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Short-Term Individual Animal Non Neoplastic Diagnosis
Study Information:
Chemical Name: | Wyeth 14,643 (WY) |
CASRN: | ="50892-23-4" |
Study Number: | C91069 |
Exposure Route: | GAVAGE |
TDMS Number: | 9106901 |
Sex: | Male |
Strain and Species: | HSD Rats |
Male Individual Animal Non Neoplastic Diagnoses
System |
Organ |
Site |
Treatment Group |
Number Examined |
Cage Number |
Animal Number |
Days on Study |
Lesion Found |
Lesion Name |
Lesion Qualifier |
Removal Reason |
Alimentary System |
Liver |
Hepatocyte |
6.25 mg/kg |
10 |
75 |
462 |
29 |
1 |
Cytoplasmic Alteration |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
6.25 mg/kg |
10 |
75 |
463 |
29 |
1 |
Cytoplasmic Alteration |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
6.25 mg/kg |
10 |
75 |
464 |
29 |
1 |
Cytoplasmic Alteration |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
6.25 mg/kg |
10 |
75 |
465 |
29 |
1 |
Cytoplasmic Alteration |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
6.25 mg/kg |
10 |
76 |
466 |
29 |
1 |
Cytoplasmic Alteration |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
6.25 mg/kg |
10 |
76 |
467 |
29 |
1 |
Cytoplasmic Alteration |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
6.25 mg/kg |
10 |
76 |
468 |
29 |
1 |
Cytoplasmic Alteration |
Moderate |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
6.25 mg/kg |
10 |
76 |
469 |
29 |
1 |
Cytoplasmic Alteration |
Moderate |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
6.25 mg/kg |
10 |
76 |
470 |
29 |
1 |
Cytoplasmic Alteration |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
12.5 mg/kg |
10 |
77 |
471 |
29 |
1 |
Cytoplasmic Alteration |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
12.5 mg/kg |
10 |
77 |
472 |
29 |
1 |
Cytoplasmic Alteration |
Moderate |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
12.5 mg/kg |
10 |
77 |
473 |
29 |
1 |
Cytoplasmic Alteration |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
12.5 mg/kg |
10 |
77 |
474 |
29 |
1 |
Cytoplasmic Alteration |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
12.5 mg/kg |
10 |
77 |
475 |
29 |
1 |
Cytoplasmic Alteration |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
12.5 mg/kg |
10 |
78 |
476 |
29 |
1 |
Cytoplasmic Alteration |
Moderate |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
12.5 mg/kg |
10 |
78 |
477 |
29 |
1 |
Cytoplasmic Alteration |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
12.5 mg/kg |
10 |
78 |
478 |
29 |
1 |
Cytoplasmic Alteration |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
12.5 mg/kg |
10 |
78 |
479 |
29 |
1 |
Cytoplasmic Alteration |
Marked |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
12.5 mg/kg |
10 |
78 |
480 |
29 |
1 |
Cytoplasmic Alteration |
Moderate |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
25 mg/kg |
10 |
79 |
481 |
29 |
1 |
Cytoplasmic Alteration |
Marked |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
25 mg/kg |
10 |
79 |
482 |
29 |
1 |
Cytoplasmic Alteration |
Marked |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
25 mg/kg |
10 |
79 |
483 |
29 |
1 |
Cytoplasmic Alteration |
Marked |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
25 mg/kg |
10 |
79 |
484 |
29 |
1 |
Cytoplasmic Alteration |
Marked |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
25 mg/kg |
10 |
79 |
485 |
29 |
1 |
Cytoplasmic Alteration |
Marked |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
25 mg/kg |
10 |
80 |
486 |
29 |
1 |
Cytoplasmic Alteration |
Marked |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
25 mg/kg |
10 |
80 |
487 |
29 |
1 |
Cytoplasmic Alteration |
Marked |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
25 mg/kg |
10 |
80 |
488 |
29 |
1 |
Cytoplasmic Alteration |
Marked |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
25 mg/kg |
10 |
80 |
489 |
29 |
1 |
Cytoplasmic Alteration |
Marked |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
25 mg/kg |
10 |
80 |
490 |
29 |
1 |
Cytoplasmic Alteration |
Marked |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
6.25 mg/kg |
10 |
75 |
462 |
29 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
6.25 mg/kg |
10 |
75 |
463 |
29 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
6.25 mg/kg |
10 |
75 |
464 |
29 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
6.25 mg/kg |
10 |
76 |
468 |
29 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
6.25 mg/kg |
10 |
76 |
469 |
29 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
12.5 mg/kg |
10 |
77 |
471 |
29 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
12.5 mg/kg |
10 |
77 |
472 |
29 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
12.5 mg/kg |
10 |
77 |
473 |
29 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
12.5 mg/kg |
10 |
77 |
474 |
29 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
12.5 mg/kg |
10 |
77 |
475 |
29 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
12.5 mg/kg |
10 |
78 |
476 |
29 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
12.5 mg/kg |
10 |
78 |
477 |
29 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
12.5 mg/kg |
10 |
78 |
478 |
29 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
12.5 mg/kg |
10 |
78 |
479 |
29 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
12.5 mg/kg |
10 |
78 |
480 |
29 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
