Please compare each treatment group to 1% methanol

Caov-3 BPD-PDT Med VC

Table 1 Treatment = NT
contrast estimate SE df t.ratio p.value
1% Methanol - Media 0.0233007 0.0437211 8 0.5329384 0.6085579
Table 1 Treatment = BPD Only (0.25µM)
contrast estimate SE df t.ratio p.value
1% Methanol - Media 0.0362299 0.0585457 8 0.6188308 0.5532364
Table 1 Treatment = Light Only (1 J/cm2)
contrast estimate SE df t.ratio p.value
1% Methanol - Media 0.1440742 0.042307 8 3.405444 0.0092854
Table 1 Treatment = 0.03 J/cm2
contrast estimate SE df t.ratio p.value
1% Methanol - Media 0.0144042 0.0313277 8 0.4597915 0.6579035
Table 1 Treatment = 0.05 J/cm2
contrast estimate SE df t.ratio p.value
1% Methanol - Media 0.0495857 0.0506121 8 0.9797199 0.355919
Table 1 Treatment = 0.07 J/cm2
contrast estimate SE df t.ratio p.value
1% Methanol - Media -0.0024703 0.0325128 8 -0.0759796 0.941301
Table 1 Treatment = 0.1 J/cm2
contrast estimate SE df t.ratio p.value
1% Methanol - Media -0.1123807 0.1222237 8 -0.9194672 0.3847366
Table 1 Treatment = 0.25 J/cm2
contrast estimate SE df t.ratio p.value
1% Methanol - Media -0.3694173 0.118795 8 -3.109703 0.014452
Table 1 Treatment = 0.5 J/cm2
contrast estimate SE df t.ratio p.value
1% Methanol - Media -0.1944595 0.0471408 7 -4.125082 0.0044312
Table 1 Treatment = 1 J/cm2
contrast estimate SE df t.ratio p.value
1% Methanol - Media -0.0487925 0.0264336 7 -1.845854 0.1074185

OVCAR-3 BPD-PDT Med VC

Table 2 Treatment = NT
contrast estimate SE df t.ratio p.value
1% Methanol - Media 0 0.0403243 8 0 1
Table 2 Treatment = BPD Only (0.25µM)
contrast estimate SE df t.ratio p.value
1% Methanol - Media -0.0070188 0.0320371 8 -0.2190822 0.8320721
Table 2 Treatment = Light Only (1 J/cm2)
contrast estimate SE df t.ratio p.value
1% Methanol - Media 0.043314 0.0453102 8 0.9559424 0.3670923
Table 2 Treatment = 0.03 J/cm2
contrast estimate SE df t.ratio p.value
1% Methanol - Media -0.0282246 0.0519228 8 -0.5435866 0.6015409
Table 2 Treatment = 0.05 J/cm2
contrast estimate SE df t.ratio p.value
1% Methanol - Media -0.0811775 0.037039 8 -2.191677 0.0597645
Table 2 Treatment = 0.07 J/cm2
contrast estimate SE df t.ratio p.value
1% Methanol - Media -0.0643182 0.032347 8 -1.988382 0.0819781
Table 2 Treatment = 0.1 J/cm2
contrast estimate SE df t.ratio p.value
1% Methanol - Media -0.0894683 0.052978 8 -1.688784 0.1297354
Table 2 Treatment = 0.25 J/cm2
contrast estimate SE df t.ratio p.value
1% Methanol - Media -0.3044683 0.0924804 8 -3.292249 0.0109851
Table 2 Treatment = 0.5 J/cm2
contrast estimate SE df t.ratio p.value
1% Methanol - Media -0.0732615 0.0129 8 -5.679194 0.0004654
Table 2 Treatment = 1 J/cm2
contrast estimate SE df t.ratio p.value
1% Methanol - Media -0.1079472 0.0425589 8 -2.536421 0.0349047

Caov-3 BPD-PDT + PFOA

Table 3 Env Factor = NT
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFOA 0.1127667 0.0448977 13 2.5116352 0.0513464
1% Methanol - 500nM PFOA -0.0059807 0.0448977 13 -0.1332081 0.9891983
Table 3 Env Factor = BPD Only (0.25µM)
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFOA 0.0994327 0.0274887 13 3.617225 0.0062445
1% Methanol - 500nM PFOA 0.0903186 0.0274887 13 3.285667 0.0117820
Table 3 Env Factor = Light Only (1 J/cm2)
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFOA 0.1165139 0.0463005 13 2.516472 0.0508859
1% Methanol - 500nM PFOA 0.1174240 0.0463005 13 2.536127 0.0490545
Table 3 Env Factor = 0.03 J/cm2
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFOA 0.0834033 0.0235675 13 3.538908 0.0072524
1% Methanol - 500nM PFOA 0.0662994 0.0235675 13 2.813171 0.0290962
Table 3 Env Factor = 0.05 J/cm2
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFOA 0.1165652 0.0346644 13 3.362675 0.0101641
1% Methanol - 500nM PFOA 0.0725755 0.0346644 13 2.093659 0.1097292
Table 3 Env Factor = 0.07 J/cm2
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFOA 0.0916271 0.0303522 13 3.0188002 0.0196531
1% Methanol - 500nM PFOA 0.0244611 0.0303522 13 0.8059096 0.6805374
Table 3 Env Factor = 0.1 J/cm2
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFOA 0.0567745 0.1352564 13 0.4197546 0.8985698
1% Methanol - 500nM PFOA 0.0154465 0.1352564 13 0.1142017 0.9920474
Table 3 Env Factor = 0.25 J/cm2
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFOA -0.0060917 0.1361455 13 -0.0447437 0.9987744
1% Methanol - 500nM PFOA -0.1399209 0.1361455 13 -1.0277308 0.5414273
Table 3 Env Factor = 0.5 J/cm2
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFOA -0.0086191 0.0116402 13 -0.7404580 0.7214111
1% Methanol - 500nM PFOA -0.0013279 0.0116402 13 -0.1140763 0.9920648
Table 3 Env Factor = 1 J/cm2
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFOA -0.0250107 0.022255 13 -1.1238192 0.4836346
1% Methanol - 500nM PFOA -0.0191902 0.022255 13 -0.8622873 0.6449698

