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The DNTP Technical Report (TR) Level of Evidence Criteria are available here: https://ntp.niehs.nih.gov/go/baresults. In the table below this information is further delineated into three fields:

  • Level of Evidence: The overall category of evidence of carcinogenic activity for the TR, Species, Strain and Sex
  • Organ Site Call: The level of evidence supported by the specific organ site for the TR, Species, Strain and Sex. When the Organ Site Call directly supports the TR Level Of Evidence the Finding Type flag is set to “Neoplastic Lesion”. Some Organ Site Calls could support a separate call of Equivocal Evidence; this is noted in Finding Type by the flag “May Have Been Related”
  • Finding Type: Further identification of the Organ Site Call. Where this says “Neoplastic Lesion” the Organ Site Call supports the TR Level of Evidence and the Organ Site Call is the same as that of the TR. Where Finding Type says “May Have Been Related” the TR Level of Evidence for other responses led to an overall call of Clear or Some Evidence but the specified organ supports a call of Equivocal Evidence.
View results
  • Organ: Intestines (Large)
  • Level of Evidence: Positive, Clear Evidence, Some Evidence
Displays results that match exactly with the given criteria.
Exact Match Publication No. CASRN Test Article Name Species Strain Sex Route Organ Level of Evidence Organ Site Call Tumor Type/Incidence Finding Type
Yes TR-047 139-65-1 4,4'-Thiodianiline Rats F344/N Male Dosed-Feed Intestines (Large) Positive Positive ADENOCARCINOMA Neoplastic Lesions
Yes TR-099 136-40-3 Phenazopyridine hydrochloride Rats F344/N Female Dosed-Feed Intestines (Large) Positive Positive (ADENOCARCINOMA) Neoplastic Lesions
Yes TR-099 136-40-3 Phenazopyridine hydrochloride Rats F344/N Male Dosed-Feed Intestines (Large) Positive Positive (ADENOCARCINOMA) Neoplastic Lesions
Yes TR-295 12001-29-5 Asbestos, chrysotile(IR) Rats F344/N Male Dosed-Feed Intestines (Large) Some Evidence Some Evidence ADENOMATOUS POLYP 0/85 9/250 2/100 Neoplastic Lesions
Yes TR-400 96-13-9 2,3-Dibromo-1-propanol Rats F344/N Female Topical Application Intestines (Large) Clear Evidence Clear Evidence ADENOCARCINOMA 0/50 3/50 4/49; ADENOMATOUS POLYP 0/50 12/50 37/50 Neoplastic Lesions
Yes TR-350 75-25-2 Tribromomethane Rats F344/N Female Gavage Intestines (Large) Clear Evidence Clear Evidence ADENOMATOUS POLYP 0/48 1/50 6/49 OR ADENOCARCINOMA 0/48 0/50 2/49 COMBINED 0/48 1/50 8/49 Neoplastic Lesions
Yes TR-350 75-25-2 Tribromomethane Rats F344/N Male Gavage Intestines (Large) Some Evidence Some Evidence ADENOMATOUS POLYP 0/50 0/50 2/50 OR ADENOCARCINOMA 0/50 0/50 1/50 COMBINED 0/50 0/50 3/50 Neoplastic Lesions
Yes TR-400 96-13-9 2,3-Dibromo-1-propanol Rats F344/N Male Topical Application Intestines (Large) Clear Evidence Clear Evidence ADENOCARCINOMA 0/50 8/50 11/50; ADENOMATOUS POLYP 1/50 13/50 29/50 Neoplastic Lesions
