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The DNTP Technical Report (TR) Level of Evidence Criteria are available here: https://ntp.niehs.nih.gov/go/baresults. In the table below this information is further delineated into three fields:

Level of Evidence: The overall category of evidence of carcinogenic activity for the TR, Species, Strain and Sex
Organ Site Call: The level of evidence supported by the specific organ site for the TR, Species, Strain and Sex. When the Organ Site Call directly supports the TR Level Of Evidence the Finding Type flag is set to “Neoplastic Lesion”. Some Organ Site Calls could support a separate call of Equivocal Evidence; this is noted in Finding Type by the flag “May Have Been Related”
Finding Type: Further identification of the Organ Site Call. Where this says “Neoplastic Lesion” the Organ Site Call supports the TR Level of Evidence and the Organ Site Call is the same as that of the TR. Where Finding Type says “May Have Been Related” the TR Level of Evidence for other responses led to an overall call of Clear or Some Evidence but the specified organ supports a call of Equivocal Evidence.

Displays results that match exactly with the given criteria.
Exact Match	Publication No.	CASRN	Test Article Name	Species	Strain	Sex	Route	Organ	Level of Evidence	Organ Site Call	Tumor Type/Incidence	Finding Type
Yes	TR-019	366-70-1	Procarbazine hydrochloride	Mice	B6C3F1	Male	Intraperitoneal Injection	Hematopoietic System	Positive	Positive	(LYMPHOMA OR LEUKEMIA)	Neoplastic Lesions
Yes	TR-019	366-70-1	Procarbazine hydrochloride	Rats	Sprague Dawley	Female	Intraperitoneal Injection	Hematopoietic System	Positive	Positive	(LYMPHOMA)	Neoplastic Lesions
Yes	TR-019	366-70-1	Procarbazine hydrochloride	Rats	Sprague Dawley	Male	Intraperitoneal Injection	Hematopoietic System	Positive	Positive	(LYMPHOMA OR LEUKEMIA)	Neoplastic Lesions
Yes	TR-032	3778-73-2	Isophosphamide	Mice	B6C3F1	Female	Intraperitoneal Injection	Hematopoietic System	Positive	Positive	(LYMPHOMA)	Neoplastic Lesions
Yes	TR-019	366-70-1	Procarbazine hydrochloride	Mice	B6C3F1	Female	Intraperitoneal Injection	Hematopoietic System	Positive	Positive	(LYMPHOMA OR LEUKEMIA)	Neoplastic Lesions
Yes	TR-053	121-66-4	2-Amino-5-nitrothiazole	Rats	F344/N	Male	Dosed-Feed	Hematopoietic System	Positive	Positive	(LYMPHOMA, LEUKEMIA)	Neoplastic Lesions
Yes	TR-058	52-24-4	tris(Aziridinyl)-phosphine sulfide (Thio-TEPA)	Mice	B6C3F1	Female	Intraperitoneal Injection	Hematopoietic System	Positive	Positive	(LYMPHOMA, LEUKEMIA)	Neoplastic Lesions
Yes	TR-058	52-24-4	tris(Aziridinyl)-phosphine sulfide (Thio-TEPA)	Mice	B6C3F1	Male	Intraperitoneal Injection	Hematopoietic System	Positive	Positive	(LYMPHOMA, LEUKEMIA)	Neoplastic Lesions
Yes	TR-058	52-24-4	tris(Aziridinyl)-phosphine sulfide (Thio-TEPA)	Rats	Sprague Dawley	Male	Intraperitoneal Injection	Hematopoietic System	Positive	Positive	(LYMPHOMA OR LEUKEMIA)	Neoplastic Lesions
Yes	TR-059	22966-79-6	Estradiol mustard	Mice	B6C3F1	Female	Gavage	Hematopoietic System	Positive	Positive	(LYMPHOMA)	Neoplastic Lesions
Yes	TR-039	303-34-4	Lasiocarpine	Rats	F344/N	Female	Dosed-Feed	Hematopoietic System	Positive	Positive	Lymphoma/Leukemia	Neoplastic Lesions
Yes	TR-042	320-67-2	5-Azacytidine	Mice	B6C3F1	Female	Intraperitoneal Injection	Hematopoietic System	Positive	Positive	(LYMPHOMA OR GRANULOCYTIC SARCOMA)	Neoplastic Lesions
Yes	TR-060	3546-10-9	Phenesterin	Mice	B6C3F1	Male	Gavage	Hematopoietic System	Positive	Positive	(LYMPHOMA)	Neoplastic Lesions
Yes	TR-059	22966-79-6	Estradiol mustard	Mice	B6C3F1	Male	Gavage	Hematopoietic System	Positive	Positive	(LYMPHOMA OR LEUKEMIA)	Neoplastic Lesions
Yes	TR-060	3546-10-9	Phenesterin	Mice	B6C3F1	Female	Gavage	Hematopoietic System	Positive	Positive	(LYMPHOMA)	Neoplastic Lesions
Yes	TR-078	21416-87-5	ICRF-159	Mice	B6C3F1	Female	Intraperitoneal Injection	Hematopoietic System	Positive	Positive	(LYMPHOMA)	Neoplastic Lesions
Yes	TR-134	128-66-5	C.I. Vat Yellow 4	Mice	B6C3F1	Male	Dosed-Feed	Hematopoietic System	Positive	Positive	(LYMPHOMA)	Neoplastic Lesions
Yes	TR-128	91-93-0	3,3'-Dimethoxybenzidine-4,4'-diisocyanate	Rats	F344/N	Female	Dosed-Feed	Hematopoietic System	Positive	Positive	(LYMPHOMA OR LEUKEMIA)	Neoplastic Lesions
Yes	TR-128	91-93-0	3,3'-Dimethoxybenzidine-4,4'-diisocyanate	Rats	F344/N	Male	Dosed-Feed	Hematopoietic System	Positive	Positive	(LYMPHOMA OR LEUKEMIA)	Neoplastic Lesions
Yes	TR-144	117-79-3	2-Aminoanthraquinone	Mice	B6C3F1	Female	Dosed-Feed	Hematopoietic System	Positive	Positive	(LYMPHOMA)	Neoplastic Lesions
Yes	TR-155	88-06-2	2,4,6-Trichlorophenol	Rats	F344/N	Male	Dosed-Feed	Hematopoietic System	Positive	Positive	(LEUKEMIA)	Neoplastic Lesions
Yes	TR-162	95-80-7	2,4-Diaminotoluene (2,4-toluene diamine)	Mice	B6C3F1	Female	Dosed-Feed	Hematopoietic System	Positive	Equivocal Evidence	(LYMPHOMA)	May Have Been Related
Yes	TR-213	85-68-7	Butyl benzyl phthalate	Rats	F344/N	Female	Dosed-Feed	Hematopoietic System	Positive	Positive	LEUKEMIA 7/49 7/49 18/50	Neoplastic Lesions
Yes	TR-222	2832-40-8	C.I. Disperse Yellow 3	Mice	B6C3F1	Female	Dosed-Feed	Hematopoietic System	Positive	Equivocal Evidence	LYMPHOMA 10/50 16/50 19/50	May Have Been Related
Yes	TR-248	13552-44-8	4,4'-Methylenedianiline dihydrochloride	Mice	B6C3F1	Female	Dosed-Water	Hematopoietic System	Positive	Positive	LYMPHOMA 13/50 28/50 29/50	Neoplastic Lesions
Yes	TR-253	2835-39-4	Allyl isovalerate	Mice	B6C3F1	Female	Gavage	Hematopoietic System	Positive	Positive	LYMPHOMA 11/50 11/50 18/50	Neoplastic Lesions
Yes	TR-253	2835-39-4	Allyl isovalerate	Rats	F344/N	Male	Gavage	Hematopoietic System	Positive	Positive	LEUKEMIA 1/50 4/50 7/50	Neoplastic Lesions
Yes	TR-285	569-61-9	C.I. Basic Red 9 Monohydrochloride	Mice	B6C3F1	Female	Dosed-Feed	Hematopoietic System	Clear Evidence	Equivocal Evidence	LYMPHOMA 17/50 24/50 25/50	May Have Been Related
Yes	TR-288	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Hematopoietic System	Clear Evidence	Clear Evidence	LYMPHOMA 1/50 10/49 10/49	Neoplastic Lesions
Yes	TR-288	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Hematopoietic System	Clear Evidence	Clear Evidence	LYMPHOMA 0/50 23/50 29/50	Neoplastic Lesions
Yes	TR-289	71-43-2	Benzene	Mice	B6C3F1	Female	Gavage	Hematopoietic System	Clear Evidence	Clear Evidence	LYMPHOMA 15/49 25/45 26/50 22/49	Neoplastic Lesions
Yes	TR-289	71-43-2	Benzene	Mice	B6C3F1	Male	Gavage	Hematopoietic System	Clear Evidence	Clear Evidence	LYMPHOMA 4/49 10/48 10/50 15/49	Neoplastic Lesions
Yes	TR-298	597-25-1	Dimethyl morpholinophosphoramidate	Rats	F344/N	Female	Gavage	Hematopoietic System	Some Evidence	Some Evidence	LEUKEMIA 9/50 13/50 12/49 18/50	Neoplastic Lesions
Yes	TR-298	597-25-1	Dimethyl morpholinophosphoramidate	Rats	F344/N	Male	Gavage	Hematopoietic System	Some Evidence	Some Evidence	LEUKEMIA 14/50 21/50 19/50 25/50	Neoplastic Lesions
Yes	TR-305	108171-27-3	Chlorinated paraffins: C23, 43% chlorine	Mice	B6C3F1	Male	Gavage	Hematopoietic System	Clear Evidence	Clear Evidence	LYMPHOMA 6/50 12/50 16/50	Neoplastic Lesions
Yes	TR-308	108171-26-2	Chlorinated paraffins: C12, 60% chlorine	Rats	F344/N	Male	Gavage	Hematopoietic System	Clear Evidence	Equivocal Evidence	LEUKEMIA 7/50 12/50 14/50	May Have Been Related
Yes	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Hematopoietic System	Clear Evidence	Clear Evidence	LYMPHOMA 6/50 12/50 11/50 7/50 9/50 32/80; HISTIOCYTIC SARCOMA 3/50 2/50 7/50 4/50 7/50 4/80	Neoplastic Lesions
Yes	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Hematopoietic System	Clear Evidence	Clear Evidence	LYMPHOMA 4/50 2/50 4/50 6/50 2/50 51/73, STOP STUDY 8/50 22/50 8/50 33/50; HISTIOCYTIC SARCOMA 0/50 0/50 4/50 5/50 7/50 4/73, STOP STUDY 5/50 2/50 7/50 2/50	Neoplastic Lesions
Yes	TR-342	62-73-7	Dichlorvos	Rats	F344/N	Male	Gavage	Hematopoietic System	Some Evidence	Some Evidence	LEUKEMIA 11/50 20/50 21/50	Neoplastic Lesions
Yes	TR-366	123-31-9	Hydroquinone	Rats	F344/N	Female	Gavage	Hematopoietic System	Some Evidence	Some Evidence	Leukemia 9/55 15/55 22/55	Neoplastic Lesions
Yes	TR-311	127-18-4	Tetrachloroethylene	Rats	F344/N	Female	Inhalation	Hematopoietic System	Some Evidence	Some Evidence	LEUKEMIA 18/50 30/50 29/50	Neoplastic Lesions
Yes	TR-311	127-18-4	Tetrachloroethylene	Rats	F344/N	Male	Inhalation	Hematopoietic System	Clear Evidence	Clear Evidence	LEUKEMIA 28/50 37/50 37/50	Neoplastic Lesions
Yes	TR-332	149-30-4	2-Mercaptobenzothiazole	Rats	F344/N	Male	Gavage	Hematopoietic System	Some Evidence	Some Evidence	LEUKEMIA 7/50 16/50 3/50	Neoplastic Lesions
Yes	TR-416	91-23-6	o-Nitroanisole	Rats	F344/N	Female	Dosed-Feed	Hematopoietic System	Clear Evidence	Clear Evidence	MONONUCLEAR CELL LEUKEMIA 14/50 11/50 14/50 26/50	Neoplastic Lesions
Yes	TR-405	6459-94-5	C.I. Acid Red 114	Rats	F344/N	Female	Dosed-Water	Hematopoietic System	Clear Evidence	Equivocal Evidence	MONONUCLEAR CELL LEUKEMIA 12/50 13/35 18/65 5/50	May Have Been Related
Yes	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Hematopoietic System	Clear Evidence	Equivocal Evidence	MONONUCLEAR CELL LEUKEMIA 1/60 3/45 6/75 4/60	May Have Been Related
Yes	TR-416	91-23-6	o-Nitroanisole	Rats	F344/N	Male	Dosed-Feed	Hematopoietic System	Clear Evidence	Clear Evidence	MONONUCLEAR CELL LEUKEMIA 26/50 25/50 42/50 34/50	Neoplastic Lesions
Yes	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Female	Dosed-Water	Hematopoietic System	Clear Evidence	Clear Evidence	MONONUCLEAR CELL LEUKEMIA 7/50 13/35 27/65 15/50	Neoplastic Lesions
Yes	TR-374	556-52-5	Glycidol	Rats	F344/N	Female	Gavage	Hematopoietic System	Clear Evidence	Clear Evidence	LEUKEMIA 13/50 14/50 20/50	Neoplastic Lesions
Yes	TR-323	756-79-6	Dimethyl methylphosphonate	Rats	F344/N	Male	Gavage	Hematopoietic System	Some Evidence	Equivocal Evidence	LEUKEMIA 10/50 11/50 17/50	May Have Been Related
Yes	TR-402	110-00-9	Furan	Rats	F344/N	Female	Gavage	Hematopoietic System	Clear Evidence	Clear Evidence	MONONUCLEAR CELL LEUKEMIA 8/50 9/50 17/50 21/50	Neoplastic Lesions
Yes	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Male	Dosed-Water	Hematopoietic System	Clear Evidence	Equivocal Evidence	MONONUCLEAR CELL LEUKEMIA 17/50 19/35 28/65 20/50	May Have Been Related
Yes	TR-313	2385-85-5	Mirex	Rats	F344/N	Female	Dosed-Feed	Hematopoietic System	Clear Evidence	Clear Evidence	LEUKEMIA 6/52 9/52 14/52	Neoplastic Lesions
Yes	TR-326	75-21-8	Ethylene oxide	Mice	B6C3F1	Female	Inhalation	Hematopoietic System	Clear Evidence	Clear Evidence	LYMPHOMA 9/49 6/48 22/49	Neoplastic Lesions
Yes	TR-340	5634-39-9	Iodinated glycerol	Rats	F344/N	Male	Gavage	Hematopoietic System	Some Evidence	Some Evidence	LEUKEMIA 14/50 29/50 24/50	Neoplastic Lesions
Yes	TR-402	110-00-9	Furan	Rats	F344/N	Male	Gavage	Hematopoietic System	Clear Evidence	Clear Evidence	MONONUCLEAR CELL LEUKEMIA 8/50 11/50 17/50 25/50	Neoplastic Lesions
Yes	TR-391	115-96-8	Tris(2-Chloroethyl) Phosphate	Rats	F344/N	Female	Gavage	Hematopoietic System	Clear Evidence	Equivocal Evidence	MONONUCLEAR CELL LEUKEMIA 14/50 16/50 20/50	May Have Been Related
Yes	TR-391	115-96-8	Tris(2-Chloroethyl) Phosphate	Rats	F344/N	Male	Gavage	Hematopoietic System	Clear Evidence	Equivocal Evidence	MONONUCLEAR CELL LEUKEMIA 5/50 14/50 13/50	May Have Been Related
Yes	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Hematopoietic System	Clear Evidence	Clear Evidence	MONONUCLEAR CELL LEUKEMIA 27/51 29/53 40/51 34/55 25/60	Neoplastic Lesions
Yes	TR-499	22398-80-7	Indium phosphide	Rats	F344/N	Male	Inhalation	Hematopoietic System	Clear Evidence	Equivocal Evidence	MONONUCLEAR CELL LEUKEMIA 16/50 23/50 29/50 25/50	May Have Been Related
Yes	TR-504	88-72-2	o-Nitrotoluene	Mice	B6C3F1	Male	Dosed-Feed	Hematopoietic System	Clear Evidence	Clear Evidence	HEMANGIOSARCOMA 4/60 17/60 55/60 60/60	Neoplastic Lesions
Yes	TR-540	7220-79-3	Methylene blue trihydrate	Mice	B6C3F1	Male	Gavage	Hematopoietic System	Some Evidence	Equivocal Evidence	MALIGNANT LYMPHOMA 2/50 2/50 2/50 5/50	May Have Been Related
Yes	TR-450	116-14-3	Tetrafluoroethylene	Mice	B6C3F1	Female	Inhalation	Hematopoietic System	Clear Evidence	Clear Evidence	HISTIOCYTIC SARCOMA 1/48 21/48 19/47 18/48	Neoplastic Lesions
Yes	TR-450	116-14-3	Tetrafluoroethylene	Mice	B6C3F1	Male	Inhalation	Hematopoietic System	Clear Evidence	Clear Evidence	HISTIOCYTIC SARCOMA 0/48 12/48 7/48 7/48	Neoplastic Lesions
Yes	TR-450	116-14-3	Tetrafluoroethylene	Rats	F344/N	Female	Inhalation	Hematopoietic System	Clear Evidence	Clear Evidence	MONONUCLEAR CELL LEUKEMIA: 16/50 31/50 23/50 36/50	Neoplastic Lesions
Yes	TR-537	631-64-1	Water disinfection byproducts (Dibromoacetic acid)	Rats	F344/N	Female	Dosed-Water	Hematopoietic System	Some Evidence	Some Evidence	MONONUCLEAR CELL LEUKEMIA (ALL ORGANS) 11/50 13/50 16/50 22/50	Neoplastic Lesions
Yes	TR-537	631-64-1	Water disinfection byproducts (Dibromoacetic acid)	Rats	F344/N	Male	Dosed-Water	Hematopoietic System	Some Evidence	Some Evidence	MALIGNANT MESOTHELIOMA (ALL ORGANS) 3/50 1/50 0/50 10/50	Neoplastic Lesions
Yes	TR-538	108-10-1	Methyl isobutyl ketone	Rats	F344/N	Male	Inhalation	Hematopoietic System	Some Evidence	Equivocal Evidence	MONONUCLEAR CELL LEUKEMIA 25/50 26/50 32/50 35/50	May Have Been Related
Yes	TR-512	37319-17-8	Elmiron (sodium pentosanpolysulfate)	Mice	B6C3F1	Female	Gavage	Hematopoietic System	Some Evidence	Equivocal Evidence	MALIGNANT LYMPHOMA (ALL ORGANS) 7/50 8/50 6/50 16/50	May Have Been Related
Yes	TR-533	119-61-9	Benzophenone	Mice	B6C3F1/N	Female	Dosed-Feed	Hematopoietic System	Some Evidence	Some Evidence	HISTIOCYTIC SARCOMA: 0/50 0/50 5/50 3/50	Neoplastic Lesions
Yes	TR-533	119-61-9	Benzophenone	Rats	F344/N	Male	Dosed-Feed	Hematopoietic System	Some Evidence	Equivocal Evidence	MONONUCLEAR CELL LEUKEMIA 27/50 41/50 39/50 24/50	May Have Been Related
Yes	TR-450	116-14-3	Tetrafluoroethylene	Rats	F344/N	Male	Inhalation	Hematopoietic System	Clear Evidence	Equivocal Evidence	MONONUCLEAR CELL LEUKEMIA: 34/50 43/50 38/50 31/50	May Have Been Related
Yes	TR-465	77-09-8	Phenolphthalein	Mice	B6C3F1	Female	Dosed-Feed	Hematopoietic System	Clear Evidence	Clear Evidence	HISTIOCYTIC SARCOMA 0/50 2/50 7/50 7/50; LYMPHOMA 15/50 28/50 33/5 25/50; LYMPHOMA (THYMIC ORIGIN) 1/50 9/50 10/50 7/50	Neoplastic Lesions
Yes	TR-465	77-09-8	Phenolphthalein	Mice	B6C3F1	Male	Dosed-Feed	Hematopoietic System	Clear Evidence	Clear Evidence	HISTIOCYTIC SARCOMA 1/50 3/50 11/50 12/49; LYMPHOMA (THYMIC ORIGIN) 0/50 4/50 7/50 2/49	Neoplastic Lesions
Yes	TR-492	1303-00-0	Gallium arsenide	Rats	F344/N	Female	Inhalation	Hematopoietic System	Clear Evidence	Clear Evidence	MONONUCLEAR CELL LEUKEMIA 22/50 21/50 18/50 33/50	Neoplastic Lesions
Yes	TR-499	22398-80-7	Indium phosphide	Rats	F344/N	Female	Inhalation	Hematopoietic System	Clear Evidence	Equivocal Evidence	MONONUCLEAR CELL LEUKEMIA 14/50 21/50 14/50 24/50	May Have Been Related
Yes	TR-508	23246-96-0	Riddelliine	Rats	F344/N	Female	Gavage	Hematopoietic System	Clear Evidence	Clear Evidence	MONONUCLEAR CELL LEUKEMIA (ALL ORGANS) 12/50 8/50 13/50 18/50 18/50 14/50	Neoplastic Lesions
Yes	TR-508	23246-96-0	Riddelliine	Rats	F344/N	Male	Gavage	Hematopoietic System	Clear Evidence	Clear Evidence	Hematopoietic System: MONONUCLEAR CELL LEUKEMIA (ALL ORGANS) 2/50 9/50	Neoplastic Lesions
Yes	TR-504	88-72-2	o-Nitrotoluene	Mice	B6C3F1	Female	Dosed-Feed	Hematopoietic System	Clear Evidence	Clear Evidence	HEMANGIOSARCOMA 0/60 2/60 3/60 50/60	Neoplastic Lesions
Yes	TR-543	98-83-9	alpha-Methylstyrene	Rats	F344/N	Male	Inhalation	Hematopoietic System	Some Evidence	Equivocal Evidence	MONONUCLEAR CELL LEUKEMIA 26/50 32/50 29/50 38/50	May Have Been Related

Displays all results in TRs which have data that match the given criteria.
