PDT Data

Please compare 400uM treatment group for each PFAS to 1% methanol 400uM group & please compare every other treatment group for each PFAS chemical to 1% methanol group

Caov-3 PFAS BPD JC-1

Table 49 400uM treatment group

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFHpA	-0.8149384	0.1466225	31	-5.558071	0.0000260
1% Methanol - 2µM PFOA	-0.6423158	0.1466225	31	-4.380744	0.0007529
1% Methanol - 2µM PFPA	-0.6830326	0.1466225	31	-4.658443	0.0003422
1% Methanol - 500nM PFHpA	-0.8297193	0.1466225	31	-5.658880	0.0000195
1% Methanol - 500nM PFOA	-0.7937792	0.1466225	31	-5.413761	0.0000393
1% Methanol - 500nM PFPA	-0.7201158	0.1466225	31	-4.911359	0.0001661

Table 49 Treatment Group = 400µM

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFHpA	-0.8149384	0.1466225	31	-5.558071	0.0000260
1% Methanol - 2µM PFOA	-0.6423158	0.1466225	31	-4.380744	0.0007529
1% Methanol - 2µM PFPA	-0.6830326	0.1466225	31	-4.658443	0.0003422
1% Methanol - 500nM PFHpA	-0.8297193	0.1466225	31	-5.658880	0.0000195
1% Methanol - 500nM PFOA	-0.7937792	0.1466225	31	-5.413761	0.0000393
1% Methanol - 500nM PFPA	-0.7201158	0.1466225	31	-4.911359	0.0001661

Table 49 Treatment Group = PDP + 100µM

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFHpA	-0.4015443	0.1101322	31	-3.646021	0.0057850
1% Methanol - 2µM PFOA	-0.4869168	0.1101322	31	-4.421202	0.0006714
1% Methanol - 2µM PFPA	-0.4916081	0.1101322	31	-4.463799	0.0005951
1% Methanol - 500nM PFHpA	-0.6468002	0.1101322	31	-5.872943	0.0000106
1% Methanol - 500nM PFOA	-0.3904948	0.1101322	31	-3.545691	0.0075812
1% Methanol - 500nM PFPA	-0.4911098	0.1101322	31	-4.459275	0.0006028

Table 49 Treatment Group = PDP + 200µM

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFHpA	-0.5451585	0.0966299	31	-5.641715	0.0000205
1% Methanol - 2µM PFOA	-0.5933556	0.0966299	31	-6.140494	0.0000049
1% Methanol - 2µM PFPA	-0.4751728	0.0966299	31	-4.917449	0.0001632
1% Methanol - 500nM PFHpA	-0.7596645	0.0966299	31	-7.861585	0.0000000
1% Methanol - 500nM PFOA	-0.5293753	0.0966299	31	-5.478377	0.0000327
1% Methanol - 500nM PFPA	-0.4664165	0.0966299	31	-4.826832	0.0002116

Table 49 Treatment Group = PDP + 400µM

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFHpA	-0.5735358	0.089344	31	-6.419409	0.0000022
1% Methanol - 2µM PFOA	-0.5723573	0.089344	31	-6.406219	0.0000023
1% Methanol - 2µM PFPA	-0.4898384	0.089344	31	-5.482610	0.0000323
1% Methanol - 500nM PFHpA	-0.7028169	0.089344	31	-7.866413	0.0000000
1% Methanol - 500nM PFOA	-0.4434080	0.089344	31	-4.962929	0.0001433
1% Methanol - 500nM PFPA	-0.4580835	0.089344	31	-5.127188	0.0000895

[1] 50

Caov-3 PFAS ALA JC-1

Table 50 400uM treatment group

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFHpA	-0.4924132	0.1638238	31	-3.005749	0.0308685
1% Methanol - 2µM PFOA	-0.3644991	0.1638238	31	-2.224946	0.1848864
1% Methanol - 2µM PFPA	-0.5397223	0.1638238	31	-3.294530	0.0147420
1% Methanol - 500nM PFHpA	-0.4785700	0.1638238	31	-2.921249	0.0380825
1% Methanol - 500nM PFOA	-0.4795685	0.1638238	31	-2.927344	0.0375139
1% Methanol - 500nM PFPA	-0.6039559	0.1638238	31	-3.686619	0.0051818

