Search Results

One moment please while the data are loaded...

The DNTP Technical Report (TR) Level of Evidence Criteria are available here: https://ntp.niehs.nih.gov/go/baresults. In the table below this information is further delineated into three fields:

Level of Evidence: The overall category of evidence of carcinogenic activity for the TR, Species, Strain and Sex
Organ Site Call: The level of evidence supported by the specific organ site for the TR, Species, Strain and Sex. When the Organ Site Call directly supports the TR Level Of Evidence the Finding Type flag is set to “Neoplastic Lesion”. Some Organ Site Calls could support a separate call of Equivocal Evidence; this is noted in Finding Type by the flag “May Have Been Related”
Finding Type: Further identification of the Organ Site Call. Where this says “Neoplastic Lesion” the Organ Site Call supports the TR Level of Evidence and the Organ Site Call is the same as that of the TR. Where Finding Type says “May Have Been Related” the TR Level of Evidence for other responses led to an overall call of Clear or Some Evidence but the specified organ supports a call of Equivocal Evidence.

Displays results that match exactly with the given criteria.
Exact Match	Publication No.	CASRN	Test Article Name	Species	Strain	Sex	Route	Organ	Level of Evidence	Organ Site Call	Tumor Type/Incidence	Finding Type
Yes	TR-059	22966-79-6	Estradiol mustard	Mice	B6C3F1	Female	Gavage	Heart	Positive	Positive	(SARCOMA)	Neoplastic Lesions
Yes	TR-059	22966-79-6	Estradiol mustard	Mice	B6C3F1	Male	Gavage	Heart	Positive	Positive	(SARCOMA)	Neoplastic Lesions
Yes	TR-060	3546-10-9	Phenesterin	Mice	B6C3F1	Female	Gavage	Heart	Positive	Positive	(SARCOMA)	Neoplastic Lesions
Yes	TR-060	3546-10-9	Phenesterin	Mice	B6C3F1	Male	Gavage	Heart	Positive	Positive	(SARCOMA)	Neoplastic Lesions
Yes	TR-510	51-79-6	Urethane	Mice	MV	Male	Dosed-Water	Heart	Clear Evidence	Clear Evidence	HEMANGIOSARCOMA 0/48 0/48 1/47 5/48	Neoplastic Lesions
Yes	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Female	Dosed-Water	Heart	Clear Evidence	Clear Evidence	(URETHANE AND 2.5% ETHANOL) HEMANGIOSARCOMA 0/47 0/47 0/48 3/48	Neoplastic Lesions
Yes	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Female	Dosed-Water	Heart	Clear Evidence	Clear Evidence	(URETHANE AND 5% ETHANOL) HEMANGIOSARCOMA 0/47 0/48 0/48 6/47	Neoplastic Lesions
Yes	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Male	Dosed-Water	Heart	Clear Evidence	Clear Evidence	(URETHANE AND 2.5% ETHANOL) HEMANGIOSARCOMA 0/48 0/48 2/47 4/48	Neoplastic Lesions
Yes	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Male	Dosed-Water	Heart	Clear Evidence	Clear Evidence	(URETHANE AND 5% ETHANOL) HEMANGIOSARCOMA 0/47 0/48 1/48 4/48	Neoplastic Lesions
Yes	TR-595	CELLPRADCDMA	Cell Phone Radiation: CDMA	Rats	Hsd:Sprague Dawley SD	Male	Whole Body Exposure	Heart	Clear Evidence	Clear Evidence	schwannoma malignant (0/90, 2/90, 3/90, 6/90)	Neoplastic Lesions
Yes	TR-595	CELLPRADGSM	Cell Phone Radiation: GSM	Rats	Hsd:Sprague Dawley SD	Male	Whole Body Exposure	Heart	Clear Evidence	Clear Evidence	schwannoma malignant (0/90, 2/90, 1/90, 5/90)	Neoplastic Lesions
Yes	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Male	Dosed-Water	Heart	Clear Evidence	Clear Evidence	malignant Schwannoma 1/48 2/48 3/48 4/48 6/48	Neoplastic Lesions
Yes	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Male	Dosed-Water	Heart	Clear Evidence	Clear Evidence	malignant schwannoma 2/48 3/48 3/48 7/47 8/48	Neoplastic Lesions
Yes	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Female	Dosed-Water	Heart	Clear Evidence	Clear Evidence	malignant Schwannoma 2/48 1/48 0/48 2/48 4/48	Neoplastic Lesions

Displays all results in TRs which have data that match the given criteria.
