Search Results

One moment please while the data are loaded...

The DNTP Technical Report (TR) Level of Evidence Criteria are available here: https://ntp.niehs.nih.gov/go/baresults. In the table below this information is further delineated into three fields:

Level of Evidence: The overall category of evidence of carcinogenic activity for the TR, Species, Strain and Sex
Organ Site Call: The level of evidence supported by the specific organ site for the TR, Species, Strain and Sex. When the Organ Site Call directly supports the TR Level Of Evidence the Finding Type flag is set to “Neoplastic Lesion”. Some Organ Site Calls could support a separate call of Equivocal Evidence; this is noted in Finding Type by the flag “May Have Been Related”
Finding Type: Further identification of the Organ Site Call. Where this says “Neoplastic Lesion” the Organ Site Call supports the TR Level of Evidence and the Organ Site Call is the same as that of the TR. Where Finding Type says “May Have Been Related” the TR Level of Evidence for other responses led to an overall call of Clear or Some Evidence but the specified organ supports a call of Equivocal Evidence.

Displays results that match exactly with the given criteria.
Exact Match	Publication No.	CASRN	Test Article Name	Species	Strain	Sex	Route	Organ	Level of Evidence	Organ Site Call	Tumor Type/Incidence	Finding Type
Yes	TR-581	7440-48-4	Cobalt	Rats	F344/NTac	Male	Inhalation	Kidney	Clear Evidence	Equivocal Evidence	adenoma or carcinoma (standard evaluation) 0/50 1/50 0/50 4/50 (standard and extended evaluations combined) 3/50 1/50 1/50 7/50	May Have Been Related
Yes	TR-561	119-64-2	Tetralin	Rats	F344/N	Male	Inhalation	Kidney	Some Evidence	Some Evidence	Cortical renal tubule adenoma (standard evaluation) 0/50 1/50 1/50 2/50 standard and extended combined 0/50 3/50 2/50 6/50	Neoplastic Lesions
Yes	TR-582	75-35-4	Vinylidene Chloride	Mice	B6C3F1/N	Male	Inhalation	Kidney	Clear Evidence	Clear Evidence	renal tubule adenoma 0/50 5/50 19/50 10/50 renal tubule carcinoma 0/50 7/50 31/50 18/50 renal tubule adenoma or carcinoma 0/50 11/50 37/50 27/50	Neoplastic Lesions
Yes	TR-582	75-35-4	Vinylidene Chloride	Rats	F344/N	Male	Inhalation	Kidney	Clear Evidence	Clear Evidence	renal tubule carcinoma 0/50 2/50 1/49 1/50	Neoplastic Lesions

