If this is the first time you are viewing this file, please choose 'Save As' from the 'File' menu
and resave this file as an Excel file type. This will greatly speed up future viewings of this file.
Short-Term Individual Animal Non Neoplastic Diagnosis
Study Information:
Chemical Name: | Perfluorononanoic Acid |
CASRN: | ="375-95-1" |
Study Number: | C04049 |
Exposure Route: | GAVAGE |
TDMS Number: | 0404901 |
Sex: | Female |
Strain and Species: | HSD Rats |
Female Individual Animal Non Neoplastic Diagnoses
System |
Organ |
Site |
Treatment Group |
Number Examined |
Cage Number |
Animal Number |
Days on Study |
Lesion Found |
Lesion Name |
Lesion Qualifier |
Removal Reason |
Alimentary System |
Liver |
Hepatocyte |
1.56 mg/kg |
10 |
127 |
772 |
29 |
1 |
Cytoplasmic Alteration |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
1.56 mg/kg |
10 |
127 |
774 |
29 |
1 |
Cytoplasmic Alteration |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
1.56 mg/kg |
10 |
128 |
778 |
29 |
1 |
Cytoplasmic Alteration |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
1.56 mg/kg |
10 |
128 |
779 |
29 |
1 |
Cytoplasmic Alteration |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
1.56 mg/kg |
10 |
128 |
780 |
29 |
1 |
Cytoplasmic Alteration |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
3.12 mg/kg |
10 |
129 |
781 |
29 |
1 |
Cytoplasmic Alteration |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
3.12 mg/kg |
10 |
129 |
782 |
29 |
1 |
Cytoplasmic Alteration |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
3.12 mg/kg |
10 |
129 |
783 |
29 |
1 |
Cytoplasmic Alteration |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
3.12 mg/kg |
10 |
129 |
784 |
29 |
1 |
Cytoplasmic Alteration |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
3.12 mg/kg |
10 |
129 |
785 |
29 |
1 |
Cytoplasmic Alteration |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
3.12 mg/kg |
10 |
130 |
786 |
29 |
1 |
Cytoplasmic Alteration |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
3.12 mg/kg |
10 |
130 |
787 |
29 |
1 |
Cytoplasmic Alteration |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
3.12 mg/kg |
10 |
130 |
788 |
29 |
1 |
Cytoplasmic Alteration |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
3.12 mg/kg |
10 |
130 |
789 |
29 |
1 |
Cytoplasmic Alteration |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
3.12 mg/kg |
10 |
130 |
790 |
29 |
1 |
Cytoplasmic Alteration |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
6.25 mg/kg |
10 |
131 |
791 |
29 |
1 |
Cytoplasmic Alteration |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
6.25 mg/kg |
10 |
131 |
792 |
29 |
1 |
Cytoplasmic Alteration |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
6.25 mg/kg |
10 |
131 |
793 |
29 |
1 |
Cytoplasmic Alteration |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
6.25 mg/kg |
10 |
131 |
794 |
29 |
1 |
Cytoplasmic Alteration |
Marked |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
6.25 mg/kg |
10 |
131 |
795 |
29 |
1 |
Cytoplasmic Alteration |
Moderate |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
6.25 mg/kg |
10 |
132 |
796 |
29 |
1 |
Cytoplasmic Alteration |
Moderate |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
6.25 mg/kg |
10 |
132 |
797 |
29 |
1 |
Cytoplasmic Alteration |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
6.25 mg/kg |
10 |
132 |
798 |
29 |
1 |
Cytoplasmic Alteration |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
6.25 mg/kg |
10 |
132 |
799 |
29 |
1 |
Cytoplasmic Alteration |
Moderate |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