Exact Match	Publication No.	CASRN	Test Article Name	Species	Strain	Sex	Route	Organ	Level of Evidence	Organ Site Call	Tumor Type/Incidence	Finding Type
No	TR-288	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Brain	Clear Evidence	Equivocal Evidence	GLIOMA 0/50 2/48 1/49	May Have Been Related
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Brain	Clear Evidence	Clear Evidence	(STOP STUDY) GLIOMA 0/50 2/50 0/50 1/50	Neoplastic Lesions
No	TR-288	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Forestomach	Clear Evidence	Clear Evidence	PAPILLOMA 0/49 4/42 10/49	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA OR CARCINOMA 0/50 0/50 3/50 2/50 4/50 22/80	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA OR CARCINOMA 1/50 0/50 0/50 1/50 8/50 4/73, STOP STUDY 3/50 7/50 9/50 10/50	Neoplastic Lesions
No	TR-288	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Forestomach	Clear Evidence	Clear Evidence	PAPILLOMA 0/49 5/40 0/44	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA OR CARCINOMA 8/50 10/50 7/50 15/50 20/50 9/80	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA OR CARCINOMA 6/50 7/50 9/50 20/50 31/50 6/73, STOP STUDY 27/50 23/50 30/50 13/50	Neoplastic Lesions
Yes	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Hematopoietic System	Clear Evidence	Clear Evidence	LYMPHOMA 6/50 12/50 11/50 7/50 9/50 32/80; HISTIOCYTIC SARCOMA 3/50 2/50 7/50 4/50 7/50 4/80	Neoplastic Lesions
Yes	TR-288	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Hematopoietic System	Clear Evidence	Clear Evidence	LYMPHOMA 1/50 10/49 10/49	Neoplastic Lesions
Yes	TR-288	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Hematopoietic System	Clear Evidence	Clear Evidence	LYMPHOMA 0/50 23/50 29/50	Neoplastic Lesions
Yes	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Hematopoietic System	Clear Evidence	Clear Evidence	LYMPHOMA 4/50 2/50 4/50 6/50 2/50 51/73, STOP STUDY 8/50 22/50 8/50 33/50; HISTIOCYTIC SARCOMA 0/50 0/50 4/50 5/50 7/50 4/73, STOP STUDY 5/50 2/50 7/50 2/50	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Intestines (Small)	Clear Evidence	Equivocal Evidence	CARCINOMA 0/50 1/50 1/50 1/50 2/50 0/73	May Have Been Related
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Kidney Tubular Cell	Clear Evidence	Equivocal Evidence	ADENOMA 0/49 0/49 0/48 0/50 2/50 0/80	May Have Been Related
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 1/50 0/50 3/48 1/49 0/73, STOP STUDY 4/48 1/50 3/49 1/50	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Liver	Clear Evidence	Clear Evidence	ADENOMA OR CARCINOMA 15/49 14/49 15/50 19/50 16/50 2/80	Neoplastic Lesions
No	TR-288	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Liver	Clear Evidence	Clear Evidence	ADENOMA 0/50 1/47 4/49 OR CARCINOMA 0/50 1/47 1/49 COMBINED 0/50 2/47 5/49	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Liver	Clear Evidence	Clear Evidence	ADENOMA OR CARCINOMA 21/50 23/50 30/50 25/48 33/48 5/72, STOP STUDY 27/49 19/49 19/50 11/50	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA, ADENOCARCINOMA, OR CARCINOMA 4/50 15/50 19/50 24/50 25/50 22/78	Neoplastic Lesions
No	TR-288	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 3/49 9/48 20/49; ALVEOLAR/BRONCHIOLAR CARCINOMA 0/49 6/48 8/49	Neoplastic Lesions
No	TR-288	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 2/50 12/49 11/49; ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 2/49 5/49	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA, ADENOCARCINOMA, OR CARCINOMA 21/50 23/50 19/50 31/49 35/50 3/73, STOP STUDY 36/50 28/50 32/50 17/50	Neoplastic Lesions
No	TR-288	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Mammary Gland	Clear Evidence	Clear Evidence	ACINAR CELL CARCINOMA 0/50 2/49 6/49	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Mammary Gland	Clear Evidence	Clear Evidence	ADENOACANTHOMA, ADENOCARCINOMA, OR MALIGNANT MIXED TUMOR 0/50 2/50 4/50 12/50 15/50 16/80	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Ovary	Clear Evidence	Clear Evidence	BENIGN OR MALIGNANT GRANULOSA CELL TUMOR 1/49 0/49 1/48 9/50 8/50 6/79; ADENOMA OR BENIGN MIXED TUMOR 2/49 4/49 1/48 4/50 6/50 2/79	Neoplastic Lesions
No	TR-288	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Ovary	Clear Evidence	Clear Evidence	GRANULOSA CELL TUMOR 0/49 6/45 12/48	Neoplastic Lesions
No	TR-288	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Preputial Gland	Clear Evidence	Equivocal Evidence	SQUAMOUS CELL CARCINOMA 0/50 3/50 1/50	May Have Been Related
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Preputial Gland	Clear Evidence	Clear Evidence	CARCINOMA 0/50 0/50 0/50 0/50 5/50 0/73, STOP STUDY 1/50 4/50 4/50 3/50	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Subcutaneous Tissue	Clear Evidence	Equivocal Evidence	NEUROFIBROSARCOMA OR SARCOMA 1/50 2/50 3/50 5/50 3/50 3/80	May Have Been Related
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Vascular System (Heart)	Clear Evidence	Clear Evidence	HEMANGIOSARCOMA 0/50 0/50 0/50 1/49 21/50 23/80	Neoplastic Lesions
No	TR-288	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Vascular System (Heart)	Clear Evidence	Clear Evidence	HEMANGIOSARCOMA 0/50 11/48 18/49	Neoplastic Lesions
No	TR-288	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Vascular System (Heart)	Clear Evidence	Clear Evidence	HEMANGIOSARCOMA 0/50 16/49 7/49	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Vascular System (Heart)	Clear Evidence	Clear Evidence	HEMANGIOSARCOMA 0/50 0/49 1/50 5/48 20/48 4/73, STOP STUDY 15/50 7/50 33/50 13/50	Neoplastic Lesions
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Female	Inhalation	Zymbal Gland	Clear Evidence	Equivocal Evidence	ADENOMA OR CARCINOMA 0/50 0/50 0/50 0/50 0/50 2/80	May Have Been Related
No	TR-288	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Zymbal Gland	Clear Evidence	Equivocal Evidence	CARCINOMA 0/50 0/50 2/50	May Have Been Related
No	TR-434	106-99-0	1,3-Butadiene	Mice	B6C3F1	Male	Inhalation	Zymbal Gland	Clear Evidence	Equivocal Evidence	(STOP STUDY) CARCINOMA 1/50 0/50 2/50 2/50	May Have Been Related
No	TR-053	121-66-4	2-Amino-5-nitrothiazole	Mice	B6C3F1	Female	Dosed-Feed	Unspecified	Negative		Not applicable	Not applicable
No	TR-053	121-66-4	2-Amino-5-nitrothiazole	Mice	B6C3F1	Male	Dosed-Feed	Unspecified	Negative		Not applicable	Not applicable
No	TR-053	121-66-4	2-Amino-5-nitrothiazole	Rats	F344/N	Female	Dosed-Feed	Unspecified	Negative		Not applicable	Not applicable
Yes	TR-053	121-66-4	2-Amino-5-nitrothiazole	Rats	F344/N	Male	Dosed-Feed	Hematopoietic System	Positive	Positive	(LYMPHOMA, LEUKEMIA)	Neoplastic Lesions
No	TR-144	117-79-3	2-Aminoanthraquinone	Rats	F344/N	Female	Dosed-Feed	Unspecified	Inadequate Study		Not applicable	Not applicable
Yes	TR-144	117-79-3	2-Aminoanthraquinone	Mice	B6C3F1	Female	Dosed-Feed	Hematopoietic System	Positive	Positive	(LYMPHOMA)	Neoplastic Lesions
No	TR-144	117-79-3	2-Aminoanthraquinone	Mice	B6C3F1	Female	Dosed-Feed	Liver	Positive	Positive	(CARCINOMA)	Neoplastic Lesions
No	TR-144	117-79-3	2-Aminoanthraquinone	Mice	B6C3F1	Male	Dosed-Feed	Liver	Positive	Positive	(CARCINOMA)	Neoplastic Lesions
No	TR-144	117-79-3	2-Aminoanthraquinone	Rats	F344/N	Male	Dosed-Feed	Liver	Positive	Positive	(NEOPLASTIC NODULE OR CARCINOMA)	Neoplastic Lesions
No	TR-332	149-30-4	2-Mercaptobenzothiazole	Mice	B6C3F1	Male	Gavage	Unspecified	No Evidence		Not applicable	Not applicable
No	TR-332	149-30-4	2-Mercaptobenzothiazole	Rats	F344/N	Female	Gavage	Adrenal Gland Medulla	Some Evidence	Some Evidence	PHEOCHROMOCYTOMA 1/50 5/50 6/50	Neoplastic Lesions
No	TR-332	149-30-4	2-Mercaptobenzothiazole	Rats	F344/N	Male	Gavage	Adrenal Gland Medulla	Some Evidence	Some Evidence	PHEOCHROMOCYTOMA 18/50 25/50 22/49 OR MALIGNANT PHEOCHROMOCYTOMA 0/50 2/50 2/49 COMBINED 18/50 27/50 24/49	Neoplastic Lesions
Yes	TR-332	149-30-4	2-Mercaptobenzothiazole	Rats	F344/N	Male	Gavage	Hematopoietic System	Some Evidence	Some Evidence	LEUKEMIA 7/50 16/50 3/50	Neoplastic Lesions
No	TR-332	149-30-4	2-Mercaptobenzothiazole	Mice	B6C3F1	Female	Gavage	Liver	Equivocal Evidence	Equivocal Evidence	ADENOMA 3/50 7/49 4/50 OR CARCINOMA 1/50 5/49 0/50 COMBINED 4/50 12/49 4/50	Neoplastic Lesions
No	TR-332	149-30-4	2-Mercaptobenzothiazole	Rats	F344/N	Male	Gavage	Pancreas Acinar Cell	Some Evidence	Some Evidence	ADENOMA 2/50 13/50 6/50	Neoplastic Lesions
No	TR-332	149-30-4	2-Mercaptobenzothiazole	Rats	F344/N	Female	Gavage	Pituitary Gland	Some Evidence	Some Evidence	ADENOMA 15/49 24/50 25/50	Neoplastic Lesions
No	TR-332	149-30-4	2-Mercaptobenzothiazole	Rats	F344/N	Male	Gavage	Preputial Gland	Some Evidence	Some Evidence	ADENOMA 0/50 4/50 4/50 OR CARCINOMA 1/50 2/50 1/50 COMBINED 1/50 6/50 5/50	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Female	Dosed-Feed	Esophagus	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 0/51 1/53 10/52	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Esophagus	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/51 0/53 1/51 5/55 0/60	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Female	Dosed-Feed	Forestomach	Clear Evidence	Equivocal Evidence	SQUAMOUS CELL PAPILLOMA 0/52 1/50 5/51 3/50	May Have Been Related
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Male	Dosed-Feed	Forestomach	Clear Evidence	Equivocal Evidence	SQUAMOUS CELL PAPILLOMA 0/50 3/51 2/50 2/49 OR SQUAMOUS CELL CARCINOMA 0/50 0/51 1/50 2/49 COMBINED 0/50 3/51 3/50 4/49	May Have Been Related
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/51 0/53 0/51 1/55 5/60	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Female	Dosed-Feed	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 2/52 6/50 8/51 15/50 OR CARCINOMA 1/52 6/50 5/51 7/50 COMBINED 3/52 12/50 13/51 19/50	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Male	Dosed-Feed	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 3/50 6/51 12/50 18/49 OR CARCINOMA 1/50 1/51 4/50 4/49 COMBINED 4/50 7/51 16/50 22/49	Neoplastic Lesions
Yes	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Hematopoietic System	Clear Evidence	Clear Evidence	MONONUCLEAR CELL LEUKEMIA 27/51 29/53 40/51 34/55 25/60	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Intestines (Large)	Clear Evidence	Clear Evidence	ADENOMA OR CARCINOMA 0/51 0/53 3/51 4/55 11/59	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Intestines (Small)	Clear Evidence	Clear Evidence	ADENOMA OR CARCINOMA 0/51 0/53 0/51 2/53 5/59	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Kidney Tubular Cell	Clear Evidence	Equivocal Evidence	ADENOMA 0/51 0/53 1/51 3/55 1/59	May Have Been Related
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Male	Dosed-Feed	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 0/51 3/50 2/49	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Female	Dosed-Feed	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 3/52 3/50 9/51 17/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 2/52 2/50 6/51 5/50 COMBINED 5/52 5/50 15/51 19/50	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Male	Dosed-Feed	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 12/50 4/51 12/50 21/49 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 3/50 7/51 8/50 11/49 COMBINED 15/50 11/51 16/50 25/49	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 1/51 0/53 3/51 1/55 4/60 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/51 1/53 0/51 3/55 3/60 COMBINED 1/51 1/53 3/51 4/55 7/60	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Female	Dosed-Feed	Mammary Gland	Clear Evidence	Equivocal Evidence	CARCINOMA 0/52 0/50 1/51 2/50	May Have Been Related
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Female	Dosed-Feed	Mammary Gland	Clear Evidence	Clear Evidence	FIBROADENOMA 25/50 45/51 46/53 45/52	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Mammary Gland	Clear Evidence	Clear Evidence	FIBROADENOMA 0/51 4/53 6/51 6/55 5/60 OR ADENOMA 0/51 0/53 1/51 1/55 0/60 COMBINED 0/51 4/53 7/51 7/55 5/60	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Mesothelium (Abdominal Cavity/Tunica Vaginalis)	Clear Evidence	Clear Evidence	MESOTHELIOMA 0/51 3/53 8/51 9/55 26/60	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Female	Dosed-Feed	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 2/50 2/51 4/53 5/52 OR SQUAMOUS CELL CARCINOMA 0/50 1/51 1/53 1/52 COMBINED 2/50 3/51 5/53 6/52	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/51 4/53 8/51 10/55 12/60 OR SQUAMOUS CELL CARCINOMA 0/51 0/53 1/51 0/55 2/60 COMBINED 0/51 4/53 9/51 10/55 13/60	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Pancreas Acinar Cell	Clear Evidence	Equivocal Evidence	ADENOMA 1/51 2/53 4/51 3/53 3/59	May Have Been Related