Exact Match	Publication No.	CASRN	Test Article Name	Species	Strain	Sex	Route	Organ	Level of Evidence	Organ Site Call	Tumor Type/Incidence	Finding Type
No	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Female	Dosed-Water	Clitoral Gland	Clear Evidence	Clear Evidence	carcinoma 1/4 6/48 12/47 3/48 8/47	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Male	Dosed-Water	Epididymis	Clear Evidence	Clear Evidence	malignant mesothelioma 2/48 2/48 1/48 5/48 8/48	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Male	Dosed-Water	Epididymis or Testis	Clear Evidence	Clear Evidence	malignant mesothelioma 2/48 2/48 1/48 5/48 8/48	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Mice	MV	Female	Dosed-Water	Forestomach	Clear Evidence	Clear Evidence	squamous cell papilloma 4/46 0/46 2/48 5/45 8/42	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Mice	MV	Male	Dosed-Water	Forestomach	Clear Evidence	Clear Evidence	squamous cell papilloma 0/46 2/45 2/46 6/47 6/44 squamous cell carcinoma 0/46 0/45 0/46 1/47 2/44 squamous cell papilloma or carcinoma 0/46 2/45 2/46 7/47 8/44	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Mice	MV	Female	Dosed-Water	Harderian Gland	Clear Evidence	Clear Evidence	adenoma 0/45 8/44 20/48 32/47 31/43	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Mice	MV	Male	Dosed-Water	Harderian Gland	Clear Evidence	Clear Evidence	adenoma 2/46 13/46 27/47 36/47 39/47 adenocarcinoma 0/46 0/46 0/47 1/47 1/47 adenoma or adenocarcinoma 2/46 13/46 27/47 37/47 39/47	Neoplastic Lesions
Yes	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Female	Dosed-Water	Heart	Clear Evidence	Clear Evidence	malignant Schwannoma 2/48 1/48 0/48 2/48 4/48	Neoplastic Lesions
Yes	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Male	Dosed-Water	Heart	Clear Evidence	Clear Evidence	malignant Schwannoma 1/48 2/48 3/48 4/48 6/48	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Female	Dosed-Water	Liver	Clear Evidence	Clear Evidence	adenoma 0/48 0/48 1/48 1/48 3/48	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Mice	MV	Female	Dosed-Water	Lung	Clear Evidence	Clear Evidence	alveolar/bronchiolar adenoma 1/47 4/47 6/48 11/45 19/45	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Mice	MV	Male	Dosed-Water	Lung	Clear Evidence	Clear Evidence	alveolar/bronchiolar adenoma 5/47 6/46 13/47 10/45 19/48 alveolar/bronchiolar adenoma or carcinoma 6/47 6/46 14/47 10/45 20/48	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Mice	MV	Female	Dosed-Water	Mammary Gland	Clear Evidence	Clear Evidence	adenoacanthoma 0/47 1/46 1/48 2/45 4/42 adenocarcinoma 0/47 4/46 6/48 2/45 13/42 adenoacanthoma or adenocarcinoma 0/47 4/46 7/48 4/45 17/42	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Female	Dosed-Water	Mammary Gland	Clear Evidence	Clear Evidence	fibroadenoma 16/48 18/48 24/46 22/47 31/48	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Female	Dosed-Water	Oral Cavity	Clear Evidence	Clear Evidence	squamous cell papilloma or carcinoma 0/48 2/48 1/48 3/48 5/48	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Mice	MV	Female	Dosed-Water	Ovary	Clear Evidence	Clear Evidence	benign granulose cell tumor 0/46 1/45 0/48 1/45 5/42	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Male	Dosed-Water	Pancreas Islet Cell	Clear Evidence	Clear Evidence	adenoma 1/46 2/48 4/48 1/48 6/48 carcinoma 0/46 0/48 0/48 1/48 0/48 adenoma or carcinoma 1/46 2/48 4/48 2/48 6/48	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Mice	MV	Female	