PDT Data

Please compare each treatment group to 1% methanol

Caov-3 BPD-PDT Med VC

Table 1 Treatment = NT

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - Media	0.0233007	0.0437211	8	0.5329384	0.6085579

Table 1 Treatment = BPD Only (0.25µM)

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - Media	0.0362299	0.0585457	8	0.6188308	0.5532364

Table 1 Treatment = Light Only (1 J/cm2)

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - Media	0.1440742	0.042307	8	3.405444	0.0092854

Table 1 Treatment = 0.03 J/cm2

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - Media	0.0144042	0.0313277	8	0.4597915	0.6579035

Table 1 Treatment = 0.05 J/cm2

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - Media	0.0495857	0.0506121	8	0.9797199	0.355919

Table 1 Treatment = 0.07 J/cm2

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - Media	-0.0024703	0.0325128	8	-0.0759796	0.941301

Table 1 Treatment = 0.1 J/cm2

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - Media	-0.1123807	0.1222237	8	-0.9194672	0.3847366

Table 1 Treatment = 0.25 J/cm2

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - Media	-0.3694173	0.118795	8	-3.109703	0.014452

Table 1 Treatment = 0.5 J/cm2

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - Media	-0.1944595	0.0471408	7	-4.125082	0.0044312

Table 1 Treatment = 1 J/cm2

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - Media	-0.0487925	0.0264336	7	-1.845854	0.1074185

OVCAR-3 BPD-PDT Med VC

Table 2 Treatment = NT

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - Media	0	0.0403243	8	0	1

Table 2 Treatment = BPD Only (0.25µM)

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - Media	-0.0070188	0.0320371	8	-0.2190822	0.8320721

Table 2 Treatment = Light Only (1 J/cm2)

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - Media	0.043314	0.0453102	8	0.9559424	0.3670923

Table 2 Treatment = 0.03 J/cm2

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - Media	-0.0282246	0.0519228	8	-0.5435866	0.6015409

Table 2 Treatment = 0.05 J/cm2

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - Media	-0.0811775	0.037039	8	-2.191677	0.0597645

Table 2 Treatment = 0.07 J/cm2

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - Media	-0.0643182	0.032347	8	-1.988382	0.0819781

Table 2 Treatment = 0.1 J/cm2

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - Media	-0.0894683	0.052978	8	-1.688784	0.1297354

Table 2 Treatment = 0.25 J/cm2

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - Media	-0.3044683	0.0924804	8	-3.292249	0.0109851

Table 2 Treatment = 0.5 J/cm2

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - Media	-0.0732615	0.0129	8	-5.679194	0.0004654

Table 2 Treatment = 1 J/cm2

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - Media	-0.1079472	0.0425589	8	-2.536421	0.0349047

Caov-3 BPD-PDT + PFOA

Table 3 Env Factor = NT

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFOA	0.1127667	0.0448977	13	2.5116352	0.0513464
1% Methanol - 500nM PFOA	-0.0059807	0.0448977	13	-0.1332081	0.9891983

Table 3 Env Factor = BPD Only (0.25µM)

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFOA	0.0994327	0.0274887	13	3.617225	0.0062445
1% Methanol - 500nM PFOA	0.0903186	0.0274887	13	3.285667	0.0117820

Table 3 Env Factor = Light Only (1 J/cm2)

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFOA	0.1165139	0.0463005	13	2.516472	0.0508859
1% Methanol - 500nM PFOA	0.1174240	0.0463005	13	2.536127	0.0490545

Table 3 Env Factor = 0.03 J/cm2

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFOA	0.0834033	0.0235675	13	3.538908	0.0072524
1% Methanol - 500nM PFOA	0.0662994	0.0235675	13	2.813171	0.0290962

Table 3 Env Factor = 0.05 J/cm2

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFOA	0.1165652	0.0346644	13	3.362675	0.0101641
1% Methanol - 500nM PFOA	0.0725755	0.0346644	13	2.093659	0.1097292

Table 3 Env Factor = 0.07 J/cm2

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFOA	0.0916271	0.0303522	13	3.0188002	0.0196531
1% Methanol - 500nM PFOA	0.0244611	0.0303522	13	0.8059096	0.6805374

Table 3 Env Factor = 0.1 J/cm2

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFOA	0.0567745	0.1352564	13	0.4197546	0.8985698
1% Methanol - 500nM PFOA	0.0154465	0.1352564	13	0.1142017	0.9920474

Table 3 Env Factor = 0.25 J/cm2

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFOA	-0.0060917	0.1361455	13	-0.0447437	0.9987744
1% Methanol - 500nM PFOA	-0.1399209	0.1361455	13	-1.0277308	0.5414273

Table 3 Env Factor = 0.5 J/cm2

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFOA	-0.0086191	0.0116402	13	-0.7404580	0.7214111
1% Methanol - 500nM PFOA	-0.0013279	0.0116402	13	-0.1140763	0.9920648

Table 3 Env Factor = 1 J/cm2

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFOA	-0.0250107	0.022255	13	-1.1238192	0.4836346
1% Methanol - 500nM PFOA	-0.0191902	0.022255	13	-0.8622873	0.6449698

OVCAR-3 BPD-PDT + PFOA

Table 4 Env Factor = NT

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFOA	0.0291711	0.0539363	13	0.5408431	0.8382041
1% Methanol - 500nM PFOA	0.0296411	0.0539363	13	0.5495575	0.8334862

Table 4 Env Factor = BPD Only (0.25µM)

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFOA	-0.1026051	0.0461329	13	-2.2241210	0.0869817
1% Methanol - 500nM PFOA	-0.0085944	0.0461329	13	-0.1862966	0.9790005

Table 4 Env Factor = Light Only (1 J/cm2)

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFOA	0.0513502	0.0711378	13	0.7218413	0.7328913
1% Methanol - 500nM PFOA	0.0417190	0.0711378	13	0.5864538	0.8130431

Table 4 Env Factor = 0.03 J/cm2

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFOA	-0.0015209	0.0628669	13	-0.0241931	0.9996415
1% Methanol - 500nM PFOA	-0.0005286	0.0628669	13	-0.0084088	0.9999567

Table 4 Env Factor = 0.05 J/cm2

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFOA	-0.1027264	0.0788039	13	-1.3035697	0.3837651
1% Methanol - 500nM PFOA	-0.0688788	0.0788039	13	-0.8740523	0.6375350

Table 4 Env Factor = 0.07 J/cm2

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFOA	-0.0502307	0.0680737	13	-0.7378865	0.7230014
1% Methanol - 500nM PFOA	0.0913699	0.0680737	13	1.3422201	0.3639878

Table 4 Env Factor = 0.1 J/cm2

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFOA	-0.0896230	0.1060814	13	-0.8448514	0.6559856
1% Methanol - 500nM PFOA	0.0311439	0.1060814	13	0.2935855	0.9487925