6.25 mg/kg |
10 |
132 |
800 |
29 |
1 |
Cytoplasmic Alteration |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
12.5 mg/kg |
10 |
133 |
801 |
15 |
1 |
Cytoplasmic Alteration |
Minimal |
Natural Death |
Alimentary System |
Liver |
Hepatocyte |
12.5 mg/kg |
10 |
133 |
802 |
15 |
1 |
Cytoplasmic Alteration |
Minimal |
Natural Death |
Alimentary System |
Liver |
Hepatocyte |
12.5 mg/kg |
10 |
133 |
803 |
15 |
1 |
Cytoplasmic Alteration |
Minimal |
Natural Death |
Alimentary System |
Liver |
Hepatocyte |
12.5 mg/kg |
10 |
133 |
805 |
13 |
1 |
Cytoplasmic Alteration |
Minimal |
Natural Death |
Alimentary System |
Liver |
Hepatocyte |
12.5 mg/kg |
10 |
134 |
806 |
27 |
1 |
Cytoplasmic Alteration |
Minimal |
Natural Death |
Alimentary System |
Liver |
Hepatocyte |
12.5 mg/kg |
10 |
134 |
808 |
16 |
1 |
Cytoplasmic Alteration |
Mild |
Natural Death |
Alimentary System |
Liver |
Hepatocyte |
12.5 mg/kg |
10 |
134 |
809 |
25 |
1 |
Cytoplasmic Alteration |
Minimal |
Natural Death |
Alimentary System |
Liver |
Hepatocyte |
12.5 mg/kg |
10 |
134 |
810 |
27 |
1 |
Cytoplasmic Alteration |
Mild |
Natural Death |
Alimentary System |
Liver |
Hepatocyte |
12.5 mg/kg |
10 |
134 |
807 |
29 |
1 |
Cytoplasmic Alteration |
Marked |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
3.12 mg/kg |
10 |
130 |
788 |
29 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
3.12 mg/kg |
10 |
130 |
789 |
29 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
6.25 mg/kg |
10 |
131 |
791 |
29 |
1 |
Hypertrophy |
Marked |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
6.25 mg/kg |
10 |
131 |
792 |
29 |
1 |
Hypertrophy |
Marked |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
6.25 mg/kg |
10 |
131 |
793 |
29 |
1 |
Hypertrophy |
Marked |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
6.25 mg/kg |
10 |
131 |
794 |
29 |
1 |
Hypertrophy |
Marked |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
6.25 mg/kg |
10 |
131 |
795 |
29 |
1 |
Hypertrophy |
Marked |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
6.25 mg/kg |
10 |
132 |
796 |
29 |
1 |
Hypertrophy |
Marked |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
6.25 mg/kg |
10 |
132 |
797 |
29 |
1 |
Hypertrophy |
Marked |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
6.25 mg/kg |
10 |
132 |
798 |
29 |
1 |
Hypertrophy |
Marked |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
6.25 mg/kg |
10 |
132 |
799 |
29 |
1 |
Hypertrophy |
Marked |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
6.25 mg/kg |
10 |
132 |
800 |
29 |
1 |
Hypertrophy |
Marked |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
12.5 mg/kg |
10 |
133 |
801 |
15 |
1 |
Hypertrophy |
Moderate |
Natural Death |
Alimentary System |
Liver |
Hepatocyte |
12.5 mg/kg |
10 |
133 |
802 |
15 |
1 |
Hypertrophy |
Moderate |
Natural Death |
Alimentary System |
Liver |
Hepatocyte |
12.5 mg/kg |
10 |
133 |
803 |
15 |
1 |
Hypertrophy |
Moderate |
Natural Death |
Alimentary System |
Liver |
Hepatocyte |
12.5 mg/kg |
10 |
133 |
804 |
17 |
1 |
Hypertrophy |
Moderate |
Natural Death |
Alimentary System |
Liver |
Hepatocyte |
12.5 mg/kg |
10 |
133 |
805 |
13 |
1 |
Hypertrophy |
Mild |
Natural Death |
Alimentary System |
Liver |
Hepatocyte |
12.5 mg/kg |
10 |
134 |
806 |
27 |
1 |
Hypertrophy |
Mild |
Natural Death |
Alimentary System |
Liver |
Hepatocyte |
12.5 mg/kg |
10 |
134 |
808 |
16 |
1 |
Hypertrophy |
Moderate |
Natural Death |
Alimentary System |
Liver |
Hepatocyte |
12.5 mg/kg |
10 |
134 |
809 |
25 |
1 |
Hypertrophy |
Moderate |
Natural Death |
Alimentary System |
Liver |
Hepatocyte |
12.5 mg/kg |
