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The DNTP Technical Report (TR) Level of Evidence Criteria are available here: https://ntp.niehs.nih.gov/go/baresults. In the table below this information is further delineated into three fields:

  • Level of Evidence: The overall category of evidence of carcinogenic activity for the TR, Species, Strain and Sex
  • Organ Site Call: The level of evidence supported by the specific organ site for the TR, Species, Strain and Sex. When the Organ Site Call directly supports the TR Level Of Evidence the Finding Type flag is set to “Neoplastic Lesion”. Some Organ Site Calls could support a separate call of Equivocal Evidence; this is noted in Finding Type by the flag “May Have Been Related”
  • Finding Type: Further identification of the Organ Site Call. Where this says “Neoplastic Lesion” the Organ Site Call supports the TR Level of Evidence and the Organ Site Call is the same as that of the TR. Where Finding Type says “May Have Been Related” the TR Level of Evidence for other responses led to an overall call of Clear or Some Evidence but the specified organ supports a call of Equivocal Evidence.
View results
  • Organ: Brain
  • Level of Evidence: Positive, Clear Evidence, Some Evidence
Displays results that match exactly with the given criteria.
Exact Match Publication No. CASRN Test Article Name Species Strain Sex Route Organ Level of Evidence Organ Site Call Tumor Type/Incidence Finding Type
Yes TR-019 366-70-1 Procarbazine hydrochloride Mice B6C3F1 Male Intraperitoneal Injection Brain Positive Positive (NEUROBLASTOMA) Neoplastic Lesions
Yes TR-019 366-70-1 Procarbazine hydrochloride Rats Sprague Dawley Female Intraperitoneal Injection Brain Positive Positive (NEUROBLASTOMA) Neoplastic Lesions
Yes TR-019 366-70-1 Procarbazine hydrochloride Rats Sprague Dawley Male Intraperitoneal Injection Brain Positive Positive (ADENOCARCINOMA, NEUROBLASTOMA, CARCINOMA) Neoplastic Lesions
Yes TR-019 366-70-1 Procarbazine hydrochloride Mice B6C3F1 Female Intraperitoneal Injection Brain Positive Positive (NEUROBLASTOMA) Neoplastic Lesions
Yes TR-288 106-99-0 1,3-Butadiene Mice B6C3F1 Male Inhalation Brain Clear Evidence Equivocal Evidence GLIOMA 0/50 2/48 1/49 May Have Been Related
Yes TR-434 106-99-0 1,3-Butadiene Mice B6C3F1 Male Inhalation Brain Clear Evidence Clear Evidence (STOP STUDY) GLIOMA 0/50 2/50 0/50 1/50 Neoplastic Lesions
Yes TR-390 612-82-8 3,3'-Dimethylbenzidine dihydrochloride Rats F344/N Female Dosed-Water Brain Clear Evidence Equivocal Evidence ASTROCYTOMA 0/60 1/45 1/75 0/60; GLIOMA 0/60 0/45 1/75 1/60; MENINGIOMA 0/60 1/45 0/75 0/60 May Have Been Related
Yes TR-374 556-52-5 Glycidol Rats F344/N Female Gavage Brain Clear Evidence Clear Evidence GLIOMA 0/50 4/50 4/50 Neoplastic Lesions
Yes TR-390 612-82-8 3,3'-Dimethylbenzidine dihydrochloride Rats F344/N Male Dosed-Water Brain Clear Evidence Equivocal Evidence GLIOMA 0/60 0/45 1/75 1/60; MENINGIOMA 0/60 0/45 0/75 1/60; MENINGEAL SARCOMA 0/60 0/45 1/75 0/60 May Have Been Related
Yes TR-374 556-52-5 Glycidol Rats F344/N Male Gavage Brain Clear Evidence Clear Evidence GLIOMA 0/50 5/50 6/50 Neoplastic Lesions
Yes TR-363 74-96-4 Bromoethane (ethyl bromide) Rats F344/N Male Inhalation Brain Some Evidence Equivocal Evidence GRANULAR CELL TUMOR 0/49 3/50 1/50 1/50; GLIOMA 0/49 1/50 0/50 0/50, ASTROCYTOMA 0/49 1/50 0/50 0/50, OR OLIGODENDROGLIOMA 0/49 1/50 0/50 0/50 COMBINED 0/49 3/50 0/50 0/50 May Have Been Related
Yes TR-397 2429-74-5 C.I. Direct Blue 15 Rats F344/N Male Dosed-Water Brain Clear Evidence Equivocal Evidence ASTROCYTOMA 0/50 1/35 1/65 2/50 May Have Been Related
Yes TR-372 20325-40-0 3,3'-Dimethoxybenzidine dihydrochloride Rats F344/N Male Dosed-Water Brain Clear Evidence Equivocal Evidence ASTROCYTOMA 0/60 2/44 3/75 1/60 May Have Been Related
Yes TR-486 78-79-5 Isoprene Rats F344/N Female Inhalation Brain Some Evidence Equivocal Evidence ASTROCYTOMA 0/50 0/50 1/50 0/50, GLIOMA 0/50 0/50 0/50 1/50, MEDULOBLASTOMA 0/50 0/50 0/50 1/50, MENINGEAL GRANULAR CELL TUMOR 0/50 1/50 0/50 1/50, MENINGEAL SARCOMA 0/50 1/50 0/50 1/50 May Have Been Related
Yes TR-595 CELLPRADGSM Cell Phone Radiation: GSM Rats Hsd:Sprague Dawley SD Male Whole Body Exposure Brain Clear Evidence Equivocal Evidence meninges, granular cell tumor benign or malignant (1/90, 3/90, 4/90, 3/90) May Have Been Related
Yes TR-595 CELLPRADGSM Cell Phone Radiation: GSM Rats Hsd:Sprague Dawley SD Male Whole Body Exposure Brain Clear Evidence Clear Evidence glioma malignant (0/90, 3/90, 3/90, 2/90) Neoplastic Lesions
Yes TR-583 71133-14-7 Water disinfection byproducts (Bromodichloroacetic Acid) Rats F344/NTac Female Dosed-Water Brain Clear Evidence Equivocal Evidence glioma or oligodendroglioma (original and extended evaluations combined): 0/50 1/50 3/50 1/50 May Have Been Related
Yes TR-583 71133-14-7 Water disinfection byproducts (Bromodichloroacetic Acid) Rats F344/NTac Male Dosed-Water Brain Clear Evidence Equivocal Evidence glioma or oligodendroglioma (original and extended evaluations combined): 0/50 1/50 4/50 3/50 May Have Been Related
Yes TR-595 CELLPRADCDMA Cell Phone Radiation: CDMA Rats Hsd:Sprague Dawley SD Male Whole Body Exposure Brain Clear Evidence Clear Evidence glioma malignant (0/90, 0/90, 0/90, 3/90) Neoplastic Lesions