Table 4 Env Factor = 0.25 J/cm2

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFOA	-0.0641821	0.0779581	13	-0.8232896	0.6695925
1% Methanol - 500nM PFOA	-0.1129101	0.0779581	13	-1.4483439	0.3131040

Table 4 Env Factor = 0.5 J/cm2

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFOA	-0.0232053	0.0338472	13	-0.6855885	0.7549903
1% Methanol - 500nM PFOA	-0.0877155	0.0338472	13	-2.5915124	0.0442262

Table 4 Env Factor = 1 J/cm2

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFOA	-0.0001372	0.0454073	13	-0.0030225	0.9999944
1% Methanol - 500nM PFOA	-0.0971491	0.0454073	13	-2.1395029	0.1011859

[1] 5

Caov-3 BPD-PDT + PFHpA

Table 5 Env Factor = NT

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFHpA	0.0539296	0.0302736	13	1.781409	0.1867717
1% Methanol - 500nM PFHpA	0.0869796	0.0302736	13	2.873120	0.0259587

Table 5 Env Factor = BPD Only (0.25µM)

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFHpA	0.1039549	0.0313329	13	3.317757	0.0110785
1% Methanol - 500nM PFHpA	0.1033218	0.0313329	13	3.297552	0.0115164

Table 5 Env Factor = Light Only (1 J/cm2)

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFHpA	0.1203765	0.0334458	13	3.599149	0.0064638
1% Methanol - 500nM PFHpA	0.1350677	0.0334458	13	4.038402	0.0028114

Table 5 Env Factor = 0.03 J/cm2

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFHpA	0.1094596	0.0347605	13	3.148966	0.0153147
1% Methanol - 500nM PFHpA	0.0990278	0.0347605	13	2.848861	0.0271863

Table 5 Env Factor = 0.05 J/cm2

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFHpA	0.1005436	0.0445213	13	2.258328	0.0817763
1% Methanol - 500nM PFHpA	0.1024031	0.0445213	13	2.300094	0.0758102

Table 5 Env Factor = 0.07 J/cm2

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFHpA	0.1110031	0.0517387	13	2.145454	0.1001220
1% Methanol - 500nM PFHpA	0.0519362	0.0517387	13	1.003815	0.5561602

Table 5 Env Factor = 0.1 J/cm2

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFHpA	0.2307416	0.1194414	13	1.931839	0.1452462
1% Methanol - 500nM PFHpA	0.1318661	0.1194414	13	1.104024	0.4953309

Table 5 Env Factor = 0.25 J/cm2

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFHpA	0.0172283	0.0520696	13	0.3308708	0.9354913
1% Methanol - 500nM PFHpA	0.0452249	0.0520696	13	0.8685476	0.6410136

Table 5 Env Factor = 0.5 J/cm2

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFHpA	-0.0040204	0.0102038	13	-0.394011	0.9099759
1% Methanol - 500nM PFHpA	-0.0092519	0.0102038	13	-0.906709	0.6169134

Table 5 Env Factor = 1 J/cm2

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFHpA	-0.0022774	0.0093337	13	-0.2439951	0.9642953
1% Methanol - 500nM PFHpA	-0.0065411	0.0093337	13	-0.7007978	0.7457643

OVCAR-3 BPD-PDT + PFHpA

Table 6 Env Factor = NT

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFHpA	0.0595378	0.0433457	13	1.3735575	0.3484337
1% Methanol - 500nM PFHpA	0.0185219	0.0433457	13	0.4273058	0.8951206

Table 6 Env Factor = BPD Only (0.25µM)

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFHpA	-0.0701214	0.0500359	13	-1.4014204	0.3349735
1% Methanol - 500nM PFHpA	-0.0256378	0.0500359	13	-0.5123874	0.8532910

Table 6 Env Factor = Light Only (1 J/cm2)

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFHpA	0.0193358	0.0649118	13	0.2978786	0.9473312
1% Methanol - 500nM PFHpA	0.0706610	0.0649118	13	1.0885700	0.5045430

Table 6 Env Factor = 0.03 J/cm2

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFHpA	-0.0047680	0.0474692	13	-0.1004431	0.9938417
1% Methanol - 500nM PFHpA	0.0449863	0.0474692	13	0.9476937	0.5911294

Table 6 Env Factor = 0.05 J/cm2

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFHpA	-0.1095554	0.0538413	13	-2.0347832	0.1216459
1% Methanol - 500nM PFHpA	-0.0434257	0.0538413	13	-0.8065493	0.6801350

Table 6 Env Factor = 0.07 J/cm2

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFHpA	-0.0734369	0.0509821	13	-1.4404442	0.3167151
1% Methanol - 500nM PFHpA	-0.0342922	0.0509821	13	-0.6726316	0.7627928

Table 6 Env Factor = 0.1 J/cm2

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFHpA	0.0383861	0.0828263	13	0.4634527	0.8779920
1% Methanol - 500nM PFHpA	0.1007965	0.0828263	13	1.2169615	0.4303539

Table 6 Env Factor = 0.25 J/cm2

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFHpA	-0.3132029	0.1044159	13	-2.9995727	0.0203896
1% Methanol - 500nM PFHpA	-0.0634032	0.1044159	13	-0.6072184	0.8012306

Table 6 Env Factor = 0.5 J/cm2

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFHpA	-0.0104050	0.0090508	13	-1.149625	0.4685726
1% Methanol - 500nM PFHpA	0.0106726	0.0090508	13	1.179190	0.4515918

Table 6 Env Factor = 1 J/cm2

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFHpA	0.0011879	0.0023821	13	0.4986648	0.8603829
1% Methanol - 500nM PFHpA	0.0040804	0.0023821	13	1.7129522	0.2087058

Caov-3 BPD-PDT + PFPA

Table 7 Env Factor = NT

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFPA	-0.0261039	0.0471835	13	-0.5532411	0.8314787
1% Methanol - 500nM PFPA	0.0195793	0.0471835	13	0.4149599	0.9007358

Table 7 Env Factor = BPD Only (0.25µM)

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFPA	-0.0127522	0.0290098	13	-0.4395827	0.8894160
1% Methanol - 500nM PFPA	0.0226864	0.0290098	13	0.7820266	0.6955267

Table 7 Env Factor = Light Only (1 J/cm2)

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFPA	-0.0084034	0.0471929	13	-0.1780658	0.9807945
1% Methanol - 500nM PFPA	0.0313083	0.0471929	13	0.6634103	0.7683114

Table 7 Env Factor = 0.03 J/cm2

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFPA	0.0171375	0.0331779	13	0.516534	0.8511240
1% Methanol - 500nM PFPA	0.0353299	0.0331779	13	1.064863	0.5188045

