Background

… Regarding the data contained under “Please compare 400uM treatment group for each PFAS to 1% methanol 400uM group & please compare every other treatment group for each PFAS chemical to 1% methanol group”, could we also compare every other treatment group for each PFAS (in PDP groups) to the PFAS + 400uM (no PDP) group?

… Regarding the data contained under “Please compare 400uM treatment group for each PFAS to 1% methanol 400uM group & please compare every other treatment group for each PFAS chemical to 1% methanol group”, could we also compare every other treatment group for each PFAS (in PDP groups) to the PFAS + 400uM (no PDP) group?

Please test for interaction effect for photosensitizer and Carboplatin

  • sensitizer: BDP or ALA
  • Carboplatin: NT vs 100 uM
    • May add other dose levels later
  • analysis separately for each cell line (Caov-3/ OVCAR-3) and each PFAS (PFOA, …)

Caov-3 500 PFOA PDP

Table: Caov-3 500 PFOA PDP
Estimate Std. Error t value Pr(>|t|)
(Intercept) 0.772 0.039 19.634 0.000
Plate2 0.056 0.039 1.427 0.171
Plate3 -0.086 0.039 -2.181 0.043
PhotosensitizerBPD-PDP -0.303 0.045 -6.667 0.000
CarboplatinPDP Only 0.331 0.045 7.286 0.000
PhotosensitizerBPD-PDP:CarboplatinPDP Only 0.149 0.064 2.327 0.032
Table (no Carboplatin): Caov-3 500 PFOA PDP
Estimate Std. Error t value Pr(>|t|)
(Intercept) 1.062 0.057 18.519 0.000
Plate2 0.121 0.070 1.727 0.122
Plate3 -0.026 0.070 -0.370 0.721
PhotosensitizerBPD-PDP -0.153 0.057 -2.675 0.028
Table (Carboplatin 100 uM): Caov-3 500 PFOA PDP
Estimate Std. Error t value Pr(>|t|)
(Intercept) 0.814 0.022 37.011 0.000
Plate2 -0.009 0.027 -0.334 0.747
Plate3 -0.146 0.027 -5.405 0.001
PhotosensitizerBPD-PDP -0.303 0.022 -13.769 0.000

[1] 22

Caov-3 2uM PFOA PDP

Table: Caov-3 2uM PFOA PDP
Estimate Std. Error t value Pr(>|t|)
(Intercept) 0.748 0.082 9.140 0.000
Plate2 0.151 0.082 1.846 0.081
Plate3 -0.115 0.082 -1.401 0.178
PhotosensitizerBPD-PDP -0.269 0.094 -2.842 0.011
CarboplatinPDP Only 0.474 0.094 5.015 0.000
PhotosensitizerBPD-PDP:CarboplatinPDP Only 0.010 0.134 0.072 0.943
Table (no Carboplatin): Caov-3 2uM PFOA PDP
Estimate Std. Error t value Pr(>|t|)
(Intercept) 1.152 0.112 10.247 0.000
Plate2 0.330 0.138 2.396 0.043
Plate3 -0.085 0.138 -0.620 0.552
PhotosensitizerBPD-PDP -0.259 0.112 -2.302 0.050
Table (Carboplatin 100 uM): Caov-3 2uM PFOA PDP
Estimate Std. Error t value Pr(>|t|)
(Intercept) 0.817 0.036 22.672 0.000
Plate2 -0.028 0.044 -0.631 0.546
Plate3 -0.144 0.044 -3.258 0.012
PhotosensitizerBPD-PDP -0.269 0.036 -7.450 0.000

[1] 23

Caov-3 500 PFHpA PDP

Table: Caov-3 500 PFHpA PDP
Estimate Std. Error t value Pr(>|t|)
(Intercept) 0.744 0.064 11.688 0.000
Plate2 0.017 0.064 0.261 0.797
Plate3 -0.044 0.064 -0.687 0.501
PhotosensitizerBPD-PDP -0.208 0.074 -2.827 0.011
CarboplatinPDP Only 0.394 0.074 5.359 0.000
PhotosensitizerBPD-PDP:CarboplatinPDP Only 0.097 0.104 0.932 0.364
Table (no Carboplatin): Caov-3 500 PFHpA PDP
Estimate Std. Error t value Pr(>|t|)
(Intercept) 1.134 0.088 12.863 0.000
Plate2 0.020 0.108 0.183 0.860
Plate3 -0.034 0.108 -0.316 0.760
PhotosensitizerBPD-PDP -0.111 0.088 -1.259 0.244
Table (Carboplatin 100 uM): Caov-3 500 PFHpA PDP
Estimate Std. Error t value Pr(>|t|)
(Intercept) 0.749 0.066 11.317 0.000
Plate2 0.014 0.081 0.167 0.871
Plate3 -0.053 0.081 -0.659 0.528
PhotosensitizerBPD-PDP -0.208 0.066 -3.143 0.014