25 mg/kg |
10 |
79 |
481 |
29 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
25 mg/kg |
10 |
79 |
482 |
29 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
25 mg/kg |
10 |
79 |
483 |
29 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
25 mg/kg |
10 |
79 |
484 |
29 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
25 mg/kg |
10 |
79 |
485 |
29 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
25 mg/kg |
10 |
80 |
486 |
29 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
25 mg/kg |
10 |
80 |
487 |
29 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
25 mg/kg |
10 |
80 |
488 |
29 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
25 mg/kg |
10 |
80 |
489 |
29 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
25 mg/kg |
10 |
80 |
490 |
29 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
73 |
451 |
29 |
1 |
Hepatodiaphragmatic Nodule |
|
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
74 |
458 |
29 |
1 |
Infiltration Cellular |
Minimal, Mixed Cell |
Terminal Sacrifice |
Alimentary System |
Liver |
|
6.25 mg/kg |
10 |
75 |
464 |
29 |
1 |
Infiltration Cellular |
Minimal, Mixed Cell |
Terminal Sacrifice |
Alimentary System |
Liver |
|
6.25 mg/kg |
10 |
76 |
467 |
29 |
1 |
Infiltration Cellular |
Minimal, Mixed Cell |
Terminal Sacrifice |
Alimentary System |
Liver |
|
12.5 mg/kg |
10 |
77 |
472 |
29 |
1 |
Infiltration Cellular |
Minimal, Mixed Cell |
Terminal Sacrifice |
Alimentary System |
Liver |
|
12.5 mg/kg |
10 |
77 |
474 |
29 |
1 |
Infiltration Cellular |
Minimal, Mixed Cell |
Terminal Sacrifice |
Alimentary System |
Liver |
|
25 mg/kg |
10 |
79 |
483 |
29 |
1 |
Infiltration Cellular |
Minimal, Mixed Cell |
Terminal Sacrifice |
Alimentary System |
Liver |
|
25 mg/kg |
10 |
80 |
486 |
29 |
1 |
Infiltration Cellular |
Minimal, Mixed Cell |
Terminal Sacrifice |
Alimentary System |
Liver |
|
25 mg/kg |
10 |
80 |
487 |
29 |
1 |
Infiltration Cellular |
Minimal, Mixed Cell |
Terminal Sacrifice |
Alimentary System |
Liver |
|
25 mg/kg |
10 |
80 |
490 |
29 |
1 |
Infiltration Cellular |
Minimal, Mixed Cell |
Terminal Sacrifice |
Alimentary System |
Pancreas |
Acinar Cell |
25 mg/kg |
10 |
79 |
484 |
29 |
1 |
Atrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Pancreas |
|
Vehicle Control |
10 |
73 |
451 |
29 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Stomach, Glandular |
|
25 mg/kg |
10 |
79 |
485 |
29 |
1 |
Mineral |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
Vehicle Control |
10 |
73 |
451 |
29 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
10 |
74 |
457 |
29 |
1 |
Mineral |
Mild |
Terminal Sacrifice |
Endocrine System |
Adrenal Cortex |
|
Vehicle Control |
10 |
74 |
457 |
29 |
1 |
Vacuolization Cytoplasmic |
Minimal |
Terminal Sacrifice |
Genital System |
Epididymis |
Duct |
25 mg/kg |
10 |
79 |
485 |
29 |
1 |
Exfoliated Germ Cell |
Minimal |
Terminal Sacrifice |
Genital System |
Epididymis |
|
Vehicle Control |
10 |
74 |
457 |
29 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Genital System |
Testes |
Germinal Epith |
25 mg/kg |
10 |
79 |
485 |
29 |
1 |
Degeneration |
Mild |
Terminal Sacrifice |
Respiratory System |
Lung |
|
25 mg/kg |
10 |
79 |
485 |
29 |
1 |
Infiltration Cellular |
Minimal |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
73 |
451 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
73 |
454 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
73 |
455 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
74 |
456 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
74 |
458 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
74 |
460 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
6.25 mg/kg |
10 |
75 |
461 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
6.25 mg/kg |
10 |
76 |
467 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
6.25 mg/kg |
10 |
76 |
468 |
29 |
1 |
Nephropathy |
Mild, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
6.25 mg/kg |
10 |
76 |
470 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
12.5 mg/kg |
10 |
77 |
472 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
12.5 mg/kg |
10 |
77 |
473 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
12.5 mg/kg |
10 |
77 |
474 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
12.5 mg/kg |
10 |
77 |
475 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
12.5 mg/kg |
10 |
78 |
476 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
12.5 mg/kg |
10 |
78 |
477 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
12.5 mg/kg |
10 |
78 |
478 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
12.5 mg/kg |
10 |
78 |
479 |
29 |
1 |
Nephropathy |
Mild, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
25 mg/kg |
10 |
79 |
481 |
29 |
1 |
Nephropathy |
Mild, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
25 mg/kg |
10 |
79 |
483 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
25 mg/kg |
10 |
79 |
484 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
25 mg/kg |
10 |
79 |
485 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
25 mg/kg |
10 |
80 |
487 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
25 mg/kg |
10 |
80 |
488 |
29 |
1 |
Nephropathy |
Mild, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
25 mg/kg |
10 |
80 |
489 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |