 5 response to thyroid hormone 22 25 3 3 3 2 2 2 160 23 2362 0.79018 0.47902 0.67089 8.0 83516;361969 ppargc1a;fga PPARGC1A_33189;FGA_8632 35.49485 35.49485 28.5803 9.778650387706872 33.77503507995917 9.471350309570953 24.413899999999998 24.413899999999998 22.529 2.665651143717065 23.945080027220143 2.581881423738395 60.290800000000004 60.290800000000004 38.8511 30.32031451321045 54.95823086083702 29.367480057575477 0.5 35.49485 42.4094;28.5803 26.2988;22.529 81.7305;38.8511 0 2 0 2 83516;361969 PPARGC1A_33189;FGA_8632 35.49485 35.49485 9.778650387706872 24.413899999999998 24.413899999999998 2.665651143717065 60.290800000000004 60.290800000000004 30.32031451321045 42.4094;28.5803 26.2988;22.529 81.7305;38.8511 0 Exp 2,1(0.5);Linear,1(0.5) 1.6462295575769277 3.2995189428329468 1.541895866394043 1.7576230764389038 0.15254217310917578 1.6497594714164734 21.942332000000004 49.04736799999999 20.719496 28.108303999999997 18.268988000000007 102.312612 DOWN 0.0 1.0 0.0 GO:0032874 8 positive regulation of stress-activated MAPK cascade 40 44 4 4 4 4 4 4 158 40 2345 0.85591 0.30563 0.35972 9.09 24825;25675;299626;25112 tf;hmgcr;gadd45b;gadd45a TF_10003;HMGCR_8810;GADD45B_8679;GADD45A_8678 64.0176975 74.03645 1.63089 50.18210625510543 75.97047684410246 38.539983650086576 42.75238425 40.4226 0.663137 37.72678091277767 57.78314577116053 36.356686474815476 73.508425 85.48405 7.6286 50.107178932921705 88.5436218562243 37.26276685088905 1.5 74.03645 45.1539;1.63089;106.367;102.919 28.132;0.663137;52.7132;89.5012 61.5341;7.6286;109.434;115.437 2 2 2 24825;299626 TF_10003;GADD45B_8679 75.76045 75.76045 43.28419810745022 40.4226 40.4226 17.38153320970276 85.48405 85.48405 33.8703441081575 45.1539;106.367 28.132;52.7132 61.5341;109.434 2 25675;25112 HMGCR_8810;GADD45A_8678 52.274944999999995 52.274944999999995 71.62150943456895 45.0821685 45.0821685 62.81799677477772 61.5328 61.5328 76.23205070887178 1.63089;102.919 0.663137;89.5012 7.6286;115.437 0 Exp 4,1(0.25);Poly 2,2(0.5);Power,1(0.25) 1.724847350552747 6.9229185581207275 1.5527137517929077 1.9017701148986816 0.16438826966437828 1.734217345714569 14.839233369996677 113.19616163000332 5.780138955477881 79.72462954452212 24.403389645736723 122.61346035426328 CONFLICT 0.5 0.5 0.0 GO:0051707 4 response to other organism 231 253 25 25 19 21 16 16 146 237 2148 0.5565 0.55144 1.0 6.32 312688;25357;24825;29500;246074;24651;25513;24539;24471;24464;361969;308441;140942;29184;54232;313421 usp18;thrsp;tf;slc10a2;scd;pklr;pik3r1;lpl;hspb1;hp;fga;exosc5;ddit4;cd36;car3;c8b USP18_10138;THRSP_33314;TF_10003;SLC10A2_9833;SCD1_9787;PKLR_9489;PIK3R1_32562;LPL_32544;HSPB1_8847;HP_8823;FGA_8632;EXOSC5_32543;DDIT4_8450;CD36_8243;CAR3_8196;C8B_8181 56.241181250000004 51.0461 18.7324 29.569110621011667 55.715252046294374 26.515258841750786 37.275237499999996 33.5066 11.6701 18.222132423324304 37.10997553045621 16.562263003960904 111.1819625 73.08545000000001 27.9161 101.18110935325085 102.77438421181066 86.58124510336644 11.5 80.8731 108.883;32.2053;45.1539;56.585;105.46;23.0963;18.7324;74.2041;89.1011;64.9285;28.5803;41.9329;87.5421;48.1296;53.9626;21.3618 73.1414;24.3966;28.132;35.2796;63.7532;17.4625;11.6701;49.8682;60.3265;41.6103;22.529;31.7336;53.2453;37.5433;28.5034;17.2088 138.144;46.6068;61.5341;116.8;422.699;32.9443;41.5978;155.425;106.138;136.455;38.8511;62.1373;245.492;69.1421;77.0288;27.9161 6 10 6 312688;24825;246074;24539;308441;29184 USP18_10138;TF_10003;SCD1_9787;LPL_32544;EXOSC5_32543;CD36_8243 70.62724999999999 61.16685 30.554928486956086 47.36195 43.70575 18.165773291963117 151.51358333333334 103.64305 139.00004594349483 108.883;45.1539;105.46;74.2041;41.9329;48.1296 73.1414;28.132;63.7532;49.8682;31.7336;37.5433 138.144;61.5341;422.699;155.425;62.1373;69.1421 10 25357;29500;24651;25513;24471;24464;361969;140942;54232;313421 THRSP_33314;SLC10A2_9833;PKLR_9489;PIK3R1_32562;HSPB1_8847;HP_8823;FGA_8632;DDIT4_8450;CAR3_8196;C8B_8181 47.60954 43.08395 26.791707088375933 31.22321 26.45 16.172658928536702 86.98299 61.817800000000005 67.77696179629591 32.2053;56.585;23.0963;18.7324;89.1011;64.9285;28.5803;87.5421;53.9626;21.3618 24.3966;35.2796;17.4625;11.6701;60.3265;41.6103;22.529;53.2453;28.5034;17.2088 46.6068;116.8;32.9443;41.5978;106.138;136.455;38.8511;245.492;77.0288;27.9161 0 Exp 2,9(0.57);Linear,2(0.13);Poly 2,4(0.25);Power,1(0.07) 1.9400443938625342 32.38088369369507 1.5122476816177368 3.910295248031616 0.676785663731068 1.6854488253593445 41.75231704570429 70.73004545429572 28.346392612571094 46.20408238742891 61.60321891690711 160.7607060830929 DOWN 0.375 0.625 0.0 GO:0060627 5 regulation of vesicle-mediated transport 135 149 8 7 5 6 4 4 158 145 2240 0.03257 0.98887 0.056977 2.68 24825;361969;29184;25373 tf;fga;cd36;ahsg TF_10003;FGA_8632;CD36_8243;AHSG_8003 33.56645 36.8671 12.402 16.524224349421058 36.63161445741161 14.317874812072361 24.6264 25.3305 10.3013 11.383366721376118 27.001132572722526 10.098078160927914 46.237700000000004 50.1926 15.4235 24.23955564444199 50.80365735934506 21.181917831218865 45.1539;28.5803;48.1296;12.402 28.132;22.529;37.5433;10.3013 61.5341;38.8511;69.1421;15.4235 2 2 2 24825;29184 TF_10003;CD36_8243 46.64175 46.64175 2.1041376487768804 32.837650000000004 32.837650000000004 6.654794049780926 65.3381 65.3381 5.379668391267444 45.1539;48.1296 28.132;37.5433 61.5341;69.1421 2 361969;25373 FGA_8632;AHSG_8003 20.49115 20.49115 11.43978563807032 16.41515 16.41515 8.646289588314747 27.137300000000003 27.137300000000003 16.565814826925955 28.5803;12.402 22.529;10.3013 38.8511;15.4235 0 Exp 2,2(0.5);Linear,1(0.25);Poly 2,1(0.25) 2.256318528927674 9.478097915649414 1.541895866394043 3.431420087814331 0.8542727434237106 2.25239098072052 17.37271013756736 49.76018986243265 13.4707006130514 35.7820993869486 22.482935468446836 69.99246453155315 CONFLICT 0.5 0.5 0.0 GO:0071840 3 cellular component organization or biogenesis 813 886 50 49 39 44 34 34 128 852 1533 5.6973E-5 0.99997 1.1223E-4 3.84 257644;24522;296554;308843;171139;24825;29482;293615;297784;308821;83516;298699;303612;85253;25591;24539;307582;24516;306251;63868;85255;29328;24957;25112;25661;361969;29496;140942;29184;155423;25373;50681;170465;312382 zwint;zfp354a;tubb4b;tsku;timm9;tf;slc1a2;sirt3;rrs1;rab30;ppargc1a;ppan;polg2;plg;parp1;lpl;lama3;jun;itih1;hspd1;hacl1;gpx4;glul;gadd45a;fn1;fga;erbb3;ddit4;cd36;anxa7;ahsg;acox1;acaa2;abcg2 ZWINT_10214;ZFP354A_10203;TUBB4B_34097;TSKU_10094;TIMM9_10020;TF_10003;SLC1A2_33059;SIRT3_9828;RRS1_9755;RAB30_9639;PPARGC1A_33189;PPAN_9534;POLG2_9521;PLG_9501;PARP1_9425;LPL_32544;LAMA3_8980;JUN_8938;ITIH1_33132;HSPD1_8849;HACL1_8775;GPX4_32827;GLUL_32832;GADD45A_8678;FN1_8655;FGA_8632;ERBB3_8571;DDIT4_8450;CD36_8243;ANXA7_8051;AHSG_8003;ACOX1_7973;ACAA2_7955;ABCG2_32656 171139(0.04986) 42.59224814705883 42.33365 0.834827 29.802351878562533 44.84653075019195 30.15686365618589 28.223367911764708 27.215400000000002 0.27095 19.355928517924283 29.840033983223876 20.3371794355812 71.37381647058824 65.3381 2.99857 53.54620588145061 72.29183844519096 48.886058099189135 52.0003;0.834827;62.7603;1.38416;38.5191;45.1539;13.3235;2.38018;60.39;26.4203;42.4094;57.6889;63.7758;70.7857;26.9741;74.2041;2.46923;16.4324;98.1741;42.2579;17.6275;45.9204;26.4669;102.919;59.5777;28.5803;60.9984;87.5421;48.1296;104.64;12.402;23.1906;26.5872;5.21654 38.9015;0.27095;47.0916;0.540568;29.55;28.132;9.10952;0.56209;43.109;21.0125;26.2988;41.3659;40.9553;46.2356;21.799;49.8682;0.871501;10.5224;42.9071;23.9469;11.195;34.2198;21.0456;89.5012;31.0499;22.529;41.6036;53.2453;37.5433;43.9254;10.3013;16.2815;21.3695;2.73368 80.8613;2.99857;101.528;4.10872;55.4685;61.5341;24.6773;8.82917;104.942;35.3561;81.7305;98.1741;132.567;150.579;35.2797;155.425;10.4175;39.929;104.278;102.383;37.6534;70.4292;35.4303;115.437;105.243;38.8511;113.972;245.492;69.1421;108.689;15.4235;33.4539;35.0407;11.386 19 15 19 257644;296554;171139;24825;293615;297784;308821;298699;25591;24539;63868;85255;29328;29496;29184;155423;50681;170465;312382 ZWINT_10214;TUBB4B_34097;TIMM9_10020;TF_10003;SIRT3_9828;RRS1_9755;RAB30_9639;PPAN_9534;PARP1_9425;LPL_32544;HSPD1_8849;HACL1_8775;GPX4_32827;ERBB3_8571;CD36_8243;ANXA7_8051;ACOX1_7973;ACAA2_7955;ABCG2_32656 43.21364842105263 45.1539 24.78894574867714 29.16897210526316 29.55 14.666663490351391 69.44985631578948 69.1421 39.69915998528225 52.0003;62.7603;38.5191;45.1539;2.38018;60.39;26.4203;57.6889;26.9741;74.2041;42.2579;17.6275;45.9204;60.9984;48.1296;104.64;23.1906;26.5872;5.21654 38.9015;47.0916;29.55;28.132;0.56209;43.109;21.0125;41.3659;21.799;49.8682;23.9469;11.195;34.2198;41.6036;37.5433;43.9254;16.2815;21.3695;2.73368 80.8613;101.528;55.4685;61.5341;8.82917;104.942;35.3561;98.1741;35.2797;155.425;102.383;37.6534;70.4292;113.972;69.1421;108.689;33.4539;35.0407;11.386 15 24522;308843;29482;83516;303612;85253;307582;24516;306251;24957;25112;25661;361969;140942;25373 ZFP354A_10203;TSKU_10094;SLC1A2_33059;PPARGC1A_33189;POLG2_9521;PLG_9501;LAMA3_8980;JUN_8938;ITIH1_33132;GLUL_32832;GADD45A_8678;FN1_8655;FGA_8632;DDIT4_8450;AHSG_8003 41.80514113333333 28.5803 36.08765440251956 27.025602599999996 22.529 24.572062885872224 73.81083266666666 39.929 68.70726589161923 0.834827;1.38416;13.3235;42.4094;63.7758;70.7857;2.46923;16.4324;98.1741;26.4669;102.919;59.5777;28.5803;87.5421;12.402 0.27095;0.540568;9.10952;26.2988;40.9553;46.2356;0.871501;10.5224;42.9071;21.0456;89.5012;31.0499;22.529;53.2453;10.3013 2.99857;4.10872;24.6773;81.7305;132.567;150.579;10.4175;39.929;104.278;35.4303;115.437;105.243;38.8511;245.492;15.4235 0 Exp 2,13(0.39);Exp 3,3(0.09);Exp 4,2(0.06);Hill,3(0.09);Linear,6(0.18);Poly 2,5(0.15);Power,2(0.06) 1.976374800759039 71.86698889732361 1.5074360370635986 5.973292827606201 0.9643884946314908 1.7041311264038086 32.5745682321172 52.60992806200045 21.717119776075343 34.72961604745407 53.37494331568847 89.37268962548806 CONFLICT 0.5588235294117647 0.4411764705882353 0.0 GO:0006695 7 cholesterol biosynthetic process 21 21 10 10 6 6 3 3 159 18 2367 0.95967 0.14515 0.14515 14.29 293688;29540;25675 tm7sf2;hsd17b7;hmgcr TM7SF2_10031;HSD17B7_8834;HMGCR_8810 28.306028 1.63089 0.977494 46.769692897173194 41.528996639931115 49.69532489198035 17.385139666666667 0.663137 0.322682 29.25869609898374 25.665072050682742 31.079668937075077 74.32177333333334 7.6286 5.49472 117.36880862393609 107.44860721860009 124.77761039357274 0.5 1.304192 1.5 41.970295 82.3097;0.977494;1.63089 51.1696;0.322682;0.663137 209.842;5.49472;7.6286 0 3 0 3 293688;29540;25675 TM7SF2_10031;HSD17B7_8834;HMGCR_8810 28.306028 1.63089 46.769692897173194 17.385139666666667 0.663137 29.25869609898374 74.32177333333334 7.6286 117.36880862393609 82.3097;0.977494;1.63089 51.1696;0.322682;0.663137 209.842;5.49472;7.6286 0 Exp 4,2(0.67);Linear,1(0.34) 1.7744108456062408 5.329771518707275 1.703133225440979 1.9017701148986816 0.10895206681579157 1.7248681783676147 -24.61886177683418 81.23091777683418 -15.72419182834934 50.494471161682675 -58.49353664351722 207.1370833101839 DOWN 0.0 1.0 0.0 GO:0007044 7 cell-substrate junction assembly 11 11 2 2 2 2 2 2 160 9 2376 0.97146 0.15174 0.15174 18.18 307582;25661 lama3;fn1 LAMA3_8980;FN1_8655 31.023465 31.023465 2.46923 40.38178640018852 48.208500481373974 32.249616802037906 15.9607005 15.9607005 0.871501 21.339350578253327 25.041960382922113 17.041987002085744 57.83025 57.83025 10.4175 67.05175407940494 86.36506422351232 53.548729953046326 0.0 2.46923 0.5 31.023465 2.46923;59.5777 0.871501;31.0499 10.4175;105.243 0 2 0 2 307582;25661 LAMA3_8980;FN1_8655 31.023465 31.023465 40.38178640018852 15.9607005 15.9607005 21.339350578253327 57.83025 57.83025 67.05175407940494 2.46923;59.5777 0.871501;31.0499 10.4175;105.243 0 Exp 4,1(0.5);Power,1(0.5) 1.7341541613602807 3.4694504737854004 1.6902168989181519 1.7792335748672485 0.06294429520229171 1.7347252368927002 -24.942835599999984 86.98976559999998 -13.61413052 45.535531520000006 -35.09873999999999 150.75923999999998 DOWN 0.0 1.0 0.0 GO:0051171 5 regulation of nitrogen compound metabolic process 917 985 79 79 65 67 56 56 106 929 1456 0.15252 0.8839 0.27955 5.69 79426;24522;246273;24825;293615;79224;24794;24648;25106;252922;192280;83516;29441;303612;363465;25513;81819;25591;81525;25493;299282;288001;58954;24516;54404;50693;306251;494344;63868;24471;25675;290556;29455;299626;25112;294515;314322;25661;361969;83928;24360;24890;29496;116636;24330;116663;140942;25423;113936;25695;114851;29184;79431;25698;25377;25373 zfp36;zfp354a;trib3;tf;sirt3;serpind1;serpina3c;serpina1;rgn;pzp;ppp1r3b;ppargc1a;por;polg2;pir;pik3r1;pax8;parp1;nfkbib;nfkbia;loc299282;kng1;klf6;jun;itih4;itih3;itih1;ier2;hspd1;hspb1;hmgcr;gnl3;gdf15;gadd45b;gadd45a;foxo3;fos;fn1;fga;fetub;fabp1;esr1;erbb3;eif4ebp1;egr1;dusp6;ddit4;ctsc;cpb2;cebpd;cdkn1a;cd36;bhlhe40;ass1;ambp;ahsg ZFP36_10204;ZFP354A_10203;TRIB3_10079;TF_10003;SIRT3_9828;SERPIND1_9812;SERPINA3C_32925;SERPINA1_9807;RGN_9699;PZP_9633;PPP1R3B_9545;PPARGC1A_33189;POR_9531;POLG2_9521;PIR_9487;PIK3R1_32562;PAX8_9432;PARP1_9425;NFKBIB_9308;NFKBIA_9307;LOC299282_9119;KNG1L1_34113;KLF6_8969;JUN_8938;ITIH4_32725;ITIH3_32422;ITIH1_33132;IER2_32643;HSPD1_8849;HSPB1_8847;HMGCR_8810;GNL3_8735;GDF15_33113;GADD45B_8679;GADD45A_8678;FOXO3_8662;FOS_8657;FN1_8655;FGA_8632;FETUB_33027;FABP1_33091;ESR1_33192;ERBB3_8571;EIF4EBP1_8550;EGR1_8533;DUSP6_8506;DDIT4_8450;CTSC_32456;CPB2_8369;CEBPD_8283;CDKN1A_8271;CD36_8243;BHLHE40_8141;ASS1_33159;AMBP_33085;AHSG_8003 40.90212687500003 33.181650000000005 1.28141E-12 31.409484287449608 44.030455519927266 30.358993775329466 27.873603467857162 24.095399999999998 1.28141E-12 21.63231743719761 30.290231366996647 21.927628562240173 66.6934985714286 49.27705 1.28142E-12 52.92166460832952 68.27219512979516 43.275934371983276 48.5 87.5889 0.348134;0.834827;108.064;45.1539;2.38018;28.261;29.766;15.797;77.4407;34.1871;36.1411;42.4094;12.4414;63.7758;50.0307;18.7324;56.8931;26.9741;30.5572;0.520151;45.2017;24.3655;18.9476;16.4324;57.1163;27.1247;98.1741;49.6814;42.2579;89.1011;1.63089;87.6357;105.149;106.367;102.919;13.1992;1.28141E-12;59.5777;28.5803;32.5155;33.8478;23.3972;60.9984;83.9001;0.750017;62.3934;87.5421;56.2386;25.8316;0.306936;6.24967;48.1296;57.8085;26.8037;17.2343;12.402 0.118102;0.27095;83.8836;28.132;0.56209;22.307;23.347;13.013;58.7732;26.3085;27.0588;26.2988;8.48981;40.9553;38.7717;11.6701;45.1162;21.799;24.2439;0.160202;30.7472;19.538;11.6941;10.5224;39.6402;21.5108;42.9071;33.4626;23.9469;60.3265;0.663137;54.41;85.3487;52.7132;89.5012;5.6804;1.28141E-12;31.0499;22.529;19.6094;26.4736;18.3088;41.6036;42.4185;0.186019;39.0875;53.2453;38.2681;20.4374;0.0732342;2.44025;37.5433;38.3491;20.9825;14.1233;10.3013 1.15962;2.99857;143.428;61.5341;8.82917;38.3264;40.8256;19.9134;89.8047;48.5666;53.6244;81.7305;79.2355;132.567;73.0083;41.5978;81.5688;35.2797;41.2611;2.88499;78.6415;32.1467;45.5481;39.929;101.869;36.4819;104.278;89.4404;102.383;106.138;7.6286;238.963;125.652;109.434;115.437;32.7581;1.28142E-12;105.243;38.8511;49.9875;46.9257;31.9156;113.972;107.32;4.70178;133.304;245.492;102.888;34.8042;1.73689;19.0606;69.1421;110.58;36.7081;21.9073;15.4235 14 42 14 24825;293615;25106;363465;81819;25591;81525;63868;290556;299626;24360;29496;116636;29184 TF_10003;SIRT3_9828;RGN_9699;PIR_9487;PAX8_9432;PARP1_9425;NFKBIB_9308;HSPD1_8849;GNL3_8735;GADD45B_8679;FABP1_33091;ERBB3_8571;EIF4EBP1_8550;CD36_8243 53.75474142857143 49.08015 27.72208140428628 35.46479928571428 38.1575 15.670376272037576 84.24469071428571 77.28855 54.45604760982066 45.1539;2.38018;77.4407;50.0307;56.8931;26.9741;30.5572;42.2579;87.6357;106.367;33.8478;60.9984;83.9001;48.1296 28.132;0.56209;58.7732;38.7717;45.1162;21.799;24.2439;23.9469;54.41;52.7132;26.4736;41.6036;42.4185;37.5433 61.5341;8.82917;89.8047;73.0083;81.5688;35.2797;41.2611;102.383;238.963;109.434;46.9257;113.972;107.32;69.1421 42 79426;24522;246273;79224;24794;24648;252922;192280;83516;29441;303612;25513;25493;299282;288001;58954;24516;54404;50693;306251;494344;24471;25675;29455;25112;294515;314322;25661;361969;83928;24890;24330;116663;140942;25423;113936;25695;114851;79431;25698;25377;25373 ZFP36_10204;ZFP354A_10203;TRIB3_10079;SERPIND1_9812;SERPINA3C_32925;SERPINA1_9807;PZP_9633;PPP1R3B_9545;PPARGC1A_33189;POR_9531;POLG2_9521;PIK3R1_32562;NFKBIA_9307;LOC299282_9119;KNG1L1_34113;KLF6_8969;JUN_8938;ITIH4_32725;ITIH3_32422;ITIH1_33132;IER2_32643;HSPB1_8847;HMGCR_8810;GDF15_33113;GADD45A_8678;FOXO3_8662;FOS_8657;FN1_8655;FGA_8632;FETUB_33027;ESR1_33192;EGR1_8533;DUSP6_8506;DDIT4_8450;CTSC_32456;CPB2_8369;CEBPD_8283;CDKN1A_8271;BHLHE40_8141;ASS1_33159;AMBP_33085;AHSG_8003 36.61792202380956 27.69285 31.69455721044329 25.343204861904795 21.246650000000002 22.883407876358664 60.84310119047621 41.2117 51.73513371366431 0.348134;0.834827;108.064;28.261;29.766;15.797;34.1871;36.1411;42.4094;12.4414;63.7758;18.7324;0.520151;45.2017;24.3655;18.9476;16.4324;57.1163;27.1247;98.1741;49.6814;89.1011;1.63089;105.149;102.919;13.1992;1.28141E-12;59.5777;28.5803;32.5155;23.3972;0.750017;62.3934;87.5421;56.2386;25.8316;0.306936;6.24967;57.8085;26.8037;17.2343;12.402 0.118102;0.27095;83.8836;22.307;23.347;13.013;26.3085;27.0588;26.2988;8.48981;40.9553;11.6701;0.160202;30.7472;19.538;11.6941;10.5224;39.6402;21.5108;42.9071;33.4626;60.3265;0.663137;85.3487;89.5012;5.6804;1.28141E-12;31.0499;22.529;19.6094;18.3088;0.186019;39.0875;53.2453;38.2681;20.4374;0.0732342;2.44025;38.3491;20.9825;14.1233;10.3013 1.15962;2.99857;143.428;38.3264;40.8256;19.9134;48.5666;53.6244;81.7305;79.2355;132.567;41.5978;2.88499;78.6415;32.1467;45.5481;39.929;101.869;36.4819;104.278;89.4404;106.138;7.6286;125.652;115.437;32.7581;1.28142E-12;105.243;38.8511;49.9875;31.9156;4.70178;133.304;245.492;102.888;34.8042;1.73689;19.0606;110.58;36.7081;21.9073;15.4235 0 Exp 2,21(0.38);Exp 3,3(0.06);Exp 4,4(0.08);Hill,6(0.11);Linear,9(0.17);Poly 2,11(0.2);Power,2(0.04) 1.854798720707463 107.32978665828705 1.5197933912277222 4.591650485992432 0.6013469085073255 1.7118040919303894 32.675479852077316 49.12877389792274 22.20775304462212 33.5394538910922 52.83246696027956 80.55453018257765 DOWN 0.25 0.75 0.0 GO:0110076 8 negative regulation of ferroptosis 1 1 1 1 1 1 1 1 161 0 2385 1.0 0.063604 0.063604 100.0 29328 gpx4 GPX4_32827 45.9204 45.9204 45.9204 45.9204 34.2198 34.2198 34.2198 34.2198 70.4292 70.4292 70.4292 70.4292 0.0 45.9204 0.0 45.9204 45.9204 34.2198 70.4292 1 0 1 29328 GPX4_32827 45.9204 45.9204 34.2198 34.2198 70.4292 70.4292 45.9204 34.2198 70.4292 0 0 Exp 2,1(1) 1.547789216041565 1.547789216041565 1.547789216041565 1.547789216041565 0.0 1.547789216041565 45.9204 45.9204 34.2198 34.2198 70.4292 70.4292 UP 1.0 0.0 0.0 GO:0030728 4 ovulation 14 18 3 3 3 2 2 2 160 16 2369 0.89794 0.31912 0.31912 11.11 294515;25146 foxo3;cyp17a1 FOXO3_8662;CYP17A1_32365 31.4457 31.4457 13.1992 25.80444776584068 35.52101960352423 25.152595586902393 20.6729 20.6729 5.6804 21.20259683387863 24.021445154185017 20.666993085612823 57.1995 57.1995 32.7581 34.56535936338576 62.65843823788547 33.69219575138881 0.0 13.1992 0.5 31.4457 13.1992;49.6922 5.6804;35.6654 32.7581;81.6409 1 1 1 25146 CYP17A1_32365 49.6922 49.6922 35.6654 35.6654 81.6409 81.6409 49.6922 35.6654 81.6409 1 294515 FOXO3_8662 13.1992 13.1992 5.6804 5.6804 32.7581 32.7581 13.1992 5.6804 32.7581 0 Exp 4,1(0.5);Linear,1(0.5) 1.948473592402838 3.8977465629577637 1.90940523147583 1.9883413314819336 0.05581625159473527 1.9488732814788818 -4.317439999999998 67.20884000000001 -8.712399999999999 50.0582 9.294356000000008 105.104644 CONFLICT 0.5 0.5 0.0 GO:0009628 3 response to abiotic stimulus 422 443 52 52 42 49 39 39 123 404 1981 0.99043 0.015988 0.024317 8.8 24522;24825;29482;24648;83516;24651;25513;25591;24314;25493;24539;24516;81678;192235;63868;24471;24464;25675;25112;294515;314322;25256;361969;24360;116636;24330;140942;25146;113936;114851;29184;246142;79431;155423;192272;24158;25287;170465;25303 zfp354a;tf;slc1a2;serpina1;ppargc1a;pklr;pik3r1;parp1;nqo1;nfkbia;lpl;jun;itpr2;hyou1;hspd1;hspb1;hp;hmgcr;gadd45a;foxo3;fos;fmo1;fga;fabp1;eif4ebp1;egr1;ddit4;cyp17a1;cpb2;cdkn1a;cd36;bmf;bhlhe40;anxa7;acot2;acadm;acadl;acaa2;abcc2 ZFP354A_10203;TF_10003;SLC1A2_33059;SERPINA1_9807;PPARGC1A_33189;PKLR_9489;PIK3R1_32562;PARP1_9425;NQO1_33055;NFKBIA_9307;LPL_32544;JUN_8938;ITPR2_8931;HYOU1_8857;HSPD1_8849;HSPB1_8847;HP_8823;HMGCR_8810;GADD45A_8678;FOXO3_8662;FOS_8657;FMO1_32787;FGA_8632;FABP1_33091;EIF4EBP1_8550;EGR1_8533;DDIT4_8450;CYP17A1_32365;CPB2_8369;CDKN1A_8271;CD36_8243;BMF_8152;BHLHE40_8141;ANXA7_8051;ACOT2_7969;ACADM_7957;ACADL_32776;ACAA2_7955;ABCC2_32541 40.11532320512824 33.4878 1.28141E-12 31.51287400376918 44.36641608447746 32.21529054938067 27.06920635897439 24.7342 1.28141E-12 21.37226587405435 30.514851083353914 23.039371028716467 65.51384461538466 45.3228 1.28142E-12 55.1092923180244 67.37460528771304 47.99442831573189 21.5 41.228049999999996 0.834827;45.1539;13.3235;15.797;42.4094;23.0963;18.7324;26.9741;87.2765;0.520151;74.2041;16.4324;31.8111;40.1982;42.2579;89.1011;64.9285;1.63089;102.919;13.1992;1.28141E-12;65.2792;28.5803;33.8478;83.9001;0.750017;87.5421;49.6922;25.8316;6.24967;48.1296;94.8767;57.8085;104.64;8.54905;11.7137;33.4878;26.5872;46.2316 0.27095;28.132;9.10952;13.013;26.2988;17.4625;11.6701;21.799;60.6992;0.160202;49.8682;10.5224;24.7342;29.3844;23.9469;60.3265;41.6103;0.663137;89.5012;5.6804;1.28141E-12;39.7882;22.529;26.4736;42.4185;0.186019;53.2453;35.6654;20.4374;2.44025;37.5433;73.1342;38.3491;43.9254;7.19676;8.36151;26.6039;21.3695;31.1788 2.99857;61.5341;24.6773;19.9134;81.7305;32.9443;41.5978;35.2797;197.117;2.88499;155.425;39.929;44.3296;62.3571;102.383;106.138;136.455;7.6286;115.437;32.7581;1.28142E-12;82.9415;38.8511;46.9257;107.32;4.70178;245.492;81.6409;34.8042;19.0606;69.1421;109.848;110.58;108.689;10.4125;18.9642;45.3228;35.0407;81.7848 16 23 16 24825;25591;24314;24539;63868;25256;24360;116636;25146;29184;246142;155423;192272;24158;25287;170465 TF_10003;PARP1_9425;NQO1_33055;LPL_32544;HSPD1_8849;FMO1_32787;FABP1_33091;EIF4EBP1_8550;CYP17A1_32365;CD36_8243;BMF_8152;ANXA7_8051;ACOT2_7969;ACADM_7957;ACADL_32776;ACAA2_7955 52.285615625 46.64175 29.616265092657674 34.18284812500001 31.898699999999998 17.596971777815703 79.2491375 75.39150000000001 50.142013915928494 45.1539;26.9741;87.2765;74.2041;42.2579;65.2792;33.8478;83.9001;49.6922;48.1296;94.8767;104.64;8.54905;11.7137;33.4878;26.5872 28.132;21.799;60.6992;49.8682;23.9469;39.7882;26.4736;42.4185;35.6654;37.5433;73.1342;43.9254;7.19676;8.36151;26.6039;21.3695 61.5341;35.2797;197.117;155.425;102.383;82.9415;46.9257;107.32;81.6409;69.1421;109.848;108.689;10.4125;18.9642;45.3228;35.0407 23 24522;29482;24648;83516;24651;25513;25493;24516;81678;192235;24471;24464;25675;25112;294515;314322;361969;24330;140942;113936;114851;79431;25303 ZFP354A_10203;SLC1A2_33059;SERPINA1_9807;PPARGC1A_33189;PKLR_9489;PIK3R1_32562;NFKBIA_9307;JUN_8938;ITPR2_8931;HYOU1_8857;HSPB1_8847;HP_8823;HMGCR_8810;GADD45A_8678;FOXO3_8662;FOS_8657;FGA_8632;EGR1_8533;DDIT4_8450;CPB2_8369;CDKN1A_8271;BHLHE40_8141;ABCC2_32541 31.649032826087012 23.0963 30.571099942450964 22.120586000000056 17.4625 22.70331916453384 55.958858260869626 38.8511 57.43596889008869 0.834827;13.3235;15.797;42.4094;23.0963;18.7324;0.520151;16.4324;31.8111;40.1982;89.1011;64.9285;1.63089;102.919;13.1992;1.28141E-12;28.5803;0.750017;87.5421;25.8316;6.24967;57.8085;46.2316 0.27095;9.10952;13.013;26.2988;17.4625;11.6701;0.160202;10.5224;24.7342;29.3844;60.3265;41.6103;0.663137;89.5012;5.6804;1.28141E-12;22.529;0.186019;53.2453;20.4374;2.44025;38.3491;31.1788 2.99857;24.6773;19.9134;81.7305;32.9443;41.5978;2.88499;39.929;44.3296;62.3571;106.138;136.455;7.6286;115.437;32.7581;1.28142E-12;38.8511;4.70178;245.492;34.8042;19.0606;110.58;81.7848 0 Exp 2,15(0.39);Exp 3,3(0.08);Exp 4,4(0.11);Hill,3(0.08);Linear,5(0.13);Poly 2,9(0.24) 1.9890193624637122 86.66388177871704 1.522104263305664 11.836054801940918 1.7091267474208127 1.7576230764389038 30.224970467909102 50.00567594234737 20.36149546396856 33.776917253980216 48.217728112060016 82.80996111870927 CONFLICT 0.41025641025641024 0.5897435897435898 0.0 GO:0035914 5 skeletal muscle cell differentiation 14 15 3 3 3 2 2 2 160 13 2372 0.93468 0.24652 0.24652 13.33 314322;24330 fos;egr1 FOS_8657;EGR1_8533 0.37500850000064073 0.37500850000064073 1.28141E-12 0.5303421067042847 0.5422646050740609 0.4746720349619059 0.0930095000006407 0.0930095000006407 1.28141E-12 0.13153529632863428 0.134492310936248 0.11772802119301481 2.350890000000641 2.350890000000641 1.28142E-12 3.3246605216463796 3.3994014466921616 2.97567052552995 0.0 1.28141E-12 0.5 0.37500850000064073 1.28141E-12;0.750017 1.28141E-12;0.186019 1.28142E-12;4.70178 0 2 0 2 314322;24330 FOS_8657;EGR1_8533 0.37500850000064073 0.37500850000064073 0.5303421067042847 0.0930095000006407 0.0930095000006407 0.13153529632863428 2.350890000000641 2.350890000000641 3.3246605216463796 1.28141E-12;0.750017 1.28141E-12;0.186019 1.28142E-12;4.70178 0 Hill,2(1) 2.8285487556853006 6.1149537563323975 1.8966681957244873 4.21828556060791 1.6416313820295116 3.0574768781661987 -0.3600081599981035 1.110025159999385 -0.0892891199981035 0.27530811999938487 -2.256854399998103 6.958634399999385 DOWN 0.0 1.0 0.0 GO:0043502 5 regulation of muscle adaptation 33 33 2 2 2 2 2 2 160 31 2354 0.64906 0.63119 1.0 6.06 25591;294515 parp1;foxo3 PARP1_9425;FOXO3_8662 20.08665 20.08665 13.1992 9.740325200166575 24.416153012428904 7.575271766460782 13.7397 13.7397 5.6804 11.397571363233487 18.805836760058984 8.864149684925122 34.0189 34.0189 32.7581 1.783040459439888 34.811448388455865 1.3867109950932692 0.5 20.08665 26.9741;13.1992 21.799;5.6804 35.2797;32.7581 1 1 1 25591 PARP1_9425 26.9741 26.9741 21.799 21.799 35.2797 35.2797 26.9741 21.799 35.2797 1 294515 FOXO3_8662 13.1992 13.1992 5.6804 5.6804 32.7581 32.7581 13.1992 5.6804 32.7581 0 Exp 2,1(0.5);Exp 4,1(0.5) 1.8963788367052183 3.7970110177993774 1.8086696863174438 1.9883413314819336 0.12704703868275385 1.8985055088996887 6.587247999999999 33.586051999999995 -2.0565279999999984 29.535928 31.547732000000003 36.490068 CONFLICT 0.5 0.5 0.0 GO:0045893 8 positive regulation of transcription, DNA-templated 299 321 23 23 18 19 16 16 146 305 2080 0.16933 0.8883 0.32799 4.98 24825;293615;83516;25513;81819;25591;25493;58954;24516;494344;290556;294515;314322;24890;24330;25695 tf;sirt3;ppargc1a;pik3r1;pax8;parp1;nfkbia;klf6;jun;ier2;gnl3;foxo3;fos;esr1;egr1;cebpd TF_10003;SIRT3_9828;PPARGC1A_33189;PIK3R1_32562;PAX8_9432;PARP1_9425;NFKBIA_9307;KLF6_8969;JUN_8938;IER2_32643;GNL3_8735;FOXO3_8662;FOS_8657;ESR1_33192;EGR1_8533;CEBPD_8283 25.21335525000008 18.84 1.28141E-12 25.148733842084745 27.418744422872646 22.654775211010275 16.75474657500008 11.6821 1.28141E-12 16.997800193565606 18.912517123608527 16.304360143076973 49.90112062500008 37.60435 1.28142E-12 58.43961472397901 47.498320547495965 41.41304420967297 45.1539;2.38018;42.4094;18.7324;56.8931;26.9741;0.520151;18.9476;16.4324;49.6814;87.6357;13.1992;1.28141E-12;23.3972;0.750017;0.306936 28.132;0.56209;26.2988;11.6701;45.1162;21.799;0.160202;11.6941;10.5224;33.4626;54.41;5.6804;1.28141E-12;18.3088;0.186019;0.0732342 61.5341;8.82917;81.7305;41.5978;81.5688;35.2797;2.88499;45.5481;39.929;89.4404;238.963;32.7581;1.28142E-12;31.9156;4.70178;1.73689 5 11 5 24825;293615;81819;25591;290556 TF_10003;SIRT3_9828;PAX8_9432;PARP1_9425;GNL3_8735 43.807396 45.1539 31.99040103471791 30.003858 28.132 20.98620915141226 85.23495399999999 61.5341 90.19541912331013 45.1539;2.38018;56.8931;26.9741;87.6357 28.132;0.56209;45.1162;21.799;54.41 61.5341;8.82917;81.5688;35.2797;238.963 11 83516;25513;25493;58954;24516;494344;294515;314322;24890;24330;25695 PPARGC1A_33189;PIK3R1_32562;NFKBIA_9307;KLF6_8969;JUN_8938;IER2_32643;FOXO3_8662;FOS_8657;ESR1_33192;EGR1_8533;CEBPD_8283 16.76151854545466 16.4324 16.96725798974413 10.732423200000115 10.5224 11.38221128864821 33.84028727272739 32.7581 30.99535620131301 42.4094;18.7324;0.520151;18.9476;16.4324;49.6814;13.1992;1.28141E-12;23.3972;0.750017;0.306936 26.2988;11.6701;0.160202;11.6941;10.5224;33.4626;5.6804;1.28141E-12;18.3088;0.186019;0.0732342 81.7305;41.5978;2.88499;45.5481;39.929;89.4404;32.7581;1.28142E-12;31.9156;4.70178;1.73689 0 Exp 2,6(0.38);Exp 4,2(0.13);Hill,4(0.25);Poly 2,4(0.25) 1.889851980238015 31.269975900650024 1.5209722518920898 4.21828556060791 0.6419074908207971 1.7867289185523987 12.890475667378555 37.53623483262161 8.42582448015293 25.083668669847224 21.26570941025037 78.5365318397498 DOWN 0.3125 0.6875 0.0 GO:0051603 6 proteolysis involved in cellular protein catabolic process 79 84 4 4 4 4 4 4 158 80 2305 0.37175 0.79384 0.81847 4.76 312688;29676;85253;25423 usp18;psmb3;plg;ctsc USP18_10138;PSMB3_9589;PLG_9501;CTSC_32456 64.924025 63.512150000000005 23.7888 35.28122286281803 63.236283354899925 28.884018921834368 44.229375 42.25185 19.2724 22.34813585907858 42.78575084972394 18.1694795486091 105.628 120.516 30.901 53.75721590633205 111.4326702035887 49.12479881852983 108.883;23.7888;70.7857;56.2386 73.1414;19.2724;46.2356;38.2681 138.144;30.901;150.579;102.888 2 2 2 312688;29676 USP18_10138;PSMB3_9589 66.3359 66.3359 60.17068585964431 46.206900000000005 46.206900000000005 38.09113519573812 84.52250000000001 84.52250000000001 75.83225253478892 108.883;23.7888 73.1414;19.2724 138.144;30.901 2 85253;25423 PLG_9501;CTSC_32456 63.512150000000005 63.512150000000005 10.28635305659875 42.25185 42.25185 5.633873279103845 126.7335 126.7335 33.72262950156764 70.7857;56.2386 46.2356;38.2681 150.579;102.888 0 Exp 2,2(0.5);Linear,1(0.25);Power,1(0.25) 1.606700899196022 6.4323214292526245 1.5254690647125244 1.705338716506958 0.07716129982352633 1.600756824016571 30.348426594438337 99.49962340556166 22.328201858103007 66.13054814189701 52.945928411794604 158.31007158820543 CONFLICT 0.5 0.5 0.0 GO:0016042 5 lipid catabolic process 77 87 35 35 22 30 19 19 143 68 2317 1.0 1.046E-6 1.046E-6 21.84 360268;65192;24539;289456;171155;113965;85255;295143;171142;291075;29740;25428;83842;497840;50681;192272;24158;25287;170465 sult1e1;slc27a2;lpl;hsd17b11;hadhb;hadh;hacl1;etfdh;ehhadh;eci2;eci1;cyp7a1;crot;cps1;acox1;acot2;acadm;acadl;acaa2 SULT1E1_32446;SLC27A2_9860;LPL_32544;HSD17B11_8832;HADHB_8777;HADH_8776;HACL1_8775;ETFDH_8575;EHHADH_8534;ECI2_8521;ECI1_8520;CYP7A1_8430;CROT_8384;CPS1_32421;ACOX1_7973;ACOT2_7969;ACADM_7957;ACADL_32776;ACAA2_7955 22.904589999999995 18.1231 5.72128 17.31456901763689 25.894750042441256 19.963342647194697 16.936799105263155 14.869 0.985273 12.381625401531759 19.12693595138045 13.582923385650899 36.4594947368421 29.2247 10.316 33.84305813884756 42.39986281858574 42.01353776178563 3.5 8.58857 7.5 14.787400000000002 50.1846;7.62189;74.2041;22.4334;31.8029;33.3125;17.6275;18.1231;8.62809;10.6467;11.9473;5.72128;7.4229;31.9826;23.1906;8.54905;11.7137;33.4878;26.5872 36.5009;5.49916;49.8682;18.1233;25.5756;25.7336;11.195;14.869;7.31865;8.92359;7.15307;0.985273;5.75707;24.4836;16.2815;7.19676;8.36151;26.6039;21.3695 80.9788;13.3925;155.425;29.2247;42.1484;46.9856;37.6534;23.0103;10.3909;13.0581;19.001;22.3625;10.316;45.5891;33.4539;10.4125;18.9642;45.3228;35.0407 17 2 17 360268;65192;24539;289456;171155;113965;85255;295143;171142;291075;29740;83842;50681;192272;24158;25287;170465 SULT1E1_32446;SLC27A2_9860;LPL_32544;HSD17B11_8832;HADHB_8777;HADH_8776;HACL1_8775;ETFDH_8575;EHHADH_8534;ECI2_8521;ECI1_8520;CROT_8384;ACOX1_7973;ACOT2_7969;ACADM_7957;ACADL_32776;ACAA2_7955 23.381372352941174 18.1231 17.70373642179051 17.43119470588235 14.869 12.359012421380056 36.75169411764706 29.2247 35.64829948118969 50.1846;7.62189;74.2041;22.4334;31.8029;33.3125;17.6275;18.1231;8.62809;10.6467;11.9473;7.4229;23.1906;8.54905;11.7137;33.4878;26.5872 36.5009;5.49916;49.8682;18.1233;25.5756;25.7336;11.195;14.869;7.31865;8.92359;7.15307;5.75707;16.2815;7.19676;8.36151;26.6039;21.3695 80.9788;13.3925;155.425;29.2247;42.1484;46.9856;37.6534;23.0103;10.3909;13.0581;19.001;10.316;33.4539;10.4125;18.9642;45.3228;35.0407 2 25428;497840 CYP7A1_8430;CPS1_32421 18.85194 18.85194 18.569557454909905 12.7344365 12.7344365 16.61582636823894 33.9758 33.9758 16.423686363907468 5.72128;31.9826 0.985273;24.4836 22.3625;45.5891 0 Exp 2,7(0.37);Hill,3(0.16);Linear,5(0.27);Poly 2,3(0.16);Power,1(0.06) 3.2437344346264494 99.57295405864716 1.559399127960205 32.73371124267578 7.43099129043446 2.18471097946167 15.119010266646034 30.69016973335397 11.36934133637768 22.504256874148638 21.24179989892042 51.67718957476379 UP 0.8947368421052632 0.10526315789473684 0.0 GO:0009719 3 response to endogenous stimulus 481 515 74 73 55 67 50 50 112 465 1920 0.99969 6.0006E-4 8.1717E-4 9.71 79426;286954;246273;24825;170698;25351;24648;83516;29441;24651;25513;81819;25591;24314;24552;58954;24516;81678;494344;63868;24471;29540;24464;113965;81869;29328;24384;294515;314322;25661;361969;24890;29496;25315;116636;24330;140942;25146;497840;81718;114851;29184;25698;65054;25373;192272;24158;312382;140668;25303 zfp36;ugt2b1;trib3;tf;slco1a2;slc2a2;serpina1;ppargc1a;por;pklr;pik3r1;pax8;parp1;nqo1;me1;klf6;jun;itpr2;ier2;hspd1;hspb1;hsd17b7;hp;hadh;gstm7;gpx4;gc;foxo3;fos;fn1;fga;esr1;erbb3;ephx1;eif4ebp1;egr1;ddit4;cyp17a1;cps1;cdo1;cdkn1a;cd36;ass1;aqp9;ahsg;acot2;acadm;abcg2;abcc3;abcc2 ZFP36_10204;UGT2B10_33303,UGT2B1_33224;TRIB3_10079;TF_10003;SLCO1A2_9886;SLC2A2_9863;SERPINA1_9807;PPARGC1A_33189;POR_9531;PKLR_9489;PIK3R1_32562;PAX8_9432;PARP1_9425;NQO1_33055;ME1_9215;KLF6_8969;JUN_8938;ITPR2_8931;IER2_32643;HSPD1_8849;HSPB1_8847;HSD17B7_8834;HP_8823;HADH_8776;GSTM7_8761;GPX4_32827;GC_32893;FOXO3_8662;FOS_8657;FN1_8655;FGA_8632;ESR1_33192;ERBB3_8571;EPHX1_8567;EIF4EBP1_8550;EGR1_8533;DDIT4_8450;CYP17A1_32365;CPS1_32421;CDO1_8275;CDKN1A_8271;CD36_8243;ASS1_33159;AQP9_32709;AHSG_8003;ACOT2_7969;ACADM_7957;ABCG2_32656;ABCC3_7941;ABCC2_32541 37.66502910000003 31.89685 1.28141E-12 27.962108020569318 37.58083550341152 24.638630318961287 26.272630260000025 24.215249999999997 1.28141E-12 19.73287762847296 25.82506727688193 16.870324642732882 63.12436540000003 46.28735 1.28142E-12 49.48035897010615 62.23475585869831 40.53988227784905 24.5 31.89685 0.348134;47.47345;108.064;45.1539;104.197;29.7555;15.797;42.4094;12.4414;23.0963;18.7324;56.8931;26.9741;87.2765;80.7944;18.9476;16.4324;31.8111;49.6814;42.2579;89.1011;0.977494;64.9285;33.3125;42.3152;45.9204;42.356;13.1992;1.28141E-12;59.5777;28.5803;23.3972;60.9984;12.4747;83.9001;0.750017;87.5421;49.6922;31.9826;22.9638;6.24967;48.1296;26.8037;27.7316;12.402;8.54905;11.7137;5.21654;37.7175;46.2316 0.118102;34.82915;83.8836;28.132;80.3101;23.3399;13.013;26.2988;8.48981;17.4625;11.6701;45.1162;21.799;60.6992;59.856;11.6941;10.5224;24.7342;33.4626;23.9469;60.3265;0.322682;41.6103;25.7336;31.4035;34.2198;26.3722;5.6804;1.28141E-12;31.0499;22.529;18.3088;41.6036;7.00435;42.4185;0.186019;53.2453;35.6654;24.4836;18.5144;2.44025;37.5433;20.9825;21.9372;10.3013;7.19676;8.36151;2.73368;30.9007;31.1788 1.15962;76.47475;143.428;61.5341;128.412;40.808;19.9134;81.7305;79.2355;32.9443;41.5978;81.5688;35.2797;197.117;94.0621;45.5481;39.929;44.3296;89.4404;102.383;106.138;5.49472;136.455;46.9856;64.5991;70.4292;78.7583;32.7581;1.28142E-12;105.243;38.8511;31.9156;113.972;23.684;107.32;4.70178;245.492;81.6409;45.5891;30.0179;19.0606;69.1421;36.7081;37.4625;15.4235;10.4125;18.9642;11.386;48.9329;81.7848 19 32 18 286954;24825;81819;25591;24314;63868;113965;81869;29328;29496;25315;116636;25146;29184;192272;24158;312382;140668 UGT2B10_33303,UGT2B1_33224;TF_10003;PAX8_9432;PARP1_9425;NQO1_33055;HSPD1_8849;HADH_8776;GSTM7_8761;GPX4_32827;ERBB3_8571;EPHX1_8567;EIF4EBP1_8550;CYP17A1_32365;CD36_8243;ACOT2_7969;ACADM_7957;ABCG2_32656;ABCC3_7941 41.44271333333333 43.73455 23.15611815227673 28.850397222222213 31.1521 15.252720586283399 67.87921388888888 66.8706 45.231991703627216 47.47345;45.1539;56.8931;26.9741;87.2765;42.2579;33.3125;42.3152;45.9204;60.9984;12.4747;83.9001;49.6922;48.1296;8.54905;11.7137;5.21654;37.7175 34.82915;28.132;45.1162;21.799;60.6992;23.9469;25.7336;31.4035;34.2198;41.6036;7.00435;42.4185;35.6654;37.5433;7.19676;8.36151;2.73368;30.9007 76.47475;61.5341;81.5688;35.2797;197.117;102.383;46.9856;64.5991;70.4292;113.972;23.684;107.32;81.6409;69.1421;10.4125;18.9642;11.386;48.9329 32 79426;246273;170698;25351;24648;83516;29441;24651;25513;24552;58954;24516;81678;494344;24471;29540;24464;24384;294515;314322;25661;361969;24890;24330;140942;497840;81718;114851;25698;65054;25373;25303 ZFP36_10204;TRIB3_10079;SLCO1A2_9886;SLC2A2_9863;SERPINA1_9807;PPARGC1A_33189;POR_9531;PKLR_9489;PIK3R1_32562;ME1_9215;KLF6_8969;JUN_8938;ITPR2_8931;IER2_32643;HSPB1_8847;HSD17B7_8834;HP_8823;GC_32893;FOXO3_8662;FOS_8657;FN1_8655;FGA_8632;ESR1_33192;EGR1_8533;DDIT4_8450;CPS1_32421;CDO1_8275;CDKN1A_8271;ASS1_33159;AQP9_32709;AHSG_8003;ABCC2_32541 35.54008171875004 27.26765 30.47750466978905 24.822636343750045 21.459850000000003 21.951615375244323 60.449763125000025 41.2029 52.224781408559224 0.348134;108.064;104.197;29.7555;15.797;42.4094;12.4414;23.0963;18.7324;80.7944;18.9476;16.4324;31.8111;49.6814;89.1011;0.977494;64.9285;42.356;13.1992;1.28141E-12;59.5777;28.5803;23.3972;0.750017;87.5421;31.9826;22.9638;6.24967;26.8037;27.7316;12.402;46.2316 0.118102;83.8836;80.3101;23.3399;13.013;26.2988;8.48981;17.4625;11.6701;59.856;11.6941;10.5224;24.7342;33.4626;60.3265;0.322682;41.6103;26.3722;5.6804;1.28141E-12;31.0499;22.529;18.3088;0.186019;53.2453;24.4836;18.5144;2.44025;20.9825;21.9372;10.3013;31.1788 1.15962;143.428;128.412;40.808;19.9134;81.7305;79.2355;32.9443;41.5978;94.0621;45.5481;39.929;44.3296;89.4404;106.138;5.49472;136.455;78.7583;32.7581;1.28142E-12;105.243;38.8511;31.9156;4.70178;245.492;45.5891;30.0179;19.0606;36.7081;37.4625;15.4235;81.7848 0 Exp 2,18(0.36);Exp 3,3(0.06);Exp 4,4(0.08);Hill,4(0.08);Linear,11(0.22);Poly 2,10(0.2);Power,1(0.02) 1.965136479357638 109.07431602478027 1.5074360370635986 11.836054801940918 1.4750324294147128 1.7792335748672485 29.914328190534825 45.41573000946523 20.802955639300347 31.742304880699702 49.409109633583824 76.83962116641626 DOWN 0.36 0.64 0.0 GO:0010001 5 glial cell differentiation 30 32 3 3 2 3 2 2 160 30 2355 0.66694 0.6142 1.0 6.25 29496;24330 erbb3;egr1 ERBB3_8571;EGR1_8533 30.874208499999998 30.874208499999998 0.750017 42.60204017482431 30.47621894138842 42.59832198197268 20.8948095 20.8948095 0.186019 29.28665238544311 20.62121270021619 29.284096324252122 59.33689 59.33689 4.70178 77.2657135437459 58.615071347585875 77.25896999760126 0.5 30.874208499999998 60.9984;0.750017 41.6036;0.186019 113.972;4.70178 1 1 1 29496 ERBB3_8571 60.9984 60.9984 41.6036 41.6036 113.972 113.972 60.9984 41.6036 113.972 1 24330 EGR1_8533 0.750017 0.750017 0.186019 0.186019 4.70178 4.70178 0.750017 0.186019 4.70178 0 Hill,1(0.5);Linear,1(0.5) 2.5989905224765706 5.8195881843566895 1.6013026237487793 4.21828556060791 1.850486380902578 2.9097940921783447 -28.169206839999998 89.91762383999999 -19.69441987999999 61.48403887999999 -47.747925599999974 166.42170559999997 CONFLICT 0.5 0.5 0.0 GO:0060416 6 response to growth hormone 18 18 10 10 8 8 6 6 156 12 2373 0.99994 5.9037E-4 5.9037E-4 33.33 286954;24464;361969;497840;29184;25698 ugt2b1;hp;fga;cps1;cd36;ass1 UGT2B10_33303,UGT2B1_33224;HP_8823;FGA_8632;CPS1_32421;CD36_8243;ASS1_33159 41.31635833333334 39.728025 26.8037 14.844573097816443 42.27897786601943 14.721860776138435 30.329641666666664 29.656374999999997 20.9825 8.739919509264196 31.02721773327169 8.67026279906871 67.20335833333333 57.3656 36.7081 37.64703120548043 68.93857994749528 37.524020586451286 0.0 26.8037 0.5 27.692 47.47345;64.9285;28.5803;31.9826;48.1296;26.8037 34.82915;41.6103;22.529;24.4836;37.5433;20.9825 76.47475;136.455;38.8511;45.5891;69.1421;36.7081 3 4 2 286954;29184 UGT2B10_33303,UGT2B1_33224;CD36_8243 47.801525 47.801525 0.4639681144755675 36.186225 36.186225 1.919193870157433 72.808425 72.808425 5.184966539067634 47.47345;48.1296 34.82915;37.5433 76.47475;69.1421 4 24464;361969;497840;25698 HP_8823;FGA_8632;CPS1_32421;ASS1_33159 38.073775 30.28145 18.031632628869193 27.40135 23.5063 9.580343678769216 64.400825 42.2201 48.18492363768118 64.9285;28.5803;31.9826;26.8037 41.6103;22.529;24.4836;20.9825 136.455;38.8511;45.5891;36.7081 0 Exp 2,6(0.86);Linear,1(0.15) 1.8244679480261294 12.968739986419678 1.541895866394043 2.6703107357025146 0.37976756861401695 1.7730062007904053 29.438226017228452 53.194490649438215 23.33624955770689 37.32303377562645 37.079459517206246 97.32725714946044 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0032412 6 regulation of ion transmembrane transporter activity 53 55 6 5 5 4 4 4 158 51 2334 0.73023 0.46756 0.77666 7.27 362895;25106;83516;81869 stac3;rgn;ppargc1a;gstm7 STAC3_9953;RGN_9699;PPARGC1A_33189;GSTM7_8761 56.351150000000004 52.824349999999995 42.3152 17.16193476942501 56.31040380365188 17.107637986798046 39.794650000000004 37.0533 26.2988 14.38973948165844 39.683833265354515 14.395195448784317 89.41357500000001 85.7676 64.5991 23.845078569993547 89.73619774247095 23.757411509498557 1.5 52.824349999999995 63.2393;77.4407;42.4094;42.3152 42.7031;58.7732;26.2988;31.4035 121.52;89.8047;81.7305;64.5991 2 2 2 25106;81869 RGN_9699;GSTM7_8761 59.87795 59.87795 24.837479242568097 45.088350000000005 45.088350000000005 19.353300469041443 77.2019 77.2019 17.823050683875703 77.4407;42.3152 58.7732;31.4035 89.8047;64.5991 2 362895;83516 STAC3_9953;PPARGC1A_33189 52.824349999999995 52.824349999999995 14.728963541437698 34.50095 34.50095 11.599591770618453 101.62525 101.62525 28.135425270022225 63.2393;42.4094 42.7031;26.2988 121.52;81.7305 0 Exp 2,1(0.25);Linear,2(0.5);Poly 2,1(0.25) 1.9755657016225177 8.106813192367554 1.7198865413665771 2.879150867462158 0.5685325484073154 1.7538878917694092 39.532453925963466 73.16984607403654 25.69270530797472 53.89659469202529 66.04539800140631 112.7817519985937 CONFLICT 0.5 0.5 0.0 GO:0032482 8 Rab protein signal transduction 6 7 1 1 1 1 1 1 161 6 2379 0.93166 0.36908 0.36908 14.29 308821 rab30 RAB30_9639 26.4203 26.4203 26.4203 26.4203 21.0125 21.0125 21.0125 21.0125 35.3561 35.3561 35.3561 35.3561 0.0 26.4203 0.0 26.4203 26.4203 21.0125 35.3561 1 0 1 308821 RAB30_9639 26.4203 26.4203 21.0125 21.0125 35.3561 35.3561 26.4203 21.0125 35.3561 0 0 Linear,1(1) 2.945132255554199 2.945132255554199 2.945132255554199 2.945132255554199 0.0 2.945132255554199 26.4203 26.4203 21.0125 21.0125 35.3561 35.3561 UP 1.0 0.0 0.0 GO:0046685 4 response to arsenic-containing substance 19 20 4 4 4 2 2 2 160 18 2367 0.86982 0.36669 0.36669 10.0 114851;25303 cdkn1a;abcc2 CDKN1A_8271;ABCC2_32541 26.240635 26.240635 6.24967 28.271493827925852 18.06322475168416 25.798009351962186 16.809525 16.809525 2.44025 20.32122358646865 10.931696858843804 18.543311482508038 50.422700000000006 50.422700000000006 19.0606 44.35270716450123 37.59386667711107 40.47227080319401 0.0 6.24967 1.0 46.2316 6.24967;46.2316 2.44025;31.1788 19.0606;81.7848 0 2 0 2 114851;25303 CDKN1A_8271;ABCC2_32541 26.240635 26.240635 28.271493827925852 16.809525 16.809525 20.32122358646865 50.422700000000006 50.422700000000006 44.35270716450123 6.24967;46.2316 2.44025;31.1788 19.0606;81.7848 0 Exp 2,1(0.5);Exp 4,1(0.5) 1.682123730474141 3.381070375442505 1.522104263305664 1.8589661121368408 0.23819729763156275 1.6905351877212524 -12.9416564 65.4229264 -11.354253999999997 44.973304 -11.047016 111.89241600000001 DOWN 0.0 1.0 0.0 GO:0008284 6 positive regulation of cell population proliferation 272 293 20 20 13 16 11 11 151 282 2103 0.028827 0.9858 0.055595 3.75 24825;83516;24516;65164;25675;24957;25661;24890;29496;24330;114851 tf;ppargc1a;jun;htra1;hmgcr;glul;fn1;esr1;erbb3;egr1;cdkn1a TF_10003;PPARGC1A_33189;JUN_8938;HTRA1_8856;HMGCR_8810;GLUL_32832;FN1_8655;ESR1_33192;ERBB3_8571;EGR1_8533;CDKN1A_8271 28.74534336363636 26.4669 0.750017 21.625161633371455 32.85481930612278 22.582405812720133 18.715000545454547 21.0456 0.186019 13.698943577705643 20.635768677689278 13.947044227511114 49.800761818181826 39.929 4.70178 37.06753697782516 56.94465378807627 38.686621937249626 45.1539;42.4094;16.4324;33.1323;1.63089;26.4669;59.5777;23.3972;60.9984;0.750017;6.24967 28.132;26.2988;10.5224;25.6145;0.663137;21.0456;31.0499;18.3088;41.6036;0.186019;2.44025 61.5341;81.7305;39.929;46.6629;7.6286;35.4303;105.243;31.9156;113.972;4.70178;19.0606 2 9 2 24825;29496 TF_10003;ERBB3_8571 53.07615 53.07615 11.20375339451025 34.8678 34.8678 9.525859713432697 87.75305 87.75305 37.07919468118202 45.1539;60.9984 28.132;41.6036 61.5341;113.972 9 83516;24516;65164;25675;24957;25661;24890;24330;114851 PPARGC1A_33189;JUN_8938;HTRA1_8856;HMGCR_8810;GLUL_32832;FN1_8655;ESR1_33192;EGR1_8533;CDKN1A_8271 23.338497444444442 23.3972 19.697302855569568 15.125489555555557 18.3088 11.979573163382366 41.36692000000001 35.4303 33.24950516740962 42.4094;16.4324;33.1323;1.63089;26.4669;59.5777;23.3972;0.750017;6.24967 26.2988;10.5224;25.6145;0.663137;21.0456;31.0499;18.3088;0.186019;2.44025 81.7305;39.929;46.6629;7.6286;35.4303;105.243;31.9156;4.70178;19.0606 0 Exp 2,2(0.19);Exp 4,2(0.19);Hill,1(0.1);Linear,3(0.28);Poly 2,2(0.19);Power,1(0.1) 1.9951000921370807 22.952858686447144 1.522104263305664 4.21828556060791 0.7672099383475602 1.8344712257385254 15.965689504489353 41.52499722278338 10.619442226533009 26.810558864376084 27.895247306016543 71.7062763303471 DOWN 0.18181818181818182 0.8181818181818182 0.0 GO:0048523 5 negative regulation of cellular process 938 999 90 90 76 79 67 67 95 932 1453 0.74576 0.30998 0.56176 6.71 257644;79426;24522;308843;246273;293615;79224;24794;24648;25106;252922;83516;29441;85253;25513;81819;25591;24314;25493;24567;24539;299282;288001;24516;81678;54404;50693;306251;192235;65164;63868;24471;24464;25675;113965;81869;29328;29455;299626;25112;294515;25661;246186;361969;83928;24360;24890;29496;116636;24330;116663;140942;25428;65210;25423;113936;25695;114851;29184;246142;79431;25698;25377;25373;50559;25287;170465 zwint;zfp36;zfp354a;tsku;trib3;sirt3;serpind1;serpina3c;serpina1;rgn;pzp;ppargc1a;por;plg;pik3r1;pax8;parp1;nqo1;nfkbia;mt1;lpl;loc299282;kng1;jun;itpr2;itih4;itih3;itih1;hyou1;htra1;hspd1;hspb1;hp;hmgcr;hadh;gstm7;gpx4;gdf15;gadd45b;gadd45a;foxo3;fn1;fgl1;fga;fetub;fabp1;esr1;erbb3;eif4ebp1;egr1;dusp6;ddit4;cyp7a1;cyp2j4;ctsc;cpb2;cebpd;cdkn1a;cd36;bmf;bhlhe40;ass1;ambp;ahsg;acot1;acadl;acaa2 ZWINT_10214;ZFP36_10204;ZFP354A_10203;TSKU_10094;TRIB3_10079;SIRT3_9828;SERPIND1_9812;SERPINA3C_32925;SERPINA1_9807;RGN_9699;PZP_9633;PPARGC1A_33189;POR_9531;PLG_9501;PIK3R1_32562;PAX8_9432;PARP1_9425;NQO1_33055;NFKBIA_9307;MT1A_9255;LPL_32544;LOC299282_9119;KNG1L1_34113;JUN_8938;ITPR2_8931;ITIH4_32725;ITIH3_32422;ITIH1_33132;HYOU1_8857;HTRA1_8856;HSPD1_8849;HSPB1_8847;HP_8823;HMGCR_8810;HADH_8776;GSTM7_8761;GPX4_32827;GDF15_33113;GADD45B_8679;GADD45A_8678;FOXO3_8662;FN1_8655;FGL1_8640;FGA_8632;FETUB_33027;FABP1_33091;ESR1_33192;ERBB3_8571;EIF4EBP1_8550;EGR1_8533;DUSP6_8506;DDIT4_8450;CYP7A1_8430;CYP2J4_32580;CTSC_32456;CPB2_8369;CEBPD_8283;CDKN1A_8271;CD36_8243;BMF_8152;BHLHE40_8141;ASS1_33159;AMBP_33085;AHSG_8003;ACOT1_7968;ACADL_32776;ACAA2_7955 40.65650962686566 33.1323 0.306936 30.697656675669272 44.39176899761911 30.325024990798397 28.26662485373134 25.6145 0.0732342 21.441446619738976 31.049559979146423 21.88849262217523 65.44976179104479 46.9257 1.15962 50.32225204658552 69.40688754529448 45.53347284774071 48.5 57.4624 52.0003;0.348134;0.834827;1.38416;108.064;2.38018;28.261;29.766;15.797;77.4407;34.1871;42.4094;12.4414;70.7857;18.7324;56.8931;26.9741;87.2765;0.520151;12.9315;74.2041;45.2017;24.3655;16.4324;31.8111;57.1163;27.1247;98.1741;40.1982;33.1323;42.2579;89.1011;64.9285;1.63089;33.3125;42.3152;45.9204;105.149;106.367;102.919;13.1992;59.5777;15.4757;28.5803;32.5155;33.8478;23.3972;60.9984;83.9001;0.750017;62.3934;87.5421;5.72128;17.8395;56.2386;25.8316;0.306936;6.24967;48.1296;94.8767;57.8085;26.8037;17.2343;12.402;31.2018;33.4878;26.5872 38.9015;0.118102;0.27095;0.540568;83.8836;0.56209;22.307;23.347;13.013;58.7732;26.3085;26.2988;8.48981;46.2356;11.6701;45.1162;21.799;60.6992;0.160202;8.91033;49.8682;30.7472;19.538;10.5224;24.7342;39.6402;21.5108;42.9071;29.3844;25.6145;23.9469;60.3265;41.6103;0.663137;25.7336;31.4035;34.2198;85.3487;52.7132;89.5012;5.6804;31.0499;10.2138;22.529;19.6094;26.4736;18.3088;41.6036;42.4185;0.186019;39.0875;53.2453;0.985273;14.6501;38.2681;20.4374;0.0732342;2.44025;37.5433;73.1342;38.3491;20.9825;14.1233;10.3013;26.858;26.6039;21.3695 80.8613;1.15962;2.99857;4.10872;143.428;8.82917;38.3264;40.8256;19.9134;89.8047;48.5666;81.7305;79.2355;150.579;41.5978;81.5688;35.2797;197.117;2.88499;23.4636;155.425;78.6415;32.1467;39.929;44.3296;101.869;36.4819;104.278;62.3571;46.6629;102.383;106.138;136.455;7.6286;46.9856;64.5991;70.4292;125.652;109.434;115.437;32.7581;105.243;30.4106;38.8511;49.9875;46.9257;31.9156;113.972;107.32;4.70178;133.304;245.492;22.3625;22.6149;102.888;34.8042;1.73689;19.0606;69.1421;109.848;110.58;36.7081;21.9073;15.4235;37.2719;45.3228;35.0407 21 46 21 257644;293615;25106;81819;25591;24314;24539;63868;113965;81869;29328;299626;24360;29496;116636;65210;29184;246142;50559;25287;170465 ZWINT_10214;SIRT3_9828;RGN_9699;PAX8_9432;PARP1_9425;NQO1_33055;LPL_32544;HSPD1_8849;HADH_8776;GSTM7_8761;GPX4_32827;GADD45B_8679;FABP1_33091;ERBB3_8571;EIF4EBP1_8550;CYP2J4_32580;CD36_8243;BMF_8152;ACOT1_7968;ACADL_32776;ACAA2_7955 51.343375238095234 45.9204 27.283832218683592 35.923385238095236 34.2198 17.044981135207404 77.62736523809524 70.4292 45.59797290827607 52.0003;2.38018;77.4407;56.8931;26.9741;87.2765;74.2041;42.2579;33.3125;42.3152;45.9204;106.367;33.8478;60.9984;83.9001;17.8395;48.1296;94.8767;31.2018;33.4878;26.5872 38.9015;0.56209;58.7732;45.1162;21.799;60.6992;49.8682;23.9469;25.7336;31.4035;34.2198;52.7132;26.4736;41.6036;42.4185;14.6501;37.5433;73.1342;26.858;26.6039;21.3695 80.8613;8.82917;89.8047;81.5688;35.2797;197.117;155.425;102.383;46.9856;64.5991;70.4292;109.434;46.9257;113.972;107.32;22.6149;69.1421;109.848;37.2719;45.3228;35.0407 46 79426;24522;308843;246273;79224;24794;24648;252922;83516;29441;85253;25513;25493;24567;299282;288001;24516;81678;54404;50693;306251;192235;65164;24471;24464;25675;29455;25112;294515;25661;246186;361969;83928;24890;24330;116663;140942;25428;25423;113936;25695;114851;79431;25698;25377;25373 ZFP36_10204;ZFP354A_10203;TSKU_10094;TRIB3_10079;SERPIND1_9812;SERPINA3C_32925;SERPINA1_9807;PZP_9633;PPARGC1A_33189;POR_9531;PLG_9501;PIK3R1_32562;NFKBIA_9307;MT1A_9255;LOC299282_9119;KNG1L1_34113;JUN_8938;ITPR2_8931;ITIH4_32725;ITIH3_32422;ITIH1_33132;HYOU1_8857;HTRA1_8856;HSPB1_8847;HP_8823;HMGCR_8810;GDF15_33113;GADD45A_8678;FOXO3_8662;FN1_8655;FGL1_8640;FGA_8632;FETUB_33027;ESR1_33192;EGR1_8533;DUSP6_8506;DDIT4_8450;CYP7A1_8430;CTSC_32456;CPB2_8369;CEBPD_8283;CDKN1A_8271;BHLHE40_8141;ASS1_33159;AMBP_33085;AHSG_8003 35.77772315217392 27.69285 31.203057397310136 24.77114728695652 21.246650000000002 22.478994570809256 59.890421086956515 40.377300000000005 51.85757242139965 0.348134;0.834827;1.38416;108.064;28.261;29.766;15.797;34.1871;42.4094;12.4414;70.7857;18.7324;0.520151;12.9315;45.2017;24.3655;16.4324;31.8111;57.1163;27.1247;98.1741;40.1982;33.1323;89.1011;64.9285;1.63089;105.149;102.919;13.1992;59.5777;15.4757;28.5803;32.5155;23.3972;0.750017;62.3934;87.5421;5.72128;56.2386;25.8316;0.306936;6.24967;57.8085;26.8037;17.2343;12.402 0.118102;0.27095;0.540568;83.8836;22.307;23.347;13.013;26.3085;26.2988;8.48981;46.2356;11.6701;0.160202;8.91033;30.7472;19.538;10.5224;24.7342;39.6402;21.5108;42.9071;29.3844;25.6145;60.3265;41.6103;0.663137;85.3487;89.5012;5.6804;31.0499;10.2138;22.529;19.6094;18.3088;0.186019;39.0875;53.2453;0.985273;38.2681;20.4374;0.0732342;2.44025;38.3491;20.9825;14.1233;10.3013 1.15962;2.99857;4.10872;143.428;38.3264;40.8256;19.9134;48.5666;81.7305;79.2355;150.579;41.5978;2.88499;23.4636;78.6415;32.1467;39.929;44.3296;101.869;36.4819;104.278;62.3571;46.6629;106.138;136.455;7.6286;125.652;115.437;32.7581;105.243;30.4106;38.8511;49.9875;31.9156;4.70178;133.304;245.492;22.3625;102.888;34.8042;1.73689;19.0606;110.58;36.7081;21.9073;15.4235 0 Exp 2,24(0.36);Exp 3,3(0.05);Exp 4,4(0.06);Hill,7(0.11);Linear,15(0.23);Poly 2,12(0.18);Power,2(0.03) 2.0569510103020603 475.47001349925995 1.511321783065796 344.14306640625 41.80663885234857 1.7033517360687256 33.30589093501568 48.00712831871566 23.132425199062723 33.400824508399964 53.39999231131771 77.49953127077177 DOWN 0.31343283582089554 0.6865671641791045 0.0 GO:0090407 5 organophosphate biosynthetic process 89 97 18 18 11 16 10 10 152 87 2298 0.95889 0.085053 0.13161 10.31 298490;24651;25513;294103;100359982;25675;298541;497840;362866;25028 ppcs;pklr;pik3r1;papss2;mpc2;hmgcr;dhdds;cps1;chpt1;ampd1 PPCS_9540;PKLR_9489;PIK3R1_32562;PAPSS2_33237;MPC2_33219;HMGCR_8810;DHDDS_8467;CPS1_32421;CHPT1_33298;AMPD1_32743 30.197229 27.539450000000002 1.63089 17.799594412943765 32.69367980806865 17.317548816450607 22.9846237 20.97305 0.663137 14.688586476825968 25.115371008983516 14.680448957875129 45.7601 43.593450000000004 7.6286 23.2927572602396 48.60674749475372 22.18200516785526 3.5 21.7158 8.5 54.42415 20.3353;23.0963;18.7324;34.4443;46.8463;1.63089;47.9438;31.9826;16.0559;60.9045 16.7643;17.4625;11.6701;25.719;35.8494;0.663137;36.5688;24.4836;10.6021;50.0633 25.6711;32.9443;41.5978;51.1014;69.127;7.6286;71.3742;45.5891;29.905;82.6625 5 5 5 298490;100359982;298541;362866;25028 PPCS_9540;MPC2_33219;DHDDS_8467;CHPT1_33298;AMPD1_32743 38.41716 46.8463 19.329170578118447 29.96958 35.8494 16.05738360309673 55.74795999999999 69.127 26.07703319154618 20.3353;46.8463;47.9438;16.0559;60.9045 16.7643;35.8494;36.5688;10.6021;50.0633 25.6711;69.127;71.3742;29.905;82.6625 5 24651;25513;294103;25675;497840 PKLR_9489;PIK3R1_32562;PAPSS2_33237;HMGCR_8810;CPS1_32421 21.977297999999998 23.0963 13.05076677812534 15.999667399999998 17.4625 10.2778491955717 35.77224 41.5978 17.068631703888858 23.0963;18.7324;34.4443;1.63089;31.9826 17.4625;11.6701;25.719;0.663137;24.4836 32.9443;41.5978;51.1014;7.6286;45.5891 0 Exp 2,7(0.7);Exp 4,1(0.1);Poly 2,2(0.2) 1.884744783063691 19.113505005836487 1.571676254272461 2.6967689990997314 0.35693428753843537 1.816131591796875 19.164926084666448 41.22953191533355 13.880543480476849 32.088703919523155 31.323099478155015 60.19710052184497 CONFLICT 0.5 0.5 0.0 GO:1901617 5 organic hydroxy compound biosynthetic process 60 64 20 20 13 14 9 9 153 55 2330 0.99378 0.018177 0.018177 14.06 293688;65192;29540;25675;24443;25315;298541;25428;25284 tm7sf2;slc27a2;hsd17b7;hmgcr;hdc;ephx1;dhdds;cyp7a1;amacr TM7SF2_10031;SLC27A2_9860;HSD17B7_8834;HMGCR_8810;HDC_8788;EPHX1_8567;DHDDS_8467;CYP7A1_8430;AMACR_8038 20.587999333333332 7.62189 0.977494 27.65144966126603 20.261523241460758 27.474678760169798 13.82665577777778 5.49916 0.322682 18.576849104134027 13.226038772074855 17.865711727620162 42.97721444444445 22.3625 3.73641 65.86407566062913 43.46515553748788 68.16060608381173 2.5 3.87951 5.5 18.5246 82.3097;7.62189;0.977494;1.63089;24.5745;12.4747;47.9438;5.72128;2.03774 51.1696;5.49916;0.322682;0.663137;21.0619;7.00435;36.5688;0.985273;1.165 209.842;13.3925;5.49472;7.6286;29.28;23.684;71.3742;22.3625;3.73641 5 4 5 65192;24443;25315;298541;25284 SLC27A2_9860;HDC_8788;EPHX1_8567;DHDDS_8467;AMACR_8038 18.930526 12.4747 18.224665066032905 14.259842 7.00435 14.532929852177778 28.293422 23.684 25.99643175143312 7.62189;24.5745;12.4747;47.9438;2.03774 5.49916;21.0619;7.00435;36.5688;1.165 13.3925;29.28;23.684;71.3742;3.73641 4 293688;29540;25675;25428 TM7SF2_10031;HSD17B7_8834;HMGCR_8810;CYP7A1_8430 22.659841 3.676085 39.82194319325051 13.285173 0.824205 25.257733567092583 61.33195500000001 14.99555 99.29031345772574 82.3097;0.977494;1.63089;5.72128 51.1696;0.322682;0.663137;0.985273 209.842;5.49472;7.6286;22.3625 0 Exp 2,2(0.23);Exp 4,3(0.34);Hill,3(0.34);Linear,1(0.12) 2.6534718253742926 35.34662473201752 1.5621941089630127 17.513065338134766 5.17730624329555 1.9017701148986816 2.5223855546395306 38.653613112027145 1.689781029743548 25.96353052581201 -0.05398165383324738 86.00841054272215 CONFLICT 0.5555555555555556 0.4444444444444444 0.0 GO:0050715 6 positive regulation of cytokine secretion 46 51 6 6 4 6 4 4 158 47 2338 0.77892 0.40937 0.56295 7.84 24539;63868;65210;29184 lpl;hspd1;cyp2j4;cd36 LPL_32544;HSPD1_8849;CYP2J4_32580;CD36_8243 45.607775000000004 45.19375 17.8395 23.140211493037384 47.27546697835275 23.513813234192245 31.502125 30.7451 14.6501 15.436759997783433 33.00480130011529 15.572300007757852 87.39125 85.76255 22.6149 55.92361070296398 89.25091407390804 56.9925352569299 1.5 45.19375 74.2041;42.2579;17.8395;48.1296 49.8682;23.9469;14.6501;37.5433 155.425;102.383;22.6149;69.1421 4 0 4 24539;63868;65210;29184 LPL_32544;HSPD1_8849;CYP2J4_32580;CD36_8243 45.607775000000004 45.19375 23.140211493037384 31.502125 30.7451 15.436759997783433 87.39125 85.76255 55.92361070296398 74.2041;42.2579;17.8395;48.1296 49.8682;23.9469;14.6501;37.5433 155.425;102.383;22.6149;69.1421 0 0 Exp 2,2(0.5);Exp 3,1(0.25);Linear,1(0.25) 2.4444903788212464 10.289540529251099 1.559399127960205 3.8079800605773926 0.9425439474739371 2.4610806703567505 22.93036773682335 68.28518226317664 16.374100202172244 46.63014979782776 32.586111511095304 142.1963884889047 UP 1.0 0.0 0.0 GO:0050793 4 regulation of developmental process 584 616 49 49 40 42 35 35 127 581 1804 0.24501 0.81176 0.50677 5.68 79426;246273;24825;360268;24794;25106;83516;29441;25513;81819;25591;25493;24539;307582;24516;24471;25675;24957;29455;25112;294515;314322;25661;24890;29496;24330;116663;25423;113936;25695;114851;29184;79431;155423;25373 zfp36;trib3;tf;sult1e1;serpina3c;rgn;ppargc1a;por;pik3r1;pax8;parp1;nfkbia;lpl;lama3;jun;hspb1;hmgcr;glul;gdf15;gadd45a;foxo3;fos;fn1;esr1;erbb3;egr1;dusp6;ctsc;cpb2;cebpd;cdkn1a;cd36;bhlhe40;anxa7;ahsg ZFP36_10204;TRIB3_10079;TF_10003;SULT1E1_32446;SERPINA3C_32925;RGN_9699;PPARGC1A_33189;POR_9531;PIK3R1_32562;PAX8_9432;PARP1_9425;NFKBIA_9307;LPL_32544;LAMA3_8980;JUN_8938;HSPB1_8847;HMGCR_8810;GLUL_32832;GDF15_33113;GADD45A_8678;FOXO3_8662;FOS_8657;FN1_8655;ESR1_33192;ERBB3_8571;EGR1_8533;DUSP6_8506;CTSC_32456;CPB2_8369;CEBPD_8283;CDKN1A_8271;CD36_8243;BHLHE40_8141;ANXA7_8051;AHSG_8003 40.54923794285719 29.766 1.28141E-12 34.48288554276783 48.46846996827717 34.12270781979283 28.276870148571465 23.347 1.28141E-12 25.41117361114812 34.04618395293515 26.019019692360015 63.43726514285719 61.5341 1.28142E-12 47.004064738877595 75.02882209720447 45.531051093157096 29.5 83.27090000000001 0.348134;108.064;45.1539;50.1846;29.766;77.4407;42.4094;12.4414;18.7324;56.8931;26.9741;0.520151;74.2041;2.46923;16.4324;89.1011;1.63089;26.4669;105.149;102.919;13.1992;1.28141E-12;59.5777;23.3972;60.9984;0.750017;62.3934;56.2386;25.8316;0.306936;6.24967;48.1296;57.8085;104.64;12.402 0.118102;83.8836;28.132;36.5009;23.347;58.7732;26.2988;8.48981;11.6701;45.1162;21.799;0.160202;49.8682;0.871501;10.5224;60.3265;0.663137;21.0456;85.3487;89.5012;5.6804;1.28141E-12;31.0499;18.3088;41.6036;0.186019;39.0875;38.2681;20.4374;0.0732342;2.44025;37.5433;38.3491;43.9254;10.3013 1.15962;143.428;61.5341;80.9788;40.8256;89.8047;81.7305;79.2355;41.5978;81.5688;35.2797;2.88499;155.425;10.4175;39.929;106.138;7.6286;35.4303;125.652;115.437;32.7581;1.28142E-12;105.243;31.9156;113.972;4.70178;133.304;102.888;34.8042;1.73689;19.0606;69.1421;110.58;108.689;15.4235 9 26 9 24825;360268;25106;81819;25591;24539;29496;29184;155423 TF_10003;SULT1E1_32446;RGN_9699;PAX8_9432;PARP1_9425;LPL_32544;ERBB3_8571;CD36_8243;ANXA7_8051 60.51316666666667 56.8931 22.514742038717642 40.36242222222222 41.6036 11.085987562772418 88.48824444444443 81.5688 34.597639909649615 45.1539;50.1846;77.4407;56.8931;26.9741;74.2041;60.9984;48.1296;104.64 28.132;36.5009;58.7732;45.1162;21.799;49.8682;41.6036;37.5433;43.9254 61.5341;80.9788;89.8047;81.5688;35.2797;155.425;113.972;69.1421;108.689 26 79426;246273;24794;83516;29441;25513;25493;307582;24516;24471;25675;24957;29455;25112;294515;314322;25661;24890;24330;116663;25423;113936;25695;114851;79431;25373 ZFP36_10204;TRIB3_10079;SERPINA3C_32925;PPARGC1A_33189;POR_9531;PIK3R1_32562;NFKBIA_9307;LAMA3_8980;JUN_8938;HSPB1_8847;HMGCR_8810;GLUL_32832;GDF15_33113;GADD45A_8678;FOXO3_8662;FOS_8657;FN1_8655;ESR1_33192;EGR1_8533;DUSP6_8506;CTSC_32456;CPB2_8369;CEBPD_8283;CDKN1A_8271;BHLHE40_8141;AHSG_8003 33.63864723076928 21.064799999999998 35.52146486562025 24.093409815384668 14.989450000000001 27.714234879901017 54.765772307692366 37.67965 48.14145382316446 0.348134;108.064;29.766;42.4094;12.4414;18.7324;0.520151;2.46923;16.4324;89.1011;1.63089;26.4669;105.149;102.919;13.1992;1.28141E-12;59.5777;23.3972;0.750017;62.3934;56.2386;25.8316;0.306936;6.24967;57.8085;12.402 0.118102;83.8836;23.347;26.2988;8.48981;11.6701;0.160202;0.871501;10.5224;60.3265;0.663137;21.0456;85.3487;89.5012;5.6804;1.28141E-12;31.0499;18.3088;0.186019;39.0875;38.2681;20.4374;0.0732342;2.44025;38.3491;10.3013 1.15962;143.428;40.8256;81.7305;79.2355;41.5978;2.88499;10.4175;39.929;106.138;7.6286;35.4303;125.652;115.437;32.7581;1.28142E-12;105.243;31.9156;4.70178;133.304;102.888;34.8042;1.73689;19.0606;110.58;15.4235 0 Exp 2,12(0.35);Exp 3,1(0.03);Exp 4,5(0.15);Hill,4(0.12);Linear,3(0.09);Poly 2,9(0.26);Power,1(0.03) 1.8652046870809325 67.1373987197876 1.522104263305664 4.21828556060791 0.5485791429089211 1.7521979808807373 29.125041829596796 51.97343405611757 19.858136442489588 36.69560385465335 47.86479650384713 79.00973378186723 DOWN 0.2571428571428571 0.7428571428571429 0.0 GO:0006796 5 phosphate-containing compound metabolic process 383 419 48 48 31 41 26 26 136 393 1992 0.49546 0.59154 1.0 6.21 79426;246273;24825;360268;192280;298490;24651;25513;294103;100359982;25675;29496;65030;116663;298541;83842;497840;362866;114851;54232;25028;192272;170570;50559;170465;296925 zfp36;trib3;tf;sult1e1;ppp1r3b;ppcs;pklr;pik3r1;papss2;mpc2;hmgcr;erbb3;ephx2;dusp6;dhdds;crot;cps1;chpt1;cdkn1a;car3;ampd1;acot2;acot12;acot1;acaa2;aass ZFP36_10204;TRIB3_10079;TF_10003;SULT1E1_32446;PPP1R3B_9545;PPCS_9540;PKLR_9489;PIK3R1_32562;PAPSS2_33237;MPC2_33219;HMGCR_8810;ERBB3_8571;EPHX2_33282;DUSP6_8506;DHDDS_8467;CROT_8384;CPS1_32421;CHPT1_33298;CDKN1A_8271;CAR3_8196;AMPD1_32743;ACOT2_7969;ACOT12_32718;ACOT1_7968;ACAA2_7955;AASS_7936 34.452501692307685 31.5922 0.348134 23.831569815885306 36.3337106451077 21.28737675194207 25.12811226923077 25.101300000000002 0.118102 17.82489692915666 26.352642480511655 15.864211827834442 52.69522000000001 43.593450000000004 1.15962 36.682887410669274 55.0464558863486 33.21037226446511 19.5 49.0642 0.348134;108.064;45.1539;50.1846;36.1411;20.3353;23.0963;18.7324;34.4443;46.8463;1.63089;60.9984;38.7293;62.3934;47.9438;7.4229;31.9826;16.0559;6.24967;53.9626;60.9045;8.54905;30.3423;31.2018;26.5872;27.4644 0.118102;83.8836;28.132;36.5009;27.0588;16.7643;17.4625;11.6701;25.719;35.8494;0.663137;41.6036;29.2097;39.0875;36.5688;5.75707;24.4836;10.6021;2.44025;28.5034;50.0633;7.19676;24.0157;26.858;21.3695;21.7498 1.15962;143.428;61.5341;80.9788;53.6244;25.6711;32.9443;41.5978;51.1014;69.127;7.6286;113.972;57.2113;133.304;71.3742;10.316;45.5891;29.905;19.0606;77.0288;82.6625;10.4125;41.1025;37.2719;35.0407;37.0295 15 11 15 24825;360268;298490;100359982;29496;65030;298541;83842;362866;25028;192272;170570;50559;170465;296925 TF_10003;SULT1E1_32446;PPCS_9540;MPC2_33219;ERBB3_8571;EPHX2_33282;DHDDS_8467;CROT_8384;CHPT1_33298;AMPD1_32743;ACOT2_7969;ACOT12_32718;ACOT1_7968;ACAA2_7955;AASS_7936 34.581309999999995 31.2018 17.31545787728618 26.149395333333338 26.858 12.778099392621993 50.907273333333336 41.1025 29.13663673890575 45.1539;50.1846;20.3353;46.8463;60.9984;38.7293;47.9438;7.4229;16.0559;60.9045;8.54905;30.3423;31.2018;26.5872;27.4644 28.132;36.5009;16.7643;35.8494;41.6036;29.2097;36.5688;5.75707;10.6021;50.0633;7.19676;24.0157;26.858;21.3695;21.7498 61.5341;80.9788;25.6711;69.127;113.972;57.2113;71.3742;10.316;29.905;82.6625;10.4125;41.1025;37.2719;35.0407;37.0295 11 79426;246273;192280;24651;25513;294103;25675;116663;497840;114851;54232 ZFP36_10204;TRIB3_10079;PPP1R3B_9545;PKLR_9489;PIK3R1_32562;PAPSS2_33237;HMGCR_8810;DUSP6_8506;CPS1_32421;CDKN1A_8271;CAR3_8196 34.276854 31.9826 31.623493812832383 23.73545354545455 24.4836 23.70712225927671 55.13332909090909 45.5891 46.52129176909547 0.348134;108.064;36.1411;23.0963;18.7324;34.4443;1.63089;62.3934;31.9826;6.24967;53.9626 0.118102;83.8836;27.0588;17.4625;11.6701;25.719;0.663137;39.0875;24.4836;2.44025;28.5034 1.15962;143.428;53.6244;32.9443;41.5978;51.1014;7.6286;133.304;45.5891;19.0606;77.0288 0 Exp 2,13(0.5);Exp 4,2(0.08);Hill,1(0.04);Linear,4(0.16);Poly 2,6(0.24) 2.7220103011002568 410.10983657836914 1.522104263305664 344.14306640625 67.0090196518032 1.878517508506775 25.291941173835916 43.613062210779454 18.2764424750647 31.979782063396843 38.59477203480838 66.79566796519165 CONFLICT 0.5769230769230769 0.4230769230769231 0.0 GO:0034284 6 response to monosaccharide 105 109 19 18 14 17 13 13 149 96 2289 0.99204 0.018827 0.024596 11.93 29573;25351;83516;24651;25513;24464;24957;294515;25661;24330;25428;113936;367313 slc37a4;slc2a2;ppargc1a;pklr;pik3r1;hp;glul;foxo3;fn1;egr1;cyp7a1;cpb2;col6a3 SLC37A4_9871;SLC2A2_9863;PPARGC1A_33189;PKLR_9489;PIK3R1_32562;HP_8823;GLUL_32832;FOXO3_8662;FN1_8655;EGR1_8533;CYP7A1_8430;CPB2_8369;COL6A3_33029 31.79364592307692 26.4669 0.750017 21.07718927387867 40.36205994706413 22.232955617755763 20.39294553846154 21.0456 0.186019 13.523291875200393 25.240957920680316 13.774537338754572 57.69368307692308 40.808 4.70178 40.75193516279593 73.76338554411832 44.71320208588802 4.5 24.46395 9.5 50.99355 39.7166;29.7555;42.4094;23.0963;18.7324;64.9285;26.4669;13.1992;59.5777;0.750017;5.72128;25.8316;63.132 22.6911;23.3399;26.2988;17.4625;11.6701;41.6103;21.0456;5.6804;31.0499;0.186019;0.985273;20.4374;42.651 60.0334;40.808;81.7305;32.9443;41.5978;136.455;35.4303;32.7581;105.243;4.70178;22.3625;34.8042;121.149 0 13 0 13 29573;25351;83516;24651;25513;24464;24957;294515;25661;24330;25428;113936;367313 SLC37A4_9871;SLC2A2_9863;PPARGC1A_33189;PKLR_9489;PIK3R1_32562;HP_8823;GLUL_32832;FOXO3_8662;FN1_8655;EGR1_8533;CYP7A1_8430;CPB2_8369;COL6A3_33029 31.79364592307692 26.4669 21.07718927387867 20.39294553846154 21.0456 13.523291875200393 57.69368307692308 40.808 40.75193516279593 39.7166;29.7555;42.4094;23.0963;18.7324;64.9285;26.4669;13.1992;59.5777;0.750017;5.72128;25.8316;63.132 22.6911;23.3399;26.2988;17.4625;11.6701;41.6103;21.0456;5.6804;31.0499;0.186019;0.985273;20.4374;42.651 60.0334;40.808;81.7305;32.9443;41.5978;136.455;35.4303;32.7581;105.243;4.70178;22.3625;34.8042;121.149 0 Exp 2,4(0.31);Exp 4,1(0.08);Hill,2(0.16);Linear,3(0.24);Poly 2,2(0.16);Power,1(0.08) 2.1259756168996526 29.557212233543396 1.5630855560302734 4.560328960418701 0.9932206319294813 1.7792335748672485 20.335955317502066 43.25133652865178 13.041600334812529 27.74429074211055 35.54067877418959 79.84668737965659 DOWN 0.0 1.0 0.0 GO:0071222 6 cellular response to lipopolysaccharide 81 86 10 10 9 10 9 9 153 77 2308 0.95649 0.092468 0.1149 10.47 79426;83516;81525;24516;25661;25146;29184;25698;25303 zfp36;ppargc1a;nfkbib;jun;fn1;cyp17a1;cd36;ass1;abcc2 ZFP36_10204;PPARGC1A_33189;NFKBIB_9308;JUN_8938;FN1_8655;CYP17A1_32365;CD36_8243;ASS1_33159;ABCC2_32541 35.575770444444444 42.4094 0.348134 18.717639772884336 39.925059118371635 16.350785278980357 24.17812244444444 26.2988 0.118102 12.180380083332121 26.821457924886648 9.735193697229219 59.844346666666674 69.1421 1.15962 32.21820918019963 65.57329024149138 29.88331967976032 3.5 36.4833 7.5 54.63495 0.348134;42.4094;30.5572;16.4324;59.5777;49.6922;48.1296;26.8037;46.2316 0.118102;26.2988;24.2439;10.5224;31.0499;35.6654;37.5433;20.9825;31.1788 1.15962;81.7305;41.2611;39.929;105.243;81.6409;69.1421;36.7081;81.7848 3 6 3 81525;25146;29184 NFKBIB_9308;CYP17A1_32365;CD36_8243 42.793000000000006 48.1296 10.625277922012174 32.4842 35.6654 7.19781461069955 64.0147 69.1421 20.67243902107344 30.5572;49.6922;48.1296 24.2439;35.6654;37.5433 41.2611;81.6409;69.1421 6 79426;83516;24516;25661;25698;25303 ZFP36_10204;PPARGC1A_33189;JUN_8938;FN1_8655;ASS1_33159;ABCC2_32541 31.967155666666667 34.60655 21.645366416120392 20.025083666666664 23.64065 12.432353291637137 57.759170000000005 60.829750000000004 38.39568007188048 0.348134;42.4094;16.4324;59.5777;26.8037;46.2316 0.118102;26.2988;10.5224;31.0499;20.9825;31.1788 1.15962;81.7305;39.929;105.243;36.7081;81.7848 0 Exp 2,5(0.56);Hill,1(0.12);Linear,1(0.12);Poly 2,1(0.12);Power,1(0.12) 1.9029566491525076 17.30386173725128 1.5302108526229858 2.6703107357025146 0.31026165010472356 1.8814297914505005 23.34691245949334 47.80462842939555 16.220274123334125 32.13597076555476 38.79511666893624 80.8935766643971 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0043065 8 positive regulation of apoptotic process 196 210 19 19 17 16 14 14 148 196 2189 0.64394 0.46879 0.8823 6.67 24794;83516;24314;24516;63868;25675;299626;25112;289388;294515;24330;116663;25423;246142 serpina3c;ppargc1a;nqo1;jun;hspd1;hmgcr;gadd45b;gadd45a;g0s2;foxo3;egr1;dusp6;ctsc;bmf SERPINA3C_32925;PPARGC1A_33189;NQO1_33055;JUN_8938;HSPD1_8849;HMGCR_8810;GADD45B_8679;GADD45A_8678;G0S2_32729;FOXO3_8662;EGR1_8533;DUSP6_8506;CTSC_32456;BMF_8152 50.206814785714286 44.3939 0.750017 36.54221471026472 56.99323244920931 35.75813478869509 34.13138971428572 30.0451 0.186019 27.175483874965813 41.322338521551124 29.96894138574483 82.25981999999999 92.05675 4.70178 53.23890589431237 86.89447913514525 42.886713995761305 9.5 74.83494999999999 29.766;42.4094;87.2765;16.4324;42.2579;1.63089;106.367;102.919;46.3784;13.1992;0.750017;62.3934;56.2386;94.8767 23.347;26.2988;60.6992;10.5224;23.9469;0.663137;52.7132;89.5012;33.7914;5.6804;0.186019;39.0875;38.2681;73.1342 40.8256;81.7305;197.117;39.929;102.383;7.6286;109.434;115.437;73.6529;32.7581;4.70178;133.304;102.888;109.848 5 9 5 24314;63868;299626;289388;246142 NQO1_33055;HSPD1_8849;GADD45B_8679;G0S2_32729;BMF_8152 75.4313 87.2765 29.24036313326155 48.85698 52.7132 19.94978574125548 118.48697999999999 109.434 46.39154386525632 87.2765;42.2579;106.367;46.3784;94.8767 60.6992;23.9469;52.7132;33.7914;73.1342 197.117;102.383;109.434;73.6529;109.848 9 24794;83516;24516;25675;25112;294515;24330;116663;25423 SERPINA3C_32925;PPARGC1A_33189;JUN_8938;HMGCR_8810;GADD45A_8678;FOXO3_8662;EGR1_8533;DUSP6_8506;CTSC_32456 36.19321188888889 29.766 33.52338123509157 25.95050622222222 23.347 28.111513359082032 62.13362 40.8256 47.47452210871743 29.766;42.4094;16.4324;1.63089;102.919;13.1992;0.750017;62.3934;56.2386 23.347;26.2988;10.5224;0.663137;89.5012;5.6804;0.186019;39.0875;38.2681 40.8256;81.7305;39.929;7.6286;115.437;32.7581;4.70178;133.304;102.888 0 Exp 2,4(0.29);Exp 3,1(0.08);Exp 4,2(0.15);Hill,1(0.08);Linear,2(0.15);Poly 2,3(0.22);Power,1(0.08) 1.9018728700551792 27.67574977874756 1.5527137517929077 4.21828556060791 0.6899438200527187 1.729400396347046 31.06483212175049 69.34879744967807 19.896000717096634 48.36677871147479 54.37157562954971 110.14806437045033 DOWN 0.35714285714285715 0.6428571428571429 0.0 GO:0000278 4 mitotic cell cycle 41 47 1 1 1 1 1 1 161 46 2339 0.18829 0.95575 0.36384 2.13 296554 tubb4b TUBB4B_34097 62.7603 62.7603 62.7603 62.7603 47.0916 47.0916 47.0916 47.0916 101.528 101.528 101.528 101.528 62.7603 47.0916 101.528 1 0 1 296554 TUBB4B_34097 62.7603 62.7603 47.0916 47.0916 101.528 101.528 62.7603 47.0916 101.528 0 0 Exp 2,1(1) 1.6439030170440674 1.6439030170440674 1.6439030170440674 1.6439030170440674 0.0 1.6439030170440674 62.7603 62.7603 47.0916 47.0916 101.528 101.528 UP 1.0 0.0 0.0 GO:0051348 6 negative regulation of transferase activity 84 91 11 11 10 11 10 10 152 81 2304 0.9728 0.060161 0.076941 10.99 79426;246273;25106;24471;25675;299626;25112;116663;114851;25373 zfp36;trib3;rgn;hspb1;hmgcr;gadd45b;gadd45a;dusp6;cdkn1a;ahsg ZFP36_10204;TRIB3_10079;RGN_9699;HSPB1_8847;HMGCR_8810;GADD45B_8679;GADD45A_8678;DUSP6_8506;CDKN1A_8271;AHSG_8003 56.6915894 69.91705 0.348134 46.51090390538191 62.29203941011142 44.03638464249229 39.78079889999999 45.90035 0.118102 34.53567976370921 46.13750980489235 35.450716847941734 74.08180200000001 97.97135 1.15962 56.5221739344956 81.34561884937588 52.01704933411525 3.5 37.3977 8.5 107.21549999999999 0.348134;108.064;77.4407;89.1011;1.63089;106.367;102.919;62.3934;6.24967;12.402 0.118102;83.8836;58.7732;60.3265;0.663137;52.7132;89.5012;39.0875;2.44025;10.3013 1.15962;143.428;89.8047;106.138;7.6286;109.434;115.437;133.304;19.0606;15.4235 2 8 2 25106;299626 RGN_9699;GADD45B_8679 91.90385 91.90385 20.45398288463645 55.7432 55.7432 4.285067093990547 99.61935 99.61935 13.880011139945033 77.4407;106.367 58.7732;52.7132 89.8047;109.434 8 79426;246273;24471;25675;25112;116663;114851;25373 ZFP36_10204;TRIB3_10079;HSPB1_8847;HMGCR_8810;GADD45A_8678;DUSP6_8506;CDKN1A_8271;AHSG_8003 47.88852425 37.3977 47.73626052385612 35.790198625 24.694399999999998 37.94556471066726 67.697415 62.5993 62.02503493711989 0.348134;108.064;89.1011;1.63089;102.919;62.3934;6.24967;12.402 0.118102;83.8836;60.3265;0.663137;89.5012;39.0875;2.44025;10.3013 1.15962;143.428;106.138;7.6286;115.437;133.304;19.0606;15.4235 0 Exp 2,2(0.2);Exp 4,2(0.2);Hill,1(0.1);Poly 2,4(0.4);Power,1(0.1) 1.8370746232287596 18.910197019577026 1.522104263305664 3.431420087814331 0.5601570968825367 1.7086020708084106 27.86383249465142 85.51934630534858 18.37536281528067 61.186234984719334 39.04899564430746 109.11460835569255 DOWN 0.2 0.8 0.0 GO:0046916 9 cellular transition metal ion homeostasis 20 23 6 6 5 3 2 2 160 21 2364 0.82335 0.43545 0.65454 8.7 24825;24567 tf;mt1 TF_10003;MT1A_9255 29.0427 29.0427 12.9315 22.784677546105407 37.74934717022683 19.17107511294977 18.521165 18.521165 8.91033 13.59177320273003 23.71495251156133 11.436146263665457 42.498850000000004 42.498850000000004 23.4636 26.919908713162442 52.78568186522793 22.650467224277357 0.5 29.0427 45.1539;12.9315 28.132;8.91033 61.5341;23.4636 1 1 1 24825 TF_10003 45.1539 45.1539 28.132 28.132 61.5341 61.5341 45.1539 28.132 61.5341 1 24567 MT1A_9255 12.9315 12.9315 8.91033 8.91033 23.4636 23.4636 12.9315 8.91033 23.4636 0 Poly 2,2(1) 2.0421697452855736 4.1078550815582275 1.8344712257385254 2.273383855819702 0.3103580970788227 2.0539275407791138 -2.5352519999999963 60.62065199999999 -0.3160716000000008 37.3584016 5.189760000000007 79.80794 CONFLICT 0.5 0.5 0.0 GO:0015712 7 hexose phosphate transport 1 1 1 1 1 1 1 1 161 0 2385 1.0 0.063604 0.063604 100.0 29573 slc37a4 SLC37A4_9871 39.7166 39.7166 39.7166 39.7166 22.6911 22.6911 22.6911 22.6911 60.0334 60.0334 60.0334 60.0334 0.0 39.7166 0.0 39.7166 39.7166 22.6911 60.0334 0 1 0 1 29573 SLC37A4_9871 39.7166 39.7166 22.6911 22.6911 60.0334 60.0334 39.7166 22.6911 60.0334 0 Poly 2,1(1) 1.893584966659546 1.893584966659546 1.893584966659546 1.893584966659546 0.0 1.893584966659546 39.7166 39.7166 22.6911 22.6911 60.0334 60.0334 DOWN 0.0 1.0 0.0 GO:0015760 7 glucose-6-phosphate transport 1 1 1 1 1 1 1 1 161 0 2385 1.0 0.063604 0.063604 100.0 29573 slc37a4 SLC37A4_9871 39.7166 39.7166 39.7166 39.7166 22.6911 22.6911 22.6911 22.6911 60.0334 60.0334 60.0334 60.0334 0.0 39.7166 0.0 39.7166 39.7166 22.6911 60.0334 0 1 0 1 29573 SLC37A4_9871 39.7166 39.7166 22.6911 22.6911 60.0334 60.0334 39.7166 22.6911 60.0334 0 Poly 2,1(1) 1.893584966659546 1.893584966659546 1.893584966659546 1.893584966659546 0.0 1.893584966659546 39.7166 39.7166 22.6911 22.6911 60.0334 60.0334 DOWN 0.0 1.0 0.0 GO:0045670 8 regulation of osteoclast differentiation 23 26 2 2 2 2 2 2 160 24 2361 0.7731 0.50003 0.67957 7.69 25513;314322 pik3r1;fos PIK3R1_32562;FOS_8657 9.36620000000064 9.36620000000064 1.28141E-12 13.245807067897973 10.732516701903295 13.10411241634395 5.83505000000064 5.83505000000064 1.28141E-12 8.252006847124223 6.686251797040716 8.163732480086333 20.79890000000064 20.79890000000064 1.28142E-12 29.414086462440864 23.83298900634304 29.099434534422336 0.5 9.36620000000064 18.7324;1.28141E-12 11.6701;1.28141E-12 41.5978;1.28142E-12 0 2 0 2 25513;314322 PIK3R1_32562;FOS_8657 9.36620000000064 9.36620000000064 13.245807067897973 5.83505000000064 5.83505000000064 8.252006847124223 20.79890000000064 20.79890000000064 29.414086462440864 18.7324;1.28141E-12 11.6701;1.28141E-12 41.5978;1.28142E-12 0 Hill,1(0.5);Poly 2,1(0.5) 1.7816357806023322 3.570248246192932 1.6735800504684448 1.8966681957244873 0.15774714031287715 1.785124123096466 -8.9915519999981 27.72395199999938 -5.601647999998104 17.271747999999384 -19.966943999998104 61.56474399999938 DOWN 0.0 1.0 0.0 GO:0019438 5 aromatic compound biosynthetic process 165 183 21 21 15 18 13 13 149 170 2215 0.72927 0.37954 0.63721 7.1 298490;303612;24651;81819;294103;100359982;24516;24443;294515;314322;24890;24330;25028 ppcs;polg2;pklr;pax8;papss2;mpc2;jun;hdc;foxo3;fos;esr1;egr1;ampd1 PPCS_9540;POLG2_9521;PKLR_9489;PAX8_9432;PAPSS2_33237;MPC2_33219;JUN_8938;HDC_8788;FOXO3_8662;FOS_8657;ESR1_33192;EGR1_8533;AMPD1_32743 29.58837823076933 23.3972 1.28141E-12 21.518378368266298 34.258081166295 23.53554314477851 22.129963000000096 18.3088 1.28141E-12 16.600825874537357 26.082696379792402 18.48236321198886 47.24819846153856 32.9443 1.28142E-12 36.21595467964389 53.4348564403 37.57683449600661 8.5 40.6453 20.3353;63.7758;23.0963;56.8931;34.4443;46.8463;16.4324;24.5745;13.1992;1.28141E-12;23.3972;0.750017;60.9045 16.7643;40.9553;17.4625;45.1162;25.719;35.8494;10.5224;21.0619;5.6804;1.28141E-12;18.3088;0.186019;50.0633 25.6711;132.567;32.9443;81.5688;51.1014;69.127;39.929;29.28;32.7581;1.28142E-12;31.9156;4.70178;82.6625 5 8 5 298490;81819;100359982;24443;25028 PPCS_9540;PAX8_9432;MPC2_33219;HDC_8788;AMPD1_32743 41.91074 46.8463 18.54480123344547 33.77102 35.8494 14.570701909894392 57.66188 69.127 28.093424133718553 20.3353;56.8931;46.8463;24.5745;60.9045 16.7643;45.1162;35.8494;21.0619;50.0633 25.6711;81.5688;69.127;29.28;82.6625 8 303612;24651;294103;24516;294515;314322;24890;24330 POLG2_9521;PKLR_9489;PAPSS2_33237;JUN_8938;FOXO3_8662;FOS_8657;ESR1_33192;EGR1_8533 21.88690212500016 19.76435 20.518785151053297 14.85430237500016 13.992449999999998 13.922103080994615 40.73964750000016 32.8512 40.88497604114368 63.7758;23.0963;34.4443;16.4324;13.1992;1.28141E-12;23.3972;0.750017 40.9553;17.4625;25.719;10.5224;5.6804;1.28141E-12;18.3088;0.186019 132.567;32.9443;51.1014;39.929;32.7581;1.28142E-12;31.9156;4.70178 0 Exp 2,9(0.7);Exp 4,1(0.08);Hill,2(0.16);Poly 2,1(0.08) 2.469957025461347 43.70269000530243 1.5504547357559204 17.513065338134766 4.308769326153092 1.9785058498382568 17.890854501509803 41.28590196002885 13.105651257295502 31.154274742704697 27.560981237601727 66.93541568547539 DOWN 0.38461538461538464 0.6153846153846154 0.0 GO:1903532 6 positive regulation of secretion by cell 132 141 15 15 10 13 9 9 153 132 2253 0.59219 0.54791 1.0 6.38 293615;100359982;24539;63868;24957;361969;65210;113936;29184 sirt3;mpc2;lpl;hspd1;glul;fga;cyp2j4;cpb2;cd36 SIRT3_9828;MPC2_33219;LPL_32544;HSPD1_8849;GLUL_32832;FGA_8632;CYP2J4_32580;CPB2_8369;CD36_8243 34.726264444444446 28.5803 2.38018 20.791544940260636 37.95080439304073 22.05028046330757 25.15911 22.529 0.56209 14.323253455784762 27.330014177540527 14.994240016138596 59.622974444444445 38.8511 8.82917 45.784446202863236 66.52694834160106 49.599427672534354 6.5 47.48795 2.38018;46.8463;74.2041;42.2579;26.4669;28.5803;17.8395;25.8316;48.1296 0.56209;35.8494;49.8682;23.9469;21.0456;22.529;14.6501;20.4374;37.5433 8.82917;69.127;155.425;102.383;35.4303;38.8511;22.6149;34.8042;69.1421 6 3 6 293615;100359982;24539;63868;65210;29184 SIRT3_9828;MPC2_33219;LPL_32544;HSPD1_8849;CYP2J4_32580;CD36_8243 38.60959666666667 44.552099999999996 25.229823929533616 27.06999833333333 29.89815 17.738110173736573 71.25352833333334 69.13454999999999 53.526400179003424 2.38018;46.8463;74.2041;42.2579;17.8395;48.1296 0.56209;35.8494;49.8682;23.9469;14.6501;37.5433 8.82917;69.127;155.425;102.383;22.6149;69.1421 3 24957;361969;113936 GLUL_32832;FGA_8632;CPB2_8369 26.959600000000005 26.4669 1.439063198751133 21.337333333333333 21.0456 1.075885167354434 36.361866666666664 35.4303 2.1783508081421425 26.4669;28.5803;25.8316 21.0456;22.529;20.4374 35.4303;38.8511;34.8042 0 Exp 2,4(0.45);Exp 3,1(0.12);Hill,1(0.12);Linear,3(0.34) 2.033439019872515 19.20013988018036 1.5209722518920898 3.8079800605773926 0.7568942934287305 1.9223796129226685 21.142455083474154 48.31007380541471 15.80125107555396 34.51696892444605 29.71046959190713 89.53547929698176 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0010288 6 response to lead ion 24 26 3 3 3 3 3 3 159 23 2362 0.92111 0.2269 0.2269 11.54 24825;24648;24464 tf;serpina1;hp TF_10003;SERPINA1_9807;HP_8823 41.9598 45.1539 15.797 24.72099874944376 52.11112595608192 17.957201609367743 27.5851 28.132 13.013 14.30649211127591 33.30057321120157 10.99953260092837 72.63416666666667 61.5341 19.9134 59.05840111824339 93.96415877744882 51.976557016520125 0.5 30.475450000000002 1.5 55.0412 45.1539;15.797;64.9285 28.132;13.013;41.6103 61.5341;19.9134;136.455 1 2 1 24825 TF_10003 45.1539 45.1539 28.132 28.132 61.5341 61.5341 45.1539 28.132 61.5341 2 24648;24464 SERPINA1_9807;HP_8823 40.36275 40.36275 34.741216819866864 27.31165 27.31165 20.221344753626056 78.1842 78.1842 82.40735565033015 15.797;64.9285 13.013;41.6103 19.9134;136.455 0 Exp 2,2(0.67);Poly 2,1(0.34) 1.7218250715563144 5.171445965766907 1.6336230039596558 1.8344712257385254 0.10197583442867005 1.7033517360687256 13.9853564460496 69.93424355395041 11.395780139655361 43.774419860344636 5.803294450954283 139.46503888237908 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0080090 5 regulation of primary metabolic process 955 1029 87 87 71 75 62 62 100 967 1418 0.31412 0.74233 0.6198 6.03 79426;24522;246273;25357;24825;293615;79224;24794;24648;25106;252922;192280;83516;29441;303612;363465;25513;81819;25591;81525;25493;299282;288001;58954;24516;54404;50693;306251;494344;63868;24471;25675;290556;29455;299626;25112;294515;314322;25661;246186;361969;83928;24360;24890;29496;65030;116636;24330;116663;140942;25428;25146;25423;113936;25695;114851;29184;79431;25377;25373;24158;25287 zfp36;zfp354a;trib3;thrsp;tf;sirt3;serpind1;serpina3c;serpina1;rgn;pzp;ppp1r3b;ppargc1a;por;polg2;pir;pik3r1;pax8;parp1;nfkbib;nfkbia;loc299282;kng1;klf6;jun;itih4;itih3;itih1;ier2;hspd1;hspb1;hmgcr;gnl3;gdf15;gadd45b;gadd45a;foxo3;fos;fn1;fgl1;fga;fetub;fabp1;esr1;erbb3;ephx2;eif4ebp1;egr1;dusp6;ddit4;cyp7a1;cyp17a1;ctsc;cpb2;cebpd;cdkn1a;cd36;bhlhe40;ambp;ahsg;acadm;acadl ZFP36_10204;ZFP354A_10203;TRIB3_10079;THRSP_33314;TF_10003;SIRT3_9828;SERPIND1_9812;SERPINA3C_32925;SERPINA1_9807;RGN_9699;PZP_9633;PPP1R3B_9545;PPARGC1A_33189;POR_9531;POLG2_9521;PIR_9487;PIK3R1_32562;PAX8_9432;PARP1_9425;NFKBIB_9308;NFKBIA_9307;LOC299282_9119;KNG1L1_34113;KLF6_8969;JUN_8938;ITIH4_32725;ITIH3_32422;ITIH1_33132;IER2_32643;HSPD1_8849;HSPB1_8847;HMGCR_8810;GNL3_8735;GDF15_33113;GADD45B_8679;GADD45A_8678;FOXO3_8662;FOS_8657;FN1_8655;FGL1_8640;FGA_8632;FETUB_33027;FABP1_33091;ESR1_33192;ERBB3_8571;EPHX2_33282;EIF4EBP1_8550;EGR1_8533;DUSP6_8506;DDIT4_8450;CYP7A1_8430;CYP17A1_32365;CTSC_32456;CPB2_8369;CEBPD_8283;CDKN1A_8271;CD36_8243;BHLHE40_8141;AMBP_33085;AHSG_8003;ACADM_7957;ACADL_32776 39.52807556451615 33.00165 1.28141E-12 30.53981384700445 42.645909007534705 29.82206106919445 27.022185116129048 24.32025 1.28141E-12 21.091907958151324 29.389960780448988 21.522583853751957 64.52656322580648 47.74615 1.28142E-12 51.14775791428567 66.36004048224616 42.43812963307718 50.5 63.084599999999995 0.348134;0.834827;108.064;32.2053;45.1539;2.38018;28.261;29.766;15.797;77.4407;34.1871;36.1411;42.4094;12.4414;63.7758;50.0307;18.7324;56.8931;26.9741;30.5572;0.520151;45.2017;24.3655;18.9476;16.4324;57.1163;27.1247;98.1741;49.6814;42.2579;89.1011;1.63089;87.6357;105.149;106.367;102.919;13.1992;1.28141E-12;59.5777;15.4757;28.5803;32.5155;33.8478;23.3972;60.9984;38.7293;83.9001;0.750017;62.3934;87.5421;5.72128;49.6922;56.2386;25.8316;0.306936;6.24967;48.1296;57.8085;17.2343;12.402;11.7137;33.4878 0.118102;0.27095;83.8836;24.3966;28.132;0.56209;22.307;23.347;13.013;58.7732;26.3085;27.0588;26.2988;8.48981;40.9553;38.7717;11.6701;45.1162;21.799;24.2439;0.160202;30.7472;19.538;11.6941;10.5224;39.6402;21.5108;42.9071;33.4626;23.9469;60.3265;0.663137;54.41;85.3487;52.7132;89.5012;5.6804;1.28141E-12;31.0499;10.2138;22.529;19.6094;26.4736;18.3088;41.6036;29.2097;42.4185;0.186019;39.0875;53.2453;0.985273;35.6654;38.2681;20.4374;0.0732342;2.44025;37.5433;38.3491;14.1233;10.3013;8.36151;26.6039 1.15962;2.99857;143.428;46.6068;61.5341;8.82917;38.3264;40.8256;19.9134;89.8047;48.5666;53.6244;81.7305;79.2355;132.567;73.0083;41.5978;81.5688;35.2797;41.2611;2.88499;78.6415;32.1467;45.5481;39.929;101.869;36.4819;104.278;89.4404;102.383;106.138;7.6286;238.963;125.652;109.434;115.437;32.7581;1.28142E-12;105.243;30.4106;38.8511;49.9875;46.9257;31.9156;113.972;57.2113;107.32;4.70178;133.304;245.492;22.3625;81.6409;102.888;34.8042;1.73689;19.0606;69.1421;110.58;21.9073;15.4235;18.9642;45.3228 18 44 18 24825;293615;25106;363465;81819;25591;81525;63868;290556;299626;24360;29496;65030;116636;25146;29184;24158;25287 TF_10003;SIRT3_9828;RGN_9699;PIR_9487;PAX8_9432;PARP1_9425;NFKBIB_9308;HSPD1_8849;GNL3_8735;GADD45B_8679;FABP1_33091;ERBB3_8571;EPHX2_33282;EIF4EBP1_8550;CYP17A1_32365;CD36_8243;ACADM_7957;ACADL_32776 49.23274333333333 46.64175 26.616086661958025 33.130427777777776 32.43755 15.236319052348557 76.80915944444445 71.0752 50.915077107220355 45.1539;2.38018;77.4407;50.0307;56.8931;26.9741;30.5572;42.2579;87.6357;106.367;33.8478;60.9984;38.7293;83.9001;49.6922;48.1296;11.7137;33.4878 28.132;0.56209;58.7732;38.7717;45.1162;21.799;24.2439;23.9469;54.41;52.7132;26.4736;41.6036;29.2097;42.4185;35.6654;37.5433;8.36151;26.6039 61.5341;8.82917;89.8047;73.0083;81.5688;35.2797;41.2611;102.383;238.963;109.434;46.9257;113.972;57.2113;107.32;81.6409;69.1421;18.9642;45.3228 44 79426;24522;246273;25357;79224;24794;24648;252922;192280;83516;29441;303612;25513;25493;299282;288001;58954;24516;54404;50693;306251;494344;24471;25675;29455;25112;294515;314322;25661;246186;361969;83928;24890;24330;116663;140942;25428;25423;113936;25695;114851;79431;25377;25373 ZFP36_10204;ZFP354A_10203;TRIB3_10079;THRSP_33314;SERPIND1_9812;SERPINA3C_32925;SERPINA1_9807;PZP_9633;PPP1R3B_9545;PPARGC1A_33189;POR_9531;POLG2_9521;PIK3R1_32562;NFKBIA_9307;LOC299282_9119;KNG1L1_34113;KLF6_8969;JUN_8938;ITIH4_32725;ITIH3_32422;ITIH1_33132;IER2_32643;HSPB1_8847;HMGCR_8810;GDF15_33113;GADD45A_8678;FOXO3_8662;FOS_8657;FN1_8655;FGL1_8640;FGA_8632;FETUB_33027;ESR1_33192;EGR1_8533;DUSP6_8506;DDIT4_8450;CYP7A1_8430;CTSC_32456;CPB2_8369;CEBPD_8283;CDKN1A_8271;BHLHE40_8141;AMBP_33085;AHSG_8003 35.55798420454549 27.69285 31.42420151141894 24.523358572727304 20.9741 22.744372234220457 59.501864772727295 41.2117 50.96405527550543 0.348134;0.834827;108.064;32.2053;28.261;29.766;15.797;34.1871;36.1411;42.4094;12.4414;63.7758;18.7324;0.520151;45.2017;24.3655;18.9476;16.4324;57.1163;27.1247;98.1741;49.6814;89.1011;1.63089;105.149;102.919;13.1992;1.28141E-12;59.5777;15.4757;28.5803;32.5155;23.3972;0.750017;62.3934;87.5421;5.72128;56.2386;25.8316;0.306936;6.24967;57.8085;17.2343;12.402 0.118102;0.27095;83.8836;24.3966;22.307;23.347;13.013;26.3085;27.0588;26.2988;8.48981;40.9553;11.6701;0.160202;30.7472;19.538;11.6941;10.5224;39.6402;21.5108;42.9071;33.4626;60.3265;0.663137;85.3487;89.5012;5.6804;1.28141E-12;31.0499;10.2138;22.529;19.6094;18.3088;0.186019;39.0875;53.2453;0.985273;38.2681;20.4374;0.0732342;2.44025;38.3491;14.1233;10.3013 1.15962;2.99857;143.428;46.6068;38.3264;40.8256;19.9134;48.5666;53.6244;81.7305;79.2355;132.567;41.5978;2.88499;78.6415;32.1467;45.5481;39.929;101.869;36.4819;104.278;89.4404;106.138;7.6286;125.652;115.437;32.7581;1.28142E-12;105.243;30.4106;38.8511;49.9875;31.9156;4.70178;133.304;245.492;22.3625;102.888;34.8042;1.73689;19.0606;110.58;21.9073;15.4235 0 Exp 2,22(0.36);Exp 3,3(0.05);Exp 4,4(0.07);Hill,7(0.12);Linear,11(0.18);Poly 2,13(0.21);Power,2(0.04) 1.9150361642573717 124.49907433986664 1.511321783065796 4.642963409423828 0.756082375551481 1.7360422611236572 31.926097499737946 47.130053629294366 21.771982136980427 32.272388095277684 51.79485059406348 77.25827585754946 DOWN 0.2903225806451613 0.7096774193548387 0.0 GO:0034504 7 protein localization to nucleus 39 40 5 5 4 5 4 4 158 36 2349 0.8935 0.24762 0.31829 10.0 297784;25513;25493;114851 rrs1;pik3r1;nfkbia;cdkn1a RRS1_9755;PIK3R1_32562;NFKBIA_9307;CDKN1A_8271 21.47305525 12.491035 0.520151 27.03587391382969 20.973451913381393 26.079914978564137 14.344888000000001 7.055175 0.160202 19.811228742164783 13.620951739580988 19.448665600287864 42.1213475 30.3292 2.88499 44.78838505549206 42.40120134377112 41.92983257870509 1.0 6.24967 3.0 60.39 60.39;18.7324;0.520151;6.24967 43.109;11.6701;0.160202;2.44025 104.942;41.5978;2.88499;19.0606 1 3 1 297784 RRS1_9755 60.39 60.39 43.109 43.109 104.942 104.942 60.39 43.109 104.942 3 25513;25493;114851 PIK3R1_32562;NFKBIA_9307;CDKN1A_8271 8.500740333333333 6.24967 9.312464316372456 4.756850666666666 2.44025 6.094621971804432 21.18113 19.0606 19.44332533633843 18.7324;0.520151;6.24967 11.6701;0.160202;2.44025 41.5978;2.88499;19.0606 0 Exp 2,1(0.25);Exp 4,2(0.5);Poly 2,1(0.25) 1.812017477571096 7.3322447538375854 1.522104263305664 2.281954288482666 0.3286830506533394 1.7640931010246277 -5.0221011855530975 47.9682116855531 -5.070116167321487 33.75989216732149 -1.7712698543822185 86.01396485438221 DOWN 0.25 0.75 0.0 GO:0010556 6 regulation of macromolecule biosynthetic process 567 609 45 45 35 37 30 30 132 579 1806 0.05572 0.96351 0.10562 4.93 79426;24522;246273;24825;293615;25106;192280;83516;303612;363465;25513;81819;25591;81525;25493;58954;24516;494344;24471;290556;25112;294515;314322;24890;116636;24330;25695;114851;29184;79431 zfp36;zfp354a;trib3;tf;sirt3;rgn;ppp1r3b;ppargc1a;polg2;pir;pik3r1;pax8;parp1;nfkbib;nfkbia;klf6;jun;ier2;hspb1;gnl3;gadd45a;foxo3;fos;esr1;eif4ebp1;egr1;cebpd;cdkn1a;cd36;bhlhe40 ZFP36_10204;ZFP354A_10203;TRIB3_10079;TF_10003;SIRT3_9828;RGN_9699;PPP1R3B_9545;PPARGC1A_33189;POLG2_9521;PIR_9487;PIK3R1_32562;PAX8_9432;PARP1_9425;NFKBIB_9308;NFKBIA_9307;KLF6_8969;JUN_8938;IER2_32643;HSPB1_8847;GNL3_8735;GADD45A_8678;FOXO3_8662;FOS_8657;ESR1_33192;EIF4EBP1_8550;EGR1_8533;CEBPD_8283;CDKN1A_8271;CD36_8243;BHLHE40_8141 38.623803833333376 33.34915 1.28141E-12 33.55812985389722 40.77050486829446 32.70478323752832 27.09101157333338 25.271349999999998 1.28141E-12 25.006402682532595 29.374848762760895 25.212329451446205 62.13157733333336 49.58625 1.28142E-12 54.097392907883965 59.90060977706407 43.552389240505654 0.348134;0.834827;108.064;45.1539;2.38018;77.4407;36.1411;42.4094;63.7758;50.0307;18.7324;56.8931;26.9741;30.5572;0.520151;18.9476;16.4324;49.6814;89.1011;87.6357;102.919;13.1992;1.28141E-12;23.3972;83.9001;0.750017;0.306936;6.24967;48.1296;57.8085 0.118102;0.27095;83.8836;28.132;0.56209;58.7732;27.0588;26.2988;40.9553;38.7717;11.6701;45.1162;21.799;24.2439;0.160202;11.6941;10.5224;33.4626;60.3265;54.41;89.5012;5.6804;1.28141E-12;18.3088;42.4185;0.186019;0.0732342;2.44025;37.5433;38.3491 1.15962;2.99857;143.428;61.5341;8.82917;89.8047;53.6244;81.7305;132.567;73.0083;41.5978;81.5688;35.2797;41.2611;2.88499;45.5481;39.929;89.4404;106.138;238.963;115.437;32.7581;1.28142E-12;31.9156;107.32;4.70178;1.73689;19.0606;69.1421;110.58 10 20 10 24825;293615;25106;363465;81819;25591;81525;290556;116636;29184 TF_10003;SIRT3_9828;RGN_9699;PIR_9487;PAX8_9432;PARP1_9425;NFKBIB_9308;GNL3_8735;EIF4EBP1_8550;CD36_8243 50.909528 49.08015 26.999471085590134 35.176989000000006 38.1575 17.13594268400937 80.67109699999999 71.0752 62.52410140186372 45.1539;2.38018;77.4407;50.0307;56.8931;26.9741;30.5572;87.6357;83.9001;48.1296 28.132;0.56209;58.7732;38.7717;45.1162;21.799;24.2439;54.41;42.4185;37.5433 61.5341;8.82917;89.8047;73.0083;81.5688;35.2797;41.2611;238.963;107.32;69.1421 20 79426;24522;246273;192280;83516;303612;25513;25493;58954;24516;494344;24471;25112;294515;314322;24890;24330;25695;114851;79431 ZFP36_10204;ZFP354A_10203;TRIB3_10079;PPP1R3B_9545;PPARGC1A_33189;POLG2_9521;PIK3R1_32562;NFKBIA_9307;KLF6_8969;JUN_8938;IER2_32643;HSPB1_8847;GADD45A_8678;FOXO3_8662;FOS_8657;ESR1_33192;EGR1_8533;CEBPD_8283;CDKN1A_8271;BHLHE40_8141 32.48094175000006 18.84 35.41741028515571 23.048022860000064 11.6821 27.63557473649623 52.86181750000007 40.763400000000004 48.41173928773759 0.348134;0.834827;108.064;36.1411;42.4094;63.7758;18.7324;0.520151;18.9476;16.4324;49.6814;89.1011;102.919;13.1992;1.28141E-12;23.3972;0.750017;0.306936;6.24967;57.8085 0.118102;0.27095;83.8836;27.0588;26.2988;40.9553;11.6701;0.160202;11.6941;10.5224;33.4626;60.3265;89.5012;5.6804;1.28141E-12;18.3088;0.186019;0.0732342;2.44025;38.3491 1.15962;2.99857;143.428;53.6244;81.7305;132.567;41.5978;2.88499;45.5481;39.929;89.4404;106.138;115.437;32.7581;1.28142E-12;31.9156;4.70178;1.73689;19.0606;110.58 0 Exp 2,12(0.4);Exp 3,1(0.04);Exp 4,3(0.1);Hill,6(0.2);Poly 2,8(0.27) 1.8931374944219022 59.154582500457764 1.5209722518920898 4.591650485992432 0.7083283971199857 1.7612056136131287 26.615181290337567 50.632426376329185 18.14258529689659 36.03943784977017 42.7730739000596 81.49008076660716 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0006475 9 internal protein amino acid acetylation 15 15 3 3 2 3 2 2 160 13 2372 0.93468 0.24652 0.24652 13.33 29441;171142 por;ehhadh POR_9531;EHHADH_8534 10.534745000000001 10.534745000000001 8.62809 2.696417359766468 10.447064006203956 2.693564676168715 7.90423 7.90423 7.31865 0.8281351778544445 7.87730103993796 0.8272590495243777 44.8132 44.8132 10.3909 48.68048350807539 43.230228003101985 48.628981830736215 0.0 8.62809 0.5 10.534745000000001 12.4414;8.62809 8.48981;7.31865 79.2355;10.3909 1 1 1 171142 EHHADH_8534 8.62809 8.62809 7.31865 7.31865 10.3909 10.3909 8.62809 7.31865 10.3909 1 29441 POR_9531 12.4414 12.4414 8.48981 8.48981 79.2355 79.2355 12.4414 8.48981 79.2355 0 Exp 2,1(0.5);Poly 2,1(0.5) 8.05455538564966 34.71563935279846 1.9819281101226807 32.73371124267578 21.744794386606387 17.35781967639923 6.797701200000001 14.2717888 6.7564931999999995 9.0519668 -22.654508 112.28090800000001 CONFLICT 0.5 0.5 0.0 GO:0043524 8 negative regulation of neuron apoptotic process 75 76 9 9 7 8 6 6 156 70 2315 0.79427 0.35324 0.48022 7.89 83516;24567;24516;192235;63868;29496 ppargc1a;mt1;jun;hyou1;hspd1;erbb3 PPARGC1A_33189;MT1A_9255;JUN_8938;HYOU1_8857;HSPD1_8849;ERBB3_8571 35.8713 41.228049999999996 12.9315 18.09825343197513 40.63152058047493 16.848254542394876 23.444405 25.12285 8.91033 12.26097487979443 26.185003799849227 11.693514899294863 70.6392 72.0438 23.4636 35.343073238698416 81.542866049755 32.586231246249575 2.5 41.228049999999996 42.4094;12.9315;16.4324;40.1982;42.2579;60.9984 26.2988;8.91033;10.5224;29.3844;23.9469;41.6036 81.7305;23.4636;39.929;62.3571;102.383;113.972 2 4 2 63868;29496 HSPD1_8849;ERBB3_8571 51.62815 51.62815 13.251534632826507 32.77525 32.77525 12.48517230337651 108.1775 108.1775 8.194660487170758 42.2579;60.9984 23.9469;41.6036 102.383;113.972 4 83516;24567;24516;192235 PPARGC1A_33189;MT1A_9255;JUN_8938;HYOU1_8857 27.992874999999998 28.3153 15.46281292378051 18.778982499999998 18.4106 10.560681675088901 51.870050000000006 51.14305 25.50254738001677 42.4094;12.9315;16.4324;40.1982 26.2988;8.91033;10.5224;29.3844 81.7305;23.4636;39.929;62.3571 0 Exp 2,2(0.34);Exp 3,1(0.17);Linear,1(0.17);Poly 2,2(0.34) 1.9003364381142254 11.514757633209229 1.6013026237487793 2.273383855819702 0.29601773913470103 1.8680644631385803 21.389681192988235 50.35291880701176 13.63358181317097 33.25522818682903 42.358851510302046 98.91954848969796 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0016043 4 cellular component organization 805 877 49 48 38 43 33 33 129 844 1541 3.8817E-5 0.99998 7.5211E-5 3.76 257644;24522;296554;308843;171139;24825;29482;293615;297784;308821;83516;298699;303612;85253;25591;24539;307582;24516;306251;63868;85255;29328;25112;25661;361969;29496;140942;29184;155423;25373;50681;170465;312382 zwint;zfp354a;tubb4b;tsku;timm9;tf;slc1a2;sirt3;rrs1;rab30;ppargc1a;ppan;polg2;plg;parp1;lpl;lama3;jun;itih1;hspd1;hacl1;gpx4;gadd45a;fn1;fga;erbb3;ddit4;cd36;anxa7;ahsg;acox1;acaa2;abcg2 ZWINT_10214;ZFP354A_10203;TUBB4B_34097;TSKU_10094;TIMM9_10020;TF_10003;SLC1A2_33059;SIRT3_9828;RRS1_9755;RAB30_9639;PPARGC1A_33189;PPAN_9534;POLG2_9521;PLG_9501;PARP1_9425;LPL_32544;LAMA3_8980;JUN_8938;ITIH1_33132;HSPD1_8849;HACL1_8775;GPX4_32827;GADD45A_8678;FN1_8655;FGA_8632;ERBB3_8571;DDIT4_8450;CD36_8243;ANXA7_8051;AHSG_8003;ACOX1_7973;ACAA2_7955;ABCG2_32656 171139(0.04986) 43.08089506060606 42.4094 0.834827 30.12579843486777 45.254920589537164 30.374095331939518 28.440876030303034 28.132 0.27095 19.613797276338616 30.03544364788775 20.52724893862707 72.46301393939395 69.1421 2.99857 53.992588455044505 73.11089068667799 49.12603060242148 52.0003;0.834827;62.7603;1.38416;38.5191;45.1539;13.3235;2.38018;60.39;26.4203;42.4094;57.6889;63.7758;70.7857;26.9741;74.2041;2.46923;16.4324;98.1741;42.2579;17.6275;45.9204;102.919;59.5777;28.5803;60.9984;87.5421;48.1296;104.64;12.402;23.1906;26.5872;5.21654 38.9015;0.27095;47.0916;0.540568;29.55;28.132;9.10952;0.56209;43.109;21.0125;26.2988;41.3659;40.9553;46.2356;21.799;49.8682;0.871501;10.5224;42.9071;23.9469;11.195;34.2198;89.5012;31.0499;22.529;41.6036;53.2453;37.5433;43.9254;10.3013;16.2815;21.3695;2.73368 80.8613;2.99857;101.528;4.10872;55.4685;61.5341;24.6773;8.82917;104.942;35.3561;81.7305;98.1741;132.567;150.579;35.2797;155.425;10.4175;39.929;104.278;102.383;37.6534;70.4292;115.437;105.243;38.8511;113.972;245.492;69.1421;108.689;15.4235;33.4539;35.0407;11.386 19 14 19 257644;296554;171139;24825;293615;297784;308821;298699;25591;24539;63868;85255;29328;29496;29184;155423;50681;170465;312382 ZWINT_10214;TUBB4B_34097;TIMM9_10020;TF_10003;SIRT3_9828;RRS1_9755;RAB30_9639;PPAN_9534;PARP1_9425;LPL_32544;HSPD1_8849;HACL1_8775;GPX4_32827;ERBB3_8571;CD36_8243;ANXA7_8051;ACOX1_7973;ACAA2_7955;ABCG2_32656 43.21364842105263 45.1539 24.78894574867714 29.16897210526316 29.55 14.666663490351391 69.44985631578948 69.1421 39.69915998528225 52.0003;62.7603;38.5191;45.1539;2.38018;60.39;26.4203;57.6889;26.9741;74.2041;42.2579;17.6275;45.9204;60.9984;48.1296;104.64;23.1906;26.5872;5.21654 38.9015;47.0916;29.55;28.132;0.56209;43.109;21.0125;41.3659;21.799;49.8682;23.9469;11.195;34.2198;41.6036;37.5433;43.9254;16.2815;21.3695;2.73368 80.8613;101.528;55.4685;61.5341;8.82917;104.942;35.3561;98.1741;35.2797;155.425;102.383;37.6534;70.4292;113.972;69.1421;108.689;33.4539;35.0407;11.386 14 24522;308843;29482;83516;303612;85253;307582;24516;306251;25112;25661;361969;140942;25373 ZFP354A_10203;TSKU_10094;SLC1A2_33059;PPARGC1A_33189;POLG2_9521;PLG_9501;LAMA3_8980;JUN_8938;ITIH1_33132;GADD45A_8678;FN1_8655;FGA_8632;DDIT4_8450;AHSG_8003 42.90072978571429 35.49485 37.19015291492566 27.452745642857142 24.413899999999998 25.4417783227914 76.55229928571428 60.829750000000004 70.44438787021417 0.834827;1.38416;13.3235;42.4094;63.7758;70.7857;2.46923;16.4324;98.1741;102.919;59.5777;28.5803;87.5421;12.402 0.27095;0.540568;9.10952;26.2988;40.9553;46.2356;0.871501;10.5224;42.9071;89.5012;31.0499;22.529;53.2453;10.3013 2.99857;4.10872;24.6773;81.7305;132.567;150.579;10.4175;39.929;104.278;115.437;105.243;38.8511;245.492;15.4235 0 Exp 2,13(0.4);Exp 3,3(0.1);Exp 4,2(0.07);Hill,3(0.1);Linear,5(0.16);Poly 2,5(0.16);Power,2(0.07) 1.9657217827117424 69.50472283363342 1.5074360370635986 5.973292827606201 0.9783252767590623 1.6902168989181519 32.80220744494826 53.35958267626386 21.748801275962684 35.13295078464337 54.04116359441368 90.88486428437417 CONFLICT 0.5757575757575758 0.42424242424242425 0.0 GO:0034371 9 chylomicron remodeling 2 2 1 1 1 1 1 1 161 1 2384 0.99598 0.12319 0.12319 50.0 24539 lpl LPL_32544 74.2041 74.2041 74.2041 74.2041 49.8682 49.8682 49.8682 49.8682 155.425 155.425 155.425 155.425 0.0 74.2041 0.0 74.2041 74.2041 49.8682 155.425 1 0 1 24539 LPL_32544 74.2041 74.2041 49.8682 49.8682 155.425 155.425 74.2041 49.8682 155.425 0 0 Exp 2,1(1) 1.559399127960205 1.559399127960205 1.559399127960205 1.559399127960205 0.0 1.559399127960205 74.2041 74.2041 49.8682 49.8682 155.425 155.425 UP 1.0 0.0 0.0 GO:0045444 5 fat cell differentiation 31 34 5 5 3 5 3 3 159 31 2354 0.83336 0.36878 0.47423 8.82 246074;83516;25695 scd;ppargc1a;cebpd SCD1_9787;PPARGC1A_33189;CEBPD_8283 49.392112 42.4094 0.306936 52.9231557761178 42.898357642871474 50.26287705202585 30.04174473333333 26.2988 0.0732342 32.00455807427878 26.135381236274835 30.437969774598685 168.72213000000002 81.7305 1.73689 223.55744738535486 139.5399995229812 208.37690247420232 0.5 21.358168 105.46;42.4094;0.306936 63.7532;26.2988;0.0732342 422.699;81.7305;1.73689 1 2 1 246074 SCD1_9787 105.46 105.46 63.7532 63.7532 422.699 422.699 105.46 63.7532 422.699 2 83516;25695 PPARGC1A_33189;CEBPD_8283 21.358168 21.358168 29.770937799062494 13.1860171 13.1860171 18.544275417634005 41.733695000000004 41.733695000000004 56.56402408259203 42.4094;0.306936 26.2988;0.0732342 81.7305;1.73689 0 Exp 2,2(0.67);Hill,1(0.34) 1.8565698659995937 5.622153878211975 1.627708911895752 2.2368218898773193 0.3208135005719325 1.7576230764389038 -10.496076538063988 109.28030053806398 -6.174822096847201 66.25831156351387 -84.25693675746928 421.70119675746923 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0071398 6 cellular response to fatty acid 37 38 10 10 8 9 7 7 155 31 2354 0.99787 0.0087228 0.0087228 18.42 83516;25513;24539;24471;25661;497840;25698 ppargc1a;pik3r1;lpl;hspb1;fn1;cps1;ass1 PPARGC1A_33189;PIK3R1_32562;LPL_32544;HSPB1_8847;FN1_8655;CPS1_32421;ASS1_33159 48.973000000000006 42.4094 18.7324 26.131267244688548 54.44394824117312 24.80197902417217 32.09708571428572 26.2988 11.6701 17.059650126876235 35.113745958626104 16.333870274240056 81.7759285714286 81.7305 36.7081 43.82404115983651 91.90978820538561 44.31986191893066 0.5 22.76805 2.5 37.196 42.4094;18.7324;74.2041;89.1011;59.5777;31.9826;26.8037 26.2988;11.6701;49.8682;60.3265;31.0499;24.4836;20.9825 81.7305;41.5978;155.425;106.138;105.243;45.5891;36.7081 1 6 1 24539 LPL_32544 74.2041 74.2041 49.8682 49.8682 155.425 155.425 74.2041 49.8682 155.425 6 83516;25513;24471;25661;497840;25698 PPARGC1A_33189;PIK3R1_32562;HSPB1_8847;FN1_8655;CPS1_32421;ASS1_33159 44.76781666666667 37.196 25.9011542540804 29.135233333333336 25.391199999999998 16.59965092761491 69.50108333333334 63.659800000000004 32.23371782921828 42.4094;18.7324;89.1011;59.5777;31.9826;26.8037 26.2988;11.6701;60.3265;31.0499;24.4836;20.9825 81.7305;41.5978;106.138;105.243;45.5891;36.7081 0 Exp 2,4(0.58);Poly 2,2(0.29);Power,1(0.15) 1.736445140884018 12.175058722496033 1.559399127960205 1.8814297914505005 0.10659645734202904 1.7576230764389038 29.61468631972409 68.33131368027591 19.45912004122963 44.735051387341805 49.31062455208846 114.2412325907687 DOWN 0.14285714285714285 0.8571428571428571 0.0 GO:0006469 8 negative regulation of protein kinase activity 71 76 10 10 9 10 9 9 153 67 2318 0.97974 0.049039 0.055309 11.84 246273;25106;24471;25675;299626;25112;116663;114851;25373 trib3;rgn;hspb1;hmgcr;gadd45b;gadd45a;dusp6;cdkn1a;ahsg TRIB3_10079;RGN_9699;HSPB1_8847;HMGCR_8810;GADD45B_8679;GADD45A_8678;DUSP6_8506;CDKN1A_8271;AHSG_8003 62.951973333333335 77.4407 1.63089 44.640313912307164 65.42828440645148 42.81626359551923 44.187765222222225 52.7132 0.663137 33.51584866858734 48.46749104367725 34.78725671205634 82.18426666666667 106.138 7.6286 53.437242731333924 85.40546841815741 49.93519567552137 2.5 37.3977 6.5 104.643 108.064;77.4407;89.1011;1.63089;106.367;102.919;62.3934;6.24967;12.402 83.8836;58.7732;60.3265;0.663137;52.7132;89.5012;39.0875;2.44025;10.3013 143.428;89.8047;106.138;7.6286;109.434;115.437;133.304;19.0606;15.4235 2 7 2 25106;299626 RGN_9699;GADD45B_8679 91.90385 91.90385 20.45398288463645 55.7432 55.7432 4.285067093990547 99.61935 99.61935 13.880011139945033 77.4407;106.367 58.7732;52.7132 89.8047;109.434 7 246273;24471;25675;25112;116663;114851;25373 TRIB3_10079;HSPB1_8847;HMGCR_8810;GADD45A_8678;DUSP6_8506;CDKN1A_8271;AHSG_8003 54.680008571428566 62.3934 47.20221651128699 40.886212428571426 39.0875 37.91388750412657 77.2028142857143 106.138 60.37381916047243 108.064;89.1011;1.63089;102.919;62.3934;6.24967;12.402 83.8836;60.3265;0.663137;89.5012;39.0875;2.44025;10.3013 143.428;106.138;7.6286;115.437;133.304;19.0606;15.4235 0 Exp 2,2(0.23);Exp 4,2(0.23);Poly 2,4(0.45);Power,1(0.12) 1.8261717836971216 16.972020506858826 1.522104263305664 3.431420087814331 0.5938763453901664 1.6973176002502441 33.78696824395932 92.11697842270736 22.29074409207849 66.08478635236594 47.27193474886184 117.09659858447148 DOWN 0.2222222222222222 0.7777777777777778 0.0 GO:0046942 7 carboxylic acid transport 73 76 19 18 15 18 14 14 148 62 2323 0.99994 2.1745E-4 2.1745E-4 18.42 170698;65192;29482;29500;298199;100359982;24360;25428;83842;29184;65054;312382;140668;25303 slco1a2;slc27a2;slc1a2;slc10a2;plin2;mpc2;fabp1;cyp7a1;crot;cd36;aqp9;abcg2;abcc3;abcc2 SLCO1A2_9886;SLC27A2_9860;SLC1A2_33059;SLC10A2_9833;PLIN2_9502;MPC2_33219;FABP1_33091;CYP7A1_8430;CROT_8384;CD36_8243;AQP9_32709;ABCG2_32656;ABCC3_7941;ABCC2_32541 33.30315785714286 30.7897 5.21654 27.069505874242218 29.203632370598264 21.97185057728178 24.605900214285718 24.2054 0.985273 20.78178833602305 21.61696782004113 16.70826128120799 50.982771428571425 42.1941 10.316 37.831856139124724 45.64308175862014 33.68612632752783 2.5 7.5223949999999995 6.5 30.7897 104.197;7.62189;13.3235;56.585;25.6517;46.8463;33.8478;5.72128;7.4229;48.1296;27.7316;5.21654;37.7175;46.2316 80.3101;5.49916;9.10952;35.2796;20.9252;35.8494;26.4736;0.985273;5.75707;37.5433;21.9372;2.73368;30.9007;31.1788 128.412;13.3925;24.6773;116.8;33.0375;69.127;46.9257;22.3625;10.316;69.1421;37.4625;11.386;48.9329;81.7848 8 6 8 65192;298199;100359982;24360;83842;29184;312382;140668 SLC27A2_9860;PLIN2_9502;MPC2_33219;FABP1_33091;CROT_8384;CD36_8243;ABCG2_32656;ABCC3_7941 26.556778750000003 29.74975 17.871095035487922 20.710263750000003 23.6994 14.281781766674367 37.782462499999994 39.9816 24.618235628721454 7.62189;25.6517;46.8463;33.8478;7.4229;48.1296;5.21654;37.7175 5.49916;20.9252;35.8494;26.4736;5.75707;37.5433;2.73368;30.9007 13.3925;33.0375;69.127;46.9257;10.316;69.1421;11.386;48.9329 6 170698;29482;29500;25428;65054;25303 SLCO1A2_9886;SLC1A2_33059;SLC10A2_9833;CYP7A1_8430;AQP9_32709;ABCC2_32541 42.29833 36.9816 35.89048866614942 29.80008216666667 26.558 27.940670665266502 68.58318333333334 59.62365 47.140654399421166 104.197;13.3235;56.585;5.72128;27.7316;46.2316 80.3101;9.10952;35.2796;0.985273;21.9372;31.1788 128.412;24.6773;116.8;22.3625;37.4625;81.7848 0 Exp 2,7(0.5);Exp 4,1(0.08);Hill,2(0.15);Linear,1(0.08);Poly 2,3(0.22) 2.242709200576017 34.446266174316406 1.5074360370635986 5.963563919067383 1.2925903832101995 1.898861050605774 19.123283531647793 47.483032182637906 13.719733756986276 35.492066671585164 31.16523327160591 70.80030958553694 CONFLICT 0.5714285714285714 0.42857142857142855 0.0 GO:0009615 5 response to virus 66 68 5 5 4 3 3 3 159 65 2320 0.36173 0.81894 0.79887 4.41 24471;308441;140942 hspb1;exosc5;ddit4 HSPB1_8847;EXOSC5_32543;DDIT4_8450 72.8587 87.5421 41.9329 26.793869624972064 83.24505825843819 18.506835305360433 48.43513333333333 53.2453 31.7336 14.890995941283904 55.60380788895547 11.199332555220654 137.92243333333332 106.138 62.1373 95.72055241568205 127.58824266027563 72.24672338359949 89.1011;41.9329;87.5421 60.3265;31.7336;53.2453 106.138;62.1373;245.492 1 2 1 308441 EXOSC5_32543 41.9329 41.9329 31.7336 31.7336 62.1373 62.1373 41.9329 31.7336 62.1373 2 24471;140942 HSPB1_8847;DDIT4_8450 88.3216 88.3216 1.1023794718696955 56.7859 56.7859 5.007164538938235 175.815 175.815 98.53815838547007 89.1011;87.5421 60.3265;53.2453 106.138;245.492 0 Exp 2,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 1.6536425489806756 4.9625084400177 1.5979743003845215 1.6973176002502441 0.050940574455375164 1.6672165393829346 42.53858223240566 103.17881776759434 31.584385123537647 65.28588154312902 29.60443139315288 246.2404352735138 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0048565 5 digestive tract development 26 28 5 5 3 5 3 3 159 25 2360 0.90193 0.26178 0.41898 10.71 497840;29184;25698 cps1;cd36;ass1 CPS1_32421;CD36_8243;ASS1_33159 35.63863333333333 31.9826 26.8037 11.123103771130332 37.64434022840758 11.627909264220275 27.6698 24.4836 20.9825 8.72805402079984 29.254407850892377 9.140601344168047 50.47976666666667 45.5891 36.7081 16.760968180070442 53.477980407376286 17.48568866112664 0.5 29.39315 1.5 40.0561 31.9826;48.1296;26.8037 24.4836;37.5433;20.9825 45.5891;69.1421;36.7081 1 2 1 29184 CD36_8243 48.1296 48.1296 37.5433 37.5433 69.1421 69.1421 48.1296 37.5433 69.1421 2 497840;25698 CPS1_32421;ASS1_33159 29.39315 29.39315 3.662035309087031 22.73305 22.73305 2.4756515516122723 41.1486 41.1486 6.279815323717738 31.9826;26.8037 24.4836;20.9825 45.5891;36.7081 0 Exp 2,3(1) 2.093571944983518 6.378216028213501 1.8264755010604858 2.6703107357025146 0.4721248107332755 1.8814297914505005 23.051656498620325 48.22561016804634 17.793077096715663 37.546522903284334 31.512945665007543 69.4465876683258 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0019433 8 triglyceride catabolic process 5 7 3 3 2 3 2 2 160 5 2380 0.99269 0.068343 0.068343 28.57 24539;497840 lpl;cps1 LPL_32544;CPS1_32421 53.09335 53.09335 31.9826 29.855108961867817 57.70684243048403 29.13346711795104 37.1759 37.1759 24.4836 17.949622797708045 39.94964465499485 17.51575404479567 100.50705 100.50705 45.5891 77.66570970772753 112.50868644696189 75.78841540496089 0.0 31.9826 0.0 31.9826 74.2041;31.9826 49.8682;24.4836 155.425;45.5891 1 1 1 24539 LPL_32544 74.2041 74.2041 49.8682 49.8682 155.425 155.425 74.2041 49.8682 155.425 1 497840 CPS1_32421 31.9826 31.9826 24.4836 24.4836 45.5891 45.5891 31.9826 24.4836 45.5891 0 Exp 2,2(1) 1.6876623784378202 3.385874629020691 1.559399127960205 1.8264755010604858 0.18885151451391696 1.6929373145103455 11.716280000000012 94.47041999999999 12.298991999999998 62.052808 -7.132131999999984 208.146232 CONFLICT 0.5 0.5 0.0 GO:0009893 5 positive regulation of metabolic process 777 837 66 66 51 56 44 44 118 793 1592 0.063909 0.95555 0.11989 5.26 79426;246273;24825;293615;246074;25106;83516;29441;303612;25513;81819;25591;25493;24539;58954;24516;494344;63868;24471;25675;113965;290556;29455;299626;25112;289388;294515;314322;25661;361969;24360;24890;29496;65030;24330;25428;65210;25146;25423;25695;114851;29184;25698;25287 zfp36;trib3;tf;sirt3;scd;rgn;ppargc1a;por;polg2;pik3r1;pax8;parp1;nfkbia;lpl;klf6;jun;ier2;hspd1;hspb1;hmgcr;hadh;gnl3;gdf15;gadd45b;gadd45a;g0s2;foxo3;fos;fn1;fga;fabp1;esr1;erbb3;ephx2;egr1;cyp7a1;cyp2j4;cyp17a1;ctsc;cebpd;cdkn1a;cd36;ass1;acadl ZFP36_10204;TRIB3_10079;TF_10003;SIRT3_9828;SCD1_9787;RGN_9699;PPARGC1A_33189;POR_9531;POLG2_9521;PIK3R1_32562;PAX8_9432;PARP1_9425;NFKBIA_9307;LPL_32544;KLF6_8969;JUN_8938;IER2_32643;HSPD1_8849;HSPB1_8847;HMGCR_8810;HADH_8776;GNL3_8735;GDF15_33113;GADD45B_8679;GADD45A_8678;G0S2_32729;FOXO3_8662;FOS_8657;FN1_8655;FGA_8632;FABP1_33091;ESR1_33192;ERBB3_8571;EPHX2_33282;EGR1_8533;CYP7A1_8430;CYP2J4_32580;CYP17A1_32365;CTSC_32456;CEBPD_8283;CDKN1A_8271;CD36_8243;ASS1_33159;ACADL_32776 41.77635131818185 36.28855 1.28141E-12 33.49897408905274 45.23032409449112 31.50610166278728 28.953332209090934 26.386200000000002 1.28141E-12 24.157829402610588 32.15363272749037 24.007212970243756 74.36342840909094 59.3727 1.28142E-12 73.36772614308966 76.35136023623869 63.31092257338848 40.5 105.30449999999999 0.348134;108.064;45.1539;2.38018;105.46;77.4407;42.4094;12.4414;63.7758;18.7324;56.8931;26.9741;0.520151;74.2041;18.9476;16.4324;49.6814;42.2579;89.1011;1.63089;33.3125;87.6357;105.149;106.367;102.919;46.3784;13.1992;1.28141E-12;59.5777;28.5803;33.8478;23.3972;60.9984;38.7293;0.750017;5.72128;17.8395;49.6922;56.2386;0.306936;6.24967;48.1296;26.8037;33.4878 0.118102;83.8836;28.132;0.56209;63.7532;58.7732;26.2988;8.48981;40.9553;11.6701;45.1162;21.799;0.160202;49.8682;11.6941;10.5224;33.4626;23.9469;60.3265;0.663137;25.7336;54.41;85.3487;52.7132;89.5012;33.7914;5.6804;1.28141E-12;31.0499;22.529;26.4736;18.3088;41.6036;29.2097;0.186019;0.985273;14.6501;35.6654;38.2681;0.0732342;2.44025;37.5433;20.9825;26.6039 1.15962;143.428;61.5341;8.82917;422.699;89.8047;81.7305;79.2355;132.567;41.5978;81.5688;35.2797;2.88499;155.425;45.5481;39.929;89.4404;102.383;106.138;7.6286;46.9856;238.963;125.652;109.434;115.437;73.6529;32.7581;1.28142E-12;105.243;38.8511;46.9257;31.9156;113.972;57.2113;4.70178;22.3625;22.6149;81.6409;102.888;1.73689;19.0606;69.1421;36.7081;45.3228 19 25 19 24825;293615;246074;25106;81819;25591;24539;63868;113965;290556;299626;289388;24360;29496;65030;65210;25146;29184;25287 TF_10003;SIRT3_9828;SCD1_9787;RGN_9699;PAX8_9432;PARP1_9425;LPL_32544;HSPD1_8849;HADH_8776;GNL3_8735;GADD45B_8679;G0S2_32729;FABP1_33091;ERBB3_8571;EPHX2_33282;CYP2J4_32580;CYP17A1_32365;CD36_8243;ACADL_32776 51.956956842105264 46.3784 27.86411575535122 35.2815047368421 33.7914 16.09446826458927 98.07308789473684 73.6529 94.1572333692048 45.1539;2.38018;105.46;77.4407;56.8931;26.9741;74.2041;42.2579;33.3125;87.6357;106.367;46.3784;33.8478;60.9984;38.7293;17.8395;49.6922;48.1296;33.4878 28.132;0.56209;63.7532;58.7732;45.1162;21.799;49.8682;23.9469;25.7336;54.41;52.7132;33.7914;26.4736;41.6036;29.2097;14.6501;35.6654;37.5433;26.6039 61.5341;8.82917;422.699;89.8047;81.5688;35.2797;155.425;102.383;46.9856;238.963;109.434;73.6529;46.9257;113.972;57.2113;22.6149;81.6409;69.1421;45.3228 25 79426;246273;83516;29441;303612;25513;25493;58954;24516;494344;24471;25675;29455;25112;294515;314322;25661;361969;24890;24330;25428;25423;25695;114851;25698 ZFP36_10204;TRIB3_10079;PPARGC1A_33189;POR_9531;POLG2_9521;PIK3R1_32562;NFKBIA_9307;KLF6_8969;JUN_8938;IER2_32643;HSPB1_8847;HMGCR_8810;GDF15_33113;GADD45A_8678;FOXO3_8662;FOS_8657;FN1_8655;FGA_8632;ESR1_33192;EGR1_8533;CYP7A1_8430;CTSC_32456;CEBPD_8283;CDKN1A_8271;ASS1_33159 34.03909112000005 18.9476 35.83094194775474 24.143921088000052 11.6941 28.205441406634478 56.34408720000005 39.929 47.029533728518565 0.348134;108.064;42.4094;12.4414;63.7758;18.7324;0.520151;18.9476;16.4324;49.6814;89.1011;1.63089;105.149;102.919;13.1992;1.28141E-12;59.5777;28.5803;23.3972;0.750017;5.72128;56.2386;0.306936;6.24967;26.8037 0.118102;83.8836;26.2988;8.48981;40.9553;11.6701;0.160202;11.6941;10.5224;33.4626;60.3265;0.663137;85.3487;89.5012;5.6804;1.28141E-12;31.0499;22.529;18.3088;0.186019;0.985273;38.2681;0.0732342;2.44025;20.9825 1.15962;143.428;81.7305;79.2355;132.567;41.5978;2.88499;45.5481;39.929;89.4404;106.138;7.6286;125.652;115.437;32.7581;1.28142E-12;105.243;38.8511;31.9156;4.70178;22.3625;102.888;1.73689;19.0606;36.7081 0 Exp 2,14(0.32);Exp 3,1(0.03);Exp 4,4(0.1);Hill,6(0.14);Linear,7(0.16);Poly 2,10(0.23);Power,2(0.05) 1.9559781932278077 90.23456346988678 1.5209722518920898 4.642963409423828 0.771013396381043 1.844538688659668 31.878037013007216 51.67466562335649 21.8151497763348 36.09151464184705 52.68465068623515 96.0422061319467 CONFLICT 0.4318181818181818 0.5681818181818182 0.0 GO:0065009 3 regulation of molecular function 643 686 61 60 52 54 46 46 116 640 1745 0.70317 0.36223 0.64833 6.71 79426;246273;24825;362895;29573;293615;79224;24794;24648;25106;252922;192280;83516;29441;303612;25513;25591;24314;81525;25493;299282;288001;24516;54404;50693;306251;63868;24471;24464;25675;81869;29455;299626;25112;25661;83928;24360;24890;29496;24330;116663;114851;29184;79431;25377;25373 zfp36;trib3;tf;stac3;slc37a4;sirt3;serpind1;serpina3c;serpina1;rgn;pzp;ppp1r3b;ppargc1a;por;polg2;pik3r1;parp1;nqo1;nfkbib;nfkbia;loc299282;kng1;jun;itih4;itih3;itih1;hspd1;hspb1;hp;hmgcr;gstm7;gdf15;gadd45b;gadd45a;fn1;fetub;fabp1;esr1;erbb3;egr1;dusp6;cdkn1a;cd36;bhlhe40;ambp;ahsg