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The DNTP Technical Report (TR) Level of Evidence Criteria are available here: https://ntp.niehs.nih.gov/go/baresults. In the table below this information is further delineated into three fields:

  • Level of Evidence: The overall category of evidence of carcinogenic activity for the TR, Species, Strain and Sex
  • Organ Site Call: The level of evidence supported by the specific organ site for the TR, Species, Strain and Sex. When the Organ Site Call directly supports the TR Level Of Evidence the Finding Type flag is set to “Neoplastic Lesion”. Some Organ Site Calls could support a separate call of Equivocal Evidence; this is noted in Finding Type by the flag “May Have Been Related”
  • Finding Type: Further identification of the Organ Site Call. Where this says “Neoplastic Lesion” the Organ Site Call supports the TR Level of Evidence and the Organ Site Call is the same as that of the TR. Where Finding Type says “May Have Been Related” the TR Level of Evidence for other responses led to an overall call of Clear or Some Evidence but the specified organ supports a call of Equivocal Evidence.
View results
  • Organ: Adrenal Gland Medulla
  • Level of Evidence: Positive, Clear Evidence, Some Evidence
Displays results that match exactly with the given criteria.
Exact Match Publication No. CASRN Test Article Name Species Strain Sex Route Organ Level of Evidence Organ Site Call Tumor Type/Incidence Finding Type
Yes TR-074 79-00-5 1,1,2-Trichloroethane Mice B6C3F1 Female Gavage Adrenal Gland Medulla Positive Positive PHEOCHROMOCYTOMA Neoplastic Lesions
Yes TR-074 79-00-5 1,1,2-Trichloroethane Mice B6C3F1 Male Gavage Adrenal Gland Medulla Positive Positive PHEOCHROMOCYTOMA Neoplastic Lesions
Yes TR-085 5131-60-2 4-Chloro-m-phenylenediamine Rats F344/N Male Dosed-Feed Adrenal Gland Medulla Positive Positive PHEOCHROMOCYTOMA Neoplastic Lesions
Yes TR-193 50-55-5 Reserpine Rats F344/N Male Dosed-Feed Adrenal Gland Medulla Positive Positive PHEOCHROMOCYTOMA Neoplastic Lesions
Yes TR-248 13552-44-8 4,4'-Methylenedianiline dihydrochloride Mice B6C3F1 Male Dosed-Water Adrenal Gland Medulla Positive Positive PHEOCHROMOCYTOMA 2/48 12/49 14/49 Neoplastic Lesions
Yes TR-285 569-61-9 C.I. Basic Red 9 Monohydrochloride Mice B6C3F1 Female Dosed-Feed Adrenal Gland Medulla Clear Evidence Clear Evidence PHEOCHROMOCYTOMA 1/48 7/47 7/45 OR MALIGNANT PHEOCHROMOCYTOMA 0/48 1/47 1/45 COMBINED 1/48 8/47 8/45 Neoplastic Lesions
Yes TR-332 149-30-4 2-Mercaptobenzothiazole Rats F344/N Female Gavage Adrenal Gland Medulla Some Evidence Some Evidence PHEOCHROMOCYTOMA 1/50 5/50 6/50 Neoplastic Lesions