Caov-3 2uM PFHpA PDP

Table: Caov-3 2uM PFHpA PDP
Estimate Std. Error t value Pr(>|t|)
(Intercept) 0.735 0.047 15.514 0.000
Plate2 0.000 0.047 0.010 0.992
Plate3 -0.088 0.047 -1.850 0.081
PhotosensitizerBPD-PDP -0.258 0.055 -4.709 0.000
CarboplatinPDP Only 0.324 0.055 5.918 0.000
PhotosensitizerBPD-PDP:CarboplatinPDP Only 0.191 0.077 2.471 0.024
Table (no Carboplatin): Caov-3 2uM PFHpA PDP
Estimate Std. Error t value Pr(>|t|)
(Intercept) 1.063 0.076 13.914 0.000
Plate2 -0.005 0.094 -0.049 0.962
Plate3 -0.096 0.094 -1.029 0.333
PhotosensitizerBPD-PDP -0.066 0.076 -0.869 0.410
Table (Carboplatin 100 uM): Caov-3 2uM PFHpA PDP
Estimate Std. Error t value Pr(>|t|)
(Intercept) 0.730 0.030 24.616 0.000
Plate2 0.006 0.036 0.152 0.883
Plate3 -0.079 0.036 -2.171 0.062
PhotosensitizerBPD-PDP -0.258 0.030 -8.681 0.000

Caov-3 500nM PFPA PDP

Table: Caov-3 500nM PFPA PDP
Estimate Std. Error t value Pr(>|t|)
(Intercept) 0.653 0.050 13.088 0.000
Plate2 -0.025 0.050 -0.496 0.626
Plate3 -0.122 0.050 -2.435 0.026
PhotosensitizerBPD-PDP -0.075 0.058 -1.303 0.209
CarboplatinPDP Only 0.437 0.058 7.576 0.000
PhotosensitizerBPD-PDP:CarboplatinPDP Only 0.064 0.082 0.781 0.445
Table (no Carboplatin): Caov-3 500nM PFPA PDP
Estimate Std. Error t value Pr(>|t|)
(Intercept) 1.140 0.063 18.009 0.000
Plate2 -0.095 0.078 -1.231 0.253
Plate3 -0.201 0.078 -2.587 0.032
PhotosensitizerBPD-PDP -0.011 0.063 -0.181 0.861
Table (Carboplatin 100 uM): Caov-3 500nM PFPA PDP
Estimate Std. Error t value Pr(>|t|)
(Intercept) 0.604 0.047 12.831 0.000
Plate2 0.046 0.058 0.797 0.448
Plate3 -0.042 0.058 -0.737 0.482
PhotosensitizerBPD-PDP -0.075 0.047 -1.597 0.149

Caov-3 2uM PFPA PDP

Table: Caov-3 2uM PFPA PDP
Estimate Std. Error t value Pr(>|t|)
(Intercept) 0.691 0.048 14.283 0.000
Plate2 -0.108 0.048 -2.224 0.039
Plate3 -0.198 0.048 -4.094 0.001
PhotosensitizerBPD-PDP -0.164 0.056 -2.932 0.009
CarboplatinPDP Only 0.417 0.056 7.463 0.000
PhotosensitizerBPD-PDP:CarboplatinPDP Only 0.118 0.079 1.494 0.152
Table (no Carboplatin): Caov-3 2uM PFPA PDP
Estimate Std. Error t value Pr(>|t|)
(Intercept) 1.158 0.068 16.964 0.000
Plate2 -0.149 0.084 -1.784 0.112
Plate3 -0.306 0.084 -3.666 0.006
PhotosensitizerBPD-PDP -0.046 0.068 -0.671 0.521
Table (Carboplatin 100 uM): Caov-3 2uM PFPA PDP
Estimate Std. Error t value Pr(>|t|)
(Intercept) 0.641 0.019 33.406 0.000
Plate2 -0.066 0.023 -2.811 0.023
Plate3 -0.090 0.023 -3.814 0.005
PhotosensitizerBPD-PDP -0.164 0.019 -8.537 0.000

