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Short-Term Individual Animal Non Neoplastic Diagnosis
Study Information:
Chemical Name: | Perfluorobutane sulfonate (PFBS) |
CASRN: | ="375-73-5" |
Study Number: | C07040 |
Exposure Route: | GAVAGE |
TDMS Number: | 0704001 |
Sex: | Male |
Strain and Species: | HSD Rats |
Male Individual Animal Non Neoplastic Diagnoses
System |
Organ |
Site |
Treatment Group |
Number Examined |
Cage Number |
Animal Number |
Days on Study |
Lesion Found |
Lesion Name |
Lesion Qualifier |
Removal Reason |
Alimentary System |
Esophagus |
|
1000 mg/kg |
10 |
36 |
210 |
6 |
1 |
Hemorrhage |
Moderate |
Dosing Accident |
Alimentary System |
Esophagus |
|
500 mg/kg |
10 |
33 |
191 |
29 |
1 |
Inflammation |
Minimal, Chronic |
Terminal Sacrifice |
Alimentary System |
Esophagus |
|
1000 mg/kg |
10 |
36 |
206 |
25 |
1 |
Inflammation |
Mild, Chronic |
Natural Death |
Alimentary System |
Esophagus |
|
1000 mg/kg |
10 |
36 |
210 |
6 |
1 |
Perforation |
Moderate |
Dosing Accident |
Alimentary System |
Intestine Large |
Colon |
Vehicle Control |
10 |
25 |
155 |
29 |
1 |
Infiltration Cellular |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
125 mg/kg |
10 |
30 |
176 |
29 |
1 |
Cytoplasmic Alteration |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
500 mg/kg |
10 |
33 |
191 |
29 |
1 |
Cytoplasmic Alteration |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
500 mg/kg |
10 |
33 |
192 |
29 |
1 |
Cytoplasmic Alteration |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
500 mg/kg |
10 |
33 |
193 |
29 |
1 |
Cytoplasmic Alteration |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
500 mg/kg |
10 |
33 |
194 |
29 |
1 |
Cytoplasmic Alteration |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
500 mg/kg |
10 |
33 |
195 |
29 |
1 |
Cytoplasmic Alteration |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
500 mg/kg |
10 |
34 |
196 |
29 |
1 |
Cytoplasmic Alteration |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
500 mg/kg |
10 |
34 |
197 |
29 |
1 |
Cytoplasmic Alteration |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
500 mg/kg |
10 |
34 |
198 |
29 |
1 |
Cytoplasmic Alteration |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
500 mg/kg |
10 |
34 |
199 |
29 |
1 |
Cytoplasmic Alteration |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
500 mg/kg |
10 |
34 |
200 |
29 |
1 |
Cytoplasmic Alteration |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
1000 mg/kg |
10 |
35 |
201 |
15 |
1 |
Cytoplasmic Alteration |
Mild |
Natural Death |
Alimentary System |
Liver |
Hepatocyte |
1000 mg/kg |
10 |
35 |
202 |
18 |
1 |
Cytoplasmic Alteration |
Mild |
Natural Death |
Alimentary System |
Liver |
Hepatocyte |
1000 mg/kg |
10 |
35 |
203 |
25 |
1 |
Cytoplasmic Alteration |
Minimal |
Natural Death |
Alimentary System |
Liver |
Hepatocyte |
1000 mg/kg |
10 |
35 |
204 |
24 |
1 |
Cytoplasmic Alteration |
Mild |
Natural Death |
Alimentary System |
Liver |
Hepatocyte |
1000 mg/kg |
10 |
35 |
205 |
18 |
1 |
Cytoplasmic Alteration |
Minimal |
Natural Death |
Alimentary System |
Liver |
Hepatocyte |
1000 mg/kg |
10 |
36 |
206 |
25 |
1 |
Cytoplasmic Alteration |
Minimal |
Natural Death |
Alimentary System |
Liver |
Hepatocyte |
1000 mg/kg |
10 |
36 |
207 |
21 |
1 |
Cytoplasmic Alteration |
Mild |
Natural Death |
Alimentary System |
Liver |
Hepatocyte |
1000 mg/kg |
10 |
36 |
208 |
18 |
1 |
Cytoplasmic Alteration |
Mild |
Natural Death |
Alimentary System |
Liver |
Hepatocyte |
1000 mg/kg |
10 |
36 |
209 |
17 |
1 |
Cytoplasmic Alteration |
Minimal |
Natural Death |
Alimentary System |
Liver |
Hepatocyte |
125 mg/kg |
10 |
29 |
171 |
29 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
125 mg/kg |
10 |
29 |
172 |
29 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
125 mg/kg |
10 |
29 |
173 |
29 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
125 mg/kg |
10 |
29 |
