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The DNTP Technical Report (TR) Level of Evidence Criteria are available here: https://ntp.niehs.nih.gov/go/baresults. In the table below this information is further delineated into three fields:

Level of Evidence: The overall category of evidence of carcinogenic activity for the TR, Species, Strain and Sex
Organ Site Call: The level of evidence supported by the specific organ site for the TR, Species, Strain and Sex. When the Organ Site Call directly supports the TR Level Of Evidence the Finding Type flag is set to “Neoplastic Lesion”. Some Organ Site Calls could support a separate call of Equivocal Evidence; this is noted in Finding Type by the flag “May Have Been Related”
Finding Type: Further identification of the Organ Site Call. Where this says “Neoplastic Lesion” the Organ Site Call supports the TR Level of Evidence and the Organ Site Call is the same as that of the TR. Where Finding Type says “May Have Been Related” the TR Level of Evidence for other responses led to an overall call of Clear or Some Evidence but the specified organ supports a call of Equivocal Evidence.

Displays results that match exactly with the given criteria.
Exact Match	Publication No.	CASRN	Test Article Name	Species	Strain	Sex	Route	Organ	Level of Evidence	Organ Site Call	Tumor Type/Incidence	Finding Type
Yes	TR-047	139-65-1	4,4'-Thiodianiline	Rats	F344/N	Male	Dosed-Feed	Intestines (Large)	Positive	Positive	ADENOCARCINOMA	Neoplastic Lesions
Yes	TR-099	136-40-3	Phenazopyridine hydrochloride	Rats	F344/N	Female	Dosed-Feed	Intestines (Large)	Positive	Positive	(ADENOCARCINOMA)	Neoplastic Lesions
Yes	TR-099	136-40-3	Phenazopyridine hydrochloride	Rats	F344/N	Male	Dosed-Feed	Intestines (Large)	Positive	Positive	(ADENOCARCINOMA)	Neoplastic Lesions
Yes	TR-295	12001-29-5	Asbestos, chrysotile(IR)	Rats	F344/N	Male	Dosed-Feed	Intestines (Large)	Some Evidence	Some Evidence	ADENOMATOUS POLYP 0/85 9/250 2/100	Neoplastic Lesions
Yes	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Female	Topical Application	Intestines (Large)	Clear Evidence	Clear Evidence	ADENOCARCINOMA 0/50 3/50 4/49; ADENOMATOUS POLYP 0/50 12/50 37/50	Neoplastic Lesions
Yes	TR-350	75-25-2	Tribromomethane	Rats	F344/N	Female	Gavage	Intestines (Large)	Clear Evidence	Clear Evidence	ADENOMATOUS POLYP 0/48 1/50 6/49 OR ADENOCARCINOMA 0/48 0/50 2/49 COMBINED 0/48 1/50 8/49	Neoplastic Lesions
Yes	TR-350	75-25-2	Tribromomethane	Rats	F344/N	Male	Gavage	Intestines (Large)	Some Evidence	Some Evidence	ADENOMATOUS POLYP 0/50 0/50 2/50 OR ADENOCARCINOMA 0/50 0/50 1/50 COMBINED 0/50 0/50 3/50	Neoplastic Lesions
Yes	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Male	Topical Application	Intestines (Large)	Clear Evidence	Clear Evidence	ADENOCARCINOMA 0/50 8/50 11/50; ADENOMATOUS POLYP 1/50 13/50 29/50	Neoplastic Lesions
Yes	TR-416	91-23-6	o-Nitroanisole	Rats	F344/N	Female	Dosed-Feed	Intestines (Large)	Clear Evidence	Clear Evidence	(STOP STUDY) ADENOMATOUS POLYP 0/60 8/60 18/60, CARCINOMA 0/60 0/60 2/60	Neoplastic Lesions
Yes	TR-405	6459-94-5	C.I. Acid Red 114	Rats	F344/N	Female	Dosed-Water	Intestines (Large)	Clear Evidence	Clear Evidence	NEOPLASMS 0/50 1/35 0/65 3/50	Neoplastic Lesions
Yes	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Intestines (Large)	Clear Evidence	Clear Evidence	ADENOMATOUS POLYP 0/60 2/45 7/75 4/60 OR ADENOCARCINOMA 0/60 0/45 3/75 6/60 COMBINED 0/60 2/45 10/75 9/60	Neoplastic Lesions
Yes	TR-416	91-23-6	o-Nitroanisole	Rats	F344/N	Male	Dosed-Feed	Intestines (Large)	Clear Evidence	Clear Evidence	(STOP STUDY) ADENOMATOUS POLYP 0/60 26/60 30/60, CARCINOMA 0/60 0/60 5/60	Neoplastic Lesions
Yes	TR-384	96-18-4	1,2,3-Trichloropropane	Rats	F344/N	Male	Gavage	Intestines (Large)	Clear Evidence	Equivocal Evidence	ADENOCARCINOMA 0/50 0/50 2/48 1/52	May Have Been Related
Yes	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Female	Dosed-Water	Intestines (Large)	Clear Evidence	Clear Evidence	ADENOMATOUS POLYP 0/50 0/35 3/65 1/50	Neoplastic Lesions
Yes	TR-384	96-18-4	1,2,3-Trichloropropane	Rats	F344/N	Female	Gavage	Intestines (Large)	Clear Evidence	Equivocal Evidence	ADENOCARCINOMA 0/49 0/47 1/52 2/52	May Have Been Related
Yes	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Intestines (Large)	Clear Evidence	Clear Evidence	ADENOMATOUS POLYP 0/60 0/45 7/75 10/60 OR ADENOCARCINOMA 0/60 0/45 3/75 15/60 COMBINED 0/60 0/45 10/75 23/75	Neoplastic Lesions
Yes	TR-372	20325-40-0	3,3'-Dimethoxybenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Intestines (Large)	Clear Evidence	Clear Evidence	ADENOMATOUS POLYP 0/60 0/45 1/75 2/60 OR ADENOCARCINOMA 0/60 1/45 0/75 1/60 COMBINED 0/60 1/45 1/75 3/60	Neoplastic Lesions
Yes	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Male	Dosed-Water	Intestines (Large)	Clear Evidence	Clear Evidence	NEOPLASMS 0/50 1/35 6/65 8/50	Neoplastic Lesions
Yes	TR-321	75-27-4	Bromodichloromethane	Rats	F344/N	Female	Gavage	Intestines (Large)	Clear Evidence	Clear Evidence	ADENOMATOUS POLYP 0/46 0/50 7/47; ADENOCARCINOMA 0/46 0/50 6/47	Neoplastic Lesions
Yes	TR-321	75-27-4	Bromodichloromethane	Rats	F344/N	Male	Gavage	Intestines (Large)	Clear Evidence	Clear Evidence	ADENOMATOUS POLYP 0/50 3/50 33/50; ADENOCARCINOMA 0/50 11/50 38/50	Neoplastic Lesions
Yes	TR-383	81-49-2	1-Amino-2,4-dibromoanthraquinone	Rats	F344/N	Female	Dosed-Feed	Intestines (Large)	Clear Evidence	Clear Evidence	ADENOMATOUS POLYP (ADENOMA) 0/50 28/40 53/60 43/49; CARCINOMA 0/50 2/40 21/60 8/49	Neoplastic Lesions
Yes	TR-372	20325-40-0	3,3'-Dimethoxybenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Intestines (Large)	Clear Evidence	Clear Evidence	ADENOMATOUS POLYP 0/60 1/45 4/75 5/60 OR ADENOCARCINOMA 0/60 4/45 11/75 8/60 COMBINED 0/60 4/45 14/75 13/60	Neoplastic Lesions
Yes	TR-383	81-49-2	1-Amino-2,4-dibromoanthraquinone	Rats	F344/N	Male	Dosed-Feed	Intestines (Large)	Clear Evidence	Clear Evidence	ADENOMATOUS POLYP (ADENOMA) 0/50 13/40 51/59 40/50; CARCINOMA 0/50 1/40 11/59 17/50	Neoplastic Lesions
Yes	TR-504	88-72-2	o-Nitrotoluene	Mice	B6C3F1	Male	Dosed-Feed	Intestines (Large)	Clear Evidence	Clear Evidence	(CECUM) CARCINOMA 0/60 12/60 9/60 0/60	Neoplastic Lesions
Yes	TR-504	88-72-2	o-Nitrotoluene	Mice	B6C3F1	Female	Dosed-Feed	Intestines (Large)	Clear Evidence	Clear Evidence	(CECUM) CARCINOMA 0/60 1/60 4/60 3/60	Neoplastic Lesions
Yes	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Intestines (Large)	Clear Evidence	Clear Evidence	ADENOMA OR CARCINOMA 0/51 0/53 3/51 4/55 11/59	Neoplastic Lesions
Yes	TR-499	22398-80-7	Indium phosphide	Mice	B6C3F1	Male	Inhalation	Intestines (Large)	Clear Evidence	Equivocal Evidence	CARCINOMA 0/50 1/50 5/50 3/50; ADEMONA OR CARCINOMA 1/50 2/50 6/50 3/50	May Have Been Related
Yes	TR-577	ALOEVLEAFEXT	Aloe vera whole leaf extract (native)	Rats	F344 (NCTR)	Female	Dosed-Water	Intestines (Large)	Clear Evidence	Clear Evidence	Proximal colon adenoma 0/43 0/45 4/42 5/39; proximal colon carcinoma 0/43 0/45 2/42 4/39; cecum adenoma 0/47 0/48 1/47 6/48; ascending colon adenoma 0/47 0/48 1/46 5/46; all sections, adenoma 0/48, 0/48 6/48 13/48; carcinoma 0/48 0/48 3/48 4/48; adenoma and carcinoma combined 0/48 0/48 8/48 15/48	Neoplastic Lesions
Yes	TR-577	ALOEVLEAFEXT	Aloe vera whole leaf extract (native)	Rats	F344 (NCTR)	Male	Dosed-Water	Intestines (Large)	Clear Evidence	Clear Evidence	Proximal colon adenoma 0/44 0/44 7/46 10/41; proximal colon carcinoma 0/44 0/44 4/46 4/41; cecum adenoma 0/46 0/45 8/48 8/48; cecum carcinoma 0/46 0/45 1/48 2/48; ascending colon adenoma 0/47 0/47 19/48 8/46; ascending colon carcinoma 0/47 0/47 4/48 8/46; transverse colon adenoma 0/47 0/47 6/47 3/47; transverse colon carcinoma 0/47 0/47 1/47 1/47; adenoma 0/47, 0/48 26/48 23/48; carcinoma 0/47 0/48 10/48 14/48; all sections, adenoma and carcinoma combined 0/47 0/48 28/48 31/48	Neoplastic Lesions
Yes	TR-564	106-94-5	1-Bromopropane	Rats	F344/N	Female	Inhalation	Intestines (Large)	Clear Evidence	Clear Evidence	Adenoma 0/50 1/50 2/50 5/50	Neoplastic Lesions
Yes	TR-564	106-94-5	1-Bromopropane	Rats	F344/N	Male	Inhalation	Intestines (Large)	Some Evidence	Some Evidence	Adenoma 0/50 0/50 2/50 1/50	Neoplastic Lesions
Yes	TR-549	5589-96-8	Water disinfection byproducts (Bromochloroacetic acid)	Rats	F344/N	Female	Dosed-Water	Intestines (Large)	Clear Evidence	Clear Evidence	Adenoma 0/50 0/50 3/50 7/50	Neoplastic Lesions
Yes	TR-549	5589-96-8	Water disinfection byproducts (Bromochloroacetic acid)	Rats	F344/N	Male	Dosed-Water	Intestines (Large)	Clear Evidence	Clear Evidence	Adenoma 0/50 2/50 0/50 4/50	Neoplastic Lesions
Yes	TR-587	79-94-7	Tetrabromobisphenol A	Mice	B6C3F1/N	Male	Gavage	Intestines (Large)	Some Evidence	Equivocal Evidence	(cecum or colon) adenoma or carcinoma 0/50 0/50 3/50	May Have Been Related

Displays all results in TRs which have data that match the given criteria.
