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The DNTP Technical Report (TR) Level of Evidence Criteria are available here: https://ntp.niehs.nih.gov/go/baresults. In the table below this information is further delineated into three fields:

Level of Evidence: The overall category of evidence of carcinogenic activity for the TR, Species, Strain and Sex
Organ Site Call: The level of evidence supported by the specific organ site for the TR, Species, Strain and Sex. When the Organ Site Call directly supports the TR Level Of Evidence the Finding Type flag is set to “Neoplastic Lesion”. Some Organ Site Calls could support a separate call of Equivocal Evidence; this is noted in Finding Type by the flag “May Have Been Related”
Finding Type: Further identification of the Organ Site Call. Where this says “Neoplastic Lesion” the Organ Site Call supports the TR Level of Evidence and the Organ Site Call is the same as that of the TR. Where Finding Type says “May Have Been Related” the TR Level of Evidence for other responses led to an overall call of Clear or Some Evidence but the specified organ supports a call of Equivocal Evidence.

Displays results that match exactly with the given criteria.
Exact Match	Publication No.	CASRN	Test Article Name	Species	Strain	Sex	Route	Organ	Level of Evidence	Organ Site Call	Tumor Type/Incidence	Finding Type
Yes	TR-100	135-20-6	Cupferron	Mice	B6C3F1	Female	Dosed-Feed	Harderian Gland	Positive	Positive	ADENOMA	Neoplastic Lesions
Yes	TR-205	101-80-4	4,4'-Oxydianiline	Mice	B6C3F1	Female	Dosed-Feed	Harderian Gland	Positive	Positive	(ADENOMA)	Neoplastic Lesions
Yes	TR-205	101-80-4	4,4'-Oxydianiline	Mice	B6C3F1	Male	Dosed-Feed	Harderian Gland	Positive	Positive	(ADENOMA)	Neoplastic Lesions
Yes	TR-289	71-43-2	Benzene	Mice	B6C3F1	Male	Gavage	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 0/49 9/46 13/49 11/48	Neoplastic Lesions
Yes	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA OR CARCINOMA 6/50 7/50 9/50 20/50 31/50 6/73, STOP STUDY 27/50 23/50 30/50 13/50	Neoplastic Lesions
Yes	TR-384	96-18-4	1,2,3-Trichloropropane	Mice	B6C3F1	Female	Gavage	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 2/50 6/50 7/51 10/55	Neoplastic Lesions
Yes	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Male	Gavage	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 7/50 10/50 16/50 OR ADENOCARCINOMA 1/50 2/50 7/50 COMBINED 8/50 12/50 22/50	Neoplastic Lesions
Yes	TR-352	924-42-5	N-Methylolacrylamide	Mice	B6C3F1	Female	Gavage	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 5/47 8/45 20/48	Neoplastic Lesions
Yes	TR-352	924-42-5	N-Methylolacrylamide	Mice	B6C3F1	Male	Gavage	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 1/48 14/49 29/50	Neoplastic Lesions
Yes	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA OR CARCINOMA 8/50 10/50 7/50 15/50 20/50 9/80	Neoplastic Lesions
Yes	TR-384	96-18-4	1,2,3-Trichloropropane	Mice	B6C3F1	Male	Gavage	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 1/52 2/51 10/54 11/56	Neoplastic Lesions
Yes	TR-326	75-21-8	Ethylene oxide	Mice	B6C3F1	Female	Inhalation	Harderian Gland	Clear Evidence	Clear Evidence	CYSTADENOMA 1/46 6/46 8/47	Neoplastic Lesions
Yes	TR-326	75-21-8	Ethylene oxide	Mice	B6C3F1	Male	Inhalation	Harderian Gland	Clear Evidence	Clear Evidence	CYSTADENOMA 1/43 9/44 8/42	Neoplastic Lesions
Yes	TR-340	5634-39-9	Iodinated glycerol	Mice	B6C3F1	Female	Gavage	Harderian Gland	Some Evidence	Some Evidence	ADENOMA 6/50 8/40 13/50 OR CARCINOMA 0/50 0/40 1/50 COMBINED 6/50 8/40 14/50	Neoplastic Lesions
Yes	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Female	Gavage	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 4/50 10/50 16/50 OR ADENOCARCINOMA 0/50 1/50 1/50 COMBINED 4/50 11/50 17/50	Neoplastic Lesions
Yes	TR-461	75-52-5	Nitromethane	Mice	B6C3F1	Male	Inhalation	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 9/50 10/50 19/50 32/50 OR CARCINOMA 1/50 1/50 6/50 5/50 COMBINED 10/50 11/50 25/50 37/50	Neoplastic Lesions
Yes	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Male	Dosed-Feed	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 3/50 6/51 12/50 18/49 OR CARCINOMA 1/50 1/51 4/50 4/49 COMBINED 4/50 7/51 16/50 22/49	Neoplastic Lesions
Yes	TR-461	75-52-5	Nitromethane	Mice	B6C3F1	Female	Inhalation	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 5/50 7/50 16/50 19/50 OR CARCINOMA 1/50 2/50 4/50 3/50 COMBINED 6/50 9/50 20/50 21/50	Neoplastic Lesions
Yes	TR-467	126-99-8	Chloroprene	Mice	B6C3F1	Male	Inhalation	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 2/50 5/50 8/50 10/50 OR CARCINOMA 0/50 0/50 2/50 2/50 COMBINED 2/50 5/50 10/50 12/50	Neoplastic Lesions
Yes	TR-467	126-99-8	Chloroprene	Mice	B6C3F1	Female	Inhalation	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 1/50 3/50 3/50 8/50 OR CARCINOMA 1/50 2/50 0/50 1/50 COMBINED 2/50 5/50 3/50 9/50	Neoplastic Lesions
Yes	TR-506	107-13-1	Acrylonitrile	Mice	B6C3F1	Female	Gavage	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 10/50 10/50 25/50 23/50 ADENOMA OR CARCINOMA 11/50 10/50 26/50 25/50	Neoplastic Lesions
Yes	TR-510	51-79-6	Urethane	Mice	MV	Female	Dosed-Water	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 3/48 10/48 8/48 21/48 CARCINOMA 0/48 1/48 11/48 11/48 COMBINED 3/48 11/48 19/48 30/48	Neoplastic Lesions
Yes	TR-510	51-79-6	Urethane	Mice	MV	Male	Dosed-Water	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 3/47 11/47 25/47 28/47 CARCINOMA 0/47 1/47 7/47 16/47 COMBINED 3/47 12/47 30/47 38/47	Neoplastic Lesions
Yes	TR-506	107-13-1	Acrylonitrile	Mice	B6C3F1	Male	Gavage	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 5/50 16/50 24/50 27/50 ADENOMA OR CARCINOMA 6/50 16/50 27/50 30/50	Neoplastic Lesions
Yes	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Female	Dosed-Water	Harderian Gland	Clear Evidence	Clear Evidence	(URETHANE AND 2.5% ETHANOL) ADENOMA 2/47 3/47 9/46 19/47 CARCINOMA 1/47 3/47 6/46 16/47 COMBINED 3/47 5/47 15/46 35/47	Neoplastic Lesions
Yes	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Female	Dosed-Water	Harderian Gland	Clear Evidence	Clear Evidence	(URETHANE AND 5% ETHANOL) ADENOMA 4/48 7/48 6/46 20/46 CARCINOMA 1/48 11/48 7/46 10/46 COMBINED 5/48 18/48 13/46 29/46	Neoplastic Lesions
Yes	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Female	Dosed-Feed	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 2/52 6/50 8/51 15/50 OR CARCINOMA 1/52 6/50 5/51 7/50 COMBINED 3/52 12/50 13/51 19/50	Neoplastic Lesions
Yes	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Male	Dosed-Water	Harderian Gland	Clear Evidence	Clear Evidence	(URETHANE AND 2.5% ETHANOL) ADENOMA 6/48 14/48 21/47 27/48 CARCINOMA 0/48 0/48 1/47 16/48 COMBINED 6/48 14/48 21/47 38/48	Neoplastic Lesions
Yes	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Male	Dosed-Water	Harderian Gland	Clear Evidence	Clear Evidence	(URETHANE AND 5% ETHANOL) ADENOMA 5/47 12/48 15/48 26/45 CARCINOMA 0/47 2/48 2/48 10/45 COMBINED 5/47 14/48 17/48 35/45	Neoplastic Lesions
Yes	TR-575	79-06-1	Acrylamide	Mice	MV	Female	Dosed-Water	Harderian Gland	Clear Evidence	Clear Evidence	adenoma 0/45 8/44 20/48 32/47 31/43	Neoplastic Lesions
Yes	TR-588	5694-00-8	Glycidamide	Mice	MV	Female	Dosed-Water	Harderian Gland	Clear Evidence	Clear Evidence	adenoma 2/45 19/47 20/47 24/46 40/46	Neoplastic Lesions
Yes	TR-588	5694-00-8	Glycidamide	Mice	MV	Male	Dosed-Water	Harderian Gland	Clear Evidence	Clear Evidence	adenoma 3/47 17/47 23/47 32/46 42/47	Neoplastic Lesions
Yes	TR-575	79-06-1	Acrylamide	Mice	MV	Male	Dosed-Water	Harderian Gland	Clear Evidence	Clear Evidence	adenoma 2/46 13/46 27/47 36/47 39/47 adenocarcinoma 0/46 0/46 0/47 1/47 1/47 adenoma or adenocarcinoma 2/46 13/46 27/47 37/47 39/47	Neoplastic Lesions
Yes	TR-583	71133-14-7	Water disinfection byproducts (Bromodichloroacetic Acid)	Mice	B6C3F1/N	Male	Dosed-Water	Harderian Gland	Clear Evidence	Clear Evidence	adenoma 6/50 11/50 14/49 19/51 adenoma or carcinoma 6/50 11/50 14/49 20/51	Neoplastic Lesions
Yes	TR-594	98-56-6	p-Chloro-a,a,a-trifluorotoluene	Mice	B6C3F1	Female	Inhalation	Harderian Gland	Clear Evidence	Clear Evidence	adenoma (2/50, 6/50, 6/50, 8/50); adenoma or adenocarcinoma (2/50, 6/50, 9/50, 8/50)	Neoplastic Lesions
Yes	TR-552	107-19-7	Propargyl alcohol	Mice	B6C3F1/N	Male	Inhalation	Harderian Gland	Some Evidence	Equivocal Evidence	adenoma 3/50, 10/50, 6/50, 11/50	May Have Been Related

Displays all results in TRs which have data that match the given criteria.
