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Identification of p53 Activators in a Human Microarray Compendium with Significant Biomarker Correlation

Biomarkers predictive of molecular and toxicological effects are needed to interpret emerging high-throughput transcriptomic data streams. The TGx-DDI biomarker was compared to microarray data in a compendium derived from human cells using the Running Fisher test, a nonparametric correlation test. This dataset contains 274 biosets with a significant TGx-DDI biomarker correlation.

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Bioset Name Chemical Tier Time of Treatment (hrs) Concentration Study Biosource Biomarker (-log(p-value)) Possible Mechanism Comments References (PubMed ID)