ZFP36_10204;TRIB3_10079;TF_10003;STAC3_9953;SLC37A4_9871;SIRT3_9828;SERPIND1_9812;SERPINA3C_32925;SERPINA1_9807;RGN_9699;PZP_9633;PPP1R3B_9545;PPARGC1A_33189;POR_9531;POLG2_9521;PIK3R1_32562;PARP1_9425;NQO1_33055;NFKBIB_9308;NFKBIA_9307;LOC299282_9119;KNG1L1_34113;JUN_8938;ITIH4_32725;ITIH3_32422;ITIH1_33132;HSPD1_8849;HSPB1_8847;HP_8823;HMGCR_8810;GSTM7_8761;GDF15_33113;GADD45B_8679;GADD45A_8678;FN1_8655;FETUB_33027;FABP1_33091;ESR1_33192;ERBB3_8571;EGR1_8533;DUSP6_8506;CDKN1A_8271;CD36_8243;BHLHE40_8141;AMBP_33085;AHSG_8003 43.512376999999994 37.92885 0.348134 31.114260263266402 47.25880588649658 29.817122158910745 29.84063065217391 26.303649999999998 0.118102 21.996426844226733 32.359134017954126 22.149003288233875 69.18423608695652 60.78375 1.15962 46.25669536562918 73.82348273139404 40.475241189293726 33.5 61.695899999999995 0.348134;108.064;45.1539;63.2393;39.7166;2.38018;28.261;29.766;15.797;77.4407;34.1871;36.1411;42.4094;12.4414;63.7758;18.7324;26.9741;87.2765;30.5572;0.520151;45.2017;24.3655;16.4324;57.1163;27.1247;98.1741;42.2579;89.1011;64.9285;1.63089;42.3152;105.149;106.367;102.919;59.5777;32.5155;33.8478;23.3972;60.9984;0.750017;62.3934;6.24967;48.1296;57.8085;17.2343;12.402 0.118102;83.8836;28.132;42.7031;22.6911;0.56209;22.307;23.347;13.013;58.7732;26.3085;27.0588;26.2988;8.48981;40.9553;11.6701;21.799;60.6992;24.2439;0.160202;30.7472;19.538;10.5224;39.6402;21.5108;42.9071;23.9469;60.3265;41.6103;0.663137;31.4035;85.3487;52.7132;89.5012;31.0499;19.6094;26.4736;18.3088;41.6036;0.186019;39.0875;2.44025;37.5433;38.3491;14.1233;10.3013 1.15962;143.428;61.5341;121.52;60.0334;8.82917;38.3264;40.8256;19.9134;89.8047;48.5666;53.6244;81.7305;79.2355;132.567;41.5978;35.2797;197.117;41.2611;2.88499;78.6415;32.1467;39.929;101.869;36.4819;104.278;102.383;106.138;136.455;7.6286;64.5991;125.652;109.434;115.437;105.243;49.9875;46.9257;31.9156;113.972;4.70178;133.304;19.0606;69.1421;110.58;21.9073;15.4235 12 34 12 24825;293615;25106;25591;24314;81525;63868;81869;299626;24360;29496;29184 TF_10003;SIRT3_9828;RGN_9699;PARP1_9425;NQO1_33055;NFKBIB_9308;HSPD1_8849;GSTM7_8761;GADD45B_8679;FABP1_33091;ERBB3_8571;CD36_8243 50.30820666666667 43.73455 28.639336859466347 33.99112416666667 29.76775 17.341851116992007 78.35680583333333 66.8706 49.22809042883627 45.1539;2.38018;77.4407;26.9741;87.2765;30.5572;42.2579;42.3152;106.367;33.8478;60.9984;48.1296 28.132;0.56209;58.7732;21.799;60.6992;24.2439;23.9469;31.4035;52.7132;26.4736;41.6036;37.5433 61.5341;8.82917;89.8047;35.2797;197.117;41.2611;102.383;64.5991;109.434;46.9257;113.972;69.1421 34 79426;246273;362895;29573;79224;24794;24648;252922;192280;83516;29441;303612;25513;25493;299282;288001;24516;54404;50693;306251;24471;24464;25675;29455;25112;25661;83928;24890;24330;116663;114851;79431;25377;25373 ZFP36_10204;TRIB3_10079;STAC3_9953;SLC37A4_9871;SERPIND1_9812;SERPINA3C_32925;SERPINA1_9807;PZP_9633;PPP1R3B_9545;PPARGC1A_33189;POR_9531;POLG2_9521;PIK3R1_32562;NFKBIA_9307;LOC299282_9119;KNG1L1_34113;JUN_8938;ITIH4_32725;ITIH3_32422;ITIH1_33132;HSPB1_8847;HP_8823;HMGCR_8810;GDF15_33113;GADD45A_8678;FN1_8655;FETUB_33027;ESR1_33192;EGR1_8533;DUSP6_8506;CDKN1A_8271;BHLHE40_8141;AMBP_33085;AHSG_8003 41.11384888235294 33.3513 32.00011665786198 28.375750588235295 23.01905 23.474750500417382 65.94685852941177 51.805949999999996 45.48135046714116 0.348134;108.064;63.2393;39.7166;28.261;29.766;15.797;34.1871;36.1411;42.4094;12.4414;63.7758;18.7324;0.520151;45.2017;24.3655;16.4324;57.1163;27.1247;98.1741;89.1011;64.9285;1.63089;105.149;102.919;59.5777;32.5155;23.3972;0.750017;62.3934;6.24967;57.8085;17.2343;12.402 0.118102;83.8836;42.7031;22.6911;22.307;23.347;13.013;26.3085;27.0588;26.2988;8.48981;40.9553;11.6701;0.160202;30.7472;19.538;10.5224;39.6402;21.5108;42.9071;60.3265;41.6103;0.663137;85.3487;89.5012;31.0499;19.6094;18.3088;0.186019;39.0875;2.44025;38.3491;14.1233;10.3013 1.15962;143.428;121.52;60.0334;38.3264;40.8256;19.9134;48.5666;53.6244;81.7305;79.2355;132.567;41.5978;2.88499;78.6415;32.1467;39.929;101.869;36.4819;104.278;106.138;136.455;7.6286;125.652;115.437;105.243;49.9875;31.9156;4.70178;133.304;19.0606;110.58;21.9073;15.4235 0 Exp 2,16(0.35);Exp 3,2(0.05);Exp 4,3(0.07);Hill,3(0.07);Linear,9(0.2);Poly 2,11(0.24);Power,2(0.05) 1.8697040689764215 88.48805868625641 1.5197933912277222 4.21828556060791 0.5376261885346929 1.7350196242332458 34.520784100843976 52.50396989915601 23.483966095605386 36.19729520874243 55.81668789301622 82.55178428089678 DOWN 0.2608695652173913 0.7391304347826086 0.0 GO:0002683 5 negative regulation of immune system process 126 135 12 12 8 8 5 5 157 130 2255 0.12789 0.94049 0.27374 3.7 79426;25513;25493;65164;246186 zfp36;pik3r1;nfkbia;htra1;fgl1 ZFP36_10204;PIK3R1_32562;NFKBIA_9307;HTRA1_8856;FGL1_8640 13.641737000000001 15.4757 0.348134 13.766410352729135 19.139918448512773 12.140320239243227 9.5553408 10.2138 0.118102 10.48966727835641 13.677262751059365 9.786317655899461 24.543182 30.4106 1.15962 21.391801969614903 32.69567868844366 16.373922635141756 0.348134;18.7324;0.520151;33.1323;15.4757 0.118102;11.6701;0.160202;25.6145;10.2138 1.15962;41.5978;2.88499;46.6629;30.4106 0 5 0 5 79426;25513;25493;65164;246186 ZFP36_10204;PIK3R1_32562;NFKBIA_9307;HTRA1_8856;FGL1_8640 13.641737000000001 15.4757 13.766410352729135 9.5553408 10.2138 10.48966727835641 24.543182 30.4106 21.391801969614903 0.348134;18.7324;0.520151;33.1323;15.4757 0.118102;11.6701;0.160202;25.6145;10.2138 1.15962;41.5978;2.88499;46.6629;30.4106 0 Exp 4,1(0.2);Hill,1(0.2);Linear,1(0.2);Poly 2,2(0.4) 1.6996984418528476 8.537994623184204 1.511321783065796 1.9381765127182007 0.1844946743115076 1.6735800504684448 1.5749462928951878 25.70852770710481 0.36074203446202624 18.74993956553798 5.792440840813061 43.293923159186946 DOWN 0.0 1.0 0.0 GO:0032352 6 positive regulation of hormone metabolic process 18 19 5 5 5 5 5 5 157 14 2371 0.99918 0.0054838 0.0054838 26.32 83516;29441;81819;24330;25146 ppargc1a;por;pax8;egr1;cyp17a1 PPARGC1A_33189;POR_9531;PAX8_9432;EGR1_8533;CYP17A1_32365 32.4372234 42.4094 0.750017 24.49071470355016 31.77028988514189 25.50725767563165 23.151245799999998 26.2988 0.186019 18.65026613405539 23.059060602151646 19.823358195459715 65.775496 81.5688 4.70178 34.15725450650388 64.3419127154236 35.239009921494315 0.0 0.750017 0.5 6.5957085 42.4094;12.4414;56.8931;0.750017;49.6922 26.2988;8.48981;45.1162;0.186019;35.6654 81.7305;79.2355;81.5688;4.70178;81.6409 2 3 2 81819;25146 PAX8_9432;CYP17A1_32365 53.292649999999995 53.292649999999995 5.091805220646378 40.3908 40.3908 6.682724767637801 81.60485 81.60485 0.05098239891932644 56.8931;49.6922 45.1162;35.6654 81.5688;81.6409 3 83516;29441;24330 PPARGC1A_33189;POR_9531;EGR1_8533 18.533605666666666 12.4414 21.487491137843342 11.658209666666666 8.48981 13.341604109862141 55.22259333333333 79.2355 43.77008900089345 42.4094;12.4414;0.750017 26.2988;8.48981;0.186019 81.7305;79.2355;4.70178 0 Exp 2,2(0.4);Hill,1(0.2);Linear,1(0.2);Poly 2,1(0.2) 2.1793459747265196 11.619439959526062 1.7521979808807373 4.21828556060791 1.0635976789817903 1.90940523147583 10.970165465280825 53.90428133471916 6.8035667533096635 39.49892484669034 35.835342343488946 95.71564965651106 DOWN 0.4 0.6 0.0 GO:0001523 8 retinoid metabolic process 16 19 4 4 3 3 2 2 160 17 2368 0.88421 0.34304 0.34304 10.53 24856;65210 ttr;cyp2j4 TTR_10102;CYP2J4_32580 32.24005 32.24005 17.8395 20.36545311563188 31.79778136903507 20.355846273764428 21.61885 21.61885 14.6501 9.855300762787506 21.40482626326516 9.850651795958887 43.16475 43.16475 22.6149 29.061876574732747 42.533624520345775 29.048167434501995 0.0 17.8395 0.5 32.24005 46.6406;17.8395 28.5876;14.6501 63.7146;22.6149 2 0 2 24856;65210 TTR_10102;CYP2J4_32580 32.24005 32.24005 20.36545311563188 21.61885 21.61885 9.855300762787506 43.16475 43.16475 29.061876574732747 46.6406;17.8395 28.5876;14.6501 63.7146;22.6149 0 0 Linear,1(0.5);Poly 2,1(0.5) 2.7073585595951277 5.732830047607422 1.9248499870300293 3.8079800605773926 1.3315740448616626 2.866415023803711 4.014972 60.46512799999999 7.960100000000002 35.27759999999999 2.887044000000003 83.44245599999999 UP 1.0 0.0 0.0 GO:0010604 6 positive regulation of macromolecule metabolic process 704 754 52 52 41 43 35 35 127 719 1666 0.011759 0.99293 0.020751 4.64 79426;246273;24825;293615;25106;83516;303612;25513;81819;25591;25493;24539;58954;24516;494344;63868;24471;25675;290556;29455;299626;25112;294515;314322;25661;361969;24890;29496;65030;24330;65210;25423;25695;114851;29184 zfp36;trib3;tf;sirt3;rgn;ppargc1a;polg2;pik3r1;pax8;parp1;nfkbia;lpl;klf6;jun;ier2;hspd1;hspb1;hmgcr;gnl3;gdf15;gadd45b;gadd45a;foxo3;fos;fn1;fga;esr1;erbb3;ephx2;egr1;cyp2j4;ctsc;cebpd;cdkn1a;cd36 ZFP36_10204;TRIB3_10079;TF_10003;SIRT3_9828;RGN_9699;PPARGC1A_33189;POLG2_9521;PIK3R1_32562;PAX8_9432;PARP1_9425;NFKBIA_9307;LPL_32544;KLF6_8969;JUN_8938;IER2_32643;HSPD1_8849;HSPB1_8847;HMGCR_8810;GNL3_8735;GDF15_33113;GADD45B_8679;GADD45A_8678;FOXO3_8662;FOS_8657;FN1_8655;FGA_8632;ESR1_33192;ERBB3_8571;EPHX2_33282;EGR1_8533;CYP2J4_32580;CTSC_32456;CEBPD_8283;CDKN1A_8271;CD36_8243 42.60041080000005 42.2579 1.28141E-12 34.938051719621384 46.6823175121184 32.41676428088645 29.470512405714324 26.2988 1.28141E-12 25.735899628959203 33.18206481058592 25.310550155561582 69.0416528571429 61.5341 1.28142E-12 54.929775266472504 73.09621920960495 46.87439933696421 0.348134;108.064;45.1539;2.38018;77.4407;42.4094;63.7758;18.7324;56.8931;26.9741;0.520151;74.2041;18.9476;16.4324;49.6814;42.2579;89.1011;1.63089;87.6357;105.149;106.367;102.919;13.1992;1.28141E-12;59.5777;28.5803;23.3972;60.9984;38.7293;0.750017;17.8395;56.2386;0.306936;6.24967;48.1296 0.118102;83.8836;28.132;0.56209;58.7732;26.2988;40.9553;11.6701;45.1162;21.799;0.160202;49.8682;11.6941;10.5224;33.4626;23.9469;60.3265;0.663137;54.41;85.3487;52.7132;89.5012;5.6804;1.28141E-12;31.0499;22.529;18.3088;41.6036;29.2097;0.186019;14.6501;38.2681;0.0732342;2.44025;37.5433 1.15962;143.428;61.5341;8.82917;89.8047;81.7305;132.567;41.5978;81.5688;35.2797;2.88499;155.425;45.5481;39.929;89.4404;102.383;106.138;7.6286;238.963;125.652;109.434;115.437;32.7581;1.28142E-12;105.243;38.8511;31.9156;113.972;57.2113;4.70178;22.6149;102.888;1.73689;19.0606;69.1421 13 22 13 24825;293615;25106;81819;25591;24539;63868;290556;299626;29496;65030;65210;29184 TF_10003;SIRT3_9828;RGN_9699;PAX8_9432;PARP1_9425;LPL_32544;HSPD1_8849;GNL3_8735;GADD45B_8679;ERBB3_8571;EPHX2_33282;CYP2J4_32580;CD36_8243 52.69257538461538 48.1296 28.94367253606352 35.25596076923077 37.5433 17.33377762488627 88.16628999999999 81.5688 60.585832762079235 45.1539;2.38018;77.4407;56.8931;26.9741;74.2041;42.2579;87.6357;106.367;60.9984;38.7293;17.8395;48.1296 28.132;0.56209;58.7732;45.1162;21.799;49.8682;23.9469;54.41;52.7132;41.6036;29.2097;14.6501;37.5433 61.5341;8.82917;89.8047;81.5688;35.2797;155.425;102.383;238.963;109.434;113.972;57.2113;22.6149;69.1421 22 79426;246273;83516;303612;25513;25493;58954;24516;494344;24471;25675;29455;25112;294515;314322;25661;361969;24890;24330;25423;25695;114851 ZFP36_10204;TRIB3_10079;PPARGC1A_33189;POLG2_9521;PIK3R1_32562;NFKBIA_9307;KLF6_8969;JUN_8938;IER2_32643;HSPB1_8847;HMGCR_8810;GDF15_33113;GADD45A_8678;FOXO3_8662;FOS_8657;FN1_8655;FGA_8632;ESR1_33192;EGR1_8533;CTSC_32456;CEBPD_8283;CDKN1A_8271 36.63685900000006 21.172400000000003 37.380526692915204 26.05183837272733 15.001450000000002 29.456727080407045 57.74073090909098 40.763400000000004 49.2686505575937 0.348134;108.064;42.4094;63.7758;18.7324;0.520151;18.9476;16.4324;49.6814;89.1011;1.63089;105.149;102.919;13.1992;1.28141E-12;59.5777;28.5803;23.3972;0.750017;56.2386;0.306936;6.24967 0.118102;83.8836;26.2988;40.9553;11.6701;0.160202;11.6941;10.5224;33.4626;60.3265;0.663137;85.3487;89.5012;5.6804;1.28141E-12;31.0499;22.529;18.3088;0.186019;38.2681;0.0732342;2.44025 1.15962;143.428;81.7305;132.567;41.5978;2.88499;45.5481;39.929;89.4404;106.138;7.6286;125.652;115.437;32.7581;1.28142E-12;105.243;38.8511;31.9156;4.70178;102.888;1.73689;19.0606 0 Exp 2,10(0.29);Exp 3,1(0.03);Exp 4,4(0.12);Hill,5(0.15);Linear,4(0.12);Poly 2,9(0.26);Power,2(0.06) 1.90019102786653 69.65269410610199 1.5209722518920898 4.642963409423828 0.746108091619234 1.7576230764389038 31.02541791939695 54.17540368060313 20.944196818007402 37.99682799342125 50.843392612268616 87.23991310201714 DOWN 0.37142857142857144 0.6285714285714286 0.0 GO:0150104 6 transport across blood-brain barrier 5 5 4 4 4 3 3 3 159 2 2383 0.99992 0.0022975 0.0022975 60.0 29184;312382;25303 cd36;abcg2;abcc2 CD36_8243;ABCG2_32656;ABCC2_32541 33.19258 46.2316 5.21654 24.246540197751926 30.953197250011993 25.33714293364536 23.818593333333336 31.1788 2.73368 18.53528777138713 22.73754603232459 19.877948843899585 54.1043 69.1421 11.386 37.53131135452104 48.77382617620259 37.19948350250549 0.0 5.21654 0.0 5.21654 48.1296;5.21654;46.2316 37.5433;2.73368;31.1788 69.1421;11.386;81.7848 2 1 2 29184;312382 CD36_8243;ABCG2_32656 26.673070000000003 26.673070000000003 30.344115727465187 20.13849 20.13849 24.614118352526866 40.26405 40.26405 40.83972996488837 48.1296;5.21654 37.5433;2.73368 69.1421;11.386 1 25303 ABCC2_32541 46.2316 46.2316 31.1788 31.1788 81.7848 81.7848 46.2316 31.1788 81.7848 0 Exp 2,2(0.67);Exp 4,1(0.34) 1.9559483815916001 6.036712884902954 1.5074360370635986 2.6703107357025146 0.5963962687962417 1.8589661121368408 5.755036840225252 60.63012315977475 2.8439407000709522 44.79324596659571 11.633623081398127 96.57497691860188 UP 0.6666666666666666 0.3333333333333333 0.0 GO:1903512 8 phytanic acid metabolic process 1 1 1 1 1 1 1 1 161 0 2385 1.0 0.063604 0.063604 100.0 85255 hacl1 HACL1_8775 17.6275 17.6275 17.6275 17.6275 11.195 11.195 11.195 11.195 37.6534 37.6534 37.6534 37.6534 0.0 17.6275 0.0 17.6275 17.6275 11.195 37.6534 1 0 1 85255 HACL1_8775 17.6275 17.6275 11.195 11.195 37.6534 37.6534 17.6275 11.195 37.6534 0 0 Poly 2,1(1) 1.7180453538894653 1.7180453538894653 1.7180453538894653 1.7180453538894653 0.0 1.7180453538894653 17.6275 17.6275 11.195 11.195 37.6534 37.6534 UP 1.0 0.0 0.0 GO:0015850 6 organic hydroxy compound transport 49 50 12 12 8 11 7 7 155 43 2342 0.98783 0.036408 0.036408 14.0 170698;29500;25428;29184;65054;140668;25303 slco1a2;slc10a2;cyp7a1;cd36;aqp9;abcc3;abcc2 SLCO1A2_9886;SLC10A2_9833;CYP7A1_8430;CD36_8243;AQP9_32709;ABCC3_7941;ABCC2_32541 46.61622571428571 46.2316 5.72128 30.34680999010102 46.52100135043204 18.040391216373752 34.01928185714286 31.1788 0.985273 23.84625506302274 34.361517195097164 13.758410400501253 72.12811428571429 69.1421 22.3625 39.75332306753021 72.8324297415647 29.664404348838577 1.5 32.72455 4.0 48.1296 104.197;56.585;5.72128;48.1296;27.7316;37.7175;46.2316 80.3101;35.2796;0.985273;37.5433;21.9372;30.9007;31.1788 128.412;116.8;22.3625;69.1421;37.4625;48.9329;81.7848 2 5 2 29184;140668 CD36_8243;ABCC3_7941 42.923550000000006 42.923550000000006 7.362466516392382 34.222 34.222 4.697027504709752 59.037499999999994 59.037499999999994 14.290062362355224 48.1296;37.7175 37.5433;30.9007 69.1421;48.9329 5 170698;29500;25428;65054;25303 SLCO1A2_9886;SLC10A2_9833;CYP7A1_8430;AQP9_32709;ABCC2_32541 48.093296 46.2316 36.85507751735275 33.9381946 31.1788 29.110505624246645 77.36436 81.7848 46.89865290307386 104.197;56.585;5.72128;27.7316;46.2316 80.3101;35.2796;0.985273;21.9372;31.1788 128.412;116.8;22.3625;37.4625;81.7848 0 Exp 2,4(0.58);Hill,1(0.15);Linear,1(0.15);Poly 2,1(0.15) 2.2751219947844796 17.12278723716736 1.5806894302368164 4.560328960418701 1.0863284934936233 1.8589661121368408 24.134994265263128 69.09745716330829 16.353728889990407 51.68483482429531 42.678440430688454 101.5777881407401 DOWN 0.2857142857142857 0.7142857142857143 0.0 GO:0009987 2 cellular process 2111 2325 222 219 164 200 147 147 15 2178 207 0.44291 0.66497 0.77347 6.32 257644;79426;24522;312688;286954;296554;24856;308843;246273;171139;24825;360268;362895;170698;29573;25351;65192;361074;29482;29500;293615;246074;297784;25106;501907;293656;308821;29676;192280;298490;83516;298699;29441;303612;85253;24651;363465;25513;360722;81819;25591;294103;24314;81525;25493;24567;100359982;24552;24539;89783;307582;288001;58954;24516;81678;54404;50693;306251;25685;494344;364070;192235;65164;63868;24471;29540;289456;24464;25675;24443;171155;113965;85255;81869;57298;29328;290556;24957;499914;29455;24384;25112;289388;294515;314322;25661;84493;25256;246186;361969;83928;80841;24360;308441;295143;24890;29496;65030;25315;116636;171142;24330;291075;29740;116663;298541;140942;25428;266682;65210;24894;25146;25423;83842;497840;113936;170945;362866;25695;81718;114851;29184;54232;313421;246142;79431;25698;65054;155423;25028;25377;25284;65183;25373;362732;50681;192272;170570;50559;24158;25287;170465;313917;312382;140668;25303;296925 zwint;zfp36;zfp354a;usp18;ugt2b1;tubb4b;ttr;tsku;trib3;timm9;tf;sult1e1;stac3;slco1a2;slc37a4;slc2a2;slc27a2;slc25a30;slc1a2;slc10a2;sirt3;scd;rrs1;rgn;rgd1559459;rgd1307603;rab30;psmb3;ppp1r3b;ppcs;ppargc1a;ppan;por;polg2;plg;pklr;pir;pik3r1;pdia5;pax8;parp1;papss2;nqo1;nfkbib;nfkbia;mt1;mpc2;me1;lpl;laptm5;lama3;kng1;klf6;jun;itpr2;itih4;itih3;itih1;igfbp1;ier2;iars2;hyou1;htra1;hspd1;hspb1;hsd17b7;hsd17b11;hp;hmgcr;hdc;hadhb;hadh;hacl1;gstm7;gstm3l;gpx4;gnl3;glul;gins1;gdf15;gc;gadd45a;g0s2;foxo3;fos;fn1;fmo3;fmo1;fgl1;fga;fetub;fabp7;fabp1;exosc5;etfdh;esr1;erbb3;ephx2;ephx1;eif4ebp1;ehhadh;egr1;eci2;eci1;dusp6;dhdds;ddit4;cyp7a1;cyp3a2;cyp2j4;cyp2a1;cyp17a1;ctsc;crot;cps1;cpb2;chrna2;chpt1;cebpd;cdo1;cdkn1a;cd36;car3;c8b;bmf;bhlhe40;ass1;aqp9;anxa7;ampd1;ambp;amacr;aldh3a2;ahsg;agmo;acox1;acot2;acot12;acot1;acadm;acadl;acaa2;abhd1;abcg2;abcc3;abcc2;aass ZWINT_10214;ZFP36_10204;ZFP354A_10203;USP18_10138;UGT2B10_33303,UGT2B1_33224;TUBB4B_34097;TTR_10102;TSKU_10094;TRIB3_10079;TIMM9_10020;TF_10003;SULT1E1_32446;STAC3_9953;SLCO1A2_9886;SLC37A4_9871;SLC2A2_9863;SLC27A2_9860;SLC25A30_9856;SLC1A2_33059;SLC10A2_9833;SIRT3_9828;SCD1_9787;RRS1_9755;RGN_9699;RGD1559459_9690;RGD1307603_9684;RAB30_9639;PSMB3_9589;PPP1R3B_9545;PPCS_9540;PPARGC1A_33189;PPAN_9534;POR_9531;POLG2_9521;PLG_9501;PKLR_9489;PIR_9487;PIK3R1_32562;PDIA5_9451;PAX8_9432;PARP1_9425;PAPSS2_33237;NQO1_33055;NFKBIB_9308;NFKBIA_9307;MT1A_9255;MPC2_33219;ME1_9215;LPL_32544;LAPTM5_32639;LAMA3_8980;KNG1L1_34113;KLF6_8969;JUN_8938;ITPR2_8931;ITIH4_32725;ITIH3_32422;ITIH1_33132;IGFBP1_32306;IER2_32643;IARS2_8858;HYOU1_8857;HTRA1_8856;HSPD1_8849;HSPB1_8847;HSD17B7_8834;HSD17B11_8832;HP_8823;HMGCR_8810;HDC_8788;HADHB_8777;HADH_8776;HACL1_8775;GSTM7_8761;GSTM3_8760;GPX4_32827;GNL3_8735;GLUL_32832;GINS1_8707;GDF15_33113;GC_32893;GADD45A_8678;G0S2_32729;FOXO3_8662;FOS_8657;FN1_8655;FMO3_8654;FMO1_32787;FGL1_8640;FGA_8632;FETUB_33027;FABP7_8592;FABP1_33091;EXOSC5_32543;ETFDH_8575;ESR1_33192;ERBB3_8571;EPHX2_33282;EPHX1_8567;EIF4EBP1_8550;EHHADH_8534;EGR1_8533;ECI2_8521;ECI1_8520;DUSP6_8506;DHDDS_8467;DDIT4_8450;CYP7A1_8430;CYP3A2_32374;CYP2J4_32580;CYP2A1_32717;CYP17A1_32365;CTSC_32456;CROT_8384;CPS1_32421;CPB2_8369;CHRNA2_32401;CHPT1_33298;CEBPD_8283;CDO1_8275;CDKN1A_8271;CD36_8243;CAR3_8196;C8B_8181;BMF_8152;BHLHE40_8141;ASS1_33159;AQP9_32709;ANXA7_8051;AMPD1_32743;AMBP_33085;AMACR_8038;ALDH3A2_8024;AHSG_8003;AGMO_33265;ACOX1_7973;ACOT2_7969;ACOT12_32718;ACOT1_7968;ACADM_7957;ACADL_32776;ACAA2_7955;ABHD1_7949;ABCG2_32656;ABCC3_7941;ABCC2_32541;AASS_7936 171139(0.04986) 39.39287502721089 33.4878 2.52378E-13 27.93917984138215 41.07091353392272 26.893348516511768 27.564052504761925 25.6145 2.52378E-13 19.17086656188504 28.760063594688457 18.79520056324831 64.26840625850343 48.9329 2.52379E-13 54.479358526798634 65.3716477617963 48.501562400857985 115.5 59.2471 52.0003;0.348134;0.834827;108.883;47.47345;62.7603;46.6406;1.38416;108.064;38.5191;45.1539;50.1846;63.2393;104.197;39.7166;29.7555;7.62189;53.013;13.3235;56.585;2.38018;105.46;60.39;77.4407;2.52378E-13;34.7372;26.4203;23.7888;36.1411;20.3353;42.4094;57.6889;12.4414;63.7758;70.7857;23.0963;50.0307;18.7324;107.066;56.8931;26.9741;34.4443;87.2765;30.5572;0.520151;12.9315;46.8463;80.7944;74.2041;38.674;2.46923;24.3655;18.9476;16.4324;31.8111;57.1163;27.1247;98.1741;49.0259;49.6814;24.7304;40.1982;33.1323;42.2579;89.1011;0.977494;22.4334;64.9285;1.63089;24.5745;31.8029;33.3125;17.6275;42.3152;73.0961;45.9204;87.6357;26.4669;58.9165;105.149;42.356;102.919;46.3784;13.1992;1.28141E-12;59.5777;62.8595;65.2792;15.4757;28.5803;32.5155;24.601;33.8478;41.9329;18.1231;23.3972;60.9984;38.7293;12.4747;83.9001;8.62809;0.750017;10.6467;11.9473;62.3934;47.9438;87.5421;5.72128;12.8505;17.8395;55.3937;49.6922;56.2386;7.4229;31.9826;25.8316;49.3913;16.0559;0.306936;22.9638;6.24967;48.1296;53.9626;21.3618;94.8767;57.8085;26.8037;27.7316;104.64;60.9045;17.2343;2.03774;43.1079;12.402;31.5332;23.1906;8.54905;30.3423;31.2018;11.7137;33.4878;26.5872;17.2895;5.21654;37.7175;46.2316;27.4644 38.9015;0.118102;0.27095;73.1414;34.82915;47.0916;28.5876;0.540568;83.8836;29.55;28.132;36.5009;42.7031;80.3101;22.6911;23.3399;5.49916;37.4804;9.10952;35.2796;0.56209;63.7532;43.109;58.7732;2.52378E-13;26.1766;21.0125;19.2724;27.0588;16.7643;26.2988;41.3659;8.48981;40.9553;46.2356;17.4625;38.7717;11.6701;61.3361;45.1162;21.799;25.719;60.6992;24.2439;0.160202;8.91033;35.8494;59.856;49.8682;24.6273;0.871501;19.538;11.6941;10.5224;24.7342;39.6402;21.5108;42.9071;32.6883;33.4626;19.8021;29.3844;25.6145;23.9469;60.3265;0.322682;18.1233;41.6103;0.663137;21.0619;25.5756;25.7336;11.195;31.4035;51.4219;34.2198;54.41;21.0456;44.7208;85.3487;26.3722;89.5012;33.7914;5.6804;1.28141E-12;31.0499;42.5185;39.7882;10.2138;22.529;19.6094;14.4402;26.4736;31.7336;14.869;18.3088;41.6036;29.2097;7.00435;42.4185;7.31865;0.186019;8.92359;7.15307;39.0875;36.5688;53.2453;0.985273;7.33176;14.6501;38.7444;35.6654;38.2681;5.75707;24.4836;20.4374;41.8524;10.6021;0.0732342;18.5144;2.44025;37.5433;28.5034;17.2088;73.1342;38.3491;20.9825;21.9372;43.9254;50.0633;14.1233;1.165;31.8774;10.3013;24.5474;16.2815;7.19676;24.0157;26.858;8.36151;26.6039;21.3695;14.2242;2.73368;30.9007;31.1788;21.7498 80.8613;1.15962;2.99857;138.144;76.47475;101.528;63.7146;4.10872;143.428;55.4685;61.5341;80.9788;121.52;128.412;60.0334;40.808;13.3925;90.2594;24.6773;116.8;8.82917;422.699;104.942;89.8047;2.52379E-13;50.9085;35.3561;30.901;53.6244;25.6711;81.7305;98.1741;79.2355;132.567;150.579;32.9443;73.0083;41.5978;114.259;81.5688;35.2797;51.1014;197.117;41.2611;2.88499;23.4636;69.127;94.0621;155.425;71.0786;10.4175;32.1467;45.5481;39.929;44.3296;101.869;36.4819;104.278;89.1623;89.4404;32.7087;62.3571;46.6629;102.383;106.138;5.49472;29.2247;136.455;7.6286;29.28;42.1484;46.9856;37.6534;64.5991;140.853;70.4292;238.963;35.4303;91.837;125.652;78.7583;115.437;73.6529;32.7581;1.28142E-12;105.243;120.21;82.9415;30.4106;38.8511;49.9875;35.6155;46.9257;62.1373;23.0103;31.9156;113.972;57.2113;23.684;107.32;10.3909;4.70178;13.0581;19.001;133.304;71.3742;245.492;22.3625;24.0283;22.6149;96.8569;81.6409;102.888;10.316;45.5891;34.8042;62.472;29.905;1.73689;30.0179;19.0606;69.1421;77.0288;27.9161;109.848;110.58;36.7081;37.4625;108.689;82.6625;21.9073;3.73641;66.3058;15.4235;43.8459;33.4539;10.4125;41.1025;37.2719;18.9642;45.3228;35.0407;21.8526;11.386;48.9329;81.7848;37.0295 77 71 76 257644;312688;286954;296554;24856;171139;24825;360268;65192;361074;293615;246074;297784;25106;308821;29676;298490;298699;363465;81819;25591;24314;81525;100359982;24539;364070;63868;289456;24443;171155;113965;85255;81869;57298;29328;290556;499914;289388;25256;80841;24360;308441;295143;29496;65030;25315;116636;171142;291075;29740;298541;266682;65210;24894;25146;83842;170945;362866;29184;246142;155423;25028;25284;65183;362732;50681;192272;170570;50559;24158;25287;170465;313917;312382;140668;296925 ZWINT_10214;USP18_10138;UGT2B10_33303,UGT2B1_33224;TUBB4B_34097;TTR_10102;TIMM9_10020;TF_10003;SULT1E1_32446;SLC27A2_9860;SLC25A30_9856;SIRT3_9828;SCD1_9787;RRS1_9755;RGN_9699;RAB30_9639;PSMB3_9589;PPCS_9540;PPAN_9534;PIR_9487;PAX8_9432;PARP1_9425;NQO1_33055;NFKBIB_9308;MPC2_33219;LPL_32544;IARS2_8858;HSPD1_8849;HSD17B11_8832;HDC_8788;HADHB_8777;HADH_8776;HACL1_8775;GSTM7_8761;GSTM3_8760;GPX4_32827;GNL3_8735;GINS1_8707;G0S2_32729;FMO1_32787;FABP7_8592;FABP1_33091;EXOSC5_32543;ETFDH_8575;ERBB3_8571;EPHX2_33282;EPHX1_8567;EIF4EBP1_8550;EHHADH_8534;ECI2_8521;ECI1_8520;DHDDS_8467;CYP3A2_32374;CYP2J4_32580;CYP2A1_32717;CYP17A1_32365;CROT_8384;CHRNA2_32401;CHPT1_33298;CD36_8243;BMF_8152;ANXA7_8051;AMPD1_32743;AMACR_8038;ALDH3A2_8024;AGMO_33265;ACOX1_7973;ACOT2_7969;ACOT12_32718;ACOT1_7968;ACADM_7957;ACADL_32776;ACAA2_7955;ABHD1_7949;ABCG2_32656;ABCC3_7941;AASS_7936 40.995080789473676 38.6242 25.511682004253352 29.220250526315784 28.3598 16.689452430564973 66.46990828947368 56.3399 59.82791304116504 52.0003;108.883;47.47345;62.7603;46.6406;38.5191;45.1539;50.1846;7.62189;53.013;2.38018;105.46;60.39;77.4407;26.4203;23.7888;20.3353;57.6889;50.0307;56.8931;26.9741;87.2765;30.5572;46.8463;74.2041;24.7304;42.2579;22.4334;24.5745;31.8029;33.3125;17.6275;42.3152;73.0961;45.9204;87.6357;58.9165;46.3784;65.2792;24.601;33.8478;41.9329;18.1231;60.9984;38.7293;12.4747;83.9001;8.62809;10.6467;11.9473;47.9438;12.8505;17.8395;55.3937;49.6922;7.4229;49.3913;16.0559;48.1296;94.8767;104.64;60.9045;2.03774;43.1079;31.5332;23.1906;8.54905;30.3423;31.2018;11.7137;33.4878;26.5872;17.2895;5.21654;37.7175;27.4644 38.9015;73.1414;34.82915;47.0916;28.5876;29.55;28.132;36.5009;5.49916;37.4804;0.56209;63.7532;43.109;58.7732;21.0125;19.2724;16.7643;41.3659;38.7717;45.1162;21.799;60.6992;24.2439;35.8494;49.8682;19.8021;23.9469;18.1233;21.0619;25.5756;25.7336;11.195;31.4035;51.4219;34.2198;54.41;44.7208;33.7914;39.7882;14.4402;26.4736;31.7336;14.869;41.6036;29.2097;7.00435;42.4185;7.31865;8.92359;7.15307;36.5688;7.33176;14.6501;38.7444;35.6654;5.75707;41.8524;10.6021;37.5433;73.1342;43.9254;50.0633;1.165;31.8774;24.5474;16.2815;7.19676;24.0157;26.858;8.36151;26.6039;21.3695;14.2242;2.73368;30.9007;21.7498 80.8613;138.144;76.47475;101.528;63.7146;55.4685;61.5341;80.9788;13.3925;90.2594;8.82917;422.699;104.942;89.8047;35.3561;30.901;25.6711;98.1741;73.0083;81.5688;35.2797;197.117;41.2611;69.127;155.425;32.7087;102.383;29.2247;29.28;42.1484;46.9856;37.6534;64.5991;140.853;70.4292;238.963;91.837;73.6529;82.9415;35.6155;46.9257;62.1373;23.0103;113.972;57.2113;23.684;107.32;10.3909;13.0581;19.001;71.3742;24.0283;22.6149;96.8569;81.6409;10.316;62.472;29.905;69.1421;109.848;108.689;82.6625;3.73641;66.3058;43.8459;33.4539;10.4125;41.1025;37.2719;18.9642;45.3228;35.0407;21.8526;11.386;48.9329;37.0295 71 79426;24522;308843;246273;362895;170698;29573;25351;29482;29500;501907;293656;192280;83516;29441;303612;85253;24651;25513;360722;294103;25493;24567;24552;89783;307582;288001;58954;24516;81678;54404;50693;306251;25685;494344;192235;65164;24471;29540;24464;25675;24957;29455;24384;25112;294515;314322;25661;84493;246186;361969;83928;24890;24330;116663;140942;25428;25423;497840;113936;25695;81718;114851;54232;313421;79431;25698;65054;25377;25373;25303 ZFP36_10204;ZFP354A_10203;TSKU_10094;TRIB3_10079;STAC3_9953;SLCO1A2_9886;SLC37A4_9871;SLC2A2_9863;SLC1A2_33059;SLC10A2_9833;RGD1559459_9690;RGD1307603_9684;PPP1R3B_9545;PPARGC1A_33189;POR_9531;POLG2_9521;PLG_9501;PKLR_9489;PIK3R1_32562;PDIA5_9451;PAPSS2_33237;NFKBIA_9307;MT1A_9255;ME1_9215;LAPTM5_32639;LAMA3_8980;KNG1L1_34113;KLF6_8969;JUN_8938;ITPR2_8931;ITIH4_32725;ITIH3_32422;ITIH1_33132;IGFBP1_32306;IER2_32643;HYOU1_8857;HTRA1_8856;HSPB1_8847;HSD17B7_8834;HP_8823;HMGCR_8810;GLUL_32832;GDF15_33113;GC_32893;GADD45A_8678;FOXO3_8662;FOS_8657;FN1_8655;FMO3_8654;FGL1_8640;FGA_8632;FETUB_33027;ESR1_33192;EGR1_8533;DUSP6_8506;DDIT4_8450;CYP7A1_8430;CTSC_32456;CPS1_32421;CPB2_8369;CEBPD_8283;CDO1_8275;CDKN1A_8271;CAR3_8196;C8B_8181;BHLHE40_8141;ASS1_33159;AQP9_32709;AMBP_33085;AHSG_8003;ABCC2_32541 37.67783787323945 31.8111 30.413788629198795 25.791220819718326 22.6911 21.492948332049206 61.91186887323945 45.5891 48.41959622135382 0.348134;0.834827;1.38416;108.064;63.2393;104.197;39.7166;29.7555;13.3235;56.585;2.52378E-13;34.7372;36.1411;42.4094;12.4414;63.7758;70.7857;23.0963;18.7324;107.066;34.4443;0.520151;12.9315;80.7944;38.674;2.46923;24.3655;18.9476;16.4324;31.8111;57.1163;27.1247;98.1741;49.0259;49.6814;40.1982;33.1323;89.1011;0.977494;64.9285;1.63089;26.4669;105.149;42.356;102.919;13.1992;1.28141E-12;59.5777;62.8595;15.4757;28.5803;32.5155;23.3972;0.750017;62.3934;87.5421;5.72128;56.2386;31.9826;25.8316;0.306936;22.9638;6.24967;53.9626;21.3618;57.8085;26.8037;27.7316;17.2343;12.402;46.2316 0.118102;0.27095;0.540568;83.8836;42.7031;80.3101;22.6911;23.3399;9.10952;35.2796;2.52378E-13;26.1766;27.0588;26.2988;8.48981;40.9553;46.2356;17.4625;11.6701;61.3361;25.719;0.160202;8.91033;59.856;24.6273;0.871501;19.538;11.6941;10.5224;24.7342;39.6402;21.5108;42.9071;32.6883;33.4626;29.3844;25.6145;60.3265;0.322682;41.6103;0.663137;21.0456;85.3487;26.3722;89.5012;5.6804;1.28141E-12;31.0499;42.5185;10.2138;22.529;19.6094;18.3088;0.186019;39.0875;53.2453;0.985273;38.2681;24.4836;20.4374;0.0732342;18.5144;2.44025;28.5034;17.2088;38.3491;20.9825;21.9372;14.1233;10.3013;31.1788 1.15962;2.99857;4.10872;143.428;121.52;128.412;60.0334;40.808;24.6773;116.8;2.52379E-13;50.9085;53.6244;81.7305;79.2355;132.567;150.579;32.9443;41.5978;114.259;51.1014;2.88499;23.4636;94.0621;71.0786;10.4175;32.1467;45.5481;39.929;44.3296;101.869;36.4819;104.278;89.1623;89.4404;62.3571;46.6629;106.138;5.49472;136.455;7.6286;35.4303;125.652;78.7583;115.437;32.7581;1.28142E-12;105.243;120.21;30.4106;38.8511;49.9875;31.9156;4.70178;133.304;245.492;22.3625;102.888;45.5891;34.8042;1.73689;30.0179;19.0606;77.0288;27.9161;110.58;36.7081;37.4625;21.9073;15.4235;81.7848 0 Exp 2,59(0.4);Exp 3,6(0.05);Exp 4,8(0.06);Hill,14(0.1);Linear,33(0.23);Poly 2,25(0.17);Power,3(0.03) 2.160813261279321 714.8283671140671 1.5074360370635986 344.14306640625 28.25580657457847 1.7763590216636658 34.87628098655027 43.9094690678715 24.46492711313314 30.663177896390668 55.46137801150029 73.07543450550646 CONFLICT 0.5170068027210885 0.48299319727891155 0.0 GO:0050727 6 regulation of inflammatory response 108 115 12 11 9 11 9 9 153 106 2279 0.80799 0.30713 0.43888 7.83 79426;312688;25493;24539;63868;29328;24890;25423;25373 zfp36;usp18;nfkbia;lpl;hspd1;gpx4;esr1;ctsc;ahsg ZFP36_10204;USP18_10138;NFKBIA_9307;LPL_32544;HSPD1_8849;GPX4_32827;ESR1_33192;CTSC_32456;AHSG_8003 40.46349833333333 42.2579 0.348134 36.02937616407571 51.094485802569395 30.842368503729197 27.592533777777778 23.9469 0.118102 24.069262670086456 34.36014710980001 20.684546737721547 68.96143444444445 70.4292 1.15962 58.87935716613232 93.99174989860292 54.439811260918184 4.5 44.089150000000004 0.348134;108.883;0.520151;74.2041;42.2579;45.9204;23.3972;56.2386;12.402 0.118102;73.1414;0.160202;49.8682;23.9469;34.2198;18.3088;38.2681;10.3013 1.15962;138.144;2.88499;155.425;102.383;70.4292;31.9156;102.888;15.4235 4 5 4 312688;24539;63868;29328 USP18_10138;LPL_32544;HSPD1_8849;GPX4_32827 67.81635 60.06225 30.87577305423568 45.294075 42.044 21.40667790221469 116.5953 120.2635 37.88311116350755 108.883;74.2041;42.2579;45.9204 73.1414;49.8682;23.9469;34.2198 138.144;155.425;102.383;70.4292 5 79426;25493;24890;25423;25373 ZFP36_10204;NFKBIA_9307;ESR1_33192;CTSC_32456;AHSG_8003 18.581217 12.402 23.11980931008792 13.431300799999999 10.3013 15.841534202870037 30.854342000000003 15.4235 42.10744056633483 0.348134;0.520151;23.3972;56.2386;12.402 0.118102;0.160202;18.3088;38.2681;10.3013 1.15962;2.88499;31.9156;102.888;15.4235 0 Exp 2,5(0.56);Exp 3,1(0.12);Exp 4,1(0.12);Hill,1(0.12);Power,1(0.12) 1.9658216508850317 18.29920780658722 1.547789216041565 3.431420087814331 0.6109003841666698 1.8546061515808105 16.92430590613721 64.00269076052946 11.867282166654626 43.31778538890094 30.49358776257133 107.42928112631756 CONFLICT 0.4444444444444444 0.5555555555555556 0.0 GO:0099183 7 trans-synaptic signaling by BDNF, modulating synaptic transmission 1 1 1 1 1 1 1 1 161 0 2385 1.0 0.063604 0.063604 100.0 85253 plg PLG_9501 70.7857 70.7857 70.7857 70.7857 46.2356 46.2356 46.2356 46.23559999999999 150.579 150.579 150.579 150.579 0.0 70.7857 0.0 70.7857 70.7857 46.2356 150.579 0 1 0 1 85253 PLG_9501 70.7857 70.7857 46.2356 46.2356 150.579 150.579 70.7857 46.2356 150.579 0 Linear,1(1) 1.5254690647125244 1.5254690647125244 1.5254690647125244 1.5254690647125244 0.0 1.5254690647125244 70.7857 70.7857 46.2356 46.2356 150.579 150.579 DOWN 0.0 1.0 0.0 GO:0018958 5 phenol-containing compound metabolic process 27 31 6 6 4 5 3 3 159 28 2357 0.86955 0.31516 0.44393 9.68 24856;24443;25146 ttr;hdc;cyp17a1 TTR_10102;HDC_8788;CYP17A1_32365 40.30243333333333 46.6406 24.5745 13.705983395704699 45.18176887361872 8.645348443344519 28.438299999999998 28.5876 21.0619 7.302894695256125 29.64683329928498 5.1322721140773675 58.211833333333324 63.7146 29.28 26.61064247520781 64.83271807038723 17.419560631594145 0.5 35.60755 46.6406;24.5745;49.6922 28.5876;21.0619;35.6654 63.7146;29.28;81.6409 3 0 3 24856;24443;25146 TTR_10102;HDC_8788;CYP17A1_32365 40.30243333333333 46.6406 13.705983395704699 28.438299999999998 28.5876 7.302894695256125 58.211833333333324 63.7146 26.61064247520781 46.6406;24.5745;49.6922 28.5876;21.0619;35.6654 63.7146;29.28;81.6409 0 0 Exp 2,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 4.007612490679726 21.347320556640625 1.90940523147583 17.513065338134766 9.00432215750702 1.9248499870300293 24.792653055416764 55.8122136112499 20.174296692387564 36.70230330761244 28.099056604447913 88.32461006221875 UP 1.0 0.0 0.0 GO:0009889 5 regulation of biosynthetic process 634 681 58 58 46 49 40 40 122 641 1744 0.3061 0.75591 0.58289 5.87 79426;24522;246273;25357;24825;293615;25106;192280;83516;29441;303612;363465;25513;81819;25591;81525;25493;58954;24516;494344;63868;24471;290556;25112;294515;314322;25661;24890;116636;24330;25428;65210;25146;25695;114851;29184;79431;25698;24158;25287 zfp36;zfp354a;trib3;thrsp;tf;sirt3;rgn;ppp1r3b;ppargc1a;por;polg2;pir;pik3r1;pax8;parp1;nfkbib;nfkbia;klf6;jun;ier2;hspd1;hspb1;gnl3;gadd45a;foxo3;fos;fn1;esr1;eif4ebp1;egr1;cyp7a1;cyp2j4;cyp17a1;cebpd;cdkn1a;cd36;bhlhe40;ass1;acadm;acadl ZFP36_10204;ZFP354A_10203;TRIB3_10079;THRSP_33314;TF_10003;SIRT3_9828;RGN_9699;PPP1R3B_9545;PPARGC1A_33189;POR_9531;POLG2_9521;PIR_9487;PIK3R1_32562;PAX8_9432;PARP1_9425;NFKBIB_9308;NFKBIA_9307;KLF6_8969;JUN_8938;IER2_32643;HSPD1_8849;HSPB1_8847;GNL3_8735;GADD45A_8678;FOXO3_8662;FOS_8657;FN1_8655;ESR1_33192;EIF4EBP1_8550;EGR1_8533;CYP7A1_8430;CYP2J4_32580;CYP17A1_32365;CEBPD_8283;CDKN1A_8271;CD36_8243;BHLHE40_8141;ASS1_33159;ACADM_7957;ACADL_32776 36.26136487500004 31.38125 1.28141E-12 30.441771782096797 38.90163411944119 30.011311013351694 25.19655600500003 24.095399999999998 1.28141E-12 22.456625323561042 27.416897394672702 22.741070415511732 60.62572550000002 46.07745 1.28142E-12 49.38260162266865 60.84204394641822 41.47348426285371 33.5 70.60825 0.348134;0.834827;108.064;32.2053;45.1539;2.38018;77.4407;36.1411;42.4094;12.4414;63.7758;50.0307;18.7324;56.8931;26.9741;30.5572;0.520151;18.9476;16.4324;49.6814;42.2579;89.1011;87.6357;102.919;13.1992;1.28141E-12;59.5777;23.3972;83.9001;0.750017;5.72128;17.8395;49.6922;0.306936;6.24967;48.1296;57.8085;26.8037;11.7137;33.4878 0.118102;0.27095;83.8836;24.3966;28.132;0.56209;58.7732;27.0588;26.2988;8.48981;40.9553;38.7717;11.6701;45.1162;21.799;24.2439;0.160202;11.6941;10.5224;33.4626;23.9469;60.3265;54.41;89.5012;5.6804;1.28141E-12;31.0499;18.3088;42.4185;0.186019;0.985273;14.6501;35.6654;0.0732342;2.44025;37.5433;38.3491;20.9825;8.36151;26.6039 1.15962;2.99857;143.428;46.6068;61.5341;8.82917;89.8047;53.6244;81.7305;79.2355;132.567;73.0083;41.5978;81.5688;35.2797;41.2611;2.88499;45.5481;39.929;89.4404;102.383;106.138;238.963;115.437;32.7581;1.28142E-12;105.243;31.9156;107.32;4.70178;22.3625;22.6149;81.6409;1.73689;19.0606;69.1421;110.58;36.7081;18.9642;45.3228 15 25 15 24825;293615;25106;363465;81819;25591;81525;63868;290556;116636;65210;25146;29184;24158;25287 TF_10003;SIRT3_9828;RGN_9699;PIR_9487;PAX8_9432;PARP1_9425;NFKBIB_9308;HSPD1_8849;GNL3_8735;EIF4EBP1_8550;CYP2J4_32580;CYP17A1_32365;CD36_8243;ACADM_7957;ACADL_32776 44.27242533333334 45.1539 25.227203030712086 30.73318 28.132 16.227902764489574 71.84245133333334 69.1421 55.36522054141504 45.1539;2.38018;77.4407;50.0307;56.8931;26.9741;30.5572;42.2579;87.6357;83.9001;17.8395;49.6922;48.1296;11.7137;33.4878 28.132;0.56209;58.7732;38.7717;45.1162;21.799;24.2439;23.9469;54.41;42.4185;14.6501;35.6654;37.5433;8.36151;26.6039 61.5341;8.82917;89.8047;73.0083;81.5688;35.2797;41.2611;102.383;238.963;107.32;22.6149;81.6409;69.1421;18.9642;45.3228 25 79426;24522;246273;25357;192280;83516;29441;303612;25513;25493;58954;24516;494344;24471;25112;294515;314322;25661;24890;24330;25428;25695;114851;79431;25698 ZFP36_10204;ZFP354A_10203;TRIB3_10079;THRSP_33314;PPP1R3B_9545;PPARGC1A_33189;POR_9531;POLG2_9521;PIK3R1_32562;NFKBIA_9307;KLF6_8969;JUN_8938;IER2_32643;HSPB1_8847;GADD45A_8678;FOXO3_8662;FOS_8657;FN1_8655;ESR1_33192;EGR1_8533;CYP7A1_8430;CEBPD_8283;CDKN1A_8271;BHLHE40_8141;ASS1_33159 31.45472860000005 18.9476 32.718077527026786 21.874581608000053 11.6941 25.203482146842408 53.89569000000005 41.5978 45.26456801288181 0.348134;0.834827;108.064;32.2053;36.1411;42.4094;12.4414;63.7758;18.7324;0.520151;18.9476;16.4324;49.6814;89.1011;102.919;13.1992;1.28141E-12;59.5777;23.3972;0.750017;5.72128;0.306936;6.24967;57.8085;26.8037 0.118102;0.27095;83.8836;24.3966;27.0588;26.2988;8.48981;40.9553;11.6701;0.160202;11.6941;10.5224;33.4626;60.3265;89.5012;5.6804;1.28141E-12;31.0499;18.3088;0.186019;0.985273;0.0732342;2.44025;38.3491;20.9825 1.15962;2.99857;143.428;46.6068;53.6244;81.7305;79.2355;132.567;41.5978;2.88499;45.5481;39.929;89.4404;106.138;115.437;32.7581;1.28142E-12;105.243;31.9156;4.70178;22.3625;1.73689;19.0606;110.58;36.7081 0 Exp 2,15(0.38);Exp 3,2(0.05);Exp 4,3(0.08);Hill,7(0.18);Linear,2(0.05);Poly 2,10(0.25);Power,1(0.03) 1.9917274411402177 83.75343692302704 1.5209722518920898 4.591650485992432 0.8007038227322169 1.844538688659668 26.82736206043809 45.69536768956199 18.237175715820115 32.15593629417995 45.32189870458876 75.92955229541127 DOWN 0.375 0.625 0.0 GO:0006641 7 triglyceride metabolic process 19 21 8 8 5 8 5 5 157 16 2369 0.99853 0.0086526 0.0086526 23.81 29573;246074;24539;497840;29184 slc37a4;scd;lpl;cps1;cd36 SLC37A4_9871;SCD1_9787;LPL_32544;CPS1_32421;CD36_8243 59.898579999999995 48.1296 31.9826 30.02338272583555 56.54368934360731 25.493046579051146 39.667880000000004 37.5433 22.6911 17.374092969620023 38.141956030251144 15.404665692527661 150.57772 69.1421 45.5891 158.05547409911816 123.94483103595893 126.01409664600416 0.5 35.8496 1.5 43.923100000000005 39.7166;105.46;74.2041;31.9826;48.1296 22.6911;63.7532;49.8682;24.4836;37.5433 60.0334;422.699;155.425;45.5891;69.1421 3 2 3 246074;24539;29184 SCD1_9787;LPL_32544;CD36_8243 75.93123333333334 74.2041 28.70419713566871 50.38823333333334 49.8682 13.112686242846392 215.75536666666667 155.425 184.33782911004278 105.46;74.2041;48.1296 63.7532;49.8682;37.5433 422.699;155.425;69.1421 2 29573;497840 SLC37A4_9871;CPS1_32421 35.8496 35.8496 5.468763845696747 23.58735 23.58735 1.2674889052768237 52.81125 52.81125 10.213662479492815 39.7166;31.9826 22.6911;24.4836 60.0334;45.5891 0 Exp 2,4(0.8);Poly 2,1(0.2) 2.0026720111063963 10.18659222126007 1.559399127960205 2.6703107357025146 0.4283695244795798 1.893584966659546 33.58192472173122 86.2152352782688 24.438816052431143 54.89694394756885 12.035988553778509 289.11945144622155 UP 0.6 0.4 0.0 GO:0034248 6 regulation of cellular amide metabolic process 83 90 6 6 5 5 4 4 158 86 2299 0.31087 0.83639 0.65783 4.44 79426;293615;294515;116636 zfp36;sirt3;foxo3;eif4ebp1 ZFP36_10204;SIRT3_9828;FOXO3_8662;EIF4EBP1_8550 24.9569035 7.78969 0.348134 39.6982114858722 37.01453346464647 45.645208241612146 12.194773 3.121245 0.118102 20.30661653726348 18.384048856412225 23.378343510695164 37.5167225 20.793635 1.15962 48.442256376278465 51.13042612517581 55.32410443611921 0.348134;2.38018;13.1992;83.9001 0.118102;0.56209;5.6804;42.4185 1.15962;8.82917;32.7581;107.32 2 2 2 293615;116636 SIRT3_9828;EIF4EBP1_8550 43.140139999999995 43.140139999999995 57.64328823378485 21.490295 21.490295 29.59695134712442 58.074585 58.074585 69.64353377769145 2.38018;83.9001 0.56209;42.4185 8.82917;107.32 2 79426;294515 ZFP36_10204;FOXO3_8662 6.773667 6.773667 9.08707591407588 2.899251 2.899251 3.93313863478037 16.958859999999998 16.958859999999998 22.343499483187497 0.348134;13.1992 0.118102;5.6804 1.15962;32.7581 0 Exp 3,1(0.25);Exp 4,1(0.25);Hill,2(0.5) 1.7695621732399698 7.120342969894409 1.5209722518920898 1.9883413314819336 0.22136076972111565 1.8055146932601929 -13.947343756154758 63.86115075615475 -7.705711206518213 32.09525720651821 -9.956688748752889 84.9901337487529 CONFLICT 0.5 0.5 0.0 GO:0031330 7 negative regulation of cellular catabolic process 57 58 6 6 5 5 4 4 158 54 2331 0.69228 0.50986 0.78448 6.9 79426;25106;24464;246142 zfp36;rgn;hp;bmf ZFP36_10204;RGN_9699;HP_8823;BMF_8152 59.3985085 71.1846 0.348134 41.238130740103756 73.08904888158901 30.484250313818414 43.4089505 50.19175 0.118102 31.60687334534796 53.485508986450085 24.821494299602026 84.31683000000001 99.82634999999999 1.15962 58.63863261434052 103.94864956455311 42.64953157905087 1.5 71.1846 0.348134;77.4407;64.9285;94.8767 0.118102;58.7732;41.6103;73.1342 1.15962;89.8047;136.455;109.848 2 2 2 25106;246142 RGN_9699;BMF_8152 86.15870000000001 86.15870000000001 12.329113836768547 65.9537 65.9537 10.154760484620116 99.82634999999999 99.82634999999999 14.172753347356458 77.4407;94.8767 58.7732;73.1342 89.8047;109.848 2 79426;24464 ZFP36_10204;HP_8823 32.638317 32.638317 45.66521473010915 20.864201 20.864201 29.339414572134906 68.80731 68.80731 95.6682806612108 0.348134;64.9285 0.118102;41.6103 1.15962;136.455 0 Exp 2,1(0.25);Hill,1(0.25);Poly 2,2(0.5) 1.7446112252175596 6.992863774299622 1.6336230039596558 1.9381765127182007 0.13194911834715123 1.7105321288108826 18.98514037469834 99.81187662530166 12.434214621559 74.38368637844101 26.850970037946276 141.78268996205372 CONFLICT 0.5 0.5 0.0 GO:0002192 8 IRES-dependent translational initiation of linear mRNA 1 1 1 1 1 1 1 1 161 0 2385 1.0 0.063604 0.063604 100.0 116636 eif4ebp1 EIF4EBP1_8550 83.9001 83.9001 83.9001 83.9001 42.4185 42.4185 42.4185 42.4185 107.32 107.32 107.32 107.32 0.0 83.9001 0.0 83.9001 83.9001 42.4185 107.32 1 0 1 116636 EIF4EBP1_8550 83.9001 83.9001 42.4185 42.4185 107.32 107.32 83.9001 42.4185 107.32 0 0 Exp 3,1(1) 1.672852873802185 1.672852873802185 1.672852873802185 1.672852873802185 0.0 1.672852873802185 83.9001 83.9001 42.4185 42.4185 107.32 107.32 UP 1.0 0.0 0.0 GO:0007155 3 cell adhesion 145 150 6 6 4 5 4 4 158 146 2239 0.031157 0.98942 0.056989 2.67 307582;25661;361969;29184 lama3;fn1;fga;cd36 LAMA3_8980;FN1_8655;FGA_8632;CD36_8243 34.6892075 38.35495 2.46923 25.003512489386203 42.27645488302654 19.745277101650146 22.99842525 26.789450000000002 0.871501 15.981246968177533 27.936126838894904 11.445845108867552 55.913425000000004 53.9966 10.4175 40.69974175981749 67.0316323457033 36.072266596300864 2.46923;59.5777;28.5803;48.1296 0.871501;31.0499;22.529;37.5433 10.4175;105.243;38.8511;69.1421 1 3 1 29184 CD36_8243 48.1296 48.1296 37.5433 37.5433 69.1421 69.1421 48.1296 37.5433 69.1421 3 307582;25661;361969 LAMA3_8980;FN1_8655;FGA_8632 30.209076666666665 28.5803 28.589054225483455 18.150133666666665 22.529 15.558431615195033 51.50386666666666 38.8511 48.662493162633304 2.46923;59.5777;28.5803 0.871501;31.0499;22.529 10.4175;105.243;38.8511 0 Exp 2,1(0.25);Exp 4,1(0.25);Linear,1(0.25);Power,1(0.25) 1.8758498059363982 7.681657075881958 1.541895866394043 2.6703107357025146 0.5094257255226012 1.7347252368927002 10.185765260401528 59.19264973959848 7.336803221186022 38.660047278813984 16.027678075378844 95.79917192462115 DOWN 0.25 0.75 0.0 GO:0046907 4 intracellular transport 174 183 11 11 10 11 10 10 152 173 2212 0.37335 0.74233 0.75289 5.46 171139;297784;308821;25513;25493;192235;63868;24471;85255;114851 timm9;rrs1;rab30;pik3r1;nfkbia;hyou1;hspd1;hspb1;hacl1;cdkn1a TIMM9_10020;RRS1_9755;RAB30_9639;PIK3R1_32562;NFKBIA_9307;HYOU1_8857;HSPD1_8849;HSPB1_8847;HACL1_8775;CDKN1A_8271 171139(0.04986) 34.001632099999995 32.4697 0.520151 26.47679797127247 36.28635065461273 29.263522801785506 23.279485200000003 22.4797 0.160202 18.551587396749493 24.259458351972167 20.41179957822278 56.784149 48.53315 2.88499 36.894719098760646 60.48338562468341 38.47719788004911 8.5 74.74555000000001 38.5191;60.39;26.4203;18.7324;0.520151;40.1982;42.2579;89.1011;17.6275;6.24967 29.55;43.109;21.0125;11.6701;0.160202;29.3844;23.9469;60.3265;11.195;2.44025 55.4685;104.942;35.3561;41.5978;2.88499;62.3571;102.383;106.138;37.6534;19.0606 5 5 5 171139;297784;308821;63868;85255 TIMM9_10020;RRS1_9755;RAB30_9639;HSPD1_8849;HACL1_8775 37.04296000000001 38.5191 16.311497921343694 25.76268 23.9469 11.761347477521442 67.1606 55.4685 34.23068039865698 38.5191;60.39;26.4203;42.2579;17.6275 29.55;43.109;21.0125;23.9469;11.195 55.4685;104.942;35.3561;102.383;37.6534 5 25513;25493;192235;24471;114851 PIK3R1_32562;NFKBIA_9307;HYOU1_8857;HSPB1_8847;CDKN1A_8271 30.960304200000003 18.7324 35.89021755854586 20.796290399999997 11.6701 24.912209919824676 46.407698 41.5978 40.27194246809458 18.7324;0.520151;40.1982;89.1011;6.24967 11.6701;0.160202;29.3844;60.3265;2.44025 41.5978;2.88499;62.3571;106.138;19.0606 0 Exp 2,3(0.3);Exp 3,1(0.1);Exp 4,2(0.2);Linear,1(0.1);Poly 2,3(0.3) 1.8822754282487795 19.217394590377808 1.522104263305664 2.945132255554199 0.44310054995026854 1.7076814770698547 17.591142699480113 50.41212150051989 11.781092204461167 34.77787819553883 33.916565187097106 79.65173281290289 CONFLICT 0.5 0.5 0.0 GO:0001558 5 regulation of cell growth 111 120 6 6 4 5 4 4 158 116 2269 0.10888 0.95479 0.24594 3.33 25685;25661;114851;25373 igfbp1;fn1;cdkn1a;ahsg IGFBP1_32306;FN1_8655;CDKN1A_8271;AHSG_8003 31.8138175 30.71395 6.24967 26.441339171303174 31.758079777591977 29.209648859557998 19.1199375 20.6756 2.44025 15.082051237998929 17.232533532608695 15.595623731036843 57.22235 54.111450000000005 15.4235 46.65335378015889 58.27577681020067 49.36224456312336 49.0259;59.5777;6.24967;12.402 32.6883;31.0499;2.44025;10.3013 89.1623;105.243;19.0606;15.4235 0 4 0 4 25685;25661;114851;25373 IGFBP1_32306;FN1_8655;CDKN1A_8271;AHSG_8003 31.8138175 30.71395 26.441339171303174 19.1199375 20.6756 15.082051237998929 57.22235 54.111450000000005 46.65335378015889 49.0259;59.5777;6.24967;12.402 32.6883;31.0499;2.44025;10.3013 89.1623;105.243;19.0606;15.4235 0 Exp 2,2(0.5);Exp 4,1(0.25);Power,1(0.25) 2.462393943581285 10.688963770866394 1.522104263305664 3.9562058448791504 1.2034942715133365 2.60532683134079 5.901305112122888 57.726329887877114 4.339527286761049 33.90034771323895 11.502063295444273 102.94263670455572 DOWN 0.0 1.0 0.0 GO:0090031 8 positive regulation of steroid hormone biosynthetic process 6 6 2 2 2 2 2 2 160 4 2381 0.99562 0.050905 0.050905 33.33 29441;25146 por;cyp17a1 POR_9531;CYP17A1_32365 31.0668 31.0668 12.4414 26.340293284623847 24.028034363799282 24.386935169415608 22.077605 22.077605 8.48981 19.216043971745332 16.942611683467742 17.791009898327527 80.4382 80.4382 79.2355 1.7008746514665518 79.98368501344086 1.5747402433374773 0.0 12.4414 0.0 12.4414 12.4414;49.6922 8.48981;35.6654 79.2355;81.6409 1 1 1 25146 CYP17A1_32365 49.6922 49.6922 35.6654 35.6654 81.6409 81.6409 49.6922 35.6654 81.6409 1 29441 POR_9531 12.4414 12.4414 8.48981 8.48981 79.2355 79.2355 12.4414 8.48981 79.2355 0 Linear,1(0.5);Poly 2,1(0.5) 1.9453287387681424 3.8913333415985107 1.90940523147583 1.9819281101226807 0.05128141928235712 1.9456666707992554 -5.438983999999998 67.572584 -4.5544732 48.7096832 78.080908 82.795492 CONFLICT 0.5 0.5 0.0 GO:0033762 6 response to glucagon 17 18 7 7 5 6 4 4 158 14 2371 0.99574 0.02391 0.02391 22.22 497840;81718;25698;25303 cps1;cdo1;ass1;abcc2 CPS1_32421;CDO1_8275;ASS1_33159;ABCC2_32541 31.995425 29.39315 22.9638 10.184843342396904 30.08663119737659 9.23447589011492 23.789824999999997 22.73305 18.5144 5.501195563617685 22.75312399184614 5.079365292046946 48.524975 41.1486 30.0179 23.07224653754306 44.26882675706817 20.564659551508107 0.0 22.9638 0.5 24.88375 31.9826;22.9638;26.8037;46.2316 24.4836;18.5144;20.9825;31.1788 45.5891;30.0179;36.7081;81.7848 0 4 0 4 497840;81718;25698;25303 CPS1_32421;CDO1_8275;ASS1_33159;ABCC2_32541 31.995425 29.39315 10.184843342396904 23.789824999999997 22.73305 5.501195563617685 48.524975 41.1486 23.07224653754306 31.9826;22.9638;26.8037;46.2316 24.4836;18.5144;20.9825;31.1788 45.5891;30.0179;36.7081;81.7848 0 Exp 2,3(0.75);Linear,1(0.25) 1.8927218787410847 7.575843334197998 1.8264755010604858 2.008971929550171 0.07992388013450642 1.8701979517936707 22.014278524451022 41.97657147554897 18.39865334765469 29.18099665234531 25.914173393207818 71.13577660679218 DOWN 0.0 1.0 0.0 GO:0070849 4 response to epidermal growth factor 25 26 3 3 3 2 2 2 160 24 2361 0.7731 0.50003 0.67957 7.69 79426;192272 zfp36;acot2 ZFP36_10204;ACOT2_7969 4.448592 4.448592 0.348134 5.798923315541256 3.183594294569235 5.516074077642339 3.6574310000000003 3.6574310000000003 0.118102 5.0053670735004046 2.565542468581177 4.761224465449418 5.78606 5.78606 1.15962 6.542774193505381 4.3587960250213245 6.223642762776165 0.5 4.448592 0.348134;8.54905 0.118102;7.19676 1.15962;10.4125 1 1 1 192272 ACOT2_7969 8.54905 8.54905 7.19676 7.19676 10.4125 10.4125 8.54905 7.19676 10.4125 1 79426 ZFP36_10204 0.348134 0.348134 0.118102 0.118102 1.15962 1.15962 0.348134 0.118102 1.15962 0 Hill,1(0.5);Linear,1(0.5) 4.789609944491029 13.774231314659119 1.9381765127182007 11.836054801940918 6.998856857668487 6.887115657329559 -3.5883056799999977 12.485489679999997 -3.27965384 10.59451584 -3.281762399999997 14.853882399999996 CONFLICT 0.5 0.5 0.0 GO:0022411 5 cellular component disassembly 46 49 4 4 4 3 3 3 159 46 2339 0.62022 0.6126 1.0 6.12 83516;85253;140942 ppargc1a;plg;ddit4 PPARGC1A_33189;PLG_9501;DDIT4_8450 66.9124 70.7857 42.4094 22.814293589546015 62.63511265458354 19.73183392379275 41.926566666666666 46.2356 26.2988 13.980496835353636 39.912589452332654 12.829797162653023 159.26716666666667 150.579 81.7305 82.22572833720189 137.5985486488255 63.30599599777542 1.5 79.16390000000001 42.4094;70.7857;87.5421 26.2988;46.2356;53.2453 81.7305;150.579;245.492 0 3 0 3 83516;85253;140942 PPARGC1A_33189;PLG_9501;DDIT4_8450 66.9124 70.7857 22.814293589546015 41.926566666666666 46.2356 13.980496835353636 159.26716666666667 150.579 82.22572833720189 42.4094;70.7857;87.5421 26.2988;46.2356;53.2453 81.7305;150.579;245.492 0 Exp 2,1(0.34);Linear,2(0.67) 1.647303875976723 4.950308680534363 1.5254690647125244 1.7576230764389038 0.11701935287132553 1.6672165393829346 41.09559645122074 92.72920354877927 26.106145188526234 57.7469881448071 66.21999574266538 252.31433759066795 DOWN 0.0 1.0 0.0 GO:0043254 6 regulation of protein-containing complex assembly 110 120 5 5 5 5 5 5 157 115 2270 0.21169 0.89112 0.44106 4.17 25591;24890;116636;29184;246142 parp1;esr1;eif4ebp1;cd36;bmf PARP1_9425;ESR1_33192;EIF4EBP1_8550;CD36_8243;BMF_8152 55.45554 48.1296 23.3972 32.6179392139203 61.87705837696336 31.443303030419834 38.64076 37.5433 18.3088 21.807720068429898 43.864216285631194 22.112154060592893 70.70108 69.1421 31.9156 37.532801274445255 78.18133906631763 35.009396667553005 26.9741;23.3972;83.9001;48.1296;94.8767 21.799;18.3088;42.4185;37.5433;73.1342 35.2797;31.9156;107.32;69.1421;109.848 4 1 4 25591;116636;29184;246142 PARP1_9425;EIF4EBP1_8550;CD36_8243;BMF_8152 63.470125 66.01485 31.469818238048862 43.72375 39.980900000000005 21.490857525391284 80.39744999999999 88.23105 35.37632382677245 26.9741;83.9001;48.1296;94.8767 21.799;42.4185;37.5433;73.1342 35.2797;107.32;69.1421;109.848 1 24890 ESR1_33192 23.3972 23.3972 18.3088 18.3088 31.9156 31.9156 23.3972 18.3088 31.9156 0 Exp 2,3(0.6);Exp 3,1(0.2);Poly 2,1(0.2) 2.018349228475187 10.289997220039368 1.672852873802185 2.6703107357025146 0.462704289799866 1.8086696863174438 26.864655687633515 84.04642431236648 19.525450553140118 57.75606944685988 37.802129146025074 103.60003085397494 UP 0.8 0.2 0.0 GO:1901216 7 positive regulation of neuron death 58 61 7 7 7 7 7 7 155 54 2331 0.96309 0.089138 0.10642 11.48 25591;24314;24516;294515;314322;24330;140942 parp1;nqo1;jun;foxo3;fos;egr1;ddit4 PARP1_9425;NQO1_33055;JUN_8938;FOXO3_8662;FOS_8657;EGR1_8533;DDIT4_8450 33.16775957142875 16.4324 1.28141E-12 38.193612132688635 22.413566348922732 28.472238034152934 21.733188428571612 10.5224 1.28141E-12 25.26972281808069 15.481568517997061 18.830039892443764 79.32536857142874 35.2797 1.28142E-12 99.16990234266082 47.6942756863854 74.42110576947874 2.5 14.8158 5.5 87.4093 26.9741;87.2765;16.4324;13.1992;1.28141E-12;0.750017;87.5421 21.799;60.6992;10.5224;5.6804;1.28141E-12;0.186019;53.2453 35.2797;197.117;39.929;32.7581;1.28142E-12;4.70178;245.492 2 5 2 25591;24314 PARP1_9425;NQO1_33055 57.125299999999996 57.125299999999996 42.640235961823684 41.2491 41.2491 27.506595209512938 116.19834999999999 116.19834999999999 114.43625227892167 26.9741;87.2765 21.799;60.6992 35.2797;197.117 5 24516;294515;314322;24330;140942 JUN_8938;FOXO3_8662;FOS_8657;EGR1_8533;DDIT4_8450 23.584743400000256 13.1992 36.49391676050617 13.926823800000255 5.6804 22.40704306293611 64.57617600000026 32.7581 102.59804386763831 16.4324;13.1992;1.28141E-12;0.750017;87.5421 10.5224;5.6804;1.28141E-12;0.186019;53.2453 39.929;32.7581;1.28142E-12;4.70178;245.492 0 Exp 2,2(0.29);Exp 4,1(0.15);Hill,2(0.29);Linear,1(0.15);Poly 2,1(0.15) 2.04514205304111 15.134417653083801 1.576730489730835 4.21828556060791 0.9196676997352992 1.8966681957244873 4.873535746609811 61.46198339624771 3.0131157912423916 40.45326106590083 5.859276811880932 152.79146033097658 DOWN 0.2857142857142857 0.7142857142857143 0.0 GO:0016310 6 phosphorylation 244 262 17 17 11 13 8 8 154 254 2131 0.0097034 0.99614 0.021975 3.05 79426;246273;24825;24651;25513;294103;29496;114851 zfp36;trib3;tf;pklr;pik3r1;papss2;erbb3;cdkn1a ZFP36_10204;TRIB3_10079;TF_10003;PKLR_9489;PIK3R1_32562;PAPSS2_33237;ERBB3_8571;CDKN1A_8271 37.135887999999994 28.7703 0.348134 34.877019494447524 37.00508603380569 33.23277878462978 26.378644 21.59075 0.118102 26.993730227313936 25.65354695524065 25.625250627766693 58.0997275 46.349599999999995 1.15962 48.01002110632788 59.169543107876926 46.31847149066429 0.348134;108.064;45.1539;23.0963;18.7324;34.4443;60.9984;6.24967 0.118102;83.8836;28.132;17.4625;11.6701;25.719;41.6036;2.44025 1.15962;143.428;61.5341;32.9443;41.5978;51.1014;113.972;19.0606 2 6 2 24825;29496 TF_10003;ERBB3_8571 53.07615 53.07615 11.20375339451025 34.8678 34.8678 9.525859713432697 87.75305 87.75305 37.07919468118202 45.1539;60.9984 28.132;41.6036 61.5341;113.972 6 79426;246273;24651;25513;294103;114851 ZFP36_10204;TRIB3_10079;PKLR_9489;PIK3R1_32562;PAPSS2_33237;CDKN1A_8271 31.822467333333332 20.91435 39.272745743694706 23.548925333333333 14.566299999999998 31.040982304802963 48.215286666666664 37.27105 49.82974235153405 0.348134;108.064;23.0963;18.7324;34.4443;6.24967 0.118102;83.8836;17.4625;11.6701;25.719;2.44025 1.15962;143.428;32.9443;41.5978;51.1014;19.0606 0 Exp 2,2(0.25);Exp 4,1(0.13);Hill,1(0.13);Linear,1(0.13);Poly 2,3(0.38) 1.8420836399660752 14.94932758808136 1.522104263305664 2.6967689990997314 0.3635986285335609 1.8201294541358948 12.967346547742736 61.30442945225727 7.672943300611106 45.08434469938889 24.830480240590155 91.36897475940987 DOWN 0.25 0.75 0.0 GO:0071400 7 cellular response to oleic acid 2 2 2 2 2 2 2 2 160 0 2385 1.0 0.0040221 0.0040221 100.0 497840;25698 cps1;ass1 CPS1_32421;ASS1_33159 29.39315 29.39315 26.8037 3.662035309087031 29.405723474883025 3.661992138230002 22.73305 22.73305 20.9825 2.4756515516122723 22.741550066213474 2.475622366749115 41.1486 41.1486 36.7081 6.279815323717738 41.17016153438687 6.279741292479302 0.0 26.8037 0.0 26.8037 31.9826;26.8037 24.4836;20.9825 45.5891;36.7081 0 2 0 2 497840;25698 CPS1_32421;ASS1_33159 29.39315 29.39315 3.662035309087031 22.73305 22.73305 2.4756515516122723 41.1486 41.1486 6.279815323717738 31.9826;26.8037 24.4836;20.9825 45.5891;36.7081 0 Exp 2,2(1) 1.8537490178148923 3.7079052925109863 1.8264755010604858 1.8814297914505005 0.03885855139007408 1.8539526462554932 24.317828 34.468472 19.301972 26.164127999999998 32.445220000000006 49.85198 DOWN 0.0 1.0 0.0 GO:0042593 7 glucose homeostasis 85 91 10 10 9 9 8 8 154 83 2302 0.87932 0.21883 0.3761 8.79 29573;83516;25513;294515;25661;25428;113936;29184 slc37a4;ppargc1a;pik3r1;foxo3;fn1;cyp7a1;cpb2;cd36 SLC37A4_9871;PPARGC1A_33189;PIK3R1_32562;FOXO3_8662;FN1_8655;CYP7A1_8430;CPB2_8369;CD36_8243 31.6647225 32.774100000000004 5.72128 18.692303011638426 42.73236441347447 15.580486245905094 19.544534125 21.56425 0.985273 12.599967755390786 26.332591876703983 10.246543076338579 55.95895 50.8156 22.3625 28.2950120055007 71.98380087832864 25.675101676784617 3.5 32.774100000000004 39.7166;42.4094;18.7324;13.1992;59.5777;5.72128;25.8316;48.1296 22.6911;26.2988;11.6701;5.6804;31.0499;0.985273;20.4374;37.5433 60.0334;81.7305;41.5978;32.7581;105.243;22.3625;34.8042;69.1421 1 7 1 29184 CD36_8243 48.1296 48.1296 37.5433 37.5433 69.1421 69.1421 48.1296 37.5433 69.1421 7 29573;83516;25513;294515;25661;25428;113936 SLC37A4_9871;PPARGC1A_33189;PIK3R1_32562;FOXO3_8662;FN1_8655;CYP7A1_8430;CPB2_8369 29.31259714285714 25.8316 18.86794325565783 16.973281857142858 20.4374 11.113650551314697 54.07564285714286 41.5978 30.015636386882143 39.7166;42.4094;18.7324;13.1992;59.5777;5.72128;25.8316 22.6911;26.2988;11.6701;5.6804;31.0499;0.985273;20.4374 60.0334;81.7305;41.5978;32.7581;105.243;22.3625;34.8042 0 Exp 2,3(0.38);Exp 4,1(0.13);Hill,1(0.13);Poly 2,2(0.25);Power,1(0.13) 2.0978054424297192 17.886088252067566 1.5630855560302734 4.560328960418701 0.9983073848375417 1.8364092707633972 18.711617368787206 44.61782763121279 10.81320193528271 28.275866314717295 36.35150703441256 75.56639296558743 DOWN 0.125 0.875 0.0 GO:1901863 6 positive regulation of muscle tissue development 31 33 3 3 3 3 3 3 159 30 2355 0.8458 0.35094 0.46366 9.09 83516;25675;29496 ppargc1a;hmgcr;erbb3 PPARGC1A_33189;HMGCR_8810;ERBB3_8571 35.01289666666667 42.4094 1.63089 30.367029934948082 47.767677306371006 20.62981013605717 22.855179000000003 26.2988 0.663137 20.686330555642847 31.40829571064959 14.71537756430842 67.77703333333334 81.7305 7.6286 54.52755363028249 90.72748497813865 36.78137699200963 0.5 22.020145 42.4094;1.63089;60.9984 26.2988;0.663137;41.6036 81.7305;7.6286;113.972 1 2 1 29496 ERBB3_8571 60.9984 60.9984 41.6036 41.6036 113.972 113.972 60.9984 41.6036 113.972 2 83516;25675 PPARGC1A_33189;HMGCR_8810 22.020145 22.020145 28.834760947683435 13.4809685 13.4809685 18.12715114751307 44.679550000000006 44.679550000000006 52.39795598880743 42.4094;1.63089 26.2988;0.663137 81.7305;7.6286 0 Exp 2,1(0.34);Exp 4,1(0.34);Linear,1(0.34) 1.7492520567286092 5.260695815086365 1.6013026237487793 1.9017701148986816 0.15027484035586638 1.7576230764389038 0.6493673681005276 69.3764259652328 -0.5536076890981221 46.26396568909812 6.073297710610447 129.48076895605624 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0006873 6 cellular ion homeostasis 143 151 19 19 15 14 11 11 151 140 2245 0.75089 0.36403 0.60542 7.28 24825;29573;25106;24567;288001;81678;81869;24890;29184;155423;25303 tf;slc37a4;rgn;mt1;kng1;itpr2;gstm7;esr1;cd36;anxa7;abcc2 TF_10003;SLC37A4_9871;RGN_9699;MT1A_9255;KNG1L1_34113;ITPR2_8931;GSTM7_8761;ESR1_33192;CD36_8243;ANXA7_8051;ABCC2_32541 45.102990909090906 42.3152 12.9315 25.981664030945172 48.99295011819905 23.48848443992133 29.558057272727275 28.132 8.91033 13.621585766212462 32.03323298222502 12.219872079842245 60.676609090909096 61.5341 23.4636 26.42077718881314 65.81752066047099 21.99498059009341 6.5 45.692750000000004 45.1539;39.7166;77.4407;12.9315;24.3655;31.8111;42.3152;23.3972;48.1296;104.64;46.2316 28.132;22.6911;58.7732;8.91033;19.538;24.7342;31.4035;18.3088;37.5433;43.9254;31.1788 61.5341;60.0334;89.8047;23.4636;32.1467;44.3296;64.5991;31.9156;69.1421;108.689;81.7848 5 6 5 24825;25106;81869;29184;155423 TF_10003;RGN_9699;GSTM7_8761;CD36_8243;ANXA7_8051 63.53588 48.1296 26.965072835188135 39.95548 37.5433 12.130710040925067 78.7538 69.1421 20.046801284244825 45.1539;77.4407;42.3152;48.1296;104.64 28.132;58.7732;31.4035;37.5433;43.9254 61.5341;89.8047;64.5991;69.1421;108.689 6 29573;24567;288001;81678;24890;25303 SLC37A4_9871;MT1A_9255;KNG1L1_34113;ITPR2_8931;ESR1_33192;ABCC2_32541 29.742250000000002 28.0883 12.061814766402263 20.893538333333332 21.11455 7.42811087585644 45.61228333333333 38.238150000000005 21.80619217877497 39.7166;12.9315;24.3655;31.8111;23.3972;46.2316 22.6911;8.91033;19.538;24.7342;18.3088;31.1788 60.0334;23.4636;32.1467;44.3296;31.9156;81.7848 0 Exp 2,3(0.28);Exp 3,1(0.1);Linear,3(0.28);Poly 2,4(0.37) 1.9731278976319127 22.03183078765869 1.5461770296096802 2.6703107357025146 0.37089712751990217 1.8589661121368408 29.74880865466845 60.457173163513374 21.508214499009267 37.60790004644528 45.062927543131515 76.29029063868666 CONFLICT 0.45454545454545453 0.5454545454545454 0.0 GO:0050678 6 regulation of epithelial cell proliferation 113 121 14 14 10 11 8 8 154 113 2272 0.63766 0.50948 0.84864 6.61 79426;24794;25106;24516;65164;24957;24890;113936 zfp36;serpina3c;rgn;jun;htra1;glul;esr1;cpb2 ZFP36_10204;SERPINA3C_32925;RGN_9699;JUN_8938;HTRA1_8856;GLUL_32832;ESR1_33192;CPB2_8369 29.101904249999997 26.149250000000002 0.348134 22.00909460402551 34.228445024864186 23.683773154088527 22.27087525 20.741500000000002 0.118102 16.8780947963579 26.135430279356456 18.116084964859304 40.06649 37.67965 1.15962 24.340926162487268 46.335685597576266 25.068516699864883 5.5 31.44915 0.348134;29.766;77.4407;16.4324;33.1323;26.4669;23.3972;25.8316 0.118102;23.347;58.7732;10.5224;25.6145;21.0456;18.3088;20.4374 1.15962;40.8256;89.8047;39.929;46.6629;35.4303;31.9156;34.8042 1 7 1 25106 RGN_9699 77.4407 77.4407 58.7732 58.7732 89.8047 89.8047 77.4407 58.7732 89.8047 7 79426;24794;24516;65164;24957;24890;113936 ZFP36_10204;SERPINA3C_32925;JUN_8938;HTRA1_8856;GLUL_32832;ESR1_33192;CPB2_8369 22.196361999999997 25.8316 10.957166194601053 17.056257428571428 20.4374 8.863080750737094 32.96103142857143 35.4303 14.832748006564648 0.348134;29.766;16.4324;33.1323;26.4669;23.3972;25.8316 0.118102;23.347;10.5224;25.6145;21.0456;18.3088;20.4374 1.15962;40.8256;39.929;46.6629;35.4303;31.9156;34.8042 0 Exp 2,2(0.25);Hill,1(0.13);Linear,3(0.38);Poly 2,2(0.25) 1.8707772337179016 15.179424166679382 1.5603101253509521 2.436986207962036 0.3483096233764513 1.829031527042389 13.850379808562973 44.35342869143703 10.57495227166624 33.966798228333765 23.19908872914133 56.93389127085869 DOWN 0.125 0.875 0.0 GO:0051591 5 response to cAMP 57 59 18 18 13 17 12 12 150 47 2338 0.99995 2.372E-4 2.372E-4 20.34 24825;24651;25513;24516;81678;314322;24330;25146;497840;81718;25698;65054 tf;pklr;pik3r1;jun;itpr2;fos;egr1;cyp17a1;cps1;cdo1;ass1;aqp9 TF_10003;PKLR_9489;PIK3R1_32562;JUN_8938;ITPR2_8931;FOS_8657;EGR1_8533;CYP17A1_32365;CPS1_32421;CDO1_8275;ASS1_33159;AQP9_32709 24.595834750000105 24.95 1.28141E-12 14.934114177183044 25.49291272863246 14.281053793633028 17.857526583333442 19.74845 1.28141E-12 10.720147277672309 18.53014105044582 10.035250769500884 38.037923333333445 38.695750000000004 1.28142E-12 21.777159903748537 38.06475857732958 19.84418718718763 1.5 8.5912085 4.5 23.03005 45.1539;23.0963;18.7324;16.4324;31.8111;1.28141E-12;0.750017;49.6922;31.9826;22.9638;26.8037;27.7316 28.132;17.4625;11.6701;10.5224;24.7342;1.28141E-12;0.186019;35.6654;24.4836;18.5144;20.9825;21.9372 61.5341;32.9443;41.5978;39.929;44.3296;1.28142E-12;4.70178;81.6409;45.5891;30.0179;36.7081;37.4625 2 10 2 24825;25146 TF_10003;CYP17A1_32365 47.42305 47.42305 3.209062705058905 31.898699999999998 31.898699999999998 5.326918225390748 71.5875 71.5875 14.21765462796167 45.1539;49.6922 28.132;35.6654 61.5341;81.6409 10 24651;25513;24516;81678;314322;24330;497840;81718;25698;65054 PKLR_9489;PIK3R1_32562;JUN_8938;ITPR2_8931;FOS_8657;EGR1_8533;CPS1_32421;CDO1_8275;ASS1_33159;AQP9_32709 20.030391700000127 23.03005 11.51043551071012 15.049291900000128 17.98845 9.205011643569598 31.328008000000136 37.085300000000004 16.031815930474956 23.0963;18.7324;16.4324;31.8111;1.28141E-12;0.750017;31.9826;22.9638;26.8037;27.7316 17.4625;11.6701;10.5224;24.7342;1.28141E-12;0.186019;24.4836;18.5144;20.9825;21.9372 32.9443;41.5978;39.929;44.3296;1.28142E-12;4.70178;45.5891;30.0179;36.7081;37.4625 0 Exp 2,3(0.25);Hill,2(0.17);Linear,4(0.34);Poly 2,3(0.25) 2.04130274744497 25.40918207168579 1.6674995422363281 4.21828556060791 0.7123803487493021 1.889048993587494 16.146064206500974 33.045605293499236 11.792032265147231 23.923020901519653 25.716335183370987 50.359511483295904 DOWN 0.16666666666666666 0.8333333333333334 0.0 GO:0035026 6 leading edge cell differentiation 2 2 1 1 1 1 1 1 161 1 2384 0.99598 0.12319 0.12319 50.0 24516 jun JUN_8938 16.4324 16.4324 16.4324 16.4324 10.5224 10.5224 10.5224 10.5224 39.929 39.929 39.929 39.929 0.0 16.4324 0.0 16.4324 16.4324 10.5224 39.929 0 1 0 1 24516 JUN_8938 16.4324 16.4324 10.5224 10.5224 39.929 39.929 16.4324 10.5224 39.929 0 Poly 2,1(1) 1.9785058498382568 1.9785058498382568 1.9785058498382568 1.9785058498382568 0.0 1.9785058498382568 16.4324 16.4324 10.5224 10.5224 39.929 39.929 DOWN 0.0 1.0 0.0 GO:0071479 6 cellular response to ionizing radiation 24 24 3 3 3 3 3 3 159 21 2364 0.93819 0.19305 0.19305 12.5 25112;24330;114851 gadd45a;egr1;cdkn1a GADD45A_8678;EGR1_8533;CDKN1A_8271 36.63956233333333 6.24967 0.750017 57.465506513362136 40.287627465148944 58.46448755130201 30.70915633333333 2.44025 0.186019 50.92787731908498 33.800529236582236 51.95316477893842 46.39979333333333 19.0606 4.70178 60.21748795989528 50.67514905011775 60.78328539639796 0.5 3.4998435 1.5 54.584334999999996 102.919;0.750017;6.24967 89.5012;0.186019;2.44025 115.437;4.70178;19.0606 0 3 0 3 25112;24330;114851 GADD45A_8678;EGR1_8533;CDKN1A_8271 36.63956233333333 6.24967 57.465506513362136 30.70915633333333 2.44025 50.92787731908498 46.39979333333333 19.0606 60.21748795989528 102.919;0.750017;6.24967 89.5012;0.186019;2.44025 115.437;4.70178;19.0606 0 Exp 4,1(0.34);Hill,1(0.34);Poly 2,1(0.34) 2.189143547085892 7.374353289604187 1.522104263305664 4.21828556060791 1.5253757329129518 1.6339634656906128 -28.388779949698005 101.66790461636467 -26.92116207834937 88.33947474501603 -21.742709118461107 114.54229578512778 DOWN 0.0 1.0 0.0 GO:0010332 6 response to gamma radiation 40 40 4 4 4 3 3 3 159 37 2348 0.75238 0.473 0.73888 7.5 25591;24330;114851 parp1;egr1;cdkn1a PARP1_9425;EGR1_8533;CDKN1A_8271 11.324595666666667 6.24967 0.750017 13.82901967564463 11.690597633133784 13.5687637224449 8.141756333333333 2.44025 0.186019 11.881103390610246 8.313925894195732 11.784256728421665 19.680693333333334 19.0606 4.70178 15.298388303613338 20.559021306611136 14.623566013435106 1.0 6.24967 26.9741;0.750017;6.24967 21.799;0.186019;2.44025 35.2797;4.70178;19.0606 1 2 1 25591 PARP1_9425 26.9741 26.9741 21.799 21.799 35.2797 35.2797 26.9741 21.799 35.2797 2 24330;114851 EGR1_8533;CDKN1A_8271 3.4998435 3.4998435 3.8888419304729402 1.3131344999999999 1.3131344999999999 1.5939820264609321 11.88119 11.88119 10.153218991837024 0.750017;6.24967 0.186019;2.44025 4.70178;19.0606 0 Exp 2,1(0.34);Exp 4,1(0.34);Hill,1(0.34) 2.2645393909783884 7.549059510231018 1.522104263305664 4.21828556060791 1.480864724365517 1.8086696863174438 -4.324413268762969 26.9736046020963 -5.3029778187103265 21.58649048537699 2.3689372670265136 36.99244939964015 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0051049 5 regulation of transport 454 483 47 46 36 39 30 30 132 453 1932 0.48925 0.59292 1.0 6.21 246273;24825;362895;170698;29482;293615;25106;83516;25513;81819;25591;25493;100359982;24539;63868;25675;113965;81869;24957;25661;361969;24890;29496;65210;113936;29184;25373;170465;312382;25303 trib3;tf;stac3;slco1a2;slc1a2;sirt3;rgn;ppargc1a;pik3r1;pax8;parp1;nfkbia;mpc2;lpl;hspd1;hmgcr;hadh;gstm7;glul;fn1;fga;esr1;erbb3;cyp2j4;cpb2;cd36;ahsg;acaa2;abcg2;abcc2 TRIB3_10079;TF_10003;STAC3_9953;SLCO1A2_9886;SLC1A2_33059;SIRT3_9828;RGN_9699;PPARGC1A_33189;PIK3R1_32562;PAX8_9432;PARP1_9425;NFKBIA_9307;MPC2_33219;LPL_32544;HSPD1_8849;HMGCR_8810;HADH_8776;GSTM7_8761;GLUL_32832;FN1_8655;FGA_8632;ESR1_33192;ERBB3_8571;CYP2J4_32580;CPB2_8369;CD36_8243;AHSG_8003;ACAA2_7955;ABCG2_32656;ABCC2_32541 39.37177203333333 37.7852 0.520151 27.801670234653315 40.76210854491201 24.086421461681432 28.291120966666664 24.840249999999997 0.160202 20.78189999521756 28.834250139294063 17.456905596809765 62.10078533333333 54.25985 2.88499 42.94393281827966 65.97205989759578 41.740044728127764 23.5 60.28805 108.064;45.1539;63.2393;104.197;13.3235;2.38018;77.4407;42.4094;18.7324;56.8931;26.9741;0.520151;46.8463;74.2041;42.2579;1.63089;33.3125;42.3152;26.4669;59.5777;28.5803;23.3972;60.9984;17.8395;25.8316;48.1296;12.402;26.5872;5.21654;46.2316 83.8836;28.132;42.7031;80.3101;9.10952;0.56209;58.7732;26.2988;11.6701;45.1162;21.799;0.160202;35.8494;49.8682;23.9469;0.663137;25.7336;31.4035;21.0456;31.0499;22.529;18.3088;41.6036;14.6501;20.4374;37.5433;10.3013;21.3695;2.73368;31.1788 143.428;61.5341;121.52;128.412;24.6773;8.82917;89.8047;81.7305;41.5978;81.5688;35.2797;2.88499;69.127;155.425;102.383;7.6286;46.9856;64.5991;35.4303;105.243;38.8511;31.9156;113.972;22.6149;34.8042;69.1421;15.4235;35.0407;11.386;81.7848 15 15 15 24825;293615;25106;81819;25591;100359982;24539;63868;113965;81869;29496;65210;29184;170465;312382 TF_10003;SIRT3_9828;RGN_9699;PAX8_9432;PARP1_9425;MPC2_33219;LPL_32544;HSPD1_8849;HADH_8776;GSTM7_8761;ERBB3_8571;CYP2J4_32580;CD36_8243;ACAA2_7955;ABCG2_32656 40.436614666666664 42.3152 22.289791744247236 29.27228466666667 28.132 16.293434904071397 64.51279133333334 64.5991 40.387869847204094 45.1539;2.38018;77.4407;56.8931;26.9741;46.8463;74.2041;42.2579;33.3125;42.3152;60.9984;17.8395;48.1296;26.5872;5.21654 28.132;0.56209;58.7732;45.1162;21.799;35.8494;49.8682;23.9469;25.7336;31.4035;41.6036;14.6501;37.5433;21.3695;2.73368 61.5341;8.82917;89.8047;81.5688;35.2797;69.127;155.425;102.383;46.9856;64.5991;113.972;22.6149;69.1421;35.0407;11.386 15 246273;362895;170698;29482;83516;25513;25493;25675;24957;25661;361969;24890;113936;25373;25303 TRIB3_10079;STAC3_9953;SLCO1A2_9886;SLC1A2_33059;PPARGC1A_33189;PIK3R1_32562;NFKBIA_9307;HMGCR_8810;GLUL_32832;FN1_8655;FGA_8632;ESR1_33192;CPB2_8369;AHSG_8003;ABCC2_32541 38.306929399999994 26.4669 33.19353320002485 27.309957266666668 21.0456 25.041663704307126 59.688779333333336 38.8511 46.65236633998298 108.064;63.2393;104.197;13.3235;42.4094;18.7324;0.520151;1.63089;26.4669;59.5777;28.5803;23.3972;25.8316;12.402;46.2316 83.8836;42.7031;80.3101;9.10952;26.2988;11.6701;0.160202;0.663137;21.0456;31.0499;22.529;18.3088;20.4374;10.3013;31.1788 143.428;121.52;128.412;24.6773;81.7305;41.5978;2.88499;7.6286;35.4303;105.243;38.8511;31.9156;34.8042;15.4235;81.7848 0 Exp 2,11(0.37);Exp 3,1(0.04);Exp 4,3(0.1);Hill,1(0.04);Linear,7(0.24);Poly 2,6(0.2);Power,1(0.04) 1.9564874211560526 60.62320077419281 1.5074360370635986 3.8079800605773926 0.578535236896789 1.8215704560279846 29.423072109758152 49.32047195690852 20.854413562071183 35.727828371262135 46.73349633446201 77.46807433220468 CONFLICT 0.5 0.5 0.0 GO:0071236 5 cellular response to antibiotic 73 82 10 10 10 8 8 8 154 74 2311 0.92698 0.14665 0.24292 9.76 286954;24314;58954;81678;24471;24360;24330;25146 ugt2b1;nqo1;klf6;itpr2;hspb1;fabp1;egr1;cyp17a1 UGT2B10_33303,UGT2B1_33224;NQO1_33055;KLF6_8969;ITPR2_8931;HSPB1_8847;FABP1_33091;EGR1_8533;CYP17A1_32365 44.862470875 40.660624999999996 0.750017 30.926872375310026 41.430003713459556 29.36290143436196 31.826021125 30.651375 0.186019 21.23011233756461 29.66504407434821 19.999251973638255 75.35947875 61.700225 4.70178 57.89827690382912 61.602587424229824 40.75741946934797 3.5 40.660624999999996 47.47345;87.2765;18.9476;31.8111;89.1011;33.8478;0.750017;49.6922 34.82915;60.6992;11.6941;24.7342;60.3265;26.4736;0.186019;35.6654 76.47475;197.117;45.5481;44.3296;106.138;46.9257;4.70178;81.6409 5 4 4 286954;24314;24360;25146 UGT2B10_33303,UGT2B1_33224;NQO1_33055;FABP1_33091;CYP17A1_32365 54.572487499999994 48.582825 22.90035403716048 39.4168375 35.247275 14.782720887090605 100.53958750000001 79.05782500000001 66.17633597992025 47.47345;87.2765;33.8478;49.6922 34.82915;60.6992;26.4736;35.6654 76.47475;197.117;46.9257;81.6409 4 58954;81678;24471;24330 KLF6_8969;ITPR2_8931;HSPB1_8847;EGR1_8533 35.152454250000005 25.379350000000002 38.1564586777779 24.23520475 18.21415 26.067049651943545 50.17937 44.93885 41.853904376018896 18.9476;31.8111;89.1011;0.750017 11.6941;24.7342;60.3265;0.186019 45.5481;44.3296;106.138;4.70178 0 Exp 2,4(0.45);Hill,1(0.12);Linear,2(0.23);Poly 2,2(0.23) 1.8907953655260543 17.933629274368286 1.5740432739257812 4.21828556060791 0.8430976118767697 1.6973176002502441 23.43124172107683 66.29370002892318 17.11430385374076 46.53773839625923 35.238019816640275 115.48093768335974 CONFLICT 0.5 0.5 0.0 GO:1901565 5 organonitrogen compound catabolic process 128 143 9 9 7 7 6 6 156 137 2248 0.18155 0.90424 0.3758 4.2 29676;24443;81718;25377;25287;296925 psmb3;hdc;cdo1;ambp;acadl;aass PSMB3_9589;HDC_8788;CDO1_8275;AMBP_33085;ACADL_32776;AASS_7936 24.91893333333333 24.181649999999998 17.2343 5.369857502640715 24.988309731600275 4.486731697857215 20.22095 20.16715 14.1233 4.117767003000539 20.09592853646185 3.410386530499824 32.409749999999995 30.45945 21.9073 7.952144546158612 32.90578451637407 6.642094376917136 23.7888;24.5745;22.9638;17.2343;33.4878;27.4644 19.2724;21.0619;18.5144;14.1233;26.6039;21.7498 30.901;29.28;30.0179;21.9073;45.3228;37.0295 4 2 4 29676;24443;25287;296925 PSMB3_9589;HDC_8788;ACADL_32776;AASS_7936 27.328874999999996 26.01945 4.399599861635177 22.172 21.40585 3.1336875306896874 35.633325 33.96525 7.270829133542262 23.7888;24.5745;33.4878;27.4644 19.2724;21.0619;26.6039;21.7498 30.901;29.28;45.3228;37.0295 2 81718;25377 CDO1_8275;AMBP_33085 20.09905 20.09905 4.051368302808345 16.318849999999998 16.318849999999998 3.10497658686825 25.962600000000002 25.962600000000002 5.73506025949161 22.9638;17.2343 18.5144;14.1233 30.0179;21.9073 0 Exp 2,4(0.67);Linear,2(0.34) 2.645030899048799 26.608481287956238 1.6278724670410156 17.513065338134766 6.40892142156593 1.908018708229065 20.6221524481776 29.21571421848906 16.926050174573195 23.51584982542681 26.046709143678072 38.77279085632193 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0010648 6 negative regulation of cell communication 320 334 32 32 25 30 23 23 139 311 2074 0.71251 0.37242 0.63187 6.89 308843;293615;25591;25493;192235;65164;24471;25675;113965;81869;29455;294515;25661;361969;24890;29496;24330;116663;140942;65210;246142;25373;170465 tsku;sirt3;parp1;nfkbia;hyou1;htra1;hspb1;hmgcr;hadh;gstm7;gdf15;foxo3;fn1;fga;esr1;erbb3;egr1;dusp6;ddit4;cyp2j4;bmf;ahsg;acaa2 TSKU_10094;SIRT3_9828;PARP1_9425;NFKBIA_9307;HYOU1_8857;HTRA1_8856;HSPB1_8847;HMGCR_8810;HADH_8776;GSTM7_8761;GDF15_33113;FOXO3_8662;FN1_8655;FGA_8632;ESR1_33192;ERBB3_8571;EGR1_8533;DUSP6_8506;DDIT4_8450;CYP2J4_32580;BMF_8152;AHSG_8003;ACAA2_7955 37.575717304347826 28.5803 0.520151 32.62689385598183 43.95660054740895 32.18601819108465 26.63833982608696 22.529 0.160202 23.650872800297332 31.649967954584184 23.91497247092234 60.882198260869565 38.8511 2.88499 58.551616067139555 64.82939021643038 48.38741943574293 15.5 50.94645 1.38416;2.38018;26.9741;0.520151;40.1982;33.1323;89.1011;1.63089;33.3125;42.3152;105.149;13.1992;59.5777;28.5803;23.3972;60.9984;0.750017;62.3934;87.5421;17.8395;94.8767;12.402;26.5872 0.540568;0.56209;21.799;0.160202;29.3844;25.6145;60.3265;0.663137;25.7336;31.4035;85.3487;5.6804;31.0499;22.529;18.3088;41.6036;0.186019;39.0875;53.2453;14.6501;73.1342;10.3013;21.3695 4.10872;8.82917;35.2797;2.88499;62.3571;46.6629;106.138;7.6286;46.9856;64.5991;125.652;32.7581;105.243;38.8511;31.9156;113.972;4.70178;133.304;245.492;22.6149;109.848;15.4235;35.0407 8 15 8 293615;25591;113965;81869;29496;65210;246142;170465 SIRT3_9828;PARP1_9425;HADH_8776;GSTM7_8761;ERBB3_8571;CYP2J4_32580;BMF_8152;ACAA2_7955 38.1604725 30.1433 28.613964655357535 28.781948749999998 23.7663 21.538860029050117 54.64614625 41.13265 38.93066299724933 2.38018;26.9741;33.3125;42.3152;60.9984;17.8395;94.8767;26.5872 0.56209;21.799;25.7336;31.4035;41.6036;14.6501;73.1342;21.3695 8.82917;35.2797;46.9856;64.5991;113.972;22.6149;109.848;35.0407 15 308843;25493;192235;65164;24471;25675;29455;294515;25661;361969;24890;24330;116663;140942;25373 TSKU_10094;NFKBIA_9307;HYOU1_8857;HTRA1_8856;HSPB1_8847;HMGCR_8810;GDF15_33113;FOXO3_8662;FN1_8655;FGA_8632;ESR1_33192;EGR1_8533;DUSP6_8506;DDIT4_8450;AHSG_8003 37.263847866666666 28.5803 35.540525358665896 25.495081733333336 22.529 25.357697835938087 64.20809266666667 38.8511 67.7897023144519 1.38416;0.520151;40.1982;33.1323;89.1011;1.63089;105.149;13.1992;59.5777;28.5803;23.3972;0.750017;62.3934;87.5421;12.402 0.540568;0.160202;29.3844;25.6145;60.3265;0.663137;85.3487;5.6804;31.0499;22.529;18.3088;0.186019;39.0875;53.2453;10.3013 4.10872;2.88499;62.3571;46.6629;106.138;7.6286;125.652;32.7581;105.243;38.8511;31.9156;4.70178;133.304;245.492;15.4235 0 Exp 2,6(0.27);Exp 4,3(0.14);Hill,3(0.14);Linear,7(0.31);Poly 2,3(0.14);Power,1(0.05) 2.019174471057314 48.88792586326599 1.5209722518920898 4.21828556060791 0.781048581907568 1.7792335748672485 24.241489100778274 50.90994550791738 16.97250597365784 36.30417367851607 36.95284066485412 84.81155585688501 DOWN 0.34782608695652173 0.6521739130434783 0.0 GO:0007611 5 learning or memory 75 79 4 4 4 4 4 4 158 75 2310 0.42753 0.75202 0.81586 5.06 24516;25675;314322;24330 jun;hmgcr;fos;egr1 JUN_8938;HMGCR_8810;FOS_8657;EGR1_8533 4.70332675000032 1.1904535 1.28141E-12 7.847737835056137 4.842561126749264 8.046759012927446 2.84288900000032 0.424578 1.28141E-12 5.127285963153043 2.93040012466531 5.26551691129057 13.064845000000322 6.16519 1.28142E-12 18.183019685338905 13.429984866031788 18.519755430643333 2.5 9.031645000000001 16.4324;1.63089;1.28141E-12;0.750017 10.5224;0.663137;1.28141E-12;0.186019 39.929;7.6286;1.28142E-12;4.70178 0 4 0 4 24516;25675;314322;24330 JUN_8938;HMGCR_8810;FOS_8657;EGR1_8533 4.70332675000032 1.1904535 7.847737835056137 2.84288900000032 0.424578 5.127285963153043 13.064845000000322 6.16519 18.183019685338905 16.4324;1.63089;1.28141E-12;0.750017 10.5224;0.663137;1.28141E-12;0.186019 39.929;7.6286;1.28142E-12;4.70178 0 Exp 4,1(0.25);Hill,2(0.5);Poly 2,1(0.25) 2.3423709527697762 9.995229721069336 1.8966681957244873 4.21828556060791 1.1469298131729728 1.9401379823684692 -2.9874563283546927 12.394109828355335 -2.181851243889662 7.867629243890303 -4.754514291631809 30.88420429163245 DOWN 0.0 1.0 0.0 GO:0045776 5 negative regulation of blood pressure 16 18 2 2 2 2 2 2 160 16 2369 0.89794 0.31912 0.31912 11.11 25513;29184 pik3r1;cd36 PIK3R1_32562;CD36_8243 33.431 33.431 18.7324 20.78695946789718 40.26260737327189 18.405324374074848 24.6067 24.6067 11.6701 18.295115170995782 30.6193659644503 16.198979446862733 55.36995 55.36995 41.5978 19.476761313036615 61.77096244239631 17.24524023229528 0.0 18.7324 0.5 33.431 18.7324;48.1296 11.6701;37.5433 41.5978;69.1421 1 1 1 29184 CD36_8243 48.1296 48.1296 37.5433 37.5433 69.1421 69.1421 48.1296 37.5433 69.1421 1 25513 PIK3R1_32562 18.7324 18.7324 11.6701 11.6701 41.5978 41.5978 18.7324 11.6701 41.5978 0 Exp 2,1(0.5);Poly 2,1(0.5) 2.11399592616056 4.3438907861709595 1.6735800504684448 2.6703107357025146 0.704795026545725 2.1719453930854797 4.621743999999996 62.240256 -0.7490360000000003 49.96243600000001 28.376536000000005 82.363364 CONFLICT 0.5 0.5 0.0 GO:0030336 7 negative regulation of cell migration 73 78 3 3 3 3 3 3 159 75 2310 0.25707 0.8841 0.48158 3.85 83516;25112;294515 ppargc1a;gadd45a;foxo3 PPARGC1A_33189;GADD45A_8678;FOXO3_8662 52.842533333333336 42.4094 13.1992 45.76077284501795 72.4711806742963 42.4465573211921 40.49346666666667 26.2988 5.6804 43.67605808098222 58.77720875966594 42.18449119719839 76.64186666666667 81.7305 32.7581 41.5736787908327 94.90976333436436 32.683192168185464 42.4094;102.919;13.1992 26.2988;89.5012;5.6804 81.7305;115.437;32.7581 0 3 0 3 83516;25112;294515 PPARGC1A_33189;GADD45A_8678;FOXO3_8662 52.842533333333336 42.4094 45.76077284501795 40.49346666666667 26.2988 43.67605808098222 76.64186666666667 81.7305 41.5736787908327 42.4094;102.919;13.1992 26.2988;89.5012;5.6804 81.7305;115.437;32.7581 0 Exp 2,1(0.34);Exp 4,1(0.34);Poly 2,1(0.34) 1.7873914493405532 5.37992787361145 1.6339634656906128 1.9883413314819336 0.1798639691096815 1.7576230764389038 1.0593440733563142 104.62572259331034 -8.930645758119113 89.91757909145244 29.596820370129677 123.68691296320367 DOWN 0.0 1.0 0.0 GO:0001503 3 ossification 29 30 2 2 2 2 2 2 160 28 2357 0.70272 0.57847 0.7161 6.67 25661;25373 fn1;ahsg FN1_8655;AHSG_8003 35.98985 35.98985 12.402 33.358257377222216 46.93886822670991 29.546765220364634 20.6756 20.6756 10.3013 14.671475760127203 25.491146978183966 12.995122761321126 60.33325 60.33325 15.4235 63.51197753278509 81.1794768204599 56.255141496799 0.5 35.98985 59.5777;12.402 31.0499;10.3013 105.243;15.4235 0 2 0 2 25661;25373 FN1_8655;AHSG_8003 35.98985 35.98985 33.358257377222216 20.6756 20.6756 14.671475760127203 60.33325 60.33325 63.51197753278509 59.5777;12.402 31.0499;10.3013 105.243;15.4235 0 Exp 2,1(0.5);Power,1(0.5) 2.4708900885537544 5.21065366268158 1.7792335748672485 3.431420087814331 1.1682722870898377 2.60532683134079 -10.242335999999987 82.222036 0.3419719999999984 41.009228 -27.68985999999999 148.35636 DOWN 0.0 1.0 0.0 GO:2000121 7 regulation of removal of superoxide radicals 5 6 3 3 3 3 3 3 159 3 2382 0.99979 0.0043808 0.0043808 50.0 293615;25106;29184 sirt3;rgn;cd36 SIRT3_9828;RGN_9699;CD36_8243 42.65016000000001 48.1296 2.38018 37.82907099973247 43.89811870484123 34.01504547378316 32.29286333333334 37.5433 0.56209 29.458592053101135 33.455830349297244 26.5247745605707 55.92532333333333 69.1421 8.82917 42.07459451720996 58.69584405153565 38.22146185085524 0.0 2.38018 0.0 2.38018 2.38018;77.4407;48.1296 0.56209;58.7732;37.5433 8.82917;89.8047;69.1421 3 0 3 293615;25106;29184 SIRT3_9828;RGN_9699;CD36_8243 42.65016000000001 48.1296 37.82907099973247 32.29286333333334 37.5433 29.458592053101135 55.92532333333333 69.1421 42.07459451720996 2.38018;77.4407;48.1296 0.56209;58.7732;37.5433 8.82917;89.8047;69.1421 0 0 Exp 2,1(0.34);Hill,1(0.34);Poly 2,1(0.34) 1.9115880060184967 5.911169528961182 1.5209722518920898 2.6703107357025146 0.6142545609793905 1.7198865413665771 -0.15746367678244866 85.45778367678247 -1.0426717282050788 65.62839839487175 8.31343753104452 103.53720913562213 UP 1.0 0.0 0.0 GO:0090092 6 regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 55 58 3 3 3 3 3 3 159 55 2330 0.49014 0.72538 1.0 5.17 25591;65164;29455 parp1;htra1;gdf15 PARP1_9425;HTRA1_8856;GDF15_33113 55.08513333333334 33.1323 26.9741 43.465778677292015 53.849694123706726 42.94445976504901 44.25406666666667 25.6145 21.799 35.640092265078835 43.246042182111346 35.20570341168191 69.1982 46.6629 35.2797 49.2206050490036 67.78330422806468 48.658288205026686 1.5 69.14065 26.9741;33.1323;105.149 21.799;25.6145;85.3487 35.2797;46.6629;125.652 1 2 1 25591 PARP1_9425 26.9741 26.9741 21.799 21.799 35.2797 35.2797 26.9741 21.799 35.2797 2 65164;29455 HTRA1_8856;GDF15_33113 69.14065 69.14065 50.92349692867727 55.4816 55.4816 42.23845788875345 86.15745 86.15745 55.85372824982233 33.1323;105.149 25.6145;85.3487 46.6629;125.652 0 Exp 2,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 1.6391633984366407 4.929597616195679 1.5603101253509521 1.8086696863174438 0.14330172262839 1.5606178045272827 5.898974454385694 104.27129221228097 3.923505614821366 84.58462771851195 13.499842033551758 124.89655796644824 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:1901575 4 organic substance catabolic process 296 332 53 53 36 45 31 31 131 301 2084 0.99165 0.014815 0.021621 9.34 79426;312688;286954;360268;65192;29676;24651;24539;289456;24443;171155;113965;85255;114860;308441;295143;65030;171142;291075;29740;25428;83842;497840;81718;25377;50681;192272;24158;25287;170465;296925 zfp36;usp18;ugt2b1;sult1e1;slc27a2;psmb3;pklr;lpl;hsd17b11;hdc;hadhb;hadh;hacl1;gale;exosc5;etfdh;ephx2;ehhadh;eci2;eci1;cyp7a1;crot;cps1;cdo1;ambp;acox1;acot2;acadm;acadl;acaa2;aass ZFP36_10204;USP18_10138;UGT2B10_33303,UGT2B1_33224;SULT1E1_32446;SLC27A2_9860;PSMB3_9589;PKLR_9489;LPL_32544;HSD17B11_8832;HDC_8788;HADHB_8777;HADH_8776;HACL1_8775;GALE_8680;EXOSC5_32543;ETFDH_8575;EPHX2_33282;EHHADH_8534;ECI2_8521;ECI1_8520;CYP7A1_8430;CROT_8384;CPS1_32421;CDO1_8275;AMBP_33085;ACOX1_7973;ACOT2_7969;ACADM_7957;ACADL_32776;ACAA2_7955;AASS_7936 28.478196580645168 23.1906 0.348134 23.046668998493455 29.934939902493053 22.450369437582797 20.84836564516129 18.5144 0.118102 15.456596480519835 22.02572672057353 14.91779319595716 41.89808612903225 32.9443 1.15962 35.154508581464086 45.78682348199659 39.04043129775207 15.5 23.4897 0.348134;108.883;47.47345;50.1846;7.62189;23.7888;23.0963;74.2041;22.4334;24.5745;31.8029;33.3125;17.6275;71.148;41.9329;18.1231;38.7293;8.62809;10.6467;11.9473;5.72128;7.4229;31.9826;22.9638;17.2343;23.1906;8.54905;11.7137;33.4878;26.5872;27.4644 0.118102;73.1414;34.82915;36.5009;5.49916;19.2724;17.4625;49.8682;18.1233;21.0619;25.5756;25.7336;11.195;43.2839;31.7336;14.869;29.2097;7.31865;8.92359;7.15307;0.985273;5.75707;24.4836;18.5144;14.1233;16.2815;7.19676;8.36151;26.6039;21.3695;21.7498 1.15962;138.144;76.47475;80.9788;13.3925;30.901;32.9443;155.425;29.2247;29.28;42.1484;46.9856;37.6534;88.9033;62.1373;23.0103;57.2113;10.3909;13.0581;19.001;22.3625;10.316;45.5891;30.0179;21.9073;33.4539;10.4125;18.9642;45.3228;35.0407;37.0295 25 7 24 312688;286954;360268;65192;29676;24539;289456;24443;171155;113965;85255;308441;295143;65030;171142;291075;29740;83842;50681;192272;24158;25287;170465;296925 USP18_10138;UGT2B10_33303,UGT2B1_33224;SULT1E1_32446;SLC27A2_9860;PSMB3_9589;LPL_32544;HSD17B11_8832;HDC_8788;HADHB_8777;HADH_8776;HACL1_8775;EXOSC5_32543;ETFDH_8575;EPHX2_33282;EHHADH_8534;ECI2_8521;ECI1_8520;CROT_8384;ACOX1_7973;ACOT2_7969;ACADM_7957;ACADL_32776;ACAA2_7955;AASS_7936 29.597070000000006 24.181649999999998 23.38380548985316 21.972010833333332 20.16715 15.78923265210571 43.99819374999999 34.247299999999996 37.34912679189468 108.883;47.47345;50.1846;7.62189;23.7888;74.2041;22.4334;24.5745;31.8029;33.3125;17.6275;41.9329;18.1231;38.7293;8.62809;10.6467;11.9473;7.4229;23.1906;8.54905;11.7137;33.4878;26.5872;27.4644 73.1414;34.82915;36.5009;5.49916;19.2724;49.8682;18.1233;21.0619;25.5756;25.7336;11.195;31.7336;14.869;29.2097;7.31865;8.92359;7.15307;5.75707;16.2815;7.19676;8.36151;26.6039;21.3695;21.7498 138.144;76.47475;80.9788;13.3925;30.901;155.425;29.2247;29.28;42.1484;46.9856;37.6534;62.1373;23.0103;57.2113;10.3909;13.0581;19.001;10.316;33.4539;10.4125;18.9642;45.3228;35.0407;37.0295 7 79426;24651;114860;25428;497840;81718;25377 ZFP36_10204;PKLR_9489;GALE_8680;CYP7A1_8430;CPS1_32421;CDO1_8275;AMBP_33085 24.642059142857143 22.9638 23.183893755147743 16.99586785714286 17.4625 14.714506595616797 34.697717142857144 30.0179 27.45420097242054 0.348134;23.0963;71.148;5.72128;31.9826;22.9638;17.2343 0.118102;17.4625;43.2839;0.985273;24.4836;18.5144;14.1233 1.15962;32.9443;88.9033;22.3625;45.5891;30.0179;21.9073 0 Exp 2,14(0.44);Hill,4(0.13);Linear,8(0.25);Poly 2,4(0.13);Power,2(0.07) 2.842829557449251 142.1393188238144 1.559399127960205 32.73371124267578 6.3539144164638435 1.9334938526153564 20.365160846121526 36.591232315168796 15.407235753949378 26.289495536373202 29.52277131153391 54.27340094653059 UP 0.7741935483870968 0.22580645161290322 0.0 GO:0034641 4 cellular nitrogen compound metabolic process 478 543 69 68 46 61 40 40 122 503 1882 0.8803 0.16237 0.27645 7.37 79426;24856;360268;297784;293656;298490;29441;303612;24651;81819;25591;294103;100359982;24516;364070;63868;25675;24443;81869;57298;29328;499914;294515;314322;308441;24890;24330;83842;497840;25698;25028;192272;170570;50559;24158;25287;170465;312382;25303;296925 zfp36;ttr;sult1e1;rrs1;rgd1307603;ppcs;por;polg2;pklr;pax8;parp1;papss2;mpc2;jun;iars2;hspd1;hmgcr;hdc;gstm7;gstm3l;gpx4;gins1;foxo3;fos;exosc5;esr1;egr1;crot;cps1;ass1;ampd1;acot2;acot12;acot1;acadm;acadl;acaa2;abcg2;abcc2;aass ZFP36_10204;TTR_10102;SULT1E1_32446;RRS1_9755;RGD1307603_9684;PPCS_9540;POR_9531;POLG2_9521;PKLR_9489;PAX8_9432;PARP1_9425;PAPSS2_33237;MPC2_33219;JUN_8938;IARS2_8858;HSPD1_8849;HMGCR_8810;HDC_8788;GSTM7_8761;GSTM3_8760;GPX4_32827;GINS1_8707;FOXO3_8662;FOS_8657;EXOSC5_32543;ESR1_33192;EGR1_8533;CROT_8384;CPS1_32421;ASS1_33159;AMPD1_32743;ACOT2_7969;ACOT12_32718;ACOT1_7968;ACADM_7957;ACADL_32776;ACAA2_7955;ABCG2_32656;ABCC2_32541;AASS_7936 30.854220775000034 28.903350000000003 1.28141E-12 19.485823249388982 33.496432638516964 19.174661076400778 22.791827200000036 22.87295 1.28141E-12 14.339722537070173 24.89479278358959 14.306822408981443 50.34873250000003 40.51575 1.28142E-12 34.542858166134025 54.30849375692642 33.46892109323802 26.5 42.0954 0.348134;46.6406;50.1846;60.39;34.7372;20.3353;12.4414;63.7758;23.0963;56.8931;26.9741;34.4443;46.8463;16.4324;24.7304;42.2579;1.63089;24.5745;42.3152;73.0961;45.9204;58.9165;13.1992;1.28141E-12;41.9329;23.3972;0.750017;7.4229;31.9826;26.8037;60.9045;8.54905;30.3423;31.2018;11.7137;33.4878;26.5872;5.21654;46.2316;27.4644 0.118102;28.5876;36.5009;43.109;26.1766;16.7643;8.48981;40.9553;17.4625;45.1162;21.799;25.719;35.8494;10.5224;19.8021;23.9469;0.663137;21.0619;31.4035;51.4219;34.2198;44.7208;5.6804;1.28141E-12;31.7336;18.3088;0.186019;5.75707;24.4836;20.9825;50.0633;7.19676;24.0157;26.858;8.36151;26.6039;21.3695;2.73368;31.1788;21.7498 1.15962;63.7146;80.9788;104.942;50.9085;25.6711;79.2355;132.567;32.9443;81.5688;35.2797;51.1014;69.127;39.929;32.7087;102.383;7.6286;29.28;64.5991;140.853;70.4292;91.837;32.7581;1.28142E-12;62.1373;31.9156;4.70178;10.316;45.5891;36.7081;82.6625;10.4125;41.1025;37.2719;18.9642;45.3228;35.0407;11.386;81.7848;37.0295 25 15 25 24856;360268;297784;298490;81819;25591;100359982;364070;63868;24443;81869;57298;29328;499914;308441;83842;25028;192272;170570;50559;24158;25287;170465;312382;296925 TTR_10102;SULT1E1_32446;RRS1_9755;PPCS_9540;PAX8_9432;PARP1_9425;MPC2_33219;IARS2_8858;HSPD1_8849;HDC_8788;GSTM7_8761;GSTM3_8760;GPX4_32827;GINS1_8707;EXOSC5_32543;CROT_8384;AMPD1_32743;ACOT2_7969;ACOT12_32718;ACOT1_7968;ACADM_7957;ACADL_32776;ACAA2_7955;ABCG2_32656;AASS_7936 36.1959236 33.4878 18.384239623223216 27.229844800000006 26.6039 13.493842372499662 55.40071600000001 45.3228 33.65329359162188 46.6406;50.1846;60.39;20.3353;56.8931;26.9741;46.8463;24.7304;42.2579;24.5745;42.3152;73.0961;45.9204;58.9165;41.9329;7.4229;60.9045;8.54905;30.3423;31.2018;11.7137;33.4878;26.5872;5.21654;27.4644 28.5876;36.5009;43.109;16.7643;45.1162;21.799;35.8494;19.8021;23.9469;21.0619;31.4035;51.4219;34.2198;44.7208;31.7336;5.75707;50.0633;7.19676;24.0157;26.858;8.36151;26.6039;21.3695;2.73368;21.7498 63.7146;80.9788;104.942;25.6711;81.5688;35.2797;69.127;32.7087;102.383;29.28;64.5991;140.853;70.4292;91.837;62.1373;10.316;82.6625;10.4125;41.1025;37.2719;18.9642;45.3228;35.0407;11.386;37.0295 15 79426;293656;29441;303612;24651;294103;24516;25675;294515;314322;24890;24330;497840;25698;25303 ZFP36_10204;RGD1307603_9684;POR_9531;POLG2_9521;PKLR_9489;PAPSS2_33237;JUN_8938;HMGCR_8810;FOXO3_8662;FOS_8657;ESR1_33192;EGR1_8533;CPS1_32421;ASS1_33159;ABCC2_32541 21.95138273333342 23.0963 18.505628485998166 15.395131200000085 17.4625 12.918427056505077 41.92876000000009 36.7081 35.5091440999847 0.348134;34.7372;12.4414;63.7758;23.0963;34.4443;16.4324;1.63089;13.1992;1.28141E-12;23.3972;0.750017;31.9826;26.8037;46.2316 0.118102;26.1766;8.48981;40.9553;17.4625;25.719;10.5224;0.663137;5.6804;1.28141E-12;18.3088;0.186019;24.4836;20.9825;31.1788 1.15962;50.9085;79.2355;132.567;32.9443;51.1014;39.929;7.6286;32.7581;1.28142E-12;31.9156;4.70178;45.5891;36.7081;81.7848 0 Exp 2,24(0.6);Exp 3,1(0.03);Exp 4,3(0.08);Hill,3(0.08);Linear,4(0.1);Poly 2,5(0.13) 2.5193073833463724 451.1734970808029 1.5074360370635986 344.14306640625 54.060583608405246 1.905015468597412 24.815501586949864 36.89293996305021 18.347901145265006 27.23575325473506 39.64378984768125 61.05367515231882 UP 0.625 0.375 0.0 GO:0034762 5 regulation of transmembrane transport 122 128 12 11 10 9 8 8 154 120 2265 0.57195 0.5757 1.0 6.25 246273;362895;29482;25106;83516;81869;24890;29496 trib3;stac3;slc1a2;rgn;ppargc1a;gstm7;esr1;erbb3 TRIB3_10079;STAC3_9953;SLC1A2_33059;RGN_9699;PPARGC1A_33189;GSTM7_8761;ESR1_33192;ERBB3_8571 53.898462499999994 51.7039 13.3235 30.398843681295208 55.05868335771381 28.453129436961866 39.010515 36.503550000000004 9.10952 23.80456628166898 39.43182915835119 22.45043152498702 83.9559 85.7676 24.6773 42.23226654267359 87.65918590721488 39.45502988400801 5.5 70.34 108.064;63.2393;13.3235;77.4407;42.4094;42.3152;23.3972;60.9984 83.8836;42.7031;9.10952;58.7732;26.2988;31.4035;18.3088;41.6036 143.428;121.52;24.6773;89.8047;81.7305;64.5991;31.9156;113.972 3 5 3 25106;81869;29496 RGN_9699;GSTM7_8761;ERBB3_8571 60.25143333333333 60.9984 17.57465951201709 43.92676666666667 41.6036 13.831953840413616 89.45859999999999 89.8047 24.68826953251284 77.4407;42.3152;60.9984 58.7732;31.4035;41.6036 89.8047;64.5991;113.972 5 246273;362895;29482;83516;24890 TRIB3_10079;STAC3_9953;SLC1A2_33059;PPARGC1A_33189;ESR1_33192 50.086679999999994 42.4094 37.607051937861335 36.060764 26.2988 29.444617465514472 80.65428 81.7305 52.72709564661231 108.064;63.2393;13.3235;42.4094;23.3972 83.8836;42.7031;9.10952;26.2988;18.3088 143.428;121.52;24.6773;81.7305;31.9156 0 Exp 2,2(0.25);Linear,3(0.38);Poly 2,3(0.38) 1.914910681247327 15.642555236816406 1.6013026237487793 2.879150867462158 0.4575931504023042 1.7538878917694092 32.83313856287181 74.96378643712819 22.51479216384669 55.50623783615332 54.6904323839418 113.2213676160582 DOWN 0.375 0.625 0.0 GO:0042221 3 response to chemical 909 981 120 119 90 110 83 83 79 898 1487 0.99975 4.5983E-4 8.015E-4 8.46 79426;24522;312688;286954;246273;24825;170698;29573;25351;29482;24648;246074;83516;29441;298199;24651;25513;81819;25591;24314;81525;25493;24567;24552;24539;89783;58954;24516;81678;54404;494344;192235;63868;24471;29540;24464;25675;113965;81869;29328;24957;24384;294515;314322;25661;25256;246186;361969;24360;304929;24890;29496;65030;25315;116636;24330;116663;140942;25428;65210;25146;25423;83842;497840;113936;367313;170945;81718;114851;29184;54232;25698;65054;155423;25028;65183;25373;192272;24158;170465;312382;140668;25303 zfp36;zfp354a;usp18;ugt2b1;trib3;tf;slco1a2;slc37a4;slc2a2;slc1a2;serpina1;scd;ppargc1a;por;plin2;pklr;pik3r1;pax8;parp1;nqo1;nfkbib;nfkbia;mt1;me1;lpl;laptm5;klf6;jun;itpr2;itih4;ier2;hyou1;hspd1;hspb1;hsd17b7;hp;hmgcr;hadh;gstm7;gpx4;glul;gc;foxo3;fos;fn1;fmo1;fgl1;fga;fabp1;f5;esr1;erbb3;ephx2;ephx1;eif4ebp1;egr1;dusp6;ddit4;cyp7a1;cyp2j4;cyp17a1;ctsc;crot;cps1;cpb2;col6a3;chrna2;cdo1;cdkn1a;cd36;car3;ass1;aqp9;anxa7;ampd1;aldh3a2;ahsg;acot2;acadm;acaa2;abcg2;abcc3;abcc2 ZFP36_10204;ZFP354A_10203;USP18_10138;UGT2B10_33303,UGT2B1_33224;TRIB3_10079;TF_10003;SLCO1A2_9886;SLC37A4_9871;SLC2A2_9863;SLC1A2_33059;SERPINA1_9807;SCD1_9787;PPARGC1A_33189;POR_9531;PLIN2_9502;PKLR_9489;PIK3R1_32562;PAX8_9432;PARP1_9425;NQO1_33055;NFKBIB_9308;NFKBIA_9307;MT1A_9255;ME1_9215;LPL_32544;LAPTM5_32639;KLF6_8969;JUN_8938;ITPR2_8931;ITIH4_32725;IER2_32643;HYOU1_8857;HSPD1_8849;HSPB1_8847;HSD17B7_8834;HP_8823;HMGCR_8810;HADH_8776;GSTM7_8761;GPX4_32827;GLUL_32832;GC_32893;FOXO3_8662;FOS_8657;FN1_8655;FMO1_32787;FGL1_8640;FGA_8632;FABP1_33091;F5_33079;ESR1_33192;ERBB3_8571;EPHX2_33282;EPHX1_8567;EIF4EBP1_8550;EGR1_8533;DUSP6_8506;DDIT4_8450;CYP7A1_8430;CYP2J4_32580;CYP17A1_32365;CTSC_32456;CROT_8384;CPS1_32421;CPB2_8369;COL6A3_33029;CHRNA2_32401;CDO1_8275;CDKN1A_8271;CD36_8243;CAR3_8196;ASS1_33159;AQP9_32709;ANXA7_8051;AMPD1_32743;ALDH3A2_8024;AHSG_8003;ACOT2_7969;ACADM_7957;ACAA2_7955;ABCG2_32656;ABCC3_7941;ABCC2_32541 38.56065063855422 33.3125 1.28141E-12 28.553516226628272 39.97074168993704 25.65626885847792 26.382778132530138 24.4836 1.28141E-12 19.16155693152267 27.228684695925875 16.804553955229387 65.94988710843376 46.9856 1.28142E-12 60.73519163144462 67.06489944321821 52.922447854075585 48.5 42.28655 0.348134;0.834827;108.883;47.47345;108.064;45.1539;104.197;39.7166;29.7555;13.3235;15.797;105.46;42.4094;12.4414;25.6517;23.0963;18.7324;56.8931;26.9741;87.2765;30.5572;0.520151;12.9315;80.7944;74.2041;38.674;18.9476;16.4324;31.8111;57.1163;49.6814;40.1982;42.2579;89.1011;0.977494;64.9285;1.63089;33.3125;42.3152;45.9204;26.4669;42.356;13.1992;1.28141E-12;59.5777;65.2792;15.4757;28.5803;33.8478;10.6089;23.3972;60.9984;38.7293;12.4747;83.9001;0.750017;62.3934;87.5421;5.72128;17.8395;49.6922;56.2386;7.4229;31.9826;25.8316;63.132;49.3913;22.9638;6.24967;48.1296;53.9626;26.8037;27.7316;104.64;60.9045;43.1079;12.402;8.54905;11.7137;26.5872;5.21654;37.7175;46.2316 0.118102;0.27095;73.1414;34.82915;83.8836;28.132;80.3101;22.6911;23.3399;9.10952;13.013;63.7532;26.2988;8.48981;20.9252;17.4625;11.6701;45.1162;21.799;60.6992;24.2439;0.160202;8.91033;59.856;49.8682;24.6273;11.6941;10.5224;24.7342;39.6402;33.4626;29.3844;23.9469;60.3265;0.322682;41.6103;0.663137;25.7336;31.4035;34.2198;21.0456;26.3722;5.6804;1.28141E-12;31.0499;39.7882;10.2138;22.529;26.4736;2.59129;18.3088;41.6036;29.2097;7.00435;42.4185;0.186019;39.0875;53.2453;0.985273;14.6501;35.6654;38.2681;5.75707;24.4836;20.4374;42.651;41.8524;18.5144;2.44025;37.5433;28.5034;20.9825;21.9372;43.9254;50.0633;31.8774;10.3013;7.19676;8.36151;21.3695;2.73368;30.9007;31.1788 1.15962;2.99857;138.144;76.47475;143.428;61.5341;128.412;60.0334;40.808;24.6773;19.9134;422.699;81.7305;79.2355;33.0375;32.9443;41.5978;81.5688;35.2797;197.117;41.2611;2.88499;23.4636;94.0621;155.425;71.0786;45.5481;39.929;44.3296;101.869;89.4404;62.3571;102.383;106.138;5.49472;136.455;7.6286;46.9856;64.5991;70.4292;35.4303;78.7583;32.7581;1.28142E-12;105.243;82.9415;30.4106;38.8511;46.9257;37.5078;31.9156;113.972;57.2113;23.684;107.32;4.70178;133.304;245.492;22.3625;22.6149;81.6409;102.888;10.316;45.5891;34.8042;121.149;62.472;30.0179;19.0606;69.1421;77.0288;36.7081;37.4625;108.689;82.6625;66.3058;15.4235;10.4125;18.9642;35.0407;11.386;48.9329;81.7848 34 50 33 312688;286954;24825;246074;298199;81819;25591;24314;81525;24539;63868;113965;81869;29328;25256;24360;29496;65030;25315;116636;65210;25146;83842;170945;29184;155423;25028;65183;192272;24158;170465;312382;140668 USP18_10138;UGT2B10_33303,UGT2B1_33224;TF_10003;SCD1_9787;PLIN2_9502;PAX8_9432;PARP1_9425;NQO1_33055;NFKBIB_9308;LPL_32544;HSPD1_8849;HADH_8776;GSTM7_8761;GPX4_32827;FMO1_32787;FABP1_33091;ERBB3_8571;EPHX2_33282;EPHX1_8567;EIF4EBP1_8550;CYP2J4_32580;CYP17A1_32365;CROT_8384;CHRNA2_32401;CD36_8243;ANXA7_8051;AMPD1_32743;ALDH3A2_8024;ACOT2_7969;ACADM_7957;ACAA2_7955;ABCG2_32656;ABCC3_7941 46.62043757575758 43.1079 28.132138953493882 32.006233939393944 31.4035 16.866921155960103 78.41126818181819 64.5991 75.14101186632352 108.883;47.47345;45.1539;105.46;25.6517;56.8931;26.9741;87.2765;30.5572;74.2041;42.2579;33.3125;42.3152;45.9204;65.2792;33.8478;60.9984;38.7293;12.4747;83.9001;17.8395;49.6922;7.4229;49.3913;48.1296;104.64;60.9045;43.1079;8.54905;11.7137;26.5872;5.21654;37.7175 73.1414;34.82915;28.132;63.7532;20.9252;45.1162;21.799;60.6992;24.2439;49.8682;23.9469;25.7336;31.4035;34.2198;39.7882;26.4736;41.6036;29.2097;7.00435;42.4185;14.6501;35.6654;5.75707;41.8524;37.5433;43.9254;50.0633;31.8774;7.19676;8.36151;21.3695;2.73368;30.9007 138.144;76.47475;61.5341;422.699;33.0375;81.5688;35.2797;197.117;41.2611;155.425;102.383;46.9856;64.5991;70.4292;82.9415;46.9257;113.972;57.2113;23.684;107.32;22.6149;81.6409;10.316;62.472;69.1421;108.689;82.6625;66.3058;10.4125;18.9642;35.0407;11.386;48.9329 50 79426;24522;246273;170698;29573;25351;29482;24648;83516;29441;24651;25513;25493;24567;24552;89783;58954;24516;81678;54404;494344;192235;24471;29540;24464;25675;24957;24384;294515;314322;25661;246186;361969;304929;24890;24330;116663;140942;25428;25423;497840;113936;367313;81718;114851;54232;25698;65054;25373;25303 ZFP36_10204;ZFP354A_10203;TRIB3_10079;SLCO1A2_9886;SLC37A4_9871;SLC2A2_9863;SLC1A2_33059;SERPINA1_9807;PPARGC1A_33189;POR_9531;PKLR_9489;PIK3R1_32562;NFKBIA_9307;MT1A_9255;ME1_9215;LAPTM5_32639;KLF6_8969;JUN_8938;ITPR2_8931;ITIH4_32725;IER2_32643;HYOU1_8857;HSPB1_8847;HSD17B7_8834;HP_8823;HMGCR_8810;GLUL_32832;GC_32893;FOXO3_8662;FOS_8657;FN1_8655;FGL1_8640;FGA_8632;F5_33079;ESR1_33192;EGR1_8533;DUSP6_8506;DDIT4_8450;CYP7A1_8430;CTSC_32456;CPS1_32421;CPB2_8369;COL6A3_33029;CDO1_8275;CDKN1A_8271;CAR3_8196;ASS1_33159;AQP9_32709;AHSG_8003;ABCC2_32541 33.24119126000003 26.6353 27.837355638539314 22.671297300000024 21.01405 19.831665461453344 57.725375600000014 40.3685 48.08465024460898 0.348134;0.834827;108.064;104.197;39.7166;29.7555;13.3235;15.797;42.4094;12.4414;23.0963;18.7324;0.520151;12.9315;80.7944;38.674;18.9476;16.4324;31.8111;57.1163;49.6814;40.1982;89.1011;0.977494;64.9285;1.63089;26.4669;42.356;13.1992;1.28141E-12;59.5777;15.4757;28.5803;10.6089;23.3972;0.750017;62.3934;87.5421;5.72128;56.2386;31.9826;25.8316;63.132;22.9638;6.24967;53.9626;26.8037;27.7316;12.402;46.2316 0.118102;0.27095;83.8836;80.3101;22.6911;23.3399;9.10952;13.013;26.2988;8.48981;17.4625;11.6701;0.160202;8.91033;59.856;24.6273;11.6941;10.5224;24.7342;39.6402;33.4626;29.3844;60.3265;0.322682;41.6103;0.663137;21.0456;26.3722;5.6804;1.28141E-12;31.0499;10.2138;22.529;2.59129;18.3088;0.186019;39.0875;53.2453;0.985273;38.2681;24.4836;20.4374;42.651;18.5144;2.44025;28.5034;20.9825;21.9372;10.3013;31.1788 1.15962;2.99857;143.428;128.412;60.0334;40.808;24.6773;19.9134;81.7305;79.2355;32.9443;41.5978;2.88499;23.4636;94.0621;71.0786;45.5481;39.929;44.3296;101.869;89.4404;62.3571;106.138;5.49472;136.455;7.6286;35.4303;78.7583;32.7581;1.28142E-12;105.243;30.4106;38.8511;37.5078;31.9156;4.70178;133.304;245.492;22.3625;102.888;45.5891;34.8042;121.149;30.0179;19.0606;77.0288;36.7081;37.4625;15.4235;81.7848 0 Exp 2,31(0.37);Exp 3,4(0.05);Exp 4,6(0.08);Hill,7(0.09);Linear,17(0.21);Poly 2,17(0.21);Power,2(0.03) 2.0300669150484487 186.10244727134705 1.5074360370635986 11.836054801940918 1.3566200912668775 1.7939516305923462 32.417705704264066 44.70359557284438 22.260400063525886 30.505156201534405 52.883442513508896 79.0163317033585 DOWN 0.39759036144578314 0.6024096385542169 0.0 GO:0003008 3 system process 296 309 26 26 21 23 18 18 144 291 2094 0.39697 0.69688 0.80347 5.83 362895;298490;83516;288001;24516;25675;314322;361969;80841;24360;304929;65030;24330;497840;170945;29184;312382;25303 stac3;ppcs;ppargc1a;kng1;jun;hmgcr;fos;fga;fabp7;fabp1;f5;ephx2;egr1;cps1;chrna2;cd36;abcg2;abcc2 STAC3_9953;PPCS_9540;PPARGC1A_33189;KNG1L1_34113;JUN_8938;HMGCR_8810;FOS_8657;FGA_8632;FABP7_8592;FABP1_33091;F5_33079;EPHX2_33282;EGR1_8533;CPS1_32421;CHRNA2_32401;CD36_8243;ABCG2_32656;ABCC2_32541 27.026763722222295 26.59065 1.28141E-12 18.870814143836963 30.783382643520106 18.812255109299723 19.428407000000067 21.0335 1.28141E-12 14.372821959513603 22.822670867184556 14.536813999688347 44.43406000000007 39.39005 1.28142E-12 31.168505991591125 48.511556823592755 30.81334726184178 14.5 47.1806 63.2393;20.3353;42.4094;24.3655;16.4324;1.63089;1.28141E-12;28.5803;24.601;33.8478;10.6089;38.7293;0.750017;31.9826;49.3913;48.1296;5.21654;46.2316 42.7031;16.7643;26.2988;19.538;10.5224;0.663137;1.28141E-12;22.529;14.4402;26.4736;2.59129;29.2097;0.186019;24.4836;41.8524;37.5433;2.73368;31.1788 121.52;25.6711;81.7305;32.1467;39.929;7.6286;1.28142E-12;38.8511;35.6155;46.9257;37.5078;57.2113;4.70178;45.5891;62.472;69.1421;11.386;81.7848 7 11 7 298490;80841;24360;65030;170945;29184;312382 PPCS_9540;FABP7_8592;FABP1_33091;EPHX2_33282;CHRNA2_32401;CD36_8243;ABCG2_32656 31.464405714285714 33.8478 15.903224427608857 24.14531142857143 26.4736 13.731002152631874 44.06052857142857 46.9257 20.92181441340707 20.3353;24.601;33.8478;38.7293;49.3913;48.1296;5.21654 16.7643;14.4402;26.4736;29.2097;41.8524;37.5433;2.73368 25.6711;35.6155;46.9257;57.2113;62.472;69.1421;11.386 11 362895;83516;288001;24516;25675;314322;361969;304929;24330;497840;25303 STAC3_9953;PPARGC1A_33189;KNG1L1_34113;JUN_8938;HMGCR_8810;FOS_8657;FGA_8632;F5_33079;EGR1_8533;CPS1_32421;ABCC2_32541 24.202809727272847 24.3655 20.76242717875751 16.426740545454663 19.538 14.579881135999374 44.67176181818194 38.8511 37.265474509020066 63.2393;42.4094;24.3655;16.4324;1.63089;1.28141E-12;28.5803;10.6089;0.750017;31.9826;46.2316 42.7031;26.2988;19.538;10.5224;0.663137;1.28141E-12;22.529;2.59129;0.186019;24.4836;31.1788 121.52;81.7305;32.1467;39.929;7.6286;1.28142E-12;38.8511;37.5078;4.70178;45.5891;81.7848 0 Exp 2,7(0.39);Exp 4,2(0.12);Hill,4(0.23);Linear,4(0.23);Poly 2,1(0.06) 2.1869253987228534 41.46308994293213 1.5074360370635986 4.642963409423828 0.864715135325391 1.9173309206962585 18.30889236577845 35.744635078666136 12.78850201672553 26.06831198327461 30.034944861876422 58.83317513812372 DOWN 0.3888888888888889 0.6111111111111112 0.0 GO:0065007 2 biological regulation 1742 1890 162 161 130 142 115 115 47 1775 610 0.19008 0.85516 0.35337 6.08 257644;79426;24522;312688;24856;308843;246273;25357;24825;360268;362895;170698;29573;29482;293615;79224;24794;24648;246074;297784;25106;308821;252922;192280;83516;29441;303612;298199;85253;363465;25513;360722;81819;25591;294103;24314;81525;25493;24567;100359982;24552;24539;299282;307582;288001;58954;24516;81678;54404;50693;306251;25685;494344;364070;192235;65164;63868;24471;29540;289456;24464;25675;24443;113965;81869;29328;290556;24957;29455;24384;299626;25112;289388;294515;314322;25661;246186;361969;83928;80841;24360;304929;308441;24890;29496;65030;116636;24330;116663;140942;25428;65210;25146;25423;497840;113936;170945;25695;81718;114851;29184;313421;246142;79431;25698;155423;25377;25373;50681;50559;24158;25287;170465;312382;25303 zwint;zfp36;zfp354a;usp18;ttr;tsku;trib3;thrsp;tf;sult1e1;stac3;slco1a2;slc37a4;slc1a2;sirt3;serpind1;serpina3c;serpina1;scd;rrs1;rgn;rab30;pzp;ppp1r3b;ppargc1a;por;polg2;plin2;plg;pir;pik3r1;pdia5;pax8;parp1;papss2;nqo1;nfkbib;nfkbia;mt1;mpc2;me1;lpl;loc299282;lama3;kng1;klf6;jun;itpr2;itih4;itih3;itih1;igfbp1;ier2;iars2;hyou1;htra1;hspd1;hspb1;hsd17b7;hsd17b11;hp;hmgcr;hdc;hadh;gstm7;gpx4;gnl3;glul;gdf15;gc;gadd45b;gadd45a;g0s2;foxo3;fos;fn1;fgl1;fga;fetub;fabp7;fabp1;f5;exosc5;esr1;erbb3;ephx2;eif4ebp1;egr1;dusp6;ddit4;cyp7a1;cyp2j4;cyp17a1;ctsc;cps1;cpb2;chrna2;cebpd;cdo1;cdkn1a;cd36;c8b;bmf;bhlhe40;ass1;anxa7;ambp;ahsg;acox1;acot1;acadm;acadl;acaa2;abcg2;abcc2 ZWINT_10214;ZFP36_10204;ZFP354A_10203;USP18_10138;TTR_10102;TSKU_10094;TRIB3_10079;THRSP_33314;TF_10003;SULT1E1_32446;STAC3_9953;SLCO1A2_9886;SLC37A4_9871;SLC1A2_33059;SIRT3_9828;SERPIND1_9812;SERPINA3C_32925;SERPINA1_9807;SCD1_9787;RRS1_9755;RGN_9699;RAB30_9639;PZP_9633;PPP1R3B_9545;PPARGC1A_33189;POR_9531;POLG2_9521;PLIN2_9502;PLG_9501;PIR_9487;PIK3R1_32562;PDIA5_9451;PAX8_9432;PARP1_9425;PAPSS2_33237;NQO1_33055;NFKBIB_9308;NFKBIA_9307;MT1A_9255;MPC2_33219;ME1_9215;LPL_32544;LOC299282_9119;LAMA3_8980;KNG1L1_34113;KLF6_8969;JUN_8938;ITPR2_8931;ITIH4_32725;ITIH3_32422;ITIH1_33132;IGFBP1_32306;IER2_32643;IARS2_8858;HYOU1_8857;HTRA1_8856;HSPD1_8849;HSPB1_8847;HSD17B7_8834;HSD17B11_8832;HP_8823;HMGCR_8810;HDC_8788;HADH_8776;GSTM7_8761;GPX4_32827;GNL3_8735;GLUL_32832;GDF15_33113;GC_32893;GADD45B_8679;GADD45A_8678;G0S2_32729;FOXO3_8662;FOS_8657;FN1_8655;FGL1_8640;FGA_8632;FETUB_33027;FABP7_8592;FABP1_33091;F5_33079;EXOSC5_32543;ESR1_33192;ERBB3_8571;EPHX2_33282;EIF4EBP1_8550;EGR1_8533;DUSP6_8506;DDIT4_8450;CYP7A1_8430;CYP2J4_32580;CYP17A1_32365;CTSC_32456;CPS1_32421;CPB2_8369;CHRNA2_32401;CEBPD_8283;CDO1_8275;CDKN1A_8271;CD36_8243;C8B_8181;BMF_8152;BHLHE40_8141;ASS1_33159;ANXA7_8051;AMBP_33085;AHSG_8003;ACOX1_7973;ACOT1_7968;ACADM_7957;ACADL_32776;ACAA2_7955;ABCG2_32656;ABCC2_32541 41.50470355652175 33.8478 1.28141E-12 29.815982876682465 42.94618055870253 28.326257963764636 28.642193462608716 25.7336 1.28141E-12 20.130295167162032 29.82971922060481 19.661759296180417 67.7240579130435 49.9875 1.28142E-12 57.87135983942572 68.1615377446085 51.17428422779965 93.5 64.35215 52.0003;0.348134;0.834827;108.883;46.6406;1.38416;108.064;32.2053;45.1539;50.1846;63.2393;104.197;39.7166;13.3235;2.38018;28.261;29.766;15.797;105.46;60.39;77.4407;26.4203;34.1871;36.1411;42.4094;12.4414;63.7758;25.6517;70.7857;50.0307;18.7324;107.066;56.8931;26.9741;34.4443;87.2765;30.5572;0.520151;12.9315;46.8463;80.7944;74.2041;45.2017;2.46923;24.3655;18.9476;16.4324;31.8111;57.1163;27.1247;98.1741;49.0259;49.6814;24.7304;40.1982;33.1323;42.2579;89.1011;0.977494;22.4334;64.9285;1.63089;24.5745;33.3125;42.3152;45.9204;87.6357;26.4669;105.149;42.356;106.367;102.919;46.3784;13.1992;1.28141E-12;59.5777;15.4757;28.5803;32.5155;24.601;33.8478;10.6089;41.9329;23.3972;60.9984;38.7293;83.9001;0.750017;62.3934;87.5421;5.72128;17.8395;49.6922;56.2386;31.9826;25.8316;49.3913;0.306936;22.9638;6.24967;48.1296;21.3618;94.8767;57.8085;26.8037;104.64;17.2343;12.402;23.1906;31.2018;11.7137;33.4878;26.5872;5.21654;46.2316 38.9015;0.118102;0.27095;73.1414;28.5876;0.540568;83.8836;24.3966;28.132;36.5009;42.7031;80.3101;22.6911;9.10952;0.56209;22.307;23.347;13.013;63.7532;43.109;58.7732;21.0125;26.3085;27.0588;26.2988;8.48981;40.9553;20.9252;46.2356;38.7717;11.6701;61.3361;45.1162;21.799;25.719;60.6992;24.2439;0.160202;8.91033;35.8494;59.856;49.8682;30.7472;0.871501;19.538;11.6941;10.5224;24.7342;39.6402;21.5108;42.9071;32.6883;33.4626;19.8021;29.3844;25.6145;23.9469;60.3265;0.322682;18.1233;41.6103;0.663137;21.0619;25.7336;31.4035;34.2198;54.41;21.0456;85.3487;26.3722;52.7132;89.5012;33.7914;5.6804;1.28141E-12;31.0499;10.2138;22.529;19.6094;14.4402;26.4736;2.59129;31.7336;18.3088;41.6036;29.2097;42.4185;0.186019;39.0875;53.2453;0.985273;14.6501;35.6654;38.2681;24.4836;20.4374;41.8524;0.0732342;18.5144;2.44025;37.5433;17.2088;73.1342;38.3491;20.9825;43.9254;14.1233;10.3013;16.2815;26.858;8.36151;26.6039;21.3695;2.73368;31.1788 80.8613;1.15962;2.99857;138.144;63.7146;4.10872;143.428;46.6068;61.5341;80.9788;121.52;128.412;60.0334;24.6773;8.82917;38.3264;40.8256;19.9134;422.699;104.942;89.8047;35.3561;48.5666;53.6244;81.7305;79.2355;132.567;33.0375;150.579;73.0083;41.5978;114.259;81.5688;35.2797;51.1014;197.117;41.2611;2.88499;23.4636;69.127;94.0621;155.425;78.6415;10.4175;32.1467;45.5481;39.929;44.3296;101.869;36.4819;104.278;89.1623;89.4404;32.7087;62.3571;46.6629;102.383;106.138;5.49472;29.2247;136.455;7.6286;29.28;46.9856;64.5991;70.4292;238.963;35.4303;125.652;78.7583;109.434;115.437;73.6529;32.7581;1.28142E-12;105.243;30.4106;38.8511;49.9875;35.6155;46.9257;37.5078;62.1373;31.9156;113.972;57.2113;107.32;4.70178;133.304;245.492;22.3625;22.6149;81.6409;102.888;45.5891;34.8042;62.472;1.73689;30.0179;19.0606;69.1421;27.9161;109.848;110.58;36.7081;108.689;21.9073;15.4235;33.4539;37.2719;18.9642;45.3228;35.0407;11.386;81.7848 46 69 46 257644;312688;24856;24825;360268;293615;246074;297784;25106;308821;298199;363465;81819;25591;24314;81525;100359982;24539;364070;63868;289456;24443;113965;81869;29328;290556;299626;289388;80841;24360;308441;29496;65030;116636;65210;25146;170945;29184;246142;155423;50681;50559;24158;25287;170465;312382 ZWINT_10214;USP18_10138;TTR_10102;TF_10003;SULT1E1_32446;SIRT3_9828;SCD1_9787;RRS1_9755;RGN_9699;RAB30_9639;PLIN2_9502;PIR_9487;PAX8_9432;PARP1_9425;NQO1_33055;NFKBIB_9308;MPC2_33219;LPL_32544;IARS2_8858;HSPD1_8849;HSD17B11_8832;HDC_8788;HADH_8776;GSTM7_8761;GPX4_32827;GNL3_8735;GADD45B_8679;G0S2_32729;FABP7_8592;FABP1_33091;EXOSC5_32543;ERBB3_8571;EPHX2_33282;EIF4EBP1_8550;CYP2J4_32580;CYP17A1_32365;CHRNA2_32401;CD36_8243;BMF_8152;ANXA7_8051;ACOX1_7973;ACOT1_7968;ACADM_7957;ACADL_32776;ACAA2_7955;ABCG2_32656 48.46280695652174 45.53715 27.699891838276503 33.47413 31.568550000000002 16.644639911370344 78.89949065217394 64.15685 69.41065546809472 52.0003;108.883;46.6406;45.1539;50.1846;2.38018;105.46;60.39;77.4407;26.4203;25.6517;50.0307;56.8931;26.9741;87.2765;30.5572;46.8463;74.2041;24.7304;42.2579;22.4334;24.5745;33.3125;42.3152;45.9204;87.6357;106.367;46.3784;24.601;33.8478;41.9329;60.9984;38.7293;83.9001;17.8395;49.6922;49.3913;48.1296;94.8767;104.64;23.1906;31.2018;11.7137;33.4878;26.5872;5.21654 38.9015;73.1414;28.5876;28.132;36.5009;0.56209;63.7532;43.109;58.7732;21.0125;20.9252;38.7717;45.1162;21.799;60.6992;24.2439;35.8494;49.8682;19.8021;23.9469;18.1233;21.0619;25.7336;31.4035;34.2198;54.41;52.7132;33.7914;14.4402;26.4736;31.7336;41.6036;29.2097;42.4185;14.6501;35.6654;41.8524;37.5433;73.1342;43.9254;16.2815;26.858;8.36151;26.6039;21.3695;2.73368 80.8613;138.144;63.7146;61.5341;80.9788;8.82917;422.699;104.942;89.8047;35.3561;33.0375;73.0083;81.5688;35.2797;197.117;41.2611;69.127;155.425;32.7087;102.383;29.2247;29.28;46.9856;64.5991;70.4292;238.963;109.434;73.6529;35.6155;46.9257;62.1373;113.972;57.2113;107.32;22.6149;81.6409;62.472;69.1421;109.848;108.689;33.4539;37.2719;18.9642;45.3228;35.0407;11.386 69 79426;24522;308843;246273;25357;362895;170698;29573;29482;79224;24794;24648;252922;192280;83516;29441;303612;85253;25513;360722;294103;25493;24567;24552;299282;307582;288001;58954;24516;81678;54404;50693;306251;25685;494344;192235;65164;24471;29540;24464;25675;24957;29455;24384;25112;294515;314322;25661;246186;361969;83928;304929;24890;24330;116663;140942;25428;25423;497840;113936;25695;81718;114851;313421;79431;25698;25377;25373;25303 ZFP36_10204;ZFP354A_10203;TSKU_10094;TRIB3_10079;THRSP_33314;STAC3_9953;SLCO1A2_9886;SLC37A4_9871;SLC1A2_33059;SERPIND1_9812;SERPINA3C_32925;SERPINA1_9807;PZP_9633;PPP1R3B_9545;PPARGC1A_33189;POR_9531;POLG2_9521;PLG_9501;PIK3R1_32562;PDIA5_9451;PAPSS2_33237;NFKBIA_9307;MT1A_9255;ME1_9215;LOC299282_9119;LAMA3_8980;KNG1L1_34113;KLF6_8969;JUN_8938;ITPR2_8931;ITIH4_32725;ITIH3_32422;ITIH1_33132;IGFBP1_32306;IER2_32643;HYOU1_8857;HTRA1_8856;HSPB1_8847;HSD17B7_8834;HP_8823;HMGCR_8810;GLUL_32832;GDF15_33113;GC_32893;GADD45A_8678;FOXO3_8662;FOS_8657;FN1_8655;FGL1_8640;FGA_8632;FETUB_33027;F5_33079;ESR1_33192;EGR1_8533;DUSP6_8506;DDIT4_8450;CYP7A1_8430;CTSC_32456;CPS1_32421;CPB2_8369;CEBPD_8283;CDO1_8275;CDKN1A_8271;C8B_8181;BHLHE40_8141;ASS1_33159;AMBP_33085;AHSG_8003;ABCC2_32541 36.86596795652174 29.766 30.463471520459148 25.420902437681175 22.529 21.672399136234304 60.27376942028987 45.5481 47.807682605582855 0.348134;0.834827;1.38416;108.064;32.2053;63.2393;104.197;39.7166;13.3235;28.261;29.766;15.797;34.1871;36.1411;42.4094;12.4414;63.7758;70.7857;18.7324;107.066;34.4443;0.520151;12.9315;80.7944;45.2017;2.46923;24.3655;18.9476;16.4324;31.8111;57.1163;27.1247;98.1741;49.0259;49.6814;40.1982;33.1323;89.1011;0.977494;64.9285;1.63089;26.4669;105.149;42.356;102.919;13.1992;1.28141E-12;59.5777;15.4757;28.5803;32.5155;10.6089;23.3972;0.750017;62.3934;87.5421;5.72128;56.2386;31.9826;25.8316;0.306936;22.9638;6.24967;21.3618;57.8085;26.8037;17.2343;12.402;46.2316 0.118102;0.27095;0.540568;83.8836;24.3966;42.7031;80.3101;22.6911;9.10952;22.307;23.347;13.013;26.3085;27.0588;26.2988;8.48981;40.9553;46.2356;11.6701;61.3361;25.719;0.160202;8.91033;59.856;30.7472;0.871501;19.538;11.6941;10.5224;24.7342;39.6402;21.5108;42.9071;32.6883;33.4626;29.3844;25.6145;60.3265;0.322682;41.6103;0.663137;21.0456;85.3487;26.3722;89.5012;5.6804;1.28141E-12;31.0499;10.2138;22.529;19.6094;2.59129;18.3088;0.186019;39.0875;53.2453;0.985273;38.2681;24.4836;20.4374;0.0732342;18.5144;2.44025;17.2088;38.3491;20.9825;14.1233;10.3013;31.1788 1.15962;2.99857;4.10872;143.428;46.6068;121.52;128.412;60.0334;24.6773;38.3264;40.8256;19.9134;48.5666;53.6244;81.7305;79.2355;132.567;150.579;41.5978;114.259;51.1014;2.88499;23.4636;94.0621;78.6415;10.4175;32.1467;45.5481;39.929;44.3296;101.869;36.4819;104.278;89.1623;89.4404;62.3571;46.6629;106.138;5.49472;136.455;7.6286;35.4303;125.652;78.7583;115.437;32.7581;1.28142E-12;105.243;30.4106;38.8511;49.9875;37.5078;31.9156;4.70178;133.304;245.492;22.3625;102.888;45.5891;34.8042;1.73689;30.0179;19.0606;27.9161;110.58;36.7081;21.9073;15.4235;81.7848 0 Exp 2,44(0.39);Exp 3,6(0.06);Exp 