Exact Match	Publication No.	CASRN	Test Article Name	Species	Strain	Sex	Route	Organ	Level of Evidence	Organ Site Call	Tumor Type/Incidence	Finding Type
No	TR-384	96-18-4	1,2,3-Trichloropropane	Rats	F344/N	Female	Gavage	Clitoral Gland	Clear Evidence	Clear Evidence	ADENOMA 5/46 10/46 13/50 10/51 OR CARCINOMA 0/46 0/46 4/50 6/51 COMBINED 5/46 10/46 17/50 15/51	Neoplastic Lesions
No	TR-384	96-18-4	1,2,3-Trichloropropane	Mice	B6C3F1	Female	Gavage	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 23/50 18/51 29/55; SQUAMOUS CELL CARCINOMA 0/50 46/50 49/51 49/55	Neoplastic Lesions
No	TR-384	96-18-4	1,2,3-Trichloropropane	Mice	B6C3F1	Male	Gavage	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 3/52 28/51 22/54 33/56; SQUAMOUS CELL CARCINOMA 0/52 40/51 50/54 51/56	Neoplastic Lesions
No	TR-384	96-18-4	1,2,3-Trichloropropane	Rats	F344/N	Female	Gavage	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 13/49 32/51 17/52; SQUAMOUS CELL CARCINOMA 0/50 3/49 9/51 4/52	Neoplastic Lesions
No	TR-384	96-18-4	1,2,3-Trichloropropane	Rats	F344/N	Male	Gavage	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 29/50 33/49 38/52; SQUAMOUS CELL CARCINOMA 0/50 9/50 27/49 13/52	Neoplastic Lesions
Yes	TR-384	96-18-4	1,2,3-Trichloropropane	Mice	B6C3F1	Female	Gavage	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 2/50 6/50 7/51 10/55	Neoplastic Lesions
Yes	TR-384	96-18-4	1,2,3-Trichloropropane	Mice	B6C3F1	Male	Gavage	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 1/52 2/51 10/54 11/56	Neoplastic Lesions
No	TR-384	96-18-4	1,2,3-Trichloropropane	Rats	F344/N	Female	Gavage	Intestines (Large)	Clear Evidence	Equivocal Evidence	ADENOCARCINOMA 0/49 0/47 1/52 2/52	May Have Been Related
No	TR-384	96-18-4	1,2,3-Trichloropropane	Rats	F344/N	Male	Gavage	Intestines (Large)	Clear Evidence	Equivocal Evidence	ADENOCARCINOMA 0/50 0/50 2/48 1/52	May Have Been Related
No	TR-384	96-18-4	1,2,3-Trichloropropane	Rats	F344/N	Male	Gavage	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 2/50 20/49 21/52	Neoplastic Lesions
No	TR-384	96-18-4	1,2,3-Trichloropropane	Mice	B6C3F1	Female	Gavage	Liver	Clear Evidence	Clear Evidence	ADENOMA 6/50 9/50 8/51 31/55 OR CARCINOMA 1/50 3/50 0/51 2/55 COMBINED 7/50 11/50 8/51 31/55	Neoplastic Lesions
No	TR-384	96-18-4	1,2,3-Trichloropropane	Mice	B6C3F1	Male	Gavage	Liver	Clear Evidence	Clear Evidence	ADENOMA 11/52 18/51 21/54 29/56; CARCINOMA 13/52 24/51 24/54 31/56	Neoplastic Lesions
No	TR-384	96-18-4	1,2,3-Trichloropropane	Rats	F344/N	Female	Gavage	Mammary Gland	Clear Evidence	Clear Evidence	ADENOCARCINOMA 1/50 6/49 12/52 21/52	Neoplastic Lesions
No	TR-384	96-18-4	1,2,3-Trichloropropane	Mice	B6C3F1	Male	Gavage	Oral Cavity	Clear Evidence	Equivocal Evidence	SQUAMOUS CELL PAPILLOMA 0/52 0/51 0/54 2/56	May Have Been Related
No	TR-384	96-18-4	1,2,3-Trichloropropane	Mice	B6C3F1	Female	Gavage	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL CARCINOMA 0/50 0/50 1/51 5/55	Neoplastic Lesions
No	TR-384	96-18-4	1,2,3-Trichloropropane	Rats	F344/N	Female	Gavage	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 1/50 5/49 10/52 18/52 ; SQUAMOUS CELL CARCINOMA 0/50 1/49 21/52 21/52	Neoplastic Lesions
No	TR-384	96-18-4	1,2,3-Trichloropropane	Rats	F344/N	Male	Gavage	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 4/50 9/49 19/52; SQUAMOUS CELL CARCINOMA 1/50 0/50 11/49 25/52	Neoplastic Lesions
No	TR-384	96-18-4	1,2,3-Trichloropropane	Rats	F344/N	Male	Gavage	Pancreas Acinar Cell	Clear Evidence	Clear Evidence	ADENOMA 5/50 21/50 36/49 29/52	Neoplastic Lesions
No	TR-384	96-18-4	1,2,3-Trichloropropane	Rats	F344/N	Male	Gavage	Preputial Gland	Clear Evidence	Clear Evidence	ADENOMA 5/49 3/47 5/49 11/50 OR CARCINOMA 0/49 3/47 3/49 5/50 COMBINED 5/49 6/47 8/49 16/50	Neoplastic Lesions
No	TR-384	96-18-4	1,2,3-Trichloropropane	Mice	B6C3F1	Female	Gavage	Uterus/Cervix	Clear Evidence	Clear Evidence	ADENOMA 0/50 1/50 0/51 3/54; ADENOCARCINOMA 0/50 4/50 3/51 6/54; POLYP 0/50 2/50 1/51 6/54	Neoplastic Lesions
No	TR-384	96-18-4	1,2,3-Trichloropropane	Rats	F344/N	Female	Gavage	Zymbal Gland	Clear Evidence	Clear Evidence	CARCINOMA 0/60 1/59 0/60 4/60	Neoplastic Lesions
No	TR-384	96-18-4	1,2,3-Trichloropropane	Rats	F344/N	Male	Gavage	Zymbal Gland	Clear Evidence	Clear Evidence	CARCINOMA 0/60 0/60 0/59 3/60	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Brain	Clear Evidence	Clear Evidence	(STOP STUDY) GLIOMA 0/50 2/50 0/50 1/50	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA OR CARCINOMA 0/50 0/50 3/50 2/50 4/50 22/80	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA OR CARCINOMA 1/50 0/50 0/50 1/50 8/50 4/73, STOP STUDY 3/50 7/50 9/50 10/50	Neoplastic Lesions
Yes	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA OR CARCINOMA 8/50 10/50 7/50 15/50 20/50 9/80	Neoplastic Lesions
Yes	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA OR CARCINOMA 6/50 7/50 9/50 20/50 31/50 6/73, STOP STUDY 27/50 23/50 30/50 13/50	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Hematopoietic System	Clear Evidence	Clear Evidence	LYMPHOMA 6/50 12/50 11/50 7/50 9/50 32/80; HISTIOCYTIC SARCOMA 3/50 2/50 7/50 4/50 7/50 4/80	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Hematopoietic System	Clear Evidence	Clear Evidence	LYMPHOMA 4/50 2/50 4/50 6/50 2/50 51/73, STOP STUDY 8/50 22/50 8/50 33/50; HISTIOCYTIC SARCOMA 0/50 0/50 4/50 5/50 7/50 4/73, STOP STUDY 5/50 2/50 7/50 2/50	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Intestines (Small)	Clear Evidence	Equivocal Evidence	CARCINOMA 0/50 1/50 1/50 1/50 2/50 0/73	May Have Been Related
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Kidney Tubular Cell	Clear Evidence	Equivocal Evidence	ADENOMA 0/49 0/49 0/48 0/50 2/50 0/80	May Have Been Related
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 1/50 0/50 3/48 1/49 0/73, STOP STUDY 4/48 1/50 3/49 1/50	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Liver	Clear Evidence	Clear Evidence	ADENOMA OR CARCINOMA 15/49 14/49 15/50 19/50 16/50 2/80	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Liver	Clear Evidence	Clear Evidence	ADENOMA OR CARCINOMA 21/50 23/50 30/50 25/48 33/48 5/72, STOP STUDY 27/49 19/49 19/50 11/50	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA, ADENOCARCINOMA, OR CARCINOMA 4/50 15/50 19/50 24/50 25/50 22/78	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA, ADENOCARCINOMA, OR CARCINOMA 21/50 23/50 19/50 31/49 35/50 3/73, STOP STUDY 36/50 28/50 32/50 17/50	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Mammary Gland	Clear Evidence	Clear Evidence	ADENOACANTHOMA, ADENOCARCINOMA, OR MALIGNANT MIXED TUMOR 0/50 2/50 4/50 12/50 15/50 16/80	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Ovary	Clear Evidence	Clear Evidence	BENIGN OR MALIGNANT GRANULOSA CELL TUMOR 1/49 0/49 1/48 9/50 8/50 6/79; ADENOMA OR BENIGN MIXED TUMOR 2/49 4/49 1/48 4/50 6/50 2/79	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Preputial Gland	Clear Evidence	Clear Evidence	CARCINOMA 0/50 0/50 0/50 0/50 5/50 0/73, STOP STUDY 1/50 4/50 4/50 3/50	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Subcutaneous Tissue	Clear Evidence	Equivocal Evidence	NEUROFIBROSARCOMA OR SARCOMA 1/50 2/50 3/50 5/50 3/50 3/80	May Have Been Related
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Vascular System (Heart)	Clear Evidence	Clear Evidence	HEMANGIOSARCOMA 0/50 0/50 0/50 1/49 21/50 23/80	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Vascular System (Heart)	Clear Evidence	Clear Evidence	HEMANGIOSARCOMA 0/50 0/49 1/50 5/48 20/48 4/73, STOP STUDY 15/50 7/50 33/50 13/50	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Zymbal Gland	Clear Evidence	Equivocal Evidence	ADENOMA OR CARCINOMA 0/50 0/50 0/50 0/50 0/50 2/80	May Have Been Related
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Zymbal Gland	Clear Evidence	Equivocal Evidence	(STOP STUDY) CARCINOMA 1/50 0/50 2/50 2/50	May Have Been Related
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Female	Dosed-Feed	Esophagus	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 0/51 1/53 10/52	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Esophagus	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/51 0/53 1/51 5/55 0/60	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Female	Dosed-Feed	Forestomach	Clear Evidence	Equivocal Evidence	SQUAMOUS CELL PAPILLOMA 0/52 1/50 5/51 3/50	May Have Been Related
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Male	Dosed-Feed	Forestomach	Clear Evidence	Equivocal Evidence	SQUAMOUS CELL PAPILLOMA 0/50 3/51 2/50 2/49 OR SQUAMOUS CELL CARCINOMA 0/50 0/51 1/50 2/49 COMBINED 0/50 3/51 3/50 4/49	May Have Been Related