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Seminal Vesicle	Clear Evidence	Clear Evidence	ADENOMA 0/51 0/53 0/51 0/55 1/59 OR CARCINOMA 0/51 0/53 0/51 0/55 1/59 COMBINED 0/51 0/53 0/51 0/55 2/59	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Skin	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 1/51 0/53 2/51 5/55 11/60 OR KERATOACANTHOMA 3/51 5/53 11/51 16/55 10/60 OR TRICHOEPITHELIOMA 0/51 0/53 0/51 1/55 1/60 OR BASAL CELL ADENOMA 0/51 1/53 0/51 3/55 6/60 OR BASAL CELL CARCINOMA 0/51 0/53 2/51 2/55 0/60 OR SQUAMOUS CELL CARCINOMA 0/51 0/53 0/51 0/55 1/60 COMBINED 4/51 6/53 14/51 24/55 21/60	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Female	Dosed-Feed	Subcutaneous Tissue	Clear Evidence	Clear Evidence	SARCOMA 0/52 1/50 4/51 11/50	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Subcutaneous Tissue	Clear Evidence	Clear Evidence	FIBROMA 2/51 8/53 11/51 15/55 7/60 OR FIBROSARCOMA 0/51 1/53 0/51 0/55 1/60 OR SARCOMA 0/51 0/53 2/51 3/55 2/60 COMBINED 2/51 9/53 13/51 16/55 10/60	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Female	Dosed-Feed	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 0/51 2/53 3/52 OR CARCINOMA 0/50 0/51 0/53 1/52 COMBINED 0/50 0/51 2/53 4/52	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/51 1/53 2/51 2/55 7/59 OR CARCINOMA 0/51 1/53 4/51 1/55 2/59 COMBINED 0/51 2/53 6/51 3/55 9/59	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Urinary Bladder	Clear Evidence	Clear Evidence	TRANSITIONAL CELL PAPILLOMA 0/51 0/53 1/51 2/55 1/59 OR TRANSITIONAL CELL CARCINOMA 0/51 0/53 0/51 1/55 1/59 COMBINED 0/51 0/53 1/51 3/55 2/59	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Female	Dosed-Feed	Vascular System (Unspecified)	Clear Evidence	Equivocal Evidence	HEMANGIOMA AND HEMANGIOSARCOMA 1/52 2/50 0/51 5/50	May Have Been Related
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Zymbal Gland	Clear Evidence	Clear Evidence	ADENOMA 0/51 0/53 1/51 3/55 2/60 OR CARCINOMA 2/51 1/53 3/51 2/55 15/60 COMBINED 2/51 1/53 4/51 5/55 15/60	Neoplastic Lesions
No	TR-162	95-80-7	2,4-Diaminotoluene (2,4-toluene diamine)	Mice	B6C3F1	Male	Dosed-Feed	Unspecified	Negative		Not applicable	Not applicable
Yes	TR-162	95-80-7	2,4-Diaminotoluene (2,4-toluene diamine)	Mice	B6C3F1	Female	Dosed-Feed	Hematopoietic System	Positive	Equivocal Evidence	(LYMPHOMA)	May Have Been Related
No	TR-162	95-80-7	2,4-Diaminotoluene (2,4-toluene diamine)	Mice	B6C3F1	Female	Dosed-Feed	Liver	Positive	Positive	(CARCINOMA)	Neoplastic Lesions
No	TR-162	95-80-7	2,4-Diaminotoluene (2,4-toluene diamine)	Rats	F344/N	Female	Dosed-Feed	Liver	Positive	Positive	(NEOPLASTIC NODULE, CARCINOMA)	Neoplastic Lesions
No	TR-162	95-80-7	2,4-Diaminotoluene (2,4-toluene diamine)	Rats	F344/N	Male	Dosed-Feed	Liver	Positive	Positive	(NEOPLASTIC NODULE, CARCINOMA)	Neoplastic Lesions
No	TR-162	95-80-7	2,4-Diaminotoluene (2,4-toluene diamine)	Rats	F344/N	Female	Dosed-Feed	Mammary Gland	Positive	Positive	(ADENOMA, CARCINOMA)	Neoplastic Lesions
No	TR-155	88-06-2	2,4,6-Trichlorophenol	Rats	F344/N	Female	Dosed-Feed	Unspecified	Negative		Not applicable	Not applicable
Yes	TR-155	88-06-2	2,4,6-Trichlorophenol	Rats	F344/N	Male	Dosed-Feed	Hematopoietic System	Positive	Positive	(LEUKEMIA)	Neoplastic Lesions
No	TR-155	88-06-2	2,4,6-Trichlorophenol	Mice	B6C3F1	Female	Dosed-Feed	Liver	Positive	Positive	(ADENOMA, CARCINOMA)	Neoplastic Lesions
No	TR-155	88-06-2	2,4,6-Trichlorophenol	Mice	B6C3F1	Male	Dosed-Feed	Liver	Positive	Positive	(ADENOMA, CARCINOMA)	Neoplastic Lesions
No	TR-128	91-93-0	3,3'-Dimethoxybenzidine-4,4'-diisocyanate	Mice	B6C3F1	Female	Dosed-Feed	Unspecified	Negative		Not applicable	Not applicable
No	TR-128	91-93-0	3,3'-Dimethoxybenzidine-4,4'-diisocyanate	Mice	B6C3F1	Male	Dosed-Feed	Unspecified	Negative		Not applicable	Not applicable
Yes	TR-128	91-93-0	3,3'-Dimethoxybenzidine-4,4'-diisocyanate	Rats	F344/N	Female	Dosed-Feed	Hematopoietic System	Positive	Positive	(LYMPHOMA OR LEUKEMIA)	Neoplastic Lesions
Yes	TR-128	91-93-0	3,3'-Dimethoxybenzidine-4,4'-diisocyanate	Rats	F344/N	Male	Dosed-Feed	Hematopoietic System	Positive	Positive	(LYMPHOMA OR LEUKEMIA)	Neoplastic Lesions
No	TR-128	91-93-0	3,3'-Dimethoxybenzidine-4,4'-diisocyanate	Rats	F344/N	Male	Dosed-Feed	Skin	Positive	Positive	(BASAL CELL ADENOMA, SQUAMOUS CELL CARCINOMA)	Neoplastic Lesions
No	TR-128	91-93-0	3,3'-Dimethoxybenzidine-4,4'-diisocyanate	Rats	F344/N	Female	Dosed-Feed	Uterus/Cervix	Positive	Positive	(POLYP)	Neoplastic Lesions
No	TR-128	91-93-0	3,3'-Dimethoxybenzidine-4,4'-diisocyanate	Rats	F344/N	Female	Dosed-Feed	Zymbal Gland	Positive	Positive	(CARCINOMA)	Neoplastic Lesions
No	TR-128	91-93-0	3,3'-Dimethoxybenzidine-4,4'-diisocyanate	Rats	F344/N	Male	Dosed-Feed	Zymbal Gland	Positive	Positive	(CARCINOMA)	Neoplastic Lesions
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Brain	Clear Evidence	Equivocal Evidence	ASTROCYTOMA 0/60 1/45 1/75 0/60; GLIOMA 0/60 0/45 1/75 1/60; MENINGIOMA 0/60 1/45 0/75 0/60	May Have Been Related
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Brain	Clear Evidence	Equivocal Evidence	GLIOMA 0/60 0/45 1/75 1/60; MENINGIOMA 0/60 0/45 0/75 1/60; MENINGEAL SARCOMA 0/60 0/45 1/75 0/60	May Have Been Related
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Clitoral Gland	Clear Evidence	Clear Evidence	ADENOMA 0/60 9/45 32/75 17/59 OR CARCINOMA 0/60 5/45 11/75 18/59 COMBINED 0/60 14/45 42/75 32/59	Neoplastic Lesions
Yes	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Hematopoietic System	Clear Evidence	Equivocal Evidence	MONONUCLEAR CELL LEUKEMIA 1/60 3/45 6/75 4/60	May Have Been Related
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Intestines (Large)	Clear Evidence	Clear Evidence	ADENOMATOUS POLYP 0/60 2/45 7/75 4/60 OR ADENOCARCINOMA 0/60 0/45 3/75 6/60 COMBINED 0/60 2/45 10/75 9/60	Neoplastic Lesions
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Intestines (Large)	Clear Evidence	Clear Evidence	ADENOMATOUS POLYP 0/60 0/45 7/75 10/60 OR ADENOCARCINOMA 0/60 0/45 3/75 15/60 COMBINED 0/60 0/45 10/75 23/75	Neoplastic Lesions
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Liver	Clear Evidence	Clear Evidence	NEOPLASTIC NODULE 0/60 0/45 7/74 3/60 OR CARCINOMA 0/60 0/45 1/74 1/60 COMBINED 0/60 0/45 7/74 4/60	Neoplastic Lesions
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Liver	Clear Evidence	Clear Evidence	NEOPLASTIC NODULE 0/60 0/45 29/75 26/60 OR CARCINOMA 0/60 0/45 12/75 12/60 COMBINED 0/60 0/45 35/75 33/60	Neoplastic Lesions
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 1/60 1/45 3/74 3/60 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/60 0/45 0/74 1/60 COMBINED 1/60 1/45 3/74 4/60	Neoplastic Lesions
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 1/60 0/45 7/75 6/60 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/60 0/45 1/75 0/60 COMBINED 1/60 0/45 8/75 6/60	Neoplastic Lesions
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Mammary Gland	Clear Evidence	Clear Evidence	ADENOCARCINOMA 0/60 1/45 3/75 6/60	Neoplastic Lesions
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Mesothelium (Abdominal Cavity/Tunica Vaginalis)	Clear Evidence	Clear Evidence	MESOTHELIOMA 0/60 0/45 3/75 4/60	Neoplastic Lesions
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/60 3/45 7/75 9/60 OR SQUAMOUS CELL CARCINOMA 0/60 1/45 2/75 4/60 COMBINED 0/60 3/45 9/75 13/60	Neoplastic Lesions
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/60 0/45 3/75 2/60 OR SQUAMOUS CELL CARCINOMA 0/60 0/45 1/75 3/60 COMBINED 0/60 0/45 4/75 5/60	Neoplastic Lesions
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Preputial Gland	Clear Evidence	Clear Evidence	ADENOMA 2/60 4/45 4/75 8/60 OR CARCINOMA 0/60 0/45 2/75 1/60 COMBINED 2/60 4/45 6/75 9/60	Neoplastic Lesions
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Skin	Clear Evidence	Clear Evidence	BASAL CELL ADENOMA 0/60 3/45 5/75 5/60 OR BASAL CELL CARCINOMA 0/60 0/45 5/75 4/60 COMBINED 0/60 3/45 10/75 9/60; SQUAMOUS CELL PAPILLOMA 0/60 1/45 6/75 5/60 OR SQUAMOUS CELL CARCINOMA 0/60 2/45 4/75 7/60 COMBINED 0/60 3/45 9/75 12/60	Neoplastic Lesions
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Skin	Clear Evidence	Clear Evidence	BASAL CELL ADENOMA 0/60 10/45 52/75 29/60 OR BASAL CELL CARCINOMA 0/60 1/45 4/75 2/60 COMBINED 0/60 11/45 54/75 30/60; SEBACEOUS GLAND ADENOMA 0/60 0/45 7/75 5/60; KERATOACANTHOMA 1/60 1/45 8/75 5/60; SQUAMOUS CELL PAPILLOMA 0/60 0/45 8/75 15/60 OR SQUAMOUS CELL CARCINOMA 0/60 2/45 10/75 13/60 COMBINED 0/60 2/45 17/75 27/60	Neoplastic Lesions
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Zymbal Gland	Clear Evidence	Clear Evidence	ADENOMA 0/60 4/45 11/75 12/60 OR CARCINOMA 0/60 2/45 22/75 35/60 COMBINED 0/57 6/45 32/75 42/60	Neoplastic Lesions
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Zymbal Gland	Clear Evidence	Clear Evidence	ADENOMA 1/60 1/45 13/75 16/60 OR CARCINOMA 0/60 2/45 21/75 23/60 COMBINED 1/60 3/45 32/75 36/60	Neoplastic Lesions
No	TR-248	13552-44-8	4,4'-Methylenedianiline dihydrochloride	Mice	B6C3F1	Male	Dosed-Water	Adrenal Gland Medulla	Positive	Positive	PHEOCHROMOCYTOMA 2/48 12/49 14/49	Neoplastic Lesions
Yes	TR-248	13552-44-8	4,4'-Methylenedianiline dihydrochloride	Mice	B6C3F1	Female	Dosed-Water	Hematopoietic System	Positive	Positive	LYMPHOMA 13/50 28/50 29/50	Neoplastic Lesions
No	TR-248	13552-44-8	4,4'-Methylenedianiline dihydrochloride	Mice	B6C3F1	Female	Dosed-Water	Liver	Positive	Positive	ADENOMA 3/50 9/50 12/50	Neoplastic Lesions
No	TR-248	13552-44-8	4,4'-Methylenedianiline dihydrochloride	Mice	B6C3F1	Male	Dosed-Water	Liver	Positive	Positive	CARCINOMA 10/49 33/50 29/50	Neoplastic Lesions
No	TR-248	13552-44-8	4,4'-Methylenedianiline dihydrochloride	Rats	F344/N	Male	Dosed-Water	Liver	Positive	Positive	NEOPLASTIC NODULE 1/50 12/50 25/50	Neoplastic Lesions
No	TR-248	13552-44-8	4,4'-Methylenedianiline dihydrochloride	Rats	F344/N	Female	Dosed-Water	Thyroid Gland C-Cell	Positive	Positive	ADENOMA 0/47 3/47 6/48	Neoplastic Lesions
No	TR-248	13552-44-8	4,4'-Methylenedianiline dihydrochloride	Mice	B6C3F1	Female	Dosed-Water	Thyroid Gland Follicular Cell	Positive	Positive	ADENOMA 0/50 1/47 13/50	Neoplastic Lesions
No	TR-248	13552-44-8	4,4'-Methylenedianiline dihydrochloride	Mice	B6C3F1	Male	Dosed-Water	Thyroid Gland Follicular Cell	Positive	Positive	ADENOMA 0/47 3/49 16/49	Neoplastic Lesions
No	TR-248	13552-44-8	4,4'-Methylenedianiline dihydrochloride	Rats	F344/N	Female	Dosed-Water	Thyroid Gland Follicular Cell	Positive	Positive	ADENOMA 0/47 2/47 17/48	Neoplastic Lesions
No	TR-248	13552-44-8	4,4'-Methylenedianiline dihydrochloride	Rats	F344/N	Male	Dosed-Water	Thyroid Gland Follicular Cell	Positive	Positive	CARCINOMA 0/49 0/47 7/48	Neoplastic Lesions
No	TR-042	320-67-2	5-Azacytidine	Mice	B6C3F1	Male	Intraperitoneal Injection	Unspecified	Inadequate Study		Not applicable	Not applicable
No	TR-042	320-67-2	5-Azacytidine	Rats	Sprague Dawley	Female	Intraperitoneal Injection	Unspecified	Inadequate Study		Not applicable	Not applicable
No	TR-042	320-67-2	5-Azacytidine	Rats	Sprague Dawley	Male	Intraperitoneal Injection	Unspecified	Inadequate Study		Not applicable	Not applicable
Yes	TR-042	320-67-2	5-Azacytidine	Mice	B6C3F1	Female	Intraperitoneal Injection	Hematopoietic System	Positive	Positive	(LYMPHOMA OR GRANULOCYTIC SARCOMA)	Neoplastic Lesions
No	TR-253	2835-39-4	Allyl isovalerate	Mice	B6C3F1	Male	Gavage	Unspecified	Negative		Not applicable	Not applicable
No	TR-253	2835-39-4	Allyl isovalerate	Rats	F344/N	Female	Gavage	Unspecified	Negative		Not applicable	Not applicable
Yes	TR-253	2835-39-4	Allyl isovalerate	Mice	B6C3F1	Female	Gavage	Hematopoietic System	Positive	Positive	LYMPHOMA 11/50 11/50 18/50	Neoplastic Lesions
Yes	TR-253	2835-39-4	Allyl isovalerate	Rats	F344/N	Male	Gavage	Hematopoietic System	Positive	Positive	LEUKEMIA 1/50 4/50 7/50	Neoplastic Lesions
Yes	TR-543	98-83-9	alpha-Methylstyrene	Rats	F344/N	Male	Inhalation	Hematopoietic System	Some Evidence	Equivocal Evidence	MONONUCLEAR CELL LEUKEMIA 26/50 32/50 29/50 38/50	May Have Been Related