Displays all results in TRs which have data that match the given criteria.
Exact Match	Publication No.	CASRN	Test Article Name	Species	Strain	Sex	Route	Organ	Level of Evidence	Organ Site Call	Tumor Type/Incidence	Finding Type
No	TR-581	7440-48-4	Cobalt	Rats	F344/NTac	Female	Inhalation	Adrenal Gland Medulla	Clear Evidence	Clear Evidence	benign pheochromocytoma 6/50 12/50 22/50 36/50 malignant pheochromocytoma 0/50 2/50 3/50 11/50 benign or malignant pheochromocytoma 6/50 13/50 23/50 40/50	Neoplastic Lesions
No	TR-581	7440-48-4	Cobalt	Rats	F344/NTac	Male	Inhalation	Adrenal Gland Medulla	Clear Evidence	Clear Evidence	benign pheochromocytoma 15/50 23/50 37/50 34/50 malignant pheochromocytoma 2/50 2/50 9/50 16/50 benign or malignant pheochromocytoma 17/50 23/50 38/50 41/50	Neoplastic Lesions
No	TR-581	7440-48-4	Cobalt	Rats	F344/NTac	Female	Inhalation	All Organs	Clear Evidence	Clear Evidence	Mononuclear Cell Leukemia 16/50 29/50 28/50 27/50	Neoplastic Lesions
Yes	TR-581	7440-48-4	Cobalt	Rats	F344/NTac	Male	Inhalation	Kidney	Clear Evidence	Equivocal Evidence	adenoma or carcinoma (standard evaluation) 0/50 1/50 0/50 4/50 (standard and extended evaluations combined) 3/50 1/50 1/50 7/50	May Have Been Related
No	TR-581	7440-48-4	Cobalt	Mice	B6C3F1/N	Female	Inhalation	Lung	Clear Evidence	Equivocal Evidence	alveolar/bronchiolar adenoma 3/49 9/50 8/50 10/50 alveolar/bronchiolar carcinoma 5/49 25/50 38/50 43/50 alveolar/bronchiolar adenoma or carcinoma 8/49 30/50 41/50 45/50	May Have Been Related
No	TR-581	7440-48-4	Cobalt	Rats	F344/NTac	Male	Inhalation	Lung	Clear Evidence	Equivocal Evidence	cystic keratinizing epithelioma 0/50 1/50 0/50 1/50	May Have Been Related
No	TR-581	7440-48-4	Cobalt	Mice	B6C3F1/N	Male	Inhalation	Lung	Clear Evidence	Clear Evidence	alveolar/bronchiolar adenoma 7/50 11/49 15/50 3/50 alveolar/bronchiolar carcinoma 11/50 38/49 42/50 46/50 alveolar/bronchiolar adenoma or carcinoma 16/50 41/49 43/50 47/50	Neoplastic Lesions
No	TR-581	7440-48-4	Cobalt	Rats	F344/NTac	Female	Inhalation	Lung	Clear Evidence	Clear Evidence	alveolar/bronchiolar adenoma 2/50 7/50 9/50 13/50 alveolar/bronchiolar carcinoma 0/50 9/50 17/50 30/50 alveolar/bronchiolar adenoma or carcinoma 2/50 15/50 20/50 38/50 cystic keratinizing epithelioma 0/50 4/50 1/50 2/50	Neoplastic Lesions
No	TR-581	7440-48-4	Cobalt	Rats	F344/NTac	Male	Inhalation	Lung	Clear Evidence	Clear Evidence	alveolar/bronchiolar adenoma 2/50 10/50 10/50 14/50 alveolar/bronchiolar carcinoma 0/50 16/50 34/50 36/50 alveolar/bronchiolar adenoma or carcinoma 2/50 25/50 39/50 44/50	Neoplastic Lesions
No	TR-581	7440-48-4	Cobalt	Rats	F344/NTac	Female	Inhalation	Pancreas Islet Cell	Clear Evidence	Equivocal Evidence	carcinoma 1/50 0/50 0/50 3/50	May Have Been Related
No	TR-581	7440-48-4	Cobalt	Rats	F344/NTac	Male	Inhalation	Pancreas Islet Cell	Clear Evidence	Clear Evidence	adenoma or carcinoma 2/50 2/50 10/48 9/49	Neoplastic Lesions
Yes	TR-561	119-64-2	Tetralin	Rats	F344/N	Male	Inhalation	Kidney	Some Evidence	Some Evidence	Cortical renal tubule adenoma (standard evaluation) 0/50 1/50 1/50 2/50 standard and extended combined 0/50 3/50 2/50 6/50	Neoplastic Lesions