Table 50 Treatment Group = 400µM

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFHpA	-0.4924132	0.1638238	31	-3.005749	0.0308685
1% Methanol - 2µM PFOA	-0.3644991	0.1638238	31	-2.224946	0.1848864
1% Methanol - 2µM PFPA	-0.5397223	0.1638238	31	-3.294530	0.0147420
1% Methanol - 500nM PFHpA	-0.4785700	0.1638238	31	-2.921249	0.0380825
1% Methanol - 500nM PFOA	-0.4795685	0.1638238	31	-2.927344	0.0375139
1% Methanol - 500nM PFPA	-0.6039559	0.1638238	31	-3.686619	0.0051818

Table 50 Treatment Group = PDP + 100µM

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFHpA	-0.4303218	0.0897559	31	-4.794357	0.0002321
1% Methanol - 2µM PFOA	-0.3729848	0.0897559	31	-4.155545	0.0014190
1% Methanol - 2µM PFPA	-0.5211922	0.0897559	31	-5.806773	0.0000128
1% Methanol - 500nM PFHpA	-0.3658847	0.0897559	31	-4.076441	0.0017702
1% Methanol - 500nM PFOA	-0.4853938	0.0897559	31	-5.407931	0.0000400
1% Methanol - 500nM PFPA	-0.4531043	0.0897559	31	-5.048183	0.0001122

Table 50 Treatment Group = PDP + 200µM

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFHpA	-0.4320440	0.0809127	31	-5.339634	0.0000487
1% Methanol - 2µM PFOA	-0.3806476	0.0809127	31	-4.704426	0.0003001
1% Methanol - 2µM PFPA	-0.5188848	0.0809127	31	-6.412899	0.0000023
1% Methanol - 500nM PFHpA	-0.4614199	0.0809127	31	-5.702691	0.0000172
1% Methanol - 500nM PFOA	-0.4904372	0.0809127	31	-6.061315	0.0000062
1% Methanol - 500nM PFPA	-0.4222644	0.0809127	31	-5.218768	0.0000688

Table 50 Treatment Group = PDP + 400µM

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFHpA	-0.5116721	0.0940338	31	-5.441361	0.0000363
1% Methanol - 2µM PFOA	-0.5440021	0.0940338	31	-5.785174	0.0000136
1% Methanol - 2µM PFPA	-0.6096170	0.0940338	31	-6.482953	0.0000019
1% Methanol - 500nM PFHpA	-0.5628813	0.0940338	31	-5.985944	0.0000077
1% Methanol - 500nM PFOA	-0.5466874	0.0940338	31	-5.813730	0.0000125
1% Methanol - 500nM PFPA	-0.4085874	0.0940338	31	-4.345110	0.0008326

[1] 51

Caov-3 Mix BPD JC-1

Table 51 400uM treatment group

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - (1µM PFHpA + 1µM PFPA)	-0.6825203	0.0846552	21	-8.062359	3.00e-07
1% Methanol - (1µM PFOA + 1µM PFHpA)	-0.5008947	0.0846552	21	-5.916883	2.85e-05
1% Methanol - (1µM PFOA + 1µM PFPA)	-0.7039559	0.0846552	21	-8.315569	2.00e-07
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA)	-0.6909629	0.0846552	21	-8.162088	2.00e-07

Table 51 Treatment Group = 400µM

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - (1µM PFHpA + 1µM PFPA)	-0.6825203	0.0846552	21	-8.062359	3.00e-07
1% Methanol - (1µM PFOA + 1µM PFHpA)	-0.5008947	0.0846552	21	-5.916883	2.85e-05
1% Methanol - (1µM PFOA + 1µM PFPA)	-0.7039559	0.0846552	21	-8.315569	2.00e-07
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA)	-0.6909629	0.0846552	21	-8.162088	2.00e-07

