COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:

Search Results

One moment please while the data are loaded...

The DNTP Technical Report (TR) Level of Evidence Criteria are available here: https://ntp.niehs.nih.gov/go/baresults. In the table below this information is further delineated into three fields:

  • Level of Evidence: The overall category of evidence of carcinogenic activity for the TR, Species, Strain and Sex
  • Organ Site Call: The level of evidence supported by the specific organ site for the TR, Species, Strain and Sex. When the Organ Site Call directly supports the TR Level Of Evidence the Finding Type flag is set to “Neoplastic Lesion”. Some Organ Site Calls could support a separate call of Equivocal Evidence; this is noted in Finding Type by the flag “May Have Been Related”
  • Finding Type: Further identification of the Organ Site Call. Where this says “Neoplastic Lesion” the Organ Site Call supports the TR Level of Evidence and the Organ Site Call is the same as that of the TR. Where Finding Type says “May Have Been Related” the TR Level of Evidence for other responses led to an overall call of Clear or Some Evidence but the specified organ supports a call of Equivocal Evidence.
View results
  • Organ: Hematopoietic System
  • Level of Evidence: Positive, Clear Evidence, Some Evidence
Displays results that match exactly with the given criteria.
Exact Match Publication No. CASRN Test Article Name Species Strain Sex Route Organ Level of Evidence Organ Site Call Tumor Type/Incidence Finding Type
Yes TR-019 366-70-1 Procarbazine hydrochloride Mice B6C3F1 Male Intraperitoneal Injection Hematopoietic System Positive Positive (LYMPHOMA OR LEUKEMIA) Neoplastic Lesions
Yes TR-019 366-70-1 Procarbazine hydrochloride Rats Sprague Dawley Female Intraperitoneal Injection Hematopoietic System Positive Positive (LYMPHOMA) Neoplastic Lesions
Yes TR-019 366-70-1 Procarbazine hydrochloride Rats Sprague Dawley Male Intraperitoneal Injection Hematopoietic System Positive Positive (LYMPHOMA OR LEUKEMIA) Neoplastic Lesions
Yes TR-032 3778-73-2 Isophosphamide Mice B6C3F1 Female Intraperitoneal Injection Hematopoietic System Positive Positive (LYMPHOMA) Neoplastic Lesions
Yes TR-019 366-70-1 Procarbazine hydrochloride Mice B6C3F1 Female Intraperitoneal Injection Hematopoietic System Positive Positive (LYMPHOMA OR LEUKEMIA) Neoplastic Lesions
Yes TR-053 121-66-4 2-Amino-5-nitrothiazole Rats F344/N Male Dosed-Feed Hematopoietic System Positive Positive (LYMPHOMA, LEUKEMIA) Neoplastic Lesions
Yes TR-058 52-24-4 tris(Aziridinyl)-phosphine sulfide (Thio-TEPA) Mice B6C3F1 Female Intraperitoneal Injection Hematopoietic System Positive Positive (LYMPHOMA, LEUKEMIA) Neoplastic Lesions
Yes TR-058 52-24-4 tris(Aziridinyl)-phosphine sulfide (Thio-TEPA) Mice B6C3F1 Male Intraperitoneal Injection Hematopoietic System Positive Positive (LYMPHOMA, LEUKEMIA) Neoplastic Lesions
Yes TR-058 52-24-4 tris(Aziridinyl)-phosphine sulfide (Thio-TEPA) Rats Sprague Dawley Male Intraperitoneal Injection Hematopoietic System Positive Positive (LYMPHOMA OR LEUKEMIA) Neoplastic Lesions