Table 7 Env Factor = 0.05 J/cm2

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFPA	0.0061593	0.0911272	13	0.0675897	0.9972059
1% Methanol - 500nM PFPA	-0.0512921	0.0911272	13	-0.5628624	0.8261993

Table 7 Env Factor = 0.07 J/cm2

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFPA	0.0967627	0.082319	13	1.1754602	0.4537170
1% Methanol - 500nM PFPA	0.0645390	0.082319	13	0.7840111	0.6942839

Table 7 Env Factor = 0.1 J/cm2

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFPA	0.1609550	0.121219	13	1.3278032	0.3712891
1% Methanol - 500nM PFPA	0.0162241	0.121219	13	0.1338413	0.9890960

Table 7 Env Factor = 0.25 J/cm2

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFPA	-0.1931465	0.0935642	13	-2.0643201	0.1155308
1% Methanol - 500nM PFPA	-0.0780563	0.0935642	13	-0.8342537	0.6626765

Table 7 Env Factor = 0.5 J/cm2

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFPA	-0.0134345	0.0170398	13	-0.7884187	0.6915218
1% Methanol - 500nM PFPA	0.0039558	0.0170398	13	0.2321480	0.9676135

Table 7 Env Factor = 1 J/cm2

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFPA	-0.0288687	0.0159812	13	-1.8064154	0.1792484
1% Methanol - 500nM PFPA	-0.0106976	0.0159812	13	-0.6693848	0.7647393

OVCAR-3 BPD-PDT + PFPA

Table 8 Env Factor = NT

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFPA	0.1018042	0.0579261	13	1.757482	0.1942125
1% Methanol - 500nM PFPA	0.1194635	0.0579261	13	2.062342	0.1159316

Table 8 Env Factor = BPD Only (0.25µM)

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFPA	0.0928932	0.0605695	13	1.533664	0.2759396
1% Methanol - 500nM PFPA	0.1081014	0.0605695	13	1.784750	0.1857516

Table 8 Env Factor = Light Only (1 J/cm2)

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFPA	0.1178452	0.0630353	13	1.869510	0.1613849
1% Methanol - 500nM PFPA	0.0888102	0.0630353	13	1.408895	0.3314225

Table 8 Env Factor = 0.03 J/cm2

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFPA	0.1445953	0.0727603	13	1.987282	0.1320815
1% Methanol - 500nM PFPA	0.1164989	0.0727603	13	1.601133	0.2489307

Table 8 Env Factor = 0.05 J/cm2

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFPA	0.0295725	0.076343	13	0.3873642	0.9128299
1% Methanol - 500nM PFPA	0.0375296	0.076343	13	0.4915920	0.8639892

Table 8 Env Factor = 0.07 J/cm2

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFPA	0.0666505	0.0660711	13	1.0087684	0.5530996
1% Methanol - 500nM PFPA	0.0438865	0.0660711	13	0.6642315	0.7678212

Table 8 Env Factor = 0.1 J/cm2

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFPA	-0.0340966	0.0987062	13	-0.3454350	0.9299302
1% Methanol - 500nM PFPA	0.0150505	0.0987062	13	0.1524773	0.9858751

Table 8 Env Factor = 0.25 J/cm2

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFPA	-0.1212787	0.0692344	13	-1.7517104	0.1960435
1% Methanol - 500nM PFPA	-0.0628472	0.0692344	13	-0.9077443	0.6162605

Table 8 Env Factor = 0.5 J/cm2

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFPA	0.0008066	0.0133161	13	0.0605752	0.9977550
1% Methanol - 500nM PFPA	-0.0050988	0.0133161	13	-0.3829068	0.9147223

Table 8 Env Factor = 1 J/cm2

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFPA	0.0042053	0.0049657	13	0.8468601	0.6547169
1% Methanol - 500nM PFPA	-0.0024654	0.0049657	13	-0.4964822	0.8614993

Caov-3 BPD-PDT + Mix

Table 9 Env Factor = No Treatment

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - (1µM PFHpA + 1µM PFPA)	-0.0642959	0.0754894	23	-0.8517203	0.8731009
1% Methanol - (1µM PFOA + 1µM PFHpA)	-0.0881325	0.0754894	23	-1.1674809	0.6919099
1% Methanol - (1µM PFOA + 1µM PFPA)	-0.0609119	0.0754894	23	-0.8068925	0.8929461
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA)	-0.0895812	0.0754894	23	-1.1866725	0.6793028

Table 9 Env Factor = BPD Only (0.25µM)

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - (1µM PFHpA + 1µM PFPA)	0.0716723	0.0549945	23	1.3032651	0.6013088
1% Methanol - (1µM PFOA + 1µM PFHpA)	-0.0086963	0.0549945	23	-0.1581299	0.9997615
1% Methanol - (1µM PFOA + 1µM PFPA)	0.0308630	0.0549945	23	0.5612024	0.9689088
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA)	0.0673226	0.0549945	23	1.2241699	0.6544216

Table 9 Env Factor = Light Only (1 J/cm2)

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - (1µM PFHpA + 1µM PFPA)	-0.0556935	0.0639269	23	-0.8712052	0.8639277
1% Methanol - (1µM PFOA + 1µM PFHpA)	-0.0872878	0.0639269	23	-1.3654315	0.5595069
1% Methanol - (1µM PFOA + 1µM PFPA)	-0.0514393	0.0639269	23	-0.8046574	0.8938886
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA)	-0.0046950	0.0639269	23	-0.0734426	0.9999888

Table 9 Env Factor = 0.03 J/cm2

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - (1µM PFHpA + 1µM PFPA)	-0.0280821	0.0792102	23	-0.3545262	0.9943779
1% Methanol - (1µM PFOA + 1µM PFHpA)	-0.0230407	0.0792102	23	-0.2908808	0.9973797
1% Methanol - (1µM PFOA + 1µM PFPA)	-0.0763287	0.0792102	23	-0.9636214	0.8162282
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA)	0.0341414	0.0792102	23	0.4310228	0.9882074

Table 9 Env Factor = 0.05 J/cm2

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - (1µM PFHpA + 1µM PFPA)	0.0892046	0.0928672	23	0.9605612	0.8179113
1% Methanol - (1µM PFOA + 1µM PFHpA)	0.0055238	0.0928672	23	0.0594812	0.9999952
1% Methanol - (1µM PFOA + 1µM PFPA)	0.0012967	0.0928672	23	0.0139626	1.0000000
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA)	0.1854728	0.0928672	23	1.9971834	0.2118156

Table 9 Env Factor = 0.07 J/cm2

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - (1µM PFHpA + 1µM PFPA)	0.2359161	0.1022568	23	2.307095	0.1161516
1% Methanol - (1µM PFOA + 1µM PFHpA)	0.0390865	0.1022568	23	0.382239	0.9925078
1% Methanol - (1µM PFOA + 1µM PFPA)	0.1414062	0.1022568	23	1.382854	0.5478543
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA)	0.3228120	0.1022568	23	3.156877	0.0175225