Dosed-Water	Skin	Clear Evidence	Clear Evidence	fibrosarcoma, fibrous histocytoma, myxosarcoma, neurofibrosarcoma, or sarcoma 0/48 0/46 3/48 10/45 6/43 squamous cell carcinoma 0/48 0/46 0/48 0/45 2/43	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Female	Dosed-Water	Skin	Clear Evidence	Clear Evidence	subcutaneous tissue fibroma, fibrosarcoma or sarcoma 1/48 0/48 0/48 1/48 5/48	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Male	Dosed-Water	Testis	Clear Evidence	Clear Evidence	malignant mesothelioma 1/48 2/48 1/48 1/48 5/48	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Female	Dosed-Water	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	adenoma 0/48 0/48 1/48 0/48 2/47 carcinoma 0/48 0/48 1/48 3/48 2/47 adenoma or carcinoma 0/48 0/48 2/48 3/48 4/47	Neoplastic Lesions
No	TR-575	79-06-1	Acrylamide	Rats	F344 (NCTR)	Male	Dosed-Water	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	adenoma 0/47 1/48 1/47 1/48 3/48 carcinoma 1/47 2/48 3/47 6/48 6/48 l adenoma or carcinoma 1/47 3/48 4/47 6/48 9/48	Neoplastic Lesions
No	TR-595	CELLPRADCDMA	Cell Phone Radiation: CDMA	Rats	Hsd:Sprague Dawley SD	Female	Whole Body Exposure	Adrenal Gland Medulla	Equivocal Evidence	Equivocal Evidence	benign, malignant, or complex pheochromocytoma (1/86, 9/89, 5/87, 4/88)	May Have Been Related
No	TR-595	CELLPRADCDMA	Cell Phone Radiation: CDMA	Rats	Hsd:Sprague Dawley SD	Female	Whole Body Exposure	Brain	Equivocal Evidence	Equivocal Evidence	glioma malignant (0/90, 3/90, 0/90, 0/90)	May Have Been Related
No	TR-595	CELLPRADCDMA	Cell Phone Radiation: CDMA	Rats	Hsd:Sprague Dawley SD	Male	Whole Body Exposure	Brain	Clear Evidence	Clear Evidence	glioma malignant (0/90, 0/90, 0/90, 3/90)	Neoplastic Lesions
No	TR-595	CELLPRADCDMA	Cell Phone Radiation: CDMA	Rats	Hsd:Sprague Dawley SD	Female	Whole Body Exposure	Heart	Equivocal Evidence	Equivocal Evidence	schwannoma malignant (0/90, 2/90, 0/90, 2/90)	May Have Been Related
Yes	TR-595	CELLPRADCDMA	Cell Phone Radiation: CDMA	Rats	Hsd:Sprague Dawley SD	Male	Whole Body Exposure	Heart	Clear Evidence	Clear Evidence	schwannoma malignant (0/90, 2/90, 3/90, 6/90)	Neoplastic Lesions
No	TR-595	CELLPRADCDMA	Cell Phone Radiation: CDMA	Rats	Hsd:Sprague Dawley SD	Male	Whole Body Exposure	Liver	Clear Evidence	Equivocal Evidence	hepatocellular adenoma or carcinoma (combined) (0/90, 2/90, 4/89, 1/88)	May Have Been Related
No	TR-595	CELLPRADCDMA	Cell Phone Radiation: CDMA	Rats	Hsd:Sprague Dawley SD	Male	Whole Body Exposure	Pituitary Gland	Clear Evidence	Equivocal Evidence	pars distalis, adenoma (17/89, 25/90, 34/90, 13/90)	May Have Been Related
No	TR-595	CELLPRADGSM	Cell Phone Radiation: GSM	Rats	Hsd:Sprague Dawley SD	Male	Whole Body Exposure	Adrenal Gland Medulla	Clear Evidence	Clear Evidence	benign, malignant, or complex pheochromocytoma (11/88, 24/90, 28/89, 14/87)	Neoplastic Lesions
No	TR-595	CELLPRADGSM	Cell Phone Radiation: GSM	Rats	Hsd:Sprague Dawley SD	Male	Whole Body Exposure	Brain	Clear Evidence	Equivocal Evidence	meninges, granular cell tumor benign or malignant (1/90, 3/90, 4/90, 3/90)	May Have Been Related
No	TR-595	CELLPRADGSM	Cell Phone Radiation: GSM	Rats	Hsd:Sprague Dawley SD	Male	Whole Body Exposure	Brain	Clear Evidence	Clear Evidence	glioma malignant (0/90, 3/90, 3/90, 2/90)	Neoplastic Lesions
No	TR-595	CELLPRADGSM	Cell Phone Radiation: GSM	Rats	Hsd:Sprague Dawley SD	Female	Whole Body Exposure	Heart	Equivocal Evidence	Equivocal Evidence	schwannoma malignant (0/90, 0/90, 2/90, 0/90)	May Have Been Related