No	TR-543	98-83-9	alpha-Methylstyrene	Rats	F344/N	Male	Inhalation	Kidney Tubular Cell	Some Evidence	Some Evidence	ADENOMA (STANDARD EVALUATION) 0/50 0/50 1/50 0/50 (STANDARD AND EXTENDED EVALUATIONS COMBINED) 1/50 2/50 2/50 5/50 ADENOMA OR CARCINOMA (STANDARD EVALUATION) 0/50 0/50 2/50 2/50 (STANDARD AND EXTENDED EVALUATIONS COMBINED) 1/50 2/50 3/50 7/50	Neoplastic Lesions
No	TR-543	98-83-9	alpha-Methylstyrene	Mice	B6C3F1/N	Male	Inhalation	Liver	Equivocal Evidence	Equivocal Evidence	ADENOMA OR CARCINOMA 28/50 36/50 33/50 37/50	May Have Been Related
No	TR-543	98-83-9	alpha-Methylstyrene	Mice	B6C3F1/N	Female	Inhalation	Liver	Clear Evidence	Clear Evidence	ADENOMA 10/50 20/50 21/50 23/50 CARCINOMA 3/50 9/50 6/50 18/50 ADENOMA OR CARCINOMA 13/50 26/50 24/50 33/50	Neoplastic Lesions
No	TR-289	71-43-2	Benzene	Mice	B6C3F1	Male	Gavage	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 0/49 9/46 13/49 11/48	Neoplastic Lesions
Yes	TR-289	71-43-2	Benzene	Mice	B6C3F1	Female	Gavage	Hematopoietic System	Clear Evidence	Clear Evidence	LYMPHOMA 15/49 25/45 26/50 22/49	Neoplastic Lesions
Yes	TR-289	71-43-2	Benzene	Mice	B6C3F1	Male	Gavage	Hematopoietic System	Clear Evidence	Clear Evidence	LYMPHOMA 4/49 10/48 10/50 15/49	Neoplastic Lesions
No	TR-289	71-43-2	Benzene	Mice	B6C3F1	Female	Gavage	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 4/49 2/42 5/50 9/49 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/49 3/42 6/50 6/49 COMBINED 4/49 5/42 10/50 13/49	Neoplastic Lesions
No	TR-289	71-43-2	Benzene	Mice	B6C3F1	Male	Gavage	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 6/49 6/48 8/50 12/49 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 5/49 11/48 12/50 14/49 COMBINED 10/49 16/48 19/50 21/49	Neoplastic Lesions
No	TR-289	71-43-2	Benzene	Mice	B6C3F1	Female	Gavage	Mammary Gland	Clear Evidence	Clear Evidence	CARCINOMA 0/49 2/45 5/50 10/49; CARCINOSARCOMA 0/49 0/45 1/50 4/49	Neoplastic Lesions
No	TR-289	71-43-2	Benzene	Rats	F344/N	Female	Gavage	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 1/50 4/50 8/50 5/50 OR SQUAMOUS CELL CARCINOMA 0/50 1/50 4/50 5/50 COMBINED 1/50 5/50 12/50 9/50	Neoplastic Lesions
No	TR-289	71-43-2	Benzene	Rats	F344/N	Male	Gavage	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 1/50 6/50 11/50 13/50 OR SQUAMOUS CELL CARCINOMA 0/50 3/50 5/50 7/50 COMBINED 1/50 9/50 16/50 19/50	Neoplastic Lesions
No	TR-289	71-43-2	Benzene	Mice	B6C3F1	Female	Gavage	Ovary	Clear Evidence	Clear Evidence	BENIGN MIXED TUMORS 0/47 1/44 12/49 7/48; GRANULOSA CELL TUMOR 1/47 1/44 6/49 7/48	Neoplastic Lesions
No	TR-289	71-43-2	Benzene	Mice	B6C3F1	Male	Gavage	Preputial Gland	Clear Evidence	Clear Evidence	SQUAMOUS CELL CARCINOMA 0/21 3/28 18/29 28/35	Neoplastic Lesions
No	TR-289	71-43-2	Benzene	Rats	F344/N	Male	Gavage	Skin	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 2/50 1/50 5/50; SQUAMOUS CELL CARCINOMA 0/50 5/50 3/50 8/50	Neoplastic Lesions
No	TR-289	71-43-2	Benzene	Mice	B6C3F1	Female	Gavage	Zymbal Gland	Clear Evidence	Clear Evidence	SQUAMOUS CELL CARCINOMA 0/43 0/32 1/37 3/31	Neoplastic Lesions
No	TR-289	71-43-2	Benzene	Mice	B6C3F1	Male	Gavage	Zymbal Gland	Clear Evidence	Clear Evidence	SQUAMOUS CELL CARCINOMA 0/43 1/34 4/40 21/39	Neoplastic Lesions
No	TR-289	71-43-2	Benzene	Rats	F344/N	Female	Gavage	Zymbal Gland	Clear Evidence	Clear Evidence	CARCINOMA 0/45 5/40 5/44 14/46	Neoplastic Lesions
No	TR-289	71-43-2	Benzene	Rats	F344/N	Male	Gavage	Zymbal Gland	Clear Evidence	Clear Evidence	CARCINOMA 2/32 6/46 10/42	Neoplastic Lesions
Yes	TR-533	119-61-9	Benzophenone	Rats	F344/N	Male	Dosed-Feed	Hematopoietic System	Some Evidence	Equivocal Evidence	MONONUCLEAR CELL LEUKEMIA 27/50 41/50 39/50 24/50	May Have Been Related
No	TR-533	119-61-9	Benzophenone	Rats	F344/N	Female	Dosed-Feed	Hematopoietic System	Equivocal Evidence	Equivocal Evidence	MONONUCLEAR CELL LEUKEMIA 19/50 25/50 30/50 29/50; HISTIOCYTIC SARCOMA 0/50 0/50 1/50 2/50	Neoplastic Lesions
Yes	TR-533	119-61-9	Benzophenone	Mice	B6C3F1/N	Female	Dosed-Feed	Hematopoietic System	Some Evidence	Some Evidence	HISTIOCYTIC SARCOMA: 0/50 0/50 5/50 3/50	Neoplastic Lesions
No	TR-533	119-61-9	Benzophenone	Rats	F344/N	Male	Dosed-Feed	Kidney Tubular Cell	Some Evidence	Some Evidence	ADENOMA (STANDARD EVALUATION) 1/50 1/50 2/50 4/50 (STANDARD AND EXTENDED EVALUATIONS COMBINED) 2/50 2/50 7/50 8/50	Neoplastic Lesions
No	TR-533	119-61-9	Benzophenone	Mice	B6C3F1/N	Female	Dosed-Feed	Liver	Some Evidence	Equivocal Evidence	ADENOMA 5/50 4/50 10/50 8/50	May Have Been Related
No	TR-533	119-61-9	Benzophenone	Mice	B6C3F1/N	Male	Dosed-Feed	Liver	Some Evidence	Some Evidence	ADENOMA 11/50 15/50 23/50 23/50 ADENOMA, CARCINOMA, OR HEPATOBLASTOMA 18/50 20/50 25/50 29/50	Neoplastic Lesions
No	TR-213	85-68-7	Butyl benzyl phthalate	Rats	F344/N	Male	Dosed-Feed	Unspecified	Inadequate Study		Not applicable	Not applicable
No	TR-213	85-68-7	Butyl benzyl phthalate	Mice	B6C3F1	Female	Dosed-Feed	Unspecified	Negative		Not applicable	Not applicable
No	TR-213	85-68-7	Butyl benzyl phthalate	Mice	B6C3F1	Male	Dosed-Feed	Unspecified	Negative		Not applicable	Not applicable
Yes	TR-213	85-68-7	Butyl benzyl phthalate	Rats	F344/N	Female	Dosed-Feed	Hematopoietic System	Positive	Positive	LEUKEMIA 7/49 7/49 18/50	Neoplastic Lesions
No	TR-405	6459-94-5	C.I. Acid Red 114	Rats	F344/N	Female	Dosed-Water	Adrenal Gland Medulla	Clear Evidence	Equivocal Evidence	PHEOCHROMOCYTOMA 1/50 3/35 5/64 1/50	May Have Been Related
No	TR-405	6459-94-5	C.I. Acid Red 114	Rats	F344/N	Male	Dosed-Water	Adrenal Gland Medulla	Clear Evidence	Equivocal Evidence	PHEOCHROMOCYTOMA 16/50 11/35 24/63 19/49 OR MALIGNANT PHEOCHROMOCYTOMA 2/50 0/35 3/63 2/49 COMBINED 17/50 11/35 27/63 21/49	May Have Been Related
No	TR-405	6459-94-5	C.I. Acid Red 114	Rats	F344/N	Female	Dosed-Water	Clitoral Gland	Clear Evidence	Clear Evidence	ADENOMA 7/48 10/32 10/62 10/50, CARCINOMA 4/48 9/32 19/62 15/50, COMBINED 11/48 17/32 28/62 23/50	Neoplastic Lesions
Yes	TR-405	6459-94-5	C.I. Acid Red 114	Rats	F344/N	Female	Dosed-Water	Hematopoietic System	Clear Evidence	Equivocal Evidence	MONONUCLEAR CELL LEUKEMIA 12/50 13/35 18/65 5/50	May Have Been Related
No	TR-405	6459-94-5	C.I. Acid Red 114	Rats	F344/N	Female	Dosed-Water	Intestines (Large)	Clear Evidence	Clear Evidence	NEOPLASMS 0/50 1/35 0/65 3/50	Neoplastic Lesions
No	TR-405	6459-94-5	C.I. Acid Red 114	Rats	F344/N	Female	Dosed-Water	Intestines (Small)	Clear Evidence	Clear Evidence	NEOPLASMS 0/50 0/35 1/65 2/50	Neoplastic Lesions
No	TR-405	6459-94-5	C.I. Acid Red 114	Rats	F344/N	Female	Dosed-Water	Liver	Clear Evidence	Clear Evidence	NEOPLASTIC NODULE 0/50 0/35 15/64 6/50, CARCINOMA 0/50 0/35 6/64 3/50, COMBINED 0/50 0/35 19/64 8/50	Neoplastic Lesions
No	TR-405	6459-94-5	C.I. Acid Red 114	Rats	F344/N	Male	Dosed-Water	Liver	Clear Evidence	Clear Evidence	NEOPLASTIC NODULE 2/50 1/35 10/65 15/50, CARCINOMA 0/50 1/35 6/65 7/50, COMBINED 2/50 2/35 15/65 20/50	Neoplastic Lesions
No	TR-405	6459-94-5	C.I. Acid Red 114	Rats	F344/N	Male	Dosed-Water	Lung	Clear Evidence	Equivocal Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 0/50 2/35 1/65 3/50, ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 0/35 1/65 0/50, COMBINED 2/50 2/35 2/65 3/50	May Have Been Related
No	TR-405	6459-94-5	C.I. Acid Red 114	Rats	F344/N	Female	Dosed-Water	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 1/50 2/35 8/65 4/50, ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 0/35 1/65 0/50, COMBINED 1/50 2/35 9/65 4/50	Neoplastic Lesions
No	TR-405	6459-94-5	C.I. Acid Red 114	Rats	F344/N	Female	Dosed-Water	Mammary Gland	Clear Evidence	Equivocal Evidence	ADENOCARCINOMA 0/50 3/35 6/65 3/50	May Have Been Related
No	TR-405	6459-94-5	C.I. Acid Red 114	Rats	F344/N	Male	Dosed-Water	Oral Cavity	Clear Evidence	Equivocal Evidence	SQUAMOUS CELL PAPILLOMA 0/50 0/35 1/65 2/50	May Have Been Related
No	TR-405	6459-94-5	C.I. Acid Red 114	Rats	F344/N	Female	Dosed-Water	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 3/35 6/65 4/50, SQUAMOUS CELL CARCINOMA 0/50 0/35 3/65 2/50, COMBINED 0/50 3/35 9/65 6/50	Neoplastic Lesions
No	TR-405	6459-94-5	C.I. Acid Red 114	Rats	F344/N	Female	Dosed-Water	Skin	Clear Evidence	Clear Evidence	BASAL CELL ADENOMA 0/50 3/35 5/65 3/50, BASAL CELL CARCINOMA 0/50 1/35 2/65 2/50, COMBINED 0/50 4/35 7/65 5/50	Neoplastic Lesions
No	TR-405	6459-94-5	C.I. Acid Red 114	Rats	F344/N	Male	Dosed-Water	Skin	Clear Evidence	Clear Evidence	BASAL CELL ADENOMA 1/50 4/35 26/65 30/50, BASAL CELL CARCINOMA 0/50 1/35 5/65 6/50, COMBINED 1/50 5/35 28/65 32/50; KERATOACANTHOMA 1/50 1/35 4/65 7/50; SEBACEOUS GLAND ADENOMA 0/50 1/35 5/65 5/50, SEBACEOUS GLAND CARCINOMA 1/50 0/35 0/65 1/50, COMBINED 1/50 1/35 5/65 6/50; SQUAMOUS CELL PAPILLOMA 1/50 0/35 3/65 2/50, SQUAMOUS CELL CARCINOMA 0/50 2/35 8/65 7/50, COMBINED 1/50 2/35 11/65 9/50	Neoplastic Lesions
No	TR-405	6459-94-5	C.I. Acid Red 114	Rats	F344/N	Female	Dosed-Water	Zymbal Gland	Clear Evidence	Clear Evidence	ADENOMA 0/50 0/35 2/65 6/50, CARCINOMA 0/50 3/35 17/65 13/50, COMBINED 0/50 3/35 18/65 19/50	Neoplastic Lesions
No	TR-405	6459-94-5	C.I. Acid Red 114	Rats	F344/N	Male	Dosed-Water	Zymbal Gland	Clear Evidence	Clear Evidence	ADENOMA 0/50 0/35 1/65 1/50, CARCINOMA 0/50 0/35 7/65 6/50, COMBINED 0/50 0/35 8/65 7/50	Neoplastic Lesions
No	TR-285	569-61-9	C.I. Basic Red 9 Monohydrochloride	Mice	B6C3F1	Female	Dosed-Feed	Adrenal Gland Medulla	Clear Evidence	Clear Evidence	PHEOCHROMOCYTOMA 1/48 7/47 7/45 OR MALIGNANT PHEOCHROMOCYTOMA 0/48 1/47 1/45 COMBINED 1/48 8/47 8/45	Neoplastic Lesions
Yes	TR-285	569-61-9	C.I. Basic Red 9 Monohydrochloride	Mice	B6C3F1	Female	Dosed-Feed	Hematopoietic System	Clear Evidence	Equivocal Evidence	LYMPHOMA 17/50 24/50 25/50	May Have Been Related
No	TR-285	569-61-9	C.I. Basic Red 9 Monohydrochloride	Mice	B6C3F1	Female	Dosed-Feed	Liver	Clear Evidence	Clear Evidence	CARCINOMA 3/49 19/50 37/49	Neoplastic Lesions
No	TR-285	569-61-9	C.I. Basic Red 9 Monohydrochloride	Mice	B6C3F1	Male	Dosed-Feed	Liver	Clear Evidence	Clear Evidence	CARCINOMA 10/50 20/50 27/50	Neoplastic Lesions
No	TR-285	569-61-9	C.I. Basic Red 9 Monohydrochloride	Rats	F344/N	Male	Dosed-Feed	Liver	Clear Evidence	Clear Evidence	CARCINOMA 0/50 2/50 8/50	Neoplastic Lesions
No	TR-285	569-61-9	C.I. Basic Red 9 Monohydrochloride	Rats	F344/N	Female	Dosed-Feed	Mammary Gland	Clear Evidence	Equivocal Evidence	ADENOMA 0/50 3/50 1/50, FIBROADENOMA 22/50 31/50 29/50, OR ADENOCARCINOMA 2/50 2/50 5/50 COMBINED 23/50 32/50 32/50	May Have Been Related
No	TR-285	569-61-9	C.I. Basic Red 9 Monohydrochloride	Rats	F344/N	Male	Dosed-Feed	Skin	Clear Evidence	Clear Evidence	TRICHOEPITHELIOMA 0/50 0/50 7/50; SEBACEOUS ADENOMA 0/50 0/50 5/50; SQUAMOUS CELL CARCINOMA 0/50 1/50 10/50	Neoplastic Lesions
No	TR-285	569-61-9	C.I. Basic Red 9 Monohydrochloride	Rats	F344/N	Female	Dosed-Feed	Subcutaneous Tissue	Clear Evidence	Clear Evidence	FIBROMA 0/50 15/50 10/50	Neoplastic Lesions
No	TR-285	569-61-9	C.I. Basic Red 9 Monohydrochloride	Rats	F344/N	Male	Dosed-Feed	Subcutaneous Tissue	Clear Evidence	Clear Evidence	FIBROMA 2/50 20/50 16/50	Neoplastic Lesions
No	TR-285	569-61-9	C.I. Basic Red 9 Monohydrochloride	Rats	F344/N	Female	Dosed-Feed	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/47 0/48 4/50 OR CARCINOMA 0/47 2/48 2/50 COMBINED 0/47 2/48 6/50	Neoplastic Lesions
No	TR-285	569-61-9	C.I. Basic Red 9 Monohydrochloride	Rats	F344/N	Male	Dosed-Feed	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/49 0/46 9/44 OR CARCINOMA 0/49 5/46 18/44	Neoplastic Lesions
No	TR-285	569-61-9	C.I. Basic Red 9 Monohydrochloride	Rats	F344/N	Female	Dosed-Feed	Zymbal Gland	Clear Evidence	Clear Evidence	CARCINOMA 0/50 2/50 7/50	Neoplastic Lesions
No	TR-285	569-61-9	C.I. Basic Red 9 Monohydrochloride	Rats	F344/N	Male	Dosed-Feed	Zymbal Gland	Clear Evidence	Clear Evidence	CARCINOMA 1/50 1/50 13/50	Neoplastic Lesions
No	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Male	Dosed-Water	Brain	Clear Evidence	Equivocal Evidence	ASTROCYTOMA 0/50 1/35 1/65 2/50	May Have Been Related
No	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Female	Dosed-Water	Clitoral Gland	Clear Evidence	Clear Evidence	ADENOMA 5/50 5/31 12/64 12/50, CARCINOMA 2/50 6/31 12/64 15/50, COMBINED 7/50 11/31 24/64 27/50	Neoplastic Lesions
Yes	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Male	Dosed-Water	Hematopoietic System	Clear Evidence	Equivocal Evidence	MONONUCLEAR CELL LEUKEMIA 17/50 19/35 28/65 20/50	May Have Been Related