4,7(0.07);Hill,10(0.09);Linear,24(0.21);Poly 2,20(0.18);Power,4(0.04) 2.0694118514485944 591.602855682373 1.5074360370635986 344.14306640625 31.930755756670585 1.7576230764389038 36.05520826711799 46.954198845925546 24.96296044381234 32.32142648140508 57.14685493634818 78.30126088973876 DOWN 0.4 0.6 0.0 GO:0071774 4 response to fibroblast growth factor 28 30 4 4 4 3 3 3 159 27 2358 0.8808 0.29728 0.43491 10.0 79426;494344;497840 zfp36;ier2;cps1 ZFP36_10204;IER2_32643;CPS1_32421 27.337378 31.9826 0.348134 24.99252586531925 35.59687459956609 20.74796470404834 19.35476733333333 24.4836 0.118102 17.25377002599726 25.059130215107487 13.84223291417936 45.39637333333334 45.5891 1.15962 44.14070555652835 59.67958065347445 38.97449478766236 0.5 16.165367 2.0 49.6814 0.348134;49.6814;31.9826 0.118102;33.4626;24.4836 1.15962;89.4404;45.5891 0 3 0 3 79426;494344;497840 ZFP36_10204;IER2_32643;CPS1_32421 27.337378 31.9826 24.99252586531925 19.35476733333333 24.4836 17.25377002599726 45.39637333333334 45.5891 44.14070555652835 0.348134;49.6814;31.9826 0.118102;33.4626;24.4836 1.15962;89.4404;45.5891 0 Exp 2,2(0.67);Hill,1(0.34) 1.8417609147479088 5.52944016456604 1.7647881507873535 1.9381765127182007 0.08788815737642502 1.8264755010604858 -0.9443274106986799 55.61908341069868 -0.16971145399567078 38.879246120662344 -4.553537207818714 95.34628387448538 DOWN 0.0 1.0 0.0 GO:0030509 8 BMP signaling pathway 16 16 2 2 2 2 2 2 160 14 2371 0.92323 0.27077 0.27077 12.5 29455;24330 gdf15;egr1 GDF15_33113;EGR1_8533 52.9495085 52.9495085 0.750017 73.8212288282791 55.89597148303632 73.70353137737932 42.7673595 42.7673595 0.186019 60.219109239126745 45.17091439959734 60.123098433489965 65.17689 65.17689 4.70178 85.52472074800478 68.59048020729253 85.38836374364809 0.0 0.750017 0.5 52.9495085 105.149;0.750017 85.3487;0.186019 125.652;4.70178 0 2 0 2 29455;24330 GDF15_33113;EGR1_8533 52.9495085 52.9495085 73.8212288282791 42.7673595 42.7673595 60.219109239126745 65.17689 65.17689 85.52472074800478 105.149;0.750017 85.3487;0.186019 125.652;4.70178 0 Hill,1(0.5);Poly 2,1(0.5) 2.565761397804764 5.778903365135193 1.5606178045272827 4.21828556060791 1.879254892465447 2.8894516825675964 -49.361494839999985 155.26051184 -40.69206787999998 126.22678687999998 -53.354325599999996 183.7081056 DOWN 0.0 1.0 0.0 GO:0007576 8 nucleolar fragmentation 1 1 1 1 1 1 1 1 161 0 2385 1.0 0.063604 0.063604 100.0 24522 zfp354a ZFP354A_10203 0.834827 0.834827 0.834827 0.834827 0.27095 0.27095 0.27095 0.27095 2.99857 2.99857 2.99857 2.99857 0.0 0.834827 0.0 0.834827 0.834827 0.27095 2.99857 0 1 0 1 24522 ZFP354A_10203 0.834827 0.834827 0.27095 0.27095 2.99857 2.99857 0.834827 0.27095 2.99857 0 Hill,1(1) 4.591650485992432 4.591650485992432 4.591650485992432 4.591650485992432 0.0 4.591650485992432 0.834827 0.834827 0.27095 0.27095 2.99857 2.99857 DOWN 0.0 1.0 0.0 GO:0032735 7 positive regulation of interleukin-12 production 14 14 2 2 2 2 2 2 160 12 2373 0.94527 0.22236 0.22236 14.29 63868;29184 hspd1;cd36 HSPD1_8849;CD36_8243 45.19375 45.19375 42.2579 4.151918887092963 45.736904726715935 4.080244641034541 30.7451 30.7451 23.9469 9.61410663972478 32.002819046668 9.448139080226152 85.76255 85.76255 69.1421 23.504865802743858 82.68763950469342 23.09910317083128 0.0 42.2579 0.5 45.19375 42.2579;48.1296 23.9469;37.5433 102.383;69.1421 2 0 2 63868;29184 HSPD1_8849;CD36_8243 45.19375 45.19375 4.151918887092963 30.7451 30.7451 9.61410663972478 85.76255 85.76255 23.504865802743858 42.2579;48.1296 23.9469;37.5433 102.383;69.1421 0 0 Exp 2,1(0.5);Exp 3,1(0.5) 2.4521706396087204 4.922161340713501 2.2518506050109863 2.6703107357025146 0.2958959960681886 2.4610806703567505 39.439484 50.948016 17.420628 44.069572 53.18646800000001 118.33863199999999 UP 1.0 0.0 0.0 GO:0071417 5 cellular response to organonitrogen compound 203 213 32 31 24 27 20 20 142 193 2192 0.97439 0.045799 0.076249 9.39 286954;246273;24825;83516;29441;24651;25513;25591;58954;81678;81869;294515;25661;29496;24330;497840;29184;25698;65054;25373 ugt2b1;trib3;tf;ppargc1a;por;pklr;pik3r1;parp1;klf6;itpr2;gstm7;foxo3;fn1;erbb3;egr1;cps1;cd36;ass1;aqp9;ahsg UGT2B10_33303,UGT2B1_33224;TRIB3_10079;TF_10003;PPARGC1A_33189;POR_9531;PKLR_9489;PIK3R1_32562;PARP1_9425;KLF6_8969;ITPR2_8931;GSTM7_8761;FOXO3_8662;FN1_8655;ERBB3_8571;EGR1_8533;CPS1_32421;CD36_8243;ASS1_33159;AQP9_32709;AHSG_8003 34.94968335 29.771349999999998 0.750017 23.72359530371825 37.363172726564 22.027935240210216 24.70822895 23.2104 0.186019 17.784639861163758 26.120397890330135 15.89281151160249 58.3850815 45.5686 4.70178 34.23607326440471 62.22667747362381 33.29834114831188 9.5 29.771349999999998 47.47345;108.064;45.1539;42.4094;12.4414;23.0963;18.7324;26.9741;18.9476;31.8111;42.3152;13.1992;59.5777;60.9984;0.750017;31.9826;48.1296;26.8037;27.7316;12.402 34.82915;83.8836;28.132;26.2988;8.48981;17.4625;11.6701;21.799;11.6941;24.7342;31.4035;5.6804;31.0499;41.6036;0.186019;24.4836;37.5433;20.9825;21.9372;10.3013 76.47475;143.428;61.5341;81.7305;79.2355;32.9443;41.5978;35.2797;45.5481;44.3296;64.5991;32.7581;105.243;113.972;4.70178;45.5891;69.1421;36.7081;37.4625;15.4235 7 14 6 286954;24825;25591;81869;29496;29184 UGT2B10_33303,UGT2B1_33224;TF_10003;PARP1_9425;GSTM7_8761;ERBB3_8571;CD36_8243 45.17410833333333 46.313675 10.989487507723771 32.55175833333333 33.116325 7.049998741447864 70.16695833333334 66.8706 25.621742053077032 47.47345;45.1539;26.9741;42.3152;60.9984;48.1296 34.82915;28.132;21.799;31.4035;41.6036;37.5433 76.47475;61.5341;35.2797;64.5991;113.972;69.1421 14 246273;83516;29441;24651;25513;58954;81678;294515;25661;24330;497840;25698;65054;25373 TRIB3_10079;PPARGC1A_33189;POR_9531;PKLR_9489;PIK3R1_32562;KLF6_8969;ITPR2_8931;FOXO3_8662;FN1_8655;EGR1_8533;CPS1_32421;ASS1_33159;AQP9_32709;AHSG_8003 30.56778692857143 24.95 26.59305708296621 21.34671635714286 19.2225 20.064779739004813 53.335705714285716 42.9637 37.00090927960259 108.064;42.4094;12.4414;23.0963;18.7324;18.9476;31.8111;13.1992;59.5777;0.750017;31.9826;26.8037;27.7316;12.402 83.8836;26.2988;8.48981;17.4625;11.6701;11.6941;24.7342;5.6804;31.0499;0.186019;24.4836;20.9825;21.9372;10.3013 143.428;81.7305;79.2355;32.9443;41.5978;45.5481;44.3296;32.7581;105.243;4.70178;45.5891;36.7081;37.4625;15.4235 0 Exp 2,9(0.43);Exp 4,1(0.05);Hill,1(0.05);Linear,4(0.2);Poly 2,5(0.24);Power,1(0.05) 1.9849989254445006 43.250797390937805 1.5740432739257812 4.21828556060791 0.6668711330271789 1.8171201944351196 24.552359283117486 45.34700741688252 16.913766867756742 32.502691032243256 43.38046082803308 73.38970217196695 DOWN 0.3 0.7 0.0 GO:0051224 6 negative regulation of protein transport 47 51 8 8 6 7 5 5 157 46 2339 0.89848 0.22108 0.25492 9.8 25591;25675;113965;25661;29184 parp1;hmgcr;hadh;fn1;cd36 PARP1_9425;HMGCR_8810;HADH_8776;FN1_8655;CD36_8243 33.924958 33.3125 1.63089 22.08750430782799 42.16715190377651 16.435629647445833 23.3577874 25.7336 0.663137 13.995703130092961 28.586546024084615 8.615708784142242 52.8558 46.9856 7.6286 36.73738031834877 65.40973373857561 32.31862555203239 1.5 30.1433 26.9741;1.63089;33.3125;59.5777;48.1296 21.799;0.663137;25.7336;31.0499;37.5433 35.2797;7.6286;46.9856;105.243;69.1421 3 2 3 25591;113965;29184 PARP1_9425;HADH_8776;CD36_8243 36.138733333333334 33.3125 10.857232207304659 28.358633333333334 25.7336 8.193829728724737 50.46913333333333 46.9856 17.19787157770791 26.9741;33.3125;48.1296 21.799;25.7336;37.5433 35.2797;46.9856;69.1421 2 25675;25661 HMGCR_8810;FN1_8655 30.604295 30.604295 40.97458229912844 15.8565185 15.8565185 21.48668617560848 56.4358 56.4358 69.02380418145611 1.63089;59.5777 0.663137;31.0499 7.6286;105.243 0 Exp 2,2(0.4);Exp 4,1(0.2);Linear,1(0.2);Power,1(0.2) 2.0012327225994637 10.124139904975891 1.7792335748672485 2.6703107357025146 0.368277531246877 1.9017701148986816 14.564406854435848 53.28550914556415 11.09001271201658 35.62556208798342 20.654066354820436 85.05753364517957 UP 0.6 0.4 0.0 GO:0071313 6 cellular response to caffeine 5 5 2 2 2 2 2 2 160 3 2382 0.9977 0.035397 0.035397 40.0 83516;81869 ppargc1a;gstm7 PPARGC1A_33189;GSTM7_8761 42.3623 42.3623 42.3152 0.0666094587888029 42.36454839138275 0.06653352141135606 28.85115 28.85115 26.2988 3.609567985922957 28.729309623232417 3.605452938283663 73.16480000000001 73.16480000000001 64.5991 12.113729111219131 73.57369694410174 12.0999189897375 0.0 42.3152 0.0 42.3152 42.4094;42.3152 26.2988;31.4035 81.7305;64.5991 1 1 1 81869 GSTM7_8761 42.3152 42.3152 31.4035 31.4035 64.5991 64.5991 42.3152 31.4035 64.5991 1 83516 PPARGC1A_33189 42.4094 42.4094 26.2988 26.2988 81.7305 81.7305 42.4094 26.2988 81.7305 0 Exp 2,1(0.5);Linear,1(0.5) 1.75388391442844 3.5077757835388184 1.7501527070999146 1.7576230764389038 0.005282348817567371 1.7538878917694092 42.269983999999994 42.454616 23.848544 33.853756000000004 56.37602800000002 89.95357200000001 CONFLICT 0.5 0.5 0.0 GO:0051258 8 protein polymerization 20 21 2 2 2 2 2 2 160 19 2366 0.85485 0.39001 0.39001 9.52 29328;361969 gpx4;fga GPX4_32827;FGA_8632 37.25035 37.25035 28.5803 12.261302296452877 33.86862986894932 11.290149330965168 28.3744 28.3744 22.529 8.266643957495685 26.09442389212938 7.611886771036376 54.64015 54.64015 38.8511 22.329088646986914 48.48169090977956 20.56051952342555 0.5 37.25035 45.9204;28.5803 34.2198;22.529 70.4292;38.8511 1 1 1 29328 GPX4_32827 45.9204 45.9204 34.2198 34.2198 70.4292 70.4292 45.9204 34.2198 70.4292 1 361969 FGA_8632 28.5803 28.5803 22.529 22.529 38.8511 38.8511 28.5803 22.529 38.8511 0 Exp 2,1(0.5);Linear,1(0.5) 1.5448397309312591 3.089685082435608 1.541895866394043 1.547789216041565 0.0041672274996661365 1.544842541217804 20.257051999999998 54.24364799999999 16.917416000000003 39.831384 23.693612000000005 85.586688 CONFLICT 0.5 0.5 0.0 GO:0006874 9 cellular calcium ion homeostasis 113 117 12 12 9 10 8 8 154 109 2276 0.67467 0.47027 0.84522 6.84 29573;25106;288001;81678;81869;24890;29184;155423 slc37a4;rgn;kng1;itpr2;gstm7;esr1;cd36;anxa7 SLC37A4_9871;RGN_9699;KNG1L1_34113;ITPR2_8931;GSTM7_8761;ESR1_33192;CD36_8243;ANXA7_8051 48.9769875 41.0159 23.3972 28.269429940052483 51.6369249923639 25.727666618941193 32.1146875 28.06885 18.3088 14.001000143095645 33.883977664998476 12.852552146603896 62.582525000000004 62.316250000000004 31.9156 27.04603348070259 67.18324473344141 22.85821779250585 4.5 45.2224 39.7166;77.4407;24.3655;31.8111;42.3152;23.3972;48.1296;104.64 22.6911;58.7732;19.538;24.7342;31.4035;18.3088;37.5433;43.9254 60.0334;89.8047;32.1467;44.3296;64.5991;31.9156;69.1421;108.689 4 4 4 25106;81869;29184;155423 RGN_9699;GSTM7_8761;CD36_8243;ANXA7_8051 68.131375 62.78515 28.78708695536652 42.91135 40.734350000000006 11.745540362906569 83.058725 79.4734 20.304756272094675 77.4407;42.3152;48.1296;104.64 58.7732;31.4035;37.5433;43.9254 89.8047;64.5991;69.1421;108.689 4 29573;288001;81678;24890 SLC37A4_9871;KNG1L1_34113;ITPR2_8931;ESR1_33192 29.8226 28.0883 7.591905202692311 21.318025 21.11455 2.9314109621761952 42.106325 38.238150000000005 13.283673888744032 39.7166;24.3655;31.8111;23.3972 22.6911;19.538;24.7342;18.3088 60.0334;32.1467;44.3296;31.9156 0 Exp 2,2(0.25);Exp 3,1(0.13);Linear,3(0.38);Poly 2,2(0.25) 1.9708635490134474 16.065009593963623 1.5461770296096802 2.6703107357025146 0.4231145665282101 1.8218688368797302 29.387272001328657 68.56670299867135 22.412489398314783 41.81688560168522 43.84057999516486 81.32447000483513 CONFLICT 0.5 0.5 0.0 GO:0030198 6 extracellular matrix organization 60 68 3 3 3 3 3 3 159 65 2320 0.36173 0.81894 0.79887 4.41 85253;306251;25661 plg;itih1;fn1 PLG_9501;ITIH1_33132;FN1_8655 76.17916666666667 70.7857 59.5777 19.85541828452199 74.82478318114417 19.823744631997098 40.0642 42.9071 31.0499 7.98203804989681 39.33056948021541 8.224752665385926 120.03333333333335 105.243 104.278 26.45772326435766 118.8336034496215 25.839376330055043 70.7857;98.1741;59.5777 46.2356;42.9071;31.0499 150.579;104.278;105.243 0 3 0 3 85253;306251;25661 PLG_9501;ITIH1_33132;FN1_8655 76.17916666666667 70.7857 19.85541828452199 40.0642 42.9071 7.98203804989681 120.03333333333335 105.243 26.45772326435766 70.7857;98.1741;59.5777 46.2356;42.9071;31.0499 150.579;104.278;105.243 0 Exp 3,1(0.34);Linear,1(0.34);Power,1(0.34) 1.6326306625265166 4.908049464225769 1.5254690647125244 1.7792335748672485 0.12999841089395142 1.603346824645996 53.71064572744147 98.64768760589189 31.03167363909211 49.096726360907894 90.09360098164314 149.97306568502356 DOWN 0.0 1.0 0.0 GO:0033559 7 unsaturated fatty acid metabolic process 42 53 15 15 11 12 8 8 154 45 2340 0.99466 0.017089 0.017089 15.09 246074;81869;29328;65030;25315;65210;24894;50681 scd;gstm7;gpx4;ephx2;ephx1;cyp2j4;cyp2a1;acox1 SCD1_9787;GSTM7_8761;GPX4_32827;EPHX2_33282;EPHX1_8567;CYP2J4_32580;CYP2A1_32717;ACOX1_7973 42.665425 40.52225 12.4747 29.37066921421292 37.19439983966962 27.776103329921522 29.40831875 30.306600000000003 7.00435 17.671446046213678 25.866414919227495 17.190415945624412 98.94353749999999 60.90520000000001 22.6149 133.27473908051678 81.84100478561884 119.52679675373615 1.5 20.515050000000002 4.5 44.1178 105.46;42.3152;45.9204;38.7293;12.4747;17.8395;55.3937;23.1906 63.7532;31.4035;34.2198;29.2097;7.00435;14.6501;38.7444;16.2815 422.699;64.5991;70.4292;57.2113;23.684;22.6149;96.8569;33.4539 8 0 8 246074;81869;29328;65030;25315;65210;24894;50681 SCD1_9787;GSTM7_8761;GPX4_32827;EPHX2_33282;EPHX1_8567;CYP2J4_32580;CYP2A1_32717;ACOX1_7973 42.665425 40.52225 29.37066921421292 29.40831875 30.306600000000003 17.671446046213678 98.94353749999999 60.90520000000001 133.27473908051678 105.46;42.3152;45.9204;38.7293;12.4747;17.8395;55.3937;23.1906 63.7532;31.4035;34.2198;29.2097;7.00435;14.6501;38.7444;16.2815 422.699;64.5991;70.4292;57.2113;23.684;22.6149;96.8569;33.4539 0 0 Exp 2,2(0.25);Hill,1(0.13);Linear,4(0.5);Power,1(0.13) 2.674458863938841 24.07705867290497 1.547789216041565 5.973292827606201 1.6263299246685101 2.341066598892212 22.312589618030213 63.01826038196977 17.162631404003104 41.654006095996905 6.588855170592879 191.29821982940717 UP 1.0 0.0 0.0 GO:1904646 7 cellular response to amyloid-beta 23 24 4 4 4 4 4 4 158 20 2365 0.98452 0.061808 0.061808 16.67 25591;294515;25661;29184 parp1;foxo3;fn1;cd36 PARP1_9425;FOXO3_8662;FN1_8655;CD36_8243 36.97015 37.55185 13.1992 20.821573113880397 44.196197648886226 17.45735556870505 24.01815 26.42445 5.6804 13.82718207457085 28.986360747696548 9.825292666946797 60.605725 52.210899999999995 32.7581 34.06979981355678 70.2948882691425 33.684957091317756 0.5 20.08665 1.5 37.55185 26.9741;13.1992;59.5777;48.1296 21.799;5.6804;31.0499;37.5433 35.2797;32.7581;105.243;69.1421 2 2 2 25591;29184 PARP1_9425;CD36_8243 37.55185 37.55185 14.959197509391997 29.67115 29.67115 11.132901295035358 52.210899999999995 52.210899999999995 23.944332667251356 26.9741;48.1296 21.799;37.5433 35.2797;69.1421 2 294515;25661 FOXO3_8662;FN1_8655 36.38845 36.38845 32.7945518512603 18.36515 18.36515 17.93894548531212 69.00055 69.00055 51.25456432362875 13.1992;59.5777 5.6804;31.0499 32.7581;105.243 0 Exp 2,2(0.5);Exp 4,1(0.25);Power,1(0.25) 2.0331117101452505 8.24655532836914 1.7792335748672485 2.6703107357025146 0.41617309213940334 1.8985055088996887 16.565008348397214 57.37529165160278 10.467511566920571 37.56878843307943 27.217321182714365 93.99412881728563 CONFLICT 0.5 0.5 0.0 GO:0043207 4 response to external biotic stimulus 357 390 44 44 37 39 33 33 129 357 2028 0.97165 0.044957 0.071011 8.46 79426;312688;286954;25357;24825;29500;24648;246074;83516;24651;25513;81525;25493;24539;24516;63868;24471;24464;314322;25661;25256;361969;308441;140942;25146;497840;29184;54232;313421;25698;312382;140668;25303 zfp36;usp18;ugt2b1;thrsp;tf;slc10a2;serpina1;scd;ppargc1a;pklr;pik3r1;nfkbib;nfkbia;lpl;jun;hspd1;hspb1;hp;fos;fn1;fmo1;fga;exosc5;ddit4;cyp17a1;cps1;cd36;car3;c8b;ass1;abcg2;abcc3;abcc2 ZFP36_10204;USP18_10138;UGT2B10_33303,UGT2B1_33224;THRSP_33314;TF_10003;SLC10A2_9833;SERPINA1_9807;SCD1_9787;PPARGC1A_33189;PKLR_9489;PIK3R1_32562;NFKBIB_9308;NFKBIA_9307;LPL_32544;JUN_8938;HSPD1_8849;HSPB1_8847;HP_8823;FOS_8657;FN1_8655;FMO1_32787;FGA_8632;EXOSC5_32543;DDIT4_8450;CYP17A1_32365;CPS1_32421;CD36_8243;CAR3_8196;C8B_8181;ASS1_33159;ABCG2_32656;ABCC3_7941;ABCC2_32541 42.9744113636364 42.2579 1.28141E-12 28.328502079743213 45.632416290683125 25.07294950450324 28.676334363636407 28.132 1.28141E-12 17.866006117975015 30.31947506164086 15.792079981388648 79.96588060606064 62.1373 1.28142E-12 79.90229840305489 80.84683025686822 68.30301731334826 18.5 45.692750000000004 0.348134;108.883;47.47345;32.2053;45.1539;56.585;15.797;105.46;42.4094;23.0963;18.7324;30.5572;0.520151;74.2041;16.4324;42.2579;89.1011;64.9285;1.28141E-12;59.5777;65.2792;28.5803;41.9329;87.5421;49.6922;31.9826;48.1296;53.9626;21.3618;26.8037;5.21654;37.7175;46.2316 0.118102;73.1414;34.82915;24.3966;28.132;35.2796;13.013;63.7532;26.2988;17.4625;11.6701;24.2439;0.160202;49.8682;10.5224;23.9469;60.3265;41.6103;1.28141E-12;31.0499;39.7882;22.529;31.7336;53.2453;35.6654;24.4836;37.5433;28.5034;17.2088;20.9825;2.73368;30.9007;31.1788 1.15962;138.144;76.47475;46.6068;61.5341;116.8;19.9134;422.699;81.7305;32.9443;41.5978;41.2611;2.88499;155.425;39.929;102.383;106.138;136.455;1.28142E-12;105.243;82.9415;38.8511;62.1373;245.492;81.6409;45.5891;69.1421;77.0288;27.9161;36.7081;11.386;48.9329;81.7848 14 20 13 312688;286954;24825;246074;81525;24539;63868;25256;308441;25146;29184;312382;140668 USP18_10138;UGT2B10_33303,UGT2B1_33224;TF_10003;SCD1_9787;NFKBIB_9308;LPL_32544;HSPD1_8849;FMO1_32787;EXOSC5_32543;CYP17A1_32365;CD36_8243;ABCG2_32656;ABCC3_7941 53.99673 47.47345 28.646657307960023 36.63689461538461 34.82915 17.914691622847172 104.16166538461539 76.47475 103.03701585178705 108.883;47.47345;45.1539;105.46;30.5572;74.2041;42.2579;65.2792;41.9329;49.6922;48.1296;5.21654;37.7175 73.1414;34.82915;28.132;63.7532;24.2439;49.8682;23.9469;39.7882;31.7336;35.6654;37.5433;2.73368;30.9007 138.144;76.47475;61.5341;422.699;41.2611;155.425;102.383;82.9415;62.1373;81.6409;69.1421;11.386;48.9329 20 79426;25357;29500;24648;83516;24651;25513;25493;24516;24471;24464;314322;25661;361969;140942;497840;54232;313421;25698;25303 ZFP36_10204;THRSP_33314;SLC10A2_9833;SERPINA1_9807;PPARGC1A_33189;PKLR_9489;PIK3R1_32562;NFKBIA_9307;JUN_8938;HSPB1_8847;HP_8823;FOS_8657;FN1_8655;FGA_8632;DDIT4_8450;CPS1_32421;CAR3_8196;C8B_8181;ASS1_33159;ABCC2_32541 35.80990425000006 30.28145 26.384369789289334 23.501970200000066 23.4628 16.228113734794977 64.23862050000005 43.593450000000004 58.193394195870695 0.348134;32.2053;56.585;15.797;42.4094;23.0963;18.7324;0.520151;16.4324;89.1011;64.9285;1.28141E-12;59.5777;28.5803;87.5421;31.9826;53.9626;21.3618;26.8037;46.2316 0.118102;24.3966;35.2796;13.013;26.2988;17.4625;11.6701;0.160202;10.5224;60.3265;41.6103;1.28141E-12;31.0499;22.529;53.2453;24.4836;28.5034;17.2088;20.9825;31.1788 1.15962;46.6068;116.8;19.9134;81.7305;32.9443;41.5978;2.88499;39.929;106.138;136.455;1.28142E-12;105.243;38.8511;245.492;45.5891;77.0288;27.9161;36.7081;81.7848 0 Exp 2,18(0.53);Exp 3,1(0.03);Exp 4,2(0.06);Hill,2(0.06);Linear,3(0.09);Poly 2,6(0.18);Power,2(0.06) 1.9038682968221623 66.49287712574005 1.5074360370635986 3.910295248031616 0.5193568655437478 1.8028545379638672 33.30894725563189 52.639875471640906 22.580592329674193 34.77207639759861 52.703839175566735 107.22792203655456 DOWN 0.3939393939393939 0.6060606060606061 0.0 GO:0030178 7 negative regulation of Wnt signaling pathway 31 31 3 3 3 3 3 3 159 28 2357 0.86955 0.31516 0.44393 9.68 308843;294515;24330 tsku;foxo3;egr1 TSKU_10094;FOXO3_8662;EGR1_8533 5.111125666666666 1.38416 0.750017 7.011650601124983 3.045166692246913 5.7182787856188835 2.1356623333333333 0.540568 0.186019 3.0749471690525563 1.213979584493827 2.517451049357953 13.856200000000001 4.70178 4.10872 16.372211144142987 9.46784568493827 13.100638716302246 0.5 1.0670885 1.38416;13.1992;0.750017 0.540568;5.6804;0.186019 4.10872;32.7581;4.70178 0 3 0 3 308843;294515;24330 TSKU_10094;FOXO3_8662;EGR1_8533 5.111125666666666 1.38416 7.011650601124983 2.1356623333333333 0.540568 3.0749471690525563 13.856200000000001 4.70178 16.372211144142987 1.38416;13.1992;0.750017 0.540568;5.6804;0.186019 4.10872;32.7581;4.70178 0 Exp 4,1(0.34);Hill,2(0.67) 2.9219693242776543 9.181031465530396 1.9883413314819336 4.21828556060791 1.1174533467062975 2.9744045734405518 -2.8233039228986296 13.045555256231962 -1.3439679552275545 5.61529262189422 -4.670701002148682 32.383101002148685 DOWN 0.0 1.0 0.0 GO:0071229 5 cellular response to acid chemical 95 99 15 15 11 12 8 8 154 91 2294 0.82559 0.29209 0.40572 8.08 83516;25513;24539;24471;25661;24330;497840;25698 ppargc1a;pik3r1;lpl;hspb1;fn1;egr1;cps1;ass1 PPARGC1A_33189;PIK3R1_32562;LPL_32544;HSPB1_8847;FN1_8655;EGR1_8533;CPS1_32421;ASS1_33159 42.945127125 37.196 0.750017 29.596893768292166 47.930008430176585 29.67680403300517 28.108202375 25.391199999999998 0.186019 19.409926146899743 30.87644937995896 19.449080138900204 72.14166 63.659800000000004 4.70178 48.874695223358984 81.33005035875215 51.159101505222885 3.5 37.196 42.4094;18.7324;74.2041;89.1011;59.5777;0.750017;31.9826;26.8037 26.2988;11.6701;49.8682;60.3265;31.0499;0.186019;24.4836;20.9825 81.7305;41.5978;155.425;106.138;105.243;4.70178;45.5891;36.7081 1 7 1 24539 LPL_32544 74.2041 74.2041 49.8682 49.8682 155.425 155.425 74.2041 49.8682 155.425 7 83516;25513;24471;25661;24330;497840;25698 PPARGC1A_33189;PIK3R1_32562;HSPB1_8847;FN1_8655;EGR1_8533;CPS1_32421;ASS1_33159 38.47955957142857 31.9826 28.911129359044565 24.999631285714287 24.4836 18.690802707199378 60.244040000000005 45.5891 38.284380146101334 42.4094;18.7324;89.1011;59.5777;0.750017;31.9826;26.8037 26.2988;11.6701;60.3265;31.0499;0.186019;24.4836;20.9825 81.7305;41.5978;106.138;105.243;4.70178;45.5891;36.7081 0 Exp 2,4(0.5);Hill,1(0.13);Poly 2,2(0.25);Power,1(0.13) 1.9401952228409944 16.393344283103943 1.559399127960205 4.21828556060791 0.8819945451249709 1.7684283256530762 22.435526125095087 63.454728124904925 14.657809782213176 41.558594967786824 38.273224147554366 106.01009585244563 DOWN 0.125 0.875 0.0 GO:0051094 5 positive regulation of developmental process 376 396 28 28 23 25 20 20 142 376 2009 0.14605 0.90164 0.26451 5.05 79426;24825;360268;83516;29441;25513;81819;25591;24539;24516;24471;25675;29455;294515;314322;25661;29496;24330;25695;29184 zfp36;tf;sult1e1;ppargc1a;por;pik3r1;pax8;parp1;lpl;jun;hspb1;hmgcr;gdf15;foxo3;fos;fn1;erbb3;egr1;cebpd;cd36 ZFP36_10204;TF_10003;SULT1E1_32446;PPARGC1A_33189;POR_9531;PIK3R1_32562;PAX8_9432;PARP1_9425;LPL_32544;JUN_8938;HSPB1_8847;HMGCR_8810;GDF15_33113;FOXO3_8662;FOS_8657;FN1_8655;ERBB3_8571;EGR1_8533;CEBPD_8283;CD36_8243 36.13081885000007 34.69175 1.28141E-12 31.832898653959642 44.96637066904223 30.92322003155127 25.049515110000065 24.0489 1.28141E-12 23.66786089399588 31.316532498150824 23.132747546461623 61.270564500000056 65.3381 1.28142E-12 46.259030972461304 74.37679998896135 45.11990457448293 18.5 97.12505 0.348134;45.1539;50.1846;42.4094;12.4414;18.7324;56.8931;26.9741;74.2041;16.4324;89.1011;1.63089;105.149;13.1992;1.28141E-12;59.5777;60.9984;0.750017;0.306936;48.1296 0.118102;28.132;36.5009;26.2988;8.48981;11.6701;45.1162;21.799;49.8682;10.5224;60.3265;0.663137;85.3487;5.6804;1.28141E-12;31.0499;41.6036;0.186019;0.0732342;37.5433 1.15962;61.5341;80.9788;81.7305;79.2355;41.5978;81.5688;35.2797;155.425;39.929;106.138;7.6286;125.652;32.7581;1.28142E-12;105.243;113.972;4.70178;1.73689;69.1421 7 13 7 24825;360268;81819;25591;24539;29496;29184 TF_10003;SULT1E1_32446;PAX8_9432;PARP1_9425;LPL_32544;ERBB3_8571;CD36_8243 51.791114285714286 50.1846 14.657595776186989 37.22331428571429 37.5433 9.68300420365991 85.41435714285714 80.9788 38.94446566650421 45.1539;50.1846;56.8931;26.9741;74.2041;60.9984;48.1296 28.132;36.5009;45.1162;21.799;49.8682;41.6036;37.5433 61.5341;80.9788;81.5688;35.2797;155.425;113.972;69.1421 13 79426;83516;29441;25513;24516;24471;25675;29455;294515;314322;25661;24330;25695 ZFP36_10204;PPARGC1A_33189;POR_9531;PIK3R1_32562;JUN_8938;HSPB1_8847;HMGCR_8810;GDF15_33113;FOXO3_8662;FOS_8657;FN1_8655;EGR1_8533;CEBPD_8283 27.69835207692317 13.1992 35.73416455293976 18.494392476923174 8.48981 26.59042245192107 48.27006076923087 39.929 45.89880465114421 0.348134;42.4094;12.4414;18.7324;16.4324;89.1011;1.63089;105.149;13.1992;1.28141E-12;59.5777;0.750017;0.306936 0.118102;26.2988;8.48981;11.6701;10.5224;60.3265;0.663137;85.3487;5.6804;1.28141E-12;31.0499;0.186019;0.0732342 1.15962;81.7305;79.2355;41.5978;39.929;106.138;7.6286;125.652;32.7581;1.28142E-12;105.243;4.70178;1.73689 0 Exp 2,6(0.3);Exp 4,2(0.1);Hill,4(0.2);Linear,1(0.05);Poly 2,6(0.3);Power,1(0.05) 1.8932310540360082 38.96627163887024 1.559399127960205 4.21828556060791 0.5860247796405151 1.7939516305923462 22.179435889021462 50.08220181097866 14.676617725167254 35.42241249483288 40.9966502857725 81.54447871422764 DOWN 0.35 0.65 0.0 GO:0051345 6 positive regulation of hydrolase activity 168 180 11 11 8 9 6 6 156 174 2211 0.050054 0.97853 0.11048 3.33 25106;24516;63868;25661;24360;24890 rgn;jun;hspd1;fn1;fabp1;esr1 RGN_9699;JUN_8938;HSPD1_8849;FN1_8655;FABP1_33091;ESR1_33192 42.158950000000004 38.05285 16.4324 22.939740094495402 48.03218872152255 20.965529459392 28.179133333333336 25.210250000000002 10.5224 16.578555856969775 30.449220763148844 15.232405496026503 69.36683333333333 68.3652 31.9156 33.36962200796808 81.0237963936373 30.93882151141045 77.4407;16.4324;42.2579;59.5777;33.8478;23.3972 58.7732;10.5224;23.9469;31.0499;26.4736;18.3088 89.8047;39.929;102.383;105.243;46.9257;31.9156 3 3 3 25106;63868;24360 RGN_9699;HSPD1_8849;FABP1_33091 51.18213333333333 42.2579 23.126104039447146 36.3979 26.4736 19.418717537211357 79.70446666666668 89.8047 29.075575073647812 77.4407;42.2579;33.8478 58.7732;23.9469;26.4736 89.8047;102.383;46.9257 3 24516;25661;24890 JUN_8938;FN1_8655;ESR1_33192 33.13576666666666 23.3972 23.16266367591028 19.96036666666667 18.3088 10.36293001053917 59.0292 39.929 40.2223834166997 16.4324;59.5777;23.3972 10.5224;31.0499;18.3088 39.929;105.243;31.9156 0 Exp 2,2(0.34);Exp 3,1(0.17);Poly 2,2(0.34);Power,1(0.17) 1.991088467294967 12.041805267333984 1.7198865413665771 2.436986207962036 0.2818855267732934 1.9269241690635681 23.803335032564355 60.51456496743565 14.913525842876892 41.44474082378978 42.66557470250394 96.06809196416273 CONFLICT 0.5 0.5 0.0 GO:0051726 5 regulation of cell cycle 252 268 11 11 8 8 6 6 156 262 2123 9.9232E-4 0.99971 0.0020675 2.24 257644;24516;299626;25112;116636;114851 zwint;jun;gadd45b;gadd45a;eif4ebp1;cdkn1a ZWINT_10214;JUN_8938;GADD45B_8679;GADD45A_8678;EIF4EBP1_8550;CDKN1A_8271 61.311411666666665 67.9502 6.24967 43.3683390772856 59.0235910671766 45.997967325518566 39.416175 40.66 2.44025 31.29430846725567 41.07493685460489 37.436939611829615 78.67365 94.09065 19.0606 40.44256631351428 75.71251022453889 45.61204531582147 52.0003;16.4324;106.367;102.919;83.9001;6.24967 38.9015;10.5224;52.7132;89.5012;42.4185;2.44025 80.8613;39.929;109.434;115.437;107.32;19.0606 3 3 3 257644;299626;116636 ZWINT_10214;GADD45B_8679;EIF4EBP1_8550 80.75580000000001 83.9001 27.31939757919267 44.67773333333333 42.4185 7.177664359896828 99.2051 107.32 15.921322113128719 52.0003;106.367;83.9001 38.9015;52.7132;42.4185 80.8613;109.434;107.32 3 24516;25112;114851 JUN_8938;GADD45A_8678;CDKN1A_8271 41.86702333333333 16.4324 53.11713366460612 34.15461666666666 10.5224 48.10159563009145 58.1422 39.929 50.70397528715081 16.4324;102.919;6.24967 10.5224;89.5012;2.44025 39.929;115.437;19.0606 0 Exp 2,1(0.17);Exp 3,1(0.17);Exp 4,1(0.17);Poly 2,2(0.34);Power,1(0.17) 1.6397357035508022 9.880932450294495 1.5207922458648682 1.9785058498382568 0.17386862839115724 1.5933386087417603 26.609513101091046 96.0133102322423 14.375513051308396 64.4568369486916 46.3128572234513 111.03444277654869 CONFLICT 0.5 0.5 0.0 GO:0032787 7 monocarboxylic acid metabolic process 180 207 64 64 45 57 38 38 124 169 2216 1.0 3.8323E-10 3.8323E-10 18.36 286954;29573;65192;29500;246074;501907;83516;29441;24651;100359982;24552;24539;171155;113965;85255;81869;29328;295143;65030;25315;171142;291075;29740;25428;65210;24894;83842;29184;25284;65183;50681;192272;170570;50559;24158;25287;170465;25303 ugt2b1;slc37a4;slc27a2;slc10a2;scd;rgd1559459;ppargc1a;por;pklr;mpc2;me1;lpl;hadhb;hadh;hacl1;gstm7;gpx4;etfdh;ephx2;ephx1;ehhadh;eci2;eci1;cyp7a1;cyp2j4;cyp2a1;crot;cd36;amacr;aldh3a2;acox1;acot2;acot12;acot1;acadm;acadl;acaa2;abcc2 UGT2B10_33303,UGT2B1_33224;SLC37A4_9871;SLC27A2_9860;SLC10A2_9833;SCD1_9787;RGD1559459_9690;PPARGC1A_33189;POR_9531;PKLR_9489;MPC2_33219;ME1_9215;LPL_32544;HADHB_8777;HADH_8776;HACL1_8775;GSTM7_8761;GPX4_32827;ETFDH_8575;EPHX2_33282;EPHX1_8567;EHHADH_8534;ECI2_8521;ECI1_8520;CYP7A1_8430;CYP2J4_32580;CYP2A1_32717;CROT_8384;CD36_8243;AMACR_8038;ALDH3A2_8024;ACOX1_7973;ACOT2_7969;ACOT12_32718;ACOT1_7968;ACADM_7957;ACADL_32776;ACAA2_7955;ABCC2_32541 31.556136842105268 30.77205 2.52378E-13 23.246827556132985 32.428703092206106 21.298590921115043 22.501868236842117 23.3534 2.52378E-13 15.729903217342475 23.285930758574242 14.252623140222427 58.02061210526316 41.62545 2.52379E-13 69.69379206081628 58.74772258591205 63.507168805113146 9.5 12.19435 19.5 31.50235 47.47345;39.7166;7.62189;56.585;105.46;2.52378E-13;42.4094;12.4414;23.0963;46.8463;80.7944;74.2041;31.8029;33.3125;17.6275;42.3152;45.9204;18.1231;38.7293;12.4747;8.62809;10.6467;11.9473;5.72128;17.8395;55.3937;7.4229;48.1296;2.03774;43.1079;23.1906;8.54905;30.3423;31.2018;11.7137;33.4878;26.5872;46.2316 34.82915;22.6911;5.49916;35.2796;63.7532;2.52378E-13;26.2988;8.48981;17.4625;35.8494;59.856;49.8682;25.5756;25.7336;11.195;31.4035;34.2198;14.869;29.2097;7.00435;7.31865;8.92359;7.15307;0.985273;14.6501;38.7444;5.75707;37.5433;1.165;31.8774;16.2815;7.19676;24.0157;26.858;8.36151;26.6039;21.3695;31.1788 76.47475;60.0334;13.3925;116.8;422.699;2.52379E-13;81.7305;79.2355;32.9443;69.127;94.0621;155.425;42.1484;46.9856;37.6534;64.5991;70.4292;23.0103;57.2113;23.684;10.3909;13.0581;19.001;22.3625;22.6149;96.8569;10.316;69.1421;3.73641;66.3058;33.4539;10.4125;41.1025;37.2719;18.9642;45.3228;35.0407;81.7848 30 9 29 286954;65192;246074;100359982;24539;171155;113965;85255;81869;29328;295143;65030;25315;171142;291075;29740;65210;24894;83842;29184;25284;65183;50681;192272;170570;50559;24158;25287;170465 UGT2B10_33303,UGT2B1_33224;SLC27A2_9860;SCD1_9787;MPC2_33219;LPL_32544;HADHB_8777;HADH_8776;HACL1_8775;GSTM7_8761;GPX4_32827;ETFDH_8575;EPHX2_33282;EPHX1_8567;EHHADH_8534;ECI2_8521;ECI1_8520;CYP2J4_32580;CYP2A1_32717;CROT_8384;CD36_8243;AMACR_8038;ALDH3A2_8024;ACOX1_7973;ACOT2_7969;ACOT12_32718;ACOT1_7968;ACADM_7957;ACADL_32776;ACAA2_7955 30.7633524137931 30.3423 22.698607668258866 22.51134862068966 24.0157 15.01847416025645 56.40793655172415 37.6534 77.46892323121618 47.47345;7.62189;105.46;46.8463;74.2041;31.8029;33.3125;17.6275;42.3152;45.9204;18.1231;38.7293;12.4747;8.62809;10.6467;11.9473;17.8395;55.3937;7.4229;48.1296;2.03774;43.1079;23.1906;8.54905;30.3423;31.2018;11.7137;33.4878;26.5872 34.82915;5.49916;63.7532;35.8494;49.8682;25.5756;25.7336;11.195;31.4035;34.2198;14.869;29.2097;7.00435;7.31865;8.92359;7.15307;14.6501;38.7444;5.75707;37.5433;1.165;31.8774;16.2815;7.19676;24.0157;26.858;8.36151;26.6039;21.3695 76.47475;13.3925;422.699;69.127;155.425;42.1484;46.9856;37.6534;64.5991;70.4292;23.0103;57.2113;23.684;10.3909;13.0581;19.001;22.6149;96.8569;10.316;69.1421;3.73641;66.3058;33.4539;10.4125;41.1025;37.2719;18.9642;45.3228;35.0407 9 29573;29500;501907;83516;29441;24651;24552;25428;25303 SLC37A4_9871;SLC10A2_9833;RGD1559459_9690;PPARGC1A_33189;POR_9531;PKLR_9489;ME1_9215;CYP7A1_8430;ABCC2_32541 34.110664444444474 39.7166 26.201257965398828 22.471320333333363 22.6911 18.839339782457532 63.21701111111114 79.2355 37.6807547659426 39.7166;56.585;2.52378E-13;42.4094;12.4414;23.0963;80.7944;5.72128;46.2316 22.6911;35.2796;2.52378E-13;26.2988;8.48981;17.4625;59.856;0.985273;31.1788 60.0334;116.8;2.52379E-13;81.7305;79.2355;32.9443;94.0621;22.3625;81.7848 0 Exp 2,17(0.44);Exp 4,1(0.03);Hill,5(0.13);Linear,9(0.24);Poly 2,6(0.16);Power,1(0.03) 2.928435216512459 484.9370082616806 1.520427942276001 344.14306640625 54.7775923903808 1.9641557931900024 24.16471537234744 38.94755831186309 17.500482818675472 27.503253655008756 35.86119316075212 80.18003104977421 UP 0.7631578947368421 0.23684210526315788 0.0 GO:0015711 6 organic anion transport 106 111 27 26 19 25 17 17 145 94 2291 0.99985 4.7333E-4 4.7333E-4 15.32 170698;29573;25351;65192;361074;29482;29500;298199;100359982;24360;25428;83842;29184;65054;312382;140668;25303 slco1a2;slc37a4;slc2a2;slc27a2;slc25a30;slc1a2;slc10a2;plin2;mpc2;fabp1;cyp7a1;crot;cd36;aqp9;abcg2;abcc3;abcc2 SLCO1A2_9886;SLC37A4_9871;SLC2A2_9863;SLC27A2_9860;SLC25A30_9856;SLC1A2_33059;SLC10A2_9833;PLIN2_9502;MPC2_33219;FABP1_33091;CYP7A1_8430;CROT_8384;CD36_8243;AQP9_32709;ABCG2_32656;ABCC3_7941;ABCC2_32541 34.631135882352936 33.8478 5.21654 24.92246976308254 32.913710825466865 20.617954523212408 25.176117823529413 23.3399 0.985273 19.006528297577503 23.585880314164463 15.324599113770944 53.22703529411765 46.9257 10.316 35.57449100491356 51.88509439280503 32.67184627130975 4.5 19.4876 10.5 42.9741 104.197;39.7166;29.7555;7.62189;53.013;13.3235;56.585;25.6517;46.8463;33.8478;5.72128;7.4229;48.1296;27.7316;5.21654;37.7175;46.2316 80.3101;22.6911;23.3399;5.49916;37.4804;9.10952;35.2796;20.9252;35.8494;26.4736;0.985273;5.75707;37.5433;21.9372;2.73368;30.9007;31.1788 128.412;60.0334;40.808;13.3925;90.2594;24.6773;116.8;33.0375;69.127;46.9257;22.3625;10.316;69.1421;37.4625;11.386;48.9329;81.7848 9 8 9 65192;361074;298199;100359982;24360;83842;29184;312382;140668 SLC27A2_9860;SLC25A30_9856;PLIN2_9502;MPC2_33219;FABP1_33091;CROT_8384;CD36_8243;ABCG2_32656;ABCC3_7941 29.496358888888892 33.8478 18.90037606988445 22.573612222222224 26.4736 14.481772574082374 43.61323333333333 46.9257 28.91852920507888 7.62189;53.013;25.6517;46.8463;33.8478;7.4229;48.1296;5.21654;37.7175 5.49916;37.4804;20.9252;35.8494;26.4736;5.75707;37.5433;2.73368;30.9007 13.3925;90.2594;33.0375;69.127;46.9257;10.316;69.1421;11.386;48.9329 8 170698;29573;25351;29482;29500;25428;65054;25303 SLCO1A2_9886;SLC37A4_9871;SLC2A2_9863;SLC1A2_33059;SLC10A2_9833;CYP7A1_8430;AQP9_32709;ABCC2_32541 40.407759999999996 34.73605 30.65016839449804 28.103936625 23.0155 23.822743303732736 64.0425625 50.4207 41.041491531408525 104.197;39.7166;29.7555;13.3235;56.585;5.72128;27.7316;46.2316 80.3101;22.6911;23.3399;9.10952;35.2796;0.985273;21.9372;31.1788 128.412;60.0334;40.808;24.6773;116.8;22.3625;37.4625;81.7848 0 Exp 2,7(0.42);Exp 4,1(0.06);Hill,2(0.12);Linear,3(0.18);Poly 2,4(0.24) 2.253265659387251 41.75697195529938 1.5074360370635986 5.963563919067383 1.2230271644087463 1.893584966659546 22.783745790733818 46.47852597397208 16.140987791498944 34.21124785555988 36.315995728114466 70.13807486012084 CONFLICT 0.5294117647058824 0.47058823529411764 0.0 GO:0048583 4 regulation of response to stimulus 781 832 67 66 54 59 49 49 113 783 1602 0.27895 0.77673 0.54487 5.89 79426;312688;308843;246273;24825;293615;297784;25106;83516;29441;85253;25513;25591;25493;100359982;24539;288001;24516;25685;192235;65164;63868;24471;25675;81869;29328;29455;299626;25112;289388;294515;25661;246186;361969;80841;24890;29496;24330;116663;140942;65210;25423;113936;114851;29184;313421;246142;25373;170465 zfp36;usp18;tsku;trib3;tf;sirt3;rrs1;rgn;ppargc1a;por;plg;pik3r1;parp1;nfkbia;mpc2;lpl;kng1;jun;igfbp1;hyou1;htra1;hspd1;hspb1;hmgcr;gstm7;gpx4;gdf15;gadd45b;gadd45a;g0s2;foxo3;fn1;fgl1;fga;fabp7;esr1;erbb3;egr1;dusp6;ddit4;cyp2j4;ctsc;cpb2;cdkn1a;cd36;c8b;bmf;ahsg;acaa2 ZFP36_10204;USP18_10138;TSKU_10094;TRIB3_10079;TF_10003;SIRT3_9828;RRS1_9755;RGN_9699;PPARGC1A_33189;POR_9531;PLG_9501;PIK3R1_32562;PARP1_9425;NFKBIA_9307;MPC2_33219;LPL_32544;KNG1L1_34113;JUN_8938;IGFBP1_32306;HYOU1_8857;HTRA1_8856;HSPD1_8849;HSPB1_8847;HMGCR_8810;GSTM7_8761;GPX4_32827;GDF15_33113;GADD45B_8679;GADD45A_8678;G0S2_32729;FOXO3_8662;FN1_8655;FGL1_8640;FGA_8632;FABP7_8592;ESR1_33192;ERBB3_8571;EGR1_8533;DUSP6_8506;DDIT4_8450;CYP2J4_32580;CTSC_32456;CPB2_8369;CDKN1A_8271;CD36_8243;C8B_8181;BMF_8152;AHSG_8003;ACAA2_7955 43.432295959183676 42.2579 0.348134 32.68847138134548 47.21188298578436 31.89687587845189 30.407968938775507 26.2988 0.118102 23.76091713614519 33.671253947829776 24.40426357671206 69.84537510204083 64.5991 1.15962 51.01188824046225 74.73941893394729 46.73470280714255 40.5 82.4914 0.348134;108.883;1.38416;108.064;45.1539;2.38018;60.39;77.4407;42.4094;12.4414;70.7857;18.7324;26.9741;0.520151;46.8463;74.2041;24.3655;16.4324;49.0259;40.1982;33.1323;42.2579;89.1011;1.63089;42.3152;45.9204;105.149;106.367;102.919;46.3784;13.1992;59.5777;15.4757;28.5803;24.601;23.3972;60.9984;0.750017;62.3934;87.5421;17.8395;56.2386;25.8316;6.24967;48.1296;21.3618;94.8767;12.402;26.5872 0.118102;73.1414;0.540568;83.8836;28.132;0.56209;43.109;58.7732;26.2988;8.48981;46.2356;11.6701;21.799;0.160202;35.8494;49.8682;19.538;10.5224;32.6883;29.3844;25.6145;23.9469;60.3265;0.663137;31.4035;34.2198;85.3487;52.7132;89.5012;33.7914;5.6804;31.0499;10.2138;22.529;14.4402;18.3088;41.6036;0.186019;39.0875;53.2453;14.6501;38.2681;20.4374;2.44025;37.5433;17.2088;73.1342;10.3013;21.3695 1.15962;138.144;4.10872;143.428;61.5341;8.82917;104.942;89.8047;81.7305;79.2355;150.579;41.5978;35.2797;2.88499;69.127;155.425;32.1467;39.929;89.1623;62.3571;46.6629;102.383;106.138;7.6286;64.5991;70.4292;125.652;109.434;115.437;73.6529;32.7581;105.243;30.4106;38.8511;35.6155;31.9156;113.972;4.70178;133.304;245.492;22.6149;102.888;34.8042;19.0606;69.1421;27.9161;109.848;15.4235;35.0407 19 30 19 312688;24825;293615;297784;25106;25591;100359982;24539;63868;81869;29328;299626;289388;80841;29496;65210;29184;246142;170465 USP18_10138;TF_10003;SIRT3_9828;RRS1_9755;RGN_9699;PARP1_9425;MPC2_33219;LPL_32544;HSPD1_8849;GSTM7_8761;GPX4_32827;GADD45B_8679;G0S2_32729;FABP7_8592;ERBB3_8571;CYP2J4_32580;CD36_8243;BMF_8152;ACAA2_7955 52.5549252631579 46.3784 29.167310966032456 36.31842052631578 34.2198 19.234938378808536 77.35879315789474 70.4292 39.69568264505599 108.883;45.1539;2.38018;60.39;77.4407;26.9741;46.8463;74.2041;42.2579;42.3152;45.9204;106.367;46.3784;24.601;60.9984;17.8395;48.1296;94.8767;26.5872 73.1414;28.132;0.56209;43.109;58.7732;21.799;35.8494;49.8682;23.9469;31.4035;34.2198;52.7132;33.7914;14.4402;41.6036;14.6501;37.5433;73.1342;21.3695 138.144;61.5341;8.82917;104.942;89.8047;35.2797;69.127;155.425;102.383;64.5991;70.4292;109.434;73.6529;35.6155;113.972;22.6149;69.1421;109.848;35.0407 30 79426;308843;246273;83516;29441;85253;25513;25493;288001;24516;25685;192235;65164;24471;25675;29455;25112;294515;25661;246186;361969;24890;24330;116663;140942;25423;113936;114851;313421;25373 ZFP36_10204;TSKU_10094;TRIB3_10079;PPARGC1A_33189;POR_9531;PLG_9501;PIK3R1_32562;NFKBIA_9307;KNG1L1_34113;JUN_8938;IGFBP1_32306;HYOU1_8857;HTRA1_8856;HSPB1_8847;HMGCR_8810;GDF15_33113;GADD45A_8678;FOXO3_8662;FN1_8655;FGL1_8640;FGA_8632;ESR1_33192;EGR1_8533;DUSP6_8506;DDIT4_8450;CTSC_32456;CPB2_8369;CDKN1A_8271;C8B_8181;AHSG_8003 37.654630733333335 25.098550000000003 33.93395807647906 26.66468293333333 19.9877 25.83509000165688 65.08687699999999 40.763400000000004 57.17211912286034 0.348134;1.38416;108.064;42.4094;12.4414;70.7857;18.7324;0.520151;24.3655;16.4324;49.0259;40.1982;33.1323;89.1011;1.63089;105.149;102.919;13.1992;59.5777;15.4757;28.5803;23.3972;0.750017;62.3934;87.5421;56.2386;25.8316;6.24967;21.3618;12.402 0.118102;0.540568;83.8836;26.2988;8.48981;46.2356;11.6701;0.160202;19.538;10.5224;32.6883;29.3844;25.6145;60.3265;0.663137;85.3487;89.5012;5.6804;31.0499;10.2138;22.529;18.3088;0.186019;39.0875;53.2453;38.2681;20.4374;2.44025;17.2088;10.3013 1.15962;4.10872;143.428;81.7305;79.2355;150.579;41.5978;2.88499;32.1467;39.929;89.1623;62.3571;46.6629;106.138;7.6286;125.652;115.437;32.7581;105.243;30.4106;38.8511;31.9156;4.70178;133.304;245.492;102.888;34.8042;19.0606;27.9161;15.4235 0 Exp 2,16(0.33);Exp 3,1(0.03);Exp 4,4(0.09);Hill,5(0.11);Linear,9(0.19);Poly 2,11(0.23);Power,3(0.07) 1.932746105566356 98.5733870267868 1.511321783065796 4.21828556060791 0.658981622899082 1.7576230764389038 34.279523972406935 52.585067945960404 23.754912140654866 37.06102573689617 55.56204639471139 84.12870380937025 DOWN 0.3877551020408163 0.6122448979591837 0.0 GO:0032270 7 positive regulation of cellular protein metabolic process 403 428 29 29 24 25 20 20 142 408 1977 0.068414 0.95748 0.1286 4.67 246273;24825;25106;25513;25493;24516;63868;25675;290556;29455;299626;25112;25661;361969;24890;29496;24330;25423;114851;29184 trib3;tf;rgn;pik3r1;nfkbia;jun;hspd1;hmgcr;gnl3;gdf15;gadd45b;gadd45a;fn1;fga;esr1;erbb3;egr1;ctsc;cdkn1a;cd36 TRIB3_10079;TF_10003;RGN_9699;PIK3R1_32562;NFKBIA_9307;JUN_8938;HSPD1_8849;HMGCR_8810;GNL3_8735;GDF15_33113;GADD45B_8679;GADD45A_8678;FN1_8655;FGA_8632;ESR1_33192;ERBB3_8571;EGR1_8533;CTSC_32456;CDKN1A_8271;CD36_8243 49.811226399999995 46.64175 0.520151 37.90306388632299 51.992439120787196 34.629319119777236 34.5826804 29.59095 0.160202 28.68651595343006 37.27392440252358 28.55777164124619 78.22251849999999 79.4734 2.88499 58.246353872266084 78.21659868821051 44.98128732528058 108.064;45.1539;77.4407;18.7324;0.520151;16.4324;42.2579;1.63089;87.6357;105.149;106.367;102.919;59.5777;28.5803;23.3972;60.9984;0.750017;56.2386;6.24967;48.1296 83.8836;28.132;58.7732;11.6701;0.160202;10.5224;23.9469;0.663137;54.41;85.3487;52.7132;89.5012;31.0499;22.529;18.3088;41.6036;0.186019;38.2681;2.44025;37.5433 143.428;61.5341;89.8047;41.5978;2.88499;39.929;102.383;7.6286;238.963;125.652;109.434;115.437;105.243;38.8511;31.9156;113.972;4.70178;102.888;19.0606;69.1421 7 13 7 24825;25106;63868;290556;299626;29496;29184 TF_10003;RGN_9699;HSPD1_8849;GNL3_8735;GADD45B_8679;ERBB3_8571;CD36_8243 66.85474285714285 60.9984 24.37891205822887 42.44602857142858 41.6036 13.45971491485043 112.17612857142856 102.383 59.29949978203061 45.1539;77.4407;42.2579;87.6357;106.367;60.9984;48.1296 28.132;58.7732;23.9469;54.41;52.7132;41.6036;37.5433 61.5341;89.8047;102.383;238.963;109.434;113.972;69.1421 13 246273;25513;25493;24516;25675;29455;25112;25661;361969;24890;24330;25423;114851 TRIB3_10079;PIK3R1_32562;NFKBIA_9307;JUN_8938;HMGCR_8810;GDF15_33113;GADD45A_8678;FN1_8655;FGA_8632;ESR1_33192;EGR1_8533;CTSC_32456;CDKN1A_8271 40.63394830769231 23.3972 41.43464016237436 30.348569846153847 18.3088 34.01291236455038 59.93980538461539 39.929 50.78242048116168 108.064;18.7324;0.520151;16.4324;1.63089;105.149;102.919;59.5777;28.5803;23.3972;0.750017;56.2386;6.24967 83.8836;11.6701;0.160202;10.5224;0.663137;85.3487;89.5012;31.0499;22.529;18.3088;0.186019;38.2681;2.44025 143.428;41.5978;2.88499;39.929;7.6286;125.652;115.437;105.243;38.8511;31.9156;4.70178;102.888;19.0606 0 Exp 2,4(0.2);Exp 3,1(0.05);Exp 4,3(0.15);Hill,1(0.05);Linear,2(0.1);Poly 2,7(0.35);Power,2(0.1) 1.8728551305714627 38.765389800071716 1.522104263305664 4.21828556060791 0.6213800205519449 1.7495600581169128 33.19947622855423 66.42297657144577 22.01026045693764 47.155100343062344 52.69492838682058 103.75010861317944 DOWN 0.35 0.65 0.0 GO:0042537 5 benzene-containing compound metabolic process 17 24 3 3 3 3 3 3 159 21 2364 0.93819 0.19305 0.19305 12.5 286954;81869;25146 ugt2b1;gstm7;cyp17a1 UGT2B10_33303,UGT2B1_33224;GSTM7_8761;CYP17A1_32365 46.49361666666666 47.47345 42.3152 3.7848497025422354 46.24214694320417 3.3927177242411486 33.96601666666667 34.82915 31.4035 2.2582509306613607 33.90091945702064 2.098656245311344 74.23825 76.47475 64.5991 8.738259895282562 73.65002476816437 7.826303908588586 0.5 44.894324999999995 1.5 48.582825 47.47345;42.3152;49.6922 34.82915;31.4035;35.6654 76.47475;64.5991;81.6409 4 0 3 286954;81869;25146 UGT2B10_33303,UGT2B1_33224;GSTM7_8761;CYP17A1_32365 46.49361666666666 47.47345 3.7848497025422354 33.96601666666667 34.82915 2.2582509306613607 74.23825 76.47475 8.738259895282562 47.47345;42.3152;49.6922 34.82915;31.4035;35.6654 76.47475;64.5991;81.6409 0 0 Exp 2,2(0.5);Linear,2(0.5) 1.7660959364489681 7.074563026428223 1.6419988870620728 1.90940523147583 0.1098691124087001 1.76157945394516 42.210656037240895 50.77657729609243 31.410565172545045 36.52146816078829 64.34997806253125 84.12652193746874 UP 1.0 0.0 0.0 GO:0006489 6 dolichyl diphosphate biosynthetic process 1 1 1 1 1 1 1 1 161 0 2385 1.0 0.063604 0.063604 100.0 298541 dhdds DHDDS_8467 47.9438 47.9438 47.9438 47.9438 36.5688 36.5688 36.5688 36.5688 71.3742 71.3742 71.3742 71.3742 0.0 47.9438 0.0 47.9438 47.9438 36.5688 71.3742 1 0 1 298541 DHDDS_8467 47.9438 47.9438 36.5688 36.5688 71.3742 71.3742 47.9438 36.5688 71.3742 0 0 Exp 2,1(1) 1.7512425184249878 1.7512425184249878 1.7512425184249878 1.7512425184249878 0.0 1.7512425184249878 47.9438 47.9438 36.5688 36.5688 71.3742 71.3742 UP 1.0 0.0 0.0 GO:0046465 6 dolichyl diphosphate metabolic process 1 1 1 1 1 1 1 1 161 0 2385 1.0 0.063604 0.063604 100.0 298541 dhdds DHDDS_8467 47.9438 47.9438 47.9438 47.9438 36.5688 36.5688 36.5688 36.5688 71.3742 71.3742 71.3742 71.3742 0.0 47.9438 0.0 47.9438 47.9438 36.5688 71.3742 1 0 1 298541 DHDDS_8467 47.9438 47.9438 36.5688 36.5688 71.3742 71.3742 47.9438 36.5688 71.3742 0 0 Exp 2,1(1) 1.7512425184249878 1.7512425184249878 1.7512425184249878 1.7512425184249878 0.0 1.7512425184249878 47.9438 47.9438 36.5688 36.5688 71.3742 71.3742 UP 1.0 0.0 0.0 GO:0031669 5 cellular response to nutrient levels 87 92 13 13 11 8 6 6 156 86 2299 0.63165 0.53728 0.8294 6.52 24539;24516;24957;294515;114851;246142 lpl;jun;glul;foxo3;cdkn1a;bmf LPL_32544;JUN_8938;GLUL_32832;FOXO3_8662;CDKN1A_8271;BMF_8152 38.571495 21.44965 6.24967 36.78334710601728 49.054950200491106 40.40874087821182 27.115175000000004 15.783999999999999 2.44025 28.340473653553325 35.13593880298983 31.111928163520187 65.4085 37.67965 19.0606 54.47919471240375 79.7051964866834 59.84408953795836 3.5 50.335499999999996 74.2041;16.4324;26.4669;13.1992;6.24967;94.8767 49.8682;10.5224;21.0456;5.6804;2.44025;73.1342 155.425;39.929;35.4303;32.7581;19.0606;109.848 2 4 2 24539;246142 LPL_32544;BMF_8152 84.5404 84.5404 14.617735644756898 61.501200000000004 61.501200000000004 16.45154637108624 132.6365 132.6365 32.227805766139305 74.2041;94.8767 49.8682;73.1342 155.425;109.848 4 24516;24957;294515;114851 JUN_8938;GLUL_32832;FOXO3_8662;CDKN1A_8271 15.587042499999999 14.8158 8.405836177554955 9.922162499999999 8.1014 8.125324827083839 31.7945 34.0942 8.990177344561493 16.4324;26.4669;13.1992;6.24967 10.5224;21.0456;5.6804;2.44025 39.929;35.4303;32.7581;19.0606 0 Exp 2,1(0.17);Exp 4,2(0.34);Linear,1(0.17);Poly 2,2(0.34) 1.8297204586716025 11.111794352531433 1.522104263305664 2.3622660636901855 0.3200493605994269 1.8398417830467224 9.138687395801938 68.00430260419806 4.438073156801384 49.79227684319862 21.816065309913967 109.00093469008604 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0030162 7 regulation of proteolysis 214 230 25 25 23 23 21 21 141 209 2176 0.96929 0.053207 0.087259 9.13 246273;79224;24794;24648;25106;252922;29441;25513;299282;288001;54404;50693;306251;63868;25661;83928;24360;25423;113936;25377;25373 trib3;serpind1;serpina3c;serpina1;rgn;pzp;por;pik3r1;loc299282;kng1;itih4;itih3;itih1;hspd1;fn1;fetub;fabp1;ctsc;cpb2;ambp;ahsg TRIB3_10079;SERPIND1_9812;SERPINA3C_32925;SERPINA1_9807;RGN_9699;PZP_9633;POR_9531;PIK3R1_32562;LOC299282_9119;KNG1L1_34113;ITIH4_32725;ITIH3_32422;ITIH1_33132;HSPD1_8849;FN1_8655;FETUB_33027;FABP1_33091;CTSC_32456;CPB2_8369;AMBP_33085;AHSG_8003 40.78939523809523 32.5155 12.402 26.86671324377949 47.36260083744565 26.578116497804142 27.921210000000002 23.347 8.48981 17.66996700615199 30.495085765476137 16.63512831912087 63.5560619047619 48.5666 15.4235 36.25150334441977 76.13835870620998 33.293756708066866 10.5 33.181650000000005 108.064;28.261;29.766;15.797;77.4407;34.1871;12.4414;18.7324;45.2017;24.3655;57.1163;27.1247;98.1741;42.2579;59.5777;32.5155;33.8478;56.2386;25.8316;17.2343;12.402 83.8836;22.307;23.347;13.013;58.7732;26.3085;8.48981;11.6701;30.7472;19.538;39.6402;21.5108;42.9071;23.9469;31.0499;19.6094;26.4736;38.2681;20.4374;14.1233;10.3013 143.428;38.3264;40.8256;19.9134;89.8047;48.5666;79.2355;41.5978;78.6415;32.1467;101.869;36.4819;104.278;102.383;105.243;49.9875;46.9257;102.888;34.8042;21.9073;15.4235 3 18 3 25106;63868;24360 RGN_9699;HSPD1_8849;FABP1_33091 51.18213333333333 42.2579 23.126104039447146 36.3979 26.4736 19.418717537211357 79.70446666666668 89.8047 29.075575073647812 77.4407;42.2579;33.8478 58.7732;23.9469;26.4736 89.8047;102.383;46.9257 18 246273;79224;24794;24648;252922;29441;25513;299282;288001;54404;50693;306251;25661;83928;25423;113936;25377;25373 TRIB3_10079;SERPIND1_9812;SERPINA3C_32925;SERPINA1_9807;PZP_9633;POR_9531;PIK3R1_32562;LOC299282_9119;KNG1L1_34113;ITIH4_32725;ITIH3_32422;ITIH1_33132;FN1_8655;FETUB_33027;CTSC_32456;CPB2_8369;AMBP_33085;AHSG_8003 39.057272222222224 29.0135 27.64133809274468 26.50842833333333 21.9089 17.55477401406582 60.86466111111112 45.0822 37.32209040362871 108.064;28.261;29.766;15.797;34.1871;12.4414;18.7324;45.2017;24.3655;57.1163;27.1247;98.1741;59.5777;32.5155;56.2386;25.8316;17.2343;12.402 83.8836;22.307;23.347;13.013;26.3085;8.48981;11.6701;30.7472;19.538;39.6402;21.5108;42.9071;31.0499;19.6094;38.2681;20.4374;14.1233;10.3013 143.428;38.3264;40.8256;19.9134;48.5666;79.2355;41.5978;78.6415;32.1467;101.869;36.4819;104.278;105.243;49.9875;102.888;34.8042;21.9073;15.4235 0 Exp 2,7(0.34);Exp 3,2(0.1);Linear,6(0.29);Poly 2,5(0.24);Power,1(0.05) 1.8632180059348458 40.10315203666687 1.5197933912277222 3.431420087814331 0.4849834785055193 1.7033517360687256 29.29831217409464 52.28047830209582 20.363640275580725 35.47877972441929 48.05103781246538 79.0610859970584 DOWN 0.14285714285714285 0.8571428571428571 0.0 GO:1903426 6 regulation of reactive oxygen species biosynthetic process 44 48 6 6 6 6 6 6 156 42 2343 0.97016 0.08069 0.12207 12.5 25106;63868;294515;24890;29184;25698 rgn;hspd1;foxo3;esr1;cd36;ass1 RGN_9699;HSPD1_8849;FOXO3_8662;ESR1_33192;CD36_8243;ASS1_33159 38.53805 34.5308 13.1992 22.927053541242497 44.459579689790345 20.272957016433242 27.53918333333333 22.4647 5.6804 18.409492815329454 32.24976841656724 16.460304819956967 60.45193333333333 52.9251 31.9156 31.113850953083062 69.14838922788479 28.33146146686651 1.5 25.100450000000002 3.5 45.19375 77.4407;42.2579;13.1992;23.3972;48.1296;26.8037 58.7732;23.9469;5.6804;18.3088;37.5433;20.9825 89.8047;102.383;32.7581;31.9156;69.1421;36.7081 3 3 3 25106;63868;29184 RGN_9699;HSPD1_8849;CD36_8243 55.94273333333334 48.1296 18.847841874425114 40.0878 37.5433 17.55202703706897 87.10993333333333 89.8047 16.783494384166104 77.4407;42.2579;48.1296 58.7732;23.9469;37.5433 89.8047;102.383;69.1421 3 294515;24890;25698 FOXO3_8662;ESR1_33192;ASS1_33159 21.133366666666667 23.3972 7.079146211467403 14.990566666666666 18.3088 8.172916887093212 33.793933333333335 32.7581 2.5586572813359565 13.1992;23.3972;26.8037 5.6804;18.3088;20.9825 32.7581;31.9156;36.7081 0 Exp 2,3(0.5);Exp 3,1(0.17);Exp 4,1(0.17);Poly 2,1(0.17) 2.133399556309511 12.948805212974548 1.7198865413665771 2.6703107357025146 0.35953357808273506 2.12009596824646 20.192586389372018 56.88351361062798 12.808521151809897 42.26984551485677 35.555667469099895 85.34819919756677 CONFLICT 0.5 0.5 0.0 GO:0060134 7 prepulse inhibition 4 4 1 1 1 1 1 1 161 3 2382 0.97784 0.23128 0.23128 25.0 80841 fabp7 FABP7_8592 24.601 24.601 24.601 24.601000000000003 14.4402 14.4402 14.4402 14.440200000000003 35.6155 35.6155 35.6155 35.6155 0.0 24.601 0.0 24.601 24.601 14.4402 35.6155 1 0 1 80841 FABP7_8592 24.601 24.601 14.4402 14.4402 35.6155 35.6155 24.601 14.4402 35.6155 0 0 Hill,1(1) 1.9328917264938354 1.9328917264938354 1.9328917264938354 1.9328917264938354 0.0 1.9328917264938354 24.601 24.601 14.4402 14.4402 35.6155 35.6155 UP 1.0 0.0 0.0 GO:0016101 7 diterpenoid metabolic process 22 26 6 6 5 4 3 3 159 23 2362 0.92111 0.2269 0.2269 11.54 24856;65210;65183 ttr;cyp2j4;aldh3a2 TTR_10102;CYP2J4_32580;ALDH3A2_8024 35.86266666666666 43.1079 17.8395 15.708147403285132 35.29795736193341 15.987482394344092 25.038366666666665 28.5876 14.6501 9.145641544655756 24.645804751043386 9.241769921921664 50.878433333333334 63.7146 22.6149 24.511202882015674 49.890470246530136 24.862533036394424 0.5 30.4737 1.5 44.87425 46.6406;17.8395;43.1079 28.5876;14.6501;31.8774 63.7146;22.6149;66.3058 3 0 3 24856;65210;65183 TTR_10102;CYP2J4_32580;ALDH3A2_8024 35.86266666666666 43.1079 15.708147403285132 25.038366666666665 28.5876 9.145641544655756 50.878433333333334 63.7146 24.511202882015674 46.6406;17.8395;43.1079 28.5876;14.6501;31.8774 63.7146;22.6149;66.3058 0 0 Linear,2(0.67);Poly 2,1(0.34) 2.233670621634106 7.253257989883423 1.520427942276001 3.8079800605773926 1.2208351484487105 1.9248499870300293 18.08722452842296 53.63810880491036 14.689098995537767 35.38763433779556 23.141396152430506 78.61547051423616 UP 1.0 0.0 0.0 GO:1901362 5 organic cyclic compound biosynthetic process 212 234 41 41 29 31 22 22 140 212 2173 0.97958 0.036468 0.049533 9.4 293688;65192;298490;303612;24651;81819;294103;100359982;24516;29540;289456;25675;24443;294515;314322;24890;24330;25428;25146;497840;25028;25284 tm7sf2;slc27a2;ppcs;polg2;pklr;pax8;papss2;mpc2;jun;hsd17b7;hsd17b11;hmgcr;hdc;foxo3;fos;esr1;egr1;cyp7a1;cyp17a1;cps1;ampd1;amacr TM7SF2_10031;SLC27A2_9860;PPCS_9540;POLG2_9521;PKLR_9489;PAX8_9432;PAPSS2_33237;MPC2_33219;JUN_8938;HSD17B7_8834;HSD17B11_8832;HMGCR_8810;HDC_8788;FOXO3_8662;FOS_8657;ESR1_33192;EGR1_8533;CYP7A1_8430;CYP17A1_32365;CPS1_32421;AMPD1_32743;AMACR_8038 26.77527777272733 22.76485 1.28141E-12 23.938834223896325 30.05942050267591 24.43545709211164 19.35303050000006 17.7929 1.28141E-12 17.300005634358936 22.291933966685285 17.937684382697817 46.96081863636369 32.33685 1.28142E-12 49.1142382964651 50.458617092541 48.972027383887756 10.5 22.76485 82.3097;7.62189;20.3353;63.7758;23.0963;56.8931;34.4443;46.8463;16.4324;0.977494;22.4334;1.63089;24.5745;13.1992;1.28141E-12;23.3972;0.750017;5.72128;49.6922;31.9826;60.9045;2.03774 51.1696;5.49916;16.7643;40.9553;17.4625;45.1162;25.719;35.8494;10.5224;0.322682;18.1233;0.663137;21.0619;5.6804;1.28141E-12;18.3088;0.186019;0.985273;35.6654;24.4836;50.0633;1.165 209.842;13.3925;25.6711;132.567;32.9443;81.5688;51.1014;69.127;39.929;5.49472;29.2247;7.6286;29.28;32.7581;1.28142E-12;31.9156;4.70178;22.3625;81.6409;45.5891;82.6625;3.73641 9 13 9 65192;298490;81819;100359982;289456;24443;25146;25028;25284 SLC27A2_9860;PPCS_9540;PAX8_9432;MPC2_33219;HSD17B11_8832;HDC_8788;CYP17A1_32365;AMPD1_32743;AMACR_8038 32.37099222222222 24.5745 21.685469728337555 25.478662222222223 21.0619 17.10717343630573 46.25599 29.28 32.08877121521094 7.62189;20.3353;56.8931;46.8463;22.4334;24.5745;49.6922;60.9045;2.03774 5.49916;16.7643;45.1162;35.8494;18.1233;21.0619;35.6654;50.0633;1.165 13.3925;25.6711;81.5688;69.127;29.2247;29.28;81.6409;82.6625;3.73641 13 293688;303612;24651;294103;24516;29540;25675;294515;314322;24890;24330;25428;497840 TM7SF2_10031;POLG2_9521;PKLR_9489;PAPSS2_33237;JUN_8938;HSD17B7_8834;HMGCR_8810;FOXO3_8662;FOS_8657;ESR1_33192;EGR1_8533;CYP7A1_8430;CPS1_32421 22.901321615384713 16.4324 25.487644934121334 15.112208538461637 10.5224 16.76390301684296 47.44877692307702 32.7581 59.449766031246746 82.3097;63.7758;23.0963;34.4443;16.4324;0.977494;1.63089;13.1992;1.28141E-12;23.3972;0.750017;5.72128;31.9826 51.1696;40.9553;17.4625;25.719;10.5224;0.322682;0.663137;5.6804;1.28141E-12;18.3088;0.186019;0.985273;24.4836 209.842;132.567;32.9443;51.1014;39.929;5.49472;7.6286;32.7581;1.28142E-12;31.9156;4.70178;22.3625;45.5891 0 Exp 2,10(0.46);Exp 4,4(0.19);Hill,4(0.19);Linear,3(0.14);Poly 2,1(0.05) 2.2775810711263684 62.97080993652344 1.5504547357559204 17.513065338134766 3.363229814214725 1.9055876731872559 16.771875626431648 36.778679919023006 12.123818255365272 26.58224274463484 26.437284691753323 67.48435258097406 CONFLICT 0.4090909090909091 0.5909090909090909 0.0 GO:0007507 5 heart development 69 74 4 4 3 4 3 3 159 71 2314 0.29593 0.86102 0.62592 4.05 25661;114851;24158 fn1;cdkn1a;acadm FN1_8655;CDKN1A_8271;ACADM_7957 25.84702333333333 11.7137 6.24967 29.33910048473936 30.536096069410096 31.520186389623102 13.950553333333334 8.36151 2.44025 15.10152549635411 15.96076668624161 16.520014091404647 47.75593333333333 19.0606 18.9642 49.7852834549863 56.84279157541504 52.393212123837 59.5777;6.24967;11.7137 31.0499;2.44025;8.36151 105.243;19.0606;18.9642 1 2 1 24158 ACADM_7957 11.7137 11.7137 8.36151 8.36151 18.9642 18.9642 11.7137 8.36151 18.9642 2 25661;114851 FN1_8655;CDKN1A_8271 32.913685 32.913685 37.70861164031964 16.745075 16.745075 20.230077522373712 62.151799999999994 62.151799999999994 60.94015945893151 59.5777;6.24967 31.0499;2.44025 105.243;19.0606 0 Exp 4,1(0.34);Poly 2,1(0.34);Power,1(0.34) 1.6613074048948913 4.9943989515304565 1.522104263305664 1.7792335748672485 0.1308736162400179 1.693061113357544 -7.353294289452336 59.047340956119 -3.138431495234995 31.03953816190166 -8.581418403326275 104.09328506999293 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0097193 6 intrinsic apoptotic signaling pathway 66 67 7 7 7 4 4 4 158 63 2322 0.57574 0.62644 1.0 5.97 246273;25513;140942;114851 trib3;pik3r1;ddit4;cdkn1a TRIB3_10079;PIK3R1_32562;DDIT4_8450;CDKN1A_8271 55.1470425 53.13725 6.24967 50.221586883502845 39.531846163750416 50.407292592109464 37.8098125 32.4577 2.44025 37.83886313470969 27.43034270386266 38.77413944416357 112.3946 92.5129 19.0606 103.92531332413677 74.40842753383954 88.26714925640975 2.5 97.80305 108.064;18.7324;87.5421;6.24967 83.8836;11.6701;53.2453;2.44025 143.428;41.5978;245.492;19.0606 0 4 0 4 246273;25513;140942;114851 TRIB3_10079;PIK3R1_32562;DDIT4_8450;CDKN1A_8271 55.1470425 53.13725 50.221586883502845 37.8098125 32.4577 37.83886313470969 112.3946 92.5129 103.92531332413677 108.064;18.7324;87.5421;6.24967 83.8836;11.6701;53.2453;2.44025 143.428;41.5978;245.492;19.0606 0 Exp 4,1(0.25);Linear,1(0.25);Poly 2,2(0.5) 1.6803303578769189 6.7400370836257935 1.522104263305664 1.87713623046875 0.1459429323022692 1.6703982949256897 5.929887354167214 104.36419764583277 0.7277266279845165 74.8918983720155 10.547792942345964 214.24140705765404 DOWN 0.0 1.0 0.0 GO:0015912 8 short-chain fatty acid transport 1 1 1 1 1 1 1 1 161 0 2385 1.0 0.063604 0.063604 100.0 29184 cd36 CD36_8243 48.1296 48.1296 48.1296 48.1296 37.5433 37.5433 37.5433 37.5433 69.1421 69.1421 69.1421 69.1421 0.0 48.1296 0.0 48.1296 48.1296 37.5433 69.1421 1 0 1 29184 CD36_8243 48.1296 48.1296 37.5433 37.5433 69.1421 69.1421 48.1296 37.5433 69.1421 0 0 Exp 2,1(1) 2.6703107357025146 2.6703107357025146 2.6703107357025146 2.6703107357025146 0.0 2.6703107357025146 48.1296 48.1296 37.5433 37.5433 69.1421 69.1421 UP 1.0 0.0 0.0 GO:0015931 6 nucleobase-containing compound transport 29 31 4 4 3 4 3 3 159 28 2357 0.86955 0.31516 0.44393 9.68 79426;361074;297784 zfp36;slc25a30;rrs1 ZFP36_10204;SLC25A30_9856;RRS1_9755 37.91704466666667 53.013 0.348134 32.744042492642606 47.36815574219827 23.951188650994215 26.90250066666667 37.4804 0.118102 23.366071416504777 33.58013241646823 17.07805782447431 65.45367333333333 90.2594 1.15962 56.162163920313226 81.29106109913522 41.010170307762934 0.5 26.680567 0.348134;53.013;60.39 0.118102;37.4804;43.109 1.15962;90.2594;104.942 2 1 2 361074;297784 SLC25A30_9856;RRS1_9755 56.701499999999996 56.701499999999996 5.2163267248132525 40.294700000000006 40.294700000000006 3.9800212285865086 97.60069999999999 97.60069999999999 10.38216602544962 53.013;60.39 37.4804;43.109 90.2594;104.942 1 79426 ZFP36_10204 0.348134 0.348134 0.118102 0.118102 1.15962 1.15962 0.348134 0.118102 1.15962 0 Exp 2,1(0.34);Hill,1(0.34);Linear,1(0.34) 2.5270792498273984 7.8689833879470825 1.9381765127182007 3.648852586746216 0.9048947219757348 2.281954288482666 0.8636724415985029 74.97041689173483 0.46130172710948614 53.34369960622385 1.9002020363104464 129.0071446303562 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0050673 4 epithelial cell proliferation 37 39 6 6 3 6 3 3 159 36 2349 0.76649 0.4561 0.73503 7.69 246186;80841;24890 fgl1;fabp7;esr1 FGL1_8640;FABP7_8592;ESR1_33192 21.157966666666667 23.3972 15.4757 4.957660684570225 17.814814955047147 4.692383978782711 14.320933333333334 14.4402 10.2138 4.048817685860078 11.851686967326948 3.4992359319264676 32.64723333333333 31.9156 30.4106 2.678471859723983 31.367274446312404 2.2471808889783356 0.5 19.43645 15.4757;24.601;23.3972 10.2138;14.4402;18.3088 30.4106;35.6155;31.9156 1 2 1 80841 FABP7_8592 24.601 24.601 14.4402 14.4402 35.6155 35.6155 24.601 14.4402 35.6155 2 246186;24890 FGL1_8640;ESR1_33192 19.43645 19.43645 5.601346367169232 14.261300000000002 14.261300000000002 5.7240293937050994 31.1631 31.1631 1.0641957056857894 15.4757;23.3972 10.2138;18.3088 30.4106;31.9156 0 Exp 2,1(0.34);Hill,1(0.34);Poly 2,1(0.34) 1.923708128816048 5.8811997175216675 1.511321783065796 2.436986207962036 0.4634449070038965 1.9328917264938354 15.547845474323275 26.76808785901006 9.739264810904512 18.902601855762157 29.616257092845498 35.67820957382117 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0035359 7 negative regulation of peroxisome proliferator activated receptor signaling pathway 2 2 1 1 1 1 1 1 161 1 2384 0.99598 0.12319 0.12319 50.0 65210 cyp2j4 CYP2J4_32580 17.8395 17.8395 17.8395 17.8395 14.6501 14.6501 14.6501 14.650100000000002 22.6149 22.6149 22.6149 22.614899999999995 0.0 17.8395 0.0 17.8395 17.8395 14.6501 22.6149 1 0 1 65210 CYP2J4_32580 17.8395 17.8395 14.6501 14.6501 22.6149 22.6149 17.8395 14.6501 22.6149 0 0 Linear,1(1) 3.8079800605773926 3.8079800605773926 3.8079800605773926 3.8079800605773926 0.0 3.8079800605773926 17.8395 17.8395 14.6501 14.6501 22.6149 22.6149 UP 1.0 0.0 0.0 GO:0043393 5 regulation of protein binding 73 77 4 4 3 3 2 2 160 75 2310 0.12133 0.96249 0.23393 2.6 246273;114851 trib3;cdkn1a TRIB3_10079;CDKN1A_8271 57.156834999999994 57.156834999999994 6.24967 71.99360316496494 37.66746832564576 66.50870672280125 43.161925000000004 43.161925000000004 2.44025 57.5891450675494 27.57198484778598 53.201665027628785 81.2443 81.2443 19.0606 87.94103189853985 57.43780968634685 81.24116646917301 108.064;6.24967 83.8836;2.44025 143.428;19.0606 0 2 0 2 246273;114851 TRIB3_10079;CDKN1A_8271 57.156834999999994 57.156834999999994 71.99360316496494 43.161925000000004 43.161925000000004 57.5891450675494 81.2443 81.2443 87.94103189853985 108.064;6.24967 83.8836;2.44025 143.428;19.0606 0 Exp 4,1(0.5);Poly 2,1(0.5) 1.6903245425663107 3.399240493774414 1.522104263305664 1.87713623046875 0.2510455115190177 1.699620246887207 -42.62120839999999 156.93487839999997 -36.65255799999998 122.97640799999999 -40.635752 203.124352 DOWN 0.0 1.0 0.0 GO:0046324 7 regulation of glucose import 21 24 4 4 4 3 3 3 159 21 2364 0.93819 0.19305 0.19305 12.5 29482;24890;29496 slc1a2;esr1;erbb3 SLC1A2_33059;ESR1_33192;ERBB3_8571 32.573033333333335 23.3972 13.3235 25.12709614188104 36.91745096715467 27.89937848122021 23.007306666666665 18.3088 9.10952 16.74882928547943 25.493961089281658 18.818300228277103 56.85496666666666 31.9156 24.6773 49.597024803140485 67.35653747250247 53.557766726892396 0.5 18.36035 1.5 42.1978 13.3235;23.3972;60.9984 9.10952;18.3088;41.6036 24.6773;31.9156;113.972 1 2 1 29496 ERBB3_8571 60.9984 60.9984 41.6036 41.6036 113.972 113.972 60.9984 41.6036 113.972 2 29482;24890 SLC1A2_33059;ESR1_33192 18.36035 18.36035 7.123181581638923 13.70916 13.70916 6.504873270033785 28.29645 28.29645 5.118251014262586 13.3235;23.3972 9.10952;18.3088 24.6773;31.9156 0 Exp 2,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 1.8491642564351598 5.6586058139801025 1.6013026237487793 2.436986207962036 0.47708790646082827 1.620316982269287 4.139047319254818 61.00701934741184 4.054222117364702 41.96039121596863 0.7306496493151613 112.97928368401816 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0035556 5 intracellular signal transduction 318 334 26 26 23 22 19 19 143 315 2070 0.34546 0.74054 0.71788 5.69 79426;246273;24825;362895;308821;25513;25493;24567;24516;81678;25685;24471;25112;294515;29496;116636;140942;114851;29184 zfp36;trib3;tf;stac3;rab30;pik3r1;nfkbia;mt1;jun;itpr2;igfbp1;hspb1;gadd45a;foxo3;erbb3;eif4ebp1;ddit4;cdkn1a;cd36 ZFP36_10204;TRIB3_10079;TF_10003;STAC3_9953;RAB30_9639;PIK3R1_32562;NFKBIA_9307;MT1A_9255;JUN_8938;ITPR2_8931;IGFBP1_32306;HSPB1_8847;GADD45A_8678;FOXO3_8662;ERBB3_8571;EIF4EBP1_8550;DDIT4_8450;CDKN1A_8271;CD36_8243 45.51148710526315 45.1539 0.348134 35.549707339712306 51.4888007052799 34.39533001822993 31.436520210526318 28.132 0.118102 26.651538363671783 36.54019098183137 27.02413636661538 74.40446894736843 61.5341 1.15962 59.89444061663642 76.05167540012589 48.11086585005369 15.5 88.3216 0.348134;108.064;45.1539;63.2393;26.4203;18.7324;0.520151;12.9315;16.4324;31.8111;49.0259;89.1011;102.919;13.1992;60.9984;83.9001;87.5421;6.24967;48.1296 0.118102;83.8836;28.132;42.7031;21.0125;11.6701;0.160202;8.91033;10.5224;24.7342;32.6883;60.3265;89.5012;5.6804;41.6036;42.4185;53.2453;2.44025;37.5433 1.15962;143.428;61.5341;121.52;35.3561;41.5978;2.88499;23.4636;39.929;44.3296;89.1623;106.138;115.437;32.7581;113.972;107.32;245.492;19.0606;69.1421 5 14 5 24825;308821;29496;116636;29184 TF_10003;RAB30_9639;ERBB3_8571;EIF4EBP1_8550;CD36_8243 52.920460000000006 48.1296 21.27511153303314 34.141980000000004 37.5433 9.276969315838016 77.46486 69.1421 32.86451647420054 45.1539;26.4203;60.9984;83.9001;48.1296 28.132;21.0125;41.6036;42.4185;37.5433 61.5341;35.3561;113.972;107.32;69.1421 14 79426;246273;362895;25513;25493;24567;24516;81678;25685;24471;25112;294515;140942;114851 ZFP36_10204;TRIB3_10079;STAC3_9953;PIK3R1_32562;NFKBIA_9307;MT1A_9255;JUN_8938;ITPR2_8931;IGFBP1_32306;HSPB1_8847;GADD45A_8678;FOXO3_8662;DDIT4_8450;CDKN1A_8271 42.865425357142854 25.271749999999997 39.773456143040406 30.47028457142857 18.20215 30.873892615769517 73.31147214285714 42.9637 68.0431602703662 0.348134;108.064;63.2393;18.7324;0.520151;12.9315;16.4324;31.8111;49.0259;89.1011;102.919;13.1992;87.5421;6.24967 0.118102;83.8836;42.7031;11.6701;0.160202;8.91033;10.5224;24.7342;32.6883;60.3265;89.5012;5.6804;53.2453;2.44025 1.15962;143.428;121.52;41.5978;2.88499;23.4636;39.929;44.3296;89.1623;106.138;115.437;32.7581;245.492;19.0606 0 Exp 2,2(0.11);Exp 3,1(0.06);Exp 4,3(0.16);Hill,1(0.06);Linear,5(0.27);Poly 2,7(0.37) 1.9994857419641783 39.331257820129395 1.522104263305664 3.9562058448791504 0.6253699445451294 1.8546061515808105 29.526389196744518 61.49658501378178 19.452527034863177 43.420513386189455 47.472643931656876 101.33629396307998 DOWN 0.2631578947368421 0.7368421052631579 0.0 GO:0046687 5 response to chromate 3 3 2 2 2 2 2 2 160 1 2384 0.99975 0.011561 0.011561 66.67 24648;24567 serpina1;mt1 SERPINA1_9807;MT1A_9255 14.36425 14.36425 12.9315 2.02621448149005 14.0888313339046 1.9884250656568367 10.961665 10.961665 8.91033 2.9010257779706152 10.567335249928592 2.846920908783257 21.688499999999998 21.688499999999998 19.9134 2.5103704945685084 22.029728877463583 2.4635514458540855 0.0 12.9315 0.0 12.9315 15.797;12.9315 13.013;8.91033 19.9134;23.4636 0 2 0 2 24648;24567 SERPINA1_9807;MT1A_9255 14.36425 14.36425 2.02621448149005 10.961665 10.961665 2.9010257779706152 21.688499999999998 21.688499999999998 2.5103704945685084 15.797;12.9315 13.013;8.91033 19.9134;23.4636 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.967834428391043 3.9767355918884277 1.7033517360687256 2.273383855819702 0.4030735773700576 1.9883677959442139 11.556059999999999 17.17244 6.941048400000001 14.9822816 18.209303999999996 25.167696 DOWN 0.0 1.0 0.0 GO:0060612 6 adipose tissue development 13 14 3 3 2 3 2 2 160 12 2373 0.94527 0.22236 0.22236 14.29 83516;246186 ppargc1a;fgl1 PPARGC1A_33189;FGL1_8640 28.942549999999997 28.942549999999997 15.4757 19.04500191244412 25.087416058960432 18.247958308761262 18.2563 18.2563 10.2138 11.373812575385625 15.953986190845615 10.897812383609576 56.070550000000004 56.070550000000004 30.4106 36.28864929981551 48.724916524437546 34.769949751047875 0.0 15.4757 0.5 28.942549999999997 42.4094;15.4757 26.2988;10.2138 81.7305;30.4106 0 2 0 2 83516;246186 PPARGC1A_33189;FGL1_8640 28.942549999999997 28.942549999999997 19.04500191244412 18.2563 18.2563 11.373812575385625 56.070550000000004 56.070550000000004 36.28864929981551 42.4094;15.4757 26.2988;10.2138 81.7305;30.4106 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.6298263839566574 3.2689448595046997 1.511321783065796 1.7576230764389038 0.17416131475914187 1.6344724297523499 2.5475239999999992 55.337576 2.4929999999999986 34.0196 5.777048000000001 106.36405200000002 DOWN 0.0 1.0 0.0 GO:0001817 5 regulation of cytokine production 196 207 16 16 12 15 11 11 151 196 2189 0.32035 0.78191 0.65517 5.31 79426;29573;25513;25591;24539;63868;24471;25661;24330;65210;29184 zfp36;slc37a4;pik3r1;parp1;lpl;hspd1;hspb1;fn1;egr1;cyp2j4;cd36 ZFP36_10204;SLC37A4_9871;PIK3R1_32562;PARP1_9425;LPL_32544;HSPD1_8849;HSPB1_8847;FN1_8655;EGR1_8533;CYP2J4_32580;CD36_8243 37.966468272727276 39.7166 0.348134 28.663234567819043 43.31216166544689 27.115638130031325 24.895383727272726 22.6911 0.118102 18.96454548142679 28.372045595043954 17.84760621543607 63.97439090909091 60.0334 1.15962 48.84176722185827 72.54470510427855 48.17441634728992 9.5 81.6526 0.348134;39.7166;18.7324;26.9741;74.2041;42.2579;89.1011;59.5777;0.750017;17.8395;48.1296 0.118102;22.6911;11.6701;21.799;49.8682;23.9469;60.3265;31.0499;0.186019;14.6501;37.5433 1.15962;60.0334;41.5978;35.2797;155.425;102.383;106.138;105.243;4.70178;22.6149;69.1421 5 6 5 25591;24539;63868;65210;29184 PARP1_9425;LPL_32544;HSPD1_8849;CYP2J4_32580;CD36_8243 41.88104 42.2579 21.703566751988028 29.561500000000002 23.9469 14.055258673357812 76.96894 69.1421 53.74672459064833 26.9741;74.2041;42.2579;17.8395;48.1296 21.799;49.8682;23.9469;14.6501;37.5433 35.2797;155.425;102.383;22.6149;69.1421 6 79426;29573;25513;24471;25661;24330 ZFP36_10204;SLC37A4_9871;PIK3R1_32562;HSPB1_8847;FN1_8655;EGR1_8533 34.70432516666667 29.2245 35.1885268090605 21.006953499999998 17.1806 22.833116846036557 53.1456 50.8156 46.37342521520876 0.348134;39.7166;18.7324;89.1011;59.5777;0.750017 0.118102;22.6911;11.6701;60.3265;31.0499;0.186019 1.15962;60.0334;41.5978;106.138;105.243;4.70178 0 Exp 2,3(0.28);Exp 3,1(0.1);Hill,2(0.19);Linear,1(0.1);Poly 2,3(0.28);Power,1(0.1) 2.171141428791257 25.298388481140137 1.559399127960205 4.21828556060791 0.9058742609230073 1.893584966659546 21.027579099525003 54.90535744592955 13.688053536746887 36.10271391779857 35.110750972122325 92.83803084605952 CONFLICT 0.45454545454545453 0.5454545454545454 0.0 GO:0042447 5 hormone catabolic process 7 11 4 4 3 2 2 2 160 9 2376 0.97146 0.15174 0.15174 18.18 360268;289456 sult1e1;hsd17b11 SULT1E1_32446;HSD17B11_8832 36.309 36.309 22.4334 19.623061706064135 32.60637774080852 18.91152367027786 27.3121 27.3121 18.1233 12.994925581933902 24.860122758276496 12.523725727280203 55.10175 55.10175 29.2247 36.5956750642067 48.196611387456336 35.268705035599424 0.0 22.4334 0.5 36.309 50.1846;22.4334 36.5009;18.1233 80.9788;29.2247 2 0 2 360268;289456 SULT1E1_32446;HSD17B11_8832 36.309 36.309 19.623061706064135 27.3121 27.3121 12.994925581933902 55.10175 55.10175 36.5956750642067 50.1846;22.4334 36.5009;18.1233 80.9788;29.2247 0 0 Exp 2,1(0.5);Linear,1(0.5) 1.8160441931460323 3.63539719581604 1.7401635646820068 1.8952336311340332 0.1096510955472764 1.81769859790802 9.112823999999993 63.505176000000006 9.302052 45.322148 4.382731999999997 105.82076800000002 UP 1.0 0.0 0.0 GO:0001936 7 regulation of endothelial cell proliferation 43 44 4 4 3 3 2 2 160 42 2343 0.46194 0.78128 1.0 4.55 24794;24516 serpina3c;jun SERPINA3C_32925;JUN_8938 23.0992 23.0992 16.4324 9.428278977628961 22.41330672451193 9.37824852034113 16.9347 16.9347 10.5224 9.068361626005004 16.274990176634645 9.020241043226648 40.377300000000005 40.377300000000005 39.929 0.6339919400111456 40.33117802912923 0.6306277091953186 29.766;16.4324 23.347;10.5224 40.8256;39.929 0 2 0 2 24794;24516 SERPINA3C_32925;JUN_8938 23.0992 23.0992 9.428278977628961 16.9347 16.9347 9.068361626005004 40.377300000000005 40.377300000000005 0.6339919400111456 29.766;16.4324 23.347;10.5224 40.8256;39.929 0 Linear,1(0.5);Poly 2,1(0.5) 1.7904160522731758 3.5987131595611572 1.6202073097229004 1.9785058498382568 0.25335532740480876 1.7993565797805786 10.032272000000003 36.166128 4.366592000000001 29.502807999999998 39.49863200000001 41.255968 DOWN 0.0 1.0 0.0 GO:0046689 6 response to mercury ion 10 11 2 2 2 2 2 2 160 9 2376 0.97146 0.15174 0.15174 18.18 25661;65054 fn1;aqp9 FN1_8655;AQP9_32709 43.654650000000004 43.654650000000004 27.7316 22.518593264344894 54.88415890987124 15.9650650450052 26.49355 26.49355 21.9372 6.443651964918664 29.7068522832618 4.568372523970561 71.35275 71.35275 37.4625 47.92805118221477 95.25337609442059 33.97967384649838 0.0 27.7316 0.5 43.654650000000004 59.5777;27.7316 31.0499;21.9372 105.243;37.4625 0 2 0 2 25661;65054 FN1_8655;AQP9_32709 43.654650000000004 43.654650000000004 22.518593264344894 26.49355 26.49355 6.443651964918664 71.35275 71.35275 47.92805118221477 59.5777;27.7316 31.0499;21.9372 105.243;37.4625 0 Linear,1(0.5);Power,1(0.5) 1.7980771005460994 3.596353769302368 1.7792335748672485 1.8171201944351196 0.026789885612676596 1.798176884651184 12.445472000000002 74.86382800000001 17.563104 35.423996 4.927860000000024 137.77763999999996 DOWN 0.0 1.0 0.0 GO:0006699 7 bile acid biosynthetic process 6 6 4 4 4 3 3 3 159 3 2382 0.99979 0.0043808 0.0043808 50.0 65192;25428;25284 slc27a2;cyp7a1;amacr SLC27A2_9860;CYP7A1_8430;AMACR_8038 5.12697 5.72128 2.03774 2.8391171317330315 6.37354118948619 2.700005739286 2.549811 1.165 0.985273 2.5557914804386916 4.290409500965251 2.400584886881612 13.163803333333334 13.3925 3.73641 9.315150766146157 12.201241282298781 5.908140844578448 0.0 2.03774 0.0 2.03774 7.62189;5.72128;2.03774 5.49916;0.985273;1.165 13.3925;22.3625;3.73641 2 1 2 65192;25284 SLC27A2_9860;AMACR_8038 4.829815 4.829815 3.9485903321628593 3.33208 3.33208 3.0647139267474865 8.564455 8.564455 6.82788671874761 7.62189;2.03774 5.49916;1.165 13.3925;3.73641 1 25428 CYP7A1_8430 5.72128 5.72128 0.985273 0.985273 22.3625 22.3625 5.72128 0.985273 22.3625 0 Exp 4,1(0.34);Hill,2(0.67) 2.4967499676217053 8.307234048843384 1.5621941089630127 4.560328960418701 1.5821873378867533 2.18471097946167 1.9142065210767885 8.339733478923211 -0.34233932247870813 5.441961322478708 2.6227179206755267 23.70488874599114 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0010165 6 response to X-ray 13 13 4 4 3 4 3 3 159 10 2375 0.99283 0.045051 0.045051 23.08 24464;361969;114851 hp;fga;cdkn1a HP_8823;FGA_8632;CDKN1A_8271 33.25282333333333 28.5803 6.24967 29.617150914084107 31.76770637532728 28.968796808443486 22.193183333333334 22.529 2.44025 19.587184174246012 21.30511144309256 19.273344162671343 64.7889 38.8511 19.0606 62.84853530091215 61.3217404859079 61.149487290801666 0.0 6.24967 0.5 17.414985 64.9285;28.5803;6.24967 41.6103;22.529;2.44025 136.455;38.8511;19.0606 0 3 0 3 24464;361969;114851 HP_8823;FGA_8632;CDKN1A_8271 33.25282333333333 28.5803 29.617150914084107 22.193183333333334 22.529 19.587184174246012 64.7889 38.8511 62.84853530091215 64.9285;28.5803;6.24967 41.6103;22.529;2.44025 136.455;38.8511;19.0606 0 Exp 2,1(0.34);Exp 4,1(0.34);Linear,1(0.34) 1.5651300468276128 4.697623133659363 1.522104263305664 1.6336230039596558 0.059500707048797674 1.541895866394043 -0.2621379703040816 66.76778463697076 0.02819786422461945 44.35816880244205 -6.330912797344453 135.90871279734444 DOWN 0.0 1.0 0.0 GO:0030522 5 intracellular receptor signaling pathway 38 42 2 2 2 2 2 2 160 40 2345 0.49392 0.75869 1.0 4.76 25493;24890 nfkbia;esr1 NFKBIA_9307;ESR1_33192 11.9586755 11.9586755 0.520151 16.176516481436927 13.555809904920215 16.01805259260441 9.234501000000002 9.234501000000002 0.160202 12.832996714828615 10.501524131648939 12.707285683832527 17.400295 17.400295 2.88499 20.527741192982 19.427033065159577 20.326653047575654 0.520151;23.3972 0.160202;18.3088 2.88499;31.9156 0 2 0 2 25493;24890 NFKBIA_9307;ESR1_33192 11.9586755 11.9586755 16.176516481436927 9.234501000000002 9.234501000000002 12.832996714828615 17.400295 17.400295 20.527741192982 0.520151;23.3972 0.160202;18.3088 2.88499;31.9156 0 Exp 2,1(0.5);Exp 4,1(0.5) 2.125946756766026 4.291592359542847 1.8546061515808105 2.436986207962036 0.4118048870949685 2.1457961797714233 -10.46083252 34.37818352000001 -8.55112504 27.02012704 -11.049702799999999 45.8502928 DOWN 0.0 1.0 0.0 GO:0006542 9 glutamine biosynthetic process 1 1 1 1 1 1 1 1 161 0 2385 1.0 0.063604 0.063604 100.0 24957 glul GLUL_32832 26.4669 26.4669 26.4669 26.4669 21.0456 21.0456 21.0456 21.0456 35.4303 35.4303 35.4303 35.4303 0.0 26.4669 0.0 26.4669 26.4669 21.0456 35.4303 0 1 0 1 24957 GLUL_32832 26.4669 26.4669 21.0456 21.0456 35.4303 35.4303 26.4669 21.0456 35.4303 0 Linear,1(1) 2.3622660636901855 2.3622660636901855 2.3622660636901855 2.3622660636901855 0.0 2.3622660636901855 26.4669 26.4669 21.0456 21.0456 35.4303 35.4303 DOWN 0.0 1.0 0.0 GO:0008610 5 lipid biosynthetic process 109 122 29 29 20 21 14 14 148 108 2277 0.99091 0.020523 0.033236 11.48 293688;65192;246074;25513;24539;29540;289456;25675;298541;25428;25146;362866;25284;362732 tm7sf2;slc27a2;scd;pik3r1;lpl;hsd17b7;hsd17b11;hmgcr;dhdds;cyp7a1;cyp17a1;chpt1;amacr;agmo TM7SF2_10031;SLC27A2_9860;SCD1_9787;PIK3R1_32562;LPL_32544;HSD17B7_8834;HSD17B11_8832;HMGCR_8810;DHDDS_8467;CYP7A1_8430;CYP17A1_32365;CHPT1_33298;AMACR_8038;AGMO_33265 33.310999571428574 20.5829 0.977494 33.78784554029432 35.843323745679456 32.30453009275474 22.185953714285716 14.8967 0.322682 21.66287035509239 24.350076502731984 20.45249031768845 81.29780214285714 35.751400000000004 3.73641 115.11763783779165 82.19085880329679 108.04997686742831 5.5 17.39415 11.5 78.2569 82.3097;7.62189;105.46;18.7324;74.2041;0.977494;22.4334;1.63089;47.9438;5.72128;49.6922;16.0559;2.03774;31.5332 51.1696;5.49916;63.7532;11.6701;49.8682;0.322682;18.1233;0.663137;36.5688;0.985273;35.6654;10.6021;1.165;24.5474 209.842;13.3925;422.699;41.5978;155.425;5.49472;29.2247;7.6286;71.3742;22.3625;81.6409;29.905;3.73641;43.8459 9 5 9 65192;246074;24539;289456;298541;25146;362866;25284;362732 SLC27A2_9860;SCD1_9787;LPL_32544;HSD17B11_8832;DHDDS_8467;CYP17A1_32365;CHPT1_33298;AMACR_8038;AGMO_33265 39.664692222222214 31.5332 33.641548211302556 27.310284444444445 24.5474 20.98503158181273 94.58262333333333 43.8459 131.31175183163884 7.62189;105.46;74.2041;22.4334;47.9438;49.6922;16.0559;2.03774;31.5332 5.49916;63.7532;49.8682;18.1233;36.5688;35.6654;10.6021;1.165;24.5474 13.3925;422.699;155.425;29.2247;71.3742;81.6409;29.905;3.73641;43.8459 5 293688;25513;29540;25675;25428 TM7SF2_10031;PIK3R1_32562;HSD17B7_8834;HMGCR_8810;CYP7A1_8430 21.874352800000004 5.72128 34.531512105996015 12.962158400000002 0.985273 21.885760687459378 57.385124 22.3625 86.43964446139792 82.3097;18.7324;0.977494;1.63089;5.72128 51.1696;11.6701;0.322682;0.663137;0.985273 209.842;41.5978;5.49472;7.6286;22.3625 0 Exp 2,3(0.22);Exp 4,3(0.22);Hill,2(0.15);Linear,4(0.29);Poly 2,2(0.15) 1.960896598576374 28.681124687194824 1.559399127960205 4.560328960418701 0.7699717432450567 1.8232380747795105 15.611843712565879 51.010155430291256 10.838248270685641 33.53365915788579 20.99549574793349 141.6001085377808 UP 0.6428571428571429 0.35714285714285715 0.0 GO:0009437 6 carnitine metabolic process 7 8 6 6 4 6 4 4 158 4 2381 0.99995 9.0272E-4 9.0272E-4 50.0 29441;83842;24158;25287 por;crot;acadm;acadl POR_9531;CROT_8384;ACADM_7957;ACADL_32776 16.26645 12.077549999999999 7.4229 11.69247354055876 15.149776102941175 10.001974150978313 12.303072499999999 8.42566 5.75707 9.616664386193984 11.204539419786096 8.303979765324572 38.459625 32.1435 10.316 30.99414125910196 46.97721223930481 33.538785393589585 0.0 7.4229 0.0 7.4229 12.4414;7.4229;11.7137;33.4878 8.48981;5.75707;8.36151;26.6039 79.2355;10.316;18.9642;45.3228 3 1 3 83842;24158;25287 CROT_8384;ACADM_7957;ACADL_32776 17.54146666666667 11.7137 13.975582322155068 13.574160000000001 8.36151 11.358977519085947 24.86766666666667 18.9642 18.234779970521533 7.4229;11.7137;33.4878 5.75707;8.36151;26.6039 10.316;18.9642;45.3228 1 29441 POR_9531 12.4414 12.4414 8.48981 8.48981 79.2355 79.2355 12.4414 8.48981 79.2355 0 Exp 2,1(0.25);Poly 2,3(0.75) 2.4789775477320553 11.525779366493225 1.693061113357544 5.963563919067383 2.058260989536074 1.9345771670341492 4.807825930252417 27.72507406974758 2.878741401529899 21.727403598470104 8.08536656608008 68.83388343391992 UP 0.75 0.25 0.0 GO:0008630 7 intrinsic apoptotic signaling pathway in response to DNA damage 37 38 6 6 6 3 3 3 159 35 2350 0.7804 0.43898 0.7315 7.89 25513;140942;114851 pik3r1;ddit4;cdkn1a PIK3R1_32562;DDIT4_8450;CDKN1A_8271 37.50805666666667 18.7324 6.24967 43.7779482876326 20.104722894067795 33.2509779265145 22.45188333333333 11.6701 2.44025 27.064246068583426 11.427279512711864 20.773467650431385 102.05013333333333 41.5978 19.0606 124.73435044354595 54.84313347457626 93.00451715606712 0.5 12.491035 18.7324;87.5421;6.24967 11.6701;53.2453;2.44025 41.5978;245.492;19.0606 0 3 0 3 25513;140942;114851 PIK3R1_32562;DDIT4_8450;CDKN1A_8271 37.50805666666667 18.7324 43.7779482876326 22.45188333333333 11.6701 27.064246068583426 102.05013333333333 41.5978 124.73435044354595 18.7324;87.5421;6.24967 11.6701;53.2453;2.44025 41.5978;245.492;19.0606 0 Exp 4,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 1.619425477732489 4.8629008531570435 1.522104263305664 1.6735800504684448 0.08567669951455631 1.6672165393829346 -12.031355381064351 87.0474687143977 -8.174194182764051 53.077960849430724 -39.10007184598442 243.20033851265106 DOWN 0.0 1.0 0.0 GO:0001659 5 temperature homeostasis 11 12 3 3 2 3 2 2 160 10 2375 0.96369 0.17482 0.17482 16.67 24330;25287 egr1;acadl EGR1_8533;ACADL_32776 17.1189085 17.1189085 0.750017 23.149108360313672 10.383287669715559 21.098436954874668 13.3949595 13.3949595 0.186019 18.680262799679248 7.959624139765754 17.025465553360206 25.01229 25.01229 4.70178 28.723398700714377 16.654736024539876 26.178926945441088 0.0 0.750017 0.5 17.1189085 0.750017;33.4878 0.186019;26.6039 4.70178;45.3228 1 1 1 25287 ACADL_32776 33.4878 33.4878 26.6039 26.6039 45.3228 45.3228 33.4878 26.6039 45.3228 1 24330 EGR1_8533 0.750017 0.750017 0.186019 0.186019 4.70178 4.70178 0.750017 0.186019 4.70178 0 Exp 2,1(0.5);Hill,1(0.5) 2.8214994471150248 6.105511784553528 1.8872262239456177 4.21828556060791 1.6483078643021223 3.052755892276764 -14.964118840000001 49.201935840000004 -12.494563879999994 39.28448287999999 -14.796309599999994 64.82088959999999 CONFLICT 0.5 0.5 0.0 GO:0006749 5 glutathione metabolic process 22 29 4 4 4 4 4 4 158 25 2360 0.96652 0.1084 0.1084 13.79 293656;81869;57298;29328 rgd1307603;gstm7;gstm3l;gpx4 RGD1307603_9684;GSTM7_8761;GSTM3_8760;GPX4_32827 49.017225 44.1178 34.7372 16.715449933594357 51.024645392563436 15.967885941477483 35.80545 32.81165 26.1766 10.931296242898183 37.17372260490616 10.369012159598178 81.69745 67.51415 50.9085 40.27681536852188 85.76482673086386 39.37861366833747 0.5 38.5262 1.5 44.1178 34.7372;42.3152;73.0961;45.9204 26.1766;31.4035;51.4219;34.2198 50.9085;64.5991;140.853;70.4292 3 1 3 81869;57298;29328 GSTM7_8761;GSTM3_8760;GPX4_32827 53.777233333333335 45.9204 16.827457434898854 39.01506666666666 34.2198 10.836513343476017 91.96043333333334 70.4292 42.44242951273329 42.3152;73.0961;45.9204 31.4035;51.4219;34.2198 64.5991;140.853;70.4292 1 293656 RGD1307603_9684 34.7372 34.7372 26.1766 26.1766 50.9085 50.9085 34.7372 26.1766 50.9085 0 Exp 2,3(0.75);Linear,1(0.25) 1.8845343860343307 7.646208047866821 1.547789216041565 2.440005302429199 0.381945379795263 1.8292067646980286 32.63608406507752 65.39836593492248 25.09277968195978 46.51812031804022 42.226170938848554 121.16872906115145 UP 0.75 0.25 0.0 GO:0030278 5 regulation of ossification 54 58 3 3 2 2 2 2 160 56 2329 0.27462 0.89351 0.58234 3.45 25695;25373 cebpd;ahsg CEBPD_8283;AHSG_8003 6.354468 6.354468 0.306936 8.552501773285288 5.0764692653504015 8.359349559057573 5.1872671 5.1872671 0.0732342 7.232334685602209 4.106540685463224 7.068997512972386 8.580195 8.580195 1.73689 9.677894742455614 7.1340290052072035 9.459326322580267 0.306936;12.402 0.0732342;10.3013 1.73689;15.4235 0 2 0 2 25695;25373 CEBPD_8283;AHSG_8003 6.354468 6.354468 8.552501773285288 5.1872671 5.1872671 7.232334685602209 8.580195 8.580195 9.677894742455614 0.306936;12.402 0.0732342;10.3013 1.73689;15.4235 0 Exp 2,1(0.5);Hill,1(0.5) 2.363335155536237 5.059128999710083 1.627708911895752 3.431420087814331 1.275416403793989 2.5295644998550415 -5.498694719999999 18.207630719999997 -4.836237383999999 15.210771583999998 -4.832682800000001 21.9930728 DOWN 0.0 1.0 0.0 GO:0060548 6 negative regulation of cell death 321 341 32 32 27 27 22 22 140 319 2066 0.58618 0.50778 0.90534 6.45 25106;83516;29441;25513;81819;24314;24567;24516;192235;63868;24471;25675;29328;25661;361969;24360;24890;29496;114851;246142;50559;170465 rgn;ppargc1a;por;pik3r1;pax8;nqo1;mt1;jun;hyou1;hspd1;hspb1;hmgcr;gpx4;fn1;fga;fabp1;esr1;erbb3;cdkn1a;bmf;acot1;acaa2 RGN_9699;PPARGC1A_33189;POR_9531;PIK3R1_32562;PAX8_9432;NQO1_33055;MT1A_9255;JUN_8938;HYOU1_8857;HSPD1_8849;HSPB1_8847;HMGCR_8810;GPX4_32827;FN1_8655;FGA_8632;FABP1_33091;ESR1_33192;ERBB3_8571;CDKN1A_8271;BMF_8152;ACOT1_7968;ACAA2_7955 41.31739363636364 37.022999999999996 1.63089 27.593194053453267 44.319465752356244 27.097628323026193 29.21761940909091 26.386200000000002 0.663137 20.121306093150757 31.398238509316876 20.03607340833994 69.15960909090909 66.39314999999999 7.6286 43.46691010138422 69.91518573441917 35.36551921093167 16.5 60.28805 77.4407;42.4094;12.4414;18.7324;56.8931;87.2765;12.9315;16.4324;40.1982;42.2579;89.1011;1.63089;45.9204;59.5777;28.5803;33.8478;23.3972;60.9984;6.24967;94.8767;31.2018;26.5872 58.7732;26.2988;8.48981;11.6701;45.1162;60.6992;8.91033;10.5224;29.3844;23.9469;60.3265;0.663137;34.2198;31.0499;22.529;26.4736;18.3088;41.6036;2.44025;73.1342;26.858;21.3695 89.8047;81.7305;79.2355;41.5978;81.5688;197.117;23.4636;39.929;62.3571;102.383;106.138;7.6286;70.4292;105.243;38.8511;46.9257;31.9156;113.972;19.0606;109.848;37.2719;35.0407 10 12 10 25106;81819;24314;63868;29328;24360;29496;246142;50559;170465 RGN_9699;PAX8_9432;NQO1_33055;HSPD1_8849;GPX4_32827;FABP1_33091;ERBB3_8571;BMF_8152;ACOT1_7968;ACAA2_7955 55.73004999999999 51.40675 24.119150787208753 41.21942000000001 37.911699999999996 17.908800553594975 88.4361 85.68674999999999 47.93727896215591 77.4407;56.8931;87.2765;42.2579;45.9204;33.8478;60.9984;94.8767;31.2018;26.5872 58.7732;45.1162;60.6992;23.9469;34.2198;26.4736;41.6036;73.1342;26.858;21.3695 89.8047;81.5688;197.117;102.383;70.4292;46.9257;113.972;109.848;37.2719;35.0407 12 83516;29441;25513;24567;24516;192235;24471;25675;25661;361969;24890;114851 PPARGC1A_33189;POR_9531;PIK3R1_32562;MT1A_9255;JUN_8938;HYOU1_8857;HSPB1_8847;HMGCR_8810;FN1_8655;FGA_8632;ESR1_33192;CDKN1A_8271 29.30684666666666 21.064799999999998 25.12728526113481 19.216118916666666 14.989450000000001 16.44519156560686 53.09586666666667 40.763400000000004 33.27928164459992 42.4094;12.4414;18.7324;12.9315;16.4324;40.1982;89.1011;1.63089;59.5777;28.5803;23.3972;6.24967 26.2988;8.48981;11.6701;8.91033;10.5224;29.3844;60.3265;0.663137;31.0499;22.529;18.3088;2.44025 81.7305;79.2355;41.5978;23.4636;39.929;62.3571;106.138;7.6286;105.243;38.8511;31.9156;19.0606 0 Exp 2,9(0.41);Exp 3,1(0.05);Exp 4,2(0.1);Linear,2(0.1);Poly 2,7(0.32);Power,1(0.05) 2.327029009349721 383.1990736722946 1.522104263305664 344.14306640625 72.97577725919523 1.7549105286598206 29.78693170844185 52.84785556428543 20.809460737873216 37.6257780803086 50.99594340300422 87.32327477881395 CONFLICT 0.45454545454545453 0.5454545454545454 0.0 GO:0042311 8 vasodilation 12 13 2 2 2 2 2 2 160 11 2374 0.95495 0.19842 0.19842 15.38 288001;497840 kng1;cps1 KNG1L1_34113;CPS1_32421 28.17405 28.17405 24.3655 5.386103062976057 30.730979603524226 3.9917825855428872 22.0108 22.0108 19.538 3.4970672970362133 23.67095295154185 2.591768514928382 38.867900000000006 38.867900000000006 32.1467 9.505212195422024 43.38028273127753 7.044562658741617 0.0 24.3655 0.5 28.17405 24.3655;31.9826 19.538;24.4836 32.1467;45.5891 0 2 0 2 288001;497840 KNG1L1_34113;CPS1_32421 28.17405 28.17405 5.386103062976057 22.0108 22.0108 3.4970672970362133 38.867900000000006 38.867900000000006 9.505212195422024 24.3655;31.9826 19.538;24.4836 32.1467;45.5891 0 Exp 2,1(0.5);Linear,1(0.5) 2.085129240790737 4.206887364387512 1.8264755010604858 2.3804118633270264 0.39169215810447877 2.103443682193756 20.709292 35.638808 17.164112000000003 26.857487999999996 25.694348000000012 52.041452 DOWN 0.0 1.0 0.0 GO:0071383 6 cellular response to steroid hormone stimulus 54 60 18 18 12 16 10 10 152 50 2335 0.9989 0.0038629 0.0038629 16.67 79426;286954;294515;25315;116636;24330;140942;25698;312382;25303 zfp36;ugt2b1;foxo3;ephx1;eif4ebp1;egr1;ddit4;ass1;abcg2;abcc2 ZFP36_10204;UGT2B10_33303,UGT2B1_33224;FOXO3_8662;EPHX1_8567;EIF4EBP1_8550;EGR1_8533;DDIT4_8450;ASS1_33159;ABCG2_32656;ABCC2_32541 32.3939541 20.00145 0.348134 32.789605552043255 30.44651839106486 30.563367219599286 19.8376801 13.993425 0.118102 19.474648999343863 18.841939926686074 17.892239369599988 62.146915 34.7331 1.15962 73.66082703050596 51.091543368908404 54.78741879763314 2.0 5.21654 5.0 26.8037 0.348134;47.47345;13.1992;12.4747;83.9001;0.750017;87.5421;26.8037;5.21654;46.2316 0.118102;34.82915;5.6804;7.00435;42.4185;0.186019;53.2453;20.9825;2.73368;31.1788 1.15962;76.47475;32.7581;23.684;107.32;4.70178;245.492;36.7081;11.386;81.7848 5 6 4 286954;25315;116636;312382 UGT2B10_33303,UGT2B1_33224;EPHX1_8567;EIF4EBP1_8550;ABCG2_32656 37.266197500000004 29.974075 36.1511076830668 21.74642 20.91675 19.80997750269461 54.7161875 50.079375 45.02257930350754 47.47345;12.4747;83.9001;5.21654 34.82915;7.00435;42.4185;2.73368 76.47475;23.684;107.32;11.386 6 79426;294515;24330;140942;25698;25303 ZFP36_10204;FOXO3_8662;EGR1_8533;DDIT4_8450;ASS1_33159;ABCC2_32541 29.145791833333334 20.00145 33.458804397438485 18.565186833333332 13.33145 21.032181865661606 67.10073333333334 34.7331 92.06959787763398 0.348134;13.1992;0.750017;87.5421;26.8037;46.2316 0.118102;5.6804;0.186019;53.2453;20.9825;31.1788 1.15962;32.7581;4.70178;245.492;36.7081;81.7848 0 Exp 2,4(0.37);Exp 3,1(0.1);Exp 4,2(0.19);Hill,3(0.28);Linear,1(0.1) 1.9666038155164034 22.593021154403687 1.5074360370635986 4.21828556060791 0.7592832443003539 1.8589661121368408 12.07074602389995 52.717162176100054 7.767167595831866 31.908192604168136 16.491461401373186 107.80236859862683 DOWN 0.4 0.6 0.0 GO:0043032 7 positive regulation of macrophage activation 6 7 2 2 2 2 2 2 160 5 2380 0.99269 0.068343 0.068343 28.57 63868;25423 hspd1;ctsc HSPD1_8849;CTSC_32456 49.24825 49.24825 42.2579 9.885847775734717 50.05537278179191 9.819729725161723 31.107499999999998 31.107499999999998 23.9469 10.126617634728786 31.934280260115607 10.058889278790502 102.63550000000001 102.63550000000001 102.383 0.3570889244931101 102.66465426300577 0.35470065957594393 0.0 42.2579 0.0 42.2579 42.2579;56.2386 23.9469;38.2681 102.383;102.888 1 1 1 63868 HSPD1_8849 42.2579 42.2579 23.9469 23.9469 102.383 102.383 42.2579 23.9469 102.383 1 25423 CTSC_32456 56.2386 56.2386 38.2681 38.2681 102.888 102.888 56.2386 38.2681 102.888 0 Exp 2,1(0.5);Exp 3,1(0.5) 1.8824465053454569 3.825491786003113 1.5736411809921265 2.2518506050109863 0.4795664827883584 1.9127458930015564 35.547164 62.949335999999995 17.072724 45.142275999999995 102.14059999999999 103.13040000000002 CONFLICT 0.5 0.5 0.0 GO:0071495 4 cellular response to endogenous stimulus 313 332 48 47 35 42 31 31 131 301 2084 0.99165 0.014815 0.021621 9.34 79426;286954;246273;24825;83516;29441;24651;25513;81819;25591;58954;24516;81678;81869;294515;314322;25661;24890;29496;25315;116636;24330;140942;25146;497840;29184;25698;65054;25373;312382;25303 zfp36;ugt2b1;trib3;tf;ppargc1a;por;pklr;pik3r1;pax8;parp1;klf6;jun;itpr2;gstm7;foxo3;fos;fn1;esr1;erbb3;ephx1;eif4ebp1;egr1;ddit4;cyp17a1;cps1;cd36;ass1;aqp9;ahsg;abcg2;abcc2 ZFP36_10204;UGT2B10_33303,UGT2B1_33224;TRIB3_10079;TF_10003;PPARGC1A_33189;POR_9531;PKLR_9489;PIK3R1_32562;PAX8_9432;PARP1_9425;KLF6_8969;JUN_8938;ITPR2_8931;GSTM7_8761;FOXO3_8662;FOS_8657;FN1_8655;ESR1_33192;ERBB3_8571;EPHX1_8567;EIF4EBP1_8550;EGR1_8533;DDIT4_8450;CYP17A1_32365;CPS1_32421;CD36_8243;ASS1_33159;AQP9_32709;AHSG_8003;ABCG2_32656;ABCC2_32541 34.874894870967786 27.7316 1.28141E-12 26.435910927967935 36.70854234381553 24.800263148797743 23.886326161290366 21.9372 1.28141E-12 18.210559588404 25.04804304254274 16.91634448642533 60.43814032258067 45.5481 1.28142E-12 49.094059109348045 60.92799187415827 40.40319507504009 15.5 29.771349999999998 0.348134;47.47345;108.064;45.1539;42.4094;12.4414;23.0963;18.7324;56.8931;26.9741;18.9476;16.4324;31.8111;42.3152;13.1992;1.28141E-12;59.5777;23.3972;60.9984;12.4747;83.9001;0.750017;87.5421;49.6922;31.9826;48.1296;26.8037;27.7316;12.402;5.21654;46.2316 0.118102;34.82915;83.8836;28.132;26.2988;8.48981;17.4625;11.6701;45.1162;21.799;11.6941;10.5224;24.7342;31.4035;5.6804;1.28141E-12;31.0499;18.3088;41.6036;7.00435;42.4185;0.186019;53.2453;35.6654;24.4836;37.5433;20.9825;21.9372;10.3013;2.73368;31.1788 1.15962;76.47475;143.428;61.5341;81.7305;79.2355;32.9443;41.5978;81.5688;35.2797;45.5481;39.929;44.3296;64.5991;32.7581;1.28142E-12;105.243;31.9156;113.972;23.684;107.32;4.70178;245.492;81.6409;45.5891;69.1421;36.7081;37.4625;15.4235;11.386;81.7848 12 20 11 286954;24825;81819;25591;81869;29496;25315;116636;25146;29184;312382 UGT2B10_33303,UGT2B1_33224;TF_10003;PAX8_9432;PARP1_9425;GSTM7_8761;ERBB3_8571;EPHX1_8567;EIF4EBP1_8550;CYP17A1_32365;CD36_8243;ABCG2_32656 43.565571818181816 47.47345 22.132988529584885 29.840789090909094 34.82915 14.051227464844795 66.05467727272726 69.1421 32.177969532409634 47.47345;45.1539;56.8931;26.9741;42.3152;60.9984;12.4747;83.9001;49.6922;48.1296;5.21654 34.82915;28.132;45.1162;21.799;31.4035;41.6036;7.00435;42.4185;35.6654;37.5433;2.73368 76.47475;61.5341;81.5688;35.2797;64.5991;113.972;23.684;107.32;81.6409;69.1421;11.386 20 79426;246273;83516;29441;24651;25513;58954;24516;81678;294515;314322;25661;24890;24330;140942;497840;25698;65054;25373;25303 ZFP36_10204;TRIB3_10079;PPARGC1A_33189;POR_9531;PKLR_9489;PIK3R1_32562;KLF6_8969;JUN_8938;ITPR2_8931;FOXO3_8662;FOS_8657;FN1_8655;ESR1_33192;EGR1_8533;DDIT4_8450;CPS1_32421;ASS1_33159;AQP9_32709;AHSG_8003;ABCC2_32541 30.095022550000067 23.24675 27.890084706078078 20.611371550000065 17.88565 19.69483770499241 57.34904500000007 40.763400000000004 56.8537974494331 0.348134;108.064;42.4094;12.4414;23.0963;18.7324;18.9476;16.4324;31.8111;13.1992;1.28141E-12;59.5777;23.3972;0.750017;87.5421;31.9826;26.8037;27.7316;12.402;46.2316 0.118102;83.8836;26.2988;8.48981;17.4625;11.6701;11.6941;10.5224;24.7342;5.6804;1.28141E-12;31.0499;18.3088;0.186019;53.2453;24.4836;20.9825;21.9372;10.3013;31.1788 1.15962;143.428;81.7305;79.2355;32.9443;41.5978;45.5481;39.929;44.3296;32.7581;1.28142E-12;105.243;31.9156;4.70178;245.492;45.5891;36.7081;37.4625;15.4235;81.7848 0 Exp 2,12(0.38);Exp 3,1(0.04);Exp 4,2(0.07);Hill,4(0.13);Linear,6(0.19);Poly 2,6(0.19);Power,1(0.04) 1.9536809387042855 64.31452023983002 1.5074360370635986 4.21828556060791 0.5656815583811142 1.8304733633995056 25.568756528489402 44.181033213446156 17.475728573584675 30.29692374899605 43.1557358270333 77.72054481812809 DOWN 0.3548387096774194 0.6451612903225806 0.0 GO:0010743 6 regulation of macrophage derived foam cell differentiation 11 11 3 3 3 3 3 3 159 8 2377 0.99634 0.028536 0.028536 27.27 25493;24539;29184 nfkbia;lpl;cd36 NFKBIA_9307;LPL_32544;CD36_8243 40.95128366666666 48.1296 0.520151 37.36277899319992 57.03344340224459 24.216202277126555 29.190567333333334 37.5433 0.160202 25.885273294724964 40.74224240549612 15.262598632615545 75.81736333333333 69.1421 2.88499 76.4887770730258 104.80067742080973 61.12773905871783 0.0 0.520151 0.5 24.3248755 0.520151;74.2041;48.1296 0.160202;49.8682;37.5433 2.88499;155.425;69.1421 2 1 2 24539;29184 LPL_32544;CD36_8243 61.16685 61.16685 18.437455766048654 43.70575 43.70575 8.715020367446073 112.28355 112.28355 61.01122369044077 74.2041;48.1296 49.8682;37.5433 155.425;69.1421 1 25493 NFKBIA_9307 0.520151 0.520151 0.160202 0.160202 2.88499 2.88499 0.520151 0.160202 2.88499 0 Exp 2,2(0.67);Exp 4,1(0.34) 1.976621864058879 6.08431601524353 1.559399127960205 2.6703107357025146 0.5754195216779815 1.8546061515808105 -1.3286809317504051 83.23124826508374 -0.10137689598938238 58.48251156265606 -10.73783609153621 162.3725627582029 UP 0.6666666666666666 0.3333333333333333 0.0 GO:1900076 5 regulation of cellular response to insulin stimulus 30 30 3 3 3 3 3 3 159 27 2358 0.8808 0.29728 0.43491 10.0 25513;24539;25373 pik3r1;lpl;ahsg PIK3R1_32562;LPL_32544;AHSG_8003 35.112833333333334 18.7324 12.402 34.00167405060129 48.50493104498445 35.81955091753798 23.946533333333335 11.6701 10.3013 22.459252112288453 32.86129036863144 23.650185908190313 70.81543333333333 41.5978 15.4235 74.43357826789826 99.64989011484045 78.25919651287805 0.5 15.5672 2.0 74.2041 18.7324;74.2041;12.402 11.6701;49.8682;10.3013 41.5978;155.425;15.4235 1 2 1 24539 LPL_32544 74.2041 74.2041 49.8682 49.8682 155.425 155.425 74.2041 49.8682 155.425 2 25513;25373 PIK3R1_32562;AHSG_8003 15.5672 15.5672 4.476268767623311 10.9857 10.9857 0.9678877620881425 28.51065 28.51065 18.508025022811054 18.7324;12.402 11.6701;10.3013 41.5978;15.4235 0 Exp 2,2(0.67);Poly 2,1(0.34) 2.07663047084616 6.664399266242981 1.559399127960205 3.431420087814331 1.0494047006195293 1.6735800504684448 -3.3636829720513077 73.58934963871798 -1.4685029622083938 49.36156962887506 -13.41408970811419 155.0449563747809 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0051050 5 positive regulation of transport 286 308 30 29 21 25 18 18 144 290 2095 0.40304 0.69141 0.80335 5.84 24825;362895;29482;293615;25106;25513;25493;100359982;24539;63868;81869;24957;361969;29496;65210;113936;29184;25373 tf;stac3;slc1a2;sirt3;rgn;pik3r1;nfkbia;mpc2;lpl;hspd1;gstm7;glul;fga;erbb3;cyp2j4;cpb2;cd36;ahsg TF_10003;STAC3_9953;SLC1A2_33059;SIRT3_9828;RGN_9699;PIK3R1_32562;NFKBIA_9307;MPC2_33219;LPL_32544;HSPD1_8849;GSTM7_8761;GLUL_32832;FGA_8632;ERBB3_8571;CYP2J4_32580;CPB2_8369;CD36_8243;AHSG_8003 35.925662833333334 35.4191 0.520151 23.400345084203778 40.203329930238745 22.651841540886775 25.571584000000005 23.237949999999998 0.160202 16.59088215862998 28.50588888007932 15.87911101457455 59.59001444444445 51.56595 2.88499 42.84926603107775 67.46304769632492 44.21759350697536 14.5 62.118849999999995 45.1539;63.2393;13.3235;2.38018;77.4407;18.7324;0.520151;46.8463;74.2041;42.2579;42.3152;26.4669;28.5803;60.9984;17.8395;25.8316;48.1296;12.402 28.132;42.7031;9.10952;0.56209;58.7732;11.6701;0.160202;35.8494;49.8682;23.9469;31.4035;21.0456;22.529;41.6036;14.6501;20.4374;37.5433;10.3013 61.5341;121.52;24.6773;8.82917;89.8047;41.5978;2.88499;69.127;155.425;102.383;64.5991;35.4303;38.8511;113.972;22.6149;34.8042;69.1421;15.4235 10 8 10 24825;293615;25106;100359982;24539;63868;81869;29496;65210;29184 TF_10003;SIRT3_9828;RGN_9699;MPC2_33219;LPL_32544;HSPD1_8849;GSTM7_8761;ERBB3_8571;CYP2J4_32580;CD36_8243 45.756578 46.0001 22.943406602506784 32.233228999999994 33.626450000000006 16.808856498431265 75.74310700000001 69.13454999999999 42.72857086031468 45.1539;2.38018;77.4407;46.8463;74.2041;42.2579;42.3152;60.9984;17.8395;48.1296 28.132;0.56209;58.7732;35.8494;49.8682;23.9469;31.4035;41.6036;14.6501;37.5433 61.5341;8.82917;89.8047;69.127;155.425;102.383;64.5991;113.972;22.6149;69.1421 8 362895;29482;25513;25493;24957;361969;113936;25373 STAC3_9953;SLC1A2_33059;PIK3R1_32562;NFKBIA_9307;GLUL_32832;FGA_8632;CPB2_8369;AHSG_8003 23.637018875000003 22.282 18.50343713030462 17.24452775 16.05375 12.75058724237013 39.39864875 35.11725 35.6784895180217 63.2393;13.3235;18.7324;0.520151;26.4669;28.5803;25.8316;12.402 42.7031;9.10952;11.6701;0.160202;21.0456;22.529;20.4374;10.3013 121.52;24.6773;41.5978;2.88499;35.4303;38.8511;34.8042;15.4235 0 Exp 2,5(0.28);Exp 3,1(0.06);Exp 4,1(0.06);Hill,1(0.06);Linear,6(0.34);Poly 2,4(0.23) 1.999574578340883 37.56502711772919 1.5209722518920898 3.8079800605773926 0.6871955437275719 1.79231196641922 25.115254941784755 46.73607072488191 17.906987483580345 33.23618051641966 39.79466347920936 79.38536540967954 CONFLICT 0.5555555555555556 0.4444444444444444 0.0 GO:0019218 7 regulation of steroid metabolic process 46 49 13 13 8 12 7 7 155 42 2343 0.9892 0.033016 0.033016 14.29 83516;29441;65030;24330;25428;25146;25287 ppargc1a;por;ephx2;egr1;cyp7a1;cyp17a1;acadl PPARGC1A_33189;POR_9531;EPHX2_33282;EGR1_8533;CYP7A1_8430;CYP17A1_32365;ACADL_32776 26.17591385714286 33.4878 0.750017 19.498282475783792 25.463543687806652 19.377112291788855 18.205557428571428 26.2988 0.186019 14.592279343851118 17.73581628172656 13.943239458481083 53.17218285714286 57.2113 4.70178 30.77305537778232 55.15666424081688 32.2802371045179 1.5 9.08134 3.5 36.10855 42.4094;12.4414;38.7293;0.750017;5.72128;49.6922;33.4878 26.2988;8.48981;29.2097;0.186019;0.985273;35.6654;26.6039 81.7305;79.2355;57.2113;4.70178;22.3625;81.6409;45.3228 3 4 3 65030;25146;25287 EPHX2_33282;CYP17A1_32365;ACADL_32776 40.636433333333336 38.7293 8.268827788951304 30.493 29.2097 4.665065886994523 61.39166666666667 57.2113 18.51641693209929 38.7293;49.6922;33.4878 29.2097;35.6654;26.6039 57.2113;81.6409;45.3228 4 83516;29441;24330;25428 PPARGC1A_33189;POR_9531;EGR1_8533;CYP7A1_8430 15.33052425 9.08134 18.677449125789245 8.9899755 4.7375415 12.130271819798448 47.00757 50.799 39.33395769009606 42.4094;12.4414;0.750017;5.72128 26.2988;8.48981;0.186019;0.985273 81.7305;79.2355;4.70178;22.3625 0 Exp 2,2(0.29);Hill,2(0.29);Linear,2(0.29);Poly 2,1(0.15) 2.7268808402181652 20.95776057243347 1.7576230764389038 4.642963409423828 1.3919742139765956 1.9819281101226807 11.731384058475298 40.62044365581041 7.395445611055278 29.015669246087583 30.375184405998233 75.96918130828749 CONFLICT 0.42857142857142855 0.5714285714285714 0.0 GO:0042133 4 neurotransmitter metabolic process 31 35 6 6 5 5 4 4 158 31 2354 0.93248 0.17943 0.27809 11.43 29441;24443;24957;497840 por;hdc;glul;cps1 POR_9531;HDC_8788;GLUL_32832;CPS1_32421 23.86635 25.520699999999998 12.4414 8.239484880541179 23.163433136128997 9.628983707683254 18.7702275 21.05375 8.48981 7.041749123597892 17.701992234209154 8.08003579141883 47.383725 40.5097 29.28 22.273942007403342 54.02079864857027 22.374376646105247 0.5 18.50795 2.5 29.22475 12.4414;24.5745;26.4669;31.9826 8.48981;21.0619;21.0456;24.4836 79.2355;29.28;35.4303;45.5891 1 3 1 24443 HDC_8788 24.5745 24.5745 21.0619 21.0619 29.28 29.28 24.5745 21.0619 29.28 3 29441;24957;497840 POR_9531;GLUL_32832;CPS1_32421 23.630300000000002 26.4669 10.074688532654495 18.006336666666666 21.0456 8.418917439198074 53.41830000000001 45.5891 22.92806503479958 12.4414;26.4669;31.9826 8.48981;21.0456;24.4836 79.2355;35.4303;45.5891 0 Exp 2,2(0.5);Linear,1(0.25);Poly 2,1(0.25) 3.4982285663821973 23.683735013008118 1.8264755010604858 17.513065338134766 7.731364352245375 2.172097086906433 15.791654817069645 31.941045182930356 11.869313358874068 25.671141641125935 25.555261832744744 69.21218816725526 DOWN 0.25 0.75 0.0 GO:0019318 5 hexose metabolic process 48 54 8 8 6 6 4 4 158 50 2335 0.74264 0.45318 0.77446 7.41 83516;25513;25685;114860 ppargc1a;pik3r1;igfbp1;gale PPARGC1A_33189;PIK3R1_32562;IGFBP1_32306;GALE_8680 45.328925 45.71765 18.7324 21.573062109240947 43.0092853561075 20.57580442007747 28.485274999999998 29.49355 11.6701 13.218616975658492 26.755289610593117 12.552731833065874 75.34847500000001 85.3169 41.5978 22.76249362414335 73.77522509598057 22.01793552683517 1.5 45.71765 42.4094;18.7324;49.0259;71.148 26.2988;11.6701;32.6883;43.2839 81.7305;41.5978;89.1623;88.9033 0 4 0 4 83516;25513;25685;114860 PPARGC1A_33189;PIK3R1_32562;IGFBP1_32306;GALE_8680 45.328925 45.71765 21.573062109240947 28.485274999999998 29.49355 13.218616975658492 75.34847500000001 85.3169 22.76249362414335 42.4094;18.7324;49.0259;71.148 26.2988;11.6701;32.6883;43.2839 81.7305;41.5978;89.1623;88.9033 0 Exp 2,2(0.5);Poly 2,2(0.5) 2.153724345774449 9.236291646957397 1.6735800504684448 3.9562058448791504 1.1004196246350482 1.8032528758049011 24.18732413294389 66.47052586705611 15.531030363854684 41.43951963614532 53.04123124833953 97.65571875166049 DOWN 0.0 1.0 0.0 GO:0045664 8 regulation of neuron differentiation 157 165 5 5 3 4 3 3 159 162 2223 0.0048761 0.99887 0.0080203 1.82 24471;294515;25661 hspb1;foxo3;fn1 HSPB1_8847;FOXO3_8662;FN1_8655 53.959333333333326 59.5777 13.1992 38.26158829561751 66.16002877632145 26.955029421309238 32.35226666666667 31.0499 5.6804 27.34631932277785 39.53011290825097 21.481948756181048 81.3797 105.243 32.7581 42.10991861984537 98.7111199666953 26.130733127655446 89.1011;13.1992;59.5777 60.3265;5.6804;31.0499 106.138;32.7581;105.243 0 3 0 3 24471;294515;25661 HSPB1_8847;FOXO3_8662;FN1_8655 53.959333333333326 59.5777 38.26158829561751 32.35226666666667 31.0499 27.34631932277785 81.3797 105.243 42.10991861984537 89.1011;13.1992;59.5777 60.3265;5.6804;31.0499 106.138;32.7581;105.243 0 Exp 4,1(0.34);Poly 2,1(0.34);Power,1(0.34) 1.8175889484986498 5.464892506599426 1.6973176002502441 1.9883413314819336 0.15007281172478393 1.7792335748672485 10.662270261222446 97.25639640544422 1.4069932148581934 63.29754011847514 33.72784121258692 129.03155878741308 DOWN 0.0 1.0 0.0 GO:0010629 7 negative regulation of gene expression 355 375 29 29 22 26 20 20 142 355 2030 0.22417 0.8408 0.42368 5.33 79426;24522;246273;29573;25591;24516;25112;294515;25661;308441;24890;116636;24330;113936;25695;114851;29184;79431;155423;25303 zfp36;zfp354a;trib3;slc37a4;parp1;jun;gadd45a;foxo3;fn1;exosc5;esr1;eif4ebp1;egr1;cpb2;cebpd;cdkn1a;cd36;bhlhe40;anxa7;abcc2 ZFP36_10204;ZFP354A_10203;TRIB3_10079;SLC37A4_9871;PARP1_9425;JUN_8938;GADD45A_8678;FOXO3_8662;FN1_8655;EXOSC5_32543;ESR1_33192;EIF4EBP1_8550;EGR1_8533;CPB2_8369;CEBPD_8283;CDKN1A_8271;CD36_8243;BHLHE40_8141;ANXA7_8051;ABCC2_32541 40.362204199999994 33.345349999999996 0.306936 36.117318803062666 42.21630094262203 37.76399824970789 26.605552760000002 22.24505 0.0732342 25.478602239310472 27.795453883297522 27.551353094981096 58.40693299999998 49.9812 1.15962 44.591725883821745 59.616009362145284 45.7489869140576 17.5 103.7795 0.348134;0.834827;108.064;39.7166;26.9741;16.4324;102.919;13.1992;59.5777;41.9329;23.3972;83.9001;0.750017;25.8316;0.306936;6.24967;48.1296;57.8085;104.64;46.2316 0.118102;0.27095;83.8836;22.6911;21.799;10.5224;89.5012;5.6804;31.0499;31.7336;18.3088;42.4185;0.186019;20.4374;0.0732342;2.44025;37.5433;38.3491;43.9254;31.1788 1.15962;2.99857;143.428;60.0334;35.2797;39.929;115.437;32.7581;105.243;62.1373;31.9156;107.32;4.70178;34.8042;1.73689;19.0606;69.1421;110.58;108.689;81.7848 5 15 5 25591;308441;116636;29184;155423 PARP1_9425;EXOSC5_32543;EIF4EBP1_8550;CD36_8243;ANXA7_8051 61.11533999999999 48.1296 32.07709865625321 35.48396 37.5433 9.01290693744254 76.51361999999999 69.1421 31.406775420552183 26.9741;41.9329;83.9001;48.1296;104.64 21.799;31.7336;42.4185;37.5433;43.9254 35.2797;62.1373;107.32;69.1421;108.689 15 79426;24522;246273;29573;24516;25112;294515;25661;24890;24330;113936;25695;114851;79431;25303 ZFP36_10204;ZFP354A_10203;TRIB3_10079;SLC37A4_9871;JUN_8938;GADD45A_8678;FOXO3_8662;FN1_8655;ESR1_33192;EGR1_8533;CPB2_8369;CEBPD_8283;CDKN1A_8271;BHLHE40_8141;ABCC2_32541 33.444492266666664 23.3972 35.65480161668499 23.646083679999997 18.3088 28.64011530968704 52.371370666666664 34.8042 47.54606442975582 0.348134;0.834827;108.064;39.7166;16.4324;102.919;13.1992;59.5777;23.3972;0.750017;25.8316;0.306936;6.24967;57.8085;46.2316 0.118102;0.27095;83.8836;22.6911;10.5224;89.5012;5.6804;31.0499;18.3088;0.186019;20.4374;0.0732342;2.44025;38.3491;31.1788 1.15962;2.99857;143.428;60.0334;39.929;115.437;32.7581;105.243;31.9156;4.70178;34.8042;1.73689;19.0606;110.58;81.7848 0 Exp 2,7(0.35);Exp 3,2(0.1);Exp 4,2(0.1);Hill,4(0.2);Poly 2,4(0.2);Power,1(0.05) 1.9859387947251395 41.907435297966 1.522104263305664 4.591650485992432 0.8424939307721894 1.8338178992271423 24.533091318298837 56.19131708170118 15.43906299055979 37.77204252944021 38.8637474591886 77.9501185408114 DOWN 0.25 0.75 0.0 GO:0051593 6 response to folic acid 7 7 2 2 2 2 2 2 160 5 2380 0.99269 0.068343 0.068343 28.57 24522;312382 zfp354a;abcg2 ZFP354A_10203;ABCG2_32656 3.0256835 3.0256835 0.834827 3.0983389755132515 2.811225313957977 3.083459060870378 1.502315 1.502315 0.27095 1.7414130832315462 1.3817793536645895 1.7330498672499328 7.192285 7.192285 2.99857 5.930808629727482 6.781771343958528 5.902325650017703 0.0 0.834827 0.0 0.834827 0.834827;5.21654 0.27095;2.73368 2.99857;11.386 1 1 1 312382 ABCG2_32656 5.21654 5.21654 2.73368 2.73368 11.386 11.386 5.21654 2.73368 11.386 1 24522 ZFP354A_10203 0.834827 0.834827 0.27095 0.27095 2.99857 2.99857 0.834827 0.27095 2.99857 0 Exp 4,1(0.5);Hill,1(0.5) 2.6308970736586366 6.09908652305603 1.5074360370635986 4.591650485992432 2.1808689514711084 3.049543261528015 -1.2683952399999994 7.31976224 -0.9111603999999998 3.9157903999999997 -1.027396399999998 15.411966399999997 CONFLICT 0.5 0.5 0.0 GO:0043269 6 regulation of ion transport 174 184 14 13 9 11 7 7 155 177 2208 0.087569 0.95711 0.159 3.8 24825;362895;170698;25106;83516;81869;25303 tf;stac3;slco1a2;rgn;ppargc1a;gstm7;abcc2 TF_10003;STAC3_9953;SLCO1A2_9886;RGN_9699;PPARGC1A_33189;GSTM7_8761;ABCC2_32541 60.141014285714284 46.2316 42.3152 23.45230471243206 54.51961337469734 17.32491747725847 42.68564285714286 31.4035 26.2988 20.06008015145645 37.72795995157385 14.935881996264778 89.91217142857144 81.7848 61.5341 26.013982182646455 84.24831962772397 23.401961194026885 45.1539;63.2393;104.197;77.4407;42.4094;42.3152;46.2316 28.132;42.7031;80.3101;58.7732;26.2988;31.4035;31.1788 61.5341;121.52;128.412;89.8047;81.7305;64.5991;81.7848 3 4 3 24825;25106;81869 TF_10003;RGN_9699;GSTM7_8761 54.96993333333334 45.1539 19.511946862456668 39.436233333333334 31.4035 16.82600332709267 71.97930000000001 64.5991 15.513130571228997 45.1539;77.4407;42.3152 28.132;58.7732;31.4035 61.5341;89.8047;64.5991 4 362895;170698;83516;25303 STAC3_9953;SLCO1A2_9886;PPARGC1A_33189;ABCC2_32541 64.019325 54.73545 28.27393397098881 45.1227 36.94095 24.445716334632817 103.36182500000001 101.6524 25.104533561141885 63.2393;104.197;42.4094;46.2316 42.7031;80.3101;26.2988;31.1788 121.52;128.412;81.7305;81.7848 0 Exp 2,2(0.29);Linear,2(0.29);Poly 2,3(0.43) 1.8770894841291277 13.380939960479736 1.5806894302368164 2.879150867462158 0.43606265264937455 1.7576230764389038 42.767303822401345 77.51472474902721 27.824927516125392 57.54635819816034 70.64074373816206 109.1835991189808 CONFLICT 0.42857142857142855 0.5714285714285714 0.0 GO:0006085 8 acetyl-CoA biosynthetic process 6 6 3 3 3 2 2 2 160 4 2381 0.99562 0.050905 0.050905 33.33 298490;100359982 ppcs;mpc2 PPCS_9540;MPC2_33219 33.5908 33.5908 20.3353 18.746107876036557 33.923704062953455 18.740195043535135 26.30685 26.30685 16.7643 13.495203629623386 26.54650551400826 13.490947019175909 47.399049999999995 47.399049999999995 25.6711 30.7279615725645 47.944734646723965 30.718269465216622 0.0 20.3353 0.0 20.3353 20.3353;46.8463 16.7643;35.8494 25.6711;69.127 2 0 2 298490;100359982 PPCS_9540;MPC2_33219 33.5908 33.5908 18.746107876036557 26.30685 26.30685 13.495203629623386 47.399049999999995 47.399049999999995 30.7279615725645 20.3353;46.8463 16.7643;35.8494 25.6711;69.127 0 0 Exp 2,2(1) 2.1351960461927337 4.293951869010925 1.9223796129226685 2.371572256088257 0.3176271640414966 2.1469759345054626 7.610020000000006 59.57158 7.603451999999997 45.010248000000004 4.81226800000001 89.98583199999999 UP 1.0 0.0 0.0 GO:1990643 7 cellular response to granulocyte colony-stimulating factor 1 1 1 1 1 1 1 1 161 0 2385 1.0 0.063604 0.063604 100.0 361969 fga FGA_8632 28.5803 28.5803 28.5803 28.5803 22.529 22.529 22.529 22.529 38.8511 38.8511 38.8511 38.8511 0.0 28.5803 0.0 28.5803 28.5803 22.529 38.8511 0 1 0 1 361969 FGA_8632 28.5803 28.5803 22.529 22.529 38.8511 38.8511 28.5803 22.529 38.8511 0 Linear,1(1) 1.541895866394043 1.541895866394043 1.541895866394043 1.541895866394043 0.0 1.541895866394043 28.5803 28.5803 22.529 22.529 38.8511 38.8511 DOWN 0.0 1.0 0.0 GO:0042178 5 xenobiotic catabolic process 6 15 3 3 3 3 3 3 159 12 2373 0.98762 0.065323 0.065323 20.0 286954;81869;25303 ugt2b1;gstm7;abcc2 UGT2B10_33303,UGT2B1_33224;GSTM7_8761;ABCC2_32541 45.340083333333325 46.2316 42.3152 2.692208617628729 45.67651326542611 2.7280387772352492 32.470483333333334 31.4035 31.1788 2.0457526379875883 33.009141989299465 2.157841178729426 74.28621666666668 76.47475 64.5991 8.799393714105221 74.14940517535351 7.979279586690089 0.0 42.3152 0.5 44.273399999999995 47.47345;42.3152;46.2316 34.82915;31.4035;31.1788 76.47475;64.5991;81.7848 3 1 2 286954;81869 UGT2B10_33303,UGT2B1_33224;GSTM7_8761 44.894324999999995 44.894324999999995 3.647433554055609 33.116325 33.116325 2.4223003449715863 70.536925 70.536925 8.397352645998092 47.47345;42.3152 34.82915;31.4035 76.47475;64.5991 1 25303 ABCC2_32541 46.2316 46.2316 31.1788 31.1788 81.7848 81.7848 46.2316 31.1788 81.7848 0 Exp 2,3(0.75);Linear,1(0.25) 1.7543152250538656 7.024123907089233 1.6419988870620728 1.8589661121368408 0.08929664394776883 1.76157945394516 42.293562487932505 48.38660417873416 30.15549629430775 34.78547037235892 64.3287653007602 84.24366803257313 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0006091 4 generation of precursor metabolites and energy 77 85 14 14 13 12 11 11 151 74 2311 0.99348 0.017073 0.020475 12.94 29573;293615;192280;83516;29441;303612;24651;295143;83842;50681;24158 slc37a4;sirt3;ppp1r3b;ppargc1a;por;polg2;pklr;etfdh;crot;acox1;acadm SLC37A4_9871;SIRT3_9828;PPP1R3B_9545;PPARGC1A_33189;POR_9531;POLG2_9521;PKLR_9489;ETFDH_8575;CROT_8384;ACOX1_7973;ACADM_7957 25.491916363636367 23.0963 2.38018 18.313206050622195 27.443045418335316 17.357144829754343 17.16249818181818 16.2815 0.56209 11.586751947371459 18.332170038784863 11.09218803754506 48.60987909090909 33.4539 8.82917 37.81215332029915 52.31297237128838 34.23841575251295 3.5 15.282250000000001 7.5 37.92885 39.7166;2.38018;36.1411;42.4094;12.4414;63.7758;23.0963;18.1231;7.4229;23.1906;11.7137 22.6911;0.56209;27.0588;26.2988;8.48981;40.9553;17.4625;14.869;5.75707;16.2815;8.36151 60.0334;8.82917;53.6244;81.7305;79.2355;132.567;32.9443;23.0103;10.316;33.4539;18.9642 5 6 5 293615;295143;83842;50681;24158 SIRT3_9828;ETFDH_8575;CROT_8384;ACOX1_7973;ACADM_7957 12.566096000000002 11.7137 8.286922038614819 9.166234 8.36151 6.508644716247001 18.914713999999996 18.9642 10.047640062720198 2.38018;18.1231;7.4229;23.1906;11.7137 0.56209;14.869;5.75707;16.2815;8.36151 8.82917;23.0103;10.316;33.4539;18.9642 6 29573;192280;83516;29441;303612;24651 SLC37A4_9871;PPP1R3B_9545;PPARGC1A_33189;POR_9531;POLG2_9521;PKLR_9489 36.26343333333333 37.92885 17.59264177827385 23.826051666666668 24.49495 10.834754340824558 73.35585 69.63445 34.0898122540298 39.7166;36.1411;42.4094;12.4414;63.7758;23.0963 22.6911;27.0588;26.2988;8.48981;40.9553;17.4625 60.0334;53.6244;81.7305;79.2355;132.567;32.9443 0 Exp 2,4(0.37);Hill,1(0.1);Linear,1(0.1);Poly 2,4(0.37);Power,1(0.1) 2.274322235443433 28.68175756931305 1.5209722518920898 5.973292827606201 1.690765421089877 1.8798987865447998 14.669503179125005 36.314329548147725 10.31516535029384 24.009831013342527 26.264324440500562 70.95543374131762 CONFLICT 0.45454545454545453 0.5454545454545454 0.0 GO:1901605 7 alpha-amino acid metabolic process 67 72 9 9 6 9 6 6 156 66 2319 0.82983 0.30697 0.45893 8.33 24443;24957;497840;81718;25698;296925 hdc;glul;cps1;cdo1;ass1;aass HDC_8788;GLUL_32832;CPS1_32421;CDO1_8275;ASS1_33159;AASS_7936 26.709316666666666 26.6353 22.9638 3.066975034405496 26.835590885717114 3.2760319817713524 21.306299999999997 21.05375 18.5144 1.9141147008473884 21.19901087121337 2.155535260053001 