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The DNTP Technical Report (TR) Level of Evidence Criteria are available here: https://ntp.niehs.nih.gov/go/baresults. In the table below this information is further delineated into three fields:

  • Level of Evidence: The overall category of evidence of carcinogenic activity for the TR, Species, Strain and Sex
  • Organ Site Call: The level of evidence supported by the specific organ site for the TR, Species, Strain and Sex. When the Organ Site Call directly supports the TR Level Of Evidence the Finding Type flag is set to “Neoplastic Lesion”. Some Organ Site Calls could support a separate call of Equivocal Evidence; this is noted in Finding Type by the flag “May Have Been Related”
  • Finding Type: Further identification of the Organ Site Call. Where this says “Neoplastic Lesion” the Organ Site Call supports the TR Level of Evidence and the Organ Site Call is the same as that of the TR. Where Finding Type says “May Have Been Related” the TR Level of Evidence for other responses led to an overall call of Clear or Some Evidence but the specified organ supports a call of Equivocal Evidence.
View results
  • Organ: Forestomach
  • Level of Evidence: Positive, Clear Evidence, Some Evidence
Displays results that match exactly with the given criteria.
Exact Match Publication No. CASRN Test Article Name Species Strain Sex Route Organ Level of Evidence Organ Site Call Tumor Type/Incidence Finding Type
Yes TR-028 96-12-8 1,2-Dibromo-3-chloropropane Mice B6C3F1 Female Gavage Forestomach Positive Positive (SQUAMOUS CELL CARCINOMA) Neoplastic Lesions
Yes TR-028 96-12-8 1,2-Dibromo-3-chloropropane Mice B6C3F1 Male Gavage Forestomach Positive Positive (SQUAMOUS CELL CARCINOMA) Neoplastic Lesions
Yes TR-028 96-12-8 1,2-Dibromo-3-chloropropane Rats Osborne Mendel Female Gavage Forestomach Positive Positive (SQUAMOUS CELL CARCINOMA) Neoplastic Lesions
Yes TR-028 96-12-8 1,2-Dibromo-3-chloropropane Rats Osborne Mendel Male Gavage Forestomach Positive Positive (SQUAMOUS CELL CARCINOMA) Neoplastic Lesions
Yes TR-034 1582-09-8 Trifluralin Mice B6C3F1 Female Dosed-Feed Forestomach Positive Positive (SQUAMOUS CELL CARCINOMA) Neoplastic Lesions
Yes TR-055 107-06-2 1,2-Dichloroethane Rats Osborne Mendel Male Gavage Forestomach Positive Positive (SQUAMOUS CELL CARCINOMA) Neoplastic Lesions
Yes TR-059 22966-79-6 Estradiol mustard Mice B6C3F1 Female Gavage Forestomach Positive Positive (SQUAMOUS CELL CARCINOMA) Neoplastic Lesions
Yes TR-063 95-83-0 4-Chloro-o-phenylenediamine Rats F344/N Female Dosed-Feed Forestomach Positive Positive (SQUAMOUS CELL PAPILLOMA OR SQUAMOUS CELL CARCINOMA) Neoplastic Lesions