OVCAR-3 BPD-PDT + PFOA

Table 4 Env Factor = NT
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFOA 0.0291711 0.0539363 13 0.5408431 0.8382041
1% Methanol - 500nM PFOA 0.0296411 0.0539363 13 0.5495575 0.8334862
Table 4 Env Factor = BPD Only (0.25µM)
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFOA -0.1026051 0.0461329 13 -2.2241210 0.0869817
1% Methanol - 500nM PFOA -0.0085944 0.0461329 13 -0.1862966 0.9790005
Table 4 Env Factor = Light Only (1 J/cm2)
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFOA 0.0513502 0.0711378 13 0.7218413 0.7328913
1% Methanol - 500nM PFOA 0.0417190 0.0711378 13 0.5864538 0.8130431
Table 4 Env Factor = 0.03 J/cm2
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFOA -0.0015209 0.0628669 13 -0.0241931 0.9996415
1% Methanol - 500nM PFOA -0.0005286 0.0628669 13 -0.0084088 0.9999567
Table 4 Env Factor = 0.05 J/cm2
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFOA -0.1027264 0.0788039 13 -1.3035697 0.3837651
1% Methanol - 500nM PFOA -0.0688788 0.0788039 13 -0.8740523 0.6375350
Table 4 Env Factor = 0.07 J/cm2
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFOA -0.0502307 0.0680737 13 -0.7378865 0.7230014
1% Methanol - 500nM PFOA 0.0913699 0.0680737 13 1.3422201 0.3639878
Table 4 Env Factor = 0.1 J/cm2
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFOA -0.0896230 0.1060814 13 -0.8448514 0.6559856
1% Methanol - 500nM PFOA 0.0311439 0.1060814 13 0.2935855 0.9487925
Table 4 Env Factor = 0.25 J/cm2
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFOA -0.0641821 0.0779581 13 -0.8232896 0.6695925
1% Methanol - 500nM PFOA -0.1129101 0.0779581 13 -1.4483439 0.3131040
Table 4 Env Factor = 0.5 J/cm2
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFOA -0.0232053 0.0338472 13 -0.6855885 0.7549903
1% Methanol - 500nM PFOA -0.0877155 0.0338472 13 -2.5915124 0.0442262
Table 4 Env Factor = 1 J/cm2
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFOA -0.0001372 0.0454073 13 -0.0030225 0.9999944
1% Methanol - 500nM PFOA -0.0971491 0.0454073 13 -2.1395029 0.1011859

[1] 5

Caov-3 BPD-PDT + PFHpA

Table 5 Env Factor = NT
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFHpA 0.0539296 0.0302736 13 1.781409 0.1867717
1% Methanol - 500nM PFHpA 0.0869796 0.0302736 13 2.873120 0.0259587
Table 5 Env Factor = BPD Only (0.25µM)
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFHpA 0.1039549 0.0313329 13 3.317757 0.0110785
1% Methanol - 500nM PFHpA 0.1033218 0.0313329 13 3.297552 0.0115164
Table 5 Env Factor = Light Only (1 J/cm2)
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFHpA 0.1203765 0.0334458 13 3.599149 0.0064638
1% Methanol - 500nM PFHpA 0.1350677 0.0334458 13 4.038402 0.0028114
Table 5 Env Factor = 0.03 J/cm2
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFHpA 0.1094596 0.0347605 13 3.148966 0.0153147
1% Methanol - 500nM PFHpA 0.0990278 0.0347605 13 2.848861 0.0271863
Table 5 Env Factor = 0.05 J/cm2
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFHpA 0.1005436 0.0445213 13 2.258328 0.0817763
1% Methanol - 500nM PFHpA 0.1024031 0.0445213 13 2.300094 0.0758102
Table 5 Env Factor = 0.07 J/cm2
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFHpA 0.1110031 0.0517387 13 2.145454 0.1001220
1% Methanol - 500nM PFHpA 0.0519362 0.0517387 13 1.003815 0.5561602
Table 5 Env Factor = 0.1 J/cm2
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFHpA 0.2307416 0.1194414 13 1.931839 0.1452462
1% Methanol - 500nM PFHpA 0.1318661 0.1194414 13 1.104024 0.4953309
Table 5 Env Factor = 0.25 J/cm2
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFHpA 0.0172283 0.0520696 13 0.3308708 0.9354913
1% Methanol - 500nM PFHpA 0.0452249 0.0520696 13 0.8685476 0.6410136
Table 5 Env Factor = 0.5 J/cm2
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFHpA -0.0040204 0.0102038 13 -0.394011 0.9099759
1% Methanol - 500nM PFHpA -0.0092519 0.0102038 13 -0.906709 0.6169134
Table 5 Env Factor = 1 J/cm2
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFHpA -0.0022774 0.0093337 13 -0.2439951 0.9642953
1% Methanol - 500nM PFHpA -0.0065411 0.0093337 13 -0.7007978 0.7457643

OVCAR-3 BPD-PDT + PFHpA

Table 6 Env Factor = NT
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFHpA 0.0595378 0.0433457 13 1.3735575 0.3484337
1% Methanol - 500nM PFHpA 0.0185219 0.0433457 13 0.4273058 0.8951206
Table 6 Env Factor = BPD Only (0.25µM)
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFHpA -0.0701214 0.0500359 13 -1.4014204 0.3349735
1% Methanol - 500nM PFHpA -0.0256378 0.0500359 13 -0.5123874 0.8532910
Table 6 Env Factor = Light Only (1 J/cm2)
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFHpA 0.0193358 0.0649118 13 0.2978786 0.9473312
1% Methanol - 500nM PFHpA 0.0706610 0.0649118 13 1.0885700 0.5045430
Table 6 Env Factor = 0.03 J/cm2
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFHpA -0.0047680 0.0474692 13 -0.1004431 0.9938417
1% Methanol - 500nM PFHpA 0.0449863 0.0474692 13 0.9476937 0.5911294
Table 6 Env Factor = 0.05 J/cm2
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFHpA -0.1095554 0.0538413 13 -2.0347832 0.1216459
1% Methanol - 500nM PFHpA -0.0434257 0.0538413 13 -0.8065493 0.6801350
Table 6 Env Factor = 0.07 J/cm2
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFHpA -0.0734369 0.0509821 13 -1.4404442 0.3167151
1% Methanol - 500nM PFHpA -0.0342922 0.0509821 13 -0.6726316 0.7627928
Table 6 Env Factor = 0.1 J/cm2
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFHpA 0.0383861 0.0828263 13 0.4634527 0.8779920
1% Methanol - 500nM PFHpA 0.1007965 0.0828263 13 1.2169615 0.4303539
Table 6 Env Factor = 0.25 J/cm2
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFHpA -0.3132029 0.1044159 13 -2.9995727 0.0203896
1% Methanol - 500nM PFHpA -0.0634032 0.1044159 13 -0.6072184 0.8012306
Table 6 Env Factor = 0.5 J/cm2
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFHpA -0.0104050 0.0090508 13 -1.149625 0.4685726
1% Methanol - 500nM PFHpA 0.0106726 0.0090508 13 1.179190 0.4515918
Table 6 Env Factor = 1 J/cm2
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFHpA 0.0011879 0.0023821 13 0.4986648 0.8603829
1% Methanol - 500nM PFHpA 0.0040804 0.0023821 13 1.7129522 0.2087058