Yes	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Female	Dosed-Water	Hematopoietic System	Clear Evidence	Clear Evidence	MONONUCLEAR CELL LEUKEMIA 7/50 13/35 27/65 15/50	Neoplastic Lesions
No	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Female	Dosed-Water	Intestines (Large)	Clear Evidence	Clear Evidence	ADENOMATOUS POLYP 0/50 0/35 3/65 1/50	Neoplastic Lesions
No	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Male	Dosed-Water	Intestines (Large)	Clear Evidence	Clear Evidence	NEOPLASMS 0/50 1/35 6/65 8/50	Neoplastic Lesions
No	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Female	Dosed-Water	Intestines (Small)	Clear Evidence	Clear Evidence	ADENOCARCINOMA 0/50 0/35 1/65 3/50	Neoplastic Lesions
No	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Male	Dosed-Water	Intestines (Small)	Clear Evidence	Clear Evidence	NEOPLASMS 0/50 1/35 0/65 2/50	Neoplastic Lesions
No	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Female	Dosed-Water	Liver	Clear Evidence	Clear Evidence	NEOPLASTIC NODULE 0/50 0/35 2/65 4/50, CARCINOMA 0/50 0/35 0/65 1/50, COMBINED 0/50 0/35 2/65 5/50	Neoplastic Lesions
No	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Male	Dosed-Water	Liver	Clear Evidence	Clear Evidence	NEOPLASTIC NODULE 0/50 6/35 8/65 7/50, CARCINOMA 0/50 0/35 1/65 4/50, COMBINED 0/50 6/35 9/65 11/50	Neoplastic Lesions
No	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Female	Dosed-Water	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 2/50 3/35 12/65 9/50, SQUAMOUS CELL CARCINOMA 0/50 1/35 8/65 6/50, COMBINED 2/50 4/35 19/65 15/50	Neoplastic Lesions
No	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Male	Dosed-Water	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 9/35 18/65 15/50, SQUAMOUS CELL CARCINOMA 1/50 1/35 6/65 2/50, COMBINED 1/50 10/35 24/65 17/50	Neoplastic Lesions
No	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Male	Dosed-Water	Preputial Gland	Clear Evidence	Clear Evidence	ADENOMA 6/49 2/35 12/64 8/48, CARCINOMA 2/49 3/35 11/64 1/48, COMBINED 8/49 5/35 23/64 9/48	Neoplastic Lesions
No	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Female	Dosed-Water	Skin	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 2/35 5/65 5/50, SQUAMOUS CELL CARCINOMA 0/50 0/35 1/65 0/50, COMBINED 0/50 2/35 6/65 5/50	Neoplastic Lesions
No	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Male	Dosed-Water	Skin	Clear Evidence	Clear Evidence	BASAL CELL ADENOMA 2/50 8/35 23/65 26/50, BASAL CELL CARCINOMA 0/50 2/35 4/65 10/50, COMBINED 2/50 9/35 27/65 28/50; SEBACEOUS GLAND ADENOMA 0/50 1/35 7/65 3/50; SQUAMOUS CELL PAPILLOMA 2/50 3/35 5/65 8/50, SQUAMOUS CELL CARCINOMA 0/50 1/35 7/65 13/50, COMBINED 2/50 4/35 11/65 19/50	Neoplastic Lesions
No	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Female	Dosed-Water	Uterus/Cervix	Clear Evidence	Clear Evidence	ADENOMA 0/50 0/35 1/65 1/50, ADENOCARCINOMA 1/50 0/35 0/65 3/50, COMBINED 1/50 0/35 1/65 4/50	Neoplastic Lesions
No	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Female	Dosed-Water	Zymbal Gland	Clear Evidence	Clear Evidence	ADENOMA 0/50 1/35 5/65 3/50, CARCINOMA 0/50 4/35 7/65 14/50, COMBINED 0/50 4/35 11/65 17/50	Neoplastic Lesions
No	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Male	Dosed-Water	Zymbal Gland	Clear Evidence	Clear Evidence	ADENOMA 0/50 2/35 2/65 4/50, CARCINOMA 1/50 3/35 8/65 17/50, COMBINED 1/50 5/35 10/65 20/50	Neoplastic Lesions
No	TR-222	2832-40-8	C.I. Disperse Yellow 3	Mice	B6C3F1	Male	Dosed-Feed	Unspecified	Negative		Not applicable	Not applicable
No	TR-222	2832-40-8	C.I. Disperse Yellow 3	Rats	F344/N	Female	Dosed-Feed	Unspecified	Negative		Not applicable	Not applicable
No	TR-222	2832-40-8	C.I. Disperse Yellow 3	Rats	F344/N	Male	Dosed-Feed	Forestomach	Positive	Equivocal Evidence	SQUAMOUS CELL PAPILLOMA 0/49 1/50 0/50; FIBROSARCOMA 0/49 1/50 0/50; SARCOMA 0/49 0/50 1/50	May Have Been Related
No	TR-222	2832-40-8	C.I. Disperse Yellow 3	Rats	F344/N	Male	Dosed-Feed	Glandular Stomach	Positive	Equivocal Evidence	ADENOMA 0/49 1/50 0/50; ADENOCARCINOMA 0/49 1/501/50; SARCOMA 0/49 0/50 1/50	May Have Been Related
Yes	TR-222	2832-40-8	C.I. Disperse Yellow 3	Mice	B6C3F1	Female	Dosed-Feed	Hematopoietic System	Positive	Equivocal Evidence	LYMPHOMA 10/50 16/50 19/50	May Have Been Related
No	TR-222	2832-40-8	C.I. Disperse Yellow 3	Mice	B6C3F1	Female	Dosed-Feed	Liver	Positive	Positive	ADENOMA 0/50 6/50 12/50	Neoplastic Lesions
No	TR-222	2832-40-8	C.I. Disperse Yellow 3	Rats	F344/N	Male	Dosed-Feed	Liver	Positive	Positive	NEOPLASTIC NODULE 1/49 15/50 10/50	Neoplastic Lesions
No	TR-134	128-66-5	C.I. Vat Yellow 4	Mice	B6C3F1	Female	Dosed-Feed	Unspecified	Negative		Not applicable	Not applicable
No	TR-134	128-66-5	C.I. Vat Yellow 4	Rats	F344/N	Female	Dosed-Feed	Unspecified	Negative		Not applicable	Not applicable
No	TR-134	128-66-5	C.I. Vat Yellow 4	Rats	F344/N	Male	Dosed-Feed	Unspecified	Negative		Not applicable	Not applicable
Yes	TR-134	128-66-5	C.I. Vat Yellow 4	Mice	B6C3F1	Male	Dosed-Feed	Hematopoietic System	Positive	Positive	(LYMPHOMA)	Neoplastic Lesions
Yes	TR-308	108171-26-2	Chlorinated paraffins: C12, 60% chlorine	Rats	F344/N	Male	Gavage	Hematopoietic System	Clear Evidence	Equivocal Evidence	LEUKEMIA 7/50 12/50 14/50	May Have Been Related
No	TR-308	108171-26-2	Chlorinated paraffins: C12, 60% chlorine	Rats	F344/N	Male	Gavage	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 7/50 3/49 ADENOCARCINOMA 0/50 2/50 0/49 COMBINED 0/50 9/50 3/49	Neoplastic Lesions
No	TR-308	108171-26-2	Chlorinated paraffins: C12, 60% chlorine	Mice	B6C3F1	Female	Gavage	Liver	Clear Evidence	Clear Evidence	ADENOMA 0/50 18/50 22/50 OR CARCINOMA 3/50 4/50 9/50 COMBINED 3/50 22/50 28/50	Neoplastic Lesions
No	TR-308	108171-26-2	Chlorinated paraffins: C12, 60% chlorine	Mice	B6C3F1	Male	Gavage	Liver	Clear Evidence	Clear Evidence	ADENOMA 11/50 20/50 29/50 OR CARCINOMA 11/50 15/50 17/50 COMBINED 2/50 34/50 38/50	Neoplastic Lesions
No	TR-308	108171-26-2	Chlorinated paraffins: C12, 60% chlorine	Rats	F344/N	Female	Gavage	Liver	Clear Evidence	Clear Evidence	NEOPLASTIC NODULE 0/50 4/50 7/50; CARCINOMA 0/50 1/50 1/50	Neoplastic Lesions
No	TR-308	108171-26-2	Chlorinated paraffins: C12, 60% chlorine	Rats	F344/N	Male	Gavage	Liver	Clear Evidence	Clear Evidence	NEOPLASTIC NODULE 0/50 10/50 16/48; CARCINOMA 0/50 3/50 2/48	Neoplastic Lesions
No	TR-308	108171-26-2	Chlorinated paraffins: C12, 60% chlorine	Mice	B6C3F1	Female	Gavage	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 8/50 12/49 18/49 OR CARCINOMA 0/50 0/49 2/49 COMBINED 8/50 12/49 15/49	Neoplastic Lesions
No	TR-308	108171-26-2	Chlorinated paraffins: C12, 60% chlorine	Rats	F344/N	Female	Gavage	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 6/50 3/50 OR CARCINOMA 0/50 0/50 3/50 COMBINED 0/50 6/50 6/50	Neoplastic Lesions
No	TR-305	108171-27-3	Chlorinated paraffins: C23, 43% chlorine	Rats	F344/N	Male	Gavage	Unspecified	No Evidence		Not applicable	Not applicable
No	TR-305	108171-27-3	Chlorinated paraffins: C23, 43% chlorine	Rats	F344/N	Female	Gavage	Adrenal Gland Medulla	Equivocal Evidence	Equivocal Evidence	PHEOCHROMOCYTOMA 1/50 4/50 6/50 7/50	Neoplastic Lesions
Yes	TR-305	108171-27-3	Chlorinated paraffins: C23, 43% chlorine	Mice	B6C3F1	Male	Gavage	Hematopoietic System	Clear Evidence	Clear Evidence	LYMPHOMA 6/50 12/50 16/50	Neoplastic Lesions
No	TR-305	108171-27-3	Chlorinated paraffins: C23, 43% chlorine	Mice	B6C3F1	Female	Gavage	Liver	Equivocal Evidence	Equivocal Evidence	ADENOMA 3/50 2/49 7/50 OR CARCINOMA 1/50 1/49 6/50 COMBINED 4/50 3/49 10/50	Neoplastic Lesions
No	TR-342	62-73-7	Dichlorvos	Mice	B6C3F1	Female	Gavage	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 5/49 6/49 18/50	Neoplastic Lesions
No	TR-342	62-73-7	Dichlorvos	Mice	B6C3F1	Male	Gavage	Forestomach	Some Evidence	Some Evidence	SQUAMOUS CELL PAPILLOMA 1/50 1/50 5/50	Neoplastic Lesions
Yes	TR-342	62-73-7	Dichlorvos	Rats	F344/N	Male	Gavage	Hematopoietic System	Some Evidence	Some Evidence	LEUKEMIA 11/50 20/50 21/50	Neoplastic Lesions
No	TR-342	62-73-7	Dichlorvos	Rats	F344/N	Female	Gavage	Mammary Gland	Equivocal Evidence	Equivocal Evidence	FIBROADENOMA 9/50 19/50 16/50 OR ADENOMA 0/50 0/50 1/50 COMBINED 9/50 19/50 17/50	Neoplastic Lesions
No	TR-342	62-73-7	Dichlorvos	Rats	F344/N	Female	Gavage	Pancreas Acinar Cell	Equivocal Evidence	Equivocal Evidence	ADENOMA 2/50 3/47 6/50	Neoplastic Lesions
No	TR-342	62-73-7	Dichlorvos	Rats	F344/N	Male	Gavage	Pancreas Acinar Cell	Some Evidence	Some Evidence	ADENOMA 25/50 30/49 33/50	Neoplastic Lesions
No	TR-323	756-79-6	Dimethyl methylphosphonate	Mice	B6C3F1	Male	Gavage	Unspecified	Inadequate Study		Not applicable	Not applicable
No	TR-323	756-79-6	Dimethyl methylphosphonate	Mice	B6C3F1	Female	Gavage	Unspecified	No Evidence		Not applicable	Not applicable
No	TR-323	756-79-6	Dimethyl methylphosphonate	Rats	F344/N	Female	Gavage	Unspecified	No Evidence		Not applicable	Not applicable
Yes	TR-323	756-79-6	Dimethyl methylphosphonate	Rats	F344/N	Male	Gavage	Hematopoietic System	Some Evidence	Equivocal Evidence	LEUKEMIA 10/50 11/50 17/50	May Have Been Related
No	TR-323	756-79-6	Dimethyl methylphosphonate	Rats	F344/N	Male	Gavage	Kidney Transitional Cell	Some Evidence	Some Evidence	PAPILLOMA 0/50 7/50 3/49	Neoplastic Lesions
No	TR-323	756-79-6	Dimethyl methylphosphonate	Rats	F344/N	Male	Gavage	Kidney Tubular Cell	Some Evidence	Some Evidence	ADENOCARCINOMA 0/50 2/50 3/49	Neoplastic Lesions
No	TR-298	597-25-1	Dimethyl morpholinophosphoramidate	Mice	B6C3F1	Female	Gavage	Unspecified	No Evidence		Not applicable	Not applicable
No	TR-298	597-25-1	Dimethyl morpholinophosphoramidate	Mice	B6C3F1	Male	Gavage	Unspecified	No Evidence		Not applicable	Not applicable
Yes	TR-298	597-25-1	Dimethyl morpholinophosphoramidate	Rats	F344/N	Female	Gavage	Hematopoietic System	Some Evidence	Some Evidence	LEUKEMIA 9/50 13/50 12/49 18/50	Neoplastic Lesions
Yes	TR-298	597-25-1	Dimethyl morpholinophosphoramidate	Rats	F344/N	Male	Gavage	Hematopoietic System	Some Evidence	Some Evidence	LEUKEMIA 14/50 21/50 19/50 25/50	Neoplastic Lesions
Yes	TR-512	37319-17-8	Elmiron (sodium pentosanpolysulfate)	Mice	B6C3F1	Female	Gavage	Hematopoietic System	Some Evidence	Equivocal Evidence	MALIGNANT LYMPHOMA (ALL ORGANS) 7/50 8/50 6/50 16/50	May Have Been Related
No	TR-512	37319-17-8	Elmiron (sodium pentosanpolysulfate)	Mice	B6C3F1	Male	Gavage	Liver	Some Evidence	Equivocal Evidence	ADENOMA OR CARCINOMA 23/50 23/50 26/50 31/50	May Have Been Related
No	TR-512	37319-17-8	Elmiron (sodium pentosanpolysulfate)	Mice	B6C3F1	Female	Gavage	Liver	Some Evidence	Some Evidence	HEMANGIOSARCOMA 1/50 1/49 1/50 4/49; ADENOMA 7/50 5/49 4/50 15/49; HEPATOCELLULAR ADENOMA OR CARCINOMA 10/50 8/49 9/50 18/49	Neoplastic Lesions
No	TR-512	37319-17-8	Elmiron (sodium pentosanpolysulfate)	Mice	B6C3F1	Male	Gavage	Liver	Some Evidence	Some Evidence	HEMANGIOSARCOMA 2/50 0/50 4/50 9/50	Neoplastic Lesions
No	TR-059	22966-79-6	Estradiol mustard	Rats	Sprague Dawley	Female	Gavage	Unspecified	Negative		Not applicable	Not applicable
No	TR-059	22966-79-6	Estradiol mustard	Rats	Sprague Dawley	Male	Gavage	Unspecified	Negative		Not applicable	Not applicable
No	TR-059	22966-79-6	Estradiol mustard	Mice	B6C3F1	Female	Gavage	Forestomach	Positive	Positive	(SQUAMOUS CELL CARCINOMA)	Neoplastic Lesions
No	TR-059	22966-79-6	Estradiol mustard	Mice	B6C3F1	Male	Gavage	Forestomach	Positive	Positive	(SQUAMOUS CELL CARCINOMA)	Neoplastic Lesions
No	TR-059	22966-79-6	Estradiol mustard	Mice	B6C3F1	Female	Gavage	Heart	Positive	Positive	(SARCOMA)	Neoplastic Lesions
No	TR-059	22966-79-6	Estradiol mustard	Mice	B6C3F1	Male	Gavage	Heart	Positive	Positive	(SARCOMA)	Neoplastic Lesions
Yes	TR-059	22966-79-6	Estradiol mustard	Mice	B6C3F1	Female	Gavage	Hematopoietic System	Positive	Positive	(LYMPHOMA)	Neoplastic Lesions
Yes	TR-059	22966-79-6	Estradiol mustard	Mice	B6C3F1	Male	Gavage	Hematopoietic System	Positive	Positive	(LYMPHOMA OR LEUKEMIA)	Neoplastic Lesions
No	TR-059	22966-79-6	Estradiol mustard	Mice	B6C3F1	Female	Gavage	Lung	Positive	Positive	(ALVEOLAR/BRONCHIOLAR ADENOMA OR CARCINOMA)	Neoplastic Lesions
No	TR-059	22966-79-6	Estradiol mustard	Mice	B6C3F1	Male	Gavage	Lung	Positive	Positive	(ALVEOLAR/BRONCHIOLAR ADENOMA, ALVEOLAR/BRONCHIOLAR CARCINOMA)	Neoplastic Lesions
No	TR-326	75-21-8	Ethylene oxide	Mice	B6C3F1	Female	Inhalation	Harderian Gland	Clear Evidence	Clear Evidence	CYSTADENOMA 1/46 6/46 8/47	Neoplastic Lesions