Table 51 Treatment Group = PDP + 100µM

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - (1µM PFHpA + 1µM PFPA)	-0.4793093	0.0542867	21	-8.829218	1.0e-07
1% Methanol - (1µM PFOA + 1µM PFHpA)	-0.4457252	0.0542867	21	-8.210576	2.0e-07
1% Methanol - (1µM PFOA + 1µM PFPA)	-0.3973896	0.0542867	21	-7.320199	1.3e-06
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA)	-0.4431461	0.0542867	21	-8.163068	2.0e-07

Table 51 Treatment Group = PDP + 200µM

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - (1µM PFHpA + 1µM PFPA)	-0.4898923	0.05785	21	-8.468325	1.0e-07
1% Methanol - (1µM PFOA + 1µM PFHpA)	-0.4968750	0.05785	21	-8.589028	1.0e-07
1% Methanol - (1µM PFOA + 1µM PFPA)	-0.4138282	0.05785	21	-7.153474	1.9e-06
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA)	-0.3746009	0.05785	21	-6.475387	8.2e-06

Table 51 Treatment Group = PDP + 400µM

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - (1µM PFHpA + 1µM PFPA)	-0.5977054	0.0674381	21	-8.863023	1e-07
1% Methanol - (1µM PFOA + 1µM PFHpA)	-0.5552163	0.0674381	21	-8.232976	2e-07
1% Methanol - (1µM PFOA + 1µM PFPA)	-0.5253296	0.0674381	21	-7.789804	5e-07
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA)	-0.5440525	0.0674381	21	-8.067435	3e-07

Caov-3 Mix ALA JC-1

Table 52 400uM treatment group

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - (1µM PFHpA + 1µM PFPA)	-0.6099976	0.082796	21	-7.367476	1.20e-06
1% Methanol - (1µM PFOA + 1µM PFHpA)	-0.4940302	0.082796	21	-5.966836	2.55e-05
1% Methanol - (1µM PFOA + 1µM PFPA)	-0.5913916	0.082796	21	-7.142756	1.90e-06
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA)	-0.6750944	0.082796	21	-8.153708	2.00e-07

Table 52 Treatment Group = 400µM

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - (1µM PFHpA + 1µM PFPA)	-0.6099976	0.082796	21	-7.367476	1.20e-06
1% Methanol - (1µM PFOA + 1µM PFHpA)	-0.4940302	0.082796	21	-5.966836	2.55e-05
1% Methanol - (1µM PFOA + 1µM PFPA)	-0.5913916	0.082796	21	-7.142756	1.90e-06
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA)	-0.6750944	0.082796	21	-8.153708	2.00e-07

Table 52 Treatment Group = PDP + 100µM

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - (1µM PFHpA + 1µM PFPA)	-0.3015471	0.0742104	21	-4.063406	0.0022316
1% Methanol - (1µM PFOA + 1µM PFHpA)	-0.4310190	0.0742104	21	-5.808065	0.0000366
1% Methanol - (1µM PFOA + 1µM PFPA)	-0.4315174	0.0742104	21	-5.814781	0.0000360
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA)	-0.4427627	0.0742104	21	-5.966313	0.0000255

Table 52 Treatment Group = PDP + 200µM

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - (1µM PFHpA + 1µM PFPA)	-0.3316460	0.0777582	21	-4.265091	0.0013781
1% Methanol - (1µM PFOA + 1µM PFHpA)	-0.4822974	0.0777582	21	-6.202525	0.0000150
1% Methanol - (1µM PFOA + 1µM PFPA)	-0.4283287	0.0777582	21	-5.508468	0.0000729
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA)	-0.3887056	0.0777582	21	-4.998899	0.0002404