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/51 0/53 0/51 1/55 5/60	Neoplastic Lesions
Yes	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Female	Dosed-Feed	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 2/52 6/50 8/51 15/50 OR CARCINOMA 1/52 6/50 5/51 7/50 COMBINED 3/52 12/50 13/51 19/50	Neoplastic Lesions
Yes	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Male	Dosed-Feed	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 3/50 6/51 12/50 18/49 OR CARCINOMA 1/50 1/51 4/50 4/49 COMBINED 4/50 7/51 16/50 22/49	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Hematopoietic System	Clear Evidence	Clear Evidence	MONONUCLEAR CELL LEUKEMIA 27/51 29/53 40/51 34/55 25/60	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Intestines (Large)	Clear Evidence	Clear Evidence	ADENOMA OR CARCINOMA 0/51 0/53 3/51 4/55 11/59	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Intestines (Small)	Clear Evidence	Clear Evidence	ADENOMA OR CARCINOMA 0/51 0/53 0/51 2/53 5/59	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Kidney Tubular Cell	Clear Evidence	Equivocal Evidence	ADENOMA 0/51 0/53 1/51 3/55 1/59	May Have Been Related
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Male	Dosed-Feed	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 0/51 3/50 2/49	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Female	Dosed-Feed	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 3/52 3/50 9/51 17/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 2/52 2/50 6/51 5/50 COMBINED 5/52 5/50 15/51 19/50	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Male	Dosed-Feed	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 12/50 4/51 12/50 21/49 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 3/50 7/51 8/50 11/49 COMBINED 15/50 11/51 16/50 25/49	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 1/51 0/53 3/51 1/55 4/60 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/51 1/53 0/51 3/55 3/60 COMBINED 1/51 1/53 3/51 4/55 7/60	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Female	Dosed-Feed	Mammary Gland	Clear Evidence	Equivocal Evidence	CARCINOMA 0/52 0/50 1/51 2/50	May Have Been Related
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Female	Dosed-Feed	Mammary Gland	Clear Evidence	Clear Evidence	FIBROADENOMA 25/50 45/51 46/53 45/52	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Mammary Gland	Clear Evidence	Clear Evidence	FIBROADENOMA 0/51 4/53 6/51 6/55 5/60 OR ADENOMA 0/51 0/53 1/51 1/55 0/60 COMBINED 0/51 4/53 7/51 7/55 5/60	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Mesothelium (Abdominal Cavity/Tunica Vaginalis)	Clear Evidence	Clear Evidence	MESOTHELIOMA 0/51 3/53 8/51 9/55 26/60	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Female	Dosed-Feed	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 2/50 2/51 4/53 5/52 OR SQUAMOUS CELL CARCINOMA 0/50 1/51 1/53 1/52 COMBINED 2/50 3/51 5/53 6/52	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/51 4/53 8/51 10/55 12/60 OR SQUAMOUS CELL CARCINOMA 0/51 0/53 1/51 0/55 2/60 COMBINED 0/51 4/53 9/51 10/55 13/60	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Pancreas Acinar Cell	Clear Evidence	Equivocal Evidence	ADENOMA 1/51 2/53 4/51 3/53 3/59	May Have Been Related
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Seminal Vesicle	Clear Evidence	Clear Evidence	ADENOMA 0/51 0/53 0/51 0/55 1/59 OR CARCINOMA 0/51 0/53 0/51 0/55 1/59 COMBINED 0/51 0/53 0/51 0/55 2/59	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Skin	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 1/51 0/53 2/51 5/55 11/60 OR KERATOACANTHOMA 3/51 5/53 11/51 16/55 10/60 OR TRICHOEPITHELIOMA 0/51 0/53 0/51 1/55 1/60 OR BASAL CELL ADENOMA 0/51 1/53 0/51 3/55 6/60 OR BASAL CELL CARCINOMA 0/51 0/53 2/51 2/55 0/60 OR SQUAMOUS CELL CARCINOMA 0/51 0/53 0/51 0/55 1/60 COMBINED 4/51 6/53 14/51 24/55 21/60	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Female	Dosed-Feed	Subcutaneous Tissue	Clear Evidence	Clear Evidence	SARCOMA 0/52 1/50 4/51 11/50	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Subcutaneous Tissue	Clear Evidence	Clear Evidence	FIBROMA 2/51 8/53 11/51 15/55 7/60 OR FIBROSARCOMA 0/51 1/53 0/51 0/55 1/60 OR SARCOMA 0/51 0/53 2/51 3/55 2/60 COMBINED 2/51 9/53 13/51 16/55 10/60	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Female	Dosed-Feed	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 0/51 2/53 3/52 OR CARCINOMA 0/50 0/51 0/53 1/52 COMBINED 0/50 0/51 2/53 4/52	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/51 1/53 2/51 2/55 7/59 OR CARCINOMA 0/51 1/53 4/51 1/55 2/59 COMBINED 0/51 2/53 6/51 3/55 9/59	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Urinary Bladder	Clear Evidence	Clear Evidence	TRANSITIONAL CELL PAPILLOMA 0/51 0/53 1/51 2/55 1/59 OR TRANSITIONAL CELL CARCINOMA 0/51 0/53 0/51 1/55 1/59 COMBINED 0/51 0/53 1/51 3/55 2/59	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Female	Dosed-Feed	Vascular System (Unspecified)	Clear Evidence	Equivocal Evidence	HEMANGIOMA AND HEMANGIOSARCOMA 1/52 2/50 0/51 5/50	May Have Been Related
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Zymbal Gland	Clear Evidence	Clear Evidence	ADENOMA 0/51 0/53 1/51 3/55 2/60 OR CARCINOMA 2/51 1/53 3/51 2/55 15/60 COMBINED 2/51 1/53 4/51 5/55 15/60	Neoplastic Lesions
Yes	TR-205	101-80-4	4,4'-Oxydianiline	Mice	B6C3F1	Female	Dosed-Feed	Harderian Gland	Positive	Positive	(ADENOMA)	Neoplastic Lesions
Yes	TR-205	101-80-4	4,4'-Oxydianiline	Mice	B6C3F1	Male	Dosed-Feed	Harderian Gland	Positive	Positive	(ADENOMA)	Neoplastic Lesions
No	TR-205	101-80-4	4,4'-Oxydianiline	Mice	B6C3F1	Female	Dosed-Feed	Liver	Positive	Positive	(CARCINOMA)	Neoplastic Lesions
No	TR-205	101-80-4	4,4'-Oxydianiline	Mice	B6C3F1	Male	Dosed-Feed	Liver	Positive	Positive	(ADENOMA OR CARCINOMA)	Neoplastic Lesions
No	TR-205	101-80-4	4,4'-Oxydianiline	Rats	F344/N	Female	Dosed-Feed	Liver	Positive	Positive	(NEOPLASTIC NODULE, CARCINOMA)	Neoplastic Lesions
No	TR-205	101-80-4	4,4'-Oxydianiline	Rats	F344/N	Male	Dosed-Feed	Liver	Positive	Positive	(NEOPLASTIC NODULE, CARCINOMA)	Neoplastic Lesions
No	TR-205	101-80-4	4,4'-Oxydianiline	Mice	B6C3F1	Female	Dosed-Feed	Thyroid Gland Follicular Cell	Positive	Positive	ADENOMA	Neoplastic Lesions
No	TR-205	101-80-4	4,4'-Oxydianiline	Rats	F344/N	Female	Dosed-Feed	Thyroid Gland Follicular Cell	Positive	Positive	ADENOMA OR CARCINOMA	Neoplastic Lesions
No	TR-205	101-80-4	4,4'-Oxydianiline	Rats	F344/N	Male	Dosed-Feed	Thyroid Gland Follicular Cell	Positive	Positive	ADENOMA OR CARCINOMA	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Female	Dosed-Water	Clitoral Gland	Clear Evidence	Clear Evidence	carcinoma 1/4 6/48 12/47 3/48 8/47	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Male	Dosed-Water	Epididymis	Clear Evidence	Clear Evidence	malignant mesothelioma 2/48 2/48 1/48 5/48 8/48	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Male	Dosed-Water	Epididymis or Testis	Clear Evidence	Clear Evidence	malignant mesothelioma 2/48 2/48 1/48 5/48 8/48	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Mice	MV	Female	Dosed-Water	Forestomach	Clear Evidence	Clear Evidence	squamous cell papilloma 4/46 0/46 2/48 5/45 8/42	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Mice	MV	Male	Dosed-Water	Forestomach	Clear Evidence	Clear Evidence	squamous cell papilloma 0/46 2/45 2/46 6/47 6/44 squamous cell carcinoma 0/46 0/45 0/46 1/47 2/44 squamous cell papilloma or carcinoma 0/46 2/45 2/46 7/47 8/44	Neoplastic Lesions
Yes	TR-575	79-06-1	Acrylamide	Mice	MV	Female	Dosed-Water	Harderian Gland	Clear Evidence	Clear Evidence	adenoma 0/45 8/44 20/48 32/47 31/43	Neoplastic Lesions
