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The DNTP Technical Report (TR) Level of Evidence Criteria are available here: https://ntp.niehs.nih.gov/go/baresults. In the table below this information is further delineated into three fields:

  • Level of Evidence: The overall category of evidence of carcinogenic activity for the TR, Species, Strain and Sex
  • Organ Site Call: The level of evidence supported by the specific organ site for the TR, Species, Strain and Sex. When the Organ Site Call directly supports the TR Level Of Evidence the Finding Type flag is set to “Neoplastic Lesion”. Some Organ Site Calls could support a separate call of Equivocal Evidence; this is noted in Finding Type by the flag “May Have Been Related”
  • Finding Type: Further identification of the Organ Site Call. Where this says “Neoplastic Lesion” the Organ Site Call supports the TR Level of Evidence and the Organ Site Call is the same as that of the TR. Where Finding Type says “May Have Been Related” the TR Level of Evidence for other responses led to an overall call of Clear or Some Evidence but the specified organ supports a call of Equivocal Evidence.
View results
  • Organ: Heart
  • Level of Evidence: Positive, Clear Evidence, Some Evidence
Displays results that match exactly with the given criteria.
Exact Match Publication No. CASRN Test Article Name Species Strain Sex Route Organ Level of Evidence Organ Site Call Tumor Type/Incidence Finding Type
Yes TR-059 22966-79-6 Estradiol mustard Mice B6C3F1 Female Gavage Heart Positive Positive (SARCOMA) Neoplastic Lesions
Yes TR-059 22966-79-6 Estradiol mustard Mice B6C3F1 Male Gavage Heart Positive Positive (SARCOMA) Neoplastic Lesions
Yes TR-060 3546-10-9 Phenesterin Mice B6C3F1 Female Gavage Heart Positive Positive (SARCOMA) Neoplastic Lesions
Yes TR-060 3546-10-9 Phenesterin Mice B6C3F1 Male Gavage Heart Positive Positive (SARCOMA) Neoplastic Lesions
Yes TR-510 51-79-6 Urethane Mice MV Male Dosed-Water Heart Clear Evidence Clear Evidence HEMANGIOSARCOMA 0/48 0/48 1/47 5/48 Neoplastic Lesions
Yes TR-510 URETHCOMB Urethane + ethanol (combination) Mice MV Female Dosed-Water Heart Clear Evidence Clear Evidence (URETHANE AND 2.5% ETHANOL) HEMANGIOSARCOMA 0/47 0/47 0/48 3/48 Neoplastic Lesions
Yes TR-510 URETHCOMB Urethane + ethanol (combination) Mice MV Female Dosed-Water Heart Clear Evidence Clear Evidence (URETHANE AND 5% ETHANOL) HEMANGIOSARCOMA 0/47 0/48 0/48 6/47 Neoplastic Lesions
Yes TR-510 URETHCOMB Urethane + ethanol (combination) Mice MV Male Dosed-Water Heart Clear Evidence Clear Evidence (URETHANE AND 2.5% ETHANOL) HEMANGIOSARCOMA 0/48 0/48 2/47 4/48 Neoplastic Lesions
Yes TR-510 URETHCOMB Urethane + ethanol (combination) Mice MV Male Dosed-Water Heart Clear Evidence Clear Evidence (URETHANE AND 5% ETHANOL) HEMANGIOSARCOMA 0/47 0/48 1/48 4/48 Neoplastic Lesions
Yes TR-595 CELLPRADCDMA Cell Phone Radiation: CDMA Rats Hsd:Sprague Dawley SD Male Whole Body Exposure Heart Clear Evidence Clear Evidence schwannoma malignant (0/90, 2/90, 3/90, 6/90) Neoplastic Lesions
Yes TR-595 CELLPRADGSM Cell Phone Radiation: GSM Rats Hsd:Sprague Dawley SD Male Whole Body Exposure Heart Clear Evidence Clear Evidence schwannoma malignant (0/90, 2/90, 1/90, 5/90) Neoplastic Lesions
Yes TR-575 79-06-1 Acrylamide Rats F344 (NCTR) Male Dosed-Water Heart Clear Evidence Clear Evidence malignant Schwannoma 1/48 2/48 3/48 4/48 6/48 Neoplastic Lesions
Yes TR-588 5694-00-8 Glycidamide Rats F344 (NCTR) Male Dosed-Water Heart Clear Evidence Clear Evidence malignant schwannoma 2/48 3/48 3/48 7/47 8/48 Neoplastic Lesions
Yes TR-575 79-06-1 Acrylamide Rats F344 (NCTR) Female Dosed-Water Heart Clear Evidence Clear Evidence malignant Schwannoma 2/48 1/48 0/48 2/48 4/48 Neoplastic Lesions