Yes TR-059 22966-79-6 Estradiol mustard Mice B6C3F1 Female Gavage Hematopoietic System Positive Positive (LYMPHOMA) Neoplastic Lesions
Yes TR-039 303-34-4 Lasiocarpine Rats F344/N Female Dosed-Feed Hematopoietic System Positive Positive Lymphoma/Leukemia Neoplastic Lesions
Yes TR-042 320-67-2 5-Azacytidine Mice B6C3F1 Female Intraperitoneal Injection Hematopoietic System Positive Positive (LYMPHOMA OR GRANULOCYTIC SARCOMA) Neoplastic Lesions
Yes TR-060 3546-10-9 Phenesterin Mice B6C3F1 Male Gavage Hematopoietic System Positive Positive (LYMPHOMA) Neoplastic Lesions
Yes TR-059 22966-79-6 Estradiol mustard Mice B6C3F1 Male Gavage Hematopoietic System Positive Positive (LYMPHOMA OR LEUKEMIA) Neoplastic Lesions
Yes TR-060 3546-10-9 Phenesterin Mice B6C3F1 Female Gavage Hematopoietic System Positive Positive (LYMPHOMA) Neoplastic Lesions
Yes TR-078 21416-87-5 ICRF-159 Mice B6C3F1 Female Intraperitoneal Injection Hematopoietic System Positive Positive (LYMPHOMA) Neoplastic Lesions
Yes TR-134 128-66-5 C.I. Vat Yellow 4 Mice B6C3F1 Male Dosed-Feed Hematopoietic System Positive Positive (LYMPHOMA) Neoplastic Lesions
Yes TR-128 91-93-0 3,3'-Dimethoxybenzidine-4,4'-diisocyanate Rats F344/N Female Dosed-Feed Hematopoietic System Positive Positive (LYMPHOMA OR LEUKEMIA) Neoplastic Lesions
Yes TR-128 91-93-0 3,3'-Dimethoxybenzidine-4,4'-diisocyanate Rats F344/N Male Dosed-Feed Hematopoietic System Positive Positive (LYMPHOMA OR LEUKEMIA) Neoplastic Lesions
Yes TR-144 117-79-3 2-Aminoanthraquinone Mice B6C3F1 Female Dosed-Feed Hematopoietic System Positive Positive (LYMPHOMA) Neoplastic Lesions
Yes TR-155 88-06-2 2,4,6-Trichlorophenol Rats F344/N Male Dosed-Feed Hematopoietic System Positive Positive (LEUKEMIA) Neoplastic Lesions
Yes TR-162 95-80-7 2,4-Diaminotoluene (2,4-toluene diamine) Mice B6C3F1 Female Dosed-Feed Hematopoietic System Positive Equivocal Evidence (LYMPHOMA) May Have Been Related
Yes TR-213 85-68-7 Butyl benzyl phthalate Rats F344/N Female Dosed-Feed Hematopoietic System Positive Positive LEUKEMIA 7/49 7/49 18/50 Neoplastic Lesions
Yes TR-222 2832-40-8 C.I. Disperse Yellow 3 Mice B6C3F1 Female Dosed-Feed Hematopoietic System Positive Equivocal Evidence LYMPHOMA 10/50 16/50 19/50 May Have Been Related
Yes TR-248 13552-44-8 4,4'-Methylenedianiline dihydrochloride Mice B6C3F1 Female Dosed-Water Hematopoietic System Positive Positive LYMPHOMA 13/50 28/50 29/50 Neoplastic Lesions
Yes TR-253 2835-39-4 Allyl isovalerate Mice B6C3F1 Female Gavage Hematopoietic System Positive Positive LYMPHOMA 11/50 11/50 18/50 Neoplastic Lesions
Yes TR-253 2835-39-4 Allyl isovalerate Rats F344/N Male Gavage Hematopoietic System Positive Positive LEUKEMIA 1/50 4/50 7/50 Neoplastic Lesions
Yes TR-285 569-61-9 C.I. Basic Red 9 Monohydrochloride Mice B6C3F1 Female Dosed-Feed Hematopoietic System Clear Evidence Equivocal Evidence LYMPHOMA 17/50 24/50 25/50 May Have Been Related
Yes TR-288 106-99-0 1,3-Butadiene Mice B6C3F1 Female Inhalation Hematopoietic System Clear Evidence Clear Evidence LYMPHOMA 1/50 10/49 10/49 Neoplastic Lesions
Yes TR-288 106-99-0 1,3-Butadiene Mice B6C3F1 Male Inhalation Hematopoietic System Clear Evidence Clear Evidence LYMPHOMA 0/50 23/50 29/50 Neoplastic Lesions