Caov-3 PFOA + PFHpA PDP

Table: Caov-3 PFOA + PFHpA PDP
Estimate Std. Error t value Pr(>|t|)
(Intercept) 0.432 0.043 9.939 0.000
Plate2 0.028 0.046 0.602 0.550
Plate3 0.062 0.046 1.331 0.191
Plate4 0.019 0.046 0.414 0.681
PhotosensitizerBPD-PDP 0.011 0.046 0.234 0.816
CarboplatinPDP Only 0.586 0.046 12.614 0.000
PhotosensitizerBPD-PDP:CarboplatinPDP Only -0.156 0.066 -2.378 0.022
Table (no Carboplatin): Caov-3 PFOA + PFHpA PDP
Estimate Std. Error t value Pr(>|t|)
(Intercept) 0.989 0.060 16.487 0.000
Plate2 0.039 0.076 0.511 0.615
Plate3 0.134 0.076 1.763 0.094
Plate4 0.056 0.076 0.734 0.472
PhotosensitizerBPD-PDP -0.145 0.054 -2.711 0.014
Table (Carboplatin 100 uM): Caov-3 PFOA + PFHpA PDP
Estimate Std. Error t value Pr(>|t|)
(Intercept) 0.462 0.043 10.802 0.000
Plate2 0.017 0.054 0.318 0.754
Plate3 -0.010 0.054 -0.185 0.855
Plate4 -0.017 0.054 -0.318 0.754
PhotosensitizerBPD-PDP 0.011 0.038 0.285 0.779

Caov-3 PFOA + PFPA PDP

Table: Caov-3 PFOA + PFPA PDP
Estimate Std. Error t value Pr(>|t|)
(Intercept) 0.482 0.044 11.056 0.000
Plate2 -0.001 0.047 -0.015 0.988
Plate3 0.027 0.047 0.577 0.567
Plate4 -0.042 0.047 -0.908 0.369
PhotosensitizerBPD-PDP -0.074 0.047 -1.593 0.119
CarboplatinPDP Only 0.585 0.047 12.545 0.000
PhotosensitizerBPD-PDP:CarboplatinPDP Only -0.184 0.066 -2.794 0.008
Table (no Carboplatin): Caov-3 PFOA + PFPA PDP
Estimate Std. Error t value Pr(>|t|)
(Intercept) 1.025 0.048 21.225 0.000
Plate2 0.065 0.061 1.070 0.298
Plate3 0.069 0.061 1.137 0.270
Plate4 0.017 0.061 0.282 0.781
PhotosensitizerBPD-PDP -0.259 0.043 -5.985 0.000
Table (Carboplatin 100 uM): Caov-3 PFOA + PFPA PDP
Estimate Std. Error t value Pr(>|t|)
(Intercept) 0.524 0.056 9.292 0.000
Plate2 -0.067 0.071 -0.936 0.361
Plate3 -0.016 0.071 -0.219 0.829
Plate4 -0.102 0.071 -1.427 0.170
PhotosensitizerBPD-PDP -0.074 0.050 -1.472 0.157

Caov-3 PFHpA + PFPA PDP

Table: Caov-3 PFHpA + PFPA PDP
Estimate Std. Error t value Pr(>|t|)
(Intercept) 0.531 0.054 9.843 0.000
Plate2 -0.115 0.058 -1.987 0.054
Plate3 0.064 0.058 1.117 0.271
Plate4 -0.097 0.058 -1.688 0.099
PhotosensitizerBPD-PDP -0.083 0.058 -1.445 0.156
CarboplatinPDP Only 0.543 0.058 9.406 0.000
PhotosensitizerBPD-PDP:CarboplatinPDP Only -0.146 0.082 -1.793 0.080
Table (no Carboplatin): Caov-3 PFHpA + PFPA PDP
Estimate Std. Error t value Pr(>|t|)
(Intercept) 1.048 0.075 14.029 0.000
Plate2 -0.024 0.095 -0.249 0.806
Plate3 0.080 0.095 0.845 0.409
Plate4 -0.102 0.095 -1.082 0.293
PhotosensitizerBPD-PDP -0.230 0.067 -3.436 0.003
Table (Carboplatin 100 uM): Caov-3 PFHpA + PFPA PDP
Estimate Std. Error t value Pr(>|t|)
(Intercept) 0.557 0.051 10.901 0.000
Plate2 -0.206 0.065 -3.185 0.005
Plate3 0.049 0.065 0.758 0.458
Plate4 -0.092 0.065 -1.432 0.168
PhotosensitizerBPD-PDP -0.083 0.046 -1.825 0.084