No	TR-326	75-21-8	Ethylene oxide	Mice	B6C3F1	Male	Inhalation	Harderian Gland	Clear Evidence	Clear Evidence	CYSTADENOMA 1/43 9/44 8/42	Neoplastic Lesions
Yes	TR-326	75-21-8	Ethylene oxide	Mice	B6C3F1	Female	Inhalation	Hematopoietic System	Clear Evidence	Clear Evidence	LYMPHOMA 9/49 6/48 22/49	Neoplastic Lesions
No	TR-326	75-21-8	Ethylene oxide	Mice	B6C3F1	Female	Inhalation	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 2/49 4/48 17/49; ALVEOLAR/BRONCHIOLAR CARCINOMA 0/49 1/48 7/49	Neoplastic Lesions
No	TR-326	75-21-8	Ethylene oxide	Mice	B6C3F1	Male	Inhalation	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 5/50 11/50 11/50; ALVEOLAR/BRONCHIOLAR CARCINOMA 6/50 10/50 16/50	Neoplastic Lesions
No	TR-326	75-21-8	Ethylene oxide	Mice	B6C3F1	Female	Inhalation	Mammary Gland	Clear Evidence	Clear Evidence	ADENOCARCINOMA 1/49 6/48 4/49; ADENOSQUAMOUS CARCINOMA 0/49 2/48 2/49	Neoplastic Lesions
No	TR-326	75-21-8	Ethylene oxide	Mice	B6C3F1	Female	Inhalation	Uterus/Cervix	Clear Evidence	Clear Evidence	ADENOCARCINOMA 0/49 1/47 5/49	Neoplastic Lesions
No	TR-402	110-00-9	Furan	Mice	B6C3F1	Female	Gavage	Adrenal Gland Medulla	Clear Evidence	Clear Evidence	PHEOCHROMOCYTOMA 2/50 1/50 6/50	Neoplastic Lesions
No	TR-402	110-00-9	Furan	Mice	B6C3F1	Male	Gavage	Adrenal Gland Medulla	Clear Evidence	Clear Evidence	PHEOCHROMOCYTOMA 1/49 6/50 10/50	Neoplastic Lesions
Yes	TR-402	110-00-9	Furan	Rats	F344/N	Female	Gavage	Hematopoietic System	Clear Evidence	Clear Evidence	MONONUCLEAR CELL LEUKEMIA 8/50 9/50 17/50 21/50	Neoplastic Lesions
Yes	TR-402	110-00-9	Furan	Rats	F344/N	Male	Gavage	Hematopoietic System	Clear Evidence	Clear Evidence	MONONUCLEAR CELL LEUKEMIA 8/50 11/50 17/50 25/50	Neoplastic Lesions
No	TR-402	110-00-9	Furan	Mice	B6C3F1	Female	Gavage	Liver	Clear Evidence	Clear Evidence	ADENOMA 5/50 31/50 48/50, CARCINOMA 2/50 7/50 27/50, COMBINED 7/50 34/50 50/50	Neoplastic Lesions
No	TR-402	110-00-9	Furan	Mice	B6C3F1	Male	Gavage	Liver	Clear Evidence	Clear Evidence	ADENOMA 20/50 33/50 42/50, CARCINOMA 7/50 32/50 34/50, COMBINED 26/50 44/50 50/50	Neoplastic Lesions
No	TR-402	110-00-9	Furan	Rats	F344/N	Female	Gavage	Liver	Clear Evidence	Clear Evidence	ADENOMA 0/50 2/50 4/50 7/50, CARCINOMA 0/50 0/50 0/50 1/50, COMBINED 0/50 2/50 4/50 8/50; CHOLANGIOCARCINOMA 0/50 49/50 50/50 48/50	Neoplastic Lesions
No	TR-402	110-00-9	Furan	Rats	F344/N	Male	Gavage	Liver	Clear Evidence	Clear Evidence	ADENOMA 1/50 4/50 18/50 27/50, CARCINOMA 0/50 1/50 6/50 18/50, COMBINED 1/50 5/50 22/50 35/50; CHOLANGIOCARCINOMA 0/50 43/50 48/50 49/50	Neoplastic Lesions
No	TR-492	1303-00-0	Gallium arsenide	Rats	F344/N	Female	Inhalation	Adrenal Gland Medulla	Clear Evidence	Clear Evidence	BENIGN PHEOCHROMOCYTOMA 4/50 5/49 6/50 13/49	Neoplastic Lesions
Yes	TR-492	1303-00-0	Gallium arsenide	Rats	F344/N	Female	Inhalation	Hematopoietic System	Clear Evidence	Clear Evidence	MONONUCLEAR CELL LEUKEMIA 22/50 21/50 18/50 33/50	Neoplastic Lesions
No	TR-492	1303-00-0	Gallium arsenide	Rats	F344/N	Female	Inhalation	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 0/50 0/50 2/50 7/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 0/50 2/50 3/50 COMBINED 0/50 0/50 4/50 9/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Female	Gavage	Brain	Clear Evidence	Clear Evidence	GLIOMA 0/50 4/50 4/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Male	Gavage	Brain	Clear Evidence	Clear Evidence	GLIOMA 0/50 5/50 6/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Female	Gavage	Clitoral Gland	Clear Evidence	Clear Evidence	ADENOMA 3/50 7/50 7/50, ADENOCARCINOMA 0/50 1/50 0/50, OR CARCINOMA 2/50 1/50 5/50 COMBINED 5/50 9/50 12/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Male	Gavage	Epididymis	Clear Evidence	Equivocal Evidence	SARCOMA 0/50 0/50 2/50	May Have Been Related
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Male	Gavage	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 2/50 9/50 OR SQUAMOUS CELL CARCINOMA 1/50 0/50 1/50 COMBINED 1/50 2/50 10/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Female	Gavage	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 4/50 8/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 3/50 COMBINED 0/50 4/50 11/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Male	Gavage	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 1/50 5/50 OR SQUAMOUS CELL CARCINOMA 1/50 1/50 2/50 COMBINED 1/50 2/50 6/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Female	Gavage	Glandular Stomach	Clear Evidence	Equivocal Evidence	FIBROSARCOMA 0/50 0/50 2/50	May Have Been Related
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Female	Gavage	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 4/50 10/50 16/50 OR ADENOCARCINOMA 0/50 1/50 1/50 COMBINED 4/50 11/50 17/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Male	Gavage	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 7/50 10/50 16/50 OR ADENOCARCINOMA 1/50 2/50 7/50 COMBINED 8/50 12/50 22/50	Neoplastic Lesions
Yes	TR-374	556-52-5	Glycidol	Rats	F344/N	Female	Gavage	Hematopoietic System	Clear Evidence	Clear Evidence	LEUKEMIA 13/50 14/50 20/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Male	Gavage	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMATOUS POLYP 0/50 0/50 1/50 OR ADENOCARCINOMA 0/50 1/50 3/50 COMBINED 0/50 1/50 4/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Male	Gavage	Liver	Clear Evidence	Clear Evidence	ADENOMA 18/50 16/50 30/50 OR CARCINOMA 10/50 17/50 8/50 COMBINED 24/50 31/50 35/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Male	Gavage	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 6/50 6/50 8/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 7/50 5/50 14/50 COMBINED 13/50 11/50 21/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Female	Gavage	Mammary Gland	Clear Evidence	Clear Evidence	ADENOMA 0/50 1/50 0/50, FIBROADENOMA 1/50 0/50 0/50, OR ADENOCARCINOMA 1/50 5/50 15/50 COMBINED 2/50 6/50 15/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Female	Gavage	Mammary Gland	Clear Evidence	Clear Evidence	FIBROADENOMA 14/50 32/50 29/50; ADENOCARCINOMA 1/50 11/50 16/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Male	Gavage	Mammary Gland	Clear Evidence	Clear Evidence	FIBROADENOMA 3/50 8/50 7/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Male	Gavage	Mesothelium (Abdominal Cavity/Tunica Vaginalis)	Clear Evidence	Clear Evidence	MESOTHELIOMA 3/50 34/50 39/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Female	Gavage	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 1/50 3/50 6/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 1/50 COMBINED 1/50 3/50 7/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Female	Gavage	Skin	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 0/50 1/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 1/50 COMBINED 0/50 0/50 2/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Male	Gavage	Skin	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 0/50 4/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Male	Gavage	Skin	Clear Evidence	Clear Evidence	SEBACEOUS GLAND ADENOMA 0/50 0/50 1/50, BASAL CELL CARCINOMA 0/50 4/50 2/50, OR SEBACEOUS GLAND ADENOCARCINOMA 0/50 0/50 1/50 COMBINED 0/50 5/50 4/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Female	Gavage	Subcutaneous Tissue	Clear Evidence	Clear Evidence	SARCOMA 0/50 1/50 6/50 OR FIBROSARCOMA 0/50 2/50 3/50 COMBINED 0/50 3/50 9/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Female	Gavage	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 1/50 0/49 OR CARCINOMA 0/50 0/50 3/49 COMBINED 0/50 1/50 3/49	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Male	Gavage	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 2/50 2/50 OR CARCINOMA 1/50 2/50 5/50 COMBINED 1/50 4/50 6/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Male	Gavage	Urinary Bladder	Clear Evidence	Equivocal Evidence	CARCINOMA 0/50 1/50 1/50	May Have Been Related
No	TR-374	556-52-5	Glycidol	Mice	B6C3F1	Female	Gavage	Uterus/Cervix	Clear Evidence	Clear Evidence	CARCINOMA 0/50 0/50 1/50 OR ADENOCARCINOMA 0/50 3/50 2/50 COMBINED 0/50 3/50 3/50	Neoplastic Lesions
No	TR-374	556-52-5	Glycidol	Rats	F344/N	Male	Gavage	Zymbal Gland	Clear Evidence	Clear Evidence	CARCINOMA 1/50 3/50 6/50	Neoplastic Lesions
Yes	TR-366	123-31-9	Hydroquinone	Rats	F344/N	Female	Gavage	Hematopoietic System	Some Evidence	Some Evidence	Leukemia 9/55 15/55 22/55	Neoplastic Lesions
No	TR-366	123-31-9	Hydroquinone	Rats	F344/N	Male	Gavage	Kidney Tubular Cell	Some Evidence	Some Evidence	Adenoma 0/55 4/55 8/55	Neoplastic Lesions
No	TR-366	123-31-9	Hydroquinone	Mice	B6C3F1	Female	Gavage	Liver	Some Evidence	Some Evidence	Adenoma 2/55 15/55 12/55; adenoma or carcinoma (combined) 3/55 16/55 13/55	Neoplastic Lesions
No	TR-078	21416-87-5	ICRF-159	Mice	B6C3F1	Male	Intraperitoneal Injection	Unspecified	Negative		Not applicable	Not applicable
No	TR-078	21416-87-5	ICRF-159	Rats	Sprague Dawley	Male	Intraperitoneal Injection	Unspecified	Negative		Not applicable	Not applicable
Yes	TR-078	21416-87-5	ICRF-159	Mice	B6C3F1	Female	Intraperitoneal Injection	Hematopoietic System	Positive	Positive	(LYMPHOMA)	Neoplastic Lesions
No	TR-078	21416-87-5	ICRF-159	Rats	Sprague Dawley	Female	Intraperitoneal Injection	Uterus/Cervix	Positive	Positive	(ADENOCARCINOMA)	Neoplastic Lesions
No	TR-499	22398-80-7	Indium phosphide	Rats	F344/N	Female	Inhalation	Adrenal Gland Medulla	Clear Evidence	Clear Evidence	BENIGN PHEOCHROMOCYTOMA 2/50 6/48 2/50 9/49	Neoplastic Lesions
No	TR-499	22398-80-7	Indium phosphide	Rats	F344/N	Male	Inhalation	Adrenal Gland Medulla	Clear Evidence	Clear Evidence	BENIGN PHEOCHROMOCYTOMA 10/50 22/50 16/49 23/50 BENIGN OR MALIGNANT PHEOCHROMOCYTOMA 10/50 26/50 18/49 24/50	Neoplastic Lesions
Yes	TR-499	22398-80-7	Indium phosphide	Rats	F344/N	Female	Inhalation	Hematopoietic System	Clear Evidence	Equivocal Evidence	MONONUCLEAR CELL LEUKEMIA 14/50 21/50 14/50 24/50	May Have Been Related
Yes	TR-499	22398-80-7	Indium phosphide	Rats	F344/N	Male	Inhalation	Hematopoietic System	Clear Evidence	Equivocal Evidence	MONONUCLEAR CELL LEUKEMIA 16/50 23/50 29/50 25/50	May Have Been Related
No	TR-499	22398-80-7	Indium phosphide	Mice	B6C3F1	Male	Inhalation	Intestines (Large)	Clear Evidence	Equivocal Evidence	CARCINOMA 0/50 1/50 5/50 3/50; ADEMONA OR CARCINOMA 1/50 2/50 6/50 3/50	May Have Been Related
No	TR-499	22398-80-7	Indium phosphide	Mice	B6C3F1	Female	Inhalation	Liver	Clear Evidence	Clear Evidence	ADENOMA 12/50 14/50 18/50 14/50; CARCINOMA 6/50 17/50 8/50 10/50; COMBINED 18/50 28/50 24/50 23/50	Neoplastic Lesions
No	TR-499	22398-80-7	Indium phosphide	Mice	B6C3F1	Male	Inhalation	Liver	Clear Evidence	Clear Evidence	ADENOMA 17/50 24/50 23/50 32/50; CARCINOMA 11/50 22/50 23/50 16/50; COMBINED 26/50 40/50 37/50 39/50	Neoplastic Lesions
No	TR-499	22398-80-7	Indium phosphide	Mice	B6C3F1	Female	Inhalation	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADEMONA 3/50 6/50 10/50 7/50; ALVEOLAR/BRONCHIOLAR CARCINOMA 1/50 6/50 5/50 7/50; COMBINED 4/50 11/50 15/50 14/50	Neoplastic Lesions
No	TR-499	22398-80-7	Indium phosphide	Mice	B6C3F1	Male	Inhalation	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR CARCINOMA 6/50 15/50 22/50 13/50	Neoplastic Lesions
No	TR-499	22398-80-7	Indium phosphide	Rats	F344/N	Female	Inhalation	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADEMONA 0/50 7/50 5/50 19/50; ALVEOLAR/BRONCHIOLAR CARCINOMA 1/50 3/50 1/50 11/50; COMBINED 1/50 10/50 6/50 26/50	Neoplastic Lesions
No	TR-499	22398-80-7	Indium phosphide	Rats	F344/N	Male	Inhalation	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADEMONA 6/50 13/50 27/50 30/50; ALVEOLAR/BRONCHIOLAR CARCINOMA 1/50 10/50 8/50 16/50; COMBINED 7/50 22/50 30/50 35/50; SQUAMOUS CELL CARCINOMA 0/50 0/50 0/50 4/50	Neoplastic Lesions
No	TR-499	22398-80-7	Indium phosphide	Rats	F344/N	Female	Inhalation	Mammary Gland	Clear Evidence	Equivocal Evidence	CARCINOMA 0/50 8/50 3/50 2/50	May Have Been Related
No	TR-499	22398-80-7	Indium phosphide	Rats	F344/N	Male	Inhalation	Skin	Clear Evidence	Equivocal Evidence	FIBROMA 1/50 4/50 7/50 3/50; FIBROMA OR FIBROSARCOMA 2/50 4/50 8/50 4/50	May Have Been Related
No	TR-340	5634-39-9	Iodinated glycerol	Mice	B6C3F1	Female	Gavage	Forestomach	Some Evidence	Equivocal Evidence	SQUAMOUS CELL PAPILLOMA 1/49 2/50 5/49	May Have Been Related