Exact Match	Publication No.	CASRN	Test Article Name	Species	Strain	Sex	Route	Organ	Level of Evidence	Organ Site Call	Tumor Type/Incidence	Finding Type
No	TR-383	81-49-2	1-Amino-2,4-dibromoanthraquinone	Mice	B6C3F1	Female	Dosed-Feed	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 2/50 16/50 27/50; SQUAMOUS CELL CARCINOMA 0/50 12/50 11/50	Neoplastic Lesions
No	TR-383	81-49-2	1-Amino-2,4-dibromoanthraquinone	Mice	B6C3F1	Male	Dosed-Feed	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 13/51 16/50; SQUAMOUS CELL CARCINOMA 0/50 12/51 13/50	Neoplastic Lesions
Yes	TR-383	81-49-2	1-Amino-2,4-dibromoanthraquinone	Rats	F344/N	Female	Dosed-Feed	Intestines (Large)	Clear Evidence	Clear Evidence	ADENOMATOUS POLYP (ADENOMA) 0/50 28/40 53/60 43/49; CARCINOMA 0/50 2/40 21/60 8/49	Neoplastic Lesions
Yes	TR-383	81-49-2	1-Amino-2,4-dibromoanthraquinone	Rats	F344/N	Male	Dosed-Feed	Intestines (Large)	Clear Evidence	Clear Evidence	ADENOMATOUS POLYP (ADENOMA) 0/50 13/40 51/59 40/50; CARCINOMA 0/50 1/40 11/59 17/50	Neoplastic Lesions
No	TR-383	81-49-2	1-Amino-2,4-dibromoanthraquinone	Rats	F344/N	Female	Dosed-Feed	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 3/40 16/60 16/48 OR CARCINOMA 0/50 0/40 0/60 2/48	Neoplastic Lesions
No	TR-383	81-49-2	1-Amino-2,4-dibromoanthraquinone	Rats	F344/N	Male	Dosed-Feed	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA 2/50 10/40 11/59 14/50 OR CARCINOMA 0/50 0/40 2/59 1/50	Neoplastic Lesions
No	TR-383	81-49-2	1-Amino-2,4-dibromoanthraquinone	Mice	B6C3F1	Female	Dosed-Feed	Liver	Clear Evidence	Clear Evidence	ADENOMA 6/50 45/50 49/50; CARCINOMA 0/50 23/50 27/50	Neoplastic Lesions
No	TR-383	81-49-2	1-Amino-2,4-dibromoanthraquinone	Mice	B6C3F1	Male	Dosed-Feed	Liver	Clear Evidence	Clear Evidence	ADENOMA 10/50 38/51 39/50; CARCINOMA 9/50 18/51 21/50	Neoplastic Lesions
No	TR-383	81-49-2	1-Amino-2,4-dibromoanthraquinone	Rats	F344/N	Female	Dosed-Feed	Liver	Clear Evidence	Clear Evidence	ADENOMA 0/50 28/40 47/60 29/48; CARCINOMA 0/50 12/40 57/60 45/48; HEPATOCHOLANGIOCARCINOMA 0/50 0/40 11/60 13/48	Neoplastic Lesions
No	TR-383	81-49-2	1-Amino-2,4-dibromoanthraquinone	Rats	F344/N	Male	Dosed-Feed	Liver	Clear Evidence	Clear Evidence	ADENOMA 1/50 20/40 40/59 34/50; CARCINOMA 1/50 12/40 55/59 46/50; HEPATOCHOLANGIOCARCINOMA 0/50 0/40 6/59 2/50	Neoplastic Lesions
No	TR-383	81-49-2	1-Amino-2,4-dibromoanthraquinone	Mice	B6C3F1	Female	Dosed-Feed	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 4/50 17/50 13/49	Neoplastic Lesions
No	TR-383	81-49-2	1-Amino-2,4-dibromoanthraquinone	Mice	B6C3F1	Male	Dosed-Feed	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 7/50 26/51 24/50	Neoplastic Lesions
No	TR-383	81-49-2	1-Amino-2,4-dibromoanthraquinone	Rats	F344/N	Female	Dosed-Feed	Urinary Bladder	Clear Evidence	Clear Evidence	TRANSITIONAL CELL PAPILLOMA 0/50 2/40 7/60 9/46; TRANSITIONAL CELL CARCINOMA 0/50 0/40 8/60 16/46	Neoplastic Lesions
No	TR-383	81-49-2	1-Amino-2,4-dibromoanthraquinone	Rats	F344/N	Male	Dosed-Feed	Urinary Bladder	Clear Evidence	Clear Evidence	TRANSITIONAL CELL PAPILLOMA 0/50 1/38 2/58 8/50; TRANSITIONAL CELL CARCINOMA 0/50 0/38 1/58 4/50	Neoplastic Lesions
Yes	TR-564	106-94-5	1-Bromopropane	Rats	F344/N	Female	Inhalation	Intestines (Large)	Clear Evidence	Clear Evidence	Adenoma 0/50 1/50 2/50 5/50	Neoplastic Lesions
Yes	TR-564	106-94-5	1-Bromopropane	Rats	F344/N	Male	Inhalation	Intestines (Large)	Some Evidence	Some Evidence	Adenoma 0/50 0/50 2/50 1/50	Neoplastic Lesions
No	TR-564	106-94-5	1-Bromopropane	Mice	B6C3F1/N	Female	Inhalation	Lung	Clear Evidence	Clear Evidence	Alveolar/bronchiolar adenoma 1/50 6/50 4/50 10/50 alveolar/bronchiolar carcinoma 0/50 7/50 5/50 4/50 alveolar/bronchiolar adenoma or carcinoma 1/50 9/50 8/50 14/50	Neoplastic Lesions
No	TR-564	106-94-5	1-Bromopropane	Rats	F344/N	Male	Inhalation	Mesothelium (Abdominal Cavity/Tunica Vaginalis)	Some Evidence	Equivocal Evidence	Malignant: 0/50 2/50 2/50 4/50	May Have Been Related
No	TR-564	106-94-5	1-Bromopropane	Rats	F344/N	Male	Inhalation	Pancreas Islet Cell	Some Evidence	Equivocal Evidence	Adenoma 0/50 5/50 4/50 5/50	May Have Been Related
No	TR-564	106-94-5	1-Bromopropane	Rats	F344/N	Female	Inhalation	Skin	Clear Evidence	Equivocal Evidence	Squamous cell papilloma, keratoacanthoma, basal cell adenoma or carcinoma 1/50 1/50 1/50 4/50	May Have Been Related
No	TR-564	106-94-5	1-Bromopropane	Rats	F344/N	Male	Inhalation	Skin	Some Evidence	Some Evidence	Keratoacanthoma 0/50 3/50 6/50 6/50 keratoacanthoma or squamous cell carcinoma 1/50 4/50 6/50 8/50 keratoacanthoma, basal cell adenoma or carcinoma or squamous cell carcinoma 1/50 7/50 9/50 10/50	Neoplastic Lesions
No	TR-384	96-18-4	1,2,3-Trichloropropane	Rats	F344/N	Female	Gavage	Clitoral Gland	Clear Evidence	Clear Evidence	ADENOMA 5/46 10/46 13/50 10/51 OR CARCINOMA 0/46 0/46 4/50 6/51 COMBINED 5/46 10/46 17/50 15/51	Neoplastic Lesions
No	TR-384	96-18-4	1,2,3-Trichloropropane	Mice	B6C3F1	Female	Gavage	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 23/50 18/51 29/55; SQUAMOUS CELL CARCINOMA 0/50 46/50 49/51 49/55	Neoplastic Lesions
No	TR-384	96-18-4	1,2,3-Trichloropropane	Mice	B6C3F1	Male	Gavage	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 3/52 28/51 22/54 33/56; SQUAMOUS CELL CARCINOMA 0/52 40/51 50/54 51/56	Neoplastic Lesions
No	TR-384	96-18-4	1,2,3-Trichloropropane	Rats	F344/N	Female	Gavage	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 13/49 32/51 17/52; SQUAMOUS CELL CARCINOMA 0/50 3/49 9/51 4/52	Neoplastic Lesions
No	TR-384	96-18-4	1,2,3-Trichloropropane	Rats	F344/N	Male	Gavage	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 29/50 33/49 38/52; SQUAMOUS CELL CARCINOMA 0/50 9/50 27/49 13/52	Neoplastic Lesions
No	TR-384	96-18-4	1,2,3-Trichloropropane	Mice	B6C3F1	Female	Gavage	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 2/50 6/50 7/51 10/55	Neoplastic Lesions
No	TR-384	96-18-4	1,2,3-Trichloropropane	Mice	B6C3F1	Male	Gavage	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 1/52 2/51 10/54 11/56	Neoplastic Lesions
Yes	TR-384	96-18-4	1,2,3-Trichloropropane	Rats	F344/N	Female	Gavage	Intestines (Large)	Clear Evidence	Equivocal Evidence	ADENOCARCINOMA 0/49 0/47 1/52 2/52	May Have Been Related
Yes	TR-384	96-18-4	1,2,3-Trichloropropane	Rats	F344/N	Male	Gavage	Intestines (Large)	Clear Evidence	Equivocal Evidence	ADENOCARCINOMA 0/50 0/50 2/48 1/52	May Have Been Related
No	TR-384	96-18-4	1,2,3-Trichloropropane	Rats	F344/N	Male	Gavage	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 2/50 20/49 21/52	Neoplastic Lesions
No	TR-384	96-18-4	1,2,3-Trichloropropane	Mice	B6C3F1	Female	Gavage	Liver	Clear Evidence	Clear Evidence	ADENOMA 6/50 9/50 8/51 31/55 OR CARCINOMA 1/50 3/50 0/51 2/55 COMBINED 7/50 11/50 8/51 31/55	Neoplastic Lesions
No	TR-384	96-18-4	1,2,3-Trichloropropane	Mice	B6C3F1	Male	Gavage	Liver	Clear Evidence	Clear Evidence	ADENOMA 11/52 18/51 21/54 29/56; CARCINOMA 13/52 24/51 24/54 31/56	Neoplastic Lesions
No	TR-384	96-18-4	1,2,3-Trichloropropane	Rats	F344/N	Female	Gavage	Mammary Gland	Clear Evidence	Clear Evidence	ADENOCARCINOMA 1/50 6/49 12/52 21/52	Neoplastic Lesions
No	TR-384	96-18-4	1,2,3-Trichloropropane	Mice	B6C3F1	Male	Gavage	Oral Cavity	Clear Evidence	Equivocal Evidence	SQUAMOUS CELL PAPILLOMA 0/52 0/51 0/54 2/56	May Have Been Related
No	TR-384	96-18-4	1,2,3-Trichloropropane	Mice	B6C3F1	Female	Gavage	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL CARCINOMA 0/50 0/50 1/51 5/55	Neoplastic Lesions
No	TR-384	96-18-4	1,2,3-Trichloropropane	Rats	F344/N	Female	Gavage	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 1/50 5/49 10/52 18/52 ; SQUAMOUS CELL CARCINOMA 0/50 1/49 21/52 21/52	Neoplastic Lesions