Caov-3 3 Mix PDP

Table: Caov-3 3 Mix PDP
Estimate Std. Error t value Pr(>|t|)
(Intercept) 0.509 0.038 13.271 0.000
Plate2 -0.043 0.041 -1.046 0.302
Plate3 -0.071 0.041 -1.742 0.089
Plate4 -0.081 0.041 -1.977 0.055
PhotosensitizerBPD-PDP -0.074 0.041 -1.797 0.080
CarboplatinPDP Only 0.582 0.041 14.213 0.000
PhotosensitizerBPD-PDP:CarboplatinPDP Only -0.096 0.058 -1.661 0.104
Table (no Carboplatin): Caov-3 3 Mix PDP
Estimate Std. Error t value Pr(>|t|)
(Intercept) 1.066 0.051 21.064 0.000
Plate2 -0.002 0.064 -0.025 0.980
Plate3 -0.047 0.064 -0.738 0.469
Plate4 -0.048 0.064 -0.750 0.462
PhotosensitizerBPD-PDP -0.170 0.045 -3.751 0.001
Table (Carboplatin 100 uM): Caov-3 3 Mix PDP
Estimate Std. Error t value Pr(>|t|)
(Intercept) 0.533 0.043 12.432 0.000
Plate2 -0.084 0.054 -1.551 0.137
Plate3 -0.095 0.054 -1.760 0.094
Plate4 -0.114 0.054 -2.100 0.049
PhotosensitizerBPD-PDP -0.074 0.038 -1.919 0.070

OVCAR-3 500nM PFOA PDP

Table: OVCAR-3 500nM PFOA PDP
Estimate Std. Error t value Pr(>|t|)
(Intercept) 0.137 0.035 3.924 0.001
Plate2 0.050 0.035 1.432 0.167
Plate3 0.030 0.035 0.871 0.394
Plate4 0.058 0.045 1.283 0.213
PhotosensitizerBPD-PDP -0.026 0.039 -0.659 0.517
CarboplatinPDP Only 0.825 0.040 20.420 0.000
PhotosensitizerBPD-PDP:CarboplatinPDP Only -0.105 0.053 -1.958 0.064
Table (no Carboplatin): OVCAR-3 500nM PFOA PDP
Estimate Std. Error t value Pr(>|t|)
(Intercept) 0.970 0.045 21.378 0.000
Plate2 0.074 0.056 1.325 0.218
Plate3 -0.016 0.056 -0.289 0.779
Plate4 -0.020 0.072 -0.278 0.787
PhotosensitizerBPD-PDP -0.113 0.045 -2.487 0.035
Table (Carboplatin 100 uM): OVCAR-3 500nM PFOA PDP
Estimate Std. Error t value Pr(>|t|)
(Intercept) 0.130 0.021 6.112 0.000
Plate2 0.027 0.026 1.025 0.332
Plate3 0.077 0.026 2.964 0.016
Plate4 0.136 0.034 4.051 0.003
PhotosensitizerBPD-PDP -0.043 0.021 -2.043 0.071