Caov-3 BPD-PDT + PFPA

Table 7 Env Factor = NT
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFPA -0.0261039 0.0471835 13 -0.5532411 0.8314787
1% Methanol - 500nM PFPA 0.0195793 0.0471835 13 0.4149599 0.9007358
Table 7 Env Factor = BPD Only (0.25µM)
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFPA -0.0127522 0.0290098 13 -0.4395827 0.8894160
1% Methanol - 500nM PFPA 0.0226864 0.0290098 13 0.7820266 0.6955267
Table 7 Env Factor = Light Only (1 J/cm2)
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFPA -0.0084034 0.0471929 13 -0.1780658 0.9807945
1% Methanol - 500nM PFPA 0.0313083 0.0471929 13 0.6634103 0.7683114
Table 7 Env Factor = 0.03 J/cm2
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFPA 0.0171375 0.0331779 13 0.516534 0.8511240
1% Methanol - 500nM PFPA 0.0353299 0.0331779 13 1.064863 0.5188045
Table 7 Env Factor = 0.05 J/cm2
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFPA 0.0061593 0.0911272 13 0.0675897 0.9972059
1% Methanol - 500nM PFPA -0.0512921 0.0911272 13 -0.5628624 0.8261993
Table 7 Env Factor = 0.07 J/cm2
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFPA 0.0967627 0.082319 13 1.1754602 0.4537170
1% Methanol - 500nM PFPA 0.0645390 0.082319 13 0.7840111 0.6942839
Table 7 Env Factor = 0.1 J/cm2
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFPA 0.1609550 0.121219 13 1.3278032 0.3712891
1% Methanol - 500nM PFPA 0.0162241 0.121219 13 0.1338413 0.9890960
Table 7 Env Factor = 0.25 J/cm2
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFPA -0.1931465 0.0935642 13 -2.0643201 0.1155308
1% Methanol - 500nM PFPA -0.0780563 0.0935642 13 -0.8342537 0.6626765
Table 7 Env Factor = 0.5 J/cm2
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFPA -0.0134345 0.0170398 13 -0.7884187 0.6915218
1% Methanol - 500nM PFPA 0.0039558 0.0170398 13 0.2321480 0.9676135
Table 7 Env Factor = 1 J/cm2
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFPA -0.0288687 0.0159812 13 -1.8064154 0.1792484
1% Methanol - 500nM PFPA -0.0106976 0.0159812 13 -0.6693848 0.7647393

OVCAR-3 BPD-PDT + PFPA

Table 8 Env Factor = NT
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFPA 0.1018042 0.0579261 13 1.757482 0.1942125
1% Methanol - 500nM PFPA 0.1194635 0.0579261 13 2.062342 0.1159316
Table 8 Env Factor = BPD Only (0.25µM)
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFPA 0.0928932 0.0605695 13 1.533664 0.2759396
1% Methanol - 500nM PFPA 0.1081014 0.0605695 13 1.784750 0.1857516
Table 8 Env Factor = Light Only (1 J/cm2)
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFPA 0.1178452 0.0630353 13 1.869510 0.1613849
1% Methanol - 500nM PFPA 0.0888102 0.0630353 13 1.408895 0.3314225
Table 8 Env Factor = 0.03 J/cm2
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFPA 0.1445953 0.0727603 13 1.987282 0.1320815
1% Methanol - 500nM PFPA 0.1164989 0.0727603 13 1.601133 0.2489307
Table 8 Env Factor = 0.05 J/cm2
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFPA 0.0295725 0.076343 13 0.3873642 0.9128299
1% Methanol - 500nM PFPA 0.0375296 0.076343 13 0.4915920 0.8639892
Table 8 Env Factor = 0.07 J/cm2
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFPA 0.0666505 0.0660711 13 1.0087684 0.5530996
1% Methanol - 500nM PFPA 0.0438865 0.0660711 13 0.6642315 0.7678212
Table 8 Env Factor = 0.1 J/cm2
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFPA -0.0340966 0.0987062 13 -0.3454350 0.9299302
1% Methanol - 500nM PFPA 0.0150505 0.0987062 13 0.1524773 0.9858751
Table 8 Env Factor = 0.25 J/cm2
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFPA -0.1212787 0.0692344 13 -1.7517104 0.1960435
1% Methanol - 500nM PFPA -0.0628472 0.0692344 13 -0.9077443 0.6162605
Table 8 Env Factor = 0.5 J/cm2
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFPA 0.0008066 0.0133161 13 0.0605752 0.9977550
1% Methanol - 500nM PFPA -0.0050988 0.0133161 13 -0.3829068 0.9147223
Table 8 Env Factor = 1 J/cm2
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFPA 0.0042053 0.0049657 13 0.8468601 0.6547169
1% Methanol - 500nM PFPA -0.0024654 0.0049657 13 -0.4964822 0.8614993

Caov-3 BPD-PDT + Mix

Table 9 Env Factor = No Treatment
contrast estimate SE df t.ratio p.value
1% Methanol - (1µM PFHpA + 1µM PFPA) -0.0642959 0.0754894 23 -0.8517203 0.8731009
1% Methanol - (1µM PFOA + 1µM PFHpA) -0.0881325 0.0754894 23 -1.1674809 0.6919099
1% Methanol - (1µM PFOA + 1µM PFPA) -0.0609119 0.0754894 23 -0.8068925 0.8929461
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA) -0.0895812 0.0754894 23 -1.1866725 0.6793028
Table 9 Env Factor = BPD Only (0.25µM)
contrast estimate SE df t.ratio p.value
1% Methanol - (1µM PFHpA + 1µM PFPA) 0.0716723 0.0549945 23 1.3032651 0.6013088
1% Methanol - (1µM PFOA + 1µM PFHpA) -0.0086963 0.0549945 23 -0.1581299 0.9997615
1% Methanol - (1µM PFOA + 1µM PFPA) 0.0308630 0.0549945 23 0.5612024 0.9689088
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA) 0.0673226 0.0549945 23 1.2241699 0.6544216
Table 9 Env Factor = Light Only (1 J/cm2)
contrast estimate SE df t.ratio p.value
1% Methanol - (1µM PFHpA + 1µM PFPA) -0.0556935 0.0639269 23 -0.8712052 0.8639277
1% Methanol - (1µM PFOA + 1µM PFHpA) -0.0872878 0.0639269 23 -1.3654315 0.5595069
1% Methanol - (1µM PFOA + 1µM PFPA) -0.0514393 0.0639269 23 -0.8046574 0.8938886
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA) -0.0046950 0.0639269 23 -0.0734426 0.9999888
Table 9 Env Factor = 0.03 J/cm2
contrast estimate SE df t.ratio p.value
1% Methanol - (1µM PFHpA + 1µM PFPA) -0.0280821 0.0792102 23 -0.3545262 0.9943779
1% Methanol - (1µM PFOA + 1µM PFHpA) -0.0230407 0.0792102 23 -0.2908808 0.9973797
1% Methanol - (1µM PFOA + 1µM PFPA) -0.0763287 0.0792102 23 -0.9636214 0.8162282
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA) 0.0341414 0.0792102 23 0.4310228 0.9882074
Table 9 Env Factor = 0.05 J/cm2
contrast estimate SE df t.ratio p.value
1% Methanol - (1µM PFHpA + 1µM PFPA) 0.0892046 0.0928672 23 0.9605612 0.8179113
1% Methanol - (1µM PFOA + 1µM PFHpA) 0.0055238 0.0928672 23 0.0594812 0.9999952
1% Methanol - (1µM PFOA + 1µM PFPA) 0.0012967 0.0928672 23 0.0139626 1.0000000
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA) 0.1854728 0.0928672 23 1.9971834 0.2118156
Table 9 Env Factor = 0.07 J/cm2
contrast estimate SE df t.ratio p.value
1% Methanol - (1µM PFHpA + 1µM PFPA) 0.2359161 0.1022568 23 2.307095 0.1161516
1% Methanol - (1µM PFOA + 1µM PFHpA) 0.0390865 0.1022568 23 0.382239 0.9925078
1% Methanol - (1µM PFOA + 1µM PFPA) 0.1414062 0.1022568 23 1.382854 0.5478543
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA) 0.3228120 0.1022568 23 3.156877 0.0175225
Table 9 Env Factor = 0.1 J/cm2
contrast estimate SE df t.ratio p.value
1% Methanol - (1µM PFHpA + 1µM PFPA) 0.4653259 0.1297645 23 3.585927 0.0062373
1% Methanol - (1µM PFOA + 1µM PFHpA) 0.4318824 0.1297645 23 3.328203 0.0116470
1% Methanol - (1µM PFOA + 1µM PFPA) 0.5142685 0.1297645 23 3.963092 0.0024638
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA) 0.5338987 0.1297645 23 4.114368 0.0016922
Table 9 Env Factor = 0.25 J/cm2
contrast estimate SE df t.ratio p.value
1% Methanol - (1µM PFHpA + 1µM PFPA) 0.2136018 0.0237664 23 8.987567 0e+00
1% Methanol - (1µM PFOA + 1µM PFHpA) 0.1978639 0.0237664 23 8.325373 1e-07
1% Methanol - (1µM PFOA + 1µM PFPA) 0.2104446 0.0237664 23 8.854724 0e+00
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA) 0.2193944 0.0237664 23 9.231298 0e+00
Table 9 Env Factor = 0.5 J/cm2
contrast estimate SE df t.ratio p.value
1% Methanol - (1µM PFHpA + 1µM PFPA) 0.0709634 0.0106261 23 6.678197 3.3e-06
1% Methanol - (1µM PFOA + 1µM PFHpA) 0.0683286 0.0106261 23 6.430246 5.8e-06
1% Methanol - (1µM PFOA + 1µM PFPA) 0.0704303 0.0106261 23 6.628031 3.7e-06
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA) 0.0735039 0.0106261 23 6.917278 1.9e-06
Table 9 Env Factor = 1 J/cm2
contrast estimate SE df t.ratio p.value
1% Methanol - (1µM PFHpA + 1µM PFPA) 0.0322277 0.004648 23 6.933682 1.8e-06
1% Methanol - (1µM PFOA + 1µM PFHpA) 0.0311418 0.004648 23 6.700042 3.1e-06
1% Methanol - (1µM PFOA + 1µM PFPA) 0.0312988 0.004648 23 6.733819 2.9e-06
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA) 0.0374865 0.004648 23 8.065079 1.0e-07

OVCAR-3 BPD-PDT + Mix

Table 10 Env Factor = No Treatment
contrast estimate SE df t.ratio p.value
1% Methanol - (1µM PFHpA + 1µM PFPA) -0.1179821 0.0668679 23 -1.7644060 0.3170862
1% Methanol - (1µM PFOA + 1µM PFHpA) -0.1291844 0.0668679 23 -1.9319346 0.2382721
1% Methanol - (1µM PFOA + 1µM PFPA) -0.1332205 0.0668679 23 -1.9922944 0.2137167
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA) 0.0254508 0.0668679 23 0.3806127 0.9926283
Table 10 Env Factor = BPD Only (0.25µM)
contrast estimate SE df t.ratio p.value
1% Methanol - (1µM PFHpA + 1µM PFPA) -0.1239091 0.063266 23 -1.9585432 0.2271989
1% Methanol - (1µM PFOA + 1µM PFHpA) -0.0197809 0.063266 23 -0.3126624 0.9965335
1% Methanol - (1µM PFOA + 1µM PFPA) -0.1705348 0.063266 23 -2.6955224 0.0506463
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA) -0.0438181 0.063266 23 -0.6926010 0.9352165
Table 10 Env Factor = Light Only (1 J/cm2)
contrast estimate SE df t.ratio p.value
1% Methanol - (1µM PFHpA + 1µM PFPA) -0.1466851 0.0858994 23 -1.707638 0.3473017
1% Methanol - (1µM PFOA + 1µM PFHpA) -0.1632728 0.0858994 23 -1.900743 0.2517555
1% Methanol - (1µM PFOA + 1µM PFPA) -0.1179597 0.0858994 23 -1.373230 0.5542862
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA) -0.0430325 0.0858994 23 -0.500964 0.9794015
Table 10 Env Factor = 0.03 J/cm2
contrast estimate SE df t.ratio p.value
1% Methanol - (1µM PFHpA + 1µM PFPA) -0.1216791 0.0744048 23 -1.6353668 0.3881808
1% Methanol - (1µM PFOA + 1µM PFHpA) -0.0718824 0.0744048 23 -0.9660992 0.8148605
1% Methanol - (1µM PFOA + 1µM PFPA) -0.0377485 0.0744048 23 -0.5073392 0.9784255
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA) -0.0309943 0.0744048 23 -0.4165638 0.9896264
Table 10 Env Factor = 0.05 J/cm2
contrast estimate SE df t.ratio p.value
1% Methanol - (1µM PFHpA + 1µM PFPA) -0.0848946 0.1346308 23 -0.6305731 0.9530597
1% Methanol - (1µM PFOA + 1µM PFHpA) -0.0538758 0.1346308 23 -0.4001740 0.9910848
1% Methanol - (1µM PFOA + 1µM PFPA) -0.0574933 0.1346308 23 -0.4270442 0.9886106
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA) -0.0883055 0.1346308 23 -0.6559082 0.9462007
Table 10 Env Factor = 0.07 J/cm2
contrast estimate SE df t.ratio p.value
1% Methanol - (1µM PFHpA + 1µM PFPA) 0.1484958 0.1112916 23 1.334294 0.5804149
1% Methanol - (1µM PFOA + 1µM PFHpA) 0.1971829 0.1112916 23 1.771767 0.3132953
1% Methanol - (1µM PFOA + 1µM PFPA) 0.2006168 0.1112916 23 1.802623 0.2977292
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA) 0.1231068 0.1112916 23 1.106164 0.7313986
Table 10 Env Factor = 0.1 J/cm2
contrast estimate SE df t.ratio p.value
1% Methanol - (1µM PFHpA + 1µM PFPA) 0.4685486 0.0965048 23 4.855182 0.0002673
1% Methanol - (1µM PFOA + 1µM PFHpA) 0.4226822 0.0965048 23 4.379907 0.0008733
1% Methanol - (1µM PFOA + 1µM PFPA) 0.4828945 0.0965048 23 5.003837 0.0001848
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA) 0.3532236 0.0965048 23 3.660164 0.0052012
Table 10 Env Factor = 0.25 J/cm2
contrast estimate SE df t.ratio p.value
1% Methanol - (1µM PFHpA + 1µM PFPA) 0.1161599 0.0362166 23 3.207365 0.0155456
1% Methanol - (1µM PFOA + 1µM PFHpA) 0.0964106 0.0362166 23 2.662056 0.0545474
1% Methanol - (1µM PFOA + 1µM PFPA) 0.1150119 0.0362166 23 3.175669 0.0167600
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA) 0.1192349 0.0362166 23 3.292273 0.0126950
Table 10 Env Factor = 0.5 J/cm2
contrast estimate SE df t.ratio p.value
1% Methanol - (1µM PFHpA + 1µM PFPA) -0.0284982 0.020358 23 -1.3998508 0.5365308
1% Methanol - (1µM PFOA + 1µM PFHpA) -0.0070311 0.020358 23 -0.3453736 0.9949142
1% Methanol - (1µM PFOA + 1µM PFPA) -0.0120757 0.020358 23 -0.5931675 0.9621282
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA) -0.0181642 0.020358 23 -0.8922397 0.8536659
Table 10 Env Factor = 1 J/cm2
contrast estimate SE df t.ratio p.value
1% Methanol - (1µM PFHpA + 1µM PFPA) 0.0009792 0.007311 23 0.133932 0.9998767
1% Methanol - (1µM PFOA + 1µM PFHpA) 0.0084477 0.007311 23 1.155480 0.6997402
1% Methanol - (1µM PFOA + 1µM PFPA) 0.0074407 0.007311 23 1.017736 0.7854182
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA) -0.0098389 0.007311 23 -1.345770 0.5726994