Yes TR-416 91-23-6 o-Nitroanisole Rats F344/N Female Dosed-Feed Intestines (Large) Clear Evidence Clear Evidence (STOP STUDY) ADENOMATOUS POLYP 0/60 8/60 18/60, CARCINOMA 0/60 0/60 2/60 Neoplastic Lesions
Yes TR-405 6459-94-5 C.I. Acid Red 114 Rats F344/N Female Dosed-Water Intestines (Large) Clear Evidence Clear Evidence NEOPLASMS 0/50 1/35 0/65 3/50 Neoplastic Lesions
Yes TR-390 612-82-8 3,3'-Dimethylbenzidine dihydrochloride Rats F344/N Female Dosed-Water Intestines (Large) Clear Evidence Clear Evidence ADENOMATOUS POLYP 0/60 2/45 7/75 4/60 OR ADENOCARCINOMA 0/60 0/45 3/75 6/60 COMBINED 0/60 2/45 10/75 9/60 Neoplastic Lesions
Yes TR-416 91-23-6 o-Nitroanisole Rats F344/N Male Dosed-Feed Intestines (Large) Clear Evidence Clear Evidence (STOP STUDY) ADENOMATOUS POLYP 0/60 26/60 30/60, CARCINOMA 0/60 0/60 5/60 Neoplastic Lesions
Yes TR-384 96-18-4 1,2,3-Trichloropropane Rats F344/N Male Gavage Intestines (Large) Clear Evidence Equivocal Evidence ADENOCARCINOMA 0/50 0/50 2/48 1/52 May Have Been Related
Yes TR-397 2429-74-5 C.I. Direct Blue 15 Rats F344/N Female Dosed-Water Intestines (Large) Clear Evidence Clear Evidence ADENOMATOUS POLYP 0/50 0/35 3/65 1/50 Neoplastic Lesions
Yes TR-384 96-18-4 1,2,3-Trichloropropane Rats F344/N Female Gavage Intestines (Large) Clear Evidence Equivocal Evidence ADENOCARCINOMA 0/49 0/47 1/52 2/52 May Have Been Related
Yes TR-390 612-82-8 3,3'-Dimethylbenzidine dihydrochloride Rats F344/N Male Dosed-Water Intestines (Large) Clear Evidence Clear Evidence ADENOMATOUS POLYP 0/60 0/45 7/75 10/60 OR ADENOCARCINOMA 0/60 0/45 3/75 15/60 COMBINED 0/60 0/45 10/75 23/75 Neoplastic Lesions
Yes TR-372 20325-40-0 3,3'-Dimethoxybenzidine dihydrochloride Rats F344/N Female Dosed-Water Intestines (Large) Clear Evidence Clear Evidence ADENOMATOUS POLYP 0/60 0/45 1/75 2/60 OR ADENOCARCINOMA 0/60 1/45 0/75 1/60 COMBINED 0/60 1/45 1/75 3/60 Neoplastic Lesions
Yes TR-397 2429-74-5 C.I. Direct Blue 15 Rats F344/N Male Dosed-Water Intestines (Large) Clear Evidence Clear Evidence NEOPLASMS 0/50 1/35 6/65 8/50 Neoplastic Lesions
Yes TR-321 75-27-4 Bromodichloromethane Rats F344/N Female Gavage Intestines (Large) Clear Evidence Clear Evidence ADENOMATOUS POLYP 0/46 0/50 7/47; ADENOCARCINOMA 0/46 0/50 6/47 Neoplastic Lesions
Yes TR-321 75-27-4 Bromodichloromethane Rats F344/N Male Gavage Intestines (Large) Clear Evidence Clear Evidence ADENOMATOUS POLYP 0/50 3/50 33/50; ADENOCARCINOMA 0/50 11/50 38/50 Neoplastic Lesions
Yes TR-383 81-49-2 1-Amino-2,4-dibromoanthraquinone Rats F344/N Female Dosed-Feed Intestines (Large) Clear Evidence Clear Evidence ADENOMATOUS POLYP (ADENOMA) 0/50 28/40 53/60 43/49; CARCINOMA 0/50 2/40 21/60 8/49 Neoplastic Lesions
Yes TR-372 20325-40-0 3,3'-Dimethoxybenzidine dihydrochloride Rats F344/N Male Dosed-Water Intestines (Large) Clear Evidence Clear Evidence ADENOMATOUS POLYP 0/60 1/45 4/75 5/60 OR ADENOCARCINOMA 0/60 4/45 11/75 8/60 COMBINED 0/60 4/45 14/75 13/60 Neoplastic Lesions
Yes TR-383 81-49-2 1-Amino-2,4-dibromoanthraquinone Rats F344/N Male Dosed-Feed Intestines (Large) Clear Evidence Clear Evidence ADENOMATOUS POLYP (ADENOMA) 0/50 13/40 51/59 40/50; CARCINOMA 0/50 1/40 11/59 17/50 Neoplastic Lesions
Yes TR-504 88-72-2 o-Nitrotoluene Mice B6C3F1 Male Dosed-Feed Intestines (Large) Clear Evidence Clear Evidence (CECUM) CARCINOMA 0/60 12/60 9/60 0/60 Neoplastic Lesions
Yes TR-504 88-72-2 o-Nitrotoluene Mice B6C3F1 Female Dosed-Feed Intestines (Large) Clear Evidence Clear Evidence (CECUM) CARCINOMA 0/60 1/60 4/60 3/60 Neoplastic Lesions
Yes TR-452 3296-90-0 2,2-bis(Bromomethyl)-1,3-propanediol Rats F344/N Male Dosed-Feed Intestines (Large) Clear Evidence Clear Evidence ADENOMA OR CARCINOMA 0/51 0/53 3/51 4/55 11/59 Neoplastic Lesions
Yes TR-499 22398-80-7 Indium phosphide Mice B6C3F1 Male Inhalation Intestines (Large) Clear Evidence Equivocal Evidence CARCINOMA 0/50 1/50 5/50 3/50; ADEMONA OR CARCINOMA 1/50 2/50 6/50 3/50 May Have Been Related
Yes TR-577 ALOEVLEAFEXT Aloe vera whole leaf extract (native) Rats F344 (NCTR) Female Dosed-Water Intestines (Large) Clear Evidence Clear Evidence Proximal colon adenoma 0/43 0/45 4/42 5/39; proximal colon carcinoma 0/43 0/45 2/42 4/39; cecum adenoma 0/47 0/48 1/47 6/48; ascending colon adenoma 0/47 0/48 1/46 5/46; all sections, adenoma 0/48, 0/48 6/48 13/48; carcinoma 0/48 0/48 3/48 4/48; adenoma and carcinoma combined 0/48 0/48 8/48 15/48 Neoplastic Lesions
Yes TR-577 ALOEVLEAFEXT Aloe vera whole leaf extract (native) Rats F344 (NCTR) Male Dosed-Water Intestines (Large) Clear Evidence Clear Evidence Proximal colon adenoma 0/44 0/44 7/46 10/41; proximal colon carcinoma 0/44 0/44 4/46 4/41; cecum adenoma 0/46 0/45 8/48 8/48; cecum carcinoma 0/46 0/45 1/48 2/48; ascending colon adenoma 0/47 0/47 19/48 8/46; ascending colon carcinoma 0/47 0/47 4/48 8/46; transverse colon adenoma 0/47 0/47 6/47 3/47; transverse colon carcinoma 0/47 0/47 1/47 1/47; adenoma 0/47, 0/48 26/48 23/48; carcinoma 0/47 0/48 10/48 14/48; all sections, adenoma and carcinoma combined 0/47 0/48 28/48 31/48 Neoplastic Lesions
Yes TR-564 106-94-5 1-Bromopropane Rats F344/N Female Inhalation Intestines (Large) Clear Evidence Clear Evidence Adenoma 0/50 1/50 2/50 5/50 Neoplastic Lesions
Yes TR-564 106-94-5 1-Bromopropane Rats F344/N Male Inhalation Intestines (Large) Some Evidence Some Evidence Adenoma 0/50 0/50 2/50 1/50 Neoplastic Lesions
Yes TR-549 5589-96-8 Water disinfection byproducts (Bromochloroacetic acid) Rats F344/N Female Dosed-Water Intestines (Large) Clear Evidence Clear Evidence Adenoma 0/50 0/50 3/50 7/50 Neoplastic Lesions
Yes TR-549 5589-96-8 Water disinfection byproducts (Bromochloroacetic acid) Rats F344/N Male Dosed-Water Intestines (Large) Clear Evidence Clear Evidence Adenoma 0/50 2/50 0/50 4/50 Neoplastic Lesions
Yes TR-587 79-94-7 Tetrabromobisphenol A Mice B6C3F1/N Male Gavage Intestines (Large) Some Evidence Equivocal Evidence (cecum or colon) adenoma or carcinoma 0/50 0/50 3/50 May Have Been Related