174 |
29 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
125 mg/kg |
10 |
29 |
175 |
29 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
125 mg/kg |
10 |
30 |
176 |
29 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
125 mg/kg |
10 |
30 |
177 |
29 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
125 mg/kg |
10 |
30 |
178 |
29 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
125 mg/kg |
10 |
30 |
180 |
29 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
250 mg/kg |
10 |
31 |
181 |
29 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
250 mg/kg |
10 |
31 |
182 |
29 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
250 mg/kg |
10 |
31 |
183 |
29 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
250 mg/kg |
10 |
31 |
184 |
29 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
250 mg/kg |
10 |
31 |
185 |
29 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
250 mg/kg |
10 |
32 |
186 |
29 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
250 mg/kg |
10 |
32 |
187 |
29 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
250 mg/kg |
10 |
32 |
188 |
29 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
250 mg/kg |
10 |
32 |
189 |
29 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
250 mg/kg |
10 |
32 |
190 |
29 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
500 mg/kg |
10 |
33 |
191 |
29 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
500 mg/kg |
10 |
33 |
192 |
29 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
500 mg/kg |
10 |
33 |
193 |
29 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
500 mg/kg |
10 |
33 |
194 |
29 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
500 mg/kg |
10 |
33 |
195 |
29 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
500 mg/kg |
10 |
34 |
196 |
29 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
500 mg/kg |
10 |
34 |
197 |
29 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
500 mg/kg |
10 |
34 |
198 |
29 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
500 mg/kg |
10 |
34 |
199 |
29 |
1 |
Hypertrophy |
Mild |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
500 mg/kg |
10 |
34 |
200 |
29 |
1 |
Hypertrophy |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
Hepatocyte |
1000 mg/kg |
10 |
35 |
201 |
15 |
1 |
Hypertrophy |
Moderate |
Natural Death |
Alimentary System |
Liver |
Hepatocyte |
1000 mg/kg |
10 |
35 |
202 |
18 |
1 |
Hypertrophy |
Minimal |
Natural Death |
Alimentary System |
Liver |
Hepatocyte |
1000 mg/kg |
10 |
35 |
203 |
25 |
1 |
Hypertrophy |
Moderate |
Natural Death |
Alimentary System |
Liver |
Hepatocyte |
1000 mg/kg |
10 |
35 |
204 |
24 |
1 |
Hypertrophy |
Mild |
Natural Death |
Alimentary System |
Liver |
Hepatocyte |
1000 mg/kg |
10 |
35 |
205 |
18 |
1 |
Hypertrophy |
Mild |
Natural Death |
Alimentary System |
Liver |
Hepatocyte |
1000 mg/kg |
10 |
36 |
206 |
25 |
1 |
Hypertrophy |
Mild |
Natural Death |
Alimentary System |
Liver |
Hepatocyte |
1000 mg/kg |
10 |
36 |
207 |
21 |
1 |
Hypertrophy |
Mild |
Natural Death |
Alimentary System |
Liver |
Hepatocyte |
1000 mg/kg |
10 |
36 |
208 |
18 |
1 |
Hypertrophy |
Mild |
Natural Death |
Alimentary System |
Liver |
Hepatocyte |
1000 mg/kg |
10 |
36 |
209 |
17 |
1 |
Hypertrophy |
Mild |
Natural Death |
Alimentary System |
Liver |
|
1000 mg/kg |
10 |
35 |
202 |
18 |
1 |
Hemorrhage |
Mild |
Natural Death |
Alimentary System |
Liver |
|
62.6 mg/kg |
10 |
28 |
170 |
29 |
1 |
Hepatodiaphragmatic Nodule |
Minimal |
Terminal Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
10 |
36 |
207 |
21 |
1 |
Hepatodiaphragmatic Nodule |
Mild |
Natural Death |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
25 |
154 |
29 |
1 |
Infiltration Cellular |
Minimal, Mixed Cell |
Terminal Sacrifice |
Alimentary System |
Liver |
|
Vehicle Control |
10 |
25 |
155 |
29 |
1 |
Infiltration Cellular |
Minimal, Mixed Cell |
Terminal Sacrifice |
Alimentary System |
Liver |
|
62.6 mg/kg |
10 |
27 |
165 |
29 |
1 |
Infiltration Cellular |
Minimal, Mixed Cell |
Terminal Sacrifice |
Alimentary System |
Liver |
|
125 mg/kg |
10 |
29 |
173 |
29 |
1 |
Infiltration Cellular |
Minimal, Mixed Cell |
Terminal Sacrifice |
Alimentary System |
Liver |
|
125 mg/kg |
10 |
29 |
174 |
29 |
1 |
Infiltration Cellular |
Minimal, Mixed Cell |
Terminal Sacrifice |
Alimentary System |
Liver |
|
250 mg/kg |
10 |
31 |
184 |
29 |
1 |
Infiltration Cellular |
Minimal, Mixed Cell |
Terminal Sacrifice |
Alimentary System |
Liver |
|
250 mg/kg |
10 |
31 |
185 |
29 |
1 |
Infiltration Cellular |
Minimal, Mixed Cell |
Terminal Sacrifice |
Alimentary System |
Liver |
|
250 mg/kg |
10 |
32 |
188 |
29 |
1 |
Infiltration Cellular |
Minimal, Mixed Cell |
Terminal Sacrifice |
Alimentary System |
Liver |
|
500 mg/kg |
10 |
33 |
194 |
29 |
1 |
Infiltration Cellular |
Minimal, Mixed Cell |
Terminal Sacrifice |
Alimentary System |
Liver |
|
1000 mg/kg |
10 |
35 |
202 |
18 |
1 |
Necrosis |
Moderate |
Natural Death |
Alimentary System |
Stomach, Forestomach |
Epithelium |
500 mg/kg |
10 |
33 |
191 |
29 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Alimentary System |
Stomach, Forestomach |
Epithelium |
1000 mg/kg |
10 |
36 |
210 |
6 |
1 |
Hyperplasia |
Mild |
Dosing Accident |
Alimentary System |
Stomach, Forestomach |
Epithelium |
1000 mg/kg |
10 |
35 |
201 |
15 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Alimentary System |
Stomach, Forestomach |
Epithelium |
1000 mg/kg |
10 |
35 |
202 |
18 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Alimentary System |
Stomach, Forestomach |
Epithelium |
1000 mg/kg |
10 |
35 |
203 |
25 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Alimentary System |
Stomach, Forestomach |
Epithelium |
1000 mg/kg |
10 |
36 |
207 |
21 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Alimentary System |
Stomach, Forestomach |
Epithelium |
1000 mg/kg |
10 |
36 |
208 |
18 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Alimentary System |
Stomach, Forestomach |
|
1000 mg/kg |
10 |
36 |
210 |
6 |
1 |
Inflammation |
Minimal, Acute |
Dosing Accident |
Cardiovascular System |
Heart |
|
Vehicle Control |
10 |
26 |
158 |
29 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Cardiovascular System |
Heart |
|
500 mg/kg |
10 |
33 |
191 |
29 |
1 |
Cardiomyopathy |
Minimal |
Terminal Sacrifice |
Genital System |
Epididymis |
Duct |
1000 mg/kg |
10 |
35 |
201 |
15 |
1 |
Exfoliated Germ Cell |
Minimal |
Natural Death |
Genital System |
Epididymis |
Duct |
1000 mg/kg |
10 |
35 |
202 |
18 |
1 |
Exfoliated Germ Cell |
Minimal |
Natural Death |
Genital System |
Testes |
Germinal Epith |
1000 mg/kg |
10 |
36 |
207 |
21 |
1 |
Degeneration |
Minimal |
Natural Death |
Hematopoietic System |
Bone Marrow |
|
1000 mg/kg |
10 |
36 |
210 |
6 |
1 |
Hypocellularity |
Mild |
Dosing Accident |
Hematopoietic System |
Bone Marrow |
|
1000 mg/kg |
10 |
35 |
201 |
15 |
1 |
Hypocellularity |
Mild |
Natural Death |
Hematopoietic System |
Bone Marrow |
|
1000 mg/kg |
10 |
35 |
202 |
18 |
1 |
Hypocellularity |
Mild |
Natural Death |
Hematopoietic System |
Bone Marrow |
|
1000 mg/kg |
10 |
35 |
203 |
25 |
1 |
Hypocellularity |
Moderate |
Natural Death |
Hematopoietic System |
Bone Marrow |
|
1000 mg/kg |
10 |
35 |
204 |
24 |
1 |
Hypocellularity |
Moderate |
Natural Death |
Hematopoietic System |
Bone Marrow |
|
1000 mg/kg |
10 |
35 |
205 |
18 |
1 |
Hypocellularity |
Moderate |
Natural Death |
Hematopoietic System |
Bone Marrow |
|
1000 mg/kg |
10 |
36 |
206 |
25 |
1 |
Hypocellularity |
Moderate |
Natural Death |
Hematopoietic System |
Bone Marrow |
|
1000 mg/kg |
10 |
36 |
207 |
21 |
1 |
Hypocellularity |
Moderate |
Natural Death |
Hematopoietic System |
Bone Marrow |
|
1000 mg/kg |
10 |
36 |
208 |
18 |
1 |
Hypocellularity |
Mild |
Natural Death |
