Background

Attached are data files for your analysis. I have specified in each sheet what the requested comparisons are. They are very similar to those that we’ve sent you previously for our first paper together. I totally understand if you can’t get through all data before the holidays, but if you could prioritize the HEC-1 data file, that would be great. Please feel free to reach out if you have any questions!

list of all files and sheets

4 excel files

  • File 1 (Ishikawa PFAS + Carboplatin.xlsx): with 1 sheet in total …
    • Sheet 1: Please compare each exposure group to the methanol group at each carboplatin dose.
  • File 2 (05.01.2023 HEC-1 Data for Xianming FINAL.xlsx): with 9 sheets in total …
    • Sheet 1: Please compare each treatment group to the 0 Carb group
  • File 3 (Ishikawa Data for Xianming.xlsx): with 12 sheets in total …
  • File 4 (OvCa mtDNA and ROS Data for Xianming.xlsx) with 12 sheet2 in total …

For file 1: “Ishikawa PFAS + Carboplatin.xlsx”

  • Only one sheet in this file
  • Sheet 1: Please compare each exposure group to the methanol group at each carboplatin dose.

Sheet1

Table 1 Exposure = 0uM Carboplatin
contrast estimate SE df t.ratio p.value
2uM PFHpA - Methanol -0.1535885 0.0483410 47 -3.1771895 0.0182525
2uM PFOA - Methanol -0.0606653 0.0483410 47 -1.2549457 0.8174573
2uM PFPA - Methanol -0.0177185 0.0483410 47 -0.3665313 0.9998496
500nM PFHpA - Methanol -0.0865933 0.0483410 47 -1.7913012 0.4408164
500nM PFOA - Methanol -0.0412349 0.0483410 47 -0.8530008 0.9713417
500nM PFPA - Methanol 0.0086858 0.0483410 47 0.1796778 0.9999988
Media - Methanol 0.1495085 0.0796422 47 1.8772521 0.3831838
Table 1 Exposure = 50uM Carboplatin
contrast estimate SE df t.ratio p.value
2uM PFHpA - Methanol -0.0379732 0.0479148 47 -0.7925150 0.9809362
2uM PFOA - Methanol 0.0357270 0.0479148 47 0.7456352 0.9865413
2uM PFPA - Methanol -0.0257259 0.0479148 47 -0.5369091 0.9981773
500nM PFHpA - Methanol 0.0029247 0.0479148 47 0.0610387 1.0000000
500nM PFOA - Methanol 0.0269481 0.0479148 47 0.5624163 0.9975569
500nM PFPA - Methanol -0.0410517 0.0479148 47 -0.8567647 0.9706472
Media - Methanol 0.1736241 0.0789401 47 2.1994415 0.2082090
Table 1 Exposure = 100uM Carboplatin
contrast estimate SE df t.ratio p.value
2uM PFHpA - Methanol -0.1146171 0.0507481 47 -2.2585506 0.1837763
2uM PFOA - Methanol -0.0276647 0.0507481 47 -0.5451374 0.9979931
2uM PFPA - Methanol 0.0655206 0.0507481 47 1.2910965 0.7957006
500nM PFHpA - Methanol -0.0668433 0.0507481 47 -1.3171588 0.7793521
500nM PFOA - Methanol -0.0115508 0.0507481 47 -0.2276106 0.9999941
500nM PFPA - Methanol -0.0117955 0.0507481 47 -0.2324329 0.9999932
Media - Methanol 0.1087058 0.0836079 47 1.3001854 0.7900598
Table 1 Exposure = 200uM Carboplatin
contrast estimate SE df t.ratio p.value
2uM PFHpA - Methanol -0.1412907 0.0742601 47 -1.9026452 0.3669290
2uM PFOA - Methanol -0.1518444 0.0742601 47 -2.0447640 0.2834581
2uM PFPA - Methanol -0.0644744 0.0742601 47 -0.8682240 0.9684583
500nM PFHpA - Methanol -0.1524964 0.0742601 47 -2.0535429 0.2787442
500nM PFOA - Methanol -0.0809649 0.0742601 47 -1.0902874 0.9008051
500nM PFPA - Methanol -0.0290044 0.0742601 47 -0.3905789 0.9997702
Media - Methanol 0.2686645 0.1223442 47 2.1959720 0.2097161
Table 1 Exposure = 400uM Carboplatin
contrast estimate SE df t.ratio p.value
2uM PFHpA - Methanol -0.0463194 0.0885532 47 -0.5230684 0.9984562
2uM PFOA - Methanol -0.0334052 0.0885532 47 -0.3772336 0.9998177
2uM PFPA - Methanol -0.1327859 0.0885532 47 -1.4995039 0.6532900
500nM PFHpA - Methanol -0.0709768 0.0885532 47 -0.8015156 0.9796864
500nM PFOA - Methanol 0.0355177 0.0885532 47 0.4010884 0.9997259
500nM PFPA - Methanol -0.1457534 0.0885532 47 -1.6459409 0.5451802
Media - Methanol 0.4116875 0.1458922 47 2.8218602 0.0478205

For file 2: “05.01.2023 HEC-1 Data for Xianming FINAL.xlsx”

  • There are length(mysheets) sheets in this file
  • Sheet 1: Please compare each treatment group to the 0 Carb group. (level 1, no control for dose)
Table 1
contrast estimate SE df t.ratio p.value
0 Carb - 100uM Carb 0.5737138 0.0481355 108 11.9187379 0.0000000
0 Carb - 10uM Carb -0.0629683 0.0481355 108 -1.3081484 0.8558041
0 Carb - 1uM Carb -0.0344700 0.0481355 108 -0.7161044 0.9969945
0 Carb - 2.5uM Carb -0.0286711 0.0481355 108 -0.5956347 0.9992827
0 Carb - 200uM Carb 0.9378370 0.0481355 108 19.4832912 0.0000000
0 Carb - 25uM Carb -0.0371411 0.0481355 108 -0.7715954 0.9947588
0 Carb - 400uM Carb 0.9391986 0.0481355 108 19.5115781 0.0000000
0 Carb - 50uM Carb 0.0376924 0.0481355 108 0.7830480 0.9941619
0 Carb - 5uM Carb -0.0448133 0.0481355 108 -0.9309841 0.9803905

[1] 2

  • Sheet 2: Please compare each exposure group to the 1% methanol group. (level 2, no control for dose)
    Table 2
    contrast estimate SE df t.ratio p.value
    (100nM PFOA + 100nM PFHpA + 100nM PFPA) - Methanol -0.0359715 0.0280568 71 -1.2820986 0.6803877
    (750nM PFHpA + 750nM PFPA) - Methanol 0.0085836 0.0280568 71 0.3059384 0.9992128
    (750nM PFOA + 750nM PFHpA) - Methanol -0.0450676 0.0280568 71 -1.6063028 0.4498461
    (750nM PFOA + 750nM PFPA) - Methanol -0.0784764 0.0280568 71 -2.7970609 0.0327210
    Media - Methanol -0.0426815 0.0259755 71 -1.6431432 0.4250091

[1] 3

  • Sheet 3: Please compare each exposure group to the 1% methanol group at each carboplatin dose
    Table 3 Exposure = 0 Carb
    contrast estimate SE df t.ratio p.value
    1% Methanol - (1uM PFHpA + 1uM PFPA) -0.0308030 0.0353422 28 -0.8715634 0.9161332
    1% Methanol - (1uM PFOA + 1uM PFHpA) -0.0050834 0.0353422 28 -0.1438332 0.9999813
    1% Methanol - (1uM PFOA + 1uM PFPA) -0.0619518 0.0353422 28 -1.7529136 0.3778895
    1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA) -0.0066302 0.0353422 28 -0.1875997 0.9999303
    1% Methanol - Media 0.0156925 0.0353422 28 0.4440157 0.9954860
Table 3 Exposure = 50 Carb
contrast estimate SE df t.ratio p.value
1% Methanol - (1uM PFHpA + 1uM PFPA) -0.0364524 0.0410186 28 -0.8886808 0.9096694
1% Methanol - (1uM PFOA + 1uM PFHpA) -0.0121260 0.0410186 28 -0.2956221 0.9993522
1% Methanol - (1uM PFOA + 1uM PFPA) -0.0387807 0.0410186 28 -0.9454422 0.8862037
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA) -0.0036530 0.0410186 28 -0.0890574 0.9999983
1% Methanol - Media 0.0253512 0.0410186 28 0.6180415 0.9797468
Table 3 Exposure = 100 Carb
contrast estimate SE df t.ratio p.value
1% Methanol - (1uM PFHpA + 1uM PFPA) 0.0309099 0.0509984 28 0.6060944 0.9814103
1% Methanol - (1uM PFOA + 1uM PFHpA) 0.0231194 0.0509984 28 0.4533352 0.9950269
1% Methanol - (1uM PFOA + 1uM PFPA) 0.0160870 0.0509984 28 0.3154412 0.9991130
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA) 0.0408980 0.0509984 28 0.8019463 0.9394806
1% Methanol - Media 0.1230680 0.0509984 28 2.4131723 0.1080402
Table 3 Exposure = 200 Carb
contrast estimate SE df t.ratio p.value
1% Methanol - (1uM PFHpA + 1uM PFPA) 0.0082967 0.0606308 28 0.1368393 0.9999854
1% Methanol - (1uM PFOA + 1uM PFHpA) 0.0048947 0.0606308 28 0.0807290 0.9999989
1% Methanol - (1uM PFOA + 1uM PFPA) -0.0708274 0.0606308 28 -1.1681756 0.7667594
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA) -0.0200801 0.0606308 28 -0.3311861 0.9988782
1% Methanol - Media 0.4261276 0.0606308 28 7.0282364 0.0000006
Table 3 Exposure = 400 Carb
contrast estimate SE df t.ratio p.value
1% Methanol - (1uM PFHpA + 1uM PFPA) 0.1014040 0.0465953 28 2.1762724 0.1766456
1% Methanol - (1uM PFOA + 1uM PFHpA) -0.0605531 0.0465953 28 -1.2995535 0.6811371
1% Methanol - (1uM PFOA + 1uM PFPA) -0.0359202 0.0465953 28 -0.7708967 0.9483890
1% Methanol - (750nM PFOA + 750nM PFHpA + 750nM PFPA) 0.0164164 0.0465953 28 0.3523191 0.9984902
1% Methanol - Media 0.5913812 0.0465953 28 12.6918666 0.0000000

[1] 4

  • Sheet 4: Please compare each exposure group to the 1% methanol group at each carboplatin dose
Table 4 Exposure = 0 Carb
contrast estimate SE df t.ratio p.value
2uM PFHpA - Methanol 0.7274047 0.1062672 35 6.845056 0.0000004
2uM PFOA - Methanol 0.4768340 0.1062672 35 4.487125 0.0004481
2uM PFPA - Methanol 0.2902931 0.1062672 35 2.731729 0.0574044
500nM PFHpA - Methanol 0.5659293 0.1062672 35 5.325533 0.0000359
500nM PFOA - Methanol 0.1886930 0.1062672 35 1.775647 0.4111746
500nM PFPA - Methanol 0.1874229 0.1062672 35 1.763696 0.4189444
Table 4 Exposure = 50 Carb
contrast estimate SE df t.ratio p.value
2uM PFHpA - Methanol 0.6854386 0.0605255 35 11.3247863 0.0000000
2uM PFOA - Methanol 0.4520536 0.0605255 35 7.4688100 0.0000001
2uM PFPA - Methanol 0.1680355 0.0605255 35 2.7762743 0.0514834
500nM PFHpA - Methanol 0.4572676 0.0605255 35 7.5549542 0.0000000
500nM PFOA - Methanol 0.1413332 0.0605255 35 2.3351006 0.1430380
500nM PFPA - Methanol -0.0377051 0.0605255 35 -0.6229624 0.9901932
Table 4 Exposure = 100 Carb
contrast estimate SE df t.ratio p.value
2uM PFHpA - Methanol 0.6722375 0.0898251 35 7.4838493 0.0000001
2uM PFOA - Methanol 0.4702115 0.0898251 35 5.2347457 0.0000473
2uM PFPA - Methanol 0.1967658 0.0898251 35 2.1905438 0.1936409
500nM PFHpA - Methanol 0.5725109 0.0898251 35 6.3736190 0.0000015
500nM PFOA - Methanol 0.2080251 0.0898251 35 2.3158911 0.1490665
500nM PFPA - Methanol 0.0182294 0.0898251 35 0.2029437 0.9999834
Table 4 Exposure = 200 Carb
contrast estimate SE df t.ratio p.value
2uM PFHpA - Methanol 0.7702069 0.1095562 35 7.0302470 0.0000002
2uM PFOA - Methanol 0.5000210 0.1095562 35 4.5640607 0.0003564
2uM PFPA - Methanol 0.1602322 0.1095562 35 1.4625575 0.6294858
500nM PFHpA - Methanol 0.5584118 0.1095562 35 5.0970370 0.0000718
500nM PFOA - Methanol 0.1867053 0.1095562 35 1.7041968 0.4585908
500nM PFPA - Methanol 0.0081208 0.1095562 35 0.0741242 1.0000000
Table 4 Exposure = 400 Carb
contrast estimate SE df t.ratio p.value
2uM PFHpA - Methanol 0.6018107 0.0713529 35 8.4342812 0.0000000
2uM PFOA - Methanol 0.4107645 0.0713529 35 5.7568001 0.0000097
2uM PFPA - Methanol 0.1844964 0.0713529 35 2.5856880 0.0813462
500nM PFHpA - Methanol 0.6129500 0.0713529 35 8.5903971 0.0000000
500nM PFOA - Methanol 0.2742001 0.0713529 35 3.8428715 0.0029400
500nM PFPA - Methanol 0.0585436 0.0713529 35 0.8204799 0.9609344

[1] 5

  • Sheet 5: Please compare each exposure group to the 1% methanol group at each carboplatin dose
    Table 5 Exposure = 0 Cis
    contrast estimate SE df t.ratio p.value
    2uM PFHpA - Methanol 0.0541766 0.073538 38 0.7367156 0.9875887
    2uM PFOA - Methanol 0.0076818 0.073538 38 0.1044605 1.0000000
    2uM PFPA - Methanol 0.1763144 0.073538 38 2.3975953 0.1412750
    500nM PFHpA - Methanol -0.0618738 0.073538 38 -0.8413848 0.9737219
    500nM PFOA - Methanol -0.0369724 0.073538 38 -0.5027658 0.9988137
    500nM PFPA - Methanol 0.1024935 0.073538 38 1.3937489 0.7320345
    Media - Methanol -0.0130263 0.073538 38 -0.1771373 0.9999990
Table 5 Exposure = 2.5 Cis
contrast estimate SE df t.ratio p.value
2uM PFHpA - Methanol 0.1297890 0.0561419 38 2.3118026 0.1702242
2uM PFOA - Methanol 0.0205974 0.0561419 38 0.3668812 0.9998500
2uM PFPA - Methanol -0.0163200 0.0561419 38 -0.2906926 0.9999688
500nM PFHpA - Methanol 0.0227128 0.0561419 38 0.4045606 0.9997126
500nM PFOA - Methanol -0.1003077 0.0561419 38 -1.7866816 0.4504574
500nM PFPA - Methanol -0.0455663 0.0561419 38 -0.8116282 0.9784633
Media - Methanol 0.0328220 0.0561419 38 0.5846262 0.9969200
Table 5 Exposure = 5 Cis
contrast estimate SE df t.ratio p.value
2uM PFHpA - Methanol 0.0940495 0.0532399 38 1.7665243 0.4644294
2uM PFOA - Methanol 0.0169169 0.0532399 38 0.3177480 0.9999430
2uM PFPA - Methanol -0.0126254 0.0532399 38 -0.2371412 0.9999922
500nM PFHpA - Methanol -0.0233416 0.0532399 38 -0.4384236 0.9995121
500nM PFOA - Methanol -0.0526212 0.0532399 38 -0.9883792 0.9388966
500nM PFPA - Methanol 0.0491481 0.0532399 38 0.9231438 0.9568578
Media - Methanol 0.0158047 0.0532399 38 0.2968590 0.9999640
Table 5 Exposure = 10 Cis
contrast estimate SE df t.ratio p.value
2uM PFHpA - Methanol 0.1626023 0.0878131 38 1.8516858 0.4066412
2uM PFOA - Methanol 0.1593085 0.0878131 38 1.8141759 0.4316807
2uM PFPA - Methanol 0.0295018 0.0878131 38 0.3359611 0.9999169
500nM PFHpA - Methanol 0.1258211 0.0878131 38 1.4328285 0.7051138
500nM PFOA - Methanol 0.0368987 0.0878131 38 0.4201956 0.9996309
500nM PFPA - Methanol 0.0849007 0.0878131 38 0.9668337 0.9452981
Media - Methanol 0.0118741 0.0878131 38 0.1352201 0.9999998
Table 5 Exposure = 25 Cis
contrast estimate SE df t.ratio p.value
2uM PFHpA - Methanol 0.1138165 0.0634084 38 1.7949763 0.4447573
2uM PFOA - Methanol 0.0753372 0.0634084 38 1.1881268 0.8564323
2uM PFPA - Methanol 0.1586497 0.0634084 38 2.5020319 0.1116526
500nM PFHpA - Methanol 0.0161099 0.0634084 38 0.2540659 0.9999876
500nM PFOA - Methanol -0.0343849 0.0634084 38 -0.5422764 0.9980787
500nM PFPA - Methanol 0.0174576 0.0634084 38 0.2753201 0.9999785
Media - Methanol -0.0179337 0.0634084 38 -0.2828283 0.9999741

[1] 6

  • Sheet 6: Please compare each exposure group to the 1% methanol group at each carboplatin dose
    Table 6 Exposure = 0 Carb
    contrast estimate SE df t.ratio p.value
    (1uM PFHpA + 1uM PFPA) - Methanol 0.0998504 0.0727799 37 1.3719509 0.6254934
    (1uM PFOA + 1uM PFHpA) - Methanol 0.0050332 0.0727799 37 0.0691558 0.9999995
    (1uM PFOA + 1uM PFPA) - Methanol 0.0681612 0.0727799 37 0.9365395 0.8884247
    (750nM PFOA + 750nM PFHpA + 750nM PFPA) - Methanol 0.2607945 0.0727799 37 3.5833320 0.0048555
    Media - Methanol 0.0579758 0.0797264 37 0.7271849 0.9588426
Table 6 Exposure = 50 Carb
contrast estimate SE df t.ratio p.value
(1uM PFHpA + 1uM PFPA) - Methanol 0.0734664 0.0742269 37 0.9897545 0.8636958
(1uM PFOA + 1uM PFHpA) - Methanol 0.0442016 0.0742269 37 0.5954929 0.9825771
(1uM PFOA + 1uM PFPA) - Methanol 0.1085532 0.0742269 37 1.4624508 0.5616470
(750nM PFOA + 750nM PFHpA + 750nM PFPA) - Methanol 0.3078203 0.0742269 37 4.1470163 0.0009432
Media - Methanol 0.1277064 0.0813115 37 1.5705815 0.4864852
Table 6 Exposure = 100 Carb
contrast estimate SE df t.ratio p.value
(1uM PFHpA + 1uM PFPA) - Methanol 0.1646657 0.0882540 37 1.865815 0.3043507
(1uM PFOA + 1uM PFHpA) - Methanol 0.1048986 0.0882540 37 1.188599 0.7500479
(1uM PFOA + 1uM PFPA) - Methanol 0.1231202 0.0882540 37 1.395066 0.6092050
(750nM PFOA + 750nM PFHpA + 750nM PFPA) - Methanol 0.3715579 0.0882540 37 4.210096 0.0007816
Media - Methanol 0.1861047 0.0966774 37 1.925007 0.2736476
Table 6 Exposure = 200 Carb
contrast estimate SE df t.ratio p.value
(1uM PFHpA + 1uM PFPA) - Methanol 0.0907620 0.0917956 37 0.9887401 0.8641921
(1uM PFOA + 1uM PFHpA) - Methanol 0.0685259 0.0917956 37 0.7465050 0.9541174
(1uM PFOA + 1uM PFPA) - Methanol 0.0721910 0.0917956 37 0.7864320 0.9432459
(750nM PFOA + 750nM PFHpA + 750nM PFPA) - Methanol 0.2501287 0.0917956 37 2.7248449 0.0478847
Media - Methanol 0.1628927 0.1005570 37 1.6199038 0.4532479
Table 6 Exposure = 400 Carb
contrast estimate SE df t.ratio p.value
(1uM PFHpA + 1uM PFPA) - Methanol 0.1775763 0.0804075 37 2.208454 0.1565924
(1uM PFOA + 1uM PFHpA) - Methanol 0.0785466 0.0804075 37 0.976856 0.8699355
(1uM PFOA + 1uM PFPA) - Methanol 0.1657964 0.0804075 37 2.061952 0.2109833
(750nM PFOA + 750nM PFHpA + 750nM PFPA) - Methanol 0.3013720 0.0804075 37 3.748058 0.0030338
Media - Methanol 0.1584576 0.0880820 37 1.798978 0.3415744