No	TR-384	96-18-4	1,2,3-Trichloropropane	Rats	F344/N	Male	Gavage	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 4/50 9/49 19/52; SQUAMOUS CELL CARCINOMA 1/50 0/50 11/49 25/52	Neoplastic Lesions
No	TR-384	96-18-4	1,2,3-Trichloropropane	Rats	F344/N	Male	Gavage	Pancreas Acinar Cell	Clear Evidence	Clear Evidence	ADENOMA 5/50 21/50 36/49 29/52	Neoplastic Lesions
No	TR-384	96-18-4	1,2,3-Trichloropropane	Rats	F344/N	Male	Gavage	Preputial Gland	Clear Evidence	Clear Evidence	ADENOMA 5/49 3/47 5/49 11/50 OR CARCINOMA 0/49 3/47 3/49 5/50 COMBINED 5/49 6/47 8/49 16/50	Neoplastic Lesions
No	TR-384	96-18-4	1,2,3-Trichloropropane	Mice	B6C3F1	Female	Gavage	Uterus/Cervix	Clear Evidence	Clear Evidence	ADENOMA 0/50 1/50 0/51 3/54; ADENOCARCINOMA 0/50 4/50 3/51 6/54; POLYP 0/50 2/50 1/51 6/54	Neoplastic Lesions
No	TR-384	96-18-4	1,2,3-Trichloropropane	Rats	F344/N	Female	Gavage	Zymbal Gland	Clear Evidence	Clear Evidence	CARCINOMA 0/60 1/59 0/60 4/60	Neoplastic Lesions
No	TR-384	96-18-4	1,2,3-Trichloropropane	Rats	F344/N	Male	Gavage	Zymbal Gland	Clear Evidence	Clear Evidence	CARCINOMA 0/60 0/60 0/59 3/60	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Female	Dosed-Feed	Esophagus	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 0/51 1/53 10/52	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Esophagus	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/51 0/53 1/51 5/55 0/60	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Female	Dosed-Feed	Forestomach	Clear Evidence	Equivocal Evidence	SQUAMOUS CELL PAPILLOMA 0/52 1/50 5/51 3/50	May Have Been Related
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Male	Dosed-Feed	Forestomach	Clear Evidence	Equivocal Evidence	SQUAMOUS CELL PAPILLOMA 0/50 3/51 2/50 2/49 OR SQUAMOUS CELL CARCINOMA 0/50 0/51 1/50 2/49 COMBINED 0/50 3/51 3/50 4/49	May Have Been Related
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/51 0/53 0/51 1/55 5/60	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Female	Dosed-Feed	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 2/52 6/50 8/51 15/50 OR CARCINOMA 1/52 6/50 5/51 7/50 COMBINED 3/52 12/50 13/51 19/50	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Male	Dosed-Feed	Harderian Gland	Clear Evidence	Clear Evidence	ADENOMA 3/50 6/51 12/50 18/49 OR CARCINOMA 1/50 1/51 4/50 4/49 COMBINED 4/50 7/51 16/50 22/49	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Hematopoietic System	Clear Evidence	Clear Evidence	MONONUCLEAR CELL LEUKEMIA 27/51 29/53 40/51 34/55 25/60	Neoplastic Lesions
Yes	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Intestines (Large)	Clear Evidence	Clear Evidence	ADENOMA OR CARCINOMA 0/51 0/53 3/51 4/55 11/59	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Intestines (Small)	Clear Evidence	Clear Evidence	ADENOMA OR CARCINOMA 0/51 0/53 0/51 2/53 5/59	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Kidney Tubular Cell	Clear Evidence	Equivocal Evidence	ADENOMA 0/51 0/53 1/51 3/55 1/59	May Have Been Related
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Male	Dosed-Feed	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 0/51 3/50 2/49	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Female	Dosed-Feed	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 3/52 3/50 9/51 17/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 2/52 2/50 6/51 5/50 COMBINED 5/52 5/50 15/51 19/50	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Male	Dosed-Feed	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 12/50 4/51 12/50 21/49 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 3/50 7/51 8/50 11/49 COMBINED 15/50 11/51 16/50 25/49	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 1/51 0/53 3/51 1/55 4/60 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/51 1/53 0/51 3/55 3/60 COMBINED 1/51 1/53 3/51 4/55 7/60	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Female	Dosed-Feed	Mammary Gland	Clear Evidence	Equivocal Evidence	CARCINOMA 0/52 0/50 1/51 2/50	May Have Been Related
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Female	Dosed-Feed	Mammary Gland	Clear Evidence	Clear Evidence	FIBROADENOMA 25/50 45/51 46/53 45/52	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Mammary Gland	Clear Evidence	Clear Evidence	FIBROADENOMA 0/51 4/53 6/51 6/55 5/60 OR ADENOMA 0/51 0/53 1/51 1/55 0/60 COMBINED 0/51 4/53 7/51 7/55 5/60	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Mesothelium (Abdominal Cavity/Tunica Vaginalis)	Clear Evidence	Clear Evidence	MESOTHELIOMA 0/51 3/53 8/51 9/55 26/60	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Female	Dosed-Feed	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 2/50 2/51 4/53 5/52 OR SQUAMOUS CELL CARCINOMA 0/50 1/51 1/53 1/52 COMBINED 2/50 3/51 5/53 6/52	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/51 4/53 8/51 10/55 12/60 OR SQUAMOUS CELL CARCINOMA 0/51 0/53 1/51 0/55 2/60 COMBINED 0/51 4/53 9/51 10/55 13/60	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Pancreas Acinar Cell	Clear Evidence	Equivocal Evidence	ADENOMA 1/51 2/53 4/51 3/53 3/59	May Have Been Related
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Seminal Vesicle	Clear Evidence	Clear Evidence	ADENOMA 0/51 0/53 0/51 0/55 1/59 OR CARCINOMA 0/51 0/53 0/51 0/55 1/59 COMBINED 0/51 0/53 0/51 0/55 2/59	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Skin	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 1/51 0/53 2/51 5/55 11/60 OR KERATOACANTHOMA 3/51 5/53 11/51 16/55 10/60 OR TRICHOEPITHELIOMA 0/51 0/53 0/51 1/55 1/60 OR BASAL CELL ADENOMA 0/51 1/53 0/51 3/55 6/60 OR BASAL CELL CARCINOMA 0/51 0/53 2/51 2/55 0/60 OR SQUAMOUS CELL CARCINOMA 0/51 0/53 0/51 0/55 1/60 COMBINED 4/51 6/53 14/51 24/55 21/60	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Female	Dosed-Feed	Subcutaneous Tissue	Clear Evidence	Clear Evidence	SARCOMA 0/52 1/50 4/51 11/50	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Subcutaneous Tissue	Clear Evidence	Clear Evidence	FIBROMA 2/51 8/53 11/51 15/55 7/60 OR FIBROSARCOMA 0/51 1/53 0/51 0/55 1/60 OR SARCOMA 0/51 0/53 2/51 3/55 2/60 COMBINED 2/51 9/53 13/51 16/55 10/60	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Female	Dosed-Feed	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 0/51 2/53 3/52 OR CARCINOMA 0/50 0/51 0/53 1/52 COMBINED 0/50 0/51 2/53 4/52	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Thyroid Gland Follicular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/51 1/53 2/51 2/55 7/59 OR CARCINOMA 0/51 1/53 4/51 1/55 2/59 COMBINED 0/51 2/53 6/51 3/55 9/59	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Urinary Bladder	Clear Evidence	Clear Evidence	TRANSITIONAL CELL PAPILLOMA 0/51 0/53 1/51 2/55 1/59 OR TRANSITIONAL CELL CARCINOMA 0/51 0/53 0/51 1/55 1/59 COMBINED 0/51 0/53 1/51 3/55 2/59	Neoplastic Lesions
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Mice	B6C3F1	Female	Dosed-Feed	Vascular System (Unspecified)	Clear Evidence	Equivocal Evidence	HEMANGIOMA AND HEMANGIOSARCOMA 1/52 2/50 0/51 5/50	May Have Been Related
No	TR-452	3296-90-0	2,2-bis(Bromomethyl)-1,3-propanediol	Rats	F344/N	Male	Dosed-Feed	Zymbal Gland	Clear Evidence	Clear Evidence	ADENOMA 0/51 0/53 1/51 3/55 2/60 OR CARCINOMA 2/51 1/53 3/51 2/55 15/60 COMBINED 2/51 1/53 4/51 5/55 15/60	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Female	Topical Application	Clitoral Gland	Clear Evidence	Clear Evidence	ADENOMA 0/50 1/50 3/50 OR ADENOCARCINOMA 0/50 0/50 3/50 COMBINED 0/50 1/50 6/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Female	Topical Application	Esophagus	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 9/50 38/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Male	Topical Application	Esophagus	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 19/50 33/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Mice	B6C3F1	Female	Topical Application	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 12/49 17/50 OR SQUAMOUS CELL CARCINOMA 0/50 7/47 6/50 COMBINED 0/50 18/49 19/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Mice	B6C3F1	Male	Topical Application	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 12/50 20/50 OR SQUAMOUS CELL CARCINOMA 0/50 2/50 1/49 COMBINED 0/50 14/50 21/49	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Female	Topical Application	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 1/50 3/50 23/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Male	Topical Application	Forestomach	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 1/50 17/50	Neoplastic Lesions