Hematopoietic System |
Bone Marrow |
|
1000 mg/kg |
10 |
36 |
209 |
17 |
1 |
Hypocellularity |
Moderate |
Natural Death |
Hematopoietic System |
Thymus |
|
1000 mg/kg |
10 |
35 |
201 |
15 |
1 |
Atrophy |
Moderate |
Natural Death |
Hematopoietic System |
Thymus |
|
1000 mg/kg |
10 |
35 |
203 |
25 |
1 |
Atrophy |
Moderate |
Natural Death |
Hematopoietic System |
Thymus |
|
1000 mg/kg |
10 |
36 |
206 |
25 |
1 |
Atrophy |
Moderate |
Natural Death |
Hematopoietic System |
Thymus |
|
1000 mg/kg |
10 |
36 |
207 |
21 |
1 |
Atrophy |
Marked |
Natural Death |
Hematopoietic System |
Thymus |
|
1000 mg/kg |
10 |
36 |
208 |
18 |
1 |
Atrophy |
Moderate |
Natural Death |
Respiratory System |
Lung |
Alveolar Epith |
500 mg/kg |
10 |
34 |
196 |
29 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Lung |
Alveolar Epith |
1000 mg/kg |
10 |
35 |
203 |
25 |
1 |
Hyperplasia |
Mild |
Natural Death |
Respiratory System |
Lung |
Perivascular |
1000 mg/kg |
10 |
36 |
210 |
6 |
1 |
Inflammation |
Minimal, Acute |
Dosing Accident |
Respiratory System |
Lung |
|
Vehicle Control |
10 |
26 |
158 |
29 |
1 |
Erythrophagocytosis |
Minimal |
Terminal Sacrifice |
Respiratory System |
Lung |
|
500 mg/kg |
10 |
34 |
196 |
29 |
1 |
Erythrophagocytosis |
Minimal |
Terminal Sacrifice |
Respiratory System |
Lung |
|
1000 mg/kg |
10 |
35 |
203 |
25 |
1 |
Fibrosis |
Mild |
Natural Death |
Respiratory System |
Lung |
|
1000 mg/kg |
10 |
36 |
210 |
6 |
1 |
Hemorrhage |
Mild |
Dosing Accident |
Respiratory System |
Lung |
|
1000 mg/kg |
10 |
35 |
203 |
25 |
1 |
Hemorrhage |
Mild |
Natural Death |
Respiratory System |
Lung |
|
Vehicle Control |
10 |
26 |
158 |
29 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Respiratory System |
Lung |
|
500 mg/kg |
10 |
33 |
193 |
29 |
1 |
Infiltration Cellular |
Minimal, Mononuclear Cl |
Terminal Sacrifice |
Respiratory System |
Lung |
|
500 mg/kg |
10 |
34 |
196 |
29 |
1 |
Infiltration Cellular |
Minimal, Histiocyte |
Terminal Sacrifice |
Respiratory System |
Lung |
|
Vehicle Control |
10 |
26 |
158 |
29 |
1 |
Inflammation |
Minimal, Chronic Active |
Terminal Sacrifice |
Respiratory System |
Lung |
|
1000 mg/kg |
10 |
35 |
203 |
25 |
1 |
Inflammation |
Mild, Chronic Active |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
125 mg/kg |
10 |
29 |
173 |
29 |
1 |
Degeneration |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
125 mg/kg |
10 |
29 |
175 |
29 |
1 |
Degeneration |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
125 mg/kg |
10 |
30 |
176 |
29 |
1 |
Degeneration |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
250 mg/kg |
10 |
31 |
181 |
29 |
1 |
Degeneration |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
250 mg/kg |
10 |
31 |
182 |
29 |
1 |
Degeneration |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
250 mg/kg |
10 |
31 |
184 |
29 |
1 |
Degeneration |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
250 mg/kg |
10 |
31 |
185 |
29 |
1 |
Degeneration |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
250 mg/kg |
10 |
32 |
186 |
29 |
1 |
Degeneration |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
250 mg/kg |
10 |
32 |
187 |
29 |
1 |
Degeneration |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
250 mg/kg |
10 |
32 |
188 |
29 |
1 |
Degeneration |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
500 mg/kg |
10 |
33 |
191 |
29 |
1 |
Degeneration |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
500 mg/kg |
10 |
33 |
192 |
29 |
1 |
Degeneration |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
500 mg/kg |
10 |
33 |
193 |
29 |
1 |
Degeneration |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
500 mg/kg |
10 |
33 |
194 |
29 |
1 |
Degeneration |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
500 mg/kg |
10 |
33 |
195 |
29 |
1 |
Degeneration |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
500 mg/kg |
10 |
34 |
196 |
29 |
1 |