Yes	TR-575	79-06-1	Acrylamide	Mice	MV	Male	Dosed-Water	Harderian Gland	Clear Evidence	Clear Evidence	adenoma 2/46 13/46 27/47 36/47 39/47 adenocarcinoma 0/46 0/46 0/47 1/47 1/47 adenoma or adenocarcinoma 2/46 13/46 27/47 37/47 39/47	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Female	Dosed-Water	Heart	Clear Evidence	Clear Evidence	malignant Schwannoma 2/48 1/48 0/48 2/48 4/48	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Male	Dosed-Water	Heart	Clear Evidence	Clear Evidence	malignant Schwannoma 1/48 2/48 3/48 4/48 6/48	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Female	Dosed-Water	Liver	Clear Evidence	Clear Evidence	adenoma 0/48 0/48 1/48 1/48 3/48	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Mice	MV	Female	Dosed-Water	Lung	Clear Evidence	Clear Evidence	alveolar/bronchiolar adenoma 1/47 4/47 6/48 11/45 19/45	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Mice	MV	Male	Dosed-Water	Lung	Clear Evidence	Clear Evidence	alveolar/bronchiolar adenoma 5/47 6/46 13/47 10/45 19/48 alveolar/bronchiolar adenoma or carcinoma 6/47 6/46 14/47 10/45 20/48	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Mice	MV	Female	Dosed-Water	Mammary Gland	Clear Evidence	Clear Evidence	adenoacanthoma 0/47 1/46 1/48 2/45 4/42 adenocarcinoma 0/47 4/46 6/48 2/45 13/42 adenoacanthoma or adenocarcinoma 0/47 4/46 7/48 4/45 17/42	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Female	Dosed-Water	Mammary Gland	Clear Evidence	Clear Evidence	fibroadenoma 16/48 18/48 24/46 22/47 31/48	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Female	Dosed-Water	Oral Cavity	Clear Evidence	Clear Evidence	squamous cell papilloma or carcinoma 0/48 2/48 1/48 3/48 5/48	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Mice	MV	Female	Dosed-Water	Ovary	Clear Evidence	Clear Evidence	benign granulose cell tumor 0/46 1/45 0/48 1/45 5/42	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Male	Dosed-Water	Pancreas Islet Cell	Clear Evidence	Clear Evidence	adenoma 1/46 2/48 4/48 1/48 6/48 carcinoma 0/46 0/48 0/48 1/48 0/48 adenoma or carcinoma 1/46 2/48 4/48 2/48 6/48	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Mice	MV	Female	Dosed-Water	Skin	Clear Evidence	Clear Evidence	fibrosarcoma, fibrous histocytoma, myxosarcoma, neurofibrosarcoma, or sarcoma 0/48 0/46 3/48 10/45 6/43 squamous cell carcinoma 0/48 0/46 0/48 0/45 2/43	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Female	Dosed-Water	Skin	Clear Evidence	Clear Evidence	subcutaneous tissue fibroma, fibrosarcoma or sarcoma 1/48 0/48 0/48 1/48 5/48	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Male	Dosed-Water	Testis	Clear Evidence	Clear Evidence	malignant mesothelioma 1/48 2/48 1/48 1/48 5/48	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Female	Dosed-Water	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	adenoma 0/48 0/48 1/48 0/48 2/47 carcinoma 0/48 0/48 1/48 3/48 2/47 adenoma or carcinoma 0/48 0/48 2/48 3/48 4/47	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Male	Dosed-Water	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	adenoma 0/47 1/48 1/47 1/48 3/48 carcinoma 1/47 2/48 3/47 6/48 6/48 l adenoma or carcinoma 1/47 3/48 4/47 6/48 9/48	Neoplastic Lesions
No	TR-506	107-13-1	Acrylonitrile	Mice	B6C3F1	Female	Gavage	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 3/50 6/50 24/50 19/50 SQUAMOUS CELL CARCINOMA 0/50 1/50 1/50 11/50 COMBINED 3/50 7/50 25/50 29/50	Neoplastic Lesions
No	TR-506	107-13-1	Acrylonitrile	Mice	B6C3F1	Male	Gavage	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 3/50 4/50 19/50 25/50; SQUAMOUS CELL CARCINOMA 0/50 0/50 8/50 9/50 COMBINED 3/50 4/50 26/50 32/50	Neoplastic Lesions
Yes	TR-506	107-13-1	Acrylonitrile	Mice	B6C3F1	Female	Gavage	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 10/50 10/50 25/50 23/50 ADENOMA OR CARCINOMA 11/50 10/50 26/50 25/50	Neoplastic Lesions
Yes	TR-506	107-13-1	Acrylonitrile	Mice	B6C3F1	Male	Gavage	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 5/50 16/50 24/50 27/50 ADENOMA OR CARCINOMA 6/50 16/50 27/50 30/50	Neoplastic Lesions
No	TR-506	107-13-1	Acrylonitrile	Mice	B6C3F1	Female	Gavage	Lung	Clear Evidence	Equivocal Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA OR CARCINOMA 6/50 6/50 14/50 9/50	May Have Been Related
No	TR-506	107-13-1	Acrylonitrile	Mice	B6C3F1	Female	Gavage	Ovary	Clear Evidence	Equivocal Evidence	BENIGN OR MALIGNANT GRANULOSA CELL TUMOR 0/50 0/50 4/50 1/50	May Have Been Related
Yes	TR-289	71-43-2	Benzene	Mice	B6C3F1	Male	Gavage	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 0/49 9/46 13/49 11/48	Neoplastic Lesions
No	TR-289	71-43-2	Benzene	Mice	B6C3F1	Female	Gavage	Hematopoietic System	Clear Evidence	Clear Evidence	LYMPHOMA 15/49 25/45 26/50 22/49	Neoplastic Lesions
No	TR-289	71-43-2	Benzene	Mice	B6C3F1	Male	Gavage	Hematopoietic System	Clear Evidence	Clear Evidence	LYMPHOMA 4/49 10/48 10/50 15/49	Neoplastic Lesions
No	TR-289	71-43-2	Benzene	Mice	B6C3F1	Female	Gavage	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 4/49 2/42 5/50 9/49 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/49 3/42 6/50 6/49 COMBINED 4/49 5/42 10/50 13/49	Neoplastic Lesions
No	TR-289	71-43-2	Benzene	Mice	B6C3F1	Male	Gavage	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 6/49 6/48 8/50 12/49 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 5/49 11/48 12/50 14/49 COMBINED 10/49 16/48 19/50 21/49	Neoplastic Lesions
No	TR-289	71-43-2	Benzene	Mice	B6C3F1	Female	Gavage	Mammary Gland	Clear Evidence	Clear Evidence	CARCINOMA 0/49 2/45 5/50 10/49; CARCINOSARCOMA 0/49 0/45 1/50 4/49	Neoplastic Lesions
No	TR-289	71-43-2	Benzene	Rats	F344/N	Female	Gavage	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 1/50 4/50 8/50 5/50 OR SQUAMOUS CELL CARCINOMA 0/50 1/50 4/50 5/50 COMBINED 1/50 5/50 12/50 9/50	Neoplastic Lesions
No	TR-289	71-43-2	Benzene	Rats	F344/N	Male	Gavage	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 1/50 6/50 11/50 13/50 OR SQUAMOUS CELL CARCINOMA 0/50 3/50 5/50 7/50 COMBINED 1/50 9/50 16/50 19/50	Neoplastic Lesions
No	TR-289	71-43-2	Benzene	Mice	B6C3F1	Female	Gavage	Ovary	Clear Evidence	Clear Evidence	BENIGN MIXED TUMORS 0/47 1/44 12/49 7/48; GRANULOSA CELL TUMOR 1/47 1/44 6/49 7/48	Neoplastic Lesions
No	TR-289	71-43-2	Benzene	Mice	B6C3F1	Male	Gavage	Preputial Gland	Clear Evidence	Clear Evidence	SQUAMOUS CELL CARCINOMA 0/21 3/28 18/29 28/35	Neoplastic Lesions
No	TR-289	71-43-2	Benzene	Rats	F344/N	Male	Gavage	Skin	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 2/50 1/50 5/50; SQUAMOUS CELL CARCINOMA 0/50 5/50 3/50 8/50	Neoplastic Lesions
No	TR-289	71-43-2	Benzene	Mice	B6C3F1	Female	Gavage	Zymbal Gland	Clear Evidence	Clear Evidence	SQUAMOUS CELL CARCINOMA 0/43 0/32 1/37 3/31	Neoplastic Lesions
No	TR-289	71-43-2	Benzene	Mice	B6C3F1	Male	Gavage	Zymbal Gland	Clear Evidence	Clear Evidence	SQUAMOUS CELL CARCINOMA 0/43 1/34 4/40 21/39	Neoplastic Lesions
No	TR-289	71-43-2	Benzene	Rats	F344/N	Female	Gavage	Zymbal Gland	Clear Evidence	Clear Evidence	CARCINOMA 0/45 5/40 5/44 14/46	Neoplastic Lesions
No	TR-289	71-43-2	Benzene	Rats	F344/N	Male	Gavage	Zymbal Gland	Clear Evidence	Clear Evidence	CARCINOMA 2/32 6/46 10/42	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Mice	B6C3F1	Female	Inhalation	Forestomach	Clear Evidence	Clear Evidence	Squamous Cell Papilloma 0/50 0/50 0/50 4/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Mice	B6C3F1	Male	Inhalation	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 1/50 0/50 2/50 4/50	Neoplastic Lesions
Yes	TR-467	126-99-8	Chloroprene	Mice	B6C3F1	Female	Inhalation	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 1/50 3/50 3/50 8/50 OR CARCINOMA 1/50 2/50 0/50 1/50 COMBINED 2/50 5/50 3/50 9/50	Neoplastic Lesions
Yes	TR-467	126-99-8	Chloroprene	Mice	B6C3F1	Male	Inhalation	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 2/50 5/50 8/50 10/50 OR CARCINOMA 0/50 0/50 2/50 2/50 COMBINED 2/50 5/50 10/50 12/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Mice	B6C3F1	Male	Inhalation	Kidney Tubular Cell	Clear Evidence	Clear Evidence	(SINGLE SECTIONS) ADENOMA 0/50 1/49 1/50 3/50 (SINGLE AND STEP SECTIONS) ADENOMA 0/50 2/49 3/50 9/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Rats	F344/N	Female	Inhalation	Kidney Tubular Cell	Clear Evidence	Clear Evidence	(SINGLE SECTIONS) ADENOMA 0/49 0/50 0/50 2/50 (SINGLE AND STEP SECTIONS) ADENOMA 0/49 0/50 0/50 4/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Rats	F344/N	Male	Inhalation	Kidney Tubular Cell	Clear Evidence	Clear Evidence	(SINGLE SECTIONS) ADENOMA 0/50 1/50 1/50 2/50 (SINGLE AND STEP SECTIONS) ADENOMA 1/50 7/50 6/50 7/50 OR CARCINOMA 0/50 2/50 0/50 1/50 COMBINED 1/50 9/50 6/50 8/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Mice	B6C3F1	Female	Inhalation	Liver	Clear Evidence	Clear Evidence	ADENOMA 17/50 19/49 11/50 16/50 OR CARCINOMA 4/50 11/49 14/50 19/50 COMBINED 20/50 26/49 20/50 30/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Rats	F344/N	Female	Inhalation	Lung	Clear Evidence	Equivocal Evidence	Alveolar/Bronchiolar Adenoma 1/49 0/50 0/50 3/50	May Have Been Related