10 |
134 |
810 |
27 |
1 |
Hypertrophy |
Marked |
Natural Death |
Alimentary System |
Liver |
Hepatocyte |
12.5 mg/kg |
10 |
134 |
807 |
29 |
1 |
Hypertrophy |
Marked |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
25 mg/kg |
10 |
135 |
811 |
12 |
1 |
Hypertrophy |
Moderate |
Natural Death |
Alimentary System |
Liver |
Hepatocyte |
25 mg/kg |
10 |
135 |
812 |
12 |
1 |
Hypertrophy |
Mild |
Natural Death |
Alimentary System |
Liver |
Hepatocyte |
25 mg/kg |
10 |
135 |
813 |
12 |
1 |
Hypertrophy |
Moderate |
Natural Death |
Alimentary System |
Liver |
Hepatocyte |
25 mg/kg |
10 |
135 |
814 |
11 |
1 |
Hypertrophy |
Moderate |
Natural Death |
Alimentary System |
Liver |
Hepatocyte |
25 mg/kg |
10 |
135 |
815 |
12 |
1 |
Hypertrophy |
Moderate |
Natural Death |
Alimentary System |
Liver |
Hepatocyte |
25 mg/kg |
10 |
136 |
816 |
12 |
1 |
Hypertrophy |
Mild |
Natural Death |
Alimentary System |
Liver |
Hepatocyte |
25 mg/kg |
10 |
136 |
817 |
15 |
1 |
Hypertrophy |
Moderate |
Natural Death |
Alimentary System |
Liver |
Hepatocyte |
25 mg/kg |
10 |
136 |
818 |
12 |
1 |
Hypertrophy |
Moderate |
Natural Death |
Alimentary System |
Liver |
Hepatocyte |
25 mg/kg |
10 |
136 |
819 |
12 |
1 |
Hypertrophy |
Mild |
Natural Death |
Alimentary System |
Liver |
Hepatocyte |
25 mg/kg |
10 |
136 |
820 |
14 |
1 |
Hypertrophy |
Mild |
Natural Death |
Alimentary System |
Liver |
Hepatocyte |
12.5 mg/kg |
10 |
134 |
806 |
27 |
1 |
Necrosis |
Minimal |
Natural Death |
Alimentary System |
Liver |
Hepatocyte |
12.5 mg/kg |
10 |
134 |
808 |
16 |
1 |
Necrosis |
Minimal |
Natural Death |
Alimentary System |
Liver |
Hepatocyte |
12.5 mg/kg |
10 |
134 |
809 |
25 |
1 |
Necrosis |
Minimal |
Natural Death |
Alimentary System |
Liver |
Hepatocyte |
12.5 mg/kg |
10 |
134 |
810 |
27 |
1 |
Necrosis |
Mild |
Natural Death |
Alimentary System |
Liver |
Hepatocyte |
25 mg/kg |
10 |
135 |
811 |
12 |
1 |
Necrosis |
Minimal |
Natural Death |
Alimentary System |
Liver |
Hepatocyte |
25 mg/kg |
10 |
135 |
813 |
12 |
1 |
Necrosis |
Minimal |
Natural Death |
Alimentary System |
Liver |
Hepatocyte |
25 mg/kg |
10 |
136 |
816 |
12 |
1 |
Necrosis |
Minimal |
Natural Death |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
126 |
770 |
29 |
1 |
Clear Cell Focus |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
125 |
763 |
29 |
1 |
Infiltration Cellular |
Minimal, Mixed Cell |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
126 |
770 |
29 |
1 |
Infiltration Cellular |
Minimal, Mixed Cell |
Terminal Sacrifice |
Alimentary System |
Liver |
|
6.25 mg/kg |
10 |
131 |
792 |
29 |
1 |
Infiltration Cellular |
Minimal, Mixed Cell |
Terminal Sacrifice |
Alimentary System |
Stomach, Forestomach |
Epithelium |
12.5 mg/kg |
10 |
133 |
802 |
15 |
1 |
Hyperplasia |
Mild |
Natural Death |
Alimentary System |
Stomach, Forestomach |
Epithelium |
12.5 mg/kg |
10 |
133 |
803 |
15 |
1 |
Hyperplasia |
Moderate |
Natural Death |
Alimentary System |
Stomach, Forestomach |
Epithelium |
12.5 mg/kg |
10 |
133 |
804 |
17 |
1 |
Hyperplasia |
Mild |
Natural Death |
Alimentary System |
Stomach, Forestomach |
Epithelium |
12.5 mg/kg |
10 |
133 |
805 |
13 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Alimentary System |
Stomach, Forestomach |
Epithelium |
12.5 mg/kg |
10 |
134 |
806 |
27 |
1 |
Hyperplasia |
Moderate |
Natural Death |
Alimentary System |
Stomach, Forestomach |
Epithelium |
12.5 mg/kg |
10 |
134 |
808 |
16 |
1 |
Hyperplasia |
Mild |
Natural Death |
Alimentary System |
Stomach, Forestomach |
Epithelium |
12.5 mg/kg |
10 |
134 |
810 |