No	TR-340	5634-39-9	Iodinated glycerol	Mice	B6C3F1	Female	Gavage	Harderian Gland	Some Evidence	Some Evidence	ADENOMA 6/50 8/40 13/50 OR CARCINOMA 0/50 0/40 1/50 COMBINED 6/50 8/40 14/50	Neoplastic Lesions
Yes	TR-340	5634-39-9	Iodinated glycerol	Rats	F344/N	Male	Gavage	Hematopoietic System	Some Evidence	Some Evidence	LEUKEMIA 14/50 29/50 24/50	Neoplastic Lesions
No	TR-340	5634-39-9	Iodinated glycerol	Rats	F344/N	Male	Gavage	Nasal Cavity	Some Evidence	Equivocal Evidence	ADENOMA 0/48 0/47 2/49	May Have Been Related
No	TR-340	5634-39-9	Iodinated glycerol	Mice	B6C3F1	Female	Gavage	Pituitary Gland	Some Evidence	Some Evidence	ADENOMA 10/47 15/45 24/46	Neoplastic Lesions
No	TR-340	5634-39-9	Iodinated glycerol	Rats	F344/N	Male	Gavage	Thyroid Gland Follicular Cell	Some Evidence	Some Evidence	CARCINOMA 0/49 5/49 1/49	Neoplastic Lesions
No	TR-032	3778-73-2	Isophosphamide	Mice	B6C3F1	Male	Intraperitoneal Injection	Unspecified	Negative		Not applicable	Not applicable
No	TR-032	3778-73-2	Isophosphamide	Rats	Sprague Dawley	Male	Intraperitoneal Injection	Unspecified	Negative		Not applicable	Not applicable
Yes	TR-032	3778-73-2	Isophosphamide	Mice	B6C3F1	Female	Intraperitoneal Injection	Hematopoietic System	Positive	Positive	(LYMPHOMA)	Neoplastic Lesions
No	TR-032	3778-73-2	Isophosphamide	Rats	Sprague Dawley	Female	Intraperitoneal Injection	Mammary Gland	Positive	Positive	(FIBROADENOMA)	Neoplastic Lesions
No	TR-032	3778-73-2	Isophosphamide	Rats	Sprague Dawley	Female	Intraperitoneal Injection	Uterus/Cervix	Positive	Positive	(LEIOMYOSARCOMA)	Neoplastic Lesions
Yes	TR-039	303-34-4	Lasiocarpine	Rats	F344/N	Female	Dosed-Feed	Hematopoietic System	Positive	Positive	Lymphoma/Leukemia	Neoplastic Lesions
No	TR-039	303-34-4	Lasiocarpine	Rats	F344/N	Female	Dosed-Feed	Liver	Positive	Positive	Angiosarcoma, carcinoma, adenoma	Neoplastic Lesions
No	TR-039	303-34-4	Lasiocarpine	Rats	F344/N	Male	Dosed-Feed	Liver	Positive	Positive	Angiosarcoma, carcinoma, adenoma	Neoplastic Lesions
Yes	TR-538	108-10-1	Methyl isobutyl ketone	Rats	F344/N	Male	Inhalation	Hematopoietic System	Some Evidence	Equivocal Evidence	MONONUCLEAR CELL LEUKEMIA 25/50 26/50 32/50 35/50	May Have Been Related
No	TR-538	108-10-1	Methyl isobutyl ketone	Rats	F344/N	Female	Inhalation	Kidney Mesenchymal Cell	Equivocal Evidence	Equivocal Evidence	TUMOR MALIGNANT 0/50 0/50 0/50 2/50	Neoplastic Lesions
No	TR-538	108-10-1	Methyl isobutyl ketone	Rats	F344/N	Male	Inhalation	Kidney Tubular Cell	Some Evidence	Some Evidence	ADENOMA (STANDARD EVALUATION - 0/50 0/50 2/50 3/50; STANDARD AND EXTENDED EVAULATION COMBINED - 2/50 3/50 3/50 10/50); CARCINOMA (STANDARD EVALUATION - 0/50 1/50 0/50 2/50); ADENOMA OR CARCINOMA (COMBINED) (STANDARD EVAULATION - 0/50 1/50 2/50 4/50; STANDARD AND EXTENDED EVALUATION - 2/50 4/50 3/50 11/50)	Neoplastic Lesions
No	TR-538	108-10-1	Methyl isobutyl ketone	Mice	B6C3F1	Female	Inhalation	Liver	Some Evidence	Some Evidence	ADENOMA 13/50 15/50 20/50 23/50 ADENOMA OR CARCINOMA (COMBINED) 17/50 17/50 22/50 27/50	Neoplastic Lesions
No	TR-538	108-10-1	Methyl isobutyl ketone	Mice	B6C3F1	Male	Inhalation	Liver	Some Evidence	Some Evidence	ADENOMA 17/50 25/50 23/50 34/50 ADENOMA OR CARCINOMA (COMBINED) 27/50 34/50 28/50 37/50	Neoplastic Lesions
No	TR-540	7220-79-3	Methylene blue trihydrate	Mice	B6C3F1	Female	Gavage	Hematopoietic System	Equivocal Evidence	Equivocal Evidence	MALIGNANT LYMPHOMA 6/50 4/50 9/50 12/50	May Have Been Related
Yes	TR-540	7220-79-3	Methylene blue trihydrate	Mice	B6C3F1	Male	Gavage	Hematopoietic System	Some Evidence	Equivocal Evidence	MALIGNANT LYMPHOMA 2/50 2/50 2/50 5/50	May Have Been Related
No	TR-540	7220-79-3	Methylene blue trihydrate	Mice	B6C3F1	Male	Gavage	Intestines (Small)	Some Evidence	Some Evidence	CARCINOMA 0/50 1/50 2/50 4/50 ADENOMA OR CARCINOMA 1/50 2/50 4/50 6/50	Neoplastic Lesions
No	TR-540	7220-79-3	Methylene blue trihydrate	Rats	F344/N	Male	Gavage	Pancreas Islet Cell	Some Evidence	Some Evidence	ADENOMA 4/50 9/50 12/50 8/50 ADENOMA OR CARCINOMA 4/50 9/50 14/50 8/50	Neoplastic Lesions
No	TR-313	2385-85-5	Mirex	Rats	F344/N	Male	Dosed-Feed	Adrenal Gland Medulla	Clear Evidence	Clear Evidence	PHEOCHROMOCYTOMA 8/51 7/52 13/52 11/52 18/51 19/51	Neoplastic Lesions
Yes	TR-313	2385-85-5	Mirex	Rats	F344/N	Female	Dosed-Feed	Hematopoietic System	Clear Evidence	Clear Evidence	LEUKEMIA 6/52 9/52 14/52	Neoplastic Lesions
No	TR-313	2385-85-5	Mirex	Rats	F344/N	Male	Dosed-Feed	Kidney Transitional Cell	Clear Evidence	Clear Evidence	PAPILLOMA 0/51 0/51 0/52 0/52 1/51 3/52	Neoplastic Lesions
No	TR-313	2385-85-5	Mirex	Rats	F344/N	Female	Dosed-Feed	Liver	Clear Evidence	Clear Evidence	NEOPLASTIC NODULE 2/52 23/52 30/52	Neoplastic Lesions
No	TR-313	2385-85-5	Mirex	Rats	F344/N	Male	Dosed-Feed	Liver	Clear Evidence	Clear Evidence	NEOPLASTIC NODULE 3/52 5/52 5/52 14/52 15/52 26/52	Neoplastic Lesions
No	TR-416	91-23-6	o-Nitroanisole	Rats	F344/N	Female	Dosed-Feed	Forestomach	Clear Evidence	Equivocal Evidence	SQUAMOUS CELL PAPILLOMA 0/50 1/50 0/50 1/50	May Have Been Related
No	TR-416	91-23-6	o-Nitroanisole	Rats	F344/N	Male	Dosed-Feed	Forestomach	Clear Evidence	Equivocal Evidence	SQUAMOUS CELL PAPILLOMA O/50 0/50 1/50 1/50; SQUAMOUS CELL CARCINOMA 0/50 0/50 1/50 1/50	May Have Been Related
Yes	TR-416	91-23-6	o-Nitroanisole	Rats	F344/N	Female	Dosed-Feed	Hematopoietic System	Clear Evidence	Clear Evidence	MONONUCLEAR CELL LEUKEMIA 14/50 11/50 14/50 26/50	Neoplastic Lesions
Yes	TR-416	91-23-6	o-Nitroanisole	Rats	F344/N	Male	Dosed-Feed	Hematopoietic System	Clear Evidence	Clear Evidence	MONONUCLEAR CELL LEUKEMIA 26/50 25/50 42/50 34/50	Neoplastic Lesions
No	TR-416	91-23-6	o-Nitroanisole	Rats	F344/N	Female	Dosed-Feed	Intestines (Large)	Clear Evidence	Clear Evidence	(STOP STUDY) ADENOMATOUS POLYP 0/60 8/60 18/60, CARCINOMA 0/60 0/60 2/60	Neoplastic Lesions
No	TR-416	91-23-6	o-Nitroanisole	Rats	F344/N	Male	Dosed-Feed	Intestines (Large)	Clear Evidence	Clear Evidence	(STOP STUDY) ADENOMATOUS POLYP 0/60 26/60 30/60, CARCINOMA 0/60 0/60 5/60	Neoplastic Lesions
No	TR-416	91-23-6	o-Nitroanisole	Rats	F344/N	Female	Dosed-Feed	Kidney Transitional Cell	Clear Evidence	Clear Evidence	(STOP STUDY) PAPILLOMA 0/60 0/60 1/60 OR CARCINOMA 0/60 0/60 1/60	Neoplastic Lesions
No	TR-416	91-23-6	o-Nitroanisole	Rats	F344/N	Male	Dosed-Feed	Kidney Transitional Cell	Clear Evidence	Clear Evidence	PAPILLOMA (STOP STUDY) 0/60 0/60 4/60 OR CARCINOMA 0/60 1/60 8/60	Neoplastic Lesions
No	TR-416	91-23-6	o-Nitroanisole	Rats	F344/N	Male	Dosed-Feed	Kidney Tubular Cell	Clear Evidence	Equivocal Evidence	ADENOMA 0/49 1/50 1/50 1/49 OR CARCINOMA 0/49 0/50 0/50 2/49	May Have Been Related
No	TR-416	91-23-6	o-Nitroanisole	Mice	B6C3F1	Male	Dosed-Feed	Liver	Clear Evidence	Clear Evidence	ADENOMA 14/50 26/50 41/50 29/50; CARCINOMA 7/50 12/50 11/50 7/50; HEPATOBLASTOMA 0/50 3/50 17/50 9/50	Neoplastic Lesions
No	TR-416	91-23-6	o-Nitroanisole	Mice	B6C3F1	Female	Dosed-Feed	Liver	Some Evidence	Some Evidence	ADENOMA 14/50 2/50 36/50 18/50	Neoplastic Lesions
No	TR-416	91-23-6	o-Nitroanisole	Rats	F344/N	Female	Dosed-Feed	Urinary Bladder	Clear Evidence	Clear Evidence	(STOP STUDY) TRANSITIONAL CELL PAPILLOMA 0/58 2/59 1/60, TRANSITIONAL CELL CARCINOMA 0/58 28/59 48/60	Neoplastic Lesions
No	TR-416	91-23-6	o-Nitroanisole	Rats	F344/N	Male	Dosed-Feed	Urinary Bladder	Clear Evidence	Clear Evidence	(STOP STUDY) TRANSITIONAL CELL PAPILLOMA 0/59 9/59 1/60, TRANSITIONAL CELL CARCINOMA 0/59 27/59 50/60, SQUAMOUS CELL PAPILLOMA 0/59 0/59 4/60, SQUAMOUS CELL CARCINOMA 0/59 0/59 6/60, SARCOMA 0/59 2/59 9/60	Neoplastic Lesions
Yes	TR-504	88-72-2	o-Nitrotoluene	Mice	B6C3F1	Female	Dosed-Feed	Hematopoietic System	Clear Evidence	Clear Evidence	HEMANGIOSARCOMA 0/60 2/60 3/60 50/60	Neoplastic Lesions
Yes	TR-504	88-72-2	o-Nitrotoluene	Mice	B6C3F1	Male	Dosed-Feed	Hematopoietic System	Clear Evidence	Clear Evidence	HEMANGIOSARCOMA 4/60 17/60 55/60 60/60	Neoplastic Lesions
No	TR-504	88-72-2	o-Nitrotoluene	Mice	B6C3F1	Female	Dosed-Feed	Intestines (Large)	Clear Evidence	Clear Evidence	(CECUM) CARCINOMA 0/60 1/60 4/60 3/60	Neoplastic Lesions
No	TR-504	88-72-2	o-Nitrotoluene	Mice	B6C3F1	Male	Dosed-Feed	Intestines (Large)	Clear Evidence	Clear Evidence	(CECUM) CARCINOMA 0/60 12/60 9/60 0/60	Neoplastic Lesions
No	TR-504	88-72-2	o-Nitrotoluene	Rats	F344/N	Female	Dosed-Feed	Liver	Clear Evidence	Equivocal Evidence	ADENOMA 1/60 0/59 1/60 6/60	May Have Been Related
No	TR-504	88-72-2	o-Nitrotoluene	Mice	B6C3F1	Female	Dosed-Feed	Liver	Clear Evidence	Clear Evidence	ADENOMA 7/60 5/59 19/59 29/60 CARCINOMA 2/60 4/59 6/59 16/60 COMBINED 9/60 9/59 24/59 39/60	Neoplastic Lesions
No	TR-504	88-72-2	o-Nitrotoluene	Rats	F344/N	Male	Dosed-Feed	Liver	Clear Evidence	Clear Evidence	ADENOMA 2/60 3/60 3/60 7/60 3/60 4/60 ADENOMA OR CARCINOMA 3/60 3/60 3/60 8/60 3/60 6/60 CHOLANGIOCARCINOMA 0/60 0/60 0/60 0/60 0/60 3/60 HEPATOCHOLANGIOCARCINOMA 0/60 1/60 0/60 1/60 0/60 0/60	Neoplastic Lesions
No	TR-504	88-72-2	o-Nitrotoluene	Rats	F344/N	Male	Dosed-Feed	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 1/60 5/60 1/60 2/60 3/60 8/60 OR ALVEOLAR/BRONCHIOLAR ADENOMA OR CARCINOMA 2/60 5/60 1/60 2/60 3/60 11/60	Neoplastic Lesions
No	TR-504	88-72-2	o-Nitrotoluene	Rats	F344/N	Female	Dosed-Feed	Mammary Gland	Clear Evidence	Clear Evidence	FIBROADENOMA 23/60 47/60 52/60 56/60	Neoplastic Lesions
No	TR-504	88-72-2	o-Nitrotoluene	Rats	F344/N	Male	Dosed-Feed	Mammary Gland	Clear Evidence	Clear Evidence	FIBROADENOMA 0/60 7/60 10/60 2/60 13/60 20/60	Neoplastic Lesions
No	TR-504	88-72-2	o-Nitrotoluene	Rats	F344/N	Male	Dosed-Feed	Mesothelium (Abdominal Cavity/Tunica Vaginalis)	Clear Evidence	Clear Evidence	MALIGNANT MESOTHELIOMA 2/60 20/60 29/60 44/60 44/60 54/60	Neoplastic Lesions
No	TR-504	88-72-2	o-Nitrotoluene	Rats	F344/N	Female	Dosed-Feed	Skin	Clear Evidence	Clear Evidence	(SUBCUTANEOUS) FIBROMA 3/60 3/60 18/60 20/60 FIBROMA OR FIBROSARCOMA 3/60 3/60 21/60 22/60	Neoplastic Lesions
No	TR-504	88-72-2	o-Nitrotoluene	Rats	F344/N	Male	Dosed-Feed	Skin	Clear Evidence	Clear Evidence	(SUBCUTANEOUS) LIPOMA 0/60 4/60 13/60 13/60 10/60 12/60 FIBROMA 5/60 46/60 52/60 59/60 45/60 52/60 FIBROSARCOMA 0/60 7/60 17/60 20/60 8/60 12/60 COMBINED 5/60 47/60 55/60 59/60 47/60 53/60	Neoplastic Lesions
No	TR-060	3546-10-9	Phenesterin	Rats	Sprague Dawley	Male	Gavage	Unspecified	Negative		Not applicable	Not applicable
No	TR-060	3546-10-9	Phenesterin	Mice	B6C3F1	Female	Gavage	Heart	Positive	Positive	(SARCOMA)	Neoplastic Lesions
No	TR-060	3546-10-9	Phenesterin	Mice	B6C3F1	Male	Gavage	Heart	Positive	Positive	(SARCOMA)	Neoplastic Lesions
Yes	TR-060	3546-10-9	Phenesterin	Mice	B6C3F1	Female	Gavage	Hematopoietic System	Positive	Positive	(LYMPHOMA)	Neoplastic Lesions
Yes	TR-060	3546-10-9	Phenesterin	Mice	B6C3F1	Male	Gavage	Hematopoietic System	Positive	Positive	(LYMPHOMA)	Neoplastic Lesions
No	TR-060	3546-10-9	Phenesterin	Mice	B6C3F1	Female	Gavage	Lung	Positive	Positive	(ALVEOLAR/BRONCHIOLAR CARCINOMA)	Neoplastic Lesions
No	TR-060	3546-10-9	Phenesterin	Mice	B6C3F1	Male	Gavage	Lung	Positive	Positive	(ALVEOLAR/BRONCHIOLAR CARCINOMA)	Neoplastic Lesions
No	TR-060	3546-10-9	Phenesterin	Rats	Sprague Dawley	Female	Gavage	Mammary Gland	Positive	Positive	(ADENOCARCINOMA)	Neoplastic Lesions
No	TR-465	77-09-8	Phenolphthalein	Rats	F344/N	Male	Dosed-Feed	Adrenal Gland Medulla	Clear Evidence	Clear Evidence	PHEOCHROMOCYTOMA 17/50 34/50 34/50 34/50	Neoplastic Lesions
No	TR-465	77-09-8	Phenolphthalein	Rats	F344/N	Female	Dosed-Feed	Adrenal Gland Medulla	Some Evidence	Some Evidence	PHEOCHROMOCYTOMA 3/50 11/50 9/50 2/49 OR MALIGNANT PHEOCHROMOCYTOMA 0/50 1/50 1/50 0/50 COMBINED 3/50 12/50 10/50 2/49	Neoplastic Lesions
Yes	TR-465	77-09-8	Phenolphthalein	Mice	B6C3F1	Female	Dosed-Feed	Hematopoietic System	Clear Evidence	Clear Evidence	HISTIOCYTIC SARCOMA 0/50 2/50 7/50 7/50; LYMPHOMA 15/50 28/50 33/5 25/50; LYMPHOMA (THYMIC ORIGIN) 1/50 9/50 10/50 7/50	Neoplastic Lesions
Yes	TR-465	77-09-8	Phenolphthalein	Mice	B6C3F1	Male	Dosed-Feed	Hematopoietic System	Clear Evidence	Clear Evidence	HISTIOCYTIC SARCOMA 1/50 3/50 11/50 12/49; LYMPHOMA (THYMIC ORIGIN) 0/50 4/50 7/50 2/49	Neoplastic Lesions
No	TR-465	77-09-8	Phenolphthalein	Rats	F344/N	Male	Dosed-Feed	Kidney Tubular Cell	Clear Evidence	Clear Evidence	(SINGLE SECTIONS) ADENOMA 0/50 4/50 2/50 6/50 OR CARCINOMA 0/50 1/50 1/50 2/50 COMBINED 0/50 5/50 3/50 7/50; (SINGLE AND STEP SECTIONS) ADENOMA 1/50 10/50 15/50 15/50 OR CARCINOMA 0/50 1/50 2/50 2/50 COMBINED 1/50 10/50 16/50 16/50	Neoplastic Lesions