[1] 32

OVCAR-3 2uM PFOA PDP

Table: OVCAR-3 2uM PFOA PDP
Estimate Std. Error t value Pr(>|t|)
(Intercept) 0.145 0.031 4.688 0.000
Plate2 0.055 0.031 1.791 0.088
Plate3 0.004 0.031 0.118 0.907
Plate4 -0.054 0.040 -1.349 0.192
PhotosensitizerBPD-PDP 0.017 0.035 0.491 0.629
CarboplatinPDP Only 0.823 0.036 23.043 0.000
PhotosensitizerBPD-PDP:CarboplatinPDP Only -0.127 0.047 -2.698 0.013
Table (no Carboplatin): OVCAR-3 2uM PFOA PDP
Estimate Std. Error t value Pr(>|t|)
(Intercept) 0.947 0.043 22.088 0.000
Plate2 0.072 0.052 1.363 0.206
Plate3 0.051 0.052 0.981 0.352
Plate4 -0.024 0.068 -0.354 0.732
PhotosensitizerBPD-PDP -0.113 0.043 -2.628 0.027
Table (Carboplatin 100 uM): OVCAR-3 2uM PFOA PDP
Estimate Std. Error t value Pr(>|t|)
(Intercept) 0.166 0.028 5.952 0.000
Plate2 0.039 0.034 1.146 0.281
Plate3 -0.044 0.034 -1.290 0.229
Plate4 -0.084 0.044 -1.896 0.091
PhotosensitizerBPD-PDP 0.019 0.028 0.684 0.511

[1] 33

OVCAR-3 500 PFHpA PDP

Table: OVCAR-3 500 PFHpA PDP
Estimate Std. Error t value Pr(>|t|)
(Intercept) 0.138 0.040 3.419 0.003
Plate2 0.088 0.040 2.174 0.041
Plate3 0.107 0.040 2.639 0.015
Plate4 0.057 0.052 1.099 0.284
PhotosensitizerBPD-PDP -0.035 0.045 -0.779 0.445
CarboplatinPDP Only 0.854 0.047 18.281 0.000
PhotosensitizerBPD-PDP:CarboplatinPDP Only -0.069 0.062 -1.120 0.275
Table (no Carboplatin): OVCAR-3 500 PFHpA PDP
Estimate Std. Error t value Pr(>|t|)
(Intercept) 0.947 0.032 29.241 0.000
Plate2 0.193 0.040 4.856 0.001
Plate3 0.141 0.040 3.545 0.006
Plate4 0.023 0.051 0.443 0.668
PhotosensitizerBPD-PDP -0.084 0.032 -2.603 0.029
Table (Carboplatin 100 uM): OVCAR-3 500 PFHpA PDP
Estimate Std. Error t value Pr(>|t|)
(Intercept) 0.184 0.040 4.563 0.001
Plate2 -0.017 0.050 -0.335 0.746
Plate3 0.073 0.050 1.476 0.174
Plate4 0.092 0.064 1.442 0.183
PhotosensitizerBPD-PDP -0.055 0.040 -1.371 0.203

OVCAR-3 2uM PFHpA PDP

Table: OVCAR-3 2uM PFHpA PDP
Estimate Std. Error t value Pr(>|t|)
(Intercept) 0.184 0.039 4.723 0.000
Plate2 0.005 0.039 0.126 0.901
Plate3 0.008 0.039 0.209 0.837
Plate4 0.017 0.050 0.338 0.739
PhotosensitizerBPD-PDP -0.025 0.044 -0.573 0.573
CarboplatinPDP Only 0.742 0.045 16.457 0.000
PhotosensitizerBPD-PDP:CarboplatinPDP Only 0.027 0.060 0.458 0.652
Table (no Carboplatin): OVCAR-3 2uM PFHpA PDP
Estimate Std. Error t value Pr(>|t|)
(Intercept) 0.945 0.037 25.282 0.000
Plate2 0.020 0.046 0.439 0.671
Plate3 -0.064 0.046 -1.394 0.197
Plate4 -0.103 0.059 -1.741 0.116
PhotosensitizerBPD-PDP 0.028 0.037 0.736 0.480
Table (Carboplatin 100 uM): OVCAR-3 2uM PFHpA PDP
Estimate Std. Error t value Pr(>|t|)
(Intercept) 0.166 0.030 5.439 0.000
Plate2 -0.010 0.037 -0.276 0.788
Plate3 0.080 0.037 2.151 0.060
Plate4 0.137 0.048 2.847 0.019
PhotosensitizerBPD-PDP -0.050 0.030 -1.652 0.133