35.67581666666667 36.0692 29.28 5.901695081386945 36.34290760127897 5.788791579946023 2.5 26.6353 24.5745;26.4669;31.9826;22.9638;26.8037;27.4644 21.0619;21.0456;24.4836;18.5144;20.9825;21.7498 29.28;35.4303;45.5891;30.0179;36.7081;37.0295 2 4 2 24443;296925 HDC_8788;AASS_7936 26.01945 26.01945 2.043467886951038 21.40585 21.40585 0.4864187547781619 33.15475 33.15475 5.479724000805165 24.5745;27.4644 21.0619;21.7498 29.28;37.0295 4 24957;497840;81718;25698 GLUL_32832;CPS1_32421;CDO1_8275;ASS1_33159 27.05425 26.6353 3.716098772009889 21.256525 21.01405 2.4530825252798523 36.936350000000004 36.0692 6.456400380759109 26.4669;31.9826;22.9638;26.8037 21.0456;24.4836;18.5144;20.9825 35.4303;45.5891;30.0179;36.7081 0 Exp 2,3(0.5);Linear,3(0.5) 2.8631410179628674 27.52101981639862 1.8264755010604858 17.513065338134766 6.335383306223638 1.9688915610313416 24.255225529871527 29.163407803461805 19.774689253429536 22.837910746570465 30.953477088148865 40.39815624518446 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0010810 6 regulation of cell-substrate adhesion 67 71 7 7 4 5 4 4 158 67 2318 0.52464 0.67229 1.0 5.63 85253;25513;25661;29184 plg;pik3r1;fn1;cd36 PLG_9501;PIK3R1_32562;FN1_8655;CD36_8243 49.306349999999995 53.85365 18.7324 22.383135514712873 54.675401155876266 17.478341589487922 31.624724999999998 34.2966 11.6701 14.68587394933763 34.85696586824347 11.50721152543227 91.64047500000001 87.19255 41.5978 47.149494922524504 99.48266271129819 42.16331726032541 2.5 65.1817 70.7857;18.7324;59.5777;48.1296 46.2356;11.6701;31.0499;37.5433 150.579;41.5978;105.243;69.1421 1 3 1 29184 CD36_8243 48.1296 48.1296 37.5433 37.5433 69.1421 69.1421 48.1296 37.5433 69.1421 3 85253;25513;25661 PLG_9501;PIK3R1_32562;FN1_8655 49.6986 59.5777 27.39678763705701 29.651866666666667 31.0499 17.32510665085018 99.13993333333333 105.243 54.74633371663651 70.7857;18.7324;59.5777 46.2356;11.6701;31.0499 150.579;41.5978;105.243 0 Exp 2,1(0.25);Linear,1(0.25);Poly 2,1(0.25);Power,1(0.25) 1.8662128074545588 7.648593425750732 1.5254690647125244 2.6703107357025146 0.5160465882568256 1.7264068126678467 27.370877195581397 71.2418228044186 17.232568529649136 46.01688147035087 45.433969975925955 137.84698002407404 DOWN 0.25 0.75 0.0 GO:0032990 5 cell part morphogenesis 59 63 3 3 3 3 3 3 159 60 2325 0.42324 0.77611 0.7956 4.76 308843;303612;29496 tsku;polg2;erbb3 TSKU_10094;POLG2_9521;ERBB3_8571 42.05278666666666 60.9984 1.38416 35.247430883747164 51.87513706120425 27.837186898268534 27.699822666666666 40.9553 0.540568 23.5228380251861 34.49216668704055 18.694231573234717 83.54924 113.972 4.10872 69.42291170537865 101.51100018171306 54.5687177717471 1.38416;63.7758;60.9984 0.540568;40.9553;41.6036 4.10872;132.567;113.972 1 2 1 29496 ERBB3_8571 60.9984 60.9984 41.6036 41.6036 113.972 113.972 60.9984 41.6036 113.972 2 308843;303612 TSKU_10094;POLG2_9521 32.57998 32.57998 44.11755173334984 20.747934 20.747934 28.57753105703696 68.33786 68.33786 90.83372088756026 1.38416;63.7758 0.540568;40.9553 4.10872;132.567 0 Exp 2,1(0.34);Hill,1(0.34);Linear,1(0.34) 1.9473507512437138 6.1261619329452515 1.5504547357559204 2.9744045734405518 0.8078394655089555 1.6013026237487793 2.1665637970773304 81.939009536256 1.0812256094141475 54.318419723919185 4.989819948385147 162.10866005161483 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0045844 7 positive regulation of striated muscle tissue development 30 32 2 2 2 2 2 2 160 30 2355 0.66694 0.6142 1.0 6.25 25675;29496 hmgcr;erbb3 HMGCR_8810;ERBB3_8571 31.314645 31.314645 1.63089 41.979168903160165 51.826087121295274 30.344885994341105 21.1333685 21.1333685 0.663137 28.949279012216948 35.27827599643249 20.926154428416115 60.8003 60.8003 7.6286 75.19613927443349 97.54188633369922 54.35596590206681 0.5 31.314645 1.63089;60.9984 0.663137;41.6036 7.6286;113.972 1 1 1 29496 ERBB3_8571 60.9984 60.9984 41.6036 41.6036 113.972 113.972 60.9984 41.6036 113.972 1 25675 HMGCR_8810 1.63089 1.63089 0.663137 0.663137 7.6286 7.6286 1.63089 0.663137 7.6286 0 Exp 4,1(0.5);Linear,1(0.5) 1.7450815094872434 3.503072738647461 1.6013026237487793 1.9017701148986816 0.2124626005182049 1.7515363693237305 -26.865514799999985 89.49480479999998 -18.98828524 61.25502224 -43.416231999999994 165.01683199999997 CONFLICT 0.5 0.5 0.0 GO:0098771 7 inorganic ion homeostasis 152 161 20 20 16 15 12 12 150 149 2236 0.7802 0.32456 0.50634 7.45 24825;29573;25106;24567;288001;81678;81869;304929;24890;29184;155423;25303 tf;slc37a4;rgn;mt1;kng1;itpr2;gstm7;f5;esr1;cd36;anxa7;abcc2 TF_10003;SLC37A4_9871;RGN_9699;MT1A_9255;KNG1L1_34113;ITPR2_8931;GSTM7_8761;F5_33079;ESR1_33192;CD36_8243;ANXA7_8051;ABCC2_32541 42.22848333333333 41.0159 10.6089 26.69892309741192 47.74967418019906 24.079057104512128 27.310826666666674 26.433100000000003 2.59129 15.142000529059624 31.07959575100402 13.15035078759571 58.745875000000005 60.78375 23.4636 26.06396951861899 64.90055659856817 22.17300896273106 7.5 45.692750000000004 45.1539;39.7166;77.4407;12.9315;24.3655;31.8111;42.3152;10.6089;23.3972;48.1296;104.64;46.2316 28.132;22.6911;58.7732;8.91033;19.538;24.7342;31.4035;2.59129;18.3088;37.5433;43.9254;31.1788 61.5341;60.0334;89.8047;23.4636;32.1467;44.3296;64.5991;37.5078;31.9156;69.1421;108.689;81.7848 5 7 5 24825;25106;81869;29184;155423 TF_10003;RGN_9699;GSTM7_8761;CD36_8243;ANXA7_8051 63.53588 48.1296 26.965072835188135 39.95548 37.5433 12.130710040925067 78.7538 69.1421 20.046801284244825 45.1539;77.4407;42.3152;48.1296;104.64 28.132;58.7732;31.4035;37.5433;43.9254 61.5341;89.8047;64.5991;69.1421;108.689 7 29573;24567;288001;81678;304929;24890;25303 SLC37A4_9871;MT1A_9255;KNG1L1_34113;ITPR2_8931;F5_33079;ESR1_33192;ABCC2_32541 27.00891428571429 24.3655 13.173357523353525 18.27893142857143 19.538 9.686788813551562 44.4545 37.5078 20.140545759983755 39.7166;12.9315;24.3655;31.8111;10.6089;23.3972;46.2316 22.6911;8.91033;19.538;24.7342;2.59129;18.3088;31.1788 60.0334;23.4636;32.1467;44.3296;37.5078;31.9156;81.7848 0 Exp 2,3(0.25);Exp 3,1(0.09);Hill,1(0.09);Linear,3(0.25);Poly 2,4(0.34) 1.9491845739609024 23.73605990409851 1.5461770296096802 2.6703107357025146 0.3639947492219078 1.846718668937683 27.122145504716727 57.33482116194993 18.743433346775063 35.878219986558264 43.99879597862963 73.49295402137038 CONFLICT 0.4166666666666667 0.5833333333333334 0.0 GO:0010033 4 response to organic substance 795 856 106 105 81 98 75 75 87 781 1604 0.9998 3.6395E-4 5.599E-4 8.76 79426;24522;312688;286954;246273;24825;170698;29573;25351;29482;24648;246074;83516;29441;298199;24651;25513;81819;25591;24314;81525;25493;24552;24539;89783;58954;24516;81678;54404;494344;63868;24471;29540;24464;25675;113965;81869;29328;24957;24384;294515;314322;25661;25256;246186;361969;24890;29496;25315;116636;24330;116663;140942;25428;65210;25146;25423;83842;497840;113936;367313;81718;114851;29184;54232;25698;65054;155423;25028;25373;192272;24158;312382;140668;25303 zfp36;zfp354a;usp18;ugt2b1;trib3;tf;slco1a2;slc37a4;slc2a2;slc1a2;serpina1;scd;ppargc1a;por;plin2;pklr;pik3r1;pax8;parp1;nqo1;nfkbib;nfkbia;me1;lpl;laptm5;klf6;jun;itpr2;itih4;ier2;hspd1;hspb1;hsd17b7;hp;hmgcr;hadh;gstm7;gpx4;glul;gc;foxo3;fos;fn1;fmo1;fgl1;fga;esr1;erbb3;ephx1;eif4ebp1;egr1;dusp6;ddit4;cyp7a1;cyp2j4;cyp17a1;ctsc;crot;cps1;cpb2;col6a3;cdo1;cdkn1a;cd36;car3;ass1;aqp9;anxa7;ampd1;ahsg;acot2;acadm;abcg2;abcc3;abcc2 ZFP36_10204;ZFP354A_10203;USP18_10138;UGT2B10_33303,UGT2B1_33224;TRIB3_10079;TF_10003;SLCO1A2_9886;SLC37A4_9871;SLC2A2_9863;SLC1A2_33059;SERPINA1_9807;SCD1_9787;PPARGC1A_33189;POR_9531;PLIN2_9502;PKLR_9489;PIK3R1_32562;PAX8_9432;PARP1_9425;NQO1_33055;NFKBIB_9308;NFKBIA_9307;ME1_9215;LPL_32544;LAPTM5_32639;KLF6_8969;JUN_8938;ITPR2_8931;ITIH4_32725;IER2_32643;HSPD1_8849;HSPB1_8847;HSD17B7_8834;HP_8823;HMGCR_8810;HADH_8776;GSTM7_8761;GPX4_32827;GLUL_32832;GC_32893;FOXO3_8662;FOS_8657;FN1_8655;FMO1_32787;FGL1_8640;FGA_8632;ESR1_33192;ERBB3_8571;EPHX1_8567;EIF4EBP1_8550;EGR1_8533;DUSP6_8506;DDIT4_8450;CYP7A1_8430;CYP2J4_32580;CYP17A1_32365;CTSC_32456;CROT_8384;CPS1_32421;CPB2_8369;COL6A3_33029;CDO1_8275;CDKN1A_8271;CD36_8243;CAR3_8196;ASS1_33159;AQP9_32709;ANXA7_8051;AMPD1_32743;AHSG_8003;ACOT2_7969;ACADM_7957;ABCG2_32656;ABCC3_7941;ABCC2_32541 39.268425373333336 31.9826 1.28141E-12 29.65405950722664 40.375948955494266 26.72226668343952 26.641359533333354 24.2439 1.28141E-12 19.76878954889075 27.13066696924769 17.376778762490368 67.76742173333335 46.9856 1.28142E-12 63.479941708200045 68.68314326315279 55.2673922319192 41.5 40.98725 0.348134;0.834827;108.883;47.47345;108.064;45.1539;104.197;39.7166;29.7555;13.3235;15.797;105.46;42.4094;12.4414;25.6517;23.0963;18.7324;56.8931;26.9741;87.2765;30.5572;0.520151;80.7944;74.2041;38.674;18.9476;16.4324;31.8111;57.1163;49.6814;42.2579;89.1011;0.977494;64.9285;1.63089;33.3125;42.3152;45.9204;26.4669;42.356;13.1992;1.28141E-12;59.5777;65.2792;15.4757;28.5803;23.3972;60.9984;12.4747;83.9001;0.750017;62.3934;87.5421;5.72128;17.8395;49.6922;56.2386;7.4229;31.9826;25.8316;63.132;22.9638;6.24967;48.1296;53.9626;26.8037;27.7316;104.64;60.9045;12.402;8.54905;11.7137;5.21654;37.7175;46.2316 0.118102;0.27095;73.1414;34.82915;83.8836;28.132;80.3101;22.6911;23.3399;9.10952;13.013;63.7532;26.2988;8.48981;20.9252;17.4625;11.6701;45.1162;21.799;60.6992;24.2439;0.160202;59.856;49.8682;24.6273;11.6941;10.5224;24.7342;39.6402;33.4626;23.9469;60.3265;0.322682;41.6103;0.663137;25.7336;31.4035;34.2198;21.0456;26.3722;5.6804;1.28141E-12;31.0499;39.7882;10.2138;22.529;18.3088;41.6036;7.00435;42.4185;0.186019;39.0875;53.2453;0.985273;14.6501;35.6654;38.2681;5.75707;24.4836;20.4374;42.651;18.5144;2.44025;37.5433;28.5034;20.9825;21.9372;43.9254;50.0633;10.3013;7.19676;8.36151;2.73368;30.9007;31.1788 1.15962;2.99857;138.144;76.47475;143.428;61.5341;128.412;60.0334;40.808;24.6773;19.9134;422.699;81.7305;79.2355;33.0375;32.9443;41.5978;81.5688;35.2797;197.117;41.2611;2.88499;94.0621;155.425;71.0786;45.5481;39.929;44.3296;101.869;89.4404;102.383;106.138;5.49472;136.455;7.6286;46.9856;64.5991;70.4292;35.4303;78.7583;32.7581;1.28142E-12;105.243;82.9415;30.4106;38.8511;31.9156;113.972;23.684;107.32;4.70178;133.304;245.492;22.3625;22.6149;81.6409;102.888;10.316;45.5891;34.8042;121.149;30.0179;19.0606;69.1421;77.0288;36.7081;37.4625;108.689;82.6625;15.4235;10.4125;18.9642;11.386;48.9329;81.7848 29 47 28 312688;286954;24825;246074;298199;81819;25591;24314;81525;24539;63868;113965;81869;29328;25256;29496;25315;116636;65210;25146;83842;29184;155423;25028;192272;24158;312382;140668 USP18_10138;UGT2B10_33303,UGT2B1_33224;TF_10003;SCD1_9787;PLIN2_9502;PAX8_9432;PARP1_9425;NQO1_33055;NFKBIB_9308;LPL_32544;HSPD1_8849;HADH_8776;GSTM7_8761;GPX4_32827;FMO1_32787;ERBB3_8571;EPHX1_8567;EIF4EBP1_8550;CYP2J4_32580;CYP17A1_32365;CROT_8384;CD36_8243;ANXA7_8051;AMPD1_32743;ACOT2_7969;ACADM_7957;ABCG2_32656;ABCC3_7941 48.100390714285716 45.53715 30.195209272659625 32.33654 32.81165 18.106871771896337 82.84344107142856 69.78565 80.83019888668657 108.883;47.47345;45.1539;105.46;25.6517;56.8931;26.9741;87.2765;30.5572;74.2041;42.2579;33.3125;42.3152;45.9204;65.2792;60.9984;12.4747;83.9001;17.8395;49.6922;7.4229;48.1296;104.64;60.9045;8.54905;11.7137;5.21654;37.7175 73.1414;34.82915;28.132;63.7532;20.9252;45.1162;21.799;60.6992;24.2439;49.8682;23.9469;25.7336;31.4035;34.2198;39.7882;41.6036;7.00435;42.4185;14.6501;35.6654;5.75707;37.5433;43.9254;50.0633;7.19676;8.36151;2.73368;30.9007 138.144;76.47475;61.5341;422.699;33.0375;81.5688;35.2797;197.117;41.2611;155.425;102.383;46.9856;64.5991;70.4292;82.9415;113.972;23.684;107.32;22.6149;81.6409;10.316;69.1421;108.689;82.6625;10.4125;18.9642;11.386;48.9329 47 79426;24522;246273;170698;29573;25351;29482;24648;83516;29441;24651;25513;25493;24552;89783;58954;24516;81678;54404;494344;24471;29540;24464;25675;24957;24384;294515;314322;25661;246186;361969;24890;24330;116663;140942;25428;25423;497840;113936;367313;81718;114851;54232;25698;65054;25373;25303 ZFP36_10204;ZFP354A_10203;TRIB3_10079;SLCO1A2_9886;SLC37A4_9871;SLC2A2_9863;SLC1A2_33059;SERPINA1_9807;PPARGC1A_33189;POR_9531;PKLR_9489;PIK3R1_32562;NFKBIA_9307;ME1_9215;LAPTM5_32639;KLF6_8969;JUN_8938;ITPR2_8931;ITIH4_32725;IER2_32643;HSPB1_8847;HSD17B7_8834;HP_8823;HMGCR_8810;GLUL_32832;GC_32893;FOXO3_8662;FOS_8657;FN1_8655;FGL1_8640;FGA_8632;ESR1_33192;EGR1_8533;DUSP6_8506;DDIT4_8450;CYP7A1_8430;CTSC_32456;CPS1_32421;CPB2_8369;COL6A3_33029;CDO1_8275;CDKN1A_8271;CAR3_8196;ASS1_33159;AQP9_32709;AHSG_8003;ABCC2_32541 34.006829000000025 26.8037 28.34965856976289 23.248486063829816 21.0456 20.11821488583834 58.78596340425534 40.808 49.2636221685882 0.348134;0.834827;108.064;104.197;39.7166;29.7555;13.3235;15.797;42.4094;12.4414;23.0963;18.7324;0.520151;80.7944;38.674;18.9476;16.4324;31.8111;57.1163;49.6814;89.1011;0.977494;64.9285;1.63089;26.4669;42.356;13.1992;1.28141E-12;59.5777;15.4757;28.5803;23.3972;0.750017;62.3934;87.5421;5.72128;56.2386;31.9826;25.8316;63.132;22.9638;6.24967;53.9626;26.8037;27.7316;12.402;46.2316 0.118102;0.27095;83.8836;80.3101;22.6911;23.3399;9.10952;13.013;26.2988;8.48981;17.4625;11.6701;0.160202;59.856;24.6273;11.6941;10.5224;24.7342;39.6402;33.4626;60.3265;0.322682;41.6103;0.663137;21.0456;26.3722;5.6804;1.28141E-12;31.0499;10.2138;22.529;18.3088;0.186019;39.0875;53.2453;0.985273;38.2681;24.4836;20.4374;42.651;18.5144;2.44025;28.5034;20.9825;21.9372;10.3013;31.1788 1.15962;2.99857;143.428;128.412;60.0334;40.808;24.6773;19.9134;81.7305;79.2355;32.9443;41.5978;2.88499;94.0621;71.0786;45.5481;39.929;44.3296;101.869;89.4404;106.138;5.49472;136.455;7.6286;35.4303;78.7583;32.7581;1.28142E-12;105.243;30.4106;38.8511;31.9156;4.70178;133.304;245.492;22.3625;102.888;45.5891;34.8042;121.149;30.0179;19.0606;77.0288;36.7081;37.4625;15.4235;81.7848 0 Exp 2,27(0.36);Exp 3,4(0.06);Exp 4,6(0.08);Hill,6(0.08);Linear,15(0.2);Poly 2,16(0.22);Power,2(0.03) 2.0103922815572783 167.08210825920105 1.5074360370635986 11.836054801940918 1.3913325141924704 1.776119887828827 32.55707991162086 45.97977083504584 22.167261274032143 31.115457792634572 53.40055845145194 82.13428501521484 DOWN 0.37333333333333335 0.6266666666666667 0.0 GO:0015718 8 monocarboxylic acid transport 51 54 17 17 14 16 13 13 149 41 2344 1.0 1.941E-5 1.941E-5 24.07 170698;65192;29500;298199;100359982;24360;25428;83842;29184;65054;312382;140668;25303 slco1a2;slc27a2;slc10a2;plin2;mpc2;fabp1;cyp7a1;crot;cd36;aqp9;abcg2;abcc3;abcc2 SLCO1A2_9886;SLC27A2_9860;SLC10A2_9833;PLIN2_9502;MPC2_33219;FABP1_33091;CYP7A1_8430;CROT_8384;CD36_8243;AQP9_32709;ABCG2_32656;ABCC3_7941;ABCC2_32541 34.84005461538461 33.8478 5.21654 27.531743085789977 30.671239337907494 22.426232302958923 25.79792946153846 26.4736 0.985273 21.126337246777123 22.772878686246173 17.019736085756062 53.006269230769234 46.9257 10.316 38.58004073287949 47.58069327633046 34.625559599356485 1.5 6.57209 4.5 26.691650000000003 104.197;7.62189;56.585;25.6517;46.8463;33.8478;5.72128;7.4229;48.1296;27.7316;5.21654;37.7175;46.2316 80.3101;5.49916;35.2796;20.9252;35.8494;26.4736;0.985273;5.75707;37.5433;21.9372;2.73368;30.9007;31.1788 128.412;13.3925;116.8;33.0375;69.127;46.9257;22.3625;10.316;69.1421;37.4625;11.386;48.9329;81.7848 8 5 8 65192;298199;100359982;24360;83842;29184;312382;140668 SLC27A2_9860;PLIN2_9502;MPC2_33219;FABP1_33091;CROT_8384;CD36_8243;ABCG2_32656;ABCC3_7941 26.556778750000003 29.74975 17.871095035487922 20.710263750000003 23.6994 14.281781766674367 37.782462499999994 39.9816 24.618235628721454 7.62189;25.6517;46.8463;33.8478;7.4229;48.1296;5.21654;37.7175 5.49916;20.9252;35.8494;26.4736;5.75707;37.5433;2.73368;30.9007 13.3925;33.0375;69.127;46.9257;10.316;69.1421;11.386;48.9329 5 170698;29500;25428;65054;25303 SLCO1A2_9886;SLC10A2_9833;CYP7A1_8430;AQP9_32709;ABCC2_32541 48.093296 46.2316 36.85507751735275 33.9381946 31.1788 29.110505624246645 77.36436 81.7848 46.89865290307386 104.197;56.585;5.72128;27.7316;46.2316 80.3101;35.2796;0.985273;21.9372;31.1788 128.412;116.8;22.3625;37.4625;81.7848 0 Exp 2,7(0.54);Exp 4,1(0.08);Hill,2(0.16);Linear,1(0.08);Poly 2,2(0.16) 2.2994947628437115 32.82594919204712 1.5074360370635986 5.963563919067383 1.3216200744439714 1.9223796129226685 19.873628589116535 49.8064806416527 14.313521713556984 37.28233720951995 32.033920189161755 73.9786182723767 UP 0.6153846153846154 0.38461538461538464 0.0 GO:0006706 6 steroid catabolic process 12 14 6 6 5 3 3 3 159 11 2374 0.99046 0.054735 0.054735 21.43 360268;289456;25428 sult1e1;hsd17b11;cyp7a1 SULT1E1_32446;HSD17B11_8832;CYP7A1_8430 26.113093333333335 22.4334 5.72128 22.458891638416475 30.42228458846007 18.093297229108508 18.536491 18.1233 0.985273 17.761418451313034 22.920576308674054 13.110809676758638 44.18866666666667 29.2247 22.3625 32.0454034180151 46.09789832632786 30.526119302473028 0.0 5.72128 0.5 14.07734 50.1846;22.4334;5.72128 36.5009;18.1233;0.985273 80.9788;29.2247;22.3625 2 1 2 360268;289456 SULT1E1_32446;HSD17B11_8832 36.309 36.309 19.623061706064135 27.3121 27.3121 12.994925581933902 55.10175 55.10175 36.5956750642067 50.1846;22.4334 36.5009;18.1233 80.9788;29.2247 1 25428 CYP7A1_8430 5.72128 5.72128 0.985273 0.985273 22.3625 22.3625 5.72128 0.985273 22.3625 0 Exp 2,1(0.34);Hill,1(0.34);Linear,1(0.34) 2.468404516850588 8.195726156234741 1.7401635646820068 4.560328960418701 1.5853555173837766 1.8952336311340332 0.6984649523781741 51.52772171428849 -1.5624460591481295 38.635428059148126 7.925878978891582 80.45145435444175 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0044281 3 small molecule metabolic process 449 498 114 114 79 100 68 68 94 430 1955 1.0 9.542E-12 1.136E-11 13.65 286954;24856;293688;360268;29573;65192;29500;246074;25106;501907;298490;83516;29441;24651;25513;294103;100359982;24552;24539;54404;50693;306251;25685;364070;29540;25675;24443;171155;113965;85255;81869;29328;24957;24384;114860;25256;246186;295143;65030;25315;171142;291075;29740;298541;25428;65210;24894;25146;83842;497840;81718;29184;54232;25698;25028;25284;65183;362732;50681;192272;170570;50559;24158;25287;170465;312382;25303;296925 ugt2b1;ttr;tm7sf2;sult1e1;slc37a4;slc27a2;slc10a2;scd;rgn;rgd1559459;ppcs;ppargc1a;por;pklr;pik3r1;papss2;mpc2;me1;lpl;itih4;itih3;itih1;igfbp1;iars2;hsd17b7;hmgcr;hdc;hadhb;hadh;hacl1;gstm7;gpx4;glul;gc;gale;fmo1;fgl1;etfdh;ephx2;ephx1;ehhadh;eci2;eci1;dhdds;cyp7a1;cyp2j4;cyp2a1;cyp17a1;crot;cps1;cdo1;cd36;car3;ass1;ampd1;amacr;aldh3a2;agmo;acox1;acot2;acot12;acot1;acadm;acadl;acaa2;abcg2;abcc2;aass UGT2B10_33303,UGT2B1_33224;TTR_10102;TM7SF2_10031;SULT1E1_32446;SLC37A4_9871;SLC27A2_9860;SLC10A2_9833;SCD1_9787;RGN_9699;RGD1559459_9690;PPCS_9540;PPARGC1A_33189;POR_9531;PKLR_9489;PIK3R1_32562;PAPSS2_33237;MPC2_33219;ME1_9215;LPL_32544;ITIH4_32725;ITIH3_32422;ITIH1_33132;IGFBP1_32306;IARS2_8858;HSD17B7_8834;HMGCR_8810;HDC_8788;HADHB_8777;HADH_8776;HACL1_8775;GSTM7_8761;GPX4_32827;GLUL_32832;GC_32893;GALE_8680;FMO1_32787;FGL1_8640;ETFDH_8575;EPHX2_33282;EPHX1_8567;EHHADH_8534;ECI2_8521;ECI1_8520;DHDDS_8467;CYP7A1_8430;CYP2J4_32580;CYP2A1_32717;CYP17A1_32365;CROT_8384;CPS1_32421;CDO1_8275;CD36_8243;CAR3_8196;ASS1_33159;AMPD1_32743;AMACR_8038;ALDH3A2_8024;AGMO_33265;ACOX1_7973;ACOT2_7969;ACOT12_32718;ACOT1_7968;ACADM_7957;ACADL_32776;ACAA2_7955;ABCG2_32656;ABCC2_32541;AASS_7936 35.17306211764706 31.66805 2.52378E-13 23.77638240126475 36.43947396038836 23.0917693368646 24.52011605882353 24.5155 2.52378E-13 15.300621740908223 25.179146656505782 14.39230900176598 58.942996764705896 44.58435 2.52379E-13 58.21930808171296 60.09412888878283 53.641438873824185 23.5 23.882550000000002 48.5 47.159875 47.47345;46.6406;82.3097;50.1846;39.7166;7.62189;56.585;105.46;77.4407;2.52378E-13;20.3353;42.4094;12.4414;23.0963;18.7324;34.4443;46.8463;80.7944;74.2041;57.1163;27.1247;98.1741;49.0259;24.7304;0.977494;1.63089;24.5745;31.8029;33.3125;17.6275;42.3152;45.9204;26.4669;42.356;71.148;65.2792;15.4757;18.1231;38.7293;12.4747;8.62809;10.6467;11.9473;47.9438;5.72128;17.8395;55.3937;49.6922;7.4229;31.9826;22.9638;48.1296;53.9626;26.8037;60.9045;2.03774;43.1079;31.5332;23.1906;8.54905;30.3423;31.2018;11.7137;33.4878;26.5872;5.21654;46.2316;27.4644 34.82915;28.5876;51.1696;36.5009;22.6911;5.49916;35.2796;63.7532;58.7732;2.52378E-13;16.7643;26.2988;8.48981;17.4625;11.6701;25.719;35.8494;59.856;49.8682;39.6402;21.5108;42.9071;32.6883;19.8021;0.322682;0.663137;21.0619;25.5756;25.7336;11.195;31.4035;34.2198;21.0456;26.3722;43.2839;39.7882;10.2138;14.869;29.2097;7.00435;7.31865;8.92359;7.15307;36.5688;0.985273;14.6501;38.7444;35.6654;5.75707;24.4836;18.5144;37.5433;28.5034;20.9825;50.0633;1.165;31.8774;24.5474;16.2815;7.19676;24.0157;26.858;8.36151;26.6039;21.3695;2.73368;31.1788;21.7498 76.47475;63.7146;209.842;80.9788;60.0334;13.3925;116.8;422.699;89.8047;2.52379E-13;25.6711;81.7305;79.2355;32.9443;41.5978;51.1014;69.127;94.0621;155.425;101.869;36.4819;104.278;89.1623;32.7087;5.49472;7.6286;29.28;42.1484;46.9856;37.6534;64.5991;70.4292;35.4303;78.7583;88.9033;82.9415;30.4106;23.0103;57.2113;23.684;10.3909;13.0581;19.001;71.3742;22.3625;22.6149;96.8569;81.6409;10.316;45.5891;30.0179;69.1421;77.0288;36.7081;82.6625;3.73641;66.3058;43.8459;33.4539;10.4125;41.1025;37.2719;18.9642;45.3228;35.0407;11.386;81.7848;37.0295 43 26 42 286954;24856;360268;65192;246074;25106;298490;100359982;24539;364070;24443;171155;113965;85255;81869;29328;25256;295143;65030;25315;171142;291075;29740;298541;65210;24894;25146;83842;29184;25028;25284;65183;362732;50681;192272;170570;50559;24158;25287;170465;312382;296925 UGT2B10_33303,UGT2B1_33224;TTR_10102;SULT1E1_32446;SLC27A2_9860;SCD1_9787;RGN_9699;PPCS_9540;MPC2_33219;LPL_32544;IARS2_8858;HDC_8788;HADHB_8777;HADH_8776;HACL1_8775;GSTM7_8761;GPX4_32827;FMO1_32787;ETFDH_8575;EPHX2_33282;EPHX1_8567;EHHADH_8534;ECI2_8521;ECI1_8520;DHDDS_8467;CYP2J4_32580;CYP2A1_32717;CYP17A1_32365;CROT_8384;CD36_8243;AMPD1_32743;AMACR_8038;ALDH3A2_8024;AGMO_33265;ACOX1_7973;ACOT2_7969;ACOT12_32718;ACOT1_7968;ACADM_7957;ACADL_32776;ACAA2_7955;ABCG2_32656;AASS_7936 33.906599047619046 31.3675 22.31716849737666 24.89132595238096 25.061500000000002 15.215340130660175 56.40163238095238 41.62545 65.68016915980314 47.47345;46.6406;50.1846;7.62189;105.46;77.4407;20.3353;46.8463;74.2041;24.7304;24.5745;31.8029;33.3125;17.6275;42.3152;45.9204;65.2792;18.1231;38.7293;12.4747;8.62809;10.6467;11.9473;47.9438;17.8395;55.3937;49.6922;7.4229;48.1296;60.9045;2.03774;43.1079;31.5332;23.1906;8.54905;30.3423;31.2018;11.7137;33.4878;26.5872;5.21654;27.4644 34.82915;28.5876;36.5009;5.49916;63.7532;58.7732;16.7643;35.8494;49.8682;19.8021;21.0619;25.5756;25.7336;11.195;31.4035;34.2198;39.7882;14.869;29.2097;7.00435;7.31865;8.92359;7.15307;36.5688;14.6501;38.7444;35.6654;5.75707;37.5433;50.0633;1.165;31.8774;24.5474;16.2815;7.19676;24.0157;26.858;8.36151;26.6039;21.3695;2.73368;21.7498 76.47475;63.7146;80.9788;13.3925;422.699;89.8047;25.6711;69.127;155.425;32.7087;29.28;42.1484;46.9856;37.6534;64.5991;70.4292;82.9415;23.0103;57.2113;23.684;10.3909;13.0581;19.001;71.3742;22.6149;96.8569;81.6409;10.316;69.1421;82.6625;3.73641;66.3058;43.8459;33.4539;10.4125;41.1025;37.2719;18.9642;45.3228;35.0407;11.386;37.0295 26 293688;29573;29500;501907;83516;29441;24651;25513;294103;24552;54404;50693;306251;25685;29540;25675;24957;24384;114860;246186;25428;497840;81718;54232;25698;25303 TM7SF2_10031;SLC37A4_9871;SLC10A2_9833;RGD1559459_9690;PPARGC1A_33189;POR_9531;PKLR_9489;PIK3R1_32562;PAPSS2_33237;ME1_9215;ITIH4_32725;ITIH3_32422;ITIH1_33132;IGFBP1_32306;HSD17B7_8834;HMGCR_8810;GLUL_32832;GC_32893;GALE_8680;FGL1_8640;CYP7A1_8430;CPS1_32421;CDO1_8275;CAR3_8196;ASS1_33159;ABCC2_32541 37.21888707692308 33.21345 26.290465440662693 23.920469307692315 23.58735 15.72055811388136 63.04827769230771 55.5674 44.50481789117372 82.3097;39.7166;56.585;2.52378E-13;42.4094;12.4414;23.0963;18.7324;34.4443;80.7944;57.1163;27.1247;98.1741;49.0259;0.977494;1.63089;26.4669;42.356;71.148;15.4757;5.72128;31.9826;22.9638;53.9626;26.8037;46.2316 51.1696;22.6911;35.2796;2.52378E-13;26.2988;8.48981;17.4625;11.6701;25.719;59.856;39.6402;21.5108;42.9071;32.6883;0.322682;0.663137;21.0456;26.3722;43.2839;10.2138;0.985273;24.4836;18.5144;28.5034;20.9825;31.1788 209.842;60.0334;116.8;2.52379E-13;81.7305;79.2355;32.9443;41.5978;51.1014;94.0621;101.869;36.4819;104.278;89.1623;5.49472;7.6286;35.4303;78.7583;88.9033;30.4106;22.3625;45.5891;30.0179;77.0288;36.7081;81.7848 0 Exp 2,26(0.38);Exp 3,2(0.03);Exp 4,4(0.06);Hill,5(0.08);Linear,18(0.27);Poly 2,13(0.19);Power,1(0.02) 2.5072619460342938 559.427192568779 1.5074360370635986 344.14306640625 41.29254669527885 1.8872262239456177 29.52177474618933 40.82434948910481 20.883389118595364 28.1568429990517 45.105145615420426 72.78084791399135 UP 0.6176470588235294 0.38235294117647056 0.0 GO:0048660 6 regulation of smooth muscle cell proliferation 79 82 9 9 9 7 7 7 155 75 2310 0.85335 0.26374 0.36001 8.54 83516;25513;24516;25675;24890;24330;114851 ppargc1a;pik3r1;jun;hmgcr;esr1;egr1;cdkn1a PPARGC1A_33189;PIK3R1_32562;JUN_8938;HMGCR_8810;ESR1_33192;EGR1_8533;CDKN1A_8271 15.657425285714286 16.4324 0.750017 14.680535256347733 14.967684536239013 15.764316846667011 10.012786571428572 10.5224 0.186019 9.818257516711471 9.045726386429227 10.329256565952564 32.36626857142857 31.9156 4.70178 26.248058710037608 32.566183164764524 28.382769063838342 3.5 17.5824 42.4094;18.7324;16.4324;1.63089;23.3972;0.750017;6.24967 26.2988;11.6701;10.5224;0.663137;18.3088;0.186019;2.44025 81.7305;41.5978;39.929;7.6286;31.9156;4.70178;19.0606 0 7 0 7 83516;25513;24516;25675;24890;24330;114851 PPARGC1A_33189;PIK3R1_32562;JUN_8938;HMGCR_8810;ESR1_33192;EGR1_8533;CDKN1A_8271 15.657425285714286 16.4324 14.680535256347733 10.012786571428572 10.5224 9.818257516711471 32.36626857142857 31.9156 26.248058710037608 42.4094;18.7324;16.4324;1.63089;23.3972;0.750017;6.24967 26.2988;11.6701;10.5224;0.663137;18.3088;0.186019;2.44025 81.7305;41.5978;39.929;7.6286;31.9156;4.70178;19.0606 0 Exp 2,2(0.29);Exp 4,2(0.29);Hill,1(0.15);Poly 2,2(0.29) 2.0882662200163096 15.488855123519897 1.522104263305664 4.21828556060791 0.9308481647592037 1.9017701148986816 4.781932573262937 26.532917998165637 2.739319616210013 17.28625352664713 12.921434562833522 51.81110258002363 DOWN 0.0 1.0 0.0 GO:0060992 5 response to fungicide 17 19 5 5 5 3 3 3 159 16 2369 0.97118 0.11579 0.11579 15.79 58954;361969;25146 klf6;fga;cyp17a1 KLF6_8969;FGA_8632;CYP17A1_32365 32.4067 28.5803 18.9476 15.72541287248128 30.233503916601716 12.150129229265588 23.296166666666664 22.529 11.6941 12.004049918395602 22.474725331254866 9.277674186131904 55.3467 45.5481 38.8511 23.016323934981447 48.067243322941025 19.57101160887555 0.0 18.9476 0.5 23.76395 18.9476;28.5803;49.6922 11.6941;22.529;35.6654 45.5481;38.8511;81.6409 1 2 1 25146 CYP17A1_32365 49.6922 49.6922 35.6654 35.6654 81.6409 81.6409 49.6922 35.6654 81.6409 2 58954;361969 KLF6_8969;FGA_8632 23.76395 23.76395 6.811347491135656 17.11155 17.11155 7.661431263478115 42.199600000000004 42.199600000000004 4.735494113606276 18.9476;28.5803 11.6941;22.529 45.5481;38.8511 0 Linear,2(0.67);Poly 2,1(0.34) 1.6672085931163652 5.025344371795654 1.541895866394043 1.90940523147583 0.20353715132035508 1.5740432739257812 14.611720144111658 50.201679855888344 9.71230542123392 36.880027912099415 29.301277593550356 81.39212240644966 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0051409 4 response to nitrosative stress 5 5 1 1 1 1 1 1 161 4 2381 0.9646 0.28025 0.28025 20.0 116663 dusp6 DUSP6_8506 62.3934 62.3934 62.3934 62.3934 39.0875 39.0875 39.0875 39.0875 133.304 133.304 133.304 133.304 0.0 62.3934 0.0 62.3934 62.3934 39.0875 133.304 0 1 0 1 116663 DUSP6_8506 62.3934 62.3934 39.0875 39.0875 133.304 133.304 62.3934 39.0875 133.304 0 Exp 2,1(1) 1.6357084512710571 1.6357084512710571 1.6357084512710571 1.6357084512710571 0.0 1.6357084512710571 62.3934 62.3934 39.0875 39.0875 133.304 133.304 DOWN 0.0 1.0 0.0 GO:0070373 9 negative regulation of ERK1 and ERK2 cascade 25 27 2 2 2 2 2 2 160 25 2360 0.75576 0.5205 0.6885 7.41 293615;116663 sirt3;dusp6 SIRT3_9828;DUSP6_8506 32.38679 32.38679 2.38018 42.43575482284014 31.148363723631917 42.39959773512246 19.824794999999998 19.824794999999998 0.56209 27.24157865899203 19.02978883216142 27.218367662669394 71.066585 71.066585 8.82917 88.0169963800427 68.49793595536534 87.94200211466331 0.5 32.38679 2.38018;62.3934 0.56209;39.0875 8.82917;133.304 1 1 1 293615 SIRT3_9828 2.38018 2.38018 0.56209 0.56209 8.82917 8.82917 2.38018 0.56209 8.82917 1 116663 DUSP6_8506 62.3934 62.3934 39.0875 39.0875 133.304 133.304 62.3934 39.0875 133.304 0 Exp 2,1(0.5);Hill,1(0.5) 1.5772974248912799 3.156680703163147 1.5209722518920898 1.6357084512710571 0.08113074462843951 1.5783403515815735 -26.426165600000004 91.1997456 -17.930106799999997 57.5796968 -50.918748399999984 193.05191839999998 CONFLICT 0.5 0.5 0.0 GO:1901361 5 organic cyclic compound catabolic process 75 89 13 13 11 9 8 8 154 81 2304 0.89112 0.20171 0.27069 8.99 79426;286954;360268;289456;24443;308441;65030;25428 zfp36;ugt2b1;sult1e1;hsd17b11;hdc;exosc5;ephx2;cyp7a1 ZFP36_10204;UGT2B10_33303,UGT2B1_33224;SULT1E1_32446;HSD17B11_8832;HDC_8788;EXOSC5_32543;EPHX2_33282;CYP7A1_8430 28.9246955 31.6519 0.348134 18.81284881119852 34.39368393066093 16.383979430722224 21.570240625 25.135800000000003 0.118102 14.424450641117424 25.75713762099495 11.924618204401328 44.85362125 43.24565 1.15962 28.430816371775403 52.74946582128321 27.095060342452594 3.5 31.6519 0.348134;47.47345;50.1846;22.4334;24.5745;41.9329;38.7293;5.72128 0.118102;34.82915;36.5009;18.1233;21.0619;31.7336;29.2097;0.985273 1.15962;76.47475;80.9788;29.2247;29.28;62.1373;57.2113;22.3625 7 2 6 286954;360268;289456;24443;308441;65030 UGT2B10_33303,UGT2B1_33224;SULT1E1_32446;HSD17B11_8832;HDC_8788;EXOSC5_32543;EPHX2_33282 37.55469166666666 40.3311 11.623971797127545 28.576425 30.47165 7.456521620685486 55.88447500000001 59.6743 22.419119295452894 47.47345;50.1846;22.4334;24.5745;41.9329;38.7293 34.82915;36.5009;18.1233;21.0619;31.7336;29.2097 76.47475;80.9788;29.2247;29.28;62.1373;57.2113 2 79426;25428 ZFP36_10204;CYP7A1_8430 3.034707 3.034707 3.799387972905374 0.5516875 0.5516875 0.6131824945483195 11.76106 11.76106 14.992700228684626 0.348134;5.72128 0.118102;0.985273 1.15962;22.3625 0 Exp 2,5(0.56);Hill,2(0.23);Linear,2(0.23) 2.812946072001263 37.302910804748535 1.5979743003845215 17.513065338134766 5.162595060512782 1.8952336311340332 15.888056391520967 41.96133460847903 11.57460629903972 31.56587495096027 25.15207065987114 64.55517184012886 UP 0.75 0.25 0.0 GO:0016525 7 negative regulation of angiogenesis 32 34 3 3 3 3 3 3 159 31 2354 0.83336 0.36878 0.47423 8.82 24794;25112;29184 serpina3c;gadd45a;cd36 SERPINA3C_32925;GADD45A_8678;CD36_8243 60.27153333333333 48.1296 29.766 38.05798550965794 69.09380316293466 36.685186354043346 50.130500000000005 37.5433 23.347 34.82704046125653 57.87467202205349 34.08447550195721 75.1349 69.1421 40.8256 37.664976986187064 85.06389882478116 34.19209568486702 0.5 38.9478 29.766;102.919;48.1296 23.347;89.5012;37.5433 40.8256;115.437;69.1421 1 2 1 29184 CD36_8243 48.1296 48.1296 37.5433 37.5433 69.1421 69.1421 48.1296 37.5433 69.1421 2 24794;25112 SERPINA3C_32925;GADD45A_8678 66.3425 66.3425 51.726982364139495 56.424099999999996 56.424099999999996 46.77808342397111 78.1313 78.1313 52.75822689382198 29.766;102.919 23.347;89.5012 40.8256;115.437 0 Exp 2,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 1.9192206608202453 5.924481511116028 1.6202073097229004 2.6703107357025146 0.6023457065426594 1.6339634656906128 17.204868502854204 103.33819816381248 10.719993676646482 89.54100632335353 32.51296618008754 117.75683381991246 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0031324 6 negative regulation of cellular metabolic process 513 545 54 54 47 49 43 43 119 502 1883 0.95726 0.062884 0.11264 7.89 79426;24522;246273;293615;79224;24794;24648;25106;252922;83516;29441;25513;25591;299282;288001;24516;54404;50693;306251;63868;24471;24464;25675;299626;25112;294515;83928;24360;24890;116636;24330;116663;140942;25428;113936;25695;114851;29184;246142;79431;25377;25373;25287 zfp36;zfp354a;trib3;sirt3;serpind1;serpina3c;serpina1;rgn;pzp;ppargc1a;por;pik3r1;parp1;loc299282;kng1;jun;itih4;itih3;itih1;hspd1;hspb1;hp;hmgcr;gadd45b;gadd45a;foxo3;fetub;fabp1;esr1;eif4ebp1;egr1;dusp6;ddit4;cyp7a1;cpb2;cebpd;cdkn1a;cd36;bmf;bhlhe40;ambp;ahsg;acadl ZFP36_10204;ZFP354A_10203;TRIB3_10079;SIRT3_9828;SERPIND1_9812;SERPINA3C_32925;SERPINA1_9807;RGN_9699;PZP_9633;PPARGC1A_33189;POR_9531;PIK3R1_32562;PARP1_9425;LOC299282_9119;KNG1L1_34113;JUN_8938;ITIH4_32725;ITIH3_32422;ITIH1_33132;HSPD1_8849;HSPB1_8847;HP_8823;HMGCR_8810;GADD45B_8679;GADD45A_8678;FOXO3_8662;FETUB_33027;FABP1_33091;ESR1_33192;EIF4EBP1_8550;EGR1_8533;DUSP6_8506;DDIT4_8450;CYP7A1_8430;CPB2_8369;CEBPD_8283;CDKN1A_8271;CD36_8243;BMF_8152;BHLHE40_8141;AMBP_33085;AHSG_8003;ACADL_32776 39.833698465116285 29.766 0.306936 33.26365216069735 44.72734547864437 34.545550271243535 26.96439221395349 22.307 0.0732342 22.80066213242446 30.512202493227115 24.855733324981962 62.90953093023254 45.3228 1.15962 50.659109489164734 67.99027815849566 46.53558888889226 26.5 42.33365 0.348134;0.834827;108.064;2.38018;28.261;29.766;15.797;77.4407;34.1871;42.4094;12.4414;18.7324;26.9741;45.2017;24.3655;16.4324;57.1163;27.1247;98.1741;42.2579;89.1011;64.9285;1.63089;106.367;102.919;13.1992;32.5155;33.8478;23.3972;83.9001;0.750017;62.3934;87.5421;5.72128;25.8316;0.306936;6.24967;48.1296;94.8767;57.8085;17.2343;12.402;33.4878 0.118102;0.27095;83.8836;0.56209;22.307;23.347;13.013;58.7732;26.3085;26.2988;8.48981;11.6701;21.799;30.7472;19.538;10.5224;39.6402;21.5108;42.9071;23.9469;60.3265;41.6103;0.663137;52.7132;89.5012;5.6804;19.6094;26.4736;18.3088;42.4185;0.186019;39.0875;53.2453;0.985273;20.4374;0.0732342;2.44025;37.5433;73.1342;38.3491;14.1233;10.3013;26.6039 1.15962;2.99857;143.428;8.82917;38.3264;40.8256;19.9134;89.8047;48.5666;81.7305;79.2355;41.5978;35.2797;78.6415;32.1467;39.929;101.869;36.4819;104.278;102.383;106.138;136.455;7.6286;109.434;115.437;32.7581;49.9875;46.9257;31.9156;107.32;4.70178;133.304;245.492;22.3625;34.8042;1.73689;19.0606;69.1421;109.848;110.58;21.9073;15.4235;45.3228 10 33 10 293615;25106;25591;63868;299626;24360;116636;29184;246142;25287 SIRT3_9828;RGN_9699;PARP1_9425;HSPD1_8849;GADD45B_8679;FABP1_33091;EIF4EBP1_8550;CD36_8243;BMF_8152;ACADL_32776 54.966188 45.19375 33.73353031195612 36.396789 32.0736 21.083782820249134 72.42891699999998 79.4734 36.5255884443891 2.38018;77.4407;26.9741;42.2579;106.367;33.8478;83.9001;48.1296;94.8767;33.4878 0.56209;58.7732;21.799;23.9469;52.7132;26.4736;42.4185;37.5433;73.1342;26.6039 8.82917;89.8047;35.2797;102.383;109.434;46.9257;107.32;69.1421;109.848;45.3228 33 79426;24522;246273;79224;24794;24648;252922;83516;29441;25513;299282;288001;24516;54404;50693;306251;24471;24464;25675;25112;294515;83928;24890;24330;116663;140942;25428;113936;25695;114851;79431;25377;25373 ZFP36_10204;ZFP354A_10203;TRIB3_10079;SERPIND1_9812;SERPINA3C_32925;SERPINA1_9807;PZP_9633;PPARGC1A_33189;POR_9531;PIK3R1_32562;LOC299282_9119;KNG1L1_34113;JUN_8938;ITIH4_32725;ITIH3_32422;ITIH1_33132;HSPB1_8847;HP_8823;HMGCR_8810;GADD45A_8678;FOXO3_8662;FETUB_33027;ESR1_33192;EGR1_8533;DUSP6_8506;DDIT4_8450;CYP7A1_8430;CPB2_8369;CEBPD_8283;CDKN1A_8271;BHLHE40_8141;AMBP_33085;AHSG_8003 35.24809557575758 25.8316 32.23273056736362 24.10609015757576 19.6094 22.827140897497554 60.024868484848476 39.929 54.37101966769586 0.348134;0.834827;108.064;28.261;29.766;15.797;34.1871;42.4094;12.4414;18.7324;45.2017;24.3655;16.4324;57.1163;27.1247;98.1741;89.1011;64.9285;1.63089;102.919;13.1992;32.5155;23.3972;0.750017;62.3934;87.5421;5.72128;25.8316;0.306936;6.24967;57.8085;17.2343;12.402 0.118102;0.27095;83.8836;22.307;23.347;13.013;26.3085;26.2988;8.48981;11.6701;30.7472;19.538;10.5224;39.6402;21.5108;42.9071;60.3265;41.6103;0.663137;89.5012;5.6804;19.6094;18.3088;0.186019;39.0875;53.2453;0.985273;20.4374;0.0732342;2.44025;38.3491;14.1233;10.3013 1.15962;2.99857;143.428;38.3264;40.8256;19.9134;48.5666;81.7305;79.2355;41.5978;78.6415;32.1467;39.929;101.869;36.4819;104.278;106.138;136.455;7.6286;115.437;32.7581;49.9875;31.9156;4.70178;133.304;245.492;22.3625;34.8042;1.73689;19.0606;110.58;21.9073;15.4235 0 Exp 2,14(0.33);Exp 3,3(0.07);Exp 4,3(0.07);Hill,6(0.14);Linear,7(0.17);Poly 2,9(0.21);Power,1(0.03) 1.9500636659880886 88.05723249912262 1.5197933912277222 4.591650485992432 0.7743755738307628 1.7037216424942017 29.89128604396337 49.77611088626919 20.149338193403775 33.77944623450321 47.767665058248376 78.05139680221677 DOWN 0.23255813953488372 0.7674418604651163 0.0 GO:0033993 5 response to lipid 414 443 59 59 46 53 41 41 121 402 1983 0.99689 0.0055449 0.0097241 9.26 79426;286954;170698;24648;246074;83516;25513;25591;24314;81525;25493;24539;24516;63868;24471;29540;24464;25675;29328;24384;294515;314322;25661;25256;361969;24890;25315;116636;24330;140942;25428;25146;497840;81718;114851;29184;25698;24158;312382;140668;25303 zfp36;ugt2b1;slco1a2;serpina1;scd;ppargc1a;pik3r1;parp1;nqo1;nfkbib;nfkbia;lpl;jun;hspd1;hspb1;hsd17b7;hp;hmgcr;gpx4;gc;foxo3;fos;fn1;fmo1;fga;esr1;ephx1;eif4ebp1;egr1;ddit4;cyp7a1;cyp17a1;cps1;cdo1;cdkn1a;cd36;ass1;acadm;abcg2;abcc3;abcc2 ZFP36_10204;UGT2B10_33303,UGT2B1_33224;SLCO1A2_9886;SERPINA1_9807;SCD1_9787;PPARGC1A_33189;PIK3R1_32562;PARP1_9425;NQO1_33055;NFKBIB_9308;NFKBIA_9307;LPL_32544;JUN_8938;HSPD1_8849;HSPB1_8847;HSD17B7_8834;HP_8823;HMGCR_8810;GPX4_32827;GC_32893;FOXO3_8662;FOS_8657;FN1_8655;FMO1_32787;FGA_8632;ESR1_33192;EPHX1_8567;EIF4EBP1_8550;EGR1_8533;DDIT4_8450;CYP7A1_8430;CYP17A1_32365;CPS1_32421;CDO1_8275;CDKN1A_8271;CD36_8243;ASS1_33159;ACADM_7957;ABCG2_32656;ABCC3_7941;ABCC2_32541 37.18723965853662 30.5572 1.28141E-12 30.779056500207904 38.955220657487665 27.14013228031354 24.847481829268325 23.9469 1.28141E-12 20.462330229125534 25.851402307646616 17.29695226264526 70.47967951219515 41.5978 1.28142E-12 78.3375341671 69.86103272222634 67.01164017843064 21.5 34.85005 0.348134;47.47345;104.197;15.797;105.46;42.4094;18.7324;26.9741;87.2765;30.5572;0.520151;74.2041;16.4324;42.2579;89.1011;0.977494;64.9285;1.63089;45.9204;42.356;13.1992;1.28141E-12;59.5777;65.2792;28.5803;23.3972;12.4747;83.9001;0.750017;87.5421;5.72128;49.6922;31.9826;22.9638;6.24967;48.1296;26.8037;11.7137;5.21654;37.7175;46.2316 0.118102;34.82915;80.3101;13.013;63.7532;26.2988;11.6701;21.799;60.6992;24.2439;0.160202;49.8682;10.5224;23.9469;60.3265;0.322682;41.6103;0.663137;34.2198;26.3722;5.6804;1.28141E-12;31.0499;39.7882;22.529;18.3088;7.00435;42.4185;0.186019;53.2453;0.985273;35.6654;24.4836;18.5144;2.44025;37.5433;20.9825;8.36151;2.73368;30.9007;31.1788 1.15962;76.47475;128.412;19.9134;422.699;81.7305;41.5978;35.2797;197.117;41.2611;2.88499;155.425;39.929;102.383;106.138;5.49472;136.455;7.6286;70.4292;78.7583;32.7581;1.28142E-12;105.243;82.9415;38.8511;31.9156;23.684;107.32;4.70178;245.492;22.3625;81.6409;45.5891;30.0179;19.0606;69.1421;36.7081;18.9642;11.386;48.9329;81.7848 17 25 16 286954;246074;25591;24314;81525;24539;63868;29328;25256;25315;116636;25146;29184;24158;312382;140668 UGT2B10_33303,UGT2B1_33224;SCD1_9787;PARP1_9425;NQO1_33055;NFKBIB_9308;LPL_32544;HSPD1_8849;GPX4_32827;FMO1_32787;EPHX1_8567;EIF4EBP1_8550;CYP17A1_32365;CD36_8243;ACADM_7957;ABCG2_32656;ABCC3_7941 48.390449375 46.696925 28.77219627464808 32.360936875 34.524474999999995 17.59877017224735 96.567521875 73.451975 100.0024546751278 47.47345;105.46;26.9741;87.2765;30.5572;74.2041;42.2579;45.9204;65.2792;12.4747;83.9001;49.6922;48.1296;11.7137;5.21654;37.7175 34.82915;63.7532;21.799;60.6992;24.2439;49.8682;23.9469;34.2198;39.7882;7.00435;42.4185;35.6654;37.5433;8.36151;2.73368;30.9007 76.47475;422.699;35.2797;197.117;41.2611;155.425;102.383;70.4292;82.9415;23.684;107.32;81.6409;69.1421;18.9642;11.386;48.9329 25 79426;170698;24648;83516;25513;25493;24516;24471;29540;24464;25675;24384;294515;314322;25661;361969;24890;24330;140942;25428;497840;81718;114851;25698;25303 ZFP36_10204;SLCO1A2_9886;SERPINA1_9807;PPARGC1A_33189;PIK3R1_32562;NFKBIA_9307;JUN_8938;HSPB1_8847;HSD17B7_8834;HP_8823;HMGCR_8810;GC_32893;FOXO3_8662;FOS_8657;FN1_8655;FGA_8632;ESR1_33192;EGR1_8533;DDIT4_8450;CYP7A1_8430;CPS1_32421;CDO1_8275;CDKN1A_8271;ASS1_33159;ABCC2_32541 30.01718544000005 22.9638 30.40215940800965 20.03887060000005 18.3088 21.036899135956556 53.78346040000006 36.7081 56.86427724455397 0.348134;104.197;15.797;42.4094;18.7324;0.520151;16.4324;89.1011;0.977494;64.9285;1.63089;42.356;13.1992;1.28141E-12;59.5777;28.5803;23.3972;0.750017;87.5421;5.72128;31.9826;22.9638;6.24967;26.8037;46.2316 0.118102;80.3101;13.013;26.2988;11.6701;0.160202;10.5224;60.3265;0.322682;41.6103;0.663137;26.3722;5.6804;1.28141E-12;31.0499;22.529;18.3088;0.186019;53.2453;0.985273;24.4836;18.5144;2.44025;20.9825;31.1788 1.15962;128.412;19.9134;81.7305;41.5978;2.88499;39.929;106.138;5.49472;136.455;7.6286;78.7583;32.7581;1.28142E-12;105.243;38.8511;31.9156;4.70178;245.492;22.3625;45.5891;30.0179;19.0606;36.7081;81.7848 0 Exp 2,17(0.41);Exp 3,3(0.08);Exp 4,6(0.15);Hill,5(0.12);Linear,4(0.1);Poly 2,6(0.15);Power,1(0.03) 1.9083779744153002 83.00834906101227 1.5074360370635986 4.560328960418701 0.6365963699571014 1.7939516305923462 27.765752818138544 46.60872649893468 18.58395081504495 31.111012843491707 46.50051539260684 94.45884363178345 DOWN 0.3902439024390244 0.6097560975609756 0.0 GO:0044419 2 interspecies interaction between organisms 272 296 31 31 25 25 20 20 142 276 2109 0.67251 0.42154 0.79965 6.76 312688;25357;24825;29500;246074;85253;24651;25513;24539;24516;63868;24471;24464;25661;361969;308441;140942;29184;54232;313421 usp18;thrsp;tf;slc10a2;scd;plg;pklr;pik3r1;lpl;jun;hspd1;hspb1;hp;fn1;fga;exosc5;ddit4;cd36;car3;c8b USP18_10138;THRSP_33314;TF_10003;SLC10A2_9833;SCD1_9787;PLG_9501;PKLR_9489;PIK3R1_32562;LPL_32544;JUN_8938;HSPD1_8849;HSPB1_8847;HP_8823;FN1_8655;FGA_8632;EXOSC5_32543;DDIT4_8450;CD36_8243;CAR3_8196;C8B_8181 54.44563000000001 51.0461 16.4324 28.14759133389756 55.13802793780834 24.59115079680059 35.40792999999999 31.391750000000002 10.5224 17.656602645651326 35.66737448731502 15.672563752840315 108.85227 89.7059 27.9161 91.82291545540599 104.30430673449614 76.83001703845432 13.5 67.8571 108.883;32.2053;45.1539;56.585;105.46;70.7857;23.0963;18.7324;74.2041;16.4324;42.2579;89.1011;64.9285;59.5777;28.5803;41.9329;87.5421;48.1296;53.9626;21.3618 73.1414;24.3966;28.132;35.2796;63.7532;46.2356;17.4625;11.6701;49.8682;10.5224;23.9469;60.3265;41.6103;31.0499;22.529;31.7336;53.2453;37.5433;28.5034;17.2088 138.144;46.6068;61.5341;116.8;422.699;150.579;32.9443;41.5978;155.425;39.929;102.383;106.138;136.455;105.243;38.8511;62.1373;245.492;69.1421;77.0288;27.9161 7 13 7 312688;24825;246074;24539;63868;308441;29184 USP18_10138;TF_10003;SCD1_9787;LPL_32544;HSPD1_8849;EXOSC5_32543;CD36_8243 66.57448571428571 48.1296 29.88272635137946 44.01694285714286 37.5433 18.796797836675722 144.49492857142857 102.383 128.24069003081297 108.883;45.1539;105.46;74.2041;42.2579;41.9329;48.1296 73.1414;28.132;63.7532;49.8682;23.9469;31.7336;37.5433 138.144;61.5341;422.699;155.425;102.383;62.1373;69.1421 13 25357;29500;85253;24651;25513;24516;24471;24464;25661;361969;140942;54232;313421 THRSP_33314;SLC10A2_9833;PLG_9501;PKLR_9489;PIK3R1_32562;JUN_8938;HSPB1_8847;HP_8823;FN1_8655;FGA_8632;DDIT4_8450;CAR3_8196;C8B_8181 47.914707692307694 53.9626 25.998933901106458 30.772307692307688 28.5034 15.825286801796128 89.66006923076922 77.0288 63.14153386728877 32.2053;56.585;70.7857;23.0963;18.7324;16.4324;89.1011;64.9285;59.5777;28.5803;87.5421;53.9626;21.3618 24.3966;35.2796;46.2356;17.4625;11.6701;10.5224;60.3265;41.6103;31.0499;22.529;53.2453;28.5034;17.2088 46.6068;116.8;150.579;32.9443;41.5978;39.929;106.138;136.455;105.243;38.8511;245.492;77.0288;27.9161 0 Exp 2,9(0.45);Exp 3,1(0.05);Linear,3(0.15);Poly 2,5(0.25);Power,2(0.1) 1.9247529704788888 39.915942788124084 1.5122476816177368 3.910295248031616 0.6163177756789476 1.701328158378601 42.10940418540613 66.78185581459385 27.669582701593725 43.14627729840629 68.60910295330126 149.09543704669875 DOWN 0.35 0.65 0.0 GO:0006914 4 autophagy 36 40 2 2 2 2 2 2 160 38 2347 0.527 0.73412 1.0 5.0 83516;155423 ppargc1a;anxa7 PPARGC1A_33189;ANXA7_8051 73.5247 73.5247 42.4094 44.00367925730758 72.24229067245119 43.966289823150106 35.1121 35.1121 26.2988 12.463888389262829 34.748862039045555 12.453297962686145 95.20975 95.20975 81.7305 19.062538160617553 94.65420607375272 19.046340935124956 1.0 104.64 42.4094;104.64 26.2988;43.9254 81.7305;108.689 1 1 1 155423 ANXA7_8051 104.64 104.64 43.9254 43.9254 108.689 108.689 104.64 43.9254 108.689 1 83516 PPARGC1A_33189 42.4094 42.4094 26.2988 26.2988 81.7305 81.7305 42.4094 26.2988 81.7305 0 Exp 2,1(0.5);Exp 3,1(0.5) 1.648513399248466 3.303800106048584 1.5461770296096802 1.7576230764389038 0.1495149335680323 1.651900053024292 12.538711999999997 134.510688 17.838032 52.386168 68.79042000000001 121.62907999999999 CONFLICT 0.5 0.5 0.0 GO:0000041 8 transition metal ion transport 18 19 4 4 4 3 3 3 159 16 2369 0.97118 0.11579 0.11579 15.79 24825;304929;25303 tf;f5;abcc2 TF_10003;F5_33079;ABCC2_32541 33.998133333333335 45.1539 10.6089 20.262836333132967 40.3990362224687 15.155237114477579 20.63403 28.132 2.59129 15.699557241868318 25.288909566629695 11.655090907843284 60.27556666666667 61.5341 37.5078 22.165313258858603 64.05484583267311 17.365334642374325 0.0 10.6089 0.5 27.8814 45.1539;10.6089;46.2316 28.132;2.59129;31.1788 61.5341;37.5078;81.7848 1 2 1 24825 TF_10003 45.1539 45.1539 28.132 28.132 61.5341 61.5341 45.1539 28.132 61.5341 2 304929;25303 F5_33079;ABCC2_32541 28.42025 28.42025 25.189052734174023 16.885044999999998 16.885044999999998 20.21442217823824 59.646300000000004 59.646300000000004 31.30856695059677 10.6089;46.2316 2.59129;31.1788 37.5078;81.7848 0 Exp 2,1(0.34);Hill,1(0.34);Poly 2,1(0.34) 1.7979189889410916 5.3976664543151855 1.7042291164398193 1.8589661121368408 0.08317305686697518 1.8344712257385254 11.068575470833231 56.92769119583344 2.868308544488798 38.3997514555112 35.19315349638484 85.3579798369485 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0008283 3 cell population proliferation 139 149 15 15 11 13 9 9 153 140 2245 0.52112 0.61683 1.0 6.04 63868;290556;24957;499914;246186;80841;24890;24330;155423 hspd1;gnl3;glul;gins1;fgl1;fabp7;esr1;egr1;anxa7 HSPD1_8849;GNL3_8735;GLUL_32832;GINS1_8707;FGL1_8640;FABP7_8592;ESR1_33192;EGR1_8533;ANXA7_8051 42.68232411111111 26.4669 0.750017 34.611409346949564 38.82682620430394 33.27362787741737 25.688613222222223 21.0456 0.186019 18.080218196381047 23.576795188308378 17.632593831188093 75.5495311111111 35.6155 4.70178 71.54773698137637 63.06166905513035 50.50725759744265 6.5 73.2761 42.2579;87.6357;26.4669;58.9165;15.4757;24.601;23.3972;0.750017;104.64 23.9469;54.41;21.0456;44.7208;10.2138;14.4402;18.3088;0.186019;43.9254 102.383;238.963;35.4303;91.837;30.4106;35.6155;31.9156;4.70178;108.689 5 4 5 63868;290556;499914;80841;155423 HSPD1_8849;GNL3_8735;GINS1_8707;FABP7_8592;ANXA7_8051 63.610220000000005 58.9165 32.635633737940495 36.28866 43.9254 16.48846559319574 115.49749999999999 102.383 74.8382065809303 42.2579;87.6357;58.9165;24.601;104.64 23.9469;54.41;44.7208;14.4402;43.9254 102.383;238.963;91.837;35.6155;108.689 4 24957;246186;24890;24330 GLUL_32832;FGL1_8640;ESR1_33192;EGR1_8533 16.52245425 19.43645 11.489409640576504 12.438554750000002 14.261300000000002 9.373991914393972 25.61457 31.1631 14.099624390254748 26.4669;15.4757;23.3972;0.750017 21.0456;10.2138;18.3088;0.186019 35.4303;30.4106;31.9156;4.70178 0 Exp 2,3(0.34);Exp 3,2(0.23);Hill,2(0.23);Linear,1(0.12);Poly 2,1(0.12) 2.040885095327131 19.41387963294983 1.511321783065796 4.21828556060791 0.8581516459546769 1.9328917264938354 20.069536671104064 65.29511155111815 13.8762040005866 37.501022443857835 28.805009616611883 122.29405260561033 CONFLICT 0.5555555555555556 0.4444444444444444 0.0 GO:0006720 5 isoprenoid metabolic process 36 41 14 14 9 9 5 5 157 36 2349 0.95753 0.11539 0.1815 12.2 24856;25675;298541;65210;65183 ttr;hmgcr;dhdds;cyp2j4;aldh3a2 TTR_10102;HMGCR_8810;DHDDS_8467;CYP2J4_32580;ALDH3A2_8024 31.432538 43.1079 1.63089 20.694986748273603 35.05627959861534 16.352962257219165 22.4694074 28.5876 0.663137 14.674727204576026 24.778022095194924 10.59886028479197 46.32762 63.7146 7.6286 29.106155526314364 50.17287794857001 24.518791904340308 1.5 30.4737 3.5 47.2922 46.6406;1.63089;47.9438;17.8395;43.1079 28.5876;0.663137;36.5688;14.6501;31.8774 63.7146;7.6286;71.3742;22.6149;66.3058 4 1 4 24856;298541;65210;65183 TTR_10102;DHDDS_8467;CYP2J4_32580;ALDH3A2_8024 38.88295 44.87425 14.176942860974409 27.920975 30.2325 9.433957956366987 56.002375 65.0102 22.48447962400953 46.6406;47.9438;17.8395;43.1079 28.5876;36.5688;14.6501;31.8774 63.7146;71.3742;22.6149;66.3058 1 25675 HMGCR_8810 1.63089 1.63089 0.663137 0.663137 7.6286 7.6286 1.63089 0.663137 7.6286 0 Exp 2,1(0.2);Exp 4,1(0.2);Linear,2(0.4);Poly 2,1(0.2) 2.060214035732496 10.906270623207092 1.520427942276001 3.8079800605773926 0.9235384248791947 1.9017701148986816 13.292582312261938 49.57249368773806 9.606441868366598 35.3323729316334 20.814949810356122 71.84029018964387 UP 0.8 0.2 0.0 GO:0001822 5 kidney development 48 53 12 12 6 11 5 5 157 48 2337 0.88316 0.2451 0.38359 9.43 24522;25106;81819;24330;25698 zfp354a;rgn;pax8;egr1;ass1 ZFP354A_10203;RGN_9699;PAX8_9432;EGR1_8533;ASS1_33159 32.544468800000004 26.8037 0.750017 34.12430362673849 29.280573789525807 33.41668603530021 25.0657738 20.9825 0.186019 26.403923870028436 22.60458982891014 26.01234885948639 43.15639 36.7081 2.99857 41.18423863929258 39.7391911764373 41.49504304321006 1.5 13.8192635 0.834827;77.4407;56.8931;0.750017;26.8037 0.27095;58.7732;45.1162;0.186019;20.9825 2.99857;89.8047;81.5688;4.70178;36.7081 2 3 2 25106;81819 RGN_9699;PAX8_9432 67.1669 67.1669 14.529347297108744 51.9447 51.9447 9.656957310664739 85.68674999999999 85.68674999999999 5.823660739174574 77.4407;56.8931 58.7732;45.1162 89.8047;81.5688 3 24522;24330;25698 ZFP354A_10203;EGR1_8533;ASS1_33159 9.462848 0.834827 15.017678224294626 7.1464896666666675 0.27095 11.982411684497006 14.802816666666667 4.70178 18.989636897824912 0.834827;0.750017;26.8037 0.27095;0.186019;20.9825 2.99857;4.70178;36.7081 0 Exp 2,2(0.4);Hill,2(0.4);Poly 2,1(0.2) 2.559382274156275 14.163450360298157 1.7198865413665771 4.591650485992432 1.442611137326655 1.8814297914505005 2.6331978630618913 62.4557397369381 1.92171409072375 48.20983350927625 7.056813177979599 79.25596682202041 DOWN 0.4 0.6 0.0 GO:0055065 8 metal ion homeostasis 139 147 19 19 15 14 11 11 151 136 2249 0.77904 0.33076 0.59947 7.48 24825;29573;25106;24567;288001;81678;81869;304929;24890;29184;155423 tf;slc37a4;rgn;mt1;kng1;itpr2;gstm7;f5;esr1;cd36;anxa7 TF_10003;SLC37A4_9871;RGN_9699;MT1A_9255;KNG1L1_34113;ITPR2_8931;GSTM7_8761;F5_33079;ESR1_33192;CD36_8243;ANXA7_8051 41.864563636363634 39.7166 10.6089 27.97083424591668 47.85670950502822 25.013240559311193 26.95919272727273 24.7342 2.59129 15.829594599465963 31.072601126397252 13.662597298651265 56.651427272727275 60.0334 23.4636 26.255646418402677 63.71009403716026 22.517184684155193 6.5 43.73455 45.1539;39.7166;77.4407;12.9315;24.3655;31.8111;42.3152;10.6089;23.3972;48.1296;104.64 28.132;22.6911;58.7732;8.91033;19.538;24.7342;31.4035;2.59129;18.3088;37.5433;43.9254 61.5341;60.0334;89.8047;23.4636;32.1467;44.3296;64.5991;37.5078;31.9156;69.1421;108.689 5 6 5 24825;25106;81869;29184;155423 TF_10003;RGN_9699;GSTM7_8761;CD36_8243;ANXA7_8051 63.53588 48.1296 26.965072835188135 39.95548 37.5433 12.130710040925067 78.7538 69.1421 20.046801284244825 45.1539;77.4407;42.3152;48.1296;104.64 28.132;58.7732;31.4035;37.5433;43.9254 61.5341;89.8047;64.5991;69.1421;108.689 6 29573;24567;288001;81678;304929;24890 SLC37A4_9871;MT1A_9255;KNG1L1_34113;ITPR2_8931;F5_33079;ESR1_33192 23.805133333333334 23.88135 11.046512302200483 16.128953333333335 18.9234 8.589088672145998 38.23278333333334 34.82725000000001 12.712510792823998 39.7166;12.9315;24.3655;31.8111;10.6089;23.3972 22.6911;8.91033;19.538;24.7342;2.59129;18.3088 60.0334;23.4636;32.1467;44.3296;37.5078;31.9156 0 Exp 2,2(0.19);Exp 3,1(0.1);Hill,1(0.1);Linear,3(0.28);Poly 2,4(0.37) 1.95760024397697 21.87709379196167 1.5461770296096802 2.6703107357025146 0.3797308905209667 1.8344712257385254 25.334856905165367 58.3942703675619 17.60450011773319 36.31388533681226 41.135331774160235 72.16752277129432 CONFLICT 0.45454545454545453 0.5454545454545454 0.0 GO:1901264 6 carbohydrate derivative transport 18 18 5 4 4 3 3 3 159 15 2370 0.97609 0.10206 0.10206 16.67 29573;361074;24360 slc37a4;slc25a30;fabp1 SLC37A4_9871;SLC25A30_9856;FABP1_33091 42.19246666666667 39.7166 33.8478 9.819554958007657 43.842515629554384 9.875216176889108 28.8817 26.4736 22.6911 7.683102096809613 29.771426758821715 8.172144796509352 65.7395 60.0334 46.9257 22.223232704311908 69.46905072207747 22.36331262375538 0.0 33.8478 0.5 36.7822 39.7166;53.013;33.8478 22.6911;37.4804;26.4736 60.0334;90.2594;46.9257 2 1 2 361074;24360 SLC25A30_9856;FABP1_33091 43.4304 43.4304 13.551842882796409 31.977000000000004 31.977000000000004 7.782982919164078 68.59255 68.59255 30.64155312390347 53.013;33.8478 37.4804;26.4736 90.2594;46.9257 1 29573 SLC37A4_9871 39.7166 39.7166 22.6911 22.6911 60.0334 60.0334 39.7166 22.6911 60.0334 0 Exp 2,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 2.3487704236156466 7.417780041694641 1.8753424882888794 3.648852586746216 1.018711218114337 1.893584966659546 31.080594177943667 53.30433915538967 20.18745151494338 37.57594848505663 40.59154480716753 90.88745519283245 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0051385 7 response to mineralocorticoid 32 37 7 7 4 7 4 4 158 33 2352 0.91802 0.20594 0.29228 10.81 25591;294515;314322;114851 parp1;foxo3;fos;cdkn1a PARP1_9425;FOXO3_8662;FOS_8657;CDKN1A_8271 11.605742500000321 9.724435 1.28141E-12 11.577367153972519 13.772785418898392 12.153751340312942 7.47991250000032 4.060325 1.28141E-12 9.82550764069141 9.587328935539553 10.895921853679381 21.77460000000032 25.90935 1.28142E-12 16.171208977891794 24.002052763963427 13.204186852886393 0.5 3.124835000000641 2.5 20.08665 26.9741;13.1992;1.28141E-12;6.24967 21.799;5.6804;1.28141E-12;2.44025 35.2797;32.7581;1.28142E-12;19.0606 1 3 1 25591 PARP1_9425 26.9741 26.9741 21.799 21.799 35.2797 35.2797 26.9741 21.799 35.2797 3 294515;314322;114851 FOXO3_8662;FOS_8657;CDKN1A_8271 6.482956666667094 6.24967 6.602691660347697 2.70688333333376 2.44025 2.8495712029759606 17.27290000000043 19.0606 16.45205708627276 13.1992;1.28141E-12;6.24967 5.6804;1.28141E-12;2.44025 32.7581;1.28142E-12;19.0606 0 Exp 2,1(0.25);Exp 4,2(0.5);Hill,1(0.25) 1.7950290898495076 7.215783476829529 1.522104263305664 1.9883413314819336 0.20170615724161625 1.8526689410209656 0.2599226891072526 22.95156231089339 -2.14908498787726 17.1089099878779 5.926815201666365 37.62238479833428 DOWN 0.25 0.75 0.0 GO:0009112 6 nucleobase metabolic process 12 15 2 2 2 2 2 2 160 13 2372 0.93468 0.24652 0.24652 13.33 24856;497840 ttr;cps1 TTR_10102;CPS1_32421 39.3116 39.3116 31.9826 10.364771198632425 40.01323223961229 10.31716561855406 26.5356 26.5356 24.4836 2.901966229989618 26.732045539048222 2.8886374470286706 54.651849999999996 54.651849999999996 45.5891 12.81666396239678 55.51946053070628 12.75779679486291 0.0 31.9826 0.5 39.3116 46.6406;31.9826 28.5876;24.4836 63.7146;45.5891 1 1 1 24856 TTR_10102 46.6406 46.6406 28.5876 28.5876 63.7146 63.7146 46.6406 28.5876 63.7146 1 497840 CPS1_32421 31.9826 31.9826 24.4836 24.4836 45.5891 45.5891 31.9826 24.4836 45.5891 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.875017691790385 3.751325488090515 1.8264755010604858 1.9248499870300293 0.06956126612480505 1.8756627440452576 24.946760000000005 53.67643999999999 22.51368 30.557519999999997 36.888859999999994 72.41484 CONFLICT 0.5 0.5 0.0 GO:0048291 12 isotype switching to IgG isotypes 1 1 1 1 1 1 1 1 161 0 2385 1.0 0.063604 0.063604 100.0 63868 hspd1 HSPD1_8849 42.2579 42.2579 42.2579 42.2579 23.9469 23.9469 23.9469 23.9469 102.383 102.383 102.383 102.383 0.0 42.2579 0.0 42.2579 42.2579 23.9469 102.383 1 0 1 63868 HSPD1_8849 42.2579 42.2579 23.9469 23.9469 102.383 102.383 42.2579 23.9469 102.383 0 0 Exp 3,1(1) 2.2518506050109863 2.2518506050109863 2.2518506050109863 2.2518506050109863 0.0 2.2518506050109863 42.2579 42.2579 23.9469 23.9469 102.383 102.383 UP 1.0 0.0 0.0 GO:1903611 8 negative regulation of calcium-dependent ATPase activity 1 1 1 1 1 1 1 1 161 0 2385 1.0 0.063604 0.063604 100.0 25106 rgn RGN_9699 77.4407 77.4407 77.4407 77.4407 58.7732 58.7732 58.7732 58.7732 89.8047 89.8047 89.8047 89.8047 0.0 77.4407 0.0 77.4407 77.4407 58.7732 89.8047 1 0 1 25106 RGN_9699 77.4407 77.4407 58.7732 58.7732 89.8047 89.8047 77.4407 58.7732 89.8047 0 0 Poly 2,1(1) 1.7198865413665771 1.7198865413665771 1.7198865413665771 1.7198865413665771 0.0 1.7198865413665771 77.4407 77.4407 58.7732 58.7732 89.8047 89.8047 UP 1.0 0.0 0.0 GO:1903634 8 negative regulation of leucine-tRNA ligase activity 1 1 1 1 1 1 1 1 161 0 2385 1.0 0.063604 0.063604 100.0 25106 rgn RGN_9699 77.4407 77.4407 77.4407 77.4407 58.7732 58.7732 58.7732 58.7732 89.8047 89.8047 89.8047 89.8047 0.0 77.4407 0.0 77.4407 77.4407 58.7732 89.8047 1 0 1 25106 RGN_9699 77.4407 77.4407 58.7732 58.7732 89.8047 89.8047 77.4407 58.7732 89.8047 0 0 Poly 2,1(1) 1.7198865413665771 1.7198865413665771 1.7198865413665771 1.7198865413665771 0.0 1.7198865413665771 77.4407 77.4407 58.7732 58.7732 89.8047 89.8047 UP 1.0 0.0 0.0 GO:0009108 6 coenzyme biosynthetic process 28 33 7 7 4 6 3 3 159 30 2355 0.8458 0.35094 0.46366 9.09 25106;298490;100359982 rgn;ppcs;mpc2 RGN_9699;PPCS_9540;MPC2_33219 48.207433333333334 46.8463 20.3353 28.57702206762164 49.90759501412429 28.753771770190454 37.12896666666666 35.8494 16.7643 21.033660830757295 38.38344322740113 21.17532395606665 61.53426666666667 69.127 25.6711 32.73403216597878 63.31999451977401 32.53582281954595 0.5 33.5908 77.4407;20.3353;46.8463 58.7732;16.7643;35.8494 89.8047;25.6711;69.127 3 0 3 25106;298490;100359982 RGN_9699;PPCS_9540;MPC2_33219 48.207433333333334 46.8463 28.57702206762164 37.12896666666666 35.8494 21.033660830757295 61.53426666666667 69.127 32.73403216597878 77.4407;20.3353;46.8463 58.7732;16.7643;35.8494 89.8047;25.6711;69.127 0 0 Exp 2,2(0.67);Poly 2,1(0.34) 1.986667118209266 6.013838410377502 1.7198865413665771 2.371572256088257 0.3335345423077432 1.9223796129226685 15.869488621910058 80.5453780447566 13.327138771011889 60.93079456232144 24.492222192594816 98.57631114073851 UP 1.0 0.0 0.0 GO:0014823 3 response to activity 61 66 9 9 6 8 5 5 157 61 2324 0.75984 0.41133 0.60862 7.58 83516;63868;113965;25661;29184 ppargc1a;hspd1;hadh;fn1;cd36 PPARGC1A_33189;HSPD1_8849;HADH_8776;FN1_8655;CD36_8243 45.137420000000006 42.4094 33.3125 9.65708663609266 46.55785906647507 10.253010526833137 28.914499999999997 26.2988 23.9469 5.492112154262708 29.727869285220077 5.603061749796725 81.09684 81.7305 46.9856 24.202436231152415 81.75974810793548 24.52950081902562 2.5 45.2695 42.4094;42.2579;33.3125;59.5777;48.1296 26.2988;23.9469;25.7336;31.0499;37.5433 81.7305;102.383;46.9856;105.243;69.1421 3 2 3 63868;113965;29184 HSPD1_8849;HADH_8776;CD36_8243 41.23333333333334 42.2579 7.461495543343345 29.0746 25.7336 7.388317399110584 72.8369 69.1421 27.88290949614119 42.2579;33.3125;48.1296 23.9469;25.7336;37.5433 102.383;46.9856;69.1421 2 83516;25661 PPARGC1A_33189;FN1_8655 50.99355 50.99355 12.139821351444999 28.67435 28.67435 3.3595350280954177 93.48675 93.48675 16.625848192648668 42.4094;59.5777 26.2988;31.0499 81.7305;105.243 0 Exp 2,2(0.4);Exp 3,1(0.2);Linear,1(0.2);Power,1(0.2) 2.058198247084639 10.423173785209656 1.7576230764389038 2.6703107357025146 0.3826549339311421 1.9641557931900024 36.672610344300054 53.602229655699944 24.100451442142194 33.728548557857806 59.88246928748741 102.31121071251256 UP 0.6 0.4 0.0 GO:0045861 8 negative regulation of proteolysis 111 119 18 18 16 18 16 16 146 103 2282 0.99892 0.0028945 0.0032253 13.45 79224;24794;24648;252922;29441;25513;299282;288001;54404;50693;306251;83928;24360;113936;25377;25373 serpind1;serpina3c;serpina1;pzp;por;pik3r1;loc299282;kng1;itih4;itih3;itih1;fetub;fabp1;cpb2;ambp;ahsg SERPIND1_9812;SERPINA3C_32925;SERPINA1_9807;PZP_9633;POR_9531;PIK3R1_32562;LOC299282_9119;KNG1L1_34113;ITIH4_32725;ITIH3_32422;ITIH1_33132;FETUB_33027;FABP1_33091;CPB2_8369;AMBP_33085;AHSG_8003 32.0624 27.69285 12.402 21.22076508177781 39.30612898322927 25.5980757558212 21.901481875 20.9741 8.48981 9.826780746344287 24.917261348147726 11.421342516184815 49.4331625 41.2117 15.4235 27.363331317875634 61.75562270177514 29.450832039167377 4.5 21.548949999999998 10.5 33.181650000000005 28.261;29.766;15.797;34.1871;12.4414;18.7324;45.2017;24.3655;57.1163;27.1247;98.1741;32.5155;33.8478;25.8316;17.2343;12.402 22.307;23.347;13.013;26.3085;8.48981;11.6701;30.7472;19.538;39.6402;21.5108;42.9071;19.6094;26.4736;20.4374;14.1233;10.3013 38.3264;40.8256;19.9134;48.5666;79.2355;41.5978;78.6415;32.1467;101.869;36.4819;104.278;49.9875;46.9257;34.8042;21.9073;15.4235 1 15 1 24360 FABP1_33091 33.8478 33.8478 26.4736 26.4736 46.9257 46.9257 33.8478 26.4736 46.9257 15 79224;24794;24648;252922;29441;25513;299282;288001;54404;50693;306251;83928;113936;25377;25373 SERPIND1_9812;SERPINA3C_32925;SERPINA1_9807;PZP_9633;POR_9531;PIK3R1_32562;LOC299282_9119;KNG1L1_34113;ITIH4_32725;ITIH3_32422;ITIH1_33132;FETUB_33027;CPB2_8369;AMBP_33085;AHSG_8003 31.943373333333337 27.1247 21.960049597376543 21.596674 20.4374 10.093089629585892 49.60032666666667 40.8256 28.315281066324456 28.261;29.766;15.797;34.1871;12.4414;18.7324;45.2017;24.3655;57.1163;27.1247;98.1741;32.5155;25.8316;17.2343;12.402 22.307;23.347;13.013;26.3085;8.48981;11.6701;30.7472;19.538;39.6402;21.5108;42.9071;19.6094;20.4374;14.1233;10.3013 38.3264;40.8256;19.9134;48.5666;79.2355;41.5978;78.6415;32.1467;101.869;36.4819;104.278;49.9875;34.8042;21.9073;15.4235 0 Exp 2,6(0.38);Exp 3,1(0.07);Linear,6(0.38);Poly 2,3(0.19) 1.8746878083211955 30.90140390396118 1.5197933912277222 3.431420087814331 0.5423759353514828 1.6763167977333069 21.664225109928868 42.460574890071115 17.086359309291296 26.7166044407087 36.02513015424094 62.84119484575906 DOWN 0.0625 0.9375 0.0 GO:0061687 3 detoxification of inorganic compound 2 4 2 2 2 2 2 2 160 2 2383 0.99904 0.022157 0.022157 50.0 24567;25303 mt1;abcc2 MT1A_9255;ABCC2_32541 29.58155 29.58155 12.9315 23.546726524190152 34.36996683734426 22.55195021253542 20.044565 20.044565 8.91033 15.746186143649197 23.246679008363202 15.080958518122712 52.6242 52.6242 23.4636 41.239316006936875 61.010547670250894 39.497082553365345 0.0 12.9315 0.0 12.9315 12.9315;46.2316 8.91033;31.1788 23.4636;81.7848 0 2 0 2 24567;25303 MT1A_9255;ABCC2_32541 29.58155 29.58155 23.546726524190152 20.044565 20.044565 15.746186143649197 52.6242 52.6242 41.239316006936875 12.9315;46.2316 8.91033;31.1788 23.4636;81.7848 0 Exp 2,1(0.5);Poly 2,1(0.5) 2.055758630736549 4.132349967956543 1.8589661121368408 2.273383855819702 0.2930375968021798 2.0661749839782715 -3.0525480000000016 62.215648 -1.7785356000000014 41.867665599999995 -4.530575999999996 109.778976 DOWN 0.0 1.0 0.0 GO:0071901 9 negative regulation of protein serine/threonine kinase activity 40 43 5 5 5 5 5 5 157 38 2347 0.9481 0.1342 0.19203 11.63 24471;25675;25112;116663;114851 hspb1;hmgcr;gadd45a;dusp6;cdkn1a HSPB1_8847;HMGCR_8810;GADD45A_8678;DUSP6_8506;CDKN1A_8271 52.458812 62.3934 1.63089 46.65390214337455 61.459238481029196 46.07101113946106 38.4037174 39.0875 0.663137 38.11086157510728 46.33223206301835 39.29400599292274 76.31364 106.138 7.6286 58.44565037081886 83.81340201136288 52.72078664297294 1.5 34.321535 3.5 96.01005 89.1011;1.63089;102.919;62.3934;6.24967 60.3265;0.663137;89.5012;39.0875;2.44025 106.138;7.6286;115.437;133.304;19.0606 0 5 0 5 24471;25675;25112;116663;114851 HSPB1_8847;HMGCR_8810;GADD45A_8678;DUSP6_8506;CDKN1A_8271 52.458812 62.3934 46.65390214337455 38.4037174 39.0875 38.11086157510728 76.31364 106.138 58.44565037081886 89.1011;1.63089;102.919;62.3934;6.24967 60.3265;0.663137;89.5012;39.0875;2.44025 106.138;7.6286;115.437;133.304;19.0606 0 Exp 2,1(0.2);Exp 4,2(0.4);Poly 2,2(0.4) 1.6736427284801634 8.39086389541626 1.522104263305664 1.9017701148986816 0.14006905163657984 1.6357084512710571 11.564863729582207 93.3527602704178 4.9980743520943705 71.80936044790565 25.083768690411993 127.54351130958801 DOWN 0.0 1.0 0.0 GO:0010890 6 positive regulation of sequestering of triglyceride 4 4 2 2 2 2 2 2 160 2 2383 0.99904 0.022157 0.022157 50.0 298199;24539 plin2;lpl PLIN2_9502;LPL_32544 49.9279 49.9279 25.6517 34.33173128288173 67.59212612673998 23.55032916047661 35.3967 35.3967 20.9252 20.465791567882242 45.92667785457024 14.038794722643424 94.23125 94.23125 33.0375 86.54103118246861 138.75799790713523 59.36402546790307 0.0 25.6517 0.0 25.6517 25.6517;74.2041 20.9252;49.8682 33.0375;155.425 2 0 2 298199;24539 PLIN2_9502;LPL_32544 49.9279 49.9279 34.33173128288173 35.3967 35.3967 20.465791567882242 94.23125 94.23125 86.54103118246861 25.6517;74.2041 20.9252;49.8682 33.0375;155.425 0 0 Exp 2,2(1) 1.8730257107135198 3.8091280460357666 1.559399127960205 2.2497289180755615 0.4881368758456546 1.9045640230178833 2.3465479999999985 97.50925199999999 7.032560000000004 63.76084 -25.708499999999987 214.17100000000002 UP 1.0 0.0 0.0 GO:0071869 5 response to catecholamine 18 20 4 4 4 3 3 3 159 17 2368 0.96571 0.13018 0.13018 15.0 83516;24651;24330 ppargc1a;pklr;egr1 PPARGC1A_33189;PKLR_9489;EGR1_8533 22.085239 23.0963 0.750017 20.848086992442802 20.963811617549666 21.75225912015497 14.649106333333334 17.4625 0.186019 13.281781538303523 13.750707058682854 13.88081105957941 39.79219333333334 32.9443 4.70178 38.968271177178664 38.50043195732157 40.32765130378284 0.0 0.750017 1.0 23.0963 42.4094;23.0963;0.750017 26.2988;17.4625;0.186019 81.7305;32.9443;4.70178 0 3 0 3 83516;24651;24330 PPARGC1A_33189;PKLR_9489;EGR1_8533 22.085239 23.0963 20.848086992442802 14.649106333333334 17.4625 13.281781538303523 39.79219333333334 32.9443 38.968271177178664 42.4094;23.0963;0.750017 26.2988;17.4625;0.186019 81.7305;32.9443;4.70178 0 Exp 2,2(0.67);Hill,1(0.34) 2.714158191868271 8.672677636146545 1.7576230764389038 4.21828556060791 1.2417640390449196 2.6967689990997314 -1.506592328864162 45.67707032886415 -0.3806443537230564 29.67885702038972 -4.3045567005036105 83.88894336717027 DOWN 0.0 1.0 0.0 GO:1901214 6 regulation of neuron death 149 157 16 16 14 15 13 13 149 144 2241 0.87982 0.19433 0.30943 8.28 83516;25591;24314;24567;24516;192235;63868;294515;314322;24890;29496;24330;140942 ppargc1a;parp1;nqo1;mt1;jun;hyou1;hspd1;foxo3;fos;esr1;erbb3;egr1;ddit4 PPARGC1A_33189;PARP1_9425;NQO1_33055;MT1A_9255;JUN_8938;HYOU1_8857;HSPD1_8849;FOXO3_8662;FOS_8657;ESR1_33192;ERBB3_8571;EGR1_8533;DDIT4_8450 34.95130130769241 26.9741 1.28141E-12 29.166389071606574 32.648576454181644 24.313703576253086 23.121934538461637 21.799 1.28141E-12 19.282014719736225 21.67676316378602 15.953589464222784 74.6999523076924 39.929 1.28142E-12 74.2315423617316 65.85982177532503 58.33914120143655 6.5 33.58615 42.4094;26.9741;87.2765;12.9315;16.4324;40.1982;42.2579;13.1992;1.28141E-12;23.3972;60.9984;0.750017;87.5421 26.2988;21.799;60.6992;8.91033;10.5224;29.3844;23.9469;5.6804;1.28141E-12;18.3088;41.6036;0.186019;53.2453 81.7305;35.2797;197.117;23.4636;39.929;62.3571;102.383;32.7581;1.28142E-12;31.9156;113.972;4.70178;245.492 4 9 4 25591;24314;63868;29496 PARP1_9425;NQO1_33055;HSPD1_8849;ERBB3_8571 54.376725 51.62815 25.97442043708579 37.012175 32.77525 18.11351651196329 112.187925 108.1775 66.40065845774798 26.9741;87.2765;42.2579;60.9984 21.799;60.6992;23.9469;41.6036 35.2797;197.117;102.383;113.972 9 83516;24567;24516;192235;294515;314322;24890;24330;140942 PPARGC1A_33189;MT1A_9255;JUN_8938;HYOU1_8857;FOXO3_8662;FOS_8657;ESR1_33192;EGR1_8533;DDIT4_8450 26.31777966666681 16.4324 27.395026603270757 16.948494333333475 10.5224 17.184648899977304 58.03863111111124 32.7581 74.81387842798081 42.4094;12.9315;16.4324;40.1982;13.1992;1.28141E-12;23.3972;0.750017;87.5421 26.2988;8.91033;10.5224;29.3844;5.6804;1.28141E-12;18.3088;0.186019;53.2453 81.7305;23.4636;39.929;62.3571;32.7581;1.28142E-12;31.9156;4.70178;245.492 0 Exp 2,5(0.39);Exp 3,1(0.08);Exp 4,1(0.08);Hill,2(0.16);Linear,2(0.16);Poly 2,2(0.16) 2.008937331715452 27.10765564441681 1.576730489730835 4.21828556060791 0.6971411398256027 1.8966681957244873 19.09627160131489 50.80633101406992 12.6401119367793 33.60375714014397 34.347226215821564 115.05267839956326 DOWN 0.3076923076923077 0.6923076923076923 0.0 GO:0045639 7 positive regulation of myeloid cell differentiation 40 45 3 3 3 3 3 3 159 42 2343 0.67961 0.55361 0.76174 6.67 24516;294515;314322 jun;foxo3;fos JUN_8938;FOXO3_8662;FOS_8657 9.877200000000427 13.1992 1.28141E-12 8.705326268439762 10.554234598502855 8.859444167303028 5.400933333333761 5.6804 1.28141E-12 5.266763869144543 6.127519597211864 5.568166941931938 24.22903333333376 32.7581 1.28142E-12 21.287085143422107 25.801683617351294 21.600133360098354 1.5 14.8158 16.4324;13.1992;1.28141E-12 10.5224;5.6804;1.28141E-12 39.929;32.7581;1.28142E-12 0 3 0 3 24516;294515;314322 JUN_8938;FOXO3_8662;FOS_8657 9.877200000000427 13.1992 8.705326268439762 5.400933333333761 5.6804 5.266763869144543 24.22903333333376 32.7581 21.287085143422107 16.4324;13.1992;1.28141E-12 10.5224;5.6804;1.28141E-12 39.929;32.7581;1.28142E-12 0 Exp 4,1(0.34);Hill,1(0.34);Poly 2,1(0.34) 1.9540689336105495 5.863515377044678 1.8966681957244873 1.9883413314819336 0.05032908726507177 1.9785058498382568 0.026195969644682293 19.72820403035617 -0.5589710403794834 11.360837707047004 0.14042883121197036 48.31763783545555 DOWN 0.0 1.0 0.0 GO:0002224 6 toll-like receptor signaling pathway 21 23 2 2 2 2 2 2 160 21 2364 0.82335 0.43545 0.65454 8.7 25493;63868 nfkbia;hspd1 NFKBIA_9307;HSPD1_8849 21.3890255 21.3890255 0.520151 29.51304534936204 34.97419842130817 22.403258673456655 12.053551 12.053551 0.160202 16.819735457836483 19.795856545920433 12.767807585440082 52.633995 52.633995 2.88499 70.35571758556691 85.01949023061363 53.406801011817315 0.5 21.3890255 0.520151;42.2579 0.160202;23.9469 2.88499;102.383 1 1 1 63868 HSPD1_8849 42.2579 42.2579 23.9469 23.9469 102.383 102.383 42.2579 23.9469 102.383 1 25493 NFKBIA_9307 0.520151 0.520151 0.160202 0.160202 2.88499 2.88499 0.520151 0.160202 2.88499 0 Exp 3,1(0.5);Exp 4,1(0.5) 2.043598782661202 4.106456756591797 1.8546061515808105 2.2518506050109863 0.280894246809221 2.0532283782958984 -19.513968519999995 62.29201952 -11.25741304 35.36451504 -44.874054799999996 150.1420448 CONFLICT 0.5 0.5 0.0 GO:0019220 7 regulation of phosphate metabolic process 435 462 35 35 28 31 24 24 138 438 1947 0.15124 0.89478 0.29234 5.19 246273;24825;293615;25106;192280;83516;25513;25591;24516;24471;25675;29455;299626;25112;25661;361969;24890;29496;24330;116663;140942;114851;29184;25373 trib3;tf;sirt3;rgn;ppp1r3b;ppargc1a;pik3r1;parp1;jun;hspb1;hmgcr;gdf15;gadd45b;gadd45a;fn1;fga;esr1;erbb3;egr1;dusp6;ddit4;cdkn1a;cd36;ahsg TRIB3_10079;TF_10003;SIRT3_9828;RGN_9699;PPP1R3B_9545;PPARGC1A_33189;PIK3R1_32562;PARP1_9425;JUN_8938;HSPB1_8847;HMGCR_8810;GDF15_33113;GADD45B_8679;GADD45A_8678;FN1_8655;FGA_8632;ESR1_33192;ERBB3_8571;EGR1_8533;DUSP6_8506;DDIT4_8450;CDKN1A_8271;CD36_8243;AHSG_8003 48.704814875000004 43.78165 0.750017 36.62152531738984 49.38499883199925 34.44974279577302 33.89782066666667 27.5954 0.186019 27.176068563441323 35.41478470847377 27.305515634254 74.88136041666668 65.3381 4.70178 56.91327202042467 72.61287895497996 47.04472622911828 22.5 107.21549999999999 108.064;45.1539;2.38018;77.4407;36.1411;42.4094;18.7324;26.9741;16.4324;89.1011;1.63089;105.149;106.367;102.919;59.5777;28.5803;23.3972;60.9984;0.750017;62.3934;87.5421;6.24967;48.1296;12.402 83.8836;28.132;0.56209;58.7732;27.0588;26.2988;11.6701;21.799;10.5224;60.3265;0.663137;85.3487;52.7132;89.5012;31.0499;22.529;18.3088;41.6036;0.186019;39.0875;53.2453;2.44025;37.5433;10.3013 143.428;61.5341;8.82917;89.8047;53.6244;81.7305;41.5978;35.2797;39.929;106.138;7.6286;125.652;109.434;115.437;105.243;38.8511;31.9156;113.972;4.70178;133.304;245.492;19.0606;69.1421;15.4235 7 17 7 24825;293615;25106;25591;299626;29496;29184 TF_10003;SIRT3_9828;RGN_9699;PARP1_9425;GADD45B_8679;ERBB3_8571;CD36_8243 52.491982857142865 48.1296 33.74548875316606 34.446627142857146 37.5433 19.72418278773945 69.71368142857143 69.1421 38.51408089694487 45.1539;2.38018;77.4407;26.9741;106.367;60.9984;48.1296 28.132;0.56209;58.7732;21.799;52.7132;41.6036;37.5433 61.5341;8.82917;89.8047;35.2797;109.434;113.972;69.1421 17 246273;192280;83516;25513;24516;24471;25675;29455;25112;25661;361969;24890;24330;116663;140942;114851;25373 TRIB3_10079;PPP1R3B_9545;PPARGC1A_33189;PIK3R1_32562;JUN_8938;HSPB1_8847;HMGCR_8810;GDF15_33113;GADD45A_8678;FN1_8655;FGA_8632;ESR1_33192;EGR1_8533;DUSP6_8506;DDIT4_8450;CDKN1A_8271;AHSG_8003 47.14539276470588 36.1411 38.626289274873066 33.67184152941177 26.2988 30.25842174873664 77.00922823529412 53.6244 63.902199867274156 108.064;36.1411;42.4094;18.7324;16.4324;89.1011;1.63089;105.149;102.919;59.5777;28.5803;23.3972;0.750017;62.3934;87.5421;6.24967;12.402 83.8836;27.0588;26.2988;11.6701;10.5224;60.3265;0.663137;85.3487;89.5012;31.0499;22.529;18.3088;0.186019;39.0875;53.2453;2.44025;10.3013 143.428;53.6244;81.7305;41.5978;39.929;106.138;7.6286;125.652;115.437;105.243;38.8511;31.9156;4.70178;133.304;245.492;19.0606;15.4235 0 Exp 2,7(0.3);Exp 4,2(0.09);Hill,2(0.09);Linear,3(0.13);Poly 2,8(0.34);Power,2(0.09) 1.8822961676694978 46.90159034729004 1.5209722518920898 4.21828556060791 0.6475619088795895 1.7387548089027405 34.05315327209659 63.356476477903406 23.025128804764094 44.770512528569256 52.11130932976434 97.651411503569 DOWN 0.2916666666666667 0.7083333333333334 0.0 GO:0008584 6 male gonad development 41 45 5 5 4 4 3 3 159 42 2343 0.67961 0.55361 0.76174 6.67 24890;25146;25373 esr1;cyp17a1;ahsg ESR1_33192;CYP17A1_32365;AHSG_8003 28.497133333333334 23.3972 12.402 19.161073665463885 27.46484250553778 20.266621748563573 21.425166666666666 18.3088 10.3013 12.966040185937008 20.658297378784148 13.753897858668013 42.99333333333334 31.9156 15.4235 34.47061281067299 41.531447231110015 36.21185311202073 1.5 36.5447 23.3972;49.6922;12.402 18.3088;35.6654;10.3013 31.9156;81.6409;15.4235 1 2 1 25146 CYP17A1_32365 49.6922 49.6922 35.6654 35.6654 81.6409 81.6409 49.6922 35.6654 81.6409 2 24890;25373 ESR1_33192;AHSG_8003 17.8996 17.8996 7.774780480502335 14.305050000000001 14.305050000000001 5.662157550351277 23.66955 23.66955 11.661675746006662 23.3972;12.402 18.3088;10.3013 31.9156;15.4235 0 Exp 2,2(0.67);Linear,1(0.34) 2.5181118856402414 7.777811527252197 1.90940523147583 3.431420087814331 0.7728485892100011 2.436986207962036 6.814337297446404 50.17992936922026 6.752710954985163 36.09762237834817 3.986162866001429 82.00050380066523 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:1900372 9 negative regulation of purine nucleotide biosynthetic process 1 1 1 1 1 1 1 1 161 0 2385 1.0 0.063604 0.063604 100.0 25591 parp1 PARP1_9425 26.9741 26.9741 26.9741 26.974100000000004 21.799 21.799 21.799 21.799 35.2797 35.2797 35.2797 35.2797 0.0 26.9741 0.0 26.9741 26.9741 21.799 35.2797 1 0 1 25591 PARP1_9425 26.9741 26.9741 21.799 21.799 35.2797 35.2797 26.9741 21.799 35.2797 0 0 Exp 2,1(1) 1.8086696863174438 1.8086696863174438 1.8086696863174438 1.8086696863174438 0.0 1.8086696863174438 26.9741 26.9741 21.799 21.799 35.2797 35.2797 UP 1.0 0.0 0.0 GO:0000070 6 mitotic sister chromatid segregation 13 13 2 2 1 2 1 1 161 12 2373 0.80158 0.57532 0.57532 7.69 257644 zwint ZWINT_10214 52.0003 52.0003 52.0003 52.0003 38.9015 38.9015 38.9015 38.9015 80.8613 80.8613 80.8613 80.8613 0.0 52.0003 52.0003 38.9015 80.8613 1 0 1 257644 ZWINT_10214 52.0003 52.0003 38.9015 38.9015 80.8613 80.8613 52.0003 38.9015 80.8613 0 0 Exp 2,1(1) 1.5207922458648682 1.5207922458648682 1.5207922458648682 1.5207922458648682 0.0 1.5207922458648682 52.0003 52.0003 38.9015 38.9015 80.8613 80.8613 UP 1.0 0.0 0.0 GO:0009758 2 carbohydrate utilization 1 1 1 1 1 1 1 1 161 0 2385 1.0 0.063604 0.063604 100.0 25351 slc2a2 SLC2A2_9863 29.7555 29.7555 29.7555 29.755500000000005 23.3399 23.3399 23.3399 23.3399 40.808 40.808 40.808 40.808 0.0 29.7555 0.0 29.7555 29.7555 23.3399 40.808 0 1 0 1 25351 SLC2A2_9863 29.7555 29.7555 23.3399 23.3399 40.808 40.808 29.7555 23.3399 40.808 0 Linear,1(1) 1.7682682275772095 1.7682682275772095 1.7682682275772095 1.7682682275772095 0.0 1.7682682275772095 29.7555 29.7555 23.3399 23.3399 40.808 40.808 DOWN 0.0 1.0 0.0 GO:0033140 9 negative regulation of peptidyl-serine phosphorylation of STAT protein 2 2 1 1 1 1 1 1 161 1 2384 0.99598 0.12319 0.12319 50.0 25112 gadd45a GADD45A_8678 102.919 102.919 102.919 102.919 89.5012 89.5012 89.5012 89.5012 115.437 115.437 115.437 115.437 0.0 102.919 0.0 102.919 102.919 89.5012 115.437 0 1 0 1 25112 GADD45A_8678 102.919 102.919 89.5012 89.5012 115.437 115.437 102.919 89.5012 115.437 0 Poly 2,1(1) 1.6339634656906128 1.6339634656906128 1.6339634656906128 1.6339634656906128 0.0 1.6339634656906128 102.919 102.919 89.5012 89.5012 115.437 115.437 DOWN 0.0 1.0 0.0 GO:0061178 6 regulation of insulin secretion involved in cellular response to glucose stimulus 18 19 2 2 2 2 2 2 160 17 2368 0.88421 0.34304 0.34304 10.53 100359982;25675 mpc2;hmgcr MPC2_33219;HMGCR_8810 24.238595 24.238595 1.63089 31.972123025130035 37.942391000349765 25.42889303716633 18.2562685 18.2562685 0.663137 24.88044517191332 28.920450692899617 19.788557003123557 38.3778 38.3778 7.6286 43.48593567212277 57.01661203217908 34.58635530578777 0.0 1.63089 0.5 24.238595 46.8463;1.63089 35.8494;0.663137 69.127;7.6286 1 1 1 100359982 MPC2_33219 46.8463 46.8463 35.8494 35.8494 69.127 69.127 46.8463 35.8494 69.127 1 25675 HMGCR_8810 1.63089 1.63089 0.663137 0.663137 7.6286 7.6286 1.63089 0.663137 7.6286 0 Exp 2,1(0.5);Exp 4,1(0.5) 1.9120470960064835 3.82414972782135 1.9017701148986816 1.9223796129226685 0.01457311580961183 1.912074863910675 -20.072506799999996 68.54969679999999 -16.226269239999997 52.73880624 -21.89063199999999 98.64623199999997 CONFLICT 0.5 0.5 0.0 GO:0043648 7 dicarboxylic acid metabolic process 32 33 7 7 4 7 4 4 158 29 2356 0.94539 0.1542 0.1542 12.12 24552;24957;25146;25698 me1;glul;cyp17a1;ass1 ME1_9215;GLUL_32832;CYP17A1_32365;ASS1_33159 45.9393 38.24795 26.4669 25.653510504022627 35.718703248393844 18.791065316415242 34.387375 28.3555 20.9825 18.330101301843197 27.136048119540895 13.134249693146266 61.960350000000005 59.1745 35.4303 30.328018313269318 50.025901934599005 25.764448804317308 0.5 26.6353 2.5 65.2433 80.7944;26.4669;49.6922;26.8037 59.856;21.0456;35.6654;20.9825 94.0621;35.4303;81.6409;36.7081 1 3 1 25146 CYP17A1_32365 49.6922 49.6922 35.6654 35.6654 81.6409 81.6409 49.6922 35.6654 81.6409 3 24552;24957;25698 ME1_9215;GLUL_32832;ASS1_33159 44.68833333333333 26.8037 31.269224425356843 33.96136666666667 21.0456 22.42543248196862 55.40016666666667 36.7081 33.48831154318374 80.7944;26.4669;26.8037 59.856;21.0456;20.9825 94.0621;35.4303;36.7081 0 Exp 2,1(0.25);Linear,2(0.5);Poly 2,1(0.25) 2.1191985962420667 8.529786467552185 1.8814297914505005 2.376685380935669 0.273999062195047 2.135835647583008 20.79885970605781 71.0797402939422 16.423875724193675 52.35087427580632 32.238892052996064 91.68180794700395 DOWN 0.25 0.75 0.0 GO:0044087 5 regulation of cellular component biogenesis 211 228 8 8 7 8 7 7 155 221 2164 0.016745 0.99332 0.032042 3.07 293615;25513;25591;24890;116636;29184;246142 sirt3;pik3r1;parp1;esr1;eif4ebp1;cd36;bmf SIRT3_9828;PIK3R1_32562;PARP1_9425;ESR1_33192;EIF4EBP1_8550;CD36_8243;BMF_8152 42.62718285714285 26.9741 2.38018 34.80741170102603 51.48244943777637 35.708487846845834 29.347998571428572 21.799 0.56209 24.066644702291754 36.23861488757868 25.548632571689595 57.704624285714296 41.5978 8.82917 39.00346952922002 67.10789902505792 39.58103592018354 2.38018;18.7324;26.9741;23.3972;83.9001;48.1296;94.8767 0.56209;11.6701;21.799;18.3088;42.4185;37.5433;73.1342 8.82917;41.5978;35.2797;31.9156;107.32;69.1421;109.848 5 2 5 293615;25591;116636;29184;246142 SIRT3_9828;PARP1_9425;EIF4EBP1_8550;CD36_8243;BMF_8152 51.25213599999999 48.1296 38.58961480725715 35.091418 37.5433 26.813774383208724 66.083794 69.1421 44.30594718606272 2.38018;26.9741;83.9001;48.1296;94.8767 0.56209;21.799;42.4185;37.5433;73.1342 8.82917;35.2797;107.32;69.1421;109.848 2 25513;24890 PIK3R1_32562;ESR1_33192 21.064799999999998 21.064799999999998 3.2985117128790176 14.989450000000001 14.989450000000001 4.694269788263129 36.7567 36.7567 6.846349276804378 18.7324;23.3972 11.6701;18.3088 41.5978;31.9156 0 Exp 2,3(0.43);Exp 3,1(0.15);Hill,1(0.15);Poly 2,2(0.29) 1.8872148062515175 13.484549522399902 1.5209722518920898 2.6703107357025146 0.4418262638124801 1.701177716255188 16.841491417171568 68.41287429711414 11.519178674704627 47.17681846815252 28.810449705673808 86.59879886575476 UP 0.7142857142857143 0.2857142857142857 0.0 GO:0001816 5 cytokine production 29 29 2 2 2 2 2 2 160 27 2358 0.72053 0.55973 0.70682 6.9 29573;63868 slc37a4;hspd1 SLC37A4_9871;HSPD1_8849 40.98725 40.98725 39.7166 1.7969704630291043 40.83956399797863 1.7847914540958352 23.319 23.319 22.6911 0.8879846958139613 23.24601999711233 0.8819663589712721 81.2082 81.2082 60.0334 29.94568934053777 78.74708045047646 29.7427317374499 0.5 40.98725 39.7166;42.2579 22.6911;23.9469 60.0334;102.383 1 1 1 63868 HSPD1_8849 42.2579 42.2579 23.9469 23.9469 102.383 102.383 42.2579 23.9469 102.383 1 29573 SLC37A4_9871 39.7166 39.7166 22.6911 22.6911 60.0334 60.0334 39.7166 22.6911 60.0334 0 Exp 3,1(0.5);Poly 2,1(0.5) 2.0649625790343045 4.145435571670532 1.893584966659546 2.2518506050109863 0.25333206234443073 2.072717785835266 38.496776000000004 43.477724 22.088316 24.549684 39.70559200000002 122.71080799999999 CONFLICT 0.5 0.5 0.0 GO:0045833 6 negative regulation of lipid metabolic process 31 34 6 6 4 6 4 4 158 30 2355 0.93913 0.16664 0.27209 11.76 246273;24890;25428;25287 trib3;esr1;cyp7a1;acadl TRIB3_10079;ESR1_33192;CYP7A1_8430;ACADL_32776 42.66757 28.442500000000003 5.72128 45.082652756534486 60.27089127585109 48.38338961116363 32.44539325 22.45635 0.985273 35.91468869374547 46.59226715441723 38.01221996295368 60.757225 38.6192 22.3625 55.9126484039986 82.0613229716831 61.53232263134359 0.5 14.55924 2.5 70.7759 108.064;23.3972;5.72128;33.4878 83.8836;18.3088;0.985273;26.6039 143.428;31.9156;22.3625;45.3228 1 3 1 25287 ACADL_32776 33.4878 33.4878 26.6039 26.6039 45.3228 45.3228 33.4878 26.6039 45.3228 3 246273;24890;25428 TRIB3_10079;ESR1_33192;CYP7A1_8430 45.727493333333335 23.3972 54.703652387332724 34.39255766666667 18.3088 43.7269779467982 65.90203333333334 31.9156 67.30915287390962 108.064;23.3972;5.72128 83.8836;18.3088;0.985273 143.428;31.9156;22.3625 0 Exp 2,2(0.5);Hill,1(0.25);Poly 2,1(0.25) 2.504910708938567 10.761677622795105 1.87713623046875 4.560328960418701 1.2737528461041063 2.162106215953827 -1.513429701403794 86.84856970140379 -2.7510016698705613 67.64178816987057 5.962829564081375 115.55162043591861 DOWN 0.25 0.75 0.0 GO:0009891 6 positive regulation of biosynthetic process 418 451 35 35 28 29 24 24 138 427 1958 0.18774 0.86613 0.39434 5.32 24825;293615;25106;83516;29441;303612;25513;81819;25591;25493;58954;24516;494344;24471;290556;294515;314322;24890;24330;25428;25146;25695;29184;25698 tf;sirt3;rgn;ppargc1a;por;polg2;pik3r1;pax8;parp1;nfkbia;klf6;jun;ier2;hspb1;gnl3;foxo3;fos;esr1;egr1;cyp7a1;cyp17a1;cebpd;cd36;ass1 TF_10003;SIRT3_9828;RGN_9699;PPARGC1A_33189;POR_9531;POLG2_9521;PIK3R1_32562;PAX8_9432;PARP1_9425;NFKBIA_9307;KLF6_8969;JUN_8938;IER2_32643;HSPB1_8847;GNL3_8735;FOXO3_8662;FOS_8657;ESR1_33192;EGR1_8533;CYP7A1_8430;CYP17A1_32365;CEBPD_8283;CD36_8243;ASS1_33159 32.35497766666672 25.100450000000002 1.28141E-12 28.15267264529321 35.96813843219456 26.923930353813713 22.158217841666723 19.645650000000003 1.28141E-12 19.78964285497952 25.3550321056881 19.330148407458076 59.000697083333385 43.57295 1.28142E-12 52.750301672806096 59.59442789984008 40.35785246069723 21.5 82.5382 45.1539;2.38018;77.4407;42.4094;12.4414;63.7758;18.7324;56.8931;26.9741;0.520151;18.9476;16.4324;49.6814;89.1011;87.6357;13.1992;1.28141E-12;23.3972;0.750017;5.72128;49.6922;0.306936;48.1296;26.8037 28.132;0.56209;58.7732;26.2988;8.48981;40.9553;11.6701;45.1162;21.799;0.160202;11.6941;10.5224;33.4626;60.3265;54.41;5.6804;1.28141E-12;18.3088;0.186019;0.985273;35.6654;0.0732342;37.5433;20.9825 61.5341;8.82917;89.8047;81.7305;79.2355;132.567;41.5978;81.5688;35.2797;2.88499;45.5481;39.929;89.4404;106.138;238.963;32.7581;1.28142E-12;31.9156;4.70178;22.3625;81.6409;1.73689;69.1421;36.7081 8 16 8 24825;293615;25106;81819;25591;290556;25146;29184 TF_10003;SIRT3_9828;RGN_9699;PAX8_9432;PARP1_9425;GNL3_8735;CYP17A1_32365;CD36_8243 49.287434999999995 48.9109 26.826979802879162 35.25014875 36.60435 18.739060228460485 83.34530874999999 75.35544999999999 68.45756579545808 45.1539;2.38018;77.4407;56.8931;26.9741;87.6357;49.6922;48.1296 28.132;0.56209;58.7732;45.1162;21.799;54.41;35.6654;37.5433 61.5341;8.82917;89.8047;81.5688;35.2797;238.963;81.6409;69.1421 16 83516;29441;303612;25513;25493;58954;24516;494344;24471;294515;314322;24890;24330;25428;25695;25698 PPARGC1A_33189;POR_9531;POLG2_9521;PIK3R1_32562;NFKBIA_9307;KLF6_8969;JUN_8938;IER2_32643;HSPB1_8847;FOXO3_8662;FOS_8657;ESR1_33192;EGR1_8533;CYP7A1_8430;CEBPD_8283;ASS1_33159 23.888749000000075 17.5824 25.496239224807923 15.61225238750008 11.09625 17.30633539663402 46.82839125000008 38.31855 40.068840680568115 42.4094;12.4414;63.7758;18.7324;0.520151;18.9476;16.4324;49.6814;89.1011;13.1992;1.28141E-12;23.3972;0.750017;5.72128;0.306936;26.8037 26.2988;8.48981;40.9553;11.6701;0.160202;11.6941;10.5224;33.4626;60.3265;5.6804;1.28141E-12;18.3088;0.186019;0.985273;0.0732342;20.9825 81.7305;79.2355;132.567;41.5978;2.88499;45.5481;39.929;89.4404;106.138;32.7581;1.28142E-12;31.9156;4.70178;22.3625;1.73689;36.7081 0 Exp 2,9(0.38);Exp 4,2(0.09);Hill,5(0.21);Linear,1(0.05);Poly 2,7(0.3) 1.9604613138695957 49.24103760719299 1.5209722518920898 4.560328960418701 0.767525040429178 1.8215704560279846 21.091562796825606 43.61839253650785 14.240711734519643 30.075723948813796 37.89618101354476 80.10521315312201 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0032024 8 positive regulation of insulin secretion 27 29 4 4 4 3 3 3 159 26 2359 0.8916 0.27947 0.42657 10.34 293615;100359982;24957 sirt3;mpc2;glul SIRT3_9828;MPC2_33219;GLUL_32832 25.231126666666665 26.4669 2.38018 22.258802949892285 24.36201227649243 22.696331534136032 19.152363333333337 21.0456 0.56209 17.719673263523607 18.426976535989716 18.08625872416525 37.79549 35.4303 8.82917 30.218416048484404 36.77492105327049 30.708533608413443 0.5 14.42354 1.5 36.6566 2.38018;46.8463;26.4669 0.56209;35.8494;21.0456 8.82917;69.127;35.4303 2 1 2 293615;100359982 SIRT3_9828;MPC2_33219 24.61324 24.61324 31.44229498505476 18.205745 18.205745 24.951896190831874 38.978085 38.978085 42.637004483833636 2.38018;46.8463 0.56209;35.8494 8.82917;69.127 1 24957 GLUL_32832 26.4669 26.4669 21.0456 21.0456 35.4303 35.4303 26.4669 21.0456 35.4303 0 Exp 2,1(0.34);Hill,1(0.34);Linear,1(0.34) 1.9044215388588033 5.805617928504944 1.5209722518920898 2.3622660636901855 0.4207935433654185 1.9223796129226685 0.04291995174673957 50.41933338158659 -0.8993345988158978 39.20406126548257 3.6001331454499024 71.9908468545501 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0002761 7 regulation of myeloid leukocyte differentiation 45 48 6 6 5 3 3 3 159 45 2340 0.63507 0.59835 1.0 6.25 25513;24516;314322 pik3r1;jun;fos PIK3R1_32562;JUN_8938;FOS_8657 11.721600000000427 16.4324 1.28141E-12 10.216135762605399 12.929147417434013 9.523585861186717 7.397500000000427 10.5224 1.28141E-12 6.432072644955939 8.164633113156805 5.995844358832839 27.17560000000043 39.929 1.28142E-12 23.54954670221839 30.036097087168717 21.96323384025318 1.5 17.5824 18.7324;16.4324;1.28141E-12 11.6701;10.5224;1.28141E-12 41.5978;39.929;1.28142E-12 0 3 0 3 25513;24516;314322 PIK3R1_32562;JUN_8938;FOS_8657 11.721600000000427 16.4324 10.216135762605399 7.397500000000427 10.5224 6.432072644955939 27.17560000000043 39.929 23.54954670221839 18.7324;16.4324;1.28141E-12 11.6701;10.5224;1.28141E-12 41.5978;39.929;1.28142E-12 0 Hill,1(0.34);Poly 2,2(0.67) 1.8449802871430698 5.548754096031189 1.6735800504684448 1.9785058498382568 0.15782134694327896 1.8966681957244873 0.16095408406916967 23.28224591593169 0.11892460889584644 14.676075391105009 0.5267792294742968 53.82442077052656 DOWN 0.0 1.0 0.0 GO:1901564 4 organonitrogen compound metabolic process 832 911 90 90 63 79 56 56 106 855 1530 0.40603 0.65832 0.79957 6.15 79426;312688;24856;246273;24825;360268;293615;293656;29676;192280;298490;29441;85253;24651;25513;25591;294103;100359982;54404;50693;306251;364070;65164;24464;25675;24443;81869;57298;29328;24957;25661;361969;304929;29496;171142;116663;25423;83842;497840;113936;291394;362866;81718;29184;25698;25028;25377;192272;170570;50559;24158;25287;170465;312382;25303;296925 zfp36;usp18;ttr;trib3;tf;sult1e1;sirt3;rgd1307603;psmb3;ppp1r3b;ppcs;por;plg;pklr;pik3r1;parp1;papss2;mpc2;itih4;itih3;itih1;iars2;htra1;hp;hmgcr;hdc;gstm7;gstm3l;gpx4;glul;fn1;fga;f5;erbb3;ehhadh;dusp6;ctsc;crot;cps1;cpb2;cndp2;chpt1;cdo1;cd36;ass1;ampd1;ambp;acot2;acot12;acot1;acadm;acadl;acaa2;abcg2;abcc2;aass ZFP36_10204;USP18_10138;TTR_10102;TRIB3_10079;TF_10003;SULT1E1_32446;SIRT3_9828;RGD1307603_9684;PSMB3_9589;PPP1R3B_9545;PPCS_9540;POR_9531;PLG_9501;PKLR_9489;PIK3R1_32562;PARP1_9425;PAPSS2_33237;MPC2_33219;ITIH4_32725;ITIH3_32422;ITIH1_33132;IARS2_8858;HTRA1_8856;HP_8823;HMGCR_8810;HDC_8788;GSTM7_8761;GSTM3_8760;GPX4_32827;GLUL_32832;FN1_8655;FGA_8632;F5_33079;ERBB3_8571;EHHADH_8534;DUSP6_8506;CTSC_32456;CROT_8384;CPS1_32421;CPB2_8369;CNDP2_8341;CHPT1_33298;CDO1_8275;CD36_8243;ASS1_33159;AMPD1_32743;AMBP_33085;ACOT2_7969;ACOT12_32718;ACOT1_7968;ACADM_7957;ACADL_32776;ACAA2_7955;ABCG2_32656;ABCC2_32541;AASS_7936 36.212147928571426 30.77205 0.348134 24.67149105933893 39.22066148566156 23.601800867030406 25.707985696428572 24.24965 0.118102 16.430242420783095 27.413207569069808 14.958635420689207 57.022653392857144 43.460300000000004 1.15962 39.627297626368986 62.14277460225467 39.253818239761316 44.5 56.67745 0.348134;108.883;46.6406;108.064;45.1539;50.1846;2.38018;34.7372;23.7888;36.1411;20.3353;12.4414;70.7857;23.0963;18.7324;26.9741;34.4443;46.8463;57.1163;27.1247;98.1741;24.7304;33.1323;64.9285;1.63089;24.5745;42.3152;73.0961;45.9204;26.4669;59.5777;28.5803;10.6089;60.9984;8.62809;62.3934;56.2386;7.4229;31.9826;25.8316;33.544;16.0559;22.9638;48.1296;26.8037;60.9045;17.2343;8.54905;30.3423;31.2018;11.7137;33.4878;26.5872;5.21654;46.2316;27.4644 0.118102;73.1414;28.5876;83.8836;28.132;36.5009;0.56209;26.1766;19.2724;27.0588;16.7643;8.48981;46.2356;17.4625;11.6701;21.799;25.719;35.8494;39.6402;21.5108;42.9071;19.8021;25.6145;41.6103;0.663137;21.0619;31.4035;51.4219;34.2198;21.0456;31.0499;22.529;2.59129;41.6036;7.31865;39.0875;38.2681;5.75707;24.4836;20.4374;26.3005;10.6021;18.5144;37.5433;20.9825;50.0633;14.1233;7.19676;24.0157;26.858;8.36151;26.6039;21.3695;2.73368;31.1788;21.7498 1.15962;138.144;63.7146;143.428;61.5341;80.9788;8.82917;50.9085;30.901;53.6244;25.6711;79.2355;150.579;32.9443;41.5978;35.2797;51.1014;69.127;101.869;36.4819;104.278;32.7087;46.6629;136.455;7.6286;29.28;64.5991;140.853;70.4292;35.4303;105.243;38.8511;37.5078;113.972;10.3909;133.304;102.888;10.316;45.5891;34.8042;46.311;29.905;30.0179;69.1421;36.7081;82.6625;21.9073;10.4125;41.1025;37.2719;18.9642;45.3228;35.0407;11.386;81.7848;37.0295 29 27 29 312688;24856;24825;360268;293615;29676;298490;25591;100359982;364070;24443;81869;57298;29328;29496;171142;83842;291394;362866;29184;25028;192272;170570;50559;24158;25287;170465;312382;296925 USP18_10138;TTR_10102;TF_10003;SULT1E1_32446;SIRT3_9828;PSMB3_9589;PPCS_9540;PARP1_9425;MPC2_33219;IARS2_8858;HDC_8788;GSTM7_8761;GSTM3_8760;GPX4_32827;ERBB3_8571;EHHADH_8534;CROT_8384;CNDP2_8341;CHPT1_33298;CD36_8243;AMPD1_32743;ACOT2_7969;ACOT12_32718;ACOT1_7968;ACADM_7957;ACADL_32776;ACAA2_7955;ABCG2_32656;AASS_7936 34.209295172413796 30.3423 23.136838774049366 25.39985034482759 24.0157 16.073244455456408 50.04410586206897 37.2719 35.6874836747793 108.883;46.6406;45.1539;50.1846;2.38018;23.7888;20.3353;26.9741;46.8463;24.7304;24.5745;42.3152;73.0961;45.9204;60.9984;8.62809;7.4229;33.544;16.0559;48.1296;60.9045;8.54905;30.3423;31.2018;11.7137;33.4878;26.5872;5.21654;27.4644 73.1414;28.5876;28.132;36.5009;0.56209;19.2724;16.7643;21.799;35.8494;19.8021;21.0619;31.4035;51.4219;34.2198;41.6036;7.31865;5.75707;26.3005;10.6021;37.5433;50.0633;7.19676;24.0157;26.858;8.36151;26.6039;21.3695;2.73368;21.7498 138.144;63.7146;61.5341;80.9788;8.82917;30.901;25.6711;35.2797;69.127;32.7087;29.28;64.5991;140.853;70.4292;113.972;10.3909;10.316;46.311;29.905;69.1421;82.6625;10.4125;41.1025;37.2719;18.9642;45.3228;35.0407;11.386;37.0295 27 79426;246273;293656;192280;29441;85253;24651;25513;294103;54404;50693;306251;65164;24464;25675;24957;25661;361969;304929;116663;25423;497840;113936;81718;25698;25377;25303 ZFP36_10204;TRIB3_10079;RGD1307603_9684;PPP1R3B_9545;POR_9531;PLG_9501;PKLR_9489;PIK3R1_32562;PAPSS2_33237;ITIH4_32725;ITIH3_32422;ITIH1_33132;HTRA1_8856;HP_8823;HMGCR_8810;GLUL_32832;FN1_8655;FGA_8632;F5_33079;DUSP6_8506;CTSC_32456;CPS1_32421;CPB2_8369;CDO1_8275;ASS1_33159;AMBP_33085;ABCC2_32541 38.36336014814815 31.9826 26.492004482585045 26.038945888888886 24.4836 17.105913816844748 64.51813037037037 46.6629 42.86733798926616 0.348134;108.064;34.7372;36.1411;12.4414;70.7857;23.0963;18.7324;34.4443;57.1163;27.1247;98.1741;33.1323;64.9285;1.63089;26.4669;59.5777;28.5803;10.6089;62.3934;56.2386;31.9826;25.8316;22.9638;26.8037;17.2343;46.2316 0.118102;83.8836;26.1766;27.0588;8.48981;46.2356;17.4625;11.6701;25.719;39.6402;21.5108;42.9071;25.6145;41.6103;0.663137;21.0456;31.0499;22.529;2.59129;39.0875;38.2681;24.4836;20.4374;18.5144;20.9825;14.1233;31.1788 1.15962;143.428;50.9085;53.6244;79.2355;150.579;32.9443;41.5978;51.1014;101.869;36.4819;104.278;46.6629;136.455;7.6286;35.4303;105.243;38.8511;37.5078;133.304;102.888;45.5891;34.8042;30.0179;36.7081;21.9073;81.7848 0 Exp 2,28(0.5);Exp 3,1(0.02);Exp 4,2(0.04);Hill,3(0.06);Linear,12(0.22);Poly 2,8(0.15);Power,2(0.04) 2.2916917095885427 505.17551243305206 1.5074360370635986 344.14306640625 45.84669577314215 1.7925106287002563 29.75028925502825 42.67400660211463 21.404642042013894 30.011329350843244 46.643629431145634 67.40167735456866 CONFLICT 0.5178571428571429 0.48214285714285715 0.0 GO:0043603 5 cellular amide metabolic process 114 134 28 28 17 25 15 15 147 119 2266 0.99059 0.020604 0.027212 11.19 293656;298490;100359982;364070;81869;57298;29328;497840;25698;192272;170570;50559;170465;25303;296925 rgd1307603;ppcs;mpc2;iars2;gstm7;gstm3l;gpx4;cps1;ass1;acot2;acot12;acot1;acaa2;abcc2;aass RGD1307603_9684;PPCS_9540;MPC2_33219;IARS2_8858;GSTM7_8761;GSTM3_8760;GPX4_32827;CPS1_32421;ASS1_33159;ACOT2_7969;ACOT12_32718;ACOT1_7968;ACAA2_7955;ABCC2_32541;AASS_7936 34.476236666666665 31.2018 8.54905 14.992030726814106 34.604021592015926 12.919053496882578 26.231484000000002 24.4836 7.19676 10.053507056934906 26.667090324247265 8.486368074852058 51.94904666666668 41.1025 10.4125 31.043842965896435 50.88368296749058 27.781650219241108 5.5 28.903350000000003 12.5 46.53895 34.7372;20.3353;46.8463;24.7304;42.3152;73.0961;45.9204;31.9826;26.8037;8.54905;30.3423;31.2018;26.5872;46.2316;27.4644 26.1766;16.7643;35.8494;19.8021;31.4035;51.4219;34.2198;24.4836;20.9825;7.19676;24.0157;26.858;21.3695;31.1788;21.7498 50.9085;25.6711;69.127;32.7087;64.5991;140.853;70.4292;45.5891;36.7081;10.4125;41.1025;37.2719;35.0407;81.7848;37.0295 11 4 11 298490;100359982;364070;81869;57298;29328;192272;170570;50559;170465;296925 PPCS_9540;MPC2_33219;IARS2_8858;GSTM7_8761;GSTM3_8760;GPX4_32827;ACOT2_7969;ACOT12_32718;ACOT1_7968;ACAA2_7955;AASS_7936 34.30804090909091 30.3423 17.155173839877257 26.422796363636362 24.0157 11.659903833314644 51.295018181818186 37.2719 35.10468206407282 20.3353;46.8463;24.7304;42.3152;73.0961;45.9204;8.54905;30.3423;31.2018;26.5872;27.4644 16.7643;35.8494;19.8021;31.4035;51.4219;34.2198;7.19676;24.0157;26.858;21.3695;21.7498 25.6711;69.127;32.7087;64.5991;140.853;70.4292;10.4125;41.1025;37.2719;35.0407;37.0295 4 293656;497840;25698;25303 RGD1307603_9684;CPS1_32421;ASS1_33159;ABCC2_32541 34.938775 33.3599 8.21557352121567 25.705374999999997 25.3301 4.241804515671003 53.747625 48.2488 19.58784278702398 34.7372;31.9826;26.8037;46.2316 26.1766;24.4836;20.9825;31.1788 50.9085;45.5891;36.7081;81.7848 0 Exp 2,11(0.74);Linear,4(0.27) 3.109415853449771 381.7145618200302 1.547789216041565 344.14306640625 88.20158342189558 1.9082608222961426 26.88922231677797 42.06325101655538 21.14370745407495 31.319260545925054 36.238694523598504 67.65939880973485 UP 0.7333333333333333 0.26666666666666666 0.0 GO:0014910 7 regulation of smooth muscle cell migration 45 50 4 4 4 3 3 3 159 47 2338 0.6054 0.62652 1.0 6.0 83516;361969;24330 ppargc1a;fga;egr1 PPARGC1A_33189;FGA_8632;EGR1_8533 23.913239 28.5803 0.750017 21.21820307586066 23.835481783797928 19.779267490496302 16.337939666666667 22.529 0.186019 14.114398815632226 16.794305642327085 13.477315126827847 41.76112666666667 38.8511 4.70178 38.59672418237244 39.83252614213682 35.34436172293908 1.5 35.49485 42.4094;28.5803;0.750017 26.2988;22.529;0.186019 81.7305;38.8511;4.70178 0 3 0 3 83516;361969;24330 PPARGC1A_33189;FGA_8632;EGR1_8533 23.913239 28.5803 21.21820307586066 16.337939666666667 22.529 14.114398815632226 41.76112666666667 38.8511 38.59672418237244 42.4094;28.5803;0.750017 26.2988;22.529;0.186019 81.7305;38.8511;4.70178 0 Exp 2,1(0.34);Hill,1(0.34);Linear,1(0.34) 2.252711565935136 7.517804503440857 1.541895866394043 4.21828556060791 1.4868568573473329 1.7576230764389038 -0.0974181048338707 47.923896104833865 0.3659938335828663 32.309885499750465 -1.915178362533048 85.4374316958664 DOWN 0.0 1.0 0.0 GO:0045935 7 positive regulation of nucleobase-containing compound metabolic process 358 387 27 27 21 22 18 18 144 369 2016 0.079582 0.95082 0.14267 4.65 79426;24825;293615;83516;303612;25513;81819;25591;25493;58954;24516;494344;290556;294515;314322;24890;24330;25695 zfp36;tf;sirt3;ppargc1a;polg2;pik3r1;pax8;parp1;nfkbia;klf6;jun;ier2;gnl3;foxo3;fos;esr1;egr1;cebpd ZFP36_10204;TF_10003;SIRT3_9828;PPARGC1A_33189;POLG2_9521;PIK3R1_32562;PAX8_9432;PARP1_9425;NFKBIA_9307;KLF6_8969;JUN_8938;IER2_32643;GNL3_8735;FOXO3_8662;FOS_8657;ESR1_33192;EGR1_8533;CEBPD_8283 25.974312111111182 18.84 1.28141E-12 26.101386693620025 28.44856380966814 23.688074665317522 17.174963733333403 11.6821 1.28141E-12 17.477959929098603 19.466213023849228 16.716884132697846 51.7858083333334 37.60435 1.28142E-12 59.593363809721254 50.41233125873591 44.8426558041585 0.348134;45.1539;2.38018;42.4094;63.7758;18.7324;56.8931;26.9741;0.520151;18.9476;16.4324;49.6814;87.6357;13.1992;1.28141E-12;23.3972;0.750017;0.306936 0.118102;28.132;0.56209;26.2988;40.9553;11.6701;45.1162;21.799;0.160202;11.6941;10.5224;33.4626;54.41;5.6804;1.28141E-12;18.3088;0.186019;0.0732342 1.15962;61.5341;8.82917;81.7305;132.567;41.5978;81.5688;35.2797;2.88499;45.5481;39.929;89.4404;238.963;32.7581;1.28142E-12;31.9156;4.70178;1.73689 5 13 5 24825;293615;81819;25591;290556 TF_10003;SIRT3_9828;PAX8_9432;PARP1_9425;GNL3_8735 43.807396 45.1539 31.99040103471791 30.003858 28.132 20.98620915141226 85.23495399999999 61.5341 90.19541912331013 45.1539;2.38018;56.8931;26.9741;87.6357 28.132;0.56209;45.1162;21.799;54.41 61.5341;8.82917;81.5688;35.2797;238.963 13 79426;83516;303612;25513;25493;58954;24516;494344;294515;314322;24890;24330;25695 ZFP36_10204;PPARGC1A_33189;POLG2_9521;PIK3R1_32562;NFKBIA_9307;KLF6_8969;JUN_8938;IER2_32643;FOXO3_8662;FOS_8657;ESR1_33192;EGR1_8533;CEBPD_8283 19.115433692307793 16.4324 20.989259902562736 12.24077363076933 10.5224 13.820446391467208 38.92075230769241 32.7581 40.91308496389769 0.348134;42.4094;63.7758;18.7324;0.520151;18.9476;16.4324;49.6814;13.1992;1.28141E-12;23.3972;0.750017;0.306936 0.118102;26.2988;40.9553;11.6701;0.160202;11.6941;10.5224;33.4626;5.6804;1.28141E-12;18.3088;0.186019;0.0732342 1.15962;81.7305;132.567;41.5978;2.88499;45.5481;39.929;89.4404;32.7581;1.28142E-12;31.9156;4.70178;1.73689 0 Exp 2,7(0.39);Exp 4,2(0.12);Hill,5(0.28);Poly 2,4(0.23) 1.871806485626786 34.758607149124146 1.5209722518920898 4.21828556060791 0.6104138280449056 1.7867289185523987 13.916086658549572 38.03253756367279 9.100558195047451 25.249369271619347 24.25507884646709 79.31653782019973 DOWN 0.2777777777777778 0.7222222222222222 0.0 GO:0034614 6 cellular response to reactive oxygen species 66 70 7 7 7 7 7 7 155 63 2322 0.92682 0.1535 0.20899 10.0 25591;24314;58954;24516;24471;314322;24360 parp1;nqo1;klf6;jun;hspb1;fos;fabp1 PARP1_9425;NQO1_33055;KLF6_8969;JUN_8938;HSPB1_8847;FOS_8657;FABP1_33091 38.93992857142876 26.9741 1.28141E-12 35.22375657751973 40.07769035703795 32.64401958183744 27.359257142857327 21.799 1.28141E-12 24.178149907016845 28.521613869924643 21.890619122697515 67.2767857142859 45.5481 1.28142E-12 65.25955673037271 57.905474171103876 44.14684782904605 2.5 22.96085 6.0 89.1011 26.9741;87.2765;18.9476;16.4324;89.1011;1.28141E-12;33.8478 21.799;60.6992;11.6941;10.5224;60.3265;1.28141E-12;26.4736 35.2797;197.117;45.5481;39.929;106.138;1.28142E-12;46.9257 3 4 3 25591;24314;24360 PARP1_9425;NQO1_33055;FABP1_33091 49.36613333333333 33.8478 33.01073860917585 36.323933333333336 26.4736 21.23860141566137 93.10746666666667 46.9257 90.26291928119393 26.9741;87.2765;33.8478 21.799;60.6992;26.4736 35.2797;197.117;46.9257 4 58954;24516;24471;314322 KLF6_8969;JUN_8938;HSPB1_8847;FOS_8657 31.120275000000323 17.69 39.5565218913705 20.63575000000032 11.10825 26.977909275120805 47.90377500000032 42.738550000000004 43.79932595222358 18.9476;16.4324;89.1011;1.28141E-12 11.6941;10.5224;60.3265;1.28141E-12 45.5481;39.929;106.138;1.28142E-12 0 Exp 2,3(0.43);Hill,1(0.15);Poly 2,3(0.43) 1.766215476555102 12.407277584075928 1.5740432739257812 1.9785058498382568 0.15974152770600403 1.8086696863174438 12.845804530662772 65.03405261219474 9.447833034487637 45.27068125122702 18.931829536200176 115.62174189237163 CONFLICT 0.42857142857142855 0.5714285714285714 0.0 GO:0007584 4 response to nutrient 144 154 24 24 18 20 15 15 147 139 2246 0.96784 0.060638 0.086688 9.74 24522;29573;29441;24651;25513;24314;24539;63868;24464;25675;304929;29184;25698;24158;312382 zfp354a;slc37a4;por;pklr;pik3r1;nqo1;lpl;hspd1;hp;hmgcr;f5;cd36;ass1;acadm;abcg2 ZFP354A_10203;SLC37A4_9871;POR_9531;PKLR_9489;PIK3R1_32562;NQO1_33055;LPL_32544;HSPD1_8849;HP_8823;HMGCR_8810;F5_33079;CD36_8243;ASS1_33159;ACADM_7957;ABCG2_32656 31.172790466666665 23.0963 0.834827 27.360682255934684 32.53254971304286 25.946050052077222 20.638965133333333 17.4625 0.27095 18.9907338865032 21.64368903489414 17.71964078425344 65.96842466666666 41.5978 2.99857 58.325556866253365 66.11157815791955 53.50529408508626 6.5 20.91435 0.834827;39.7166;12.4414;23.0963;18.7324;87.2765;74.2041;42.2579;64.9285;1.63089;10.6089;48.1296;26.8037;11.7137;5.21654 0.27095;22.6911;8.48981;17.4625;11.6701;60.6992;49.8682;23.9469;41.6103;0.663137;2.59129;37.5433;20.9825;8.36151;2.73368 2.99857;60.0334;79.2355;32.9443;41.5978;197.117;155.425;102.383;136.455;7.6286;37.5078;69.1421;36.7081;18.9642;11.386 6 9 6 24314;24539;63868;29184;24158;312382 NQO1_33055;LPL_32544;HSPD1_8849;CD36_8243;ACADM_7957;ABCG2_32656 44.79972333333333 45.19375 32.70460582374396 30.525465 30.7451 22.98150309011641 92.40288333333332 85.76255 74.20845744680095 87.2765;74.2041;42.2579;48.1296;11.7137;5.21654 60.6992;49.8682;23.9469;37.5433;8.36151;2.73368 197.117;155.425;102.383;69.1421;18.9642;11.386 9 24522;29573;29441;24651;25513;24464;25675;304929;25698 ZFP354A_10203;SLC37A4_9871;POR_9531;PKLR_9489;PIK3R1_32562;HP_8823;HMGCR_8810;F5_33079;ASS1_33159 22.088168555555555 18.7324 20.234895185002593 14.047965222222224 11.6701 13.373927116457713 48.345452222222235 37.5078 40.47206805232213 0.834827;39.7166;12.4414;23.0963;18.7324;64.9285;1.63089;10.6089;26.8037 0.27095;22.6911;8.48981;17.4625;11.6701;41.6103;0.663137;2.59129;20.9825 2.99857;60.0334;79.2355;32.9443;41.5978;136.455;7.6286;37.5078;36.7081 0 Exp 2,6(0.4);Exp 3,1(0.07);Exp 4,2(0.14);Hill,2(0.14);Poly 2,4(0.27) 1.9848408269626674 31.217352747917175 1.5074360370635986 4.591650485992432 0.7878463491893742 1.8814297914505005 17.326374815500586 45.01920611783276 11.02832777957466 30.249602487092012 36.45162037423367 95.48522895909966 DOWN 0.4 0.6 0.0 GO:0006325 5 chromatin organization 88 101 3 3 3 2 2 2 160 99 2286 0.038081 0.99069 0.090843 1.98 293615;29328 sirt3;gpx4 SIRT3_9828;GPX4_32827 24.150290000000002 24.150290000000002 2.38018 30.787584816354137 21.56933443021347 30.570454944566585 17.390945 17.390945 0.56209 23.799594980210273 15.39579995730706 23.63174800431161 39.629185 39.629185 8.82917 43.55779893429476 35.97768896880131 43.250606949136916 2.38018;45.9204 0.56209;34.2198 8.82917;70.4292 2 0 2 293615;29328 SIRT3_9828;GPX4_32827 24.150290000000002 24.150290000000002 30.787584816354137 17.390945 17.390945 23.799594980210273 39.629185 39.629185 43.55779893429476 2.38018;45.9204 0.56209;34.2198 8.82917;70.4292 0 0 Exp 2,1(0.5);Hill,1(0.5) 1.5343221465445356 3.068761467933655 1.5209722518920898 1.547789216041565 0.01896245720093038 1.5343807339668274 -18.519125599999995 66.81970559999999 -15.593610799999993 50.3755008 -20.738844399999984 99.99721439999999 UP 1.0 0.0 0.0 GO:0001933 9 negative regulation of protein phosphorylation 121 130 16 16 14 15 13 13 149 117 2268 0.96641 0.065747 0.094051 10.0 246273;293615;25106;83516;24516;24471;25675;299626;25112;116663;140942;114851;25373 trib3;sirt3;rgn;ppargc1a;jun;hspb1;hmgcr;gadd45b;gadd45a;dusp6;ddit4;cdkn1a;ahsg TRIB3_10079;SIRT3_9828;RGN_9699;PPARGC1A_33189;JUN_8938;HSPB1_8847;HMGCR_8810;GADD45B_8679;GADD45A_8678;DUSP6_8506;DDIT4_8450;CDKN1A_8271;AHSG_8003 55.02552615384615 62.3934 1.63089 42.802817435815 55.98495442720435 42.22182863121828 37.562959769230766 39.0875 0.56209 31.430561889330388 40.45725982667469 33.70516222194653 85.81839 89.8047 7.6286 68.62259203018931 81.06812314952315 57.220177408815424 5.5 52.401399999999995 12.0 108.064 108.064;2.38018;77.4407;42.4094;16.4324;89.1011;1.63089;106.367;102.919;62.3934;87.5421;6.24967;12.402 83.8836;0.56209;58.7732;26.2988;10.5224;60.3265;0.663137;52.7132;89.5012;39.0875;53.2453;2.44025;10.3013 143.428;8.82917;89.8047;81.7305;39.929;106.138;7.6286;109.434;115.437;133.304;245.492;19.0606;15.4235 3 10 3 293615;25106;299626 SIRT3_9828;RGN_9699;GADD45B_8679 62.06262666666667 77.4407 53.671952992341666 37.34949666666667 52.7132 32.00259156605968 69.35595666666667 89.8047 53.328662863104235 2.38018;77.4407;106.367 0.56209;58.7732;52.7132 8.82917;89.8047;109.434 10 246273;83516;24516;24471;25675;25112;116663;140942;114851;25373 TRIB3_10079;PPARGC1A_33189;JUN_8938;HSPB1_8847;HMGCR_8810;GADD45A_8678;DUSP6_8506;DDIT4_8450;CDKN1A_8271;AHSG_8003 52.914395999999996 52.401399999999995 42.20385189523297 37.6269987 32.69315 33.00850598276022 90.75712 93.93425 74.35940006622192 108.064;42.4094;16.4324;89.1011;1.63089;102.919;62.3934;87.5421;6.24967;12.402 83.8836;26.2988;10.5224;60.3265;0.663137;89.5012;39.0875;53.2453;2.44025;10.3013 143.428;81.7305;39.929;106.138;7.6286;115.437;133.304;245.492;19.0606;15.4235 0 Exp 2,3(0.24);Exp 4,2(0.16);Hill,1(0.08);Linear,1(0.08);Poly 2,5(0.39);Power,1(0.08) 1.7938599815312979 23.89633822441101 1.5209722518920898 3.431420087814331 0.4998278720016938 1.6973176002502441 31.75764954781969 78.2934027598726 20.477111698699616 54.64880783976193 48.51472404066277 123.12205595933727 DOWN 0.23076923076923078 0.7692307692307693 0.0 GO:0042035 6 regulation of cytokine biosynthetic process 40 43 4 4 3 4 3 3 159 40 2345 0.70906 0.52221 0.75199 6.98 79426;24471;24330 zfp36;hspb1;egr1 ZFP36_10204;HSPB1_8847;EGR1_8533 30.066417 0.750017 0.348134 51.125930066545386 40.013250957872394 53.84180122076927 20.210207 0.186019 0.118102 34.74174544012015 26.942891363197845 36.61651524277759 37.333133333333336 4.70178 1.15962 59.61307727445157 49.324119351685106 62.33216995124905 1.5 44.9255585 0.348134;89.1011;0.750017 0.118102;60.3265;0.186019 1.15962;106.138;4.70178 0 3 0 3 79426;24471;24330 ZFP36_10204;HSPB1_8847;EGR1_8533 30.066417 0.750017 51.125930066545386 20.210207 0.186019 34.74174544012015 37.333133333333336 4.70178 59.61307727445157 0.348134;89.1011;0.750017 0.118102;60.3265;0.186019 1.15962;106.138;4.70178 0 Hill,2(0.67);Poly 2,1(0.34) 2.403057369764497 7.853779673576355 1.6973176002502441 4.21828556060791 1.3911739492920872 1.9381765127182007 -27.78801919352032 87.92085319352032 -19.103778920662805 59.52419292066281 -30.125414041454746 104.79168070812142 DOWN 0.0 1.0 0.0 GO:0006662 5 glycerol ether metabolic process 2 2 1 1 1 1 1 1 161 1 2384 0.99598 0.12319 0.12319 50.0 362732 agmo AGMO_33265 31.5332 31.5332 31.5332 31.5332 24.5474 24.5474 24.5474 24.5474 43.8459 43.8459 43.8459 43.8459 0.0 31.5332 0.0 31.5332 31.5332 24.5474 43.8459 1 0 1 362732 AGMO_33265 31.5332 31.5332 24.5474 24.5474 43.8459 43.8459 31.5332 24.5474 43.8459 0 0 Linear,1(1) 2.42618465423584 2.42618465423584 2.42618465423584 2.42618465423584 0.0 2.42618465423584 31.5332 31.5332 24.5474 24.5474 43.8459 43.8459 UP 1.0 0.0 0.0 GO:0046485 5 ether lipid metabolic process 2 2 1 1 1 1 1 1 161 1 2384 0.99598 0.12319 0.12319 50.0 362732 agmo AGMO_33265 31.5332 31.5332 31.5332 31.5332 24.5474 24.5474 24.5474 24.5474 43.8459 43.8459 43.8459 43.8459 0.0 31.5332 0.0 31.5332 31.5332 24.5474 43.8459 1 0 1 362732 AGMO_33265 31.5332 31.5332 24.5474 24.5474 43.8459 43.8459 31.5332 24.5474 43.8459 0 0 Linear,1(1) 2.42618465423584 2.42618465423584 2.42618465423584 2.42618465423584 0.0 2.42618465423584 31.5332 31.5332 24.5474 24.5474 43.8459 43.8459 UP 1.0 0.0 0.0 GO:0030534 3 adult behavior 31 31 2 2 2 2 2 2 160 29 2356 0.68484 0.59663 1.0 6.45 29482;25591 slc1a2;parp1 SLC1A2_33059;PARP1_9425 20.1488 20.1488 13.3235 9.652431827265081 21.417746709618044 9.484144066614494 15.45426 15.45426 9.10952 8.972817357731072 16.633861914404054 8.816378507202854 29.978499999999997 29.978499999999997 24.6773 7.4970289368522645 30.964088955361255 7.366320092294356 0.5 20.1488 13.3235;26.9741 9.10952;21.799 24.6773;35.2797 1 1 1 25591 PARP1_9425 26.9741 26.9741 21.799 21.799 35.2797 35.2797 26.9741 21.799 35.2797 1 29482 SLC1A2_33059 13.3235 13.3235 9.10952 9.10952 24.6773 24.6773 13.3235 9.10952 24.6773 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.7119048478393357 3.428986668586731 1.620316982269287 1.8086696863174438 0.1331854742872745 1.7144933342933655 6.771212 33.526388000000004 3.018569600000001 27.889950399999996 19.588147999999997 40.368852 CONFLICT 0.5 0.5 0.0 GO:0001889 6 liver development 91 101 20 20 14 15 10 10 152 91 2294 0.94724 0.10471 0.14279 9.9 25106;25493;24516;24464;361969;25315;497840;113936;25698;24158 rgn;nfkbia;jun;hp;fga;ephx1;cps1;cpb2;ass1;acadm RGN_9699;NFKBIA_9307;JUN_8938;HP_8823;FGA_8632;EPHX1_8567;CPS1_32421;CPB2_8369;ASS1_33159;ACADM_7957 29.670835099999998 26.31765 0.520151 24.031786707351863 33.9773743581044 23.754518848824468 21.4864462 20.70995 0.160202 17.523666127993437 24.32501281106676 17.027118862735197 46.767439 37.7796 2.88499 38.70505215388251 54.75738174767161 41.744659057734715 4.5 26.31765 77.4407;0.520151;16.4324;64.9285;28.5803;12.4747;31.9826;25.8316;26.8037;11.7137 58.7732;0.160202;10.5224;41.6103;22.529;7.00435;24.4836;20.4374;20.9825;8.36151 89.8047;2.88499;39.929;136.455;38.8511;23.684;45.5891;34.8042;36.7081;18.9642 3 7 3 25106;25315;24158 RGN_9699;EPHX1_8567;ACADM_7957 33.87636666666667 12.4747 37.72973806340741 24.71302 8.36151 29.50478549389404 44.15096666666667 23.684 39.607659025286175 77.4407;12.4747;11.7137 58.7732;7.00435;8.36151 89.8047;23.684;18.9642 7 25493;24516;24464;361969;497840;113936;25698 NFKBIA_9307;JUN_8938;HP_8823;FGA_8632;CPS1_32421;CPB2_8369;ASS1_33159 27.86846442857143 26.8037 19.471669227054573 20.10362885714286 20.9825 12.767324928116137 47.88878428571429 38.8511 41.464556278071946 0.520151;16.4324;64.9285;28.5803;31.9826;25.8316;26.8037 0.160202;10.5224;41.6103;22.529;24.4836;20.4374;20.9825 2.88499;39.929;136.455;38.8511;45.5891;34.8042;36.7081 0 Exp 2,4(0.4);Exp 4,1(0.1);Hill,1(0.1);Linear,1(0.1);Poly 2,3(0.3) 1.7982029781384523 18.13788068294525 1.541895866394043 2.4453113079071045 0.26351999781521235 1.7731810212135315 14.775779381236326 44.565890818763684 10.625165407522621 32.347726992477384 22.777799134672566 70.75707886532744 DOWN 0.3 0.7 0.0 GO:0071348 7 cellular response to interleukin-11 1 1 1 1 1 1 1 1 161 0 2385 1.0 0.063604 0.063604 100.0 24471 hspb1 HSPB1_8847 89.1011 89.1011 89.1011 89.1011 60.3265 60.3265 60.3265 60.32650000000001 106.138 106.138 106.138 106.138 0.0 89.1011 0.0 89.1011 89.1011 60.3265 106.138 0 1 0 1 24471 HSPB1_8847 89.1011 89.1011 60.3265 60.3265 106.138 106.138 89.1011 60.3265 106.138 0 Poly 2,1(1) 1.6973176002502441 1.6973176002502441 1.6973176002502441 1.6973176002502441 0.0 1.6973176002502441 89.1011 89.1011 60.3265 60.3265 106.138 106.138 DOWN 0.0 1.0 0.0 GO:1903545 7 cellular response to butyrate 1 1 1 1 1 1 1 1 161 0 2385 1.0 0.063604 0.063604 100.0 24471 hspb1 HSPB1_8847 89.1011 89.1011 89.1011 89.1011 60.3265 60.3265 60.3265 60.32650000000001 106.138 106.138 106.138 106.138 0.0 89.1011 0.0 89.1011 89.1011 60.3265 106.138 0 1 0 1 24471 HSPB1_8847 89.1011 89.1011 60.3265 60.3265 106.138 106.138 89.1011 60.3265 106.138 0 Poly 2,1(1) 1.6973176002502441 1.6973176002502441 1.6973176002502441 1.6973176002502441 0.0 1.6973176002502441 89.1011 89.1011 60.3265 60.3265 106.138 106.138 DOWN 0.0 1.0 0.0 GO:0055082 5 cellular chemical homeostasis 190 202 26 26 21 21 17 17 145 185 2200 0.91463 0.13726 0.22738 8.42 24825;29573;25106;83516;25513;24567;288001;81678;81869;294515;25661;24890;25428;113936;29184;155423;25303 tf;slc37a4;rgn;ppargc1a;pik3r1;mt1;kng1;itpr2;gstm7;foxo3;fn1;esr1;cyp7a1;cpb2;cd36;anxa7;abcc2 TF_10003;SLC37A4_9871;RGN_9699;PPARGC1A_33189;PIK3R1_32562;MT1A_9255;KNG1L1_34113;ITPR2_8931;GSTM7_8761;FOXO3_8662;FN1_8655;ESR1_33192;CYP7A1_8430;CPB2_8369;CD36_8243;ANXA7_8051;ABCC2_32541 38.917910588235294 39.7166 5.72128 24.94051445264624 46.853907000012796 22.326069245136292 24.780029588235294 24.7342 0.985273 14.295834046909757 29.45727174756002 12.20368736051537 57.9964 60.0334 22.3625 28.027532171910885 69.11819166762604 25.376726635189584 9.5 42.3623 45.1539;39.7166;77.4407;42.4094;18.7324;12.9315;24.3655;31.8111;42.3152;13.1992;59.5777;23.3972;5.72128;25.8316;48.1296;104.64;46.2316 28.132;22.6911;58.7732;26.2988;11.6701;8.91033;19.538;24.7342;31.4035;5.6804;31.0499;18.3088;0.985273;20.4374;37.5433;43.9254;31.1788 61.5341;60.0334;89.8047;81.7305;41.5978;23.4636;32.1467;44.3296;64.5991;32.7581;105.243;31.9156;22.3625;34.8042;69.1421;108.689;81.7848 5 12 5 24825;25106;81869;29184;155423 TF_10003;RGN_9699;GSTM7_8761;CD36_8243;ANXA7_8051 63.53588 48.1296 26.965072835188135 39.95548 37.5433 12.130710040925067 78.7538 69.1421 20.046801284244825 45.1539;77.4407;42.3152;48.1296;104.64 28.132;58.7732;31.4035;37.5433;43.9254 61.5341;89.8047;64.5991;69.1421;108.689 12 29573;83516;25513;24567;288001;81678;294515;25661;24890;25428;113936;25303 SLC37A4_9871;PPARGC1A_33189;PIK3R1_32562;MT1A_9255;KNG1L1_34113;ITPR2_8931;FOXO3_8662;FN1_8655;ESR1_33192;CYP7A1_8430;CPB2_8369;ABCC2_32541 28.66042333333333 25.098550000000003 15.81481738855819 18.45692525 19.9877 9.770392080596352 49.347483333333344 38.201 26.8144984520021 39.7166;42.4094;18.7324;12.9315;24.3655;31.8111;13.1992;59.5777;23.3972;5.72128;25.8316;46.2316 22.6911;26.2988;11.6701;8.91033;19.538;24.7342;5.6804;31.0499;18.3088;0.985273;20.4374;31.1788 60.0334;81.7305;41.5978;23.4636;32.1467;44.3296;32.7581;105.243;31.9156;22.3625;34.8042;81.7848 0 Exp 2,5(0.3);Exp 3,1(0.06);Exp 