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The DNTP Technical Report (TR) Level of Evidence Criteria are available here: https://ntp.niehs.nih.gov/go/baresults. In the table below this information is further delineated into three fields:

  • Level of Evidence: The overall category of evidence of carcinogenic activity for the TR, Species, Strain and Sex
  • Organ Site Call: The level of evidence supported by the specific organ site for the TR, Species, Strain and Sex. When the Organ Site Call directly supports the TR Level Of Evidence the Finding Type flag is set to “Neoplastic Lesion”. Some Organ Site Calls could support a separate call of Equivocal Evidence; this is noted in Finding Type by the flag “May Have Been Related”
  • Finding Type: Further identification of the Organ Site Call. Where this says “Neoplastic Lesion” the Organ Site Call supports the TR Level of Evidence and the Organ Site Call is the same as that of the TR. Where Finding Type says “May Have Been Related” the TR Level of Evidence for other responses led to an overall call of Clear or Some Evidence but the specified organ supports a call of Equivocal Evidence.
View results
  • Organ: Clitoral Gland
  • Level of Evidence: Positive, Clear Evidence, Some Evidence
Displays results that match exactly with the given criteria.
Exact Match Publication No. CASRN Test Article Name Species Strain Sex Route Organ Level of Evidence Organ Site Call Tumor Type/Incidence Finding Type
Yes TR-084 39156-41-7 2,4-Diaminoanisole sulfate Rats F344/N Female Dosed-Feed Clitoral Gland Positive Positive (ADENOMA OR CARCINOMA) Neoplastic Lesions
Yes TR-118 602-87-9 5-Nitroacenaphthene Rats F344/N Female Dosed-Feed Clitoral Gland Positive Positive (CARCINOMA) Neoplastic Lesions
Yes TR-127 99-59-2 5-Nitro-o-anisidine Rats F344/N Female Dosed-Feed Clitoral Gland Positive Positive (ADENOMA, CARCINOMA) Neoplastic Lesions
Yes TR-143 2243-62-1 1,5-Naphthalenediamine Rats F344/N Female Dosed-Feed Clitoral Gland Positive Positive (ADENOMA OR CARCINOMA) Neoplastic Lesions
Yes TR-400 96-13-9 2,3-Dibromo-1-propanol Rats F344/N Female Topical Application Clitoral Gland Clear Evidence Clear Evidence ADENOMA 0/50 1/50 3/50 OR ADENOCARCINOMA 0/50 0/50 3/50 COMBINED 0/50 1/50 6/50 Neoplastic Lesions
Yes TR-368 389-08-2 Nalidixic acid Rats F344/N Female Dosed-Feed Clitoral Gland Clear Evidence Clear Evidence ADENOMA 4/46 10/46 11/47, PAPILLOMA 0/46 1/46 0/47, OR CARCINOMA 1/46 4/46 5/47 COMBINED 5/46 15/46 16/47 Neoplastic Lesions
Yes TR-405 6459-94-5 C.I. Acid Red 114 Rats F344/N Female Dosed-Water Clitoral Gland Clear Evidence Clear Evidence ADENOMA 7/48 10/32 10/62 10/50, CARCINOMA 4/48 9/32 19/62 15/50, COMBINED 11/48 17/32 28/62 23/50 Neoplastic Lesions
Yes TR-390 612-82-8 3,3'-Dimethylbenzidine dihydrochloride Rats F344/N Female Dosed-Water Clitoral Gland Clear Evidence Clear Evidence ADENOMA 0/60 9/45 32/75 17/59 OR CARCINOMA 0/60 5/45 11/75 18/59 COMBINED 0/60 14/45 42/75 32/59 Neoplastic Lesions
Yes TR-397 2429-74-5 C.I. Direct Blue 15 Rats F344/N Female Dosed-Water Clitoral Gland Clear Evidence Clear Evidence ADENOMA 5/50 5/31 12/64 12/50, CARCINOMA 2/50 6/31 12/64 15/50, COMBINED 7/50 11/31 24/64 27/50 Neoplastic Lesions
Yes TR-374 556-52-5 Glycidol Rats F344/N Female Gavage Clitoral Gland Clear Evidence Clear Evidence ADENOMA 3/50 7/50 7/50, ADENOCARCINOMA 0/50 1/50 0/50, OR CARCINOMA 2/50 1/50 5/50 COMBINED 5/50 9/50 12/50 Neoplastic Lesions
Yes TR-384 96-18-4 1,2,3-Trichloropropane Rats F344/N Female Gavage Clitoral Gland Clear Evidence Clear Evidence ADENOMA 5/46 10/46 13/50 10/51 OR CARCINOMA 0/46 0/46 4/50 6/51 COMBINED 5/46 10/46 17/50 15/51 Neoplastic Lesions
Yes TR-372 20325-40-0 3,3'-Dimethoxybenzidine dihydrochloride Rats F344/N Female Dosed-Water Clitoral Gland Clear Evidence Clear Evidence ADENOMA 5/58 15/44 13/74 16/55; CARCINOMA 2/58 17/44 41/74 30/55 Neoplastic Lesions
Yes TR-498 99-99-0 p-Nitrotoluene Rats F344/N Female Dosed-Feed Clitoral Gland Some Evidence Some Evidence ADENOMA OR CARCINOMA 8/50 12/50 20/50 8/49 Neoplastic Lesions
Yes TR-442 62-23-7 p-Nitrobenzoic acid Rats F344/N Female Dosed-Feed Clitoral Gland Some Evidence Some Evidence ADENOMA 4/50 12/49 10/49 12/50 OR CARCINOMA 1/50 2/49 5/49 4/50 COMBINED 4/50 14/49 15/49 15/50 Neoplastic Lesions
Yes TR-575 79-06-1 Acrylamide Rats F344 (NCTR) Female Dosed-Water Clitoral Gland Clear Evidence Clear Evidence carcinoma 1/4 6/48 12/47 3/48 8/47 Neoplastic Lesions
Yes TR-588 5694-00-8 Glycidamide Rats F344 (NCTR) Female Dosed-Water Clitoral Gland Clear Evidence Clear Evidence carcinoma 4/48 6/48 7/48 11/48 14/47 Neoplastic Lesions