No	TR-467	126-99-8	Chloroprene	Mice	B6C3F1	Female	Inhalation	Lung	Clear Evidence	Clear Evidence	Alveolar/Bronchiolar Adenoma 2/50 16/49 29/50 26/50 or Alveolar/Bronchiolar Carcinoma 2/50 14/49 16/50 28/50 Combined 4/50 28/49 34/50 42/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Mice	B6C3F1	Male	Inhalation	Lung	Clear Evidence	Clear Evidence	Alveolar/Bronchiolar Adenoma 8/50 18/50 22/50 28/50 or Alveolar/Bronchiolar Carcinoma 6/50 12/50 23/50 28/50 Combined 13/50 28/50 36/50 43/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Rats	F344/N	Male	Inhalation	Lung	Clear Evidence	Clear Evidence	Alveolar/Bronchiolar Adenoma 2/50 0/50 3/49 3/50 or Alveolar/Bronchiolar Carcinoma 0/50 2/50 1/49 4/50 Combined 2/50 2/50 4/49 6/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Mice	B6C3F1	Female	Inhalation	Mammary Gland	Clear Evidence	Clear Evidence	CARCINOMA 3/50 4/50 7/50 12/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Rats	F344/N	Female	Inhalation	Mammary Gland	Clear Evidence	Clear Evidence	FIBROADENOMA 24/49 32/50 36/50 36/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Mice	B6C3F1	Female	Inhalation	Mesothelium (Abdominal Cavity/Tunica Vaginalis)	Clear Evidence	Clear Evidence	SARCOMA 0/50 4/50 8/50 3/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Rats	F344/N	Female	Inhalation	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 1/49 2/50 2/50 7/50 OR SQUAMOUS CELL CARCINOMA 0/49 1/50 3/50 4/50 COMBINED 1/49 3/50 5/50 11/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Rats	F344/N	Male	Inhalation	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 2/50 4/50 10/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 1/50 2/50 COMBINED 0/50 2/50 5/50 12/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Mice	B6C3F1	Female	Inhalation	Subcutaneous Tissue	Clear Evidence	Clear Evidence	SARCOMA 0/50 11/50 11/50 18/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Rats	F344/N	Female	Inhalation	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 1/49 1/50 0/50 3/50 OR CARCINOMA 0/49 0/50 1/50 2/50 COMBINED 1/49 1/50 1/50 5/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Rats	F344/N	Male	Inhalation	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 2/50 2/49 4/50 OR CARCINOMA 0/50 0/50 2/49 1/50 COMBINED 0/50 2/50 4/49 5/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Rats	F344/N	Female	Inhalation	Urinary Bladder	Clear Evidence	Equivocal Evidence	TRANSITIONAL EPITHELIUM CARCINOMA 0/49 0/50 0/50 2/50	May Have Been Related
No	TR-467	126-99-8	Chloroprene	Rats	F344/N	Male	Inhalation	Urinary Bladder	Clear Evidence	Equivocal Evidence	TRANSITIONAL EPITHELIUM PAPILLOMA 0/50 0/50 0/50 1/49 OR CARCINOMA 0/50 0/50 1/50 0/49	May Have Been Related
No	TR-467	126-99-8	Chloroprene	Mice	B6C3F1	Female	Inhalation	Vascular System (Unspecified)	Clear Evidence	Clear Evidence	HEMANGIOMA 0/50 0/50 2/50 3/50 OR HEMANGIOSARCOMA 4/50 6/50 17/50 5/50 COMBINED 4/50 6/50 18/50 8/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Mice	B6C3F1	Male	Inhalation	Vascular System (Unspecified)	Clear Evidence	Clear Evidence	HEMANGIOMA 0/50 1/50 2/50 2/50 OR HEMANGIOSARCOMA 3/50 13/50 22/50 19/50 COMBINED 3/50 14/50 23/50 21/50	Neoplastic Lesions
No	TR-467	126-99-8	Chloroprene	Mice	B6C3F1	Female	Inhalation	Zymbal Gland	Clear Evidence	Clear Evidence	CARCINOMA 0/50 0/50 0/50 3/50	Neoplastic Lesions
No	TR-100	135-20-6	Cupferron	Rats	F344/N	Female	Dosed-Feed	Forestomach	Positive	Positive	SQUAMOUS CELL CARCINOMA	Neoplastic Lesions
No	TR-100	135-20-6	Cupferron	Rats	F344/N	Male	Dosed-Feed	Forestomach	Positive	Positive	SQUAMOUS CELL CARCINOMA	Neoplastic Lesions
Yes	TR-100	135-20-6	Cupferron	Mice	B6C3F1	Female	Dosed-Feed	Harderian Gland	Positive	Positive	ADENOMA	Neoplastic Lesions
No	TR-100	135-20-6	Cupferron	Mice	B6C3F1	Female	Dosed-Feed	Liver	Positive	Positive	CARCINOMA	Neoplastic Lesions
No	TR-100	135-20-6	Cupferron	Rats	F344/N	Female	Dosed-Feed	Liver	Positive	Positive	CARCINOMA	Neoplastic Lesions
No	TR-100	135-20-6	Cupferron	Rats	F344/N	Male	Dosed-Feed	Liver	Positive	Positive	CARCINOMA	Neoplastic Lesions
No	TR-100	135-20-6	Cupferron	Mice	B6C3F1	Female	Dosed-Feed	Vascular System (Unspecified)	Positive	Positive	HEMANGIOMA OR HEMANGIOSARCOMA	Neoplastic Lesions
No	TR-100	135-20-6	Cupferron	Mice	B6C3F1	Male	Dosed-Feed	Vascular System (Unspecified)	Positive	Positive	HEMANGIOSARCOMA	Neoplastic Lesions
No	TR-100	135-20-6	Cupferron	Rats	F344/N	Female	Dosed-Feed	Vascular System (Unspecified)	Positive	Positive	HEMANGIOSARCOMA	Neoplastic Lesions
No	TR-100	135-20-6	Cupferron	Rats	F344/N	Male	Dosed-Feed	Vascular System (Unspecified)	Positive	Positive	HEMANGIOSARCOMA	Neoplastic Lesions
No	TR-100	135-20-6	Cupferron	Mice	B6C3F1	Female	Dosed-Feed	Zymbal Gland	Positive	Positive	CARCINOMA	Neoplastic Lesions
No	TR-100	135-20-6	Cupferron	Rats	F344/N	Female	Dosed-Feed	Zymbal Gland	Positive	Positive	CARCINOMA	Neoplastic Lesions
No	TR-510	64-17-5	Ethanol	Mice	MV	Female	Dosed-Water	Unspecified	Inadequate Study		Not applicable	Not applicable
No	TR-510	64-17-5	Ethanol	Mice	MV	Male	Dosed-Water	Unspecified	Inadequate Study		Not applicable	Not applicable
Yes	TR-326	75-21-8	Ethylene oxide	Mice	B6C3F1	Female	Inhalation	Harderian Gland	Clear Evidence	Clear Evidence	CYSTADENOMA 1/46 6/46 8/47	Neoplastic Lesions
Yes	TR-326	75-21-8	Ethylene oxide	Mice	B6C3F1	Male	Inhalation	Harderian Gland	Clear Evidence	Clear Evidence	CYSTADENOMA 1/43 9/44 8/42	Neoplastic Lesions
No	TR-326	75-21-8	Ethylene oxide	Mice	B6C3F1	Female	Inhalation	Hematopoietic System	Clear Evidence	Clear Evidence	LYMPHOMA 9/49 6/48 22/49	Neoplastic Lesions
No	TR-326	75-21-8	Ethylene oxide	Mice	B6C3F1	Female	Inhalation	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 2/49 4/48 17/49; ALVEOLAR/BRONCHIOLAR CARCINOMA 0/49 1/48 7/49	Neoplastic Lesions
No	TR-326	75-21-8	Ethylene oxide	Mice	B6C3F1	Male	Inhalation	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 5/50 11/50 11/50; ALVEOLAR/BRONCHIOLAR CARCINOMA 6/50 10/50 16/50	Neoplastic Lesions
No	TR-326	75-21-8	Ethylene oxide	Mice	B6C3F1	Female	Inhalation	Mammary Gland	Clear Evidence	Clear Evidence	ADENOCARCINOMA 1/49 6/48 4/49; ADENOSQUAMOUS CARCINOMA 0/49 2/48 2/49	Neoplastic Lesions
No	TR-326	75-21-8	Ethylene oxide	Mice	B6C3F1	Female	Inhalation	Uterus/Cervix	Clear Evidence	Clear Evidence	ADENOCARCINOMA 0/49 1/47 5/49	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Male	Dosed-Water	All Organs	Clear Evidence	Equivocal Evidence	Mononuclear Cell Leukemia 21/48 26/48 27/48 27/47 31/48	May Have Been Related
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Female	Dosed-Water	All Organs	Clear Evidence	Clear Evidence	Mononuclear Cell Leukemia 14/48 11/48 21/48 19/48 27/48	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Female	Dosed-Water	Clitoral Gland	Clear Evidence	Clear Evidence	carcinoma 4/48 6/48 7/48 11/48 14/47	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Male	Dosed-Water	Epididymis	Clear Evidence	Clear Evidence	malignant mesothelioma 0/48 1/45 3/48 10/47 17/47	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Male	Dosed-Water	Epididymis or Testis	Clear Evidence	Clear Evidence	malignant mesothelioma 0/48 1/48 3/48 10/47 17/48	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Mice	MV	Female	Dosed-Water	Forestomach	Clear Evidence	Clear Evidence	squamous cell papilloma 1/45 1/45 1/47 5/45 9/44	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Mice	MV	Male	Dosed-Water	Forestomach	Clear Evidence	Clear Evidence	squamous cell papilloma 0/47 2/45 3/48 2/45 10/41 squamous cell carcinoma 0/47 0/45 0/48 0/45 2/41 squamous cell papilloma or carcinoma 0/47 2/45 3/48 2/45 12/41	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Female	Dosed-Water	Forestomach	Clear Evidence	Clear Evidence	squamous cell papilloma 0/48 1/48 0/48 0/47 3/46	Neoplastic Lesions
Yes	TR-588	5694-00-8	Glycidamide	Mice	MV	Female	Dosed-Water	Harderian Gland	Clear Evidence	Clear Evidence	adenoma 2/45 19/47 20/47 24/46 40/46	Neoplastic Lesions