4,1(0.06);Hill,1(0.06);Linear,3(0.18);Poly 2,5(0.3);Power,1(0.06) 1.9998571755796548 35.3540233373642 1.5461770296096802 4.560328960418701 0.7171228093176333 1.8344712257385254 27.061942595694802 50.773878580775786 17.98422145810872 31.575837718361875 44.67295693426094 71.31984306573906 DOWN 0.29411764705882354 0.7058823529411765 0.0 GO:0097009 5 energy homeostasis 9 10 2 2 2 2 2 2 160 8 2377 0.97825 0.12934 0.12934 20.0 83516;29184 ppargc1a;cd36 PPARGC1A_33189;CD36_8243 45.2695 45.2695 42.4094 4.04479220974334 45.93989791955617 3.9321085029422265 31.92105 31.92105 26.2988 7.951062201052134 33.2388866851595 7.729553872475148 75.4363 75.4363 69.1421 8.901343004288865 73.96096047156726 8.65336084025677 0.0 42.4094 0.0 42.4094 42.4094;48.1296 26.2988;37.5433 81.7305;69.1421 1 1 1 29184 CD36_8243 48.1296 48.1296 37.5433 37.5433 69.1421 69.1421 48.1296 37.5433 69.1421 1 83516 PPARGC1A_33189 42.4094 42.4094 26.2988 26.2988 81.7305 81.7305 42.4094 26.2988 81.7305 0 Exp 2,2(1) 2.1664255746120813 4.4279338121414185 1.7576230764389038 2.6703107357025146 0.6453676329705763 2.2139669060707092 39.663703999999996 50.875296000000006 20.90144 42.94066 63.099667999999994 87.77293200000001 CONFLICT 0.5 0.5 0.0 GO:0006082 4 organic acid metabolic process 306 341 88 88 61 79 54 54 108 287 2098 1.0 1.07E-11 1.07E-11 15.84 286954;360268;29573;65192;29500;246074;25106;501907;83516;29441;24651;294103;100359982;24552;24539;54404;50693;306251;364070;24443;171155;113965;85255;81869;29328;24957;25256;295143;65030;25315;171142;291075;29740;25428;65210;24894;25146;83842;497840;81718;29184;25698;25284;65183;50681;192272;170570;50559;24158;25287;170465;312382;25303;296925 ugt2b1;sult1e1;slc37a4;slc27a2;slc10a2;scd;rgn;rgd1559459;ppargc1a;por;pklr;papss2;mpc2;me1;lpl;itih4;itih3;itih1;iars2;hdc;hadhb;hadh;hacl1;gstm7;gpx4;glul;fmo1;etfdh;ephx2;ephx1;ehhadh;eci2;eci1;cyp7a1;cyp2j4;cyp2a1;cyp17a1;crot;cps1;cdo1;cd36;ass1;amacr;aldh3a2;acox1;acot2;acot12;acot1;acadm;acadl;acaa2;abcg2;abcc2;aass UGT2B10_33303,UGT2B1_33224;SULT1E1_32446;SLC37A4_9871;SLC27A2_9860;SLC10A2_9833;SCD1_9787;RGN_9699;RGD1559459_9690;PPARGC1A_33189;POR_9531;PKLR_9489;PAPSS2_33237;MPC2_33219;ME1_9215;LPL_32544;ITIH4_32725;ITIH3_32422;ITIH1_33132;IARS2_8858;HDC_8788;HADHB_8777;HADH_8776;HACL1_8775;GSTM7_8761;GPX4_32827;GLUL_32832;FMO1_32787;ETFDH_8575;EPHX2_33282;EPHX1_8567;EHHADH_8534;ECI2_8521;ECI1_8520;CYP7A1_8430;CYP2J4_32580;CYP2A1_32717;CYP17A1_32365;CROT_8384;CPS1_32421;CDO1_8275;CD36_8243;ASS1_33159;AMACR_8038;ALDH3A2_8024;ACOX1_7973;ACOT2_7969;ACOT12_32718;ACOT1_7968;ACADM_7957;ACADL_32776;ACAA2_7955;ABCG2_32656;ABCC2_32541;AASS_7936 34.236891481481486 30.77205 2.52378E-13 23.621808749174615 35.63688670740902 23.52653110328763 24.18424764814815 23.3534 2.52378E-13 15.129712608929186 24.8891630864179 14.447150723950772 57.25979740740741 41.62545 2.52379E-13 60.33896673220607 58.8112143694276 55.934895444617105 16.5 23.03005 33.5 39.22295 47.47345;50.1846;39.7166;7.62189;56.585;105.46;77.4407;2.52378E-13;42.4094;12.4414;23.0963;34.4443;46.8463;80.7944;74.2041;57.1163;27.1247;98.1741;24.7304;24.5745;31.8029;33.3125;17.6275;42.3152;45.9204;26.4669;65.2792;18.1231;38.7293;12.4747;8.62809;10.6467;11.9473;5.72128;17.8395;55.3937;49.6922;7.4229;31.9826;22.9638;48.1296;26.8037;2.03774;43.1079;23.1906;8.54905;30.3423;31.2018;11.7137;33.4878;26.5872;5.21654;46.2316;27.4644 34.82915;36.5009;22.6911;5.49916;35.2796;63.7532;58.7732;2.52378E-13;26.2988;8.48981;17.4625;25.719;35.8494;59.856;49.8682;39.6402;21.5108;42.9071;19.8021;21.0619;25.5756;25.7336;11.195;31.4035;34.2198;21.0456;39.7882;14.869;29.2097;7.00435;7.31865;8.92359;7.15307;0.985273;14.6501;38.7444;35.6654;5.75707;24.4836;18.5144;37.5433;20.9825;1.165;31.8774;16.2815;7.19676;24.0157;26.858;8.36151;26.6039;21.3695;2.73368;31.1788;21.7498 76.47475;80.9788;60.0334;13.3925;116.8;422.699;89.8047;2.52379E-13;81.7305;79.2355;32.9443;51.1014;69.127;94.0621;155.425;101.869;36.4819;104.278;32.7087;29.28;42.1484;46.9856;37.6534;64.5991;70.4292;35.4303;82.9415;23.0103;57.2113;23.684;10.3909;13.0581;19.001;22.3625;22.6149;96.8569;81.6409;10.316;45.5891;30.0179;69.1421;36.7081;3.73641;66.3058;33.4539;10.4125;41.1025;37.2719;18.9642;45.3228;35.0407;11.386;81.7848;37.0295 38 17 37 286954;360268;65192;246074;25106;100359982;24539;364070;24443;171155;113965;85255;81869;29328;25256;295143;65030;25315;171142;291075;29740;65210;24894;25146;83842;29184;25284;65183;50681;192272;170570;50559;24158;25287;170465;312382;296925 UGT2B10_33303,UGT2B1_33224;SULT1E1_32446;SLC27A2_9860;SCD1_9787;RGN_9699;MPC2_33219;LPL_32544;IARS2_8858;HDC_8788;HADHB_8777;HADH_8776;HACL1_8775;GSTM7_8761;GPX4_32827;FMO1_32787;ETFDH_8575;EPHX2_33282;EPHX1_8567;EHHADH_8534;ECI2_8521;ECI1_8520;CYP2J4_32580;CYP2A1_32717;CYP17A1_32365;CROT_8384;CD36_8243;AMACR_8038;ALDH3A2_8024;ACOX1_7973;ACOT2_7969;ACOT12_32718;ACOT1_7968;ACADM_7957;ACADL_32776;ACAA2_7955;ABCG2_32656;AASS_7936 32.884317837837834 30.3423 23.03604156385925 24.024440270270272 24.0157 15.468735020256807 56.25946648648649 37.6534 69.6816608988471 47.47345;50.1846;7.62189;105.46;77.4407;46.8463;74.2041;24.7304;24.5745;31.8029;33.3125;17.6275;42.3152;45.9204;65.2792;18.1231;38.7293;12.4747;8.62809;10.6467;11.9473;17.8395;55.3937;49.6922;7.4229;48.1296;2.03774;43.1079;23.1906;8.54905;30.3423;31.2018;11.7137;33.4878;26.5872;5.21654;27.4644 34.82915;36.5009;5.49916;63.7532;58.7732;35.8494;49.8682;19.8021;21.0619;25.5756;25.7336;11.195;31.4035;34.2198;39.7882;14.869;29.2097;7.00435;7.31865;8.92359;7.15307;14.6501;38.7444;35.6654;5.75707;37.5433;1.165;31.8774;16.2815;7.19676;24.0157;26.858;8.36151;26.6039;21.3695;2.73368;21.7498 76.47475;80.9788;13.3925;422.699;89.8047;69.127;155.425;32.7087;29.28;42.1484;46.9856;37.6534;64.5991;70.4292;82.9415;23.0103;57.2113;23.684;10.3909;13.0581;19.001;22.6149;96.8569;81.6409;10.316;69.1421;3.73641;66.3058;33.4539;10.4125;41.1025;37.2719;18.9642;45.3228;35.0407;11.386;37.0295 17 29573;29500;501907;83516;29441;24651;294103;24552;54404;50693;306251;24957;25428;497840;81718;25698;25303 SLC37A4_9871;SLC10A2_9833;RGD1559459_9690;PPARGC1A_33189;POR_9531;PKLR_9489;PAPSS2_33237;ME1_9215;ITIH4_32725;ITIH3_32422;ITIH1_33132;GLUL_32832;CYP7A1_8430;CPS1_32421;CDO1_8275;ASS1_33159;ABCC2_32541 37.180728235294126 31.9826 25.316392363808514 24.53206370588237 22.6911 14.821837366828934 59.43698823529413 51.1014 33.58300505979328 39.7166;56.585;2.52378E-13;42.4094;12.4414;23.0963;34.4443;80.7944;57.1163;27.1247;98.1741;26.4669;5.72128;31.9826;22.9638;26.8037;46.2316 22.6911;35.2796;2.52378E-13;26.2988;8.48981;17.4625;25.719;59.856;39.6402;21.5108;42.9071;21.0456;0.985273;24.4836;18.5144;20.9825;31.1788 60.0334;116.8;2.52379E-13;81.7305;79.2355;32.9443;51.1014;94.0621;101.869;36.4819;104.278;35.4303;22.3625;45.5891;30.0179;36.7081;81.7848 0 Exp 2,22(0.4);Exp 3,1(0.02);Exp 4,2(0.04);Hill,5(0.1);Linear,16(0.3);Poly 2,8(0.15);Power,1(0.02) 2.6490124576185123 529.6221796274185 1.5074360370635986 344.14306640625 46.209801568660154 1.893584966659546 27.93643029566512 40.53735266729787 20.148817167048946 28.21967812924734 41.16605446311178 73.35354035170305 UP 0.6851851851851852 0.3148148148148148 0.0 GO:0010883 4 regulation of lipid storage 20 22 4 4 4 4 4 4 158 18 2367 0.98937 0.046925 0.046925 18.18 298199;25493;24539;29184 plin2;nfkbia;lpl;cd36 PLIN2_9502;NFKBIA_9307;LPL_32544;CD36_8243 37.12638775 36.89065 0.520151 31.451086115158787 54.88837773459716 23.859066274278305 27.1242255 29.234250000000003 0.160202 21.535489855518364 39.387669565055944 15.041785302303232 65.1223975 51.0898 2.88499 66.01427513896287 99.89538181267406 59.42783219794498 0.5 13.0859255 1.5 36.89065 25.6517;0.520151;74.2041;48.1296 20.9252;0.160202;49.8682;37.5433 33.0375;2.88499;155.425;69.1421 3 1 3 298199;24539;29184 PLIN2_9502;LPL_32544;CD36_8243 49.328466666666664 48.1296 24.298391868667643 36.112233333333336 37.5433 14.52447162905878 85.8682 69.1421 62.88479033096956 25.6517;74.2041;48.1296 20.9252;49.8682;37.5433 33.0375;155.425;69.1421 1 25493 NFKBIA_9307 0.520151 0.520151 0.160202 0.160202 2.88499 2.88499 0.520151 0.160202 2.88499 0 Exp 2,3(0.75);Exp 4,1(0.25) 2.04162156271254 8.334044933319092 1.559399127960205 2.6703107357025146 0.48271903841764513 2.052167534828186 6.304323357144394 67.9484521428556 6.019445441592005 48.229005558408 0.42840786381637486 129.81638713618364 UP 0.75 0.25 0.0 GO:0032680 7 regulation of tumor necrosis factor production 62 64 8 8 7 8 7 7 155 57 2328 0.95276 0.10855 0.12266 10.94 79426;25513;24539;63868;24471;65210;29184 zfp36;pik3r1;lpl;hspd1;hspb1;cyp2j4;cd36 ZFP36_10204;PIK3R1_32562;LPL_32544;HSPD1_8849;HSPB1_8847;CYP2J4_32580;CD36_8243 41.516104857142864 42.2579 0.348134 32.019801207786486 49.303602112857824 29.497393615088754 28.303314571428576 23.9469 0.118102 21.803534384695972 34.01195013619826 19.85693854521791 71.20863142857144 69.1421 1.15962 53.903595127927986 83.7405742642045 52.173131218233074 2.5 30.49515 5.5 81.6526 0.348134;18.7324;74.2041;42.2579;89.1011;17.8395;48.1296 0.118102;11.6701;49.8682;23.9469;60.3265;14.6501;37.5433 1.15962;41.5978;155.425;102.383;106.138;22.6149;69.1421 4 3 4 24539;63868;65210;29184 LPL_32544;HSPD1_8849;CYP2J4_32580;CD36_8243 45.607775000000004 45.19375 23.140211493037384 31.502125 30.7451 15.436759997783433 87.39125 85.76255 55.92361070296398 74.2041;42.2579;17.8395;48.1296 49.8682;23.9469;14.6501;37.5433 155.425;102.383;22.6149;69.1421 3 79426;25513;24471 ZFP36_10204;PIK3R1_32562;HSPB1_8847 36.060544666666665 18.7324 46.845177891016554 24.038234000000003 11.6701 31.952947460493654 49.63180666666667 41.5978 52.94831455481972 0.348134;18.7324;89.1011 0.118102;11.6701;60.3265 1.15962;41.5978;106.138 0 Exp 2,2(0.29);Exp 3,1(0.15);Hill,1(0.15);Linear,1(0.15);Poly 2,2(0.29) 2.126429038443841 15.598614692687988 1.559399127960205 3.8079800605773926 0.7971379766760193 1.9381765127182007 17.795504169994828 65.23670554429088 12.151030259866225 44.45559888299092 31.276289333944547 111.14097352319833 CONFLICT 0.5714285714285714 0.42857142857142855 0.0 GO:0050769 7 positive regulation of neurogenesis 132 142 4 4 4 3 3 3 159 139 2246 0.015792 0.99577 0.031828 2.11 24825;24471;25661 tf;hspb1;fn1 TF_10003;HSPB1_8847;FN1_8655 64.6109 59.5777 45.1539 22.40176161912274 63.91380562730627 21.040801976805223 39.83613333333333 31.0499 28.132 17.805052083701792 38.68925598373029 17.00803392350631 90.9717 105.243 61.5341 25.497636685975436 92.68218334870848 24.581369041379773 45.1539;89.1011;59.5777 28.132;60.3265;31.0499 61.5341;106.138;105.243 1 2 1 24825 TF_10003 45.1539 45.1539 28.132 28.132 61.5341 61.5341 45.1539 28.132 61.5341 2 24471;25661 HSPB1_8847;FN1_8655 74.3394 74.3394 20.876196343682977 45.6882 45.6882 20.70168239008608 105.6905 105.6905 0.6328605691622222 89.1011;59.5777 60.3265;31.0499 106.138;105.243 0 Poly 2,2(0.67);Power,1(0.34) 1.769439269184093 5.311022400856018 1.6973176002502441 1.8344712257385254 0.0690079004605155 1.7792335748672485 39.26092032180023 89.96087967819977 19.68782017095069 59.984446495715986 62.118407887479506 119.82499211252049 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0043933 5 protein-containing complex subunit organization 226 259 19 18 14 14 10 10 152 249 2136 0.047826 0.97582 0.10519 3.86 29482;297784;298699;24539;29328;25661;361969;140942;25373;312382 slc1a2;rrs1;ppan;lpl;gpx4;fn1;fga;ddit4;ahsg;abcg2 SLC1A2_33059;RRS1_9755;PPAN_9534;LPL_32544;GPX4_32827;FN1_8655;FGA_8632;DDIT4_8450;AHSG_8003;ABCG2_32656 44.484553999999996 51.804649999999995 5.21654 28.263895567789977 43.16625546464486 26.54504324922718 29.75316 32.63485 2.73368 17.882758900363587 28.61874198339984 17.10592448753083 87.00431999999999 84.30165 11.386 72.95278282223678 79.53219236073426 59.571063505362524 13.3235;60.39;57.6889;74.2041;45.9204;59.5777;28.5803;87.5421;12.402;5.21654 9.10952;43.109;41.3659;49.8682;34.2198;31.0499;22.529;53.2453;10.3013;2.73368 24.6773;104.942;98.1741;155.425;70.4292;105.243;38.8511;245.492;15.4235;11.386 5 5 5 297784;298699;24539;29328;312382 RRS1_9755;PPAN_9534;LPL_32544;GPX4_32827;ABCG2_32656 48.683988 57.6889 26.298534787278935 34.259316 41.3659 18.48191676675556 88.07126 98.1741 52.71405628129941 60.39;57.6889;74.2041;45.9204;5.21654 43.109;41.3659;49.8682;34.2198;2.73368 104.942;98.1741;155.425;70.4292;11.386 5 29482;25661;361969;140942;25373 SLC1A2_33059;FN1_8655;FGA_8632;DDIT4_8450;AHSG_8003 40.28512 28.5803 32.58383781481242 25.247004 22.529 18.0883815233724 85.93737999999999 38.8511 95.88079339136175 13.3235;59.5777;28.5803;87.5421;12.402 9.10952;31.0499;22.529;53.2453;10.3013 24.6773;105.243;38.8511;245.492;15.4235 0 Exp 2,5(0.5);Exp 4,1(0.1);Linear,2(0.2);Poly 2,1(0.1);Power,1(0.1) 1.8085879040956858 18.710146188735962 1.5074360370635986 3.431420087814331 0.5933092603391779 1.6437667608261108 26.966410033502555 62.002697966497436 18.66931120133178 40.83700879866822 41.78771674828854 132.22092325171147 CONFLICT 0.5 0.5 0.0 GO:0006264 8 mitochondrial DNA replication 4 4 2 2 1 2 1 1 161 3 2382 0.97784 0.23128 0.23128 25.0 303612 polg2 POLG2_9521 63.7758 63.7758 63.7758 63.7758 40.9553 40.9553 40.9553 40.9553 132.567 132.567 132.567 132.567 0.0 63.7758 0.0 63.7758 63.7758 40.9553 132.567 0 1 0 1 303612 POLG2_9521 63.7758 63.7758 40.9553 40.9553 132.567 132.567 63.7758 40.9553 132.567 0 Exp 2,1(1) 1.5504547357559204 1.5504547357559204 1.5504547357559204 1.5504547357559204 0.0 1.5504547357559204 63.7758 63.7758 40.9553 40.9553 132.567 132.567 DOWN 0.0 1.0 0.0 GO:1903047 4 mitotic cell cycle process 136 146 10 10 8 8 6 6 156 140 2245 0.16524 0.91438 0.29757 4.11 257644;297784;499914;25112;116636;114851 zwint;rrs1;gins1;gadd45a;eif4ebp1;cdkn1a ZWINT_10214;RRS1_9755;GINS1_8707;GADD45A_8678;EIF4EBP1_8550;CDKN1A_8271 60.729261666666666 59.65325 6.24967 32.75510235974875 60.62247338179055 37.47058083937309 43.515208333333334 42.76375 2.44025 27.662144392227013 44.23852980878815 32.1503954406477 86.57631666666667 98.3895 19.0606 35.26824624686724 83.79646201089021 39.98672251275874 52.0003;60.39;58.9165;102.919;83.9001;6.24967 38.9015;43.109;44.7208;89.5012;42.4185;2.44025 80.8613;104.942;91.837;115.437;107.32;19.0606 4 2 4 257644;297784;499914;116636 ZWINT_10214;RRS1_9755;GINS1_8707;EIF4EBP1_8550 63.801725000000005 59.65325 13.889127647762212 42.28745 42.76375 2.454789069689427 96.240075 98.3895 12.306936075068883 52.0003;60.39;58.9165;83.9001 38.9015;43.109;44.7208;42.4185 80.8613;104.942;91.837;107.32 2 25112;114851 GADD45A_8678;CDKN1A_8271 54.584334999999996 54.584334999999996 68.35553877576015 45.970725 45.970725 61.56138812154295 67.2488 67.2488 68.14840598634717 102.919;6.24967 89.5012;2.44025 115.437;19.0606 0 Exp 2,3(0.5);Exp 3,1(0.17);Exp 4,1(0.17);Poly 2,1(0.17) 1.682580937626866 10.203239798545837 1.5207922458648682 2.281954288482666 0.2912122004317206 1.602768063545227 34.51972116368758 86.93880216964575 21.380882942298552 65.64953372436811 58.35584224030013 114.79679109303322 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0052697 8 xenobiotic glucuronidation 1 7 1 1 1 1 1 1 161 6 2379 0.93166 0.36908 0.36908 14.29 501907 rgd1559459 RGD1559459_9690 2.52378E-13 2.52378E-13 2.52378E-13 2.52378E-13 2.52378E-13 2.52378E-13 2.52378E-13 2.52378E-13 2.52379E-13 2.52379E-13 2.52379E-13 2.52379E-13 0.0 2.52378E-13 0.0 2.52378E-13 2.52378E-13 2.52378E-13 2.52379E-13 0 1 0 1 501907 RGD1559459_9690 2.52378E-13 2.52378E-13 2.52378E-13 2.52378E-13 2.52379E-13 2.52379E-13 2.52378E-13 2.52378E-13 2.52379E-13 0 Hill,1(1) 1.6167030334472656 1.6167030334472656 1.6167030334472656 1.6167030334472656 0.0 1.6167030334472656 2.52378E-13 2.52378E-13 2.52378E-13 2.52378E-13 2.52379E-13 2.52379E-13 DOWN 0.0 1.0 0.0 GO:0060255 5 regulation of macromolecule metabolic process 1000 1070 88 88 74 76 65 65 97 1005 1380 0.33826 0.71983 0.681 6.07 79426;24522;308843;246273;24825;170698;29573;293615;79224;24794;24648;25106;252922;192280;83516;29441;303612;363465;25513;81819;25591;81525;25493;24539;299282;288001;58954;24516;54404;50693;306251;494344;63868;24471;25675;290556;29455;299626;25112;294515;314322;25661;361969;83928;24360;308441;24890;29496;65030;116636;24330;116663;140942;25428;65210;25423;113936;25695;114851;29184;79431;155423;25377;25373;25303 zfp36;zfp354a;tsku;trib3;tf;slco1a2;slc37a4;sirt3;serpind1;serpina3c;serpina1;rgn;pzp;ppp1r3b;ppargc1a;por;polg2;pir;pik3r1;pax8;parp1;nfkbib;nfkbia;lpl;loc299282;kng1;klf6;jun;itih4;itih3;itih1;ier2;hspd1;hspb1;hmgcr;gnl3;gdf15;gadd45b;gadd45a;foxo3;fos;fn1;fga;fetub;fabp1;exosc5;esr1;erbb3;ephx2;eif4ebp1;egr1;dusp6;ddit4;cyp7a1;cyp2j4;ctsc;cpb2;cebpd;cdkn1a;cd36;bhlhe40;anxa7;ambp;ahsg;abcc2 ZFP36_10204;ZFP354A_10203;TSKU_10094;TRIB3_10079;TF_10003;SLCO1A2_9886;SLC37A4_9871;SIRT3_9828;SERPIND1_9812;SERPINA3C_32925;SERPINA1_9807;RGN_9699;PZP_9633;PPP1R3B_9545;PPARGC1A_33189;POR_9531;POLG2_9521;PIR_9487;PIK3R1_32562;PAX8_9432;PARP1_9425;NFKBIB_9308;NFKBIA_9307;LPL_32544;LOC299282_9119;KNG1L1_34113;KLF6_8969;JUN_8938;ITIH4_32725;ITIH3_32422;ITIH1_33132;IER2_32643;HSPD1_8849;HSPB1_8847;HMGCR_8810;GNL3_8735;GDF15_33113;GADD45B_8679;GADD45A_8678;FOXO3_8662;FOS_8657;FN1_8655;FGA_8632;FETUB_33027;FABP1_33091;EXOSC5_32543;ESR1_33192;ERBB3_8571;EPHX2_33282;EIF4EBP1_8550;EGR1_8533;DUSP6_8506;DDIT4_8450;CYP7A1_8430;CYP2J4_32580;CTSC_32456;CPB2_8369;CEBPD_8283;CDKN1A_8271;CD36_8243;BHLHE40_8141;ANXA7_8051;AMBP_33085;AHSG_8003;ABCC2_32541 42.127874538461555 36.1411 1.28141E-12 32.23661447899424 45.14190512675421 30.568802165718406 28.38510977230771 26.2988 1.28141E-12 21.960036162666405 30.55874676160475 21.451959953565442 67.70625753846156 57.2113 1.28142E-12 52.250405773323585 70.18265376003487 44.29557898926198 52.5 75.8224 0.348134;0.834827;1.38416;108.064;45.1539;104.197;39.7166;2.38018;28.261;29.766;15.797;77.4407;34.1871;36.1411;42.4094;12.4414;63.7758;50.0307;18.7324;56.8931;26.9741;30.5572;0.520151;74.2041;45.2017;24.3655;18.9476;16.4324;57.1163;27.1247;98.1741;49.6814;42.2579;89.1011;1.63089;87.6357;105.149;106.367;102.919;13.1992;1.28141E-12;59.5777;28.5803;32.5155;33.8478;41.9329;23.3972;60.9984;38.7293;83.9001;0.750017;62.3934;87.5421;5.72128;17.8395;56.2386;25.8316;0.306936;6.24967;48.1296;57.8085;104.64;17.2343;12.402;46.2316 0.118102;0.27095;0.540568;83.8836;28.132;80.3101;22.6911;0.56209;22.307;23.347;13.013;58.7732;26.3085;27.0588;26.2988;8.48981;40.9553;38.7717;11.6701;45.1162;21.799;24.2439;0.160202;49.8682;30.7472;19.538;11.6941;10.5224;39.6402;21.5108;42.9071;33.4626;23.9469;60.3265;0.663137;54.41;85.3487;52.7132;89.5012;5.6804;1.28141E-12;31.0499;22.529;19.6094;26.4736;31.7336;18.3088;41.6036;29.2097;42.4185;0.186019;39.0875;53.2453;0.985273;14.6501;38.2681;20.4374;0.0732342;2.44025;37.5433;38.3491;43.9254;14.1233;10.3013;31.1788 1.15962;2.99857;4.10872;143.428;61.5341;128.412;60.0334;8.82917;38.3264;40.8256;19.9134;89.8047;48.5666;53.6244;81.7305;79.2355;132.567;73.0083;41.5978;81.5688;35.2797;41.2611;2.88499;155.425;78.6415;32.1467;45.5481;39.929;101.869;36.4819;104.278;89.4404;102.383;106.138;7.6286;238.963;125.652;109.434;115.437;32.7581;1.28142E-12;105.243;38.8511;49.9875;46.9257;62.1373;31.9156;113.972;57.2113;107.32;4.70178;133.304;245.492;22.3625;22.6149;102.888;34.8042;1.73689;19.0606;69.1421;110.58;108.689;21.9073;15.4235;81.7848 19 46 19 24825;293615;25106;363465;81819;25591;81525;24539;63868;290556;299626;24360;308441;29496;65030;116636;65210;29184;155423 TF_10003;SIRT3_9828;RGN_9699;PIR_9487;PAX8_9432;PARP1_9425;NFKBIB_9308;LPL_32544;HSPD1_8849;GNL3_8735;GADD45B_8679;FABP1_33091;EXOSC5_32543;ERBB3_8571;EPHX2_33282;EIF4EBP1_8550;CYP2J4_32580;CD36_8243;ANXA7_8051 54.20590421052632 48.1296 28.528467414514292 35.047062631578946 37.5433 14.821742599572286 83.44753526315789 73.0083 52.2923691187269 45.1539;2.38018;77.4407;50.0307;56.8931;26.9741;30.5572;74.2041;42.2579;87.6357;106.367;33.8478;41.9329;60.9984;38.7293;83.9001;17.8395;48.1296;104.64 28.132;0.56209;58.7732;38.7717;45.1162;21.799;24.2439;49.8682;23.9469;54.41;52.7132;26.4736;31.7336;41.6036;29.2097;42.4185;14.6501;37.5433;43.9254 61.5341;8.82917;89.8047;73.0083;81.5688;35.2797;41.2611;155.425;102.383;238.963;109.434;46.9257;62.1373;113.972;57.2113;107.32;22.6149;69.1421;108.689 46 79426;24522;308843;246273;170698;29573;79224;24794;24648;252922;192280;83516;29441;303612;25513;25493;299282;288001;58954;24516;54404;50693;306251;494344;24471;25675;29455;25112;294515;314322;25661;361969;83928;24890;24330;116663;140942;25428;25423;113936;25695;114851;79431;25377;25373;25303 ZFP36_10204;ZFP354A_10203;TSKU_10094;TRIB3_10079;SLCO1A2_9886;SLC37A4_9871;SERPIND1_9812;SERPINA3C_32925;SERPINA1_9807;PZP_9633;PPP1R3B_9545;PPARGC1A_33189;POR_9531;POLG2_9521;PIK3R1_32562;NFKBIA_9307;LOC299282_9119;KNG1L1_34113;KLF6_8969;JUN_8938;ITIH4_32725;ITIH3_32422;ITIH1_33132;IER2_32643;HSPB1_8847;HMGCR_8810;GDF15_33113;GADD45A_8678;FOXO3_8662;FOS_8657;FN1_8655;FGA_8632;FETUB_33027;ESR1_33192;EGR1_8533;DUSP6_8506;DDIT4_8450;CYP7A1_8430;CTSC_32456;CPB2_8369;CEBPD_8283;CDKN1A_8271;BHLHE40_8141;AMBP_33085;AHSG_8003;ABCC2_32541 37.139123152173944 28.420650000000002 32.64029725129159 25.633433591304374 21.9089 23.906159679276204 61.20442543478263 43.57295 51.39245421947174 0.348134;0.834827;1.38416;108.064;104.197;39.7166;28.261;29.766;15.797;34.1871;36.1411;42.4094;12.4414;63.7758;18.7324;0.520151;45.2017;24.3655;18.9476;16.4324;57.1163;27.1247;98.1741;49.6814;89.1011;1.63089;105.149;102.919;13.1992;1.28141E-12;59.5777;28.5803;32.5155;23.3972;0.750017;62.3934;87.5421;5.72128;56.2386;25.8316;0.306936;6.24967;57.8085;17.2343;12.402;46.2316 0.118102;0.27095;0.540568;83.8836;80.3101;22.6911;22.307;23.347;13.013;26.3085;27.0588;26.2988;8.48981;40.9553;11.6701;0.160202;30.7472;19.538;11.6941;10.5224;39.6402;21.5108;42.9071;33.4626;60.3265;0.663137;85.3487;89.5012;5.6804;1.28141E-12;31.0499;22.529;19.6094;18.3088;0.186019;39.0875;53.2453;0.985273;38.2681;20.4374;0.0732342;2.44025;38.3491;14.1233;10.3013;31.1788 1.15962;2.99857;4.10872;143.428;128.412;60.0334;38.3264;40.8256;19.9134;48.5666;53.6244;81.7305;79.2355;132.567;41.5978;2.88499;78.6415;32.1467;45.5481;39.929;101.869;36.4819;104.278;89.4404;106.138;7.6286;125.652;115.437;32.7581;1.28142E-12;105.243;38.8511;49.9875;31.9156;4.70178;133.304;245.492;22.3625;102.888;34.8042;1.73689;19.0606;110.58;21.9073;15.4235;81.7848 0 Exp 2,23(0.36);Exp 3,4(0.07);Exp 4,4(0.07);Hill,8(0.13);Linear,11(0.17);Poly 2,13(0.2);Power,2(0.04) 1.9231739803187737 131.47082483768463 1.5197933912277222 4.642963409423828 0.7782058334550371 1.7198865413665771 34.29089309338646 49.964855983536665 23.046447548576445 33.72377199603898 55.00376172240719 80.40875335451592 DOWN 0.2923076923076923 0.7076923076923077 0.0 GO:0090087 6 regulation of peptide transport 199 214 24 23 16 21 14 14 148 200 2185 0.61524 0.49872 0.88361 6.54 293615;25513;81819;25591;100359982;24539;63868;25675;113965;24957;25661;361969;65210;29184 sirt3;pik3r1;pax8;parp1;mpc2;lpl;hspd1;hmgcr;hadh;glul;fn1;fga;cyp2j4;cd36 SIRT3_9828;PIK3R1_32562;PAX8_9432;PARP1_9425;MPC2_33219;LPL_32544;HSPD1_8849;HMGCR_8810;HADH_8776;GLUL_32832;FN1_8655;FGA_8632;CYP2J4_32580;CD36_8243 34.55896214285714 30.9464 1.63089 21.30540659494032 39.74154222599941 20.247821372497736 24.430466214285712 23.237949999999998 0.56209 14.77557906317013 27.94768768642064 13.537394379477847 58.579005 44.2917 7.6286 41.58579681651541 66.74015800706044 42.42091542514493 9.5 47.48795 2.38018;18.7324;56.8931;26.9741;46.8463;74.2041;42.2579;1.63089;33.3125;26.4669;59.5777;28.5803;17.8395;48.1296 0.56209;11.6701;45.1162;21.799;35.8494;49.8682;23.9469;0.663137;25.7336;21.0456;31.0499;22.529;14.6501;37.5433 8.82917;41.5978;81.5688;35.2797;69.127;155.425;102.383;7.6286;46.9856;35.4303;105.243;38.8511;22.6149;69.1421 9 5 9 293615;81819;25591;100359982;24539;63868;113965;65210;29184 SIRT3_9828;PAX8_9432;PARP1_9425;MPC2_33219;LPL_32544;HSPD1_8849;HADH_8776;CYP2J4_32580;CD36_8243 38.759697777777774 42.2579 21.44833272774471 28.340976666666663 25.7336 15.46730045892463 65.70614111111111 69.127 44.774252556267896 2.38018;56.8931;26.9741;46.8463;74.2041;42.2579;33.3125;17.8395;48.1296 0.56209;45.1162;21.799;35.8494;49.8682;23.9469;25.7336;14.6501;37.5433 8.82917;81.5688;35.2797;69.127;155.425;102.383;46.9856;22.6149;69.1421 5 25513;25675;24957;25661;361969 PIK3R1_32562;HMGCR_8810;GLUL_32832;FN1_8655;FGA_8632 26.997638000000002 26.4669 21.07150329857174 17.3915474 21.0456 11.606795318137292 45.75016 38.8511 35.93045359083293 18.7324;1.63089;26.4669;59.5777;28.5803 11.6701;0.663137;21.0456;31.0499;22.529 41.5978;7.6286;35.4303;105.243;38.8511 0 Exp 2,5(0.36);Exp 3,1(0.08);Exp 4,1(0.08);Hill,1(0.08);Linear,4(0.29);Poly 2,1(0.08);Power,1(0.08) 1.971531948673194 28.516661524772644 1.5209722518920898 3.8079800605773926 0.6074804591873214 1.8552199006080627 23.398507667871847 45.71941661784242 16.690544577905506 32.17038785066592 36.79503246192468 80.36297753807531 UP 0.6428571428571429 0.35714285714285715 0.0 GO:0042220 5 response to cocaine 23 24 2 2 2 2 2 2 160 22 2363 0.80695 0.45749 0.66251 8.33 63868;24330 hspd1;egr1 HSPD1_8849;EGR1_8533 21.5039585 21.5039585 0.750017 29.350505541997816 21.160504776590614 29.346486240274096 12.0664595 12.0664595 0.186019 16.80148008206659 11.869851953165167 16.799179262485875 53.54239 53.54239 4.70178 69.07105305657501 52.7341344039203 69.06159436421237 0.5 21.5039585 42.2579;0.750017 23.9469;0.186019 102.383;4.70178 1 1 1 63868 HSPD1_8849 42.2579 42.2579 23.9469 23.9469 102.383 102.383 42.2579 23.9469 102.383 1 24330 EGR1_8533 0.750017 0.750017 0.186019 0.186019 4.70178 4.70178 0.750017 0.186019 4.70178 0 Exp 3,1(0.5);Hill,1(0.5) 3.08203648449593 6.4701361656188965 2.2518506050109863 4.21828556060791 1.3904794918648524 3.2350680828094482 -19.173766839999995 62.18168383999999 -11.219203879999995 35.352122879999996 -42.18520559999999 149.26998559999998 CONFLICT 0.5 0.5 0.0 GO:0007631 3 feeding behavior 14 16 4 4 3 4 3 3 159 13 2372 0.98429 0.076773 0.076773 18.75 29455;314322;29184 gdf15;fos;cd36 GDF15_33113;FOS_8657;CD36_8243 51.0928666666671 48.1296 1.28141E-12 52.637094926043055 63.73473250760556 44.37377693272938 40.964000000000425 37.5433 1.28141E-12 42.777050380898714 50.99660803998278 36.4162149564631 64.93136666666709 69.1421 1.28142E-12 62.9317406592512 81.784194806606 50.47691228239915 0.0 1.28141E-12 0.5 24.06480000000064 105.149;1.28141E-12;48.1296 85.3487;1.28141E-12;37.5433 125.652;1.28142E-12;69.1421 1 2 1 29184 CD36_8243 48.1296 48.1296 37.5433 37.5433 69.1421 69.1421 48.1296 37.5433 69.1421 2 29455;314322 GDF15_33113;FOS_8657 52.57450000000064 52.57450000000064 74.35157093498339 42.674350000000636 42.674350000000636 60.35064453545538 62.82600000000064 62.82600000000064 88.84938126965116 105.149;1.28141E-12 85.3487;1.28141E-12 125.652;1.28142E-12 0 Exp 2,1(0.34);Hill,1(0.34);Poly 2,1(0.34) 1.9919720495301596 6.127596735954285 1.5606178045272827 2.6703107357025146 0.5690446740792452 1.8966681957244873 -8.471613546158167 110.65734687949235 -7.4427894429977 89.37078944299856 -6.282601857306091 136.14533519064025 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0006957 8 complement activation, alternative pathway 4 4 1 1 1 1 1 1 161 3 2382 0.97784 0.23128 0.23128 25.0 313421 c8b C8B_8181 21.3618 21.3618 21.3618 21.3618 17.2088 17.2088 17.2088 17.2088 27.9161 27.9161 27.9161 27.9161 0.0 21.3618 0.0 21.3618 21.3618 17.2088 27.9161 0 1 0 1 313421 C8B_8181 21.3618 21.3618 17.2088 17.2088 27.9161 27.9161 21.3618 17.2088 27.9161 0 Exp 2,1(1) 1.5122476816177368 1.5122476816177368 1.5122476816177368 1.5122476816177368 0.0 1.5122476816177368 21.3618 21.3618 17.2088 17.2088 27.9161 27.9161 DOWN 0.0 1.0 0.0 GO:0070542 5 response to fatty acid 60 63 13 13 10 12 9 9 153 54 2331 0.99445 0.016496 0.016496 14.29 246074;83516;25513;24539;24471;25661;497840;29184;25698 scd;ppargc1a;pik3r1;lpl;hspb1;fn1;cps1;cd36;ass1 SCD1_9787;PPARGC1A_33189;PIK3R1_32562;LPL_32544;HSPB1_8847;FN1_8655;CPS1_32421;CD36_8243;ASS1_33159 55.15562222222222 48.1296 18.7324 29.46295958817519 56.83267973535939 25.625484705640762 36.21956666666667 31.0499 11.6701 18.114245614984906 37.36256092026635 16.036509533665583 118.25251111111112 81.7305 36.7081 120.38301587753614 110.16010927607991 96.30671005289007 2.5 37.196 5.5 66.8909 105.46;42.4094;18.7324;74.2041;89.1011;59.5777;31.9826;48.1296;26.8037 63.7532;26.2988;11.6701;49.8682;60.3265;31.0499;24.4836;37.5433;20.9825 422.699;81.7305;41.5978;155.425;106.138;105.243;45.5891;69.1421;36.7081 3 6 3 246074;24539;29184 SCD1_9787;LPL_32544;CD36_8243 75.93123333333334 74.2041 28.70419713566871 50.38823333333334 49.8682 13.112686242846392 215.75536666666667 155.425 184.33782911004278 105.46;74.2041;48.1296 63.7532;49.8682;37.5433 422.699;155.425;69.1421 6 83516;25513;24471;25661;497840;25698 PPARGC1A_33189;PIK3R1_32562;HSPB1_8847;FN1_8655;CPS1_32421;ASS1_33159 44.76781666666667 37.196 25.9011542540804 29.135233333333336 25.391199999999998 16.59965092761491 69.50108333333334 63.659800000000004 32.23371782921828 42.4094;18.7324;89.1011;59.5777;31.9826;26.8037 26.2988;11.6701;60.3265;31.0499;24.4836;20.9825 81.7305;41.5978;106.138;105.243;45.5891;36.7081 0 Exp 2,6(0.67);Poly 2,2(0.23);Power,1(0.12) 1.8734699947943614 17.082191348075867 1.559399127960205 2.6703107357025146 0.3456432231187883 1.7792335748672485 35.906488624614425 74.40475581983 24.38492619820986 48.05420713512347 39.602274071120846 196.90274815110138 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0034644 7 cellular response to UV 32 34 5 5 5 4 4 4 158 30 2355 0.93913 0.16664 0.27209 11.76 25513;25591;114851;246142 pik3r1;parp1;cdkn1a;bmf PIK3R1_32562;PARP1_9425;CDKN1A_8271;BMF_8152 36.7082175 22.85325 6.24967 39.703813966501485 41.74439210912907 43.40558337723205 27.260887500000003 16.73455 2.44025 31.58760155272886 31.412808445316998 34.375734164971824 51.446524999999994 38.43875 19.0606 40.07469706680057 55.18262907287682 44.554324724122274 0.5 12.491035 2.5 60.925399999999996 18.7324;26.9741;6.24967;94.8767 11.6701;21.799;2.44025;73.1342 41.5978;35.2797;19.0606;109.848 2 2 2 25591;246142 PARP1_9425;BMF_8152 60.925399999999996 60.925399999999996 48.014388920197675 47.4666 47.4666 36.29946803356768 72.56385 72.56385 52.727750591552805 26.9741;94.8767 21.799;73.1342 35.2797;109.848 2 25513;114851 PIK3R1_32562;CDKN1A_8271 12.491035 12.491035 8.826623030720748 7.055175 7.055175 6.526489524334655 30.3292 30.3292 15.936206948957466 18.7324;6.24967 11.6701;2.44025 41.5978;19.0606 0 Exp 2,1(0.25);Exp 4,1(0.25);Poly 2,2(0.5) 1.6732081042323736 6.705531716346741 1.522104263305664 1.8086696863174438 0.11821496021102354 1.6873788833618164 -2.201520187171461 75.61795518717145 -3.694962021674275 58.21673702167428 12.173321874535453 90.71972812546454 CONFLICT 0.5 0.5 0.0 GO:0007017 3 microtubule-based process 97 110 4 4 3 4 3 3 159 107 2278 0.07092 0.97601 0.15751 2.73 296554;24471;25112 tubb4b;hspb1;gadd45a TUBB4B_34097;HSPB1_8847;GADD45A_8678 84.9268 89.1011 62.7603 20.402178358940038 86.94119234151376 20.249279479764965 65.63976666666667 60.3265 47.0916 21.698309727795202 68.10050911211809 22.23936774070523 107.70100000000001 106.138 101.528 7.085005081155725 108.50188568352102 7.251427998610157 62.7603;89.1011;102.919 47.0916;60.3265;89.5012 101.528;106.138;115.437 1 2 1 296554 TUBB4B_34097 62.7603 62.7603 47.0916 47.0916 101.528 101.528 62.7603 47.0916 101.528 2 24471;25112 HSPB1_8847;GADD45A_8678 96.01005 96.01005 9.770730791757396 74.91385 74.91385 20.62962820908318 110.7875 110.7875 6.5753859582538015 89.1011;102.919 60.3265;89.5012 106.138;115.437 0 Exp 2,1(0.34);Poly 2,2(0.67) 1.6581629854022233 4.975184082984924 1.6339634656906128 1.6973176002502441 0.0340726154607025 1.6439030170440674 61.83956179152601 108.01403820847399 41.085817740553864 90.19371559277948 99.68356200200255 115.71843799799744 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0006959 4 humoral immune response 62 73 4 4 3 3 2 2 160 71 2314 0.14534 0.95304 0.32413 2.74 361969;313421 fga;c8b FGA_8632;C8B_8181 24.971049999999998 24.971049999999998 21.3618 5.104250299995117 26.517068739783607 4.6122687733344225 19.8689 19.8689 17.2088 3.761949497268665 21.008351257102824 3.3993478323604673 33.3836 33.3836 27.9161 7.732212652274877 35.72559832645754 6.986930669309604 28.5803;21.3618 22.529;17.2088 38.8511;27.9161 0 2 0 2 361969;313421 FGA_8632;C8B_8181 24.971049999999998 24.971049999999998 5.104250299995117 19.8689 19.8689 3.761949497268665 33.3836 33.3836 7.732212652274877 28.5803;21.3618 22.529;17.2088 38.8511;27.9161 0 Exp 2,1(0.5);Linear,1(0.5) 1.5269998196628458 3.05414354801178 1.5122476816177368 1.541895866394043 0.020964432505197843 1.52707177400589 17.896919999999994 32.04518 14.655104000000001 25.082696 22.667299999999997 44.099900000000005 DOWN 0.0 1.0 0.0 GO:0000302 5 response to reactive oxygen species 109 115 14 14 13 13 12 12 150 103 2282 0.97182 0.058049 0.076508 10.43 83516;25591;24314;58954;24516;63868;24471;24464;314322;25661;24360;65183 ppargc1a;parp1;nqo1;klf6;jun;hspd1;hspb1;hp;fos;fn1;fabp1;aldh3a2 PPARGC1A_33189;PARP1_9425;NQO1_33055;KLF6_8969;JUN_8938;HSPD1_8849;HSPB1_8847;HP_8823;FOS_8657;FN1_8655;FABP1_33091;ALDH3A2_8024 43.73840833333344 42.33365 1.28141E-12 27.485061851765387 46.60419013515757 23.58782322707565 28.858175000000106 26.386200000000002 1.28141E-12 18.41548748734565 30.15454252414608 15.183164998558965 80.25456666666678 74.01815 1.28142E-12 53.25849705729975 81.1166416200823 40.84196532636818 4.5 38.05285 10.5 88.1888 42.4094;26.9741;87.2765;18.9476;16.4324;42.2579;89.1011;64.9285;1.28141E-12;59.5777;33.8478;43.1079 26.2988;21.799;60.6992;11.6941;10.5224;23.9469;60.3265;41.6103;1.28141E-12;31.0499;26.4736;31.8774 81.7305;35.2797;197.117;45.5481;39.929;102.383;106.138;136.455;1.28142E-12;105.243;46.9257;66.3058 5 7 5 25591;24314;63868;24360;65183 PARP1_9425;NQO1_33055;HSPD1_8849;FABP1_33091;ALDH3A2_8024 46.692840000000004 42.2579 23.62931286766502 32.95922 26.4736 15.957071425609406 89.60224000000001 66.3058 65.26431065125102 26.9741;87.2765;42.2579;33.8478;43.1079 21.799;60.6992;23.9469;26.4736;31.8774 35.2797;197.117;102.383;46.9257;66.3058 7 83516;58954;24516;24471;24464;314322;25661 PPARGC1A_33189;KLF6_8969;JUN_8938;HSPB1_8847;HP_8823;FOS_8657;FN1_8655 41.62810000000018 42.4094 31.626781971824382 25.92885714285733 26.2988 20.68719526348395 73.57765714285733 81.7305 47.28364549615605 42.4094;18.9476;16.4324;89.1011;64.9285;1.28141E-12;59.5777 26.2988;11.6941;10.5224;60.3265;41.6103;1.28141E-12;31.0499 81.7305;45.5481;39.929;106.138;136.455;1.28142E-12;105.243 0 Exp 2,5(0.42);Exp 3,1(0.09);Hill,1(0.09);Linear,1(0.09);Poly 2,3(0.25);Power,1(0.09) 1.7687921990951008 21.350035786628723 1.520427942276001 2.2518506050109863 0.2057008284861767 1.7684283256530762 28.187270631699388 59.289546034967486 18.438632075084456 39.27771792491576 50.120735206253215 110.38839812708034 CONFLICT 0.4166666666666667 0.5833333333333334 0.0 GO:0048771 3 tissue remodeling 36 39 2 2 2 2 2 2 160 37 2348 0.5439 0.72107 1.0 5.13 85253;29496 plg;erbb3 PLG_9501;ERBB3_8571 65.89205 65.89205 60.9984 6.920666199507114 66.48127186496325 6.8703170110773515 43.9196 43.9196 41.6036 3.275318610456001 44.19845889658126 3.2514900325228164 132.2755 132.2755 113.972 25.88505793889608 134.47934016130185 25.69673912361002 0.5 65.89205 70.7857;60.9984 46.2356;41.6036 150.579;113.972 1 1 1 29496 ERBB3_8571 60.9984 60.9984 41.6036 41.6036 113.972 113.972 60.9984 41.6036 113.972 1 85253 PLG_9501 70.7857 70.7857 46.2356 46.2356 150.579 150.579 70.7857 46.2356 150.579 0 Linear,2(1) 1.5629259789803744 3.1267716884613037 1.5254690647125244 1.6013026237487793 0.053622423836046214 1.5633858442306519 56.30049599999999 75.483604 39.38024000000001 48.45896 96.40063999999998 168.15036 CONFLICT 0.5 0.5 0.0 GO:0120162 5 positive regulation of cold-induced thermogenesis 37 42 10 10 7 9 6 6 156 36 2349 0.98495 0.047034 0.047034 14.29 246074;83516;113965;289388;29184;25287 scd;ppargc1a;hadh;g0s2;cd36;acadl SCD1_9787;PPARGC1A_33189;HADH_8776;G0S2_32729;CD36_8243;ACADL_32776 51.52961666666667 44.3939 33.3125 27.155589602467966 49.424529611619015 24.07370874933739 35.6207 30.197650000000003 25.7336 14.590651347763751 34.79647945924917 13.160885114903849 123.25548333333334 71.39750000000001 45.3228 147.42456829095235 108.7302564611295 130.5478491337551 1.5 37.9486 3.5 47.254000000000005 105.46;42.4094;33.3125;46.3784;48.1296;33.4878 63.7532;26.2988;25.7336;33.7914;37.5433;26.6039 422.699;81.7305;46.9856;73.6529;69.1421;45.3228 5 1 5 246074;113965;289388;29184;25287 SCD1_9787;HADH_8776;G0S2_32729;CD36_8243;ACADL_32776 53.353660000000005 46.3784 29.947104245786427 37.485079999999996 33.7914 15.493209401444238 131.56048 69.1421 163.24891086150316 105.46;33.3125;46.3784;48.1296;33.4878 63.7532;25.7336;33.7914;37.5433;26.6039 422.699;46.9856;73.6529;69.1421;45.3228 1 83516 PPARGC1A_33189 42.4094 42.4094 26.2988 26.2988 81.7305 81.7305 42.4094 26.2988 81.7305 0 Exp 2,4(0.67);Linear,2(0.34) 2.112717785292674 12.801368594169617 1.7576230764389038 2.6703107357025146 0.33240791491795957 2.100488841533661 29.800619524444894 73.25861380888844 23.945747399821535 47.295652600178464 5.291260498110873 241.21970616855577 UP 0.8333333333333334 0.16666666666666666 0.0 GO:0001525 4 angiogenesis 67 72 4 4 4 3 3 3 159 69 2316 0.31686 0.84804 0.62383 4.17 24516;24957;25661 jun;glul;fn1 JUN_8938;GLUL_32832;FN1_8655 34.159 26.4669 16.4324 22.577766271932216 42.94213410508569 23.259293147878324 20.872633333333333 21.0456 10.5224 10.264843016984404 24.525265248665356 9.942827244133342 60.200766666666674 39.929 35.4303 39.0725180038775 75.29882612531608 41.26253373334901 16.4324;26.4669;59.5777 10.5224;21.0456;31.0499 39.929;35.4303;105.243 0 3 0 3 24516;24957;25661 JUN_8938;GLUL_32832;FN1_8655 34.159 26.4669 22.577766271932216 20.872633333333333 21.0456 10.264843016984404 60.200766666666674 39.929 39.0725180038775 16.4324;26.4669;59.5777 10.5224;21.0456;31.0499 39.929;35.4303;105.243 0 Linear,1(0.34);Poly 2,1(0.34);Power,1(0.34) 2.0259701312723464 6.120005488395691 1.7792335748672485 2.3622660636901855 0.2963410828563564 1.9785058498382568 8.60985230779098 59.70814769220902 9.256869970404756 32.48839669626191 15.98605024325451 104.41548309007882 DOWN 0.0 1.0 0.0 GO:0070887 4 cellular response to chemical stimulus 594 635 67 66 52 59 46 46 116 589 1796 0.87354 0.16838 0.30215 7.24 79426;286954;246273;24825;170698;83516;29441;24651;25513;81819;25591;24314;81525;25493;24567;24539;89783;58954;24516;81678;192235;63868;24471;81869;294515;314322;25661;361969;24360;24890;29496;25315;116636;24330;140942;25428;25146;497840;113936;29184;25698;65054;25373;170465;312382;25303 zfp36;ugt2b1;trib3;tf;slco1a2;ppargc1a;por;pklr;pik3r1;pax8;parp1;nqo1;nfkbib;nfkbia;mt1;lpl;laptm5;klf6;jun;itpr2;hyou1;hspd1;hspb1;gstm7;foxo3;fos;fn1;fga;fabp1;esr1;erbb3;ephx1;eif4ebp1;egr1;ddit4;cyp7a1;cyp17a1;cps1;cpb2;cd36;ass1;aqp9;ahsg;acaa2;abcg2;abcc2 ZFP36_10204;UGT2B10_33303,UGT2B1_33224;TRIB3_10079;TF_10003;SLCO1A2_9886;PPARGC1A_33189;POR_9531;PKLR_9489;PIK3R1_32562;PAX8_9432;PARP1_9425;NQO1_33055;NFKBIB_9308;NFKBIA_9307;MT1A_9255;LPL_32544;LAPTM5_32639;KLF6_8969;JUN_8938;ITPR2_8931;HYOU1_8857;HSPD1_8849;HSPB1_8847;GSTM7_8761;FOXO3_8662;FOS_8657;FN1_8655;FGA_8632;FABP1_33091;ESR1_33192;ERBB3_8571;EPHX1_8567;EIF4EBP1_8550;EGR1_8533;DDIT4_8450;CYP7A1_8430;CYP17A1_32365;CPS1_32421;CPB2_8369;CD36_8243;ASS1_33159;AQP9_32709;AHSG_8003;ACAA2_7955;ABCG2_32656;ABCC2_32541 37.42625156521741 31.184150000000002 1.28141E-12 28.096578923350304 38.9276420483164 25.05447137039081 25.97278078260872 24.095399999999998 1.28141E-12 19.80998614155208 26.896574086586334 17.059987139221644 63.95841173913047 45.5686 1.28142E-12 50.87528828992998 64.28649739287452 42.564829307860094 30.5 43.78165 0.348134;47.47345;108.064;45.1539;104.197;42.4094;12.4414;23.0963;18.7324;56.8931;26.9741;87.2765;30.5572;0.520151;12.9315;74.2041;38.674;18.9476;16.4324;31.8111;40.1982;42.2579;89.1011;42.3152;13.1992;1.28141E-12;59.5777;28.5803;33.8478;23.3972;60.9984;12.4747;83.9001;0.750017;87.5421;5.72128;49.6922;31.9826;25.8316;48.1296;26.8037;27.7316;12.402;26.5872;5.21654;46.2316 0.118102;34.82915;83.8836;28.132;80.3101;26.2988;8.48981;17.4625;11.6701;45.1162;21.799;60.6992;24.2439;0.160202;8.91033;49.8682;24.6273;11.6941;10.5224;24.7342;29.3844;23.9469;60.3265;31.4035;5.6804;1.28141E-12;31.0499;22.529;26.4736;18.3088;41.6036;7.00435;42.4185;0.186019;53.2453;0.985273;35.6654;24.4836;20.4374;37.5433;20.9825;21.9372;10.3013;21.3695;2.73368;31.1788 1.15962;76.47475;143.428;61.5341;128.412;81.7305;79.2355;32.9443;41.5978;81.5688;35.2797;197.117;41.2611;2.88499;23.4636;155.425;71.0786;45.5481;39.929;44.3296;62.3571;102.383;106.138;64.5991;32.7581;1.28142E-12;105.243;38.8511;46.9257;31.9156;113.972;23.684;107.32;4.70178;245.492;22.3625;81.6409;45.5891;34.8042;69.1421;36.7081;37.4625;15.4235;35.0407;11.386;81.7848 18 29 17 286954;24825;81819;25591;24314;81525;24539;63868;81869;24360;29496;25315;116636;25146;29184;170465;312382 UGT2B10_33303,UGT2B1_33224;TF_10003;PAX8_9432;PARP1_9425;NQO1_33055;NFKBIB_9308;LPL_32544;HSPD1_8849;GSTM7_8761;FABP1_33091;ERBB3_8571;EPHX1_8567;EIF4EBP1_8550;CYP17A1_32365;CD36_8243;ACAA2_7955;ABCG2_32656 45.526587647058825 45.1539 22.688528893258354 31.461763529411762 31.4035 14.646253687754065 76.75023235294117 69.1421 47.98186118550734 47.47345;45.1539;56.8931;26.9741;87.2765;30.5572;74.2041;42.2579;42.3152;33.8478;60.9984;12.4747;83.9001;49.6922;48.1296;26.5872;5.21654 34.82915;28.132;45.1162;21.799;60.6992;24.2439;49.8682;23.9469;31.4035;26.4736;41.6036;7.00435;42.4185;35.6654;37.5433;21.3695;2.73368 76.47475;61.5341;81.5688;35.2797;197.117;41.2611;155.425;102.383;64.5991;46.9257;113.972;23.684;107.32;81.6409;69.1421;35.0407;11.386 29 79426;246273;170698;83516;29441;24651;25513;25493;24567;89783;58954;24516;81678;192235;24471;294515;314322;25661;361969;24890;24330;140942;25428;497840;113936;25698;65054;25373;25303 ZFP36_10204;TRIB3_10079;SLCO1A2_9886;PPARGC1A_33189;POR_9531;PKLR_9489;PIK3R1_32562;NFKBIA_9307;MT1A_9255;LAPTM5_32639;KLF6_8969;JUN_8938;ITPR2_8931;HYOU1_8857;HSPB1_8847;FOXO3_8662;FOS_8657;FN1_8655;FGA_8632;ESR1_33192;EGR1_8533;DDIT4_8450;CYP7A1_8430;CPS1_32421;CPB2_8369;ASS1_33159;AQP9_32709;AHSG_8003;ABCC2_32541 32.67777868965521 25.8316 30.18877199430219 22.755101241379354 20.4374 21.888478389671942 56.45975827586211 39.929 51.832402756204225 0.348134;108.064;104.197;42.4094;12.4414;23.0963;18.7324;0.520151;12.9315;38.674;18.9476;16.4324;31.8111;40.1982;89.1011;13.1992;1.28141E-12;59.5777;28.5803;23.3972;0.750017;87.5421;5.72128;31.9826;25.8316;26.8037;27.7316;12.402;46.2316 0.118102;83.8836;80.3101;26.2988;8.48981;17.4625;11.6701;0.160202;8.91033;24.6273;11.6941;10.5224;24.7342;29.3844;60.3265;5.6804;1.28141E-12;31.0499;22.529;18.3088;0.186019;53.2453;0.985273;24.4836;20.4374;20.9825;21.9372;10.3013;31.1788 1.15962;143.428;128.412;81.7305;79.2355;32.9443;41.5978;2.88499;23.4636;71.0786;45.5481;39.929;44.3296;62.3571;106.138;32.7581;1.28142E-12;105.243;38.8511;31.9156;4.70178;245.492;22.3625;45.5891;34.8042;36.7081;37.4625;15.4235;81.7848 0 Exp 2,20(0.43);Exp 3,2(0.05);Exp 4,3(0.07);Hill,5(0.11);Linear,7(0.15);Poly 2,9(0.2);Power,1(0.03) 1.9376128049019123 94.35617625713348 1.5074360370635986 4.560328960418701 0.6396880535078396 1.8171201944351196 29.30672703208773 45.54577609834707 20.247967490709506 31.69759407450792 49.25615376932372 78.6606697089372 DOWN 0.3695652173913043 0.6304347826086957 0.0 GO:0051704 2 multi-organism process 54 56 7 7 7 7 7 7 155 49 2336 0.9767 0.061586 0.085775 12.5 360268;24471;24384;314322;361969;65210;25303 sult1e1;hspb1;gc;fos;fga;cyp2j4;abcc2 SULT1E1_32446;HSPB1_8847;GC_32893;FOS_8657;FGA_8632;CYP2J4_32580;ABCC2_32541 39.18472857142875 42.356 1.28141E-12 28.213094798793318 41.492236045181656 26.84110958947465 27.36535714285733 26.3722 1.28141E-12 18.794301775879976 29.055111543227603 17.522771783566583 58.44655714285732 78.7583 1.28142E-12 38.347763523698475 60.69307728767522 35.098568735348586 1.5 23.2099 4.5 48.2081 50.1846;89.1011;42.356;1.28141E-12;28.5803;17.8395;46.2316 36.5009;60.3265;26.3722;1.28141E-12;22.529;14.6501;31.1788 80.9788;106.138;78.7583;1.28142E-12;38.8511;22.6149;81.7848 2 5 2 360268;65210 SULT1E1_32446;CYP2J4_32580 34.01205 34.01205 22.871439548157007 25.5755 25.5755 15.450848854351015 51.796850000000006 51.796850000000006 41.26950946649354 50.1846;17.8395 36.5009;14.6501 80.9788;22.6149 5 24471;24384;314322;361969;25303 HSPB1_8847;GC_32893;FOS_8657;FGA_8632;ABCC2_32541 41.253800000000254 42.356 32.31814920311764 28.081300000000255 26.3722 21.631319291018336 61.10644000000026 78.7583 41.82200765677039 89.1011;42.356;1.28141E-12;28.5803;46.2316 60.3265;26.3722;1.28141E-12;22.529;31.1788 106.138;78.7583;1.28142E-12;38.8511;81.7848 0 Exp 2,2(0.29);Exp 3,1(0.15);Hill,1(0.15);Linear,2(0.29);Poly 2,1(0.15) 1.9123020146028267 14.072421550750732 1.5294301509857178 3.8079800605773926 0.8050918827785147 1.7401635646820068 18.28417545656161 60.0852816862959 13.442343544915477 41.28837074079918 30.038136369475694 86.85497791623895 DOWN 0.2857142857142857 0.7142857142857143 0.0 GO:0097176 5 epoxide metabolic process 2 2 2 2 2 2 2 2 160 0 2385 1.0 0.0040221 0.0040221 100.0 65030;25315 ephx2;ephx1 EPHX2_33282;EPHX1_8567 25.602 25.602 12.4747 18.564805697340336 23.54894284760845 18.336355233198017 18.107025 18.107025 7.00435 15.70155356362071 16.37061109010011 15.508337041032563 40.44765 40.44765 23.684 23.707381184875732 37.825882269187986 23.415648412468645 0.0 12.4747 0.0 12.4747 38.7293;12.4747 29.2097;7.00435 57.2113;23.684 2 0 2 65030;25315 EPHX2_33282;EPHX1_8567 25.602 25.602 18.564805697340336 18.107025 18.107025 15.70155356362071 40.44765 40.44765 23.707381184875732 38.7293;12.4747 29.2097;7.00435 57.2113;23.684 0 0 Hill,1(0.5);Linear,1(0.5) 3.369494164895231 7.088274717330933 2.4453113079071045 4.642963409423828 1.5539747036713423 3.5441373586654663 -0.12750799999999884 51.331508 -3.654218 39.868268 7.590896000000008 73.304404 UP 1.0 0.0 0.0 GO:0050729 7 positive regulation of inflammatory response 47 52 4 4 4 4 4 4 158 48 2337 0.767 0.42406 0.56993 7.69 25493;24539;63868;25423 nfkbia;lpl;hspd1;ctsc NFKBIA_9307;LPL_32544;HSPD1_8849;CTSC_32456 43.30518775 49.24825 0.520151 31.377657188896897 56.311505252165944 21.180491827578937 28.0608505 31.107499999999998 0.160202 21.409648992976685 36.85055593918694 15.41823736771246 90.89524750000001 102.63550000000001 2.88499 63.73300807000788 116.78829732006 42.67843414133958 1.5 49.24825 0.520151;74.2041;42.2579;56.2386 0.160202;49.8682;23.9469;38.2681 2.88499;155.425;102.383;102.888 2 2 2 24539;63868 LPL_32544;HSPD1_8849 58.230999999999995 58.230999999999995 22.589374653141707 36.90755 36.90755 18.32912700717086 128.904 128.904 37.506357887696986 74.2041;42.2579 49.8682;23.9469 155.425;102.383 2 25493;25423 NFKBIA_9307;CTSC_32456 28.3793755 28.3793755 39.398893125096805 19.214150999999998 19.214150999999998 26.946353092565275 52.886495000000004 52.886495000000004 70.71280651006612 0.520151;56.2386 0.160202;38.2681 2.88499;102.888 0 Exp 2,2(0.5);Exp 3,1(0.25);Exp 4,1(0.25) 1.7892192723051088 7.239497065544128 1.559399127960205 2.2518506050109863 0.32449339544463285 1.7141236662864685 12.555083704881035 74.05529179511896 7.079394486882848 49.042306513117154 28.43689959139226 153.35359540860776 CONFLICT 0.5 0.5 0.0 GO:0006954 5 inflammatory response 129 140 16 16 11 15 11 11 151 129 2256 0.82471 0.27441 0.47347 7.86 24825;24648;288001;54404;24464;25661;361969;65030;25698;25373;25303 tf;serpina1;kng1;itih4;hp;fn1;fga;ephx2;ass1;ahsg;abcc2 TF_10003;SERPINA1_9807;KNG1L1_34113;ITIH4_32725;HP_8823;FN1_8655;FGA_8632;EPHX2_33282;ASS1_33159;AHSG_8003;ABCC2_32541 38.153254545454544 38.7293 12.402 17.954396414269336 44.046068592827034 16.882112208817826 26.1077 28.132 10.3013 9.954244970965894 29.132359806026038 9.060908249456103 62.46727272727273 57.2113 15.4235 39.27168194035216 74.25991463892326 38.83612966730946 6.0 45.1539 45.1539;15.797;24.3655;57.1163;64.9285;59.5777;28.5803;38.7293;26.8037;12.402;46.2316 28.132;13.013;19.538;39.6402;41.6103;31.0499;22.529;29.2097;20.9825;10.3013;31.1788 61.5341;19.9134;32.1467;101.869;136.455;105.243;38.8511;57.2113;36.7081;15.4235;81.7848 2 9 2 24825;65030 TF_10003;EPHX2_33282 41.9416 41.9416 4.542878226411107 28.67085 28.67085 0.7620489780846986 59.3727 59.3727 3.0566811937132714 45.1539;38.7293 28.132;29.2097 61.5341;57.2113 9 24648;288001;54404;24464;25661;361969;25698;25373;25303 SERPINA1_9807;KNG1L1_34113;ITIH4_32725;HP_8823;FN1_8655;FGA_8632;ASS1_33159;AHSG_8003;ABCC2_32541 37.3114 28.5803 19.899384943949908 25.53811111111111 22.529 11.035340113748697 63.15495555555555 38.8511 43.86042891169418 15.797;24.3655;57.1163;64.9285;59.5777;28.5803;26.8037;12.402;46.2316 13.013;19.538;39.6402;41.6103;31.0499;22.529;20.9825;10.3013;31.1788 19.9134;32.1467;101.869;136.455;105.243;38.8511;36.7081;15.4235;81.7848 0 Exp 2,5(0.46);Linear,4(0.37);Poly 2,1(0.1);Power,1(0.1) 2.059215760640689 24.207560062408447 1.5197933912277222 4.642963409423828 0.9751246144874338 1.8344712257385254 27.54288430571544 48.76362478519365 20.225117140513355 31.990282859486655 39.25919178096765 85.6753536735778 DOWN 0.18181818181818182 0.8181818181818182 0.0 GO:0016052 5 carbohydrate catabolic process 24 30 3 3 3 2 2 2 160 28 2357 0.70272 0.57847 0.7161 6.67 24651;114860 pklr;gale PKLR_9489;GALE_8680 47.12215 47.12215 23.0963 33.97768291754162 40.93110773893431 32.83024410339341 30.3732 30.3732 17.4625 18.258487039730323 27.04633791936848 17.641891235718237 60.9238 60.9238 32.9443 39.56898836841802 53.71397113053284 38.232729118465976 0.5 47.12215 23.0963;71.148 17.4625;43.2839 32.9443;88.9033 0 2 0 2 24651;114860 PKLR_9489;GALE_8680 47.12215 47.12215 33.97768291754162 30.3732 30.3732 18.258487039730323 60.9238 60.9238 39.56898836841802 23.0963;71.148 17.4625;43.2839 32.9443;88.9033 0 Exp 2,1(0.5);Poly 2,1(0.5) 2.2329374109843423 4.54565167427063 1.8488826751708984 2.6967689990997314 0.5995461693254115 2.272825837135315 0.03148399999999896 94.212816 5.068228000000001 55.678172 6.083979999999997 115.76362 DOWN 0.0 1.0 0.0 GO:0045600 7 positive regulation of fat cell differentiation 16 17 3 3 3 3 3 3 159 14 2371 0.98046 0.089037 0.089037 17.65 79426;360268;24539 zfp36;sult1e1;lpl ZFP36_10204;SULT1E1_32446;LPL_32544 41.578944666666665 50.1846 0.348134 37.672521899063064 56.504413549865234 31.354237084620557 28.82906733333333 36.5009 0.118102 25.74705468789395 38.740959170966505 20.936193616085017 79.18780666666667 80.9788 1.15962 77.14828325683038 111.58922520985755 68.84925752779289 0.0 0.348134 0.5 25.266367000000002 0.348134;50.1846;74.2041 0.118102;36.5009;49.8682 1.15962;80.9788;155.425 2 1 2 360268;24539 SULT1E1_32446;LPL_32544 62.19435 62.19435 16.984351330710293 43.18455 43.18455 9.452108476154955 118.20190000000001 118.20190000000001 52.641412853569946 50.1846;74.2041 36.5009;49.8682 80.9788;155.425 1 79426 ZFP36_10204 0.348134 0.348134 0.118102 0.118102 1.15962 1.15962 0.348134 0.118102 1.15962 0 Exp 2,2(0.67);Hill,1(0.34) 1.7390559776971952 5.237739205360413 1.559399127960205 1.9381765127182007 0.18945413533686778 1.7401635646820068 -1.0515270259065304 84.20941635923987 -0.3064678182620071 57.964602484928676 -8.11369426079645 166.48930759412977 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0009410 4 response to xenobiotic stimulus 123 132 18 18 15 16 13 13 149 119 2266 0.96236 0.072505 0.098227 9.85 83516;25513;63868;81869;294515;361969;116636;24330;140942;497840;25698;312382;25303 ppargc1a;pik3r1;hspd1;gstm7;foxo3;fga;eif4ebp1;egr1;ddit4;cps1;ass1;abcg2;abcc2 PPARGC1A_33189;PIK3R1_32562;HSPD1_8849;GSTM7_8761;FOXO3_8662;FGA_8632;EIF4EBP1_8550;EGR1_8533;DDIT4_8450;CPS1_32421;ASS1_33159;ABCG2_32656;ABCC2_32541 36.147773615384615 31.9826 0.750017 26.36210264006464 33.65461457259283 24.832326424192505 22.827469153846152 23.9469 0.186019 15.293760920888054 21.486162162720092 13.936211390896085 68.83856769230769 45.5891 4.70178 61.97755118944199 58.301550285606375 47.7817649415097 5.5 30.28145 42.4094;18.7324;42.2579;42.3152;13.1992;28.5803;83.9001;0.750017;87.5421;31.9826;26.8037;5.21654;46.2316 26.2988;11.6701;23.9469;31.4035;5.6804;22.529;42.4185;0.186019;53.2453;24.4836;20.9825;2.73368;31.1788 81.7305;41.5978;102.383;64.5991;32.7581;38.8511;107.32;4.70178;245.492;45.5891;36.7081;11.386;81.7848 4 9 4 63868;81869;116636;312382 HSPD1_8849;GSTM7_8761;EIF4EBP1_8550;ABCG2_32656 43.42243499999999 42.28655 32.14920365895399 25.125645 27.6752 16.745584828926305 71.42202499999999 83.49105 44.34006158997189 42.2579;42.3152;83.9001;5.21654 23.9469;31.4035;42.4185;2.73368 102.383;64.5991;107.32;11.386 9 83516;25513;294515;361969;24330;140942;497840;25698;25303 PPARGC1A_33189;PIK3R1_32562;FOXO3_8662;FGA_8632;EGR1_8533;DDIT4_8450;CPS1_32421;ASS1_33159;ABCC2_32541 32.914590777777775 28.5803 24.832054750747883 21.806057666666668 22.529 15.552450215964488 67.69036444444446 41.5978 70.85012057941663 42.4094;18.7324;13.1992;28.5803;0.750017;87.5421;31.9826;26.8037;46.2316 26.2988;11.6701;5.6804;22.529;0.186019;53.2453;24.4836;20.9825;31.1788 81.7305;41.5978;32.7581;38.8511;4.70178;245.492;45.5891;36.7081;81.7848 0 Exp 2,4(0.31);Exp 3,2(0.16);Exp 4,2(0.16);Hill,1(0.08);Linear,3(0.24);Poly 2,1(0.08) 1.893661889571744 25.59610605239868 1.5074360370635986 4.21828556060791 0.7031972312548674 1.7576230764389038 21.817171378178195 50.478375852591036 14.513686013684573 31.14125229400773 35.14718708209189 102.5299483025235 DOWN 0.3076923076923077 0.6923076923076923 0.0 GO:0015694 8 mercury ion transport 1 1 1 1 1 1 1 1 161 0 2385 1.0 0.063604 0.063604 100.0 25303 abcc2 ABCC2_32541 46.2316 46.2316 46.2316 46.2316 31.1788 31.1788 31.1788 31.1788 81.7848 81.7848 81.7848 81.7848 0.0 46.2316 0.0 46.2316 46.2316 31.1788 81.7848 0 1 0 1 25303 ABCC2_32541 46.2316 46.2316 31.1788 31.1788 81.7848 81.7848 46.2316 31.1788 81.7848 0 Exp 2,1(1) 1.8589661121368408 1.8589661121368408 1.8589661121368408 1.8589661121368408 0.0 1.8589661121368408 46.2316 46.2316 31.1788 31.1788 81.7848 81.7848 DOWN 0.0 1.0 0.0 GO:0071716 8 leukotriene transport 1 1 1 1 1 1 1 1 161 0 2385 1.0 0.063604 0.063604 100.0 25303 abcc2 ABCC2_32541 46.2316 46.2316 46.2316 46.2316 31.1788 31.1788 31.1788 31.1788 81.7848 81.7848 81.7848 81.7848 0.0 46.2316 0.0 46.2316 46.2316 31.1788 81.7848 0 1 0 1 25303 ABCC2_32541 46.2316 46.2316 31.1788 31.1788 81.7848 81.7848 46.2316 31.1788 81.7848 0 Exp 2,1(1) 1.8589661121368408 1.8589661121368408 1.8589661121368408 1.8589661121368408 0.0 1.8589661121368408 46.2316 46.2316 31.1788 31.1788 81.7848 81.7848 DOWN 0.0 1.0 0.0 GO:0031641 5 regulation of myelination 19 21 2 2 2 2 2 2 160 19 2366 0.85485 0.39001 0.39001 9.52 24825;25423 tf;ctsc TF_10003;CTSC_32456 50.69625 50.69625 45.1539 7.838066537418538 50.968960439037645 7.828572352471417 33.20005 33.20005 28.132 7.167305044784996 33.44942258393367 7.158623347667108 82.21105 82.21105 61.5341 29.241623118510365 83.22845599429115 29.206202983108927 0.5 50.69625 45.1539;56.2386 28.132;38.2681 61.5341;102.888 1 1 1 24825 TF_10003 45.1539 45.1539 28.132 28.132 61.5341 61.5341 45.1539 28.132 61.5341 1 25423 CTSC_32456 56.2386 56.2386 38.2681 38.2681 102.888 102.888 56.2386 38.2681 102.888 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.6990584057551545 3.408112406730652 1.5736411809921265 1.8344712257385254 0.1844346933773693 1.704056203365326 39.833244 61.559256 23.266672 43.133427999999995 41.684228000000004 122.737872 CONFLICT 0.5 0.5 0.0 GO:0007167 6 enzyme linked receptor protein signaling pathway 141 148 13 13 12 13 12 12 150 136 2249 0.85734 0.22786 0.38289 8.11 25513;25591;24516;25685;24471;29455;294515;314322;29496;116636;24330;140942 pik3r1;parp1;jun;igfbp1;hspb1;gdf15;foxo3;fos;erbb3;eif4ebp1;egr1;ddit4 PIK3R1_32562;PARP1_9425;JUN_8938;IGFBP1_32306;HSPB1_8847;GDF15_33113;FOXO3_8662;FOS_8657;ERBB3_8571;EIF4EBP1_8550;EGR1_8533;DDIT4_8450 45.98372641666678 38.0 1.28141E-12 38.104856362549704 52.21990717317109 39.30000767524362 30.45740158333344 27.24365 1.28141E-12 26.934319350508684 35.55589013177961 28.544658842568055 78.50022333333344 65.38005 1.28142E-12 68.42001000863553 77.3197928253553 57.20331203713424 6.5 55.01215 18.7324;26.9741;16.4324;49.0259;89.1011;105.149;13.1992;1.28141E-12;60.9984;83.9001;0.750017;87.5421 11.6701;21.799;10.5224;32.6883;60.3265;85.3487;5.6804;1.28141E-12;41.6036;42.4185;0.186019;53.2453 41.5978;35.2797;39.929;89.1623;106.138;125.652;32.7581;1.28142E-12;113.972;107.32;4.70178;245.492 3 9 3 25591;29496;116636 PARP1_9425;ERBB3_8571;EIF4EBP1_8550 57.29086666666666 60.9984 28.6435284412262 35.2737 41.6036 11.676543605451053 85.52389999999998 107.32 43.63968378929894 26.9741;60.9984;83.9001 21.799;41.6036;42.4185 35.2797;113.972;107.32 9 25513;24516;25685;24471;29455;294515;314322;24330;140942 PIK3R1_32562;JUN_8938;IGFBP1_32306;HSPB1_8847;GDF15_33113;FOXO3_8662;FOS_8657;EGR1_8533;DDIT4_8450 42.21467966666681 18.7324 41.562410506455016 28.85196877777792 11.6701 30.85158603040837 76.15899777777793 41.5978 77.04552495705715 18.7324;16.4324;49.0259;89.1011;105.149;13.1992;1.28141E-12;0.750017;87.5421 11.6701;10.5224;32.6883;60.3265;85.3487;5.6804;1.28141E-12;0.186019;53.2453 41.5978;39.929;89.1623;106.138;125.652;32.7581;1.28142E-12;4.70178;245.492 0 Exp 2,2(0.17);Exp 3,1(0.09);Exp 4,1(0.09);Hill,2(0.17);Linear,2(0.17);Poly 2,4(0.34) 2.014196904914063 25.719563961029053 1.5606178045272827 4.21828556060791 0.9203240270436117 1.752993643283844 24.423874319883673 67.54357851344986 15.217875786427015 45.69692738023987 39.78795836081969 117.21248830584722 DOWN 0.25 0.75 0.0 GO:0097306 6 cellular response to alcohol 47 52 7 7 7 6 6 6 156 46 2339 0.95613 0.10904 0.14069 11.54 286954;58954;81678;294515;25661;25428 ugt2b1;klf6;itpr2;foxo3;fn1;cyp7a1 UGT2B10_33303,UGT2B1_33224;KLF6_8969;ITPR2_8931;FOXO3_8662;FN1_8655;CYP7A1_8430 29.455055 25.379350000000002 5.72128 20.85923659352254 41.113028124059156 18.094853067477597 18.162170500000002 18.21415 0.985273 13.99821194010583 26.03662644517901 10.578353841149283 54.452675 44.93885 22.3625 30.811786446938605 70.08234438055774 30.352965077888364 1.5 16.0734 4.5 53.525575 47.47345;18.9476;31.8111;13.1992;59.5777;5.72128 34.82915;11.6941;24.7342;5.6804;31.0499;0.985273 76.47475;45.5481;44.3296;32.7581;105.243;22.3625 2 5 1 286954 UGT2B10_33303,UGT2B1_33224 47.47345 47.47345 34.82915 34.82915 76.47475 76.47475 47.47345 34.82915 76.47475 5 58954;81678;294515;25661;25428 KLF6_8969;ITPR2_8931;FOXO3_8662;FN1_8655;CYP7A1_8430 25.851376 18.9476 21.130213476628203 14.828774600000003 11.6941 12.712236632635728 50.04826 44.3296 32.2678817692299 18.9476;31.8111;13.1992;59.5777;5.72128 11.6941;24.7342;5.6804;31.0499;0.985273 45.5481;44.3296;32.7581;105.243;22.3625 0 Exp 2,2(0.29);Exp 4,1(0.15);Hill,1(0.15);Linear,1(0.15);Poly 2,1(0.15);Power,1(0.15) 1.989289270469498 14.98445177078247 1.5740432739257812 4.560328960418701 1.07528255714657 1.7730062007904053 12.76418954781381 46.14592045218619 6.961268155565877 29.36307284443412 29.798111079523384 79.10723892047662 DOWN 0.16666666666666666 0.8333333333333334 0.0 GO:0055086 5 nucleobase-containing small molecule metabolic process 108 122 26 26 17 23 15 15 147 107 2278 0.99626 0.0090898 0.011706 12.3 24856;360268;298490;24651;294103;100359982;25675;83842;497840;25028;192272;170570;50559;170465;296925 ttr;sult1e1;ppcs;pklr;papss2;mpc2;hmgcr;crot;cps1;ampd1;acot2;acot12;acot1;acaa2;aass TTR_10102;SULT1E1_32446;PPCS_9540;PKLR_9489;PAPSS2_33237;MPC2_33219;HMGCR_8810;CROT_8384;CPS1_32421;AMPD1_32743;ACOT2_7969;ACOT12_32718;ACOT1_7968;ACAA2_7955;AASS_7936 29.84220266666666 30.3423 1.63089 16.651690520674503 33.907922991080966 14.00935269928419 22.869371133333335 24.0157 0.663137 12.694331167187439 26.135249854758598 10.68164072340975 42.039366666666666 37.2719 7.6286 24.05923286259698 46.77362846213415 20.759132489471654 5.5 27.0258 11.5 46.743449999999996 46.6406;50.1846;20.3353;23.0963;34.4443;46.8463;1.63089;7.4229;31.9826;60.9045;8.54905;30.3423;31.2018;26.5872;27.4644 28.5876;36.5009;16.7643;17.4625;25.719;35.8494;0.663137;5.75707;24.4836;50.0633;7.19676;24.0157;26.858;21.3695;21.7498 63.7146;80.9788;25.6711;32.9443;51.1014;69.127;7.6286;10.316;45.5891;82.6625;10.4125;41.1025;37.2719;35.0407;37.0295 11 4 11 24856;360268;298490;100359982;83842;25028;192272;170570;50559;170465;296925 TTR_10102;SULT1E1_32446;PPCS_9540;MPC2_33219;CROT_8384;AMPD1_32743;ACOT2_7969;ACOT12_32718;ACOT1_7968;ACAA2_7955;AASS_7936 32.40717727272727 30.3423 17.15338786638611 24.973848181818184 24.0157 12.939282605612117 44.84791818181819 37.2719 25.79834078043849 46.6406;50.1846;20.3353;46.8463;7.4229;60.9045;8.54905;30.3423;31.2018;26.5872;27.4644 28.5876;36.5009;16.7643;35.8494;5.75707;50.0633;7.19676;24.0157;26.858;21.3695;21.7498 63.7146;80.9788;25.6711;69.127;10.316;82.6625;10.4125;41.1025;37.2719;35.0407;37.0295 4 24651;294103;25675;497840 PKLR_9489;PAPSS2_33237;HMGCR_8810;CPS1_32421 22.7885225 27.539450000000002 14.923453020889358 17.08205925 20.97305 11.53408418570408 34.31585 39.2667 19.347104144462218 23.0963;34.4443;1.63089;31.9826 17.4625;25.719;0.663137;24.4836 32.9443;51.1014;7.6286;45.5891 0 Exp 2,10(0.67);Exp 4,1(0.07);Linear,2(0.14);Poly 2,2(0.14) 3.3959207271503984 386.175555229187 1.571676254272461 344.14306640625 88.12275594534663 1.9248499870300293 21.41528457715776 38.26912075617557 16.445153194970196 29.293589071696466 29.863714928616396 54.215018404716936 UP 0.7333333333333333 0.26666666666666666 0.0 GO:0010468 6 regulation of gene expression 723 775 58 58 45 50 40 40 122 735 1650 0.058459 0.96004 0.11214 5.16 79426;24522;308843;246273;24825;170698;29573;293615;83516;25513;81819;25591;81525;25493;24539;58954;24516;494344;63868;24471;290556;25112;294515;314322;25661;308441;24890;29496;65030;116636;24330;25428;65210;113936;25695;114851;29184;79431;155423;25303 zfp36;zfp354a;tsku;trib3;tf;slco1a2;slc37a4;sirt3;ppargc1a;pik3r1;pax8;parp1;nfkbib;nfkbia;lpl;klf6;jun;ier2;hspd1;hspb1;gnl3;gadd45a;foxo3;fos;fn1;exosc5;esr1;erbb3;ephx2;eif4ebp1;egr1;cyp7a1;cyp2j4;cpb2;cebpd;cdkn1a;cd36;bhlhe40;anxa7;abcc2 ZFP36_10204;ZFP354A_10203;TSKU_10094;TRIB3_10079;TF_10003;SLCO1A2_9886;SLC37A4_9871;SIRT3_9828;PPARGC1A_33189;PIK3R1_32562;PAX8_9432;PARP1_9425;NFKBIB_9308;NFKBIA_9307;LPL_32544;KLF6_8969;JUN_8938;IER2_32643;HSPD1_8849;HSPB1_8847;GNL3_8735;GADD45A_8678;FOXO3_8662;FOS_8657;FN1_8655;EXOSC5_32543;ESR1_33192;ERBB3_8571;EPHX2_33282;EIF4EBP1_8550;EGR1_8533;CYP7A1_8430;CYP2J4_32580;CPB2_8369;CEBPD_8283;CDKN1A_8271;CD36_8243;BHLHE40_8141;ANXA7_8051;ABCC2_32541 39.86469637500004 39.22295 1.28141E-12 33.71559400112179 42.73192823963264 32.287828463361244 26.732549705000036 24.095399999999998 1.28141E-12 23.920253276003436 28.763242027678405 23.26937757375892 64.35310100000004 58.62235 1.28142E-12 52.588454123490216 66.44319519715872 46.4959678202518 37.5 104.4185 0.348134;0.834827;1.38416;108.064;45.1539;104.197;39.7166;2.38018;42.4094;18.7324;56.8931;26.9741;30.5572;0.520151;74.2041;18.9476;16.4324;49.6814;42.2579;89.1011;87.6357;102.919;13.1992;1.28141E-12;59.5777;41.9329;23.3972;60.9984;38.7293;83.9001;0.750017;5.72128;17.8395;25.8316;0.306936;6.24967;48.1296;57.8085;104.64;46.2316 0.118102;0.27095;0.540568;83.8836;28.132;80.3101;22.6911;0.56209;26.2988;11.6701;45.1162;21.799;24.2439;0.160202;49.8682;11.6941;10.5224;33.4626;23.9469;60.3265;54.41;89.5012;5.6804;1.28141E-12;31.0499;31.7336;18.3088;41.6036;29.2097;42.4185;0.186019;0.985273;14.6501;20.4374;0.0732342;2.44025;37.5433;38.3491;43.9254;31.1788 1.15962;2.99857;4.10872;143.428;61.5341;128.412;60.0334;8.82917;81.7305;41.5978;81.5688;35.2797;41.2611;2.88499;155.425;45.5481;39.929;89.4404;102.383;106.138;238.963;115.437;32.7581;1.28142E-12;105.243;62.1373;31.9156;113.972;57.2113;107.32;4.70178;22.3625;22.6149;34.8042;1.73689;19.0606;69.1421;110.58;108.689;81.7848 15 25 15 24825;293615;81819;25591;81525;24539;63868;290556;308441;29496;65030;116636;65210;29184;155423 TF_10003;SIRT3_9828;PAX8_9432;PARP1_9425;NFKBIB_9308;LPL_32544;HSPD1_8849;GNL3_8735;EXOSC5_32543;ERBB3_8571;EPHX2_33282;EIF4EBP1_8550;CYP2J4_32580;CD36_8243;ANXA7_8051 50.81506533333333 45.1539 27.7549673075809 32.61083266666667 31.7336 14.399616886739159 84.42203133333334 69.1421 57.97048325850477 45.1539;2.38018;56.8931;26.9741;30.5572;74.2041;42.2579;87.6357;41.9329;60.9984;38.7293;83.9001;17.8395;48.1296;104.64 28.132;0.56209;45.1162;21.799;24.2439;49.8682;23.9469;54.41;31.7336;41.6036;29.2097;42.4185;14.6501;37.5433;43.9254 61.5341;8.82917;81.5688;35.2797;41.2611;155.425;102.383;238.963;62.1373;113.972;57.2113;107.32;22.6149;69.1421;108.689 25 79426;24522;308843;246273;170698;29573;83516;25513;25493;58954;24516;494344;24471;25112;294515;314322;25661;24890;24330;25428;113936;25695;114851;79431;25303 ZFP36_10204;ZFP354A_10203;TSKU_10094;TRIB3_10079;SLCO1A2_9886;SLC37A4_9871;PPARGC1A_33189;PIK3R1_32562;NFKBIA_9307;KLF6_8969;JUN_8938;IER2_32643;HSPB1_8847;GADD45A_8678;FOXO3_8662;FOS_8657;FN1_8655;ESR1_33192;EGR1_8533;CYP7A1_8430;CPB2_8369;CEBPD_8283;CDKN1A_8271;BHLHE40_8141;ABCC2_32541 33.29447500000005 18.9476 35.74814739016512 23.205579928000052 11.6941 27.825928833023557 52.31174280000005 39.929 46.161812597244264 0.348134;0.834827;1.38416;108.064;104.197;39.7166;42.4094;18.7324;0.520151;18.9476;16.4324;49.6814;89.1011;102.919;13.1992;1.28141E-12;59.5777;23.3972;0.750017;5.72128;25.8316;0.306936;6.24967;57.8085;46.2316 0.118102;0.27095;0.540568;83.8836;80.3101;22.6911;26.2988;11.6701;0.160202;11.6941;10.5224;33.4626;60.3265;89.5012;5.6804;1.28141E-12;31.0499;18.3088;0.186019;0.985273;20.4374;0.0732342;2.44025;38.3491;31.1788 1.15962;2.99857;4.10872;143.428;128.412;60.0334;81.7305;41.5978;2.88499;45.5481;39.929;89.4404;106.138;115.437;32.7581;1.28142E-12;105.243;31.9156;4.70178;22.3625;34.8042;1.73689;19.0606;110.58;81.7848 0 Exp 2,13(0.33);Exp 3,3(0.08);Exp 4,3(0.08);Hill,8(0.2);Linear,3(0.08);Poly 2,9(0.23);Power,1(0.03) 2.000970318777969 85.32536089420319 1.5209722518920898 4.642963409423828 0.9135579899034786 1.772010862827301 29.416125543512674 50.31326720648735 19.31958641409306 34.14551299590699 48.05577022156478 80.65043177843532 DOWN 0.375 0.625 0.0 GO:0010942 6 positive regulation of cell death 222 238 25 25 23 22 20 20 142 218 2167 0.92819 0.11418 0.20729 8.4 24794;83516;25591;24314;24516;63868;24464;25675;299626;25112;289388;294515;314322;24330;116663;140942;25423;114851;29184;246142 serpina3c;ppargc1a;parp1;nqo1;jun;hspd1;hp;hmgcr;gadd45b;gadd45a;g0s2;foxo3;fos;egr1;dusp6;ddit4;ctsc;cdkn1a;cd36;bmf SERPINA3C_32925;PPARGC1A_33189;PARP1_9425;NQO1_33055;JUN_8938;HSPD1_8849;HP_8823;HMGCR_8810;GADD45B_8679;GADD45A_8678;G0S2_32729;FOXO3_8662;FOS_8657;EGR1_8533;DUSP6_8506;DDIT4_8450;CTSC_32456;CDKN1A_8271;CD36_8243;BMF_8152 46.835968850000064 44.3939 1.28141E-12 35.34771868203227 49.28265612856626 33.871440178683805 31.723880300000065 30.0451 1.28141E-12 25.380216821122904 35.337720959655506 27.06522688241875 82.85334400000005 77.6917 1.28142E-12 64.71060950471866 80.14272600551939 51.3594920672475 10.5 47.254000000000005 29.766;42.4094;26.9741;87.2765;16.4324;42.2579;64.9285;1.63089;106.367;102.919;46.3784;13.1992;1.28141E-12;0.750017;62.3934;87.5421;56.2386;6.24967;48.1296;94.8767 23.347;26.2988;21.799;60.6992;10.5224;23.9469;41.6103;0.663137;52.7132;89.5012;33.7914;5.6804;1.28141E-12;0.186019;39.0875;53.2453;38.2681;2.44025;37.5433;73.1342 40.8256;81.7305;35.2797;197.117;39.929;102.383;136.455;7.6286;109.434;115.437;73.6529;32.7581;1.28142E-12;4.70178;133.304;245.492;102.888;19.0606;69.1421;109.848 7 13 7 25591;24314;63868;299626;289388;29184;246142 PARP1_9425;NQO1_33055;HSPD1_8849;GADD45B_8679;G0S2_32729;CD36_8243;BMF_8152 64.6086 48.1296 30.804660232828418 43.37531428571429 37.5433 19.32946295291453 99.55095714285714 102.383 50.75604933486114 26.9741;87.2765;42.2579;106.367;46.3784;48.1296;94.8767 21.799;60.6992;23.9469;52.7132;33.7914;37.5433;73.1342 35.2797;197.117;102.383;109.434;73.6529;69.1421;109.848 13 24794;83516;24516;24464;25675;25112;294515;314322;24330;116663;140942;25423;114851 SERPINA3C_32925;PPARGC1A_33189;JUN_8938;HP_8823;HMGCR_8810;GADD45A_8678;FOXO3_8662;FOS_8657;EGR1_8533;DUSP6_8506;DDIT4_8450;CTSC_32456;CDKN1A_8271 37.26609053846163 29.766 34.93394028313848 25.45003123076933 23.347 26.66957867158585 73.86232153846164 40.8256 71.35717968200781 29.766;42.4094;16.4324;64.9285;1.63089;102.919;13.1992;1.28141E-12;0.750017;62.3934;87.5421;56.2386;6.24967 23.347;26.2988;10.5224;41.6103;0.663137;89.5012;5.6804;1.28141E-12;0.186019;39.0875;53.2453;38.2681;2.44025 40.8256;81.7305;39.929;136.455;7.6286;115.437;32.7581;1.28142E-12;4.70178;133.304;245.492;102.888;19.0606 0 Exp 2,7(0.35);Exp 3,1(0.05);Exp 4,3(0.15);Hill,2(0.1);Linear,3(0.15);Poly 2,3(0.15);Power,1(0.05) 1.8810575039185833 38.87434220314026 1.522104263305664 4.21828556060791 0.6114008622997079 1.729400396347046 31.344148092777637 62.32778960722249 20.60050984124004 42.84725075876009 54.49266894327309 111.21401905672707 DOWN 0.35 0.65 0.0 GO:0010557 7 positive regulation of macromolecule biosynthetic process 371 401 28 28 22 22 18 18 144 383 2002 0.054837 0.96735 0.1176 4.49 24825;293615;83516;303612;25513;81819;25591;25493;58954;24516;494344;24471;290556;294515;314322;24890;24330;25695 tf;sirt3;ppargc1a;polg2;pik3r1;pax8;parp1;nfkbia;klf6;jun;ier2;hspb1;gnl3;foxo3;fos;esr1;egr1;cebpd TF_10003;SIRT3_9828;PPARGC1A_33189;POLG2_9521;PIK3R1_32562;PAX8_9432;PARP1_9425;NFKBIA_9307;KLF6_8969;JUN_8938;IER2_32643;HSPB1_8847;GNL3_8735;FOXO3_8662;FOS_8657;ESR1_33192;EGR1_8533;CEBPD_8283 30.90503244444452 21.172400000000003 1.28141E-12 29.17742366070298 34.3431354990204 28.238280664571178 20.519874733333406 15.001450000000002 1.28141E-12 19.648186913861736 23.44894688218275 19.614286714567275 57.617940555555634 40.763400000000004 1.28142E-12 59.484142807314 56.484302785829954 45.42865871263924 45.1539;2.38018;42.4094;63.7758;18.7324;56.8931;26.9741;0.520151;18.9476;16.4324;49.6814;89.1011;87.6357;13.1992;1.28141E-12;23.3972;0.750017;0.306936 28.132;0.56209;26.2988;40.9553;11.6701;45.1162;21.799;0.160202;11.6941;10.5224;33.4626;60.3265;54.41;5.6804;1.28141E-12;18.3088;0.186019;0.0732342 61.5341;8.82917;81.7305;132.567;41.5978;81.5688;35.2797;2.88499;45.5481;39.929;89.4404;106.138;238.963;32.7581;1.28142E-12;31.9156;4.70178;1.73689 5 13 5 24825;293615;81819;25591;290556 TF_10003;SIRT3_9828;PAX8_9432;PARP1_9425;GNL3_8735 43.807396 45.1539 31.99040103471791 30.003858 28.132 20.98620915141226 85.23495399999999 61.5341 90.19541912331013 45.1539;2.38018;56.8931;26.9741;87.6357 28.132;0.56209;45.1162;21.799;54.41 61.5341;8.82917;81.5688;35.2797;238.963 13 83516;303612;25513;25493;58954;24516;494344;24471;294515;314322;24890;24330;25695 PPARGC1A_33189;POLG2_9521;PIK3R1_32562;NFKBIA_9307;KLF6_8969;JUN_8938;IER2_32643;HSPB1_8847;FOXO3_8662;FOS_8657;ESR1_33192;EGR1_8533;CEBPD_8283 25.942584923077018 18.7324 27.728505797009337 16.87218886153856 11.6701 18.66030698877674 46.9960123076924 39.929 43.13843396211831 42.4094;63.7758;18.7324;0.520151;18.9476;16.4324;49.6814;89.1011;13.1992;1.28141E-12;23.3972;0.750017;0.306936 26.2988;40.9553;11.6701;0.160202;11.6941;10.5224;33.4626;60.3265;5.6804;1.28141E-12;18.3088;0.186019;0.0732342 81.7305;132.567;41.5978;2.88499;45.5481;39.929;89.4404;106.138;32.7581;1.28142E-12;31.9156;4.70178;1.73689 0 Exp 2,7(0.39);Exp 4,2(0.12);Hill,4(0.23);Poly 2,5(0.28) 1.8580580118124963 34.51774823665619 1.5209722518920898 4.21828556060791 0.6128830120518789 1.7612056136131287 17.425750414127727 44.38431447476131 11.442875479522625 29.596873987144185 30.13766859750342 85.09821251360783 DOWN 0.2777777777777778 0.7222222222222222 0.0 GO:0008285 6 negative regulation of cell population proliferation 190 199 12 12 10 9 8 8 154 191 2194 0.099254 0.9484 0.17547 4.02 24794;25106;83516;25513;24516;24890;113936;114851 serpina3c;rgn;ppargc1a;pik3r1;jun;esr1;cpb2;cdkn1a SERPINA3C_32925;RGN_9699;PPARGC1A_33189;PIK3R1_32562;JUN_8938;ESR1_33192;CPB2_8369;CDKN1A_8271 30.03242125 24.614400000000003 6.24967 21.84604852396257 29.986814789594018 25.760294814038254 21.474743750000002 19.3731 2.44025 16.934528580418963 20.7726031051103 20.041202389006887 47.4585 40.377300000000005 19.0606 24.816356785970253 48.90250319162084 29.13993172179585 29.766;77.4407;42.4094;18.7324;16.4324;23.3972;25.8316;6.24967 23.347;58.7732;26.2988;11.6701;10.5224;18.3088;20.4374;2.44025 40.8256;89.8047;81.7305;41.5978;39.929;31.9156;34.8042;19.0606 1 7 1 25106 RGN_9699 77.4407 77.4407 58.7732 58.7732 89.8047 89.8047 77.4407 58.7732 89.8047 7 24794;83516;25513;24516;24890;113936;114851 SERPINA3C_32925;PPARGC1A_33189;PIK3R1_32562;JUN_8938;ESR1_33192;CPB2_8369;CDKN1A_8271 23.259809999999998 23.3972 11.34405950807294 16.14639285714286 18.3088 8.341999224727669 41.409042857142865 39.929 19.4147228171352 29.766;42.4094;18.7324;16.4324;23.3972;25.8316;6.24967 23.347;26.2988;11.6701;10.5224;18.3088;20.4374;2.44025 40.8256;81.7305;41.5978;39.929;31.9156;34.8042;19.0606 0 Exp 2,3(0.38);Exp 4,1(0.13);Linear,1(0.13);Poly 2,3(0.38) 1.7646457031506817 14.271978855133057 1.522104263305664 2.436986207962036 0.2989130236909404 1.696733295917511 14.893881977644197 45.17096052235581 9.739714154496582 33.209773345503415 30.26164211564973 64.65535788435027 DOWN 0.125 0.875 0.0 GO:0048518 4 positive regulation of biological process 1152 1238 99 98 74 84 64 64 98 1174 1211 0.010141 0.99353 0.018352 5.17 79426;246273;24825;360268;362895;29482;293615;24794;246074;25106;83516;29441;303612;298199;85253;25513;81819;25591;24314;25493;100359982;24539;58954;24516;25685;494344;65164;63868;24471;24464;25675;113965;81869;290556;24957;29455;299626;25112;289388;294515;314322;25661;361969;24360;24890;29496;65030;116636;24330;116663;140942;25428;65210;25146;25423;113936;25695;114851;29184;313421;246142;25698;25373;25287 zfp36;trib3;tf;sult1e1;stac3;slc1a2;sirt3;serpina3c;scd;rgn;ppargc1a;por;polg2;plin2;plg;pik3r1;pax8;parp1;nqo1;nfkbia;mpc2;lpl;klf6;jun;igfbp1;ier2;htra1;hspd1;hspb1;hp;hmgcr;hadh;gstm7;gnl3;glul;gdf15;gadd45b;gadd45a;g0s2;foxo3;fos;fn1;fga;fabp1;esr1;erbb3;ephx2;eif4ebp1;egr1;dusp6;ddit4;cyp7a1;cyp2j4;cyp17a1;ctsc;cpb2;cebpd;cdkn1a;cd36;c8b;bmf;ass1;ahsg;acadl ZFP36_10204;TRIB3_10079;TF_10003;SULT1E1_32446;STAC3_9953;SLC1A2_33059;SIRT3_9828;SERPINA3C_32925;SCD1_9787;RGN_9699;PPARGC1A_33189;POR_9531;POLG2_9521;PLIN2_9502;PLG_9501;PIK3R1_32562;PAX8_9432;PARP1_9425;NQO1_33055;NFKBIA_9307;MPC2_33219;LPL_32544;KLF6_8969;JUN_8938;IGFBP1_32306;IER2_32643;HTRA1_8856;HSPD1_8849;HSPB1_8847;HP_8823;HMGCR_8810;HADH_8776;GSTM7_8761;GNL3_8735;GLUL_32832;GDF15_33113;GADD45B_8679;GADD45A_8678;G0S2_32729;FOXO3_8662;FOS_8657;FN1_8655;FGA_8632;FABP1_33091;ESR1_33192;ERBB3_8571;EPHX2_33282;EIF4EBP1_8550;EGR1_8533;DUSP6_8506;DDIT4_8450;CYP7A1_8430;CYP2J4_32580;CYP17A1_32365;CTSC_32456;CPB2_8369;CEBPD_8283;CDKN1A_8271;CD36_8243;C8B_8181;BMF_8152;ASS1_33159;AHSG_8003;ACADL_32776 44.209524343750005 42.28655 1.28141E-12 31.396848071537725 47.60465225144806 30.18203401770378 30.586120893750017 27.36795 1.28141E-12 22.05770458278826 33.489549750367615 22.352361550555916 78.69172578125003 66.86305 1.28142E-12 69.86258760722026 80.08679322045363 60.17487555835137 60.5 105.30449999999999 0.348134;108.064;45.1539;50.1846;63.2393;13.3235;2.38018;29.766;105.46;77.4407;42.4094;12.4414;63.7758;25.6517;70.7857;18.7324;56.8931;26.9741;87.2765;0.520151;46.8463;74.2041;18.9476;16.4324;49.0259;49.6814;33.1323;42.2579;89.1011;64.9285;1.63089;33.3125;42.3152;87.6357;26.4669;105.149;106.367;102.919;46.3784;13.1992;1.28141E-12;59.5777;28.5803;33.8478;23.3972;60.9984;38.7293;83.9001;0.750017;62.3934;87.5421;5.72128;17.8395;49.6922;56.2386;25.8316;0.306936;6.24967;48.1296;21.3618;94.8767;26.8037;12.402;33.4878 0.118102;83.8836;28.132;36.5009;42.7031;9.10952;0.56209;23.347;63.7532;58.7732;26.2988;8.48981;40.9553;20.9252;46.2356;11.6701;45.1162;21.799;60.6992;0.160202;35.8494;49.8682;11.6941;10.5224;32.6883;33.4626;25.6145;23.9469;60.3265;41.6103;0.663137;25.7336;31.4035;54.41;21.0456;85.3487;52.7132;89.5012;33.7914;5.6804;1.28141E-12;31.0499;22.529;26.4736;18.3088;41.6036;29.2097;42.4185;0.186019;39.0875;53.2453;0.985273;14.6501;35.6654;38.2681;20.4374;0.0732342;2.44025;37.5433;17.2088;73.1342;20.9825;10.3013;26.6039 1.15962;143.428;61.5341;80.9788;121.52;24.6773;8.82917;40.8256;422.699;89.8047;81.7305;79.2355;132.567;33.0375;150.579;41.5978;81.5688;35.2797;197.117;2.88499;69.127;155.425;45.5481;39.929;89.1623;89.4404;46.6629;102.383;106.138;136.455;7.6286;46.9856;64.5991;238.963;35.4303;125.652;109.434;115.437;73.6529;32.7581;1.28142E-12;105.243;38.8511;46.9257;31.9156;113.972;57.2113;107.32;4.70178;133.304;245.492;22.3625;22.6149;81.6409;102.888;34.8042;1.73689;19.0606;69.1421;27.9161;109.848;36.7081;15.4235;45.3228 26 38 26 24825;360268;293615;246074;25106;298199;81819;25591;24314;100359982;24539;63868;113965;81869;290556;299626;289388;24360;29496;65030;116636;65210;25146;29184;246142;25287 TF_10003;SULT1E1_32446;SIRT3_9828;SCD1_9787;RGN_9699;PLIN2_9502;PAX8_9432;PARP1_9425;NQO1_33055;MPC2_33219;LPL_32544;HSPD1_8849;HADH_8776;GSTM7_8761;GNL3_8735;GADD45B_8679;G0S2_32729;FABP1_33091;ERBB3_8571;EPHX2_33282;EIF4EBP1_8550;CYP2J4_32580;CYP17A1_32365;CD36_8243;BMF_8152;ACADL_32776 54.547433846153844 47.48795 27.36787543465414 37.356903461538465 35.757400000000004 16.617291463130552 97.13138730769232 77.31585000000001 83.92175942593165 45.1539;50.1846;2.38018;105.46;77.4407;25.6517;56.8931;26.9741;87.2765;46.8463;74.2041;42.2579;33.3125;42.3152;87.6357;106.367;46.3784;33.8478;60.9984;38.7293;83.9001;17.8395;49.6922;48.1296;94.8767;33.4878 28.132;36.5009;0.56209;63.7532;58.7732;20.9252;45.1162;21.799;60.6992;35.8494;49.8682;23.9469;25.7336;31.4035;54.41;52.7132;33.7914;26.4736;41.6036;29.2097;42.4185;14.6501;35.6654;37.5433;73.1342;26.6039 61.5341;80.9788;8.82917;422.699;89.8047;33.0375;81.5688;35.2797;197.117;69.127;155.425;102.383;46.9856;64.5991;238.963;109.434;73.6529;46.9257;113.972;57.2113;107.32;22.6149;81.6409;69.1421;109.848;45.3228 38 79426;246273;362895;29482;24794;83516;29441;303612;85253;25513;25493;58954;24516;25685;494344;65164;24471;24464;25675;24957;29455;25112;294515;314322;25661;361969;24890;24330;116663;140942;25428;25423;113936;25695;114851;313421;25698;25373 ZFP36_10204;TRIB3_10079;STAC3_9953;SLC1A2_33059;SERPINA3C_32925;PPARGC1A_33189;POR_9531;POLG2_9521;PLG_9501;PIK3R1_32562;NFKBIA_9307;KLF6_8969;JUN_8938;IGFBP1_32306;IER2_32643;HTRA1_8856;HSPB1_8847;HP_8823;HMGCR_8810;GLUL_32832;GDF15_33113;GADD45A_8678;FOXO3_8662;FOS_8657;FN1_8655;FGA_8632;ESR1_33192;EGR1_8533;DUSP6_8506;DDIT4_8450;CYP7A1_8430;CTSC_32456;CPB2_8369;CEBPD_8283;CDKN1A_8271;C8B_8181;ASS1_33159;AHSG_8003 37.1362178421053 26.6353 32.3402979440859 25.95348018947372 21.01405 24.240542823352186 66.07511526315794 41.2117 56.11964147161339 0.348134;108.064;63.2393;13.3235;29.766;42.4094;12.4414;63.7758;70.7857;18.7324;0.520151;18.9476;16.4324;49.0259;49.6814;33.1323;89.1011;64.9285;1.63089;26.4669;105.149;102.919;13.1992;1.28141E-12;59.5777;28.5803;23.3972;0.750017;62.3934;87.5421;5.72128;56.2386;25.8316;0.306936;6.24967;21.3618;26.8037;12.402 0.118102;83.8836;42.7031;9.10952;23.347;26.2988;8.48981;40.9553;46.2356;11.6701;0.160202;11.6941;10.5224;32.6883;33.4626;25.6145;60.3265;41.6103;0.663137;21.0456;85.3487;89.5012;5.6804;1.28141E-12;31.0499;22.529;18.3088;0.186019;39.0875;53.2453;0.985273;38.2681;20.4374;0.0732342;2.44025;17.2088;20.9825;10.3013 1.15962;143.428;121.52;24.6773;40.8256;81.7305;79.2355;132.567;150.579;41.5978;2.88499;45.5481;39.929;89.1623;89.4404;46.6629;106.138;136.455;7.6286;35.4303;125.652;115.437;32.7581;1.28142E-12;105.243;38.8511;31.9156;4.70178;133.304;245.492;22.3625;102.888;34.8042;1.73689;19.0606;27.9161;36.7081;15.4235 0 Exp 2,24(0.38);Exp 3,2(0.04);Exp 4,4(0.07);Hill,6(0.1);Linear,14(0.22);Poly 2,12(0.19);Power,2(0.04) 1.9369238479742026 129.8149769306183 1.5122476816177368 4.642963409423828 0.7399153427461295 1.7612056136131287 36.51729656622327 51.90175212127675 25.181983270966892 35.99025851653314 61.57539181748108 95.808059745019 CONFLICT 0.40625 0.59375 0.0 GO:0048732 5 gland development 137 157 24 24 17 19 13 13 149 144 2241 0.87982 0.19433 0.30943 8.28 246074;25106;81819;25493;24516;24464;361969;25315;25146;497840;113936;25698;24158 scd;rgn;pax8;nfkbia;jun;hp;fga;ephx1;cyp17a1;cps1;cpb2;ass1;acadm SCD1_9787;RGN_9699;PAX8_9432;NFKBIA_9307;JUN_8938;HP_8823;FGA_8632;EPHX1_8567;CYP17A1_32365;CPS1_32421;CPB2_8369;ASS1_33159;ACADM_7957 39.13489623076923 28.5803 0.520151 30.165177683302904 41.66328206646955 27.69782419548617 27.646097076923073 22.529 0.160202 20.034053212295174 29.693559738427723 18.71487836585985 81.04485307692309 39.929 2.88499 108.7659285730024 80.67768858251837 96.26342979373223 6.5 30.28145 105.46;77.4407;56.8931;0.520151;16.4324;64.9285;28.5803;12.4747;49.6922;31.9826;25.8316;26.8037;11.7137 63.7532;58.7732;45.1162;0.160202;10.5224;41.6103;22.529;7.00435;35.6654;24.4836;20.4374;20.9825;8.36151 422.699;89.8047;81.5688;2.88499;39.929;136.455;38.8511;23.684;81.6409;45.5891;34.8042;36.7081;18.9642 6 7 6 246074;25106;81819;25315;25146;24158 SCD1_9787;RGN_9699;PAX8_9432;EPHX1_8567;CYP17A1_32365;ACADM_7957 52.279066666666665 53.292649999999995 36.65852485710065 36.44564333333333 40.3908 24.394745617035383 119.72693333333332 81.60485 151.6386334510789 105.46;77.4407;56.8931;12.4747;49.6922;11.7137 63.7532;58.7732;45.1162;7.00435;35.6654;8.36151 422.699;89.8047;81.5688;23.684;81.6409;18.9642 7 25493;24516;24464;361969;497840;113936;25698 NFKBIA_9307;JUN_8938;HP_8823;FGA_8632;CPS1_32421;CPB2_8369;ASS1_33159 27.86846442857143 26.8037 19.471669227054573 20.10362885714286 20.9825 12.767324928116137 47.88878428571429 38.8511 41.464556278071946 0.520151;16.4324;64.9285;28.5803;31.9826;25.8316;26.8037 0.160202;10.5224;41.6103;22.529;24.4836;20.4374;20.9825 2.88499;39.929;136.455;38.8511;45.5891;34.8042;36.7081 0 Exp 2,6(0.47);Exp 4,1(0.08);Hill,1(0.08);Linear,2(0.16);Poly 2,3(0.24) 1.8334506148024758 24.036305785179138 1.541895866394043 2.4453113079071045 0.258329426100416 1.8264755010604858 22.736918850274154 55.53287361126431 16.7554616938372 38.53673246000895 21.919020793300668 140.1706853605455 CONFLICT 0.46153846153846156 0.5384615384615384 0.0 GO:0098657 5 import into cell 30 32 3 3 3 3 3 3 159 29 2356 0.85787 0.33306 0.45354 9.38 65192;29482;29184 slc27a2;slc1a2;cd36 SLC27A2_9860;SLC1A2_33059;CD36_8243 23.024996666666667 13.3235 7.62189 21.927332727466727 23.929408393773734 22.935612428934142 17.383993333333333 9.10952 5.49916 17.55155003960999 18.200116746651087 18.286964044355408 35.7373 24.6773 13.3925 29.47451738434406 36.59743567583357 31.082234984687876 0.5 10.472695 7.62189;13.3235;48.1296 5.49916;9.10952;37.5433 13.3925;24.6773;69.1421 2 1 2 65192;29184 SLC27A2_9860;CD36_8243 27.875745000000002 27.875745000000002 28.64327643133812 21.521230000000003 21.521230000000003 22.658628691291092 41.2673 41.2673 39.42092020843756 7.62189;48.1296 5.49916;37.5433 13.3925;69.1421 1 29482 SLC1A2_33059 13.3235 13.3235 9.10952 9.10952 24.6773 24.6773 13.3235 9.10952 24.6773 0 Exp 2,1(0.34);Hill,1(0.34);Poly 2,1(0.34) 2.1143907926914323 6.475338697433472 1.620316982269287 2.6703107357025146 0.525489389296105 2.18471097946167 -1.7881161808476094 47.83810951418094 -2.47745526119213 37.245441927858806 2.38374372967273 69.09085627032728 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0006139 4 nucleobase-containing compound metabolic process 359 401 44 43 32 40 29 29 133 372 2013 0.81474 0.2483 0.43541 7.23 79426;24856;360268;297784;298490;303612;24651;81819;25591;294103;100359982;24516;364070;63868;25675;499914;294515;314322;308441;24890;24330;83842;497840;25028;192272;170570;50559;170465;296925 zfp36;ttr;sult1e1;rrs1;ppcs;polg2;pklr;pax8;parp1;papss2;mpc2;jun;iars2;hspd1;hmgcr;gins1;foxo3;fos;exosc5;esr1;egr1;crot;cps1;ampd1;acot2;acot12;acot1;acaa2;aass ZFP36_10204;TTR_10102;SULT1E1_32446;RRS1_9755;PPCS_9540;POLG2_9521;PKLR_9489;PAX8_9432;PARP1_9425;PAPSS2_33237;MPC2_33219;JUN_8938;IARS2_8858;HSPD1_8849;HMGCR_8810;GINS1_8707;FOXO3_8662;FOS_8657;EXOSC5_32543;ESR1_33192;EGR1_8533;CROT_8384;CPS1_32421;AMPD1_32743;ACOT2_7969;ACOT12_32718;ACOT1_7968;ACAA2_7955;AASS_7936 30.263127275862114 27.4644 1.28141E-12 19.801101731704748 34.92944410322771 18.642560425252615 22.380661655172464 21.799 1.28141E-12 14.726588719227895 26.14159744888258 13.999702455437019 47.740624137931086 37.2719 1.28142E-12 34.100314706877164 53.77413884776737 32.45273462637796 19.5 42.0954 0.348134;46.6406;50.1846;60.39;20.3353;63.7758;23.0963;56.8931;26.9741;34.4443;46.8463;16.4324;24.7304;42.2579;1.63089;58.9165;13.1992;1.28141E-12;41.9329;23.3972;0.750017;7.4229;31.9826;60.9045;8.54905;30.3423;31.2018;26.5872;27.4644 0.118102;28.5876;36.5009;43.109;16.7643;40.9553;17.4625;45.1162;21.799;25.719;35.8494;10.5224;19.8021;23.9469;0.663137;44.7208;5.6804;1.28141E-12;31.7336;18.3088;0.186019;5.75707;24.4836;50.0633;7.19676;24.0157;26.858;21.3695;21.7498 1.15962;63.7146;80.9788;104.942;25.6711;132.567;32.9443;81.5688;35.2797;51.1014;69.127;39.929;32.7087;102.383;7.6286;91.837;32.7581;1.28142E-12;62.1373;31.9156;4.70178;10.316;45.5891;82.6625;10.4125;41.1025;37.2719;35.0407;37.0295 18 11 18 24856;360268;297784;298490;81819;25591;100359982;364070;63868;499914;308441;83842;25028;192272;170570;50559;170465;296925 TTR_10102;SULT1E1_32446;RRS1_9755;PPCS_9540;PAX8_9432;PARP1_9425;MPC2_33219;IARS2_8858;HSPD1_8849;GINS1_8707;EXOSC5_32543;CROT_8384;AMPD1_32743;ACOT2_7969;ACOT12_32718;ACOT1_7968;ACAA2_7955;AASS_7936 37.14299166666667 36.56735 16.977934832740377 28.052218333333332 25.43685 12.630009769113746 55.78797777777778 51.6199 30.212026258361874 46.6406;50.1846;60.39;20.3353;56.8931;26.9741;46.8463;24.7304;42.2579;58.9165;41.9329;7.4229;60.9045;8.54905;30.3423;31.2018;26.5872;27.4644 28.5876;36.5009;43.109;16.7643;45.1162;21.799;35.8494;19.8021;23.9469;44.7208;31.7336;5.75707;50.0633;7.19676;24.0157;26.858;21.3695;21.7498 63.7146;80.9788;104.942;25.6711;81.5688;35.2797;69.127;32.7087;102.383;91.837;62.1373;10.316;82.6625;10.4125;41.1025;37.2719;35.0407;37.0295 11 79426;303612;24651;294103;24516;25675;294515;314322;24890;24330;497840 ZFP36_10204;POLG2_9521;PKLR_9489;PAPSS2_33237;JUN_8938;HMGCR_8810;FOXO3_8662;FOS_8657;ESR1_33192;EGR1_8533;CPS1_32421 19.005167363636478 16.4324 19.57534964202729 13.099932545454662 10.5224 13.543215570319518 34.57222727272739 32.7581 37.37525692130361 0.348134;63.7758;23.0963;34.4443;16.4324;1.63089;13.1992;1.28141E-12;23.3972;0.750017;31.9826 0.118102;40.9553;17.4625;25.719;10.5224;0.663137;5.6804;1.28141E-12;18.3088;0.186019;24.4836 1.15962;132.567;32.9443;51.1014;39.929;7.6286;32.7581;1.28142E-12;31.9156;4.70178;45.5891 0 Exp 2,17(0.59);Exp 3,1(0.04);Exp 4,2(0.07);Hill,3(0.11);Linear,3(0.11);Poly 2,3(0.11) 2.6309959208897746 415.20417630672455 1.5504547357559204 344.14306640625 63.46603027385369 1.9248499870300293 23.05626160246176 37.469992949262476 17.02073026524615 27.740593045098777 35.32937597391367 60.15187230194847 UP 0.6206896551724138 0.3793103448275862 0.0 GO:0006953 7 acute-phase response 25 27 10 10 9 10 9 9 153 18 2367 1.0 2.3717E-5 2.3717E-5 33.33 24825;24648;288001;54404;24464;25661;361969;25698;25373 tf;serpina1;kng1;itih4;hp;fn1;fga;ass1;ahsg TF_10003;SERPINA1_9807;KNG1L1_34113;ITIH4_32725;HP_8823;FN1_8655;FGA_8632;ASS1_33159;AHSG_8003 37.191655555555556 28.5803 12.402 19.842158270971378 44.450717992016635 18.393510190467797 25.199577777777776 22.529 10.3013 10.886398029625985 28.98227457461876 9.910822027273849 60.904877777777784 38.8511 15.4235 43.30110883856721 75.5215935838714 42.077578693958834 0.5 14.099499999999999 1.5 20.08125 45.1539;15.797;24.3655;57.1163;64.9285;59.5777;28.5803;26.8037;12.402 28.132;13.013;19.538;39.6402;41.6103;31.0499;22.529;20.9825;10.3013 61.5341;19.9134;32.1467;101.869;136.455;105.243;38.8511;36.7081;15.4235 1 8 1 24825 TF_10003 45.1539 45.1539 28.132 28.132 61.5341 61.5341 45.1539 28.132 61.5341 8 24648;288001;54404;24464;25661;361969;25698;25373 SERPINA1_9807;KNG1L1_34113;ITIH4_32725;HP_8823;FN1_8655;FGA_8632;ASS1_33159;AHSG_8003 36.196374999999996 27.692 20.970618749421096 24.833025 21.75575 11.578522659741301 60.82622500000001 37.7796 46.29014520625774 15.797;24.3655;57.1163;64.9285;59.5777;28.5803;26.8037;12.402 13.013;19.538;39.6402;41.6103;31.0499;22.529;20.9825;10.3013 19.9134;32.1467;101.869;136.455;105.243;38.8511;36.7081;15.4235 0 Exp 2,4(0.45);Linear,3(0.34);Poly 2,1(0.12);Power,1(0.12) 1.9028561650818085 17.70563054084778 1.5197933912277222 3.431420087814331 0.6059017107151129 1.7792335748672485 24.228112151854255 50.15519895925686 18.087131065088805 32.312024490466754 32.6148200032472 89.19493555230837 DOWN 0.1111111111111111 0.8888888888888888 0.0 GO:0006357 8 regulation of transcription by RNA polymerase II 343 364 30 30 23 25 20 20 142 344 2041 0.27431 0.79969 0.56154 5.49 79426;24522;246273;83516;25513;81819;25591;25493;58954;24516;494344;290556;25112;294515;314322;24890;24330;25695;29184;79431 zfp36;zfp354a;trib3;ppargc1a;pik3r1;pax8;parp1;nfkbia;klf6;jun;ier2;gnl3;gadd45a;foxo3;fos;esr1;egr1;cebpd;cd36;bhlhe40 ZFP36_10204;ZFP354A_10203;TRIB3_10079;PPARGC1A_33189;PIK3R1_32562;PAX8_9432;PARP1_9425;NFKBIA_9307;KLF6_8969;JUN_8938;IER2_32643;GNL3_8735;GADD45A_8678;FOXO3_8662;FOS_8657;ESR1_33192;EGR1_8533;CEBPD_8283;CD36_8243;BHLHE40_8141 33.69918325000006 21.172400000000003 1.28141E-12 34.66402929910226 37.022500341621985 35.060338812703606 24.452405360000064 15.001450000000002 1.28141E-12 27.147218648952755 28.276704458018955 29.061852350009765 58.53999750000007 40.763400000000004 1.28142E-12 60.51661224938226 56.45936061986121 48.467829261903546 17.5 95.27735 0.348134;0.834827;108.064;42.4094;18.7324;56.8931;26.9741;0.520151;18.9476;16.4324;49.6814;87.6357;102.919;13.1992;1.28141E-12;23.3972;0.750017;0.306936;48.1296;57.8085 0.118102;0.27095;83.8836;26.2988;11.6701;45.1162;21.799;0.160202;11.6941;10.5224;33.4626;54.41;89.5012;5.6804;1.28141E-12;18.3088;0.186019;0.0732342;37.5433;38.3491 1.15962;2.99857;143.428;81.7305;41.5978;81.5688;35.2797;2.88499;45.5481;39.929;89.4404;238.963;115.437;32.7581;1.28142E-12;31.9156;4.70178;1.73689;69.1421;110.58 4 16 4 81819;25591;290556;29184 PAX8_9432;PARP1_9425;GNL3_8735;CD36_8243 54.908125 52.51135 25.174672755287872 39.717124999999996 41.329750000000004 13.7939033062618 106.23839999999998 75.35544999999999 90.61949972035084 56.8931;26.9741;87.6357;48.1296 45.1162;21.799;54.41;37.5433 81.5688;35.2797;238.963;69.1421 16 79426;24522;246273;83516;25513;25493;58954;24516;494344;25112;294515;314322;24890;24330;25695;79431 ZFP36_10204;ZFP354A_10203;TRIB3_10079;PPARGC1A_33189;PIK3R1_32562;NFKBIA_9307;KLF6_8969;JUN_8938;IER2_32643;GADD45A_8678;FOXO3_8662;FOS_8657;ESR1_33192;EGR1_8533;CEBPD_8283;BHLHE40_8141 28.39694781250008 17.5824 35.289200540627554 20.63622545000008 11.09625 28.59671833550186 46.61539687500008 36.34355 47.30861627705156 0.348134;0.834827;108.064;42.4094;18.7324;0.520151;18.9476;16.4324;49.6814;102.919;13.1992;1.28141E-12;23.3972;0.750017;0.306936;57.8085 0.118102;0.27095;83.8836;26.2988;11.6701;0.160202;11.6941;10.5224;33.4626;89.5012;5.6804;1.28141E-12;18.3088;0.186019;0.0732342;38.3491 1.15962;2.99857;143.428;81.7305;41.5978;2.88499;45.5481;39.929;89.4404;115.437;32.7581;1.28142E-12;31.9156;4.70178;1.73689;110.58 0 Exp 2,8(0.4);Exp 4,2(0.1);Hill,5(0.25);Poly 2,5(0.25) 2.011702050207008 42.32949149608612 1.5740432739257812 4.591650485992432 0.8301059838344855 1.8316379189491272 18.507002576180014 48.89136392382012 12.554612205374816 36.3501985146253 32.01742278350748 85.06257221649264 DOWN 0.2 0.8 0.0 GO:0071260 5 cellular response to mechanical stimulus 54 54 2 2 2 2 2 2 160 52 2333 0.32128 0.86854 0.57864 3.7 25112;24330 gadd45a;egr1 GADD45A_8678;EGR1_8533 51.8345085 51.8345085 0.750017 72.24438070623309 60.41632688270103 71.21766164456547 44.8436095 44.8436095 0.186019 63.15537014800388 52.34575584279044 62.257821830145105 60.06939 60.06939 4.70178 78.3016249781842 69.37074074955618 77.1888218765623 102.919;0.750017 89.5012;0.186019 115.437;4.70178 0 2 0 2 25112;24330 GADD45A_8678;EGR1_8533 51.8345085 51.8345085 72.24438070623309 44.8436095 44.8436095 63.15537014800388 60.06939 60.06939 78.3016249781842 102.919;0.750017 89.5012;0.186019 115.437;4.70178 0 Hill,1(0.5);Poly 2,1(0.5) 2.625361783427871 5.852249026298523 1.6339634656906128 4.21828556060791 1.8273916780862456 2.9261245131492615 -48.291094839999985 151.96011183999997 -42.685267879999984 132.37248688 -48.4511256 168.5899056 DOWN 0.0 1.0 0.0 GO:0007169 7 transmembrane receptor protein tyrosine kinase signaling pathway 107 112 8 8 8 8 8 8 154 104 2281 0.71968 0.42046 0.69121 7.14 25513;25685;24471;29455;294515;29496;116636;140942 pik3r1;igfbp1;hspb1;gdf15;foxo3;erbb3;eif4ebp1;ddit4 PIK3R1_32562;IGFBP1_32306;HSPB1_8847;GDF15_33113;FOXO3_8662;ERBB3_8571;EIF4EBP1_8550;DDIT4_8450 63.456025 72.44924999999999 13.1992 34.08873456142493 74.40575344195635 30.14627558878783 41.622675 42.01105 5.6804 25.818997388564753 50.02875426665139 24.97754413116117 107.76152499999999 106.729 32.7581 65.11554242282935 108.96068207147358 45.55241071188683 4.5 85.7211 18.7324;49.0259;89.1011;105.149;13.1992;60.9984;83.9001;87.5421 11.6701;32.6883;60.3265;85.3487;5.6804;41.6036;42.4185;53.2453 41.5978;89.1623;106.138;125.652;32.7581;113.972;107.32;245.492 2 6 2 29496;116636 ERBB3_8571;EIF4EBP1_8550 72.44924999999999 72.44924999999999 16.193947370699963 42.01105 42.01105 0.5762213159891929 110.64599999999999 110.64599999999999 4.703674308453421 60.9984;83.9001 41.6036;42.4185 113.972;107.32 6 25513;25685;24471;29455;294515;140942 PIK3R1_32562;IGFBP1_32306;HSPB1_8847;GDF15_33113;FOXO3_8662;DDIT4_8450 60.45828333333333 68.284 39.13150626834683 41.49321666666666 42.9668 30.54704609289852 106.80003333333333 97.65015 76.98821379111651 18.7324;49.0259;89.1011;105.149;13.1992;87.5421 11.6701;32.6883;60.3265;85.3487;5.6804;53.2453 41.5978;89.1623;106.138;125.652;32.7581;245.492 0 Exp 2,1(0.13);Exp 3,1(0.13);Exp 4,1(0.13);Linear,2(0.25);Poly 2,3(0.38) 1.8795327363470926 15.817434668540955 1.5606178045272827 3.9562058448791504 0.8098204363135839 1.673216462135315 39.83373713695724 87.07831286304275 23.73102262584593 59.51432737415407 62.63875622433352 152.88429377566646 DOWN 0.25 0.75 0.0 GO:0007346 6 regulation of mitotic cell cycle 146 155 8 8 6 6 4 4 158 151 2234 0.0249 0.9918 0.041868 2.58 257644;25112;116636;114851 zwint;gadd45a;eif4ebp1;cdkn1a ZWINT_10214;GADD45A_8678;EIF4EBP1_8550;CDKN1A_8271 61.2672675 67.9502 6.24967 42.268682845745545 61.190339170757106 47.84286848333965 43.3153625 40.66 2.44025 35.70337496641307 44.26538241484456 41.06035253174479 80.669725 94.09065 19.0606 43.64524240108155 77.97669498363825 49.42738545302865 52.0003;102.919;83.9001;6.24967 38.9015;89.5012;42.4185;2.44025 80.8613;115.437;107.32;19.0606 2 2 2 257644;116636 ZWINT_10214;EIF4EBP1_8550 67.9502 67.9502 22.556564898494656 40.66 40.66 2.4868945494331998 94.09065 94.09065 18.709126191380534 52.0003;83.9001 38.9015;42.4185 80.8613;107.32 2 25112;114851 GADD45A_8678;CDKN1A_8271 54.584334999999996 54.584334999999996 68.35553877576015 45.970725 45.970725 61.56138812154295 67.2488 67.2488 68.14840598634717 102.919;6.24967 89.5012;2.44025 115.437;19.0606 0 Exp 2,1(0.25);Exp 3,1(0.25);Exp 4,1(0.25);Poly 2,1(0.25) 1.5860015050392413 6.34971284866333 1.5207922458648682 1.672852873802185 0.0778256019054785 1.5780338644981384 19.843958311169345 102.69057668883065 8.326055032915185 78.3046699670848 37.89738744694009 123.44206255305991 CONFLICT 0.5 0.5 0.0 GO:0051241 5 negative regulation of multicellular organismal process 326 344 32 32 25 26 21 21 141 323 2062 0.47411 0.61973 0.90584 6.1 79426;29573;24794;25106;85253;25513;81819;25591;25493;288001;25675;29455;25112;294515;25661;361969;25423;113936;29184;25373;312382 zfp36;slc37a4;serpina3c;rgn;plg;pik3r1;pax8;parp1;nfkbia;kng1;hmgcr;gdf15;gadd45a;foxo3;fn1;fga;ctsc;cpb2;cd36;ahsg;abcg2 ZFP36_10204;SLC37A4_9871;SERPINA3C_32925;RGN_9699;PLG_9501;PIK3R1_32562;PAX8_9432;PARP1_9425;NFKBIA_9307;KNG1L1_34113;HMGCR_8810;GDF15_33113;GADD45A_8678;FOXO3_8662;FN1_8655;FGA_8632;CTSC_32456;CPB2_8369;CD36_8243;AHSG_8003;ABCG2_32656 38.30556261904761 28.5803 0.348134 31.690882044352378 48.92912519160606 31.017332461695535 28.26212480952381 22.529 0.118102 25.60406888813304 36.028993925607075 25.944878141949953 56.90923380952381 40.8256 1.15962 43.84387122031225 72.36093298630517 43.12864669928633 16.5 65.1817 0.348134;39.7166;29.766;77.4407;70.7857;18.7324;56.8931;26.9741;0.520151;24.3655;1.63089;105.149;102.919;13.1992;59.5777;28.5803;56.2386;25.8316;48.1296;12.402;5.21654 0.118102;22.6911;23.347;58.7732;46.2356;11.6701;45.1162;21.799;0.160202;19.538;0.663137;85.3487;89.5012;5.6804;31.0499;22.529;38.2681;20.4374;37.5433;10.3013;2.73368 1.15962;60.0334;40.8256;89.8047;150.579;41.5978;81.5688;35.2797;2.88499;32.1467;7.6286;125.652;115.437;32.7581;105.243;38.8511;102.888;34.8042;69.1421;15.4235;11.386 5 16 5 25106;81819;25591;29184;312382 RGN_9699;PAX8_9432;PARP1_9425;CD36_8243;ABCG2_32656 42.930808 48.1296 27.79338150971054 33.193076000000005 37.5433 21.639245892610955 57.43625999999999 69.1421 33.0857283511033 77.4407;56.8931;26.9741;48.1296;5.21654 58.7732;45.1162;21.799;37.5433;2.73368 89.8047;81.5688;35.2797;69.1421;11.386 16 79426;29573;24794;85253;25513;25493;288001;25675;29455;25112;294515;25661;361969;25423;113936;25373 ZFP36_10204;SLC37A4_9871;SERPINA3C_32925;PLG_9501;PIK3R1_32562;NFKBIA_9307;KNG1L1_34113;HMGCR_8810;GDF15_33113;GADD45A_8678;FOXO3_8662;FN1_8655;FGA_8632;CTSC_32456;CPB2_8369;AHSG_8003 36.860173437499995 27.20595 33.52209321194563 26.7212025625 21.4832 27.17692227019764 56.744538125000005 39.838350000000005 47.655161603511004 0.348134;39.7166;29.766;70.7857;18.7324;0.520151;24.3655;1.63089;105.149;102.919;13.1992;59.5777;28.5803;56.2386;25.8316;12.402 0.118102;22.6911;23.347;46.2356;11.6701;0.160202;19.538;0.663137;85.3487;89.5012;5.6804;31.0499;22.529;38.2681;20.4374;10.3013 1.15962;60.0334;40.8256;150.579;41.5978;2.88499;32.1467;7.6286;125.652;115.437;32.7581;105.243;38.8511;102.888;34.8042;15.4235 0 Exp 2,6(0.29);Exp 4,4(0.2);Hill,1(0.05);Linear,4(0.2);Poly 2,5(0.24);Power,1(0.05) 1.8309655342017235 39.31850588321686 1.5074360370635986 3.431420087814331 0.4582599751055026 1.7521979808807373 24.75114847695253 51.8599767611427 17.311083656842012 39.21316596220559 38.15690033767264 75.66156728137497 DOWN 0.23809523809523808 0.7619047619047619 0.0 GO:0003013 4 circulatory system process 81 84 13 13 11 11 9 9 153 75 2310 0.96217 0.082395 0.10756 10.71 298490;288001;25675;361969;304929;497840;29184;312382;25303 ppcs;kng1;hmgcr;fga;f5;cps1;cd36;abcg2;abcc2 PPCS_9540;KNG1L1_34113;HMGCR_8810;FGA_8632;F5_33079;CPS1_32421;CD36_8243;ABCG2_32656;ABCC2_32541 24.120136666666667 24.3655 1.63089 16.60998727240482 27.77538217906935 16.59201432803211 17.558345222222222 19.538 0.663137 13.18788654022444 20.83936651801557 13.177585910806187 38.85636666666667 37.5078 7.6286 24.38208801958929 42.07708862484157 24.198117962267858 3.5 22.3504 7.5 47.1806 20.3353;24.3655;1.63089;28.5803;10.6089;31.9826;48.1296;5.21654;46.2316 16.7643;19.538;0.663137;22.529;2.59129;24.4836;37.5433;2.73368;31.1788 25.6711;32.1467;7.6286;38.8511;37.5078;45.5891;69.1421;11.386;81.7848 3 6 3 298490;29184;312382 PPCS_9540;CD36_8243;ABCG2_32656 24.560480000000002 20.3353 21.766299390691106 19.01376 16.7643 17.513493764945935 35.39973333333333 25.6711 30.081996305154586 20.3353;48.1296;5.21654 16.7643;37.5433;2.73368 25.6711;69.1421;11.386 6 288001;25675;361969;304929;497840;25303 KNG1L1_34113;HMGCR_8810;FGA_8632;F5_33079;CPS1_32421;ABCC2_32541 23.899964999999998 26.472900000000003 15.86642542638228 16.83063783333333 21.0335 12.396659539439495 40.58468333333334 38.17945 24.051067806433593 24.3655;1.63089;28.5803;10.6089;31.9826;46.2316 19.538;0.663137;22.529;2.59129;24.4836;31.1788 32.1467;7.6286;38.8511;37.5078;45.5891;81.7848 0 Exp 2,4(0.45);Exp 4,2(0.23);Hill,1(0.12);Linear,2(0.23) 1.9379660738554219 17.763067603111267 1.5074360370635986 2.6703107357025146 0.40704232880818203 1.8589661121368408 13.268278315362187 34.971995017971146 8.942259349275588 26.174431095168856 22.92673582720166 54.78599750613167 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:2000296 8 negative regulation of hydrogen peroxide catabolic process 1 1 1 1 1 1 1 1 161 0 2385 1.0 0.063604 0.063604 100.0 24464 hp HP_8823 64.9285 64.9285 64.9285 64.9285 41.6103 41.6103 41.6103 41.6103 136.455 136.455 136.455 136.455 0.0 64.9285 0.0 64.9285 64.9285 41.6103 136.455 0 1 0 1 24464 HP_8823 64.9285 64.9285 41.6103 41.6103 136.455 136.455 64.9285 41.6103 136.455 0 Exp 2,1(1) 1.6336230039596558 1.6336230039596558 1.6336230039596558 1.6336230039596558 0.0 1.6336230039596558 64.9285 64.9285 41.6103 41.6103 136.455 136.455 DOWN 0.0 1.0 0.0 GO:0006996 5 organelle organization 397 425 20 19 14 18 13 13 149 412 1973 7.7524E-4 0.9997 0.0014713 3.06 257644;24522;296554;171139;308821;83516;303612;25591;24516;63868;85255;50681;170465 zwint;zfp354a;tubb4b;timm9;rab30;ppargc1a;polg2;parp1;jun;hspd1;hacl1;acox1;acaa2 ZWINT_10214;ZFP354A_10203;TUBB4B_34097;TIMM9_10020;RAB30_9639;PPARGC1A_33189;POLG2_9521;PARP1_9425;JUN_8938;HSPD1_8849;HACL1_8775;ACOX1_7973;ACAA2_7955 171139(0.04986) 33.829978999999994 26.9741 0.834827 18.60093455493612 30.80884095147749 19.61002546789969 23.78422692307693 21.799 0.27095 13.125005739976755 21.70692947659984 13.807159673618836 59.55766692307692 39.929 2.99857 36.97940651749371 54.11721776403221 38.72358335907577 52.0003;0.834827;62.7603;38.5191;26.4203;42.4094;63.7758;26.9741;16.4324;42.2579;17.6275;23.1906;26.5872 38.9015;0.27095;47.0916;29.55;21.0125;26.2988;40.9553;21.799;10.5224;23.9469;11.195;16.2815;21.3695 80.8613;2.99857;101.528;55.4685;35.3561;81.7305;132.567;35.2797;39.929;102.383;37.6534;33.4539;35.0407 9 4 9 257644;296554;171139;308821;25591;63868;85255;50681;170465 ZWINT_10214;TUBB4B_34097;TIMM9_10020;RAB30_9639;PARP1_9425;HSPD1_8849;HACL1_8775;ACOX1_7973;ACAA2_7955 35.148588888888895 26.9741 14.893682120402964 25.683055555555555 21.799 11.207253695387545 57.44717777777779 37.6534 29.503002694250345 52.0003;62.7603;38.5191;26.4203;26.9741;42.2579;17.6275;23.1906;26.5872 38.9015;47.0916;29.55;21.0125;21.799;23.9469;11.195;16.2815;21.3695 80.8613;101.528;55.4685;35.3561;35.2797;102.383;37.6534;33.4539;35.0407 4 24522;83516;303612;24516 ZFP354A_10203;PPARGC1A_33189;POLG2_9521;JUN_8938 30.86310675 29.4209 27.847831434615905 19.5118625 18.4106 17.859700280397345 64.3062675 60.829750000000004 55.72556691253031 0.834827;42.4094;63.7758;16.4324 0.27095;26.2988;40.9553;10.5224 2.99857;81.7305;132.567;39.929 0 Exp 2,7(0.54);Exp 3,1(0.08);Hill,1(0.08);Linear,1(0.08);Poly 2,2(0.16);Power,1(0.08) 2.2362993176299817 32.193941950798035 1.5207922458648682 5.973292827606201 1.3565083367055093 1.8086696863174438 23.71839579335621 43.941562206643795 16.649392528843 30.919061317310845 39.455432552561575 79.65990129359228 UP 0.6923076923076923 0.3076923076923077 0.0 GO:0019725 4 cellular homeostasis 217 230 29 29 24 24 20 20 142 210 2175 0.94679 0.087674 0.15443 8.7 24825;29573;25106;83516;85253;25513;360722;24314;24567;288001;81678;81869;294515;25661;24890;25428;113936;29184;155423;25303 tf;slc37a4;rgn;ppargc1a;plg;pik3r1;pdia5;nqo1;mt1;kng1;itpr2;gstm7;foxo3;fn1;esr1;cyp7a1;cpb2;cd36;anxa7;abcc2 TF_10003;SLC37A4_9871;RGN_9699;PPARGC1A_33189;PLG_9501;PIK3R1_32562;PDIA5_9451;NQO1_33055;MT1A_9255;KNG1L1_34113;ITPR2_8931;GSTM7_8761;FOXO3_8662;FN1_8655;ESR1_33192;CYP7A1_8430;CPB2_8369;CD36_8243;ANXA7_8051;ABCC2_32541 46.336634 42.3623 5.72128 29.779885740616482 50.68671059021998 23.89331830181796 29.476570149999997 27.215400000000002 0.985273 17.64512555516919 31.96689038203473 13.54688916258768 72.39469 63.06660000000001 22.3625 45.60356933269588 78.76779053263753 36.46852726469574 10.5 43.78165 45.1539;39.7166;77.4407;42.4094;70.7857;18.7324;107.066;87.2765;12.9315;24.3655;31.8111;42.3152;13.1992;59.5777;23.3972;5.72128;25.8316;48.1296;104.64;46.2316 28.132;22.6911;58.7732;26.2988;46.2356;11.6701;61.3361;60.6992;8.91033;19.538;24.7342;31.4035;5.6804;31.0499;18.3088;0.985273;20.4374;37.5433;43.9254;31.1788 61.5341;60.0334;89.8047;81.7305;150.579;41.5978;114.259;197.117;23.4636;32.1467;44.3296;64.5991;32.7581;105.243;31.9156;22.3625;34.8042;69.1421;108.689;81.7848 6 14 6 24825;25106;24314;81869;29184;155423 TF_10003;RGN_9699;NQO1_33055;GSTM7_8761;CD36_8243;ANXA7_8051 67.49265 62.78515 25.99285085178232 43.41276666666667 40.734350000000006 13.763730869595875 98.481 79.4734 51.540992544032356 45.1539;77.4407;87.2765;42.3152;48.1296;104.64 28.132;58.7732;60.6992;31.4035;37.5433;43.9254 61.5341;89.8047;197.117;64.5991;69.1421;108.689 14 29573;83516;85253;25513;360722;24567;288001;81678;294515;25661;24890;25428;113936;25303 SLC37A4_9871;PPARGC1A_33189;PLG_9501;PIK3R1_32562;PDIA5_9451;MT1A_9255;KNG1L1_34113;ITPR2_8931;FOXO3_8662;FN1_8655;ESR1_33192;CYP7A1_8430;CPB2_8369;ABCC2_32541 37.26977 28.821350000000002 27.224811118462963 23.5039145 21.56425 15.941564363799449 61.21484285714286 42.9637 39.61238777998453 39.7166;42.4094;70.7857;18.7324;107.066;12.9315;24.3655;31.8111;13.1992;59.5777;23.3972;5.72128;25.8316;46.2316 22.6911;26.2988;46.2356;11.6701;61.3361;8.91033;19.538;24.7342;5.6804;31.0499;18.3088;0.985273;20.4374;31.1788 60.0334;81.7305;150.579;41.5978;114.259;23.4636;32.1467;44.3296;32.7581;105.243;31.9156;22.3625;34.8042;81.7848 0 Exp 2,6(0.3);Exp 3,2(0.1);Exp 4,1(0.05);Hill,1(0.05);Linear,4(0.2);Poly 2,5(0.25);Power,1(0.05) 1.9320252288512159 40.1239013671875 1.5254690647125244 4.560328960418701 0.6824913540472731 1.7684283256530762 33.28502361987376 59.388244380126245 21.743252908276105 37.209887391723896 52.40804451527156 92.38133548472837 DOWN 0.3 0.7 0.0 GO:0033574 5 response to testosterone 28 31 8 8 5 4 2 2 160 29 2356 0.68484 0.59663 1.0 6.45 286954;25513 ugt2b1;pik3r1 UGT2B10_33303,UGT2B1_33224;PIK3R1_32562 33.102925 33.102925 18.7324 20.32299135342162 39.32578887460228 18.31873106816052 23.249624999999998 23.249624999999998 11.6701 16.375921300838314 28.263903031425706 14.760922399984784 59.036275 59.036275 41.5978 24.66172785210416 66.58765228827964 22.22957990496805 0.5 33.102925 47.47345;18.7324 34.82915;11.6701 76.47475;41.5978 2 1 1 286954 UGT2B10_33303,UGT2B1_33224 47.47345 47.47345 34.82915 34.82915 76.47475 76.47475 47.47345 34.82915 76.47475 1 25513 PIK3R1_32562 18.7324 18.7324 11.6701 11.6701 41.5978 41.5978 18.7324 11.6701 41.5978 0 Exp 2,2(0.67);Poly 2,1(0.34) 1.6952868803424712 5.088585138320923 1.6419988870620728 1.7730062007904053 0.06836890801655725 1.6735800504684448 4.936696000000001 61.269154 0.5537559999999999 45.945494 24.856864 93.215686 CONFLICT 0.5 0.5 0.0 GO:0007598 5 blood coagulation, extrinsic pathway 1 1 1 1 1 1 1 1 161 0 2385 1.0 0.063604 0.063604 100.0 304929 f5 F5_33079 10.6089 10.6089 10.6089 10.6089 2.59129 2.59129 2.59129 2.59129 37.5078 37.5078 37.5078 37.5078 0.0 10.6089 0.0 10.6089 10.6089 2.59129 37.5078 0 1 0 1 304929 F5_33079 10.6089 10.6089 2.59129 2.59129 37.5078 37.5078 10.6089 2.59129 37.5078 0 Hill,1(1) 1.7042291164398193 1.7042291164398193 1.7042291164398193 1.7042291164398193 0.0 1.7042291164398193 10.6089 10.6089 2.59129 2.59129 37.5078 37.5078 DOWN 0.0 1.0 0.0 GO:0034312 7 diol biosynthetic process 6 8 1 1 1 1 1 1 161 7 2378 0.91259 0.40932 0.40932 12.5 25315 ephx1 EPHX1_8567 12.4747 12.4747 12.4747 12.4747 7.00435 7.00435 7.00435 7.004349999999999 23.684 23.684 23.684 23.684 0.0 12.4747 0.0 12.4747 12.4747 7.00435 23.684 1 0 1 25315 EPHX1_8567 12.4747 12.4747 7.00435 7.00435 23.684 23.684 12.4747 7.00435 23.684 0 0 Hill,1(1) 2.4453113079071045 2.4453113079071045 2.4453113079071045 2.4453113079071045 0.0 2.4453113079071045 12.4747 12.4747 7.00435 7.00435 23.684 23.684 UP 1.0 0.0 0.0 GO:0009894 5 regulation of catabolic process 212 227 20 20 16 16 12 12 150 215 2170 0.29882 0.79597 0.56983 5.29 79426;246273;25106;192280;83516;24464;25675;294515;24360;140942;25423;246142 zfp36;trib3;rgn;ppp1r3b;ppargc1a;hp;hmgcr;foxo3;fabp1;ddit4;ctsc;bmf ZFP36_10204;TRIB3_10079;RGN_9699;PPP1R3B_9545;PPARGC1A_33189;HP_8823;HMGCR_8810;FOXO3_8662;FABP1_33091;DDIT4_8450;CTSC_32456;BMF_8152 51.388926999999995 49.324 0.348134 36.251815972053684 59.06257301583726 30.009299212718616 36.26729491666667 32.66345 0.118102 27.375939377030708 42.523639817855276 23.517822358344944 87.64521833333333 85.7676 1.15962 68.0141576845535 92.63799885579938 48.67408172335918 10.5 101.47035 0.348134;108.064;77.4407;36.1411;42.4094;64.9285;1.63089;13.1992;33.8478;87.5421;56.2386;94.8767 0.118102;83.8836;58.7732;27.0588;26.2988;41.6103;0.663137;5.6804;26.4736;53.2453;38.2681;73.1342 1.15962;143.428;89.8047;53.6244;81.7305;136.455;7.6286;32.7581;46.9257;245.492;102.888;109.848 3 9 3 25106;24360;246142 RGN_9699;FABP1_33091;BMF_8152 68.72173333333333 77.4407 31.434804653494094 52.793666666666674 58.7732 23.8980964148472 82.19279999999999 89.8047 32.144357600207236 77.4407;33.8478;94.8767 58.7732;26.4736;73.1342 89.8047;46.9257;109.848 9 79426;246273;192280;83516;24464;25675;294515;140942;25423 ZFP36_10204;TRIB3_10079;PPP1R3B_9545;PPARGC1A_33189;HP_8823;HMGCR_8810;FOXO3_8662;DDIT4_8450;CTSC_32456 45.611324888888895 42.4094 37.54686602305524 30.75850433333333 27.0588 27.40698074200259 89.46269111111111 81.7305 78.02223015521417 0.348134;108.064;36.1411;42.4094;64.9285;1.63089;13.1992;87.5421;56.2386 0.118102;83.8836;27.0588;26.2988;41.6103;0.663137;5.6804;53.2453;38.2681 1.15962;143.428;53.6244;81.7305;136.455;7.6286;32.7581;245.492;102.888 0 Exp 2,5(0.42);Exp 4,2(0.17);Hill,1(0.09);Linear,1(0.09);Poly 2,3(0.25) 1.7881947993411986 21.51383352279663 1.5736411809921265 1.9883413314819336 0.1337721352294363 1.8164827823638916 30.877531204123603 71.90032279587642 20.777899067392067 51.75669076594127 49.162585930408376 126.1278507362583 DOWN 0.25 0.75 0.0 GO:0007596 5 blood coagulation 27 28 6 6 6 6 6 6 156 22 2363 0.9986 0.0070377 0.0070377 21.43 79224;85253;294103;361969;304929;113936 serpind1;plg;papss2;fga;f5;cpb2 SERPIND1_9812;PLG_9501;PAPSS2_33237;FGA_8632;F5_33079;CPB2_8369 33.0853 28.420650000000002 10.6089 20.122329175818603 40.579141473854705 22.51975646121486 23.303214999999998 22.418 2.59129 13.932113156063226 28.521967752198055 14.028944634862265 58.528316666666676 38.588750000000005 34.8042 45.44995823674281 73.73348771787754 55.63934504000706 0.5 18.22025 1.5 27.046300000000002 28.261;70.7857;34.4443;28.5803;10.6089;25.8316 22.307;46.2356;25.719;22.529;2.59129;20.4374 38.3264;150.579;51.1014;38.8511;37.5078;34.8042 0 6 0 6 79224;85253;294103;361969;304929;113936 SERPIND1_9812;PLG_9501;PAPSS2_33237;FGA_8632;F5_33079;CPB2_8369 33.0853 28.420650000000002 20.122329175818603 23.303214999999998 22.418 13.932113156063226 58.528316666666676 38.588750000000005 45.44995823674281 28.261;70.7857;34.4443;28.5803;10.6089;25.8316 22.307;46.2356;25.719;22.529;2.59129;20.4374 38.3264;150.579;51.1014;38.8511;37.5078;34.8042 0 Exp 2,2(0.34);Hill,1(0.17);Linear,3(0.5) 1.6158428488740395 9.713576436042786 1.5254690647125244 1.8057876825332642 0.11142628879523207 1.5680973529815674 16.984083287089057 49.18651671291095 12.15520269811666 34.451227301883335 22.16077587313039 94.89585746020295 DOWN 0.0 1.0 0.0 GO:0070988 3 demethylation 11 12 3 3 3 2 2 2 160 10 2375 0.96369 0.17482 0.17482 16.67 29441;266682 por;cyp3a2 POR_9531;CYP3A2_32374 12.64595 12.64595 12.4414 0.28927738418350274 12.670604796968828 0.2871683948016968 7.910785000000001 7.910785000000001 7.33176 0.8188650079530698 7.840994025593366 0.812895036909902 51.6319 51.6319 24.0283 39.037385490321974 48.30478607377752 38.75278172936588 0.0 12.4414 0.5 12.64595 12.4414;12.8505 8.48981;7.33176 79.2355;24.0283 1 1 1 266682 CYP3A2_32374 12.8505 12.8505 7.33176 7.33176 24.0283 24.0283 12.8505 7.33176 24.0283 1 29441 POR_9531 12.4414 12.4414 8.48981 8.48981 79.2355 79.2355 12.4414 8.48981 79.2355 0 Hill,1(0.5);Poly 2,1(0.5) 2.5011731191724538 5.138383150100708 1.9819281101226807 3.1564550399780273 0.8305159567869321 2.569191575050354 12.245031999999998 13.046868 6.775896 9.045674000000002 -2.4711559999999935 105.734956 CONFLICT 0.5 0.5 0.0 GO:1901031 7 regulation of response to reactive oxygen species 23 27 4 4 4 4 4 4 158 23 2362 0.97479 0.088224 0.088224 14.81 293615;25106;294515;29184 sirt3;rgn;foxo3;cd36 SIRT3_9828;RGN_9699;FOXO3_8662;CD36_8243 35.287420000000004 30.6644 2.38018 34.21791202034786 41.3175535173795 32.22980365421254 25.639747500000002 21.61185 0.56209 27.488086480043652 31.12101493396272 25.53464732805406 50.133517499999996 50.9501 8.82917 36.25411785948219 56.51550538931008 35.47489472332906 0.5 7.78969 1.5 30.6644 2.38018;77.4407;13.1992;48.1296 0.56209;58.7732;5.6804;37.5433 8.82917;89.8047;32.7581;69.1421 3 1 3 293615;25106;29184 SIRT3_9828;RGN_9699;CD36_8243 42.65016000000001 48.1296 37.82907099973247 32.29286333333334 37.5433 29.458592053101135 55.92532333333333 69.1421 42.07459451720996 2.38018;77.4407;48.1296 0.56209;58.7732;37.5433 8.82917;89.8047;69.1421 1 294515 FOXO3_8662 13.1992 13.1992 5.6804 5.6804 32.7581 32.7581 13.1992 5.6804 32.7581 0 Exp 2,1(0.25);Exp 4,1(0.25);Hill,1(0.25);Poly 2,1(0.25) 1.9304940071022798 7.899510860443115 1.5209722518920898 2.6703107357025146 0.5016170595591667 1.8541139364242554 1.7538662200590949 68.82097377994091 -1.2985772504427757 52.57807225044278 14.60448199770746 85.66255300229253 UP 0.75 0.25 0.0 GO:0006259 5 DNA metabolic process 110 119 5 5 5 5 5 5 157 114 2271 0.2185 0.88684 0.44018 4.2 303612;25591;63868;499914;308441 polg2;parp1;hspd1;gins1;exosc5 POLG2_9521;PARP1_9425;HSPD1_8849;GINS1_8707;EXOSC5_32543 46.77144 42.2579 26.9741 14.767946075470354 46.10655929938871 15.916218913123828 32.631119999999996 31.7336 21.799 10.111977774253662 32.479741443683885 11.448211601388934 84.8408 91.837 35.2797 37.437338671371926 82.74136083678027 37.46546160626452 63.7758;26.9741;42.2579;58.9165;41.9329 40.9553;21.799;23.9469;44.7208;31.7336 132.567;35.2797;102.383;91.837;62.1373 4 1 4 25591;63868;499914;308441 PARP1_9425;HSPD1_8849;GINS1_8707;EXOSC5_32543 42.52034999999999 42.0954 13.050333346828106 30.550075 27.840249999999997 10.36650716148726 72.90925 76.98715 30.325894321135294 26.9741;42.2579;58.9165;41.9329 21.799;23.9469;44.7208;31.7336 35.2797;102.383;91.837;62.1373 1 303612 POLG2_9521 63.7758 63.7758 40.9553 40.9553 132.567 132.567 63.7758 40.9553 132.567 0 Exp 2,4(0.8);Exp 3,1(0.2) 1.7380106623113847 8.780521988868713 1.5504547357559204 2.2518506050109863 0.29575170517992405 1.5979743003845215 33.82676452538125 59.716115474618746 23.767580681442297 41.494659318557694 52.02552580697924 117.65607419302077 UP 0.8 0.2 0.0 GO:0062014 6 negative regulation of small molecule metabolic process 34 38 8 8 7 7 6 6 156 32 2353 0.99128 0.030485 0.030485 15.79 246273;83516;25591;140942;25428;25287 trib3;ppargc1a;parp1;ddit4;cyp7a1;acadl TRIB3_10079;PPARGC1A_33189;PARP1_9425;DDIT4_8450;CYP7A1_8430;ACADL_32776 50.69978 37.9486 5.72128 38.984525876219145 49.754530923951044 35.0694760682772 35.46931216666667 26.451349999999998 0.985273 28.97809251184708 35.994150043662586 26.497910225723878 95.60258333333333 63.526650000000004 22.3625 85.41376830041902 83.60245999125875 68.87701693128263 0.5 16.34769 2.5 37.9486 108.064;42.4094;26.9741;87.5421;5.72128;33.4878 83.8836;26.2988;21.799;53.2453;0.985273;26.6039 143.428;81.7305;35.2797;245.492;22.3625;45.3228 2 4 2 25591;25287 PARP1_9425;ACADL_32776 30.23095 30.23095 4.605881440614799 24.20145 24.20145 3.3975773729232217 40.301249999999996 40.301249999999996 7.101544114134686 26.9741;33.4878 21.799;26.6039 35.2797;45.3228 4 246273;83516;140942;25428 TRIB3_10079;PPARGC1A_33189;DDIT4_8450;CYP7A1_8430 60.934194999999995 64.97575 45.901463812592816 41.10324325 39.77205 35.61933717659481 123.25325000000001 112.57925 95.3107457080085 108.064;42.4094;87.5421;5.72128 83.8836;26.2988;53.2453;0.985273 143.428;81.7305;245.492;22.3625 0 Exp 2,3(0.5);Hill,1(0.17);Linear,1(0.17);Poly 2,1(0.17) 2.099417551677287 13.558200716972351 1.6672165393829346 4.560328960418701 1.1300027962143502 1.842902958393097 19.505662554719038 