No	TR-465	77-09-8	Phenolphthalein	Mice	B6C3F1	Female	Dosed-Feed	Ovary	Clear Evidence	Clear Evidence	BENIGN SEX-CORD STROMAL TUMOR 0/50 7/49 6/50 5/50	Neoplastic Lesions
No	TR-019	366-70-1	Procarbazine hydrochloride	Mice	B6C3F1	Female	Intraperitoneal Injection	Brain	Positive	Positive	(NEUROBLASTOMA)	Neoplastic Lesions
No	TR-019	366-70-1	Procarbazine hydrochloride	Mice	B6C3F1	Male	Intraperitoneal Injection	Brain	Positive	Positive	(NEUROBLASTOMA)	Neoplastic Lesions
No	TR-019	366-70-1	Procarbazine hydrochloride	Rats	Sprague Dawley	Female	Intraperitoneal Injection	Brain	Positive	Positive	(NEUROBLASTOMA)	Neoplastic Lesions
No	TR-019	366-70-1	Procarbazine hydrochloride	Rats	Sprague Dawley	Male	Intraperitoneal Injection	Brain	Positive	Positive	(ADENOCARCINOMA, NEUROBLASTOMA, CARCINOMA)	Neoplastic Lesions
Yes	TR-019	366-70-1	Procarbazine hydrochloride	Mice	B6C3F1	Female	Intraperitoneal Injection	Hematopoietic System	Positive	Positive	(LYMPHOMA OR LEUKEMIA)	Neoplastic Lesions
Yes	TR-019	366-70-1	Procarbazine hydrochloride	Mice	B6C3F1	Male	Intraperitoneal Injection	Hematopoietic System	Positive	Positive	(LYMPHOMA OR LEUKEMIA)	Neoplastic Lesions
Yes	TR-019	366-70-1	Procarbazine hydrochloride	Rats	Sprague Dawley	Female	Intraperitoneal Injection	Hematopoietic System	Positive	Positive	(LYMPHOMA)	Neoplastic Lesions
Yes	TR-019	366-70-1	Procarbazine hydrochloride	Rats	Sprague Dawley	Male	Intraperitoneal Injection	Hematopoietic System	Positive	Positive	(LYMPHOMA OR LEUKEMIA)	Neoplastic Lesions
No	TR-019	366-70-1	Procarbazine hydrochloride	Mice	B6C3F1	Female	Intraperitoneal Injection	Lung	Positive	Positive	(ALVEOLAR/BRONCHIOLAR ADENOMA)	Neoplastic Lesions
No	TR-019	366-70-1	Procarbazine hydrochloride	Mice	B6C3F1	Male	Intraperitoneal Injection	Lung	Positive	Positive	(ALVEOLAR/BRONCHIOLAR ADENOMA)	Neoplastic Lesions
No	TR-019	366-70-1	Procarbazine hydrochloride	Rats	Sprague Dawley	Female	Intraperitoneal Injection	Mammary Gland	Positive	Positive	(ADENOCARCINOMA)	Neoplastic Lesions
No	TR-019	366-70-1	Procarbazine hydrochloride	Rats	Sprague Dawley	Male	Intraperitoneal Injection	Mammary Gland	Positive	Positive	(ADENOCARCINOMA)	Neoplastic Lesions
No	TR-019	366-70-1	Procarbazine hydrochloride	Mice	B6C3F1	Female	Intraperitoneal Injection	Uterus/Cervix	Positive	Positive	(ADENOCARCINOMA)	Neoplastic Lesions
Yes	TR-508	23246-96-0	Riddelliine	Rats	F344/N	Female	Gavage	Hematopoietic System	Clear Evidence	Clear Evidence	MONONUCLEAR CELL LEUKEMIA (ALL ORGANS) 12/50 8/50 13/50 18/50 18/50 14/50	Neoplastic Lesions
Yes	TR-508	23246-96-0	Riddelliine	Rats	F344/N	Male	Gavage	Hematopoietic System	Clear Evidence	Clear Evidence	Hematopoietic System: MONONUCLEAR CELL LEUKEMIA (ALL ORGANS) 2/50 9/50	Neoplastic Lesions
No	TR-508	23246-96-0	Riddelliine	Mice	B6C3F1	Male	Gavage	Liver	Clear Evidence	Clear Evidence	HEMANGIOSARCOMA 2/50 1/50 0/50 2/50 31/50	Neoplastic Lesions
No	TR-508	23246-96-0	Riddelliine	Rats	F344/N	Female	Gavage	Liver	Clear Evidence	Clear Evidence	HEMANGIOSARCOMA 0/50 0/50 0/50 0/50 3/50 38/50; ADENOMA 1/50 0/50 0/50 0/50 1/50 7/50	Neoplastic Lesions
No	TR-508	23246-96-0	Riddelliine	Rats	F344/N	Male	Gavage	Liver	Clear Evidence	Clear Evidence	HEMANGIOSARCOMA 0/50 43/50; ADENOMA 0/50 4/50	Neoplastic Lesions
No	TR-508	23246-96-0	Riddelliine	Mice	B6C3F1	Female	Gavage	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 1/50 9/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 1/50 4/50 COMBINED 2/50 13/50	Neoplastic Lesions
Yes	TR-311	127-18-4	Tetrachloroethylene	Rats	F344/N	Male	Inhalation	Hematopoietic System	Clear Evidence	Clear Evidence	LEUKEMIA 28/50 37/50 37/50	Neoplastic Lesions
Yes	TR-311	127-18-4	Tetrachloroethylene	Rats	F344/N	Female	Inhalation	Hematopoietic System	Some Evidence	Some Evidence	LEUKEMIA 18/50 30/50 29/50	Neoplastic Lesions
No	TR-311	127-18-4	Tetrachloroethylene	Rats	F344/N	Male	Inhalation	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA 1/49 3/49 2/50 OR ADENOCARCINOMA 0/49 0/49 2/50 COMBINED 1/49 3/49 4/50	Neoplastic Lesions
No	TR-311	127-18-4	Tetrachloroethylene	Mice	B6C3F1	Female	Inhalation	Liver	Clear Evidence	Clear Evidence	CARCINOMA 1/48 13/50 36/50	Neoplastic Lesions
No	TR-311	127-18-4	Tetrachloroethylene	Mice	B6C3F1	Male	Inhalation	Liver	Clear Evidence	Clear Evidence	ADENOMA 11/49 8/49 18/50; CARCINOMA 7/49 25/49 26/50	Neoplastic Lesions
Yes	TR-450	116-14-3	Tetrafluoroethylene	Rats	F344/N	Male	Inhalation	Hematopoietic System	Clear Evidence	Equivocal Evidence	MONONUCLEAR CELL LEUKEMIA: 34/50 43/50 38/50 31/50	May Have Been Related
Yes	TR-450	116-14-3	Tetrafluoroethylene	Mice	B6C3F1	Female	Inhalation	Hematopoietic System	Clear Evidence	Clear Evidence	HISTIOCYTIC SARCOMA 1/48 21/48 19/47 18/48	Neoplastic Lesions
Yes	TR-450	116-14-3	Tetrafluoroethylene	Mice	B6C3F1	Male	Inhalation	Hematopoietic System	Clear Evidence	Clear Evidence	HISTIOCYTIC SARCOMA 0/48 12/48 7/48 7/48	Neoplastic Lesions
Yes	TR-450	116-14-3	Tetrafluoroethylene	Rats	F344/N	Female	Inhalation	Hematopoietic System	Clear Evidence	Clear Evidence	MONONUCLEAR CELL LEUKEMIA: 16/50 31/50 23/50 36/50	Neoplastic Lesions
No	TR-450	116-14-3	Tetrafluoroethylene	Rats	F344/N	Female	Inhalation	Kidney Tubular Cell	Clear Evidence	Clear Evidence	SINGLE SECTIONS: ADENOMA 0/50 3/50 1/50 3/50 OR CARCINOMA 0/50 0/50 0/50 2/50 COMBINED 0/50 3/50 1/50 5/50; SINGLE AND STEP SECTIONS: ADENOMA 0/50 3/50 3/50 8/50 OR CARCINOMA 0/50 0/50 0/50 3/50 COMBINED 0/50 3/50 3/50 10/50	Neoplastic Lesions
No	TR-450	116-14-3	Tetrafluoroethylene	Rats	F344/N	Male	Inhalation	Kidney Tubular Cell	Clear Evidence	Clear Evidence	SINGLE SECTIONS: ADENOMA 0/50 0/50 6/50 3/50 OR CARCINOMA 1/50 0/50 2/50 0/50 COMBINED 1/50 0/50 6/50 3/50; SINGLE AND STEP SECTIONS: ADENOMA 2/50 4/50 9/50 13/50 OR CARCINOMA 1/50 1/50 2/50 0/50 COMBINED 3/50 5/50 9/50 13/50	Neoplastic Lesions
No	TR-450	116-14-3	Tetrafluoroethylene	Mice	B6C3F1	Female	Inhalation	Liver	Clear Evidence	Clear Evidence	ADENOMA 15/48 17/48 20/47 15/47 OR CARCINOMA 4/48 28/48 22/47 20/47 COMBINED 17/48 33/48 29/47 28/47	Neoplastic Lesions
No	TR-450	116-14-3	Tetrafluoroethylene	Mice	B6C3F1	Male	Inhalation	Liver	Clear Evidence	Clear Evidence	ADENOMA 17/48 17/48 12/48 20/48 OR CARCINOMA 11/48 20/48 33/48 26/48 COMBINED 26/48 34/48 39/48 35/48	Neoplastic Lesions
No	TR-450	116-14-3	Tetrafluoroethylene	Rats	F344/N	Female	Inhalation	Liver	Clear Evidence	Clear Evidence	ADENOMA 0/50 4/50 5/50 6/50 OR CARCINOMA 0/50 4/50 9/50 2/50 COMBINED 0/50 7/50 12/50 8/50	Neoplastic Lesions
No	TR-450	116-14-3	Tetrafluoroethylene	Rats	F344/N	Male	Inhalation	Liver	Clear Evidence	Clear Evidence	ADENOMA 3/50 6/50 8/50 5/50 OR CARCINOMA 1/50 1/50 10/50 3/50 COMBINED 4/50 7/50 15/50 8/50	Neoplastic Lesions
No	TR-450	116-14-3	Tetrafluoroethylene	Rats	F344/N	Male	Inhalation	Testis	Clear Evidence	Equivocal Evidence	INTERSTITIAL CELL ADENOMA 39/50 40/50 48/50 47/50	May Have Been Related
No	TR-450	116-14-3	Tetrafluoroethylene	Mice	B6C3F1	Female	Inhalation	Vascular System (Liver)	Clear Evidence	Clear Evidence	HEMANGIOMA 0/48 5/48 2/47 1/47 OR HEMANGIOSARCOMA 0/48 27/48 27/47 34/47 COMBINED 0/48 31/48 28/47 35/47	Neoplastic Lesions
No	TR-450	116-14-3	Tetrafluoroethylene	Mice	B6C3F1	Male	Inhalation	Vascular System (Liver)	Clear Evidence	Clear Evidence	HEMANGIOMA 0/48 10/48 5/48 2/48 OR HEMANGIOSARCOMA 0/48 21/48 27/48 37/48 COMBINED 0/48 26/48 30/48 38/48	Neoplastic Lesions
No	TR-450	116-14-3	Tetrafluoroethylene	Rats	F344/N	Female	Inhalation	Vascular System (Liver)	Clear Evidence	Clear Evidence	HEMANGIOSARCOMA 0/50 0/50 5/50 1/50	Neoplastic Lesions
No	TR-391	115-96-8	Tris(2-Chloroethyl) Phosphate	Mice	B6C3F1	Female	Gavage	Harderian Gland	Equivocal Evidence	Equivocal Evidence	ADENOMA 3/50 7/50 7/50 OR CARCINOMA 0/50 1/50 0/50 COMBINED 3/50 8/50 7/50	Neoplastic Lesions
Yes	TR-391	115-96-8	Tris(2-Chloroethyl) Phosphate	Rats	F344/N	Female	Gavage	Hematopoietic System	Clear Evidence	Equivocal Evidence	MONONUCLEAR CELL LEUKEMIA 14/50 16/50 20/50	May Have Been Related
Yes	TR-391	115-96-8	Tris(2-Chloroethyl) Phosphate	Rats	F344/N	Male	Gavage	Hematopoietic System	Clear Evidence	Equivocal Evidence	MONONUCLEAR CELL LEUKEMIA 5/50 14/50 13/50	May Have Been Related
No	TR-391	115-96-8	Tris(2-Chloroethyl) Phosphate	Rats	F344/N	Female	Gavage	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 2/50 5/50	Neoplastic Lesions
No	TR-391	115-96-8	Tris(2-Chloroethyl) Phosphate	Rats	F344/N	Male	Gavage	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA 1/50 5/50 24/50	Neoplastic Lesions
No	TR-391	115-96-8	Tris(2-Chloroethyl) Phosphate	Mice	B6C3F1	Male	Gavage	Kidney Tubular Cell	Equivocal Evidence	Equivocal Evidence	ADENOMA 1/50 1/50 3/50	Neoplastic Lesions
No	TR-391	115-96-8	Tris(2-Chloroethyl) Phosphate	Rats	F344/N	Female	Gavage	Thyroid Gland Follicular Cell	Clear Evidence	Equivocal Evidence	ADENOMA 1/50 1/50 1/50 OR CARCINOMA 0/50 2/50 3/50 COMBINED 1/50 3/50 4/50	May Have Been Related
No	TR-391	115-96-8	Tris(2-Chloroethyl) Phosphate	Rats	F344/N	Male	Gavage	Thyroid Gland Follicular Cell	Clear Evidence	Equivocal Evidence	ADENOMA 1/50 2/48 3/50 OR CARCINOMA 0/50 0/48 2/50 COMBINED 1/50 2/48 5/50	May Have Been Related
Yes	TR-058	52-24-4	tris(Aziridinyl)-phosphine sulfide (Thio-TEPA)	Mice	B6C3F1	Female	Intraperitoneal Injection	Hematopoietic System	Positive	Positive	(LYMPHOMA, LEUKEMIA)	Neoplastic Lesions
Yes	TR-058	52-24-4	tris(Aziridinyl)-phosphine sulfide (Thio-TEPA)	Mice	B6C3F1	Male	Intraperitoneal Injection	Hematopoietic System	Positive	Positive	(LYMPHOMA, LEUKEMIA)	Neoplastic Lesions
Yes	TR-058	52-24-4	tris(Aziridinyl)-phosphine sulfide (Thio-TEPA)	Rats	Sprague Dawley	Male	Intraperitoneal Injection	Hematopoietic System	Positive	Positive	(LYMPHOMA OR LEUKEMIA)	Neoplastic Lesions
No	TR-058	52-24-4	tris(Aziridinyl)-phosphine sulfide (Thio-TEPA)	Mice	B6C3F1	Male	Intraperitoneal Injection	Preputial Gland	Positive	Positive	(SQUAMOUS CELL CARCINOMA)	Neoplastic Lesions
No	TR-058	52-24-4	tris(Aziridinyl)-phosphine sulfide (Thio-TEPA)	Mice	B6C3F1	Male	Intraperitoneal Injection	Skin	Positive	Positive	(SQUAMOUS CELL CARCINOMA)	Neoplastic Lesions
No	TR-058	52-24-4	tris(Aziridinyl)-phosphine sulfide (Thio-TEPA)	Rats	Sprague Dawley	Female	Intraperitoneal Injection	Skin	Positive	Positive	(SQUAMOUS CELL CARCINOMA)	Neoplastic Lesions
No	TR-058	52-24-4	tris(Aziridinyl)-phosphine sulfide (Thio-TEPA)	Rats	Sprague Dawley	Male	Intraperitoneal Injection	Skin	Positive	Positive	(SQUAMOUS CELL CARCINOMA)	Neoplastic Lesions
No	TR-058	52-24-4	tris(Aziridinyl)-phosphine sulfide (Thio-TEPA)	Rats	Sprague Dawley	Female	Intraperitoneal Injection	Zymbal Gland	Positive	Positive	(SQUAMOUS CELL CARCINOMA)	Neoplastic Lesions
No	TR-058	52-24-4	tris(Aziridinyl)-phosphine sulfide (Thio-TEPA)	Rats	Sprague Dawley	Male	Intraperitoneal Injection	Zymbal Gland	Positive	Positive	(SQUAMOUS CELL CARCINOMA)	Neoplastic Lesions
Yes	TR-537	631-64-1	Water disinfection byproducts (Dibromoacetic acid)	Rats	F344/N	Female	Dosed-Water	Hematopoietic System	Some Evidence	Some Evidence	MONONUCLEAR CELL LEUKEMIA (ALL ORGANS) 11/50 13/50 16/50 22/50	Neoplastic Lesions
Yes	TR-537	631-64-1	Water disinfection byproducts (Dibromoacetic acid)	Rats	F344/N	Male	Dosed-Water	Hematopoietic System	Some Evidence	Some Evidence	MALIGNANT MESOTHELIOMA (ALL ORGANS) 3/50 1/50 0/50 10/50	Neoplastic Lesions
No	TR-537	631-64-1	Water disinfection byproducts (Dibromoacetic acid)	Mice	B6C3F1	Female	Dosed-Water	Liver	Clear Evidence	Clear Evidence	ADENOMA 19/49 26/50 32/50 35/49 CARCINOMA 3/49 3/50 12/50 8/49 COMBINED 22/49 28/50 37/50 37/49	Neoplastic Lesions
No	TR-537	631-64-1	Water disinfection byproducts (Dibromoacetic acid)	Mice	B6C3F1	Male	Dosed-Water	Liver	Clear Evidence	Clear Evidence	ADENOMA 18/49 37/50 37/50 42/50 CARCINOMA 14/49 9/50 19/50 26/50 COMBINED 28/49 41/50 42/50 47/50 HEPATOBLASTOMA 0/49 4/50 6/50 18/50	Neoplastic Lesions
No	TR-537	631-64-1	Water disinfection byproducts (Dibromoacetic acid)	Mice	B6C3F1	Female	Dosed-Water	Lung	Clear Evidence	Equivocal Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 1/50 3/50 3/50 6/50 ALVEOLAR/BRONCHIOLAR ADENOMA OR CARCINOMA 2/50 5/50 5/50 7/50	May Have Been Related
No	TR-537	631-64-1	Water disinfection byproducts (Dibromoacetic acid)	Mice	B6C3F1	Male	Dosed-Water	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 7/49 5/50 17/50 12/50 ALVEOLAR/BRONCHIOLAR ADENOMA OR CARCINOMA 12/49 12/50 22/50 17/50	Neoplastic Lesions