Yes	TR-588	5694-00-8	Glycidamide	Mice	MV	Male	Dosed-Water	Harderian Gland	Clear Evidence	Clear Evidence	adenoma 3/47 17/47 23/47 32/46 42/47	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Male	Dosed-Water	Heart	Clear Evidence	Clear Evidence	malignant schwannoma 2/48 3/48 3/48 7/47 8/48	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Mice	MV	Female	Dosed-Water	Lung	Clear Evidence	Clear Evidence	alveolar/bronchiolar adenoma 3/46 5/48 3/47 7/47 9/44	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Mice	MV	Male	Dosed-Water	Lung	Clear Evidence	Clear Evidence	alveolar/bronchiolar adenoma 0/47 7/46 7/47 13/47 17/47	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Mice	MV	Female	Dosed-Water	Mammary Gland	Clear Evidence	Clear Evidence	adenoacanthoma 0/45 0/48 0/47 1/47 8/45 adenocarcinoma 1/45 1/48 2/47 9/47 11/45 adenoacanthoma or adenocarcinoma 1/45 1/48 2/47 9/47 18/45	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Female	Dosed-Water	Mammary Gland	Clear Evidence	Clear Evidence	fibroadenoma 16/48 26/48 35/48 33/48 36/48	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Female	Dosed-Water	Oral Cavity	Clear Evidence	Clear Evidence	Oral mucosa or tongue: squamous cell papilloma or carcinoma 1/48 2/48 2/48 2/48 7/48	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Female	Dosed-Water	Oral Cavity	Clear Evidence	Clear Evidence	Tongue: squamous cell papilloma 0/48 1/48 0/48 1/48 0/48 squamous cell carcinoma 0/48 0/48 0/48 0/48 1/48	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Female	Dosed-Water	Oral Cavity	Clear Evidence	Clear Evidence	Oral mucosa: squamous cell papilloma 1/48 1/48 2/48 0/48 4/48 squamous cell carcinoma 0/48 0/48 0/48 1/48 2/48	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Male	Dosed-Water	Oral Cavity	Clear Evidence	Clear Evidence	Tongue: squamous cell papilloma 0/48 1/48 0/48 1/47 4/48	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Male	Dosed-Water	Oral Cavity	Clear Evidence	Clear Evidence	Oral mucosa: squamous cell papilloma 1/48 1/48 0/48 2/47 3/48 squamous cell carcinoma 1/48 0/48 1/48 1/47 0/48	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Male	Dosed-Water	Oral Cavity	Clear Evidence	Clear Evidence	Oral mucosa or tongue: squamous cell papilloma or carcinoma 2/48 2/48 2/48 3/47 7/48	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Mice	MV	Female	Dosed-Water	Ovary	Clear Evidence	Equivocal Evidence	granulosa cell tumor – benign or malignant 0/45 0/47 0/47 3/46 3/44	May Have Been Related
No	TR-588	5694-00-8	Glycidamide	Mice	MV	Female	Dosed-Water	Skin	Clear Evidence	Clear Evidence	fibrosarcoma 0/45 1/48 2/47 2/47 9/45 sarcoma 0/45 0/48 1/47 3/47 3/45 fibrosarcoma or sarcoma 0/45 1/48 3/47 5/47 12/45	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Mice	MV	Male	Dosed-Water	Skin	Clear Evidence	Clear Evidence	squamous cell papilloma 0/47 1/48 2/47 1/47 8/46 squamous cell carcinoma 0/47 0/48 0/47 0/47 2/46 squamous cell papilloma or carcinoma 0/47 1/48 2/47 1/47 9/46	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Male	Dosed-Water	Testis	Clear Evidence	Clear Evidence	malignant mesothelioma 0/48 1/47 3/48 6/47 13/48	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Female	Dosed-Water	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	adenoma 0/48 3/48 3/46 1/46 5/47 follicular cell carcinoma 0/48 0/48 2/46 3/46 3/47 follicular cell adenoma or carcinoma 0/48 3/48 5/46 4/46 8/47	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Male	Dosed-Water	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	adenoma 2/47 1/42 3/48 3/47 8/46 follicular cell carcinoma 0/47 2/42 3/48 1/47 5/46 follicular cell adenoma or carcinoma 2/47 3/42 6/48 4/47 13/46	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Female	Gavage	Brain	Clear Evidence	Clear Evidence	GLIOMA 0/50 4/50 4/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Male	Gavage	Brain	Clear Evidence	Clear Evidence	GLIOMA 0/50 5/50 6/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Female	Gavage	Clitoral Gland	Clear Evidence	Clear Evidence	ADENOMA 3/50 7/50 7/50, ADENOCARCINOMA 0/50 1/50 0/50, OR CARCINOMA 2/50 1/50 5/50 COMBINED 5/50 9/50 12/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Male	Gavage	Epididymis	Clear Evidence	Equivocal Evidence	SARCOMA 0/50 0/50 2/50	May Have Been Related
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Male	Gavage	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 2/50 9/50 OR SQUAMOUS CELL CARCINOMA 1/50 0/50 1/50 COMBINED 1/50 2/50 10/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Female	Gavage	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 4/50 8/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 3/50 COMBINED 0/50 4/50 11/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Male	Gavage	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 1/50 5/50 OR SQUAMOUS CELL CARCINOMA 1/50 1/50 2/50 COMBINED 1/50 2/50 6/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Female	Gavage	Glandular Stomach	Clear Evidence	Equivocal Evidence	FIBROSARCOMA 0/50 0/50 2/50	May Have Been Related
Yes	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Female	Gavage	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 4/50 10/50 16/50 OR ADENOCARCINOMA 0/50 1/50 1/50 COMBINED 4/50 11/50 17/50	Neoplastic Lesions
Yes	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Male	Gavage	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 7/50 10/50 16/50 OR ADENOCARCINOMA 1/50 2/50 7/50 COMBINED 8/50 12/50 22/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Female	Gavage	Hematopoietic System	Clear Evidence	Clear Evidence	LEUKEMIA 13/50 14/50 20/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Male	Gavage	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMATOUS POLYP 0/50 0/50 1/50 OR ADENOCARCINOMA 0/50 1/50 3/50 COMBINED 0/50 1/50 4/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Male	Gavage	Liver	Clear Evidence	Clear Evidence	ADENOMA 18/50 16/50 30/50 OR CARCINOMA 10/50 17/50 8/50 COMBINED 24/50 31/50 35/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Male	Gavage	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 6/50 6/50 8/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 7/50 5/50 14/50 COMBINED 13/50 11/50 21/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Female	Gavage	Mammary Gland	Clear Evidence	Clear Evidence	ADENOMA 0/50 1/50 0/50, FIBROADENOMA 1/50 0/50 0/50, OR ADENOCARCINOMA 1/50 5/50 15/50 COMBINED 2/50 6/50 15/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Female	Gavage	Mammary Gland	Clear Evidence	Clear Evidence	FIBROADENOMA 14/50 32/50 29/50; ADENOCARCINOMA 1/50 11/50 16/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Male	Gavage	Mammary Gland	Clear Evidence	Clear Evidence	FIBROADENOMA 3/50 8/50 7/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Male	Gavage	Mesothelium (Abdominal Cavity/Tunica Vaginalis)	Clear Evidence	Clear Evidence	MESOTHELIOMA 3/50 34/50 39/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Female	Gavage	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 1/50 3/50 6/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 1/50 COMBINED 1/50 3/50 7/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Female	Gavage	Skin	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 0/50 1/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 1/50 COMBINED 0/50 0/50 2/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Male	Gavage	Skin	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 0/50 4/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Male	Gavage	Skin	Clear Evidence	Clear Evidence	SEBACEOUS GLAND ADENOMA 0/50 0/50 1/50, BASAL CELL CARCINOMA 0/50 4/50 2/50, OR SEBACEOUS GLAND ADENOCARCINOMA 0/50 0/50 1/50 COMBINED 0/50 5/50 4/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Female	Gavage	Subcutaneous Tissue	Clear Evidence	Clear Evidence	SARCOMA 0/50 1/50 6/50 OR FIBROSARCOMA 0/50 2/50 3/50 COMBINED 0/50 3/50 9/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Female	Gavage	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 1/50 0/49 OR CARCINOMA 0/50 0/50 3/49 COMBINED 0/50 1/50 3/49	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Male	Gavage	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 2/50 2/50 OR CARCINOMA 1/50 2/50 5/50 COMBINED 1/50 4/50 6/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Male	Gavage	Urinary Bladder	Clear Evidence	Equivocal Evidence	CARCINOMA 0/50 1/50 1/50	May Have Been Related
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Female	Gavage	Uterus/Cervix	Clear Evidence	Clear Evidence	CARCINOMA 0/50 0/50 1/50 OR ADENOCARCINOMA 0/50 3/50 2/50 COMBINED 0/50 3/50 3/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Male	Gavage	Zymbal Gland	Clear Evidence	Clear Evidence	CARCINOMA 1/50 3/50 6/50	Neoplastic Lesions
No	TR-340	5634-39-9	Iodinated glycerol	Mice	B6C3F1	Female	Gavage	Forestomach	Some Evidence	Equivocal Evidence	SQUAMOUS CELL PAPILLOMA 1/49 2/50 5/49	May Have Been Related
Yes	TR-340	5634-39-9	Iodinated glycerol	Mice	B6C3F1	Female	Gavage	Harderian Gland	Some Evidence	Some Evidence	ADENOMA 6/50 8/40 13/50 OR CARCINOMA 0/50 0/40 1/50 COMBINED 6/50 8/40 14/50	Neoplastic Lesions
No	TR-340	5634-39-9	Iodinated glycerol	Rats	F344/N	Male	Gavage	Hematopoietic System	Some Evidence	Some Evidence	LEUKEMIA 14/50 29/50 24/50	Neoplastic Lesions
No	TR-340	5634-39-9	Iodinated glycerol	Rats	F344/N	Male	Gavage	Nasal Cavity	Some Evidence	Equivocal Evidence	ADENOMA 0/48 0/47 2/49	May Have Been Related