Yes	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Female	Topical Application	Intestines (Large)	Clear Evidence	Clear Evidence	ADENOCARCINOMA 0/50 3/50 4/49; ADENOMATOUS POLYP 0/50 12/50 37/50	Neoplastic Lesions
Yes	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Male	Topical Application	Intestines (Large)	Clear Evidence	Clear Evidence	ADENOCARCINOMA 0/50 8/50 11/50; ADENOMATOUS POLYP 1/50 13/50 29/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Female	Topical Application	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 1/50 4/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Male	Topical Application	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 0/50 4/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Mice	B6C3F1	Male	Topical Application	Liver	Clear Evidence	Clear Evidence	ADENOMA 1/50 2/50 9/50 OR CARCINOMA 0/50 0/50 3/50 COMBINED 1/50 2/50 11/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Female	Topical Application	Liver	Clear Evidence	Clear Evidence	NEOPLASTIC NODULES 0/50 10/50 11/50 OR CARCINOMA 0/50 2/50 6/50 COMBINED 0/50 11/50 14/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Male	Topical Application	Liver	Clear Evidence	Clear Evidence	NEOPLASTIC NODULES 0/49 3/50 2/50 OR CARCINOMA 0/49 1/50 3/50 COMBINED 0/49 4/50 5/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Mice	B6C3F1	Female	Topical Application	Lung	Clear Evidence	Equivocal Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 0/50 3/50 4/50 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 1/50 0/50 0/50 COMBINED 1/50 3/50 4/50	May Have Been Related
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Mice	B6C3F1	Male	Topical Application	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 1/50 1/50 6/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Female	Topical Application	Mammary Gland	Clear Evidence	Clear Evidence	ADENOCARCINOMA 0/50 0/50 5/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Male	Topical Application	Mesothelium (Abdominal Cavity/Tunica Vaginalis)	Clear Evidence	Clear Evidence	0/50 1/50 4/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Female	Topical Application	Nasal Cavity	Clear Evidence	Clear Evidence	ADENOMA 0/50 44/50 49/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Male	Topical Application	Nasal Cavity	Clear Evidence	Clear Evidence	ADENOMA 0/50 48/50 48/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Female	Topical Application	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 27/50 41/50 OR SQUAMOUS CELL CARCINOMA 0/50 15/50 27/50 COMBINED 0/50 39/50 49/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Male	Topical Application	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 40/50 33/50 OR SQUAMOUS CELL CARCINOMA 0/50 16/50 25/50 COMBINED 0/50 47/50 48/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Mice	B6C3F1	Female	Topical Application	Skin	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 1/50 5/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 1/50 COMBINED 0/50 1/50 6/50; SEBACEOUS GLAND ADENOMA 0/50 3/50 2/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Mice	B6C3F1	Male	Topical Application	Skin	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 3/50 9/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 2/50 COMBINED 0/50 3/50 11/50; SEBACEOUS GLAND ADENOMA 0/50 1/50 8/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Female	Topical Application	Skin	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 0/50 2/50 OR SQUAMOUS CELL CARCINOMA 0/50 0/50 1/50 COMBINED 0/50 0/50 3/50; BASAL CELL NEOPLASMS, SEBACEOUS GLAND ADENOMA OR KERATOACANTHOMA 0/50 3/50 18/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Male	Topical Application	Skin	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 1/50 3/50 0/50 OR SQUAMOUS CELL CARCINOMA 0/50 5/50 8/50 COMBINED 1/50 8/50 8/50; BASAL CELL NEOPLASMS, SEBACEOUS GLAND ADENOMA, OR KERATOACANTHOMA 0/50 20/50 31/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Male	Topical Application	Vascular System (Spleen)	Clear Evidence	Clear Evidence	HEMANGIOMA 0/50 0/50 3/50 OR HEMANGIOSARCOMA 0/50 0/50 1/50 COMBINED 0/50 0/50 4/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Female	Topical Application	Zymbal Gland	Clear Evidence	Clear Evidence	ADENOMA 0/50 7/50 3/50 OR ADENOCARCINOMA 1/50 2/50 19/50 COMBINED 1/50 9/50 22/50	Neoplastic Lesions
No	TR-400	96-13-9	2,3-Dibromo-1-propanol	Rats	F344/N	Male	Topical Application	Zymbal Gland	Clear Evidence	Clear Evidence	ADENOMA 0/50 1/50 7/50 OR ADENOCARCINOMA 0/50 8/50 29/50 COMBINED 0/50 9/50 35/50	Neoplastic Lesions
No	TR-372	20325-40-0	3,3'-Dimethoxybenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Brain	Clear Evidence	Equivocal Evidence	ASTROCYTOMA 0/60 2/44 3/75 1/60	May Have Been Related
No	TR-372	20325-40-0	3,3'-Dimethoxybenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Clitoral Gland	Clear Evidence	Clear Evidence	ADENOMA 5/58 15/44 13/74 16/55; CARCINOMA 2/58 17/44 41/74 30/55	Neoplastic Lesions
Yes	TR-372	20325-40-0	3,3'-Dimethoxybenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Intestines (Large)	Clear Evidence	Clear Evidence	ADENOMATOUS POLYP 0/60 0/45 1/75 2/60 OR ADENOCARCINOMA 0/60 1/45 0/75 1/60 COMBINED 0/60 1/45 1/75 3/60	Neoplastic Lesions
Yes	TR-372	20325-40-0	3,3'-Dimethoxybenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Intestines (Large)	Clear Evidence	Clear Evidence	ADENOMATOUS POLYP 0/60 1/45 4/75 5/60 OR ADENOCARCINOMA 0/60 4/45 11/75 8/60 COMBINED 0/60 4/45 14/75 13/60	Neoplastic Lesions
No	TR-372	20325-40-0	3,3'-Dimethoxybenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Liver	Clear Evidence	Clear Evidence	NEOPLASTIC NODULE 0/60 1/44 0/75 2/60 OR CARCINOMA 0/60 0/44 0/75 1/60 COMBINED 0/60 1/44 0/75 3/60	Neoplastic Lesions
No	TR-372	20325-40-0	3,3'-Dimethoxybenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Liver	Clear Evidence	Clear Evidence	NEOPLASTIC NODULE 0/60 3/45 7/74 6/60; NEOPLASTIC NODULE OR CARCINOMA 1/60 1/45 0/74 2/60 COMBINED 1/60 4/45 7/74 8/60	Neoplastic Lesions
No	TR-372	20325-40-0	3,3'-Dimethoxybenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Mammary Gland	Clear Evidence	Clear Evidence	ADENOCARCINOMA 1/60 2/45 14/75 20/60	Neoplastic Lesions
No	TR-372	20325-40-0	3,3'-Dimethoxybenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Mesothelium (Abdominal Cavity/Tunica Vaginalis)	Clear Evidence	Clear Evidence	MESOTHELIOMA 2/60 1/45 7/75 6/60	Neoplastic Lesions
No	TR-372	20325-40-0	3,3'-Dimethoxybenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 2/60 2/45 3/75 3/60 OR SQUAMOUS CELL CARCINOMA 0/60 0/45 3/75 2/60 COMBINED 2/60 2/45 6/75 5/60	Neoplastic Lesions
No	TR-372	20325-40-0	3,3'-Dimethoxybenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 1/60 7/45 10/75 9/60; SQUAMOUS CELL PAPILLOMA OR SQUAMOUS CELL CARCINOMA 0/60 1/45 0/75 2/60 COMBINED 1/60 8/45 10/75 11/60	Neoplastic Lesions
No	TR-372	20325-40-0	3,3'-Dimethoxybenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Preputial Gland	Clear Evidence	Clear Evidence	ADENOMA 14/60 6/43 19/73 12/59 OR CARCINOMA 2/60 6/43 15/73 19/59 COMBINED 16/60 12/43 33/73 29/59	Neoplastic Lesions