OVCAR-3 500 PFPA PDP

Table: OVCAR-3 500 PFPA PDP
Estimate Std. Error t value Pr(>|t|)
(Intercept) 0.178 0.037 4.878 0.000
Plate2 0.021 0.037 0.582 0.566
Plate3 0.045 0.037 1.225 0.234
Plate4 0.004 0.047 0.077 0.939
PhotosensitizerBPD-PDP -0.016 0.041 -0.402 0.692
CarboplatinPDP Only 0.767 0.042 18.200 0.000
PhotosensitizerBPD-PDP:CarboplatinPDP Only 0.002 0.056 0.039 0.969
Table (no Carboplatin): OVCAR-3 500 PFPA PDP
Estimate Std. Error t value Pr(>|t|)
(Intercept) 0.934 0.030 31.320 0.000
Plate2 0.058 0.037 1.590 0.146
Plate3 0.043 0.037 1.169 0.273
Plate4 -0.118 0.047 -2.504 0.034
PhotosensitizerBPD-PDP 0.019 0.030 0.641 0.537
Table (Carboplatin 100 uM): OVCAR-3 500 PFPA PDP
Estimate Std. Error t value Pr(>|t|)
(Intercept) 0.190 0.032 5.995 0.000
Plate2 -0.016 0.039 -0.401 0.698
Plate3 0.047 0.039 1.207 0.258
Plate4 0.125 0.050 2.505 0.034
PhotosensitizerBPD-PDP -0.050 0.032 -1.572 0.151

OVCAR-3 2uM PFPA PDP

Table: OVCAR-3 2uM PFPA PDP
Estimate Std. Error t value Pr(>|t|)
(Intercept) 0.157 0.042 3.733 0.001
Plate2 0.033 0.042 0.785 0.441
Plate3 0.031 0.042 0.741 0.467
Plate4 -0.012 0.054 -0.218 0.830
PhotosensitizerBPD-PDP 0.007 0.047 0.156 0.877
CarboplatinPDP Only 0.806 0.049 16.595 0.000
PhotosensitizerBPD-PDP:CarboplatinPDP Only -0.073 0.064 -1.132 0.270
Table (no Carboplatin): OVCAR-3 2uM PFPA PDP
Estimate Std. Error t value Pr(>|t|)
(Intercept) 0.963 0.050 19.116 0.000
Plate2 0.068 0.062 1.109 0.296
Plate3 -0.002 0.062 -0.029 0.978
Plate4 -0.139 0.080 -1.751 0.114
PhotosensitizerBPD-PDP -0.033 0.050 -0.662 0.525
Table (Carboplatin 100 uM): OVCAR-3 2uM PFPA PDP
Estimate Std. Error t value Pr(>|t|)
(Intercept) 0.158 0.021 7.444 0.000
Plate2 -0.002 0.026 -0.088 0.932
Plate3 0.064 0.026 2.468 0.036
Plate4 0.116 0.034 3.452 0.007
PhotosensitizerBPD-PDP -0.025 0.021 -1.167 0.273

OVCAR-3 PFOA + PFHpA PDP

Table: OVCAR-3 PFOA + PFHpA PDP
Estimate Std. Error t value Pr(>|t|)
(Intercept) 0.270 0.075 3.609 0.001
Plate2 -0.130 0.084 -1.554 0.130
Plate3 0.042 0.084 0.494 0.624
Plate4 0.072 0.084 0.852 0.400
PhotosensitizerBPD-PDP -0.163 0.086 -1.904 0.066
CarboplatinPDP Only 0.830 0.077 10.824 0.000
PhotosensitizerBPD-PDP:CarboplatinPDP Only -0.186 0.121 -1.539 0.133
Table (no Carboplatin): OVCAR-3 PFOA + PFHpA PDP
Estimate Std. Error t value Pr(>|t|)
(Intercept) 1.024 0.077 13.218 0.000
Plate2 -0.109 0.101 -1.072 0.301
Plate3 0.068 0.101 0.673 0.511
Plate4 0.324 0.101 3.193 0.006
PhotosensitizerBPD-PDP -0.350 0.073 -4.776 0.000
Table (Carboplatin 100 uM): OVCAR-3 PFOA + PFHpA PDP
Estimate Std. Error t value Pr(>|t|)
(Intercept) 0.345 0.074 4.642 0.000
Plate2 -0.152 0.097 -1.565 0.139
Plate3 0.015 0.097 0.152 0.881
Plate4 -0.181 0.097 -1.859 0.083
PhotosensitizerBPD-PDP -0.163 0.070 -2.324 0.035