Yes	TR-595	CELLPRADGSM	Cell Phone Radiation: GSM	Rats	Hsd:Sprague Dawley SD	Male	Whole Body Exposure	Heart	Clear Evidence	Clear Evidence	schwannoma malignant (0/90, 2/90, 1/90, 5/90)	Neoplastic Lesions
No	TR-595	CELLPRADGSM	Cell Phone Radiation: GSM	Rats	Hsd:Sprague Dawley SD	Male	Whole Body Exposure	Pancreas Islet Cell	Clear Evidence	Equivocal Evidence	adenoma or carcinoma (13/90, 27/89, 19/86, 16/85)	May Have Been Related
No	TR-595	CELLPRADGSM	Cell Phone Radiation: GSM	Rats	Hsd:Sprague Dawley SD	Male	Whole Body Exposure	Pituitary Gland	Clear Evidence	Equivocal Evidence	pars distalis, adenoma (17/89, 28/90, 26/90, 26/90)	May Have Been Related
No	TR-595	CELLPRADGSM	Cell Phone Radiation: GSM	Rats	Hsd:Sprague Dawley SD	Male	Whole Body Exposure	Prostate Gland	Clear Evidence	Equivocal Evidence	adenoma or carcinoma (2/90, 2/90, 7/90, 3/90)	May Have Been Related
No	TR-059	22966-79-6	Estradiol mustard	Rats	Sprague Dawley	Female	Gavage	Unspecified	Negative		Not applicable	Not applicable
No	TR-059	22966-79-6	Estradiol mustard	Rats	Sprague Dawley	Male	Gavage	Unspecified	Negative		Not applicable	Not applicable
No	TR-059	22966-79-6	Estradiol mustard	Mice	B6C3F1	Female	Gavage	Forestomach	Positive	Positive	(SQUAMOUS CELL CARCINOMA)	Neoplastic Lesions
No	TR-059	22966-79-6	Estradiol mustard	Mice	B6C3F1	Male	Gavage	Forestomach	Positive	Positive	(SQUAMOUS CELL CARCINOMA)	Neoplastic Lesions
Yes	TR-059	22966-79-6	Estradiol mustard	Mice	B6C3F1	Female	Gavage	Heart	Positive	Positive	(SARCOMA)	Neoplastic Lesions
Yes	TR-059	22966-79-6	Estradiol mustard	Mice	B6C3F1	Male	Gavage	Heart	Positive	Positive	(SARCOMA)	Neoplastic Lesions
No	TR-059	22966-79-6	Estradiol mustard	Mice	B6C3F1	Female	Gavage	Hematopoietic System	Positive	Positive	(LYMPHOMA)	Neoplastic Lesions
No	TR-059	22966-79-6	Estradiol mustard	Mice	B6C3F1	Male	Gavage	Hematopoietic System	Positive	Positive	(LYMPHOMA OR LEUKEMIA)	Neoplastic Lesions
No	TR-059	22966-79-6	Estradiol mustard	Mice	B6C3F1	Female	Gavage	Lung	Positive	Positive	(ALVEOLAR/BRONCHIOLAR ADENOMA OR CARCINOMA)	Neoplastic Lesions
No	TR-059	22966-79-6	Estradiol mustard	Mice	B6C3F1	Male	Gavage	Lung	Positive	Positive	(ALVEOLAR/BRONCHIOLAR ADENOMA, ALVEOLAR/BRONCHIOLAR CARCINOMA)	Neoplastic Lesions
No	TR-510	64-17-5	Ethanol	Mice	MV	Female	Dosed-Water	Unspecified	Inadequate Study		Not applicable	Not applicable
No	TR-510	64-17-5	Ethanol	Mice	MV	Male	Dosed-Water	Unspecified	Inadequate Study		Not applicable	Not applicable
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Male	Dosed-Water	All Organs	Clear Evidence	Equivocal Evidence	Mononuclear Cell Leukemia 21/48 26/48 27/48 27/47 31/48	May Have Been Related
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Female	Dosed-Water	All Organs	Clear Evidence	Clear Evidence	Mononuclear Cell Leukemia 14/48 11/48 21/48 19/48 27/48	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Female	Dosed-Water	Clitoral Gland	Clear Evidence	Clear Evidence	carcinoma 4/48 6/48 7/48 11/48 14/47	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Male	Dosed-Water	Epididymis	Clear Evidence	Clear Evidence	malignant mesothelioma 0/48 1/45 3/48 10/47 17/47	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Male	Dosed-Water	Epididymis or Testis	Clear Evidence	Clear Evidence	malignant mesothelioma 0/48 1/48 3/48 10/47 17/48	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Mice	MV	Female	Dosed-Water	Forestomach	Clear Evidence	Clear Evidence	squamous cell papilloma 1/45 1/45 