Yes TR-414 1825-21-4 Pentachloroanisole Rats F344/N Male Gavage Adrenal Gland Medulla Some Evidence Some Evidence Pheochromocytoma 12/50 17/50 23/50 15/48 or malignant pheochromocytoma 3/50 2/50 4/50 0/48 combined 15/50 18/50 25/50 15/48 Neoplastic Lesions
Yes TR-405 6459-94-5 C.I. Acid Red 114 Rats F344/N Male Dosed-Water Adrenal Gland Medulla Clear Evidence Equivocal Evidence PHEOCHROMOCYTOMA 16/50 11/35 24/63 19/49 OR MALIGNANT PHEOCHROMOCYTOMA 2/50 0/35 3/63 2/49 COMBINED 17/50 11/35 27/63 21/49 May Have Been Related
Yes TR-351 20265-96-7 p-Chloroaniline hydrochloride Rats F344/N Male Gavage Adrenal Gland Medulla Clear Evidence Equivocal Evidence PHEOCHROMOCYTOMA 13/49 14/48 15/48 26/49 May Have Been Related
Yes TR-332 149-30-4 2-Mercaptobenzothiazole Rats F344/N Male Gavage Adrenal Gland Medulla Some Evidence Some Evidence PHEOCHROMOCYTOMA 18/50 25/50 22/49 OR MALIGNANT PHEOCHROMOCYTOMA 0/50 2/50 2/49 COMBINED 18/50 27/50 24/49 Neoplastic Lesions
Yes TR-421 14807-96-6 Talc Rats F344/N Female Inhalation Adrenal Gland Medulla Clear Evidence Clear Evidence PHEOCHROMOCYTOMA 13/48 14/47 18/49 OR MALIGNANT PHEOCHROMOCYTOMA 0/48 1/47 10/49 COMBINED 13/48 14/47 23/49 Neoplastic Lesions
Yes TR-405 6459-94-5 C.I. Acid Red 114 Rats F344/N Female Dosed-Water Adrenal Gland Medulla Clear Evidence Equivocal Evidence PHEOCHROMOCYTOMA 1/50 3/35 5/64 1/50 May Have Been Related
Yes TR-361 67-72-1 Hexachloroethane Rats F344/N Male Gavage Adrenal Gland Medulla Clear Evidence Equivocal Evidence PHEOCHROMOCYTOMA 15/50 28/45 21/49 May Have Been Related
Yes TR-407 2425-85-6 C.I. Pigment Red 3 Rats F344/N Male Dosed-Feed Adrenal Gland Medulla Some Evidence Some Evidence PHEOCHROMOCYTOMA 24/50 32/50 37/50 36/50 Neoplastic Lesions
Yes TR-402 110-00-9 Furan Mice B6C3F1 Female Gavage Adrenal Gland Medulla Clear Evidence Clear Evidence PHEOCHROMOCYTOMA 2/50 1/50 6/50 Neoplastic Lesions
Yes TR-402 110-00-9 Furan Mice B6C3F1 Male Gavage Adrenal Gland Medulla Clear Evidence Clear Evidence PHEOCHROMOCYTOMA 1/49 6/50 10/50 Neoplastic Lesions
Yes TR-363 74-96-4 Bromoethane (ethyl bromide) Rats F344/N Male Inhalation Adrenal Gland Medulla Some Evidence Some Evidence PHEOCHROMOCYTOMA 8/48 23/47 17/50 21/49 OR MALIGNANT PHEOCHROMOCYTOMA 0/48 1/47 2/50 0/49 COMBINED 8/48 23/47 18/50 21/49 Neoplastic Lesions
Yes TR-313 2385-85-5 Mirex Rats F344/N Male Dosed-Feed Adrenal Gland Medulla Clear Evidence Clear Evidence PHEOCHROMOCYTOMA 8/51 7/52 13/52 11/52 18/51 19/51 Neoplastic Lesions
Yes TR-421 14807-96-6 Talc Rats F344/N Male Inhalation Adrenal Gland Medulla Some Evidence Some Evidence PHEOCHROMOCYTOMA 25/49 30/48 36/47 OR MALIGNANT PHEOCHROMOCYTOMA 3/49 3/48 7/47 COMBINED 26/49 32/48 37/47 Neoplastic Lesions
Yes TR-349 87-86-5 Pentachlorophenol, Dowicide EC-7 Mice B6C3F1 Female Dosed-Feed Adrenal Gland Medulla Clear Evidence Clear Evidence PHEOCHROMOCYTOMA 0/35 2/49 2/46 38/49 Neoplastic Lesions