No	TR-372	20325-40-0	3,3'-Dimethoxybenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Skin	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/60 0/45 3/75 0/60; BASAL CELL NEOPLASMS 0/60 4/45 3/75 2/60	Neoplastic Lesions
No	TR-372	20325-40-0	3,3'-Dimethoxybenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Skin	Clear Evidence	Clear Evidence	BASAL CELL OR SEBACEOUS GLAND NEOPLASMS 2/60 33/45 56/75 41/60; SQUAMOUS CELL NEOPLASMS 0/60 13/45 28/75 22/60	Neoplastic Lesions
No	TR-372	20325-40-0	3,3'-Dimethoxybenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Uterus/Cervix	Clear Evidence	Clear Evidence	ADENOMA 0/60 3/45 1/75 2/59 OR CARCINOMA 0/60 1/45 1/75 0/59 COMBINED 0/60 4/45 2/75 2/59	Neoplastic Lesions
No	TR-372	20325-40-0	3,3'-Dimethoxybenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Zymbal Gland	Clear Evidence	Clear Evidence	ADENOMA 0/60 3/45 4/75 3/60 OR CARCINOMA 1/60 10/45 17/75 13/60 COMBINED 1/60 12/45 21/75 16/60	Neoplastic Lesions
No	TR-372	20325-40-0	3,3'-Dimethoxybenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Zymbal Gland	Clear Evidence	Clear Evidence	ADENOMA 0/59 4/45 11/75 9/60; CARCINOMA 0/59 7/45 14/75 21/60	Neoplastic Lesions
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Brain	Clear Evidence	Equivocal Evidence	ASTROCYTOMA 0/60 1/45 1/75 0/60; GLIOMA 0/60 0/45 1/75 1/60; MENINGIOMA 0/60 1/45 0/75 0/60	May Have Been Related
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Brain	Clear Evidence	Equivocal Evidence	GLIOMA 0/60 0/45 1/75 1/60; MENINGIOMA 0/60 0/45 0/75 1/60; MENINGEAL SARCOMA 0/60 0/45 1/75 0/60	May Have Been Related
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Clitoral Gland	Clear Evidence	Clear Evidence	ADENOMA 0/60 9/45 32/75 17/59 OR CARCINOMA 0/60 5/45 11/75 18/59 COMBINED 0/60 14/45 42/75 32/59	Neoplastic Lesions
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Hematopoietic System	Clear Evidence	Equivocal Evidence	MONONUCLEAR CELL LEUKEMIA 1/60 3/45 6/75 4/60	May Have Been Related
Yes	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Intestines (Large)	Clear Evidence	Clear Evidence	ADENOMATOUS POLYP 0/60 2/45 7/75 4/60 OR ADENOCARCINOMA 0/60 0/45 3/75 6/60 COMBINED 0/60 2/45 10/75 9/60	Neoplastic Lesions
Yes	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Intestines (Large)	Clear Evidence	Clear Evidence	ADENOMATOUS POLYP 0/60 0/45 7/75 10/60 OR ADENOCARCINOMA 0/60 0/45 3/75 15/60 COMBINED 0/60 0/45 10/75 23/75	Neoplastic Lesions
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Liver	Clear Evidence	Clear Evidence	NEOPLASTIC NODULE 0/60 0/45 7/74 3/60 OR CARCINOMA 0/60 0/45 1/74 1/60 COMBINED 0/60 0/45 7/74 4/60	Neoplastic Lesions
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Liver	Clear Evidence	Clear Evidence	NEOPLASTIC NODULE 0/60 0/45 29/75 26/60 OR CARCINOMA 0/60 0/45 12/75 12/60 COMBINED 0/60 0/45 35/75 33/60	Neoplastic Lesions
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 1/60 1/45 3/74 3/60 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/60 0/45 0/74 1/60 COMBINED 1/60 1/45 3/74 4/60	Neoplastic Lesions
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 1/60 0/45 7/75 6/60 OR ALVEOLAR/BRONCHIOLAR CARCINOMA 0/60 0/45 1/75 0/60 COMBINED 1/60 0/45 8/75 6/60	Neoplastic Lesions
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Mammary Gland	Clear Evidence	Clear Evidence	ADENOCARCINOMA 0/60 1/45 3/75 6/60	Neoplastic Lesions
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Mesothelium (Abdominal Cavity/Tunica Vaginalis)	Clear Evidence	Clear Evidence	MESOTHELIOMA 0/60 0/45 3/75 4/60	Neoplastic Lesions
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/60 3/45 7/75 9/60 OR SQUAMOUS CELL CARCINOMA 0/60 1/45 2/75 4/60 COMBINED 0/60 3/45 9/75 13/60	Neoplastic Lesions
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/60 0/45 3/75 2/60 OR SQUAMOUS CELL CARCINOMA 0/60 0/45 1/75 3/60 COMBINED 0/60 0/45 4/75 5/60	Neoplastic Lesions
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Preputial Gland	Clear Evidence	Clear Evidence	ADENOMA 2/60 4/45 4/75 8/60 OR CARCINOMA 0/60 0/45 2/75 1/60 COMBINED 2/60 4/45 6/75 9/60	Neoplastic Lesions
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Skin	Clear Evidence	Clear Evidence	BASAL CELL ADENOMA 0/60 3/45 5/75 5/60 OR BASAL CELL CARCINOMA 0/60 0/45 5/75 4/60 COMBINED 0/60 3/45 10/75 9/60; SQUAMOUS CELL PAPILLOMA 0/60 1/45 6/75 5/60 OR SQUAMOUS CELL CARCINOMA 0/60 2/45 4/75 7/60 COMBINED 0/60 3/45 9/75 12/60	Neoplastic Lesions
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Skin	Clear Evidence	Clear Evidence	BASAL CELL ADENOMA 0/60 10/45 52/75 29/60 OR BASAL CELL CARCINOMA 0/60 1/45 4/75 2/60 COMBINED 0/60 11/45 54/75 30/60; SEBACEOUS GLAND ADENOMA 0/60 0/45 7/75 5/60; KERATOACANTHOMA 1/60 1/45 8/75 5/60; SQUAMOUS CELL PAPILLOMA 0/60 0/45 8/75 15/60 OR SQUAMOUS CELL CARCINOMA 0/60 2/45 10/75 13/60 COMBINED 0/60 2/45 17/75 27/60	Neoplastic Lesions
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Female	Dosed-Water	Zymbal Gland	Clear Evidence	Clear Evidence	ADENOMA 0/60 4/45 11/75 12/60 OR CARCINOMA 0/60 2/45 22/75 35/60 COMBINED 0/57 6/45 32/75 42/60	Neoplastic Lesions
No	TR-390	612-82-8	3,3'-Dimethylbenzidine dihydrochloride	Rats	F344/N	Male	Dosed-Water	Zymbal Gland	Clear Evidence	Clear Evidence	ADENOMA 1/60 1/45 13/75 16/60 OR CARCINOMA 0/60 2/45 21/75 23/60 COMBINED 1/60 3/45 32/75 36/60	Neoplastic Lesions
Yes	TR-047	139-65-1	4,4'-Thiodianiline	Rats	F344/N	Male	Dosed-Feed	Intestines (Large)	Positive	Positive	ADENOCARCINOMA	Neoplastic Lesions
No	TR-047	139-65-1	4,4'-Thiodianiline	Mice	B6C3F1	Female	Dosed-Feed	Liver	Positive	Positive	CARCINOMA	Neoplastic Lesions
No	TR-047	139-65-1	4,4'-Thiodianiline	Mice	B6C3F1	Male	Dosed-Feed	Liver	Positive	Positive	CARCINOMA	Neoplastic Lesions
No	TR-047	139-65-1	4,4'-Thiodianiline	Rats	F344/N	Male	Dosed-Feed	Liver	Positive	Positive	CARCINOMA	Neoplastic Lesions
No	TR-047	139-65-1	4,4'-Thiodianiline	Mice	B6C3F1	Female	Dosed-Feed	Thyroid Gland Follicular Cell	Positive	Positive	ADENOMA, CARCINOMA, ADENOMA OR CARCINOMA	Neoplastic Lesions
No	TR-047	139-65-1	4,4'-Thiodianiline	Mice	B6C3F1	Male	Dosed-Feed	Thyroid Gland Follicular Cell	Positive	Positive	CARCINOMA	Neoplastic Lesions
No	TR-047	139-65-1	4,4'-Thiodianiline	Rats	F344/N	Female	Dosed-Feed	Thyroid Gland Follicular Cell	Positive	Positive	CARCINOMA	Neoplastic Lesions
No	TR-047	139-65-1	4,4'-Thiodianiline	Rats	F344/N	Male	Dosed-Feed	Thyroid Gland Follicular Cell	Positive	Positive	CARCINOMA	Neoplastic Lesions
No	TR-047	139-65-1	4,4'-Thiodianiline	Rats	F344/N	Female	Dosed-Feed	Uterus/Cervix	Positive	Positive	ADENOCARCINOMA	Neoplastic Lesions
No	TR-047	139-65-1	4,4'-Thiodianiline	Rats	F344/N	Female	Dosed-Feed	Zymbal Gland	Positive	Positive	SQUAMOUS CELL PAPILLOMA OR CARCINOMA	Neoplastic Lesions
No	TR-047	139-65-1	4,4'-Thiodianiline	Rats	F344/N	Male	Dosed-Feed	Zymbal Gland	Positive	Positive	SQUAMOUS CELL PAPILLOMA OR CARCINOMA	Neoplastic Lesions
Yes	TR-577	ALOEVLEAFEXT	Aloe vera whole leaf extract (native)	Rats	F344 (NCTR)	Female	Dosed-Water	Intestines (Large)	Clear Evidence	Clear Evidence	Proximal colon adenoma 0/43 0/45 4/42 5/39; proximal colon carcinoma 0/43 0/45 2/42 4/39; cecum adenoma 0/47 0/48 1/47 6/48; ascending colon adenoma 0/47 0/48 1/46 5/46; all sections, adenoma 0/48, 0/48 6/48 13/48; carcinoma 0/48 0/48 3/48 4/48; adenoma and carcinoma combined 0/48 0/48 8/48 15/48	Neoplastic Lesions