1/47 5/45 9/44	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Mice	MV	Male	Dosed-Water	Forestomach	Clear Evidence	Clear Evidence	squamous cell papilloma 0/47 2/45 3/48 2/45 10/41 squamous cell carcinoma 0/47 0/45 0/48 0/45 2/41 squamous cell papilloma or carcinoma 0/47 2/45 3/48 2/45 12/41	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Female	Dosed-Water	Forestomach	Clear Evidence	Clear Evidence	squamous cell papilloma 0/48 1/48 0/48 0/47 3/46	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Mice	MV	Female	Dosed-Water	Harderian Gland	Clear Evidence	Clear Evidence	adenoma 2/45 19/47 20/47 24/46 40/46	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Mice	MV	Male	Dosed-Water	Harderian Gland	Clear Evidence	Clear Evidence	adenoma 3/47 17/47 23/47 32/46 42/47	Neoplastic Lesions
Yes	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Male	Dosed-Water	Heart	Clear Evidence	Clear Evidence	malignant schwannoma 2/48 3/48 3/48 7/47 8/48	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Mice	MV	Female	Dosed-Water	Lung	Clear Evidence	Clear Evidence	alveolar/bronchiolar adenoma 3/46 5/48 3/47 7/47 9/44	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Mice	MV	Male	Dosed-Water	Lung	Clear Evidence	Clear Evidence	alveolar/bronchiolar adenoma 0/47 7/46 7/47 13/47 17/47	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Mice	MV	Female	Dosed-Water	Mammary Gland	Clear Evidence	Clear Evidence	adenoacanthoma 0/45 0/48 0/47 1/47 8/45 adenocarcinoma 1/45 1/48 2/47 9/47 11/45 adenoacanthoma or adenocarcinoma 1/45 1/48 2/47 9/47 18/45	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Female	Dosed-Water	Mammary Gland	Clear Evidence	Clear Evidence	fibroadenoma 16/48 26/48 35/48 33/48 36/48	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Female	Dosed-Water	Oral Cavity	Clear Evidence	Clear Evidence	Tongue: squamous cell papilloma 0/48 1/48 0/48 1/48 0/48 squamous cell carcinoma 0/48 0/48 0/48 0/48 1/48	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Female	Dosed-Water	Oral Cavity	Clear Evidence	Clear Evidence	Oral mucosa: squamous cell papilloma 1/48 1/48 2/48 0/48 4/48 squamous cell carcinoma 0/48 0/48 0/48 1/48 2/48	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Female	Dosed-Water	Oral Cavity	Clear Evidence	Clear Evidence	Oral mucosa or tongue: squamous cell papilloma or carcinoma 1/48 2/48 2/48 2/48 7/48	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Male	Dosed-Water	Oral Cavity	Clear Evidence	Clear Evidence	Tongue: squamous cell papilloma 0/48 1/48 0/48 1/47 4/48	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Male	Dosed-Water	Oral Cavity	Clear Evidence	Clear Evidence	Oral mucosa or tongue: squamous cell papilloma or carcinoma 2/48 2/48 2/48 3/47 7/48	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Male	Dosed-Water	Oral Cavity	Clear Evidence	Clear Evidence	Oral mucosa: squamous cell papilloma 1/48 1/48 0/48 2/47 3/48 squamous cell carcinoma 1/48 0/48 1/48 1/47 0/48	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Mice	MV	Female	Dosed-Water	Ovary	Clear Evidence	Equivocal Evidence	granulosa cell tumor – benign or malignant 0/45 0/47 0/47 3/46 3/44	May Have Been Related
