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The DNTP Technical Report (TR) Level of Evidence Criteria are available here: https://ntp.niehs.nih.gov/go/baresults. In the table below this information is further delineated into three fields:

  • Level of Evidence: The overall category of evidence of carcinogenic activity for the TR, Species, Strain and Sex
  • Organ Site Call: The level of evidence supported by the specific organ site for the TR, Species, Strain and Sex. When the Organ Site Call directly supports the TR Level Of Evidence the Finding Type flag is set to “Neoplastic Lesion”. Some Organ Site Calls could support a separate call of Equivocal Evidence; this is noted in Finding Type by the flag “May Have Been Related”
  • Finding Type: Further identification of the Organ Site Call. Where this says “Neoplastic Lesion” the Organ Site Call supports the TR Level of Evidence and the Organ Site Call is the same as that of the TR. Where Finding Type says “May Have Been Related” the TR Level of Evidence for other responses led to an overall call of Clear or Some Evidence but the specified organ supports a call of Equivocal Evidence.
View results
  • Organ: Harderian Gland
  • Level of Evidence: Positive, Clear Evidence, Some Evidence
Displays results that match exactly with the given criteria.
Exact Match Publication No. CASRN Test Article Name Species Strain Sex Route Organ Level of Evidence Organ Site Call Tumor Type/Incidence Finding Type
Yes TR-100 135-20-6 Cupferron Mice B6C3F1 Female Dosed-Feed Harderian Gland Positive Positive ADENOMA Neoplastic Lesions
Yes TR-205 101-80-4 4,4'-Oxydianiline Mice B6C3F1 Female Dosed-Feed Harderian Gland Positive Positive (ADENOMA) Neoplastic Lesions
Yes TR-205 101-80-4 4,4'-Oxydianiline Mice B6C3F1 Male Dosed-Feed Harderian Gland Positive Positive (ADENOMA) Neoplastic Lesions
Yes TR-289 71-43-2 Benzene Mice B6C3F1 Male Gavage Harderian Gland Clear Evidence Clear Evidence ADENOMA 0/49 9/46 13/49 11/48 Neoplastic Lesions
Yes TR-434 106-99-0 1,3-Butadiene Mice B6C3F1 Male Inhalation Harderian Gland Clear Evidence Clear Evidence ADENOMA OR CARCINOMA 6/50 7/50 9/50 20/50 31/50 6/73, STOP STUDY 27/50 23/50 30/50 13/50 Neoplastic Lesions
Yes TR-384 96-18-4 1,2,3-Trichloropropane Mice B6C3F1 Female Gavage Harderian Gland Clear Evidence Clear Evidence ADENOMA 2/50 6/50 7/51 10/55 Neoplastic Lesions
Yes TR-374 556-52-5 Glycidol Mice B6C3F1 Male Gavage Harderian Gland Clear Evidence Clear Evidence ADENOMA 7/50 10/50 16/50 OR ADENOCARCINOMA 1/50 2/50 7/50 COMBINED 8/50 12/50 22/50 Neoplastic Lesions
Yes TR-352 924-42-5 N-Methylolacrylamide Mice B6C3F1 Female Gavage Harderian Gland Clear Evidence Clear Evidence ADENOMA 5/47 8/45 20/48 Neoplastic Lesions
Yes TR-352 924-42-5 N-Methylolacrylamide Mice B6C3F1 Male Gavage Harderian Gland Clear Evidence Clear Evidence ADENOMA 1/48 14/49 29/50 Neoplastic Lesions
