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The DNTP Technical Report (TR) Level of Evidence Criteria are available here: https://ntp.niehs.nih.gov/go/baresults. In the table below this information is further delineated into three fields:

  • Level of Evidence: The overall category of evidence of carcinogenic activity for the TR, Species, Strain and Sex
  • Organ Site Call: The level of evidence supported by the specific organ site for the TR, Species, Strain and Sex. When the Organ Site Call directly supports the TR Level Of Evidence the Finding Type flag is set to “Neoplastic Lesion”. Some Organ Site Calls could support a separate call of Equivocal Evidence; this is noted in Finding Type by the flag “May Have Been Related”
  • Finding Type: Further identification of the Organ Site Call. Where this says “Neoplastic Lesion” the Organ Site Call supports the TR Level of Evidence and the Organ Site Call is the same as that of the TR. Where Finding Type says “May Have Been Related” the TR Level of Evidence for other responses led to an overall call of Clear or Some Evidence but the specified organ supports a call of Equivocal Evidence.
View results
  • Organ: Intestines (Small)
  • Level of Evidence: Positive, Clear Evidence, Some Evidence
Displays results that match exactly with the given criteria.
Exact Match Publication No. CASRN Test Article Name Species Strain Sex Route Organ Level of Evidence Organ Site Call Tumor Type/Incidence Finding Type
Yes TR-015 133-06-2 Captan Mice B6C3F1 Female Dosed-Feed Intestines (Small) Positive Positive (POLYPOID CARCINOMA) Neoplastic Lesions
Yes TR-015 133-06-2 Captan Mice B6C3F1 Male Dosed-Feed Intestines (Small) Positive Positive (POLYPOID CARCINOMA) Neoplastic Lesions
Yes TR-434 106-99-0 1,3-Butadiene Mice B6C3F1 Male Inhalation Intestines (Small) Clear Evidence Equivocal Evidence CARCINOMA 0/50 1/50 1/50 1/50 2/50 0/73 May Have Been Related
Yes TR-405 6459-94-5 C.I. Acid Red 114 Rats F344/N Female Dosed-Water Intestines (Small) Clear Evidence Clear Evidence NEOPLASMS 0/50 0/35 1/65 2/50 Neoplastic Lesions
Yes TR-397 2429-74-5 C.I. Direct Blue 15 Rats F344/N Female Dosed-Water Intestines (Small) Clear Evidence Clear Evidence ADENOCARCINOMA 0/50 0/35 1/65 3/50 Neoplastic Lesions
Yes TR-430 28407-37-6 C.I. Direct Blue 218 Mice B6C3F1 Male Dosed-Feed Intestines (Small) Clear Evidence Equivocal Evidence CARCINOMA 1/50 0/50 0/50 3/50 May Have Been Related
Yes TR-397 2429-74-5 C.I. Direct Blue 15 Rats F344/N Male Dosed-Water Intestines (Small) Clear Evidence Clear Evidence NEOPLASMS 0/50 1/35 0/65 2/50 Neoplastic Lesions
Yes TR-540 7220-79-3 Methylene blue trihydrate Mice B6C3F1 Male Gavage Intestines (Small) Some Evidence Some Evidence CARCINOMA 0/50 1/50 2/50 4/50 ADENOMA OR CARCINOMA 1/50 2/50 4/50 6/50 Neoplastic Lesions
Yes TR-452 3296-90-0 2,2-bis(Bromomethyl)-1,3-propanediol Rats F344/N Male Dosed-Feed Intestines (Small) Clear Evidence Clear Evidence ADENOMA OR CARCINOMA 0/51 0/53 0/51 2/53 5/59 Neoplastic Lesions
Yes TR-582 75-35-4 Vinylidene Chloride Mice B6C3F1/N Female Inhalation Intestines (Small) Clear Evidence Equivocal Evidence (Duodenum, Jejunum, or Ileum): carcinoma 1/50 1/50 1/50 3/50 May Have Been Related
Yes TR-546 7789-12-0 Sodium dichromate dihydrate (VI) Mice B6C3F1/N Female Dosed-Water Intestines (Small) Clear Evidence Clear Evidence Duodenum: adenoma (0/50, 0/50, 2/50, 13/50, 12/50); carcinoma (0/50, 0/50, 0/50, 1/50, 6/50); Jejunum: adenoma (0/50, 1/50, 0/50, 2/50, 5/50); Duodenum, Jejunum, or Ileum: adenoma (0/50, 1/50, 2/50, 15/50, 16/50), carcinoma (1/50, 0/50, 2/50, 3/50, 7/50), adenoma or carcinoma (1/50, 1/50, 4/50, 17/50, 22/50) Neoplastic Lesions
Yes TR-546 7789-12-0 Sodium dichromate dihydrate (VI) Mice B6C3F1/N Male Dosed-Water Intestines (Small) Clear Evidence Clear Evidence Duodenum: adenoma (1/50, 0/50, 1/50, 5/50, 15/50); Duodenum, Jejunum, or Ileum: adenoma (1/50, 1/50, 1/50, 5/50, 17/50), carcinoma (0/50, 2/50, 1/50, 3/50, 5/50), adenoma or carcinoma (1/50, 3/50, 2/50, 7/50, 20/50) Neoplastic Lesions