OVCAR-3 PFOA + PFPA PDP

Table: OVCAR-3 PFOA + PFPA PDP
Estimate Std. Error t value Pr(>|t|)
(Intercept) 0.323 0.083 3.904 0.000
Plate2 -0.159 0.093 -1.712 0.096
Plate3 0.021 0.093 0.230 0.819
Plate4 0.003 0.093 0.031 0.976
PhotosensitizerBPD-PDP -0.198 0.095 -2.091 0.044
CarboplatinPDP Only 0.787 0.085 9.274 0.000
PhotosensitizerBPD-PDP:CarboplatinPDP Only -0.080 0.134 -0.593 0.557
Table (no Carboplatin): OVCAR-3 PFOA + PFPA PDP
Estimate Std. Error t value Pr(>|t|)
(Intercept) 1.021 0.094 10.906 0.000
Plate2 -0.095 0.123 -0.772 0.452
Plate3 0.084 0.123 0.689 0.501
Plate4 0.229 0.123 1.866 0.082
PhotosensitizerBPD-PDP -0.278 0.088 -3.140 0.007
Table (Carboplatin 100 uM): OVCAR-3 PFOA + PFPA PDP
Estimate Std. Error t value Pr(>|t|)
(Intercept) 0.411 0.095 4.321 0.001
Plate2 -0.224 0.125 -1.795 0.093
Plate3 -0.042 0.125 -0.334 0.743
Plate4 -0.223 0.125 -1.790 0.094
PhotosensitizerBPD-PDP -0.198 0.090 -2.206 0.043

OVCAR-3 PFHpA + PFPA PDP

Table: OVCAR-3 PFHpA + PFPA PDP
Estimate Std. Error t value Pr(>|t|)
(Intercept) 0.338 0.074 4.593 0.000
Plate2 -0.177 0.083 -2.146 0.039
Plate3 0.010 0.083 0.121 0.904
Plate4 -0.069 0.083 -0.839 0.408
PhotosensitizerBPD-PDP -0.177 0.084 -2.095 0.044
CarboplatinPDP Only 0.792 0.075 10.494 0.000
PhotosensitizerBPD-PDP:CarboplatinPDP Only -0.076 0.119 -0.636 0.529
Table (no Carboplatin): OVCAR-3 PFHpA + PFPA PDP
Estimate Std. Error t value Pr(>|t|)
(Intercept) 1.087 0.085 12.843 0.000
Plate2 -0.151 0.111 -1.363 0.193
Plate3 0.012 0.111 0.110 0.914
Plate4 0.070 0.111 0.633 0.536
PhotosensitizerBPD-PDP -0.253 0.080 -3.157 0.007
Table (Carboplatin 100 uM): OVCAR-3 PFHpA + PFPA PDP
Estimate Std. Error t value Pr(>|t|)
(Intercept) 0.380 0.091 4.162 0.001
Plate2 -0.204 0.119 -1.705 0.109
Plate3 0.008 0.119 0.066 0.948
Plate4 -0.209 0.119 -1.748 0.101
PhotosensitizerBPD-PDP -0.177 0.086 -2.050 0.058

OVCAR-3 3 Mix PDP

Table: OVCAR-3 3 Mix PDP
Estimate Std. Error t value Pr(>|t|)
(Intercept) 0.104 0.099 1.051 0.303
Plate2 -0.063 0.106 -0.599 0.554
Plate3 0.042 0.106 0.393 0.698
Plate4 0.068 0.106 0.644 0.526
PhotosensitizerBPD-PDP -0.014 0.106 -0.130 0.898
CarboplatinPDP Only 0.976 0.106 9.224 0.000
PhotosensitizerBPD-PDP:CarboplatinPDP Only -0.266 0.150 -1.781 0.087
Table (no Carboplatin): OVCAR-3 3 Mix PDP
Estimate Std. Error t value Pr(>|t|)
(Intercept) 1.059 0.171 6.193 0.000
Plate2 -0.117 0.216 -0.543 0.598
Plate3 0.109 0.216 0.503 0.625
Plate4 0.138 0.216 0.638 0.536
PhotosensitizerBPD-PDP -0.280 0.153 -1.831 0.094
Table (Carboplatin 100 uM): OVCAR-3 3 Mix PDP
Estimate Std. Error t value Pr(>|t|)
(Intercept) 0.125 0.012 10.165 0.000
Plate2 -0.009 0.016 -0.606 0.557
Plate3 -0.026 0.016 -1.645 0.128
Plate4 -0.002 0.016 -0.119 0.907
PhotosensitizerBPD-PDP -0.014 0.011 -1.249 0.238