Degeneration |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
500 mg/kg |
10 |
34 |
197 |
29 |
1 |
Degeneration |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
500 mg/kg |
10 |
34 |
198 |
29 |
1 |
Degeneration |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
500 mg/kg |
10 |
34 |
200 |
29 |
1 |
Degeneration |
Moderate |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
10 |
36 |
210 |
6 |
1 |
Degeneration |
Mild |
Dosing Accident |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
10 |
35 |
201 |
15 |
1 |
Degeneration |
Mild |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
10 |
35 |
202 |
18 |
1 |
Degeneration |
Mild |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
10 |
35 |
203 |
25 |
1 |
Degeneration |
Mild |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
10 |
35 |
204 |
24 |
1 |
Degeneration |
Moderate |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
10 |
35 |
205 |
18 |
1 |
Degeneration |
Mild |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
10 |
36 |
206 |
25 |
1 |
Degeneration |
Moderate |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
10 |
36 |
207 |
21 |
1 |
Degeneration |
Moderate |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
10 |
36 |
209 |
17 |
1 |
Degeneration |
Mild |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
125 mg/kg |
10 |
29 |
175 |
29 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
125 mg/kg |
10 |
30 |
176 |
29 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
250 mg/kg |
10 |
31 |
181 |
29 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
250 mg/kg |
10 |
31 |
182 |
29 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
250 mg/kg |
10 |
31 |
185 |
29 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
250 mg/kg |
10 |
32 |
187 |
29 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
250 mg/kg |
10 |
32 |
188 |
29 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
500 mg/kg |
10 |
33 |
191 |
29 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
500 mg/kg |
10 |
33 |
192 |
29 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
500 mg/kg |
10 |
33 |
193 |
29 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
500 mg/kg |
10 |
33 |
194 |
29 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
500 mg/kg |
10 |
33 |
195 |
29 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
500 mg/kg |
10 |
34 |
196 |
29 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
500 mg/kg |
10 |
34 |
197 |
29 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
500 mg/kg |
10 |
34 |
198 |
29 |
1 |
Hyperplasia |
Minimal |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
500 mg/kg |
10 |
34 |
200 |
29 |
1 |
Hyperplasia |
Mild |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
10 |
36 |
210 |
6 |
1 |
Hyperplasia |
Mild |
Dosing Accident |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
10 |
35 |
201 |
15 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
10 |
36 |
206 |
25 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
10 |
36 |
207 |
21 |
1 |
Hyperplasia |
Minimal |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
10 |
36 |
209 |
17 |
1 |
Hyperplasia |
Mild |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
250 mg/kg |
10 |
31 |
184 |
29 |
1 |
Inflammation |
Minimal, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
250 mg/kg |
10 |
32 |
188 |
29 |
1 |
Inflammation |
Minimal, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
500 mg/kg |
10 |
33 |
194 |
29 |
1 |
Inflammation |
Minimal, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
500 mg/kg |
10 |
34 |
200 |
29 |
1 |
Inflammation |
Mild, Suppurative |
Terminal Sacrifice |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
10 |
36 |
210 |
6 |
1 |
Inflammation |
Moderate, Suppurative |
Dosing Accident |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
10 |
35 |
201 |
15 |
1 |
Inflammation |