81.89389744528096 12.282008978090783 58.656615355242536 27.257334547517104 163.94783211914955 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0031401 8 positive regulation of protein modification process 319 340 22 22 17 20 15 15 147 325 2060 0.067167 0.96079 0.12145 4.41 246273;24825;25513;24516;25675;290556;29455;299626;25112;361969;24890;29496;24330;114851;29184 trib3;tf;pik3r1;jun;hmgcr;gnl3;gdf15;gadd45b;gadd45a;fga;esr1;erbb3;egr1;cdkn1a;cd36 TRIB3_10079;TF_10003;PIK3R1_32562;JUN_8938;HMGCR_8810;GNL3_8735;GDF15_33113;GADD45B_8679;GADD45A_8678;FGA_8632;ESR1_33192;ERBB3_8571;EGR1_8533;CDKN1A_8271;CD36_8243 50.67929846666666 45.1539 0.750017 41.31598942260997 50.55193567746856 39.68417831941241 35.96368706666667 28.132 0.186019 31.279305258959862 38.18056855447579 32.70175815579157 77.41644533333333 61.5341 4.70178 63.649856551506836 71.03712672439435 49.71527089557083 108.064;45.1539;18.7324;16.4324;1.63089;87.6357;105.149;106.367;102.919;28.5803;23.3972;60.9984;0.750017;6.24967;48.1296 83.8836;28.132;11.6701;10.5224;0.663137;54.41;85.3487;52.7132;89.5012;22.529;18.3088;41.6036;0.186019;2.44025;37.5433 143.428;61.5341;41.5978;39.929;7.6286;238.963;125.652;109.434;115.437;38.8511;31.9156;113.972;4.70178;19.0606;69.1421 5 10 5 24825;290556;299626;29496;29184 TF_10003;GNL3_8735;GADD45B_8679;ERBB3_8571;CD36_8243 69.65692 60.9984 26.50311287371728 42.88042 41.6036 10.922977950266128 118.60904000000001 109.434 71.23076251805112 45.1539;87.6357;106.367;60.9984;48.1296 28.132;54.41;52.7132;41.6036;37.5433 61.5341;238.963;109.434;113.972;69.1421 10 246273;25513;24516;25675;29455;25112;361969;24890;24330;114851 TRIB3_10079;PIK3R1_32562;JUN_8938;HMGCR_8810;GDF15_33113;GADD45A_8678;FGA_8632;ESR1_33192;EGR1_8533;CDKN1A_8271 41.19048769999999 21.064799999999998 45.20000969347583 32.5053206 14.989450000000001 37.80281350056102 56.820147999999996 39.39005 51.31249502961607 108.064;18.7324;16.4324;1.63089;105.149;102.919;28.5803;23.3972;0.750017;6.24967 83.8836;11.6701;10.5224;0.663137;85.3487;89.5012;22.529;18.3088;0.186019;2.44025 143.428;41.5978;39.929;7.6286;125.652;115.437;38.8511;31.9156;4.70178;19.0606 0 Exp 2,3(0.2);Exp 4,2(0.14);Hill,1(0.07);Linear,2(0.14);Poly 2,6(0.4);Power,1(0.07) 1.8899207660740076 29.586171746253967 1.522104263305664 4.21828556060791 0.7074801541625886 1.6735800504684448 29.770522975128923 71.58807395820442 20.13417456241176 51.79319957092159 45.205173636769665 109.62771702989698 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0006710 6 androgen catabolic process 4 4 3 3 2 1 1 1 161 3 2382 0.97784 0.23128 0.23128 25.0 289456 hsd17b11 HSD17B11_8832 22.4334 22.4334 22.4334 22.4334 18.1233 18.1233 18.1233 18.1233 29.2247 29.2247 29.2247 29.224700000000002 0.0 22.4334 0.0 22.4334 22.4334 18.1233 29.2247 1 0 1 289456 HSD17B11_8832 22.4334 22.4334 18.1233 18.1233 29.2247 29.2247 22.4334 18.1233 29.2247 0 0 Linear,1(1) 1.8952336311340332 1.8952336311340332 1.8952336311340332 1.8952336311340332 0.0 1.8952336311340332 22.4334 22.4334 18.1233 18.1233 29.2247 29.2247 UP 1.0 0.0 0.0 GO:0010632 5 regulation of epithelial cell migration 64 69 6 6 6 5 5 5 157 64 2321 0.72695 0.44996 0.8001 7.25 85253;24516;24471;24957;25112 plg;jun;hspb1;glul;gadd45a PLG_9501;JUN_8938;HSPB1_8847;GLUL_32832;GADD45A_8678 61.141020000000005 70.7857 16.4324 38.14885594243948 71.67432842319043 34.74456207215428 45.52626 46.2356 10.5224 31.53537118947547 54.051366140957704 30.430344205693807 89.50266 106.138 35.4303 50.15229734945349 102.69554967473742 45.8556457278564 2.5 79.9434 70.7857;16.4324;89.1011;26.4669;102.919 46.2356;10.5224;60.3265;21.0456;89.5012 150.579;39.929;106.138;35.4303;115.437 0 5 0 5 85253;24516;24471;24957;25112 PLG_9501;JUN_8938;HSPB1_8847;GLUL_32832;GADD45A_8678 61.141020000000005 70.7857 38.14885594243948 45.52626 46.2356 31.53537118947547 89.50266 106.138 50.15229734945349 70.7857;16.4324;89.1011;26.4669;102.919 46.2356;10.5224;60.3265;21.0456;89.5012 150.579;39.929;106.138;35.4303;115.437 0 Linear,2(0.4);Poly 2,3(0.6) 1.816414675989677 9.197522044181824 1.5254690647125244 2.3622660636901855 0.3367801633076976 1.6973176002502441 27.702073420752548 94.57996657924747 17.88428839926062 73.16823160073938 45.542233128345075 133.46308687165492 DOWN 0.0 1.0 0.0 GO:0048609 3 multicellular organismal reproductive process 128 145 13 13 12 12 11 11 151 134 2251 0.79259 0.31437 0.48492 7.59 25106;29540;24464;29328;294515;24890;24330;25146;29184;50681;312382 rgn;hsd17b7;hp;gpx4;foxo3;esr1;egr1;cyp17a1;cd36;acox1;abcg2 RGN_9699;HSD17B7_8834;HP_8823;GPX4_32827;FOXO3_8662;ESR1_33192;EGR1_8533;CYP17A1_32365;CD36_8243;ACOX1_7973;ABCG2_32656 32.076586454545456 23.3972 0.750017 26.60343794323716 34.77307540888045 28.140065228652002 22.847734636363636 18.3088 0.186019 19.839834342058627 24.813097526468457 20.696905172108195 51.562000000000005 33.4539 4.70178 41.5195777726325 56.66095004258008 46.37612733353757 6.5 47.025000000000006 77.4407;0.977494;64.9285;45.9204;13.1992;23.3972;0.750017;49.6922;48.1296;23.1906;5.21654 58.7732;0.322682;41.6103;34.2198;5.6804;18.3088;0.186019;35.6654;37.5433;16.2815;2.73368 89.8047;5.49472;136.455;70.4292;32.7581;31.9156;4.70178;81.6409;69.1421;33.4539;11.386 6 5 6 25106;29328;25146;29184;50681;312382 RGN_9699;GPX4_32827;CYP17A1_32365;CD36_8243;ACOX1_7973;ABCG2_32656 41.59834 47.025000000000006 24.795173574903654 30.86948 34.9426 19.296711419824884 59.30946666666667 69.78565 30.378118122929624 77.4407;45.9204;49.6922;48.1296;23.1906;5.21654 58.7732;34.2198;35.6654;37.5433;16.2815;2.73368 89.8047;70.4292;81.6409;69.1421;33.4539;11.386 5 29540;24464;294515;24890;24330 HSD17B7_8834;HP_8823;FOXO3_8662;ESR1_33192;EGR1_8533 20.6504822 13.1992 26.488978393323045 13.221640200000001 5.6804 17.4998289030222 42.26504 31.9156 54.388179588971354 0.977494;64.9285;13.1992;23.3972;0.750017 0.322682;41.6103;5.6804;18.3088;0.186019 5.49472;136.455;32.7581;31.9156;4.70178 0 Exp 2,4(0.37);Exp 4,3(0.28);Hill,1(0.1);Linear,1(0.1);Poly 2,1(0.1);Power,1(0.1) 2.237555491778269 27.330224871635437 1.5074360370635986 5.973292827606201 1.396750704736925 1.90940523147583 16.354959299018645 47.79821361007225 11.12314178416223 34.572327488565044 27.025497507766172 76.0985024922338 CONFLICT 0.5454545454545454 0.45454545454545453 0.0 GO:0071375 6 cellular response to peptide hormone stimulus 102 109 23 22 16 19 13 13 149 96 2289 0.99204 0.018827 0.024596 11.93 286954;246273;29441;24651;25513;25591;25661;29496;24330;497840;29184;25698;25373 ugt2b1;trib3;por;pklr;pik3r1;parp1;fn1;erbb3;egr1;cps1;cd36;ass1;ahsg UGT2B10_33303,UGT2B1_33224;TRIB3_10079;POR_9531;PKLR_9489;PIK3R1_32562;PARP1_9425;FN1_8655;ERBB3_8571;EGR1_8533;CPS1_32421;CD36_8243;ASS1_33159;AHSG_8003 36.725051307692304 26.9741 0.750017 28.35382032592576 38.095268879812764 25.601198203228584 26.483413769230772 21.799 0.186019 21.155031608475742 26.896156680268366 18.47720351620215 61.518433076923074 45.5891 4.70178 40.918672165409085 64.43258625039786 38.53254176684735 4.5 24.95 9.5 53.85365 47.47345;108.064;12.4414;23.0963;18.7324;26.9741;59.5777;60.9984;0.750017;31.9826;48.1296;26.8037;12.402 34.82915;83.8836;8.48981;17.4625;11.6701;21.799;31.0499;41.6036;0.186019;24.4836;37.5433;20.9825;10.3013 76.47475;143.428;79.2355;32.9443;41.5978;35.2797;105.243;113.972;4.70178;45.5891;69.1421;36.7081;15.4235 5 9 4 286954;25591;29496;29184 UGT2B10_33303,UGT2B1_33224;PARP1_9425;ERBB3_8571;CD36_8243 45.893887500000005 47.801525 14.066485997835107 33.9437625 36.186225 8.561716104202391 73.71713749999999 72.808425 32.282223959360245 47.47345;26.9741;60.9984;48.1296 34.82915;21.799;41.6036;37.5433 76.47475;35.2797;113.972;69.1421 9 246273;29441;24651;25513;25661;24330;497840;25698;25373 TRIB3_10079;POR_9531;PKLR_9489;PIK3R1_32562;FN1_8655;EGR1_8533;CPS1_32421;ASS1_33159;AHSG_8003 32.650013 23.0963 32.72603660800672 23.167703222222222 17.4625 24.568635390721656 56.09678666666667 41.5978 44.86903863396339 108.064;12.4414;23.0963;18.7324;59.5777;0.750017;31.9826;26.8037;12.402 83.8836;8.48981;17.4625;11.6701;31.0499;0.186019;24.4836;20.9825;10.3013 143.428;79.2355;32.9443;41.5978;105.243;4.70178;45.5891;36.7081;15.4235 0 Exp 2,8(0.58);Hill,1(0.08);Linear,1(0.08);Poly 2,3(0.22);Power,1(0.08) 2.104642330601846 30.8615460395813 1.6013026237487793 4.21828556060791 0.7800298932682204 1.851805865764618 21.31173900313692 52.1383636122477 14.983407588545797 37.98341994991574 39.2747895070834 83.76207664676274 DOWN 0.3076923076923077 0.6923076923076923 0.0 GO:2000146 6 negative regulation of cell motility 77 82 4 4 4 4 4 4 158 78 2307 0.39354 0.77783 0.81698 4.88 25106;83516;25112;294515 rgn;ppargc1a;gadd45a;foxo3 RGN_9699;PPARGC1A_33189;GADD45A_8678;FOXO3_8662 58.992075 59.92505 13.1992 39.33573021765115 73.68088160161004 34.896072545908716 45.0634 42.536 5.6804 36.81398098114356 58.77623293082467 34.594160597651516 79.932575 85.7676 32.7581 34.57690304440958 93.66706772442197 26.92156826223967 77.4407;42.4094;102.919;13.1992 58.7732;26.2988;89.5012;5.6804 89.8047;81.7305;115.437;32.7581 1 3 1 25106 RGN_9699 77.4407 77.4407 58.7732 58.7732 89.8047 89.8047 77.4407 58.7732 89.8047 3 83516;25112;294515 PPARGC1A_33189;GADD45A_8678;FOXO3_8662 52.842533333333336 42.4094 45.76077284501795 40.49346666666667 26.2988 43.67605808098222 76.64186666666667 81.7305 41.5736787908327 42.4094;102.919;13.1992 26.2988;89.5012;5.6804 81.7305;115.437;32.7581 0 Exp 2,1(0.25);Exp 4,1(0.25);Poly 2,2(0.5) 1.7702708025202847 7.099814414978027 1.6339634656906128 1.9883413314819336 0.151377309960931 1.7387548089027405 20.443059386701876 97.54109061329812 8.985698638479306 81.1411013615207 46.04721001647862 113.81793998352137 DOWN 0.25 0.75 0.0 GO:0051346 6 negative regulation of hydrolase activity 118 128 20 20 16 19 15 15 147 113 2272 0.99395 0.013938 0.023125 11.72 79224;24794;24648;25106;252922;29441;299282;288001;54404;50693;306251;83928;24360;25377;25373 serpind1;serpina3c;serpina1;rgn;pzp;por;loc299282;kng1;itih4;itih3;itih1;fetub;fabp1;ambp;ahsg SERPIND1_9812;SERPINA3C_32925;SERPINA1_9807;RGN_9699;PZP_9633;POR_9531;LOC299282_9119;KNG1L1_34113;ITIH4_32725;ITIH3_32422;ITIH1_33132;FETUB_33027;FABP1_33091;AMBP_33085;AHSG_8003 36.39167333333333 29.766 12.402 24.37263144267904 43.32854838935275 26.931396520620854 25.139294000000003 22.307 8.48981 13.479963368643425 28.12398674530793 14.167831213437163 53.622220000000006 46.9257 15.4235 29.667824155717422 65.2468621480054 29.62986002640671 5.5 27.69285 11.5 51.159000000000006 28.261;29.766;15.797;77.4407;34.1871;12.4414;45.2017;24.3655;57.1163;27.1247;98.1741;32.5155;33.8478;17.2343;12.402 22.307;23.347;13.013;58.7732;26.3085;8.48981;30.7472;19.538;39.6402;21.5108;42.9071;19.6094;26.4736;14.1233;10.3013 38.3264;40.8256;19.9134;89.8047;48.5666;79.2355;78.6415;32.1467;101.869;36.4819;104.278;49.9875;46.9257;21.9073;15.4235 2 13 2 25106;24360 RGN_9699;FABP1_33091 55.64425 55.64425 30.824835201587067 42.623400000000004 42.623400000000004 22.839266189613 68.3652 68.3652 30.32003167049796 77.4407;33.8478 58.7732;26.4736 89.8047;46.9257 13 79224;24794;24648;252922;29441;299282;288001;54404;50693;306251;83928;25377;25373 SERPIND1_9812;SERPINA3C_32925;SERPINA1_9807;PZP_9633;POR_9531;LOC299282_9119;KNG1L1_34113;ITIH4_32725;ITIH3_32422;ITIH1_33132;FETUB_33027;AMBP_33085;AHSG_8003 33.42973846153846 28.261 23.29307595608397 22.449431538461543 21.5108 10.475575114503133 51.35406923076924 40.8256 30.14081288990019 28.261;29.766;15.797;34.1871;12.4414;45.2017;24.3655;57.1163;27.1247;98.1741;32.5155;17.2343;12.402 22.307;23.347;13.013;26.3085;8.48981;30.7472;19.538;39.6402;21.5108;42.9071;19.6094;14.1233;10.3013 38.3264;40.8256;19.9134;48.5666;79.2355;78.6415;32.1467;101.869;36.4819;104.278;49.9875;21.9073;15.4235 0 Exp 2,5(0.34);Exp 3,1(0.07);Linear,6(0.4);Poly 2,3(0.2) 1.9010006085803048 29.38462483882904 1.5197933912277222 3.431420087814331 0.5505698656471675 1.7033517360687256 24.057420031049052 48.72592663561764 18.317491311792377 31.961096688207622 38.60822945388831 68.63621054611171 DOWN 0.13333333333333333 0.8666666666666667 0.0 GO:0010628 7 positive regulation of gene expression 455 488 38 38 29 31 25 25 137 463 1922 0.12519 0.91413 0.25599 5.12 79426;24825;293615;83516;25513;81819;25591;25493;24539;58954;24516;494344;63868;24471;290556;294515;314322;25661;24890;29496;65030;24330;65210;25695;29184 zfp36;tf;sirt3;ppargc1a;pik3r1;pax8;parp1;nfkbia;lpl;klf6;jun;ier2;hspd1;hspb1;gnl3;foxo3;fos;fn1;esr1;erbb3;ephx2;egr1;cyp2j4;cebpd;cd36 ZFP36_10204;TF_10003;SIRT3_9828;PPARGC1A_33189;PIK3R1_32562;PAX8_9432;PARP1_9425;NFKBIA_9307;LPL_32544;KLF6_8969;JUN_8938;IER2_32643;HSPD1_8849;HSPB1_8847;GNL3_8735;FOXO3_8662;FOS_8657;FN1_8655;ESR1_33192;ERBB3_8571;EPHX2_33282;EGR1_8533;CYP2J4_32580;CEBPD_8283;CD36_8243 33.38397672000005 26.9741 1.28141E-12 27.712906858183057 39.21230864903616 26.043410022358724 22.255689888000052 21.799 1.28141E-12 18.612729212106686 26.416661728254564 17.6748489395531 61.268274000000055 45.5481 1.28142E-12 56.18476752665294 67.27333356196897 46.94569818230416 23.5 88.36840000000001 0.348134;45.1539;2.38018;42.4094;18.7324;56.8931;26.9741;0.520151;74.2041;18.9476;16.4324;49.6814;42.2579;89.1011;87.6357;13.1992;1.28141E-12;59.5777;23.3972;60.9984;38.7293;0.750017;17.8395;0.306936;48.1296 0.118102;28.132;0.56209;26.2988;11.6701;45.1162;21.799;0.160202;49.8682;11.6941;10.5224;33.4626;23.9469;60.3265;54.41;5.6804;1.28141E-12;31.0499;18.3088;41.6036;29.2097;0.186019;14.6501;0.0732342;37.5433 1.15962;61.5341;8.82917;81.7305;41.5978;81.5688;35.2797;2.88499;155.425;45.5481;39.929;89.4404;102.383;106.138;238.963;32.7581;1.28142E-12;105.243;31.9156;113.972;57.2113;4.70178;22.6149;1.73689;69.1421 11 14 11 24825;293615;81819;25591;24539;63868;290556;29496;65030;65210;29184 TF_10003;SIRT3_9828;PAX8_9432;PARP1_9425;LPL_32544;HSPD1_8849;GNL3_8735;ERBB3_8571;EPHX2_33282;CYP2J4_32580;CD36_8243 45.563252727272726 45.1539 24.495552599706382 31.531008181818184 29.2097 16.109234708164642 86.08391545454546 69.1421 65.98864946375268 45.1539;2.38018;56.8931;26.9741;74.2041;42.2579;87.6357;60.9984;38.7293;17.8395;48.1296 28.132;0.56209;45.1162;21.799;49.8682;23.9469;54.41;41.6036;29.2097;14.6501;37.5433 61.5341;8.82917;81.5688;35.2797;155.425;102.383;238.963;113.972;57.2113;22.6149;69.1421 14 79426;83516;25513;25493;58954;24516;494344;24471;294515;314322;25661;24890;24330;25695 ZFP36_10204;PPARGC1A_33189;PIK3R1_32562;NFKBIA_9307;KLF6_8969;JUN_8938;IER2_32643;HSPB1_8847;FOXO3_8662;FOS_8657;FN1_8655;ESR1_33192;EGR1_8533;CEBPD_8283 23.81454557142866 17.5824 27.05846292368549 14.967939800000094 11.09625 17.60556961202388 41.770270000000096 36.34355 39.34078815007131 0.348134;42.4094;18.7324;0.520151;18.9476;16.4324;49.6814;89.1011;13.1992;1.28141E-12;59.5777;23.3972;0.750017;0.306936 0.118102;26.2988;11.6701;0.160202;11.6941;10.5224;33.4626;60.3265;5.6804;1.28141E-12;31.0499;18.3088;0.186019;0.0732342 1.15962;81.7305;41.5978;2.88499;45.5481;39.929;89.4404;106.138;32.7581;1.28142E-12;105.243;31.9156;4.70178;1.73689 0 Exp 2,8(0.32);Exp 3,1(0.04);Exp 4,2(0.08);Hill,5(0.2);Linear,3(0.12);Poly 2,5(0.2);Power,1(0.04) 2.01637006880927 53.218510150909424 1.5209722518920898 4.642963409423828 0.8432005633076537 1.8086696863174438 22.520517231592297 44.24743620840782 14.95950003685423 29.551879739145868 39.2438451295521 83.29270287044801 CONFLICT 0.44 0.56 0.0 GO:0022904 5 respiratory electron transport chain 14 16 3 3 3 3 3 3 159 13 2372 0.98429 0.076773 0.076773 18.75 83516;303612;295143 ppargc1a;polg2;etfdh PPARGC1A_33189;POLG2_9521;ETFDH_8575 41.4361 42.4094 18.1231 22.841907516448778 42.48684097747291 21.050092284457776 27.374366666666663 26.2988 14.869 13.07636779321129 27.737495517967105 12.125171648071998 79.10260000000001 81.7305 23.0103 54.82560553728524 81.66664118013875 50.5153704678535 0.0 18.1231 0.5 30.26625 42.4094;63.7758;18.1231 26.2988;40.9553;14.869 81.7305;132.567;23.0103 1 2 1 295143 ETFDH_8575 18.1231 18.1231 14.869 14.869 23.0103 23.0103 18.1231 14.869 23.0103 2 83516;303612 PPARGC1A_33189;POLG2_9521 53.0926 53.0926 15.108326329544246 33.62705 33.62705 10.363710538460639 107.14875 107.14875 35.946833881789956 42.4094;63.7758 26.2988;40.9553 81.7305;132.567 0 Exp 2,2(0.67);Linear,1(0.34) 1.68980199038137 5.078686594963074 1.5504547357559204 1.7706087827682495 0.12352810366209484 1.7576230764389038 15.588048351284552 67.28415164871544 12.577063514417814 42.17166981891551 17.06158689374572 141.1436131062543 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0010811 7 positive regulation of cell-substrate adhesion 40 43 5 5 2 3 2 2 160 41 2344 0.47779 0.77022 1.0 4.65 25661;29184 fn1;cd36 FN1_8655;CD36_8243 53.85365 53.85365 48.1296 8.095029141701673 54.16761716667552 8.082842695580569 34.2966 34.2966 31.0499 4.591527172956761 34.1185167896777 4.584614980606589 87.19255 87.19255 69.1421 25.527191196937412 88.18262671905697 25.48876196651704 59.5777;48.1296 31.0499;37.5433 105.243;69.1421 1 1 1 29184 CD36_8243 48.1296 48.1296 37.5433 37.5433 69.1421 69.1421 48.1296 37.5433 69.1421 1 25661 FN1_8655 59.5777 59.5777 31.0499 31.0499 105.243 105.243 59.5777 31.0499 105.243 0 Exp 2,1(0.5);Power,1(0.5) 2.179703309235084 4.449544310569763 1.7792335748672485 2.6703107357025146 0.6300867029870725 2.2247721552848816 42.63451200000001 65.072788 27.933068 40.660132 51.81366800000001 122.57143199999999 CONFLICT 0.5 0.5 0.0 GO:0071705 5 nitrogen compound transport 239 254 21 20 17 18 15 15 147 239 2146 0.44177 0.6637 0.89213 5.91 79426;171139;361074;29482;297784;308821;25513;25493;63868;24471;85255;114851;29184;65054;312382 zfp36;timm9;slc25a30;slc1a2;rrs1;rab30;pik3r1;nfkbia;hspd1;hspb1;hacl1;cdkn1a;cd36;aqp9;abcg2 ZFP36_10204;TIMM9_10020;SLC25A30_9856;SLC1A2_33059;RRS1_9755;RAB30_9639;PIK3R1_32562;NFKBIA_9307;HSPD1_8849;HSPB1_8847;HACL1_8775;CDKN1A_8271;CD36_8243;AQP9_32709;ABCG2_32656 171139(0.04986) 29.83869966666667 26.4203 0.348134 25.35450005784019 33.44517726097913 26.69659894926036 20.82217693333333 21.0125 0.118102 17.999799465476052 23.124235737677658 19.03078358051403 49.30475400000001 37.6534 1.15962 37.04569771084543 55.171744951196736 37.54604864159062 11.5 50.5713 0.348134;38.5191;53.013;13.3235;60.39;26.4203;18.7324;0.520151;42.2579;89.1011;17.6275;6.24967;48.1296;27.7316;5.21654 0.118102;29.55;37.4804;9.10952;43.109;21.0125;11.6701;0.160202;23.9469;60.3265;11.195;2.44025;37.5433;21.9372;2.73368 1.15962;55.4685;90.2594;24.6773;104.942;35.3561;41.5978;2.88499;102.383;106.138;37.6534;19.0606;69.1421;37.4625;11.386 8 7 8 171139;361074;297784;308821;63868;85255;29184;312382 TIMM9_10020;SLC25A30_9856;RRS1_9755;RAB30_9639;HSPD1_8849;HACL1_8775;CD36_8243;ABCG2_32656 36.446742500000006 40.3885 18.717038950039793 25.8213475 26.74845 13.937167438832399 63.323812499999995 62.3053 34.26259377327815 38.5191;53.013;60.39;26.4203;42.2579;17.6275;48.1296;5.21654 29.55;37.4804;43.109;21.0125;23.9469;11.195;37.5433;2.73368 55.4685;90.2594;104.942;35.3561;102.383;37.6534;69.1421;11.386 7 79426;29482;25513;25493;24471;114851;65054 ZFP36_10204;SLC1A2_33059;PIK3R1_32562;NFKBIA_9307;HSPB1_8847;CDKN1A_8271;AQP9_32709 22.286650714285713 13.3235 31.088724244248787 15.108839142857144 9.10952 21.399989197205148 33.28297285714286 24.6773 35.65281763787949 0.348134;13.3235;18.7324;0.520151;89.1011;6.24967;27.7316 0.118102;9.10952;11.6701;0.160202;60.3265;2.44025;21.9372 1.15962;24.6773;41.5978;2.88499;106.138;19.0606;37.4625 0 Exp 2,3(0.2);Exp 3,1(0.07);Exp 4,3(0.2);Hill,1(0.07);Linear,3(0.2);Poly 2,4(0.27) 1.9806547138733377 30.767516016960144 1.5074360370635986 3.648852586746216 0.6129585547420634 1.8171201944351196 17.007552287210473 42.66984704612286 11.713021587524715 29.931332279141962 30.557044283055482 68.05246371694452 CONFLICT 0.5333333333333333 0.4666666666666667 0.0 GO:0030030 5 cell projection organization 158 167 6 6 3 6 3 3 159 164 2221 0.0043885 0.99899 0.0080166 1.8 308843;24516;29496 tsku;jun;erbb3 TSKU_10094;JUN_8938;ERBB3_8571 26.271653333333333 16.4324 1.38416 31.001170660356248 37.18712300102076 31.212627483978164 17.555522666666665 10.5224 0.540568 21.415923050187246 25.085969775433824 21.616240404120596 52.66990666666666 39.929 4.10872 56.02885952887256 72.53862029601905 55.21338404439682 1.38416;16.4324;60.9984 0.540568;10.5224;41.6036 4.10872;39.929;113.972 1 2 1 29496 ERBB3_8571 60.9984 60.9984 41.6036 41.6036 113.972 113.972 60.9984 41.6036 113.972 2 308843;24516 TSKU_10094;JUN_8938 8.908280000000001 8.908280000000001 10.640712548922652 5.531484 5.531484 7.0582210958648774 22.01886 22.01886 25.328762892000867 1.38416;16.4324 0.540568;10.5224 4.10872;39.929 0 Hill,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 2.1122092070952956 6.554213047027588 1.6013026237487793 2.9744045734405518 0.7094018026586832 1.9785058498382568 -8.809473749529083 61.35278041619575 -6.678875651754371 41.789920985087704 -10.73271651084265 116.07252984417597 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0006207 8 'de novo' pyrimidine nucleobase biosynthetic process 1 1 1 1 1 1 1 1 161 0 2385 1.0 0.063604 0.063604 100.0 497840 cps1 CPS1_32421 31.9826 31.9826 31.9826 31.9826 24.4836 24.4836 24.4836 24.4836 45.5891 45.5891 45.5891 45.5891 0.0 31.9826 0.0 31.9826 31.9826 24.4836 45.5891 0 1 0 1 497840 CPS1_32421 31.9826 31.9826 24.4836 24.4836 45.5891 45.5891 31.9826 24.4836 45.5891 0 Exp 2,1(1) 1.8264755010604858 1.8264755010604858 1.8264755010604858 1.8264755010604858 0.0 1.8264755010604858 31.9826 31.9826 24.4836 24.4836 45.5891 45.5891 DOWN 0.0 1.0 0.0 GO:1904486 5 response to 17alpha-ethynylestradiol 6 6 2 2 2 2 2 2 160 4 2381 0.99562 0.050905 0.050905 33.33 170698;25303 slco1a2;abcc2 SLCO1A2_9886;ABCC2_32541 75.21430000000001 75.21430000000001 46.2316 40.987727414190665 60.11524822580645 34.98615539924966 55.74445 55.74445 31.1788 34.74107539851063 42.94653879032258 29.654160874714137 105.0984 105.0984 81.7848 32.97040930774137 92.95276645161292 28.142762148314194 0.0 46.2316 0.0 46.2316 104.197;46.2316 80.3101;31.1788 128.412;81.7848 0 2 0 2 170698;25303 SLCO1A2_9886;ABCC2_32541 75.21430000000001 75.21430000000001 40.987727414190665 55.74445 55.74445 34.74107539851063 105.0984 105.0984 32.97040930774137 104.197;46.2316 80.3101;31.1788 128.412;81.7848 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.714190212497765 3.4396555423736572 1.5806894302368164 1.8589661121368408 0.19677132881759907 1.7198277711868286 18.408208000000016 132.02039200000002 7.5957759999999865 103.89312400000001 59.403743999999996 150.793056 DOWN 0.0 1.0 0.0 GO:0031327 7 negative regulation of cellular biosynthetic process 281 294 24 24 19 21 17 17 145 277 2108 0.39034 0.70497 0.79918 5.78 79426;24522;246273;25106;25591;24516;25112;294515;24890;116636;24330;25428;25695;114851;29184;79431;25287 zfp36;zfp354a;trib3;rgn;parp1;jun;gadd45a;foxo3;esr1;eif4ebp1;egr1;cyp7a1;cebpd;cdkn1a;cd36;bhlhe40;acadl ZFP36_10204;ZFP354A_10203;TRIB3_10079;RGN_9699;PARP1_9425;JUN_8938;GADD45A_8678;FOXO3_8662;ESR1_33192;EIF4EBP1_8550;EGR1_8533;CYP7A1_8430;CEBPD_8283;CDKN1A_8271;CD36_8243;BHLHE40_8141;ACADL_32776 35.644909647058824 23.3972 0.306936 37.31552820597846 38.267443341211475 39.61022484101876 25.732778129411763 18.3088 0.0732342 29.146098788077854 28.327065862221666 31.481072744018267 51.34923294117647 35.2797 1.15962 45.78985043014264 51.77740827412275 46.71229379944376 13.5 80.6704 0.348134;0.834827;108.064;77.4407;26.9741;16.4324;102.919;13.1992;23.3972;83.9001;0.750017;5.72128;0.306936;6.24967;48.1296;57.8085;33.4878 0.118102;0.27095;83.8836;58.7732;21.799;10.5224;89.5012;5.6804;18.3088;42.4185;0.186019;0.985273;0.0732342;2.44025;37.5433;38.3491;26.6039 1.15962;2.99857;143.428;89.8047;35.2797;39.929;115.437;32.7581;31.9156;107.32;4.70178;22.3625;1.73689;19.0606;69.1421;110.58;45.3228 5 12 5 25106;25591;116636;29184;25287 RGN_9699;PARP1_9425;EIF4EBP1_8550;CD36_8243;ACADL_32776 53.98646 48.1296 25.637339446849776 37.42758 37.5433 14.508297008160545 69.37386 69.1421 29.992697902706276 77.4407;26.9741;83.9001;48.1296;33.4878 58.7732;21.799;42.4185;37.5433;26.6039 89.8047;35.2797;107.32;69.1421;45.3228 12 79426;24522;246273;24516;25112;294515;24890;24330;25428;25695;114851;79431 ZFP36_10204;ZFP354A_10203;TRIB3_10079;JUN_8938;GADD45A_8678;FOXO3_8662;ESR1_33192;EGR1_8533;CYP7A1_8430;CEBPD_8283;CDKN1A_8271;BHLHE40_8141 28.002596999999998 9.724435 39.61997197364282 20.859944016666663 4.060325 32.726389634050726 43.83897166666666 27.13905 50.13421489336958 0.348134;0.834827;108.064;16.4324;102.919;13.1992;23.3972;0.750017;5.72128;0.306936;6.24967;57.8085 0.118102;0.27095;83.8836;10.5224;89.5012;5.6804;18.3088;0.186019;0.985273;0.0732342;2.44025;38.3491 1.15962;2.99857;143.428;39.929;115.437;32.7581;31.9156;4.70178;22.3625;1.73689;19.0606;110.58 0 Exp 2,5(0.3);Exp 3,1(0.06);Exp 4,2(0.12);Hill,5(0.3);Poly 2,4(0.24) 2.177720430536868 39.83585548400879 1.522104263305664 4.591650485992432 1.0509731743690938 1.8872262239456177 17.90623353134294 53.38358576277471 11.877602247014917 39.58795401180862 29.582119752162576 73.11634613019038 DOWN 0.29411764705882354 0.7058823529411765 0.0 GO:0071310 5 cellular response to organic substance 516 551 60 59 45 53 40 40 122 511 1874 0.85849 0.18884 0.32506 7.26 79426;286954;246273;24825;83516;29441;24651;25513;81819;25591;81525;25493;24539;89783;58954;24516;81678;63868;24471;81869;294515;314322;25661;361969;24890;29496;25315;116636;24330;140942;25428;25146;497840;113936;29184;25698;65054;25373;312382;25303 zfp36;ugt2b1;trib3;tf;ppargc1a;por;pklr;pik3r1;pax8;parp1;nfkbib;nfkbia;lpl;laptm5;klf6;jun;itpr2;hspd1;hspb1;gstm7;foxo3;fos;fn1;fga;esr1;erbb3;ephx1;eif4ebp1;egr1;ddit4;cyp7a1;cyp17a1;cps1;cpb2;cd36;ass1;aqp9;ahsg;abcg2;abcc2 ZFP36_10204;UGT2B10_33303,UGT2B1_33224;TRIB3_10079;TF_10003;PPARGC1A_33189;POR_9531;PKLR_9489;PIK3R1_32562;PAX8_9432;PARP1_9425;NFKBIB_9308;NFKBIA_9307;LPL_32544;LAPTM5_32639;KLF6_8969;JUN_8938;ITPR2_8931;HSPD1_8849;HSPB1_8847;GSTM7_8761;FOXO3_8662;FOS_8657;FN1_8655;FGA_8632;ESR1_33192;ERBB3_8571;EPHX1_8567;EIF4EBP1_8550;EGR1_8533;DDIT4_8450;CYP7A1_8430;CYP17A1_32365;CPS1_32421;CPB2_8369;CD36_8243;ASS1_33159;AQP9_32709;AHSG_8003;ABCG2_32656;ABCC2_32541 35.41423430000003 29.56875 1.28141E-12 26.641265015032022 39.16894243729199 25.34854562088149 24.190019650000036 23.237949999999998 1.28141E-12 18.292351255622634 26.790959661277896 17.153135019723862 61.219271000000035 44.93885 1.28142E-12 48.44212552528402 65.28672985845124 42.71407638678378 26.5 43.78165 0.348134;47.47345;108.064;45.1539;42.4094;12.4414;23.0963;18.7324;56.8931;26.9741;30.5572;0.520151;74.2041;38.674;18.9476;16.4324;31.8111;42.2579;89.1011;42.3152;13.1992;1.28141E-12;59.5777;28.5803;23.3972;60.9984;12.4747;83.9001;0.750017;87.5421;5.72128;49.6922;31.9826;25.8316;48.1296;26.8037;27.7316;12.402;5.21654;46.2316 0.118102;34.82915;83.8836;28.132;26.2988;8.48981;17.4625;11.6701;45.1162;21.799;24.2439;0.160202;49.8682;24.6273;11.6941;10.5224;24.7342;23.9469;60.3265;31.4035;5.6804;1.28141E-12;31.0499;22.529;18.3088;41.6036;7.00435;42.4185;0.186019;53.2453;0.985273;35.6654;24.4836;20.4374;37.5433;20.9825;21.9372;10.3013;2.73368;31.1788 1.15962;76.47475;143.428;61.5341;81.7305;79.2355;32.9443;41.5978;81.5688;35.2797;41.2611;2.88499;155.425;71.0786;45.5481;39.929;44.3296;102.383;106.138;64.5991;32.7581;1.28142E-12;105.243;38.8511;31.9156;113.972;23.684;107.32;4.70178;245.492;22.3625;81.6409;45.5891;34.8042;69.1421;36.7081;37.4625;15.4235;11.386;81.7848 15 26 14 286954;24825;81819;25591;81525;24539;63868;81869;29496;25315;116636;25146;29184;312382 UGT2B10_33303,UGT2B1_33224;TF_10003;PAX8_9432;PARP1_9425;NFKBIB_9308;LPL_32544;HSPD1_8849;GSTM7_8761;ERBB3_8571;EPHX1_8567;EIF4EBP1_8550;CYP17A1_32365;CD36_8243;ABCG2_32656 44.73146357142857 46.313675 21.464297215600958 30.450548571428566 33.116325 13.68976294615341 73.26218214285714 72.808425 38.777934400177436 47.47345;45.1539;56.8931;26.9741;30.5572;74.2041;42.2579;42.3152;60.9984;12.4747;83.9001;49.6922;48.1296;5.21654 34.82915;28.132;45.1162;21.799;24.2439;49.8682;23.9469;31.4035;41.6036;7.00435;42.4185;35.6654;37.5433;2.73368 76.47475;61.5341;81.5688;35.2797;41.2611;155.425;102.383;64.5991;113.972;23.684;107.32;81.6409;69.1421;11.386 26 79426;246273;83516;29441;24651;25513;25493;89783;58954;24516;81678;24471;294515;314322;25661;361969;24890;24330;140942;25428;497840;113936;25698;65054;25373;25303 ZFP36_10204;TRIB3_10079;PPARGC1A_33189;POR_9531;PKLR_9489;PIK3R1_32562;NFKBIA_9307;LAPTM5_32639;KLF6_8969;JUN_8938;ITPR2_8931;HSPB1_8847;FOXO3_8662;FOS_8657;FN1_8655;FGA_8632;ESR1_33192;EGR1_8533;DDIT4_8450;CYP7A1_8430;CPS1_32421;CPB2_8369;ASS1_33159;AQP9_32709;AHSG_8003;ABCC2_32541 30.397264692307736 24.614400000000003 28.15773009648595 20.818965615384663 19.3731 19.767939992769513 54.734626538461576 39.39005 52.47731512060292 0.348134;108.064;42.4094;12.4414;23.0963;18.7324;0.520151;38.674;18.9476;16.4324;31.8111;89.1011;13.1992;1.28141E-12;59.5777;28.5803;23.3972;0.750017;87.5421;5.72128;31.9826;25.8316;26.8037;27.7316;12.402;46.2316 0.118102;83.8836;26.2988;8.48981;17.4625;11.6701;0.160202;24.6273;11.6941;10.5224;24.7342;60.3265;5.6804;1.28141E-12;31.0499;22.529;18.3088;0.186019;53.2453;0.985273;24.4836;20.4374;20.9825;21.9372;10.3013;31.1788 1.15962;143.428;81.7305;79.2355;32.9443;41.5978;2.88499;71.0786;45.5481;39.929;44.3296;106.138;32.7581;1.28142E-12;105.243;38.8511;31.9156;4.70178;245.492;22.3625;45.5891;34.8042;36.7081;37.4625;15.4235;81.7848 0 Exp 2,16(0.4);Exp 3,2(0.05);Exp 4,3(0.08);Hill,5(0.13);Linear,7(0.18);Poly 2,7(0.18);Power,1(0.03) 1.9405440025012046 82.56462895870209 1.5074360370635986 4.560328960418701 0.6625228113067687 1.8171201944351196 27.15802073482525 43.67044786517484 18.5211612646944 29.858878035305658 46.2069007667516 76.23164123324851 DOWN 0.35 0.65 0.0 GO:0072521 5 purine-containing compound metabolic process 83 95 27 27 17 23 15 15 147 80 2305 0.99977 7.429E-4 7.429E-4 15.79 24856;360268;298490;24651;294103;100359982;25675;83842;25028;192272;170570;50559;170465;312382;296925 ttr;sult1e1;ppcs;pklr;papss2;mpc2;hmgcr;crot;ampd1;acot2;acot12;acot1;acaa2;abcg2;aass TTR_10102;SULT1E1_32446;PPCS_9540;PKLR_9489;PAPSS2_33237;MPC2_33219;HMGCR_8810;CROT_8384;AMPD1_32743;ACOT2_7969;ACOT12_32718;ACOT1_7968;ACAA2_7955;ABCG2_32656;AASS_7936 28.057798666666663 27.4644 1.63089 17.800448744841436 31.017017786622553 16.550734766558552 21.41937646666667 21.7498 0.663137 13.699185761866497 23.783317924144523 12.895859783516203 39.75916 37.0295 7.6286 25.28818434952237 43.120492649643325 23.334303972236544 3.5 14.442174999999999 8.5 30.77205 46.6406;50.1846;20.3353;23.0963;34.4443;46.8463;1.63089;7.4229;60.9045;8.54905;30.3423;31.2018;26.5872;5.21654;27.4644 28.5876;36.5009;16.7643;17.4625;25.719;35.8494;0.663137;5.75707;50.0633;7.19676;24.0157;26.858;21.3695;2.73368;21.7498 63.7146;80.9788;25.6711;32.9443;51.1014;69.127;7.6286;10.316;82.6625;10.4125;41.1025;37.2719;35.0407;11.386;37.0295 12 3 12 24856;360268;298490;100359982;83842;25028;192272;170570;50559;170465;312382;296925 TTR_10102;SULT1E1_32446;PPCS_9540;MPC2_33219;CROT_8384;AMPD1_32743;ACOT2_7969;ACOT12_32718;ACOT1_7968;ACAA2_7955;ABCG2_32656;AASS_7936 30.14129083333333 28.903350000000003 18.14113109626122 23.120500833333335 22.88275 13.907671746541032 42.059425000000005 37.1507 26.426459722204893 46.6406;50.1846;20.3353;46.8463;7.4229;60.9045;8.54905;30.3423;31.2018;26.5872;5.21654;27.4644 28.5876;36.5009;16.7643;35.8494;5.75707;50.0633;7.19676;24.0157;26.858;21.3695;2.73368;21.7498 63.7146;80.9788;25.6711;69.127;10.316;82.6625;10.4125;41.1025;37.2719;35.0407;11.386;37.0295 3 24651;294103;25675 PKLR_9489;PAPSS2_33237;HMGCR_8810 19.72383 23.0963 16.664637241257306 14.614879 17.4625 12.768350586055469 30.558099999999996 32.9443 21.834412009257317 23.0963;34.4443;1.63089 17.4625;25.719;0.663137 32.9443;51.1014;7.6286 0 Exp 2,9(0.6);Exp 4,2(0.14);Linear,2(0.14);Poly 2,2(0.14) 3.352734884321604 385.8565157651901 1.5074360370635986 344.14306640625 88.12897956411393 1.9248499870300293 19.049528704944834 37.0660686283885 14.486631940524736 28.3521209928086 26.961572999374305 52.5567470006257 UP 0.8 0.2 0.0 GO:0002831 5 regulation of response to biotic stimulus 69 73 3 3 2 3 2 2 160 71 2314 0.14534 0.95304 0.32413 2.74 65164;63868 htra1;hspd1 HTRA1_8856;HSPD1_8849 37.6951 37.6951 33.1323 6.452773642395981 37.22954914545588 6.419097482019311 24.7807 24.7807 23.9469 1.1791712683066462 24.865774143622094 1.1730173315745092 74.52295 74.52295 46.6629 39.40006055839254 71.68033798870387 39.19443692555707 33.1323;42.2579 25.6145;23.9469 46.6629;102.383 1 1 1 63868 HSPD1_8849 42.2579 42.2579 23.9469 23.9469 102.383 102.383 42.2579 23.9469 102.383 1 65164 HTRA1_8856 33.1323 33.1323 25.6145 25.6145 46.6629 46.6629 33.1323 25.6145 46.6629 0 Exp 3,1(0.5);Linear,1(0.5) 1.8744560010243798 3.8121607303619385 1.5603101253509521 2.2518506050109863 0.4889929626326079 1.9060803651809692 28.752012 46.63818799999999 23.146452 26.414948 19.917252000000012 129.12864799999997 CONFLICT 0.5 0.5 0.0 GO:0006606 6 protein import into nucleus 22 23 4 4 3 4 3 3 159 20 2365 0.94591 0.17665 0.17665 13.04 25513;25493;114851 pik3r1;nfkbia;cdkn1a PIK3R1_32562;NFKBIA_9307;CDKN1A_8271 8.500740333333333 6.24967 0.520151 9.312464316372456 8.700175197488921 7.199621387025169 4.756850666666666 2.44025 0.160202 6.094621971804432 4.439148824815362 5.0440995643686115 21.18113 19.0606 2.88499 19.44332533633843 22.927640994091583 14.073576197146503 0.5 3.3849105 1.5 12.491035 18.7324;0.520151;6.24967 11.6701;0.160202;2.44025 41.5978;2.88499;19.0606 0 3 0 3 25513;25493;114851 PIK3R1_32562;NFKBIA_9307;CDKN1A_8271 8.500740333333333 6.24967 9.312464316372456 4.756850666666666 2.44025 6.094621971804432 21.18113 19.0606 19.44332533633843 18.7324;0.520151;6.24967 11.6701;0.160202;2.44025 41.5978;2.88499;19.0606 0 Exp 4,2(0.67);Poly 2,1(0.34) 1.6779571377698022 5.050290465354919 1.522104263305664 1.8546061515808105 0.16646965143185835 1.6735800504684448 -2.037305075224456 19.03878574189112 -2.139863339952714 11.653564673286049 -0.8210638690778751 43.183323869077874 DOWN 0.0 1.0 0.0 GO:2000027 6 regulation of animal organ morphogenesis 54 58 7 7 5 6 4 4 158 54 2331 0.69228 0.50986 0.78448 6.9 29441;81819;24890;113936 por;pax8;esr1;cpb2 POR_9531;PAX8_9432;ESR1_33192;CPB2_8369 29.640825 24.614400000000003 12.4414 19.078781942666918 35.58660618866182 23.868353005707984 23.088052500000003 19.3731 8.48981 15.5800639654771 27.70386820863642 19.58101410110884 56.88102500000001 57.019850000000005 31.9156 27.202128804485728 72.50374194088442 20.62772070190581 1.5 24.614400000000003 12.4414;56.8931;23.3972;25.8316 8.48981;45.1162;18.3088;20.4374 79.2355;81.5688;31.9156;34.8042 1 3 1 81819 PAX8_9432 56.8931 56.8931 45.1162 45.1162 81.5688 81.5688 56.8931 45.1162 81.5688 3 29441;24890;113936 POR_9531;ESR1_33192;CPB2_8369 20.556733333333334 23.3972 7.132710016069166 15.745336666666669 18.3088 6.372969080266532 48.651766666666674 34.8042 26.52563968961602 12.4414;23.3972;25.8316 8.48981;18.3088;20.4374 79.2355;31.9156;34.8042 0 Exp 2,3(0.75);Poly 2,1(0.25) 1.9071143041378722 7.7341978549957275 1.5630855560302734 2.436986207962036 0.37679389419571657 1.867063045501709 10.94361869618642 48.33803130381358 7.819589813832431 38.35651518616757 30.222938771603967 83.53911122839605 DOWN 0.25 0.75 0.0 GO:0001694 6 histamine biosynthetic process 1 1 1 1 1 1 1 1 161 0 2385 1.0 0.063604 0.063604 100.0 24443 hdc HDC_8788 24.5745 24.5745 24.5745 24.5745 21.0619 21.0619 21.0619 21.0619 29.28 29.28 29.28 29.28 0.0 24.5745 0.0 24.5745 24.5745 21.0619 29.28 1 0 1 24443 HDC_8788 24.5745 24.5745 21.0619 21.0619 29.28 29.28 24.5745 21.0619 29.28 0 0 Exp 2,1(1) 17.51306533813477 17.513065338134766 17.513065338134766 17.513065338134766 0.0 17.513065338134766 24.5745 24.5745 21.0619 21.0619 29.28 29.28 UP 1.0 0.0 0.0 GO:0048646 3 anatomical structure formation involved in morphogenesis 166 174 8 8 7 6 5 5 157 169 2216 0.027797 0.98974 0.052399 2.87 81819;24516;65164;24957;25661 pax8;jun;htra1;glul;fn1 PAX8_9432;JUN_8938;HTRA1_8856;GLUL_32832;FN1_8655 38.500479999999996 33.1323 16.4324 18.99448757145083 44.166873068320754 17.999866463015238 26.66972 25.6145 10.5224 12.776333192939207 29.820447925923713 11.790352690487927 61.7668 46.6629 35.4303 30.335324733468735 70.42195045179375 31.062527549241384 56.8931;16.4324;33.1323;26.4669;59.5777 45.1162;10.5224;25.6145;21.0456;31.0499 81.5688;39.929;46.6629;35.4303;105.243 1 4 1 81819 PAX8_9432 56.8931 56.8931 45.1162 45.1162 81.5688 81.5688 56.8931 45.1162 81.5688 4 24516;65164;24957;25661 JUN_8938;HTRA1_8856;GLUL_32832;FN1_8655 33.902325 29.799599999999998 18.441815206458575 22.0581 23.33005 8.71010866637151 56.8163 43.295950000000005 32.61277204685306 16.4324;33.1323;26.4669;59.5777 10.5224;25.6145;21.0456;31.0499 39.929;46.6629;35.4303;105.243 0 Exp 2,1(0.2);Linear,2(0.4);Poly 2,1(0.2);Power,1(0.2) 1.86783557792482 9.43251359462738 1.5603101253509521 2.3622660636901855 0.3044508894512312 1.7792335748672485 21.851077560244736 55.149882439755274 15.470770187141195 37.8686698128588 35.17671549636183 88.35688450363818 DOWN 0.2 0.8 0.0 GO:0048640 6 negative regulation of developmental growth 30 32 3 3 2 2 2 2 160 30 2355 0.66694 0.6142 1.0 6.25 29455;114851 gdf15;cdkn1a GDF15_33113;CDKN1A_8271 55.699335 55.699335 6.24967 69.93238689780617 49.82491901853464 69.4371745607341 43.894475 43.894475 2.44025 58.62512721266581 38.96988427043164 58.20998499393165 72.3563 72.3563 19.0606 75.37150175616776 66.02499094414728 74.83777340527013 0.5 55.699335 105.149;6.24967 85.3487;2.44025 125.652;19.0606 0 2 0 2 29455;114851 GDF15_33113;CDKN1A_8271 55.699335 55.699335 69.93238689780617 43.894475 43.894475 58.62512721266581 72.3563 72.3563 75.37150175616776 105.149;6.24967 85.3487;2.44025 125.652;19.0606 0 Exp 4,1(0.5);Poly 2,1(0.5) 1.5412407383863502 3.0827220678329468 1.522104263305664 1.5606178045272827 0.02723318616531418 1.5413610339164734 -41.222008399999986 152.62067839999997 -37.35580599999999 125.14475599999999 -32.103271999999976 176.81587199999998 DOWN 0.0 1.0 0.0 GO:0022414 2 reproductive process 343 368 33 33 26 29 22 22 140 346 2039 0.42619 0.66293 0.81792 5.98 360268;25106;252922;85253;65164;24471;29540;24464;29328;24384;294515;314322;83928;24890;24330;65210;25146;29184;25373;50681;312382;25303 sult1e1;rgn;pzp;plg;htra1;hspb1;hsd17b7;hp;gpx4;gc;foxo3;fos;fetub;esr1;egr1;cyp2j4;cyp17a1;cd36;ahsg;acox1;abcg2;abcc2 SULT1E1_32446;RGN_9699;PZP_9633;PLG_9501;HTRA1_8856;HSPB1_8847;HSD17B7_8834;HP_8823;GPX4_32827;GC_32893;FOXO3_8662;FOS_8657;FETUB_33027;ESR1_33192;EGR1_8533;CYP2J4_32580;CYP17A1_32365;CD36_8243;AHSG_8003;ACOX1_7973;ABCG2_32656;ABCC2_32541 35.526265954545515 33.6597 1.28141E-12 25.65726213091459 38.9808878649326 25.80498938248868 24.928312772727327 25.9615 1.28141E-12 18.044384420388095 27.144241094492944 17.91299882096241 56.75801363636369 49.27705 1.28142E-12 41.85241299991389 62.86662753738885 43.82237800691405 17.5 57.55655 50.1846;77.4407;34.1871;70.7857;33.1323;89.1011;0.977494;64.9285;45.9204;42.356;13.1992;1.28141E-12;32.5155;23.3972;0.750017;17.8395;49.6922;48.1296;12.402;23.1906;5.21654;46.2316 36.5009;58.7732;26.3085;46.2356;25.6145;60.3265;0.322682;41.6103;34.2198;26.3722;5.6804;1.28141E-12;19.6094;18.3088;0.186019;14.6501;35.6654;37.5433;10.3013;16.2815;2.73368;31.1788 80.9788;89.8047;48.5666;150.579;46.6629;106.138;5.49472;136.455;70.4292;78.7583;32.7581;1.28142E-12;49.9875;31.9156;4.70178;22.6149;81.6409;69.1421;15.4235;33.4539;11.386;81.7848 8 14 8 360268;25106;29328;65210;25146;29184;50681;312382 SULT1E1_32446;RGN_9699;GPX4_32827;CYP2J4_32580;CYP17A1_32365;CD36_8243;ACOX1_7973;ABCG2_32656 39.701767499999995 47.025000000000006 22.939154312469928 29.545984999999998 34.9426 17.495237820539298 57.431312500000004 69.78565 30.2418391089203 50.1846;77.4407;45.9204;17.8395;49.6922;48.1296;23.1906;5.21654 36.5009;58.7732;34.2198;14.6501;35.6654;37.5433;16.2815;2.73368 80.9788;89.8047;70.4292;22.6149;81.6409;69.1421;33.4539;11.386 14 252922;85253;65164;24471;29540;24464;24384;294515;314322;83928;24890;24330;25373;25303 PZP_9633;PLG_9501;HTRA1_8856;HSPB1_8847;HSD17B7_8834;HP_8823;GC_32893;FOXO3_8662;FOS_8657;FETUB_33027;ESR1_33192;EGR1_8533;AHSG_8003;ABCC2_32541 33.14026507142866 32.8239 27.626050956544297 22.289642928571517 22.61195 18.45358687774116 56.37327142857152 47.61475 48.33889427826227 34.1871;70.7857;33.1323;89.1011;0.977494;64.9285;42.356;13.1992;1.28141E-12;32.5155;23.3972;0.750017;12.402;46.2316 26.3085;46.2356;25.6145;60.3265;0.322682;41.6103;26.3722;5.6804;1.28141E-12;19.6094;18.3088;0.186019;10.3013;31.1788 48.5666;150.579;46.6629;106.138;5.49472;136.455;78.7583;32.7581;1.28142E-12;49.9875;31.9156;4.70178;15.4235;81.7848 0 Exp 2,7(0.32);Exp 3,1(0.05);Exp 4,3(0.14);Hill,2(0.1);Linear,5(0.23);Poly 2,3(0.14);Power,1(0.05) 2.102746910823893 50.21379911899567 1.5074360370635986 5.973292827606201 1.1257146036338859 1.7995648384094238 24.804778489117574 46.247753419973456 17.388044430866728 32.468581114587934 39.26900334809039 74.24702392463699 DOWN 0.36363636363636365 0.6363636363636364 0.0 GO:0000038 7 very long-chain fatty acid metabolic process 10 12 6 6 4 6 4 4 158 8 2377 0.99946 0.0052174 0.0052174 33.33 65192;50681;192272;50559 slc27a2;acox1;acot2;acot1 SLC27A2_9860;ACOX1_7973;ACOT2_7969;ACOT1_7968 17.640835 15.869824999999999 7.62189 11.51433131197379 19.311031220190614 12.482921600355624 13.958855 11.739130000000001 5.49916 9.816227887348925 15.568802598273816 11.1201446575959 23.6327 23.423199999999998 10.4125 13.688427352572928 25.761103877776414 13.33705855519244 0.0 7.62189 0.5 8.085469999999999 7.62189;23.1906;8.54905;31.2018 5.49916;16.2815;7.19676;26.858 13.3925;33.4539;10.4125;37.2719 4 0 4 65192;50681;192272;50559 SLC27A2_9860;ACOX1_7973;ACOT2_7969;ACOT1_7968 17.640835 15.869824999999999 11.51433131197379 13.958855 11.739130000000001 9.816227887348925 23.6327 23.423199999999998 13.688427352572928 7.62189;23.1906;8.54905;31.2018 5.49916;16.2815;7.19676;26.858 13.3925;33.4539;10.4125;37.2719 0 0 Exp 2,1(0.25);Hill,1(0.25);Linear,1(0.25);Power,1(0.25) 15.184078734974864 364.1371250152588 2.18471097946167 344.14306640625 168.7858940437507 8.90467381477356 6.356790314265689 28.92487968573431 4.338951670398057 23.578758329601943 10.21804119447853 37.04735880552147 UP 1.0 0.0 0.0 GO:0007179 8 transforming growth factor beta receptor signaling pathway 27 29 4 4 3 4 3 3 159 26 2359 0.8916 0.27947 0.42657 10.34 25591;24516;314322 parp1;jun;fos PARP1_9425;JUN_8938;FOS_8657 14.468833333333762 16.4324 1.28141E-12 13.593829969633823 19.47059054251153 12.317245223142843 10.773800000000426 10.5224 1.28141E-12 10.90167426224001 15.019490345632429 10.32216821657062 25.06956666666709 35.2797 1.28142E-12 21.834980587655703 30.2504500291675 17.334103035195184 0.5 8.216200000000642 1.5 21.70325 26.9741;16.4324;1.28141E-12 21.799;10.5224;1.28141E-12 35.2797;39.929;1.28142E-12 1 2 1 25591 PARP1_9425 26.9741 26.9741 21.799 21.799 35.2797 35.2797 26.9741 21.799 35.2797 2 24516;314322 JUN_8938;FOS_8657 8.216200000000642 8.216200000000642 11.619461471168918 5.26120000000064 5.26120000000064 7.440460394356422 19.96450000000064 19.96450000000064 28.23406666599675 16.4324;1.28141E-12 10.5224;1.28141E-12 39.929;1.28142E-12 0 Exp 2,1(0.34);Hill,1(0.34);Poly 2,1(0.34) 1.8933430948245453 5.683843731880188 1.8086696863174438 1.9785058498382568 0.08493670361723765 1.8966681957244873 -0.9140333955469799 29.851700062214505 -1.5626057570464607 23.110205757047318 0.36096010340187945 49.77817322993231 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0030855 5 epithelial cell differentiation 87 96 8 8 5 7 4 4 158 92 2293 0.25702 0.8714 0.52086 4.17 81819;24516;497840;155423 pax8;jun;cps1;anxa7 PAX8_9432;JUN_8938;CPS1_32421;ANXA7_8051 52.487025 44.43785 16.4324 38.55607918658872 54.9839819495545 35.1159305117891 31.011899999999997 34.2045 10.5224 16.614532513034092 34.185205842457556 15.363472369080187 68.943975 63.57895 39.929 32.281946342847725 72.03360144066669 29.99828378176775 56.8931;16.4324;31.9826;104.64 45.1162;10.5224;24.4836;43.9254 81.5688;39.929;45.5891;108.689 2 2 2 81819;155423 PAX8_9432;ANXA7_8051 80.76655 80.76655 33.762156770636 44.5208 44.5208 0.8420227550368542 95.12889999999999 95.12889999999999 19.176877327135465 56.8931;104.64 45.1162;43.9254 81.5688;108.689 2 24516;497840 JUN_8938;CPS1_32421 24.207500000000003 24.207500000000003 10.995651868807041 17.503 17.503 9.872059193501626 42.75905 42.75905 4.002295092193944 16.4324;31.9826 10.5224;24.4836 39.929;45.5891 0 Exp 2,2(0.5);Exp 3,1(0.25);Poly 2,1(0.25) 1.768880097982028 7.10335636138916 1.5461770296096802 1.9785058498382568 0.17976041990339992 1.7893367409706116 14.702067397143061 90.27198260285695 14.729658137226597 47.2941418627734 37.307667584009224 100.58028241599077 CONFLICT 0.5 0.5 0.0 GO:0090100 7 positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway 30 31 2 2 2 2 2 2 160 29 2356 0.68484 0.59663 1.0 6.45 25591;29455 parp1;gdf15 PARP1_9425;GDF15_33113 66.06155 66.06155 26.9741 55.27800190858025 64.35452467769153 55.225262553499874 53.57384999999999 53.57384999999999 21.799 44.93642381237074 52.18618020924739 44.89355109755369 80.46585 80.46585 35.2797 63.90286616142502 78.49248253121837 63.84189803969888 0.5 66.06155 26.9741;105.149 21.799;85.3487 35.2797;125.652 1 1 1 25591 PARP1_9425 26.9741 26.9741 21.799 21.799 35.2797 35.2797 26.9741 21.799 35.2797 1 29455 GDF15_33113 105.149 105.149 85.3487 85.3487 125.652 125.652 105.149 85.3487 125.652 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.6800720564832266 3.3692874908447266 1.5606178045272827 1.8086696863174438 0.17539916769990682 1.6846437454223633 -10.549852000000001 142.672952 -8.704856 115.85255599999999 -8.099003999999994 169.03070399999996 CONFLICT 0.5 0.5 0.0 GO:0051239 4 regulation of multicellular organismal process 724 769 68 67 50 58 43 43 119 726 1659 0.16947 0.87228 0.33087 5.59 79426;24825;29573;24794;246074;25106;83516;29441;85253;25513;81819;25591;25493;24539;307582;288001;58954;24516;63868;24471;25675;113965;24957;29455;25112;289388;294515;314322;25661;361969;24890;29496;24330;116663;65210;25423;113936;25695;29184;79431;25373;25287;312382 zfp36;tf;slc37a4;serpina3c;scd;rgn;ppargc1a;por;plg;pik3r1;pax8;parp1;nfkbia;lpl;lama3;kng1;klf6;jun;hspd1;hspb1;hmgcr;hadh;glul;gdf15;gadd45a;g0s2;foxo3;fos;fn1;fga;esr1;erbb3;egr1;dusp6;cyp2j4;ctsc;cpb2;cebpd;cd36;bhlhe40;ahsg;acadl;abcg2 ZFP36_10204;TF_10003;SLC37A4_9871;SERPINA3C_32925;SCD1_9787;RGN_9699;PPARGC1A_33189;POR_9531;PLG_9501;PIK3R1_32562;PAX8_9432;PARP1_9425;NFKBIA_9307;LPL_32544;LAMA3_8980;KNG1L1_34113;KLF6_8969;JUN_8938;HSPD1_8849;HSPB1_8847;HMGCR_8810;HADH_8776;GLUL_32832;GDF15_33113;GADD45A_8678;G0S2_32729;FOXO3_8662;FOS_8657;FN1_8655;FGA_8632;ESR1_33192;ERBB3_8571;EGR1_8533;DUSP6_8506;CYP2J4_32580;CTSC_32456;CPB2_8369;CEBPD_8283;CD36_8243;BHLHE40_8141;AHSG_8003;ACADL_32776;ABCG2_32656 37.59147437209306 29.766 1.28141E-12 30.087340534274777 44.388228577224616 30.31460209383506 26.43816012093026 22.6911 1.28141E-12 22.163067808005323 31.37654201156907 23.15090184454366 67.9151251162791 45.5481 1.28142E-12 70.49267801278603 76.57982251215142 64.3142699917567 37.5 75.8224 0.348134;45.1539;39.7166;29.766;105.46;77.4407;42.4094;12.4414;70.7857;18.7324;56.8931;26.9741;0.520151;74.2041;2.46923;24.3655;18.9476;16.4324;42.2579;89.1011;1.63089;33.3125;26.4669;105.149;102.919;46.3784;13.1992;1.28141E-12;59.5777;28.5803;23.3972;60.9984;0.750017;62.3934;17.8395;56.2386;25.8316;0.306936;48.1296;57.8085;12.402;33.4878;5.21654 0.118102;28.132;22.6911;23.347;63.7532;58.7732;26.2988;8.48981;46.2356;11.6701;45.1162;21.799;0.160202;49.8682;0.871501;19.538;11.6941;10.5224;23.9469;60.3265;0.663137;25.7336;21.0456;85.3487;89.5012;33.7914;5.6804;1.28141E-12;31.0499;22.529;18.3088;41.6036;0.186019;39.0875;14.6501;38.2681;20.4374;0.0732342;37.5433;38.3491;10.3013;26.6039;2.73368 1.15962;61.5341;60.0334;40.8256;422.699;89.8047;81.7305;79.2355;150.579;41.5978;81.5688;35.2797;2.88499;155.425;10.4175;32.1467;45.5481;39.929;102.383;106.138;7.6286;46.9856;35.4303;125.652;115.437;73.6529;32.7581;1.28142E-12;105.243;38.8511;31.9156;113.972;4.70178;133.304;22.6149;102.888;34.8042;1.73689;69.1421;110.58;15.4235;45.3228;11.386 14 29 14 24825;246074;25106;81819;25591;24539;63868;113965;289388;29496;65210;29184;25287;312382 TF_10003;SCD1_9787;RGN_9699;PAX8_9432;PARP1_9425;LPL_32544;HSPD1_8849;HADH_8776;G0S2_32729;ERBB3_8571;CYP2J4_32580;CD36_8243;ACADL_32776;ABCG2_32656 48.124752857142866 45.766149999999996 25.951289702168612 33.860591428571425 30.9617 16.87937946044357 95.12647142857143 71.39750000000001 101.70634422203675 45.1539;105.46;77.4407;56.8931;26.9741;74.2041;42.2579;33.3125;46.3784;60.9984;17.8395;48.1296;33.4878;5.21654 28.132;63.7532;58.7732;45.1162;21.799;49.8682;23.9469;25.7336;33.7914;41.6036;14.6501;37.5433;26.6039;2.73368 61.5341;422.699;89.8047;81.5688;35.2797;155.425;102.383;46.9856;73.6529;113.972;22.6149;69.1421;45.3228;11.386 29 79426;29573;24794;83516;29441;85253;25513;25493;307582;288001;58954;24516;24471;25675;24957;29455;25112;294515;314322;25661;361969;24890;24330;116663;25423;113936;25695;79431;25373 ZFP36_10204;SLC37A4_9871;SERPINA3C_32925;PPARGC1A_33189;POR_9531;PLG_9501;PIK3R1_32562;NFKBIA_9307;LAMA3_8980;KNG1L1_34113;KLF6_8969;JUN_8938;HSPB1_8847;HMGCR_8810;GLUL_32832;GDF15_33113;GADD45A_8678;FOXO3_8662;FOS_8657;FN1_8655;FGA_8632;ESR1_33192;EGR1_8533;DUSP6_8506;CTSC_32456;CPB2_8369;CEBPD_8283;BHLHE40_8141;AHSG_8003 32.50644337931039 24.3655 31.031175458521368 22.8549174206897 19.538 23.74187623675553 54.77861310344832 39.929 45.849879999233 0.348134;39.7166;29.766;42.4094;12.4414;70.7857;18.7324;0.520151;2.46923;24.3655;18.9476;16.4324;89.1011;1.63089;26.4669;105.149;102.919;13.1992;1.28141E-12;59.5777;28.5803;23.3972;0.750017;62.3934;56.2386;25.8316;0.306936;57.8085;12.402 0.118102;22.6911;23.347;26.2988;8.48981;46.2356;11.6701;0.160202;0.871501;19.538;11.6941;10.5224;60.3265;0.663137;21.0456;85.3487;89.5012;5.6804;1.28141E-12;31.0499;22.529;18.3088;0.186019;39.0875;38.2681;20.4374;0.0732342;38.3491;10.3013 1.15962;60.0334;40.8256;81.7305;79.2355;150.579;41.5978;2.88499;10.4175;32.1467;45.5481;39.929;106.138;7.6286;35.4303;125.652;115.437;32.7581;1.28142E-12;105.243;38.8511;31.9156;4.70178;133.304;102.888;34.8042;1.73689;110.58;15.4235 0 Exp 2,13(0.31);Exp 3,1(0.03);Exp 4,5(0.12);Hill,4(0.1);Linear,9(0.21);Poly 2,10(0.24);Power,1(0.03) 1.9219679925178326 85.3079241514206 1.5074360370635986 4.21828556060791 0.5862870904504747 1.8086696863174438 28.598452595582273 46.58449614860382 19.813681257315704 33.06263898454482 46.84506118918077 88.98518904337746 DOWN 0.32558139534883723 0.6744186046511628 0.0 GO:0071294 7 cellular response to zinc ion 4 7 2 2 2 2 2 2 160 5 2380 0.99269 0.068343 0.068343 28.57 25591;24567 parp1;mt1 PARP1_9425;MT1A_9255 19.9528 19.9528 12.9315 9.92961768549021 23.98908205337136 8.124909953424986 15.354665 15.354665 8.91033 9.113665957475613 19.05927151252801 7.457257428781711 29.37165 29.37165 23.4636 8.355244437178364 32.76796637808108 6.836678998238542 0.0 12.9315 0.0 12.9315 26.9741;12.9315 21.799;8.91033 35.2797;23.4636 1 1 1 25591 PARP1_9425 26.9741 26.9741 21.799 21.799 35.2797 35.2797 26.9741 21.799 35.2797 1 24567 MT1A_9255 12.9315 12.9315 8.91033 8.91033 23.4636 23.4636 12.9315 8.91033 23.4636 0 Exp 2,1(0.5);Poly 2,1(0.5) 2.0277574966905094 4.082053542137146 1.8086696863174438 2.273383855819702 0.3286025405685215 2.041026771068573 6.191052000000001 33.714548 2.723768400000001 27.9855616 17.791872 40.95142799999999 CONFLICT 0.5 0.5 0.0 GO:0034599 5 cellular response to oxidative stress 95 101 10 10 10 10 10 10 152 91 2294 0.94724 0.10471 0.14279 9.9 83516;25591;24314;58954;24516;24471;294515;314322;24360;29184 ppargc1a;parp1;nqo1;klf6;jun;hspb1;foxo3;fos;fabp1;cd36 PPARGC1A_33189;PARP1_9425;NQO1_33055;KLF6_8969;JUN_8938;HSPB1_8847;FOXO3_8662;FOS_8657;FABP1_33091;CD36_8243 37.63177000000013 30.41095 1.28141E-12 30.159276767892205 40.87148159030693 26.6059021337725 26.103730000000134 24.0489 1.28141E-12 21.256492495185586 29.114699046927154 18.38070304784161 65.45682000000014 46.2369 1.28142E-12 54.69477390567466 61.90550177579288 36.38708491452175 4.5 30.41095 42.4094;26.9741;87.2765;18.9476;16.4324;89.1011;13.1992;1.28141E-12;33.8478;48.1296 26.2988;21.799;60.6992;11.6941;10.5224;60.3265;5.6804;1.28141E-12;26.4736;37.5433 81.7305;35.2797;197.117;45.5481;39.929;106.138;32.7581;1.28142E-12;46.9257;69.1421 4 6 4 25591;24314;24360;29184 PARP1_9425;NQO1_33055;FABP1_33091;CD36_8243 49.057 40.9887 26.960245350391993 36.628775 32.00845 17.3519597499101 87.116125 58.0339 74.6671353272364 26.9741;87.2765;33.8478;48.1296 21.799;60.6992;26.4736;37.5433 35.2797;197.117;46.9257;69.1421 6 83516;58954;24516;24471;294515;314322 PPARGC1A_33189;KLF6_8969;JUN_8938;HSPB1_8847;FOXO3_8662;FOS_8657 30.014950000000212 17.69 32.04819522130669 19.087033333333547 11.10825 22.021645059410456 51.017283333333545 42.738550000000004 37.6048349343225 42.4094;18.9476;16.4324;89.1011;13.1992;1.28141E-12 26.2988;11.6941;10.5224;60.3265;5.6804;1.28141E-12 81.7305;45.5481;39.929;106.138;32.7581;1.28142E-12 0 Exp 2,5(0.5);Exp 4,1(0.1);Hill,1(0.1);Poly 2,3(0.3) 1.861780293041395 18.82355272769928 1.5740432739257812 2.6703107357025146 0.3136337658851554 1.8420060873031616 18.938856594691742 56.324683405308505 12.928819455191933 39.27864054480832 31.556647916624556 99.35699208337572 DOWN 0.4 0.6 0.0 GO:0045934 7 negative regulation of nucleobase-containing compound metabolic process 253 266 22 22 17 20 16 16 146 250 2135 0.46789 0.63672 0.89485 6.02 79426;24522;246273;25106;83516;25591;24516;25112;294515;24890;24330;140942;25695;114851;29184;79431 zfp36;zfp354a;trib3;rgn;ppargc1a;parp1;jun;gadd45a;foxo3;esr1;egr1;ddit4;cebpd;cdkn1a;cd36;bhlhe40 ZFP36_10204;ZFP354A_10203;TRIB3_10079;RGN_9699;PPARGC1A_33189;PARP1_9425;JUN_8938;GADD45A_8678;FOXO3_8662;ESR1_33192;EGR1_8533;DDIT4_8450;CEBPD_8283;CDKN1A_8271;CD36_8243;BHLHE40_8141 38.3003615 25.185650000000003 0.306936 38.01472705759199 36.71560235378064 38.70680278695932 27.93710345 20.0539 0.0732342 29.866173121418136 28.07735676473464 31.876118764392547 64.072135 37.60435 1.15962 66.11231387745562 54.447709741986756 54.40609421266533 12.5 82.4914 0.348134;0.834827;108.064;77.4407;42.4094;26.9741;16.4324;102.919;13.1992;23.3972;0.750017;87.5421;0.306936;6.24967;48.1296;57.8085 0.118102;0.27095;83.8836;58.7732;26.2988;21.799;10.5224;89.5012;5.6804;18.3088;0.186019;53.2453;0.0732342;2.44025;37.5433;38.3491 1.15962;2.99857;143.428;89.8047;81.7305;35.2797;39.929;115.437;32.7581;31.9156;4.70178;245.492;1.73689;19.0606;69.1421;110.58 3 13 3 25106;25591;29184 RGN_9699;PARP1_9425;CD36_8243 50.84813333333333 48.1296 25.342893412223756 39.371833333333335 37.5433 18.554797682091113 64.74216666666666 69.1421 27.52750381442774 77.4407;26.9741;48.1296 58.7732;21.799;37.5433 89.8047;35.2797;69.1421 13 79426;24522;246273;83516;24516;25112;294515;24890;24330;140942;25695;114851;79431 ZFP36_10204;ZFP354A_10203;TRIB3_10079;PPARGC1A_33189;JUN_8938;GADD45A_8678;FOXO3_8662;ESR1_33192;EGR1_8533;DDIT4_8450;CEBPD_8283;CDKN1A_8271;BHLHE40_8141 35.40472184615385 16.4324 40.631398362733144 25.298319630769228 10.5224 31.896294111589835 63.917512307692306 32.7581 73.05556454242998 0.348134;0.834827;108.064;42.4094;16.4324;102.919;13.1992;23.3972;0.750017;87.5421;0.306936;6.24967;57.8085 0.118102;0.27095;83.8836;26.2988;10.5224;89.5012;5.6804;18.3088;0.186019;53.2453;0.0732342;2.44025;38.3491 1.15962;2.99857;143.428;81.7305;39.929;115.437;32.7581;31.9156;4.70178;245.492;1.73689;19.0606;110.58 0 Exp 2,5(0.32);Exp 4,2(0.13);Hill,4(0.25);Linear,1(0.07);Poly 2,4(0.25) 2.069746946483341 35.14028704166412 1.522104263305664 4.591650485992432 0.9148480837152254 1.842902958393097 19.673145241779917 56.92757775822007 13.302678620505114 42.571528279494885 31.677101200046742 96.46716879995327 DOWN 0.1875 0.8125 0.0 GO:0071385 8 cellular response to glucocorticoid stimulus 47 51 16 16 11 14 9 9 153 42 2343 0.99892 0.0040892 0.0040892 17.65 79426;286954;294515;25315;116636;140942;25698;312382;25303 zfp36;ugt2b1;foxo3;ephx1;eif4ebp1;ddit4;ass1;abcg2;abcc2 ZFP36_10204;UGT2B10_33303,UGT2B1_33224;FOXO3_8662;EPHX1_8567;EIF4EBP1_8550;DDIT4_8450;ASS1_33159;ABCG2_32656;ABCC2_32541 35.90994711111111 26.8037 0.348134 32.71816290963415 34.52659926534999 30.343100110462277 22.021198000000002 20.9825 0.118102 19.314049436430228 21.405126248292632 17.535119128687768 68.52970777777779 36.7081 1.15962 75.13874917560707 57.46515566052485 55.4834508584781 1.5 8.84562 4.5 36.51765 0.348134;47.47345;13.1992;12.4747;83.9001;87.5421;26.8037;5.21654;46.2316 0.118102;34.82915;5.6804;7.00435;42.4185;53.2453;20.9825;2.73368;31.1788 1.15962;76.47475;32.7581;23.684;107.32;245.492;36.7081;11.386;81.7848 5 5 4 286954;25315;116636;312382 UGT2B10_33303,UGT2B1_33224;EPHX1_8567;EIF4EBP1_8550;ABCG2_32656 37.266197500000004 29.974075 36.1511076830668 21.74642 20.91675 19.80997750269461 54.7161875 50.079375 45.02257930350754 47.47345;12.4747;83.9001;5.21654 34.82915;7.00435;42.4185;2.73368 76.47475;23.684;107.32;11.386 5 79426;294515;140942;25698;25303 ZFP36_10204;FOXO3_8662;DDIT4_8450;ASS1_33159;ABCC2_32541 34.8249468 26.8037 34.02158845669837 22.2410204 20.9825 21.250945848692968 79.580524 36.7081 97.09750127350281 0.348134;13.1992;87.5421;26.8037;46.2316 0.118102;5.6804;53.2453;20.9825;31.1788 1.15962;32.7581;245.492;36.7081;81.7848 0 Exp 2,4(0.4);Exp 3,1(0.1);Exp 4,2(0.2);Hill,2(0.2);Linear,1(0.1) 1.8221115772505352 18.374735593795776 1.5074360370635986 2.4453113079071045 0.260798252193112 1.815986156463623 14.534080676816796 57.28581354540542 9.402685701532247 34.63971029846775 19.439058316381143 117.62035723917441 CONFLICT 0.4444444444444444 0.5555555555555556 0.0 GO:0110111 6 negative regulation of animal organ morphogenesis 10 12 2 2 2 2 2 2 160 10 2375 0.96369 0.17482 0.17482 16.67 81819;113936 pax8;cpb2 PAX8_9432;CPB2_8369 41.36235 41.36235 25.8316 21.963797283825954 52.84988264777413 14.781122367995211 32.7768 32.7768 20.4374 17.45054683154656 41.90380676747383 11.743810269796326 58.186499999999995 58.186499999999995 34.8042 33.06756577947644 75.48153949455428 22.253699115958593 0.0 25.8316 0.5 41.36235 56.8931;25.8316 45.1162;20.4374 81.5688;34.8042 1 1 1 81819 PAX8_9432 56.8931 56.8931 45.1162 45.1162 81.5688 81.5688 56.8931 45.1162 81.5688 1 113936 CPB2_8369 25.8316 25.8316 20.4374 20.4374 34.8042 34.8042 25.8316 20.4374 34.8042 0 Exp 2,2(1) 1.6549427045127845 3.3152835369110107 1.5630855560302734 1.7521979808807373 0.13372267801839435 1.6576417684555054 10.922080000000008 71.80261999999999 8.591576000000007 56.962024 12.357191999999998 104.01580799999999 CONFLICT 0.5 0.5 0.0 GO:0045321 3 leukocyte activation 139 149 7 6 4 5 4 4 158 145 2240 0.03257 0.98887 0.056977 2.68 25513;24516;63868;24330 pik3r1;jun;hspd1;egr1 PIK3R1_32562;JUN_8938;HSPD1_8849;EGR1_8533 19.54317925 17.5824 0.750017 17.12187486462631 19.876766179915883 19.38387667419801 11.58135475 11.09625 0.186019 9.727789181291755 11.587117914377693 11.043303884668578 47.152895 40.763400000000004 4.70178 40.5606763688029 48.48734937743392 45.81971953102008 18.7324;16.4324;42.2579;0.750017 11.6701;10.5224;23.9469;0.186019 41.5978;39.929;102.383;4.70178 1 3 1 63868 HSPD1_8849 42.2579 42.2579 23.9469 23.9469 102.383 102.383 42.2579 23.9469 102.383 3 25513;24516;24330 PIK3R1_32562;JUN_8938;EGR1_8533 11.971605666666667 16.4324 9.785986876799717 7.459506333333333 10.5224 6.3251100633601895 28.742859999999997 39.929 20.83689921832901 18.7324;16.4324;0.750017 11.6701;10.5224;0.186019 41.5978;39.929;4.70178 0 Exp 3,1(0.25);Hill,1(0.25);Poly 2,2(0.5) 2.3681807413329525 10.122222065925598 1.6735800504684448 4.21828556060791 1.1496774784425312 2.1151782274246216 2.763741882666217 36.322616617333786 2.04812135233408 21.11458814766592 7.40343215857316 86.90235784142683 DOWN 0.25 0.75 0.0 GO:0003331 7 positive regulation of extracellular matrix constituent secretion 1 1 1 1 1 1 1 1 161 0 2385 1.0 0.063604 0.063604 100.0 113936 cpb2 CPB2_8369 25.8316 25.8316 25.8316 25.8316 20.4374 20.4374 20.4374 20.4374 34.8042 34.8042 34.8042 34.8042 0.0 25.8316 0.0 25.8316 25.8316 20.4374 34.8042 0 1 0 1 113936 CPB2_8369 25.8316 25.8316 20.4374 20.4374 34.8042 34.8042 25.8316 20.4374 34.8042 0 Exp 2,1(1) 1.5630855560302734 1.5630855560302734 1.5630855560302734 1.5630855560302734 0.0 1.5630855560302734 25.8316 25.8316 20.4374 20.4374 34.8042 34.8042 DOWN 0.0 1.0 0.0 GO:0014070 5 response to organic cyclic compound 433 471 70 70 54 65 50 50 112 421 1964 0.99997 5.7346E-5 9.0313E-5 10.62 79426;24522;312688;286954;24825;170698;29573;24648;83516;298199;24651;25513;25591;24314;25493;58954;24516;81678;63868;29540;24464;25675;81869;29328;24384;294515;314322;25661;246186;361969;24890;25315;116636;24330;116663;140942;25428;65210;25146;497840;81718;114851;29184;25698;65054;155423;24158;312382;140668;25303 zfp36;zfp354a;usp18;ugt2b1;tf;slco1a2;slc37a4;serpina1;ppargc1a;plin2;pklr;pik3r1;parp1;nqo1;nfkbia;klf6;jun;itpr2;hspd1;hsd17b7;hp;hmgcr;gstm7;gpx4;gc;foxo3;fos;fn1;fgl1;fga;esr1;ephx1;eif4ebp1;egr1;dusp6;ddit4;cyp7a1;cyp2j4;cyp17a1;cps1;cdo1;cdkn1a;cd36;ass1;aqp9;anxa7;acadm;abcg2;abcc3;abcc2 ZFP36_10204;ZFP354A_10203;USP18_10138;UGT2B10_33303,UGT2B1_33224;TF_10003;SLCO1A2_9886;SLC37A4_9871;SERPINA1_9807;PPARGC1A_33189;PLIN2_9502;PKLR_9489;PIK3R1_32562;PARP1_9425;NQO1_33055;NFKBIA_9307;KLF6_8969;JUN_8938;ITPR2_8931;HSPD1_8849;HSD17B7_8834;HP_8823;HMGCR_8810;GSTM7_8761;GPX4_32827;GC_32893;FOXO3_8662;FOS_8657;FN1_8655;FGL1_8640;FGA_8632;ESR1_33192;EPHX1_8567;EIF4EBP1_8550;EGR1_8533;DUSP6_8506;DDIT4_8450;CYP7A1_8430;CYP2J4_32580;CYP17A1_32365;CPS1_32421;CDO1_8275;CDKN1A_8271;CD36_8243;ASS1_33159;AQP9_32709;ANXA7_8051;ACADM_7957;ABCG2_32656;ABCC3_7941;ABCC2_32541 34.49131306000003 27.35285 1.28141E-12 29.046950665309083 34.06234772825352 25.562459934853536 22.82071410000003 21.8681 1.28141E-12 18.654685947725717 22.195059589913516 15.411453676033785 57.93703860000003 40.763400000000004 1.28142E-12 51.093322852638586 55.76386019858428 42.114310537855125 22.5 26.2277 46.5 95.86955 0.348134;0.834827;108.883;47.47345;45.1539;104.197;39.7166;15.797;42.4094;25.6517;23.0963;18.7324;26.9741;87.2765;0.520151;18.9476;16.4324;31.8111;42.2579;0.977494;64.9285;1.63089;42.3152;45.9204;42.356;13.1992;1.28141E-12;59.5777;15.4757;28.5803;23.3972;12.4747;83.9001;0.750017;62.3934;87.5421;5.72128;17.8395;49.6922;31.9826;22.9638;6.24967;48.1296;26.8037;27.7316;104.64;11.7137;5.21654;37.7175;46.2316 0.118102;0.27095;73.1414;34.82915;28.132;80.3101;22.6911;13.013;26.2988;20.9252;17.4625;11.6701;21.799;60.6992;0.160202;11.6941;10.5224;24.7342;23.9469;0.322682;41.6103;0.663137;31.4035;34.2198;26.3722;5.6804;1.28141E-12;31.0499;10.2138;22.529;18.3088;7.00435;42.4185;0.186019;39.0875;53.2453;0.985273;14.6501;35.6654;24.4836;18.5144;2.44025;37.5433;20.9825;21.9372;43.9254;8.36151;2.73368;30.9007;31.1788 1.15962;2.99857;138.144;76.47475;61.5341;128.412;60.0334;19.9134;81.7305;33.0375;32.9443;41.5978;35.2797;197.117;2.88499;45.5481;39.929;44.3296;102.383;5.49472;136.455;7.6286;64.5991;70.4292;78.7583;32.7581;1.28142E-12;105.243;30.4106;38.8511;31.9156;23.684;107.32;4.70178;133.304;245.492;22.3625;22.6149;81.6409;45.5891;30.0179;19.0606;69.1421;36.7081;37.4625;108.689;18.9642;11.386;48.9329;81.7848 19 32 18 312688;286954;24825;298199;25591;24314;63868;81869;29328;25315;116636;65210;25146;29184;155423;24158;312382;140668 USP18_10138;UGT2B10_33303,UGT2B1_33224;TF_10003;PLIN2_9502;PARP1_9425;NQO1_33055;HSPD1_8849;GSTM7_8761;GPX4_32827;EPHX1_8567;EIF4EBP1_8550;CYP2J4_32580;CYP17A1_32365;CD36_8243;ANXA7_8051;ACADM_7957;ABCG2_32656;ABCC3_7941 46.846110555555555 43.73455 30.84046464347668 30.683282777777777 31.1521 17.891985844124807 70.63179722222222 66.8706 47.56354716482087 108.883;47.47345;45.1539;25.6517;26.9741;87.2765;42.2579;42.3152;45.9204;12.4747;83.9001;17.8395;49.6922;48.1296;104.64;11.7137;5.21654;37.7175 73.1414;34.82915;28.132;20.9252;21.799;60.6992;23.9469;31.4035;34.2198;7.00435;42.4185;14.6501;35.6654;37.5433;43.9254;8.36151;2.73368;30.9007 138.144;76.47475;61.5341;33.0375;35.2797;197.117;102.383;64.5991;70.4292;23.684;107.32;22.6149;81.6409;69.1421;108.689;18.9642;11.386;48.9329 32 79426;24522;170698;29573;24648;83516;24651;25513;25493;58954;24516;81678;29540;24464;25675;24384;294515;314322;25661;246186;361969;24890;24330;116663;140942;25428;497840;81718;114851;25698;65054;25303 ZFP36_10204;ZFP354A_10203;SLCO1A2_9886;SLC37A4_9871;SERPINA1_9807;PPARGC1A_33189;PKLR_9489;PIK3R1_32562;NFKBIA_9307;KLF6_8969;JUN_8938;ITPR2_8931;HSD17B7_8834;HP_8823;HMGCR_8810;GC_32893;FOXO3_8662;FOS_8657;FN1_8655;FGL1_8640;FGA_8632;ESR1_33192;EGR1_8533;DUSP6_8506;DDIT4_8450;CYP7A1_8430;CPS1_32421;CDO1_8275;CDKN1A_8271;ASS1_33159;AQP9_32709;ABCC2_32541 27.54173946875004 23.03005 25.952954132579034 18.39801921875004 17.88565 17.844387654587578 50.79623687500004 37.085300000000004 52.34019282428104 0.348134;0.834827;104.197;39.7166;15.797;42.4094;23.0963;18.7324;0.520151;18.9476;16.4324;31.8111;0.977494;64.9285;1.63089;42.356;13.1992;1.28141E-12;59.5777;15.4757;28.5803;23.3972;0.750017;62.3934;87.5421;5.72128;31.9826;22.9638;6.24967;26.8037;27.7316;46.2316 0.118102;0.27095;80.3101;22.6911;13.013;26.2988;17.4625;11.6701;0.160202;11.6941;10.5224;24.7342;0.322682;41.6103;0.663137;26.3722;5.6804;1.28141E-12;31.0499;10.2138;22.529;18.3088;0.186019;39.0875;53.2453;0.985273;24.4836;18.5144;2.44025;20.9825;21.9372;31.1788 1.15962;2.99857;128.412;60.0334;19.9134;81.7305;32.9443;41.5978;2.88499;45.5481;39.929;44.3296;5.49472;136.455;7.6286;78.7583;32.7581;1.28142E-12;105.243;30.4106;38.8511;31.9156;4.70178;133.304;245.492;22.3625;45.5891;30.0179;19.0606;36.7081;37.4625;81.7848 0 Exp 2,17(0.34);Exp 3,4(0.08);Exp 4,6(0.12);Hill,6(0.12);Linear,8(0.16);Poly 2,8(0.16);Power,2(0.04) 1.9538253787053455 104.28125667572021 1.5074360370635986 4.591650485992432 0.74294337661947 1.8086696863174438 26.439909111013414 42.542717008986635 17.649898965659453 27.991529234340582 43.77469205551793 72.09938514448213 DOWN 0.36 0.64 0.0 GO:0019222 4 regulation of metabolic process 1092 1179 106 106 86 94 77 77 85 1102 1283 0.65914 0.40225 0.74546 6.53 79426;24522;308843;246273;25357;24825;170698;29573;293615;79224;24794;24648;246074;25106;252922;192280;83516;29441;303612;363465;25513;81819;25591;81525;25493;24552;24539;299282;288001;58954;24516;54404;50693;306251;494344;63868;24471;24464;25675;113965;290556;29455;299626;25112;289388;294515;314322;25661;246186;361969;83928;24360;308441;24890;29496;65030;116636;24330;116663;140942;25428;65210;25146;25423;113936;25695;114851;29184;246142;79431;25698;155423;25377;25373;24158;25287;25303 zfp36;zfp354a;tsku;trib3;thrsp;tf;slco1a2;slc37a4;sirt3;serpind1;serpina3c;serpina1;scd;rgn;pzp;ppp1r3b;ppargc1a;por;polg2;pir;pik3r1;pax8;parp1;nfkbib;nfkbia;me1;lpl;loc299282;kng1;klf6;jun;itih4;itih3;itih1;ier2;hspd1;hspb1;hp;hmgcr;hadh;gnl3;gdf15;gadd45b;gadd45a;g0s2;foxo3;fos;fn1;fgl1;fga;fetub;fabp1;exosc5;esr1;erbb3;ephx2;eif4ebp1;egr1;dusp6;ddit4;cyp7a1;cyp2j4;cyp17a1;ctsc;cpb2;cebpd;cdkn1a;cd36;bmf;bhlhe40;ass1;anxa7;ambp;ahsg;acadm;acadl;abcc2 ZFP36_10204;ZFP354A_10203;TSKU_10094;TRIB3_10079;THRSP_33314;TF_10003;SLCO1A2_9886;SLC37A4_9871;SIRT3_9828;SERPIND1_9812;SERPINA3C_32925;SERPINA1_9807;SCD1_9787;RGN_9699;PZP_9633;PPP1R3B_9545;PPARGC1A_33189;POR_9531;POLG2_9521;PIR_9487;PIK3R1_32562;PAX8_9432;PARP1_9425;NFKBIB_9308;NFKBIA_9307;ME1_9215;LPL_32544;LOC299282_9119;KNG1L1_34113;KLF6_8969;JUN_8938;ITIH4_32725;ITIH3_32422;ITIH1_33132;IER2_32643;HSPD1_8849;HSPB1_8847;HP_8823;HMGCR_8810;HADH_8776;GNL3_8735;GDF15_33113;GADD45B_8679;GADD45A_8678;G0S2_32729;FOXO3_8662;FOS_8657;FN1_8655;FGL1_8640;FGA_8632;FETUB_33027;FABP1_33091;EXOSC5_32543;ESR1_33192;ERBB3_8571;EPHX2_33282;EIF4EBP1_8550;EGR1_8533;DUSP6_8506;DDIT4_8450;CYP7A1_8430;CYP2J4_32580;CYP17A1_32365;CTSC_32456;CPB2_8369;CEBPD_8283;CDKN1A_8271;CD36_8243;BMF_8152;BHLHE40_8141;ASS1_33159;ANXA7_8051;AMBP_33085;AHSG_8003;ACADM_7957;ACADL_32776;ABCC2_32541 43.29143824675326 36.1411 1.28141E-12 31.91459998084151 45.72668252054952 30.647703943324714 29.469279807792226 26.3085 1.28141E-12 21.790281368515817 31.24668536728174 21.581650153394484 72.00341220779221 57.2113 1.28142E-12 64.15999633091128 73.29991769185175 55.779642452665264 57.5 61.695899999999995 0.348134;0.834827;1.38416;108.064;32.2053;45.1539;104.197;39.7166;2.38018;28.261;29.766;15.797;105.46;77.4407;34.1871;36.1411;42.4094;12.4414;63.7758;50.0307;18.7324;56.8931;26.9741;30.5572;0.520151;80.7944;74.2041;45.2017;24.3655;18.9476;16.4324;57.1163;27.1247;98.1741;49.6814;42.2579;89.1011;64.9285;1.63089;33.3125;87.6357;105.149;106.367;102.919;46.3784;13.1992;1.28141E-12;59.5777;15.4757;28.5803;32.5155;33.8478;41.9329;23.3972;60.9984;38.7293;83.9001;0.750017;62.3934;87.5421;5.72128;17.8395;49.6922;56.2386;25.8316;0.306936;6.24967;48.1296;94.8767;57.8085;26.8037;104.64;17.2343;12.402;11.7137;33.4878;46.2316 0.118102;0.27095;0.540568;83.8836;24.3966;28.132;80.3101;22.6911;0.56209;22.307;23.347;13.013;63.7532;58.7732;26.3085;27.0588;26.2988;8.48981;40.9553;38.7717;11.6701;45.1162;21.799;24.2439;0.160202;59.856;49.8682;30.7472;19.538;11.6941;10.5224;39.6402;21.5108;42.9071;33.4626;23.9469;60.3265;41.6103;0.663137;25.7336;54.41;85.3487;52.7132;89.5012;33.7914;5.6804;1.28141E-12;31.0499;10.2138;22.529;19.6094;26.4736;31.7336;18.3088;41.6036;29.2097;42.4185;0.186019;39.0875;53.2453;0.985273;14.6501;35.6654;38.2681;20.4374;0.0732342;2.44025;37.5433;73.1342;38.3491;20.9825;43.9254;14.1233;10.3013;8.36151;26.6039;31.1788 1.15962;2.99857;4.10872;143.428;46.6068;61.5341;128.412;60.0334;8.82917;38.3264;40.8256;19.9134;422.699;89.8047;48.5666;53.6244;81.7305;79.2355;132.567;73.0083;41.5978;81.5688;35.2797;41.2611;2.88499;94.0621;155.425;78.6415;32.1467;45.5481;39.929;101.869;36.4819;104.278;89.4404;102.383;106.138;136.455;7.6286;46.9856;238.963;125.652;109.434;115.437;73.6529;32.7581;1.28142E-12;105.243;30.4106;38.8511;49.9875;46.9257;62.1373;31.9156;113.972;57.2113;107.32;4.70178;133.304;245.492;22.3625;22.6149;81.6409;102.888;34.8042;1.73689;19.0606;69.1421;109.848;110.58;36.7081;108.689;21.9073;15.4235;18.9642;45.3228;81.7848 26 51 26 24825;293615;246074;25106;363465;81819;25591;81525;24539;63868;113965;290556;299626;289388;24360;308441;29496;65030;116636;65210;25146;29184;246142;155423;24158;25287 TF_10003;SIRT3_9828;SCD1_9787;RGN_9699;PIR_9487;PAX8_9432;PARP1_9425;NFKBIB_9308;LPL_32544;HSPD1_8849;HADH_8776;GNL3_8735;GADD45B_8679;G0S2_32729;FABP1_33091;EXOSC5_32543;ERBB3_8571;EPHX2_33282;EIF4EBP1_8550;CYP2J4_32580;CYP17A1_32365;CD36_8243;BMF_8152;ANXA7_8051;ACADM_7957;ACADL_32776 54.03205692307692 47.254000000000005 29.450322424705753 35.88220769230769 34.7284 16.832060483787078 91.71602192307692 73.3306 82.528079421762 45.1539;2.38018;105.46;77.4407;50.0307;56.8931;26.9741;30.5572;74.2041;42.2579;33.3125;87.6357;106.367;46.3784;33.8478;41.9329;60.9984;38.7293;83.9001;17.8395;49.6922;48.1296;94.8767;104.64;11.7137;33.4878 28.132;0.56209;63.7532;58.7732;38.7717;45.1162;21.799;24.2439;49.8682;23.9469;25.7336;54.41;52.7132;33.7914;26.4736;31.7336;41.6036;29.2097;42.4185;14.6501;35.6654;37.5433;73.1342;43.9254;8.36151;26.6039 61.5341;8.82917;422.699;89.8047;73.0083;81.5688;35.2797;41.2611;155.425;102.383;46.9856;238.963;109.434;73.6529;46.9257;62.1373;113.972;57.2113;107.32;22.6149;81.6409;69.1421;109.848;108.689;18.9642;45.3228 51 79426;24522;308843;246273;25357;170698;29573;79224;24794;24648;252922;192280;83516;29441;303612;25513;25493;24552;299282;288001;58954;24516;54404;50693;306251;494344;24471;24464;25675;29455;25112;294515;314322;25661;246186;361969;83928;24890;24330;116663;140942;25428;25423;113936;25695;114851;79431;25698;25377;25373;25303 ZFP36_10204;ZFP354A_10203;TSKU_10094;TRIB3_10079;THRSP_33314;SLCO1A2_9886;SLC37A4_9871;SERPIND1_9812;SERPINA3C_32925;SERPINA1_9807;PZP_9633;PPP1R3B_9545;PPARGC1A_33189;POR_9531;POLG2_9521;PIK3R1_32562;NFKBIA_9307;ME1_9215;LOC299282_9119;KNG1L1_34113;KLF6_8969;JUN_8938;ITIH4_32725;ITIH3_32422;ITIH1_33132;IER2_32643;HSPB1_8847;HP_8823;HMGCR_8810;GDF15_33113;GADD45A_8678;FOXO3_8662;FOS_8657;FN1_8655;FGL1_8640;FGA_8632;FETUB_33027;ESR1_33192;EGR1_8533;DUSP6_8506;DDIT4_8450;CYP7A1_8430;CTSC_32456;CPB2_8369;CEBPD_8283;CDKN1A_8271;BHLHE40_8141;ASS1_33159;AMBP_33085;AHSG_8003;ABCC2_32541 37.81582872549022 28.5803 31.999265899342717 26.19994402352944 22.307 23.404573866006945 61.95384647058825 45.5481 50.463521204621884 0.348134;0.834827;1.38416;108.064;32.2053;104.197;39.7166;28.261;29.766;15.797;34.1871;36.1411;42.4094;12.4414;63.7758;18.7324;0.520151;80.7944;45.2017;24.3655;18.9476;16.4324;57.1163;27.1247;98.1741;49.6814;89.1011;64.9285;1.63089;105.149;102.919;13.1992;1.28141E-12;59.5777;15.4757;28.5803;32.5155;23.3972;0.750017;62.3934;87.5421;5.72128;56.2386;25.8316;0.306936;6.24967;57.8085;26.8037;17.2343;12.402;46.2316 0.118102;0.27095;0.540568;83.8836;24.3966;80.3101;22.6911;22.307;23.347;13.013;26.3085;27.0588;26.2988;8.48981;40.9553;11.6701;0.160202;59.856;30.7472;19.538;11.6941;10.5224;39.6402;21.5108;42.9071;33.4626;60.3265;41.6103;0.663137;85.3487;89.5012;5.6804;1.28141E-12;31.0499;10.2138;22.529;19.6094;18.3088;0.186019;39.0875;53.2453;0.985273;38.2681;20.4374;0.0732342;2.44025;38.3491;20.9825;14.1233;10.3013;31.1788 1.15962;2.99857;4.10872;143.428;46.6068;128.412;60.0334;38.3264;40.8256;19.9134;48.5666;53.6244;81.7305;79.2355;132.567;41.5978;2.88499;94.0621;78.6415;32.1467;45.5481;39.929;101.869;36.4819;104.278;89.4404;106.138;136.455;7.6286;125.652;115.437;32.7581;1.28142E-12;105.243;30.4106;38.8511;49.9875;31.9156;4.70178;133.304;245.492;22.3625;102.888;34.8042;1.73689;19.0606;110.58;36.7081;21.9073;15.4235;81.7848 0 Exp 2,28(0.37);Exp 3,4(0.06);Exp 4,4(0.06);Hill,8(0.11);Linear,14(0.19);Poly 2,17(0.23);Power,2(0.03) 1.9293330798318495 155.3973743915558 1.511321783065796 4.642963409423828 0.7286898596667193 1.7576230764389038 36.16290607261419 50.41997042089234 24.602143076883635 34.33641653870082 57.6724602794552 86.3343641361293 DOWN 0.33766233766233766 0.6623376623376623 0.0 GO:0048878 5 chemical homeostasis 274 291 37 37 29 32 25 25 137 266 2119 0.95839 0.06718 0.098058 8.59 24825;29573;246074;25106;83516;25513;25591;24567;24539;288001;81678;25675;81869;294515;25661;304929;24890;65030;25428;497840;113936;29184;155423;50681;25303 tf;slc37a4;scd;rgn;ppargc1a;pik3r1;parp1;mt1;lpl;kng1;itpr2;hmgcr;gstm7;foxo3;fn1;f5;esr1;ephx2;cyp7a1;cps1;cpb2;cd36;anxa7;acox1;abcc2 TF_10003;SLC37A4_9871;SCD1_9787;RGN_9699;PPARGC1A_33189;PIK3R1_32562;PARP1_9425;MT1A_9255;LPL_32544;KNG1L1_34113;ITPR2_8931;HMGCR_8810;GSTM7_8761;FOXO3_8662;FN1_8655;F5_33079;ESR1_33192;EPHX2_33282;CYP7A1_8430;CPS1_32421;CPB2_8369;CD36_8243;ANXA7_8051;ACOX1_7973;ABCC2_32541 38.97539880000001 31.9826 1.63089 27.579588908114683 46.576570329752904 24.637937795616754 25.196405200000004 24.4836 0.663137 16.56893440234819 30.203013579646175 14.20766963415737 71.22932800000001 45.5891 7.6286 80.34324234183981 80.95732822111034 73.16197251149978 13.5 39.22295 45.1539;39.7166;105.46;77.4407;42.4094;18.7324;26.9741;12.9315;74.2041;24.3655;31.8111;1.63089;42.3152;13.1992;59.5777;10.6089;23.3972;38.7293;5.72128;31.9826;25.8316;48.1296;104.64;23.1906;46.2316 28.132;22.6911;63.7532;58.7732;26.2988;11.6701;21.799;8.91033;49.8682;19.538;24.7342;0.663137;31.4035;5.6804;31.0499;2.59129;18.3088;29.2097;0.985273;24.4836;20.4374;37.5433;43.9254;16.2815;31.1788 61.5341;60.0334;422.699;89.8047;81.7305;41.5978;35.2797;23.4636;155.425;32.1467;44.3296;7.6286;64.5991;32.7581;105.243;37.5078;31.9156;57.2113;22.3625;45.5891;34.8042;69.1421;108.689;33.4539;81.7848 10 15 10 24825;246074;25106;25591;24539;81869;65030;29184;155423;50681 TF_10003;SCD1_9787;RGN_9699;PARP1_9425;LPL_32544;GSTM7_8761;EPHX2_33282;CD36_8243;ANXA7_8051;ACOX1_7973 58.623749999999994 46.64175 30.034211867921943 38.0689 34.4734 15.71695843228653 109.78379 66.8706 115.74004651347347 45.1539;105.46;77.4407;26.9741;74.2041;42.3152;38.7293;48.1296;104.64;23.1906 28.132;63.7532;58.7732;21.799;49.8682;31.4035;29.2097;37.5433;43.9254;16.2815 61.5341;422.699;89.8047;35.2797;155.425;64.5991;57.2113;69.1421;108.689;33.4539 15 29573;83516;25513;24567;288001;81678;25675;294515;25661;304929;24890;25428;497840;113936;25303 SLC37A4_9871;PPARGC1A_33189;PIK3R1_32562;MT1A_9255;KNG1L1_34113;ITPR2_8931;HMGCR_8810;FOXO3_8662;FN1_8655;F5_33079;ESR1_33192;CYP7A1_8430;CPS1_32421;CPB2_8369;ABCC2_32541 25.876498 24.3655 16.26220280308307 16.614742 19.538 10.703202722649484 45.52635333333334 37.5078 26.165604270406654 39.7166;42.4094;18.7324;12.9315;24.3655;31.8111;1.63089;13.1992;59.5777;10.6089;23.3972;5.72128;31.9826;25.8316;46.2316 22.6911;26.2988;11.6701;8.91033;19.538;24.7342;0.663137;5.6804;31.0499;2.59129;18.3088;0.985273;24.4836;20.4374;31.1788 60.0334;81.7305;41.5978;23.4636;32.1467;44.3296;7.6286;32.7581;105.243;37.5078;31.9156;22.3625;45.5891;34.8042;81.7848 0 Exp 2,9(0.36);Exp 3,1(0.04);Exp 4,2(0.08);Hill,2(0.08);Linear,4(0.16);Poly 2,5(0.2);Power,2(0.08) 2.1148987550488303 57.00764501094818 1.5461770296096802 5.973292827606201 1.1097705665565434 1.8344712257385254 28.164199948019043 49.786597651980955 18.701382914279506 31.69142748572049 39.73477700199879 102.7238789980012 DOWN 0.4 0.6 0.0 GO:0019216 6 regulation of lipid metabolic process 132 142 21 21 16 20 15 15 147 127 2258 0.98396 0.032966 0.048757 10.56 246273;25357;293615;25106;83516;29441;25513;24360;24890;65030;24330;25428;25146;29184;25287 trib3;thrsp;sirt3;rgn;ppargc1a;por;pik3r1;fabp1;esr1;ephx2;egr1;cyp7a1;cyp17a1;cd36;acadl TRIB3_10079;THRSP_33314;SIRT3_9828;RGN_9699;PPARGC1A_33189;POR_9531;PIK3R1_32562;FABP1_33091;ESR1_33192;EPHX2_33282;EGR1_8533;CYP7A1_8430;CYP17A1_32365;CD36_8243;ACADL_32776 35.161905133333335 33.4878 0.750017 28.797512600617456 36.27009162703548 28.44301395318557 25.936679466666668 26.2988 0.186019 22.638534639238415 26.922940687779075 22.24358793883532 56.69701 46.9257 4.70178 35.72998527095355 58.971315467218794 35.17626683649596 6.5 32.84655 13.5 92.75235 108.064;32.2053;2.38018;77.4407;42.4094;12.4414;18.7324;33.8478;23.3972;38.7293;0.750017;5.72128;49.6922;48.1296;33.4878 83.8836;24.3966;0.56209;58.7732;26.2988;8.48981;11.6701;26.4736;18.3088;29.2097;0.186019;0.985273;35.6654;37.5433;26.6039 143.428;46.6068;8.82917;89.8047;81.7305;79.2355;41.5978;46.9257;31.9156;57.2113;4.70178;22.3625;81.6409;69.1421;45.3228 7 8 7 293615;25106;24360;65030;25146;29184;25287 SIRT3_9828;RGN_9699;FABP1_33091;EPHX2_33282;CYP17A1_32365;CD36_8243;ACADL_32776 40.52965428571429 38.7293 22.57208920642103 30.690170000000002 29.2097 17.343322150594446 56.98238142857143 57.2113 27.046480810265898 2.38018;77.4407;33.8478;38.7293;49.6922;48.1296;33.4878 0.56209;58.7732;26.4736;29.2097;35.6654;37.5433;26.6039 8.82917;89.8047;46.9257;57.2113;81.6409;69.1421;45.3228 8 246273;25357;83516;29441;25513;24890;24330;25428 TRIB3_10079;THRSP_33314;PPARGC1A_33189;POR_9531;PIK3R1_32562;ESR1_33192;EGR1_8533;CYP7A1_8430 30.465124625 21.064799999999998 34.1739079395261 21.77737525 14.989450000000001 26.922461071339377 56.44731 44.1023 43.88736274417175 108.064;32.2053;42.4094;12.4414;18.7324;23.3972;0.750017;5.72128 83.8836;24.3966;26.2988;8.48981;11.6701;18.3088;0.186019;0.985273 143.428;46.6068;81.7305;79.2355;41.5978;31.9156;4.70178;22.3625 0 Exp 2,6(0.4);Hill,3(0.2);Linear,2(0.14);Poly 2,4(0.27) 2.3281697143434723 37.57838582992554 1.5209722518920898 4.642963409423828 1.0860917665123506 1.90940523147583 20.588353002653093 49.735457264013576 14.480000228332813 37.39335870500052 38.61514264582044 74.77887735417954 CONFLICT 0.4666666666666667 0.5333333333333333 0.0 GO:0072347 5 response to anesthetic 42 44 5 5 5 4 4 4 158 40 2345 0.85591 0.30563 0.35972 9.09 63868;361969;24330;312382 hspd1;fga;egr1;abcg2 HSPD1_8849;FGA_8632;EGR1_8533;ABCG2_32656 19.20118925 16.89842 0.750017 19.626477023947583 19.06906572105899 18.697672878343738 12.348899750000001 12.63134 0.186019 12.629808257696821 12.644059487047848 12.44861040925898 39.33047 25.11855 4.70178 44.5566714409668 37.11225560566405 41.3213583769605 1.5 16.89842 42.2579;28.5803;0.750017;5.21654 23.9469;22.529;0.186019;2.73368 102.383;38.8511;4.70178;11.386 2 2 2 63868;312382 HSPD1_8849;ABCG2_32656 23.73722 23.73722 26.192196840372134 13.34029 13.34029 15.000011712802094 56.884499999999996 56.884499999999996 64.34459576763226 42.2579;5.21654 23.9469;2.73368 102.383;11.386 2 361969;24330 FGA_8632;EGR1_8533 14.6651585 14.6651585 19.678981831640694 11.3575095 11.3575095 15.798873377022186 21.77644 21.77644 24.147215744909396 28.5803;0.750017 22.529;0.186019 38.8511;4.70178 0 Exp 3,1(0.25);Exp 4,1(0.25);Hill,1(0.25);Linear,1(0.25) 2.167666032021197 9.519468069076538 1.5074360370635986 4.21828556060791 1.2727270468329848 1.8968732357025146 -0.03275823346863049 38.435136733468624 -0.028312342542887947 24.726111842542885 -4.335068012147467 82.99600801214748 CONFLICT 0.5 0.5 0.0 GO:1904469 7 positive regulation of tumor necrosis factor secretion 9 9 4 4 3 4 3 3 159 6 2379 0.99846 0.01596 0.01596 33.33 24539;63868;65210 lpl;hspd1;cyp2j4 LPL_32544;HSPD1_8849;CYP2J4_32580 44.76716666666667 42.2579 17.8395 28.265957399199003 46.93500729129344 29.484527159244248 29.488400000000002 23.9469 14.6501 18.25129607973088 31.195743685059114 19.087330340247014 93.47430000000001 102.383 22.6149 66.85173421288334 97.26634067986383 69.08391250074051 0.0 17.8395 0.0 17.8395 74.2041;42.2579;17.8395 49.8682;23.9469;14.6501 155.425;102.383;22.6149 3 0 3 24539;63868;65210 LPL_32544;HSPD1_8849;CYP2J4_32580 44.76716666666667 42.2579 28.265957399199003 29.488400000000002 23.9469 18.25129607973088 93.47430000000001 102.383 66.85173421288334 74.2041;42.2579;17.8395 49.8682;23.9469;14.6501 155.425;102.383;22.6149 0 0 Exp 2,1(0.34);Exp 3,1(0.34);Linear,1(0.34) 2.3735433924427083 7.619229793548584 1.559399127960205 3.8079800605773926 1.1516035299442824 2.2518506050109863 12.781224764539783 76.75310856879354 8.835114218803312 50.14168578119669 17.824441182541022 169.12415881745898 UP 1.0 0.0 0.0 GO:0055081 7 anion homeostasis 21 21 4 4 2 3 2 2 160 19 2366 0.85485 0.39001 0.39001 9.52 497840;25303 cps1;abcc2 CPS1_32421;ABCC2_32541 39.1071 39.1071 31.9826 10.075564525127092 37.662323977596955 9.866217359767553 27.8312 27.8312 24.4836 4.734221321400174 27.152340822149426 4.635855040151236 63.68695 63.68695 45.5891 25.5942249197939 60.01689038359929 25.062435517505648 0.5 39.1071 31.9826;46.2316 24.4836;31.1788 45.5891;81.7848 0 2 0 2 497840;25303 CPS1_32421;ABCC2_32541 39.1071 39.1071 10.075564525127092 27.8312 27.8312 4.734221321400174 63.68695 63.68695 25.5942249197939 31.9826;46.2316 24.4836;31.1788 45.5891;81.7848 0 Exp 2,2(1) 1.842649196434199 3.6854416131973267 1.8264755010604858 1.8589661121368408 0.02297433141698536 1.8427208065986633 25.143080000000005 53.07112 21.269904 34.392496 28.215164 99.158736 DOWN 0.0 1.0 0.0 GO:0006811 5 ion transport 243 256 34 33 25 30 21 21 141 235 2150 0.91674 0.12881 0.22262 8.2 24825;170698;29573;25351;65192;361074;29482;29500;298199;100359982;81678;24360;304929;25428;83842;170945;29184;65054;312382;140668;25303 tf;slco1a2;slc37a4;slc2a2;slc27a2;slc25a30;slc1a2;slc10a2;plin2;mpc2;itpr2;fabp1;f5;cyp7a1;crot;chrna2;cd36;aqp9;abcg2;abcc3;abcc2 TF_10003;SLCO1A2_9886;SLC37A4_9871;SLC2A2_9863;SLC27A2_9860;SLC25A30_9856;SLC1A2_33059;SLC10A2_9833;PLIN2_9502;MPC2_33219;ITPR2_8931;FABP1_33091;F5_33079;CYP7A1_8430;CROT_8384;CHRNA2_32401;CD36_8243;AQP9_32709;ABCG2_32656;ABCC3_7941;ABCC2_32541 34.55688142857143 33.8478 5.21654 23.293311943438674 34.563245602948236 19.001061809324742 25.014471095238097 24.7342 0.985273 18.13356904985528 25.06618382688329 14.594699232204555 52.89062380952381 46.9257 10.316 32.1924442588615 52.56640082665237 28.83527963014771 11.5 38.71705 45.1539;104.197;39.7166;29.7555;7.62189;53.013;13.3235;56.585;25.6517;46.8463;31.8111;33.8478;10.6089;5.72128;7.4229;49.3913;48.1296;27.7316;5.21654;37.7175;46.2316 28.132;80.3101;22.6911;23.3399;5.49916;37.4804;9.10952;35.2796;20.9252;35.8494;24.7342;26.4736;2.59129;0.985273;5.75707;41.8524;37.5433;21.9372;2.73368;30.9007;31.1788 61.5341;128.412;60.0334;40.808;13.3925;90.2594;24.6773;116.8;33.0375;69.127;44.3296;46.9257;37.5078;22.3625;10.316;62.472;69.1421;37.4625;11.386;48.9329;81.7848 11 10 11 24825;65192;361074;298199;100359982;24360;83842;170945;29184;312382;140668 TF_10003;SLC27A2_9860;SLC25A30_9856;PLIN2_9502;MPC2_33219;FABP1_33091;CROT_8384;CHRNA2_32401;CD36_8243;ABCG2_32656;ABCC3_7941 32.72840272727272 37.7175 18.395254330994238 24.83153727272727 28.132 14.227651763722712 46.95683636363637 48.9329 26.914837357646153 45.1539;7.62189;53.013;25.6517;46.8463;33.8478;7.4229;49.3913;48.1296;5.21654;37.7175 28.132;5.49916;37.4804;20.9252;35.8494;26.4736;5.75707;41.8524;37.5433;2.73368;30.9007 61.5341;13.3925;90.2594;33.0375;69.127;46.9257;10.316;62.472;69.1421;11.386;48.9329 10 170698;29573;25351;29482;29500;81678;304929;25428;65054;25303 SLCO1A2_9886;SLC37A4_9871;SLC2A2_9863;SLC1A2_33059;SLC10A2_9833;ITPR2_8931;F5_33079;CYP7A1_8430;AQP9_32709;ABCC2_32541 36.568208 30.7833 28.655972391120144 25.2156983 23.0155 22.488250626401925 59.417790000000004 42.568799999999996 37.51982808321932 104.197;39.7166;29.7555;13.3235;56.585;31.8111;10.6089;5.72128;27.7316;46.2316 80.3101;22.6911;23.3399;9.10952;35.2796;24.7342;2.59129;0.985273;21.9372;31.1788 128.412;60.0334;40.808;24.6773;116.8;44.3296;37.5078;22.3625;37.4625;81.7848 0 Exp 2,8(0.39);Exp 4,1(0.05);Hill,3(0.15);Linear,4(0.2);Poly 2,5(0.24) 2.182029518251982 49.48176300525665 1.5074360370635986 5.963563919067383 1.1247441419332378 1.8753424882888794 24.594167346315615 44.51959551082726 17.258615501442204 32.77032668903398 39.121687964815074 66.65955965423255 CONFLICT 0.5238095238095238 0.47619047619047616 0.0 GO:1903076 8 regulation of protein localization to plasma membrane 27 29 2 2 2 2 2 2 160 27 2358 0.72053 0.55973 0.70682 6.9 362895;25513 stac3;pik3r1 STAC3_9953;PIK3R1_32562 40.98585 40.98585 18.7324 31.47113079959156 46.4075243516688 30.52282700298112 27.1866 27.1866 11.6701 21.94364474056213 30.96693114315618 21.28242790182 81.5589 81.5589 41.5978 56.5135295873475 91.29474190022097 54.81063575080843 0.5 40.98585 63.2393;18.7324 42.7031;11.6701 121.52;41.5978 0 2 0 2 362895;25513 STAC3_9953;PIK3R1_32562 40.98585 40.98585 31.47113079959156 27.1866 27.1866 21.94364474056213 81.5589 81.5589 56.5135295873475 63.2393;18.7324 42.7031;11.6701 121.52;41.5978 0 Linear,1(0.5);Poly 2,1(0.5) 2.1951057956448445 4.552730917930603 1.6735800504684448 2.879150867462158 0.852467299896861 2.2763654589653015 -2.630911999999995 84.602612 -3.2257399999999947 57.59893999999999 3.235143999999991 159.882656 DOWN 0.0 1.0 0.0 GO:1990637 6 response to prolactin 4 4 2 2 2 1 1 1 161 3 2382 0.97784 0.23128 0.23128 25.0 29540 hsd17b7 HSD17B7_8834 0.977494 0.977494 0.977494 0.9774939999999999 0.322682 0.322682 0.322682 0.322682 5.49472 5.49472 5.49472 5.49472 0.0 0.977494 0.0 0.977494 0.977494 0.322682 5.49472 0 1 0 1 29540 HSD17B7_8834 0.977494 0.977494 0.322682 0.322682 5.49472 5.49472 0.977494 0.322682 5.49472 0 Exp 4,1(1) 1.7248681783676147 1.7248681783676147 1.7248681783676147 1.7248681783676147 0.0 1.7248681783676147 0.977494 0.977494 0.322682 0.322682 5.49472 5.49472 DOWN 0.0 1.0 0.0 GO:0031348 6 negative regulation of defense response 64 68 4 4 2 4 2 2 160 66 2319 0.18106 0.93803 0.3187 2.94 79426;65164 zfp36;htra1 ZFP36_10204;HTRA1_8856 16.740217 16.740217 0.348134 23.181906094145447 25.4449091953531 19.643254254987788 12.866301 12.866301 0.118102 18.028675921631127 19.635980505655763 15.276649968779502 23.91126 23.91126 1.15962 32.17567785423021 35.993069440538065 27.26415241052343 0.348134;33.1323 0.118102;25.6145 1.15962;46.6629 0 2 0 2 79426;65164 ZFP36_10204;HTRA1_8856 16.740217 16.740217 23.181906094145447 12.866301 12.866301 18.028675921631127 23.91126 23.91126 32.17567785423021 0.348134;33.1323 0.118102;25.6145 1.15962;46.6629 0 Hill,1(0.5);Linear,1(0.5) 1.7390101890189162 3.498486638069153 1.5603101253509521 1.9381765127182007 0.2671918848898442 1.7492433190345764 -15.388265679999996 48.86869968 -12.120169039999997 37.85277103999999 -20.6819544 68.5044744 DOWN 0.0 1.0 0.0 GO:0050679 7 positive regulation of epithelial cell proliferation 67 70 9 9 6 7 4 4 158 66 2319 0.5373 0.6612 1.0 5.71 24516;65164;24957;24890 jun;htra1;glul;esr1 JUN_8938;HTRA1_8856;GLUL_32832;ESR1_33192 24.8572 24.93205 16.4324 6.932466351402896 26.99921703534644 7.4084550183296365 18.872825 19.6772 10.5224 6.330320025809658 20.58788890449438 6.61134303222347 38.48445 37.67965 31.9156 6.362687892445037 40.95265303721911 6.369047177648869 2.5 29.799599999999998 16.4324;33.1323;26.4669;23.3972 10.5224;25.6145;21.0456;18.3088 39.929;46.6629;35.4303;31.9156 0 4 0 4 24516;65164;24957;24890 JUN_8938;HTRA1_8856;GLUL_32832;ESR1_33192 24.8572 24.93205 6.932466351402896 18.872825 19.6772 6.330320025809658 38.48445 37.67965 6.362687892445037 16.4324;33.1323;26.4669;23.3972 10.5224;25.6145;21.0456;18.3088 39.929;46.6629;35.4303;31.9156 0 Exp 2,1(0.25);Linear,2(0.5);Poly 2,1(0.25) 2.0532060577440414 8.33806824684143 1.5603101253509521 2.436986207962036 0.40307579780569097 2.170385956764221 18.063382975625167 31.65101702437483 12.669111374706542 25.076538625293455 32.24901586540386 44.71988413459614 DOWN 0.0 1.0 0.0 GO:1901653 6 cellular response to peptide 127 135 25 24 18 21 15 15 147 120 2265 0.98991 0.021918 0.028171 11.11 286954;246273;29441;24651;25513;25591;58954;294515;25661;29496;24330;497840;29184;25698;25373 ugt2b1;trib3;por;pklr;pik3r1;parp1;klf6;foxo3;fn1;erbb3;egr1;cps1;cd36;ass1;ahsg UGT2B10_33303,UGT2B1_33224;TRIB3_10079;POR_9531;PKLR_9489;PIK3R1_32562;PARP1_9425;KLF6_8969;FOXO3_8662;FN1_8655;ERBB3_8571;EGR1_8533;CPS1_32421;CD36_8243;ASS1_33159;AHSG_8003 33.971497799999995 26.8037 0.750017 27.25939173130679 36.80791556600777 25.228194273306336 24.110591933333332 20.9825 0.186019 20.593791158538863 25.844119780917605 18.32546686027177 58.53638866666666 45.5481 4.70178 38.767505028304846 63.01579067721915 37.60728136644569 5.5 21.02195 12.5 60.28805 47.47345;108.064;12.4414;23.0963;18.7324;26.9741;18.9476;13.1992;59.5777;60.9984;0.750017;31.9826;48.1296;26.8037;12.402 34.82915;83.8836;8.48981;17.4625;11.6701;21.799;11.6941;5.6804;31.0499;41.6036;0.186019;24.4836;37.5433;20.9825;10.3013 76.47475;143.428;79.2355;32.9443;41.5978;35.2797;45.5481;32.7581;105.243;113.972;4.70178;45.5891;69.1421;36.7081;15.4235 5 11 4 286954;25591;29496;29184 UGT2B10_33303,UGT2B1_33224;PARP1_9425;ERBB3_8571;CD36_8243 45.893887500000005 47.801525 14.066485997835107 33.9437625 36.186225 8.561716104202391 73.71713749999999 72.808425 32.282223959360245 47.47345;26.9741;60.9984;48.1296 34.82915;21.799;41.6036;37.5433 76.47475;35.2797;113.972;69.1421 11 246273;29441;24651;25513;58954;294515;25661;24330;497840;25698;25373 TRIB3_10079;POR_9531;PKLR_9489;PIK3R1_32562;KLF6_8969;FOXO3_8662;FN1_8655;EGR1_8533;CPS1_32421;ASS1_33159;AHSG_8003 29.63608336363636 18.9476 30.056807106793375 20.534893545454544 11.6941 22.78188655456304 53.016116363636364 41.5978 40.813500566025276 108.064;12.4414;23.0963;18.7324;18.9476;13.1992;59.5777;0.750017;31.9826;26.8037;12.402 83.8836;8.48981;17.4625;11.6701;11.6941;5.6804;31.0499;0.186019;24.4836;20.9825;10.3013 143.428;79.2355;32.9443;41.5978;45.5481;32.7581;105.243;4.70178;45.5891;36.7081;15.4235 0 Exp 2,8(0.5);Exp 4,1(0.07);Hill,1(0.07);Linear,1(0.07);Poly 2,4(0.25);Power,1(0.07) 2.05944519390798 34.423930644989014 1.5740432739257812 4.21828556060791 0.7442694538759647 1.851805865764618 20.17634222679554 47.76665337320446 13.68869566820685 34.532488198459816 38.9173242237781 78.15545310955522 DOWN 0.26666666666666666 0.7333333333333333 0.0 GO:0031668 4 cellular response to extracellular stimulus 98 103 15 15 13 10 8 8 154 95 2290 0.79515 0.33086 0.53403 7.77 29482;24539;24516;24957;294515;314322;114851;246142 slc1a2;lpl;jun;glul;foxo3;fos;cdkn1a;bmf SLC1A2_33059;LPL_32544;JUN_8938;GLUL_32832;FOXO3_8662;FOS_8657;CDKN1A_8271;BMF_8152 30.594058750000162 14.87795 1.28141E-12 34.60218549390281 42.16644817995095 39.42312609928683 21.475071250000163 9.81596 1.28141E-12 26.242991987827455 30.1506358280867 30.04029455954535 52.14103750000017 34.0942 1.28142E-12 52.60229668904827 68.87156302076365 59.08378915790335 4.5 21.44965 13.3235;74.2041;16.4324;26.4669;13.1992;1.28141E-12;6.24967;94.8767 9.10952;49.8682;10.5224;21.0456;5.6804;1.28141E-12;2.44025;73.1342 24.6773;155.425;39.929;35.4303;32.7581;1.28142E-12;19.0606;109.848 2 6 2 24539;246142 LPL_32544;BMF_8152 84.5404 84.5404 14.617735644756898 61.501200000000004 61.501200000000004 16.45154637108624 132.6365 132.6365 32.227805766139305 74.2041;94.8767 49.8682;73.1342 155.425;109.848 6 29482;24516;24957;294515;314322;114851 SLC1A2_33059;JUN_8938;GLUL_32832;FOXO3_8662;FOS_8657;CDKN1A_8271 12.611945000000214 13.26135 9.021602222119055 8.133028333333547 7.394959999999999 7.456090138243536 25.309216666666885 28.7177 14.502835810063262 13.3235;16.4324;26.4669;13.1992;1.28141E-12;6.24967 9.10952;10.5224;21.0456;5.6804;1.28141E-12;2.44025 24.6773;39.929;35.4303;32.7581;1.28142E-12;19.0606 0 Exp 2,1(0.13);Exp 4,2(0.25);Hill,1(0.13);Linear,1(0.13);Poly 2,3(0.38) 1.8102454987496195 14.628779530525208 1.522104263305664 2.3622660636901855 0.2837123300455904 1.7989229559898376 6.615967543518963 54.572149956481354 3.2896056086474736 39.66053689135285 15.689505619083704 88.59256938091661 DOWN 0.25 0.75 0.0 GO:0051099 5 positive regulation of binding 56 61 4 4 3 3 2 2 160 59 2326 0.2432 0.90929 0.43166 3.28 246273;25591 trib3;parp1 TRIB3_10079;PARP1_9425 67.51905 67.51905 26.9741 57.33921817573904 54.68758306513409 54.39202932051613 52.841300000000004 52.841300000000004 21.799 43.90044166725432 43.01718513409961 41.643994918633716 89.35385 89.35385 35.2797 76.47239630379713 72.2407281992337 72.54177776226109 108.064;26.9741 83.8836;21.799 143.428;35.2797 1 1 1 25591 PARP1_9425 26.9741 26.9741 21.799 21.799 35.2797 35.2797 26.9741 21.799 35.2797 1 246273 TRIB3_10079 108.064 108.064 83.8836 83.8836 143.428 143.428 108.064 83.8836 143.428 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.842584976910705 3.685805916786194 1.8086696863174438 1.87713623046875 0.04841315765379674 1.842902958393097 -11.949051999999995 146.98715199999998 -8.00160799999999 113.684208 -16.631483999999986 195.339184 CONFLICT 0.5 0.5 0.0 GO:0072216 7 positive regulation of metanephros development 8 8 4 4 3 3 2 2 160 6 2379 0.98885 0.087405 0.087405 25.0 81819;24330 pax8;egr1 PAX8_9432;EGR1_8533 28.8215585 28.8215585 0.750017 39.69915470601918 32.48457350092764 39.35971959476341 22.6511095 22.6511095 0.186019 31.770435665038978 25.58254678849721 31.498792567233387 43.13529 43.13529 4.70178 54.353191091601964 48.150423339517616 53.88846126040266 0.0 0.750017 0.0 0.750017 56.8931;0.750017 45.1162;0.186019 81.5688;4.70178 1 1 1 81819 PAX8_9432 56.8931 56.8931 45.1162 45.1162 81.5688 81.5688 56.8931 45.1162 81.5688 1 24330 EGR1_8533 0.750017 0.750017 0.186019 0.186019 4.70178 4.70178 0.750017 0.186019 4.70178 0 Exp 2,1(0.5);Hill,1(0.5) 2.718689287519916 5.9704835414886475 1.7521979808807373 4.21828556060791 1.7437872506250045 2.9852417707443237 -26.198662839999987 83.84177983999999 -21.380467879999994 66.68268687999999 -32.194389599999994 118.46496959999999 CONFLICT 0.5 0.5 0.0 GO:0044265 5 cellular macromolecule catabolic process 99 104 4 4 4 4 4 4 158 100 2285 0.19624 0.90798 0.40904 3.85 79426;312688;29676;308441 zfp36;usp18;psmb3;exosc5 ZFP36_10204;USP18_10138;PSMB3_9589;EXOSC5_32543 43.7382085 32.86085 0.348134 46.6468307711398 47.45869684905829 49.69601260321395 31.0663755 25.503 0.118102 30.917343384872744 33.46558169793638 32.62484483591719 58.085480000000004 46.51915 1.15962 58.89350094170777 61.58045261061548 62.62320787098751 0.348134;108.883;23.7888;41.9329 0.118102;73.1414;19.2724;31.7336 1.15962;138.144;30.901;62.1373 3 1 3 312688;29676;308441 USP18_10138;PSMB3_9589;EXOSC5_32543 58.20156666666666 41.9329 44.81916838522703 41.382466666666666 31.7336 28.200935466989982 77.06076666666667 62.1373 55.15702725186822 108.883;23.7888;41.9329 73.1414;19.2724;31.7336 138.144;30.901;62.1373 1 79426 ZFP36_10204 0.348134 0.348134 0.118102 0.118102 1.15962 1.15962 0.348134 0.118102 1.15962 0 Exp 2,2(0.5);Hill,1(0.25);Power,1(0.25) 1.712373651452076 6.869361996650696 1.5979743003845215 1.9381765127182007 0.15401883635070887 1.6666055917739868 -1.9756856557170153 89.45210265571701 0.7673789828247095 61.3653720171753 0.36984907712638915 115.80111092287362 UP 0.75 0.25 0.0 GO:0007568 3 aging 181 193 22 22 18 22 18 18 144 175 2210 0.96638 0.059939 0.08995 9.33 29482;293615;25106;83516;25513;24314;24516;25685;24471;24464;25675;29328;294515;314322;25423;114851;25698;312382 slc1a2;sirt3;rgn;ppargc1a;pik3r1;nqo1;jun;igfbp1;hspb1;hp;hmgcr;gpx4;foxo3;fos;ctsc;cdkn1a;ass1;abcg2 SLC1A2_33059;SIRT3_9828;RGN_9699;PPARGC1A_33189;PIK3R1_32562;NQO1_33055;JUN_8938;IGFBP1_32306;HSPB1_8847;HP_8823;HMGCR_8810;GPX4_32827;FOXO3_8662;FOS_8657;CTSC_32456;CDKN1A_8271;ASS1_33159;ABCG2_32656 34.23942111111118 22.76805 1.28141E-12 30.58848002383259 35.496974885828664 30.404655635045085 23.180459833333405 16.3263 1.28141E-12 21.760168620586494 23.953268490254267 21.48905218696078 60.90552055555564 40.763400000000004 1.28142E-12 52.688821967366934 60.231351052613036 46.89756728610057 8.5 22.76805 13.3235;2.38018;77.4407;42.4094;18.7324;87.2765;16.4324;49.0259;89.1011;64.9285;1.63089;45.9204;13.1992;1.28141E-12;56.2386;6.24967;26.8037;5.21654 9.10952;0.56209;58.7732;26.2988;11.6701;60.6992;10.5224;32.6883;60.3265;41.6103;0.663137;34.2198;5.6804;1.28141E-12;38.2681;2.44025;20.9825;2.73368 24.6773;8.82917;89.8047;81.7305;41.5978;197.117;39.929;89.1623;106.138;136.455;7.6286;70.4292;32.7581;1.28142E-12;102.888;19.0606;36.7081;11.386 5 13 5 293615;25106;24314;29328;312382 SIRT3_9828;RGN_9699;NQO1_33055;GPX4_32827;ABCG2_32656 43.646864 45.9204 39.46696867676666 31.397593999999998 34.2198 29.10507274293573 75.51321399999999 70.4292 76.7734261310024 2.38018;77.4407;87.2765;45.9204;5.21654 0.56209;58.7732;60.6992;34.2198;2.73368 8.82917;89.8047;197.117;70.4292;11.386 13 29482;83516;25513;24516;25685;24471;24464;25675;294515;314322;25423;114851;25698 SLC1A2_33059;PPARGC1A_33189;PIK3R1_32562;JUN_8938;IGFBP1_32306;HSPB1_8847;HP_8823;HMGCR_8810;FOXO3_8662;FOS_8657;CTSC_32456;CDKN1A_8271;ASS1_33159 30.621173846153948 18.7324 27.48162753804504 20.020023615384712 11.6701 18.694267845934238 55.28717692307703 39.929 42.9534522667687 13.3235;42.4094;18.7324;16.4324;49.0259;89.1011;64.9285;1.63089;13.1992;1.28141E-12;56.2386;6.24967;26.8037 9.10952;26.2988;11.6701;10.5224;32.6883;60.3265;41.6103;0.663137;5.6804;1.28141E-12;38.2681;2.44025;20.9825 24.6773;81.7305;41.5978;39.929;89.1623;106.138;136.455;7.6286;32.7581;1.28142E-12;102.888;19.0606;36.7081 0 Exp 2,7(0.39);Exp 4,4(0.23);Hill,2(0.12);Poly 2,5(0.28) 1.7799888583781798 32.953941822052 1.5074360370635986 3.9562058448791504 0.5544433799492344 1.6854488253593445 20.108264299097556 48.37057792312481 13.127774809632172 33.23314485703463 36.56452666239642 85.2465144487148 DOWN 0.2777777777777778 0.7222222222222222 0.0 GO:0009612 4 response to mechanical stimulus 121 126 9 9 8 8 7 7 155 119 2266 0.44284 0.70261 0.85207 5.56 25493;24516;24471;25112;314322;24330;29184 nfkbia;jun;hspb1;gadd45a;fos;egr1;cd36 NFKBIA_9307;JUN_8938;HSPB1_8847;GADD45A_8678;FOS_8657;EGR1_8533;CD36_8243 36.83603828571447 16.4324 1.28141E-12 44.00830568310701 52.81055068534963 44.069359684735005 28.319945857143043 10.5224 1.28141E-12 35.48684407548937 41.38719452829852 36.46435500370131 48.31898142857161 39.929 1.28142E-12 49.41877710751916 66.58851705007056 47.74174943541668 5.5 96.01005 0.520151;16.4324;89.1011;102.919;1.28141E-12;0.750017;48.1296 0.160202;10.5224;60.3265;89.5012;1.28141E-12;0.186019;37.5433 2.88499;39.929;106.138;115.437;1.28142E-12;4.70178;69.1421 1 6 1 29184 CD36_8243 48.1296 48.1296 37.5433 37.5433 69.1421 69.1421 48.1296 37.5433 69.1421 6 25493;24516;24471;25112;314322;24330 NFKBIA_9307;JUN_8938;HSPB1_8847;GADD45A_8678;FOS_8657;EGR1_8533 34.95377800000021 8.5912085 47.899026828722306 26.782720166666877 5.3542095 38.61773679552767 44.84846166666688 22.31539 53.192901543851825 0.520151;16.4324;89.1011;102.919;1.28141E-12;0.750017 0.160202;10.5224;60.3265;89.5012;1.28141E-12;0.186019 2.88499;39.929;106.138;115.437;1.28142E-12;4.70178 0 Exp 2,1(0.15);Exp 4,1(0.15);Hill,2(0.29);Poly 2,3(0.43) 2.1572360118240086 15.949657559394836 1.6339634656906128 4.21828556060791 0.9205941928687416 1.8966681957244873 4.23422919724721 69.43784737418173 2.0309238704272445 54.608967843858835 11.709039018011886 84.92892383913136 DOWN 0.14285714285714285 0.8571428571428571 0.0 GO:0007610 2 behavior 142 151 10 10 9 9 8 8 154 143 2242 0.36677 0.75861 0.7308 5.3 29482;25591;24516;25675;29455;314322;24330;29184 slc1a2;parp1;jun;hmgcr;gdf15;fos;egr1;cd36 SLC1A2_33059;PARP1_9425;JUN_8938;HMGCR_8810;GDF15_33113;FOS_8657;EGR1_8533;CD36_8243 26.54868837500016 14.87795 1.28141E-12 35.682071492976974 35.742102522469345 37.496727944631324 20.646509500000157 9.81596 1.28141E-12 29.162226402980263 28.145242557704158 30.70378324980483 38.37631000000016 29.978499999999997 1.28142E-12 41.944486142297144 49.21660291252539 43.49481381962128 6.5 76.6393 13.3235;26.9741;16.4324;1.63089;105.149;1.28141E-12;0.750017;48.1296 9.10952;21.799;10.5224;0.663137;85.3487;1.28141E-12;0.186019;37.5433 24.6773;35.2797;39.929;7.6286;125.652;1.28142E-12;4.70178;69.1421 2 6 2 25591;29184 PARP1_9425;CD36_8243 37.55185 37.55185 14.959197509391997 29.67115 29.67115 11.132901295035358 52.210899999999995 52.210899999999995 23.944332667251356 26.9741;48.1296 21.799;37.5433 35.2797;69.1421 6 29482;24516;25675;29455;314322;24330 SLC1A2_33059;JUN_8938;HMGCR_8810;GDF15_33113;FOS_8657;EGR1_8533 22.880967833333546 7.477195 40.904380735471655 17.638296000000214 4.8863285 33.50200676714095 33.76478000000021 16.15295 47.39548363025303 13.3235;16.4324;1.63089;105.149;1.28141E-12;0.750017 9.10952;10.5224;0.663137;85.3487;1.28141E-12;0.186019 24.6773;39.929;7.6286;125.652;1.28142E-12;4.70178 0 Exp 2,2(0.25);Exp 4,1(0.13);Hill,2(0.25);Poly 2,3(0.38) 2.0925702045559125 17.655144929885864 1.5606178045272827 4.21828556060791 0.8801202016617758 1.8992191553115845 1.8222743499222922 51.275102400078026 0.43811761683633677 40.854901383163984 9.31026402708875 67.44235597291157 DOWN 0.25 0.75 0.0 GO:1903506 8 regulation of nucleic acid-templated transcription 474 508 35 35 27 29 24 24 138 484 1901 0.052771 0.96686 0.10363 4.72 79426;24522;246273;24825;293615;83516;363465;25513;81819;25591;81525;25493;58954;24516;494344;290556;25112;294515;314322;24890;24330;25695;29184;79431 zfp36;zfp354a;trib3;tf;sirt3;ppargc1a;pir;pik3r1;pax8;parp1;nfkbib;nfkbia;klf6;jun;ier2;gnl3;gadd45a;foxo3;fos;esr1;egr1;cebpd;cd36;bhlhe40 ZFP36_10204;ZFP354A_10203;TRIB3_10079;TF_10003;SIRT3_9828;PPARGC1A_33189;PIR_9487;PIK3R1_32562;PAX8_9432;PARP1_9425;NFKBIB_9308;NFKBIA_9307;KLF6_8969;JUN_8938;IER2_32643;GNL3_8735;GADD45A_8678;FOXO3_8662;FOS_8657;ESR1_33192;EGR1_8533;CEBPD_8283;CD36_8243;BHLHE40_8141 33.42106854166672 25.185650000000003 1.28141E-12 32.44870753052968 36.39596466230565 31.696080858560162 24.19824155000006 20.0539 1.28141E-12 25.358541999199367 27.488571262699026 26.14335597918161 56.47635916666672 41.42945 1.28142E-12 56.13212806489727 54.71318157900256 43.803629802413745 0.348134;0.834827;108.064;45.1539;2.38018;42.4094;50.0307;18.7324;56.8931;26.9741;30.5572;0.520151;18.9476;16.4324;49.6814;87.6357;102.919;13.1992;1.28141E-12;23.3972;0.750017;0.306936;48.1296;57.8085 0.118102;0.27095;83.8836;28.132;0.56209;26.2988;38.7717;11.6701;45.1162;21.799;24.2439;0.160202;11.6941;10.5224;33.4626;54.41;89.5012;5.6804;1.28141E-12;18.3088;0.186019;0.0732342;37.5433;38.3491 1.15962;2.99857;143.428;61.5341;8.82917;81.7305;73.0083;41.5978;81.5688;35.2797;41.2611;2.88499;45.5481;39.929;89.4404;238.963;115.437;32.7581;1.28142E-12;31.9156;4.70178;1.73689;69.1421;110.58 8 16 8 24825;293615;363465;81819;25591;81525;290556;29184 TF_10003;SIRT3_9828;PIR_9487;PAX8_9432;PARP1_9425;NFKBIB_9308;GNL3_8735;CD36_8243 43.46931 46.64175 24.858477342271556 31.32227375 32.837650000000004 16.538584723689485 76.19828375 65.3381 69.92826334708488 45.1539;2.38018;50.0307;56.8931;26.9741;30.5572;87.6357;48.1296 28.132;0.56209;38.7717;45.1162;21.799;24.2439;54.41;37.5433 61.5341;8.82917;73.0083;81.5688;35.2797;41.2611;238.963;69.1421 16 79426;24522;246273;83516;25513;25493;58954;24516;494344;25112;294515;314322;24890;24330;25695;79431 ZFP36_10204;ZFP354A_10203;TRIB3_10079;PPARGC1A_33189;PIK3R1_32562;NFKBIA_9307;KLF6_8969;JUN_8938;IER2_32643;GADD45A_8678;FOXO3_8662;FOS_8657;ESR1_33192;EGR1_8533;CEBPD_8283;BHLHE40_8141 28.39694781250008 17.5824 35.289200540627554 20.63622545000008 11.09625 28.59671833550186 46.61539687500008 36.34355 47.30861627705156 0.348134;0.834827;108.064;42.4094;18.7324;0.520151;18.9476;16.4324;49.6814;102.919;13.1992;1.28141E-12;23.3972;0.750017;0.306936;57.8085 0.118102;0.27095;83.8836;26.2988;11.6701;0.160202;11.6941;10.5224;33.4626;89.5012;5.6804;1.28141E-12;18.3088;0.186019;0.0732342;38.3491 1.15962;2.99857;143.428;81.7305;41.5978;2.88499;45.5481;39.929;89.4404;115.437;32.7581;1.28142E-12;31.9156;4.70178;1.73689;110.58 0 Exp 2,10(0.42);Exp 4,2(0.09);Hill,6(0.25);Poly 2,6(0.25) 1.9535345071475307 49.11206769943237 1.5209722518920898 4.591650485992432 0.7746088728749797 1.8215704560279846 20.438881752108117 46.403255331225324 14.052711758567428 34.34377134143269 34.01883075052564 78.93388758280781 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0008037 3 cell recognition 38 40 2 2 2 2 2 2 160 38 2347 0.527 0.73412 1.0 5.0 83928;29184 fetub;cd36 FETUB_33027;CD36_8243 40.32255000000001 40.32255000000001 32.5155 11.040835992124824 40.14258507135017 11.037902185375275 28.57635 28.57635 19.6094 12.681182303121426 28.36964753018661 12.677812618229764 59.5648 59.5648 49.9875 13.54434755091588 59.34402799121844 13.540748502954997 1.0 48.1296 32.5155;48.1296 19.6094;37.5433 49.9875;69.1421 1 1 1 29184 CD36_8243 48.1296 48.1296 37.5433 37.5433 69.1421 69.1421 48.1296 37.5433 69.1421 1 83928 FETUB_33027 32.5155 32.5155 19.6094 19.6094 49.9875 49.9875 32.5155 19.6094 49.9875 0 Exp 2,1(0.5);Poly 2,1(0.5) 2.3998572498338486 4.827106475830078 2.1567957401275635 2.6703107357025146 0.3631099356120279 2.413553237915039 25.02073200000001 55.624368000000004 11.001128000000001 46.151572 40.793291999999994 78.336308 CONFLICT 0.5 0.5 0.0 GO:0032760 8 positive regulation of tumor necrosis factor production 43 45 7 7 6 7 6 6 156 39 2346 0.97843 0.062517 0.062517 13.33 25513;24539;63868;24471;65210;29184 pik3r1;lpl;hspd1;hspb1;cyp2j4;cd36 PIK3R1_32562;LPL_32544;HSPD1_8849;HSPB1_8847;CYP2J4_32580;CD36_8243 48.37743333333333 45.19375 17.8395 28.89407282150904 52.02453284057971 27.856202943714443 33.00085000000001 30.7451 11.6701 19.624257579205377 35.89576039130435 18.63402245953613 82.88346666666668 85.76255 22.6149 48.39196366578509 88.33039976570046 49.75240885361416 1.5 30.49515 3.5 61.16685 18.7324;74.2041;42.2579;89.1011;17.8395;48.1296 11.6701;49.8682;23.9469;60.3265;14.6501;37.5433 41.5978;155.425;102.383;106.138;22.6149;69.1421 4 2 4 24539;63868;65210;29184 LPL_32544;HSPD1_8849;CYP2J4_32580;CD36_8243 45.607775000000004 45.19375 23.140211493037384 31.502125 30.7451 15.436759997783433 87.39125 85.76255 55.92361070296398 74.2041;42.2579;17.8395;48.1296 49.8682;23.9469;14.6501;37.5433 155.425;102.383;22.6149;69.1421 2 25513;24471 PIK3R1_32562;HSPB1_8847 53.91675 53.91675 49.758184953281805 35.9983 35.9983 34.40527038812513 73.8679 73.8679 45.63681307913602 18.7324;89.1011 11.6701;60.3265 41.5978;106.138 0 Exp 2,2(0.34);Exp 3,1(0.17);Linear,1(0.17);Poly 2,2(0.34) 2.159536202733653 13.660438179969788 1.559399127960205 3.8079800605773926 0.8618960143602394 1.9745841026306152 25.257359898851256 71.49750676781542 17.29817356766711 48.70352643233289 44.161831246724226 121.60510208660912 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0051702 3 interaction with symbiont 33 36 6 6 6 4 4 4 158 32 2353 0.92544 0.19254 0.28483 11.11 85253;24516;63868;25661 plg;jun;hspd1;fn1 PLG_9501;JUN_8938;HSPD1_8849;FN1_8655 47.263425 50.9178 16.4324 23.66816549029168 53.32917380016023 20.164937401259962 27.938699999999997 27.4984 10.5224 14.874117206073109 31.146678231738402 13.254209316474 99.5335 103.81299999999999 39.929 45.45715026630388 109.09864336173621 38.76863618275651 0.5 29.34515 2.5 65.1817 70.7857;16.4324;42.2579;59.5777 46.2356;10.5224;23.9469;31.0499 150.579;39.929;102.383;105.243 1 3 1 63868 HSPD1_8849 42.2579 42.2579 23.9469 23.9469 102.383 102.383 42.2579 23.9469 102.383 3 85253;24516;25661 PLG_9501;JUN_8938;FN1_8655 48.931933333333326 59.5777 28.69790177283583 29.269299999999998 31.0499 17.92305961129406 98.58366666666666 105.243 55.62477564299323 70.7857;16.4324;59.5777 46.2356;10.5224;31.0499 150.579;39.929;105.243 0 Exp 3,1(0.25);Linear,1(0.25);Poly 2,1(0.25);Power,1(0.25) 1.864783083871038 7.535059094429016 1.5254690647125244 2.2518506050109863 0.3075525089736628 1.8788697123527527 24.068622819514164 70.45822718048584 13.362065138048358 42.515334861951644 54.98549273902218 144.08150726097784 DOWN 0.25 0.75 0.0 GO:0061097 8 regulation of protein tyrosine kinase activity 24 26 2 2 2 2 2 2 160 24 2361 0.7731 0.50003 0.67957 7.69 29496;25373 erbb3;ahsg ERBB3_8571;AHSG_8003 36.700199999999995 36.700199999999995 12.402 34.362843981253945 42.96758301520873 33.20007329451768 25.95245 25.95245 10.3013 22.13406859673567 29.98944663672553 21.385095486229034 64.69775 64.69775 15.4235 69.68431262576246 77.40735801776053 67.32633328939542 0.5 36.700199999999995 60.9984;12.402 41.6036;10.3013 113.972;15.4235 1 1 1 29496 ERBB3_8571 60.9984 60.9984 41.6036 41.6036 113.972 113.972 60.9984 41.6036 113.972 1 25373 AHSG_8003 12.402 12.402 10.3013 10.3013 15.4235 15.4235 12.402 10.3013 15.4235 0 Exp 2,1(0.5);Linear,1(0.5) 2.344086600320337 5.03272271156311 1.6013026237487793 3.431420087814331 1.2940884692086794 2.516361355781555 -10.924271999999995 84.32467199999999 -4.723803999999998 56.628704 -31.879779999999982 161.27527999999998 CONFLICT 0.5 0.5 0.0 GO:0045765 6 regulation of angiogenesis 105 108 7 7 6 6 5 5 157 103 2282 0.30424 0.82963 0.54997 4.63 24794;24471;24957;25112;29184 serpina3c;hspb1;glul;gadd45a;cd36 SERPINA3C_32925;HSPB1_8847;GLUL_32832;GADD45A_8678;CD36_8243 59.276520000000005 48.1296 26.4669 34.87752647991252 67.68398905015674 33.75462311489826 46.35272 37.5433 21.0456 28.7418562811625 53.438658000000004 28.8661965176364 73.3946 69.1421 35.4303 36.60534535098664 82.94036918181818 34.08310105462572 29.766;89.1011;26.4669;102.919;48.1296 23.347;60.3265;21.0456;89.5012;37.5433 40.8256;106.138;35.4303;115.437;69.1421 1 4 1 29184 CD36_8243 48.1296 48.1296 37.5433 37.5433 69.1421 69.1421 48.1296 37.5433 69.1421 4 24794;24471;24957;25112 SERPINA3C_32925;HSPB1_8847;GLUL_32832;GADD45A_8678 62.06325 59.43355 39.625118849748155 48.555075 41.83675 32.69745076213893 74.457725 73.4818 42.17898583318278 29.766;89.1011;26.4669;102.919 23.347;60.3265;21.0456;89.5012 40.8256;106.138;35.4303;115.437 0 Exp 2,1(0.2);Linear,2(0.4);Poly 2,2(0.4) 1.9520607592887445 9.984065175056458 1.6202073097229004 2.6703107357025146 0.48742801179401013 1.6973176002502441 28.70502012231572 89.84801987768428 21.15937217787022 71.54606782212979 41.30860010649248 105.48059989350752 DOWN 0.2 0.8 0.0 GO:2000026 5 regulation of multicellular organismal development 487 514 39 39 31 32 26 26 136 488 1897 0.10305 0.93026 0.18943 5.06 79426;24825;24794;25106;29441;25513;81819;25493;307582;24516;24471;25675;24957;25112;294515;314322;25661;24890;29496;24330;116663;25423;113936;29184;79431;25373 zfp36;tf;serpina3c;rgn;por;pik3r1;pax8;nfkbia;lama3;jun;hspb1;hmgcr;glul;gadd45a;foxo3;fos;fn1;esr1;erbb3;egr1;dusp6;ctsc;cpb2;cd36;bhlhe40;ahsg ZFP36_10204;TF_10003;SERPINA3C_32925;RGN_9699;POR_9531;PIK3R1_32562;PAX8_9432;NFKBIA_9307;LAMA3_8980;JUN_8938;HSPB1_8847;HMGCR_8810;GLUL_32832;GADD45A_8678;FOXO3_8662;FOS_8657;FN1_8655;ESR1_33192;ERBB3_8571;EGR1_8533;DUSP6_8506;CTSC_32456;CPB2_8369;CD36_8243;BHLHE40_8141;AHSG_8003 34.6554431538462 26.149250000000002 1.28141E-12 29.9847069842838 45.85254676861876 30.596555152433165 24.598168115384667 20.741500000000002 1.28141E-12 22.773703090161284 32.76705772404546 24.29805001163329 56.47399192307698 41.2117 1.28142E-12 42.83374842969083 72.02077753538791 40.05560802271628 24.5 96.01005 0.348134;45.1539;29.766;77.4407;12.4414;18.7324;56.8931;0.520151;2.46923;16.4324;89.1011;1.63089;26.4669;102.919;13.1992;1.28141E-12;59.5777;23.3972;60.9984;0.750017;62.3934;56.2386;25.8316;48.1296;57.8085;12.402 0.118102;28.132;23.347;58.7732;8.48981;11.6701;45.1162;0.160202;0.871501;10.5224;60.3265;0.663137;21.0456;89.5012;5.6804;1.28141E-12;31.0499;18.3088;41.6036;0.186019;39.0875;38.2681;20.4374;37.5433;38.3491;10.3013 1.15962;61.5341;40.8256;89.8047;79.2355;41.5978;81.5688;2.88499;10.4175;39.929;106.138;7.6286;35.4303;115.437;32.7581;1.28142E-12;105.243;31.9156;113.972;4.70178;133.304;102.888;34.8042;69.1421;110.58;15.4235 5 21 5 24825;25106;81819;29496;29184 TF_10003;RGN_9699;PAX8_9432;ERBB3_8571;CD36_8243 57.72314 56.8931 12.74970853325678 42.23366 41.6036 11.215153672063524 83.20434 81.5688 20.372987879616463 45.1539;77.4407;56.8931;60.9984;48.1296 28.132;58.7732;45.1162;41.6036;37.5433 61.5341;89.8047;81.5688;113.972;69.1421 21 79426;24794;29441;25513;25493;307582;24516;24471;25675;24957;25112;294515;314322;25661;24890;24330;116663;25423;113936;79431;25373 ZFP36_10204;SERPINA3C_32925;POR_9531;PIK3R1_32562;NFKBIA_9307;LAMA3_8980;JUN_8938;HSPB1_8847;HMGCR_8810;GLUL_32832;GADD45A_8678;FOXO3_8662;FOS_8657;FN1_8655;ESR1_33192;EGR1_8533;DUSP6_8506;CTSC_32456;CPB2_8369;BHLHE40_8141;AHSG_8003 29.163134380952435 18.7324 30.44074431980824 20.399241476190536 11.6701 22.95388482371651 50.109623333333396 35.4303 44.60092436981734 0.348134;29.766;12.4414;18.7324;0.520151;2.46923;16.4324;89.1011;1.63089;26.4669;102.919;13.1992;1.28141E-12;59.5777;23.3972;0.750017;62.3934;56.2386;25.8316;57.8085;12.402 0.118102;23.347;8.48981;11.6701;0.160202;0.871501;10.5224;60.3265;0.663137;21.0456;89.5012;5.6804;1.28141E-12;31.0499;18.3088;0.186019;39.0875;38.2681;20.4374;38.3491;10.3013 1.15962;40.8256;79.2355;41.5978;2.88499;10.4175;39.929;106.138;7.6286;35.4303;115.437;32.7581;1.28142E-12;105.243;31.9156;4.70178;133.304;102.888;34.8042;110.58;15.4235 0 Exp 2,8(0.31);Exp 4,4(0.16);Hill,3(0.12);Linear,3(0.12);Poly 2,7(0.27);Power,1(0.04) 1.941147568764979 52.13779902458191 1.5630855560302734 4.21828556060791 0.6108104769398013 1.806852400302887 23.12969285370925 46.18119345398316 15.844238475043841 33.35209775572548 40.009229099873004 72.93875474628092 DOWN 0.19230769230769232 0.8076923076923077 0.0 GO:0060135 4 maternal process involved in female pregnancy 17 18 3 3 3 3 3 3 159 15 2370 0.97609 0.10206 0.10206 16.67 29540;24890;29184 hsd17b7;esr1;cd36 HSD17B7_8834;ESR1_33192;CD36_8243 24.168098 23.3972 0.977494 23.585503765101397 34.72693181654756 23.94716244371734 18.724927333333337 18.3088 0.322682 18.613797907564198 27.00003457142858 18.877736883434014 35.517473333333335 31.9156 5.49472 31.97619995947195 50.565601184704924 32.70448349778193 0.0 0.977494 0.5 12.187347 0.977494;23.3972;48.1296 0.322682;18.3088;37.5433 5.49472;31.9156;69.1421 1 2 1 29184 CD36_8243 48.1296 48.1296 37.5433 37.5433 69.1421 69.1421 48.1296 37.5433 69.1421 2 29540;24890 HSD17B7_8834;ESR1_33192 12.187347 12.187347 15.853126144808728 9.315741000000001 9.315741000000001 12.718106005021424 18.70516 18.70516 18.68238341291603 0.977494;23.3972 0.322682;18.3088 5.49472;31.9156 0 Exp 2,2(0.67);Exp 4,1(0.34) 2.2390146114806035 6.8321651220321655 1.7248681783676147 2.6703107357025146 0.4925129528819037 2.436986207962036 -2.5214120175982764 50.85760801759828 -2.3385678825106915 39.788422549177355 -0.6670032690210235 71.70194993568768 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0032880 5 regulation of protein localization 255 275 24 23 17 21 15 15 