Yes TR-063 95-83-0 4-Chloro-o-phenylenediamine Rats F344/N Male Dosed-Feed Forestomach Positive Positive (SQUAMOUS CELL PAPILLOMA OR SQUAMOUS CELL CARCINOMA) Neoplastic Lesions
Yes TR-076 126-72-7 tris(2,3-Dibromopropyl) phosphate Mice B6C3F1 Female Dosed-Feed Forestomach Positive Positive (SQUAMOUS CELL PAPILLOMA, SQUAMOUS CELL CARCINOMA) Neoplastic Lesions
Yes TR-076 126-72-7 tris(2,3-Dibromopropyl) phosphate Mice B6C3F1 Male Dosed-Feed Forestomach Positive Positive (SQUAMOUS CELL PAPILLOMA, SQUAMOUS CELL PAPILLOMA OR CARCINOMA) Neoplastic Lesions
Yes TR-059 22966-79-6 Estradiol mustard Mice B6C3F1 Male Gavage Forestomach Positive Positive (SQUAMOUS CELL CARCINOMA) Neoplastic Lesions
Yes TR-086 106-93-4 1,2-Dibromoethane Mice B6C3F1 Male Gavage Forestomach Positive Positive (SQUAMOUS CELL CARCINOMA) Neoplastic Lesions
Yes TR-086 106-93-4 1,2-Dibromoethane Rats Osborne Mendel Female Gavage Forestomach Positive Positive (SQUAMOUS CELL CARCINOMA) Neoplastic Lesions
Yes TR-086 106-93-4 1,2-Dibromoethane Rats Osborne Mendel Male Gavage Forestomach Positive Positive SQUAMOUS CELL CARCINOMA Neoplastic Lesions
Yes TR-095 6959-48-4 3-Chloromethylpyridine hydrochloride Mice B6C3F1 Female Gavage Forestomach Positive Positive (SQUAMOUS CELL PAPILLOMA OR CARCINOMA) Neoplastic Lesions
Yes TR-095 6959-48-4 3-Chloromethylpyridine hydrochloride Mice B6C3F1 Male Gavage Forestomach Positive Positive (SQUAMOUS CELL PAPILLOMA OR CARCINOMA) Neoplastic Lesions
Yes TR-095 6959-48-4 3-Chloromethylpyridine hydrochloride Rats F344/N Male Gavage Forestomach Positive Positive (SQUAMOUS CELL PAPILLOMA OR CARCINOMA) Neoplastic Lesions
Yes TR-086 106-93-4 1,2-Dibromoethane Mice B6C3F1 Female Gavage Forestomach Positive Positive (SQUAMOUS CELL CARCINOMA) Neoplastic Lesions
Yes TR-100 135-20-6 Cupferron Rats F344/N Female Dosed-Feed Forestomach Positive Positive SQUAMOUS CELL CARCINOMA Neoplastic Lesions
Yes TR-100 135-20-6 Cupferron Rats F344/N Male Dosed-Feed Forestomach Positive Positive SQUAMOUS CELL CARCINOMA Neoplastic Lesions
Yes TR-115 95-06-7 Sulfallate Rats Osborne Mendel Male Dosed-Feed Forestomach Positive Positive (SQUAMOUS CELL PAPILLOMA OR CARCINOMA) Neoplastic Lesions
Yes TR-140 1955-45-9 Pivalolactone Rats F344/N Female Gavage Forestomach Positive Positive (SQUAMOUS CELL PAPILLOMA OR CARCINOMA) Neoplastic Lesions
Yes TR-140 1955-45-9 Pivalolactone Rats F344/N Male Gavage Forestomach Positive Positive (SQUAMOUS CELL PAPILLOMA OR CARCINOMA) Neoplastic Lesions
Yes TR-222 2832-40-8 C.I. Disperse Yellow 3 Rats F344/N Male Dosed-Feed Forestomach Positive Equivocal Evidence SQUAMOUS CELL PAPILLOMA 0/49 1/50 0/50; FIBROSARCOMA 0/49 1/50 0/50; SARCOMA 0/49 0/50 1/50 May Have Been Related
Yes TR-250 140-11-4 Benzyl acetate Mice B6C3F1 Female Gavage Forestomach Some Evidence Some Evidence SQUAMOUS CELL PAPILLOMA 0/50 0/50 4/48 Neoplastic Lesions