27 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Alimentary System |
Stomach, Forestomach |
Epithelium |
25 mg/kg |
10 |
135 |
811 |
12 |
1 |
Hyperplasia |
Mild |
Natural Death |
Alimentary System |
Stomach, Forestomach |
Epithelium |
25 mg/kg |
10 |
135 |
812 |
12 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Alimentary System |
Stomach, Forestomach |
Epithelium |
25 mg/kg |
10 |
135 |
813 |
12 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Alimentary System |
Stomach, Forestomach |
Epithelium |
25 mg/kg |
10 |
135 |
814 |
11 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Alimentary System |
Stomach, Forestomach |
Epithelium |
25 mg/kg |
10 |
136 |
816 |
12 |
1 |
Hyperplasia |
Mild |
Natural Death |
Alimentary System |
Stomach, Forestomach |
Epithelium |
25 mg/kg |
10 |
136 |
819 |
12 |
1 |
Hyperplasia |
Mild |
Natural Death |
Alimentary System |
Stomach, Forestomach |
|
25 mg/kg |
10 |
135 |
815 |
12 |
1 |
Inflammation |
Minimal, Chronic Active |
Natural Death |
Genital System |
Uterus |
Bilateral |
Vehicle Control |
10 |
126 |
766 |
29 |
1 |
Dilation |
Moderate |
Terminal Sacrifice |
Hematopoietic System |
Bone Marrow |
|
12.5 mg/kg |
10 |
133 |
801 |
15 |
1 |
Hypocellularity |
Marked |
Natural Death |
Hematopoietic System |
Bone Marrow |
|
12.5 mg/kg |
10 |
133 |
802 |
15 |
1 |
Hypocellularity |
Marked |
Natural Death |
Hematopoietic System |
Bone Marrow |
|
12.5 mg/kg |
10 |
133 |
803 |
15 |
1 |
Hypocellularity |
Marked |
Natural Death |
Hematopoietic System |
Bone Marrow |
|
12.5 mg/kg |
10 |
133 |
804 |
17 |
1 |
Hypocellularity |
Marked |
Natural Death |
Hematopoietic System |
Bone Marrow |
|
12.5 mg/kg |
10 |
133 |
805 |
13 |
1 |
Hypocellularity |
Marked |
Natural Death |
Hematopoietic System |
Bone Marrow |
|
12.5 mg/kg |
10 |
134 |
806 |
27 |
1 |
Hypocellularity |
Marked |
Natural Death |
Hematopoietic System |
Bone Marrow |
|
12.5 mg/kg |
10 |
134 |
808 |
16 |
1 |
Hypocellularity |
Marked |
Natural Death |
Hematopoietic System |
Bone Marrow |
|
12.5 mg/kg |
10 |
134 |
809 |
25 |
1 |
Hypocellularity |
Marked |
Natural Death |
Hematopoietic System |
Bone Marrow |
|
12.5 mg/kg |
10 |
134 |
810 |
27 |
1 |
Hypocellularity |
Marked |
Natural Death |
Hematopoietic System |
Bone Marrow |
|
12.5 mg/kg |
10 |
134 |
807 |
29 |
1 |
Hypocellularity |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Bone Marrow |
|
25 mg/kg |
10 |
135 |
811 |
12 |
1 |
Hypocellularity |
Moderate |
Natural Death |
Hematopoietic System |
Bone Marrow |
|
25 mg/kg |
10 |
135 |
812 |
12 |
1 |
Hypocellularity |
Moderate |
Natural Death |
Hematopoietic System |
Bone Marrow |
|
25 mg/kg |
10 |
135 |
813 |
12 |
1 |
Hypocellularity |
Moderate |
Natural Death |
Hematopoietic System |
Bone Marrow |
|
25 mg/kg |
10 |
135 |
814 |
11 |
1 |
Hypocellularity |
Moderate |
Natural Death |
Hematopoietic System |
Bone Marrow |
|
25 mg/kg |
10 |
135 |
815 |
12 |
1 |
Hypocellularity |
Moderate |
Natural Death |
Hematopoietic System |
Bone Marrow |
|
25 mg/kg |
10 |
136 |
816 |
12 |
1 |
Hypocellularity |
Moderate |
Natural Death |
Hematopoietic System |
Bone Marrow |
|
25 mg/kg |
10 |
136 |
817 |
15 |
1 |
Hypocellularity |
Moderate |
Natural Death |
Hematopoietic System |
Bone Marrow |
|
25 mg/kg |
10 |
136 |
818 |
12 |
1 |
Hypocellularity |
Moderate |
Natural Death |
Hematopoietic System |
Bone Marrow |
|
25 mg/kg |
10 |
136 |
819 |
12 |
1 |
Hypocellularity |
Marked |
Natural Death |
Hematopoietic System |
Bone Marrow |
|
25 mg/kg |
10 |
136 |
820 |
14 |
1 |
Hypocellularity |
Moderate |
Natural Death |
Hematopoietic System |
Lymph Node |
Mandibular |
12.5 mg/kg |