147 260 2125 0.30907 0.77962 0.60127 5.45 362895;293615;25513;25591;100359982;24539;63868;25675;113965;290556;24957;25661;361969;65210;29184 stac3;sirt3;pik3r1;parp1;mpc2;lpl;hspd1;hmgcr;hadh;gnl3;glul;fn1;fga;cyp2j4;cd36 STAC3_9953;SIRT3_9828;PIK3R1_32562;PARP1_9425;MPC2_33219;LPL_32544;HSPD1_8849;HMGCR_8810;HADH_8776;GNL3_8735;GLUL_32832;FN1_8655;FGA_8632;CYP2J4_32580;CD36_8243 38.52049133333333 33.3125 1.63089 25.080508961447354 40.19903792680085 21.305994700782065 26.268228466666663 23.9469 0.56209 16.01836453720255 27.603271124096672 13.43473502397478 73.268018 46.9856 7.6286 62.801750285626156 70.89928934349435 48.91002267582541 12.5 68.7217 63.2393;2.38018;18.7324;26.9741;46.8463;74.2041;42.2579;1.63089;33.3125;87.6357;26.4669;59.5777;28.5803;17.8395;48.1296 42.7031;0.56209;11.6701;21.799;35.8494;49.8682;23.9469;0.663137;25.7336;54.41;21.0456;31.0499;22.529;14.6501;37.5433 121.52;8.82917;41.5978;35.2797;69.127;155.425;102.383;7.6286;46.9856;238.963;35.4303;105.243;38.8511;22.6149;69.1421 9 6 9 293615;25591;100359982;24539;63868;113965;290556;65210;29184 SIRT3_9828;PARP1_9425;MPC2_33219;LPL_32544;HSPD1_8849;HADH_8776;GNL3_8735;CYP2J4_32580;CD36_8243 42.17554222222222 42.2579 26.54072152385923 29.373621111111106 25.7336 16.964992398414488 83.19438555555556 69.127 73.3583980341217 2.38018;26.9741;46.8463;74.2041;42.2579;33.3125;87.6357;17.8395;48.1296 0.56209;21.799;35.8494;49.8682;23.9469;25.7336;54.41;14.6501;37.5433 8.82917;35.2797;69.127;155.425;102.383;46.9856;238.963;22.6149;69.1421 6 362895;25513;25675;24957;25661;361969 STAC3_9953;PIK3R1_32562;HMGCR_8810;GLUL_32832;FN1_8655;FGA_8632 33.037915 27.523600000000002 23.96072366248044 21.610139500000002 21.787300000000002 14.647637143334801 58.37846666666667 40.224450000000004 44.60541191154573 63.2393;18.7324;1.63089;26.4669;59.5777;28.5803 42.7031;11.6701;0.663137;21.0456;31.0499;22.529 121.52;41.5978;7.6286;35.4303;105.243;38.8511 0 Exp 2,5(0.34);Exp 3,1(0.07);Exp 4,1(0.07);Hill,1(0.07);Linear,5(0.34);Poly 2,1(0.07);Power,1(0.07) 2.0082560061263304 31.226142406463623 1.5209722518920898 3.8079800605773926 0.6325709798594527 1.9017701148986816 25.82800257978004 51.21298008688661 18.161817546087516 34.37463938724582 41.48594729206283 105.05008870793719 UP 0.6 0.4 0.0 GO:0007600 5 sensory perception 62 65 2 2 2 2 2 2 160 63 2322 0.20585 0.92695 0.43533 3.08 65030;29184 ephx2;cd36 EPHX2_33282;CD36_8243 43.42945 43.42945 38.7293 6.6470158751879005 44.46433358925144 6.4838917293857135 33.3765 33.3765 29.2097 5.892745071696241 34.29395006854949 5.748131454954499 63.1767 63.1767 57.2113 8.436349584980546 64.49016756238002 8.229313473501538 38.7293;48.1296 29.2097;37.5433 57.2113;69.1421 2 0 2 65030;29184 EPHX2_33282;CD36_8243 43.42945 43.42945 6.6470158751879005 33.3765 33.3765 5.892745071696241 63.1767 63.1767 8.436349584980546 38.7293;48.1296 29.2097;37.5433 57.2113;69.1421 0 0 Exp 2,1(0.5);Linear,1(0.5) 3.521101395537822 7.313274145126343 2.6703107357025146 4.642963409423828 1.3948760825141147 3.6566370725631714 34.217156 52.641744 25.209572 41.543428 51.484516 74.868884 UP 1.0 0.0 0.0 GO:0042108 7 positive regulation of cytokine biosynthetic process 31 34 3 3 2 3 2 2 160 32 2353 0.63122 0.64759 1.0 5.88 24471;24330 hspb1;egr1 HSPB1_8847;EGR1_8533 44.9255585 44.9255585 0.750017 62.4736499144755 46.90307009579527 62.41102330048303 30.256259500000002 30.256259500000002 0.186019 42.52574193892072 31.602349378198838 42.4831120745091 55.41989 55.41989 4.70178 71.7262390199305 57.690278709141694 71.65433716226117 0.5 44.9255585 89.1011;0.750017 60.3265;0.186019 106.138;4.70178 0 2 0 2 24471;24330 HSPB1_8847;EGR1_8533 44.9255585 44.9255585 62.4736499144755 30.256259500000002 30.256259500000002 42.52574193892072 55.41989 55.41989 71.7262390199305 89.1011;0.750017 60.3265;0.186019 106.138;4.70178 0 Hill,1(0.5);Poly 2,1(0.5) 2.675774714900579 5.915603160858154 1.6973176002502441 4.21828556060791 1.7825935399229251 2.957801580429077 -41.65850283999999 131.50961984 -28.681411879999988 89.19393088 -43.98760559999999 154.82738559999999 DOWN 0.0 1.0 0.0 GO:0071871 6 response to epinephrine 8 9 3 3 3 2 2 2 160 7 2378 0.98404 0.10782 0.10782 22.22 83516;24651 ppargc1a;pklr PPARGC1A_33189;PKLR_9489 32.752849999999995 32.752849999999995 23.0963 13.656423975733913 33.77742533814247 13.579337485972593 21.88065 21.88065 17.4625 6.2482076505986885 22.349422753231142 6.21293835931567 57.3374 57.3374 32.9443 34.49705284832315 59.92554676886085 34.30232714883452 0.0 23.0963 0.0 23.0963 42.4094;23.0963 26.2988;17.4625 81.7305;32.9443 0 2 0 2 83516;24651 PPARGC1A_33189;PKLR_9489 32.752849999999995 32.752849999999995 13.656423975733913 21.88065 21.88065 6.2482076505986885 57.3374 57.3374 34.49705284832315 42.4094;23.0963 26.2988;17.4625 81.7305;32.9443 0 Exp 2,2(1) 2.177131926329393 4.454392075538635 1.7576230764389038 2.6967689990997314 0.6640764504371681 2.2271960377693176 13.826011999999999 51.67968799999999 13.221076 30.540224 9.526923999999994 105.14787600000001 DOWN 0.0 1.0 0.0 GO:0009749 8 response to glucose 89 93 16 15 12 14 11 11 151 82 2303 0.98677 0.031392 0.046321 11.83 29573;25351;83516;24651;24957;294515;25661;24330;25428;113936;367313 slc37a4;slc2a2;ppargc1a;pklr;glul;foxo3;fn1;egr1;cyp7a1;cpb2;col6a3 SLC37A4_9871;SLC2A2_9863;PPARGC1A_33189;PKLR_9489;GLUL_32832;FOXO3_8662;FN1_8655;EGR1_8533;CYP7A1_8430;CPB2_8369;COL6A3_33029 29.968772454545455 26.4669 0.750017 20.064467093703588 38.12828095385267 21.734703759592648 19.257081090909093 21.0456 0.186019 12.861169638071635 23.702145081765636 13.220961722371285 51.99682545454545 35.4303 4.70178 36.2066624866243 66.6842671954497 41.21785632953169 3.5 24.46395 8.5 50.99355 39.7166;29.7555;42.4094;23.0963;26.4669;13.1992;59.5777;0.750017;5.72128;25.8316;63.132 22.6911;23.3399;26.2988;17.4625;21.0456;5.6804;31.0499;0.186019;0.985273;20.4374;42.651 60.0334;40.808;81.7305;32.9443;35.4303;32.7581;105.243;4.70178;22.3625;34.8042;121.149 0 11 0 11 29573;25351;83516;24651;24957;294515;25661;24330;25428;113936;367313 SLC37A4_9871;SLC2A2_9863;PPARGC1A_33189;PKLR_9489;GLUL_32832;FOXO3_8662;FN1_8655;EGR1_8533;CYP7A1_8430;CPB2_8369;COL6A3_33029 29.968772454545455 26.4669 20.064467093703588 19.257081090909093 21.0456 12.861169638071635 51.99682545454545 35.4303 36.2066624866243 39.7166;29.7555;42.4094;23.0963;26.4669;13.1992;59.5777;0.750017;5.72128;25.8316;63.132 22.6911;23.3399;26.2988;17.4625;21.0456;5.6804;31.0499;0.186019;0.985273;20.4374;42.651 60.0334;40.808;81.7305;32.9443;35.4303;32.7581;105.243;4.70178;22.3625;34.8042;121.149 0 Exp 2,3(0.28);Exp 4,1(0.1);Hill,2(0.19);Linear,3(0.28);Poly 2,1(0.1);Power,1(0.1) 2.2253862013759735 26.250009179115295 1.5630855560302734 4.560328960418701 1.0453888327969738 1.893584966659546 18.111430129294078 41.82611477979682 11.65661553209042 26.85754664972776 30.60005525607534 73.39359565301558 DOWN 0.0 1.0 0.0 GO:0019752 6 carboxylic acid metabolic process 287 320 83 83 58 75 51 51 111 269 2116 1.0 4.013E-11 4.013E-11 15.94 286954;29573;65192;29500;246074;25106;501907;83516;29441;24651;100359982;24552;24539;54404;50693;306251;364070;24443;171155;113965;85255;81869;29328;24957;295143;65030;25315;171142;291075;29740;25428;65210;24894;25146;83842;497840;81718;29184;25698;25284;65183;50681;192272;170570;50559;24158;25287;170465;312382;25303;296925 ugt2b1;slc37a4;slc27a2;slc10a2;scd;rgn;rgd1559459;ppargc1a;por;pklr;mpc2;me1;lpl;itih4;itih3;itih1;iars2;hdc;hadhb;hadh;hacl1;gstm7;gpx4;glul;etfdh;ephx2;ephx1;ehhadh;eci2;eci1;cyp7a1;cyp2j4;cyp2a1;cyp17a1;crot;cps1;cdo1;cd36;ass1;amacr;aldh3a2;acox1;acot2;acot12;acot1;acadm;acadl;acaa2;abcg2;abcc2;aass UGT2B10_33303,UGT2B1_33224;SLC37A4_9871;SLC27A2_9860;SLC10A2_9833;SCD1_9787;RGN_9699;RGD1559459_9690;PPARGC1A_33189;POR_9531;PKLR_9489;MPC2_33219;ME1_9215;LPL_32544;ITIH4_32725;ITIH3_32422;ITIH1_33132;IARS2_8858;HDC_8788;HADHB_8777;HADH_8776;HACL1_8775;GSTM7_8761;GPX4_32827;GLUL_32832;ETFDH_8575;EPHX2_33282;EPHX1_8567;EHHADH_8534;ECI2_8521;ECI1_8520;CYP7A1_8430;CYP2J4_32580;CYP2A1_32717;CYP17A1_32365;CROT_8384;CPS1_32421;CDO1_8275;CD36_8243;ASS1_33159;AMACR_8038;ALDH3A2_8024;ACOX1_7973;ACOT2_7969;ACOT12_32718;ACOT1_7968;ACADM_7957;ACADL_32776;ACAA2_7955;ABCG2_32656;ABCC2_32541;AASS_7936 33.311451764705886 27.4644 2.52378E-13 23.795708125329714 34.741485012175026 23.618566712547437 23.606691627450992 21.7498 2.52378E-13 15.308549215768236 24.349162288299016 14.55657483499366 56.41190901960786 37.6534 2.52379E-13 61.91367968278874 57.98398452916485 57.171069165774455 15.0 18.1231 31.0 33.4878 47.47345;39.7166;7.62189;56.585;105.46;77.4407;2.52378E-13;42.4094;12.4414;23.0963;46.8463;80.7944;74.2041;57.1163;27.1247;98.1741;24.7304;24.5745;31.8029;33.3125;17.6275;42.3152;45.9204;26.4669;18.1231;38.7293;12.4747;8.62809;10.6467;11.9473;5.72128;17.8395;55.3937;49.6922;7.4229;31.9826;22.9638;48.1296;26.8037;2.03774;43.1079;23.1906;8.54905;30.3423;31.2018;11.7137;33.4878;26.5872;5.21654;46.2316;27.4644 34.82915;22.6911;5.49916;35.2796;63.7532;58.7732;2.52378E-13;26.2988;8.48981;17.4625;35.8494;59.856;49.8682;39.6402;21.5108;42.9071;19.8021;21.0619;25.5756;25.7336;11.195;31.4035;34.2198;21.0456;14.869;29.2097;7.00435;7.31865;8.92359;7.15307;0.985273;14.6501;38.7444;35.6654;5.75707;24.4836;18.5144;37.5433;20.9825;1.165;31.8774;16.2815;7.19676;24.0157;26.858;8.36151;26.6039;21.3695;2.73368;31.1788;21.7498 76.47475;60.0334;13.3925;116.8;422.699;89.8047;2.52379E-13;81.7305;79.2355;32.9443;69.127;94.0621;155.425;101.869;36.4819;104.278;32.7087;29.28;42.1484;46.9856;37.6534;64.5991;70.4292;35.4303;23.0103;57.2113;23.684;10.3909;13.0581;19.001;22.3625;22.6149;96.8569;81.6409;10.316;45.5891;30.0179;69.1421;36.7081;3.73641;66.3058;33.4539;10.4125;41.1025;37.2719;18.9642;45.3228;35.0407;11.386;81.7848;37.0295 36 16 35 286954;65192;246074;25106;100359982;24539;364070;24443;171155;113965;85255;81869;29328;295143;65030;25315;171142;291075;29740;65210;24894;25146;83842;29184;25284;65183;50681;192272;170570;50559;24158;25287;170465;312382;296925 UGT2B10_33303,UGT2B1_33224;SLC27A2_9860;SCD1_9787;RGN_9699;MPC2_33219;LPL_32544;IARS2_8858;HDC_8788;HADHB_8777;HADH_8776;HACL1_8775;GSTM7_8761;GPX4_32827;ETFDH_8575;EPHX2_33282;EPHX1_8567;EHHADH_8534;ECI2_8521;ECI1_8520;CYP2J4_32580;CYP2A1_32717;CYP17A1_32365;CROT_8384;CD36_8243;AMACR_8038;ALDH3A2_8024;ACOX1_7973;ACOT2_7969;ACOT12_32718;ACOT1_7968;ACADM_7957;ACADL_32776;ACAA2_7955;ABCG2_32656;AASS_7936 31.464456 27.4644 22.806373704712875 23.21757685714286 21.7498 15.51773113390761 54.790856000000005 37.2719 71.41443959567462 47.47345;7.62189;105.46;77.4407;46.8463;74.2041;24.7304;24.5745;31.8029;33.3125;17.6275;42.3152;45.9204;18.1231;38.7293;12.4747;8.62809;10.6467;11.9473;17.8395;55.3937;49.6922;7.4229;48.1296;2.03774;43.1079;23.1906;8.54905;30.3423;31.2018;11.7137;33.4878;26.5872;5.21654;27.4644 34.82915;5.49916;63.7532;58.7732;35.8494;49.8682;19.8021;21.0619;25.5756;25.7336;11.195;31.4035;34.2198;14.869;29.2097;7.00435;7.31865;8.92359;7.15307;14.6501;38.7444;35.6654;5.75707;37.5433;1.165;31.8774;16.2815;7.19676;24.0157;26.858;8.36151;26.6039;21.3695;2.73368;21.7498 76.47475;13.3925;422.699;89.8047;69.127;155.425;32.7087;29.28;42.1484;46.9856;37.6534;64.5991;70.4292;23.0103;57.2113;23.684;10.3909;13.0581;19.001;22.6149;96.8569;81.6409;10.316;69.1421;3.73641;66.3058;33.4539;10.4125;41.1025;37.2719;18.9642;45.3228;35.0407;11.386;37.0295 16 29573;29500;501907;83516;29441;24651;24552;54404;50693;306251;24957;25428;497840;81718;25698;25303 SLC37A4_9871;SLC10A2_9833;RGD1559459_9690;PPARGC1A_33189;POR_9531;PKLR_9489;ME1_9215;ITIH4_32725;ITIH3_32422;ITIH1_33132;GLUL_32832;CYP7A1_8430;CPS1_32421;CDO1_8275;ASS1_33159;ABCC2_32541 37.35175500000001 29.55365 26.13651279358436 24.457880187500017 22.100949999999997 15.304667998104229 59.957962500000015 52.81125 34.61335677004614 39.7166;56.585;2.52378E-13;42.4094;12.4414;23.0963;80.7944;57.1163;27.1247;98.1741;26.4669;5.72128;31.9826;22.9638;26.8037;46.2316 22.6911;35.2796;2.52378E-13;26.2988;8.48981;17.4625;59.856;39.6402;21.5108;42.9071;21.0456;0.985273;24.4836;18.5144;20.9825;31.1788 60.0334;116.8;2.52379E-13;81.7305;79.2355;32.9443;94.0621;101.869;36.4819;104.278;35.4303;22.3625;45.5891;30.0179;36.7081;81.7848 0 Exp 2,20(0.39);Exp 3,1(0.02);Exp 4,2(0.04);Hill,5(0.1);Linear,16(0.31);Poly 2,7(0.14);Power,1(0.02) 2.7052310611790675 524.0913391113281 1.5074360370635986 344.14306640625 47.50981060246011 1.901495099067688 26.780603154750313 39.84230037466144 19.405185337339223 27.808197917562754 39.419396472222886 73.4044215669928 UP 0.6862745098039216 0.3137254901960784 0.0 GO:0031399 7 regulation of protein modification process 444 469 34 34 27 31 24 24 138 445 1940 0.13085 0.91038 0.24965 5.12 246273;24825;293615;25106;192280;83516;25513;24516;24471;25675;290556;29455;299626;25112;25661;361969;24890;29496;24330;116663;140942;114851;29184;25373 trib3;tf;sirt3;rgn;ppp1r3b;ppargc1a;pik3r1;jun;hspb1;hmgcr;gnl3;gdf15;gadd45b;gadd45a;fn1;fga;esr1;erbb3;egr1;dusp6;ddit4;cdkn1a;cd36;ahsg TRIB3_10079;TF_10003;SIRT3_9828;RGN_9699;PPP1R3B_9545;PPARGC1A_33189;PIK3R1_32562;JUN_8938;HSPB1_8847;HMGCR_8810;GNL3_8735;GDF15_33113;GADD45B_8679;GADD45A_8678;FN1_8655;FGA_8632;ESR1_33192;ERBB3_8571;EGR1_8533;DUSP6_8506;DDIT4_8450;CDKN1A_8271;CD36_8243;AHSG_8003 51.232381541666676 46.64175 0.750017 37.14612408284219 51.05143089898874 35.01466022403258 35.25661233333334 29.59095 0.186019 27.359480229162813 36.38893872506177 27.81771032502636 83.36816458333334 75.4363 4.70178 65.31716762779676 76.31483282839145 49.84168924733607 22.5 107.21549999999999 108.064;45.1539;2.38018;77.4407;36.1411;42.4094;18.7324;16.4324;89.1011;1.63089;87.6357;105.149;106.367;102.919;59.5777;28.5803;23.3972;60.9984;0.750017;62.3934;87.5421;6.24967;48.1296;12.402 83.8836;28.132;0.56209;58.7732;27.0588;26.2988;11.6701;10.5224;60.3265;0.663137;54.41;85.3487;52.7132;89.5012;31.0499;22.529;18.3088;41.6036;0.186019;39.0875;53.2453;2.44025;37.5433;10.3013 143.428;61.5341;8.82917;89.8047;53.6244;81.7305;41.5978;39.929;106.138;7.6286;238.963;125.652;109.434;115.437;105.243;38.8511;31.9156;113.972;4.70178;133.304;245.492;19.0606;69.1421;15.4235 7 17 7 24825;293615;25106;290556;299626;29496;29184 TF_10003;SIRT3_9828;RGN_9699;GNL3_8735;GADD45B_8679;ERBB3_8571;CD36_8243 61.15792571428572 60.9984 33.888977109142175 39.10534142857143 41.6036 20.08693095764045 98.8112957142857 89.8047 71.21907659240229 45.1539;2.38018;77.4407;87.6357;106.367;60.9984;48.1296 28.132;0.56209;58.7732;54.41;52.7132;41.6036;37.5433 61.5341;8.82917;89.8047;238.963;109.434;113.972;69.1421 17 246273;192280;83516;25513;24516;24471;25675;29455;25112;25661;361969;24890;24330;116663;140942;114851;25373 TRIB3_10079;PPP1R3B_9545;PPARGC1A_33189;PIK3R1_32562;JUN_8938;HSPB1_8847;HMGCR_8810;GDF15_33113;GADD45A_8678;FN1_8655;FGA_8632;ESR1_33192;EGR1_8533;DUSP6_8506;DDIT4_8450;CDKN1A_8271;AHSG_8003 47.14539276470588 36.1411 38.626289274873066 33.67184152941177 26.2988 30.25842174873664 77.00922823529412 53.6244 63.902199867274156 108.064;36.1411;42.4094;18.7324;16.4324;89.1011;1.63089;105.149;102.919;59.5777;28.5803;23.3972;0.750017;62.3934;87.5421;6.24967;12.402 83.8836;27.0588;26.2988;11.6701;10.5224;60.3265;0.663137;85.3487;89.5012;31.0499;22.529;18.3088;0.186019;39.0875;53.2453;2.44025;10.3013 143.428;53.6244;81.7305;41.5978;39.929;106.138;7.6286;125.652;115.437;105.243;38.8511;31.9156;4.70178;133.304;245.492;19.0606;15.4235 0 Exp 2,7(0.3);Exp 4,2(0.09);Hill,2(0.09);Linear,3(0.13);Poly 2,8(0.34);Power,2(0.09) 1.8718496558571127 46.67544865608215 1.5209722518920898 4.21828556060791 0.6514059329913215 1.7086020708084106 36.37083672057139 66.09392636276195 24.310540522428468 46.202684144238205 57.23585500178352 109.50047416488316 DOWN 0.2916666666666667 0.7083333333333334 0.0 GO:0010646 5 regulation of cell communication 678 722 60 59 48 54 44 44 118 678 1707 0.40306 0.66529 0.78723 6.09 308843;246273;24825;293615;297784;25106;83516;29441;85253;25513;81819;25591;25493;100359982;24539;24516;25685;192235;65164;63868;24471;25675;113965;81869;24957;29455;299626;25112;289388;294515;25661;361969;24890;29496;24330;116663;140942;65210;25423;29184;246142;79431;25373;170465 tsku;trib3;tf;sirt3;rrs1;rgn;ppargc1a;por;plg;pik3r1;pax8;parp1;nfkbia;mpc2;lpl;jun;igfbp1;hyou1;htra1;hspd1;hspb1;hmgcr;hadh;gstm7;glul;gdf15;gadd45b;gadd45a;g0s2;foxo3;fn1;fga;esr1;erbb3;egr1;dusp6;ddit4;cyp2j4;ctsc;cd36;bmf;bhlhe40;ahsg;acaa2 TSKU_10094;TRIB3_10079;TF_10003;SIRT3_9828;RRS1_9755;RGN_9699;PPARGC1A_33189;POR_9531;PLG_9501;PIK3R1_32562;PAX8_9432;PARP1_9425;NFKBIA_9307;MPC2_33219;LPL_32544;JUN_8938;IGFBP1_32306;HYOU1_8857;HTRA1_8856;HSPD1_8849;HSPB1_8847;HMGCR_8810;HADH_8776;GSTM7_8761;GLUL_32832;GDF15_33113;GADD45B_8679;GADD45A_8678;G0S2_32729;FOXO3_8662;FN1_8655;FGA_8632;ESR1_33192;ERBB3_8571;EGR1_8533;DUSP6_8506;DDIT4_8450;CYP2J4_32580;CTSC_32456;CD36_8243;BMF_8152;BHLHE40_8141;AHSG_8003;ACAA2_7955 46.12787950000001 43.78165 0.520151 31.22414341695707 50.11539795583591 29.791638468128173 32.4653915 30.21715 0.160202 22.980090713258708 36.10343964536621 23.097347919287518 75.16594454545455 71.39750000000001 2.88499 50.1320491460884 79.02645660941614 44.622947908474295 35.5 75.8224 1.38416;108.064;45.1539;2.38018;60.39;77.4407;42.4094;12.4414;70.7857;18.7324;56.8931;26.9741;0.520151;46.8463;74.2041;16.4324;49.0259;40.1982;33.1323;42.2579;89.1011;1.63089;33.3125;42.3152;26.4669;105.149;106.367;102.919;46.3784;13.1992;59.5777;28.5803;23.3972;60.9984;0.750017;62.3934;87.5421;17.8395;56.2386;48.1296;94.8767;57.8085;12.402;26.5872 0.540568;83.8836;28.132;0.56209;43.109;58.7732;26.2988;8.48981;46.2356;11.6701;45.1162;21.799;0.160202;35.8494;49.8682;10.5224;32.6883;29.3844;25.6145;23.9469;60.3265;0.663137;25.7336;31.4035;21.0456;85.3487;52.7132;89.5012;33.7914;5.6804;31.0499;22.529;18.3088;41.6036;0.186019;39.0875;53.2453;14.6501;38.2681;37.5433;73.1342;38.3491;10.3013;21.3695 4.10872;143.428;61.5341;8.82917;104.942;89.8047;81.7305;79.2355;150.579;41.5978;81.5688;35.2797;2.88499;69.127;155.425;39.929;89.1623;62.3571;46.6629;102.383;106.138;7.6286;46.9856;64.5991;35.4303;125.652;109.434;115.437;73.6529;32.7581;105.243;38.8511;31.9156;113.972;4.70178;133.304;245.492;22.6149;102.888;69.1421;109.848;110.58;15.4235;35.0407 18 26 18 24825;293615;297784;25106;81819;25591;100359982;24539;63868;113965;81869;299626;289388;29496;65210;29184;246142;170465 TF_10003;SIRT3_9828;RRS1_9755;RGN_9699;PAX8_9432;PARP1_9425;MPC2_33219;LPL_32544;HSPD1_8849;HADH_8776;GSTM7_8761;GADD45B_8679;G0S2_32729;ERBB3_8571;CYP2J4_32580;CD36_8243;BMF_8152;ACAA2_7955 50.519154444444446 46.61235 26.15494308735028 35.50546611111111 34.82040000000001 17.14684341111049 75.23237611111111 71.39750000000001 37.36698145027053 45.1539;2.38018;60.39;77.4407;56.8931;26.9741;46.8463;74.2041;42.2579;33.3125;42.3152;106.367;46.3784;60.9984;17.8395;48.1296;94.8767;26.5872 28.132;0.56209;43.109;58.7732;45.1162;21.799;35.8494;49.8682;23.9469;25.7336;31.4035;52.7132;33.7914;41.6036;14.6501;37.5433;73.1342;21.3695 61.5341;8.82917;104.942;89.8047;81.5688;35.2797;69.127;155.425;102.383;46.9856;64.5991;109.434;73.6529;113.972;22.6149;69.1421;109.848;35.0407 26 308843;246273;83516;29441;85253;25513;25493;24516;25685;192235;65164;24471;25675;24957;29455;25112;294515;25661;361969;24890;24330;116663;140942;25423;79431;25373 TSKU_10094;TRIB3_10079;PPARGC1A_33189;POR_9531;PLG_9501;PIK3R1_32562;NFKBIA_9307;JUN_8938;IGFBP1_32306;HYOU1_8857;HTRA1_8856;HSPB1_8847;HMGCR_8810;GLUL_32832;GDF15_33113;GADD45A_8678;FOXO3_8662;FN1_8655;FGA_8632;ESR1_33192;EGR1_8533;DUSP6_8506;DDIT4_8450;CTSC_32456;BHLHE40_8141;AHSG_8003 43.087766076923074 36.66525 34.47082825532341 30.36072446153846 25.95665 26.40292956494995 75.11995346153846 70.7963 58.07976395984425 1.38416;108.064;42.4094;12.4414;70.7857;18.7324;0.520151;16.4324;49.0259;40.1982;33.1323;89.1011;1.63089;26.4669;105.149;102.919;13.1992;59.5777;28.5803;23.3972;0.750017;62.3934;87.5421;56.2386;57.8085;12.402 0.540568;83.8836;26.2988;8.48981;46.2356;11.6701;0.160202;10.5224;32.6883;29.3844;25.6145;60.3265;0.663137;21.0456;85.3487;89.5012;5.6804;31.0499;22.529;18.3088;0.186019;39.0875;53.2453;38.2681;38.3491;10.3013 4.10872;143.428;81.7305;79.2355;150.579;41.5978;2.88499;39.929;89.1623;62.3571;46.6629;106.138;7.6286;35.4303;125.652;115.437;32.7581;105.243;38.8511;31.9156;4.70178;133.304;245.492;102.888;110.58;15.4235 0 Exp 2,15(0.35);Exp 3,1(0.03);Exp 4,3(0.07);Hill,3(0.07);Linear,10(0.23);Poly 2,10(0.23);Power,2(0.05) 1.9803731859121423 90.74236118793488 1.5209722518920898 4.21828556060791 0.6755097263679909 1.7939516305923462 36.90173470436305 55.35402429563695 25.675208611515853 39.255574388484135 60.35287063186841 89.97901845904069 CONFLICT 0.4090909090909091 0.5909090909090909 0.0 GO:1901360 4 organic cyclic compound metabolic process 507 567 87 86 63 74 53 53 109 514 1871 0.99946 0.0010016 0.0016742 9.35 79426;286954;24856;293688;361510;360268;29573;65192;29500;246074;297784;501907;298490;83516;303612;24651;81819;25591;294103;100359982;24516;364070;63868;29540;289456;25675;24443;81869;499914;24384;294515;314322;246186;308441;24890;65030;25315;24330;25428;266682;24894;25146;83842;497840;25028;25284;192272;170570;50559;170465;312382;25303;296925 zfp36;ugt2b1;ttr;tm7sf2;sult2a2;sult1e1;slc37a4;slc27a2;slc10a2;scd;rrs1;rgd1559459;ppcs;ppargc1a;polg2;pklr;pax8;parp1;papss2;mpc2;jun;iars2;hspd1;hsd17b7;hsd17b11;hmgcr;hdc;gstm7;gins1;gc;foxo3;fos;fgl1;exosc5;esr1;ephx2;ephx1;egr1;cyp7a1;cyp3a2;cyp2a1;cyp17a1;crot;cps1;ampd1;amacr;acot2;acot12;acot1;acaa2;abcg2;abcc2;aass ZFP36_10204;UGT2B10_33303,UGT2B1_33224;TTR_10102;TM7SF2_10031;SULT2A2_33196;SULT1E1_32446;SLC37A4_9871;SLC27A2_9860;SLC10A2_9833;SCD1_9787;RRS1_9755;RGD1559459_9690;PPCS_9540;PPARGC1A_33189;POLG2_9521;PKLR_9489;PAX8_9432;PARP1_9425;PAPSS2_33237;MPC2_33219;JUN_8938;IARS2_8858;HSPD1_8849;HSD17B7_8834;HSD17B11_8832;HMGCR_8810;HDC_8788;GSTM7_8761;GINS1_8707;GC_32893;FOXO3_8662;FOS_8657;FGL1_8640;EXOSC5_32543;ESR1_33192;EPHX2_33282;EPHX1_8567;EGR1_8533;CYP7A1_8430;CYP3A2_32374;CYP2A1_32717;CYP17A1_32365;CROT_8384;CPS1_32421;AMPD1_32743;AMACR_8038;ACOT2_7969;ACOT12_32718;ACOT1_7968;ACAA2_7955;ABCG2_32656;ABCC2_32541;AASS_7936 31.88452424528305 30.3423 2.52378E-13 23.15192267992379 33.40066222977528 21.508991383118556 22.370319679245313 22.6911 2.52378E-13 15.802823912739026 23.623022586937992 14.983843878048981 58.66131660377363 39.929 2.52379E-13 65.10448547386657 58.98227844186401 58.57958853486329 27.5 31.5922 0.348134;47.47345;46.6406;82.3097;54.1932;50.1846;39.7166;7.62189;56.585;105.46;60.39;2.52378E-13;20.3353;42.4094;63.7758;23.0963;56.8931;26.9741;34.4443;46.8463;16.4324;24.7304;42.2579;0.977494;22.4334;1.63089;24.5745;42.3152;58.9165;42.356;13.1992;1.28141E-12;15.4757;41.9329;23.3972;38.7293;12.4747;0.750017;5.72128;12.8505;55.3937;49.6922;7.4229;31.9826;60.9045;2.03774;8.54905;30.3423;31.2018;26.5872;5.21654;46.2316;27.4644 0.118102;34.82915;28.5876;51.1696;35.5514;36.5009;22.6911;5.49916;35.2796;63.7532;43.109;2.52378E-13;16.7643;26.2988;40.9553;17.4625;45.1162;21.799;25.719;35.8494;10.5224;19.8021;23.9469;0.322682;18.1233;0.663137;21.0619;31.4035;44.7208;26.3722;5.6804;1.28141E-12;10.2138;31.7336;18.3088;29.2097;7.00435;0.186019;0.985273;7.33176;38.7444;35.6654;5.75707;24.4836;50.0633;1.165;7.19676;24.0157;26.858;21.3695;2.73368;31.1788;21.7498 1.15962;76.47475;63.7146;209.842;103.141;80.9788;60.0334;13.3925;116.8;422.699;104.942;2.52379E-13;25.6711;81.7305;132.567;32.9443;81.5688;35.2797;51.1014;69.127;39.929;32.7087;102.383;5.49472;29.2247;7.6286;29.28;64.5991;91.837;78.7583;32.7581;1.28142E-12;30.4106;62.1373;31.9156;57.2113;23.684;4.70178;22.3625;24.0283;96.8569;81.6409;10.316;45.5891;82.6625;3.73641;10.4125;41.1025;37.2719;35.0407;11.386;81.7848;37.0295 32 22 31 286954;24856;360268;65192;246074;297784;298490;81819;25591;100359982;364070;63868;289456;24443;81869;499914;308441;65030;25315;266682;24894;25146;83842;25028;25284;192272;170570;50559;170465;312382;296925 UGT2B10_33303,UGT2B1_33224;TTR_10102;SULT1E1_32446;SLC27A2_9860;SCD1_9787;RRS1_9755;PPCS_9540;PAX8_9432;PARP1_9425;MPC2_33219;IARS2_8858;HSPD1_8849;HSD17B11_8832;HDC_8788;GSTM7_8761;GINS1_8707;EXOSC5_32543;EPHX2_33282;EPHX1_8567;CYP3A2_32374;CYP2A1_32717;CYP17A1_32365;CROT_8384;AMPD1_32743;AMACR_8038;ACOT2_7969;ACOT12_32718;ACOT1_7968;ACAA2_7955;ABCG2_32656;AASS_7936 35.31764419354839 31.2018 22.20127496230922 25.85369129032258 24.0157 15.231199151991447 62.52895032258064 41.1025 73.37588215189514 47.47345;46.6406;50.1846;7.62189;105.46;60.39;20.3353;56.8931;26.9741;46.8463;24.7304;42.2579;22.4334;24.5745;42.3152;58.9165;41.9329;38.7293;12.4747;12.8505;55.3937;49.6922;7.4229;60.9045;2.03774;8.54905;30.3423;31.2018;26.5872;5.21654;27.4644 34.82915;28.5876;36.5009;5.49916;63.7532;43.109;16.7643;45.1162;21.799;35.8494;19.8021;23.9469;18.1233;21.0619;31.4035;44.7208;31.7336;29.2097;7.00435;7.33176;38.7444;35.6654;5.75707;50.0633;1.165;7.19676;24.0157;26.858;21.3695;2.73368;21.7498 76.47475;63.7146;80.9788;13.3925;422.699;104.942;25.6711;81.5688;35.2797;69.127;32.7087;102.383;29.2247;29.28;64.5991;91.837;62.1373;57.2113;23.684;24.0283;96.8569;81.6409;10.316;82.6625;3.73641;10.4125;41.1025;37.2719;35.0407;11.386;37.0295 22 79426;293688;361510;29573;29500;501907;83516;303612;24651;294103;24516;29540;25675;24384;294515;314322;246186;24890;24330;25428;497840;25303 ZFP36_10204;TM7SF2_10031;SULT2A2_33196;SLC37A4_9871;SLC10A2_9833;RGD1559459_9690;PPARGC1A_33189;POLG2_9521;PKLR_9489;PAPSS2_33237;JUN_8938;HSD17B7_8834;HMGCR_8810;GC_32893;FOXO3_8662;FOS_8657;FGL1_8640;ESR1_33192;EGR1_8533;CYP7A1_8430;CPS1_32421;ABCC2_32541 27.046946136363704 23.24675 24.10836417272454 17.461932409090977 17.88565 15.61448928092511 53.21146909090916 36.43665 52.449137406883935 0.348134;82.3097;54.1932;39.7166;56.585;2.52378E-13;42.4094;63.7758;23.0963;34.4443;16.4324;0.977494;1.63089;42.356;13.1992;1.28141E-12;15.4757;23.3972;0.750017;5.72128;31.9826;46.2316 0.118102;51.1696;35.5514;22.6911;35.2796;2.52378E-13;26.2988;40.9553;17.4625;25.719;10.5224;0.322682;0.663137;26.3722;5.6804;1.28141E-12;10.2138;18.3088;0.186019;0.985273;24.4836;31.1788 1.15962;209.842;103.141;60.0334;116.8;2.52379E-13;81.7305;132.567;32.9443;51.1014;39.929;5.49472;7.6286;78.7583;32.7581;1.28142E-12;30.4106;31.9156;4.70178;22.3625;45.5891;81.7848 0 Exp 2,25(0.47);Exp 3,2(0.04);Exp 4,5(0.1);Hill,8(0.15);Linear,9(0.17);Poly 2,5(0.1) 2.4259837827762474 484.46509885787964 1.5074360370635986 344.14306640625 46.54431084469786 1.8959509134292603 25.651408379893923 38.11764011067216 18.11577746215942 26.62486189633122 41.1334504768257 76.18918273072151 CONFLICT 0.5849056603773585 0.41509433962264153 0.0 GO:0019217 7 regulation of fatty acid metabolic process 42 45 8 8 6 8 6 6 156 39 2346 0.97843 0.062517 0.062517 13.33 246273;25106;83516;24360;25428;25287 trib3;rgn;ppargc1a;fabp1;cyp7a1;acadl TRIB3_10079;RGN_9699;PPARGC1A_33189;FABP1_33091;CYP7A1_8430;ACADL_32776 50.16183000000001 38.1286 5.72128 36.5404749440261 56.47892732421468 32.46239248827923 37.16972883333333 26.53875 0.985273 29.334047025370847 41.980301108420136 26.12552534234126 71.59570000000001 64.3281 22.3625 43.16698583867074 79.224076015393 38.37537456238064 1.5 33.6678 3.5 59.92505 108.064;77.4407;42.4094;33.8478;5.72128;33.4878 83.8836;58.7732;26.2988;26.4736;0.985273;26.6039 143.428;89.8047;81.7305;46.9257;22.3625;45.3228 3 3 3 25106;24360;25287 RGN_9699;FABP1_33091;ACADL_32776 48.258766666666666 33.8478 25.27293660822451 37.283566666666665 26.6039 18.610682419603357 60.684400000000004 46.9257 25.23165127711622 77.4407;33.8478;33.4878 58.7732;26.4736;26.6039 89.8047;46.9257;45.3228 3 246273;83516;25428 TRIB3_10079;PPARGC1A_33189;CYP7A1_8430 52.06489333333334 42.4094 51.85006748194387 37.055891 26.2988 42.48316619481701 82.507 81.7305 60.536485170102175 108.064;42.4094;5.72128 83.8836;26.2988;0.985273 143.428;81.7305;22.3625 0 Exp 2,3(0.5);Hill,1(0.17);Poly 2,2(0.34) 2.1230994799389387 13.67754352092743 1.7198865413665771 4.560328960418701 1.1195375881641456 1.8762393593788147 20.9233605998729 79.40029940012712 13.697602714364674 60.641854952302 37.05491758069439 106.13648241930562 CONFLICT 0.5 0.5 0.0 GO:0031100 5 animal organ regeneration 72 80 14 14 9 12 7 7 155 73 2312 0.86754 0.24387 0.34955 8.75 25106;25493;24464;361969;113936;114851;25373 rgn;nfkbia;hp;fga;cpb2;cdkn1a;ahsg RGN_9699;NFKBIA_9307;HP_8823;FGA_8632;CPB2_8369;CDKN1A_8271;AHSG_8003 30.850417285714286 25.8316 0.520151 29.517729261814868 34.9661960108751 29.404572009472584 22.321664571428574 20.4374 0.160202 21.35122777831023 24.6920079792141 21.157669102223533 48.18344142857143 34.8042 2.88499 47.89501935230511 57.92098300056251 50.45869819716671 3.0 25.8316 77.4407;0.520151;64.9285;28.5803;25.8316;6.24967;12.402 58.7732;0.160202;41.6103;22.529;20.4374;2.44025;10.3013 89.8047;2.88499;136.455;38.8511;34.8042;19.0606;15.4235 1 6 1 25106 RGN_9699 77.4407 77.4407 58.7732 58.7732 89.8047 89.8047 77.4407 58.7732 89.8047 6 25493;24464;361969;113936;114851;25373 NFKBIA_9307;HP_8823;FGA_8632;CPB2_8369;CDKN1A_8271;AHSG_8003 23.085370166666667 19.1168 23.217871826158234 16.246408666666667 15.36935 15.395341664914444 41.246565000000004 26.9324 48.46142090356978 0.520151;64.9285;28.5803;25.8316;6.24967;12.402 0.160202;41.6103;22.529;20.4374;2.44025;10.3013 2.88499;136.455;38.8511;34.8042;19.0606;15.4235 0 Exp 2,3(0.43);Exp 4,2(0.29);Linear,1(0.15);Poly 2,1(0.15) 1.8178219606974035 13.266621470451355 1.522104263305664 3.431420087814331 0.6873986699650232 1.6336230039596558 8.98337743536732 52.717457136061256 6.504453682983733 38.138875459873404 12.702314560020376 83.66456829712249 DOWN 0.14285714285714285 0.8571428571428571 0.0 GO:0045820 7 negative regulation of glycolytic process 7 7 2 2 2 2 2 2 160 5 2380 0.99269 0.068343 0.068343 28.57 83516;140942 ppargc1a;ddit4 PPARGC1A_33189;DDIT4_8450 64.97575 64.97575 42.4094 31.91363822325809 54.02952211460855 27.90771389431886 39.77205 39.77205 26.2988 19.054052879243304 33.236599435028246 16.662313853442477 163.61124999999998 163.61124999999998 81.7305 115.79686714728084 123.89346892655367 101.26159278980641 0.0 42.4094 0.0 42.4094 42.4094;87.5421 26.2988;53.2453 81.7305;245.492 0 2 0 2 83516;140942 PPARGC1A_33189;DDIT4_8450 64.97575 64.97575 31.91363822325809 39.77205 39.77205 19.054052879243304 163.61124999999998 163.61124999999998 115.79686714728084 42.4094;87.5421 26.2988;53.2453 81.7305;245.492 0 Exp 2,1(0.5);Linear,1(0.5) 1.711823081699758 3.4248396158218384 1.6672165393829346 1.7576230764389038 0.06392707541586874 1.7124198079109192 20.745704000000003 109.205796 13.364479999999997 66.17962 3.124980000000022 324.0975199999999 DOWN 0.0 1.0 0.0 GO:0071392 6 cellular response to estradiol stimulus 25 26 5 5 5 3 3 3 159 23 2362 0.92111 0.2269 0.2269 11.54 83516;24890;312382 ppargc1a;esr1;abcg2 PPARGC1A_33189;ESR1_33192;ABCG2_32656 23.67438 23.3972 5.21654 18.59797919961198 20.558539509504964 21.099672723629133 15.780426666666665 18.3088 2.73368 11.984290714853902 12.905302531629143 13.54961398154852 41.67736666666667 31.9156 11.386 36.17397180851632 38.86211590216052 39.95240432048916 0.5 14.30687 1.5 32.9033 42.4094;23.3972;5.21654 26.2988;18.3088;2.73368 81.7305;31.9156;11.386 1 2 1 312382 ABCG2_32656 5.21654 5.21654 2.73368 2.73368 11.386 11.386 5.21654 2.73368 11.386 2 83516;24890 PPARGC1A_33189;ESR1_33192 32.9033 32.9033 13.443655545274869 22.303800000000003 22.303800000000003 5.6497831816805 56.82305 56.82305 35.224453594129756 42.4094;23.3972 26.2988;18.3088 81.7305;31.9156 0 Exp 2,2(0.67);Exp 4,1(0.34) 1.8621124489912868 5.702045321464539 1.5074360370635986 2.436986207962036 0.48100439002875567 1.7576230764389038 2.628785337333081 44.719974662666914 2.218925064942109 29.341928268391225 0.7426640385092043 82.61206929482414 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:1905897 6 regulation of response to endoplasmic reticulum stress 26 26 2 2 2 2 2 2 160 24 2361 0.7731 0.50003 0.67957 7.69 25513;192235 pik3r1;hyou1 PIK3R1_32562;HYOU1_8857 29.4653 29.4653 18.7324 15.178612743594194 29.17549644718143 15.173078547926494 20.52725 20.52725 11.6701 12.525901653972866 20.2880943628612 12.521334649607027 51.977450000000005 51.977450000000005 41.5978 14.679041802685852 51.69718469919469 14.673689753001142 0.5 29.4653 18.7324;40.1982 11.6701;29.3844 41.5978;62.3571 0 2 0 2 25513;192235 PIK3R1_32562;HYOU1_8857 29.4653 29.4653 15.178612743594194 20.52725 20.52725 12.525901653972866 51.977450000000005 51.977450000000005 14.679041802685852 18.7324;40.1982 11.6701;29.3844 41.5978;62.3571 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.6628011248238195 3.325671672821045 1.6520916223526 1.6735800504684448 0.015194613237753472 1.6628358364105225 8.428815999999998 50.501784 3.1672360000000026 37.887264 31.633336000000003 72.32156400000001 DOWN 0.0 1.0 0.0 GO:0034097 5 response to cytokine 230 247 21 21 17 19 16 16 146 231 2154 0.59765 0.51007 0.89115 6.48 79426;24648;83516;25493;89783;24516;54404;63868;24471;314322;25661;361969;24330;25146;25698;25303 zfp36;serpina1;ppargc1a;nfkbia;laptm5;jun;itih4;hspd1;hspb1;fos;fn1;fga;egr1;cyp17a1;ass1;abcc2 ZFP36_10204;SERPINA1_9807;PPARGC1A_33189;NFKBIA_9307;LAPTM5_32639;JUN_8938;ITIH4_32725;HSPD1_8849;HSPB1_8847;FOS_8657;FN1_8655;FGA_8632;EGR1_8533;CYP17A1_32365;ASS1_33159;ABCC2_32541 32.14324387500008 33.62715 1.28141E-12 25.771051423152247 39.63400964336353 25.433005967248196 21.265313937500082 23.237949999999998 1.28141E-12 16.89770928324232 25.800621595393604 16.466653416530924 54.75098687500009 55.5038 1.28142E-12 40.99087275062584 66.6897608534479 39.456103431265475 11.5 47.9619 0.348134;15.797;42.4094;0.520151;38.674;16.4324;57.1163;42.2579;89.1011;1.28141E-12;59.5777;28.5803;0.750017;49.6922;26.8037;46.2316 0.118102;13.013;26.2988;0.160202;24.6273;10.5224;39.6402;23.9469;60.3265;1.28141E-12;31.0499;22.529;0.186019;35.6654;20.9825;31.1788 1.15962;19.9134;81.7305;2.88499;71.0786;39.929;101.869;102.383;106.138;1.28142E-12;105.243;38.8511;4.70178;81.6409;36.7081;81.7848 2 14 2 63868;25146 HSPD1_8849;CYP17A1_32365 45.975049999999996 45.975049999999996 5.256843943375197 29.80615 29.80615 8.286230815334557 92.01195 92.01195 14.66687956604945 42.2579;49.6922 23.9469;35.6654 102.383;81.6409 14 79426;24648;83516;25493;89783;24516;54404;24471;314322;25661;361969;24330;25698;25303 ZFP36_10204;SERPINA1_9807;PPARGC1A_33189;NFKBIA_9307;LAPTM5_32639;JUN_8938;ITIH4_32725;HSPB1_8847;FOS_8657;FN1_8655;FGA_8632;EGR1_8533;ASS1_33159;ABCC2_32541 30.167271571428664 27.692 27.028861654783388 20.04519450000009 21.75575 17.645207723153124 49.427992142857235 39.39005 40.96454265093347 0.348134;15.797;42.4094;0.520151;38.674;16.4324;57.1163;89.1011;1.28141E-12;59.5777;28.5803;0.750017;26.8037;46.2316 0.118102;13.013;26.2988;0.160202;24.6273;10.5224;39.6402;60.3265;1.28141E-12;31.0499;22.529;0.186019;20.9825;31.1788 1.15962;19.9134;81.7305;2.88499;71.0786;39.929;101.869;106.138;1.28142E-12;105.243;38.8511;4.70178;36.7081;81.7848 0 Exp 2,5(0.32);Exp 3,1(0.07);Exp 4,1(0.07);Hill,3(0.19);Linear,3(0.19);Poly 2,2(0.13);Power,1(0.07) 1.9072776053261962 31.47852325439453 1.5197933912277222 4.21828556060791 0.6254739850490832 1.8567861318588257 19.51542867765548 44.771059072344684 12.985436388711344 29.54519148628882 34.66545922719342 74.83651452280675 DOWN 0.125 0.875 0.0 GO:0043666 7 regulation of phosphoprotein phosphatase activity 19 22 2 2 2 2 2 2 160 20 2365 0.83934 0.41295 0.64706 9.09 25106;192280 rgn;ppp1r3b RGN_9699;PPP1R3B_9545 56.79090000000001 56.79090000000001 36.1411 29.203227220291925 51.42821263255285 28.20127033447333 42.916000000000004 42.916000000000004 27.0588 22.425467301262632 38.797935606006696 21.656054002838296 71.71455 71.71455 53.6244 25.58333547536364 67.0165955946196 24.705576351401557 0.5 56.79090000000001 77.4407;36.1411 58.7732;27.0588 89.8047;53.6244 1 1 1 25106 RGN_9699 77.4407 77.4407 58.7732 58.7732 89.8047 89.8047 77.4407 58.7732 89.8047 1 192280 PPP1R3B_9545 36.1411 36.1411 27.0588 27.0588 53.6244 53.6244 36.1411 27.0588 53.6244 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.7981136288093034 3.599785327911377 1.7198865413665771 1.8798987865447998 0.11314574363840568 1.7998926639556885 16.31729200000001 97.264508 11.835888000000008 73.996112 36.25785600000002 107.17124399999999 CONFLICT 0.5 0.5 0.0 GO:0044255 4 cellular lipid metabolic process 218 243 68 68 46 59 38 38 124 205 2180 1.0 4.4746E-8 4.4746E-8 15.64 24856;29573;65192;246074;83516;29441;25513;24539;25675;171155;113965;85255;81869;29328;295143;65030;25315;171142;291075;29740;298541;65210;24894;83842;497840;362866;29184;25284;65183;362732;50681;192272;170570;50559;24158;25287;170465;313917 ttr;slc37a4;slc27a2;scd;ppargc1a;por;pik3r1;lpl;hmgcr;hadhb;hadh;hacl1;gstm7;gpx4;etfdh;ephx2;ephx1;ehhadh;eci2;eci1;dhdds;cyp2j4;cyp2a1;crot;cps1;chpt1;cd36;amacr;aldh3a2;agmo;acox1;acot2;acot12;acot1;acadm;acadl;acaa2;abhd1 TTR_10102;SLC37A4_9871;SLC27A2_9860;SCD1_9787;PPARGC1A_33189;POR_9531;PIK3R1_32562;LPL_32544;HMGCR_8810;HADHB_8777;HADH_8776;HACL1_8775;GSTM7_8761;GPX4_32827;ETFDH_8575;EPHX2_33282;EPHX1_8567;EHHADH_8534;ECI2_8521;ECI1_8520;DHDDS_8467;CYP2J4_32580;CYP2A1_32717;CROT_8384;CPS1_32421;CHPT1_33298;CD36_8243;AMACR_8038;ALDH3A2_8024;AGMO_33265;ACOX1_7973;ACOT2_7969;ACOT12_32718;ACOT1_7968;ACADM_7957;ACADL_32776;ACAA2_7955;ABHD1_7949 29.057730526315787 28.464750000000002 1.63089 20.969753670899166 30.627332388548574 20.026214486209945 20.81518965789474 22.030299999999997 0.663137 13.887097316122787 21.987218113424184 13.30049459382609 53.59830552631579 41.35015 3.73641 68.45765553441935 54.63770799995001 61.407556898952215 11.5 16.6727 23.5 32.64755 46.6406;39.7166;7.62189;105.46;42.4094;12.4414;18.7324;74.2041;1.63089;31.8029;33.3125;17.6275;42.3152;45.9204;18.1231;38.7293;12.4747;8.62809;10.6467;11.9473;47.9438;17.8395;55.3937;7.4229;31.9826;16.0559;48.1296;2.03774;43.1079;31.5332;23.1906;8.54905;30.3423;31.2018;11.7137;33.4878;26.5872;17.2895 28.5876;22.6911;5.49916;63.7532;26.2988;8.48981;11.6701;49.8682;0.663137;25.5756;25.7336;11.195;31.4035;34.2198;14.869;29.2097;7.00435;7.31865;8.92359;7.15307;36.5688;14.6501;38.7444;5.75707;24.4836;10.6021;37.5433;1.165;31.8774;24.5474;16.2815;7.19676;24.0157;26.858;8.36151;26.6039;21.3695;14.2242 63.7146;60.0334;13.3925;422.699;81.7305;79.2355;41.5978;155.425;7.6286;42.1484;46.9856;37.6534;64.5991;70.4292;23.0103;57.2113;23.684;10.3909;13.0581;19.001;71.3742;22.6149;96.8569;10.316;45.5891;29.905;69.1421;3.73641;66.3058;43.8459;33.4539;10.4125;41.1025;37.2719;18.9642;45.3228;35.0407;21.8526 32 6 32 24856;65192;246074;24539;171155;113965;85255;81869;29328;295143;65030;25315;171142;291075;29740;298541;65210;24894;83842;362866;29184;25284;65183;362732;50681;192272;170570;50559;24158;25287;170465;313917 TTR_10102;SLC27A2_9860;SCD1_9787;LPL_32544;HADHB_8777;HADH_8776;HACL1_8775;GSTM7_8761;GPX4_32827;ETFDH_8575;EPHX2_33282;EPHX1_8567;EHHADH_8534;ECI2_8521;ECI1_8520;DHDDS_8467;CYP2J4_32580;CYP2A1_32717;CROT_8384;CHPT1_33298;CD36_8243;AMACR_8038;ALDH3A2_8024;AGMO_33265;ACOX1_7973;ACOT2_7969;ACOT12_32718;ACOT1_7968;ACADM_7957;ACADL_32776;ACAA2_7955;ABHD1_7949 29.9150146875 28.464750000000002 21.858144704710075 21.771270625000003 22.6926 14.388116088289086 53.7787721875 37.46265 73.96297246782369 46.6406;7.62189;105.46;74.2041;31.8029;33.3125;17.6275;42.3152;45.9204;18.1231;38.7293;12.4747;8.62809;10.6467;11.9473;47.9438;17.8395;55.3937;7.4229;16.0559;48.1296;2.03774;43.1079;31.5332;23.1906;8.54905;30.3423;31.2018;11.7137;33.4878;26.5872;17.2895 28.5876;5.49916;63.7532;49.8682;25.5756;25.7336;11.195;31.4035;34.2198;14.869;29.2097;7.00435;7.31865;8.92359;7.15307;36.5688;14.6501;38.7444;5.75707;10.6021;37.5433;1.165;31.8774;24.5474;16.2815;7.19676;24.0157;26.858;8.36151;26.6039;21.3695;14.2242 63.7146;13.3925;422.699;155.425;42.1484;46.9856;37.6534;64.5991;70.4292;23.0103;57.2113;23.684;10.3909;13.0581;19.001;71.3742;22.6149;96.8569;10.316;29.905;69.1421;3.73641;66.3058;43.8459;33.4539;10.4125;41.1025;37.2719;18.9642;45.3228;35.0407;21.8526 6 29573;83516;29441;25513;25675;497840 SLC37A4_9871;PPARGC1A_33189;POR_9531;PIK3R1_32562;HMGCR_8810;CPS1_32421 24.48554833333333 25.3575 16.186110153388206 15.716091166666667 17.1806 10.321766309920031 52.63581666666667 52.81125 27.589532691469543 39.7166;42.4094;12.4414;18.7324;1.63089;31.9826 22.6911;26.2988;8.48981;11.6701;0.663137;24.4836 60.0334;81.7305;79.2355;41.5978;7.6286;45.5891 0 Exp 2,13(0.35);Exp 4,2(0.06);Hill,3(0.08);Linear,11(0.29);Poly 2,8(0.22);Power,1(0.03) 2.8967105727906843 480.33087623119354 1.520427942276001 344.14306640625 55.497527628197886 1.9445028901100159 22.390313773455425 35.72514727917615 16.399731720369562 25.230647595419907 31.831921116891316 75.36468993574027 UP 0.8421052631578947 0.15789473684210525 0.0 GO:0050730 9 regulation of peptidyl-tyrosine phosphorylation 89 95 5 5 3 5 3 3 159 92 2293 0.13395 0.94857 0.28023 3.16 29496;29184;25373 erbb3;cd36;ahsg ERBB3_8571;CD36_8243;AHSG_8003 40.51 48.1296 12.402 25.1782892858113 45.4247660480291 21.050927765981104 29.816066666666668 37.5433 10.3013 17.021783031261247 33.58517295288014 14.179985796752604 66.1792 69.1421 15.4235 49.34101534595736 73.47299441086805 42.50790195941157 60.9984;48.1296;12.402 41.6036;37.5433;10.3013 113.972;69.1421;15.4235 2 1 2 29496;29184 ERBB3_8571;CD36_8243 54.564 54.564 9.099615745733429 39.57345 39.57345 2.871065663651677 91.55705 91.55705 31.69952628991479 60.9984;48.1296 41.6036;37.5433 113.972;69.1421 1 25373 AHSG_8003 12.402 12.402 10.3013 10.3013 15.4235 15.4235 12.402 10.3013 15.4235 0 Exp 2,2(0.67);Linear,1(0.34) 2.448140670386019 7.703033447265625 1.6013026237487793 3.431420087814331 0.9193653355778181 2.6703107357025146 12.018083490081047 69.00191650991894 10.554105876901932 49.0780274564314 10.344584955527253 122.01381504447276 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0065008 3 regulation of biological quality 821 880 95 94 73 81 62 62 100 818 1567 0.86715 0.17239 0.30656 7.05 79426;24856;24825;360268;29573;29482;293615;79224;246074;25106;83516;29441;298199;85253;25513;360722;81819;25591;294103;24314;81525;25493;24567;100359982;24539;288001;24516;81678;364070;63868;29540;289456;25675;24443;113965;81869;290556;24957;24384;289388;294515;25661;361969;304929;24890;65030;24330;25428;25146;497840;113936;170945;81718;29184;79431;25698;155423;25373;50681;25287;170465;25303 zfp36;ttr;tf;sult1e1;slc37a4;slc1a2;sirt3;serpind1;scd;rgn;ppargc1a;por;plin2;plg;pik3r1;pdia5;pax8;parp1;papss2;nqo1;nfkbib;nfkbia;mt1;mpc2;lpl;kng1;jun;itpr2;iars2;hspd1;hsd17b7;hsd17b11;hmgcr;hdc;hadh;gstm7;gnl3;glul;gc;g0s2;foxo3;fn1;fga;f5;esr1;ephx2;egr1;cyp7a1;cyp17a1;cps1;cpb2;chrna2;cdo1;cd36;bhlhe40;ass1;anxa7;ahsg;acox1;acadl;acaa2;abcc2 ZFP36_10204;TTR_10102;TF_10003;SULT1E1_32446;SLC37A4_9871;SLC1A2_33059;SIRT3_9828;SERPIND1_9812;SCD1_9787;RGN_9699;PPARGC1A_33189;POR_9531;PLIN2_9502;PLG_9501;PIK3R1_32562;PDIA5_9451;PAX8_9432;PARP1_9425;PAPSS2_33237;NQO1_33055;NFKBIB_9308;NFKBIA_9307;MT1A_9255;MPC2_33219;LPL_32544;KNG1L1_34113;JUN_8938;ITPR2_8931;IARS2_8858;HSPD1_8849;HSD17B7_8834;HSD17B11_8832;HMGCR_8810;HDC_8788;HADH_8776;GSTM7_8761;GNL3_8735;GLUL_32832;GC_32893;G0S2_32729;FOXO3_8662;FN1_8655;FGA_8632;F5_33079;ESR1_33192;EPHX2_33282;EGR1_8533;CYP7A1_8430;CYP17A1_32365;CPS1_32421;CPB2_8369;CHRNA2_32401;CDO1_8275;CD36_8243;BHLHE40_8141;ASS1_33159;ANXA7_8051;AHSG_8003;ACOX1_7973;ACADL_32776;ACAA2_7955;ABCC2_32541 36.51657654838709 31.184150000000002 0.348134 25.987293854310295 38.757484036351315 22.941373310117662 24.957347661290328 23.319 0.118102 16.217646547371512 26.68480439325735 14.227668698043535 64.38966741935485 44.8262 1.15962 64.32089061143155 65.90101048561289 56.314580152989066 43.0 46.2316 0.348134;46.6406;45.1539;50.1846;39.7166;13.3235;2.38018;28.261;105.46;77.4407;42.4094;12.4414;25.6517;70.7857;18.7324;107.066;56.8931;26.9741;34.4443;87.2765;30.5572;0.520151;12.9315;46.8463;74.2041;24.3655;16.4324;31.8111;24.7304;42.2579;0.977494;22.4334;1.63089;24.5745;33.3125;42.3152;87.6357;26.4669;42.356;46.3784;13.1992;59.5777;28.5803;10.6089;23.3972;38.7293;0.750017;5.72128;49.6922;31.9826;25.8316;49.3913;22.9638;48.1296;57.8085;26.8037;104.64;12.402;23.1906;33.4878;26.5872;46.2316 0.118102;28.5876;28.132;36.5009;22.6911;9.10952;0.56209;22.307;63.7532;58.7732;26.2988;8.48981;20.9252;46.2356;11.6701;61.3361;45.1162;21.799;25.719;60.6992;24.2439;0.160202;8.91033;35.8494;49.8682;19.538;10.5224;24.7342;19.8021;23.9469;0.322682;18.1233;0.663137;21.0619;25.7336;31.4035;54.41;21.0456;26.3722;33.7914;5.6804;31.0499;22.529;2.59129;18.3088;29.2097;0.186019;0.985273;35.6654;24.4836;20.4374;41.8524;18.5144;37.5433;38.3491;20.9825;43.9254;10.3013;16.2815;26.6039;21.3695;31.1788 1.15962;63.7146;61.5341;80.9788;60.0334;24.6773;8.82917;38.3264;422.699;89.8047;81.7305;79.2355;33.0375;150.579;41.5978;114.259;81.5688;35.2797;51.1014;197.117;41.2611;2.88499;23.4636;69.127;155.425;32.1467;39.929;44.3296;32.7087;102.383;5.49472;29.2247;7.6286;29.28;46.9856;64.5991;238.963;35.4303;78.7583;73.6529;32.7581;105.243;38.8511;37.5078;31.9156;57.2113;4.70178;22.3625;81.6409;45.5891;34.8042;62.472;30.0179;69.1421;110.58;36.7081;108.689;15.4235;33.4539;45.3228;35.0407;81.7848 29 33 29 24856;24825;360268;293615;246074;25106;298199;81819;25591;24314;81525;100359982;24539;364070;63868;289456;24443;113965;81869;290556;289388;65030;25146;170945;29184;155423;50681;25287;170465 TTR_10102;TF_10003;SULT1E1_32446;SIRT3_9828;SCD1_9787;RGN_9699;PLIN2_9502;PAX8_9432;PARP1_9425;NQO1_33055;NFKBIB_9308;MPC2_33219;LPL_32544;IARS2_8858;HSPD1_8849;HSD17B11_8832;HDC_8788;HADH_8776;GSTM7_8761;GNL3_8735;G0S2_32729;EPHX2_33282;CYP17A1_32365;CHRNA2_32401;CD36_8243;ANXA7_8051;ACOX1_7973;ACADL_32776;ACAA2_7955 47.34996482758621 45.1539 25.34724760829673 32.949444482758615 29.2097 14.762512475691747 84.52228172413793 63.7146 82.27470471393102 46.6406;45.1539;50.1846;2.38018;105.46;77.4407;25.6517;56.8931;26.9741;87.2765;30.5572;46.8463;74.2041;24.7304;42.2579;22.4334;24.5745;33.3125;42.3152;87.6357;46.3784;38.7293;49.6922;49.3913;48.1296;104.64;23.1906;33.4878;26.5872 28.5876;28.132;36.5009;0.56209;63.7532;58.7732;20.9252;45.1162;21.799;60.6992;24.2439;35.8494;49.8682;19.8021;23.9469;18.1233;21.0619;25.7336;31.4035;54.41;33.7914;29.2097;35.6654;41.8524;37.5433;43.9254;16.2815;26.6039;21.3695 63.7146;61.5341;80.9788;8.82917;422.699;89.8047;33.0375;81.5688;35.2797;197.117;41.2611;69.127;155.425;32.7087;102.383;29.2247;29.28;46.9856;64.5991;238.963;73.6529;57.2113;81.6409;62.472;69.1421;108.689;33.4539;45.3228;35.0407 33 79426;29573;29482;79224;83516;29441;85253;25513;360722;294103;25493;24567;288001;24516;81678;29540;25675;24957;24384;294515;25661;361969;304929;24890;24330;25428;497840;113936;81718;79431;25698;25373;25303 ZFP36_10204;SLC37A4_9871;SLC1A2_33059;SERPIND1_9812;PPARGC1A_33189;POR_9531;PLG_9501;PIK3R1_32562;PDIA5_9451;PAPSS2_33237;NFKBIA_9307;MT1A_9255;KNG1L1_34113;JUN_8938;ITPR2_8931;HSD17B7_8834;HMGCR_8810;GLUL_32832;GC_32893;FOXO3_8662;FN1_8655;FGA_8632;F5_33079;ESR1_33192;EGR1_8533;CYP7A1_8430;CPS1_32421;CPB2_8369;CDO1_8275;BHLHE40_8141;ASS1_33159;AHSG_8003;ABCC2_32541 26.996326242424246 24.3655 22.920866459606223 17.93398984848485 19.538 14.209923790915552 46.69736999999999 37.5078 35.68452119955322 0.348134;39.7166;13.3235;28.261;42.4094;12.4414;70.7857;18.7324;107.066;34.4443;0.520151;12.9315;24.3655;16.4324;31.8111;0.977494;1.63089;26.4669;42.356;13.1992;59.5777;28.5803;10.6089;23.3972;0.750017;5.72128;31.9826;25.8316;22.9638;57.8085;26.8037;12.402;46.2316 0.118102;22.6911;9.10952;22.307;26.2988;8.48981;46.2356;11.6701;61.3361;25.719;0.160202;8.91033;19.538;10.5224;24.7342;0.322682;0.663137;21.0456;26.3722;5.6804;31.0499;22.529;2.59129;18.3088;0.186019;0.985273;24.4836;20.4374;18.5144;38.3491;20.9825;10.3013;31.1788 1.15962;60.0334;24.6773;38.3264;81.7305;79.2355;150.579;41.5978;114.259;51.1014;2.88499;23.4636;32.1467;39.929;44.3296;5.49472;7.6286;35.4303;78.7583;32.7581;105.243;38.8511;37.5078;31.9156;4.70178;22.3625;45.5891;34.8042;30.0179;110.58;36.7081;15.4235;81.7848 0 Exp 2,24(0.39);Exp 3,4(0.07);Exp 4,4(0.07);Hill,5(0.09);Linear,14(0.23);Poly 2,9(0.15);Power,2(0.04) 2.0746918790184137 145.9703253507614 1.5209722518920898 17.513065338134766 2.1233849118520105 1.8701979517936707 30.047812893405293 42.98534020336891 20.920447045815965 28.99424827676467 48.37889531757721 80.40043952113251 CONFLICT 0.46774193548387094 0.532258064516129 0.0 GO:0050707 6 regulation of cytokine secretion 61 67 10 10 6 10 6 6 156 61 2324 0.86996 0.25099 0.31647 8.96 25591;24539;63868;25661;65210;29184 parp1;lpl;hspd1;fn1;cyp2j4;cd36 PARP1_9425;LPL_32544;HSPD1_8849;FN1_8655;CYP2J4_32580;CD36_8243 44.830483333333326 45.19375 17.8395 20.713066978737526 46.564680193078615 20.792426851043256 29.809566666666665 27.4984 14.6501 12.586081976797505 30.835733058578086 12.590072934261851 81.68128333333333 85.76255 22.6149 49.438905747656555 83.965753587499 49.48456502240502 2.5 45.19375 26.9741;74.2041;42.2579;59.5777;17.8395;48.1296 21.799;49.8682;23.9469;31.0499;14.6501;37.5433 35.2797;155.425;102.383;105.243;22.6149;69.1421 5 1 5 25591;24539;63868;65210;29184 PARP1_9425;LPL_32544;HSPD1_8849;CYP2J4_32580;CD36_8243 41.88104 42.2579 21.703566751988028 29.561500000000002 23.9469 14.055258673357812 76.96894 69.1421 53.74672459064833 26.9741;74.2041;42.2579;17.8395;48.1296 21.799;49.8682;23.9469;14.6501;37.5433 35.2797;155.425;102.383;22.6149;69.1421 1 25661 FN1_8655 59.5777 59.5777 31.0499 31.0499 105.243 105.243 59.5777 31.0499 105.243 0 Exp 2,3(0.5);Exp 3,1(0.17);Linear,1(0.17);Power,1(0.17) 2.204910297319325 13.877443790435791 1.559399127960205 3.8079800605773926 0.833492108727557 2.030260145664215 28.256577932040486 61.40438873462618 19.738603623362067 39.88052970997128 42.121919775719064 121.24064689094762 UP 0.8333333333333334 0.16666666666666666 0.0 GO:0051235 3 maintenance of location 47 50 5 5 4 5 4 4 158 46 2339 0.79064 0.3946 0.55628 8.0 298199;81525;25493;29184 plin2;nfkbib;nfkbia;cd36 PLIN2_9502;NFKBIB_9308;NFKBIA_9307;CD36_8243 26.214662750000002 28.10445 0.520151 19.66084913025419 35.93339627351341 14.740530361509942 20.7181505 22.58455 0.160202 15.472434426620387 28.254660468713563 11.407662853789834 36.5814225 37.1493 2.88499 27.264788346119463 50.344727927516516 21.62629632567659 1.5 28.10445 25.6517;30.5572;0.520151;48.1296 20.9252;24.2439;0.160202;37.5433 33.0375;41.2611;2.88499;69.1421 3 1 3 298199;81525;29184 PLIN2_9502;NFKBIB_9308;CD36_8243 34.779500000000006 30.5572 11.818834970926703 27.570800000000002 24.2439 8.794402174679073 47.81356666666667 41.2611 18.923177583411665 25.6517;30.5572;48.1296 20.9252;24.2439;37.5433 33.0375;41.2611;69.1421 1 25493 NFKBIA_9307 0.520151 0.520151 0.160202 0.160202 2.88499 2.88499 0.520151 0.160202 2.88499 0 Exp 2,3(0.75);Exp 4,1(0.25) 2.0320001776384102 8.304856657981873 1.5302108526229858 2.6703107357025146 0.4933855266062676 2.052167534828186 6.9470306023508925 45.48229489764911 5.555164761912023 35.881136238087976 9.861929920802933 63.30091507919707 UP 0.75 0.25 0.0 GO:2000147 6 positive regulation of cell motility 188 196 11 11 11 8 8 8 154 188 2197 0.10914 0.94247 0.22145 4.08 24825;85253;25513;24516;24471;25661;361969;24330 tf;plg;pik3r1;jun;hspb1;fn1;fga;egr1 TF_10003;PLG_9501;PIK3R1_32562;JUN_8938;HSPB1_8847;FN1_8655;FGA_8632;EGR1_8533 41.139189625 36.8671 0.750017 30.3241008282583 45.66161233769672 29.373731570465914 26.331439875 25.3305 0.186019 19.785520666575636 29.047315406646916 18.965457238227817 68.57172249999999 51.56595 4.70178 47.87097613987647 75.09293909757452 48.93330876387671 45.1539;70.7857;18.7324;16.4324;89.1011;59.5777;28.5803;0.750017 28.132;46.2356;11.6701;10.5224;60.3265;31.0499;22.529;0.186019 61.5341;150.579;41.5978;39.929;106.138;105.243;38.8511;4.70178 1 7 1 24825 TF_10003 45.1539 45.1539 28.132 28.132 61.5341 61.5341 45.1539 28.132 61.5341 7 85253;25513;24516;24471;25661;361969;24330 PLG_9501;PIK3R1_32562;JUN_8938;HSPB1_8847;FN1_8655;FGA_8632;EGR1_8533 40.56565957142857 28.5803 32.7068728272949 26.074217 22.529 21.356352038354377 69.57709714285714 41.5978 51.615257625422394 70.7857;18.7324;16.4324;89.1011;59.5777;28.5803;0.750017 46.2356;11.6701;10.5224;60.3265;31.0499;22.529;0.186019 150.579;41.5978;39.929;106.138;105.243;38.8511;4.70178 0 Hill,1(0.13);Linear,2(0.25);Poly 2,4(0.5);Power,1(0.13) 1.9165080810006971 16.248758792877197 1.5254690647125244 4.21828556060791 0.8962509951124211 1.7382755875587463 20.125659842534876 62.15271940746513 12.620773559010631 40.042106190989365 35.39882848648446 101.74461651351555 DOWN 0.125 0.875 0.0 GO:0090207 6 regulation of triglyceride metabolic process 24 26 5 5 4 5 4 4 158 22 2363 0.97838 0.078889 0.078889 15.38 25357;25106;24890;29184 thrsp;rgn;esr1;cd36 THRSP_33314;RGN_9699;ESR1_33192;CD36_8243 45.2932 40.16745 23.3972 23.75033237395498 50.43788108720843 20.789376310838442 34.755475000000004 30.96995 18.3088 17.911099838065965 38.77333622852537 15.648595009985266 59.3673 57.874449999999996 31.9156 25.4192068256794 66.7617564763968 20.947020476535684 0.5 27.801250000000003 1.5 40.16745 32.2053;77.4407;23.3972;48.1296 24.3966;58.7732;18.3088;37.5433 46.6068;89.8047;31.9156;69.1421 2 2 2 25106;29184 RGN_9699;CD36_8243 62.78515 62.78515 20.726077574037024 48.15825 48.15825 15.0118062539123 79.4734 79.4734 14.610664576945227 77.4407;48.1296 58.7732;37.5433 89.8047;69.1421 2 25357;24890 THRSP_33314;ESR1_33192 27.801250000000003 27.801250000000003 6.228267239369208 21.3527 21.3527 4.304724662507479 39.2612 39.2612 10.388247143767783 32.2053;23.3972 24.3966;18.3088 46.6068;31.9156 0 Exp 2,3(0.75);Poly 2,1(0.25) 2.375762705683197 9.673594236373901 1.7198865413665771 2.8464107513427734 0.4949473780236027 2.5536484718322754 22.017874273524132 68.56852572647588 17.202597158695355 52.308352841304654 34.456477310834174 84.27812268916583 CONFLICT 0.5 0.5 0.0 GO:0031325 6 positive regulation of cellular metabolic process 693 746 54 54 43 45 36 36 126 710 1675 0.023362 0.98526 0.040503 4.83 79426;246273;24825;293615;25106;83516;29441;303612;25513;81819;25591;25493;58954;24516;494344;63868;24471;25675;290556;29455;299626;25112;294515;314322;25661;361969;24360;24890;29496;24330;25146;25423;25695;114851;29184;25698 zfp36;trib3;tf;sirt3;rgn;ppargc1a;por;polg2;pik3r1;pax8;parp1;nfkbia;klf6;jun;ier2;hspd1;hspb1;hmgcr;gnl3;gdf15;gadd45b;gadd45a;foxo3;fos;fn1;fga;fabp1;esr1;erbb3;egr1;cyp17a1;ctsc;cebpd;cdkn1a;cd36;ass1 ZFP36_10204;TRIB3_10079;TF_10003;SIRT3_9828;RGN_9699;PPARGC1A_33189;POR_9531;POLG2_9521;PIK3R1_32562;PAX8_9432;PARP1_9425;NFKBIA_9307;KLF6_8969;JUN_8938;IER2_32643;HSPD1_8849;HSPB1_8847;HMGCR_8810;GNL3_8735;GDF15_33113;GADD45B_8679;GADD45A_8678;FOXO3_8662;FOS_8657;FN1_8655;FGA_8632;FABP1_33091;ESR1_33192;ERBB3_8571;EGR1_8533;CYP17A1_32365;CTSC_32456;CEBPD_8283;CDKN1A_8271;CD36_8243;ASS1_33159 41.195182722222256 38.05285 1.28141E-12 34.2639868822748 44.722276588536886 32.26550715046189 28.5930901166667 25.12285 1.28141E-12 25.30699662312125 31.917370223159164 25.367334758835206 67.38102361111115 65.3381 1.28142E-12 51.969220729310706 70.1623407734824 42.85040753965283 0.348134;108.064;45.1539;2.38018;77.4407;42.4094;12.4414;63.7758;18.7324;56.8931;26.9741;0.520151;18.9476;16.4324;49.6814;42.2579;89.1011;1.63089;87.6357;105.149;106.367;102.919;13.1992;1.28141E-12;59.5777;28.5803;33.8478;23.3972;60.9984;0.750017;49.6922;56.2386;0.306936;6.24967;48.1296;26.8037 0.118102;83.8836;28.132;0.56209;58.7732;26.2988;8.48981;40.9553;11.6701;45.1162;21.799;0.160202;11.6941;10.5224;33.4626;23.9469;60.3265;0.663137;54.41;85.3487;52.7132;89.5012;5.6804;1.28141E-12;31.0499;22.529;26.4736;18.3088;41.6036;0.186019;35.6654;38.2681;0.0732342;2.44025;37.5433;20.9825 1.15962;143.428;61.5341;8.82917;89.8047;81.7305;79.2355;132.567;41.5978;81.5688;35.2797;2.88499;45.5481;39.929;89.4404;102.383;106.138;7.6286;238.963;125.652;109.434;115.437;32.7581;1.28142E-12;105.243;38.8511;46.9257;31.9156;113.972;4.70178;81.6409;102.888;1.73689;19.0606;69.1421;36.7081 12 24 12 24825;293615;25106;81819;25591;63868;290556;299626;24360;29496;25146;29184 TF_10003;SIRT3_9828;RGN_9699;PAX8_9432;PARP1_9425;HSPD1_8849;GNL3_8735;GADD45B_8679;FABP1_33091;ERBB3_8571;CYP17A1_32365;CD36_8243 53.14754833333333 48.9109 27.866601631089708 35.56154083333333 36.60435 16.53376382760742 86.62309749999999 81.60485 57.19470496080975 45.1539;2.38018;77.4407;56.8931;26.9741;42.2579;87.6357;106.367;33.8478;60.9984;49.6922;48.1296 28.132;0.56209;58.7732;45.1162;21.799;23.9469;54.41;52.7132;26.4736;41.6036;35.6654;37.5433 61.5341;8.82917;89.8047;81.5688;35.2797;102.383;238.963;109.434;46.9257;113.972;81.6409;69.1421 24 79426;246273;83516;29441;303612;25513;25493;58954;24516;494344;24471;25675;29455;25112;294515;314322;25661;361969;24890;24330;25423;25695;114851;25698 ZFP36_10204;TRIB3_10079;PPARGC1A_33189;POR_9531;POLG2_9521;PIK3R1_32562;NFKBIA_9307;KLF6_8969;JUN_8938;IER2_32643;HSPB1_8847;HMGCR_8810;GDF15_33113;GADD45A_8678;FOXO3_8662;FOS_8657;FN1_8655;FGA_8632;ESR1_33192;EGR1_8533;CTSC_32456;CEBPD_8283;CDKN1A_8271;ASS1_33159 35.21899991666672 21.172400000000003 36.10205507799175 25.108864758333386 15.001450000000002 28.387425589268858 57.75998666666673 40.763400000000004 47.49360883570709 0.348134;108.064;42.4094;12.4414;63.7758;18.7324;0.520151;18.9476;16.4324;49.6814;89.1011;1.63089;105.149;102.919;13.1992;1.28141E-12;59.5777;28.5803;23.3972;0.750017;56.2386;0.306936;6.24967;26.8037 0.118102;83.8836;26.2988;8.48981;40.9553;11.6701;0.160202;11.6941;10.5224;33.4626;60.3265;0.663137;85.3487;89.5012;5.6804;1.28141E-12;31.0499;22.529;18.3088;0.186019;38.2681;0.0732342;2.44025;20.9825 1.15962;143.428;81.7305;79.2355;132.567;41.5978;2.88499;45.5481;39.929;89.4404;106.138;7.6286;125.652;115.437;32.7581;1.28142E-12;105.243;38.8511;31.9156;4.70178;102.888;1.73689;19.0606;36.7081 0 Exp 2,11(0.31);Exp 3,1(0.03);Exp 4,4(0.12);Hill,5(0.14);Linear,3(0.09);Poly 2,10(0.28);Power,2(0.06) 1.8293882196115925 67.29045712947845 1.5209722518920898 4.21828556060791 0.47522398891276063 1.772010862827301 30.002280340679157 52.388085103765356 20.326137886447093 36.86004234688631 50.404411506203004 84.35763571601935 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0034654 5 nucleobase-containing compound biosynthetic process 143 160 17 17 14 15 12 12 150 148 2237 0.7867 0.31675 0.50394 7.5 298490;303612;24651;81819;294103;100359982;24516;294515;314322;24890;24330;25028 ppcs;polg2;pklr;pax8;papss2;mpc2;jun;foxo3;fos;esr1;egr1;ampd1 PPCS_9540;POLG2_9521;PKLR_9489;PAX8_9432;PAPSS2_33237;MPC2_33219;JUN_8938;FOXO3_8662;FOS_8657;ESR1_33192;EGR1_8533;AMPD1_32743 30.006201416666773 23.24675 1.28141E-12 22.420066907915295 34.46653473423818 23.8233763872811 22.218968250000103 17.88565 1.28141E-12 17.335757095495396 26.190776531268476 18.729299155678486 48.74554833333344 36.43665 1.28142E-12 37.40367464286247 53.95482585261428 37.92762293561341 7.0 34.4443 20.3353;63.7758;23.0963;56.8931;34.4443;46.8463;16.4324;13.1992;1.28141E-12;23.3972;0.750017;60.9045 16.7643;40.9553;17.4625;45.1162;25.719;35.8494;10.5224;5.6804;1.28141E-12;18.3088;0.186019;50.0633 25.6711;132.567;32.9443;81.5688;51.1014;69.127;39.929;32.7581;1.28142E-12;31.9156;4.70178;82.6625 4 8 4 298490;81819;100359982;25028 PPCS_9540;PAX8_9432;MPC2_33219;AMPD1_32743 46.2448 51.869699999999995 18.25702686164062 36.9483 40.4828 14.68921659608389 64.75735 75.3479 26.770929680096383 20.3353;56.8931;46.8463;60.9045 16.7643;45.1162;35.8494;50.0633 25.6711;81.5688;69.127;82.6625 8 303612;24651;294103;24516;294515;314322;24890;24330 POLG2_9521;PKLR_9489;PAPSS2_33237;JUN_8938;FOXO3_8662;FOS_8657;ESR1_33192;EGR1_8533 21.88690212500016 19.76435 20.518785151053297 14.85430237500016 13.992449999999998 13.922103080994615 40.73964750000016 32.8512 40.88497604114368 63.7758;23.0963;34.4443;16.4324;13.1992;1.28141E-12;23.3972;0.750017 40.9553;17.4625;25.719;10.5224;5.6804;1.28141E-12;18.3088;0.186019 132.567;32.9443;51.1014;39.929;32.7581;1.28142E-12;31.9156;4.70178 0 Exp 2,8(0.67);Exp 4,1(0.09);Hill,2(0.17);Poly 2,1(0.09) 2.097973506231558 26.189624667167664 1.5504547357559204 4.21828556060791 0.7284940561744906 1.9504427313804626 17.320854385423132 42.69154844791041 12.410340304823679 32.027596195176535 27.58242714207037 69.9086695245965 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:1903322 9 positive regulation of protein modification by small protein conjugation or removal 39 40 3 3 2 3 2 2 160 38 2347 0.527 0.73412 1.0 5.0 246273;290556 trib3;gnl3 TRIB3_10079;GNL3_8735 97.84985 97.84985 87.6357 14.444989458113165 103.41387898787762 12.113665146813013 69.1468 69.1468 54.41 20.84098242597978 77.17448535693671 17.47738779394807 191.19549999999998 191.19549999999998 143.428 67.55344634065686 165.1747587069463 56.650773671856925 1.0 108.064 108.064;87.6357 83.8836;54.41 143.428;238.963 1 1 1 290556 GNL3_8735 87.6357 87.6357 54.41 54.41 238.963 238.963 87.6357 54.41 238.963 1 246273 TRIB3_10079 108.064 108.064 83.8836 83.8836 143.428 143.428 108.064 83.8836 143.428 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.7235488491340256 3.459664225578308 1.582527995109558 1.87713623046875 0.208319481015887 1.729832112789154 77.83011600000002 117.86958399999999 40.262671999999995 98.030928 97.57119999999999 284.8198 CONFLICT 0.5 0.5 0.0 GO:0006417 7 regulation of translation 60 67 5 5 4 4 3 3 159 64 2321 0.37356 0.81097 0.79782 4.48 79426;294515;116636 zfp36;foxo3;eif4ebp1 ZFP36_10204;FOXO3_8662;EIF4EBP1_8550 32.48247799999999 13.1992 0.348134 44.99018074463863 53.813822541915876 46.7414098651618 16.072334 5.6804 0.118102 22.985324381762986 27.028536447545807 23.873009536825972 47.07924 32.7581 1.15962 54.50988771416429 71.64852330010443 56.392710595561724 0.348134;13.1992;83.9001 0.118102;5.6804;42.4185 1.15962;32.7581;107.32 1 2 1 116636 EIF4EBP1_8550 83.9001 83.9001 42.4185 42.4185 107.32 107.32 83.9001 42.4185 107.32 2 79426;294515 ZFP36_10204;FOXO3_8662 6.773667 6.773667 9.08707591407588 2.899251 2.899251 3.93313863478037 16.958859999999998 16.958859999999998 22.343499483187497 0.348134;13.1992 0.118102;5.6804 1.15962;32.7581 0 Exp 3,1(0.34);Exp 4,1(0.34);Hill,1(0.34) 1.8611469765318744 5.599370718002319 1.672852873802185 1.9883413314819336 0.16953176169397724 1.9381765127182007 -18.42870420906177 83.39366020906178 -9.938009109674592 42.08267710967459 -14.604504756727302 108.76298475672729 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0071407 6 cellular response to organic cyclic compound 197 209 34 34 25 30 22 22 140 187 2198 0.99457 0.010985 0.016716 10.53 79426;286954;24825;83516;24651;25493;58954;81678;81869;294515;361969;24890;25315;116636;24330;140942;25428;497840;25698;65054;312382;25303 zfp36;ugt2b1;tf;ppargc1a;pklr;nfkbia;klf6;itpr2;gstm7;foxo3;fga;esr1;ephx1;eif4ebp1;egr1;ddit4;cyp7a1;cps1;ass1;aqp9;abcg2;abcc2 ZFP36_10204;UGT2B10_33303,UGT2B1_33224;TF_10003;PPARGC1A_33189;PKLR_9489;NFKBIA_9307;KLF6_8969;ITPR2_8931;GSTM7_8761;FOXO3_8662;FGA_8632;ESR1_33192;EPHX1_8567;EIF4EBP1_8550;EGR1_8533;DDIT4_8450;CYP7A1_8430;CPS1_32421;ASS1_33159;AQP9_32709;ABCG2_32656;ABCC2_32541 29.34573509090909 27.26765 0.348134 23.85064461793299 31.167104172719963 22.12453867952441 19.386635272727272 21.459850000000003 0.118102 14.682864630927421 20.832377180497723 13.299261684786002 51.41912 38.156800000000004 1.15962 51.44203123730105 49.81520172178856 39.27895522247322 9.5 25.100450000000002 19.5 65.686775 0.348134;47.47345;45.1539;42.4094;23.0963;0.520151;18.9476;31.8111;42.3152;13.1992;28.5803;23.3972;12.4747;83.9001;0.750017;87.5421;5.72128;31.9826;26.8037;27.7316;5.21654;46.2316 0.118102;34.82915;28.132;26.2988;17.4625;0.160202;11.6941;24.7342;31.4035;5.6804;22.529;18.3088;7.00435;42.4185;0.186019;53.2453;0.985273;24.4836;20.9825;21.9372;2.73368;31.1788 1.15962;76.47475;61.5341;81.7305;32.9443;2.88499;45.5481;44.3296;64.5991;32.7581;38.8511;31.9156;23.684;107.32;4.70178;245.492;22.3625;45.5891;36.7081;37.4625;11.386;81.7848 7 16 6 286954;24825;81869;25315;116636;312382 UGT2B10_33303,UGT2B1_33224;TF_10003;GSTM7_8761;EPHX1_8567;EIF4EBP1_8550;ABCG2_32656 39.422315 43.73455 28.215325555693134 24.420196666666666 29.76775 15.927623564457654 57.499658333333336 63.06660000000001 35.1532859701112 47.47345;45.1539;42.3152;12.4747;83.9001;5.21654 34.82915;28.132;31.4035;7.00435;42.4185;2.73368 76.47475;61.5341;64.5991;23.684;107.32;11.386 16 79426;83516;24651;25493;58954;81678;294515;361969;24890;24330;140942;25428;497840;25698;65054;25303 ZFP36_10204;PPARGC1A_33189;PKLR_9489;NFKBIA_9307;KLF6_8969;ITPR2_8931;FOXO3_8662;FGA_8632;ESR1_33192;EGR1_8533;DDIT4_8450;CYP7A1_8430;CPS1_32421;ASS1_33159;AQP9_32709;ABCC2_32541 25.567017625 25.100450000000002 21.79864089717595 17.49904975 19.645650000000003 14.25913209043827 49.138918125 37.085300000000004 57.206141717905105 0.348134;42.4094;23.0963;0.520151;18.9476;31.8111;13.1992;28.5803;23.3972;0.750017;87.5421;5.72128;31.9826;26.8037;27.7316;46.2316 0.118102;26.2988;17.4625;0.160202;11.6941;24.7342;5.6804;22.529;18.3088;0.186019;53.2453;0.985273;24.4836;20.9825;21.9372;31.1788 1.15962;81.7305;32.9443;2.88499;45.5481;44.3296;32.7581;38.8511;31.9156;4.70178;245.492;22.3625;45.5891;36.7081;37.4625;81.7848 0 Exp 2,8(0.35);Exp 3,1(0.05);Exp 4,3(0.14);Hill,4(0.18);Linear,5(0.22);Poly 2,2(0.09) 1.9863887887132134 47.91099286079407 1.5074360370635986 4.560328960418701 0.786394287319578 1.8264755010604858 19.379185035459752 39.312285146358434 13.251056648093561 25.52221389736099 29.92286329526267 72.91537670473733 DOWN 0.2727272727272727 0.7272727272727273 0.0 GO:0003006 3 developmental process involved in reproduction 220 234 21 21 15 17 11 11 151 223 2162 0.17132 0.89512 0.32584 4.7 25106;85253;65164;24464;29328;294515;24890;25146;29184;25373;50681 rgn;plg;htra1;hp;gpx4;foxo3;esr1;cyp17a1;cd36;ahsg;acox1 RGN_9699;PLG_9501;HTRA1_8856;HP_8823;GPX4_32827;FOXO3_8662;ESR1_33192;CYP17A1_32365;CD36_8243;AHSG_8003;ACOX1_7973 42.01985454545454 45.9204 12.402 22.817766048163616 48.26068470675441 21.304936154099224 30.02128181818182 34.2198 5.6804 16.29934480123776 34.400261154903085 14.54139208029929 68.93317272727273 69.1421 15.4235 43.72824315480992 81.29592348857392 45.94756708277215 77.4407;70.7857;33.1323;64.9285;45.9204;13.1992;23.3972;49.6922;48.1296;12.402;23.1906 58.7732;46.2356;25.6145;41.6103;34.2198;5.6804;18.3088;35.6654;37.5433;10.3013;16.2815 89.8047;150.579;46.6629;136.455;70.4292;32.7581;31.9156;81.6409;69.1421;15.4235;33.4539 5 6 5 25106;29328;25146;29184;50681 RGN_9699;GPX4_32827;CYP17A1_32365;CD36_8243;ACOX1_7973 48.8747 48.1296 19.272005069270836 36.49664 35.6654 15.0985716885075 68.89415999999999 70.4292 21.553189524012495 77.4407;45.9204;49.6922;48.1296;23.1906 58.7732;34.2198;35.6654;37.5433;16.2815 89.8047;70.4292;81.6409;69.1421;33.4539 6 85253;65164;24464;294515;24890;25373 PLG_9501;HTRA1_8856;HP_8823;FOXO3_8662;ESR1_33192;AHSG_8003 36.30748333333333 28.26475 25.65202571536343 24.62515 21.96165 16.495200464710937 68.96568333333333 39.710499999999996 58.759541570417895 70.7857;33.1323;64.9285;13.1992;23.3972;12.402 46.2356;25.6145;41.6103;5.6804;18.3088;10.3013 150.579;46.6629;136.455;32.7581;31.9156;15.4235 0 Exp 2,5(0.46);Exp 4,1(0.1);Linear,3(0.28);Poly 2,1(0.1);Power,1(0.1) 2.1783797043222703 26.39683437347412 1.5254690647125244 5.973292827606201 1.325249589977992 1.90940523147583 28.535416515426945 55.50429257548214 20.388984579336572 39.65357905702706 43.09143240359766 94.77491305094779 CONFLICT 0.45454545454545453 0.5454545454545454 0.0 GO:0015908 7 fatty acid transport 24 27 8 8 6 8 6 6 156 21 2364 0.99889 0.0058302 0.0058302 22.22 65192;298199;24360;83842;29184;25303 slc27a2;plin2;fabp1;crot;cd36;abcc2 SLC27A2_9860;PLIN2_9502;FABP1_33091;CROT_8384;CD36_8243;ABCC2_32541 28.150914999999998 29.74975 7.4229 17.976935623229846 28.86330922073832 19.55785407004616 21.229521666666667 23.6994 5.49916 13.263193513235668 21.847292757339048 14.909427595024498 42.4331 39.9816 10.316 29.138470408653912 43.55355779261685 29.573764388063893 0.5 7.5223949999999995 1.5 16.636795 7.62189;25.6517;33.8478;7.4229;48.1296;46.2316 5.49916;20.9252;26.4736;5.75707;37.5433;31.1788 13.3925;33.0375;46.9257;10.316;69.1421;81.7848 5 1 5 65192;298199;24360;83842;29184 SLC27A2_9860;PLIN2_9502;FABP1_33091;CROT_8384;CD36_8243 24.534778 25.6517 17.489694593714894 19.239666 20.9252 13.79108175255589 34.562760000000004 33.0375 24.428388901603807 7.62189;25.6517;33.8478;7.4229;48.1296 5.49916;20.9252;26.4736;5.75707;37.5433 13.3925;33.0375;46.9257;10.316;69.1421 1 25303 ABCC2_32541 46.2316 46.2316 31.1788 31.1788 81.7848 81.7848 46.2316 31.1788 81.7848 0 Exp 2,4(0.67);Hill,1(0.17);Poly 2,1(0.17) 2.5467754498826407 16.80262315273285 1.8589661121368408 5.963563919067383 1.57777501329849 2.2172199487686157 13.766370657513498 42.535459342486504 10.616756554041743 31.84228677929159 19.117467767112952 65.74873223288705 UP 0.8333333333333334 0.16666666666666666 0.0 GO:0043604 6 amide biosynthetic process 50 60 11 11 7 9 5 5 157 55 2330 0.82131 0.33345 0.42916 8.33 298490;100359982;364070;497840;25698 ppcs;mpc2;iars2;cps1;ass1 PPCS_9540;MPC2_33219;IARS2_8858;CPS1_32421;ASS1_33159 30.139660000000003 26.8037 20.3353 10.235018878976216 31.022314265122983 10.235300634455976 23.57638 20.9825 16.7643 7.396416445617435 24.159671018738084 7.418939749662863 41.960800000000006 36.7081 25.6711 16.805605620744515 43.511815692565214 16.7563588355881 2.0 26.8037 20.3353;46.8463;24.7304;31.9826;26.8037 16.7643;35.8494;19.8021;24.4836;20.9825 25.6711;69.127;32.7087;45.5891;36.7081 3 2 3 298490;100359982;364070 PPCS_9540;MPC2_33219;IARS2_8858 30.637333333333334 24.7304 14.208348823960273 24.1386 19.8021 10.254959029172182 42.502266666666664 32.7087 23.324649455958248 20.3353;46.8463;24.7304 16.7643;35.8494;19.8021 25.6711;69.127;32.7087 2 497840;25698 CPS1_32421;ASS1_33159 29.39315 29.39315 3.662035309087031 22.73305 22.73305 2.4756515516122723 41.1486 41.1486 6.279815323717738 31.9826;26.8037 24.4836;20.9825 45.5891;36.7081 0 Exp 2,4(0.8);Linear,1(0.2) 1.9406579515178675 9.758840322494507 1.7569831609725952 2.371572256088257 0.24273756307594527 1.8814297914505005 21.16827039796125 39.11104960203875 17.093135134779203 30.059624865220798 27.23003718415338 56.69156281584663 UP 0.6 0.4 0.0 GO:0022900 4 electron transport chain 24 26 4 4 4 4 4 4 158 22 2363 0.97838 0.078889 0.078889 15.38 83516;29441;303612;295143 ppargc1a;por;polg2;etfdh PPARGC1A_33189;POR_9531;POLG2_9521;ETFDH_8575 34.187425 30.26625 12.4414 23.622199650946282 32.74977525289779 23.01924491963466 22.6532275 20.5839 8.48981 14.25310082869777 21.499744536880925 14.019130107536382 79.13582500000001 80.483 23.0103 44.76496878835615 80.87876186512119 39.17779019765305 0.5 15.282250000000001 1.5 30.26625 42.4094;12.4414;63.7758;18.1231 26.2988;8.48981;40.9553;14.869 81.7305;79.2355;132.567;23.0103 1 3 1 295143 ETFDH_8575 18.1231 18.1231 14.869 14.869 23.0103 23.0103 18.1231 14.869 23.0103 3 83516;29441;303612 PPARGC1A_33189;POR_9531;POLG2_9521 39.5422 42.4094 25.78702741147184 25.24797 26.2988 16.258234621314212 97.84433333333334 81.7305 30.096576908069355 42.4094;12.4414;63.7758 26.2988;8.48981;40.9553 81.7305;79.2355;132.567 0 Exp 2,2(0.5);Linear,1(0.25);Poly 2,1(0.25) 1.7585261763415503 7.060614705085754 1.5504547357559204 1.9819281101226807 0.176232099186217 1.7641159296035767 11.037669342072647 57.33718065792735 8.685188687876188 36.62126631212381 35.266155587410985 123.00549441258903 DOWN 0.25 0.75 0.0 GO:0046898 5 response to cycloheximide 7 8 3 3 3 2 2 2 160 6 2379 0.98885 0.087405 0.087405 25.0 58954;361969 klf6;fga KLF6_8969;FGA_8632 23.76395 23.76395 18.9476 6.811347491135656 25.95132632538236 6.068379047761689 17.11155 17.11155 11.6941 7.661431263478115 19.571919755923606 6.825737347222865 42.199600000000004 42.199600000000004 38.8511 4.735494113606276 40.67885719153657 4.2189556908095485 0.0 18.9476 0.0 18.9476 18.9476;28.5803 11.6941;22.529 45.5481;38.8511 0 2 0 2 58954;361969 KLF6_8969;FGA_8632 23.76395 23.76395 6.811347491135656 17.11155 17.11155 7.661431263478115 42.199600000000004 42.199600000000004 4.735494113606276 18.9476;28.5803 11.6941;22.529 45.5481;38.8511 0 Linear,1(0.5);Poly 2,1(0.5) 1.5578866510730196 3.115939140319824 1.541895866394043 1.5740432739257812 0.02273164986325963 1.557969570159912 14.323904000000002 33.203996000000004 6.493348000000003 27.729751999999998 35.63654000000001 48.76266 DOWN 0.0 1.0 0.0 GO:0050796 7 regulation of insulin secretion 45 50 6 6 6 5 5 5 157 45 2340 0.90571 0.20936 0.24555 10.0 293615;100359982;25675;113965;24957 sirt3;mpc2;hmgcr;hadh;glul SIRT3_9828;MPC2_33219;HMGCR_8810;HADH_8776;GLUL_32832 22.127354 26.4669 1.63089 19.780175424954653 26.070612667985962 18.205206236471476 16.7707654 21.0456 0.56209 15.690584469831611 19.861903664297923 14.505735194898312 33.600134000000004 35.4303 7.6286 26.138093136307393 38.5612800409283 24.215475843061423 1.5 14.42354 4.0 46.8463 2.38018;46.8463;1.63089;33.3125;26.4669 0.56209;35.8494;0.663137;25.7336;21.0456 8.82917;69.127;7.6286;46.9856;35.4303 3 2 3 293615;100359982;113965 SIRT3_9828;MPC2_33219;HADH_8776 27.512993333333338 33.3125 22.793303076696297 20.715030000000002 25.7336 18.17107854236231 41.647256666666664 46.9856 30.501319772030094 2.38018;46.8463;33.3125 0.56209;35.8494;25.7336 8.82917;69.127;46.9856 2 25675;24957 HMGCR_8810;GLUL_32832 14.048895 14.048895 17.561711088616903 10.8543685 10.8543685 14.412577804583902 21.52945 21.52945 19.658770598514042 1.63089;26.4669 0.663137;21.0456 7.6286;35.4303 0 Exp 2,1(0.2);Exp 4,1(0.2);Hill,1(0.2);Linear,2(0.4) 1.9156873919135655 9.671543836593628 1.5209722518920898 2.3622660636901855 0.29836489240604414 1.9223796129226685 4.7892657920288 39.4654422079712 3.01736171535158 30.524169084648424 10.689085202438424 56.511182797561574 UP 0.6 0.4 0.0 GO:0010827 6 regulation of glucose transmembrane transport 28 31 5 5 5 4 4 4 158 27 2358 0.95673 0.13045 0.13045 12.9 246273;29482;24890;29496 trib3;slc1a2;esr1;erbb3 TRIB3_10079;SLC1A2_33059;ESR1_33192;ERBB3_8571 51.445775 42.1978 13.3235 42.96085992795264 53.52396651160086 41.68956623171049 38.22638 29.956200000000003 9.10952 33.36909189840603 39.12285046461594 32.47603247038786 78.49822499999999 72.9438 24.6773 59.2759009886466 85.11259088794557 57.75105457740061 0.5 18.36035 2.5 84.5312 108.064;13.3235;23.3972;60.9984 83.8836;9.10952;18.3088;41.6036 143.428;24.6773;31.9156;113.972 1 3 1 29496 ERBB3_8571 60.9984 60.9984 41.6036 41.6036 113.972 113.972 60.9984 41.6036 113.972 3 246273;29482;24890 TRIB3_10079;SLC1A2_33059;ESR1_33192 48.26156666666666 23.3972 52.03477810429611 37.10064 18.3088 40.77549138760685 66.67363333333333 31.9156 66.56968415520187 108.064;13.3235;23.3972 83.8836;9.10952;18.3088 143.428;24.6773;31.9156 0 Exp 2,1(0.25);Linear,1(0.25);Poly 2,2(0.5) 1.856117928218494 7.5357420444488525 1.6013026237487793 2.436986207962036 0.38956701660178383 1.7487266063690186 9.344132270606408 93.54741772939359 5.524669939562095 70.92809006043791 20.407842031126343 136.58860796887365 DOWN 0.25 0.75 0.0 GO:0043407 9 negative regulation of MAP kinase activity 22 24 2 2 2 2 2 2 160 22 2363 0.80695 0.45749 0.66251 8.33 25675;116663 hmgcr;dusp6 HMGCR_8810;DUSP6_8506 32.012145 32.012145 1.63089 42.96558286291541 50.6577934373928 33.922277332873044 19.8753185 19.8753185 0.663137 27.170127640073474 31.666259393138937 21.45141630957948 70.4663 70.4663 7.6286 88.86592756833184 109.03118689536879 70.16161400705397 0.5 32.012145 1.63089;62.3934 0.663137;39.0875 7.6286;133.304 0 2 0 2 25675;116663 HMGCR_8810;DUSP6_8506 32.012145 32.012145 42.96558286291541 19.8753185 19.8753185 27.170127640073474 70.4663 70.4663 88.86592756833184 1.63089;62.3934 0.663137;39.0875 7.6286;133.304 0 Exp 2,1(0.5);Exp 4,1(0.5) 1.7637294149938372 3.5374785661697388 1.6357084512710571 1.9017701148986816 0.1881340065648675 1.7687392830848694 -27.535114799999995 91.55940479999998 -17.780557239999993 57.53119423999999 -52.69559199999998 193.62819199999998 DOWN 0.0 1.0 0.0 GO:1901342 6 regulation of vasculature development 120 124 8 8 7 7 6 6 156 118 2267 0.31369 0.81396 0.57482 4.84 24794;24471;24957;25112;24330;29184 serpina3c;hspb1;glul;gadd45a;egr1;cd36 SERPINA3C_32925;HSPB1_8847;GLUL_32832;GADD45A_8678;EGR1_8533;CD36_8243 49.52210283333333 38.9478 0.750017 39.294343209344625 56.60566113634342 40.68547637797385 38.65826983333333 30.44515 0.186019 31.876367769767935 44.62474513859314 33.72751001304019 61.94579666666667 54.983850000000004 4.70178 43.10929868606152 69.99099952808226 44.10396553942806 29.766;89.1011;26.4669;102.919;0.750017;48.1296 23.347;60.3265;21.0456;89.5012;0.186019;37.5433 40.8256;106.138;35.4303;115.437;4.70178;69.1421 1 5 1 29184 CD36_8243 48.1296 48.1296 37.5433 37.5433 69.1421 69.1421 48.1296 37.5433 69.1421 5 24794;24471;24957;25112;24330 SERPINA3C_32925;HSPB1_8847;GLUL_32832;GADD45A_8678;EGR1_8533 49.8006034 29.766 43.925790158800304 38.8812638 23.347 35.63362990803915 60.506536000000004 40.8256 48.03622078187958 29.766;89.1011;26.4669;102.919;0.750017 23.347;60.3265;21.0456;89.5012;0.186019 40.8256;106.138;35.4303;115.437;4.70178 0 Exp 2,1(0.17);Hill,1(0.17);Linear,2(0.34);Poly 2,2(0.34) 2.219561103471053 14.202350735664368 1.6202073097229004 4.21828556060791 1.0062598489829913 2.029791831970215 18.080079890707445 80.96412577595922 13.151863442851258 64.1646762238154 27.451173582972537 96.4404197503608 DOWN 0.16666666666666666 0.8333333333333334 0.0 GO:1902175 7 regulation of oxidative stress-induced intrinsic apoptotic signaling pathway 12 12 3 3 2 3 2 2 160 10 2375 0.96369 0.17482 0.17482 16.67 25591;24471 parp1;hspb1 PARP1_9425;HSPB1_8847 58.0376 58.0376 26.9741 43.93042299477664 56.31809290150842 43.86306709723428 41.06275 41.06275 21.799 27.243056512164717 39.99641314586035 27.201286358406048 70.70885 70.70885 35.2797 50.10438443335076 68.74768416490342 50.02756236895317 0.0 26.9741 0.5 58.0376 26.9741;89.1011 21.799;60.3265 35.2797;106.138 1 1 1 25591 PARP1_9425 26.9741 26.9741 21.799 21.799 35.2797 35.2797 26.9741 21.799 35.2797 1 24471 HSPB1_8847 89.1011 89.1011 60.3265 60.3265 106.138 106.138 89.1011 60.3265 106.138 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.7521092693167528 3.505987286567688 1.6973176002502441 1.8086696863174438 0.078737815157385 1.752993643283844 -2.8468600000000066 118.92206 3.305799999999998 78.81970000000001 1.2677160000000072 140.14998400000002 CONFLICT 0.5 0.5 0.0 GO:0030194 6 positive regulation of blood coagulation 17 18 3 3 3 3 3 3 159 15 2370 0.97609 0.10206 0.10206 16.67 85253;113936;29184 plg;cpb2;cd36 PLG_9501;CPB2_8369;CD36_8243 48.24896666666667 48.1296 25.8316 22.47728771456496 56.49327580088988 16.800248060674335 34.73876666666666 37.5433 20.4374 13.125769928782605 40.16668708565072 8.31878533306989 84.84176666666667 69.1421 34.8042 59.46268349850462 102.34167025583983 53.013751591729175 0.0 25.8316 0.5 36.9806 70.7857;25.8316;48.1296 46.2356;20.4374;37.5433 150.579;34.8042;69.1421 1 2 1 29184 CD36_8243 48.1296 48.1296 37.5433 37.5433 69.1421 69.1421 48.1296 37.5433 69.1421 2 85253;113936 PLG_9501;CPB2_8369 48.30865 48.30865 31.787348952138178 33.3365 33.3365 18.242082162406785 92.69160000000001 92.69160000000001 81.8651461705163 70.7857;25.8316 46.2356;20.4374 150.579;34.8042 0 Exp 2,2(0.67);Linear,1(0.34) 1.8534575860386158 5.7588653564453125 1.5254690647125244 2.6703107357025146 0.6503877113633116 1.5630855560302734 22.813521165859427 73.68441216747391 19.88555973532737 49.59197359800597 17.553405870452323 152.13012746288103 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0062012 5 regulation of small molecule metabolic process 117 127 21 21 17 18 14 14 148 113 2272 0.98699 0.028125 0.037826 11.02 246273;25106;192280;83516;29441;25591;246186;24360;65030;24330;140942;25428;24158;25287 trib3;rgn;ppp1r3b;ppargc1a;por;parp1;fgl1;fabp1;ephx2;egr1;ddit4;cyp7a1;acadm;acadl TRIB3_10079;RGN_9699;PPP1R3B_9545;PPARGC1A_33189;POR_9531;PARP1_9425;FGL1_8640;FABP1_33091;EPHX2_33282;EGR1_8533;DDIT4_8450;CYP7A1_8430;ACADM_7957;ACADL_32776 37.909885499999994 33.6678 0.750017 32.084591278015665 34.285954519969835 28.045558669676495 27.25587942857143 26.386200000000002 0.186019 23.751265840260718 25.132960788178398 21.210233764185656 68.17811999999999 50.27505 4.70178 62.166976960439 58.28413066206879 45.94849904562835 5.5 30.23095 11.5 82.4914 108.064;77.4407;36.1411;42.4094;12.4414;26.9741;15.4757;33.8478;38.7293;0.750017;87.5421;5.72128;11.7137;33.4878 83.8836;58.7732;27.0588;26.2988;8.48981;21.799;10.2138;26.4736;29.2097;0.186019;53.2453;0.985273;8.36151;26.6039 143.428;89.8047;53.6244;81.7305;79.2355;35.2797;30.4106;46.9257;57.2113;4.70178;245.492;22.3625;18.9642;45.3228 6 8 6 25106;25591;24360;65030;24158;25287 RGN_9699;PARP1_9425;FABP1_33091;EPHX2_33282;ACADM_7957;ACADL_32776 37.03223333333333 33.6678 21.911741205268623 28.536818333333333 26.53875 16.583882847162688 48.91806666666667 46.12425 23.835390264954057 77.4407;26.9741;33.8478;38.7293;11.7137;33.4878 58.7732;21.799;26.4736;29.2097;8.36151;26.6039 89.8047;35.2797;46.9257;57.2113;18.9642;45.3228 8 246273;192280;83516;29441;246186;24330;140942;25428 TRIB3_10079;PPP1R3B_9545;PPARGC1A_33189;POR_9531;FGL1_8640;EGR1_8533;DDIT4_8450;CYP7A1_8430 38.568124624999996 25.8084 39.59394449381016 26.29517525 18.2563 29.133289448751853 82.62316 66.42995 78.8361128277731 108.064;36.1411;42.4094;12.4414;15.4757;0.750017;87.5421;5.72128 83.8836;27.0588;26.2988;8.48981;10.2138;0.186019;53.2453;0.985273 143.428;53.6244;81.7305;79.2355;30.4106;4.70178;245.492;22.3625 0 Exp 2,5(0.36);Hill,2(0.15);Linear,2(0.15);Poly 2,5(0.36) 2.170685442768552 33.080888509750366 1.511321783065796 4.642963409423828 1.153358160221347 1.8762393593788147 21.10294878601859 54.716822213981416 14.814205529869392 39.69755332727347 35.61306600195952 100.74317399804048 CONFLICT 0.42857142857142855 0.5714285714285714 0.0 GO:0003012 4 muscle system process 68 71 4 4 3 3 2 2 160 69 2316 0.15883 0.9475 0.32056 2.82 362895;83516 stac3;ppargc1a STAC3_9953;PPARGC1A_33189 52.824349999999995 52.824349999999995 42.4094 14.728963541437698 52.658546526180174 14.727096978737487 34.50095 34.50095 26.2988 11.599591770618453 34.370373764608445 11.598121784948717 101.62525 101.62525 81.7305 28.135425270022225 101.30853041317752 28.131859741788166 63.2393;42.4094 42.7031;26.2988 121.52;81.7305 0 2 0 2 362895;83516 STAC3_9953;PPARGC1A_33189 52.824349999999995 52.824349999999995 14.728963541437698 34.50095 34.50095 11.599591770618453 101.62525 101.62525 28.135425270022225 63.2393;42.4094 42.7031;26.2988 121.52;81.7305 0 Exp 2,1(0.5);Linear,1(0.5) 2.2495470666782187 4.636773943901062 1.7576230764389038 2.879150867462158 0.7930399063217124 2.318386971950531 32.411047999999994 73.237652 18.424736000000003 50.577164 62.63154000000001 140.61896 DOWN 0.0 1.0 0.0 GO:0042060 5 wound healing 52 55 4 4 4 3 3 3 159 52 2333 0.53244 0.6909 1.0 5.45 58954;25661;24330 klf6;fn1;egr1 KLF6_8969;FN1_8655;EGR1_8533 26.425105666666667 18.9476 0.750017 30.1182484556024 33.58638784302679 32.959709080956706 14.310006333333334 11.6941 0.186019 15.597339903141188 17.75629716367235 17.08678697627046 51.83096 45.5481 4.70178 50.56421636994684 62.52509832825821 55.3701872742158 1.5 39.26265 18.9476;59.5777;0.750017 11.6941;31.0499;0.186019 45.5481;105.243;4.70178 0 3 0 3 58954;25661;24330 KLF6_8969;FN1_8655;EGR1_8533 26.425105666666667 18.9476 30.1182484556024 14.310006333333334 11.6941 15.597339903141188 51.83096 45.5481 50.56421636994684 18.9476;59.5777;0.750017 11.6941;31.0499;0.186019 45.5481;105.243;4.70178 0 Hill,1(0.34);Poly 2,1(0.34);Power,1(0.34) 2.277518271718623 7.57156240940094 1.5740432739257812 4.21828556060791 1.4710027713221032 1.7792335748672485 -7.656900885923008 60.50711221925634 -3.3400453144391555 31.960057981105823 -5.387837307800524 109.04975730780053 DOWN 0.0 1.0 0.0 GO:0043409 8 negative regulation of MAPK cascade 47 51 4 4 4 3 3 3 159 48 2337 0.59063 0.64009 1.0 5.88 293615;25675;116663 sirt3;hmgcr;dusp6 SIRT3_9828;HMGCR_8810;DUSP6_8506 22.134823333333333 2.38018 1.63089 34.86696294912181 28.109998661669252 36.47174609915421 13.437575666666666 0.663137 0.56209 22.21354353436989 17.139227541091504 23.348657493652002 49.920590000000004 8.82917 7.6286 72.21464629493313 62.232384050644484 75.6073774941809 1.5 32.38679 2.38018;1.63089;62.3934 0.56209;0.663137;39.0875 8.82917;7.6286;133.304 1 2 1 293615 SIRT3_9828 2.38018 2.38018 0.56209 0.56209 8.82917 8.82917 2.38018 0.56209 8.82917 2 25675;116663 HMGCR_8810;DUSP6_8506 32.012145 32.012145 42.96558286291541 19.8753185 19.8753185 27.170127640073474 70.4663 70.4663 88.86592756833184 1.63089;62.3934 0.663137;39.0875 7.6286;133.304 0 Exp 2,1(0.34);Exp 4,1(0.34);Hill,1(0.34) 1.6787849570473934 5.058450818061829 1.5209722518920898 1.9017701148986816 0.19534593962618232 1.6357084512710571 -17.32085953788704 61.5905062045537 -11.699415198212234 38.574566531545564 -31.79797513651399 131.63915513651398 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0007006 6 mitochondrial membrane organization 27 28 3 3 3 2 2 2 160 26 2359 0.73822 0.5404 0.6976 7.14 171139;170465 timm9;acaa2 TIMM9_10020;ACAA2_7955 171139(0.04986) 32.55315 32.55315 26.5872 8.437127402439767 27.97861142394822 5.415931354571285 25.45975 25.45975 21.3695 5.784487023496554 22.32345043149946 3.7131577071606454 45.254599999999996 45.254599999999996 35.0407 14.444635904722583 37.42284151024812 9.27225023046712 0.5 32.55315 38.5191;26.5872 29.55;21.3695 55.4685;35.0407 2 0 2 171139;170465 TIMM9_10020;ACAA2_7955 32.55315 32.55315 8.437127402439767 25.45975 25.45975 5.784487023496554 45.254599999999996 45.254599999999996 14.444635904722583 38.5191;26.5872 29.55;21.3695 55.4685;35.0407 0 0 Exp 2,2(1) 2.142890500143129 4.4540218114852905 1.620712399482727 2.8333094120025635 0.8574355703993252 2.2270109057426453 20.859887999999998 44.24641200000001 17.442859999999996 33.47664 25.235356 65.273844 UP 1.0 0.0 0.0 GO:0097192 6 extrinsic apoptotic signaling pathway in absence of ligand 22 22 2 2 2 2 2 2 160 20 2365 0.83934 0.41295 0.64706 9.09 294515;29496 foxo3;erbb3 FOXO3_8662;ERBB3_8571 37.0988 37.0988 13.1992 33.799138455292024 50.36496282649842 28.11404645442669 23.642 23.642 5.6804 25.401538321920587 33.612104529968455 21.12894177290961 73.36505 73.36505 32.7581 57.42689941660614 95.90510969085173 47.76756425515836 0.5 37.0988 13.1992;60.9984 5.6804;41.6036 32.7581;113.972 1 1 1 29496 ERBB3_8571 60.9984 60.9984 41.6036 41.6036 113.972 113.972 60.9984 41.6036 113.972 1 294515 FOXO3_8662 13.1992 13.1992 5.6804 5.6804 32.7581 32.7581 13.1992 5.6804 32.7581 0 Exp 4,1(0.5);Linear,1(0.5) 1.784358761855407 3.589643955230713 1.6013026237487793 1.9883413314819336 0.27367769481979165 1.7948219776153564 -9.744415999999994 83.942016 -11.562735999999997 58.84673599999999 -6.224571999999995 152.954672 CONFLICT 0.5 0.5 0.0 GO:0060341 5 regulation of cellular localization 248 267 16 15 12 14 11 11 151 256 2129 0.067448 0.96354 0.14327 4.12 79426;362895;25513;25591;100359982;81678;25675;81869;290556;24957;29184 zfp36;stac3;pik3r1;parp1;mpc2;itpr2;hmgcr;gstm7;gnl3;glul;cd36 ZFP36_10204;STAC3_9953;PIK3R1_32562;PARP1_9425;MPC2_33219;ITPR2_8931;HMGCR_8810;GSTM7_8761;GNL3_8735;GLUL_32832;CD36_8243 35.82996581818182 31.8111 0.348134 25.79324165916569 37.47107462702725 18.152625102774262 25.63085809090909 24.7342 0.118102 17.044210244665646 27.933041032901375 12.411131868462846 66.25243818181818 44.3296 1.15962 66.01090398071547 60.26774784123536 41.510069023001726 0.348134;63.2393;18.7324;26.9741;46.8463;31.8111;1.63089;42.3152;87.6357;26.4669;48.1296 0.118102;42.7031;11.6701;21.799;35.8494;24.7342;0.663137;31.4035;54.41;21.0456;37.5433 1.15962;121.52;41.5978;35.2797;69.127;44.3296;7.6286;64.5991;238.963;35.4303;69.1421 5 6 5 25591;100359982;81869;290556;29184 PARP1_9425;MPC2_33219;GSTM7_8761;GNL3_8735;CD36_8243 50.380179999999996 46.8463 22.463390616890422 36.20104 35.8494 11.873570262267364 95.42218 69.127 81.47580356085479 26.9741;46.8463;42.3152;87.6357;48.1296 21.799;35.8494;31.4035;54.41;37.5433 35.2797;69.127;64.5991;238.963;69.1421 6 79426;362895;25513;81678;25675;24957 ZFP36_10204;STAC3_9953;PIK3R1_32562;ITPR2_8931;HMGCR_8810;GLUL_32832 23.704787333333332 22.599649999999997 23.211351091363433 16.822373166666665 16.35785 16.229258625283247 41.94432 38.51405 42.945293884243014 0.348134;63.2393;18.7324;31.8111;1.63089;26.4669 0.118102;42.7031;11.6701;24.7342;0.663137;21.0456 1.15962;121.52;41.5978;44.3296;7.6286;35.4303 0 Exp 2,4(0.37);Exp 4,1(0.1);Hill,1(0.1);Linear,4(0.37);Poly 2,1(0.1) 1.9765742025630952 22.1564838886261 1.582527995109558 2.879150867462158 0.43141046245172127 1.9017701148986816 20.587134069780316 51.072797566583304 15.558373504564035 35.70334267725414 27.242486806420608 105.26238955721576 CONFLICT 0.45454545454545453 0.5454545454545454 0.0 GO:0080134 5 regulation of response to stress 340 358 37 36 30 31 27 27 135 331 2054 0.86453 0.19009 0.34917 7.54 79426;312688;24825;293615;25106;85253;25513;25591;25493;24539;288001;192235;65164;63868;24471;25675;29328;299626;25112;294515;361969;24890;25423;113936;114851;29184;25373 zfp36;usp18;tf;sirt3;rgn;plg;pik3r1;parp1;nfkbia;lpl;kng1;hyou1;htra1;hspd1;hspb1;hmgcr;gpx4;gadd45b;gadd45a;foxo3;fga;esr1;ctsc;cpb2;cdkn1a;cd36;ahsg ZFP36_10204;USP18_10138;TF_10003;SIRT3_9828;RGN_9699;PLG_9501;PIK3R1_32562;PARP1_9425;NFKBIA_9307;LPL_32544;KNG1L1_34113;HYOU1_8857;HTRA1_8856;HSPD1_8849;HSPB1_8847;HMGCR_8810;GPX4_32827;GADD45B_8679;GADD45A_8678;FOXO3_8662;FGA_8632;ESR1_33192;CTSC_32456;CPB2_8369;CDKN1A_8271;CD36_8243;AHSG_8003 41.679363888888886 33.1323 0.348134 33.69365206130364 47.80962867941514 31.621457419985344 28.95837337037037 23.9469 0.118102 23.650626693814647 34.1255423329852 23.906624536465685 62.32214 46.6629 1.15962 46.37072912320716 73.68964014746551 46.680826054563326 16.5 45.53715 0.348134;108.883;45.1539;2.38018;77.4407;70.7857;18.7324;26.9741;0.520151;74.2041;24.3655;40.1982;33.1323;42.2579;89.1011;1.63089;45.9204;106.367;102.919;13.1992;28.5803;23.3972;56.2386;25.8316;6.24967;48.1296;12.402 0.118102;73.1414;28.132;0.56209;58.7732;46.2356;11.6701;21.799;0.160202;49.8682;19.538;29.3844;25.6145;23.9469;60.3265;0.663137;34.2198;52.7132;89.5012;5.6804;22.529;18.3088;38.2681;20.4374;2.44025;37.5433;10.3013 1.15962;138.144;61.5341;8.82917;89.8047;150.579;41.5978;35.2797;2.88499;155.425;32.1467;62.3571;46.6629;102.383;106.138;7.6286;70.4292;109.434;115.437;32.7581;38.8511;31.9156;102.888;34.8042;19.0606;69.1421;15.4235 10 17 10 312688;24825;293615;25106;25591;24539;63868;29328;299626;29184 USP18_10138;TF_10003;SIRT3_9828;RGN_9699;PARP1_9425;LPL_32544;HSPD1_8849;GPX4_32827;GADD45B_8679;CD36_8243 57.771088 47.025000000000006 33.79806769927825 38.06990900000001 35.881550000000004 21.07437206578773 84.040497 80.11695 44.70342558444836 108.883;45.1539;2.38018;77.4407;26.9741;74.2041;42.2579;45.9204;106.367;48.1296 73.1414;28.132;0.56209;58.7732;21.799;49.8682;23.9469;34.2198;52.7132;37.5433 138.144;61.5341;8.82917;89.8047;35.2797;155.425;102.383;70.4292;109.434;69.1421 17 79426;85253;25513;25493;288001;192235;65164;24471;25675;25112;294515;361969;24890;25423;113936;114851;25373 ZFP36_10204;PLG_9501;PIK3R1_32562;NFKBIA_9307;KNG1L1_34113;HYOU1_8857;HTRA1_8856;HSPB1_8847;HMGCR_8810;GADD45A_8678;FOXO3_8662;FGA_8632;ESR1_33192;CTSC_32456;CPB2_8369;CDKN1A_8271;AHSG_8003 32.21364382352941 24.3655 30.7443074927692 23.598646529411763 19.538 24.014889991022333 49.54663588235295 34.8042 43.60998400122284 0.348134;70.7857;18.7324;0.520151;24.3655;40.1982;33.1323;89.1011;1.63089;102.919;13.1992;28.5803;23.3972;56.2386;25.8316;6.24967;12.402 0.118102;46.2356;11.6701;0.160202;19.538;29.3844;25.6145;60.3265;0.663137;89.5012;5.6804;22.529;18.3088;38.2681;20.4374;2.44025;10.3013 1.15962;150.579;41.5978;2.88499;32.1467;62.3571;46.6629;106.138;7.6286;115.437;32.7581;38.8511;31.9156;102.888;34.8042;19.0606;15.4235 0 Exp 2,9(0.34);Exp 3,1(0.04);Exp 4,4(0.15);Hill,2(0.08);Linear,4(0.15);Poly 2,5(0.19);Power,2(0.08) 1.8132140664933776 50.04657292366028 1.5209722518920898 3.431420087814331 0.4426024521898491 1.6973176002502441 28.97004501833974 54.38868275943805 20.037305520761237 37.8794412199795 44.83100007802213 79.8132799219779 DOWN 0.37037037037037035 0.6296296296296297 0.0 GO:0048856 3 anatomical structure development 699 756 70 70 50 58 41 41 121 715 1670 0.12007 0.91271 0.24776 5.42 79426;24522;308843;362895;29573;29482;246074;25106;83516;303612;85253;81819;294103;25493;24516;25685;65164;29540;24464;29328;314322;25661;246186;361969;24890;29496;25315;116636;24330;140942;25146;497840;113936;25695;114851;29184;79431;25698;65183;25373;24158 zfp36;zfp354a;tsku;stac3;slc37a4;slc1a2;scd;rgn;ppargc1a;polg2;plg;pax8;papss2;nfkbia;jun;igfbp1;htra1;hsd17b7;hp;gpx4;fos;fn1;fgl1;fga;esr1;erbb3;ephx1;eif4ebp1;egr1;ddit4;cyp17a1;cps1;cpb2;cebpd;cdkn1a;cd36;bhlhe40;ass1;aldh3a2;ahsg;acadm ZFP36_10204;ZFP354A_10203;TSKU_10094;STAC3_9953;SLC37A4_9871;SLC1A2_33059;SCD1_9787;RGN_9699;PPARGC1A_33189;POLG2_9521;PLG_9501;PAX8_9432;PAPSS2_33237;NFKBIA_9307;JUN_8938;IGFBP1_32306;HTRA1_8856;HSD17B7_8834;HP_8823;GPX4_32827;FOS_8657;FN1_8655;FGL1_8640;FGA_8632;ESR1_33192;ERBB3_8571;EPHX1_8567;EIF4EBP1_8550;EGR1_8533;DDIT4_8450;CYP17A1_32365;CPS1_32421;CPB2_8369;CEBPD_8283;CDKN1A_8271;CD36_8243;BHLHE40_8141;ASS1_33159;ALDH3A2_8024;AHSG_8003;ACADM_7957 35.79798265853661 33.1323 1.28141E-12 28.367615233634464 36.80691083623084 27.147728567610628 24.01212407804881 24.4836 1.28141E-12 18.28625524220261 24.559621126788837 17.653056750976855 68.71003878048784 46.6629 1.28142E-12 77.01829522474107 67.28483213204014 67.56994556687664 36.5 74.1132 0.348134;0.834827;1.38416;63.2393;39.7166;13.3235;105.46;77.4407;42.4094;63.7758;70.7857;56.8931;34.4443;0.520151;16.4324;49.0259;33.1323;0.977494;64.9285;45.9204;1.28141E-12;59.5777;15.4757;28.5803;23.3972;60.9984;12.4747;83.9001;0.750017;87.5421;49.6922;31.9826;25.8316;0.306936;6.24967;48.1296;57.8085;26.8037;43.1079;12.402;11.7137 0.118102;0.27095;0.540568;42.7031;22.6911;9.10952;63.7532;58.7732;26.2988;40.9553;46.2356;45.1162;25.719;0.160202;10.5224;32.6883;25.6145;0.322682;41.6103;34.2198;1.28141E-12;31.0499;10.2138;22.529;18.3088;41.6036;7.00435;42.4185;0.186019;53.2453;35.6654;24.4836;20.4374;0.0732342;2.44025;37.5433;38.3491;20.9825;31.8774;10.3013;8.36151 1.15962;2.99857;4.10872;121.52;60.0334;24.6773;422.699;89.8047;81.7305;132.567;150.579;81.5688;51.1014;2.88499;39.929;89.1623;46.6629;5.49472;136.455;70.4292;1.28142E-12;105.243;30.4106;38.8511;31.9156;113.972;23.684;107.32;4.70178;245.492;81.6409;45.5891;34.8042;1.73689;19.0606;69.1421;110.58;36.7081;66.3058;15.4235;18.9642 11 30 11 246074;25106;81819;29328;29496;25315;116636;25146;29184;65183;24158 SCD1_9787;RGN_9699;PAX8_9432;GPX4_32827;ERBB3_8571;EPHX1_8567;EIF4EBP1_8550;CYP17A1_32365;CD36_8243;ALDH3A2_8024;ACADM_7957 54.15734545454546 49.6922 28.103571866414534 36.93967818181818 37.5433 17.498973979760542 104.13915454545455 81.5688 109.69437955784575 105.46;77.4407;56.8931;45.9204;60.9984;12.4747;83.9001;49.6922;48.1296;43.1079;11.7137 63.7532;58.7732;45.1162;34.2198;41.6036;7.00435;42.4185;35.6654;37.5433;31.8774;8.36151 422.699;89.8047;81.5688;70.4292;113.972;23.684;107.32;81.6409;69.1421;66.3058;18.9642 30 79426;24522;308843;362895;29573;29482;83516;303612;85253;294103;25493;24516;25685;65164;29540;24464;314322;25661;246186;361969;24890;24330;140942;497840;113936;25695;114851;79431;25698;25373 ZFP36_10204;ZFP354A_10203;TSKU_10094;STAC3_9953;SLC37A4_9871;SLC1A2_33059;PPARGC1A_33189;POLG2_9521;PLG_9501;PAPSS2_33237;NFKBIA_9307;JUN_8938;IGFBP1_32306;HTRA1_8856;HSD17B7_8834;HP_8823;FOS_8657;FN1_8655;FGL1_8640;FGA_8632;ESR1_33192;EGR1_8533;DDIT4_8450;CPS1_32421;CPB2_8369;CEBPD_8283;CDKN1A_8271;BHLHE40_8141;ASS1_33159;AHSG_8003 29.066216300000043 26.31765 25.74646120378754 19.272020906666715 20.70995 16.401165622423473 55.71936300000004 37.7796 58.153770153060144 0.348134;0.834827;1.38416;63.2393;39.7166;13.3235;42.4094;63.7758;70.7857;34.4443;0.520151;16.4324;49.0259;33.1323;0.977494;64.9285;1.28141E-12;59.5777;15.4757;28.5803;23.3972;0.750017;87.5421;31.9826;25.8316;0.306936;6.24967;57.8085;26.8037;12.402 0.118102;0.27095;0.540568;42.7031;22.6911;9.10952;26.2988;40.9553;46.2356;25.719;0.160202;10.5224;32.6883;25.6145;0.322682;41.6103;1.28141E-12;31.0499;10.2138;22.529;18.3088;0.186019;53.2453;24.4836;20.4374;0.0732342;2.44025;38.3491;20.9825;10.3013 1.15962;2.99857;4.10872;121.52;60.0334;24.6773;81.7305;132.567;150.579;51.1014;2.88499;39.929;89.1623;46.6629;5.49472;136.455;1.28142E-12;105.243;30.4106;38.8511;31.9156;4.70178;245.492;45.5891;34.8042;1.73689;19.0606;110.58;36.7081;15.4235 0 Exp 2,15(0.37);Exp 3,1(0.03);Exp 4,3(0.08);Hill,7(0.18);Linear,8(0.2);Poly 2,6(0.15);Power,1(0.03) 1.964434369017309 84.62165904045105 1.511321783065796 4.591650485992432 0.7635747181554032 1.7576230764389038 27.11463937231997 44.48132594475324 18.414690864869968 29.60955729122766 45.13469445747747 92.28538310349816 DOWN 0.2682926829268293 0.7317073170731707 0.0 GO:0042391 4 regulation of membrane potential 94 95 5 5 5 4 4 4 158 91 2294 0.2655 0.86605 0.5201 4.21 25591;24516;170945;29184 parp1;jun;chrna2;cd36 PARP1_9425;JUN_8938;CHRNA2_32401;CD36_8243 35.23185 37.55185 16.4324 16.21163918023097 38.93444123332756 14.591170048494973 27.929275 29.67115 10.5224 14.455246513607676 31.289874609388534 12.800516814624983 51.7057 51.200500000000005 35.2797 16.617715442061623 54.46609948726831 16.746072106781284 26.9741;16.4324;49.3913;48.1296 21.799;10.5224;41.8524;37.5433 35.2797;39.929;62.472;69.1421 3 1 3 25591;170945;29184 PARP1_9425;CHRNA2_32401;CD36_8243 41.498333333333335 48.1296 12.594164806104985 33.73156666666667 37.5433 10.556121264144945 55.63126666666667 62.472 17.937732795516098 26.9741;49.3913;48.1296 21.799;41.8524;37.5433 35.2797;62.472;69.1421 1 24516 JUN_8938 16.4324 16.4324 10.5224 10.5224 39.929 39.929 16.4324 10.5224 39.929 0 Exp 2,3(0.75);Poly 2,1(0.25) 2.2148994687573147 8.976077437400818 1.8086696863174438 2.6703107357025146 0.41518701643604156 2.2485485076904297 19.344443603373648 51.119256396626355 13.763133416664488 42.09541658333552 35.4203388667796 67.9910611332204 UP 0.75 0.25 0.0 GO:0008217 4 regulation of blood pressure 48 54 7 7 5 5 3 3 159 51 2334 0.54682 0.67872 1.0 5.56 25513;65030;29184 pik3r1;ephx2;cd36 PIK3R1_32562;EPHX2_33282;CD36_8243 35.1971 38.7293 18.7324 15.013532881703767 39.77373672645741 13.184371641517671 26.141033333333336 29.2097 11.6701 13.206746605176207 30.169916412556063 11.606220278143839 55.98373333333333 57.2113 41.5978 13.813120775673175 60.317186659192835 12.597860511848607 1.5 43.42945 18.7324;38.7293;48.1296 11.6701;29.2097;37.5433 41.5978;57.2113;69.1421 2 1 2 65030;29184 EPHX2_33282;CD36_8243 43.42945 43.42945 6.6470158751879005 33.3765 33.3765 5.892745071696241 63.1767 63.1767 8.436349584980546 38.7293;48.1296 29.2097;37.5433 57.2113;69.1421 1 25513 PIK3R1_32562 18.7324 18.7324 11.6701 11.6701 41.5978 41.5978 18.7324 11.6701 41.5978 0 Exp 2,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 2.747901647049126 8.986854195594788 1.6735800504684448 4.642963409423828 1.5111843127421718 2.6703107357025146 18.207688188551625 52.18651181144837 11.196192666402718 41.085874000263956 40.35271569689326 71.61475096977341 UP 0.6666666666666666 0.3333333333333333 0.0 GO:2001234 7 negative regulation of apoptotic signaling pathway 88 93 8 8 6 7 5 5 157 88 2297 0.45181 0.71695 0.8309 5.38 192235;24471;361969;246142;170465 hyou1;hspb1;fga;bmf;acaa2 HYOU1_8857;HSPB1_8847;FGA_8632;BMF_8152;ACAA2_7955 55.868700000000004 40.1982 26.5872 33.44265263409888 57.62009183883459 35.24223097750094 41.34872 29.3844 21.3695 23.806348514146393 43.03411454062984 25.366922887968727 70.44698 62.3571 35.0407 35.85958637696481 70.96505071349274 38.27507180807701 3.5 91.9889 40.1982;89.1011;28.5803;94.8767;26.5872 29.3844;60.3265;22.529;73.1342;21.3695 62.3571;106.138;38.8511;109.848;35.0407 2 3 2 246142;170465 BMF_8152;ACAA2_7955 60.73195 60.73195 48.28796853383874 47.251850000000005 47.251850000000005 36.60317039608728 72.44435 72.44435 52.8967491122564 94.8767;26.5872 73.1342;21.3695 109.848;35.0407 3 192235;24471;361969 HYOU1_8857;HSPB1_8847;FGA_8632 52.626533333333334 40.1982 32.11758724193543 37.4133 29.3844 20.13728328176371 69.11540000000001 62.3571 34.1487582800605 40.1982;89.1011;28.5803 29.3844;60.3265;22.529 62.3571;106.138;38.8511 0 Exp 2,2(0.4);Linear,1(0.2);Poly 2,2(0.4) 1.835604845554198 9.425792217254639 1.541895866394043 2.8333094120025635 0.5339177580451496 1.6973176002502441 26.554922501999073 85.18247749800094 20.481535479116488 62.21590452088353 39.01466666870388 101.87929333129614 DOWN 0.4 0.6 0.0 GO:0006928 3 movement of cell or subcellular component 248 268 12 12 7 11 7 7 155 261 2124 0.0029334 0.99901 0.0051931 2.61 29573;85253;25493;494344;24471;25661;140942 slc37a4;plg;nfkbia;ier2;hspb1;fn1;ddit4 SLC37A4_9871;PLG_9501;NFKBIA_9307;IER2_32643;HSPB1_8847;FN1_8655;DDIT4_8450 56.70353585714286 59.5777 0.520151 30.826467207760498 60.61338267368176 21.345315874847472 35.310171714285715 33.4626 0.160202 20.343611892165736 37.51496663994401 15.397413411181109 108.54439857142857 105.243 2.88499 75.74126308733359 106.04623373915072 48.07864378618174 39.7166;70.7857;0.520151;49.6814;89.1011;59.5777;87.5421 22.6911;46.2356;0.160202;33.4626;60.3265;31.0499;53.2453 60.0334;150.579;2.88499;89.4404;106.138;105.243;245.492 0 7 0 7 29573;85253;25493;494344;24471;25661;140942 SLC37A4_9871;PLG_9501;NFKBIA_9307;IER2_32643;HSPB1_8847;FN1_8655;DDIT4_8450 56.70353585714286 59.5777 30.826467207760498 35.310171714285715 33.4626 20.343611892165736 108.54439857142857 105.243 75.74126308733359 39.7166;70.7857;0.520151;49.6814;89.1011;59.5777;87.5421 22.6911;46.2356;0.160202;33.4626;60.3265;31.0499;53.2453 60.0334;150.579;2.88499;89.4404;106.138;105.243;245.492 0 Exp 2,1(0.15);Exp 4,1(0.15);Linear,2(0.29);Poly 2,2(0.29);Power,1(0.15) 1.7364411973682792 12.182216048240662 1.5254690647125244 1.893584966659546 0.12384040657945057 1.7647881507873535 33.866969368624716 79.54010234566101 20.239413120349433 50.380930308221984 52.434485659228315 164.65431148362882 DOWN 0.0 1.0 0.0 GO:0006704 6 glucocorticoid biosynthetic process 2 3 1 1 1 1 1 1 161 2 2383 0.98844 0.179 0.179 33.33 25146 cyp17a1 CYP17A1_32365 49.6922 49.6922 49.6922 49.6922 35.6654 35.6654 35.6654 35.6654 81.6409 81.6409 81.6409 81.6409 0.0 49.6922 0.0 49.6922 49.6922 35.6654 81.6409 1 0 1 25146 CYP17A1_32365 49.6922 49.6922 35.6654 35.6654 81.6409 81.6409 49.6922 35.6654 81.6409 0 0 Linear,1(1) 1.90940523147583 1.90940523147583 1.90940523147583 1.90940523147583 0.0 1.90940523147583 49.6922 49.6922 35.6654 35.6654 81.6409 81.6409 UP 1.0 0.0 0.0 GO:0030856 6 regulation of epithelial cell differentiation 50 51 6 6 4 4 2 2 160 49 2336 0.35991 0.84641 0.76928 3.92 79426;81819 zfp36;pax8 ZFP36_10204;PAX8_9432 28.620617 28.620617 0.348134 39.98332890056277 44.53345653405529 33.04889810413341 22.617151 22.617151 0.118102 31.818460236296822 35.28048008948418 26.300087538859067 41.36421 41.36421 1.15962 56.85787644764971 63.992897731547444 46.99684135378066 0.348134;56.8931 0.118102;45.1162 1.15962;81.5688 1 1 1 81819 PAX8_9432 56.8931 56.8931 45.1162 45.1162 81.5688 81.5688 56.8931 45.1162 81.5688 1 79426 ZFP36_10204 0.348134 0.348134 0.118102 0.118102 1.15962 1.15962 0.348134 0.118102 1.15962 0 Exp 2,1(0.5);Hill,1(0.5) 1.8428426335895582 3.690374493598938 1.7521979808807373 1.9381765127182007 0.13150668101738858 1.845187246799469 -26.79344968 84.03468368 -21.480985039999993 66.71528703999999 -37.436786399999995 120.16520639999999 CONFLICT 0.5 0.5 0.0 GO:0009895 6 negative regulation of catabolic process 80 83 11 11 9 9 7 7 155 76 2309 0.84599 0.27385 0.3657 8.43 79426;25106;83516;24464;25675;140942;246142 zfp36;rgn;ppargc1a;hp;hmgcr;ddit4;bmf ZFP36_10204;RGN_9699;PPARGC1A_33189;HP_8823;HMGCR_8810;DDIT4_8450;BMF_8152 52.739489142857146 64.9285 0.348134 39.177250640576325 66.44400658891449 30.811204161403374 36.26329128571429 41.6103 0.118102 28.449592270526598 47.20366326056655 24.638279126993375 96.01691714285714 89.8047 1.15962 82.88790882723923 105.13956252938891 54.59184312266442 3.5 71.1846 0.348134;77.4407;42.4094;64.9285;1.63089;87.5421;94.8767 0.118102;58.7732;26.2988;41.6103;0.663137;53.2453;73.1342 1.15962;89.8047;81.7305;136.455;7.6286;245.492;109.848 2 5 2 25106;246142 RGN_9699;BMF_8152 86.15870000000001 86.15870000000001 12.329113836768547 65.9537 65.9537 10.154760484620116 99.82634999999999 99.82634999999999 14.172753347356458 77.4407;94.8767 58.7732;73.1342 89.8047;109.848 5 79426;83516;24464;25675;140942 ZFP36_10204;PPARGC1A_33189;HP_8823;HMGCR_8810;DDIT4_8450 39.3718048 42.4094 38.503157423929345 24.3871278 26.2988 23.90031174857092 94.493144 81.7305 101.21873919972862 0.348134;42.4094;64.9285;1.63089;87.5421 0.118102;26.2988;41.6103;0.663137;53.2453 1.15962;81.7305;136.455;7.6286;245.492 0 Exp 2,2(0.29);Exp 4,1(0.15);Hill,1(0.15);Linear,1(0.15);Poly 2,2(0.29) 1.7566926123818394 12.319473505020142 1.6336230039596558 1.9381765127182007 0.11654778108112553 1.7198865413665771 23.7165757139181 81.76240257179619 15.187538391994625 57.339044179433955 34.61269497655742 157.42113930915684 DOWN 0.2857142857142857 0.7142857142857143 0.0 GO:0071051 11 polyadenylation-dependent snoRNA 3'-end processing 2 2 1 1 1 1 1 1 161 1 2384 0.99598 0.12319 0.12319 50.0 308441 exosc5 EXOSC5_32543 41.9329 41.9329 41.9329 41.9329 31.7336 31.7336 31.7336 31.7336 62.1373 62.1373 62.1373 62.1373 0.0 41.9329 0.0 41.9329 41.9329 31.7336 62.1373 1 0 1 308441 EXOSC5_32543 41.9329 41.9329 31.7336 31.7336 62.1373 62.1373 41.9329 31.7336 62.1373 0 0 Exp 2,1(1) 1.5979743003845215 1.5979743003845215 1.5979743003845215 1.5979743003845215 0.0 1.5979743003845215 41.9329 41.9329 31.7336 31.7336 62.1373 62.1373 UP 1.0 0.0 0.0 GO:0006814 8 sodium ion transport 24 25 3 2 1 3 1 1 161 24 2361 0.52098 0.80814 1.0 4.0 29500 slc10a2 SLC10A2_9833 56.585 56.585 56.585 56.585 35.2796 35.2796 35.2796 35.2796 116.8 116.8 116.8 116.8 56.585 35.2796 116.8 0 1 0 1 29500 SLC10A2_9833 56.585 56.585 35.2796 35.2796 116.8 116.8 56.585 35.2796 116.8 0 Exp 2,1(1) 1.5972119569778442 1.5972119569778442 1.5972119569778442 1.5972119569778442 0.0 1.5972119569778442 56.585 56.585 35.2796 35.2796 116.8 116.8 DOWN 0.0 1.0 0.0 GO:0046700 5 heterocycle catabolic process 52 63 5 5 4 4 3 3 159 60 2325 0.42324 0.77611 0.7956 4.76 79426;24443;308441 zfp36;hdc;exosc5 ZFP36_10204;HDC_8788;EXOSC5_32543 22.285178000000002 24.5745 0.348134 20.886692826616947 16.870336537906926 21.68141536887418 17.637867333333332 21.0619 0.118102 16.083467543530574 13.28408195368145 16.854628420801404 30.858973333333335 29.28 1.15962 30.51948938196925 23.613978505571335 31.074911911066643 0.348134;24.5745;41.9329 0.118102;21.0619;31.7336 1.15962;29.28;62.1373 2 1 2 24443;308441 HDC_8788;EXOSC5_32543 33.253699999999995 33.253699999999995 12.274242350548594 26.397750000000002 26.397750000000002 7.546031436788461 45.708650000000006 45.708650000000006 23.23361964148074 24.5745;41.9329 21.0619;31.7336 29.28;62.1373 1 79426 ZFP36_10204 0.348134 0.348134 0.118102 0.118102 1.15962 1.15962 0.348134 0.118102 1.15962 0 Exp 2,2(0.67);Hill,1(0.34) 3.7853708049108516 21.049216151237488 1.5979743003845215 17.513065338134766 9.091965520990136 1.9381765127182007 -1.3503399428195095 45.920695942819506 -0.5622895255562348 35.8380241922229 -3.677080070678006 65.39502673734468 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0050790 4 regulation of catalytic activity 528 565 50 50 43 46 39 39 123 526 1859 0.75942 0.3041 0.55789 6.9 79426;246273;24825;29573;293615;79224;24794;24648;25106;252922;192280;29441;303612;25513;25591;24314;299282;288001;24516;54404;50693;306251;63868;24471;24464;25675;29455;299626;25112;25661;83928;24360;24890;29496;24330;116663;114851;25377;25373 zfp36;trib3;tf;slc37a4;sirt3;serpind1;serpina3c;serpina1;rgn;pzp;ppp1r3b;por;polg2;pik3r1;parp1;nqo1;loc299282;kng1;jun;itih4;itih3;itih1;hspd1;hspb1;hp;hmgcr;gdf15;gadd45b;gadd45a;fn1;fetub;fabp1;esr1;erbb3;egr1;dusp6;cdkn1a;ambp;ahsg ZFP36_10204;TRIB3_10079;TF_10003;SLC37A4_9871;SIRT3_9828;SERPIND1_9812;SERPINA3C_32925;SERPINA1_9807;RGN_9699;PZP_9633;PPP1R3B_9545;POR_9531;POLG2_9521;PIK3R1_32562;PARP1_9425;NQO1_33055;LOC299282_9119;KNG1L1_34113;JUN_8938;ITIH4_32725;ITIH3_32422;ITIH1_33132;HSPD1_8849;HSPB1_8847;HP_8823;HMGCR_8810;GDF15_33113;GADD45B_8679;GADD45A_8678;FN1_8655;FETUB_33027;FABP1_33091;ESR1_33192;ERBB3_8571;EGR1_8533;DUSP6_8506;CDKN1A_8271;AMBP_33085;AHSG_8003 44.01512797435898 34.1871 0.348134 32.81561276926006 47.99298221564139 31.921043754988922 30.05043866666667 23.9469 0.118102 23.253071286676313 32.555860816900775 23.817486998794852 68.99377102564101 53.6244 1.15962 47.704656667365676 74.33000903119778 42.2387975080953 27.5 61.695899999999995 0.348134;108.064;45.1539;39.7166;2.38018;28.261;29.766;15.797;77.4407;34.1871;36.1411;12.4414;63.7758;18.7324;26.9741;87.2765;45.2017;24.3655;16.4324;57.1163;27.1247;98.1741;42.2579;89.1011;64.9285;1.63089;105.149;106.367;102.919;59.5777;32.5155;33.8478;23.3972;60.9984;0.750017;62.3934;6.24967;17.2343;12.402 0.118102;83.8836;28.132;22.6911;0.56209;22.307;23.347;13.013;58.7732;26.3085;27.0588;8.48981;40.9553;11.6701;21.799;60.6992;30.7472;19.538;10.5224;39.6402;21.5108;42.9071;23.9469;60.3265;41.6103;0.663137;85.3487;52.7132;89.5012;31.0499;19.6094;26.4736;18.3088;41.6036;0.186019;39.0875;2.44025;14.1233;10.3013 1.15962;143.428;61.5341;60.0334;8.82917;38.3264;40.8256;19.9134;89.8047;48.5666;53.6244;79.2355;132.567;41.5978;35.2797;197.117;78.6415;32.1467;39.929;101.869;36.4819;104.278;102.383;106.138;136.455;7.6286;125.652;109.434;115.437;105.243;49.9875;46.9257;31.9156;113.972;4.70178;133.304;19.0606;21.9073;15.4235 9 30 9 24825;293615;25106;25591;24314;63868;299626;24360;29496 TF_10003;SIRT3_9828;RGN_9699;PARP1_9425;NQO1_33055;HSPD1_8849;GADD45B_8679;FABP1_33091;ERBB3_8571 53.632942222222226 45.1539 32.52711604894514 34.966976666666675 28.132 19.9538375944115 85.03104111111111 89.8047 55.459747054072565 45.1539;2.38018;77.4407;26.9741;87.2765;42.2579;106.367;33.8478;60.9984 28.132;0.56209;58.7732;21.799;60.6992;23.9469;52.7132;26.4736;41.6036 61.5341;8.82917;89.8047;35.2797;197.117;102.383;109.434;46.9257;113.972 30 79426;246273;29573;79224;24794;24648;252922;192280;29441;303612;25513;299282;288001;24516;54404;50693;306251;24471;24464;25675;29455;25112;25661;83928;24890;24330;116663;114851;25377;25373 ZFP36_10204;TRIB3_10079;SLC37A4_9871;SERPIND1_9812;SERPINA3C_32925;SERPINA1_9807;PZP_9633;PPP1R3B_9545;POR_9531;POLG2_9521;PIK3R1_32562;LOC299282_9119;KNG1L1_34113;JUN_8938;ITIH4_32725;ITIH3_32422;ITIH1_33132;HSPB1_8847;HP_8823;HMGCR_8810;GDF15_33113;GADD45A_8678;FN1_8655;FETUB_33027;ESR1_33192;EGR1_8533;DUSP6_8506;CDKN1A_8271;AMBP_33085;AHSG_8003 41.1297837 31.14075 32.89191549382753 28.575477266666667 22.499049999999997 24.267717165954863 64.18258999999999 49.27705 45.05263728211464 0.348134;108.064;39.7166;28.261;29.766;15.797;34.1871;36.1411;12.4414;63.7758;18.7324;45.2017;24.3655;16.4324;57.1163;27.1247;98.1741;89.1011;64.9285;1.63089;105.149;102.919;59.5777;32.5155;23.3972;0.750017;62.3934;6.24967;17.2343;12.402 0.118102;83.8836;22.6911;22.307;23.347;13.013;26.3085;27.0588;8.48981;40.9553;11.6701;30.7472;19.538;10.5224;39.6402;21.5108;42.9071;60.3265;41.6103;0.663137;85.3487;89.5012;31.0499;19.6094;18.3088;0.186019;39.0875;2.44025;14.1233;10.3013 1.15962;143.428;60.0334;38.3264;40.8256;19.9134;48.5666;53.6244;79.2355;132.567;41.5978;78.6415;32.1467;39.929;101.869;36.4819;104.278;106.138;136.455;7.6286;125.652;115.437;105.243;49.9875;31.9156;4.70178;133.304;19.0606;21.9073;15.4235 0 Exp 2,12(0.31);Exp 3,2(0.06);Exp 4,2(0.06);Hill,3(0.08);Linear,7(0.18);Poly 2,11(0.29);Power,2(0.06) 1.8525822707714714 74.34228265285492 1.5197933912277222 4.21828556060791 0.5443235122730486 1.7033517360687256 33.71590913645943 54.31434681225852 22.75243477081688 37.34844256251643 54.02160816954143 83.9659338817406 DOWN 0.23076923076923078 0.7692307692307693 0.0 GO:0045807 6 positive regulation of endocytosis 32 34 2 2 2 2 2 2 160 32 2353 0.63122 0.64759 1.0 5.88 24825;29184 tf;cd36 TF_10003;CD36_8243 46.64175 46.64175 45.1539 2.1041376487768804 46.820067348222715 2.0889712998614876 32.837650000000004 32.837650000000004 28.132 6.654794049780926 33.40161748977666 6.60682716483108 65.3381 65.3381 61.5341 5.379668391267444 65.79400563070148 5.340892445255782 0.5 46.64175 45.1539;48.1296 28.132;37.5433 61.5341;69.1421 2 0 2 24825;29184 TF_10003;CD36_8243 46.64175 46.64175 2.1041376487768804 32.837650000000004 32.837650000000004 6.654794049780926 65.3381 65.3381 5.379668391267444 45.1539;48.1296 28.132;37.5433 61.5341;69.1421 0 0 Exp 2,1(0.5);Poly 2,1(0.5) 2.213279966119726 4.50478196144104 1.8344712257385254 2.6703107357025146 0.5910277854791777 2.25239098072052 43.725564 49.557936000000005 23.614576000000007 42.060724 57.88226 72.79393999999999 UP 1.0 0.0 0.0 GO:0032966 7 negative regulation of collagen biosynthetic process 9 9 3 3 3 3 3 3 159 6 2379 0.99846 0.01596 0.01596 33.33 25661;25428;65210 fn1;cyp7a1;cyp2j4 FN1_8655;CYP7A1_8430;CYP2J4_32580 27.71282666666667 17.8395 5.72128 28.253148999786436 39.75580054776583 26.61596705646773 15.561757666666667 14.6501 0.985273 15.053032549562108 22.745113492225435 11.68675793116153 50.07346666666666 22.6149 22.3625 47.77838405182131 67.3787505155764 50.440501798161506 0.0 5.72128 0.0 5.72128 59.5777;5.72128;17.8395 31.0499;0.985273;14.6501 105.243;22.3625;22.6149 1 2 1 65210 CYP2J4_32580 17.8395 17.8395 14.6501 14.6501 22.6149 22.6149 17.8395 14.6501 22.6149 2 25661;25428 FN1_8655;CYP7A1_8430 32.64949 32.64949 38.082239792430805 16.0175865 16.0175865 21.258901625544173 63.802749999999996 63.802749999999996 58.605363578131644 59.5777;5.72128 31.0499;0.985273 105.243;22.3625 0 Hill,1(0.34);Linear,1(0.34);Power,1(0.34) 3.137915667194177 10.147542595863342 1.7792335748672485 4.560328960418701 1.43853702964211 3.8079800605773926 -4.25862116707669 59.68427450041003 -1.4723522267687041 32.595867560102036 -3.9928646051114782 104.1397979384448 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0034121 7 regulation of toll-like receptor signaling pathway 15 16 2 2 2 2 2 2 160 14 2371 0.92323 0.27077 0.27077 12.5 24890;29184 esr1;cd36 ESR1_33192;CD36_8243 35.763400000000004 35.763400000000004 23.3972 17.48844775501815 44.1356925570002 12.870712472897406 27.926050000000004 27.926050000000004 18.3088 13.600845382732643 34.43722001130583 10.00961164545071 50.52885 50.52885 31.9156 26.323110589841033 63.13058492557 19.37262772202938 0.0 23.3972 0.5 35.763400000000004 23.3972;48.1296 18.3088;37.5433 31.9156;69.1421 1 1 1 29184 CD36_8243 48.1296 48.1296 37.5433 37.5433 69.1421 69.1421 48.1296 37.5433 69.1421 1 24890 ESR1_33192 23.3972 23.3972 18.3088 18.3088 31.9156 31.9156 23.3972 18.3088 31.9156 0 Exp 2,2(1) 2.5509822488367075 5.107296943664551 2.436986207962036 2.6703107357025146 0.16498535578244108 2.5536484718322754 11.525648 60.001152000000005 9.076240000000002 46.77586000000001 14.046880000000009 87.01082 CONFLICT 0.5 0.5 0.0 GO:0032870 5 cellular response to hormone stimulus 198 212 43 42 31 37 27 27 135 185 2200 0.9999 2.5064E-4 3.1689E-4 12.74 79426;286954;246273;24825;83516;29441;24651;25513;81819;25591;24516;294515;314322;25661;24890;29496;25315;116636;24330;140942;25146;497840;29184;25698;25373;312382;25303 zfp36;ugt2b1;trib3;tf;ppargc1a;por;pklr;pik3r1;pax8;parp1;jun;foxo3;fos;fn1;esr1;erbb3;ephx1;eif4ebp1;egr1;ddit4;cyp17a1;cps1;cd36;ass1;ahsg;abcg2;abcc2 ZFP36_10204;UGT2B10_33303,UGT2B1_33224;TRIB3_10079;TF_10003;PPARGC1A_33189;POR_9531;PKLR_9489;PIK3R1_32562;PAX8_9432;PARP1_9425;JUN_8938;FOXO3_8662;FOS_8657;FN1_8655;ESR1_33192;ERBB3_8571;EPHX1_8567;EIF4EBP1_8550;EGR1_8533;DDIT4_8450;CYP17A1_32365;CPS1_32421;CD36_8243;ASS1_33159;AHSG_8003;ABCG2_32656;ABCC2_32541 35.56726818518523 26.9741 1.28141E-12 28.13656801622998 37.31216863577491 26.149174663544425 24.100263370370417 21.799 1.28141E-12 19.352819696226913 25.200588393596842 17.81960313700366 62.28307592592597 45.5891 1.28142E-12 52.3260873788626 