Yes TR-289 71-43-2 Benzene Mice B6C3F1 Female Gavage Hematopoietic System Clear Evidence Clear Evidence LYMPHOMA 15/49 25/45 26/50 22/49 Neoplastic Lesions
Yes TR-289 71-43-2 Benzene Mice B6C3F1 Male Gavage Hematopoietic System Clear Evidence Clear Evidence LYMPHOMA 4/49 10/48 10/50 15/49 Neoplastic Lesions
Yes TR-298 597-25-1 Dimethyl morpholinophosphoramidate Rats F344/N Female Gavage Hematopoietic System Some Evidence Some Evidence LEUKEMIA 9/50 13/50 12/49 18/50 Neoplastic Lesions
Yes TR-298 597-25-1 Dimethyl morpholinophosphoramidate Rats F344/N Male Gavage Hematopoietic System Some Evidence Some Evidence LEUKEMIA 14/50 21/50 19/50 25/50 Neoplastic Lesions
Yes TR-305 108171-27-3 Chlorinated paraffins: C23, 43% chlorine Mice B6C3F1 Male Gavage Hematopoietic System Clear Evidence Clear Evidence LYMPHOMA 6/50 12/50 16/50 Neoplastic Lesions
Yes TR-308 108171-26-2 Chlorinated paraffins: C12, 60% chlorine Rats F344/N Male Gavage Hematopoietic System Clear Evidence Equivocal Evidence LEUKEMIA 7/50 12/50 14/50 May Have Been Related
Yes TR-434 106-99-0 1,3-Butadiene Mice B6C3F1 Female Inhalation Hematopoietic System Clear Evidence Clear Evidence LYMPHOMA 6/50 12/50 11/50 7/50 9/50 32/80; HISTIOCYTIC SARCOMA 3/50 2/50 7/50 4/50 7/50 4/80 Neoplastic Lesions
Yes TR-434 106-99-0 1,3-Butadiene Mice B6C3F1 Male Inhalation Hematopoietic System Clear Evidence Clear Evidence LYMPHOMA 4/50 2/50 4/50 6/50 2/50 51/73, STOP STUDY 8/50 22/50 8/50 33/50; HISTIOCYTIC SARCOMA 0/50 0/50 4/50 5/50 7/50 4/73, STOP STUDY 5/50 2/50 7/50 2/50 Neoplastic Lesions
Yes TR-342 62-73-7 Dichlorvos Rats F344/N Male Gavage Hematopoietic System Some Evidence Some Evidence LEUKEMIA 11/50 20/50 21/50 Neoplastic Lesions
Yes TR-366 123-31-9 Hydroquinone Rats F344/N Female Gavage Hematopoietic System Some Evidence Some Evidence Leukemia 9/55 15/55 22/55 Neoplastic Lesions
Yes TR-311 127-18-4 Tetrachloroethylene Rats F344/N Female Inhalation Hematopoietic System Some Evidence Some Evidence LEUKEMIA 18/50 30/50 29/50 Neoplastic Lesions
Yes TR-311 127-18-4 Tetrachloroethylene Rats F344/N Male Inhalation Hematopoietic System Clear Evidence Clear Evidence LEUKEMIA 28/50 37/50 37/50 Neoplastic Lesions
Yes TR-332 149-30-4 2-Mercaptobenzothiazole Rats F344/N Male Gavage Hematopoietic System Some Evidence Some Evidence LEUKEMIA 7/50 16/50 3/50 Neoplastic Lesions
Yes TR-416 91-23-6 o-Nitroanisole Rats F344/N Female Dosed-Feed Hematopoietic System Clear Evidence Clear Evidence MONONUCLEAR CELL LEUKEMIA 14/50 11/50 14/50 26/50 Neoplastic Lesions
Yes TR-405 6459-94-5 C.I. Acid Red 114 Rats F344/N Female Dosed-Water Hematopoietic System Clear Evidence Equivocal Evidence MONONUCLEAR CELL LEUKEMIA 12/50 13/35 18/65 5/50 May Have Been Related
Yes TR-390 612-82-8 3,3'-Dimethylbenzidine dihydrochloride Rats F344/N Female Dosed-Water Hematopoietic System Clear Evidence Equivocal Evidence MONONUCLEAR CELL LEUKEMIA 1/60 3/45 6/75 4/60 May Have Been Related
Yes TR-416 91-23-6 o-Nitroanisole Rats F344/N Male Dosed-Feed Hematopoietic System Clear Evidence Clear Evidence MONONUCLEAR CELL LEUKEMIA 26/50 25/50 42/50 34/50 Neoplastic Lesions