Table 9 Env Factor = 0.1 J/cm2

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - (1µM PFHpA + 1µM PFPA)	0.4653259	0.1297645	23	3.585927	0.0062373
1% Methanol - (1µM PFOA + 1µM PFHpA)	0.4318824	0.1297645	23	3.328203	0.0116470
1% Methanol - (1µM PFOA + 1µM PFPA)	0.5142685	0.1297645	23	3.963092	0.0024638
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA)	0.5338987	0.1297645	23	4.114368	0.0016922

Table 9 Env Factor = 0.25 J/cm2

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - (1µM PFHpA + 1µM PFPA)	0.2136018	0.0237664	23	8.987567	0e+00
1% Methanol - (1µM PFOA + 1µM PFHpA)	0.1978639	0.0237664	23	8.325373	1e-07
1% Methanol - (1µM PFOA + 1µM PFPA)	0.2104446	0.0237664	23	8.854724	0e+00
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA)	0.2193944	0.0237664	23	9.231298	0e+00

Table 9 Env Factor = 0.5 J/cm2

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - (1µM PFHpA + 1µM PFPA)	0.0709634	0.0106261	23	6.678197	3.3e-06
1% Methanol - (1µM PFOA + 1µM PFHpA)	0.0683286	0.0106261	23	6.430246	5.8e-06
1% Methanol - (1µM PFOA + 1µM PFPA)	0.0704303	0.0106261	23	6.628031	3.7e-06
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA)	0.0735039	0.0106261	23	6.917278	1.9e-06

Table 9 Env Factor = 1 J/cm2

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - (1µM PFHpA + 1µM PFPA)	0.0322277	0.004648	23	6.933682	1.8e-06
1% Methanol - (1µM PFOA + 1µM PFHpA)	0.0311418	0.004648	23	6.700042	3.1e-06
1% Methanol - (1µM PFOA + 1µM PFPA)	0.0312988	0.004648	23	6.733819	2.9e-06
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA)	0.0374865	0.004648	23	8.065079	1.0e-07

OVCAR-3 BPD-PDT + Mix

Table 10 Env Factor = No Treatment

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - (1µM PFHpA + 1µM PFPA)	-0.1179821	0.0668679	23	-1.7644060	0.3170862
1% Methanol - (1µM PFOA + 1µM PFHpA)	-0.1291844	0.0668679	23	-1.9319346	0.2382721
1% Methanol - (1µM PFOA + 1µM PFPA)	-0.1332205	0.0668679	23	-1.9922944	0.2137167
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA)	0.0254508	0.0668679	23	0.3806127	0.9926283

Table 10 Env Factor = BPD Only (0.25µM)

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - (1µM PFHpA + 1µM PFPA)	-0.1239091	0.063266	23	-1.9585432	0.2271989
1% Methanol - (1µM PFOA + 1µM PFHpA)	-0.0197809	0.063266	23	-0.3126624	0.9965335
1% Methanol - (1µM PFOA + 1µM PFPA)	-0.1705348	0.063266	23	-2.6955224	0.0506463
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA)	-0.0438181	0.063266	23	-0.6926010	0.9352165

Table 10 Env Factor = Light Only (1 J/cm2)

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - (1µM PFHpA + 1µM PFPA)	-0.1466851	0.0858994	23	-1.707638	0.3473017
1% Methanol - (1µM PFOA + 1µM PFHpA)	-0.1632728	0.0858994	23	-1.900743	0.2517555
1% Methanol - (1µM PFOA + 1µM PFPA)	-0.1179597	0.0858994	23	-1.373230	0.5542862
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA)	-0.0430325	0.0858994	23	-0.500964	0.9794015

Table 10 Env Factor = 0.03 J/cm2

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - (1µM PFHpA + 1µM PFPA)	-0.1216791	0.0744048	23	-1.6353668	0.3881808
1% Methanol - (1µM PFOA + 1µM PFHpA)	-0.0718824	0.0744048	23	-0.9660992	0.8148605
1% Methanol - (1µM PFOA + 1µM PFPA)	-0.0377485	0.0744048	23	-0.5073392	0.9784255
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA)	-0.0309943	0.0744048	23	-0.4165638	0.9896264

Table 10 Env Factor = 0.05 J/cm2

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - (1µM PFHpA + 1µM PFPA)	-0.0848946	0.1346308	23	-0.6305731	0.9530597
1% Methanol - (1µM PFOA + 1µM PFHpA)	-0.0538758	0.1346308	23	-0.4001740	0.9910848
1% Methanol - (1µM PFOA + 1µM PFPA)	-0.0574933	0.1346308	23	-0.4270442	0.9886106
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA)	-0.0883055	0.1346308	23	-0.6559082	0.9462007

Table 10 Env Factor = 0.07 J/cm2

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - (1µM PFHpA + 1µM PFPA)	0.1484958	0.1112916	23	1.334294	0.5804149
1% Methanol - (1µM PFOA + 1µM PFHpA)	0.1971829	0.1112916	23	1.771767	0.3132953
1% Methanol - (1µM PFOA + 1µM PFPA)	0.2006168	0.1112916	23	1.802623	0.2977292
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA)	0.1231068	0.1112916	23	1.106164	0.7313986

Table 10 Env Factor = 0.1 J/cm2

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - (1µM PFHpA + 1µM PFPA)	0.4685486	0.0965048	23	4.855182	0.0002673
1% Methanol - (1µM PFOA + 1µM PFHpA)	0.4226822	0.0965048	23	4.379907	0.0008733
1% Methanol - (1µM PFOA + 1µM PFPA)	0.4828945	0.0965048	23	5.003837	0.0001848
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA)	0.3532236	0.0965048	23	3.660164	0.0052012

Table 10 Env Factor = 0.25 J/cm2

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - (1µM PFHpA + 1µM PFPA)	0.1161599	0.0362166	23	3.207365	0.0155456
1% Methanol - (1µM PFOA + 1µM PFHpA)	0.0964106	0.0362166	23	2.662056	0.0545474
1% Methanol - (1µM PFOA + 1µM PFPA)	0.1150119	0.0362166	23	3.175669	0.0167600
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA)	0.1192349	0.0362166	23	3.292273	0.0126950

Table 10 Env Factor = 0.5 J/cm2

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - (1µM PFHpA + 1µM PFPA)	-0.0284982	0.020358	23	-1.3998508	0.5365308
1% Methanol - (1µM PFOA + 1µM PFHpA)	-0.0070311	0.020358	23	-0.3453736	0.9949142
1% Methanol - (1µM PFOA + 1µM PFPA)	-0.0120757	0.020358	23	-0.5931675	0.9621282
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA)	-0.0181642	0.020358	23	-0.8922397	0.8536659