Table 52 Treatment Group = PDP + 400µM

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - (1µM PFHpA + 1µM PFPA)	-0.3597916	0.0776556	21	-4.633169	0.0005724
1% Methanol - (1µM PFOA + 1µM PFHpA)	-0.4937849	0.0776556	21	-6.358650	0.0000106
1% Methanol - (1µM PFOA + 1µM PFPA)	-0.5053830	0.0776556	21	-6.508003	0.0000076
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA)	-0.4361607	0.0776556	21	-5.616601	0.0000568

OVCAR-3 PFAS BPD JC-1

Table 53 400uM treatment group

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFHpA	-0.9155740	0.0886555	31	-10.327319	0.0000000
1% Methanol - 2µM PFOA	-0.5579828	0.0886555	31	-6.293829	0.0000032
1% Methanol - 2µM PFPA	-0.7746547	0.0886555	31	-8.737804	0.0000000
1% Methanol - 500nM PFHpA	-0.6445543	0.0886555	31	-7.270322	0.0000002
1% Methanol - 500nM PFOA	-0.4474966	0.0886555	31	-5.047587	0.0001124
1% Methanol - 500nM PFPA	-0.4909077	0.0886555	31	-5.537248	0.0000276

Table 53 Treatment Group = 400µM

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFHpA	-0.9155740	0.0886555	31	-10.327319	0.0000000
1% Methanol - 2µM PFOA	-0.5579828	0.0886555	31	-6.293829	0.0000032
1% Methanol - 2µM PFPA	-0.7746547	0.0886555	31	-8.737804	0.0000000
1% Methanol - 500nM PFHpA	-0.6445543	0.0886555	31	-7.270322	0.0000002
1% Methanol - 500nM PFOA	-0.4474966	0.0886555	31	-5.047587	0.0001124
1% Methanol - 500nM PFPA	-0.4909077	0.0886555	31	-5.537248	0.0000276

Table 53 Treatment Group = PDP + 100µM

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFHpA	-0.2851126	0.0466659	31	-6.109657	0.0000054
1% Methanol - 2µM PFOA	-0.3069063	0.0466659	31	-6.576673	0.0000014
1% Methanol - 2µM PFPA	-0.4465916	0.0466659	31	-9.569978	0.0000000
1% Methanol - 500nM PFHpA	-0.2316692	0.0466659	31	-4.964423	0.0001427
1% Methanol - 500nM PFOA	-0.4059754	0.0466659	31	-8.699617	0.0000000
1% Methanol - 500nM PFPA	-0.3318783	0.0466659	31	-7.111796	0.0000003

Table 53 Treatment Group = PDP + 200µM

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFHpA	-0.2776478	0.0577503	31	-4.807729	0.0002234
1% Methanol - 2µM PFOA	-0.3028299	0.0577503	31	-5.243781	0.0000641
1% Methanol - 2µM PFPA	-0.3942378	0.0577503	31	-6.826593	0.0000007
1% Methanol - 500nM PFHpA	-0.2444346	0.0577503	31	-4.232612	0.0011431
1% Methanol - 500nM PFOA	-0.3463835	0.0577503	31	-5.997951	0.0000074
1% Methanol - 500nM PFPA	-0.3361536	0.0577503	31	-5.820811	0.0000123

Table 53 Treatment Group = PDP + 400µM

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFHpA	-0.2784078	0.0732479	31	-3.800900	0.0037935
1% Methanol - 2µM PFOA	-0.2959866	0.0732479	31	-4.040891	0.0019545
1% Methanol - 2µM PFPA	-0.3441461	0.0732479	31	-4.698378	0.0003053
1% Methanol - 500nM PFHpA	-0.3160480	0.0732479	31	-4.314774	0.0009070
1% Methanol - 500nM PFOA	-0.4098472	0.0732479	31	-5.595347	0.0000234
1% Methanol - 500nM PFPA	-0.4129932	0.0732479	31	-5.638297	0.0000207