[1] 7

  • Sheet 7: Please compare each exposure group to the 1% methanol group at each carboplatin dose
    Table 7 Exposure = 0 Cis
    contrast estimate SE df t.ratio p.value
    (1uM PFHpA + 1uM PFPA) - Methanol 0.0333483 0.0533770 31 0.6247692 0.9786529
    (1uM PFOA + 1uM PFHpA) - Methanol -0.0264186 0.0590105 31 -0.4476937 0.9952861
    (1uM PFOA + 1uM PFPA) - Methanol 0.0106011 0.0590105 31 0.1796473 0.9999435
    (750nM PFOA + 750nM PFHpA + 750nM PFPA) - Methanol 0.1021687 0.0533770 31 1.9140974 0.2849436
    Media - Methanol -0.0433567 0.0679844 31 -0.6377456 0.9766532
Table 7 Exposure = 2.5 Cis
contrast estimate SE df t.ratio p.value
(1uM PFHpA + 1uM PFPA) - Methanol -0.0374428 0.0509207 31 -0.7353153 0.9572549
(1uM PFOA + 1uM PFHpA) - Methanol -0.0866295 0.0562949 31 -1.5388503 0.5128955
(1uM PFOA + 1uM PFPA) - Methanol -0.0287747 0.0562949 31 -0.5111411 0.9913051
(750nM PFOA + 750nM PFHpA + 750nM PFPA) - Methanol 0.0566630 0.0509207 31 1.1127697 0.7988132
Media - Methanol 0.0834511 0.0648559 31 1.2867156 0.6878274
Table 7 Exposure = 5 Cis
contrast estimate SE df t.ratio p.value
(1uM PFHpA + 1uM PFPA) - Methanol -0.0253251 0.0435014 31 -0.5821673 0.9843642
(1uM PFOA + 1uM PFHpA) - Methanol -0.0612163 0.0480926 31 -1.2728861 0.6971751
(1uM PFOA + 1uM PFPA) - Methanol -0.0333510 0.0480926 31 -0.6934744 0.9665584
(750nM PFOA + 750nM PFHpA + 750nM PFPA) - Methanol 0.0900275 0.0435014 31 2.0695328 0.2135858
Media - Methanol -0.1063533 0.0554061 31 -1.9195212 0.2822049
Table 7 Exposure = 10 Cis
contrast estimate SE df t.ratio p.value
(1uM PFHpA + 1uM PFPA) - Methanol -0.0741818 0.0675668 31 -1.0979033 0.8074490
(1uM PFOA + 1uM PFHpA) - Methanol -0.1081974 0.0746979 31 -1.4484659 0.5755951
(1uM PFOA + 1uM PFPA) - Methanol -0.1037566 0.0746979 31 -1.3890160 0.6171845
(750nM PFOA + 750nM PFHpA + 750nM PFPA) - Methanol -0.0528756 0.0675668 31 -0.7825678 0.9448374
Media - Methanol -0.1239285 0.0860575 31 -1.4400674 0.5814688
Table 7 Exposure = 25 Cis
contrast estimate SE df t.ratio p.value
(1uM PFHpA + 1uM PFPA) - Methanol -0.0854829 0.0575676 27 -1.4849125 0.5540709
(1uM PFOA + 1uM PFHpA) - Methanol -0.0501070 0.0575676 27 -0.8704019 0.9167476
(1uM PFOA + 1uM PFPA) - Methanol -0.0977714 0.0575676 27 -1.6983747 0.4125686
(750nM PFOA + 750nM PFHpA + 750nM PFPA) - Methanol 0.0073326 0.0575676 27 0.1273746 0.9999898
Media - Methanol -0.1001620 0.0656372 27 -1.5259953 0.5258447

[1] 8

  • Sheet 8: Please compare each exposure group to the 1% methanol group (do you mean 0uM Carboplatin?)
    Table 8
    contrast estimate SE df t.ratio p.value
    0uM Carboplatin - 100uM Carboplatin 0.5625346 0.0325893 77 17.26131 0
    0uM Carboplatin - 100uM CCCP 0.7880959 0.0316711 77 24.88373 0
    0uM Carboplatin - 200uM Carboplatin 0.5080574 0.0325893 77 15.58969 0
    0uM Carboplatin - 400uM Carboplatin 0.4451535 0.0325893 77 13.65949 0
    0uM Carboplatin - 50uM Carboplatin 0.5946873 0.0325893 77 18.24792 0

[1] 9

  • Sheet 9: Please compare each exposure group to the 1% methanol group (do you mean 0uM Cisplatin?)
    Table 9
    contrast estimate SE df t.ratio p.value
    0uM Cisplatin - 100uM CCCP 0.7848335 0.0347231 69 22.602642 0
    0uM Cisplatin - 10uM Cisplatin 0.3543405 0.0372886 69 9.502647 0
    0uM Cisplatin - 2.5uM Cisplatin 0.3854214 0.0364117 69 10.585085 0
    0uM Cisplatin - 25uM Cisplatin 0.3770220 0.0383910 69 9.820578 0
    0uM Cisplatin - 5uM Cisplatin 0.3318506 0.0374144 69 8.869605 0

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