No	TR-561	119-64-2	Tetralin	Rats	F344/N	Female	Inhalation	Liver	Some Evidence	Some Evidence	Adenoma 0/50 0/50 0/50 3/50 adenoma or carcinoma 0/50 0/50 1/50 4/50	Neoplastic Lesions
No	TR-561	119-64-2	Tetralin	Mice	B6C3F1/N	Female	Inhalation	Spleen	Equivocal Evidence	Equivocal Evidence	Hemangiosarcoma 1/50 0/50 1/50 4/50	May Have Been Related
No	TR-561	119-64-2	Tetralin	Rats	F344/N	Male	Inhalation	Testis	Some Evidence	Equivocal Evidence	Adenoma, interstitial cell 29/50 39/50 31/50 41/50	May Have Been Related
No	TR-561	119-64-2	Tetralin	Rats	F344/N	Female	Inhalation	Uterus	Some Evidence	Some Evidence	Stromal polyp 6/50 10/50 9/50 17/50	Neoplastic Lesions
No	TR-582	75-35-4	Vinylidene Chloride	Rats	F344/N	Female	Inhalation	All Organs	Some Evidence	Equivocal Evidence	malignant mesothelioma 0/50 1/50 1/50 0/50	May Have Been Related
No	TR-582	75-35-4	Vinylidene Chloride	Mice	B6C3F1/N	Female	Inhalation	All Organs	Clear Evidence	Clear Evidence	hemangioma or hemangiosarcoma 4/50 6/50 6/50 11/50	Neoplastic Lesions
No	TR-582	75-35-4	Vinylidene Chloride	Rats	F344/N	Male	Inhalation	All Organs	Clear Evidence	Clear Evidence	malignant mesothelioma 1/50 12/50 28/50 23/50	Neoplastic Lesions
No	TR-582	75-35-4	Vinylidene Chloride	Rats	F344/N	Female	Inhalation	All Organs	Some Evidence	Some Evidence	mononuclear cell leukemia 10/50 11/50 13/50 25/50	Neoplastic Lesions
No	TR-582	75-35-4	Vinylidene Chloride	Mice	B6C3F1/N	Female	Inhalation	Intestines (Small)	Clear Evidence	Equivocal Evidence	(Duodenum, Jejunum, or Ileum): carcinoma 1/50 1/50 1/50 3/50	May Have Been Related
Yes	TR-582	75-35-4	Vinylidene Chloride	Mice	B6C3F1/N	Male	Inhalation	Kidney	Clear Evidence	Clear Evidence	renal tubule adenoma 0/50 5/50 19/50 10/50 renal tubule carcinoma 0/50 7/50 31/50 18/50 renal tubule adenoma or carcinoma 0/50 11/50 37/50 27/50	Neoplastic Lesions
Yes	TR-582	75-35-4	Vinylidene Chloride	Rats	F344/N	Male	Inhalation	Kidney	Clear Evidence	Clear Evidence	renal tubule carcinoma 0/50 2/50 1/49 1/50	Neoplastic Lesions
No	TR-582	75-35-4	Vinylidene Chloride	Mice	B6C3F1/N	Male	Inhalation	Liver	Clear Evidence	Equivocal Evidence	hepatocholangiocarcionoma 1/50 2/50 2/50 3/50	May Have Been Related
No	TR-582	75-35-4	Vinylidene Chloride	Mice	B6C3F1/N	Female	Inhalation	Liver	Clear Evidence	Clear Evidence	hepatocellular adenoma 25/50 21/50 36/50 29/50 hepatocellular carcinoma 8/50 14/50 12/50 17/50 hepatocellular adenoma or carcinoma 28/50 30/50 37/50 38/50 hepatocholangiocarcinoma 0/50 1/50 1/50 2/50	Neoplastic Lesions
No	TR-582	75-35-4	Vinylidene Chloride	Mice	B6C3F1/N	Female	Inhalation	Lung	Clear Evidence	Equivocal Evidence	alveolar/bronchiolar carcinoma 1/50 2/50 7/50 5/49	May Have Been Related
No	TR-582	75-35-4	Vinylidene Chloride	Rats	F344/N	Male	Inhalation	Nasal Cavity	Clear Evidence	Clear Evidence	respiratory epithelium, adenoma 0/49 0/50 1/50 4/50	Neoplastic Lesions
No	TR-582	75-35-4	Vinylidene Chloride	Rats	F344/N	Female	Inhalation	Thyroid Gland C-Cell	Some Evidence	Some Evidence	adenoma 3/50 4/50 6/48 11/50; carcinoma 0/50 6/50 2/48 2/50 adenoma or carcinoma 3/50 10/50 8/48 13/50	Neoplastic Lesions