Yes	TR-577	ALOEVLEAFEXT	Aloe vera whole leaf extract (native)	Rats	F344 (NCTR)	Male	Dosed-Water	Intestines (Large)	Clear Evidence	Clear Evidence	Proximal colon adenoma 0/44 0/44 7/46 10/41; proximal colon carcinoma 0/44 0/44 4/46 4/41; cecum adenoma 0/46 0/45 8/48 8/48; cecum carcinoma 0/46 0/45 1/48 2/48; ascending colon adenoma 0/47 0/47 19/48 8/46; ascending colon carcinoma 0/47 0/47 4/48 8/46; transverse colon adenoma 0/47 0/47 6/47 3/47; transverse colon carcinoma 0/47 0/47 1/47 1/47; adenoma 0/47, 0/48 26/48 23/48; carcinoma 0/47 0/48 10/48 14/48; all sections, adenoma and carcinoma combined 0/47 0/48 28/48 31/48	Neoplastic Lesions
No	TR-295	12001-29-5	Asbestos, chrysotile(IR)	Rats	F344/N	Female	Dosed-Feed	Unspecified	No Evidence		Not applicable	Not applicable
Yes	TR-295	12001-29-5	Asbestos, chrysotile(IR)	Rats	F344/N	Male	Dosed-Feed	Intestines (Large)	Some Evidence	Some Evidence	ADENOMATOUS POLYP 0/85 9/250 2/100	Neoplastic Lesions
No	TR-295	12001-29-5	Asbestos, chrysotile(IR) + Dimethyl hydrazine	Rats	F344/N	Female	Dosed-Feed	Unspecified	Inadequate Study		Not applicable	Not applicable
No	TR-295	12001-29-5	Asbestos, chrysotile(IR) + Dimethyl hydrazine	Rats	F344/N	Male	Dosed-Feed	Unspecified	Inadequate Study		Not applicable	Not applicable
No	TR-295	12001-29-5	Asbestos, chrysotile(SR)	Rats	F344/N	Female	Dosed-Feed	Unspecified	No Evidence		Not applicable	Not applicable
No	TR-295	12001-29-5	Asbestos, chrysotile(SR)	Rats	F344/N	Male	Dosed-Feed	Unspecified	No Evidence		Not applicable	Not applicable
Yes	TR-321	75-27-4	Bromodichloromethane	Rats	F344/N	Female	Gavage	Intestines (Large)	Clear Evidence	Clear Evidence	ADENOMATOUS POLYP 0/46 0/50 7/47; ADENOCARCINOMA 0/46 0/50 6/47	Neoplastic Lesions
Yes	TR-321	75-27-4	Bromodichloromethane	Rats	F344/N	Male	Gavage	Intestines (Large)	Clear Evidence	Clear Evidence	ADENOMATOUS POLYP 0/50 3/50 33/50; ADENOCARCINOMA 0/50 11/50 38/50	Neoplastic Lesions
No	TR-321	75-27-4	Bromodichloromethane	Mice	B6C3F1	Male	Gavage	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA 1/49 2/50 6/50; ADENOCARCINOMA 0/49 0/50 4/50; COMBINED 1/49 2/50 9/50	Neoplastic Lesions
No	TR-321	75-27-4	Bromodichloromethane	Rats	F344/N	Female	Gavage	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 1/50 6/50; ADENOCARCINOMA 0/50 0/50 9/50; COMBINED 0/50 1/50 15/50	Neoplastic Lesions
No	TR-321	75-27-4	Bromodichloromethane	Rats	F344/N	Male	Gavage	Kidney Tubular Cell	Clear Evidence	Clear Evidence	ADENOMA 0/50 1/50 3/50; ADENOCARCINOMA 0/50 0/50 10/50; COMBINED 0/50, 1/50, 13/50	Neoplastic Lesions
No	TR-321	75-27-4	Bromodichloromethane	Mice	B6C3F1	Female	Gavage	Liver	Clear Evidence	Clear Evidence	ADENOMA 1/50 13/48 23/50; CARCINOMA 2/50 5/48 10/50	Neoplastic Lesions
No	TR-405	6459-94-5	C.I. Acid Red 114	Rats	F344/N	Female	Dosed-Water	Adrenal Gland Medulla	Clear Evidence	Equivocal Evidence	PHEOCHROMOCYTOMA 1/50 3/35 5/64 1/50	May Have Been Related
No	TR-405	6459-94-5	C.I. Acid Red 114	Rats	F344/N	Male	Dosed-Water	Adrenal Gland Medulla	Clear Evidence	Equivocal Evidence	PHEOCHROMOCYTOMA 16/50 11/35 24/63 19/49 OR MALIGNANT PHEOCHROMOCYTOMA 2/50 0/35 3/63 2/49 COMBINED 17/50 11/35 27/63 21/49	May Have Been Related
No	TR-405	6459-94-5	C.I. Acid Red 114	Rats	F344/N	Female	Dosed-Water	Clitoral Gland	Clear Evidence	Clear Evidence	ADENOMA 7/48 10/32 10/62 10/50, CARCINOMA 4/48 9/32 19/62 15/50, COMBINED 11/48 17/32 28/62 23/50	Neoplastic Lesions
No	TR-405	6459-94-5	C.I. Acid Red 114	Rats	F344/N	Female	Dosed-Water	Hematopoietic System	Clear Evidence	Equivocal Evidence	MONONUCLEAR CELL LEUKEMIA 12/50 13/35 18/65 5/50	May Have Been Related
Yes	TR-405	6459-94-5	C.I. Acid Red 114	Rats	F344/N	Female	Dosed-Water	Intestines (Large)	Clear Evidence	Clear Evidence	NEOPLASMS 0/50 1/35 0/65 3/50	Neoplastic Lesions
No	TR-405	6459-94-5	C.I. Acid Red 114	Rats	F344/N	Female	Dosed-Water	Intestines (Small)	Clear Evidence	Clear Evidence	NEOPLASMS 0/50 0/35 1/65 2/50	Neoplastic Lesions
No	TR-405	6459-94-5	C.I. Acid Red 114	Rats	F344/N	Female	Dosed-Water	Liver	Clear Evidence	Clear Evidence	NEOPLASTIC NODULE 0/50 0/35 15/64 6/50, CARCINOMA 0/50 0/35 6/64 3/50, COMBINED 0/50 0/35 19/64 8/50	Neoplastic Lesions
No	TR-405	6459-94-5	C.I. Acid Red 114	Rats	F344/N	Male	Dosed-Water	Liver	Clear Evidence	Clear Evidence	NEOPLASTIC NODULE 2/50 1/35 10/65 15/50, CARCINOMA 0/50 1/35 6/65 7/50, COMBINED 2/50 2/35 15/65 20/50	Neoplastic Lesions
No	TR-405	6459-94-5	C.I. Acid Red 114	Rats	F344/N	Male	Dosed-Water	Lung	Clear Evidence	Equivocal Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 0/50 2/35 1/65 3/50, ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 0/35 1/65 0/50, COMBINED 2/50 2/35 2/65 3/50	May Have Been Related
No	TR-405	6459-94-5	C.I. Acid Red 114	Rats	F344/N	Female	Dosed-Water	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 1/50 2/35 8/65 4/50, ALVEOLAR/BRONCHIOLAR CARCINOMA 0/50 0/35 1/65 0/50, COMBINED 1/50 2/35 9/65 4/50	Neoplastic Lesions
No	TR-405	6459-94-5	C.I. Acid Red 114	Rats	F344/N	Female	Dosed-Water	Mammary Gland	Clear Evidence	Equivocal Evidence	ADENOCARCINOMA 0/50 3/35 6/65 3/50	May Have Been Related
No	TR-405	6459-94-5	C.I. Acid Red 114	Rats	F344/N	Male	Dosed-Water	Oral Cavity	Clear Evidence	Equivocal Evidence	SQUAMOUS CELL PAPILLOMA 0/50 0/35 1/65 2/50	May Have Been Related
No	TR-405	6459-94-5	C.I. Acid Red 114	Rats	F344/N	Female	Dosed-Water	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 3/35 6/65 4/50, SQUAMOUS CELL CARCINOMA 0/50 0/35 3/65 2/50, COMBINED 0/50 3/35 9/65 6/50	Neoplastic Lesions
No	TR-405	6459-94-5	C.I. Acid Red 114	Rats	F344/N	Female	Dosed-Water	Skin	Clear Evidence	Clear Evidence	BASAL CELL ADENOMA 0/50 3/35 5/65 3/50, BASAL CELL CARCINOMA 0/50 1/35 2/65 2/50, COMBINED 0/50 4/35 7/65 5/50	Neoplastic Lesions
No	TR-405	6459-94-5	C.I. Acid Red 114	Rats	F344/N	Male	Dosed-Water	Skin	Clear Evidence	Clear Evidence	BASAL CELL ADENOMA 1/50 4/35 26/65 30/50, BASAL CELL CARCINOMA 0/50 1/35 5/65 6/50, COMBINED 1/50 5/35 28/65 32/50; KERATOACANTHOMA 1/50 1/35 4/65 7/50; SEBACEOUS GLAND ADENOMA 0/50 1/35 5/65 5/50, SEBACEOUS GLAND CARCINOMA 1/50 0/35 0/65 1/50, COMBINED 1/50 1/35 5/65 6/50; SQUAMOUS CELL PAPILLOMA 1/50 0/35 3/65 2/50, SQUAMOUS CELL CARCINOMA 0/50 2/35 8/65 7/50, COMBINED 1/50 2/35 11/65 9/50	Neoplastic Lesions
No	TR-405	6459-94-5	C.I. Acid Red 114	Rats	F344/N	Female	Dosed-Water	Zymbal Gland	Clear Evidence	Clear Evidence	ADENOMA 0/50 0/35 2/65 6/50, CARCINOMA 0/50 3/35 17/65 13/50, COMBINED 0/50 3/35 18/65 19/50	Neoplastic Lesions
No	TR-405	6459-94-5	C.I. Acid Red 114	Rats	F344/N	Male	Dosed-Water	Zymbal Gland	Clear Evidence	Clear Evidence	ADENOMA 0/50 0/35 1/65 1/50, CARCINOMA 0/50 0/35 7/65 6/50, COMBINED 0/50 0/35 8/65 7/50	Neoplastic Lesions
No	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Male	Dosed-Water	Brain	Clear Evidence	Equivocal Evidence	ASTROCYTOMA 0/50 1/35 1/65 2/50	May Have Been Related
No	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Female	Dosed-Water	Clitoral Gland	Clear Evidence	Clear Evidence	ADENOMA 5/50 5/31 12/64 12/50, CARCINOMA 2/50 6/31 12/64 15/50, COMBINED 7/50 11/31 24/64 27/50	Neoplastic Lesions
No	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Male	Dosed-Water	Hematopoietic System	Clear Evidence	Equivocal Evidence	MONONUCLEAR CELL LEUKEMIA 17/50 19/35 28/65 20/50	May Have Been Related
No	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Female	Dosed-Water	Hematopoietic System	Clear Evidence	Clear Evidence	MONONUCLEAR CELL LEUKEMIA 7/50 13/35 27/65 15/50	Neoplastic Lesions
Yes	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Female	Dosed-Water	Intestines (Large)	Clear Evidence	Clear Evidence	ADENOMATOUS POLYP 0/50 0/35 3/65 1/50	Neoplastic Lesions
Yes	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Male	Dosed-Water	Intestines (Large)	Clear Evidence	Clear Evidence	NEOPLASMS 0/50 1/35 6/65 8/50	Neoplastic Lesions
No	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Female	Dosed-Water	Intestines (Small)	Clear Evidence	Clear Evidence	ADENOCARCINOMA 0/50 0/35 1/65 3/50	Neoplastic Lesions