No	TR-588	5694-00-8	Glycidamide	Mice	MV	Female	Dosed-Water	Skin	Clear Evidence	Clear Evidence	fibrosarcoma 0/45 1/48 2/47 2/47 9/45 sarcoma 0/45 0/48 1/47 3/47 3/45 fibrosarcoma or sarcoma 0/45 1/48 3/47 5/47 12/45	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Mice	MV	Male	Dosed-Water	Skin	Clear Evidence	Clear Evidence	squamous cell papilloma 0/47 1/48 2/47 1/47 8/46 squamous cell carcinoma 0/47 0/48 0/47 0/47 2/46 squamous cell papilloma or carcinoma 0/47 1/48 2/47 1/47 9/46	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Male	Dosed-Water	Testis	Clear Evidence	Clear Evidence	malignant mesothelioma 0/48 1/47 3/48 6/47 13/48	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Female	Dosed-Water	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	adenoma 0/48 3/48 3/46 1/46 5/47 follicular cell carcinoma 0/48 0/48 2/46 3/46 3/47 follicular cell adenoma or carcinoma 0/48 3/48 5/46 4/46 8/47	Neoplastic Lesions
No	TR-588	5694-00-8	Glycidamide	Rats	F344 (NCTR)	Male	Dosed-Water	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	adenoma 2/47 1/42 3/48 3/47 8/46 follicular cell carcinoma 0/47 2/42 3/48 1/47 5/46 follicular cell adenoma or carcinoma 2/47 3/42 6/48 4/47 13/46	Neoplastic Lesions
No	TR-060	3546-10-9	Phenesterin	Rats	Sprague Dawley	Male	Gavage	Unspecified	Negative		Not applicable	Not applicable
Yes	TR-060	3546-10-9	Phenesterin	Mice	B6C3F1	Female	Gavage	Heart	Positive	Positive	(SARCOMA)	Neoplastic Lesions
Yes	TR-060	3546-10-9	Phenesterin	Mice	B6C3F1	Male	Gavage	Heart	Positive	Positive	(SARCOMA)	Neoplastic Lesions
No	TR-060	3546-10-9	Phenesterin	Mice	B6C3F1	Female	Gavage	Hematopoietic System	Positive	Positive	(LYMPHOMA)	Neoplastic Lesions
No	TR-060	3546-10-9	Phenesterin	Mice	B6C3F1	Male	Gavage	Hematopoietic System	Positive	Positive	(LYMPHOMA)	Neoplastic Lesions
No	TR-060	3546-10-9	Phenesterin	Mice	B6C3F1	Female	Gavage	Lung	Positive	Positive	(ALVEOLAR/BRONCHIOLAR CARCINOMA)	Neoplastic Lesions
No	TR-060	3546-10-9	Phenesterin	Mice	B6C3F1	Male	Gavage	Lung	Positive	Positive	(ALVEOLAR/BRONCHIOLAR CARCINOMA)	Neoplastic Lesions
No	TR-060	3546-10-9	Phenesterin	Rats	Sprague Dawley	Female	Gavage	Mammary Gland	Positive	Positive	(ADENOCARCINOMA)	Neoplastic Lesions
No	TR-510	51-79-6	Urethane	Mice	MV	Male	Dosed-Water	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA OR SQUAMOUS CELL CARCINOMA 0/46 2/47 3/44 5/45	Neoplastic Lesions
No	TR-510	51-79-6	Urethane	Mice	MV	Female	Dosed-Water	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 3/48 10/48 8/48 21/48 CARCINOMA 0/48 1/48 11/48 11/48 COMBINED 3/48 11/48 19/48 30/48	Neoplastic Lesions
No	TR-510	51-79-6	Urethane	Mice	MV	Male	Dosed-Water	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 3/47 11/47 25/47 28/47 CARCINOMA 0/47 1/47 7/47 16/47 COMBINED 3/47 12/47 30/47 38/47	Neoplastic Lesions
Yes	TR-510	51-79-6	Urethane	Mice	MV	Male	Dosed-Water	Heart	Clear Evidence	Clear Evidence	HEMANGIOSARCOMA 0/48 0/48 1/47 5/48	Neoplastic Lesions
No	TR-510	51-79-6	Urethane	Mice	MV	Female	Dosed-Water	Liver	Clear Evidence	Clear Evidence	HEMANGIOSARCOMA 0/48 0/47 1/47 7/47 ADENOMA 5/48 10/47 19/47 18/47 ADENOMA OR CARCINOMA 5/48 11/47 20/47 19/47	Neoplastic Lesions
No	TR-510	51-79-6	Urethane	Mice	MV	Male	Dosed-Water	Liver	Clear Evidence	Clear Evidence	HEMANGIOSARCOMA 1/46 2/47 5/46 13/44 ADENOMA 7/46 13/47 17/46 17/44 ADENOMA OR CARCINOMA 12/46 18/47 24/46 23/44	Neoplastic Lesions
No	TR-510	51-79-6	Urethane	Mice	MV	Female	Dosed-Water	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 4/48 6/48 17/48 29/47 ALVEOLAR/BRONCHIOLAR CARCINOMA 2/48 4/48 13/48 19/47 COMBINED 6/48 8/48 28/48 39/47	Neoplastic Lesions
No	TR-510	51-79-6	Urethane	Mice	MV	Male	Dosed-Water	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 4/48 17/48 22/47 34/48 ALVEOLAR/BRONCHIOLAR CARCINOMA 1/48 1/48 9/47 9/48 COMBINED 5/48 18/48 29/47 37/48	Neoplastic Lesions