Caov-3 ALA-PDT Med VC

Table 11 Treatment = 0
contrast estimate SE df t.ratio p.value
1% Methanol - Media -0.0641104 0.0395612 20 -1.620535 0.1207781
Table 11 Treatment = ALA Only
contrast estimate SE df t.ratio p.value
1% Methanol - Media -0.0106708 0.0336712 20 -0.3169105 0.7545958
Table 11 Treatment = Light Only (25 J)
contrast estimate SE df t.ratio p.value
1% Methanol - Media -0.0369194 0.0452653 20 -0.815622 0.4243239
Table 11 Treatment = 1
contrast estimate SE df t.ratio p.value
1% Methanol - Media 0.001671 0.0414482 20 0.0403154 0.9682414
Table 11 Treatment = 2.5
contrast estimate SE df t.ratio p.value
1% Methanol - Media -0.0385495 0.03504 20 -1.100157 0.28433
Table 11 Treatment = 5
contrast estimate SE df t.ratio p.value
1% Methanol - Media 0.1784037 0.0649824 20 2.745418 0.0124714
Table 11 Treatment = 10
contrast estimate SE df t.ratio p.value
1% Methanol - Media 0.2134322 0.027446 20 7.776428 2e-07
Table 11 Treatment = 15
contrast estimate SE df t.ratio p.value
1% Methanol - Media 0.0913599 0.0118994 20 7.677687 2e-07
Table 11 Treatment = 20
contrast estimate SE df t.ratio p.value
1% Methanol - Media 0.0243709 0.0132038 20 1.845747 0.0797858
Table 11 Treatment = 25
contrast estimate SE df t.ratio p.value
1% Methanol - Media 0.0308548 0.0075341 20 4.09533 0.0005629

Caov-3 ALA-PDT + PFOA

Table 12 Env Factor = 0
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFOA 0.0979773 0.0404451 13 2.4224746 0.0605778
1% Methanol - 500nM PFOA 0.0260768 0.0404451 13 0.6447455 0.7793873
Table 12 Env Factor = ALA Only
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFOA 0.0369797 0.02945 13 1.2556771 0.4091517
1% Methanol - 500nM PFOA 0.0178052 0.02945 13 0.6045888 0.8027379
Table 12 Env Factor = Light Only (25 J)
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFOA -0.0526236 0.0280575 13 -1.8755627 0.1597533
1% Methanol - 500nM PFOA 0.0114088 0.0280575 13 0.4066219 0.9044576
Table 12 Env Factor = 1
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFOA 0.0106565 0.0310093 13 0.3436542 0.9306209
1% Methanol - 500nM PFOA 0.0314590 0.0310093 13 1.0145015 0.5495628
Table 12 Env Factor = 2.5
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFOA -0.0640133 0.0477964 13 -1.3392926 0.3654630
1% Methanol - 500nM PFOA 0.0144442 0.0477964 13 0.3022025 0.9458406
Table 12 Env Factor = 5
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFOA -0.1328043 0.0960601 13 -1.3825129 0.3440693
1% Methanol - 500nM PFOA 0.0293194 0.0960601 13 0.3052191 0.9447897
Table 12 Env Factor = 10
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFOA -0.0986017 0.1251792 13 -0.7876847 0.6919820
1% Methanol - 500nM PFOA -0.0026514 0.1251792 13 -0.0211810 0.9997252
Table 12 Env Factor = 15
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFOA -0.1303623 0.0787896 13 -1.6545622 0.2290149
1% Methanol - 500nM PFOA -0.0393373 0.0787896 13 -0.4992697 0.8600729
Table 12 Env Factor = 20
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFOA -0.0807143 0.0431146 13 -1.8720870 0.1606885
1% Methanol - 500nM PFOA -0.0074557 0.0431146 13 -0.1729279 0.9818752
Table 12 Env Factor = 25
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFOA -0.0527912 0.0323322 13 -1.6327737 0.2369811
1% Methanol - 500nM PFOA 0.0060557 0.0323322 13 0.1872969 0.9787772

Caov-3 ALA-PDT + PFHpA

Table 13 Env Factor = 0
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFHpA -0.0219197 0.0348379 13 -0.6291906 0.7885140
1% Methanol - 500nM PFHpA -0.0323294 0.0348379 13 -0.9279949 0.6035034
Table 13 Env Factor = ALA Only
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFHpA -0.0291813 0.0458313 13 -0.6367102 0.7841143
1% Methanol - 500nM PFHpA -0.0080990 0.0458313 13 -0.1767131 0.9810819
Table 13 Env Factor = Light Only (25 J)
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFHpA -0.1328881 0.0492593 13 -2.697729 0.0362119
1% Methanol - 500nM PFHpA -0.1099927 0.0492593 13 -2.232934 0.0856122
Table 13 Env Factor = 1
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFHpA -0.0565544 0.0387514 13 -1.4594159 0.3080912
1% Methanol - 500nM PFHpA -0.0201769 0.0387514 13 -0.5206756 0.8489486
Table 13 Env Factor = 2.5
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFHpA -0.0978517 0.0523049 13 -1.870793 0.1610378
1% Methanol - 500nM PFHpA -0.0945986 0.0523049 13 -1.808599 0.1786036
Table 13 Env Factor = 5
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFHpA -0.1672113 0.0951493 13 -1.757357 0.1942520
1% Methanol - 500nM PFHpA -0.2089265 0.0951493 13 -2.195776 0.0915233
Table 13 Env Factor = 10
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFHpA -0.0206800 0.0952268 13 -0.2171657 0.9715910
1% Methanol - 500nM PFHpA 0.0183768 0.0952268 13 0.1929788 0.9774873
Table 13 Env Factor = 15
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFHpA -0.0107942 0.0552732 13 -0.1952879 0.9769527
1% Methanol - 500nM PFHpA -0.0100726 0.0552732 13 -0.1822337 0.9798957
Table 13 Env Factor = 20
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFHpA -0.0395873 0.0311376 13 -1.271365 0.4007314
1% Methanol - 500nM PFHpA -0.0130527 0.0311376 13 -0.419195 0.8988235
Table 13 Env Factor = 25
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFHpA -0.0248074 0.0293453 13 -0.8453624 0.6556629
1% Methanol - 500nM PFHpA -0.0117555 0.0293453 13 -0.4005925 0.9071127