Table 10 Env Factor = 1 J/cm2

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - (1µM PFHpA + 1µM PFPA)	0.0009792	0.007311	23	0.133932	0.9998767
1% Methanol - (1µM PFOA + 1µM PFHpA)	0.0084477	0.007311	23	1.155480	0.6997402
1% Methanol - (1µM PFOA + 1µM PFPA)	0.0074407	0.007311	23	1.017736	0.7854182
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA)	-0.0098389	0.007311	23	-1.345770	0.5726994

Caov-3 ALA-PDT Med VC

Table 11 Treatment = 0

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - Media	-0.0641104	0.0395612	20	-1.620535	0.1207781

Table 11 Treatment = ALA Only

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - Media	-0.0106708	0.0336712	20	-0.3169105	0.7545958

Table 11 Treatment = Light Only (25 J)

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - Media	-0.0369194	0.0452653	20	-0.815622	0.4243239

Table 11 Treatment = 1

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - Media	0.001671	0.0414482	20	0.0403154	0.9682414

Table 11 Treatment = 2.5

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - Media	-0.0385495	0.03504	20	-1.100157	0.28433

Table 11 Treatment = 5

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - Media	0.1784037	0.0649824	20	2.745418	0.0124714

Table 11 Treatment = 10

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - Media	0.2134322	0.027446	20	7.776428	2e-07

Table 11 Treatment = 15

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - Media	0.0913599	0.0118994	20	7.677687	2e-07

Table 11 Treatment = 20

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - Media	0.0243709	0.0132038	20	1.845747	0.0797858

Table 11 Treatment = 25

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - Media	0.0308548	0.0075341	20	4.09533	0.0005629

Caov-3 ALA-PDT + PFOA

Table 12 Env Factor = 0

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFOA	0.0979773	0.0404451	13	2.4224746	0.0605778
1% Methanol - 500nM PFOA	0.0260768	0.0404451	13	0.6447455	0.7793873

Table 12 Env Factor = ALA Only

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFOA	0.0369797	0.02945	13	1.2556771	0.4091517
1% Methanol - 500nM PFOA	0.0178052	0.02945	13	0.6045888	0.8027379

Table 12 Env Factor = Light Only (25 J)

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFOA	-0.0526236	0.0280575	13	-1.8755627	0.1597533
1% Methanol - 500nM PFOA	0.0114088	0.0280575	13	0.4066219	0.9044576

Table 12 Env Factor = 1

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFOA	0.0106565	0.0310093	13	0.3436542	0.9306209
1% Methanol - 500nM PFOA	0.0314590	0.0310093	13	1.0145015	0.5495628

Table 12 Env Factor = 2.5

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFOA	-0.0640133	0.0477964	13	-1.3392926	0.3654630
1% Methanol - 500nM PFOA	0.0144442	0.0477964	13	0.3022025	0.9458406

Table 12 Env Factor = 5

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFOA	-0.1328043	0.0960601	13	-1.3825129	0.3440693
1% Methanol - 500nM PFOA	0.0293194	0.0960601	13	0.3052191	0.9447897

Table 12 Env Factor = 10

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFOA	-0.0986017	0.1251792	13	-0.7876847	0.6919820
1% Methanol - 500nM PFOA	-0.0026514	0.1251792	13	-0.0211810	0.9997252

Table 12 Env Factor = 15

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFOA	-0.1303623	0.0787896	13	-1.6545622	0.2290149
1% Methanol - 500nM PFOA	-0.0393373	0.0787896	13	-0.4992697	0.8600729

Table 12 Env Factor = 20

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFOA	-0.0807143	0.0431146	13	-1.8720870	0.1606885
1% Methanol - 500nM PFOA	-0.0074557	0.0431146	13	-0.1729279	0.9818752

Table 12 Env Factor = 25

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFOA	-0.0527912	0.0323322	13	-1.6327737	0.2369811
1% Methanol - 500nM PFOA	0.0060557	0.0323322	13	0.1872969	0.9787772

Caov-3 ALA-PDT + PFHpA

Table 13 Env Factor = 0

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFHpA	-0.0219197	0.0348379	13	-0.6291906	0.7885140
1% Methanol - 500nM PFHpA	-0.0323294	0.0348379	13	-0.9279949	0.6035034

Table 13 Env Factor = ALA Only

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFHpA	-0.0291813	0.0458313	13	-0.6367102	0.7841143
1% Methanol - 500nM PFHpA	-0.0080990	0.0458313	13	-0.1767131	0.9810819

Table 13 Env Factor = Light Only (25 J)

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFHpA	-0.1328881	0.0492593	13	-2.697729	0.0362119
1% Methanol - 500nM PFHpA	-0.1099927	0.0492593	13	-2.232934	0.0856122

Table 13 Env Factor = 1

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFHpA	-0.0565544	0.0387514	13	-1.4594159	0.3080912
1% Methanol - 500nM PFHpA	-0.0201769	0.0387514	13	-0.5206756	0.8489486

Table 13 Env Factor = 2.5

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFHpA	-0.0978517	0.0523049	13	-1.870793	0.1610378
1% Methanol - 500nM PFHpA	-0.0945986	0.0523049	13	-1.808599	0.1786036

Table 13 Env Factor = 5

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFHpA	-0.1672113	0.0951493	13	-1.757357	0.1942520
1% Methanol - 500nM PFHpA	-0.2089265	0.0951493	13	-2.195776	0.0915233

Table 13 Env Factor = 10

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFHpA	-0.0206800	0.0952268	13	-0.2171657	0.9715910
1% Methanol - 500nM PFHpA	0.0183768	0.0952268	13	0.1929788	0.9774873

Table 13 Env Factor = 15

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFHpA	-0.0107942	0.0552732	13	-0.1952879	0.9769527
1% Methanol - 500nM PFHpA	-0.0100726	0.0552732	13	-0.1822337	0.9798957

Table 13 Env Factor = 20

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFHpA	-0.0395873	0.0311376	13	-1.271365	0.4007314
1% Methanol - 500nM PFHpA	-0.0130527	0.0311376	13	-0.419195	0.8988235

Table 13 Env Factor = 25

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFHpA	-0.0248074	0.0293453	13	-0.8453624	0.6556629
1% Methanol - 500nM PFHpA	-0.0117555	0.0293453	13	-0.4005925	0.9071127

Caov-3 ALA-PDT + PFPA

Table 14 Env Factor = 0

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFPA	-0.0415571	0.0345475	13	-1.202898	0.4381994
1% Methanol - 500nM PFPA	0.0348138	0.0345475	13	1.007710	0.5537534