OVCAR-3 PFAS ALA JC-1

Table 54 400uM treatment group

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFHpA	-0.7176165	0.1186566	31	-6.047844	0.0000064
1% Methanol - 2µM PFOA	-0.4926562	0.1186566	31	-4.151950	0.0014334
1% Methanol - 2µM PFPA	-0.6762168	0.1186566	31	-5.698941	0.0000174
1% Methanol - 500nM PFHpA	-0.6841064	0.1186566	31	-5.765432	0.0000144
1% Methanol - 500nM PFOA	-0.3122373	0.1186566	31	-2.631437	0.0762353
1% Methanol - 500nM PFPA	-0.4750633	0.1186566	31	-4.003683	0.0021675

Table 54 Treatment Group = 400µM

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFHpA	-0.7176165	0.1186566	31	-6.047844	0.0000064
1% Methanol - 2µM PFOA	-0.4926562	0.1186566	31	-4.151950	0.0014334
1% Methanol - 2µM PFPA	-0.6762168	0.1186566	31	-5.698941	0.0000174
1% Methanol - 500nM PFHpA	-0.6841064	0.1186566	31	-5.765432	0.0000144
1% Methanol - 500nM PFOA	-0.3122373	0.1186566	31	-2.631437	0.0762353
1% Methanol - 500nM PFPA	-0.4750633	0.1186566	31	-4.003683	0.0021675

Table 54 Treatment Group = PDP + 100µM

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFHpA	-0.4735964	0.0684719	31	-6.916656	0.0000006
1% Methanol - 2µM PFOA	-0.3357929	0.0684719	31	-4.904100	0.0001696
1% Methanol - 2µM PFPA	-0.3530069	0.0684719	31	-5.155502	0.0000825
1% Methanol - 500nM PFHpA	-0.4713851	0.0684719	31	-6.884362	0.0000006
1% Methanol - 500nM PFOA	-0.3497234	0.0684719	31	-5.107548	0.0000947
1% Methanol - 500nM PFPA	-0.3997381	0.0684719	31	-5.837990	0.0000117

Table 54 Treatment Group = PDP + 200µM

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFHpA	-0.4687432	0.0892941	31	-5.249433	0.0000630
1% Methanol - 2µM PFOA	-0.3485262	0.0892941	31	-3.903129	0.0028635
1% Methanol - 2µM PFPA	-0.4053562	0.0892941	31	-4.539565	0.0004799
1% Methanol - 500nM PFHpA	-0.6045376	0.0892941	31	-6.770188	0.0000008
1% Methanol - 500nM PFOA	-0.5138661	0.0892941	31	-5.754762	0.0000148
1% Methanol - 500nM PFPA	-0.3650756	0.0892941	31	-4.088464	0.0017118

Table 54 Treatment Group = PDP + 400µM

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - 2µM PFHpA	-0.5272902	0.0995787	31	-5.295212	0.0000553
1% Methanol - 2µM PFOA	-0.4512907	0.0995787	31	-4.532001	0.0004904
1% Methanol - 2µM PFPA	-0.5067247	0.0995787	31	-5.088686	0.0000999
1% Methanol - 500nM PFHpA	-0.4717553	0.0995787	31	-4.737514	0.0002731
1% Methanol - 500nM PFOA	-0.6917778	0.0995787	31	-6.947048	0.0000005
1% Methanol - 500nM PFPA	-0.3821338	0.0995787	31	-3.837507	0.0034309

OVCAR-3 Mix BPD JC-1

Table 55 400uM treatment group

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - (1µM PFHpA + 1µM PFPA)	-0.9449626	0.0804819	21	-11.741302	0e+00
1% Methanol - (1µM PFOA + 1µM PFHpA)	-0.6567263	0.0804819	21	-8.159923	2e-07
1% Methanol - (1µM PFOA + 1µM PFPA)	-0.7284315	0.0804819	21	-9.050870	0e+00
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA)	-1.2106571	0.0804819	21	-15.042596	0e+00