Yes TR-434 106-99-0 1,3-Butadiene Mice B6C3F1 Female Inhalation Harderian Gland Clear Evidence Clear Evidence ADENOMA OR CARCINOMA 8/50 10/50 7/50 15/50 20/50 9/80 Neoplastic Lesions
Yes TR-384 96-18-4 1,2,3-Trichloropropane Mice B6C3F1 Male Gavage Harderian Gland Clear Evidence Clear Evidence ADENOMA 1/52 2/51 10/54 11/56 Neoplastic Lesions
Yes TR-326 75-21-8 Ethylene oxide Mice B6C3F1 Female Inhalation Harderian Gland Clear Evidence Clear Evidence CYSTADENOMA 1/46 6/46 8/47 Neoplastic Lesions
Yes TR-326 75-21-8 Ethylene oxide Mice B6C3F1 Male Inhalation Harderian Gland Clear Evidence Clear Evidence CYSTADENOMA 1/43 9/44 8/42 Neoplastic Lesions
Yes TR-340 5634-39-9 Iodinated glycerol Mice B6C3F1 Female Gavage Harderian Gland Some Evidence Some Evidence ADENOMA 6/50 8/40 13/50 OR CARCINOMA 0/50 0/40 1/50 COMBINED 6/50 8/40 14/50 Neoplastic Lesions
Yes TR-374 556-52-5 Glycidol Mice B6C3F1 Female Gavage Harderian Gland Clear Evidence Clear Evidence ADENOMA 4/50 10/50 16/50 OR ADENOCARCINOMA 0/50 1/50 1/50 COMBINED 4/50 11/50 17/50 Neoplastic Lesions
Yes TR-461 75-52-5 Nitromethane Mice B6C3F1 Male Inhalation Harderian Gland Clear Evidence Clear Evidence ADENOMA 9/50 10/50 19/50 32/50 OR CARCINOMA 1/50 1/50 6/50 5/50 COMBINED 10/50 11/50 25/50 37/50 Neoplastic Lesions
Yes TR-452 3296-90-0 2,2-bis(Bromomethyl)-1,3-propanediol Mice B6C3F1 Male Dosed-Feed Harderian Gland Clear Evidence Clear Evidence ADENOMA 3/50 6/51 12/50 18/49 OR CARCINOMA 1/50 1/51 4/50 4/49 COMBINED 4/50 7/51 16/50 22/49 Neoplastic Lesions
Yes TR-461 75-52-5 Nitromethane Mice B6C3F1 Female Inhalation Harderian Gland Clear Evidence Clear Evidence ADENOMA 5/50 7/50 16/50 19/50 OR CARCINOMA 1/50 2/50 4/50 3/50 COMBINED 6/50 9/50 20/50 21/50 Neoplastic Lesions
Yes TR-467 126-99-8 Chloroprene Mice B6C3F1 Male Inhalation Harderian Gland Clear Evidence Clear Evidence ADENOMA 2/50 5/50 8/50 10/50 OR CARCINOMA 0/50 0/50 2/50 2/50 COMBINED 2/50 5/50 10/50 12/50 Neoplastic Lesions
Yes TR-467 126-99-8 Chloroprene Mice B6C3F1 Female Inhalation Harderian Gland Clear Evidence Clear Evidence ADENOMA 1/50 3/50 3/50 8/50 OR CARCINOMA 1/50 2/50 0/50 1/50 COMBINED 2/50 5/50 3/50 9/50 Neoplastic Lesions
Yes TR-506 107-13-1 Acrylonitrile Mice B6C3F1 Female Gavage Harderian Gland Clear Evidence Clear Evidence ADENOMA 10/50 10/50 25/50 23/50 ADENOMA OR CARCINOMA 11/50 10/50 26/50 25/50 Neoplastic Lesions
Yes TR-510 51-79-6 Urethane Mice MV Female Dosed-Water Harderian Gland Clear Evidence Clear Evidence ADENOMA 3/48 10/48 8/48 21/48 CARCINOMA 0/48 1/48 11/48 11/48 COMBINED 3/48 11/48 19/48 30/48 Neoplastic Lesions
Yes TR-510 51-79-6 Urethane Mice MV Male Dosed-Water Harderian Gland Clear Evidence Clear Evidence ADENOMA 3/47 11/47 25/47 28/47 CARCINOMA 0/47 1/47 7/47 16/47 COMBINED 3/47 12/47 30/47 38/47 Neoplastic Lesions