Yes TR-349 87-86-5 Pentachlorophenol, Dowicide EC-7 Mice B6C3F1 Male Dosed-Feed Adrenal Gland Medulla Clear Evidence Clear Evidence PHEOCHROMOCYTOMA 0/34 4/48 21/48 44/49 OR MALIGNANT PHEOCHROMOCYTOMA 1/34 0/48 0/48 3/49 COMBINED 1/34 4/48 21/48 45/49 Neoplastic Lesions
Yes TR-414 1825-21-4 Pentachloroanisole Mice B6C3F1 Male Gavage Adrenal Gland Medulla Some Evidence Some Evidence Pheochromocytoma 0/50 4/50 7/48 Neoplastic Lesions
Yes TR-349 87-86-5 Pentachlorophenol, technical Mice B6C3F1 Male Dosed-Feed Adrenal Gland Medulla Clear Evidence Clear Evidence PHEOCHROMOCYTOMA 0/31 10/45 23/45 Neoplastic Lesions
Yes TR-499 22398-80-7 Indium phosphide Rats F344/N Male Inhalation Adrenal Gland Medulla Clear Evidence Clear Evidence BENIGN PHEOCHROMOCYTOMA 10/50 22/50 16/49 23/50 BENIGN OR MALIGNANT PHEOCHROMOCYTOMA 10/50 26/50 18/49 24/50 Neoplastic Lesions
Yes TR-492 1303-00-0 Gallium arsenide Rats F344/N Female Inhalation Adrenal Gland Medulla Clear Evidence Clear Evidence BENIGN PHEOCHROMOCYTOMA 4/50 5/49 6/50 13/49 Neoplastic Lesions
Yes TR-519 64742-88-7 Stoddard solvent (type lIC) Rats F344/N Male Inhalation Adrenal Gland Medulla Some Evidence Some Evidence BENIGN PHEOCHROMOCYTOMA 5/50 9/50 13/50 17/50 BENIGN OR MALIGNANT PHEOCHROMOCYTOMA 6/50 9/50 13/50 19/50 Neoplastic Lesions
Yes TR-453 12035-72-2 Nickel subsulfide Rats F344/N Female Inhalation Adrenal Gland Medulla Clear Evidence Clear Evidence PHEOCHROMOCYTOMA 2/53 7/53 36/53 Neoplastic Lesions
Yes TR-465 77-09-8 Phenolphthalein Rats F344/N Female Dosed-Feed Adrenal Gland Medulla Some Evidence Some Evidence PHEOCHROMOCYTOMA 3/50 11/50 9/50 2/49 OR MALIGNANT PHEOCHROMOCYTOMA 0/50 1/50 1/50 0/50 COMBINED 3/50 12/50 10/50 2/49 Neoplastic Lesions
Yes TR-465 77-09-8 Phenolphthalein Rats F344/N Male Dosed-Feed Adrenal Gland Medulla Clear Evidence Clear Evidence PHEOCHROMOCYTOMA 17/50 34/50 34/50 34/50 Neoplastic Lesions
Yes TR-451 1313-99-1 Nickel (II) oxide Rats F344/N Female Inhalation Adrenal Gland Medulla Some Evidence Some Evidence PHEOCHROMOCYTOMA 4/51 7/52 6/53 18/53 Neoplastic Lesions
Yes TR-453 12035-72-2 Nickel subsulfide Rats F344/N Male Inhalation Adrenal Gland Medulla Clear Evidence Clear Evidence PHEOCHROMOCYTOMA 13/53 30/52 38/53 OR MALIGNANT PHEOCHROMOCYTOMA 0/53 2/52 10/53 COMBINED 14/53 30/52 38/53 Neoplastic Lesions
Yes TR-513 91-17-8 Decalin Rats F344/N Male Inhalation Adrenal Gland Medulla Clear Evidence Clear Evidence BENIGN OR MALIGNANT PHEOCHROMOCYTOMA 8/49 9/49 13/49 16/49 8/20 Neoplastic Lesions
Yes TR-499 22398-80-7 Indium phosphide Rats F344/N Female Inhalation Adrenal Gland Medulla Clear Evidence Clear Evidence BENIGN PHEOCHROMOCYTOMA 2/50 6/48 2/50 9/49 Neoplastic Lesions