Table 14 Env Factor = ALA Only

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFPA	-0.0395402	0.0359452	13	-1.1000143	0.4977144
1% Methanol - 500nM PFPA	0.0301650	0.0359452	13	0.8391949	0.6595575

Table 14 Env Factor = Light Only (25 J)

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFPA	-0.0864005	0.0728492	13	-1.1860187	0.4477131
1% Methanol - 500nM PFPA	-0.0577854	0.0728492	13	-0.7932195	0.6885104

Table 14 Env Factor = 1

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFPA	0.0185019	0.0330431	13	0.5599316	0.8278130
1% Methanol - 500nM PFPA	0.0393760	0.0330431	13	1.1916558	0.4445242

Table 14 Env Factor = 2.5

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFPA	-0.0547831	0.0339405	13	-1.6140915	0.2439819
1% Methanol - 500nM PFPA	-0.0222413	0.0339405	13	-0.6553015	0.7731393

Table 14 Env Factor = 5

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFPA	-0.1411664	0.0778089	13	-1.8142707	0.1769378
1% Methanol - 500nM PFPA	0.0054860	0.0778089	13	0.0705058	0.9969600

Table 14 Env Factor = 10

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFPA	-0.0842117	0.1148763	13	-0.7330638	0.7259803
1% Methanol - 500nM PFPA	0.0028150	0.1148763	13	0.0245048	0.9996322

Table 14 Env Factor = 15

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFPA	-0.0997628	0.0698142	13	-1.4289758	0.3220086
1% Methanol - 500nM PFPA	-0.0511462	0.0698142	13	-0.7326044	0.7262638

Table 14 Env Factor = 20

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFPA	-0.0667634	0.0384819	13	-1.7349303	0.2014466
1% Methanol - 500nM PFPA	-0.0298382	0.0384819	13	-0.7753824	0.6996835

Table 14 Env Factor = 25

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFPA	-0.0392896	0.0324043	13	-1.2124816	0.4328449
1% Methanol - 500nM PFPA	-0.0276270	0.0324043	13	-0.8525738	0.6511075

OVCAR-3 ALA-PDT Med VC

Table 15 Treatment = 0

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - Media	-0.0422626	0.0395015	26	-1.069897	0.294498

Table 15 Treatment = ALA Only

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - Media	0.0624483	0.0343095	26	1.820147	0.0802683

Table 15 Treatment = Light Only (25 J)

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - Media	0.0719961	0.0432999	26	1.662732	0.1083765

Table 15 Treatment = 1

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - Media	0.1280113	0.0373705	26	3.425464	0.0020488

Table 15 Treatment = 2.5

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - Media	0.1948819	0.0346624	26	5.622285	6.6e-06

Table 15 Treatment = 5

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - Media	0.2529004	0.0395266	26	6.398237	9e-07

Table 15 Treatment = 10

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - Media	0.4878706	0.0442636	26	11.02193	0

Table 15 Treatment = 15

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - Media	0.6147282	0.0483638	26	12.71049	0

Table 15 Treatment = 20

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - Media	0.4853157	0.0440885	26	11.00776	0

Table 15 Treatment = 25

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - Media	0.2890271	0.0319588	26	9.043741	0

OVCAR-3 ALA-PDT + PFOA

Table 16 Env Factor = 0

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFOA	-0.0040792	0.0655894	19	-0.0621932	0.9976047
1% Methanol - 500nM PFOA	-0.1301036	0.0655894	19	-1.9836072	0.1200433

Table 16 Env Factor = ALA Only

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFOA	-0.0417645	0.0593285	19	-0.7039538	0.739900
1% Methanol - 500nM PFOA	-0.0508804	0.0593285	19	-0.8576050	0.642156

Table 16 Env Factor = Light Only (25 J)

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFOA	0.0584860	0.0718819	19	0.8136399	0.6704446
1% Methanol - 500nM PFOA	0.1090151	0.0718819	19	1.5165869	0.2703988

Table 16 Env Factor = 1

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFOA	-0.0239739	0.0807501	19	-0.2968895	0.9469951
1% Methanol - 500nM PFOA	0.0534113	0.0807501	19	0.6614386	0.7660081

Table 16 Env Factor = 2.5

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFOA	-0.0123641	0.0527918	19	-0.2342058	0.9666318
1% Methanol - 500nM PFOA	0.0463424	0.0527918	19	0.8778337	0.6291185

Table 16 Env Factor = 5

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFOA	-0.0553198	0.0656328	19	-0.8428690	0.6516490
1% Methanol - 500nM PFOA	0.0172430	0.0656328	19	0.2627199	0.9582182

Table 16 Env Factor = 10

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFOA	-0.0791463	0.0728333	19	-1.0866779	0.4969980
1% Methanol - 500nM PFOA	-0.0072084	0.0728333	19	-0.0989717	0.9939468

Table 16 Env Factor = 15

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFOA	-0.0111560	0.0906035	19	-0.1231302	0.9906486
1% Methanol - 500nM PFOA	0.0196042	0.0906035	19	0.2163740	0.9714398

Table 16 Env Factor = 20

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFOA	-0.1297296	0.0878303	19	-1.4770479	0.2877429
1% Methanol - 500nM PFOA	-0.0671399	0.0878303	19	-0.7644279	0.7018863

Table 16 Env Factor = 25

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFOA	-0.1435940	0.0621791	19	-2.309364	0.0636067
1% Methanol - 500nM PFOA	-0.0858571	0.0621791	19	-1.380804	0.3331106

OVCAR-3 ALA-PDT + PFHpA

Table 17 Env Factor = 0

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFHpA	-0.1153406	0.0440429	19	-2.618825	0.0334989
1% Methanol - 500nM PFHpA	-0.0486581	0.0440429	19	-1.104791	0.4859757

Table 17 Env Factor = ALA Only

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFHpA	-0.1381871	0.0558304	19	-2.475121	0.0452934
1% Methanol - 500nM PFHpA	-0.0616230	0.0558304	19	-1.103754	0.4866040

Table 17 Env Factor = Light Only (25 J)

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFHpA	0.0139617	0.0738207	19	0.1891293	0.9780952
1% Methanol - 500nM PFHpA	0.1266142	0.0738207	19	1.7151588	0.1946374

Table 17 Env Factor = 1

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFHpA	-0.0586972	0.0619575	19	-0.9473780	0.5844144
1% Methanol - 500nM PFHpA	-0.0500266	0.0619575	19	-0.8074345	0.6744262

Table 17 Env Factor = 2.5

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFHpA	-0.0652192	0.0547043	19	-1.1922148	0.4342782
1% Methanol - 500nM PFHpA	-0.0227462	0.0547043	19	-0.4158036	0.8990110

Table 17 Env Factor = 5

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFHpA	-0.0826768	0.0649496	19	-1.272938	0.3890953
1% Methanol - 500nM PFHpA	-0.0656427	0.0649496	19	-1.010671	0.5442027

