1. Gene Aliases

2. Association with Toxicity and/or Disease at a Transcriptional Level

No relevant information pertaining to this subject matter was identified in the existing body of literature.

3. Summary of Protein Family and Structure

4. Proteins Known to Interact with Gene Product

Interactions with experimental support

5. Links to Gene Databases

6. GO Terms, MSigDB Signatures, Pathways Containing Gene with Descriptions of Gene Sets

Pathways:

GO terms:

Gene Slc66a3 lacks GO biological process annotations [https://rgd.mcw.edu/rgdweb/report/gene/main.html?id=1306818#geneOntologyAnnotationsCurator]

MSigDB Signatures:

CHICAS_RB1_TARGETS_CONFLUENT: Genes up-regulated in confluent IMR90 cells (fibroblast) after knockdown of RB1 [GeneID=5925] by RNAi. [https://www.gsea-msigdb.org/gsea/msigdb/human/geneset/CHICAS_RB1_TARGETS_CONFLUENT.html]
[PMID: 23560115], [https://reactome.org/content/detail/R-HSA-422356]

7. Gene Descriptions

NCBI Gene Summary: Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

GeneCards Summary: SLC66A3 (Solute Carrier Family 66 Member 3) is a Protein Coding gene. An important paralog of this gene is MPDU1.

8. Cellular Location of Gene Product

Localized to the cytosol. Predicted location: Membrane [https://www.proteinatlas.org/ENSG00000162976/subcellular]

9. Mechanistic Information

Summary

SLC66A3 is a protein-coding gene with expression responsiveness to specific nutrient signals as evident from its marked upregulation in murine pancreatic beta-cell lines exposed to high glucose conditions [CS: 5]. Although its precise biological function remains undetermined [CS: 10], the gene belongs to the SLC66 family of lysosomal amino acid transporters, suggesting a probable role in intracellular amino acid transport within lysosomes [CS: 8]. In the context of liver-associated diseases and toxicities, SLC66A3 could hypothetically be involved in cellular adaptation to fluctuating nutrient levels, a condition the liver frequently encounters, however with a lack of supporting information these conclusions will be speculative [CS: 3].

10. Upstream Regulators

11. Tissues/Cell Type Where Genes are Overexpressed

Tissue type enchanced: low tissue specificity [https://www.proteinatlas.org/ENSG00000162976/tissue]

Cell type enchanced: langerhans cells (cell type enhanced) [https://www.proteinatlas.org/ENSG00000162976/single+cell+type]

12. Role of Gene in Other Tissues

13. Chemicals Known to Elicit Transcriptional Response of Biomarker in Tissue of Interest

Compounds that increase expression of the gene:

Compounds that decrease expression of the gene:

14. DisGeNet Biomarker Associations to Disease in Organ of Interest

No DisGenNet altered expression associations were found for Slc66a3 and diseases associated with Liver