Table 55 Treatment Group = 400µM

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - (1µM PFHpA + 1µM PFPA)	-0.9449626	0.0804819	21	-11.741302	0e+00
1% Methanol - (1µM PFOA + 1µM PFHpA)	-0.6567263	0.0804819	21	-8.159923	2e-07
1% Methanol - (1µM PFOA + 1µM PFPA)	-0.7284315	0.0804819	21	-9.050870	0e+00
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA)	-1.2106571	0.0804819	21	-15.042596	0e+00

Table 55 Treatment Group = PDP + 100µM

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - (1µM PFHpA + 1µM PFPA)	-0.3309935	0.0372927	21	-8.875561	1e-07
1% Methanol - (1µM PFOA + 1µM PFHpA)	-0.4293835	0.0372927	21	-11.513877	0e+00
1% Methanol - (1µM PFOA + 1µM PFPA)	-0.2889809	0.0372927	21	-7.748995	5e-07
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA)	-0.3125458	0.0372927	21	-8.380888	2e-07

Table 55 Treatment Group = PDP + 200µM

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - (1µM PFHpA + 1µM PFPA)	-0.2987913	0.0438255	21	-6.817746	3.90e-06
1% Methanol - (1µM PFOA + 1µM PFHpA)	-0.4131135	0.0438255	21	-9.426322	0.00e+00
1% Methanol - (1µM PFOA + 1µM PFPA)	-0.2751544	0.0438255	21	-6.278405	1.26e-05
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA)	-0.2753294	0.0438255	21	-6.282400	1.25e-05

Table 55 Treatment Group = PDP + 400µM

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - (1µM PFHpA + 1µM PFPA)	-0.3734282	0.0653592	21	-5.713477	0.0000454
1% Methanol - (1µM PFOA + 1µM PFHpA)	-0.4731591	0.0653592	21	-7.239366	0.0000016
1% Methanol - (1µM PFOA + 1µM PFPA)	-0.3394706	0.0653592	21	-5.193924	0.0001519
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA)	-0.3051847	0.0653592	21	-4.669347	0.0005251

OVCAR-3 Mix ALA JC-1

Table 56 400uM treatment group

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - (1µM PFHpA + 1µM PFPA)	-0.6998142	0.1136408	21	-6.158123	0.0000166
1% Methanol - (1µM PFOA + 1µM PFHpA)	-0.2838985	0.1136408	21	-2.498209	0.0808609
1% Methanol - (1µM PFOA + 1µM PFPA)	-0.3917271	0.1136408	21	-3.447063	0.0096272
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA)	-0.6619982	0.1136408	21	-5.825355	0.0000352

Table 56 Treatment Group = 400µM

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - (1µM PFHpA + 1µM PFPA)	-0.6998142	0.1136408	21	-6.158123	0.0000166
1% Methanol - (1µM PFOA + 1µM PFHpA)	-0.2838985	0.1136408	21	-2.498209	0.0808609
1% Methanol - (1µM PFOA + 1µM PFPA)	-0.3917271	0.1136408	21	-3.447063	0.0096272
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA)	-0.6619982	0.1136408	21	-5.825355	0.0000352

Table 56 Treatment Group = PDP + 100µM

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - (1µM PFHpA + 1µM PFPA)	-0.5137679	0.150111	21	-3.422586	0.0101954
1% Methanol - (1µM PFOA + 1µM PFHpA)	-0.3100478	0.150111	21	-2.065457	0.1904250
1% Methanol - (1µM PFOA + 1µM PFPA)	-0.4639724	0.150111	21	-3.090862	0.0219701
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA)	-0.6829374	0.150111	21	-4.549549	0.0006986

Table 56 Treatment Group = PDP + 200µM

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - (1µM PFHpA + 1µM PFPA)	-0.4705920	0.0590511	21	-7.969229	0.0000004
1% Methanol - (1µM PFOA + 1µM PFHpA)	-0.2736606	0.0590511	21	-4.634299	0.0005708
1% Methanol - (1µM PFOA + 1µM PFPA)	-0.4344415	0.0590511	21	-7.357040	0.0000012
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA)	-0.4669811	0.0590511	21	-7.908080	0.0000004