Yes TR-250 140-11-4 Benzyl acetate Mice B6C3F1 Male Gavage Forestomach Some Evidence Some Evidence SQUAMOUS CELL PAPILLOMA 3/49 3/48 9/49 OR SQUAMOUS CELL CARCINOMA 1/49 1/48 2/49 COMBINED 4/49 4/48 11/49 Neoplastic Lesions
Yes TR-259 140-88-5 Ethyl acrylate Rats F344/N Female Gavage Forestomach Positive Positive SQUAMOUS CELL PAPILLOMA 1/50 6/50 9/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 2/50 COMBINED 1/50 6/50 11/50 Neoplastic Lesions
Yes TR-259 140-88-5 Ethyl acrylate Rats F344/N Male Gavage Forestomach Positive Positive SQUAMOUS CELL PAPILLOMA 1/50 15/50 29/50 OR SQUAMOUS CELL CARCINOMA 0/50 5/50 12/50 COMBINED 1/50 18/50 36/50 Neoplastic Lesions
Yes TR-239 108-60-1 bis(2-Chloro-1-methylethyl) ether Mice B6C3F1 Female Gavage Forestomach Positive Equivocal Evidence SQUAMOUS CELL PAPILLOMA 0/50 0/49 1/49 OR SQUAMOUS CELL CARCINOMA 0/50 0/49 1/49 COMBINED 0/50 0/49 2/49 May Have Been Related
Yes TR-269 542-75-6 1,3-Dichloropropene (Telone II) Rats F344/N Female Gavage Forestomach Some Evidence Some Evidence SQUAMOUS CELL PAPILLOMA 0/52 2/52 3/52 Neoplastic Lesions
Yes TR-269 542-75-6 1,3-Dichloropropene (Telone II) Rats F344/N Male Gavage Forestomach Clear Evidence Clear Evidence SQUAMOUS CELL PAPILLOMA 1/52 1/52 9/52; SQUAMOUS CELL CARCINOMA 0/52 0/52 4/52 Neoplastic Lesions
Yes TR-257 101-90-6 Diglycidyl resorcinol ether (DGRE) Mice B6C3F1 Female Gavage Forestomach Positive Positive SQUAMOUS CELL PAPILLOMA 0/47 5/49 10/49; SQUAMOUS CELL CARCINOMA 0/47 12/49 23/49 Neoplastic Lesions
Yes TR-257 101-90-6 Diglycidyl resorcinol ether (DGRE) Mice B6C3F1 Male Gavage Forestomach Positive Positive SQUAMOUS CELL PAPILLOMA 0/47 4/49 10/50; SQUAMOUS CELL CARCINOMA 0/47 14/49 25/50 Neoplastic Lesions
Yes TR-257 101-90-6 Diglycidyl resorcinol ether (DGRE) Rats F344/N Female Gavage Forestomach Positive Positive SQUAMOUS CELL PAPILLOMA 0/49 7/50 1/50; SQUAMOUS CELL CARCINOMA 0/49 34/50 3/50 Neoplastic Lesions
Yes TR-257 101-90-6 Diglycidyl resorcinol ether (DGRE) Rats F344/N Male Gavage Forestomach Positive Positive SQUAMOUS CELL PAPILLOMA 0/50 17/50 6/49; SQUAMOUS CELL CARCINOMA 0/50 38/50 4/49 Neoplastic Lesions
Yes TR-259 140-88-5 Ethyl acrylate Mice B6C3F1 Female Gavage Forestomach Positive Positive SQUAMOUS CELL PAPILLOMA 1/50 4/49 5/48 OR SQUAMOUS CELL CARCINOMA 0/50 1/49 2/48 COMBINED 1/50 5/49 7/48 Neoplastic Lesions
Yes TR-259 140-88-5 Ethyl acrylate Mice B6C3F1 Male Gavage Forestomach Positive Positive SQUAMOUS CELL PAPILLOMA 0/48 4/47 9/50 OR SQUAMOUS CELL CARCINOMA 0/48 2/47 5/50 COMBINED 0/48 5/47 12/50 Neoplastic Lesions
Yes TR-269 542-75-6 1,3-Dichloropropene (Telone II) Mice B6C3F1 Female Gavage Forestomach Clear Evidence Clear Evidence SQUAMOUS CELL PAPILLOMA 0/50 1/50 2/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 2/50 COMBINED 0/50 1/50 4/50 Neoplastic Lesions