Caov-3 ALA-PDT + PFPA

Table 14 Env Factor = 0
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFPA -0.0415571 0.0345475 13 -1.202898 0.4381994
1% Methanol - 500nM PFPA 0.0348138 0.0345475 13 1.007710 0.5537534
Table 14 Env Factor = ALA Only
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFPA -0.0395402 0.0359452 13 -1.1000143 0.4977144
1% Methanol - 500nM PFPA 0.0301650 0.0359452 13 0.8391949 0.6595575
Table 14 Env Factor = Light Only (25 J)
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFPA -0.0864005 0.0728492 13 -1.1860187 0.4477131
1% Methanol - 500nM PFPA -0.0577854 0.0728492 13 -0.7932195 0.6885104
Table 14 Env Factor = 1
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFPA 0.0185019 0.0330431 13 0.5599316 0.8278130
1% Methanol - 500nM PFPA 0.0393760 0.0330431 13 1.1916558 0.4445242
Table 14 Env Factor = 2.5
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFPA -0.0547831 0.0339405 13 -1.6140915 0.2439819
1% Methanol - 500nM PFPA -0.0222413 0.0339405 13 -0.6553015 0.7731393
Table 14 Env Factor = 5
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFPA -0.1411664 0.0778089 13 -1.8142707 0.1769378
1% Methanol - 500nM PFPA 0.0054860 0.0778089 13 0.0705058 0.9969600
Table 14 Env Factor = 10
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFPA -0.0842117 0.1148763 13 -0.7330638 0.7259803
1% Methanol - 500nM PFPA 0.0028150 0.1148763 13 0.0245048 0.9996322
Table 14 Env Factor = 15
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFPA -0.0997628 0.0698142 13 -1.4289758 0.3220086
1% Methanol - 500nM PFPA -0.0511462 0.0698142 13 -0.7326044 0.7262638
Table 14 Env Factor = 20
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFPA -0.0667634 0.0384819 13 -1.7349303 0.2014466
1% Methanol - 500nM PFPA -0.0298382 0.0384819 13 -0.7753824 0.6996835
Table 14 Env Factor = 25
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFPA -0.0392896 0.0324043 13 -1.2124816 0.4328449
1% Methanol - 500nM PFPA -0.0276270 0.0324043 13 -0.8525738 0.6511075

OVCAR-3 ALA-PDT Med VC

Table 15 Treatment = 0
contrast estimate SE df t.ratio p.value
1% Methanol - Media -0.0422626 0.0395015 26 -1.069897 0.294498
Table 15 Treatment = ALA Only
contrast estimate SE df t.ratio p.value
1% Methanol - Media 0.0624483 0.0343095 26 1.820147 0.0802683
Table 15 Treatment = Light Only (25 J)
contrast estimate SE df t.ratio p.value
1% Methanol - Media 0.0719961 0.0432999 26 1.662732 0.1083765
Table 15 Treatment = 1
contrast estimate SE df t.ratio p.value
1% Methanol - Media 0.1280113 0.0373705 26 3.425464 0.0020488
Table 15 Treatment = 2.5
contrast estimate SE df t.ratio p.value
1% Methanol - Media 0.1948819 0.0346624 26 5.622285 6.6e-06
Table 15 Treatment = 5
contrast estimate SE df t.ratio p.value
1% Methanol - Media 0.2529004 0.0395266 26 6.398237 9e-07
Table 15 Treatment = 10
contrast estimate SE df t.ratio p.value
1% Methanol - Media 0.4878706 0.0442636 26 11.02193 0
Table 15 Treatment = 15
contrast estimate SE df t.ratio p.value
1% Methanol - Media 0.6147282 0.0483638 26 12.71049 0
Table 15 Treatment = 20
contrast estimate SE df t.ratio p.value
1% Methanol - Media 0.4853157 0.0440885 26 11.00776 0
Table 15 Treatment = 25
contrast estimate SE df t.ratio p.value
1% Methanol - Media 0.2890271 0.0319588 26 9.043741 0

OVCAR-3 ALA-PDT + PFOA

Table 16 Env Factor = 0
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFOA -0.0040792 0.0655894 19 -0.0621932 0.9976047
1% Methanol - 500nM PFOA -0.1301036 0.0655894 19 -1.9836072 0.1200433
Table 16 Env Factor = ALA Only
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFOA -0.0417645 0.0593285 19 -0.7039538 0.739900
1% Methanol - 500nM PFOA -0.0508804 0.0593285 19 -0.8576050 0.642156
Table 16 Env Factor = Light Only (25 J)
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFOA 0.0584860 0.0718819 19 0.8136399 0.6704446
1% Methanol - 500nM PFOA 0.1090151 0.0718819 19 1.5165869 0.2703988
Table 16 Env Factor = 1
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFOA -0.0239739 0.0807501 19 -0.2968895 0.9469951
1% Methanol - 500nM PFOA 0.0534113 0.0807501 19 0.6614386 0.7660081
Table 16 Env Factor = 2.5
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFOA -0.0123641 0.0527918 19 -0.2342058 0.9666318
1% Methanol - 500nM PFOA 0.0463424 0.0527918 19 0.8778337 0.6291185
Table 16 Env Factor = 5
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFOA -0.0553198 0.0656328 19 -0.8428690 0.6516490
1% Methanol - 500nM PFOA 0.0172430 0.0656328 19 0.2627199 0.9582182
Table 16 Env Factor = 10
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFOA -0.0791463 0.0728333 19 -1.0866779 0.4969980
1% Methanol - 500nM PFOA -0.0072084 0.0728333 19 -0.0989717 0.9939468
Table 16 Env Factor = 15
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFOA -0.0111560 0.0906035 19 -0.1231302 0.9906486
1% Methanol - 500nM PFOA 0.0196042 0.0906035 19 0.2163740 0.9714398
Table 16 Env Factor = 20
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFOA -0.1297296 0.0878303 19 -1.4770479 0.2877429
1% Methanol - 500nM PFOA -0.0671399 0.0878303 19 -0.7644279 0.7018863
Table 16 Env Factor = 25
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFOA -0.1435940 0.0621791 19 -2.309364 0.0636067
1% Methanol - 500nM PFOA -0.0858571 0.0621791 19 -1.380804 0.3331106

OVCAR-3 ALA-PDT + PFHpA

Table 17 Env Factor = 0
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFHpA -0.1153406 0.0440429 19 -2.618825 0.0334989
1% Methanol - 500nM PFHpA -0.0486581 0.0440429 19 -1.104791 0.4859757
Table 17 Env Factor = ALA Only
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFHpA -0.1381871 0.0558304 19 -2.475121 0.0452934
1% Methanol - 500nM PFHpA -0.0616230 0.0558304 19 -1.103754 0.4866040
Table 17 Env Factor = Light Only (25 J)
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFHpA 0.0139617 0.0738207 19 0.1891293 0.9780952
1% Methanol - 500nM PFHpA 0.1266142 0.0738207 19 1.7151588 0.1946374
Table 17 Env Factor = 1
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFHpA -0.0586972 0.0619575 19 -0.9473780 0.5844144
1% Methanol - 500nM PFHpA -0.0500266 0.0619575 19 -0.8074345 0.6744262
Table 17 Env Factor = 2.5
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFHpA -0.0652192 0.0547043 19 -1.1922148 0.4342782
1% Methanol - 500nM PFHpA -0.0227462 0.0547043 19 -0.4158036 0.8990110
Table 17 Env Factor = 5
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFHpA -0.0826768 0.0649496 19 -1.272938 0.3890953
1% Methanol - 500nM PFHpA -0.0656427 0.0649496 19 -1.010671 0.5442027
Table 17 Env Factor = 10
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFHpA -0.1193492 0.0682011 19 -1.7499614 0.1832508
1% Methanol - 500nM PFHpA -0.0607702 0.0682011 19 -0.8910443 0.6206061
Table 17 Env Factor = 15
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFHpA -0.1339999 0.0825458 19 -1.6233410 0.2273442
1% Methanol - 500nM PFHpA -0.0328832 0.0825458 19 -0.3983632 0.9068551
Table 17 Env Factor = 20
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFHpA -0.1883183 0.0771153 19 -2.442033 0.0485067
1% Methanol - 500nM PFHpA -0.0910761 0.0771153 19 -1.181038 0.4407371
Table 17 Env Factor = 25
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFHpA -0.1636843 0.0600345 19 -2.726503 0.026620
1% Methanol - 500nM PFHpA -0.1219468 0.0600345 19 -2.031278 0.109722