Yes TR-397 2429-74-5 C.I. Direct Blue 15 Rats F344/N Female Dosed-Water Hematopoietic System Clear Evidence Clear Evidence MONONUCLEAR CELL LEUKEMIA 7/50 13/35 27/65 15/50 Neoplastic Lesions
Yes TR-374 556-52-5 Glycidol Rats F344/N Female Gavage Hematopoietic System Clear Evidence Clear Evidence LEUKEMIA 13/50 14/50 20/50 Neoplastic Lesions
Yes TR-323 756-79-6 Dimethyl methylphosphonate Rats F344/N Male Gavage Hematopoietic System Some Evidence Equivocal Evidence LEUKEMIA 10/50 11/50 17/50 May Have Been Related
Yes TR-402 110-00-9 Furan Rats F344/N Female Gavage Hematopoietic System Clear Evidence Clear Evidence MONONUCLEAR CELL LEUKEMIA 8/50 9/50 17/50 21/50 Neoplastic Lesions
Yes TR-397 2429-74-5 C.I. Direct Blue 15 Rats F344/N Male Dosed-Water Hematopoietic System Clear Evidence Equivocal Evidence MONONUCLEAR CELL LEUKEMIA 17/50 19/35 28/65 20/50 May Have Been Related
Yes TR-313 2385-85-5 Mirex Rats F344/N Female Dosed-Feed Hematopoietic System Clear Evidence Clear Evidence LEUKEMIA 6/52 9/52 14/52 Neoplastic Lesions
Yes TR-326 75-21-8 Ethylene oxide Mice B6C3F1 Female Inhalation Hematopoietic System Clear Evidence Clear Evidence LYMPHOMA 9/49 6/48 22/49 Neoplastic Lesions
Yes TR-340 5634-39-9 Iodinated glycerol Rats F344/N Male Gavage Hematopoietic System Some Evidence Some Evidence LEUKEMIA 14/50 29/50 24/50 Neoplastic Lesions
Yes TR-402 110-00-9 Furan Rats F344/N Male Gavage Hematopoietic System Clear Evidence Clear Evidence MONONUCLEAR CELL LEUKEMIA 8/50 11/50 17/50 25/50 Neoplastic Lesions
Yes TR-391 115-96-8 Tris(2-Chloroethyl) Phosphate Rats F344/N Female Gavage Hematopoietic System Clear Evidence Equivocal Evidence MONONUCLEAR CELL LEUKEMIA 14/50 16/50 20/50 May Have Been Related
Yes TR-391 115-96-8 Tris(2-Chloroethyl) Phosphate Rats F344/N Male Gavage Hematopoietic System Clear Evidence Equivocal Evidence MONONUCLEAR CELL LEUKEMIA 5/50 14/50 13/50 May Have Been Related
Yes TR-452 3296-90-0 2,2-bis(Bromomethyl)-1,3-propanediol Rats F344/N Male Dosed-Feed Hematopoietic System Clear Evidence Clear Evidence MONONUCLEAR CELL LEUKEMIA 27/51 29/53 40/51 34/55 25/60 Neoplastic Lesions
Yes TR-499 22398-80-7 Indium phosphide Rats F344/N Male Inhalation Hematopoietic System Clear Evidence Equivocal Evidence MONONUCLEAR CELL LEUKEMIA 16/50 23/50 29/50 25/50 May Have Been Related
Yes TR-504 88-72-2 o-Nitrotoluene Mice B6C3F1 Male Dosed-Feed Hematopoietic System Clear Evidence Clear Evidence HEMANGIOSARCOMA 4/60 17/60 55/60 60/60 Neoplastic Lesions
Yes TR-540 7220-79-3 Methylene blue trihydrate Mice B6C3F1 Male Gavage Hematopoietic System Some Evidence Equivocal Evidence MALIGNANT LYMPHOMA 2/50 2/50 2/50 5/50 May Have Been Related
Yes TR-450 116-14-3 Tetrafluoroethylene Mice B6C3F1 Female Inhalation Hematopoietic System Clear Evidence Clear Evidence HISTIOCYTIC SARCOMA 1/48 21/48 19/47 18/48 Neoplastic Lesions
Yes TR-450 116-14-3 Tetrafluoroethylene Mice B6C3F1 Male Inhalation Hematopoietic System Clear Evidence Clear Evidence HISTIOCYTIC SARCOMA 0/48 12/48 7/48 7/48 Neoplastic Lesions