Yes TR-287 868-85-9 Dimethyl hydrogen phosphite Rats F344/N Male Gavage Forestomach Clear Evidence Clear Evidence SQUAMOUS CELL PAPILLOMA 0/50 1/50 3/50; SQUAMOUS CELL CARCINOMA 0/50 0/50 3/50 Neoplastic Lesions
Yes TR-288 106-99-0 1,3-Butadiene Mice B6C3F1 Female Inhalation Forestomach Clear Evidence Clear Evidence PAPILLOMA 0/49 4/42 10/49 Neoplastic Lesions
Yes TR-288 106-99-0 1,3-Butadiene Mice B6C3F1 Male Inhalation Forestomach Clear Evidence Clear Evidence PAPILLOMA 0/49 5/40 0/44 Neoplastic Lesions
Yes TR-400 96-13-9 2,3-Dibromo-1-propanol Mice B6C3F1 Female Topical Application Forestomach Clear Evidence Clear Evidence SQUAMOUS CELL PAPILLOMA 0/50 12/49 17/50 OR SQUAMOUS CELL CARCINOMA 0/50 7/47 6/50 COMBINED 0/50 18/49 19/50 Neoplastic Lesions
Yes TR-400 96-13-9 2,3-Dibromo-1-propanol Mice B6C3F1 Male Topical Application Forestomach Clear Evidence Clear Evidence SQUAMOUS CELL PAPILLOMA 0/50 12/50 20/50 OR SQUAMOUS CELL CARCINOMA 0/50 2/50 1/49 COMBINED 0/50 14/50 21/49 Neoplastic Lesions
Yes TR-400 96-13-9 2,3-Dibromo-1-propanol Rats F344/N Female Topical Application Forestomach Clear Evidence Clear Evidence SQUAMOUS CELL PAPILLOMA 1/50 3/50 23/50 Neoplastic Lesions
Yes TR-342 62-73-7 Dichlorvos Mice B6C3F1 Female Gavage Forestomach Clear Evidence Clear Evidence SQUAMOUS CELL PAPILLOMA 5/49 6/49 18/50 Neoplastic Lesions
Yes TR-342 62-73-7 Dichlorvos Mice B6C3F1 Male Gavage Forestomach Some Evidence Some Evidence SQUAMOUS CELL PAPILLOMA 1/50 1/50 5/50 Neoplastic Lesions
Yes TR-434 106-99-0 1,3-Butadiene Mice B6C3F1 Male Inhalation Forestomach Clear Evidence Clear Evidence SQUAMOUS CELL PAPILLOMA OR CARCINOMA 1/50 0/50 0/50 1/50 8/50 4/73, STOP STUDY 3/50 7/50 9/50 10/50 Neoplastic Lesions
Yes TR-374 556-52-5 Glycidol Mice B6C3F1 Male Gavage Forestomach Clear Evidence Clear Evidence SQUAMOUS CELL PAPILLOMA 0/50 2/50 9/50 OR SQUAMOUS CELL CARCINOMA 1/50 0/50 1/50 COMBINED 1/50 2/50 10/50 Neoplastic Lesions
Yes TR-378 100-52-7 Benzaldehyde Mice B6C3F1 Female Gavage Forestomach Some Evidence Some Evidence SQUAMOUS CELL PAPILLOMA 0/50 5/50 6/50 Neoplastic Lesions
Yes TR-378 100-52-7 Benzaldehyde Mice B6C3F1 Male Gavage Forestomach Some Evidence Some Evidence SQUAMOUS CELL PAPILLOMA 1/50 2/50 5/50 Neoplastic Lesions
Yes TR-400 96-13-9 2,3-Dibromo-1-propanol Rats F344/N Male Topical Application Forestomach Clear Evidence Clear Evidence SQUAMOUS CELL PAPILLOMA 0/50 1/50 17/50 Neoplastic Lesions
Yes TR-316 513-37-1 Dimethylvinyl chloride (DMVC) Mice B6C3F1 Female Gavage Forestomach Clear Evidence Clear Evidence SQUAMOUS CELL CARCINOMA 0/50 40/47 36/43 Neoplastic Lesions