10 |
133 |
801 |
15 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Lymph Node |
Mandibular |
12.5 mg/kg |
10 |
133 |
802 |
15 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Lymph Node |
Mandibular |
12.5 mg/kg |
10 |
133 |
805 |
13 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Lymph Node |
Mandibular |
12.5 mg/kg |
10 |
134 |
806 |
27 |
1 |
Atrophy |
Mild |
Natural Death |
Hematopoietic System |
Lymph Node |
Mandibular |
12.5 mg/kg |
10 |
134 |
808 |
16 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Lymph Node |
Mandibular |
12.5 mg/kg |
10 |
134 |
809 |
25 |
1 |
Atrophy |
Moderate |
Natural Death |
Hematopoietic System |
Lymph Node |
Mandibular |
12.5 mg/kg |
10 |
134 |
810 |
27 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Lymph Node |
Mandibular |
12.5 mg/kg |
10 |
134 |
807 |
29 |
1 |
Atrophy |
Mild |
Terminal Sacrifice |
Hematopoietic System |
Lymph Node |
Mandibular |
25 mg/kg |
10 |
135 |
811 |
12 |
1 |
Atrophy |
Moderate |
Natural Death |
Hematopoietic System |
Lymph Node |
Mandibular |
25 mg/kg |
10 |
135 |
812 |
12 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Lymph Node |
Mandibular |
25 mg/kg |
10 |
135 |
813 |
12 |
1 |
Atrophy |
Mild |
Natural Death |
Hematopoietic System |
Lymph Node |
Mandibular |
25 mg/kg |
10 |
135 |
814 |
11 |
1 |
Atrophy |
Moderate |
Natural Death |
Hematopoietic System |
Lymph Node |
Mandibular |
25 mg/kg |
10 |
135 |
815 |
12 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Lymph Node |
Mandibular |
25 mg/kg |
10 |
136 |
816 |
12 |
1 |
Atrophy |
Moderate |
Natural Death |
Hematopoietic System |
Lymph Node |
Mandibular |
25 mg/kg |
10 |
136 |
817 |
15 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Lymph Node |
Mandibular |
25 mg/kg |
10 |
136 |
818 |
12 |
1 |
Atrophy |
Mild |
Natural Death |
Hematopoietic System |
Lymph Node |
Mandibular |
25 mg/kg |
10 |
136 |
819 |
12 |
1 |
Atrophy |
Moderate |
Natural Death |
Hematopoietic System |
Lymph Node |
Mesenteric |
12.5 mg/kg |
10 |
133 |
802 |
15 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Lymph Node |
Mesenteric |
12.5 mg/kg |
10 |
133 |
803 |
15 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Lymph Node |
Mesenteric |
12.5 mg/kg |
10 |
133 |
804 |
17 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Lymph Node |
Mesenteric |
12.5 mg/kg |
10 |
133 |
805 |
13 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Lymph Node |
Mesenteric |
12.5 mg/kg |
10 |
134 |
806 |
27 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Lymph Node |
Mesenteric |
12.5 mg/kg |
10 |
134 |
808 |
16 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Lymph Node |
Mesenteric |
12.5 mg/kg |
10 |
134 |
809 |
25 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Lymph Node |
Mesenteric |
12.5 mg/kg |
10 |
134 |
810 |
27 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Lymph Node |
Mesenteric |
25 mg/kg |
10 |
135 |
811 |
12 |
1 |
Atrophy |
Moderate |
Natural Death |
Hematopoietic System |
Lymph Node |
Mesenteric |
25 mg/kg |
10 |
135 |
812 |
12 |
1 |
Atrophy |
Moderate |
Natural Death |
Hematopoietic System |
Lymph Node |
Mesenteric |
25 mg/kg |
10 |
135 |
813 |
12 |
1 |
Atrophy |
Moderate |
Natural Death |
Hematopoietic System |
Lymph Node |
Mesenteric |
25 mg/kg |
10 |
135 |
814 |
11 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Lymph Node |
Mesenteric |
25 mg/kg |
10 |
136 |
816 |
12 |
1 |
Atrophy |
Mild |
Natural Death |
Hematopoietic System |
Lymph Node |
Mesenteric |
25 mg/kg |
10 |
136 |
817 |
15 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Lymph Node |