No	TR-340	5634-39-9	Iodinated glycerol	Mice	B6C3F1	Female	Gavage	Pituitary Gland	Some Evidence	Some Evidence	ADENOMA 10/47 15/45 24/46	Neoplastic Lesions
No	TR-340	5634-39-9	Iodinated glycerol	Rats	F344/N	Male	Gavage	Thyroid Gland Follicular Cell	Some Evidence	Some Evidence	CARCINOMA 0/49 5/49 1/49	Neoplastic Lesions
No	TR-352	924-42-5	N-Methylolacrylamide	Rats	F344/N	Female	Gavage	Unspecified	No Evidence		Not applicable	Not applicable
No	TR-352	924-42-5	N-Methylolacrylamide	Rats	F344/N	Male	Gavage	Unspecified	No Evidence		Not applicable	Not applicable
Yes	TR-352	924-42-5	N-Methylolacrylamide	Mice	B6C3F1	Female	Gavage	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 5/47 8/45 20/48	Neoplastic Lesions
Yes	TR-352	924-42-5	N-Methylolacrylamide	Mice	B6C3F1	Male	Gavage	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 1/48 14/49 29/50	Neoplastic Lesions
No	TR-352	924-42-5	N-Methylolacrylamide	Mice	B6C3F1	Female	Gavage	Liver	Clear Evidence	Clear Evidence	ADENOMA 3/50 4/50 17/49	Neoplastic Lesions
No	TR-352	924-42-5	N-Methylolacrylamide	Mice	B6C3F1	Male	Gavage	Liver	Clear Evidence	Clear Evidence	ADENOMA 8/50 4/50 19/50 OR CARCINOMA 6/50 13/50 12/50 COMBINED 12/50 17/50 26/50	Neoplastic Lesions
No	TR-352	924-42-5	N-Methylolacrylamide	Mice	B6C3F1	Female	Gavage	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 4/50 4/50 7/49 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 2/50 5/50 7/49 COMBINED 6/50 8/50 13/49	Neoplastic Lesions
No	TR-352	924-42-5	N-Methylolacrylamide	Mice	B6C3F1	Male	Gavage	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 3/49 6/50 11/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 2/49 4/50 10/50 COMBINED 5/49 10/50 18/50	Neoplastic Lesions
No	TR-352	924-42-5	N-Methylolacrylamide	Mice	B6C3F1	Female	Gavage	Ovary	Clear Evidence	Clear Evidence	GRANULOSA CELL TUMOR 0/50 5/45 5/47	Neoplastic Lesions
No	TR-461	75-52-5	Nitromethane	Rats	F344/N	Male	Inhalation	Unspecified	No Evidence		Not applicable	Not applicable
Yes	TR-461	75-52-5	Nitromethane	Mice	B6C3F1	Female	Inhalation	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 5/50 7/50 16/50 19/50 OR CARCINOMA 1/50 2/50 4/50 3/50 COMBINED 6/50 9/50 20/50 21/50	Neoplastic Lesions
Yes	TR-461	75-52-5	Nitromethane	Mice	B6C3F1	Male	Inhalation	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 9/50 10/50 19/50 32/50 OR CARCINOMA 1/50 1/50 6/50 5/50 COMBINED 10/50 11/50 25/50 37/50	Neoplastic Lesions
No	TR-461	75-52-5	Nitromethane	Mice	B6C3F1	Female	Inhalation	Liver	Clear Evidence	Clear Evidence	ADENOMA 14/50 25/50 17/50 35/50 OR CARCINOMA 10/50 14/50 8/50 12/50 COMBINED 19/50 34/50 22/50 40/50	Neoplastic Lesions
No	TR-461	75-52-5	Nitromethane	Mice	B6C3F1	Female	Inhalation	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 3/50 3/50 2/50 9/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 3/50 5/50 3/50 COMBINED 3/50 6/50 6/50 12/50	Neoplastic Lesions
No	TR-461	75-52-5	Nitromethane	Mice	B6C3F1	Male	Inhalation	Lung	Clear Evidence	Clear Evidence	ALVEOLAR ADENOMA 11/50 10/50 9/50 12/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 2/50 3/50 3/50 11/50 COMBINED 13/50 13/50 12/50 20/50	Neoplastic Lesions
No	TR-461	75-52-5	Nitromethane	Rats	F344/N	Female	Inhalation	Mammary Gland	Clear Evidence	Clear Evidence	FIBROADENOMA 19/50 21/50 33/50 36/50 OR CARCINOMA 2/50 7/50 1/50 11/50 COMBINED 9/50 25/50 34/50 39/50	Neoplastic Lesions
No	TR-594	98-56-6	p-Chloro-a,a,a-trifluorotoluene	Rats	Harlan Sprague-Dawley	Female	Inhalation	Adrenal Gland Medulla	Some Evidence	Some Evidence	benign pheochromocytoma (0/49, 3/50, 4/50, 6/50)	Neoplastic Lesions
Yes	TR-594	98-56-6	p-Chloro-a,a,a-trifluorotoluene	Mice	B6C3F1	Female	Inhalation	Harderian Gland	Clear Evidence	Clear Evidence	adenoma (2/50, 6/50, 6/50, 8/50); adenoma or adenocarcinoma (2/50, 6/50, 9/50, 8/50)	Neoplastic Lesions
No	TR-594	98-56-6	p-Chloro-a,a,a-trifluorotoluene	Mice	B6C3F1	Female	Inhalation	Liver	Clear Evidence	Clear Evidence	hepatocellular adenoma (12/50, 14/50, 24/50, 34/50); hepatocellular carcinoma (7/50, 8/50, 12/50, 34/50); hepatoblastoma (0/50, 0/50, 1/50, 8/50)	Neoplastic Lesions
No	TR-594	98-56-6	p-Chloro-a,a,a-trifluorotoluene	Mice	B6C3F1	Male	Inhalation	Liver	Clear Evidence	Clear Evidence	hepatocellular carcinoma (8/50, 19/50, 16/50, 35/50); hepatoblastoma (1/50, 1/50, 1/50, 15/50)	Neoplastic Lesions
No	TR-594	98-56-6	p-Chloro-a,a,a-trifluorotoluene	Rats	Harlan Sprague-Dawley	Male	Inhalation	Lung	Some Evidence	Equivocal Evidence	alveolar/bronchiolar adenoma or carcinoma (0/50, 2/50, 0/50, 3/50)	May Have Been Related
No	TR-594	98-56-6	p-Chloro-a,a,a-trifluorotoluene	Rats	Harlan Sprague-Dawley	Female	Inhalation	Thyroid Gland C-Cell	Some Evidence	Some Evidence	adenoma (2/50, 8/50, 8/50, 14/50)	Neoplastic Lesions
No	TR-594	98-56-6	p-Chloro-a,a,a-trifluorotoluene	Rats	Harlan Sprague-Dawley	Male	Inhalation	Thyroid Gland C-Cell	Some Evidence	Some Evidence	adenoma (2/50, 5/49, 3/49, 12/50)	Neoplastic Lesions
No	TR-594	98-56-6	p-Chloro-a,a,a-trifluorotoluene	Rats	Harlan Sprague-Dawley	Female	Inhalation	Uterus	Some Evidence	Some Evidence	adenocarcinoma (1/50, 1/50, 0/50, 5/50); stromal polyp (7/50, 9/50, 16/50, 12/50)	Neoplastic Lesions
Yes	TR-552	107-19-7	Propargyl alcohol	Mice	B6C3F1/N	Male	Inhalation	Harderian Gland	Some Evidence	Equivocal Evidence	adenoma 3/50, 10/50, 6/50, 11/50	May Have Been Related
No	TR-552	107-19-7	Propargyl alcohol	Mice	B6C3F1/N	Female	Inhalation	Nasal Cavity	Some Evidence	Some Evidence	adenoma, respiratory epithelium (0/50, 2/50, 4/50, 6/50)	Neoplastic Lesions
No	TR-552	107-19-7	Propargyl alcohol	Mice	B6C3F1/N	Male	Inhalation	Nasal Cavity	Some Evidence	Some Evidence	adenoma, respiratory epithelium (0/49, 1/50, 4/50, 7/50)	Neoplastic Lesions
No	TR-552	107-19-7	Propargyl alcohol	Rats	F344/N	Male	Inhalation	Nasal Cavity	Some Evidence	Some Evidence	adenoma, respiratory epithelium (0/49, 0/49, 0/50, 3/49)	Neoplastic Lesions
No	TR-510	51-79-6	Urethane	Mice	MV	Male	Dosed-Water	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA OR SQUAMOUS CELL CARCINOMA 0/46 2/47 3/44 5/45	Neoplastic Lesions
Yes	TR-510	51-79-6	Urethane	Mice	MV	Female	Dosed-Water	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 3/48 10/48 8/48 21/48 CARCINOMA 0/48 1/48 11/48 11/48 COMBINED 3/48 11/48 19/48 30/48	Neoplastic Lesions
Yes	TR-510	51-79-6	Urethane	Mice	MV	Male	Dosed-Water	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 3/47 11/47 25/47 28/47 CARCINOMA 0/47 1/47 7/47 16/47 COMBINED 3/47 12/47 30/47 38/47	Neoplastic Lesions
No	TR-510	51-79-6	Urethane	Mice	MV	Male	Dosed-Water	Heart	Clear Evidence	Clear Evidence	HEMANGIOSARCOMA 0/48 0/48 1/47 5/48	Neoplastic Lesions
No	TR-510	51-79-6	Urethane	Mice	MV	Female	Dosed-Water	Liver	Clear Evidence	Clear Evidence	HEMANGIOSARCOMA 0/48 0/47 1/47 7/47 ADENOMA 5/48 10/47 19/47 18/47 ADENOMA OR CARCINOMA 5/48 11/47 20/47 19/47	Neoplastic Lesions
No	TR-510	51-79-6	Urethane	Mice	MV	Male	Dosed-Water	Liver	Clear Evidence	Clear Evidence	HEMANGIOSARCOMA 1/46 2/47 5/46 13/44 ADENOMA 7/46 13/47 17/46 17/44 ADENOMA OR CARCINOMA 12/46 18/47 24/46 23/44	Neoplastic Lesions
No	TR-510	51-79-6	Urethane	Mice	MV	Female	Dosed-Water	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 4/48 6/48 17/48 29/47 ALVEOLAR/BRONCHIOLAR CARCINOMA 2/48 4/48 13/48 19/47 COMBINED 6/48 8/48 28/48 39/47	Neoplastic Lesions
No	TR-510	51-79-6	Urethane	Mice	MV	Male	Dosed-Water	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 4/48 17/48 22/47 34/48 ALVEOLAR/BRONCHIOLAR CARCINOMA 1/48 1/48 9/47 9/48 COMBINED 5/48 18/48 29/47 37/48	Neoplastic Lesions
No	TR-510	51-79-6	Urethane	Mice	MV	Female	Dosed-Water	Mammary Gland	Clear Evidence	Clear Evidence	ADENOACANTHOMA 0/47 1/46 1/46 11/48 ADENOCARCINOMA 4/47 3/46 3/46 11/48 COMBINED 4/47 4/46 4/46 22/48	Neoplastic Lesions
No	TR-510	51-79-6	Urethane	Mice	MV	Female	Dosed-Water	Ovary	Clear Evidence	Clear Evidence	BENIGN GRANULOSA CELL TUMOR 0/48 0/46 2/46 3/39 MALIGNANT GRANULOSA CELL TUMOR 0/48 0/46 0/46 3/39 COMBINED 0/48 0/46 2/46 5/39	Neoplastic Lesions
No	TR-510	51-79-6	Urethane	Mice	MV	Female	Dosed-Water	Skin	Clear Evidence	Clear Evidence	HEMANGIOSARCOMA 0/48 0/48 0/46 2/48	Neoplastic Lesions
No	TR-510	51-79-6	Urethane	Mice	MV	Male	Dosed-Water	Skin	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA OR SQUAMOUS CELL CARCINOMA (0/47, 1/48, 5/47, 8/48)	Neoplastic Lesions
No	TR-510	51-79-6	Urethane	Mice	MV	Female	Dosed-Water	Spleen	Clear Evidence	Clear Evidence	HEMANGIOSARCOMA 0/48 0/45 1/47 4/46	Neoplastic Lesions
No	TR-510	51-79-6	Urethane	Mice	MV	Female	Dosed-Water	Uterus/Cervix	Clear Evidence	Clear Evidence	HEMANGIOSARCOMA 0/48 0/47 0/48 2/46	Neoplastic Lesions