Table 17 Env Factor = 10

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFHpA	-0.1193492	0.0682011	19	-1.7499614	0.1832508
1% Methanol - 500nM PFHpA	-0.0607702	0.0682011	19	-0.8910443	0.6206061

Table 17 Env Factor = 15

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFHpA	-0.1339999	0.0825458	19	-1.6233410	0.2273442
1% Methanol - 500nM PFHpA	-0.0328832	0.0825458	19	-0.3983632	0.9068551

Table 17 Env Factor = 20

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFHpA	-0.1883183	0.0771153	19	-2.442033	0.0485067
1% Methanol - 500nM PFHpA	-0.0910761	0.0771153	19	-1.181038	0.4407371

Table 17 Env Factor = 25

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFHpA	-0.1636843	0.0600345	19	-2.726503	0.026620
1% Methanol - 500nM PFHpA	-0.1219468	0.0600345	19	-2.031278	0.109722

OVCAR-3 ALA-PDT + PFPA

Table 18 Env Factor = 0

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFPA	-0.0689919	0.052353	19	-1.317821	0.3651623
1% Methanol - 500nM PFPA	-0.0885568	0.052353	19	-1.691531	0.2026807

Table 18 Env Factor = ALA Only

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFPA	-0.0748578	0.0703964	19	-1.063375	0.5113162
1% Methanol - 500nM PFPA	-0.1562762	0.0703964	19	-2.219945	0.0760693

Table 18 Env Factor = Light Only (25 J)

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFPA	-0.1135310	0.0769412	19	-1.475555	0.2884125
1% Methanol - 500nM PFPA	-0.1043904	0.0769412	19	-1.356755	0.3451328

Table 18 Env Factor = 1

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFPA	-0.1565984	0.0716511	19	-2.185569	0.0814153
1% Methanol - 500nM PFPA	-0.2978128	0.0716511	19	-4.156431	0.0010718

Table 18 Env Factor = 2.5

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFPA	-0.2212689	0.0771949	19	-2.866366	0.0196658
1% Methanol - 500nM PFPA	-0.1286173	0.0771949	19	-1.666137	0.2116114

Table 18 Env Factor = 5

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFPA	-0.2103315	0.0717169	19	-2.932804	0.0170062
1% Methanol - 500nM PFPA	-0.1456910	0.0717169	19	-2.031475	0.1096809

Table 18 Env Factor = 10

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFPA	-0.1271980	0.0854186	19	-1.489114	0.2823698
1% Methanol - 500nM PFPA	-0.1467171	0.0854186	19	-1.717625	0.1938126

Table 18 Env Factor = 15

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFPA	-0.1372437	0.0883128	19	-1.554064	0.2546585
1% Methanol - 500nM PFPA	-0.2889688	0.0883128	19	-3.272106	0.0080027

Table 18 Env Factor = 20

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFPA	-0.1531234	0.0798657	19	-1.917263	0.1357800
1% Methanol - 500nM PFPA	-0.1638526	0.0798657	19	-2.051603	0.1055596

Table 18 Env Factor = 25

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFPA	-0.1566736	0.052989	19	-2.956717	0.0161362
1% Methanol - 500nM PFPA	-0.2020002	0.052989	19	-3.812112	0.0023522

Caov-3 ALA-PDT + PFAS Mixtures

Table 19 Env Factor = 0

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - (1µM PFHpA + 1µM PFPA)	-0.0352918	0.0417159	23	-0.8460036	0.8757303
1% Methanol - (1µM PFOA + 1µM PFHpA)	-0.0199325	0.0417159	23	-0.4778154	0.9826926
1% Methanol - (1µM PFOA + 1µM PFPA)	-0.0614907	0.0417159	23	-1.4740342	0.4878206
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA)	-0.0118820	0.0417159	23	-0.2848321	0.9975851

Table 19 Env Factor = ALA Only

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - (1µM PFHpA + 1µM PFPA)	-0.0238273	0.035722	23	-0.6670217	0.9430058
1% Methanol - (1µM PFOA + 1µM PFHpA)	0.0135902	0.035722	23	0.3804432	0.9926408
1% Methanol - (1µM PFOA + 1µM PFPA)	-0.0616044	0.035722	23	-1.7245515	0.3381197
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA)	-0.0205503	0.035722	23	-0.5752851	0.9660291

Table 19 Env Factor = Light Only (25 J)

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - (1µM PFHpA + 1µM PFPA)	-0.1645832	0.0734827	23	-2.2397551	0.1330576
1% Methanol - (1µM PFOA + 1µM PFHpA)	-0.0480637	0.0734827	23	-0.6540821	0.9467147
1% Methanol - (1µM PFOA + 1µM PFPA)	-0.1131890	0.0734827	23	-1.5403497	0.4456319
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA)	-0.0907168	0.0734827	23	-1.2345334	0.6474990

Table 19 Env Factor = 1

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - (1µM PFHpA + 1µM PFPA)	-0.0429626	0.0512309	23	-0.8386067	0.8790902
1% Methanol - (1µM PFOA + 1µM PFHpA)	-0.0247156	0.0512309	23	-0.4824361	0.9820667
1% Methanol - (1µM PFOA + 1µM PFPA)	-0.0895102	0.0512309	23	-1.7471919	0.3260662
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA)	-0.0425895	0.0512309	23	-0.8313248	0.8823508

Table 19 Env Factor = 2.5

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - (1µM PFHpA + 1µM PFPA)	-0.1400589	0.0580313	23	-2.413504	0.0932139
1% Methanol - (1µM PFOA + 1µM PFHpA)	-0.1245709	0.0580313	23	-2.146615	0.1598249
1% Methanol - (1µM PFOA + 1µM PFPA)	-0.2014131	0.0580313	23	-3.470764	0.0082557
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA)	-0.1485551	0.0580313	23	-2.559911	0.0682163

Table 19 Env Factor = 5

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - (1µM PFHpA + 1µM PFPA)	-0.2746824	0.0690895	23	-3.975747	0.0023877
1% Methanol - (1µM PFOA + 1µM PFHpA)	-0.3107729	0.0690895	23	-4.498119	0.0006504
1% Methanol - (1µM PFOA + 1µM PFPA)	-0.3246183	0.0690895	23	-4.698518	0.0003947
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA)	-0.2557185	0.0690895	23	-3.701263	0.0047022

Table 19 Env Factor = 10

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - (1µM PFHpA + 1µM PFPA)	-0.5355286	0.1161747	23	-4.609684	0.0004924
1% Methanol - (1µM PFOA + 1µM PFHpA)	-0.5131446	0.1161747	23	-4.417009	0.0007962
1% Methanol - (1µM PFOA + 1µM PFPA)	-0.5794142	0.1161747	23	-4.987440	0.0001925
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA)	-0.5437478	0.1161747	23	-4.680433	0.0004129