Mesenteric |
25 mg/kg |
10 |
136 |
818 |
12 |
1 |
Atrophy |
Mild |
Natural Death |
Hematopoietic System |
Lymph Node |
Mesenteric |
25 mg/kg |
10 |
136 |
819 |
12 |
1 |
Atrophy |
Mild |
Natural Death |
Hematopoietic System |
Lymph Node |
Mesenteric |
25 mg/kg |
10 |
136 |
820 |
14 |
1 |
Atrophy |
Moderate |
Natural Death |
Hematopoietic System |
Spleen |
|
12.5 mg/kg |
10 |
133 |
801 |
15 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Spleen |
|
12.5 mg/kg |
10 |
133 |
802 |
15 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Spleen |
|
12.5 mg/kg |
10 |
133 |
803 |
15 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Spleen |
|
12.5 mg/kg |
10 |
133 |
804 |
17 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Spleen |
|
12.5 mg/kg |
10 |
134 |
806 |
27 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Spleen |
|
12.5 mg/kg |
10 |
134 |
808 |
16 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Spleen |
|
12.5 mg/kg |
10 |
134 |
809 |
25 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Spleen |
|
12.5 mg/kg |
10 |
134 |
810 |
27 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Spleen |
|
25 mg/kg |
10 |
135 |
811 |
12 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Spleen |
|
25 mg/kg |
10 |
135 |
812 |
12 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Spleen |
|
25 mg/kg |
10 |
135 |
813 |
12 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Spleen |
|
25 mg/kg |
10 |
135 |
814 |
11 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Spleen |
|
25 mg/kg |
10 |
135 |
815 |
12 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Spleen |
|
25 mg/kg |
10 |
136 |
816 |
12 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Spleen |
|
25 mg/kg |
10 |
136 |
817 |
15 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Spleen |
|
25 mg/kg |
10 |
136 |
818 |
12 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Spleen |
|
25 mg/kg |
10 |
136 |
819 |
12 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Spleen |
|
25 mg/kg |
10 |
136 |
820 |
14 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Thymus |
|
12.5 mg/kg |
10 |
133 |
801 |
15 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Thymus |
|
12.5 mg/kg |
10 |
133 |
802 |
15 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Thymus |
|
12.5 mg/kg |
10 |
133 |
803 |
15 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Thymus |
|
12.5 mg/kg |
10 |
133 |
804 |
17 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Thymus |
|
12.5 mg/kg |
10 |
133 |
805 |
13 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Thymus |
|
12.5 mg/kg |
10 |
134 |
806 |
27 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Thymus |
|
12.5 mg/kg |
10 |
134 |
808 |
16 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Thymus |
|
12.5 mg/kg |
10 |
134 |
809 |
25 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Thymus |
|
12.5 mg/kg |
10 |
134 |
810 |
27 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Thymus |
|
25 mg/kg |
10 |
135 |
811 |
12 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Thymus |
|
25 mg/kg |
10 |
135 |
812 |
12 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Thymus |
|
25 mg/kg |
10 |
135 |
813 |
12 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Thymus |
|
25 mg/kg |
10 |
135 |
814 |
11 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Thymus |
|
25 mg/kg |
10 |
135 |
815 |
12 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Thymus |
|
25 mg/kg |
10 |
136 |
816 |
12 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Thymus |
|
25 mg/kg |
10 |
136 |
817 |
