1. Gene Aliases

CDCA3, Cell Division Cycle Associated 3, TOME-1, GRCC8, Cell Division Cycle-Associated Protein 3, Trigger Of Mitotic Entry Protein 1, Gene-Rich Cluster Protein C8, TOME1, Trigger Of Mitotic Entry 1, C8

[https://www.genecards.org/cgi-bin/carddisp.pl?gene=CDCA3&keywords=CDCA3].

2. Association with Toxicity and/or Disease at a Transcriptional Level

3. Summary of Protein Family and Structure

4. Proteins Known to Interact with Gene Product

Interactions with experimental support

Interactions with text mining support

5. Links to Gene Databases

6. GO Terms, MSigDB Signatures, Pathways Containing Gene with Descriptions of Gene Sets

Pathways:

GO terms:

cell division [The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells.|Note that this term differs from 'cytokinesis ; GO:0000910' in that cytokinesis does not include nuclear division. GO:0051301]

protein ubiquitination [The process in which one or more ubiquitin groups are added to a protein. GO:0016567]

MSigDB Signatures:

BIOCARTA_CLASSIC_PATHWAY: Classical Complement Pathway [https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/BIOCARTA_CLASSIC_PATHWAY.html]

7. Gene Descriptions

8. Cellular Location of Gene Product

Localized to the cytosol. Predicted location: Intracellular [https://www.proteinatlas.org/ENSG00000111665/subcellular]

9. Mechanistic Information

Summary

The upregulation of C8, specifically CDCA3, in response to lung diseases can be viewed as a cellular adaptation to heightened demands for tissue repair and regeneration [CS: 7]. In a healthy lung exposed to minor injuries or infections, an increase in cell division facilitated by CDCA3 would aid in the rapid repair of damaged tissue, ensuring the maintenance of lung function and integrity [CS: 6]. This increased mitotic activity, driven by CDCA3's role in promoting the transition from the G2 phase to mitosis, would be a crucial response to restore normal lung architecture and function after injury or infection [CS: 7].

In the context of lung diseases like NSCLC, however, this adaptive response becomes maladaptive [CS: 6]. CDCA3 is highly increased in NSCLC compared to nonmalignant tissue, and its overexpression is associated with worse patient prognosis [CS: 8]. This overexpression may be a response to the cellular need for increased mitosis in the rapidly dividing cancer cells [CS: 5]. CDCA3, by participating in E3 ligase complexes, mediates the ubiquitination and degradation of WEE1 kinase at the G2/M phase, thereby promoting cell division [CS: 7].

10. Upstream Regulators

11. Tissues/Cell Type Where Genes are Overexpressed

12. Role of Gene in Other Tissues

13. Chemicals Known to Elicit Transcriptional Response of Biomarker in Tissue of Interest

Compounds that increase expression of the gene:

Compounds that decrease expression of the gene:

14. DisGeNet Biomarker Associations to Disease in Organ of Interest

No biomarkers associated with disease or organ of interest were found