No	TR-510	51-79-6	Urethane	Mice	MV	Female	Dosed-Water	Mammary Gland	Clear Evidence	Clear Evidence	ADENOACANTHOMA 0/47 1/46 1/46 11/48 ADENOCARCINOMA 4/47 3/46 3/46 11/48 COMBINED 4/47 4/46 4/46 22/48	Neoplastic Lesions
No	TR-510	51-79-6	Urethane	Mice	MV	Female	Dosed-Water	Ovary	Clear Evidence	Clear Evidence	BENIGN GRANULOSA CELL TUMOR 0/48 0/46 2/46 3/39 MALIGNANT GRANULOSA CELL TUMOR 0/48 0/46 0/46 3/39 COMBINED 0/48 0/46 2/46 5/39	Neoplastic Lesions
No	TR-510	51-79-6	Urethane	Mice	MV	Female	Dosed-Water	Skin	Clear Evidence	Clear Evidence	HEMANGIOSARCOMA 0/48 0/48 0/46 2/48	Neoplastic Lesions
No	TR-510	51-79-6	Urethane	Mice	MV	Male	Dosed-Water	Skin	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA OR SQUAMOUS CELL CARCINOMA (0/47, 1/48, 5/47, 8/48)	Neoplastic Lesions
No	TR-510	51-79-6	Urethane	Mice	MV	Female	Dosed-Water	Spleen	Clear Evidence	Clear Evidence	HEMANGIOSARCOMA 0/48 0/45 1/47 4/46	Neoplastic Lesions
No	TR-510	51-79-6	Urethane	Mice	MV	Female	Dosed-Water	Uterus/Cervix	Clear Evidence	Clear Evidence	HEMANGIOSARCOMA 0/48 0/47 0/48 2/46	Neoplastic Lesions
No	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Female	Dosed-Water	Harderian Gland	Clear Evidence	Clear Evidence	(URETHANE AND 5% ETHANOL) ADENOMA 4/48 7/48 6/46 20/46 CARCINOMA 1/48 11/48 7/46 10/46 COMBINED 5/48 18/48 13/46 29/46	Neoplastic Lesions
No	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Female	Dosed-Water	Harderian Gland	Clear Evidence	Clear Evidence	(URETHANE AND 2.5% ETHANOL) ADENOMA 2/47 3/47 9/46 19/47 CARCINOMA 1/47 3/47 6/46 16/47 COMBINED 3/47 5/47 15/46 35/47	Neoplastic Lesions
No	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Male	Dosed-Water	Harderian Gland	Clear Evidence	Clear Evidence	(URETHANE AND 2.5% ETHANOL) ADENOMA 6/48 14/48 21/47 27/48 CARCINOMA 0/48 0/48 1/47 16/48 COMBINED 6/48 14/48 21/47 38/48	Neoplastic Lesions
No	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Male	Dosed-Water	Harderian Gland	Clear Evidence	Clear Evidence	(URETHANE AND 5% ETHANOL) ADENOMA 5/47 12/48 15/48 26/45 CARCINOMA 0/47 2/48 2/48 10/45 COMBINED 5/47 14/48 17/48 35/45	Neoplastic Lesions
Yes	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Female	Dosed-Water	Heart	Clear Evidence	Clear Evidence	(URETHANE AND 5% ETHANOL) HEMANGIOSARCOMA 0/47 0/48 0/48 6/47	Neoplastic Lesions
Yes	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Female	Dosed-Water	Heart	Clear Evidence	Clear Evidence	(URETHANE AND 2.5% ETHANOL) HEMANGIOSARCOMA 0/47 0/47 0/48 3/48	Neoplastic Lesions
Yes	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Male	Dosed-Water	Heart	Clear Evidence	Clear Evidence	(URETHANE AND 2.5% ETHANOL) HEMANGIOSARCOMA 0/48 0/48 2/47 4/48	Neoplastic Lesions
Yes	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Male	Dosed-Water	Heart	Clear Evidence	Clear Evidence	(URETHANE AND 5% ETHANOL) HEMANGIOSARCOMA 0/47 0/48 1/48 4/48	Neoplastic Lesions
No	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Female	Dosed-Water	Liver	Clear Evidence	Clear Evidence	(URETHANE AND 5% ETHANOL) HEMANGIOSARCOMA 0/48 0/47 0/48 6/48 ADENOMA 3/48 6/47 16/48 16/48 ADENOMA OR CARCINOMA 3/48 7/47 16/48 17/48	Neoplastic Lesions
No	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Female	Dosed-Water	Liver	Clear Evidence	Clear Evidence	(URETHANE AND 2.5% ETHANOL) HEMANGIOSARCOMA 1/47 2/47 0/47 7/46 ADENOMA 6/47 5/47 15/47 23/46 ADENOMA OR CARCINOMA 7/47 5/47 16/47 23/46	Neoplastic Lesions