Yes TR-451 1313-99-1 Nickel (II) oxide Rats F344/N Male Inhalation Adrenal Gland Medulla Some Evidence Some Evidence PHEOCHROMOCYTOMA 27/54 24/52 26/53 32/52 OR MALIGNANT PHEOCHROMOCYTOMA 0/54 0/52 1/53 6/52 COMBINED 27/54 24/52 27/53 35/52 Neoplastic Lesions
Yes TR-471 10026-24-1 Cobalt sulfate heptahydrate Rats F344/N Female Inhalation Adrenal Gland Medulla Clear Evidence Clear Evidence BENIGN PHEOCHROMOCYTOMA 2/48 1/49 3/50 8/48, MALIGNANT PHEOCHROMOCYTOMA 0/48 0/49 1/50 1/48 OR COMPLEX PHEOCHROMOCYTOMA 0/48 0/49 0/50 1/48 COMBINED 2/48 1/49 4/50 10/48 Neoplastic Lesions
Yes TR-471 10026-24-1 Cobalt sulfate heptahydrate Rats F344/N Male Inhalation Adrenal Gland Medulla Some Evidence Equivocal Evidence BENIGN PHEOCHROMOCYTOMA 14/50 19/50 23/49 20/50, MALIGNANT PHEOCHROMOCYTOMA 0/50 2/50 2/49 2/50, OR COMPLEX PHEOCHROMOCYTOMA 1/50 0/50 1/49 0/50 COMBINED 15/50 19/50 25/49 20/50 May Have Been Related
Yes TR-595 CELLPRADGSM Cell Phone Radiation: GSM Rats Hsd:Sprague Dawley SD Male Whole Body Exposure Adrenal Gland Medulla Clear Evidence Clear Evidence benign, malignant, or complex pheochromocytoma (11/88, 24/90, 28/89, 14/87) Neoplastic Lesions
Yes TR-581 7440-48-4 Cobalt Rats F344/NTac Female Inhalation Adrenal Gland Medulla Clear Evidence Clear Evidence benign pheochromocytoma 6/50 12/50 22/50 36/50 malignant pheochromocytoma 0/50 2/50 3/50 11/50 benign or malignant pheochromocytoma 6/50 13/50 23/50 40/50 Neoplastic Lesions
Yes TR-581 7440-48-4 Cobalt Rats F344/NTac Male Inhalation Adrenal Gland Medulla Clear Evidence Clear Evidence benign pheochromocytoma 15/50 23/50 37/50 34/50 malignant pheochromocytoma 2/50 2/50 9/50 16/50 benign or malignant pheochromocytoma 17/50 23/50 38/50 41/50 Neoplastic Lesions
Yes TR-590 1309-64-4 Antimony Trioxide Rats Wistar Han Female Inhalation Adrenal Gland Medulla Some Evidence Some Evidence benign pheochromocytoma (0/49, 2/49, 2/49, 6/50); benign or malignant pheochromocytoma (0/49, 2/49, 2/49, 7/50) Neoplastic Lesions
Yes TR-590 1309-64-4 Antimony Trioxide Rats Wistar Han Male Inhalation Adrenal Gland Medulla Some Evidence Some Evidence benign pheochromocytoma (1/49, 0/50, 2/49, 7/50) Neoplastic Lesions
Yes TR-594 98-56-6 p-Chloro-a,a,a-trifluorotoluene Rats Harlan Sprague-Dawley Female Inhalation Adrenal Gland Medulla Some Evidence Some Evidence benign pheochromocytoma (0/49, 3/50, 4/50, 6/50) Neoplastic Lesions
Yes TR-570 76231-76-0 alpha/beta Thujone mixture Rats F344/N Male Gavage Adrenal Gland Medulla Some Evidence Equivocal Evidence Benign pheochromocytoma 6/50 850 12/49 May Have Been Related
Yes TR-319 106-46-7 1,4-Dichlorobenzene (p-dichlorobenzene) Mice B6C3F1 Male Gavage Adrenal Gland Medulla Clear Evidence Equivocal Evidence PHEOCHROMOCYTOMA 0/47 2/48 4/49 May Have Been Related