Yes TR-506 107-13-1 Acrylonitrile Mice B6C3F1 Male Gavage Harderian Gland Clear Evidence Clear Evidence ADENOMA 5/50 16/50 24/50 27/50 ADENOMA OR CARCINOMA 6/50 16/50 27/50 30/50 Neoplastic Lesions
Yes TR-510 URETHCOMB Urethane + ethanol (combination) Mice MV Female Dosed-Water Harderian Gland Clear Evidence Clear Evidence (URETHANE AND 2.5% ETHANOL) ADENOMA 2/47 3/47 9/46 19/47 CARCINOMA 1/47 3/47 6/46 16/47 COMBINED 3/47 5/47 15/46 35/47 Neoplastic Lesions
Yes TR-510 URETHCOMB Urethane + ethanol (combination) Mice MV Female Dosed-Water Harderian Gland Clear Evidence Clear Evidence (URETHANE AND 5% ETHANOL) ADENOMA 4/48 7/48 6/46 20/46 CARCINOMA 1/48 11/48 7/46 10/46 COMBINED 5/48 18/48 13/46 29/46 Neoplastic Lesions
Yes TR-452 3296-90-0 2,2-bis(Bromomethyl)-1,3-propanediol Mice B6C3F1 Female Dosed-Feed Harderian Gland Clear Evidence Clear Evidence ADENOMA 2/52 6/50 8/51 15/50 OR CARCINOMA 1/52 6/50 5/51 7/50 COMBINED 3/52 12/50 13/51 19/50 Neoplastic Lesions
Yes TR-510 URETHCOMB Urethane + ethanol (combination) Mice MV Male Dosed-Water Harderian Gland Clear Evidence Clear Evidence (URETHANE AND 2.5% ETHANOL) ADENOMA 6/48 14/48 21/47 27/48 CARCINOMA 0/48 0/48 1/47 16/48 COMBINED 6/48 14/48 21/47 38/48 Neoplastic Lesions
Yes TR-510 URETHCOMB Urethane + ethanol (combination) Mice MV Male Dosed-Water Harderian Gland Clear Evidence Clear Evidence (URETHANE AND 5% ETHANOL) ADENOMA 5/47 12/48 15/48 26/45 CARCINOMA 0/47 2/48 2/48 10/45 COMBINED 5/47 14/48 17/48 35/45 Neoplastic Lesions
Yes TR-575 79-06-1 Acrylamide Mice MV Female Dosed-Water Harderian Gland Clear Evidence Clear Evidence adenoma 0/45 8/44 20/48 32/47 31/43 Neoplastic Lesions
Yes TR-588 5694-00-8 Glycidamide Mice MV Female Dosed-Water Harderian Gland Clear Evidence Clear Evidence adenoma 2/45 19/47 20/47 24/46 40/46 Neoplastic Lesions
Yes TR-588 5694-00-8 Glycidamide Mice MV Male Dosed-Water Harderian Gland Clear Evidence Clear Evidence adenoma 3/47 17/47 23/47 32/46 42/47 Neoplastic Lesions
Yes TR-575 79-06-1 Acrylamide Mice MV Male Dosed-Water Harderian Gland Clear Evidence Clear Evidence adenoma 2/46 13/46 27/47 36/47 39/47 adenocarcinoma 0/46 0/46 0/47 1/47 1/47 adenoma or adenocarcinoma 2/46 13/46 27/47 37/47 39/47 Neoplastic Lesions
Yes TR-583 71133-14-7 Water disinfection byproducts (Bromodichloroacetic Acid) Mice B6C3F1/N Male Dosed-Water Harderian Gland Clear Evidence Clear Evidence adenoma 6/50 11/50 14/49 19/51 adenoma or carcinoma 6/50 11/50 14/49 20/51 Neoplastic Lesions
Yes TR-594 98-56-6 p-Chloro-a,a,a-trifluorotoluene Mice B6C3F1 Female Inhalation Harderian Gland Clear Evidence Clear Evidence adenoma (2/50, 6/50, 6/50, 8/50); adenoma or adenocarcinoma (2/50, 6/50, 9/50, 8/50) Neoplastic Lesions
Yes TR-552 107-19-7 Propargyl alcohol Mice B6C3F1/N Male Inhalation Harderian Gland Some Evidence Equivocal Evidence adenoma 3/50, 10/50, 6/50, 11/50 May Have Been Related