No	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Male	Dosed-Water	Intestines (Small)	Clear Evidence	Clear Evidence	NEOPLASMS 0/50 1/35 0/65 2/50	Neoplastic Lesions
No	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Female	Dosed-Water	Liver	Clear Evidence	Clear Evidence	NEOPLASTIC NODULE 0/50 0/35 2/65 4/50, CARCINOMA 0/50 0/35 0/65 1/50, COMBINED 0/50 0/35 2/65 5/50	Neoplastic Lesions
No	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Male	Dosed-Water	Liver	Clear Evidence	Clear Evidence	NEOPLASTIC NODULE 0/50 6/35 8/65 7/50, CARCINOMA 0/50 0/35 1/65 4/50, COMBINED 0/50 6/35 9/65 11/50	Neoplastic Lesions
No	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Female	Dosed-Water	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 2/50 3/35 12/65 9/50, SQUAMOUS CELL CARCINOMA 0/50 1/35 8/65 6/50, COMBINED 2/50 4/35 19/65 15/50	Neoplastic Lesions
No	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Male	Dosed-Water	Oral Cavity	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 9/35 18/65 15/50, SQUAMOUS CELL CARCINOMA 1/50 1/35 6/65 2/50, COMBINED 1/50 10/35 24/65 17/50	Neoplastic Lesions
No	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Male	Dosed-Water	Preputial Gland	Clear Evidence	Clear Evidence	ADENOMA 6/49 2/35 12/64 8/48, CARCINOMA 2/49 3/35 11/64 1/48, COMBINED 8/49 5/35 23/64 9/48	Neoplastic Lesions
No	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Female	Dosed-Water	Skin	Clear Evidence	Clear Evidence	SQUAMOUS CELL PAPILLOMA 0/50 2/35 5/65 5/50, SQUAMOUS CELL CARCINOMA 0/50 0/35 1/65 0/50, COMBINED 0/50 2/35 6/65 5/50	Neoplastic Lesions
No	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Male	Dosed-Water	Skin	Clear Evidence	Clear Evidence	BASAL CELL ADENOMA 2/50 8/35 23/65 26/50, BASAL CELL CARCINOMA 0/50 2/35 4/65 10/50, COMBINED 2/50 9/35 27/65 28/50; SEBACEOUS GLAND ADENOMA 0/50 1/35 7/65 3/50; SQUAMOUS CELL PAPILLOMA 2/50 3/35 5/65 8/50, SQUAMOUS CELL CARCINOMA 0/50 1/35 7/65 13/50, COMBINED 2/50 4/35 11/65 19/50	Neoplastic Lesions
No	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Female	Dosed-Water	Uterus/Cervix	Clear Evidence	Clear Evidence	ADENOMA 0/50 0/35 1/65 1/50, ADENOCARCINOMA 1/50 0/35 0/65 3/50, COMBINED 1/50 0/35 1/65 4/50	Neoplastic Lesions
No	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Female	Dosed-Water	Zymbal Gland	Clear Evidence	Clear Evidence	ADENOMA 0/50 1/35 5/65 3/50, CARCINOMA 0/50 4/35 7/65 14/50, COMBINED 0/50 4/35 11/65 17/50	Neoplastic Lesions
No	TR-397	2429-74-5	C.I. Direct Blue 15	Rats	F344/N	Male	Dosed-Water	Zymbal Gland	Clear Evidence	Clear Evidence	ADENOMA 0/50 2/35 2/65 4/50, CARCINOMA 1/50 3/35 8/65 17/50, COMBINED 1/50 5/35 10/65 20/50	Neoplastic Lesions
No	TR-499	22398-80-7	Indium phosphide	Rats	F344/N	Female	Inhalation	Adrenal Gland Medulla	Clear Evidence	Clear Evidence	BENIGN PHEOCHROMOCYTOMA 2/50 6/48 2/50 9/49	Neoplastic Lesions
No	TR-499	22398-80-7	Indium phosphide	Rats	F344/N	Male	Inhalation	Adrenal Gland Medulla	Clear Evidence	Clear Evidence	BENIGN PHEOCHROMOCYTOMA 10/50 22/50 16/49 23/50 BENIGN OR MALIGNANT PHEOCHROMOCYTOMA 10/50 26/50 18/49 24/50	Neoplastic Lesions
No	TR-499	22398-80-7	Indium phosphide	Rats	F344/N	Female	Inhalation	Hematopoietic System	Clear Evidence	Equivocal Evidence	MONONUCLEAR CELL LEUKEMIA 14/50 21/50 14/50 24/50	May Have Been Related
No	TR-499	22398-80-7	Indium phosphide	Rats	F344/N	Male	Inhalation	Hematopoietic System	Clear Evidence	Equivocal Evidence	MONONUCLEAR CELL LEUKEMIA 16/50 23/50 29/50 25/50	May Have Been Related
Yes	TR-499	22398-80-7	Indium phosphide	Mice	B6C3F1	Male	Inhalation	Intestines (Large)	Clear Evidence	Equivocal Evidence	CARCINOMA 0/50 1/50 5/50 3/50; ADEMONA OR CARCINOMA 1/50 2/50 6/50 3/50	May Have Been Related
No	TR-499	22398-80-7	Indium phosphide	Mice	B6C3F1	Female	Inhalation	Liver	Clear Evidence	Clear Evidence	ADENOMA 12/50 14/50 18/50 14/50; CARCINOMA 6/50 17/50 8/50 10/50; COMBINED 18/50 28/50 24/50 23/50	Neoplastic Lesions
No	TR-499	22398-80-7	Indium phosphide	Mice	B6C3F1	Male	Inhalation	Liver	Clear Evidence	Clear Evidence	ADENOMA 17/50 24/50 23/50 32/50; CARCINOMA 11/50 22/50 23/50 16/50; COMBINED 26/50 40/50 37/50 39/50	Neoplastic Lesions
No	TR-499	22398-80-7	Indium phosphide	Mice	B6C3F1	Female	Inhalation	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADEMONA 3/50 6/50 10/50 7/50; ALVEOLAR/BRONCHIOLAR CARCINOMA 1/50 6/50 5/50 7/50; COMBINED 4/50 11/50 15/50 14/50	Neoplastic Lesions
No	TR-499	22398-80-7	Indium phosphide	Mice	B6C3F1	Male	Inhalation	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR CARCINOMA 6/50 15/50 22/50 13/50	Neoplastic Lesions
No	TR-499	22398-80-7	Indium phosphide	Rats	F344/N	Female	Inhalation	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADEMONA 0/50 7/50 5/50 19/50; ALVEOLAR/BRONCHIOLAR CARCINOMA 1/50 3/50 1/50 11/50; COMBINED 1/50 10/50 6/50 26/50	Neoplastic Lesions
No	TR-499	22398-80-7	Indium phosphide	Rats	F344/N	Male	Inhalation	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADEMONA 6/50 13/50 27/50 30/50; ALVEOLAR/BRONCHIOLAR CARCINOMA 1/50 10/50 8/50 16/50; COMBINED 7/50 22/50 30/50 35/50; SQUAMOUS CELL CARCINOMA 0/50 0/50 0/50 4/50	Neoplastic Lesions
No	TR-499	22398-80-7	Indium phosphide	Rats	F344/N	Female	Inhalation	Mammary Gland	Clear Evidence	Equivocal Evidence	CARCINOMA 0/50 8/50 3/50 2/50	May Have Been Related
No	TR-499	22398-80-7	Indium phosphide	Rats	F344/N	Male	Inhalation	Skin	Clear Evidence	Equivocal Evidence	FIBROMA 1/50 4/50 7/50 3/50; FIBROMA OR FIBROSARCOMA 2/50 4/50 8/50 4/50	May Have Been Related
No	TR-416	91-23-6	o-Nitroanisole	Rats	F344/N	Female	Dosed-Feed	Forestomach	Clear Evidence	Equivocal Evidence	SQUAMOUS CELL PAPILLOMA 0/50 1/50 0/50 1/50	May Have Been Related
No	TR-416	91-23-6	o-Nitroanisole	Rats	F344/N	Male	Dosed-Feed	Forestomach	Clear Evidence	Equivocal Evidence	SQUAMOUS CELL PAPILLOMA O/50 0/50 1/50 1/50; SQUAMOUS CELL CARCINOMA 0/50 0/50 1/50 1/50	May Have Been Related
No	TR-416	91-23-6	o-Nitroanisole	Rats	F344/N	Female	Dosed-Feed	Hematopoietic System	Clear Evidence	Clear Evidence	MONONUCLEAR CELL LEUKEMIA 14/50 11/50 14/50 26/50	Neoplastic Lesions
No	TR-416	91-23-6	o-Nitroanisole	Rats	F344/N	Male	Dosed-Feed	Hematopoietic System	Clear Evidence	Clear Evidence	MONONUCLEAR CELL LEUKEMIA 26/50 25/50 42/50 34/50	Neoplastic Lesions
Yes	TR-416	91-23-6	o-Nitroanisole	Rats	F344/N	Female	Dosed-Feed	Intestines (Large)	Clear Evidence	Clear Evidence	(STOP STUDY) ADENOMATOUS POLYP 0/60 8/60 18/60, CARCINOMA 0/60 0/60 2/60	Neoplastic Lesions
Yes	TR-416	91-23-6	o-Nitroanisole	Rats	F344/N	Male	Dosed-Feed	Intestines (Large)	Clear Evidence	Clear Evidence	(STOP STUDY) ADENOMATOUS POLYP 0/60 26/60 30/60, CARCINOMA 0/60 0/60 5/60	Neoplastic Lesions
No	TR-416	91-23-6	o-Nitroanisole	Rats	F344/N	Female	Dosed-Feed	Kidney Transitional Cell	Clear Evidence	Clear Evidence	(STOP STUDY) PAPILLOMA 0/60 0/60 1/60 OR CARCINOMA 0/60 0/60 1/60	Neoplastic Lesions
No	TR-416	91-23-6	o-Nitroanisole	Rats	F344/N	Male	Dosed-Feed	Kidney Transitional Cell	Clear Evidence	Clear Evidence	PAPILLOMA (STOP STUDY) 0/60 0/60 4/60 OR CARCINOMA 0/60 1/60 8/60	Neoplastic Lesions
No	TR-416	91-23-6	o-Nitroanisole	Rats	F344/N	Male	Dosed-Feed	Kidney Tubular Cell	Clear Evidence	Equivocal Evidence	ADENOMA 0/49 1/50 1/50 1/49 OR CARCINOMA 0/49 0/50 0/50 2/49	May Have Been Related
No	TR-416	91-23-6	o-Nitroanisole	Mice	B6C3F1	Male	Dosed-Feed	Liver	Clear Evidence	Clear Evidence	ADENOMA 14/50 26/50 41/50 29/50; CARCINOMA 7/50 12/50 11/50 7/50; HEPATOBLASTOMA 0/50 3/50 17/50 9/50	Neoplastic Lesions
No	TR-416	91-23-6	o-Nitroanisole	Mice	B6C3F1	Female	Dosed-Feed	Liver	Some Evidence	Some Evidence	ADENOMA 14/50 2/50 36/50 18/50	Neoplastic Lesions