Yes TR-316 513-37-1 Dimethylvinyl chloride (DMVC) Mice B6C3F1 Male Gavage Forestomach Clear Evidence Clear Evidence SQUAMOUS CELL PAPILLOMA 1/48 3/47 8/44; SQUAMOUS CELL CARCINOMA 0/48 42/47 35/44 Neoplastic Lesions
Yes TR-316 513-37-1 Dimethylvinyl chloride (DMVC) Rats F344/N Female Gavage Forestomach Clear Evidence Clear Evidence SQUAMOUS CELL PAPILLOMA 1/50 4/50 1/49 OR SQUAMOUS CELL CARCINOMA 0/50 5/50 1/49 COMBINED 1/50 9/50 2/49 Neoplastic Lesions
Yes TR-316 513-37-1 Dimethylvinyl chloride (DMVC) Rats F344/N Male Gavage Forestomach Clear Evidence Clear Evidence SQUAMOUS CELL PAPILLOMA 0/49 7/50 0/50; SQUAMOUS CELL CARCINOMA 0/49 7/50 0/50 Neoplastic Lesions
Yes TR-416 91-23-6 o-Nitroanisole Rats F344/N Male Dosed-Feed Forestomach Clear Evidence Equivocal Evidence SQUAMOUS CELL PAPILLOMA O/50 0/50 1/50 1/50; SQUAMOUS CELL CARCINOMA 0/50 0/50 1/50 1/50 May Have Been Related
Yes TR-382 98-01-1 Furfural Mice B6C3F1 Female Gavage Forestomach Some Evidence Equivocal Evidence SQUAMOUS CELL PAPILLOMA 1/50 0/50 1/50 6/50 May Have Been Related
Yes TR-370 271-89-6 Benzofuran Mice B6C3F1 Female Gavage Forestomach Clear Evidence Clear Evidence SQUAMOUS CELL PAPILLOMA 2/50 8/50 5/50 OR SQUAMOUS CELL CARCINOMA 0/50 1/50 1/50 COMBINED 2/50 9/50 5/50 Neoplastic Lesions
Yes TR-370 271-89-6 Benzofuran Mice B6C3F1 Male Gavage Forestomach Clear Evidence Clear Evidence SQUAMOUS CELL PAPILLOMA 2/49 7/39 10/48 OR SQUAMOUS CELL CARCINOMA 0/49 4/39 3/48 COMBINED 2/49 11/39 13/48 Neoplastic Lesions
Yes TR-374 556-52-5 Glycidol Rats F344/N Female Gavage Forestomach Clear Evidence Clear Evidence SQUAMOUS CELL PAPILLOMA 0/50 4/50 8/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 3/50 COMBINED 0/50 4/50 11/50 Neoplastic Lesions
Yes TR-384 96-18-4 1,2,3-Trichloropropane Rats F344/N Male Gavage Forestomach Clear Evidence Clear Evidence SQUAMOUS CELL PAPILLOMA 0/50 29/50 33/49 38/52; SQUAMOUS CELL CARCINOMA 0/50 9/50 27/49 13/52 Neoplastic Lesions
Yes TR-430 28407-37-6 C.I. Direct Blue 218 Rats F344/N Male Dosed-Feed Forestomach Some Evidence Equivocal Evidence SQUAMOUS CELL PAPILLOMA 0/50 0/50 2/50 1/50; SQUAMOUS CELL CARCINOMA 0/50 0/50 1/50 0/50 May Have Been Related
Yes TR-434 106-99-0 1,3-Butadiene Mice B6C3F1 Female Inhalation Forestomach Clear Evidence Clear Evidence SQUAMOUS CELL PAPILLOMA OR CARCINOMA 0/50 0/50 3/50 2/50 4/50 22/80 Neoplastic Lesions
Yes TR-384 96-18-4 1,2,3-Trichloropropane Mice B6C3F1 Male Gavage Forestomach Clear Evidence Clear Evidence SQUAMOUS CELL PAPILLOMA 3/52 28/51 22/54 33/56; SQUAMOUS CELL CARCINOMA 0/52 40/51 50/54 51/56 Neoplastic Lesions
Yes TR-384 96-18-4 1,2,3-Trichloropropane Rats F344/N Female Gavage Forestomach Clear Evidence Clear Evidence SQUAMOUS CELL PAPILLOMA 0/50 13/49 32/51 17/52; SQUAMOUS CELL CARCINOMA 0/50 3/49 9/51 4/52 Neoplastic Lesions