Moderate, Suppurative |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
10 |
35 |
202 |
18 |
1 |
Inflammation |
Minimal, Suppurative |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
10 |
35 |
203 |
25 |
1 |
Inflammation |
Mild, Suppurative |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
10 |
35 |
204 |
24 |
1 |
Inflammation |
Marked, Suppurative |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
10 |
35 |
205 |
18 |
1 |
Inflammation |
Mild, Suppurative |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
10 |
36 |
206 |
25 |
1 |
Inflammation |
Moderate, Suppurative |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
10 |
36 |
207 |
21 |
1 |
Inflammation |
Moderate, Suppurative |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
10 |
36 |
209 |
17 |
1 |
Inflammation |
Minimal, Suppurative |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
10 |
36 |
210 |
6 |
1 |
Necrosis |
Mild |
Dosing Accident |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
10 |
35 |
202 |
18 |
1 |
Necrosis |
Moderate |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
10 |
35 |
203 |
25 |
1 |
Necrosis |
Minimal |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
10 |
35 |
204 |
24 |
1 |
Necrosis |
Minimal |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
10 |
35 |
205 |
18 |
1 |
Necrosis |
Moderate |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
10 |
36 |
207 |
21 |
1 |
Necrosis |
Minimal |
Natural Death |
Respiratory System |
Nose |
Olfactory Epi |
1000 mg/kg |
10 |
36 |
209 |
17 |
1 |
Necrosis |
Moderate |
Natural Death |
Special Senses System |
Harderian Gland |
|
Vehicle Control |
10 |
25 |
153 |
29 |
1 |
Infiltration Cellular |
Mild, Mononuclear Cl |
Terminal Sacrifice |
Urinary System |
Kidney |
Papilla |
1000 mg/kg |
10 |
35 |
201 |
15 |
1 |
Necrosis |
Mild |
Natural Death |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
25 |
151 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
25 |
153 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
25 |
154 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
25 |
155 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
26 |
157 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
Vehicle Control |
10 |
26 |
158 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
62.6 mg/kg |
10 |
27 |
162 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
62.6 mg/kg |
10 |
27 |
163 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
62.6 mg/kg |
10 |
28 |
167 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
62.6 mg/kg |
10 |
28 |
169 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
125 mg/kg |
10 |
29 |
175 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
125 mg/kg |
10 |
30 |
176 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
250 mg/kg |
10 |
31 |
181 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
250 mg/kg |
10 |
31 |
184 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
250 mg/kg |
10 |
31 |
185 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
250 mg/kg |
10 |
32 |
186 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
250 mg/kg |
10 |
32 |
187 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
250 mg/kg |
10 |
32 |
189 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
500 mg/kg |
10 |
33 |
193 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
500 mg/kg |
10 |
33 |
195 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
500 mg/kg |
10 |
34 |
197 |
29 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Terminal Sacrifice |
Urinary System |
Kidney |
|
1000 mg/kg |
10 |
35 |
201 |
15 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Natural Death |
Urinary System |
Kidney |
|
1000 mg/kg |
10 |
36 |
206 |
25 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Natural Death |
Urinary System |
Kidney |
|
1000 mg/kg |
10 |
36 |
209 |
17 |
1 |
Nephropathy |
Minimal, Chronicprogr |
Natural Death |