No	TR-416	91-23-6	o-Nitroanisole	Rats	F344/N	Female	Dosed-Feed	Urinary Bladder	Clear Evidence	Clear Evidence	(STOP STUDY) TRANSITIONAL CELL PAPILLOMA 0/58 2/59 1/60, TRANSITIONAL CELL CARCINOMA 0/58 28/59 48/60	Neoplastic Lesions
No	TR-416	91-23-6	o-Nitroanisole	Rats	F344/N	Male	Dosed-Feed	Urinary Bladder	Clear Evidence	Clear Evidence	(STOP STUDY) TRANSITIONAL CELL PAPILLOMA 0/59 9/59 1/60, TRANSITIONAL CELL CARCINOMA 0/59 27/59 50/60, SQUAMOUS CELL PAPILLOMA 0/59 0/59 4/60, SQUAMOUS CELL CARCINOMA 0/59 0/59 6/60, SARCOMA 0/59 2/59 9/60	Neoplastic Lesions
No	TR-504	88-72-2	o-Nitrotoluene	Mice	B6C3F1	Female	Dosed-Feed	Hematopoietic System	Clear Evidence	Clear Evidence	HEMANGIOSARCOMA 0/60 2/60 3/60 50/60	Neoplastic Lesions
No	TR-504	88-72-2	o-Nitrotoluene	Mice	B6C3F1	Male	Dosed-Feed	Hematopoietic System	Clear Evidence	Clear Evidence	HEMANGIOSARCOMA 4/60 17/60 55/60 60/60	Neoplastic Lesions
Yes	TR-504	88-72-2	o-Nitrotoluene	Mice	B6C3F1	Female	Dosed-Feed	Intestines (Large)	Clear Evidence	Clear Evidence	(CECUM) CARCINOMA 0/60 1/60 4/60 3/60	Neoplastic Lesions
Yes	TR-504	88-72-2	o-Nitrotoluene	Mice	B6C3F1	Male	Dosed-Feed	Intestines (Large)	Clear Evidence	Clear Evidence	(CECUM) CARCINOMA 0/60 12/60 9/60 0/60	Neoplastic Lesions
No	TR-504	88-72-2	o-Nitrotoluene	Rats	F344/N	Female	Dosed-Feed	Liver	Clear Evidence	Equivocal Evidence	ADENOMA 1/60 0/59 1/60 6/60	May Have Been Related
No	TR-504	88-72-2	o-Nitrotoluene	Mice	B6C3F1	Female	Dosed-Feed	Liver	Clear Evidence	Clear Evidence	ADENOMA 7/60 5/59 19/59 29/60 CARCINOMA 2/60 4/59 6/59 16/60 COMBINED 9/60 9/59 24/59 39/60	Neoplastic Lesions
No	TR-504	88-72-2	o-Nitrotoluene	Rats	F344/N	Male	Dosed-Feed	Liver	Clear Evidence	Clear Evidence	ADENOMA 2/60 3/60 3/60 7/60 3/60 4/60 ADENOMA OR CARCINOMA 3/60 3/60 3/60 8/60 3/60 6/60 CHOLANGIOCARCINOMA 0/60 0/60 0/60 0/60 0/60 3/60 HEPATOCHOLANGIOCARCINOMA 0/60 1/60 0/60 1/60 0/60 0/60	Neoplastic Lesions
No	TR-504	88-72-2	o-Nitrotoluene	Rats	F344/N	Male	Dosed-Feed	Lung	Clear Evidence	Clear Evidence	ALVEOLAR/BRONCHIOLAR ADENOMA 1/60 5/60 1/60 2/60 3/60 8/60 OR ALVEOLAR/BRONCHIOLAR ADENOMA OR CARCINOMA 2/60 5/60 1/60 2/60 3/60 11/60	Neoplastic Lesions
No	TR-504	88-72-2	o-Nitrotoluene	Rats	F344/N	Female	Dosed-Feed	Mammary Gland	Clear Evidence	Clear Evidence	FIBROADENOMA 23/60 47/60 52/60 56/60	Neoplastic Lesions
No	TR-504	88-72-2	o-Nitrotoluene	Rats	F344/N	Male	Dosed-Feed	Mammary Gland	Clear Evidence	Clear Evidence	FIBROADENOMA 0/60 7/60 10/60 2/60 13/60 20/60	Neoplastic Lesions
No	TR-504	88-72-2	o-Nitrotoluene	Rats	F344/N	Male	Dosed-Feed	Mesothelium (Abdominal Cavity/Tunica Vaginalis)	Clear Evidence	Clear Evidence	MALIGNANT MESOTHELIOMA 2/60 20/60 29/60 44/60 44/60 54/60	Neoplastic Lesions
No	TR-504	88-72-2	o-Nitrotoluene	Rats	F344/N	Female	Dosed-Feed	Skin	Clear Evidence	Clear Evidence	(SUBCUTANEOUS) FIBROMA 3/60 3/60 18/60 20/60 FIBROMA OR FIBROSARCOMA 3/60 3/60 21/60 22/60	Neoplastic Lesions
No	TR-504	88-72-2	o-Nitrotoluene	Rats	F344/N	Male	Dosed-Feed	Skin	Clear Evidence	Clear Evidence	(SUBCUTANEOUS) LIPOMA 0/60 4/60 13/60 13/60 10/60 12/60 FIBROMA 5/60 46/60 52/60 59/60 45/60 52/60 FIBROSARCOMA 0/60 7/60 17/60 20/60 8/60 12/60 COMBINED 5/60 47/60 55/60 59/60 47/60 53/60	Neoplastic Lesions
No	TR-099	136-40-3	Phenazopyridine hydrochloride	Mice	B6C3F1	Male	Dosed-Feed	Unspecified	Negative		Not applicable	Not applicable
Yes	TR-099	136-40-3	Phenazopyridine hydrochloride	Rats	F344/N	Female	Dosed-Feed	Intestines (Large)	Positive	Positive	(ADENOCARCINOMA)	Neoplastic Lesions
Yes	TR-099	136-40-3	Phenazopyridine hydrochloride	Rats	F344/N	Male	Dosed-Feed	Intestines (Large)	Positive	Positive	(ADENOCARCINOMA)	Neoplastic Lesions
No	TR-099	136-40-3	Phenazopyridine hydrochloride	Mice	B6C3F1	Female	Dosed-Feed	Liver	Positive	Positive	(ADENOMA, CARCINOMA)	Neoplastic Lesions
No	TR-587	79-94-7	Tetrabromobisphenol A	Mice	B6C3F1/N	Male	Gavage	All Organs	Some Evidence	Equivocal Evidence	(Hemangiosarcoma) 1/50 5/50 8/50	May Have Been Related
Yes	TR-587	79-94-7	Tetrabromobisphenol A	Mice	B6C3F1/N	Male	Gavage	Intestines (Large)	Some Evidence	Equivocal Evidence	(cecum or colon) adenoma or carcinoma 0/50 0/50 3/50	May Have Been Related
No	TR-587	79-94-7	Tetrabromobisphenol A	Mice	B6C3F1/N	Male	Gavage	Liver	Some Evidence	Some Evidence	hepatoblastoma 2/50 11/50 8/50	Neoplastic Lesions
No	TR-587	79-94-7	Tetrabromobisphenol A	Rats	Wistar Han	Male	Gavage	Testis	Equivocal Evidence	Equivocal Evidence	interstitial cell, adenoma 0/50 0/50 1/50 3/50	May Have Been Related
No	TR-587	79-94-7	Tetrabromobisphenol A	Rats	Wistar Han	Female	Gavage	Uterus	Clear Evidence	Clear Evidence	adenoma (original transverse review) 0/50 0/50 3/50 4/50 adenocarcinoma (original transverse review) 3/50 3/50 8/50 9/50 )original transverse and residual longitudinal reviews, combined) 4/50 10/50 15/50 16/50 malignant mixed Müllerian tumor (original transverse review) 0/50 4/50 0/50 2/50 adenoma, adenocarcinoma, or malignant mixed Müllerian tumor (original transverse review) 3/50 7/50 11/50 13/50 )original transverse and residual longitudinal reviews, combined) 6/50 11/50 16/50 19/50	Neoplastic Lesions
No	TR-350	75-25-2	Tribromomethane	Mice	B6C3F1	Female	Gavage	Unspecified	No Evidence		Not applicable	Not applicable
No	TR-350	75-25-2	Tribromomethane	Mice	B6C3F1	Male	Gavage	Unspecified	No Evidence		Not applicable	Not applicable
Yes	TR-350	75-25-2	Tribromomethane	Rats	F344/N	Female	Gavage	Intestines (Large)	Clear Evidence	Clear Evidence	ADENOMATOUS POLYP 0/48 1/50 6/49 OR ADENOCARCINOMA 0/48 0/50 2/49 COMBINED 0/48 1/50 8/49	Neoplastic Lesions
Yes	TR-350	75-25-2	Tribromomethane	Rats	F344/N	Male	Gavage	Intestines (Large)	Some Evidence	Some Evidence	ADENOMATOUS POLYP 0/50 0/50 2/50 OR ADENOCARCINOMA 0/50 0/50 1/50 COMBINED 0/50 0/50 3/50	Neoplastic Lesions
Yes	TR-549	5589-96-8	Water disinfection byproducts (Bromochloroacetic acid)	Rats	F344/N	Female	Dosed-Water	Intestines (Large)	Clear Evidence	Clear Evidence	Adenoma 0/50 0/50 3/50 7/50	Neoplastic Lesions
Yes	TR-549	5589-96-8	Water disinfection byproducts (Bromochloroacetic acid)	Rats	F344/N	Male	Dosed-Water	Intestines (Large)	Clear Evidence	Clear Evidence	Adenoma 0/50 2/50 0/50 4/50	Neoplastic Lesions
No	TR-549	5589-96-8	Water disinfection byproducts (Bromochloroacetic acid)	Rats	F344/N	Female	Dosed-Water	Liver	Clear Evidence	Equivocal Evidence	Adenoma 0/50 0/50 0/50 3/50	May Have Been Related
No	TR-549	5589-96-8	Water disinfection byproducts (Bromochloroacetic acid)	Rats	F344/N	Male	Dosed-Water	Liver	Clear Evidence	Equivocal Evidence	Adenoma 2/50 0/50 3/50 4/50	May Have Been Related
No	TR-549	5589-96-8	Water disinfection byproducts (Bromochloroacetic acid)	Mice	B6C3F1/N	Female	Dosed-Water	Liver	Clear Evidence	Clear Evidence	Adenoma 27/50 48/50 44/50 46/50 carcinoma 14/50 23/50 26/50 20/50 adenoma or carcinoma 31/50 49/50 46/50 46/50	Neoplastic Lesions
No	TR-549	5589-96-8	Water disinfection byproducts (Bromochloroacetic acid)	Mice	B6C3F1/N	Male	Dosed-Water	Liver	Clear Evidence	Clear Evidence	Adenoma 27/50 40/50 40/50 31/50 carcinoma 19/50 25/50 36/50 45/50 adenoma or carcinoma 34/50 44/50 49/50 49/50 hepatoblastoma 4/50 11/50 28/50 34/50	Neoplastic Lesions
No	TR-549	5589-96-8	Water disinfection byproducts (Bromochloroacetic acid)	Rats	F344/N	Female	Dosed-Water	Mammary Gland	Clear Evidence	Clear Evidence	Fibroadenoma, multiple 22/50 24/50 43/50 38/50	Neoplastic Lesions
No	TR-549	5589-96-8	Water disinfection byproducts (Bromochloroacetic acid)	Rats	F344/N	Male	Dosed-Water	Mesothelium (Abdominal Cavity/Tunica Vaginalis)	Clear Evidence	Clear Evidence	Malignant Mesothelioma 1/50 5/50 10/50 6/50	Neoplastic Lesions
No	TR-549	5589-96-8	Water disinfection byproducts (Bromochloroacetic acid)	Rats	F344/N	Male	Dosed-Water	Pancreas Islet Cell	Clear Evidence	Equivocal Evidence	Adenoma 3/50 4/50 9/50 3/50	May Have Been Related