Table 19 Env Factor = 15

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - (1µM PFHpA + 1µM PFPA)	-0.6294183	0.1322066	23	-4.760869	0.0003379
1% Methanol - (1µM PFOA + 1µM PFHpA)	-0.6375104	0.1322066	23	-4.822077	0.0002902
1% Methanol - (1µM PFOA + 1µM PFPA)	-0.6958974	0.1322066	23	-5.263712	0.0000972
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA)	-0.6288169	0.1322066	23	-4.756320	0.0003418

Table 19 Env Factor = 20

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - (1µM PFHpA + 1µM PFPA)	-0.6058996	0.1232077	23	-4.917710	0.0002288
1% Methanol - (1µM PFOA + 1µM PFHpA)	-0.5815343	0.1232077	23	-4.719953	0.0003742
1% Methanol - (1µM PFOA + 1µM PFPA)	-0.6631489	0.1232077	23	-5.382367	0.0000726
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA)	-0.6410722	0.1232077	23	-5.203184	0.0001129

Table 19 Env Factor = 25

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - (1µM PFHpA + 1µM PFPA)	-0.5207697	0.1025368	23	-5.078858	0.0001535
1% Methanol - (1µM PFOA + 1µM PFHpA)	-0.4594157	0.1025368	23	-4.480497	0.0006796
1% Methanol - (1µM PFOA + 1µM PFPA)	-0.5453682	0.1025368	23	-5.318758	0.0000849
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA)	-0.5548226	0.1025368	23	-5.410962	0.0000677

OVCAR-3 ALA-PDT + PFAS Mixtures

Table 20 Env Factor = 0

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - (1µM PFHpA + 1µM PFPA)	-0.1524139	0.0706827	35	-2.1563101	0.1435993
1% Methanol - (1µM PFOA + 1µM PFHpA)	-0.1332222	0.0706827	35	-1.8847919	0.2447904
1% Methanol - (1µM PFOA + 1µM PFPA)	-0.0648846	0.0706827	35	-0.9179693	0.8373254
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA)	0.0185488	0.0706827	35	0.2624238	0.9982178

Table 20 Env Factor = ALA Only

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - (1µM PFHpA + 1µM PFPA)	-0.1204027	0.067565	35	-1.7820288	0.2942084
1% Methanol - (1µM PFOA + 1µM PFHpA)	-0.1291838	0.067565	35	-1.9119942	0.2327530
1% Methanol - (1µM PFOA + 1µM PFPA)	-0.0842675	0.067565	35	-1.2472065	0.6309932
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA)	-0.0506937	0.067565	35	-0.7502955	0.9137608

Table 20 Env Factor = Light Only (25 J)

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - (1µM PFHpA + 1µM PFPA)	-0.0959286	0.0662771	35	-1.4473853	0.4942286
1% Methanol - (1µM PFOA + 1µM PFHpA)	-0.0362737	0.0662771	35	-0.5473033	0.9710871
1% Methanol - (1µM PFOA + 1µM PFPA)	-0.0840858	0.0662771	35	-1.2686992	0.6162293
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA)	0.0221160	0.0662771	35	0.3336902	0.9954726

Table 20 Env Factor = 1

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - (1µM PFHpA + 1µM PFPA)	-0.1190116	0.0648019	35	-1.836545	0.2672165
1% Methanol - (1µM PFOA + 1µM PFHpA)	-0.1559643	0.0648019	35	-2.406785	0.0832887
1% Methanol - (1µM PFOA + 1µM PFPA)	-0.1082359	0.0648019	35	-1.670258	0.3548793
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA)	-0.1036542	0.0648019	35	-1.599556	0.3967166

Table 20 Env Factor = 2.5

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - (1µM PFHpA + 1µM PFPA)	-0.1942611	0.0602889	35	-3.2221727	0.0109565
1% Methanol - (1µM PFOA + 1µM PFHpA)	-0.0968710	0.0602889	35	-1.6067820	0.3923269
1% Methanol - (1µM PFOA + 1µM PFPA)	-0.0847490	0.0602889	35	-1.4057161	0.5222619
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA)	-0.0314653	0.0602889	35	-0.5219084	0.9756615

Table 20 Env Factor = 5

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - (1µM PFHpA + 1µM PFPA)	-0.1759057	0.0626425	35	-2.808087	0.0319906
1% Methanol - (1µM PFOA + 1µM PFHpA)	-0.1200072	0.0626425	35	-1.915747	0.2311265
1% Methanol - (1µM PFOA + 1µM PFPA)	-0.0857097	0.0626425	35	-1.368236	0.5477865
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA)	-0.0345143	0.0626425	35	-0.550972	0.9703823

Table 20 Env Factor = 10

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - (1µM PFHpA + 1µM PFPA)	-0.2283646	0.070908	35	-3.220578	0.0110033
1% Methanol - (1µM PFOA + 1µM PFHpA)	-0.1260750	0.070908	35	-1.778009	0.2962675
1% Methanol - (1µM PFOA + 1µM PFPA)	-0.1791792	0.070908	35	-2.526926	0.0631645
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA)	-0.1009560	0.070908	35	-1.423761	0.5100708

Table 20 Env Factor = 15

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - (1µM PFHpA + 1µM PFPA)	-0.0726390	0.0732649	35	-0.9914568	0.7963968
1% Methanol - (1µM PFOA + 1µM PFHpA)	-0.0596480	0.0732649	35	-0.8141405	0.8876673
1% Methanol - (1µM PFOA + 1µM PFPA)	-0.0952799	0.0732649	35	-1.3004844	0.5943451
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA)	0.0493384	0.0732649	35	0.6734240	0.9400115

Table 20 Env Factor = 20

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - (1µM PFHpA + 1µM PFPA)	-0.0933796	0.0647766	35	-1.441566	0.4981177
1% Methanol - (1µM PFOA + 1µM PFHpA)	-0.1542739	0.0647766	35	-2.381632	0.0881492
1% Methanol - (1µM PFOA + 1µM PFPA)	-0.1140989	0.0647766	35	-1.761423	0.3048625
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA)	0.0661260	0.0647766	35	1.020833	0.7789758

Table 20 Env Factor = 25

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - (1µM PFHpA + 1µM PFPA)	-0.1788673	0.0635622	35	-2.8140523	0.0315178
1% Methanol - (1µM PFOA + 1µM PFHpA)	-0.1631865	0.0635622	35	-2.5673525	0.0574357
1% Methanol - (1µM PFOA + 1µM PFPA)	-0.1634161	0.0635622	35	-2.5709644	0.0569471
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA)	-0.0466501	0.0635622	35	-0.7339279	0.9198257