Table 56 Treatment Group = PDP + 400µM

contrast	estimate	SE	df	t.ratio	p.value
1% Methanol - (1µM PFHpA + 1µM PFPA)	-0.4466244	0.0917383	21	-4.868464	0.0003272
1% Methanol - (1µM PFOA + 1µM PFHpA)	-0.5086775	0.0917383	21	-5.544879	0.0000670
1% Methanol - (1µM PFOA + 1µM PFPA)	-0.4197093	0.0917383	21	-4.575074	0.0006573
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA)	-0.4208610	0.0917383	21	-4.587628	0.0006380

Please compare BPD-PDP and ALA-PpIX-PDP + carboplatin groups for each PFAS to carboplatin only group

OVCAR-3 Carb PDP

Table 57 Exposure Group = 2µM PFHpA

contrast	estimate	SE	df	t.ratio	p.value
50µM Carboplatin - (BPD-PDP + 50µM Carboplatin)	0.4052271	0.1376831	11	2.943188	0.0133713

Table 57 Exposure Group = 2µM PFHpA

contrast	estimate	SE	df	t.ratio	p.value
400µM Carboplatin - (ALA-PDP + 400µM Carboplatin)	0.4038799	0.1994757	8	2.024707	0.0774908

Table 57 Exposure Group = 2µM PFPA

contrast	estimate	SE	df	t.ratio	p.value
50µM Carboplatin - (BPD-PDP + 50µM Carboplatin)	0.4052782	0.0538304	11	7.5288	1.16e-05

Table 57 Exposure Group = 2µM PFPA

contrast	estimate	SE	df	t.ratio	p.value
100µM Carboplatin - (ALA-PDP + 100µM Carboplatin)	0.5038754	0.1689585	16	2.982244	0.0175212
100µM Carboplatin - (BPD-PDP + 100µM Carboplatin)	0.4983276	0.1511210	16	3.297540	0.0090649

Table 57 Exposure Group = 2µM PFPA

contrast	estimate	SE	df	t.ratio	p.value
200µM Carboplatin - (ALA-PDP + 200µM Carboplatin)	0.5244204	0.0865916	16	6.056249	0.0000333
200µM Carboplatin - (BPD-PDP + 200µM Carboplatin)	0.2753666	0.0774499	16	3.555416	0.0052654

Table 57 Exposure Group = 500nM PFHpA

contrast	estimate	SE	df	t.ratio	p.value
400µM Carboplatin - (ALA-PDP + 400µM Carboplatin)	0.2393526	0.146566	8	1.633071	0.1410968

Table 57 Exposure Group = 1µM PFHpA + 1µM PFPA

contrast	estimate	SE	df	t.ratio	p.value
400µM Carboplatin - (ALA-PDP + 400µM Carboplatin)	0.2845795	0.0503722	16	5.649530	7.24e-05
400µM Carboplatin - (BPD-PDP + 400µM Carboplatin)	0.3303194	0.0503722	16	6.557568	1.32e-05

Caov-3 Carb PDP

Table 58 Exposure Group = 2µM PFPA

contrast	estimate	SE	df	t.ratio	p.value
400µM Carboplatin - (ALA-PDP + 400µM Carboplatin)	0.5157619	0.166463	14	3.098358	0.0156542
400µM Carboplatin - (BPD-PDP + 400µM Carboplatin)	0.4988214	0.166463	14	2.996591	0.0191401

Table 58 Exposure Group = 750nM PFOA + 750nM PFHpA + 750nM PFPA

contrast	estimate	SE	df	t.ratio	p.value
400µM Carboplatin - (ALA-PDP + 400µM Carboplatin)	0.2743366	0.0627527	16	4.371712	0.0009484
400µM Carboplatin - (BPD-PDP + 400µM Carboplatin)	0.3719735	0.0627527	16	5.927612	0.0000425