Yes TR-383 81-49-2 1-Amino-2,4-dibromoanthraquinone Mice B6C3F1 Female Dosed-Feed Forestomach Clear Evidence Clear Evidence SQUAMOUS CELL PAPILLOMA 2/50 16/50 27/50; SQUAMOUS CELL CARCINOMA 0/50 12/50 11/50 Neoplastic Lesions
Yes TR-383 81-49-2 1-Amino-2,4-dibromoanthraquinone Mice B6C3F1 Male Dosed-Feed Forestomach Clear Evidence Clear Evidence SQUAMOUS CELL PAPILLOMA 0/50 13/51 16/50; SQUAMOUS CELL CARCINOMA 0/50 12/51 13/50 Neoplastic Lesions
Yes TR-408 7487-94-7 Mercuric chloride Rats F344/N Male Gavage Forestomach Some Evidence Some Evidence SQUAMOUS CELL PAPILLOMA 0/50 3/50 12/50 Neoplastic Lesions
Yes TR-374 556-52-5 Glycidol Rats F344/N Male Gavage Forestomach Clear Evidence Clear Evidence SQUAMOUS CELL PAPILLOMA 0/50 1/50 5/50 OR SQUAMOUS CELL CARCINOMA 1/50 1/50 2/50 COMBINED 1/50 2/50 6/50 Neoplastic Lesions
Yes TR-340 5634-39-9 Iodinated glycerol Mice B6C3F1 Female Gavage Forestomach Some Evidence Equivocal Evidence SQUAMOUS CELL PAPILLOMA 1/49 2/50 5/49 May Have Been Related
Yes TR-416 91-23-6 o-Nitroanisole Rats F344/N Female Dosed-Feed Forestomach Clear Evidence Equivocal Evidence SQUAMOUS CELL PAPILLOMA 0/50 1/50 0/50 1/50 May Have Been Related
Yes TR-422 91-64-5 Coumarin Mice B6C3F1 Female Gavage Forestomach Clear Evidence Equivocal Evidence SQUAMOUS CELL PAPILLOMA 1/52 5/50 2/51 2/51 May Have Been Related
Yes TR-422 91-64-5 Coumarin Mice B6C3F1 Male Gavage Forestomach Some Evidence Equivocal Evidence SQUAMOUS CELL PAPILLOMA 2/50 8/50 2/50 0/51 May Have Been Related
Yes TR-384 96-18-4 1,2,3-Trichloropropane Mice B6C3F1 Female Gavage Forestomach Clear Evidence Clear Evidence SQUAMOUS CELL PAPILLOMA 0/50 23/50 18/51 29/55; SQUAMOUS CELL CARCINOMA 0/50 46/50 49/51 49/55 Neoplastic Lesions
Yes TR-506 107-13-1 Acrylonitrile Mice B6C3F1 Female Gavage Forestomach Clear Evidence Clear Evidence SQUAMOUS CELL PAPILLOMA 3/50 6/50 24/50 19/50 SQUAMOUS CELL CARCINOMA 0/50 1/50 1/50 11/50 COMBINED 3/50 7/50 25/50 29/50 Neoplastic Lesions
Yes TR-491 93-15-2 Methyleugenol Rats F344/N Female Gavage Forestomach Clear Evidence Equivocal Evidence SQUAMOUS CELL PAPILLOMA OR CARCINOMA 0/50 0/50 1/50 3/50 May Have Been Related
Yes TR-467 126-99-8 Chloroprene Mice B6C3F1 Male Inhalation Forestomach Clear Evidence Clear Evidence SQUAMOUS CELL PAPILLOMA 1/50 0/50 2/50 4/50 Neoplastic Lesions
Yes TR-452 3296-90-0 2,2-bis(Bromomethyl)-1,3-propanediol Rats F344/N Male Dosed-Feed Forestomach Clear Evidence Clear Evidence SQUAMOUS CELL PAPILLOMA 0/51 0/53 0/51 1/55 5/60 Neoplastic Lesions
Yes TR-509 142-83-6 2,4-Hexadienal Rats F344/N Female Gavage Forestomach Clear Evidence Clear Evidence SQUAMOUS CELL PAPILLOMA 0/50 1/50 5/50 17/50 Neoplastic Lesions