No	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Male	Dosed-Water	Liver	Clear Evidence	Clear Evidence	(URETHANE AND 5% ETHANOL) HEMANGIOSARCOMA 2/48 2/46 4/48 13/48	Neoplastic Lesions
No	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Male	Dosed-Water	Liver	Clear Evidence	Clear Evidence	(URETHANE AND 2.5% ETHANOL) HEMANGIOSARCOMA 3/47 4/48 3/46 11/48 ADENOMA 12/47 15/48 16/46 24/48 ADENOMA OR CARCINOMA 16/47 19/48 17/46 24/48	Neoplastic Lesions
No	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Female	Dosed-Water	Lung	Clear Evidence	Clear Evidence	(URETHANE AND 5% ETHANOL) ALVEOLAR/BRONCHIOLAR ADEMONA 5/48 10/48 18/48 30/48 ALVEOLAR/BRONCHIOLAR CARCINOMA 1/48 7/48 9/48 23/48 COMBINED 5/48 17/48 24/48 37/48	Neoplastic Lesions
No	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Female	Dosed-Water	Lung	Clear Evidence	Clear Evidence	(URETHANE AND 2.5% ETHANOL) ALVEOLAR/BRONCHIOLAR ADENOMA 5/47 10/47 16/48 28/48 ALVEOLAR/BRONCHIOLAR CARCINOMA 0/47 2/47 6/48 23/48 COMBINED 5/47 11/47 21/48 38/48	Neoplastic Lesions
No	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Male	Dosed-Water	Lung	Clear Evidence	Clear Evidence	(URETHANE AND 2.5% ETHANOL) ALVEOLAR/BRONCHIOLAR ADENOMA 10/48 16/48 19/47 35/48 ALVEOLAR/BRONCHIOLAR CARCINOMA 2/48 3/48 8/47 24/48 COMBINED 11/48 19/48 24/47 43/48	Neoplastic Lesions
No	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Male	Dosed-Water	Lung	Clear Evidence	Clear Evidence	(URETHANE AND 5% ETHANOL) ALVEOLAR/BRONCHIOLAR ADEMONA 6/48 8/48 9/48 33/48 ALVEOLAR/BRONCHIOLAR CARCINOMA 5/48 4/48 5/48 17/48 COMBINED 11/48 11/48 14/48 40/48	Neoplastic Lesions
No	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Female	Dosed-Water	Mammary Gland	Clear Evidence	Clear Evidence	(URETHANE AND 2.5% ETHANOL) ADENOACANTHOMA 0/47 0/45 2/48 3/47 ADENOCARCINOMA 4/47 3/45 11/48 14/47 COMBINED 4/47 3/45 12/48 16/47	Neoplastic Lesions
No	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Female	Dosed-Water	Mammary Gland	Clear Evidence	Clear Evidence	(URETHANE AND 5% ETHANOL) ADENOACANTHOMA 0/47 0/48 1/48 9/45 ADENOCARCINOMA 3/47 4/48 6/48 15/45 COMBINED 3/47 4/48 7/48 23/45	Neoplastic Lesions
No	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Female	Dosed-Water	Ovary	Clear Evidence	Clear Evidence	(URETHANE AND 5% ETHANOL) BENIGN GRANULOSA CELL TUMOR 0/46 0/47 5/46 3/45 BENIGN OR MALIGNANT GRANULOSA CELL TUMOR 0/46 0/47 6/46 3/45	Neoplastic Lesions
No	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Female	Dosed-Water	Skin	Clear Evidence	Clear Evidence	(URETHANE AND 2.5% ETHANOL) HEMANGIOSARCOMA 0/47 0/47 0/48 2/47	Neoplastic Lesions
No	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Male	Dosed-Water	Skin	Clear Evidence	Clear Evidence	(URETHANE AND 5% ETHANOL) SQUAMOUS CELL PAPILLOMA OR SQUAMOUS CELL CARCINOMA (0/48, 2/47, 0/48, 7/48)	Neoplastic Lesions
No	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Male	Dosed-Water	Skin	Clear Evidence	Clear Evidence	(URETHANE AND 2.5% ETHANOL) SQUAMOUS CELL PAPILLOMA OR SQUAMOUS CELL CARCINOMA (0/48, 1/48, 4/46, 7/47)	Neoplastic Lesions
No	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Female	Dosed-Water	Spleen	Clear Evidence	Clear Evidence	(URETHANE AND 2.5% ETHANOL) HEMANGIOSARCOMA 0/47 0/46 0/46 3/46	Neoplastic Lesions
No	TR-510	URETHCOMB	Urethane + ethanol (combination)	Mice	MV	Male	Dosed-Water	Spleen	Clear Evidence	Clear Evidence	(URETHANE AND 2.5% ETHANOL) HEMANGIOSARCOMA 0/46 0/46 1/46 3/46	Neoplastic Lesions