15 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Thymus |
|
25 mg/kg |
10 |
136 |
818 |
12 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Thymus |
|
25 mg/kg |
10 |
136 |
819 |
12 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Thymus |
|
25 mg/kg |
10 |
136 |
820 |
14 |
1 |
Atrophy |
Marked |
Natural Death |
Respiratory System |
Lung |
Arteriole |
25 mg/kg |
10 |
136 |
817 |
15 |
1 |
Thrombus |
Minimal, Focal |
Natural Death |
Respiratory System |
Lung |
Vein |
12.5 mg/kg |
10 |
134 |
809 |
25 |
1 |
Thrombus |
Mild |
Natural Death |
Respiratory System |
Lung |
|
Vehicle Control |
10 |
126 |
768 |
29 |
1 |
Infiltration Cellular |
Minimal, Mixed Cell |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
25 mg/kg |
10 |
135 |
812 |
12 |
1 |
Degeneration |
Mild |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
25 mg/kg |
10 |
135 |
813 |
12 |
1 |
Degeneration |
Minimal |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
25 mg/kg |
10 |
136 |
816 |
12 |
1 |
Degeneration |
Minimal |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
25 mg/kg |
10 |
136 |
817 |
15 |
1 |
Degeneration |
Marked |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
25 mg/kg |
10 |
136 |
819 |
12 |
1 |
Degeneration |
Mild |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
25 mg/kg |
10 |
135 |
812 |
12 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
25 mg/kg |
10 |
135 |
812 |
12 |
1 |
Inflammation |
Moderate, Suppurative |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
25 mg/kg |
10 |
136 |
816 |
12 |
1 |
Inflammation |
Minimal, Suppurative |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
25 mg/kg |
10 |
136 |
817 |
15 |
1 |
Inflammation |
Minimal, Suppurative |
Natural Death |
Urinary System |
Kidney |
|
25 mg/kg |
10 |
136 |
817 |
15 |
1 |
Cyst |
Focal |
Natural Death |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
125 |
763 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
125 |
764 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
125 |
765 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
126 |
766 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
126 |
767 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
126 |
768 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
1.56 mg/kg |
10 |
127 |
775 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
1.56 mg/kg |
10 |
128 |
779 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
1.56 mg/kg |
10 |
128 |
780 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
3.12 mg/kg |
10 |
129 |
781 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
3.12 mg/kg |
10 |
129 |
783 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
3.12 mg/kg |
10 |
129 |
785 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
3.12 mg/kg |
10 |
130 |
786 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
3.12 mg/kg |
10 |
130 |
788 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
6.25 mg/kg |
10 |
131 |
793 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
6.25 mg/kg |
10 |
131 |
794 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
6.25 mg/kg |
10 |
131 |
795 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
12.5 mg/kg |
10 |
134 |
807 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
25 mg/kg |
10 |
135 |
811 |
12 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Natural Death |
Urinary System |
Kidney |
|
25 mg/kg |
10 |
135 |
812 |
12 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Natural Death |
Urinary System |
Kidney |
|
25 mg/kg |
10 |
135 |
814 |
11 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Natural Death |