Yes TR-509 142-83-6 2,4-Hexadienal Rats F344/N Male Gavage Forestomach Clear Evidence Clear Evidence SQUAMOUS CELL PAPILLOMA 0/50 3/50 10/50 29/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 1/50 2/50 COMBINED 0/50 3/50 11/50 29/50 Neoplastic Lesions
Yes TR-467 126-99-8 Chloroprene Mice B6C3F1 Female Inhalation Forestomach Clear Evidence Clear Evidence Squamous Cell Papilloma 0/50 0/50 0/50 4/50 Neoplastic Lesions
Yes TR-510 51-79-6 Urethane Mice MV Male Dosed-Water Forestomach Clear Evidence Clear Evidence SQUAMOUS CELL PAPILLOMA OR SQUAMOUS CELL CARCINOMA 0/46 2/47 3/44 5/45 Neoplastic Lesions
Yes TR-506 107-13-1 Acrylonitrile Mice B6C3F1 Male Gavage Forestomach Clear Evidence Clear Evidence SQUAMOUS CELL PAPILLOMA 3/50 4/50 19/50 25/50; SQUAMOUS CELL CARCINOMA 0/50 0/50 8/50 9/50 COMBINED 3/50 4/50 26/50 32/50 Neoplastic Lesions
Yes TR-300 563-47-3 3-Chloro-2-methylpropene Mice B6C3F1 Female Gavage Forestomach Clear Evidence Clear Evidence SQUAMOUS CELL PAPILLOMA 0/50 15/48 29/44; SQUAMOUS CELL CARCINOMA 0/50 1/48 2/44 Neoplastic Lesions
Yes TR-300 563-47-3 3-Chloro-2-methylpropene Mice B6C3F1 Male Gavage Forestomach Clear Evidence Clear Evidence SQUAMOUS CELL PAPILLOMA 3/49 19/49 30/49; SQUAMOUS CELL CARCINOMA 0/49 5/49 7/49 Neoplastic Lesions
Yes TR-300 563-47-3 3-Chloro-2-methylpropene Rats F344/N Female Gavage Forestomach Clear Evidence Clear Evidence SQUAMOUS CELL PAPILLOMA 1/50 1/50 10/50 Neoplastic Lesions
Yes TR-300 563-47-3 3-Chloro-2-methylpropene Rats F344/N Male Gavage Forestomach Clear Evidence Clear Evidence SQUAMOUS CELL PAPILLOMA 1/50 5/50 30/48; SQUAMOUS CELL CARCINOMA 0/50 0/50 2/48 Neoplastic Lesions
Yes TR-452 3296-90-0 2,2-bis(Bromomethyl)-1,3-propanediol Mice B6C3F1 Female Dosed-Feed Forestomach Clear Evidence Equivocal Evidence SQUAMOUS CELL PAPILLOMA 0/52 1/50 5/51 3/50 May Have Been Related
Yes TR-452 3296-90-0 2,2-bis(Bromomethyl)-1,3-propanediol Mice B6C3F1 Male Dosed-Feed Forestomach Clear Evidence Equivocal Evidence SQUAMOUS CELL PAPILLOMA 0/50 3/51 2/50 2/49 OR SQUAMOUS CELL CARCINOMA 0/50 0/51 1/50 2/49 COMBINED 0/50 3/51 3/50 4/49 May Have Been Related
Yes TR-484 111-76-2 2-Butoxyethanol (ethylene glycol monobutyl ether) Mice B6C3F1 Female Inhalation Forestomach Some Evidence Some Evidence SQUAMOUS CELL PAPILLOMA 0/50 1/50 2/50 5/50 COMBINED 0/50 1/50 2/50 6/50 Neoplastic Lesions
Yes TR-484 111-76-2 2-Butoxyethanol (ethylene glycol monobutyl ether) Mice B6C3F1 Male Inhalation Forestomach Some Evidence Equivocal Evidence SQUAMOUS CELL PAPILLOMA 1/50 1/50 2/49 2/49 May Have Been Related
Yes TR-509 142-83-6 2,4-Hexadienal Mice B6C3F1 Female Gavage Forestomach Clear Evidence Clear Evidence SQUAMOUS CELL PAPILLOMA 2/50 2/49 11/50 13/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/49 0/50 7/50 COMBINED 2/50 2/49 11/50 18/50 Neoplastic Lesions