OVCAR-3 ALA-PDT + PFPA

Table 18 Env Factor = 0
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFPA -0.0689919 0.052353 19 -1.317821 0.3651623
1% Methanol - 500nM PFPA -0.0885568 0.052353 19 -1.691531 0.2026807
Table 18 Env Factor = ALA Only
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFPA -0.0748578 0.0703964 19 -1.063375 0.5113162
1% Methanol - 500nM PFPA -0.1562762 0.0703964 19 -2.219945 0.0760693
Table 18 Env Factor = Light Only (25 J)
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFPA -0.1135310 0.0769412 19 -1.475555 0.2884125
1% Methanol - 500nM PFPA -0.1043904 0.0769412 19 -1.356755 0.3451328
Table 18 Env Factor = 1
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFPA -0.1565984 0.0716511 19 -2.185569 0.0814153
1% Methanol - 500nM PFPA -0.2978128 0.0716511 19 -4.156431 0.0010718
Table 18 Env Factor = 2.5
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFPA -0.2212689 0.0771949 19 -2.866366 0.0196658
1% Methanol - 500nM PFPA -0.1286173 0.0771949 19 -1.666137 0.2116114
Table 18 Env Factor = 5
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFPA -0.2103315 0.0717169 19 -2.932804 0.0170062
1% Methanol - 500nM PFPA -0.1456910 0.0717169 19 -2.031475 0.1096809
Table 18 Env Factor = 10
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFPA -0.1271980 0.0854186 19 -1.489114 0.2823698
1% Methanol - 500nM PFPA -0.1467171 0.0854186 19 -1.717625 0.1938126
Table 18 Env Factor = 15
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFPA -0.1372437 0.0883128 19 -1.554064 0.2546585
1% Methanol - 500nM PFPA -0.2889688 0.0883128 19 -3.272106 0.0080027
Table 18 Env Factor = 20
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFPA -0.1531234 0.0798657 19 -1.917263 0.1357800
1% Methanol - 500nM PFPA -0.1638526 0.0798657 19 -2.051603 0.1055596
Table 18 Env Factor = 25
contrast estimate SE df t.ratio p.value
1% Methanol - 2µM PFPA -0.1566736 0.052989 19 -2.956717 0.0161362
1% Methanol - 500nM PFPA -0.2020002 0.052989 19 -3.812112 0.0023522

Caov-3 ALA-PDT + PFAS Mixtures

Table 19 Env Factor = 0
contrast estimate SE df t.ratio p.value
1% Methanol - (1µM PFHpA + 1µM PFPA) -0.0352918 0.0417159 23 -0.8460036 0.8757303
1% Methanol - (1µM PFOA + 1µM PFHpA) -0.0199325 0.0417159 23 -0.4778154 0.9826926
1% Methanol - (1µM PFOA + 1µM PFPA) -0.0614907 0.0417159 23 -1.4740342 0.4878206
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA) -0.0118820 0.0417159 23 -0.2848321 0.9975851
Table 19 Env Factor = ALA Only
contrast estimate SE df t.ratio p.value
1% Methanol - (1µM PFHpA + 1µM PFPA) -0.0238273 0.035722 23 -0.6670217 0.9430058
1% Methanol - (1µM PFOA + 1µM PFHpA) 0.0135902 0.035722 23 0.3804432 0.9926408
1% Methanol - (1µM PFOA + 1µM PFPA) -0.0616044 0.035722 23 -1.7245515 0.3381197
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA) -0.0205503 0.035722 23 -0.5752851 0.9660291
Table 19 Env Factor = Light Only (25 J)
contrast estimate SE df t.ratio p.value
1% Methanol - (1µM PFHpA + 1µM PFPA) -0.1645832 0.0734827 23 -2.2397551 0.1330576
1% Methanol - (1µM PFOA + 1µM PFHpA) -0.0480637 0.0734827 23 -0.6540821 0.9467147
1% Methanol - (1µM PFOA + 1µM PFPA) -0.1131890 0.0734827 23 -1.5403497 0.4456319
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA) -0.0907168 0.0734827 23 -1.2345334 0.6474990
Table 19 Env Factor = 1
contrast estimate SE df t.ratio p.value
1% Methanol - (1µM PFHpA + 1µM PFPA) -0.0429626 0.0512309 23 -0.8386067 0.8790902
1% Methanol - (1µM PFOA + 1µM PFHpA) -0.0247156 0.0512309 23 -0.4824361 0.9820667
1% Methanol - (1µM PFOA + 1µM PFPA) -0.0895102 0.0512309 23 -1.7471919 0.3260662
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA) -0.0425895 0.0512309 23 -0.8313248 0.8823508
Table 19 Env Factor = 2.5
contrast estimate SE df t.ratio p.value
1% Methanol - (1µM PFHpA + 1µM PFPA) -0.1400589 0.0580313 23 -2.413504 0.0932139
1% Methanol - (1µM PFOA + 1µM PFHpA) -0.1245709 0.0580313 23 -2.146615 0.1598249
1% Methanol - (1µM PFOA + 1µM PFPA) -0.2014131 0.0580313 23 -3.470764 0.0082557
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA) -0.1485551 0.0580313 23 -2.559911 0.0682163
Table 19 Env Factor = 5
contrast estimate SE df t.ratio p.value
1% Methanol - (1µM PFHpA + 1µM PFPA) -0.2746824 0.0690895 23 -3.975747 0.0023877
1% Methanol - (1µM PFOA + 1µM PFHpA) -0.3107729 0.0690895 23 -4.498119 0.0006504
1% Methanol - (1µM PFOA + 1µM PFPA) -0.3246183 0.0690895 23 -4.698518 0.0003947
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA) -0.2557185 0.0690895 23 -3.701263 0.0047022
Table 19 Env Factor = 10
contrast estimate SE df t.ratio p.value
1% Methanol - (1µM PFHpA + 1µM PFPA) -0.5355286 0.1161747 23 -4.609684 0.0004924
1% Methanol - (1µM PFOA + 1µM PFHpA) -0.5131446 0.1161747 23 -4.417009 0.0007962
1% Methanol - (1µM PFOA + 1µM PFPA) -0.5794142 0.1161747 23 -4.987440 0.0001925
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA) -0.5437478 0.1161747 23 -4.680433 0.0004129
Table 19 Env Factor = 15
contrast estimate SE df t.ratio p.value
1% Methanol - (1µM PFHpA + 1µM PFPA) -0.6294183 0.1322066 23 -4.760869 0.0003379
1% Methanol - (1µM PFOA + 1µM PFHpA) -0.6375104 0.1322066 23 -4.822077 0.0002902
1% Methanol - (1µM PFOA + 1µM PFPA) -0.6958974 0.1322066 23 -5.263712 0.0000972
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA) -0.6288169 0.1322066 23 -4.756320 0.0003418
Table 19 Env Factor = 20
contrast estimate SE df t.ratio p.value
1% Methanol - (1µM PFHpA + 1µM PFPA) -0.6058996 0.1232077 23 -4.917710 0.0002288
1% Methanol - (1µM PFOA + 1µM PFHpA) -0.5815343 0.1232077 23 -4.719953 0.0003742
1% Methanol - (1µM PFOA + 1µM PFPA) -0.6631489 0.1232077 23 -5.382367 0.0000726
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA) -0.6410722 0.1232077 23 -5.203184 0.0001129
Table 19 Env Factor = 25
contrast estimate SE df t.ratio p.value
1% Methanol - (1µM PFHpA + 1µM PFPA) -0.5207697 0.1025368 23 -5.078858 0.0001535
1% Methanol - (1µM PFOA + 1µM PFHpA) -0.4594157 0.1025368 23 -4.480497 0.0006796
1% Methanol - (1µM PFOA + 1µM PFPA) -0.5453682 0.1025368 23 -5.318758 0.0000849
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA) -0.5548226 0.1025368 23 -5.410962 0.0000677