62.35105592854781 42.6040062109868 9.5 20.91435 20.5 53.292649999999995 0.348134;47.47345;108.064;45.1539;42.4094;12.4414;23.0963;18.7324;56.8931;26.9741;16.4324;13.1992;1.28141E-12;59.5777;23.3972;60.9984;12.4747;83.9001;0.750017;87.5421;49.6922;31.9826;48.1296;26.8037;12.402;5.21654;46.2316 0.118102;34.82915;83.8836;28.132;26.2988;8.48981;17.4625;11.6701;45.1162;21.799;10.5224;5.6804;1.28141E-12;31.0499;18.3088;41.6036;7.00435;42.4185;0.186019;53.2453;35.6654;24.4836;37.5433;20.9825;10.3013;2.73368;31.1788 1.15962;76.47475;143.428;61.5341;81.7305;79.2355;32.9443;41.5978;81.5688;35.2797;39.929;32.7581;1.28142E-12;105.243;31.9156;113.972;23.684;107.32;4.70178;245.492;81.6409;45.5891;69.1421;36.7081;15.4235;11.386;81.7848 11 17 10 286954;24825;81819;25591;29496;25315;116636;25146;29184;312382 UGT2B10_33303,UGT2B1_33224;TF_10003;PAX8_9432;PARP1_9425;ERBB3_8571;EPHX1_8567;EIF4EBP1_8550;CYP17A1_32365;CD36_8243;ABCG2_32656 43.690609 47.801525 23.32612279030454 29.684518000000004 35.247275 14.801214892944722 66.20023499999999 72.808425 33.91474057851254 47.47345;45.1539;56.8931;26.9741;60.9984;12.4747;83.9001;49.6922;48.1296;5.21654 34.82915;28.132;45.1162;21.799;41.6036;7.00435;42.4185;35.6654;37.5433;2.73368 76.47475;61.5341;81.5688;35.2797;113.972;23.684;107.32;81.6409;69.1421;11.386 17 79426;246273;83516;29441;24651;25513;24516;294515;314322;25661;24890;24330;140942;497840;25698;25373;25303 ZFP36_10204;TRIB3_10079;PPARGC1A_33189;POR_9531;PKLR_9489;PIK3R1_32562;JUN_8938;FOXO3_8662;FOS_8657;FN1_8655;ESR1_33192;EGR1_8533;DDIT4_8450;CPS1_32421;ASS1_33159;AHSG_8003;ABCC2_32541 30.788832411764783 23.0963 30.247211265820344 20.81540770588243 17.4625 21.317341857761903 59.97886470588242 39.929 61.539071583787056 0.348134;108.064;42.4094;12.4414;23.0963;18.7324;16.4324;13.1992;1.28141E-12;59.5777;23.3972;0.750017;87.5421;31.9826;26.8037;12.402;46.2316 0.118102;83.8836;26.2988;8.48981;17.4625;11.6701;10.5224;5.6804;1.28141E-12;31.0499;18.3088;0.186019;53.2453;24.4836;20.9825;10.3013;31.1788 1.15962;143.428;81.7305;79.2355;32.9443;41.5978;39.929;32.7581;1.28142E-12;105.243;31.9156;4.70178;245.492;45.5891;36.7081;15.4235;81.7848 0 Exp 2,12(0.43);Exp 3,1(0.04);Exp 4,2(0.08);Hill,4(0.15);Linear,3(0.11);Poly 2,5(0.18);Power,1(0.04) 1.9929295434281078 57.50570452213287 1.5074360370635986 4.21828556060791 0.5917369864197216 1.8680511713027954 24.9540935079334 46.180442862437054 16.80033767172308 31.400189069017753 42.545561911826184 82.02058994002577 DOWN 0.37037037037037035 0.6296296296296297 0.0 GO:0030098 5 lymphocyte differentiation 53 58 4 4 2 3 2 2 160 56 2329 0.27462 0.89351 0.58234 3.45 25513;24330 pik3r1;egr1 PIK3R1_32562;EGR1_8533 9.741208499999999 9.741208499999999 0.750017 12.715464961193689 6.85490368086439 12.042488869059154 5.9280595 5.9280595 0.186019 8.120471550795587 4.0847799783902285 7.690689138023237 23.14979 23.14979 4.70178 26.089425940794484 17.227707240839337 24.708622331232956 18.7324;0.750017 11.6701;0.186019 41.5978;4.70178 0 2 0 2 25513;24330 PIK3R1_32562;EGR1_8533 9.741208499999999 9.741208499999999 12.715464961193689 5.9280595 5.9280595 8.120471550795587 23.14979 23.14979 26.089425940794484 18.7324;0.750017 11.6701;0.186019 41.5978;4.70178 0 Hill,1(0.5);Poly 2,1(0.5) 2.656998035643327 5.891865611076355 1.6735800504684448 4.21828556060791 1.7993785223423886 2.9459328055381775 -7.881526839999999 27.363943839999997 -5.326339879999997 17.18245888 -13.0083096 59.307889599999996 DOWN 0.0 1.0 0.0 GO:0009064 8 glutamine family amino acid metabolic process 23 24 4 4 3 4 3 3 159 21 2364 0.93819 0.19305 0.19305 12.5 24957;497840;25698 glul;cps1;ass1 GLUL_32832;CPS1_32421;ASS1_33159 28.417733333333334 26.8037 26.4669 3.0918545119932483 28.59665390275112 3.1421984246673946 22.17056666666667 21.0456 20.9825 2.003394070903995 22.274648394113882 2.0474018098166287 39.2425 36.7081 35.4303 5.533325571480474 39.589955252719136 5.594063361740447 0.5 26.6353 1.5 29.39315 26.4669;31.9826;26.8037 21.0456;24.4836;20.9825 35.4303;45.5891;36.7081 0 3 0 3 24957;497840;25698 GLUL_32832;CPS1_32421;ASS1_33159 28.417733333333334 26.8037 3.0918545119932483 22.17056666666667 21.0456 2.003394070903995 39.2425 36.7081 5.533325571480474 26.4669;31.9826;26.8037 21.0456;24.4836;20.9825 35.4303;45.5891;36.7081 0 Exp 2,2(0.67);Linear,1(0.34) 2.0097570444613186 6.070171356201172 1.8264755010604858 2.3622660636901855 0.29475838176849095 1.8814297914505005 24.91897058513613 31.91649608153054 19.903512858653183 24.437620474680156 32.98095266391211 45.504047336087886 DOWN 0.0 1.0 0.0 GO:0031960 6 response to corticosteroid 128 142 29 29 21 27 19 19 143 123 2262 0.99953 0.0012403 0.0019951 13.38 79426;286954;25513;25591;63868;24464;294515;314322;25661;25315;116636;140942;497840;81718;114851;25698;24158;312382;25303 zfp36;ugt2b1;pik3r1;parp1;hspd1;hp;foxo3;fos;fn1;ephx1;eif4ebp1;ddit4;cps1;cdo1;cdkn1a;ass1;acadm;abcg2;abcc2 ZFP36_10204;UGT2B10_33303,UGT2B1_33224;PIK3R1_32562;PARP1_9425;HSPD1_8849;HP_8823;FOXO3_8662;FOS_8657;FN1_8655;EPHX1_8567;EIF4EBP1_8550;DDIT4_8450;CPS1_32421;CDO1_8275;CDKN1A_8271;ASS1_33159;ACADM_7957;ABCG2_32656;ABCC2_32541 32.0299944210527 26.8037 1.28141E-12 26.908273486084248 33.6099329845358 25.204522952996705 20.108775894736908 20.9825 1.28141E-12 15.92380880270538 21.087787362170605 14.626218868964173 60.59777210526323 36.7081 1.28142E-12 59.870038708490135 59.683883558511745 48.8676256480762 6.5 15.965799999999998 13.5 46.852525 0.348134;47.47345;18.7324;26.9741;42.2579;64.9285;13.1992;1.28141E-12;59.5777;12.4747;83.9001;87.5421;31.9826;22.9638;6.24967;26.8037;11.7137;5.21654;46.2316 0.118102;34.82915;11.6701;21.799;23.9469;41.6103;5.6804;1.28141E-12;31.0499;7.00435;42.4185;53.2453;24.4836;18.5144;2.44025;20.9825;8.36151;2.73368;31.1788 1.15962;76.47475;41.5978;35.2797;102.383;136.455;32.7581;1.28142E-12;105.243;23.684;107.32;245.492;45.5891;30.0179;19.0606;36.7081;18.9642;11.386;81.7848 8 12 7 286954;25591;63868;25315;116636;24158;312382 UGT2B10_33303,UGT2B1_33224;PARP1_9425;HSPD1_8849;EPHX1_8567;EIF4EBP1_8550;ACADM_7957;ABCG2_32656 32.85864142857143 26.9741 27.593768619515302 20.156155714285713 21.799 14.964423004121983 53.641664285714285 35.2797 40.82712009376359 47.47345;26.9741;42.2579;12.4747;83.9001;11.7137;5.21654 34.82915;21.799;23.9469;7.00435;42.4185;8.36151;2.73368 76.47475;35.2797;102.383;23.684;107.32;18.9642;11.386 12 79426;25513;24464;294515;314322;25661;140942;497840;81718;114851;25698;25303 ZFP36_10204;PIK3R1_32562;HP_8823;FOXO3_8662;FOS_8657;FN1_8655;DDIT4_8450;CPS1_32421;CDO1_8275;CDKN1A_8271;ASS1_33159;ABCC2_32541 31.546617000000108 24.88375 27.727384626450743 20.081137666666773 19.74845 17.11084118505901 64.65550166666678 39.152950000000004 70.05333755984157 0.348134;18.7324;64.9285;13.1992;1.28141E-12;59.5777;87.5421;31.9826;22.9638;6.24967;26.8037;46.2316 0.118102;11.6701;41.6103;5.6804;1.28141E-12;31.0499;53.2453;24.4836;18.5144;2.44025;20.9825;31.1788 1.15962;41.5978;136.455;32.7581;1.28142E-12;105.243;245.492;45.5891;30.0179;19.0606;36.7081;81.7848 0 Exp 2,7(0.35);Exp 3,2(0.1);Exp 4,3(0.15);Hill,3(0.15);Linear,2(0.1);Poly 2,2(0.1);Power,1(0.05) 1.8105844919768583 36.46897351741791 1.5074360370635986 2.4453113079071045 0.23009186205904683 1.7939516305923462 19.9305590554131 44.1294297866923 12.948558221062067 27.26899356841176 33.67691952561549 87.51862468491093 DOWN 0.3684210526315789 0.631578947368421 0.0 GO:0045923 7 positive regulation of fatty acid metabolic process 25 26 4 4 3 4 3 3 159 23 2362 0.92111 0.2269 0.2269 11.54 25106;83516;24360 rgn;ppargc1a;fabp1 RGN_9699;PPARGC1A_33189;FABP1_33091 51.23263333333333 42.4094 33.8478 23.097019665821236 50.76891566823122 22.882401656520457 37.18186666666667 26.4736 26.2988 18.698847426869218 36.788899135375495 18.522006588874657 72.8203 81.7305 46.9257 22.785870803636193 72.56405072875495 22.788787629657538 0.5 38.1286 1.5 59.92505 77.4407;42.4094;33.8478 58.7732;26.2988;26.4736 89.8047;81.7305;46.9257 2 1 2 25106;24360 RGN_9699;FABP1_33091 55.64425 55.64425 30.824835201587067 42.623400000000004 42.623400000000004 22.839266189613 68.3652 68.3652 30.32003167049796 77.4407;33.8478 58.7732;26.4736 89.8047;46.9257 1 83516 PPARGC1A_33189 42.4094 42.4094 26.2988 26.2988 81.7305 81.7305 42.4094 26.2988 81.7305 0 Exp 2,2(0.67);Poly 2,1(0.34) 1.7830713109458534 5.35285210609436 1.7198865413665771 1.8753424882888794 0.08108478837928312 1.7576230764389038 25.095895111114974 77.3693715555517 16.022128859606852 58.34160447372648 47.035659861289204 98.6049401387108 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0001932 8 regulation of protein phosphorylation 371 395 31 31 25 28 22 22 140 373 2012 0.2832 0.78963 0.57473 5.57 246273;24825;293615;25106;83516;25513;24516;24471;25675;29455;299626;25112;25661;361969;24890;29496;24330;116663;140942;114851;29184;25373 trib3;tf;sirt3;rgn;ppargc1a;pik3r1;jun;hspb1;hmgcr;gdf15;gadd45b;gadd45a;fn1;fga;esr1;erbb3;egr1;dusp6;ddit4;cdkn1a;cd36;ahsg TRIB3_10079;TF_10003;SIRT3_9828;RGN_9699;PPARGC1A_33189;PIK3R1_32562;JUN_8938;HSPB1_8847;HMGCR_8810;GDF15_33113;GADD45B_8679;GADD45A_8678;FN1_8655;FGA_8632;ESR1_33192;ERBB3_8571;EGR1_8533;DUSP6_8506;DDIT4_8450;CDKN1A_8271;CD36_8243;AHSG_8003 50.26365259090908 46.64175 0.750017 37.89873746495073 51.783749883137475 36.07762691373248 34.75863163636364 29.59095 0.186019 28.2648482615577 36.894779887729065 28.827216820249774 77.64766136363636 75.4363 4.70178 58.680437684313446 76.38418190278387 48.892918377637585 18.5 104.03399999999999 108.064;45.1539;2.38018;77.4407;42.4094;18.7324;16.4324;89.1011;1.63089;105.149;106.367;102.919;59.5777;28.5803;23.3972;60.9984;0.750017;62.3934;87.5421;6.24967;48.1296;12.402 83.8836;28.132;0.56209;58.7732;26.2988;11.6701;10.5224;60.3265;0.663137;85.3487;52.7132;89.5012;31.0499;22.529;18.3088;41.6036;0.186019;39.0875;53.2453;2.44025;37.5433;10.3013 143.428;61.5341;8.82917;89.8047;81.7305;41.5978;39.929;106.138;7.6286;125.652;109.434;115.437;105.243;38.8511;31.9156;113.972;4.70178;133.304;245.492;19.0606;69.1421;15.4235 6 16 6 24825;293615;25106;299626;29496;29184 TF_10003;SIRT3_9828;RGN_9699;GADD45B_8679;ERBB3_8571;CD36_8243 56.74496333333334 54.564 34.85070634591021 36.554565000000004 39.57345 20.725044923776405 75.45267833333332 79.4734 38.772905421590686 45.1539;2.38018;77.4407;106.367;60.9984;48.1296 28.132;0.56209;58.7732;52.7132;41.6036;37.5433 61.5341;8.82917;89.8047;109.434;113.972;69.1421 16 246273;83516;25513;24516;24471;25675;29455;25112;25661;361969;24890;24330;116663;140942;114851;25373 TRIB3_10079;PPARGC1A_33189;PIK3R1_32562;JUN_8938;HSPB1_8847;HMGCR_8810;GDF15_33113;GADD45A_8678;FN1_8655;FGA_8632;ESR1_33192;EGR1_8533;DUSP6_8506;DDIT4_8450;CDKN1A_8271;AHSG_8003 47.8331610625 35.49485 39.7854083028642 34.085156625 24.413899999999998 31.201162157232886 78.47078 61.66415000000001 65.70379493731139 108.064;42.4094;18.7324;16.4324;89.1011;1.63089;105.149;102.919;59.5777;28.5803;23.3972;0.750017;62.3934;87.5421;6.24967;12.402 83.8836;26.2988;11.6701;10.5224;60.3265;0.663137;85.3487;89.5012;31.0499;22.529;18.3088;0.186019;39.0875;53.2453;2.44025;10.3013 143.428;81.7305;41.5978;39.929;106.138;7.6286;125.652;115.437;105.243;38.8511;31.9156;4.70178;133.304;245.492;19.0606;15.4235 0 Exp 2,5(0.23);Exp 4,2(0.1);Hill,2(0.1);Linear,3(0.14);Poly 2,8(0.37);Power,2(0.1) 1.885822377212614 43.213021874427795 1.5209722518920898 4.21828556060791 0.6766804698065323 1.7086020708084106 34.42677815696769 66.10052702485045 22.947503278152038 46.56975999457522 53.12666711693784 102.16865561033485 DOWN 0.2727272727272727 0.7272727272727273 0.0 GO:0031334 7 positive regulation of protein-containing complex assembly 61 68 3 3 3 3 3 3 159 65 2320 0.36173 0.81894 0.79887 4.41 24890;29184;246142 esr1;cd36;bmf ESR1_33192;CD36_8243;BMF_8152 55.46783333333334 48.1296 23.3972 36.300371642771545 68.18863989098118 32.0661279522349 42.995433333333345 37.5433 18.3088 27.816369995082628 52.7808924876115 24.48581120644995 70.3019 69.1421 31.9156 38.979143069980374 85.2762138949455 31.052895865083634 23.3972;48.1296;94.8767 18.3088;37.5433;73.1342 31.9156;69.1421;109.848 2 1 2 29184;246142 CD36_8243;BMF_8152 71.50315 71.50315 33.05519141080562 55.338750000000005 55.338750000000005 25.16656673853229 89.49504999999999 89.49504999999999 28.783417924301535 48.1296;94.8767 37.5433;73.1342 69.1421;109.848 1 24890 ESR1_33192 23.3972 23.3972 18.3088 18.3088 31.9156 31.9156 23.3972 18.3088 31.9156 0 Exp 2,2(0.67);Poly 2,1(0.34) 2.228716625561502 6.808474659919739 1.701177716255188 2.6703107357025146 0.5058117701767981 2.436986207962036 14.390095827643606 96.54557083902306 11.518247472436528 74.47261919423015 26.192847261301154 114.41095273869885 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0034308 5 primary alcohol metabolic process 18 22 5 5 3 5 3 3 159 19 2366 0.95308 0.16066 0.16066 13.64 24856;360268;65183 ttr;sult1e1;aldh3a2 TTR_10102;SULT1E1_32446;ALDH3A2_8024 46.64436666666668 46.6406 43.1079 3.538351503642973 46.24978439479637 3.349495320996681 32.32196666666667 31.8774 28.5876 3.9753375785375873 31.746704507918547 3.7814211703407294 70.33306666666667 66.3058 63.7146 9.31006487696694 68.95257578054299 8.597621002547065 0.5 44.87425 1.5 48.4126 46.6406;50.1846;43.1079 28.5876;36.5009;31.8774 63.7146;80.9788;66.3058 3 0 3 24856;360268;65183 TTR_10102;SULT1E1_32446;ALDH3A2_8024 46.64436666666668 46.6406 3.538351503642973 32.32196666666667 31.8774 3.9753375785375873 70.33306666666667 66.3058 9.31006487696694 46.6406;50.1846;43.1079 28.5876;36.5009;31.8774 63.7146;80.9788;66.3058 0 0 Exp 2,1(0.34);Linear,1(0.34);Poly 2,1(0.34) 1.7204851721208405 5.185441493988037 1.520427942276001 1.9248499870300293 0.20246399212242497 1.7401635646820068 42.640345008159585 50.64838832517374 27.82344871333354 36.820484619999796 59.79773647940277 80.86839685393056 UP 1.0 0.0 0.0 GO:0009066 8 aspartate family amino acid metabolic process 14 14 3 3 2 3 2 2 160 12 2373 0.94527 0.22236 0.22236 14.29 25698;296925 ass1;aass ASS1_33159;AASS_7936 27.134050000000002 27.134050000000002 26.8037 0.467185450329471 27.148295993208826 0.46675084183645865 21.36615 21.36615 20.9825 0.54256303320439 21.382694499151103 0.5420583032254656 36.8688 36.8688 36.7081 0.22726411947281597 36.87573001697793 0.2270527025370327 0.0 26.8037 0.5 27.134050000000002 26.8037;27.4644 20.9825;21.7498 36.7081;37.0295 1 1 1 296925 AASS_7936 27.4644 27.4644 21.7498 21.7498 37.0295 37.0295 27.4644 21.7498 37.0295 1 25698 ASS1_33159 26.8037 26.8037 20.9825 20.9825 36.7081 36.7081 26.8037 20.9825 36.7081 0 Exp 2,1(0.5);Linear,1(0.5) 1.9049731860780106 3.8102409839630127 1.8814297914505005 1.9288111925125122 0.03350370999306797 1.9051204919815063 26.486564 27.781536000000003 20.614196000000003 22.118104 36.553828 37.183772 CONFLICT 0.5 0.5 0.0 GO:2001233 6 regulation of apoptotic signaling pathway 139 145 12 12 10 10 8 8 154 137 2248 0.41701 0.71688 0.86044 5.52 25591;192235;24471;289388;361969;25423;246142;170465 parp1;hyou1;hspb1;g0s2;fga;ctsc;bmf;acaa2 PARP1_9425;HYOU1_8857;HSPB1_8847;G0S2_32729;FGA_8632;CTSC_32456;BMF_8152;ACAA2_7955 51.116825000000006 43.2883 26.5872 27.302804832248576 52.55835258687818 29.802089168639743 37.5752625 31.5879 21.3695 19.279344696624158 38.91961378823274 21.328739501101737 70.5069375 68.005 35.0407 32.60816345110695 70.56960860180004 35.53276620181325 6.5 91.9889 26.9741;40.1982;89.1011;46.3784;28.5803;56.2386;94.8767;26.5872 21.799;29.3844;60.3265;33.7914;22.529;38.2681;73.1342;21.3695 35.2797;62.3571;106.138;73.6529;38.8511;102.888;109.848;35.0407 4 4 4 25591;289388;246142;170465 PARP1_9425;G0S2_32729;BMF_8152;ACAA2_7955 48.7041 36.676249999999996 32.138595887499505 37.52352500000001 27.7952 24.42854983516554 63.455325 54.466300000000004 35.8586465052596 26.9741;46.3784;94.8767;26.5872 21.799;33.7914;73.1342;21.3695 35.2797;73.6529;109.848;35.0407 4 192235;24471;361969;25423 HYOU1_8857;HSPB1_8847;FGA_8632;CTSC_32456 53.52955 48.2184 26.28601713008903 37.627 33.82625 16.44757700716633 77.55855 82.62255 32.597120359575754 40.1982;89.1011;28.5803;56.2386 29.3844;60.3265;22.529;38.2681 62.3571;106.138;38.8511;102.888 0 Exp 2,4(0.5);Linear,2(0.25);Poly 2,2(0.25) 1.847189192863775 15.093333959579468 1.541895866394043 2.8333094120025635 0.4477253582454392 1.699247658252716 32.19694652655009 70.03670347344989 24.215358235620478 50.935166764379524 47.91063307164928 93.10324192835071 CONFLICT 0.5 0.5 0.0 GO:0045595 5 regulation of cell differentiation 433 456 31 31 23 25 19 19 143 437 1948 0.018496 0.98986 0.03399 4.17 79426;246273;24825;360268;29441;25513;81819;25591;25493;24539;24516;24471;29455;294515;314322;25661;25695;29184;79431 zfp36;trib3;tf;sult1e1;por;pik3r1;pax8;parp1;nfkbia;lpl;jun;hspb1;gdf15;foxo3;fos;fn1;cebpd;cd36;bhlhe40 ZFP36_10204;TRIB3_10079;TF_10003;SULT1E1_32446;POR_9531;PIK3R1_32562;PAX8_9432;PARP1_9425;NFKBIA_9307;LPL_32544;JUN_8938;HSPB1_8847;GDF15_33113;FOXO3_8662;FOS_8657;FN1_8655;CEBPD_8283;CD36_8243;BHLHE40_8141 41.2221221578948 45.1539 1.28141E-12 35.412952707915615 49.55004719409586 32.830647373961035 29.19113937894744 28.132 1.28141E-12 26.963551799188906 35.067080947969494 25.12324752314984 67.06691578947375 69.1421 1.28142E-12 49.06702154189586 79.17538121152027 45.556671063982 0.348134;108.064;45.1539;50.1846;12.4414;18.7324;56.8931;26.9741;0.520151;74.2041;16.4324;89.1011;105.149;13.1992;1.28141E-12;59.5777;0.306936;48.1296;57.8085 0.118102;83.8836;28.132;36.5009;8.48981;11.6701;45.1162;21.799;0.160202;49.8682;10.5224;60.3265;85.3487;5.6804;1.28141E-12;31.0499;0.0732342;37.5433;38.3491 1.15962;143.428;61.5341;80.9788;79.2355;41.5978;81.5688;35.2797;2.88499;155.425;39.929;106.138;125.652;32.7581;1.28142E-12;105.243;1.73689;69.1421;110.58 6 13 6 24825;360268;81819;25591;24539;29184 TF_10003;SULT1E1_32446;PAX8_9432;PARP1_9425;LPL_32544;CD36_8243 50.256566666666664 49.1571 15.428334680277928 36.49326666666666 37.0221 10.394024267369547 80.65474999999999 75.06045 40.36970723157405 45.1539;50.1846;56.8931;26.9741;74.2041;48.1296 28.132;36.5009;45.1162;21.799;49.8682;37.5433 61.5341;80.9788;81.5688;35.2797;155.425;69.1421 13 79426;246273;29441;25513;25493;24516;24471;29455;294515;314322;25661;25695;79431 ZFP36_10204;TRIB3_10079;POR_9531;PIK3R1_32562;NFKBIA_9307;JUN_8938;HSPB1_8847;GDF15_33113;FOXO3_8662;FOS_8657;FN1_8655;CEBPD_8283;BHLHE40_8141 37.05237853846164 16.4324 41.50046924059611 25.82092678461548 10.5224 31.726477970935683 60.7956076923078 41.5978 52.89036155467874 0.348134;108.064;12.4414;18.7324;0.520151;16.4324;89.1011;105.149;13.1992;1.28141E-12;59.5777;0.306936;57.8085 0.118102;83.8836;8.48981;11.6701;0.160202;10.5224;60.3265;85.3487;5.6804;1.28141E-12;31.0499;0.0732342;38.3491 1.15962;143.428;79.2355;41.5978;2.88499;39.929;106.138;125.652;32.7581;1.28142E-12;105.243;1.73689;110.58 0 Exp 2,6(0.32);Exp 4,2(0.11);Hill,3(0.16);Poly 2,7(0.37);Power,1(0.06) 1.8248962422555217 34.92275428771973 1.559399127960205 2.6703107357025146 0.24221013749807022 1.8086696863174438 25.298516631235287 57.145727684554316 17.06684785236249 41.31543090553238 45.003692147955405 89.13013943099207 DOWN 0.3157894736842105 0.6842105263157895 0.0 GO:0051336 5 regulation of hydrolase activity 294 317 28 28 23 25 20 20 142 297 2088 0.5437 0.55425 1.0 6.31 79224;24794;24648;25106;252922;192280;29441;299282;288001;24516;54404;50693;306251;63868;25661;83928;24360;24890;25377;25373 serpind1;serpina3c;serpina1;rgn;pzp;ppp1r3b;por;loc299282;kng1;jun;itih4;itih3;itih1;hspd1;fn1;fetub;fabp1;esr1;ambp;ahsg SERPIND1_9812;SERPINA3C_32925;SERPINA1_9807;RGN_9699;PZP_9633;PPP1R3B_9545;POR_9531;LOC299282_9119;KNG1L1_34113;JUN_8938;ITIH4_32725;ITIH3_32422;ITIH1_33132;HSPD1_8849;FN1_8655;FETUB_33027;FABP1_33091;ESR1_33192;AMBP_33085;AHSG_8003 36.18407 31.14075 12.402 22.30740550789781 42.943028773368454 23.759308619049467 24.398810500000003 22.826999999999998 8.48981 12.21154817142556 27.27205809650646 12.349383030986806 56.871415 47.74615 15.4235 30.61851170665903 68.98279212106704 30.003044125732288 14.5 43.7298 28.261;29.766;15.797;77.4407;34.1871;36.1411;12.4414;45.2017;24.3655;16.4324;57.1163;27.1247;98.1741;42.2579;59.5777;32.5155;33.8478;23.3972;17.2343;12.402 22.307;23.347;13.013;58.7732;26.3085;27.0588;8.48981;30.7472;19.538;10.5224;39.6402;21.5108;42.9071;23.9469;31.0499;19.6094;26.4736;18.3088;14.1233;10.3013 38.3264;40.8256;19.9134;89.8047;48.5666;53.6244;79.2355;78.6415;32.1467;39.929;101.869;36.4819;104.278;102.383;105.243;49.9875;46.9257;31.9156;21.9073;15.4235 3 17 3 25106;63868;24360 RGN_9699;HSPD1_8849;FABP1_33091 51.18213333333333 42.2579 23.126104039447146 36.3979 26.4736 19.418717537211357 79.70446666666668 89.8047 29.075575073647812 77.4407;42.2579;33.8478 58.7732;23.9469;26.4736 89.8047;102.383;46.9257 17 79224;24794;24648;252922;192280;29441;299282;288001;24516;54404;50693;306251;25661;83928;24890;25377;25373 SERPIND1_9812;SERPINA3C_32925;SERPINA1_9807;PZP_9633;PPP1R3B_9545;POR_9531;LOC299282_9119;KNG1L1_34113;JUN_8938;ITIH4_32725;ITIH3_32422;ITIH1_33132;FN1_8655;FETUB_33027;ESR1_33192;AMBP_33085;AHSG_8003 33.53735294117647 28.261 21.781931290381415 22.28132411764706 21.5108 9.908913008625783 52.842052941176476 40.8256 29.876350545103342 28.261;29.766;15.797;34.1871;36.1411;12.4414;45.2017;24.3655;16.4324;57.1163;27.1247;98.1741;59.5777;32.5155;23.3972;17.2343;12.402 22.307;23.347;13.013;26.3085;27.0588;8.48981;30.7472;19.538;10.5224;39.6402;21.5108;42.9071;31.0499;19.6094;18.3088;14.1233;10.3013 38.3264;40.8256;19.9134;48.5666;53.6244;79.2355;78.6415;32.1467;39.929;101.869;36.4819;104.278;105.243;49.9875;31.9156;21.9073;15.4235 0 Exp 2,7(0.35);Exp 3,2(0.1);Linear,6(0.3);Poly 2,4(0.2);Power,1(0.05) 1.9374993380396355 39.71109986305237 1.5197933912277222 3.431420087814331 0.49112453524051064 1.827288031578064 26.407418477006715 45.960721522993296 19.04686354292312 29.75075745707688 43.452260584991315 70.29056941500869 DOWN 0.15 0.85 0.0 GO:0016053 5 organic acid biosynthetic process 89 96 21 21 15 17 11 11 151 85 2300 0.9832 0.038509 0.051026 11.46 65192;246074;25106;24651;24539;24957;25428;81718;25698;25284;296925 slc27a2;scd;rgn;pklr;lpl;glul;cyp7a1;cdo1;ass1;amacr;aass SLC27A2_9860;SCD1_9787;RGN_9699;PKLR_9489;LPL_32544;GLUL_32832;CYP7A1_8430;CDO1_8275;ASS1_33159;AMACR_8038;AASS_7936 36.298255454545455 26.4669 2.03774 33.853962029473415 38.05987816492138 32.028235245457346 25.436257545454545 20.9825 0.985273 22.19254106781038 27.099480643439176 20.88369763076183 79.95911 35.4303 3.73641 121.33506684187182 77.33354372857671 107.43130126131413 3.5 23.03005 8.5 75.8224 7.62189;105.46;77.4407;23.0963;74.2041;26.4669;5.72128;22.9638;26.8037;2.03774;27.4644 5.49916;63.7532;58.7732;17.4625;49.8682;21.0456;0.985273;18.5144;20.9825;1.165;21.7498 13.3925;422.699;89.8047;32.9443;155.425;35.4303;22.3625;30.0179;36.7081;3.73641;37.0295 6 5 6 65192;246074;25106;24539;25284;296925 SLC27A2_9860;SCD1_9787;RGN_9699;LPL_32544;AMACR_8038;AASS_7936 49.038138333333336 50.83425 42.45757144478445 33.468093333333336 35.809 27.530234569481365 120.34785166666666 63.4171 158.46711371738056 7.62189;105.46;77.4407;74.2041;2.03774;27.4644 5.49916;63.7532;58.7732;49.8682;1.165;21.7498 13.3925;422.699;89.8047;155.425;3.73641;37.0295 5 24651;24957;25428;81718;25698 PKLR_9489;GLUL_32832;CYP7A1_8430;CDO1_8275;ASS1_33159 21.010395999999997 23.0963 8.735840799320927 15.7980546 18.5144 8.425891887236972 31.49262 32.9443 5.708498500656734 23.0963;26.4669;5.72128;22.9638;26.8037 17.4625;21.0456;0.985273;18.5144;20.9825 32.9443;35.4303;22.3625;30.0179;36.7081 0 Exp 2,4(0.37);Exp 4,1(0.1);Hill,2(0.19);Linear,3(0.28);Poly 2,1(0.1) 2.141158866848049 24.701589584350586 1.559399127960205 4.560328960418701 0.8415567091257681 2.008971929550171 16.291842377394943 56.30466853169598 12.321303867427165 38.55121122348193 8.254667670065828 151.66355232993416 CONFLICT 0.5454545454545454 0.45454545454545453 0.0 GO:0018130 5 heterocycle biosynthetic process 162 180 22 22 16 19 14 14 148 166 2219 0.83429 0.25053 0.42658 7.78 298490;303612;24651;81819;294103;100359982;24516;24443;294515;314322;24890;24330;497840;25028 ppcs;polg2;pklr;pax8;papss2;mpc2;jun;hdc;foxo3;fos;esr1;egr1;cps1;ampd1 PPCS_9540;POLG2_9521;PKLR_9489;PAX8_9432;PAPSS2_33237;MPC2_33219;JUN_8938;HDC_8788;FOXO3_8662;FOS_8657;ESR1_33192;EGR1_8533;CPS1_32421;AMPD1_32743 29.759394071428662 23.98585 1.28141E-12 20.684089275855193 34.0336524160587 22.28969072771934 22.29807992857152 19.68535 1.28141E-12 15.961957074689188 25.924978879274246 17.502261133181054 47.12969142857152 36.43665 1.28142E-12 34.79798897059034 52.6610362309146 35.65269420754524 8.0 31.9826 20.3353;63.7758;23.0963;56.8931;34.4443;46.8463;16.4324;24.5745;13.1992;1.28141E-12;23.3972;0.750017;31.9826;60.9045 16.7643;40.9553;17.4625;45.1162;25.719;35.8494;10.5224;21.0619;5.6804;1.28141E-12;18.3088;0.186019;24.4836;50.0633 25.6711;132.567;32.9443;81.5688;51.1014;69.127;39.929;29.28;32.7581;1.28142E-12;31.9156;4.70178;45.5891;82.6625 5 9 5 298490;81819;100359982;24443;25028 PPCS_9540;PAX8_9432;MPC2_33219;HDC_8788;AMPD1_32743 41.91074 46.8463 18.54480123344547 33.77102 35.8494 14.570701909894392 57.66188 69.127 28.093424133718553 20.3353;56.8931;46.8463;24.5745;60.9045 16.7643;45.1162;35.8494;21.0619;50.0633 25.6711;81.5688;69.127;29.28;82.6625 9 303612;24651;294103;24516;294515;314322;24890;24330;497840 POLG2_9521;PKLR_9489;PAPSS2_33237;JUN_8938;FOXO3_8662;FOS_8657;ESR1_33192;EGR1_8533;CPS1_32421 23.008646333333477 23.0963 19.486348213199502 15.924224333333475 17.4625 13.412659389376287 41.2784755555557 32.9443 38.27854005458365 63.7758;23.0963;34.4443;16.4324;13.1992;1.28141E-12;23.3972;0.750017;31.9826 40.9553;17.4625;25.719;10.5224;5.6804;1.28141E-12;18.3088;0.186019;24.4836 132.567;32.9443;51.1014;39.929;32.7581;1.28142E-12;31.9156;4.70178;45.5891 0 Exp 2,10(0.72);Exp 4,1(0.08);Hill,2(0.15);Poly 2,1(0.08) 2.4172794394074697 45.529165506362915 1.5504547357559204 17.513065338134766 4.1600167336568195 1.9504427313804626 18.924405511551328 40.59438263130599 13.936695485148404 30.65946437199463 28.90139008183526 65.35799277530776 DOWN 0.35714285714285715 0.6428571428571429 0.0 GO:0009968 6 negative regulation of signal transduction 284 297 27 27 22 25 20 20 142 277 2108 0.66658 0.4279 0.79996 6.73 308843;293615;25493;192235;65164;24471;25675;81869;29455;294515;361969;24890;29496;24330;116663;140942;65210;246142;25373;170465 tsku;sirt3;nfkbia;hyou1;htra1;hspb1;hmgcr;gstm7;gdf15;foxo3;fga;esr1;erbb3;egr1;dusp6;ddit4;cyp2j4;bmf;ahsg;acaa2 TSKU_10094;SIRT3_9828;NFKBIA_9307;HYOU1_8857;HTRA1_8856;HSPB1_8847;HMGCR_8810;GSTM7_8761;GDF15_33113;FOXO3_8662;FGA_8632;ESR1_33192;ERBB3_8571;EGR1_8533;DUSP6_8506;DDIT4_8450;CYP2J4_32580;BMF_8152;AHSG_8003;ACAA2_7955 37.2188599 27.583750000000002 0.520151 34.64261823188055 44.475796023610286 35.2751985974319 26.704965800000004 21.94925 0.160202 25.404324999648203 32.89568525539836 26.584657818428152 60.639112999999995 36.9459 2.88499 61.81668675646033 64.36563901013447 51.73510410318677 13.5 51.6568 1.38416;2.38018;0.520151;40.1982;33.1323;89.1011;1.63089;42.3152;105.149;13.1992;28.5803;23.3972;60.9984;0.750017;62.3934;87.5421;17.8395;94.8767;12.402;26.5872 0.540568;0.56209;0.160202;29.3844;25.6145;60.3265;0.663137;31.4035;85.3487;5.6804;22.529;18.3088;41.6036;0.186019;39.0875;53.2453;14.6501;73.1342;10.3013;21.3695 4.10872;8.82917;2.88499;62.3571;46.6629;106.138;7.6286;64.5991;125.652;32.7581;38.8511;31.9156;113.972;4.70178;133.304;245.492;22.6149;109.848;15.4235;35.0407 6 14 6 293615;81869;29496;65210;246142;170465 SIRT3_9828;GSTM7_8761;ERBB3_8571;CYP2J4_32580;BMF_8152;ACAA2_7955 40.83286333333333 34.4512 33.28610824178859 30.453831666666662 26.386499999999998 25.18980857882046 59.150645 49.819900000000004 44.84125196000386 2.38018;42.3152;60.9984;17.8395;94.8767;26.5872 0.56209;31.4035;41.6036;14.6501;73.1342;21.3695 8.82917;64.5991;113.972;22.6149;109.848;35.0407 14 308843;25493;192235;65164;24471;25675;29455;294515;361969;24890;24330;116663;140942;25373 TSKU_10094;NFKBIA_9307;HYOU1_8857;HTRA1_8856;HSPB1_8847;HMGCR_8810;GDF15_33113;FOXO3_8662;FGA_8632;ESR1_33192;EGR1_8533;DUSP6_8506;DDIT4_8450;AHSG_8003 35.67000128571429 25.988750000000003 36.32156844379083 25.098309 20.4189 26.26656217021034 61.277027857142855 35.8046 69.35531301573971 1.38416;0.520151;40.1982;33.1323;89.1011;1.63089;105.149;13.1992;28.5803;23.3972;0.750017;62.3934;87.5421;12.402 0.540568;0.160202;29.3844;25.6145;60.3265;0.663137;85.3487;5.6804;22.529;18.3088;0.186019;39.0875;53.2453;10.3013 4.10872;2.88499;62.3571;46.6629;106.138;7.6286;125.652;32.7581;38.8511;31.9156;4.70178;133.304;245.492;15.4235 0 Exp 2,5(0.25);Exp 4,3(0.15);Hill,3(0.15);Linear,6(0.3);Poly 2,3(0.15) 2.046027731848068 43.335866808891296 1.5209722518920898 4.21828556060791 0.8316247563394452 1.7256652116775513 22.036063040128532 52.401656759871464 15.571029466144697 37.8389021338553 33.546755508673755 87.7314704913262 DOWN 0.3 0.7 0.0 GO:0043470 6 regulation of carbohydrate catabolic process 24 25 6 6 5 4 3 3 159 22 2363 0.92992 0.20982 0.20982 12.0 192280;83516;140942 ppp1r3b;ppargc1a;ddit4 PPP1R3B_9545;PPARGC1A_33189;DDIT4_8450 55.364200000000004 42.4094 36.1411 28.042571788799968 44.30755357406043 19.640754058798823 35.5343 27.0588 26.2988 15.342882413353747 29.879099742078115 10.452882691868187 126.94896666666666 81.7305 53.6244 103.61865796372452 85.70375755342668 73.1334519098809 0.5 39.27525 1.5 64.97575 36.1411;42.4094;87.5421 27.0588;26.2988;53.2453 53.6244;81.7305;245.492 0 3 0 3 192280;83516;140942 PPP1R3B_9545;PPARGC1A_33189;DDIT4_8450 55.364200000000004 42.4094 28.042571788799968 35.5343 27.0588 15.342882413353747 126.94896666666666 81.7305 103.61865796372452 36.1411;42.4094;87.5421 27.0588;26.2988;53.2453 53.6244;81.7305;245.492 0 Exp 2,2(0.67);Linear,1(0.34) 1.766108610223366 5.304738402366638 1.6672165393829346 1.8798987865447998 0.10673833229146108 1.7576230764389038 23.631042712775184 87.09735728722481 18.172194108670652 52.89640589132935 9.693416932555408 244.20451640077795 DOWN 0.0 1.0 0.0 GO:0071466 5 cellular response to xenobiotic stimulus 51 53 13 13 10 11 8 8 154 45 2340 0.99466 0.017089 0.017089 15.09 83516;81869;116636;24330;140942;25698;312382;25303 ppargc1a;gstm7;eif4ebp1;egr1;ddit4;ass1;abcg2;abcc2 PPARGC1A_33189;GSTM7_8761;EIF4EBP1_8550;EGR1_8533;DDIT4_8450;ASS1_33159;ABCG2_32656;ABCC2_32541 41.896082125 42.3623 0.750017 31.922450272370863 35.70909229394873 31.349317613810758 26.055887374999998 28.738799999999998 0.186019 18.129747291364964 21.90869474559929 17.5022965928203 79.215285 73.16480000000001 4.70178 76.18053523592924 60.17705995144045 58.113726896727194 1.5 16.01012 4.5 44.320499999999996 42.4094;42.3152;83.9001;0.750017;87.5421;26.8037;5.21654;46.2316 26.2988;31.4035;42.4185;0.186019;53.2453;20.9825;2.73368;31.1788 81.7305;64.5991;107.32;4.70178;245.492;36.7081;11.386;81.7848 3 5 3 81869;116636;312382 GSTM7_8761;EIF4EBP1_8550;ABCG2_32656 43.81061333333333 42.3152 39.36308993646882 25.518559999999997 31.4035 20.48647416494113 61.101699999999994 64.5991 48.06253160279846 42.3152;83.9001;5.21654 31.4035;42.4185;2.73368 64.5991;107.32;11.386 5 83516;24330;140942;25698;25303 PPARGC1A_33189;EGR1_8533;DDIT4_8450;ASS1_33159;ABCC2_32541 40.7473634 42.4094 31.68911508018957 26.3782838 26.2988 19.10521559104771 90.083436 81.7305 92.77582435397422 42.4094;0.750017;87.5421;26.8037;46.2316 26.2988;0.186019;53.2453;20.9825;31.1788 81.7305;4.70178;245.492;36.7081;81.7848 0 Exp 2,3(0.38);Exp 3,1(0.13);Exp 4,1(0.13);Hill,1(0.13);Linear,2(0.25) 1.9278499377231877 16.313962697982788 1.5074360370635986 4.21828556060791 0.8883353841061427 1.7538878917694092 19.77495268650989 64.01721156349011 13.492613469095849 38.61916128090415 26.42486740144865 132.00570259855135 DOWN 0.375 0.625 0.0 GO:0072511 7 divalent inorganic cation transport 59 63 4 4 4 2 2 2 160 61 2324 0.22389 0.91857 0.4325 3.17 81678;25303 itpr2;abcc2 ITPR2_8931;ABCC2_32541 39.02135 39.02135 31.8111 10.19683333810061 36.51322015905947 9.560019849716188 27.9565 27.9565 24.7342 4.557020362034837 26.835603112033194 4.272424945284925 63.0572 63.0572 44.3296 26.484825910698376 56.54268907330567 24.830793348017725 31.8111;46.2316 24.7342;31.1788 44.3296;81.7848 0 2 0 2 81678;25303 ITPR2_8931;ABCC2_32541 39.02135 39.02135 10.19683333810061 27.9565 27.9565 4.557020362034837 63.0572 63.0572 26.484825910698376 31.8111;46.2316 24.7342;31.1788 44.3296;81.7848 0 Exp 2,1(0.5);Linear,1(0.5) 1.7606320288524313 3.526465654373169 1.6674995422363281 1.8589661121368408 0.13538730994718065 1.7632328271865845 24.88926 53.153439999999996 21.640792 34.27220799999999 26.351104 99.763296 DOWN 0.0 1.0 0.0 GO:0051180 5 vitamin transport 12 14 4 4 3 4 3 3 159 11 2374 0.99046 0.054735 0.054735 21.43 25351;24384;312382 slc2a2;gc;abcg2 SLC2A2_9863;GC_32893;ABCG2_32656 25.776013333333335 29.7555 5.21654 18.886823657527316 24.496344260806016 21.042688128565928 17.481926666666666 23.3399 2.73368 12.862029218911509 15.797457032783463 13.868145571716328 43.65076666666667 40.808 11.386 33.775992858291126 43.961956561912714 37.87005615662054 0.0 5.21654 0.5 17.48602 29.7555;42.356;5.21654 23.3399;26.3722;2.73368 40.808;78.7583;11.386 1 2 1 312382 ABCG2_32656 5.21654 5.21654 2.73368 2.73368 11.386 11.386 5.21654 2.73368 11.386 2 25351;24384 SLC2A2_9863;GC_32893 36.05575 36.05575 8.909898996341076 24.85605 24.85605 2.144159892592007 59.783150000000006 59.783150000000006 26.834914478063826 29.7555;42.356 23.3399;26.3722 40.808;78.7583 0 Exp 3,1(0.34);Exp 4,1(0.34);Linear,1(0.34) 1.597492746265263 4.805134415626526 1.5074360370635986 1.7682682275772095 0.1446609826947537 1.5294301509857178 4.403560396624979 47.148466270041695 2.927170444214422 32.03668288911891 5.429632671659391 81.87190066167395 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:1903010 6 regulation of bone development 6 6 2 2 2 2 2 2 160 4 2381 0.99562 0.050905 0.050905 33.33 25106;29441 rgn;por RGN_9699;POR_9531 44.941050000000004 44.941050000000004 12.4414 45.961445802378755 42.22129423009162 45.8002222412632 33.631505000000004 33.631505000000004 8.48981 35.55572605004783 31.527504801797043 35.431003673025884 84.5201 84.5201 79.2355 7.473552991716818 84.07785458069064 7.447337262283657 0.0 12.4414 0.0 12.4414 77.4407;12.4414 58.7732;8.48981 89.8047;79.2355 1 1 1 25106 RGN_9699 77.4407 77.4407 58.7732 58.7732 89.8047 89.8047 77.4407 58.7732 89.8047 1 29441 POR_9531 12.4414 12.4414 8.48981 8.48981 79.2355 79.2355 12.4414 8.48981 79.2355 0 Poly 2,2(1) 1.8462641963045523 3.701814651489258 1.7198865413665771 1.9819281101226807 0.18529137022020173 1.850907325744629 -18.75826399999999 108.640364 -15.646217199999995 82.9092272 74.162284 94.877916 CONFLICT 0.5 0.5 0.0 GO:1902532 7 negative regulation of intracellular signal transduction 138 146 12 12 9 11 8 8 154 138 2247 0.40842 0.72415 0.86075 5.48 293615;192235;24471;25675;81869;24890;116663;140942 sirt3;hyou1;hspb1;hmgcr;gstm7;esr1;dusp6;ddit4 SIRT3_9828;HYOU1_8857;HSPB1_8847;HMGCR_8810;GSTM7_8761;ESR1_33192;DUSP6_8506;DDIT4_8450 43.619783749999996 41.256699999999995 1.63089 34.30181761770981 49.61565929220889 34.05424370206388 29.122653375 30.39395 0.56209 22.047806313572586 33.338613262531695 22.494697907275743 82.53294625 63.478100000000005 7.6286 79.30435291222382 83.01591838195031 64.63049866661328 6.5 88.3216 2.38018;40.1982;89.1011;1.63089;42.3152;23.3972;62.3934;87.5421 0.56209;29.3844;60.3265;0.663137;31.4035;18.3088;39.0875;53.2453 8.82917;62.3571;106.138;7.6286;64.5991;31.9156;133.304;245.492 2 6 2 293615;81869 SIRT3_9828;GSTM7_8761 22.34769 22.34769 28.238323448820395 15.982795000000001 15.982795000000001 21.8081701523546 36.714135000000006 36.714135000000006 39.435295689299075 2.38018;42.3152 0.56209;31.4035 8.82917;64.5991 6 192235;24471;25675;24890;116663;140942 HYOU1_8857;HSPB1_8847;HMGCR_8810;ESR1_33192;DUSP6_8506;DDIT4_8450 50.71048166666666 51.2958 35.30503648280253 33.50260616666667 34.23595 22.211386189601672 97.80588333333333 84.24755 85.87294989465349 40.1982;89.1011;1.63089;23.3972;62.3934;87.5421 29.3844;60.3265;0.663137;18.3088;39.0875;53.2453 62.3571;106.138;7.6286;31.9156;133.304;245.492 0 Exp 2,3(0.38);Exp 4,1(0.13);Hill,1(0.13);Linear,2(0.25);Poly 2,1(0.13) 1.765378912001687 14.262215495109558 1.5209722518920898 2.436986207962036 0.2856372511756697 1.6822670698165894 19.84983686238335 67.38973063761665 13.84430308747754 44.40100366252245 27.577833442592322 137.4880590574077 DOWN 0.25 0.75 0.0 GO:0007271 8 synaptic transmission, cholinergic 4 4 1 1 1 1 1 1 161 3 2382 0.97784 0.23128 0.23128 25.0 170945 chrna2 CHRNA2_32401 49.3913 49.3913 49.3913 49.391299999999994 41.8524 41.8524 41.8524 41.8524 62.472 62.472 62.472 62.472 0.0 49.3913 0.0 49.3913 49.3913 41.8524 62.472 1 0 1 170945 CHRNA2_32401 49.3913 49.3913 41.8524 41.8524 62.472 62.472 49.3913 41.8524 62.472 0 0 Exp 2,1(1) 2.5185911655426025 2.5185911655426025 2.5185911655426025 2.5185911655426025 0.0 2.5185911655426025 49.3913 49.3913 41.8524 41.8524 62.472 62.472 UP 1.0 0.0 0.0 GO:0010594 6 regulation of endothelial cell migration 53 55 5 5 5 4 4 4 158 51 2334 0.73023 0.46756 0.77666 7.27 85253;24471;24957;25112 plg;hspb1;glul;gadd45a PLG_9501;HSPB1_8847;GLUL_32832;GADD45A_8678 72.318175 79.9434 26.4669 33.28044952114029 78.70752665092652 29.455272088335686 54.277225 53.28105 21.0456 28.55597296309769 59.593313286112895 27.4025007540178 101.89607500000001 110.7875 35.4303 48.26688654577275 110.6867548794448 42.12557342579653 1.5 79.9434 70.7857;89.1011;26.4669;102.919 46.2356;60.3265;21.0456;89.5012 150.579;106.138;35.4303;115.437 0 4 0 4 85253;24471;24957;25112 PLG_9501;HSPB1_8847;GLUL_32832;GADD45A_8678 72.318175 79.9434 33.28044952114029 54.277225 53.28105 28.55597296309769 101.89607500000001 110.7875 48.26688654577275 70.7857;89.1011;26.4669;102.919 46.2356;60.3265;21.0456;89.5012 150.579;106.138;35.4303;115.437 0 Linear,2(0.5);Poly 2,2(0.5) 1.778010895927549 7.219016194343567 1.5254690647125244 2.3622660636901855 0.37838770365833546 1.6656405329704285 39.70333446928251 104.93301553071748 26.292371496164257 82.26207850383574 54.5945261851427 149.1976238148573 DOWN 0.0 1.0 0.0 GO:0050778 6 positive regulation of immune response 121 142 6 6 4 5 3 3 159 139 2246 0.015792 0.99577 0.031828 2.11 63868;29184;313421 hspd1;cd36;c8b HSPD1_8849;CD36_8243;C8B_8181 37.249766666666666 42.2579 21.3618 14.069109027345435 40.9487281602739 12.276482802652154 26.233 23.9469 17.2088 10.35821714727009 29.096723827101055 10.277163541964452 66.48039999999999 69.1421 27.9161 37.304735410802756 71.9284733429626 32.122757638600575 42.2579;48.1296;21.3618 23.9469;37.5433;17.2088 102.383;69.1421;27.9161 2 1 2 63868;29184 HSPD1_8849;CD36_8243 45.19375 45.19375 4.151918887092963 30.7451 30.7451 9.61410663972478 85.76255 85.76255 23.504865802743858 42.2579;48.1296 23.9469;37.5433 102.383;69.1421 1 313421 C8B_8181 21.3618 21.3618 17.2088 17.2088 27.9161 27.9161 21.3618 17.2088 27.9161 0 Exp 2,2(0.67);Exp 3,1(0.34) 2.087251433235017 6.434409022331238 1.5122476816177368 2.6703107357025146 0.5864059177888037 2.2518506050109863 21.329071053642323 53.17046227969101 14.511573861730078 37.95442613826992 24.26611789830954 108.69468210169046 UP 0.6666666666666666 0.3333333333333333 0.0 GO:1903530 5 regulation of secretion by cell 205 222 25 24 17 20 14 14 148 208 2177 0.55709 0.55739 1.0 6.31 293615;81819;25591;100359982;24539;63868;25675;113965;24957;25661;361969;65210;113936;29184 sirt3;pax8;parp1;mpc2;lpl;hspd1;hmgcr;hadh;glul;fn1;fga;cyp2j4;cpb2;cd36 SIRT3_9828;PAX8_9432;PARP1_9425;MPC2_33219;LPL_32544;HSPD1_8849;HMGCR_8810;HADH_8776;GLUL_32832;FN1_8655;FGA_8632;CYP2J4_32580;CPB2_8369;CD36_8243 35.066047857142856 30.9464 1.63089 20.981771264402976 40.31194922747834 20.11195706182537 25.05670192857143 23.237949999999998 0.56209 14.373473997843865 28.434435954143364 13.327683983867347 58.093747857142866 42.918350000000004 7.6286 41.83806129300929 67.21309394516366 42.780961926478135 10.5 52.51135 2.38018;56.8931;26.9741;46.8463;74.2041;42.2579;1.63089;33.3125;26.4669;59.5777;28.5803;17.8395;25.8316;48.1296 0.56209;45.1162;21.799;35.8494;49.8682;23.9469;0.663137;25.7336;21.0456;31.0499;22.529;14.6501;20.4374;37.5433 8.82917;81.5688;35.2797;69.127;155.425;102.383;7.6286;46.9856;35.4303;105.243;38.8511;22.6149;34.8042;69.1421 9 5 9 293615;81819;25591;100359982;24539;63868;113965;65210;29184 SIRT3_9828;PAX8_9432;PARP1_9425;MPC2_33219;LPL_32544;HSPD1_8849;HADH_8776;CYP2J4_32580;CD36_8243 38.759697777777774 42.2579 21.44833272774471 28.340976666666663 25.7336 15.46730045892463 65.70614111111111 69.127 44.774252556267896 2.38018;56.8931;26.9741;46.8463;74.2041;42.2579;33.3125;17.8395;48.1296 0.56209;45.1162;21.799;35.8494;49.8682;23.9469;25.7336;14.6501;37.5433 8.82917;81.5688;35.2797;69.127;155.425;102.383;46.9856;22.6149;69.1421 5 25675;24957;25661;361969;113936 HMGCR_8810;GLUL_32832;FN1_8655;FGA_8632;CPB2_8369 28.417478 26.4669 20.609456338897445 19.145007399999997 21.0456 11.180786399897103 44.39144 35.4303 36.25372852387737 1.63089;26.4669;59.5777;28.5803;25.8316 0.663137;21.0456;31.0499;22.529;20.4374 7.6286;35.4303;105.243;38.8511;34.8042 0 Exp 2,6(0.43);Exp 3,1(0.08);Exp 4,1(0.08);Hill,1(0.08);Linear,4(0.29);Power,1(0.08) 1.9619366522631083 28.406167030334473 1.5209722518920898 3.8079800605773926 0.6132542606563587 1.8552199006080627 24.075123935675215 46.056971778610496 17.527415806502436 32.585988050640424 36.17763110520238 80.00986460908334 UP 0.6428571428571429 0.35714285714285715 0.0 GO:0032204 5 regulation of telomere maintenance 18 18 3 3 3 2 2 2 160 16 2369 0.89794 0.31912 0.31912 11.11 25591;290556 parp1;gnl3 PARP1_9425;GNL3_8735 57.3049 57.3049 26.9741 42.89422871762586 35.024657864034104 29.104921886262794 38.1045 38.1045 21.799 23.059459241274496 26.126890172761946 15.646481590213845 137.12135 137.12135 35.2797 144.0258426444539 62.31103765986089 97.7255221760757 0.0 26.9741 0.5 57.3049 26.9741;87.6357 21.799;54.41 35.2797;238.963 2 0 2 25591;290556 PARP1_9425;GNL3_8735 57.3049 57.3049 42.89422871762586 38.1045 38.1045 23.059459241274496 137.12135 137.12135 144.0258426444539 26.9741;87.6357 21.799;54.41 35.2797;238.963 0 0 Exp 2,2(1) 1.6918245808899273 3.391197681427002 1.582527995109558 1.8086696863174438 0.15990632336209026 1.695598840713501 -2.1434679999999915 116.75326799999999 6.145720000000004 70.06327999999999 -62.488283999999965 336.730984 UP 1.0 0.0 0.0 GO:0042542 5 response to hydrogen peroxide 74 80 8 8 8 7 7 7 155 73 2312 0.86754 0.24387 0.34955 8.75 24314;58954;24516;63868;24471;24464;24360 nqo1;klf6;jun;hspd1;hspb1;hp;fabp1 NQO1_33055;KLF6_8969;JUN_8938;HSPD1_8849;HSPB1_8847;HP_8823;FABP1_33091 50.39882857142857 42.2579 16.4324 30.419426711873594 51.87770517131058 27.81568921672205 33.61042857142857 26.4736 10.5224 21.092054510463914 34.200111750334486 18.973376792340538 96.35654285714286 102.383 39.929 57.881379795862294 92.82059298760981 44.1307070647909 3.0 42.2579 87.2765;18.9476;16.4324;42.2579;89.1011;64.9285;33.8478 60.6992;11.6941;10.5224;23.9469;60.3265;41.6103;26.4736 197.117;45.5481;39.929;102.383;106.138;136.455;46.9257 3 4 3 24314;63868;24360 NQO1_33055;HSPD1_8849;FABP1_33091 54.46073333333334 42.2579 28.72870258023033 37.039899999999996 26.4736 20.5284658606044 115.47523333333334 102.383 75.94676806265906 87.2765;42.2579;33.8478 60.6992;23.9469;26.4736 197.117;102.383;46.9257 4 58954;24516;24471;24464 KLF6_8969;JUN_8938;HSPB1_8847;HP_8823 47.3524 41.938050000000004 35.65927792286322 31.038325 26.6522 24.253288915715466 82.017525 75.84305 47.06980240418657 18.9476;16.4324;89.1011;64.9285 11.6941;10.5224;60.3265;41.6103 45.5481;39.929;106.138;136.455 0 Exp 2,3(0.43);Exp 3,1(0.15);Poly 2,3(0.43) 1.7839311338299175 12.587413311004639 1.5740432739257812 2.2518506050109863 0.2519318235869006 1.6973176002502441 27.86380190209221 72.93385524076494 17.98521592667897 49.23564121617816 53.477416642426405 139.23566907185932 CONFLICT 0.42857142857142855 0.5714285714285714 0.0 GO:0045637 6 regulation of myeloid cell differentiation 70 75 9 9 8 6 6 6 156 69 2316 0.80342 0.3416 0.47446 8.0 79426;25513;25493;24516;294515;314322 zfp36;pik3r1;nfkbia;jun;foxo3;fos ZFP36_10204;PIK3R1_32562;NFKBIA_9307;JUN_8938;FOXO3_8662;FOS_8657 8.205380833333548 6.8596755 1.28141E-12 8.849492265486553 9.877680924278977 9.00493983477161 4.691867333333547 2.920301 1.28141E-12 5.424702355919509 5.885971773453237 5.650929426070627 19.721585000000214 17.821545 1.28142E-12 20.365743383540412 23.404190336462896 20.70579040762297 2.5 6.8596755 0.348134;18.7324;0.520151;16.4324;13.1992;1.28141E-12 0.118102;11.6701;0.160202;10.5224;5.6804;1.28141E-12 1.15962;41.5978;2.88499;39.929;32.7581;1.28142E-12 0 6 0 6 79426;25513;25493;24516;294515;314322 ZFP36_10204;PIK3R1_32562;NFKBIA_9307;JUN_8938;FOXO3_8662;FOS_8657 8.205380833333548 6.8596755 8.849492265486553 4.691867333333547 2.920301 5.424702355919509 19.721585000000214 17.821545 20.365743383540412 0.348134;18.7324;0.520151;16.4324;13.1992;1.28141E-12 0.118102;11.6701;0.160202;10.5224;5.6804;1.28141E-12 1.15962;41.5978;2.88499;39.929;32.7581;1.28142E-12 0 Exp 4,2(0.34);Hill,2(0.34);Poly 2,2(0.34) 1.885175812207577 11.329878091812134 1.6735800504684448 1.9883413314819336 0.1165701400034098 1.917422354221344 1.124312259171739 15.286449407495354 0.35120142569786506 9.03253324096923 3.4255963561022575 36.017573643898174 DOWN 0.0 1.0 0.0 GO:0044093 4 positive regulation of molecular function 417 443 34 34 27 30 23 23 139 420 1965 0.15808 0.89017 0.33443 5.19 246273;24825;362895;29573;293615;25106;83516;29441;303612;25591;24516;63868;81869;29455;299626;25112;25661;24360;24890;29496;24330;114851;29184 trib3;tf;stac3;slc37a4;sirt3;rgn;ppargc1a;por;polg2;parp1;jun;hspd1;gstm7;gdf15;gadd45b;gadd45a;fn1;fabp1;esr1;erbb3;egr1;cdkn1a;cd36 TRIB3_10079;TF_10003;STAC3_9953;SLC37A4_9871;SIRT3_9828;RGN_9699;PPARGC1A_33189;POR_9531;POLG2_9521;PARP1_9425;JUN_8938;HSPD1_8849;GSTM7_8761;GDF15_33113;GADD45B_8679;GADD45A_8678;FN1_8655;FABP1_33091;ESR1_33192;ERBB3_8571;EGR1_8533;CDKN1A_8271;CD36_8243 49.12983769565217 42.4094 0.750017 33.47773776626906 48.30537918922114 32.42648377367978 34.14475517391305 28.132 0.186019 25.772325803030775 34.20642561397668 26.56014349534926 76.6242152173913 79.2355 4.70178 41.23190065122347 75.89374417159978 40.143871030745515 21.5 107.21549999999999 108.064;45.1539;63.2393;39.7166;2.38018;77.4407;42.4094;12.4414;63.7758;26.9741;16.4324;42.2579;42.3152;105.149;106.367;102.919;59.5777;33.8478;23.3972;60.9984;0.750017;6.24967;48.1296 83.8836;28.132;42.7031;22.6911;0.56209;58.7732;26.2988;8.48981;40.9553;21.799;10.5224;23.9469;31.4035;85.3487;52.7132;89.5012;31.0499;26.4736;18.3088;41.6036;0.186019;2.44025;37.5433 143.428;61.5341;121.52;60.0334;8.82917;89.8047;81.7305;79.2355;132.567;35.2797;39.929;102.383;64.5991;125.652;109.434;115.437;105.243;46.9257;31.9156;113.972;4.70178;19.0606;69.1421 10 13 10 24825;293615;25106;25591;63868;81869;299626;24360;29496;29184 TF_10003;SIRT3_9828;RGN_9699;PARP1_9425;HSPD1_8849;GSTM7_8761;GADD45B_8679;FABP1_33091;ERBB3_8571;CD36_8243 48.586478 43.73455 28.354751318307528 32.295038999999996 29.76775 16.56985569307139 70.190357 66.8706 34.17352741639906 45.1539;2.38018;77.4407;26.9741;42.2579;42.3152;106.367;33.8478;60.9984;48.1296 28.132;0.56209;58.7732;21.799;23.9469;31.4035;52.7132;26.4736;41.6036;37.5433 61.5341;8.82917;89.8047;35.2797;102.383;64.5991;109.434;46.9257;113.972;69.1421 13 246273;362895;29573;83516;29441;303612;24516;29455;25112;25661;24890;24330;114851 TRIB3_10079;STAC3_9953;SLC37A4_9871;PPARGC1A_33189;POR_9531;POLG2_9521;JUN_8938;GDF15_33113;GADD45A_8678;FN1_8655;ESR1_33192;EGR1_8533;CDKN1A_8271 49.547806692307695 42.4094 38.095872039359904 35.56761376923077 26.2988 31.72946408904203 81.57333692307692 81.7305 46.68930758659906 108.064;63.2393;39.7166;42.4094;12.4414;63.7758;16.4324;105.149;102.919;59.5777;23.3972;0.750017;6.24967 83.8836;42.7031;22.6911;26.2988;8.48981;40.9553;10.5224;85.3487;89.5012;31.0499;18.3088;0.186019;2.44025 143.428;121.52;60.0334;81.7305;79.2355;132.567;39.929;125.652;115.437;105.243;31.9156;4.70178;19.0606 0 Exp 2,6(0.27);Exp 3,1(0.05);Exp 4,1(0.05);Hill,2(0.09);Linear,3(0.14);Poly 2,8(0.35);Power,2(0.09) 1.9206625131968313 45.65524733066559 1.5209722518920898 4.21828556060791 0.6065313069639581 1.8086696863174438 35.44787958204378 62.81179580926057 23.611908403047345 44.67760194477875 59.77322183208251 93.47520860270008 CONFLICT 0.43478260869565216 0.5652173913043478 0.0 GO:0006084 8 acetyl-CoA metabolic process 16 16 8 8 6 6 5 5 157 11 2374 0.99972 0.0024076 0.0024076 31.25 298490;100359982;170570;170465;296925 ppcs;mpc2;acot12;acaa2;aass PPCS_9540;MPC2_33219;ACOT12_32718;ACAA2_7955;AASS_7936 30.315099999999994 27.4644 20.3353 9.936063735453814 29.792559542626535 8.80792274382341 23.94974 21.7498 16.7643 7.154267630093242 23.5812646611737 6.33926781107413 41.59416 37.0295 25.6711 16.39837497034385 40.65302927526484 14.560373250202662 0.0 20.3353 0.5 23.46125 20.3353;46.8463;30.3423;26.5872;27.4644 16.7643;35.8494;24.0157;21.3695;21.7498 25.6711;69.127;41.1025;35.0407;37.0295 5 0 5 298490;100359982;170570;170465;296925 PPCS_9540;MPC2_33219;ACOT12_32718;ACAA2_7955;AASS_7936 30.315099999999994 27.4644 9.936063735453814 23.94974 21.7498 7.154267630093242 41.59416 37.0295 16.39837497034385 20.3353;46.8463;30.3423;26.5872;27.4644 16.7643;35.8494;24.0157;21.3695;21.7498 25.6711;69.127;41.1025;35.0407;37.0295 0 0 Exp 2,4(0.8);Linear,1(0.2) 2.1176578197274383 10.76537799835205 1.7093055248260498 2.8333094120025635 0.45025156031169966 1.9288111925125122 21.605756135031896 39.024443864968106 17.67874792995499 30.220732070045006 27.220350587545774 55.96796941245423 UP 1.0 0.0 0.0 GO:0044242 5 cellular lipid catabolic process 56 64 28 28 17 27 16 16 146 48 2337 1.0 1.1609E-6 1.1609E-6 25.0 65192;24539;171155;113965;85255;295143;171142;291075;29740;83842;497840;50681;192272;24158;25287;170465 slc27a2;lpl;hadhb;hadh;hacl1;etfdh;ehhadh;eci2;eci1;crot;cps1;acox1;acot2;acadm;acadl;acaa2 SLC27A2_9860;LPL_32544;HADHB_8777;HADH_8776;HACL1_8775;ETFDH_8575;EHHADH_8534;ECI2_8521;ECI1_8520;CROT_8384;CPS1_32421;ACOX1_7973;ACOT2_7969;ACADM_7957;ACADL_32776;ACAA2_7955 22.302995624999998 17.875300000000003 7.4229 17.030990662030195 25.129270095486667 20.66735865592328 16.636856875 13.032 5.49916 11.88677471749155 18.48553706420477 13.937663738585401 35.01027500000001 28.2321 10.316 34.97590280299661 41.77462804775625 44.38892565886937 2.5 8.58857 5.5 11.8305 7.62189;74.2041;31.8029;33.3125;17.6275;18.1231;8.62809;10.6467;11.9473;7.4229;31.9826;23.1906;8.54905;11.7137;33.4878;26.5872 5.49916;49.8682;25.5756;25.7336;11.195;14.869;7.31865;8.92359;7.15307;5.75707;24.4836;16.2815;7.19676;8.36151;26.6039;21.3695 13.3925;155.425;42.1484;46.9856;37.6534;23.0103;10.3909;13.0581;19.001;10.316;45.5891;33.4539;10.4125;18.9642;45.3228;35.0407 15 1 15 65192;24539;171155;113965;85255;295143;171142;291075;29740;83842;50681;192272;24158;25287;170465 SLC27A2_9860;LPL_32544;HADHB_8777;HADH_8776;HACL1_8775;ETFDH_8575;EHHADH_8534;ECI2_8521;ECI1_8520;CROT_8384;ACOX1_7973;ACOT2_7969;ACADM_7957;ACADL_32776;ACAA2_7955 21.657688666666665 17.6275 17.425102145711623 16.113740666666665 11.195 12.111845033404558 34.30502 23.0103 36.08554750833082 7.62189;74.2041;31.8029;33.3125;17.6275;18.1231;8.62809;10.6467;11.9473;7.4229;23.1906;8.54905;11.7137;33.4878;26.5872 5.49916;49.8682;25.5756;25.7336;11.195;14.869;7.31865;8.92359;7.15307;5.75707;16.2815;7.19676;8.36151;26.6039;21.3695 13.3925;155.425;42.1484;46.9856;37.6534;23.0103;10.3909;13.0581;19.001;10.316;33.4539;10.4125;18.9642;45.3228;35.0407 1 497840 CPS1_32421 31.9826 31.9826 24.4836 24.4836 45.5891 45.5891 31.9826 24.4836 45.5891 0 Exp 2,6(0.38);Hill,2(0.13);Linear,4(0.25);Poly 2,3(0.19);Power,1(0.07) 3.4141942057145758 91.37722790241241 1.559399127960205 32.73371124267578 8.027056306636048 2.2722251415252686 13.957810200605207 30.648181049394793 10.812337263429143 22.461376486570856 17.872082626531665 52.14846737346835 UP 0.9375 0.0625 0.0 GO:0071333 8 cellular response to glucose stimulus 51 54 6 6 5 6 5 5 157 49 2336 0.87508 0.25736 0.38882 9.26 83516;294515;25661;25428;113936 ppargc1a;foxo3;fn1;cyp7a1;cpb2 PPARGC1A_33189;FOXO3_8662;FN1_8655;CYP7A1_8430;CPB2_8369 29.347836 25.8316 5.72128 21.884958534767208 45.465699228088155 19.637433766450823 16.890354600000002 20.4374 0.985273 13.040588605253053 25.105502947155305 10.341909813656391 55.37966 34.8042 22.3625 36.076089138694066 83.08041604305484 32.1585321158462 1.5 19.5154 42.4094;13.1992;59.5777;5.72128;25.8316 26.2988;5.6804;31.0499;0.985273;20.4374 81.7305;32.7581;105.243;22.3625;34.8042 0 5 0 5 83516;294515;25661;25428;113936 PPARGC1A_33189;FOXO3_8662;FN1_8655;CYP7A1_8430;CPB2_8369 29.347836 25.8316 21.884958534767208 16.890354600000002 20.4374 13.040588605253053 55.37966 34.8042 36.076089138694066 42.4094;13.1992;59.5777;5.72128;25.8316 26.2988;5.6804;31.0499;0.985273;20.4374 81.7305;32.7581;105.243;22.3625;34.8042 0 Exp 2,2(0.4);Exp 4,1(0.2);Hill,1(0.2);Power,1(0.2) 2.1346452662767903 11.64861249923706 1.5630855560302734 4.560328960418701 1.2560069958475946 1.7792335748672485 10.164824052346564 48.53084794765344 5.459774705521637 28.320934494478358 23.757573630826986 87.001746369173 DOWN 0.0 1.0 0.0 GO:0010639 7 negative regulation of organelle organization 85 89 3 3 3 3 3 3 159 86 2299 0.17016 0.93102 0.37186 3.37 83516;25591;170465 ppargc1a;parp1;acaa2 PPARGC1A_33189;PARP1_9425;ACAA2_7955 31.990233333333332 26.9741 26.5872 9.025336471474809 30.800337495335825 8.374709838241683 23.155766666666665 21.799 21.3695 2.7304049998733566 22.793483232276117 2.5380949817702403 50.68363333333334 35.2797 35.0407 26.887640796717985 47.14776180037314 24.94069558270674 42.4094;26.9741;26.5872 26.2988;21.799;21.3695 81.7305;35.2797;35.0407 2 1 2 25591;170465 PARP1_9425;ACAA2_7955 26.78065 26.78065 0.27357961364065125 21.584249999999997 21.584249999999997 0.3037023625198126 35.1602 35.1602 0.16899852070332533 26.9741;26.5872 21.799;21.3695 35.2797;35.0407 1 83516 PPARGC1A_33189 42.4094 42.4094 26.2988 26.2988 81.7305 81.7305 42.4094 26.2988 81.7305 0 Exp 2,3(1) 2.080621123493982 6.399602174758911 1.7576230764389038 2.8333094120025635 0.6068488851367837 1.8086696863174438 21.777103668320795 42.20336299834587 20.06602254578646 26.24551078754687 20.25740349568951 81.10986317097715 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0000185 10 activation of MAPKKK activity 4 5 2 2 2 2 2 2 160 3 2382 0.9977 0.035397 0.035397 40.0 299626;25112 gadd45b;gadd45a GADD45B_8679;GADD45A_8678 104.643 104.643 102.919 2.438104181530932 103.54518704505666 1.8798844198285591 71.1072 71.1072 52.7132 26.013044266290667 82.82017650419239 20.05718910576638 112.43549999999999 112.43549999999999 109.434 4.244762007463027 114.34680254307565 3.272896221646007 0.0 102.919 0.0 102.919 106.367;102.919 52.7132;89.5012 109.434;115.437 1 1 1 299626 GADD45B_8679 106.367 106.367 52.7132 52.7132 109.434 109.434 106.367 52.7132 109.434 1 25112 GADD45A_8678 102.919 102.919 89.5012 89.5012 115.437 115.437 102.919 89.5012 115.437 0 Poly 2,1(0.5);Power,1(0.5) 1.592820624899431 3.1866772174835205 1.5527137517929077 1.6339634656906128 0.05745222366653414 1.5933386087417603 101.26396 108.02204 35.054960000000015 107.15943999999999 106.55255999999999 118.31844 CONFLICT 0.5 0.5 0.0 GO:0007166 5 cell surface receptor signaling pathway 368 386 23 23 19 20 17 17 145 369 2016 0.050596 0.97048 0.090131 4.4 25513;25591;25493;58954;24516;25685;24471;24464;29455;289388;294515;314322;29496;116636;24330;140942;29184 pik3r1;parp1;nfkbia;klf6;jun;igfbp1;hspb1;hp;gdf15;g0s2;foxo3;fos;erbb3;eif4ebp1;egr1;ddit4;cd36 PIK3R1_32562;PARP1_9425;NFKBIA_9307;KLF6_8969;JUN_8938;IGFBP1_32306;HSPB1_8847;HP_8823;GDF15_33113;G0S2_32729;FOXO3_8662;FOS_8657;ERBB3_8571;EIF4EBP1_8550;EGR1_8533;DDIT4_8450;CD36_8243 42.98288047058831 46.3784 1.28141E-12 34.44220555141259 50.512298082542564 34.02849157528201 28.840477705882428 32.6883 1.28141E-12 24.22715683561481 34.696990156996144 24.53753016393027 74.68739823529418 69.1421 1.28142E-12 62.00830023324109 79.49656627025394 52.17797026686252 18.7324;26.9741;0.520151;18.9476;16.4324;49.0259;89.1011;64.9285;105.149;46.3784;13.1992;1.28141E-12;60.9984;83.9001;0.750017;87.5421;48.1296 11.6701;21.799;0.160202;11.6941;10.5224;32.6883;60.3265;41.6103;85.3487;33.7914;5.6804;1.28141E-12;41.6036;42.4185;0.186019;53.2453;37.5433 41.5978;35.2797;2.88499;45.5481;39.929;89.1623;106.138;136.455;125.652;73.6529;32.7581;1.28142E-12;113.972;107.32;4.70178;245.492;69.1421 5 12 5 25591;289388;29496;116636;29184 PARP1_9425;G0S2_32729;ERBB3_8571;EIF4EBP1_8550;CD36_8243 53.276120000000006 48.1296 20.99597118989733 35.43116 37.5433 8.36522071334643 79.87334 73.6529 31.85311551925493 26.9741;46.3784;60.9984;83.9001;48.1296 21.799;33.7914;41.6036;42.4185;37.5433 35.2797;73.6529;113.972;107.32;69.1421 12 25513;25493;58954;24516;25685;24471;24464;29455;294515;314322;24330;140942 PIK3R1_32562;NFKBIA_9307;KLF6_8969;JUN_8938;IGFBP1_32306;HSPB1_8847;HP_8823;GDF15_33113;FOXO3_8662;FOS_8657;EGR1_8533;DDIT4_8450 38.69403066666678 18.84 38.69042688193237 26.09436008333344 11.6821 28.290208671737837 72.52658916666677 43.57295 72.15607186824764 18.7324;0.520151;18.9476;16.4324;49.0259;89.1011;64.9285;105.149;13.1992;1.28141E-12;0.750017;87.5421 11.6701;0.160202;11.6941;10.5224;32.6883;60.3265;41.6103;85.3487;5.6804;1.28141E-12;0.186019;53.2453 41.5978;2.88499;45.5481;39.929;89.1623;106.138;136.455;125.652;32.7581;1.28142E-12;4.70178;245.492 0 Exp 2,4(0.24);Exp 3,1(0.06);Exp 4,2(0.12);Hill,2(0.12);Linear,3(0.18);Poly 2,5(0.3) 1.9988152657813023 35.737378001213074 1.5606178045272827 4.21828556060791 0.8005191195205688 1.8086696863174438 26.610095242546553 59.35566569863006 17.323618398963383 40.35733701280147 45.21052340045513 104.16427307013323 DOWN 0.29411764705882354 0.7058823529411765 0.0 GO:0046330 9 positive regulation of JNK cascade 32 35 3 3 3 3 3 3 159 32 2353 0.82057 0.38653 0.48519 8.57 24825;299626;25112 tf;gadd45b;gadd45a TF_10003;GADD45B_8679;GADD45A_8678 84.81330000000001 102.919 45.1539 34.38928877237791 80.66043509076647 34.9349262340619 56.78213333333334 52.7132 28.132 30.88627269537928 61.38675008964589 35.392279051330135 95.46836666666667 109.434 61.5341 29.54081655782946 93.64841312752128 31.653705615997087 0.5 74.03645 45.1539;106.367;102.919 28.132;52.7132;89.5012 61.5341;109.434;115.437 2 1 2 24825;299626 TF_10003;GADD45B_8679 75.76045 75.76045 43.28419810745022 40.4226 40.4226 17.38153320970276 85.48405 85.48405 33.8703441081575 45.1539;106.367 28.132;52.7132 61.5341;109.434 1 25112 GADD45A_8678 102.919 102.919 89.5012 89.5012 115.437 115.437 102.919 89.5012 115.437 0 Poly 2,2(0.67);Power,1(0.34) 1.6696094022726455 5.021148443222046 1.5527137517929077 1.8344712257385254 0.14502422324799494 1.6339634656906128 45.89815634525452 123.72844365474548 21.83102553764813 91.73324112901854 62.03978581884801 128.89694751448533 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0030001 7 metal ion transport 103 108 9 8 7 7 5 5 157 103 2282 0.30424 0.82963 0.54997 4.63 24825;29500;81678;304929;25303 tf;slc10a2;itpr2;f5;abcc2 TF_10003;SLC10A2_9833;ITPR2_8931;F5_33079;ABCC2_32541 38.0781 45.1539 10.6089 17.698051397964697 40.20531984833498 13.455394349854881 24.383178 28.132 2.59129 12.786474848503786 26.69427057987141 8.736001821596188 68.39126 61.5341 37.5078 32.02563523535482 66.07758925568744 28.86330689272646 45.1539;56.585;31.8111;10.6089;46.2316 28.132;35.2796;24.7342;2.59129;31.1788 61.5341;116.8;44.3296;37.5078;81.7848 1 4 1 24825 TF_10003 45.1539 45.1539 28.132 28.132 61.5341 61.5341 45.1539 28.132 61.5341 4 29500;81678;304929;25303 SLC10A2_9833;ITPR2_8931;F5_33079;ABCC2_32541 36.30915 39.02135 19.91900609208869 23.4459725 27.9565 14.564896992667855 70.10555000000001 63.0572 36.71416368301656 56.585;31.8111;10.6089;46.2316 35.2796;24.7342;2.59129;31.1788 116.8;44.3296;37.5078;81.7848 0 Exp 2,2(0.4);Hill,1(0.2);Linear,1(0.2);Poly 2,1(0.2) 1.7296081649931165 8.662377953529358 1.5972119569778442 1.8589661121368408 0.11148874648376171 1.7042291164398193 22.565073969907377 53.591126030092624 13.175338634092448 35.591017365907554 40.319553015724594 96.46296698427541 DOWN 0.2 0.8 0.0 GO:0010243 5 response to organonitrogen compound 400 420 57 56 43 52 39 39 123 381 2004 0.99631 0.0065764 0.011371 9.29 24522;286954;246273;24825;25351;29482;83516;29441;24651;25513;25591;25493;58954;24516;81678;63868;24471;29540;24464;113965;81869;294515;314322;25661;361969;29496;24330;25146;83842;497840;81718;114851;29184;25698;65054;25373;312382;140668;25303 zfp354a;ugt2b1;trib3;tf;slc2a2;slc1a2;ppargc1a;por;pklr;pik3r1;parp1;nfkbia;klf6;jun;itpr2;hspd1;hspb1;hsd17b7;hp;hadh;gstm7;foxo3;fos;fn1;fga;erbb3;egr1;cyp17a1;crot;cps1;cdo1;cdkn1a;cd36;ass1;aqp9;ahsg;abcg2;abcc3;abcc2 ZFP354A_10203;UGT2B10_33303,UGT2B1_33224;TRIB3_10079;TF_10003;SLC2A2_9863;SLC1A2_33059;PPARGC1A_33189;POR_9531;PKLR_9489;PIK3R1_32562;PARP1_9425;NFKBIA_9307;KLF6_8969;JUN_8938;ITPR2_8931;HSPD1_8849;HSPB1_8847;HSD17B7_8834;HP_8823;HADH_8776;GSTM7_8761;FOXO3_8662;FOS_8657;FN1_8655;FGA_8632;ERBB3_8571;EGR1_8533;CYP17A1_32365;CROT_8384;CPS1_32421;CDO1_8275;CDKN1A_8271;CD36_8243;ASS1_33159;AQP9_32709;AHSG_8003;ABCG2_32656;ABCC3_7941;ABCC2_32541 30.628514076923103 27.7316 1.28141E-12 24.288125196528522 32.77206030338836 23.976747874412755 21.51863674358978 21.9372 1.28141E-12 17.472855219147693 22.811406399905902 16.813929982617324 51.24220538461541 41.5978 1.28142E-12 37.44862052290657 54.68604117395627 37.91268461804443 20.0 28.5803 0.834827;47.47345;108.064;45.1539;29.7555;13.3235;42.4094;12.4414;23.0963;18.7324;26.9741;0.520151;18.9476;16.4324;31.8111;42.2579;89.1011;0.977494;64.9285;33.3125;42.3152;13.1992;1.28141E-12;59.5777;28.5803;60.9984;0.750017;49.6922;7.4229;31.9826;22.9638;6.24967;48.1296;26.8037;27.7316;12.402;5.21654;37.7175;46.2316 0.27095;34.82915;83.8836;28.132;23.3399;9.10952;26.2988;8.48981;17.4625;11.6701;21.799;0.160202;11.6941;10.5224;24.7342;23.9469;60.3265;0.322682;41.6103;25.7336;31.4035;5.6804;1.28141E-12;31.0499;22.529;41.6036;0.186019;35.6654;5.75707;24.4836;18.5144;2.44025;37.5433;20.9825;21.9372;10.3013;2.73368;30.9007;31.1788 2.99857;76.47475;143.428;61.5341;40.808;24.6773;81.7305;79.2355;32.9443;41.5978;35.2797;2.88499;45.5481;39.929;44.3296;102.383;106.138;5.49472;136.455;46.9856;64.5991;32.7581;1.28142E-12;105.243;38.8511;113.972;4.70178;81.6409;10.316;45.5891;30.0179;19.0606;69.1421;36.7081;37.4625;15.4235;11.386;48.9329;81.7848 13 27 12 286954;24825;25591;63868;113965;81869;29496;25146;83842;29184;312382;140668 UGT2B10_33303,UGT2B1_33224;TF_10003;PARP1_9425;HSPD1_8849;HADH_8776;GSTM7_8761;ERBB3_8571;CYP17A1_32365;CROT_8384;CD36_8243;ABCG2_32656;ABCC3_7941 37.22201583333334 42.28655 16.765744453961887 26.670658333333336 29.516350000000003 11.960119759087869 60.22051249999999 63.06660000000001 32.03735103410994 47.47345;45.1539;26.9741;42.2579;33.3125;42.3152;60.9984;49.6922;7.4229;48.1296;5.21654;37.7175 34.82915;28.132;21.799;23.9469;25.7336;31.4035;41.6036;35.6654;5.75707;37.5433;2.73368;30.9007 76.47475;61.5341;35.2797;102.383;46.9856;64.5991;113.972;81.6409;10.316;69.1421;11.386;48.9329 27 24522;246273;25351;29482;83516;29441;24651;25513;25493;58954;24516;81678;24471;29540;24464;294515;314322;25661;361969;24330;497840;81718;114851;25698;65054;25373;25303 ZFP354A_10203;TRIB3_10079;SLC2A2_9863;SLC1A2_33059;PPARGC1A_33189;POR_9531;PKLR_9489;PIK3R1_32562;NFKBIA_9307;KLF6_8969;JUN_8938;ITPR2_8931;HSPB1_8847;HSD17B7_8834;HP_8823;FOXO3_8662;FOS_8657;FN1_8655;FGA_8632;EGR1_8533;CPS1_32421;CDO1_8275;CDKN1A_8271;ASS1_33159;AQP9_32709;AHSG_8003;ABCC2_32541 27.698068851851897 22.9638 26.72592301026066 19.22884937037042 17.4625 19.183177731520928 47.25184666666672 38.8511 39.51806712113648 0.834827;108.064;29.7555;13.3235;42.4094;12.4414;23.0963;18.7324;0.520151;18.9476;16.4324;31.8111;89.1011;0.977494;64.9285;13.1992;1.28141E-12;59.5777;28.5803;0.750017;31.9826;22.9638;6.24967;26.8037;27.7316;12.402;46.2316 0.27095;83.8836;23.3399;9.10952;26.2988;8.48981;17.4625;11.6701;0.160202;11.6941;10.5224;24.7342;60.3265;0.322682;41.6103;5.6804;1.28141E-12;31.0499;22.529;0.186019;24.4836;18.5144;2.44025;20.9825;21.9372;10.3013;31.1788 2.99857;143.428;40.808;24.6773;81.7305;79.2355;32.9443;41.5978;2.88499;45.5481;39.929;44.3296;106.138;5.49472;136.455;32.7581;1.28142E-12;105.243;38.8511;4.70178;45.5891;30.0179;19.0606;36.7081;37.4625;15.4235;81.7848 0 Exp 2,12(0.3);Exp 3,1(0.03);Exp 4,5(0.13);Hill,3(0.08);Linear,9(0.23);Poly 2,9(0.23);Power,1(0.03) 2.0183719176251844 85.58313167095184 1.5074360370635986 5.963563919067383 0.9198559507765054 1.8304733633995056 23.00565728859352 38.25137086525269 16.034760489616204 27.00251299756335 39.488911589529984 62.995499179700865 DOWN 0.3076923076923077 0.6923076923076923 0.0 GO:0010823 8 negative regulation of mitochondrion organization 22 22 2 2 2 2 2 2 160 20 2365 0.83934 0.41295 0.64706 9.09 83516;170465 ppargc1a;acaa2 PPARGC1A_33189;ACAA2_7955 34.4983 34.4983 26.5872 11.187984913289778 32.9580909475527 10.973901702198686 23.83415 23.83415 21.3695 3.4855414565028036 23.354308228171273 3.418845271874177 58.385600000000004 58.385600000000004 35.0407 33.014674192243675 53.84059029104968 32.38293509722513 0.5 34.4983 42.4094;26.5872 26.2988;21.3695 81.7305;35.0407 1 1 1 170465 ACAA2_7955 26.5872 26.5872 21.3695 21.3695 35.0407 35.0407 26.5872 21.3695 35.0407 1 83516 PPARGC1A_33189 42.4094 42.4094 26.2988 26.2988 81.7305 81.7305 42.4094 26.2988 81.7305 0 Exp 2,2(1) 2.231566715387924 4.590932488441467 1.7576230764389038 2.8333094120025635 0.7606251023067718 2.2954662442207336 18.992544000000002 50.004056 19.003436 28.664864 12.629596 104.141604 CONFLICT 0.5 0.5 0.0 GO:0006511 8 ubiquitin-dependent protein catabolic process 65 67 2 2 2 2 2 2 160 65 2320 0.18903 0.93452 0.44002 2.99 312688;29676 usp18;psmb3 USP18_10138;PSMB3_9589 66.3359 66.3359 23.7888 60.17068585964431 62.54822486869747 59.93178181081743 46.206900000000005 46.206900000000005 19.2724 38.09113519573812 43.80910706407563 37.93989666001823 84.52250000000001 84.52250000000001 30.901 75.83225253478892 79.74894734768907 75.53116518796216 108.883;23.7888 73.1414;19.2724 138.144;30.901 2 0 2 312688;29676 USP18_10138;PSMB3_9589 66.3359 66.3359 60.17068585964431 46.206900000000005 46.206900000000005 38.09113519573812 84.52250000000001 84.52250000000001 75.83225253478892 108.883;23.7888 73.1414;19.2724 138.144;30.901 0 0 Exp 2,1(0.5);Power,1(0.5) 1.666155438001131 3.3332111835479736 1.6278724670410156 1.705338716506958 0.054776910310456624 1.6666055917739868 -17.056416 149.72821599999997 -6.58471999999999 98.99852 -20.57563999999998 189.62063999999998 UP 1.0 0.0 0.0 GO:0071702 5 organic substance transport 316 335 41 39 29 38 27 27 135 308 2077 0.92803 0.10829 0.18545 8.06 79426;171139;170698;29573;25351;65192;361074;29482;29500;297784;308821;298199;25513;25493;100359982;63868;24471;85255;24360;25428;83842;114851;29184;65054;312382;140668;25303 zfp36;timm9;slco1a2;slc37a4;slc2a2;slc27a2;slc25a30;slc1a2;slc10a2;rrs1;rab30;plin2;pik3r1;nfkbia;mpc2;hspd1;hspb1;hacl1;fabp1;cyp7a1;crot;cdkn1a;cd36;aqp9;abcg2;abcc3;abcc2 ZFP36_10204;TIMM9_10020;SLCO1A2_9886;SLC37A4_9871;SLC2A2_9863;SLC27A2_9860;SLC25A30_9856;SLC1A2_33059;SLC10A2_9833;RRS1_9755;RAB30_9639;PLIN2_9502;PIK3R1_32562;NFKBIA_9307;MPC2_33219;HSPD1_8849;HSPB1_8847;HACL1_8775;FABP1_33091;CYP7A1_8430;CROT_8384;CDKN1A_8271;CD36_8243;AQP9_32709;ABCG2_32656;ABCC3_7941;ABCC2_32541 171139(0.04986) 32.92205796296297 29.7555 0.348134 25.8074889623111 33.35082617263705 24.032275770906452 23.389724333333337 22.6911 0.118102 19.05198017827881 23.262307806520138 17.24431860478799 52.27791148148148 41.5978 1.15962 36.810094195255395 53.777635538432584 35.2119856881711 15.5 38.118300000000005 0.348134;38.5191;104.197;39.7166;29.7555;7.62189;53.013;13.3235;56.585;60.39;26.4203;25.6517;18.7324;0.520151;46.8463;42.2579;89.1011;17.6275;33.8478;5.72128;7.4229;6.24967;48.1296;27.7316;5.21654;37.7175;46.2316 0.118102;29.55;80.3101;22.6911;23.3399;5.49916;37.4804;9.10952;35.2796;43.109;21.0125;20.9252;11.6701;0.160202;35.8494;23.9469;60.3265;11.195;26.4736;0.985273;5.75707;2.44025;37.5433;21.9372;2.73368;30.9007;31.1788 1.15962;55.4685;128.412;60.0334;40.808;13.3925;90.2594;24.6773;116.8;104.942;35.3561;33.0375;41.5978;2.88499;69.127;102.383;106.138;37.6534;46.9257;22.3625;10.316;19.0606;69.1421;37.4625;11.386;48.9329;81.7848 14 13 14 171139;65192;361074;297784;308821;298199;100359982;63868;85255;24360;83842;29184;312382;140668 TIMM9_10020;SLC27A2_9860;SLC25A30_9856;RRS1_9755;RAB30_9639;PLIN2_9502;MPC2_33219;HSPD1_8849;HACL1_8775;FABP1_33091;CROT_8384;CD36_8243;ABCG2_32656;ABCC3_7941 32.19157357142857 35.782650000000004 17.770136949123653 23.712565 25.210250000000002 13.196097475226269 52.023007142857146 47.9293 31.81613139538504 38.5191;7.62189;53.013;60.39;26.4203;25.6517;46.8463;42.2579;17.6275;33.8478;7.4229;48.1296;5.21654;37.7175 29.55;5.49916;37.4804;43.109;21.0125;20.9252;35.8494;23.9469;11.195;26.4736;5.75707;37.5433;2.73368;30.9007 55.4685;13.3925;90.2594;104.942;35.3561;33.0375;69.127;102.383;37.6534;46.9257;10.316;69.1421;11.386;48.9329 13 79426;170698;29573;25351;29482;29500;25513;25493;24471;25428;114851;65054;25303 ZFP36_10204;SLCO1A2_9886;SLC37A4_9871;SLC2A2_9863;SLC1A2_33059;SLC10A2_9833;PIK3R1_32562;NFKBIA_9307;HSPB1_8847;CYP7A1_8430;CDKN1A_8271;AQP9_32709;ABCC2_32541 33.708733461538465 27.7316 33.161300253318 23.04204976923077 21.9372 24.44486183381291 52.55242384615384 40.808 42.8837661320877 0.348134;104.197;39.7166;29.7555;13.3235;56.585;18.7324;0.520151;89.1011;5.72128;6.24967;27.7316;46.2316 0.118102;80.3101;22.6911;23.3399;9.10952;35.2796;11.6701;0.160202;60.3265;0.985273;2.44025;21.9372;31.1788 1.15962;128.412;60.0334;40.808;24.6773;116.8;41.5978;2.88499;106.138;22.3625;19.0606;37.4625;81.7848 0 Exp 2,9(0.34);Exp 3,1(0.04);Exp 4,3(0.12);Hill,3(0.12);Linear,4(0.15);Poly 2,7(0.26) 2.1205304204009305 61.260451436042786 1.5074360370635986 5.963563919067383 1.0233968849203234 1.8753424882888794 23.187416972623875 42.656698953302055 16.203275955443868 30.576172711222792 38.39306385703105 66.16275910593193 CONFLICT 0.5185185185185185 0.48148148148148145 0.0 GO:0006457 3 protein folding 33 38 3 3 2 3 2 2 160 36 2349 0.56102 0.70748 1.0 5.26 63868;24471 hspd1;hspb1 HSPD1_8849;HSPB1_8847 65.6795 65.6795 42.2579 33.12314437247769 67.11450179434091 33.06091699908637 42.136700000000005 42.136700000000005 23.9469 25.724261856854103 43.251158262403194 25.675934523259755 104.26050000000001 104.26050000000001 102.383 2.655185963354776 104.37553124760372 2.6501977518944098 0.5 65.6795 42.2579;89.1011 23.9469;60.3265 102.383;106.138 1 1 1 63868 HSPD1_8849 42.2579 42.2579 23.9469 23.9469 102.383 102.383 42.2579 23.9469 102.383 1 24471 HSPB1_8847 89.1011 89.1011 60.3265 60.3265 106.138 106.138 89.1011 60.3265 106.138 0 Exp 3,1(0.5);Poly 2,1(0.5) 1.955020630330869 3.9491682052612305 1.6973176002502441 2.2518506050109863 0.3921140480580728 1.9745841026306152 19.773164000000016 111.585836 6.484692000000003 77.78870800000001 100.5806 107.94040000000001 CONFLICT 0.5 0.5 0.0 GO:0008360 5 regulation of cell shape 41 41 2 2 2 2 2 2 160 39 2346 0.51033 0.74666 1.0 4.88 25661;155423 fn1;anxa7 FN1_8655;ANXA7_8051 82.10885 82.10885 59.5777 31.86385790586252 74.83154062999468 30.15604379409651 37.48765 37.48765 31.0499 9.10435336116738 35.4083287759723 8.616385356958896 106.966 106.966 105.243 2.436689967968911 106.40949027703782 2.3060901666029188 59.5777;104.64 31.0499;43.9254 105.243;108.689 1 1 1 155423 ANXA7_8051 104.64 104.64 43.9254 43.9254 108.689 108.689 104.64 43.9254 108.689 1 25661 FN1_8655 59.5777 59.5777 31.0499 31.0499 105.243 105.243 59.5777 31.0499 105.243 0 Exp 3,1(0.5);Power,1(0.5) 1.6586169189327762 3.3254106044769287 1.5461770296096802 1.7792335748672485 0.1647958635515361 1.6627053022384644 37.947796000000004 126.269904 24.869660000000003 50.10564 103.58892 110.34307999999999 CONFLICT 0.5 0.5 0.0 GO:0070374 9 positive regulation of ERK1 and ERK2 cascade 75 80 6 6 6 5 5 5 157 75 2310 0.59995 0.58397 1.0 6.25 24516;25675;361969;24890;29184 jun;hmgcr;fga;esr1;cd36 JUN_8938;HMGCR_8810;FGA_8632;ESR1_33192;CD36_8243 23.634078000000006 23.3972 1.63089 17.0334690351942 32.32000437362099 15.072679703677782 17.9133274 18.3088 0.663137 13.774900481245004 24.941413012257907 12.2661018010807 37.493280000000006 38.8511 7.6286 21.979728388608436 48.10100455585519 19.25142253080648 3.0 28.5803 16.4324;1.63089;28.5803;23.3972;48.1296 10.5224;0.663137;22.529;18.3088;37.5433 39.929;7.6286;38.8511;31.9156;69.1421 1 4 1 29184 CD36_8243 48.1296 48.1296 37.5433 37.5433 69.1421 69.1421 48.1296 37.5433 69.1421 4 24516;25675;361969;24890 JUN_8938;HMGCR_8810;FGA_8632;ESR1_33192 17.510197500000004 19.9148 11.697834869839154 13.00583425 14.415600000000001 9.614602656495602 29.581075000000002 35.38335 15.05959363005855 16.4324;1.63089;28.5803;23.3972 10.5224;0.663137;22.529;18.3088 39.929;7.6286;38.8511;31.9156 0 Exp 2,2(0.4);Exp 4,1(0.2);Linear,1(0.2);Poly 2,1(0.2) 2.0672502583711427 10.529468774795532 1.541895866394043 2.6703107357025146 0.448379442463481 1.9785058498382568 8.703584095109855 38.56457190489015 5.83909476713151 29.98756003286849 18.227198612867124 56.75936138713287 DOWN 0.2 0.8 0.0 GO:0051649 4 establishment of localization in cell 242 254 15 14 13 14 13 13 149 241 2144 0.24071 0.83922 0.49724 5.12 257644;171139;29482;297784;308821;25513;25493;81678;192235;63868;24471;85255;114851 zwint;timm9;slc1a2;rrs1;rab30;pik3r1;nfkbia;itpr2;hyou1;hspd1;hspb1;hacl1;cdkn1a ZWINT_10214;TIMM9_10020;SLC1A2_33059;RRS1_9755;RAB30_9639;PIK3R1_32562;NFKBIA_9307;ITPR2_8931;HYOU1_8857;HSPD1_8849;HSPB1_8847;HACL1_8775;CDKN1A_8271 171139(0.04986) 33.627016999999995 31.8111 0.520151 24.261936456367803 34.37453917444356 26.087435738256538 23.50308246153846 23.9469 0.160202 17.18466871279772 23.614055582947085 18.2478288722364 55.20843769230768 44.3296 2.88499 34.13744298242478 56.15865199502105 35.054444997689174 11.5 74.74555000000001 52.0003;38.5191;13.3235;60.39;26.4203;18.7324;0.520151;31.8111;40.1982;42.2579;89.1011;17.6275;6.24967 38.9015;29.55;9.10952;43.109;21.0125;11.6701;0.160202;24.7342;29.3844;23.9469;60.3265;11.195;2.44025 80.8613;55.4685;24.6773;104.942;35.3561;41.5978;2.88499;44.3296;62.3571;102.383;106.138;37.6534;19.0606 6 7 6 257644;171139;297784;308821;63868;85255 ZWINT_10214;TIMM9_10020;RRS1_9755;RAB30_9639;HSPD1_8849;HACL1_8775 39.53585 40.3885 15.815782461294786 27.952483333333333 26.74845 11.80825420719196 69.44405 68.1649 31.12356740251667 52.0003;38.5191;60.39;26.4203;42.2579;17.6275 38.9015;29.55;43.109;21.0125;23.9469;11.195 80.8613;55.4685;104.942;35.3561;102.383;37.6534 7 29482;25513;25493;81678;192235;24471;114851 SLC1A2_33059;PIK3R1_32562;NFKBIA_9307;ITPR2_8931;HYOU1_8857;HSPB1_8847;CDKN1A_8271 28.562303000000004 18.7324 30.066478324969143 19.68931028571429 11.6701 20.920415515088617 43.006484285714286 41.5978 33.86952491064884 13.3235;18.7324;0.520151;31.8111;40.1982;89.1011;6.24967 9.10952;11.6701;0.160202;24.7342;29.3844;60.3265;2.44025 24.6773;41.5978;2.88499;44.3296;62.3571;106.138;19.0606 0 Exp 2,4(0.31);Exp 3,1(0.08);Exp 4,2(0.16);Linear,2(0.16);Poly 2,4(0.31) 1.8134483007553837 24.02600336074829 1.5207922458648682 2.945132255554199 0.40956303258703686 1.6735800504684448 20.43807810511177 46.81595589488823 14.161390136625096 32.84477478645182 36.65111229774867 73.76576308686671 CONFLICT 0.46153846153846156 0.5384615384615384 0.0 GO:0032269 7 negative regulation of cellular protein metabolic process 274 292 33 33 31 32 30 30 132 262 2123 0.99786 0.0042348 0.006888 10.27 79426;246273;293615;79224;24794;24648;25106;252922;83516;29441;25513;299282;288001;24516;54404;50693;306251;24471;25675;299626;25112;83928;24360;116636;116663;140942;113936;114851;25377;25373 zfp36;trib3;sirt3;serpind1;serpina3c;serpina1;rgn;pzp;ppargc1a;por;pik3r1;loc299282;kng1;jun;itih4;itih3;itih1;hspb1;hmgcr;gadd45b;gadd45a;fetub;fabp1;eif4ebp1;dusp6;ddit4;cpb2;cdkn1a;ambp;ahsg ZFP36_10204;TRIB3_10079;SIRT3_9828;SERPIND1_9812;SERPINA3C_32925;SERPINA1_9807;RGN_9699;PZP_9633;PPARGC1A_33189;POR_9531;PIK3R1_32562;LOC299282_9119;KNG1L1_34113;JUN_8938;ITIH4_32725;ITIH3_32422;ITIH1_33132;HSPB1_8847;HMGCR_8810;GADD45B_8679;GADD45A_8678;FETUB_33027;FABP1_33091;EIF4EBP1_8550;DUSP6_8506;DDIT4_8450;CPB2_8369;CDKN1A_8271;AMBP_33085;AHSG_8003 43.339215800000005 31.14075 0.348134 34.78315465479699 49.03330578966558 35.084165567648874 29.032582966666666 22.826999999999998 0.118102 23.28758207056697 32.751894873109805 24.995815511092232 66.65419299999999 47.74615 1.15962 52.71201828277214 72.87372747645756 44.690052550655636 13.5 29.0135 28.5 107.21549999999999 0.348134;108.064;2.38018;28.261;29.766;15.797;77.4407;34.1871;42.4094;12.4414;18.7324;45.2017;24.3655;16.4324;57.1163;27.1247;98.1741;89.1011;1.63089;106.367;102.919;32.5155;33.8478;83.9001;62.3934;87.5421;25.8316;6.24967;17.2343;12.402 0.118102;83.8836;0.56209;22.307;23.347;13.013;58.7732;26.3085;26.2988;8.48981;11.6701;30.7472;19.538;10.5224;39.6402;21.5108;42.9071;60.3265;0.663137;52.7132;89.5012;19.6094;26.4736;42.4185;39.0875;53.2453;20.4374;2.44025;14.1233;10.3013 1.15962;143.428;8.82917;38.3264;40.8256;19.9134;89.8047;48.5666;81.7305;79.2355;41.5978;78.6415;32.1467;39.929;101.869;36.4819;104.278;106.138;7.6286;109.434;115.437;49.9875;46.9257;107.32;133.304;245.492;34.8042;19.0606;21.9073;15.4235 5 25 5 293615;25106;299626;24360;116636 SIRT3_9828;RGN_9699;GADD45B_8679;FABP1_33091;EIF4EBP1_8550 60.787156 77.4407 41.91114002962313 36.188118 42.4185 23.37502756655315 72.462714 89.8047 43.54313338587359 2.38018;77.4407;106.367;33.8478;83.9001 0.56209;58.7732;52.7132;26.4736;42.4185 8.82917;89.8047;109.434;46.9257;107.32 25 79426;246273;79224;24794;24648;252922;83516;29441;25513;299282;288001;24516;54404;50693;306251;24471;25675;25112;83928;116663;140942;113936;114851;25377;25373 ZFP36_10204;TRIB3_10079;SERPIND1_9812;SERPINA3C_32925;SERPINA1_9807;PZP_9633;PPARGC1A_33189;POR_9531;PIK3R1_32562;LOC299282_9119;KNG1L1_34113;JUN_8938;ITIH4_32725;ITIH3_32422;ITIH1_33132;HSPB1_8847;HMGCR_8810;GADD45A_8678;FETUB_33027;DUSP6_8506;DDIT4_8450;CPB2_8369;CDKN1A_8271;AMBP_33085;AHSG_8003 39.84962776 28.261 33.06143854425859 27.60147596 21.5108 23.48248916522721 65.4924888 41.5978 55.07256497657252 0.348134;108.064;28.261;29.766;15.797;34.1871;42.4094;12.4414;18.7324;45.2017;24.3655;16.4324;57.1163;27.1247;98.1741;89.1011;1.63089;102.919;32.5155;62.3934;87.5421;25.8316;6.24967;17.2343;12.402 0.118102;83.8836;22.307;23.347;13.013;26.3085;26.2988;8.48981;11.6701;30.7472;19.538;10.5224;39.6402;21.5108;42.9071;60.3265;0.663137;89.5012;19.6094;39.0875;53.2453;20.4374;2.44025;14.1233;10.3013 1.15962;143.428;38.3264;40.8256;19.9134;48.5666;81.7305;79.2355;41.5978;78.6415;32.1467;39.929;101.869;36.4819;104.278;106.138;7.6286;115.437;49.9875;133.304;245.492;34.8042;19.0606;21.9073;15.4235 0 Exp 2,8(0.27);Exp 3,2(0.07);Exp 4,2(0.07);Hill,2(0.07);Linear,7(0.24);Poly 2,8(0.27);Power,1(0.04) 1.79769654379102 54.97735142707825 1.5197933912277222 3.431420087814331 0.4171884768902091 1.6763167977333069 30.89222376192621 55.786207838073786 20.6992287469291 37.365937186404224 47.791439509468624 85.51694649053135 DOWN 0.16666666666666666 0.8333333333333334 0.0 GO:0018298 7 protein-chromophore linkage 4 4 1 1 1 1 1 1 161 3 2382 0.97784 0.23128 0.23128 25.0 25377 ambp AMBP_33085 17.2343 17.2343 17.2343 17.2343 14.1233 14.1233 14.1233 14.1233 21.9073 21.9073 21.9073 21.9073 0.0 17.2343 0.0 17.2343 17.2343 14.1233 21.9073 0 1 0 1 25377 AMBP_33085 17.2343 17.2343 14.1233 14.1233 21.9073 21.9073 17.2343 14.1233 21.9073 0 Exp 2,1(1) 1.6425341367721558 1.6425341367721558 1.6425341367721558 1.6425341367721558 0.0 1.6425341367721558 17.2343 17.2343 14.1233 14.1233 21.9073 21.9073 DOWN 0.0 1.0 0.0 GO:0006629 4 lipid metabolic process 289 320 88 88 63 73 52 52 110 268 2117 1.0 1.076E-11 1.076E-11 16.25 24856;293688;25357;361510;360268;29573;65192;29500;246074;501907;83516;29441;25513;24539;29540;289456;25675;171155;113965;85255;81869;29328;24384;246186;295143;24890;65030;25315;171142;291075;29740;298541;25428;266682;65210;24894;25146;83842;497840;362866;29184;25284;65183;362732;50681;192272;170570;50559;24158;25287;170465;313917 ttr;tm7sf2;thrsp;sult2a2;sult1e1;slc37a4;slc27a2;slc10a2;scd;rgd1559459;ppargc1a;por;pik3r1;lpl;hsd17b7;hsd17b11;hmgcr;hadhb;hadh;hacl1;gstm7;gpx4;gc;fgl1;etfdh;esr1;ephx2;ephx1;ehhadh;eci2;eci1;dhdds;cyp7a1;cyp3a2;cyp2j4;cyp2a1;cyp17a1;crot;cps1;chpt1;cd36;amacr;aldh3a2;agmo;acox1;acot2;acot12;acot1;acadm;acadl;acaa2;abhd1 TTR_10102;TM7SF2_10031;THRSP_33314;SULT2A2_33196;SULT1E1_32446;SLC37A4_9871;SLC27A2_9860;SLC10A2_9833;SCD1_9787;RGD1559459_9690;PPARGC1A_33189;POR_9531;PIK3R1_32562;LPL_32544;HSD17B7_8834;HSD17B11_8832;HMGCR_8810;HADHB_8777;HADH_8776;HACL1_8775;GSTM7_8761;GPX4_32827;GC_32893;FGL1_8640;ETFDH_8575;ESR1_33192;EPHX2_33282;EPHX1_8567;EHHADH_8534;ECI2_8521;ECI1_8520;DHDDS_8467;CYP7A1_8430;CYP3A2_32374;CYP2J4_32580;CYP2A1_32717;CYP17A1_32365;CROT_8384;CPS1_32421;CHPT1_33298;CD36_8243;AMACR_8038;ALDH3A2_8024;AGMO_33265;ACOX1_7973;ACOT2_7969;ACOT12_32718;ACOT1_7968;ACADM_7957;ACADL_32776;ACAA2_7955;ABHD1_7949 29.857217961538467 28.464750000000002 2.52378E-13 21.792918431815725 30.913923274553504 20.437583840793813 20.98458696153847 22.030299999999997 2.52378E-13 14.380144186013249 21.815497483794953 13.484855164420106 55.72961211538464 41.35015 2.52379E-13 64.91021701530187 56.0009762346074 58.899483563242526 15.0 15.4757 31.0 32.2053 46.6406;82.3097;32.2053;54.1932;50.1846;39.7166;7.62189;56.585;105.46;2.52378E-13;42.4094;12.4414;18.7324;74.2041;0.977494;22.4334;1.63089;31.8029;33.3125;17.6275;42.3152;45.9204;42.356;15.4757;18.1231;23.3972;38.7293;12.4747;8.62809;10.6467;11.9473;47.9438;5.72128;12.8505;17.8395;55.3937;49.6922;7.4229;31.9826;16.0559;48.1296;2.03774;43.1079;31.5332;23.1906;8.54905;30.3423;31.2018;11.7137;33.4878;26.5872;17.2895 28.5876;51.1696;24.3966;35.5514;36.5009;22.6911;5.49916;35.2796;63.7532;2.52378E-13;26.2988;8.48981;11.6701;49.8682;0.322682;18.1233;0.663137;25.5756;25.7336;11.195;31.4035;34.2198;26.3722;10.2138;14.869;18.3088;29.2097;7.00435;7.31865;8.92359;7.15307;36.5688;0.985273;7.33176;14.6501;38.7444;35.6654;5.75707;24.4836;10.6021;37.5433;1.165;31.8774;24.5474;16.2815;7.19676;24.0157;26.858;8.36151;26.6039;21.3695;14.2242 63.7146;209.842;46.6068;103.141;80.9788;60.0334;13.3925;116.8;422.699;2.52379E-13;81.7305;79.2355;41.5978;155.425;5.49472;29.2247;7.6286;42.1484;46.9856;37.6534;64.5991;70.4292;78.7583;30.4106;23.0103;31.9156;57.2113;23.684;10.3909;13.0581;19.001;71.3742;22.3625;24.0283;22.6149;96.8569;81.6409;10.316;45.5891;29.905;69.1421;3.73641;66.3058;43.8459;33.4539;10.4125;41.1025;37.2719;18.9642;45.3228;35.0407;21.8526 36 16 36 24856;360268;65192;246074;24539;289456;171155;113965;85255;81869;29328;295143;65030;25315;171142;291075;29740;298541;266682;65210;24894;25146;83842;362866;29184;25284;65183;362732;50681;192272;170570;50559;24158;25287;170465;313917 TTR_10102;SULT1E1_32446;SLC27A2_9860;SCD1_9787;LPL_32544;HSD17B11_8832;HADHB_8777;HADH_8776;HACL1_8775;GSTM7_8761;GPX4_32827;ETFDH_8575;EPHX2_33282;EPHX1_8567;EHHADH_8534;ECI2_8521;ECI1_8520;DHDDS_8467;CYP3A2_32374;CYP2J4_32580;CYP2A1_32717;CYP17A1_32365;CROT_8384;CHPT1_33298;CD36_8243;AMACR_8038;ALDH3A2_8024;AGMO_33265;ACOX1_7973;ACOT2_7969;ACOT12_32718;ACOT1_7968;ACADM_7957;ACADL_32776;ACAA2_7955;ABHD1_7949 30.345588055555552 28.464750000000002 21.349890860919555 22.063945000000004 22.6926 14.188815205370028 53.79981694444445 37.46265 70.22215299145212 46.6406;50.1846;7.62189;105.46;74.2041;22.4334;31.8029;33.3125;17.6275;42.3152;45.9204;18.1231;38.7293;12.4747;8.62809;10.6467;11.9473;47.9438;12.8505;17.8395;55.3937;49.6922;7.4229;16.0559;48.1296;2.03774;43.1079;31.5332;23.1906;8.54905;30.3423;31.2018;11.7137;33.4878;26.5872;17.2895 28.5876;36.5009;5.49916;63.7532;49.8682;18.1233;25.5756;25.7336;11.195;31.4035;34.2198;14.869;29.2097;7.00435;7.31865;8.92359;7.15307;36.5688;7.33176;14.6501;38.7444;35.6654;5.75707;10.6021;37.5433;1.165;31.8774;24.5474;16.2815;7.19676;24.0157;26.858;8.36151;26.6039;21.3695;14.2242 63.7146;80.9788;13.3925;422.699;155.425;29.2247;42.1484;46.9856;37.6534;64.5991;70.4292;23.0103;57.2113;23.684;10.3909;13.0581;19.001;71.3742;24.0283;22.6149;96.8569;81.6409;10.316;29.905;69.1421;3.73641;66.3058;43.8459;33.4539;10.4125;41.1025;37.2719;18.9642;45.3228;35.0407;21.8526 16 293688;25357;361510;29573;29500;501907;83516;29441;25513;29540;25675;24384;246186;24890;25428;497840 TM7SF2_10031;THRSP_33314;SULT2A2_33196;SLC37A4_9871;SLC10A2_9833;RGD1559459_9690;PPARGC1A_33189;POR_9531;PIK3R1_32562;HSD17B7_8834;HMGCR_8810;GC_32893;FGL1_8640;ESR1_33192;CYP7A1_8430;CPS1_32421 28.758385250000014 27.6899 23.437813414369298 18.556031375000014 20.49995 14.974695507232111 60.071651250000016 46.09795 52.82307080889457 82.3097;32.2053;54.1932;39.7166;56.585;2.52378E-13;42.4094;12.4414;18.7324;0.977494;1.63089;42.356;15.4757;23.3972;5.72128;31.9826 51.1696;24.3966;35.5514;22.6911;35.2796;2.52378E-13;26.2988;8.48981;11.6701;0.322682;0.663137;26.3722;10.2138;18.3088;0.985273;24.4836 209.842;46.6068;103.141;60.0334;116.8;2.52379E-13;81.7305;79.2355;41.5978;5.49472;7.6286;78.7583;30.4106;31.9156;22.3625;45.5891 0 Exp 2,18(0.35);Exp 3,1(0.02);Exp 4,3(0.06);Hill,6(0.12);Linear,14(0.27);Poly 2,9(0.18);Power,1(0.02) 2.6669807236960117 512.1747770309448 1.511321783065796 344.14306640625 47.50020653363875 1.9055876731872559 23.93383525761865 35.78060066545827 17.076019248691424 24.893154674385485 38.08681415883363 73.37241007193559 UP 0.6923076923076923 0.3076923076923077 0.0 GO:0006520 6 cellular amino acid metabolic process 85 90 10 10 7 10 7 7 155 83 2302 0.7898 0.34696 0.51057 7.78 364070;24443;24957;497840;81718;25698;296925 iars2;hdc;glul;cps1;cdo1;ass1;aass IARS2_8858;HDC_8788;GLUL_32832;CPS1_32421;CDO1_8275;ASS1_33159;AASS_7936 26.426614285714287 26.4669 22.9638 2.8979402463523005 26.7541396508017 3.1973213633560915 21.091414285714283 21.0456 18.5144 1.8375056457315617 21.144963460929088 2.1040831887746974 35.25194285714285 35.4303 29.28 5.502970749773044 36.202297693136444 5.647288270049071 3.5 26.6353 24.7304;24.5745;26.4669;31.9826;22.9638;26.8037;27.4644 19.8021;21.0619;21.0456;24.4836;18.5144;20.9825;21.7498 32.7087;29.28;35.4303;45.5891;30.0179;36.7081;37.0295 3 4 3 364070;24443;296925 IARS2_8858;HDC_8788;AASS_7936 25.589766666666666 24.7304 1.6253503632550532 20.871266666666667 21.0619 0.9877447156696018 33.00606666666667 32.7087 3.883298567369401 24.7304;24.5745;27.4644 19.8021;21.0619;21.7498 32.7087;29.28;37.0295 4 24957;497840;81718;25698 GLUL_32832;CPS1_32421;CDO1_8275;ASS1_33159 27.05425 26.6353 3.716098772009889 21.256525 21.01405 2.4530825252798523 36.936350000000004 36.0692 6.456400380759109 26.4669;31.9826;22.9638;26.8037 21.0456;24.4836;18.5144;20.9825 35.4303;45.5891;30.0179;36.7081 0 Exp 2,3(0.43);Linear,4(0.58) 2.670215363107044 29.278002977371216 1.7569831609725952 17.513065338134766 5.881460543886237 1.9288111925125122 24.279790107985704 28.57343846344287 19.73017105375511 22.45265751767346 31.175285075873507 39.328600638412226 CONFLICT 0.42857142857142855 0.5714285714285714 0.0 GO:0008209 6 androgen metabolic process 15 15 7 7 6 4 4 4 158 11 2374 0.99826 0.012381 0.012381 26.67 83516;289456;24890;25146 ppargc1a;hsd17b11;esr1;cyp17a1 PPARGC1A_33189;HSD17B11_8832;ESR1_33192;CYP17A1_32365 34.483050000000006 32.9033 22.4334 13.689842991429792 33.07774135935549 13.105960110805245 24.599075 22.303800000000003 18.1233 8.303730798211541 23.465471717916714 7.382793841235989 56.127925000000005 56.77825 29.2247 29.53203874488123 54.188049937592204 29.97280534790174 0.0 22.4334 0.5 22.915300000000002 42.4094;22.4334;23.3972;49.6922 26.2988;18.1233;18.3088;35.6654 81.7305;29.2247;31.9156;81.6409 2 2 2 289456;25146 HSD17B11_8832;CYP17A1_32365 36.062799999999996 36.062799999999996 19.274882327007877 26.89435 26.89435 12.404137866252542 55.4328 55.4328 37.06385046403031 22.4334;49.6922 18.1233;35.6654 29.2247;81.6409 2 83516;24890 PPARGC1A_33189;ESR1_33192 32.9033 32.9033 13.443655545274869 22.303800000000003 22.303800000000003 5.6497831816805 56.82305 56.82305 35.224453594129756 42.4094;23.3972 26.2988;18.3088 81.7305;31.9156 0 Exp 2,2(0.5);Linear,2(0.5) 1.9841975997852432 7.999248147010803 1.7576230764389038 2.436986207962036 0.29938090666827755 1.9023194313049316 21.067003868398785 47.89909613160121 16.4614188177527 32.7367311822473 27.18652703001639 85.06932296998362 CONFLICT 0.5 0.5 0.0 GO:0010817 4 regulation of hormone levels 159 176 28 27 22 21 17 17 145 159 2226 0.9727 0.050651 0.076172 9.66 24856;360268;293615;83516;29441;81819;100359982;29540;289456;25675;113965;24957;361969;24890;24330;25146;25303 ttr;sult1e1;sirt3;ppargc1a;por;pax8;mpc2;hsd17b7;hsd17b11;hmgcr;hadh;glul;fga;esr1;egr1;cyp17a1;abcc2 TTR_10102;SULT1E1_32446;SIRT3_9828;PPARGC1A_33189;POR_9531;PAX8_9432;MPC2_33219;HSD17B7_8834;HSD17B11_8832;HMGCR_8810;HADH_8776;GLUL_32832;FGA_8632;ESR1_33192;EGR1_8533;CYP17A1_32365;ABCC2_32541 28.898122411764707 28.5803 0.750017 19.647071758922635 30.695734258427994 18.769263445113094 20.891831647058822 22.529 0.186019 14.438111045105218 22.364508172592938 13.941670941113474 48.75543941176471 46.9856 4.70178 30.60246691997771 51.01865240757406 28.73476233807808 7.5 27.523600000000002 46.6406;50.1846;2.38018;42.4094;12.4414;56.8931;46.8463;0.977494;22.4334;1.63089;33.3125;26.4669;28.5803;23.3972;0.750017;49.6922;46.2316 28.5876;36.5009;0.56209;26.2988;8.48981;45.1162;35.8494;0.322682;18.1233;0.663137;25.7336;21.0456;22.529;18.3088;0.186019;35.6654;31.1788 63.7146;80.9788;8.82917;81.7305;79.2355;81.5688;69.127;5.49472;29.2247;7.6286;46.9856;35.4303;38.8511;31.9156;4.70178;81.6409;81.7848 8 9 8 24856;360268;293615;81819;100359982;289456;113965;25146 TTR_10102;SULT1E1_32446;SIRT3_9828;PAX8_9432;MPC2_33219;HSD17B11_8832;HADH_8776;CYP17A1_32365 38.54786 46.743449999999996 18.227531380797103 28.26731125 32.1265 13.840413645310543 57.75869625 66.4208 27.164872585725185 46.6406;50.1846;2.38018;56.8931;46.8463;22.4334;33.3125;49.6922 28.5876;36.5009;0.56209;45.1162;35.8494;18.1233;25.7336;35.6654 63.7146;80.9788;8.82917;81.5688;69.127;29.2247;46.9856;81.6409 9 83516;29441;29540;25675;24957;361969;24890;24330;25303 PPARGC1A_33189;POR_9531;HSD17B7_8834;HMGCR_8810;GLUL_32832;FGA_8632;ESR1_33192;EGR1_8533;ABCC2_32541 20.320577888888888 23.3972 17.476093109541193 14.335849777777778 18.3088 12.105968467450536 40.75254444444445 35.4303 32.77532907336519 42.4094;12.4414;0.977494;1.63089;26.4669;28.5803;23.3972;0.750017;46.2316 26.2988;8.48981;0.322682;0.663137;21.0456;22.529;18.3088;0.186019;31.1788 81.7305;79.2355;5.49472;7.6286;35.4303;38.8511;31.9156;4.70178;81.7848 0 Exp 2,6(0.36);Exp 4,2(0.12);Hill,2(0.12);Linear,5(0.3);Poly 2,2(0.12) 1.964913739591383 34.413947343826294 1.5209722518920898 4.21828556060791 0.6122501393541481 1.9017701148986816 19.558497346564096 38.237747476965325 14.028389325188417 27.755273968929234 34.20795006526732 63.30292875826208 CONFLICT 0.47058823529411764 0.5294117647058824 0.0 GO:0031581 8 hemidesmosome assembly 2 2 1 1 1 1 1 1 161 1 2384 0.99598 0.12319 0.12319 50.0 307582 lama3 LAMA3_8980 2.46923 2.46923 2.46923 2.46923 0.871501 0.871501 0.871501 0.8715010000000001 10.4175 10.4175 10.4175 10.4175 0.0 2.46923 0.0 2.46923 2.46923 0.871501 10.4175 0 1 0 1 307582 LAMA3_8980 2.46923 2.46923 0.871501 0.871501 10.4175 10.4175 2.46923 0.871501 10.4175 0 Exp 4,1(1) 1.6902168989181519 1.6902168989181519 1.6902168989181519 1.6902168989181519 0.0 1.6902168989181519 2.46923 2.46923 0.871501 0.871501 10.4175 10.4175 DOWN 0.0 1.0 0.0 GO:0045926 5 negative regulation of growth 66 72 5 5 4 4 4 4 158 68 2317 0.51207 0.68314 1.0 5.56 24567;29455;114851;25373 mt1;gdf15;cdkn1a;ahsg MT1A_9255;GDF15_33113;CDKN1A_8271;AHSG_8003 34.1830425 12.66675 6.24967 47.40774301782243 40.05295222385321 52.23441084601226 26.750144999999996 9.605815 2.44025 39.21557999939692 31.31187539036698 43.42678467177748 45.899924999999996 21.2621 15.4235 53.269578540187155 53.51297064678899 57.84042190835962 2.5 59.04025 12.9315;105.149;6.24967;12.402 8.91033;85.3487;2.44025;10.3013 23.4636;125.652;19.0606;15.4235 0 4 0 4 24567;29455;114851;25373 MT1A_9255;GDF15_33113;CDKN1A_8271;AHSG_8003 34.1830425 12.66675 47.40774301782243 26.750144999999996 9.605815 39.21557999939692 45.899924999999996 21.2621 53.269578540187155 12.9315;105.149;6.24967;12.402 8.91033;85.3487;2.44025;10.3013 23.4636;125.652;19.0606;15.4235 0 Exp 2,1(0.25);Exp 4,1(0.25);Poly 2,2(0.5) 2.074779294032912 8.78752601146698 1.522104263305664 3.431420087814331 0.8925793978849555 1.9170008301734924 -12.276545657465988 80.64263065746599 -11.681123399408989 65.18141339940898 -6.304261969383397 98.10411196938341 DOWN 0.0 1.0 0.0 GO:1904093 8 negative regulation of autophagic cell death 1 1 1 1 1 1 1 1 161 0 2385 1.0 0.063604 0.063604 100.0 246142 bmf BMF_8152 94.8767 94.8767 94.8767 94.8767 73.1342 73.1342 73.1342 73.1342 109.848 109.848 109.848 109.848 0.0 94.8767 0.0 94.8767 94.8767 73.1342 109.848 1 0 1 246142 BMF_8152 94.8767 94.8767 73.1342 73.1342 109.848 109.848 94.8767 73.1342 109.848 0 0 Poly 2,1(1) 1.701177716255188 1.701177716255188 1.701177716255188 1.701177716255188 0.0 1.701177716255188 94.8767 94.8767 73.1342 73.1342 109.848 109.848 UP 1.0 0.0 0.0 GO:0010821 7 regulation of mitochondrion organization 47 48 3 3 3 3 3 3 159 45 2340 0.63507 0.59835 1.0 6.25 83516;246142;170465 ppargc1a;bmf;acaa2 PPARGC1A_33189;BMF_8152;ACAA2_7955 54.624433333333336 42.4094 26.5872 35.74589811521501 58.4065727604726 38.017924275884816 40.267500000000005 26.2988 21.3695 28.569905080171342 43.81379027712138 30.082951986181445 75.53973333333333 81.7305 35.0407 37.785939544536035 76.85957552309344 40.028540412419716 1.5 68.64305 42.4094;94.8767;26.5872 26.2988;73.1342;21.3695 81.7305;109.848;35.0407 2 1 2 246142;170465 BMF_8152;ACAA2_7955 60.73195 60.73195 48.28796853383874 47.251850000000005 47.251850000000005 36.60317039608728 72.44435 72.44435 52.8967491122564 94.8767;26.5872 73.1342;21.3695 109.848;35.0407 1 83516 PPARGC1A_33189 42.4094 42.4094 26.2988 26.2988 81.7305 81.7305 42.4094 26.2988 81.7305 0 Exp 2,2(0.67);Poly 2,1(0.34) 2.0385583421136717 6.292110204696655 1.701177716255188 2.8333094120025635 0.6379667373409149 1.7576230764389038 14.17414169081443 95.07472497585223 7.937608918032396 72.5973910819676 32.78091749279655 118.29854917387014 UP 0.6666666666666666 0.3333333333333333 0.0 GO:0032879 4 regulation of localization 652 690 59 58 48 50 41 41 121 649 1736 0.33507 0.7294 0.64834 5.94 79426;246273;24825;362895;170698;29482;293615;25106;83516;298199;85253;25513;81819;25591;25493;100359982;24539;307582;24516;81678;63868;24471;25675;113965;81869;290556;24957;25112;294515;25661;361969;24890;29496;24330;65210;113936;29184;25373;170465;312382;25303 zfp36;trib3;tf;stac3;slco1a2;slc1a2;sirt3;rgn;ppargc1a;plin2;plg;pik3r1;pax8;parp1;nfkbia;mpc2;lpl;lama3;jun;itpr2;hspd1;hspb1;hmgcr;hadh;gstm7;gnl3;glul;gadd45a;foxo3;fn1;fga;esr1;erbb3;egr1;cyp2j4;cpb2;cd36;ahsg;acaa2;abcg2;abcc2 ZFP36_10204;TRIB3_10079;TF_10003;STAC3_9953;SLCO1A2_9886;SLC1A2_33059;SIRT3_9828;RGN_9699;PPARGC1A_33189;PLIN2_9502;PLG_9501;PIK3R1_32562;PAX8_9432;PARP1_9425;NFKBIA_9307;MPC2_33219;LPL_32544;LAMA3_8980;JUN_8938;ITPR2_8931;HSPD1_8849;HSPB1_8847;HMGCR_8810;HADH_8776;GSTM7_8761;GNL3_8735;GLUL_32832;GADD45A_8678;FOXO3_8662;FN1_8655;FGA_8632;ESR1_33192;ERBB3_8571;EGR1_8533;CYP2J4_32580;CPB2_8369;CD36_8243;AHSG_8003;ACAA2_7955;ABCG2_32656;ABCC2_32541 39.56723029268294 31.8111 0.348134 30.85202141329704 43.13843612170221 28.729474822400892 28.34743295121951 23.9469 0.118102 23.200794725804613 30.965563943793256 22.006378488973773 64.40179658536586 44.3296 1.15962 52.28516726168028 68.511809455096 46.358952579157126 33.5 72.4949 0.348134;108.064;45.1539;63.2393;104.197;13.3235;2.38018;77.4407;42.4094;25.6517;70.7857;18.7324;56.8931;26.9741;0.520151;46.8463;74.2041;2.46923;16.4324;31.8111;42.2579;89.1011;1.63089;33.3125;42.3152;87.6357;26.4669;102.919;13.1992;59.5777;28.5803;23.3972;60.9984;0.750017;17.8395;25.8316;48.1296;12.402;26.5872;5.21654;46.2316 0.118102;83.8836;28.132;42.7031;80.3101;9.10952;0.56209;58.7732;26.2988;20.9252;46.2356;11.6701;45.1162;21.799;0.160202;35.8494;49.8682;0.871501;10.5224;24.7342;23.9469;60.3265;0.663137;25.7336;31.4035;54.41;21.0456;89.5012;5.6804;31.0499;22.529;18.3088;41.6036;0.186019;14.6501;20.4374;37.5433;10.3013;21.3695;2.73368;31.1788 1.15962;143.428;61.5341;121.52;128.412;24.6773;8.82917;89.8047;81.7305;33.0375;150.579;41.5978;81.5688;35.2797;2.88499;69.127;155.425;10.4175;39.929;44.3296;102.383;106.138;7.6286;46.9856;64.5991;238.963;35.4303;115.437;32.7581;105.243;38.8511;31.9156;113.972;4.70178;22.6149;34.8042;69.1421;15.4235;35.0407;11.386;81.7848 17 24 17 24825;293615;25106;298199;81819;25591;100359982;24539;63868;113965;81869;290556;29496;65210;29184;170465;312382 TF_10003;SIRT3_9828;RGN_9699;PLIN2_9502;PAX8_9432;PARP1_9425;MPC2_33219;LPL_32544;HSPD1_8849;HADH_8776;GSTM7_8761;GNL3_8735;ERBB3_8571;CYP2J4_32580;CD36_8243;ACAA2_7955;ABCG2_32656 42.3433305882353 42.3152 24.161216555070357 30.259968823529416 28.132 16.586249968618535 72.9230805882353 64.5991 57.58560436890808 45.1539;2.38018;77.4407;25.6517;56.8931;26.9741;46.8463;74.2041;42.2579;33.3125;42.3152;87.6357;60.9984;17.8395;48.1296;26.5872;5.21654 28.132;0.56209;58.7732;20.9252;45.1162;21.799;35.8494;49.8682;23.9469;25.7336;31.4035;54.41;41.6036;14.6501;37.5433;21.3695;2.73368 61.5341;8.82917;89.8047;33.0375;81.5688;35.2797;69.127;155.425;102.383;46.9856;64.5991;238.963;113.972;22.6149;69.1421;35.0407;11.386 24 79426;246273;362895;170698;29482;83516;85253;25513;25493;307582;24516;81678;24471;25675;24957;25112;294515;25661;361969;24890;24330;113936;25373;25303 ZFP36_10204;TRIB3_10079;STAC3_9953;SLCO1A2_9886;SLC1A2_33059;PPARGC1A_33189;PLG_9501;PIK3R1_32562;NFKBIA_9307;LAMA3_8980;JUN_8938;ITPR2_8931;HSPB1_8847;HMGCR_8810;GLUL_32832;GADD45A_8678;FOXO3_8662;FN1_8655;FGA_8632;ESR1_33192;EGR1_8533;CPB2_8369;AHSG_8003;ABCC2_32541 37.600825916666665 26.149250000000002 35.20736242061405 26.99272004166667 20.741500000000002 27.20548826466158 58.36588708333334 39.39005 48.53646664572081 0.348134;108.064;63.2393;104.197;13.3235;42.4094;70.7857;18.7324;0.520151;2.46923;16.4324;31.8111;89.1011;1.63089;26.4669;102.919;13.1992;59.5777;28.5803;23.3972;0.750017;25.8316;12.402;46.2316 0.118102;83.8836;42.7031;80.3101;9.10952;26.2988;46.2356;11.6701;0.160202;0.871501;10.5224;24.7342;60.3265;0.663137;21.0456;89.5012;5.6804;31.0499;22.529;18.3088;0.186019;20.4374;10.3013;31.1788 1.15962;143.428;121.52;128.412;24.6773;81.7305;150.579;41.5978;2.88499;10.4175;39.929;44.3296;106.138;7.6286;35.4303;115.437;32.7581;105.243;38.8511;31.9156;4.70178;34.8042;15.4235;81.7848 0 Exp 2,13(0.32);Exp 3,1(0.03);Exp 4,5(0.13);Hill,3(0.08);Linear,9(0.22);Poly 2,9(0.22);Power,1(0.03) 1.9487025836510798 82.79323351383209 1.5074360370635986 4.21828556060791 0.6229595926491425 1.8086696863174438 30.123408850557354 49.01105173480849 21.24565638459641 35.44920951784262 48.39727691139193 80.40631625933979 CONFLICT 0.4146341463414634 0.5853658536585366 0.0 GO:0030502 7 negative regulation of bone mineralization 4 5 1 1 1 1 1 1 161 4 2381 0.9646 0.28025 0.28025 20.0 25373 ahsg AHSG_8003 12.402 12.402 12.402 12.402000000000001 10.3013 10.3013 10.3013 10.3013 15.4235 15.4235 15.4235 15.423499999999999 0.0 12.402 0.0 12.402 12.402 10.3013 15.4235 0 1 0 1 25373 AHSG_8003 12.402 12.402 10.3013 10.3013 15.4235 15.4235 12.402 10.3013 15.4235 0 Exp 2,1(1) 3.431420087814331 3.431420087814331 3.431420087814331 3.431420087814331 0.0 3.431420087814331 12.402 12.402 10.3013 10.3013 15.4235 15.4235 DOWN 0.0 1.0 0.0 GO:0045937 8 positive regulation of phosphate metabolic process 306 327 23 23 19 19 15 15 147 312 2073 0.095631 0.94195 0.18197 4.59 24825;25106;83516;25513;24516;25675;29455;299626;25112;361969;24890;29496;24330;114851;29184 tf;rgn;ppargc1a;pik3r1;jun;hmgcr;gdf15;gadd45b;gadd45a;fga;esr1;erbb3;egr1;cdkn1a;cd36 TF_10003;RGN_9699;PPARGC1A_33189;PIK3R1_32562;JUN_8938;HMGCR_8810;GDF15_33113;GADD45B_8679;GADD45A_8678;FGA_8632;ESR1_33192;ERBB3_8571;EGR1_8533;CDKN1A_8271;CD36_8243 45.62265846666666 42.4094 0.750017 37.455110155395765 48.43294421978035 36.488911366718014 32.4155804 26.2988 0.186019 28.642865749592694 36.28176258837878 30.394482554181412 63.359392 61.5341 4.70178 40.94553295652429 67.1178730616766 40.479623981516106 45.1539;77.4407;42.4094;18.7324;16.4324;1.63089;105.149;106.367;102.919;28.5803;23.3972;60.9984;0.750017;6.24967;48.1296 28.132;58.7732;26.2988;11.6701;10.5224;0.663137;85.3487;52.7132;89.5012;22.529;18.3088;41.6036;0.186019;2.44025;37.5433 61.5341;89.8047;81.7305;41.5978;39.929;7.6286;125.652;109.434;115.437;38.8511;31.9156;113.972;4.70178;19.0606;69.1421 5 10 5 24825;25106;299626;29496;29184 TF_10003;RGN_9699;GADD45B_8679;ERBB3_8571;CD36_8243 67.61792 60.9984 25.130773285893923 43.75306 41.6036 12.176694209759905 88.77738 89.8047 23.400110784930092 45.1539;77.4407;106.367;60.9984;48.1296 28.132;58.7732;52.7132;41.6036;37.5433 61.5341;89.8047;109.434;113.972;69.1421 10 83516;25513;24516;25675;29455;25112;361969;24890;24330;114851 PPARGC1A_33189;PIK3R1_32562;JUN_8938;HMGCR_8810;GDF15_33113;GADD45A_8678;FGA_8632;ESR1_33192;EGR1_8533;CDKN1A_8271 34.6250277 21.064799999999998 38.70936483929325 26.746840599999995 14.989450000000001 33.21423182541809 50.650398 39.39005 42.73392715859426 42.4094;18.7324;16.4324;1.63089;105.149;102.919;28.5803;23.3972;0.750017;6.24967 26.2988;11.6701;10.5224;0.663137;85.3487;89.5012;22.529;18.3088;0.186019;2.44025 81.7305;41.5978;39.929;7.6286;125.652;115.437;38.8511;31.9156;4.70178;19.0606 0 Exp 2,3(0.2);Exp 4,2(0.14);Hill,1(0.07);Linear,2(0.14);Poly 2,6(0.4);Power,1(0.07) 1.8921206276108882 29.60401713848114 1.522104263305664 4.21828556060791 0.7048905450996419 1.7198865413665771 26.66775746600431 64.57755946732905 17.92029037398523 46.910870426014775 42.638093347018476 84.0806906529815 DOWN 0.3333333333333333 0.6666666666666666 0.0 GO:0045862 8 positive regulation of proteolysis 112 119 8 8 7 6 5 5 157 114 2271 0.2185 0.88684 0.44018 4.2 246273;25106;63868;25661;25423 trib3;rgn;hspd1;fn1;ctsc TRIB3_10079;RGN_9699;HSPD1_8849;FN1_8655;CTSC_32456 68.71578 59.5777 42.2579 25.316055118777886 64.29882472717351 21.574026837399412 47.18434 38.2681 23.9469 24.294729203327222 42.220725084879355 21.142442866317715 108.74933999999999 102.888 89.8047 20.302024873839677 106.37358344549533 16.452079137057222 108.064;77.4407;42.2579;59.5777;56.2386 83.8836;58.7732;23.9469;31.0499;38.2681 143.428;89.8047;102.383;105.243;102.888 2 3 2 25106;63868 RGN_9699;HSPD1_8849 59.8493 59.8493 24.877996461130085 41.36005 41.36005 24.625912893637068 96.09385 96.09385 8.894201225798568 77.4407;42.2579 58.7732;23.9469 89.8047;102.383 3 246273;25661;25423 TRIB3_10079;FN1_8655;CTSC_32456 74.62676666666665 59.5777 29.00558268580952 51.06719999999999 38.2681 28.648083435545917 117.18633333333332 105.243 22.75643443805156 108.064;59.5777;56.2386 83.8836;31.0499;38.2681 143.428;105.243;102.888 0 Exp 2,1(0.2);Exp 3,1(0.2);Poly 2,2(0.4);Power,1(0.2) 1.826984102889069 9.201748132705688 1.5736411809921265 2.2518506050109863 0.2549834460799949 1.7792335748672485 46.525279294254204 90.90628070574579 25.88907093051313 68.47960906948687 90.95383058207165 126.54484941792836 DOWN 0.4 0.6 0.0 GO:0048545 5 response to steroid hormone 158 177 33 33 24 30 22 22 140 155 2230 0.99943 0.0013907 0.0019485 12.43 79426;286954;25513;25591;63868;24464;24384;294515;314322;25661;25315;116636;24330;140942;25146;497840;81718;114851;25698;24158;312382;25303 zfp36;ugt2b1;pik3r1;parp1;hspd1;hp;gc;foxo3;fos;fn1;ephx1;eif4ebp1;egr1;ddit4;cyp17a1;cps1;cdo1;cdkn1a;ass1;acadm;abcg2;abcc2 ZFP36_10204;UGT2B10_33303,UGT2B1_33224;PIK3R1_32562;PARP1_9425;HSPD1_8849;HP_8823;GC_32893;FOXO3_8662;FOS_8657;FN1_8655;EPHX1_8567;EIF4EBP1_8550;EGR1_8533;DDIT4_8450;CYP17A1_32365;CPS1_32421;CDO1_8275;CDKN1A_8271;ASS1_33159;ACADM_7957;ABCG2_32656;ABCC2_32541 31.88036868181824 26.8889 1.28141E-12 26.212971732172154 32.86632391261604 24.748958620861796 20.195016409090965 21.39075 1.28141E-12 15.7996534261489 20.69291780296221 14.600521069906028 59.8390295454546 39.152950000000004 1.28142E-12 57.0730118781306 58.60976729006652 47.358135198677665 7.5 15.965799999999998 16.5 48.582825 0.348134;47.47345;18.7324;26.9741;42.2579;64.9285;42.356;13.1992;1.28141E-12;59.5777;12.4747;83.9001;0.750017;87.5421;49.6922;31.9826;22.9638;6.24967;26.8037;11.7137;5.21654;46.2316 0.118102;34.82915;11.6701;21.799;23.9469;41.6103;26.3722;5.6804;1.28141E-12;31.0499;7.00435;42.4185;0.186019;53.2453;35.6654;24.4836;18.5144;2.44025;20.9825;8.36151;2.73368;31.1788 1.15962;76.47475;41.5978;35.2797;102.383;136.455;78.7583;32.7581;1.28142E-12;105.243;23.684;107.32;4.70178;245.492;81.6409;45.5891;30.0179;19.0606;36.7081;18.9642;11.386;81.7848 9 14 8 286954;25591;63868;25315;116636;25146;24158;312382 UGT2B10_33303,UGT2B1_33224;PARP1_9425;HSPD1_8849;EPHX1_8567;EIF4EBP1_8550;CYP17A1_32365;ACADM_7957;ABCG2_32656 34.96283625 34.616 26.230963184672706 22.09481125 22.87295 14.90001587296608 57.14156875 55.877224999999996 39.07334670922418 47.47345;26.9741;42.2579;12.4747;83.9001;49.6922;11.7137;5.21654 34.82915;21.799;23.9469;7.00435;42.4185;35.6654;8.36151;2.73368 76.47475;35.2797;102.383;23.684;107.32;81.6409;18.9642;11.386 14 79426;25513;24464;24384;294515;314322;25661;24330;140942;497840;81718;114851;25698;25303 ZFP36_10204;PIK3R1_32562;HP_8823;GC_32893;FOXO3_8662;FOS_8657;FN1_8655;EGR1_8533;DDIT4_8450;CPS1_32421;CDO1_8275;CDKN1A_8271;ASS1_33159;ABCC2_32541 30.118958642857233 24.88375 27.023671753410678 19.109419357142947 19.74845 16.739551616279634 61.3804357142858 39.152950000000004 66.57866602207369 0.348134;18.7324;64.9285;42.356;13.1992;1.28141E-12;59.5777;0.750017;87.5421;31.9826;22.9638;6.24967;26.8037;46.2316 0.118102;11.6701;41.6103;26.3722;5.6804;1.28141E-12;31.0499;0.186019;53.2453;24.4836;18.5144;2.44025;20.9825;31.1788 1.15962;41.5978;136.455;78.7583;32.7581;1.28142E-12;105.243;4.70178;245.492;45.5891;30.0179;19.0606;36.7081;81.7848 0 Exp 2,7(0.31);Exp 3,3(0.14);Exp 4,3(0.14);Hill,4(0.18);Linear,3(0.14);Poly 2,2(0.09);Power,1(0.05) 1.8689861024390015 44.126094460487366 1.5074360370635986 4.21828556060791 0.5488446456274707 1.8086696863174438 20.926664953645634 42.83407240999084 13.592761448985343 26.797271369196594 35.98973579215479 83.68832329875443 DOWN 0.36363636363636365 0.6363636363636364 0.0 GO:1901576 4 organic substance biosynthetic process 397 444 73 73 49 59 38 38 124 406 1979 0.98343 0.026734 0.04183 8.56 293688;65192;246074;25106;298490;83516;303612;24651;25513;81819;294103;100359982;24539;24516;364070;29540;289456;25675;24443;24957;499914;294515;314322;24890;25315;24330;298541;25428;25146;497840;362866;81718;25698;25028;25284;362732;24158;296925 tm7sf2;slc27a2;scd;rgn;ppcs;ppargc1a;polg2;pklr;pik3r1;pax8;papss2;mpc2;lpl;jun;iars2;hsd17b7;hsd17b11;hmgcr;hdc;glul;gins1;foxo3;fos;esr1;ephx1;egr1;dhdds;cyp7a1;cyp17a1;cps1;chpt1;cdo1;ass1;ampd1;amacr;agmo;acadm;aass TM7SF2_10031;SLC27A2_9860;SCD1_9787;RGN_9699;PPCS_9540;PPARGC1A_33189;POLG2_9521;PKLR_9489;PIK3R1_32562;PAX8_9432;PAPSS2_33237;MPC2_33219;LPL_32544;JUN_8938;IARS2_8858;HSD17B7_8834;HSD17B11_8832;HMGCR_8810;HDC_8788;GLUL_32832;GINS1_8707;FOXO3_8662;FOS_8657;ESR1_33192;EPHX1_8567;EGR1_8533;DHDDS_8467;CYP7A1_8430;CYP17A1_32365;CPS1_32421;CHPT1_33298;CDO1_8275;ASS1_33159;AMPD1_32743;AMACR_8038;AGMO_33265;ACADM_7957;AASS_7936 31.957097657894774 24.65245 1.28141E-12 25.680099436067714 34.816354207678344 25.464633478006267 22.895513973684245 20.3923 1.28141E-12 17.783180633477198 25.23802394571428 17.82008672465534 59.89210026315793 36.0692 1.28142E-12 74.50413343405904 62.7650408906431 70.27296315968714 21.5 27.134050000000002 82.3097;7.62189;105.46;77.4407;20.3353;42.4094;63.7758;23.0963;18.7324;56.8931;34.4443;46.8463;74.2041;16.4324;24.7304;0.977494;22.4334;1.63089;24.5745;26.4669;58.9165;13.1992;1.28141E-12;23.3972;12.4747;0.750017;47.9438;5.72128;49.6922;31.9826;16.0559;22.9638;26.8037;60.9045;2.03774;31.5332;11.7137;27.4644 51.1696;5.49916;63.7532;58.7732;16.7643;26.2988;40.9553;17.4625;11.6701;45.1162;25.719;35.8494;49.8682;10.5224;19.8021;0.322682;18.1233;0.663137;21.0619;21.0456;44.7208;5.6804;1.28141E-12;18.3088;7.00435;0.186019;36.5688;0.985273;35.6654;24.4836;10.6021;18.5144;20.9825;50.0633;1.165;24.5474;8.36151;21.7498 209.842;13.3925;422.699;89.8047;25.6711;81.7305;132.567;32.9443;41.5978;81.5688;51.1014;69.127;155.425;39.929;32.7087;5.49472;29.2247;7.6286;29.28;35.4303;91.837;32.7581;1.28142E-12;31.9156;23.684;4.70178;71.3742;22.3625;81.6409;45.5891;29.905;30.0179;36.7081;82.6625;3.73641;43.8459;18.9642;37.0295 20 18 20 65192;246074;25106;298490;81819;100359982;24539;364070;289456;24443;499914;25315;298541;25146;362866;25028;25284;362732;24158;296925 SLC27A2_9860;SCD1_9787;RGN_9699;PPCS_9540;PAX8_9432;MPC2_33219;LPL_32544;IARS2_8858;HSD17B11_8832;HDC_8788;GINS1_8707;EPHX1_8567;DHDDS_8467;CYP17A1_32365;CHPT1_33298;AMPD1_32743;AMACR_8038;AGMO_33265;ACADM_7957;AASS_7936 38.96381650000001 29.498800000000003 27.275553524410103 28.752970999999995 23.148600000000002 18.765859825521602 71.6790555 40.4377 90.41986316868089 7.62189;105.46;77.4407;20.3353;56.8931;46.8463;74.2041;24.7304;22.4334;24.5745;58.9165;12.4747;47.9438;49.6922;16.0559;60.9045;2.03774;31.5332;11.7137;27.4644 5.49916;63.7532;58.7732;16.7643;45.1162;35.8494;49.8682;19.8021;18.1233;21.0619;44.7208;7.00435;36.5688;35.6654;10.6021;50.0633;1.165;24.5474;8.36151;21.7498 13.3925;422.699;89.8047;25.6711;81.5688;69.127;155.425;32.7087;29.2247;29.28;91.837;23.684;71.3742;81.6409;29.905;82.6625;3.73641;43.8459;18.9642;37.0295 18 293688;83516;303612;24651;25513;294103;24516;29540;25675;24957;294515;314322;24890;24330;25428;497840;81718;25698 TM7SF2_10031;PPARGC1A_33189;POLG2_9521;PKLR_9489;PIK3R1_32562;PAPSS2_33237;JUN_8938;HSD17B7_8834;HMGCR_8810;GLUL_32832;FOXO3_8662;FOS_8657;ESR1_33192;EGR1_8533;CYP7A1_8430;CPS1_32421;CDO1_8275;ASS1_33159 24.17185450000007 23.03005 21.95218708436145 16.387228388888957 17.88565 14.473723602555316 46.79548333333341 34.1873 50.97676851242643 82.3097;42.4094;63.7758;23.0963;18.7324;34.4443;16.4324;0.977494;1.63089;26.4669;13.1992;1.28141E-12;23.3972;0.750017;5.72128;31.9826;22.9638;26.8037 51.1696;26.2988;40.9553;17.4625;11.6701;25.719;10.5224;0.322682;0.663137;21.0456;5.6804;1.28141E-12;18.3088;0.186019;0.985273;24.4836;18.5144;20.9825 209.842;81.7305;132.567;32.9443;41.5978;51.1014;39.929;5.49472;7.6286;35.4303;32.7581;1.28142E-12;31.9156;4.70178;22.3625;45.5891;30.0179;36.7081 0 Exp 2,16(0.43);Exp 4,4(0.11);Hill,5(0.14);Linear,8(0.22);Poly 2,5(0.14) 2.0988834822727545 93.33620703220367 1.5504547357559204 17.513065338134766 2.586746766990173 1.8959509134292603 23.792007696310304 40.12218761947925 17.241280817892296 28.549747129476174 36.203214107811455 83.58098641850441 CONFLICT 0.5263157894736842 0.47368421052631576 0.0 GO:0032102 6 negative regulation of response to external stimulus 106 114 12 12 9 11 9 9 153 105 2280 0.81511 0.29812 0.4349 7.89 79426;85253;288001;65164;25675;361969;80841;113936;114851 zfp36;plg;kng1;htra1;hmgcr;fga;fabp7;cpb2;cdkn1a ZFP36_10204;PLG_9501;KNG1L1_34113;HTRA1_8856;HMGCR_8810;FGA_8632;FABP7_8592;CPB2_8369;CDKN1A_8271 23.947232666666668 24.601 0.348134 21.424187057913514 29.867181264917974 24.06092956270946 16.890687666666665 19.538 0.118102 14.782083105738616 20.83833911010018 16.363146197321193 40.72313555555556 34.8042 1.15962 43.834288449481846 53.774816481633835 51.443647680722954 4.5 25.2163 0.348134;70.7857;24.3655;33.1323;1.63089;28.5803;24.601;25.8316;6.24967 0.118102;46.2356;19.538;25.6145;0.663137;22.529;14.4402;20.4374;2.44025 1.15962;150.579;32.1467;46.6629;7.6286;38.8511;35.6155;34.8042;19.0606 1 8 1 80841 FABP7_8592 24.601 24.601 14.4402 14.4402 35.6155 35.6155 24.601 14.4402 35.6155 8 79426;85253;288001;65164;25675;361969;113936;114851 ZFP36_10204;PLG_9501;KNG1L1_34113;HTRA1_8856;HMGCR_8810;FGA_8632;CPB2_8369;CDKN1A_8271 23.865511750000003 25.098550000000003 22.90191972785517 17.196998625 19.9877 15.772146998199336 41.36159000000001 33.47545 46.81606839138765 0.348134;70.7857;24.3655;33.1323;1.63089;28.5803;25.8316;6.24967 0.118102;46.2356;19.538;25.6145;0.663137;22.529;20.4374;2.44025 1.15962;150.579;32.1467;46.6629;7.6286;38.8511;34.8042;19.0606 0 Exp 2,1(0.12);Exp 4,2(0.23);Hill,2(0.23);Linear,4(0.45) 1.742478791001674 15.866115093231201 1.522104263305664 2.3804118633270264 0.2967305565165784 1.5630855560302734 9.950097122163173 37.94436821117017 7.233060037584108 26.548315295749234 12.08473376856075 69.36153734255036 DOWN 0.1111111111111111 0.8888888888888888 0.0 GO:0009812 4 flavonoid metabolic process 5 11 3 3 3 2 2 2 160 9 2376 0.97146 0.15174 0.15174 18.18 83516;29441 ppargc1a;por PPARGC1A_33189;POR_9531 27.4254 27.4254 12.4414 21.190576018598453 26.615280558649644 21.1595823442121 17.394305 17.394305 8.48981 12.592857595083418 16.91287784337246 12.574439080761142 80.483 80.483 79.2355 1.764231419060398 80.4155531231257 1.7616510260551272 0.0 12.4414 0.5 27.4254 42.4094;12.4414 26.2988;8.48981 81.7305;79.2355 0 2 0 2 83516;29441 PPARGC1A_33189;POR_9531 27.4254 27.4254 21.190576018598453 17.394305 17.394305 12.592857595083418 80.483 80.483 1.764231419060398 42.4094;12.4414 26.2988;8.48981 81.7305;79.2355 0 Exp 2,1(0.5);Poly 2,1(0.5) 1.8664090072099868 3.7395511865615845 1.7576230764389038 1.9819281101226807 0.15860761037207557 1.8697755932807922 -1.9432399999999923 56.794039999999995 -0.058505199999999036 34.8471152 78.0379 82.92810000000001 DOWN 0.0 1.0 0.0 GO:0051098 4 regulation of binding 106 113 7 7 6 5 4 4 158 109 2276 0.14197 0.93791 0.31987 3.54 246273;25591;24516;114851 trib3;parp1;jun;cdkn1a TRIB3_10079;PARP1_9425;JUN_8938;CDKN1A_8271 39.4300425 21.70325 6.24967 46.531707130628234 31.154749637007157 40.72767523496937 29.6613125 16.1607 2.44025 37.00971329661028 23.23786605893489 32.49683155326472 59.424324999999996 37.60435 19.0606 56.71236879384574 47.8231006708371 50.005008518714064 108.064;26.9741;16.4324;6.24967 83.8836;21.799;10.5224;2.44025 143.428;35.2797;39.929;19.0606 1 3 1 25591 PARP1_9425 26.9741 26.9741 21.799 21.799 35.2797 35.2797 26.9741 21.799 35.2797 3 246273;24516;114851 TRIB3_10079;JUN_8938;CDKN1A_8271 43.58202333333333 16.4324 56.07464653204363 32.28208333333333 10.5224 44.870565840880964 67.47253333333333 39.929 66.60178088499836 108.064;16.4324;6.24967 83.8836;10.5224;2.44025 143.428;39.929;19.0606 0 Exp 2,1(0.25);Exp 4,1(0.25);Poly 2,2(0.5) 1.7881716212311083 7.186416029930115 1.522104263305664 1.9785058498382568 0.1958480783246903 1.842902958393097 -6.171030488015667 85.03111548801567 -6.608206530678075 65.93083153067808 3.846203582031194 115.00244641796881 DOWN 0.25 0.75 0.0 GO:1903037 7 regulation of leukocyte cell-cell adhesion 100 105 5 5 3 5 3 3 159 102 2283 0.088155 0.96894 0.15461 2.86 63868;246186;25698 hspd1;fgl1;ass1 HSPD1_8849;FGL1_8640;ASS1_33159 28.179099999999995 26.8037 15.4757 13.443970882146406 25.969984920525224 13.718889610123847 18.381066666666666 20.9825 10.2138 7.226693603808962 16.882894600322505 7.630990682604478 56.500566666666664 36.7081 30.4106 39.85991586799115 52.34267880211932 38.53753828566882 42.2579;15.4757;26.8037 23.9469;10.2138;20.9825 102.383;30.4106;36.7081 1 2 1 63868 HSPD1_8849 42.2579 42.2579 23.9469 23.9469 102.383 102.383 42.2579 23.9469 102.383 2 246186;25698 FGL1_8640;ASS1_33159 21.139699999999998 21.139699999999998 8.010105617281218 15.59815 15.59815 7.614620794563583 33.55935 33.55935 4.453004954522223 15.4757;26.8037 10.2138;20.9825 30.4106;36.7081 0 Exp 2,1(0.34);Exp 3,1(0.34);Poly 2,1(0.34) 1.8569270574001555 5.644602179527283 1.511321783065796 2.2518506050109863 0.3702644219835415 1.8814297914505005 12.965814792741966 43.39238520725803 10.203293011546968 26.558840321786363 11.394825680396025 101.6063076529373 DOWN 0.3333333333333333 0.6666666666666666 0.0