Yes TR-509 142-83-6 2,4-Hexadienal Mice B6C3F1 Male Gavage Forestomach Clear Evidence Clear Evidence SQUAMOUS CELL PAPILLOMA 2/50 4/50 5/50 8/50 OR SQUAMOUS CELL CARCINOMA 0/50 1/50 0/50 2/50 COMBINED 2/50 4/50 5/50 10/50 Neoplastic Lesions
Yes TR-558 14047-09-7 3,3',4,4'-Tetrachloroazobenzene Rats Harlan Sprague-Dawley Female Gavage Forestomach Clear Evidence Clear Evidence Squamous cell papilloma or carcinoma 0/50 1/50 0/50 4/50 Neoplastic Lesions
Yes TR-588 5694-00-8 Glycidamide Mice MV Female Dosed-Water Forestomach Clear Evidence Clear Evidence squamous cell papilloma 1/45 1/45 1/47 5/45 9/44 Neoplastic Lesions
Yes TR-575 79-06-1 Acrylamide Mice MV Female Dosed-Water Forestomach Clear Evidence Clear Evidence squamous cell papilloma 4/46 0/46 2/48 5/45 8/42 Neoplastic Lesions
Yes TR-588 5694-00-8 Glycidamide Mice MV Male Dosed-Water Forestomach Clear Evidence Clear Evidence squamous cell papilloma 0/47 2/45 3/48 2/45 10/41 squamous cell carcinoma 0/47 0/45 0/48 0/45 2/41 squamous cell papilloma or carcinoma 0/47 2/45 3/48 2/45 12/41 Neoplastic Lesions
Yes TR-575 79-06-1 Acrylamide Mice MV Male Dosed-Water Forestomach Clear Evidence Clear Evidence squamous cell papilloma 0/46 2/45 2/46 6/47 6/44 squamous cell carcinoma 0/46 0/45 0/46 1/47 2/44 squamous cell papilloma or carcinoma 0/46 2/45 2/46 7/47 8/44 Neoplastic Lesions
Yes TR-579 99-97-8 N,N-Dimethyl-p-toluidine Mice B6C3F1/N Female Gavage Forestomach Clear Evidence Clear Evidence squamous cell papilloma 1/50, 5/50, 6/50, 7/50; squamous cell papilloma or carcinoma 1/50, 6/50, 6/50, 7/50 Neoplastic Lesions
Yes TR-544 3252-43-5 Water disinfection byproducts (Dibromoacetonitrile) Mice B6C3F1/N Female Dosed-Water Forestomach Clear Evidence Clear Evidence Squamous cell papilloma 1/50 0/50 5/50 14/50 Neoplastic Lesions
Yes TR-544 3252-43-5 Water disinfection byproducts (Dibromoacetonitrile) Mice B6C3F1/N Male Dosed-Water Forestomach Clear Evidence Clear Evidence Squamous cell papilloma or carcinoma 0/50 1/50 0/50 5/50 Neoplastic Lesions
Yes TR-558 14047-09-7 3,3',4,4'-Tetrachloroazobenzene Mice B6C3F1/N Male Gavage Forestomach Clear Evidence Clear Evidence Squamous cell carcinoma 0/50 1/50 1/49 3/50 Neoplastic Lesions
Yes TR-550 1319-77-3 Cresols Mice B6C3F1/N Female Dosed-Feed Forestomach Some Evidence Some Evidence squamous cell papilloma (0/50 1/50 1/49 10/50) Neoplastic Lesions
Yes TR-558 14047-09-7 3,3',4,4'-Tetrachloroazobenzene Mice B6C3F1/N Female Gavage Forestomach Clear Evidence Clear Evidence Squamous cell carcinoma 0/50 1/50 1/50 4/50 Neoplastic Lesions
Yes TR-588 5694-00-8 Glycidamide Rats F344 (NCTR) Female Dosed-Water Forestomach Clear Evidence Clear Evidence squamous cell papilloma 0/48 1/48 0/48 0/47 3/46 Neoplastic Lesions