OVCAR-3 ALA-PDT + PFAS Mixtures

Table 20 Env Factor = 0
contrast estimate SE df t.ratio p.value
1% Methanol - (1µM PFHpA + 1µM PFPA) -0.1524139 0.0706827 35 -2.1563101 0.1435993
1% Methanol - (1µM PFOA + 1µM PFHpA) -0.1332222 0.0706827 35 -1.8847919 0.2447904
1% Methanol - (1µM PFOA + 1µM PFPA) -0.0648846 0.0706827 35 -0.9179693 0.8373254
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA) 0.0185488 0.0706827 35 0.2624238 0.9982178
Table 20 Env Factor = ALA Only
contrast estimate SE df t.ratio p.value
1% Methanol - (1µM PFHpA + 1µM PFPA) -0.1204027 0.067565 35 -1.7820288 0.2942084
1% Methanol - (1µM PFOA + 1µM PFHpA) -0.1291838 0.067565 35 -1.9119942 0.2327530
1% Methanol - (1µM PFOA + 1µM PFPA) -0.0842675 0.067565 35 -1.2472065 0.6309932
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA) -0.0506937 0.067565 35 -0.7502955 0.9137608
Table 20 Env Factor = Light Only (25 J)
contrast estimate SE df t.ratio p.value
1% Methanol - (1µM PFHpA + 1µM PFPA) -0.0959286 0.0662771 35 -1.4473853 0.4942286
1% Methanol - (1µM PFOA + 1µM PFHpA) -0.0362737 0.0662771 35 -0.5473033 0.9710871
1% Methanol - (1µM PFOA + 1µM PFPA) -0.0840858 0.0662771 35 -1.2686992 0.6162293
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA) 0.0221160 0.0662771 35 0.3336902 0.9954726
Table 20 Env Factor = 1
contrast estimate SE df t.ratio p.value
1% Methanol - (1µM PFHpA + 1µM PFPA) -0.1190116 0.0648019 35 -1.836545 0.2672165
1% Methanol - (1µM PFOA + 1µM PFHpA) -0.1559643 0.0648019 35 -2.406785 0.0832887
1% Methanol - (1µM PFOA + 1µM PFPA) -0.1082359 0.0648019 35 -1.670258 0.3548793
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA) -0.1036542 0.0648019 35 -1.599556 0.3967166
Table 20 Env Factor = 2.5
contrast estimate SE df t.ratio p.value
1% Methanol - (1µM PFHpA + 1µM PFPA) -0.1942611 0.0602889 35 -3.2221727 0.0109565
1% Methanol - (1µM PFOA + 1µM PFHpA) -0.0968710 0.0602889 35 -1.6067820 0.3923269
1% Methanol - (1µM PFOA + 1µM PFPA) -0.0847490 0.0602889 35 -1.4057161 0.5222619
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA) -0.0314653 0.0602889 35 -0.5219084 0.9756615
Table 20 Env Factor = 5
contrast estimate SE df t.ratio p.value
1% Methanol - (1µM PFHpA + 1µM PFPA) -0.1759057 0.0626425 35 -2.808087 0.0319906
1% Methanol - (1µM PFOA + 1µM PFHpA) -0.1200072 0.0626425 35 -1.915747 0.2311265
1% Methanol - (1µM PFOA + 1µM PFPA) -0.0857097 0.0626425 35 -1.368236 0.5477865
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA) -0.0345143 0.0626425 35 -0.550972 0.9703823
Table 20 Env Factor = 10
contrast estimate SE df t.ratio p.value
1% Methanol - (1µM PFHpA + 1µM PFPA) -0.2283646 0.070908 35 -3.220578 0.0110033
1% Methanol - (1µM PFOA + 1µM PFHpA) -0.1260750 0.070908 35 -1.778009 0.2962675
1% Methanol - (1µM PFOA + 1µM PFPA) -0.1791792 0.070908 35 -2.526926 0.0631645
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA) -0.1009560 0.070908 35 -1.423761 0.5100708
Table 20 Env Factor = 15
contrast estimate SE df t.ratio p.value
1% Methanol - (1µM PFHpA + 1µM PFPA) -0.0726390 0.0732649 35 -0.9914568 0.7963968
1% Methanol - (1µM PFOA + 1µM PFHpA) -0.0596480 0.0732649 35 -0.8141405 0.8876673
1% Methanol - (1µM PFOA + 1µM PFPA) -0.0952799 0.0732649 35 -1.3004844 0.5943451
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA) 0.0493384 0.0732649 35 0.6734240 0.9400115
Table 20 Env Factor = 20
contrast estimate SE df t.ratio p.value
1% Methanol - (1µM PFHpA + 1µM PFPA) -0.0933796 0.0647766 35 -1.441566 0.4981177
1% Methanol - (1µM PFOA + 1µM PFHpA) -0.1542739 0.0647766 35 -2.381632 0.0881492
1% Methanol - (1µM PFOA + 1µM PFPA) -0.1140989 0.0647766 35 -1.761423 0.3048625
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA) 0.0661260 0.0647766 35 1.020833 0.7789758
Table 20 Env Factor = 25
contrast estimate SE df t.ratio p.value
1% Methanol - (1µM PFHpA + 1µM PFPA) -0.1788673 0.0635622 35 -2.8140523 0.0315178
1% Methanol - (1µM PFOA + 1µM PFHpA) -0.1631865 0.0635622 35 -2.5673525 0.0574357
1% Methanol - (1µM PFOA + 1µM PFPA) -0.1634161 0.0635622 35 -2.5709644 0.0569471
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA) -0.0466501 0.0635622 35 -0.7339279 0.9198257