Yes	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Female	Dosed-Water	Harderian Gland	Clear Evidence	Clear Evidence	(URETHANE AND 5% ETHANOL) ADENOMA 4/48 7/48 6/46 20/46 CARCINOMA 1/48 11/48 7/46 10/46 COMBINED 5/48 18/48 13/46 29/46	Neoplastic Lesions
Yes	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Female	Dosed-Water	Harderian Gland	Clear Evidence	Clear Evidence	(URETHANE AND 2.5% ETHANOL) ADENOMA 2/47 3/47 9/46 19/47 CARCINOMA 1/47 3/47 6/46 16/47 COMBINED 3/47 5/47 15/46 35/47	Neoplastic Lesions
Yes	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Male	Dosed-Water	Harderian Gland	Clear Evidence	Clear Evidence	(URETHANE AND 5% ETHANOL) ADENOMA 5/47 12/48 15/48 26/45 CARCINOMA 0/47 2/48 2/48 10/45 COMBINED 5/47 14/48 17/48 35/45	Neoplastic Lesions
Yes	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Male	Dosed-Water	Harderian Gland	Clear Evidence	Clear Evidence	(URETHANE AND 2.5% ETHANOL) ADENOMA 6/48 14/48 21/47 27/48 CARCINOMA 0/48 0/48 1/47 16/48 COMBINED 6/48 14/48 21/47 38/48	Neoplastic Lesions
No	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Female	Dosed-Water	Heart	Clear Evidence	Clear Evidence	(URETHANE AND 2.5% ETHANOL) HEMANGIOSARCOMA 0/47 0/47 0/48 3/48	Neoplastic Lesions
No	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Female	Dosed-Water	Heart	Clear Evidence	Clear Evidence	(URETHANE AND 5% ETHANOL) HEMANGIOSARCOMA 0/47 0/48 0/48 6/47	Neoplastic Lesions
No	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Male	Dosed-Water	Heart	Clear Evidence	Clear Evidence	(URETHANE AND 2.5% ETHANOL) HEMANGIOSARCOMA 0/48 0/48 2/47 4/48	Neoplastic Lesions
No	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Male	Dosed-Water	Heart	Clear Evidence	Clear Evidence	(URETHANE AND 5% ETHANOL) HEMANGIOSARCOMA 0/47 0/48 1/48 4/48	Neoplastic Lesions
No	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Female	Dosed-Water	Liver	Clear Evidence	Clear Evidence	(URETHANE AND 2.5% ETHANOL) HEMANGIOSARCOMA 1/47 2/47 0/47 7/46 ADENOMA 6/47 5/47 15/47 23/46 ADENOMA OR CARCINOMA 7/47 5/47 16/47 23/46	Neoplastic Lesions
No	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Female	Dosed-Water	Liver	Clear Evidence	Clear Evidence	(URETHANE AND 5% ETHANOL) HEMANGIOSARCOMA 0/48 0/47 0/48 6/48 ADENOMA 3/48 6/47 16/48 16/48 ADENOMA OR CARCINOMA 3/48 7/47 16/48 17/48	Neoplastic Lesions
No	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Male	Dosed-Water	Liver	Clear Evidence	Clear Evidence	(URETHANE AND 2.5% ETHANOL) HEMANGIOSARCOMA 3/47 4/48 3/46 11/48 ADENOMA 12/47 15/48 16/46 24/48 ADENOMA OR CARCINOMA 16/47 19/48 17/46 24/48	Neoplastic Lesions
No	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Male	Dosed-Water	Liver	Clear Evidence	Clear Evidence	(URETHANE AND 5% ETHANOL) HEMANGIOSARCOMA 2/48 2/46 4/48 13/48	Neoplastic Lesions
No	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Female	Dosed-Water	Lung	Clear Evidence	Clear Evidence	(URETHANE AND 2.5% ETHANOL) ALVEOLAR/BRONCHIOLAR ADENOMA 5/47 10/47 16/48 28/48 ALVEOLAR/BRONCHIOLAR CARCINOMA 0/47 2/47 6/48 23/48 COMBINED 5/47 11/47 21/48 38/48	Neoplastic Lesions
No	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Female	Dosed-Water	Lung	Clear Evidence	Clear Evidence	(URETHANE AND 5% ETHANOL) ALVEOLAR/BRONCHIOLAR ADEMONA 5/48 10/48 18/48 30/48 ALVEOLAR/BRONCHIOLAR CARCINOMA 1/48 7/48 9/48 23/48 COMBINED 5/48 17/48 24/48 37/48	Neoplastic Lesions
No	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Male	Dosed-Water	Lung	Clear Evidence	Clear Evidence	(URETHANE AND 2.5% ETHANOL) ALVEOLAR/BRONCHIOLAR ADENOMA 10/48 16/48 19/47 35/48 ALVEOLAR/BRONCHIOLAR CARCINOMA 2/48 3/48 8/47 24/48 COMBINED 11/48 19/48 24/47 43/48	Neoplastic Lesions
No	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Male	Dosed-Water	Lung	Clear Evidence	Clear Evidence	(URETHANE AND 5% ETHANOL) ALVEOLAR/BRONCHIOLAR ADEMONA 6/48 8/48 9/48 33/48 ALVEOLAR/BRONCHIOLAR CARCINOMA 5/48 4/48 5/48 17/48 COMBINED 11/48 11/48 14/48 40/48	Neoplastic Lesions
No	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Female	Dosed-Water	Mammary Gland	Clear Evidence	Clear Evidence	(URETHANE AND 2.5% ETHANOL) ADENOACANTHOMA 0/47 0/45 2/48 3/47 ADENOCARCINOMA 4/47 3/45 11/48 14/47 COMBINED 4/47 3/45 12/48 16/47	Neoplastic Lesions
No	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Female	Dosed-Water	Mammary Gland	Clear Evidence	Clear Evidence	(URETHANE AND 5% ETHANOL) ADENOACANTHOMA 0/47 0/48 1/48 9/45 ADENOCARCINOMA 3/47 4/48 6/48 15/45 COMBINED 3/47 4/48 7/48 23/45	Neoplastic Lesions
No	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Female	Dosed-Water	Ovary	Clear Evidence	Clear Evidence	(URETHANE AND 5% ETHANOL) BENIGN GRANULOSA CELL TUMOR 0/46 0/47 5/46 3/45 BENIGN OR MALIGNANT GRANULOSA CELL TUMOR 0/46 0/47 6/46 3/45	Neoplastic Lesions
No	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Female	Dosed-Water	Skin	Clear Evidence	Clear Evidence	(URETHANE AND 2.5% ETHANOL) HEMANGIOSARCOMA 0/47 0/47 0/48 2/47	Neoplastic Lesions
No	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Male	Dosed-Water	Skin	Clear Evidence	Clear Evidence	(URETHANE AND 5% ETHANOL) SQUAMOUS CELL PAPILLOMA OR SQUAMOUS CELL CARCINOMA (0/48, 2/47, 0/48, 7/48)	Neoplastic Lesions
No	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Male	Dosed-Water	Skin	Clear Evidence	Clear Evidence	(URETHANE AND 2.5% ETHANOL) SQUAMOUS CELL PAPILLOMA OR SQUAMOUS CELL CARCINOMA (0/48, 1/48, 4/46, 7/47)	Neoplastic Lesions
No	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Female	Dosed-Water	Spleen	Clear Evidence	Clear Evidence	(URETHANE AND 2.5% ETHANOL) HEMANGIOSARCOMA 0/47 0/46 0/46 3/46	Neoplastic Lesions
No	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Male	Dosed-Water	Spleen	Clear Evidence	Clear Evidence	(URETHANE AND 2.5% ETHANOL) HEMANGIOSARCOMA 0/46 0/46 1/46 3/46	Neoplastic Lesions
No	TR-583	71133-14-7	Water disinfection byproducts (Bromodichloroacetic Acid)	Rats	F344/NTac	Male	Dosed-Water	All Organs	Clear Evidence	Clear Evidence	malignant mesothelioma 1/50 12/50 18/50 37/50	Neoplastic Lesions
No	TR-583	71133-14-7	Water disinfection byproducts (Bromodichloroacetic Acid)	Rats	F344/NTac	Female	Dosed-Water	Brain	Clear Evidence	Equivocal Evidence	glioma or oligodendroglioma (original and extended evaluations combined): 0/50 1/50 3/50 1/50	May Have Been Related
No	TR-583	71133-14-7	Water disinfection byproducts (Bromodichloroacetic Acid)	Rats	F344/NTac	Male	Dosed-Water	Brain	Clear Evidence	Equivocal Evidence	glioma or oligodendroglioma (original and extended evaluations combined): 0/50 1/50 4/50 3/50	May Have Been Related
Yes	TR-583	71133-14-7	Water disinfection byproducts (Bromodichloroacetic Acid)	Mice	B6C3F1/N	Male	Dosed-Water	Harderian Gland	Clear Evidence	Clear Evidence	adenoma 6/50 11/50 14/49 19/51 adenoma or carcinoma 6/50 11/50 14/49 20/51	Neoplastic Lesions
No	TR-583	71133-14-7	Water disinfection byproducts (Bromodichloroacetic Acid)	Mice	B6C3F1/N	Female	Dosed-Water	Liver	Clear Evidence	Clear Evidence	hepatocellular adenoma 33/49 42/50 42/49 44/50 hepatocellular carcinoma 9/49 17/50 22/49 26/50 hepatoblastoma 0/49 1/50 4/49 6/50 hepatocellular adenoma, hepatocellular carcinoma, or hepatoblastoma 36/49 44/50 43/49 46/50	Neoplastic Lesions
No	TR-583	71133-14-7	Water disinfection byproducts (Bromodichloroacetic Acid)	Mice	B6C3F1/N	Male	Dosed-Water	Liver	Clear Evidence	Clear Evidence	hepatocellular carcinoma 12/50 22/50 27/49 39/51 hepatoblastoma 4/50 24/50 40/49 34/51	Neoplastic Lesions
No	TR-583	71133-14-7	Water disinfection byproducts (Bromodichloroacetic Acid)	Rats	F344/NTac	Female	Dosed-Water	Mammary Gland	Clear Evidence	Clear Evidence	fibroadenoma 28/50 47/50 47/50 39/50 carcinoma 0/50 1/50 3/50 8/50 fibroadenoma, adenoma, or carcinoma 28/50 47/50 48/50 42/50	Neoplastic Lesions
No	TR-583	71133-14-7	Water disinfection byproducts (Bromodichloroacetic Acid)	Rats	F344/NTac	Male	Dosed-Water	Oral Cavity	Clear Evidence	Equivocal Evidence	(oral mucosa and tongue): squamous cell papilloma or squamous cell carcinoma 1/50 0/50 3/50 3/50	May Have Been Related
No	TR-583	71133-14-7	Water disinfection byproducts (Bromodichloroacetic Acid)	Rats	F344/NTac	Male	Dosed-Water	Skin	Clear Evidence	Clear Evidence	squamous cell papilloma, keratoacanthoma, sebaceous gland adenoma, basal cell adenoma, basal cell carcinoma, or squamous cell carcinoma 9/50 7/50 15/50 21/50	Neoplastic Lesions
No	TR-583	71133-14-7	Water disinfection byproducts (Bromodichloroacetic Acid)	Rats	F344/NTac	Male	Dosed-Water	Skin	Clear Evidence	Clear Evidence	(subcutaneous tissue): fibroma 4/50 6/50 10/50 15/50	Neoplastic Lesions