Yes TR-450 116-14-3 Tetrafluoroethylene Rats F344/N Female Inhalation Hematopoietic System Clear Evidence Clear Evidence MONONUCLEAR CELL LEUKEMIA: 16/50 31/50 23/50 36/50 Neoplastic Lesions
Yes TR-537 631-64-1 Water disinfection byproducts (Dibromoacetic acid) Rats F344/N Female Dosed-Water Hematopoietic System Some Evidence Some Evidence MONONUCLEAR CELL LEUKEMIA (ALL ORGANS) 11/50 13/50 16/50 22/50 Neoplastic Lesions
Yes TR-537 631-64-1 Water disinfection byproducts (Dibromoacetic acid) Rats F344/N Male Dosed-Water Hematopoietic System Some Evidence Some Evidence MALIGNANT MESOTHELIOMA (ALL ORGANS) 3/50 1/50 0/50 10/50 Neoplastic Lesions
Yes TR-538 108-10-1 Methyl isobutyl ketone Rats F344/N Male Inhalation Hematopoietic System Some Evidence Equivocal Evidence MONONUCLEAR CELL LEUKEMIA 25/50 26/50 32/50 35/50 May Have Been Related
Yes TR-512 37319-17-8 Elmiron (sodium pentosanpolysulfate) Mice B6C3F1 Female Gavage Hematopoietic System Some Evidence Equivocal Evidence MALIGNANT LYMPHOMA (ALL ORGANS) 7/50 8/50 6/50 16/50 May Have Been Related
Yes TR-533 119-61-9 Benzophenone Mice B6C3F1/N Female Dosed-Feed Hematopoietic System Some Evidence Some Evidence HISTIOCYTIC SARCOMA: 0/50 0/50 5/50 3/50 Neoplastic Lesions
Yes TR-533 119-61-9 Benzophenone Rats F344/N Male Dosed-Feed Hematopoietic System Some Evidence Equivocal Evidence MONONUCLEAR CELL LEUKEMIA 27/50 41/50 39/50 24/50 May Have Been Related
Yes TR-450 116-14-3 Tetrafluoroethylene Rats F344/N Male Inhalation Hematopoietic System Clear Evidence Equivocal Evidence MONONUCLEAR CELL LEUKEMIA: 34/50 43/50 38/50 31/50 May Have Been Related
Yes TR-465 77-09-8 Phenolphthalein Mice B6C3F1 Female Dosed-Feed Hematopoietic System Clear Evidence Clear Evidence HISTIOCYTIC SARCOMA 0/50 2/50 7/50 7/50; LYMPHOMA 15/50 28/50 33/5 25/50; LYMPHOMA (THYMIC ORIGIN) 1/50 9/50 10/50 7/50 Neoplastic Lesions
Yes TR-465 77-09-8 Phenolphthalein Mice B6C3F1 Male Dosed-Feed Hematopoietic System Clear Evidence Clear Evidence HISTIOCYTIC SARCOMA 1/50 3/50 11/50 12/49; LYMPHOMA (THYMIC ORIGIN) 0/50 4/50 7/50 2/49 Neoplastic Lesions
Yes TR-492 1303-00-0 Gallium arsenide Rats F344/N Female Inhalation Hematopoietic System Clear Evidence Clear Evidence MONONUCLEAR CELL LEUKEMIA 22/50 21/50 18/50 33/50 Neoplastic Lesions
Yes TR-499 22398-80-7 Indium phosphide Rats F344/N Female Inhalation Hematopoietic System Clear Evidence Equivocal Evidence MONONUCLEAR CELL LEUKEMIA 14/50 21/50 14/50 24/50 May Have Been Related
Yes TR-508 23246-96-0 Riddelliine Rats F344/N Female Gavage Hematopoietic System Clear Evidence Clear Evidence MONONUCLEAR CELL LEUKEMIA (ALL ORGANS) 12/50 8/50 13/50 18/50 18/50 14/50 Neoplastic Lesions
Yes TR-508 23246-96-0 Riddelliine Rats F344/N Male Gavage Hematopoietic System Clear Evidence Clear Evidence Hematopoietic System: MONONUCLEAR CELL LEUKEMIA (ALL ORGANS) 2/50 9/50 Neoplastic Lesions
Yes TR-504 88-72-2 o-Nitrotoluene Mice B6C3F1 Female Dosed-Feed Hematopoietic System Clear Evidence Clear Evidence HEMANGIOSARCOMA 0/60 2/60 3/60 50/60 Neoplastic Lesions
Yes TR-543 98-83-9 alpha-Methylstyrene Rats F344/N Male Inhalation Hematopoietic System Some Evidence Equivocal Evidence MONONUCLEAR CELL LEUKEMIA 26/50 32/50 29/50 38/50 May Have Been Related